bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation Between Depression and Intimacy in Lung Cancer Patients and Theire Family Caregivers
Authors: Zhong Jiudi , Li Chuanzhen , Yuan Juan , Huang Xiaoxiao , Hong Yutong , Zhang Siwen 
Published: March 2022

Abstract
Objective: To explore the interdependence between depression and intimacy in lung cancer patients and their family caregivers for further developing a patient- and caregiver-centered dyadic intervention. Methods: A convenient sampling was adopted to select 182 dyads of lung cancer patients and their family caregivers; the depression subscale of the Hospital Anxiety and Depression Scale (HADS) and the Mutuality Scale (MS) were used to measure participants’ depression and intimacy respectively; and the correlation between depression and intimacy in patients and caregivers was analyzed by establishing the actor-partner interdependence model (APIM). Results: 34% of the patients and 19.2% of the caregivers were at risk of depression, with an intimacy score of 2.67±0.74 points and 2.6±0.86 points, respectively; Pearson correlation analysis showed that there was a positive correlation between the depression score (r=0.226, P<0.01) and intimacy score (r=0.344, P<0.01) in patients and caregivers; and the APIM result showed that caregivers’ depression had an actor effect on their own intimacy (b=-0.054, P=0.004) as well as a partner effect on patients’ intimacy (b=-0.041, P= 0.011). Conclusion: There is a close correlation between depression and intimacy in lung cancer patients and family caregivers. Therefore, dyadic interventions can help them to cope with cancer together.
The Structural Connectivity of The Human Angular Gyrus as Revealed by Microdissection and Diffusion Tractography
Authors: Petit Laurent , Ali Kariem Mahdy , Rheault François , Boré Arnaud , Corsini Francesco , De Benedictis Alessandro , Descoteaux Maxime , Sarubbo Silvio 
Published: March 2022

Abstract
The angular gyrus (AG) has been described in numerous studies to be consistently activated in various functional tasks. The angular gyrus is a critical connector epicenter linking multiple functional networks regarding its location in the posterior part of the inferior parietal cortex, namely at the junction between the parietal, temporal, and occipital lobes. It is thus crucial to identify the different pathways that anatomically connect this high-order association region to the rest of the brain. Our study revisits the three-dimensional architecture of the structural AG connectivity by combining state-of-the-art postmortem blunt microdissection with advanced in vivo diffusion tractography to propose a comprehensive description of the association, projection, and commissural fibers that connect the human angular gyrus. AG appears as a posterior "angular stone" of associative connections belonging to mid- and long-range dorsal and ventral fibers of the superior and inferior longitudinal systems, respectively, to short-range parietal, occipital and temporal fibers including U-shaped fibers the posterior transverse system. Thus, AG is at a pivotal dorso-ventral position reflecting its critical role in the different functional networks, particularly in language elaboration and spatial attention and awareness in left and right hemispheres, respectively. We also reveal striatal, thalamic, and brainstem connections and a typical inter-hemispheric homotopic callosal connectivity supporting the suggested AG role, in the integration of sensory input for modulating motor control and planning. The present description of AG's highly distributed wiring diagram may drastically improve intraoperative subcortical testing and post-operative neurologic outcomes related to surgery in and around the angular gyrus.
Effects of Cycloplegic Agents on Ocular Parameters in Children with Myopia and Hyperopia
Authors: Qu Guangzhi , Liu Xiaocui , Gao Lei , Ding Saisai , Wang Xuli 
Published: March 2022

Abstract
Background
To study the effect of cycloplegia on ocular parameters in children with myopia and hyperopia.
Methods
Forty two myopia and forty four hyperopia eyes in children between 5 and 10 years of age were included. Measurements were taken before and after cycloplegia using 1% atropine sulfate ointment. The ocular parameters included central corneal thickness (CCT), corneal curvature (CC), anterior chamber depth (ACD), pupil diameter (PD), axial length (AL) and central retinal thickness (CRT).
Results
There was no significant difference in CCT, CC and CRT between the two groups without cycloplegia, but the ACD of myopia (3.64 ± 0.28mm) group was significantly higher than that of hyperopia (3.40 ± 0.24mm, t=-4.522, P < .0001). The average PD of myopia (4.85 ± 0.87mm) group was significantly smaller than that of hyperopia group (5.47 ± 1.15mm, t = 2.903, P < .0046). The average AL of myopia (24.25 ± 0.77mm) was significantly higher than that of hyperopia (21.73 ± 1.24mm, t = 12.084, P < .0001). However, it was found that the average PD of myopia (7.68 ± 0.51mm) was significantly larger than that of hyperopia (7.41 ± 0.57mm, t = 2.364, P = .0202) under cycloplegia. As for the changes of refractive factors before and after cycloplegia, Deepened ACD and enlarged PD was noted in both group after cycloplegia.
Conclusions
Cycloplegia not only affects ACD and PD, but also leads to the reversal of PD difference between the two groups. The cycloplegia effects enabled us to study changes in all known ocular parameters in a short period of time.
Rehabilitative Strategies After Filtering Procedure in Glaucoma
Authors: Vingolo Enzo , Casillo Lorenzo , Mecarelli Giulia , Limoli Paolo Giuseppe 
Published: March 2022

Abstract
Background: Glaucoma is one of the leading causes of non-reversible blindness worldwide, and almost 6 million people are estimated to be impaired visually in advanced stage of glaucoma. Recently, several studies on glaucoma has been focused towards new therapeutic approaches based on mechanisms independent from IOP control. Effects of new therapeutic agents, visual psychophysical training, or complementary medications targeting optic pathways today seem to be a relevant and effervescent field of research. The goal of the study is to evaluate in glaucoma patients if a rehabilitative strategy with a biofeedback training with microperimetry may be useful after surgery in recovery visual performance even when visual field defects are present in IOP is well controlled environment. Materials and Methods: Were enrolled 24 patients (28 eyes) with Primary Open Angle Glaucoma (POAG) (mean 63 range: 49–75 years) from our Glaucoma Center after filtering surgery. All patients after one months from surgical intervention underwent to a complete ophthalmologic examination: IOP measurement, gonioscopy, visual field and SD-OCT at baseline of RNFL thickness. In some cases, were included in the study both eyes because in POAG frequently clinical conditions are different in each eye, and secondarily new fixation target retinal location (TRL) was chosen based on single eye retinal sensitivity.Results: Best corrected visual acuity was significantly increased after the training from 0,61 to 0,479 (p=0,00058) with no change in refractive error. After the biofeedback patients presented increased value in Mean retinal sensitivity from 14,91 to 15,96 (p=0,0078).Fixation stabilitywas improved either according to Fuji classification (increased from 75,1% to 81.3% p=0,0073) or BCEA value, reduced from 8,7 to 6,0 square degrees (p=0,013) we noted a marked increase in this parameter with better performances and satisfaction by the patient. RFNL thickness: no change was noted (p=0,505) in this value as an indicator of disease’s stability. Conclusions: Our data indicate that MP-3 Biofeedback may be a good strategy to reduce the impairment of the Glaucoma Patient.
Cinnamomeoventrolide – Double-bond Regioisomerism in Frog Semiochemcials
Authors: Schulz Stefan , KUHN JOHANNA 
Published: March 2022

Abstract
Frogs of the families Mantellinae and Hyperoliidae possess male specific femoral or gular glands that are used during courtship. These glands release volatile compounds, e. g. the macrocyclic lactone gephyromantolide A (2,6,10-trimethyl-6-undecen-11-olide) in the case of Gephyromantis boulengeri (Mantellinae). During the analysis of the volatiles of Hyperolius cinnamomeoventris (Hyperoliidae) we detected a compound A showing high similarity with the spectrum of gephyromantolide A. Nevertheless, the slight differences led to the proposal of a regioisomer as a structure for A, 2,6,10-trimethyl-5-undecen-11-olide that we called cinnamomeoventrolide. To proof our proposal, a versatile synthesis was developed that allowed access to all four stereoisomers from a single chiral starting material, the so-called (S)-Roche ester, using ring-closing metathesis as a key step. With these stereoisomers the absolute configuration of the natural product was established to have the (2R,10S)-configuration by GC on a chiral phase. The configuration of natural gephyromantolide A is the opposite. Both frogs seem to use a similar biosynthetic pathway to the target compounds, differing in the stereochemistry of the reduction step, and requiring an additional isomerization in case of G. boulengeri. The unique regioisomer differentiation of double bonds has so far only been reported from insects. The compounds are likely to play a role in species-recognition of the frogs.
Clinical and pathogenetic relationship between IL-1β and IL-8 in melanoma
Authors: Malkova Anna , Orlova Rashida , Zhukova Natalia , Kaledina Ekaterina , Demchenkova Alexandra , Naymushina Polina , Sharoyko Vladimir 
Published: March 2022

Abstract
Immune checkpoint inhibitors (ICI) are mostly used for melanoma treatment, however, the efficacy is achieved not for every patient. The cause of therapy failure can be explained by local immune suppression, which might be induced by different cytokines, including IL-1β. IL-1β is difficult to detect in peripheral blood, meanwhile, the high concentrations of IL-8 are frequently reported. IL-8 production is known to be induced by IL-1β in many cell types, however, there is no data on melanoma cells. This study aims to determine the relationship between IL-1β and IL-8 in patients with metastatic (mts) melanoma and assess the effect of IL-1β on IL-8 production by melanoma cells in vitro. The study involved 28 patients (pts) with mts melanoma taking ICI. The level of IL-1β and IL-8 in blood serum was determined using the ELISA method. In the experiments SK-MEL cells were incubated with/without IL-1β (1-1-2-4 ng/ml) for 9 days, every 2 days the cell media was collected. According to the study, with an IL-8 concentration of more than 42.31 pg/ml in patients with mts melanoma, the presence of IL-1β in the blood serum can be expected. At the same time, the level of IL-8 correlated with the level of IL-1β. The study also showed a concentration-dependent increase in the production of IL-1β and IL-8 by human melanoma cells with external exposure to IL-1β. The data obtained can allow us to assume, that high expression of IL-1β contributes to IL-8 production in tumor microenvironment (TME), which can be observed in peripheral blood and serve as a biomarker of high IL-1β expression in TME and local immune suppression. A high IL-8 level might be associated with a low ICI efficacy, but it`s needed to be studied in the following research.
Methods for evaluating external facilitation as a strategy to nationally implement a novel stigma-reduction training tool for healthcare providers ​
Authors: Wasmuth Sally , Belkiewitz Johnna , Bravata Dawn M. , Horsford Caitlin , Harris Alex , Smith Carlton , Austin Charles , Miech Edward J. 
Published: March 2022

Abstract
Background. Identity Development Evolution and Sharing (IDEAS) is a theatre-based intervention for reducing healthcare provider stigma. IDEAS films are created by: collecting narratives from people who have experienced discrimination and healthcare inequity; partnering with professional playwrights to create theatrical scripts that maintain the words of the narratives while arranging them into compelling storylines involving several interviews; and hiring professional actors to perform and record scenes. IDEAS implementation requires a moderator to establish a respectful learning environment, play the filmed performance, set ground rules for discussion, and moderate a discussion between healthcare providers who viewed the film and invited panelists who are members of the minoritized population being discussed. IDEAS’ impact on provider stigma is measured via pre/post Acceptance and Action Questionnaire – Stigma (AAQ-S) data collected from participating providers. The objectives of this manuscript are to: provide narrative review of how provider stigma may lead to healthcare inequity and health disparities; describe the conceptual frameworks underpinning the IDEAS intervention; and outline methods for IDEAS implementation and implementation evaluation. Methods. This manuscript describes a hybrid type 3 design study protocol that uses the Consolidated Framework for Implementation Research (CFIR) to evaluate external facilitation, used as an implementation strategy to expand the reach of IDEAS. CFIR is also used to assess the impact of characteristics of the intervention and implementation climate on implementation success. Implementation success is defined by intervention feasibility and acceptability as well as self-efficacy of internal facilitators. This manuscript details the protocol for collection and evaluation of implementation data alongside that of effectiveness data. The manuscript provides new information about the use of configurational analysis, which uses Boolean algebra to analyze pathways to implementation success considering each variable, within and across diverse clinical sites across the United States. Discussion. The significance of this protocol is that it outlines important information for future hybrid type 3 designs wishing to incorporate configurational analyses and/or studies using behavioral or atypical, complex, innovative interventions. The current lack of evidence supporting occupational justice-focused interventions and the strong evidence of stigma influencing health inequities underscore the necessity for the IDEAS intervention.
Perfect Association Between Spatial Swarm Segregation and The X-Chromosome Speciation Island in Hybridizing Anopheles Coluzzii and Anopheles Gambiae Populations
Authors: Niang Abdoulaye , Maïga Hamidou , Sawadogo Simon P. , Konaté Lassana , Faye Ousmane , Lee Yoosook , Dabiré Roch K. , Diabaté Abdoulaye , Tripet Frédéric 
Published: March 2022

Abstract
The sibling species An. coluzzii and An. gambiae s.s. are major malaria vectors thought to be undergoing sympatric speciation with gene flow. In the absence of intrinsic post-zygotic isolation between the two taxa, speciation is thought possible through the association of assortative mating and genomic regions protected from gene flow by recombination suppression. Such genomic islands of speciation have been described in pericentromeric regions of the X, 2L and 3L chromosomes. Spatial swarm segregation plays a major role in assortative mating between sympatric populations of the two species and, given their importance for speciation, genes responsible for such pre-mating reproductive barriers are expected to be protected within divergence islands. In this study 2063 male and 266 female An. coluzzii and An. gambiae s.s. individuals from natural swarms in Burkina Faso, West Africa were sampled. These were genotyped at 16 speciation island SNPs, and characterized as non-hybrid individuals, F1 hybrids or recombinant F1 + n backcrossed individuals. Their genotypes at each speciation island were associated with their participation in An. coluzzii and An. gambiae-like swarms. Despite extensive introgression between the two species, the X-island genotype of non-hybrid individuals (37.6%), F1 hybrids (0.1%) and F1 + n recombinants (62.3%) of either sex perfectly associated to each swarm type. Associations between swarm type and the 3L and 2L speciation islands were weakened or broken down by introgression. The functional demonstration of a close association between spatial segregation behaviour and the X speciation island lends further support to sympatric speciation models facilitated by pericentric recombination suppression in this important species complex.
Investigation on the magnetorheological shear thickening finishing with radial slotted magnetic pole for Sine surface
Authors: Sun Zhiguang , Fan Zenghua , Tian Yebing , Qian Cheng , Ma Zhen 
Published: March 2022

Abstract
Free-form surfaces have widespread applications in the fields of integrated circuit, and automobile sectors because of the typical geometric characteristics. Surface finishing of free-form surfaces is a critical process to fulfill target quality. In present study, a magnetorheological shear thickening finishing (MSTF) method is proposed for Sine surface finishing based on the designed finishing tool and the developed MSTF media. The MSTF utilizes a flexible finishing tool, integrating a slotted cylindrical permanent magnetic pole with radial magnetization, is fabricated to dominate rheological properties of finishing media to guarantee the finishing force. To obtain sufficiently large magnetic flux density and magnetic field gradients in the finishing zone, finite element analysis (FEA) is used to obtain the optimal dimensions and structure of the finishing tool. The principle of the method is illustrated and mathematical model of material removal is established. Finishing experiments were conducted on Sine surface fabricated by SUS304 based on the developed MSTF media and the established platform. The effects of finishing parameters on surface roughness are evaluated quantitatively. The results substantiate that the material was uniformly re-moved over the entire Sine surface and the developed method is capable for Si-ne finishing with a more than 87% improvement in surface roughness. The method in the paper shows signs of future success in finishing free-form surfaces in a wide range of industrial applications.
Ecosystem Service Value Based on Land Use/Cover Dynamics and Socio-Economic, Burullus Lake, Egypt
Authors: El-Hamid Hazem Abd , Toubar Mohamed M. , Zarzoura Fawzi , El-Alfy Muhammad A. 
Published: March 2022

Abstract
Burullus Lake is an ecological system that supplies a variety of ecosystem services (ES) to the community. The value of these services depends on change in land use and land cover LU/LC and socioeconomic factors as fish production. Supervised classification was applied showing four classes; water, vegetation, fishfarm and services lands. Markov and CA-Markov were applied for LU/LC transition and prediction. Results reveal an increase in water bodies due to recent development in Burullus Lake. Removal the floating plants reflects the decrease in vegetation. Area of fishfarm was increased from 2009 to 2013 that increase the value of ecosystem services in the study area in this period. These changes in LU/LC had a positive impact on ESV due to the conversion among different classes. ESV varied significantly in Burullus Lake. Increased value of ecosystem provides higher opportunities for recreation and ecotourism. Fish production of Lake Burullus has increased from 2009 to 2018 with an increase of 18,000 ton by about 34%, and this increase in may be the result of adding additional areas to Lake Burullus during this period as a result of purification operations as a main factor. Also, the lowest parts of exploitation were observed at the central parts directed to the fish farms areas. While the most exploited areas are towards the eastern parts to the area of El-Boughaz. It is indicated more that areas of jetties sites and population centers are more exploited to the lakes shores. The present study suggests that governments should take awareness of ESV through studying some ecological conditions.
DSTS: A hybrid optimal and deep reinforcement learning for dynamic scalable task scheduling on container cloud environment
Authors: Saravanan M , Vignesh R 
Published: March 2022

Abstract
Containers have grown into the most dependable and lightweight virtualization platform for delivering cloud services, offering flexible sorting, portability, and scalability. In cloud container services, planner components play a critical role. This enhances cloud resource workloads and diversity performance while lowering costs. We present a hybrid optimum and deep reinforcement learning approach for dynamic scalable task scheduling (DSTS) in a container cloud environment in this research. To expand containers virtual resources, we first offer a modified multi-swarm coyote optimization (MMCO) method, which improves customer service level agreements. Then, to assure priority-based scheduling, we create a modified pigeon-inspired optimization (MPIO) method for task clustering and a rapid adaptive feedback recurrent neural network (FARNN) for pre-virtual CPU allocation. Meanwhile, the task load monitoring system is built on a deep convolutional neural network (DCNN), which allows for dynamic priority-based scheduling. Finally, the presentation of the planned DSTS methodology will be estimated utilizing various test vectors, and the results will be associated to present state-of-the-art techniques.
X-dimensional Mass Spectrometry Imaging Discovers Spatially Resolved Metabolic Response
Authors: Song Xiaowei , Zang Qingce , Zhang Jin , Gao Shanshan , Zheng Kailu , Li Yan , Abliz Zeper , He Jiuming 
Published: March 2022

Abstract
This study developed an open-source method, x-dimensional mass spectrometry imaging (MSI(x)), to reveal the spatially-resolved high-order metabolomics information associated with disease progression or drug action. This high order bioinformation includes metabolism pathway, species, biofunction, or biotransformation, which involves multiplex metabolites and cannot be presented by a single ion image. The MSI(x) enables the evaluation of the physiological status, the discovery of therapeutic or adverse effects, the investigation of regional heterogeneous response to drug treatment, possible molecular mechanism, and even drug potential target. MSI(x) was demonstrated to be a promising molecular imaging tool not only for efficacy and safety evaluation but also for the molecular mechanism investigation at the early stage of drug research and development.
Evidence of Self-Organised Criticality in Time Series by the Horizontal Visibility Graph Approach
Authors: Kaki Bardia , Farhang Nastaran , Safari Hossein 
Published: March 2022

Abstract
Determination of self-organised criticality (SOC) is crucial in evaluating the dynamical behavior of a time series. Here, we apply the complex network approach to assess the SOC characteristics in synthesis and real-world data sets. To this purpose, we employ the horizontal visibility graph (HVG) method and construct the relevant networks for the observational and numerical avalanching events (e.g., earthquakes and sand-pile models), financial markets, and the solar nano-flare emission model, which showed to have long-temporal correlations via re-scaled range analysis. We compute the degree distribution, maximum eigenvalue, and average clustering coefficient of each HVG and compare them with the values obtained for random and chaotic processes. The result manifests a perceptible deviation between these parameters in random and SOC time series. We conclude that the mentioned HVG’s features can distinguish between SOC and random systems.