bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of Vertigo, Imbalance, and Other Minor Symptoms in Hyperacute Treatment of Posterior Circulation Stroke
Authors: Kim Min , Park So Young , Lee Sung Eun , Lee Jin Soo , Hong Ji Man , Lee Seong-Joon 
Published: May 2022

BackgroundThis study aimed to determine the clinical significance of acute vestibular syndrome (AVS)/acute imbalance syndrome (AIS) in posterior circulation stroke (PCS) and how it should be addressed in the thrombolysis code.MethodsOur institution has recently changed its thrombolysis code from one that is generous to AVS/AIS to one that is exclusive. The subjects in this study were patients with PCS who presented before this transition (May 2016 to April 2018, period 1) and those who presented after (January 2019 to December 2020, period 2) with an onset-to-door time of 4.5 h. Hyperacute stroke treatment was compared between the two periods. The clinical significance of AVS/AIS was evaluated by dichotomizing the patients' clinical severity to minor or major deficits, then evaluating the significance of AVS/AIS in each group. Presenting symptoms of decreased mental alertness, hemiparesis, aphasia (anarthria), or hemianopsia were considered major PCS symptoms, and patients who did not present with these symptoms were considered minor PCS.ResultsIn total, 114 patients presented in period 1 and 114 in period 2. Although the code activation rate was significantly lower in period 2 (72.8% vs. 59.7%), p = 0.04, there were no between-group differences in functional outcomes (mRS score at 3 months; 1 [0–3] vs. 0 [0–3], p = 0.18). In 77 patients with PCS and AVS/AIS, the difference in code activation rate was not significant according to changes in thrombolysis code. In minor PCS, AVS/AIS was associated with lower NIHSS scores, lower early neurological deterioration rates, and favorable outcomes. In major PCS, while AVS/AIS was not associated with outcomes, the majority of cases were prodromal AVS/AIS which simple vertigo and imbalance symptoms were followed by a major PCS symptom.ConclusionsThis study failed to show differences in outcome in patients with PCS according to how AVS/AIS is addressed in the stroke thrombolysis code. In patients with minor PCS, AVS/AIS was associated with a benign clinical course. Prompt identification of prodromal AVS/AIS is essential.
Cancer-Secreted Exosomal MiR-620 Inhibits ESCC Aerobic Glycolysis via FOXM1/HER2 Pathway and Promotes Metastasis
Authors: Zhu Yanbo , Li Fang , Wan Yilong , Liang Hansi , Li Si , Peng Bo , Shao Liqun , Xu Yunyun , Jiang Dong 
Published: May 2022

BackgroundEsophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide. MicroRNAs (MiRNAs) have been reported to regulate cell functions through exosomes. Through the Gene Expression Omnibus (GEO) database, miR-620 was selected as a serum miRNA highly expressed in ESCC, but its detailed role in ESCC has not been explored. Tumor-secreted miRNAs have been reported to promote cancer metastasis through reprogramming the aerobic glycolysis of lung fibroblasts. Therefore, we intended to verify whether exosomal miR-620 secreted in ESCC cells may regulate the aerobic glycolysis of lung fibroblasts.MethodsThe effect of miR-620 on the aerobic glycolysis of ESCC cells was firstly verified through bioinformatics prediction and mechanism assays. Exosomes secreted from ESCC cells was detected, and the influence of exosomal miR-620 in regulating the aerobic glycolysis of lung fibroblasts was then verified both in vitro and in vivo.ResultsMiR-620 inhibited ESCC malignancy and suppressed the aerobic glycolysis of ESCC cells via targeting Forkhead box M1 (FOXM1) and human epidermal growth factor receptor 2 (HER2). Moreover, exosomal miR-620 was highly secreted in ESCC and could regulate HFL1 aerobic glycolysis via FOXM1/HER2 signaling. Furthermore, exosomal miR-620 could promote ESCC metastasis by reprogramming the aerobic glycolysis of lung fibroblasts (HFL1).ConclusionExosomal miR-620 secreted by ESCC cells inhibited the aerobic glycolysis via FOXM1/HER2 axis and promoted cancer metastasis.
Dynamics of Cardiac Autonomic Responses During Hemodialysis Measured by Heart Rate Variability and Skin Sympathetic Nerve Activity: The Impact of Interdialytic Weight Gain
Authors: Zhang Yike , Wang Jing , Xing Yantao , Cui Chang , Cheng Hongyi , Chen Zhenye , Chen Hongwu , Liu Chengyu , Wang Ningning , Chen Minglong 
Published: May 2022

Background: Autonomic nervous regulation plays a critical role in end-stage kidney disease (ESKD) patients with cardiovascular complications. However, studies on autonomic regulation in ESKD patients are limited to heart rate variability (HRV) analysis. Skin sympathetic nerve activity (SKNA), which noninvasively reflects the sympathetic nerve activity, has not been used in ESKD patients.Methods: Seventy-six patients on maintenance hemodialysis (MHD) treatment (a 4-h HD session, three times a week) were enrolled. Utilizing a noninvasive, single-lead, high-frequency recording system, we analyzed the dynamic change in HRV parameters and SKNA during HD. The different characteristics between the subgroups divided based on interdialytic weight gain (IDWG, &lt;3 kg or ≥3 kg) were also demonstrated.Results: After the HD, values for heart rate (75.1 ± 11.3 to 80.3 ± 12.3 bpm, p &lt; 0.001) and LF/HF (1.92 ± 1.67 to 2.18 ± 2.17, p = 0.013) were significantly higher than baseline. In subgroup analysis, average voltage of skin sympathetic nerve activity (aSKNA) in IDWG ≥3 kg group was lower than the IDWG &lt;3 kg group at the end of MHD (1.06 ± 0.30 vs 1.32 ± 0.61 μV, p = 0.046). Moreover, there was a linear correlation between mean heart rate (HR) and aSKNA in low IDWG patients (p &lt; 0.001), which was not found in high IDWG patients. At the 1-year follow-up, high IDWG patients had a higher incidence of cardiovascular hospitalization (p = 0.046).Conclusions: In MHD patients, a gradual activation of sympathetic nerve activity could be measured by HRV and aSKNA. A lower aSKNA at the end of HD and a loss of HR-aSKNA correlation in overhydrated patients were observed. Extensive volume control is promising to improve the autonomic nervous function and clinical outcomes in this population.
Improving the Effectiveness of Healthcare: Diagnosis-Centered Care Vs. Person-Centered Health Promotion, a Long Forgotten New Model
Authors: Martyushev-Poklad Andrey , Yankevich Dmitry , Petrova Marina 
Published: May 2022

Performance of healthcare can be measured as its ability to restore and preserve health with acceptable costs for the society. Under the current prevalence of chronic disease, medical care (the major content of healthcare) underperforms in all key indicators: clinical effectiveness, benefit/risk ratio of interventions, cost/benefit ratio, and general population health. In Russia key performance indicators (KPI) of healthcare do not allow effective decision-making; a similar situation is seen worldwide: most KPIs are either focused on the process (not results) of medical care, or depend on efforts out of control of healthcare decision-makers.The key root factors limiting clinical effectiveness and cost-effectiveness of healthcare are reactive diagnosis-centered organizational model of care and the underlying biomedical paradigm, generally inadequate in chronic diseases. They make healthcare intervene too late, use less effective prevention and treatment instruments, and be in a state of resource scarcity. In Russia there is also a lack of interdisciplinary and interagency cooperation essential for health preservation and promotion.Performance of healthcare system in overcoming the chronic disease epidemic can be improved through supplementing the current ‘reactive’ organizational model with preventive person-centered model based on the biopsychosocial paradigm. Enabling patients for early lifestyle-based interventions, the core P4 medicine approach, should prevail in managing chronic disease. Communication and information technologies should allow fast scaling up of the best person-centered practices.
The Effect of Virtual Human Rendering Style on User Perceptions of Visual Cues
Authors: Stuart Jacob , Aul Karen , Stephen Anita , Bumbach Michael D. , Lok Benjamin 
Published: May 2022

Introduction: Virtual humans have expanded the training opportunities available to healthcare learners. Particularly, virtual humans have allowed simulation to display visual cues that were not previously possible in other forms of healthcare training. However, the effect of virtual human fidelity on the perception of visual cues is unclear. Therefore, we explore the effect of virtual human rendering style on the perceptions of visual cues in a healthcare context.Methods: To explore the effect of rendering style on visual cues, we created a virtual human interface that allows users to interact with virtual humans that feature different rendering styles. We performed a mixed design user study that had undergraduate healthcare students (n = 107) interact with a virtual patient. The interaction featured a patient experiencing an allergic reaction and required trainees to identify visual cues (patient symptoms). The rendering styles explored include a 3D modeled virtual human and an AI generated photorealistic virtual human. Visual cues were applied using a Snapchat Lens.Results: When users are given a frame of reference (users could directly compare symptoms on both rendering styles), they rated the realism and severity of the photorealistic virtual human’s symptoms significantly higher than the realism of the 3D virtual human’s symptoms. However, we were unable to find significant differences in symptom realism and severity ratings when users were not given a frame of reference (users only interacted with one style of virtual humans). Additionally, we were unable to find significant differences in user interpersonal communication behaviors between the 3D and photorealistic rendering styles.Conclusion: Our findings suggest 1) higher fidelity rendering styles may be preferred if the learning objectives of a simulation require observing subtle visual cues on virtual humans and 2) the realism of virtual human rendering style does not necessarily affect participants’ interpersonal communication behaviors (time spent, questions asked).
Preliminary Outcomes of Different Tactics of Ureteral Stent Placement in Patients with Ureteral Stricture Undergoing Balloon Dilatation: Experience from a Large-Scale Center
Authors: Hu Xiao , Feng Dechao , Wei Xin 
Published: May 2022

PurposeOur aim is to demonstrate the optimal number of ureteral stent placements in patients with a ureteral stricture (US) after balloon dilatation (BD).MethodsA retrospective analysis of 213 patients who underwent BD from 2011 to 2019 was conducted. All statistical analyses were completed by software SPSS 25.0.ResultsOf the patients enrolled, 119 were males and 94 were females. The average age was 44.71 years. One month after stent removal, the overall success rate of ureteral stent placement was 76.99%, and the success rates of single, double, and triple stent groups were 81.7%, 70.3%, and 79.3%, respectively. Six months after stent removal, the overall success rate was 61.9%, and the success rates of the three groups were 61.7%, 52.7%, and 74.1%, respectively. Twelve months after stent removal, the overall success rate was 55.9%, and the success rates of the three groups were 51.9%, 48.6%, and 70.7%, respectively. During indwelling of the stents, the proportions of severe bladder irritation symptoms in the three groups were 13.6%, 16.2%, and 20.7%, respectively. Multivariate analysis indicated the length of US and the time and number of ureteral stent placements were independent risk factors of the treatment effect at 6 months and 12 months after stent removal. Patients in the triple stent group had a better prognosis when compared to those in the single or double stent group.ConclusionThe long-term effect of three stents was better than that of single and double stents, but the success rate of treatment reduced gradually over time.
Efficacy of Bevacizumab Combined with Pemetrexed in the Treatment of Recurrent and Metastatic Cervical Cancer
Authors: He Ying , Wang Jing , Xie Shuangshuang , Xue Qianlong 
Published: May 2022

BackgroundTo investigate the efficacy and safety of bevacizumab combined with pemetrexed in the treatment of recurrent and metastatic cervical cancer.MethodsClinical data of 65 patients with recurrent and metastatic cervical cancer who were admitted to our hospital were collected for retrospective analysis. All patients were administered with bevacizumab combined with pemetrexed for 4–6 cycles (21 days as 1 cycle). The short-term clinical efficacy and adverse reactions were compared between the two groups. In addition, the survival status of patients was followed up and recorded.ResultsAt least 4 cycles of chemotherapy were given to the 65 patients. There were 0 cases of complete response (CR), 14 cases of partial response (PR), 36 cases of stable disease (SD) and 15 cases of progressive disease (PD). The objective response rate (ORR) and the disease control rate (DCR) were 21.5% (14/65) and 76.9% (50/65), respectively. DCR was superior in patients with squamous cell carcinoma to that in those with adenocarcinoma (p = 0.039), but no statistically significant difference was found in ORR. Patients with extra-pelvic metastatic lesions had a better efficacy than those with intra-pelvic metastatic lesions, but the difference was not statistically significant (p &gt; 0.05). The post-treatment adverse reactions mainly involved fatigue, nausea and vomiting, bleeding, leukopenia, anemia, thrombocytopenia, transaminase elevation, hypertension, proteinuria and neurotoxicity, most of which were grade I–II that ameliorated after symptomatic therapy. Grade III adverse reactions mainly included pain in 5 cases (7.7%), leukopenia in 17 cases (26.2%), anemia in 22 cases (33.8%), thrombocytopenia in 6 cases (9.2%), hypertension in 5 cases (7.7%) and neurotoxicity in 7 cases (10.8%). The follow-up results manifested that median overall survival (OS) and median progression-free survival (PFS) were 10.6 months and 6.6 months, respectively.ConclusionBevacizumab combined with pemetrexed exhibits certain efficacy in the treatment of recurrent and metastatic cervical cancer, with tolerable adverse reactions. Therefore, this therapeutic option deserves clinical popularization and application.
Evaluation of Plasma/Serum Adiponectin (an Anti-Inflammatory Factor) Levels in Adult Patients with Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis
Authors: Najafi Amir , Mohammadi Iman , Sadeghi Masoud , Brühl Annette Beatrix , Sadeghi-Bahmani Dena , Brand Serge 
Published: May 2022

Background and objective: A variety of diseases, including obesity, type ‖ diabetes, and cardiovascular diseases are associated with obstructive sleep apnea syndrome (OSAS), and decreased adiponectin levels have been shown to be associated with an increased risk of these diseases. However, the association of blood levels of adiponectin in OSAS patients is a challenging and unknown issue with conflicting results. Therefore, we performed a systematic review and a meta-analysis to evaluate plasma/serum adiponectin levels in adult patients with OSAS. Materials and methods: A comprehensive search in four databases (PubMed/Medline, Web of Science, Scopus, and Cochrane Library) was performed in literature dated older than 12 March 2022, to retrieve the relevant articles. Effect sizes were calculated to show the standardized mean difference (SMD) along with a 95% confidence interval (CI) of plasma/serum of adiponectin between the OSAS patients and controls. The software RevMan 5.3, NCSS 21.0.2, CMA 2.0, trial sequential analysis (TSA) 0.9.5.10 beta, and GetData Graph Digitizer 2.26 were used for data synthesis in the meta-analysis. Results: A total of 28 articles including 36 studies were entered into the meta-analysis. The results showed that pooled SMD was −0.71 (95% CI: −0.92, 0.50; p < 0.00001; I2 = 79%) for plasma/serum levels of adiponectin in OSAS cases compared to the controls. The subgroup analyses showed that the geographical region and the Apnea-Hypopnea-Index (AHI) could be confounding factors in the pooled analysis of plasma/serum adiponectin levels. The sensitivity analysis showed the stability of the results. The radial and L’Abbé plots confirmed evidence of heterogeneity. Trial sequential analysis showed sufficient cases in the meta-analysis. Conclusions: With sufficient cases and stable results, the main finding of the meta-analysis identified significantly reduced plasma/serum levels of adiponectin in OSAS cases compared with the controls. This result suggests a potential role of adiponectin in the pathogenesis of OSAS.
Sejarah Pendidikan Islam Di Era Moderasi Di Muhammadiyah Rejang Lebong
Authors: Budiman Budiman - , Murniyanto Murniyanto , Wanto Deri 
Published: May 2022

<p><em>Kajian adalah Faktor Penyebab Perkembangan Pendidikan Muhammadiyah K.H. Ahmad Dahlan.Tujuannya adalah untuk mengetahui apa yang muncul dari ide tersebut. Muhammadiyah adalah lembaga Pendidikan modern dan pelopor lembaga lainnya. Jenis survei ini adalah survei kepustakaan yang menggunakan pendekatan deskriptif analitis. Perkembangan pendidikan Islam modern di Indonesia bermula dari dikotomi masyarakat adat yang terdidik dengan baik pada masa penjajahan Belanda dan berbagai pengaruh yang membentuk perkembangan sistem pendidikan Islam di Indonesia. Berawal dari semangat perubahan, meninggalkan kolonialisme Belanda, konsep pendidikan nasional (masyarakat adat, rakyat, nasionalis) mulai muncul, yang membantu pendidikan nasional dan mengobarkan nasionalisme. Filosofi pendidikan Muhammadiyah menitikberatkan pada perpaduan antara keyakinan dan kemajuan dalam berpikir. K. H. Ahmad Daran juga berhasil memadukan dua ilmu yang berbeda dari menjadi satu Akibatnya, Pendidikan Muhammadiyah adalah pelopor dan pelopor pendidikan Islam modern. Reformasi Pendidikan oleh K.H. Ahmad Dalan menciptakan Lembaga Pendidikan Muhammadiyah yang berintegritas dalam sistem dan prakti pendidikannya, menjadi lembaga pendidikan modern dan merintis lembaga pendidikan lainnya.</em></p>
اتجاهات مدرسي الفيزياء نحو التدريس عبر المنصات التعليمية وبرامج التواصل الاجتماعي
Authors: M . Wissam Khalaf Jassem Al-Gharawi  
Published: May 2022

يهدف البحث الى التعرف على اتجاهات مدرسي الفيزياء في محافظة القادسية نحو التدريس عبر المنصات التعليمية وبرامج التواصل الاجتماعي استخدم الباحث المنهج الوصفي لكونه ملائم لهذه الدراسة تكون مجتمع البحث من مدرسي الفيزياء في المديرية العامة لتربية القادسية البالغ عددهم 243 مدرسا اختار 110 مدرسا بصوره عشوائية كانت اداة البحث الاستبيان من 55 فقرة وفق اربع مجالات (المجال الاول خبرة مدرسي الفيزياء بالتعليم الالكتروني والمجال الثاني المحتوى الدراسي والمجال الثالث استجابات الطلبة والمجال الرابع طرائق التدريس) تم التاكد من صدق المقياس وثباته استخدم الباحث الحقيبة الاحصائية SPSS لتحليل النتائج وحساب الثبات بواسطة معادلة الفا كروباخ استنتج الباحث هنالك اتجاهات سلبية لمدرسي الفيزياء نحو التدريس الالكتروني عبر المنصات التعليمية لاعتقادهم ان التعليم التقليدي وجها لوجه مع الطالب افضل لاعتقادهم انه لا يدعم الجوانب الاجتماعية وأن التدريس الاعتيادي أكثر تأثيرا من التدريس الالكتروني عبر منصات التواصل لان يختصر الوقت والجهد ووصى الباحث بعدد من التوصيات والمقترحات.
التحكم الذاتي لدى طلبة جامعة القادسية ( دراسة مقارنة )
Authors: Shurooq Kadhin Jabbar  , Nagham Adil Najm  , Hala Yahi Abass  
Published: May 2022

يهدف البحث الى التعرف على مستوى التحكم الذاتي لدى طلبة جامعة القادسية (دراسة مقارنة) وللدراسات الصباحية للعام الدراسي (2020 – 2021 م) ، ولتحقيق اهداف البحث الحالي قامت الباحثات بتبني مقياس ( روجرز 1986 ) والذي تم تطبيقه على مجتمع البحث المتمثل في طلبة جامعة القادسية وقد تكونت العينة من (100) طالب وطالبة تم اختيارهم بطريقة عشوائية وقد هدف البحث الحالي التعرف على :

هل يوجد سمة التحكم الذاتي عند طلبة جامعة القادسية .
التعرف على الفروق ذات الدلالة الاحصائية لدى عينة البحث في سمة التحكم الذاتي على وفق متغير التخصص للكليات ( العلمية – الانسانية )

وقد استخدمت الباحثات الأدوات الإحصائية لتحقيق اهداف البحث وقد توصلت الى نتائج البحث والتي كانت أهمها :

وجود سمة التحكم الذاتي لدى عينة البحث .
وجود اثر ذو دلالة إحصائية لنوع التخصص (العلمي - الانساني) لدى عينة البحث ولصالح التخصص العلمي .

وفي ضوء تلك النتائج وضعت الباحثات عدداً من التوصيات والمقترحات .
التفكير المتشعب وعلاقته بتوليد المعلومات الرياضية عند الطلبة /المدرسين في قسم الرياضيات
Authors: Prof. Dr. Abdul Wahid Mahmood Mohamed Alkanaany  
Published: May 2022

هدف البحث الى معرفة مستوى التفكير المتشعب وعلاقته بتوليد المعلومات عند الطلبة المدرسين في قسم الرياضيات، ولتحقيق اهداف البحث وضعت ثلاث فرضيات صفرية وهي:

لا يوجد فرق ذو دلالة احصائية عند مستوى الدلالة (0,05) بين المتوسط الحسابي لدرجات الطلبة المدرسين والمتوسط الفرضي في اختبار التفكير المتشعب.
لا يوجد فرق ذو دلالة احصائية عند مستوى الدلالة (0,05) بين المتوسط الحسابي لدرجات الطلبة المدرسين والمتوسط الفرضي في اختبار توليد المعلومات الرياضية.
لا توجد علاقة ارتباطية ذو دلالة احصائية عند مستوى الدلالة (0,05) بين متوسط درجات الطلبة المدرسين في اختبار التفكير المتشعب ومتوسط درجاتهم في اختبار توليد المعلومات.

اختيرت عينة البحث من طلبة المرحلة الرابعة- قسم الرياضيات من العام الدراسي 2020-2021، بلغ عددها (57) طالب وطالبة وبصورة عشوائية، اعد الباحث اختبارين احدهما للتفكير المتشعب مكون من (12) سؤال (8) أسئلة من نوع الاسئلة الموضوعية (الاختبار من متعدد )، و (4) أسئلة مقالية، والثاني اختبار مهارات توليد المعلومات وتكون من (9) أسئلة مقالية، تم التحقق من الخصائص السايكومترية للاختبارين بعد عرضهما على مجموعة من المحكمين في مادة الرياضيات وطرائق تدريسها، طبق الاختبارين على عينة البحث، واظهرت النتائج باستخدام الاختبار التائي لعينة واحدة ضعف في مستوى امتلاك عينة البحث لمهارات التفكير المتشعب، كما أظهرت النتائج ان عينة البحث تمتلك مهارات توليد المعلومات، فضلا عن وجود علاقة ارتباطية موجبة بين مهارات التفكير المتشعب ومهارات توليد المعلومات، وقد أوصى الباحث بضرورة اقامة دورات تدريبية او ندوات لتعريف القائمين على تدريس الرياضيات بمهارات التفكير المتشعب و مهارات توليد المعلومات.
واقع استخدام تكنولوجيا التعليم وطرائق التدريس الحديثة من قبل التدريسين في كلية الامام الكاظم (ع)
Authors: Assist L. Ruqayya Ghaly Maarij  
Published: May 2022

هدفت هذه الدراسة الى معرفة واقع استخدام الهيئات التدريسية في كلية الامام الكاظم (ع)لتكنولوجيا التعليم والبرامج الحديثة والكشف عن الفروق في استخدام وسائل الاتصال وتكنولوجيا التعليم تبعا لمتغير النوع الاجتماعي وتعزيز الكفايات المهنية ومواكبة التطورات السريعة لتكنولوجيا التعليم وكيفية استخدامها في العملية التعليمية في كلية الامام الكاظم (ع) ومدى توافر المعايير والاساليب وطرق التدريس الحديثة والاتجاهات التي يقوم عليها مجال تكنولوجيا التعليم في كلية الامام الكاظم والتعرف على اهم الصعوبات التي واجهت التدريسين باستخدام تكنولوجيا التعليم وطرق التدريس الحديثة لذلك اتبعت الباحثة المنهج الوصفي واختارت الباحثة عينة التدريسين في كلية الامام الكاظم (ع) البالغ عددهم (73)، 55 من الذكور و 18 من الاناث واستخدمت استبانة وذلك من خلال الرجوع الى الدراسات السابقة والاطار النظري، وتكونت الاستبانة من 26 فقرة في مجالين ( استخدام تكنلوجيا التعليم ، استخدام طرائق التدريس الحديثة ) وبتحليل البيانات الاحصائية (SPSS) من خلال استخدام النسبة المئوية والمتوسط الحسابي و t-test لعينة واحدة و t-testلعينتين مستقلتين والفاكرونباخ لقياس الصدق والثبات تم التوصل الى ان اغلب التدريسين يستخدمون تكنولوجيا المعلومات و البرامج الالكترونية الحديثة، لا توجد فروق ذات دلالة احصائية بين التدريسين من ناحية النوع (ذكر او انثى) وقد تم توصل الباحثة الى العديد من التوصيات والمقترحات .