bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gomastahs, Peons, Police and Chowdranies: The Role of Indian Subordinate in the Functioning of the Lock Hospitals and the Indian Contagious Diseases Act, 1805 to 1889
Authors: Rama Gopalakrishnan Divya 
Published: February 2022

AbstractRecent scholarship on the social history of health and medicine in colonial India has moved beyond enclavist or hegemonic aspects of imperial medicine and has rather focused on the role of Indian intermediaries and the fractured nature of colonial hegemony. Drawing inspiration from this scholarship, the article highlights the significance of the Indian subordinates in the lock hospital system in the nineteenth century Madras Presidency. This study focuses on a class of Indian subordinates called the “gomastah”, who were employed to detect clandestine prostitution in Madras to control the spread of venereal disease. It also underlines the role of other native and non-native subordinates such as Dhais, Chowdranies and Matrons, the ways in which they became indispensable for the smoother operation of the Contagious Diseases Act and the lock hospitals on a day-to-day basis. By emphasising how Indian subordinates were able to bring in caste biases within colonial governmentality, adding another layer to the colonial prejudices and xenophobia against the native population, it underlines the fact that there was not a one-way appropriation or facilitation of the coloniser’s knowledge or biases by the colonised intermediaries. Rather, it argues for an interaction between them, and highlights the complexities of caste hierarchies and prejudice within the everyday colonial governmentality. Moreover, the article focuses on the consequent chaos and inherent power struggle between different factions of colonial staff.
Trends in Adoption of Laparoscopic Appendicectomy in a Developing Country: Closing the Gap
Authors: Naidoo Maheshwar , Thirayan Varun , Kong Victor , Govindasamy Vishendran , Dasrath Ash , Mills Bob , Bruce John , Laing Grant , Clarke Damian 
Published: February 2022

AbstractBackgroundThis study reviews our use of laparoscopic versus open appendicectomy over the last decade to track the trends in their usage in a middle‐income country.MethodsA retrospective study was conducted on patients with intraoperative confirmed acute appendicitis from January 2013 to December 2019 at Grey's Hospital, Pietermaritzburg, South Africa.ResultsEight hundred fifty‐one cases of AA were included. 724 (85%) patients underwent open surgery; 435 (60%) via a midline incision and 194 (27%) via a local incision. 127 (15%) patients underwent laparoscopic appendicectomy. A significant rend was noted for an increasing proportion of surgery performed by laparoscopy compared to open surgery (p = 0.02). Patients who underwent open surgery compared to laparoscopy presented with greater peritonism (48.5% vs. 28%, p < 0.001), delay from symptom onset (3 vs. 2 days, p < 0.001), more frequently from rural areas (94% vs. 86%, p = 0.002) and with higher AAST scores (46.7% AAST ≥ 4, vs. 14.9%, p < 0.001). This former group had significantly greater morbidity (42% vs. 35%, p < 0.001) with higher Clavien‐Dindo scores, were more likely to require ICU admission (8.3% vs. 2.3%, p < 0.001) and have longer hospital stay (4 days vs. 2 days, p < 0.001); no statistically significant difference in mortality was observed (1.1% vs. 0.8%, p = 0.75).ConclusionsThere has been a steady increase in the uptake of laparoscopic appendicectomy and decrease in open approaches in our centre. There is still a high rate of patients with advanced disease, and it is unlikely that this cohort will be suitable for laparoscopic surgery. If we hope to increase the uptake of laparoscopic surgery for acute appendicitis even further, we must focus on identifying patients with early and low‐grade disease.
Synthesis of polymer-vesicle latex particles through an ATRP-based approach
Authors: Loiko Olessya P. , Heuts Johan P. A. , van Herk Alex M. 
Published: February 2022

AbstractThe synthesis of polymer-vesicle latex particles by using extruded vesicles of dimethyldioctadecyl ammonium bromide (DODAB) via an atom transfer radical polymerization–based approach is reported. Cryo-TEM characterization revealed the growth of polymer from one side of the vesicle, and the final morphology of the resulting particles was affected by monomer feed composition. Protrusions or nanocapsules were synthesized when MMA:BA:EGDMA or MMA were used, respectively. Furthermore, it was found that the co-oligomer composition and chain length affect the resulting morphologies of the particles.
Graphical abstract
Clinopyroxene diversity and magma plumbing system processes in an accreted Pacific ocean island, Panama
Authors: Molendijk Sander M. , Buchs David M. , Mason Paul R. D. , Blundy Jonathan D. 
Published: February 2022

AbstractCharacterising equilibrium and disequilibrium crystal-melt processes is critical in determining the extent of magma mixing and crystallization conditions in the roots of volcanoes. However, these processes remain poorly investigated in most Pacific intraplate ocean settings that are difficult to access and study. To help address this issue, we investigated crystallization conditions of clinopyroxene phenocrysts in an accreted Palaeogene oceanic island in Panama. Petrographic and geochemical observations, petrological modelling of major and trace elements, and liquid-mineral multicomponent equilibrium tests were carried out using basalts, picrites, and hawaiites of the transitional tholeiitic shield to alkaline post-shield volcanic stages of the island. Five types of clinopyroxene crystals were identified, including (1) microphenocrysts with micron-scale oscillatory zoning, (2) primitive, yet resorbed picrite-hosted phenocrysts, (3) chemically homogeneous, anhedral crystals found in the remaining basalts, (4) Ti–rich euhedral hawaiite-hosted phenocrysts, and (5) evolved sector-zoned phenocrysts. Liquid-clinopyroxene multicomponent equilibrium tests in combination with textural analysis show that ~ 74% of the studied clinopyroxenes are in possible major element equilibrium with one of the available whole rock magma compositions, of which only 21% are equilibrated with their carrier liquid. To deconvolute clinopyroxene-melt pairings and determine plumbing system conditions, we combine rhyolite-MELTS modelling, geothermobarometry, and major- and trace-element equilibrium evaluations, limiting crystallization conditions to crustal levels (< 23 km depth). No migration of magmatic reservoirs to deeper levels is observed during the shield- to post-shield transition. These results suggest the occurrence of an extensive crystal mush system during the late shield to post-shield volcanic stages of this intraplate volcanic system, with both primitive and evolved crystallization domains sampled during eruptions.
Bedside and laboratory diagnostic testing in myasthenia
Authors: Yoganathan Katie , Stevenson Alexander , Tahir Awais , Sadler Ross , Radunovic Aleksandar , Malek Naveed 
Published: February 2022

AbstractMyasthenia gravis (MG) and congenital myasthenic syndromes (CMS) are a group of disorders with a well characterised autoimmune or genetic and neurophysiological basis. We reviewed the literature from the last 20 years assessing the utility of various neurophysiological, immunological, provocative and genetic tests in MG and CMS. Diagnostic sensitivity of repetitive nerve stimulation test ranges between 14 and 94% and specificity between 73 and 100%; sensitivity of single-fibre EMG (SFEMG) test ranges between 64 and 100% and specificity between 22 and 100%; anti-acetylcholine receptor (AChR) antibody sensitivity ranges from 13 to 97% and specificity ranges from 95 to 100%. Overall, SFEMG has the highest sensitivity while positive anti-AChR antibodies have the highest specificity. Newer testing strategies that have been investigated over the last couple of decades include ocular vestibular-evoked myogenic potentials, otoacoustic emissions and disease-specific circulating miRNAs in serum for autoimmune myasthenia, as well as next-generation sequencing for genetic testing of CMS. While there has been significant progress in developing newer testing strategies for diagnosing MG and CMS over the last couple of decades, more research is needed to assess the utility of these newer tools regarding their sensitivity and specificity.
More than just lipid balls: quantitative analysis of plastoglobule attributes and their stress-related responses
Authors: Arzac Miren I. , Fernández-Marín Beatriz , García-Plazaola José I. 
Published: February 2022

Abstract
Main conclusion
Plastoglobules are ubiquitous under non-stress conditions and their morphology, closely related to their composition, changes differently depending on the specific stress that the plant undergoes.

Abstract
Plastoglobules are lipoprotein structures attached to thylakoid membranes, which participate in chloroplast metabolism and stress responses. Their structure contains a coating lipid monolayer and a hydrophobic core that differ in composition. Their function in chloroplasts has been studied focussing on their composition. However, we currently lack a comprehensive study that quantitatively evaluates the occurrence and morphology of plastoglobules. Following a literature search strategy, we quantified the main morphological attributes of plastoglobules from photosynthetic chloroplasts of more than 1000 TEM images published over the last 53 years, covering more than 100 taxa and 15 stress types. The analysis shows that plastoglobules under non-stress conditions are spherical, with an average diameter of 100–200 nm and cover less than 3% of the chloroplast cross-section area. This percentage rises under almost every type of stress, particularly in senescence. Interestingly, an apparent trade-off between increasing either the number or the diameter of plastoglobules governs this response. Our results show that plastoglobules are ubiquitous in chloroplasts of higher plants under non-stress conditions. Besides, provided the specific molecular composition of the core and coat of plastoglobules, we conclude that specific stress-related variation in plastoglobules attributes may allow inferring precise responses of the chloroplast metabolism.
A hands-on tutorial on network and topological neuroscience
Authors: Centeno Eduarda Gervini Zampieri , Moreni Giulia , Vriend Chris , Douw Linda , Santos Fernando Antônio Nóbrega 
Published: February 2022

AbstractThe brain is an extraordinarily complex system that facilitates the optimal integration of information from different regions to execute its functions. With the recent advances in technology, researchers can now collect enormous amounts of data from the brain using neuroimaging at different scales and from numerous modalities. With that comes the need for sophisticated tools for analysis. The field of network neuroscience has been trying to tackle these challenges, and graph theory has been one of its essential branches through the investigation of brain networks. Recently, topological data analysis has gained more attention as an alternative framework by providing a set of metrics that go beyond pairwise connections and offer improved robustness against noise. In this hands-on tutorial, our goal is to provide the computational tools to explore neuroimaging data using these frameworks and to facilitate their accessibility, data visualisation, and comprehension for newcomers to the field. We will start by giving a concise (and by no means complete) overview of the field to introduce the two frameworks and then explain how to compute both well-established and newer metrics on resting-state functional magnetic resonance imaging. We use an open-source language (Python) and provide an accompanying publicly available Jupyter Notebook that uses the 1000 Functional Connectomes Project dataset. Moreover, we would like to highlight one part of our notebook dedicated to the realistic visualisation of high order interactions in brain networks. This pipeline provides three-dimensional (3-D) plots of pairwise and higher-order interactions projected in a brain atlas, a new feature tailor-made for network neuroscience.
Austria-based real-world data on bevacizumab in newly diagnosed epithelial ovarian cancer
Authors: Tsibulak Irina , Polterauer Stephan , Reinthaller Alexander , Schauer Christian , Berger Jürg , Marth Christian 
Published: February 2022

Summary
Background
Front-line maintenance therapy with bevacizumab demonstrates high efficacy and safety in epithelial ovarian cancer, as already shown in large phase III trials; however, the corresponding study populations are often not fully representative of patients in clinical routine. In this Austria-based multicenter study, we aimed to explore the real-world outcomes of bevacizumab use in front-line treatment of ovarian cancer, including patients with comorbidities and poor performance status.

Patients
This study is an open label single arm multicenter noninterventional trial and included patients with newly diagnosed advanced epithelial ovarian cancer, who were treated with platinum-based chemotherapy and were candidates for receiving bevacizumab according to the product label. Data collection started in the third quarter of 2012 and ended in the third quarter of 2018.

Results
In this study 50 patients were included and 575 adverse events were reported for 90% of the patients. The majority of the adverse events were mild (47%) or moderate (37%). The most common adverse events were hypertension (60%), anemia (48%), leukopenia (42%), thrombocytopenia (36%), neutropenia (36%) and proteinuria (26%). A relation to bevacizumab was documented only for 10.3% of all adverse events. In almost 50% of all adverse events, no intervention was needed and bevacizumab treatment had to be interrupted only in 3.3% of all adverse events. The median progression-free survival was 1.3 years (95% CI 1.1–1.8).

Conclusion
The routine use of front-line bevacizumab for advanced ovarian cancer is associated with high efficacy comparable with that obtained in randomized phase III clinical trials; however, hypertension and proteinuria were reported significantly more often in our Austria-based real-world population.
Complications after surgical treatment of pelvic fractures: a five-year follow-up of 194 patients
Authors: Lundin Natalie , Enocson Anders 
Published: February 2022

Abstract
Purpose
Surgical treatment of pelvic fractures is an advanced intervention associated with multiple complications. The primary aim of this study was to investigate the rate of unplanned reoperations after pelvic fracture surgery. Secondary aims included occurrence of other adverse events and mortality.

Methods
All adult patients ≥ 18 years with surgically treated pelvic fracture operated at the Karolinska University Hospital in Sweden between 2010 and 2019 were identified and retrospectively included. Data were collected through review of medical records and radiographs. Logistic regression analysis was performed to evaluate factors associated with unplanned reoperations and other adverse events.

Results
A total of 194 patients were included with mean age (± SD, range) 45.4 (16, 18–83) years. 62% were males (n = 121) and the median (IQR) follow-up time was 1890 (1791) days (4.9 years). Forty-eight patients (25%) had an unplanned reoperation, with infection being the most common cause of reoperation (n = 18, 9.3%). Seventy-eight (40%) patients had an adverse event not requiring reoperation and the most common event was nerve injury (n = 34, 18%). Concomitant abdominal injury was identified as a risk factor for an adverse event (OR 2.5, 95% CI 1.3–4.9, p < 0.01). 30-day mortality was 1.5% and 1-year mortality 6.2%.

Conclusion
The rate of unplanned reoperation after pelvic fracture surgery was high, as was the rate of other adverse events not requiring surgery. No identified risk factor was found to predict further surgery, but concomitant abdominal injury was a risk factor for other adverse events. Mortality was low at both 30 days and 1 year.
The Critical Space for Orthogonally Invariant Varieties
Authors: Ottaviani Giorgio 
Published: February 2022

AbstractLet q be a nondegenerate quadratic form on V. Let X ⊂ V be invariant for the action of a Lie group G contained in SO(V,q). For any f ∈ V consider the function df from X to $\mathbb C$
ℂ
defined by df(x) = q(f − x). We show that the critical points of df lie in the subspace orthogonal to ${\mathfrak g}\cdot f$
g
⋅
f
, that we call critical space. In particular any closest point to f in X lie in the critical space. This construction applies to singular t-ples for tensors and to flag varieties and generalizes a previous result of Draisma, Tocino and the author. As an application, we compute the Euclidean Distance degree of a complete flag variety.
Early experience with the ARTISENTIAL® articulated instruments in laparoscopic low anterior resection with TME
Authors: Darwich I. , Abuassi M. , Aliyev R. , Scheidt M. , Alkadri M. A. , Hees A. , Demirel-Darwich S. , Chand M. , Willeke F. 
Published: February 2022

Abstract
Background
The notion of articulation in surgery has been largely synonymous with robotics. The ARTISENTIAL® instruments aim at bringing advanced articulation to laparoscopy to overcome challenges in narrow anatomical spaces. In this paper, we present first single-center results of a series of low anterior resections, performed with ARTISENTIAL®.

Methods
Between September 2020 and August 2021, at the Department of Surgery, St. Marienkrankenhaus Siegen, Siegen, Germany, patients with cancer of the mid- and low rectum were prospectively enrolled in a pilot feasibility study to evaluate the ARTISENTIAL® articulated instruments in performing a laparoscopic low anterior resection. Perioperative and short-term postoperative data were analyzed.

Results
Seventeen patients (10 males/7 females) were enrolled in this study. The patients had a median age of 66 years (range 47–80 years) and a median body mass index of 28 kg/m2 (range 23–33 kg/m2). The median time to rectal transection was 155 min (range 118–280 min) and the median total operative time was 276 min (range 192–458 min). The median estimated blood loss was 30 ml (range 5–70 ml) and there were no conversions to laparotomy. The median number of harvested lymph nodes was 15 (range 12–28). Total mesorectal excision (TME) quality was ‘good’ in all patients with no cases of circumferential resection margin involvement (R0 = 100%). The median length of stay was 9 days (range 7–14 days). There were no anastomotic leaks and the overall complication rate was 17.6%. There was one unrelated readmission with no mortality.

Conclusions
Low anterior resection with ARTISENTIAL® is feasible and safe. All patients had a successful TME procedure with a good oncological outcome. We will now seek to evaluate the benefits of ARTISENTIAL® in comparison with standard laparoscopic instruments through a larger study.
Effects of unilateral dynamic handgrip on reaction time and error rate
Authors: Mirifar Arash , Luan Mengkai , Ehrlenspiel Felix 
Published: February 2022

AbstractQuick and accurate reactions to environmental stimuli are often required. Researchers have investigated ways to improve these reactions, which are critical components of perceptual-motor abilities. To optimize individual performance, different techniques, such as embodied interventions and brain stimulation, have been examined. The evidence from EEG studies shows that upper limb muscle contractions lead to changes in brain oscillations associated with changes in mental states and behavioral outcomes. Much research has been conducted on whether muscle contractions of a particular hand have a greater effect on a perceptual-motor ability, as a trigger to facilitate cortical processes (a mediator) for skilled motor performance. While previous studies have shown that left- (vs. right-) hand contractions can lead to greater alpha activation, we hypothesized that left dynamic handgrips have different impacts on motor performance, reflected by simple RT (SRT) and choice RT (CRT). We recruited 64 right-handers, for a within/between-subjects experiment consisting of performance measurements in SRT and CRT tasks after the intervention (either right or left dynamic handgrip approximately twice a second for 30 s for each hand) or assignment to paired passive control groups. We did not find left-hand contractions improve response accuracy in neither SRT nor CRT tasks. Further, left-hand contractions did not affect RTs. The findings indicate that the effects of dynamic handgrips are smaller on behavioral outcomes such as RTs than what can be inferred from published studies. More research is needed to establish the effect of dynamic handgrips on optimizing performance.
Student, Teacher, and Scientist Views of the Scientific Enterprise: An Epistemic Network Re-analysis
Authors: Peters-Burton Erin E. , Dagher Zoubeida R. , Erduran Sibel 
Published: February 2022

AbstractThere is substantial research in science education about students’, teachers’, and scientists’ views of nature of science (NOS). Many studies have used NOS frameworks that focus on particular ideas such as tentativeness of scientific knowledge and cultural embeddedness of science. In this paper, we investigate NOS from the perspective of the Family Resemblance Approach (FRA) which considers clusters of ideas about science in terms of categories that offer a comprehensive analytical lens to studying NOS views. The empirical study re-analyzes NOS views obtained from 7 and 8th grade students, science teachers, and scientists using the FRA lens. Statements from all three groups were obtained using a free-write questionnaire on nature of knowledge and nature of knowing. The statements were reclassified using the FRA framework. Epistemic network analysis (ENA) was applied to the statements produced by each group of participants, and the resulting network models were interpreted and compared. The results show that student and teacher network models possessed no central idea, and more tangible ideas about science were frequently connected. Scientist network models showed more connections across their statements which indicate a higher degree of agreement and coherence among a variety of ideas compared to student and teacher network models. The paper discusses the findings as well as the methodological contributions, and concludes with implications for future research.
Representations of student performance data in local education policy
Authors: Prøitz Tine Sophie , Novak Judit , Mausethagen Sølvi 
Published: February 2022

AbstractThe use of data for governance purposes has been widely recognised as a way for national authorities to coordinate their activities across administrative levels and improve educational quality. This places the mid-central authority—in many countries the municipal level—in the midst of modern education governing. This article reports a case study analysis of the particular uses of performance data and numbers by mid-central municipal authorities in the daily work of governing schools in Norway. The three empirical case studies combine an analysis of policy document and fieldwork interviews with municipal administrators. The article contributes important insights into the role of municipal administrators as interpreters of policy goals at a crucial yet understudied level of the education system. In contrast to the dominant perspective in the data use literature, which often addresses implementation and the effectiveness of how numbers and data can be ideally designed and used, the results provide grounds for a more nuanced understanding of the institutional processes related to setting performance goals.