bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative progression of brain metastasis is associated with seizures
Authors: Wolpert Fabian , Grossenbacher Bettina , Moors Selina , Lareida Anna , Serra Carlo , Akeret Kevin , Roth Patrick , Imbach Lukas , Le Rhun Emilie , Regli Luca , Weller Michael , Galovic Marian 
Published: July 2022

AbstractSeizures in patients with brain metastases have an impact on morbidity and quality of life. The influence of tumor growth on the risk of seizures in these patients is not well defined. In this cohort study, we evaluated adult patients from the University Hospital of Zurich following resection of brain metastases from solid tumors, with or without preoperative seizures, at 3, 6, 9, and 12 months postoperatively. Brain magnetic resonance imaging was assessed for tumor progression using the Response Assessment in Neuro‐Oncology criteria. The quarterly risk of unprovoked seizures was modeled with mixed effects logistic regression. We analyzed 444 time frames in 220 patients. Progression of brain metastases was independently associated with seizures during the respective quarterly follow‐up period (odds ratio = 3.9, 95% confidence interval = 1.3–11.3, p = .014). Complete resection of brain metastases was associated with a lower risk of seizures (odds ratio = .2, 95% confidence interval = .04–.7, p = .015). Postoperative progression of brain metastases quadrupled the risk of seizures; therefore, vigorous follow‐up may be useful to identify tumor progression and gauge the risk of seizures. The identification of patients at high seizure risk may have implications for treatment decisions and influence aspects of daily life. Breakthrough seizures may indicate brain metastases progression.
Duodenoduodenal intussusception in a 16‐year‐old German Warmblood mare
Authors: Mathys Rebecca , Graubner Claudia , Kaiponen Taina , Grau‐Roma Llorenç , Van der Vekens Elke , Koch Christoph , Brünisholz Hervé 
Published: July 2022

SummaryA 16‐year‐old German Warmblood mare was presented with an acute history of abdominal pain that failed to respond to medical treatment. Diagnostic evaluations including transabdominal and transrectal ultrasound and palpation were suggestive of a small‐intestinal intussusception. Exploratory laparotomy revealed a duodenoduodenal intussusception of the proximal and middle third of the duodenum. The horse was subjected to euthanasia due to the poor prognosis. The post‐mortem examination showed the intussusception to be associated with a pseudodiverticulum orally to the intussusception and duodenal muscular hypertrophy.
Promoting physical activity for people with haemophilia in the age of new treatments
Authors: Matlary Ruth Elise D. , Grinda Nathalie , Sayers Fionnuala , Versloot Olav , McLaughlin Paul ,   EAHAD Physiotherapists Committee
Published: July 2022

AbstractHaemophilia treatment has seen great advances in recent years with an accompanied reduced risk of physical activity (PA) related bleeds. Based on its known health benefits, people with haemophilia (PWH) are currently encouraged to regularly engage in PA. However, this may not always translate to increased levels of PA. In this narrative review we aim to provide a brief overview of what is currently understood regarding PA levels and influences for the three broad age groups of children and adolescents, adults and older adults. We also provide recommendations for members of the haemophilia team on important aspects related to promotion of PA in their clinical practice. We highlight that PA behaviour is multifactorial and that many PWH still have limited access to adequate care. Whilst some still face unique challenges to being more physically active, overall, the barriers and facilitators to activity are very similar to that of the general population.
Exercise capacity in people with haemophilia: A systematic review
Authors: Cruz‐Montecinos Carlos , Núñez‐Cortés Rodrigo , Vasconcello‐Castillo Luis , Solís‐Navarro Lilian , Carrasco‐Alonso Bernardita , Calatayud Joaquín , Pérez‐Alenda Sofía , Torres‐Castro Rodrigo 
Published: July 2022

AbstractIntroductionExercise capacity has been established as a protective factor against joint impairment in people with haemophilia (PWH). However, little is known about how exercise capacity is affected in PWH.AimTo analyse exercise capacity, as assessed by standardised laboratory or field tests in PWH.MethodsA systematic review was conducted to identify manuscripts investigating physical capacity in PWH. An electronic search of PubMed/MEDLINE, Embase, Web of Science, CENTRAL and CINAHL was conducted from inception to 13 April, 2022. Two independent reviewers performed data extraction and assessed study quality using the critical appraisal tools of the Joanna Briggs Institute.ResultsNineteen studies with 825 patients were included. Most studies used the six‐min walk test (6MWT) or peak/maximal oxygen consumption (VO2max). In children, the distance walked ranged from 274 ± 36.02 to 680 ± 100 m. In adults, the distance walked ranged from 457.5 ± 96.9 to 650.9 ± 180.3 m. VO2max ranged from 37 ± 8 to 47.42 ± 8.29 ml kg–1 min–1. Most studies reported lower values of exercise capacity compared to standardised values. Overall, the quality of the studies was moderate.ConclusionMost of the studies showed that PWH have lower exercise capacity compared to reference values of 6MWT or VO2max. Based on these results, it is necessary to emphasise in both the promotion and the prescription of physical exercise in PWH.
In vitro effect on the proteolytic activity of papain with proteins of the skin as substrate
Authors: Trevisol Thalles Canton , Henriques Rosana Oliveira , Cesca Karina , Souza Ana Júlia Antunes , Furigo Agenor 
Published: July 2022

AbstractObjectiveThis work aims to evaluate the effects of enzyme concentration, pH, temperature and time course degree of hydrolysis (DH) of papain regarding further development of pharmaceutical and cosmetic formulations.MethodsThe hydrolysis of casein, collagen, keratin and porcine skin at pH and temperature ranges of the human skin was evaluated. Also, low contact times of enzyme–substrate were studied. The incorporation of 3mM of cysteine improved the caseinolytic (PU), collagenolytic (CU) and keratinolytic (KU) activities of papain. Results: In general, the increase from 0.1 to 1.0 or 2.0 mgmL−1 of papain improved PU, CU and KU. When 2.0 mgmL−1 of papain was used, the highest DH of casein, collagen and keratin was obtained at 240min (14%, 35% and 6% respectively). The decrease in pH and temperature reduced all proteolytic activities, but papain maintained at least 50% and 40% of its activity at 26°C and pH 4.5 respectively. Scanning electron micrographs of the surface of the skin showed that papain application had exfoliating activity.ConclusionThis preformulation study demonstrated that papain concentration, time of application and pH of the product should be evaluated when developing a product to promote the hydrolysis of the proteins of the skin.
Evaluation of functional and bioactive properties of crude gill extract of Tor putitora using different assays
Authors: Rehman Gauhar , Sardar Sumbal , Alkhateeb Mariam Abdulaziz , Mohamed Rania Ali El Hadi , Abd Al Galil Fahd Mohammed , Hamayun Muhammad , Shahjeer Kiran , Iqbal Toheed , Ahmed Nazeer , Nawaz Taufiq , Ullah Rafi 
Published: July 2022

SummaryFor centuries, natural products isolated from animals, plants and microbes have been the centre of attention for the world's scientific community for their role in eradicating and reducing many diseases. The present research work is also performed on the crude gill extract of Tor putitora named TPG‐Ex to analyse its various functional and bioactive properties. A total of five different biological assays were performed. Two assays performed were the free radical scavenging assays having other free radical generators such as DPPH and H2O2. Different concentrations of extract were used in both assays. The maximum scavenging ability in the Antioxidant DPPH assay was 59.42% at 50 μL. In the H2O2 radical scavenging assay, the maximum scavenging ability of TPG‐Ex recorded was 55.46% at a concentration of 50 μL. The antiangiogenic potential of the TPG‐Ex CAM assay was assessed, which also showed maximum inhibition of neovascularisation at a concentration of 80 μL. The antidiabetic potential of TPG‐Ex was also revealed after processing the extract through glucose uptake by yeast cells assay and glucose adsorption assay. TPG‐Ex indicated maximum glucose uptake at a concentration of 20 μg of 56.61%.
Shelf‐life determination of an egg‐based cake, relating sensory attributes microbiological characteristics and physico‐chemical properties
Authors: Moura‐Alves Márcio , Machado Carolina , Silva José A. , Saraiva Cristina 
Published: July 2022

SummaryThe study of sensory, microbiological and physical–chemical properties are important in local products where the level of inspection and quality control are low. The present study aimed to determine the shelf‐life of an egg‐based moist cake, relating sensory, microbiological and physical–chemical properties. Slices of Cavacas de Resende were collected, stored at two different temperatures (7 and 22 °C) and analysed over time (0, 6 h, 1, 2, 4, 7 and 10 days). Salmonella, Bacillus cereus, Listeria monocytogenes and Escherichia coli, were not detected. On 10 days of storage at 22 °C results were above the allowed limit for Staphylococcus aureus. The counts of mesophiles, moulds and yeasts exceeded the allowed limits in the last days of storage at 22 °C. Most of sensory variables presented a positive and highly significant correlation with freshness, with emphasis to brightness (crust and batter), moist, softness and succulence. Hardness and fracturability (both instrumental) showed a highly significant correlation with sensory freshness. Loss of moisture and mould development were main factors for product quality decrease. Better conservation of the product was achieved at 7 °C with a shelf‐life limit of 7 days. At 22 °C, it is recommended to consume the product in 3 days.
Translation and validation of 17‐item Wound‐QoL questionnaire in a Chinese population
Authors: Liu Jin , Li Huijuan , Zhang Peiying , Bai Rui , Fu Xiaojin , Guan Hui , Wen Bing , Ding Yanming , Qi Xin 
Published: July 2022

AbstractWe aimed to translate the 17‐item questionnaire to measure the quality of life of patients with chronic wounds (Wound‐QoL‐17) and verify its reliability and validity in the Chinese population. The standard Chinese version of the Wound‐QoL‐17 was determined through translation, back translation, and cultural adaptation. A total of 121 patients with chronic wounds from the wound center of a tertiary hospital in Beijing were recruited. Through a questionnaire and physical examination, we tested the criterion‐related validity, known group validity, structural validity, internal consistency coefficient (Cronbach's alpha), and test–retest correlation. A new structure of four factors was extracted by exploratory factor analysis, and the cumulative contribution rate was 72.23%. The total score and that of the four factors, which were significantly correlated with the EuroQol Five Dimensions Questionnaire (EQ‐5D) and the Short Form‐36 Health Survey (SF‐36) (P < 0.05), also showed statistically significant differences between patients with different pain grades, with or without wound odour, and between different groups of patients reporting wound changes in the past 2 weeks. Cronbach's alpha was between 0.779 and 0.906, while the test–retest reliability was between 0.532 and 0.802. We concluded that the Chinese Wound‐QoL‐17 has good reliability and validity and is suitable for evaluating the quality of life of patients with chronic wounds.
Environmental fate and behaviour of antibiotic resistance genes and small interference RNAs released from genetically modified crops
Authors: Un Jan Contreras Sandra , Gardner Courtney M. 
Published: July 2022

Abstract
Rising global populations have amplified food scarcity across the world and ushered in the development of genetically modified (GM) crops to overcome these challenges. Cultivation of major crops such as corn and soy has favoured GM crops over conventional varieties to meet crop production and resilience needs. Modern GM crops containing small interference RNA molecules and antibiotic resistance genes have become increasingly common in the United States. However, the use of these crops remains controversial due to the uncertainty regarding the unintended release of its genetic material into the environment and possible downstream effects on human and environmental health. DNA or RNA transgenes may be exuded from crop tissues during cultivation or released during plant decomposition and adsorbed by soil. This can contribute to the persistence and bioavailability in soil or water environment and possible uptake by soil microbial communities and further passing of this information to neighbouring bacteria, disrupting microbial ecosystem services such as nutrient cycling and soil fertility. In this review, transgene mechanisms of action, uses in crops, and knowledge regarding their environmental fate and impact to microbes are evaluated. This aims to encapsulate the current knowledge and promote further research regarding unintended effects transgenes may cause.
Using critical family theorizing and intersectional feminist praxis to navigate reflexive conversations on race and power in academic settings
Authors: Russon Jody M. , Allen Katherine R. , Few‐Demo April L. , Pease Jenene Case 
Published: July 2022

AbstractConversations related to racism, antiblackness, and oppression have expanded over the past years in response to the deaths of George Floyd, Breonna Taylor, and many others. As family scholars, we recognize the impact of the legacy of violence against Black and Brown people and are at a point in history where the United States is struggling to address ramifications of unacknowledged race‐based traumas. Critical intersectional feminist praxis suggests conscious dialogue about antiracism is one place in which change can occur. As such, we used critical family theorizing to navigate a four‐part group discussion on addressing antiblackness among Human Development and Family Science (HDFS) faculty and doctoral students. As an exercise in reflexivity, this article translates theory into action through the reflections of four colleagues who had diverse roles in facilitating these conversations. We anchored strategies for interrogating institutional White supremacy through examining antiblackness and intentional engagement of equitable institutional practices.
Policy Uncertainty and Bank Mortgage Credit
Authors: KARA GAZI I. , YOOK YOUNGSUK 
Published: July 2022

AbstractWe document that banks reduce the supply of mortgage loans when policy uncertainty increases in their headquarter states as measured by the timing of U.S. gubernatorial elections. The reduction is larger for term‐limited elections and close elections. We utilize high‐frequency, geographically granular loan‐level data to address an identification problem arising from changing local loan demand: (i) we estimate a difference‐in‐difference specification with state/time or county/time fixed effects; (ii) banks reduce lending outside their home states as well when their home states hold elections; and (iii) we observe important cross‐sectional differences in the way banks with different characteristics respond to policy uncertainty.
STING mediates neuroinflammatory response by activating NLRP3‐related pyroptosis in severe traumatic brain injury
Authors: Zhang Li‐Min , Xin Yue , Wu Zhi‐You , Song Rong‐Xin , Miao Hui‐Tao , Zheng Wei‐Chao , Li Yan , Zhang Dong‐Xue , Zhao Xiao‐Chun 
Published: July 2022

AbstractLong‐term neurological deficits after severe traumatic brain injury (TBI), including cognitive dysfunction and emotional impairments, can significantly impair rehabilitation. Glial activation induced by inflammatory response is involved in the neurological deficits post‐TBI. This study aimed to investigate the role of the stimulator of interferon genes (STING)–nucleotide‐binding oligomerization domain‐like receptor pyrin domain‐containing‐3 (NLRP3) signaling in a rodent model of severe TBI. Severe TBI models were established using weight‐drop plus blood loss reinfusion model. Selective STING agonist ADU‐S100 or antagonist C‐176 was given as a single dose after modeling. Further, NLRP3 inhibitor MCC950 or activator nigericin, or caspase‐1 inhibitor VX765, was given as an intracerebroventricular injection 30 min before modeling. After that, a novel object recognition test, open field test, force swimming test, western blot, and immunofluorescence assays were used to assess behavioral and pathological changes in severe TBI. Administration of C‐176 alleviated TBI‐induced cognitive dysfunction and emotional impairments, neuronal loss, and inflammatory activation of glia cells. However, the administration of STING agonist ADU‐S100 exacerbated TBI‐induced behavioral and pathological changes. In addition, STING activation exacerbated pyroptosis‐associated neuroinflammation via promoting glial activation, as evidenced by increased cleaved caspase‐1 and GSDMD N‐terminal expression. In contrast, the administration of C‐176 showed anti‐pyroptotic effects. The neuroprotective effects of C‐176 were partially reversed by the NLRP3 activator, nigericin. Collectively, glial STING is responsible for neuroinflammation post‐TBI. However, pharmacologic inhibition of STING led to a remarkable improvement of neuroinflammation partly through suppressing NLRP3 signaling. The STING–NLRP3 signaling is a potential therapeutic target in TBI‐induced neurological dysfunction.image
Morphology of the antegonial notch and its utility in the determination of sex on skeletal materials
Authors: Mączka Grzegorz , Kulus Michał , Grzelak Joanna , Porwolik Michał , Dobrzyński Maciej , Dąbrowski Paweł 
Published: July 2022

AbstractA number of criteria for the assessment of biological sex, which are applied to living or recently deceased individuals, have been developed, such as genetic, chromosomal, gonadal, hormonal, and phenotypic criteria. Features of a metric and descriptive nature are used to assess the sex of skeletal materials. The diagnostic features of the skull are concentrated in the craniofacial region and around the eye sockets. The mandible is a diagnostically important part of the skull, on which a complex of features is visible. These features develop up to the third decade of life. The goal of the research was to assess the suitability of the parameters of the preangular notch, in other words, the length, height, and surface area for sex prediction applied to skeletal materials. The study included computed tomography images of the masticatory system of 194 patients, consisting of 83 females and 111 males, aged from 16 to 93 years. The three straight lines which correspond to the sides of the triangle representing the notch, in addition to its height, were determined and measured digitally. The receiver operating characteristic method was used to assess the usefulness of the studied features for the purposes of sex prediction. The sensitivity of the test ranged from 51.4% to 67% for the parameters of the preangular notch on the right‐hand side, and from 44.4% to 80.2% on the left‐hand side. The most reliable predictive models were obtained for two features (shown in the graphical abstract). However, when taking into account, the specificity and sensitivity of the tests presented here, only the length of side AB (a basal length of the notch) can be regarded as a feature that supports the assessment of sex on the basis of other diagnostic features of the mandible. The size and shape of the preangular notch should be treated as auxiliary features in the assessment of sex. For this reason, it is recommended that they should be applied simultaneously to the set of features described in the section on anthropological standards.
Partitioning of urban networks with polycentric congestion pattern for traffic management policies: Identifying protected networks
Authors: Jiang Shang , Keyvan‐Ekbatani Mehdi , Ngoduy Dong 
Published: July 2022

AbstractLarge‐scale urban networks are usually loaded heterogeneously with a polycentric congestion pattern, resulting in a highly scattered network macroscopic fundamental diagram (NMFD or MFD). Thus, researchers have tried to partition city networks into homogeneous subzones. In this study, a six‐step partitioning algorithm is proposed. The framework allows the NMFD information to be used. It combines traffic variables and geographic connectivity to obtain partitions. The framework includes graph definition, data preprocessing, feature handling, clusters and partitions identification, and boundaries reshaping. Tests on a simplified grid network and the city of the Melbourne road network demonstrate the suitability of the framework for characterizing the traffic states by the partitions. The framework on the missing data scenarios and monocentric and polycentric traffic concentrations scenarios, as well as applying multiple data types, has been challenged. Thereafter, parameter impact analysis demonstrates that manipulation of the parameters enables users to find the desired partitions. Last but not least, a comparison with an existing method also implies the uniqueness and efficiency of the developed framework.
Capillary pathology with prominent basement membrane reduplication is the hallmark histopathological feature of scleromyositis
Authors: Ellezam Benjamin , Leclair Valérie , Troyanov Yves , Bersali Imane , Giannini Margherita , Hoa Sabrina , Bourré‐Tessier Josiane , Nadon Valérie , Drouin Julie , Karamchandani Jason , O'Ferrall Erin , Lannes Béatrice , Satoh Minoru , Fritzler Marvin J. , Senécal Jean‐Luc , Hudson Marie , Meyer Alain , Landon‐Cardinal Océane 
Published: July 2022

AbstractAimsWe aim to perform ultrastructural and histopathological analysis of muscle biopsies from a large group of systemic sclerosis (SSc) patients, including some with early/mild SSc features, and examine whether capillary pathology differentiates ‘scleromyositis’ (SM) from other auto‐immune myositis (AIM) subsets.MethodsMuscle biopsies from a total of 60 SM patients and 43 AIM controls from two independent cohorts were examined by electron microscopy, collagen‐4 immunofluorescence (Col4IF) and routine light microscopy.ResultsUltrastructural examination revealed prominent capillary basement membrane (BM) reduplication (4+ layers in >50% of capillaries) in 65% of SM vs 0% of AIM controls (p < 0.001). In SM cases without prominent BM reduplication, capillary dilation was the most distinctive feature, present in 8% of capillaries in SM vs 2% in controls (p = 0.001). Accumulation of ensheathed pericyte processes was another characteristic feature of SM and closely correlated with the degree of BM reduplication (r = 0.833, p < 0.001). On light microscopy, BM marker Col4IF revealed more frequent capillary enlargement in SM than in controls (84% vs 21%, p < 0.001). SM cases were classified as non‐inflammatory myopathy (36%), non‐specific myositis (33%) or immune‐mediated necrotizing myopathy (31%), but despite this histopathological heterogeneity, prominent BM reduplication remained a constant finding. In the 16 SM patients with early/mild SSc features, 63% showed prominent BM reduplication.ConclusionsThese results show that capillary pathology, and in particular prominent capillary BM reduplication, is the hallmark histopathological feature of SM even in patients with early/mild SSc and support the concept of SM as an organ manifestation of SSc and a distinct subset of AIM.