bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 2D equivalent mechanical model of the whole pelvic floor and impairment simulation
Authors: Xie Jiachen , Li Song , Yao Tingqiang , Shen Jihong 
Published: October 2022

AbstractWe developed a complete 2D equivalent mechanical model of the pelvic floor based on magnetic resonance imaging (MRI) images of a 35‐year‐old healthy woman. This model can simulate anterior vaginal prolapse (AVP) due to soft tissue impairment. Thus, we can study the mechanism of prolapse formation from a mechanical perspective and improve the assessment and treatment of the condition in clinical practice. Based on 2D MRI image parameter measurements and computer‐aided design methods, the 2D equivalent mechanical model of the whole pelvic floor in the sagittal plane was accurately reconstructed, which includes all necessary tissues of the pelvic floor system. Material parameters were mainly from the literature. We simulated the impairment by reducing the tissue's mechanical properties, and numerical simulations predicted the mechanical response and morphological changes of the healthy and impaired pelvic floor in different states. In six intra‐abdominal pressure (IAP) states (8.4–208.9 cmH2O), the maximum cervical descent in the impaired pelvic floor was 0.3–18.521 mm, which was much greater than that in the healthy pelvic floor (0.14–6.55 mm). Once the impairment occurred (0%–25%), there was a significant increase in maximum displacement, stress, and cervical descent (30.9–36.5 mm, 0.56–1.12 MPa, 4.6–12.1 mm), and a clinically similar prolapse shape occurred. Simple supine and standing will not cause prolapse. The formation of prolapse is closely related to vaginal tissue impairment. In the standing position, the main forces on the healthy pelvic floor system are distributed horizontally posteriorly and inferiorly, reducing the burden in the vertically downward direction.
Hypnosis on patients treated with adjuvant chemotherapy for breast cancer: A feasibility study
Authors: Fabbro Michel , Jacot William , Jarlier Marta , Guiu Séverine , D'Hondt Véronique , Pouderoux Stéphane , Champoiral Patrice , Janiszewski Chloé , Nicklès Isabelle 
Published: October 2022

AbstractBackgroundAcceptability and tolerance of chemotherapy on patients treated for breast cancer remain challenging. Complementary approaches such as hypnosis may have a favorable impact both at the time of announcing and during chemotherapy, due to the notorious anxiety, distress, and self‐perceived dysfunction. The objective of the study was that the patients complied with at least four self‐hypnosis sessions out of the six cycles of chemotherapy.MethodsThis open, prospective longitudinal study assessed feasibility of compliance to self‐hypnosis during chemotherapy in an outpatients setting. Training sessions were given by a hypnotherapist. Throughout each cycle of chemotherapy, the patient had to use self‐hypnosis to better control her anxiety or any difficulties. Nurses could offer help to the patient. Chemotherapy‐associated side effects were evaluated through the NCI‐Common Toxicity Criteria for Adverse Events v 4.03; moreover, side effects as pain, nausea, vomiting, fatigue, and anxiety were also evaluated during chemotherapy using a visual analogic scale. Health‐related quality of life, emotional distress (anxiety and depression), and cancer‐related fatigue were assessed (at inclusion, end of chemotherapy and 3 months later) using the EORTC QLQ‐C30 and QLQ‐BR23, HADS and MFI‐20 questionnaires, respectively. The number of patients screened and actually included in the study was reported, as the reasons for refusal.ResultsThirty‐five patients were included with a median age of 55 years (35–78). All patients received a hypnosis training session. The overall compliance with self‐hypnosis was 68.6% (95% CI: 50.7%–83.2%), meaning that more than two thirds of patients performed at least four sessions of self‐hypnosis. According to NCI‐CTCAE, Grade 2 nausea and vomiting was observed in 45.7% and 22.9%, respectively, Grade 2 fatigue in 62.9%. Based on the HADS questionnaire, anxiety increased at the end of the chemotherapy and returned to the initial value 3 months later (p = .97) whereas depression significantly decrease 3 months after the end of chemotherapy with respect to the inclusion (p = .003). Role, emotional, and cognitive functioning were slightly affected throughout the treatment, in contrast to dyspnea or physical functioning.ConclusionOur study showed that self‐hypnosis was feasible on patients newly diagnosed for breast cancer receiving chemotherapy.
Trajectories of interpersonal problems in residential eating disorder treatment: Exploring the influence of primary diagnosis
Authors: Harris Bethany A. , Scharff Adela , Smith Melanie , Brooks Gayle , Thompson‐Brenner Heather , Boswell James F. 
Published: October 2022

AbstractBaseline interpersonal problems have been associated with treatment outcome in eating disorders (ED) and are important for understanding ED maintenance and aetiology. Despite this evidence, little is known about trajectories of change in interpersonal problems in the context of treatment, particularly in intensive ED treatment. This study examined the trajectory of total interpersonal problems in residential ED treatment, as well as two subdomains previously highlighted in ED research of being overly Cold (interpersonally distant) or overly Domineering (interpersonally controlling), as a function of different primary presenting ED diagnoses: anorexia nervosa restricting subtype (AN‐R), binge‐purge subtype (AN‐BP), and bulimia nervosa or binge eating (BN/BED). Interpersonal problem data were collected at admission, discharge, and 6‐month follow‐up. Trajectories were analysed with multilevel models. Results showed small‐to‐medium statistically significant reductions in interpersonal problems across diagnostic groups from admission to discharge for total interpersonal scores, and gains appeared to be maintained at follow‐up for both AN groups. Patients diagnosed with primary AN experienced steeper declines in total interpersonal problems from admission to follow‐up compared with patients diagnosed with BN/BED, with AN‐R experiencing the steepest trajectory. Planned contrasts indicated anyone with relevant binge eating behaviours had higher average levels of both Cold, as well as Domineering problems. Exploratory contrasts suggested that patients who had more Domineering problems also exhibited more binge symptoms and were typically slower to improve. Overall, results suggest interpersonal problems are generally malleable in residential ED treatment, yet change patterns differ by presenting ED symptoms and interpersonal problem subdomain.
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients
Authors: Zhang Zhichang , Ji Weiping , Huang Jin , Zhang Yawen , Zhou Yan , Zhang Jianjun , Dong Yang , Yuan Ting , Yang Qingcheng , Ding Xiaomin , Tang Lina , Li Hongtao , Yin Junyi , Wang Yonggang , Ji Tong , Fei Jia , Zhang Bing , Chen Peizhan , Hu Haiyan 
Published: October 2022

AbstractPurposeMalignant pleural effusion (MPE) is an adverse prognostic factor in patients with osteoblastic osteosarcoma; however, the cellular contexts of MPE are largely unknown.Experimental designWe performed single‐cell RNA‐sequencing (scRNA‐seq) on 27 260 cells from seven MPE samples and 91 186 cells from eight osteosarcoma tissues, including one recurrent, one lung metastasis and six primary tumour (PT) samples, to characterize their tumour microenvironment.ResultsThirteen main cell groups were identified in osteosarcoma tumour and MPE samples. Immune cells dominate the cellular contexts in MPE with more T/NK cells and less osteoclasts compared to PT samples. Of T/NK cells, CD8+GNLY+, CD8+KLRC2+ T cells and FCGR3A+NK cells were enriched in MPE but CD4+FOXP3+ Tregs were enriched in PT samples. Naïve IGHD+ B and immune regulatory IGHA1+ B cells were largely identified in MPE, whereas bone metabolism‐related CLEC11A+ B cells were significantly enriched in osteosarcoma PT. M2‐type TAMs, including CLEC11A_TAM, C1QC_TAM and Prolif_TAMs, among myeloid cells were enriched in PT, which may suppress cytotoxicity activities of T cells through multiple ligand–receptor interactions. Mature LAMP3+ DCs were transformed from CD1C+ DC and CLEC9A+ DC sub‐clusters when exposure to tumour alloantigens, which may improve T cell cytotoxicity activities on tumour cells under anti‐PD‐L1 treatments. In further, immune cells from MPE usually present up‐regulated glycolysis and down‐regulated oxidative phosphorylation and riboflavin metabolism activities compared to those in PT samples.ConclusionsOur study provided a novel cellular atlas of MPE and PT in patients with advanced osteosarcoma, which may provide potential therapeutic targets in the future.
Cell of origin is not associated with outcomes of relapsed or refractory diffuse large B cell lymphoma
Authors: Desai Sanjal H. , Mwangi Raphael , Smith Alexandra N. , Maurer Matthew J. , Farooq Umar , King Rebecca L. , Cerhan James R. , Feldman Andrew L. , Habermann Thomas M. , Thompson Carrie A. , Wang Yucai , Ansell Stephen M. , Witzig Thomas E. , Nowakowski Grzegorz S. 
Published: October 2022

AbstractActivated B cell (ABC) type diffuse large B cell lymphoma (DLBCL), double hit lymphoma (DHL) and double expressor lymphoma (DEL) have poor outcomes to frontline R‐CHOP but impact of these molecular features on outcomes of relapsed/refractory (R/R) disease is not well‐characterized. We evaluated the association of diagnostic cell of origin (COO), double hit and double expressor status with overall survival after first relapse in DLBCL patients who were enrolled into the Molecular Epidemiology Resource (MER) cohort. COO was available from immunohistochemistry (IHC) using Hans criteria or gene expression profiling (GEP) (Nanostring) on the diagnostic FFPE biopsy. Of 373 pts with R/R DLBCL, 278 had COO by IHC: 152 were GCB, 107 were non‐GCB. One hundred and fourty had COO by GEP: 44 were ABC, 65 were GCB and 13 were unclassifiable. Nineteen out of 163 (12%) were DHL; 30 out of 135 (22%) had DEL. COO, either by IHC (2 years OS GCB: 45% [CI95: 38–54] vs. non‐GCB: 44% [CI95:36–55], p > 0.05) or GEP (2 years OS ABC: 42% [CI95: 29–59] vs. GCB: 40% [CI95: 30–54], p > 0.05), was not associated with difference in OS. DHL (2 years OS 16 [CI95:6–45] vs. 45% [CI95: 34–59], p < 0.01) and DEL (2 years OS 33% [CI95: 20–56], vs. 50% [CI95: 41–60], p < 0.05) had lower OS than non‐DHL and non‐DEL/non‐DHL counterparts, respectively. COO by IHC or GEP was not associated with OS in R/R DLBCL while DHL and DEL were adverse prognostic markers in DLBCL at first relapse.
DNA methylation biomarkers for noninvasive detection of triple‐negative breast cancer using liquid biopsy
Authors: Manoochehri Mehdi , Borhani Nasim , Gerhäuser Clarissa , Assenov Yassen , Schönung Maximilian , Hielscher Thomas , Christensen Brock C. , Lee Min Kyung , Gröne Hermann‐Josef , Lipka Daniel B. , Brüning Thomas , Brauch Hiltrud , Ko Yon‐Dschun , Hamann Ute 
Published: October 2022

AbstractNoninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for earlier detection of triple‐negative breast cancer (TNBC) which could help clinicians with easier and more efficient treatment options. We evaluated genome‐wide DNA methylation data derived from TNBC and normal breast tissues, peripheral blood of TNBC cases and controls and reference samples of sorted blood and mammary cells. Differentially methylated regions (DMRs) between TNBC and normal breast tissues were stringently selected, verified and externally validated. A machine‐learning algorithm was applied to select the top DMRs, which then were evaluated on plasma‐derived circulating cell‐free DNA (cfDNA) samples of TNBC patients and healthy controls. We identified 23 DMRs accounting for the methylation profile of blood cells and reference mammary cells and then selected six top DMRs for cfDNA analysis. We quantified un‐/methylated copies of these DMRs by droplet digital PCR analysis in a plasma test set from TNBC patients and healthy controls and confirmed our findings obtained on tissues. Differential cfDNA methylation was confirmed in an independent validation set of plasma samples. A methylation score combining signatures of the top three DMRs overlapping with the SPAG6, LINC10606 and TBCD/ZNF750 genes had the best capability to discriminate TNBC patients from controls (AUC = 0.78 in the test set and AUC = 0.74 in validation set). Our findings demonstrate the usefulness of cfDNA‐based methylation signatures as noninvasive liquid biopsy markers for the diagnosis of TNBC.
Impact of peripartum antibiotics on wound complications in women with obstetric anal sphincter injury
Authors: Propst Katie , Yao Meng , Hickman Lisa C. 
Published: October 2022

AbstractObjectiveTo evaluate the role of antibiotics on preventing wound complications following obstetric anal sphincter injuries (OASI).MethodsThis is a cohort study with retrospective and prospective components of women who sustained an OASI at vaginal delivery. The primary objective of this study was to assess the impact of prophylactic antibiotics at the time of delivery on perineal wound complications. Women were grouped based on peripartum antibiotic administration: no antibiotics (NABX), antibiotics for OASI wound complication prophylaxis (PABX), antibiotics for therapeutic indications (TABX), and antibiotics for any indication (AABX, PABX + TABX).ResultsFour hundred and twenty‐five women with OASI were included in this analysis. Most women experienced a third‐degree perineal laceration (358, 84.2%). One hundred and sixteen (27.3%) women received NABX, 195 (45.9%) women received PABX, and 114 (26.8%) women received TABX. Cefazolin was the most common antibiotic in the PABX group. Perineal wound complications occurred in 51 (12.0%) women: 14 (12.4%) in NABX, 26 (13.3%) in PABX, 11 (9.6%) in TABX, and 37 (12.0%) in AABX. The incidence of perineal wound complications did not differ between groups.ConclusionsIn this cohort study, peripartum antibiotics did not reduce wound complication incidence following OASI. It is likely that a first‐generation cephalosporin is not the ideal antibiotic in this clinical setting.
Comment on “Feasibility of Raman spectroscopy as a potential in vivo tool to screen for pre‐diabetes and diabetes”
Authors: Bratchenko Ivan A. , Bratchenko Lyudmila A. 
Published: October 2022

AbstractThis paper comments recent findings about Raman spectroscopy application for in vivo noninvasive diabetes detection, published in the Journal of Biophotonics by E. Guevara et al. (J. Biophotonics 2022, 15, e202200055). The proposed results may be not entirely correct due to possible overestimation of classification models and absence of additional information regarding age of tested volunteers.
Association between rs1799971 in the mu opioid receptor gene and methadone maintenance treatment response
Authors: Xie Xiaohu , Gu Jun , Zhuang Dingding , Zhou Yun , Chen Xiaoyu , Shen Wenwen , Li Longhui , Liu Yue , Xu Wenjin , Hong Qingxiao , Xu Zemin , Chen Weisheng , Zhou Wenhua , Liu Huifen 
Published: October 2022

AbstractObjectiveGenetic variations can affect individual response to methadone maintenance treatment (MMT) for heroin addiction. The A118G variant (rs1799971) in the mu opioid receptor gene (OPRM1) is a potential candidate single nucleotide polymorphism (SNP) for personalized MMT. This study determined whether rs1799971 is related to MMT response or dose.MethodsWe recruited 286 MMT patients from a Han Chinese population. The rs1799971 genotype was determined via TaqMan genotyping assay. The genetic effect of this SNP on MMT response or dose was evaluated using logistic regression. A meta‐analysis was performed to merge all available data to evaluate the role of rs1799971 in MMT using RevMan 5.3 software.ResultsNo statistical significance was observed in the association between the OPRM1 rs1799971 and MMT response or dose in our Chinese cohort. Meta‐analysis indicated that the OPRM1 A118G variation was not significantly associated with MMT response or dose requirement.ConclusionThe results suggest that rs1799971 in OPRM1 might not play a critical role alone in influencing MMT response or dose.
Fetal brain biometry and cortical development after maternal SARS‐CoV‐2 infection in pregnancy: A prospective case–control study
Authors: Mappa Ilenia , Pietrolucci Maria Elena , Pavjola Maqina , Maruotti Giuseppe , D'Antonio Francesco , Rizzo Giuseppe 
Published: October 2022

AbstractObjectivesTo assess cerebral growth and the development of fetal cortex using neurosonography in fetuses from pregnancies experiencing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) according to infection timing.MethodsPregnancies with by SARS‐CoV‐2 during first and second trimesters were prospectively studied and matched with unaffected controls. Enclosed women underwent neurosonography at 30–34 weeks of gestation and corpus callosum (CC) and cerebellar vermis (CV) lengths measured. Further Sylvian fissure (SF), insula. Parieto‐occipital fissure (POF), and calcarine sulci fissures (CSF) depths were obtained. The ultrasonographic variables considered were normalized with fetal head size.ResultsOne hundred and seventy four consecutive pregnancies experiencing SARS COV 2 infection (81 before 14 weeks and 93 later) and 131 not affected pregnancies were considered. General and pregnancy characteristics were similar between the three groups of women. No significant differences existed in CC and CV lengths across groups. Similarly, insula, SF, POF And CSF depth did not result changed in fetuses of affected mothers.ConclusionsSARS‐CoV‐2 infection does nor resulted associate with differential fetal cortical development or brain growth in mildly symptomatic pregnant women. This information may be useful to reassure infected mothers on the health of their fetuses.
Ultrasound‐promoted1,3‐dipolarcycloaddition of azomethine yields for synthesis of dispiropyrrolidineoxindole derivatives in hexyltriphenylphosphonium bromide as an ionic liquid, and the evaluation of their anti‐cancer activity
Authors: Matloubi Moghaddam Firouz , Hosseinzadeh Nouraddin , Safari Fatemeh , Foroumadi Alireza 
Published: October 2022

AbstractA green, effortless, and protective one‐pot three‐component process for the synthesis of derivatives using cycloadition catching azomethineylides in situ created by means of decarboxylative build‐up of sarcosine and isatin has been developed in hexyltriphenylphosphonium bromide (HTPB) as an ionic liquid and recyclable solvent in supreme yield without the use of a catalyst under ultrasonic irradiation. This method offers mild reaction conditions, excellent products yields in shorter reaction times, ease of operation and environmentally friendly process and high ragio and stereoselectivity. The anticancer activity of all new compounds has been investigated against four cell lines. Also, the structures were authenticated by both spectroscopic techniques and signal crystal X‐ray analysis.
Intersession Repeatability of Diffusion‐Tensor Imaging in the Supraspinatus and the Infraspinatus Muscles of Volunteers
Authors: Tous Cyril , Jodoin Alexandre , Grabs Detlev , Van Houten Elijah , Bureau Nathalie J. 
Published: October 2022

BackgroundQuantifying the rotator cuff (RC) muscles' viscoelasticity could provide outcome relevant information in patients with RC tears. MR‐elastography requires robust diffusion‐tensor imaging (DTI) to account for tissue anisotropy in muscles stiffness computation.PurposeTo assess the repeatability of DTI parameters in the supraspinatus and infraspinatus muscles and to explore DTI tractography conformity with the muscles' anatomy.Study TypeProspective.SubjectsSix healthy volunteers underwent three consecutive shoulder MRI sessions about 10 minutes apart.Field Strength/Sequence3T/T1‐vibe Dixon and Spin echo EPI DTI (12 gradient encoding directions, b‐values 500 and 800 sec/mm2).AssessmentSupraspinatus and infraspinatus muscles were segmented on the T1‐vibe Dixon sequence. DTI image quality was assessed using a quantitative threshold based on the signal‐to‐noise ratio (SNR). The eigenvalues (), fractional anisotropy (FA) and mean diffusivity were calculated. DTI tractography was visually assessed.Statistical TestsDTI parameters within‐subject intersession repeatability was assessed with Bland–Altman analysis and the coefficient of variation (CV). Repeatability was considered good for CV < 10%.ResultsThe SNR between diffusion‐weighted and non‐diffusion‐weighted images was greater than 3, which aligns with standards for estimating DTI parameters. The FA showed the lowest mean bias (−0.007; 95% confidence interval [CI] −0.031 to 0.018) whereas the λ1 had the highest mean bias (0.146 × 10−3 mm2/sec; CI −0.034 to 0.326 × 10−3 mm2/sec). CVs of the DTI parameters varied between 3.5% (FA) and 8.4% (λ3) for the supraspinatus and between 3.2% (λ1) and 6.8% (λ3) for the infraspinatus. Tractography provided muscle fiber representations in three‐dimensional space concordant with RC anatomy.Data ConclusionDTI of the supraspinatus and infraspinatus muscles achieved an adequate SNR, allowing the measurement of the DTI metrics with good repeatability, and thus can be used for optimizing stiffness estimation in these anisotropic tissues.Evidence Level2Technical EfficacyStage 2
Amendment with controlled release urea increases leaf morpho‐physiological traits, grain yield and NUE in a double‐cropping rice system in southern China
Authors: Liu Chuang , Sun Yixiang , Wu Gang , Wang Xiao , Yuan Manman , Wang Jiabao , He Weizhu , Chen Fang , LeCocq Kate , Wang Li , Liu Yi 
Published: October 2022

AbstractBACKGROUNDUnderstanding of mechanisms that underpin high‐yielding cropping systems is essential for optimizing management practices. Currently, the contribution of plant traits such as leaf area, chlorophyll content and intercepted photosynthetically active radiation (PARi) to yield and nitrogen use efficiency (NUE) are not fully understood. In addition, the understanding of how canopy traits are affected by nitrogen (N) management practices is unclear. The present study aimed to determine the effect of amendment with controlled release urea (CR), common urea or no urea on NUE and plant eco‐physiological characteristics in a 2‐year field study in a double rice cropping system.RESULTSRegulation of N release through amendment with CR significantly increased grain yield, NUE and leaf morpho‐physiological attributes. CR coupled with common urea (at comparable total N rates) increased leaf area index (LAI), relative chlorophyll content index (CCI) and PARi, leading to higher grain yield and NUE (increased 24.4% and 25.3% in early and late rice, respectively) compared to local farming practice. Structural equation model (SEM) analysis showed that differences in N application, between CR and common urea, directly accounted for differences observed in soil nutrient, PARi and NUE rather than yield components. Additionally, compared to traditional yield determinants, LAI and PARi (between booting and filling stage) are capable of predicting and explaining grain yield by 0.69 and 0.92 of R2 in early and late rice, respectively.CONCLUSIONLeaf morpho‐physiological traits are important for developing N management practices to increase NUE and improve food security for paddy agriculture in southern China. © 2022 Society of Chemical Industry.