bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excited State Transient Phenomena in Two Different Phases of the Photoactive MOF MIP‐177(Ti)
Authors: Kuila Aneek , Diez‐Cabanes Valentin , Melillo Arianna , Gosch Jonas , Dhakshinamoorthy Amarajothi , Yao Shilin , Mouchaham Georges , Serre Christian , García Hermenegildo , Navalon Sergio , Durrant James R. , Maurin Guillaume , Paz Yaron 
Published: February 2025

AbstractThe metal organic framework (MOF) MIP‐177(Ti) is under the spotlight for its robust photo‐response and stability. This MOF can be synthesized in forms: MIP‐177(Ti)‐LT (LT: low temperature) and MIP‐177(Ti)‐HT (HT: high temperature). The MIP‐177(Ti)‐LT version comprises of Ti12O15 units interconnected by 3,3′,5,5′‐tetracarboxydiphenylmethane (mdip) ligands and interconnecting formate groups. Upon high temperature treatment, MIP‐177(Ti)‐LT loses its formate groups, thus rearranging into a continuous 1‐D chain of Ti6O9 units leading to the MIP‐177(Ti)‐HT. Based on this 1‐D connected structure, one should expect a higher catalytic activity of MIP‐177(Ti)‐HT. Nevertheless, the hydrogen evolution reaction photoactivity assessment clearly indicates the opposite. Combining transient IR measurements (TRIR), TAS and DFT/TD‐DFPT calculations unveils the reasons for this situation. The TRIR measurements evidence that the photoinduced electrons are located in the inorganic part, while the holes are in the mdip ligand. The longer lifetime of MIP‐177(Ti)‐LT is mapped onto a slower decay of the Ti–O related peaks. A reversible change in the coordination of the carboxylate groups from a bidentate to a monodentate coordination is observed only in MIP‐177(Ti)‐LT. Complementary DFT and TD‐DFPT simulations demonstrate a higher electron delocalization on the inorganic part for MIP‐177(Ti)‐LT (hence, enhanced mobility and slower recombination), thus explaining its superior photocatalytic activity.
Cellular Spatial Sensing Determines Cell Mechanotransduction Activity on the Aligned Nanofibers
Authors: Sun Qian , Qiu Tiecheng , Liu Xiaojing , Wei Qiang 
Published: February 2025

AbstractThe geometric properties of extracellular matrix (ECM) fibers play a crucial role in regulating cellular behaviors and functions. Although extensive research has examined the effects of fiber alignment, conflicting results have often arisen, leaving the precise mechanisms by which electrospun fiber alignment affects cellular behavior still unclear. This study investigates how the arrangement of polycaprolactone (PCL) electrospun fiber substrates affects cellular mechanosensing by modulating cell positioning. Larger cells, whose width on a coverslip exceeds 5 times the width of the aligned fiber gaps (≈8 µm in this study) and that span multiple aligned fibers, demonstrate enhanced spreading and mechanotransduction. Conversely, smaller cells, whose width is less than or equal to 2.5 times the width of the aligned fiber gaps and are confined within fiber interstices, exhibit limited mechanotransductive signaling. These findings are further supported by manipulating cell size and, more importantly, have led to the fabrication of semi‐aligned fiber networks that enhance both cell spreading and mechanotransduction. This research emphasizes the importance of optimizing fiber architecture to improve cellular interactions, offering valuable insights for the design of biomimetic scaffolds in tissue regeneration.
Whole‐Component Antigen Nanovaccines Combined With aTIGIT for Enhanced Innate and Adaptive Anti‐tumor Immunity
Authors: Wang Weitao , Wu Haitao , Zhang Xuan , Hong Yang , Tao Shi , Cao Xiangjing , Wang Shipeng , Zha Lisha , Zha Zhengbao 
Published: February 2025

AbstractUsing entire tumor cells or tissues that display both common and patient‐specific antigens can potentially trigger a comprehensive and long‐lasting anti‐tumor immune response. However, the limited immunogenicity, low uptake efficiency, and susceptibility to degradation of whole‐component antigens present significant challenges. In this study, we employed tumor lysates (TLs) as whole‐component antigens, in conjunction with MgAl‐layered double hydroxide (MA) as nanoadjuvants and Mn2+ as immunostimulants, to create personalized MMAT (Mn2+‐MA‐TLs) nanovaccines. After subcutaneous injection of MMAT nanovaccines, the high local concentrations of TLs and Mn2+ facilitated the recruitment and activation of antigen‐presenting cells (APCs), thereby inducing a robust adaptive immune response. Remarkably, MMAT nanovaccines enabled lysosomal escape, enhanced antigen cross‐presentation, and activated the cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) pathway in APCs. Furthermore, MMAT nanovaccines, when combined with the anti‐TIGIT monoclonal antibody (aTIGIT), an immune checkpoint inhibitor, not only stimulated T‐cell‐based adaptive anti‐tumor immune responses but also activated the NK‐cell‐based innate anti‐tumor immunity, effectively suppressing tumor growth, recurrence, and metastasis. Thus, the ternary MMAT nanovaccines developed here introduced a pioneered paradigm for the rapid preparation of whole‐component tumor antigens with nanoadjuvants and immunostimulants into nanovaccines, offering new prospects for clinical immunotherapies.
“Frozen” Ionogels with High and Tunable Toughness for Soft Electronics
Authors: Li Feiyang , Wu Kefan , Zhang Xian , Fu Yuanmao , Sun Taolin , Guo Honglei , Wang Xiaolin , Guo Hui , Meng Yuezhong 
Published: February 2025

AbstractAs a promising material, ionogels have garnered increasing interest in various applications including flexible electronics and energy storage. However, most existing ionogels suffer from poor mechanical properties. Herein, an effective and universal strategy is reported to toughen ionogels by freezing the polymer network via network design. As a proof of concept, an ionogel is readily prepared by copolymerization of isobornyl acrylate (IBA) and ethoxyethoxyethyl acrylate (CBA) in the presence of ionic liquid, resulting in a bicontinuous phase‐separated structure. The rigid, ionic liquid‐free PIBA segments remain frozen at service temperature and serve as a load‐bearing phase to toughen ionogels, while the flexible PCBA phases maintain high ionic liquid content. As a result, the mechanical properties of ionogels are noticeably improved, showing high rigidity (48.5 MPa), strength (4.19 MPa), and toughness (8.19 MJ · m−3). Moreover, ionogels also exhibit remarkable thermo‐softening performance, strong adhesiveness, high conductivity, shape memory properties, and satisfactory biocompatibility. When used as an ionic skin, the ionogel can not only respond to different deformation but also accurately and consistently detect body motions over long periods. This novel strategy in toughening ionogels can pave the way for the development of various tough and stable ionotronic devices.
Enhancing resilience with natural growth targeting
Authors: Orphanides Athanasios 
Published: February 2025

AbstractDespite a number of helpful changes, including the adoption of an inflation target, the Fed's monetary policy strategy proved insufficiently resilient in recent years. While the Fed eased policy appropriately during the pandemic, it fell behind the curve during the post‐pandemic recovery. During 2021, the Fed kept easing policy while the inflation outlook was deteriorating and the economy was growing considerably faster than the economy's natural growth rate—the sum of the Fed's 2% inflation goal and the growth rate of potential output. The resilience of the Fed's monetary policy strategy could be enhanced, and such errors be avoided with guidance from a simple natural growth targeting rule that prescribes that the federal funds rate during each quarter be raised (cut) when projected nominal income growth exceeds (falls short) of the economy's natural growth rate. An illustration with real‐time data and forecasts since the early 1990s shows that Fed policy has not persistently deviated from this simple rule with the notable exception of the period coinciding with the Fed's post‐pandemic policy error.
Experimental and numerical study on seismic behavior of double‐inclined reinforced concrete beam‐column joints
Authors: Shen Xinyu , Zhang Chao , Liu Kun , Zhu Zhan , Liu Chengtao 
Published: February 2025

AbstractThe adoption of diamond‐shaped pylons leads to double‐inclined beam‐column joints (BCJs), whose seismic behavior and shear strengths have not been studied. In this work, one regular and three double‐inclined BCJs were tested to investigate the effects of column inclination and column axial load level on the seismic behavior of BCJs. Besides, parametric analysis based on a finite element model was also conducted to further reveal the effects of key parameters on the joint shear strengths of double‐inclined BCJs. Results indicated that the column inclination led to initial stress on the column and joint core, accelerating the joint cracking and damage development. Compared to the regular BCJ, the inclined BCJ showed reduced loading capacity, joint shear strength, ductility, and viscous damping. Furthermore, the behavior of double‐inclined BCJs was evidently affected by the column axial load. A higher column axial load could change the failure mode from joint shear to mixed joint shear and column flexure, leading to improved loading capacity, ductility, energy dissipation, and joint shear strength. Meanwhile, the joint shear strengths of the inclined BCJs were effectively improved by adopting higher concrete strength, while the benefits of increasing the joint stirrup ratio were relatively limited.
Electrocatalysts for Hydrogen Production – Catalyst Design Strategies Based on Crystal Structures of Multimetal Oxides
Authors: Sugawara Yuuki , Yamaguchi Takeo 
Published: February 2025

AbstractSolid‐state crystalline multimetal oxides have been widely studied for their applications as electrode materials, e. g., in fuel cells, water electrolyzer, lithium‐ion batteries, and metal‐air batteries. Particularly, hydrogen production via water electrolysis is considered a key technology for realizing a sustainable circular carbon society. Enhancing the activity of electrocatalysts is a critical challenge for improving the efficiency of the water electrolysis technology. Thus, strategies for designing prominent catalyst materials have drawn considerable attention. Our group has been conducting research aimed at establishing comprehensive design strategies for the rational and rapid development of highly active catalysts. In this Personal Account, we present our research efforts on enhancing the activity of cost‐efficient nonprecious metal‐based oxide catalysts for the oxygen evolution reaction at the anode of water electrolysis. Specifically, we propose design strategies based on crystal structures of multimetal oxides and demonstrate how these strategies have contributed to the development of highly active electrocatalysts.
Maternal Exposure of SD Rats to Benzo[a]Pyrene Impairs Neurobehavior and Hippocampal Synaptic Ultrastructure in Offspring via Downregulating Synaptic‐Associated Factors
Authors: Zhang Yu , Guo Yuting , Du Linhu , Zhao Junxiu , Ci Xiaorui , Yin Jinzhu , Niu Qiao , Mo Yiqun , Zhang Qunwei , Nie Jisheng 
Published: February 2025

ABSTRACTBenzo[a]pyrene (B[a]P) is a carcinogenic contaminant widely present in the environment. Recently, increasing studies have paid attention to the developmental neurotoxicity of B[a]P in offspring in their early life stages; however, the underlying molecular mechanisms have not been clearly elucidated. In this study, we aimed to evaluate the effects of prenatal B[a]P exposure on neurobehavior of pups during their brain growth spurt (BGS) period and also explore the potential underlying mechanisms. Pregnant Sprague‐Dawley (SD) rats were intraperitoneally exposed to 0, 10, 20, or 40 mg/kg‐bw B[a]P for three consecutive days during embryonic days 17–19. The physiological development index of pups was observed, and a series of neurobehavioral tests assessing sensory and motor maturation were performed. The complexity of dendritic branches and the basal dendritic spine density of CA1 pyramidal neurons were examined using Golgi‐Cox staining during PND 1–14. In addition, the mRNA and protein expression levels of hippocampal BDNF, SYP, Arc, PSD‐95, DNMT1, and DNMT3a, and the level of 5‐mC were detected using RT‐qPCR, Western blotting, or immunohistochemical staining, respectively. We noted that prenatal B[a]P exposure induced body weight loss and neurobehavioral impairments in the early life stages. Furthermore, this study firstly revealed that maternal exposure to B[a]P impaired the dendritic arborization and complexity of pyramidal neurons in the hippocampus CA1 subfield in offspring during the early postnatal period, and the damage of B[a]P to basal dendritic spine density was also observed in a dose‐dependent manner. Correspondingly, maternal exposure to B[a]P markedly reduced BDNF, Arc, SYP, and PSD‐95 mRNA and protein levels in the offspring hippocampus. Meanwhile, the levels of hippocampal DNMT1, DNMT3a, and 5‐mC significantly increased in the offspring prenatally exposed to B[a]P. In summary, this study firstly demonstrated that maternal B[a]P exposure induced neurobehavioral deficits by destroying the hippocampal synaptic ultrastructure, which was possibly associated with the downregulation of BDNF, Arc, SYP, and PSD95 in the hippocampus through increased DNMTs‐mediated DNA methylation in offspring during the BGS period.
Effect of hormonal therapy on satisfaction rates after penile prosthesis surgery in prostate cancer survivors
Authors: Jacob Jerril , Khalafalla Kareim , Desai Ishav , Wang Run 
Published: February 2025

AbstractBackgroundProstate cancer, a prevalent malignancy in men, often results in erectile dysfunction (ED), particularly following treatments like radical prostatectomy (RP) and radiotherapy, significantly affecting quality of life. Managing ED in prostate cancer survivors is critical. Inflatable penile prosthesis (IPP) implantation is a well‐established treatment for ED, yet the literature on satisfaction rates for patients with a history of androgen deprivation therapy (ADT) remains sparse. We aimed to investigate the impact of ADT on satisfaction rates in patients undergoing IPP implantation following RP or radiation therapy (XRT).MethodsA retrospective review of 529 patient charts identified 96 eligible patients who underwent IPP implantation post‐prostate cancer treatment and completed the 11‐item Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire. Patients were stratified into two groups based on ADT status, and their satisfaction scores were compared. Effect sizes were used to assess clinical relevance alongside statistical significance (p = 0.0344).ResultsPatients receiving ADT had significantly lower EDITS scores (p = 0.0344) compared to those not on ADT. RP patients reported higher satisfaction post‐IPP compared to XRT patients, even after controlling for ADT. Additionally, coronary artery disease (CAD) was associated with lower satisfaction scores.ConclusionADT significantly lowers patient satisfaction post‐IPP, with RP patients generally reporting higher satisfaction than XRT patients. These findings highlight the importance of counseling prostate cancer patients on ADT's impact on long‐term sexual satisfaction and suggest areas for further research to enhance outcomes.
Interpretable Artificial Intelligence for Analysing Changes in Gases in the Uterine Environment of Cows According to Physiological Structures in the Ovary
Authors: Risvanli Ali , Tanyeri Burak , Yildirim Güngör , Tatar Yetkin , Gedikpinar Mehmet , Kalender Hakan , Safak Tarik , Yuksel Burak , Karagulle Burcu , Yilmaz Oznur , Barut Cebrail , Kilinc Mehmet Akif 
Published: February 2025

ABSTRACTThe objective of the present study was to examine the relationship between the gases in a cow's uterine environment and its ovarian physiological structures using the sunflower optimisation algorithm (SFOA) deployed in a device called Metrisör, developed by our project team. A total of 500 uteruses obtained from slaughtered cows served as the experimental sample. Gas measurements were taken from 489 uteruses with no clinical metritis or microbiological growth. Additionally, the diameters of the corpus luteum and follicles in the ovaries were measured using callipers. These results were then analysed based on the presence or absence of a corpus luteum (CL) and follicles larger or smaller than 1.5 cm. According to uterine gas fluctuations, the presence and absence of CL could be detected at rates of 80.60% and 79.60%, respectively. Also, based on uterine gas changes, the presence of ovarian follicles larger than 1.5 cm was determined 82% of the time, and the presence of follicles smaller than 1.5 cm was determined 80% of the time. In conclusion, it was found that different stages of a cow's sexual cycle might involve changes in uterine gases. Thus, the data from this study may enable the development of a new estrus detection method for cows.
Soil Masing Behaviour for Offshore Wind Turbines—Fatigue Design and a Simple Damping Model
Authors: Ryan Gerard V. , Adcock Thomas A.A. , McAdam Ross A. 
Published: February 2025

ABSTRACTFatigue damage accumulation for offshore wind turbines is highly dependent on damping of the structure and particularly on the soil damping contribution during idling conditions. This paper presents an efficient method to estimate soil damping specific to wind turbine design and offshore environmental conditions. The method assumes a narrow‐banded response, suitable for turbines in low damping conditions. The proposed method demonstrates that soil damping varies significantly with load level and that predictions can be improved over the common industry practice of assuming a constant soil damping value. The fatigue damage predicted using this proposed method is calibrated using a multi‐surface plasticity foundation model. The structural response with this plasticity model is also compared to linear elastic soil modelling without any soil damping. This analysis shows that significant reductions in damage may be observed when soil Masing behaviour is incorporated. Overall, this paper shows that soil plasticity, and its variation with load level, should be included within a design framework and suggests a straightforward way of doing so.
Schockraumauslastung in deutschen Traumazentren
Authors: Schindler Cora R. , Pavlu Florian , Faul Philipp , Störmann Philipp , Bieler Dan , Schweigkofler Uwe 
Published: February 2025

Zusammenfassung

Einleitung
Der Gemeinsame Bundesausschuss (G-BA) veröffentlichte im April 2018 eine Regelung zu einem gestuften System von Notfallstrukturen an Krankenhäusern (nach Sozialgesetzbuch V) und legte damit die Grundsätze für Notfallversorgung im stationären Sektor fest. Die Strukturanforderungen für die Versorgung von potenziell Schwerverletzten wird primär durch die Fachgesellschaft definiert und bedeutet eine hohe personelle Vorhaltung bei gleichzeitig jährlich zunehmender Auslastung bei steigenden Patientenzahlen. Ziel der Studie ist es, die tatsächliche Auslastung der traumatologischen Schockräume in zertifizierten Traumazentren zu erfassen.

Methodik
Hierzu wurde eine deutschlandweite Online-Umfrage unter 619 zertifizierten Traumazentren DGU® durchgeführt, um die Häufigkeit der Schockraumalarmierungen zu quantifizieren. Die Ergebnisse wurden retrospektiv mit den Daten aus den Jahresberichten 2021 und 2022 des TraumaRegister DGU® verglichen.

Ergebnisse
Die beteiligten Kliniken meldeten im Jahr 2021 22.479 und im Jahr 2022 24.366 Schockraumalarmierungen (Rücklaufquote der Online-Antworten von 24,1 %). Von diesen Alarmierungen entfielen 70 % auf überregionale Traumazentren. Die Vergleichsanalyse zeigte, dass die realen Fallzahlen 3‑ bis 5‑mal höher sind als die im TR-DGU® dokumentierten Daten. 80 % der Schockräume wurden aufgrund geringer Verletzungsschwere nicht im Register erfasst.

Zusammenfassung
Die Studie belegt die Diskrepanz zwischen der dokumentierten und der tatsächlichen Auslastung der Schockräume in deutschen Traumazentren und betont die Notwendigkeit, die finanzielle und personelle Berücksichtigung der Traumazentren an die reale Inanspruchnahme anzupassen, um eine weiterhin hohe Versorgungsqualität zu gewährleisten.

Graphic abstract
Optimization of thermal conduction welding parameters in LPBFM for enhanced adhesion control
Authors: Simon Joshua , Redlich Tobias , Wulfsberg Jens-Peter 
Published: February 2025

Abstract
Laser powder bed fusion of metals (LPBFM) is an additive manufacturing process in which powdered alloy is selectively fused together to form near net shape parts. A method is proposed which optimizes parameters for the thermal conduction process window to omit lack of fusion defects. The approach takes into account: material, geometry, and previously experimentally derived robust process parameters. It entails experiments to calibrate and qualify the model to enable fine-tuning of process parameters for laser scan vectors to compensate for changing boundary conditions throughout the build. The objective is to satisfy defined adhesion conditions for the solidified melt tracks of each laser scan vector. The method transforms the build job preparation of LPBFM into an optimization problem. The required precision of model result is calculated based on adhesion conditions for the melt tracks and requirements derived for manufacturing model usage on the shop floor. The work contributes to a model-based quality assurance of LPBFM technology.
A randomised controlled trial comparing three clinical administration strategies in spectral detector CT pulmonary angiography with low contrast medium dose
Authors: Kristiansen Cathrine Helgestad , Thomas Owen , Nyquist Anton Bengt , Sanderud Audun , Boavida Joao , Geitung Jonn Terje , Tran Thien Trung , Lauritzen Peter Mæhre 
Published: February 2025

Abstract

Objectives
To compare vascular attenuation (VA) with three strategies for administering a low contrast medium (CM) dose in dual-layer spectral detector CT pulmonary angiography (CTPA).

Methods
Patients were prospectively randomised into control- or one of two experimental groups. Control group patients received CM (350 mgI/mL) diluted 1:1 with saline. Experimental group B received CM (350 mgI/mL) with low flow. Experimental group C received CM with low concentration (140 mgI/mL). Virtual monoenergetic images at 40 and 55 kiloelectron Volt (keV) were reconstructed. Objective examination quality (OEQ) i.e., VA, noise, and signal-to-noise ratio, was measured and subjective examination quality (SEQ) was rated at three anatomical levels: in the pulmonary trunk (PT), the interlobar arteries and the posterior basal segmental arteries. Primary outcome: VA in PT at 40 keV. Secondary outcomes: OEQ and SEQ across all anatomic levels.

Results
A total of 328 patients were randomised. 112 vs 115 and 101 were analysed in the control (A) vs experimental groups (B and C), respectively. There were no differences in VA in PT between the groups: A vs B (p = 0.96), B vs C (p = 0.14), and A vs C (p = 0.18). Group C showed higher VA across all anatomical levels. There were no differences in SEQ.

Conclusion
There was no difference in the attenuation in the PT between the dilution-, low flow-, and low concentration groups. However, the low concentration group showed higher attenuation in the pulmonary arteries when all anatomical levels were assessed.

Key Points

Question

Contrast medium reduction may be accomplished with dilution, low flow, or low concentration. However, the effect of the different strategies on vascular attenuation is unknown.

Findings

There was no difference in pulmonary trunk attenuation between the three strategies on spectral detector CT pulmonary angiography.

Clinical relevance

Low contrast medium dose spectral detector CT pulmonary angiography may be implemented with the administration strategy of the unit’s own choice.