bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a multidisciplinary self-management education programme for kidney transplant recipients in Thailand
Authors: Thangto Piyanut , Srisuk Oranee , Chunpeak Kanokporn , Hutchinson Ana , van Gulik Nantanit 
Published: July 2022

Background:Multidisciplinary teams play an important role in educating kidney transplant recipients and their families on ongoing self-management.Aim:To measure the knowledge of transplant recipients before and after participation in a multidisciplinary education program in Thailand.Methods:A quasi-experimental before and after study design was used to explore change in 50 recipients' knowledge following program completion. Study outcomes were analysed using descriptive statistics, differences in patient knowledge before and after programme completion were compared using paired t-tests and group differences using the Mann-Whitney U Test.Findings:There was a significant increase in total knowledge scores (baseline M=14.70, SD=2.70 vs follow-up M=18.46, SD=0.89; t =-9.46, p<0.01), and understanding of kidney transplant care (baseline M=3.74, SD=0.92 vs follow-up M=4.34, SD=0.65; t =-3.90, p<0.01) and immunosuppressive drugs (baseline M=6.10, SD=1.94 vs follow-up M=8.94, SD=0.24, t=-10.29, p<0.01). Being aged younger than, or older and equal to, 40 years was the only patient characteristic associated with statistically significant differences in patient knowledge following programme completion (t =195.00, p=0.02).Conclusion:Multidisciplinary education programmes are effective, however innovative approaches to educating older adults need further exploration.
Coupling Circularity With Carbon Negativity in Food and Agriculture Systems
Authors: Lower Lillian , Cunniffe Julia , Cheng Jay J. , Sagues William Joe 
Published: July 2022

HighlightsMany technologies required for circularity have the added benefit of carbon negativity.Precision agriculture, soil carbon sequestration, and biorefining couple circularity with carbon negativity.Stakeholders from many disciplines are needed to successfully couple circularity with carbon negativity.Abstract. Achieving a circular economy is critical for a sustainable future, particularly in sectors that currently produce resource-intensive products in a linear fashion, such as food and agriculture. At the same time, technologies that remove atmospheric CO2, often referred to as carbon dioxide removal (CDR) or carbon negativity, must be developed and deployed rapidly if we are to avoid the worst effects of climate change. Circularity and CDR are often assessed and discussed independently, even though they are highly intertwined. Innovations to food and agriculture systems are essential to achieving a circular economy and enabling rapid deployment of CDR technologies. We explore critical areas of technology that must undergo rapid innovation (upstream and downstream) to food processing and consumption, namely precision and regenerative agriculture and biorefining, respectively. If implemented at scale, these two areas of technology have the potential to couple circularity with carbon negativity in food production systems. Keywords: Biorefining, Carbon dioxide removal, Circularity, Food and agriculture systems, Precision agriculture, Soil carbon sequestration.
Occult hepatitis B virus infections and risk factors among school-going adolescent voluntary blood donors in Kwale County Kenya, January 2020–June 2021: Cross sectional study
Authors: Wahome Peter Kitemi , Kiende Polly , Nakazea Rocky Jumapili , Mwasowa Narcis Mwakidedela , Nyamu Gibson Waweru 
Published: July 2022

Background
Occult hepatitis B virus (HBV) infections remain a safety concern worldwide. The prevalence in Kenya ranges from 2.6% to 4.4% among secondary school-going voluntary blood donors. This study estimated the prevalence of occult HBV infections among school-going voluntary blood donors through donations made to Kwale Satellite Blood Transfusion Center (KSBTC).

Methods
This was a retrospective cross-sectional study on data collected by the KSBTC between January 2020 and June 2021 among secondary school-going voluntary blood donors. Data were collected in MS Excel 2013 and analyzed in Epi Info 7. Descriptive statistics were calculated and we compared donors with positive Hepatitis B surface antigen (HBsAg) to those with negative HBsAg. Crude Prevalence Odds Ratios (cPOR) at 95% confidence intervals (CI) were calculated to identify factors associated with positive HBsAg.

Results
A total of 613 records were analyzed. The mean age of the donors was 19.1 years (± 1.8 years), there were 457 males (74.5%), 502 individuals were in the age group 18–25 years (82.3%), and the mean hemoglobin level was 14.1 g/dl (±1.6 g/dl). First-time blood donors made up 84.8% of all donors (513/605) and the mean inter-donation period was 20 months (±5.8 months) for repeat donors. The sero-positivity for HBsAg was 8.8% (54/613). Age category 16–17 years with positive HBsAg were 10.2% (11/108), femaleswere10.9% (17/156), and first-time donors were 9.4% (48/513). On bivariate analyses, first-time blood donors were 1.5 times more likely to test positive for HBsAg compared to repeat donors (cPOR = 1.5, 95% CI 0.61–3.57). Females were 1.4 times more likely to test positive for HBsAg compared to male donors (cPOR = 1.4, 95% CI 0.76–2.54).

Conclusions
The majority of the voluntary blood donors were males and the majority of occult HBV infections came in the first-time blood donor group. We recommend increasing targeted recruitment of repeat donors by encouraging healthy first-timer donors to be regular donors, and suggest this population should be vaccinated against HBV infections.
Impact of age, sex and surgery type on engagement with an online patient education and support platform developed for total hip and knee replacement patients
Authors: Martin Rebecca , Clark Natalie , Baker Paul 
Published: July 2022

Background
Patients should be active participants in the management of their condition and provided with appropriate information throughout their care pathway. We piloted an online digital platform (ODP) to deliver patient education and support (PES) for patients undergoing total hip (THR) and knee replacements (TKR). The aim of this study is to analyse the demographics of patients using the ODP, determine how and when they accessed the ODP and how different sexes and age groups interacted with the ODP.

Methods
Demographics and program library logs for patients registered to the ODP between 21st September 2017 and 28th May 2020 was obtained. Associations between age, sex, type of surgery and engagement were assessed using statistical comparisons.

Results
1195 patients were registered on the ODP of which 832 (69.6%) accessed their carepacs. Patients accessed the content within their carepacs a mean of 29.1 times, spending a mean total time of 83 minutes. There was greater engagement for patients with a THR carepac (75.5%) compared to TKR (63.8%) (p<0.001). There were no differences in the proportion of patients that accessed the ODP or the total time spent on the platform dependent upon age (p = 0.34). Females accessed the platform more than males (p = 0.03). The use of a computer to access the ODP increased as age increased, whereas the use of a phone was favoured by the younger age groups (p<0.001).

Conclusion
An ODP providing information to patients regarding their surgery is effective and demonstrates high levels of patient engagement. An online resource such as this does not discriminate against age or sex in terms of accessibility and can be useful for information provision.
Cochlear implant positioning and fixation using 3D-printed patient specific surgical guides; a cadaveric study
Authors: Markodimitraki Laura M. , ten Harkel Timen C. , Bleys Ronald L. A. W. , Stegeman Inge , Thomeer Hans G. X. M. 
Published: July 2022

Hypothesis
To develop and validate the optimal design and evaluate accuracy of individualized 3D- printed surgical guides for cochlear implantation.

Background
Positioning and fixation of the cochlear implant (CI) are commonly performed free hand. Applications of 3-dimensional (3D) technology now allow us to make patient specific, bone supported surgical guides, to aid CI surgeons with precise placement and drilling out the bony well which accommodates the receiver/stimulator device of the CI.

Methods
Cone beam CT (CBCT) scans were acquired from temporal bones in 9 cadaveric heads (18 ears), followed by virtual planning of the CI position. Surgical, bone-supported drilling guides were designed to conduct a minimally invasive procedure and were 3D-printed. Fixation screws were used to keep the guide in place in predetermined bone areas. Specimens were implanted with 3 different CI models. After implantation, CBCT scans of the implanted specimens were performed. Accuracy of CI placement was assessed by comparing the 3D models of the planned and implanted CI’s by calculating the translational and rotational deviations.

Results
Median translational deviations of placement in the X- and Y-axis were within the predetermined clinically relevant deviation range (< 3 mm per axis); median translational deviation in the Z-axis was 3.41 mm. Median rotational deviations of placement for X-, Y- and Z-rotation were 5.50°, 4.58° and 3.71°, respectively.

Conclusion
This study resulted in the first 3D-printed, patient- and CI- model specific surgical guide for positioning during cochlear implantation. The next step for the development and evaluation of this surgical guide will be to evaluate the method in clinical practice.
Depression and anxiety and their associated factors among caregivers of children and adolescents with epilepsy in three selected hospitals in Amhara region, Ethiopia: A cross-sectional study
Authors: Tsehay Mekonnen , Necho Mogesie , Belete Asmare , Srahbzu Mengesha 
Published: July 2022

Background
The prevalence rates of depression and anxiety are unforeseen among primary caregivers of patients with epilepsy. Little attention is being given to the problem in Ethiopia.

Objectives
This study aimed to assess the prevalence and associated factors of depression and anxiety among caregivers of children and adolescents with epilepsy in three selected hospitals in Amhara region, Ethiopia.

Methods
Institution-based cross-sectional study was conducted in Ethiopia from January 1-30/2021. Systematic sampling technique was used. The Public Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) questionnaires were used to measure depression and anxiety respectively. Binary logistic regression model was employed independently for both depression and anxiety. Variables with P-values <0.2 were taken to multivariate analyses. Variables with P-value <0.05 in the multivariate analyses were considered to have a statistical association with depression and anxiety.

Result
A total of 383 participants involved yielding a response rate of 90.5%. The prevalence of depression and anxiety were found to be 13.7% and 10.4% respectively. Being female (Adjusted Odds Ratio (AOR) = 1.21: 95% Confidence Interval (CI): 1.00, 3.82), being unmarried (AOR = 1.31; 95%CI: 0.32, 5.023), having history of chronic medical illness (AOR = 1.46; 95%CI: 1.07, 1.98), current seizure attack (AOR = 4.19; 95%CI: 1.36, 12.97), duration of care 6-11years (AOR = 1.80; 95%CI: 1.11, 7.58), duration of care > 11years (AOR = 6.90; 95%CI: 1.56, 30.49), moderate social support (AOR = 0.37; 95%CI: 0.13, 0.81), strong social support (AOR = 0.61; 95%CI: 0.22, 1.67) and currently use substance (AOR = 2.01;95%CI: 1.63, 6.46) were factors associated with depression. On the other hand, being unmarried (AOR = 1.47; 95%CI: 1.12, 1.93), current seizure attack (AOR = 1.81 with 95% CI = 1.28–2.54), able to read and write (AOR = 0.33; 95%CI: 0.14, 0.77), completed primary and secondary education (AOR = 0.54; 95%CI: 0.39, 0.76), current substance use (AOR = 1.466; 95%CI: 1.12, 1.93), being parent (AOR = 2.55; 95%CI: 1.31, 4.96), rural (AOR = 3.75; 95%CI: 1.40, 10.04) and grand mal type (AOR = 2.21; 95%CI: 1.68, 2.91) were factors associated with anxiety.

Conclusions
In our study, approximately one in fifteen and more than one in ten caregivers had depression and anxiety respectively. The result of this study suggested that healthcare providers need to pay more attention to the psychological well-being of all caregivers of children and adolescents with epilepsy.
Investigating the associations between intimate partner violence and nutritional status of women in Zimbabwe
Authors: Mukamana Jeanette Iman’ishimwe , Machakanja Pamela , Zeeb Hajo , Yaya Sanni , Adjei Nicholas Kofi 
Published: July 2022

Background
Intimate partner violence (IPV) against women and poor nutritional status are growing health problems in low and middle-income countries (LMICs). Moreover, violence against women has been shown to be associated with poor nutrition. This study investigated the relationship between IPV and nutritional status (i.e., underweight, overweight, and obesity) among women of reproductive age (15–49 years) in Zimbabwe.

Methods
Pooled data from the 2005/2006, 2010/2011, and 2015 Zimbabwe Demographic Health Surveys (ZDHS) on 13,008 married/cohabiting women were analysed. Multinomial logistic regression models were used to examine the associations between the various forms of IPV and the nutritional status of women. We further estimated the prevalence of BMI ≥ 25.0 kg/m2 (overweight and obesity) by intimate partner violence type.

Results
The mean BMI of women was 24.3 kg/m2, more than one-fifth (24%) were overweight and about 12% were obese. Forty-three percent (43%) of women reported to have ever experienced at least one form of intimate partner violence. More than one-third (35%) of women who reported to have ever experienced at least one form of intimate partner violence had a BMI ≥ 25.0 kg/m2 (p< 0.01). Relative to normal weight, women who had ever experienced at least one form of IPV (i.e., physical, emotional, or sexual) were more likely to be obese (aOR = 2.59; 95% CI = 1.05–6.39). Women’s exposure to any form of intimate partner violence was not significantly associated with the likelihood of being underweight or overweight relative to normal weight.

Conclusions
The study findings show that women of reproductive age in Zimbabwe are at high risk of both IPV and excess weight. Moreover, we found a positive relationship between exposure to at least one form IPV and obesity. Public health interventions that target the well-being, empowerment and development of women are needed to address the complex issue of IPV and adverse health outcomes, including obesity.
Passive mechanical properties of the left ventricular myocardium and extracellular matrix in hearts with chronic volume overload from mitral regurgitation
Authors: Corporan Daniella , Saadeh Maher , Yoldas Alessandra , Mudigonda Jahnavi , Lane Brooks Alexander , Padala Muralidhar 
Published: July 2022

AbstractCardiac volume overload from mitral regurgitation (MR) is a trigger for left ventricular dilatation, remodeling, and ultimate failure. While the functional and structural adaptations to this overload are known, the adaptation of myocardial mechanical properties remains unknown. Using a rodent model of MR, in this study, we discern changes in the passive material properties of the intact and decellularized myocardium. Eighty Sprague‐Dawley rats (350–400 g) were assigned to two groups: (1) MR (n = 40) and (2) control (n = 40). MR was induced in the beating heart by perforating the mitral leaflet with a 23G needle, and rats were terminated at 2, 10, 20, or 40 weeks (n = 10/time‐point). Echocardiography was performed at baseline and termination, and explanted hearts were used for equibiaxial mechanical testing of the intact myocardium and after decellularization. Two weeks after inducing severe MR, the myocardium was more extensible compared to control, however, stiffness and extensibility of the extracellular matrix did not differ from control at this timepoint. By 20 weeks, the myocardium was stiffer with a higher elastic modulus of 1920 ± 246 kPa, and a parallel rise in extracellular matrix stiffness. Despite some matrix stiffening, it only contributed to 31% and 36% of the elastic modulus of the intact tissue in the circumferential and longitudinal directions. At 40 weeks, similar trends of increasing stiffness were observed, but the contribution of extracellular matrix remained relatively low. Chronic MR induces ventricular myocardial stiffening, which seems to be driven by the myocyte compartment of the muscle, and not the extracellular matrix.
Appropriated protection time and region for Qinghai–Tibet Plateau grassland
Authors: Qian Shuan , Pan Feifei , Wu Menxin , Sun Yinglong 
Published: July 2022

Abstract
Grassland accounts for 67% of the land area in Qinghai–Tibet Plateau (QTP) to sensitive to climate. This article carried out extensive temporal–spatial variations of grassland water deficit/surplus (GWDS) and net primary productivity (NPP) of QTP grassland using meteorological data of 1981–2018. The results indicate that precipitation’s temporal variations are not related to potential evapotranspiration (PET). The maximum monthly precipitation occurs in July, while the maximum monthly PET appears in June. Precipitation is the second highest in spring when PET is the highest. The water deficit (PET-precipitation) from March to June takes up 51.4% of the total year. Therefore, droughts are more likely to happen in spring and June. This is the most important period for grassland protection. Water deficit is higher in the central and west and the highest in the northwest of QTP grasslands. This indicates the place where the droughts are more likely to occur. The grassland’s annual NPP is high in the southeastern part of QTP and low in the west. This shows the central and western parts of QTP grassland should receive more attention. The specific time and region obtained in this study are important for environmental protection policy-making and reducing grassland degradation in QTP.
Convergence analysis of iteratively regularized Gauss–Newton method with frozen derivative in Banach spaces
Authors: Mittal Gaurav , Giri Ankik Kumar 
Published: July 2022

Abstract
In this paper, we consider the iteratively regularized Gauss–Newton method with frozen derivative and formulate its convergence rates in the settings of Banach spaces. The convergence rates of iteratively regularized Gauss–Newton method with frozen derivative are well studied via generalized source conditions. We utilize the recently developed concept of conditional stability of the inverse mapping to derive the convergence rates. Also, in order to show the practicality of this paper, we show that our results are applicable on an ill-posed inverse problem. Finally, we compare the convergence rates derived in this paper with the existing convergence rates in the literature.
An estimation of HOMO–LUMO gap for a class of molecular graphs
Authors: Hameed Saira , Alamer Ahmed , Javaid Muhammad , Ahmad Uzma 
Published: July 2022

Abstract
For any simple connected graph G of order n, having eigen spectrum μ
1 ≥ μ
2 ≥ ⋯ ≥ μ

n
with middle eigenvalues μ
H and μ
L, where H = ⌊(n + 1)/2⌋ and L = ⌈(n + 1)/2⌉, the HOMO–LUMO gap is defined as as ΔG = μ
H = μ
L. In this article, a simple upper bound for the HOMO–LUMO gap corresponding to a special class of connected bipartite graphs is estimated. As an application, the upper bounds for the HOMO–LUMO gap of certain classes of nanotubes and nanotori are estimated.
miR‐124‐dependent tagging of synapses by synaptopodin enables input‐specific homeostatic plasticity
Authors: Dubes Sandra , Soula Anaïs , Benquet Sébastien , Tessier Béatrice , Poujol Christel , Favereaux Alexandre , Thoumine Olivier , Letellier Mathieu 
Published: July 2022

AbstractHomeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on a neuron respond uniformly to the same perturbation remains unclear. Moreover, the molecular determinants that underlie synapse‐specific homeostatic synaptic plasticity are unknown. Here, we report a synaptic tagging mechanism in which the ability of individual synapses to increase their strength in response to activity deprivation depends on the local expression of the spine‐apparatus protein synaptopodin under the regulation of miR‐124. Using genetic manipulations to alter synaptopodin expression or regulation by miR‐124, we show that synaptopodin behaves as a “postsynaptic tag” whose translation is derepressed in a subpopulation of synapses and allows for nonuniform homeostatic strengthening and synaptic AMPA receptor stabilization. By genetically silencing individual connections in pairs of neurons, we demonstrate that this process operates in an input‐specific manner. Overall, our study shifts the current view that homeostatic synaptic plasticity affects all synapses uniformly to a more complex paradigm where the ability of individual synapses to undergo homeostatic changes depends on their own functional and biochemical state.
All that Glitters is not Cholecystitis. A Rare Presentation of Acute Pericarditis Mimicking Cholecystitis and Review of the Literature
Authors: Garmpi Anna , Damaskos Christos , Garmpis Nikolaos , Georgakopoulou Vasiliki Epameinondas , Kaminiotis Vaios Vasileios , Diamantis Evangelos , Patsouras Alexandros , Syllaios Athanasios , Dimitroulis Dimitrios 
Published: July 2022

Acute pericarditis is the most common inflammatory disorder of the pericardium, responsible for approximately 5% of visits to the emergency departments, concerning chest pain without myocardial infarction. We report a case of a 41-year-old man who presented to our hospital, complaining about retrosternal and epigastrium pain. The transthoracic echocardiogram showed pericardial effusion while the electrocardiogram and laboratory findings revealed acute pericarditis. An abdominal ultrasound revealed gallbladder edema. The pericardial effusion was treated with pericardial catheter insertion, diuretics, and nonsteroidal anti-inflammatory drugs. This case shows that acute pericarditis can be clinically presented with many ways, one of them being gallbladder edema. Furthermore, in this case-based review we present all cases of simultaneous appearance of pericarditis and acalculous cholecystitis or gallbladder edema.
Full-semester and time-compressed fluency disorders course: an evaluation of student perceptions of competence, satisfaction, and workload
Authors: DeVeney Shari L. , Teten Amy F. , Friehe Mary J. 
Published: July 2022

This article addresses the effectiveness of a time-compressed four-week course format compared to a full-semester 16-week format for a graduate-level course. Participants were 78 students enrolled in a speech-language pathology course, fluency disorders. No significant differences were noted for student competency self-perceptions. However, time-compressed students reported significantly higher levels of course satisfaction and workload difficulty.