bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calibration scheme for space-borne full-disk vector magnetograph under the influence of orbiter velocity
Authors: Hu Ziyao , Ji Kaifan , Chen Jie , Deng Yuanyong , Su Jiangtao , Bai Xianyong , Liu Suo , Guo Jingjing , Liu Jiajia , Wintoft Peter 
Published: July 2022

Context. The Full-disk Vector MagnetoGraph (FMG) is one of the three payloads on the Advanced Space-based Solar Observatory (ASO-S). The FMG is set to observe the full disk vector magnetic field at a single wavelength point. The magnetograph in orbit will encounter the wavelength shift problem caused by the Doppler effect in the magnetic field, which mainly comes from the Sun’s rotation velocity and the satellite–sun relative velocity.
Aims. We look to use neural networks for single-wavelength calibration to solve the wavelength shift problem.
Methods. We used the existing data from the Helioseismic and Magnetic Imager (HMI) on the Solar Dynamics Observatory (SDO). To simulate plausible single-wavelength observations, we used the Stokes polarization image from the HMI at a single wavelength point. We also input the satellite orbital velocity given by the HMI data file and the solar rotation velocity to the network. We developed a set of data preprocessing methods before entering the network and we trained the network to get the calibration model.
Results. By analyzing and comparing the prediction of the neural network with the target magnetogram, we believe that our network model has learned a single-wavelength full-disk calibration model. The mean absolute error (MAE) of the longitudinal field and the transverse field of the full disk are 3.68 G and 28.08 G, respectively. The MAE error of the azimuth angle of pixels above 300 G is 12.29°.
Atraumatische Ruptur der Extensor Hallucis Longus Sehne
Authors: Peters Jan , Köhler Hans-Christian , Müller-Meinhard Doris , Gutcke Andre , Rüttermann Mike 
Published: July 2022

ZusammenfassungDie atraumatische Ruptur der Sehne des Extensor-hallucis-longus ist ein sehr
seltenes Krankheitsbild. Chronische Überlastung durch Kontaktsportarten,
anatomische Besonderheiten am Knochen, vorangegangene Operationen sowie
Medikamenteninjektionen im Bereich der Sehne wurden bereits als Ursache
berichtet. Wir berichten über einen jungen Patienten, der sich ohne
erkennbaren Grund mit einem akuten Funktionsverlust seiner
Extensor-hallucis-longus-Sehne in unserer Sprechstunde vorstellte.
Morbidly Adherent Placenta in the First Trimester with Consecutive
Hysterectomy
Authors: Habek Dubravko , Karadjole Vesna Sokol , Knežević Fabijan , Marton Ingrid , Ivanišević Marina 
Published: July 2022

AbstractBackground Morbidly adherent placenta (MAP) represents a risk factor for a
maternal adverse outcome and its incidence continues to rise following the
increasing rate of caesarean deliveries. The detection of a pathology of
placental adherence in the first trimester is challenging. Transvaginal
ultrasound represents (TVUS) a reliable tool for accurate and timely diagnosis.
Case We report on a case of MAP in a pregnant woman at 10 weeks of gestation
with two prior caesarean deliveries. She presented with abdominal pain and
hematometra. The first trimester diagnosis was made with TVUS and confirmed with
magnetic resonance imaging. The patient required an urgent hysterectomy.
Conclusion Antenatal care in the first trimester in women with a previous
cesarean delivery should include a detailed examination of the placenta with
TVUS.
Is There a Role for Laboratory Parameters in Predicting Coronary
Artery Involvement in Kawasaki Disease?
Authors: Yalcinkaya Rumeysa , Öz Fatma Nur , Durmuş Sevgi Yaşar , Fettah Ali , Kaman Ayşe , Teke Türkan Aydın , Örün Utku Arman , Tanır Gönül 
Published: July 2022

Abstract
Background Kawasaki disease (KD) may cause cardiac and coronary
complications. Since definite markers to accurately predict coronary involvement
is not present, we aimed to analyze the role of hematological indices
[neutrophil-to lymphocyte ratio (NLR), platelet-to lymphocyte ratio (PLR),
lymphocyte-to monocyte ratio (LMR), and mean platelet volume (MPV)-to lymphocyte
ratio (MPVLR)], prognostic nutritional index (PNI) and systemic
immune-inflammation index (SII) in predicting coronary involvement of KD.
Patients The medical records of 134 KD patients admitted between January
2008 and December 2019 were investigated. Also, 268 age-matched healthy controls
(HCs) were included in the study.
Methods KD patients were divided into two groups: KD with coronary artery
lesions (KD-CALs) and KD without CALs. Logistic regression analysis was
performed to determine parameters that may predict coronary involvement in
children with KD.
Results Among KD patients, 39 (29.1%) had CALs. When compared with
HCs, the median levels of WBC, neutrophils, monocytes, eosinophils, platelets,
MPV and, the values of NLR, PLR, MPVLR, SII were significantly higher; whereas
lymphocyte count, PNI, platelet distribution width (PDW), LMR were markedly
lower in the KD group (p˂0.001 for all, except for p=0.010 for
eosinophil count). The CALs group's SII, PLR, and PNI values were
significantly lower than those without (p=0.030, p=0.032, and p
˂0.001; respectively). Multivariable regression analysis revealed that PNI, SII,
and gender (male) were associated with CALs in KD.
Conclusion Our analysis revealed that male sex, lower PNI, and lower SII
levels were independently associated with CALs in children with KD.
Wasser und Gesundheit
Authors: Rampp Thomas 
Published: July 2022

SummarySeit Jahrhunderten kommen Wasseranwendungen zur Steigerung von Gesundheit und Wohlbefinden zum Einsatz. Studien belegen die Wirksamkeit der Wassertherapie nach Kneipp bei Indikationen wie chronisch-venöser Insuffizienz, Hypertonie, leichter Herzinsuffizienz, menopausalen Beschwerden und Schlafstörungen. Bei äußerlichen Anwendungen spielen Wärme oder Kälte eine wichtige Rolle. So kann Eisbaden zum Beispiel die Stressresistenz, die emotionale Stabilität sowie das Herz-Kreislauf-System stärken. Wärmebäder besitzen eine entspannende und stressregulierende Wirkung. Innerlich angewandt hat eine hohe Wasseraufnahme ebenfalls viele positive Effekte auf den Körper.
Moore, Mythen, Medizin
Authors: Tanneberger Franziska , Körner Nina 
Published: July 2022

SummaryMoorbäder und die Gedichte von Droste-Hülshoff sind oft strapaziert im Zusammenhang mit Moor. Viel wichtiger für Moore und für die Existenz und Gesundheit des Menschen ist jedoch ihre Bedeutung für den Klimaschutz. Moore sind nicht unheimlich, sondern unheimlich wichtig, und zwar für alle. Medizinische Produkte aus dem Moor erscheinen dabei fast als „Kollateralnutzen“.
Transition-Metal-Catalyzed Regioselective C–H Borylation of ­Pyridines
Authors: Xu Xin , Sun Qianlin , Luo Yuncong 
Published: July 2022

AbstractThe C–H borylation strategy has spurred intense research endeavors due to the high atom- and step-economy it represents and because of the broad range of utilities of the resulting organoboranes. Nevertheless, this powerful transformation has had limited substrate scope and poor regioselectivity when it was applied to Lewis basic substrates (e.g., azines). The basic functionalities in substrates can coordinate to the metal centers, hindering the formation of products. Herein, we provide a brief overview of recent advances in transition-metal-­catalyzed regioselective C–H borylation of pyridines. Attention is paid to the latest contributions, which have demonstrated remarkable ­regioselectivity.1	Introduction2	para-Selective C−H Borylation3	meta-Selective C−H Borylation4	ortho-Selective C−H Borylation5	Summary
Advances in the Iron-Catalyzed Direct Functionalizations of ­Heterocycles
Authors: Punji Benudhar , Pradhan Chandini 
Published: July 2022

AbstractDirect functionalization of heterocycles is an advanced strategy for diversifying privileged and biorelevant heterocycle-containing molecules. Particularly, use of the most abundant transition metal, iron, as a catalyst makes this process highly cost-effective and sustainable. Recently, some progress has been realized towards the direct functionalization of heterocycles under iron catalysis. Herein, we present the developments in the C–H bond functionalizations and related reactions of various heterocycles by abundant iron salts. This Synpacts is categorized into different sections based on heterocycles being functionalized, and each section is discussed based on the type of reaction catalyzed by iron.1	Introduction2	Functionalization of Indoles2.1	Alkylation2.2	Alkenylation2.3	Other Reactions3	Oxindoles and Isatins3.1	C–C Bond Formation3.2	C–Heteroatom Bond Formation4	Pyridines and Furans5	Functionalization of Azoles6	Summary and Outlook
Solvent/Ligand-Controlled Switchable C3 or C7 C–H Arylations of 1-Methyl-4-nitro-1H-indazole
Authors: El Kazzouli Saïd , Boujdi Khalid , El Brahmi Nabil , Collet Sylvain , Dubreuil Didier , Mathé-Allainmat Monique , Akssira Mohamed , Guillaumet Gérald , Lebreton Jacques 
Published: July 2022

AbstractA new solvent/ligand-controlled switchable C–H arylation of 1-methyl-4-nitro-1H-indazole catalyzed by Pd(OAc)2 was achieved. A bidentate ligand in DMA promoted the activation at C7 position, while a phosphine ligand in H2O oriented the arylation at C3 position. The C3 and C7 arylation products were obtained in moderate to good yields and with high regioselectivity.
Monitoring of Catalyst-Free Microwave-Assisted MCR-Type Synthesis of 2-Amino-3-cyano-4H-chromene Derivatives Using Raman Spectrometry
Authors: Besson Thierry , Hebert Olivier , Dubouilh-Benard Carole , Campos Joana F. , Berteina-Raboin Sabine , Fruit Corinne 
Published: July 2022

AbstractIn order to prepare an array of β-cyanoenamine derivatives as potential precursors of heterocyclic systems with pharmaceutical interest, the synthesis of fifteen polyfunctionalized 4H-chromenes was realized via a microwave-assisted and catalyst-free three-component reaction. Microwave-heated reactions were monitored by Raman spectroscopy, enabling a fast and efficient setting of the process parameters. This study confirms that this monitoring tool may have some limitations linked to homogeneity of reaction medium. This work also investigates the use of some bio-sourced and sustainable solvents currently studied in many works. Ethanol remains the most suitable for this synthesis.
A Lignan from Alnus japonica Activates Myogenesis and Alleviates Dexamethasone-induced Myotube Atrophy
Authors: Lee Hyejin , Jeong Ji Hye , Hwang Seung Hwan , Yeon Sung Hum , Ryu Jae-Ha 
Published: July 2022

AbstractTo find inhibitors against skeletal muscle loss, we isolated a lignan compound ((−)-(2R,3R-1,4-O-diferuloylsecoisolarciresinol, DFS) from the stem of Alnus japonica.
C2C12 myoblasts were treated with DFS during differentiation. To induce an in vitro atrophic condition, differentiated myotubes were treated with dexamethasone (a synthetic
glucocorticoid). DFS (10 nM) increased expression levels of myogenic factors and the number of multi-nucleated myotubes expressing myosin heavy chain (MHC). The myogenic potential of DFS
could be attributed to p38 MAPK activation. DFS also protected against dexamethasone-induced damage, showing increased expression of MHC and mammalian target of rapamycin (mTOR), a major
anabolic factor. Under atrophic condition, the anti-myopathy effect of DFS was associated with inactivation of NF-κB signaling pathway and the subsequent suppression of muscle
degradative E3 ligases and myostatin. DFS treatment also restored fast muscle fiber (type II a, II b, and II x), known to be susceptible to dexamethasone. These results indicate that DFS
isolated from A. japonica can stimulate myogenesis via p38 MAPK activation and alleviate muscle atrophy by modulating the expression of genes associated with muscle protein
anabolism/catabolism. Thus, we propose that DFS can be used as a pharmacological and nutraceutical agent for increasing muscle strength or protecting muscle loss.
A Flavonoid-rich Zuccagnia punctata Extract Prevents High Fat Diet-induced Normal Weight Obesity in a Rabbit Model
Authors: Valoy Agostina , Alarcón Gabriela , Roco Julieta , Zampini Catiana , Isla María Ines , Jerez Susana 
Published: July 2022

AbstractOral administration of rich in flavonoids hydroalcoholic extract from Zuccagnia punctata (ZpE) improves lipid profile and prevents vascular dysfunction in hypercholesterolemic
rabbits. This study aimed to evaluate the ability of ZpE to prevent metabolic and vascular alterations induced by high fat diet (HFD) on a metabolically obese and normal weight rabbit model.
The major components of ZpE were analyzed by HPLC method. Rabbits were separated into six groups: 1-fed on standard chow (CD); 2-fed on HFD; 3, 4, 5- fed on HFD and orally administrated
2.5 mg, 5 mg or 10 mg GAE/day of ZpE, respectively (ZpE- HFD); 6- fed on HFD and orally administered 30 mg orlistat/day (Or-HFD). All diets were administrated by 6 weeks. The major compounds
of ZpE identified were chalcones: 2′,4′-dihydroxy-3′-methoxychalcone and 2′,4′-dihydroxychalcone. Oral treatment with ZpE 5 mg GAE/day as well as orlistat prevented the HFD-induced increase
of triglycerides, fasting glucose, intraperitoneal glucose test, white cells, and TyG index. Acetylcholine relaxation was reduced in arteries from HFD group and oral administration of ZpE
reached this response to CD values. Contractile response to angiotensin II was lower in arteries from rabbits fed on HFD treated with ZpE 5 and 10 mg GAE/day than those of untreated rabbits.
Moreover, ZpE could inhibit the activity of pancreatic lipase in vitro and in vivo. In conclusion the ZpE may prevent normal weight obesity by inhibiting the pancreatic lipase.
Thus, the use of ZpE as a natural product in the prevention of metabolic syndrome and endothelial dysfunction is very promising.
Tricuspid Valve Surgery in Patients Receiving Left Ventricular Assist Devices
Authors: Tie Hongtao , Shi Rui , Welp Henryk , Martens Sven , Li Zhenhan , Sindermann Jürgen R. , Martens Sabrina 
Published: July 2022

Abstract
Background Tricuspid regurgitation (TR) is common and related to poor prognosis in patients after left ventricular assist device (LVAD) implantation. The concomitant tricuspid valve surgery (TVS) at the time of LVAD implantation on short and long-term outcomes are controversial in current evidence.
Methods This is a single-center, observational, retrospective study. We enrolled patients with moderate-to-severe TR who received LVAD implantations from 2009 to 2020. Postoperative right ventricular failure (RVF), right ventricular assist device (RVAD) use, hospital mortality, new-onset renal replacement therapy (RRT), and acute kidney injury (AKI) were evaluated retrospectively.
Results Sixty-eight patients were included, 36 with and 32 without concomitant TVS. Baseline characteristics did not differ between the two groups. Patients receiving TVS had significantly increased incidences of postoperative RVF (52.8 vs. 25.0%, p = 0.019), RVAD implantation (41.7 vs. 18.8%, p = 0.041), and new-onset RRT (22.2 vs. 0%, p = 0.004). No difference in the incidence of AKI and hospital mortality was detected. Besides, these associations remained consistent in patients who underwent LVAD implantation via median sternotomy. During a median follow-up of 2.76 years, Kaplan–Meier analysis and competing-risk analysis showed that TVS was not associated with better overall survival in patients after LVAD implantation compared with the no-TVS group.
Conclusion Our study suggests that concomitant TVS failed to show benefits in patients receiving LVAD implantation. Even worse, concomitant TVS is associated with significantly increased incidences of RVF, RVAD use, and new-onset of RRT. Considering the small sample size and short follow-up, these findings warrant further study.
Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis
Authors: Hendrijantini Nike , Suisan Yonatan Christian , Megantara Rizko Wira Artha , Tumali Bambang Agustono Satmoko , Kuntjoro Mefina , Ari Muhammad Dimas Aditya , Sitalaksmi Ratri Maya , Hong Guang 
Published: July 2022

Abstract
Objectives This study aimed to determine some of bone molecular expressions and its possible bone remodeling pathway between diabetes mellitus (DM) and osteoporosis model in the mandibular bone of Wistar rats.
Materials and Methods Twenty-seven female Wistar rats were divided randomly into control and treatment groups. Treatment groups were injected with streptozotocin intraperitoneally to induce DM (P1) and underwent bilateral ovariectomy to generate osteoporosis (P2). All groups were terminated after 12 weeks. Immunohistochemical and hematoxylin–eosin staining were performed to determine the expression of Runt-related transcription factor 2 (RUNX2), Osterix, vascular endothelial growth factor (VEGF), receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and observed the osteoblast and osteoclast. Statistical analysis was performed using one-way analysis of variance.
Results The lowest mean of RUNX2 and VEGF expression was found in the P2 group. The lowest mean of Osterix expression was found in the P1 group. Both P1 and P2 groups of osteoblast/osteoclast ratio were decreased. There were no significant differences in the expression of TRAP between all groups; however, increased expression of RANKL/OPG ratio was only found in the P2 group.
Conclusion DM and osteoporosis induce changes in the bone remodeling pathway which are represented by a decrease in osteoblast biomarkers and an increase in osteoclast biomarkers.
Immunohistochemical Evaluation of the Pathological Effects of Diabetes Mellitus on the Major Salivary Glands of Albino Rats
Authors: Alqahtani Mashael Saeed , Hassan Sherif Sayed 
Published: July 2022

Abstract
Objectives Diabetes mellitus is a notorious chronic disease characterized by hyperglycemia. Our study aimed to determine the expression of cytokeratin 17 (CK17) in all major salivary glands of diabetic albino rats to provide more information about the pathological effects of DM on the intracellular structures of the gland parenchyma.
Materials and Methods Twenty male adult albino rats were utilized in the experiment and divided into two equal groups, group 1 (control rats) and group 2 (diabetic rats). The animals were sacrificed 45 days after diabetes induction. The major salivary gland complex of all groups was dissected and prepared for evaluation by histological and immunohistochemical expression of CK17.
Results Histological results prove that the salivary gland parenchyma of diabetic group undergo gland atrophy characterized with the presence of degenerated acini, dilated duct system, and presence of duct-like structure with predominance of fibrous tissue compartment and discrete fat cells. Immunohistochemical expression of CK17 of major salivary gland of control group revealed negative to diffuse mild expression in all duct cells and some serous acinar cells, whereas mucous acini were negatively stained. On the other hand, major salivary gland parenchyma of diabetic group demonstrated mild to strong expression of duct cells more concentrated at their apical part with moderate to strong expression of some serous acini of diffuse type, whereas mucous acini of both submandibular gland and sublingual gland were negatively stained.
Conclusion The severity and prevalence of CK 17 in our results are predictive of the pathological influence of the DM that interferes with saliva production and/or secretion leading to dry mouth. The results also showed clear changes in the cytokeratin expression of diabetic sublingual salivary gland, although it had little effect in the routine histological study with hematoxylin and eosin, confirming that routine studies are not sufficient to form a definitive opinion.
Evaluation of Skeletal Changes after Mandibular Setback Surgery Using the NM-Low Z Plasty Technique in Skeletal Class III Patients
Authors: Imampai Sarunpong , Patchanee Siripatra , Klaisiri Awiruth , Chaiprakit Narissaporn 
Published: July 2022

Abstract
Objective The study's objective was to evaluate skeletal changes in 38 skeletal class III patients following mandibular setback surgery using NM-Low Z plasty.
Materials and Methods Thirty-eight skeletal class III patients (ANB angle lower than 0) who underwent the NM-Low Z plasty technique for surgical mandibular setback procedure at Thammasat University Hospital between January 2017 and March 2020 were included in the study: 29 patients had two jaw surgeries, and 9 patients had one jaw surgery. An additional 14 patients had genioplasty. Three lateral cephalograms were traced and digitized with Dolphin Imaging software: T0, T1, and T2. The distance between the B-point and the SN7 perpendicular line defined immediate changes after surgery (T1-T0) and stability after surgery (T2-T1). The reliability test included 6 cephalograms retraced after 2-week interval. At point B, the principal result was horizontal movement forward.
Statistical Analysis The analysis used paired t-tests.
Results The mean mandibular setback was 9.78 mm, and the mean skeletal relapse was 2.61 mm, or 26.69%. Statistical analysis showed postoperative differences (p < 0.05). Vertical measurement in B-SN7 reduced immediately and postoperatively.
Conclusion Postoperatively, the mandible relapsed significantly forward and upward. Rotational relapse is a concern with NM-Low Z plasty in hypo-/normodivergent patients.
Role of Serum Ferritin and PRISM-III in Predicting Mortality in Children with Acute Encephalitis Syndrome in Northern India
Authors: Toteja Nisha , Sasidharan Rohit , Kumar Sachin , Zaman Kamran , Singh Vijay Kumar , Jaiswal Vineet , Srivastava Kanchan , Tiwari Harish , Mittal Mahima 
Published: July 2022

AbstractThe aim of this study was to evaluate the role of serum ferritin (SF) and PRISM-III (Pediatric Risk of Mortality) score in predicting mortality in critically ill children aged 6 months to 15 years diagnosed with acute encephalitis syndrome (AES) admitted to the pediatric intensive care unit (PICU). This prospective observational study was conducted in the PICU of a tertiary teaching hospital in Northern India between July 2018 and June 2019. The primary outcome was to determine the association of admission SF levels with mortality. Secondary outcomes included estimating the prevalence of hyperferritinemia and comparing SF with PRISM-III scores in predicting mortality. Etiology could be established in 85.5% (n = 219) of the 256 children enrolled. Scrub typhus accounted for nearly two-thirds of the cases (60.5%), while dengue and Japanese encephalitis were the next common diagnoses. The median [interquartile range] SF at admission was significantly higher among the nonsurvivors than survivors: 514 [260–1,857] and 318 [189–699] µg/L, respectively (p = 0.029). SF and PRISM-III independently predicted mortality in AES. However, both had poor discriminatory power with area under receiver operating curve (95% confidence interval) of 0.61 (0.51–0.72) and 0.67 (0.56–0.77), respectively. Elevated SF and higher PRISM-III scores independently predicted mortality in children admitted to PICU with AES.