bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet-Derived TGF (Transforming Growth Factor)-β1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation
Authors: Zhu Ying , Shu Dan , Gong Xue , Lu Meng , Feng Qinyu , Zeng Xiang-Bin , Zhang Han , Gao Jiahui , Guo Ya-Wei , Liu Luman , Ma Rong , Zhu Liping , Hu Qinghua , Ming Zhang-Yin 
Published: March 2022

Background:
Metabolic reprogramming is a hallmark of pulmonary arterial hypertension. Platelet activation has been implicated in pulmonary arterial hypertension (PAH), whereas the role of platelet in the pathogenesis of PAH remains unclear.

Methods:
First, we explored the platelet function of semaxanib‚ a inhibitor of VEGF receptor (SU5416)/hypoxia mice and monocrotaline-injected rats PAH model. Then we investigated pulmonary arterial smooth muscle cell aerobic glycolysis after being treated with platelet supernatant. TGF (transforming growth factor)-βRI, pyruvate kinase muscle 2, and other antagonists were applied to identify the underlying mechanism. In addition, platelet-specific deletion TGF-β1 mice were exposed to chronic hypoxia and SU5416. Cardiopulmonary hemodynamics, vascular remodeling, and aerobic glycolysis of pulmonary arterial smooth muscle cell were determined.

Results:

Here, we demonstrate that platelet-released TGF-β1 enhances the aerobic glycolysis of pulmonary arterial smooth muscle cells after platelet activation via increasing pyruvate kinase muscle 2 expression. Mechanistically, platelet-derived TGF-β1 regulate spyruvate kinase muscle 2 expression through mTOR (mammalian target of rapamycin)/c-Myc/PTBP-1(polypyrimidine tract binding protein 1)/hnRNPA-1(heterogeneous nuclear ribonucleoprotein A1) pathway. Platelet TGF-β1 deficiency mice are significantly protected from SU5416 plus chronic hypoxia–induced PAH, including attenuated increases in right ventricular systolic pressure and less pulmonary vascular remodeling. Also, in

Pf4cre
+
Tgfb1
fl/fl

mice, pulmonary arterial smooth muscle cells showed lower glycolysis capacity and their pyruvate kinase muscle 2 expression decreased.

Conclusions:
Our data demonstrate that TGF-β1 released by platelet contributes to the pathogenesis of PAH and further highlights the role of platelet in PAH.
Formulation and Emulation of Quantum-Inspired Dynamical Systems With Classical Analog Circuits
Authors: Cressman A. J. , Wattanapanitch W. , Chuang I. , Sarpeshkar R. 
Published: March 2022

Abstract
Quantum dynamical systems are capable of powerful computation but are hard to emulate on digital computers. We show that four novel analog circuit parts can emulate the phase-coherent unitary dynamics of such systems. These four parts are: a Planck capacitance analogous to a neuronal membrane capacitance; a quantum admittance element, together with the Planck capacitance, analogous to a neuronal quadrature oscillator; a quantum transadmittance element analogous to a complex neuronal synapse; and a quantum transadmittance mixer element analogous to a complex neuronal synapse with resonant modulation. These parts may be emulated classically, with paired real-value voltages on paired Planck capacitances corresponding to the real and imaginary portions of a probability amplitude; and appropriate paired real-value currents onto these Planck capacitances corresponding to diagonal (admittance), off-diagonal (transadmittance), or controlled off-diagonal (transadmittance mixer) Hamiltonian energy terms. The superposition of 2n simultaneously phase-coherent and symmetric probability-voltage amplitudes with O(n) of these parts, in a tensor-product architecture enables analog emulation of the quantum Fourier transform (QFT). Implementation of our circuits on an analog integrated circuit in a 0.18 μm process yield experimental results consistent with mathematical theory and computer simulations for emulations of NMR, Josephson junction, and QFT dynamics. Our results suggest that linear oscillatory neuronal networks with pairs of complex subthreshold/nonspiking sine and cosine neurons that are coupled together via complex synapses to other such complex neurons can architect quantum-inspired computation with classical analog circuits. Thus, an analog-circuit mapping between quantum and neural computation, both of which exploit analog computation for powerful operation, can enable future synergies between these fields.
Understanding Dynamics of Nonlinear Representation Learning and Its Application
Authors: Kawaguchi Kenji , Zhang Linjun , Deng Zhun 
Published: March 2022

Abstract
Representations of the world environment play a crucial role in artificial intelligence. It is often inefficient to conduct reasoning and inference directly in the space of raw sensory representations, such as pixel values of images. Representation learning allows us to automatically discover suitable representations from raw sensory data. For example, given raw sensory data, a deep neural network learns nonlinear representations at its hidden layers, which are subsequently used for classification (or regression) at its output layer. This happens implicitly during training through minimizing a supervised or unsupervised loss. In this letter, we study the dynamics of such implicit nonlinear representation learning. We identify a pair of a new assumption and a novel condition, called the on-model structure assumption and the data architecture alignment condition. Under the on-model structure assumption, the data architecture alignment condition is shown to be sufficient for the global convergence and necessary for global optimality. Moreover, our theory explains how and when increasing network size does and does not improve the training behaviors in the practical regime. Our results provide practical guidance for designing a model structure; for example, the on-model structure assumption can be used as a justification for using a particular model structure instead of others. As an application, we then derive a new training framework, which satisfies the data architecture alignment condition without assuming it by automatically modifying any given training algorithm dependent on data and architecture. Given a standard training algorithm, the framework running its modified version is empirically shown to maintain competitive (practical) test performances while providing global convergence guarantees for deep residual neural networks with convolutions, skip connections, and batch normalization with standard benchmark data sets, including MNIST, CIFAR-10, CIFAR-100, Semeion, KMNIST, and SVHN.
Cold Pools Observed during EUREC4A: Detection and Characterization from Atmospheric Soundings
Authors: Touzé-Peiffer Ludovic , Vogel Raphaela , Rochetin Nicolas 
Published: March 2022

AbstractA new method is developed to detect cold pools from atmospheric soundings over tropical oceans and applied to sounding data from the Elucidating the Role of Cloud–Circulation Coupling in Climate (EUREC4A) field campaign, which took place south and east of Barbados in January–February 2020. The proposed method uses soundings to discriminate cold pools from their surroundings: cold pools are defined as regions where the mixed-layer height is smaller than 400 m. The method is first tested against 2D surface temperature and precipitation fields in a realistic high-resolution simulation over the western tropical Atlantic Ocean. Then, the method is applied to a dataset of 1068 atmospheric profiles from dropsondes (launched from two aircraft) and 1105 from radiosondes (launched from an array of four ships and the Barbados Cloud Observatory). We show that 7% of the EUREC4A soundings fell into cold pools. Cold-pool soundings coincide with (i) mesoscale cloud arcs and (ii) temperature drops of ∼1 K relative to the environment, along with moisture increases of ∼1 g kg−1. Furthermore, cold-pool moisture profiles exhibit a “moist layer” close to the surface, topped by a “dry layer” until the cloud base level, and followed by another moist layer in the cloud layer. In the presence of wind shear, the spreading of cold pools is favored downshear, suggesting downward momentum transport by unsaturated downdrafts. The results support the robustness of our detection method in diverse environmental conditions and its simplicity makes the method a promising tool for the characterization of cold pools, including their vertical structure. The applicability of the method to other regions and convective regimes is discussed.
Seasonal Differences of Decadal Thermocline Depth Anomalies in the Tropical Indian Ocean
Authors: Sun Shuangwen , Fang Yue , Zu Yongcan , Liu Baochao 
Published: March 2022

Abstract
The thermocline depth in the tropical Indian Ocean has experienced dramatic decadal variations in recent decades. Using analysis and reanalysis datasets, we find that the decadal thermocline depth anomalies show large seasonal differences. The seasonal differences are modulated by two major modes. The first mode shows a zonal dipole pattern, with opposite thermocline depth anomalies in the equatorial eastern Indian Ocean and western Indian Ocean, and is prominent in summer and winter. The second mode is characterized by marked thermocline depth anomalies in the southern Indian Ocean and is significant in spring and fall. The amplitude of the seasonal oscillation in these two modes has increased substantially in the twenty-first century. Their phase change is in good agreement with the observed thermocline depth anomalies in each season. The results also show that the seasonality of the decadal thermocline depth anomalies arises directly from surface wind variations within the Indian Ocean. The first mode is mainly caused by equatorial zonal wind anomalies. The second mode is dominated by local wind stress curl anomalies. These wind anomalies are both significantly correlated with the ENSO-like SST anomalies in the Pacific Ocean. The findings improve our understanding of the decadal thermocline anomalies, and will help to better evaluate their impact on seasonal phase-locked oceanic and atmospheric processes.
What Factors Drive Start-Up Investments in India’s Subnational Economies?
Authors: Gopalan Sasidaran 
Published: March 2022

India has rapidly evolved into a fast-growing emerging market with one of the largest start-up ecosystems in the world. Despite the rapid strides, the nature of investment distribution of start-ups remain heavily concentrated in specific regions within India, fuelling concerns of regional disparities. In this research note, I empirically explore the determinants of start-up investments in India’s subnational economies, to identify the conditioning variables that possibly drive such investments. JEL Codes: L26, O53, R11, R12
Humor: A Grief Trigger and Also a Way to Manage or Live With Your Grief
Authors: Wilson Donna M. , Knox Michelle , Banamwana Gilbert , Brown Cary A. , Errasti-Ibarrondo Begoña 
Published: March 2022

In 2020–2021, a qualitative study was undertaken using an interpretive description methodology to identify what triggers grief in the first 2 years following the death of a beloved family member, and to gain other helpful insights about grief triggers from bereaved Canadian adult volunteers. In that study, a purposive sampling method was used to select 10 bereaved Canadian adult volunteers for in-depth, semi-structured interviews. This paper reports on the humor findings, as revealed to be a particularly complex grief trigger for many participants, as well as a periodic way for most to manage or live with their grief. Participant quotes and an extended discussion are included to illustrate the importance of these humor findings in relation to grief, and to inform bereaved people, bereavement service providers, and the general public about both helpful aspects and some cautionary considerations about humor.
Engagement of specialized palliative care services with the general public: A population-level survey in three European countries
Authors: Vleminck Aline De , Paul Sally , Reinius Maria , Sallnow Libby , Tishelman Carol , Cohen Joachim 
Published: March 2022

Background: There is growing recognition of a need for community capacity development around serious illness, dying and loss, complementary to strategies focussing on health services. Hitherto, little is known about how and to what extent palliative care services in different countries are adopting these ideas in their practices. Aim: To examine views towards and actual involvement in community engagement activities as reported by specialized palliative care services in Belgium, Sweden and the UK. Design, setting, participants: Cross-sectional survey among all eligible specialized palliative care services in Flanders (Belgium) ( n =  50), Sweden ( n =  129) and the UK ( n =  245). Representatives of these services were invited to complete an online questionnaire about their actual activities with the general public and their attitudes regarding such activities. Results: Response rates were 90% (Belgium), 71% (Sweden) and 49% (UK). UK services more often reported engaging with the general public to develop knowledge and skills through a range of activities (80%–90%) compared to Belgian (31%–71%) and Swedish services (19%–38%). Based on a combination of engagement activities 74% of UK services could be labelled as extending their focus beyond the clinical mandate compared to 16% in Belgium and 7% in Sweden. Services’ dependency on charitable donations was strongly associated with increased engagement with the general public. Conclusion: An expansion of the mandate of specialized palliative care services beyond a traditional clinically-oriented focus towards one inclusive of community capacity building around serious illness, dying and loss is occurring in different countries, albeit to different degrees and with different intensities.
Core Muscle Injury: Evaluation and Treatment in the Athlete
Authors: Forlizzi Julianne M. , Ward Mark B. , Whalen James , Wuerz Thomas H. , Gill Thomas J. 
Published: March 2022

Background: Pain in the groin region, where the abdominal musculature attaches to the pubis, is referred to as a “sports hernia,”“athletic pubalgia,” or “core muscle injury” and has become a topic of increased interest due to its challenging diagnosis. Identifying the cause of chronic groin pain is complicated because significant symptom overlap exists between disorders of the proximal thigh musculature, intra-articular hip pathology, and disorders of the abdominal musculature. Purpose: To present a comprehensive review of the pathoanatomic features, history and physical examination, and imaging modalities used to make the diagnosis of core muscle injury. Study Design: Narrative and literature review; Level of evidence, 4. Methods: A comprehensive literature search was performed. Studies involving the diagnosis, treatment, and rehabilitation of athletes with core muscle injury were identified. In addition, the senior author’s extensive experience with the care of professional, collegiate, and elite athletes was analyzed and compared with established treatment algorithms. Results: The differential diagnosis of groin pain in the athlete should include core muscle injury with or without adductor longus tendinopathy. Current scientific evidence is lacking in this field; however, consensus regarding terms and treatment algorithms was facilitated with the publication of the Doha agreement in 2015. Pain localized proximal to the inguinal ligament, especially in conjunction with tenderness at the rectus abdominis insertion, is highly suggestive of core muscle injury. Concomitant adductor longus tendinopathy is not uncommon in these athletes and should be investigated. The diagnosis of core muscle injury is a clinical one, although dynamic ultrasonography is becoming increasingly used as a diagnostic modality. Magnetic resonance imaging is not always diagnostic and may underestimate the true extent of a core muscle injury. Functional rehabilitation programs can often return athletes to the same level of play. If an athlete has been diagnosed with athletic pubalgia and has persistent symptoms despite 12 weeks of nonoperative treatment, a surgical repair using mesh and a relaxing myotomy of the conjoined tendon should be considered. The most common intraoperative finding is a deficient posterior wall of the inguinal canal with injury to the distal rectus abdominis. Return to play after surgery for an isolated sports hernia is typically allowed at 4 weeks; however, if an adductor release is performed as well, return to play occurs at 12 weeks. Conclusion: Core muscle injury is a diagnosis that requires a high level of clinical suspicion and should be considered in any athlete with pain in the inguinal region. Concurrent adductor pathology is not uncommon.
Reliability of a New Arthroscopic Discoid Lateral Meniscus Classification System: A Multicenter Video Analysis
Authors: Lee R. Jay , Nepple Jeffrey J. , Schmale Gregory A. , Niu Emily L. , Beck Jennifer J. , Milewski Matthew D. , Finlayson Craig J. , Joughin V. Elaine , Stinson Zachary S. , Pace J. Lee ,   PRiSM Meniscus Research Interest Group, Albright Jay , Carsen Sasha , Chambers Hank , Nault Marie-Lyne , Schlechter John A. , Stavinoha Tyler J. , Tompkins Marc , Wilson Philip L. , Heyworth Benton E. 
Published: March 2022

Background: The discoid lateral meniscus (DLM) is one of the most common congenital anomalies of the knee. The pathomorphology of DLM varies. Current classification systems are inadequate to describe the spectrum of abnormality. Purpose: A study group of pediatric orthopaedic surgeons from 20 academic North American institutions developed and tested the reliability of a new DLM classification system. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: After reviewing existing classifications, we developed a comprehensive DLM classification system. Four DLM features were evaluated: meniscal width, meniscal height, peripheral stability, and meniscal tear. Stepwise arthroscopic examination using anteromedial and anterolateral viewing portals was established for evaluating these features. Three senior authors who were not observers selected 50 of 119 submitted videos with the best clarity and stepwise examination for reading. Five observers performed assessments using the new classification system to assess interobserver reliability, and a second reading was performed by 3 of the 5 observers to assess intraobserver reliability using the Fleiss κ coefficient (fair, 0.21-0.40; moderate, 0.41-0.60; substantial, 0.61-0.80; excellent, 0.81-1.00). Results: Interobserver reliability was substantial for most rating factors: meniscal width, meniscal height, peripheral stability, tear presence, and tear type. Interobserver reliability was moderate for tear location. Intraobserver reliability was substantial for meniscal width and meniscal height and excellent for peripheral stability. Intraobserver agreement was moderate for tear presence, type, and location. Conclusion: This new arthroscopic DLM classification system demonstrated moderate to substantial agreement in most diagnostic categories analyzed.
Promethazine Downregulates Wnt/β-Catenin Signaling and Increases the Biomechanical Forces of the Injured Achilles Tendon in the Early Stage of Healing
Authors: Sakaguchi Takefumi , Ohkawara Bisei , Kishimoto Yasuzumi , Miyamoto Kentaro , Ishizuka Shinya , Hiraiwa Hideki , Ishiguro Naoki , Imagama Shiro , Ohno Kinji 
Published: March 2022

Background: Wnt/β-catenin signaling suppresses the differentiation of cultured tenocytes, but its roles in tendon repair remain mostly elusive. No chemical compounds are currently available to treat tendon injury. Hypothesis: We hypothesized that the inhibition of Wnt/β-catenin signaling would accelerate tendon healing. Study Design: Controlled laboratory study. Methods: Tendon-derived cells (TDCs) were isolated from rat Achilles tendons. The right Achilles tendon was injured via a dermal punch, while the left tendon was sham operated. A Wnt/β-catenin inhibitor, IWR-1, and an antihistamine agent, promethazine (PH), were locally and intramuscularly injected, respectively, for 2 weeks after surgery. The healing tendons were histologically and biomechanically evaluated. Results: The amount of β-catenin protein was increased in the injured tendons from postoperative weeks 0.5 to 2. Inhibition of Wnt/β-catenin signaling by IWR-1 in healing tendons improved the histological abnormalities and decreased β-catenin, but it compromised the biomechanical properties. As we previously reported that antihistamine agents suppressed Wnt/β-catenin signaling in human chondrosarcoma cells, we examined the effects of antihistamines on TDCs. We found that a first-generation antihistamine agent, PH, increased the expression of the tendon marker genes Mkx and Tnmd in TDCs. Intramuscular injection of PH did not improve histological abnormalities, but it decreased β-catenin in healing tendons and increased the peak force and stiffness of the healing tendons on postoperative week 2. On postoperative week 8, however, the biomechanical properties of vehicle-treated tendons became similar to those of PH-treated tendons. Conclusion: IWR-1 and PH suppressed Wnt/β-catenin signaling and improved the histological abnormalities of healing tendons. IWR-1, however, compromised the biomechanical properties of healing tendons, whereas PH improved them. Clinical Relevance: PH is a candidate repositioned drug that potentially accelerates tendon repair.
COVID-19-related anxieties: Impact on duty to care among nurses
Authors: Ley Cathaleen A , Cintron Christian M , McCamant Karen L , Karpman Mitchell B , Meisenberg Barry R 
Published: March 2022

Background Duty to care is integral to nursing practice. Personal obligations that normally conflict with professional obligations are likely amplified during a public health emergency such as COVID-19. Organizations can facilitate a nurse’s ability to fulfill the duty to care without compromising on personal obligations. Research Aim The study aimed to explore the relationships among duty to care, perception of supportive environment, perceived stress, and COVID-19-specific anxieties in nurses working directly with COVID-19 patients. Research Design The study design was a cross-sectional descriptive study using an online survey. It was conducted at an ANCC Magnet® designated 385-bed acute care teaching hospital located in a suburban area. Participants and Research Context Included in this study were 339 medical surgical nurses working directly with COVID-19 patients during the early phase of the pandemic. Ethical Considerations The study was reviewed by the institution’s clinical research committee and determined to be exempt. A survey invitation letter with a voluntary implied consent agreement was sent to participants with a description of the research study attached to the anonymous survey. Results Nurses with specific COVID-19-related anxieties were more likely to agree that it was ethical to abandon the workplace during a pandemic. Conclusions Organizations can and ought to mitigate the negative effects of COVID-19 on duty to care in future pandemics and healthcare emergencies by incorporating several recommendations derived from this study.