bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Nieve del Almirante, de Álvaro Mutis: un análisis interdisciplinario del existencialismo en Maqroll
Authors: Paniagua Gutiérrez Edwin Rafael 
Published: June 2022

El presente estudio se concentra en La Nieve del Almirante (Álvaro Mutis)1, considerada una de las novelas de viaje más importantes de la literatura latinoamericana. La historia gira en torno a Maqroll el Gaviero (personaje central), quien debe decidir entre dos destinos irreconciliables: permanecer junto a Flor Estévez (su amor ideal e idealizado) o partir en pos de los aserraderos. El objetivo principal es analizar las acciones del protagonista (Maqroll) integrando la crítica literaria y la perspectiva filosófica para demostrar que en ellas predomina el existencialismo. En concreto, se aplica un esquema narratológico mínimo (contextualización de la obra, acciones e intenciones del personaje principal y tipo de narrador, por ejemplo) y se realiza una aproximación filosófica, desde el existencialismo, para caracterizar a Maqroll con base en sus acciones más relevantes. De este modo, se aborda su trayectoria desde un enfoque transdiciplinario. En síntesis, se demuestra que Maqroll actúa acorde con los postulados del existencialismo (existencia-libertad-elección-angustia), más que con los del determinismo (como el personaje de Arturo Cova en La vorágine, quien actúa impulsado por las situaciones y no por voluntad propia). El análisis del texto permite plantear la tesis de que el Gaviero se presenta como un ser humano que decide libremente (actúa con plena voluntad) y se angustia por las implicaciones de sus acciones.
Outcomes of Lymphadenectomy for Early-Stage Mucinous Ovarian Cancer: A Retrospective Study Based on Surveillance, Epidemiology, and End Results (SEER) Database
Authors: Cheng Xiaqin , Zeng Zhen , Cui Lanyue , Li Jundong 
Published: June 2022

Objective: To evaluate the efficacy of lymphadenectomy for early-stage
primary mucinous ovarian cancer (MOC). Design: Retrospective observation
study Setting: Surveillance, Epidemiology, and End Results (SEER)
database for 2000-2018 Population or sample: The study population
comprised 1848 patients with early-stage MOC Methods: MOCs were divided
into two groups according to lymphadenectomy. Propensity score matching
were performed to correct for deviations. Independent risk factors for
overall survival (OS) were determined by multivariate analysis using Cox
regression. The role of lymphadenectomy was performed in different
populations by stratified analysis applying interaction analysis. OS was
calculated by Kaplan-Meier curves and compared by log-rank test. Main
outcome measures: Overall survival Results: In the study, almost 65.8%
(n = 1214/1848) experienced lymphadenectomy. Lymphadenectomy (HR =
0.692, 95% CI = 0.516-0.927, P = 0.009), age at diagnosis (HR = 3.028,
95% CI = 1.477-6.208, P = 0.002), and laterality (HR = 2.013, 95% CI =
1.145-3.54, P = 0.015) were found to be associated with OS. The role of
lymphadenectomy varied by age group and tumor laterality, and the 5-year
survival rates of patients with bilateral tumors who had experienced
lymphadenectomy with sampling and dissection, or for MOC over age 50 and
were higher than that of patients who did not undergo lymphadenectomy.
Conclusion: Lymphadenectomy with sampling and dissection has little
impact on OS in patients with early MOC. Lymph node therapy can be
discontinued in patients younger than 50 years, and lymph node sampling
is recommended for patients older than 50 years or with bilateral
tumors.
Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program
Authors: Perreault Leigh , Davies Melanie , Frias Juan P. , Laursen Peter Nørkjaer , Lingvay Ildiko , Machineni Sriram , Varbo Anette , Wilding John P.H. , Wallenstein Signe Olrik Rytter , le Roux Carel W. 
Published: June 2022

OBJECTIVE
This analysis of 3,375 adults with overweight/obesity across the Semaglutide Treatment Effect in People with obesity (STEP) 1, 3, and 4 trials evaluated whether more participants with prediabetes had normoglycemia after 68 weeks’ treatment with once-weekly semaglutide 2.4 mg plus lifestyle intervention versus placebo and assessed changes in glucose metabolism in participants with prediabetes.

RESEARCH DESIGN AND METHODS
STEP 1, 3, and 4 were phase 3, 68-week, randomized, placebo-controlled, multinational trials; STEP 4 had a 20-week semaglutide run-in and 48-week randomized period. Analyses included changes (week 0–68; before the washout period) in glycemic status (prespecified: STEP 1 and 3; post hoc: STEP 4), and in HbA1c, fasting plasma glucose (FPG), and HOMA insulin resistance (HOMA-IR) among participants with prediabetes (post hoc).

RESULTS
Significantly more participants with baseline (week 0) prediabetes (n = 1,536) had normoglycemia at week 68 with semaglutide versus placebo (STEP 1, 84.1% vs. 47.8%; STEP 3, 89.5% vs. 55.0%; STEP 4, 89.8% vs. 70.4%; all P &lt; 0.0001). Fewer participants with baseline normoglycemia had prediabetes at week 68 with semaglutide versus placebo (STEP 1, 2.9% vs. 10.9%; STEP 3, 3.2% vs. 5.8%; STEP 4, 1.1% vs. 5.0%). Semaglutide resulted in greater improvements in HbA1c, FPG, and HOMA-IR than placebo among participants with baseline prediabetes (all P &lt; 0.01).

CONCLUSIONS
STEP 1, 3, and 4 collectively provide a robust assessment of the effects of semaglutide on glucose metabolism and prediabetes in a large cohort of adults with overweight/obesity while on treatment. Among participants with baseline prediabetes, 68 weeks’ treatment with semaglutide versus placebo led to significant improvements in glucose metabolism and a higher likelihood of normoglycemia.
Seleção de um conjunto de indicadores com base nas ISOs 9001, 14001 e 16001 aderentes às micro e pequenas empresas
Authors: Reiter Iane de Brito , Feil Alexandre André 
Published: June 2022

A utilização integrada das normas ISO 9001, 14001 e 16001 como estratégia para melhorar o desempenho da gestão por intermédio de indicadores pode ser uma possibilidade de as organizações avançarem em direção à sustentabilidade. Neste contexto, este estudo objetivou identificar e selecionar um conjunto de indicadores com base nas ISOs 9001, 14001 e 16001 para auxiliar na gestão de forma integrada das micro e pequenas empresas em direção a sustentabilidade. Os procedimentos metodológicos na condução desta pesquisa em relação à abordagem foram qualiquantitativa, descritiva, e quanto aos procedimentos técnicos utilizou-se a pesquisa documental, bibliográfica e survey. A amostra da pesquisa survey (questionário) com escala likert de cinco pontos, não é probabilística e escolhida por conveniência, de 125 gestores de micro e pequenas empresas. Os principais resultados revelam que o perfil dos respondentes se mostrou qualificado e com experiência na gestão das organizações em função do elevado nível de escolaridade e do tempo de atividade. O conjunto de indicadores selecionados, com base no nível de consenso, totalizam 35, distribuídos em sete indicadores ambientais, 13 indicadores sociais e 15 indicadores econômicos e de gestão. Este conjunto de indicadores abrange de forma holística as micro e pequenas empresas e seus stakeholders podendo auxiliar na gestão em direção a sustentabilidade.
PENGEMBANGAN MEDIA AUDIO VISUAL BAHASA INDONESIA BERBASIS HOTS MATERI HIDUP BERSIH DAN SEHAT (Penelitian Design and Development di Kelas II SD Negeri Kedokan)
Authors: Namiroh Salma 
Published: June 2022

Abstract This research is motivated by the lack of procurement of variety of learning media integrated with technology in thematic learning of clean and healthy living materials, especially in Indonesian language learning. This makes students find it difficult to receive learning materials. In addition, the demands of 21st century education also require integrating learning with technology and developing high-level thinking skills or HOTS. Based on this, the researcher intends to develop indonesian audio visual media based on HOTS clean and healthy living materials for students of grade II of Kedokan State Elementary School. This research uses design and development methods with addie model. Based on the results of validation provided, the research products that have been developed by researchers fall into the category of "Very Worthy" with a percentage of eligibility of 94% of material experts and 86.75% of media experts. The use of HOTS-based Indonesian audio visual media also received a positive response from teachers and students of grade II of Kedokan State Elementary School who were participants in this study, with a percentage of media eligibility scores of 100% from teachers and 94.25% of students.Keywords: 21st Century Education, Media Development, Audio Visual Media, Higher Order Thinking Skills AbstrakPenelitian ini dilatarbelakangi oleh minimnya pengadaan variasi media pembelajaran yang terintegrasi dengan teknologi pada pembelajaran tematik materi hidup bersih dan sehat, khususnya pada pembelajaran Bahasa Indonesia. Hal tersebut membuat siswa merasa kesulitan dalam menerima materi pembelajaran. Disamping itu, tuntutan pendidikan abad ke-21 juga mengharuskan pengintegrasian pembelajaran dengan teknologi serta mengembangkan keterampilan berpikir tingkat tinggi atau HOTS. Berdasarkan hal tersebut, maka peneliti bermaksud untuk mengembangkan media audio visual Bahasa Indonesia berbasis HOTS materi hidup bersih dan sehat untuk siswa kelas II SD Negeri Kedokan. Penelitian ini menggunakan metode Design and Development dengan model ADDIE. Berdasarkan hasil validasi yang diberikan, maka produk penelitian yang telah dikembangkan oleh peneliti termasuk ke dalam kategori “Sangat Layak” dengan presentase kelayakan sebesar 94% dari ahli materi dan 86,75% dari ahli media. Penggunaan media audio visual bahasa Indonesia berbasis HOTS juga mendapatkan respon positif dari guru dan siswa kelas II SD Negeri Kedokan yang menjadi partisipan dalam penelitian ini, dengan nilai presentase kelayakan media sebesar 100% dari guru dan 94,25% dari siswa.Kata Kunci: Pendidikan Abad ke-21, Pengembangan Media, Media Audio Visual, Higher Order Thinking Skills
Black Soybean (Glycine max (L.) Merr.) 30% Ethanol Extract Cream Inhibited The Increase of Tyrosinase Enzyme Expression and The Amount of Melanin Same Effective as 4% Hydroquinone Cream on Guinea Pig (Cavia porcellus) Skin
Authors: Johan Yanvi , Wiraguna Anak Agung Gde Putra , Dewi Ni Nyoman Ayu 
Published: June 2022

Background: Hyperpigmentation is one of the signs of skin aging which is mostly caused by Ultraviolet B (UVB) rays exposure. The gold standard for hyperpigmentation therapy is hydroquinone (HQ) but its long-term use can cause side effects such as irritation, rebound phenomenon, and even ochronosis. Black soybeans contain active ingredients that can prevent the increase of tyrosinase enzyme and the amount of melanin so that it can be used as an alternative therapy for hyperpigmentation. This study aims to prove that the administration of 30% black soybean extract cream was as effective as 4% HQ cream in inhibiting the increase of tyrosinase enzyme expression and the amount of melanin in guinea pig skin exposed to UVB rays.
Methods: This study used a post-test only control group design method with 30 guinea pigs as samples. The sample was divided into three groups of 10 each. The P1 group was given the base cream, the P2 group was given the 4% HQ cream, while the P3 group was given the 30% black soybean extract cream. Each group was exposed to UVB rays with a total dose of 390mJ/cm2 for 2 weeks, after that the guinea pig skin tissue was taken and histopathological preparations were made for examination of tyrosinase enzyme expression and the amount of melanin. The data obtained were analyzed using one way ANOVA, then the differences between groups were analyzed using the Least Significant Difference (LSD) test.
Results: The results showed that the mean of the tyrosinase enzyme expression and the amount of melanin in the black soybean extract group P3 (12.880±3.327% and 3.16±1.486) were not significantly different from the HQ4% group P2 (9.690±2.176% and 2.18±1.117), while the mean of the base cream group P1 (25.78±5.392% and 12.080±3.150) was the highest among the three groups. The LSD test showed a significant difference between the base cream group (P1) and the other groups (p<0.01), but there was no significant difference between the 4% hydroquinone group (P2) and the 30% black soybean extract treatment group (P3) (p >0.05).
Conclusion: The conclusion of this study was that 30% black soybean ethanol extract cream inhibited the increase of tyrosinase enzyme expression and the amount of melanin as effective as 4% HQ cream on guinea pig skin exposed to UVB light.
Noticia del proyecto y construcción del ferrocarril Ribes-Queralbs-Núria, en el Pirineo de Girona
Authors: Gorini Santo Carles 
Published: June 2022

La investigación en el fondo documental de la sociedad de Ferrocarriles de Montaña a Grandes Pendientes, S.A. (F.M.G.P.), que custodia Ferrocarrils de la Generalitat de Catalunya (F.G.C.), ha revelado la dimensión del proyecto de aquella sociedad en el valle de Núria, que se gestó entre 1924 y 1931, y que era en parte desconocido. También, ha proporcionado evidencias de valor sobre las condiciones del trabajo durante la construcción de la línea y otras informaciones relativas a esa ejecución, como la característica de los contratistas y los proveedores. El trabajo que presentamos constituye, pues, una aportación al conocimiento de los procesos de planificación y ejecución de los ferrocarriles secundarios catalanes
Perancangan Kampanye Social Movement Bahaya Smartphone bagi Anak
Authors: Pravitasari Indriati Suci 
Published: June 2022

Abstrak
Manusia sekarang ini tidak lepas dari sarana komunikasi yaitu smartphone, saat ini smartphone mengalami perkembangan yang sangat pesat terutama pada operasi sistem serta program dan aplikasi yang digunakan dalam setiap smartphone, yang dapat meningkatkan kemudahan operasi tiap smartphone. Berbagai perkembangan kemajuan tentu memiliki dua dampak, positif dan negatif. Berbagai fitur dan aplikasi canggih yang ditawarkan dalam smartphone penggunanya betah berlama-lama menatap layar dalam waktu yang cukup lama. Fungsi smartphone kini tidak hanya sebagai sarana komunikasi semata, namun berubah sebagai gaya hidup. Para pengguna smartphone tidak hanya di kalangan usia dewasa dan remaja saja namun, kini sudah sampai pada anak-anak, padahal anak-anak belum mampu memfilter dan membedakan mana yang baik dan tepat bagi dirinya, pada berbagai kecanggihan pada fitur-fitur smartphone. Pada perancangan ini maka pendekatan komunikasi visual dengan menggunakan sosial media, selain layak diterapkan juga dinilai tepat dalam mengikuti arus perkembangan smartphone, dan sosial media merupakan media kampanye yang paling ampuh sebagai sarana dalam menjembatani sebuah pesan bagi target audience dalam perancangan ini.

Abstract
Humans today are inseparable from the means of communication, smartphones, nowadays smartphones are experiencing very rapid development, especially in operating systems and programs and applications used in each smartphone, which can improve the ease of operation of each smartphone. Various developments in progress certainly have two effects, positive and negative. Various advanced features and applications offered in the smartphone, the users feel at home for a long time staring at the screen for quite a long time. The function of smartphone now is not only a means of communication, but changes as a lifestyle. Smartphone users are not only among adults and adolescents, but now it has reached children, even though the children have not been able to filter and differentiate what is good and right for themselves, on the various sophistication of smartphone features. In
this design the visual communication approach using social media, in
addition to being feasible to be applied is also considered appropriate in
following the development of smartphones, and social media is the most powerful campaign media as a means of bridging a message for the target audience in this design.
Bunga Anggrek Hitam sebagai Ide Penciptaan Karya Batik pada Kain Tenun Ulap Doyo (Black Orchid Flower as an Idea for the Creation of Batik in Doyo Ulap Woven Fabrics)
Authors: Indah Sari Irma 
Published: June 2022

AbstrakKekaguman penulis akan bunga anggrek hitam menggugah keinginan penulis untuk melestarikan tanaman alam Kalimantan ini, dengan cara membuat suatu karya seni dengan konsep batik yang mengangkat tema bunga anggrek hitam. Dengan pembuatan karya ini penulis berharap agar masyarakat memiliki kepedulian dan kesadaran terhadap bunga anggrek hitam dan alam habitatnya. Karya batik ini akan dituangkan di atas tenun Ulap Doyo yang berasal dari serat daun doyo khas Kalimantan Timur. Dalam pembuatan karya seni ini, metode pendekatan yang digunakan adalah pendekatan estetika dan pendekatan empiris, sedangkan metode penciptaan yang digunakan ialah metode penciptaan S.P. Gustami, yakni eksplorasi, perancangan, perwujudan. Karya batik tulis ini menggunakan teknik batik tradisional dengan menggunakan proses canting, teknik pewarnaan sintesis celup tutup, colet dan proses lorodan. Karya ini merupakan karya batik yang dipadukan dengan tenun ulap doyo. Karya yang dihasilkan berupa karya panel yang berfungsi sebagai hiasan interior, dirasakan sangat fleksibel karena bisa untuk hiasan interior di mana saja, selain mudah diapresiasi dan menyampaikan pesan juga dapat mendorong inspirasi ekonomi kreatif kearifan lokal masyarakat setempat.AbstractThe admiration of the authors of black orchid flowers aroused the writer's request to preserve this natural Kalimantan plant, by making artworks with the concept of batik that raised the theme of black orchid flowers. By making this work the author hopes that the community has concern and awareness of the black orchid flower and its natural habitat. This batik work will be poured on the woven Ulap Doyo which comes from doyo leaf fibers typical of East Kalimantan. Making a senior work, the method used is discussing aesthetics and asking for empirical, while the method used is the method that uses S.P. Gustami, namely exploration, design, embodiment. This written batik works using traditional batik techniques using the canting process, the dye synthesis technique, the colet, and the lorodan process. This work is batik work combined with doyo weaving. The work produced by the panel made of interior decoration is accepted to be very flexible because it can only be interior decoration, besides being easily appreciated and conveyed the message can also encourage creative economic inspiration of local wisdom of the local community.
Kerajinan Kayu Ornamen Cukli dengan Teknik Mozaik untuk Menambah Nilai Estetik
Authors: Anggriani Swastika Dhesti , Sidyawati Lisa , Prasetyo Abdul Rahman 
Published: June 2022

Artikel ini bertujuan untuk menambah nilai fungsi (multifungsi) pada produk kerajinan kayu dengan menambahkan ornamen kerang cukli. Produk kerajinan yang digunakan adalah nampan dan sendok-garpu dari material kayu. Ornamen ditambahkan pada permukaan kayu dengan mengaplikasikan material kerang cukli. Pemilihan produk nampan dan sendok-garpu kayu didasari dari melimpahnya material kayu di Indonesia dan produk kayu dinilai relatif mudah untuk dikombinasikan dengan material lain dengan menggunakan teknik mozaik. Metode yang digunakan adalah metode perancangan yang meliputi tahap eksplorasi, perancangan, dan perwujudan. Hasil yang diproleh adalah karya kerajinan kayu nampan dan sendok-garpu yang telah diberi ornamen dari kerang cukli. Hasil karya kerajinan memiliki banyak fungsi/multifungsi setelah diberi ornamen dari kerang cukli. Cukli Ornament Wood Craft with Mosaic Techniques to Add Value to the Function ABSTRACTThis article aims to add value to the function (multifunction) of wooden handicraft products by adding ornament from cukli shells material. Craft products used are wooden trays and cutlery. Ornaments are added to the surface of the wood by applying cukli shell material. The selection of wooden trays and cutlery is based on the abundance of wood materials in Indonesia and wood products are considered relatively easy to combine with other materials using mosaic techniques. The method used is the design method which includes the exploration, design, and embodiment stages. The results obtained are the work of woodcraft trays and cutlery that have been given ornaments from cukli shells material. The handicraft works have many functions (multifunction) after being given ornamentation from cukli shells material.
Perspektif Pendidikan Seni Musik Berorientasi Humanistik
Authors: Prabawa Anarbuka Kukuh , Pradoko A.M Susilo , Handoyo Cipto Budi 
Published: June 2022

Kajian ini merupakan analisis kritis terhadap konsep pendidikan seni musik yang berorientasi humanistik. Permasalahan mendasar yakni kondisi pembelajaran belum sepenuhnya maksimal, mengingat tidak terpenuhinya hakikat pembelajaran yang sesungguhnya. Selain masalah tersebut, pendidikan seni musik belum mampu memberikan kebebasan dan kematangan personal sebagai subjektivitas. Penyebabnya, kurangnya usaha menumbuhkan rasa kesadaran diri dan tanggung jawab kepada individu siswa. Tujuan kajian ini untuk memberikan kesadaran terhadap pendidik agar mampu mengarahkan siswa menggali pengalaman eksplorasi dalam bermusik dan mendekatkan pada lingkungan sekitar. Kajian ini menggunakan metode analisis literasi berorientasi humanistik dari berbagai perspektif para pakar yang kompeten. Hasil penelitian ini memberikan pertimbangan terhadap pendidikan seni musik untuk berbenah dengan mengutamakan pengalaman siswa melalui unsur-unsur seni musik meliputi cara berekspresi, apresiasi, kreasi, dan membentuk harmonisasi dengan lingkungan. Kesimpulannya, pendidik seni musik dituntut mampu untuk memberikan dorongan, motivasi, serta dukungan untuk pencarian jati diri siswa dalam menemukan pengetahuan, keterampilan, dan sikap positif dengan menyesuaikan karakter individu dengan lingkungan sekitarnya. The Perspective of Humanistic Oriented Music Education ABSTRACT This study is a critical analysis of the concept of music education with a humanistic orientation. The fundamental problem is that the learning conditions have not been fully maximized, considering that the true essence of learning is not fulfilled. Apart from these problems, music education has not provided freedom and personal maturity as subjectivity. The reason is a lack of effort to foster a sense of self-awareness and responsibility to individual students. This study aims to provide awareness to educators to be able to direct students to explore exploration experiences in music and get closer to the surrounding environment. This study uses a humanistic-oriented literacy analysis method from various perspectives of competent experts. This study's results provide consideration for music education to improve by prioritizing student experience through musical art elements, including ways of expression, appreciation, creation, and forming harmony with the environment. In conclusion, music educators must provide encouragement, motivation, and support for the search for student identity in finding knowledge, skills, and positive attitudes by adjusting individual character to the surrounding environment.