bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Efficacy and Safety of Traditional Medicine Preparations Combined With Chemotherapy for Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis
Authors: Hu Jiaqi , Jiang Juling , Liu Rui , Cheng Mengqi , Zhu Guanghui , He Shulin , Shi Bolun , Zhao Yuwei , He Zhongning , Yu Huibo , Zhang Xing , Zheng Honggang , Hua Baojin 
Published: February 2022

BackgroundTraditional medicine preparations (TMPs) combined with chemotherapy is widely used for patients with advanced pancreatic cancer (APC); however, its efficacy and safety are still unclear. The purpose of this meta-analysis was to evaluate the clinical efficacy and safety of TMPs combined with chemotherapy for the treatment of APC.MethodsA systematic search of eight electronic databases for randomized controlled trials (RCTs) was conducted from inception to October 15, 2021. Tumor response was identified as primary outcome, whereas quality of life (QoL), cancer biomarkers, and adverse drug reactions (ADRs) were identified as secondary outcomes. Quality of the evidence for each outcome was evaluated by GRADE profiler.ResultsIn total, 31 RCTs involving 1,989 individuals were included. This meta-analysis showed that TMPs combined with chemotherapy significantly improved the objective response rate (ORR) (RR=1.64, 95% CI [1.43 to 1.88], p &lt;0.00001), disease control rate (DCR) (RR=1.29, 95% CI [1.21 to 1.38], p &lt;0.00001), and QoL (continuous data: SMD=0.81, 95% CI [0.44 to 1.18], p &lt;0.0001, dichotomous data: RR=1.44, 95% CI [1.22 to 1.70], p&lt;0.0001), compared to those with chemotherapy alone. In addition, the combined treatment group also had lower levels of CA19-9 (SMD=-0.46, 95% CI [-0.90 to -0.02], p=0.04) and CEA (SMD=-0.55, 95% CI [-0.93 to -0.17], p=0.004). Moreover, TMPs reduced the ADRs during chemotherapy.ConclusionThis systematic review suggests that TMPs combined with chemotherapy might be a potential option to enhance therapeutic effects and reduce ADRs during the treatment of APC. However, more high-quality randomized controlled trials with more participants are needed.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=209825, identifier PROSPERO Number: CRD42021264938.
Effect of Abdominal Circumference on the Irradiated Bowel Volume in Pelvic Radiotherapy for Rectal Cancer Patients: Implications for the Radiotherapy-Related Intestinal Toxicity
Authors: Wang Gang , Wang Wenling , Jin Haijie , Dong Hongmin , Chen Weiwei , Li Xiaokai , Bai Saixi , Li Guodong , Chen Wanghua , Li Leilei , Chen Juan 
Published: February 2022

BackgroundTo effectively reduce the irradiated bowel volume so as to reduce intestinal toxicity from pelvic radiotherapy, treatment in the prone position with a full bladder on a belly board is widely used in pelvic radiotherapy for rectal cancer patients. However, the clinical applicable condition of this radiotherapy mode is unclear. The aim of this study was to preliminarily identify patients who were not eligible for this radiotherapy mode by analyzing the effect of abdominal circumference on the irradiated bowel volume.MethodsFrom May 2014 to September 2019, 179 patients with locally advanced rectal cancer were retrospectively reviewed in our center. All patients received pelvic radiotherapy. Weight, height, AC, and body mass index (BMI) were used as the research objects, and the irradiated bowel volume at different dose levels (V10, V20, V30, V40, V50) was selected as the outcome variable. Multivariate linear regression and sensitivity analyses were used to evaluate the correlation between AC and irradiated bowel volume. Generalized additive model (GAM) and piecewise linear regression were used to further analyze the possible nonlinear relationship between them.ResultsAmong the four body size indicators, AC showed a negative linear correlation with the irradiated bowel volume, which was the most significant and stable. In adjuvant radiotherapy patients, we further discovered the threshold effect between AC and irradiated bowel volume, as AC was greater than the inflection point (about 71 cm), irradiated bowel volume decreased rapidly with the increase in AC. t-test showed that in patients with small AC (&lt;71 cm), the irradiated bowel volume was significantly higher than that of patients with medium-large AC (≥71 cm). Especially in patients with adjuvant radiotherapy, the mean irradiated bowel volume of patients with small AC was the highest in this study. Compared with adjuvant radiotherapy, in neoadjuvant radiotherapy, the mean difference of irradiated bowel volume between patients with medium-large AC and those with small AC was larger.ConclusionAC is an independent factor influencing the irradiated bowel volume and has a strong negative linear correlation with it. Patients with small AC may not benefit from this common mode of radiotherapy, especially in adjuvant radiotherapy.
LncRNA-AC068228.1 Is a Novel Prognostic Biomarker That Promotes Malignant Phenotypes in Lung Adenocarcinoma
Authors: Jiang Xiulin , Chen Min , Du Junyi , Bi Hong , Guo Xiang , Yang Chao , He Xu , Jin Zhixian 
Published: February 2022

BackgroundThe crucial roles played by lncRNA-AC068228.1 in primary malignant cancer remain poorly understood. This study aimed at examining the clinical significance and evaluating the biological function of AC068228.1 in lung adenocarcinoma (LUAD).MethodsWe used data obtained from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and the Gene Expression Omnibus (GEO) database to examine the expression of AC068228.1 in LUAD patients, and the prognostic and diagnostic value of those levels. Functional experiments were conducted to determine the function of AC068228.1 on LUAD cells. Signaling pathway enrichment analysis of AC068228.1 was conducted using the clusterProfiler and Gene Set Enrichment Analysis (GSEA) software. We analyzed the correlation between AC068228.1 expression and immune infiltration level in LUAD using the single-sample gene set enrichment analysis (ssGSEA) method by the R package GSVA.ResultsAC068228.1 expression was significantly elevated in LUAD tissues compared with normal tissues. Higher expression of AC068228.1 was strongly correlated with adverse clinical outcomes and was identified as an independent prognostic marker for LUAD patients. GSEA and infiltration analysis confirmed that AC068228.1 expression was significantly correlated with immune cells infiltrating in LUAD. Knockdown of AC068228.1 inhibited the cell proliferation and cell migration of LUAD.ConclusionsAC068228.1 was upregulated in LUAD and was significantly correlated with adverse clinical outcomes. Meanwhile, it was associated with immune cell infiltration and could be used as a promising diagnostic and prognostic biomarker for LUAD patients.
The Impact of Poor Nonverbal Social Perception on Functional Capacity in Schizophrenia
Authors: Chapellier Victoria , Pavlidou Anastasia , Maderthaner Lydia , von Känel Sofie , Walther Sebastian 
Published: February 2022

BackgroundNonverbal social perception is the ability to interpret the intentions and dispositions of others by evaluating cues such as facial expressions, body movements, and emotional prosody. Nonverbal social perception plays a key role in social cognition and is fundamental for successful social interactions. Patients with schizophrenia have severe impairments in nonverbal social perception leading to social isolation and withdrawal. Collectively, these aforementioned deficits affect patients’ quality of life. Here, we compare nonverbal social perception in patients with schizophrenia and controls and examine how nonverbal social perception relates to daily functioning.MethodsWe compared nonverbal social perception in 41 stable outpatients with schizophrenia and 30 healthy controls using the Mini Profile of Nonverbal Sensitivity (Mini-PONS). The participants evaluated 64 video clips showing a female actor demonstrating various nonverbal social cues. Participants were asked to choose one of two options that best described the observed scenario. We correlated clinical ratings (Positive and Negative Syndrome Scale, Brief Negative Syndrome Scale), Self-report of Negative Symptoms, and functional assessments (functional capacity and functional outcome) with Mini-PONS scores.ResultsPatients performed significantly poorer in the Mini-PONS compared to controls, suggesting deficits in nonverbal social perception. These deficits were not associated with either positive symptoms or negative symptoms (including self-report). However, impaired nonverbal social perception correlated with distinctive domains of BNSS (mainly avolition and blunted affect), as well as functional capacity and functional outcome in patients.ConclusionWe demonstrate that nonverbal social perception is impaired in stable outpatients with schizophrenia. Nonverbal social perception is directly related to specific negative symptom domains, functional capacity and functional outcome. These findings underline the importance of nonverbal social perception for patients’ everyday life and call for novel therapeutic approaches to alleviate nonverbal social perception deficits.
Evolution of Hot and Dense Stellar Interiors: The Role of the Weak Interaction Processes
Authors: Kosmas T. S. , Tsoulos I. , Kosmas O. , Giannaka P. G. 
Published: February 2022

The evolution of the hot and dense interior of massive stars has aroused the intense interest of researchers the last more than three decades. In this article, the role of the semi-leptonic weak interaction processes of leptons (involving neutrinos) with nucleons and nuclei in the late stages of stellar evolution, as well as in the relevant terrestrial neutrino detection experiments, is reviewed. Such processes play crucial role for the massive stars’ evolution in the final stages of their life, and specifically in the core-collapse supernova leading to the supernova explosion phenomenon. We start by mainly focusing on the neutrino producing charged-lepton capture, like the electron-capture and the muon-capture on nuclei and, then, we discuss the neutrino absorbing reactions which are essential in the neutrino-driven explosive nucleo-synthesis. These processes are also significant in many ongoing and planned worldwide underground sensitive experiments aiming to detect astrophysical neutrinos which rely on the interactions of neutrinos with the bound nucleons inside atomic nuclei.
How do European Mature Adults and Elderly Perceive SARS-COV-2 and Associated Control Measures? A Cross-Country Analysis of Mental Health Symptoms in June and July 2020
Authors: Perelman Julian , Xavier Miguel , Barros Pedro Pita 
Published: February 2022

Objectives: Recent literature points out that elderly people are psychologically resilient to COVID-19, but the studies were performed in specific contexts. We measured the link between the worsening of mental health symptoms, the epidemiologic situation, and control measures among European people aged 50 or older.Methods: We used data from the 2020 wave of SHARE, merged with Oxford COVID-19 Government Response Tracker data (n = 38,358). We modeled the risk of worsening of depression, anxiety, sleeping trouble, and loneliness symptoms’ self-perception, as functions of control measures and 7-days death incidence, using logistic regressions.Results: The worsening of anxiety and depression perception were more common (16.2 and 23.1%, respectively), compared to that of sleeping troubles and loneliness (8.1 and 11.5%, respectively). The worsening of depression and anxiety perception was negatively related to the rigor of control measures. The seven-days death incidence was positively linked to all symptoms except sleeping troubles.Conclusion: Older people were the most exposed to death risk and were affected psychologically by the COVID-19 epidemiological situation; yet control measures were protective (or neutral) to their mental health condition.
Usage of Morphological Mutations for Improvement of a Garden Pea (Pisum sativum): The Experience of Breeding in Russia
Authors: Sinjushin Andrey , Semenova Elena , Vishnyakova Margarita 
Published: February 2022

The improvement of pea as a crop over many decades has been employing the use of mutants. Several hundreds of different mutations are known in pea (Pisum sativum subsp. sativum), some of which are valuable for breeding. Breeding strategies may be diverse in different countries depending on different obstacles. In Russia, numerous spontaneous and induced mutations have been implemented in breeding. To our knowledge some of these, are not used in pea breeding beyond Russia. This review describes the use of mutations in pea breeding in Russia. The paper provides examples of cultivars created on the basis of mutations affecting the development of seeds (def), inflorescence (det, deh), compound leaves (af, af unitac), and symbiotic nitrogen fixation (various alleles of Sym and Nod loci). Novel mutations which are potentially promising for breeding are currently being investigated. Together with numerous cultivars of dry and fodder pea carrying commonly known mutations, new ‘chameleon’ and ‘lupinoid’ morphotypes, both double mutants, are under study. A cultivar Triumph which increases the effectiveness of interactions with beneficial soil microbes, was bred in Russia for the first time in the history of legume breeding.
Pengaruh Anggaran Terhadap Kinerja Manajerial pada PT. Duta Marga Lestarindo
Authors: Nasution Lukman , Ichsan Reza Nurul 
Published: February 2022

This study aims to determine and analyze the influence of budget on managerial performance at PT. Ambassador Marga Lestarindo Medan. So the formulation of the problem is "What is the Influential Perspective on Managerial Performance at PT. Ambassador Marga Lestarindo Medan ". Collecting method used is literature research and field research and data analysis that is descriptive method and simple linear regression analysis to test the influence of dependent variable and independent variable. Can be concluded from the test results obtained tcount> ttable (8.143> 2.048) which means that the budget has a significant effect on managerial performance. Regression value obtained is Y = 4.357 + 0.786X, can mean that managerial performance will be worth of 4.357 when the budget value is 0 (no). And the value of X = 0.786 states that the increase in budget will increase managerial performance by 0.786. Value R2 = 0.703, meaning that the effect of the influence of managerial performance of 70.3%.
Modern Aspects of Herpetic Infection with Manifestations in the Oral Cavity
Authors: Попруженко Т.В. , Терехова Т.Н. , Боровая М.Л. , Белая Т.Г. 
Published: February 2022

Пандемический характер вызываемой вирусами простого герпеса (ВПГ) пожизненной инфекции, широкий диапазон патогенных эффектов ВПГ в организме человека, риск тяжелого течения первичной и рецидивирующей ВПГ-инфекции при недостаточной иммунной защите пациента требуют от каждого врача компетентности в области герпетической инфекции. В публикации приведены базовые и современные сведения о ВПГ-инфекции с акцентом на ее проявлениях в полости рта у детей и взрослых из общей популяции и с выраженным иммунодефицитом. Цель работы – обновить и систематизировать знания врачей-стоматологов о патогенезе первичной и хронической ВПГ-инфекции, ее оральных и системных признаках, об особенностях клинической и лабораторной диагностики ВПГ-патологии с проявлениями в полости рта, а также о стратегии и тактике лечения пациентов с герпетическим поражением слизистой оболочки полости рта и красной каймы губ на основе принципов доказательной медицины и действующих в Республике Беларусь клинических протоколов, а также о доступных в настоящее время мерах профилактики распространения ВПГ I и ВПГ II.
The pandemic nature of lifelong infection caused by herpes simplex viruses (HSV), a wide range of pathogenic effects of HSV in the human, the risk of a severe course of primary and recurrent HSV infection with insufficient patient’s immune defense require every doctor to have confident competence in the field of herpes infection. The publication provides basic and current information about HSV infection with an emphasis on its manifestations in the oral cavity in children and adults from the general population and with severe immunodeficiency. The purpose of the work is to update and systematize the knowledge of dentists on the pathogenesis of primary and chronic HSV infection, its oral and systemic signs, on the features of clinical and laboratory diagnosis of HSV pathology with manifestations in the oral cavity, as well as on the strategy and tactics of treating patients with herpes simplex. lesions of the oral mucosa and the red border of the lips based on the principles of evidence-based medicine and clinical protocols in force in the Republic of Belarus, as well as the currently available measures to prevent the spread of HSV I and HSV II.
Profession of a Genetic Consultant: Formation and Modern Development Trends
Authors: Головатая Е.И. , Прибушеня О.В. 
Published: February 2022

Статья посвящена истории возникновения и развития профессии генетического консультанта. Рассматриваются этапы развития медицинской генетики и зарождение генетического консультирования. Накопленные после завершения проекта «Геном человека» данные привели к усложнению представлений о реализации генетической патологии в организме. Произошло изменение в понимании причин болезни в сторону генетических, что повлекло за собой изменение места и роли генетики в структуре клинической медицины. Представлены характеристики отдельных специальностей медико-генетической службы: «клинический генетик», «лабораторный генетик», «генетический консультант». Обсуждается изменение контингента семей, обращающихся за медико-генетической помощью. Среди них увеличилась доля лиц без явных клинических проявлений патологии, однако целью обращения в таких случаях была не постановка клинического диагноза, а вопросы будущего здоровья и возможные сроки манифестации заболевания. Это привело к повышению роли генетического консультанта. Рассматриваются этапы появления и становления профессии генетического консультанта, специфика и области работы данного специалиста, тенденции в изменяющихся условиях. Обозначена тенденция перехода от генетического консультирования к геномному консультированию.
The article is devoted to the history of the starting and development of the profession of a genetic consultant. The stages of development of medical genetics and the emergence of genetic counseling are considered. The data accumulated after the completion of the Human Genome Project has led to a more complex understanding of the deployment of genetic pathology in the body. There has been a change in the understanding of the causes of the disease towards genetics, which entailed a change in the place and role of genetics in the structure of clinical medicine. The characteristics of individual specialists of the medical genetic service are presented: clinical geneticist, laboratory geneticist, genetic consultant. The change in the contingent of people seeking medical and genetic help is discussed. Among them, the proportion of people without obvious clinical pathology, whose goal was not to make a clinical diagnosis, but to questions future health, has increased. This has led to an increased role for the genetic counselor. The emergence and formation of the profession of a genetic consultant, the specifics and areas of work of a genetic consultant, trends in changing conditions are considered. The trend of transition from genetic counseling to genomic counseling is indicated.
Prefemin is an Effective Non-Hormonal Treatment of Menstrual Dysfunction
Authors: Грудницкая Е.Н. , Поддубный А.А. , Порфенович Н.В. 
Published: February 2022

В статье проанализированы причины увеличения количества менструальных циклов у современных женщин. Отмечено высокое (до 60%) количество женщин, страдающих от синдрома предменструального напряжения различной степени интенсивности. Описаны уровни регуляции менструального цикла и его нарушения в различные возрастные периоды жизни женщины. Рассматриваются возможности негормональной терапии лекарственным средством Префемин на основе экстракта плодов Vitex agnus castus Zе 440, которое продемонстрировало эффективное дозозависимое влияние на менструальную дисфункцию, предменструальные симптомы и мастодинию.
The article analyzes the reasons for the increase in the number of menstrual cycles in modern women. A high (up to 60%) number of women suffering from premenstrual tension syndrome of varying degrees of intensity was noted. The levels of regulation of the menstrual cycle and its disorders in different age periods of a woman's life are described. The possibilities of non-hormonal therapy with a drug Prefemin based on Vitex agnus castus Ze 440 fruit extract, which has demonstrated an effective dose-dependent effect on menstrual dysfunction, premenstrual symptoms and mastodynia, are considered.
Possibilities of Early Diagnosis of Anthracycline-Induced Cardiomyopathy during Chemotherapy for Breast Cancer
Authors: Снежицкий В.А. , Курбат М.Н. , Карпуть И.А. , Рубинский А.Ю. , Евстрат Е.А. , Смирнова Т.А. 
Published: February 2022

В последние годы отмечается значительное снижение смертности от онкологических заболеваний. Но все больше внимания уделяется негативным последствиям противораковой терапии на сердечно-сосудистую систему. Противоопухолевые антибиотики антрациклины могут вызывать тяжелую систолическую дисфункцию левого желудочка. Клинические исследования и практические наблюдения показали, что антрациклиновая кардиотоксичность носит прогрессирующий и необратимый характер. Таким образом, раннее выявление и профилактика антрациклиновой кардиотоксичности являются новым и весьма важным направлением. Выявление пациентов с высоким риском кардиотоксичности является первым шагом на пути к успешной профилактике сердечной недостаточности у онкологических пациентов. Генетическое типирование может стать эффективной мерой прогнозирования повышенного риска кардиотоксического действия антрациклинов.В обзоре обобщена информация о современных направлениях диагностики антрациклиновой кардиотоксичности и проанализирована роль мутаций генов при развитии сердечной недостаточности, индуцированной химиотерапией.
In recent years, a significant decrease in mortality from oncologic diseases has been observed. But more attention is paid to the negative effects of anticancer therapy on the cardiovascular system. The antitumor antibiotics, anthracyclines, can cause severe LV systolic dysfunction. Clinical studies have shown that anthracycline toxicity is progressive and irreversible. Therefore, early detection and prevention of anthracycline cardiotoxicity has become an important trend. Identification of patients at high risk of cardiotoxicity is the first step towards successful prevention of heart failure in cancer patients. Genetic typing is an effective measure to predict the increased risk of cardiotoxic effects of anthracyclines. The review is concerned modern tendencies in diagnostics of anthracycline cardiotoxicity and analyzes the role of gene mutations in the development of heart failure resulted from chemotherapy induced.
المسؤولية المدنية لرئيس التحرير عن النشر الصحفي الإلكتروني
Authors: عبد المنعم الهام حامد 
Published: February 2022

جاءت هذه الدراسة لتبحث في موضوع المسؤولية المدنية لرئيس التحرير في مجال النشر الصحفي الإلكتروني؛ باعتبار أن مهنة رئيس التحرير تعدُّ من أهم وأخطر المهن في مجال الصحافة، وأنها المهنة الأكثر أهمية بين المهن الأخرى، كما أنها تشكل مقياساً دقيقاً للعمل الصحفي.
تهدف هذه الدراسة إلى بيان مفهوم رئيس التحرير في الموقع الإخباري الإلكتروني، وأساس مسؤوليته المدنية وأركانها وأحكامها، وكذلك إشكالياتها القانونية في ظل القواعد القانونية الواردة في القانون المدني، وبيان مدى ملاءمتها للتطبيق في هذا الشأن.
وتمّ تقسيم الدراسة إلى مبحثين، يتناول المبحث الأول مفهوم وأهمية رئيس التحرير في الصحيفة، ويتناول المبحث الثاني الأحكام الناظمة للمسؤولية المدنية لرئيس التحرير.