bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a harmonized methodology to analyze field side effects of two pesticide products on earthworms at the EU level
Authors: Brulle Franck , Amossé Joël , Bart Sylvain , Conrad Arnaud , Mazerolles Vanessa , Nélieu Sylvie , Lamy Isabelle , Péry Alexandre , Pelosi Céline 
Published: June 2022

Abstract
Before plant protection product (PPP) marketing authorization, a risk assessment for nontarget soil organisms (e.g., earthworms) is required as part of Regulation (EC) No. 1107/2009. Following a stepwise approach, higher tier earthworm field studies are needed if they cannot demonstrate low long-term risk based on laboratory studies. The European guidance for terrestrial ecotoxicology refers to ISO guideline 11268-3 as a standard to conduct earthworm field studies. Assessment of such studies may be challenging, as no European harmonized guidance is available to properly analyze the accuracy, representativeness, and appropriateness of experimental designs, as well as the statistical analysis robustness of results and their scientific reliability. Following the ISO guideline 11268-3, a field study was performed in 2016–2017 (Versailles, France). An assessment of the first year of this field study was performed in agreement with the quality criteria provided in 2006 in the guidance document published by de Jong and collaborators and recommendations by Kula and collaborators that allows describing the protocol and results of earthworm field studies. Not only did we underline the importance of a detailed analysis of raw data on the effects of pesticides on earthworms in field situations, but we also provided recommendations to harmonize protocols for assessing higher tier field studies devoted to earthworms to advance a better assessment of PPP fate and ecotoxicity. In particular, we provided practical field observations related to the study design, pesticide applications, and earthworm sampling. Concurrently, in addition to the conventional earthworm community study, we propose carrying out an assessment of soil function (i.e., organic matter decomposition, soil structuration, etc.) and calculating diversity indices to obtain information about earthworm community dynamics after the application of PPPs. Finally, through field observations, any relevant observation of external and/or internal recovery should be reported. Integr Environ Assess Manag 2023;19:254–271. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
The prevalence of mismatch repair deficiency in ovarian cancer: A systematic review and meta‐analysis
Authors: Atwal Amit , Snowsill Tristan , Dandy Marcus Cabrera , Krum Thomas , Newton Claire , Evans Dafydd Gareth , Crosbie Emma J. , Ryan Neil A. J. 
Published: June 2022

AbstractOvarian cancer (OC) is the least survivable gynecological malignancy and presents late. Five‐year survival for OC is around 45% increasing the need for innovative treatments. Checkpoint inhibitors have shown significant clinical efficacy in mismatch repair deficient (MMRd) cancers and could be a powerful treatment in OC. However, their application in OC is limited due to the lack of data on the prevalence of MMRd. The aim of our study was to conduct a systematic review of the literature and meta‐analysis to provide an accurate estimate of the prevalence of MMRd in OC. We followed PRISMA guidelines throughout. Studies were identified by electronic searches of Medline, Embase, Cochrane CENTRAL and Web of Science followed by citation searching. Studies not written in English were excluded. All studies were reviewed by at least two independent reviewers. Proportions of test positivity were calculated by random and fixed‐effects meta‐analysis models.I2score was used to assess heterogeneity across studies. In total 54 studies were included with 17 532 analyzed for MMRd. The overall proportions of MMRd by immunohistochemistry and microsatellite instability analysis were 6.7% and 10.4%, respectively. MMRd was reported in all histotypes of epithelial OC but was most common in endometrioid OC. We estimate that on average 46.7% (95% CI: 28.8‐65.4) of ovarian carcinomas showing MMRd by IHC had a germline path_MMR variant identified. OC in those with Lynch syndrome seems to present at an earlier age and stage. Studies however were generally of low quality and there was a high degree of heterogeneity. A significant minority (up to 16%) of OC displays MMRd and, therefore, could be amenable to checkpoint inhibition therapy. However, the current literature base is of limited quality and therefore high‐quality prospective studies exploring MMRd in OC with the use of multimodal testing are required. In addition, trials researching efficacy of checkpoint inhibition in MMRd OC are needed.
FOLFIRI plus BEvacizumab or aFLIbercept after FOLFOX‐bevacizumab failure for COlorectal cancer (BEFLICO): An AGEO multicenter study
Authors: Torregrosa Cécile , Pernot Simon , Vaflard Pauline , Perret Audrey , Tournigand Christophe , Randrian Violaine , Doat Solene , Neuzillet Cindy , Moulin Valérie , Stouvenot Morgane , Roth Gael , Darbas Tiffany , Auberger Benjamin , Godet Tiphaine , Jaffrelot Marion , Lambert Aurélien , Dubreuil Olivier , Gluszak Cassandre , Bernard‐Tessier Alice , Turpin Anthony , Palmieri Lola‐Jade , Bouche Olivier , Goujon Gael , Lecomte Thierry , Sefrioui David , Locher Christophe , Grados Lucien , Gignoux Pauline , Trager Stéphanie , Nassif Elise , Saint Angélique , Hammel Pascal , Lecaille Cédric , Bureau Mathilde , Perrier Marine , Botsen Damien , Bourgeois Vincent , Taieb Julien , Auclin Edouard 
Published: June 2022

AbstractAfter failure of first line FOLFOX‐bevacizumab for metastatic colorectal cancer (mCRC), adding either bevacizumab or aflibercept to second‐line FOLFIRI increases survival compared to FOLFIRI alone. In this French retrospective multicentre cohort, we included patients with a mCRC treated with either FOLFIRI‐aflibercept or FOLFIRI‐bevacizumab. The primary endpoint was overall survival (OS), and secondary endpoints were progression‐free survival (PFS), disease control rate (DCR: CR + PR + SD) and safety. We included 681 patients from 36 centers, 326 and 355 in the aflibercept and bevacizumab groups, respectively. Median age was 64.2 years and 45.2% of patients were men. Most patients had RAS‐mutated tumors (80.8%) and synchronous metastases (85.7%). After a median follow up of 31.2 months, median OS was 13.0 months (95% CI: 11.3‐14.7) and 10.4 months (95% CI: 8.8‐11.4) in the bevacizumab and aflibercept groups, respectively (P < .0001). Median PFS was 6.0 months (95% CI: 5.4‐6.5) and 5.1 months (95% CI: 4.3‐5.6) (P < .0001). After adjustment on age, PS, PFS of first line, primary tumor resection, metastasis location and RAS/BRAF status, bevacizumab was still associated with better OS (HR: 0.71, 95% CI: 0.59‐0.86, P = .0003). FOLFIRI‐bevacizumab combination was associated with longer OS and PFS, and a better tolerability, as compared to FOLFIRI‐aflibercept after progression on FOLFOX‐bevacizumab.
A new medical image enhancement algorithm using adaptive parameters
Authors: Dinh Phu‐Hung , Giang Nguyen Long 
Published: June 2022

AbstractThe quality of medical images plays a vital role in many image processing applications such as image segmentation, feature extraction, image classification, image recognition, and image fusion. Some of the common problems with Medical images are noise, blur, or low contrast. According to our observations, current image enhancement algorithms only focus on solving individual problems such as gray level adjustment, noise reduction, or sharpness enhancement. This paper proposes a novel algorithm to solve problems on images simultaneously. First, we propose an image decomposition algorithm. This algorithm allows decomposing the image into three components: structure (IS), texture (IT), and noise (IN). Second, the structural component (IS) is enhanced by the contrast‐limited adaptive histogram equalization method to obtain ICLAHE. We use the structure tensor salient detection operator and the Laplace edge detection operator to add structural and texture features. These operators are applied to the ICLAHE and IT components to obtain the ISTS and ILED components, respectively. The IT and ILED components are used to generate the enhanced component (called ) by using the Max operator. Third, the Marine predators algorithm is used to find the optimal parameters β1, β2, β3, and β4 corresponding to ICLAHE, ISTS, , and IN. Finally, the enhanced image is made up of the sum of the ICLAHE, ISTS, , and IN images multiplied by the optimal parameters β1, β2, β3, and β4, respectively. Six state‐of‐the‐art image enhancement approaches, seven medical image fusion algorithms, and six image quality metrics have been utilized to verify the proposed approach's effectiveness. The experimental results show that the proposed method significantly improves the quality of the input medical images as well as significantly improves the efficiency of current medical image synthesis algorithms.
Optical birefringence changes in myelinated and unmyelinated nerves: A comparative study
Authors: Cury Joaquín , Smets Hugo , Bouzin Caroline , Doguet Pascal , Vanhoestenberghe Anne , Delbeke Jean , Tahry Riëm El , Nonclercq Antoine , Gorza Simon‐Pierre 
Published: June 2022

AbstractThe measurement of birefringence variations related to nerve activity is a promising label‐free technique for sensing compound neural action potentials (CNAPs). While widely applied in crustaceans, little is known about its efficiency on mammal peripheral nerves. In this work, birefringence recordings to detect CNAPs, and Stokes parameters measurements were performed in rat and lobster nerves. While single‐trial detection of nerve activity in crustaceans was achieved successfully, no optical signal was detected in rats, even after extensive signal filtering and averaging. The Stokes parameters showed that a high degree of polarization of light is maintained in lobster sample, whereas an almost complete light depolarization occurs in rat nerve. Our results indicate that depolarization itself is not sufficient to explain the absence of birefringence signals in rats. We hypothesize that this absence comes from the myelin sheets, which constraint the birefringence changes to only take place at the nodes of Ranvier.
Evaluation of Renal Osteodystrophy and Serum Bone-Related Biomarkers in a Peritoneal Dialysis Population
Authors: Pereira Luciano , Magalhães Juliana , Mendonça Luís , Neto Ricardo , Santos Janete , Carvalho Catarina G , Oliveira Ana , Beco Ana , Frazão João 
Published: June 2022

ABSTRACT
The spectrum of renal osteodystrophy (ROD) in peritoneal dialysis (PD) patients remains to be clarified. Ideal intact parathormone (iPTH) levels range is still not defined. The role of sclerostin, dickkopf-related protein 1, osteoprotegerin, and receptor activator for nuclear factor κB ligand for the diagnosis of ROD needs to be elucidated. In this cross-sectional study, tetracycline double-labeled bone biopsy was performed in 49 patients with histomorphometric analysis according Kidney Disease Improving Global Outcomes (KDIGO) guidelines. All patients were treated with biocompatible PD solutions, with calcium concentration of 1.25 mmol/L. Adynamic bone was the most frequent diagnosed pattern (42.9%) followed by hyperparathyroid-related bone disease (28.6%). Twenty-two percent of patients had normal bone. In patients with iPTH within the KDIGO recommended range for dialysis patients, adynamic bone was found in 59% of cases. Median (range) iPTH in patients with adynamic bone was 312 (60–631) pg/mL. Median (range) levels of sclerostin varied from 1511.64 (458.84–6387.70) pg/mL in patients with hyperparathyroid bone disease to 2433.1 (1049.59–11354.52) pg/mL in patients with adynamic bone. Sclerostin/iPTH ratio was the best marker of low turnover disease but iPTH performed best in the diagnosis of high turnover disease. Calcium mass transfer was positive in patients with low bone volume. Adynamic bone is the most frequent ROD pattern in contemporary PD. Our results suggest the need to review the iPTH target range for this population. The sclerostin/iPTH ratio showed improved performance compared to iPTH for the diagnosis of low turnover bone. © 2022 American Society for Bone and Mineral Research (ASBMR).
Five‐FU@CuS/NH2‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells
Authors: Gholami Marjan , Darroudi Majid , Hekmat Azadeh , Khazaei Majid 
Published: June 2022

AbstractIn this study, copper sulfide nanoparticles (CuS‐NPs), which can improve the antiproliferative properties of conventional anticancer drugs such as 5‐fluorouracil (5‐FU), were incorporated into the pores of amine‐functionalized UiO‐66 (CuS/NH2‐UiO‐66). The introduced nano‐drug delivery system was exerted to perform an in vitro treatment on CT‐26 mouse colorectal cancer cells. The synthesized final product was labeled as 5‐FU@CuS/NH2‐UiO‐66 and characterized through conventional methods including X‐ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT‐IR), Brunauer–Emmett–Teller (BET) analysis, Ultraviolet‐Visible (UV‐Vis) analysis, Inductively coupled plasma mass spectrometry (ICP‐MS), and 3‐(4,5‐dimethylthiazol‐2‐yl)−2,5‐diphenyltetrazolium bromide (MTT) assay. In contrast to 5‐FU, the outcomes of the cytotoxicity assay lacked any comparable results for 5‐FU@CuS/NH2‐UiO‐66.
Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis
Authors: Khalaf Hanaa M. , Ahmed Sabreen M. , Welson Nermeen N. , Abdelzaher Walaa Yehia 
Published: June 2022

AbstractThe current study aimed to investigate the potential ameliorative role of Rivastigmine (RIVA), the anti‐Alzheimer drug, against the gastric mucosal injury caused by indomethacin (IND). The rats were divided into four groups: group I was given a vehicle as a control, group II was given RIVA (0.3 mg/kg) once daily intraperitoneal (ip) for 2 weeks, group III was given a single IP dose of 30 mg/kg IND, and group IV was given RIVA ip 2 weeks before the administration of IND. The gastric mucosal injury was detected by the estimation of ulcer index, gastric acidity, pepsin, and mucin concentrations. Malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), total nitrite/nitrate (NOx), and the expression of tumor necrosis factor‐α (TNF‐α), interleukin 6 (IL‐6), nuclear factor kappa B (NF‐κB), Hemoxygenase 1 (HO‐1), and caspase‐3 were all measured in gastric tissue. In addition, histological assessment and proliferating cell nuclear antigen (PCNA) immuno‐expression were studied. Gastric mucosal injury induced by IND was indicated by both biochemical and histopathological assessments. RIVA Pretreatment reduced ulcer index, MDA, TNF‐α, IL‐6, NF‐κB, and caspase‐3 and increased SOD, GSH, NOx, and HO‐1. RIVA improved the suppressed nuclear immunoreaction for PCNA observed with IND. The current findings provide novel evidence that RIVA possesses a prophylactic action against IND‐induced gastric mucosal damage in rats. Despite being a cholinergic drug that is associated with increased pepsin and stomach acidity, RIVA protected against IND‐induced gastric mucosal injury via activating α7nAChR and inhibiting oxidative stress and apoptosis.
Revisiting the Ranson score in acute pancreatitis: Is the drop in hematocrit a worrisome sign?
Authors: Acehan Fatih , Tez Mesut , Kalkan Cagdas , Akdogan Meral , Altiparmak Emin , Doganay Mutlu , Surel Aziz Ahmet , Ates Ihsan 
Published: June 2022

AbstractBackgroundThe Ranson score has 11 parameters that are complex and laborious to implement. In this study, we aimed to create a revised Ranson score by modifying the parameters in Ranson.MethodsA total of 938 patients diagnosed with acute pancreatitis (AP) between 2014 and 2021 were included in the study. The parameters of the Ranson score were included in the univariate and multivariate analyses. According to the results, some of these parameters were modified, and then the revised Ranson score was created.ResultsThe revised Ranson system was created with nine parameters by modifying the hematocrit parameter at 48 hours and excluding the aspartate aminotransferase parameter from the scoring system. For in‐hospital mortality, the area under the curve value of the revised Ranson was 0.959 (95% CI: 0.931–0.986), and it was significantly higher compared to the three scoring systems evaluated. At a cut‐off value of 3.5, the revised Ranson had a sensitivity and specificity of 91.7% and 89.1%, respectively, for mortality.ConclusionThe revised Ranson scoring system had better predictive ability for all clinical outcomes compared to the original Ranson in our large sample of 938 patients. However, the revised version should be further validated by prospective and multicenter studies.
Prognostic Value of Left Atrial Reservoir Strain in Left Ventricular Myocardial Noncompaction: A 3.0 T Cardiac Magnetic Resonance Feature Tracking Study
Authors: Han Pei‐Lun , Shen Meng‐Ting , Jiang Yu , Jiang Ze‐Kun , Li Kang , Yang Zhi‐Gang 
Published: June 2022

BackgroundThe relationship of left atrial (LA) strain to high‐risk heart failure (HF) events in patients with left ventricular myocardial noncompaction (LVNC) remains to be thoroughly investigated.PurposeTo evaluate the LA performance in patients with LVNC, and to investigate the prognostic value of LA phasic strain on high‐risk HF events, and its influencing factors.Study TypeRetrospective.PopulationA total of 95 LVNC patients (74 with LA enlargement [LAE] and 21 without LAE) and 50 healthy controls.Field Strength/sequenceA 3.0 T, balanced steady‐state free‐precession cine imaging.AssessmentLA longitudinal strains were measured by cardiac MRI feature tracking technique. LA volume index (LAVI) and LA ejection fraction (LAEF) were calculated. Their intraobserver and interobserver reproducibility were evaluated. The primary outcome was high‐risk HF events, a composite of first HF hospitalization, hospitalization for worsening HF and death from HF.Statistical TestsStudent's t/Mann–Whitney U, one‐way analysis of variance/Kruskal–Wallis, Chi‐squared, receiver operating characteristic, Kaplan–Meier, log‐rank, Cox regression, Pearson and Spearman correlation and linear regression analyses were performed. The significance threshold was set at P < 0 .05.ResultsLAEF and LA longitudinal strains decreased in LVNC patients irrespective of the presence of LAE. During a median follow‐up of 32.17 months, high‐risk HF occurred in 13 (13.68%) patients. Patients with increased LAVI, decreased LAEF and decreased LA longitudinal strain had significantly higher risks of high‐risk HF events. In patients with LVNC, LA reservoir strain (εs) was independently associated with high‐risk HF (hazard ratio = 23.208 [95% CI: 2.993–179.967]). LV global longitudinal strain (LV GLS) (β = −1.783 [95% CI: −2.493 to −1.073]) was significantly and independently associated with εs. Intraobserver and interobserver reproducibility was excellent for LAVI, LAEF, and LA strain.ConclusionIn patients with LVNC, εs was an independent predictor for high‐risk HF events. LV GLS was an independent determinant of εs in LVNC.Evidence Level4Technical EfficacyStage 4
Continuance in organizational commitment: The role of emotional intelligence, work‐life balance support, and work‐related stress
Authors: Chigeda Felicity , Ndofirepi Takawira Munyaradzi , Steyn Renier 
Published: June 2022

AbstractThe study uses the job demands‐resources (JD‐R) theory to examine the effects of work‐related stress, life‐work balance support, and emotional intelligence on the organizational continuance commitment of workers in under‐resourced organizations. Quantitative cross‐sectional survey data were collected from 212 workers at selected independently owned schools in western Zimbabwe. Correlation and multiple‐regression analyses techniques were used to analyze the data. Positive significant relationships were found between all three independent variables (work‐related stress, work‐life balance support and emotional intelligence) and organizational continuance commitment. Hayes’ PROCESS analyses results demonstrated that emotional intelligence significantly moderated the effect of work‐related stress on organizational continuance commitment, and that of work‐life balance support and organizational continuance commitment. The results highlight the importance of factors including work‐related stress, work‐life balance support, and emotional intelligence in efforts to help inadequately resourced entities retain employees.
Enhanced antioxidant capacity of lipoic acid in different food systems through lipase‐mediated esterification with phytosterols
Authors: He Wen‐Sen , Sun Yuying , Li Zhishuo , Yang Haonan , Li Junjie , Wang Qingzhi , Tan Chen , Zou Bin 
Published: June 2022

AbstractBACKGROUNDα‐Lipoic acid has excellent antioxidant activity, but its poor lipid solubility greatly limits its practical application. This study was undertaken (i) to develop a novel and efficient enzymatic synthesis of lipophilic lipoic acid esters using Candida sp. 99‐125 lipase as a catalyst; and (ii) to systematically evaluate their antioxidant potential against bulk oil, oil‐in‐water emulsion (O/W) and cooked ground meat.RESULTSLipophilic lipoic acid esters were successfully and efficiently synthesized using phytosterols as acyl receptor in the presence of Candida sp. 99‐125 lipase. The product was identified as phytosterol lipoate by mass spectrometry, Fourier transform infrared spectroscopy and nuclear magnetic resonance. The maximum conversion of phytosterol lipoate surpassed 90% within 12 h and its final yield exceeded 81%. Interestingly, the oil solubility of lipoic acid was increased at least 25‐fold and other physicochemical properties were significantly improved. Most importantly, phytosterol lipoate exhibited higher antioxidant activity than lipoic acid in bulk oil, O/W emulsions and cooked ground meat.CONCLUSIONThe antioxidant capacity of lipoic acid can be significantly enhanced by esterification with phytosterols. Therefore, phytosterol lipoate could be further developed as a new antioxidant for use in oil‐ and fat‐based foods. © 2022 Society of Chemical Industry.
Analysis of Thermoplastic Copolymers by Mild Thermal Degradation Coupled to Ion Mobility Mass Spectrometry
Authors: Alawani Nadrah , Barrère‐Mangote Caroline , Wesdemiotis Chrys 
Published: June 2022

AbstractThermal desorption/degradation with an atmospheric solids analysis probe (ASAP) and ion mobility (IM) separation are coupled with mass spectrometry (MS) analysis and tandem mass spectrometry (MS/MS) fragmentation to characterize thermoplastic elastomers. The compounds investigated, which are used in the manufacture of a wide variety of packaging materials, are mainly composed of thermoplastic copolymers, but also contain additional chemicals (“additives”), like antioxidants and UV stabilizers, for enhancement of their properties or protection from degradation. The traditional method for analyzing such complex mixtures is vacuum pyrolysis followed by electron or chemical ionization mass spectrometry, often after gas chromatography separation. Here, an alternative, faster approach, involving mild degradation at atmospheric pressure (ASAP) and subsequent characterization of the desorbates and pyrolyzates by IM‐MS, and if needed, MS/MS is presented. Such multidimensional dispersion considerably simplifies the resulting spectra, permitting the conclusive separation, characterization, and classification of the multicomponent materials examined.