bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic GSK3β-dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia
Authors: Kim Ye Young , Jang Hagoon , Lee Gung , Jeon Yong Geun , Sohn Jee Hyung , Han Ji Seul , Lee Won Taek , Park Jeu , Huh Jin Young , Nahmgoong Hahn , Han Sang Mun , Kim Jeesoo , Pak Minwoo , Kim Sun , Kim Jong-Seo , Kim Jae Bum 
Published: April 2022

<p>Excessive hepatic glucose production (HGP) is a key factor promoting hyperglycemia in diabetes. Hepatic cryptochrome 1 (CRY1) plays an important role in maintaining glucose homeostasis by suppressing forkhead box protein O1 (FOXO1)-mediated HGP. Although downregulation of hepatic CRY1 appears to be associated with increased HGP, the mechanism(s) by which hepatic CRY1 dysregulation confers hyperglycemia in diabetic subjects is largely unknown. In this study, we demonstrate that a reduction in hepatic CRY1 protein is stimulated by elevated E3 ligase F-box and leucine-rich repeat protein 3 (FBXL3)-dependent proteasomal degradation in diabetic mice. In addition, we found that GSK3b-induced CRY1 phosphorylation potentiates FBXL3-dependent CRY1 degradation in the liver. Accordingly, in diabetic mice, GSK3b inhibitors effectively decreased HGP by facilitating the effect of CRY1-mediated FOXO1 degradation on glucose metabolism. Collectively, these data suggest that tight regulation of hepatic CRY1 protein stability is crucial for maintaining systemic glucose homeostasis. </p>
Division of property in case of divorce
Authors: Zhdanyuk K. G. , Polishchuk M.G. 
Published: April 2022

The formalization of a marriage gives rise to new rights and responsibilities for the husband and wife. Today in Ukraine there is a large number of divorces, which, in turn, is a negative phenomenon. This raises problematic issues regarding the distribution of jointly acquired property during the cohabitation of a married couple. It is not always possible for a spouse who has expressed a desire to dissolve a marriage to voluntarily agree on the division of property without being involved in a court case. Litigation over the division of property acquired in marriage is a very popular practice and is often used in real life, as the ex-husband and wife cannot agree among themselves on who will get what property and in what quantity. Therefore, this issue requires detailed and extended study, interpretation and analysis by scientists.
Examine in detail the process of division of jointly acquired property in marriage, provide answers to problematic questions related to joint ownership, analyze controversial situations that often occur in the practice of resolving family disputes over the division of jointly acquired property during marriage.
Thus, the process of division of property between spouses is a complex, laborious and long process that requires awareness of the law. It is also worth noting that there are certain problems in the legal regulation of the division of joint joint ownership, and they require detailed analysis and study by scholars.
With divorce, that is, the termination of marriage relations, both by the legislation of Ukraine and in the regulatory acts and legislation of the EU, personal property of the spouses is not subject to separation. If a man and wife when breaking marriage entered a separate residence mode or one of them went bankrupt, the community of property may be suspended. In addition, according to the legislation of the EU, the allocation of particles in the joint property of his wife and husband can be accomplished in recognizing one of them incapacitated, in case of deprivation of one of them to own certain property, use and dispose of a certain property or inappropriate management of this property.
After divorce, a property relationship arises between a man and a woman, which is the main issue in the study of the peculiarities of family relations after divorce and termination of marriage.
Legal grounds for recognizing a marriage agreement invalid (analysis of judicial practice)
Authors: Mendzhul M. V. , Leta A. V. 
Published: April 2022

The article examines the features of the legal nature and grounds for recognizing a marriage contract as invalid. It has been established that modern family law in Ukraine regulates the institution of a marriage contract in some detail, although it was enshrined in law only in 1992, after amendments to the Marriage and Family Code. First of all, its feature was that it could be concluded only before the official registration of marriage, respectively, came into force from the moment of marriage. In addition, along with the settlement of property relations, the list of which was open, the contract could regulate non-property relations of the spouses. At present, the marriage contract is regulated in more detail by the Family Code of Ukraine and does not provide for the possibility for spouses to establish personal non-property rights in it.
It is established that according to the provisions of Chapter 10 of the Family Code of Ukraine and Articles 203, 215 of the Civil Code of Ukraine, the grounds for invalidating a marriage contract may be as follows: the content of the contract contradicts the legislation of Ukraine and moral principles of society; the will of one or both spouses during the conclusion of the contract is not free and does not correspond to the internal will; the marriage contract is not aimed at the actual occurrence of the legal consequences caused by it.
The analysis of judicial practice allowed us to identify the grounds and features that the courts pay attention to when considering cases of recognition of marriage contracts as invalid, in particular: criteria of legality (legality) of the marriage contract; the content should not contradict the very essence of marriage contracts; the expression of the will of both spouses during the conclusion of the marriage contract must be free and correspond to their inner will; the marriage contract must be aimed at the actual occurrence of the legal consequences caused by it; the marriage contract cannot put one of the spouses in an extremely unfavorable financial position.
It is substantiated that the marriage contract is a bilateral transaction, which has a special subject composition, contains legal restrictions on the subject. The peculiarity of its legal nature is due to the fact that it may give rise to rights and obligations in respect of those family members who are not parties to the contract (for example, in relation to existing or future children). It is proposed to make appropriate changes to Article 103 of the Family Code of Ukraine.
Legal regulation of remote work in Ukraine: current state and prospects of development
Authors: Taran I. O. , Vasechko L. О. 
Published: April 2022

The article is devoted to the remote form of labor organization, identification of problems and prospects for the development of legal regulation of remote employment in Ukraine. The analysis of the national legislation in this sphere is carried out, the advantages and disadvantages of the remote form of employment in modern realities of life are characterized.
It is established that today the remote work market in Ukraine is not as active as in European countries. There are various reasons for this:
- imperfection of legal regulation of the form of remote employment in Ukraine;
- non-adaptation of Ukrainian legislation to international standards;
- Insufficient awareness of the population and employers of Ukraine about the possibility of using remote forms of employment;
- unfinished legislation in matters of registration for remote work, wages, work regimes, social security, payment of taxes;
- uneven degree of development of IT technologies;
- problems of Ukrainians entering the international labor market, complex and contradictory problems of settling international relations in this area due to increasing uneven economic development of the world;
- distrust of virtual agencies and their work outside the legal framework;
- Insufficient level of information and dissemination of new information technologies and non-allocation of a set of information industries in a particular sector of the economy;
- the existence of risks of dubious employers and dishonest employees;
- problems of protection of information and results of work (viruses, hacking, theft of money).
Also, the negative factors of remote employment include a complex psychological aspect, which is that there is a loss of "live" communication with people and the lack of a certain membership in the team of colleagues.
The sphere of remote form of labor organization is not sufficiently regulated at the legislative level.
According to the results of the study, it is concluded that social relations, including social and labor, are developing more and more over time, and therefore need a clear legal regulation. This will make it possible to ensure the organization of remote employment, to determine the general mode of operation, as well as to guarantee and protect the labor rights of the remote worker. In view of this, it should be noted that the legislation of our state at a sufficient level does not regulate the issue of remote employment, it does not meet modern requirements of labor legislation and needs more and more improvement and development.
Francis Bacon’s legislative work
Authors: Gumin O. M. 
Published: April 2022

The article examines the scholarly work of the eminent English thinker, statesman, and lawyer F. Bacon, aimed at improving the existing legislation and legal procedures in England.
The article states that F. Bacon, in all senior State positions, not only showed a constant interest in legal problems, but also took an active part in the implementation of legal acts in the political and legal sphere of the State.
It is stated that F. Bacon has been actively engaged in the elimination of outdated and contradictory laws and regulations and in the creation of new ones that correspond to existing socio-political and economic realities, and also served to strengthen the power of the State and the welfare of its citizens.
The article establishes that F. Bacon, in his academic and theoretical activities, not only acts as a legal theorist, but he actively participates in legislative activities as a member of Parliament in the Lower House, where he has served for many years as its recognized leader.
The thinker actively participates in trials where he acts as a lawyer. He shows great erudition and oratory talent.
It is stated that in the position of Extraordinary Crown Counsel, F. Bacon demonstrates not only high professionalism, but also political wisdom, deep insight into existing socio-political and legal issues, Flexibility in dealing with complex legal problems and the ability to forecast in depth.
It has been established that in his position as Chief Legal Officer, Crown Counsel, F. Bacon has worked intensively and creatively to assemble and draft a single Code of Laws for England. He spent many years codifying English law.
Emphasis was placed on the fact that all of F. Bacon’s theoretical, scientific and political activities were aimed at creating a legal framework that would provide a solid basis for dealing with complex socio-economic, political Moral and ethical problems and other problems, and activities aimed at providing legal support for the development of the economy, industry, agriculture, crafts and trade.
The article emphasizes that F. Bacon creatively and dialectically linked political issues, Economy and law and their implementation in legislation and law-making aimed primarily at strengthening the power and defence capability of the State, especially the active construction of naval and merchant fleets and the expansion of trade relations with other countries.
Bacon has devoted all his talent and energy to building a solid legislative framework as an important factor in solving complex problems of development of society and law.
Theoretical and legal principles of liability for violation of customs rules
Authors: Dopilka V. O. , Pavlovska I. B. 
Published: April 2022

The article examines the legal nature of the concepts of "offense" and "liability" in the context of ensuring compliance with customs legislation, as customs security is the main task of customs authorities of each state, within which they must ensure the receipt of customs duties and other customs payments, to protect the national producer, to prevent the import of banned and dangerous products, to ensure compliance with the law.
In the conditions of insufficient functional capacity of state institutions, high level of corruption and development of criminogenic formations the risks and threats of destabilization of economic security of the state amplify. This leads to aggravation of the socio-economic situation in society, deterioration of the quality of life and the emergence of disparities in spatial and regional development. Strengthening the impact of destabilizing trends on the formation of economic security of the state requires the development of priority areas for its strengthening.
Combating violations of customs rules is a significant, not fully operational, tool to increase the level of economic security of the state. Issues related to the organizational and legal framework for combating violations of customs rules, in particular, the legislative consolidation of responsibility for their commission, are extremely relevant, which led to the research topic. The article counteracts the violation of customs rules is revealed through the essence of administrative and criminal liability for offenses. And it is the scientific study of the legal nature of the concepts of "responsibility" and "offense" using the method of comparing and comparing the definitions of different theorists makes it possible to consider these phenomena with the fullest study of their application to crimes committed in the customs sphere.
The formation and current state of the institution of responsibility for economic crimes is directly related to the formation and development of customs legislation. However, it retains its autonomy in this area, as it clearly defines the law enforcement focus, closely related to those areas of legislation that contain rules whose sanctions should protect legal relations in all spheres and areas of public life, ie. criminal, administrative legislation.
Grounds for reconciliation of the parties in the administrative proceedings of Ukraine
Authors: Slyvka V. V. , Slyvka M. M. 
Published: April 2022

The article is devoted to the study of the grounds for reconciliation of the parties in the administrative proceedings of Ukraine.
It is noted that under the grounds of reconciliation in the administrative proceedings of Ukraine it is advisable to understand a set of mandatory circumstances of the actual reality, the combined presence of which allows to resolve a public law dispute through reconciliation.
It is indicated that in the administrative proceedings of Ukraine there are three groups of grounds for reconciliation of the parties:
– normative – is a system of norms of the current legislation, which regulates various aspects of reconciliation of the parties to a public law dispute;
– actual – the implementation by the parties of a public-law dispute of actions to exercise the right to conciliation on their own initiative or on the basis of a court initiative.
– procedural – these are documents drawn up (submitted, approved, validated) by the parties to a public dispute or by a judge, enabling reconciliation, as a procedure and/or as a desired result of this procedure.
It is emphasized that in addition to the Code of Administrative Procedure of Ukraine as a normative basis for reconciliation should be considered:
1) norms of the Constitution of Ukraine;
2) acts of international law containing standards of human rights, good governance and justice.
3) special legislative acts and by-laws that contain provisions that determine the powers of public service bodies that appear as a party to a public law dispute.
It is emphasized that the procedural grounds for reconciliation in the administrative proceedings of Ukraine include:
1) a petition on the basis of which the court suspends the proceedings in the case for the period of reconciliation. The relevant petition testifies the fact that the parties of the public law dispute reached an agreement on an attempt to reconcile.
2) a statement of reconciliation;
3) a decision approving the terms of reconciliation, which takes place when there are all the conditions (absence of negative conditions), as well as factual and regulatory grounds, after which the proceedings are closed and the parties consider that they have reconciled.
Official authority exceeding by private security agencies employees: foreign experience and prospects for its borrowing
Authors: Syiploki M. V. 
Published: April 2022

The article considers the grounds for criminal liability for exceeding of official authority by employees of private security agencies in the performance of their duties. Emphasis is placed on the peculiarities of considering the issue of liability for harm to life and health of citizens in the implementation of security activities. It is established that in the criminal legislation of Ukraine there is no separate criminal offense which provides liability of security guards for power’ excess at implementation of professional activity.
The foreign experience of the countries in the issue of criminal liability for exceeding the powers by employees of private and public security agencies has been resolved, is analyzed there. The criminal legislation of the Republic of Tajikistan, the Republic of Kazakhstan, the Republic of Moldova, the Kyrgyz Republic, Turkmenistan, Estonia is considered. It is stated that in the criminal legislation of Western Europe and America there are no separate rules on the liability of private security guards or detectives.
It is concluded that it is necessary to criminalize the excess of power by employees of private and public security agencies in the current Criminal Code of Ukraine with the borrowing of foreign experience. It is hoped that the working group on the development of criminal law, which is working on a draft of a new Criminal Code of Ukraine, taking into account the norms of international law, will determine the importance of criminalizing the power excessing by employees of private and public security agencies.
Protection of the Right to Personal Life in the Practice of the European Court of Human Rights and the Constitutional Court of Ukraine
Authors: Stadnyk I. 
Published: April 2022

The central value of constitutionalism is human rights, the process of their protection is one of the most important elements of the legitimization of state power. The article examines the practice of the Constitutional Court, the ECHR on the protection of human rights to private life. The features of the protection of the constitutional right to privacy are highlighted taking into account the fact that the process of constitutional protection of human rights is considered both from a formal point of view through the analysis of specific constitutional norms, and in the context of how real they are, how effective their protection is in everyday legal life.
The article draws the following conclusions. The positions of the Constitutional Court also correspond with the established legal positions of the ECHR regarding the fact that guaranteeing obliges the state not only to proclaim, declare theoretical or illusory rights and freedom, but also to ensure the practicality and effectiveness of rights, the possibility of their implementation. Accordingly, the main objectives of the ECHR are to ensure and develop the ideals and values of a democratic society, to ensure real, practical, effective human rights, respectively, in this con- text of the constitution, the basic laws of European states should first of all express a balanced distribution of powers between the holders of power and their positive and negative responsibilities to ensure human rights.
The ECHR still does not give a clear definition of «private life», deliberately avoiding attempts of this kind, only identifies certain aspects of the concept and prefers (as a rule) focusing on a specific issue. Similarly, the CCU notes the impossibility of defining absolutely all types of behavior of an individual in the spheres of personal life, since personal rights are part of natural human rights, which are not exhaustive.
The article proves that, taking into account the Ukrainian constitutional doctrine, the legal positions of the Con- stitutional Court and the ECHR, firstly, it is advisable to interpret the content of constitutional human rights not through the letter of the law, but through its spirit; consideration of the process of constitutional protection of human rights in the context of reality, practicality and efficiency. Secondly, such an independent method of protection as the termination of an action that violates the right is not sufficient to protect the constitutional right to privacy, the principle of respect for privacy must necessarily include the need for adequate compensation in the event that such violation (interference) occurs arbitrarily or contrary to the law.
The essence of somatic human rights in the process of biomedical research: historiographical principles
Authors: Gromovchuk M. V. , Kozodaev S. P. 
Published: April 2022

It is determined that in order to create a reliable modern scientific foundation for understanding the essence of somatic human rights in the process of biomedical research, a historical digression into the specifics of research of a legal issue of constitutional and legal bases of consolidation of certain somatic rights, selection of certain research priorities and previously existing and current legislation was formed. This will highlight certain trends in the development of both legal doctrine and rule-making activities, the result of which is a radical improvement of current legislation of Ukraine, including codified content, to outline certain issues while clarifying ways to solve them in different historical periods. to avoid negative in the future and borrow positive experiences. Taking into account the historical experience of doctrinal research of certain legal phenomena, scientists say, allows to form a perfect modern scientific basis for improving the constitutional and legal status of a legal institution.
It is pointed out that the history of formation and development of the mechanism of realization and protection of somatic human rights is an integral part of the historical and legal process. The study of positive experiences in this field, which has deep historical roots and is closely linked to socio-economic and political processes, is important for both theory and practice. An integral element of scientific intelligence of any level and direction is a thorough source base, critical analysis and systematization of which is the primary task of a true scientist. This is what makes it possible to carry out objective and impartial research in the field of jurisprudence, as modern scholars emphasize.