bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between sodium and diffusion MRI metrics in multiple sclerosis
Authors: Cipriano Emilio , Boffa Giacomo , Graziano Nicole , Wigley Claire , Petracca Maria , Schiavi Simona , Mancardi Giovanni Luigi , Klineova Sylvia , Boada Fernando , Lublin Fred , Inglese Matilde , Fleysher Lazar 
Published: January 2025

Abstract
Sodium MRI can measure in vivo sodium concentrations in people with multiple sclerosis, but the extent to which these alterations reflect metabolic dysfunction in the absence of tissue damage or neuroaxonal loss remains uncertain. Increases in total sodium concentration and extracellular sodium concentration are believed to be indicative of tissue disruption and extracellular space expansion. Conversely, increase in intracellular sodium concentration may represent early and transient responses to neuronal insult, preceding overt tissue damage. Here, we explored the relationship between total sodium concentration, intracellular sodium concentration and intracellular sodium volume fraction, which reflects extracellular sodium concentration, against histology-validated microstructural metrics obtained using diffusion MRI. Fifty-two individuals with multiple sclerosis and 26 healthy controls underwent 1H/23Na MRI. Microstructural parameters were derived using Diffusion Basis Spectrum Imaging and Neurite Orientation Dispersion and Density-Imaging models. A progressive worsening in total sodium concentration and intracellular sodium volume fraction was observed from HCs white matter to normal-appearing white matter and further into T2-hyperintense and T1-hypointense lesions. Both total sodium concentration and intracellular sodium volume fraction, but not intracellular sodium concentration, correlated with Neurite Orientation Dispersion and Density Imaging and Diffusion Basis Spectrum Imaging metrics within multiple sclerosis lesions. Our findings confirm the utility of total sodium concentration and extracellular sodium concentration as indicators of extracellular expansion and axonal loss and underscore intracellular sodium concentration as a valuable biomarker for metabolic dysfunction in multiple sclerosis.
Study on the resistance characteristics of corrugated flame arrester for hydrogen explosion
Authors: Cao Xingyan , Zhou Xiang , Zhou Jiyuan , Wang Zhenhua , Li Anqi , Bi Sheng , Wei Shanyang , Sun Shaochen , Ding Zhanwu 
Published: January 2025

Abstract
The resistance characteristics of a corrugated flame arrester in hydrogen explosions were investigated using a visual explosion-retardant system. By varying the structural parameters of the corrugated flame-retardant system and the concentration of hydrogen, the flame resistance characteristics and the mechanisms affecting hydrogen explosions were summarized. The results indicate that there was a clear correlation between the flame propagation and pressure rise during explosion resistance. When the flame resistance failed, a significant enhancement effect was observed at the backend of the flame-retardant system. Additionally, a noticeable oscillation occurred in the initial stage of flame propagation due to the obstruction caused by the flame-retardant system. The thickness and porosity of the flame-retardant system, along with the hydrogen concentration, influenced the intensities of shock waves and flames entering the narrow channel, as well as the physical and chemical effects during internal propagation, thereby affecting the overall flame resistance.
Recurrences and rechallenges of suspected drugs in patients with epidermal necrolysis
Authors: Bettuzzi Thomas , Lebrun-Vignes Bénédicte , Assier Haudrey , Pina Vegas Laura , Ingen-Housz-Oro Saskia , Sbidian Emilie 
Published: January 2025

Abstract

Background
Epidermal necrolysis (EN) is a rare and severe condition characterized by diffuse skin and mucosal detachment and mainly induced by drugs. The literature is scarce regarding the rate of recurrences and culprit drug re-exposure.

Objectives
To assess the rate of EN recurrences and to examine re-exposure to high-notoriety drugs in patients with EN.

Methods
We used the French health system database and included all patients with EN. Suspected drugs were assessed at the onset of EN. The primary outcome was the rate of EN recurrence. Secondary outcomes were re-exposure or cross-exposure to high-notoriety drugs (exposure to a drug of the same family) after the acute stage of EN.

Results
In total, 1203 of 1440 patients (83.5%) survived the acute stage, with 27 patients (2.2%, 95% confidence interval 1.5–3.2) meeting the recurrence criteria. In patients with allopurinol as the suspected drug, 10 of 77 (13%) were cross-exposed to febuxostat, without recurrence. Similarly, in patients with carbamazepine or oxcarbazepine as the suspected drug, 2 of 26 (8%) were cross-exposed to lamotrigine, without recurrence. Conversely, 12 of 38 (32%) and 16 of 37 (43%) patients were respectively re-exposed to pantoprazole and esomeprazole when initially suspected, and 12 of 42 (29%) were re-exposed to amoxicillin. Only one recurrence was noted in a patient re-exposed to pantoprazole.

Conclusions
Among patients with EN, the rate of recurrence seems low, contrasting with several re-exposures to beta-lactam antibiotics and proton pump inhibitors when initially suspected. Although we cannot exclude that the suspected drugs were not the responsible ones for several patients, future studies should assess the possible existence of transient risk factors inducing EN.
The potential of autologous patient-derived circulating extracellular vesicles to improve drug delivery in rheumatoid arthritis
Authors: Moskovitch Ori , Anaki Adi , Caller Tal , Gilburd Boris , Segal Ori , Gendelman Omer , Watad Abdulla , Mehrian-Shai Ruty , Mintz Yael , Segev Shlomo , Shoenfeld Yehuda , Popovtzer Rachela , Amital Howard , Halpert Gilad 
Published: January 2025

Abstract
Recognizing the need for innovative therapeutic approaches in the management of autoimmune diseases, our current investigation explores the potential of autologous extracellular vesicles (EVs), derived from the blood of rheumatoid arthritis patients, to serve as therapeutic vectors to improve drug delivery. We found that circulating EVs derived from arthritic mice (collagen-induced arthritis model) express the joint/synovia homing receptor, αVβ3 integrin. Importantly, both autologous labeled EVs, derived from the blood of arthritic mice (collagen antibody-induced arthritis model) and healthy mice-derived EVs, exhibit targeted migration toward inflamed synovia without infiltrating healthy joints, as demonstrated by an in vivo imaging system. Furthermore, EVs derived from plasma of rheumatoid arthritis patients show an overexpression of αV integrin and are effectively taken up by lipopolysaccharides/tumor necrosis factor alpha (TNFα)-induced activated human synovial cell line in vitro, although interestingly the uptake of healthy EVs was found to be significantly increased. Notably, arthritic mice-derived circulating EVs, strongly express murine glucose transporter 1, which in turn can facilitate their binding to glucose-coated gold nanoparticles (previously shown to be conjugated with drugs for improved drug delivery). The significance of our results, lies in the identification of autologous tissue homing EVs as promising vectors, offering a novel avenue to enhance targeted delivery of anti-inflammatory/rheumatic drugs in rheumatoid arthritis treatment.
Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years
Authors: Papenberg Goran , Karalija Nina , Salami Alireza , Johansson Jarkko , Wåhlin Anders , Andersson Micael , Axelsson Jan , Garrett Douglas D , Riklund Katrine , Lindenberger Ulman , Nyberg Lars , Bäckman Lars 
Published: January 2025

Abstract
Although age differences in the dopamine system have been suggested to contribute to age-related cognitive decline based on cross-sectional data, recent large-scale cross-sectional studies reported only weak evidence for a correlation among aging, dopamine receptor availability, and cognition. Regardless, longitudinal data remain essential to make robust statements about dopamine losses as a basis for cognitive aging. We present correlations between changes in D2/3 dopamine receptor availability and changes in working memory measured over 5 yr in healthy, older adults (n = 128, ages 64 to 68 yr at baseline). Greater decline in D2/3 dopamine receptor availability in working memory-relevant regions (caudate, middle frontal cortex, hippocampus) was related to greater decline in working memory performance in individuals who exhibited working memory reductions across time (n = 43; caudate: rs = 0.494; middle frontal cortex: rs = 0.506; hippocampus; rs = 0.423), but not in individuals who maintained performance (n = 41; caudate: rs = 0.052; middle frontal cortex: rs = 0.198; hippocampus; rs = 0.076). The dopamine–working memory link in decliners was not observed in the orbitofrontal cortex, which does not belong to the core working memory network. Our longitudinal analyses support the notion that aging-related changes in the dopamine system contribute to working memory decline in aging.
Differential neurogenic patterns underlie the formation of primary and secondary areas in the developing somatosensory cortex
Authors: Ohte Naoto , Kimura Takayuki , Sekine Rintaro , Yoshizawa Shoko , Furusho Yuta , Sato Daisuke , Nishiyama Chihiro , Hanashima Carina 
Published: January 2025

Abstract
The cerebral cortex consists of hierarchically organized areas interconnected by reciprocal axonal projections. However, the coordination of neurogenesis to optimize neuronal production and wiring between distinct cortical areas remains largely unexplored. The somatosensory cortex plays a crucial role in processing tactile information, with inputs from peripheral sensory receptors relayed through the thalamus to the primary and secondary somatosensory areas. To investigate the dynamics of neurogenesis in cortical circuit formation, we employed temporal genetic fate mapping of glutamatergic neuron cohorts across the somatosensory cortices. Our analysis revealed that neuronal production in the secondary somatosensory cortex (S2) precedes that of the primary somatosensory cortex (S1) from the deep-layer neuron production period and terminates earlier. We further revealed a progressive decline in upper-layer neuron output in S2, attributed to the attenuation of the apical ventricular surface, resulting in a reduced number of upper-layer neurons within S2. These findings support the existence of a protomap mechanism governing the area-specific assembly of primary and secondary areas in the developing neocortex.
Identifying causal neural oscillations underlying working memory
Authors: Mirjalili Mina , Zomorrodi Reza , Daskalakis Zafiris J , Blumberger Daniel M , Hill Sean L , Rajji Tarek K 
Published: January 2025

Abstract
Electroencephalography is instrumental in understanding neurophysiological mechanisms underlying working memory. While numerous studies have associated electroencephalography features to working memory, understanding causal relationships leads to better characterization of the neurophysiological mechanisms that are directly linked to working memory. Personalized causal modeling is a tool to discover these direct links between brain features and working memory performance. Therefore, we applied this approach to electroencephalography data from 66 adult healthy participants collected while performing a 3-back working memory task. Using graphical causal modeling, we discovered causal neural oscillations of working memory performance and compared the causal features between two groups: high and low performers. Total number of causal features in high performers was higher than low performers. Among the causal features, right temporal gamma oscillation was ~5 times (z-score = 3.87, P = 0.0001) more frequently a causal feature among high performers than low performers. However, the power of causal temporal gamma oscillation was not different between the two groups. Our findings suggest that one potential approach to improve working memory performance is to induce more causal gamma oscillations. This can be achieved by generating more local gamma entrainment over the right temporal cortex, rather than simply increasing gamma power.
The microgravity environment affects sensorimotor adaptation and its neural correlates
Authors: Tays G D , Hupfeld K E , McGregor H R , Banker L A , De Dios Y E , Bloomberg J J , Reuter-Lorenz P A , Mulavara A P , Wood S J , Seidler R D 
Published: January 2025

Abstract
The microgravity environment results in transient changes in sensorimotor behavior upon astronauts’ return to Earth; the effects on behavior inflight are less understood. We examined whether adaptation to sensory conflict is disrupted in microgravity, suggesting competition for adaptive resources. We evaluated sensorimotor adaptation pre-, in-, and post-flight, as well as functional brain changes at pre- and post-flight, in astronauts participating in International Space Station missions. Astronauts (n = 13) performed this task pre- and four times post-flight within an MRI scanner and performed the task three times in microgravity during a 6-mo mission. We collected behavioral data from Earth-bound controls (n = 13) along the same timeline. Astronauts displayed no change in adaptation from pre- to inflight or following their return to Earth. They showed greater aftereffects of adaptation inflight; controls did not. Astronauts also displayed increased brain activity from pre- to post-flight. These increases did not return to baseline levels until 90 d post-flight. This pattern of brain activity may reflect compensation, allowing astronauts to maintain pre-flight performance levels. These findings indicate that microgravity does not alter short-term visuomotor adaptation; however, it does affect de-adaptation, and post-flight sensorimotor neural activation can take up to 90 d to return to pre-flight levels.
Technical progress, organisational innovations and labour intensity
Authors: Brondino Gabriel , Gaddi Matteo , Garbellini Nadia 
Published: January 2025

Abstract
The purpose of this article is to discuss the combined effects of Industry 4.0 and lean production in the context of global supply chains on working conditions. Our thesis is that the changes of technique based on integrating Industry 4.0 technologies with lean production incur a substantial cost to labour, manifesting as increased work intensity. In Marxian terminology, they have increased the extraction rate of relative surplus value. Our contribution is closely related to the critical global value chain literature and proposes to contribute to this literature by emphasising the relevance of Industry 4.0 technologies in implementing lean production methods and reinforcing control by head companies over the entire chain. Additionally, it discusses how these dynamics manifest in companies and impact the world of work through surveys conducted with workers. These surveys were carried out in a set of Italian metal-mechanical companies involved in various global chains.
Utilizing thermal imaging drones to investigate sleeping site selection in an arboreal primate
Authors: Gazagne Eva , Goldblatt Chiara , Nguyễn Vỹ Trần , Brotcorne Fany , Hambuckers Alain 
Published: January 2025

Abstract
Sleeping site selection is essential for understanding primate behavioral ecology and survival. Identifying where species sleep helps determine priority areas and critical resources for targeted conservation efforts. However, observing sleeping sites at night is challenging, especially for species sensitive to human disturbance. Thermal infrared imaging (TIR) with drones is increasingly used for detecting and counting primates, yet it has not been utilized to investigate ecological strategies. This study investigates the sleeping site selection of the Critically Endangered black-shanked douc langur (Pygathrix nigripes) in Cát Tiên National Park, Vietnam. Our aim is to assess the feasibility of using a TIR drone to test sleeping site selection strategies in non-nesting primates, specifically examining hypotheses related to predation avoidance and food proximity. Between January and April 2023, we conducted 120 drone flights along 22 transects (~1-km long) and identified 114 sleeping sites via thermal imaging. We established 116 forest structure plots along 29 transects in non-selected sites and 65 plots within douc langur sleeping sites. Our observations reveal that douc langurs selected tall and large trees that may provide protection against predators. Additionally, they selected sleeping sites with increased access to food, such as Afzelia xylocarpa, which serves as a preferred food source during the dry season. These results highlight the effective use of TIR drones for studying douc langur sleeping site selection with minimal disturbance. Besides offering valuable insights into habitat selection and behavioral ecology for conservation, TIR drones hold great promise for the noninvasive and long-term monitoring of large-bodied arboreal species.
Genome-resolved analysis of Serratia marcescens strain SMTT infers niche specialization as a hydrocarbon-degrader
Authors: Ramdass Amanda C , Rampersad Sephra N 
Published: January 2025

Abstract
Bacteria that are chronically exposed to high levels of pollutants demonstrate genomic and corresponding metabolic diversity that complement their strategies for adaptation to hydrocarbon-rich environments. Whole genome sequencing was carried out to infer functional traits of Serratia marcescens strain SMTT recovered from soil contaminated with crude oil. The genome size (Mb) was 5,013,981 with a total gene count of 4,842. Comparative analyses with carefully selected S. marcescens strains, 2 of which are associated with contaminated soil, show conservation of central metabolic pathways in addition to intra-specific genetic diversity and metabolic flexibility. Genome comparisons also indicated an enrichment of genes associated with multidrug resistance and efflux pumps for SMTT. The SMTT genome contained genes that enable the catabolism of aromatic compounds via the protocatechuate para-degradation pathway, in addition to meta-cleavage of catechol (meta-cleavage pathway II); gene enrichment for aromatic compound degradation was markedly higher for SMTT compared to the other S. marcescens strains analysed. Our data presents a valuable genetic inventory for future studies on strains of S. marcescens and provides insights into those genomic features of SMTT with industrial potential.
A new protocolized treatment strategy optimizing medical and surgical care leads to improved healing of Crohn’s perianal fistulas
Authors: De Gregorio Michael , Winata Leon S , Hartley Imogen , Behrenbruch Corina C , Connor Susan J , D‘Souza Basil , Basnayake Chamara , Guerra Glen R , Johnston Michael J , Kamm Michael A , Keck James O , Lust Mark , Niewiadomski Ola , Ong Eugene J S , Schulberg Julien D , Srinivasan Ashish , Sutherland Tom , Woods Rodney J , Wright Emily K , Connell William R , Thompson Alexander J , Ding Nik S 
Published: January 2025

Abstract

Background and Aims
Crohn’s perianal fistula healing rates remain low. We evaluated the efficacy of a protocolized multidisciplinary treatment strategy optimizing care in adults with Crohn’s perianal fistulas.

Methods
A new treatment strategy was established at a single tertiary center. The strategy comprised 3 dynamic stages of care directed toward achieving and maintaining fistula healing. Stage A, active disease, focused on early commencement and proactive escalation of biologic therapies and structured surgical reviews ensuring adequate fistula drainage and conditioning. Stage B, optimized disease with a seton in situ, focused on consideration for seton removal and appropriateness of definitive surgical closure and/or ablative techniques. Stage C, healed disease, focused on proactive care maintenance. Sixty patients were sequentially enrolled and prospectively followed for ≥12 months. Endpoints included clinical healing and radiologic remission in those with clinically active fistulas, and relapse in those with healed fistulas.

Results
At baseline, 52% (n = 31) and 48% (n = 29) had clinically active and healed fistulas, respectively. For patients with clinically active fistulas, 71% achieved clinical healing after 22 months, with estimated healing rates of 39% and 84% at 1 and 2 years, respectively. Radiologic remission was achieved in 25%, significantly higher than baseline inclusion rates of 6%. For patients with healed fistulas, 7% experienced clinical relapse after 23 months, with no significant change in radiologic remission, 80% versus 86% at baseline.

Conclusions
A protocolized treatment strategy proactively optimizing care resulted in high rates of clinical healing and improved radiologic remission of Crohn’s perianal fistulas. Controlled-matched studies are needed.
Modeling time scale of integration in equilibrium passive sampling
Authors: Ghosh Oindrila , Yan Songjing , Bokare Mandar , Ghosh Upal 
Published: January 2025

Abstract
Passive samplers (PSs) deployed in the field for several months provide a time-averaged measurement of the freely dissolved concentration of pollutants, which is important for assessing ecological exposure and estimating pollutant loads. A comprehensive theoretical modeling assessment of the sampling time scale of integration (TSI) of an equilibrium PS is required to correctly interpret the results. We address this knowledge gap by modeling exchange kinetics of polychlorinated biphenyl congeners in low-density polyethylene (PE) PS based on diffusive transport and first-order kinetics. We evaluate the sampling TSI by analyzing the response of the PS to simulated pulsed concentration increases in the water column that lasted for 1 day in a total sampling period of 90 days. More hydrophobic compounds experience slower transfer into the sampler and show a longer TSI compared with less hydrophobic compounds. Similarly, a thick sampler shows longer TSI than a thinner sampler. The sampling TSI for a typical 25.4 μm PE sheet ranged widely from 14–15 days for a dichlorobiphenyl to 43–45 days for a hexachlorobiphenyl. We show that strategic deployment of a thick and thin passive sampler can be used to narrow the range of TSIs for all congeners and used to simultaneously capture episodic events along with long-term averages.