bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astragaloside IV protest against podocyte injury through upregulating mitophagy via Mfn2/ Pink 1/Parkin axis
Authors: Li Yayu , Song Litao , Du Yuanyuan , Jiang Xue 
Published: June 2022

Abstract
Background
Podocyte injury is the most important pathological hallmark of kidney diseases, Autophagy is the critical factors that involve podocyte injury. here we sought to determine whether astragaloside IV (AS-IV) was able to improve renal function and reverse podocyte injury through regulation of autophagy.
Methods
Using Adriamycin (ADR) mice model and cultured immortalized mouse podocytes, were exposed to AS-IV. Western blotting, immunofluorescence and histochemistry were used to analyze markers of autophagy, mitochondrial dysfunction, podocyte apoptosis and glomerulopathy in the progression of focal segmental glomerular sclerosis.
Results
We observed that AS-IV can inhibit podocyte apoptosis, increased reactive oxygen species (ROS) generation, mitochondrial fragmentation and dysfunction through inducing Mitofusin 2(Mfn2)/ PTEN induced putative kinase 1(PINK1)/Parkin mitophagy pathway both in vivo and in vitro. Over-expression of Mfn2 reduced puromycin aminonucleoside (PAN)-induced podocyte injury, while down regulation of Mfn2 expression limited the renal protective effect of AS-IV through regulating mitophagy.
Conclusion
AS-IV ameliorates renal function and renal pathological changes in ADR mice and inhibits PAN-induced podocyte injury by directly enhancing PINK1/Parkin/Mfn2 associated autophagy.
Determinants of Adoption of a Pediatric Weight Management Intervention (PWMI): a Qualitative Study
Authors: Sierra-Velez Desiree , Gundewar Anisha , Persaud Alicia , Simione Meg , Castro Ines , Perkins Meghan , Lindros Jeanne , Salmon Jeremiah , Smith Justin D. , Taveras Elsie M. , Fiechtner Lauren 
Published: June 2022

Abstract
BackgroundChildhood obesity is highly prevalent in the US and disproportionately impacts communities of color and low-income populations; these disparities have worsened during the COVID-19 pandemic. Adoption of effective pediatric weight management interventions (PWMIs) that have been evaluated among low-income diverse populations is needed. The Healthy Weight Clinic PWMI, a package co-developed by the American Academy of Pediatrics and Massachusetts General Hospital, helps health centers establish multidisciplinary Healthy Weight Clinics based on previous randomized controlled trials which demonstrated effectiveness. We sought to identify the determinants to successful adoption of this PWMI and understand adaptations needed prior to implementation in new sites. MethodsWe interviewed 20 stakeholders, 10 from two health centers in Mississippi where the Healthy Weight Clinic PWMI will be piloted (pre-implementation sites) and 10 from health centers that have previously implemented it (sites in maintenance stages). Separate interview guides informed by the Consolidated Framework for Implementation Research (CFIR) were developed for the pre-implementation sites and those in maintenance stages, including questions related to adaptations of the PWMI in response to the COVID-19 pandemic. Qualitative data analysis was conducted using directed content analysis based on CFIR constructs. Adaptations in response to the pandemic were categorized using Framework for Reporting Adaptations and Modifications-Expanded (FRAME).ResultsIn pre-implementation sites, an inner setting facilitator mentioned was a positive learning climate. Characteristics of individuals that can facilitate adoption include staff willingness to learn, valuing evidence-based care for childhood obesity, and culturally and weight-sensitive staff. In terms of patient needs and resources (outer setting), social drivers of health are barriers to adoption, but creative solutions were suggested to mitigate these. Other facilitators related to the intervention included its multidisciplinary model and adaptability. Similar themes were elicited from sites in maintenance stages; adaptations brought on by the pandemic, such as telehealth visits and content modification to align with distancing guidelines and the effects of social isolation were also described.ConclusionUnderstanding the determinants to adoption of an evidence-based PWMI informs necessary adaptations and implementation strategies required to facilitate nationwide dissemination of PWMIs, with the goal of reaching the populations most at-risk.
C/D box small nucleolar RNA SNORD104 promotes endometrial cancer by regulating the 2'-O-methylation of PARP1
Authors: lu bingfeng , Chen Xi , Liu Xin , Chen Jingwen , Qin Honglei , Chen Shuo , Zhao Yang 
Published: June 2022

Abstract
Small nucleolar RNAs (snoRNAs), previously thought to function only as housekeeping genes, are dysregulated in many cancers. However, the snoRNAs’ mechanism in tumors remains unclear. We analyzed the expression profiles of snoRNAs in endometrial cancer tissues in data from The Cancer Genome Atlas, and selected SNORD104 as an upregulated snoRNA in endometrial carcinoma. Antisense oligonucleotide (ASO)‑mediated knockdown of SNORD104 in ISHIKAWA cells significantly inhibited cell proliferation, clone formation, and increased apoptosis, while overexpressed SNORD104 from a plasmid promoted endometrial cancer growth in vivo and in vitro. RIP assays showed that SNORD104 binds the 2'-O-methyltransferase, fibrillarin (FBL). Nm-seq showed that SNORD104 upregulated PARP1 (encoding poly (ADP-ribose) polymerase 1) 2'-O-methylation and protein levels. The RIP assay verified that FBL binds to PARP1 mRNA. Correlation analysis showed that SNORD104 expression is positively correlated with PARP1 expression in endometrial cancer tissues. Actinomycin D and cytoplasmic separation assays showed that SNORD104 increased the stability of PARP1 mRNA and promoted its protein nuclear distribution. Silencing FBL or PARP1 in HEC1B cells overexpressing SNORD104 inhibited cell proliferation and clone formation, and promoted cell apoptosis. Thus, SNORD104 enhances PARP1 mRNA stability and protein level by regulating its 2'‑O‑methylation and promotes the growth of endometrial carcinoma.
Group Recommender Systems for Tourism: How does Personality predicts Preferences for Attractions, Travel Motivations, Preferences and Concerns?
Authors: Alves Patrícia , Martins Helena , Saraiva Pedro , Carneiro João , Novais Paulo , Marreiros Goreti 
Published: June 2022

Abstract
To travel in leisure is an emotional experience, and therefore, the more information about the tourist is known, the more personalized recommendations of places and attractions can be made. But if to provide recommendations to a tourist is complex, to provide them to a group is even more. The emergence of personality computing and personality-aware recommender systems (RS) brought a new solution for the cold-start problem inherent to the conventional RS, and can be the leverage needed to solve conflicting preferences in heterogenous groups and make more precise and personalized recommendations to tourists, as it has been evidenced that personality is strongly related to preferences in many domains, including tourism. Although many studies on psychology of tourism can be found, not many predict the tourists’ preferences based on the Big Five personality dimensions. This work aims to find how personality relates to the choice of a wide range of tourist attractions, travelling motivations, and travel-related preferences and concerns, hoping to provide a solid base for researchers in the tourism RS area to automatically model tourists in the system without the need for tedious configurations, and solve the cold-start problem and conflicting preferences. By performing Exploratory and Confirmatory Factor Analysis on the data gathered from an online questionnaire, sent to Portuguese individuals from different areas of formation and age groups (n = 1035), we found all five personality dimensions can help predict the choice of tourist attractions and travel-related preferences and concerns, and that only Neuroticism and Openness predict travelling motivations.
Case Report the Neoplastic Transformation of Gastric Hyperplastic Polyp in a Context of Autoimmune Gastritis: Improving the Diagnosis
Authors: Xing Yunqi , Han Haixiao , Wang Yuxuan , Sun Zhongmei , Wang Linheng , Peng Dan , Guo Xiaoyuan , Yao Na , Yuan Yali , Zhang Wenji , Mao Tangyou , Liu Yuyue 
Published: June 2022

Abstract
Background: Gastric hyperplastic polyp commonly arises in the abnormal background mucosa, including autoimmune gastritis, also known as type A gastritis. There are no obvious clinical symptoms in the early stages of the disease, which makes it easy to be misdiagnosed and missed, and has a potential risk of malignant transformation over time.Case presentation: In 2020, a 67-year-old woman was admitted for review 6 years after gastric adenoma resection. Upper endoscopy revealed multiple lobulated polyps in the gastric body, which was histologically diagnosed as gastric adenomatous polyp as before. Interestingly, we discovered that the patient had undergone multiple polypectomies at the same part, which was inconsistent with the pathogenesis of adenomatous polyp. Then we did histological examination and revealed that partial epithelial hyperplasia and dysplasia, and the neoplastic areas were interlaced with normal mucosa. We further found that the background diagnosis was autoimmune gastritis. These results supported the diagnosis of neoplastic transformation of gastric hyperplastic polyp, not gastric adenomatous polyp. With the doubt of possible be misdiagnosed, we reviewed the medical history. Retrospective analysis in 2014, 2015 and 2016 confirmed the presence of autoimmune gastritis. Unfortunately, serological tests were not performed and no special treatment was done. Fortunately, the correct diagnosis was eventually confirmed as neoplastic transformation of gastric hyperplastic polyp in a context of autoimmune gastritis in 2020, which enables patients to receive normal treatment and monitoring, and avoids further deterioration of the disease. Conclusions: The purpose of this case report is to increase clinical awareness of neoplastic transformation of gastric hyperplastic polyp in a context of autoimmune gastritis, and hope promise for early diagnosis and treatment.
Circ_0000231 Promotes Paclitaxel Resistance in Ovarian Cancer by Regulating miR-140/RAP1B
Authors: Liu Jiao , Wang Han , Xiao Suqin , Zhang Siyang , Qi Ya , Wang Min 
Published: June 2022

Abstract
Purpose: Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the involvement of circ_0000231 in paclitaxel (PTX) resistant ovarian cancer (OC) remains unclear.Methods: The levels of circ_0000231, microRNA-140 (miR-140) and RAP1B were determined by quantitative real-time PCR (qRT-PCR) or Western blot assay. Cell proliferation, PTX- resistance, apoptosis, migration and invasion were assessed by Cell Counting Kit-8 (CCK-8), flow cytometry and transwell assay. The levels of resistant-related and epithelial–mesenchymal transition (EMT)-related proteins were measured by Western blot assay. Target association between miR-140 and circ_0000231 or RAP1B was demonstrated by dual[1]luciferase reporter assay or RNA Binding Protein Immunoprecipitation (RIP). Biological implications of circ_0000231 in ovarian cancer were implemented in tumor xenograft models.Results: Circ_0000231 and RAP1B levels were increased, while miR-140 level was decreased in PTX-resistant OC tissues and cells. Depletion of circ_0000231 could inhibit resistance, proliferation, invasion, migration and EMT and promoted apoptosis in PTX-resistant OC cells, which was opposited by overexpression of circ_0000231. Circ_0000231 acted as a sponge for miR- 140, and RAP1B was revealed to be target gene of miR-140. Circ_0000231 was a key molecule required for growth, migration, and PTX-resistance and was involved in EMT. Circ_0000231 knockdown increased PTX sensitivity of OC in vivo.Conclusion: Knockdown of circ_000231 suppressed PTX-resistant OC progression via regulating miR-140/RAP1B signaling pathway. Circ_0000231 might play vital roles in the tumorigenesis and chemoresistance of OC.
On the power transform of Gaussian multiplicative chaos
Authors: Wisniewolski Maciej 
Published: June 2022

Abstract
The notion of power transform of Gaussian multiplicative chaos (GMC) is introduced. Two-side estimates on the power and the Laplace transforms of GMC and its inverse respectively are presented. The power and the Laplace transforms are embedded by the functions of (almost) the same order giving the new insight into distributional characterization of GMC in a general setup. A progress towards the Wong's conjecture about the decomposition of continuous part of covariance function is given in case of threshold parameter q > 2.
Synthesis of sulfonic SBA-15 by co-condensation and Soxhlet extraction: optimization by shortening the preparation time
Authors: Tonutti L. G. , Maquirriain M. A. , Querini C. A. , Costa Bruno O. Dalla 
Published: June 2022

Abstract
Propyl sulfonic SBA-15 catalysts are of great interest in several fields of chemistry and have exhibited high activity towards numerous reactions. Nonetheless, the incorporation of these functional groups on SBA-15 silica poses several challenges. Grafting techniques may conduct to a non-uniform dispersion of the functional groups on the surface. Co-condensation of the functional precursor during the synthesis of the silica overcomes this drawback, but requires longer syntheses and it has the disadvantage that removal of surfactant cannot be done by calcination because of the thermal stability of the functional groups present on the surface. Thus, the detemplation is limited in this case to extraction by standard procedures which generally involve large amounts of solvent per gram of catalyst, long contact time and limited yield of the template removal. The aims of this work were, on the one hand, to study the reduction of the ripening time for catalysts prepared by co-condensation with sulfonic groups and, on the other hand, to develop a standard procedure which allows achieving a high yield of detemplation and optimizes the amount of solvent needed and the time required, as well as employ a commercially available solvent. Different characterization techniques allowed to conclude that the obtained materials exhibited high surface area and a good degree of mesoscopic order, comparable with materials obtained by traditional procedures. Also, a high degree of template removal was achieved and the sulfonic groups were preserved in functionalized materials. These results are relevant for a further scale-up of the catalysts production.
The differential expression of the two key genes involved in fructans biosynthetic pathway in artichoke vs wild cardoon improves inulin-type fructans
Authors: Ferrari Michele , De Sio Clara , Muto Antonella , Pagliani Stefania , Bruni Ilaria , Bruno Leonardo , Labra Massimo , Cozza Radiana 
Published: June 2022

Abstract
The artichoke (Cynara cardunculus L. subsp. scolymus Hegi) is an intriguing source of indigestible sugar polymers such as inulin-type fructans. In this study the amount and the quality of inulin-type fructans have been evaluated in the cultivated artichoke (Cynara cardunculus L. subsp. scolymus Hegi) as well as in the wild cardoon (C. cardunculus var. sylvestris L. Fiori). The expression pattern of the genes codifying for the two key enzymes sucrose:sucrose 1-fructosyltransferase (1‐SST) and fructan 1‐fructosyltransferase (1‐FFT), involved in fructans biosynthesis, have been also evaluated both in capitula (heads) and rhizomes. The results showed that the inulin-type fructans were much higher in the heads of the wild cardoon than artichoke, one together with a higher expression of the two key genes fructans codifying enzymes. A conspicuous level of inulin-type fructans was found also in the rhizome, supporting the significant role of these compounds in the storage and in protection from cold and/or winter stress. The results indicate that wild cardoon could be a good and suitable crop for inulin production as well a sustainable agri-food system in Mediterranean marginal areas.
Nucleophilic covalent ligand discovery for the cysteine redoxome
Authors: Fu Ling , Jung Youngeun , Tian Caiping , Ferreira Renan , He FuChu , Yang Jing , Carroll Kate 
Published: June 2022

Abstract
The convergence of reactive cysteine-targeted electrophilic fragments and chemoproteomics have dramatically accelerated the discovery of ligandable sites in the proteome. Our genome encodes 214,000 cysteine residues, at least 20% of which are estimated to be redox-active. Oxidation blunts sulfur reactivity toward electrophiles but opens the door to a new class of nucleophilic covalent ligands that target cysteinyl sulfenic acids, which are widespread post-translational modifications. Here we report a quantitative analysis of nucleophilic fragments screened against the human sulfenome. Ligands were discovered for >500 sulfenated cysteines in >400 proteins, including sites not targeted by electrophiles with the same scaffold. Among these were compounds that preferentially react with hepatoma-derived growth factor (HDGF)-related proteins (HRPs) one of which was able to block nuclear transport of this oncoprotein. Nucleophilic fragments provide a rich resource for chemical biology and drug discovery, where ligandability in the human proteome extends beyond protein thiols.
Lower Limb Response to Anti-personnel Landmine Blast Explosions: Injury Assessment and Mitigation Strategies
Authors: Singh Baljinder , Basri Mohammad Ahmed 
Published: June 2022

Abstract
Injuries in lower extremities due to anti-personnel (AP) landmine blasts have been a major cause of amputation in soldiers. Therefore, it is crucial to understand the mechanism of these injuries for designing advanced personnel protective equipment and superior medical interventions. Various attempts have been made to correlate lower limb cadaveric mine blast test data using surrogate models, but till date, no study has been reported to validate it using numerical methods. In this work, a finite element computational framework was developed for landmine blasts using a biofidelic human body lower limb model for validating in situ tibia forces and injury patterns with PMHS (Post Mortem Human Subjects) test data. Based on the reliability of the validated numerical analysis model, efforts were made to elucidate landmine blast physics, blast wave intensity for various mine threats, pathophysiology of lower extremity trauma, and effectiveness of various blast mitigation strategies. Numerical simulations were performed to assess the level of protection offered by a standard army combat boot to the lower limb for an M-14 mine blast. Furthermore, for attenuating the load transmission to the lower limb, aluminium foam sandwich panel has been proposed as a potential shoe insert material due to its high energy absorption capabilities. Compared to the bare foot scenario, aluminum foam shoe insert in double core configuration was effective in minimizing severity of M-14 mine blast injuries by reducing the peak tibia force by 34% with a significant delay in time of arrival of the peak. Additionally, the proposed mine protective shoe concept offers 25.2% more reduction in peak tibia force compared to the standard military combat boot for a charge triggered by victim’s heel.
On the admissibility and input-output representation for a class of Volterra integro-differential systems
Authors: Bounit Hamid , Tismane Mounir 
Published: June 2022

Abstract
This article studies a class of controlled-observed Volterra integro-differential problems in the case that the operator of the associated Cauchy problem generate a semigroup on a Banach space and the integral part being given by a convolution of integrable functions with Lp-admissible observation operators kernel. Sufficient and/or necessary conditions for Lp-admissibility of control and observation operators are given in term of the kernels. In particular, results on the equivalence between the finite-time (or infinite-time) Lp-admissibility and the uniform Lp-admissibility are given for both control and observation operators, extending a generalization of results known to hold for the standard Cauchy problems. Particular attention is paid to the problem of obtaining the input-output representation of such systems, providing a theory which is analogue to that of Salamon-Weiss for linear systems. We mention that our approach is mainly based on the theory of infinitedimensional Lp-regular linear systems in the Salamon-Weiss sense. These results are illustrated by an example involving heat conduction with memory given by some space fractional Laplacian kernel.
Ultra-light photosensor collars to monitor Arctic lemming activity
Authors: Bolduc David , Fauteux Dominique , Bharucha Éric , Trudeau Jean-Marie , Legagneux Pierre 
Published: June 2022

Abstract
Background
Studying the anti-predatory behavior of mammals represents an important challenge, especially for fossorial small mammals that hide in burrows. In the Arctic, such behaviors are critical to the survival of lemmings considering that predation risks are high every summer. Because detailed information about how lemmings use burrows as hideouts is still lacking, we developed a 1.59 g photosensitive collar to record any event of a small mammal moving between a dark area (e.g. burrow) and a bright area (e.g. outside the burrow). Tests of how collars affected lemming behavior were conducted in captivity in Cambridge Bay, Nunavut, Canada in November 2019 and field tests were conducted on Bylot Island, Nunavut, Canada in August 2021.
Results
The device was made of two chemical batteries and a printed circuit board (PCB) equipped with a photosensor and a real-time clock that recorded amplitude transient thresholds of light (lux) continuously. In accordance with ethical use of such devices, we verified that no abnormal loss of body mass was observed in captive or free-ranging lemmings, and no difference in recapture rates were observed between those with and without a collar. Measurements of light intensities revealed consistent patterns with high lux levels at mid-day and lowest during the night. Lemmings showed clearly defined behavioral patterns alternating between periods outside and inside burrows. Despite 24h daylight in the middle of the summer, August nighttime (i.e. 2300 to 0400) lux levels were insufficient for amplitude transient thresholds to be reached.
Conclusion
By taking advantage of the long periods of daylight in the Arctic, such technology is very promising as it sets new bases for passive recording of behavioral parameters and builds on the prospect of further miniaturization of batteries and PCBs.
Acoustic and Thermoacoustic Jet Propulsion
Authors: Schoenmaker Jeroen , Machado Danilo Almeida , Frandini Heriques , Junior Annibal Hetem , Mota Fábio 
Published: June 2022

Abstract
This manuscript bridges the fields of jet propulsion, synthetic jets and thermoacoustic engines. We put forward the case that acoustic air jets can be considered as a consistent approach for propulsion systems. Hitherto, studies on synthetic jet propulsion have been scattered and rather subsidiary. Furthermore, investigating with the perspective of propulsion can give new insights to the field of synthetic jets, and the physics of propulsion. We developed and characterized the propulsion properties with regard to several relevant parameters such as geometric factors, frequency and intensity of acoustic jets produced electromechanically and thermally. We demonstrated 10.4 mN and 2.7 mN thrust in the acoustic and thermoacoustic modes respectively, using compact tabletop assemblies. The physical mechanism of the jets has been modelled, simulated, verified with Schlieren imaging and laid in the perspective of adherent literature. Similarities and differences with regard to traditional jet propulsion systems are discussed. As an essentially unexplored avenue, several improvement directions are indicated.