bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities ofKRASMutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Son Jieun , Okoro Jeffrey J. , Mira Alessia , Patrucco Enrico , Eum Yoonji , Wang Xinan , Paranal Raymond , Wang Haiyun , Lin Mika , Haikala Heidi M. , Li Jiaqi , Xu Yue , Alessi Joao Victor , Chhoeu Chhayheng , Redig Amanda J. , Köhler Jens , Dholakia Kshiti H. , Chen Yunhan , Richard Elodie , Nokin Marie-Julie , Santamaria David , Gokhale Prafulla C. , Awad Mark M. , Jänne Pasi A. , Ambrogio Chiara 
Published: January 2022

AbstractPurpose:Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly heterogeneous, and data on the potential isoform-dependent therapeutic vulnerabilities are still lacking.Experimental Design:We developed an isogenic cell-based platform to compare the oncogenic properties and specific therapeutic actionability of KRAS-mutant isoforms. In parallel, we analyzed clinicopathologic and genomic data from 3,560 patients with non–small cell lung cancer (NSCLC) to survey allele-specific features associated with oncogenic KRAS mutations.Results:In isogenic cell lines expressing different mutant KRAS isoforms, we identified isoform-specific biochemical, biological, and oncogenic properties both in vitro and in vivo. These exclusive features correlated with different therapeutic responses to MEK inhibitors, with KRAS G12C and Q61H mutants being more sensitive compared with other isoforms. In vivo, combined KRAS G12C and MEK inhibition was more effective than either drug alone. Among patients with NSCLCs that underwent comprehensive tumor genomic profiling, STK11 and ATM mutations were significantly enriched among tumors harboring KRAS G12C, G12A, and G12V mutations. KEAP1 mutation was significantly enriched among KRAS G12C and KRAS G13X LUADs. KRAS G13X-mutated tumors had the highest frequency of concurrent STK11 and KEAP1 mutations. Transcriptomic profiling revealed unique patterns of gene expression in each KRAS isoform, compared with KRAS wild-type tumors.Conclusions:This study demonstrates that KRAS isoforms are highly heterogeneous in terms of concurrent genomic alterations and gene-expression profiles, and that stratification based on KRAS alleles should be considered in the design of future clinical trials.
Implantable Cardioverter Defibrillators in Infants and Toddlers: Indications, Placement, Programming, and Outcomes
Authors: Zahedivash Aydin , Hanisch Debra , Dubin Anne M. , Trela Anthony , Chubb Henry , Motonaga Kara S. , Goodyer William Rowland , Maeda Katsuhide , Reinhartz Olaf , Ma Michael , Martin Elisabeth , Ceresnak Scott R. 
Published: January 2022

Background:
Limited data exist regarding implantable cardioverter defibrillator (ICD) usage in infants and toddlers. This study evaluates ICD placement indications, procedural techniques, programming strategies, and outcomes of ICDs in infants and toddlers.

Methods:
This is a single-center retrospective review of all patients ≤3 years old who received an ICD from 2009 to 2021.

Results:
Fifteen patients received an ICD at an age of 1.2 years (interquartile range [IQR], 0.1–2.4; 12 [80%] women; weight, 8.2 kg [IQR, 4.2–12.6]) and were followed for a median of 4.28 years (IQR, 1.40–5.53) or 64.2 patient-years. ICDs were placed for secondary prevention in 12 patients (80%). Diagnoses included 8 long-QT syndromes (53%), 4 idiopathic ventricular tachycardias/ventricular fibrillations (VFs; 27%), 1 recurrent ventricular tachycardia with cardiomyopathy (7%), 1 VF with left ventricular noncompaction (7%), and 1 catecholaminergic polymorphic ventricular tachycardia (7%). All implants were epicardial, with a coil in the pericardial space. Intraoperative defibrillation safety testing was attempted in 11 patients (73%), with VF induced in 8 (53%). Successful restoration of sinus rhythm was achieved in all tested patients with a median of 9 (IQR, 7.3–11.3) J or 0.90 (IQR, 0.68–1.04) J/kg. Complications consisted of 1 postoperative chylothorax and 3 episodes of feeding intolerance. VF detection was programmed to 250 (IQR, 240–250) ms with first shock delivering 10 (IQR, 5–15) J or 1.1 (IQR, 0.8–1.4) J/kg. Three patients (20%) received appropriate shocks for ventricular tachycardia/VF. No patient received an inappropriate shock. There were 2 (13%) ventricular lead fractures (at 2.6 and 4.2 years post-implant), 1 (7%) pocket-site infection, and 2 (13%) generator exchanges. All patients were alive, and 1 patient (7%) received a heart transplant.

Conclusions:
ICDs can be safely and effectively placed for sudden death prevention in infants and toddlers with good midterm outcomes.
FeTaQA: Free-form Table Question Answering
Authors: Nan Linyong , Hsieh Chiachun , Mao Ziming , Lin Xi Victoria , Verma Neha , Zhang Rui , Kryściński Wojciech , Schoelkopf Hailey , Kong Riley , Tang Xiangru , Mutuma Mutethia , Rosand Ben , Trindade Isabel , Bandaru Renusree , Cunningham Jacob , Xiong Caiming , Radev Dragomir , Radev Dragomir 
Published: January 2022

AbstractExisting table question answering datasets contain abundant factual questions that primarily evaluate a QA system’s comprehension of query and tabular data. However, restricted by their short-form answers, these datasets fail to include question–answer interactions that represent more advanced and naturally occurring information needs: questions that ask for reasoning and integration of information pieces retrieved from a structured knowledge source. To complement the existing datasets and to reveal the challenging nature of the table-based question answering task, we introduce FeTaQA, a new dataset with 10K Wikipedia-based {table, question, free-form answer, supporting table cells} pairs. FeTaQA is collected from noteworthy descriptions of Wikipedia tables that contain information people tend to seek; generation of these descriptions requires advanced processing that humans perform on a daily basis: Understand the question and table, retrieve, integrate, infer, and conduct text planning and surface realization to generate an answer. We provide two benchmark methods for the proposed task: a pipeline method based on semantic parsing-based QA systems and an end-to-end method based on large pretrained text generation models, and show that FeTaQA poses a challenge for both methods.
‘Religious Literacy’: Some Considerations and Reservations
Authors: Wolfart Johannes C. 
Published: January 2022

Abstract
In recent years “religious literacy” advocacy has gained a significant following, both academic and non-academic. Furthermore, it is widely accepted that attainment of religious literacy (and the reduction of religious illiteracy – ignorance about religions, either explicitly or by implication) will bring social benefits or cure societal ills. Yet, the term “religious literacy” itself remains poorly defined; neither have the benefits touted by advocates of “religious literacy” been subjected to empirical testing. Instead, reasons for the ready adoption of the term can be found in its particular genealogy, and in its relation to advocacies for other “literacies”. Moreover, especially the advocacy of basic literacy (i.e., of literacy, literally speaking) is historically entangled with Christian theologies and other ideologies, a history giving rise to what Harvey Graff once called the “literacy myth” linking increased literacy to social improvements or progress. Thus, finally, the particular resonance of “religious literacy” in Religious Studies and related academic circles may reflect the inescapable historical character of our particular academic enterprise as “ex-theological.”
Ripeness Theory in the Digital Age: When to Log Off from Cyber Conflict
Authors: Polk Alexandria 
Published: January 2022

Abstract
When are cyber conflicts ripe for negotiation? Analysis of cyber conflict presents a challenge to the prevailing negotiation concept, Zartman’s ripeness theory. Ripeness theory posits that the timing of a negotiation stems from the conflicting parties’ perception of a “mutually hurting stalemate” (MHS) and “a way out” of conflict through dialogue. While this theory has shown merit for negotiations related to conventional warfare or economic disputes, there are gaps in its applicability for resolving cyber conflict. Specifically, the concept of a “hurting stalemate” has little to no presence in cyber disputes, rendering MHS incompatible with pure cyber negotiations. As such, redefining mutually hurting stalemate for cyber conflict is paramount to address this discrepancy. Examining the 2015 bilateral US-China Cybersecurity Agreement provides a context for applying our hypothesis and demonstrates how accepted negotiation theory may be applied to cyber conflict.
Rediscovery and IUCN threat assessment of Themeda saxicola (Poaceae: Andropogoneae), an endemic grass from the Eastern Ghats, India
Authors: CHORGHE ALOK R. , KULLOLI R.N. 
Published: January 2022

Themeda saxicola is an endemic perennial grass rediscovered after laps of 67 years from the Raisili hill (type locality) and Deomali hill, from the Eastern Ghats in the Koraput district of Odisha. The detailed description along with colour photographs of the habitats, habit and floral parts are provided for easy identification of the species. In addition, distribution map and IUCN threat category assessment are also provided.
A new bent-toed gecko (Cyrtodactylus Gray: Squamata: Gekkonidae) from the state of Mizoram, India
Authors: LALREMSANGA HMAR TLAWMTE , CHINLIANSIAMA HAUZEL , BOHRA SANATH CHANDRA , BIAKZUALA LAL , VABEIRYUREILAI MATHIPI , MUANSANGA LAL , MALSAWMDAWNGLIANA FANAI , HMAR GOSPEL ZOTHANMAWIA , DECEMSON H.T. , SIAMMAWII VANLAL , DAS MADHURIMA , PURKAYASTHA JAYADITYA 
Published: January 2022

Herein we describe a new species of Cyrtodactylus from Lunglei District in the state of Mizoram, India. Based on morphology and ND2 gene sequences, the species was found to be a member of the Cyrtodactylus khasiensis group. The species can be identified by its moderate size (adult SVL 64.9–75.1 mm) with rounded, bluntly conical and feebly keeled dorsal tubercles in 24–28 longitudinal rows; 32–40 paravertebral tubercles between the level of the axilla and the level of the groin; 37–43 mid-ventral scale rows; 3–5 precloacal pores in males and 5–7 pitted precloacal scales in females; 16–18 subdigital lamellae under IV toe; no single row of transversely enlarged subcaudal scales; dorsal markings are dark brown, irregular and distinct; tail with alternating dark and light bands.
The Catholic-National Cauldron
Authors: Macocha Dominika 
Published: January 2022

This letter is a response by Dominika Macocha to the discussion between Elżbieta Janicka, Konrad Matyjaszek, Xawery Stańczyk, Katrin Stoll and Anna Zawadzka about her video-sculptural installation work “50°31’29.7”N 22°46’39.1”E, 50°30’56.2”N 22°46’01.0”E, 50°30’41.0”N 22°45’49.5”E” published in Studia Litteraria et Historica 9 (2020). The discussion has enabled the artist to look at her work from a new perspective, to reflect on it in a critical way and to clarify central issues raised by the discussants. The letter is a testimony to the artist’s engagement with the local community which until today lives in the shadow of those Poles who, on their own initiative, murdered Jews during the Shoah. Macocha reveals the current efforts undertaken by several actors, among them the community of Bilgoraj, to cover up the historical fact of the murder of Jews carried out by members of the local population. The letter closes with a reflection on the responsibility of the artist in view of the fact that a revolution of the symbolic system has not yet occurred.
Satellite-Based Characterization of Convection and Impacts from the Catastrophic 10 August 2020 Midwest U.S. Derecho
Authors: Bell Jordan R. , Bedka Kristopher M. , Schultz Christopher J. , Molthan Andrew L. , Bang Sarah D. , Glisan Justin , Ford Trent , Lincoln W. Scott , Schultz Lori A. , Melancon Alexander M. , Wisinski Emily F. , Itterly Kyle , Homeyer Cameron R. , Cecil Daniel J. , Cogil Craig , Donavon Rodney , Lenning Eric , Wolf Ray 
Published: January 2022

Abstract
The catastrophic derecho that occurred on 10 August 2020 across the midwestern United States caused billions of dollars of damage to both urban and rural infrastructure as well as agricultural crops, most notably across the state of Iowa. This paper documents the complex evolution of the derecho through the use of low-Earth-orbit passive-microwave imager and GOES-16 satellite-derived products complemented by products derived from NEXRAD weather radar observations. Additional satellite sensors including optical imagers and synthetic aperture radar (SAR) were used to observe impacts to the power grid and agriculture in Iowa. SAR improved the identification and quantification of damaged corn and soybeans, as compared to true-color composites and normalized difference vegetation index (NDVI). A statistical approach to identify damaged corn and soybean crops from SAR was created with estimates of 1.97 million acres of damaged corn and 1.40 million acres of damaged soybeans in the state of Iowa. The damage estimates generated by this study were comparable to estimates produced by others after the derecho, including two commercial agricultural companies.
Exceptional Warmth in the Northern Hemisphere during January–March of 2020: The Roles of Unforced and Forced Modes of Atmospheric Variability
Authors: Schubert Siegfried D. , Chang Yehui , DeAngelis Anthony M. , Koster Randal D. , Lim Young-Kwon , Wang Hailan 
Published: January 2022

AbstractMuch of northern Eurasia experienced record high temperatures during the first three months of 2020, and the eastern United States experienced a significant heat wave during March. In this study, we show that the above episodes of extraordinary warmth reflect to a large extent the unusual persistence and large amplitude of three well-known modes of atmospheric variability: the Arctic Oscillation (AO), the North Atlantic Oscillation (NAO), and the Pacific–North American (PNA) pattern. We employ a “replay” approach in which simulations with the NASA GEOS AGCM are constrained to remain close to MERRA-2 over specified regions of the globe in order to identify the underlying forcings and regions that acted to maintain these modes well beyond their typical submonthly time scales. We show that an extreme positive AO played a major role in the surface warming over Eurasia, with forcing from the tropical Pacific and Indian Ocean regions acting to maintain its positive phase. Forcing from the tropical Indian Ocean and Atlantic regions produced positive NAO-like responses, contributing to the warming over eastern North America and Europe. The strong heat wave that developed over eastern North America during March was primarily associated with an extreme negative PNA that developed as an instability of the North Pacific jet, with tropical forcing providing support for a prolonged negative phase. A diagnosis of the zonally symmetric circulation shows that the above extratropical surface warming occurred underneath a deep layer of tropospheric warming, driven by stationary eddy-induced changes in the mean meridional circulation.
Predictive Value of Complete Blood Count-Derived Inflammatory Markers for 5-Year Survival After Carotid Endarterectomy: Implications for Practice
Authors: Casanova Núria , Diaz-Duran Carles , Nieto Lluís , Llort Carme , Elosua Roberto , Clara Albert 
Published: January 2022

Complete blood count inflammatory markers (CBC-IMs) have been associated with cardiovascular diseases and mortality. We aimed to evaluate the relationship between preoperative CBC-IMs and 5-year survival after carotid endarterectomy (CEA). Retrospective analysis of 411 consecutive patients who underwent CEA between 2004 and 2018 was done. CBC-IM included the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte (LMR) ratio, and systemic immune-inflammation index (SII). Survival rate at 5 years was 79.8%. Age (hazard ratio (HR) = 1.05, P = .003), hemoglobin (HR = 0.78, P < .001), heart failure (HR = 2.91, P = .005), American Society of Anesthesiologists (ASA)-IV score (HR = 2.41, P = .043), and active neoplastic disease (HR = 2.61, P = .028) were independently related to survival. The discrimination of this model (C-statistic) was 0.698. Spline analysis showed a linear relationship between survival and NLR ( P < .001), PLR ( P < .001), and SII ( P < .001). After adjusting for the baseline predictive score, there was a significant relationship between survival and NLR (HR = 1.191, P = .001), PLR (HR = 1.004, P = .017), and SII (HR = 1.001, P < .001). The addition of NLR, PLR, and SII to the survival model improved the continuous net reclassification index (c-NRI) by 0.29 ( P = .028), 0.347 ( P = .008), and 0.481 ( P < .001), respectively, but not the C-statistic. CBC-IMs show a linear and independent relationship with 5-year survival after CEA and may moderately contribute to patient selection for this preventive intervention.
A Closer Look at Warning Cues on the Sustained Attention to Response Task Performance
Authors: Dang Jasmine A. , Shaw Tyler H. , McKnight Patrick E. , Helton William S. 
Published: January 2022

Objectives We investigated the effects of auditory cues of varying reliability levels on response inhibition performance using a target detection task to determine if external cues offer performance benefits. Further, we examined how the slope of the speed accuracy trade-off changes as a function of auditory cue reliability and used the trade-off to understand where any performance gains may be realized. Background Researchers have proposed that the sustained attention to response task (SART) can be used to study the mechanisms causing failures of response inhibition. External cues may mitigate the results of motor inhibition failure. The extent to which external cues can effectively aid performance depends on the level of cue reliability. Method Ninety-one participants performed three SARTs with auditory cue assistance at three different levels of reliability (i.e. 0%, 60% and 100% reliable at cueing imminent No-Go stimuli). Results We observed fewer errors of commission and faster reaction time in conditions with higher cue reliability. The slope of speed-accuracy trade-off relationship was impacted by cue reliability and was not a simple linear function. Conclusion Reliable auditory cues aid performance by reducing reaction time and errors of commission. Auditory cues also impact the relationship between speed and accuracy trade-off. Application Insights of cue effectiveness at different reliability levels help people make informed decisions in developing automation interfaces or sensors based on expected performance. Reliable cues mitigate the risk of impulsive errors; however, the reliability has to be high to have a noticeable impact on the speed-accuracy trade-off.
Perceptual Responses and Future Exercise Intentions of Individuals With Systemic Arterial Hypertension
Authors: Moreira Mirelle Vieira , Neves Victor Ribeiro , Schwingel Paulo Adriano , Moreira Sergio Rodrigues 
Published: January 2022

To analyze the perceptual responses and future intentions (FI) to engage in continuous moderate aerobic exercise (CE) and high-intensity interval exercise (HIIE) of individuals with systemic arterial hypertension (SAH), we had 25 participants with SAH ( M age = 48.0, SD = 8.0 years) perform, on different days and in randomized order, 33 minute sessions of CE and 30 minutes of HIIE. Twenty seconds after each 3-minutes of these sessions, we obtained participant responses to Ratings of Perceived Exertion (RPE), the Feeling Scale (FS), the Felt Arousal Scale (FAS), and attentional focus (AF). We assessed their FI to engage in CE and HIIE at the end of each session. We analyzed results using two-way ANOVAs with repeated measures, Spearman correlation coefficients, a simple linear regression, and Wilcoxon test. We found a significant time by session type (CE and HIIE) interaction effect for RPE ( p < .001), FAS ( p = .002), and AF ( p = .004). Participants’ FI to engage in HIIE were only significantly correlated with FAS ( r = −.424; p = .035) and AF ( r = .431 ; p = .032) responses. FAS responses (βz = −.455; R2 = .207 ; p = .022) and AF responses (βz = .467; R2 = .218; p = .019) predicted FI for engaging in HIIE. There were no significant differences in participants’ FI to engage in CE sessions ( M = 76.4, SD =22.5%) versus HIIE sessions ( M = 71.8, SD = 22.9%; p = .177). Individuals with SAH had more positive perceptions of CE than HIIE, as seen by their greater dissociative AF in the CE sessions. Furthermore, these results supported the application of strategies aimed at manipulating AF in this population, possibly as a tool to increase participants’ FI to engage in subsequent physical exercise.
Parental warmth may not always be beneficial: High parental warmth impairs victimized adolescents’ academic achievement via elevated school burnout
Authors: Li Caina , Tan Xulan , Zhao Qingling , Ren Ping 
Published: January 2022

Although research has documented the adverse effect of peer victimization on academic achievement, little is known about the underlying mechanism. This three-wave longitudinal study attempts to examine whether school burnout would explain the influence of peer victimization on academic achievement and whether this undesirable effect would be conditional on parental warmth using a sample of 706 Chinese adolescents (54.77% boys; Mage = 12.72 years, SD = 0.40 at baseline). Both self-reported and peer-nominated victimization, school burnout, and parental warmth were assessed at baseline, and school burnout was measured 1 year later. Their academic achievement was collected from school records at baseline and 2 years later. The results revealed that self-reported (rather than peer-nominated) victimization at baseline impaired students’ academic achievement 2 years later through increasing their school burnout. Interestingly, higher parental warmth aggravated, rather than alleviated this indirect effect. These findings support the Reverse Stress-Buffering Model and the Ecological Systems Theory highlighting the importance of considering multiple interpersonal relationships simultaneously to heighten adolescent academic performance.
Maternal experiences of childhood psychological maltreatment: Relations with toddler emotional regulation
Authors: Aviles Ashleigh I. , Reisz Samantha , Jacobvitz Deborah , Hazen Nancy 
Published: January 2022

Childhood psychological maltreatment is a prevalent type of maltreatment, but one that is less studied compared to other forms of abuse. The intergenerational effects of psychological maltreatment have yet to be fully explored. This study examined mothers’ recollections of childhood experiences of psychological maltreatment, assessed prenatally, and in relation to their own and their toddler’s emotion regulation. Psychological maltreatment was assessed through a new coding system created for use with Adult Attachment Interviews (AAIs). Using structural equation modeling, we examined the direct effects of mothers’ accounts of psychological and physical maltreatment during childhood on mothers’ emotion dysregulation in a caregiving context and their toddlers’ observed emotional dysregulation. Participants were 125 mother–toddler dyads in central Texas ( Mage = 29.9 years). Mothers completed AAIs prenatally; toddlers completed frustration tasks to assess underregulation at 24 months of age. Maternal experiences of psychological maltreatment, but not physical maltreatment, were related to maternal emotion dysregulation during parenting and their children’s emotional underregulation. Mother and child emotional dysregulation were also related. The effects of mothers’ childhood experiences of psychological maltreatment have specific intergenerational consequences and must be explored separately from their experiences of physical maltreatment.