bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and evaluation of a functional effervescent powder based on inclusion complexes of orange oil and β-cyclodextrin derivatives
Authors: Fadel Hoda , Lotfy Shereen , El-Aleem Fatma Abd , Ahmed Mohamad Sayed , Asfour Marwa , Taleb Sally Abou , Saad Rasha 
Published: November 2022

Abstract
Flavoured functional effervescent powders are becoming increasingly popular by consumers due to their health benefits and easy dissolution. In present study, orange flavoured effervescent powders having functional properties were prepared. Orange oil (O) was blended with different essential oils (EOs) having high antioxidant activity. The orange oil and the O-EOs blends were subjected to gas chromatography-mass spectrometry (GC-MS) analysis and evaluation of radical scavenging activity. Combinations of two water soluble β-cyclodextrine polymers, 2-hydroxypropyl-β-cyclodextrine (2-HP-β-CD) and epihydrin-β-cyclodextrin (EPI-β-CD) were prepared at different molar ratios (3: 1 and 1: 3, F1 and F2, respectively). The O-EOs blends that showed the highest antioxidant activities and best odour qualities were encapsulated with F1 and F2, separately. The orange flavoured inclusion complexes were prepared by freeze drying method. The particle sizes of the inclusion complex powders were in the nanoscale. Characterization of the inclusion complexes nanoparticles were performed by scanning electron microscopy (SEM), Fourier transform infrared microscopy (FT-IR). The results confirmed the successful formation of the inclusion complexes. However, inclusion complex of O-EOs blend with F1 (O-F1C-IC) showed the smallest particle size (113.9 ± 15.9 nm), the more negative zeta potential (-27.1 ± 1.27 mV), the highest encapsulation efficiency (95.51%) and best odour quality. Therefore, it was mixed with an effervescent powder having high acceptable characteristics. The orange flavoured effervescent powder showed superior flowability.
Fabrication and Evaluation of Biodegradable Alginate Bead Controlled Release Fertilizer for the Controlled Release on Nitrogen
Authors: Hwang Dong Ki , Cho Ha Young , Thanh Truong Vu , Kim Hyeri , Kim Hyo Jeong , Jeon Hyeonyeol , Oh Dongyeop X. , Park Jeyoung , Koo Jun Mo 
Published: November 2022

AbstractControlled-release fertilizers (CRFs) are a next-generation type of fertilizers, with several advantages over conventional fertilizer. However, using non-degradable and petroleum-based materials in the fabrication of CRFs possess considerable threat to agricultural soils and the environment. Therefore, this study aimed to develop a highly biodegradable, nontoxic, and biocompatible CRFs based on calcium alginate (CaAlg) beads. The results showed that the sphericity of the beads increased with decreasing CaCl2concentration and increasing gelation time. Additionally, there was a significant decrease in the viscosity of sodium alginate (NaAlg) suspension with increasing concentration of urea. Moreover, there was an increase in the urea loading (UL) efficiency and a decrease in the urea release rate of the beads with increasing concentration of CaCl2. Furthermore, carrots grown in the control soil and soil containing urea were larger compared with those grown in soils containing CRF, indicating the controlled release of nitrogen by the CRF. Adding humic acid (HA), poly vinyl acid (PVA), and citric acid to the suspension increased the stability and improved the urea release profile of the CRF. Overall, the fabrication process is easy and could be applied for the mass production of CRFs.
Anemia in patients with hidradenitis suppurativa
Authors: Revankar Rishab , Rojas Mary , Walsh Samantha , Patel Heli , Revankar Nikita , Han Joseph , Parameswaran Anupama 
Published: November 2022

Abstract
IMPORTANCE
Hidradenitis suppurativa (HS) is associated with a number of physical and psychological comorbidities. Studies have suggested an association between HS and anemia; however, this association is not widely understood and may result in delayed diagnosis and treatment and possible increase in morbidity and mortality.
OBJECTIVE
To systematically review and perform a metanalysis regarding the association between HS and anemia, and to characterize the subtypes of anemia associated with HS.
DATA SOURCES
A search of the EMBASE, Medline, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials databases from the time of database inception to September 25, 2022, yielded 313 unique articles.
STUDY SELECTION
All observational studies and randomized controlled trials published in English that examined the odds ratio (OR) of anemia in patients with HS were screened by 2 independent reviewers. Case reports were excluded. Among 313 unique articles, 7 were deemed eligible.
DATA EXTRACTION AND SYNTHESIS
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines facilitated data extraction. The Newcastle-Ottawa Scale (NOS) was used to analyze risk of bias of included studies. In addition to OR and 95% confidence intervals, relevant data on patient demographics and anemia subtypes were also extracted.
MAIN OUTCOMES AND MEASURES
The primary outcome was the OR of anemia in HS patients. This study also attempted to characterize anemia subtypes associated with HS.
RESULTS
In total, 2 case-control and 5 cross-sectional studies featured a total of 11,693 patients. Among the studies, 4 of 7 demonstrated a statistically significant positive association between anemia and HS (ORs, 2.20 [1.42 to 3.41], 2.33 [1.99 to 2.73], 1.87 [1.02 to 3.44], and 1.50 [1.43 to 1.57]), with macrocytic and microcytic subtypes being most common. After adjusting for publication bias, meta-analysis with random effects revealed HS to be associated with increased odds of anemia compared to non-HS groups (OR 1.59 [1.19, 2.11])
CONCLUSIONS AND RELEVANCE
There is a statistically significant positive association between HS and anemia, particularly for the aforementioned subtypes. Patients with HS should be screened for anemia. In case of lower hemoglobin concentration, the anemia of HS patients should be subdivided according to mean corpuscular volume of the red blood cells and further investigated depending on subtype.
Implementation of a telerehabilitation program for oncosurgical patients during the COVID-19 pandemic: perspectives and user satisfaction
Authors: Parraguez Luz Alejandra Lorca , Ribeiro Ivana Leao , Hinojosa Marta Pizarro , Troncoso Jorge Plasser 
Published: November 2022

Abstract
Introduction

Many rehabilitation services in the face of the COVID-19 health emergency have had to adapt face-to-face interventions with remote care through telerehabilitation. We aim to describe the implementation of a telerehabilitation program during the COVID-19 pandemic for patients who are candidates for elective cancer surgery in a low-income Chilean public hospital. Secondarily, describe the perspectives and satisfaction of users with the program.

Material and methods

Correspond to a descriptive and retrospective study. Implementation was measured in terms of, recruitment rate, retention, dropouts, and occurrence of adverse events. User perspectives and satisfaction were evaluated through a survey composed of nine items on a Likert scale with five response options. Descriptive analyses were considered with mean, standard deviation, minimum, maximum, as well as absolute and relative frequency. For patients' perspectives on the program, a qualitative analysis was considered to describe them. The most relevant domains were identified in a text box to illustrate the results.

Results

155 patients were referred to the telerehabilitation program, with 99.3% recruitment, a retention rate of 46.7% and no adverse events reported. In relation to user satisfaction, in general, patients showed good satisfaction with the telerehabilitation program except items 1 and 8 of the survey. Thirty-three patients reported their perspectives on the intervention, represented in 12 domains.

Conclusion

It is possible to implement a telerehabilitation program for oncosurgical patients in the context of preoperative care during the COVID-19 pandemic, with good user satisfaction. Likewise, this study provides guidance for other health institutions that wish to implement a telerehabilitation program.
Forecasting seasonality and trend of tuberculosis prevalence in India using SARIMA-NNAR Hybrid model
Authors: Baikunth Baikunth Kumar Yadav , Su Sunil Kumar Srivastava , Pranveer Pranveer Singh 
Published: November 2022

Abstract

Early detection of tuberculosis (TB) is very important for control and prevention. We aim to study the current status of tuberculosis prevalence in India by applying an appropriate model that can forecast TB incidence by analyzing the seasonality and trends using past time series data. Notified TB incidence data was extracted from open resources, i.e., Central Tuberculosis Division (CTB), Government of India from 2017 to 2019. A SARIMA model and a hybrid model combining SARIMA with Neural Network Autoregressive (SARIMA-NNAR) models were applied to fit the data and forecast the notified TB incidence. Counterfeiting performance parameters, MSE, RMSE, MAE, MPE, MASE, and MAPE were used to analyze the goodness fit of the models. Reported notified TB incidence data of 2020 were used to validate the models. Both models could reasonably predict and forecast the notified TB incidence, but a hybrid model demonstrated better results when compared to the individual models. In the hybrid model, the RMSE, MAE, and MAPE were (5260.359), (3910.648), and (2.080665) respectively whereas in the SARIMA model the corresponding values were (6712.889), (4863.659), and (2.644319) respectively. Therefore, the hybrid model was more effective in predicting the seasonality and trend of TB incidence than the individual SARIMA model. The hybrid model showed better TB incidence forecasting than the SARIMA. This model will help the government to develop better control strategies for the overall management, control, and eradication of the disease.
Going viral: a science communication collaboration in the era of COVID-19 and social media
Authors: Wiles Siouxsie , Morris Toby , Priestley Rebecca 
Published: November 2022

Abstract
On 9 March 2020, two days before the World Health Organization declared COVID-19 a global pandemic, microbiologist and infectious diseases expert Associate Professor Siouxsie Wiles released the first output from her collaboration with cartoonist Toby Morris: an animated GIF (Graphics Interchange Format) known as ‘Flatten the Curve’. The graphic went viral on Twitter with over 10 million impressions in three days. Flatten the Curve was the first of more than 70 graphics produced by the Wiles and Morris collaboration, all designed as accessible visual communication about COVID-19. The graphics, all released under a Creative Commons CC-BY-SA-4.0 license, have been translated into multiple languages, used by communities, politicians, and public health officials around the world, and the collaborators have won multiple awards for their work.
Gear manufacture process by using chilled ductile iron casting
Authors: Guterres Natalino Fonseca D. S. 
Published: November 2022

Abstract
Ductile Iron has been used many times for the manufacture of components by casting, one of them is gears. The gear manufacturing method is one of the determinations of gear performance in service life. Wear and contact fatigue are important cases to consider during gear operation and the cause is surface hardness and dimensional accuracy. The purpose of this study was to investigate the surface behavior and gear profile dimension accurately. Gear chilled casting using an open mold made of silica sand. The chill will be coated to the surface of the mold wall then pouring at a temperature of 1400oC. Chill creates a good cooling rate on the surface to form FeC3 and M7C3 and (FeCrC)7C3, then produce a hardness of 700-994.96HV. Using chill thickness is 0.4mm, the dimensional accuracy of tooth thickness, pitch circular, and addendum circle diameter is very precise after the finishing process.
Impact of Vitamin D Supplementation on Menstrual Cycle Irregularities
among Women with Polycystic Ovary Syndrome who were Treated with
Metformin: A Systematic Review with Meta-Analysis
Authors: Alenzi Ebtihag O. 
Published: November 2022

Background:
There is inconsistency in the evidence about the effect of adding vitamin D
supplements to metformin therapy among women with polycystic ovary syndrome (PCOS).

Objective:
In this systematic review, we described the differences in menstrual cycle irregularities between
women who received vitamin D supplementation and those who didn’t receive vitamin D
among women who diagnosed with PCOS and received metformin.

Methods:
We reviewed previous literature to identify all relevant studies. The included studies' quality
and risk of bias were assessed using the Consolidated Standards of Reporting Trials (CONSORT) and
the Reporting of Observational Studies in Epidemiology (STROBE) instrument. Cochrane's Q-test and
I2 statistic were used to assess the heterogeneity across included studies. The fixed-effect model was
used to calculate the total effect size.

Results:
Six studies were included, involving 633 women diagnosed with PCOS. Supplementation of
vitamin D with metformin could have a significant impact on the improvement of menstrual cycles
compared to receiving metformin alone (OR = 2.11, 95% CI, 1.40- 3.19). There was no evidence of
heterogeneity across included studies. Subgroup analysis showed that the magnitude of the association
increased when only infertile women with PCOS were included (OR = 2.37, 95% CI, 1.52-3.72).

Conclusion:
This evidence suggests the possible benefit of adding vitamin D to metformin in regulating
the menstrual cycle among women with PCOS, especially infertile women.
MATLAB Simulation and Analysis of Effect of Stiffness to Damping Ratio and Variable Road Elevations on Vehicular Driving Comfort and Safety
Authors: Iskandarani Mahmoud Zaki 
Published: November 2022

Background and Objective:
In this work, it is proposed that the use of variation in Tire Spring Length (Ls (Tire)), Suspension Spring Length (Ls (Suspension)) together with changes in Sprung Mass Acceleration (SMA), all as a function of Suspension Stiffness to Damping Ratio (k:c) and Road Elevation (E), will provide the required indicators to enable vehicle drive strategy and optimize autonomous vehicle automatic selection.

Methods:
MATLAB simulation is performed using three main k:c ratios (1, 20, 0.27) and three main road elevations (1, 3, 5) to achieve the stated objective of this work.

Results:
It is shown through this work that there is a relationship between spring length variation for both tire and suspension, road elevation, and sprung mass acceleration, such that driving strategy can be optimized according to road profile and k:c ratio using these parameters and the intersection of points between tire spring length variation and suspension spring length variation as a function of time and road elevation. Criteria are established in this research for the design and operation of driving strategy, such that three points of selection are used to enable either comfort or handling mode driving strategy.

Conclusion:
The final findings confirmed that for better handling, the Spring Length Variation Ratio (SLVR) should be less than one, with a steady increase in SMA and a minimum number of intersections between the tire spring length variation curve and suspension spring variation length curve as a function of road elevation and time. The presented work suggested through Tables 6 and 7 criteria to enable design for mode switching of autonomous vehicles as a function of road conditions.
Interventions Undertaken by the Parents in Managing their Youth Abusing Substances in Selected Hospitals, Limpopo Province, South Africa
Authors: Hlahla L.S. , Mothiba T. M. 
Published: November 2022

Background:Parents have a significant influence on managing and reducing the risk of substance abuse in the youth. Parents’ support and responsiveness to substance abuse progressively produce positive outcomes. They are driven by their parental instincts to help and protect their youth. Thus, when their youth abuse substances, they would do all they can to prevent the use of substances by their youth. They may use different methods to manage their youth before considering going to the hospital for help. This study investigated the interventions the parents use in managing their youth at home to make sure that they do not use the substances.Methods:A qualitative approach with the phenomenological design was adopted to explore parents’ intervention for youth abusing substances. Parents were purposively selected to participate in the study parents. Data collected through semi-structured interviews were analyzed using Tesch’s steps for qualitative data analysis.Results:Parents implemented various interventions to reduce and manage substance abuse in their youth. Some of the interventions included consultations with agents to assist their youth and raise awareness regarding substance abuse's dangers to their youth.Conclusion:The study findings have indicated that parents use various methods to ensure that their youth do not use substances. There is a need for regular meetings between parents and health care providers. It is recommended that parents consult with the health care providers on managing their youth abusing substances.
relevance of green branding on competitive strategies in service firms
Authors: Morka Ogor Tessy , Aliku Ifeanyi Harold 
Published: November 2022

The study evaluated qualitatively the relevance of green branding in service firms. Drawing the manufacturing industry perspective. Two objectives were drawn for this bordering on environmental actors and green innovation as it affects competitive advantage, The extant literature revealed a strong impact of these predator variables on competitive advantage in service industry management. The findings was that the performance of green innovation, product and process has a positive influence on the performance of the firms, although green innovation process is rarely discussed in the literature, it is very important to highlight the green innovation process, as it is easy to imitate the final product, compared to the process. Recommendations were made on the need to continue to uphold green innovation and major environmental factors to promote firm performance and profitability.
Development and Validation of a Lifetime Risk Model for Kidney Failure and Treatment Benefit in Type 2 Diabetes
Authors: Østergaard Helena Bleken , Read Stephanie H. , Sattar Naveed , Franzén Stefan , Halbesma Nynke , Dorresteijn Jannick A.N. , Westerink Jan , Visseren Frank L.J. , Wild Sarah H. , Eliasson Björn , van der Leeuw Joep 
Published: November 2022

Background and objectives
Individuals with type 2 diabetes are at a higher risk of developing kidney failure. The objective of this study was to develop and validate a decision support tool for estimating 10-year and lifetime risks of kidney failure in individuals with type 2 diabetes as well as estimating individual treatment effects of preventive medication.

Design, setting, participants, & measurements
The prediction algorithm was developed in 707,077 individuals with prevalent and incident type 2 diabetes from the Swedish National Diabetes Register for 2002–2019. Two Cox proportional regression functions for kidney failure (first occurrence of kidney transplantation, long-term dialysis, or persistent eGFR <15 ml/min per 1.73 m2) and all-cause mortality as respective end points were developed using routinely available predictors. These functions were combined into life tables to calculate the predicted survival without kidney failure while using all-cause mortality as the competing outcome. The model was externally validated in 256,265 individuals with incident type 2 diabetes from the Scottish Care Information Diabetes database between 2004 and 2019.

Results
During a median follow-up of 6.8 years (interquartile range, 3.2–10.6), 8004 (1%) individuals with type 2 diabetes in the Swedish National Diabetes Register cohort developed kidney failure, and 202,078 (29%) died. The model performed well, with c statistics for kidney failure of 0.89 (95% confidence interval, 0.88 to 0.90) for internal validation and 0.74 (95% confidence interval, 0.73 to 0.76) for external validation. Calibration plots showed good agreement in observed versus predicted 10-year risk of kidney failure for both internal and external validation.

Conclusions
This study derived and externally validated a prediction tool for estimating 10-year and lifetime risks of kidney failure as well as life years free of kidney failure gained with preventive treatment in individuals with type 2 diabetes using easily available clinical predictors.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2022_11_04_CJN05020422.mp3.
Safety and effectiveness of intranasal esketamine for treatment-resistant depression: a real-world retrospective study
Authors: Brendle Madeline , Ahuja Sachin , Valle Maisa Della , Moore Claire , Thielking Paul , Malone Daniel C , Robison Reid 
Published: November 2022

Aim:
There is limited real-world evidence for patients with treatment-resistant depression (TRD) receiving esketamine nasal spray.
Methods:
This retrospective cohort study used data collected from a psychiatric clinic's EHR system.
Results:
A total of 171 TRD patients received esketamine July 2019–June 2021. This predominantly female, white population had several mental health comorbidities and high exposure to psychiatric medications. We observed significant reductions (p < 0.001) in average PHQ-9 and GAD-7 scores from baseline (PHQ-9: mean: 16.7; SD: 5.8; GAD-7: mean: 12.0; SD: 5.8) to last available treatment (PHQ-9: mean: 12.0; SD: 6.4; GAD-7: mean: 8.7; SD: 5.6). There were no reports of serious adverse events.
Conclusion:
This study found a significant disease burden for patients with TRD. Esketamine appears to be well tolerated and effective in improving depression and anxiety.
Aplicación foliar de extracto de algas y fertilizantes en pimiento (Capsicum annuum)
Authors: Salazar-Salazar Werner , Monge-Pérez José Eladio , Loría-Coto Michelle 
Published: November 2022

Introducción: Los extractos de algas marinas tienen actividad bioestimulante que mejoran el crecimiento y rendimiento en muchos cultivos, y pueden mejorar la absorción de minerales. Objetivo: Evaluar el efecto de la aplicación foliar de extracto de algas y fertilizantes (tratamientos: extracto de algas (A); fertilizantes (FF); extracto de algas+fertilizantes (A+FF); y testigo-T) sobre el rendimiento y calidad del pimiento cultivado bajo invernadero. Métodos: El cultivo se manejó en sustrato de fibra de coco y con fertirrigación. Las variables evaluadas fueron: número de frutos por planta, peso del fruto (g), rendimiento (ton/ha), porcentaje de sólidos solubles totales (°Brix), contenido de clorofila (atLEAF), área foliar (cm2), peso seco foliar (g), peso específico foliar (mg/cm2), altura de planta (cm), y diámetro de tallo (mm). Los tratamientos se aplicaron a partir de los 14 días después del trasplante (ddt), y se realizaron en forma semanal hasta el final del ensayo (154 ddt). Resultados: Los tratamientos A y A+FF produjeron una cantidad superior de frutos comerciales y totales por planta, y un rendimiento comercial y total superior, en comparación con FF y T. El tratamiento A+FF produjo frutos con mayor peso, en comparación con T, tanto a nivel comercial como total. No se hallaron diferencias significativas entre tratamientos para las siguientes variables: área foliar, peso seco foliar, peso específico foliar, altura de planta y diámetro de tallo. Conclusión: El uso del extracto de algas (A) produjo el mayor rendimiento total y comercial al menor costo, por lo que se recomienda su uso; además, la aplicación de fertilizantes foliares (FF) no mejoró ni el rendimiento ni la calidad en el cultivo de pimiento, bajo las condiciones del ensayo.