bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stanisław Kamiński’s Philosophy as Christian Philosophy
Authors: Mbamara Sebastine Kingsley 
Published: January 2022

This article argues that Kaminski’s concept of philosophy meets the requirements for being a Christian philosophy as articulated by John Paul II. In the encyclical letter Fides et Ratio, John Paul II affirmed the possibility, existence, meaning, and need for a Christian philosophy. He distinguished three stances of philosophy concerning the Christian faith. First, philosophy should be completely independent of the Biblical Revelation but implicitly open to the supernatural. A second stance adopted by philosophy is often designated as Christian philosophy. Third, philosophy presents another stance that is closely related to theology. Kamiński constructed an understanding of philosophy that is original, universal, and autonomous. Such a notion of philosophy (and its methodology) was based on the classical theory of being, which fulfils the demand for the autonomy of philosophy through its relationship with faith. Kamiński’s doctrinal standpoints in philosophy are rational, objective, and universal. According to him, philosophy is also compatible with the Christian faith. In this sense, one can speak of his philosophy as a Christian philosophy.
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Received: 22/04/2021. Reviewed: 06/09/2021. Accepted: 23/10/2021.
Michał Jakub Wagner, „Interpretacje rozwoju biologii ewolucyjnej na przełomie XIX i XX wieku”, Liber Libri, Warszawa 2020, ss. 332 (rec.)
Authors: Świeżyński Adam 
Published: January 2022

Autor omawianej publikacji podjął się zadania przeanalizowania zaproponowanych dotąd interpretacji „zaćmienia darwinizmu”, chcąc ustalić, w jakim stopniu odpowiadają one rzeczywistości. Po dokonaniu ustaleń w tym zakresie doszedł do wniosku, że żadna z nich nie wyjaśnia w sposób adekwatny załamania się, jakie dotknęło teorię Darwina we wspomnianym okresie. Dlatego postanowił zaproponować własną interpretację „zaćmienia darwinizmu”, w której odwołuje się przede wszystkim do filozoficznych uwarunkowań darwinowskiej teorii ewolucji.
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Zgłoszono: 04/08/2021. Zrecenzowano: 19/08/2021. Zaakceptowano do publikacji: 06/09/2021.
Current Trends and Applications of Food-derived Antihypertensive
Peptides for the Management of Cardiovascular Disease
Authors: Shukla Pratik , Chopada Keval , Sakure Amar , Hati Subrota 
Published: January 2022

Abstract:
Food derived Antihypertensive peptides is considered as a natural supplement for controlling the hypertension. Food protein not only serve as a macronutrient but also act as raw material for biosynthesis of physiologically active peptides. Food sources like milk and milk products, animal protein such as meat, chicken, fish, eggs and plant derived proteins from soy, rice, wheat, mushroom, pumpkins contain high amount of antihypertensive peptides. The food derived antihypertensive peptides has ability to supress the action of rennin and Angiotesin converting enzyme (ACE) which is mainly involved in regulation of blood pressure by RAS. The biosynthesis of endothelial nitric oxide synthase is also improved by ACE inhibitory peptides which increase the production of nitric oxide in vascular walls and encourage vasodilation. Interaction between the angiotensin II and its receptor is also inhibited by the peptides which help to reduce hypertension. This review will explore the novel sources and applications of food derived peptides for the management of hypertension.
Bioinformatics and Computer Simulation Approaches to the Discovery and
Analysis of Bioactive Peptides
Authors: Li Gao , Shuli Zhang , Linlin Liu , Yinghu Zhao , Nan Shi , Haibin Wang , Hongyu Xu 
Published: January 2022

Abstract:
The traditional process of separating and purifying bioactive peptides is laborious and time-consuming. Using a traditional process to identify is difficult, and there is a lack of fast and accurate activity evaluation methods. How to extract bioactive peptides quickly and efficiently is still the focus of bioactive peptides research. In order to improve the present situation of the research, bioinformatics techniques and peptidome methods are widely used in this field. At the same time, bioactive peptides have their own specific pharmacokinetic characteristics, so computer simulation methods have incomparable advantages in studying the pharmacokinetics and pharmacokinetic-pharmacodynamic correlation models of bioactive peptides. The purpose of this review is to summarize the combined applications of bioinformatics and computer simulation methods in the study of bioactive peptides, concentrating on the role of bioinformatics in simulating the selection of enzymatic hydrolysis and precursor proteins, activity prediction, molecular docking, physicochemical properties, and molecular dynamics. Our review shows that new bioactive peptide molecular sequences with high activity can be obtained by computer-aided design. The significance of the pharmacokinetic-pharmacodynamic correlation model in the study of bioactive peptides is emphasized. Finally, some problems and future development potential of bioactive peptides binding new technologies are being prospected.
Multilocular Thymic Cyst in a Patient with Untreated HIV/AIDS: Case Report
and Review of the Literature
Authors: Czech Mary M. , Ogden William , Batra Rashmi , Cooper Joseph D. 
Published: January 2022

Background:
Multilocular thymic cysts (MTCs) in adults with human immunodeficiency
virus (HIV) are rarely reported.

Case Presentation:
We describe a case of symptomatic MTC in a male with untreated HIV. A presumptive
diagnosis was established based on radiographic imaging and biopsy. Pathologic diagnosis
and exclusion of malignancy were ultimately confirmed following thymectomy. In conjunction
with starting antiretroviral therapy, the patient recovered well post-operatively with a resolution of
his presenting symptoms.

Conclusion:
Our case report and review of the literature serve to highlight MTCs as an important
clinical entity occurring in persons with HIV.
Patient-Physician Communication in Acute Myeloid Leukemia and Myelodysplastic Syndrome
Authors: Morelli Emanuela , Mulas Olga , Caocci Giovanni 
Published: January 2022

Introduction:
An effective communication is an integral part of the patient-physician relationship. Lack of a healthy patient-physician relationship leads to a lower level of patient satisfaction, scarce understanding of interventions and poor adherence to treatment regimes. Patients need to be involved in the therapeutic process and the assessment of risks and perspectives of the illness in order to better evaluate their options. Physicians, in turn, must convey and communicate information clearly in order to avoid misunderstandings and consequently poor medical care. The patient-physician relationship in cancer care is extremely delicate due to the complexity of the disease. In cancer diagnosis, the physician must adopt a communicative approach that considers the psychosocial factors, needs and patient’s preferences for information,which in turn all contribute to affect clinical outcomes.

Search Strategy and Methods
:

This review was conducted using the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement. We included studies on the importance of physician-patient communication in Acute Myeloid Leukaemia and Myelodysplastic Syndrome care. We searched PubMed, Web of Sciences, Scopus, Google scholar for studies published from December 1

st

, 2020 up to March 1

st

, 2021. Using MeSH headings, we search for the terms “Physician and patient communication AND Acute Myeloid leukemia” or “Myelodysplastic syndrome” or “Doctor” or “Clinician”, as well as variations thereof .

Purpose of the Review
:

This review examines the progress in communication research between patient and physician and focuses on the impact of communication styles on patient-physician relationshipin hematologic cancers, including Acute Myeloid Leukaemia and Myelodysplastic Syndromes.
The Difficult Task of Diagnosing Depression in Elderly People with Cancer: A Systematic Review
Authors: Massa Elena , Donisi Clelia , Liscia Nicole , Madeddu Clelia , Impera Valentino , Mariani Stefano , Scartozzi Mario , Lai Eleonora 
Published: January 2022

Background:
Depression is a common psychiatric problem in the elderly and oncology patients. In elderly people with cancer, depression has a peculiar phenomenology. It has a significant impact on the quality of life. Moreover, it is associated with poor adherence to treatments, increased risk of suicide, and mortality. Nevertheless, the topic of depression in elderly people with cancer remains unexplored.

Objective:
The main goal of this article is to review the literature from the past 20 years on the relationships between depression, cancer, and aging.

Methods:
The methods followed the Prisma model for eligibility of studies. The articles in which the keywords “depression”, “cancer”, “ elderly, aging, or geriatric” were present, either in the text or in the abstract, were selected. 8.056 articles, by matching the keywords “depression and elderly and cancer,” were identified. Only 532 papers met the eligibility criteria of search limits and selection process. Out of 532 papers, 467 were considered irrelevant, leaving 65 relevant studies. Out of 65 suitable studies, 39 (60.0%) met our quality criteria and were included.

Results:
The risk factors associated with depression in elderly people with cancer can be divided into 4 groups: 1) tumor-related; 2) anticancer treatment-related; 3) patients-related; 4) number and type of comorbidity. The main obstacles in diagnosing depression in elderly patients with cancer are the overlap of the symptoms of cancer and side effects of treatment with the symptoms of depression but also the different ways of reporting depressive symptoms of elderly people and the different clinical types of depression. There is a lack of data regarding validated scales to assess depression in geriatric patients with cancer. Any mental illness, specifically co-occurring anxiety and depression, increases the risk of diagnosis delay and anticancer treatment adherence. Cancer and the diagnosis of mental disorders prior to cancer diagnosis correlate with an increased risk for suicide. A non-pharmacological therapeutic approach, pharmacological treatment and/or a combination of both can be used to treat elderly patients with cancer, but a detailed analysis of comorbidities and the assessment of polypharmacy is mandatory in order to avoid potential side-effects and interactions between antidepressants and the other drugs taken by the patients.

Conclusion:
Future research should be conducted with the aim of developing a modified and adapted assessment method for the diagnosis and treatment of depression in elderly people with cancer in order to improve their clinical outcomes and quality of life.
The Quality of Life of People with Solid Cancer is Less Worse than Other Diseases with better Prognosis, Except in the Presence of Depression
Authors: Aviles Gonzalez Cesar Ivan , Angermeyer Matthias , Deiana Laura , Loi Caterina , Murgia Elisabetta , Holzinger Anita , Cossu Giulia , Massa Elena , Romano Ferdinando , Scartozzi Mario , Carta Mauro Giovanni 
Published: January 2022

Background:
Suffering from Solid Cancer (SC) may adversely impact the Health-related Quality of Life (H-QoL). The aims of this study are to measure the H-QoL in a sample of people suffering from SC and to clarify the role of the co-occurrence of depressive episodes. Results were compared with a healthy control group and with groups of other disorders.

Methods:
In 151 patients with SC (mean±sd age 63.1±11.5; female 54.3%), H-QoL was assessed by SF-12, depressive episodes were identified by PHQ-9. The attributable burden of SC in impairing H-QoL was calculated as the difference between SF-12 score of a community sex and age ¼ matched healthy control group and that of the study sample. The attributable burden of SC was compared with other chronic diseases using specific diagnostic groups drawn from case-control studies that used the same database for selecting control samples.

Results:
H-QoL in people with SC was significantly worse than in the healthy control group (p<0.0001). The attributable burden in worsening the H-QoL due to SC was similar to those of severe chronic diseases, but lower than Multiple Sclerosis (p<0.0001) or Fibromyalgia (p<0.00001). Having a depressive episode was a strong determinant of decreasing H-QoL, regardless of the severity of cancer.

Conclusion:
The findings confirm a strong impact of SC but showed that H-QoL in SC was higher than in chronic diseases with better “quoad vitam” outcome. Since depression was a strong determinant, its prevention, early detection and therapy are the main objectives that must be reached in cancer patients.
The Reliability and Test-Retest Stability of the Treatment Perception Questionnaire (TPQ) in the Oncology Field: A Pilot Study
Authors: Sancassiani Federica , Gambino Sara , Lindert Jutta , Sali Lapo , Pinna Irene , Origa Giulia , Cossu Giulia , Scartozzi Mario , Preti Antonio 
Published: January 2022

Background:
Patients' satisfaction is an indicator of technical, instrumental, environmental, and interpersonal aspects of care. It shows how much the health service “as a whole organization” meets the patients’ psychosocial expectations and if the health professionals combine their technical competence with relational skills. The Treatment Perception Questionnaire (TPQ) is a brief instrument developed in the United Kingdom for research with substance abuse disorder populations. The present study aimed at evaluating the reliability and test-retest stability of the TPQ Italian translation in a sample of patients with solid and blood cancers.

Methods:
The TPQ was administered to 263 people with solid and blood cancers. Test-retest reliability was evaluated in a subgroup of 116 participants who completed the TPQ again after 3 months.

Results:
The reliability of TPQ was good. Cronbach’s alpha: 0.83 (95%CI: 0.79-0.86), 0.66 (0.59-0.72), 0.71 (0.65-0.769), respectively, in the total test, and in subscales on “staff perception”, and “program perception”. Test-retest reliability was 0.82 (0.77-0.87). The mean difference between the first and the second assessment was 1.0 (SD = 7.1; 95% CI -0.35 to 2.33). By plotting the differences and the means of the two assessments, 5/116 cases (4.3%) were outside the upper and lower limits of agreement.

Conclusions:
This study points out good reliability and test-retest stability of the TPQ in the oncology field. The TPQ can be used to assess variation over time about satisfaction with care in patients with oncological diseases, favoring the identification of unmet patients’ needs about the quality of the service.
Evaluation of Oxidation Process by Ozonation and Glucose Oxidase Enzyme on the Degradation of Benzoquinone in Wheat Flour
Authors: El-Desouky Tarek A. , Hussain Hassan B.H. 
Published: January 2022

Background:
Wheat flour is an important food ingredient for humans, which is the basic ingredient of bread and other bakery products.

Objective:
This study aimed to assess the effect of adding Glucose Oxidase (GOX), and exposure to ozone gas on methyl-1, 4-benzoquinone (MBQ), and ethyl-1, 4-benzoquinone (EBQ) secreted by Tribolium castaneum in flour.

Methods:
The flour contaminated by MBQ and EBQ was treated with ozone gas at (10, 20, and 40 ppm) with exposure times (15, 30, and 45 min). Similarly, GOX was added to flour at (10, 15, and 20 ppm), leaving the dough for periods between 10 and 45 min after treatments. The MBQ and EBQ determined by HPLC, and the UV-Visible Spectrophotometer and Fourier Transform Infrared Spectroscopy (FTIR) were used to describe the changes that occurred in the main structure of EBQ after ozonation at 40 ppm for 45 min.

Results:
The results indicated that adding GOX enzyme to the flour at level 20 ppm degrade the MBQ to 13.7, 20.23, and 39.6 after 15, 30, and 45 min from mixing time, respectively. On the other hnad, the EBQ degrades to 13.6, 18.9, and 35.9%. In contrast, the percentages of degradation of MBQ and EBQ increases after ozonation at 40 ppm for 45min were 84.1 and 78.8%, respectively. The results obtained by UV–vis spectroscopy and FTIR reflect that many oxidation products formed as aldehydes, ketones, and carboxylic acids.

Conclusion:
In general, ozonation was a reliable treatment for the degradation of benzoquinone in flour.
A Novel Approach to Information Security in Medical Sensor Networks
Authors: Karunakaran Kalaivani , Rajagopal Sivakumar 
Published: January 2022

Objective:Preservation of patient’s medical information in health care industries under Medical Sensor Networks (MSN).Methods:This paper proposes a novel key management technique known as k- secure with FBKM, which generates a robust key to allow communication between sensors present in the Body Sensor Units (BSU) and Body Central Unit (BCU). This proposed work strengthens the FBKM technique which is placed between BCU and the point accessible to medical experts at a remote place in the overall health care monitoring environment.Results:The FBKM technique has proved its success in authentication and security by improving genuine acceptance rate, false rejection rate, and declining false acceptance rate.Conclusion:The k- secure with FBKM scheme enhances the performance of the existing FBKM scheme in Medical Sensor Networks.
Neural Network Based Filtering Method for Cancer Detection
Authors: Jaya J. , Sasi A. , Paulchamy B. , Sabareesaan K.J. , Rajagopal Sivakumar , Balakrishnan Nagaraj 
Published: January 2022

Objective:
The growth of anomalous cells in the human body in an uncontrolled manner is characterized as cancer. The detection of cancer is a multi-stage process in the clinical examination.

Methods:
It is mainly involved with the assistance of radiological imaging. The imaging technique is used to identify the spread of cancer in the human body. This imaging-based detection can be improved by incorporating the Image Processing methodologies. In image processing, the preprocessing is applied at the lower-level abstraction. It removes the unwanted noise pixel present in the image, which also distributes the pixel values based on the specific distribution method.

Results:
Neural Network is a learning and processing engine, which is mainly used to create cognitive intelligence in various domains. In this work, the Neural Network (NN) based filtering approach is developed to improve the preprocessing operation in the cancer detection process.

Conclusion:
The performance of the proposed filtering method is compared with the existing linear and non-linear filters in terms of Mean Squared Error (MSE), Peak Signal to Noise Ratio (PSNR) and Image Enhancement Factor (IEF).
Novel Multi-Modal Throat Inflammation and Chest Radiography based Early-Diagnosis and Mass-Screening of COVID-19
Authors: Ramwala Ojas A. , Dalal Poojan , Parikh Parima , Dalal Upena , Paunwala Mita C. , Paunwala Chirag. N. 
Published: January 2022

Background:
The upsurge of COVID-19 has received significant international contemplation considering its life-threatening ramifications. To ensure that the susceptible patients can be quarantined to control the spread of the disease during the incubation period of the coronavirus, it becomes imperative to automatically and non-invasively mass screen patients. The diagnosis using RT-PCR is arduous and time-consuming. Currently, the non-invasive mass screening of susceptible cases is being performed by utilizing the thermal screening technique. However, with the consumption of paracetamol, the symptoms of fever can be suppressed.

Methods:
A novel multi-modal approach has been proposed. Throat inflammation-based mass screening and early prediction followed by Chest X-Ray based diagnosis have been proposed. Depth-wise separable convolutions have been utilized by fine-tuning Xception Net and Mobile Net architectures. NADAM optimizer has been leveraged to promote faster convergence.

Results:
The proposed method achieved 91% accuracy on the throat inflammation identification task and 96% accuracy on chest radiography conducted on the dataset.

Conclusion:
Evaluation of the proposed method indicates promising results and henceforth validates its clinical reliability. The future direction could be working on a larger dataset in close collaboration with the medical fraternity.
High Flow Nasal Cannula as Support in Immunocompromised Patients with Acute Respiratory Failure: A Retrospective Study
Authors: Giugliano-Jaramillo Claudia , León Josefina , Enriquez Cristobal , Keymer Juan E. , Pérez-Araos Rodrigo 
Published: January 2022

Introduction:
High Flow Nasal Cannula (HFNC) is a novel technique for respiratory support that improves oxygenation. In some patients, it may reduce the work of breathing. In immunocompromised patients with Acute Respiratory Failure (ARF), Non-Invasive Ventilation (NIV) is the main support recommended strategy, since invasive mechanical ventilation could increase mortality rates. NIV used for more than 48 hours may be associated with increased in-hospital mortality and hospital length of stay. Therefore HFNC seems like a respiratory support alternative.

Objective:
To describe clinical outcomes of immunocompromised patients with ARF HFNC-supported.

Methods:
Retrospective study in patients admitted with ARF and HFNC-supported. 25 adult patients were included, 21 pharmacologically and 4 non- pharmacologically immunosuppressed. Median age of the patients was 64 [60-76] years, APACHE II 15 [11-19], and PaO2:FiO2 218 [165-248]. Demographic information, origin of immunosuppression, Respiratory Rate (RR), Heart Rate (HR), Mean Arterial Pressure (MAP), oxygen saturation (SpO2) and PaO2:FiO2 ratio were extracted from clinical records of our HFNC local protocol. Data acquisition was performed before and after the first 24 hours of connection. In addition, the need for greater ventilatory support after HFNC, orotracheal intubation, in-hospital mortality and 90 days out-patients’ mortality was recorded.

Results:
Mean RR before the connection was 25±22 breaths/min and 22±4 breaths/min after the first 24 hours of HFNC use (95% CI; p=0.02). HR mean before connection to HFNC was 96±22 beats/min, and after, it was 86±15 beats/min (95%CI; p=0.008). Previous mean MAP was 86±15 mmHg, and after HFNC, it was 80±12 mmHg (95%CI; p=0.09); mean SpO2 after was 93±5% and before it was 95±4% (95% CI; p=0.13); and previous PaO2:FiO2 mean was 219±66, and after it was 324±110 (95%CI; p=0.52). In-hospital mortality was 28% and 90 days out-patients’ mortality was 32%.

Conclusion:
HFNC in immunosuppressed ARF subjects significantly decreases HR and RR, being apparently an effective alternative to decrease work of breathing. In-hospital mortality in ARF immunosuppressed patients was high even though respiratory support was used. Better studies are needed to define the role of HFNC-support in ARF.