bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic factors for treatment response and survival outcomes after first-line management of Stage 4 non-small cell lung cancer: A real-world Indian perspective
Authors: Garg Avneet , Iyer Hariharan , Jindal Vinita , Vashistha Vishal , Ali Ashraf , Jain Deepali , Tiwari Pawan , Mittal Saurabh , Madan Karan , Hadda Vijay , Guleria Randeep , Sati Hem Chandra , Mohan Anant 
Published: February 2022

Background:
Indian data on treatment outcomes and survival in advanced non-small cell lung cancer (NSCLC) remain scarce.

Materials and Methods:
A retrospective review of 537 advanced NSCLC patients treated at a tertiary care facility in North India from January 2008 to March 2018 was done to assess treatment response and survival in terms of objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS).

Results:
Median age of enrolled patients was 60 years (range: 26–89 years). The majority were males (78.2%) and smokers (66.5%). Adenocarcinoma (51.2%) was the most common pathological type. Most patients had good performance status (PS) (the Eastern Cooperative Oncology Group [ECOG] 0 or 1 in 55.7%) and received conventional chemotherapy (86.6%). ORR and DCR after 3–4 months of first-line treatment were 55.2% and 71.75%, respectively (n = 223). Never smokers had better ORR as well as DCR compared to chronic smokers whereas treatment with tyrosine kinase inhibitors achieved significantly better ORR, and patients with good PS had better DCR compared to those with poor PS. Median PFS (n = 455) was 7.0 months (95% confidence interval [CI]: 3.7–14.0) and median OS was 11.7 months (95% CI: 5.5–29.9 months). Good PS and nonsmoking status were independent predictors of better PFS on multivariate analysis. For OS, good PS, nonsmoking behavior, and treatment with epidermal growth factor receptor inhibitors were independent predictors.

Conclusion:
In advanced NSCLC, never-smokers, and patients with good baseline ECOG have favorable treatment and survival outcomes. Treatment with targeted therapy results in better ORR and OS but did not affect PFS.
Interventional pulmonology during COVID times: A look back at the year gone by
Authors: Kottaisamy Ramasubramaniam , Aggarwal Manish Kumar , Goyal Rajiv 
Published: February 2022

Background:
The COVID-19 pandemic has created an unprecedented crisis, affecting every sphere of human life. A major challenge for health care workers (HCWs) is to care for patients with a highly contagious airborne disease, while making sure of their own safety. Interventional pulmonology (IP) procedures, like bronchoscopy, are particularly risky due to significant aerosol generation. Guidelines by several scientific bodies were framed on the precautions to be taken while performing IP procedures. We evaluated the IP procedures performed during the COVID-19 pandemic, and whether the precautions adopted proved adequate in preventing transmission amongst the HCWs involved in these procedures.

Method:
We performed a retrospective analysis of all patients who underwent IP procedures between March 2020 and November 2020, at a tertiary cancer hospital. We also evaluated the proportion of HCWs, who were involved in these procedures, and were affected by COVID-19, through their health care records.

Results:
We performed a total of 506 IP procedures. Two of the 18 HCWs, working in that unit, suffered from COVID-19 and recovered after a mild illness. Three HCWs were isolated with suspected infection but proved to be negative. The procedures in our IP unit were uninterrupted for the entire duration of the study period.

Conclusion:
IP procedures can be safely performed even in the presence of a highly contagious viral pandemic with adequate precautions.
Comparative study of conventional Ziehl−Neelsen and bleach concentration method in detecting acid-fast bacilli in fine-needle aspiration material of lymph nodes
Authors: Mandal Parnajeet , Ghosh Soma , Banerjee Abhijit , Banerjee Uma 
Published: February 2022

Background:
Tuberculosis (TB), specific infectious disease, affects most of the organs of the human body. Extrapulmonary TB manifests commonly as lymphadenopathy. Emergence of acquired immunodeficiency syndrome warrants the rapid diagnosis to limit its spread.

Aim and Objectives:
The application of bleach concentration method in detecting tubercle bacilli in the material obtained by fine-needle aspiration (FNA) of lymph nodes, evaluating sensitivity of bleach concentration method over conventional direct smear method in diagnosing tubercular lymphadenitis, detecting bacilli in the background of granuloma formation.

Materials and Methods:
The prospective, hospital-based, cross-sectional study was carried out in a study population of 78 patients where 15 cases got eliminated following the cytological diagnosis of malignancy and inadequacy of sample. Patients with lymphadenopathy underwent FNA after clinical examination, history taking, and informed consent. The aspirated material was stained with Leishman, H and E, conventional Ziehl−Neelsen (ZN), and bleach concentration method. Data were collected and statistical analysis done.

Results:
The predominant age group affected was (16–30) years with male preponderance. 44.44% cases were cytomorphologically diagnosed with tuberculous lymphadenitis. Acid-fast Bacilli (AFB) was found in 23 cases by conventional ZN method and 39 cases by bleach concentration method. Sensitivity of bleach method was 92.35% compared to 54.76% in conventional ZN method. Bacilli positivity was more in cases presenting with necrosis than with granuloma alone.

Conclusion:
Bleach method for detecting AFB is more sensitive than conventional ZN method. It is safe, inexpensive, easy to perform, requires no additional equipment, and safe to handle in laboratory.
Case Report: Unremitting COVID-19 Pneumonia, Viral Shedding, and Failure to Develop Anti-SARS-CoV-2 Antibodies for More Than 6 Months in Patient with Mantle Cell Lymphoma Treated with Rituximab
Authors: Berktas Bahadir M. , Koyuncu Adem 
Published: February 2022

ABSTRACT.
Severe cases of COVID-19 are being reported in patients with comorbidities and drug-induced immunosuppression. The risk seems to depend on the type of immunosuppressive agents used, and it is particularly high with rituximab because of its long-lasting effects. We report a 71-year-old man with COVID-19, mantle cell lymphoma, and rituximab-associated immunodeficiency. His COVID-19 clinical course was severe, unremitting, prolonged, and with frequent acute exacerbations requiring hospitalization. Viral shedding and failure to develop anti-severe acute respiratory syndrome coronavirus 2 antibodies continued for at least 6 months.
PENGARUH KOMITMEN ORGANISASI DAN KEPUASAN KERJA TERHADAP KINERJA KARYAWAN (BAGIAN PRODUKSI PT. DHARMA POLIMETAL BALARAJA, TANGERANG)
Authors: Isrial Isrial , M. Ifran , Sugina Sugina 
Published: February 2022

ABSTRACT
Penelitian ini ditujukan untuk menguji pengaruh komitmen organisasi dan kepuasan kerja terhadap kinerja karyawan pada PT. Dharma Polimetal Balaraja, Tangerang. Penelitian ini merupakan penelitian kausal. Populasi penelitian ini adalah karyawan bagian produksi dengan jumlah sampel sebanyak 100 responden. Pemilihan sampel dengan menggunakan teknik probability sampling jenis sampel random sampling. Data dikumpulkan menggunakan metode kuesioner dengan skala ordinal. Alat analisis yang digunakan adalah uji regresi linear berganda yang dijalankan dengan perangkat lunak Statistical Process Social Science (SPSS). Hasil penelitian menujukkan bahwa secara parsial antara komitmen organisasi terhadap kinerja karyawan tidak menunjukan adanya pengaruh yang positif; Sedangkan kepuasan kerja berpengaruh positif terhadap kinerja karyawan, dan adanya pengaruh komitmen organisasi dan kepuasan kerja terhadap kinerja karyawan saecara simultan terdapat pengaruh yang positif.
PENGARUH UANG MUKA DAN LAMA ANGSURAN TERHADAP PENJUALAN MOTOR HONDA PADA DEALER HONDA NYAPAH KECAMATAN WALANTAKA - KOTA SERANG
Authors: Rahmiyanti Sev 
Published: February 2022

ABSTRAK
Kebijakan strategi penjualan dalam penelitian ini mengacu pada uang muka dan lama pemasangan pembayaran dan pengaruhnya terhadap volume penjualan korporasi. Konsumen sensitif dalam hal ini. Oleh karena itu, jumlah uang muka dan lama pemasangan adalah strategi alternatif yang dapat diterapkan perusahaan untuk meningkatkan volume penjualan. Hasil Identifikasi masalah dalam penelitian ini bahwa berkurangnya penjualan motor honda akibat terlalu tinggi uang muka terhadap penjualan motor Honda dan berkurangnya penjualan motor honda akibat lama angsuran yang terlalu singkat terhadap penjualan motor Honda. Selanjutnya rendahnya uang muka dan lama angsuran terhadap penjualan motor Honda, dengan demikian pengaruh uang muka dan lama angsuran mempengaruhi penjualan motor Honda di dealer Honda Nyapah Walantaka – Kota Serang. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penentuan jumlah uang muka dan lama pemasangan terhadap volume penjualan secara simultan pada Dealer Honda Nyapah. Data dianalisis dengan regresi linier berganda.
Hasil Penilitian diketahui bahwa signifikansi uang muka sebesar 0,29 (029 > 0,05) dan untuk t tabel -0,282 < t tabel 2.032 artinya untuk variabel Uang muka berengaruh terhadap penjualan, selanjutnya untuk signifikansi lama angsuran sebesar 0,688 (0.29 < 0,05) dan untuk t tabel -0,406 < t tabel 2.032 artinya untuk variabel lama angsuran berengaruh terhadap penjualan dan hasil Uji F diketahuai nilai signifikasi untuk pengaruh Uang Muka (X1) dam lama angsuran (X2) secara simultan terhadap Y adalah sebesar 0,000 < 0,05 dan nilai F hitung 38,581 > f tabel 3.276 sehingga dapat disimpulan bahwa H3 diterima yang berarti terdapat pengaruh Uang muka dan lama angsuran terhadap penjualan. Berdasarkan hasil analisis di atas, dapat disimpulkan bahwa variabel uang muka dan lama pemasangan berpengaruh signifikan terhadap volume penjualan secara simultan dan variabel uang muka berpengaruh signifikan terhadap volume penjualan secara parsial, sedangkan variabel lama pemasangan tidak signifikan. berpengaruh terhadap volume penjualan sebagian.
Gambaran Infestasi Vektor pada Kapal Penumpang dan Kapal Barang yang Sandar di Pelabuhan Baubau
Authors: Supryatno Adi , Alimin Sischa Andriani 
Published: February 2022

ABSTRACT
High transportation needs can cause health problems, such as vector infestation. Vector infestation is most likely caused by the behavior of the crew, the age of the ship, the number of passengers, the cleanliness of the ship, and resistance to continuous use of pesticides. The purpose of this study was to describe the location of vector infestations on passenger ships and cargo ships that dock at Baubau port. This type of research is a quantitative descriptive using a cross sectional study design. The object of this research is the ships that docked at the Bau-bau port in December 2017 as many as 12 passenger ships and 12 cargo ships. Insect prevalence was measured by calculating the percentage of the number of insects caught. The results of the research were processed descriptively to see a description of the location of vector infestations on passenger ships and cargo ships that docked at Bau-bau Harbor by looking at the characteristics of the ship based on the type of ship and the age of the ship. The results obtained that cockroaches are the vectors with the highest infestation on ships as many as 10 on passenger ships and 11 on cargo ships. The average age of ships that dock at Baubau port is quite old. Vessels > 7 years old have the most vector infestations and cockroaches are one of the most numerous types of vectors.
Keywords: Vector Infestation, Passenger Ship, Freight Ship
Impact of the COVID-19 Pandemic on Burnout Syndrome for Nurses
Authors: Klišys Edgaras , Mikaliūkštienė Aldona , Fatkulina Natalja 
Published: February 2022

Burnout syndrome has been around for decades and affects many professions. Burnout is defined as the exhaustion of physical or emotional strength or motivation, usually as a result of prolonged stress or frustration. Researchers agree that burnout is a process, but divide it into several distinct stages. Burnout syndrome is not only caused by the personal characteristics of individuals working in healthcare settings, but also by a variety of environmental factors that affect each individual in one way or another. In the wake of the COVID-19 pandemic, these factors have been compounded by additional stressors, which have influenced the prevalence of burnout in nurses, and recent studies have shown an increase in the number of nurses suffering from burnout. This has made the prevention and management of burnout even more relevant in today's context.
The aim of this paper is to review and present the recent literature on burnout syndrome experienced by nurses in the COVID-19 setting. Methods - Systematic search of PubMed and Google Scholar databases for articles. The results showed that the COVID-19 pandemic has a significant impact on the occurrence of burnout syndrome in nurses.
PELATIHAN KONSELING MENYUSUI BAGI KELOMPOK TENAGA KESEHATAN PENDUKUNG ASI EKSKLUSIF
Authors: Ratnawati R , Kurniawati Trina , Kamalah Aisyah Dzil 
Published: February 2022

Abstract
Pemberian ASI Eksklusif sangat bermanfaat baik bagi ibu maupun bayi. Pemberian ASI Eksklusif juga menjadi salah satu program yang dicanangkan untuk menurunkan angka kematian dan kesakitan ibu dan bayi baru lahir. Tujuan pengabdian masyarakat ini adalah untuk meningkatkan pengetahuan tenaga kesehatan terhadap pelaksanaan konseling menyusui. Program ini dilaksanakan dengan menyelenggarakan kerjasama antara jajaran pimpinan RSUD Kajen. Pelaksanaan pelatihan yang terdiri dari penyampaian materi terkait ASI Eksklusif dan teori konseling dan dilanjutkan dengan praktik konseling yang dilakukan setiap peserta secara berpasangan. Sesi akhir, peserta diberikan soal post test. Jumlah peserta adalah 31 tenaga kesehatan yang bertugas di ruang maternal. Uji statistik yang digunakan adalah dengan uji T test. Hasil pelatihan didapatkan ada pengaruh pemberian pelatihan konseling menyusui dengan tingkat pengetahuan peserta dengan nilai p value 0,001. Pengetahuan dan kemampuan manajemen laktasi dan konseling menyusui bagi tenaga kesehatan teruatama yang bertugas di Rumah sakit sangat penting karena tenaga kesehatan ini merupakan kontak pertama ibu dan bayi setelah melahirkan.
Kata kunci: ASI Eksklusif, Pelatihan Konseling Menyusui, Tenaga Kesehatan

Abstract
[BREASTFEEDING COUNSELING TRAINING FOR EXCLUSIVE BREASTFEEDING SUPPORTING GROUP : HEALTH WORKER] Exclusive breastfeeding is very beneficial for both mother and baby. Exclusive breastfeeding is also one of the programs launched to reduce maternal and newborn mortality and morbidity. The purpose of this community service is to increase the knowledge of health workers on the implementation of breastfeeding counseling. This program is implemented by organizing cooperation between the leadership ranks of the Kajen Hospital. implementation of the training consisting of the delivery of material related to exclusive breastfeeding and counseling theory and continued with counseling practices carried out by each participant in pairs. In the final session, participants were given post test questions. The number of participants is 31 health workers who work in the maternal room. The statistical test used is the T test. The results of the training showed that there was an effect of providing breastfeeding counseling training with the level of knowledge of the participants with a p value of 0.001. Knowledge and ability of lactation management and breastfeeding counseling for health workers, especially those who work in hospitals, are very important because these health workers are the first contact between mothers and babies after giving birth.
Keywords: Breastfeeding Counseling Training, Exclusive Breastfeeding, Health Workers.
Philosophy After Deleuze
Authors: Hughes Joe 
Published: February 2022

Philosophy After Deleuze is a bold, wide-ranging and informative book. Joe Hughes affirms unequivocally that there is a Deleuzian philosophy and then shows us how to find it despite the many changes in subject matter and vocabulary that characterize Deleuze's work. He traces the outlines of a Deleuzean philosophy across key manifestations in the fields of ontology, ethics, aesthetics and politics. He provides insightful accounts of Deleuze's engagements with familiar interlocutors such as Kant, Spinoza, Bergson and Nietzsche, but also his less studied engagements with figures such as Blanchot, Klossowski and Hume. This book is essential reading for every serious student of Deleuze.' -- Paul Patton, Professor of Philosophy at the University of New South Wales, Australia
Philosophy After Deleuze is a superb book that picks up where Hughes's earlier book, Deleuze and the Genesis of Representation, left off. It presents Deleuze as a systematic philosopher in a Kantian vein, arguing persuasively that one of the aims of Deleuze's work was to carry the Kantian initiative in philosophy to its completion. Hughes deftly works out the implications of this claim in four domains that closely reflect the architectonic structure of Kant's own philosophy: ontology, aesthetics, ethics, and politics. Hughes writes with admirable clarity, which makes his book both an accessible introduction to Deleuze's thought as well as a challenging reevaluation for more advanced readers. Highly recommended. -- Daniel Smith, Associate Professor of Philosophy at Purdue University, USA Published On: 2013-02-04
Joe Hughes does an excellent job not only of introducing the reader to what Deleuze thought but, more importantly, why he thought and expressed himself as he did... The clear and persuasive way in which he deals with the complexities of Deleuze’s style sets the tone... Hughes is effective in synthesizing and presenting complex ideas in an uncluttered and precise way... A first-rate introduction for those who, from advanced undergraduate level up, are approaching Deleuze’s thought and style for the first time. -- Christopher Watkin, Monash University — Oxford Journals Published On: 2013-07-01
This book is ... a very clear and didactic introduction to Deleuze himself. — Tijdschrift voor Filosofie (Bloomsbury Translation).
Inquiry into the Beauties of Painting
Authors: Webb Daniel 
Published: February 2022

Daniel Webb (1719?-98) was an Irish writer, critic and theorist, born in Limerick and studied at Oxford. He was the author of three seminal treatises on aesthetics: An Inquiry into the Beauties of Painting (1760), Remarks on the Beauties of Poetry (1762), and Observations on the Correspondence Between Poetry and Music(1769). Reflecting a trend in theoretical discourses of the period, An Inquiry into the Beauties of Painting (1760) is arranged as a dialogue, set out as case ‘A’ and ‘B’. Topics range from ‘Our Capacity to Judge of Painting’ and ‘The Antiquity and Usefulness of Painting’ to ‘Of Design’, ‘Of Colouring’, ‘Of the Clear Obscure’ and ‘Of Composition’. In the final Dialogue, Webb demonstrates his preference for Raphael and Leonardo da Vinci’s classicalism over the Baroque style of 17th century artists, such as Lanfranc and Pietro di Cortona.
This work and many of his theories of art are considered to be informed by his trip to Rome, where he met his portrait painter and artist Anton Raffael Mengs (1728-79). Mengs granted Webb access to his unpublished manuscript Gedanken über die Schönheit (1762), or ‘Thoughts on Beauty’. German theorist Johann Joachim Winckelmann (1717-1768) later accused Webb of plagiarism, citing the similarities of An Inquiry into the Beauties of Painting in terms of its assessment of Raphael. Nevertheless, three editions translated into German were published in 1771.
Nietzsche and Philosophy
Authors: Deleuze Gilles 
Published: February 2022

Gilles Deleuze (1925-1995) was Professor of Philosophy at the University of Paris VIII. He is a key figure in poststructuralism, and one of the most influential philosophers of the twentieth century.
Nietzsche and Philosophy has long been recognised as one of the most important accounts of Nietzsche's philosophy, acclaimed for its rare combination of scholarly rigour and imaginative interpretation. Yet this is more than a major work on Nietzsche; the book opened a whole new avenue in post-war thought. Here, Deleuze shows how Nietzsche began a new way of thinking which breaks with the dialectic as a method and escapes the confines of philosophy itself.
Translated by Hugh Tomlinson.
KHẢO SÁT CÁC CHỈ SỐ ALBUMIN – BILIRUBIN Ở BỆNH NHÂN XƠ GAN CÓ UNG THƯ BIỂU MÔ TẾ BÀO GAN
Authors: Công Long Nguyễn , Thị Phương Đàm 
Published: February 2022

Mục tiêu: Bệnh nhân ung thư biểu mô tế bào gan (HCC) thường xuất hiện trên nền gan xơ. Nghiên cứu chúng tôi với mục tiêu áp dụng phân loại albumin-bilirubin (ALBI) trong đánh giá chức năng gan. Đối tượng và phương pháp: Trong nghiên cứu chúng tôi tuyển chọn được 224 bệnh nhân HCC từ năm 2018-2019 tất cả bệnh nhân được tính toán chỉ số ALBI và phân loại Child-Pugh, phân loại Barcelona (BCLC). Kết quả: Tổng số 224 bệnh nhân HCC (186 nam và 38 nữ, tuổi trung bình, 28 – 90 tuổi, trung bình là 59 tuổi) được đánh giá chỉ số ALBI. Bệnh nhân HCC được phân chia giai đoạn theo BCLC giai đoạn A (20.2%), BCLC giai đoạn B (45.7%), BCLC giai đoạn C (23.8%) và giai đoạn D (10.3%). Điểm Child-Pugh và phân loại theo ALBI và BCLC có sự tương đồng về mức độ giai đoạn. Kết luận: Nghiên cứu cho thấy rằng chỉ số albumin-bilirubin (ALBI) là một yếu tố có khả năng dự báo chức năng gan theo phân loại Child-pugh và BCLC ở bệnh nhân HCC.
ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ VIÊM TỦY KHÔNG HỒI PHỤC MỘT THÌ CÓ HỖ TRỢ LASER DIODE
Authors: Hồng Lợi Nguyễn , Hồ Phương Mai Nguyễn 
Published: February 2022

Mục tiêu: Khảo sát đặc điểm lâm sàng, X-quang và đánh giá kết quả điều trị viêm tủy không hồi phục một thì có hỗ trợ Laser diode. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả tiến cứu, có can thiệp lâm sàng, trên 35 với 38 răng, tuổi từ 10 đến 70, được chẩn đoán và điều trị hoại tử tủy. Đánh giá kết quả sau trám bít ống tủy, sau điều trị 1 ngày, 1 tuần và 3 tháng. Kết quả: Kết quả lâm sàng sau điều trị 1 ngày: không đau chiếm 60,5%, không có trường hợp nào đau nặng trở lên; sau điều trị 1 tuần: Tốt: 94,7%; sau điều trị 1 tháng: Tốt 97,4%. Kết quả X quang sau sửa soạn và trám bít ống tủy: Tốt: 92,1%; sau 3 tháng: Tốt: 94,7%.Không có trường hợp kém về lâm sàng và X quang. Kết luận: Sử dụng laser diode trong điều trị viêm tủy không hồi phục 1 thì nên được áp dụng vì đây là điều trị hỗ trợ đơn giản, ít xâm lấn và có hiệu quả.