bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ineligible, Unaware, or Uninterested? Associations Between Underrepresented Patient Populations and Retention in the Pathway to Cancer Clinical Trial Enrollment
Authors: Caston Nicole E. , Lalor Fallon , Wall Jaclyn , Sussell Jesse , Patel Shilpen , Williams Courtney P. , Azuero Andres , Arend Rebecca , Liang Margaret I. , Rocque Gabrielle B. 
Published: September 2022

PURPOSE: Cancer clinical trials can benefit current and future patients; however, Black patients, rural residents, and patients living in disadvantaged areas are often underrepresented. Using an adapted version of Unger and colleagues' model of the process of clinical trial enrollment, we evaluated the relationship between underrepresented patient populations and trial end points. METHODS: This retrospective study included 512 patients with breast or ovarian cancer who were prescribed a therapeutic drug at the University of Alabama at Birmingham from January 2017 to February 2020. Patient eligibility was assessed using open clinical trials. We estimated odds ratios and 95% CIs using logistic regression models to examine the relationship between underrepresented patient populations and trial enrollment end points: eligibility, interest, offer, enrollment, and declining enrollment. RESULTS: Of the patients in our sample, 27% were Black, 18% were rural residents, and 19% lived in higher disadvantaged neighborhoods. In adjusted models, each comparison group had similar odds of being eligible for a clinical trial. Black versus White patients had 0.40 times the odds of interest in clinical trials and 0.56 times the odds of enrollment. Patients living in areas of higher versus lower disadvantage had 0.46 times the odds of enrolling and 3.40 times the odds of declining enrollment when offered. CONCLUSION: Eligibility did not drive clinical trial enrollment disparities in our sample; however, retention in the clinical trial enrollment process appears to vary by group. Additional work is needed to understand how interventions can be tailored to each population's specific needs.
Rousseau on the Île Saint-Pierre
Authors: Abele Célia 
Published: September 2022

Abstract
This essay shows that the pre-Romantic conception of the late Rousseau as alone in nature has led to misunderstandings of the project of the Rêveries du promeneur solitaire as an exclusively solipsistic text about Rousseau’s self turning inward. Focusing on the central “Fifth Promenade” of the Rêveries, this article argues that, on the contrary, it is an early enactment of the literary realism of the nineteenth-century novel that faces outward by describing both society and nature. The article shows how society and the state are included within its narrative, which employs several features typical of realism. The presence of details describing the natural and social environment is linked to how the “Promenade” centers his scientific attention to plant life on the island. That fact points to the deep epistemological connection between science and realism. Rousseau’s text, which is explicitly bound up with his practice of collecting plants to preserve them in herbaria, achieves this through an epistemology of synecdoche and the microcosm that makes it possible to move between part and whole.
History at the Roundabout
Authors: Reid Donald 
Published: September 2022

Abstract
The Gilets jaunes brought attention to the existence and demands of the popular classes as other than the deplorables of the far right. This essay examines the ideas of an innovative group of historians who interpret the Gilets jaunes as evoking and enacting the unresolved issues of the revolutions of 1789, 1848, and 1871 on the nature and practice of democracy in France.
Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons
Authors: De Gregorio Roberto , Subah Galadu , Chan Jennifer C. , Speranza Luisa , Zhang Xiaolei , Ramakrishnan Aarthi , Shen Li , Maze Ian , Stanton Patric K. , Sze Ji Y. 
Published: September 2022

ABSTRACT
Neurodevelopmental disorders ranging from autism to intellectual disability display sex-biased prevalence and phenotypical presentations. Despite increasing knowledge about temporospatial cortical map development and genetic variants linked to neurodevelopmental disorders, when and how sex-biased neural circuit derailment may arise in diseased brain remain unknown. Here, we identify in mice that serotonin uptake transporter (SERT) in non-serotonergic neurons – hippocampal and prefrontal pyramidal neurons – confers sex-biased effects specifically during neural circuit development. A set of gradient-patterned CA3 pyramidal neurons transiently express SERT to clear extracellular serotonin, coinciding with hippocampal synaptic circuit establishment. Ablating pyramidal neuron SERT (SERTPyramidΔ) alters dendritic spine developmental trajectory in the hippocampus, and precipitates sex-biased impairments in long-term activity-dependent hippocampal synaptic plasticity and cognitive behaviors. Transcriptomic analyses identify sex-biased alterations in gene sets associated with autism, dendritic spine structure, synaptic function and male-specific enrichment of dysregulated genes in glial cells in early postnatal SERTPyramidΔ hippocampus. Our data suggest that SERT function in these pyramidal neurons underscores a temporal- and brain region-specific regulation of normal sex-dimorphic circuit development and a source for sex-biased vulnerability to cognitive and behavioral impairments.
This article has an associated ‘The people behind the papers’ interview.
preCICE v2: A sustainable and user-friendly coupling library
Authors: Chourdakis Gerasimos , Davis Kyle , Rodenberg Benjamin , Schulte Miriam , Simonis Frédéric , Uekermann Benjamin , Abrams Georg , Bungartz Hans-Joachim , Cheung Yau Lucia , Desai Ishaan , Eder Konrad , Hertrich Richard , Lindner Florian , Rusch Alexander , Sashko Dmytro , Schneider David , Totounferoush Amin , Volland Dominik , Vollmer Peter , Koseomur Oguz Ziya 
Published: September 2022

preCICE is a free/open-source coupling library. It enables creating partitioned multi-physics simulations by gluing together separate software packages. This paper summarizes the development efforts in preCICE of the past five years. During this time span, we have turned the software from a working prototype -- sophisticated numerical coupling methods and scalability on ten thousands of compute cores -- to a sustainable and user-friendly software project with a steadily-growing community. Today, we know through forum discussions, conferences, workshops, and publications of more than 100 research groups using preCICE. We cover the fundamentals of the software alongside a performance and accuracy analysis of different data mapping methods. Afterwards, we describe ready-to-use integration with widely-used external simulation software packages, tests, and continuous integration from unit to system level, and community building measures, drawing an overview of the current preCICE ecosystem.
Study protocol for evaluating the clinical efficacy and neurobiological correlates of sequential treatment with tDCS primed iTBS and ECT in treatment-resistant depression
Authors: Sinha Preeti , Shreekantiah Umesh , Goyal Nishant , Sreeraj Vanteemar Sathyanarayana , Arumugham Shyam Sundar , Samantaray Subham , Jammigumpula Ashok , Nanjundaiah Gopala Krishna Kadarapura , Venkataramaiah Sudhir , Thennarasu Kandavel , Roy Chandramouli , Purohith Abhiram Narasimhan , Shenoy Sonia , Kumar Channaveerachari Naveen , Shivakumar Venkataram , Udupa Kaviraj , Muralidharan Kesavan , Venkatasubramanian Ganesan , Thirthalli Jagadisha , Praharaj Samir Kumar , Mehta Urvakhsh Meherwan 
Published: September 2022

Background: Treatment-resistant depression is a burdensome condition. Intermittent theta burst stimulation (iTBS) of the left dorsolateral prefrontal cortex is considered a treatment option in early course of resistance with a proportion of such patients responding to it. Preliminary evidence suggests a role of priming iTBS stimulation with preconditioning using cathodal transcranial direct current stimulation (tDCS). This protocol describes a double-blind randomized sham-controlled study to evaluate the clinical efficacy and tolerability of tDCS-primed iTBS in the treatment of resistant depression. Non-responders to this trial will be offered open-label electroconvulsive therapy. All participants will undergo neurobiological investigations that will enable the identification of potential response predictors and mechanisms. Methods: Three hundred and fifty consenting patients with treatment resistant depression will be randomly assigned to receive 20–30 daily sessions of true-tDCS or sham-tDCS primed iTBS over left dorsolateral prefrontal cortex at three study centers. After this blinded sham-controlled trial, non-responders to the intervention will be offered open-label true ECT. Clinical assessments, neurocognitive assessments and multimodal investigations (magnetic resonance imaging, electroencephalography, heart rate variability, investigative transcranial magnetic stimulation-transcranial direct current stimulation, gene polymorphisms) will be conducted at baseline and repeated after the end of the trial, as well as open-label ECT course. The trial will evaluate the improvement in depressive symptoms (Hamilton depression rating scale) between the two groups as the primary outcome measure.
Research of changes in the level of vascular endothelial growth factor in experimental diabetic retinopathy. comparison of methods of correction
Authors: Sirman Ya. , Savytskyi I. 
Published: September 2022

The aim of work to investigate the changes in the vascular endothelium growth factor in experimental animals, which were simulated diabetic retinopathy and against the background of its correction.
The results of the analysis of the vascular growth factor in the 2nd group confirm the development of diabetic retinopathy, a particularly pronounced increase in the marker was detected on the 180th day of the development of the pathological process. It was established analyzing the data of group No. 3 that the correction of the pathological condition with hypoglycemic agents has partial positive effect but requires the involvement of additional means of correction in addition to the normalization of the level of glycemia. The results of the 4th group indicate that the involvement of a nitric oxide donor and aflibercept in the correction of diabetic retinopathy has positive effect on the reduction of the level of vascular growth factor, more pronounced compared to the 3rd group, but it does not reach normative values. It is observed that the correction of the simulated pathological condition by reducing hyperglycemia, administration of aflibercept and bromfenac (group No. 5) gives positive results, but less pronounced, compared to the data of the 4th group.
It was found that in rats in which diabetic retinopathy was modeled with subsequent correction of hyperglycemia, administration of aflibercept, L-carnitine and bromfenac (group No. 6) at the first stage, there is a pronounced effectiveness of the proposed method of correction in comparison with the previously considered methods, the established positive trend is being followed also at the 2nd and 3rd stages of the experiment, which indicates the effectiveness of this correction method.
The most pronounced positive effect of normalizing the level of vascular growth factor is observed when using a hypoglycemic drug in combination with the administration of aflibercept, a solution of L-arginine and citicoline (in group No. 7).
Flight to Earnings: The Role of Earnings in Periods of Capital Scarcity
Authors: Guest Nick , Kothari S. P. , So Eric 
Published: September 2022

We examine the link between the scarcity of arbitrage capital and investors’ response to firms’ earnings information. The cost of financing levered investment strategies (i.e., investing with borrowed funds) increases in the risk profile of the securities being traded. As a result, when capital is scarce, levered traders face heightened incentives to tilt their portfolios in the direction of firms’ earnings information as an indicator of lesser risk because doing so mitigates financing constraints. Our results suggest that these investors become more responsive to firms’ earnings announcements when capital is scarce. Moreover, market prices display a stronger reaction to firms’ announcements and less postearnings announcement drift. Together, our findings suggest the scarcity of arbitrage capital spurs both the use of and responsiveness of market prices to firms’ earnings news. This paper was accepted by Brian Bushee, accounting. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4538 .
Contextual Bandits with Cross-Learning
Authors: Balseiro Santiago , Golrezaei Negin , Mahdian Mohammad , Mirrokni Vahab , Schneider Jon 
Published: September 2022

In the classic contextual bandits problem, in each round t, a learner observes some context c, chooses some action i to perform, and receives some reward [Formula: see text]. We consider the variant of this problem in which in addition to receiving the reward [Formula: see text], the learner also learns the values of [Formula: see text] for some other contexts [Formula: see text] in set [Formula: see text], that is, the rewards that would be achieved by performing that action under different contexts [Formula: see text]. This variant arises in several strategic settings, such as learning how to bid in nontruthful repeated auctions, which has gained a lot of attention lately as many platforms have switched to running first price auctions. We call this problem the contextual bandits problem with cross-learning. The best algorithms for the classic contextual bandits problem achieve [Formula: see text] regret against all stationary policies, in which C is the number of contexts, K the number of actions, and T the number of rounds. We design and analyze new algorithms for the contextual bandits problem with cross-learning and show that their regret has better dependence on the number of contexts. Under complete cross-learning in which the rewards for all contexts are learned when choosing an action, that is, set [Formula: see text] contains all contexts, we show that our algorithms achieve regret [Formula: see text], removing the dependence on C. For any other cases, that is, under partial cross-learning in which [Formula: see text] for some context–action pair of (i, c), the regret bounds depend on how the sets [Formula: see text] impact the degree to which cross-learning between contexts is possible. We simulate our algorithms on real auction data from an ad exchange running first price auctions and show that they outperform traditional contextual bandit algorithms. Supplemental Material: The online appendix is available at https://doi.org/10.1287/moor.2022.1313 .
Advertising Cycling to Manage Exclusivity Loss in Fashion Styles
Authors: Bruce Norris I. , Krishnamoorthy Anand , Prasad Ashutosh 
Published: September 2022

How Should Fashion Brands Use Advertising to Increase Sales while Remaining Exclusive? Fashion consumption signals a consumer’s status to the broader population, so fashion brands and their consumers value exclusivity. Consequently, fashion advertising must balance sales generation with exclusivity loss. In this paper, we develop a model with these features of fashion and estimate it using advertising, price, and sales data for two styles of handbags and sunglasses. Our analysis provides insights for advertising budgeting and scheduling and finds that advertising optimally should decrease as the product increases in popularity and vice versa. This exerts a braking force on sales oscillations so that the fashion cycle decays as does the optimal advertising path. In addition to demonstrating how advertising cycling can impact a fashion firm’s profitability, we show how different styles of a fashion brand can cycle at different rates. By connecting advertising cycles to fashion cycles, we provide prescriptions for how fashion firms should manage different styles of the same brand.
Thermal comfort during emergency transport by ambulance services
Authors: Gaumont Damien F 
Published: September 2022

Background: Cold is an unpleasant sensation and is linked to increased anxiety, pain and risk of hypothermia. A question was developed to test the authors' hypothesis that patients would feel cold while being transported to an Irish emergency department (ED) by the Ambulance Service (NAS). Method: A survey of a convenience sample of 96 respondents was undertaken, for 77 consecutive hours in March 2020 at University Hospital Limerick's ED. During that period, the NAS transported 163 patients to the ED. A seven-point Likert satisfaction rating scale was used to assess perception. Taking this in combination with a visual assessment of personal insulation and the vehicle's patient compartment heater status, this project endeavoured to determine the passengers' thermal comfort. Results: Fifty-three per cent of the sample (n=51) were women, 22% (n=21) were escorts and 78% (n=75) were patients. Forty-two patients (56%) were aged >65 years. Of those interviewed, 66.6% (n=64) rated 0 (neutral/comfortable/I didn't notice) at the beginning of their journey and 67.7% (n=65) rated 0 at the end of their journey. Thirteen reported finding the ambulance cold at the beginning of their journey, and five reported still being cold at the end of it. In contrast, 15 respondents found the ambulance warm. The vehicle's patient compartment heater was switched on in 80% (n=69) of the 86 journeys. Transportation had a median time of 27.5 minutes (range: 3–90 minutes). The recorded air temperature at the nearest weather station ranged between −0.8°C and 10.1°C, significantly lower than the average for the time of the year. Conclusions: During this relatively cold week, two-thirds of passengers rated their thermal comfort in the ambulance as comfortable, 15 were warm beyond comfortable and very few felt cold.
The impact of COVID-19 on mortality after hip fracture
Authors: Holleyman Richard J. , Khan Sameer K. , Charlett Andre , Inman Dominic S. , Johansen Antony , Brown Colin , Barnard Sharmani , Fox Sebastian , Baker Paul N. , Deehan David , Burton Paul , Gregson Celia L. 
Published: September 2022

Aims Hip fracture commonly affects the frailest patients, of whom many are care-dependent, with a disproportionate risk of contracting COVID-19. We examined the impact of COVID-19 infection on hip fracture mortality in England. Methods We conducted a cohort study of patients with hip fracture recorded in the National Hip Fracture Database between 1 February 2019 and 31 October 2020 in England. Data were linked to Hospital Episode Statistics to quantify patient characteristics and comorbidities, Office for National Statistics mortality data, and Public Health England’s SARS-CoV-2 testing results. Multivariable Cox regression examined determinants of 90-day mortality. Excess mortality attributable to COVID-19 was quantified using Quasi-Poisson models. Results Analysis of 102,900 hip fractures (42,630 occurring during the pandemic) revealed that among those with COVID-19 infection at presentation (n = 1,120) there was a doubling of 90-day mortality; hazard ratio (HR) 2.09 (95% confidence interval (CI) 1.89 to 2.31), while the HR for infections arising between eight and 30 days after presentation (n = 1,644) the figure was greater at 2.51 (95% CI 2.31 to 2.73). Malnutrition (1.45 (95% CI 1.19 to 1.77)) and nonoperative treatment (2.94 (95% CI 2.18 to 3.95)) were the only modifiable risk factors for death in COVID-19-positive patients. Patients who had tested positive for COVID-19 more than two weeks prior to hip fracture initially had better survival compared to those who contracted COVID-19 around the time of their hip fracture; however, survival rapidly declined and by 365 days the combination of hip fracture and COVID-19 infection was associated with a 50% mortality rate. Between 1 January and 30 June 2020, 1,273 (99.7% CI 1,077 to 1,465) excess deaths occurred within 90 days of hip fracture, representing an excess mortality of 23% (99.7% CI 20% to 26%), with most deaths occurring within 30 days. Conclusion COVID-19 infection more than doubles the rate of early hip fracture mortality. Those contracting infection between 8 and 30 days after initial presentation are at even higher mortality risk, signalling the potential for targeted interventions during this period to improve survival. Cite this article: Bone Joint J 2022;104-B(10):1156–1167.
A comparison of osteoarticular allografts and allograft-prosthesis composites for reconstruction of the distal femur after resection of a bone tumour in childhood
Authors: Jamshidi Khodamorad , Bagherifard Abolfazl , Mirzaei Alireza 
Published: September 2022

Aims Osteoarticular reconstruction of the distal femur in childhood has the advantage of preserving the tibial physis. However, due to the small size of the distal femur, matching the host bone with an osteoarticular allograft is challenging. In this study, we compared the outcomes and complications of a resurfaced allograft-prosthesis composite (rAPC) with those of an osteoarticular allograft to reconstruct the distal femur in children. Methods A retrospective analysis of 33 skeletally immature children with a malignant tumour of the distal femur, who underwent resection and reconstruction with a rAPC (n = 15) or osteoarticular allograft (n = 18), was conducted. The median age of the patients was ten years (interquartile range (IQR) 9 to 11) in the osteoarticular allograft group and nine years (IQR 8 to 10) in the rAPC group (p = 0.781). The median follow-up of the patients was seven years (IQR 4 to 8) in the osteoarticular allograft group and six years (IQR 3 to 7) in the rAPC group (p = 0.483). Limb function was evaluated using the Musculoskeletal Tumor Society (MSTS) score. Results At final follow-up, the knee was unstable in 9/18 patients (50%) in the osteoarticular allograft group and 2/15 patients (13%) in the rAPC group (p = 0.026). The median range of motion (ROM) of the knee was 117° (IQR 115° to 120°) in the osteoarticular allograft group and 100° (IQR 95° to 105°) in the rAPC group (p < 0.001). The median MSTS score was 25 (IQR 23 to 26) in the osteoarticular allograft group and 28 (IQR 26 to 29) in the rAPC group (p = 0.007). Osteoarthritic change was detected in 11/18 patients (61%) in the osteoarticular allograft group and in 4/15 (26%) patients in the rAPC group (p = 0.048). Conclusion In our series, a resurfaced allograft-prosthesis composite provided better knee stability and function, with a lower rate of osteoarthritis; an osteoarticular allograft was associated with better knee ROM. Cite this article: Bone Joint J 2022;104-B(10):1174–1179.