bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desenvolvimento de um jogo educacional de realidade mista voltado para o ensino médico:
Authors: De la Torre Prado Pereira Érica , Thais Schneider Bianca , Borges Benedetti Carolina , Molinari Bottega Luiza , Ventura Penteado da Silva Luiza , Alberton da Silva Rodrigo , Lazaretti Zanatta Alexandre , Santiago Pablo 
Published: February 2022

Introdução: A fim de aliar a educação médica com as novas tecnologias, iniciou-se o projeto de desenvolver um jogo educacional. Este jogo sério utilizou a tecnologia de realidade mista aplicada na área de hematologia. O jogo foi desenvolvido por dez estudantes de medicina em conjunto com uma mestranda e um acadêmico de ciências da computação, e tem como objetivo analisar a eficiência no processo de ensino.
Relato: O projeto iniciou com uma revisão de literatura dos jogos sérios já existentes e sua aplicação no ensino. Após, o grupo foi dividido e alguns alunos cuidaram da parte do roteiro e programação do jogo, outros da parte clínica da anemia e outros estudaram sobre a parte pedagógica e possíveis avaliações do aprendizado. Também, ao final da elaboração do jogo, desenvolveu-se protocolos de testagem com questionários validados e no momento o jogo encontra-se em fase de testes na disciplina de hematologia.
Discussão: A experiência evidenciou ainda mais a importância da interdisciplinaridade na educação médica, já maioria das escolas médicas ainda se possui um modelo de educação engessado e pouco criativo. Além disso, possibilitou a introdução de uma nova abordagem educacional e de uma nova tecnologia no modelo tradicional de ensino.
Conclusão: Portanto, nosso trabalho serviu para iniciar o contato entre duas áreas distintas dentro da universidade e estimular a produção de novas ferramentas de ensino, agregando ao currículo médico uma nova abordagem pedagógica. Por fim, instigou-se sobre o ensino complementado pelas ferramentas tecnológicas e novos jogos já estão sendo desenvolvidos seguindo o modelo proposto por este projeto.
Desarrollo aplicativo móvil para la gestión de pedidos en las PYMES - caso de estudio fábrica de pintura Induber
Authors: Vásquez Pérez Diana Marcela , Chilito Sandoval Michel , Mora Pedreros Tania Isadora 
Published: February 2022

El presente artículo plantea una solución a la automatización de procesos para las PYMES que actualmente se encuentran en una etapa o fase de apertura, aquellas que nacen en muchos casos de ideas familiares que desean entrar en emprendimiento y lograr así su proyección en el mercado. Tomando como base este contexto, existen muchas microempresas que, debido a su falta de experiencia, manejo y gestión de la información, realizan sus procesos de manera convencional, de ahí que sus procesos sean manuales y consignados en papel en un gran porcentaje.
El desarrollo de esta aplicación se enfoca principalmente a la automatización del proceso de gestión de pedidos, parte fundamental en toda PYMES. Para resolver la problemática existente se optó por el desarrollo de un aplicativo móvil empleando nuevas tecnologías con fácil acceso a clientes, empleados y administradores, permitiendo con esto que dichas empresas logren una mayor proyección y puedan entrar en el mercado de una manera más agradable para sus clientes.
Para el desarrollo de la aplicación se utilizó la metodología ICONIX, la cual realiza los avances del proyecto mediante fases que se componen de unos artefactos específicos para lograr un desarrollo adecuado, rápido y eficiente.
Low-dose Preoperative Unshielded Radiation Is Effective in Heterotopic Ossification Prophylaxis and Does Not Affect Porous Fixation in Total Hip Arthroplasty at 2 Years Minimum Follow-up: A Radiographic Study
Authors: Hanna Maged , Farid Yasser R. , Finn Henry A. 
Published: February 2022

Background:
Heterotopic ossification (HO) is a frequent complication of total hip arthroplasty (THA). HO can cause pain, limitation of range of motion, and instability. Radiation therapy (RT) for HO prophylaxis is well established but may interfere with early porous ingrowth and pullout strength of implants, as suggested by two animal studies. Although shielding of the bone from irradiation may theoretically protect ingrowth, it has been found to reduce RT effectiveness. Despite the popularity of porous implants in THA, the frequency of HO, and use of RT in its prophylaxis, the effect of RT on porous implant fixation in THA has not been previously reported. At our institution, we use unshielded, single-dose, preoperative 700 to 800 centigrays RT for HO prophylaxis in high-risk patients. We hypothesize that this RT protocol is effective and the press-fit technique protects porous implants during early ingrowth; therefore, long-term implant fixation is not compromised.

Methods:
This was a retrospective study aiming to determine fixation of porous THA implants, healing of trochanteric osteotomies, and efficacy of HO prophylaxis with this RT protocol.

Results:
Thirty-nine patients with follow-up of 24 to 144 months (average 59.7 months) were included. All 26 porous-coated femoral implants (11 revisions and 15 primary) were well fixed. There were 33 porous-coated acetabular implants (18 revisions and 15 primary). Thirty (91%) were well fixed, and three revision implants (9%) demonstrated radiolucent lines in two zones, but patients were clinically asymptomatic. All nine trochanteric osteotomies healed uneventfully. RT provided effective HO prophylaxis in 33 of 39 hips (85%).

Conclusions:
Single, low-dose, preoperative RT without shielding does not increase aseptic loosening of porous implants manufactured with plasma porous spray or nonunion of extended trochanteric osteotomies. This protocol provides effective HO prophylaxis in high-risk patients undergoing primary and revision THA.
Effect of Remote Proctoring of the Orthopaedic In-training Examination on Scores
Authors: Wongworawat M. Daniel , Incrocci Maria , Crumlish Christina Fulgaro , Klena Joel 
Published: February 2022

Introduction:
The pandemic has created an opportunity to explore different testing settings. However, transitioning to remote testing raises concerns about cheating. The possibility of cheating raises concern about the integrity of test psychometrics. In 2020, the orthopaedic in-training examination (OITE) was offered using two administration models, with programs having the option to provide physically distanced, in-person, proctored testing or remote testing and online proctoring. We aimed to determine whether scores were higher when the OITE was administered and proctored remotely.

Methods:
Residents of allopathic programs from the 2020 administration of the OITE were included. The American Academy of Orthopaedic Surgeons database of examinees and deidentified aggregate scores were compared. The primary outcome variable was the number of items answered correctly. Of 275 questions and after psychometric analysis, eight questions were excluded, leaving 267 questions as the denominator for percent correct. The mean number of items answered correctly was compared between the group with in-person proctoring and the group with virtual, digital proctoring using the two-sample Student t-test.

Results:
A total of 4405 examinees consisted of two cohorts: 1834 residents (42%) took the OITE with in-person proctoring and 2571 residents (58%) completed the test in the remote testing and proctoring models. No difference in mean scores was observed between in-person proctored and remotely proctored examinees (in-person: 162.98 ± 21.11, remote: 162.22 ± 22.04, mean difference: −0.75 [95% CI, −2.04 to 0.53]; P = 0.25).

Discussion:
Remote testing with virtual proctoring has become more widely used. There was no difference in scores and no evidence of enough cheating to change the “curve” of the OITE. Knowing that there was no evidence of sufficient cheating to change overall test psychometrics, programs and residents can be reassured that the OITE remains a valid educational instrument even when administered remotely.
Pengaruh Penggunaan Teknik Ice Breaking terhadap Hasil Belajar Matematika Siswa Sekolah Dasar
Authors: Pujiarti Titi 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan teknik Ice Breaking terhadap hasil belajar matematika siswa kelas V SDN Mpuri. Penelitian ini merupakan penelitian ekspeerimen dengan rancangan kelompok non ekuivalen. Populasi penelitian ini merupakan seluruh siswa SDN Mpuri yang berjumlah 120 siswa. Sampel diambil menggunakan desain Pre Experimental Design bentuk One Group Pretest Postest Design. Sampel dalam penelitian ini adalah siswa kelas V SDN Mpuri dengan jumlah 30 siswa. Metode pengumpulan data yang digunakan adalah metode tes berbentuk tes uraian. Teknik analisis data yang digunakan adalah uji-t. Hasil analisis uji-t menunjukkan tingkat signifikansi 0,0170,05 menunjukkan bahwa terdapat perbedaan signifikan sebelum dan sesudah pemberian treatment. Sehingga H0 diterima dan Ha ditolak, artinya ada pengaruh penerapan teknik Ice Breaking terhadap hasil belajar matematika pada siswa kelas V SDN Mpuri.
MODEL PEMBANGUNAN HUTAN DESA DI KELURAHAN LATUPPA KECAMATAN MUNGKAJANG KOTA PALOPO
Authors: Irawati Irawati , Jusuf Yusran , Muhammad Dassir 
Published: February 2022

Aktivitas masyarakat dalam kawasan hutanseperti penebangan liar dan alih fungsi hutan menjadi perkebunan mengakibatkan kerusakan hutan. Oleh karena itu diperlukan pengelolaan hutan oleh masyarakat secara lestari. Tujuan dari penelitianyaitu untuk mengetahui bentuk pemanfaatan hutan oleh masyarakat sekitar calon lokasi hutan desa dan merumuskan model pembangunan hutan desa di Kota Palopo. Metode penelitian yang digunakan melalui wawancara dengan menggunakan kuesioner dan survei lapangan. Analisis data dilakukan secara deskriptif kualitatif dan kuantitatif. Hasil menunjukkan bahwa ada dua macam pemanfaatan hutan oleh masyarakat yaituberkebun dan pemanfaatan hasil hutan bukan kayu. Tanaman yang dibudidayakan di lahan kebun yaitu kakao,cengkeh, buah-buahan dan tanaman kehutanan. Sedangkan Hasil hutan bukan kayu yang telah dimanfaatkan oleh Masyarakat yaitu nira aren, bambu, budidaya lebah, pala, kemiri dan buah-buahan serta jasa lingkungan pemanfaatan air bersih. Hasil hutan bukan kayu yang belum dimanfaatkan yaitu rotan dan potensi wisata yang cukup besar. Pemanfaatan rotan belum dilakukan karena masyarakat belum memiliki izin pemanfaatan. Model pembangunan desa yang cocok untuk Hutan Lindung Siguntu yaitu pemanfaatan secara maksimal hasil hutan bukan kayu dan pemanfaatan lahan yang rusak dengan penanaman tanaman MPTs seperti pala dan kemiri serta pemanfaatan air terjun sebagai potensiwisata alam
Intravenous Immunoglobulin Nonresponse in Pediatric Patients Treated for Kawasaki Disease at a US Hospital
Authors: Smelser Lauryn , Vejzovic Jennifer , Johnson Emma , Schultz Jordan , Wood Kelly E. 
Published: February 2022

OBJECTIVE
Kawasaki disease (KD) is an acute febrile childhood vasculitis with a predilection for the coronary arteries treated with IVIG. In the United States, scoring systems to identify children at high-risk of persistent fever after initial IVIG treatment are lacking. Our study attempts to identify variables associated with IVIG non-response.

METHODS
Retrospective review of patients ages 0 to 18 admitted to an US academic children's hospital between August 1, 2010, and August 31, 2019, with the diagnosis of acute KD who received IVIG during hospitalization.

RESULTS
A total of 64 patients were included, 73% male and 66% Caucasian with a mean age of 3.67 ± 3.35 years. Forty-eight patients (75%) received 1 dose of IVIG, and 16 (25%) received 2 doses of IVIG. The groups did not differ significantly at baseline. None had coronary artery aneurysms detected during hospitalization. Older age, female sex, Caucasian compared with African American race, leukocytosis, and hyponatremia were associated with a higher likelihood of IVIG non-response but none reached statistical significance. Patients who received ibuprofen (n = 26) were more likely to be IVIG non-responsive (p &lt; 0.05). Aspirin dosing varied but was not predictive of IVIG non-response.

CONCLUSIONS
In this study, risk factors to predict IVIG non-response in patients treated for KD were not identified. IVIG non-response was significantly more common in those receiving ibuprofen during the acute treatment phase. Larger studies are needed to validate the association of ibuprofen administration and IVIG non-response in patients with KD.
Implementation of Interprofessional Rounds Decreases Neonatal Abstinence Syndrome Length of Stay
Authors: McCarty Teri , Braswell Erica 
Published: February 2022

OBJECTIVE
Neonatal abstinence syndrome (NAS) occurs due to abrupt discontinuation of chronic fetal exposure to substances used by the mother during pregnancy. As the incidence of NAS continues to increase, medical teams are evaluating strategies to reduce length of stay (LOS). Increased LOS contributes to poorer mother-infant bonding and neurodevelopmental outcomes as well as increased health care cost. As part of an ongoing quality improvement project, the objective of this study was to determine if formal interprofessional rounds affected LOS for infants with NAS.

METHODS
This was a retrospective analysis at a single hospital system to determine if interprofessional rounds had an impact on NAS LOS. On February 5, 2016, introduction of formal weekly interprofessional NAS-specific rounds occurred in addition to daily patient care rounds. Every patient with opioid exposure undergoing Finnegan scoring, treated with weight-based morphine, and &gt;35 weeks gestation was included. Data were collected on LOS and length of therapy for eligible patients. This study evaluated the impact of interprofessional rounds on LOS 17 months after its implementation compared with 13 months immediately preceding.

RESULTS
Among the 119 infants (51 pre and 68 post) meeting inclusion criteria, the median LOS for the post-rounds group was significantly shorter than the pre-rounds group (13 vs 16 days, p = 0.001). The median length of therapy (morphine with or without clonidine) was also significantly shorter in the post-rounds versus the pre-rounds group (8 vs 12 days, p = 0.001).

CONCLUSIONS
Formal weekly interprofessional NAS rounds decreased LOS and length of therapy.
Shared Memory, Odours and Sociotransmitters or: "Save the Interaction!"
Authors: Candau Joël 
Published: February 2022

Collective memory, social memory, professional memory: although these notions are in current use when we name the shared (or assumed to be shared) representations of the past, they are very ambiguous. The point at issue is to show how memories can become common to some or to all members of a group. In this paper, I shall base my arguments on the simplest situation imaginable: The sharing of a memory of an olfactory experience by two individuals, namely one of my informants – a gravedigger – and myself.We can try to explain this shared olfactory memory, or the imagination of this sharing, by taking two facets into consideration. First of all, we must learn to take seriously those few seconds when a shared experience of the sensory world took shape between the anthropologist and his informant. Secondly, we must attempt to answer both of the following questions: what is the nature of this sharing? And what conditions make it possible? In the first part of this text, I examine the issue of the nature of sharing by weighing up its aspects as I consider protomemory, memory and metamemory. In the second part, I outline one of the essential conditions of sharing: the existence of what I call sociotransmitters. For the most part, my attention remains focused on that particular moment when the gravedigger said, “Smell this!”, and when what was at stake was to save the interaction.
Experiencing (Pereživanie) as Developmental Category: Learning from a Fisherman who is Becoming (as) a Teacher-in-a-Village-School
Authors: Jóhannsdóttir Thurídur , Roth Wollf-Michael 
Published: February 2022

In this study, we take up L. S. Vygotsky’s challenge to study learning and development in terms of categories, irreducible units that preserve the characteristics of the whole (society). One such category (unit) is experiencing [pereživanie], a process that integrates over the relation of person and environment. Using a case study from Iceland, we theorize the process of “becoming as a teacher-in-a-village school” in terms of experiencing [pereživanie]. The case describes a stage of development in the life of a person who becomes a teacher and then experiences a developmental trajectory very different from his previous life as a fisherman. This is an aspect of teacher education that is hardly (if ever) described in the teacher education literature which tend to be concerned with events after a person has entered a professional program or after a person has begun teaching. We discuss the implications of taking experiencing [pereživanie] as the developmental unit for theory and the practice of teacher education and development.
Empathic Actors Strengthen Organisational Immunity to Industrial Crisis: Industrial Actors’ Perception in Nepal
Authors: Bhattarai Raj Kumar 
Published: February 2022

This paper aims to understand the kind of activities that industrial actors develop in order to protect their enterprises during industrial crisis conditions. A series of political unrest, insurgency, economic turmoil, deadly earthquakes, and economic embargo at the Indo- Nepal boarder escalated the industrial crisis in Nepal. The quest for sustainability of enterprises during the enduring nature of the crisis stimulated for a more detail conversation and survey. A perceptual survey of industrial actors accompanying conversation therein indicates that trade union and association leaders develop positive attitude and advance specific activities for protecting their enterprises during industrial crisis conditions. The study finds that an empathic nature helps to develop a positive attitude among the industrial actors, which seems contributory for enterprises to survive during crisis conditions. The actors tend to positively perceive significance of specific activities under the conditions of difficulties and hardships and enhance immunity to the industrial crisis. This paper argues that the empathic nature of the industrial actors becomes more effective to safeguard the pluralistic interests of the stakeholders of the enterprise than the self- centric nature of the actors. The actors are not only engaged in safeguarding their claims on the industry but are also contributing—beyond their routine work—positively to strengthen the enterprise immunity during difficulties. This paper concludes with an insight of shifting managerial attention from the generic concepts like cost minimisation and product differentiation to the concepts of regularity in supply of goods and services in the business network by expanding the scope of industrial relations vertically and horizontally. The empathic nature of industrial actors enhances the effectiveness of the general system theory and social network theory by developing understanding of the role of industrial actors’ relations in sustaining and operationalizing a business network under organizational crisis conditions.
Compensation of Intellectual Disability in a Relational Dialogue on Down Syndrome
Authors: Souza Fabiola Ribeiro de , Souza Fabiola Ribeiro de , Barbato Silviane Bonaccorsi 
Published: February 2022

The historical-cultural theory of Intellectual Disability (DI) overcompensation/compensation is referenced in several studies, but little empirical evidence is presented to corroborate this thesis. In this work, 13 current studies were analysed about the behavioural profile of people with Down syndrome (DS), a case of neurobiological ID, published in the last 15 years, in order to verify the possibility of dialogue with the theorizing about compensation. Despite contributing to an up to date understanding of DS, the results point to similarities between different scientific traditions allowing discussions regarding methodologies, data interpretation, language comprehension, and the impact of the studies for school inclusion and the development of people with ID/DS. It is concluded that the theorization in question is pertinent to developmental studies, dialogues with other perspectives and that its progress depends on investigations directed to the affective motivators/emotions of the person with ID/DS by means of more interpretative methodologies.
Keywords: Down syndrome, compensation, behavioural profile, Intellectual Disabilities Development
Nontargeted and targeted metabolomics approaches reveal the key amino acid alterations involved in multiple myeloma
Authors: Yue Lingling , Zeng Pengyun , Li Yanhong , Chai Ye , Wu Chongyang , Gao Bingren 
Published: February 2022

Purpose
Multiple myeloma (MM), a kind of malignant neoplasm of clonal plasma cells in the bone marrow, is a refractory disease. Understanding the metabolism disorders and identification of metabolomics pathways as well as key metabolites will provide new insights for exploring diagnosis and therapeutic targets of MM.

Methods
We conducted nontargeted metabolomics analysis of MM patients and normal controls (NC) using ultra-high-performance liquid chromatography (UHPLC) combined with quadrupole time-of-flight mass spectrometry (Q-TOF-MS) in 40 cases of cohort 1 subjects. The targeted metabolomics analysis of amino acids using multiple reaction monitoring-mass spectrometry (MRM-MS) was also performed in 30 cases of cohort 1 and 30 cases of cohort 2 participants, to comprehensively investigate the metabolomics disorders of MM.

Results
The nontargeted metabolomics analysis in cohort 1 indicated that there was a significant metabolic signature change between MM patients and NC. The differential metabolites were mainly enriched in metabolic pathways related to amino acid metabolism, such as protein digestion and absorption, and biosynthesis of amino acids. Further, the targeted metabolomics analysis of amino acids in both cohort 1 and cohort 2 revealed differential metabolic profiling between MM patients and NC. We identified 12 and 14 amino acid metabolites with altered abundance in MM patients compared to NC subjects, in cohort 1 and cohort 2, respectively. Besides, key differential amino acid metabolites, such as choline, creatinine, leucine, tryptophan, and valine, may discriminate MM patients from NC. Moreover, the differential amino acid metabolites were associated with clinical indicators of MM patients.

Conclusions
Our findings indicate that amino acid metabolism disorders are involved in MM. The differential profiles reveal the potential utility of key amino acid metabolites as diagnostic biomarkers of MM. The alterations in metabolome, especially the amino acid metabolome, may provide more evidences for elucidating the pathogenesis and development of MM.