bluuebunny/crossref_metadata_2025_split huggingface dataset:
Light pollution enhances ground‐level exposure to airborne toxic chemicals for nocturnally migrating passerines
Authors: La Sorte Frank A. , Lepczyk Christopher A. , Aronson Myla F. J. 
Published: October 2022

AbstractAnthropogenic activities generate different forms of environmental pollution, including artificial light at night (ALAN) and airborne toxic chemicals (ATCs). Nocturnally migrating birds are attracted to ALAN during migration and if ALAN occurs in unison with ATC, the chances of ground‐level ATC contamination occurring at stopover sites could increase. Here, we document the relationship between ALAN and ATC within the contiguous United States based on 479 toxic chemicals from 15,743 releasing facilities. Using weekly diurnal estimates of relative abundance for 165 nocturnally migrating passerine (NMP) bird species, we assess how the species richness and relative abundance of NMP species are correlated with ALAN and ATC across the annual cycle. The concentration of ATC increased with increasing ALAN levels, except at the highest ALAN levels. The species richness of NMP species was positively correlated with ATC during the non‐breeding season and migration, and negatively correlated during the breeding season. The relative abundance of NMP species was negatively correlated with ATC during the breeding and non‐breeding seasons and the correlation did not differ from zero during migration. Through the disorienting influence of ALAN, our findings suggest large numbers of NMP species are being exposed to higher ATC concentrations at stopover sites. Outside of migration, large numbers of NMP species that winter along the US Gulf Coast are being exposed for an extended period of time to higher ATC concentrations. Initiatives designed to decrease ALAN during migration have the potential to reduce the acute and chronic effects of ATC contamination, lower the maternal transfer of toxic chemicals to eggs, and decrease the biologically mediated transport of toxic chemicals across regions. However, these initiatives will not benefit species that experience prolonged ATC exposure during the non‐breeding season along the US Gulf Coast, a region that could be a significant source of ATC contamination for North American birds.
Synergism and phenolic bioaccessibility during in vitro co‐digestion of cooked cowpea with orange juice
Authors: Honaiser Tuany Camila , Arcari Stefany Grutzmann , Fabiane Keli Cristina , Rocha Maurisrael de Moura , Fedrigo Isabela Maia Toaldo , Arisi Ana Carolina Maisonnave 
Published: October 2022

SummaryFoods are susceptible to matrix interferences during the gastrointestinal transit that can affect bioactive molecules. We proposed in vitro co‐digestion of cowpea beans and orange juice to assess polyphenols bioaccessibility and synergisms. We performed gastrointestinal simulation combining beans and a fruit beverage, to mimic a common meal in a more realistic set‐up than the usual single‐food models. Twenty phenolic compounds were released in oral, gastric and intestinal compartments and were identified by HPLC‐DAD. Gallic acid, (−)‐epicatechin and chlorogenic acid were the most bioaccessible polyphenols. Cooking and solvent extraction of cowpea beans affected their polyphenolic concentrations. After digestion, the bioaccessibility indexes were higher for cowpea (136.11%) and cooked cowpea (744.74%) when compared to orange juice (31.87%) indicating that the thermal treatment enhanced the bioaccessibility of cowpea phenolics. The antioxidant capacity was higher in the end of co‐digestion compared to cooked cowpea and orange juice digested alone due to synergistic polyphenol‐polyphenol interactions or polyphenol‐protein interactions. The combination of orange juice with cooked cowpea in co‐digestion promoted high content of some bioaccessible phenolics, with 10 out of 20 compounds showing positive interactions at the intestinal phase, suggesting that food synergisms are not neglectable for beans and citrus polyphenols release during the digestion course.
Genomic regions underlying the species‐specific mating songs of green lacewings
Authors: Taylor Katherine L. , Wade Elizabeth J. , Wells Marta M. , Henry Charles S. 
Published: October 2022

AbstractRapid species radiations provide insight into the process of speciation and diversification. The radiation of Chrysoperla carnea‐group lacewings seems to be driven, at least in part, by their species–specific pre‐mating vibrational duets. We associated genetic markers from across the genome with courtship song period in the offspring of a laboratory cross between Chrysoperla plorabunda and Chrysoperla adamsi, two species primarily differentiated by their mating songs. Two genomic regions were strongly associated with the song period phenotype. Large regions of chromosomes one and two were associated with song phenotype, as fewer recombination events occurred on these chromosomes relative to the other autosomes. Candidate genes were identified by functional annotation of proteins from the C. carnea reference genome. The majority of genes that are associated with vibrational courtship signals in other insects were found within QTL for lacewing song phenotype. Together these findings suggest that decreased recombination may be acting to keep together loci important to reproductive isolation between these species. Using wild‐caught individuals from both species, we identified signals of genomic divergence across the genome. We identified several candidate genes both in song‐associated regions and near divergence outliers including nonA, fruitless, paralytic, period, and doublesex. Together these findings bring us one step closer to identifying the genomic basis of a mating song trait critical to the maintenance of species boundaries in green lacewings.
Polyguanine alleviated autoimmune hepatitis through regulation of macrophage receptor with collagenous structure and TLR4‐TRIF‐NF‐κB signalling
Authors: Cai Tingchen , Xu Lanman , Xia Dingchao , Zhu Lujian , Lin Yanhan , Yu Sijie , Zhu Kailu , Wang Xiaodong , Pan Chenwei , Chen Yongping , Chen Dazhi 
Published: October 2022

AbstractAutoimmune hepatitis (AIH) is a progressive and chronic inflammatory disease in the liver. MARCO is a surface receptor of macrophage involving in tissue inflammation and immune disorders. Moreover, polyguanine (PolyG) is considered to bind to macrophage receptor with collagenous structure (MARCO). However, the role of MARCO and PolyG in the development and treatment of AIH still remains unclear. Therefore, this study explores the expression of MARCO and therapeutic activity of PolyG in both S100‐induced AIH in mouse and Lipopolysaccharide (LPS)‐treated macrophage (RAW264.7 cells). Moreover, there were significant increases in inflammatory factors and MARCO, as well as decrease in I‐kappa‐B‐alpha (Ik‐B) in the liver of AIH mice and LPS‐induced cells. However, PolyG treatment significantly reversed the elevation of inflammatory cytokins, MARCO and reduction of Ik‐B. In addition, PolyG treatment could downregulate the expression of Toll‐like receptor 4 (TLR4) and TIR‐domain‐containing adaptor inducing interferon‐β (TRIF), decrease macrophage M1 polarization and increase macrophage M2 polarization. When hepatocytes were co‐cultured with different treatment of macrophages, similar expression profile of inflammatory cytokines was observed in hepatocytes. The research revealed that MARCO expression was elevated in AIH mice. PolyG treatment and inhibition of MARCO significantly reduced inflammatory cytokines expression in the liver as well as hepatocytes and macrophages. Therefore, MARCO could be a target for the treatment of AIH.
SUMOylation facilitates the assembly of a Nuclear Factor‐Y complex to enhance thermotolerance in Arabidopsis
Authors: Huang Junwen , Huang Junjie , Feng Qiyi , Shi Yaqiao , Wang Feige , Zheng Kaiyong , Huang Qize , Jiang Jieming , Luo Siyi , Xie Yun , Han Danlu , Lai Jianbin , Yang Chengwei 
Published: October 2022

ABSTRACTHeat stress (HS) has serious negative effects on plant development and has become a major threat to agriculture. A rapid transcriptional regulatory cascade has evolved in plants in response to HS. Nuclear Factor‐Y (NF‐Y) complexes are critical for this mechanism, but how NF‐Y complexes are regulated remains unclear. In this study, we identified NF‐YC10 (NF‐Y subunit C10), a central regulator of the HS response in Arabidopsis thaliana, as a substrate of SUMOylation, an important post‐translational modification. Biochemical analysis showed that the SUMO ligase SIZ1 (SAP AND MIZ1 DOMAIN‐CONTAINING LIGASE1) interacts with NF‐YC10 and enhances its SUMOylation during HS. The SUMOylation of NF‐YC10 facilitates its interaction with and the nuclear translocation of NF‐YB3, in which the SUMO interaction motif (SIM) is essential for its efficient association with NF‐YC10. Further functional analysis indicated that the SUMOylation of NF‐YC10 and the SIM of NF‐YB3 are critical for HS‐responsive gene expression and plant thermotolerance. These findings uncover a role for the SIZ1‐mediated SUMOylation of NF‐YC10 in NF‐Y complex assembly under HS, providing new insights into the role of a post‐translational modification in regulating transcription during abiotic stress responses in plants.
Ecological model of health behaviour of hypertensive stroke patients at the end of recovery period
Authors: Zhang Li‐Yuan , Wang Meng‐Yao , Deng Cheng‐Song , Lin Man‐Qiu , Chen Jie‐Han , Wan Li‐Hong 
Published: October 2022

AbstractAims and ObjectivesThis study aimed to construct a structural equation model guided by the ecological model to explore the factors influencing health behaviour among hypertensive stroke patients 6 months post‐stroke.BackgroundHealth behaviour is important for recurrence prevention in hypertensive stroke patients. Moreover, previous studies have indicated that health behaviour at the end of the recovery period is of particular concern. The ecological model provides an integrated perspective for explaining the factors influencing health behaviour.DesignA cross‐sectional study guided by the STROBE.MethodsA total of 121 hypertensive stroke patients were included to assess stroke knowledge, health belief, depression, family function, chronic illness resource and health behaviour. A structural equation model was used to explore the health behaviour's factors and pathways.ResultsIn the final ecological model, sex, education level, depression and chronic illness resource directly affected health behaviour. Stroke knowledge directly affected health behaviour and indirectly affected health behaviour through health belief and chronic illness resource. Family function indirectly affected health behaviour through health belief, depression and chronic illness resource. Health belief affected health behaviour indirectly through depression and chronic illness resource.ConclusionsHypertensive stroke patients' health behaviour is jointly and interactively influenced by stroke knowledge, health belief, depression, family function and chronic illness resource. In particular, chronic illness resource is an important mediator of health behaviour.Relevance to Clinical PracticeFor clinical practitioners, health behaviour of men and patients with low educational levels should be specifically focused on. Additionally, it is necessary to provide stroke knowledge, establish health beliefs, control depression emotion and improve family function. Furthermore, chronic illness resources should be improved particularly due to its important mediating role.Patient or Public ContributionParticipants completed demographic and disease‐related questionnaires during hospitalisation and completed other questionnaires when returning to hospital at 6 months follow‐up.
Assisted reproductive technology and neonatal intensive care unit: A retrospective observational study from a single center
Authors: Ibi Kyosuke , Takahashi Naoto 
Published: October 2022

AbstractBackgroundAn increasing number of infants are being conceived using assisted reproductive technology (ART). The effects of infertility treatments (IFTs) on infant outcomes have been extensively debated; however, a consensus has not yet been reached. In the present study, we investigated the impact of IFTs on neonatal intensive care unit (NICU) managements using data collected at a single large NICU center.MethodsWe retrospectively investigated patients admitted to the University of Tokyo Hospital NICU during three different time periods (2010, 2015, and 2020). We included 131, 201, and 323 infants, respectively, and compared a number of factors among groups classified by the mode of conception: spontaneous pregnancy (SP), non‐ART (conceived with assisted ovulation or artificial insemination), and ART. We also compared the mode of conception among inborn singletons.ResultsThe rate of admission of ART infants significantly increased from 2010 (9.1%) to 2015 (22.9%) and 2020 (25.7%) (p values of <0.05 and <0.01, respectively). When compared among inborn singletons, ART infants were more often admitted to NICU (p < 0.01). Congenital anomalies and surgical interventions were significantly more frequent in the SP group than in the ART group (p < 0.01). No significant differences were observed in neonatal outcomes among ART infants from 2010 to 2015/2020.ConclusionsThe rate of ART infants admitted to the NICU has significantly increased, with ART pregnancies now accounting for 25% of admissions to the perinatal medical center. ART procedure may be a risk factor for NICU admission. Neonatal intensive care is becoming increasingly indispensable for ART pregnancies.
Why and when does CFO ranking in top management team informal hierarchy affect entrepreneurial firm initial public offering fraud?
Authors: Zhang Zhe , Gong Mijia , Jia Ming , Zhu Qi 
Published: October 2022

AbstractWe build upon the approach/inhibition theory of power to explain why and when CFO ranking in top management team (TMT) informal hierarchy may be related to entrepreneurial firm initial public offering (IPO) fraud, a typical type of unethical behaviour with potential benefits and costs. Our theory explains why CFOs with high rankings in TMT informal hierarchy tend to have a high level of psychological sense of power and may pay more attention to potential benefits rather than costs of unethical behaviours, resulting in a high likelihood to engage in fraud during IPO process. We further suggest that the positive relationship between CFO ranking in TMT informal hierarchy and entrepreneurial firms IPO fraud is weakened by CEO narcissism (internal environment) and environmental dynamism (external environment), respectively. Based on a sample of Chinese entrepreneurial firms listed in growth enterprise market from 2010 to 2017, we find support for our theoretical predictions. By focusing on the ‘specialist’ executives – CFOs – the findings suggest the need to consider rankings in TMT informal hierarchy when analysing the antecedents of IPO fraud.
Periodontitis and edentulism as risk indicators for mortality: Results from a prospective cohort study with 20 years of follow‐up
Authors: Antonoglou Georgios N. , Romandini Mario , Meurman Jukka H. , Surakka Markku , Janket Sok‐Ja , Sanz Mariano 
Published: October 2022

AbstractAimTo investigate the association between periodontitis and edentulism with cardiovascular disease (CVD) and all‐cause mortality.MethodsBaseline data of 506 subjects including 256 angiographically verified coronary artery disease patients and 250 matched participants in cardiovascular health from the Kuopio Oral Health and Heart study were collected from 1995–1996. Mortality data were accrued until May 31, 2015, and related to baseline periodontal health and edentulism, assessed as exposure and collected by means of clinical and radiographic examination by a single examiner. Cox proportional hazards regression models were fit using covariates such as age, gender, smoking, BMI, and education.The final sample size for the periodontitis models ranged from 358 to 376, while the edentate models included 413 to 503 subjects for CVD and all‐cause mortality, respectively with no missing values in the predictor, confounders, and outcome.ResultsThe strongest association was found between edentulism and CVD and all‐cause mortality (HR: 1.9 CVD, HR: 1.6all‐cause; p < .01).ConclusionsEdentulism considered as a poor oral health marker was associated strongly with CVD mortality while periodontitis was not.
Visual comfort generative design framework based on parametric network in underground space
Authors: Gui Yingbin , Zhou Biao , Xie Xiongyao 
Published: October 2022

AbstractWith the growing demand for a high‐quality life, visual comfort (VC) is becoming increasingly important for improving the quality of underground spaces. The underground space landscape features can be defined by the spatial and material parameters of the components. This study proposes a novel parametric generative network (StepGN) for the 3D generative design of VC. It combines parametric modeling, VC evaluation, and a novel reinforcement learning (RL) model called encoded soft actor critic (ESAC) and simplifies the optimization of complex VC scenes into a parameter‐generating optimization process. Among them, parametric modeling is used to generate a 3D underground space scene with components and material properties through parameterization, and the optimization of parameters depends on the evaluation and RL model. The evaluation model provides reward value, and a new ESAC algorithm is developed. It combines the soft actor‐critic (SAC) algorithm with the encoder process and by setting the reward with a confidence threshold. In addition, the Swin cosine distance (SCD) is used to measure the diversity of the generated scenes. A comparison of the policy types and range conversion methods proves that the stochastic policy and Sigmoid function are more suitable for the generative design of VC. By comparing StepGN with a generative adversarial network‐based generative network (VCGN) and other RL processes, it shows that StepGN can generate discrete distributions of the VC levels and can realize a high‐comfort level scene, and the training speed and stability are considerably improved. Finally, StepGN is applied for the optimization of the Wujiaochang subway station scene in Shanghai, and it is proved that the VC of the generated results can provide a high comfort level.
Bone grafts in dentistry: A case report of migration of bone graft material
Authors: Thwaini Mustafa , Al‐Helou Noor , Lord Tim , McKernon Sarah 
Published: October 2022

AbstractBone graft materials are becoming more frequently utilised in dentistry. The evolution of materials means that practitioners need to understand the wide spectrum of graft materials used both previously and currently. We report a case of a patient who had graft material placed over 35 years ago which presented in a distant site.
What we know and what we don't know about the perioperative use of methadone in children and adolescents
Authors: Boisvert‐Plante Virginie , Poulin‐Harnois Christelle , Ingelmo Pablo , Einhorn Lisa M. 
Published: October 2022

AbstractPostoperative pain control is essential to optimizing patient outcomes, improving satisfaction, and allowing patients to resume their baseline functional activities. Methadone, a synthetic mu‐opioid agonist, has multiple pharmacologic properties that may be optimal for perioperative use. Compared to other opioids, methadone has a longer duration of action, rapid onset, extended dosing intervals, high oral bioavailability, low cost, lack of active metabolites, and action on multiple receptors. The current literature examining the use of methadone in the perioperative care of children and adolescents is limited and most often reported within the context of spine or cardiothoracic surgery. Overall, these studies support the hypothesis that perioperative methadone in pediatric patients may decrease postoperative pain, opioid consumption, length‐of‐stay, and the incidence of some opioid‐related side effects, like constipation and urinary retention. A variety of protocols for the perioperative use of methadone have been described, including a single intraoperative dose as well as multiple small doses within multimodal pain protocols. The superiority of these protocols has not been established. Like all opioids, methadone has a side effect profile which includes nausea, vomiting, reduced GI motility, sedation, and respiratory depression at high doses. There is also a concern that it can cause QTc prolongation in patients. The primary aim of this educational review is to examine the pharmacologic data, published perioperative protocols, dosing considerations, and risks and benefits associated with inclusion of methadone in analgesic regimens for surgical patients. A secondary aim is to introduce opportunities for research around the perioperative use of methadone in children and adolescents. Based on our review, we would prioritize establishing optimal procedure‐specific methadone protocols, determining generalizability for use in routine pediatric surgeries, and investigating methadone safety and efficacy prospectively as the primary opioid for pain management in the postanesthesia care unit or postsurgical floors.
Redundancy allocation under state‐dependent distributional uncertainty of component lifetimes
Authors: Li Jun , Huang Yizhe , Li Yan‐Fu , Wang Shuming 
Published: October 2022

In this paper, we consider a redundancy allocation problem in a series‐parallel system with uncertain component lifetimes of multiple states, which involves multitype components and mixed redundancy strategy. We develop a distributionally robust redundancy allocation model using state‐dependent ambiguity set, which describes the mean, expected cross‐deviation, and the support conditional on each state of the component lifetime distribution. Our structural analysis of the worst‐case system reliability function identifies a concave equivalent for the conditional worst‐case reliability function in each state and achieves an averaged finite piece‐wise affine representation for the overall worst‐case system reliability function, which enjoys valuable operational insights for reliability evaluation and scalable optimization of the redundancy designs. Furthermore, we analyze the reliability guarantees for the worst‐case reliability in optimality under possible misspecification of ambiguity‐set parameters, which admit the structure of “Reliability Target + Target Surplus + Estimated Elasticity,” and insightfully imply that the auxiliary dual variables obtained via solving the design problem can be regarded as the scale of elasticity. Computationally, the redundancy design problem can be linearized and reformulated as a mixed 0–1 second‐order cone program. Exploiting the above finite piece‐wise affine structure of the worst‐case reliability function, the design problem also admits a practical iterative decomposition scheme with finite convergence, which is more scalable especially for the possible situations of large number of states in practice. Finally, numerical experiments including a case with real‐life data of braking system components well justify the value of state information incorporated by our model in producing favorable cost‐effective redundancy designs for reliability operations.