bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Effectiveness of Registered Dietitian Nutritionists in Healthy Behavior Interventions for Managing Type 2 Diabetes in Older Adults: A Systematic Review
Authors: Dobrow Laurel , Estrada Isabella , Burkholder-Cooley Nasira , Miklavcic John 
Published: January 2022

PurposeA systematic review was conducted to assess how the involvement of a registered dietitian nutritionist (RDN) in healthy behavior interventions (HBIs) potentially affects outcomes in older adults with type 2 diabetes (T2D).MethodsLiterature was searched for primary research published between 2016 and 2020 on HBI involving a RDN affecting outcomes in older adults with T2D. Evaluations of hemoglobin A1c (HbA1c), blood glucose, blood pressure, cholesterol, anthropometry, body composition, medication usage, healthcare cost, and self-efficacy and/or adherence to healthy behaviors outcomes were selected for inclusion. All the literature included were summarized, evaluated for certainty of evidence criteria, and assessed for bias.ResultsA total of 12 studies were included for assessment. Involvement of a RDN in HBI was shown to reduce HbA1c, fasting blood glucose, low-density lipoprotein (LDL) cholesterol, and blood pressure and improve lean body mass, body mass index (BMI), and self-efficacy in populations of older adults with T2D. Compared to older adults with T2D receiving HBI involving RDNs, patients receiving usual care may incur higher healthcare costs or longer hospital stays. There was a high certainty of evidence for a RDN involvement in HBI with regard to reduction in HbA1c. There was a moderate certainty of evidence for a RDN involvement in HBI with regard to favorable changes in weight or body composition and cardiometabolic health outcomes. Statistically significant improvements in outcomes were usually sustained in follow-up after conclusion of HBI.ConclusionRDNs may play an integral role in HBIs resulting in improved glycemic control, weight management, cardiovascular outcomes, and presumably comorbidity management. RDNs are important facilitators of diet education and nutrition assessment, which are essential in T2D management and should, therefore, be considered for routine inclusion in interprofessional teams for improved outcomes in older adults with T2D.
The 2018 Japan Floods Increased the Frequency of Yokukansan Prescriptions Among Elderly: A Retrospective Cohort Study
Authors: Ishida Ryoko , Yoshida Shuhei , Kashima Saori , Okazaki Yuji , Matsumoto Masatoshi 
Published: January 2022

ObjectiveThe impact of the 2018 Japan Floods on prescriptions of Yokukansan was evaluated.MethodsThis was a retrospective cohort study based on the National Database of Health Insurance Claims which covers all the prescriptions issued in Japan. Participants were patients aged 65 or older who received any medical care at medical institutions located in the three most-severely affected prefectures between 1 year before and after the disaster. We analyzed the number of new prescriptions of Yokukansan and other Kampo drugs among those who had not been prescribed any Kampo for 1 year before the disaster. Kaplan-Meier analysis and a Cox proportional hazards model were used to evaluate the risk of the disaster for a new prescription.ResultsSubjects comprised 1,372,417 people (including 12,787 victims, 0.93%). The hazard ratio (HR) of the disaster for Yokukansan prescriptions was 1.49 [95% confidence intervals (CI): 1.25–1.78], and 1.54 (95% CI: 1.29–1.84) in the crude and age-sex adjusted model, respectively. The HR of the disaster for prescription of other Kampo drugs in the crude and adjusted model was 1.33 (95% CI: 1.27–1.39), and 1.32 (95% CI: 1.27–1.38), respectively. The magnitude of increase of victims prescribed Yokukansan (31.4%) was statistically higher than for those prescribed other Kampo drugs (19.3%) (p &lt; 0.001).ConclusionThe disaster increased prescriptions of both Yokukansan and other Kampo drugs among elderly victims. The increase was more remarkable in Yokukansan than other Kampo drugs. Clinicians and policymakers should be aware of the increased need for Yokukansan in times of natural disaster.
Allogeneic Stem Cell Transplantation Combined With Transfusion of Mesenchymal Stem Cells in Primary Myelofibrosis: A Multicenter Retrospective Study
Authors: Wang Qingyuan , Xu Na , Wang Yu , Zhang Xi , Liu Limin , Zhou Huifen , Wang Hong , Zhang Xiang , Tang Xiaowen , Fu Chengcheng , Miao Miao , Wu Depei 
Published: January 2022

BackgroundAllogeneic stem cell transplantation (allo-SCT) remains the only effective curative therapy for primary myelofibrosis. Utilization and efficacy of allo-SCT are limited by lethal complications, including engraftment failure, and acute (aGVHD) and chronic graft-versus-host disease (cGVHD). Several clinical trials have explored the use of mesenchymal stem cells (MSCs) in allo-SCT to prevent hematopoietic stem cell (HSC) engraftment failure and control GVHD.MethodsClinical data of 17 patients with primary myelofibrosis who underwent allo-SCT combined with ex vivo expanded MSC transfusion in four centers from February 2011 to December 2018 were retrospectively analyzed.ResultsAll patients received myeloablative conditioning regimen. The median number of transplanted nucleated cells (NCs) per kilogram body weight was 11.18 × 108 (range: 2.63–16.75 × 108), and the median number of CD34+ cells was 4.72 × 106 (range: 1.32–8.4 × 106). MSCs were transfused on the day of transplant or on day 7 after transplant. The median MSC infusion number was 6.5 × 106 (range: 0.011–65 × 106). None of the patients experienced primary or secondary graft failure in the study. The median time to neutrophil engraftment was 13 days (range: 11–22 days), and the median time to platelet engraftment was 21 days (range: 12–184 days). The median follow-up time was 40.3 months (range: 1.8–127.8 months). The estimated relapse-free survival (RFS) at 5 years was 79.1%, and overall survival (OS) at 5 years was 64.7%. Analysis showed that the cumulative incidence of aGVHD grade II to IV was 36% (95% CI: 8%–55%) and that of grade III to IV was 26% (95% CI: 0%–45%) at day 100. The cumulative incidence of overall cGVHD at 2 years for the entire study population was 63% (95% CI: 26%–81%). The cumulative incidence of moderate to severe cGVHD at 2 years was 17% (95% CI: 0%–42%). Seven patients died during the study, with 5 patients succumbing from non‐relapse causes and 2 from disease relapse.ConclusionThe findings of the study indicate that allo-SCT combined with MSC transfusion may represent an effective treatment option for primary myelofibrosis.
An Integrated Pan-Cancer Analysis of 33 Human Cancers Reveals the Potential Clinical Implications and Immunotherapeutic Value of C-X-C Motif Chemokine Ligand 13
Authors: Zhang Huanyu , Yin Honghao , Chen Jing , Yuan Yuan 
Published: January 2022

BackgroundC-X-C Motif Chemokine Ligand 13 (CXCL13) plays a crucial part in the pathogenesis of numerous lymphoproliferative disorders, inflammatory responses, and autoimmune diseases. CXCL13 also influence tumor development and prognosis, and be a potential target for cancer treatment. However, CXCL13 expression-based panoramic picture in pan-cancer remain unclear. This study focused on elucidating different expression levels, prognostic significance, immune-related characteristics, epigenetic variations, and immunotherapeutic value of CXCL13.MethodsBased on different databases such as TCGA, GTEX, CCLE and HPA, we studied the expression of CXCL13 in different tissues at different levels. Moreover, we analyzed the correlation between CXCL13 expression and clinicopathological characteristics, prognosis, Mismatch Repair Genes (MMRs), Microsatellite Instability (MSI), tumor mutation burden (TMB), immune cells infiltration, immune-related genes, and the role in tumor immunotherapy. And the expression of CXCL13 in digestive tract cancers and the correlation between CXCL13 and immune genes were further analyzed by histological verification.ResultsCXCL13 was highly expressed in various tumor tissues and was also closely related to prognosis. CXCL13 expression levels were closely related to MSI, TMB and immune cells infiltration, including CD8+ T cells, macrophages, follicular helper T cells and B cells. CXCL13 expression levels were related to immune checkpoint genes and the efficacy of immunotherapy.ConclusionCXCL13 might be a useful biomarker for determining the diagnosis and prognosis of human cancers but also a biomarker for evaluating the efficacy of immunotherapy.
LncRNA SNHG1 Promotes the Progression of Pancreatic Cancer by Regulating FGFR1 Expression via Competitively Binding to miR-497
Authors: Chen Shihong , Guo Wenyi , Meng Mingyang , Wu Dong , Zhou Tao , Wang Lei , Xu Jianwei 
Published: January 2022

BackgroundLong noncoding RNA small nucleolar RNA host gene 1 (SNHG1) is dysregulated in a variety of tumors. However, little is known of its role in pancreatic cancer (PC).MethodsThe role of SNHG1 on PC cell proliferation, migration, invasion, apoptosis, and the epithelial-mesenchymal transition (EMT) were assessed in vitro using MTT, EDU, wound healing, and Transwell assays, as well as flow cytometry and western blotting. Luciferase reporter assay, western blotting, and qRT-PCR were used to examine SNHG1 regulation. Tumor growth in mice was also investigated.ResultsDownregulation of SNHG1 blocked cell proliferation, migration and invasion, and induced apoptosis in vitro, while also inhibiting the EMT, shown by changes in the biomarkers E-cadherin, N-cadherin, and Vimentin. The opposite results were observed on upregulation of SNHG1. In vivo experiments showed that downregulation of SNHG1 inhibited tumor development in nude mice. Furthermore, experiments investigating the regulatory mechanism of SNHG1 indicated that SNHG1 acted as a competitive endogenous RNA, positively regulating the expression of fibroblast growth factor receptor 1 (FGFR1) through sponging miR-497. Rescue experiments demonstrated that the effects of SNHG1 downregulation on PC cells were attenuated when simultaneously inhibiting the levels of miR-497.ConclusionsSNHG1 upregulates FGFR1 expression by sponging miR-497, which promotes the progression of PC. SNHG1 may thus be a novel target for treating PC.
Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis
Authors: Zhang Yang , Huang Lei , Zhang Jinmei , De Souza Rastelli Alessandra Nara , Yang Jingmei , Deng Dongmei 
Published: January 2022

Objective: Curcumin has been used as an adjunct to non-surgical periodontal treatment. However, the efficacy of curcumin in the periodontal therapy remained controversial. This study aimed to evaluate the anti-inflammatory efficacy of curcumin as an adjunct to non-surgical periodontal treatment (NPT) by systematic review.Methods: Databases including Embase, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov were searched to identify relevant RCTs on the use of curcumin as an adjunct to NPT for the treatment of periodontal disease from inception to July 21, 2021. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was then performed using Review Manager 5.3 software.Results: A total of 18 RCTs involving 846 patients/sites were included in this meta-analysis. The results of the meta-analysis revealed that as compared to NPT alone, curcumin as an adjunct to NPT resulted in significant reduction in gingival index (GI) at the 1-week (mean differences (MD) = −0.15, 95% confidence intervals (CI) −0.26 to −0.05, p = 0.005), 2-week (MD = −0.51, 95%CI −0.74 to −0.28, p &lt; 0.0001), 3-week (MD = −0.34, 95%CI −0.66 to −0.02, p = 0.03), 4-week (MD = −0.25, 95%CI −0.48 to −0.02, p = 0.04) or 6-week (MD = −0.33, 95%CI −0.58 to −0.08, p = 0.01) follow-ups. Similar significant reductions were also observed for sulcus bleeding index (SBI) at 1, 2, 4, and 12 weeks. However, there were no statistically significant differences in reducing bleeding on probing (BOP) between curcumin as an adjunct and NPT alone at 4, 12, and 24 weeks.Conclusion: Based on the current evidence, curcumin demonstrates anti-inflammatory efficacies in terms of reducing GI and SBI compared with NPT alone. Moreover, curcumin is a natural herbal medicine with few side effects, and it is a good candidate as an adjunct treatment for periodontal disease.
Early Clinical Effects of Novel Partial D3/D2 Agonist Cariprazine in Schizophrenia Patients With Predominantly Negative Symptoms (Open-Label, Non-controlled Study)
Authors: Ivanov Stanislav V. , Smulevich Anatoly B. , Voronova Evgeniya I. , Yakhin Kausar K. , Beybalaeva Tangyul Z. , Katok Alena A. 
Published: January 2022

BackgroundBecause of limited efficacy of antipsychotics against negative symptoms in schizophrenia new drugs with wider spectrums of clinical efficacy are very desirable. The newer 3rd generation antipsychotic cariprazine presents the unique mode of action acting as partial agonist predominantly for dopamine D3- and in lesser extent D2-receptors. Cariprazine is found to be effective in the treatment of negative symptoms in schizophrenia comparing to second generation antipsychotic risperidone.ObjectivesTo evaluate initial effects of cariprazine in schizophrenia patients with predominantly negative symptoms.Design and PatientsOpen-label, non-controlled study included 60 adult schizophrenia patients (F20 on ICD-10, 49% males) with predominantly negative symptoms (Positive and Negative Syndrome Scale, S factor score for negative and positive symptoms, PANSS-FSNS ≥ 15 and PANSS-FSPS &lt;19) treated with cariprazine (starting daily dose 1.5 mg followed by upward titration by 1.5 mg weekly up to 6 mg if needed) were assessed with PANSS, CAINS (The Clinical Assessment Interview for Negative Symptoms), CDSS (Calgary Depression Scale for Schizophrenia), and SAS (Simpson-Angus Scale for Extrapyramidal Symptoms) scales at baseline and on week 1, 2, and 4.ResultsMost patients (75%) improved during 28 days of cariprazine treatment. At the end of assessment (day 28) mean starting total scores for negative symptoms on PANSS-NS and CAINS scales significantly (p &lt; 0.05) reduced by 4.3 and 4.9, respectively, with no significant changes in depression symptoms (CDSS). Cariprazine tolerability was very good, only four patients discontinued because of TEAEs (akathisia, insomnia).ConclusionsThe results of this study suggest early effect of cariprazine on negative symptoms at least in some schizophrenia patients with predominantly negative symptoms starting from 1 to 2 weeks of treatment and could be useful for determination of early clinical predictors for efficacy. Considering limitations of open-label design with no control groups these data need to be confirmed.
Utilization of a Mobile Multifunctional Workstation for Coronavirus Nasopharyngeal/Oropharyngeal Specimen Collection
Authors: Lian Xiaojing , Zhang Lili , Zhao Yang , Li Yuhua , Jing Xuemin , Liu Xin , Han Jianing , Ma Jianhong , Zhang Yongyong , Guo Huimin , Huang Xiaojie 
Published: January 2022

ObjectivesThis study aimed to explore the utilization of a mobile multifunctional workstation for COVID-19 sample collection.MethodsTwenty-four nurses and 150 individuals who took nucleic acid tests using mobile multifunctional workstations in Beijing Youan Hospital, Capital Medical University, from September to November 2020, were enrolled in the study as the observation group. As the control group, we included 36 nurses and 150 individuals who did not use the workstations from June to September 2020. We compared the two groups on (1) comfort of working environment, self-perceived security, the convenience of information system, operational process flexibility, pharyngeal acquisition visibility, and effectiveness of communication among nurses; and (2) self-perceived safety, waiting time, and overall satisfaction among individuals who took nucleic acid tests.ResultsThe satisfaction score of nurses in the observation group of nurses were significantly higher than those of the control group (OR = 17.297 95% CI:4.294, 69.673), as well as the convenience of the information system (OR = 6.250 95% CI: 1.775, 22.008), and communication effectiveness (OR = 5.588 95% CI: 1.590, 19.646). Among individuals who took nucleic acid tests, the overall satisfaction (P &lt; 0.05) and self-perceived security (P &lt; 0.05) had statistical differences between the observation group and the control group.ConclusionsThe mobile multifunctional workstation for specimen collection could improve the comfort of the working environment, the convenience of information systems, and the effectiveness of communication among nurses.It can improve satisfaction and self-perceived security among people who took nucleic acid tests.
A Modeling and Neutron Diffraction Study of the High Temperature Properties of Sub-Stoichiometric Yttrium Hydride for Novel Moderator Applications
Authors: Mehta Vedant K. , Vogel Sven C. , Kotlyar Dan , Cooper Michael W. D. 
Published: January 2022

Low-enriched-uranium (LEU) reactor systems utilize moderators to improve neutron economy. Solid yttrium hydride is one of the primary moderator candidates for high-temperature (>700 °C) nuclear reactor applications. This is due to its ability to retain hydrogen at elevated temperatures compared to other metal hydrides. For reactor modeling purposes, both neutronic and thermos-mechanical modeling, several high-temperature properties for sub-stoichiometric yttrium hydride (YH2−x) are needed. In this paper, we present an atomistics and a neutron diffraction study of the high-temperature properties of Y and YH2−x. Specifically, we focus on the thermal lattice expansion effects in yttrium metal and yttrium hydride, which also govern bulk thermal expansion. Previously reported physical and mechanical properties for sub-stoichiometric yttrium hydride at ambient conditions are expanded using lattice dynamics to take into account high-temperature effects. Accordingly, an array of newly generated properties is presented that enables high-fidelity neutronics, and thermomechanical modeling. These properties include various elastic moduli, thermal expansion parameters for yttrium and yttrium hydride, and single-phase (YH2−x) and two-phase (Y + YH2−x) density as a function of stoichiometry and density.
Anxiety problems in children and adolescents: a population-based cohort study on incidence and management in Dutch primary care
Authors: Koet Lukas BM , de Schepper Evelien IT , Bohnen Arthur M , Bindels Patrick JE , Gerger Heike 
Published: January 2022

BackgroundDue to a large strain on youth mental health care, general practice is suggested as an alternative treatment setting for children and adolescents with anxiety problems. However, research on the current management of these children and adolescents within general practice is scarce.AimTo investigate the incidence of coded anxiety in general practice using the International Classification of Primary Care (ICPC), and GPs’ management of children and adolescents presenting with anxiety problems.Design and settingPopulation-based cohort study using electronic medical records of 51 212 children (aged 0–17 years) in primary care in the Rotterdam region between 1 January 2012 and 31 December 2018.MethodIncidence of ICPC codes for anxiety were calculated, then the characteristics of children and adolescents consulting their GP with anxiety and the GPs’ management were assessed qualitatively using quantitative content analysis.ResultsIncidence of ICPC codes for anxiety in children and adolescents was 5.36 (95% confidence interval [CI] = 5.02 to 5.71) per 1000 person–years. Adolescent females had the highest incidence with 14.01 (95% CI = 12.55 to 15.58) per 1000 person–years. Of the 381 children and adolescents consulting their GP with an initial anxiety problem (median age 13.3 years, 40.4% male), GPs referred 59.3% to mental health care in the first year while 26.5% of children and adolescents were managed by a specialised practice nurse within general practice. Of the 381 children and adolescents, 10.5% received psychiatric medication during the first year, with the trend being for increased prescriptions during adolescence.ConclusionIn general practice children and adolescents frequently received one of two ICPC codes for anxiety, especially adolescent females. Most presenting to their GP with anxiety problems are referred externally or seen by a specialised practice nurse within general practice.
PERAN BK DALAM IDENTIFIKASI KEBUTUHAN DAN MASALAH SISWA (IKMS) UNTUK MENINGKATKAN HASIL BELAJAR
Authors: Hadicahyono Wachid 
Published: January 2022

Identifikasi kebutuhan dan masalah siswa merupakan salah satu instrumen yang digunakan dalam penelitian ini. Maksud dan tujuan dilakukan penelitian ini merupakan respon dari menurunnya motivasi belajar siswa di SMAN 1 Pagaden. Penulis sebagai guru BK berkolaborasi dengan wali kelas dan guru mata pelajaran untuk menemukan sebuah formulasi yang dapat meningkatkan kembali motivasi belajar siswa. Lebih lanjut penelitian ini, sebagai upaya meningkatkan hasil belajar siswa di Kelas X IPS 2 yang berdasarkan statistik diantara kelas X IPS yang lainnya rata-rata dalam pelajaran siswanya mengalami kesulitan dalam belajar. Hal ini dapat dilihat dari capaian nilai siswa yang banyak mendapatkan nilai di bawah KKM (Kriteri Ketuntasan Minimum). Berdasarkan hasil analisa dari identifikasi kebutuhan dan masalah siswa (IKMS) didapati bahwa kurangnya motivasi belajar siswa di Kelas X IPS 2 yang disebabkan mengalami kejenuhan dengan gaya mengajar guru yang monoton. Temuan ini menjadi rekomendasi kepada walikelas Kelas X IPS 2 dan guru mata pelajaran untuk mengubah gaya mengajar. Situasi yang berbeda pada proses pembelajaran ternyata memberikan hasil belajar yang sangat sigifikan dari angka sekitar 57% naik menjadi 84%. Penelitan ini diharapkan menjadi sebuah model kerja sama antar guru mata pelajaran agar menghasilkan pembelajaran yang terpadu
KEPUASAN PERKAWINAN DITINJAU DARI RELIGIUSITAS PADA PASANGAN INFERTIL DI KELURAHAN SEI SIKAMBING D
Authors: Wibiren Winnie 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui hubungan antara religiusitas dengan kepuasan perkawinan. Hipotesis yang diajukan dalam penelitian ini adalah ada hubungan positif antara religiusitas dengan kepuasan perkiawinan, dengan asumsi semakin tinggi religiusitas maka semakin tinggi kepuasan perkawinan dan sebaliknya semakin rendah religiusitas maka semakin rendah kepuasan perkawinan.Subjek penelitian yang digunakan dalam penelitian ini adalah pasangan suami istri yang belum dikaruniai anak setelah menikah selama 2 tahun, di Kelurahan Sei Sikambing D, yang berjumlah 80 orang / 40 pasangan. Penelitian ini menggunakan metode Purposive Random Sampling. Data diperoleh dari skala untuk mengukur religiusitas dan kepuasan perkawinan.Perhitungan dilakukan dengan melalui uji prasyarat analisis (uji asumsi) yang terdiri dari uji normalitas sebaran dan uji linearitas hubungan. Analisis data yang digunakan adalah menggunakan korelasi Pearson melalui bantuan SPSS 17 for Windows. Hasil analisis data menunjukkan koefisien korelasi sebesar 0,610 dengan p sebesar 0,000 (p < 0,05). Ini menunjukkan ada hubungan positif antara empati dengan perilaku prososial. Religiusitas merupakan salah satu faktor yang mempengaruhi perilaku prososial dengan sumbangan (R2) sebesar 37.2% selebihnya 66.8% dipengaruhi oleh faktor lain yang tidak diteliti. Dari hasil penelitian ini dapat ditarik kesimpulan bahwa hipotesis penelitian ada hubungan positif antara religiusitas dan kepuasan perkawinan, dapat diterima.