bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Eleutherococcus senticosus Cortex on Recovery from the Forced Swimming Test and Fatty Acid β-Oxidation in the Liver and Skeletal Muscle of mice
Authors: Maho Sumiyoshi  , Yoshiyuki Kimura  
Published: June 2022

Objective:
The root and stem barks of Eleutherococcus senticosus have been used to treat emotional and physical fatigue in China, Russia, Korea, and Japan. The effects of E. senticosus on recovery from physical fatigue and the expenditure of energy currently remain unclear. We herein examined the effects of E. senticosus extract on recovery from physical fatigue after the forced swimming test as well as fatty acid β-oxidation in the liver and skeletal muscle of mice.

Methods:
1) Physical fatigue; E. senticosus extract (500 and 1000 mg/kg, twice daily) was administered orally to ICR male mice for 7 consecutive days. After swimming had been performed for 15 min, each mouse was placed on the cover of a 100-mm culture plate, and the time for each mouse to move away from the cover was measured. 2) Fatty acid β-oxidation in the liver and skeletal muscle; E. senticosus extract (500 and 1000 mg/kg) was administered orally twice daily to C57BL/6J male mice for 21 consecutive days. The initial and final body and liver weight were measured, and then fatty acid β-oxidation activity in the liver and skeletal muscle was measured by methods using [1-14C] palmitic acid.

Key Findings:
Recovery times after forced swimming were shorter in E. senticosus extract (500 and 1000 mg/kg)-treated mice than in vehicle-treated mice. The body and liver weight had no effect by the oral administration of E. senticosus extract, vitamin mixture and L-carnitine. Fatty acid β-oxidation activity in skeletal muscle was increased by E. senticosus extract (500 and 1000 mg/kg).

Conclusion:
E. senticosus may enhance recovery from physical fatigue induced by forced swimming by accelerating energy changes through fatty acid β-oxidation in skeletal muscle.
Natural Macromolecules in the Development of Safe and Effective Gastroretentive Floating Microparticles of Metformin Hydrochloride
Authors: Mukesh Pandey  , Madhuri Maher  , Mona Semalty  , Ajay Semalty  
Published: June 2022

Background:
Metformin hydrochloride, an oral hypoglycaemic, shows better absorption from upper part of the gastric region. Natural/herbal substances have been investigated for the development of natural polymer-based drug delivery systems owing to the desirable properties like biodegradability, biocompatibility, aqueous solubility, swelling ability, easy availability and cost effectiveness.

Method:

Therefore, three natural macromolecules: Glycine max (soya chunks), Metroxylon sagu (sago starch) and Plantago ovata (psyllium husk) were used for developing its gastroretentive floating microparticles for expected improvement in bioavailability. The macromolecules and the prepared microparticles were evaluated for physicochemical properties, FTIR, XRPD, DSC and dug release.

Result:

The percent drug content was in the range of 60.353 ± 1.25 to 92.682 ± 2.47 % for all the microparticles. All the formulations showed good swelling and floating properties (the formulation prepared with P. ovata showed the best swelling and in vitro floatability). The FTIR studies showed that the herbal carriers were compatible with the drug. XRD and DSC studies showed a transition in the physical state of the drug in the formulations from crystalline state to amorphous state. In vitro drug release studies showed good percent cumulative drug release from all the formulations (72.13 to 87.06 % at the end of 6 hour) with non-fickian diffusion process.

Conclusion:

Therefore, it was concluded that the herbal macromolecules may be the potential, safe and effective carriers for improving the drug delivery of the metformin like drugs by developing, effective gastroretentive floating drug delivery systems.
Product Life Cycle Management for Pharmaceutical Innovation
Authors: Tripathy Swagat , Prajapati Vandana , Guruswamy VijayaKumar Sengodan 
Published: June 2022

Background:
Continuous innovation is the unique feature of a pharmaceutical industry and is also prerequisite for sustainment of this industry. However, the dipping number of new molecules, rising costs of drug development, heightened health authority scrutiny and increased competition from generic industry indicate that the innovation is endangered.

Methodology:
The methodology used is a comparative study on the basis of original empirical research. More specifically, the part of examination facts and regulation has been written by conducting empirical research on current international and national resources concerning the subject from books, various Guidelines, Rules and regulations, Articles, Published Reports and internets.

Results:
The importance of innovation has been fairly realized by the industry and regulatory authorities as evident from the rise in number of new molecules approved by US FDA in 2014. To safeguard innovation, Product Lifecycle Management (PLM) should be incorporated in the business models of a pharmaceutical company. It not only helps to maximize lifecycle of the product but also to improve the product development processes, make better business decisions and to deliver greater value to consumers.

Conclusion
A pharmaceutical product’s life is always complex & unique in nature and can be described in five distinct phases- development phase, approval phase, introduction phase, commercialization & quality management phase and decline phase. Number of strategies to be applied at each stage and the strategies are generally coupled with regulations, and the choice of strategy may vary on country to country. In present manuscript, the scope of various PLM strategies for innovators in four different countries namely, USA, EU, Canada and India has been discussed. This may guide the innovators to have competency to uphold the basic necessity for their survival, i.e. innovation.
FREQUENCY OF CHRONIC DIABETES COMPLICATIONS IN CHILDREN AND ADOLESCENTS IN THE SOUTHERN REGION OF UKRAINE ACCORDING TO THE DATA OF THE REGISTER
Authors: Globa E. V. 
Published: June 2022

We investigated frequency of chronic complications, their dependence on the diabetes mellitus duration and the age of children who reside in the southern region of Ukraine according to on the data of the register of children patients with diabetes mellitus. Chronic complications are more frequent when combined with neuropathy, retinopathy, hairopathy. The frequency of chronic complications has a dependence upon diabetes mellitus duration and increase in the HbA1c level. The level HbA1c is higher in more grown children with longer duration of the disease.
THE NEAREST AND REMOTE CONSEQUENCES OF ESTROGENIZATION FOR RATS SPERMATOGENESIS
Authors: Gladkova A. I. , Sidorova I. V. 
Published: June 2022

The estradiol application to male rats leads to suppression of the testis incretory and generative function, showing by decreases of testosterone concentration in blood, negative changes of quantitative and quality indexes of spermatogenesis. Spermatogones are more sensitive to negative action of estrogenization in comparison with cells of serotinal stages of spermatogenesis. Returning to norm of spermogram indexes in a new cycle of a spermatogenesis specifies in convertibility of estrogenization negative consequences
PECULIARITIES OF FOLLICULAR EPITHELIUM PROLIFERATION IN ADENOMAS OF THE THYROID GLAND
Authors: Khaziev Vadym , Goydenko N. I. , Gorgul N. G. 
Published: June 2022

Among adenomas of the thyroid gland, microfollicular adenomas predominate
structures (47.67%). The study of the processes of hyperplasia of the follicular epithelium in adenomas of different types of structure showed that the proliferation of the follicular epithelium
it develops most intensively in microfollicular and solid adenomas with an increase in proliferates of structural and cellular atypia. Definition of optical
DNA density revealed a significantly higher level in microfollicular and solid adenomas in comparison with other forms of adenomas. Appearance of papillary structures
as a variant of hyperplasia indicates that hyperplasia may occur without symptoms maturation and formation of typical structures of thyroid tissue
TOXICOLOGIST'S VIEW ON ANTUCOTHERAL DRUG WITH ANTIESTROGEN ACTION TAMOXIFEN
Authors: Melnykivska N. V. , Kudrya M. Ya. , Kozar V. V. , Ustenko N. V. , Kudrya O. V. , Zhurakovskaya M. V. , Pavlenko T. O. 
Published: June 2022

An analysis of the literature on the toxic properties of tamoxifen, which. characterized by high carcinogenic potential, embryo- and hepatotoxicity, adverse effects on the reproductive system of experimental animals
both articles. The results of our own experimental studies show that that features of toxic action of drug in the conditions of epicutaneous and inhalation
exposures include immunosuppression, rat liver dysfunction and the development of endogenous intoxication due to the accumulation of medium molecular weight peptides and
products of lipid peroxidation
INVESTIGATION OF MICROSTRUCTURE OF INTERNAL ORGANS OF EXPERIMENTAL ANIMALS AFTER FENCUCINAL OINTMENT APPLICATIONS
Authors: Sergienko L. Yu. , Kustova Svitlana , Kudrya M. Ya. , Kartavtseva O. V. , Cherevko G. M. , Boyko Maryna , Tolmachova L. M. , Zhurakovskaya M. V. , Pavlenko T. O. 
Published: June 2022

Histological examinations of the microstructure of the internal organs of experimental animals were performed, which received ointment dermally for one month.
fensuccinal at a dose of 2500 mg / kg body weight. Under these experimental conditions, no damaging effect of fensuccinal ointment on the organs of experimental animals was detected.
CLINIC AND TREATMENT OF SILV-LOSING SYNDROME IN CONGENITAL DYSFUNCTION OF THE ADRENAL CORE
Authors: Bolshova O. V. 
Published: June 2022

Congenital dysfunction of the adrenal cortex (adreno-genital syndrom, congenital hyperplasia of the adrenal cortex) - a group of heterogeneous hereditary diseases, which are based on the primary violation of steroidogenesis in the cortical substance of the adrenal glands, which leads
to various metabolic disorders and is manifested by clinical manifestations of changes in the rate and nature of puberty and growth disorders.
Long-Term Postoperative Pain Prediction Using Higher-Order Singular Value Decomposition of Intraoperative Physiological Responses: Prospective Cohort Study
Authors: Baharloo Raheleh , Principe Jose , Rashidi Parisa , Tighe Patrick 
Published: June 2022

Background
Long-term postoperative pain (POP) and patient responses to pain relief medications are not yet fully understood. Although recent studies have developed an index for the nociception level of patients under general anesthesia based on multiple physiological parameters, it remains unclear whether these parameters correlate with long-term POP outcomes.

Objective
This study aims to extract unbiased and interpretable descriptions of how the dynamics of physiological parameters change over time and across patients in response to surgical procedures and intraoperative medications using a multivariate-temporal analysis. We demonstrated that there is an association (correlation) between the main features of intraoperative physiological responses and long-term POP, which has a predictive value, even without claiming causality.

Methods
We proposed a complex higher-order singular value decomposition method to accurately decompose patients’ physiological responses into multivariate structures evolving over time. We used intraoperative vital signs of 175 patients from a mixed surgical cohort to extract three interconnected, low-dimensional, complex-valued descriptions of patients’ physiological responses: multivariate factors, reflecting subphysiological parameters; temporal factors, reflecting common intrasurgery temporal dynamics; and patients’ factors, describing interpatient changes in physiological responses.

Results
Adoption of the complex higher-order singular value decomposition method allowed us to clarify the dynamic correlation structure included in the intraoperative physiological responses. Instantaneous phases of the complex-valued physiological responses of 242 patients within the subspace of principal descriptors enabled us to discriminate between mild and not-mild (moderate-severe) levels of pain at postoperative days 30 and 90. Following rotation of physiological responses before projection to align with the common multivariate-temporal dynamic, the method achieved an area under curve for postoperative day 30 and 90 outcomes of 0.81 and 0.89 for thoracic surgery, 0.87 and 0.83 for orthopedic surgery, 0.87 and 0.88 for urological surgery, 0.86 and 1 for colorectal surgery, 1 and 1 for transplant surgery, and 0.83 and 0.92 for pancreatic surgery, respectively.

Conclusions
By categorizing patients into different surgical groups, we identified significant surgery-related principal descriptors. Each of them potentially encodes different surgical stimulation. The dynamics of patients’ physiological responses to these surgical events were linked to long-term POP development.
Telehealth and Intimate Partner Violence: A Systematic Review of Telehealth Interventions
Authors: Chan Georgia Yin Chun , Cruz-Sánchez Margarita , Bhuptani Prachi H , Millman Christopher , Orchowski Lindsay M 
Published: June 2022

Background
Intimate partner violence (IPV) is a global public health problem and often leads to deleterious outcomes. IPV is associated with elevated psychological distress, impaired physical health, and high rates of morbidity and mortality. Since the start of the COVID-19 pandemic in December 2019, there has been an exponential increase in the rates of IPV worldwide. The COVID-19 pandemic has also heralded an increased use of telehealth to deliver medical and psychological services. Telehealth is defined as the use of technology communication systems (ie, mobile apps, videoconferencing, etc) in the provision of health care. Given increases in access to Wi-Fi and computing technology, telehealth has become increasingly popular in all types of health care interventions, including those for IPV.

Objective
Reviewing and synthesizing information on telehealth intervention, screening, and prevention for IPV is essential for our knowledge of the efficacy and future of telehealth in IPV. Accordingly, this study conducted a systematic review of telehealth interventions for IPV, with a focus on screening and intervention for IPV victimization and perpetration.

Methods
This study applied the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to a literature search that identified research evaluating telehealth and telemedicine interventions for DV and IPV. Only 14 studies met the study inclusion criteria, with 3 articles focusing on telehealth screening for IPV and 11 articles studying telehealth interventions for IPV.

Results
The studies demonstrated heterogeneity in the (1) purpose of the intervention (screening, prevention, or treatment), (2) type of intervention delivered via telehealth (website vs telephone vs videoconferencing) and intervention dosage, and (3) outcomes assessed. Scientific rigor according to the Oxford Center for Evidence-Based Medicine was also variable. Studies predominantly focused on women. The results show promising evidence of the efficacy of telehealth screening (over face-to-face screening) for IPV victimization. Only specific types of telehealth interventions were shown to have promise for reducing psychological distress among IPV survivors. The results suggest that telehealth may be a viable option for the delivery of IPV screening and intervention programs, especially when face-to-face interaction is not feasible.

Conclusions
The present findings highlight the growing utilization of telehealth modalities for IPV screening and intervention. Further research is needed to enhance the evidence base for the telehealth screening, prevention, and intervention of IPV and to evaluate the effectiveness of the approaches for individuals involved in IPV.

Conflicts of Interest
None declared.
Telehealth and Intimate Partner Violence: A Systematic Review of Telehealth Interventions (Preprint)
Authors: Chan Georgia Yin Chun , Cruz-Sánchez Margarita , Bhuptani Prachi H. , Millman Christopher , Orchowski Lindsay M. 
Published: June 2022

BACKGROUND

Intimate partner violence (IPV) is a global public health problem and often leads to deleterious outcomes. IPV is associated with elevated psychological distress, impaired physical health, and high rates of morbidity and mortality. Since the start of the COVID-19 pandemic in December 2019, there has been an exponential increase in the rates of IPV worldwide. The COVID-19 pandemic has also heralded an increased use of telehealth to deliver medical and psychological services. <i>Telehealth</i> is defined as the use of technology communication systems (ie, mobile apps, videoconferencing, etc) in the provision of health care. Given increases in access to Wi-Fi and computing technology, telehealth has become increasingly popular in all types of health care interventions, including those for IPV.

OBJECTIVE

Reviewing and synthesizing information on telehealth intervention, screening, and prevention for IPV is essential for our knowledge of the efficacy and future of telehealth in IPV. Accordingly, this study conducted a systematic review of telehealth interventions for IPV, with a focus on screening and intervention for IPV victimization and perpetration.

METHODS

This study applied the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to a literature search that identified research evaluating telehealth and telemedicine interventions for DV and IPV. Only 14 studies met the study inclusion criteria, with 3 articles focusing on telehealth screening for IPV and 11 articles studying telehealth interventions for IPV.

RESULTS

The studies demonstrated heterogeneity in the (1) purpose of the intervention (screening, prevention, or treatment), (2) type of intervention delivered via telehealth (website vs telephone vs videoconferencing) and intervention dosage, and (3) outcomes assessed. Scientific rigor according to the Oxford Center for Evidence-Based Medicine was also variable. Studies predominantly focused on women. The results show promising evidence of the efficacy of telehealth screening (over face-to-face screening) for IPV victimization. Only specific types of telehealth interventions were shown to have promise for reducing psychological distress among IPV survivors. The results suggest that telehealth may be a viable option for the delivery of IPV screening and intervention programs, especially when face-to-face interaction is not feasible.

CONCLUSIONS

The present findings highlight the growing utilization of telehealth modalities for IPV screening and intervention. Further research is needed to enhance the evidence base for the telehealth screening, prevention, and intervention of IPV and to evaluate the effectiveness of the approaches for individuals involved in IPV.
Taubat Pelaku Pembunuhan Sengaja dalam Al-Qur’an
Authors: Simangunsong Ali Abdurahman , Zaini Muhammad , Fadhli Muhajirul 
Published: June 2022

Taubat is one of the religious commandments that man must do. In the Koran, there are many verses that command to repent. On the other hand, the act of killing deliberately is regarded by some mufasir as an act that which there is no repentance (taubat) for the perpetrator. This study wants to see what verses in the Koran are indicated to have a connection with taubat for perpetrators of intentional murder and its interpretation and how the mufasir views related to taubat for perpetrators of intentional murder. This research is a library study and the data is presented using thematic methods. The mufasir referred to in this study are Ibn Katsīr, Hamka, M. Quraish Shihab, al-Qurthubi and Wahbah al-Zuhaili. The results showed that some scholars from salāf circles argued that it was not accepted by people who had committed intentional killings. Meanwhile, the scholars of both salāf and khalāf hold the view that people who have committed the act of killing intentionally still have the opportunity to repent to Allah. Then in an effort to repent, the mufasir took the view that whoever repents of the deeds of wrongdoings earnestly and cheerfully and works righteous charity, then Allah will abolish His torment and bestow upon him a reward. Taubat merupakan salah satu dari perintah agama yang harus dilakukan manusia. Di dalam Alquran, terdapat banyak ayat yang memerintahkan untuk bertaubat. Di sisi lain, perbuatan membunuh dengan sengaja dianggap oleh sebagian mufasir sebagai perbuatan yang tidak ada taubat bagi pelakunya. Kajian ini ingin melihat ayat-ayat apa saja di dalam Alquran yang terindikasi memiliki kaitan dengan taubat bagi pelaku pembunuhan sengaja dan penafsirannya serta bagaimana pandangan mufasir terkait taubat bagi pelaku pembunuhan sengaja. Penelitian ini bersifat kajian perpustakaan dan data yang disajikan dengan menggunakan metode tematik. Para mufasir yang menjadi rujukan dalam kajian ini adalah Ibnu Katsīr, Hamka, M. Quraish Shihab, al-Qurthubi dan Wahbah al-Zuhaili. Hasil penelitian menunjukkan bahwa sebagian ulama dari kalangan salāf berpendapat bahwa tidak diterima taubat dari orang yang telah melakukan pembunuhan dengan sengaja. Sementara itu, jumhur ulama dari salāf maupun khalāf memiliki pandangan bahwa orang yang telah melakukan perbuatan membunuh dengan sengaja masih memiliki kesempatan untuk bertaubat kepada Allah. Kemudian dalam upaya untuk bertaubat, jumhur para mufasir berpandangan bahwa barangsiapa yang bertaubat dari perbuatan maksiat dengan sungguh-sungguh dan penuh keridhaan, serta mengerjakan amal saleh, maka Allah akan menghapuskan siksa-Nya dan menganugerahkan kepadanya pahala.
Consideraciones relacionadas con los inductores de la innovación: Observaciones teóricas y empíricas
Authors: Alfaro-Ramos Alfredo Elías , Silva-Atencio Gabriel 
Published: June 2022

El objetivo es revisar sistemáticamente la literatura empírica sobre gestión del conocimiento, capital intelectual e innovación en busca de vacíos que posibiliten futuras líneas de investigación. La investigación metodológica se orientó a la revisión documental, bajo un enfoque cualitativo. Se encuentran estudios sobre el impacto de la gestión del conocimiento y el capital intelectual por separado y en conjunto en varios tipos de innovación y en ambos casos el impacto es positivo, pero no se ha encontrado el impacto sobre la innovación del modelo de negocio; por lo tanto, se identifica un vacío en la literatura que debería ser investigado empíricamente.
Classification JEL: O31, D83, M10.
Ten years of clinical experience with cyanoacrylate glue for venous access in a 1300-bed university hospital
Authors: Pittiruti Mauro , Annetta Maria Giuseppina , Marche Bruno , D’Andrea Vito , Scoppettuolo Giancarlo 
Published: June 2022

ABSTRACT
In the past decade, cyanoacrylate glue has been progressively introduced into the clinical practice of venous access devices used for different purposes. Glue has been used to increase device stabilisation (to reduce the risk of catheter dislodgement), to seal the exit site (to both reduce local bleeding and decrease the risk of bacterial contamination) and to close skin incisions required for the insertion of tunnelled catheters or totally implanted venous ports. For many of these purposes, the efficacy and cost-effectiveness of cyanoacrylate glue has been demonstrated, while some indications are still controversial. This article reports on 10 years of clinical experience with cyanoacrylate glue in a large university hospital, and provides a narrative review of the scientific evidence on the benefits of glue in venous access that has been accumulating over the past decade.