bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of body composition with regional brain volumes and white matter microstructure in very preterm infants
Authors: Bell Katherine Ann , Matthews Lillian G , Cherkerzian Sara , Prohl Anna K , Warfield Simon K , Inder Terrie E , Onishi Shun , Belfort Mandy B 
Published: January 2022

ObjectiveTo determine associations between body composition and concurrent measures of brain development including (1) Tissue-specific brain volumes and (2) White matter microstructure, among very preterm infants at term equivalent age.DesignProspective observational study.SettingSingle-centre academic level III neonatal intensive care unit.PatientsWe studied 85 infants born <33 weeks’ gestation.MethodsAt term equivalent age, infants underwent air displacement plethysmography to determine body composition, and brain MRI from which we quantified tissue-specific brain volumes and fractional anisotropy (FA) of white matter tracts. We estimated associations of fat and lean mass Z-scores with each brain outcome, using linear mixed models adjusted for intrafamilial correlation among twins and potential confounding variables.ResultsMedian gestational age was 29 weeks (range 23.4–32.9). One unit greater lean mass Z-score was associated with larger total brain volume (10.5 cc, 95% CI 3.8 to 17.2); larger volumes of the cerebellum (1.2 cc, 95% CI 0.5 to 1.9) and white matter (4.5 cc, 95% CI 0.7 to 8.3); and greater FA in the left cingulum (0.3%, 95% CI 0.1% to 0.6%), right uncinate fasciculus (0.2%, 95% CI 0.0% to 0.5%), and right posterior limb of the internal capsule (0.3%, 95% CI 0.03% to 0.6%). Fat Z-scores were not associated with any outcome.ConclusionsLean mass—but not fat—at term was associated with larger brain volume and white matter microstructure differences that suggest improved maturation. Lean mass accrual may index brain growth and development.
The Canadian National Vaccine Safety Network: surveillance of adverse events following immunisation among individuals immunised with the COVID-19 vaccine, a cohort study in Canada
Authors: Bettinger Julie A , Sadarangani Manish , De Serres Gaston , Valiquette Louis , Vanderkooi Otto G , Kellner James D , Muller Matthew P , Top Karina A , Isenor Jennifer E , McGeer Allison , Marty Kimberly 
Published: January 2022

IntroductionCOVID-19 vaccines require enhanced safety monitoring after emergency approval. The Canadian National Vaccine Safety Network monitors the safety of COVID-19 vaccines and provides enhanced monitoring for healthy, auto-immune, immunocompromised, pregnant and breastfeeding populations and allows for the detection of safety signals.Methods and analysisOnline participant reporting of health events in vaccinated and unvaccinated individuals 12 years of age and older is captured in three surveys: 1 week after dose 1, 1 week after dose 2 and 7 months after dose 1. Medically attended events are followed up by telephone. The number, percentage, rate per 10 000 and incident rate ratios with 95% CIs are calculated by health event, vaccine type, sex and in 10-year age groups.Ethics and disseminationEach study site has Research Ethics Board approvals for the project (UBC Children’s & Women’s, CIUSSS de l'Estrie—CHUS, Health PEI, Conjoint Health Research Ethics Board, University of Calgary and Alberta Health Services, IWK Health, Unity Health Toronto and CHU de Québec-Université Laval Research Ethics Boards). Individuals are invited to participate in this active surveillance and electronic consent is given before proceeding to each survey. Weekly reports are shared with public health and posted on the study website. At least one peer-reviewed manuscript is produced.
Patient experience of diagnosis and management of spontaneous intracranial hypotension: a cross-sectional online survey
Authors: Cheema Sanjay , Joy Clare , Pople Jenny , Snape-Burns Jessica , Trevarthen Tamsin , Matharu Manjit 
Published: January 2022

ObjectivesTo present the results of a survey of patients with spontaneous intracranial hypotension (SIH) secondary to spinal cerebrospinal fluid (CSF) leak, documenting the patient experience of its diagnosis and management as well as quantifying its impact on quality of life.DesignA cross-sectional anonymous online survey was designed in conjunction with the CSF Leak Association patient charity. The survey included questions on diagnosis, investigations and treatments received, as well as validated disability and quality of life questionnaires.ParticipantsSixty-four patients with a confirmed diagnosis of SIH who were receiving treatment within the UK were included in the analysis. The mean age was 42.8 years, 94% were female and 43 had ongoing symptoms of SIH.ResultsPatients who presented to their general practitioner with symptoms of SIH were seen an average three times before being referred to a specialist, and in just under half of patients, the diagnosis was not made by the first specialist they saw. There was variability in which investigations were performed and how urgently they were organised. The mean EuroQol (EQ-5D-5L) Visual Analogue Scale score was 36.4/100 and median Headache Impact Test-6 score was 68/78 (very severe impact). More than half of the respondents reported that they had to amend work duties due to SIH, more than a quarter reported that they had lost their job and two-thirds reported that their condition had affected their financial health. Only 23.4% of patients felt that they had received enough help and advice to manage their pain due to SIH.ConclusionsSIH is a highly disabling disorder, affecting multiple domains, including pain, mobility, activities of daily living, financial circumstances and employment. Diagnostic delay and misdiagnosis are common, and currently there is a lack of consistency in the investigation and management of SIH in the UK.
Child pedestrian and cyclist injuries, and the built and social environment across Canadian cities: the Child Active Transportation Safety and the Environment Study (CHASE)
Authors: Rothman Linda , Schwartz Naomi , Cloutier Marie-Soleil , Winters Meghan , Macarthur Colin , Hagel Brent E , Macpherson Alison K , El Amiri Nisrine , Fuselli Pamela , Howard Andrew William 
Published: January 2022

IntroductionTraffic injury is a leading and preventable cause of child death and disability, with child pedestrians and cyclists particularly vulnerable. Examining built environment correlates of child pedestrian and cyclist motor vehicle collisions (PCMVC) in different settings is needed to promote an evidence-based approach to road safety.MethodsWe conducted a cross-sectional study across multiple urban/suburban environments in Canada (Calgary, Toronto, Montreal, Laval, Peel Region). All public elementary schools were included (n=1030). We examined the role of land use/social environments, road environments and traffic safety interventions on the rates of child PCMVC within 1000 m of schools. Multivariable negative binomial regression was conducted for all cities and by individual city. In a subset of schools (n=389), we examined associations when controlling for active school transportation (AST).ResultsMean PCMVC rate per school ranged from 0.13 collisions/year in Peel to 0.35 in Montreal. Child PCMVC were correlated with land use, social and road environments and traffic safety interventions. In fully adjusted models, social and land use features remained the most important correlates. New immigrant population had the largest positive association with child PCMVC (incidence rate ratio (IRR): 1.26, 95% CI 1.06 to 1.50), while old housing (pre-1960) density was most protective (IRR: 0.83, 95% CI 0.77 to 0.90). AST was associated with PCMVC, but it had no effect on the relationships between PCMVC and other social/environmental correlates.ConclusionThe built environment and social factors influence rates of child PCMVC. Opportunities to reduce child PCMVC exist through modifications to city design and road environments and implementing traffic safety interventions.
Survival estimates of free-living arctic ground squirrels (Urocitellus parryii): effects of sex and biologging
Authors: Wilbur Sara M. , Deane Cody E. , Breed Greg A. , Buck C. Loren , Williams Cory T. , Barnes Brian M. 
Published: January 2022

Hibernation is associated with long lifespan: on average, hibernating mammals live 15% longer than nonhibernators of equivalent mass. We investigated how survival varies with sex, season, and the deployment of biologgers in arctic ground squirrels (Urocitellus parryii (Richardson, 1825)), a widely distributed northern hibernator. The duration of hibernation in arctic ground squirrels differs markedly by sex: females hibernate 30% longer each year than males, a behavioural trait that could positively affect female survival. Additionally, males engage in aggressive territorial and food cache defense in spring and fall, which may decrease survival in this sex. From 13 years of mark–recapture data, we estimated apparent survival of arctic ground squirrels in Arctic Alaska (USA) using Cormack–Jolly–Seber models in program MARK. We found that females had higher annual survival ([Formula: see text] (95% confidence interval (CI): 0.469, 0.913)) than males ([Formula: see text] (95% CI: 0.416, 0.670)), with a maximum observed lifespan (10 years) that exceeded that of males (6 years). We also show that biologger use and implantation did not significantly impact survival. Quantifying basic arctic ground squirrel demographics from this well-studied population illustrates how sex-specific hibernation parameters may influence lifespan differences in male and female arctic ground squirrels and provides support for the safety of biologging devices.
High-energy elastic diffractive scattering of nucleons in the framework of the two-Reggeon eikonal approximation (from U-70 to LHC)
Authors: Godizov A. A. 
Published: January 2022

AbstractElastic diffractive scattering of nucleons is described in terms of Regge-eikonal approach. It is demonstrated that, in a wide kinematic region (starting from the U-70 energies), the eikonal of proton–proton scattering can be approximated by the sum of two Reggeon exchange terms (namely, the so-called soft Pomeron and f-Reggeon contributions). The range of applicability of the considered approximation is determined. The predictive value of the proposed phenomenological scheme is verified.
Antioxidant and Cytotoxic Activity of a New Ferruginan A from Olea ferruginea: In Vitro and In Silico Studies
Authors: Shah Zafar Ali , Mujawah Adil A. H. , Ullah Irfan , Rauf Abdur , Rashid Umer , Khalil Anees Ahmed , Shah Syed Muhammad Mukarram , Pervaiz Aini , Shaheen Farzana , Al-Awthan Yahya S. , Qureshi Muhammad Nasimullah , Al-Duais Mohammed A. , Bahattab Omar , Almarhoon Zainab M. , Mabkhot Yahia N. , Mubarak Mohammad S. 
Published: January 2022

Studies of the ethyl acetate extract bark extract of Olea ferruginea led to the isolation of one new compound Ferruginan A (1) in addition to two known compounds, Ferruginan (2) and cycloolivil (3). Structures of the isolated compounds were confirmed by mass spectrometry (MS) and NMR spectral data. The ethyl acetate fraction and compounds (1–3) were evaluated against breast cancer cell line (MCF-7) and as antioxidants using the free radical scavenging assay. Results revealed that compound 2 exhibits significant antioxidant activity with an

I

C

50

value of 21.74 μg/mL. In addition, the ethyl acetate fraction showed good cytotoxic activity (79.31% inhibition at 250 μg/mL), whereas compounds 1–3 exerted mild cytotoxic activity (

I

C

50

=
8.03
–
12.01

μ
g
/
mL

) as compared to the standard (

I

C

50

=
4.41

μ
g
/
mL

) against MCF-7. Docking studies suggested that antioxidant activity is due to the chelation of compounds with copper present in the active site of tyrosinase. These results suggest that the extract exhibits considerable antioxidant activity, and the isolated compounds exert moderate anticancer activity.
Immunoglobulin E Sensitization to Mammalian Oligosaccharide Galactose-α-1,3 (α-Gal) Is Associated With Noncalcified Plaque, Obstructive Coronary Artery Disease, and ST-Segment–Elevated Myocardial Infarction
Authors: Vernon Stephen T. , Kott Katharine A. , Hansen Thomas , Finemore Meghan , Baumgart Karl W. , Bhindi Ravinay , Yang Jean , Hansen Peter S. , Nicholls Stephen J. , Celermajer David S. , Ward Michael R. , van Nunen Sheryl A. , Grieve Stuart M. , Figtree Gemma A. 
Published: January 2022

Background:
Treating known risk factors for coronary artery disease (CAD) has substantially reduced CAD morbidity and mortality. However, a significant burden of CAD remains unexplained. Immunoglobulin E sensitization to mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal) was recently associated with CAD in a small observational study. We sought to confirm that α-Gal sensitization is associated with CAD burden, in particular noncalcified plaque. Additionally, we sort to assess whether that α-Gal sensitization is associated with ST-segment–elevated myocardial infarction (STEMI)

Methods:
We performed a cross-sectional analysis of participants enrolled in the BioHEART cohort study. We measured α-Gal specific-immunoglobulin E antibodies in serum of 1056 patients referred for CT coronary angiography for suspected CAD and 100 selected patients presenting with STEMI, enriched for patients without standard modifiable risk factors. CT coronary angiograms were assessed using coronary artery calcium scores and segmental plaque scores.

Results:

α-Gal sensitization was associated with presence of noncalcified plaque (odds ratio, 1.62 [95% CI, 1.04–2.53],
P
=0.03) and obstructive CAD (odds ratio, 2.05 [95% CI, 1.29-3.25],
P
=0.002), independent of age, sex, and traditional risk factors. The α-Gal sensitization rate was 12.8-fold higher in patients with STEMI compared with matched healthy controls and 2.2-fold higher in the patients with STEMI compared with matched stable CAD patients (17% versus 1.3%,
P
=0.01 and 20% versus 9%,
P
=0.03, respectively).

Conclusions:
α-Gal sensitization is independently associated with noncalcified plaque burden and obstructive CAD and occurs at higher frequency in patients with STEMI than those with stable or no CAD. These findings may have implications for individuals exposed to ticks, as well as public health policy.

Registration:

URL:
https://www.anzctr.org.au
; Unique identifier: ACTRN12618001322224.
Apo(a) and ApoB Interact Noncovalently Within Hepatocytes: Implications for Regulation of Lp(a) Levels by Modulation of ApoB Secretion
Authors: Youssef Amer , Clark Justin R. , Marcovina Santica M. , Boffa Michael B. , Koschinsky Marlys L. 
Published: January 2022

Background:
Elevated plasma Lp(a) (lipoprotein(a)) levels are associated with increased risk for atherosclerotic cardiovascular disease and aortic valve stenosis. However, the cell biology of Lp(a) biosynthesis remains poorly understood, with the locations of the noncovalent and covalent steps of Lp(a) assembly unclear and the nature of the apoB-containing particle destined for Lp(a) unknown. We, therefore, asked if apo(a) and apoB interact noncovalently within hepatocytes and if this impacts Lp(a) biosynthesis.

Methods:
Using human hepatocellular carcinoma cells expressing 17K (17 kringle) apo(a), or a 17KΔLBS7,8 variant with a reduced ability to bind noncovalently to apoB, we performed coimmunoprecipitation, coimmunofluorescence, and proximity ligation assays to document intracellular apo(a):apoB interactions. We used a pulse-chase metabolic labeling approach to measure apo(a) and apoB secretion rates.

Results:

Noncovalent complexes containing apo(a)/apoB are present in lysates from cells expressing 17K but not 17KΔLBS7,8, whereas covalent apo(a)/apoB complexes are absent from lysates. 17K and apoB colocalized intracellularly, overlapping with staining for markers of endoplasmic reticulum trans-Golgi, and early endosomes, and less so with lysosomes. The 17KΔLBS7,8 had lower colocalization with apoB. Proximity ligation assays directly documented intracellular 17K/apoB interactions, which were dramatically reduced for 17KΔLBS7,8. Treatment of cells with PCSK9 (proprotein convertase subtilisin/kexin type 9) enhanced, and lomitapide reduced, apo(a) secretion in a manner dependent on the noncovalent interaction between apo(a) and apoB. Apo(a) secretion was also reduced by siRNA-mediated knockdown of
APOB
.

Conclusions:
Our findings explain the coupling of apo(a) and Lp(a)-apoB production observed in human metabolic studies using stable isotopes as well as the ability of agents that inhibit apoB biosynthesis to lower Lp(a) levels.
2. Coloniality and Decoloniality in the Global South Higher-Education Context
Authors: Martinez-Vargas Carmen 
Published: January 2022

This chapter explores the complexities of investigating participatory approaches as a research field. The chapter divides the field into four major research areas (industrial, development, Indigenous, and educational) in order to clarify the diverse foundational assumptions of different practices and their distinct theoretical grounds.
After the exploration of these branches, the major challenges for the field are summarised. The chapter investigates issues around individual/collective practices, the contested terms and application of participation in different practices, credibility and validity within the academic context, and the challenges arising from embracing diverse practices. This chapter focuses on the gaps between each of the four proposed branches and decoloniality, highlighting spaces where we might usefully introduce the Capabilities Approach as a theoretical frame. Thus, this chapter provides the starting point for a conceptualisation of participatory capabilities-based research, in order to resolve certain limitations of these four branches.
AERA5-Asia: A Long-Term Asian Precipitation Dataset (0.1°, 1-hourly, 1951–2015, Asia) Anchoring the ERA5-Land under the Total Volume Control by APHRODITE
Authors: Ma Ziqiang , Xu Jintao , Ma Yaoming , Zhu Siyu , He Kang , Zhang Shengjun , Ma Weiqiang , Xu Xiangde 
Published: January 2022

Abstract
Accurate long-term precipitation information is critical for understanding the mechanisms behind how precipitation couples with Earth’s water fluxes, energy balances, and biogeochemical cycles across space–time scales under the changing climate. This study proposes a novel approach [daily total volume controlled merging and disaggregation algorithm (DTVCMDA)] for generating a new long-term precipitation dataset, AERA5-Asia (0.1°, 1-hourly, 1951–2015, Asia; “AERA5” is a combination of the “A” from APHRODITE and the “ERA5” from ERA5-Land), by comprehensively considering the characteristics of the high spatiotemporal resolutions and continuity of the ERA5-Land dataset and the high quality of the APHRODITE dataset. The main conclusions include, but are not limited to, the following: 1) AERA5-Asia provides time series of precipitation of sufficient resolutions, length, consistency, continuity, and quality over Asia. 2) AERA5-Asia substantially outperforms ERA5-Land and IMERG-Final in terms of both magnitudes and occurrences of precipitation events in Mainland China, especially the systematic biases. For instance, the bias of ERA5-Land, IMERG-Final, and AERA5-Asia against ground gauge-based observations in Mainland China are ∼20%, ∼11%, and ∼5%, respectively. 3) AERA5-Asia performs notably better than ERA5-Land and IMERG-Final against ground gauge-based observations in regional extreme rainfall systems (e.g., two typhoon events, Trami and Usagi). 4) AERA5-Asia should prove to be a useful precipitation dataset for addressing various key climatological and hydrological research questions that require precipitation data with longer spans and finer resolutions (0.1°, 1-hourly).
The Future Intensification of the North Atlantic Winter Storm Track: The Key Role of Dynamic Ocean Coupling
Authors: Chemke Rei , Zanna Laure , Orbe Clara , Sentman Lori T. , Polvani Lorenzo M. 
Published: January 2022

AbstractClimate models project an intensification of the wintertime North Atlantic Ocean storm track, over its downstream region, by the end of this century. Previous studies have suggested that ocean–atmosphere coupling plays a key role in this intensification, but the precise role of the different components of the coupling has not been explored and quantified. In this paper, using a hierarchy of ocean coupling experiments, we isolate and quantify the respective roles of thermodynamic (changes in surface heat fluxes) and dynamic (changes in ocean heat flux convergence) ocean coupling in the projected intensification of North Atlantic transient eddy kinetic energy (TEKE). We show that dynamic coupling accounts for nearly all of the future TEKE strengthening as it overcomes the much smaller effect of surface heat flux changes to weaken the TEKE. We further show that by reducing the Arctic amplification in the North Atlantic, ocean heat flux convergence increases the meridional temperature gradient aloft, causing a larger eddy growth rate and resulting in the strengthening of North Atlantic TEKE. Our results stress the importance of better monitoring and investigating the changes in ocean heat transport, for improving climate change adaptation strategies.Significance StatementBy the end of this century, the North Atlantic Ocean storm track is projected to intensify on its eastward flank. Such intensification will have large societal impacts, mostly over western Europe. Thus, it is critical to better understand the mechanism underlying the intensification of the storm track. Here we investigate the role of ocean coupling in the future intensification of the North Atlantic storm track and find that ocean heat transport processes are responsible for the strengthening of the storm track. Our results suggest that better monitoring the changes in ocean heat transport will hopefully improve climate change adaption strategies.
Climate Sensitivity is Sensitive to Changes in Ocean Heat Transport
Authors: Singh Hansi , Feldl Nicole , Kay Jennifer E. , Morrison Ariel L. 
Published: January 2022

AbstractDo changes in ocean heat transport (OHT) that occur with CO2forcing, impact climate sensitivity in Earth system models? Changes in OHT with warming are ubiquitous in model experiments: when forced with CO2, such models exhibit declining poleward OHT in both hemispheres at most latitudes, which can persist over multicentennial time scales. To understand how changes in OHT may impact how the climate system responds to CO2forcing, particularly climate sensitivity, we perform a series of Earth system model experiments in which we systematically perturb OHT (in a slab ocean, relative to its preindustrial control climatology) while simultaneously doubling atmospheric CO2. We find that equilibrium climate sensitivity varies substantially with OHT. Specifically, there is a 0.6 K decrease in global mean surface warming for every 10% decline in poleward OHT. Radiative feedbacks from CO2doubling, and the warming attributable to each of them, generally become more positive (or less negative) when poleward OHT increases. Water vapor feedback differences account for approximately half the spread in climate sensitivity between experiments, while differences in the lapse rate and surface albedo feedbacks account for the rest. Prescribed changes in OHT instigate opposing changes in atmospheric energy transport and the general circulation, which explain differences in atmospheric water vapor and lapse rate between experiments. Our results show that changes in OHT modify atmospheric radiative feedbacks at all latitudes, thereby driving changes in equilibrium climate sensitivity. More broadly, they demonstrate that radiative feedbacks are not independent of the coupled (atmosphere and ocean) dynamic responses that accompany greenhouse gas forcing.