bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Prostate Imaging and Reporting Data System V2.0 and V2.1 for Evaluation of Transition Zone Lesions: A 5-Reader 202-Patient Analysis
Authors: Kim Nancy , Kim Sooah , Prabhu Vinay , Shanbhogue Krishna , Smereka Paul , Tong Angela , Anthopolos Rebecca , Taneja Samir S. , Rosenkrantz Andrew B. 
Published: April 2022

Objective
The aim of the study was to compare the distribution of Prostate Imaging and Reporting Data System (PI-RADS) scores, interreader agreement, and diagnostic performance of PI-RADS v2.0 and v2.1 for transition zone (TZ) lesions.

Methods
The study included 202 lesions in 202 patients who underwent 3T prostate magnetic resonance imaging showing a TZ lesion that was later biopsied with magnetic resonance imaging/ultrasound fusion. Five abdominal imaging faculty reviewed T2-weighted imaging and high b value/apparent diffusion coefficient images in 2 sessions. Cases were randomized using a crossover design whereby half in the first session were reviewed using v2.0 and the other half using v2.1, and vice versa for the 2nd session. Readers provided T2-weighted imaging and DWI scores, from which PI-RADS scores were derived.

Results
Interreader agreement for all PI-RADS scores had κ of 0.37 (v2.0) and 0.26 (v2.1). For 4 readers, the percentage of lesions retrospectively scored PI-RADS 1 increased greater than 5% and PI-RADS 2 score decreased greater than 5% from v2.0 to v2.1. For 2 readers, the percentage scored PI-RADS 3 decreased greater than 5% and, for 2 readers, increased greater than 5%. The percentage of PI-RADS 4 and 5 lesions changed less than 5% for all readers. For the 4 readers with increased frequency of PI-RADS 1 using v2.1, 4% to 16% were Gleason score ≥3 + 4 tumor. Frequency of Gleason score ≥3 + 4 in PI-RADS 3 lesions increased for 2 readers and decreased for 1 reader. Sensitivity of PI-RADS of 3 or greater for Gleason score ≥3 + 4 ranged 76% to 90% (v2.0) and 69% to 96% (v2.1). Specificity ranged 32% to 64% (v2.0) and 25% to 72% (v2.1). Positive predictive value ranged 43% to 55% (v2.0) and 41% to 58% (v2.1). Negative predictive value ranged 82% to 87% (v2.0) and 81% to 91% (v2.1).

Conclusions
Poor interreader agreement and lack of improvement in diagnostic performance indicate an ongoing need to refine evaluation of TZ lesions.
Solitary Fibrous Tumor of the Spine: Imaging Grading Diagnosis and Prognosis
Authors: Shen Yiyuan , Ren Yan , Wang Weiwei , Wang Yin , Yang Yang , Wu Fei , Wang Junlong , Deng Yan , Liu Hanqiu 
Published: April 2022

Objective
This study aimed to investigate the imaging features and prognosis of spinal solitary fibrous tumors (SFTs) of different pathological grades.

Methods
The clinical features, computed tomography and magnetic resonance (MR) images, and follow-up data of 23 patients with SFTs were reviewed. The patients were divided into 3 groups according to their pathological manifestations: grade 1 (n = 3), grade 2 (n = 14), and grade 3 (n = 6). The following imaging features were recorded: location, computed tomography density/MR intensity, enhancement pattern, dural tail sign, adjacent bone remodeling, lobulation, and tumor size. The immunohistochemical (Ki-67/MIB-1) levels were also investigated. All parameters were statistically analyzed between grade 2 and 3 tumors.

Results
The Ki-67/MIB-1 index was markedly higher in grade 3 tumors than in grade 2 tumors (P < 0.001). All grade 1 lesions appeared hypointense on T2-weighted image, whereas grade 2 and 3 lesions appeared isointense or mildly hyperintense. There were significant differences in enhancement type and osteolytic bony destruction between grade 2 and 3 tumors (P < 0.05). However, no marked differences were found in the distribution of age, sex, location, MR signal, degree of enhancement, compressive bony absorption, dural tail sign, or maximum vertical/traverse diameter ratio. Malignant progression occurred less frequently in patients with grade 2 tumors than in those with grade 3 tumors, but the difference was not statistically significant.

Conclusions
Different grades of spinal SFTs have different degrees of proliferation and imaging features, especially grade 3 tumors, which show a heterogeneous enhancement pattern, osteolytic bony destruction, and a higher possibility of recurrence and metastasis.
Cotransplantation With Adipose Tissue–derived Stem Cells Improves Engraftment of Transplanted Hepatocytes
Authors: Yamana Hiroki , Inagaki Akiko , Imura Takehiro , Nakamura Yasuhiro , Nishimaki Hiroyasu , Katano Takumi , Ohashi Kazuo , Miyagi Shigehito , Kamei Takashi , Unno Michiaki , Goto Masafumi 
Published: April 2022

Background.
Hepatocyte transplantation is expected to be an alternative therapy to liver transplantation; however, poor engraftment is a severe obstacle to be overcome. The adipose tissue–derived stem cells (ADSCs) are known to improve engraftment of transplanted pancreatic islets, which have many similarities to the hepatocytes. Therefore, we examined the effects and underlying mechanisms of ADSC cotransplantation on hepatocyte engraftment.

Methods.
Hepatocytes and ADSCs were cotransplanted into the renal subcapsular space and livers of syngeneic analbuminemic rats, and the serum albumin level was quantified to evaluate engraftment. Immunohistochemical staining and fluorescent staining to trace transplanted cells in the liver were also performed. To investigate the mechanisms, cocultured supernatants were analyzed by a multiplex assay and inhibition test using neutralizing antibodies for target factors.

Results.
Hepatocyte engraftment at both transplant sites was significantly improved by ADSC cotransplantation (P < 0.001, P < 0.001). In the renal subcapsular model, close proximity between hepatocytes and ADSCs was necessary to exert this effect. Unexpectedly, ≈50% of transplanted hepatocytes were attached by ADSCs in the liver. In an in vitro study, the hepatocyte function was significantly improved by ADSC coculture supernatant (P < 0.001). The multiplex assay and inhibition test demonstrated that hepatocyte growth factor, vascular endothelial growth factor, and interleukin-6 may be key factors for the abovementioned effects of ADSCs.

Conclusions.
The present study revealed that ADSC cotransplantation can improve the engraftment of transplanted hepatocytes. This effect may be based on crucial factors, such as hepatocyte growth factor, vascular endothelial growth factor, and interleukin-6, which are secreted by ADSCs.
Pre–kidney Donation Pregnancy Complications and Long-term Outcomes
Authors: Helgeson Erika S. , Palzer Elise F. , Vock David M. , Porrett Paige , Sawinski Deirdre , Matas Arthur J. 
Published: April 2022

Background.
Hypertension and diabetes are contraindications for living kidney donation in young candidates. However, little is known about the long-term outcomes of women who had these pregnancy-related complications and subsequently became donors. In the general population, gestational hypertension (GHtn), preeclampsia/eclampsia, and gestational diabetes (GDM) are associated with long-term risks.

Methods.
Donors with the specified predonation complication were matched to contemporary control donors with pregnancies without the complication using nearest neighbor propensity score matching. Propensity scores were estimated using logistic regression with covariates for gravidity, blood pressure, glucose, body mass index, age, and creatinine at donation, donation year, race, relationship with recipient, and family history of disease. Long-term incidence of hypertension, diabetes, cardiovascular disease, and reduced renal function (estimated glomerular filtration rate [eGFR] <30, eGFR <45 mL/min/1.73 m2) were compared between groups using proportional hazards models.

Results.
Of 1862 donors with predonation pregnancies, 48 had preeclampsia/eclampsia, 49 had GHtn without preeclampsia, and 43 had GDM. Donors had a long interval between first pregnancy and donation (median, 18.5 y; interquartile range, 10.6–27.5) and a long postdonation follow-up time (median, 18.0; interquartile range, 9.2–27.7 y). GHtn was associated with the development of hypertension (hazard ratio, 1.89; 95% confidence interval, 1.26-2.83); GDM was associated with diabetes (hazard ratio, 3.04; 95% confidence interval, 1.33-6.99). Pregnancy complications were not associated with eGFR <30 or eGFR <45 mL/min/1.73 m2.

Conclusions.
Our data suggest that women with predonation pregnancy-related complications have long-term risks even with a normal donor evaluation. Donor candidates with a history of pregnancy-related complications should be counseled about these risks.
An Elo-type rating model for players and teams of variable strength
Authors: Düring Bertram , Fischer Michael , Wolfram Marie-Therese 
Published: April 2022

The Elo rating system, which was originally proposed by Arpad Elo for chess, has become one of the most important rating systems in sports, economics and gaming. Its original formulation is based on two-player zero-sum games, but it has been adapted for team sports and other settings. In 2015, Junca and Jabin proposed a kinetic version of the Elo model, and showed that under certain assumptions the ratings do converge towards the players’ strength. In this paper, we generalize their model to account for variable performance of individual players or teams. We discuss the underlying modelling assumptions, derive the respective formal mean-field model and illustrate the dynamics with computational results.This article is part of the theme issue ‘Kinetic exchange models of societies and economies’.
Opinion dynamics: public and private
Authors: Roy Subhadeep , Biswas Soumyajyoti 
Published: April 2022

We study here the dynamics of opinion formation in a society where we take into account the internally held beliefs and externally expressed opinions of the individuals, which are not necessarily the same at all times. While these two components can influence one another, their difference, both in dynamics and in the steady state, poses interesting scenarios in terms of the transition to consensus in the society and characterizations of such consensus. Here we study this public and private opinion dynamics and the critical behaviour of the consensus forming transitions, using a kinetic exchange model.
This article is part of the theme issue ‘Kinetic exchange models of societies and economies’.
Pretend play predicts receptive and expressive language trajectories in young children with autism
Authors: Vyshedskiy Andrey , Khokhlovich Edward 
Published: April 2022

AbstractThe effect of pretend play in 2 to 5-year-old children with ASD was investigated in the largest and the longest observational study to-date. Parents assessed the development of 7,069 children quarterly for three years on five subscales: combinatorial receptive language, expressive language, sociability, sensory awareness, and health. Pretend play was associated with superior developmental trajectories: 1.9-fold faster improvement of combinatorial receptive language (p<0.0001), 1.4-fold faster improvement of expressive language (p<0.0001), and 1.3-fold faster improvement of sensory awareness (p=0.0009). Pretend play had little effect on sociability and health. The strong association of pretend play with combinatorial receptive language remained significant even when controlling for expressive language. Similarly, the effect of pretend play on expressive language remained significant even when controlling for combinatorial receptive language. The effect of pretend play on combinatorial receptive language (but not on the expressive language) was stronger than the effects of seizures, sleep problems or high-TV exposure. The strong effect of pretend-play supports earlier studies indicating that it is an important stepping stone for language acquisition, particularly, the acquisition of combinatorial language.
Periodic Environmental Disturbance Drives Repeated Ecomorphological Diversification in an Adaptive Radiation of Antarctic Fishes
Authors: Parker Elyse , Zapfe Katerina L. , Yadav Jagriti , Frédérich Bruno , Jones Christopher D. , Economo Evan P. , Federman Sarah , Near Thomas J. , Dornburg Alex 
Published: April 2022

AbstractThe ecological theory of adaptive radiation has profoundly shaped our conceptualization of the rules that govern diversification. However, while many radiations follow classic early burst patterns of diversification as they fill ecological space, the longer-term fates of these radiations depend on many factors, such as climatic stability. In systems with periodic disturbances, species-rich clades can contain nested adaptive radiations of subclades with their own distinct diversification histories, and how adaptive radiation theory applies in these cases is less clear. Here, we investigated patterns of ecological and phenotypic diversification within two iterative adaptive radiations of cryonotothenioid fishes in Antarctica’s Southern Ocean: crocodile icefishes and notoperches. For both clades, we observe evidence of repeated diversification into disparate regions of trait space between closely related taxa and into overlapping regions of trait space between distantly related taxa. We additionally find little evidence that patterns of ecological divergence are correlated with evolution of morphological disparity, suggesting that these axes of divergence may not be tightly linked. Finally, we reveal evidence of repeated convergence in sympatry that suggests niche complementarity. These findings reflect the dynamic history of Antarctic marine habitats, and may guide hypotheses of diversification dynamics in environments characterized by periodic disturbance.
multiplestressR: An R package to analyse factorial multiple stressor data using the additive and multiplicative null models
Authors: Burgess Benjamin J. , Murrell David J. 
Published: April 2022

AbstractGlobally, ecosystems are being affected by multiple simultaneous stressors (also termed drivers, factors, or perturbations). While the effects of single stressors are becoming increasingly well understood, there remains substantial uncertainty regarding how multiple stressors may interact to affect ecosystems. Accordingly, there is substantial interest in documenting how stressors combine to impact individuals through to entire communities. Indeed, understanding how stressors interact represents one of the grand challenges currently facing ecologists and conservationists.Popular methods used to classify stressor interactions comprise multiple steps, including complex mathematical equations. Accordingly, there is the potential for errors to occur at multiple points, any of which can result in erroneous conclusions being drawn. Furthermore, there are frequently minor methodological differences between studies which may limit, or even prevent, direct comparisons of their results from being made.Here, we introduce the multiplestressR R package, a statistical tool which addresses the above issues. The package allows researchers to easily conduct a rigorous analysis of their multiple stressor data and provides results which are simple to interpret. The multiplestressR package can implement either the additive or multiplicative null model using iterations of these tools which are commonplace within multiple stressor ecology. The multiplestressR package can classify interactions as being synergistic, antagonistic, reversal, or null and requires minimal experience in either R or statistics to implement. Additionally, we provide example R code which can be easily modified to analysis any given factorial multiple stressor dataset. Indeed, widespread use of this software will allow for an easier and more robust comparison of results. Ultimately, we hope that the multiplestressR package will provide a stronger understanding of how stressors combine to affect individuals, populations, communities, and ecosystems.
Do sustainability committee characteristics affect CSR performance? Evidence from India
Authors: Jarboui Anis , Dammak Ben Hlima Nada , Bouaziz Dhouha 
Published: April 2022

PurposeThis study aimed to investigate the effect of sustainability committee (SC) characteristics (size, independence, the number of meetings, and expertise) on corporate social responsibility (CSR) performance in the Indian context.Design/methodology/approachThis research measures the CSR performance of 60 Indian non-financial firms listed on the Bombay Stock Exchange (BSE) over the period 2014 to 2019 using the ASSET4 environmental, social, and governance database. The authors resorted to fixed-effect panel regressions to capture the individual effect present in the data.FindingsThe results show that CSR performance is positively and significantly influenced by SC independence, size, and expertise. However, the number of SC meetings does not affect CSR performance. The results also demonstrate that CSR performance is positively and significantly associated with board independence.Research limitations/implicationsThis paper adds to the existing literature by examining the effect of SC characteristics on the firms' CSR performance in India as one of the oldest stock markets in the world, which would help test the validity of the agency and stakeholder theories in an old and big emerging market context.Practical implicationsThe findings allow managers to understand the mechanisms affecting CSR performance and how the characteristics of the SC can participate in its growth and development. Moreover, this study has implications for researchers, suggesting that future CSR studies should take into account the SC characteristics as potential determinants that explain CSR, such as CSR activities and CSR practices and strategies.Originality/valueThe present research contributes to the literature by investigating the effect of SC characteristics on the firms' CSR performance, thereby providing additional evidence on the issue. Several previous studies have examined the link between corporate governance and CSR performance with a focus on external oversight mechanisms, namely institutional ownership or analyst coverage or internal oversight mechanisms, such as board gender composition, board independence, separation of board Chairperson and CEO roles, and the existence of SC on the board, but these studies did not examine the SC characteristics. The present research fills the gap.
End of libraries/renaissance in the “peer-to-peer sharing economy” revolution age? Librarians of the future educating for a sustainable world
Authors: Hernandez-Carrion Jose Rodolfo 
Published: April 2022

Purpose
Libraries face an uncertain situation in present times of the “digital revolution” while every single sector moved online. The purpose of this paper is to search and propose potential library actions as response to the challenge of the peer-to-peer (p2p) sharing platform revolution in business models, a revolution to gain efficiency and to protect the environment.

Design/methodology/approach
This research focused on integrating economics and library concepts based on a selective literature review and real-world interaction. The main concern is to connect library possibilities with the emergence of p2p digital platforms, which has enabled individuals to make use of underused inventory via fee-based sharing, as a way of obtaining, giving or sharing access to goods and services. The authors balance the existing proposals to achieve how librarians can help.

Findings
This paper defines key types of potential applications for platform business models in the sharing economy promoted by librarians and describes their characteristics for the renaissance of the “New libraries”. First, “educating” society to face critically the disruptive change in networks of culture and information. Second, “growing” as key reference institutions and community service centres integrating “external” skills. Third, “promoting” the disruptive economy by creation or participation in digital platforms. Fourth, “creating” cooperative markets through social-economic currencies.

Originality/value
This research was carried out with the objective of determining how librarians contribute to sustainable development. All four proposals to implement represent possibilities that derive from the sharing economy approach at different levels of implementation according to the degree of commitment that librarians require to translate into specific actions.
Pay to view answers: determinants of listeners' payment decisions on social Q&A platforms
Authors: Sun Jing , Li Qian , Xu Wei , Wang Mingming 
Published: April 2022

PurposePaying to view others' answers is a new mode for question and answer (Q&A) platforms. The purpose is to build a model to explore the determinants of the number of listeners and further explore certain meaningful characteristics of the model in the context of different types of questions and answerers.Design/methodology/approachThe authors develop an empirical model and use real panel data to test the hypothesis. Specifically, cues from the answerer and from the question elicit the listener's trust in the answerer (including direct and indirect trust) and perceived value in the question (including intrinsic and extrinsic attributes), respectively.FindingsThe authors find that cues from answerers (experience for paid Q&As and popularity for free Q&As) and questions (length, sentence structure, value and number of likes) all have positive effects on the number of listeners. The impact of answerer authentication is more significant than the popularity of free Q&As. Moreover, the length of the question matters only for subjective questions, while sentence structure matters only for objective questions. In addition, the answerer's own attributes and the behavior and feedback of others have greater impacts when the answerer is below average in popularity.Originality/valueThe authors summarize the unique features of the mode of paying to view others' answers in contrast with the traditional mode of paid Q&As. In addition, the authors focus on the characteristics of the question (including the subjectivity and the sentence structure of the question), a topic which has not been studied previously. Our research provides a reference for exploring user behavior patterns. The practical implications for knowledge platforms are also concretely described.
Disruptions to agricultural activities, income loss and food insecurity during the COVID-19 pandemic: evidence from farm households in a developing country
Authors: Thanh Pham Tien , The Duy Duong , Bao Duong Pham 
Published: April 2022

PurposeIn the early stage of the COVID-19 pandemic, Vietnam imposed many drastic restrictions to curb the outbreak of this virus. Such restrictions interrupted the normal functioning of various economic sectors, including agriculture. This research examined disruptions to agricultural activities, income loss and perceived food insecurity among farm households during the pandemic, and then explored the relationships among these economic factors.Design/methodology/approachHousehold data from Vietnam and Generalized Structural Equation Model (GSEM) were used for empirical analysis.FindingsDescriptive analyses found that only a small proportion of farm households suffered from the COVID-19 disruptions to their agricultural activities, a large percentage experienced income loss, and a medium number were worried about their food insecurity. GSEM results also revealed that the COVID-19 disruptions to agricultural activities significantly increased the likelihood of worrying about food insecurity, mediated by income loss.Research limitations/implicationsDue to data limitations, the authors could not use better indicators to define and measure the variables of interest (e.g. COVID-19 disruptions to agricultural activities, income loss and food insecurity). Another similar concern was that our models did not account for unobservables, causing some estimation biases.Originality/valueThis research is among the first attempts that examined the direct and indirect (mediated by income loss) effects of the COVID-19 disruptions to agricultural activities on food insecurity.