bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goals Form: Reliability, validity, and clinical utility of an idiographic goal‐focused measure for routine outcome monitoring in psychotherapy
Authors: Cooper Mick , Xu Dan 
Published: April 2022

AbstractObjectiveThis study aimed to assess the reliability, validity, and clinical utility of an idiographic, goal‐focused patient‐reported outcome measure: The Goals Form.MethodsData were analyzed from 88 participants, across three samples, who had participated in collaborative–integrative psychotherapy at university‐based clinics in the UK. The samples were approximately 70% female with mean age of 30 years old.ResultsThe psychometric properties of the Goals Form were generally good. Noncompletion of individual items was low, temporal stability tended to be at target levels, and mean change scores showed moderate to good convergent validity against measures of psychological distress. The measure appeared sensitive to change in psychotherapy and was experienced by most patients as helpful.ConclusionsThe Goals Form shows acceptable psychometric and clinical properties for routine outcome monitoring in psychotherapy.
Histopathological changes in root and stem of mungbean exposed to Macrophomina phaseolina and dry biomass of Chenopodium quinoa
Authors: Khan Iqra Haider , Javaid Arshad 
Published: April 2022

AbstractMungbean production is affected by a fungal pathogen Macrophomina phaseolina. A pot experiment was carried out to check the effect of quinoa (Chenopodium quinoa Willd.) dry biomass on the histopathological features of mungbean exposed to M. phaseolina. For this, 1%, 2% and 3% (wt/wt) of C. quinoa dry biomass was mixed in the soil inoculated with M. phaseolina. The highest disease incidence (36%) was recorded in the positive control (only M. phaseolina). Different treatments of quinoa dry mass reduced disease incidence to 4–7%. After 4 weeks of germination, stem and root sections were stained in phloroglucinol‐HCl, ferric chloride and Lugol's iodine stains for the detection of lignin, polyphenols and starch granules, respectively, and studied under light microscope. Plants of positive control showed damaged cells, and heavy deposition of lignin, phenolics and starch granules as compared to plants of the negative control and those grown in the soil amended with different doses of dry biomass of quinoa. For better understanding, plant root and stem sections were studied under a scanning electron microscope. Plant sections from positive control exhibited the presence of M. phaseolina sclerotial bodies and hyphal growth, whereas in negative control normal cell structures were observed. However, C. quinoa amended stem and root sections revealed the presence of high gel deposition with normal cell structures and no pathogen establishment. This study concludes that application of C. quinoa is an effective and natural remedy to activate the resistance mechanism in plants and to combat the adverse effects of M. phaseolina.Highlights
Macrophomina phaseolina causes charcoal rot in mungbean.
Chenopodium quinoa amendment significantly reduced incidence of charcoal rot disease.
M. phaeolina increased concentrations of polyphenols, lignin and starch granules in mungbean.
Patient falls in the operating room setting: An analysis of reported safety events
Authors: Tan Joy , Krishnan Sindhu , Vacanti Joshua C. , Wheeler Kimberly K. , Giovannini Sheila T. , Pimentel Marc P. , Urman Richard D. 
Published: April 2022

AbstractIntroduction: Patient falls are a preventable public health problem, and they are among the most reported safety incidents in the hospital. We used a hospital safety reporting system to examine the nature of reported falls in the perioperative setting at an academic tertiary center.Methods: In this retrospective study, reports of perioperative safety events listed as “Falls” between 2014 and 2020 were analyzed for severity level and specific event type.Results: Out of 8337 safety reports from 2014 to 2020, 86 were “fall” related (1%). The most common “fall” event type was “ambulating with assistance and the severity level reported was mainly level 1 (no harm, did reach patient, 63%) followed by level 2 (temporary or minor harm, 28%). One of the most frequently reported types of perioperative falls was from a bed or stretcher (15% of falls)”.Conclusions: Our safety data reporting system identified falls as a safety event that causes patient harm in the perioperative setting that could be preventable with a multifaceted interdisciplinary approach. Risk managers can use these data to implement strategies to reduce falls such as creating screening protocols to identify high‐risk patients, educating and training healthcare personnel, and optimizing operating room, hospital, and equipment design.
Investigation and long‐term monitoring of the presence of neutralizing antibody in patients with COVID‐19 disease of different clinical severity
Authors: Kaygusuz Sedat , Korukluoğlu Gülay , Coşgun Yasemin , Şahin Ömer , Arslan Ferhat 
Published: April 2022

AbstractUnderstanding the immune responses elicited by severe acute respiratory syndrome virus (SARS‐CoV‐2) infection is critical to public health policy and vaccine development and prevention of reinfections for COVID‐19. It is important to know the neutralizing capacity of antibodies and to monitor their persistence. Patients with COVID‐19 were divided into four groups (severe‐critical, moderate, mild, and asymptomatic) according to their clinical severity. Antibodies against SARS‐CoV‐2 spike viral surface protein were investigated by ELISA method 3 and 9 months after the onset of the disease. Neutralizing antibody (NAb) response was evaluated by microneutralization test. Patients who received at least two doses of COVID‐19 vaccine after illness were enrolled. SARS‐CoV‐2 immunoglobulin G (IgG) and NAb titers were shown to be strongly correlated with disease severity. Anti‐SARS‐CoV‐2 IgG and NAb levels were found to be compatible with each other. After 9 months of follow‐up, both IgG and NAb levels continued unabated in individuals who had the disease. In individuals who received at least two doses of the vaccine, these levels increased, except for severe‐critical patients. High levels of anti‐SARS‐CoV‐2 IgG are indicative, as it is difficult to investigate NAb in routine laboratories. At the same time, it can be predicted that this period may be much longer if it continues for at least 9 months and is reinforced with vaccination.
Photobiomodulation therapy's effects on cardiac fibrosis activation after experimental myocardial infarction
Authors: Feliciano Regiane dos S. , Manchini Martha T. , Atum Allan L. B. , da Silva Gabriel Almeida , Antônio Ednei L. , Serra Andrey J. , Tucci Paulo J. F. , Andrade de Mello Ramon , Chavantes Maria C. , Baltatu Ovidiu C. , Silva Júnior José A. 
Published: April 2022

AbstractIntroductionIschemic heart disease is the leading cause of death worldwide, and interventions to reduce myocardial infarction (MI) complications are widely researched. Photobiomodulation therapy (PBMT) has altered multiple biological processes in tissues and organs, including the heart.ObjectivesThis study aimed to assess the temporal effects of PBMT on cardiac fibrosis activation after MI in rats. In this proof‐of‐concept study, we monitored the change in expression patterns over time of genes and microRNAs (miRNAs) involved in the formation of cardiac fibrosis post‐MI submitted to PBMT.Materials and MethodsExperimental MI was induced, and PBMT was applied shortly after coronary artery ligation (laser light of wavelength 660 nm, 15 mW of power, energy density 22.5 J/cm2, 60 seconds of application, irradiated area 0.785 cm2, fluence 1.1 J/cm2). Ventricular septal samples were collected at 30 minutes, 3, 6, 24 hours, and 3 days post‐MI to determine temporal PBMT's effects on messenger RNA (mRNA) expression associated with cardiac fibrosis activation and miRNAs expression.ResultsPBMT, when applied after ischemia, reversed the changes in mRNA expression of myocardial extracellular matrix genes induced by MI. Surprisingly, PBMT modified cardiac miRNAs expression related to fibrosis replacement in the myocardium. Expression correlations between myocardial mRNAs were assessed. The correlation coefficient between miRNAs and target mRNAs was also determined. A positive correlation was detected among miR‐21 and transforming growth factor beta‐1 mRNA. The miR‐29a expression negatively correlated to Col1a1, Col3a1, and MMP‐2 mRNA expressions. In addition, we observed that miR‐133 and Col1a1 mRNA were negatively correlated.ConclusionThe results suggest that PBMT, through the modulation of gene transcription and miRNA expressions, can interfere in cardiac fibrosis activation after MI, mainly reversing the signaling pathway of profibrotic genes.
Bioprinting of Cell‐Laden Hydrogels onto Titanium Alloy Surfaces to Produce a Bioactive Interface
Authors: Kotlarz Marcin , Ferreira Ana Marina , Gentile Piergiorgio , Dalgarno Kenneth 
Published: April 2022

AbstractThe surface of metal implants serves as a powerful signaling cue for cells. Its properties play an essential role in stabilizing the bone–implant interface and facilitating the early osseointegration by encouraging bone deposition on the surface. However, effective strategies to deliver cells to the metal surfaces are yet to be explored. Here, a bioprinting process, called reactive jet impingement (ReJI), is used to deposit high concentrations (4 × 107 cells mL−1) of mesenchymal stromal cells (MSCs) within hydrogel matrices directly onto the titanium alloy surfaces that vary in surface roughness and morphology. In this proof‐of‐concept study, cell–hydrogel–metal systems are fabricated with the aim of enhancing bioactivity through delivering MSCs in hydrogels at the bone–implant interface. These results show that the high cell concentrations encourage quick cell–biomaterial interactions at the hydrogel–metal surface interface, and cell morphology is influenced by the surface type. Cells migrate from the hydrogels and deposit mineralized matrix rich in calcium and phosphorus on the titanium alloy surfaces. The authors demonstrate that ReJI bioprinting is a promising tool to deliver cells in a 3D environment before implantation that can be used when developing a new generation of medical devices for bone tissue engineering.
Effect of Stereochemistry and Hydrophobicity on the Self‐Assembly of Phe‐Phe‐Nucleoside Conjugates
Authors: Tiwari Om Shanker , Ganesh Krishna N. , Gazit Ehud 
Published: April 2022

AbstractMolecular self‐assembly of the minimal diphenylalanine (Phe‐Phe) peptide building block shows unique morphological organizations and potential utility in biochemistry and biomaterials applications. Furthermore, the molecular engineering of nucleoside‐conjugated Phe‐Phe scaffolds allows the formation of diverse architectures with tunable biophysical properties. While the self‐assembly of homochiral l‐dipeptides is well characterized, stereochemistry is known to determine the conformation, which also governs self‐assembly through molecular packing effects. Here, the effect of stereochemistry and hydrophobicity on Phe‐Phe nucleoside conjugates using all four diastereomers [(l)Phe‐(l)Phe, (d)Phe‐(dPhe, (l)Phe‐(d)Phe, and (d)Phe‐(l)Phe] of Phe‐Phe conjugates is systematically studied. The homochiral peptides form well‐defined nanorods while the heterochiral dipeptides do not form any regular structures. Since heterocyclic nucleobases can self‐assemble through hydrogen‐bonded complementary base‐pairing, the self‐assembly of chiral nucleoside‐conjugated Phe‐Phe peptides is examined. All conjugated Phe‐Phe peptides form seamless spherical particles. The completely or partially deprotected peptides do not assemble to any defined nanostructures suggesting that self‐assembly is governed by the precise hydrophobic/hydrophilic balance in the assembling units. Contact angle measurements of the diastereomeric peptides reveal a subtle difference in stereochemistry‐dependent molecular hydrophobicity. Taken together, it is revealed that the combination of chirality together with hydrophobic/hydrophilic balance within the peptides dictates the self‐assembly of Phe‐Phe dipeptide nucleoside conjugates.
Water‐Soluble Hyperbranched Polyamidoamine Bearing Viologen Groups toward Electrochromic/Electrofluorochromic Dual‐Mode Aqueous Phase Devices
Authors: Zhao Jiaxin , Zhou Mingjuan , Zhang Yingchao , Berda Erik B. , Chao Danming 
Published: April 2022

AbstractThe health and environmental concerns drive the exploration of electro‐optical materials featuring aqueous processability and environmental friendliness. This work presents a water‐soluble electroactive hyperbranched polyamidoamine toward electrochromic (EC)/electrofluorochromic (EFC) dual‐mode aqueous phase devices. The resultant polymer bearing viologen groups exhibit reversible electroactivity and desirable EC properties (ΔT% = 71.7%, coloration efficiency (CE) = 216 cm2 C−1). The aggregation‐induced quenching as well as the energy transfer between the electroactive viologen groups and autofluorescent tertiary amine units results in a simultaneous EFC behavior with acceptable fluorescence contrast (on/off = 8.5) and moderate switching speed (22.9/12.5 s). Furthermore, a reflective/emissive dual‐mode aqueous phase device is manufactured readily based on the resultant polymer, which displays a simultaneous EC and EFC performance with high optical contrast (ΔT% = 92%), moderate fluorescence contrast (4.5), competitive CE (108 cm2 C−1), and low switching voltage of −1.4 V.
Corporate social responsibility and perceived fairness of price increases
Authors: Sipilä Jenni , Alavi Sascha , Edinger‐Schons Laura Marie , Müller Urs , Habel Johannes 
Published: April 2022

AbstractConsumers care about the fairness of companies both in terms of corporate social responsibility (CSR) engagement and the fairness of prices. However, the interplay between these domains is not yet well understood. Therefore, this study examines how consumers’ perceptions of CSR engagement affect their perceived price fairness following a price increase. Drawing on cue‐utilization and expectancy disconfirmation theory, the authors propose that perceived CSR engagement exacerbates the negative effect of a price increase on perceived price fairness, because perceived CSR engagement increases consumers’ price fairness expectations which are violated through price increases. These propositions are tested in three experimental studies with samples consisting of approximately 3000 customers of a global furniture manufacturer and retailer (Study 1), as well as participants acquired through a self‐administered online consumer panel (Study 2) and Prolific (Study 3). The experiments yield support for the hypothesized effects and reveal CSR skepticism as a critical boundary condition. The findings extend existing literature on the effects of perceived CSR engagement and pricing on consumer reactions by examining the role of perceived CSR engagement in shaping consumer reactions to price increases and by establishing consumers’ price fairness expectations as the central psychological mechanism.
Dual Responsive Molecular‐Arm Modified Single Enzyme Molecules for Efficient Cellulose Hydrolysis
Authors: Zhu Xing , Fan Mingliang , Cui Tianyu , Du Chenxi , He Bin 
Published: April 2022

AbstractImmobilizing cellulase for improving its hydrolysis activity and recyclability is critical for a cost‐effective and environment‐friendly conversion of cellulosic biomass. However, developing a strategy for achieving a high mass‐transfer rate and good separation efficiency between an insoluble cellulose substrate and cellulase remains difficult. Instead of the traditional method, a single‐enzyme molecular modification method is used in this study. To modify cellulase and provide it with a temperature–pH dual responsive property, systemized poly(acrylic‐acrylonitrile) (PAA–PAN) molecular arms are used. The modified cellulase can reversibly transform between liquid and solid phases. In the liquid phase, the modified cellulase can adjust its active center, increasing its hydrolysis efficiency and separation efficiency. Cellulase and glucose products can be easily separated in the solid phase, allowing the reuse of cellulase. The results show that the modified cellulase's hydrolysis efficiency is comparable to that of free cellulase and that the modified enzyme preserves more than 60% of its initial activity after 15 batches of efficient hydrolysis. Thus, the proposed modification route considerably lowers the cost of cellulose enzymatic hydrolysis.
Dynamic changes in liver volume calculated using a three‐dimensional visualisation system after microwave ablation of hepatocellular carcinomas
Authors: Dong Linan , Cheng Zhigang , Liu Fangyi , Yu Xiaoling , Han Zhiyu , Luo Yanchun , Xu Hongli , Chen Rendong , Huang Chongfei , Yu Jie , Liang Ping 
Published: April 2022

AbstractObjectivesTo investigate the changes in liver volume and function after microwave ablation (MWA) of hepatocellular carcinomas (HCCs).Materials and MethodsWe retrospectively analysed 76 patients with 106 nodules who underwent MWA for HCCs ≤5 cm between January 2015 and September 2017. Liver and ablation volumes were calculated using a three‐dimensional visualisation system on MRI. Multiple regression analysis was used to estimate the association between the ablation volume and liver volume changes. Deformable image registration (DIR) was performed to confirm the influence of liver volume changes on curative effect evaluation after ablation.ResultsThe initial liver and tumour volumes were 1262.1 ± 259.91 cm3 (range: 864.9–1966.8) and 2.5 cm3 (interquartile range [IQR]: 1.3–8.8), respectively. Compared to the initial liver volumes, the entire live volume (ELV) increased by 10.1% ± 8.93% (range: −4.9% to 46.68%) on the 3rd day after ablation. Subsequently, it recovered to initial level at the 3rd month and maintained its level during the 1‐year follow‐up. The median total ablation volume was 34.9 cm3 (IQR: 20.4–65.4) on the 3rd day after ablation, which decreased by 71.2% (IQR: 57.4%–78.1%) 1 year after ablation. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (T‐Bil) peaked within 3 days after MWA and recovered to normal within 1 month. The ablation volume proportion of the ELV was an independent risk factor for the increase in the ELV and AST, ALT and T‐Bil levels within 3 days after ablation. When DIR was conducted to fuse ablation zone and tumour, the reshaped tumour volumes were enlarged by 40% because of the increase in ELV.ConclusionsMWA of HCCs based on the Milan criteria could induce temporary increases in ELV and RLV within 3 days after ablation, but both parameters recovered to initial levels 3 months after ablation. This indicates that MWA of early‐stage HCCs would not lead to liver volume loss and could potentially protect liver function. The liver cannot be treated as an incompressible organ after ablation, and the appropriate deformation constraint should be designed for DIR to evaluate ablation margin accurately.
Glioma grading prediction using multiparametric magnetic resonance imaging‐based radiomics combined with proton magnetic resonance spectroscopy and diffusion tensor imaging
Authors: Lin Kun , Cidan Wangjiu , Qi Ying , Wang Xiaoming 
Published: April 2022

AbstractPurposeTo evaluate the efficacy of three‐dimensional (3D) segmentation‐based radiomics analysis of multiparametric MRI combined with proton magnetic resonance spectroscopy (1H‐MRS) and diffusion tensor imaging (DTI) in glioma grading.MethodA total of 100 patients with histologically confirmed gliomas (grade II–IV) were examined using conventional MRI, 1H‐MRS, and DTI. Tumor segmentations of T1‐weighted imaging (T1WI), contrast‐enhanced T1WI (T1WI+C), T2‐weighted imaging (T2WI), apparent diffusion coefficient (ADC) mapping, and fractional anisotropy (FA) mapping were performed. In total, 396 radiomics features were extracted and reduced using basic tests and least absolute shrinkage and selection operator (LASSO) regression. The selected features of each sequence were combined, and logistic regression with ten‐fold cross‐validation was applied to develop the grading model. Sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC) were compared. The model developed from the training set was applied to the test set to measure accuracy. One optimal grading quantitative parameter was selected for each 1H‐MRS and DTI analysis. A radiomics nomogram model including radiomics signature, quantitative parameters, and clinical features was developed.ResultsT1WI+C exhibited the highest grading efficacy among single sequences (AUC, 0.92; sensitivity, 0.89; specificity, 0.85), but the efficacy of the combined model was higher (AUC, 0.97; sensitivity, 0.94; specificity, 0.91). The AUCs of all models exhibited high accuracy, and no significant differences were observed in AUCs between the training and test sets. The visualized nomogram was developed based on the combined radiomics signature and choline (Cho)/N‐acetyl aspartate (NAA) from 1H‐MRS.ConclusionMultiparametric MRI can be used to predict the pathological grading of high‐grade gliomas (HGGs) and low‐grade gliomas (LGGs) by combining radiomics features with quantitative parameters. The visualized nomogram may provide an intuitive assessment tool in clinical practice.Clinical trial registrationThis trial was not registered, as it was a retrospective study and was approved by the local institutional review board.
A review of high‐velocity impact on fiber‐reinforced textile composites: Potential for aero engine applications
Authors: Li Yinghong , Chen Xuefeng , Zhou Jin , Liu Xiaochuan , Zhang Di , Du Feiping , He Weifeng , Jia Pu , Liu Haibao 
Published: April 2022

AbstractConsiderable research has indicated that fiber‐reinforced textile composites are significantly beneficial to the aerospace industry, especially aero engines, due to their high specific strength, specific stiffness, corrosion resistance, and fatigue resistance. However, damage caused by high‐velocity impacts is a critical limitation factor in a wide range of applications. This paper presents an overview of the development, material characterizations, and applications of fiber‐reinforced textile composites for aero engines. These textile composites are classified into four categories including two‐dimensional (2D) woven composites, 2D braided composites, 3D woven composites, and 3D braided composites. The complex damage mechanisms of these composite materials due to high‐velocity impacts are discussed in detail as well.
Relationship between autistic traits and social functioning in healthy individuals
Authors: Demizu Yuria , Matsumoto Junya , Yasuda Yuka , Ito Satsuki , Miura Kenichiro , Yamamori Hidenaga , Fujimoto Michiko , Hasegawa Naomi , Ishimaru Keiichiro , Hashimoto Ryota 
Published: April 2022

AbstractAimSocial functioning is influenced by various factors. Autistic traits could be one of the factors that affect social functioning.MethodsIn the present study, the relationship between autistic traits and social functioning among 755 healthy individuals was analyzed. Autistic traits were assessed with the autism‐spectrum quotient. Social functioning was assessed by the social functioning scale and the social activity assessment.ResultsThe Autism‐Spectrum Quotient total score was significantly negatively correlated with the social functioning scale total and all subscales of the social functioning scale. All subscales of the Autism‐Spectrum Quotient except attention to detail were significantly negatively correlated with the social functioning scale total score. However, the Autism‐Spectrum Quotient was not correlated with the social activity assessment, which indicates labor functioning.ConclusionAutistic traits of healthy individuals had a negative impact on situations in real life through social functioning for daily life‐sustaining. The effect was not enough to affect labor functioning as indicated by working hours in healthy individuals. These findings should also be examined in individuals with autism spectrum disorder in future studies.