bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐read genome sequencing resolves a complex 13q structural variant associated with syndromic anophthalmia
Authors: Boerkoel Pierre K. , Dixon Katherine , Fitzsimons Carrie , Shen Yaoqing , Huynh Stephanie , Schlade‐Bartusiak Kamilla , Culibrk Luka , Chan Simon , Boerkoel Cornelius F. , Jones Steven J. M. , Chin Hui‐Lin 
Published: February 2022

AbstractMicrophthalmia, anophthalmia, and coloboma (MAC) are a heterogeneous spectrum of anomalous eye development and degeneration with genetic and environmental etiologies. Structural and copy number variants of chromosome 13 have been implicated in MAC; however, the specific loci involved in disease pathogenesis have not been well‐defined. Herein we report a newborn with syndromic degenerative anophthalmia and a complex de novo rearrangement of chromosome 13q. Long‐read genome sequencing improved the resolution and clinical interpretation of a duplication–triplication/inversion–duplication (DUP‐TRP/INV‐DUP) and terminal deletion. Sequence features at the breakpoint junctions suggested microhomology‐mediated break‐induced replication (MMBIR) of the maternal chromosome as the origin. Comparing this rearrangement to previously reported copy number alterations in 13q, we refine a putative dosage‐sensitive critical region for MAC that might provide new insights into its molecular etiology.
Multifunctional Wearable Silver Nanowire Decorated Leather Nanocomposites for Joule Heating, Electromagnetic Interference Shielding and Piezoresistive Sensing
Authors: Ma Zhonglei , Xiang Xiaolian , Shao Liang , Zhang Yali , Gu Junwei 
Published: February 2022

AbstractMultifunctional wearable electronic devices based on natural materials are highly desirable for versatile applications of energy conversion, electronic skin and artificial intelligence. Herein, multifunctional wearable silver nanowire decorated leather (AgNW/leather) nanocomposites with hierarchical structures for integrated visual Joule heating, electromagnetic interference (EMI) shielding and piezoresistive sensing are fabricated via the facile vacuum‐assisted filtration process. The AgNWs penetrate the micro‐nanoporous structures in the corium side of leather constructing highly‐efficient conductive networks. The resultant flexible and mechanically strong AgNW/leather nanocomposites exhibit extremely low sheet resistance of 0.8 Ω/sq, superior visual Joule heating temperatures up to 108 °C at low supplied voltage of 2.0 V due to efficient energy conversion, excellent EMI shielding effectiveness (EMI SE) of ≈55 dB and outstanding piezoresistive sensing ability in human motion detection. This work demonstrates the fabrication of multifunctional AgNW/leather nanocomposites for next‐generation wearable electronic devices in energy conversion, electronic skin and artificial intelligence, etc.
Enhanced ultraviolet‐protectivetextiles based on reduced graphene oxide‐silver nanocomposites on polyethylene terephthalate usingultrasonic‐assisted in‐situthermal synthesis
Authors: Babaahmadi Vahid , Abuzade Ramazan Ali , Montazer Majid 
Published: February 2022

AbstractThe present research develops a novel in‐situ synthesis method to produce a high performance nanocomposite coating on polyethylene terephthalate (PET) fabric as an enhanced UV‐protective textile. Reduced graphene oxide‐silver (rGO‐Ag) multi‐layer nanocomposite was in‐situ synthesized on the PET fabric through the direct redox reaction between the Ag+ions and GO sheets by using ultrasonic and thermal treatment. The X‐ray diffraction and field emission scanning electron microscope confirmed that the well‐synthesized Ag nanoparticles (AgNPs) loaded on PET fabric in presence of the GO sheets by using ultrasonic waves without reducing and capping agents. In this research, GO sheets were used as reducing and capping agents along with the ultrasonic treatment at low temperature condition. The final average size of the synthesized AgNPs in solution, on the PET surface and in the freestanding film is lower than 100 nm. The ultraviolet protection factor (UPF) of the PET fabric incorporating multi‐layer rGO‐Ag nanocomposite as a UV blocking system could reach to 6145.66, up to the 183‐fold higher than uncoated PET fabric (UPF 33.63). In addition, the final fabric demonstrates a good air permeability and antibacterial properties due to the effective coating of rGO‐Ag nanocomposite on PET surface.
Photoinduced adsorption of Cr(VI) ions in nano‐zinc oxide and nano‐zinc oxide/polypyrrole composite
Authors: Ramos‐Hernández Luis E. , Pérez‐Aguilar Nancy V. , Ovando‐Medina Victor M. , Oyervides‐Muñoz Ernesto , Arcibar‐Orozco Javier A. 
Published: February 2022

AbstractZinc oxide‐polypyrrole composites (ZnO‐PPY) are novel materials that have attracted significant attention in recent years. These materials have the potential to remove hazardous pollutants from water effectively. Here, we explore facile synthesis, characterization, and adsorption capacity of hexavalent chromium anions, by nano‐ZnO and nano‐ZnO‐PPY composite. Cold precipitation of ZnO using sodium dodecyl sulfate as an additive prevents nanoparticle growth, which permits the composite preparation with PPY. The results demonstrated that the ZnO‐PPY structure was different than ZnO, more amorphous, less porous, and with a different morphology. New Fourier transform infrared spectroscopy vibrations observed in ZnO‐PPY hinted an interaction with ZnO, leading to a more acidic surface. This information could point to the composite formation driven by interactions between oxygen groups and pyrrole nitrogen. Both materials performed better under light, indicating a photoinduced adsorption phenomenon favored by oxygen vacancies. The new composite demonstrated a reduced adsorption capacity compared to ZnO at neutral and slightly acidic pHs due to electrostatic repulsion of the negatively charged surface and Cr(VI) anions. At alkaline pHs, the pyrrolic nitrogen's is able to interact with partially charged Cr‐complex and to carry out a ligand interchange even in a not favorable charge environment. The ZnO‐PPY composite, outperformed the zinc oxide capacity.
Feeling for food: Can rostro‐mental hair arrays sense hydrodynamic cues for foraging North Atlantic right whales?
Authors: Murphy Christin T. , Marx Marilyn , Martin William N. , Jiang Houshuo , Lapseritis Joy M. , French Alison N. , Simmons Nancy B. , Moore Michael J. 
Published: February 2022

AbstractNorth Atlantic right whales (NARWs; Eubalaena glacialis) possess an arrangement of fine hairs on the rostrum and chin that may be used for hydrodynamic sensing during feeding. These hairs occur across mysticete species and are known to possess adequate innervation in the subdermal follicle to support their consideration as sensory hairs (vibrissae). However, the small size of the hair structure with respect to the enormous scale of the animal's body has caused doubts regarding their utility and prompted speculation that the hairs may be vestigial or minimally functional. Here we show that NARW hairs occur in abundance on the leading surface of the head in a unique and characteristic arrangement. We consider the sensory hairs in context of the fluid environment in which this species forages and argue that the size of the hair is scaled to the size of the animal's small planktonic prey, thus suggesting that the hairs play an important role in the sensory ecology of these animals.
A retrieval model family based on the probability ranking principle for ad hoc retrieval
Authors: Dang Edward Kai Fung , Luk Robert Wing Pong , Allan James 
Published: February 2022

AbstractMany successful retrieval models are derived based on or conform to the probability ranking principle (PRP). We present a new derivation of a document ranking function given by the probability of relevance of a document, conforming to the PRP. Our formulation yields a family of retrieval models, called probabilistic binary relevance (PBR) models, with various instantiations obtained by different probability estimations. By extensive experiments on a range of TREC collections, improvement of the PBR models over some established baselines with statistical significance is observed, especially in the large Clueweb09 Cat‐B collection.
The price‐leverage covariation as a measure of the response of the leverage effect to price and volatility changes
Authors: Toscano Giacomo 
Published: February 2022

AbstractWe study the sensitivity of the leverage effect to changes of the volatility and the price, showing the existence of an analytical link between the latter and the price‐leverage covariation in settings with, respectively, stochastic and level‐dependent volatility. From the financial standpoint, the results we obtain allow for the interpretation of the price‐leverage covariation as a gauge of the responsiveness of the leverage effect to price and volatility changes. The empirical study of S&P500 high‐frequency prices over the period March 2018–April 2018, carried out by means of nonparametric Fourier estimators, supports this interpretation of the role of the price‐leverage covariation.
In vitro wound healing properties, antioxidant activities, HPLC–ESI–MS/MS profile and phytoconstituents of the stem aqueous methanolic extract of Dracaena reflexa Lam
Authors: Raslan Mona A. , Afifi Ahmed H. 
Published: February 2022

AbstractColumn chromatography of the stem aqueous methanolic extract of Dracaena reflexa Lam. (DRSE) led to the isolation of five flavonoids, one phenolic glycoside, one triterpenoid and two steroidal saponins. Furthermore, 44 compounds were tentatively identified in the phytoconstituent profile of DRSE using HPLC–ESI–MS/MS. The antioxidant activity of DRSE was evaluated. In a DPPH radical scavenging assay, DRSE exhibited an IC50 value of 311.6 ± 10.10 μg/ml compared with the IC50 value of the standard Trolox (24.42 ± 0.87 μg/ml). The antioxidant activities of DRSE using ABTS assay and ferric reducing antioxidant power assay were 326.63 μm Trolox equivalents/mg extract and 208.67 μm Trolox equivalents/mg extract, respectively. The wound‐healing activity of DRSE was studied by the scratch assay using Human Skin Fibroblast cells. After 24 h DRSE (at 10 and 20 μg/ml) decreased the wound width to 0.55 ± 0.37 and 0.47 ± 0.55 mm, respectively, compared with the wound width in the control cells (0.77 ± 0.17 mm). This result suggested that DRSE improved the wound‐healing process by inducing the migration of fibroblasts. Moreover, a docking study was performed to evaluate the binding affinity of the identified phytoconstituents toward GSK‐3β relative to the co‐crystalized inhibitor and curcumin with the possible involvement of this pathway in the wound‐healing activity of the extract.
Applied Geometry Optimization of an Innovative 3D‐Printed Wet‐Scrubber Nozzle with a Lattice Boltzmann Method
Authors: Reinke Felix , Hafen Nicolas , Haussmann Marc , Novosel Michael , Krause Mathias J. , Dittler Achim 
Published: February 2022

AbstractIn contrast to conventional dry separators, new types of wet scrubbers with innovative nozzle geometries are capable of separating submicron particles with comparatively low pressure drop. As those geometries can easily be adapted using 3D‐printing manufacturing, an applied geometry optimization can lead to a fast and cost‐efficient product development cycle. In this study, the lattice Boltzmann method is used to optimize the pressure drop associated with a novel nozzle design. Simulated pressure drop data are validated with experimentally determined ones. By replacing originally installed ellipsoid‐shaped bluff bodies with foil‐shaped structures according to the 4‐digit NACA‐series, an optimization approach regarding the resulting pressure drop is described.
Echocardiographically defined haemodynamic categorization predicts prognosis in ambulatory heart failure patients treated with sacubitril/valsartan
Authors: Dini Frank L. , Carluccio Erberto , Bitto Roberto , Ciccarelli Michele , Correale Michele , D'Agostino Andreina , Dattilo Giuseppe , Ferretti Marco , Grelli Arianna , Guida Stefania , Jacoangeli Francesca , Lupi Laura , Luschi Lorenzo , Masarone Daniele , Mercurio Valentina , Pacileo Giuseppe , Pugliese Nicola Riccardo , Rispoli Antonella , Scelsi Laura , Tocchetti Carlo Gabriele , Brunetti Natale Daniele , Palazzuoli Alberto , Piepoli Massimo , Nodari Savina , Ambrosio Giuseppe ,   Working Group on Heart Failure of the Italian Society of Cardiology
Published: February 2022

AbstractAimEcho‐derived haemodynamic classification, based on forward‐flow and left ventricular (LV) filling pressure (LVFP) correlates, has been proposed to phenotype patients with heart failure and reduced ejection fraction (HFrEF). To assess the prognostic relevance of baseline echocardiographically defined haemodynamic profile in ambulatory HFrEF patients before starting sacubitril/valsartan.Methods and resultsIn our multicentre, open‐label study, HFrEF outpatients were classified into 4 groups according to the combination of forward flow (cardiac index; CI:< or ≥2.0 L/min/m2) and early transmitral Doppler velocity/early diastolic annular velocity ratio (E/e′: ≥ or <15): Profile‐A: normal‐flow, normal‐pressure; Profile‐B: low‐flow, normal‐pressure; Profile‐C: normal‐flow, high‐pressure; Profile‐D: low‐flow, high‐pressure. Patients were started on sacubitril/valsartan and followed‐up for 12.3 months (median). Rates of the composite of death/HF‐hospitalization were assessed by multivariable Cox proportional‐hazards models. Twelve sites enrolled 727 patients (64 ± 12 year old; LVEF: 29.8 ± 6.2%). Profile‐D had more comorbidities and worse renal and LV function. Target dose of sacubitril/valsartan (97/103 mg BID) was more likely reached in Profile‐A (34%) than other profiles (B: 32%, C: 24%, D: 28%, P < 0.001). Event‐rate (per 100 patients per year) progressively increased from Profile‐A to Profile‐D (12.0%, 16.4%, 22.9%, and 35.2%, respectively, P < 0.0001). By covariate‐adjusted Cox model, profiles with low forward‐flow (B and D) remained associated with poor outcome (P < 0.01). Adding this categorization to MAGGIC‐score and natriuretic peptides, provided significant continuous net reclassification improvement (0.329; P < 0.001). Intermediate and high‐dose sacubitril/valsartan reduced the event's risk independently of haemodynamic profile.ConclusionsEchocardiographically‐derived haemodynamic classification identifies ambulatory HFrEF patients with different risk profiles. In real‐world HFrEF outpatients, sacubitril/valsartan is effective in improving outcome across different haemodynamic profiles.
Lithium‐Ion Mobility in Layered Oxide Li2(La0.75Li0.25)(Ta1.5Ti0.5)O7 Containing Lithium on both Intra and Inter‐Stack Positions
Authors: Fanah Selorm Joy , Ramezanipour Farshid 
Published: February 2022

AbstractWith the aid of neutron diffraction and electrochemical impedance spectroscopy, we have demonstrated the effect of the increase in lithium concentration and distribution on Li‐ion conductivity. This has been done through the synthesis of a layered oxide Li2(La0.75Li0.25)(Ta1.5Ti0.5)O7, with the so‐called Ruddlesden‐Popper type structure, where bilayer stacks of (Ta/Ti)O6 octahedra are separated by lithium ions, located in inter‐stack spaces. There are also intra‐stack spaces that are occupied by a mixture of La and Li, as confirmed by neutron diffraction. The distribution of lithium over both inter‐ and intra‐stack positions leads to the enhancement of Li‐ion conductivity in Li2(La0.75Li0.25)(Ta1.5Ti0.5)O7 compared to Li2La(TaTi)O7, which has a lower concentration of lithium ions, located only in inter‐stack spaces. The analyses of real and imaginary components of electrochemical impedance data confirm the enhanced mobility of ions in Li2(La0.75Li0.25)(Ta1.5Ti0.5)O7. While the Li‐ion conductivity needs further improvement for practical applications, the success of the strategy implemented in this work offers a useful methodology for the design of layered ionic conductors.
Study on dynamic changes of microbial community and lignocellulose transformation mechanism during green waste composting
Authors: Zhang Yushan , Chen Mengting , Guo Jingyi , Liu Ning , Yi Weiyi , Yuan Zhongtai , Zeng Lifan 
Published: February 2022

AbstractThere are few reports on the material transformation and dominant microorganisms in the process of greening waste (GW) composting. In this study, the target microbial community succession and material transformation were studied in GW composting by using MiSeq sequencing and PICRUSt tools. The results showed that the composting process could be divided into four phases. Each phase of the composting appeared in turn and was unable to jump. In the calefactive phase, microorganisms decompose small molecular organics such as FA to accelerate the arrival of the thermophilic phase. In the thermophilic phase, thermophilic microorganisms decompose HA and lignocellulose to produce FA. While in the cooling phase, microorganisms degrade HA and FA for growth and reproduction. In the maturation phase, microorganisms synthesize humus using FA, amino acid and lignin nuclei as precursors. In the four phases of the composting, different representative genera of bacteria and fungi were detected. Streptomyces, Myceliophthora and Aspergillus, maintained high abundance in all phases of the compost. Correlation analysis indicated that bacteria, actinomycetes and fungi had synergistic effect on the degradation of lignocellulose. Therefore, it can accelerate the compost process by maintaining the thermophilic phase and adding a certain amount of FA in the maturation phase.
Impact of the Three Gorges Dam on riverbed scour and siltation of the middle reaches of the Yangtze River
Authors: Yang Yunping , Zheng Jinhai , Zhang Huaqing , Chai Yuanfang , Zhu Yude , Wang Chenyang 
Published: February 2022

AbstractThis study investigated the influence of the Three Gorges Dam (TGD) on the evolution of nearby channels in the Yangtze River (Changjiang River) system in order to better understand the environmental impact of large‐scale reservoir operations. From 2003 to 2017, the amounts of runoff and sediment transport in the Yangtze River were reduced by 3.3–14.5% and 67.8–92.7%, respectively, relative to 1955–2002 before the TGD was operational. Topographic measurements of the middle reaches (Yichang to Hukou) of the Yangtze River were analyzed from 1975 to 2017, during which time the cumulative erosion of the flood channel was 22.78 × 108 m3, and the dry channel accounted for 90.3% of the erosion. Following commissioning of the TGD, the scouring intensity of the sandy gravel section near the dam initially increased then decreased, whereas the scouring intensity of sandy sections away from the dam continued to increase. Beaches on convex banks of curved sections were scoured, and deep channels on concave banks became silted. In braided sections, the braids tended to shrink, and the diversion ratio of the main branch during dry seasons reduced, resulting in frequent branch alternation. Compared to changes in the downstream river channels of other large reservoirs worldwide, scouring from the TGD is extensive. The findings of this study are significant for river channel regulation and waterway planning in the Yangtze River and worldwide.
Introspection confidence predicts EEG decoding of self‐generated thoughts and meta‐awareness
Authors: Polychroni Naya , Herrojo Ruiz Maria , Terhune Devin B. 
Published: February 2022

AbstractThe neurophysiological bases of mind wandering (MW)—an experiential state wherein attention is disengaged from the external environment in favour of internal thoughts—and state meta‐awareness are poorly understood. In parallel, the relationship between introspection confidence in experiential state judgements and neural representations remains unclear. Here, we recorded EEG while participants completed a listening task within which they made experiential state judgements and rated their confidence. Alpha power was reliably greater during MW episodes, with unaware MW further associated with greater delta and theta power. Multivariate pattern classification analysis revealed that MW and meta‐awareness can be decoded from the distribution of power in these three frequency bands. Critically, we show that individual decoding accuracies positively correlate with introspection confidence. Our results reaffirm the role of alpha oscillations in MW, implicate lower frequencies in meta‐awareness, and are consistent with the proposal that introspection confidence indexes neurophysiological discriminability of representational states.
Scoping review – What do we know about Aboriginal peoples’ use of dose administration aids?
Authors: Walke Emma , Barclay Lesley , Longman Jo 
Published: February 2022

AbstractIssue addressedThis paper aims to report findings of a scoping review which mapped and summarised available literature regarding Aboriginal peoples’ use of Dose Administration Aids (DAAs) for improved medication management.Aboriginal and Torres Strait Islander peoples have higher rates of chronic disease than other Australians. This leads to increased numbers of prescribed medications and complex medication taking regimens. The Australian Government and Pharmacy Bodies provide programs for Aboriginal peoples with chronic conditions, including programs supporting access to DAAs to improve medication adherence.MethodsThe search strings used included three key concepts: Indigeneity; DAAs and outcomes. PubMed, Medline via Ovid and the grey literature were searched.ResultsAfter removal of duplicates, 426 papers were screened by title and abstract for inclusion. A further 407 papers were then excluded leaving a total of nineteen papers included in the review. Only three of these papers included all three concepts in the search criteria, and none of these were empirical studies.ConclusionThe lack of studies found in this review support the requirement for empirical research regarding the effects of DAAs on medication taking behaviours of Aboriginal people, and the programs that provide them.So What?The Australian Government funds programs that provides access to DAAs as a method of improving medication taking behaviours. But what do we really know about DAAs and if or how they assist in this goal? This review scopes out what is known, in order to direct studies that will answer this question.
Legacy‐micropollutant contamination levels in major river basins based on findings from the Rhône Sediment Observatory
Authors: Delile Hugo , Dendievel André‐Marie , Yari Anice , Masson Matthieu , Miège Cécile , Mourier Brice , Coquery Marina 
Published: February 2022

AbstractFor more than half a century, chemical contamination has progressively spread to all the large river basins. Large river outlets integrate multiple anthropogenic pressures in watersheds, making them the largest source of sediment‐bound contaminants to continental shelf areas. However, comparing particulate micropollutant contaminations between the large river basins is a challenging task, especially due to the scarcity of long‐term river monitoring programs. Here we address this issue, with a focus on legacy particulate micropollutants (polychlorobiphenyls [PCBi], polycyclic aromatic hydrocarbons [PAHs] and trace metal elements [TME]) yields. For this purpose, we employed a bottom‐up multiscale approach to chemical contamination in river basins that takes micropollutant yields measured in the Rhône River sub‐basins (France) as a benchmark of other large river basins. Data on the Rhône River basin came from a unique 10‐year‐long monitoring program within the Rhône Sediment Observatory (OSR), and were compared to data gathered on 18 major worldwide river outlets. The Rhône River basin is far cleaner now than a few decades ago, likely due to environmental regulations. At a wider spatial scale, our results depict an overall contamination gradient splitting the most heavily contaminated river basins, located in developing and industrializing low‐to‐middle‐income countries, from the least contaminated rivers located in developed high‐income countries. We argue that chemical contamination levels of large river basins depend on their stage of economic development.