bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of Wikipedia in the dissemination of new knowledge: Analysis of the entry «desinformación» as a changeable concept
Authors: Pérez-Escolar Marta , Herrero-Diz Paula 
Published: April 2022

The main goal of Wikipedia’s founders, Jimmy Wales and Larry Sanger, was to create a collaborative encyclopaedia driven by the users of the internet who, on a nonprofit basis, would compile and share all human wisdom and knowledge. In times of crisis, such as the coronavirus pandemic, Wikipedia has emerged as a reference point for users around the world. In this vein, Wikipedia once again highlighted its cultural role in the production of available knowledge in the face of new knowledge.
Therefore, the main objective of this study is to analyse the specific entry of desinformación –disinformation in English– in the Spanish version of Wikipedia, given the importance that this concept has acquired during the coronavirus crisis and given the need to disseminate a homogeneous definition of this term. For that purpose, we have applied the content analysis method to a textual case, that is, to the disinformation entry in Wikipedia. The main results show that the basic characteristics of the Spanish entry of desinformación on Wikipedia are not the suitable ones to inform users or readers of the real meaning of this concept. Furthermore, the content of the Wikipedia disinformation entry is incomplete, disjointed and of dubious reliability. Therefore, this research advocates the creation of a homogeneous definition that permeates the common imaginary and that is the result of a combination of experts’ opinions and the definitions proposed by institutions, governments, media and organizations.
Mecanismos Epigenéticos no Surgimento do Câncer: uma Revisão Bibliográfica
Authors: Batista Santos Inara Thaís , Queiroz de Mello Padilha Itácio 
Published: April 2022

Os fenômenos mutacionais em regiões gênicas responsáveis pelo ciclo celular e reparo aos danos de DNA estão intimamente relacionados com a formação do câncer. Além disso, as alterações epigenéticas contribuem, significativamente, para o surgimento de neoplasias, e envolvem metilação do DNA, as modificações de histonas e o imprinting genômico. Este trabalho tem como objetivo verificar na literatura como os mecanismos epigenéticos estão relacionados com o surgimento de diferentes tipos de câncer. Foi realizada uma revisão integrativa, a partir de pesquisas de artigos científicos publicados no período de 2017 a 2021, nas plataformas Scielo e PubMed com os descritores: “epigenética”, “câncer”, “susceptibilidade” e “hipermetilação”, disponíveis nos idiomas português, inglês e espanhol, no intervalo de tempo dos últimos cinco anos, e que abordasse a temática do estudo. Os resultados obtidos a partir da revisão bibliográfica demonstram claramente que grandes mudanças na metilação do DNA em regiões gênicas chave e ilhas CpG estão relacionados com o surgimento do câncer. Nos últimos anos, as pesquisas biomédicas têm demonstrado o potencial da metilação anormal do DNA para uso como biomarcadores do câncer. De fato, a compreensão do papel dos mecanismos epigenéticos no desenvolvimento do câncer permite que sejam criados métodos de diagnóstico e tratamentos mais eficazes.

Palavras-chave: Epigenética. Câncer. Metilação. Prognóstico.

Abstract
Mutational phenomena in gene regions responsible for cell cycle and DNA damage repair are closely related to cancer formation. Furthermore, epigenetic alterations significantly contribute to the emergence of neoplastic cells due to DNA methylation, histone modifications, and genomic imprinting. This work aims to verify in the literature how epigenetic mechanisms are related to the emergence of different types of cancer. An integrative review was carried out based on research of scientific articles published from 2017 to 2021, on the Scielo and PubMed platforms with the descriptors: "epigenetics", "cancer", "susceptibility" and "hypermethylation", available in Portuguese, English, and Spanish, within the period of the last five years. The results obtained from the literature review demonstrate that large changes in DNA methylation in key gene regions and CpG islands are related to the cancer emergence. In recent years, biomedical research has demonstrated the potential for abnormal DNA methylation for use as cancer biomarkers. Understanding the role of epigenetic mechanisms in the development of cancer allows for the creation of more effective diagnostic methods and treatments.

Keywords: Epigenetics. Cancer. Methylation. Prognosis.
A novel surgical method for total nail ablation: Use of triple flap technique
Authors: Aksoy Berna 
Published: April 2022

<p>Total nail ablation for the treatment of onychodystrophies can be performed by using chemicals, surgical resection or laser ablation of nail matrix.<strong> </strong>A female patient with bilateral severe onychodystrophy as a result of inadvertent previous nail surgeries was treated surgically. Proximal complete nail matrix resection and distal 10 mm wide transverse strip partial nail bed resection were performed. A 5 mm wide transverse strip of nail bed was left intact proximally. Proximal nail matrix defect was closed by using the skin of proximal nail fold. The distal nail bed defect was reconstructed by using triple flap technique which was composed of a main central advancement flap containing ventral toe skin and two side flaps containing nail fold skin. The patient healed without any problem and her nail problem was treated successfully. The cosmetic appearance of her first toes was acceptable. Surgical nail ablation followed by volar skin coverage of dorsal surface of the distal phalanx bone by using triple flap technique is an effective surgical treatment method for the correction of advanced nail plate deformities requiring total nail ablation. </p>
A randomized, double-blind, comparative study for efficacy assessment of two hyaluronic acid nasolabial fillers
Authors: Ahmad Nasrollahi Saman , Nassiri Kashani Mansour , Yazdanparast Taraneh , Ameri Setareh , Firooz Alireza 
Published: April 2022

<p class="Default">Hyaluronic acid fillers are considered safe for use in cosmetics as described in the safety assessment. This study was aimed to assess and compare the efficacy and safety of two hyaluronic acid (HA) fillers on mild nasolabial folds. Ten women aged 30-50 years with mild nasolabial folds participated for injection of A and B gels into right or left nasolabial folds. The volume and surface of nasolabial folds were measured by CSI software and the density and thickness of dermis assessed by skin ultrasonography before and 2, 12, and 24 weeks after injection. The data were analyzed using SPSS software version 20, and p-value &lt;0.05 were considered as significant. Global assessment showed over 50% improvement in patients injected with both gel A and B. At 2 weeks after injecting gel A the volume and surface of wrinkles decreased significantly. In the side injected with gel B, this reduction was significant at 2 and 12 weeks after injection. In addition, 24 weeks after injection of both gels the dermis echo-density increased and the dermis thickness decreased. This study indicated the significant positive filling effect of both HA fillers in decreasing the clinical signs of wrinkles at nasolabial folds. Comparing both fillers, there were not any statistically significant differences in any of measurements, but the persistence of gel B to improve the wrinkle appearance was slightly better than gel A. </p>
Passing by Layers of Memory
Authors: Burghardt Anja 
Published: April 2022

The paper discusses the dimensions, genres and mediality of collective memory in Mariusz Wilk’s reportage on the Solovetsky Islands. As the authoress argues, on the one hand, his reports reflect a broad variety of different media, where the text itself also appears as a medium of memory. On the other hand, Wilk draws attention to the sites of memory on the Solovetsky Islands. For those, different concepts from memory studies help deepen our understanding of both the layers of memory on the islands and of those in Wilk’s text.
Sarmacki Odyseusz. Postać Jana Łaskiego w epicedium Andrzeja Trzecieskiego
Authors: Ryczek Wojciech 
Published: April 2022

Artykuł stanowi propozycję interpretacji wybranych motywów z epicedium upamiętniającego postać i działalność Jana Łaskiego Młodszego (zmarł 8 I 1560 roku w Pińczowie), humanisty i wybitnego reformatora religijnego (Ioannis a Lasco viri clarissimi epicedion). Andrzej Trzecieski (Tricesius, ok. 1525 – po 1584) był autorem wielu łacińskich epigramatów, elegii, epitafiów, epicediów i utworów pochwalnych.
W elegii żałobnej dla Łaskiego twórczo przekształcił on strukturę antycznego epicedium, obejmującą tradycyjne elementy comploratio (opłakiwania), laudatio (pochwały zmarłego) i consolatio (pocieszenia). Dołożył wszelkich starań, aby ukazać zmarłego reformatora jako męża słynącego z pobożności, czcigodnego starca jaśniejącego licznymi cnotami, a przede wszystkim nowego proroka zapowiadającego odrodzenie Kościoła. W tym kontekście Trzecieski przywołuje trzy przykłady wybitnych mówców: św. Jana Chryzostoma (Złotoustego), galijskiego Herkulesa i „wielce obrotnego” (politropicznego) Odyseusza.
Siedem „grzechów głównych” popełnianych w badaniach nad przemocą antyżydowską
Authors: Markowski Artur 
Published: April 2022

Artykuł wyznacza obszary zaniedbań i błędów metodologicznych, jakie najczęściej popełniane są w studiach nad przemocą antyżydowską. Wyróżnionych zostało siedem takich stref. Pierwsza dotyczy celu badań, druga to kwestia poszukiwania uniwersalnej definicji, trzecia zamyka się w uznawaniu przemocy antyżydowskiej za fenomen. Czwarta strefa to zagadnienie kontekstualizacji badań, piąta to uprzedmiotowienie „obiektu” badań, szósta kontrast między poziomami analizy, a siódmą określam jako problemy koherentności źródeł i narzędzi badawczych.
Tendances des inégalités socioéconomiques et spatiales de la santé des enfants de moins de 5ans au Niger
Authors: Adamou Djibo Habila , Alexandre Schouame Magloire , Kone Hamidou 
Published: April 2022

Objectif : Les indicateurs de malnutrition et de mortalité infanto-juvénile sont en constante baisse au Niger, au fil des différentes Enquêtes Démographiques et de Santé. Toutefois, certains groupes sociaux restent à la marge de cette amélioration. Cet article analyse l’impact des disparités géographiques et socioéconomiques des parents sur la santé des enfants au Niger.
Source de données : Elles sont issues de la série d’enquêtes démographiques et de santé à indicateurs multiples de 2006 et de 2012 au Niger. Les EDS sont des enquêtes populationnelles transversales organisées par le programme ‘‘demographic and health surveys’’ dans plus de 100 pays. Les enquêtes de l’année 2006 et de 2012 sont les plus récentes au Niger à ce jour.
Résultats et conclusion : Ainsi, il se dégage au Niger que l’état de santé des enfants dépend de l’existence et de la qualité des « biens sociaux », qui sont étroitement liés au contexte de résidence des parents, tels que les services de santé, les denrées alimentaires et le système éducatif, et donc des régimes sociopolitiques. Ensuite, la santé des enfants dépend des facteurs socioéconomiques des ménages – l’instruction de la mère et les biens sociaux du ménage –, et en particulier de la mère.
Objective: The indicators of malnutrition and infant and child mortality are constantly decreasing in Niger, according to the various Demographic and Health Surveys. However, some social groups remain on the margins of this improvement. This article analyzes the impact of geographic and socioeconomic disparities among parents on child health in Niger.
Data source: The data are from the 2006 and 2012 round of Multiple Indicator Cluster Surveys (MICS) in Niger. The DHS are cross-sectional population surveys organized by the Demographic and Health Surveys program in over 100 countries. The 2006 and 2012 surveys are the most recent in Niger to date.
Results and conclusion: In Niger, the health status of children depends on the existence and quality of "social goods", which are closely linked to the context of residence of the parents, such as health services, food and the education system, and therefore to the socio-political regimes. Second, children's health depends on household socioeconomic factors - the mother's education and the household's social assets - and in particular on the mother.
Incidences des Trajectoires Professionnelles sur l’Entrepreneuriat dans la Ville de Cotonou au Benin
Authors: Tohon Sètongninougbo Hermann Eric , Fakeye Hubert Madjecodoumy 
Published: April 2022

Les entrepreneurs sont confrontés aux problèmes de fonctionnalité de leurs entreprises qui cachent celui de la préparation à la création de l’entreprise et celui de l’organisation des entreprises. Or, la création des entreprises résulte d’une diversité de trajectoires des entrepreneurs. Aussi, l’objectif de cette recherche est-il d’analyser les liens entre les trajectoires professionnelles et la fonctionnalité des entreprises, la préparation à la création et l’organisation des entreprises. Pour ce faire, elle s’appuie sur une approche méthodologique basée sur une recherche quantitative menée auprès de 246 entrepreneurs choisis aléatoirement. L’analyse de dispersion des séquences a permis de mesurer la force des liaisons. Il apparaît que sur les 235 entrepreneurs ayant décrit leurs trajectoires professionnelles, 200 soit 85% des entrepreneurs ont leurs entreprises fonctionnelles tandis que 35 soit 15% n’ont pas leurs entreprises fonctionnelles. De plus, les trajectoires professionnelles ont une incidence statistiquement significative sur la fonctionnalité des entreprises, la préparation à l’entrepreneuriat et l’organisation des entreprises.

Entrepreneurs face the enterprises functionality problems which conceal the enterprises creation preparing problem and the enterprises organizing problem. However, the creation of companies results from a diversity of entrepreneurs trajectories. Therefore, the objective of this research is to analyze the links between professional trajectories and the companies functionality, creation preparation and companies organization. To do this, a methodological approach based on quantitative research is conducted with 246 randomly selected entrepreneurs. The discrepancy analysis of state sequences is made to release the strength of the bonds. It appears that of the 235 entrepreneurs who described their professional trajectories, 200 or 85% of entrepreneurs have their businesses functional while 35 or 15% do not have their businesses functional. In addition, professional trajectories have statistically a significant impact on the enterprises functionality, preparation for entrepreneurship and the enterprises organization.
Traumatisme psychique par types des violences sexuelles chez les adultes et les enfants mineurs dans un contexte post-conflit dans la Province de la Tshopo en République Démocratique du Congo
Authors: Tana André Mavinga , Likongo Marcel Otita , Verelst An , Konan Edouard , Nandindo Chantal 
Published: April 2022

Cet article vise à identifier les symptômes de la détresse psychologique suivant la typologie des violences sexuelles dégagée à partir des entretiens individuels avec des victimes et leurs proches ainsi que des données de la prise en charge médico-psychologique du centre de santé Alwaleed. L’étude inscrite dans le cadre de théorisation ancrée a utilisé comme sources les dossiers et les récits des victimes de violences sexuelles au centre Alwaleed ainsi que l’entretien individuel réalisé à domicile auprès des victimes et de leurs proches. Il a été observé que quelle que soit la situation-type dans laquelle se situe la victime, celle-ci exprime le traumatisme subi sur le plan aussi bien physique, psychologique que comportemental. Le traumatisme subi par les sujets des situations-types II et III provient des réactions de la famille et de la communauté. Le traumatisme dont souffre une victime affecte de la même manière les membres proches de cette victime.

This article aims to identify the symptoms of psychological distress according to the typology of sexual violence identified from individual interviews with victims and their relatives as well as data from the medicalpsychological care of the Alwaleed health center. The study was based on a grounded theory framework and used as sources the files and accounts of the victims of sexual violence at the Alwaleed center as well as individual interviews conducted at home with the victims and their relatives. Therefore, it was observed that whatever the typical situation in which the victim finds herself, she expresses the trauma she has suffered on a physical, psychological and behavioral level. The trauma suffered by the subjects of type II and III situations comes from the reactions of the family and the community. The trauma suffered by a victim affects the members close to the victim in the same way.
Morphometric Characteristic and Growth Responses of Enhalus acoroides Seedlings Under Different Substrate Composition Treatment
Authors: Nugraha Aditya Hikmat , Almahdi Said , Zahra Aminatul , Karlina Ita 
Published: April 2022

Seagrass transplantation in the large-scale requires a large number of seagrass individu from donor ecosystem. This may give negative impact as damage and reducing the number of seagrass in donor ecosystem. One of methods to overcome this case is by developing transplants using seagrass nut as source for seed. Substrate is one of factors that influence the growth of seagrass. The aim of this study was to compare the effect of differences in substrate composition on morphologi and growth of Enhalus acoroides seeds. Observations were carried out by treatment using mud, sand and mixed substrates sand with mud. The survival rate of Enhalus acoroides seeds was quite high of 100% but it had a lower value of 93.30% on sand substrate. The longest leaf is on the mud substrate with a length of 5.9 cm, the leaf width has the same size in each substrate with a value of 0.4 cm, the highest number of leaves were found in the sand and mixture substrate with 5 strands, the longest root size was in the mixed substrate with a length of 5 cm. The growth of Enhalus acoroides seagrass seeds did not show any significant difference. The highest growth was found in the mud substrate with a value of 0.10 cm/day. Keywords: Enhalus acoroides, seagrass,seed, substrate, transplantation
Floppy Infant-A Case Report of Infantile Pompe Disease With Literature Review
Authors: CHATTERJEE RAJIB , KUMAR PRABHAT 
Published: April 2022

Abstract
Background: Deficiency of acid-α1,4glucosidase results in lysosomal accumulation of glycogen impairing multiple tissue functions i.e., cardiac, skeletal and smooth muscle functions. First described in 1933 by Pompe who identified glycogen by Best carmine in sections of cardiac muscle of an infant who had died of idiopathic cardiac hypertrophy. Hers in 1963 identified the enzyme – α-glucosidase in lysosomes responsible for cleaving glycogen and maltose. He documented deficiency of this enzyme in tissues of patients with Pompe Disease, and thus launched the field of lysosomal storage diseases. Families have been reported with both infantile and late- onset adult forms. Infantile form of Pompe Disease has a more severe enzyme deficiency than late onset forms. Newborn screening reveals an incidence 1:10,000, much higher than in the past. Appearance of a floppy infant presenting in early infancy invokes a differential diagnosis of hypothyroidism, Down’s syndrome, spinal muscular atrophy and less commonly an inborn error of metabolism. History of consanguinity, serial sibling losses and recurrent respiratory infections should arouse suspicion of underlying congenital heart disease. Absence of common structural heart diseases, should focus on functional echocardiography, which was revealing.Case Presentation: Child is the fourth born of second-degree consanguineous marriage with two sibling losses, presented with breathing difficulty at 1-month age. He has a history of frequent hospitalizations for recurrent respiratory tract infections, suggestive of congestive cardiac failure, possibly due to underlying heart disease. Currently at 6-months age, neuromotor and developmental examination reveals a floppy infant. He has history suggestive of developmental delay more marked in gross motor and fine motor abilities, whereas language and social milestones are less affected. Overall, he has a developmental age of three months. Massive hepatomegaly was observed as cardiac failure set in, but it is not solely due to the storage of glycogen in the liver, being part of generalized glycogenoses. Cardiac evaluation revealed cardiomyopathy with concentric left ventricular hypertrophy. Biochemical reports also reflect cardiomyopathy. Dried Blood Spot Assay confirmed clinical suspicion of Pompe Disease which is Glycogen Storage Disease type II, Myozyme funding being pursued.Conclusions: Dried blood spot assay holds the key to early and specific diagnosis. Advent of enzyme replacement therapy with early initiation for this rapidly progressive disease is likely to rewrite a brighter future. Immunomodulating agents such as methotrexate, rituximab and intravenous immune globulin can prevent development of immune response to enzyme replacement therapy. Genetic counseling regarding recurrence risk of such inherited disorders in consanguineous marriages should be accorded priority.
Identification of Function Genes regulating Gastric Cancer progression using Integrated Bioinformatics Analysis
Authors: Yu Kun , Xiao Yao , Yao Qiang , Qian Haiyang , Pan Xin , Wang Gang , Chen Qiong , Zhang Dong , Mei Ke 
Published: April 2022

Abstract
Gastric cancer(GC)is the most frequent cause of cancer with poor prognosis. Treatment for GC remains unchanged in the past few years. This study was done to investigate the potential therapeutic targets and related regulatory biomarkers of Gastric cancer. We obtained the public GC transcriptome sequencing dataset from the GEO database. The datasets contains 348 GC tissues and 141 healthy tissues. In total, 251 DEGs were identified, containing 187 down-regulated genes and 64 up-regulated genes. The DEGs' enriched functions and pathways include Progesterone-mediated oocyte maturation, cell cycle, and oocyte meiosis, Hepatitis B, and Hippo signaling pathway. Survival analysis showed that BUB1, MAD2L1, CCNA2, CCNB1, and BIRC5 might be associated with the regulation the cell cycle phase mitotic spindle checkpoint pathway. We selected 26 regulated genes with the PPI networks' aid analyzed by the Molecular Complex Detection. Then we focused on three critical gene, which is high expressed in gastric cancer, while negatively related to patients survival. Furthermore, we found that knockdown either BIRC5, TRIP13 or UBE2C significantly inhibited cell proliferation, induced cell apoptosis. Knockdown of BIRC5, TRIP13 or UBE2C increased cellular sensitivity to cisplatin. Together, our present study identified significantly upregulated genes with worse prognosis in GC using integrated bioinformatics methods.