bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
Authors: LaMonte Michael J. , Gordon Joshua H. , Diaz‐Moreno Patricia , Andrews Christopher A. , Shimbo Daichi , Hovey Kathleen M. , Buck Michael J. , Wactawski‐Wende J. 
Published: March 2022

Background
Oral microbiota are thought to influence blood pressure (BP) regulation. However, epidemiological data supporting this hypothesis are limited. We examined associations between oral microbiota, BP, and incident hypertension in postmenopausal women.

Methods and Results

Baseline (1997–2001) examinations were completed on 1215 women (mean age, 63 years) during which subgingival plaque was collected, BP was measured, and medical and lifestyle histories and medication inventory were obtained. Microbiome composition of subgingival plaque was measured using 16S ribosomal RNA gene amplicon sequencing. Baseline measured BP was defined as normotensive (systolic <120 mm Hg and diastolic <80 mm Hg, no BP medication use; n=429); elevated (systolic ≥120 mm Hg or diastolic ≥80 mm Hg, no medication use; n=306); or prevalent treated hypertension (history of physician diagnosis treated with medications; n=480). Incident hypertension (375 cases among 735 without baseline treated hypertension) was defined as newly physician‐diagnosed hypertension treated with medication reported on annual health surveys (mean follow‐up, 10.4 years). Cross‐sectional analysis identified 47 bacterial species (of 245 total) that differed significantly according to baseline BP status (
P
<0.05). Prospective analysis identified 15 baseline bacterial species significantly (
P
<0.05) associated with incident hypertension: 10 positively (age‐adjusted hazard ratios [HRs], 1.10–1.16 per SD in bacterial abundance) and 5 inversely (HRs, 0.82–0.91) associated. Associations were materially unchanged after further adjustment for demographic, clinical, and lifestyle factors; were similar when analysis was restricted to the normotensive group; and were of consistent magnitudes between strata of baseline age, smoking, body mass index, and BP categories.

Conclusions
Specific oral bacteria are associated with baseline BP status and risk of hypertension development among postmenopausal women. Research to confirm these observations and elucidate mechanisms is needed.
Assessing China-U.S. Inadvertent Nuclear Escalation
Authors: Riqiang Wu 
Published: March 2022

Abstract
China-U.S. inadvertent escalation has been a focus of recent international relations literature. The current debate, however, has not paid sufficient attention to two important factors: the survivability of China's nuclear forces under unintentional conventional attacks; and China's nuclear command, control, and communication (NC3) system. Based on detailed analysis of these two variables, three potential mechanisms of China-U.S. inadvertent escalation are examined: use-it-or-lose-it, unauthorized/accidental, and damage-limitation. Although the possibility of a major China-U.S. conventional war inadvertently escalating to a nuclear level cannot be excluded, the risk is extremely low. China's nuclear forces would survive U.S. inadvertent conventional attacks and, thus, are unlikely to be significantly undermined. Even though China's NC3 system might be degraded during a conventional war with the United States, Chinese leadership would likely maintain minimum emergency communications with its nuclear forces. Moreover, China's NC3 system is highly centralized, and it prioritizes “negative control,” which can help to prevent escalation. China's nuclear retaliatory capability, although limited, could impede U.S. damage-limitation strikes to some extent. To keep the risk of inadvertent escalation low, both sides must take appropriate precautions and exercise self-restraint in their planning and operations.
A Farewell to Arms? Election Results and Lasting Peace after Civil War
Authors: Daly Sarah Zukerman 
Published: March 2022

Abstract
Why does fighting recur after some civil conflicts, whereas peace consolidates following others? The untested conventional wisdom is that—absent safeguards—postwar elections are dangerous for peace because electoral losers will reject the election results and remilitarize. New cross-national data on postwar election results and belligerent-level data on remilitarization contest this view. Citizens tend to elect peace because they engage in “security voting”; they elect the party that they deem best able to secure the state, using the war outcome as the heuristic that guides their security vote. Findings indicate that the chance of renewed war increases if there is an inversion in the military balance of power after war, and the war-loser performs poorly in the elections. If, instead, relative military power remains stable, or citizens accurately update their understandings of the postwar power balance, a civil war actor is unlikely to remilitarize if it loses the election. Knowing when and how these belligerent electoral actors choose to either sustain or break the peace informs important theoretical and policy debates on how to harness democracy's benefits while mitigating its risks.
Training Deep Convolutional Spiking Neural Networks With Spike Probabilistic Global Pooling
Authors: Lian Shuang , Liu Qianhui , Yan Rui , Pan Gang , Tang Huajin 
Published: March 2022

AbstractRecent work on spiking neural networks (SNNs) has focused on achieving deep architectures. They commonly use backpropagation (BP) to train SNNs directly, which allows SNNs to go deeper and achieve higher performance. However, the BP training procedure is computing intensive and complicated by many trainable parameters. Inspired by global pooling in convolutional neural networks (CNNs), we present the spike probabilistic global pooling (SPGP) method based on a probability function for training deep convolutional SNNs. It aims to remove the difficulty of too many trainable parameters brought by multiple layers in the training process, which can reduce the risk of overfitting and get better performance for deep SNNs (DSNNs). We use the discrete leaky-integrate-fire model and the spatiotemporal BP algorithm for training DSNNs directly. As a result, our model trained with the SPGP method achieves competitive performance compared to the existing DSNNs on image and neuromorphic data sets while minimizing the number of trainable parameters. In addition, the proposed SPGP method shows its effectiveness in performance improvement, convergence, and generalization ability.
Bayesian Brains and the Rényi Divergence
Authors: Sajid Noor , Faccio Francesco , Da Costa Lancelot , Parr Thomas , Schmidhuber Jürgen , Friston Karl 
Published: March 2022

Abstract
Under the Bayesian brain hypothesis, behavioral variations can be attributed to different priors over generative model parameters. This provides a formal explanation for why individuals exhibit inconsistent behavioral preferences when confronted with similar choices. For example, greedy preferences are a consequence of confident (or precise) beliefs over certain outcomes. Here, we offer an alternative account of behavioral variability using Rényi divergences and their associated variational bounds. Rényi bounds are analogous to the variational free energy (or evidence lower bound) and can be derived under the same assumptions. Importantly, these bounds provide a formal way to establish behavioral differences through an α parameter, given fixed priors. This rests on changes in α that alter the bound (on a continuous scale), inducing different posterior estimates and consequent variations in behavior. Thus, it looks as if individuals have different priors and have reached different conclusions. More specifically, α→0+ optimization constrains the variational posterior to be positive whenever the true posterior is positive. This leads to mass-covering variational estimates and increased variability in choice behavior. Furthermore, α→+∞ optimization constrains the variational posterior to be zero whenever the true posterior is zero. This leads to mass-seeking variational posteriors and greedy preferences. We exemplify this formulation through simulations of the multiarmed bandit task. We note that these α parameterizations may be especially relevant (i.e., shape preferences) when the true posterior is not in the same family of distributions as the assumed (simpler) approximate density, which may be the case in many real-world scenarios. The ensuing departure from vanilla variational inference provides a potentially useful explanation for differences in behavioral preferences of biological (or artificial) agents under the assumption that the brain performs variational Bayesian inference.
Understanding the Computational Demands Underlying Visual Reasoning
Authors: Vaishnav Mohit , Cadene Remi , Alamia Andrea , Linsley Drew , VanRullen Rufin , Serre Thomas 
Published: March 2022

Abstract
Visual understanding requires comprehending complex visual relations between objects within a scene. Here, we seek to characterize the computational demands for abstract visual reasoning. We do this by systematically assessing the ability of modern deep convolutional neural networks (CNNs) to learn to solve the synthetic visual reasoning test (SVRT) challenge, a collection of 23 visual reasoning problems. Our analysis reveals a novel taxonomy of visual reasoning tasks, which can be primarily explained by both the type of relations (same-different versus spatial-relation judgments) and the number of relations used to compose the underlying rules. Prior cognitive neuroscience work suggests that attention plays a key role in humans' visual reasoning ability. To test this hypothesis, we extended the CNNs with spatial and feature-based attention mechanisms. In a second series of experiments, we evaluated the ability of these attention networks to learn to solve the SVRT challenge and found the resulting architectures to be much more efficient at solving the hardest of these visual reasoning tasks. Most important, the corresponding improvements on individual tasks partially explained our novel taxonomy. Overall, this work provides a granular computational account of visual reasoning and yields testable neuroscience predictions regarding the differential need for feature-based versus spatial attention depending on the type of visual reasoning problem.
On the Intersection between Variational and Contrastive Pragmatics: An Analysis of Requests for Repair in Complaints by German-Speaking Belgians
Authors: Lochtman Katja 
Published: March 2022

Abstract
Most research on German as a pluricentric language to date has focused on differences between the standard varieties in Germany, Austria or Switzerland. Moreover, the focus in these studies is mainly on linguistic-structural features, with pragmatic differences (if any) only briefly touched upon. In Belgium, German is a minority language within a region, where French is the dominant language, resulting in both individual and societal language contact. By looking at the realisation of requests for repair in complaints across varieties of the same language on the one hand and different languages on the other, the present study wants to identify whether there are variety specific pragmatic features of Belgian German as opposed to German in Germany and Belgian French. Researching both intra- and interlingual pragmatic differences, the present study can be situated at the interface between variational and contrastive pragmatics.
The Impacts of Immersion Ice Nucleation Parameterizations on Arctic Mixed-Phase Stratiform Cloud Properties and the Arctic Radiation Budget in GEOS-5
Authors: Tan Ivy , Barahona Donifan 
Published: March 2022

Abstract
The influence of four different immersion freezing parameterizations on Arctic clouds and the top-of-the atmosphere (TOA) and surface radiation fluxes is investigated in the fifth version of the National Aeronautics and Space Administration (NASA) Goddard Earth Observing System (GEOS-5) with sea surface temperature, sea ice fraction, and aerosol emissions held fixed. The different parameterizations were derived from a variety of sources, including classical nucleation theory and field and laboratory measurements. Despite the large spread in the ice-nucleating particle (INP) concentrations in the parameterizations, the cloud properties and radiative fluxes had a tendency to form two groups, with the lower INP concentration category producing larger water path and low-level cloud fraction during winter and early spring, whereas the opposite occurred during the summer season. The stability of the lower troposphere was found to strongly correlate with low-cloud fraction and, along with the effect of ice nucleation, ice sedimentation, and melting rates, appears to explain the spring-to-summer reversal pattern in the relative magnitude of the cloud properties between the two categories of simulations. The strong modulation effect of the liquid phase on immersion freezing led to the successful simulation of the characteristic Arctic cloud structure, with a layer rich in supercooled water near cloud top and ice and snow at lower levels. Comparison with satellite retrievals and in situ data suggest that simulations with low INP concentrations more realistically represent Arctic clouds and radiation.
Combined Space- and Ground-Based GNSS Monitoring of Two Severe Hailstorm Cases in Bulgaria
Authors: Lasota Elżbieta , Slavchev Martin , Guerova Guergana , Rohm Witold , Kapłon Jan 
Published: March 2022

Abstract
Monitoring atmospheric conditions that lead to severe weather events is critical to their timely and accurate prediction and can help prevent of large economic losses. Bulgaria, located in southeastern Europe, has the highest mean number of thunderstorms and hailstorms. These events generally occur between April and September with a peak in July. In this study, both radio occultation (RO) and ground-based observations from the Global Navigation Satellite Systems (GNSS) were used to study two severe hailstorms that occurred in 2014 and 2019. In both storms, a cold upper-air pool was detected in addition to a large specific humidity anomaly between 2 and 6 km. In the hailstorm that occurred in July 2014, there was an RO temperature anomaly between 10 and 14 km as well as a positive specific humidity anomaly between 4 and 6 km. The integrated vapor transport (IVT) reanalysis from ERA5, indicated that the high specific humidity over the Mediterranean could be tracked to an atmospheric river over the North Atlantic, which was connected to a tropical cyclone. In the hailstorm that occurred in May 2019, elevated IVT values were observed before the storm. During this storm, a negative temperature anomaly peak was observed in the RO profile at 11.3 km as well as a positive specific humidity anomaly between 2 and 4.5 km. The WRF Model and the ERA5 dataset could reproduce the temperature profiles for both storms relatively well; however, they tended to underestimate specific humidity. The RO profiles were complemented by ground-based GNSS tropospheric delays with high temporal resolution. The evaluation of the WRF with ground-based GNSS tropospheric products revealed a time delay between the modeled and observed developments of both hailstorms.
Faecal haemoglobin concentration in adenoma, before and after polypectomy, approaches the ideal tumour marker
Authors: Mowat Craig , Digby Jayne , Cleary Shirley , Gray Lynne , Datt Pooja , Goudie David R , Steele Robert JC , Strachan Judith A , Humphries Adam , Fraser Callum G 
Published: March 2022

Background Polypectomy may be performed at colonoscopy and then subsequent surveillance undertaken. It is thought that faecal haemoglobin concentration (f-Hb), estimated by quantitative faecal immunochemical tests (FIT), might be a useful tumour marker. Methods Consecutive patients enrolled in colonoscopy surveillance were approached at two hospitals. A specimen for FIT was provided before colonoscopy and, ideally after 3 weeks, a second FIT sample from those who had polypectomy. A single FIT system (OC-Sensor io, Eiken Chemical Co., Ltd) was used to generate f-Hb. Results 1103 Patients were invited; 643 returned a FIT device (uptake: 58.3%). Four patients had known inflammatory bowel disease (IBD) and were excluded, leaving 639 (57.9%) with an age range of 25–90 years (median 64 years), 54.6% male. Of 593 patients who had a f-Hb result and completed colonoscopy, advanced neoplasia was found in 41 (6.9%); four colorectal cancer (CRC): 0.7% and 37 advanced adenoma (AA): 6.3%, and a further 127 (21.4%) had non-advanced adenoma (NAA). The median f-Hb was significantly greater in AA as compared to NAA; 6.0 versus 1.0 μg Hb/g faeces, p < 0.0001.134/164 (81.7%) of invited patients returned a second FIT device: 28 were patients with AA in whom median pre-polypectomy f-Hb was 19.2, falling to 3.5 μg Hb/g faeces post-polypectomy, p = 0.01, and 106 with NAA had median pre-polypectomy f-Hb 0.8 compared to 1.0 μg Hb/g faeces post-polypectomy, p = 0.96. Conclusions Quantitative FIT could provide a good tumour marker in post-polypectomy surveillance, reduce colonoscopy requirements and minimise potential risk to patients.
Prophylactic dexmedetomidine use did not decrease the incidence of delirium in patients undergoing cardiac surgery: A meta-analysis
Authors: Li Wen , Liu Huiyu , Yang Chuanhua 
Published: March 2022

Objective The benefits of prophylactic dexmedetomidine use in patients undergoing cardiac surgery remain controversial. The aim of this meta-analysis was to investigate the short-term clinical outcomes of dexmedetomidine use versus non-dexmedetomidine use. Methods Systematic searches using PubMed, Embase, and the Cochrane Library were carried out for English articles published from inception to 23 September 2021. This was followed by a meta-analysis investigating delirium, the length of delirium, mortality, bradycardia, hypotension, the length of intensive care unit (ICU) and hospital stay, and the duration of mechanical ventilation. Results Ten randomized controlled trials (RCTs) totaling 2550 patients were included. In the dexmedetomidine group incidence of delirium was 13.5%, compared with 16.1% in the control group. The risk ratio (RR) for the comparison was 0.69 (95% CI, 0.47 – 1.00; p = .052). In addition, there were no differences in mortality (RR, 0.56; 95% CI, 0.27 – 1.14; p = .109), the incidence of bradycardia (RR, 1.20; 95% CI, 0.91 – 1.57; p = .201), the incidence of hypotension (RR, 0.90; 95% CI, 0.57 – 1.44; p = .674), and the length of delirium mean difference (MD, −0.99; 95% CI, −2.20 to 0.21; p = .106). However, prophylactic dexmedetomidine use significantly reduced the duration of mechanical ventilation (MD, −2.03; 95% CI, −3.35 to −0.70; p = .003), length of ICU stay (MD, −3.17; 95% CI, −5.10 to −1.24; p = .001), and length of hospital stay (MD, −1.76; 95% CI, −2.88 to −0.66; p = .002). Conclusions Prophylactic dexmedetomidine use did not decrease the incidence of delirium in patients undergoing cardiac surgery, but significantly reduced the duration of mechanical ventilation, length of ICU stay, and length of hospital stay.
Recovery and patient satisfaction following radiofrequency ablation and concomitant foam sclerotherapy of varicose veins with and without compression: A randomized controlled non-inferiority trial
Authors: Pihlaja Toni , Mella Minna , Ohtonen Pasi , Romsi Pekka , Pokela Matti 
Published: March 2022

Background The benefits of postoperative compression are not well established following radiofrequency ablation of the truncal vein and concomitant foam sclerotherapy. Methods A total of 104 patients were randomized: Postoperatively, 54 patients received no compression and 50 patients received class II thigh-high compression. The primary outcome for this study was the difference between means on postoperative pain scores over the first 10 days follow-up measured on a visual analog scale (VAS) from 0 to 100 mm (prespecified delta 10 mm). Results The difference between means in no compression and compression group on postoperative pain scores over the 10 days follow-up was 2.1 mm (95% confidence interval −5.1–9.3 mm; p = 0.28) indicating non-inferiority. Patients in the no compression group were more satisfied with the visual appearance of the treated leg at 1 month ( p = 0.003). Conclusion Over the first 10 postoperative days, no compression was non-inferior to compression on pain scores.
A Single Stage Composite Cleft Septorhinoplasty for Correction of the Mature Unilateral Cleft Nose Deformity - The Gujrat Technique
Authors: Othman Diaa , Gorman Mark , Abbas Khan Muhammad Adil , Ma Yangmyung , Bhatti Dujanah Siddique , Rafiq Sadia , Shami Hussan Berkhez , Lye George , McBride Michael , Riaz Muhammad 
Published: March 2022

Objective To evaluate the results of a single stage composite cleft septorhinoplasty procedure (“The Gujrat Technique”) to correct the exaggerated cleft nose deformity after completion of nasal growth in an adult patient cohort. Methods Adult patients with a residual unilateral cleft nasal deformity were deemed eligible for the proposed “Gujrat Technique”. Over a 10-year period (2007–2017), 96 adult patients underwent this composite cleft septorhinoplasty as a single stage operation. Post-operative nasal symmetry evaluation was undertaken using the validated computer program ‘SymNose’. Functional outcome and patient satisfaction were assessed using Nasal Obstruction Symptom Evaluation scale and Rhinoplasty Outcome Evaluation (ROE) questionnaires respectively. Various statistical analysis methods were used to validate the obtained results. Results Due to poor compliance with follow-up, post-operative assessments were undertaken in only 32 patients. The single group study design using the non-parametric matching pairs Wilcoxon Sign test (p < 0.001) showed overall good to excellent functional and aesthetic outcomes and higher scores of the digital SymNose grading system. There was a significant improvement in ROE scores (from 26.4 ± 2.9 to 85.9 ± 4.7, p < 0.001). There were no major complications or revisions needed in our series. Conclusion The individual components of "The Gujrat Technique" are not novel but their combination in this adult unilateral cleft rhinoplasty cohort has demonstrated a high patient satisfaction with its aesthetic appeal and functional versatility. In the background of limited resources and unpredictable patient follow up, the simplicity, reproducibility and cost effectiveness of this technique make it a practical reconstructive option.