bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of tibial alignment parameters based on clinically relevant anatomical landmarks
Authors: Jang Seong J. , Kunze Kyle N. , Brilliant Zachary R. , Henson Melissa , Mayman David J. , Jerabek Seth A. , Vigdorchik Jonathan M. , Sculco Peter K. 
Published: October 2022

AimsAccurate identification of the ankle joint centre is critical for estimating tibial coronal alignment in total knee arthroplasty (TKA). The purpose of the current study was to leverage artificial intelligence (AI) to determine the accuracy and effect of using different radiological anatomical landmarks to quantify mechanical alignment in relation to a traditionally defined radiological ankle centre.MethodsPatients with full-limb radiographs from the Osteoarthritis Initiative were included. A sub-cohort of 250 radiographs were annotated for landmarks relevant to knee alignment and used to train a deep learning (U-Net) workflow for angle calculation on the entire database. The radiological ankle centre was defined as the midpoint of the superior talus edge/tibial plafond. Knee alignment (hip-knee-ankle angle) was compared against 1) midpoint of the most prominent malleoli points, 2) midpoint of the soft-tissue overlying malleoli, and 3) midpoint of the soft-tissue sulcus above the malleoli.ResultsA total of 932 bilateral full-limb radiographs (1,864 knees) were measured at a rate of 20.63 seconds/image. The knee alignment using the radiological ankle centre was accurate against ground truth radiologist measurements (inter-class correlation coefficient (ICC) = 0.99 (0.98 to 0.99)). Compared to the radiological ankle centre, the mean midpoint of the malleoli was 2.3 mm (SD 1.3) lateral and 5.2 mm (SD 2.4) distal, shifting alignment by 0.34o(SD 2.4o) valgus, whereas the midpoint of the soft-tissue sulcus was 4.69 mm (SD 3.55) lateral and 32.4 mm (SD 12.4) proximal, shifting alignment by 0.65o(SD 0.55o) valgus. On the intermalleolar line, measuring a point at 46% (SD 2%) of the intermalleolar width from the medial malleoli (2.38 mm medial adjustment from midpoint) resulted in knee alignment identical to using the radiological ankle centre.ConclusionThe current study leveraged AI to create a consistent and objective model that can estimate patient-specific adjustments necessary for optimal landmark usage in extramedullary and computer-guided navigation for tibial coronal alignment to match radiological planning. Cite this article: Bone Jt Open 2022;3(10):767–776.
A New Elastic Non Contacting Sealing Concept for Valves
Authors: Matthias Scherrer , Rudolf Scheidl , Evgeny Luckachev 
Published: October 2022

The hydraulic binary counter concept was proposed as a means to realize compact and lightweight digital hydraulic cylinder drives for exoskeleton actuation. This counter principle is based on hydraulically actuated switching valves which have a hysteretic response with respect to the pilot pressure. Manufacturing tolerances of the tiny components caused unexpected high leakage which, in turn, led to a malfunction of the system.
In this paper a new sealing concept, is introduced to solve this problem. It is based on a non-contact seal (sealing gap), which exploits a self-regulating, elasto-hydrodynamic effect to reduce a rather large initial gap h0 – to allow a rough tolerance – into a very small sealing gap h(x) to avoid dry friction of valve spool movement on the one hand but have very small leakage on the other hand.
As sealing, an annular flexible ring made, e.g. of PTFE, is used which combines sufficient flexibility to allow this self adapting mechanism to a sufficient extent and to stay the high pressure loads.
For the mathematical analysis of the concept, an approximate elasto-hydrodynamic analytical model is used. It sets the gap pressure, obtained from the Reynold’s equation for the sealing gap, the elastic restoring forces of the sealing ring, and the imparting pressure in equilibrium.
The sealing concept is then simulated with a numerical model built with the finite element code ABAQUS, this results are compared with the one of the analytical model.
It solves the Reynolds equation by a user defined subroutine. The simulation results indicate that this sealing principle delivers way better results than standard gap seals despite its rough manufacturing tolerances with one order of magnitude higher tolerance ranges. The application of this concept is not limited to small valves as needed for exoskeleton hydraulics but can be transferred to conventional type of hydraulics as well.
Challenges of Machine Learning for eVTOL Reliability and Safety
Authors: Salvador Marcos Aurelio 
Published: October 2022

The increasing number of requests for type certification received by the European Union Safety Agency on Vertical Takeoff and Landing (VTOL) aircraft attests to the expansion of frontiers in Urban Air Mobility (UAM). In addition, it has revealed the interest of traditional airplane and helicopter manufacturers in this new technology, all the while highlighting the emergence of new players developing their respective versions of electric-powered VTOLs (eVTOL). The perspective of eVTOLs going into service in the coming years for the transport of passengers raises new safety concerns. Indeed, it is necessary to ensure the reliability and safety aspects of those aircraft systems that will be flying under new operational missions, differing from current fixed wing (airplanes) and rotorcraft (helicopters) aircraft. At the same time, the evolution of aircraft systems monitoring technology is making it possible to acquire increasing amounts of data. The high complexity of new systems, combined with the huge amount of data provided, can make the decision-making process more difficult for pilots. Machine learning makes it possible to evaluate this data and improve reliability and safety.
Even as the number of aeronautical accidents has decreased over the last years, 60–80% of those accidents are the result of human failure. In the initial implementation and operation stages of eVTOLs, machine learning (ML) can support pilots by using aircraft data to predict system failures and contribute to improve reliability and safety. Then, at an advanced stage of eVTOL operation, ML may help reduce human interaction with the aircraft, paving the way toward fully autonomous aircraft. The association of ML with technologies such as Digital Twins and 6G networks has the potential to enable safe and reliable autonomous flight. However, the introduction of eVTOLs will also increase air traffic in highly populated areas and thus needs to be studied to support the incorporation of the future autonomous aircraft. This paper addresses the main challenges for the incorporation of ML in the upcoming eVTOL fleet and its potential contribution to aircraft systems reliability and safety. It also explores the need for the use of ML techniques in a more autonomous air traffic management systems the face of increased air traffic.
Social Media Insights About COVID-19 in Portugal: A Text Mining Approach
Authors: Marreiros Carolina Ferraz , Bone João , Ferreira Joao C. , Ribeiro Ricardo 
Published: October 2022

The rapid spread of COVID-19 around the world had a significant impact on daily life. As in other countries, measures were taken in Portugal to combat the exponential increase of cases, such as curfews and the use of masks. Thus, in parallel with the direct consequences on health and the healthcare sector, the pandemic also caused changes in human behavior from a sociological viewpoint.
The objective of this dissertation is to attain a perception of the reality concerning COVID-19. For this purpose, real-time data was extracted from three sources, two of them being social media platforms – Twitter and Reddit – and the other one being Público, a Portuguese online newspaper. The adopted approach, based on topic modelling and sentiment analysis, was validated within the Portugal context, concerning data over a period of one year, but it can equally be employed in similar situations and other countries and provide decision-making support.
After the data extracting, it was prepared for application of natural language processing (NLP) tools specific to the Portuguese language, which can represent a challenge due to the lexical richness. With the gathered information, a dashboard was built, with the purpose of gaining insights on the COVID-19 pandemic in Portugal. It was concluded that the topics discussed on social media reflect the events related to the pandemic. In a final stage, these dashboards were evaluated by public health experts, who highlighted the potential of the results obtained. The data and dashboards will be made available to the scientific community upon request.
Comparison of ultrasonography and fluoroscopy as guides for extracorporeal shock wave lithotripsy in nephrolithiasis patients: a systematic review
Authors: Duarsa Gede Wirya Kusuma , Putra Christian Nurtanto , Ivandi Kevin , Wiryadana Kadek Adit , Tirtayasa Pande Made Wisnu , Pribadi Firman 
Published: October 2022

BACKGROUND Extracorporeal shock wave lithotripsy (ESWL) is one of the first-line treatment options for patients with renal stones <2 cm. The large variability in ESWL results may be due to the stone visualization methods using ultrasonography (USG), fluoroscopy, or a combination of both. This study aimed to review the efficacy and safety of the stone visualization method on the stone-free rate (SFR) and postprocedural complications in nephrolithiasis patients.
METHODS We conducted a systematic review of USG and fluoroscopy on ESWL until July 2022, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We assessed and collected summaries of the screened papers. The main outcomes assessed were the SFR of renal stones and postprocedural complications between imaging modalities.
RESULTS A total of 7 studies were assessed, including 6 comparative assessments of USG versus fluoroscopy and 1 comparative assessment of USG and fluoroscopy versus fluoroscopy only. Although all studies showed that USG had a higher SFR than fluoroscopy, only 1 study showed a significant difference (p = 0.008). Additionally, superior results were obtained using a combination of USG and fluoroscopy compared with fluoroscopy only. Most studies agreed that USG was not inferior in post-ESWL complication results.
CONCLUSIONS Overall, the use of USG is comparable to fluoroscopy because it does not provide a significant difference in the SFR and complications. In most cases, USG is preferred because of the absence of radiation. The combination of fluoroscopy and USG also provides more promising results than a single modality.
Effect of optical spatial coherence on localized spin angular momentum density in tightly focused light [Invited]
Authors: Wang Zixuan , Yan Chencheng , Wang Fei , Chen Yahong , Cai Yangjian 
Published: October 2022

Optical coherence is one of the most fundamental characteristics of light and has been viewed as a powerful tool for governing the spatial, spectral, and temporal statistical properties of optical fields during light–matter interactions. In this work, we use the optical coherence theory developed by Emil Wolf as well as the Richards–Wolf’s vectorial diffraction method to numerically study the effect of optical coherence on the localized spin density of a tightly focused partially coherent vector beam. We find that both the transverse spin and longitudinal spin, with the former induced by the out-of-phase longitudinal field generated during strong light focusing and the latter induced by the vortex phase in the incident beam, are closely related to the optical coherence of the incident beam, i.e., with the decrease of the transverse spatial coherence width of the incident beam, the magnitude of the spin density components decreases as well. The numerical findings are interpreted well with the two-dimensional degrees of polarization between any two of the three orthogonal field components of the tightly focused field. We also explore the roles of the topological charge of the vortex phase on enhancing the spin density for the partially coherent tightly focused field. The effect of the incident beam’s initial polarization state is also discussed.
Bi-tunable absorber based on borophene and VO2 in the optical telecommunication band
Authors: Yang Chao , Lin Qi , Du Wen-Juan , Wang Ling-Ling , Liu Gui-Dong 
Published: October 2022

We propose a bi-tunable absorber based on a single layer of borophene, silica grating, and vanadium dioxide (

V
O

2

) in the telecommunication band. The numerical simulation results show that the perfect absorption can be achieved at 1353 nm when the electron density of the borophene layer is

n
=

3.5

×

1

0

19

m

−
2

and the

V
O

2

layer is in the metallic phase because the borophene layer is assisted by grating and the Fabry–Perot resonator is formed by the absorber. More importantly, the absorption peak and absorption amplitude can be independently tuned by regulating the electron density of the borophene layer and the insulator-metal transition (IMT) of the

V
O

2

layer. The absorption peak can be tuned in a wide range by altering the electron density while the absorption is maintained above 0.95 in the optical telecommunication band. The absorption amplitude also can be dynamically adjusted from 0.61 to 0.95 by the IMT of the

V
O

2

layer when the electron density of the borophene layer is

n
=

2.5

×

1

0

19

m

−
2

. In addition, for oblique incidence from 0° to 40°, the proposed absorber can maintain high absorption performance of more than 0.95. The absorber achieves dynamic regulation of the absorption peak and amplitude by two independent methods, which provide guidance for the research of intelligent and tunable devices.
Experiences of living with leprosy: A systematic review and qualitative evidence synthesis
Authors: Abdul Rahman Norana , Rajaratnam Vaikunthan , Burchell George L. , Peters Ruth M. H. , Zweekhorst Marjolein B. M. 
Published: October 2022

Objective
The objective of the review was to identify, appraise, and synthesise qualitative studies on the lived experience of individuals diagnosed with leprosy, the impact of the disease, and how they coped with the disease burden.

Introduction
Leprosy is a chronic disease with long-term biopsychosocial impact and is a leading cause of preventable disabilities. It traps the individuals with leprosy in a vicious circle of disease, stigma, and poverty. The efforts to reduce stigma and discrimination and improve their quality of life have not kept pace with the success of the multidrug treatment.

Inclusion criteria
This review considered published literature on the lived experience of individuals diagnosed with leprosy. There were no limitations on gender, background, or country. All qualitative or mixed-methods studies were accepted.

Methods
The review followed the JBI meta-aggregation approach for qualitative systematic reviews. A structured literature search was undertaken using multiple electronic databases: PubMed, Embase, Web of Science, and CINAHL.

Results
The search identified 723 publications, and there were 446 articles after deduplication. Forty-nine studies met the inclusion criteria. The final 173 findings were synthesised into ten categories and aggregated into four synthesised findings: biophysical impact, social impact, economic impact, and mental and emotional impact. These synthesised findings were consistent across the included studies from a patient’s perspective. The way people coped with leprosy depended on their interpretation of the disease and its treatment. It affected their help-seeking behaviour and their adherence to treatment and self-care. The review has identified a multi-domain effect on the affected individuals, which goes beyond the biological and physical effects, looking at the social issues, specific difficulties, emotions, and economic hardships.

Conclusions
The researchers, health professionals, and policymakers could use the synthesised findings to address the concerns and needs of the leprosy-affected individuals and offer appropriate support to manage their lives.

Systematic review registration number
PROSPERO Registration number: CRD42021243223
High-flow nasal cannula oxygen therapy for admitted COPD-patients. A retrospective cohort study
Authors: Veenstra Pieter , Veeger Nic J. G. M. , Koppers Ralph J. H. , Duiverman Marieke L. , van Geffen Wouter H. 
Published: October 2022

Background
The use of High-flow nasal cannula (HFNC) is increasing in admitted COPD-patients and could provide a step in between non-invasive ventilation (NIV) and standard oxygen supply. Recent studies demonstrated that HFNC is capable of facilitating secretion removal and reduce the work of breathing. Therefore, it might be of advantage in the treatment of acute exacerbations of COPD (AECOPD). No randomized trials have assessed this for admitted COPD-patients on a regular ward and only limited data from non-randomized studies is available.

Objectives
The aim of our study was to identify the reasons to initiate treatment with HFNC in a group of COPD-patients during an exacerbation, further identify those most likely to benefit from HFNC treatment and to find factors associated with treatment success on the pulmonary ward.

Material and methods
This retrospective study included COPD-patients admitted to the pulmonary ward and treated with HFNC from April 2016 until April 2019. Only patients admitted with severe acute exacerbations were included. Patients who had an indication for NIV-treatment where treated with NIV and were included only if they subsequently needed HFNC, e.g. when they did not tolerate NIV. Known asthma patients were excluded.

Results
A total of 173 patients were included. Stasis of sputum was the indication most reported to initiate HFNC-treatment. Treatment was well tolerated in 83% of the patients. Cardiac and vascular co-morbidities were significantly associated with a smaller chance of successful treatment (Respectively OR = 0.435; p = 0.013 and OR = 0.493;p = 0.035). Clinical assessment judged HFNC-treatment to be successful in 61% of the patients. Furthermore, in-hospital treatment with NIV was associated with a higher chance of HFNC failure afterwards (OR = 0.439; p = 0.045).

Conclusion
This large retrospective study showed that HFNC-treatment in patients with an AECOPD was initiated most often for sputum stasis as primary reason. Factors associated with improved outcomes of HFNC-treatment was the absence of vascular and/or cardiac co-morbidities and no need for in-hospital NIV-treatment.
Removal of glycerol from biodiesel using multi-stage microfiltration membrane system: industrial scale process simulation
Authors: Kusumocahyo Samuel P. , Redulla Rachel C. , Fulbert Kevin , Iskandar Aulia A. 
Published: October 2022

Abstract
Biodiesel purification is one of the most important downstream processes in biodiesel industries. The removal of glycerol from crude biodiesel is commonly conducted by an extraction method using water, however this method results in a vast amount of wastewater and needs a lot of energy. In this study, microfiltration membrane was used to remove glycerol from biodiesel, and a process simulation was carried out for an industrial scale biodiesel purification plant using a microfiltration membrane system. The microfiltration experiment using a simulated feed solution of biodiesel containing glycerol and water showed that the membrane process produced purified biodiesel that met the international standards. The result of the process simulation of a multi-stage membrane system showed that the membrane area could be minimized by optimizing the concentration factor of every stage with the aid of a computer program that was written in Phyton programming language with Visual Studio Code. The overall productivity of a single stage membrane system was the same with that of the multi-stage system, however the single stage system required a larger membrane area. To produce 750 m3 day−1 of purified biodiesel, a multi-stage membrane system consisting of 10 membrane modules required a total membrane area of 1515 m2 that was 57% smaller compared to the single stage system consisting of one membrane module. This membrane area reduction was equivalent to a reduction of the total capital cost of 30%. Based on the analysis of the total capital cost, it was found that the optimum number of stages was 4 since it showed a minimum value of the total capital cost with a membrane area of 1620 m2 that was equivalent to the reduction of the total capital cost of 34%. The result of this simulation showed that the multi-stage microfiltration membrane has great potential to replace the conventional method in biodiesel industries.
Cathelicidin as a marker for subclinical cardiac changes and microvascular complications in children and adolescents with type 1 diabetes
Authors: Matter Randa M. , Nasef Marwa Waheed A. , ShibaAlhamd Reham M. , Thabet Rasha Adel 
Published: October 2022

Abstract

Objectives
To detect cathelicidin levels in pediatric patients with type 1 diabetes (T1D) as a potential marker for diabetic vascular complications and to assess its relation to diastolic dysfunction as an index for subclinical macrovasculopathy.

Methods
Totally, 84 patients with T1D were categorized into three groups; newly diagnosed diabetes group (28 patients with a mean age of 12.38 ± 1.99) years, T1D without microvascular complications group (28 patients with a mean age of 13.04 ± 2.27), and T1D with microvascular complications group (28 patients with a mean age of 13.96 ± 2.30). Patients were evaluated using serum cathelicidin levels and echocardiography.

Results
Total cholesterol, microalbuminuria, and cathelicidin levels were significantly higher in patients with microvascular complications when compared to the other two groups (p<0.001). Additionally, carotid intima-media thickness (CIMT) echocardiography values and diastolic functions were significantly higher in patients with complications (p<0.001). Cathelicidin was positively correlated to the duration of diabetes (r=0.542, p<0.001), total cholesterol (r=0.346, p=0.001), recurrence of hypoglycemia (r=0.351, p=0.001), recurrence of diabetes ketoacidosis (r=0.365, p=0.001), CIMT (r=0.544, p<0.001), and E/A values (r=0.405, p<0.001).

Conclusions
Serum cathelicidin levels can be used as an early marker for the occurrence and progression of vascular complications in patients with T1D.