bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Of thee I sing”: An opening to Dominique Boutet’s kinesiological approach to gesture
Authors: Morgenstern Aliyah , Chevrefils Lea , Blondel Marion , Vincent Coralie , Thomas Chloé , Jego Jean-François , Boutet Dominique 
Published: January 2022

In this tribute to Dominique Boutet and the kinesiological approach he founded, the authors have tried to make their memories of the scientific collective projects they worked on together resonate with the written work of this extraordinary scientific partner, gathered in his published articles and his habilitation document (Boutet 2018). His approach based on an intimate knowledge of the biomechanics of the human body is centered on the structuring role of the body in gestures (and signed languages). It is form-based: the form of gestures shapes their meaning or function. Gestural units are described on the basis of their formal characteristics and physiological constraints rather than their imagistic iconicity.
The article presents the foundations of the approach, a synoptic description and some examples of its application. The originality of the kinesiological approach lies in the double revolution that it allows us to operate: on the one hand, gesture is not simply an appendix of speech; on the other hand; it is shaped by bodily physiology. The approach is based on the movements of the human body analyzed from a biomechanical point of view. The meaning of our gestural productions is the produce of our body, as it is naturally articulated, imprinted as it is by our past experiences.
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody
Authors: Mørtberg Trude V , Zhi Huiying , Vidarsson Gestur , Foss Stian , Lissenberg-Thunnissen Suzanne , Wuhrer Manfred , Michaelsen Terje E , Skogen Bjørn , Stuge Tor B , Andersen Jan Terje , Newman Peter J , Ahlen Maria Therese 
Published: January 2022

Abstract
Maternal alloantibodies toward paternally inherited Ags on fetal platelets can cause thrombocytopenia and bleeding complications in the fetus or neonate, referred to as fetal and neonatal alloimmune thrombocytopenia (FNAIT). This is most commonly caused by Abs against the human platelet Ag (HPA)-1a in Caucasians, and a prophylactic regimen to reduce the risk for alloimmunization to women at risk would be beneficial. We therefore aimed to examine the prophylactic potential of a fully human anti–HPA-1a IgG1 (mAb 26.4) with modified Fc region or altered N-glycan structures. The mAb 26.4 wild-type (WT) variants all showed efficient platelet clearance capacity and ability to mediate phagocytosis independent of their N-glycan structure, compared with an effector silent variant (26.4.AAAG), although the modified N-glycan variants showed differential binding to FcγRs measured in vitro. In an in vivo model, female mice were transfused with platelets from transgenic mice harboring an engineered integrin β3 containing the HPA-1a epitope. When these preimmunized mice were bred with transgenic males, Abs against the introduced epitope induced thrombocytopenia in the offspring, mimicking FNAIT. Prophylactic administration of the mAb 26.4.WT, and to some extent the mAb 26.4.AAAG, prior to platelet transfusion resulted in reduced alloimmunization in challenged mice and normal platelet counts in neonates. The notion that the effector silent variant hampered alloimmunization demonstrates that rapid platelet clearance, as seen with mAb 26.4.WT, is not the sole mechanism in action. Our data thus successfully demonstrate efficient Ab-mediated immunosuppression and prevention of FNAIT by anti–HPA-1a monoclonal variants, providing support for potential use in humans.
The E26 Transformation–Specific Family Transcription Factor Spi-C Is Dynamically Regulated by External Signals in B Cells
Authors: Raczkowski Hannah L , Xu Li S , Wang Wei Cen , DeKoter Rodney P 
Published: January 2022

Abstract
Spi-C is an E26 transformation-specific transcription factor closely related to PU.1 and Spi-B. Spi-C has lineage-instructive functions important in B cell development, Ab-generating responses, and red pulp macrophage generation. This research examined the regulation of Spi-C expression in mouse B cells. To determine the mechanism of Spic regulation, we identified the Spic promoter and upstream regulatory elements. The Spic promoter had unidirectional activity that was reduced by mutation of an NF-κB binding site. Reverse transcription-quantitative PCR analysis revealed that Spic expression was reduced in B cells following treatment with cytokines BAFF + IL-4 + IL-5, anti-IgM Ab, or LPS. Cytochalasin treatment partially prevented downregulation of Spic. Unstimulated B cells upregulated Spic on culture. Spic was repressed by an upstream regulatory region interacting with the heme-binding regulator Bach2. Taken together, these data indicate that Spi-C is dynamically regulated by external signals in B cells and provide insight into the mechanism of regulation.
Carotid Endarterectomy and Carotid Artery Stenting for Symptomatic Carotid Stenosis
Authors: Diyora Batuk , Chheda Rushabh M , Dhall Gagan , Gupta Pradeep , Dewani Kavin , Mulla Mazharkhan , Gaud Darshan 
Published: January 2022

Background:
Stenosis of the ICA is an important cause of ischemic stroke and associated morbidity and mortality. Carotid artery stenting (CAS) and carotid endarterectomy (CEA) help to prevent impending or subsequent ischemic stroke in such patients.

Aim and Objective:

Material and Methods:
From Jan 2014–Dec 2017, 80 patients presented with symptomatic carotid stenosis. Out of these 80 patients, 65 underwent intervention; 34 patients underwent CEA and 31 patients underwent CAS. Pre-defined variables like age, sex, and degree of stenosis were assessed as potential risk factors, and the patients' clinical features, radiological imaging, and procedural complications were documented.

Results:
The primary outcome of procedure-related stroke, major adverse events (MAEs), and death at 30 days follow-up and long-term outcomes of restenosis at 1 year were analyzed. Peri-procedural stroke occurred in 2 cases (6.4%) of CAS; one suffered an ischemic stroke and other suffered a hemorrhagic stroke. Three cases of CEA suffered procedure-related events; one (2.9%) suffered TIA while the other two developed postoperative local hematoma without neurological deficit; one was treated conservatively while the other required re-exploration due to pressure symptoms. Restenosis occurred in one case that underwent CAS.

Conclusion:
CAS and CEA are complementary approaches in treating symptomatic carotid stenosis even when performed by a single hybrid neurosurgeon as results obtained are commensurable to major studies like CREST.
Treatment of Benign C2 Tumors with Transoral Curettage and Posterior Instrumentation with Minimum 2-Year Follow-Up
Authors: Duan Ping G. , Zhu Xian J. , Zhong Yan L. , Li Xue L. , Wang Hui W. , Chou Dean , Yao Hao Q. 
Published: January 2022

Background:
Tumors of the axis (C2) are rare, which represents unique surgical challenges.

Aim:
To describe clinical outcomes and efficacy of transoral curettage and posterior instrumentation for treating C2 tumors, with a minimum 2-year follow-up.

Setting and Design:
This was a retrospective study conducted at a grade 3A hospital in China.

Materials and Methods:
From August 2015 to May 2017, patients diagnosed with benign C2 tumors were collected in the retrospective study. The Weinstein-Boriani-Biagini anatomic zone classification was used to characterize the tumors. The Japanese Orthopedic Association (JOA) score and the visual analog scale (VAS) pain scores were recorded pre and postoperatively. All patients were treated with posterior instrumentation and transoral curettage for tumor excision and iliac crest graft for arthrodesis.

Results:
Five patients were included in this report. The tumors involving C2 were all benign tumors. The JOA and VAS scores improved significantly at a 3-month follow-up, and the clinical symptoms were stable at the 12-month follow-up. Computed tomography (CT) scans at a 6-month follow-up showed solid arthrodesis in all patients. With a minimum 2-year follow-up, there was no implant loosening or tumor recurrence.

Conclusion:
The transoral curettage coupled with posterior instrumentation with iliac crest graft provides a reasonable option for the treatment of benign C2 tumors.
Prevalence of Aortic Plaques in Cryptogenic Ischemic Stroke
Authors: Arun K , Nambiar Poornima N , Kannath Santhosh Kumar , Sreedharan Sapna E , Sukumaran Sajith , Sarma Sankara , Sylaja P N 
Published: January 2022

Background and Purpose:
Limited data is available regarding the prevalence of aortic plaques in cryptogenic ischemic strokes and its correlation with risk factors.

Aim:
To determine the prevalence of aortic plaques in patients with cryptogenic ischemic stroke and its association with vascular risk factors and future vascular events.

Methodology:
Patients with cryptogenic ischemic stroke/TIA evaluated with CT angiogram (CTA) were recruited. Aortic plaque thickness ≥4 mm, plaque ulceration, protruding components, and complex plaques were considered significant.

Results:
Of the 1,767 patients, 229 (12.9%) had cryptogenic ischemic stroke/transient ischemic attack (TIA). Of them, 36 (15.7%) patients were detected to have significant aortic plaques. The significant plaque group had a higher mean age (68.3 ± 8.3 vs 54.4 ± 13.2, P = 0.0005) and were more likely to have risk factors like hypertension (P = 0.025), coronary artery disease (CAD)(P = 0.015), and peripheral vascular disease (POVD) (P = 0.029). Plaque morphology showed plaques of ≥4 mm, ulcerated plaques, protruding components, and complex plaques in 14.8%, 5.6%, 3.1%, and 6.5% patients, respectively, which are predominantly located in the aortic arch (44%). At 1 year combined endpoint of stroke, TIA, and vascular death was significantly higher in the significant plaque group (19.4% vs 6.2%, P = 0.016). Advanced age (adjusted OR-1.11, 95% CI-1.07–1.17, P = <0.001) was identified as an independent risk factor for significant aortic plaques on multivariate analysis.

Conclusions:
Aortic plaques are an under-recognized cause of cryptogenic stroke. The significant risk factors in aortic plaque group highlight the importance of aggressive risk factor control for secondary stroke prevention.
Clinical Profile and Diffusion Tensor Imaging in Patients of Subacute Sclerosing Pan Encephalitis
Authors: Saurabh Kumar , Singh Varun Kumar , Pathak Abhishek , Chaurasia Rameshwar Nath , Verma Ashish , Mishra Vijay Nath , Joshi Deepika , Kumar Anand 
Published: January 2022

Background:
Subacute Sclerosing Pan Encephalitis (SSPE) may present with atypical clinical features and lead to diagnostic dilemma. Conventional magnetic resonance imaging (MRI) may be normal in early stage of SSPE.

Objective:
The aim of this work was to study the demography, clinical profile including atypical features of SSPE patients, and the utility of diffusion tensor imaging (DTI) as an adjunctive diagnostic tool to the anti-measles antibody and conventional MRI.

Material and Methods:
Consecutive 25 patients of SSPE were included. Clinical details were recorded at baseline and 6 months follow-up. Anti-measles antibody in serum and CSF, CSF/Serum Quotient reference (CSQ ref), and radiological details including comparison of DTI between SSPE patients and controls were also noted.

Results:
Of 25 patients, 17 (68%) were male. The most common presenting feature at onset was myoclonus with or without falls (13, 52%). Atypical features such as seizure, hemiparesis, and visual problems were present in 28% patients. At 6 months, 9 patients had progressive course (6 expired), 10 were static, and 6 lost to follow-up. MRI was normal in 8 (32%) patients (stage 2/3- 7/1). On comparison between SSPE patients (N = 10) and control (N = 10) groups, fractional anisotropy (FA), and apparent diffusion coefficient (ADC) values were reduced and elevated, respectively, at most of the regions of interest with significant difference at many sites.

Conclusions:
A significant number of patients (28%) had atypical features at onset. DTI is an adjunctive tool which supplements the conventional MRI and increase diagnostic yield. It may be a future option to assess disease progression and treatment response.
Gender Differences and Impact of Autonomic Disturbance on Fatigue and Quality of Life in Parkinson's Disease
Authors: Bansal Nahush R , Paul Birinder S , Paul Gunchan , Singh Gagandeep 
Published: January 2022

Background:
Autonomic dysfunction can precede the onset of motor symptoms in Parkinson's disease and are very disabling, but often overlooked.

Objective:
This study was done to assess the presence of autonomic symptoms in PD; evaluate any gender differences and association of autonomic dysfunction with fatigue and quality of life.

Methods:
Demographic profile and disease characteristics of PD patients were assessed. Autonomic symptoms were evaluated by SCOPA-AUT, fatigue by FSS, and QOL with PDQ-39 in patient's vernacular language. Patients with SCOPA-AUT score ≥9 were considered as having autonomic impairment. Gender variation in the involvement of different domains were analyzed along with the risk factors for autonomic dysfunction.

Results:
Among 94 patients, 59 (63%) had autonomic dysfunction. All SCOPA domains showed significant impairment in PD. Nocturia (69.14%) and constipation (52.12%) constituted most frequent symptoms in our cohort. Mean urinary (7.89 vs. 6.05) and sexual (1.47 vs. 0.42) domain scores were significantly (P < 0.05) higher in males while cardiovascular dysfunction (0.81 vs. 1.64) was predominant in females. Patients with autonomic dysfunction had longer duration of disease (P = 0.033), severe disease (P = 0.0001) with higher UPDRS (P = 0.001). Autonomic symptoms correlated significantly (P < 0.0001) with Fatigue (r = 0.60) also. Patients with autonomic dysfunction had poor QOL (r = 0.67) and mobility, activities of daily living, emotional well-being, stigma, cognition, communication, and bodily-discomfort dimensions were worst affected (P < 0.05).

Conclusions:
There was a significant variation of autonomic symptoms with gender. Disease severity and duration were significant risk factors for autonomic dysfunction. Also there was a strong co-relation of fatigue and poor QOL with autonomic dysfunction.
Troponin Levels in COVID-19 Patients and its Correlation with the Severity of Disease and Clinical Outcomes
Authors: Shukla Vaibhav , Munagekar Advait 
Published: January 2022

Introduction:
The epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) has become a major health problem globally. The most common cardiac manifestation of COVID-19 infection is acute cardiac injury observed in patients even without any prior cardiac comorbidities. It is seen that several patients positive for COVID-19 showed increased concentrations of cardiac troponin, which lead to confusion in clinical interpretation. Our study was performed to observe the correlation between elevated troponin levels with clinical outcomes and the severity of COVID-19 disease.

Aim:
To observe the correlation between elevated troponin levels with clinical outcomes and severity of COVID-19 disease.

Materials and Methods:
This was a cross-sectional study among 100 reverse transcription–polymerase chain reaction positive COVID-19 patients with measurement of troponin-I on the 1st and 5th days of admission.

Results:
The greatest number of deaths were reported in patients with troponin-I ≥ 0.39 ng/ml. Higher Troponin levels were seen in the elderly population. Higher Troponin Levels were also seen in severe diseases.

Conclusion:
The present study showed that higher troponin levels were associated with increased mortality in COVID-19 patients and higher values were observed with severe disease.
Road Traffic Injuries among Schoolchildren from Rural and Urban Districts of South India
Authors: Babu Y. R. Manjunatha , Uthkarsh Pallavi Sarji , A Gangaboraiah 
Published: January 2022

Introduction:
Children are prone to road traffic injuries (RTIs) while commuting to school as pedestrians, bicyclists, motorcyclists, and occupants of vehicles. Understanding these injuries is crucial for planning injury prevention programs. There is not much data available regarding RTIs among schoolchildren during commute to schools in the urban and rural areas of South India, and the current study is an attempt to explore the burden of RTIs among schoolchildren.

Objectives:
The aim of the study was (1) to assess the magnitude of RTIs among rural and urban school children while commuting to schools and (2) to determine factors affecting RTIs among school children.

Materials and Methods:
A cross-sectional study was conducted in urban and rural districts of a state in South India, a pretested, semi-structured, self-administered questionnaire was used to collect data and analyzed using SPSS version 20.

Results:
Magnitude of RTIs reported was similar in urban and rural districts. Children going to Government (public schools) reported more compared to the ones going to private schools. Male children and those accompanying other schoolchildren during commute to schools reported more injuries.

Conclusion:
Nearly one-fourth of the schoolchildren from Bangalore urban and rural districts reported RTIs during the past 12 months.
A Comparative Study of Squash Smear Cytology Diagnosis and Radiological Diagnosis with Histopathology in Central Nervous System Lesions
Authors: Kumarguru B N , Santhipriya G , Kumar S Kranthi , Kumar R Ramesh , Ramaswamy A S , Janakiraman P 
Published: January 2022

Background:
Space occupying lesions (SOLs) of central nervous system (CNS) constitutes important cause of neurological morbidity and mortality. Squash cytology is technically a simple and rapid intraoperative diagnostic tool. Radiology is supportive of histopathological diagnosis.

Objectives:
To enumerate the histopathological patterns of various central nervous system (CNS) lesions, to correlate cytopathological diagnosis with histopathological diagnosis, and to correlate radiological diagnosis with histopathological diagnosis.

Materials and Methods:
It was a retrospective study of CNS lesion cases from January 2015 to August 2018. Cytological-histopathological concordance and radiological-histopathological concordance were calculated. Chi-square test was the statistical tool used for statistical analysis.

Results:
Histopathological diagnosis of 50 cases included neoplastic lesions (42 cases [84%]) and non-neoplastic lesions (8 cases [16%]). Correct diagnosis was achieved by squash cytology in 36 cases (72%) and radiological diagnosis in 25 cases (50%) by complete concordance. However, diagnostic accuracy of squash and radiology improved considerably by 90% and 76%, respectively, after applying partial concordance criteria. For the detection of neoplastic lesions, squash cytology had 98% and radiology had 80% diagnostic efficacy.

Conclusion:
Preoperative radiological investigation and intraoperative squash smear cytology are complementary to each other. A multidisciplinary approach is necessary for the management of patients.
Evaluation of hTERT Gene Expression and Chromosome 7 Copy Number Variation in Anal Squamous Intra-Epithelial Lesions
Authors: Arora Tanvi , Wadhwa Neelam , Aggarwal Divya , Pandhi Deepika , Diwaker Preeti , Arora Vinod K. 
Published: January 2022

Background:
Akin to cervical squamous intra-epithelial neoplasia (CIN), anal squamous intra-epithelial lesion (a-SIL) is attributed to persistent infection with high-risk human papilloma virus infection. Amplification of human telomerase reverse transcriptase (hTERT) gene and aneuploidy are known to correlate with CIN evolution. It is plausible that the underlying genetic events in a-SIL are similar. We conducted this cross-sectional analytical study with the objective of determining expression of hTERT gene expression and chromosome 7, as marker of cell ploidy in a-SIL.

Methods:
Conventional anal cytology was performed in 86 adult consenting subjects with history of receptive anal intercourse (RAI) and 4 controls without history of RAI. Cases with a-SIL and controls were subjected to fluorescent in-situ hybridization (FISH) to evaluate hTERT gene and chromosome 7 expression, as marker of cell ploidy. Results were expressed as number of abnormal nuclei (≥3 respective signals), maximum degree of amplification, mean signals/nucleus and proportion of cases showing abnormal nuclei.

Results:
Twenty cases showed a-SIL; with 15 atypical squamous cells of undetermined significance (ASCUS), 3 low grade squamous intra-epithelial lesion (LSIL) and 2 cases of high-risk cytology. Expression of both hTERT gene and chromosome 7 increased from controls to ASCUS to LSIL with concomitant increase in proportion of cases having abnormal hTERT gene and chromosome 7 expression.

Conclusions:
Positive association of hTERT gene with a-SIL suggests its possible role in evolution of anal squamous abnormalities. Increase in chromosome 7 also correlated positively with a-SIL. These findings corroborate the similarities between squamous carcinogenesis in CIN and a-SIL.
Papel de los estimulantes de eritropoyesis en la anemia neonatal
Authors: Roldán-Isaza Mariana , Roldan-Tabares Mabel Dahiana , Carvajal-Alzate Manuela , Morales-Quintero Natalia , Coronado-Magalhaes Gabriela , Martínez-Sanchez Lina María 
Published: January 2022

La anemia es una patología comúnmente encontrada en la población neonatal; es secundaria a una serie de factores de riesgo fisiológicos y no fisiológicos que contribuyen a su desarrollo. Entre sus variantes se encuentra la enfermedad hemolítica del feto y el recién nacido, la cual es considerada la causa más frecuente de anemia en dicha población. Se realizó la revisión bibliográfica en las bases de datos Medline, Science Direct y Lilacs hasta agosto de 2020. En la búsqueda y selección de los artículos se usaron los términos MeSH: anemia neonatal, eritroblastosis fetal y eritropoyetina. Para el tratamiento de dicha patología se dispone de a transfusión de glóbulos rojos y los agentes estimulantes de la eritropoyesis; el uso de eritropoyetina humana recombinante como parte del tratamiento ha sido ampliamente discutido y controvertido, no bstante, hay estudios que demuestran que su uso reduce la necesidad de transfusiones sanguíneas.
Transfusión intrauterina para el tratamiento del Hidrops fetal causado por anemia: Reporte de caso y revisión de la literatura
Authors: Hincapié-Porras Cristian , Rojas-Arias José Luis , Acuña-Osorio Edgar Mariano , Avellaneda-Salamanca Andrea Catalina , Pinto-Quiñonez Martha Lucia , Molina-Giraldo Saulo 
Published: January 2022

OBJETIVO
Reportar un caso de hidrops fetal no inmune causado por anemia. Además realizar una revisión de la literatura sobre anemia fetal asociada a hidrops.
METODOLOGÍA
Se presenta el caso de una gestante de 30 años G1P0, embarazo de 22 semanas. En valoración ecográfica se estableció diagnóstico sindromático de hidrops fetal no inmune causado por anemia. Requirio terapia fetal con múltiples transfusiones logrando resolución cuadro y nacimiento a término. Se realizó una búsqueda de la literatura en PUBMED, MEDLINE, EMBASE, Cochrane Library, incluyendo los términos Mesh: (non-immune fetal hydrops, middle cerebral artery, blood transfusion intrauterine).
RESULTADOS
Producto de la revisión no sistemática con la combinación de los términos Mesh anteriormente mencionados, se seleccionaron 37 artículos para la construcción del presente reporte. Se incluyeron artículos de revisión, protocolos, ensayos clínicos y artículos clásicos relacionados con el tema.
CONCLUSIÓN
El hidrops fetal no inmune causado por anemia fetal presenta alta mortalidad sin intervención adecuada. El conocimiento de esta patología permite realizar un diagnóstico oportuno, realizar un abordaje completo del binomio y seleccionar de manera adecuada los fetos candidatos a terapia in útero, impactando favorablemente, disminuyendo la morbimortalidad. El manejo de estas pacientes debe ser realizado en unidades materno-fetales con experiencia.