bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteristik pasien gangguan bipolar yang dirawat di RSUP Sanglah Denpasar periode April 2016 – Maret 2017
Authors: Sugiyanto Rose Widanti , Diniari Ni Ketut Sri , Ariani Ni Ketut Putri 
Published: December 2022

Background: Bipolar disorder is a brain disorder that changes the mood, though, energy and behavior. These abnormalities are implicated by manic, hypomanic, depression and mixed episodes. The incidence of bipolar disorder is not too high, ranging from 2% -4%. However, the incidence of bipolar disorder is more prolonged and more increase.Aim: This study aims to determine the characteristics of bipolar disorder treated in RSUP Sanglah Denpasar in the period April 2016 - March 2017.Method: This study is a descriptive retrospective design which is set at the General Hospital (RSUP) Sanglah Denpasar. Data obtained in the form of secondary data of patient's medical record on period April 2016 - March 2017. Data were analyzed by using SPSS program.Result and Conclusion: Of the 15 patients, the average age of the patient is 31-40 years (46.7%) with the first onset suffered on average 31-40 years old (40%), the most female (66.7% ), senior high school education (86.6%), unmarried marital status (53.3%), private employment (66.7%), bipolar type affective disorder bipolar episode now manic with psychotic symptoms (60%), none family history (80%), stressor of work problems (66.7%) with comorbid psychiatry (6.7%) and some with non-psychiatric comorbid (6.7%), substance abuse (26.7%), and most pharmacological therapy with anticonvulsant antipsychotic combination (20%) and non-pharmacological one by suggestive communication (40%) as well. Gangguan bipolar adalah kelainan otak yang ditandai dengan perubahan mood, pemikiran, energi dan tingkah laku. Kelainan ini ditandai dengan episode manik, hipomanik, depresi dan campuran. Dapat dikatakan insiden gangguan bipolar tidak tinggi, berkisar 2%-4%. Namun, angka kejadian gangguan bipolar terus meningkat dari tahun ke tahun.Tujuan: Untuk mengetahui karakteristik pasien gangguan bipolar yang dirawat di RSUP Sanglah Denpasar periode April 2016 – Maret 2017.Metode: Penelitian ini berupa desain deskritif restrospektif yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Data yang diperoleh berupa data sekunder rekam medis pasien periode April 2016 – Maret 2017. Data dianalisis dengan menggunakan program SPSS.Hasil dan Simpulan: Dari 15 pasien, rata-rata berusia 31- 40 tahun (46,7%) dengan onset pertama kali menenderita rata-rata berusia 31-40 tahun (40%), jenis kelamin terbanyak adalah perempuan (66,7%), pendidikan terakhir SMA (86,6%), status pernikahan belum menikah (53,3%), pekerjaan swasta (66,7%), tipe bipolar gangguan afektif bipolar episode kini manik dengan gejala psikotik (60%), tidak ada riwayat keluarga (80%), stressor masalah pekerjaan (66,7%) dengan komorbid psikiatri (6,7%) lalu sebagian dengan komorbid non psikiatri (6,7), penyalahgunaan zat (26,7%), dan terapi farmakologi terbanyak dengan kombinasi antipsikotik antikonvulsan (20%) serta terapi non farmakologi dengan pemberian komunikasi informasi edukasi (40%).
Hubungan konsumsi kopi hitam terhadap tekanan darah pada perokok dewasa
Authors: Naraswari Ni Made Sarah Manacika , Sutadarma I Wayan Gde , Dewi Ni Nyoman Ayu 
Published: December 2022

Background: Unhealthy lifestyles such as smoking and consuming coffee can affect blood pressure.Aim: The study aims to evaluate the association between black coffee consumption and hypertension.Method: This study design was cross-sectional with 93 participants. Data taken from questionnaire measurements and blood pressure measurements at a time.Results and conclusion: The results showed 79.6% had abnormal blood pressure and 20.4% had normal blood pressure. In this study male smoker workers who consumed black coffee were statistically related to blood pressure (p <0.05). Pola hidup yang tidak sehat seperti merokok dan mengkonsumsi kopi dapat mempengaruhi tekanan idarah.Tujuan: Untuk mengevaluasi hubungan konsumsi kopi hitam dan tekanan darah.Metode: Desain penelitian ini cross-sectional dengan 93 peserta sampel. Data yang diambil berasal dari pengukuran kuisioner dan pengukuran tekanan darah sewaktu.Hasil dan simpulan: Terdapat 79,6% sampel memiliki tekanan idarah tidak normal dan 20,4% memiliki tekanan darah normal. Dalam penelitian ini pekerja laki-laki perokok yang mengkonsumsi kopi hitam berhubungan secara statistik dengan tekanani darah (p < 0,05).
Hubungan kualitas hidup dan faktor resiko pada usia lanjut di wilayah kerja puskesmas Tampaksiring I Kabupaten Gianyar Bali 2015
Authors: Wikananda Gede 
Published: December 2022

Aging is a process characterized by a wide range of changes that occur in an individual, both mentally, socially, and physically. Along with increasing age, it is associated with changes in the quality of life of the individual. Unfortunately, these changes tend to be associated to a less good. It is associated with various factors, such as changes in socio-economic environment in the sense to stop working due to retirement, the inability to take part in society, loss of family and friends, the dependence of physical needs, a decrease in physical conditions, and lack of attention from people around, especially families in meeting the needs of physically and mentally the elderly. This condition can cause severe morbidity for the elderly if not handled properly, causing a bad impact on quality of life for the elderly which leads to increased morbidity and mortality. Based on these problems, the authors conducted a study to determine the level of quality of life for the elderly associated with various risk factors in the elderly in Puskesmas Tampaksiring I as a step advocacy in improving the programs of promotion and prevention in dealing with problems of the elderly in Puskesmas Tampaksiring I.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â This study is a cross - sectional descriptive study . Samples are elderly aged 60 years and older with a sample size of 90 people selected randomly in Tampaksiring Village and Village Sanding District Tampaksiring Gianyar regency using multistage random sampling technique. Data were obtained through interviews with respondents using a structured questionnaire.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â The results showed that the lack or poor quality of life associated with the age group > 70 years, male gender, low education levels, status is not married or a widow / widower, did not work, the level of monthly income is low, and the presence of > 2 chronic disease.
The role of the German scientist Karl Fuchs in the development of the Kazan Internal Medicine School
Authors: Khalfina T. N. , Shamsutdinova N. G. , Bombina L. K. , Abdulganieva D. I. 
Published: December 2022

The article is dedicated to Karl Fedorovich Fuchs, an outstanding doctor, scientist, and local historian, professor of the Department of Therapy, Pathology and Clinics, Dean of the Faculty of Medicine, Rector of the Imperial Kazan University. Being born in Germany, in the city of Herborn, he devoted his whole life to the benefit of Kazan and its inhabitants.The article describes the research, teaching and medical activities of K. Fuchs, his contribution to the development of clinical teaching and the development of the internal medicine school in Kazan. We described the range of his scientific interests and the influence of research on the development of medicine in Kazan in the 19th century. Much attention is paid to the personality traits of K. F. Fuchs, an integral part of the doctor and teacher, which inspire students for further development.
Prevention of induced nausea and vomiting in patients with malignant blood disorders. Experience of using netupitant/palonosetron (Akynzeo)
Authors: Ryabukhina Yu. E. , Zeynalova P. A. , Timofeeva O. L. , Abbasbeyli F. M. 
Published: December 2022

Supporting therapy is a necessary component of successful antitumor treatment in patients with both solid tumors and malignant blood disorders. Adherence to administration protocol for antiemetic drugs aimed at prevention of induced gastrointestinal complications (nausea and vomiting), allows to improve patients' quality of life and treatment compliance. Development of a combination antiemetic drug (netupitant/palonosetron) simultaneously affecting 2 main mechanisms of nausea and vomiting as well as its easy administration allowed to significantly improve control of these complications in patients with solid tumors and patients with malignant blood disorders.We present a literature review on the effectiveness of netupitant/palonosetron and describe our own experience of using this antiemetic drug for prevention of chemotherapy-induced nausea and vomiting.
Impact of QR-Codes as a Disruptive Technology During the Covid-19 Contagion
Authors: Mookerjee Joydeep , Chattopadhyay Subir , Ahmed Tusar , Addepalli Lavanya 
Published: December 2022

Introduction In the world economy, QR codes became very popular, and their prominence is expanding rapidly. The QR-codes look a bit like barcodes, but are made up of square patterns. As businesses are increasingly embracing these technologies, QR codes are becoming more popular, QR code readers are being integrated into smartphones. Apple released iOS 11 to search QR codes using the smartphone camera back in 2017 which is now a game-changing marketing strategy for businesses and retailers.
Objective: The objective of the paper is to conduct an extensive theoretical review on the growth of QR codes in the digital era and QR codes' reach as contactless payment solutions.
Methodology: A bibliometric review by refereeing quality articles published in highly ranked journal.
Conclusion: When the QR code reader was integrated into the new Android smartphone camera, it proved to be a key differentiator. Following the global COVID-19 contagion, there has been a nudge for contactless activities and remote resource allocation, such as online work, payments and online classes among others. QR-codes have seen a spectacular increase in usage across all aspects of life.
Estimating Coseismic Deformation of Southwestern Puerto Rico from the 7 January 2020 Mw 6.4 Earthquake: Constraints from Campaign and Continuous GPS
Authors: López-Venegas Alberto M. , Mattioli Glen S. , Solares-Colón Margarita , Mencin David , Jansma Pamela E. 
Published: December 2022

ABSTRACTThe Puerto Rico–Virgin Islands (PRVI) block lies within the Northern Caribbean Plate Boundary Zone—a zone accommodating stresses between the larger North America and Caribbean plates. Data from Global Positioning System (GPS) sites throughout the PRVI block have been used to confirm the existence of a distinct microblock in the southwest. It is no coincidence that this portion of the PRVI block is the epicentral region of the 7 January 2020 Mw 6.4 earthquake and the ensuing seismic sequence. Prior to the mainshock, the southwestern Puerto Rico (SWPR) region exhibited most of the onland seismic activity. The 2020–2021 SWPR earthquake seismic sequence has been characterized by having an atypical aftershock decay distribution occurring along multiple faults. As a result, fault parameters of the 7 January 2020 mainshock have been poorly defined by conventional seismic methods. Here, we present results from campaign and continuous GPS sites in SWPR, and compare GPS-derived displacements to those computed from the U.S. Geological Survey National Earthquake Information Center (NEIC) focal mechanism. We conclude that irrespective of which nodal plane is used, the observed coseismic displacements from GPS differ from those predicted using a simple elastic model and the NEIC focal mechanism. We infer based on these observations that the complex mainshock rupture resulted in a suboptimal double-couple solution.
Seismic Monitoring of Machinery through Noise Interferometry of Distributed Acoustic Sensing
Authors: Xiao Zhuo , Li Chao , Zhou Yong , Xu Min , Yang Huayong , Zhang Yayun , Di Huizhe , Wang Peifeng , Lin Zehui , Zhang Peng , Zhu Sheng 
Published: December 2022

AbstractApplication of distributed acoustic sensing (DAS) in seismic studies has benefited from its high-density acquisition, environmental adaptation, and low-cost deployment. Nevertheless, the great potential of such observations in seismic research across scales is far from explicit. To test the feasibility of DAS for small-scale seismic monitoring in the urban city, we conducted a one-week field experiment with three ∼72 m long fiber-optic cables, and eight seismometers at the campus of southern marine science and engineering Guangdong laboratory (Guangzhou). Stable high-frequency (2–8 Hz) noise correlation functions (NCFs) were successfully retrieved between DAS channels from continuous in situ noise recording. The observed NCFs are highly asymmetrical, indicating the nonuniform distribution of the noise sources. Beamforming analysis of the seismic data demonstrates that the noise sources are stable daily with consistent direction and slowness. Temporal variation of the NCFs shows that the observed stable signals emerge simultaneously with the machinery operating time of the campus. NCF modeling with spatially varying source spectra reveals that a localized source in the nearby office building fitted the observations well. Accordingly, ground vibration of operating machinery is suggested to account for the temporal and spatial features retrieved from the observed NCFs. Our study demonstrates that DAS has great potential in high-resolution source localization and characterization, as well as temporal monitoring (∼hours) using urban anthropogenic seismic sources.
Manajemen Pembelajaran Di Pesantren Miftahul Ulum Bettet Pamekasan Pada Masa Pandemi Covid-19
Authors: Subhan Moh. , Ahmad  
Published: December 2022

Abstrak :
Masa pandemi Covid-19 berdampak pada semua aspek kehidupan manusia tidak terkecuali pada ranah pendidikan. Semua satuan pendidikan pada umumnya melaksanakank pembelajaran secara daring guna menghindari tersebarnya virus tersebut. Namun demikian, Pondok Pesantren Miftahul Ulum Bettet Pamekasan tetap melakukan pembelajaran secara luring namun tetap memberlakukan protokol kesehatan secara katat. Kajian ini berupaya untuk mengungkap manajemen pembelajaran yang diterapkan oleh pondok tersebut selama masa pandemi Covid-19. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan jenis studi kasus. Hasil penelitan ini menunjukkan bahwa manajemen yang dilakukan mencakup 3 hal; 1) perencanaan yang berkaitan dengan pemenuhan prokotol kesehatan dan perencanaan yang berkenaan dengan mekanisme proses pembelajaran yang termuat dalam RPP dan silabus; 2) pelaksanaan pembelajaran dilakukan secara tatap muka dengan tetap memperhatikan protocol kesehata.Pelaksanaan pembelajaran mencngkup tiga tahapan yaitu pendahuluan, kegiatan inti, dan penutup; 3) evaluasi dilakukan secara berkesinambungan pada akhir pembelajran guna melihat tingkat efektifitas pembelajaran. Di samping itu, evaluasi pembelajaran juga dilakukan dengan model evaluasi sumatif dan formatif.
MOLECULAR MECHANISMS DEFINING APPLICATION OF GLYCINE AND ZINC COMBINATIONIN CORRECTION OF STRESS AND ANXIETY MAIN MANIFESTATIONS
Authors: Shishkova V. N. , Nartsissov Y. R. , Titova V. Y. , Sheshegova E. V. 
Published: December 2022

The aim of the work was to carry out a systematic analysis of the molecular mechanisms that determine the possibility of a combined use of amino acid glycine and zinc compounds for the treatment of patients with manifestations of stress and anxiety.Materials and methods. Information retrieval (Scopus, PubMed) and library (eLibrary) databases were used as research tools. In some cases, the ResearchGate application was applied for a semantic search. The analysis and generalization of references was carried out on the research topic, covering the period from 2000 to the present time.Results. It has been shown that amino acid glycine, along with gamma-aminobutyric acid (GABA), is a key neurotransmitter that regulates physiological inhibition processes in the central nervous system (CNS) by increasing transmembrane conductance in specific pentameric ligand-gated ion channels. The introduction of zinc ions can potentiate the opening of these receptors by increasing their affinity for glycine, resulting in an inhibitory processes increase in CNS neurons. The replenishment of the glycine and zinc combined deficiency is an important element in the correction of a post-stress dysfunction of the central nervous system. A balanced intake of zinc and glycine is essential for most people who experience daily effects of multiple stresses and anxiety. This combination is especially useful for the people experiencing a state of chronic psycho-emotional stress and maladaptation, including those who have a difficulty in falling asleep.Conclusion. A balanced maintenance of the zinc and glycine concentration in the body of a healthy person leads to the development of a stable anti-anxiety effect, which is accompanied by the normalization of the sleep-wake rhythm, which makes it possible to have a good rest without any loss of working efficiency after waking up.
В6.А-DYSFPRMD/GENEJ MICE AS A GENETIC MODEL OF DYSFERLINOPATHY
Authors: Korokin M. V. , Kuzubova E. V. , Radchenko A. I. , Deev R. V. , Yakovlev I. A. , Deikin A. V. , Zhunusov N. S. , Krayushkina A. M. , Pokrovsky V. M. , Puchenkova O. A. , Chaprov K. D. , Ekimova N. V. , Bardakov S. N. , Chernova O. N. , Emelin A. M. , Limaev I. S. 
Published: December 2022

The aim of the work was behavioral and pathomorphological phenotyping of the mice knockout for the DYSF gene, which plays an important role in the development and progression of dysferlinopathy.Materials and methods. A B6.A-Dysfprmd/GeneJ (Bla/J) mice subline was used in the work. During the study, a muscle activity was determined basing on the following tests: “Inverted grid”, “Grip strength”, “Wire Hanging”, “Weight-loaded swimming”, Vertical Pole”. Histological and immunofluorescent examinations of skeletal muscles (m. gastrocnemius, m. tibialis) were performed. The presence and distribution of the dysferlin protein was assessed, and general histological changes in the skeletal muscle characteristics of mice at the age of 12 and 24 weeks, were described. A morphometric analysis with the determination of the following parameters was performed: the proportion of necrotic muscle fibers; the proportion of fibers with centrally located nuclei; the mean muscle fiber diameter.Results. The “Grip strength” test and the “Weight-loaded swimming” test revealed a decrease in the strength of the forelimbs and endurance in the studied mice of the Bla/J subline compared to the control line. The safety of physical performance was checked using the “Wire Hanging” test and the “Vertical Pole” test, which showed a statistically significant difference between the studied mice and control. The coordination of movements and muscle strength of the limbs examined in the “Inverted Grid” test did not change in these age marks. Decreased grip strength of the forelimbs, decreased physical endurance with age, reflects the progression of the underlying muscular disease. Histological methods in the skeletal muscles revealed signs of a myopathic damage pattern: necrotic muscle fibers, moderate lympho-macrophage infiltration, an increase in the proportion of fibers with centrally located nuclei, and an increase in the average fiber diameter compared to the control. The dysferlin protein was not found out in the muscle tissues.Conclusion. Taking into account the results of the tests performed, it was shown that the absence of Dysf-/- gene expressionin Bla/J subline mice led to muscular dystrophy with the onset of the development of phenotypic disease manifestations at the age of 12 weeks and their peak at 24 weeks. Histopathological phenotypic manifestations of the disease are generally nonspecific and corresponded to the data of intravital pathoanatomical examination in diferlinopathy patients. The mice of the studied subline Bla/J are a representative model of dysferlinopathy and can be used to evaluate new therapeutic agents for the treatment of this disease.
Identification of The Same and The Major Components in Zingiber amaricans BL., Zingiber aromaticum Val. and Zingiber zerumbet (L.) Smith Rhizomes Essential Oils from Jumapolo Karanganyar Central Java Indonesia
Authors: Ariani Sri Retno Dwi , Septiana Nurul , Falentina Septa 
Published: December 2022

<p>The aim of this research was to know about the same and the major essential oils components in bitter ginger (<em>Zingiber amaricans</em> BL.), fragrant ginger (<em>Zingiber aromaticum</em> Val.) and shampoo ginger (<em>Zingiber zerumbet</em> (L.) Smith) rhizomes from Karanganyar Central Java Indonesia. The steps of this research were prepared samples, extracted with steam destillation methode and identificated essential oil components of samples with Gass Chromatography-Mass Spectrophotometry (GC-MS) method. The same components between <em>Z. amaricans</em> BL.,<em> </em><em>Z. aromaticum</em> Val., and <em>Z. zerumbet</em> (L.) Smith were zerumbone, α-humulene, β-selinene dan (-)-caryophyllene oxide. The mayor constituent in <em>Z. amaricans</em> BL., <em>Z. aromaticum</em> Val., and <em>Z. zerumbet</em> (L.) Smith oils were zerumbone. <em>Z. zerumbet</em> (L.) Smith oil presented the highest quantity of zerumbone (77.62%).</p>
Antioxidant Potency of Cassumunin A-C Compounds from Bangle Rhizome (Zingiber cassumunar) by Molecular Docking on Human ROS-1 kinase Receptors
Authors: Utami Dwi , Solikah Wahyu Yuliana , Mahfudh Nurkhasanah 
Published: December 2022

<p>Antioxidants play an role in human health by fighting oxidative stress and preventing chronic disease. Nowadays, molecular docking is used Bangle rhizome (<em>Zingiber cassumunar</em>) has a derivative of curcuminoid, cassumunin A, cassumunin B, and cassumunin C. This study was designed to determine the value of binding affinities between cassumunins ligands on human ROS1 kinase receptors, related to their antioxidant activity with ascorbic acid and tocopherol. One set of computational programs is Autodock Tools, Biovia Discovery Studio, and Command Prompt has prepared. These docking results presented the binding affinity values of cassumunin A, cassumunin B, cassumunin C, ascorbic acid, and tocopherol were -9.4 kcal/mol, -9.7 kcal/mol, -9.0 kcal/mol, -5.2 kcal/mol, and -8.1 kcal/mol respectively. RMSD value for the five ligands was ≤ 2Å, showed the validity of the docking results. Cassumunin A-C compound higher affinity compared to ascorbic acid and tocopherol. Based on this computational study, cassumunin A-C the potential compounds to be developed as potent antioxidant agents from natural resources.</p>