bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerous independent gains of daily torpor and hibernation across endotherms, linked with adaptation to diverse environments
Authors: Kontopoulos Dimitrios‐Georgios , Levesque Danielle L. , Hiller Michael 
Published: January 2025

Abstract

Many endotherms from diverse taxonomic groups can respond to environmental changes through torpor, that is, by greatly reducing their energy expenditure for up to 24 hours (daily torpor) or longer (hibernation). We currently have a poor understanding of how torpor evolved across endotherms and its associations with physiological traits and ecological factors.

To fill this gap, we thoroughly examine the evolutionary patterns of torpor and its links with 21 key physiological and ecological variables across 1338 extant endotherms.

We find that daily torpor and hibernation are parts of an evolutionary torpor continuum, and that there are several, albeit weak, associations between torpor and species' physiological or environmental characteristics. Furthermore, we show that early endotherm ancestors likely did not hibernate and that this trait evolved multiple times in independent lineages.

Overall, our results suggest that the remarkable variation in torpor patterns across extant endotherms cannot solely be attributed to environmental niches, but partly arises from independent gains of daily torpor and hibernation in various clades.

Read the free Plain Language Summary for this article on the Journal blog.
Couple therapy and systemic interventions for adult‐focused problems: The evidence base
Authors: Carr Alan 
Published: January 2025

AbstractThis twenty‐fifth anniversary review updates previous similar papers published in JFT in 2000, 2009, 2014 and 2019. It presents evidence from meta‐analyses, systematic reviews and controlled trials for the effectiveness of couple therapy and systemic interventions for adults with a range or relationship and mental physical health problems. The evidence supports the effectiveness of systemic interventions, either alone or as part of multimodal programmes, for relationship distress, psychosexual problems, intimate partner violence, anxiety and mood disorders, alcohol problems, schizophrenia and adjustment to chronic physical illness. Systemic interventions are as effective as evidenced‐based individual psychotherapeutic interventions for all of these problems, and more effective than individual therapy for some, including for relationship distress, situational intimate partner violence and delaying relapse in schizophrenia.
Challenges and opportunities for data integration to improve estimation of migratory connectivity
Authors: Hostetler Jeffrey A. , Cohen Emily B. , Bossu Christen M. , Scarpignato Amy L. , Ruegg Kristen , Contina Andrea , Rushing Clark S. , Hallworth Michael T. 
Published: January 2025

Abstract

Understanding migratory connectivity, or the linkage of populations between seasons, is critical for effective conservation and management of migratory wildlife. A growing number of tools are available for understanding where migratory individuals and populations occur throughout the annual cycle. Integration of the diverse measures of migratory movements can help elucidate migratory connectivity patterns with methodology that accounts for differences in sampling design, directionality, effort, precision and bias inherent to each data type.

The R package MigConnectivity was developed to estimate population‐specific connectivity and the range‐wide strength of those connections. New functions allow users to integrate intrinsic markers, tracking and long‐distance reencounter data, collected from the same or different individuals, to estimate population‐specific transition probabilities (estTransition) and the range‐wide strength of those transition probabilities (estStrength). We used simulation and real‐world case studies to explore the challenges and limitations of data integration based on data from three migratory bird species, Painted Bunting (Passerina ciris), Yellow Warbler (Setophaga petechia) and Bald Eagle (Haliaeetus leucocephalus), two of which had bidirectional data.

We found data integration is useful for quantifying migratory connectivity, as single data sources are less likely to be available across the species range. Furthermore, accurate strength estimates can be obtained from either breeding‐to‐nonbreeding or nonbreeding‐to‐breeding data. For bidirectional data, integration can lead to more accurate estimates when data are available from all regions in at least one season.

The ability to conduct combined analyses that account for the unique limitations and biases of each data type is a promising possibility for overcoming the challenge of range‐wide coverage that has been hard to achieve using single data types. The best‐case scenario for data integration is to have data from all regions, especially if the question is range‐wide or data are bidirectional. Multiple data types on animal movements are becoming increasingly available and integration of these growing datasets will lead to a better understanding of the full annual cycle of migratory animals.
Visual function and vehicle driving performance under the effects of cannabidiol: A randomized cross‐over experiment
Authors: Ortiz‐Peregrina Sonia , Martino Francesco , Casares‐López Miriam , Granados‐Delgado Pilar , Anera Rosario G. , Castro Torres José J. 
Published: January 2025

AbstractAimsThis study aimed to determine the effect of vaporized cannabidiol (CBD) on visual function and vehicle driving performance, given the growing popularity of CBD use worldwide.DesignRandomized, double‐blind, placebo‐controlled cross‐over experimental study.SettingLaboratory of Vision Sciences and Applications, University of Granada, Spain.ParticipantsThirty participants were recruited through advertisements placed in the local newspaper and distributed among the university community. They had a mean age of 26.2 (6.2) years, and 70% were male. All of them were occasional users of CBD or cannabis, and held valid driving licenses.InterventionsThree experimental sessions, conducted one week apart, in which a placebo, 15% CBD (16 mg) or 30% CBD (32 mg) was vaporized.MeasurementsThe primary endpoint for driving performance was the overall driving performance score (ODPS). Secondary outcomes included visual function variables such as static and dynamic visual acuity, stereoacuity, contrast sensitivity, motion detection and other driving performance parameters such as mean speed, lateral vehicle control or reaction time.FindingsComparisons revealed no statistically significant changes in ODPS after vaporizing CBD at 15% or 30% compared with the placebo (χ2 = 0.479; P = 0.787). Visual function remained largely unchanged, with only a statistically significant decrease in motion detection (χ2 = 7.980; P = 0.018). Similarly, no statistically significant differences were found in driving performance secondary outcomes, such as the standard deviation of lateral lane position (χ2 = 0.068; P = 0.966), distance travelled outside the lane (χ2 = 2.530; P = 0.282), reaction time (χ2 = 1.000; P = 0.607), or collisions (χ2 = 0.987; P = 0.610). Additionally, correlations between ODPS and visual function did not yield statistically significant results.ConclusionsConsumption of vaporized cannabidiol in 16 mg and 32 mg doses does not appear to affect simulated vehicle driving performance and visual function.
Global Burden of Gallbladder Cancer Attributable to Modifiable Risk Factors
Authors: Piovani Daniele , Nikolopoulos Georgios K. , Figlioli Gisella , Tsantes Andreas G. , Bonovas Stefanos 
Published: January 2025

ABSTRACTGallbladder cancer (GBC) is a highly lethal and often overlooked malignancy increasingly affecting young adults. This study quantified the global proportion of GBC cases attributable to 10 key modifiable risk factors, employing Monte Carlo simulations and estimates from field‐wide systematic review and meta‐analysis. Approximately three‐quarters of global GBC cases are attributable to key modifiable factors (74.6%; 95% uncertainty interval, 63.7–83.7), with a slightly higher share observed in females. Central obesity (29.7%; 8.7–49.5), gallstones (27.9%; 16.8–40.7), and physical inactivity (20.5%; 7.4–34.1) were identified as the leading contributors. Most GBC cases are preventable, with a large share linked to metabolic health conditions.
Resurrected analysis: Navigating time between two environmental projects in Finland
Authors: Garson Katja 
Published: January 2025

AbstractThis paper considers the ways in which research projects linger beyond their ‘official’ endings, and how to deal with this. Building on conversations in human geography and related disciplines on slow research, performed endings, and the practical and socio‐political complexities of data storage and analysis over time, I relate some experiences with my research on the Finnish Saimaa Ringed Seal, which resurfaced years later via a new project. Should I re‐engage or leave it as a discrete period of previous work? An end to funding or finishing the write‐up does not necessarily sever the connection between a researcher and their data. I argue that social research can be an ongoing, slow, and personal process. My aim is to encourage both new and more experienced researchers to reflect on how we think about data and analysis when projects may live on in our minds or in boxes in a cupboard.
Characterization of volatile compound profile in Mongolian traditional fermented mare's milk, as Airag
Authors: Ganzorig Oyundelger , Batdorj Batjargal , Satomi Ishii 
Published: January 2025

AbstractWe aimed to evaluate the volatile compounds profile in traditional airag samples collected from two regions, including Bulgan and Uvurkhangai provinces, whereas famous airag‐making areas in Mongolia. The volatile compounds of airag were investigated by the GC–MS method. A total of 95 kinds of volatile compounds were detected, and these were classified into 6 different classes: 14 acids, 14 alcohols, 16 aldehydes, 19 esters, 9 ketones, and 23 aliphatic hydrocarbons. Among them, acetic acid, 2‐methyl propionic acid, isoamyl lactic acid, 2‐methyl butanoic acid, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, n‐decanoic acid, 1‐propanol, 3‐methyl 1‐butanol, phenyl ethyl alcohol, acetaldehyde, acetoin, ethyl acetate, ethyl hexanoate, ethyl caprylate, ethyl decanoate, ethyl 9‐decanoate, and ethyl laurate had a high concentration in airag samples. It may explain that acids, alcohols, and esters mainly influence the taste and aroma of airag, and aldehydes change depending on their fermentation time. We also found that Bulgan provinces` samples contained 20 types of aliphatic hydrocarbons, which may relate to the vegetation and fermentation process. The formation of sensory characteristics in airag is a complex and unclear process because it affects many factors. Our findings provide essential guidance on the composition of volatile compounds in Mongol airag.
Decoding Normal‐Fault Controlled Trends in Stratigraphic Grain Size: Examples From the Kerinitis Gilbert‐Type Delta, Greece
Authors: Rezwan Nahin , Whittaker Alexander C. , McLeod Jonah S. , Hook Joel , Castelltort Sébastien , Schlunegger Fritz 
Published: January 2025

ABSTRACTStratigraphy and its associated grain size preserve a record of the dynamic behaviour of source‐to‐sink systems over time. Sediment supply and available accommodation space primarily control downstream grain‐size fining preserved in stratigraphy. In principle, these grain‐size trends can be inverted to quantify temporal and spatial variation in these driving forces. Here, we illustrate how grain size and stratigraphic thickness can be used to quantify fault growth and interaction using the early‐mid Pleistocene Pirgaki‐Mermoussia (P‐M) fault, Gulf of Corinth, Greece, as a natural laboratory. A 2.5 km long exposed cliff section of the uplifted Kerinitis Gilbert‐type delta, which lies in the hanging wall of the P‐M fault, was selected for study. In the field, we traced out stratigraphic units in the lower part of the Kerintis delta, which are bounded by flooding surfaces, and measured their thickness to reconstruct hanging wall subsidence. We collected down‐system grain‐size data at 31 measurement sites using the Wolman point count method. Our results show the observed grain‐size fining rate increase from 11 to 17 mm.km−1 for the lower delta deposits over a timescale of up to 120 kyr. Using a self‐similarity‐based grain‐size fining model and considering a minimum increase in accommodation generation from 0.6 to 1 mm year−1 over this period, we reconstruct an increase in delta sediment supply from ca. 170 to 460 m3 year−1. The integration of stratigraphic thickness measurements with grain‐size fining trends enables quantitative reconstruction of temporal variations in fault‐driven accommodation space and sediment supply, thereby demonstrating fault slip rate evolution. We show an increase in the P‐M fault slip rate during its early history from 1 to 2 mm year−1, reflecting early interaction of the P‐M fault segments over ca. 120 kyr. Reconstructed catchment‐averaged erosion rates are ca. 20% of the footwall uplift, implying a transient response of the landscape to the P‐M fault growth. These analyses demonstrate how grain‐size data from a well‐constrained geological example can be used to reconstruct landscape dynamics quantitatively in fault‐controlled sedimentary systems with high temporal and spatial resolution.
European multicentre analysis of the implementation of robotic complete mesocolic excision for right‐sided colon tumours
Authors: Van Eetvelde Ellen , Duhoky Rauand , Piozzi Guglielmo Niccolò , Perez Daniel , Jacobs‐Tulleneers‐Thevissen Daniel , Khan Jim , Bianchi Paolo Pietro , Ruiz Marcos Gomez 
Published: January 2025

AbstractAimComplete mesocolic excision (CME) is an oncologically driven technique for treating right colon cancer. While laparoscopic CME is technically demanding and has been associated with more complications, the robotic approach might reduce morbidity. The aim of this study was to assess the safety of stepwise implementation of robotic CME.MethodA multicentre retrospective analysis of prospectively collected data on robotic right colectomy was performed at five European tertiary centres. Patients were classified for type of surgery: R‐RHC (standard right colectomy), R‐impCME (learning cases towards robotic CME defined as R‐RHC with one but not all the hallmarks of CME) or R‐CME (robotic CME). Primary outcomes were overall and severe 30‐day complication rates before and after propensity score matching (PSM) analysis.ResultsFive hundred and fifty‐one consecutive patients undergoing robotic surgery for (pre)malignant lesions of the right colon between 2010 and 2020 were included: R‐RHC (n = 101), R‐impCME (n = 135) and R‐CME (n = 315). Baseline characteristics differed for American Society of Anesthesiologists score (p = 0.0012) and preoperative diagnosis of adenocarcinoma (p < 0.001). Procedure time increased by surgical complexity (p < 0.001). Vascular event rates did not differ, with no superior mesenteric vein injuries. Conversion, complication and anastomotic leak rates, time to flatus/soft diet and length of stay (LOS) did not differ. While R‐RHC was performed for a lower rate of malignancies (p < 0.001), lymph node yield was significantly higher in R‐CME (p < 0.001). After PSM, analyses on 186 patients documented no differences in overall and severe 30‐day complication rate, conversion rate, LOS or 30‐day mortality.ConclusionR‐CME can be implemented without increasing the overall or 30‐day severe complication rate.
Risk Factors Analysis of Cutaneous Adverse Drug Reactions Caused by Targeted Therapy and Immunotherapy Drugs for Oncology and Establishment of a Prediction Model
Authors: Zhang Zimin , Zhu Mingyang , Jiang Weiwei 
Published: January 2025

ABSTRACTTargeted therapy and immunotherapy drugs for oncology have greater efficacy and tolerability than cytotoxic chemotherapeutic drugs. However, the cutaneous adverse drug reactions associated with these newer therapies are more common and remain poorly predicted. An effective prediction model is urgently needed and essential. This retrospective study included 1052 patients, divided into train set, test set, and external validation set. As a data‐driven study, a total of 76 variables were collected. Univariate logistic analysis, least absolute shrinkage and selection operator regression, and stepwise logistic regression were utilized for feature screening. Finally, nine machine‐learning models were constructed and compared, and grid search was performed to adjust the parameters. Model performance was evaluated using calibration curve and the area under the receiver operating characteristic curve (AUROC). Nine risk factors were eventually identified: age, treatment modality, cancer types, history of allergies, age‐corrected Charlson comorbidity index, percentage of eosinophils, absolute number of monocytes, Eastern Cooperative Oncology Group Performance Status, and C‐reactive protein. Among the models, the logistic model performed best, demonstrating strong performance in test set (AUROC = 0.734) and external validation set (AUROC = 0.817). This study identified nine significant risk factors and developed a nomogram prediction model. These findings have important implications for optimizing therapeutic efficacy and maintaining the quality of life of patients from the perspective of managing cutaneous adverse drug reactions.Trial Registration: ChiCTR2400088422
Incremental Role of Cardiac CT Angiography in the Assessment of Left Ventricular Diastolic Function in Patients With Suspected Coronary Artery Disease With Normal Ejection Fraction: A Comparison With Transthoracic Echocardiography
Authors: Kumar Amy Fiona Suresh , Ojha Vineeta , Veettil Sreelal Thazhathu , Mantoo Mohsin , Singh Damandeep , Pandey Niraj Nirmal , Jagia Priya , Yadav Satyavir , Kumar Sanjeev 
Published: January 2025

ABSTRACTObjectiveDiastolic dysfunction (DD) is defined as impaired left ventricular (LV) relaxation, caused by structural or functional heart diseases. We sought to assess the role of cardiac CT angiography (CCTA) as a tool to evaluate LV DD in patients with normal EF using the diastolic expansion index (DEI), as compared to transthoracic echocardiography (TTE) as the gold standard.MethodsPatients presenting with atypical chest pain with suspected coronary artery disease (CAD) and having a normal LV ejection fraction on TTE underwent CCTA using a dual source CT scanner. Assessment of diastolic function on CCTA was done using DEI, and it was compared with TTE‐derived diastolic function as per standard ASE/EACVI guidelines. DEI was measured using a dedicated postprocessing software (Syngo.via VB20, Siemens Healthcare, Germany) and was calculated as a ratio of maximum LV volume (in LV end‐diastole) to maximum left atrial (LA) volume (in LV end‐systole), with the mean value of readings from three independent readers taken for each calculation.ResultsThe study included 141 patients (60 male; mean age 50.82 ± 10.20 years; mean heart rate 84.90 ± 16.15 beats per minute). CCTA‐derived mean indexed LA volumes correlated well with TTE measurements but were larger when compared to TTE (r = 0.53, p < 0.0001). A progressive increase in LA volume index was noted with worsening DD grades. Excellent inter‐observer correlation was seen between the three observers for LA volume index (intra‐class correlation coefficient: 0.999 [95% CI: 0.999–0.999] and for DEI 0.996 [95% CI: 0.995–0.997]). A normal LV diastolic function was predicted by a DEI > 1.57 with a specificity and sensitivity of 88.3% and 81.6%, respectively (area under curve (AUC)‐0.87), whereas an abnormal LV diastolic function was predicted by DEI <1.46 with a specificity and sensitivity of 84.8% and 62.5%, respectively (AUC‐0.848). There was a significant correlation between the presence of obstructive CAD and an increase in calcium score with DD grade (p = 0.006 and 0.001, respectively).ConclusionCCTA‐derived DEI is a reliable metric for assessing LV diastolic dysfunction in patients with suspected CAD with normal ejection fraction. The presence of obstructive CAD and an increase in calcium score correlated with worsening DD grade.
Cerebrotendinous xanthomatosis: A complex interplay between a clinically and genetically heterogeneous condition
Authors: O'Keefe Emily , Kiernan Matthew , Huynh William 
Published: January 2025

AbstractBackground and PurposeCerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disease characterized by abnormal bile acid synthesis. It often presents with systemic and neurological manifestations; however, atypical presentations can lead to significant diagnostic challenges. This case report highlights the diagnostic complexities and management considerations in a patient with an uncommon presentation of CTX.MethodsWe present a patient with a 25‐year history of spastic paraparesis, initially suggestive of hereditary spastic paraplegia (HSP), ultimately diagnosed with CTX associated with a novel CYP27A1 variant of uncertain significance (VUS).ResultsA 53‐year‐old Greek woman presented with a 25‐year history of slowly progressive spastic paraparesis. Initial investigations were largely unremarkable, leading to a presumptive diagnosis of a hereditary spastic paraplegia (HSP)‐like syndrome. After 5 years of slow disease progression, the patient developed right ankle swelling. MRI revealed significant enlargement of the Achilles tendon, suggestive of xanthoma infiltration. Subsequent genetic testing identified a homozygous variant of uncertain significance (VUS) in the CYP27A1 gene. Biochemical analyses revealed elevated cholestanol levels and cholestanepentol glucuronide in urine, confirming the diagnosis of CTX. Treatment with chenodeoxycholic acid stabilized her condition over 3 years, but advanced disease limited efficacy in improving disability.ConclusionThis case highlights the diagnostic challenges associated with CTX, stemming from its relative rarity and significant clinical heterogeneity. It emphasizes the importance of a comprehensive approach combining clinical suspicion, imaging, genetic testing and biochemical analyses for accurate diagnosis, interpretation of VUS and management of rare conditions like CTX.
Diverse perspectives: Empirical research trends and demographics in family court review the past 25 years
Authors: Harris‐Britt April , Siotia Suchika , Walk Kelly 
Published: January 2025

AbstractFamily Court Review (FCR) stands as a premier, peer‐reviewed journal in family law practice, providing a platform for practical, theoretical, and empirical articles. Anchored in core values of interdisciplinary collaboration and a commitment to the well‐being of families, FCR fosters scholarly discourse aimed at facilitating efficient resolutions of family disputes. In line with these values, the current study conducted an examination of articles published from 1998 to 2023 to understand how issues of diversity have been addressed. The analysis revealed an underrepresentation of quantitative empirical studies compared to other research types that were published in the journal. Furthermore, only a small minority of the empirical studies included important demographic data about the sample and an even smaller percentage of studies incorporated issues of diversity into the conclusions or implications for future directions. Notably, there was a trend showing an increasing number of articles that include and focus on individual differences over the past 10 years. Findings advocate for a greater emphasis on including publications with empirical data and disclosed demographics to bolster the robustness and applicability of research findings. By accentuating the diversity elements present in research samples and discussing their implications, FCR can deepen the understanding of the potentially disparate challenges and needs of individuals from various cultural backgrounds, who are involved in family law processes.