bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of simple models for total nitrogen removal from agricultural runoff in FWS wetlands
Authors: Canet-Martí Alba , Grüner Sabrina , Lavrnić Stevo , Toscano Attilio , Streck Thilo , Langergraber Guenter 
Published: June 2022

Abstract
Free water surface (FWS) wetlands can be used to treat agricultural runoff, thereby reducing diffuse pollution. However, as these are highly dynamic systems, their design is still challenging. Complex models tend to require detailed information for calibration, which can only be obtained when the wetland is constructed. Hence simplified models are widely used for FWS wetlands design. The limitations of these models in full-scale FWS wetlands is that these systems often cope with stochastic events with different input concentrations. In our study, we compared different simple transport and degradation models for total nitrogen under steady- and unsteady-state conditions using information collected from a tracer experiment and data from two precipitation events from a full-scale FWS wetland. The tanks-in-series model proved to be robust for simulating solute transport, and the first-order degradation model with non-zero background concentration performed best for total nitrogen concentrations. However, the optimal background concentration changed from event to event. Thus, to use the model as a design tool, it is advisable to include an upper and lower background concentration to determine a range of wetland performance under different events. Models under steady- and unsteady-state conditions with simulated data showed good performance, demonstrating their potential for wetland design.
Satisfaction with Social Roles and Physical Function in Immune-mediated
Inflammatory Diseases: A Cross-Sectional Study
Authors: Spagnuolo Rocco , Iaquinta Francesco Salvatore , Mauro Daniele , Pantano Ilenia , Dastoli Stefano , Naty Saverio , Cosco Cristina , Mancina Rosellina Margherita , Iacono Daniela , Gaggiano Emanuela , Ruggiero Annarita , Nisticò Steven Paul , Ciccia Francesco , Grembiale Rosa Daniela , Patrizia Doldo 
Published: June 2022

Background:
Although mood disorders have been well characterized by immune-mediated inflammatory diseases, physical function and satisfaction with social roles have not yet been defined as independent domains.

Objective:
The study aims to assess satisfaction with social roles and physical function alterations in a population with immune-mediated inflammatory diseases and identify associated characteris-tics.

Methods:
Physical function and social role satisfaction were evaluated through the Patient-reported Outcomes Measurement System. Besides comparison between groups, univariate and multivariable logistic regression analyses were performed to identify independent predictors.

Results:
Two hundred sixty-five patients with immune-mediated inflammatory diseases and 206 controls were recruited. Compared to controls, patients with inflammatory bowel diseases had impaired physical function (p<0.001), while patients with inflammatory arthritis reported impair-ment in both domains (p<0.001, each). In the univariate logistic regression, gender, high school educational level, physical activity, and occupation were positively associated with physical func-tion and social role satisfaction (p<0.001; p=0.001; p<0.001; p=0.001 and p<0.001; p=0.012; p=0.008; p=0.004, respectively). Active disease and steroids were inversely associated with phys-ical function and social roles satisfaction (p=0.033; p=0.022 and p=0.002; p=0.038, respectively). Further associations were found between age and physical function (p=0.002) and biological treatment and ESR with social roles satisfaction (p<0.001; p=0.043; respectively). In the multivar-iable regression, gender was found to be associated with physical function (p<0.001) and social roles satisfaction (p=0.003). Negatively associated factors were biological treatment for satisfac-tion with social roles (p<0.001) and steroids for physical function (p=0.021), and social roles sat-isfaction (p=0.018).

Conclusion:
Immune-mediated inflammatory diseases determine alterations in physical function and social life satisfaction. Gender and treatment are independently associated factors. Patient-reported outcomes should be considered in clinical management to define patients’ real needs.
Role of DPP4 and DPP4i in Glucose Homeostasis and Cardiorenal Syndrome
Authors: Panda Siva Prasad 
Published: June 2022

Abstract:
The objective of the review led to the pursuit of adopting dipeptidyl peptidase-4 inhibitors
(DPP4i) as a novel pharmacotherapy in diabetes mellitus (DM) and cardiorenal syndrome
(CRS). The CRS is defined as the co-existence of myocardial ischemia with renal failure. At present,
the commercially available drugs enhance insulin secretion or action. However, most of the
drugs are associated with adverse effects, such as weight gain or hypoglycemia. As a result, newer
therapies with better safety and efficacy profiles are being explored. The DPP4 protease enzyme
is involved in cardiovascular and renal diseases in association with over-expressed cytokines. The
novel characteristic of DPP4i is to control the elevated blood glucose levels in response to nutrient
ingestion without causing hypoglycemia. Also, DPP4i are indirectly involved in reducing myocardial
ischemia by promoting cardioprotective peptides. They protect the glucagon-like peptide 1
(GLP-1) from the deteriorating effect of the DPP4 enzyme. The GLP-1 receptors (GLP-1R) are
abundantly expressed in renal and cardiovascular tissue. The overexpression of GLP-1R will confer
protection of the heart and kidney during CRS. DPP4i were found to significantly clear plasma
glucose by the simultaneously activating natural thrombolytic system and increasing insulin levels.
They can be used in the early stages of the disease, including pre-diabetes or obesity combined
with impaired incretin response, while the combination of DPP4i with metformin or thiazolidinediones
as insulin sensitizers offers an additional improvement in the treatment of DM. With its positive
attributes in a host of associated parameters of interest, DPP4i are studied extensively in the
present review.
The Effect of Ramp Proximity, Weather, and Time-of-Day on Freeway Accident Frequency: A Case Study on I-75 and I-24 in Hamilton County, TN
Authors: Laflamme Eric M. , Way Peter , Roland Jeremiah , Sartipi Mina 
Published: June 2022

Background:
We present a case study to quantify the dangers of freeway ramps by comparing the observed accident counts from ramp locations to those from adjacent mainline locations. Few works make this direct comparison. Additionally, time-of-day and weather information is considered to collect a deeper understanding of the nature of freeway accidents near ramps. Real-world data collected from freeways in Hamilton County, TN, are considered as an application and give interesting results.

Methods:
First, we precisely define ramp influence areas or areas within close proximity to ramp locations where traffic is suspected to be affected by the ramp structure/geometry. Then, we introduce a theoretically justified Negative Binomial regression model to approximate the relationship between accident counts (response), presence of ramp influence areas, and additional weather and time-of-day designations. Our model also considers selected interaction terms, route designation, and multiple random components that are aimed at explaining unmeasured sources of variation.

Results:
Based on the interpretation of our fitted statistical model, we find that being in an influence/ramp area (compared to being in mainline traffic), on average, results in a 4-fold increase in accident frequency. Moreover, we find that during clear conditions, rush hour conditions increase the accident frequency substantially, while during rainy conditions, this increase is much less stark. During non-rush hour conditions, rain decreases the accident frequency substantially, and during rush hours, this decrease is intensified. Model diagnostics and a validation procedure further justify the assumed model form and lend credence to our results.

Conclusion:
While we do not make any claim of transferability of our results, they provide a proof-of-concept that accident frequency is attributable to multiple factors, among which is proximity to ramps. Furthermore, our procedure and statistical model allow us to directly quantify how these factors, most notably ramp traffic, effect accident frequency. These results illuminate potential safety risks. Subsequent work considering more diverse roadways could provide the evidence needed for policy changes and/or remedial measures.
Application of Plant Extracts for the Synthesis of Nanoparticles in Green
Chemistry: A Concise Update
Authors: Chakraborty Prithviraj , Khatiwara Bunu , Singh Simran , Sarangi Samarpan , Das Arnab , Dhakal Jigyasha 
Published: June 2022

Abstract:
Green synthesis of nanoparticles is an emerging topic with many significant applications in environmental and biomedical fields. The main aim of green synthesis is the development of eco-friendly nanoparticles using biological materials like plants and microbes and thus, reducing the practice of utilizing toxic substances. Different plant-derived materials are regularly utilized to synthesise sustainable nanoparticles with almost comparable properties yet utilize less hazardous manufacturing processes. This review aims to update these green synthetic processes for developing nanoparticles.
Management of Strategic Competitiveness of Industrial Enterprises: Assessment, Implementation of Technological and Managerial Innovations
Authors: Kalynychenko M. P. 
Published: June 2022

The relevance. In the modern VUCA-world, instability, uncertainty, complexity and ambiguity in the external environment of industrial enterprises are growing rapidly. Top management is required to produce and implement innovations, including managerial and technological ones, formed on the basis of a sustainable development model.The purpose of the article is to develop scientific and methodological approaches to managing the competitiveness of an industrial enterprise.Objectives: to develop a methodological approach to assessing the competitiveness of an industrial enterprise, taking into account the nature of economic relations between an industrial enterprise and its stakeholders; substantiate the feasibility of using technological and managerial innovations as factors in increasing the competitiveness of an industrial enterprise.The research methodology includes a combination of systemic, logical, empirical and comparative methods of analysis; of static and dynamic approaches, which made it possible to comprehensively consider the processes of forming the competitiveness of industrial enterprises. Also, the article used general scientific methods of analysis and synthesis, ascent from the abstract to the concrete and from the general to the particular, as well as the methods of statistical and economic analysis.Results. An approach to understanding the competitiveness of enterprise through the prism of the «stakeholders ‒ industrial enterprise ‒ stakeholders» system is proposed. It is substantiated that the subject of management is subject to the need to establish and maintain compliance, the relationship between the set of parameters (indicators) of the competitiveness of an industrial enterprise and their respective interests with the parameters and interests of stakeholders. A scientific and methodological approach to the integral assessment of the competitiveness of an enterprise has been developed, and the priorities for managing the CP as an innovative process have been justified.Conclusion. Testing the proposed approach to the integrated assessment of the competitiveness of Mining Equipment LLC showed that the value of this assessment is directly dependent on the consistency of joint interests.
Association of HLA Mismatches and Histology Suggestive of Antibody-Mediated Injury in the Absence of Donor-Specific Anti-HLA Antibodies
Authors: Senev Aleksandar , Lerut Evelyne , Coemans Maarten , Callemeyn Jasper , Copley Hannah Charlotte , Claas Frans , Koshy Priyanka , Kosmoliaptsis Vasilis , Kuypers Dirk , Sprangers Ben , Van Craenenbroeck Amaryllis , Van Loon Elisabet , Van Sandt Vicky , Emonds Marie-Paule , Naesens Maarten 
Published: June 2022

Background and objectives
The histology of antibody-mediated rejection after kidney transplantation is observed frequently in the absence of detectable donor-specific anti-HLA antibodies. Although there is an active interest in the role of non-HLA antibodies in this phenotype, it remains unknown whether HLA mismatches play an antibody-independent role in this phenotype of microcirculation inflammation.

Design, setting, participants, & measurements
To study this, we used the tools HLAMatchmaker, three-dimensional electrostatic mismatch score, HLA solvent accessible amino acid mismatches, and mismatched donor HLA–derived T cell epitope targets to determine the degree of HLA molecular mismatches in 893 kidney transplant recipients with available biopsy follow-up. Multivariable Cox proportional hazards models were applied to quantify the cause-specific hazard ratios of the different types of HLA mismatch scores for developing antibody-mediated rejection or histology of antibody-mediated rejection in the absence of donor-specific anti-HLA antibodies. In all survival analyses, the patients were censored at the time of the last biopsy.

Results
In total, 121 (14%) patients developed histology of antibody-mediated rejection in the absence of donor-specific anti-HLA antibodies, of which 44 (36%) patients had concomitant T cell–mediated rejection. In multivariable Cox analysis, all different calculations of the degree of HLA mismatch associated with developing histology of antibody-mediated rejection in the absence of donor-specific anti-HLA antibodies. This association was dependent neither on the presence of missing self (potentially related to natural killer cell activation) nor on the formation of de novo HLA antibodies. Also, glomerulitis and complement C4d deposition in peritubular capillaries associated with the degree of HLA mismatch in the absence of anti-HLA antibodies.

Conclusions
The histology of antibody-mediated rejection and its defining lesions are also observed in patients without circulating anti-HLA antibodies and relate to the degree of HLA mismatch.
Developing analytical skills through optimizing the learning process by science teachers in Nganjuk Regency
Authors: Yakub Pramita , Puspitawati Rinie Pratiwi , Bashri Ahmad 
Published: June 2022

Based on the results of the interviews, it was found that science teachers in Nganjuk Regency did not understand and master the skills of analyzing, especially with Biology material so that there was a need for training to practice analytical skills through optimizing learning. This training activity aimed to develop analytical skills through optimizing the learning process. This training activity involved 10 junior high school teachers who are members of the Science Subject Teacher Association (Musyawarah Guru Mata Pelajaran/MGMP) of Nganjuk Regency. The method used was observation and data were analyzed in descriptive qualitative. The implementation of the activities were divided into three stages, namely the preparation, implementation, and evaluation stages and feedback, as well as participant responses. The results of the responses based on the questionnaire were positive with a score of 3.82, very good training material at 3.82, and very good training conditions with a score of 3.84. There was an increase in the learning analysis skills of MGMP participants with a percentage of 82.40%.
Mark-to-Market, Loan Retention, and Loan Origination
Authors: Bleck Alexander , Gao Pingyang 
Published: June 2022

ABSTRACT
We study the effects of mark-to-market accounting (MTM) for banks following the originate-to-distribute lending model. Banks have expertise in originating loans, but it is costly for them to retain the loans on their books. We study how the accounting measurement of the retained loans affects the banks’ origination and retention decisions. We show that, relative to historic cost accounting (HC), MTM has three consequences. First, it improves the accuracy of loan measurement ex post. Second, it forces banks to retain more risk exposure on their own books. Finally, it can reduce ex ante origination efforts and lower the average quality of loans in the economy.
JEL Classifications: G01; G21; G30; M41.
Analisis Ungkapan Tradisional Melayu Jambi: Kajian Hermeneutik
Authors: Warni Warni , Afria Rengki 
Published: June 2022

AbstrakSebagai bagian dari kebudayaan, ungkapan tradisional menarik untuk dikaji. Ungkapan tradisional sebagai khazanah tak benda mengandung nilai, makna, dan seni berbahasa masyarakat melayu Jambi. Penelitian ini bertujuan untuk menginventarisasi, mendokumentasi, mendeskripsi, dan menganalisis bentuk, jenis-jenis, fungsi, dan makna Ungkapan Tradisional Melayu Jambi: Kajian Hermeneutik. Metode yang digunakan adalah metode deskriptif kualitatif. Sumber data berupa ungkapan tradisional melayu Jambi . Data penelitian ini adalah pepatah, petitih, kias, peribahasa dalam bahasa Melayu Jambi. Hasil penelitian disimpulkan bahwa beberapa data ungkapan tradisional melayu Jambi, baik berupa peribahasa, pepatah, maupun perumpamaan. Masyarakat Melayu Jambi pada umumnya dalam bertutur bersifat tidak terbuka, sehingga mereka menggunakan kiasan-kiasan untuk menyampaikan pesan dalam tuturan tersebut. Ungkapan tradisional Melayu Jambi mempunyai fungsi dalam kehidupan bersosial dimasyarakat. Fungsi tersebut adalah: Sebagai sarana edukasi masyarakat, Sebagai nasehat, dan Sebagai khazanah budaya tradisi lisan. Implikasi teoritis dalam penggunaan metode yang tepat dapat menghasilkan analisis data yang akurat. Secara praktis hasil kajian ini dapat diimplikasikan sebagai rujukan, dan pembanding dari penelitian-penelitian selanjutnya yang mendalami kajian hermeneutik.Kata Kunci: ungkapan, tradisional, melayu jambi, hermeneuticAbstractAs part of culture, traditional expressions are interesting to study. Traditional expression as a treasure not object contains the value, meaning, and language arts Jambi Malay community. This research aims to inventory, document, describe, and analyze the shape, type, function and meaning of expressions Traditional Malay Jambi: Study hermeneutic. The method used is a qualitative descriptive method. Data source Jambi Malay traditional form of expression. This research data is the maxim, proverb, analogy, saying in Malay Jambi. The results conclude that the number of traditional Malay Jambi expression data, in the form of proverbs, sayings, or parables. Jambi Malay community in general in the converse is not open, so they use metaphors to convey the message in speeches. Jambi Malay traditional expression has a function in the life of the community socialization. These functions are: As a means of public education, As advice, and As a cultural treasure of oral tradition. Theoretical implications in the use of appropriate methods can result in accurate data analysis. In practice, the results of this study can be implied as a reference, and a comparison of further studies that delve into hermeneutic studies.Keywords: expressions, traditional, Jambi Malay, hermeneutic
Tradisi “Mbeleh Wedhus Kendhit” Sebagai Sarana Tolak Balak di Masa Pandemi Covid-19
Authors: Yusuf M. , Basyid Abd. 
Published: June 2022

Penelitian ini bertujuan untuk mendeskripsikan tradisi mbeleh wedhus kendhit sebagai sarana tolak bala di masa pandemi covid-19, juga untuk mengetahui bagaimana konstruksi pemahaman masyarakat mengenai tradisi mbeleh wedhus kendhit sebagai sarana tolak bala di masa pandemi covid-19, dan terakhir, untuk mengetahui nilai yang terkandung dalam tradisi mbeleh wedhus kendhit sebagai sarana tolak bala di masa pandemi covid-19. Untuk menjawab tujuan penelitian tersebut, penulis menggunakan pendekatan kualititatif dengan jenis fenomenologis. Setelah data terkumpul, untuk mencari konstruksi pemahaman, dianalisis dengan menggunakan teori konstriuksi sosial Berger dan Luckman tentang subjective reality, symbolic reality, dan objective reality, juga tentang eksteralisasi, objektifikasi, dan iternalisasi. Sedangkan untuk mencari nilai yang terkandung dalam tradisi, menggunakan analisis descriptive-eksplorative. Dari hasil penelitian tersebut diketahui bahwa, tradisi ini merupakan rangkaian acara yang dimulai dari penyembelihan wedhus kendhit hingga doa bersama di lapangan dusun, dilaksanakan secara tentatif ketika terjadi pagebluk, seperti pagebluk covid-19. Masyarakat memahami bahwa tradisi mbeleh wedhus kendhit adalah sumber segala nilai, lanjut melaksanakan, kemudian mereka mendapatkan suatu kebenaran kolektif tentang adanya khasiat sebagai sarana tolak bala. Nilai yang terkandung dalam tradisi “mbeleh wedhus kendhit” ada dua, yakni nilai ilahiyah dan nilai insaniyah.
Cadar dan Jilbab menurut Dogma Agama dan Budaya Masyarakat (Studi Living Qur’an Surat Al-Ahzab ayat 59 pada Masyarakat Sumatera Barat)
Authors: Nasrulloh Nasrulloh , Mela Desriliwa Ade 
Published: June 2022

Penelitian ini didasari adanya tiga aliran besar mengenai cadar, yaitu aliran yang mengatakan wajib, sunnah dan mubah. Sebagian masyarakat ada yang menganggap sebagai teroris dan ada juga masyarakat lain yang menganggap cadar sebagai tren saja. Al-Qur’an memerintahkan para muslimah agar berhijab dengan mengenakan kerudung yang dapat menutupi kepala dan dada mereka, namun ada yang berbeda pendapat mengenai ayat tersebut. Lubuk Lintah adalah daerah yang berada di kecamatan Kuranji di Sumatera Barat, Padang. Tujuan penelitian ini untuk menganalisis pendapat para ulama klasik-kontemporer mengenai surat al-ahzab ayat 59 dan menganalisis pandangan masyarakat mengenai cadar dan jilbab di Lubuk Lintah Sumatera Barat. Metode yang digunakan adalah deskriptif kualitatif dengan pendekatan tafsir-etnografi. Hasil penelitian ini menunjukkan adanya perbedaan penafsiran ulama klasik dan kontemporer mengenai makna surah al-ahzab ayat 59, ada yang berpendapat bahwa ayat tersebut mengenai perintah cadar, dan ada yang berpendapat bahwa ayat tersebut mengenai perintah menutup aurat yakni tentang hijab. Adapun pandangan masyarakat Sumatera Barat mengenai cadar dan jilbab, sebagian dari mereka bisa menerima eksistensi wanita bercadar, dan ada beberapa kelompok masyarakat yang belum bisa menerima perempuan yang memakai cadar, dikarenakan mereka yang bercadar menutup diri mereka dari masyarakat dan enggan bertegur sapa dengan lingkungan sosial.
Education in the Sultanate of Siak: The Study of Manuscripts and Archives of Siak Sri Indra Pura, Riau
Authors: Abduh Arrafie , Roza Ellya , Erni Sukma 
Published: June 2022

This study discusses education in the Sultanate of Siak by studying manuscripts and archives. Manuscripts and archives are the main basis of the information requested about the education needed. The method used is philological and historical research so that the results obtained can be thought of as real education in the imperial era. Research findings on education that get full attention from sulthan are religiously based education. Education is accessed in 3 places ; mosque (surau) domains, schools and ma'had. Education that is carried out in the mosque (surau) about the education of the wider community which includes not only quran learning (reciting), but also usul ul fiqh, tariqat and qasidah (sound art). Education carried out in schools (madrasas) and ma'had also includes learning Qur`an, Islamic law, gramatical, etc. All teachers involved in education must go through the legalization of sultan even though they only teach the Koran (Qur`an). Legalization of becoming a teacher through several processes involving the data collection, qadi to accept eligibility and sultan licensor