bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cuando las armas son las letras: Sobre la compleja gestación de la Platica manual de artilleria de Luis Collado
Authors: De la Fuente de Pablo Pablo 
Published: November 2022

Este artículo pretende centrarse en el estudio de dos factores nada conocidos y, además, esenciales para la comprensión de la Platica manval de Luis Collado, el más importante tratado de artillería del siglo XVI. El primero de ellos es explicar las razones que llevaron a las importantísimas diferencias cuantitativas y cualitativas entre la versión italiana de 1586 y la española de 1592. El segundo se propone explicar qué consecuencias profesionales tuvo para Collado el publicar su obra. A partir, principalmente, del análisis bibliológico y de fuentes de archivo inéditas convenientemente contextualizadas, en este trabajo se detallan las ambiciones profesionales que Collado pretendía colmar convirtiéndose en tratadista y aquellas que se cumplieron. También explica la diferencia entre las dos citadas ediciones como una respuesta a la aparición del tratado de Diego de Álava y Viamont en 1590.
Koncerty charytatywne w Lublinie w świetle relacji prasowych (1900-1914)
Authors: Kubas Anna 
Published: November 2022

W wyniku kwerendy wybranych czasopism lubelskich z lat 1900-1914 autorka odnalazła informacje na temat koncertów charytatywnych organizowanych we wspomnianym okresie w Lublinie.
Klęski kolejnych powstań narodowo-wyzwoleńczych spowodowały, że ludność polska porzuciła myśl o zbrojnym odzyskaniu niepodległości. Wpisując się w pozytywistyczny nurt pracy u podstaw, postanowiono skupić uwagę na edukacji młodzieży, która miała zachować w swoich sercach polskość, a w przyszłości być gotowa stanąć do walki o wolność. W tym właśnie duchu osoby prywatne, ale znacznie częściej towarzystwa i organizacje społeczne podejmowały się organizowania koncertów charytatywnych, z których dochód w zdecydowanej większości był przeznaczony na rzecz niezamożnych uczniów. Działalność tę poniekąd ułatwiła rewolucja w zaborze rosyjskim w latach 1905-1907.
Wielu artystów, zarówno miejscowych, jak i przyjezdnych, chętnie angażowało się w te wydarzenia, których repertuar, zaprezentowany w poniższym artykule, był bardzo bogaty i często zaskakujący.
A CULTURA DO BRINCAR E O TEA
Authors: Sousa Neide Maria Fernandes R. de , Corrêa Jéssica Do Socorro Leite , Saraiva Luis Junior Costa 
Published: November 2022

O presente vídeo etnográfico tem como propósito apresentar características sobre o brincar de crianças com TEA (Transtorno do Espectro Autista). Ele é resultado das vivências de pais e mães de crianças autista em diálogo com o espaço de pesquisa Laboratório de Inclusão (UFPA/campus Bragança). Apresentar a ludicidade de crianças que estão no espectro autista representa uma dimensão de discussão sobre a temática TEA. O brincar faz parte da subjetividade infantil, e é utilizado como principal ferramenta de desenvolvimento e aprendizagem da criança nos espaços educacionais, terapêuticos e familiares. O filme trás características sobre o brincar de crianças autista e sua importância para a infância, com relatos de pais e professora que vivenciam essas experiências. Assista aqui.
Pengembangan Bahan Ajar Matematika Bidang Kajian Bilangan Berbasis Computer Science Unplugged (CSU) untuk Siswa Sekolah Dasar
Authors: Mufliva Rosiana , Iriawan Sandi Budi 
Published: November 2022

Penelitian ini bertujuan untuk mengembangkan bahan ajar sebagai upaya meningkatkan kompetensi siswa khususnya pada bidang kajian bilangan dalam rangka mendukung tercapainya indikator hasil belajar siswa serta untuk memperoleh gambaran mengenai kelayakan dan respon siswa terhadap penggunaan bahan ajar matematika berbasis <em>Computer Science unplugged</em> (CSU) pada bidang kajian bilangan. Penelitian ini dilaksanakan dengan menerapkan metode <em>Research and Development</em> (R&amp;D) dengan model pengembangan ADDIE. Model ini terdiri dari lima langkah, yaitu: 1) analisis, 2) perancangan, 3) pengembangan, 4) penerapan dan 5) evaluasi. Hasil penelitian ini menunjukkan bahwa bahan ajar matematika bidang kajian bilangan berbasis CSU layak untuk digunakan dengan persentase sebesar 91 % dengan kategori sangat layak menurut ahli materi dan ahli desain bahan ajar. Sedangkan hasil uji coba terhadap peserta didik menunjukkan bahwa bahan ajar matematika bidang kajian bilangan berbasis CSU ini menunjukkan persentase sebesar 90% dengan kategori sangat layak. Simpulan dari penelitian ini adalah bahwa bahan ajar matematika bidang kajian bilangan berbasis CSU ini dapat digunakan untuk membantu siswa dalam memahami materi bilangan siswa kelas 1 SD.
Barreiras de Acessibilidade para Pessoas com Deficiência no Ensino Superior
Authors: De Santana Porte Marcelo , Damião Trindade Rocha José , Augusto Pereira Cleber 
Published: November 2022

Objetivo da pesquisa: O objetivo do estudo foi realizar uma revisão de literatura sobre as barreiras de acessibilidade sofridas pelas Pessoas com Deficiência (PcD) no ensino superior.
Enquadramento teórico: Os artigos foram analisados à luz da Lei Brasileira de Inclusão n. 13.146/2015 para categorizar as suas barreiras de acessibilidade (Urbanísticas; Arquitetônicas; nos Transportes; nas Comunicações e na Informação; Atitudinais; e Tecnológicas).
Metodologia: Para a metodologia, utilizou-se a análise léxica aplicada à Classificação Hierárquica Descendente, associada a Análise de Similitude e Nuvem de Palavras das publicações da SciELO Citation Index, coleção SciELO Brasil, indexadas na base de dados da Web of Science de 2002 a 2019, sendo analisados 45 estudos científicos.
Resultados: Os resultados demonstram a existência de duas classes como tendência para as publicações na área, sendo a primeira voltada para o ensino superior público e privado; e a outra, para Institutos e Universidades Federais. Além disso, há um direcionamento para realização de estudos para PcD visual e auditiva, e a principal limitação evidenciada na literatura é a Barreira nas Comunicações e na Informação.
Originalidade: O presente estudo se torna original por não ter sido encontrado nenhum outro trabalho científico que realizasse uma Meta-Revisão Sistemática de Literatura das publicações em periódicos no Brasil, com o uso de análise de classes realizadas por um sistema de análise qualitativa para o presente tema.
Contribuições teóricas e práticas: Ressalta-se que, normalmente, os trabalhos que utilizam as Barreiras nas Comunicações e na Informação como uma das variáveis em seus estudos, possuem também como variável indicadores de Barreiras Tecnológicas. A principal política pública evidenciada para o ensino superior no país é o Programa Incluir, do Governo Federal.
Predictors of Severe COVID-19 among Healthcare Workers in Sabah, Malaysia
Authors: Joo Lim Kai , Sazali Mohd Fazeli , Goroh Michelle , Zefong Abraham Chin , Maluda Marilyn Charlene Montini , Avoi Richard , Gantul Valentine Japulee 
Published: November 2022

Abstract
Background: Healthcare workers ((HCWs) is the high-risk group for COVID-19 infection due to increased workplace exposure. However, evidence of the disease burden and factors associated with the severe COVID-19 infection among HCW is limited. Therefore, this article aims to describe the prevalence of severe COVID-19 disease among healthcare workers in Sabah, Malaysia, and to determine the factors associated with severe COVID-19 infection.
Method: A retrospective cross-sectional study was carried out by assessing the data of COVID-19 infected HCWs in Sabah, Malaysia, from 1st March 2021 until 30th September 2021. Logistic regression analysis was used in this study.
Results: 3040 healthcare workers were diagnosed with COVID-19 from 1st March 2021 until 30th September 2021. Of the 3040 HCWs, 2948 (97.0%) HCWs were mild, whereas 92 (3.0%) were severe. The multivariate logistic regression model showed that severe COVID-19 among HCWs in Sabah was associated with those do not receive any COVID-19 vaccination (aOR 6.061, 95% CI 3.408 – 10.780), underlying co-morbidity (aOR 3.335, 95% CI 2.183 – 5.096), and female (aOR 1.833, 95% CI 1.090 – 3.081).
Conclusion: HCWs should strictly adhere to preventive measures, including vaccination, personal protective equipment, and early referral to a physician upon identifying severe COVID-19 infection. Early screening and aggressive co-morbidity treatment among healthcare workers are essential for public health practitioners to prevent severe COVID-19 disease. Healthcare workers with uncontrolled co-morbidities are the group to be prioritised to get the vaccination.
Ancestral social environments plus nonlinear benefits can explain cooperation in human societies
Authors: Kristensen Nadiah Pardede , Ohtsuki Hisashi , Chisholm Ryan Alistair 
Published: November 2022

Abstract
Human cooperation (paying a cost to benefit others) is puzzling from a Darwinian perspective, particularly in groups with strangers who cannot repay nor are family members. The beneficial effects of cooperation typically increase nonlinearly with the number of cooperators, e.g., increasing returns when cooperation is low and diminishing returns when cooperation is high. Such nonlinearity can allow cooperation between strangers to persist evolutionarily if a large enough proportion of the population are already cooperators. However, if a lone cooperator faces a conflict between the group's and its own interests (a social dilemma), that raises the question of how cooperation arose in the first place. We use a mathematically tractable evolutionary model to formalise a chronological narrative that has previously only been investigated verbally: given that ancient humans interacted mostly with family members (genetic homophily), cooperation evolved first by kin selection, and then persisted in situations with nonlinear benefits as homophily declined or even if interactions with strangers became the norm. The model also predicts the coexistence of cooperators and defectors observed in the human population (polymorphism), and may explain why cooperators in behavioural experiments prefer to condition their contribution on the contributions of others (conditional cooperation in public goods games).
Geological perspectives of future equatorial sea level from the Sunda Shelf and Singapore
Authors: Shaw Timothy , Li Tanghua , Ng Trina , Cahill Niamh , Chua Stephen , Majewski Jedrzej , Nathan Yudhish , Garner Greg , Kopp Robert , Hanebuth Till , Switzer Adam , Horton Benjamin 
Published: November 2022

Abstract
Low-lying equatorial islands are susceptible to relative sea level (RSL) rise. Here, we quantify magnitudes and rates of RSL change since the last glacial maximum (LGM) to provide probability perspectives of future sea level. Geological reconstructions and instrumental records from the Sunda Shelf and Singapore show RSL rose ~ 121 m at rates up to ~ 15 mm/yr since the LGM, which reduced the paleogeographic landscape by ~ 2.3 million km2. In the 20th century, RSL began to rise, increasing at a rate of ~ 1.7 mm/yr to ~ 2.2 mm/yr between 1915 and 2020 CE. Future projections under a moderate emissions scenario show RSL rising 0.95 m at a rate of 7.3 mm/yr by 2150 which has only been exceeded (at least 99% probability) during rapid ice melting events ~ 14.5 and ~ 9 thousand years ago. Future projections under a high emissions scenario incorporating low confidence ice-sheet processes, however, have no precedent since the LGM.
Sleep disturbances and retardation in the prediction of cognitive impairments in patients with major depressive disorder
Authors: Wang Mi , Chen Wentao , Liu Bangshan , Ju Yumeng , Dong Qiangli , Lu Xiaowen , Sun Jinrong , Zhang Liang , Guo Hua , Zhao Futao , Li Weihui , Zhang Li , Li Zexuan , Liao Mei , Zhang Yan , Liu Jin , Li Lingjiang 
Published: November 2022

Abstract
Background: Symptoms of depression and comorbid anxiety have been regarded as risk factors responsible for cognitive impairment in major depressive disorder (MDD). However, it remains unclear which dimension of the depressive and anxiety symptoms predicts cognitive impairment during a depressive episode.
Methods: A comprehensive neurocognitive test battery was used to assess executive function, attention, processing speed, and memory in 162 medication-free patients with MDD and 142 matched healthy controls (HCs). The 24-item Hamilton Depression Rating Scale (HAM-D) was used to assess depressive symptoms (including 7 dimensions: retardation, cognitive disturbances, sleep disturbances, anxiety/somatization, weight loss, diurnal variation and hopelessness), and the 14-item Hamilton Anxiety Scale (HAM-A) was used to assess anxiety symptoms. Linear regression analyses and mediation analyses were conducted to evaluate the impact of depressive and anxiety symptoms, as well as their interactions, on cognitive impairments.
Results: Among the depressive symptoms, sleep disturbances were associated with poorer executive function, lower processing speed, and memory impairments, and retardation was associated with lower processing speed in patients with MDD. Notably, retardation was found to mediate the impact of sleep disturbances on the processing speed. With regard to anxiety symptoms, psychic anxiety, rather than somatic anxiety, was associated with cognitive impairments of all the four aspects. Furthermore, sleep disturbances were found to mediate the impact of psychic anxiety on executive function and memory, while retardation was found to mediate the impact of psychic anxiety on processing speed.
Conclusions: The present study provided preliminary evidence that sleep disturbances might be a significant predictor for poorer executive function, lower processing speed, and memory loss, while retardation might be a major factor for lower processing speed during a depressive episode.
Environmental predictors of SARS-CoV-2 infection incidence in Catalonia (northwestern Mediterranean)
Authors: Morató Jesús Planella , Pelegrí Josep Lluís , Rey Marta Martín , Abelló Anna Olivé , Vallès Xavier , Roca Josep , de Liria Carlos Rodrigo Gonzalo , Estrada Oriol , Casanova Ignasi Vallès 
Published: November 2022

Abstract
Numerous studies have explored whether and how the spread of the coronavirus disease 2019 (COVID-19) responds to environmental conditions without reaching unique or consistent answers. Sociodemographic factors such as variable population density or mobility as well as the lack of effective epidemiological monitoring difficult establishing robust correlations. Here we carry out a regional cross-correlation study between nine atmospheric variables and an infection index (Ic) estimated from standardized positive polymerase chain reaction (PCR) test cases. The correlations and associated time-lags are used to build a linear multiple-regression model between weather conditions and the Ic index. Our results show that surface pressure and relative humidity can predict COVID-19 outbreaks during periods of relatively minor mobility and meeting restrictions. The occurrence of low-pressure systems, associated with the autumn onset, leads to weather and behavioral changes that intensify the virus transmission. These findings suggest that surface pressure and relative humidity are key environmental factors in the seasonal dynamics of the COVID-19 spread, which may be used to improve COVID-19 forecast models.
Efficacy and tolerability of SEDIFLÙ® in treating dry or productive cough in the paediatric population (SEPEDIA). A pilot, randomized, double blind, placebo-controlled, multicentre clinical trial.
Authors: Nuñez Carlos , Chiatti María Cristina , Tansella Francesco , Coronel Cristóbal , Risco Ester 
Published: November 2022

Abstract
Background: Nonpharmacological interventions, such as throat and pharynx demulcents and emollients, are an alternative for cough management and mucosa protection, especially in children, who experience upper respiratory infection-associated acute cough almost four times more than adults. The aim of this trial was to assess the effectiveness of Sediflù®, a medical device containing active herbal ingredients, on nocturnal and diurnal persistent coughs in children, with a duration of 3 to 7 days.
Methods: Children with a dry and/or productive cough were enrolled in this prospective, interventional, multicentre, placebo-controlled, double-blind, randomized clinical study. Clinical efficacy was assessed through the evaluation of the soothing action of Sediflù® against dry and/or productive coughing, both at night and during the day and other effects of coughing associated with quality of sleep: frequency, child’s quality of sleep, parental quality of sleep, severity and bothersomeness.
Results: Treatment with Sediflù® improved both night- and day-time cough scores from D2. The improvement of the night-time cough score is statistically significantly higher in the Sediflù® group (28% and 71% lower) at D4 and D7, respectively, in comparison to the placebo group (p<0.05). The diurnal score improved significantly in the Sediflù® group (22% and 71% lower) at D3 and D7, respectively, in comparison to the placebo group (p<0.05 and p<0.01, respectively).
There was also a significant decrease in the scores of five nocturnal variables associated with sleep quality (frequency, severity, bothersomeness, child’s and parental quality of sleep) from D2, and it was maintained throughout the rest of the days (D3-D7). Considering the inter-group analysis, Sediflù® showed a more significant improvement for frequency, severity, bothersomeness, child’s and parental quality of sleep (70%, 51%, 52%, 58% and 66% lower, respectively) at D7, in comparison to the placebo group (p<0.01).
The analysis of a subgroup of children, with cough scores ≥ 3, showed a significant reduction of both frequency and severity scores from the first day of treatment with Sediflù® (p<0.05).
Conclusions: Sediflù® syrup can be considered a valid treatment for cough management, especially in younger children with upper respiratory tract infections, shortening the cough duration in children, with a very good safety profile.
Trial registration: NEOPS-AEMPS, NEOPS Num 20-0040, Registered 22 December 2020, https://neops.aemps.es/
A randomized controlled trial of adjuvant inhalable sodium bicarbonate role in treatment of COVID-19
Authors: El-Badrawy Mohammad , Elmorsey Rehab , shehta Mohammed , El-Hadidy Tamer , abdelwahab ibrahim , El-Badrawy Adel , Shokeir Ahmed 
Published: November 2022

Abstract
Entry of coronavirus (SARS-CoV-2) into a host cell is pH dependent. Intracellular alkalinization by sodium bicarbonate (SB) could elevate endosomal pH and block viral entry into the host cells. So, we assessed the role of inhalable SB as an adjuvant treatment for COVID-19 in the study groups of this randomized, controlled trial. Here we show a significantly shorter duration to clinical improvement and hospital stay in the study group, while the number of deaths is significantly less only in severe grade of the study group. But the time to death is not significantly different in both groups. CRP and d-dimer levels are significantly lower in the severe cases of the study group. The overall median CT score is significantly better in the study group at one & 2 months. Our data thus suggest that inhaled SB (8.4%) could be a possible adjuvant therapy for patients with moderate and severe COVID‑19 pneumonia.
Ultrasonic Measurement of the Narrowest Transverse Diameter of Subglottic Airway in Children Undergoing Elective Tracheal Intubation under General Anesthesia
Authors: Zheng Fang , Dou Zhilan , Lin Yawen , Ding Leiming , Zhu Kailai , Cheng Hao 
Published: November 2022

Abstract
Backgroud: it was to study the application effect of ultrasonic measurement of the narrowest airway transverse diameter (TD) at the horizontal position of subglottic cricoid cartilage in the selection of endotracheal tube (ETT) in children with elective tracheal intubation (TI) under general anesthesia (GA).
Methods: 65 children undergoing elective TI under GA were enrolled as research objects, including 29 males and 21 females. There were 35 cases received uncuffed ETT while 30 cases adopted cuffed one. The type of ETTs was selected by ultrasonic measurement of TD of the subglottic airway and the age equation. The correlation between age, height, weight, subglottic airway TD and clinical optimal inner diameter (ID) of ETT was analyzed statistically. Results: The accuracy of ultrasonic measurement method and age equation method with uncuffed ETT were 91.42% and 54.28%, respectively (P<0.05). The accuracy with cuffed ETT turned out to be 86.66% and 36.66%, respectively (P<0.05). There were correlations of age, height, weight, and subglottic airway TD with ID of the uncuffed or cuffed ETTs. The higher correlation was shown between subglottic airway TD and ID of ETT. Conclusion: The narrowest airway measurement by ultrasonography at the horizontal position of subglottic cricoid cartilage could be applied to evaluate the selection of uncuffed or cuffed ETT during TI under GA in children. This method was simple to operate, accurate, and worthy of clinical application significance.
Betaine suppresses hepatic steatosis: Inhibition of FoxO6 and PPARγ interaction
Authors: Kim Mi Eun , Park Min Hi , Lee Jun Sik , Kim Dae Hyun 
Published: November 2022

Abstract
Betaine is the major water-soluble component of Lycium chinensis. Although there are reports of a protective effect of betaine on fatty liver disease, the underlying mechanisms are unclear. We investigated the effects of betaine on forkhead box O6 (FoxO6) and peroxisome proliferator-activated receptor gamma (PPARγ) expression, which are associated with hepatic lipid accumulation. In this study, we attempted to elucidate the molecular regulation of betaine on hyperglycemia-induced lipid accumulation via FoxO6 activation. HepG2 cells and liver tissue isolated from db/db mice treated with betaine at a dose of 50 mg/kg/day for 3 weeks were used. In the present study, we investigated whether betaine ameliorates hepatic steatosis by inhibiting FoxO6/PPARγ signaling in liver cells. Interestingly, betaine notably decreased lipid accumulation in FoxO6-induced mRNA expression of lipogenesis-related genes. In addition, hepatic insulin signaling was decreased; and activation of FoxO6, which is negatively regulated by Akt, was reduced by betaine treatment. Furthermore, betaine inhibited the FoxO6 interaction with PPARγ and cellular triglycerides in high-glucose- or FoxO6-overexpression-treated liver cells. In addition, we confirmed that betaine administration via oral gavage significantly ameliorated hepatic steatosis in db/db mice. The protein level of PPARγ, a lipogenic transcription factor, was decreased in the livers of db/db mice. Therefore, it has previously been shown to induce hepatic steatosis. We conclude that betaine ameliorates hepatic steatosis, at least in part, by inhibiting the interaction between FoxO6 and PPARγ, thereby suppressing lipogenic gene transcription.
Global health open-source goggles for fluorescence-guided surgery
Authors: Shmuylovich Leonid , O'Brien Christine , Nwosu Karen , Achilefu Samuel 
Published: November 2022

Abstract
Fluorescence-guided surgery (FGS), coupled with novel near infrared (NIR) fluorescent contrast agents, has significant potential to improve health but in current practice is less suitable for low resource settings. Although there are efforts to simplify FGS systems, technical, economic, and logistic challenges have hampered its global adoption. To overcome these impediments, we developed a low-cost, open-source, battery-powered and fully wearable FGS system called the fluorescence imaging augmented reality Raspberry Pi-based goggle system (FAR-Pi). Compared to current technologies that are expensive, bulky, and wall-powered, FAR-Pi has higher spatial resolution, depth of focus and fluorescence sensitivity. The FAR-Pi system has broad appeal by detecting the diverse fluorescence of NIR contrast agents undergoing clinical trials, as demonstrated by the successful identification of tumors in vivo with LS301, a tumor-targeting NIR contrast agent. As an open-source, inexpensive, and modifiable system, FAR-Pi promises to broaden access to FGS, thereby improving health worldwide.