bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thiomethylphenyl Benzenesulfonamides as Potential Cholesteryl Ester Transfer Protein
Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation
Authors: Khalaf Reema Abu , Asa'ad Manal , Habash Maha 
Published: June 2022

Background:
The number of lipid disorders cases has risen dramatically around the
world as a result of poor dietary habits, hereditary risk factors, or other diseases or medicines.
Cholesteryl ester transfer protein (CETP) is a 476 amino acid lipophilic glycoprotein that
helps transport cholesteryl esters and phospholipids from proatherogenic LDL and VLDL to
atheroprotective HDL. CETP inhibition increases HDL cholesterol, lowers LDL cholesterol
and triglycerides, rendering it a promising therapy option for hyperlipidemia and its comorbidities.

Methods:
In this research, fourteen benzenesulfonamides 7a-7g and 8a-8g were synthesized
and identified using 1H-NMR, 13C-NMR, IR and MS. The in vitro biological evaluation of 7a-
7g and 8a-8g revealed CETP inhibitory activities ranging from 15.6 to 100% at 10 μM concentration.

Results:
Four aromatic rings compounds bearing either m-CH3 (8c) or p-Cl (8g) were the most potent compounds
with 100% CETP inhibition, while the most active compound was 7c bearing three aromatic rings and m-CH3 with
an IC50 of 0.12 μM. LibDock displayed that benzenesulfonamides can form hydrophobic interactions with the side
chains of Leu129, Cys13, Ala202, Val198, Leu217 and Ile215 and participate in п-п stacking with Phe441, Phe197
and Arg201 in the binding pocket of CETP.

Conclusion:
Pharmacophore mapping showed significant matching with the pharmacophoric features of Hypo4/8
and shape-complemented Hypo4/8 of CETP inhibitors for potent compounds.
Detection of Iturin A from Bacillus atrophaeus by HPLC and Mass Spectrometry
Analysis and Evaluation of its Antifungal Activity
Authors: Pisheh Solmaz Moghtadi , Madani Mahboobeh , Shakib Pegah 
Published: June 2022

Background:
Bacillus species create several kinds of metabolites, which contain cyclic
lipopeptide-type antibiotics, consisting of three major families: fengycin, surfactin, and iturin. Iturin
demonstrates powerful biocontrol characteristics and can restrain the growth of a diversity of plant
fungal pathogens.

Objective:
The current study investigates the identification of iturin A from Bacillus atrophaeus using
HPLC and Mass spectrometry analysis and evaluate its antifungal effects.

Materials and Methods:
In this study, the lipopeptide antibiotics were isolated by HPLC and characterized
by MS. Then, the lipopeptides were examined for their ability to antagonize the growth of different
pathogenic fungi. Antifungal performance of the lipopeptides was determined against Fusarium
oxysporum, Aspergillus niger, Penicillium chrysogenum, and Mucor hiemalis according to well diffusion
and percentage of growth inhibition.

Results:
Bacillus atrophaeus HNSQJYH170, isolated from Isfahan soil, offered strong fungicidal activity
by producing cyclic lipopeptide-type antibiotics. Inhibition zones were 17.55, 17, 18.50, and
20.99 mm, and the percentages of growth inhibition were 78.54, 62.55, 83.11, and 84/95 for Fusarium
oxysporum, Penicillium chrysogenum, Mucor hiemalis and Aspergillus niger, respectively. The spectrum
represented the iturins family in retention times of 32.423–33.893 min. MS demonstrated molecular
ion peaks (M+H) + for iturin at m/z 1029.55, 1043.60, 1051.55, 1065.60, 1079.60 and 1093.65.
The inhibition rate against all fungi on the seventh day of incubation was higher than 80%. Among
them, Aspergillus niger was the most sensitive fungal species with an average of 84.95% inhibition.

Conclusion:
According to the results, Bacillus atrophaeus HNSQJYH170 could operate as a biocontrol
agent against a wide spectrum of pathogenic fungi.
Efficacy and Safety of Lobaplatin-TACE in the Treatment of Primary Hepatocellular
Carcinoma: A Retrospective Study
Authors: Lu Haohao , Zheng Chuansheng , Liang Bin , Xiong Bin 
Published: June 2022

Purpose:
To investigate the safety and efficacy of lobaplatin-TACE in the treatment of primary hepatocellular carcinoma.

Method:
The data of 536 patients who underwent TACE in the interventional department from January 2016 to January 2020 were collected. Patients were divided into two groups according to the chemotherapeutic drugs used in TACE.: epirubicin-TACE group(N = 260), lobaplatin-TACE group(N = 276). Primary study endpoint: (1) The tumor response after TACE; (2)The survival rates ; Secondary study endpoints:(1)Changes of liver function and blood routine before and after TACE;(2)Occurrence of post-embolization syndrome and infection after TACE.

Results:
The ORR was 35.0% in epirubicin-TACE group and 51.1% in lobaplatin-TACE group(P=0.001). The DCR was 73.1% in epirubicin-TACE group and 82.2% in lobaplatin-TACE group(P=0.011). The 6-month, 9-month, 12-month, and 15-month survival rates were higher in the lobaplatin-TACE group than in the epirubicin-TACE group(P=0.029,P=0.001,P=0.005,P=0.002). mOS: Epirubicin-TACE group,14.8 months; Lobaplatin-TACE group,18.6 months (P =0.007). mPFS: Epirubicin-TACE group,9.5 months; Lobaplatin-TACE group,12.8 months (P =0.000). There was no statistical difference in ALT, AST, total bilirubin and Leucocyte after TACE between the two groups (P=0.343,P=0.368,P=0.288,P=0.359). The platelet decrease after TACE was more significant in the lobaplatin-TACE group than in the epirubicin-TACE group (P=0.046). There was no statistical difference in the incidence rate of abdominal pain, fever and infection after TACE between the two groups (P=0.502,P=0.602,P=0.726).The incidence of vomiting after TACE in the lobaplatin-TACE group was higher than that in the epirubicin-TACE group (P=0.003).

Conclusion:
Lobaplatin-TACE has higher tumor response rate and survival rate.Lobaplatin-TACE is a safe and effective treatment strategy,it is worthy of clinical application.
Cannabidiol Successful Therapy for Developmental and Epileptic Encephalopathy Related to CYFIP2
Authors: de Góes Fernanda Veiga , de Andrade Ramos Jessyca Thays Melo , da Silva Fontana Rosiane , de Carvalho Serão Cassio Luiz , Kok Fernando , Gandelman Horovitz Dafne Dain 
Published: June 2022

Background:
The knowledge about the molecular basis of epilepsies has increased enormously with the advent of next-generation sequencing (NGS) technology, and CYFIP2 is one of the many genes recently recognized and associated with epilepsy. Pathogenic variants in CYFIP2 cause Developmental and Epileptic Encephalopathy 65 (DEE65), which is characterized by hypotonia, profound developmental delay, and epilepsy.

Case Presentation:
Herein, we report a 3-year-old male with an early onset epileptic encephalopathy (Ohtahara syndrome) evolving to Lennox-Gastaut syndrome refractory to several antiseizure medications. Whole exome sequencing (WES) disclosed a heterozygous pathogenic variant p.(Arg87Cys) in CYFIP2, which occurred as a de novo event. After the introduction of cannabidiol, the patient remained seizure-free for 16 months and had a marked electroencephalographic improvement.

Conclusion:
Cannabidiol might be a therapeutic option for CYFIP2-related epilepsy
General Practitioners’ Experiences of Professional Uncertainties Emerging from the Introduction of Video Consultations in General Practice: Qualitative Study
Authors: Nordtug Maja , Assing Hvidt Elisabeth , Lüchau Elle Christine , Grønning Anette 
Published: June 2022

BackgroundUncertainties are omnipresent in health care, but little is known about general practitioners’ (GPs) professional uncertainties concerning digital consultations. This is problematic, as many countries have undergone an extensive digital transformation.ObjectiveThe aim of this study was to explore the professional uncertainties that emerged among Danish GPs with the introduction of video consultations.MethodsWe conducted qualitative interviews with 15 Danish GPs during the beginning of the COVID-19 pandemic in 2020. The interviews were analyzed using an abductive approach.ResultsWe identified 3 categories of uncertainty: integrity, setting, and interaction. Respectively, these 3 categories of uncertainty refer to (1) uncertainties related to how technology may impede the provision of health care; (2) uncertainties related to the potentials of video technology; and (3) uncertainties related to how the video consultation technology affects interactions with patients.ConclusionsThe uncertainties experienced by Danish GPs appear to be a typical reaction to the introduction of new technology. Embedding video consultation technology into GPs’ working routines will take time, and GPs do not necessarily feel intuitively capable of transferring their abilities, such as being good and socially present for video-mediated consultations. The heterogeneity of professional uncertainties experienced among the GPs suggests that they are the product of individual GP-technology relationships—not of the technology in itself. Consequently, we cannot expect that uncertainties can be remedied by changing or precluding new technology.
La otra escuela. Estrategias y materiales didácticos digitales antes y después del Covid-19, un estudio de caso
Authors: Sequera Aguilar Elizabeth Josefina 
Published: June 2022

Cuando se hace referencia a la otra escuela donde la tecnología podría considerarse un medio y no el fin, sabríamos pensar e imaginar la escuela digital, sin espacio físico, conectada con muchos, flexible, colaborativa de estrategias y materiales didácticos trascendentales para la transformación del aprendizaje tradicional.

El objetivo de este estudio comparativo de casos fue analizar las estrategias y los materiales didácticos digitales utilizados por un grupo de docentes venezolanos antes y después de la llegada del Covid-19. Esta investigación cualitativa se apoyó en el análisis de contenido como metodología, para ello se aplicó una entrevista en profundidad a 36 docentes vía telefónica a raíz de la propagación de virus Covid-19.
Los hallazgos revelaron un antes y un después de la pandemia en cuanto a el uso de estrategias y materiales digitales. No obstante, la escuela no puede permanecer al margen de esta realidad a pesar de los cambios llegada la pandemia, aún falta mucho por hacer para materializar la otra escuela.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE MAKE A MATCH TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN IPA KELAS IV SDN 3 KERTASURA
Authors: Caswati Caswati 
Published: June 2022

Abstract: Energy sources are one of the learning materials that must be mastered by elementary school students. Many benefits are generated from the material, but students have not obtained it optimally because the average student score is less than the KKM. The other influence is the use of the learning model that is applied is not appropriate. This study aims to determine the effect of the Make a Match cooperative learning model on student learning outcomes in science subjects in grade IV at SDN 3 Kertasura. In this study using a quasi-experimental method. The population of this study were all fourth grade students at SDN 3 Kertasura with a total of 40 students, of which 20 samples of class IVa as the experimental class and 20 samples of class IVb as the control class. Data analysis was carried out quantitatively. Quantitative analysis was carried out through the t-test with a significance level of 0.05 or 5%, meaning that if the significance value of tcount > ttable states Ha is accepted and Ho is rejected, it means that there is a significant effect between the independent variable and the dependent variable. Based on the processed data, it was found that the cooperative learning model of Make a Match type had a significant effect on student learning outcomes in the Make a Match type of cooperative learning in class IV at SDN 3 Kertasura. Keywords: Learning Outcomes, Make a Match Type Cooperative Learning Model, Grade IV Elementary School. Abstrak: Sumber energi merupakan salah satu materi pembelajaran yang wajib di kuasai siswa SD. Banyak manfaat yang dihasilkan dari materi tersebut, namun siswa belum memperolehnya dengan maksimal karena rata-rata nilai siswa kurang dari KKM. Adapun pengaruh lainya yaitu penggunaan model pembelajaran yang diterapkan kurang tepat. Penelitian ini bertujuan mengetahui pengaruh model pembelajaran Kooperatif tipe Make a Match terhadap hasil belajar siswa pada mata pelajaran IPA di kelas IV SDN 3 Kertasura. Pada penelitian ini menggunakan metode kuasi eksperimen. Populasi penelitian ini seluruh siswa kelas IV SDN 3 kertsura dengan jumlah 40 siswa yang mana 20 Sampel kelas IVa sebagai kelas eksperimen dan 20 sampel kelas IVb sebagai kelas kontrol. Analisis data di lakukan secara kuantitatif. Analisis kuantitatif dilakukan melalui uji t dengan taraf signifikansi ∞ 0,05 atau 5% artinya apabila nilai signifikansi thitung > ttabel menyatakan Ha diterima dan Ho ditolak, artinya terdapat pengaruh yang signifikan antara variabel bebas dengan variabel terikat. Berdasarkan olahan data diperoleh temuan, bahwa model pembelajaran kooperatif tipe Make a Match berpengaruh secara signifikan terhadap hasil belajar siswa pada mata pelajaran Kooperatif tipe Make a Match di kelas IV SDN 3 Kertasura. Kata Kunci : Hasil Belajar, Model Pembelajaran Kooperatif Tipe Make a Match, kelas IV SD.
Pancreaticopleural fistula in a Thai boy with SPINK1 c.101A>G substitution variant-related chronic pancreatitis: a case report and literature review
Authors: Chittchang Chomanad , Netinatsunton Nisa , Kritsaneepaiboon Supika 
Published: June 2022

Abstract

Background
Chronic pancreatitis is the most common etiology of pancreaticopleural fistula (PPF) in children, and underlying genetic variations are now widely known, accounting for most chronic pediatric pancreatitis.

Case report
We describe a case of previously undetected chronic pancreatitis and PPF with a SPINK1 variation in a 10-year-old Thai boy who presented with massive left pleural effusion. Magnetic resonance cholangiopancreatography (MRCP) revealed disruption of the pancreatic duct, which was communicating with a large pancreatic pseudocyst with mediastinal extension. The patient subsequently underwent endoscopic intervention with improved clinical symptoms. We also reviewed the imaging findings of 12 other reported cases of pediatric PPF.

Conclusions
Massive pleural effusion due to PPF can be an atypical manifestation in children with chronic pancreatitis. MRCP is the preferable imaging study for PPF due to the production of highly detailed images of pancreatic duct disruptions and anatomy, and the imaging is helpful to guide for appropriate treatment. Tests for genetic variation are also recommended in a child with chronic pancreatitis.
Educational Communication and Stress at Preschool and Primary Teachers in the Educational Pandemic Context
Authors: Vlaicu Claudia , Dinu Beatrice-Alina , Alecu Denisa-Flavia 
Published: June 2022

Abstract
In the pandemic context, both stress and educational communication have been altered.
In this article, we will analyse the dynamics of the factors involved in didactic communication and identify the real and potential stressors for teachers teaching before pandemic; we will also assess their perceptions of the anxiety felt about online teaching and how it affects educational communication. The hypothesis of the research postulates that the stress perceived by the teachers has elevated during pandemic and the educational communication has gone through a series of changes and reorientations both at the level of the didactic strategies adopted and the regulation of anxiety factors involved (the feeling of safety, the perception of break as a stress factor instead of relaxation, the volume of tasks attributed to each teacher etc).
The research variables were the pandemic context in school environment, the level of stress as perceived by the teachers and the educational communication.
The research objectives were aimed at assessing the perception of teachers in rural areas vs. that of teachers in urban areas regarding the stress felt and the dynamics of educational communication; also comparing the stress felt by teachers and the dynamics of educational communication incumbents vs. substitutes, educators vs. teachers and teachers in rural areas vs. urban teachers.
We expect that the results of the research would have therefore a more assumed awareness from school managers of the fact that there are many predictors of stress that should no longer be ignored and that raising teacher’s resilience both at personal level and academic one should become a priority. School managers should organize mindfulness courses and anxiety management courses for teachers.
Effects of Student’s Use of Social Media on Academic Performance (A case study of Secondary School students in Onitsha)
Authors: Ejoh Nonso , Lawan Mujtaba 
Published: June 2022

Abstract
The impact of social media use on academic achievement in science subjects among senior secondary school students in Anambra State, Nigeria, was studied using a descriptive survey design. The study’s goals are to determine the relationship between social media usage and academic performance in science subjects among Anambra State Senior Secondary School students, as well as to determine whether there is a difference in the relationship between social media usage and academic performance in science subjects between male and female Anambra State Senior Secondary School students. The study’s participants are all Senior Secondary School students in Onitsha, Anambra State. The population in its entirety is 1,450. According to the research advisers’ requirements, the study’s sample size is two hundred and sixty (260) senior secondary school students from Onitsha North and South. To test hypothesis one, the data was analyzed using Pearson product moment correlation (r). The use of PPMC was based on the assumption that it can be used to form relationships. Because hypothesis two had multiple independent variables, regression analysis was utilized to test them. There is no significant association between social media usage and Academic Performance in Science Subjects among Anambra State Senior Secondary School Students, although there is a significant difference between male and female Senior Secondary School Students in Anambra State. The following recommendations were made based on the study’s findings: teachers should encourage students to use social media positively for academic activities, teachers and school counselors should treat both male and female students with social media disorder equally, adequate ICT facilities should be provided to both local governments, and secondary school teachers should use the same motivational measures for using social media for academic purposes.
Exposure as a Method to Experiencing Hospitality in Education
Authors: Nielsen Susanne Buch , Volsing Ellen Louise , Marin Elena 
Published: June 2022

Abstract
There is increasing pressure for all education institutions to undergo transformation, with education as needing to adapt in ways that meet the conceptual needs of our time. Reflecting this is the educators’ role in the classroom. The purpose of this scoping review is to provide a comprehensive overview of relevant research regarding the emergence of different kind of creative and innovative methods used by educators at all levels – and the links to including pedagogy. The scoping review is underpinned by the framework of Arksey & O`Malley (2005) that offers a new approach by including a consultation exercise in this sort of study that may enhance the results, making them more useful to policy makers, practitioners and service users. The results indicate that there is much indirect evidence emerging of improved academic performance and student and staff satisfaction with methodologies connected to or compared with what we call exposure methods. The literature points out, that exposure is coherent to aesthetic performance such as drama and applied aesthetics may lead to practical ethics. It is evident that methodologies connected to exposure have a significant impact on people involved – both educators and students.
Barriers of the Use of ICT in Teaching: Mont-Amba Educational Province Solutions
Authors: Benjamin Manda Kisimba , Baudoin Mbaruku Ramazani , Jean-Pierre Kalay Kut 
Published: June 2022

AbstractThe accelerated advancement of the technological revolution in the new digital world forces teachers to adapt and renovate their teaching practice by using information and communication technologies in the usual way so that this innovation improves the quality of the teaching and learning for skills development through the effective use of these technologies. Thus, teachers face many challenges when trying to integrate technology into their classrooms. Teachers from the Mont-Amba Educational Province, for example, are not spared from the many obstacles they face to use technologies in teaching and learning. It is within this framework that this research has set itself the main objective of investigating the challenges of using ICT in teaching and learning in order to propose solutions to improve the practices of teaching and learning in elementary schools in the educational province of Mont-Amba.The research used a descriptive statistical analysis based on a mixed approach, and a conceptual framework was developed to guide the research. The sample of the target population is composed of 80 Teachers and 5 Head Teachers; two instruments, questionnaire and interview, are used to collect data. Qualitative data were analyzed by SPSS, and qualitative data were coded and analyzed. After analyzing the data, the result reveals that teachers face several challenges, such as lack of effective training, lack of resources, lack of time, lack of technical support and leadership, lack of knowledge and skills, lack of internet, lack of electricity, technical breakdown, low government funding, and lack of an effective strategy of ICT use in teaching and learning.Originality or value: this study is very significant at two levels. First, in the scientific context, it contributes to the scientific literature on the use of ICTs in education. Secondly, it clarifies the barriers to the use of ICT in primary school teaching and learning that teachers face, and this study has developed a series of recommendations that will be presented to the government and the administrative authorities of the Congolese education sector so that it applies to meet these different challenges in the use of ICT in this educational province.
Siauw Giok Tjhan and Abdurrahman Wahid: History of Chinese Citizenship in Indonesia
Authors: Fikri Asyrul , Hasudungan Anju Nofarof 
Published: June 2022

Abstract
This study aims to describe the role of Siauw Giok Tjhan and Abdurrahman Wahid in mainstreaming the discourse of ethnic Chinese citizenship into an integral part of the Indonesian nation. This study uses historical research methods. The results showed that Siauw Giok Tjhan through Baperki (Indonesian Citizenship Consultative Body) an organization founded in 1954 had helped ethnic Chinese from discriminatory policies in order to obtain Indonesian citizen status (WNI). Siauw Giok Tjhan suggested that the ethnic Chinese should carry out a proper integration into the Indonesian nation-society. Through the concept of fair integration, Siauw Giok Tjhan tries to instill awareness in the ethnic Chinese about their Indonesian identity and nation building. However, the political changes after the G30S 1965 have become a setback for the ethnic Chinese to integrate. When Abdurrahman Wahid was president, various policies were carried out to assist ethnic Chinese in the integration process and eliminate discriminatory policies. The strengthening of identity politics today is also due to the absence of these two national figures.