bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathologische Gefäßkalzifizierung – klinische
Relevanz und molekulare Mechanismen
Authors: Hense Nicolas , Goettsch Claudia 
Published: December 2022

ZusammenfassungDie kardiovaskuläre Kalzifizierung stellt als pathologische
Mineralablagerung in Herzklappen und Arterien einen Prädiktor und
Risikofaktor für die kardiovaskuläre Morbidität und
Mortalität dar – ein globales Gesundheitsproblem. Die
kardiovaskuläre Kalzifizierung ist ein ‚Unmet need‘ in
der kardiovaskulären Medizin, da es bisher keine therapeutischen
Ansatzpunkte gibt, die diesen Prozess aufhalten oder modifizieren
können. Diese Übersichtsarbeit fasst die Manifestationsformen
der kardiovaskulären Kalzifizierung mit ihren klinischen Relevanzen
zusammen. Dabei wird der Fokus insbesondere auf die arterielle
Mikrokalzifizierung der Tunica intima, sowie Makrokalzifizierung der Tunica
media und der Aortenklappe gelegt. Die zellulären und molekularen
Mechanismen, die die kardiovaskuläre Kalzifizierung regulieren, sind
vielfältig und zeigen Parallelen zum Knochenstoffwechsel. Neben den
klassischen Signalwegen, wird die Rolle epigenetischer Veränderungen
diskutiert. Letztlich werden offene Fragen aufgezeigt, deren Beantwortung
wichtig ist, um Therapieansätze zur Prävention und Behandlung
kardiovaskulärer Kalzifizierung entwickeln zu können, die die
Knochengesundheit nicht beeinflussen.
Verlaufsuntersuchung der lumbalen Bandscheiben- und Facettengelenkveränderungen bei 5 Deutschen Schäferhunden
Authors: Paulus Christiane , Brinkmeier Hannah Sofie , Jährig Rodja Aljoscha , Schaub Katharina Isabell , Büttner Kathrin , Kramer Martin , von Pückler Kerstin 
Published: December 2022

Zusammenfassung
Gegenstand und Ziel In dieser Langzeitbeobachtungsstudie sollten erstmals die Veränderungen der kaudalen Lendenwirbelsäule an den Lokalisationen L5/6, L6/7 und L7/S1 bei 5 Deutschen Schäferhunden im Abstand von 6 Jahren mithilfe der Computertomografie (CT) und Magnetresonanztomografie (MRT) evaluiert werden. Die Hunde waren zum Zeitpunkt der ersten Untersuchung im Mittel 26 Monate alt. Zudem wurde evaluiert, ob eine Zuchtuntersuchung im Hinblick auf eine Bandscheibendegeneration beim Junghund zielführend ist.
Material und Methoden Die Bandscheiben von L7/S1, L6/7 und L5/6 wurden im Hinblick auf ihre Signalintensitätsveränderung, die Facettengelenkwinkelveränderungen in dorsaler und transversaler Schnittebene sowie die Veränderungen der Bandscheibenfläche in sagittaler und transversaler Rekonstruktionsebene im Jahr 2015 und 2021 mittels CT und MRT genauer untersucht. Alle Daten wurden computergestützt erhoben und statistisch ausgewertet und anschließend mit der gemessenen Signalintensität sowie mit der in der Praxis verwendeten, subjektiven Bandscheibendegenerationseinteilungen nach Seiler verglichen.
Ergebnisse Es zeigte sich ein signifikanter Verlust der gemessenen Signalintensität der Bandscheiben in der transversalen Schnittebene sowie insgesamt eine Facettengelenkerweiterung in der transversalen Ebene von 0,54° sowie in der dorsalen Ebene von 1,8° im Zeitraum von 6 Jahren. Des Weiteren ergaben sich keine Hinweise auf einem Zusammenhang zwischen der Größe des Facettengelenkwinkels und dem Bandscheibendegenerationsgrad. Darüber hinaus wiesen die Bandscheiben unabhängig vom initialen Degenerationsgrad in der Verlaufskontrolle eine geringe Signalintensität und einen höheren Seiler Grad auf.
Schlussfolgerung und klinische Relevanz Die Ergebnisse der vorliegenden Untersuchungsgruppe weisen darauf hin, dass ein unauffälliger Zustand der lumbalen Bandscheiben zum Zeitpunkt der Zuchtuntersuchung im Junghundehalter keine genaue Voraussage über den späteren Degenerationsgrad zulässt und es auch bei gesunden Deutschen Schäferhunden an den Facettengelenken zu fortwährenden Umbauprozessen kommt.
Advances in Organoid Culture Research
Authors: Xie Zhiyuan , Wang Linghao , Zhang Yan 
Published: December 2022

AbstractOrganoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments because they mimic the structural and functional characteristics of organs. However, the full potential of organoids in research has remained unrealized and the clinical applications have been limited. One of the reasons is organoids are most efficient grown in reconstituted extracellular matrix hydrogels from mouse-derived, whose poorly defined, batch-to-batch variability and immunogenicity. Another reason is that organoids lack host conditions. As a component of the tumor microenvironment, microbiota and metabolites can regulate the development and treatment in several human malignancies. Here, we introduce several engineering matrix materials and review recent advances in the coculture of organoids with microbiota and their metabolites. Finally, we discuss current trends and future possibilities to build more complex cocultures.
Substrate Rigidity Effect on CAD/CAM Restorations at Different Thicknesses
Authors: Pucci César Rogério , Mafetano Ana Paula Valente Pinho , Borges Alexandre Luiz Souto , de Andrade Guilherme Schmitt , Dal Piva Amanda Maria de Oliveira , Kleverlaan Cornelis J. , Tribst João Paulo Mendes 
Published: December 2022

Abstract
Objectives This article evaluated the effect of substrates rigidities on the post-fatigue fracture resistance of adhesively cemented simplified restorations in lithium disilicate glass ceramic.
Methods Precrystalized computer-aided design/computer-aided manufacturing ceramic blocks were processed into disc-shaped specimens (n = 10, Ø = 10 mm), mimicking a simplified restoration at two thicknesses (0.5 and 1.0 mm). Thereafter, the discs were cemented onto different base substrates (dentin analogue [control], dentin analogue with a central core build-up of resin composite [RC], or glass ionomer cement [GIC]). The specimens were subjected to mechanical cycling in a chewing simulator (100 N, 1 × 106 cycles, 4 Hz) and then subjected to thermocycling aging (10,000 cycles, 5/37/55°C, 30 seconds). After the fatigue protocol, the specimens were loaded until failure (N) in a universal testing machine. Finite element analysis calculated the first principal stress at the center of the adhesive interface.
Results The results showed that “restoration thickness,” “type of substrate,” and their interaction were statistically significant (one-way analysis of variance; p < 0.001). Regardless the restoration thickness a higher fracture load was observed for specimens cemented to dentin analogue. Among the base materials, RC build-up presented the highest fracture load and lower stress magnitude for both restoration thicknesses in comparison with GIC build-up. The 0.5-mm restoration showed higher stress peak and lower fracture load when submitted to the compressive test.
Conclusion More flexible base material reduces the fracture load and increases the stress magnitude of adhesively cemented lithium disilicate restorations regardless the ceramic thickness. Therefore, more rigid substrates are suggested to be used to prevent restoration mechanical failures.
A Nationwide Analysis Evaluating the Safety of Using Acellular Dermal Matrix with Tissue Expander-Based Breast Reconstruction
Authors: Luo Jessica , Moss Whitney D. , Pires Giovanna R. , Rhemtulla Irfan A. , Rosales Megan , Stoddard Gregory J. , Agarwal Jayant P. , Kwok Alvin C. 
Published: December 2022

Abstract
Background In March 2021, the United States Food and Drug Administration (FDA) safety communication cautioned against the use of acellular dermal matrix (ADM) products in breast reconstruction and reiterated that the FDA does not approve ADM use in breast surgery. This study aims to assess the safety of ADM use in breast reconstruction.
Methods Women who underwent ADM and non-ADM assisted tissue expander (TE)-based breast reconstruction were identified using the National Surgical Quality Improvement Program database (2012–2019). Trends of ADM use over time, and 30-day outcomes of surgical site infection (SSI), dehiscence, and unplanned reoperation were assessed.
Results Of the 49,049 TE-based breast reconstructive cases, 42.4% were ADM assisted and 57.6% non-ADM assisted. From 2012 to 2019, the use of ADM increased from 26.1 to 55.6% (relative risk [RR] =1.10; p < 0.01). Higher rates of SSI (3.9 vs. 3.4%; p = 0.003) and reoperation (7.4 vs. 6.0%; p < 0.001) were seen in the ADM cohort. There was no significant difference seen in dehiscence rates (0.7 vs. 0.7%; p = 0.73). The most common reoperation within 30 days for the ADM group (17.6%) was removal of TE without insertion of implant (current procedural terminology: 11,971). ADM-assisted breast reconstruction was associated with increased relative risk of SSI by 10% (RR = 1.10, confidence interval [CI]: 1.01–1.21; p = 0.03) and reoperation by 15% (RR = 1.15, CI: 1.08–1.23; p < 0.001).
Conclusions ADM-assisted breast reconstruction more than doubled from 2012 to 2019. There are statistically higher complication rates of SSI (0.5%) and reoperation (1.4%) with ADM use in TE-based breast reconstruction, suggesting that reconstruction without ADM is safe when comparing immediate postoperative outcomes.
Bibliometric research of the Pay-What-You-Want Topic
Authors: Vizuete-Luciano Emili , Güzel Oktay , Merigó José M. 
Published: December 2022

AbstractPay-What-You-Want (PWYW), is a pricing strategy increasingly applied in many different industries, both profitable and not. This study aims to identify influential cited works in PWYW research, determine the current status, and indicate the extent to which influential works have shaped the field addressing this concern, a set of bibliometric analyses conducted in this paper. The analysis was carried out on 136 research papers published between 2009 and 2022 have been analyzed based on Web of Science Core Collection (WoS) results. In order to identify the most cited authors and works, the co-citation analysis was applied. To scrutinize the intellectual structure of the field, bibliometric coupling was applied, to show the network structure of the themes, co-word analysis was applied. Building upon the results, this study suggests future research paths.
Friends, food or worth fighting for? A proposed stereotype content model for nonhuman animals
Authors: Patinadan Paul V. , Dillon Denise B. 
Published: December 2022

Abstract
The human perception of nonhuman animals is a burgeoning area of anthrozoology, with the past decade seeing an increase in work within the field. This study attempted to assess people’s social perceptions about various nonhuman animals. Food animals, for example, have often been classified as being less sentient and have been historically devoid of rights and moral concern due to their nature as a consumable commodity. Advancements in social psychology have allowed the general hypothesis that some key theories might be transferrable toward understanding how people perceive animals. This study borrows from work on the Stereotype Content Model (SCM) and attempts to replicate the social perceptions of animals along the warmth-competence dimensions among a Singaporean sample (N = 325) of vegetarians, animal activists, and those who regarded themselves as neither. Ratings on the scales of warmth and competence for 16 animals were subjected to multidimensional scaling analysis. Results indicate people hold different social perceptions congruent to the various animal species. Four main clusters were identified, and these were named, ‘Love’, ‘Save’, ‘Indifferent’, and ‘Dislike’ based on the expectancy of how participants might feel toward the animals. The ethical ideology of participants was also measured, with vegetarians and animal activists holding more ‘absolutist’ beliefs. When factored into the scaling process, ethical ideology had little impact on participants’ social perceptions of nonhuman animals.
Effects of magnesium oxide and copper oxide nanoparticles on biofilm formation of Escherichia coli and Listeria monocytogenes
Authors: Hashemifard Dehkordi Praisa , Moshtaghi Hamdollah , Abbasvali Maryam 
Published: December 2022

Abstract
Biofilms formed in food-processing environments are of special importance as they have the potential to act as a persistent source of microbial contamination that may lead to food spoilage or transmission of diseases. The creation of microbial biofilms, which can be a source of food product contamination with food spoilage and foodborne pathogenic bacteria, is one of the most critical elements in the food industry. The goal of this study was to see how well magnesium oxide (MgO) and copper oxide (CuO) nanoparticles (NPs) inhibited growth and biofilm formation of two common foodborne bacterial pathogens. This study was completed in the year 2020. Resazurin reduction and micro-dilution procedures were used to assess the minimum inhibitory concentration (MIC) of magnesium oxide and copper oxide nanoparticles for Escherichia coli O157: H7 (ATCC 35 218) and Listeria monocytogenes (L. monocytogenes) (ATCC 19 118). The bacterial adhesion to hydrocarbon technique was used to determine the cell-surface hydrophobicity of the selected bacteria. The surface assay was also used to calculate the influence of the NPs coated surfaces on the biofilm formation of the selected bacteria. Magnesium oxide nanoparticles had MICs of 2 and 2 mg ml−1, while copper oxide nanoparticles had MICs of 0.16 and 1 mg ml−1 against E. coli and L. monocytogenes, respectively. At the MIC, the magnesium and copper nanoparticles inhibited biofilm formation of E. coli and L. monocytogenes by 89.9 and 96.6 percent and 93.6 and 98.7 percent, respectively. The hydrophobicity of E. coli and L. monocytogenes was determined to be 74% and 67%, respectively. The surface assay revealed a substantial reduction in bacterial adhesion and colonization on NPs-coated surfaces. Both compounds had inhibitory effects on E. coli and L. monocytogenes, according to our findings. Even at sub-MICs, NPs were found to be able to prevent biofilm development. The microbial count and production of microbial biofilms were reduced on surfaces coated with MgO and CuO nanoparticles. MgO and CuO nanoparticles can be utilized as a cleaning agent for surfaces to avoid the formation of foodborne bacterial biofilms, which is important for public health.
The eigenvalues and eigenfunctions of the toroidal dipole operator
Authors: Anghel Dragoş-Victor , Dolineanu Mircea 
Published: December 2022

Abstract
The toroidal dipole represents the lowest order in the family of toroidal multipoles. They appear in physics at all scales, from particle to condensed matter physics, and metamaterials. Nevertheless, in small systems they have to be investigated in the context of quantum mechanics and quantum operators are introduced for the projections of the toroidal dipole on the Cartesian axes. Here we give analytical expressions for the eigenvalues and generalized eigenfunctions of

T

ˆ

3

–the z-axis projection of the toroidal dipole operator–in a system consisting of a particle confined in a thin film bent into a torus shape. The eigenfunctions are not square integrable, so they do not belong to the Hilbert space of wave functions, but they can be interpreted in the formalism of rigged Hilbert spaces as kernels of distributions. We find the quantization rules for the eigenvalues, which are essential for describing measurements of

T

ˆ

3

. As an example, we estimate the splitting of the energy levels due to the interaction of the toroidal dipole with an external current.
Study of the pressure effect on the thermodiffusion behavior in multicomponent n-alkane mixtures by using non-equilibrium molecular dynamics
Authors: Chen Xiaoyu , Liu Bo , Liang Ruquan , Xiao Song 
Published: December 2022

Abstract
The influence of high pressure on the Soret effect of multicomponent n-alkanes mixtures was investigated with the non-equilibrium molecular dynamics method to provide simulation support to the SJ10/SCCO experiments. In this work, n-pentane/n-heptane/n-decane ternary mixtures and methane/n-pentane/n-heptane/n-decane quaternary mixtures were built and simulated under the same situations as the space experiments. TraPPE-UA force field and eHEX algorithm were employed in Soret effect simulations, and three different amounts of heat (ΔQ) were applied in each mixture. The simulated thermodiffusion ratios (k

T
) were compared with the data from other literature. In ternary mixtures, the k

T
values were influenced by the pressure, but the migration directions and separation relationship of the components did not change. While in quaternary mixtures, the strong and weak separation relationships of the two lowest separated components changed. The results demonstrated that the high pressure weakens the Soret effect in multicomponent n-alkane mixtures to an extent and may affect more in the mixture composed of more components.
Resonance characteristics and energy losses of an ultra-high frequency ZnO nanowire resonator
Authors: Cai Xianfa , Xu Lizhong 
Published: December 2022

Abstract
An ultra-high frequency (UHF, 300 MHz∼3 GHz) nano mechanical resonator based on defect-free zinc oxide nanowire (ZnO NW) was fabricated through a top-down processing method. Using UHF detection technology based on a lock-in amplifier, through optimized measurement of high-performance equipment, it was detected at room temperature that the ZnO NW resonator could operate at a resonance frequency of nearly 650 MHz and a quality factor Q ≈ 1000∼2500, and its force sensitivity could reach 1 f N·Hz−1/2. The deformation, driving force and first-order resonance frequency of the resonator were calculated using the continuum model and compared with the experimental data. The resonance characteristics of ZnO NW resonators under piezoelectric excitation were analyzed and compared with that under electromagnetic excitation. The effects of various loss factors on the resonance characteristics were analyzed, with emphasis on the generation mechanism of piezoelectric loss, clamping loss and eddy current loss and their effects on quality factor and force sensitivity. The ZnO NWs used in this paper have piezoelectric effect, which is rare in other NWs, and are difficult to be fabricated in a bottom-up manner. And experiments show that for ZnO NWs resonators, piezoelectric excitation has obvious advantages in Q value compared with electromagnetic excitation. Unlike the bottom-up wet etch processing method, the resonant beam structure is well protected by the top-down processing method to reduce internal defects, and the top-down fabrication method is easier to integrate into the fabrication process of integrated circuits, which provides great potential for the applications of NW resonators, such as quantum electromechanical systems and high-frequency signal processing.
Learning in a closed-loop brain-machine interface with distributed optogenetic cortical feedback
Authors: Goueytes Dorian , Lassagne Henri , Shulz Daniel E , Ego-Stengel Valérie , Estebanez Luc 
Published: December 2022

Abstract

Objective. Distributed microstimulations at the cortical surface can efficiently deliver feedback to a subject during the manipulation of a prosthesis through a brain-machine interface (BMI). Such feedback can convey vast amounts of information to the prosthesis user and may be key to obtain an accurate control and embodiment of the prosthesis. However, so far little is known of the physiological constraints on the decoding of such patterns. Here, we aimed to test a rotary optogenetic feedback that was designed to encode efficiently the 360° movements of the robotic actuators used in prosthetics. We sought to assess its use by mice that controlled a prosthesis joint through a closed-loop BMI. Approach. We tested the ability of mice to optimize the trajectory of a virtual prosthesis joint in order to solve a rewarded reaching task. They could control the speed of the joint by modulating the activity of individual neurons in the primary motor cortex. During the task, the patterned optogenetic stimulation projected on the primary somatosensory cortex continuously delivered information to the mouse about the position of the joint. Main results. We showed that mice are able to exploit the continuous, rotating cortical feedback in the active behaving context of the task. Mice achieved better control than in the absence of feedback by detecting reward opportunities more often, and also by moving the joint faster towards the reward angular zone, and by maintaining it longer in the reward zone. Mice controlling acceleration rather than speed of the joint failed to improve motor control. Significance. These findings suggest that in the context of a closed-loop BMI, distributed cortical feedback with optimized shapes and topology can be exploited to control movement. Our study has direct applications on the closed-loop control of rotary joints that are frequently encountered in robotic prostheses.
Assessment of distributed new energy-bearing capacity of new power systems with multisource complementary characteristics
Authors: Li Jifeng , Liang Xianming , Wang Yanbo , He Xingtang , Pan Feng , Wu Jun 
Published: December 2022

Abstract
A reasonable assessment of the bearing capacity of distributed power-generation sources in power systems is a key guarantee for the construction of new power systems with new energy sources as the core. In view of the fact that the current distributed new energy-bearing capacity assessment method has not yet established a systematic assessment index system and has not taken into account multisource complementarity, a new distributed energy-bearing capacity assessment method for power systems that takes into account the characteristics of multisource complementarity was proposed. First, a distributed new energy-bearing capacity assessment framework was constructed and the influencing factors of distributed energy-bearing capacity were analysed. Second, a multidimensional distributed power bearing-capacity assessment index system and calculation method considering thermal stability, short-circuit current, voltage deviation, and harmonics was proposed and the assessment process of distributed energy-bearing capacity was proposed. Finally, the validity and applicability of the proposed method were verified through actual case simulation.
Application and Study of kiln temperature control system based on PLC
Authors: Zhao Jing , Wang Weijun 
Published: December 2022

Abstract
Kiln is a kind of main heat consuming equipment built with refractory materials to calcine materials and products. The temperature control of kiln directly affects the efficiency of the system, product quality and output. In order to produce the desired product output and quality, the kiln temperature must be controlled within a certain range to meet the process requirements. Due to the uncertainty and large lag of kiln temperature, the traditional control can not guarantee the constant temperature. Now taking the kiln temperature as the research object, the PID control based on PLC controller is adopted for the temperature. The results show that the PID kiln temperature control based on PLC has ideal effect and wide application prospect.
Insulation voltage experimental study of the galvanic couple in flow seawater
Authors: Ji Dou , Li Chen , Tong Yude 
Published: December 2022

Abstract
The problem of insulation voltage selection in potential-difference detection method of insulation performance of electrical insulating metal pair in flowing seawater is discussed. In flowing seawater, 921A-B10 pair was taken as the research object to design the insulation corrosion test of the pair material. The natural corrosion test, the galvanic corrosion test and the simulated electrical insulation test of the pair material were carried out respectively. The test shows that the larger the analog insulation resistance of the pair material in series is, the smaller the galvanic corrosion current is, and the larger the voltage at both ends of the insulation resistance is. Finally, the range of insulation setting voltage is obtained.