bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining curcumin and aspirin ameliorates preeclampsia‐like symptoms by inhibiting the placental TLR4/NF‐κB signaling pathway in rats
Authors: Ju Yaru , Feng Yan , Yang Yanjing , Hou Xiaolin , Zhang Xiaofeng , Zhu Xihui , Wang Yage , Yang Meiliu 
Published: October 2022

AbstractAimPreeclampsia (PE) is a common medical complication of pregnancy characterized by high blood pressure and proteinuria after the 20th gestational week. This study aimed to investigate the potency of the combination of curcumin and aspirin in the treatment of PE and explore the underlying mechanisms.Material and MethodsThe PE model was constructed in female rats by administering 0.5 mg/mL N‐nitro‐L‐arginine methyl ester from gestational days (GDs) 6 to 16. The pregnant female rats were divided into five groups according to the drug treatment. The curcumin or aspirin was given to the rats by tail vein injection (0.36 mg/kg) or gavage treatment (1.5 mg/kg BW/day) from GD4 to GD18.ResultsTreatment with curcumin and aspirin combination significantly reduced the systolic blood pressure and proteinuria in the PE rats. Meanwhile, in comparison to the PE rats treated with single‐dose curcumin or aspirin, the rats treated with combined curcumin and aspirin showed significantly decreased sFlt‐1, increased placental growth factor, and alleviated oxidative stress in both blood and placental tissues, which are abnormal in no‐treated PE rats. Furthermore, dramatically decreased inflammatory cytokines secretion and TLR4 and NF‐κB p65 expression in placental tissues were also observed in the PE rats with combined treatment compared to those of no‐treated, signal‐dose curcumin or aspirin‐treated PE rats.ConclusionsOur results suggested that the combined treatment of curcumin and aspirin significantly ameliorates the symptoms of PE in rats, which is most likely due to the inhibition of the placental TLR4/NF‐κB p65 signaling pathway.
Wear pattern‐associated color stability of prefabricated composite veneers versus ceramic veneers
Authors: Dederichs Marco , Viebranz Stephanie , An Hongseok , Guentsch Arndt , Kuepper Harald 
Published: October 2022

AbstractPurposeTo evaluate the effect of different surface wear patterns on the discoloration tendency of two different prefabricated composite veneers and lithium disilicate ceramic veneers.Materials and methodsDiscoloration tendency of two prefabricated composite resin veneers (Visalys Veneer Chairside (VIS) and Componeer (COM)) were compared to lithium disilicate veneers (IPS) in vitro. For each material, n = 60 samples were allocated to different test groups, and therefore each n = 10 specimens per group went through different wear tests. Mechanical abrasion tests were conducted using a toothbrush simulator, while erosive effects were carried out by citric acid (pH 1.57). A combination of abrasion and erosion tests was conducted as well. Four groups of wear tests were implemented: (1) abrasion, (2) abrasion followed by erosion, (3) erosion, and (4) erosion followed by abrasion. Another group was stored in distilled water as the control and one group was stained without a prior wear test. The staining solution was made from a coffee‐tobacco brew. Specimens were stored in the coffee‐tobacco solution for 21 days. Color measurements were performed with VITA Easyshade. To evaluate intramaterial discoloration, one half of every specimen was protected with foil. After storage in the staining solution, the first measurement was carried out on the ‘protected’ (untreated) surface, followed by a second measurement on the ‘processed’ (treated) discolored surface. Euclidean distance (ΔE) of discoloration was calculated according to the CIE‐L*C*h* system. Data were analyzed with ANOVA followed by Games‐Howell post hoc test and paired t‐test (α = 0.05).ResultsHighest changes in ΔE were found in COM after ‘abrasion’ (ΔE −2.55) and ‘erosion followed by abrasion’ (ΔE −1.41). The discoloration tendency of VIS was affected by all wear tests, but changes were below the perceptive threshold (ΔE −0.19–0.32). Only abrasion followed by erosion affected the discoloration of IPS significantly, but findings were below the perceptive threshold, as well (ΔE −0.09).ConclusionsPrefabricated composite resin veneers revealed a low level of discoloration tendency after different wear tests. Nevertheless, in most cases the lowest discoloration tendency was found in specimens made from lithium disilicate.
Safety, pharmacokinetics and antiviral activity of ABI‐H2158, a hepatitis B virus core inhibitor: A randomized, placebo‐controlled phase 1 study
Authors: Agarwal Kosh , Xu Jia , Gane Edward J. , Nguyen Tuan T. , Ding Yanhua , Knox Steven J. , Alves Katia , Evanchik Marc , Zomorodi Katie , Ma Julie , Yan Ran , Huang Qi , Colonno Richard , Stamm Luisa M. , Hassanein Tarek I. , Kim Dong Joon , Lim Young‐Suk , Yuen Man‐Fung 
Published: October 2022

AbstractTreatment for chronic hepatitis B virus infection (cHBV) is mostly indefinite, with new finite‐duration therapies needed. We report safety, pharmacokinetics and antiviral activity of the investigational HBV core inhibitor ABI‐H2158. This Phase 1a/b study (NCT03714152) had three parts: Part A, participants received a single ascending oral dose of ABI‐H2158 (5–500 mg) or placebo; Part B, participants received multiple doses of ABI‐H2158 300 mg once (QD) or twice (BID) daily or placebo, for 10 days; Part C, cHBV patients received ABI‐H2158 (100, 300, or 500 mg QD or 300 mg BID) or placebo, for 14 days. Ninety‐three participants enrolled. In Parts A/B, there were no serious adverse events (SAEs) or deaths, and all treatment‐emergent AEs (TEAEs) were Grade 1. In Part C, two patients had Grade 3 TEAEs unrelated to ABI‐H2158; there were no deaths, SAEs or Grade 4 TEAEs. In Part A, median time to maximum ABI‐H2158 plasma concentration (Tmax) and mean terminal elimination half‐life (t½) were 1–4 and 9.8–20.7 h, and area under the plasma concentration‐time curve increased dose proportionally. In Part B, Day 10 Tmax was 2 h, mean t½ was 15.5–18.4 h, and exposure accumulated 1.7‐ to 3.1‐fold. In Part C, Day 14 Tmax was 1 h, exposure accumulated 1.4‐ to 1.8‐fold, and ABI‐H2158 was associated with >2 log10 declines in HBV nucleic acids. In conclusion, ABI‐H2158 in cHBV patients following 14 days of dosing was well tolerated and demonstrated potent antiviral activity. Safety and pharmacokinetics supported future QD dosing.
Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats
Authors: Rozental Aaron J. , Gustafson Daniel L. , Kusick Breonna R. , Bartner Lisa R. , Castro Stephanie Cruz , McGrath Stephanie 
Published: October 2022

AbstractThis study aimed to assess the single‐dose pharmacokinetics and tolerability of a cannabidiol (CBD) isolate in sunflower oil with escalating oral doses in eight healthy, purpose‐bred cats. Eight cats were randomized into six dosing groups of four cats each. Cats were administered a single 2.5, 5, 10, 20, 40, or 80 mg/kg dose orally with at least a two‐week washout in between doses. Behavior scoring, complete blood count, serum biochemistry analysis, physical examination, and CBD plasma levels were evaluated before and after dosing. All cats successfully completed the study. CBD was measured in the plasma of all cats dosed with CBD oil. The Cmax and AUC increased in a dose‐proportional fashion across all dosing groups. There were no major bloodwork or behavioral changes although the BUN and creatinine values decreased after treatment across all doses. No adverse effects were observed, and behavioral changes were limited to head shaking, lip smacking, and hypersalivation immediately following dose administration. Single orally administered CBD doses up to 80 mg/kg were safe and well tolerated in this cohort of cats and display dose‐proportional pharmacokinetics across a broad concentration.
Use of thermal imaging and the photochemical reflectance index (PRI) to detect wheat response to elevated CO2 and drought
Authors: Mulero Gabriel , Jiang Duo , Bonfil David J. , Helman David 
Published: October 2022

AbstractThe spectral‐based photochemical reflectance index (PRI) and leaf surface temperature (Tleaf) derived from thermal imaging are two indicative metrics of plant functioning. The relationship of PRI with radiation‐use efficiency (RUE) and Tleaf with leaf transpiration could be leveraged to monitor crop photosynthesis and water use from space. Yet, it is unclear how such relationships will change under future high carbon dioxide concentrations ([CO2]) and drought. Here we established an [CO2] enrichment experiment in which three wheat genotypes were grown at ambient (400 ppm) and elevated (550 ppm) [CO2] and exposed to well‐watered and drought conditions in two glasshouse rooms in two replicates. Leaf transpiration (Tr) and latent heat flux (LE) were derived to assess evaporative cooling, and RUE was calculated from assimilation and radiation measurements on several dates along the season. Simultaneous hyperspectral and thermal images were taken at 1.5 m from the plants to derive PRI and the temperature difference between the leaf and its surrounding air (Tleaf−air). We found significant PRI and RUE and Tleaf−air and Tr correlations, with no significant differences among the genotypes. A PRI–RUE decoupling was observed under drought at ambient [CO2] but not at elevated [CO2], likely due to changes in photorespiration. For a LE range of 350 W m–2, the ΔTleaf−air range was 10°C at ambient [CO2] and only 4°C at elevated [CO2]. Thicker leaves in plants grown at elevated [CO2] suggest higher leaf water content and consequently more efficient thermoregulation at high [CO2] conditions. In general, Tleaf was maintained closer to the ambient temperature at elevated [CO2], even under drought. PRI, RUE, ΔTleaf−air, and Tr decreased linearly with canopy depth, displaying a single PRI‐RUE and ΔTleaf−air Tr model through the canopy layers. Our study shows the utility of these sensing metrics in detecting wheat responses to future environmental changes.
Gastrointestinal worms and bacteria: From association to intervention
Authors: Rooney James , Cantacessi Cinzia , Sotillo Javier , Cortés Alba 
Published: October 2022

AbstractA plethora of studies, both experimental and epidemiological, have indicated the occurrence of associations between infections by gastrointestinal (GI) helminths and the composition and function of the host gut microbiota. Given the worldwide risk and spread of anthelmintic resistance, particularly for GI parasites of livestock, a better understanding of the mechanisms underpinning the relationships between GI helminths and the gut microbiome, and between the latter and host health, may assist the development of novel microbiome‐targeting and other bacteria‐based strategies for parasite control. In this article, we review current and prospective methods to manipulate the host gut microbiome, and/or to exploit the immune stimulatory and modulatory properties of gut bacteria (and their products) to counteract the negative impact of GI worm infections; we also discuss the potential applications of these intervention strategies in programmes aimed to aid the fight against helminth diseases of humans and livestock.
Association between behavioural and psychological symptoms of dementia and residence status in patients with Alzheimer's disease
Authors: Midorikawa Haruhiko , Ekoyama Saori , Tachikawa Hirokazu , Ota Miho , Tamura Masashi , Takahashi Takumi , Sekine Aya , Ide Masayuki , Matsuzaki Asaki , Nemoto Miyuki , Nemoto Kiyotaka , Arai Tetsuaki 
Published: October 2022

AbstractBackgroundExamining the relationship between the behavioural and psychological symptoms of dementia (BPSD) and residence status is crucial to improving BPSD and reducing the burden on caregivers. However, studies on how BPSD differ between individuals living at home and those in institutional settings are lacking. We conducted a questionnaire survey among healthcare providers (HCPs) involved in dementia care and nursing to clarify the characteristics of BPSD by residence status in patients with Alzheimer's disease (AD) living at home or in facilities.MethodsWe sent questionnaires to HCPs and asked them to answer questions on up to five cases that needed treatment for BPSD and who received long‐term care insurance services from 1 April 2016 to 31 March 2017. Responses were received for 371 cases, of which 130 diagnosed with AD were analyzed. The patients were divided into two groups: patients with AD living at home (home care group) and patients with AD living in facilities (facility care group). A Chi‐square test was used to identify differences between the two groups. A binomial logistic regression analysis was also conducted to clarify the association between residence status and BPSD.ResultsOf the 130 patients, 72 lived at home (home care group) and 58 resided in facilities (facility care group). None of the background factors was significantly different between the two groups. The Chi‐square test indicated that sleep disturbance was significantly more common in the facility care group (60.3% in the facility care group vs. 33.3% in the home care group, P = 0.003), while the logistic regression analysis indicated that sleep disturbance was significantly associated with residence status (odds ratio: 2.529, P = 0.038).ConclusionsSleep disturbances were more frequently observed among patients with AD living in institutions than among those living in their homes.
What is the clinical relevance of deviant serum calcium and phosphate levels after pig‐to‐primate kidney xenotransplantation?
Authors: Lucander Aaron C. K. , Judd Eric , Cooper David K. C. 
Published: October 2022

AbstractExperience from human renal allotransplantation informs us that disturbances in serum calcium and phosphate levels are relatively common. Post‐transplant hypercalcemia is associated with an increased risk of recipient mortality, but not of graft loss or nephropathy, and post‐transplant hyperphosphatemia with an increased risk of both recipient mortality and death‐censored graft failure, but neither post‐transplant hypocalcemia nor hypophosphatemia is associated with adverse outcome.Studies after pig‐to‐nonhuman primate kidney xenotransplantation have demonstrated consistent supranormal serum calcium and subnormal serum phosphate levels. If these trends in serum electrolyte levels were to occur following pig‐to‐human kidney xenotransplantation, the data from allotransplant studies would indicate an increased risk of recipient mortality (associated with hypercalcemia) but not of graft loss or nephropathy, and no adverse outcome from hypophosphatemia.Furthermore, some nonhuman primates are now surviving in a healthy state for longer than a year after life‐supporting pig kidney transplantation, suggesting that chronic hypercalcemia and/or hypophosphatemia are not detrimental to long‐term survival, and should not prevent clinical trials of pig kidney transplantation from being undertaken.
New Optimized Dynamic Calibration Proposition for Discretized Sensorized Insoles With Resistive Force Sensor: A Descriptive and Comparative Study
Authors: Nascimento Diego Henrique Antunes , Magalhães Fabrício Anicio , Sabino George Schayer , Resende Renan Alves , Duarte Maria Lúcia Machado , Vimieiro Claysson Bruno Santos 
Published: October 2022

Abstract
Sensorized insoles (SIs) have been used as a wearable instrument to study human gait and have the potential to identify and predict pathologies and injuries. However, most of these sensorized insoles are only statically calibrated, relying on a scale and known weights to establish a relationship between electrical signals and the load applied on laboratory benches while ignoring the dynamic interaction between person and instrument. This study proposes and verifies a calibration method complementary to static calibration to compensate for different dynamic interactions between the insole and the individual during gait. In order to perform this comparison, a laboratory test was proposed with 32 volunteers (18 men and 14 women). Each volunteer walked on a double-belt instrumented treadmill (Bertec at 1000 Hz, Bertec Corp, Columbus, OH) while wearing an experimental resistive sensorized insole (SI). The SI data were compared with the instrumented treadmill and adjusted using an optimization algorithm to create a dynamic coefficient to complement and optimize the results. This study also verifies the impact of the method considering three different types of gait: pronated, neutral, and supinated. After using this technique and considering static calibration, the Pearson correlation coefficient between the SI and the instrumented treadmill improved by 12%.
Effect of Elongation of a Rod on Strain Inhomogeneity and Shape Change During the Compression-Type Forming Process
Authors: Hwang Joong-Ki 
Published: October 2022

Abstract
The influence of elongation on the strain inhomogeneity and shape change in twinning-induced plasticity steel rod is systematically investigated to understand the macroscopic shear band (MSB) formation mechanism and to decrease the strain inhomogeneity during the compression-type forming processes. Specimens fabricated by rod flat rolling with elongation (3D rod) and by plane compression without elongation (2D rod) are compared using both finite element analysis and experiment. Despite the similar final product shape, the 2D rod presents a lower effective strain at the surface region than the 3D rod, leading to a high strain inhomogeneity. The higher effective strain at the surface region of the 3D rod is mainly attributed to the elongation of the 3D rod during the rolling. In contrast, the 2D rod exhibits strong dead metal zones owing to the lack of elongation of the specimen. Therefore, the formation of MSBs or strain inhomogeneity of a specimen can be reduced by increasing the elongation of the specimens during the forming process. Both the contact width and lateral spread of the 3D rod are lower than those of the 2D rod because of the elongation of the 3D rod originating from the slip effect at the rod–roll interface during the rolling process. The small frictional effect at the rod and roll interface increased the elongation of the rod, leading to a decrease in the strain inhomogeneity and lateral spreading in the 3D rod.
A Hybrid Semantic Networks Construction Framework for Engineering Design
Authors: Cheligeer Cheligeer , Yang Jiami , Bayatpour Amin , Miklin Alexandra , Dufresne Stéphane , Lin Lan , Bhuiyan Nadia , Zeng Yong 
Published: October 2022

Abstract
This paper proposes a novel framework for building semantic networks from a seed design statement using Recursive Object Modeling (ROM), Word2Vec language modeling, and vector semantic-based method. Semantic Scholar API was used to retrieve abstracts of scientific papers to build ROM-based Semantic Networks to address the design problem implied in the seed design statement, following Environment Analysis from Environment-Based Design (EBD) methodology. The proposed framework was applied to construct the semantic network for a project to design aircraft braking systems, which demonstrates the framework's efficiency. The presented research makes two major contributions: a ROM-based phrase extractor and a domain-specific language model, which is trained on the automatically collected literature abstracts. Using a manually created and assessed truth set containing 100 pairs of abstract-key phrases, the phrase extractor was evaluated by benchmarking it with two existing off-the-shelf key phrase extraction algorithms: TextRank and Rake. The ROM-based phrase extractor extracted most key phrases from target domains and showed higher precision, recall, and F-1 scores than other methods. Meanwhile, the trained project-specific language model was evaluated using the NASA thesaurus. We randomly sampled 457 pairs of connected domain-specific terms related to aircraft braking and landing knowledge. Our Skip-gram model was compared with Google's pre-trained word2vec model and a baseline word2vec model. The results demonstrated that our language model could detect the most pairs of concepts from the NASA thesaurus. The generated semantic network can be applied to design information retrieval, computer-aided design idea generation, cross-domain communication support system, and designer training tool.
Stress Shifting Effect of Hydrogen Mixed Natural Gas Pipe Under Seismic Wave
Authors: Yang H. H. , Zhang J. , Chen Y. 
Published: October 2022

Abstract
Hydrogen energy is a kind of clean secondary energy sources. Mixed hydrogen natural gas transportation technology is a new scheme of hydrogen transportation. Using natural gas pipe to transport hydrogen is expected to further promote its application. In order to study the mechanical properties of buried steel pipe under seismic waves, a numerical model is established. The time history and stress distribution of pipe section under seismic wave are analyzed. Effects of seismic intensity, surrounding soil, buried depth and seismic wave type on pipe's mechanical properties are discussed. The results show that the pipe section stress fluctuates under seismic wave, and the stress shifting effect occurs. The maximum stress is located in the directions of 45 deg, 135 deg, 225 deg, and 315 deg. Stress increases with the increasing of seismic intensity, and the stress distribution of pipe section is also changed. Stress responses of the pipe in different soil are different, and the stress distribution of pipe section at the maximum stress time is similar. The deeper the buried depth is, the greater the pipe stress is. Pipe stress is related to the maximum acceleration of the seismic wave and spectrum characteristics. Those results can provide a basis for the design and safety evaluation of mixed hydrogen natural gas pipes.
Numerical Investigation of Temperatures in Ultra-Large Off-the-Road Tires Under Operating Conditions at Mine Sites
Authors: Ma Shaosen , Wu Linping , Liu Wei Victor 
Published: October 2022

Abstract
The objective of this study is to conduct a numerical investigation to examine the temperatures in off-the-road (OTR) tires under operating conditions at mine sites. To achieve this, a new mathematical equation was developed based on a modified Mooney–Rivlin (MR) strain energy function, the pseudo-elasticity theory, and the inverse analysis method. This equation was used to determine the internal heat generation rates of tire rubbers. With heat generation rates, the governing equation of heat conduction and the mathematical expression of boundary conditions were further generated to describe the heat transfer in tire rubbers. Based on these equations, a novel finite element (FE) OTR tire thermal (OTRTire-T) model was developed. This OTRTire-T model was used to numerically investigate temperatures in OTR tires at vertical loads from 0.34 to 1.04 MN, hauling speeds from 5 to 30 km/h, and ambient temperatures from −30 to 40 °C. The results showed that a large vertical load (e.g., 1.04 MN) increased the tire rubber temperatures considerably. Tire rubber temperature also increased with an increase in hauling speeds, and the increase became more significant at larger vertical loads (e.g., 1.04 MN). The OTRTire-T model identified an inverse proportional relationship between the rubber temperature increments and the ambient temperatures from −30 to 40 °C. Nonetheless, the rubber temperature in the OTR tire increased relatively rapidly with an increase in ambient temperatures.