bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of gamma radiation on optical properties of PVA/PEG/EY blend, and radiochromism.
Authors: Alibwaini Yamen , Ajlouni Abdul-Wali , Sharshar T. , Ashour Ahmed , Elsehly Magda , Arrasheed Enas , Hemeda Osama , ElShater Reda , Henaish Ahmed 
Published: September 2022

Abstract
PVA/PEG/EY samples were irradiated using of 50 KGy, gamma radiation dose. To investigate the effects of irradiation on the optical properties of the blend, UV-vis spectroscopy is used to study 6 samples of the blend, with different PEG content, 0, 1, 3, 5, 10, 15 percent, before and after irradiation. Radiation effects manifest itself as many changes in the following parameters: The absorption for all sample decreases after irradiation, the direct and indirect energy gap value increases after irradiation, the values of the extinction coefficient decrease after irradiation. The values of the extinction coefficient, k, of the nonirradiated samples are decreased or increased depending on the PEG content, while it increased for all irradiated samples despite of the PEG content. The refractive index, n, increases with increasing PEG concentration for irradiated and nonirradiated samples. The main changes occurred in the optical parameters after irradiation are: an increase in the values of the dispersion energy parameter, Ed, an increase in the single oscillator energy Eo, an immense decrease in the average oscillator strength, So, a large increase in the ratio of the effective number of carrier concentration to the effective mass of the electron (e2 /πc2). The values of the real and imaginary parts of the optical permittivity of irradiated samples are less than nonirradiated samples. The optical conductivity, σopt, increase for all irradiated samples. The values of O.D, are changing in four specific regions. The decrease and increase in O.D values depend on the variation in absorbance values which depend on PEG concentrations, and the role of irradiation in changing the absorbance of the blend.
NOTCH-pathway inactivation reprograms oral-stem-like cancer cells to JAK-STAT dependent state and provides the opportunity of synthetic lethality
Authors: Ghosh Subhashis , Mitra Paromita , Saha Uday , Ghosh Arnab , Biswas Nidhan Kumar , Roy Shantanu Saha , Acharya Moulinath , Singh Sandeep 
Published: September 2022

AbstractBackground:Stem cell-like properties in cancer cells are found to be responsible for its aggressive behaviour. However, this has not been studied with respect to the bimodal NOTCH-pathway-activity status, found in oral cancer.Methods:Oral-SLCCs were enriched in 3D-spheroids. Constitutively-active and inactive status of NOTCH-pathway was achieved by genetic or pharmacological approaches. RNA sequencing and real-time PCR was performed for gene expression studies.in vitrocytotoxicity assessments were performed by AlamarBlue assay andin vivoeffects were studied by xenograft growth in zebrafish embryo. Thettests were performed to estimate statistical significance of the study.Results:Here, we have demonstrated the stochastic plasticity on NOTCH-activity axis; maintaining both NOTCH-active and inactive states of oral stem-like cancer cells (Oral-SLCCs). While Oral-SLCCs with inactive NOTCH-pathway status showed higher proliferation and aggressive tumor growth, the Cisplatin refraction was associated with active-status of NOTCH-pathway; suggesting the crucial role of plasticity on NOTCH-axis. The differentially expressed genes between NOTCH-pathway active and inactive clones clearly suggested the upregulation of JAK-STAT signaling in subset of Oral-SLCCs with lower NOTCH-pathway activity status. Confirming the function; the 3D-spheroids generated by oral-SLCCs with lower NOTCH-activity-status displayed significantly higher sensitivity to JAK-selective drugs, Ruxolitinib or Tofacitinib and siRNA mediated downregulation of tested partners STAT 3 and 4. Therefore, we adopted the strategy of synthetic lethality, where Oral-SLCCs were reprogrammed to maintain the inactive status of NOTCH-pathway by exposure to γ-secretase inhibitors, LY411575 or RO4929097 followed by targeting with JAK-inhibitors, Ruxolitinib or Tofacitinib. This resulted in a very significant inhibition in viability of 3D-spheroids as well as xenograft formation in Zebrafish embryos; whereas inhibition of either of these pathway alone were largely ineffective.Conclusion:We have demonstrated the stochastic cellular plasticity on NOTCH-activity axis. Study revealed for the first time that NOTCH-HES and JAK-STAT pathways may act as synthetic lethal pair, and as novel targets against diverse states of stemness in oral cancer. Therefore, we have provided the rational for sequential combination of NOTCH and JAK inhibitors as possible therapeutic strategy against aggressive oral cancer.
Pathological complete response to nivolumab, S1, oxaliplatin, and radiation in a patient with gastric cancer: A case report
Authors: Toyota Kazuhiro , Hashimoto Yasushi , Sakashita Yoshihiro , Yokoyama Yujiro , Murakami Yoshiaki , Takahashi Shinya , Miyamoto Katsunari 
Published: September 2022

Abstract
BACKGROUND
The addition of nivolumab to chemotherapy has proven to be superior as a first-line treatment for unresectable advanced or recurrent gastric cancer, and is currently considered the most effective treatment. The evidence for preoperative therapy is still insufficient. Here, we report the case of a patient with gastric cancer with hepatic invasion who underwent radical surgery after preoperative treatment with nivolumab plus S1 and oxaliplatin (SOX) in combination with radiation, and achieved a pathological complete response.
CASE SUMMARY
A 73-year-old man was diagnosed with clinical stage IVA (T4bN2M0) gastric cancer and generalized edema due to hypoproteinemia, anemia, and pneumonia. The patient was considered intolerant to gastrectomy with hepatectomy. After five courses of nivolumab plus SOX and radiation therapy, the tumor shrank, and his general condition improved. Distal gastrectomy with D2 lymph node dissection and combined resection of the site of liver invasion were performed. A pathological examination of the resected stomach, liver, and lymph nodes revealed no residual cancer cells.
CONCLUSION
This is the first report of a pathological complete response to pre-surgical nivolumab plus SOX and radiation in gastric cancer. This therapy is expected to become the first choice for preoperative treatment of gastric cancer in the future.
Optimization of process parameters for scanning human face using hand-held scanner
Authors: Kaushik Ashish , Punia Upender , Garg Ramesh Kumar , Yadav Mohit , Vashistha Rajat , Rathee Mannu , Sahdev Ravinder Kumar , Chhabra Deepak 
Published: September 2022

Abstract

Three-dimensional surface scanning of several anatomical areas or human body has gained popularity in current decades due to pre-surgical planning and improved workflow of patient diagnosis and treatment Living surfaces, such as the human face, have various degrees of surface complexity to account for, as well as a range of process parameters to consider. In the proposed work, the face of a person was scanned in various combinations of input parameters using a handheld laser scanner, SENSE 3D (3D system, Rock Hill, SC/USA). Scanner to surface distance, angular orientation, and illumination intensity are considered significant input parameters while using laser scanners for 3D facial data. A number of twenty experimental runs and input parameter combination were suggested by face centered central composite design. The human face has been scanned on these twenty runs to retrieve 3D CAD model and FID score of each model has been completed to investigate the quality/accuracy of the captured data. A model has been trained among input and output using a neural network and further, it is optimized using a genetic algorithm to maximize accuracy The minimum, FID score achieved 270.24, obtained with a scanning distance of 22 inches, the angular orientation of 67.5 degrees, and ambient lightning condition of 16 watt/meter square in twenty experimental runs. The accuracy is maximized by minimizing the FID score utilizing a heuristic GA-ANN technique having 28 inches as scanning distance, 48.041 degrees as angular orientation, and 18 watt/meter square as the ambient lighting condition.
Chemotherapeutic potential of AgNP orchestrated Semecarpus anacardium nut extracts against Ovarian cancer cell line, PA-1.
Authors: Lavudi Kousalya , Kokkanti Rekha Rani , S Harika G V , Patnaik Srinivas , Penchalaneni Josthna 
Published: September 2022

Abstract
Several plants have been studied to find their efficacy and anti-cancer activity in various cancers by synthesizing organic metal nanoparticles. However, usage of Semecarpus anacardium (SA) and production of green synthesized nanoparticles have not been exposed. In our study, we have focused on synthesizing silver nanoparticles using the nut extracts from SA. Characterization studies including UV-Visible spectrophotometry have confirmed the silver nanoparticle formation at 412 nm using 0.1 mM and 427 nm using 0.2 mM AgNPs. Particle size was recorded at 1.4 nm confirming their effectivity and zeta potential studies confirmed the respective charge of -38.6 mV of the particle. Anti-microbial activity was shown against gram negative bacteria. MTT assay studies confirmed the anti-cancer activity against ovarian cancer cell line, PA-1. These results depict the excellent cytotoxic effect on the PA-1 ovarian cancer cell line, with an IC50 value of 250 µg/ml. Flow cytometry studies confirmed that SA methanolic nut extracts inhibited cell cycle at G0/G1 phase and induced apoptosis. Taken together, we are confirming that SA methanolic extracts have anti-cancer properties against ovarian cancer cell line, PA-1.
Reading Scene Text with Aggregated Temporal Convolutional Encoder
Authors: Ma Tianlong , Du Xiangcheng , Wu Xingjiao , Jin Cheng 
Published: September 2022

Abstract
Reading scene text in the natural image is of fundamental importance in many real-world problems. Recent scene text recognition methods employ the encoder-decoder framework, which constructs the encoder by obtaining the visual representations based on the last layer of the backbone network and then feeding them into a sequence model. In this paper, we propose a novel encoder structure that performs the feature extractor and the sequence modeling within a unified framework. The introduced Aggregated Temporal Convolutional Encoder (ATCE) first incorporates the temporal convolutional layers to consider the long-term temporal relationship in the encoder stage. The aggregation of these temporal convolution modules is designed to utilize visual features from different levels, by augmenting the standard architecture with deeper aggregation to better fuse information across modules. We also study the impact of different attention modules in convolutional blocks for learning accurate text representations. We conduct comparisons on several scene text recognition benchmarks; the experiments demonstrate the complementary ability with different decoder variants and the effectiveness of our proposed approach.
Ferrocene-based polyesters with azobenzene linker: Synthesis and biological evaluation
Authors: Rahman Rahima , Gul Asghari , Lensen Marga. C. , Akhter Zareen 
Published: September 2022

Abstract
Ferrocene-based terpolyesters having azobenzene linker in the
chains were synthesized in good yields (82-91%) by solution
polycondensation of aromatic (1, 2, 3) and aliphatic diols (2, 4,
6) with 1.1¢ ferrocene dicarboxylic acid chloride (F) with
molecular weight in the range 96000-99000 g/mol. These synthesized
ter-polyesters were found to have good solubility in chlorinated
and polar aprotic solvents. The structural characterization of the
material was carried out by different techniques like elemental
analysis, Fourier transform infrared spectroscopy (FTIR), proton
nuclear magnetic resonance (1H-NMR), and UV-visible spectroscopy.
Cell cyto-compatibility of these polymers was tested against L-929
mouse cells using a live dead assay. Anti-cancer and antibacterial
activity of the PABEs was determined against E. coli and Hep-G2 by
cell number measurement (in triplicate by counting of healthy cell
nuclei with array scan after Hoechst 33342 stain). The results
revealed good antibacterial and anticancer activities (up to 41%
bacterial inhibition and up to 70% cancer cell growth inhibition
respectively).
The Hidden Lives of Families Facing Pediatric Cancer Through a Narrative Medicine Perspective
Authors: Holstrom-Mercader Maria S. , Lorenz F. Jeffrey , Darok Matthew C. , Ho Lisa , Freiberg Andrew S. , Dellasega Cheryl 
Published: September 2022

Abstract
With specific tasks to fulfill, physicians often interact superficially with patients and their families to provide health care in the form of diagnosis and treatment. They miss so-called hallway conversations that may contain important information about the patient and family’s mental and social well-being. How, then, are they able to comprehensively address the more cryptic effects of cancer therapy that are not directly related to their patient’s physical health? In this study, a team of pre-clinical medical students analyzed 120 narrative journals written over an 11-year period by 119 3rd and 4th -year medical students who shadowed patients and their families in the pediatric hematology/oncology department of an academic medical center. These students did not fulfill clinical duties but learned about the cancer experience by shadowing pediatric patients and their families. The goal of this narrative study was to analyze these journals for content that revealed experiences of patients and their families that are not necessarily recognized by the healthcare team. These students were often involved in the most intimate moments of the cancer journey: receiving bad news, witnessing a child’s pain, and dealing with the death of a loved one. These experiences allowed the students to describe reactions that are often unobserved using narrative writing. With this information, multi-faceted treatment plans that go beyond the physical health of the child can be developed that incorporate the more obscure psychosocial, mental, and emotional health needs. This narrative style may also serve as a novel strategy for future clinical rotations.
Deep democratisation of technology can support a pluriverse of approaches for sustainability
Authors: Haklay Mordechai (Muki) , Moustard Fabien , Lewis Jerome , Gibbs Hannah M. B. , Moreu Marcos , Vittoria Alice , Attoh Emmanuel M. N. A. N. , Hoyte Simon , Chiaravalloti Rafael Rafael , Laws Megan , Tarrant Megan , Saiefert Thiago , Fryer-Moreira Raffaella 
Published: September 2022

AbstractThe overwhelming global dominance of modern industrialism stifles the visibility of alternative ways of being in the present and of what solutions to large-scale challenges may be appropriate. This paper describes how novel high-tech digital tools can be co-designed with people with different worldviews or ‘ontologies’ to better represent their normally marginalised understandings, and so begin to generate a pluriverse of localised pathways to address the future. To do so, such digital tools are not considered as technological artefacts but as socio-technical processes designed around local worldviews to encode alternative understandings of local issues and local knowledge into data collection and visualisation processes. We describe how the Sapelli digital mapping tool is implemented through participatory co-design approaches with Indigenous people, farmers, and agro-pastoralists. Representing different cultures and local knowledge systems in a digital third space has revealed a plurality of approaches to addressing environmental change that differ substantially from those conventionally envisaged.
HAUS1 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma
Authors: Liu Wenfeng , Lu Qiaoling , Niu Hao 
Published: September 2022

Abstract
Background: Hepatocellular carcinoma (HCC) has become fatal and aggressive cancer worldwide. It was found that HAUS1 protein was involved in the completeness of the wire, the spindle component and the completion of the cytoplastic split process during the rotor splitting process. However, HAUS1 potential value, including its level in HCC, relationship with clinical outcome and immune infiltration are not wellknown.
Methods:TIMER2.0 database was used for analyzing Pan-cancer, and differences in the expression of HAUS1 were found. The prognostic significance of HAUS1 in HCC was assessed with the Kaplan-Meier Plotter. We also investigated clinical indicators differences between the low and high HAUS1 groups. Signaling pathways associated with HAUS1 were explored by gene set enrichment analysis (GSEA). And immune cell infiltration was assessed using the CIBERSORT algorithm and the ESTIMATE method. Proliferative changes in HCC cells after knockdown of HAUS1 were assessed with CCK8 array and colony formation assays.
Results: The results showed that HAUS1 was significantly high expressed in most malignant tumors, and there were significant correlations between HAUS1 and overall survival and progression free survival in HCC. The signal pathways related to E2F targets, DNA repair, myc targets, mitotic spindle and G2M checkpoint were enriched in high HAUS1 group. What’s more, HAUS1 was shown to be related with immune cell infiltration level in the HCC. However, the proliferation of HCC cells was significantly decreased after transfection with HAUS1 specific small interfering RNA.
Conclusion: HAUS1 is a positive regulator of HCC progression and contributes to tumor cell proliferation. In addition, HAUS1 expression is related to the level of immune cells infiltration in HCC. Therefore, HAUS1 may be a novel prognostic marker and therapeutic target for HCC patients.
Quality of life in intermittent exotropia for Korean children and their patrents
Authors: Oh Jin Seon , Jung Jae Ho , Shin Hyun Jin 
Published: September 2022

Abstract
Background
Patients with strabismus are more likely to have mental health problems, including high rates of depressive symptoms and social phobia. Intermittent exotropia (IXT) typically occurs in early childhood and is more common in Asian populations. We aim to assess the health-related quality of life (HRQOL) concerns in children with intermittent exotropia (IXT) using the Intermittent Exotropia Questionaire (IXTQ), and their associations with the clinical severity of IXT and the parents’ HRQOL concerns.
Methods
One hundred twenty-two children with IXT (aged 5–17 years) and one parent for each child completed the child and parent IXTQ, respectively. The final IXTQ score is calculated using the mean score for all items, and ranges from 0 (worst HRQOL) to 100 (best HRQOL). The correlations of child IXTQ scores with their deviation angle and stereoacuity were measured, as were those with their parent’s IXTQ scores.
Results
The greatest HRQOL concern for each child with IXT and their parent was “Worry about eyes.” Lower child IXTQ scores were associated with a larger deviation angle. “Shutting one eye when it is sunny” and “Waiting for their eyes to clear up” were more common in children with a larger deviation angle. The parent IXTQ scores were lower than the child ones and showed a positive correlation with child IXTQ scores. Lower parent IXTQ scores were associated with poor distance stereoacuity.
Conclusion
The HRQOL of IXT children was closely related to that of their parents. A larger deviation angle and worse distance stereoacuity function may predict more-negative impacts on children and their parents, respectively.
Structural and functional characterization of protein isolate from Lepidium sativum with antioxidant and antidiabetic activities
Authors: Kadam Deepak , Kadam Aayushi , Tungare Kanchanlata , Arte Priyamvada , Lele S. S. 
Published: September 2022

Abstract
The extraction of protein from Lepidium sativum (LS) seed cake was optimized to obtain a yield of 18.32% at an alkali concentration of 0.16 M, buffer to sample ratio of 1/25 (w/v), a period of extraction of 15 min at 25°C. The physicochemical attributes, amino acid composition as well as functional properties of Lepidium sativum protein isolate (LSPI) were evaluated. Determining amino acid composition indicated that the isolated protein is a decent source of dietary essential amino acids with 41.36% being essential amino acids. The secondary structure of LSPI was mainly constituted by β-structures. Further, the protein isolate exhibited an excellent solubility profile at basic pH. Experimental data obtained from physicochemical analysis implies that the LSPI had excellent water holding and oil absorption capacity, emulsification property, foaming capacity and stability. LSPI exhibited significant antioxidant, anti-diabetic and protein digestibility activities making them an excellent candidate for nutritional food development.
Tectonic environment and provenance analysis of the Late Triassic Gande Formation in northern Bayan Har: Constraints from the Geochemistry of clastic rocks and U-Pb zircon dating
Authors: tian guanghao 
Published: September 2022

Abstract
Gande formation is one of the Mesozoic sedimentary strata in Bayankala mountain area,On the basis of previous studies,Based on the petrology of clastic rocks of Gande formation,Rock geochemistry, U-Pb zircon dating,The sedimentary age, tectonic environment and provenance of the Gande formation are discussed.The tectonic setting of the source area of Gande formation is active continental margin and continental island arc.The Kunlun West Qinling continental arc is one of the main provenances of the Gande formation,The clastic materials come from collision orogenic belt and subduction subduction suture belt.The U-Pb zircon ages of detrital zircons from the Gande formation are mainly concentrated at 266Ma and 285Ma in the late Paleozoic,458Ma in the early Paleozoic,1600Ma,1800Ma and 2500Ma in the Proterozoic.Hercynian Indosinian and Caledonian magmatism is the main source of detrital zircons in this area.
Study of the use of dredged sand as an alternative to beach sand and coastal dunes for coastal preservation
Authors: Noufid Abdelhamid , Hidar Nadia , Feddaoui M’barek 
Published: September 2022

Abstract
The need for construction sand needs to increase due to the increase in population. The use of dunes and coastal sand disfigures shorelines and the consequences are alarming. It is therefore necessary to consider replacing these resources with other more ecological ones. Hence the purpose of this article. In this paper, we study the correct formulation of concrete using dredged sand, respecting the standards, and analyze the impact of this new material on the physical and mechanical characteristics of concrete. This article aims to evaluate the effects of 9 formulations, used as substitutes for ordinary sand, on the physico-chemical and mechanical properties. The experimental results have shown that the dredged sand affects the properties of the concrete, but respecting the standards in force. This mode of incorporation also has an environmental advantage over the substitution of concrete for dredged sand, as it reduces the disfigurement of the coasts. The paper studies dredge sands from two regions namely Azemour and Mehdia.