bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant cardiac myxoma misdiagnosed as schizophrenia: a case report
Authors: Wang Yalin , Xu Hongfei 
Published: November 2022

Abstract
Background
Myxoma is the most common cardiac tumor and usually presents in the left atrium. Patients typically present with tightness of the chest, fatigue and lassitude. There are also cases of misdiagnosis and missed diagnosis. Improvements tend to occur with early diagnosis, and with the help of high-resolution imaging technology, such as transthoracic echocardiography (TTE), transesophageal echocardiography (TEE) and computed tomography (CT).
Case presentation:
A 59-year-old Chinese woman complained of tightness in her chest, fatigue and lassitude for eight years. She had been misdiagnosed with schizophrenia by the local rural hospital. CT confirmed a giant mass in the left atrium, and TTE revealed left atrial enlargement with an occupying lesion. Tumor resection surgery was performed under cardiopulmonary bypass. The giant tumor was partially detached during the operation, and the thrombus was removed successfully. After the operation, the mental health department of our hospital believed that the diagnosis of schizophrenia was a misdiagnosis. The patient recovered uneventfully and appeared rejuvenated after the operation. A three-year follow-up showed no adverse events since the operation.
Conclusions
A rare case of cardiac myxoma misdiagnosed as schizophrenia is presented here. When patients complain of chest tightness, we cannot forget the importance of cardiac physical examination and echocardiography. Any diagnosis of schizophrenia requires exclusion of organic disease. Careful and complete resection of the cardiac myxoma is necessary, as it may cause thromboembolism.
Effect of prolonged (150 days) post-fermentative maceration in steel tanks and oak barrels on Cabernet Sauvignon wine quality: mathematical modelization of the phenolic compounds behaviour
Authors: Bambina Paola , Pollon Matteo , Squadrito Margherita , Barone Stefano , Cinquanta Luciano , Corona Onofrio 
Published: November 2022

AbstractThe aim of this study was to evaluate the effects of the prolonged post-fermentative maceration during the winemaking of Cabernet Sauvignon grapes in oak barrels and steel tanks and apply to this purpose a mathematical modelization to better and easily understand the dynamics and phenomena related to this process. The study focused on the time series of phenolic and volatile compounds in wines during the maceration with solid parts and residual components of the alcoholic fermentation, only for anthocyanins and non-anthocyanic flavonoids two mathematical models were proposed. The results showed that the presence of solid parts during the post-fermentative maceration phase provided a higher content of polyphenols and total flavonoids in both oak barrel and steel tanks. The largest contents of polyphenols and flavonoids were observed in oak barrels trials. Among the anthocyanins in both trials we have assisted to a decreasing trend in delphinidin-3 glucoside, cyanidin-3glucoside, petunidin-3-glucoside and peonidin-3-glucoside, with a more accentuated process for the first two molecules in barrique trial, also acetylated anthocyanins showed a decreasing trend more intense in barrique trial. Finally, the post fermentative maceration did not affect HCTA and flavonols concentrations in wines, but rather it affects their chemical stability through the time. Post-fermentative maceration improved the sensory characteristics in terms of intensity, complexity, and persistence at both olfactory and gustatory level, especially in oak barrel vinification.
The effect of concomitant use of proton pump inhibitors with CDK 4/6 inhibitors on survival in metastatic breast cancer
Authors: Çağlayan Dilek , Koçak Mehmet Zahid , Geredeli Çağlayan , Tatlı Ali Murat , Göksu Sema Sezgin , Eryılmaz Melek Karakurt , Araz Murat , Artaç Mehmet 
Published: November 2022

Abstract
Aim
To evaluate the difference of progression free survival between the patients using concomitant proton pump inhibitors and non-users in the patients using CDK 4/6 inhibitors with HR + and HER2 negative mBC.
Methods
We included 86 patients with HR + and HER 2 negative mBC treated with CDK 4/6 inhibitors in this study. Patients were divided into two categories according to their status of PPI use. The primary end points was progression free survival(PFS). We compared PPI users and non-users.
Results
Forty-five (52.3%) patients used a PPI concomitantly with a CDK 4/6 inhibitor, and 41 (47.7%) did not. The median duration of follow-up was 10.68 (1.94–27.56) months. Of the patients; 50 (58.1%) palbociclib and 36 (41.9%) received ribociclib. The median progression free survival (mPFS) was 10.9 months (95% CI: 7.5-14.27) in the group with concomitant PPI use with a CDK 4/6 inhibitor, whereas the median progression free survival could not be reached in the group without concomitant PPI use (p = 0.04). In addition, concomitant PPI use with palbociclib was associated with a shorter PFS, there was no significant difference between the concomitant PPI users and non-users in terms of PFS in the patients using ribociclib.
Conclusion
Palbociclib and ribociclib are weak base drugs so their bioavailability is pH-dependent. PPIs can affect their solubility and their concentration in the plasma. Therefore we must avoid concomitant use of PPIs and CDK 4/6 inhibitors. If we need to use concomitant PPI and CDK 4/6 inhibitors, we should prefer ribociclib than palbociclib.
Synthesis, characterization, and applicability of an acrylic acid-grafted sodium alginate- based Zinc oxide hydrogel nanocomposite for crystal violet dye removal
Authors: Aljeboree Aseel M. , Albdairi Hadeel K. , Alkaim Ayad F , Mahdi Ahmed B. , Salman Abbas Washeel , A Jawad Mohammed 
Published: November 2022

Abstract
In this current research work, hydrogel composite polymer of sodium alginate-g-(polyacrylicacid-co-Sodium4-vinylbenzenesulfonate)/zinic oxide hydrogel (SA-g-(PAAc-co-VBS)/ZnO has been synthesized to be an efficient adsorbent for cationic dye namely crystal violet (CV). The physicochemical properties of the synthesized compound were identified via several characterization techniques such as Fourier transform infrared (FTIR), Field emission scanning electron microscope (FE-SEM), Thermo gravimetric analysis (TGA), X-ray diffraction (XRD), and Transmission electron microscopes (TEM). The adsorption kinetics and equilibrium isotherm of (SA-g-(PAAC-co-VBS)/ZnO towards CV removal were best fitted the pseudo-first-order and Freundlich isotherm models respectively (Qe =956.56 mg/g ) at optimum condition temperatures 30 oC, Conc.= 200 mg. L-1, pH= 6.6, and weight of surface 0.04 g/100 ml. Recyclability and Desorption studies indicated the best recycling performance at 3 cycles of using (SA-g-(PAAC-co-VBS)/ZnO), with a significant efficiency >80%. Depend on the results, the synthesized SA-g-(PAAc-co-VBS)/ZnO can be applied as a promising, eco-friendly, cost-effective, and efficient adsorbent for cationic dye removal.
Construction of epithelial-mesenchymal transition related miRNAs signatures as prognostic biomarkers in gastric cancer patients
Authors: Xiao Jun , Zhang Fan , Liu Wenju , Zang Wei-Dong 
Published: November 2022

Abstract
Aim: To identify the potential post-healing EMT related miRNAs associated with lymph node metastatic gastric cancer (LNMGC).
Methods: Both RNA expression and clinical medical data were obtained from the TCGA dataset. We performed differential expression and normalization analysis of miRNAs. Cox linear regression model confirmed the differentially expressed miRNAs (DEmiRNAs) and clinical medical parameters related to overall survival (OS). The role of target genes of DEmiRNAs was determined according to the role enrichment analysis.
Results: We obtained a total of 7531 DEmRNAs and 267 DEmRNAs, of which 185 DEmRNAs were down-regulated and 82 DEmRNAs were up-regulated. We randomly divided the LMNGC cases (n=291) into a training group (n=207) and a test group (n=84). The results showed that a total of 103, 11, 13 and 83 overlapping genes were associated with hsa-mir-141-3p, hsa-mir-4664-3p, hsa-mir-125b-5p and hsa-mir-7-5p, respectively. Kaplan-Meier determined that these four miRNAs can effectively distinguish high-risk and low-risk groups, and have a good indicator role (all p<0.05).
Multivariate cox regression analysis also showed that EMT-related miRNA predictive model and lymph node metastasis were both prognostic risk factors (all p<0.05). The ROC curve showed that this feature had high accuracy (AUC>0.7, p<0.05). In addition, KEGG analysis showed that EMT-related pathways were mainly enriched in HIF-1 signaling pathway and focal adhesion.
Conclusions: Our study demonstrated that EMT-related miRNAs could serve as independent prognostic markers in pN1-3 GC patients.
Prognostic value of perioperative inflammatory immune and nutritional indicators in patients with atrial fibrillation after lung cancer surgery
Authors: Wang Rui , Shi Genya , Li Tingting , Xu Shuang , Zhang Qing , Jiang Tongtong , Xia Yunlong , Shi Tieying 
Published: November 2022

Abstract
Objective
To investigate the prognostic value of the Prognostic Nutritional Index, Neutrophil to Lymphocyte Ratio, and Platelet to Lymphocyte Ratio in patients with atrial fibrillation after lung cancer surgery, which can provide objective predictors for screening patients with poor prognosis.
Methods
From April 2020 to August 2022, 157 patients with atrial fibrillation after lung cancer resection were enrolled. The blood levels of PNI, NLR, and PLR were collected on the last day before surgery and the day of the surgery. Patients were grouped according to the median or the ROC curve's best cut-off point. The K-M survival curve was drawn to analyze the incidence of composite adverse prognostic events in different groups, and COX regression was used to analyze the influencing factors of composite adverse prognostic events.
Results
The K-M survival curves of the high NLR group on the last day before the surgery (P = 0.007), the high PLR group on the day of the surgery (P = 0.022), and the high PLR group on the last day before the surgery (P = 0.001) were significantly different. The high PLR group on the last day before the surgery (HR = 4.225, 95%CI 1.715–10.410) and history of malignant tumor (HR = 3.548, 95%CI 1.178–10.690) were independent risk factors for composite adverse prognostic events in patients with AF after lung cancer surgery.
Conclusions
Patients with a preoperative PLR > 173.55 on the last day before the surgery and a history of malignant tumor are the effective indicators for the occurrence of combined adverse prognostic events in patients with atrial fibrillation after lung cancer surgery.
A comprehensive assessment of temperature difference and natural convection on phase transition in different latent heat storage systems accompanied by porous media
Authors: Naghdi Mohammadreza Naghdi , Borji Mehdi , Gholami Raheb 
Published: November 2022

Abstract
With the constant increasing demand for energy and the challenges arising from the growing population, securing a reliable energy supply seems critical. Latent energy storage is introduced as one of the most efficient solutions to harness the renewable and waste energy and secure a constant supply. The phase change material (PCM) in this type of energy storage suffers from low responsiveness, slowing down the industrialization of latent storage. This study proposed different conventional PCM-based storage units to numerically analyze the most influential determinant in each system during the melting evolution. The working fluid temperature, natural convection and porous media at different porosities are the factors selected for comparison between four configurations. The temperature of working fluid is of similar significance to three types of units as an enhancement of 22% has been obtained by 5 degrees increase in inlet temperature, while the pipe model has benefited almost 26% improvement under the same condition. Triplex tube heat exchanger (TTHX) in all scenarios outperforms other units since the heat transfer area for this type is greater that that of its counterparts. Natural convection phenomenon is most effective in the pipe model as its absence decelerate the melting rate by 236%. Porous media integration produced, by average, 93% faster systems thanks to its extra heat transfer surface, although it suppressed the gravitational movement.
Wing-attached Hatchback Vehicle in Adverse Weather Conditions
Authors: Uddin Md Shehab , Sarker Md Rabiul Islam 
Published: November 2022

Abstract
In recent years, road accidents due to heavy rainfall have become an alarming issue that needs to be researched. In this regard, a comparative study is performed from the aerodynamic perspective to observe the flow phenomena alteration around a generic hatchback ground vehicle. The analysis deals with a 75% scaled wing-attached Ahmed body where NACA 0018 airfoil profile is chosen for the wing profile. All the possible combinations are compared initially by the RANS-based k-epsilon turbulence model at a Reynolds number 2.7×106. Later, the instantaneous flow phenomenon is analyzed with the LES formulations. The simulation results imply an 11–12% average increase in the drag coefficients for with and without wing conditions and a decrease in lift coefficients by 24% for the wing-attached state. Besides this, shifts in the critical drag and lift coefficients' slant position from 25° to 15° in the wing-attached normal state and 12.5° in the wing-attached rain state are noticed. The careful inspection of different vortex formations, merging, energy distribution associated with the eddies, and pressure coefficient variations reveal the tentative reasons for the aerodynamic penalties. Also, the instantaneous flow analysis discovers an additional recirculation region for the wing-attached condition. This study will assist in obtaining a distinct picture of the aerodynamic penalties faced by a hatchback ground vehicle under heavy rain conditions and finding the role of a rear wing in overcoming adverse weather conditions.
Analysis of subcellular localization and pathogenicity of Plum bark necrosis stem-pitting associated virus protein P6
Authors: Li Yuanyuan , Mou Jinze , Li Qingliang , Liu Huabing , Wang Deya , Yuan Xuefeng 
Published: November 2022

Abstract
Infection of plum bark necrosis stem pitting associated virus (PBNSPaV) has been reported in many prunus species in several countries, causing significant economic losses. The very small proteins encoded by plant viruses are often overlooked due to their short sequences and uncertain significance. However, numerous studies have indicated that they might play important roles in the pathogenesis of virus infection. The role of small hydrophobic protein P6, encoded by the open reading frame 2 of PBNSPaV, has not been well explored. In this study, we amplified the P6 fragment from a PBNSPaV isolate by RT-PCR using specific primers and found that it is 174 bp long and encodes a protein of approximately 6.3 kD with a transmembrane domain. Subcellular localization analysis of P6 proteins in tobacco leaves showed that P6 localizes in cytomembrane and nuclear membrane. To further clarify the pathogenicity of P6 proteins, a PVX-P6 expression vector was constructed by inserting the p6 fragment into a potato virus X (PVX)-based vector and transformed into Agrobacterium tumefaciens GV3101. Infiltration of N. benthamiana with the PVX vector-transformed A. tumefaciens led to slight mosaic symptoms at 14 days of post-inoculation. Meanwhile, infiltration with the PVX-P6 vector-transformed A. tumefaciens resulted in no significant symptoms. These results demonstrated that heterologous expression of P6 in N. benthamiana could not enhance the pathogenicity of PVX. Our study indicates that p6 may not be a potential pathogenic factor associate with the causing of symptoms, and mode of action of PBNSPaV-P6 protein remain to be further studied.
Overall evaluation of the replacement of fermented soybean to fish meal in juvenile white shrimp, Litopenaeus vannamei diet: growth, health status, and hepatopancreas histomorphology
Authors: El-Naby Asmaa S. Abd , Eid A. E , Gaafar Alkhateib Y. , Sharawy Zaki , Khattaby A. A , El-sharawy Mohamed S. , Asely Amel M. El , Asely Amel El 
Published: November 2022

Abstract
This study was conducted to determine the effect of replacing fishmeal (FM) with fermented soybean meal (FSBM) for 12 weeks on the growth performance, feed utilization, immunological parameters, antioxidant enzymes assays and lipid peroxidation, digestive enzymes, and histopathological analysis of juvenile Litopeneaus vannamei (L. vannamei). By substituting 0.0%, 20%, 30%, and 40% FSBM for fishmeal (w/w), four isonitrogenous diets were generated. A total of 300 juvenile L. vannamei(1.59 ±0.01 g) were randomly allocated to the experimental fiber tanks at a rate of fifteen shrimp per tank, with three replicates for each treatment. Growth performance and feed utilization decline considerably (P < 0.05) with increasing amounts of FM replacement with FSBM in diets. In comparison to the juveniles fed the other experimental diets, the diet containing a moderate level of FM replacement (20% FSBM) considerably enhanced growth performance and feed consumption during the feeding trial. The 20% FSBM-fed group had the highest protein content. In contrast, raising FSBM levels significantly increased lipid content (P < 0.05) compared to the control. However, there were no statistically significant differences (P> 0.05) across FSBM treatments. Hemolymph plasma total protein (TP) concentration and lysozyme activity were substantially greater (P < 0.05) in 20% FSBM compared to 40% FSBM (P < 0.05). In addition, 20% FSBM exhibits a substantial (P < 0.05) increase in the activity of antioxidant enzymes (CAT SOD, GPX, and GR). In contrast, the control and 30% FSBM groups had considerably more lipid peroxidation marker (MDA) than the 20% and 40% FSBM groups. Hepatopancreas amylase activity was considerably elevated (P < 0.05) in the control group and with 40% FSBM. In addition, Hepatopancreas and intestinal protease and lipase activity increased significantly by 20% FSBM. Considerably more B-cells were present in the 40% FSBM diet than in the control diet, however they were significantly less prevalent in the 20% and 30% FSBM of diets (P < 0.05).
Correlation study of changes in visual acuity, pupil diameter, Kappa angle, and Alpha angle after phacoemulsification surgery combined with multifocal IOL implantation
Authors: Zhenlin Lin , Pengfen Gao , Honghua Zheng 
Published: November 2022

Abstract
Purpose To study the changes and correlation of visual acuity, pupil size, kappa angle and Alpha angle after phacoemulsification combined with multifocal intraocular lens implantation by analyzing the data provided by OPD-ScanIII Optical Path Difference optical path difference analyzer. Methods From March 2020 to October 2021, 35 patients (60 eyes) with cataract who underwent phacoemulsification combined with multifocal intraocular lens implantation were analyzed retrospectively. The changes of pupil size, Alpha angle, Kappa angle and postoperative visual acuity were measured by OPD-ScanIII optical path difference analyzer before and 1 week after operation. The correlation between pupil size, Kappa angle, Alpha angle and distal and near visual acuity was analyzed 1 week and 1 month after operation. Sixteen eyes of cataract patients were followed up for more than one month to study the changes of pupil size, Alpha angle and Kappa angle one week and one month after operation. Results phacoemulsification combined with multifocal intraocular lens implantation significantly improved the visual acuity of the patients, and the pupil size and Kappa angle decreased 1 week after operation, but there was no significant difference between the indexes more than one month after operation and those before operation. There was no significant difference in Kappa angle and Alpha angle before and 1 week after operation, but there was significant correlation between distant visual acuity and Kappa angle in light and dark vision 1 week after operation. There was no correlation between distant visual acuity and Alpha angle and pupil size 1 week after operation. One week after operation, there was no correlation between near and middle visual acuity and Alpha angle, Kappa angle and pupil size 1 week after operation, and there was no significant difference between Alpha angle and Kappa angle and pupil size 1 week after operation. There was no significant difference between Alpha angle and Kappa angle 1 month after operation. Conclusion phacoemulsification combined with bifocal intraocular lens implantation can significantly improve the visual acuity of patients, reduce the size of light and dark pupil and Kappa angle under dark vision in a short time, and recover after long-term surgery. Therefore, phacoemulsification combined with bifocal intraocular lens surgery should not expand the optical related indexes of patients before operation, which may lead to postoperative adverse reactions and decrease satisfaction.
An Injectible Cpw Fed Flexible Radiator With Wireless Charging for Proactive Breast Tumour Detection
Authors: Chrysolite Samuelraj , Pushpa Anita Jones Mary 
Published: November 2022

Abstract
Detection of breast cancer at early stages is very important to eliminate the possibility of breast removal in women. The dielectric changes caused in the breast tissues due to the formation of cancerous cells can be monitored by a biocompatible implant. Therefore a novel flexible implantable antenna sensor with the dimension 5mm x 5mm x 0.25mm working at the ISM band (2.45 GHz) is proposed for proactive detection of cancer cells inside the human breast. It can be wirelessly powered up through Wireless Power Transfer (WPT) working at 1.2-1.4 GHz (mid-band). An ultra-miniature structure of the implantable antenna (12.5mm 3 ) is achieved by using closed loops and meandered strips making the implant an efficient radiator. A reflection coefficient of -17dB is achieved with a -10dB bandwidth of 330 MHz inside the abnormal breast tissue (ε r -52.7). Once the permittivity of the breast tissue increases and crosses 15, the radiator starts working and a maximum of -10dBi gain is achieved. The proposed antenna is fabricated and the simulated results are verified. It can be used for proactively detecting the cancer cells inside the human breast and treating it before it spreads to the nearby tissues. Patients with a genetic history of breast cancer can be administered the proposed implant for proactive monitoring of the development of cancerous cells.