bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left ventricular assist device-related infections and the risk of cerebrovascular accidents: a EUROMACS study
Authors: Zijderhand Casper F , Antonides Christiaan F J , Veen Kevin M , Verkaik Nelianne J , Schoenrath Felix , Gummert Jan , Nemec Petr , Merkely Béla , Musumeci Francesco , Meyns Bart , de By Theo M M H , Bogers Ad J J C , Caliskan Kadir 
Published: August 2022

Abstract

OBJECTIVES
In patients supported by a durable left ventricular assist device (LVAD), infections are a frequently reported adverse event with increased morbidity and mortality. The purpose of this study was to investigate the possible association between infections and thromboembolic events, most notable cerebrovascular accidents (CVAs), in LVAD patients.

METHODS
An analysis of the multicentre European Registry for Patients Assisted with Mechanical Circulatory Support was performed. Infections were categorized as VAD-specific infections, VAD-related infections and non-VAD-related infections. An extended Kaplan–Meier analysis for the risk of CVA with infection as a time-dependent covariate and a multivariable Cox proportional hazard model were performed.

RESULTS
For this analysis, 3282 patients with an LVAD were included with the majority of patients being male (83.1%). During follow-up, 1262 patients suffered from infection, and 457 patients had a CVA. Cox regression analysis with first infection as time-dependent covariate revealed a hazard ratio (HR) for CVA of 1.90 [95% confidence interval (CI): 1.55–2.33; P &lt; 0.001]. Multivariable analysis confirmed the association for infection and CVAs with an HR of 1.99 (95% CI: 1.62–2.45; P &lt; 0.001). With infections subcategorized, VAD-specific HR was 1.56 (95% CI: 1.18–2.08; P 0.002) and VAD-related infections [HR: 1.99 (95% CI: 1.41–2.82; P &lt; 0.001)] remained associated with CVAs, while non-VAD-related infections (P = 0.102) were not.

CONCLUSIONS
Infection during LVAD support is associated with an increased risk of developing an ischaemic or haemorrhagic CVA, particularly in the setting of VAD-related or VAD-specific infections. This suggests the need of a stringent anticoagulation management and adequate antibiotic treatment during an infection in LVAD-supported patients.
Association of Chronic Diseases and Functional Limitations with Subjective Age: The Mediating Role of Sense of Control
Authors: Prasad Anyah , Shellito Natalie , Alan Miller Edward , Burr Jeffrey A 
Published: August 2022

Abstract

Objectives
This study examined the relationships between chronic diseases, functional limitations, sense of control, and subjective age. Older adults may evaluate their subjective age by reference to their younger healthier selves and thus health and functional status are likely to be determinants of subjective age. Although sense of control is also a potential predictor of subjective age, stress-inducing factors associated with disease and functional limitations may reduce older adults’ sense of control, making them feel older.

Methods
Using the 2010 and 2014 waves of the Health and Retirement Study, structural equation modeling was performed on a sample of 6,329 respondents older than 50 years to determine whether sense of control mediated the relationship between chronic diseases, limitations in instrumental/basic activities of daily living (ADLs, IADLs), and subjective age.

Results
Chronic diseases and limitations in ADLs had a positive, direct association with subjective age (β = 0.037, p = .005; β = 0.068, p = .001, respectively). In addition, chronic diseases and limitations in ADLs and IADLs were positively, indirectly associated with subjective age via a diminished sense of control (β = 0.006, p = .000; β = 0.007, p = .003; β = 0.019, p = .000, respectively).

Discussion
As predicted by the Deterioration model, the findings showed that chronic diseases and functional impairment are associated with older adults feeling older by challenging the psychological resource of sense of control. Appropriate interventions for dealing with health challenges and preserving sense of control may help prevent the adverse downstream effects of older subjective age.
Association mapping across a multitude of traits collected in diverse environments in maize
Authors: Mural Ravi V , Sun Guangchao , Grzybowski Marcin , Tross Michael C , Jin Hongyu , Smith Christine , Newton Linsey , Andorf Carson M , Woodhouse Margaret R , Thompson Addie M , Sigmon Brandi , Schnable James C 
Published: August 2022

Abstract
Classical genetic studies have identified many cases of pleiotropy where mutations in individual genes alter many different phenotypes. Quantitative genetic studies of natural genetic variants frequently examine one or a few traits, limiting their potential to identify pleiotropic effects of natural genetic variants. Widely adopted community association panels have been employed by plant genetics communities to study the genetic basis of naturally occurring phenotypic variation in a wide range of traits. High-density genetic marker data—18M markers—from 2 partially overlapping maize association panels comprising 1,014 unique genotypes grown in field trials across at least 7 US states and scored for 162 distinct trait data sets enabled the identification of of 2,154 suggestive marker-trait associations and 697 confident associations in the maize genome using a resampling-based genome-wide association strategy. The precision of individual marker-trait associations was estimated to be 3 genes based on a reference set of genes with known phenotypes. Examples were observed of both genetic loci associated with variation in diverse traits (e.g., above-ground and below-ground traits), as well as individual loci associated with the same or similar traits across diverse environments. Many significant signals are located near genes whose functions were previously entirely unknown or estimated purely via functional data on homologs. This study demonstrates the potential of mining community association panel data using new higher-density genetic marker sets combined with resampling-based genome-wide association tests to develop testable hypotheses about gene functions, identify potential pleiotropic effects of natural genetic variants, and study genotype-by-environment interaction.
Generic Transporters for the Linear Time-Dependent Quantum Harmonic Oscillator on ℝ
Authors: Maspero A 
Published: August 2022

Abstract
In this paper we consider the linear, time-dependent quantum Harmonic Schrdinger equation ${\textrm {i}} \partial _t u= \frac {1}{2} ( - \partial _x^2 + x^2) u + V(t, x, D)u$, $x \in \mathbb {R}$, where $V(t,x,D)$ is classical pseudodifferential operator of order 0, self-adjoint, and $2\pi $ periodic in time. We give sufficient conditions on the principal symbol of $V(t,x,D)$ ensuring the existence of solutions displaying infinite time growth of Sobolev norms. These conditions are generic in the Fréchet space of symbols. This shows that generic, classical pseudodifferential, $2\pi $-periodic perturbations provoke unstable dynamics. The proof builds on the results of [36] and it is based on pseudodifferential normal form and local energy decay estimates. These last are proved exploiting Mourre’s positive commutator theory.
The proliferative activity levels of each immune cell population evaluated by mass cytometry are linked to the clinical phenotypes of systemic lupus erythematosus
Authors: Kajihara Akiko , Morita Takayoshi , Kato Yasuhiro , Konaka Hachiro , Murakami Teruaki , Yamaguchi Yuta , Koyama Shohei , Takamatsu Hyota , Nishide Masayuki , Maeda Yuichi , Watanabe Akane , Nishida Sumiyuki , Hirano Toru , Shima Yoshihito , Narazaki Masashi , Kumanogoh Atsushi 
Published: August 2022

Abstract
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, and many peripheral immune cell populations (ICPs) are thought to be altered according to the course of the disease. However, it is unclear which ICPs are associated with the clinical phenotypes of SLE. We analyzed peripheral blood mononuclear cells (PBMCs) of 28 SLE patients using mass cytometry and identified 30 ICPs. We determined the proliferative activity of ICPs by measuring the proportion of cells expressing specific markers and Ki-67 among CD45+ cells (Ki-67+ proportion). We observed an increased Ki-67+ proportion for many ICPs of SLE patients and examined the association between their Ki-67+ proportions and clinical findings. The Ki-67+ proportions of five ICPs [classical monocyte (cMo), effector memory CD8+ T cell (CD8Tem), CXCR5− naive B cell (CXCR5− nB), and CXCR5− IgD−CD27− B cell (CXCR5− DNB)] were identified as clinically important factors. The SLE Disease Activity Index (SLEDAI) was positively correlated with cMo and plasma cells (PC). The titer of anti-DNA antibodies was positively correlated with cMo, CXCR5− nB, and CXCR5− DNB. The C4 level was negatively correlated with CXCR5− DNB. The bioactivity of type I interferon was also positively correlated with these ICPs. Fever and renal involvement were associated with cMo. Rash was associated with CD8Tem and CXCR5− DNB. On the basis of the proliferative activity among five ICPs, SLE patients can be classified into five clusters showing different SLE phenotypes. Evaluation of the proliferative activity in each ICP can be linked to the clinical phenotypes of individual SLE patients and help in the treatment strategy.
Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies
Authors: van Rhee K P , de Vroom S L , van Hest R M , van der Linden P D , Tonino S H , Molendijk E , Mathôt R A A , Blijlevens N M A , Knibbe C A J , Bruggemann R J M , Geerlings S E 
Published: August 2022

AbstractBackgroundPatients with haematological malignancies frequently endure neutropenia and gastrointestinal (GI)-mucositis after high-dose chemotherapy. In these patients, ciprofloxacin is used for Gram-negative infection prophylaxis.ObjectivesWe investigate ciprofloxacin pharmacokinetics after oral administration in patients with haematological malignancies and explore the impact of GI-mucositis on oral bioavailability and clearance in order to assure adequate systemic exposure.MethodsAdult haematological patients from two Dutch University Medical Centres received 500 mg twice daily oral ciprofloxacin for Gram-negative prophylaxis. The ciprofloxacin plasma concentrations were collected at various timepoints after oral ciprofloxacin administration and at various days after completion of chemotherapy. Data obtained after oral and intravenous ciprofloxacin administration in 28 healthy volunteers without mucositis served as a control group (391 samples). For haematological patients the degree of GI-mucositis was assessed using the Daily Gut Score (DGS), plasma citrulline and albumin. Data were analysed by non-linear mixed-effects modelling.ResultsIn total, 250 blood samples were collected in 47 patients with a wide variety of haematological malignancies between 0–30 days after start of chemotherapy. Mucositis was generally mild [DGS median (IQR) 1 (1–1) and citrulline 16 μmol/L (12–23)]. The time to Cmax was slower in haematological patients compared with healthy volunteers although no association with the degree of mucositis (defined as DGS or citrulline) could be identified. Ciprofloxacin bioavailability and clearance were 60% and 33.2 L/h, respectively.ConclusionsThis study supports oral dosing of ciprofloxacin as Gram-negative infection prophylaxis in haematological patients with mild-to-moderate mucositis capable of oral intake.
i-CLIMATE: a “clinical climate informatics” action framework to reduce environmental pollution from healthcare
Authors: Sittig Dean F , Sherman Jodi D , Eckelman Matthew J , Draper Andrew , Singh Hardeep 
Published: August 2022

Abstract
Addressing environmental pollution and climate change is one of the biggest sociotechnical challenges of our time. While information technology has led to improvements in healthcare, it has also contributed to increased energy usage, destructive natural resource extraction, piles of e-waste, and increased greenhouse gases. We introduce a framework “Information technology-enabled Clinical cLimate InforMAtics acTions for the Environment” (i-CLIMATE) to illustrate how clinical informatics can help reduce healthcare’s environmental pollution and climate-related impacts using 5 actionable components: (1) create a circular economy for health IT, (2) reduce energy consumption through smarter use of health IT, (3) support more environmentally friendly decision-making by clinicians and health administrators, (4) mobilize healthcare workforce environmental stewardship through informatics, and (5) Inform policies and regulations for change. We define Clinical Climate Informatics as a field that applies data, information, and knowledge management principles to operationalize components of the i-CLIMATE Framework.
Can Distributed Intermittent Renewable Generation Reduce Future Grid Investments? Evidence from France
Authors: Astier Nicolas , Rajagopal Ram , Wolak Frank A 
Published: August 2022

Abstract
This paper estimates the relationship between investments in five distributed generation technologies and hourly net withdrawals from over 2,000 electricity distribution networks in France between 2005 and 2018. We find that investments in distributed wind and solar generation have little or no impact on the annual peak of hourly net withdrawals from the distribution grid, while investments in hydroelectric and thermal distributed generation significantly reduce it. An optimistic analysis of the impact of investments in battery storage suggests that high levels are required for distributed wind and solar to deliver similar reductions in the annual peak of hourly net withdrawals. Our results imply that public policies favoring distributed wind and solar generation over utility-scale generation cannot be rationalized by savings in future grid investments.
In patients with acute mono/oligoarthritis, a targeted ultrasound scanning protocol shows great accuracy for the diagnosis of gout and CPPD
Authors: Cipolletta Edoardo , Filippucci Emilio , Abhishek Abhishek , Di Battista Jacopo , Smerilli Gianluca , Di Carlo Marco , Silveri Ferdinando , De Angelis Rossella , Salaffi Fausto , Grassi Walter , Di Matteo Andrea 
Published: August 2022

AbstractObjectivesTo determine an US scanning protocol with the best accuracy for the diagnosis of gout and CPPD in patients with acute mono/oligo-arthritis of unknown origin.MethodsPatients with acute mono/oligo-arthritis in whom a joint aspiration at the most clinically involved joint (target joint) was requested were consecutively enrolled. US was performed in each patient before the arthrocentesis. The accuracy of different US findings and scanning protocols for the diagnosis of gout and CPPD was calculated.ResultsA total of 161 subjects were included (32 gout patients, 30 CPPD patients and 99 disease-controls). US findings had a high specificity for gout (0.92–0.96) and CPPD (0.90–0.97), while the sensitivity ranged from 0.73 to 0.85 in gout (double contour sign and tophi, respectively) and from 0.60 to 0.90 in CPPD (hyaline and fibrocartilage deposits, respectively). The US assessment of two joints bilaterally (gout: knees, MTP1 joints; CPPD: knees, wrists) plus the target joint had an excellent diagnostic sensitivity (gout: 0.91, CPPD: 0.93) and specificity (gout: 0.91, CPPD: 0.89). This targeted US scanning protocol yielded to higher diagnostic accuracy compared with the US evaluation of the target joint [gout area under the curve (AUC) 0.91 vs 0.84, P = 0.03; CPPD AUC 0.93 vs 0.84, P = 0.04] unless the target joint was the knee or the MTP1 joint in gout and the knee or the wrist in CPPD.ConclusionsA targeted US scanning protocol of two joints bilaterally plus the target joint showed an excellent accuracy (&gt;90%) for the diagnosis of crystal arthritis in patients with acute mono/oligoarthritis. A video abstract is available for this article and can be viewed at https://doi.org/10.1093/rheumatology/keac479.
Idiopathic multicentric Castleman disease and associated autoimmune and autoinflammatory conditions: practical guidance for diagnosis
Authors: González García Andrés , Fernández-Martín Julián , Robles Marhuenda Ángel 
Published: August 2022

AbstractIdiopathic multicentric Castleman disease (iMCD) is an infrequent and life-threatening disorder characterized by systemic inflammatory symptoms, generalized lymphadenopathy, polyclonal lymphocyte proliferation and organ dysfunction caused by a hyperinflammatory state. It accounts for one-third to one-half of all multicentric Castleman disease (MCD) cases. iMCD is often associated with autoimmune manifestations that may precede the iMCD diagnosis, be identified at the same time or follow it. In addition, iMCD may also coincide with a number of autoimmune diseases (such as psoriasis or myasthenia gravis) or autoinflammatory diseases (such as familial Mediterranean fever). Moreover, diverse inflammatory disorders, such as rheumatoid arthritis, systemic lupus erythematosus, adult-onset Still disease, systemic juvenile idiopathic arthritis, immunoglobulin (IgG4) related disease, or the recently described VEXAS syndrome, can present clinical features or lymphadenopathy with histopathological ‘Castleman-like’ findings compatible with those of iMCD. Given the iMCD clinical heterogeneity and the overlap with other autoimmune or autoinflammatory disorders, iMCD diagnosis can be challenging. In this review, we explore the overlap between iMCD and inflammatory diseases and provide practical guidance on iMCD diagnosis in order to avoid misdiagnosis and confusion with other autoimmune or autoinflammatory conditions.
MODEL CALIBRATION OF AN AIRBORNE GAMMA SPECTROMETER FOR SEARCHING OF RADIONUCLIDE SOURCES USING UAV
Authors: Klusoň Jaroslav , Thinová Lenka 
Published: August 2022

Abstract
A study of a small airborne gamma spectrometer usability, carried by unmanned aerial vehicle (UAV), during a search for radionuclide sources and estimating their activity was performed. Model calculations of calibration coefficients for Georadis D230A spectrometer (with two NaI (Tl) 2″ x 2″ detectors), 241Am, 57Co, 137Cs, 192Ir, 60Co and 152Eu radionuclides and set of flight altitudes from 1 up to 25 m were done. The results were compared with the results of experimental measurements for 137Cs and 60Co sources using vertical heights up to 10 m above the source on the ground. Simulated and discussed is the possible significant influence of the source construction and housing and the position/orientation of the source (due to non-isotropic emission) to estimate the activity of an unknown source. The influence of the natural background and estimation of flight line spacing requirements when planning a UAV route to ensure source localization depending on its activity are discussed.
CONFOCAL X-RAY FLUORESCENCE ANALYSIS OF SAMPLES FORMED FROM HOMOGENEOUS LAYERS: COMPARISON OF SIMULATIONS WITH EXPERIMENTAL MEASUREMENTS
Authors: Limburská Kateřina , Trojek Tomáš 
Published: August 2022

Abstract
Confocal X-ray fluorescence analysis is a non-destructive method that enables the determination of the elements depth distribution in the examined sample. Accurate determination of the elements depth distributions in various samples from measured depth profiles is very demanding, and generally, a valid procedure has not been developed as yet. The main aim of this work was to design and test a universal simplified calculation procedure, which would allow the calculation of the approximate shape of the depth profiles for a sample formed from layers of a given thickness and composition. To confirm the proposed calculation method, the standard reference material NIST 1412 was used, which is formed by a homogeneous multicomponent glass containing oxides of several measurable elements. This research compares the results of the measured and calculated depth profiles in the glass reference material, where the resulting depth curves correspond almost perfectly.
LONG-TERM AFTERGLOW OF SOLID SCINTILLATORS
Authors: Viererbl Ladislav , Kolros Antonín , Vratislavská Hana Assmann 
Published: August 2022

Abstract
Most of scintillators used for radiation detection exhibit afterglow, which is emission of light with longer decay times than that of main light pulse. High signal from afterglow has usually negative influence on detection parameters, e.g. for energy resolution in spectrometry measurements. The paper deals with long-term afterglow of some types of scintillators, which is more significant in the case of integral measurement when current in the photodetector is measured. The range of studied decay times was in the order of tens of seconds to days. Seven types of scintillators were measured: BGO, CaF2(Eu), CdWO4, CsI(Tl), LiI(Eu), NaI(Tl) and plastic scintillator. Excitation of scintillators was made using a UV lamp. After UV irradiation, a scintillator was inserted to scintillation detection unit and the anode current of photomultiplier tube was measured with a picoammeter. As results, CaF2(Eu) and plastic scintillator have relatively low long-term afterglow signal compared with other measured scintillators.
MEASUREMENT OF PROMPT GAMMAS OF INELASTIC SCATTERING IN D2O SPHERE USING AMBE SOURCE
Authors: Czakoj Tomáš , Košťál Michal , Novák Evžen , Losa Evžen , Šimon Jan , Schulc Martin , Matěj Zdeněk 
Published: August 2022

Abstract
The inelastic neutron scattering is often followed by the emission of gamma photon. As the prompt gammas have a discrete level character they can be used for the identification of nuclides. Because of this fact, a good knowledge of photon production from inelastic scattering is important. Described research deals with the measurement of gamma originated from inelastic scattering of neutrons on 16O. The 241Am–Be was used as a neutron source because of its high average neutron energy. The oxygen in form of heavy water was used for maximization of neutron flux on oxygen and minimization of background gammas’ production, namely 2223 keV gammas accompanying capture on hydrogen 1H. The gamma spectrum was measured by HPGe and the stilbene detector. The HPGe measured quantities are comparted with calculation and discrepancies between measured and calculated gamma fluxes are reported. Stilbene measurement shows indistinguishability of gamma peaks above 6 MeV.
MEASUREMENT OF THE REGENER–PFOTZER MAXIMUM USING DIFFERENT TYPES OF IONISING RADIATION DETECTORS AND A NEW TELEMETRY SYSTEM TF-ATMON
Authors: Kákona Jakub , Lužová Martina , Kákona Martin , Sommer Marek , Povišer Martin , Ploc Ondřej , Dvořák Roman , Ambrožová Iva 
Published: August 2022

Abstract
Stratospheric balloons are a useful tool for the investigation of cosmic radiation at high altitudes and the tests of new detectors of cosmic radiation. Due to necessary data processing, the balloon gondola needs to carry, together with radiation detectors, additional supplementary sensors measuring humidity, temperature, location and orientation, altitude, atmospheric pressure, acceleration, etc. A newly developed universal system TF-ATMON, based on using already existing tools of the PX4 open-source project, enables apart from data recording and monitoring, also the possibility to trace the balloon gondola after the flight. The application was demonstrated on stratospheric balloon flight FIK-6. This flight was unique because three different types of radiation detectors were used at one flight. It enabled us to compare the altitude of the Regener–Pfotzer maximum measured with different types of sensors sensitive to a different type of secondary cosmic radiation generated in the atmosphere.