bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study on a Novel Fibula Malleolus Cap to Increase the Accuracy of Oncologic Jaw Reconstruction
Authors: Pu Jingya Jane , Choi Wing Shan , Yeung Wai Kan , Yang Wei-Fa , Zhu Wang-Yong , Su Yu-Xiong 
Published: January 2022

ObjectivesAlthough computer-assisted surgery using fibula flap has been widely applied for oncologic jaw reconstruction in recent years, the inaccurate positioning of the fibula harvest guide brings sliding and rotational errors, which leads to compromised accuracy in simultaneous implant placement and dental rehabilitation. This study aimed to develop a novel three-dimensional (3D)-printed patient-specific fibula malleolus cap to increase oncologic reconstruction accuracy.MethodsIn this prospective comparative study with a recent historical control cohort, patients in need of oncologic jaw reconstruction with fibula free flaps were recruited. In the study group, the fibula was harvested with the guide of the malleolus cap, whereas in the control group, without the malleolus cap. Deviations of location and angulation of distal fibula osteotomies, jaw reconstruction segments, and simultaneous dental implants were compared.ResultsTwenty patients were recruited, with 10 in each arm. The application of the malleolus cap significantly reduced the deviations in locations and angles of distal fibula osteotomies, from 9.5 to 4.1 mm and 25.3° to 8.7°. For the simultaneous dental implants placed in the fibula flaps, there was a significant increase in the accuracy of implant platform locations (the average deviation from 3.2 to 1.3 mm), apex locations (from 3.8 to 1.5 mm), and angles (from 11.3° to 4.6°). No significant difference was detected in the accuracy of fibula reconstruction segments.ConclusionsWe developed a novel fibula malleolus cap to overcome the sliding and rotational errors during fibula flap harvesting for oncologic jaw reconstruction, with increased accuracy in simultaneous dental implants. This is a step forward to achieve a satisfactory functional outcome of jaw reconstruction with dental rehabilitation.
Pathogenic Variant Profile of Hereditary Cancer Syndromes in a Vietnamese Cohort
Authors: Tran Van Thuan , Nguyen Sao Trung , Pham Xuan Dung , Phan Thanh Hai , Nguyen Van Chu , Nguyen Huu Thinh , Nguyen Huu Phuc , Doan Phuong Thao Thi , Le Tuan Anh , Nguyen Bao Toan , Jasmine Thanh Xuan , Nguyen Duy Sinh , Nguyen Hong-Dang Luu , Nguyen Ngoc Mai , Do Duy Xuan , Tran Vu Uyen , Nguyen Hue Hanh Thi , Le Minh Phong , Nguyen Yen Nhi , Do Thanh Thuy Thi , Truong Dinh Kiet , Tang Hung Sang , Phan Minh-Duy , Nguyen Hoai-Nghia , Giang Hoa , Tu Lan N. 
Published: January 2022

BackgroundHereditary cancer syndromes (HCS) are responsible for 5-10% of cancer cases. Genetic testing to identify pathogenic variants associated with cancer predisposition has not been routinely available in Vietnam. Consequently, the prevalence and genetic landscape of HCS remain unknown.Methods1165 Vietnamese individuals enrolled in genetic testing at our laboratory in 2020. We performed analysis of germline mutations in 17 high- and moderate- penetrance genes associated with HCS by next generation sequencing.ResultsA total of 41 pathogenic variants in 11 genes were detected in 3.2% individuals. The carrier frequency was 4.2% in people with family or personal history of cancer and 2.6% in those without history. The percentage of mutation carriers for hereditary colorectal cancer syndromes was 1.3% and for hereditary breast and ovarian cancer syndrome was 1.6%. BRCA1 and BRCA2 mutations were the most prevalent with the positive rate of 1.3% in the general cohort and 5.1% in breast or ovarian cancer patients. Most of BRCA1 mutations located at the BRCA C-terminus domains and the top recurrent mutation was NM_007294.3:c.5251C&gt;T (p.Arg1751Ter). One novel variant NM_000038.6(APC):c.6665C&gt;A (p.Pro2222His) was found in a breast cancer patient with a strong family history of cancer. A case study of hereditary cancer syndrome was illustrated to highlight the importance of genetic testing.ConclusionThis is the first largest analysis of carrier frequency and mutation spectrum of HCS in Vietnam. The findings demonstrate the clinical significance of multigene panel testing to identify carriers and their at-risk relatives for better cancer surveillance and management strategies.
Correlation Analyses of Clinical Manifestations and Variant Effects in KCNB1-Related Neurodevelopmental Disorder
Authors: Xiong Juan , Liu Zhonghua , Chen Shimeng , Kessi Miriam , Chen Baiyu , Duan Haolin , Deng Xiaolu , Yang Lifen , Peng Jing , Yin Fei 
Published: January 2022

Objective:Vitro functional analyses of KCNB1 variants have been done to disclose possible pathogenic mechanisms in KCNB1-related neurodevelopmental disorder. “Complete or partial loss of function (LoF),” “dominant-negative (DN) effect” are applied to describe KCNB1 variant's molecular phenotypes. The study here aimed to investigate clinical presentations and variant effects associations in the disorder.Methods: We reported 10 Chinese pediatric patients with KCNB1-related neurodevelopmental disorder here. Functional experiments on newly reported variants, including electrophysiology and protein expression, were performed in vitro. Phenotypic, functional, and genetic data in the cohort and published literature were collected. According to their variants' molecular phenotypes, patients were grouped into complete or partial LoF, and DN effect or non-dominant-negative (non-DN) effect to compare their clinical features.Results: Nine causative KCNB1 variants in 10 patients were identified in the cohort, including eight novel and one reported. Epilepsy (9/10), global developmental delay (10/10), and behavior issues (7/10) were common clinical features in our patients. Functional analyses of 8 novel variants indicated three partial and five complete LoF variants, five DN and three non-DN effect variants. Patient 1 in our series with truncated variants, whose functional results supported haploinsufficiency, had the best prognosis. Cases in complete LoF group had earlier seizure onset age (64.3 vs. 16.7%, p = 0.01) and worse seizure outcomes (18.8 vs. 66.7%, p = 0.03), and patients in DN effect subgroup had multiple seizure types compared to those in non-DN effect subgroup (65.5 vs. 30.8%, p = 0.039).Conclusion: Patients with KCNB1 variants in the Asian cohort have similar clinical manifestations to those of other races. Truncated KCNB1 variants exhibiting with haploinsufficiency molecular phenotype are linked to milder phenotypes. Individuals with complete LoF and DN effect KCNB1 variants have more severe seizure attacks than the other two subgroups.
Theoretical Explanation of Upper Limb Functional Exercise and Its Maintenance in Postoperative Patients With Breast Cancer
Authors: Zhang Chi , Lu Ningning , Qin Shimeng , Wu Wei , Cheng Fang , You Hua 
Published: January 2022

Background: Upper limb functional exercise (ULFE) has a positive effect on promoting the rehabilitation of upper limb function. However, little is known, about what drives postoperative patients to engage in and even maintain the advised exercises. This study integrated the health action process approach (HAPA) and the theory of planned behavior theory (TPB) to investigate the psychosocial determinants on the initiation and maintenance of ULFE in breast cancer patients. In addition, this study also tests key hypotheses relating to reasoned and implicit pathways to ULFE and its maintenance among postoperative patients with breast cancer.Methods: Purposive sampling was used to recruit patients from two breast cancer wards in a provincial hospital in Jiangsu, China. Patients (N = 430) completed self-reported questionnaire about constructs from integrated theories concerning ULFE at an initial time point (T1): task self-efficacy, positive outcome expectations, negative outcome expectations, risk perception, attitude behavior, subjective norm, perceived behavioral control, behavioral intention, and ULFE-in hospital (ULFE-IH). Three months later (T2), patients self-reported: maintenance self-efficacy, action planning, coping planning, recovery self-efficacy, and ULFE-maintenance (ULFE-M).Results: The model has a good fit (GoF = 0.48). For behavioral intention of ULFE, subjective norm (β = 0.35) and perceived behavioral control (β = 0.61) were positively directly related to behavioral intention. Regarding the initiation of ULFE, perceived behavioral control (β = 0.47) and behavioral intention (β = 0.42) had a direct positive relation to ULFE-IH. In the maintenance of ULFE, action planning (β = 0.30), coping planning (β = 0.21), maintenance self-efficacy (β = 0.32), and recovery self-efficacy (β = 0.09) all had significant positive relation on ULFE-M. In addition, maintenance self-efficacy had a significant positive association on action planning (β = 0.80), coping planning (β = 0.74), and recovery self-efficacy (β = 0.67). Coping planning was significantly predicted by behavioral intention (β = 0.07). Additionally, behavioral intention is a mediator of subjective norm (β = 0.14) and perceived behavioral control (β = 0.25) to ULFE-IH. Action planning, coping planning, and recovery self-efficacy are mediators of maintaining self-efficacy to ULFE-M (β = 0.46).Conclusions: This study presents the first attempt to integrate the health behavior model in ULFE in postoperative patients with breast cancer. The study has shown that the HAPA-TPB integrated model has good applicability and effectiveness to explain and predict ULFE initiation and maintenance. Future work can be considered to develop appropriate intervention strategies based on this integrated behavioral theory.
Gender Differences in COVID-19 Lockdown Impact on Mental Health of Undergraduate Students
Authors: Amerio Andrea , Bertuccio Paola , Santi Francesca , Bianchi Davide , Brambilla Andrea , Morganti Alessandro , Odone Anna , Costanza Alessandra , Signorelli Carlo , Aguglia Andrea , Serafini Gianluca , Capolongo Stefano , Amore Mario 
Published: January 2022

Background: Prolonged university closures and social distancing-imposed measures due to the COVID-19 pandemic obliged students to at-home learning with online lectures and educational programs promoting potential social isolation, loneliness, hopelessness, and episodes of clinical decompensation.Methods: A web-based cross-sectional survey was carried out in a university institute in Milan, Northern Italy, to assess the COVID-19 lockdown impact on the mental health of the undergraduate students. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (CI) using adjusted logistic regression models.Results: Of the 8,177 students, 12.8% reported depressive symptoms, 25.6% anxiety, 8.7% insomnia, and 10.6% reported impulsive tracts, with higher proportions among females than males. Mental health symptoms were positively associated with caring for a person at home, a poor housing quality, and a worsening in working performance. Among males compared with females, a poor housing quality showed a stronger positive association with depressive symptoms and impulsivity, and a worsening in the working performance was positively associated with depressive and anxiety symptoms. In addition, the absence of private space was positively associated with depression and anxiety, stronger among males than females.Conclusions: To our knowledge, this is the first multidisciplinary consortium study, involving public mental health, environmental health, and architectural design. Further studies are needed to confirm or refute our findings and consequent recommendations to implement well-being interventions in pandemic conditions.
Applied Behavior Analysis as Treatment for Autism Spectrum Disorders: Topic Modeling and Linguistic Analysis of Reddit Posts
Authors: Bellon-Harn Monica L. , Boyd Ryan L. , Manchaiah Vinaya 
Published: January 2022

Background: It is critical for professionals to understand the discourse landscape within various online and social media outlets in order to support families of children with autism in treatment decision-making. This need is heightened when considering treatments that have garnered excitement and controversy, such as applied behavioral analysis (ABA) therapy.Method: The specific aims of this study were to identify the main themes in Reddit posts about ABA-based interventions for autism using topic modeling, to examine the linguistic aspects of Reddit conversations using the Linguistic Inquiry and Word Count (LIWC) analysis, and to examine the relationship between linguistic aspects and user category (i.e., pro- vs. anti-ABA vs. undecided, parent vs. professional vs. an individual with autism).Results: The topic modeling resulted in 11 themes that ranged across various elements, such as autism as a condition and its management, stakeholders, and consequences of autism and the support needed. The posts of individuals were focused on personal experiences and opinions as opposed to clinical and research information sharing. Linguistic analysis indicated that the posts reveal an intimate stance rather than an empirical stance.Conclusions: Results provide insight into perspectives of ABA. This type of research may help in developing and distributing appropriate and evidence-based information.
Case Report: Bionic Reconstruction in an Adult With Obstetric Brachial Plexus Injury
Authors: Boesendorfer Anna , Sturma Agnes , Gstoettner Clemens , Pittermann Anna , Laengle Gregor , Aszmann Oskar C. 
Published: January 2022

Introduction: Many adults who had a severe Narakas IV obstetric brachial plexus injury (OBPI) suffer from extensive impairments in daily living due to limited hand-arm function. The dramatic loss of axonal support at this very early age of development often render the entire extremity a biologic wasteland and reconstructive methods and therapies often fail to recover any functional hand use. In this scenario bionic reconstruction, including an elective amputation and a subsequent prosthetic fitting, may enable functional improvement in adults suffering from the consequences of such severe brachial plexus injuries. We here describe our experience in treating such patients and lay out the surgical rational and rehabilitation protocol exemplified in one patient.Case Presentation/Methods: A 27-year-old adult with a unilateral OBPI contacted our center. He presented with globally diminished function of the affected upper extremity with minimal hand activity, resulting in an inability to perform various tasks of daily living. No biological reconstructive efforts were available to restore meaningful hand function. An interdisciplinary evaluation, including a psychosocial assessment, was used to assess eligibility for bionic reconstruction. Before the amputation and after the prosthetic fitting functional assessments and self-reported questionnaires were performed.Results: One month after the amputation and de-rotation osteotomy of the humerus the patient was fitted with a myoelectric prosthesis. At the 1.5 year-follow-up assessment, the patient presented with a distinct improvement of function: the ARAT improved from 12 to 20 points, SHAP score improved from 8 to 29, and the DASH value improved from 50 to 11.7. The average wearing times of the prosthesis were 5 to 6 h per day (on 4–5 days a week).Discussion: The options for adults suffering from the consequences of severe OBPIs to improve function are limited. In selected patients in whom the neurological deficit is so severe that biologic hand function is unsatisfactory, an elective amputation and subsequent restoration of the hand with mechatronic means may be an option. The follow-up results indicate that this concept can indeed lead to solid hand function and independence in daily activities after amputation, subsequent prosthetic fitting, and rehabilitation.
Multiple Splenic Artery Aneurysms: A Case Report and Review of the Literature
Authors: Chen Wen Chun , Wang Tie hao , Yuan Ding , Zhao Ji Chun 
Published: January 2022

Background: Multiple splenic artery aneurysms (MSAAs) are rare and there are few reports about their treatment. We herein present a rare case of MSAAs treated with splenectomy combined with endovascular embolization.Methods: A 51-year-old female patient was incidentally diagnosed with MSAAs. Splenectomy combined with endovascular embolization was the chosen treatment.Outcomes: The patient recovered uneventfully and was discharged from the hospital 5 days after splenectomy. The patient has been doing well during the 27-months of follow-up.Conclusion: Combined with the experience of the previous literature, we think splenectomy combined with endovascular embolization is a safe, reliable and minimally invasive treatment for some selected multiple SAAs, depending on several patient parameters, such as the age, sex, aneurysm dimension, aneurysm location, complications, and severity of the clinical findings.
BAGAIMANA NUMBERED HEADS TOGETHER DAPAT MEMOTIVASI DAN MEMENUHI KEMAMPUAN MINIMUM LITERASI MEMBACA
Authors: Kholidi Putri Handayani 
Published: January 2022

Data menunjukkan bahwa kemampuan literasi membaca Indonesia tidak jauh berbeda dengan PISA. Secara keseluruhan, di antara 61 negara peserta survei, literasi membaca Indonesia menempati urutan ke-60 dalam hal literasi membaca. Menurut hasil Program Evaluasi Nasional Indonesia 2016 yang dilakukan oleh Pusat Penelitian Pendidikan Kementerian Pendidikan dan Kebudayaan, data menunjukkan bahwa rata-rata nasional sebaran literasi membaca siswa Indonesia adalah 46,83%. Hanya 6 0,06% termasuk kategori baik dan 47,11 termasuk kategori cukup. Hal ini mendorong peneliti dan pendidik untuk menggali metode pembelajaran yang dapat meningkatkan kemampuan literasi membaca minimal. Penelitian ini akan fokus pada bagaimana metode numbering dapat meningkatkan motivasi dan kemampuan membaca peserta didik. Penelitian ini dilakukan melalui penelitian mendalam terhadap literatur-literatur terkait dengan numbered heads together yang diterbitkan baik di dalam negeri maupun di luar negeri. Temuan utama dari penelitian ini adalah berkumpulnya sejumlah orang secara bersama-sama dapat merangsang semangat peserta didik, karena dapat meningkatkan kerjasama dan memberikan kesempatan untuk berbagi ide dan mempertimbangkan jawaban yang benar.
ROLE OF WORK ENVIRONMENT AND ORGANIZATIONAL CULTURE TO JOB PERFORMANCE
Authors: Putra Arif Rahman , Hariani Mila , Nurmalasari Dita , Irfan Mochamad , Hakim Yusuf Rahman Al 
Published: January 2022

ABSTRACT
Improving the quality of human resources is focused on a variety of things that can affect job performance. There are two variables that are thought to have contributed to the formation of job performance, namely the work environment and organizational culture. This study aims to analyze and determine the effect of the work environment and organizational culture on job performance. The research will be conducted in one of the micro businesses in Kranggan District, Mojokerto Regency which involves 25 employees to be involved as respondents. Multiple linear regression analysis is used as an analytical tool to prove the research hypothesis. The research findings suggest that (1) the work environment has a significant effect on job performance; (2) organizational culture has a significant effect on job performance; and (3) work environment and organizational culture simultaneously have a significant effect on job performance.
Keywords: work environment, organizational culture, job performance
CHANGE BUSINESS MODEL OF ISLAMIC RELIGIOUS COLLEGE BUSINESS IN EAST JAVA BY BUILDING INTEGRATED ONLINE POLICY AND TECHNOLOGY SYSTEMS DURING THE COVID-19 PANDEMIC PERIOD
Authors: M.said Ilham , Heri Cahyo Bagus Setiawan  , Nuzulul Fatimah  , Tatag Herbayu L  
Published: January 2022

This study conducted an analysis and evaluation of business services activities P erguruan T Heigh under the Ministry of Religious Affairs in J awa T imur to create a model of an integrated online system to maximize kan activities of the service business during a pandemic covid 19. Enterprises college business has expanded rapid and during the pandemic covid has made changes to the service online, after the application of social distance in an effort to deal with the spread of the disease corona virus (Covid-19). Initially, an increase in people's interest to shop online was to buy necessities of life very high with many transaction processes. The aim is to provide effective and efficient services to all business transactions conducted online during the pandemic covid19. The methodology used is a qualitative research method with case studies and using purposive samples . The analytical approach used is interpretive analysis. The results of the research show that implementing an integrated online system is able to serve many business transaction processing activities which are greatly improved. So it can be concluded several things as follows: With an integrated online system through planning and organizing business systems can illustrate the various classifications of implementation of business services online business activities in order to facilitate all forms of business transaction processes quickly, effectively and efficiently during Covid-19. System integration of online ie business opportunities using technology that can deliver greater value for the business of the college that the college of business can be developed and can be maintained as well as helping people to meet their needs and facilitate online transactions.