bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interrupted time series analysis using autoregressive integrated moving average (ARIMA) models: Effects of air pollution control policies on intracerebral hemorrhage mortality in Tianjin, China
Authors: Xu Jiahui , Yin Xiaolin , Jiang Tingting , Wang Shiyu , Wang Dezheng 
Published: November 2022

Abstract
Background: This research aims to quantitively evaluate the associations between air pollution control policies in Beijing-Tianjin-Hebei region and intracerebral hemorrhage (ICH) deaths in Tianjin and provide scientific evidence for the prevention and control of ICH as well as the management of air pollution.
Methods: This study used an interrupted time series analysis. Based on the data of ICH death cases in Tianjin collected by the Tianjin Center for Disease Control and Prevention, Autoregressive integrated moving average models (ARIMA) were fitted to assess the changes in ICH deaths before and after the interventions of air pollution control policies.
Results: There were 63,944 ICH deaths in Tianjin from 2009 to 2020, with an overall decreasing trend in ICH mortality. The secular trend change of the intervention in June 2014 was statistically significant (p = 0.03), with 0.69 (1.30 to 0.07) fewer ICH deaths per month. The immediate change of the intervention in October 2017 was statistically significant (p = 0.04), with 25.74 (50.62 to 0.85) fewer deaths from ICH in the month. A statistically significant immediate change in the intervention in December 2017 (p = 0.04), with 26.58 (-52.02 to -1.14) fewer deaths from ICH in the month. Moreover, a statistically significant immediate change in the intervention in March 2018 (p = 0.02), the number of ICH deaths decreased by 30.40 (56.41 to 4.40) in the month. After the interventions, an estimated 5984.76 ICH deaths (8.56%) were prevented.
Conclusion: The interventions of air pollution control policies during the study period were significantly associated with the reductions in ICH deaths in Tianjin. Surviving ICH patients and women were more sensitive to the protective effects of the interventions. Public health gains can be achieved by implementing interventions of air pollution control policy in cities with high levels of air pollution.
Horse Chestnut Tree Genome Reveals the evolutionary mechanism of Aescin and Aesculin biosynthesis
Authors: Sun Wei , Yin Qinggang , Wan Huihua , Xiong Chao , Xie Chong , Meng Xiangxiao , Wang Caixia , Gao Ranran , Chen Weiqiang , Xie Ziyan , Xue Zheyong , Yao Hui , Sun Peng , Xie Xuehua , Hu Zhigang , Nelson David , Xu Zhichao , Sun Xinxiao , Chen Shilin 
Published: November 2022

Abstract
Medicinal trees provide a main resource for diverse medicinal compounds. However, the biosynthesis of tree metabolites and their pathway evolution has gained limited understanding. Horse chestnut (Aesculus chinensis) is an important medicinal tree and its seeds are rich in aescins, barrigenol-type triterpenoid saponins (BAT), and aesculin, a coumarin glycoside, which are effective in the therapy of chronic venous insufficiency and asthenopia (eye strain). To understand the biosynthesis of these compounds, herein, we assembled a 470.04-Mb high-quality horse chestnut genome and characterized an Aesculus-specific whole-genome duplication (WGD) event. Spatial metabolome imaging, co-expression, and biosynthetic gene cluster analyses indicated that the Aesculus-specific WGD event led to the formation of two gene clusters (BGCs) including oxidosqualene cyclase, cytochrome P450 monooxygenase, cellulose synthase-derived glycotransferases, and BADH acyltransferases. Further biochemical investigation revealed the roles of AcOCS6, AcCYP716A278, AcCYP716A275, AcCSL1, and AcBAHD3 genes distributed between these two BGCs in catalyzing the formation of aescins. To understand the evolution of BAT pathways, the collinearity analysis showed the collinear BGC segments could be traced back to early-diverging angiosperms, then the essential gene-encoding enzymes necessary for the BAT biosynthesis were recruited before the split of Aesculus, Acer, and Xanthoceras. Meanwhile, we identified three UDP-glucosyltransferases and demonstrated their involvement in the biosynthesis of aesculin via a de novo synthesis. Taken together, these findings provide important information in understanding the evolution of gene clusters associated with medicinal tree metabolites.
Assessment of the Compressive Mechanical Behaviour of Injection Molded E-Glass/Polypropylene by Mechanical Testing and X-Ray Computed Tomography
Authors: Stamopoulos Antonios , Gazza Francesco , Neirotti Giuseppe 
Published: November 2022

Abstract
Nowadays, thermoplastic composite materials are considered among the most promising ones as they are gaining the interest of many industrial sectors due to their eco-friendly features such as their recyclability and their low-cost demand while being produced in high volumes. Especially in the automotive industry, there have always been used injection molded thermoplastics reinforced with glass fibers. Among the most concerning issues regarding the injection molded, short fiber-reinforced composites are the fiber distribution, the fiber orientation, and their effect on the overall mechanical performance. In the present work the effect of the injection molding on the compressive properties is investigated experimentally. To this context, compressive mechanical tests have been conducted in a range between sub-zero and elevated temperatures. In addition, X-Ray computed tomography is implemented for characterizing some crucial features. Among them, the fiber volume fraction, in local and global scale, and the orientation of the fibers through the thickness and length of the material are investigated.
Multi-objective integrated optimization study of Prefabricated building projects introducing sustainable levels
Authors: Peng Junlong , Feng Yue , Zhang Qi , Liu Xiangjun 
Published: November 2022

Abstract
As construction becomes greener, people have higher and higher requirements for engineering project management, which
makes it necessary to deeply study the comprehensive optimization of schedule, cost and sustainability level. Adhering to
the concept of low carbon and green, the article takes carbon emission factor into the total cost of building construction and
improves the traditional cost objective of engineering projects; then quantitatively analyzes the economic, environmental
and social impacts of assembled buildings from the perspective of sustainability, and introduces the sustainability objective
into the traditional duration-cost problem study, taking the duration of each job in the double code arrow diagram as the
independent variable to construct the duration -cost-sustainability level multi-objective optimization model. In order to solve the
type effectively, a series of Pareto optimal solutions are obtained using the NSGA-II algorithm, and the efficacy coefficient
method is used for program decision making. The results show that the Pareto solution set can provide effective support for the
project manager’s decision making, and the NSGA-II algorithm is effective in solving the multi-objective optimization model.
Continuous Symmetry Breaking in a Trapped-Ion Spin Chain
Authors: Monroe Christopher , Feng Lei , Katz Or , Haack Casey , Maghrebi Mohammad , Gorshkov Alexey , Gong Zhexuan , Cetina Marko 
Published: November 2022

Abstract
One-dimensional systems exhibiting a continuous symmetry can host quantum phases of matter with true long-range order only in the presence of sufficiently long-range interactions. In most physical systems, however, the interactions are short-ranged, hindering the emergence of such phases in one dimension. Here we use a one-dimensional trapped-ion quantum simulator to prepare states with long-range spin order that extends over the system size of up to $23$ spins and is characteristic of the continuous symmetry-breaking phase of matter. Our preparation relies on simultaneous control over an array of tightly focused individual-addressing laser beams, generating long-range spin-spin interactions. We also observe a disordered phase with frustrated correlations. We further study the phases at different ranges of interaction and the out-of-equilibrium response to symmetry-breaking perturbations. This work opens an avenue to study new quantum phases and out-of-equilibrium dynamics in low-dimensional systems.
First-principles calculations of equilibrium Ga isotope fractionations between several important Ga-bearing minerals and aqueous solutions
Authors: Zhang Jixi 
Published: November 2022

Abstract
This study predicts the equilibrium isotope fractionation factors for some important Ga-bearing species, including major minerals, aqueous solutions and gas phase systems. Equilibrium isotope fractionations of Ga are investigated by using first-principles quantum chemistry method at B3LYP/6-311 + G(d) level. The 1000ln(RPFR)s of Orthoclase, Albite, Quartz, Kaolinite, Forsterite, Montmorillonite, Gibbsite, Cassiterite, Aragonite, Sphalerite and Calcite are calculated with the method of the volume variable cluster model (VVCM). The 1000ln(RPFR)s of these minerals decrease in the order of Orthoclase > Albite > Quartz > Kaolinite > Forsterite > Montmorillonite > Gibbsite > Cassiterite > Aragonite > Sphalerite > Calcite. The solvation effect of Ga3+-bearing aqueous species is modeled by the water-droplet method and the 1000ln(RPFR)s of Ga3+-bearing aqueous species decrease in the order of [Ga(OH)4]−>[Ga(OH)3]>[Ga(OH)]2+>[Ga(OH)2]+>[Ga(H2O)6]3+. The calculation results show that equilibrium isotope fractionations of Ga between different minerals, solutions and gas phases are appreciable. Among minerals, Ga isotope fractionation has the largest value between Orthoclase and Calcite. Ga isotopic fractionation factor between these two minerals can reach 3.18 per mil at 100°C. Ga isotope fractionation between Ga-bearing aqueous species and minerals are important to give some information about the different geochemistry processes such as surficial geochemistry. This study has provided those important Ga isotope fractionation factors.
Test conditions of texture profile analysis for frozen dough
Authors: Dou Xinlai , Ren Xuyang , He Yinyuan , Liu Linlin , Zhang Guang , Sun Ying , Zhang Na , Chen Fenglian , Yang Chunhua 
Published: November 2022

Abstract
Wheat flour is more important for making frozen dough, this paper firstly conducted basic property of six wheat flour from different place and found BDHhgwf is more suitable to make frozen dough. Basic on it, texture profile analysis (TPA) has been put into applications in dough-made food industry, while the effects of the texture analysis parameters on properties of frozen dough were firstly investigated in this study. The results showed during TPA determination process of frozen dough, the variation of test parameters have an influence on the final result to some extent. The use of texture profile analysis (TPA) on frozen dough is addressed. The recommended test conditions are: pre-test speed 3.0 mm/s, test speed 1.0 mm/s, post-test speed 1.0 mm/s, and compression ratio 50%.
Study on the anode catalytic performance of graphenepolyaniline composites on direct methanol fuel cells
Authors: Wang Yixue , Qin Qi , He Fang , Chen Jing , Wu Changze 
Published: November 2022

Abstract
The aim of this study is to develop a noble metal dispersion-free anodic catalyst for one-step electrochemical synthesis of graphene/polyaniline (GP) composites using a mixture of graphene suspension and aniline monomer as the precursor by the potentiostat method. UV-vis (UV-VIS) spectroscopy and FT-IR (FT-IR) spectroscopy were used to characterize the structure of polyaniline (PANI) and GP. Cyclic voltammetry (CV) was used to test the electrochemical properties and electrocatalytic properties of polyaniline (PANI) and GP for methanol oxidation. The characterization results proved that the GP composite was successfully synthesized. The CV test curve showed that the electrochemical performance of the GP composite was significantly higher than that of PANI, with a larger specific capacity, which proved that the synergistic effect of the two composites was better played by the composite. However, the catalytic performance test for methanol oxidation showed that. The graphene/polyaniline (GP) composite has little catalytic effect on methanol oxidation.
Research on functional recovery training of adolescents based on the influence of balance force
Authors: Yang Xiwen 
Published: November 2022

Abstract
Dynamic balance is particularly important for maintaining, transforming and re-stabilizing various postures of the human body. In the process of sports, athletes need to have the ability to move quickly and continuously high intensity confrontation. Combined with the characteristics of adolescent physical function development, this paper aims at the problem that adolescent athletes have poor dynamic balance ability and cannot maintain the stability of the body center of gravity in the process of fast multi-direction motion and braking. Through the Y-Balance test and FMS test of 30 football players, the paired sample T test was carried out by the control experiment to compare whether there were significant differences in test indexes between the experimental group and the control group before and after the experiment. Independent sample t-test was conducted on the test indexes of the experimental group and the control group before and after the experiment to explore the influence of balance training on the physical function of adolescents.
Results: (1) the balance ability of the experimental group improved more than that of the control group, and there was a significant difference;(2) There is a significant difference in the total score of FMS test in the experimental group before and after the experiment (P = 0.01), while there is no significant difference in the total score of FMS test in the control group before and after the experiment.
Conclusion: Enhanced balance training can significantly improve the balance ability of adolescent athletes, help to improve the basic movement pattern,and it is of great significance for developing basic joint flexibility and stability and strengthening weak chain muscles.
Allogenic and Autologous anti-CD7 CAR-T cell Therapies in Relapsed or Refractory T-Cell Malignancies
Authors: Zhang Yinqiang , Li Chenggong , Du Mengyi , Jiang Huiwen , Luo Wenjing , Tang Lu , Kang Yun , Xu Jia , Wu Zhuolin , Wang Xindi , Huang Zhongpei , Wu Di , Chang Alex , Hu Yu , Mei Heng 
Published: November 2022

Abstract
Chimeric antigen receptor-T (CAR-T) therapy remains to be investigated in T-cell malignancies. CD7 is an ideal target for T-cell malignancies but is also expressed on normal T cells, which may cause CAR-T cell fratricide. Donor-derived anti-CD7 CAR-T cells using endoplasmic reticulum retention have shown efficacy in patients with T-cell acute lymphoblastic leukemia (ALL). Here we launched a phase I trial to explore differences between autologous and allogeneic anti-CD7 CAR-T therapies in T-cell ALL and lymphoma. Ten patients were treated and 5 received autologous CAR-T therapies. No dose-limiting toxicity or neurotoxicity was observed. Grade 1–2 cytokine release syndrome occurred in 7 patients, and grade 3 in 1 patient. Grade 1–2 graft-versus-host diseases were observed in 2 patients. Seven patients had bone marrow infiltration, and 100% of them achieved complete remission with negative minimal residual disease within one month. Two-fifths of patients achieved extramedullary or extranodular remission. The median follow-up was 6 (range, 2.7–14) months and bridging transplantation was not administrated. Patients treated with allogeneic CAR-T cells had higher remission rate, less recurrence and more durable CAR-T survival than those receiving autologous products. Allogeneic CAR-T cells appeared to be a better option for patients with T-cell malignancies.
Magnesium deficiency stress in rice can be alleviated by partial nitrate nutrition supply
Authors: Deng Na , Shang Qingyin , Zhu Hongyan , Gong Shidao , Qian Beibei , Yang Xiuxia 
Published: November 2022

Abstract
Magnesium (Mg) plays an imperative role in determining crop growth and development, but Mg-deficiency becomes more common, more severe and more widespread in farmland. The major source of nitrogen for rice is ammonium (NH4+). However, excessive application of NH4+ could inhibit Mg2+ uptake by rice. It has been accepted that partial nitrate (NO3-) nutrition may not only improve nitrogen (N) assimilation and rice growth, but also promote Mg2+ absorption. Nonetheless, the mechanisms underlying Mg and N interaction are not well documented. To explore the relationship between them in rice plant, a hydroponic experiment was conducted with different Mg (0.01, 1.00, and 5.00 mM) concentrations and various NO3-/NH4+ ratios (0/100, 25/75 and 50/50, %) under greenhouse conditions. Results showed that Mg-deficiency (0.01 mM) can cause yellow leaves, dwarf plants and fewer tillers during rice growth. Furthermore, Mg-deficiency treatment induced a major decrease in dry weight, root morphology and activity, photosynthetic properties, and Mg and N accumulation, while increase in antioxidant enzyme (MDA, SOD, POD and CAT) activities in rice, when compared with the high Mg (5.00 mM) or normal Mg (1.00 mM) treatment. The treatments with different NO3-/NH4+ ratios had no significant effect on these antioxidant enzyme activities in most cases under high or normal Mg conditions. However, under Mg-deficiency stress, the supply of partial NO3- lead to a significant drop in antioxidant enzyme activities. Moreover, partial NO3- supply significantly improved Pn, Tr, Gs and Ci under Mg-deficiency conditions. In particular, under Mg-deficiency stress, the supply of partial NO3- dramatically promoted the growth of the root system, boosted the occurrence of lateral roots, enhanced root vitality. Additionally, the supply of partial NO3- lead to significant increases of dry weight and N and Mg accumulation under the stress of Mg-deficiency. The results of this study suggested that the symptoms of Mg-deficiency stress in rice can be alleviated by partial NO3- supply.
Mechanistic Insights of NAC1 Nuclear Export and Its Role in Ovarian Cancer Resistance to Docetaxel
Authors: Zhang Yi , Dong ShunLi , Wang Xiao-Hui , Yang ShuMin , Guo FanFan , Zhang JingJing , Ji Cheng , Shi LiangRong , Cheng Yan , Hu Yan-Wei , Li ZhenYun , Peng Lei , Guo Ling-Chuan , Zhu Wei-Dong , Ren XC , Yang Jin-Ming 
Published: November 2022

Abstract
In this study, we uncovered the nuclear export of nucleus accumbens-associated protein-1 (NAC1) as a novel mechanism involved in ovarian cancer resistance to taxanes, the chemotherapeutic drugs commonly used in treatment of this malignancy. We showed that NAC1, a nuclear factor of the BTB/POZ gene family, has a nuclear export signal (NES) at the N terminus (aa 17-28), and this NES critically contributes to the NAC1 nuclear-cytoplasmic shuttling when tumor cells were treated with docetaxel. Mechanistically, the nuclear-exported NAC1 bound to cullin3 (Cul3) and cyclin B1 via its BTB and BOZ domains respectively, and the cyto-NAC1-Cul3 E3 ubiquitin ligase complex promotes the ubiquitination and degradation of cyclin B1, thereby facilitating mitotic exit and leading to cellular resistance to docetaxel. We also showed in in vitro and in vivo experiments that TP-CH-1178, a membrane-permeable polypeptide against the NAC1 NES motif, blocked the nuclear export of NAC1, interfered with the degradation of cyclin B1 and sensitized ovarian cancer cells to docetaxel. This study not only reveals a novel mechanism by which the NAC1 nuclear export is regulated and cyclin B1 degradation and mitotic exit are impacted by the NAC1-Cul3 complex, but also provides the nuclear-export pathway of NAC1 as a potential target for modulating taxanes resistance in ovarian cancer and other malignancies.
Perceived social support and posttraumatic growth among couples coping with gynecological cancer: A cross-sectional survey
Authors: Zhou Lihua , Stenmarker Margaretha , Henricson Maria , Li Ziye , Dai Yu , Hong Jingfang , Browall Maria 
Published: November 2022

Abstract
Background
Perceived social support was considered to be an essential resource of individual’s positive consequences (e.g., posttraumatic growth, PTG) during times of stressful conditions. However, there is no evidence on the relationship between perceived social support and PTG at the couple-based level in cancer research. This study aimed to explore the relationship between perceived social support and posttraumatic growth among couples coping with gynecological cancer.
Methods
A cross-sectional survey was conducted in China, from May 2019 to March 2020 in two comprehensive hospitals. A total of 126 couples, consisting of women diagnosed with gynecological cancer and their spouses, participated. The Multidimensional Scale of Perceived Social Support (MSPSS) and the Posttraumatic Growth Inventory (PTGI) were used to collect data. Paired t-tests, pearson’s correlations and actor-partner interdependence model (APIM) were used to analyze data.
Results
The actor effects of perceived social support on posttraumatic growth were supported (r = 0.419, p < 0.001; r = 0.467, p < 0.001); however, the partner effects of perceived social support on posttraumatic growth were not supported (r = -0.119, p༞0.05; r = 0.130, p༞0.05). Perceived social support was positively correlated between women diagnosed with gynecological cancer and their spouses (r = 0.244, p < 0.01). Furthermore, spouses’ perceived social support was positively correlated with women’s posttraumatic growth (r = 0.213, p < 0.05).
Conclusions
The actor effects of perceived social support on posttraumatic growth in couples coping with GC are supported. The findings also highlight that spouses’ perceived social support are positively correlated with women’s perceived social support and women’s PTG. Healthcare professionals should provide couple-based interventions that would increase couples’ identification and use of effective social support, and how to promote their PTG should be focused.
Clinical utilization of blinatumomab in Chinese monocentric patients with relapsed or refractory B-cell acute lymphoblastic leukemia
Authors: Zhu Jingkui , Fan Jixin , Xie Tiantian , Zhao Haiqiu , Lu Runqing , Zhang Yinyin , Li Yingmei , Xie Xinsheng , Wan Dingming , Jiang Zhongxing , Song Yongping , He Fei , Guo Rong 
Published: November 2022

Abstract
Purpose: Blinatumomab has promising applications in treating relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). However, there are few studies on using blinatumomab for treating R/R B-ALL patients in China. Therefore, we evaluated the efficacy and safety of blinatumomab among Chinese R/R B-ALL patients.
Methods: In total, 39 R/R B-ALL patients who received blinatumomab between October 2021 and August 2022 were selected as the study subjects. The primary endpoints include overall response rate (ORR) and complete minimal residual disease (MRD) response. Secondary endpoints included overall survival (OS) and adverse events (AEs).
Results: The ORR and OS for 19 patients with less than 5% bone marrow (BM) blasts were 63.2% and 11 months (7.3–14.7), respectively. The median OS for the 20 patients was unavailable, and 17 (or 85%) had a full MRD response. Twenty-seven patients (69.2%) reported having at least 1 AE. Hematologic toxicity and infections were the most common AEs. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed on nine patients who had been remission-free for a long time. In the first month, one patient (11.1%) developed thrombotic microangiopathy associated with HSCT (TA-TMA) following transplantation.
Conclusion: In R/R B-ALL patients, blinatumomab is an effective option in China.