bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan E-Modul Personality of Nabi Muhammad SAW pada Materi PAI Kebudayaan Islam Kelas IV SD
Authors: Apriansah Ardi , Rahmani Shofia Aina , Wahyuni Siti , Aeni Ani Nur 
Published: May 2022

The lack of motivation and interest of students in carrying out the learning process is caused by the lack of variety of learning media used by teachers. This study aims to assist teachers in interpreting learning tools and increase interest and motivation in studying PAI subjects for grade IV Personality of the Prophet Muhammad SAW. This study uses the Design and Development (D&D) method, has the following stages: (1) identification of problems, (2) describing objectives, (3) product design and development, (4) product testing, (5) evaluation of test results, and (6) communicating test results. The place of research was conducted at SDN Karapyak with a sample of 10 Class IV students. The result of product development was the E-Module “Personality of the Prophet Muhammad SAW. The results of the validation of the Principal and PAI teachers regarding this E-Module product are 88% included in the very good category so that it is feasible to use, besides that it is supported by the post-test results obtained from the quiz with an average score of 80 included in the good category. from the assessment that the E-Module "Personality of the Prophet Muhammad SAW Class IV" is very feasible to be used as a learning tool.
Keywords: E-Modul, Personality of Nabi Muhammad SAW, PAI

Kurangnya motivasi serta ketertarikan peserta didik dalam melakukan proses pembelajaran disebabkan karena minimnya variasi media pembelajaran yang di pakai oleh guru. Penelitian ini bertujuan untuk membantu guru dalam menginterpretasikan prangkat pembelajaran dan meningkatkan minat serta motivasi dalam mempelajari mata pelajaran PAI kelas IV materi Kepribadian Nabi Muhammad SAW. Penelitian ini menggunakan metode Design and Development (D&D), mepunyai tahapan : (1) identifikasi masalah, (2) mendeskripsikan tujuan, (3) desain dan pengembangan produk, (4) uji coba produk, (5) evaluasi hasil ujicoba, dan (6) mengomunikasikan hasil uji coba. Tempat penelitian dilakukan di SDN Karapyak 1 dengan sampel sebanyak 10 orang siswa Kelas IV. Hasil pengembangan produk merupakan E-Modul "Personality Of Nabi Muhammad SAW. Hasil validasi oleh Kepala Sekolah dan Guru PAI terkait produk E-Modul ini yaitu 88%, masuk dalam kategori sangat baik sehingga layak untuk digunakan. Selain itu didukung dengan hasil post-test yang diperoleh dari kuis dengan rata-rata nilai 80 termasuk pada kategori baik. Dapat disimpulkan dari hasil penilaian bahwa E-Modul "Personality Of Nabi Muhammad SAW Kelas IV sangat layak digunakan sebagai sarana pembelajaran
Kata Kunci: E-Modul, Kepribadian Nabi Muhammad SAW, PAI
Handbook of Florida Water Regulation: Florida Department of Environmental Protection
Authors: Olexa Michael T. , Broome Zachary 
Published: May 2022

Lost in the maze of statutes, regulations, and potential liabilities that identify the current mass of water protection law? This revised document is part of the Handbook of Florida Water Regulation, which consists of 2-4 page fact sheets that provide an accurate, current, and authoritative summary of the principal, federal, and state (Florida) laws that directly or indirectly relate to agriculture. It provides a basic overview of the many rights and responsibilities that farmers and farmland owners have under both federal and state laws as well as the appropriate contact information to obtain more detailed information. Written by Michael T. Olexa and Zachary Broome, with contributions by Tatiana Borisova, and published by the UF Department of Food and Resource Economics, June 2011.
FE593/FE593: 2021 Handbook of Florida Water Regulation: Florida Department of Environmental Protection (ufl.edu)
Penilaian Presentasi Infografis Materi Pedagogi Seni Pertunjukan untuk Mendukung Pembelajaran Zoom Meeting
Authors: Pratama Ujang Nendra , Herbekti Silvia 
Published: May 2022

<p class="16bIsiAbstrak">Pembelajaran utama secara daring sampai saat ini masih dilaksanakan di semua tingkat dan jenis pendidikan, tak terkecuali di pendidikan tinggi kesenian. Terkait hal ini, pengajar perlu memanfaatkan teknik-teknik instruksional yang dapat mendukung kinerja secara daring. Peneliti telah melakukan implementasi pendekatan <em>synchronous</em> pembelajaran daring dengan aplikasi Zoom Meeting di lingkungan Prodi Pendidikan Seni Pertunjukan. Berangkat dari hal tersebut, maka telah diterapkan teknik instruksional dengan presentasi infografis untuk penyampaian materi melalui kelas Zoom. Penelitian ini bertujuan untuk mengetahui kelayakan desain presentasi berbasis infografis tentang materi pedagogi (pendidikan dan pembelajaran) seni pertunjukan dari sudut pandang ahli media. Metode riset yang dilakukan adalah validasi ahli atau survei pakar (<em>experts judgement survey</em>). Pengambilan data melalui survei daring dengan instrumen kuesioner yang terdiri dari 4 kategori penilaian (total item 32). Sumber data adalah sepuluh ahli media dari kalangan dosen Teknologi Pembelajaran. Analisis data dilakukan melalui penjumlahan rerata skor hasil survei, kemudian membagi ke setiap total kategori dan total skor per responden, serta mengonversi ke 4 kategori nilai kualitas. Hasil penelitian menunjukkan bahwa presentasi infografis yang diimplementasikan memiliki nilai kelayakan tinggi. Pembuatan presentasi infografis dalam implementasi penelitian ini menyesuaikan berbagai macam rekomendasi dari penelitian sebelumnya, sehingga media yang dihasilkan memiliki kelayakan tinggi dari persepsi ahli. Studi ini menyimpulkan bahwa desain presentasi berbasis infografis tentang materi kependidikan dan pembelajaran untuk pendidikan seni pertunjukan, telah dinyatakan layak dari sudut pandang ahli media. Hasil studi ini diharapkan dapat memberikan implikasi pada pengajaran materi kependidikan dan pembelajaran untuk kawasan bidang studi lain yang masih relevan. Penelitian mendatang dapat diarahkan untuk survei persepsi dari sudut pandang peserta didik yang menjadi audiens dari pemanfaatan media terkait.</p><p class="16bIsiAbstrak"> </p>
Peluang Dan Tantangan Implementasi Merdeka Belajar Kampus Merdeka (Mbkm) Di Fakultas Teknik Dan Sains UIKA BOGOR
Authors: Hudjimartsu Sahid Agustian , Prayudyanto Muhammad Nanang , Permana Setya , Heryansyah Arien 
Published: May 2022

Dinamika dan perubahan yang terjadi saat ini begitu dinamis, terlebih di era revolusi industri 4.0 atau disebut sebagai revolusi digital yang diindikasikan oleh perubahan yang sangat besar di semua bidang berbasis teknologi. Perubahan juga terjadi di bidang Pendidikan yang mana dituntut dapat berjalan beriringan sesuai dengan perubahan yang ada agar dapat menghasilkan sumber daya daya manusia pendidikan tinggi yang memiliki kualitas tinggi yang juga inovatif, kreatif, dan efisien. Oleh karena itu, untuk menghadapi kondisi tersebut Kementerian Pendidikan dan Kebudayaan membuat kebijakan terkait Pendidikan diantaranya kebijakan Merdeka Belajar Kampus Merdeka (MBKM). Kebijakan MBKM memberikan kebebasan dan otonomi kepada Lembaga Pendidikan, dan merdeka dari birokratisasi, dosen dibebaskan dari birokrasi yang berbelit serta mahasiswa diberikan kebebasan dalam memilih bidang yang mereka minati. Terjadi pergeseran bentuk pembelajaran sehingga menjadi peluang dan tantangan bagi perguruan tinggi dalam memfasilitasi model pembelajaran yang mampu menghadapi tantangan jaman dan menuju kampus yang bermutu dan bereputasi.
Mengatasi Problematika Pembelajaran Daring Pada Siswa Sekolah Dasar Melalui Pendekatan Psychological Well Being (PWB)
Authors: Asmahasanah Salati , Priatna Oking Setia , Supriatna Irfan 
Published: May 2022

<p>Tujuan peneltian ini adalah untuk menggambarkan berbagai problematika dampak dari pembelajaran daring serta membahas proses penanganan melalui pendekatan <em>Psychological Well Being (PWB) </em>pada anak sekolah dasar dan tergambar dengan jelas fenomena perubahan perilaku siswa akibat pembelajaran daring. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan metode deskriptif. Peneliti memperoleh data bahwa sebagian besar guru memanfaatkan gawai (HP) dalam pembelajaran online namun hal yang mengkhawatirkan adalah adanya generasi dengan <em>learning loss</em> karena penurunan capaian belajar. Banyak siswa yang mengalami kesulitan konsentrasi, dan rasa berat sekali beban karena banyak sekali penugasan dari guru guna untuk menuntaskan kurikulumnya, dan juga peningkatan rasa stres, cemas, apatis dan jenuh yang dialami siswa. Hasil penelitian yang ditemukan bahwa <em>Psychological Well Being (PWB) </em>dapat membantu anak untuk menumbuhkan emosi positif, kepuasan hidup dan kebahagiaan mengurangi berprilaku negatif dan dapat mengendalikan emosi dengan baik.</p>
Developing the polycystic kidney disease interactome
Authors: Brauer Mackenzie 
Published: May 2022

<p>Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disease causing numerous renal cysts to form leading to adult renal failure. The PKD-causing genes, polycystic kidney disease-1 and -2 (PKD1 and PKD2), encode for proteins polycystin-1 and -2 (PC1 and PC2). These proteins form a complex through their C-termini at cilia with mutations abolishing their interaction and impairing ciliary localization. We report the first use of proximity-dependent biotinylation for identification (BioID) to characterize the PC1 PC2 C-terminal complex binding partners in HEK 293 cells. We identify high- confidence interacting partners including an enrichment of cilia-related, transporter activity and trafficking genes. We report interesting PC1 interactions including Biogenesis of Lysosome-Related Organelles Complex-1 (BLOC-1) subunits and BLOC-One-Related Complex (BORC) subunits. We also report endoplasmic reticulum (ER)-related proteins that likely contribute to PC2 ER localization and function. Overall, this research hopes to contribute information to how PC1 and PC2 traffic and function at cilia.</p>
<p><br></p>
Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
Authors: Hua Rui , Gu Sumin , Jiang Jean X. 
Published: May 2022

Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming osteoblasts. In this study, two newly developed osteocytic cell lines, OCY454 and IDG-SW3, were used to determine the role of Cx43 gap junctions and hemichannels (HCs) in the regulation of osteoblast to osteocyte differentiation. We found that the Cx43 level was substantially increased during the differentiation of IDG-SW3 cells and is also much higher than that of OCY454 cells. We knocked down Cx43 expression using the lentiviral CRISPR/Cas9 approach and inhibition of Cx43 HCs using Cx43 (E2) antibody in IDG-SW3 cells. Cx43 knockdown (KD) or Cx43 HC inhibition decreased gene expression for osteoblast and osteocyte markers, including alkaline phosphatase, type I collagen, dentin matrix protein 1, sclerostin, and fibroblast growth factor 23, whereas increasing the osteoclastogenesis indicator and the receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG) ratio at early and late differentiation stages. Moreover, mineralization was remarkably attenuated in differentiated Cx43-deficient IDG-SW3 cells compared to ROSA26 control. The conditioned medium collected from fully differentiated IDG-SW3 cells with Cx43 KD promoted osteoclastogenesis of RAW264.7 osteoclast precursors. Our results demonstrated that Cx43 HCs play critical roles in osteoblast to osteocyte differentiation process and regulate osteoclast differentiation via secreted factors.
Early Combination of Albumin With Crystalloid Administration Might Reduce Mortality in Patients With Cardiogenic Shock: An Over 10-Year Intensive Care Survey
Authors: Zou Zhi-ye , Wang Bin , Peng Wen-jun , Zhou Zhi-peng , Huang Jia-jia , Yang Zhen-jia , Zhang Jing-jing , Luan Ying-yi , Cheng Biao , Wu Ming 
Published: May 2022

BackgroundIn updated international guidelines, combined albumin resuscitation is recommended for septic shock patients who receive large volumes of crystalloids, but minimal data exist on albumin use and the optimal timing in those with cardiogenic shock (CS). The objective of this study was to evaluate the relationship between resuscitation with a combination of albumin within 24 h and 30-day mortality in CS patients.MethodsWe screened patients with CS from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Multivariable Cox proportional hazards models and propensity score matching (PSM) were employed to explore associations between combined albumin resuscitation within 24 h and 30-day mortality in CS. Models adjusted for CS considered potential confounders.E-value analysis suggested for unmeasured confounding.ResultsWe categorized 1,332 and 254 patients into crystalloid-only and early albumin combination groups, respectively. Patients who received the albumin combination had decreased 30-day and 60-day mortality (21.7 vs. 32.4% and 25.2 vs. 34.2%, respectively,P&lt; 0.001), and the results were robust after PSM (21.3 vs. 44.7% and 24.9 vs. 47.0%, respectively,P&lt; 0.001) and followingE-value. Stratified analysis showed that only ≥ 60 years old patients benefited from administration early albumin. In the early albumin combination group, the hazard ratios (HRs) of different adjusted covariates remained significant (HRs of 0.45–0.64,P&lt; 0.05). Subgroup analysis showed that resuscitation with combination albumin was significantly associated with reduced 30-day mortality in patients with maximum sequential organ failure assessment score≥10, with acute myocardial infarction, without an Impella or intra-aortic balloon pump, and with or without furosemide and mechanical ventilation (HRs of 0.49, 0.58, 0.65, 0.40, 0.65 and 0.48, respectively;P&lt; 0.001).ConclusionThis study found, compared with those given crystalloid-only, resuscitation with combination albumin within 24 h is associated with lower 30-day mortality of CS patients aged≥60. The results should be conducted to further assess in randomized controlled trials.
An Online Tool Using Basal or Activated Ovarian Reserve Markers to Predict the Number of Oocytes Retrieved Following Controlled Ovarian Stimulation: A Prospective Observational Cohort Study
Authors: Han Yong , Xu Huiyu , Feng Guoshuang , Alpadi Kannan , Chen Lixue , Wang Haiyan , Li Rong 
Published: May 2022

BackgroundPredicting the number of oocytes retrieved (NOR) following controlled ovarian stimulation (COS) is the only way to ensure effective and safe treatment in assisted reproductive technology (ART). To date, there have been limited studies about predicting specific NOR, which hinders the development of individualized treatment in ART.ObjectiveTo establish an online tool for predicting NOR.Materials and MethodsIn total, 621 prospective routine gonadotropin releasing hormone (GnRH) antagonist COS cycles were studied. Independent variables included age, body mass index, antral follicle counts, basal FSH, basal and increment of anti-mullerian hormone, Luteinizing hormon, estradiol, testosterone, androstenedione, and inhibin B. The outcome variable was NOR. The independent variables underwent appropriate transformation to achieve a better fit for a linear relationship with NOR. Pruned forward selection with holdback validation was then used to establish predictive models. Corrected Akaike’s information criterion, Schwarz–Bayesian information criterion, scaled –log[likelihood], and the generalized coefficient of determination (R2) were used for model evaluation.ResultsA multiple negative binomial regression model was used for predicting NOR because it fitted a negative binomial distribution. We established Model 1, using basal ovarian reserve markers, and Model 2, using both basal and early dynamic markers for predicting NOR following COS. The generalized R2 values were 0.54 and 0.51 for Model 1 and 0.64 and 0.62 for Model 2 in the training and validation sets, respectively.ConclusionModels 1 and 2 could be applied to different scenarios. For directing the starting dose of recombinant follicle stimulation hormone (rFSH), Model 1 using basic predictors could be used prior to COS. Model 2 could be used for directing the adjustment of rFSH dosages during COS. An online tool (http://121.43.113.123:8002/) based on these two models is also developed. We anticipate that the clinical application of this tool could help the ART clinics to reduce iatrogenic ovarian under- or over-responses, and could reduce costs during COS for ART.
The Chemokines Initiating and Maintaining Immune Hot Phenotype Are Prognostic in ICB of HNSCC
Authors: Huang Yuhong , Liu Han , Liu Xuena , Li Nan , Bai Han , Guo Chenyang , Xu Tian , Zhu Lei , Liu Chao , Xiao Jing 
Published: May 2022

Background: The immune checkpoint blockade (ICB) with anti-programmed cell death protein 1(PD-1) on HNSCC is not as effective as on other tumors. In this study, we try to find out the key factors in the heterogeneous tumor-associated monocyte/macrophage (TAMM) that could regulate immune responses and predict the validity of ICB on HNSCC.Experimental Design: To explore the correlation of the TAMM heterogeneity with the immune properties and prognosis of HNSCC, we established the differentiation trajectory of TAMM by analyzing the single-cell RNA-seq data of HNSCC, by which the HNSCC patients were divided into different sub-populations. Then, we exploited the topology of the network to screen out the genes critical for immune hot phenotype of HNSCC, as well as their roles in TAMM differentiation, tumor immune cycle, and progression. Finally, these key genes were used to construct a neural net model via deep-learning framework to predict the validity of treatment with anti-PD-1/PDL-1Results: According to the differentiation trajectory, the genes involved in TAMM differentiation were categorized into early and later groups. Then, the early group genes divided the HNSCC patients into sub-populations with more detailed immune properties. Through network topology, CXCL9, 10, 11, and CLL5 related to TAMM differentiation in the TME were identified as the key genes initiating and maintaining the immune hot phenotype in HNSCC by remarkably strengthening immune responses and infiltration. Genome wide, CASP8 mutations were found to be key to triggering immune responses in the immune hot phenotype. On the other hand, in the immune cold phenotype, the evident changes in CNV resulted in immune evasion by disrupting immune balance. Finally, based on the framework of CXCL9-11, CLL5, CD8+, CD4+ T cells, and Macrophage M1, the neural network model could predict the validity of PD-1/PDL-1 therapy with 75% of AUC in the test cohort.Conclusion: We concluded that the CXCL9, 10,11, and CCL5 mediated TAMM differentiation and constructed immune hot phenotype of HNSCC. Since they positively regulated immune cells and immune cycle in HNSCC, the CXCL9-11 and CCL5 could be used to predict the effects of anti-PD-1/PDL-1 therapy on HNSCC.
Autoimmune Skin Disease Exacerbations Following COVID-19 Vaccination
Authors: Sprow Grant , Afarideh Mohsen , Dan Joshua , Feng Rui , Keyes Emily , Grinnell Madison , Concha Josef , Werth Victoria P. 
Published: May 2022

BackgroundVaccination against COVID-19 reduces the risk of severe COVID-19 disease and death. However, few studies have examined the safety of the COVID-19 vaccine in patients with autoimmune skin disease.ObjectivesWe sought to determine the incidence of disease exacerbation in this population following COVID-19 vaccination as well as the associated factors.MethodsWe performed a chart review of all patients seen in the autoimmune skin disease clinic of the principal investigator during the study period. All patients included for analysis were systematically and prospectively asked about COVID-19 vaccination status, manufacturers, vaccine dates, autoimmune symptoms after the vaccine, and timing of symptom onset using a standardized template as part of their visit. Demographics and autoimmune disease diagnosis were also collected. Analysis used Chi-square and Fisher’s exact tests.Results402 subjects were included for analysis. 85.6% of patients were fully vaccinated, with 12.9% unvaccinated and 1.5% partially vaccinated. 14.8% of fully vaccinated patients reported worsening autoimmune signs and symptoms after the vaccine. Fully vaccinated dermatomyositis patients were more likely to report worsening autoimmune signs and symptoms after the vaccine (22.7%) than fully vaccinated lupus erythematosus patients (8.6%) (p=0.009). Patients fully vaccinated with the Moderna vaccine trended towards an increased likelihood of reporting worsening autoimmune signs and symptoms after the vaccine (19.1%) than those with the Pfizer-BioNTech vaccine (12.0%) (p=0.076). Of the patients who had autoimmune symptoms after vaccination, 20% had symptoms after the 1st dose, 82% after the 2nd dose, and 4% after the 3rd dose with median onset (95% confidence interval) of 7 (2,14), 14 (14,21), and 18 (7,28) days later, respectively.ConclusionsMore fully vaccinated dermatomyositis patients had exacerbation of autoimmune signs and symptoms after the vaccine than fully vaccinated lupus erythematosus patients. However, given the risks of COVID-19, clinicians should still promote vaccination in most patients with autoimmune skin disease.
Single-Cell Sequencing of Immune Cell Heterogeneity in IgG4-Related Disease
Authors: Wu Xunyao , Peng Yu , Li Jieqiong , Zhang Panpan , Liu Zheng , Lu Hui , Peng Linyi , Zhou Jiaxin , Fei Yunyun , Zeng Xiaofeng , Zhao Yan , Zhang Wen 
Published: May 2022

BackgroundThe IgG4-related disease (IgG4-RD) is an immune-mediated disorder with fibrotic manifestations. However, the transcriptional profiles of immune cell subsets at single-cell level are unknown. Herein, single-cell sequencing was used to assess the specific cell subpopulations and pathways in peripheral blood mononuclear cells (PBMCs) of IgG4-RD.MethodsSingle-cell sequencing was performed using the PBMCs from four patients with IgG4-RD and three healthy controls (HCs). Functional enrichment and cell analysis were performed through re-clustering of PBMCs to assess functional pathways and intercellular communication networks in IgG4-RD. Western blot and flow cytometry were used to verify sequencing and functional enrichment results.ResultsFour major cell types and 21 subtypes were identified. Further subclustering demonstrated that plasma B-cell proportions increased with increasing glycolysis/gluconeogenesis activity in IgG4-RD. Re-clustering of myeloid cells showed that EGR1 and CD36 expressions were significantly increased in CD14+ monocytes of IgG4-RD, as validated by Western blot analysis. Moreover, tumor necrosis factor (TNF) production pathways were positively regulated in CD14+ monocytes of IgG4-RD. In vitro stimulation showed that CD14+ monocytes of IgG4-RD could secrete higher levels of TNF-α . Notably, the proportions of CD8 central memory T (TCM) and TIGIT+ CD8 cytotoxic T (CTL) increased in patients with IgG4-RD compared with HCs. Further interaction analysis showed that B cell activation factor (BAFF) signaling pathways were enriched from myeloid cells subsets to B cells.ConclusionThis study enhances the understanding of the cellular heterogeneity and transcriptional features involved in the pathogenesis of IgG4-RD, providing key clinical implications.