bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and psychopathological features of patients with type II diabetes mellitus
Authors: Kondratenko A. 
Published: January 2022

Today, type II diabetes mellitus (T2DM) is considered to be the most important nosological cause of decreased cognitive functions. A number of studies have found that hyperglycemia and duration of diabetes are associated with cognitive deficits, with the prevalence of cognitive impairment in type 2 diabetes mellitus being 20% in men and 18% in women over 60 years of age.
To achieve this goal, it was conducted a comprehensive clinical-psychopathological and psychodiagnostic examination of 82 patients with moderate type 2 diabetes mellitus (46 women and 36 men) aged 35.9±10.1 years in accordance with the principles of bioethics and deontology. The mean duration of diabetes was 7.9±5.2 years. The severity of diabetes in most cases was defined as moderate (84.1%), and in 15.9% of cases corresponded to severe. 30.2% of patients used insulin as a basic hypoglycemic therapy, 69.8% - tablets.
According to the analysis of the emotional state of patients with T2DM were characterized by complaints of low, depressed mood (69.5% of examined patients), uncontrolled emotional reactions (46.2%), feelings of anxiety, constant internal tension (44.7%), paresthesias (29.1%), sleep-wake cycle disorders (56.2%), general weakness, lethargy and fatigue (58.2%), fatigue (90.0%), frequent mood swings, with a predominance of decreased mood background (23.3%), emotional lability with excessive vulnerability and sensitivity (16.6%), irritability (16.6%).
The clinical and psychopathological structure of emotional disorders is represented by anxious (43.4%), depressive (26.6%), astheno-hypochondriac (19.8%), hysteroform (10.2%) syndromes. Clinical examination of patients with DM showed that more often (in 95.0% of cases) in patients with T2DM there is a decrease in memory of auditory and visual modality, impaired intellectual abilities, slow thinking, lack of attention and information processing.
Morphometric aspects of studying the features of remodeling of atrial structures at postresection portal hypertension
Authors: Gdanska N. , Hnatjuk M. , Tatarchuk L. , Monastyrska N. 
Published: January 2022

Introduction. Removal of the left and right lateral lobes of the liver in white rats leads to postresection portal hypertension, which is characterized by dilation and plethora of the hepatic portal vein, mesenteric veins, esophageal and gastric veins, veins of the anterior abdominal wall, splenomegaly, ascites and multiorgan failure.
Objective of the research: to study the features of remodeling of the structures of the atria at postresection portal hypertension histostereometrically.
Materials of the research and their discussion. The peculiarities of remodeling the structures of the atria were histostoreometrically studied in 65 adult white male rats, which were divided into 3 groups: the 1- consisted of 20 intact animals, the 2 – 30 rats with postresection portal hypertension, which was modeled by removal of the left and right lateral lobes of the liver, the 3 – 15 animals with postresection portal hypertension and multiorgan failure. One month after the start of the experiment, rats were euthanized by bloodletting under conditions of thiopental anesthesia. Histological micropreparations were used to determine the diameters of cardiomyocytes of the left and right atria, diameters of their nuclei, nuclear-cytoplasmic relations, relative volumes of cardiomyocytes, capillaries, stroma, stromal-cardiomyocyte, capillary-cardiomyocyte relations, relative volumes of damaged cardiomyocytes. Quantitative indicators were processed statistically.
Results of the research and their discussion. Histostereometrically, it was found that postresection portal hypertrophy leads to hypertrophy of atrial cardiomyocytes, their nuclei, growth of stromal structures, relative volumes of damaged cardiomyocytes, disorders of tissue and cellular structural homeostasis. The revealed features of remodeling of the studied structures dominated in the left atrium at combination of postresection portal hypertension with multiorgan failure.
Conclusions. Postresection portal hypertension leads to pronounced remodeling of the structures of the left and right atria, characterized by hypertrophy of cardiomyocytes, changes in their nuclear-cytoplasmic relations, an increase of the relative volume of stroma, damaged cardiomyocytes, pronounced disorders of tissue and cellular structural homeostasis. The revealed morphological changes dominated in the left atrium at combination of postresection portal hypertension with multiorgan failure.
DNA typing of the gastric mucosa of patients with chronic duodenal ulcer
Authors: Kharchenko A. , Yelinska A. 
Published: January 2022

The work involved a molecular biological technique (ISSR-PCR) using ISSR-primer S-2, with structure (AGC) 6G. Changes in the gastric mucosa in chronic duodenal ulcer disease against the background of severe chronic atrophic gastritis have been analyzed. Noteworthy is the fact that there is a strong correlation between the degree of dysplasia of the epithelium of the gastric mucosa and the mitotic index, the Pearson's correlation coefficient rxy was 0.853, respectively. A strong and very strong correlation relationship between the indicators of the degree of dysplasia of the epithelium of the gastric mucosa by phenotypic characteristics and indicators of DNA typing of samples of the gastric mucosa, the Pearson's correlation coefficient rxy was 0.863, respectively.
DNA profiles of the gastric mucosa of patients with duodenal ulcer according to the results of typing by the ISSR-PCR method ranging from 520 to 620 bp. had the character of microsatellite expansions and differed from the profile of the norm, which is evidence of precancerous changes.
Sport as a Means of Promoting Universal Humanistic Values
Authors: Bilous Anton 
Published: January 2022

Aim. Conceptualization of the axiological potential of sport as an important social phenomenon that covers all levels of modern society. Material and methods. The theoretical and methodological basis of our study is: 1) works of Ukrainian and foreign scientists in the process of learning the essence of sport, its place in the socio-cultural space; 2) the results of modern cultural studies; 3) speculations of representatives of axiological knowledge. The specifics of the theoretical study also determined the need to involve a number of scientific approaches to the analysis of the phenomenon of sport: 1) systemic; 2) personality-oriented; 3) axiological; 4) culturological.
Results. The analysis of the special literature on the chosen topic provided the basis for: 1) determining the formation of humanistic values ​​of the task relevant to the society; 2) conceptualization of the basic conditions for the promotion of the following values ​​(gaining value experience by engaging in axiological knowledge and examples of success of life strategies based on humanistic values; involvement in the value reality, which formulates clear requirements for the individual in combination with creating conditions to meet its needs ); 3) appeal to sport as a specific phenomenon of cultural life and a source of a significant number of examples of success of life strategies based on humanistic values; 4) highlighting the potential of sport in terms of promoting universal humanistic values.
Conclusions. Special studies prove that the topic of humanistic values ​​does not lose relevance. Accordingly, the task is to ensure their promotion in society. There are reasonable grounds to claim that one of the means of solving this problem is modern sport. It is the social phenomenon that has the potential to provide the basic conditions for the promotion of humanistic values: 1) considerable space for gaining valuable experience; 2) effective involvement in the value reality.
Clinical and metabolic parameters, Ca2+, parathormone depending on serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population
Authors: Semianiv Marianna , Sydorchuk Larysa 
Published: January 2022

Introduction. Low plasma levels of 25-OH vitamin D (25(OH)D) have been associated with an increased prevalence of hypertension. The purpose of the research was to establish the association of clinical and metabolic parameters, Ca2+, parathormone and serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population. Material and method. 100 subjects with essential arterial hypertension (EAH) and target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved in the case-control study. Among them, 70,84% females, 29,16% males, mean age 57,86±7,81 yo. The control group consisted of 60 healthy individuals. All recruited patients were examined for heart rate, systolic and diastolic blood pressure (SBP, DBP); SCORE, BMI, waist and hip circumference (WC, HC); lipid panel, serum glucose and ionized calcium, 25(OH)D, parathormone levels were studied. Patients were divided into groups depending on total serum 25(OH)D concentration. Results. Low 25(OH)D concentration (<30 ng/ml) in patients with EAH was associated with arrhythmia, headache, sleep disturbance, weakness, fatigue, and increased total 10-year risk for fatal CVD SCORE>5,0%. We found higher SBP and DBP by 9,12% (р=0,014) and 5,17% (р=0,047), higher BMI in men and women – by 20-28,11% (р<0,05), as well as higher values of WC and HC by 8,69-11,92% (р<0,05) in hypertensive patients with hypovitaminosis D. In addition, obesity (BMI≥30,0 kg/m2), hyperglycemia, hypertriglyceridemia was more frequent – by 43% (p<0,05), 43,13% (p<0,001) and 59,37% (p=0,023), respectively. The level of ionized Ca2+ was slightly higher in healthy individuals (p=0,047) with low vitamin D concentration. PTH was compensatory increased by 31,85% (p=0,048) in hypertensive patients with hypovitaminosis D.
Conclussions. Hypovitaminosis D is associated with more severe metabolic, hemodynamic disorders and clinical symptoms in hypertensive patients in the West-Ukrainian population.
Proteomics
Authors: Dolomatov S. , Kazakova V. , Zukow W. 
Published: January 2022

Proteomics is a branch of molecular biology that deals with the identification and quantification of proteins in living objects, as well as the analysis of protein functions and their interactions.
Proteomics is studied by proteins that are expressed in a given cell, tissue or organism over a period of time (under certain conditions).
It is known that information about the primary structure of a protein (the sequence of amino acid residues in a protein) is contained in a structural gene in the form of a codon sequence (genetic code). On the other hand, less than 10% of genes are functionally active (expressed) in the somatic cells of our body. Moreover, a distinct tissue-specific expression of genes is observed. This, in turn, leads to the peculiarities of the qualitative composition of the synthesized proteins in various tissues. No less important is the fact that the total amount of proteins synthesized by our tissues is much greater than the total number of structural genes containing information about their original structure. This phenomenon is explained by the activity of such mechanisms as alternative splicing and a wide variety of post-translational peptide processing pathways (covalent modification of a polypeptide synthesized on the ribosome) in health and disease. Thus, even a brief review of the semantic content of the term "proteomics" indicates an extremely complex system of protein molecules in our body, which plays a fundamental role in maintaining homeostasis and is involved in the formation of adaptive responses in response to adverse changes in the internal and external environment.
Znaczenie wsparcia dla funkcjonowania psychofizycznego osób opiekujących się bliskimi z chorobą Alzheimera
Authors: Gałuszka Aleksandra 
Published: January 2022

Choroby neurodegeneracyjne to wrodzone bądź nabyte postępujące choroby układu nerwowego. Ich patologia wiąże się z utratą komórek nerwowych, zaś istota procesu chorobowego wiedzie do wystąpienia wielu objawów uszkodzeń neurologicznych, związanych z funkcją motoryczną (np. ataksja) oraz z pamięcią (demencja). Proces wiodący do pojawienia się objawów choroby neurodegeneracyjnej rozpoczyna się znacznie wcześniej, zanim się one pojawią. Przebiega często przez wiele lat i bywa bezobjawowy. Pierwsze symptomy pojawiają się gdy znacząca liczba neuronów ulegnie uszkodzeniu, bądź uszkodzenie dotyczy określonej części ośrodkowego układu nerwowego. Jedną z chorób neurodegradacyjnych jest choroba Alzheimera . Dotyczy głównie osób po 65. roku życia i dotyka 5-7% populacji. Czas jej trwania wynosi ok. 8-14 lat. Specyfiką choroby jest stopniowe i nieodwracalne zaburzenie homeostazy organizmu, zaburzenia procesów poznawczych i postępujący zanik pamięci, który prowadzi do zaburzeń orientacji wzrokowo-przestrzennej. Pojawiająca się apraksja skutkuje niemożnością posługiwania się przyborami codziennego użytku. W późnej fazie otępienie jest bardzo nasilone zaś pamięć często ograniczona jedynie do faktów autobiograficznych. Zaburzenia mowy są na tyle zaawansowane, że chory może wypowiadać pojedyncze słowa. Występują również zaburzenia emocjonalne, przejawiające się apatią lub agresywnością. Zaburzenia obejmują również problemy z przeżuwaniem, przełykaniem i kontrolą zwieraczy. Występowanie choroby w strukturze rodziny wywołuje liczne zmiany oraz wyrzeczenia ze strony jej członków.
Psychological determinants of the use of complementary and alternative medicine – CAM
Authors: Księska-Koszałka Joanna 
Published: January 2022

Wprowadzenie i cel pracy. Współcześnie obserwuje się rosnącą popularność medycyny komplementarnej i alternatywnej (complementary and alternative medicine – CAM). U podstaw zjawiska leży szereg uwarunkowań, które są przedmiotem zainteresowań nauk społecznych. Badania te napotykają na szereg metodologicznych trudności. Celem artykułu jest prezentacja psychologicznych uwarunkowań stosowania CAM w świetle literatury przedmiotu. Przedstawienie stanu wiedzy poprzedzono obszernym wstępem teoretycznym z uwagi na nikłość aktualnych polskich opracowań dotyczących omawianej tematyki w literaturze z zakresu psychologii zdrowia. Dokonano przeglądu prac badawczych z lat 1990-2021 w bazach danych dostępnych w zasobach Ebsco, tj. Medline, APA PsycArticles, APA PsycInfo, CINAHL; w wyszukiwarce Google Scholar; spisach piśmiennictwa znalezionych artykułów oraz w zasobach własnych.
Skrócony opis stanu wiedzy. Istniejących badań dotyczących zjawiska jest relatywnie niewiele, wyniki dotychczasowych badań niejednokrotnie są sprzeczne. Najlepiej poznanymi determinantami stosowania CAM są czynniki środowiskowe i poznawcze dotyczące stylów poznawczych i przekonań. Duże znaczenie mają również czynniki związane z duchowością i religijnością. Najmniej wiadomo na temat czynników osobowościowych i emocjonalnych.
Podsumowanie. Tematyka psychologicznych uwarunkowań stosowania CAM wymaga dalszych badań. Głębsze poznanie determinant zjawiska pozwoli na lepiej zrozumieć potrzeby i oczekiwania pacjentów, które stoją u podstaw postaw zdrowotnych.
Local and nonlocal Purcell factor control of an emitter in graphene under the modulation of a static magnetic field
Authors: Ma Zenghong , Chen Zijian , Zhang Lian , Lu Xiaocui , Xu Jian , Xu Xin , Yang Guangwu 
Published: January 2022

Spontaneous emission control of emitters holds great promise for applications in photonics and quantum optics. As a definition of the spontaneous emission lifetime of an atom or molecule, the Purcell factor of an emitter coupled with graphene controlled by a static magnetic field was studied. The results show that the Purcell factor can be effectively enhanced by applying an external magnetic field to graphene at low terahertz frequency. By analyzing the dispersion relations of graphene and the Purcell factor of an emitter nearby it, we find that the emitter-graphene interactions are most influenced by nonlocal effects at the low frequency, especially at a short emitter-graphene distance. The coupling between the emitter and the magnetic biased graphene becomes stronger under nonlocal effects, leading to a strong enhancement of the emission of the emitter. More specifically, the nonlocal Purcell factor can increase by orders of magnitude when the applied magnetic field is 10 T compared to the local model at a very short distance. The bias of the applied magnetic field extends a new path for the realization of Purcell factor modulation based on graphene-emitter interaction, and it may provide a promising application value for the design of the photo-magnetic-based quantum devices.
Optical trapping of nanoparticles in superfluid helium
Authors: Minowa Yosuke , Geng Xi , Kokado Keisuke , Sato Kentaro , Kameyama Tatsuya , Torimoto Tsukasa , Ashida Masaaki 
Published: January 2022

Although nanoparticles have been used to study the properties of superfluid helium as fluid tracers, the interaction between nanoparticles and superfluid helium has remained largely unexplored. This is due to the lack of a technique to precisely trap and manipulate nanoparticles in superfluid helium. Optical tweezers, the three-dimensional confinement of a nanoparticle by a strongly focused beam of light, have been widely employed in investigating biomaterial nanomechanics, nanoscopic fluid properties, and ultrasensitive detection in various environments such as inside living cells, at gigapascal pressure, and under high vacuum. However, the cryogenic operation of solid-state-particle optical tweezers is poorly understood. In this study, we demonstrate the optical trapping of metallic and dielectric nanoparticles in superfluid helium below 2 K, which is two orders of magnitude lower than in previous experiments. We prepare the nanoparticles via in situ laser ablation. The nanoparticles are stably trapped with a single laser beam tightly focused in the superfluid helium. Our method provides a new approach for studying nanoscopic quantum hydrodynamic effects and interactions between quantum fluids and classical nanoobjects.
Pengaruh Pola Asuh terhadap Perilaku Makan Anak Usia 4-6 Tahun
Authors: Nida Noor Maziyati , Hartanto Fitri 
Published: January 2022

Latar belakang. Perilaku makan yang terbentuk saat dewasa diawali oleh perilaku makan di usia anak-anak. Faktor lingkungan terdekat yang berpengaruh pada perilaku makan adalah keluarga diantaranya pola asuh orangtua. Beberapa penelitian menyebutkan terdapat hubungan pola makan remaja dengan pola asuh orangtua.Tujuan. Menganalisis hubungan pola asuh terhadap perilaku makan anak usia 4-6 tahun.Metode. Penelitian dengan desain cross-sectional, dilaksanakan di beberapa TK di Semarang dengan subyek orangtua dan anak usia 4-6 tahun yang memenuhi kriteria inklusi dan eksklusi. Pemilihan subyek dilakukan dengan teknik consecutive sampling dengan besar sampel sebanyak 153 subyek. Data perilaku makan diperoleh melalui Children Eating Behaviour Questionnaire (CEBQ), sedangkan data pola asuh melalui kuesioner pola asuh. Analisis data menggunakan uji koefisien kontingensi.Hasil. Sebanyak 125 (82,4%) anak mendapatkan pola asuh demokratis, 18 (11,1%) pola asuh otoriter dan 10 (6,5%) permisif, 72,5% di antaranya adalah penyuka makanan dan 27,5% penghindar makanan. Terdapat korelasi sangat lemah pola asuh demokratis terhadap terhadap perilaku makan (r=0,197;p=0,013). Terdapat korelasi sangat lemah pola asuh permisif terhadap terhadap perilaku makan (r=0,189;p=0,017).Tidak didapatkan korelasi yang bermakna antara pola asuh otoriter terhadap perilaku makan.Kesimpulan. Penelitian ini memberikan informasi dengan menunjukkan adanya pengaruh pola asuh demokratis dan permisif terhadap perilaku anak, tetapi tidak ada korelasi pada pola asuh otoriter.
Terapi Antikoagulan pada Anak
Authors: Chozie Novie Amelia , Sarita Raisa Cecilia 
Published: January 2022

Seiring berkembangnya pengobatan dan teknologi di rumah sakit seperti pemasangan akses vaskular, serta kondisi penyakit pada anak, maka faktor risiko kejadian trombosis pada anak juga semakin meningkat. Kejadian trombosis ini perlu penanganan berupa terapi antikoagulan yang bertujuan untuk menurunkan risiko emboli, mencegah komplikasi, dan profilaksis bagi individu yang berisiko. Penggunaan antikoagulan pada anak di praktik klinis sehari-hari sebagian besar menggunakan data ekstrapolasi dari hasil studi pada orang dewasa. Terbatasnya data yang ada saat ini dan sistem hemostasis anak yang berbeda dengan dewasa menyebabkan penggunaan antikoagulan pada anak menjadi tantangan khusus. Beberapa pilihan terapi antikoagulan masing-masing memiliki kelebihan dan kekurangannya baik dari sisi pengaturan dosis, frekuensi pemberian, pemantauan, efikasi dan efek samping. Tinjauan pustaka ini akan membahas penggunaan antikoagulan pada anak khususnya heparin (unfractionated heparin, low molecular weight heparin), warfarin, dan perkembangan studi antikoagulan oral baru, serta pada populasi khusus yaitu anak dengan keganasan, sindrom lupus eritematosus, dan infeksi virus SARS-COV-2.
DEVELOPMENT OF A METHOD FOR PRODUCING (-)-17-ALLYL-4,5Ά-EPOXY-3,14-DIHYDROXYMORPHINAN-6-ONE
Authors: Kalashnikov Aleksandr Ivanovich , Kulagina Dar'ya Aleksandrovna , Malykhin Valeriy Viktorovich , Sysolyatin Sergey Viktorovich 
Published: January 2022

Naloxone ((-)-17-allyl-4,5ά-epoxy-3,14-dihydroxymorphinan-6-one) is a pure opiate antagonist of a competitive type devoid of morphine-like activity and is widely used in clinical practice. The main raw material for the production of naloxone is thebaine, which is extracted from plant materials.
This study presents a seven-step process for preparing naloxone with a yield of 35% (based on thebaine). Previously known methods of obtaining are characterized by the yield of the target product in terms of thebaine not higher than 20%. The greatest losses are recorded at the stage of obtaining oxycodone from thebaine and at the stage of O-demethylation of codeine. The use of formic acid in the hydrogenation process provides a more complete conversion of the intermediate product, and the use of boron tribromide in the environment of chloroalkanes at the stage of O-demethylation leads to the production of naloxone with a yield of more than 70%.
A detailed study of the stages of obtaining oxycodone and noroxycodone allows to reduce the consumption of reagents and the time spent in the reactor, which is essential for reducing the cost of the final product.
The proposed method is superior to those known in terms of productivity and economic efficiency and can be used for the development of industrial technology for the production of naloxone and its derivatives.