bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of hemodynamic parameters of uterine spiral arteries in predicting Gestational Diabetes Mellitus in first trimester
Authors: Wang Lei , Chen Ping , Mao Xiaoyuan , Ren Min 
Published: May 2022

Abstract
Purpose Early diagnosis of GDM and targeted blood glucose control treatment are crucial to improve maternal and infant health and to reduce the incidence of adverse pregnancy events. There is a lack of simple, effective and accurate screening methods that can be performed before 14 weeks of gestation. This study aimed to investigate the value of hemodynamic parameters of spiral artery in predicting GDM at 11 ~ 13 + 6 weeks of gestation. Methods To investigate the value of hemodynamic parameters of uterine spiral artery in predicting GDM in first trimester. We conducted a prospective case–control study, involving 1054 singleton pregnancies in our obstetric clinic of Shanghai First Maternal and Infant Hospital from January 2020 to June 2021. According to the follow-up results, they were divided into normal group (938 cases) and GDM group (116 cases). All pregnant women examined by Doppler ultrasonography in first-trimester to measure uterine spiral arterial hemodynamic parameters, including pulsation index (PI), resistance index (RI), peak systolic flow velocity (PSV) and mean diastolic velocity(MDV). The hemodynamic parameters of the GDM group and normal group were compared, and ROC curve was drawn to evaluate the efficacy of uterine spiral artery PI in predicting GDM. Results The PI value of uterine spiral artery in GDM group was higher than that in normal group (0.88 ± 0.16 vs. 0.63 ± 0.17), and the difference was statistically significant (t = 14.932, P < 0.05). The PSV and RI in GDM group were slightly lower than those in normal group, but the differences were not statistically significant (P > 0.05). The area under ROC curve of spiral artery PI for predicting GDM was 0.861 (95%CI: 0.827–0.895, P < 0.05), and PI 0.675 was the optimal threshold. The sensitivity and specificity of spiral artery PI for predicting GDM were 90.5% and73.3%, respectively. Conclusions: The changes of uterine spiral artery hemodynamic parameters at first-trimester of pregnancy may be related to the occurrence of GDM, and the PI value of uterine spiral artery has certain value in predicting GDM.
Conversion of calcium hydroxide fouled with gases evolved from smokestack of glass industry to calcium hydroxyapatite
Authors: Hanna Adli , mousa sahar , fathi nady , Sherief Marwa , abdelmoaty alaa 
Published: May 2022

Abstract
Conversion of industrial wastes to valuable products has become a global requirement to reduce the pollution of environment. This study intended to utilize the solid waste of calcium hydroxide fouled with gases which produced from smokestacks of glass industry by using low-cost and simple procedure. In the current work, this waste was converted to calcium sulfate by treatment with sulfuric acid for preparation of calcium hydroxyapatite (HAp) nanoparticles. The produced HAp was characterized by X-ray diffraction (XRD) and fourier transform infrared spectroscopy (FTIR) to evaluate the crystalline structure and main functional groups. The thermal stability, the particle size and morphology were studied by thermal gravimetric analysis (TGA), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The obtained results confirmed that the produced HAp is well-crystalline, with main surface functional groups of hydroxyapatite which appeared as rods-like of particle size ranged from 11 to 15 nm. Also, the obtained HAp has Ca/P ratio of 1.60 and exhibited high total surface area of 146 m2/g with mesoporous structure leading to this material can be used in medical and water purification applications.
Biochemical profiling of Toko (Livinstonia jenkinsiana Griff.): an endangered underutilized fruit of North East India
Authors: T. Yatung , Veluru Bhargav , K.S. Shivashankara , G.A. Geetha , A.N. Lokesha 
Published: May 2022

Abstract
Livinstonia jenkinsiana Griff. is an endangered multi-purpose palm, mainly confined to the North-eastern states of India. Fruits of the palm are edible and used in chutney preparation by various tribes of northeastern India. Tribal farmers of Arunachal Pradesh are involved in cultivation and conservation of this species based on their traditional knowledge and economic benefits, completely unaware its nutritional attributes are. The metabolite profiling of the fruits from this unique palm was analyzed through gas chromatography-tandem mass spectrometry (GC-MS/MS) and liquid chromatography-mass spectrophotometry (LC-MS/MS). Palmitic acid (44.93%) followed by oleic acid (32.86%) was found to be the major fatty acids present in the fruit. Malvidin, an anthocyanin compound is responsible for peel colour of the fruit. Predominant sugar, organic acid, phenol, and flavonoid present in the fruit pulp are fructose, citric acid, gentisic acid, and rutin, respectively. The bioactive compounds present in the fruit pulp possess various health benefits. Thus, Livinstonia jenkinsiana can be exploited as a potential minor fruit crop for its various health-benefiting compounds for food and nutritional security.
From waste to valuable resources: exploitation of mineral waste in civil and environmental application.
Authors: Padoan Elio , Tefa Luca , Passarella Iride , Dino Giovanna Antonella 
Published: May 2022

Abstract
Mineral wastes coming from demolition activities, including rock and soil from excavations, and extractive industry, represent the first and the second source of waste production at EU level (35.9% and 26.6% respectively). Although some of these waste products can cause environmental and economic problems if not adequately managed and disposed, they represent an alternative resource for civil, building, infrastructure and environmental applications. This study introduces the state of the art of the research and applications of products arising from mineral waste, with a focus on new potential application of fine fractions for artificial substrate production. The agronomic characteristics of the produced mixes were tested to evaluate their use and the environmental criticalities for land rehabilitation. The results showed that, when mixed with organic materials, the overall quality and fertility of the mineral waste fine fraction was improved, and that this mixture was not phytotoxic. This indicates that when properly managed and treated the mineral waste fine fraction could be effectively employed for land rehabilitation. In general, both coarse and fine mineral waste fractions are valuable alternative construction materials for buildings infrastructures and environmental applications. Sustainable and circular management of mineral waste contributes to guarantee raw materials supply, contemporary reducing environmental (including CO2 production) impacts associated to waste management and landfilling. The potential decrement of environmental impacts and CO2 production will contribute to enhance the NET-zero greenhouse gas emissions EU strategy. Statement of Novelty The present research outlines the possible reuses of different mineral wastes coming from demolition activities and rocks and soils from excavation works as a replacement for natural aggregates, in line with the circular economy paradigm. These materials represent the first source of wastes (in mass) in Europe and innovative processes for their efficient reutilization are needed. This research addressed the main problems connected with their management, focusing on some experimental processes, such as the production of artificial substrates, as a sustainable alternative to contrast the land consumption. However, the updating of the current legislation and the inclusion of these new products for public works (Green Procurement) is regarded fundamental to the effective application of novel technologies.
Lung microbiota dynamics are associated with primary graft dysfunction in lung transplant recipients
Authors: Lian# Qiaoyan , Yi# Xinzhu , Yang# Yalan , Yang# Junhao , Cai Yuhang , Chen Ao , Xu Yu , Wang Xiaohua , Wang Zhang , He Jianxing , Ju Chunrong 
Published: May 2022

Abstract
Rationale: Primary graft dysfunction (PGD) is the most common complication and the leading cause of death in early-stage post lung transplantation. Lung microbiota dysbiosis has been revealed to contribute to allograft lung complications, but the association between lung microbiota and PGD remains unknown. Objectives: We performed a longitudinal survey in 20 lung transplant recipients (LTRs) at an early-stage post lung transplantation aimed to explore the association of lung microbiota with PGD. Methods: 16S rRNA gene sequencing was used to analyze the microbiota in bronchoalveolar lavage fluid. Results: We found decreased microbial alpha diversity with increased PGD severity on day seven post-transplantation. However, on days 14 and 30, the trend was reversed, with a positive association between alpha diversity and PGD severity, suggesting a gradual increase in microbial diversity during the first month post-transplantation. The microbial alpha diversity increased the most dramatically with severe PGD. The increased rates of Streptococcus and Stenotrophomonas were the highest in severe PGD LTRs, indicating rapid proliferation of pathogenic taxa in this subgroup. Rothia and Granulicatella showed continuously decreasing trends with increasing PGD severity, suggesting dysbiosis. Short-term outcomes showed that all LTRs survived 3 months post-transplantation, with severe PGD LTRs having a significantly longer hospital stay than the other groups (p = 0.006). Conclusions: Our results suggest that the lung microbiota is temporally dynamic post lung transplantation, and this dynamism, rather than the static microbiota composition at each time point, is associated with PGD grades. Increased PGD severity is associated with rapid dysbiosis and overgrowth of potentially respiratory pathogenic taxa post-transplantation.
Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4-5 KDIGO without renal replacement therapy: A double-blind randomized HEBE-CKD trial
Authors: Solis-Jimenez Fabio , Perez-Navarro Lucia Monserrat , Cabrera-Barron Ricardo , Chida-Romero Jesus Antonio , Martin-Alemañy Geovana , Dehesa-López Edgar , Madero Magdalena , Valdez-Ortiz Rafael 
Published: May 2022

Abstract
Background: The co-administration of loop diuretics with thiazide diuretics is a therapeutic strategy in patients with hypertension and volume overload. The aim of this study was to assess the efficacy and safety of treatment with bumetanide plus chlorthalidone in patients with chronic kidney disease (CKD) stage 4-5 KDIGO.Methods: A double-blind randomized study was conducted. Patients were randomized into two groups: bumetanide plus chlorthalidone group (intervention) and the bumetanide plus placebo group (control) both underwent follow-up at 30 days. The study’s registration number was NCT03923933.Results: Thirty-two patients with a mean age of 57.2±9.34 years and a median estimated glomerular filtration rate (eGFR) of 16.7 ml/min/1.73 m2 (2.2-29). There was decreased volume overload in the liters of total body water (TBW) on Day 7 (intervention: -2.5 vs. control: -0.59, p=0.003) and Day 30 (intervention: -5.3 vs. control: -0.07, p=0.016); and in liters of extracellular water (ECW) on Day 7 (intervention: -1.58 vs. control: -0.43, p<0.001) and Day 30 (intervention: -3.05 vs. control: -0.15, p<0.000). There was also a decrease in systolic blood pressure on Day 7 (intervention: -18 vs. control: -7.5, p=0.073) and Day 30 (intervention: -26.1 vs. control: -10, p=0.028) and in diastolic blood pressure on Day 7 (intervention: -8.5 vs. control: -2.25, p=0.059) and Day 30 (intervention: -13.5 vs. control: -3.4, p=0.018).Conclusion: In CKD stage 4-5 KDIGO without renal replacement therapy, bumetanide in combination with chlorthalidone is more effective in treating volume overload and hypertension than bumetanide with placebo.
An effective methodology for software defects prediction using Principal Component-based Multi-layer Perceptron (PC-MLP): A Hybrid Technique
Authors: Mustaqeem Mohd. , Siddiqui Tamanna 
Published: May 2022

Abstract
Nowadays, the software is used almost in every field. The software industry is evolving rapidly, and developing quality software is challenging for developers. Defects in the software are the primary reason for degrading the quality. Software defects prediction is a difficult task. Though researchers have developed several methods to overcome this issue that support the problem, there is room for improvement in software defects prediction. The curse of dimensionality occurs when research is undertaken without feature reduction. Therefore, after consulting several other works of a similar caliber, a hybrid machine learning approach that combines Principal Component Analysis (PCA) for feature optimization with Multi-layer perceptrons for classification has been designed to overcome the hurdle. The proposed model reduces the time complexity of the traditional methods by reducing the number of attributes used for classification. We have used the PROMISE dataset KC1 & CM1 repository from the NASA directory (KC1 2109 observations & CM1 344 observations) to perform our research work. We have divided the datasets into training (1476 from KC1 & 240 from CM1 observations) and testing (633 from KC1 & 104 from CM1 observations). We have employed precision, recall, F-measure, and accuracy in evaluating the model. Using the proposed model, we reduced the time complexity and increased the accuracy by 6% using the KC1 dataset and the previously proposed models. In addition, the proposed model receives a greater score on additional criteria. The primary limitation with Multi-layer perceptrons is that it requires a linearly separable dataset, which can make classifications relatively inflexible. Soon, several new strategies may be introduced to overcome this limitation and maintain a soft-based categorization margin.
Learner’s self-evaluation on performance rating in Linear Algebra at UPOU with asynchronous methods and synchronous meetings
Authors: MASUHAY EDILMAR PATAGAN 
Published: May 2022

Abstract
The purpose of the study showcases the Learner self-evaluation on performance rating as part of giving final grade by uncovering his personal experiences in his education about Linear Algebra at the UPOU. The study adopts and modify the theory of Rappe & Hayman (1996) on self-evaluation as the basis for rating performance, and used the conceptual framework introduced by Mahmood, Othman & Yusof (2012) in gathering data. Then, Grading Rubrics served as the basis for self-evaluation in giving final grade by proficiency indicated in the graphics presentation. In lieu to this study asked questions were hypothetically satisfied which revealed that the Learner compared his impressions about the subject prior and after he took the course; uncovered his difficulties and the causes in linear algebra; emphasized the real significance of the course by enumerating the techniques and skills he acquires which can be helpful on his future career; and described his participation in synchronous meetings with the asynchronous methods, reflected his understanding about the modules, homework, attendance to synchronous meetings, and relating the most helpful aspects about the course; provided self-evaluation on his performance rating from 0 to 100, with 100 being excellent and 60 being average, and justify his self-evaluation performance rating. Thus, based on the Grading rubrics his homework proficiency has accumulated with a total score of 329 over 400 with the equivalent percentage of 82.25% in Homework 1–6 which means within the range from 75–90% this result contemplated that Learner’s proficiency describes that his homework provides a complete, correct, rigorous proof or solution but is not that written well. Comprises also were an outcomes that from monitoring assessment on learning and teaching improvement, it has been recognized by a character that the learner has almost 100% in attendance to the synchronize meetings and participated, communicated in some instance important matters via emails, portal messenger; with complete compliance and perfect submission of homework and obtained a recognizable score by proficiency having 1 item with 60–80%, 1 item with 90–99%, and 9 items with 100%, and finally met a maximum rating score of 100% for final (summative) homework. Systematically, based on results from this study, the Learner’s performance rating probably can be computed anytime in the following criterion: Proficiency in Homework + Characteristic in the Learning Process + Monitoring Assessment on learning and teaching improvement + Learner's Principles in Linear Algebra (rated by the professor) of which the ultimate results for the Learner’s final grade, should be coming from the professor’s personal records and evaluation. Thus, the teacher’s objective criterion on giving final grade is the ultimate verdict.
Crystallization Mechanism and Removal of Mixed Solution in Drainage System of Dolomite Tunnel
Authors: Rao Junying , Xue Yanghao , Tao Yonghu 
Published: May 2022

Abstract
In the construction of tunnels located in the dolomite area, the problems caused by the blockage of the drain pipe (ditch) crystallize one after another. The blockage of the drain pipe (ditch) is one of the potential factors for the leakage of water in the tunnel. Therefore, it is of great engineering significance to find out the factors and mechanisms of crystallization of the dolomite tunnel drainage system. In this paper, the crystallization mechanism and crystal characteristics of the mixed solution of dolomite tunnel drainage system are analyzed based on geological investigation, water quality testing, crystal structure, etc., the causes of crystalline blockage of drainage pipes are analyzed by combining indoor model tests and crystallization breaking tests, and finally, the optimization suggestions of the drainage system are proposed. The results show that the water samples of the dolomite tunnel drainage pipeline belong to the mixed solution of multi-ions, the cations are Ca2+, Mg2+, Al3+, etc., and the anions are CO32−、HCO3−、SO42−, etc. Among them, the mass fraction and concentration of Ca2+, Mg2+, Al3+ are relatively high., while the mass fraction and concentration range of Fe3+、Cu2+、Zn2+、Ba2+ are approximately 0; the crystal powder contains Cl, O, S, K, Ca, Mg, Al, Na and other elements, and the content of Ca, Mg, Al In comparison, Ca is more, Al is less, and Mg is between the two; after the evaluation of the degree of crystallization blockage, it is found that the degree of blockage of the transverse drain pipe per linear meter is higher, the circular drainage pipe is lower, and the longitudinal pipe is between the two. The crystal removal effect is more significant with the increase of the ultrasonic vibration frequency. It is found that the optimal removal frequency is 50 kHz, and the optimization suggestion of the drainage system is given in combination with the "V"-shaped pipeline arrangement.
Study of the mechanism by which Sp1/CD146 induces UCA-PSCs angiogenesis through the WNT/β-catenin pathway
Authors: Yang yangyanjun , Zhu Lihua , Yao Changfang , Li Yuan , Chen Linlin , Ye Wenfeng , Zhang Chunxue 
Published: May 2022

Abstract
Background
Angiogenesis is a significant factor for the cure of ischemia diseases. We found that human umbilical cord vein perivascular stem cells (UCV-PSCs) and umbilical cord artery perivascular stem cells (UCA-PSCs) have markers of mesenchymal stem cells (MSCs) and multidifferentiation abilities similar to Wharton’s jelly mesenchymal stem cells (WJ-MSCs). Moreover, UCA-PSCs and UCV-PSCs have stronger angiogenesis ability and cell migration ability than WJ-MSCs, for which the regulatory mechanism remains unclear.
Results
The western blot data showed that, compared with that in WJ-MSCs, the expression of specific protein 1 (Sp1) and CD146 in UCV-PSCs and UCA-PSCs was upregulated, suggesting that Sp1 and CD146 may have an important role in angiogenesis in cell populations. By searching the GenBank promoter database, the binding site of Sp1 was found in the promoter of CD146. A proposed mechanism for angiogenesis is that Sp1 induces the UCA-PSCs angiogenesis process by activating the expression of CD146, which activates the Wnt/β-catenin signaling pathway. The β-catenin, GSK3β and p-GSK3β expression was upregulated in UCA-PSCs overexpressing CD146 and decreased in UCA-PSCs in which CD146 was silenced.
Conclusion
Our data demonstrated Sp1 activates the protein expression of CD146 in UCA-PSCs via the Wnt/β-catenin pathway mediating angiogenesis. These findings offer new ideas and strategies for the treatment of ischemic diseases.
Minimum dataset development for Hematopoietic stem cell transplantation (HSCT) recipient registry in Iran
Authors: Taheriyan Moloud , SafaeiNodehi SeyedReza , Kalhori Sharareh R. Niakan , Mohammadzadeh Niloofar 
Published: May 2022

Abstract
Background
The lack of a uniform minimum dataset (MDS) in Iran for recording and reporting the hematopoietic stem cell transplantation (HSCT) recipients across all treatment processes leads to determining a localized MDS by considering two well-known international MDS. This study describes the required MDS development for the hematopoietic stem cell transplantation recipient registry.
Method
The study was conducted in 2020–2021. An expert panel of three hematology and oncology specialists and three medical informatics were formed. After reviewing datasets of HSCT registries, focus groups, meetings, questionnaire development, and validation, an MDS was determined.
Results
The validated MDS comprises 1177 data elements in 9 sections, including pre-HSCT, leukemia, lymphoma, myelodysplastic syndrome, myeloproliferative neoplasms, combined myelodysplastic syndrome and myeloproliferative neoplasms, plasma cell disorders, hemoglobinopathy, and post-HSCT. The data elements were aggregated by the expert panel based on the MDS of European Bone Marrow Transplantation (EBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR) registries and the medical records of the transplantation center of Imam Khomeini hospital complex. 399 data items of 1576 were rejected according to the expert's opinion.
Conclusion
In the present study, the validated MDS were developed and will be used in the registry system in the future to record and report the uniform data items of HSCT-related data.