bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tiny Drosophila intestinal stem cells, big power
Authors: Zhai Jingbo , Li Wanyang , Liu Xin , Wang Di , Zhang Dongli , Liu Yanli , Liang Xiuwen , Chen Zeliang 
Published: September 2022

AbstractThe signaling pathways are highly conserved between Drosophila and mammals concerning intestinal development, regeneration, and disease. The powerful genetic tools of Drosophila make it a valuable and convenient alternative to answer basic biological questions that can not be addressed using mammalian models. In this review, we discuss recent advances in how we use fly midgut to answer the following key questions: (1) How intestine stem cell niches are established; (2) which factors control asymmetric division of stem cells; (3) how intestinal cells interact with environmental factors, such as tissue damage, microbiota, and diet; (4) how to screen aging/cancer‐related factors or drugs by fly intestine stem cells.
Increase in marijuana use, binge drinking by young adults
Authors: Knopf Alison 
Published: September 2022

Marijuana use has reached historic highs among young adults ages 19 to 30 years old, with 29% using marijuana in the past 30 days, and 43% using it in the past year; 10.8% used it on a daily or near daily basis (more than 20 days in the past 30 days). The data is based on the Monitoring the Future (MTF) study conducted for the National Institute on Drug Abuse (NIDA). The study uses self‐reports; most recent data is from 2021.
Evaluation of safety and efficacy of the S.M.A.R.T.® Flex Vascular Stent System (OPEN study)
Authors: Gray William A. , Cardenas Joseph , Teigen Corey L. 
Published: September 2022

AbstractObjectivesThe OPEN study evaluated the safety and efficacy of the S.M.A.R.T.® Flex Vascular Stent System in patients with femoropopliteal arterial disease.BackgroundLong‐term data on endovascular treatments of femoropopliteal arterial disease are required to establish the repair durability.MethodsThe OPEN study was a multicenter, single‐arm, prospective study comparing primary safety and efficacy outcomes to performance goals (PG) developed for bare nitinol stents. Patients with symptoms due to a single, ≤180 mm length, de novo femoropopliteal arterial lesion with >70% stenosis were enrolled and followed for 36 months. Subjects with lesions ≤150 mm served as the initial comparison cohort for the PG (other cohorts were analyzed if the PG was met).Results257 subjects with lesions ≤180 mm were enrolled. The mean lesion length was 71 ± 46 mm, and 52.5% had severe claudication. The primary safety endpoint (freedom from all‐cause death, index limb amputation, and target lesion revascularization [TLR] through 30 days) was met in 98.8% (96.5%, 99.6%) of subjects in the comparison cohort, meeting the PG (88.0%). The primary efficacy endpoint (comparison cohort vessel patency at 12 months) was 68.4% (61.1%, 74.8%), where the lower limit of the 95% confidence interval did not meet the 66.0% PG. Freedom from TLR in the per‐protocol cohort at 12‐, 24‐, 36‐month was 84.7%, 74.6%, and 72.8%, respectively. The 24‐month stent fracture rate was 4.3%, with no new fractures identified at 36 months.ConclusionThe results show promising long‐term safety and effectiveness for the S.M.A.R.T.® Flex Vascular Stent System in patients with femoropopliteal arterial disease.
Insights into the Impact of Activators on the ‘Catalytic’ Graphitization to Design Anode Materials for Lithium Ion Batteries
Authors: Hanhart Vanessa , Frankenstein Lars , Ramirez‐Rico Joaquin , Siozios Vassilios , Winter Martin , Gomez‐Martin Aurora , Placke Tobias 
Published: September 2022

AbstractIn this work, we systematically investigate the ‘catalytic’ graphitization of a biomass precursor (coffee ground) using 10–60 wt. % of the activator iron (III) chloride hexahydrate in a temperature range of 1000 °C – 2400 °C. Special focus is put on the correlation of synthesis conditions, e. g., heat treatment temperature and mass fraction of iron chloride, with the electrochemical performance in carbon||Li metal cells. The structural investigations of the materials reveal a positive impact of an increasing heat treatment temperature and/or mass fraction of inserted activator on the degree of graphitization and the delithiation capacity. However, a saturation point regarding the maximum degree of graphitization at 2000 °C and reversible capacity by the ‘catalytic’ graphitization approach using iron (III) chloride has been found. A maximum degree of graphitization of ≈69 % could be reached by applying 2000 °C and 40 wt. % FeCl3 ⋅ 6H2O, resulting in a reversible capacity of 235 mAh g−1.
Introduction of Ferrocene as a Facilitator for the Construction of Supramolecular Polymers
Authors: Umer Lone Mohammad , Sahu Nihar , Kumar Roy Raj , Adhikari Bimalendu 
Published: September 2022

AbstractProper monomer design is the key to enhancing the strength of noncovalent interactions between the molecules toward the efficient formation of supramolecular polymers (SPs). We have designed and synthesized 1,n′‐disubstituted ferrocene‐azobenzene‐long alkyl chains, Fc(CONH‐Azo‐TDP)2, to afford SPs with a high probability. The design exploits the ‘‘molecular ball‐bearing’’ property of the ferrocene core, which allows two azobenzene arms to rotate in the planes of cyclopentadienyl rings, generating the most suitable molecular conformation required for SP formation. This ferrocene monomer formed a supergel consisting of SPs supported by strong intermolecular (H‐bonding and π‐π stacking) interactions and higher enthalpy gain than the reference molecules, where the central ferrocene core was replaced by flexible aliphatic as well as rigid benzene linkers. The molecular conformation involved in SPs, the strength of noncovalent interactions, and the process of supramolecular polymerization were investigated through NMR, UV‐Vis, XRD and TEM studies. The results demonstrate that ferrocene may act as a good modulator for constructing efficient SPs.
Studies on degradation of triphenylmethane dye crystal violet by electro‐flotation device
Authors: Fan Jinjin , Xue Shuwen , Wan Keji , Wang Guoqiang , Miao Zhenyong 
Published: September 2022

AbstractElectrolysis technology is very effective in removing organic pollutants including dye wastewater and takes into account environmental friendliness. This paper deals with the electrochemical degradation of triphenylmethane dye crystal violet (DCV) from the aqueous solution using 304 stainless steel electrodes. The electrolytic cell device with a flotation column structure was set up and the electrolytic degradation process was studied. It could be found that the DCV removal efficiency and reaction rate constants were fitting the first‐order kinetic model. The process performance was analyzed in terms of degradation efficiency and energy consumption. Almost complete degradation (>98%) of 100 mg/L DCV was achieved after the 40 min reaction under the conditions of 300 mg/L NaCl dosage, nature pH (5–7), and 10 V applied voltage. Finally, the behaviours of degradation were studied. In the process of electrochemical degradation, the synergistic effects of electrode electrolysis, including indirect oxidation of electrolyte, hydroxyl radical, flocculation, and air flotation, removed the dye pollutants from the wastewater. The present study has proved the effectiveness and cleanness of electrochemical treatment for the triphenylmethane dye solution.
Robust control of discrete minimum and non‐minimum phase systems via data‐driven virtual reference feedback tuning and IMC
Authors: Suresh Kumar Chiluka , Ambati Seshagiri Rao , Sonawane Shirish H. , Babu Gara Uday Bhaskar 
Published: September 2022

AbstractIn this paper, we develop a novel robust control approach for discrete minimum and non‐minimum phase systems via a combined data‐driven virtual reference feedback tuning () and internal model control (IMC) scheme. The first step in the conventional method controller design is the selection of the closed‐loop reference model (), and selection is still an open problem. The integration of the scheme and the VRFT method provides the advantage of flexibility in controller design due to the incorporation of the filter. As a result, the proposed design method begins with the selection of and filter. Unlike the standard method, the proposed combined and design approach has the unique feature of taking into account a robustness property of dynamics, namely, maximum sensitivity () as the design specification for the and IMC filter selection. Moreover, the proposed approach includes a robustness specification that resolves the trade‐off between performance and robustness in real‐time controller design. Furthermore, the robustness guarantee with plant uncertainties and controller fragility is elucidated. The proposed approach is validated using numerical simulations and experimental validation through the temperature control process. Compared to conventional controllers, experimental and simulation results show that the proposed controllers have less tracking error, minimize control effort, and improve robustness.
Preparation of ferric oxide powders by ultrasonic‐assisted impinging stream reaction
Authors: Zhang Jianwei , Li Kaiqi , Dong Xin , Feng Ying , Ding Changwei 
Published: September 2022

AbstractIn this paper, Fe3O4 powder was prepared by the chemical precipitation method using impinging stream technology. The influences of feed flow rate, L/D, reactant concentration, ratio of iron ion concentration, reaction temperature, and impact time on the size and distribution of particles were investigated by the orthogonal experiment method. The microstructure and morphology of Fe3O4 powders were characterized by scanning electron microscopy, X‐ray diffractometer, and granulometer. The results showed that when ratio of iron ion concentration c(Fe2+):c(Fe3+) = 0.75, reactant concentration c(Fe3+) = 0.4 mol · L−1, feed flow rate Q = 800 L · h−1, L/D = 3, reaction temperature T = 20°C, impact time t = 50 min, the prepared Fe3O4 had an average particle size of 1.815 μm and the most uniform distribution. The influence of ultrasonic enhancement on the mixing process and powder preparation in an impinging stream reactor was investigated. The size and distribution of the powders were significantly affected by ultrasonic enhancement. With the increase in ultrasonic power, the particle size of the powders decreased and the distribution became narrower. The particle size was reduced by 68.78%, and the particle distribution range was narrowed by 84.34% under ultrasound enhancement. This study promised the effective utilization of ultrasonic cavitation in the optimization of experimental equipment and the preparation of ultrafine powder, which provides a basis for process optimization of powder preparation.
Prospective Roles of Scanning Photoelectrochemical Microscopy in Microbial Hybrid Photosynthesis†
Authors: Tian Xiaochun , Bai Rui , Zhao Feng 
Published: September 2022

AbstractMicrobial hybrid photosynthesis has attracted great interests in recent years since it integrates the advantages of natural and artificial photosynthesis for solar‐to‐chemical conversion. Coupling a light source with scanning electrochemical microscopy, scanning photoelectrochemical microscopy (SPECM) shows great potential in investigating the interfacial reactions of microbial hybrid photosynthesis. In this Emerging Topic, the potential roles of SPECM in revealing biotic–abiotic interfacial electron transfer mechanisms and calculating electrode process kinetics are proposed for hybrid photosynthesis, and this will also inspire the applications of SPECM in the fields including biomineralization, photocatalytic‐biodegradation and microbial photoelectrochemical systems.
The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay
Authors: Czerniak Anne Sophie , Kretschmer Kevin , Weiß Tina , Beck‐Sickinger Annette G. 
Published: September 2022

AbstractTo study the binding mode of the adipokine chemerin as well as the short peptide agonist chemerin‐9 (C9) to its two receptors chemokine‐like receptor 1 (CMKLR1) and G protein‐coupled receptor 1 (GPR1), we generated 5‐carboxytetramethylrhodamine (TAMRA) modified variants of both ligands. In addition, we labeled GPR1 and CMKLR1 with a nanoluciferase at the N‐terminus to perform NanoBRET binding assays. For GPR1, both ligands show high affinity and comparable binding. Significant differences were found for CMKLR1, whereby only full‐length chemerin binds with high affinity in saturation and displacement assays. For TAMRA‐C9 a biphasic binding consisting of two binding states has been found and no displacement studies could be performed. Thus, we conclude that CMKLR1 requires full‐length chemerin for stable binding in contrast to GPR1. This work demonstrates the NanoBRET binding assay as a new tool for binding studies at chemerin receptors and it enables deeper insights into the ligand binding parameters.
Blood Components as Carriers for Small‐Molecule Platinum Anticancer Drugs
Authors: Yao Houzong , Zhu Guangyu 
Published: September 2022

AbstractThe efficacy of platinum drugs is limited by severe side effects, drug resistance, and poor pharmacokinetic properties. Utilizing long‐lasting blood components as drug carriers is a promising strategy to improve the circulation half‐lives and tumor accumulation of platinum drugs. Non‐immunogenic blood cells such as erythrocytes and blood proteins such as albumins, which have long lifespans, are suitable for the delivery of platinum drugs. In this concept, we briefly summarize the strategies of applying blood components as promising carriers to deliver small‐molecule platinum drugs for cancer treatment. Examples of platinum drugs that are encapsulated, non‐covalently attached, and covalently bound to erythrocytes and plasma proteins such as albumin and apoferritin are introduced. The potential methods to increase the stability of platinum‐based thiol–maleimide conjugates involved in these delivery systems are also discussed. This concept may enlighten researchers with more ideas on the future development of novel platinum drugs that have excellent pharmacokinetic properties and antitumor performance in vivo.
Conformer‐selective Photodynamics of TrpH+−H2O
Authors: Molina Franco , Dezalay Jordan , Tabata Jun‐ichi , Soorkia Satchin , Broquier Michel , Hirata Keisuke , Ishiuchi Shun‐Ichi , Fujii Masaaki , Grégoire Gilles 
Published: September 2022

AbstractThe photodynamics of protonated tryptophan and its mono hydrated complex TrpH+−H2O has been revisited. A combination of steady‐state IR and UV cryogenic ion spectroscopies with picosecond pump‐probe photodissociation experiments sheds new lights on the deactivation processes of TrpH+ and conformer‐selected TrpH+−H2O complex, supported by quantum chemistry calculations at the DFT and coupled‐cluster levels for the ground and excited states, respectively. TrpH+ excited at the band origin exhibits a transient of less than 100 ps, assigned to the lifetime of the excited state proton transfer (ESPT) structure. The two experimentally observed conformers of TrpH+−H2O have been assigned. A striking result arises from the conformer‐selective photodynamics of TrpH+−H2O, in which a single water molecule inserted in between the ammonium and the indole ring hinders the barrierless ESPT reaction responsible for the ultra‐fast deactivation process observed in the other conformer and in bare TrpH+.
Zeolitic Imidazolate Frameworks Derived Co9S8/Nitrogen‐Doped Hollow Porous Carbon Spheres as Efficient Bifunctional Electrocatalysts for Rechargeable Zinc–Air Batteries
Authors: Liu Ting , Peng Jiayao , Xu Yuting , Huang Jianlin 
Published: September 2022

AbstractThe development of nonprecious metal‐based electrocatalysts with remarkable catalytic activity and long‐cycling lifespan toward oxygen reduction reaction (ORR) and evolution reaction (OER) is especially important for rechargeable zinc–air batteries (ZABs). Herein, monodispersed Co9S8 nanoparticles embedded in nitrogen‐doped hierarchically porous hollow carbon spheres (Co9S8 NPs/NHCS) are synthesized through a template‐assisted strategy followed by a co‐assembly, thermal annealing, and sulfurization process. Benefiting from larger specific surface area, hierarchically porous hollow structure, and carbon nanotubes self‐growth, the obtained Co9S8 NPs/NHCS‐0.5 electrocatalyst exhibits decent performance for ORR (E1/2=0.85 V) and OER (E10=1.55 V). A rechargeable ZAB assembled using the Co9S8 NPs/NHCS‐0.5 as air cathode delivers a maximum power density of 116 mW cm−2, high open circuit voltage of 1.47 V, and good durability (no obvious voltage decay after 1200 cycles (200 hours)). Such a hierarchically porous hollow structure of Co9S8 NPs/NHCS‐0.5 provides a confined space shell and an interconnected hollow core to achieve outstanding bifunctional catalytic activity and cycling stability, which surpass the benchmark Pt/C‐RuO2.
Phosphinine Selenide: Noncovalent Interactions with Organoiodines and Elemental Iodine, and Reactivity towards Potassium Cyanide
Authors: Lin Jinxiong , Coles Nathan T. , Weber Manuela , Müller Christian 
Published: September 2022

AbstractA co‐crystalline adduct consisting of a phosphinine selenide and an organohalide was obtained by slow evaporation of the solvent from a mixture of 2,6‐bis(trimethylsilyl)phosphinine selenide and 1,4‐diiodotetrafluorobenzene (1,4‐TFDIB). The crystallographic characterization of the product shows π‐π stacking, F⋅⋅⋅H hydrogen bonding between 1,4‐TFDIB and the phosphinine selenide, as well as F⋅⋅⋅F interactions between 1,4‐TFDIB molecules. Moreover, the phosphorus heterocycle could be crystallized with diiodine to form a 1 : 1 adduct. The d(I−I) distance in this compound is 2.8475(3) Å, which is shorter than the corresponding one in triphenylphosphine selenide diiodide, reflecting the weaker net‐donor power of the phosphinine selenide towards diiodine. The phosphinine selenide could also be used as a selenium transfer reagent to generate KSeCN from KCN.
Identification of adapted breeding lines to improve barley hybrids for Spain
Authors: Fernández‐Calleja Miriam , Boutin Christophe , Dyrszka Emmanuelle , Manès Yann , Reif Jochen C. , Zhao Yusheng , Aparicio Nieves , Ciudad Francisco J. , Casas Ana M. , Igartua Ernesto 
Published: September 2022

AbstractThis study explores the potential of Spanish germplasm for the development of hybrids adapted to southern Europe, a new region for hybrid barley (Hordeum vulgare). A set of 140 locally adapted, advanced breeding lines, developed in a Spanish public breeding program, were evaluated for their potential to widen the germplasm available for hybrid barley development. A subset of 24 lines was introduced into three‐way hybrid combinations and tested in a field trial network of four locations and 2 yr. The hybrid performance of the rest of the lines was estimated based on genomic prediction models. No three‐way hybrid exceeded the best check. We succeeded in identifying lines with high general combining ability, which could produce promising two‐way hybrids. Some were among those tested in the field, whereas others resulted from genomic predictions, validating the strategy followed of mining locally adapted breeding lines. Rachis brittleness detected in field trials revealed a low but detrimental effect of the presence of alternative brittle mutations in the hybrid combination. The success of hybrid breeding in southern Europe requires further investigation of the underlying heterotic patterns, and appropriate management of brittle genes through prebreeding, to widen the germplasm accessible for hybrid barley breeding.
High Lithium Salt Content PVDF‐Based Solid‐State Composite Polymer Electrolyte Enhanced by h‐BN Nanosheets
Authors: Zhao Yuanjun , Qin Yanyang , Da Xinyu , Weng Xianjun , Gao Yiyang , Gao Guoxin , Su Yaqiong , Ding Shujiang 
Published: September 2022

AbstractDue to the unique safety qualities, solid composite polymer electrolyte (SCPE) has achieved considerable attentions to fabricate high‐energy‐density lithium metal batteries, but its overall performance still has to be improved. Herein, a high lithium salt content poly(vinylidene fluoride) (PVDF)‐based SCPE was developed, enhanced by hexagonal boron nitride (h‐BN) nanosheets, presenting perfect electrochemical performance, fast ion transport, and efficient inhibition of lithium dendrite growth. The optimized SCPE (PVDF‐L70‐B5) could deliver high ionic conductivity (2.98×10−4 S cm−1), ultra‐high Li+ ion transfer number (0.62), wide electrochemical stability window (5.24 V), and strong mechanical strength (3.45 MPa) at room temperature. Density functional theory calculation further confirmed that the presence of h‐BN could promote the dissociation of bis(trifluoromethanesulfonyl)imide lithium (LiTFSI) and the rapid transfer of Li+ ions. As a result, the assembled symmetric Li/Li battery and asymmetric Li/LiFePO4 battery using PVDF‐L70‐B5 SCPEs both exhibited high reversible capacity, long‐term cycle stability, and high‐rate performance when cycled at 60 or 30 °C. The designed SCPEs will open up a new route to synthesize solid‐state lithium batteries with high energy density and high safety.
PBRM1 presents a potential prognostic marker and therapeutic target in duodenal papillary carcinoma
Authors: He Xujun , Xu Ji , Niu Nan , Xu Guoxi , Zhu Honglin , Liu Zhengchuang , Mou Yiping , Qian Zhengyuan , Wang Huiju , Hu Junfeng , Ma Tonghui , Ma Jie , Tao Houquan 
Published: September 2022

AbstractBackgroundDue to its rarity, duodenal papillary carcinoma (DPC) is seldom studied as a unique disease and no specific molecular features or treatment guidelines are provided.MethodsWhole‐exome sequencing was performed to gain new insights into the DPC mutation landscape and to identify potential signalling pathways and therapeutic targets. Mechanistically, immunohistochemistry (IHC), immunofluorescence, RNA‐seq, ATAC‐seq and in vitro cell function experiments were performed to confirm the underlying mechanisms.ResultsWe described the mutational landscape of DPC for the first time as a group of rare tumours with a high frequency of dysregulation in the chromatin remodelling pathway, particularly PBRM1‐inactivating mutations that are significantly higher than duodenal adenocarcinomas and ampullary adenocarcinoma (27% vs. 0% vs. 7%, p < .01). In vitro cell experiments showed that downregulation of PBRM1 expression could significantly promote the cancer progression and epithelial‐to‐mesenchymal transition via the PBRM1‐c‐JUN‐VIM axis. The IHC data indicated that PBRM1 deficiency (p = .047) and c‐JUN expression (p < .001) were significantly associated with poor prognosis. Meanwhile, the downregulation of PBRM1 expression in HUTU‐80 cells was sensitive to radiation, which may be due to the suppression of c‐JUN by irradiation.ConclusionsOur findings define a novel molecular subgroup of PBRM1‐inactivating mutations in DPC. PBRM1 play an important role in DPC progression and may serve as a potential therapeutic target and prognostic indicator.