bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?
Authors: Zeltz Cédric , Navab Roya , Heljasvaara Ritva , Kusche-Gullberg Marion , Lu Ning , Tsao Ming-Sound , Gullberg Donald 
Published: April 2022

AbstractThere is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (CAFs) will need to be carefully re-evaluated. Fibroblast-derived cells are not only in the focus in tumors, but also in tissue fibrosis as well as in inflammatory conditions. The recent transcriptional profiling of what has been called “the pan-fibroblast cell lineage” in mouse and human tissues has identified novel transcriptional biomarker mRNAs encoding the secreted ECM proteins dermatopontin and collagen XV as well as the phosphatidylinositol-anchored membrane protein Pi16. Some of the genes identified in these fibroblasts scRNA-seq datasets will be useful for rigorous comparative characterizations of fibroblast-derived cell subpopulations. At the same time, it will be a challenge in the coming years to validate these transcriptional mRNA datasets at the protein-(expression) and at tissue-(distribution) levels and to find useful protein biomarker reagents that will facilitate fibroblast profiling at the cell level. In the current review we will focus on the role of the collagen-binding integrin α11β1 in CAFs, summarizing our own work as well as published datasets with information on α11 mRNA expression in selected tumors. Our experimental data suggest that α11β1 is more than just another biomarker and that it as a functional collagen receptor in the TME is playing a central role in regulating collagen assembly and matrix remodeling, which in turn impact tumor growth and metastasis.
Characterizing groundwater salinity patterns in a coastal sand aquifer at Magilligan, Northern Ireland, using geophysical and geotechnical methods
Authors: Águila Jesús F. , McDonnell Mark C. , Flynn Raymond , Hamill Gerard A. , Ruffell Alastair , Benner Eric M. , Etsias Georgios , Donohue Shane 
Published: April 2022

AbstractTidal forcing influences groundwater flow and salt distribution in shallow coastal aquifers, with the interaction between sea level variations and geology proving fundamental for assessing the risk of seawater intrusion (SI). Constraining the relative importance of each is often confounded by the influences of groundwater abstraction and geological heterogeneity, with understanding of the latter often restricted by sampling point availability and poor spatial resolution. This paper describes the application of geophysical and geotechnical methods to better characterize groundwater salinity patterns in a tidally dominated ~ 20 m thick sequence of beach sand, unaffected by groundwater abstraction. Electrical resistivity tomography (ERT) revealed the deposit to consist of an upper wedge of low resistivity (< 3 Ωm), reaching over 8 m thick in the vicinity of the low water mark, overlying a higher resistivity unit. Cone penetrometer testing (CPT), and associated high-resolution hydraulic profiling tool system (HPT), coupled with water quality sampling, revealed the wedge to reflect an intertidal recirculation cell (IRC), which restricts freshwater discharge from a relatively homogeneous sand unit to a zone of seepage within the IRC. The application of CPT and HPT techniques underscored the value of geotechnical methods in distinguishing between geological and water quality contributions to geophysical responses. Survey results have permitted a clear characterization of the groundwater flow regime in a coastal aquifer with an IRC, highlighting the benefit of combining geophysical and geotechnical methods to better characterize shallow SI mechanisms and groundwater flow in coastal hydrogeological environments.
Training in Mindfulness or Loving-kindness Meditation Is Associated with Lower Variability in Social Connectedness Across Time
Authors: Don Brian P. , Van Cappellen Patty , Fredrickson Barbara L. 
Published: April 2022

Abstract
Objectives
Research demonstrates that meditation interventions tend to positively influence social well-being. Yet, prior research has exclusively examined meditation in relation to average levels of social outcomes (e.g., social connectedness), despite other work demonstrating variability or fluctuations in social functioning play a distinct role in contributing to well-being. This study examined the hypothesis that training in mindfulness meditation and loving-kindness meditation would predict lower variability in social connectedness, even accounting for their positive influence on average levels of social connectedness. Moreover, this study also examined the hypothesis that lower variability in positive and negative emotions would mediate the link between training in meditation and reduced variability in social connectedness.

Methods
These hypotheses were tested using a randomized study of 224 mid-life adults. Participants received training in either mindfulness or loving-kindness meditation for 6 weeks. They reported their daily social connectedness and emotions for 2 weeks prior to the training, 6 weeks during the training, and 3 weeks after the training.

Results
Consistent with hypotheses, results demonstrated that participants in both meditation groups reported lower variability in social connectedness across the course of the intervention, even accounting for average levels of connectedness. Moreover, lower positive and negative affective variability partially mediated the association between time (training in meditation) and reduced variability in social connectedness.

Conclusions
These results suggest that (a) meditation may help to smooth social ups and downs across time and that (b) it may do so via its association with reduced affective variability.
Land suitability assessment for surface irrigation development at Ethiopian highlands using geospatial technology
Authors: Hagos Yonas Gebresilasie , Mengie Mequanent Abathun , Andualem Tesfa Gebrie , Yibeltal Mesenbet , Linh Nguyen Thi Thuy , Tenagashaw Diress Yigezu , Hewa Guna 
Published: April 2022

AbstractIrrigation development necessitates suitable lands for higher yield production and the development of long-term irrigation systems. The purpose of this research was to identify appropriate irrigation lands for irrigation in the Minch Yekest watershed in West Amhara, Ethiopia. Geospatial and multi-criteria decision-making techniques were used in this study. For land suitability analysis for surface irrigation, slope, land use, altitude, distance from the water source, soil characteristics, and available water storage capacity parameters were used. To find the best location for surface irrigation, the values were weighted and combined using the weighted overlay tool. The irrigation land suitability of each physical land parameter was classified into four suitability classes (S1, S2, S3, and N) based on the Food and Agricultural Organization guideline. According to the findings, 63% of the watershed area is highly suitable, 6.25% is moderately suitable, 28.69% is marginally suitable, and 2.06% is not suitable for the aforementioned purposes. The methodological approach and study findings could help policymakers make better decisions when developing irrigation projects in Ethiopia.
Modeling stage–discharge–sediment using support vector machine and artificial neural network coupled with wavelet transform
Authors: Kumar Manish , Kumar Pravendra , Kumar Anil , Elbeltagi Ahmed , Kuriqi Alban 
Published: April 2022

AbstractMany real water issues involve rivers’ sediment load or the load that rivers can bring without degrading the fluvial ecosystem. Therefore, the assessment of sediments carried by a river is also crucial in the planning and designing of various water resource projects. In the current study, five different data-driven techniques, namely artificial neural network (ANN), wavelet-based artificial neural network (WANN), support vector machine (SVM), wavelet-based support vector machine (WSVM), and multiple-linear regression (MLR) techniques, were employed for time-series modeling of daily suspended sediment concentration (SSC). Hydrological datasets containing the daily stage (h), discharge (Q), and SSC for 10 years (2004–2013) from June to October at Adityapur and Ghatshila station of Subernrekha river basin, Jharkhand, India, were considered for analysis. The Gamma test was used to determine the input variables in the first step. Various combinations were made by lagging the maximum three-day time step for predicting current-day SSC. The outcomes of ANN, SVM, WAAN, WSVM, and MLR models were evaluated with the actual values of SSC based on statistical metrics. Pearson correlation coefficient (PCC), root-mean-square error (RMSE), Nash–Sutcliffe efficiency (NSE), and Wilmot index (WI) as well as visual inspection of time variation, scatter plots, and Taylor diagrams. Our results stated that the WSVM model discovered the best trustworthy models among all existing models. PCC, RMSE, NSE, and WI values were 0.844 and 0.781, 0.096 g/l and 0.057 g/l, 0.711 and 0.591, 0.907 and 0.878, respectively, throughout the training and testing processes at the Adityapur site. Also, at the Ghatshila location, it was the most accurate model. During the training and testing stages, PCC, RMSE, NSE, and WI values were 0.928 and 0.751, 0.117 g/l and 0.095 g/l, 0.861 and 0.541, 0.962 and 0.859, respectively. Our findings showed that the WANN model was the second-best model during the testing phase for both sites. Hence, the WSVM technique can model SSC at this location and other similar (i.e., geomorphology and flow regime type) rivers.
Synthesis of magnetic Fe3O4/activated carbon prepared from banana peel (BPAC@Fe3O4) and salvia seed (SSAC@Fe3O4) and applications in the adsorption of Basic Blue 41 textile dye from aqueous solutions
Authors: Mohammadifard Aynaz , Allouss Dalia , Vosoughi Mehdi , Dargahi Abdollah , Moharrami Amir 
Published: April 2022

AbstractTextile industries use large amounts of water and chemicals for finishing and dying processes. The chemical structures of dyes vary enormously, and some have complicated aromatic structures that resist degradation in conventional wastewater treatment processes because of their stability to sunlight, oxidizing agents, and microorganisms. The objective of this research is to compare the adsorption efficiency of two types of magnetic activated carbons derived from Banana peel and Salvia seed for the removal of basic blue 41 dye. The faculty of the produced activated carbons to remove basic blue 41 dye from aqueous solutions via batch adsorption has been examined under several operating conditions such as pH, adsorbent dose, initial adsorbate concentration and contact time. The cheap, non-toxic produced activated carbons (AC) were characterized by scanning electron microscope and Brunauer-Emmett-Teller analyses. The best conditions of dye adsorption with BPAC@ Fe3O4 equal to pH = 9, AC dose 0.5 g/L , dye concentration 50 mg/L and equilibrium contact time 30 min, optimal dye adsorption conditions for SSAC@Fe3O4 equal to pH = 9, adsorbent dose 0.75 mg/L , dye concentration 50 mg/L and equilibrium contact time is 30 min. This study followed the Langmuir isotherm model well with regression coefficient of R2= 0.9886 for BPAC@Fe3O4 and regression coefficient of R2= 0.9764 for SSAC@Fe3O4.
Analysis of the structural characteristics and spatial organization of macrobenthic fauna in Oualidia lagoon, Morocco
Authors: El Asri Fatima , Errhif Ahmed , Tamsouri Mohamed-Naoufal , Martin Daniel , Maanan Mohamed , Zidane Hakima 
Published: April 2022

AbstractMorocco is a very rich country in terms of wetlands, including bays, estuaries, lagoons, lakes, and rivers, among others. However, many of them need to be well managed and better exploited, thus requiring baseline descriptive studies to assess faunal patterns and trends. Oualidia lagoon is not an exception. In fact, the studies conducted to date in the lagoon mainly focused on its oceanographic features and aquaculture capacities. The present paper presents the first study on the whole macrofaunal assemblages of Oualidia lagoon, having as main objectives analyze the composition and structure of the assemblages, as well as their relationships with the main environmental variables explaining their spatial distribution variability in the enclosed ecosystem of the Oualidia coastal lagoon. The benthic macroinvertebrates of Oualidia lagoon were studied in summer 2013 based on 43 stations spread over the whole lagoon by using a Van Veen grab. Two replicate samples were collected for macrobenthos and one additional replicate for sediment analyses at each station. Also, single water salinity and temperature measurements were recorded at each station. Fifty-one species from seven different taxa were recorded, among which mollusks (37%), polychaetes (25%) and crustaceans (25%) dominated in terms of species number. Peringia ulvae, Abra alba, Sphaeroma serratum, Cerastoderma edule and Corophium sp. accounted for 88% of total abundance. The benthos was structured along a downstream–upstream gradient, showing three assemblages, named according to the IndVal index: (1) Diopatra cf. marocensis, (2) Peringia ulvae, and (3) Cerastoderma edule, while the main factors driving their distribution were granulometry and salinity. The Biotic and Environmental analysis showed that the combination of granulometry and salinity was the major factors controlling the spatial distribution of the macrozoobenthos in the Oualidia Lagoon.
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques
Authors: Gao Chun-Chun , Li Man , Deng Wei , Ma Chun-Hui , Chen Yu-Sheng , Sun Yong-Qiao , Du Tingfu , Liu Qian-Lan , Li Wen-Jie , Zhang Bing , Sun Lihong , Liu Si-Meng , Li Fengli , Qi Feifei , Qu Yajin , Ge Xinyang , Liu Jiangning , Wang Peng , Niu Yamei , Liang Zhiyong , Zhao Yong-Liang , Huang Bo , Peng Xiao-Zhong , Yang Ying , Qin Chuan , Tong Wei-Min , Yang Yun-Gui 
Published: April 2022

AbstractSARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlying mechanism, in particular immune responses in different organs, remains elusive. In this study, comprehensive transcriptomic alterations of 14 tissues from rhesus macaque infected with SARS-CoV-2 were analyzed. Compared to normal controls, SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs, with drastic transcriptomic changes in cerebral cortex and right ventricle. Intriguingly, cerebral cortex exhibited a hyperinflammatory state evidenced by significant upregulation of inflammation response-related genes. Meanwhile, expressions of coagulation, angiogenesis and fibrosis factors were also up-regulated in cerebral cortex. Based on our findings, neuropilin 1 (NRP1), a receptor of SARS-CoV-2, was significantly elevated in cerebral cortex post infection, accompanied by active immune response releasing inflammatory factors and signal transmission among tissues, which enhanced infection of the central nervous system (CNS) in a positive feedback way, leading to viral encephalitis. Overall, our study depicts a multi-tissue/organ transcriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2, and provides important insights into the mechanistic basis for COVID-19-associated clinical complications.
Transfer in der berufsbezogenen Weiterbildung: Systematisches Literaturreview und Synthese mit Blick auf die Handlungsmöglichkeiten der Lehrenden
Authors: Wißhak Susanne 
Published: April 2022

ZusammenfassungIn der berufsbezogenen Weiterbildung gilt der Transfer des Gelernten als zentrales, wenngleich schwer erreichbares Erfolgskriterium. Das systematische Literaturreview folgt der Prämisse, dass Transfer gezielt gefördert werden muss und dass die Rolle der Lehrenden dabei bisher unzureichend berücksichtigt wurde. Mit dem Ziel, die empirische Forschungslage zu Transferdeterminanten zu analysieren, wurden 19 Metaanalysen aus dem Zeitraum zwischen 1988 und 2021 ausgewertet. Die Ergebnisse wurden zusammengefasst und mit Blick auf mögliche Ansatzpunkte der Transferförderung durch die Lehrenden interpretiert. Erwartungsgemäß scheint der Handlungsspielraum der Lehrenden hinsichtlich des Weiterbildungsdesigns am größten. Abhängig von den Weiterbildungszielen erwiesen sich unterschiedliche Lehr-Lern-Methoden und -Prinzipien als transferförderlich. Daneben können Lehrende aber auch auf einzelne Teilnehmendenmerkmale, wie die Motivation und Selbstwirksamkeit, Einfluss nehmen. Die Transferförderung im Arbeitsumfeld können sie begünstigen, indem sie diese rechtzeitig anbahnen, wichtige Beteiligte einbinden und über die Weiterbildungsmaßnahme hinaus Unterstützung anbieten. Das Literaturreview kommt zu dem Schluss, dass Lehrende Transfer fördern können und die dafür nötigen Kompetenzen besitzen sollten.
Electron thermodynamics along magnetic nozzle lines in a helicon plasma
Authors: Vinci Alfio E. , Delavière–Delion Quentin , Mazouffre Stéphane 
Published: April 2022

AbstractThe electron cooling rate is experimentally investigated along the magnetic lines of a helicon plasma device operating with different magnetic nozzle shapes. Probe measurements in a 2-D region of the plasma plume outline that the polytropic index of electrons has dissimilar values along distinct streamlines ranging from γe≃1.4 to γe>1.8. Accounting for ionization phenomena as an additional degree of freedom allows to predict a polytropic index smaller than the adiabatic limit. It is observed that a reduced cross-field transport can effectively reduce the electrons degrees of freedom.
Gromov–Witten theory and Noether–Lefschetz theory for holomorphic-symplectic varieties
Authors: Oberdieck Georg 
Published: April 2022

Abstract
We use Noether–Lefschetz theory to study the reduced Gromov–Witten invariants of a holomorphic-symplectic variety of

$K3^{[n]}$

-type. This yields strong evidence for a new conjectural formula that expresses Gromov–Witten invariants of this geometry for arbitrary classes in terms of primitive classes. The formula generalizes an earlier conjecture by Pandharipande and the author for K3 surfaces. Using Gromov–Witten techniques, we also determine the generating series of Noether–Lefschetz numbers of a general pencil of Debarre–Voisin varieties. This reproves and extends a result of Debarre, Han, O’Grady and Voisin on Hassett–Looijenga–Shah (HLS) divisors on the moduli space of Debarre–Voisin fourfolds.
Web-based dietary assessment and advice helps inflammatory bowel disease patients to improve their diet quality
Authors: Lamers Carlijn R. , van Erp Liselot W. , Slotegraaf Anne I. , Groenen Marcel J. M. , de Roos Nicole M. , Wahab Peter J. , Witteman Ben J. M. 
Published: April 2022

AbstractTime to evaluate diet quality and give dietary advice is limited in clinical inflammatory bowel disease (IBD) practice. The Eetscore is a web-based tool that assesses diet quality according to the Dutch dietary guidelines and provides personalised dietary advice. We aimed to assess diet quality of IBD patients using the Eetscore and to study changes in diet quality, health-related quality of life (HRQoL) and clinical disease activity over time. A prospective cohort study was performed in 195 adult IBD patients. Participants were invited to fill out questionnaires (Eetscore-FFQ, short Inflammatory Bowel Disease Questionnaire and Patient Harvey Bradshaw Index/Patient Simple Clinical Colitis Activity Index) at baseline and after 1 and 4 months. The Eetscore calculates diet quality based on sixteen food components (ten points per component, total score 0–160; the higher the better) and provides dietary advice per component based on the assessment. At baseline, mean diet quality was 98 (sd 19). Diet quality was positively associated with age, female sex and level of education. Component scores were highest for red meat, wholegrain products and sweetened beverages, and lowest for legumes, nuts and processed meat. Over time, diet quality increased to 107 (sd 21) at 4 months (P < 0·001). Each ten-point improvement in diet quality was associated with an increase in HRQoL (β = 0·4 (95 % CI (0·02, 0·7), P = 0·04). Clinical disease activity did not change. In conclusion, diet quality of IBD patients significantly improved following personalised dietary advice of the Eetscore. Improvement of diet quality was associated with a slight improvement in HRQoL. The Eetscore is a practical and useful tool to monitor and support a healthy diet in IBD patients.
INSIDE OUT
Authors: Fraser Juliet 
Published: April 2022

AbstractThis text was written in response to a commission from Berliner Festspiele/MaerzMusik – Festival for Time Issues 2021. Juliet Fraser collaborated with filmmaker Jessie Rodger to create an experimental video essay that layered raw footage of Juliet in her erstwhile London studio space, reading her own words, reflecting on the words of others and doing her singing practice. The result offered a glimpse into one artist's efforts to remain creative and connected during the time of Covid. What follows is the written essay; the full video essay, Inside Out, can be seen at www.youtube.com/watch?v=m96xf41-_PA.
Variation in hospital costs and resource utilisation after congenital heart surgery
Authors: Blinder Joshua J. , Huang Yuan-Shung , Rossano Joseph W. , Costarino Andrew T , Li Yimei 
Published: April 2022

AbstractBackground:Children undergoing cardiac surgery have overall improving survival, though they consume substantial resources. Nationwide inpatient cost estimates and costs at longitudinal follow-up are lacking.Methods:Retrospective cohort study of children <19 years of age admitted to Pediatric Health Information System administrative database with an International Classification of Diseases diagnosis code undergoing cardiac surgery. Patients were grouped into neonates (≤30 days of age), infants (31–365 days of age), and children (>1 year) at index procedure. Primary and secondary outcomes included hospital stay and hospital costs at index surgical admission and 1- and 5-year follow-up.Results:Of the 99,670 cohort patients, neonates comprised 27% and had the highest total hospital costs, though daily hospital costs were lower. Mortality declined (5.6% in 2004 versus 2.5% in 2015, p < 0.0001) while inpatient costs rose (5% increase/year, p < 0.0001). Neonates had greater index diagnosis complexity, greater inpatient costs, required the greatest ICU resources, pharmacotherapy, and respiratory therapy. We found no relationship between hospital surgical volume, mortality, and hospital costs. Neonates had higher cumulative hospital costs at 1- and 5-year follow-up compared to infants and children.Conclusions:Inpatient hospital costs rose during the study period, driven primarily by longer stay. Neonates had greater complexity index diagnosis, required greater hospital resources, and have higher hospital costs at 1 and 5 years compared to older children. Surgical volume and in-hospital mortality were not associated with costs. Further analyses comprising merged clinical and administrative data are necessary to identify longer stay and cost drivers after paediatric cardiac surgery.