bluuebunny/crossref_metadata_2025_split huggingface dataset:
Movement Difficulties at Age Five Among Extremely Preterm Infants
Authors: Aubert Adrien M. , Costa Raquel , Ådén Ulrika , Cuttini Marina , Männamaa Mairi , Pierrat Véronique , Sarrechia Iemke , van Heijst Arno F. , Zemlin Michael , Johnson Samantha , Zeitlin Jennifer ,   the SHIPS Research group
Published: May 2022

BACKGROUND AND OBJECTIVES
Children born extremely preterm (EPT), &lt;28 weeks’ gestational age, face higher risks of movement difficulties than their term-born peers. Studies report varying prevalence estimates and prognostic factors identifying children who could benefit from early intervention are inconsistent. This study investigated the prevalence of movement difficulties in children born EPT and associated risk factors.

METHODS
Data come from a population-based EPT birth cohort in 2011 and 2012 in 11 European countries. Children without cerebral palsy were assessed at 5 years of age (N = 772) with the Movement Assessment Battery for Children–Second Edition, which classifies movement difficulties as none (&gt;15th percentile), at risk (6th–15th percentile) and significant (≤5th percentile). Associations with sociodemographic, perinatal, and neonatal characteristics collected from obstetric and neonatal medical records and parental questionnaires were estimated using multinomial logistic regression.

RESULTS
We found 23.2% (n = 179) of children were at risk for movement difficulties and 31.7% (n = 244) had significant movement difficulties. Lower gestational age, severe brain lesions, and receipt of postnatal corticosteroids were associated with significant movement difficulties, whereas male sex and bronchopulmonary dysplasia were associated with being at risk and having significant movement difficulties. Children with younger, primiparous, less educated, and non-European-born mothers were more likely to have significant movement difficulties. Differences in prevalence between countries remained after population case-mix adjustments.

CONCLUSIONS
This study confirms a high prevalence of movement difficulties among EPT children without cerebral palsy, which are associated with perinatal and neonatal risk factors as well as sociodemographic characteristics and country.
Seasonal variation of cladocera in a perennial pond, Ambajogai (Maharashtra), India
Authors: Sakhare Vishwas Balasaheb , Chalak Ashwini Dnyandeo 
Published: May 2022

A systematic investigation on seasonal variations of cladocera in Udayan Sarovar, a perennial pond near Swami Ramanand Teerth Mahavidyalaya at Ambajogai (Maharashtra, India) was carried out for a period of one year from June 2018 to May 2019. A total of 9 species of cladocera were identified. The cladoceran diversity fluctuated seasonally and the maximum number of 240 organisms L–1 was recorded during month of April and minimum number of 22 organisms L–1 during the month of September.
Use of artificial substrate in pond culture of freshwater prawn (Macrobrachium rosenbergii): a new approach regarding growth performance and economic return
Authors: Tuly Dilshad Milky , Islam Md. Sherazul , Hasnahena Mst. , Hasan Md. Rezwanul , Hasan Md. Tawhid 
Published: May 2022

An experiment was conducted for six months to evaluate the effects of artificial substrates on the survival, growth and production of Macrobrachium rosenbergii juveniles. The T1 contained locally available bamboo-made substrate both vertical and horizontal and T2 received no substrate. Juvenile prawns (0.40±0.13 g) were stocked at the rate of 19,760 prawns ha-1. The water quality parameters range such as temperature, pH and DO were 22.06-33.45°C, 7.70-8.40 and 4.75-6.15 mgl-1 respectively which was no significant difference (P<0.05) between two treatments. The final weight was 56.48±6.56 g and 45.03±2.11 g in T1 and T2 respectively. The survival rate of T1 was 63.12% which was significantly higher (P>0.05) than T2 (56.87%). The specific growth rate, food conversion ratio and protein efficiency ratio were 1.19 % and 1.14 %, 3.15 and 4.39, 0.98 and 0.71 in T1 and T2 respectively which were not significantly different (P<0.05) between treatments. The total production and net profit in T1 was 1408 kgha-1 and BDT 117,325 ha-1 which was significantly higher (P>0.05) than T2. Thus growth and survival of prawn juveniles improved in presence of artificial substrate which could be economically viable technique for the freshwater prawn culture.
O Parque do Flamengo enquanto Patrimônio: Os desafios da peculiaridade estética do jardim pelo valor da historicidade
Authors: Lontra Nacif Cristina , Oliveira Gonzalez Lopez Thiago 
Published: May 2022

Entre as demandas de proteção frente ao ameaçador movimento de mercado e a necessidade de garantia do elo com a paisagem, as considerações do filósofo Georg Lukács definem uma leitura na qual, mesmo que submetidas a estruturas qualitativamente distintas, ambas esferas de abordagem se comunicam intrinsecamente. Isto porque, consolidadas as apreensões da peculiaridade do jardim e as determinações históricas do objeto, supera-se a descrição dos fatos ocorridos e, com isso, o Parque do Flamengo pode ser visto à luz da consciência humana que o permitiu. Por fim, o conteúdo afirmativo do jardim, ao mesmo tempo que limita a abertura crítica do espaço e o difere das demais artes, termina por apresentar um registro histórico que é capaz de apresentar as questões principais de um determinado aqui e agora. À luz da dimensão patrimonial, portanto, o jardim se converte em importante registro urbano a receber proteção, bem como o Parque do Flamengo aborda elementos precisos com o seu entorno a partir de sua dimensão estética.
Mudanças no uso do solo (2008 - 2018) na Avenida Prefeito Roque Vernalha, Paranaguá, Paraná
Authors: Furuzawa Marcos , Pires Christian , Luis Tonetti Emerson 
Published: May 2022

Monitorar as mudanças no uso do solo urbano é uma forma de evitar alterações na qualidade do ambiente que podem ser prejudiciais ao bem estar humano. O presente trabalho de pesquisa teve o objetivo de analisar as mudanças dos usos ao longo da Avenida Prefeito Roque Vernalha na área urbana do município de Paranaguá na região costeira do Paraná, nos anos de 2008 e 2018. Para isso, diante de cada lote, foi realizada a reclassificação em 2018, a partir do levantamento realizado em 2008, dos usos: espaços de uso público e livres de edificações, residencial, terreno baldio, menor potencial de causar poluição, maior potencial de causar poluição. As três classes iniciais foram consideradas pontos de referência para a boa qualidade ambiental e por isso, apenas os lotes com usos comerciais e industrial/portuário receberam potencialidade de poluição. Após a coleta, os dados foram inseridos em uma planilha para a comparação da variação dos usos. Os resultados mostraram que não houve modificação no número de lotes. Ocorreu aumento de 13,3% das classes de usos com menor e maior potencial de causar poluição e igual redução no conjunto das demais classes. A análise temporal da paisagem estudada, indica potencial mudança na qualidade do ambiente. Tal resultado, pode contribuir para propostas futuras de gestão no município, considerando a sinergia de usos inadequados e incompatíveis com o residencial e com os espaços de uso público e livres de edificações.

Palavras-chave: Uso do solo. Qualidade ambiental. Planejamento da paisagem urbana.
Burnout en cuidadores formales e informales del adulto mayor. revisión integrativa de la literatura
Authors: Bedoya Buritica Natalia , Buitrago Lilia Andrea , Soto Chaquir Mercy 
Published: May 2022

El cuidador del adulto mayor formal e informal, es susceptible de presentar sindrome de burnout “estar quemado, consumido, apagado” como respuesta al estrés después de un tiempo de trabajo.
Objetivo: evaluar según la literatura las características y los factores asociados al síndrome de burnout en cuidadores formales e informales del adulto mayor.
Metodología: se realizó una revisión bibliográfica integrativa para sintetizar los resultados de investigaciones anteriores, y recoger las conclusiones de la literatura sobre las características y factores asociados al burnout en cuidadores formales e informales.
Resultados: se encontró que predomina en un 80.3% el género femenino en los cuidadores formales e informales, la edad promedio oscila entre los 35 a 58 años . Los factores que generan mayor presencia del burnout son el tiempo diario dedicado al cuidado, la carencia de apoyo familiar y la falta de remuneración para el caso de los cuidadores informales.
Conclusiones: en los cuidadores formales e informales el burnout se presenta en algún momento de su vida con manifestaciones físicas y emocionales similares, afectando con más altos niveles a los cuidadores informales, lo cuál está relacionado con la ausencia de remuneración económica, tener a cargo otras labores como ser ama de casa, ser hijas o esposas de la persona receptora del cuidado y un bajo nivel de escolaridad, las principales manifestaciones son: ira, frustración, periodos de insomnio, irritabilidad, ansiedad y depresión.
Se requieren programas de apoyo con estrategias de afrontamiento adaptativas para la prevención del burnout.
Formación doctoral en práctica y filosofía de la ciencia de enfermería: dos vías para trascender la utopía de una práctica docta: ensayo
Authors: Vergara Escobar Oscar Javier , Castañeda Valencia Cándida Rosa 
Published: May 2022

La Educación en enfermería avanzada ha revolucionado las ciencias y las tendencias de acuerdo con el ritmo del mundo indica, que el epicentro de formación en investigación está en la práctica del cuidado.
Objetivo: reflexionar sobre la formación Doctoral en enfermería desde los doctorados para la práctica y los doctorados en Filosofía y sus potencialidades en el contexto colombiano.
Metodología: se desarrolla un ensayo reflexivo que busca mostrar posturas entre la formación doctoral en enfermería y su pertinencia en el contexto colombiano.
Conclusiones: Se requieren de estos dos tipos de doctorados, puesto que serán el camino por recorrer desde la Ciencia de Enfermería, que invita a que los doctorados a propiciar un trabajo con apoyo mutuo y juntos que permita trabajar en red y avanzar en la creación y traducción de conocimientos en la práctica y la investigación en el contexto colombiano.
Embelin enhances the sensitivity of renal cancer cells to axitinib by inhibiting HIF signaling pathway
Authors: Fang Qiong , Li Zhiying , Xue Ye , Zong Xin , Ma Wenshuang , Xi Guangmin , Zhang XiaoFeng , Li Zuowei 
Published: May 2022

Abstract
Background: Renal cell carcinoma (RCC) is a common malignant tumor of urinary system with high recurrence rate and easy metastasis. Current clinical drugs for renal cell carcinoma include immunotherapy and targeted drugs. Axitinib is a clinical targeted drug for the treatment of renal cell carcinoma, which has some shortcomings such as unstable efficacy and easy drug resistance. The aim of this study was to determine whether embelin can enhance the sensitivity of renal cancer cells to axitinib and explore its regulatory pathways. Results: Embelin enhanced the sensitivity of renal cancer cells to axitinib in the following aspects: enhancing the inhibition of cell proliferation by axitinib, and the induction of cell apoptosis. HIF was a potential pathway of Embelin action. After IOX2 regulated the HIF-1α pathway, the enhancing effect of embelin on axitinib was weakened. Moreover, after PT2977 regulated the HIF-2α pathway, the enhancing effect of embelin on axitinib was also weakened.Conclusions: Embelin enhanced the sensitivity of both A498 and 786-O renal cancer cells to axitinib by inhibiting the HIF pathway.
Low-intensity pulsed ultrasound promotes cell viability and inhibits apoptosis of H9C2 cardiomyocytes in 3D bioprinting scaffolds via PI3K-Akt and ERK1/2 pathways
Authors: Hu Yugang , Jia Yan , Wang Hao , Cao Quan , Yang Yuanting , Zhou Yanxiang , Tan Tuantuan , Huang Xin , Zhou Qing 
Published: May 2022

Abstract
Objective: The aim of this study was to investigate whether low-intensity pulsed ultrasound (LIPUS) promotes myocardial cell viability in three-dimensional (3D) cell-laden gelatin methacryloyl (GelMA) scaffolds. Methods: Cardiomyoblasts (H9C2s) were mixed in 6% (w/v) GelMA bio-inks and printed using extrusion-based 3D bioprinter. These scaffolds were exposed to LIPUS with different parameters or sham-irradiated to optimize the LIPUS treatment. The viability of H9C2s was measured using Cell Counting Kit-8 (CCK8), cell cycle, and live and dead cell double staining assays. Western blot analysis was performed to determine the protein expression levels. Results: We successfully fabricated 3D bio-printed cell-laden GelMA scaffolds. CCK8 and live and dead cell double-staining assays indicated that the optimal conditions for LIPUS were a frequency of 0.5 MHz and exposure time of 10 min. Cell cycle analysis showed that LIPUS promoted the entry of cells into the S and G2/M phases from the G0/G1 phase. Western blot analysis revealed that LIPUS promoted the phosphorylation and activation of ERK1/2 and PI3K-Akt. The ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt, respectively, which in turn reduced the LIPUS-induced viability of H9C2s in 3D bio-printed cell-laden GelMA scaffolds. Conclusion: A frequency of 0.5 MHz and exposure time of 10 min for LIPUS exposure can be adapted to achieve optimized culture effects on myocardial cells in 3D bio-printed cell-laden GelMA scaffolds via the ERK1/2 and PI3K-Akt signaling pathways.
Computational Wear of Knee Implant PolyEthylene Insert Surface under Continuous Dynamic Loading and Posterior Tibial Slope Variation Based on Cadaver Experiments with Comparative Verification
Authors: OZER Alaettin 
Published: May 2022

Abstract
BackgroundThe effect of posterior tibial slope on the maximum contact pressure and wear volume of PE insert were not given special attention. The effects of flexion angle, AP Translation and Tibial slope on the max contact pressure and wear of PE insert of TKR were investigated under loadings which were obtained in cadaver experiments by using Archard’s wear law. This study uses not only loads obtained from cadaver experiments but also dynamic flexion starting from 0 to 90 degree.MethodWear on knee implant polyethylene (PE) insert was investigated using a 2.5 size 3D knee model and Finite Element Method (FEM) under loadings and Anterior-Posterior (AP) Translation data ranging from 0 to 90 flexion angles validated by cadaver experiments. Two types of analyses were done to measure the wear effect on knee implant PE insert. The first set of analyses included the flexion angles dynamically changing with the knee rotating from 0 to 90 angles according to femur axis and the transient analyses for loadings changing with a certain angle and duration.ResultsIt is seen that the contact pressure on the PE insert decreases as the cycle increases for both Flexion and Flexion+AP Translation. It is clear that as the cycle increases, the wear obtained for both cases increases. The loadings acting on the PE insert cannot create sufficient pressure due to the AP Translation effect at low speeds and have an effect to reduce the wear, while the effect increases with the wear as the cycle increases, and the AP Translation now contributes to the wear at high speeds. It is seen that as the posterior tibial slope angle increases, the maximum contact pressure values ​​ slightly decrease for the same cycle.ConclusionsThis study indicated that AP Translation, which changes direction during flexion, had a significant effect on both contact pressure and wear. Unlike previous similar studies, it was seen that the amount of wear continues to increase as the cycle increases. This situation strengthens the argument that loading and AP Translation values ​​that change with flexion shapes the wear effects on PE Insert.
The environmental transfer of psychoactive substances through milk of different origin, is it possible? A case study
Authors: ESTEBAN SARA , DOMINGUEZ-MORUECO NOELIA , FLORES-ANTON BEATRIZ , ESCUDER-VIECO DIANA , GONZALEZ-ALONSO SILVIA , LOPEZ-GARCIA ESTER , POSTIGO CRISTINA , DE ALDA MIREN LOPEZ , SANCHEZ-ROBLES EVA MARIA , GIRON ROCIO , VALCARCEL YOLANDA 
Published: May 2022

Abstract
Psychoactive substances, including drugs such as psychotropic pharmaceuticals, illicit and legal drugs of abuse, and other substances of daily consumption, such as caffeine, are recognised as emerging pollutants. The aim of this study was to determine if these psychoactive substances can be transferred from the environment to the population through milk. Up to 40 psychoactive substances were analysed in various milk matrices, including breast milk, infant formula, and cow’s milk. As for breast milk samples, a self-reported survey was completed by each mother regarding consumption of psychoactive substances during pregnancy and/or breastfeeding. None of the investigated psychoactive substances were detected in any of the matrices analysed, with the exception of the stimulant caffeine, detected in breast milk samples. Cow’s milk and infant formula samples are safe for consumption, as far as presence of psychoactive substances is concerned. Despite that the concentrations of caffeine detected in breast milk samples in this study were high, they are within the limits that are considered safe for newborn feeding and breast milk donation.
Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: A double blind randomized controlled clinical trial
Authors: Salehidoost Rezvan , Boroujeni Golshan Taghipour , Feizi Awat , Aminorroaya Ashraf , Amini Massoud 
Published: May 2022

Abstract
Objectives: To evaluate the effect of magnesium supplementation on insulin resistance and cardiovascular markers in people with prediabetes.Methods: A 12 week clinical randomized double-blind placebo-controlled study on people with prediabetes (n=86) was conducted at Isfahan Endocrine and Metabolism Research Center, Iran, to compare the effects of magnesium oxide 250 mg/day versus a placebo on anthropometric indices blood pressure, fasting glucose, insulin, HOMA-IR index, C-reactive protein, uric acid and lipid profile.Results: Both groups had similar distributions of anthropometric and biochemical variables at baseline. Those who received magnesium supplementation had significantly higher levels of HDL-cholesterol compared to the placebo group at the end of the study (49.7±10.9 vs 43.6±7.2 mg/dL, P=0.003). The mean changes of HOMA-IR index, total cholesterol, LDL-cholesterol, triglyceride, uric acid and C-reactive protein levels as well as anthropometric indices and blood pressure in supplemented and placebo groups did not differ significantly.Conclusions: Magnesium supplementation increased HDL-cholesterol levels in people with prediabetes. However, other cardiometabolic markers were not improved by magnesium supplementation at the above dosage and duration.
Protocol for the development of a core domain set for individuals with ankle osteoarthritis
Authors: Alanazi Sultan Ayyadah , Vicenzino Bill , Bergen Christiaan J.A. van , Hunter David , Wikstrom Erik , Menz Hylton B , Golightly Yvonne , Smith Michelle D 
Published: May 2022

Abstract
BackgroundAnkle osteoarthritis (OA) is a debilitating health condition that is increasing in prevalence. Currently, there are no evidence-based guidelines for managing ankle OA. One of the current challenges to establishing guidelines is the lack of a widely agreed-upon set of outcome measures that are consistently used in ankle OA research. Without a set of agreed-upon outcome measures, it is difficult to synthesise clinical trial outcomes through meta-analysis – an essential element of evidence-informed practice. In order to develop an appropriate set of outcome measures for ankle OA, it is important first to develop a core domain set. In this protocol, we describe the methodological approach that we will use to develop such a core domain set for ankle OA.MethodsWe established an international steering committee to guide the development of a core domain set for ankle OA. The core domain set development will follow a multi-staged approach consisting of three phases, involving participation by patients and clinicians/healthcare professionals. In Phase 1, a list of candidate domains will be gleaned from (a) a systematic review of outcome measures used in ankle OA research, (b) qualitative interviews with individuals with ankle OA, and (c) qualitative interviews with healthcare professionals with expertise in ankle OA. In Phase 2, the steering committee will review and generate a list of candidate domains from those gleaned in Phase 1. In Phase 3, this list of candidate domains will be considered in a Delphi process to reach a consensus on a core domain set. We anticipated this will involve 3 rounds of surveys.ConclusionThis protocol describes the methods that will be used to develop a core domain set of health-related aspects for ankle OA. Importantly, it will include both healthcare professional and patient involvement. This is a prerequisite step to developing a core outcome set for ankle OA that should be reported in all clinical trials for ankle OA. The findings will be widely disseminated across peer-refereed publication(s), national and international conferences, as well as via relevant professional societies, patient support group organisations and social media platforms.Project registrationThis project is registered with the Core Outcome Measures in Effectiveness Trials (COMET) database on 17 March 2021. https://www.comet-initiative.org/Studies/Details/1837.
Evaluation of the contact surface between vertebral endplate and 3d printed patient-specific cages vs commercial cages.
Authors: Fernandes Renan Jose Rodrigues , Gee Aaron , Kanawati Andrew James , Siddiqi Fawaz , Rasoulinejad Parham , Zdero Radovan , Bailey Christopher Stewart 
Published: May 2022

Abstract
Study Design: Biomechanical study.Objective: To evaluate the performance of the contact surface for 3D printed patient-specific cages using CT-scan 3D endplate reconstructions in comparison to the contact surface of commercial cages.Summary of Background Data: Previous strategies to improve the surface of contact between the device and the endplate have been employed to attenuate the risk of cage subsidence. Patient-specific cages have been used to help, but only finite-element studies have evaluated the effectiveness of this approach. There is a possible mismatch between the CT-scan endplate image used to generate the cage and the real bony endplate anatomy that could limit the performance of the cages.Methods: A cadaveric model is used to investigate the possible mismatch between 3D printed patient-specific cages and the endplate and compare them to commercially available cages (Medtronic Fuse and Capstone). Contact area and contact stress were used as outcomes.Results: When PS cage was compared to the Capstone cage, the mean contact area obtained was 100±23.6 mm² and 57.5±13.7 mm², respectively (p<0.001). When compared to the Fuse cage, the mean contact area was 104.8±39.6 mm² and 55.2±35.1 mm², respectively(p<0.001).Conclusion: Patient-specific cages improve the contact area between the implant and the endplate surface, reducing the contact stress and the risk of implant subsidence during LIF surgeries.Level of Evidence: N/A