bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kepuasan Kerja terhadap Kinerja Karyawan pada Hotel Harper Purwakarta
Authors: Suryani Herni , Resniawati Rini 
Published: July 2022

A b s t r a c tThe purpose of this research was to determined and analyzed job satisfaction and employee performance also the influence of job satisfaction on employee performance at The Hotel Harper Purwakarta. The research method used in this research is descriptive and explanatory survey method with the population were employees of The Hotel Harper Purwakarta and with a sample of 69 respondents, the method of data analysis used is a simple regression with data analysis tool SPSS 20. Based on the results of the research concluded that employee job satisfaction at The Hotel Harper Purwakarta Hotel Bandung is in the high category, the performance of the employees of The Hotel Harper Purwakarta Hotel Bandung is in the high category also, and job satisfaction take effects the performance of employees of The Hotel Harper Purwakarta Hotel Bandung. As for the determination coefficient (R2) of job satisfaction on employee performance is 46.60% while 53.40% of employee performance is influenced by other variables not examined of this research. A b s t r a kTujuan penelitian ini ialah untuk mengetahui dan menganalisis kepuasaan kerja dan kinerja karyawan serta pengaruh kepuasaan kerja terhadap kinerja karyawan di Hotel Harper Purwakarta. Metode penelitian yang digunakan adalah metode survey deskriptif dan eksplanatori dengan populasi karyawan Hotel Harper Purwakarta dan sampel sebesar 69 responden menggunakan metode analisis data berupa regresi linier sederhana, yakni alat analisis data SPSS 20. Kemudian dari hasil penelitian disimpulkan bahwa kepuasan kerja karyawan masuk dalam kategori tinggi dan kinerja karyawan masuk dalam kategori tinggi juga serta kepuasan kerja berpengaruh terhadap kinerja karyawan pada Hotel Harper Purwakarta. Adapun koefieisien determinasi (R2) kepuasan kerja terhadap kinerja karyawan adalah sebesar 46,60% sementara itu kinerja karyawan yang dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini sebesar 53,40%.
Modern approaches to the treatment of relapsed follicular lymphoma
Authors: Ryabukhina Yu. E. , Abbasbeyli F. M. , Zeynalova P. A. , Timofeeva O. L. , Batsev A. F. , Allakhverdieva G. F. , Sinitsina O. V. , Zhukov A. G. 
Published: July 2022

Follicular lymphoma is a tumor of mature B-lymphocytes, characterized by a predominantly indolent course. Despite advances in first-line therapy, disease relapses still occur, and with an increase in the follow-up period, the risk of transformation into diffuse large B-cell lymphoma also increases. The choice of a further anticancer therapy is based on the results of a comprehensive examination and repeated biopsy. In addition, previous remission duration, previous treatment, clinical manifestation of relapse, the patient's somatic condition and comorbidity are taken into account. A clinical observation of a 57-year-old patient with relapsed follicular lymphoma, who received various chemotherapy regimens in combination with rituximab in the 1st and subsequent lines, is presented. After repeated biopsy and exclusion of transformation into diffuse large B-cell lymphoma, the patient received lenalidomide therapy in combination with obinutuzumab. A partial antitumor response after 4 cycles with decrease in tumor volume by more than 80 % by the end of induction was achieved. The absence of severe adverse events, together with a pronounced antitumor effect, significantly improved the patient's quality of life.
Comparison of sampling collection strategies for assessing airborne trichloramine levels in indoor swimming pools
Authors: Ahmadpour Elham , Halle Stephan , Valois Isabelle , Ryan Patrick Eddy , Haddad Sami , Rodriguez Manuel , Tardif Robert , Debia Maximilien 
Published: July 2022

Abstract
Since 1995, Hery’s trichloramine sampling procedure has been widely used to determine trichloramine exposure in indoor swimming pools. This method consists of pumping air at a 1 L/min flow rate for 2 hours through a Teflon prefilter and two quartz fibre filters. Modified Hery methods have been reported using different sampling pump flow rates and types of prefilters. Might the prefilter type or sample collection pump flow rate have influenced these studies' results. This study aims to evaluate the effects of different cassette assemblies and sampling flow rates on the levels of measured trichloramine. Laboratory tests were performed using a trichloramine production set-up designed for this study. Workplace measurements were carried out in four indoor swimming pools. Different prefiltering strategies were used: no prefilter, glass prefilter or Teflon prefilter in the sampling cassette, and an original separable prefilter cassette is presented in this study Laboratory tests indicated that in the situation of trichloramine concentrations higher than 1 mg/m³, the trichloramine percentage captured on the first filter could pass the value of 75%, which demonstrates the possible loss of material during the sampling. The investigation of the prefilter effect on sampling strategy using different cassette assemblies revealed that using a separable cassette assembly could prevent overestimating the trichloramine levels. Furthermore, there were no significant differences between measured TCA concentrations at different flow rates (from 0.5 L/min to 2 L/min) in swimming pools.
Subclinical High-Resolution Chest CT Scan Features In Psoriasis
Authors: Samrah Shaher M. , Qarqaz Firas , Obeidat Omar , Bataineh Zineb , Ramadan Anoud , Zubaidi Ghid Al , Alwani Mustafa , Abualnaaj Dina , Za’nouneh Fares J. Abu , Balas Hassan Al , Zoubi Khalid Al , Almomani Yassmen , Samrah Randa S. , Kubbara Aahd F. , Khassawneh Basheer Y. 
Published: July 2022

Abstract
Background: Although psoriasis is considered a systemic disease, no clear association has been established between psoriasis and lung diseases. This study aims to detect and describe subclinical pulmonary involvement in psoriasis patients with various degrees of cutaneous manifestations.Methods: Adult psoriasis patients with no known active pulmonary disease or respiratory symptoms were screened for subclinical pulmonary manifestations and possible parenchymal changes using high-resolution computed tomography (HRCT) scan of the chest. Patients were classified according to the severity of skin manifestations. The clinical characteristics and radiographic findings of these patients were evaluated.Results: Fifty-nine patients with psoriasis were included, among which 47 (79.7%) had abnormal HRCT scan features. Micronodules were the most common detected lung lesions (66.1%), followed by nonspecific interstitial changes (32.2%), including pleuro-parenchymal band/atelectasis, scarring, and focal ground-glass opacities. Other HRCT findings included emphysematous changes and calcified granulomas. Abnormal HRCT findings correlated with older age and duration of psoriasis but not with the severity of skin manifestations.Conclusions: Micronodules and minor focal nonspecific interstitial changes were the most detected lung alterations in patients with psoriasis. These findings of the pilot study highlight a possible pulmonary involvement in patients with psoriasis. Larger multicenter studies are needed to clarify these findings further.
Improving Venture Investment Tools: Neutralizing Financial risks and Achieving Sustainable Development Goals
Authors: Matytsin Denis , Inshakova Agnessa , Anisimov Aleksey 
Published: July 2022

Abstract
This paper’s goal is to study the effect of venture capital investments on the financial risks of sustainable development, determine the change of the financial risks of implementing the SDGs (from the standpoint of venture capital investments) under the impact of the COVID-19 pandemic and crisis, and to discover the perspectives of risk management. This paper’s originality lies in proposing and substantiating a new (additional) criterion of classification of venture capital investments from the standpoint of their consequences for the SDGs – the object of venture capital investments (a thematic block of the SDGs). This paper’s uniqueness is due to it allowing using the proposed new (particularly useful in practice) criterion to identify the financial risks of sustainable development, to quantitatively measure the change of the financial risks of implementing the SDGs (from the standpoint of venture capital investments) under the impact of the COVID-19 pandemic and crisis, and determine the practical perspectives of risk management. Management implications are as follows: this paper forms a scientific basis for improving the implementation of the mechanism of venture investment to support the SDGs within the manifestation of corporate social responsibility in business. The practical significance of the authors’ conclusions is due to them allowing for the improvement of the practice of decision making regarding the placement of venture capital investments.
An Effective and Chemotherapy-free Strategy of All-trans Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia in All Risk Groups
Authors: Wang Huai-Yu , Gong Sha , Li Guo-Hui , Yao Ya-Zhou , Zheng Yin-Suo , Lu Xiao-Hong , Wei Su-Hua , Qin Wei-Wei , Liu Hai-Bo , Wang Meng-Chang , Xi Jie-Ying , Chen Limei , zhang mei , Zhang Xin-Xin , Zhang Hui-Yun , Zhang Cheng-Shang , Wald David , Zhu Hong-Hu , Liu Li , He Peng-Cheng 
Published: July 2022

Abstract
The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has been demonstrated to be at least equally effective to ATRA and chemotherapy (CHT) in non-high-risk acute promyelocytic leukemia (APL). However, the efficacy of ATRA-ATO compared to ATRA-ATO plus CHT in high-risk APL remains unknown. Here we performed a randomized multi-center non-inferiority phase III study to compare the efficacy of ATRA-ATO and ATRA-ATO plus CHT in newly diagnosed all-risk APL to address this question. Patients were assigned to receive ATRA-ATO for induction, consolidation and maintenance or ATRA-ATO plus CHT for induction followed by three cycles of consolidation therapy, and maintenance therapy with ATRA-ATO. In the non-CHT group, hydroxyurea was used to control leukocytosis. A total of 128 patients were treated. The complete remission rate was 97% in both groups. The 2-year disease-free, event-free survival rates in the non-CHT group and CHT group in all-risk patients were 98% v 97%, and 95% v 92%, respectively (P = 0.62 and P = 0.39, respectively). And they were 94% v 87%, and 85% v 78% in the high-risk patients (P = 0.52 and P = 0.44, respectively). This study demonstrated that ATRA-ATO had the same efficacy as the ATRA-ATO plus CHT in the treatment of patients with all-risk APL.
Glucose as a risk factor for periodontitis in kidney transplantation patients.
Authors: Young-Min Shin , Mun Kwang Ho 
Published: July 2022

Abstract
Background: Various factors including diabetes and oxidative stress are associated with periodontal inflammation. In patients with end stage renal disease (ESRD) lead to various systemic abnormalities, including cardiovascular disease, metabolic abnormalities, and infection. Even after kidney transplantation (KT), these factors are known to be associated with inflammation. Our study, therefore aimed to study risk factors associated with of periodontitis in KT patients. Methods: Patients, who visited Dongsan Hospital, Daegu, Korea, since 2018, of whom have undergone KT were selected. As of November 2021, 923 participants, with full data including hematologic factors were studied. Periodontitis was diagnosed based on residual bone level in panoramic views. Patients were studied by the presence of periodontitis.Results: From 923 KT patients, 30 were diagnosed with periodontal disease. Fasting glucose levels were higher in patients with periodontal disease, while total bilirubin levels were lower. When divided by fasting glucose levels, high glucose level showed increase of periodontal disease with odds ratio (OR) of 1.031 (95% confidence interval (CI) 1.004-1.060). After adjusting for confounders, results were significant with OR 1.032 (95% CI 1.004-1.061). Conclusions: Our study have shown that KT patients, of whom uremic toxin clearance has been revolted, are yet at risk of periodontitis by other factors, such as high blood glucose levels.
Measuring melatonin via fast-scan cyclic voltammetry: differentiation of melatonin and by-product matrices to enable long term recording
Authors: Lumsden Susannah , Cakmak Yusuf , Clarkson Andrew , Hyland Brian , Fuller Justine 
Published: July 2022

Abstract
Melatonin, a hormone involved in regulating multiple bodily functions, is a potential therapeutic target in several conditions. Fast-scan cyclic voltammetry (FSCV) measures electroactive substances in discrete body locations in real-time with high temporal resolution. However, in long term experiments a fouling substance develops and generates an oxidation peak in the voltammograms, making it difficult to infer pure melatonin current for analysis. We report a method for constructing melatonin and by-product matrices to circumvent this problem. Sweeps prior to fouling peak development provide a pure melatonin waveform. For each of five calibrations of increasing melatonin aliquots, this waveform was scaled to map it onto sweeps during stable melatonin concentration. The scaled waveform for melatonin (the melatonin matrix) was subtracted from the composite waveform to isolate the signal of the fouling substance (by-product matrix). The isolated melatonin and by-product matrices were applied to principal components regression analysis of in vitro experiments. We examined the quantification of melatonin and distinction from noradrenaline (NA), N-acetyl serotonin (NAS), 5-hydroxyindole-3-acetic acid (5-HIAA) and serotonin (5-HT). Results confirmed excellent interpretation of melatonin concentration changes over a six-minute period, better selectivity for melatonin, and more accurate measurement of the known concentration, compared with using the original composite voltammograms.
Sampling Frequency Thresholds for Quantum Advantage of Quantum Approximate Optimization
Algorithm
Authors: Lykov Danylo , Wurtz Jonathan , Poole Cody , Saffman Mark , Noel Tom , Alexeev Yuri 
Published: July 2022

Abstract
In this work, we compare the performance of the Quantum Approximate Optimization Algorithm (QAOA) with state-of-the-art classical solvers such as Gurobi and MQLib to solve the combinatorial optimization problem MaxCut on 3-regular graphs. The goal is to identify under which conditions QAOA can achieve “quantum advantage” over classical algorithms, in terms of both solution quality and time to solution. One might be able to achieve quantum advantage on hundreds of qubits and moderate depth p by sampling the QAOA state at a frequency of order 10 kHz. We observe, however, that classical heuristic solvers are capable of producing high-quality approximate solutions in linear time complexity. In order to match this quality for large graph sizes N, a quantum device must support depth p > 11. Otherwise, we demonstrate that the number of required samples grows exponentially with N, hindering the scalability of QAOA with p ≤ 11. These results put challenging bounds on achieving quantum advantage for QAOA MaxCut on 3-regular graphs. Other problems, such as different graphs, weighted MaxCut, maximum independent set, and 3-SAT, may be better suited for achieving quantum advantage on near-term quantum devices.
The pyroptosis related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma.
Authors: Jin Jinji , Zhuang Xiaopeng , Chen Wenjing , Cai Yiqi , Zhu Guanbao , Wang Pengfei , Tu Jianxin 
Published: July 2022

Abstract
Background
Dedifferentiated liposarcoma, a member of malignant mesenchymal tumors, has a high local recurrence rate and poor prognosis. Pyroptosis, a newly discovered programmed cell death, is tightly connected with the progression and outcome of tumor. However, the role of pyroptosis in Dedifferentiated liposarcoma remained unclear.
Methods
We obtained the RNA sequencing data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases to identify different pyroptosis-related genes (PRGs) expression patterns. An unsupervised method for clustering based on PRGs was performed. Clinical outcomes and immune microenvironment varied with the clusters according to the result of cluster analysis. The differentially expressed genes between the two clusters were used to develop a prognosis model by LASSO Cox regression method, followed by the performance of functional enrichment analysis and single-sample gene set enrichment analysis(ssGSEA). All of the above results were validated in Gene Expression Omnibus (GEO) dataset.
Results
Forty-one differentially expressed PRGs were found between tumor and normal tissues. DDL patients were classified into two clusters using consensus clustering analysis based on PRGs. Cluster 2 showed a better outcome, higher immune scores, stronger immune cells abundances, and elevated expression levels in numerous immune checkpoints compared with Cluster 1. Differentially expressed genes (DEGs) between clusters were identified. A total of 5 gene signature was built based on the DEGs and divided all DDL patients of the TCGA cohort into low-risk and high-risk groups. The low-risk group indicated greater inflammatory cell infiltration and better outcome. External validation verified significant differences of survival and immune landscape again between two risk groups of GEO cohort. Receiver operating characteristic (ROC) curves implied that risk model could exert its great value in predicting DDL patients’ prognoses.
Conclusion
Our findings revealed the clinical implication and key role in tumor immunity of pyroptosis-related genes in dedifferentiated liposarcoma. The risk model is a promising predictive tool, which could provide a fundamental basis for future studies and individualized immunotherapy.
Embedding Ceramic Components in Metal Structures with Hybrid Directed Energy Deposition
Authors: Feldhausen Thomas , Yelamanchi Bharat , Gomez Alexander , Du plessis Anton , Saleeby Kyle , Fillingim Kenton , Post Brian , Love Lonnie , Cortes Pedro , MacDonald Eric 
Published: July 2022

Abstract
The combined benefit of both additive and subtractive manufacturing within the same gantry system enables hybrid directed energy deposition to create complex geometries with smooth surface finish and superior dimensional accuracy. Moreover, with layer-by-layer access to the structure during both the addition and subtraction of material, the insertion of components is now possible, assuming the components can survive the high temperatures associated with the subsequent metal deposition. Ceramic inserts are of interest for a variety of reasons including: (1) to create complex interwoven ductile / brittle composites for ballistics, or (2) to integrate high temperature strain or temperature sensors protected within ceramic substrate subsumed into a larger metal structure. In this work, steel substrates were machined to create an internal cavity for insertion of a ceramic component. During the investigation of several different over-the-ceramic deposition strategies, components were inserted and different sequences were continued to envelop the inserted ceramic with varying success. Unmelted powder served as both a thermal buffer and to provide a flush surface upon which the laser cladding could continue. Subsequent depositions were attempted with both dry and wet powder (addition of machining coolant to wet) providing stability and minimizing displacement caused by the gas flow. Finally, the use of an oblique angle for laser cladding allowed for the redirection of some fraction of the introduced thermal energy away from the ceramic, and consequently, improved the survival of the inserts. With this combination of techniques, ceramic inserts survived full embedding within a complex steel structure.
Optimum Toolpath Planning Strategy Prediction using Machine Learning Technique
Authors: Kukreja Aman , Pande Sanjay S 
Published: July 2022

Abstract
Finding the best toolpath planning strategy for Computer Numerical Control (CNC) machining requires a trial-and-error approach. One needs to follow a number of steps, viz., generate the toolpath, perform simulations/machining, measure various parameters to quantify the quality of the toolpath, and then select the best toolpath. This conventional iterative approach is time-consuming and often error-prone. This paper presents a novel Machine Learning based system for choosing the best toolpath planning strategy for CNC machining (finishing) of complex freeform surfaces directly from the CAD model. Three tool path planning strategies are considered, viz. Adaptive planar, Iso-scallop, and Hybrid. At first, a novel toolpath analysis module is presented to evaluate the quality of the toolpath considering performance parameters such as the surface finish, toolpath length, and smoothness. The toolpath analysis module was extensively tested for robustness and accuracy. This quality measurement technique is then used to analyze and label a large number of CAD models to create a dataset for supervised learning for the three toolpath strategies. A Convolutional Neural Network (CNN) model is designed to predict the best toolpath planning strategy. Results show that the proposed data-driven model achieved 96.8% test accuracy.
Use of ramucirumab for various treatment lines in real-world practice of patients with advanced hepatocellular carcinoma
Authors: Kanogawa Naoya , Ogasawara Sadahisa , Maruta Susumu , Iino Yotaro , Obu Masamichi , Ishino Takamasa , Ogawa Keita , Yumita Sae , Iwanaga Terunao , Unozawa Hidemi , Nakagawa Miyuki , Fujiwara Kisako , Sakuma Takafumi , Fujita Naoto , Kojima Ryuta , Kanzaki Hiroaki , Koroki Keisuke , Kobayashi Kazufumi , Inoue Masanori , Kiyono Soichiro , Nakamura Masato , Kondo Takayuki , Saito Tomoko , Nakagawa Ryo , Nakamoto Shingo , Muroyama Ryosuke , Chiba Tetsuhiro , Itobayashi Ei , Koma Yoshihiro , Azemoto Ryosaku , Kato Jun , Kato Naoya 
Published: July 2022

Abstract
Purpose: Ramucirumab was shown to be effective as a second-line treatment after sorafenib in patients with advanced hepatocellular carcinoma (HCC) with alpha-fetoprotein levels >400 ng/mL in a worldwide phase 3 trial. Ramucirumab is used in patients pretreated with various systemic therapies in clinical practice. We retrospectively examined the treatment outcomes of ramucirumab administered to advanced HCC patients after diverse systemic therapies.Methods: Data were collected from patients with advanced HCC who received ramucirumab at three institutions in Japan. Radiological assessments were determined according to both Response Evaluation Criteria in Solid Tumours (RECIST) version 1.1 and modified RECIST and the Common Terminology Criteria for Adverse Events version 5.0 was used to assess adverse events.Results: A total of 37 patients treated with ramucirumab between June 2019 and March 2021 were included in the study. Ramucirumab was administered as second, third, fourth, and fifth-line treatment in 13 (35.1%), 14 (37.8%), eight (21.6%), and two (5.4%) patients, respectively. Most patients (29.7%) who received ramucirumab as a second-line therapy were pretreated with lenvatinib. The median progression-free survival of patients treated with ramucirumab was 2.7 months (95% confidence interval, 1.6–7.3). There were no notable adverse events and no significant changes in albumin bilirubin score during ramucirumab treatment.Conclusion: Although ramucirumab is used for various lines of treatment other than second-line immediately after sorafenib, its safety and efficacy were not significantly different from the findings of the REACH-2 trial.