bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elexacaftor-Tezacaftor-Ivacaftor and Ivacaftor (Trikafta)
Authors: CADTH  
Published: July 2022

CADTH recommends that Trikafta should be reimbursed by public drug plans for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least 1 F508del mutation in the CFTR gene if certain conditions are met.
At least 1 of the following must be demonstrated after 6 months of treatment with Trikafta: an increase of at least 5% in percent predicted forced expiratory volume in 1 second (ppFEV1), a decrease in the number of pulmonary exacerbations or number of days that antibiotics are needed to be taken for pulmonary exacerbations, a decrease in CF-related hospitalizations, no decline in body mass index, or an improvement of at least 4 points in the Cystic Fibrosis Questionnaire-Revised respiratory domain scale. The price of Trikafta must be lowered to be cost-effective and affordable.
Evaluation of lidar-assisted wind turbine control under various turbulence characteristics
Authors: Guo Feng , Schlipf David , Cheng Po Wen 
Published: July 2022

Abstract. Lidar systems installed on the nacelle of wind turbines have the capability to provide a preview of incoming turbulent wind. Lidar-assisted wind turbine control (LAC) allows the turbine controller to react to changes in the wind before they affect the wind turbine. Currently, the most proven LAC technique is the collective pitch feed-forward control, which has been found to be beneficial for load reduction. In literature, the benefits were mainly investigated using standard turbulence parameters suggested by the IEC 61400-1 standard and assuming Taylor's frozen hypothesis (the turbulence measured by the lidar propagates unchanged to the rotor). In reality, the turbulence spectrum and the spatial coherence change by the atmospheric stability conditions. Also, Taylor's frozen hypothesis does not take into account the coherence decay of turbulence in the longitudinal direction. In this work, we consider three atmospheric stability classes: unstable, neutral, and stable, and generate four-dimensional stochastic turbulence fields based on two models: the Mann model and the Kaimal model. The generated four-dimensional stochastic turbulence fields include the longitudinal coherence thus avoiding assuming Taylor's frozen hypothesis. The Reference Open Source Controller (ROSCO) is used as the baseline feedback-only controller. A reference lidar-assisted controller (LACer) is developed and used to evaluate the benefit of LAC. Considering the NREL 5.0 MW reference wind turbine and a typical four-beam pulsed lidar system, it is found that the filter design of the LACer is not sensitive to the turbulence characteristics representative of the investigated atmospheric stability classes. The benefits of LAC are analyzed using the aeroelastic tool OpenFAST. According to the simulations, LAC's benefits are mainly the reductions in rotor speed variation (15 % to 40 %), tower fore-aft bending moment (2 % to 18.8 %), and power variation (3 % to 20 %). This work reveals that the benefits of LAC can depend on the turbulence models, the turbulence characteristics, and the mean wind speed.
PENTINGNYA SURAT PEMBERITAHUAN DIMULAINYA PENYIDIKAN (SPDP) BAGI PARA PIHAK DEMI TERCIPTANYA DUE PROCES OF LAW
Authors: Saputra Trias , Mauli Hutagalung Jatarda 
Published: July 2022

Tujuan dari penelitian ini untuk mengkaji serta menguraikan penerapan pasal 109 ayat (1) Undang-Undang Nomor 8 Tahun 1981 Tentang Hukum Acara Pidana (KUHAP) terkait Surat Pemberitahuan Dimulainya Penyidikan (SPDP). SPDP tersebut disampaikan oleh penyidik kepada penuntut umum guna menjamin penerapan fungsi pengawasan perkara yang dimiliki Penuntut Umum. Melalui Putusan Nomor 130/PUU-XIII/2015 Mahkamah Konstitusi menyatakan frasa “penyidik memberitahukan hal itu kepada Penuntut Umum” inskonstitusional bersyarat sehingga SPDP menjadi wajib diserahkan kepada Penuntut Umum, terlapor dan korban/pelapor paling lambat 7 (tujuh) hari setelah dikeluarkan surat perintah penyidikan. Dalam praktiknya penerapan pasal ini masih jauh dari harapan sebagaimana yang termuat dalam Putusan Mahkamah Konstitusi tersebut. Metode yang digunakan dalam penelitian ini ialah Yuridis-Normatif dengan menggunakan data sekunder atau data kepustakaan (library research) dengan pendekatan Perundang-undangan (The Statute Approach).
Kata Kunci: SPDP, Putusan Mahkamah Konstitusi Nomor 130/PUU-XIII/2015.
PERLINDUNGAN HUKUM BAGI KREDITUR TERHADAP PELAKSANAAN EKSEKUSI JAMINAN FIDUSIA (ANALISIS PUTUSAN MAHKAMAH KONSTITUSI NO 18/PUU-XVII/2019)
Authors: Jadidah Fikrotul 
Published: July 2022

Terbitnya putusan MK No 18/PUU-XVII/2019 didasari adanya permohonan uji materiil terhadap Pasal 15 Ayat (2) dan Ayat (3) UU No 42 Tahun 1999 tentang Jaminan Fidusia yang memberikan perubahan hukum baru mengenai pengaturan dan pelaksanaan tata-cara eksekusi objek jaminan fidusia sebelum dan sesudah adanya putusan MK No 18/PUU-XVII/2019 dan bentuk perlindungan hukum bagi kreditur apabila debitur melakukan cidera janji (wanprestasi). Metode penelitian yang digunakan adalah yuridis normatif dengan spesifikasi penelitian deskriptif analitis. Dari hasil penelitian ini diperoleh kesimpulan yaitu pengaturan eksekusi objek jaminan fidusia sebelumnya diatur di dalam pasal 29 - 34 Undang-Undang No 42 Tahun 1999 tentang Jaminan Fidusia, namun setelah adanya uji materiil terhadap Undang-Undang tersebut maka pengaturan dan pelaksanaannya sesuai dengan Putusan MK No 18/PUU-XVII/2019 Dan Peraturan Kepolisian Negara RI No 8 Tahun 2011 tentang Pengamanan Eksekusi Jaminan Fidusia. Dan bentuk perlindungan hukum bagi kreditur apabila debitur wanprestasi yaitu pengajuan permohonan pengangkatan penangguhan atas hak eksekusinya sesuai mekanisme yang berlaku pada Undang-Undang No 37 Tahun 2004 tentang Kepailitan dan Penundaan Kewajiban Pembayaran Utang. Saran dari penelitian ini adalah melakukan perubahan terhadap isi Undang-Undang No 42 Tahun 1999 tentang Jaminan Fidusia, selain itu melakukan penambahan atau mengubah klausul akta notaris jaminan fidusia dengan mengakomodir syarat-syarat dalam putusan MK No 18/PUU-XVII/2019 serta memanfaatkan mekanisme gugatan sederhana guna mengefisiensi proses penyelesaian perkara.
“O Samba de Aboio é de Santa Barbara”: celebração, fé e resistência cultural numa comunidade negra sergipana
Authors: Souza de Assis Yérsia 
Published: July 2022

O/A Samba de Aboio/Festa de Santa Barbara é uma festa/prática de fé que acontece todos os anos no povoado Aguada, na cidade de Carmópolis, no estado de Sergipe (SE). Fundada por uma africana chamada Tamashalim Ecuobanker, a festa acontece em celebração à abolição da escravatura (1888), e concomitantemente são feitas devoções à Iansã/Santa Barbara. A festa que tem como marco histórico o ano de 1888 vem atravessando gerações da Mota e Assis, família que é detentora do legado iniciado por Tamashalim. A família Mota e Assis junto com a comunidade do povoado Aguada são os agentes mantenedores dessa prática de fé, que é também festiva. Este trabalho pretende discutir alguns aspectos que envolvem a organização e promoção desta festa/prática de fé, compreendendo que essa manifestação de fé e festa apontam para os muitos tipos de estratégias de resistências da cultura negra no Brasil. O artigo articula-se a partir das bibliografias que discutem a temática. Somado a isso, utilizo dados etnográficos de pesquisas de campo previamente realizadas.
Spanish Classical Theater in COVID-19 Times: How Andalusian Companies Dealt with the 2020 Pandemic
Authors: Moreno Laura Ramiro 
Published: July 2022

Abstract:
With the closure of theaters in March of 2020 due to the COVID-19 pandemic, theatrical companies in Spain were forced to change their seasonal programs. After interviewing actors, directors, and producers from different provinces of Andalusia who work with classical theater, this work exposes the difficulties that theater practitioners faced during the closures of the theaters and how they adapted to the restrictions imposed upon the reopening of theatrical spaces. These professionals explained what could or could not be adapted from their work, how long this adaptation took (or would have taken), and what other barriers they faced that are not obvious for laypersons. Furthermore, this article introduces these companies’ opinions on virtual adaptations, recordings, and other alternative forms of theater. Finally, this work reveals how theater practitioners see the future of theater and comedia after the emergence of digital performances during the pandemic.
use of nanoparticle form of milled teeth as a bone graft substitute in rabbits
Authors: Mohammed Saber Mizher , Rejeb Atalla F 
Published: July 2022

Aims of the study: This study was designed to determine the effects of milled tooth in its nanoparticle forms as a bone substitute materials on the acceleration of bone healing in rabbits. Materials and Methods: Sixteen albino rabbits were used in the experiment that were divided into two groups: nanoparticle group (M0 group) and control group. Rabbits were anesthetized using intramuscularly administered 10% ketamine (40mgkg) and 2% xylazine (5mgkg) (Inferchemi, Holland). After shaving and sterilization of the site of the operation, a 2cm submandibular incision was done. Then 3 millimeter circular anterior full-thickness defect was created near the midline of the mandible. The anterior defect was filled with 50-100nm milled tooth material nanoparticles. The incision was sutured with 3/0 black silk. Following surgery, each rabbit was given 30 mg/kg oxytetracycline intramuscularly. The rabbits were euthanized at 3, 7, 14, and 28 days afterwards. Then the specimens were dried and fixed in paraffin before being removed from the skulls. Histological examination the specimens was done.
Introducción. Géneros y sexualidades, ¿y músicas populares?
Authors: Montes María de los Ángeles , Argüello Silvina 
Published: July 2022

En las últimas décadas las ciencias sociales han desarrollado un enorme interés por el modo como se producen los géneros y sexualidades, así como por las relaciones de poder de las que emergen y que contribuyen a sostener o desafiar.
Y aunque es cierto que los géneros sexuales no son fenómenos meramente discursivos, también es cierto que los discursos intervienen de manera innegable en la producción de masculinidades hegemónicas y feminidades enfatizadas (Connel y Messerschmidt, 2021), por ejemplo. Y, también, que las prácticas a través de las cuales se hace género, con las que se reproducen o se disputan definiciones, tienen una dimensión significante y, en ese sentido, pueden ser leídas como discursos. Esto es así por la doble determinación social de la que hablaba Eliseo Verón (1993): Todo discurso es un hecho social -que interviene en la realidad- y todo hecho social es, en una de sus dimensiones constitutivas, resultado de un proceso de producción de sentido y, por lo tanto, puede ser analizado en clave discursiva.
Botas, trenzas y glitter: Estrategias para visibilizar las disidencias en el Folklore Argentino
Authors: Díaz Natalia Elisa 
Published: July 2022

En el marco del folklore argentino, entendido como campo de producción simbólica, se ha construido una cultura afectiva y un conjunto de repertorios sociales que solo pueden ser comprendidos bajo una matriz heteronormativa. Sin embargo, en los últimos años, al folklore han arribado gauchos montados con arneses y tacones de aguja, copleras trans que les cantan a los asesinatos de travestis o transformistas que bailan al ritmo de huaynos para cuestionar la construcción LGTBQI+ que reafirma una femineidad blanca y occidental.
Mediante herramientas provenientes de la sociología del discurso y de la cultura, el presente trabajo se construye en torno a los siguientes interrogantes: ¿a través de qué estrategias las disidencias buscan visibilizarse en las narrativas identitarias construidas por el campo del folklore? ¿Cómo abordar la heterogeneidad de las sexualidades disidentes? ¿Es posible construir una perspectiva queer del ser nacional?
Attention Performance Decline After Age 40 in Clinically Normal Community Dwellers: Evidence from a 10-Year Follow-Up of the Yakumo Study
Authors: Hatta Takeshi , Kimura Takahiko , Hatta Taketoshi , Iwahara Akihiko 
Published: July 2022

Abstract
Age-related changes in attention ability and differences by gender in the rates of change from middle age were investigated. Digit Cancellation Test (D-CAT1 and D-CAT3 conditions, which involve low and high cognitive load, respectively) scores and individually calculated decline rates (DRs) in 10-year follow-up among four age groups (40s, 50s, 60s, and 70s) were examined. Performance in both D-CAT conditions declined with increasing age from the 50s to the 70s, whereas there was no difference between the 40s and 50s, and a gender difference (with the women showing an advantage) was demonstrated in the 40s and 50s groups on the D-CAT3. In the D-CAT1 condition, the DR remained stable from the 40s to the 50s but increased from the 50s and to the 60s and then remained the same. In the D-CAT3 condition, the DR became larger even after the 70s. The DRs did not differ between men and women from middle age onward. Although DRs showed no gender difference, D-CAT performance showed a gender difference, with men being about 20% less capable by the age of 40. We suggest that data showing concrete declines in attentional performance after middle age may be used to reduce accidents encountered in the daily life of older adults.
Comparing Inverted Faces to Upright Faces Using Similarity or Mental Rotation
Authors: Rakover Sam S. , Bar-On Rani Amit , Gliklich Anna 
Published: July 2022

Abstract
A major interest of research in face recognition lies in explaining the face inversion effect, in which the recognition of an inverted face is less successful than that of an upright face. However, prior research has devoted little effort to examining how the cognitive system handles comparison between inverted and upright faces. The results of a preparatory experiment and two following experiments support the conclusion that the comparison is based more on visual similarity than on a mental rotation of the inverted face to an upright face. Visual similarity is based on certain elements mutual to the two faces, which resist the transformation of inversion. These elements are symmetric or salient components of the face, such as round eyes or thick lips.
How Will the Occupation End? A Real-World Exploration of Hindsight Bias and Retroactive Pessimism Concerning Antigovernment Protests in Bulgaria
Authors: Rachev Nikolay R. , Petrova Mila 
Published: July 2022

Abstract
We explored hindsight bias and retroactive pessimism related to the occupation of Sofia University in 2013–2014, using a memory design. We found partial evidence for hindsight bias for predictions of whether the occupation would achieve its goal (the government's resignation) but not for specific events related to the occupation, which were deemed unlikely from the start and later perceived not to have occurred. We did not find evidence for retroactive pessimism: Hindsight bias indices for the prediction of the government's resignation were not reliably associated with support for the occupation and disappointment with its outcome. We propose using a recall/reconstruct measure as a more rigorous test for retroactive pessimism, which has so far been demonstrated through reassessment.
Postoperative Acute Kidney Injury With Dual NSAID Use After Outpatient Primary Total Joint Arthroplasty
Authors: Mittal Ashish , Tamer Pierre , Shah Ishan , Cortes Alejandro , Hinman Adrian D. 
Published: July 2022

Background:
NSAIDs have been shown to be highly effective analgesic agents in the postoperative period. NSAIDs do have several potential adverse effects, including kidney injury (AKI). Little is known about AKI in the outpatient total joint arthroplasty (TJA) setting, where patient labs are not closely monitored. The objective of this study was to evaluate the renal safety of combined use of ibuprofen for pain control and aspirin for deep vein thrombosis chemoprophylaxis after outpatient primary TJA.

Methods:
Patients undergoing primary total hip or total knee arthroplasty between January 2020 and July 2020 at a single center were included for analysis. All included patients were discharged on a standard regimen including aspirin 81 mg twice a day and ibuprofen 600 mg three times a day. Patients were ordered a serum creatinine test at 2 and 4 weeks postoperatively. Patients with postoperative acute kidney injury were identified per Acute Kidney Injury Network criteria.

Results:
Between January 23, 2020, and August 30, 2020, 113 patients were included in this study, of whom creatinine levels were measured in 103 patients (90.3%) at the 2-week postoperative time point, 58 patients (50.9%) at the 4-week time point, and 48 (42.1%) at combined 2- and 4-week time points. Three patients (2.9%) were found to have an AKI.

Conclusion:
This study found a rate of AKI of 2.9% with the use of dual NSAID therapy postoperatively after primary TJA. All cases occurred at 2 weeks postoperatively and saw spontaneous resolution.
Evaluation of Breast Lesions Using Mammography
Authors: Mah Noor . , John Akash , Ali Abid , Yousaf Amna , Bakhtawar Khadija 
Published: July 2022

The second leading cause of death is breast cancer and annual mammograms have been found to incite the early identification of breast cancer.The diagnosis of cancer at initial stage is helpful in lowering the mortality rate. The most prevalent pathologies of breast cancer are swelling, cysts, and adenosis, and benign or malignant tumors. Objective: To evaluate Breast Lesions Using Mammography.Method: It was a cross-sectional study comprised of a sample size of 47 female patients, calculated via a convenient sampling approach. Women with age of 29 years and above were included in this study. The study was performed in Faisalabad, Pakistan from December 2021 to March 2022. The digital mammographic equipment was used in this study and data was entered and analyzed by SPSS version 20. Results: The majority 33(70.2%) patients were included in 30-49 years age group while least were 2(4.3%) in 70 and above. The ill-defined shape tumors were 18 (38.3%) and the the microlobulated shaped tumors were 1(2.1%). The tumors with well-defined margin were 17(36.2%) and tumors with ill-defined margin were 1(2.1%). The tumors without calcification were 31(66%) and the calcified tumors were 16(34%). The tumors with involvement of lymph nodes were 30(63.8) and tumors with single lymph node involved were 1( 2.1%) Conclusion: A mammogram is necessary for determining the stage of breast cancer. A mammogram can be very useful to determine the location and shape of the lesion for demonstrating a lesion's radiographic features.
Association of Obesity with Food Choices among Children Between Age Group of 5 To 12 Years in Different Areas of Lahore
Authors: Tahir Hafsa , Maqbool Sania , Shahid Shafaq , Shabbir Riffat , Uzair Asghar Hafiz Muhammad , Masood Fizza , Naeem Amna , Irfan Fizah 
Published: July 2022

The relationship between the socioeconomic status (SES) of parents and the effect of socio-economic status on the food intake pattern of their children was examined in this study. Children of low SES generally have poorer diets than children of high SES. Objective: To observe the association of child obesity with food choices in different areas of Lahore Methods: Data were collected from 38 participants, from different areas of Lahore, Pakistan. From which 20 were female and 18 were male children. Their parents were requested to solve a questionnaire which comprised of different questions related to child age, height, weight, eating habits and parent’s socioeconomic status and their education. Results: Study showed that children growing up in families with a lower SES had a higher body mass index (BMI), lower quality of life, less healthy nutrition, and less physical activity as compared to children growing up in families with a higher SES. The food frequency questionnaire showed that children belonging to lower SES consumed 17% grains, 18% dairy sources, 16% vegetables, 12% pluses and lentils, 0% meat, 11% fruits, and 13% tea and coffee in a day. While children belonging to higher SES consumed 17% grains, 29% dairy sources, 6% vegetables, 2% pulses and lentils, 13% meat, 13% fruits, and 7% tea and coffee daily. Conclusions: SES has an exquisite impact at the food alternatives and food intake among college-going youngsters. Lower SES children devour greater veggies, less meat, and dairy products at the same time as better SES kids devour fewer vegetables and extra meat and dairy products. Children from DHA were more obese and they were consuming more protein based diet and practicing sedentary life style.
Attitude Of Final Year Doctor of Physical Therapy Students Towards Direct Access
Authors: Tahir Armaghan , Saad Hassan Muhammad , Mohammad Latif Mohammad Jawwad , Mohammad Latif Saadia Batool , Fahad Khalid Sheikh , Faizan Hamid Muhammad 
Published: July 2022

Direct access in physical therapy means the removal of a medical practitioner’s referral directed by the country’s law to access services of physical therapists for patient evaluation and treatment. students are the future of any country. Objective: To describe the attitude of physical therapy students in their final year towards direct access in Pakistan. Methods: A cross-sectional study was conducted on a sample size of 500, over a period of six months. A semi-structured questionnaire was developed to determine the desired objectives. Data was analyzed by using SPSS 21. Results: 62.8% students agreed and 30% students strongly agreed to practice under direct access after graduating. Conclusions: The study concludes that most physical therapy students are ready to practice under direct access in Pakistan after graduating.
An In Vitro Study of Histology of Nonfluorosed and Fluorosed Bone
Authors: Sarfaraz Khan Zahid , Ataullah Muhammad , Gulrukh Saba Shah Syeda , Naeem Nabiha , Aslam Maryam , Khalid Aqsa , Shehzadi Ulfat , Akram Muhammad , Ullah Irfan 
Published: July 2022

The study of the epidemiologic association between fluorosis and periodontitis, as well as the effects of fluorosis on periodontal tissues and the effects of periodontal therapy on teeth of non-fluorosed and fluorosed. There has been limited research into the effects of fluorosis on organic tissues for example bones. The biomechanical, histology and biochemical properties of fluorosed bones have still not been studied in alveolar bone, which, like extremities, is an important component of the periodontal tissue. Objective: The goal of this research was to compare the histology of fluorosed femur bones to that of non-fluorosed femur bones. Method: 40 non-fluorosed and fluorosed healthy bone (femoral) samples were tested using a microscope to compare and assess the histology of non-fluorosed with fluorosed bone. Results: When comparing the non-fluorosed group (11.835.21, 9.853.45) to the fluorosed group (7.724.42, 6.702.42), bone of cortical and cancellous cellularity was shown to be substantial in term of statistics. The non-fluorosed and fluorosed bone had the same trabecular density statistically not significant, p-value is equal to 0.726]. Nonfluorosed bone had thick trabeculae, while fluorosed bone had short and thin trabeculae. Conclusion: The identified histologic variations could affect the pathogenesis of periodontitis / the efficacy of periodontal therapy. In widespread fluorosed regions, dental fluoride could likely be identified as an important public health issue.