bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field programmable gate array implementation of an adaptive filtering based noise reduction and enhanced compression technique for healthcare applications
Authors: Aruna Viswanadham Baby Koti Lakshmi , Ekambaram Chitra , Padmaja Mididoddi 
Published: September 2022

AbstractNowadays, the development of e‐health monitoring devices is getting more demand for remote health applications. In addition, cardiovascular diseases is considered the most chronic disease in recent years. So, this requires a fast diagnosis and therapy to clear this issue and requires an information transformation from the patient to the distant hospital. But, it faces many challenges like more energy consumption, data security, storage, and transmission. In addition, the electrocardiogram (ECG) data must be processed in real‐time, and the information must have high predictability and lossless compression. So, in this article, an enhanced set partitioning in hierarchical tree decoder with deep belief neural network is developed for ECG compression. Due to an inappropriate channel in telemedicine applications, the ECG signals transmitted through a wireless network are affected by noise. So, fast normalized least mean square (FNLMS) algorithm based adaptive filter is deliberated to eliminate the unwanted noise from the ECG signal. Also, the structure of the FNLMs based adaptive filter is modified by developing a systolic structure to increase the speed of filtering process. Moreover, the parallel and pipelined architecture is provided for the proposed compression unit to reduce the processing time and the area overhead as compared to the existing methods. A publicly available database called the MIT‐BIH database and real‐time ECG data records are used for simulation purposes. The proposed design was implemented on the Xilinx platform and the MATLAB tool. The performance of the proposed design is estimated by the parameters like compression ratio, signal to noise ratio, root mean square error, and percentage root mean square difference (PRD), PRD normalized, and quality‐score. It is compared with existing designs to show the efficiency of our proposed design.
A statistical approach to study the spatial heavy metal distribution in soils in the Kushk Mine, Iran
Authors: Sohrabizadeh Zahra , Sodaeizadeh Hamid , Hakimzadeh Mohammad Ali , Taghizadeh‐Mehrjardi Ruhollah , Ghanei Bafghi Mohammad Javad 
Published: September 2022

AbstractThe present study was conducted for the spatial distribution and concentration evaluation of heavy metals, including Cu, Cd, Mn, Fe, Zn, and Pb, within 102 soil samples collected from Kushk Mine in Bafgh, Iran. This work employed hierarchical clustering analysis (HCA), principal component analysis (PCA), and spatial distribution patterns, to perform element distribution evaluation within the area. The distributions of heavy metals in the entire area were exhibited in the form of maps. The average concentrations of Cd, Cu, Mn, Fe, Zn, and Pb were found to be 0.39, 0.26, 5.3, 4.1, 51.9, and 40.9 mg.kg−1, respectively. Based on the PCA and HCA findings, the heavy metals were divided into two groups. The first group included Pb, Cd, Zn, and Cu. In the first group, altered threshold‐surpassing anthropogenic and lithogenic pollution was found to be the main factor accounting for Pb and Zn. The second group involved Fe and Mn, which could be impacted by either anthropogenic and lithogenic factors. Furthermore, the geo‐statistical results demonstrated higher contents of the heavy metals in the south of the mine and in the vicinity of the mine tailings. It may be concluded from the results that the heavy metal contents of the area are impacted by anthropogenic and lithogenic factors.
Survival outcomes of metastatic breast cancer patients by germline BRCA1/2 status in a large multicenter real‐world database
Authors: Mailliez Audrey , D'Hondt Veronique , Lusque Amelie , Caron Olivier , Cabel Luc , Goncalves Anthony , Debled Marc , Gladieff Laurence , Ferrero Jean‐Marc , Petit Thierry , Mouret‐Reynier Marie Ange , Eymard Jean‐Christophe , Levy Christelle , Uwer Lionel , Leheurteur Marianne , Desmoulins Isabelle , Bachelot Thomas , Frenel Jean‐Sebastien , de la Motte Rouge Thibault , Simon Gaëtane , Jacot William , Delaloge Suzette 
Published: September 2022

AbstractThe outcomes and best treatment strategies for germline BRCA1/2 mutation (gBRCAm) carriers with metastatic breast cancer (MBC) remain uncertain. We compared the overall survival and the first line progression free survival (PFS1) of patients with a gBRCAm identified at initiation of first‐line treatment with those of BRCA wild‐type (WT) and not‐tested (NT) individuals in the ESME real‐world database of MBC patients between 2008 and 2016 (NCT03275311). Among the 20 624 eligible patients, 325 had a gBRCAm, 1138 were WT and 19 161 NT. Compared with WT, gBRCAm carriers were younger, and had more aggressive diseases. At a median follow‐up of 50.5 months, median OS was 30.6 (95%CI: 21.9‐34.3), 35.8 (95%CI: 32.2‐37.8) and 39.3 months (95% CI: 38.3‐40.3) in the gBRCAm, WT and NT subgroups, respectively. Median PFS1 was 7.9 (95%CI: 6.6‐9.3), 7.8 (95%CI: 7.3‐8.5) and 9.7 months (95%CI, 9.5‐10.0). In the multivariable analysis conducted in the whole cohort, gBRCAm status had however no independent prognostic impact on OS and PFS1. Though, in the triple‐negative subgroup, gBRCAm patients had better OS and PFS1 (HR vs WT = 0.76; 95%CI: 0.60‐0.97; P = .027 and 0.69; 95% CI: 0.55‐0.86; P = .001, respectively). In contrast, in patients with HR+/HER2 negative cancers, PFS1 appeared significantly and OS non significantly lower for gBRCAm carriers (PFS1: HR vs WT = 1.23; 95%CI: 1.03‐1.46; P = .024; OS:HR = 1.22, 95% CI: 0.97‐1.52, P = .089). In conclusion, gBRCA1/2 status appears to have divergent survival effects in MBC according to IHC subtype.
ATM c.7570G>C is a high‐risk allele for breast cancer
Authors: Kankuri‐Tammilehto Minna , Tervasmäki Anna , Kraatari‐Tiri Minna , Rahikkala Elisa , Pylkäs Katri , Kuismin Outi 
Published: September 2022

AbstractATM is generally described as a moderate‐risk breast cancer susceptibility gene. However, some of ATM variants might encounter higher risk. ATM c.7570G>C, p.Ala2524Pro, (rs769142993) is a pathogenic Finnish founder variant causative for recessively inherited ataxia‐telangiectasia. At cellular level, it has been reported to have a dominant‐negative effect. ATM c.7570G>C has recurrently been described in Finnish breast cancer families and unselected case cohorts collected from different parts of the country, but the rarity of the allele (MAF 0.0002772 in Finns) and lack of confirming segregation analyses have prevented any conclusive risk estimates. Here, we describe seven families from genetic counseling units with ATM c.7570G>C variant showing co‐segregation with breast cancer. Further analysis of the unselected breast cancer cohort from Northern Finland (n = 1822), a geographical region previously indicated to have enrichment of the variant, demonstrated that c.7570G>C significantly associates with breast cancer, and the risk is estimated as high (odds ratio [OR] = 8.5, 95% confidence interval [CI] = 1.04‐62.46, P = .018). Altogether, these results place ATM c.7570G>C variant among the high‐risk alleles for breast cancer, which should be taken into consideration in genetic counseling.
Management of Hypoparathyroidism
Authors: Khan Aliya A. , Guyatt Gordon , Ali Dalal S. , Bilezikian John P. , Collins Michael T. , Dandurand Karel , Mannstadt Michael , Murphy Deborah , M'Hiri Iman , Rubin Mishaela R. , Sanders Robert , Shrayyef Muhammad , Siggelkow Heide , Tabacco Gaia , Tay Yu-Kwang Donovan , Van Uum Stan , Vokes Tamara , Winer Karen K. , Yao Liang , Rejnmark Lars 
Published: September 2022

ABSTRACT
Hypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the presence of a low or inappropriately normal parathyroid hormone level. HypoPT is most commonly seen after neck surgery, which accounts for approximately 75% of cases, whereas approximately 25% have HypoPT due to nonsurgical causes. In both groups of patients, conventional therapy includes calcium and active vitamin D analogue therapy aiming to maintain serum calcium concentration in the low normal or just below the normal reference range and normalize serum phosphorus, magnesium concentrations, and urine calcium levels. The limitations of conventional therapy include wide fluctuations in serum calcium, high pill burden, poor quality of life, and renal complications. Parathyroid hormone (PTH) replacement therapy may improve the biochemical profile in those in whom conventional therapy proves unsatisfactory. Based on a systematic review and meta-analysis of the literature, the panel made a graded recommendation suggesting conventional therapy as first line therapy rather than administration of PTH (weak recommendation, low quality evidence). When conventional therapy is deemed unsatisfactory, the panel considers use of PTH. Because pregnancy and lactation are associated with changes in calcium homeostasis, close monitoring is required during these periods with appropriate adjustment of calcium and active vitamin D analogue therapy to ensure that serum calcium remains in the mid to low normal reference range in order to avoid maternal and fetal complications. Emerging therapies include molecules with prolonged PTH action as well as different mechanisms of action that may significantly enhance drug efficacy and safety. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Corynoline protects against zearalenone‐induced liver injury by activating the SIRT1/Nrf2 signaling pathway
Authors: Sun Liqun , He Dan , Liu Yuhuan , Wei Yunyun , Wang Li 
Published: September 2022

AbstractCorynoline has been reported to have anti‐inflammatory and antioxidative effects. In the present study, the potential protective effects of corynoline against zearalenone (ZEA)‐induced liver injury were investigated. ZEA was administered daily for 5 days. Then, liver tissues were used for subsequent experiments. Corynoline attenuated liver histopathological changes induced by ZEA. The production of tumor necrosis factor‐α and interleukin‐1β in liver tissues, as well as aspartate aminotransferase and alanine aminotransferase in serum, was also inhibited by corynoline. Meanwhile, ZEA‐induced MPO activity and MDA content were both attenuated by corynoline. ZEA‐induced NF‐κB p65 and IκBα phosphorylation were inhibited by corynoline. Furthermore, SIRT1, Nrf2, and HO‐1 expression were increased by corynoline. In addition, the protective effects of corynoline against liver injury were reversed by the SIRT1 inhibitor EX‐527. Taken together, corynoline protected against ZEA‐induced liver injury by activating the SIRT1/Nrf2 signaling pathway.
Hsa_circ_0002082 up‐regulates Centromere Protein F via abolishing miR‐508‐3p to promote breast cancer progression
Authors: Liu Yu , Liu Yun , Luo Jinyong , Zhao Wen , Hu Chunhui , Chen Gongquan 
Published: September 2022

AbstractBackgroundCircular RNAs (circRNAs) dysregulation has been revealed to function in the pathological processes of cancers. Herein, the role and mechanisms of hsa_circ_0002082 in breast cancer (BC) progression were elucidated.MethodsIn vivo and in vitro functional experiments were conducted, and the interaction between miR‐508‐3p and hsa_circ_0002082 or Centromere Protein F (CENPF) was elucidated.ResultsHsa_circ_0002082 expression was higher in BC tissues and cell lines. Functionally, knockdown of hsa_circ_0002082 induced apoptosis and suppressed proliferation and metastasis in BC cells in vitro. Mechanistically, hsa_circ_0002082 targeted miR‐508‐3p, which was confirmed to be decreased in BC. MiR‐508‐3p overexpression suppressed BC cell malignant phenotypes, moreover, inhibition of miR‐508‐3p attenuated the anticancer action of hsa_circ_0002082 silencing on BC cells. Besides that, miR‐508‐3p targeted CENPF, CENPF was highly expressed in BC, CENPF up‐regulation reversed the suppressive impacts of miR‐508‐3p on BC cell growth and metastasis. Besides, hsa_circ_0002082 silencing impeded BC growth in nude mice.ConclusionKnockdown of hsa_circ_0002082 suppresses breast cancer growth and metastasis by miR‐508‐3p/CENPF axis, suggesting that hsa_circ_0002082 may be a promising target for breast cancer treatment.
Electrochemically induced assembling of isatins, kojic acid, and malonic acid derivatives into substituted spiro[indole‐3,4′‐pyran]‐2(1H)‐one scaffold and predicting potential protein targets
Authors: Elinson Michail N. , Ryzhkova Yuliya E. , Vereshchagin Anatoly N. , Ryzhkov Fedor V. , Kalashnikova Varvara M. , Korolev Viktor A. , Egorov Mikhail P. 
Published: September 2022

AbstractElectrochemically induced multicomponent assembling of isatins, kojic acid, and malonic acid derivatives in n‐propanol in the presence of sodium iodide as an electrolyte in an undivided cell results in the formation of unsymmetrical spiro(indole‐3,4′‐pyrano[3,2‐b]pyranes) in 86–98% yields. The optimized reaction conditions and a mechanistic rationale for this catalytic electrochemical transformation are presented. This new electrocatalytic multicomponent process is a facile and efficient environmentally benign way to the functionalized unsymmetrical spiro(indole‐3,4′‐pyrano[3,2‐b]pyranes), containing inserted kojic acid fragment, which are perspective compounds for different biomedical applications, among them anticonvulsant, anti‐cancer, anti‐AIDS agents, and anti‐inflammatory remedies. All synthesized compounds were investigated using a molecular docking procedure. The results of prediction were incorporated in one pool of potential targets. The automated method was proposed and performed for the docking procedure. It is distinct from screening by higher accuracy, and it is much more scalable than the classic docking procedure. It was found that the synthesized compounds are potential ligands for 4OHK (glucokinase regulatory protein) and 3V2B (human poly[adp‐ribose] polymerase 15) proteins.
Four‐stage CMOS operational transconductance amplifier: Compensated via double differential blocks
Authors: Roohbakhsh Danial , Sanaee AliMohammad , Aghaee Toktam 
Published: September 2022

AbstractAdvancements in integrated circuits technology, force designers to adopt methods and approaches with posed limitations. Nowadays, multistage amplifiers are widely in demand due to high‐gain performance while avoiding placing transistors vertically in contrast with cascode structures. In this work, a four‐stage amplifier is investigated and frequency is compensated via a compensation network that includes two Miller capacitors at the outputs of differential blocks. So, using two Miller capacitors and sharing these capacitors common in four Miller loops, provide an opportunity to achieve acceptable frequency response regarding gain‐bandwidth product and phase margin. The proposed amplifier is modeled symbolically and simulated with the HSPICE circuit simulator with the help of 0.18 μm CMOS technology. According to the simulation results, the proposed approaches show superior performance compared with previously existing methods. Additionally, the sensitivity of the proposed amplifier against load and compensation capacitors expresses a stable and relatively fixed frequency response. Such a high gain amplifier with more than 180 dB as DC gain and 88° phase margin, is in great demand for realizing modulators and data converters.
Long noncoding RNA CDKN2B‐AS1 silencing protects against esophageal cancer cell invasion and migration by inactivating the TFAP2A/FSCN1 axis
Authors: Zhu Jia‐Liang , Xue Wen‐Bo , Jiang Zhi‐Bin , Feng Wei , Liu Yi‐Cai , Nie Xiong‐Ying , Jin Long‐Yu 
Published: September 2022

AbstractEsophageal cancer (EC) is the most aggressive malignancy in the gastrointestinal tract. Long noncoding RNA cyclin‐dependent kinase inhibitor 2 B antisense RNA 1 (CDKN2B‐AS1) is implicated in EC development. However, the specific mechanisms involved remain poorly defined. Therefore, this research aimed to explore the mechanism of action of CDKN2B‐AS1 in EC. Quantitative real‐time polymerase chain reaction was conducted to measure CDKN2B‐AS1 expression in EC cells and western blotting was utilized to evaluate transcription factor AP‐2 alpha (TFAP2A) and fascin actin‐bundling protein 1 (FSCN1) expression. After gain‐of‐function and loss‐of‐function assays, cell proliferation, migration, invasion, apoptosis, and apoptosis‐related protein expression were assessed using cell counting kit‐8, scratch tests, Transwell assays, flow cytometry, and western blotting, respectively. The binding relationship between CDKN2B‐AS1 and TFAP2A was assessed by RNA immunoprecipitation and RNA pull‐down assays. The binding relationship between TFAP2A and FSCN1 was evaluated using dual‐luciferase reporter and chromatin immunoprecipitation assays. Tumor xenografts from nude mice were used for in vivo verification. CDKN2B‐AS1, TFAP2A, and FSCN1 were upregulated in EC cells. Mechanistically, CDKN2B‐AS1 transcriptionally activated FSCN1 by recruiting TFAP2A to the FSCN1 promoter. Silencing CDKN2B‐AS1 or TFAP2A suppressed EC cell proliferative, migrating, and invasive properties and augmented apoptosis. TFAP2A was bound to CDKN2B‐AS1 and the FSCN1 promoter. Overexpression of TFAP2A or FSCN1 abolished the effects of CDKN2B‐AS1‐silencing on EC cell function. CDKN2B‐AS1 silencing curtailed tumorigenesis in nude mice, which was nullified by the upregulation of TFAP2A or FSCN1. Our findings demonstrated the antioncogenic effects of silencing CDKN2B‐AS1 in EC through inactivation of the TFAP2A/FSCN1 axis.
Changes within the roadbed and the cutslope of an abandoned forest road—A case‐study from the Tatra Mts. (Poland)
Authors: Fidelus‐Orzechowska Joanna , Puniach Edyta , Ćwiąkała Paweł , Strzyżowski Dariusz , Nędzka Michał 
Published: September 2022

AbstractThe main aim of this paper was to determine the rate of erosion and aggradation within a forest road on different geological structures as well as a comparison of changes between roadbeds and road cutslopes. The research was conducted in the Lejowa Valley in the Tatra Mountains. The measurements of the forest road were performed using a Leica ScanStation C10 terrestrial laser scanner (TLS) with a set of six‐inch Leica High Definition Survey (HDS) targets. Based on the multi‐temporal digital elevation models (DEMs) two DEM of Differences (DoD) were created for the summer season of 2019 and the 2019–2020 period. The research has shown that there is a significant difference between the rate of relief change for roads constructed atop conglomerates and limestone. The net change for the road within conglomerates was an erosion of 432.37 m3ha‐1 yr‐1, while for the road within limestone it was a sediment deposition which amounted to 3.87 m3ha‐1 yr‐1. Research has shown that there exists a difference in the rate of erosion for road cutslopes and roadbeds constructed within conglomerates. It was shown that the erosion rate for the roadbeds was 1.7‐times larger than that for the studied road cutslopes in the period 2019–2020. Improperly designed and constructed forest roads may be subject to intensive relief transformations, even after they are no longer in use.
Evolutionary game analysis on behavioral strategies of four participants in green technology innovation system
Authors: Liu Li , Wang Zhe , Song Zhao , Zhang Zaisheng 
Published: September 2022

AbstractTo study the sustainable development of the green technology innovation system (GTIS), more and more people have begun to pay attention to the behavior evolution and strategic choice of participants. This paper develops a four‐participant evolutionary game model to study the interaction and behavior evolution of government, financial institutions, enterprises, and the public on green technology innovation (GTI), determines the payoff matrix of GTIS, derives replicator dynamic equations, calculates evolutionary stability strategies (ESSs) of participants, and identifies evolution paths of ESSs through numerical simulations. The findings show that in most cases, the government prefers to adopt “weak supervision” strategies to regulate the market, and the public prefers to adopt “supervision” strategies to supervise enterprises. Encouraging enterprises to implement GTI through subsidies and funding support is a vital means in the initial stage of sustainable development. It is imperative to establish a multi‐participant collaborative governance mechanism to promote the sustained and sound GTIS development.
Integrated identification of growth pattern and taxon of bacterium in gut microbiota via confocal fluorescence imaging‐oriented single‐cell sequencing
Authors: Gao Juan , Sun Di , Li Bei , Yang Chaoyong , Wang Wei 
Published: September 2022

AbstractDespite the fast progress in our understanding of the complex functions of gut microbiota, it is still challenging to directly investigate the in vivo microbial activities and processes on an individual cell basis. To gain knowledge of the indigenous growth/division patterns of the diverse mouse gut bacteria with a relatively high throughput, here, we propose an integrative strategy, which combines the use of fluorescent probe labeling, confocal imaging with single‐cell sorting, and sequencing. Mouse gut bacteria sequentially labeled by two fluorescent d‐amino acid probes in vivo were first imaged by confocal microscopy to visualize their growth patterns, which can be unveiled by the distribution of the two fluorescence signals on each bacterium. Bacterial cells of interest on the imaging slide were then sorted using a laser ejection equipment, and the collected cells were then sequenced individually to identify their taxa. Our strategy allows integrated acquirement of the growth pattern knowledge of a variety of gut bacteria and their genomic information on a single‐cell basis, which should also have great potential in studying many other complex bacterial systems.
Elliptical cylindrical equivalent model for consolidation of unsaturated soil improved by PVD
Authors: Tian Yi , Jiang Guosheng , Wu Wenbing , Wen Minjie , El Naggar M. Hesham , Mei Guoxiong 
Published: September 2022

AbstractTo consider the shape effect of prefabricated vertical drain (PVD), the elliptical cylindrical equivalent model (ECEM) is established for the consolidation of unsaturated soft foundations improved by PVD. Then, the associated analytical solutions of excess pore‐air and pore‐water pressures are derived under free strain and equal strain conditions, respectively. The rationality of proposed solutions is verified by comparing them with the existing solutions. Through conducting the parametric study, the effects of the permeability coefficients and the extent of influence zone on the dissipation of excess pore pressure and the consolidation settlement are investigated. Outcomes show that there is a plateau during the dissipation process of the excess pore‐water pressure. The consolidation behavior is dominated by the dissipation of the excess pore‐air pressure before the plateau, while it is governed only by the dissipation of the excess pore‐water pressure after the plateau.