bluuebunny/crossref_metadata_2025_split huggingface dataset:
On-Schedule Mammography Rescreening in the National Breast and Cervical Cancer Early Detection Program
Authors: Bobo Janet Kay , Shapiro Jean A. , Schulman Jane , Wolters Charles L. 
Published: June 2022

Abstract
Objective: The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) provides free cancer screening to many low-income, underinsured women annually but does not routinely collect all data necessary for precise estimation of mammography rescreening rates among enrollees. Materials and Methods: To determine the percentages rescreened and to identify factors that encourage on-schedule rescreening, telephone interview and medical record data were collected from 1685 enrollees in Maryland, New York, Ohio, and Texas at least 30 months after their 1997 index mammogram. Results: Overall, 72.4% [95% confidence interval (95% CI) = 70.1–74.7] were rescreened within 18 months and 81.5% (95% CI = 79.6–83.5) within 30 months. At 30 months, the adjusted odds ratios (ORs) for rescreening were higher among Hispanics (OR = 1.95, 95% CI = 1.15–3.28), women with a history of breast cancer before the index mammogram (OR = 3.36, 95% CI = 1.07–10.53), and those who had used hormone replacement therapy before their index mammogram (OR =1.94, 95% CI = 1.30–2.91). The 30-month adjusted ORs were lower for women who reported poor health status (OR = 0.60, 95% CI = 0.42–0.85), did not have a usual source of care (OR = 0.61, 95% CI = 0.40–0.94), did not know if they could have another free mammogram (OR = 0.28, 95% CI = 0.14–0.51), described their index screen as their first mammogram ever (OR for no prior mammograms versus three or more = 0.40, 95% CI = 0.27–0.60), did not recall receiving a rescreening reminder (OR = 0.35, 95% CI = 0.25–0.48), or did not think they had been encouraged to rescreen by their provider (OR = 0.61, 95% CI = 0.44–0.86). Discussion: Rescreening behavior in this sample of NBCCEDP enrollees was comparable with that observed in other populations. To facilitate routine rescreening among low-income women, ongoing efforts are needed to ensure they receive annual reminders and encouragements from their medical providers and that they know how to obtain the services they need.
Soy Isoflavones Do Not Modulate Prostate-Specific Antigen Concentrations in Older Men in a Randomized Controlled Trial
Authors: Adams Kenneth F. , Chen Chu , Newton Katherine M. , Potter John D. , Lampe Johanna W. 
Published: June 2022

Abstract
Mortality rates for prostate cancer are low in Asia but high in the West. One explanation is the high level of soy consumption in Asia. Soy isoflavones reduce prostate tumor growth in many, but not all, animal models. Elevated levels of serum prostate-specific antigen (PSA) are a marker of prostate tumor growth. Our objective was to determine whether 12-month soy isoflavone supplementation would alter serum PSA concentrations in healthy, older men. The parent study was a double-blinded, parallel-arm, randomized trial in which participants were assigned to consume either a soy protein drink providing 83 mg/day isoflavones (+ISO) or a similar drink with isoflavones removed (−ISO). Participants in the parent study were 85% men. Of the 128 men enrolled in the trial, 112 completed. These men were later contacted for consent to allow their stored sera to be analyzed for PSA and 81 men consented. We measured PSA in serum collected at 0 and 12 months using a commercial radioimmunometric assay. Serum PSA concentrations increased in both groups over the 12-month intervention, but the changes were similar: Geometric mean PSA concentration increased 0.5% more in the +ISO group than in the −ISO group (P = 0.94; 95% confidence interval = −17.3 to 22.2). The proportion of participants having a serum PSA velocity greater than 1 ng/ml/year was similar in the +ISO and −ISO groups (17.6% versus 12.8%; P = 0.54). We found no evidence that a 12-month 83 mg/day isoflavone treatment alters serum PSA concentration or velocity in seemingly healthy men aged 50–80 years.
Effects of a Moderate Intensity Exercise Intervention on Estrogen Metabolism in Postmenopausal Women
Authors: Atkinson Charlotte , Lampe Johanna W. , Tworoger Shelley S. , Ulrich Cornelia M. , Bowen Deborah , Irwin Melinda L. , Schwartz Robert S. , Rajan Bharat K. , Yasui Yutaka , Potter John D. , McTiernan Anne 
Published: June 2022

Abstract
Physical activity has been associated with reduced breast cancer risk, potentially via hormonal pathways, and high urinary excretion of 2-hydroxyestrone (2-OH E1) relative to 16α-hydroxyestrone (16α-OH E1) also has been associated with reduced breast cancer risk. Studies suggest that body composition and exercise can influence estrogen metabolism. We determined the effects of a 12-month moderate intensity aerobic exercise intervention on urinary 2-OH E1, 16α-OH E1, and their ratio in overweight and obese, previously sedentary, postmenopausal women, ages 50–75 years. Women were randomized to a 12-month exercise intervention (n = 87) or stretching control group (n = 86); 170 completed the study. Urinary 2- and 16α-OH E1 were measured in spot urines collected at baseline, 3, and 12 months. Body composition was measured at baseline and 12 months. Differences between exercisers and controls for excretion of estrogen metabolites were determined using general estimating equations. Further analyses assessed change in estrogen metabolites and their ratio by subgroups of change in body composition. Overall, there were no significant effects of the exercise intervention on 2-OH E1, 16α-OH E1, or their ratio (P &gt; 0.05). There appeared to be an effect of change in intra-abdominal fat and adherence to the exercise intervention on change in the estrogen metabolites or their ratio. However, this did not reflect a potentially desirable change in estrogen metabolites associated with the exercise intervention. Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E1, 16α-OH E1, or their ratio in this population of women.
Using Nuclear Morphometry to Discriminate the Tumorigenic Potential of Cells: A Comparison of Statistical Methods
Authors: Wolfe Pamela , Murphy James , McGinley John , Zhu Zongjian , Jiang Weiqin , Gottschall E. Brigitte , Thompson Henry J. 
Published: June 2022

Abstract
Despite interest in the use of nuclear morphometry for cancer diagnosis and prognosis as well as to monitor changes in cancer risk, no generally accepted statistical method has emerged for the analysis of these data. To evaluate different statistical approaches, Feulgen-stained nuclei from a human lung epithelial cell line, BEAS-2B, and a human lung adenocarcinoma (non-small cell) cancer cell line, NCI-H522, were subjected to morphometric analysis using a CAS-200 imaging system. The morphometric characteristics of these two cell lines differed significantly. Therefore, we proceeded to address the question of which statistical approach was most effective in classifying individual cells into the cell lines from which they were derived. The statistical techniques evaluated ranged from simple, traditional, parametric approaches to newer machine learning techniques. The multivariate techniques were compared based on a systematic cross-validation approach using 10 fixed partitions of the data to compute the misclassification rate for each method. For comparisons across cell lines at the level of each morphometric feature, we found little to distinguish nonparametric from parametric approaches. Among the linear models applied, logistic regression had the highest percentage of correct classifications; among the nonlinear and nonparametric methods applied, the Classification and Regression Trees model provided the highest percentage of correct classifications. Classification and Regression Trees has appealing characteristics: there are no assumptions about the distribution of the variables to be used, there is no need to specify which interactions to test, and there is no difficulty in handling complex, high-dimensional data sets containing mixed data types.
Challenges Predicting the Cardiovascular Future for Survivors of Childhood Cancer
Authors: Mulrooney Daniel A. 
Published: June 2022

Abstract
Cardiovascular disease (CVD) risk stratification relies on assessment of nonmodifiable (age, sex, family history) and modifiable (weight, tobacco, physical activity, blood pressure, glucose/lipid levels) risk factors. Cancer therapy, itself a potential risk factor, may alter metabolism in long-term survivors of childhood cancer resulting in premature acquisition of age-related modifiable CVD risk factors. For survivors exposed to cardiotoxic therapies, the risk for CVD is significantly augmented by obesity, diabetes, dyslipidemia, and hypertension. An understanding of these risks may not be well communicated as survivors return to primary care and general population screening practices may be insufficient. Lipshultz and colleagues recruited childhood cancer survivors to return to their treating institution for a comprehensive clinical assessment. Interestingly, compared with a noncancer age-, sex-, and race/ethnicity-matched National Health and Nutrition Examination Survey population, cardiometabolic profiles were largely similar. However, cancer survivors had a higher prevalence of prehypertension/hypertension (38.4% vs. 30.1%, P = 0.04) and a lower prevalence of the metabolic syndrome (11.9% vs. 18.7%, P = 0.05). Applying general population CVD risk calculators and a cancer-specific model from the Childhood Cancer Survivor Study, risk estimates were notably higher when cardiotoxic cancer treatment exposures were included.
See related article by Lipshultz et al., p. 536
The Right to Privacy in the Digital Age as Expressed in a Muslim Country: A Case Study of Kuwait
Authors: al-Mutairi Noura H. 
Published: June 2022

Abstract
This article is primarily concerned with setting a definition for the right to privacy in the digital age, which reflects its meaning and social value in Kuwait as an Arab — Muslim country. While ‘ḥurmah’ is considered as equivalent to ‘privacy’, under the primary sources of Islamic law, its meanings do not provide a sufficient explanation of what is meant by privacy. Also, most Arabic academics, instead of focusing on the illustration of privacy from the perspective of Islamic law, have tended to demonstrate the term ‘privacy’ according to Western theories, without considering the differences between Western and Islamic cultures and the value of that right in each. As such, this article has illustrated and explained the prevalent Western theories, but with reflection from the perspective of Islamic law, in order to set a definition for that right which reflects its meaning and social value in Kuwait as a Muslim country.
Outcry over The Second Sex
Authors: Chaperon Sylvie , Millman Sophia 
Published: June 2022

Abstract
This article explores the critical reception of The Second Sex in France in 1949. Situating debates about the book in the context of the Cold War and the intellectual hegemony of existentialism, the author analyzes the main points of disagreement among different political factions—traditional Catholics, communists, members of the noncommunist left, and progressive Christians. She argues that the sexual questions Simone de Beauvoir raised in the public sphere fueled the primary points of contention.
spatialLIBD: an R/Bioconductor package to visualize spatially-resolved transcriptomics data
Authors: Pardo Brenda , Spangler Abby , Weber Lukas M. , Page Stephanie C. , Hicks Stephanie C. , Jaffe Andrew E. , Martinowich Keri , Maynard Kristen R. , Collado-Torres Leonardo 
Published: June 2022

Abstract
Background
Spatially-resolved transcriptomics has now enabled the quantification of high-throughput and transcriptome-wide gene expression in intact tissue while also retaining the spatial coordinates. Incorporating the precise spatial mapping of gene activity advances our understanding of intact tissue-specific biological processes. In order to interpret these novel spatial data types, interactive visualization tools are necessary.

Results
We describe spatialLIBD, an R/Bioconductor package to interactively explore spatially-resolved transcriptomics data generated with the 10x Genomics Visium platform. The package contains functions to interactively access, visualize, and inspect the observed spatial gene expression data and data-driven clusters identified with supervised or unsupervised analyses, either on the user’s computer or through a web application.

Conclusions
spatialLIBD is available at https://bioconductor.org/packages/spatialLIBD. It is fully compatible with SpatialExperiment and the Bioconductor ecosystem. Its functionality facilitates analyzing and interactively exploring spatially-resolved data from the Visium platform.
In Vitro Generation of BK polyomavirus-specific T cells for adoptive cell therapy in refractory cystitis hemorrhagic patients after hematopoietic stem cell transplantation
Authors: Najafabadi Maryam Mohammadi , Soleimani Masoud , Ahmadvand Mohammad , Zomorrod Mina Soufi , Mousavi Seied Asadollah 
Published: June 2022

Abstract
Introduction
BKPyV associated hemorrhagic cystitis (BKPyV-HC) is a major and prevalent outcome of hematopoietic stem cell transplantation (HSCT) with no standard treatment option. Adoptive T cell therapy (ACT) against transplant-associated viruses has shown promising potential. We sought to produce virus-specific T cells (VSTs) against BKPyV with the aim of treating refractory HSCT-associated HC.

Methods
Peripheral blood mononuclear cells (PBMC) from healthy donors were isolated by Ficoll-Hypaque density gradient centrifugation. BKPyV-pulsed, monocyte-derived dendritic cells (mo-DCs) and T cells were co-cultured and expanded over 2–3 weeks with the addition of IL-2. The T cells were examined for various functional assays.

Results
Comparison analysis of Carboxyfluorescein diacetate succinimidyl ester (CFSE) indicated that the percentage of proliferated cells were significantly higher in donors (49.62 ± 7.09%) than controls (7.96 ± 4.55%). Furthermore, expanded T cells exhibited specificity to BKPyV antigens by IFN-γ ELISPOT assay. The expanded cells showed cytotoxic function versus human lymphoblastoid cell line (LCL). Final VST products mainly comprised of CD8/CD69 double-positive T cells, which were significantly higher in donors (46.8 ± 7.1%) than controls (16.91 ± 3.40%).

Conclusion
In this study we demonstrated the feasibility of producing functional BKPyV-specific T cells in healthy donors using BKPyV PepMixes. These functional cells were able to proliferate and produce IFN-γ cytokine in response to BKPyV PepMixes. In addition, these T cells had cytotoxic ability against BKPyV antigen-expressing target cells.
Novel γδ T cell-based prognostic signature to estimate risk and aid therapy in hepatocellular carcinoma
Authors: Wang Jingrui , Ling Sunbin , Ni Jie , Wan Yafeng 
Published: June 2022

Abstract
Background
Numerous studies have revealed that gamma delta (γδ) T cell infiltration plays a crucial regulatory role in hepatocellular carcinoma (HCC) development. Nonetheless, a comprehensive analysis of γδ T cell infiltration in prognosis evaluation and therapeutic prediction remains unclear.

Methods
Multi-omic data on HCC patients were obtained from public databases. The CIBERSORT algorithm was applied to decipher the tumor immune microenvironment (TIME) of HCC. Weighted gene co-expression network analysis (WGCNA) was performed to determine significant modules with γδ T cell-specific genes. Kaplan-Meier survival curves and receiver operating characteristic analyses were used to validate prognostic capability. Additionally, the potential role of RFESD inhibition by si-RFESD in vitro was investigated using EdU and CCK-8 assays.

Results
A total of 16,421 genes from 746 HCC samples (616 cancer and 130 normal) were identified based on three distinct cohorts. Using WGCNA, candidate modules (brown) with 1755 significant corresponding genes were extracted as γδ T cell-specific genes. Next, a novel risk signature consisting of 11 hub genes was constructed using multiple bioinformatic analyses, which presented great prognosis prediction reliability. The risk score exhibited a significant correlation with ICI and chemotherapeutic targets. HCC samples with different risks experienced diverse signalling pathway activities. The possible interaction of risk score with tumor mutation burden (TMB) was further analyzed. Subsequently, the potential functions of the RFESD gene were explored in HCC, and knockdown of RFESD inhibited cell proliferation in HCC cells. Finally, a robust prognostic risk-clinical nomogram was developed and validated to quantify clinical outcomes.

Conclusions
Collectively, comprehensive analyses focusing on γδ T cell patterns will provide insights into prognosis prediction, the mechanisms of immune infiltration, and advanced therapy strategies in HCC.
Impulsive Lifestyle Counselling versus treatment as usual to reduce offending in people with co-occurring antisocial personality disorder and substance use disorder: a post hoc analysis
Authors: Hesse Morten , del Palacio-Gonzalez Adriana , Thylstrup Birgitte 
Published: June 2022

AbstractObjectivesTo assess the impact of a short psychoeducation intervention for antisocial personality disorder on offending after randomization to treatment.DesignMulticentre, superiority, non-blinded randomized controlled trial. Random assignment was conducted in blocks of varying sizes at a central randomization centre. Participants were followed using national register data until 365 days after randomization, migration, or death, whichever occurred first.SettingThirteen outpatient uptake areas in Denmark.ParticipantsPatients with antisocial personality disorder in treatment for substance use disorders were randomized to treatment as usual (TAU,n = 80) or Impulsive Lifestyle Counselling (ILC,n = 96). A total of 165 patients could be linked to criminal records (TAU,n = 74; ILC,n = 91).InterventionILC is a brief psychoeducational program targeting antisocial behavior. The trial was conducted between January 2012 and June 2014.OutcomesNumber of criminal offences leading to convictions based on national registers.ResultsThe mean number of offences was 2.76 in the TAU group (95% Poisson confidence interval [CI] = 2.39, 3.16) and 1.87 in the ILC group (95% CI = 0.97, 1.43). Negative binomial regression was used to assess total number of convictions, as well as convictions for violent, property, driving under the influence, and drug-related crimes. In both adjusted and unadjusted analyses, random assignment to ILC was associated with a lower number of total offences (incidence rate risk ratio [IRR] = 0.43,p = .013; adjusted IRR = 0.45,p < .001) and convictions related to violence (IRR = 0.19,p = .001 adjusted IRR = 0.19,p = .007) and property offences (unadjusted IRR = 0.30,p = 0.003, adjusted IRR = 0.42,p = 0.010). Differences between conditions were not significant for driving under the influence (unadjusted IRR = 0.49,p = .370; adjusted IRR = 0.53,p = .417) or drug offences (unadjusted IRR = 1.06,p = .907; adjusted IRR = 0.55,p = .223).ConclusionsThe ILC program shows promise in reducing offending behavior in people with comorbid substance use and antisocial personality disorder.Trial registrationISRCTN registry,ISRCTN67266318, 15/10/2012.
Impact of the ‘Healthy Youngsters, Healthy Dads’ program on physical activity and other health behaviours: a randomised controlled trial involving fathers and their preschool-aged children
Authors: Morgan Philip J. , Grounds Jacqueline A. , Ashton Lee M. , Collins Clare E. , Barnes Alyce T. , Pollock Emma R. , Kennedy Stevie-Lee , Rayward Anna T. , Saunders Kristen L. , Drew Ryan J. , Young Myles D. 
Published: June 2022

Abstract
Background
Targeting fathers may be a key strategy to increase physical activity among their preschool-aged children, but limited research exists in this area. The primary study aim was to examine the impact of a lifestyle program for fathers and their preschool-aged children on child physical activity levels.

Methods
A total of 125 fathers (aged: 38 ± 5.4 years, BMI: 28.1 ± 4.9 kg/m2) and 125 preschool-aged children (aged: 3.9 ± 0.8 years, BMI z-score: 0.3 ± 0.9, 39.2% girls) recruited from Newcastle, Australia, NSW were randomised to (i) the Healthy Youngsters, Healthy Dads (HYHD) program, or (ii) wait-list control group. The program included two fathers-only workshops (2 h each) and eight father-child weekly educational and practical sessions (75 min each), plus home-based activities targeting family physical activity and nutrition. Assessments took place at baseline, 10-weeks (post-intervention) and 9-months follow-up. The primary outcome was the children’s mean steps/day at 10-weeks. Secondary outcomes included: co-physical activity, fathers’ physical activity levels and parenting practices for physical activity and screen time behaviours, children’s fundamental movement skill (FMS) proficiency, plus accelerometer based light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA), screen time and adiposity for fathers and children. Process measures included; attendance, satisfaction, fidelity and retention. Linear mixed models estimated the treatment effect at all time-points for all outcomes.

Results
Intention-to-treat analyses revealed a significant group-by-time effect for steps per day at 10-weeks (+ 1417, 95%CI: 449, 2384) and 9-months follow-up (+ 1480, 95%CI: 493, 2467) in intervention children compared to control. There were also favourable group-by-time effects for numerous secondary outcomes including fathers’ physical activity levels, children’s FMS proficiency, and several parenting constructs. No effects were observed for both fathers’ and children’s accelerometer based LPA or MVPA, co-physical activity, screen-time and adiposity measures. Process evaluation data revealed very high levels of satisfaction, attendance, retention, and intervention fidelity.

Conclusion
Engaging fathers in a lifestyle program is a promising strategy to increase physical activity among preschool-aged children. Additional benefits to fathers’ physical activity levels, children’s FMS proficiency and parenting practices further support the importance of engaging fathers to improve family health outcomes.

Trial Registration
Australian New Zealand Clinical Trials Registry: ACTRN12619000105145. Registered 24/01/2019.