bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time Between Onset of Symptoms and Definitive Treatment in Children with Acute Appendicitis
Authors: Dimopoulou Anastasia , Yfanti Amalia , Argyropoulos Theodoros , Evaggelou Eleni , Dimopoulou Dimitra , Dimopoulou Konstantina , Iakomidis Emmanouil , Feizidou Paraskevi , Zavras Nikolaos 
Published: July 2022

Purpose:
Any delay in treatment of acute appendicitis (AA) could lead to complications increasing morbidity and length of hospital stay (LHS). The aim of this study was to determine the time interval between onset of symptoms and seeking medical attention and definitive treatment in children with AA and its impact on LHS.

Materials and Methods:
A prospective study was conducted from December 2017 to March 2018. All patients diagnosed with AA and who underwent surgical procedure were enrolled. A questionnaire leaflet completed by parents was used to collect clinical data and information about seeking medical attention and children's management. Time was divided into six different intervals (1–2 h, 3–6 h, 7–12 h, 13–24 h, >24 h and >48 h) to estimate the time between onset of symptoms and seeking medical attention and time between hospital admission and surgical procedure. LHS was recorded.

Results:
During the study period, 125 children were enrolled. Over half of the patients sought for medical assistance relatively soon (3–12 h) after the onset of symptoms, whereas 17.6% sought late healthcare (>24 h). The time between the medical examination and surgical procedure was <24 h in approximately 80% of the children. LHS was affected by time between onset of symptoms and seeking medical attention and time between medical examination and surgical procedure (P = 0.001 and P = 0.017, respectively).

Conclusions:
The majority of the children with AA admitted to hospital were treated relatively soon after the onset of symptoms. However, a significant proportion of children delayed to seek medical advice and undergo appendectomy, increasing LHS.
Quality of life and its sociodemographic determinants in breast cancer patients
Authors: Surbhi  , Gupta Himanshu , Brar Gurmeet Kaur , Jalota Vineet 
Published: July 2022

ABSTRACT

Background:
Breast cancer is the most common cancer in women worldwide. As the outcome of any cancer treatment is not only dependent on disease-free interval but also on the quality of life (QOL) of the survivor. Hence, this study was conducted to evaluate QOL of breast cancer patients and sociodemographic factors affecting QOL of patients.

Subjects and Methods:
A cross-sectional study was conducted among 50 breast cancer patients and 50 controls, which fulfilled the selection criteria. The sociodemographic profile and QOL using the World Health Organization QOL-BREF were analyzed using the descriptive statistical methods.

Results:
All the QOL indicators were statistically significantly (P = 0.0001) lower among breast cancer patients. QOL indicators were statistically significantly (P < 0.01) lower in young age. Not much difference was observed according to religion and these were significantly (P < 0.05) higher among the homemakers. There was no significant difference in all the QOL indicators according to the marital status of the cases. However, these were significantly (P < 0.05) higher among rural cases compared with urban one. The QOL indicators were statistically significantly (P < 0.05) higher among the cases living in joint families than nuclear. No difference was observed among different socioeconomic status.

Conclusion:
QOL was significantly lower among the breast cancer patients. Age, occupational status, type of family, and locality were the significant factors that affect the QOL of breast cancer patients. Hence, psychological and social support can play an important role in improving QOL of cancer patient.
Clinical profile and in-hospital outcomes of COVID-19 among adolescents at a tertiary care hospital in India
Authors: Ghosh Tamoghna , Suri Tejas M. , Jat Kana R. , Gupta Aditya K. , Bhatnagar Sushma , Tiwari Pawan , Mittal Saurabh , Mohan Anant 
Published: July 2022

Introduction:
We aimed to describe the clinical profile and risk factors for severe disease in adolescents hospitalised with coronavirus disease 2019 (COVID-19)

Methods:
A retrospective analysis of an admitted cohort of COVID-19 patients was performed at a tertiary hospital in North India. Adolescents aged 12–18 years who were hospitalised during the first wave (March–December, 2020) and the second wave (March–June, 2021) were included. Data on the demographic details, clinical presentation, laboratory parameters, disease severity at admission, treatments received, and in-hospital outcomes were retrieved

Results:
The study included 197 adolescents with a median [inter-quartile range (IQR)] age of 15 (13–17) years, of whom 117 (59.4%) were male. Among these, 170 (86.3%) were admitted during the first wave. Underlying co-morbidities were present in nine (4.6%) patients. A total of 60 (30.9%) patients were asymptomatic. In the severity grading, 148 (84.6%) had mild, 16 (9.1%) had moderate, and 11 (6.3%) had severe disease. Fever (14.9%) and cough (14.9%) were the most commonly encountered symptoms. The median (IQR) duration of hospital stay was 10 (8–13) days, and six (3.1%) patients died in the hospital

Conclusion:
Adolescents admitted with COVID-19 had predominantly asymptomatic or mild disease, and the mortality rate was 3.1%.
Measurement of diffusion lung capacity (DLCO) in silicosis patients
Authors: Dixit Ramakant , Jalutharia Jitendra , Gupta Avinash , Mathur Reena , Goyal Mukesh , Gupta Neeraj , Chaudhary Pradeep , Tiwari Tarun 
Published: July 2022

Objective:
This study was conducted to evaluate diffusion capacity of lung for carbon monoxide (DLCO) in patients with simple and complicated silicosis and to correlate abnormal findings detected, if any, with the computed tomography abnormalities in these patients

Methods:
This study included 56 patients with simple and complicated silicosis and without tuberculosis, in whom we performed DLCO as per standard technique. Various computed tomography findings, that is, presence, size and distribution of nodules associated with relative parenchymal and vascular markings, were recorded in the study subjects and classified into standard grading to be finally compared with DLCO. Visual grading score system was used to describe the extent of emphysematous changes based on the area of abnormally low attenuation, vascular disruption, bullae and so on and data were recorded

Results:
Results showed that 85.7% patients had small opacities of varying grades and 28.5% showed large opacities, with 16% of them having type ‘C’ large opacities. The mean DLCO (% predicted) of patients with category ‘0’ high-resolution computed tomography (HRCT) abnormality was 92.3 ± 6.8 (within normal limits), and this gradually decreased with increasing HRCT category to 44.2 ± 11.2 in grade ‘4’ of progressive massive fibrosis (PMF) patients in this study (P < 0.01). This reflects a significant inverse correlation between visual HRCT category and the DLCO % predicted (r > −0.89, P < 0.001). The mean DLCO (% predicted) was 51 ± 12.6 in patients with grade ‘1’ emphysema in HRCT, 53 ± 13.5 in grade ‘2’, 43 ± 6.4 in grade ‘3’ and 37.7 ± 6.3 in grade ‘4’; however, there was no correlation between emphysema grading and pulmonary functional index (r = −0.33, P = 0.15)

Conclusion:
This study observed significant abnormality in DLCO among silicosis patients and its strong correlation with the extent of radiological abnormality. HRCT finding of large opacities could be an important indicator of the severity of silicosis, as reflected by significantly reduced DLCO in such patients.
Evaluation of self-reported knowledge and understanding towards a blended research course among pharmacy students: Objective Search Literature Evaluation (OSLE) method validation
Authors: Gillani Syed Wasif , Siddiqui Ammar A. , Elshafie Riham , Rathore Hassaan Anwer 
Published: July 2022

Background: The objective of the study was to evaluate the impact of classroom versus online Modular object-oriented dynamic learning environment (MOODLE)-based teaching on objective search literature evaluation (OSLE) score, as well as to validate the OSLE method for the assessment of research skills in pharmacy students.
Methods: The four-station OSLE method was used to assess the performance and self-reflection at the end of each delivery mode. The students were asked to voluntarily vote for the preference of delivery mode in research courses. A hierarchical regression analysis was performed for variables predicting the “preference” for class-based teaching and/or MOODLE-based learning. Internal face and content validation were performed with students and faculty members not involved in the course teaching. External validation was performed with three professors working in different colleges in United Arab Emirates (UAE), Saudi Arabia and Qatar.
Results: Thirty-five students completed the courses and showed significant improvement in self-reported reflection of pre-post knowledge and understanding. Findings suggested that 87.3% (110/126, 95%CI: 75.9 – 89.4, p < 0.001) achieved performance indicators and reported the OSLE method as an effective tool for the assessment of knowledge and understanding of research skills in pharmacy education. The predictive model suggested a strong positive effect associated with article appraisal, article application, self-reporting of knowledge and self-reporting of understating (R2 0.47, F-1.26, p < 0.001).
Conclusion: The findings suggested the OSLE method as an effective tool of assessment in pharmacy education. A negative impact of MOODLE-based learning was found with self-reflection on knowledge.
Elaboración de una barra alimenticia de kiwicha, polen y miel de abeja
Authors: Quevedo Rojas Tito Daniel , Gastulo Malca Juan Alexis Ricardo , Santa Cruz Abraham Guillermo Ygnacio 
Published: July 2022

El objetivo del presente trabajo fue elaborar una barra alimenticia de kiwicha, polen y miel de abeja y realizar los análisis fisicoquímicos, organolépticos y microbiológicos del producto obtenido. Se pesaron las materias primas para los 3 tratamientos, la kiwicha fue sometida a un térmico de 120ºC/20 seg., la masa se homogenizo manualmente, se colocó en una placa rectangular, previamente cubierta con papel aluminio, se llevó al horno rotatorio a una temperatura constante de 160ºC/ 15 min, el producto se enfrió a temperatura ambiente 24ºC, se desmoldo y se cortaron en barritas de 30 gramos, se empaquetó en film de polipropileno y se termo-selló. La investigación tuvo tres tratamientos en función a la miel de abeja: T1= 15%, T2=20% y T3= 25%. Los tratamientos fueron evaluados por un panel semi-entrenado, las cuales fueron sometidos a un análisis de varianza con el 95% de confiablidad empleando la prueba de contraste de Tuckey, determinándose que el T2 como el mejor en cuanto a sabor, consistencia, olor y apariencia.
La composición nutricional del mejor tratamiento en base a 100 gr, tuvó como resultados: carbohidratos 65.38, proteínas 1.97 y grasas 3.10 en cuanto a los micronutrientes en mg: calcio 32.00, fosforo 54.29, hierro 5.61 y potasio 92.29. así como: humedad de 15.65gr, acidez 0.078%, 94 °B y pH: 6,50. Los resultados microbiológicos indicaron que el producto cumple con los requisitos “del reglamento sobre vigilancia y control sanitario de alimentos y bebidas según Decreto Nº007-98-S. MINSA
OCORRÊNCIA E FATORES ASSOCIADOS AO TRAUMATISMO DENTOALVEOLAR NO BRASIL
Authors: Souto Figueiredo Mariana , De Cerqueira Almeida Maria Eduarda , Cangussu Ferrari Thiago , Chaves dos Santos Juan Pablo , Souto Figueiredo Nepomuceno Ana Flávia 
Published: July 2022

Introdução: As injúrias dentárias configuram-se como um importante problema de saúde pública, com destaque para o traumatismo dentoalveolar que pode impactar negativamente a qualidade de vida dos indivíduos acometidos. Objetivo: Analisar a ocorrência e fatores associados ao traumatismo dentoalveolar no Brasil durante o ano de 2021. Metodologia: Estudo epidemiológico observacional, com delineamento transversal, realizado por meio da análise de informações sobre os atendimentos odontológicos efetuados pelas Equipes de Saúde Bucal nas Unidades Básicas de Saúde do Brasil no ano de 2021. Resultados: Ao todo notificou-se 100.458 (3.721± 2390) atendimentos voltados para o manejo de traumatismo dentoalveolar no país, com proporção de 4,01% de atendimentos por esse agravo (p=0,07). A região nordeste (34,69%) se destacou com o maior número de notificações. Quanto ao perfil de pacientes, os sujeitos mais acometidos por esse agravo foram do sexo feminino (57,6%), e adultos (62,84%). O valor encontrado para o teste de coeficiente de correlação de Pearson foi maior do que 0 (p=0,07) Conclusão: O traumatismo dentoalveolar se configura como um agravo em saúde bucal importante para o Brasil. Dentre os fatores associados, durante o ano de 2021, destacou-se a maior propensão de indivíduos da região nordeste, adultos e do sexo feminino.
Rancangan Aplikasi Pembelajaran Bahasa Inggris Berbasis Multimedia Untuk Siswa Kelas 4 Sekolah Dasar
Authors: Dinata Hendra , Evelyn Evelyn 
Published: July 2022

Abstrak: Bahasa Inggris merupakan mata pelajaran wajib dalam pendidikan Sekolah Dasar (SD) sampai dengan Sekolah Menengah Akhir (SMA). Dalam kurikulum 2013 saat ini, terdapat beberapa kendala dalam proses belajar mengajar pada materi Simple Present Tense dan Present Continuous Tense. Kendalanya seperti fokus siswa yang singkat dan sulitnya siswa memahami persepsi materi, ditambah materi pada buku paket yang kurang terstruktur menyebabkan siswa kesulitan membedakan jenis-jenis tenses. Untuk itu, tujuan dari penelitian ini adalah untuk membantu peningkatan pemahaman siswa Sekolah Dasar terkait materi Bahasa Inggris melalui bantuan sebuah aplikasi pembelajaran berbasis multimedia. Aplikasi dikembangkan menurut langkah-langkah Software Development Life Cycle (SDLC) dan menyajikan materi Simple Present Tense dan Present Continuous Tense dalam bentuk teks, audio, video infografis, kalimat contoh yang disertai gambar, soal-soal latihan dan kuis. Siswa juga dapat menjalani sesi latihan dan kuis untuk menilai tingkat pemahaman mereka. Aplikasi yang dibuat akan diuji cobakan kepada siswa yang sebelumnya melakukan pre-test. Hasil evaluasi post-test telah menunjukkan kenaikan rata-rata hingga 28,69% pada nilai siswa setelah siswa menggunakan aplikasi pembelajaran ini. Hal ini menunjukkan bahwa aplikasi pembelajaran yang dikembangkan telah berhasil membantu siswa dalam memahami materi Bahasa Inggris khusus materi Simple Present Tense dan Present Continuous Tense.

Kata kunci: aplikasi pembelajaran, bahasa inggris, multimedia

Abstract: : English is a compulsory subject in Elementary School (SD) to Senior High School (SMA) education. In the current 2013 curriculum, there are several obstacles in the teaching and learning process in Simple Present Tense and Present Continous Tense. Constraints such as the short focus of students and the difficulty of students understanding the perception of the material, plus the material in the textbook which is less structured makes it difficult for students to distinguish the types of tenses For this reason, the purpose of this study is to help increase elementary school students' understanding of English material through the help of a multimedia-based learning application. The application was developed according to the Software Development Life Cycle (SDLC) steps and presents Simple Present Tense and Present Continuous Tense material in the form of text, audio, video infographics, sample sentences with pictures, practice questions and quizzes. Students can also undergo practice sessions and quizzes to assess their level of understanding. The application made will be tested on students who previously did the pre-test. The results of the post-test evaluation have shown an average increase of up to 28.69% in student scores after students use this learning application. This demonstrates that the developed learning tool was successful in assisting students in comprehending English content, particularly for the Simple Present Tense and Present Continuous Tense.
Normal Immunoglobulin (Human) 10% and Recombinant Human Hyaluronidase (HyQvia)
Authors: CADTH  
Published: July 2022

CADTH recommends that HyQvia should be reimbursed for the treatment of primary humoral immunodeficiency and secondary humoral immunodeficiency if certain conditions are met.
HyQvia should only be covered to treat adults with primary or secondary humoral immunodeficiency if it is covered in a similar way as other immunoglobulin replacement therapies (IgRTs) currently reimbursed for the treatment of these conditions.
HyQvia should only be reimbursed if prescribed by a specialist with appropriate knowledge and training in primary and secondary humoral immunodeficiency and if treatment with HyQvia does not cost more than the least costly IgRT currently reimbursed for this condition.
ABORDAGEM CIÊNCIA, TECNOLOGIA E SOCIEDADE (CTS) NA EDUCAÇÃO DE JOVENS E ADULTOS: PARA PROMOÇÃO DE UM ENSINO DE CIÊNCIAS COM SIGNIFICADO
Authors: Baptista Flávio Henrique 
Published: July 2022

Para atender as especificidades da modalidade de Educação de Jovens e Adultos (EJA), o ensino de ciências precisa compreender aspectos didáticos e pedagógicos, que atendam a função social e reparadora pretendida pela modalidade de ensino. Este ensaio tem como objetivo apresentar a Educação CTS, fundamentada na pedagogia de Paulo Freire, como alternativa para um ensino de ciências com significado na EJA. Através da pesquisa bibliográfica, tendo a Educação CTS como referencial, e a análise de documentos normativos, buscasse formas de promover um ensino de ciências que promova a formação para cidadania, pretendida na modalidade EJA. A inclusão de temas geradores, de relevância social ao ensino ciências, somados a interdisciplinaridade, favorecem a contextualização e consequentemente o aprendizado, contribuindo para a alfabetização científica. Este aprendizado é compreendido como fundamental para formação de cidadãos críticos, tomadores de decisão, capazes de contribuir no debate público a respeito de ciência e tecnologia, meio ambiente, educação e direcionamento de recursos. Os desafios apresentados na modalidade EJA, demandam educadores cientes de sua função social, comprometidos com o contexto escolar no qual estão inseridos.
CONTROLLER: RETRATO DO PROFISSIONAL DE CONTROLADORIA NO CENÁRIO BRASILEIRO
Authors: Tavares Celso Oliveira 
Published: July 2022

A controladoria é uma área de estudos que carece de definições e conceituações claras, isso inclui um conjunto básico de funções atribuídas ao Controller, profissional da área. Segundo os Princípios Globais de Contabilidade Gerencial (PGCG), a Controladoria é a base central para que as tomadas de decisões sejam adotadas levando em consideração a qualidade do trabalho executado e os resultados obtidos, uma vez que partem do princípio que produzir informações e análises mais relevantes que podem gerar e preservar valores para a organização. Diante disso, o objetivo desse estudo foi demonstrar o retrato do profissional controller, requerido pelas empresas atualmente, no mercado brasileiro. Para isso, foi utilizado a plataforma Linkedln Coporation para coletar e analisar dados correspondentes à oferta de vagas e as exigências requeridas pelas organizações para contratação do profissional no Brasil. Entre o período de 15 a 25 de abril de 2022, foram encontradas uma média de 352 vagas abertas, destas apenas 46 (13,1%) faziam jus concretamente ao cargo. Foi possível notar que a maior parte das vagas (80,4%, n=37) se concentra na região sudeste, sendo São Paulo o estado com mais ofertas. A formação acadêmica mais solicitada foi Ciências Contábeis (n=29, 49%). Entre as exigências para as vagas de emprego, foram incluídas: i) cursos adicionais (n=11, 24%); ii) experiência na área (n=10); iii) conhecimento específico de ERP, Excel (n=7/19, 37% cada), pacote office (n=5/19, 26%); iv) funções de gerenciamento da contabilidade, auditoria e controle financeiro, correspondendo a 76% (n=35) v) sendo as competências e habilidades mais exigidas a boa comunicação oral e escrita (13 observações); liderança, trabalho em equipe, trabalhar sob pressão, ser ágil, analítico e detalhista, (7 observações cada). Em referência aos resultados, pode-se sugerir que as funções do controller são diversificadas, sendo as características das organizações que irão determinar a aplicação de cada uma delas.
Revealed Comparative Advantages in the Services Trade of Pakistan: What do they tell us?
Authors: Rashid Rashid Naweed , Maqbool Shahid , Shafiq Azka , Afzal Maria 
Published: July 2022

The purpose of this study is to determine Pakistan's export competitiveness in the construction services sector on the global market. The competitiveness of Pakistan's service sector has been assessed using a variety of revealed comparative advantage indices from 2005-2020. The data have been collected from International Trade Center UNCOMTRADE statistics for exports of the services sector of Pakistan. The findings of the RCA, RSCA, Vollrath index, and InRCA indicate that Pakistan benefited from comparative advantage in the worldwide market for construction services from 2007 and 2016-2020, while Pakistan faced a comparative disadvantage in 2005-06 and 2008-15. Pakistan enjoyed a competitive advantage in the imports of the construction service sector by utilizing RMA index during 2006-2015 and in the year 2020, whereas Pakistan faced a competitive disadvantage in the imports in the other selected years. The RTA index portrays that Pakistan faced a net comparative advantage in the concerned sector in the years 2006-08, 2013-15, and 2020, while a net comparative disadvantage was observed in the remaining years. The trade balance index (TBI) highlights that Pakistan has become a net exporter in the services sector in the years 2007, 2014, 2015, and 2020, while Pakistan faced a net importer in the reaming years of the world economy. The present study recommended a method and strategy for addressing bottlenecks in the services sector's growth and for implementing a package of policy reforms to position the services sector as a critical sector for growth, employment, and poverty alleviation Information technology (IT) is ideally suited for cluster-based development in the services industry.