bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryoprotectant effects of natural honey on spermatozoa quality of pre-freezing and frozen-thawed boar semen
Authors: Balogun Kayode B , Nicholls Griffin , Sokunbi Olujide A , Stewart Kara R 
Published: November 2022

Abstract
Natural honey has been successfully used in the preservation of mammalian gametes because of its beneficial properties. The objectives of this study were to determine the inclusion level of honey in extender for improving boar semen quality before freezing and to investigate the effects of honey inclusion in extender and freezing media on post-thaw quality of frozen-thawed boar semen samples. Ejaculates from six terminally crossbred boars were collected using the gloved-hand technique for two experiments. Experiment 1 was a randomized block design, evaluating four inclusion levels of honey in boar semen extender [Control (0H)—Androhep Plus or Androhep Plus with 0.25%, 0.50%, and 0.75% honey (0.25H, 0.50H, and 0.75H respectively)]. Ejaculates were pooled, aliquoted according to treatments, and cooled for 24 h at 17 ºC. The results of this experiment were used to determine inclusion levels in exp. 2. Experiment 2 was a 2 x ×3 factorial design, evaluating the inclusion of honey in boar semen extender and freezing media. Semen samples from individual boars were cooled in extender with or without honey (C0: Androhep Plus; C1: Androhep Plus + 0.25% honey). After 24 h, semen samples were evaluated, diluted in lactose-egg yolk (LEY) media, and one of three freezing media types; F0: 93% LEY + 6% glycerol + 1% Equex-STM Paste (ESP); F1: 93% LEY + (3% glycerol and 3% honey) + 1% ESP; and F2: 93% LEY + 6% glycerol + (0.5% ESP and 0.5% honey). Samples were frozen in 0.5 mL straws using a controlled-rate freezer and stored in liquid nitrogen. In exp. 1, 0.25H and 0.50H improved motility (P = 0.033) and progressive motility (P = 0.001) of cooled boar semen. Nevertheless, 0.25H was selected for exp. 2. In exp. 2, post-thaw motility and progressive motility were highest (P &lt; 0.05) in C0F2 but not different from C1F2. Morphologically normal cells and acrosomes were higher with all inclusion levels of honey (P &lt; 0.05). In conclusion, 0.25% and 0.50% inclusion of honey in Androhep Plus improves motility and progressive motility of cooled boar semen samples after 24 h. Supplementing Androhep Plus with 0.25% honey maintains higher normal sperm cells and acrosomes of cryopreserved boar semen. Replacing 50% Equex-STM paste with honey in freezing media improves post-thaw sperm motility, progressive motility, percentage of normal sperm, and acrosome of cryopreserved boar semen.
Metabolic, antioxidant, and immune response of broodstock males ofPenaeus brasiliensisLatreille, 1817 fed diets supplemented by vitamin C
Authors: Montalvo Grecia , Morones Rodrigo , Barral-Pintos Xurxo , Arenas Martín , Barreto Alvaro , Escalante Karla , Cuzon Gerard , Gaxiola Gabriela 
Published: November 2022

AbstractControlling oxidative stress in shrimps under culture conditions is of vital importance to ensure that males have an optimal physiological status. The use of diets supplemented with vitamins are widely used for this purpose. We evaluated the effects of vitamin C on the metabolic, antioxidant, and immune responses of Penaeus brasiliensisLatreille, 1817 broodstock males under culture conditions. A formulated diet was used as a control (16 mg kg–1 of total ascorbic acid (vitamin C) content) and three diets were prepared with three vitamin C levels: 322 mg kg–1 (Diet A), 628 mg kg–1 (Diet B), and 934 mg kg–1 (Diet C). Triglycerides, cholesterol, glucose, and prophenoloxidase, total proteins, and quantity and type of hemocytes in the hemolymph were determined. We also quantified the antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx) and lipid peroxidation in the reproductive tract. Differentially expressed genes of the immune system, namely those of α-2 macroglobulin (α2M), peneidin (Pen), hemocyanin, prophenoloxidase, and the genes encoding the antioxidant enzymes SOD, CAT, and Gpx were quantified in the tract. Sperm quantity and quality were recorded. In males fed Diet C, the lowest cholesterol values and triglycerides obtained in the hemolymph were not significantly different from those fed the control diet (P &lt; 0.05); those fed Diet C showed the highest amount of hyaline hemocytes, the lowest CAT enzyme activity, and the highest Gpx activity. The immune system genes only showed differences between α2M and Pen; sperm quantity and quality were not affected by diet. The results indicated that Diet C (13.9 g kg–1 vitamin C) was effective for the maintenance of P. brasiliensis broodstock males because it controlled cholesterol and triglyceride levels; there was less CAT activity and less activation of the immune system mediated by hemocytes.
The effectiveness of consolidation chemotherapy in high-risk early-stage cervical cancer patients following concurrent chemoradiation after radical surgery
Authors: Wang Cong , Fu Chunli , Ma Changdong , Qian Qiuhong , He Fangfang , Zhang Guangyu 
Published: November 2022

Abstract

Objective
Studies determining which early-stage cervical cancer patients with high-risk factors benefit from consolidation chemotherapy after postoperative concurrent chemoradiotherapy (CCRT) are limited and inconsistent. The aim of this study was to evaluate the value of consolidation chemotherapy in early-stage cervical cancer.

Methods
From 2010 to 2019, a retrospective review was conducted among high-risk early-stage cervical cancer patients who were treated with postoperative CCRT or consolidation chemotherapy after postoperative CCRT. Disease-free survival (DFS) and overall survival (OS) were calculated using the Kaplan–Meier method and compared using the log-rank test.

Results
A total of 293 patients with early-stage cervical cancer were included in this study. A total of 188 patients were in the consolidation chemotherapy group, and 105 patients were in the postoperative CCRT alone group. The median follow-up was 48.3 months (range: 3–123 months). In the survival analyses, no significant differences in DFS (P = 0.21) or OS (P = 0.15) were observed between the groups. The grade 3–4 leukopenia and neutropenia rates in the consolidation group were higher than those in the concurrent chemoradiotherapy alone group (54.8% vs. 28.6%, P = 0.02; 49.4% vs. 10.5%, P = 0.001, respectively). For patients with ≥2 positive lymph nodes or ≥2 high-risk factors, consolidation chemotherapy significantly improved DFS (P = 0.013 and P = 0.002) and OS (P &lt; 0.001 and P &lt; 0.001) compared with CCRT alone.

Conclusion
For early-stage cervical cancer, consolidation chemotherapy after postoperative CCRT improved survival outcomes in patients with ≥2 positive lymph nodes or ≥2 high-risk factors.
Why Medicine Needs a Theology of Monstrosity
Authors: Stahl Devan 
Published: November 2022

AbstractFor centuries, philosophers and theologians debated the meaning of monstrous births. This article describes the debates that took place in the early modern period concerning the origins of monstrous births and examines how they might be relevant to our understanding of disability today. I begin with the central questions that accompanied the birth of conjoined twins in the early 17th century as well as the theological origins of those questions. I then show the shifts that occurred in philosophical debate in the 18th century, which reveal the changing understanding of God’s interaction with creation, as well as the burgeoning medical responses to monstrous births. By reexamining these earlier debates, I claim some of the earlier questions posed by philosophers and theologians have been neglected but remain relevant in bioethics debates concerning how best to consider and treat newborns with certain disabilities.
Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model
Authors: Li Nini , Zhang Dongdong , Guo Hena , Yang Qian , Li Peng , He Yifan 
Published: November 2022

Abstract
Circ_0004381 promotes neuronal damage in Parkinson disease, but its role in Alzheimer disease (AD) is unreported. The goal of this study was to investigate the role and potential mechanisms of circ_0004381 effects in AD models. Primary hippocampal neurons were treated with amyloid-β (Aβ1–42) to construct AD cell models. We found that circ_0004381 was upregulated in Aβ1–42-treated hippocampal neurons. Knockdown of circ_0004381 attenuated Aβ1–42-induced apoptosis, oxidative stress, and mitochondrial dysfunction in hippocampal neurons. Next, we induced microglia activation with lipopolysaccharide (LPS). The results of flow cytometry experiments showed that knockdown of circ_0004381 promoted microglial M2-type polarization and knockdown of circ_0004381 inhibited the production of inflammatory factors by microglia. Furthermore, knockdown of circ_0004381 improved cognitive function of male APPswe/PS1dE9 transgenic mice. Mechanistically, circ_0004381 regulated presenilin-1 (PSEN1) expression by absorbing miR-647. MiR-647 inhibition attenuated the effects of circ_0004381 knockdown. In conclusion, knockdown of circ_0004381 attenuated hippocampal neuronal damage and promoted microglia M2-type polarization through the miR-647/PSEN1 axis, ultimately improving cognitive function in AD model mice.
Revealing galaxy candidates out to z ∼ 16 with JWST observations of the lensing cluster SMACS0723
Authors: Atek Hakim , Shuntov Marko , Furtak Lukas J , Richard Johan , Kneib Jean-Paul , Mahler Guillaume , Zitrin Adi , McCracken H J , Charlot Stéphane , Chevallard Jacopo , Chemerynska Iryna 
Published: November 2022

ABSTRACT
One of the main goals of the JWST is to study the first galaxies in the Universe. We present a systematic photometric analysis of very distant galaxies in the first JWST deep field towards the massive lensing cluster SMACS0723. As a result, we report the discovery of two galaxy candidates at z ∼ 16, only 250 million years after the big bang. We also identify two candidates at z ∼ 12 and six candidates at z ∼ 9−11. Our search extended out to z ≲ 21 by combining colour information across seven near-infrared camera and near-infrared imager and slitless spectrograph filters. By modelling the Spectral Energy Distributions (SEDs) with EAZY and BEAGLE, we test the robustness of the photometric redshift estimates. While their intrinsic (unlensed) luminosity is typical of the characteristic luminosity L* at z &gt; 10, our high-redshift galaxies typically show small sizes and their morphologies are consistent with disks in some cases. The highest-redshift candidates have extremely blue ultraviolet-continuum slopes −3 &lt; β &lt; −2.4, young ages ∼10−100 Myr, and stellar masses around log (M⋆/M⊙) = 8.8 inferred from their spectral energy distribution modelling, which indicate a rapid build-up of their stellar mass. Our search clearly demonstrates the capabilities of JWST to uncover robust photometric candidates up to very high redshifts and peer into the formation epoch of the first galaxies.
Variability in a low-mass active galactic nucleus: oscillation or eruption?
Authors: Webbe Robbie , Young A J 
Published: November 2022

ABSTRACT
Following the discovery of a new class of X-ray variability seen in four galaxies, dubbed quasi-periodic eruptions (QPEs), we reconsider the variability seen in the low-mass active galactic nucleus (AGN) 2XMM J123103.2+110648 to ascertain whether it should be considered a QPE host galaxy. We apply the autocorrelation function to two archival XMM–Newton observations to determine characteristic time-scales for variability of ∼13.52 and ∼14.35 ks. The modelling of light curves, both folded at these time-scales and unfolded, indicates that a Gaussian model is preferable over a sinusoidal model, with average durations for the bright phases of 6.17 and 7.69 ks. In a broad 0.2–1.0 keV band the average amplitude of the bright phases was found to be 2.86 and 8.56 times the quiescent count rate. The pattern of variability seen in 2XMM J123103.2+110648 cannot be definitively declared as a series of QPEs. Instead, this suggests there may be a continuum of quasi-periodic variability ranging from eruptions to oscillations being caused by a single mechanism. This offers the possibility of finding further sources that continue to bridge the gap between QPEs and quasi-periodic oscillations (QPOs). A targeted analysis of 47 observations of 11 other low-mass AGN (log (MBH) ≲ 6) found no evidence of QPE- or QPO-like behaviour in a sample of other similar mass objects.
Deep drilling in the time domain with DECam: survey characterization
Authors: Graham Melissa L , Knop Robert A , Kennedy Thomas D , Nugent Peter E , Bellm Eric , Catelan Márcio , Patel Avi , Smotherman Hayden , Soraisam Monika , Stetzler Steven , Aldoroty Lauren N , Awbrey Autumn , Baeza-Villagra Karina , Bernardinelli Pedro H , Bianco Federica , Brout Dillon , Clarke Riley , Clarkson William I , Collett Thomas , Davenport James R A , Fu Shenming , Gizis John E , Heinze Ari , Hu Lei , Jha Saurabh W , Jurić Mario , Kalmbach J Bryce , Kim Alex , Lee Chien-Hsiu , Lidman Chris , Magee Mark , Martínez-Vázquez Clara E , Matheson Thomas , Narayan Gautham , Palmese Antonella , Phillips Christopher A , Rabus Markus , Rest Armin , Rodríguez-Segovia Nicolás , Street Rachel , Vivas A Katherina , Wang Lifan , Wolf Nicholas , Yang Jiawen 
Published: November 2022

ABSTRACT
This paper presents a new optical imaging survey of four deep drilling fields (DDFs), two Galactic and two extragalactic, with the Dark Energy Camera (DECam) on the 4-m Blanco telescope at the Cerro Tololo Inter-American Observatory (CTIO). During the first year of observations in 2021, &gt;4000 images covering 21 deg2 (seven DECam pointings), with ∼40 epochs (nights) per field and 5 to 6 images per night per filter in g, r, i, and/or z have become publicly available (the proprietary period for this program is waived). We describe the real-time difference-image pipeline and how alerts are distributed to brokers via the same distribution system as the Zwicky Transient Facility (ZTF). In this paper, we focus on the two extragalactic deep fields (COSMOS and ELAIS-S1) characterizing the detected sources, and demonstrating that the survey design is effective for probing the discovery space of faint and fast variable and transient sources. We describe and make publicly available 4413 calibrated light curves based on difference-image detection photometry of transients and variables in the extragalactic fields. We also present preliminary scientific analysis regarding the Solar system small bodies, stellar flares and variables, Galactic anomaly detection, fast-rising transients and variables, supernovae, and active Galactic nuclei.
MeerKAT’s view of the bullet cluster 1E 0657-55.8
Authors: Sikhosana S P , Knowles K , Hilton M , Moodley K , Murgia M 
Published: November 2022

ABSTRACT
The Bullet cluster (1E 0657-55.8) is a massive merging system at redshift z = 0.296, known to host a powerful radio halo and a relic. Here we present high fidelity MeerKAT L-band (0.9–1.7 GHz) observations of the Bullet cluster, where we trace a larger extent of both the halo and relic in comparison to previous studies. The size of the recovered halo is 1.6 Mpc × 1.3 Mpc and the largest linear size of the relic is ∼988 kpc. We detect a new decrement feature on the southern outskirts of the halo emission, where a region appears to have a lower surface brightness in comparison to its surroundings. The larger extension on the outskirts of the halo is faint, which suggests lower relativistic electron density or a weaker magnetic field. An in-band spectral index map of the halo reveals radial steepening towards the edges, likely due to synchrotron electron ageing. The integrated spectral index of the radio halo is 1.1 ± 0.2. We perform a radio−X-ray surface brightness point-to-point analysis, which reveals a linear correlation for the radio halo. This indicates that the halo emission is produced by primary re-acceleration mechanisms. Finally, we derive a radio Mach number of $\mathcal {M}_R$ = 4.6 ± 0.9 for the relic shock region, which is higher than the Mach number inferred by earlier analyses based on X-ray data. Discrepancies between radio and X-ray Mach numbers have been observed for multiple systems, studies suggest that this is due to various factors, including relic orientation.
The Pristine survey – XIX. Cu and Zn abundances in metal-poor giants
Authors: Caffau E , Lombardo L , Mashonkina L , Sitnova T , Bonifacio P , Matas Pinto A M , Kordopatis G , Sestito F , Aguado D , Salvadori S , Spite M , François P , Sbordone L , Mucciarelli A , Martin N , Fernández-Alvar E , González Hernández J I 
Published: November 2022

ABSTRACTMetal-poor stars formed from a gas enriched by the ejecta of the explosion of one/few generations of first massive stars. With the Pristine photometry combined with the Gaia data, we selected a sample of bright giants metal-poor candidates to be observed at high resolution. Of the 43 stars observed, 36 were confirmed to be metal-poor, supporting the high success-rate of Pristine in selecting metal-poor stars. We centred the investigation on Cu and Zn, which are elements usually neglected, also because they are the ‘killing elements’ for identifying the Pair Instability Supernovae (PISN) descendants, the explosion of very massive first stars. We derived detailed chemical abundances of 22 species of 18 elements for 36 giant stars. The study of the kinematics of the stars in the sample revealed the presence of metal-poor stars on disc-like orbits (17 per cent of the sample) and even on thin disc orbits (8 per cent of the sample). Four stars are members of the Gaia–Sausage–Enceladus, one star is also likely a member of it. Three stars in the sample (TYC 1118−595−1, TYC 2207−992−1, and TYC 1194−507−1) show a chemical pattern compatible with the one theoretically derived for the PISN descendants, i.e. stars formed out from a gaseous environment enriched by PISN (&gt;50 per cent level) and subsequent generations of normal stars evolving as core-collapse SNe.
The effect of scattering calculations on non-LTE modelling of the C3O and C5O abundances in TMC-1
Authors: Bop C T , Khadri F , Hammami K 
Published: November 2022

ABSTRACT
Tricarbon and pentacarbon monoxides have been detected towards the Taurus Molecular Cloud (TMC-1) with relatively important abundances. Understanding the chemical formation of these molecules requires interpreting their observational spectra by mean of non-local thermodynamical equilibrium modelling. For this purpose, we report rate coefficients of  C3O and  C5O induced by collision with He for temperatures up to 100 K. These data are obtained by calculating inelastic cross sections for the 31 low-lying rotational levels of  C3O and  C5O using the close-coupling approach. The comparison of the new rate coefficients with those of HC3N and HC5N, previously used to interpret the observational spectra of  C3O and  C5O, reveals differences of up to an order of magnitude. The effect of the new collisional rate coefficients in radiative transfer calculations is checked by computing the excitation temperatures for some transitions and simulating the  C3O and  C5O column densities observed towards TMC-1. Our findings suggest that the use of HCnN as template for CnO may lead to local thermodynamic equilibrium conditions for gas densities as low as ∼103  cm−3. Regarding the interpretation of the observational spectra, using radiative transfer modelling based on the actual CnO collisional rate coefficients instead of rotational diagram analysis leads to underestimate the column densities reported in the literature by up to 25 per cent and accordingly the  C3O/ C5O abundance ratio by up to 50 per cent. We expect that the new rate coefficients and the radiative transfer calculations presented in this work will encourage further modellings of the CnO abundance and accordingly constrain the chemistry.
Neutron star inner crust: reduction of shear modulus by nuclei finite size effect
Authors: Zemlyakov Nikita A , Chugunov Andrey I 
Published: November 2022

ABSTRACT
The elasticity of neutron star crust is important for adequate interpretation of observations. To describe elastic properties one should rely on theoretical models. The most widely used is Coulomb crystal model (system of point-like charges on neutralizing uniform background), in some works it is corrected for electron screening. These models neglect finite size of nuclei. This approximation is well justified except for the innermost crustal layers, where nuclei size becomes comparable with the inter-nuclear spacing. Still, even in those dense layers it seems reasonable to apply the Coulomb crystal result, if one assumes that nuclei are spherically symmetric: Coulomb interaction between them should be the same as interaction between point-like charges. This argument is indeed correct; however, as we point here, shear of crustal lattice generates (microscopic) quadrupole electrostatic potential in a vicinity of lattice cites, which induces deformation on the nuclei. We analyse this problem analytically within compressible liquid drop model. In particular, for ground state crust composition the effective shear modulus is reduced for a factor of $1-u^{5/3}/(2+3\, u-4\, u^{1/3})$, where u is the ratio of the nuclei volume to the volume of the cell. This result is universal, i.e. it does not depend on the applied nucleon interaction model within applied approach. For the innermost layers of inner crust u ∼ 0.2 leading to reduction of the shear modulus by $\sim 25{{\ \rm per\ cent}}$, which can be important for correct interpretation of quasi-periodic oscillations in the tails of magnetar flares.
Accelerating cosmological inference with Gaussian processes and neural networks – an application to LSST Y1 weak lensing and galaxy clustering
Authors: Boruah Supranta S , Eifler Tim , Miranda Vivian , Krishanth P M Sai 
Published: November 2022

ABSTRACT
Studying the impact of systematic effects, optimizing survey strategies, assessing tensions between different probes and exploring synergies of different data sets require a large number of simulated likelihood analyses, each of which cost thousands of CPU hours. In this paper, we present a method to accelerate cosmological inference using emulators based on Gaussian process regression and neural networks. We iteratively acquire training samples in regions of high posterior probability which enables accurate emulation of data vectors even in high dimensional parameter spaces. We showcase the performance of our emulator with a simulated 3×2 point analysis of LSST-Y1 with realistic theoretical and systematics modelling. We show that our emulator leads to high-fidelity posterior contours, with an order of magnitude speed-up. Most importantly, the trained emulator can be re-used for extremely fast impact and optimization studies. We demonstrate this feature by studying baryonic physics effects in LSST-Y1 3×2 point analyses where each one of our MCMC runs takes approximately 5 min. This technique enables future cosmological analyses to map out the science return as a function of analysis choices and survey strategy.