bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants
Authors: Chen Li-Na , Wang Si-Jie , Wang Song-Mei , Fu Xiao-Li , Zheng Wen-Jing , Hao Zhi-Yong , Zhou Hai-Song , Zhang Xin-Jiang , Zhao Yu-Liang , Qiu Chao , von Seidlein Lorenz , Qiu Tian-Yi , Wang Xuan-Yi 
Published: November 2022

Abstract
Background:
Norovirus, is the leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the ORF2 for norovirus. However, strains causing asymptomatic infection were not considered.
Methods:
we conduct the first norovirus molecular epidemiology analysis covering both symptomatic and asymptomatic infections derived from a birth cohort study in the northern China.
Results:
During the study, 14 symptomatic and 20 asymptomatic norovirus infections were detected in 32 infants. Out of the 14 strains that caused symptomatic infections, 12 strains were identified as GII.3 [P12], and others were GII.4 [P31]; conversely, 17 asymptomatic infections were caused by GII.4 [P31], two by GII.2 [P16], and one by GII.4 [P16]. Regardless whether symptomatic and asymptomatic the mutations were detected frequently in the ORF2 region, and almost all recombinations were identified in the RdRp region. The majority of the mutations were located around the predefined epitope regions of P2 subdomain indicating a potential for immune evasion.
Conclusion:
The role of asymptomatic infection in the evolution of noroviruses needs to be evaluated continuously.
QSAR study, molecular docking and molecular dynamic simulation of Aurora kinase inhibitors derived from imidazo[4,5-b]pyridine derivatives
Authors: Tong Jian-Bo , Xiao Xue-chun , Bian Shuai , Luo Ding , Zhang Xing 
Published: November 2022

Abstract

Cancer is a serious threat to human life and social development and the use of scientific methods for cancer prevention and control is necessary. In this study, HQSAR, CoMFA, CoMSIA and TopomerCoMFA methods were used to establish models of 65 imidazo[4,5-b]pyridine derivatives to explore the quantitative structure activity relationship between their anticancer activities and molecular conformations. The results showed that the cross-validation coefficients q2 of HQSAR, CoMFA, CoMSIA and TopomerCoMFA were 0.892, 0.866, 0.877 and 0.905, respectively. The non-cross-validation coefficients r2 were 0.948, 0.983, 0.995 and 0.971, respectively. The externally validated complex correlation coefficients r2pred of external validation were 0.814, 0.829, 0.758 and 0.855, respectively. The PLS analysis verified the QSAR models we established with high prediction ability and stability. Based on these statisticians, virtual screening based on R group was done in ZINC database by using the Topomer search technology. Finally, 10 new compounds with higher activity were designed with the screened new fragments. In order to explore the binding modes and targets between ligands and protein receptors, these newly designed compounds were conjugated with macromolecular protein (PDB ID: 1MQ4) by molecular docking technology. Furthermore, to study the nature of newly designed compound in dynamic states and the stability of protein-ligand complex, molecular dynamics simulation for 50ns was carried out for N3, N4, N5 and N7 docked with 1MQ4 protease structure. Free energy landscape was computed to search the most stable conformation. These results proved the efficient and stability of the newly designed compounds. Finally, ADMET was used to predict the pharmacology and toxicity of the designed 10 drug molecules to test their pharmacological effects and safety.
Direct Observation of Hot-Electron-Enhanced Peltier Effects in Silicon Nanodevices
Authors: An Zhenghua , Xue Huanyi , Qian Ruijie , Gong Xue , Qin Ludi , Lu Weikang , Zhong Zhenyang , Chen Lidong , Lu Wei 
Published: November 2022

Abstract
The study of thermoelectric behaviors in miniatured transistors is of fundamental importance for developing bottom-level thermal management. Recent experimental progress in nanothermetry has enabled studies of the microscopic temperature profiles of nanostructured metals, semiconductors, two-dimensional material, and molecular junctions. However, observations of Peltier effect in prevailing silicon (Si)—a critical step for on-chip refrigeration using Si itself—have not been addressed so far. Here, we carry out nanothermometric imaging of both electron temperature (Te) and lattice temperature (TL) of a Si nanoconstriction device and find obvious Peltier effect in the vicinity of the electron hotspots: When the electrical current passes through the nanoconstriction channel generating electron hotspots (with Te~1500 K being much higher than TL~320 K), prominent Peltier effect is directly visualized attributable to the extremely large electron temperature gradient (~1 K/nm). The quantitative measurement shows a distinctive third-power dependence of the observed Peliter on the electrical current, which is consistent with the theoretically predicted nonequilibrium Peltier effects. Our work suggests that the nonequilibrium hot carriers may be potentially utilized for enhancing the thermoelectric performance and therefore sheds new light on the nanoscale thermal management of post-Moore nanoelectronics.
Reaction Mechanism of Methyl Trifluoroacetate (CH 3 TFA) with Lithium Polysulfides (Li 2 S 6 ) in Gas and Solvent Phase
Authors: Cheviri Meera , Lakshmipathi Senthilkumar 
Published: November 2022

Abstract
In this DFT study, we have evaluated the reaction mechanism of lithium polysulfide (Li2S6) with the electrolyte additive methyl trifluoroacetate (CH3TFA) in the gas and solvent (dimethoxyethane (DME)) phase at room temperature (298 K) by locating transition states (TS) for the methyl group transfer from CH3TFA to Li2S6, which is reported to produces organosulfur ((CH3)2S6). All the reported methyl transfer reactions that lead to the formation of organosulfur are having high barrier energy. The barrier energy difference between gas and solvent phase is maximum of 7 kcal/mol and both the reactions are in extreamely slow regime. therefore, the methyl transfer reaction for the formation of organosulfur implausible at room temperature.
Cold-Induced RNA-Binding Protein and RNA-Binding Motif Protein 3: Two RNA Molecular Chaperones Closely Related to Reproductive Development and Reproductive System Diseases
Authors: Jin Yuji , Jiang Yong , Liu Jiahao , Wei Qinqin , Jin Yingji 
Published: November 2022

Abstracts:Cold-induced RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) have recently been reported to be involved in cold stress in mammals. These proteins are expressed at low levels in various normal cells, tissues, and organs but can be upregulated upon stimulation by multiple stressors. Studies have shown that CIRP and RBM3 are multifunctional RNA molecular chaperones with different biological functions in various physiological and pathophysiological processes, such as reproductive development, the inflammatory response, the immune response, nerve injury regulation, and tumorigenesis. This paper reviews recent studies on the structure, localization and correlation of CIRP and RBM3 with reproductive development and reproductive system diseases.
Lipoprotein (a) Levels and Abdominal Aortic Aneurysm. A Systematic Review
and Meta-analysis
Authors: Oikonomou Evangelos , Lampsas Stamatios , Pantelidis Panteleimon , Theofilis Panagiotis , Grammatopoulos Konstantinos , Marathonitis Anastasios , Vavuranakis Michael A , Siasos Gerasimos , Tousoulis Dimitris , Vavuranakis Manolis 
Published: November 2022

Background:
Several studies have linked high Lipoprotein (a) [Lp(a)] concentrations to cardiovascular events, including the formation of Abdominal Aortic Aneurysms (AAA). We review and meta-analyze existing evidence on the association of Lp(a) levels with AAA.

Methods:
Studies evaluating the link of Lp(a) with AAA, up to December 27th 2021, were identified by a systematic search of PubMed, SCOPUS, and Web of Science databases. The results were qualitatively and quantitatively synthesized according to PRISMA guidelines. Results are presented as standardized mean differences (SMD) with 95% confidence intervals (CI).

Results:
A total of 5,078 subjects (1,637 patients with AAA vs. 3,441 controls) from 11 studies were included
in the meta-analysis, with a mean age of 69.9 years and a male sex prevalence of 85.8%. Based on the qualitative synthesis, high Lp(a) concentrations are linked to abdominal aortic wall degradation and extracellular matrix disarrangement. Moreover, despite the considerable variability among races, high Lp(a) levels are related to
increased AAA risk, independently of race differences. Accordingly, patients with AAA displayed significantly
higher Lp(a) levels compared to controls (SMD: 0.86, 95% CI: 0.55-1.17, p<0.001). The outcome was not affected in a sensitivity analysis excluding three outlying studies (SMD: 0.40, 95% CI: 0.22-0.58, p<0.001).

Conclusion:
This meta-analysis indicates the association between high Lp(a) levels and the presence of AAA,
although existing literature presents high heterogeneity. Further studies are needed to standardize Lp(a) measurements and to conclude whether Lp(a) can be used as a sensitive biomarker of early presymptomatic AAA
diagnosis.
Evaluation of Vulnerability Factors for Developing Stress and Depression due to COVID-19 Spread and its Associated Lockdown
Authors: Alhusban Ahmed , Alzoubi Karem H. , Al-Azzam Sayer , Nuseir Khawla Q 
Published: November 2022

Background:
COVID-19 is a pandemic that has been widespread throughout the world. The disease and the measures employed to contain its spread have a detrimental effect on the mental health of individuals. Countries across the world have applied variable combinations of quarantine and social distancing measures to contain the spread of COVID-19. This project aims at identifying the susceptible groups for the development of depression and stress due to COVID-19-associated containment measures. This evaluation will help in prioritizing efforts to ameliorate the detrimental effects of COVID-19 on psychological health.

Methods:
A cross-sectional study was conducted through an online survey that included questions on the demographics and COVID-19 experience. The prevalence of depressive symptoms was evaluated using the PHQ-9 survey, whereas stress levels were detected using the perceived stress scale (PSS). Data regarding demographics as well as exposure to COVID-19, working at home and the financial impact of the pandemic were collected.

Results:
Data were collected from 1541 participants from the MENA region. Depressive symptoms were detected in 54.2% of the participants, and the average stress score was 18.4±0.8. Adjusting for demographics and other variables, younger participants were more likely to report depressive symptoms and higher stress scores. Additionally, younger age, female gender, the coexistence of depressive symptoms, negative effects on monthly income, and ability to do work were found to be independent predictors of higher stress scores.

Conclusion:
Young individuals are more likely to develop depression symptoms and stress. Thus, there is a need for prompt measures to alleviate COVID-19-associated effects on this group.
Validity and Reliability of the Digital Functioning Assessment Short Test (D-FAST) in the Brazilian Sample
Authors: Serafim Silvia Dubou , Goularte Jeferson Ferraz , Caldieraro Marco Antonio , Lima Flavia Moreira , Dalpiaz Giovana , Rabelo-da-Ponte Francisco Diego , Torrent Carla , Solé Brisa , Vieta Eduard , Rosa Adriane Ribeiro 
Published: November 2022

Background:
The COVID-19 pandemic has caused major disruptions in all aspects of daily functioning, from school and work to interactions with friends and family. The Functioning Assessment Short Test (FAST) is an interviewer-administered scale validated in the psychiatric sample with no previous study assessing its validity and reliability in a digital format. Thus, we aimed to analyse the psychometric properties of the digital version of the FAST and understand the implications of COVID-19 and restrictive measures on functioning.

Methods:
Data were collected using an online survey. The psychometric properties of the digital FAST were assessed by confirmatory factor analysis, Cronbach’s alpha, and discriminant functional by cluster analysis in a community sample.

Results:
Out of the total sample, 2,543 (84.1%) were female, and the mean (SD) age was 34.28 (12.46) years. The digital FAST retained the six factors structure observed in the original version, with Cronbach’s alpha above 0.9. In addition, we showed evidence of discriminant validity by differentiating three clusters of psychosocial functioning. Clinical and demographic differences between groups explained, in part, the heterogeneity of functioning, thus providing support for the construct validity of the instrument.

Conclusion:
The digital FAST is a simple and easy-to-understand instrument that provides a multidimensional assessment of functioning without the need for an interviewer. Furthermore, our findings may help to better understand the psychosocial implications of the pandemic and the importance of planning specific interventions to rehabilitee the affected group.
Phân tích các yếu tố ảnh hưởng đến ổn định bờ sông: Trường hợp nghiên cứu tại đoạn sông Chà Và, tỉnh Vĩnh Long
Authors: Trần Văn Tỷ , Phạm Hồng Tiến , Lâm Văn Thịnh , Huỳnh Thị Cẩm Hồng , Cù Ngọc Thắng , Đinh Văn Duy , Nguyễn Thái An , Lưu Quốc Anh , Nguyễn Thành Liêm 
Published: November 2022

Mục tiêu của nghiên cứu này là phân tích ảnh hưởng của các yếu tố địa chất thủy văn và gia tải đến ổn định bờ sông Chà Và, tỉnh Vĩnh Long. Ảnh vệ tinh tải về từ phần mềm Google Earth được sử dụng để đánh giá mức độ sạt lở bờ sông và mức độ đô thị hóa ven sông. Các số liệu sơ cấp và thứ cấp như địa hình, địa chất, thủy văn và sóng tàu được thu thập và phân tích. Hệ số an toàn được sử dụng để phân tích mức độ ổn định bờ sông. Các thông số đầu vào của mô hình được lấy từ các số liệu phân tích các yếu tố địa chất, mực nước, tải trọng sóng và tải trọng do quá trình đô thị hóa. Vận tốc dòng chảy thực đo được so sánh với vận tốc không xói của bùn cát cấu tạo bờ sông để đánh giá khả năng gây xói của vận tốc. Kết quả phân tích cho thấy xói lở và bồi tụ đang diễn ra dọc theo đoạn sông nghiên cứu. Vận tốc dòng chảy là một trong những nguyên nhân gây...
Pendekatan Model Analisis Persentase Berat Butiran Pupuk Kompos Daun Bambu
Authors: Sugiarto Raden , Purwanti Noordiana Herry 
Published: November 2022

Pupuk kompos berbahan dasar daun bambu berbentuk granul luaran IbM 2017 belum seragam ukuran butiran maupun kekerasannya, sehingga kurang efektif dan efisien apabila digunakan pada tanaman khususnya dalam budidaya hidroponik di perkotaan. Pendekatan model analisis ukuran butiran sebagai upaya perbaikan mutu serapan dan efisiensi penggunaan pupuk kompos berbahan dasar daun bambu, merupakan penerapan inovasi granulasi pupuk hasil IbM 2017 dan PKM 2018. Tujuan penelitian ini adalah untuk menghasilkan model pembuatan pupuk kompos daun bambu bentuk granul yang seragam ukuran dan lepas lambat hara, mendapatkan komposisi daun bambu dan pupuk kandang yang tepat agar diperoleh pupuk granul dengan kandungan hara dan mutu yang optimum, membuat ukuran diameter sesuai dengan kebutuhan pengguna. Penelitian dilaksanakan di laboratorium Teknologi Tepat Guna Institut Pertanian (INTAN) Yogyakarta melalui mengembangkan model pendekatan analisis dimensi yang akan mampu menduga beragam ukuranpupuk butiran. Pupuk butiran selanjutnya diuji kelambatan dalam melepas unsur haranya. Hasil penelitian menunjukkan bahwa berat butiran ditentukan oleh masa bahan organik, kepadatan butiran, kecepatan putar pembutiran, waktu putar dan berat pupuk kandang sebagai campuran
Autochthonous visceral leishmaniasis in the Russian Federation and the role of polymerase chain reaction as an alternative diagnostic method
Authors: Lebedeva T. M. , Chuelov S. B. , Sayfullin М. А. , Rossina A. L. , Zvereva N. N. , Pylaeva E. Y. , Volkova G. I. , Ivanova Yu. N. , Kryukova L. V. , Litsev A. A. , Karan L. S. 
Published: November 2022

The aim of the work is to summarize the available literature data on cases of visceral leishmaniasis in children registered in the Russian Federation, as well as to describe our own clinical observation of autochthonous visceral leishmaniasis in a 9-year-old child, in the diagnosis of which the polymerase chain reaction (PCR) method was used.Materials and methods: a review of domestic and foreign literature over the past 20 years, including Internet resources, was carried out. We observed a 9-year-old child hospitalized in the Russian Children's Clinical Hospital. Leishmania DNA was determined in blood serum by PCR using the Amplisens – Leishmania-Fl reagent kit.Results. It was established that the infection of the patient observed by us occurred on the territory of the Russian Federation in the Crimea. The diagnosis of leishmaniasis was confirmed by morphological examination of the bone marrow and the detection of pathogen DNA in the blood serum by PCR.Conclusion. On the territory of the Russian Federation there are foci of autochthonous visceral leishmaniasis in the Crimea and the North Caucasus. Polymerase chain reaction is an alternative to bone marrow aspirate microscopy for the diagnosis of visceral leishmaniasis.
Clinical and etiological characteristics of mixed infections in children in the Izhevsk hospital
Authors: Britkova T. A. , Panteleev K. E. , Pazinenko O. A. 
Published: November 2022

Aim: to study the structure, features of the findings and treatment of mixed infections in children at the present stage.Materials and methods. 85 case histories of children aged 5 months to 17 years and 10 months were examined, the final diagnosis of which included 2 or more infections on the basis of the children's infectious diseases department City Clinical Hospital № 7 of Izhevsk. Children with acute infectious pathology (acute intestinal infections, acute respiratory infections, herpes infections) are hospitalized in this hospital. Diagnostic methods: polymerase chain reaction, ELISA, bacteriological.Results. Mixed infections are equally common in both boys and girls, while there is a predominance of mixed infections in young children (up to 1 year and from 1 year to 3 years) 62.4%. The structure of infectious morbidity is consistently dominated by acute enteric infection – 83.5% cases and acute respiratory infections – 53.0% cases. The progression of SARS-CoV-2-associated and herpes-associated mixed infections is characterized by a pronounced polymorphism of clinical manifestations. The etiological factor for each nosology was deciphered only in 17.7%; in 43.5% of cases, only one etiological factor was verified in the laboratory; in 38.8% of cases, no etiological factor was confirmed in the laboratory.
TELAAH FILOSOFIS ATAS ARSITEKTUR DIGITAL Kasus Studi Arsitektur Digital Neo-Nusantara di Ibu Kota Negara (IKN)
Authors: Soesilo Rudyanto 
Published: November 2022

All aspects of life cannot escape the development of the times with the last phenomenon being the influence of the development of the digital world which is called the process of "digitalization". Architecture as one aspect of life certainly does not escape undergoing this digitilization process. Aim this paper discusses the process of digitalizing architecture using a philosophical point of view. The research was conducted using Desk research, from data and existing literature. The data is then filtered according to its interrelationships, validity and adjusted to its needs. Then a predictive analysis was carried out to get a (hypothetical) conception of digital architecture digital architecture in IKN Nusantara. The results of this discussion are understanding of the application of the digital ontological paradigm into the architectural process carried out at IKN Nusantara as a study case and in the context of the creative economy, which is the future of the Indonesian Economy, is very appropriate to develop a Neo-vernacular Digital Architecture in Indonesia which is hereinafter referred to as Neo-Nusantara Architecture.
Dehiscence of Uterine Hysteroraphy After Caesarian Section Associated with Secondary Anemia, Subaponevrotic Hematoma or Dehiscence of Skin Wound
Authors: Ana-Maria Brezeanu , Dragos-Marian Brezeanu , Vlad-Iustin Tica 
Published: November 2022

Abstract
Introduction: The incidence of cesarean section has increased significantly in recent years. The study is retrospective and observational, over a period of 5 years (From April 2017 to April 2022). The present paper aims to show the correlation between the dehiscence of the hysteroraphic tranche, with anemia, the postoperative hematoma or the dehiscence of the skin wound in the postoperative period.
Working method: This study was performed on a group of 5562 patients who gave birth by caesarean section, and found 4 patients who met the inclusion criteria. The inclusion criteria were secondary anemia, subaponevrotic haematoma or cutaneous wound dehiscence, associated with uterine dehiscence, followed by hysterectomy.
Results: Patients with uterine wound dehiscence had subaponevrotic hematoma in all cases (100%) and only one patient had an association between a supraaponevrotic hematoma and a subaponevrotic hematoma (11%).
From the perspective of cutaneous wound dehiscence, of the nine patients included in the study, only one patient (11%) presented wound dehiscence after hysterectomy. This patient did not need suturing of the wound, being treated conservatively.
Conclusions: Out of the studied group of 5562 patients, 16 patients developed subaponevrotic haematomas, 4 of them developing uterine histeroraphy dehiscence and requiring a hysterectomy, with an incidence of 25%.
Aspects of Epidemiology and Treatment of Supracondylar Fractures of the Humerus in Children in South-Eastern Romania
Authors: Alexandru Valcu , Iulian Manac , Bogdan Obada 
Published: November 2022

Abstract
Supracondylar fractures are frequently encountered in childre and have a high prevalence of associated complications. Supracondylar fractures, due to their frequency, aspect and the serious health problems that can result, require a rapid and precise intervention, based on a well-defined evaluation methodology
In this paper, we assess the epidemiology and the management of supracondylar fractures treated within the Surgery and Pediatric Orthopedics Clinic of the Emergency County Hospital of Constanta.
We conducted a retrospective study on 222 pediatric patients with supracondylar fractures of the humerus during between 2019 and 2021 treated in County Clinical Emergency Hospital of Constanta. The data was collected from the medical records of the patients recorded on the Clinic of Pediatric Surgery and Pediatric Orthopedics.
We obtained a higher percentage of males with fractures (60%). Falling from the same level was the main cause of fracture, followed at close distance by fall from different level, other causes, among which car accidents being observed less in our study.
Architectural Features of Cities and Towns during the Period of Lithuania’s Reconstruction in 1918–1925
Authors: Tranavičiūtė Brigita , Petrulis Vaidas , Laurinaitis Paulius Tautvydas , Pakštalis Arvydas 
Published: November 2022

Abstract
The purpose of this research is to disclose the architectural features of cities and towns during the period of Lithuania’s reconstruction in 1918–1925. Therefore, the features are analysed according to three criteria – the functional needs of a newly founded state, its technical capacities and stylistic preferences – by granting an acceptable stylistic shape to buildings. The results of this will help to identify the state’s functional needs in consideration of losses caused by WWI to a country that could not be reconstructed in full from the then state budget; thus, from the very beginning the focus was on reconstruction of public buildings and residential houses, out of necessity.