bluuebunny/crossref_metadata_2025_split huggingface dataset:
GOBIERNO CORPORATIVO EN MERCADOS EMERGENTES: IMPACTO EN LA BOLSA DE VALORES DE LIMA - BVL
Authors: Burneo Kurt , Lizarzaburu Edmundo R 
Published: November 2022

En la actualidad, el panorama financiero internacional ha sufrido diversos acontecimientos con implicancias sistémicas, tales como, la crisis financiera del 2007 y 2008, la desaceleración de China (del 2014 a la fecha), la contracción de los BRICS (del 2013 a la fecha), entre otras, como lo fundamental en el devenir de las economías es la performance de las firmas, ocurre que detrás de estos eventos suceden varios factores, siendo uno de ellos, la poca implementación de buenas prácticas o gobierno corporativo y esto ha llevado a que la comunidad internacional ponga énfasis en las formas de llevar a cabo transacciones comerciales. NGuyen & Xiangkang (2015), afirman que la principal prueba de los efectos de no aplicar buenas prácticas de gobierno corporativo, se evidencian de forma tangible en aquellas naciones que actualmente han visto multiplicada su productividad, ya afectada por la Crisis Subprime. Este trabajo tiene por objeto el tratar de responder a la pregunta de si verdaderamente la aplicación de los principios del Buen Gobierno Corporativo tendría como efecto, resultados diferenciadamente favorables respecto a aquellas entidades que no aplicaron estos.
A mobile app for dyslexia biomarker detection in children at home or at school: Feasibility, Acceptability, Economic impact, Pilot Study and Survey Results
Authors: Eroglu Gunet , Köprülü Mertali , Karabacak Berdan 
Published: November 2022

Dyslexia awareness is not high in societies. Although 10% of the population is thought to be dyslexic in every society, only 0.05 % of the population gets a formal diagnosis in Turkey. The financial situation of families of children with dyslexia is mostly not very good to investigate new rehabilitation opportunities. Mobile apps have been used to diagnose health conditions in recent years. Worldwide solutions for dyslexia do not exist as the solutions were language-dependent. We need an easily reachable, affordable, and worldwide acceptable biomarker detection app for dyslexia at schools because it potentially helps to prevent severe consequences through an early diagnosis that helps provide early intervention. No other research assessed the feasibility and acceptability of using this mobile app to detect dyslexia at home or school. Here we present a dyslexia biomarker detection app based on Z-scored QEEG data that can be used at home or school and has accomplished a high accuracy rate in diagnosing dyslexia. The mobile app can be used at home by parents or teachers at school. We have collected data from 207 children (96 of them have dyslexia, 111 of them are typically developing) between 7-10 years old for 60 sessions. The data consists of the eyes-open resting state 2-minute QEEG data from 14-channels. Using the ANN machine learning method, children with dyslexia/ typically developing children (TDC) classification has been done with a high accuracy rate (98.8%). ANN yields the highest accuracy results with standardized QEEG data in the literature. A survey is created to assess the dyslexia biomarker detection app’s feasibility, acceptability, and economic impact. The results have shown that the biomarker detection app is found feasible and acceptable by families, however, it is found expensive to use at home as it includes the costly EEG headset. So, in order for this biomarker detection method to be used extensively at home, EEG headset prices should become more affordable or this dyslexia biomarker detection method can be used at schools.
Incidence of Otolaryngological Diseases in General Population: A Study in Eastern Medical College Hospital
Authors: Alam Anwar Ul , Ullah Md Kalim , Shakil Mohammad , Rahman SM Tauhidur , Ahamed Mohammad Khaza , Sarower Mohammad Golum 
Published: November 2022

Background: Otolaryngological diseases are serious public health problems affecting all age groups. This includes problem of hearing, speech, phonation, breathing, swallowing, smell & taste and protection of lower respiratory passage.
Objective: The aim of this study was to determine the common clinical presentation and socio demographic characteristics of the patients attending in ENT outdoor.
Method: This cross-sectional study was conducted among 500 patients attending in ENT outdoor in Eastern medical college Hospital, Cumilla, Bangladesh using a self-administered semi-structured questionnaire from July 2020 to September 2020.
Result: In this study 44.8% were male and 55.2% female. All age group were included and majority of patients were age group of 21-30 years (28.6%). In our study 38.2% (191) of the study populations were suffering from ear diseases, and then followed by 32% (160) nose diseases and 29.8% (149) throat diseases. Common ear, nose, throat diseases were suppurative otitis media 30.37% (58), allergic rhinitis 23.13% (37), tonsillitis 31.54% (47), respectively.
Conclusion: Our study provides basic information of the incidence of ENT disorders in the study area suggests that suppurative otitis media, tinnitus, foreign body ear, allergic rhinitis, nasal polyp, sinusitis, tonsillitis and pharyngitis are the most common Otolaryngological (ENT) problems in general population visiting the ENT Department of this hospital and contribute significantly to morbidity.
EMCJ. January 2022; 7(1): 6-10
Assessment of Difficulties in Breastfeeding in Infants below 6 months of Age
Authors: Sultana Shamima , Sufian Abu , Rahman Saida Binte , Hossain Salma , Kabir Farzana , Das Joyshree 
Published: November 2022

Background: Breast milk is very much essential for proper growth, development and wellbeing of children. They should be breastfed within 1 hour of birth, exclusively breastfed for first six months of life. Breastfeeding difficulties are common. Maternal, infant and social factors are involved in establishment of proper breastfeeding.
Objective: To find out the difficulties that a mother face during breastfeeding.
Methodology: Cross-sectional observational study was carried out Shaheed Suhrawardy Medical Collage & Hospital (Sh.S.MCH). All children upto 6 months of age and their mother attending in OPD, Breast feeding corner and pediatrics indoor of Sh.S.MCH during study period.
Results: Total 19 (38%) infants had difficulty in breast feeding related to maternal factors. Majority (63%) of mother complained of not enough milk, but urine output of infants was ≥6 times within 24 hours in 7 infants of these mothers. Three mothers had stopped breast feeding due to sickness. Total 25 (50%) infants had difficulty in breast feeding related to infant factors. Majority 17 (68%) of them were crying babies, but urine output was ≥6 times in 24 hours in 12 of these infants. Refusal of breast was found in 6 (24%) infants, sickness was cause for stopping breastfeeding found in 2 (8%) infants. Total 13 (26%) infants had difficulty in breast feeding related to social factors. Majority 8 (67%) were working mother and 5 (33%) mothers said that there was lack of familial support.
Conclusion: Most of the mothers initiated breast feeding 1 hour after birth. Most of the mothers had given honey as prelacteal feeding to their infants. Most of them were on partial breast feeding. Sixty five percent infants were given formula milk. Difficulties in breast feeding were related to infant factors and maternal factors mostly. More than one factor was present in some infant.
EMCJ. January 2022; 7(1): 11-14
Effect of myopia and astigmatism deepening on the corneal biomechanical parameter stress-strain index in individuals of Chinese ethnicity
Authors: Liu Yan , Pang Chenjiu , Ming Shuai , Fan Qi 
Published: November 2022

Purpose: To investigate the differences in corneal biomechanical parameter stress–strain index (SSI) among different degrees of myopic eyes in Chinese individuals and to analyze the relevant factors of the SSI.Methods: This study analyzed the right eyes of 240 participants (240 eyes) aged 18–34 years. The participants were divided into low-, moderate-, high-, and ultra-high myopia groups according to their spherical equivalent (SE), with 60 eyes included in each group. Spherical, cylinder, and SE were measured via automatically integrated optometry. Intraocular pressure (IOP) was measured using a non-contact tonometer. AL was measured using an IOLMaster device. Corneal curvature and central corneal thickness (CCT) were measured using a Pentacam. SSI and biomechanical corrected IOP (bIOP) were measured via corneal visualization Scheimpflug technology (Corvis ST). The statistical analyses included one-sample Kolmogorov–Smirnov tests and normal distribution histogram methods, Levene variance homogeneity tests, Pearson’s correlation analyses, multiple linear stepwise regression analyses, one-way ANOVA, and LSD t-tests.Results: The mean (±SD) age of the 240 participants was (24.97 ± 4.16) years. The SSI was positively correlated with spherical, cylinder, SE, CCT, IOP, and bIOP and negatively correlated with K1 and AL (r = 0.475, 0.371, 0.497, 0.169, 0.291, 0.144, −0.154, and −0.464, respectively; all p &lt; 0.05), but were not correlated with age, K2, or Km (all p &gt; 0.05). Multiple linear regression analysis performed with SSI as the dependent variable, and spherical, cylinder, K1, CCT, and IOP as independent variables produced the following regression equation: SSI = 0.989 + 0.017 spherical + 0.042 cylinder +0.018 IOP (R2 = 0.402, F = 31.518, p &lt; 0.001). The SSI values in the low-, moderate-, high-, and ultra-high myopia groups were 0.945 ± 0.135, 0.940 ± 0.128, 0.874 ± 0.110, and 0.771 ± 0.104, respectively. The values decreased sequentially, and the differences between pairs were statistically significant (all p &lt; 0.05), except for that between the low- and moderate-myopia groups (p &gt; 0.05).Conclusion: SSI decreased with increasing myopia and astigmatism in the Chinese participants. The SSI was significantly lower in high and ultra-high myopia, especially ultra-high myopia. These findings indicate that increased corneal elasticity may be related to the pathogenesis of high and ultra-high myopia.
AAV process intensification by perfusion bioreaction and integrated clarification
Authors: Mendes João P. , Fernandes Bárbara , Pineda Earl , Kudugunti Shashi , Bransby Mike , Gantier René , Peixoto Cristina , Alves Paula M. , Roldão António , Silva Ricardo J. S. 
Published: November 2022

Adeno-associated viruses (AAVs) demand for clinical trials and approved therapeutic applications is increasing due to this vector’s overall success and potential. The high doses associated with administration strategies challenges bioprocess engineers to develop more efficient technologies and innovative strategies capable of increasing volumetric productivity. In this study, alternating tangential flow (ATF) and Tangential Flow Depth filtration (TFDF) techniques were compared as to their potential for 1) implementing a high-cell-density perfusion process to produce AAV8 using mammalian HEK293 cells and transient transfection, and 2) integrating AAV harvest and clarification units into a single step. On the first topic, the results obtained demonstrate that AAV expression improves with a medium exchange strategy. This was evidenced firstly in the small-scale perfusion-mocking study and later verified in the 2 L bioreactor operated in perfusion mode. Fine-tuning the shear rate in ATF and TFDF proved instrumental in maintaining high cell viabilities and, most importantly, enhancing AAV-specific titers (7.6 × 104 VG/cell), i.e., up to 4-fold compared to non-optimized perfusion cultures and 2-fold compared with batch operation mode. Regarding the second objective, TFDF enabled the highest recovery yields during perfusion-based continuous harvest of extracellular virus and lysate clarification. This study demonstrates that ATF and TFDF techniques have the potential to support the production and continuous harvest of AAV, and enable an integrated clarification procedure, contributing to the simplification of operations and improving manufacturing efficiency.
Multicolor flow cytometry on pericardial effusion for a prompt diagnosis and treatment of hematological malignancies with heart involvement
Authors: Cappannoli Luigi , Imazio Massimo , Hohaus Stefan , Saponara Gianluigi , D’Amario Domenico , Bellesi Silvia , Maiolo Elena , Viscovo Marcello , Fatone Federica , Alma Eleonora , D’Alò Francesco , Crea Filippo , Sanna Tommaso 
Published: November 2022

BackgroundMalignancies represent 15–50% of total causes of pericardial effusions (PE). Routine analyses recommended to be performed on pericardial fluid include general chemistry, cytology, polymerase chain reaction, and microbiological cultures. Multicolor flow cytometry (FC) is a laboratory test that already proved to be useful in the detection of lymphoproliferative and metastatic malignancies in pleural and peritoneal effusions, but current guidelines do not mention its use on PE to reach a diagnosis.MethodsOur institutional protocol foresees to routinely perform a multicolor FC analysis on pericardial fluid samples obtained by pericardiocentesis, in addition to other guidelines-recommended analyses. A sample of 15–30 ml is analyzed using a lyse and wash staining method using combination panels of antibodies, allowing to detect specific cellular subpopulations, analyzing tens to hundreds of thousands of cells in few seconds. The present manuscript aims to report our single-center experience with this diagnostic tool in patients presenting with PE requiring pericardiocentesis.ResultsRoutine use of multicolor FC on pericardial fluid samples in our institution allowed to reach a definite diagnosis of cardiac lymphomas in two patients presenting with otherwise unexplained severe PE. This resulted in immediate start of combined immunotherapy, with patients’ clinical improvement. At 6 months follow-up both patients are alive and presented a complete disease regression.ConclusionPreliminary evidence from routine use of multicolor FC on PE support that this is a promising tool to reach a rapid diagnosis of hematological malignancies with heart involvement, leading to a prompt initiation of targeted therapies.
Vein morphometry in end-stage kidney disease: Teasing out the contribution of age, comorbidities, and vintage to chronic wall remodeling
Authors: Labissiere Xochilt , Zigmond Zachary M. , Challa Akshara , Montoya Christopher , Manzur-Pineda Karen , Abraham Amalia , Tabbara Marwan , Salama Alghidak , Pan Yue , Salman Loay H. , Yang Xiaofeng , Vazquez-Padron Roberto I. , Martinez Laisel 
Published: November 2022

BackgroundChronic kidney disease (CKD) is a highly comorbid condition with significant effects on vascular health and remodeling. Upper extremity veins are important in end-stage kidney disease (ESKD) due to their potential use to create vascular accesses. However, unlike arteries, the contribution of CKD-associated factors to the chronic remodeling of veins has been barely studied.MethodsWe measured morphometric parameters in 315 upper extremity veins, 131 (85% basilic) from stage 5 CKD/ESKD patients and 184 (89% basilic) from non-CKD organ donors. Associations of demographic and clinical characteristics with intimal hyperplasia (IH) and medial fibrosis were evaluated using multivariate regression models.ResultsThe study cohort included 33% females, 30% blacks, 32% Hispanics, and 37% whites. Over 60% had hypertension, and 25% had diabetes independent of CKD status. Among kidney disease participants, 26% had stage 5 CKD, while 22 and 52% had ESKD with and without history of a previous arteriovenous fistula/graft (AVF/AVG), respectively. Intimal hyperplasia was associated with older age (β = 0.13 per year, confidence interval [CI] = 0.002–0.26), dialysis vintage &gt; 12 months (β = 0.22, CI = 0.09–0.35), and previous AVF/AVG creation (β = 0.19, CI = 0.06–0.32). Upper quartile values of IH were significantly associated with diabetes (odds ratio [OR] = 2.02, CI = 1.08–3.80), which demonstrated an additive effect with previous AVF/AVG history and longer vintage in exacerbating IH. Medial fibrosis also increased as a function of age (β = 0.17, CI = 0.04–0.30) and among patients with diabetes (β = 0.15, CI = 0.03–0.28). Age was the predominant factor predicting upper quartile values of fibrosis (OR = 1.03 per year, CI = 1.01–1.05) independent of other comorbidities.ConclusionAge and diabetes are the most important risk factors for chronic development of venous IH and fibrosis independent of CKD status. Among kidney disease patients, longer dialysis vintage, and history of a previous AVF/AVG are strong predictors of IH.
Large-scale correlation analysis of deep venous thrombosis and gut microbiota
Authors: Yang Mingyi , Luo Pan , Zhang Feng , Xu Ke , Feng Ruoyang , Xu Peng 
Published: November 2022

ObjectiveAlthough previous studies have shown that gut microbiota may be involved in the occurrence of deep venous thrombosis (DVT), the specific link between the two remains unclear. The present study aimed to explore this question from a genetic perspective.Materials and methodsGenome-wide association study (GWAS) summary data of DVT were obtained from the UK Biobank (N = 9,059). GWAS summary data of the gut microbiota were obtained from the Flemish Gut Flora Project (N = 2,223) and two German cohorts (FoCus, N = 950; PopGen, N = 717). All the participants were of European ancestry. Linkage disequilibrium score (LDSC) regression has great potential for analyzing the heritability of disease or character traits. LDSC regression was used to analyze the genetic correlation between DVT and the gut microbiota based on the GWAS summary data obtained from previous studies. Mendelian randomization (MR) was used to analyze the genetic causal relationship between DVT and the gut microbiota. We used the random effects inverse variance weighted, MR Egger, weighted median, simple mode, and weighted mode to perform MR analysis. We performed a sensitivity analysis of the MR analysis results by examining heterogeneity and horizontal pleiotropy.ResultsLinkage disequilibrium score analysis showed that Streptococcaceae (correlation coefficient = −0.542, SE = 0.237, P = 0.022), Dialister (correlation coefficient = −0.623, SE = 0.316, P = 0.049), Streptococcus (correlation coefficient = −0.576, SE = 0.264, P = 0.029), and Lactobacillales (correlation coefficient = −0.484, SE = 0.237, P = 0.042) had suggestive genetic correlation with DVT. In addition, the MR analysis showed that Streptococcaceae had a positive genetic causal relationship with DVT (P = 0.027, OR = 1.005). There was no heterogeneity or horizontal pleiotropy in the MR analysis (P &gt; 0.05).ConclusionIn this study, four gut microbes (Streptococcaceae, Dialister Streptococcus, Lactobacillales) had suggestive genetic correlations with DVT, and Streptococcaceae had a positive causal relationship with DVT. Our findings provide a new research direction for the further study of and prevention of DVT.
The impact of direct oral anticoagulants on viscoelastic testing – A systematic review
Authors: Sahli Sebastian D. , Castellucci Clara , Roche Tadzio R. , Rössler Julian , Spahn Donat R. , Kaserer Alexander 
Published: November 2022

BackgroundIn case of bleeding patients and in acute care, the assessment of residual direct oral anticoagulant (DOAC) activity is essential for evaluating the potential impact on hemostasis, especially when a timely decision on urgent surgery or intervention is required. Viscoelastic tests are crucial in a modern goal-directed coagulation management to assess patients’ coagulation status. However, the role of viscoelastic test to detect and quantify residual DOAC plasma levels is controversially discussed. The aim of this review was to systematically summarize the evidence of viscoelastic tests for the assessment of residual DOAC activity.MethodPubMed, Embase, Scopus, and the Cochrane Library were searched for original articles investigating the effect of rivaroxaban, apixaban, edoxaban, or dabigatran plasma levels on different viscoelastic tests of the adult population from database inception to December 31, 2021.ResultsWe included 53 studies from which 31 assessed rivaroxaban, 22 apixaban, six edoxaban, and 29 dabigatran. The performance of viscoelastic tests varied across DOACs and assays. DOAC specific assays are more sensitive than unspecific assays. The plasma concentration of rivaroxaban and dabigatran correlates strongly with the ROTEM EXTEM, ClotPro RVV-test or ECA-test clotting time (CT) and TEG 6s anti-factor Xa (AFXa) or direct thrombin inhibitor (DTI) channel reaction time (R). Results of clotting time (CT) and reaction time (R) within the normal range do not reliable exclude relevant residual DOAC plasma levels limiting the clinical utility of viscoelastic assays in this context.ConclusionViscoelastic test assays can provide fast and essential point-of-care information regarding DOAC activity, especially DOAC specific assays. The identification and quantification of residual DOAC plasma concentration with DOAC unspecific viscoelastic assays are not sensitive enough, compared to recommended anti-Xa activity laboratory measurements.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=320629], identifier [CRD42022320629].
Exothermic characteristics research of chemical self-heating solution in the gas hydrate exploitation process
Authors: Zheng Xuzhong , Wu Dan , Zhou Bo , Wang Zhuangyin , Liu Li , Yu Junchao , Yuan Qing , Jiang Song , Zhao Jiamin , Wang Yue 
Published: November 2022

Thermal stimulation methods of hydrate exploitation with chemical self-heating solution began to be investigated in the recent years. However, the exothermic characteristics of chemical self-heating solution during the gas hydrate exploitation process was not investigated systematically now. In this work, the effects of reagent concentration, acid variety, acid concentration on the exothermic characteristics were investigated by a self-designed high pressure autoclave with a 11.75 L volume, whose diameter and length is 100 and 1,500 mm, respectively. The experimental results showed that the temperature of hydrate reservoir will change in a wide range (from 100°C to −3°C) during the injection process of self-heating solution which was a large challenge to control the rate of heat release. During the self-heating solution injection, the temperature decreased quickly because of the strong endothermic reaction of hydrate dissociation promoted by the salt effect of self-heating solution, and then the temperature increased quickly because of exothermic reaction of self-heating solution. The exothermic rate of self-heating solution increased with the increase of reagent concentration, the acid concentration and the acidity. In all of the experiments, the temperatures near the inlet entrance were much higher than that in the deeper area, which illustrated that the effective heating area is the areas near the entrance. In the end, the different injection mode of mixed injection and sectional injection was also investigated, and it was found that the temperature peak in the near area with mixed injection mode is higher than that with sectional injection mode, however, the exothermic performance with sectional injection mode is better than that with mixed injection in the area far away from the inlet entrance. The exothermic characteristics studies of self-heating solution in this work can lay the necessary foundation of the further studies of self-heating solution in the exploitation of natural gas hydrate.