bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silver Sulfadiazine: Action on Burn Wound Sepsis and Infections
Authors: Walia Satwinder Singh , Prasad D.N. 
Published: July 2022

The purpose of this systematic review and meta-review has shifted from assessing the consequences of silver sulfadiazine with most different drugs (SSD) for burn recovery and contamination prevention to different novel dressings, without or with silver. Burn units have to be able to better control sepsis. The degree to which a burn topical antibacterial agent is absorbed determines its effectiveness. Absorption of a topical antibacterial agent may be evaluated against the absorption of a test solute in isolated preparation of the stratum corneum in a cell in an in vitro model. Despite the fact that adding silver sulfadiazine (AgSu) to pure deoxyribonucleic acid (DNA) resulted in the formation of silver sulfadiazine (AgSu)the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. In treated bacteria, AgSu inhibited macromolecular syntheses as DNA synthesis was slightly more sensitive. A tiny amount of sulfadiazine appears to be active in this situation. Pediatric patients were randomly assigned to treatment with either Silva-Sorb® Gel or Silvadene® silver sulfadiazine cream for up to 21 days or to the point of full reepithelialization of the wound.
Keyword: Silver, Sulfadiazine, Silvasorb, Bacteria, Burn, Wound.
Tumor Biology; Usefulness of Thermosensitive and pH Sensitive Polymeric Nanoparticles for Tumor Targeting: A Review
Authors: Banda Srikanth 
Published: July 2022

Polymeric nanoparticles (PNPs) have attracted the interest of many scientists and have been utilized in an increasing number of fields during the last two decades. The conventional chemotherapeutic agents have poor pharmacokinetic parameters such as non-specific distribution of drugs, the lack of drug specific affinity towards a pathological site, and thus necessitating large dose of a drug to achieve high local concentration in the body leading to systemic toxicity associated with serious side effects. A thorough and precise understanding of tumor microenvironment such as angiogenesis, tumor pH, enhanced permeation and retention (EPR) effect, abnormal lymphatics, multidrug resistance (MDR) and high interstitial fluid pressure, allows designing drug delivery systems that specifically target anti-cancer drugs to tumors. An attempt has been made in this article to highlight the temperature and pH sensitive PNPs, and PNPs with dual and double response to both temperature and pH that have a distinct capacity to target tumors with limited effect on healthy tissues. The stimuli responsive nanoparticles are classified based on their mechanism of response to temperature and pH. Structure of the polymer, methods of drug loading, and characterization of PNPs are elucidated.
Keywords: Polymeric nanoparticles; pH sensitive polymers; Thermosensitive polymers; Tumor microenvironment; Multidrug resistance; Drug loading.
A review on Advanced approaches and polymers used in gastroretentive drug delivery systems
Authors: Varshi Reena , Jain Vikas , Pal Pradeep 
Published: July 2022

Insufficient pharmacokinetic characteristics may be associated with the widespread use of oral dosage forms in the treatment of disease. In some cases, the drug is barely soluble; in others, the formulation's rapid transit through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in body; in addition, some drugs must act locally due to a gastric pathology, but they remain in the stomach for only a short time. Numerous studies have focused on the development of formulations that are capable of enhancing all of these characteristics and extending the stomach residence duration. The prolonged stomach retention duration afforded by gastroretentive controlled drug delivery devices increases the therapeutic efficacy of many orally administered drugs. In the present investigation, we reviewed the advanced methods and polymers used to develop effective gastroretentive drug delivery systems. These methods include swelling and expansion, mucoadhesive, high density, low density, ion exchange, raft forming, magnetic, and floating drug delivery systems. The development of gastroretentive devices involves a broad array of polymeric materials. This work intends to expedite the development of innovative methods by offering a comprehensive understanding of unique gastroretentive approaches along with the polymeric materials utilised in the fabrication of gastroretentive drug delivery systems for oral drug delivery.
Keywords: Gastroretentive; mucoadhesive; floating; raft forming system; mucoadhesive; swellable.
Preparation of Luliconazole loaded silver nanoparticles Topical gel
Authors: Kumar Ajay , Soni Abhishek , Kumar Ashish , Yashpal , , Devi Jyoti 
Published: July 2022

After optimization of the luliconazole loaded silver nanoparticles formulation it was given a gel base for topical delivery the silver nanoparticles have a very low viscosity. The gel was formed by varying the concentration of carbopol 940 as 0.75%, 1. %, 2%. The optimized luliconazole loaded silver nanoparticles formulation LSN14 was incorporated into different concentration carbopol gel base of different concentrations of carbopol and evaluated for various in vitro characterization parameters homogeneity, grittiness, measurement of pH, drug content, viscosity study, Spreadibility, in - vitro drug release studies and drug release kinetics. All prepared gel formulation having different concentration of carbopol was homogenous and uniform in appearance and free from grittiness except the formulation LSN14G1Have not sufficient thickness and thus it was not used further evaluation. On the basis of result of above parameters LSN14G3 was selected for further in-vitro drug release study. Comparison of In vitro Percentage drug release study of Control gel of Luliconazole and luliconazole loaded silver nanoparticle gel formulations LSN14G3 and in - vitro drug release profile the Percentage drug release of prepared silver nanoparticle gel was found to be higher in sustained manner93.36±0.56 after 24 hr as compare to control gel 38.50±1.21.
Keywords: optimization, silver-nanoparticles, carbopol, kinetics, luliconazole
Highly Promising an Anti-Cancer Drugs : Metal Complex Bearing Sulfur Chelating Ligand, A Hypothetical Design
Authors: Sarkar Sanchita , Sarkar Shuranjan , Ahmed Zakaria 
Published: July 2022

In anticancer chemotherapy, drug targeting and delivery methods depend on agents with selective access to cancer cells to deliver drugs to the target, and approaches to finding such agents often depend on novel design strategies employing bioactive vectors. Platinum-based complexes are extremely important drugs for the treatment of cancer. Recently synthesized complexes of Pt (IV) have been shown to have several advantages, such as they are safer, can be used orally, are highly anti-cancer effective, there is no cross-resistance to cisplatin, and their effectiveness is compared with commonly used Pt (II) compounds such as cisplatin and oxaliplatin. A molecular mimicry model for the generation of new active drugs may be synthesized by the 3,5-ditert-butyl-2-hydroxy-benzylaminocysteine (DTHBAC) where a cysteine group and two tertiary butyl groups attached to the phenol aromatic ring can be coordinated with platinum. This appropriate ligand with the platinum complex is fit for the anticancer drug. Based on the present modeling, it can be recommended in the management of patients, and from this perspective, the status of the platinum anticancer drug field will develop over the next decade. Moreover, the authors have no doubt that this will benefit patients in the future and will be widely used in cancer treatment for years to come.
Keywords: Drug design, Anti-cancer, Cisplatin, Complex, Chelate.
An Overview on Dementia: A Major Symptom of Alzheimer's Disease
Authors: Kaur Jaspreet , Melkani Indu , Singh Ajeet Pal , Singh Amar Pal , Bala Kiran 
Published: July 2022

Dementia is a word for an acquired illness in which two or more cognitive abilities are lost due to a brain disease or injury. The most common form of dementia is Alzheimer's type dementia (DAT). It has been associated to cerebral cortical degenerative anomalies. It's also visible in neurologic diseases that primarily affect subcortical systems such as the basal ganglia and brain stem. The causes are plaques of β-amyloid and tangles of intraneuronal tau protein. Dementia is addressed in this overview. Pathophysiology, epidemiology, and different varieties of dementia; contributing factors to dementia; symptoms, causes, diagnosis, prevention, and care; and new breakthroughs in dementia treatment. It also looks at how patients with mental problems coped during the COVID-19 outbreak. Patients may require more therapies to manage their illness, and some future drugs are now being explored.
Keywords: Dementia, Alzheimer's, Plaques, Cognitive training, β-amyloid
Traditional uses, Pharmacology and Phytochemistry of National flower of Nepal Rhododendron arboreum: A Review
Authors: Ahmad Md. Parwez , Ali Sheeza , Wahab Shadma , Perween Tarannum , Shahzad Naiyer , Dhami Dabal Bahadur 
Published: July 2022

Methods: This review provides scientific grounds in the literature for the phytochemical and pharmacological activities of Rhododendron arboreum, from 2010- 2021. Chiefly three bibliographic databases were used as the main sources of information (Google scholar, PubMed, and Science Direct). The keywords used in this research are as follows: “Phytochemical”, “National flower”, “Bioactive compounds”, “Pharmacology” and “Rhododendron arboreum”.
Results: Various studies were included in this review according to the required criteria, including phytochemical and traditional uses. Rhododendron arboreum contains flavonoids alkaloids, terpenoids, glycosides, steroids, anthraquinones, saponins and tannins. Pharmacological and traditional uses of this plant on the basis of presence of above active ingredients.
Keywords: Bioactive compounds, National flower, Rhododendron arboreum
Review: The Effectiveness of Using Vitamins in Pregnant Women as Prevention of Pre-eclampsia
Authors: Kamri Andi Maulana , Kosman Rachmat , Putra Bayu 
Published: July 2022

Nutrients needed by pregnant women are high. The variety of vitamins consumed early in pregnancy can affect the condition and growth and development of the baby and the health of pregnant women. The incidence of pre-eclampsia is one of the things that most often appears in pregnant women who are at risk for mothers and newborns. This study will look at vitamins that play an important role in preventing the occurrence of pre-eclampsia. The study used the PICO method in search and assessment of 13 articles obtained from the PubMed and Research Gate databases. Some of the vitamins needed by pregnant women include calcium, folic acid, iron, mecobalamin, zinc, vitamins A, E, and pyridoxine. All vitamins have a positive effect on pregnant women in supporting growth and also maintaining the health of pregnant women. Folic acid and calcium play an important role in maintaining blood pressure. This is related to the presence of homocysteine ​​and endothelial dysfunction that occurs in the first and second trimesters. Zinc itself has a role in maintaining mental health which usually occurs due to premenstrual syndrome and also pregnancy in the early trimester. This is because of blood pressure disorders due to mental health. However, there is nothing that shows a relationship with the incidence of pre-eclampsia. The most important vitamins for maintaining blood pressure during pregnancy are folic acid and calcium.
Keywords: Vitamins, Pregnant, Pre-eclampsia, Preterm Birth, Effectiveness.
Therapeutic potential of Murmakki (Commiphora myrrha) in gynaecological disorder: A Unani review
Authors: Shazamani S , Begum Wajeeha , Sumaiya Syeda 
Published: July 2022

Murmakki is a well-known and potent herbal drug used in various traditional medicines for its various beneficial effects on different Gynaecological ailments and diseases. It is commonly known as Gum Resin. It Consists of oleogum resin obtained by exudation from the stem of a plant of Commiphora myrrha. It is used in Saudi Arabia, Indian and Western Medicine and is listed in the British pharmacopoeia as an antispasmodic and expectorant. In ancient traditional Persian manuscripts, it has been noted that myrhh acts as a uterine stimulant and probably cause complete abortion. In Unani Medicine, it is used as a potent drug for dysmenorrhea and amenorrhea as mentioned by Avicenna and Razi in their treatises. This review article discusses the pharmacognosy, phytotherapy, phytochemical and biological studies of Commiphora myrrha along with a comprehensive review based on Unani Medicine.
Keywords: Murmakki, Commiphora myrrha, Oleo gum resin, Gynaecological disorders.
The Chemical and Pharmacological Advancements of Quinoline: A Mini Review
Authors: Bharti Anurag , BIJAULIYA ROHIT KUMAR , Yadav Anita , Suman , 
Published: July 2022

Quinoline is a preferred scaffold that emerges as a prominent assembly motif for the creation of novel pharmacological molecules among heterocyclic compounds. An important family of chemicals includes quinoline and its derivatives that have been studied for various biological activities. Due to its wide range of bioactivity, quinoline, which is made up of benzene fused with N-heterocyclic pyridine, has drawn a lot of interest as a key template in drug creation. In order to demonstrate the quinoline motifs' significant efficacies for upcoming drug development, this review intends to provide the most current developments in chemistry, their medicinal potential, and their pharmacological applications. As a result, these compounds have been produced by several scientific groups as intentional structures, and their biological functions have been examined. The current study offers succinct information on quinoline's natural sources, as well as details on newly marketed medications that include quinoline. The pharmacological effects of quinoline derivatives, such as their anticonvulsant, antibacterial, antiviral, anti-protozoal, antimalarial, anticancer, anti-inflammatory, and anthelmintic properties, are also discussed in this study.
Keywords: Nitrogen-Based Heterocycles, Quinoline, Synthesis, Biological Activities
Assessing service providers’ satisfaction with the chronic diseases package provided through the National Health Insurance Fund in Sudan
Authors: Fakihammed Wael A. , Hussien Rehab A. , Atbara Zohal B. Ahmed , Higaz Shiraz O. , Mirghani Ashwag A. , Elkhatim Osama E. Sir , Abdalla Moneer A. , Hammad Almoeiz Yousif 
Published: July 2022

Background: The prevalence and burden of chronic diseases is growing significantly with direct impact on health and financial security of population. In Sudan, there is a continuous effort to improve access for good and integrated health services but still the utilization of these services is low. Therefore, there is an urgent need to assess the availability and integration of benefit package to ensure better and effective coverage of services.Aim: This is a descriptive cross sectional based study aimed to assess the opinion of service providers about the chronic diseases package provided through the national health insurance fund.Methods: Form390 participating, data was collected via closed ended standardized questionnaires. Pre testing was done to ensure quality survey instruments and fieldwork procedures were conducted. A structured questionnaire with closed-ended questions was developed based on literature and previous studies. The questionnaire made up of 30 questions and organized in the following sections: background characteristics, medical characteristics, health professionals’ knowledge and practice related to NHIF ’chronic diseases package and perception about NHIF ‘chronic diseases package.Results: Our results showed that despite the existence of a number of issues, the National Health Insurance Fund is rather accepted amongst our respondents. Issues manifested were in regards to health education and supply issues of drugs. Conclusion: Our study concluded that, there is an obvious weakness in both training of providers and implementation of national protocols for chronic diseases. Moreover, despite the challenges of drug availability, 70% of our participants expressed positivity when questioned about the presentation of the drug package, bearing in mind the importance of reviewing the list to ensure its inclusion of new items. There is a need for training medical providers about chronic diseases with more focusing on health promotion and application of national guidelines. Additionally, integration of chronic diseases services in necessary for achieving universal health coverage.
Keywords: national protocols for chronic diseases, national health insurance fund, health promotion
Evaluation of Prescription Pattern and Medication Adherence in Patients with Alcoholic Liver Disease
Authors: ANIL GOPIKA T , MS Gowri Sivan , SAJIKUMAR HARIPRIYA , S HONEY P , RB Mahendra , Nyamagoud Sanat B 
Published: July 2022

Background: ALD is the most common cause of morbidity and mortality among patients. A patient’s Medication Non-Adherence may also interfere with the progression of Disease. Analysis of Prescription pattern in ALD helps to ensure the safety of the Patient by assessing the signs and symptoms of disease and its appropriate therapy. Thus, educating the patients regarding their clinical condition will have a significant role in reducing the severity of the disease. Aim: To assess the Prescription pattern, Medication Adherence and to identify the correlation between the medication adherence and the educational status in ALD patients. Materials and Methods: The Study was a Prospective Observational study carried out for a duration of Six months. Morisky Green Levine scale was the tool used to assess the medication adherence. Data was collected using a self-designed data collection form. Results: A Total of 160 Alcoholic subjects were assessed during the study period among which 65.62% of them were illiterate. Out of total cases 76.87 % of hepatoprotective drugs, 50.62% antiemetics, 38% vitamins and 11% of anti-ulcer drugs were prescribed among patients. It was found that there exist a relationship between educational status and medication adherence (P-value: 0.0021). Conclusion: The study helped to assess the different class of drugs, drugs used in different comorbid conditions and also to evaluate, identify and solve the problems associated with the Medication Non-Adherence of the patients.
Keywords: Medication Adherence, Alcoholic Liver Disease, Rational Drug Therapy.
How is the practice of nurses in preventing infection of central venous catheters in hospitalized patients?-Nurse knowledge and attitudes
Authors: Manurung Santa , Dewi Yupita 
Published: July 2022

Central venous catheter (CVC) is an action that is often performed in treatment. There are several indications for the installation of a central venous catheter, ranging from measurement of central venous pressure (CVP), chemotherapy to parenteral nutrition. Central venous catheter wound care that is not carried out according to the procedure can cause various complications, one of which is infection. The incidence of sepsis due to central venous catheter placement is a significant cause of morbidity and mortality for patients. All nurses are required to have good skills and attitudes in the practice of implementing central venous catheter wound care in accordance with the procedure. Objective: This study aims to analyze the relationship between knowledge and attitudes of nurses regarding wound care to nurses practice in preventing wound infections in patients with central venous catheters. Methods: The design of this study was cross sectional using a descriptive correlational design. This research was conducted in July 2020. The number of samples involved in this study were 69 nurses with Diploma III educational qualifications in the inpatient ward of Dharmais Cancer Hospital. Data analysis using chi-square. Results: Bivariate analysis showed a value of p<0.05 for nurses knowledge and attitudes regarding central venous catheter wound care on nurse practice in preventing central venous catheter infection. Conclusion: there is a relationship between the level of knowledge and attitudes of nurses in wound care to the practice of nurses in preventing wound infections in patients with central venous catheters in hospital inpatient rooms.
Keywords: Nursing knowledge, attitude, practice, infection prevention, central venous catheter.
Formulation of stick laor (Eunice viridis) as an alternative food supplement for toddlers in stunting prevention
Authors: Ristanti Ety Yuni , Asrar Muhammad 
Published: July 2022

Adequate nutrition is needed as the basic capital of the child's growth and development process, especially protein. The occurrence of malnutrition conditions will affect the achievement of perfect growth. Based on this phenomenon, it is necessary to fulfill nutritional needs, especially the consumption of foods rich in energy and protein as well as micronutrients. Local food sources of energy and protein produced from Maluku Province are enbal, laor and moringa leaves. Laor (Eunice viridis) contains 29.8% protein, contains essential and non-essential amino acids, 229.26 mg calcium, 2.439 mg zinc and 3.149 mg iron per 100 grams of laor flour. The purpose of this study was to analyze the Physicochemical and sensory evaluation of stick laor (eunice viridis) as an alternative food supplement for toddlers in stunting prevention. The research method used in the first year of research was a RAL experimental design (Completely Randomized Design) which consisted of four treatments, namely the difference in comparison with the use of 5% laor flour was coded F1, for the use of 10% laor flour was coded F2 and the use of 15% laor flour coded F3. The variables measured were levels of protein, fat, carbohydrates, energy, zinc, Fe, calcium. Organoleptic test for taste, aroma, color and texture. The results showed that the highest content of energy, protein, fat, calcium, iron and zinc was F3, F2 had the best acceptability in terms of color, taste, aroma and texture. Sticks Laor increase the intake of energy, protein, and calcium for toddlers and increase serum calcium levels.
Keywords: Sticks laor, food supplement, toddlers, stunting prevention