bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the clinical effectiveness of diagnosis and monitoring of inflammatory and destructive diseases of the oral mucosa from the standpoint of a patient-guided approach
Authors: Makedonova Yu. A. , Shkarin V. V. , Dyachenko S. V. , Gavrikova L. M. , Dyachenko D. Yu. , Zhuravlev L. V. 
Published: July 2022

At present, a significant increase in inflammatory-destructive pathologies of the oral mucosa has been revealed. However, despite the high prevalence and the trend towards a constant increase in the number of diseases, there is no single diagnostic algorithm for examining and managing these patients in dental practice. To solve the above problems, a complex system of a patient-oriented approach to the diagnosis and monitoring of the inflammatory-destructive process in diseases of the oral mucosa was developed.Aim.To evaluate the effectiveness of the developed complex system of a patient-oriented approach to the diagnosis and monitoring of inflammatory-destructive diseases of the oral mucosa.Materials and methods.A survey of 60 patients with inflammatory-destructive diseases of the oral mucosa was carried out, which were divided into 2 groups. In the main group, diagnostics and monitoring were carried out using the developed system, in the control group – according to the generally accepted scheme.Results.Taking into account the data of the study, we can confidently speak about the clinical effectiveness of the developed complex system of a patient-oriented approach to the diagnosis and monitoring of the inflammatory-destructive process in diseases of the oral mucosa. When managing patients using the proposed system, a personalized approach is provided, the dynamics of the course of the pathological process is objectively and accurately assessed, certain periods of clinical observation are offered in order to correct the prescribed therapy regimen.Conclusions.The use of a patient-oriented approach in the diagnosis and monitoring of the system helps to reduce the time of regeneration of inflammatory-destructive diseases of the oral mucosa, improves the effectiveness of the treatment of this pathology, and also improves the patient's quality of life.
Treatment of chronic periodontitis using a preparation based on plant components in an experiment
Authors: Valeeva G. A. , Haibullina R. R. , Danilko K. V. , Shangina O. R. , Gerasimova L. P. , Shamsiev M. R. , Astakhova M. I. , Galiahmetova I. A. 
Published: July 2022

Aim. Development of the chronic periodontitis treatment method using the medicamentation based on herbal components in the experiment.Materials and methods. An experimental model of chronic periodontitis was created. Mesenchymal stem cells (MSC) from the extracted retained human tooth were obtained multipotent. The obtained MSCs were injected into the periodontalpockets together with the osteogenesis stimulator drug. Then a medicamentation based on plant components was applied.Results. Periodontal pocket depth decreased to 1.5 ± 0.01 mm (P < 0.001). There was no tooth mobility. Three months after the therapeutic procedures radiographs of the rats showed signs of bone neoplasia. By 6 months these signs became more pronounced: the foci of stained osteoporosis disappeared and began to acquire a finely petrified structure, the contours of the interalveolar septa became clear and smooth with a simultaneous increase in the height of resorbed ridges of the interalveolar septa.Conclusions. Experimental studies have shown pronounced therapeutic efficacy of the method for the treatment of destructive changes of the alveolar bone in periodontitis.
Indications for treatment of rapid palatal expansion devices based on cone-beam computed tomography
Authors: Smirnova A. A. , Gavrilova O. A. , Motornova E. V. , Mikhaleva I. I. , Fedorova K. V. , Sokolova L. N. 
Published: July 2022

Currently, many orthodontists often prescribe the method of rapid palatal expansion (RPE) to patients, however, there are no clear criteria for indications for the use of the method based on cone-beam computer tomography (CBCT) in the available literature.Aim. Determination of indications for the use of the technique of rapid palatal expansion based on the data of the CBCT.Materials and methods. A retrospective analysis of control and diagnostic models and CBCT of 40 patients with diagnosed narrowing of the upper jaw was carried out. All the subjects were divided into two groups: the first was patients who were treated with RPE devices. The second is patients whose orthodontic treatment used other methods (mainly expanding removable plate apparatus or partial bracket system). The analysis of control and diagnostic models according to the Pona method and the determination of palate narrowing by CBCT were carried out. Comparison of the two groups by a quantitative indicator having a normal distribution, provided that the variances were equal, was performed using the Student's t-test, with unequal variances – Welch's t-test. The comparison of the two groups by a quantitative indicator, the distribution of which differed from the normal one, was carried out using the Mann-Whitney U-test.Results. Analysis of measurements in the area of premolars and molars by the Pona method in both groups revealed no statistically significant differences (p = 0.093, p = 0.137, respectively). However, when analyzing the indicators obtained by measuring the width of the palate at the level of the deepest points of the bone base in the projection of the Pon line, it showed the presence of statistically significant differences (p < 0.001). The following values were obtained: the average width of the palate at the molar level in patients using the RPE method was 24± 2 mm, in the second group – 30± 2 mm. At the premolar level, the average width of the palate in patients treated with the RPE method is 20 mm, in group 2–22 mm.Conclusions. With a narrowing of the palate less than 26 mm at the level of the molars and less than 20 mm in the premolar region, the use of methods of rapid palatal expansion can be shown. Further development of the methodology and indications for treatment with rapid palatal dilation devices is required.
The use of 3D technologies in the planning of orthognathic operations in patients with anomalies in the development of the jaws
Authors: Kolchin S. A. , Drobyshev A. Yu. , Kurakin K. A. , Dibirov T. M. , Miterev A. A. 
Published: July 2022

Aim. Improving the methods of planning and the surgical stage of the combined treatment of patients with jaw anomalies using 3D technologies and subsequent assessment of the accuracy of the result.Materials and methods. In the period from 2019 to 2021, 90 patients with anomalies in the development of the jaws aged 18 to 45 years were examined and treated. 45 female patients, 45 male. All patients underwent a comprehensive examination and subsequent surgical treatment. Patients were divided into 3 groups depending on the planning method.Results. When evaluating the results of the study, significant differences were found between the control group (I) and group II and the control group (I) and group III with a difference effect from medium, moderate to large, strong in 25 coordinates out of 35 (71%). There was no statistically significant difference between groups II and III. The average difference in coordinates between planned movements and postoperative results in comparison between groups I and II, groups I and III is from 0.69 mm. up to 2.14 mm. The average difference in coordinates between groups 2 and 3 is from 0.20 mm. up to 0.54 mm. The maximum differences between the planned and postoperative results were revealed in the coordinates responsible for vertical movements, as well as various angles (pitch, roll and yaw), the average deviation for all three groups was in the range from 2.02 mm to 3.13 mm. This fact led to the conclusion that 3D planning allows to achieve more predictable results in the surgical stage of the complex treatment of patients with jaw anomalies. However, for a more accurate assessment of the quality of planning, a larger sample size of patients is needed, with the possible inclusion of a larger number of reference points.Conclusions. The widespread digitalization of the medical industry has made it possible to introduce many tools aimed at increasing the accuracy of preoperative planning, as well as visualizing future changes in the patient. Three-dimensional (3D) methods of virtual visualization and planning allow you to combine information from the soft tissues of the face, skeleton and dentition. Computer simulation of operations is becoming increasingly important in the field of maxillofacial surgery, as the technology offers improved possibilities for preoperative planning and reduction of possible risk factors at the preoperative, operative and postoperative stages.
Pendampingan Pemanfaatan Marketplace Pada Generasi Muda Pelaku UMKMSebagai Upaya pemulihan Ekonomi
Authors: Novita Sari Dita , Anggie Sinthiya Ida Ayu Putu , Kusnadi Danang , Hendrawan Eko , Puastuti Dwi , Septia Nagara Erliza 
Published: July 2022

Pemulihan ekonomi negara menjadi tanggung jawab pemerintah, bersama dengan semangat masyarakat untuk memulihkan kegiatan perekonomian negaranya maka pemerintah harus memiliki komitmen mendukung segala sesuatu usaha rakyat. Maraknya pasar online atau market place di Indonesia tentunya sangat mempengaruhi kegiatan para pelaku ekonomi, karena pasar online merupakan perantara perdagangan bagi para pelaku ekonomi, baik rumah tangga keluarga, perusahaan, maupun masyarakat luar negeri dapat melakukan transaksi jual beli dengan mudah. Pekon Tulungagung merupakan bagian dari Kecamatan Gadingrejo, Kabupaten Pringsewu. Provinsi Lampung. Para pelaku UMKM yang berada dipekon Tulungagung umumnya hanya berinteraksi di pasar, adapun perkembangan teknologi yang sudah mulai digunakan adalah penjualan melalui media sosial facebook, dan whatsaap yang cakupan daerahnya masih disekitar daerah terdekat. Berdasarkansituasitersebut maka permasalahan yang terjadi adalah terbatasnya area promosi dan transaksi yang bisa diselesaikan dengan memanfaatkan marketplace sebagai upaya peningkatan pendapatan dan peluasan area promosi
Conhecimento de enfermeiros e médicos de uma microrregião do Nordeste brasileiro sobre a vacinação infantil
Authors: Bastos Jácome de Souza Isabela , Campêlo Lago Eliana , Maria Evangelista de Araújo Telma , Aparecida Pinheiro Landim Almeida Camila , Ibiapina Tapety Fabrí­cio , Lopes de Carvalho Moisés 
Published: July 2022

O objetivo foi avaliar o conhecimento de profissionais da Estratégia Saúde da Famí­lia de uma microrregião do Nordestebrasileiro sobre o calendário vacinal no primeiro ano de vida. Estudo descritivo, seccional com 33 médicos e 50 enfermeiros. Os dados foram processados pelo software Statistical Package for the Social Science versão 19. A maioria dos participantes (62,5%) afirmou não ter recebido treinamento para atuar em sala de vacina. Ao cruzar o conhecimento com a categoria profissional, verificou-se significância estatí­stica para o enfermeiro (pâ‰¤0,02). Quanto aos motivos para o adiamento e í s contraindicações, observou-se baixa porcentagem de acertos. Há necessidade de capacitar os profissionais responsáveis pelas imunizações, no sentido de assegurar os benefí­cios e a qualidade da imunização nas crianças de 1 ano.
A cidade e sua lírica geometria decorativa: patrimônio gráfico e popular, da cidade ao papel
Authors: Guimarães Goulart Fernanda , Viana Alice 
Published: July 2022

Este artigo apresenta a pesquisa A cidade e sua lírica geometria decorativa que visa a promover, através de um viés experimental e transdisciplinar, uma singular interação entre os campos da Arquitetura, das Artes Visuais e do Design Gráfico, tendo como ponto de partida os processos gráficos e de criação mobilizados pela confecção de material gráfico interativo, uma caixa que contém uma diversidade de objetos e impressos que traduzem criativamente elementos da arquitetura popular Art Déco de Belo Horizonte. Tomando como conceito operador principal a noção de "memória gráfica", aposta-se que ela seja capaz de iluminar criticamente os objetos concernentes à Arquitetura e ao Urbanismo, na medida em que diz respeito à salvaguarda, a partir das imagens, de materialidades, traços identitários e técnicas que estão desaparecendo da cidade. Objetiva-se, ainda, a partir dos vieses pragmático-experimental e teórico-crítico, fazer da obra um objeto gerador de perguntas e reflexões sobre os desdobramentos histórico-críticos para o modernismo e a identidade cultural brasileiros tangíveis ao estilo Art Déco em suas manifestações ditas populares; a presença do ornamento no espaço urbano; o modo com que os artistas e designers trabalham a memória das cidades; a prática do livro de artista como possível lugar de salvaguarda e transcriação da memória urbana.
SWOT-АНАЛІЗ ІНСТРУМЕНТАЛЬНОГО БАЗИСУ ФІНАНСОВОГО ЗАБЕЗПЕЧЕННЯ СОЦІАЛЬНОЇ СФЕРИ ТЕРИТОРІАЛЬНИХ ГРОМАД
Authors: Дорош Вікторія  , Московчук Алла  
Published: July 2022

Стаття присвячена виявленню ефективних інструментів фінансового забезпечення соціальної сфери територіальних громад України.
Теоретичною основою проведеного дослідження стали наукові праці провідних вітчизняних вчених з питань фінансового забезпечення соціальної сфери територіальних громад України в умовах децентралізації, методологічним базисом – загальнонаукові та спеціальні методи, зокрема аналіз, синтез та порівняння.
Дослідження емпірично підтверджує та теоретично доводить важливість нарощення фінансового забезпечення громад. Це означає, що влада на місцях має сприяти процесам децентралізаційної трансформації. Контроль потреб територіальних громад необхідно здійснювати через завчасне виявлення даних потреб та пошук джерел їх фінансування для нівелювання пертурбацій окремо взятої місцевості.
Розглянуто зміст та значення кожного з інструментів фінансового забезпечення соціальної сфери територіальних громад України. Визначено зміст досліджуваних інструментів, ідентифіковано форми їх реалізації, проведено SWOT-аналіз інструментальної бази фінансового забезпечення соціальної сфери територіальних громад. Побудована матриця SWOT-аналізу розмежована на досліджувані інструменти: місцеві запозичення, корпоратизація комунальних підприємств, гранти, міжмуніципальне співробітництво, фінансування проєктів коштом Державного фонду регіонального розвитку (ДФРР), отримання додаткових надходжень у вигляді процентних доходів, субвенція на соціально-економічний розвиток окремих регіонів.
Результати дослідження можуть бути корисними в процесі розробки науково-обґрунтованих рекомендацій щодо удосконалення інструментів фінансового забезпечення соціальної сфери територіальних громад України.
ФІНАНСОВА БЕЗПЕКА БАНКІВ: РЕАЛІЇ ТА ПЕРСПЕКТИВИ ЗАБЕЗПЕЧЕННЯ
Authors: Вікторія Коваленко  
Published: July 2022

Статтю присвячено проблемам забезпечення фінансової безпеки банків України.
В умовах військової агресії, вітчизняні банки втратили значну частину клієнтської бази, банківські операції спрямовані в більшій мірі на обслуговування грошових потоків. Банки змушені застосовувати пролонгацію погашення кредитної заборгованості, джерела щодо формування власних ресурсів значно скоротилися. Такий канал поповнення ресурсів банків як заощадження домогосподарств, взагалі відсутній через зростання безробіття, зниження доходів, появою додаткових витрат на медичні потреби та на самозахист. В цих умовах надзвичайно актуальною стає тема забезпечення фінансової безпеки банківської діяльності..
Розглянуто найважливіші нормативно-правові документи, які визначають новітні детермінанти для формування стратегії фінансової безпеки банків, а саме: Стратегія економічної безпеки України на період до 2025 року, Стратегія забезпечення державної безпеки, Стратегія розвитку фінансового сектору України до 2025 року, Стратегія розвитку фінтеху в Україні до 2025 року.
В статті визначено загрози, які впливають на рівень фінансової безпеки банківської системи. Їх класифіковано на фактори, що викликають структурні дисбаланси економіки, і ті, що впливають на рівень фінансової безпеки банківської системи. Доведено, що на сьогодні, надзвичайною загрозою виступає військова агресія, яка висуває на перше місце загрозу щодо легалізації злочинних доходів і фінансуванню тероризму.
На підставі використання методики Міністерства економічного розвитку і торгівлі України було визначено рівень фінансової безпеки шляхом розрахунку інтегрального показника. Розрахунок окремих показників, що включені в інтегральний, та їх динаміка свідчать про недостатній рівень здатності банківської системи України протягом 2016–2021 рр. протистояти негативному впливу факторів зовнішнього та внутрішнього середовищ. Порогові значення індикаторів фінансової безпеки банків вказують на негативні явища, такі як: втрата банком ознак системності, здатності до стійкості, динамічного розвитку, конкурентоспроможності на зовнішніх і внутрішніх ринках, що може призвести до визнання стану проблемності та неплатоспроможності.
Резюмуючи статтю можна стверджувати, що необхідне є розробка та впровадження комплексу заходів, спрямованих на підвищення загального рівня фінансової безпеки банківської системи на підставі формування новітньої Комплексної програми забезпечення фінансової безпеки банків України.
A Look at Outbursts of Comet C/2014 UN271 (Bernardinelli–Bernstein) near 20 au
Authors: Kelley Michael S. P. , Kokotanekova Rosita , Holt Carrie E. , Protopapa Silvia , Bodewits Dennis , Knight Matthew M. , Lister Tim , Usher Helen , Chatelain Joseph , Gomez Edward , Greenstreet Sarah , Angel Tony , Wooding Ben 
Published: July 2022

Abstract
Cometary activity may be driven by ices with very low sublimation temperatures, such as carbon monoxide ice, which can sublimate at distances well beyond 20 au. This point is emphasized by the discovery of the Oort cloud comet C/2014 UN271 (Bernardinelli–Bernstein) and its observed activity out to ∼26 au. Through observations of this comet’s optical brightness and behavior, we can potentially discern the drivers of activity in the outer solar system. We present a study of the activity of comet Bernardinelli–Bernstein with broad-band optical photometry taken at 19–20 au from the Sun (2021 June to 2022 February) as part of the LCO Outbursting Objects Key (LOOK) Project. Our analysis shows that the comet’s optical brightness during this period was initially dominated by cometary outbursts, stochastic events that ejected ∼107 to ∼108 kg of material on short (<1 day) timescales. We present evidence for three such outbursts occurring in 2021 June and September. The nominal nuclear volumes excavated by these events are similar to the 10–100 m pit-shaped voids on the surfaces of short-period comet nuclei, as imaged by spacecraft. Two out of three Oort cloud comets observed at large pre-perihelion distances exhibit outburst behavior near 20 au, suggesting such events may be common in this population. In addition, quiescent CO-driven activity may account for the brightness of the comet in 2022 January to February, but that variations in the cometary active area (i.e., the amount of sublimating ice) with heliocentric distance are also possible.
Atmospheric Gravitational Tides of Earth-like Planets Orbiting Low-mass Stars
Authors: Navarro Thomas , Merlis Timothy M. , Cowan Nicolas B. , Gomez Natalya 
Published: July 2022

Abstract
Temperate terrestrial planets orbiting low-mass stars are subject to strong tidal forces. The effects of gravitational tides on the solid planet and that of atmospheric thermal tides have been studied, but the direct impact of gravitational tides on the atmosphere itself has so far been ignored. We first develop a simplified analytic theory of tides acting on the atmosphere of a planet. We then implement gravitational tides into a general circulation model of a static-ocean planet in a short-period orbit around a low-mass star—the results agree with our analytic theory. Because atmospheric tides and solid-body tides share a scaling with the semimajor axis, we show that there is a maximum amplitude of the atmospheric tide that a terrestrial planet can experience while still having a solid surface; Proxima Centauri b is the poster child for a planet that could be geophysically Earth-like but with atmospheric tides more than 500× stronger than Earth’s. In this most extreme scenario, we show that atmospheric tides significantly impact the planet’s meteorology—but not its climate. Two possible modest climate impacts are enhanced longitudinal heat transport and cooling of the lowest atmospheric layers. The strong radiative forcing of such planets dominates over gravitational tides, unlike moons of cold giant planets, such as Titan. We speculate that atmospheric tides could be climatologically important on planets where the altitude of maximal tidal forcing coincides with the altitude of cloud formation and that the effect could be detectable for non-Earth-like planets subject to even greater tides.
Differentially Expressed Inflammation-Regulating MicroRNAs in Oligoarticular Juvenile Idiopathic Arthritis
Authors: McAlpine Sarah M. , Roberts Sarah E. , Hargreaves Breanna K.V. , Bullock Claire , Ramsey Suzanne , Stringer Elizabeth , Lang Bianca , Huber Adam , György Bence , Erdélyi Fruzsina , Issekutz Thomas B. , Dérfalvi Beáta 
Published: July 2022

ObjectiveTo evaluate microRNA expression in synovial fluid (SF), plasma, and leukocytes from patients with juvenile idiopathic arthritis (JIA).MethodsMicroRNA expression in pooled JIA plasma and SF was assessed by absolute quantitative droplet digital PCR array. The results were validated in individual patient samples. MicroRNA content in leukocytes and extracellular vesicles was evaluated by real-time PCR in JIA blood and SF. Blood microRNA expression was compared with healthy controls (HCs). Principal component analysis was used to profile JIA plasma and SF microRNAs, and the potential biological consequences of microRNA dysregulation were investigated by pathway analysis.ResultsMiR-15a-5p and miR-409-3p levels were higher in JIA plasma than in HC plasma. JIA SF contained elevated levels of miR-21-5p, miR-27a-3p, miR-146b-5p, miR-155-5p, and miR-423-5p, and decreased miR-192-5p and miR-451a, compared to JIA plasma. Extracellular vesicle analysis demonstrated variable encapsulation among selected microRNAs, with only miR-155-5p being represented substantially in extracellular vesicles. SF leukocytes also had higher expression of miR-21-5p, miR-27a-3p, miR-146b-5p, and miR-155-5p, and lower expression of miR-409-3p and miR-451a, relative to blood. No differences were observed between JIA and HC blood leukocytes. Clusters of microRNAs were commonly altered in JIA joint fluid and leukocytes compared to JIA blood samples. In silico analysis predicted that differentially expressed microRNAs in JIA target the transforming growth factor (TGF)-β pathway.ConclusionThe expression of multiple microRNAs is dysregulated in JIA both locally and systemically, which may inhibit the TGF-β pathway. These findings advance our knowledge of JIA immunopathogenesis and may lead to the development of targeted therapies.