bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anode/Cathode Dual‐Purpose Aluminum Current Collectors for Aqueous Zinc‐Ion Batteries
Authors: Zhu Ruijie , Xiong Zetao , Yang Huijun , Wang Ning , Kitano Sho , Zhu Chunyu , Aoki Yoshitaka , Habazaki Hiroki 
Published: December 2022

AbstractRechargeable aqueous zinc (Zn)‐ion batteries (RAZIBs), which use non‐flammable aqueous electrolytes and low‐cost electrode materials, show great potential to boost the development of safe, cost‐effective, and highly efficient energy storage systems. The adoption of lightweight and inexpensive aluminum (Al) as current collectors seems to be a good vision, but Al exhibits an easily‐corroded nature and a high impedance in aqueous electrolytes, making it a challenge to realize the utilization of Al current collector in RAZIBs. In this study, through the direct current magnetron sputtering, niobium (Nb) coated Al (Al‐Nb) foils are prepared, which shows superior corrosion‐resistance in an aqueous solution, while maintaining a satisfying electronic conductivity. Moreover, the Al‐Nb foils can be adopted to both anode and cathode current collectors while exhibiting high coulombic efficiency and good cycling stability even when they are tested under a condition that can meet the real‐world application demands, e.g., the Zn||Al‐Nb half‐cell shows an average coulombic efficiency of 99.17% in 320 cycles under a current density of 25 mA cm−2 and a galvanizing capacity of 6.25 mAh cm−2. The superior performance of the modified Al current collectors may mark a significant step toward the development of high‐energy‐density aqueous batteries.
Diselenide‐Based Dual‐Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy
Authors: Wan Shu‐Cheng , Ye Meng‐Jie , Yang Qi‐Chao , Zhang Tian , Zhang Meng‐Jie , Ma Xian‐Bin , Xu Ji‐Ming , Wang Shuo , Wu Zhi‐Zhong , Yang Lei‐Lei , Shen Xue‐Meng , Xu Zhigang , Sun Zhi‐Jun 
Published: December 2022

AbstractPyroptosis is demonstrated to trigger antitumor immunity and represents a promising new strategy to potentiate cancer immunotherapy. The number of potent pyroptosis inducers, however, is limited and without tumor‐targeting capability, which inevitably causes damage in normal tissues. Herein, a small molecular prodrug of paclitaxel‐oxaliplatin is rationally synthesized, which can be covalently self‐assembled with diselenide‐containing cross‐linking (Dse11), producing a diselenide nanoprodrug (DSe@POC) to induce pyroptosis for the first time. The diselenide bonds within DSe@POC can be split by high glutathione in the tumor microenvironment (TME) and reactive oxygen species induced by photodynamic therapy, thus possessing excellent TME on‐target effects. Additionally, DSe@POC is able to elicit intense pyroptosis to remodel the immunostimulated TME and trigger a robust immune response. Furthermore, combined αPD‐1 therapy effectively inhibits the growth of remote tumors through the abscopal effect, amplifies a long‐term immune memory response to reject rechallenged tumors, and prolongs survival. Collectively, DSe@POC, as the first TME dual‐responsive diselenide‐based pyroptosis inducer, will open up an attractive approach for cancer immunotherapy.
Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active‐Transporting of Liposome in Solid Tumor
Authors: Wang Guowei , Jiang Yifan , Xu Junjun , Shen Jiaxin , Lin Tao , Chen Jifan , Fei Weidong , Qin Yating , Zhou Zhuxian , Shen Youqing , Huang Pintong 
Published: December 2022

AbstractLigand/receptor‐mediated targeted drug delivery has been widely recognized as a promising strategy for improving the clinical efficacy of nanomedicines but is attenuated by the binding of plasma protein on the surface of nanoparticles to form a protein corona. Here, it is shown that ultrasonic cavitation can be used to unravel surface plasma coronas on liposomal nanoparticles through ultrasound (US)‐induced liposomal reassembly. To demonstrate the feasibility and effectiveness of the method, transcytosis‐targeting‐peptide‐decorated reconfigurable liposomes (LPGLs) loaded with gemcitabine (GEM) and perfluoropentane (PFP) are developed for cancer‐targeted therapy. In the blood circulation, the targeting peptides are deactivated by the plasma corona and lose their targeting capability. Once they reach tumor blood vessels, US irradiation induces transformation of the LPGLs from nanodrops into microbubbles via liquid–gas phase transition and decorticate the surface corona by reassembly of the lipid membrane. The activated liposomes regain the capability to recognize the receptors on tumor neovascularization, initiate ligand/receptor‐mediated transcytosis, achieve efficient tumor accumulation and penetration, and lead to potent antitumor activity in multiple tumor models of patient‐derived tumor xenografts. This study presents an effective strategy to tackle the fluid biological barriers of the protein corona and develop transcytosis‐targeting liposomes for active tumor transport and efficient cancer therapy.
As Fiber Meets with AIE: Opening a Wonderland for Smart Flexible Materials
Authors: Li Haoxuan , Jin Bingqi , Wang Yuanwei , Deng Bingyao , Wang Dong , Tang Ben Zhong 
Published: December 2022

AbstractAggregation‐induced emission luminogens (AIEgens) have recently been developed at a tremendous pace in the area of organic luminescent materials by virtue of their superior properties. However, the practical applications of AIEgens still face the challenge of transforming AIEgens from molecules into materials. Till now, many AIEgens have been integrated into fiber, endowing the fiber with prominent fluorescence and/or photosensitizing capacities. AIEgens and fiber complement each other for making progress in flexible smart materials, in which the utilization of AIEgens creates new application possibilities for fiber, and the fiber provides an excellent carrier for AIEgens towards realizing the conversion from molecule to materials and an ideal platform to research the aggregate state of AIEgens in mesoscale and macroscale. This review begins with a brief summary of the recent advances related to some typical AIEgens with various functions and the technology for the fabrication of AIEgen‐functionalized fiber. The most representative applications are then highlighted by focusing on energy conversion, personal protective equipment, biomedical, sensor, and fluorescence‐related fields. Finally, the challenges, opportunities, and tendencies in future development are discussed in detail. This review hopes to inspire innovation in AIEgens and fiber from the view of mesoscale and macroscale.
Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway‐Based Approach
Authors: Saarimäki Laura Aliisa , Morikka Jack , Pavel Alisa , Korpilähde Seela , del Giudice Giusy , Federico Antonio , Fratello Michele , Serra Angela , Greco Dario 
Published: December 2022

AbstractMechanistic toxicology provides a powerful approach to inform on the safety of chemicals and the development of safe‐by‐design compounds. Although toxicogenomics supports mechanistic evaluation of chemical exposures, its implementation into the regulatory framework is hindered by uncertainties in the analysis and interpretation of such data. The use of mechanistic evidence through the adverse outcome pathway (AOP) concept is promoted for the development of new approach
methodologies (NAMs) that can reduce animal experimentation. However, to unleash the full potential of AOPs and build confidence into toxicogenomics, robust associations between AOPs and patterns of molecular alteration need to be established. Systematic curation of molecular events to AOPs will create the much‐needed link between toxicogenomics and systemic mechanisms depicted by the AOPs. This, in turn, will introduce novel ways of benefitting from the AOPs, including predictive models and targeted assays, while also reducing the need for multiple testing strategies. Hence, a multi‐step strategy to annotate AOPs is developed, and the resulting associations are applied to successfully highlight relevant adverse outcomes for chemical exposures with strong in vitro and in vivo convergence, supporting chemical grouping and other data‐driven approaches. Finally, a panel of AOP‐derived in vitro biomarkers for pulmonary fibrosis (PF) is identified and experimentally validated.
Optoelectronic Resistive Memory Based on Lead‐Free Cs2AgBiBr6 Double Perovskite for Artificial Self‐Storage Visual Sensors
Authors: Ye Haibo , Liu Zhiyong , Sun Bo , Zhang Xuning , Shi Tielin , Liao Guanglan 
Published: December 2022

AbstractMimicking the human visual memory system has attractive prospects in the field of artificial vision. However, the prominent challenge of realizing human visual memory is how to detect and store image information at the same time, which demands a multifunctional electronic device that can sense and memorize image information like the brain. In this work, simple two‐terminal optoelectronic resistive random access memory (ORRAM) devices are demonstrated based on lead‐free Cs2AgBiBr6 perovskite, exhibiting a unique optoelectronic resistive characteristic that can be reset by UV light illumination. A proof‐of‐concept artificial self‐storage visual system based on the ORRAM is constructed, which shows similar reinforcement learning and memory forgetting functions to the human visual memory system, and realizes the integrated functions of image sensing and memory for a long‐term retention time (>6000 s). Theoretical calculations indicate that UV light illumination will induce the annihilation of Br defects and cause the fracture of conductive filaments, resulting in the optical RESET phenomenon. Furthermore, by integrating with perovskite solar cells, an all‐optically controlled universal implication logic gate is constructed. This work provides an important step toward the mimicry of human visual memory and the multifunctional artificial visual integration of perception and storage.
Magnetic and Electric Field Dependent Charge Transfer in Perovskite/Graphene Field Effect Transistors
Authors: Cottam Nathan D. , Austin Jonathan S. , Zhang Chengxi , Patanè Amalia , Escoffier Walter , Goiran Michel , Pierre Mathieu , Coletti Camilla , Mišeikis Vaidotas , Turyanska Lyudmila , Makarovsky Oleg 
Published: December 2022

AbstractStable all‐inorganic CsPbX3 perovskite nanocrystals (PNCs) with high optical yield can be used in combination with graphene as photon sensors with high responsivity (up to 106 A W−1) in the VIS‐UV range. The performance of these perovskite/graphene field effect transistors (FET) is mediated by charge transfer processes at the perovskite – graphene interface. Here, the effects of high electric (up to 3000 kV cm−1) and magnetic (up to 60 T) fields applied perpendicular to the graphene plane on the charge transfer are reported. The authors demonstrate electric‐ and magnetic‐field dependent charge transfer and a slow (>100 s) charge dynamics. Magneto‐transport experiments in constant (≈0.005 T s−1) and pulsed (≈1000 T s−1) magnetic fields reveal pronounced hysteresis effects in the transfer characteristics of the FET. A magnetic time is used to explain and model differences in device behavior under fast (pulsed) and slowly (continuous) changing magnetic fields. The understanding of the dynamics of the charge transfer in perovskite/graphene heterostructures developed here is relevant for exploitation of these hybrid systems in electronics and optoelectronics, including ultrasensitive photon detectors and FETs for metrology.
Pipeline installation effects on soils and plants: A review and quantitative synthesis
Authors: Brehm Theresa , Culman Steve 
Published: December 2022

AbstractOil and natural gas pipelines are essential to the transport of energy materials, but construction of these pipelines commonly causes disturbance to ecosystems. Due to variability in pipeline installation practices and environments, drawing consensus about how pipeline installations typically impact ecosystems is challenging. Here, we performed a systematic literature review to compile studies that have evaluated impacts of pipeline installation on soil and plant properties. We found 34 studies reporting pipeline impacts on agricultural and natural ecosystems from eight countries. We quantified and synthesized the magnitude of responses and found that the majority of studies found pipeline installation resulted in soil degradation via increased compaction and soil mixing, paired with decreased aggregate stability and soil carbon (C) relative to adjacent, undisturbed areas. Averaged across all studies, aggregate stability decreased 44.8%, water infiltration was reduced 85.6%, and compaction via penetration resistance increased 40.9% over pipeline areas relative to nondisturbed adjacent areas. This soil degradation led to general declines in plant productivity, with 15 out of 25 studies documenting declines in crop yields (6.2–45.6%) and six out of nine studies reporting decreased biomass from natural ecosystems (1.7–56.8%). We conclude from our quantitative synthesis that pipeline installation typically results in degraded soil and vegetation resources, and this can persist for many years following installation.
Growth, yield, and yield stability of canola in the Northern Great Plains of the United States
Authors: Arinaitwe Unius , Clay Sharon A. , Nleya Thandiwe 
Published: December 2022

AbstractCanola (Brassica napus L.) may diversify wheat‐based cropping systems in the Northern Great Plains. However, agronomic adaptability and stability of high‐yielding genotypes have not been widely evaluated over the diverse environmental conditions of South Dakota (SD). A 2‐year field experiment was conducted in two contrasting environments (Brookings—eastern SD and Pierre—Central SD) to evaluate genotypes (10 in 2019 and 12 in 2020) for days to 50% flower, lodging, pods plant−1, seed yield, 1000‐seed weight, and yield stability. Seed yield for all genotypes in Brookings averaged 1961 and 1740 kg ha−1, in 2019 and 2020, respectively, whereas at Pierre, yields averaged 1470 and 858 kg ha−1. Seed oil concentration was greater at Brookings (456 and 406 g kg−1 in 2019 and 2020, respectively) than at Pierre (356 g kg−1 in 2019). The additive main effects and multiplicative interaction model (AMMI) evaluated eight genotypes across locations and years for genotype × environment (GE) interactions and stability. Environment was the most dominant cause of variation among genotypes, explaining 67.7%, 41.4%, and 45.7%, of the variations in pods plant−1, 1000‐seed weight, and seed yield, respectively, whereas GE explained most of the remaining variation. A combination of AMMI‐1 biplots and AMMI stability values found variability in genotypic response to environments for seed yield suggesting cultivar recommendations should be environment specific.
Visualization of supramolecular assembly by aggregation‐induced emission
Authors: Guo Wu‐Jie , Peng Tuokai , Zhu Wenping , Ma Shixiang , Wang Guang , Li Ying , Liu Bin , Peng Hui‐Qing 
Published: December 2022

AbstractSupramolecular architectures are constructed by the self‐assembly of small building blocks via the use of metal‐ligand coordination, π–π stacking interactions, hydrogen bonding, host‐guest interactions, and other noncovalent driving forces, which confer unique dynamic reversibility and stimulus responsiveness to the supramolecular materials and also lead to the demand of expensive and complex equipment for the characterization of supramolecular assembly processes. Fortunately, the self‐assembly processes bring the monomeric chromophores together, offering possibilities to establish ties between the supramolecular assembly and aggregation‐induced emission (AIE) techniques. Compared to conventional luminescent molecules, AIE luminogens (AIEgens) exhibit significant fluorescence enhancement upon the restriction of molecular motions, thus displaying the advantages of signal amplification and low background noises. Given the above, the real‐time, sensitive, and in situ visualization of the formation of self‐assemblies and their stimuli responsiveness based on AIE becomes accessible. Here, we review recent works that encompass the visualization of supramolecular assembly‐related behaviors by means of AIE characteristics of chromophores. The organization of this review will be by different types of supramolecular architectures, including metallacycles/cages, micelles/vesicles, supramolecular polymers, and supramolecular gels. An overview of future opportunities and challenges for the real‐time monitoring of supramolecular assembly by AIE is also provided.
The impact of COVID‐19 on the number of births in Yucatan, Mexico
Authors: Azcorra Hugo , Salazar‐Rendón Juan Carlos , Rodríguez Luis , Vázquez‐Vázquez Adriana , Mendez‐Dominguez Nina 
Published: December 2022

AbstractObjectiveTo analyze the impact of COVID‐19 on the number of births in Yucatan, Mexico during 2020 and 2021.Material and MethodsA total of 470 651 live births occurred in Yucatan from January 1st, 2008, to December 31st, 2021, and were included in the analysis. The monthly number of births observed during January 2008–February 2020 was used to describe pre‐pandemic trends. Time‐series analysis was applied to examine whether the number of births observed from December 2020 (9 months after the beginning of the pandemic) to December 2021 differed from the expected values. Trends in the number of births according to maternal age, parity and education were examined to identify changes differentiated by sociodemographic characteristics.ResultsThe number of births in 2021 decreased by 18% (5869 births) compared with 2019, which represents a reduction from 12.89 to 12.48 per thousand inhabitants. The observed number of births from December 2020 to July 2021 was significantly lower than the figure expected. April (expected = 2863 vs. observed = 1722), May (expected = 2948 vs. observed = 1990), and June (expected = 2997 vs. observed = 1978) 2021 showed the largest differences between expected and observed values. Then, from August to December 2021, the observed number of births fell within the expected range. Birth decline was slightly more pronounced among mothers between 20 and 29 years of age and in those without previous offspring.ConclusionWe provide evidence of birth decline in Yucatan during the COVID‐19 pandemic. Birth rate reduction in Yucatan doubled the world average and young women without children were the most affected.
The ancient inhabitants of the Chonos Archipelago (~43°–47°S): Characterization of maritime hunter‐gatherers from Western Patagonia using mitochondrial DNA
Authors: Moraga Mauricio , de la Fuente Constanza , Galimany Jacqueline , Orellana‐Soto Michael , Reyes Omar 
Published: December 2022

AbstractBackgroundWithin the southern end of South America, Western Patagonia arises as an intricate region of channels, fjords, and islands. This region holds evidence of human occupation since ca. 14,500 cal years BP, with distinctive maritime adaptations developing around 7300 cal years BP. Historically, three major populations were characterized as part of these maritime traditions: Yámana, Kawésqar, and Chono. The arrival of European population had a profound impact in these communities, affecting their lifestyles, territory and population size and health. The northernmost populations, living within the Chonos Archipelago, were the most affected and the least known communities from Western Patagonia.ObjectivesThis research aims to characterize the mitochondrial DNA diversity of ancient individuals from the Chonos Archipelago, evaluating their genetic affinities with other ancient and present‐day populations from Patagonia.Materials and MethodsA total of 46 individuals from the region were sampled for ancient DNA analysis. Mitochondrial DNA haplogroups were characterized and compared with ancient and present‐day populations from Southern South America.ResultsAll individuals from the Chonos Archipelago belong to C and D haplogroups, particularly to C1b, C1b13, D1, D1g, and D4h3a5. As a group, the individuals from Chonos Archipelago lay closer to ancient individuals from Kawésqar territory, immediately south of them. Using mitogenomes, we characterized two new D4h3a5 lineages almost exclusively associated with populations from Western Patagonia.DiscussionOur results contribute to the understanding of the peopling and human interactions in Western Patagonia, suggesting these unique maritime traditions developed within local populations, genetically associated with earlier terrestrial populations.
A Telomerase‐Assisted Strategy for Regeneration of DNA Nanomachines in Living Cells
Authors: Zhang Qianying , Wang Yihan , Wang Wenjing , Min Qianhao , Zhang Jian‐Rong , Zhu Jun‐Jie 
Published: December 2022

AbstractDNA nanomachines have been engineered into diverse personalized devices for diagnostic imaging of biomarkers; however, the regeneration of DNA nanomachines in living cells remains challenging. Here, we report an ingenious DNA nanomachine that can implement telomerase (TE)‐activated regeneration in living cells. Upon apurinic/apyrimidinic endonuclease 1 (APE1)‐responsive initiation of the nanomachine, the walker of the nanomachine moves along tracks regenerated by TE, generating multiply amplified signals through which APE1 can be imaged in situ. Additionally, augmentation of the signal due to the regeneration of the nanomachines could reveal differential expression of TE in different cell lines. To the best of our knowledge, this is the first proof‐of‐concept demonstration of the use of biomarkers to assist in the regeneration of nanomachines in living cells. This study offers a new paradigm for the development of more applicable and efficient DNA nanomachines.
Ru3(CO)12‐Catalyzed Modular Assembly of Hemilabile Ligands by C−H Activation of Phosphines with Isocyanates
Authors: Lin Lin , Zhang Xue‐jun , Xu Xinyu , Zhao Yue , Shi Zhuangzhi 
Published: December 2022

AbstractHemilabile ligands have been applied extensively in transition metal catalysis, but preparations of these molecules typically require multistep synthesis. Here, modular assembly of diverse phosphine‐amide ligands, including related axially chiral compounds, is first reported through ruthenium‐catalyzed C−H activation of phosphines with isocyanate directed by phosphorus(III) atoms. High reactivity and regioselectivity can be obtained by using a Ru3(CO)12catalyst with a mono‐N‐protected amino acid ligand. This transformation significantly expands the pool of phosphine‐amide ligands, some of which have shown excellent efficiency for asymmetric catalysis. More broadly, the discovery constitutes a proof of principle for facile construction of hemilabile ligands directly from the parent monodentate phosphines by C−H activation with ideal atom, step and redox economy. Several dinuclear ruthenium complexes were characterized by single‐crystal X‐ray diffraction analysis revealing the key mechanistic features of this transformation.