bluuebunny/crossref_metadata_2025_split huggingface dataset:
Évaluation de supports de communication nationaux sur la COVID-19 : recours à une méthode mixte
Authors: Pasquereau Anne , Delamaire Corinne , Guignard Romain , Bonmarin Isabelle , Serry Anne-Juliette , Nguyen-Thanh Viêt 
Published: March 2022

Introduction : Les enjeux de communication auprès du grand public, lors d’une crise sanitaire, sont multiples, avec pour objectif in fine une application des gestes de prévention par le plus grand nombre. Objectif : L’objectif de cet article est de présenter les résultats d’une évaluation des outils de communication sur la COVID-19 déployés par Santé publique France, pour le grand public, en mars 2020. Deux études, une quantitative et une qualitative, ont été menées au cours du premier confinement. Le dispositif de communication « Alerte Coronavirus » comprenait alors quatre supports (spots et affiches) décrivant les gestes barrières et les signes de la maladie. Résultats : La mémorisation de la campagne était particulièrement élevée : neuf personnes sur dix citant spontanément des messages de cette campagne. Plus de 90 % l’ont trouvée facile à comprendre ou utile, même si 20 % l’ont jugée anxiogène. L’impact déclaré sur les comportements s’est aussi révélé très élevé, 97 % des personnes affirmant être incitées à appliquer les gestes barrières. Une moindre adhésion à la campagne a, toutefois, été observée parmi les hommes et les catégories modestes. L’étude qualitative a permis d’expliciter certains des résultats : la clarté des supports a été attribuée aux pictogrammes illustrant les gestes barrières, et le ton des spots a été jugé adapté à la gravité de la situation sanitaire. Conclusion : Ces études mettent en évidence une exposition élevée aux supports testés et une perception positive de ceux-ci. Leurs enseignements ont été utiles pour poursuivre la diffusion des outils de prévention produits par Santé publique France.
Un modèle innovant d’intervention, de dépistage et de prise en charge mobile de la COVID-19 chez les personnes sans-abri à Marseille
Authors: Mosnier Émilie , Farnarier Cyril , Mosnier Marine , Allaria Camille , Loubière Sandrine , Monfardini Elisabetta , Rebaudet Stanislas , Bosetti Thomas , Tinland Aurélie 
Published: March 2022

Introduction : Les personnes en situation de sans-abrisme sont plus à risque de contracter l’infection à SARS-CoV-2, du fait notamment de leurs conditions de vie précaires qui rendent difficile le maintien des mesures barrières. Un projet de recherche portant sur la COVID parmi les personnes sans-abri (cohorte COVIDhomeless) a mis en évidence des discontinuités de recours aux soins chez les personnes incluses. Objectif : Nous décrivons une intervention innovante, issue du projet de recherche cohorte COVIDhomeless, dont l’objectif était de proposer une action mobile de dépistage COVID-19 et de suivi adaptée aux besoins des personnes en situation de sans-abrisme (rue, squat, bidonville ou hébergement d’urgence) à Marseille. Résultats : L’intervention comprenait 1) la coordination de 18 structures institutionnelles et associatives en lien avec ces publics, 2) la formation et la mise à disposition de tests rapides de diagnostic sérologique et antigénique auprès des acteurs de terrain, 3) la mise en place d’une équipe mobile dédiée organisant le dépistage, accompagnée par des médiateurs communautaires formés à la médiation en santé, le diagnostic rapide par test virologique PCR en « point of care », le conseil et le suivi, ainsi qu’un accompagnement adapté aux personnes positives à la COVID-19. L’acceptabilité de l’intervention a été bonne tant du point de vue des structures que des acteurs de terrain et des bénéficiaires. Le manque de disponibilité d’hébergements adaptés a été retrouvé comme un facteur central dans la limitation des prises en charge. Conclusion : Des équipes mobiles dédiées, sur le principe de « l’aller-vers », semblent limiter l’impact de l’épidémie dans cette population à risque.
Impact de la pandémie COVID-19 sur les évènements indésirables associés aux soins
Authors: Morgand Claire , Cabarrot Philippe , Coniel Marie , Prunet Caroline , Gloanec Marie , Morin Sandrine , Grenier Catherine 
Published: March 2022

Depuis début 2020, début de la pandémie COVID-19, les médecins ont continué à déclarer des évènements indésirables associés aux soins (EIAS). Les patients ont également continué à participer aux enquêtes de satisfaction relatives à leur hospitalisation. À ce jour, aucune étude en France n’a mesuré les conséquences de la pandémie sur les EIAS et la satisfaction du patient. Nous avons étudié les caractéristiques des EIAS en lien avec la pandémie et mis en perspectives le ressenti des patients. Une étude qualitative et observationnelle rétrospective de la base REX et de la base e-satis MCO48 ont été conduites. L’étude quantitative de la base REX a été complétée par une analyse qualitative des déclarations. Les EIAS concernent plus souvent des hommes d’âge moyen 60 ans, les décès survenus intéressent des patients plus âgés, avec des pathologies plus complexes et dont la prise en charge est plus urgente. La nature des EIAS est différente en fonction de la période de déclaration : ceux déclarés lors de la première vague sont plus urgents, surviennent moins souvent au bloc opératoire qu’aux urgences et sont jugés moins évitables que ceux survenus lors de la deuxième période. Ces derniers se rapprochent plus des EIAS survenant habituellement. La mise en place de barrières efficaces, notamment au sein des équipes, a permis de réduire l’impact de la deuxième vague sur la survenue de ces évènements, le rôle de la communication apparaît essentiel. Le score global de satisfaction des patients et ceux relatifs aux prises en charge médicales et paramédicales ont augmenté, ce résultat pouvant être le reflet de la solidarité des patients envers les soignants. L’attitude de résilience active de la part de tous les acteurs a été un élément majeur dans la gestion des risques lors de cette crise, et il est essentiel de capitaliser sur ces processus collaboratifs pour l’avenir.
Unravelling the identity of pest thrips (Thysanoptera: Thripidae) of bananas (Musaceae) in Brazil
Authors: Sutil Weidson Plauter , Barbosa Regilene Bento , Santos Rodrigo Souza , Fancelli Marilene , Lima Élison Fabrício Bezerra 
Published: March 2022

AbstractA total of eight species of thrips (Thysanoptera: Thripidae) have been listed as banana pests in Brazil. Their feeding and oviposition behaviour on these fruits damage their appearance in ways that can impair commercial value. As a result, taxonomic studies that seek to correctly identify thrips can positively impact the cultivation of bananas. Many earlier records of banana thrips in Brazil consist of doubtful identifications or untraceable reports. In this paper, the identification of these banana pests in Brazil is revised and an illustrated identification key is provided. The specimens examined were collected over a period of 10 years from the most representative banana-growing areas in Brazil. Seven banana thrips in Brazil are now recognised:Bradinothrips musae(Hood),Chaetanaphothrips orchidii(Moulton),Danothrips trifasciatusSakimura,Elixothrips brevisetis(Bagnall),Frankliniella brevicaulisHood,Frankliniella parvulaHood, andHoodothrips lineatus(Hood).Chaetanaphothrips orchidiiandDanothrips trifasciatusare recorded for the first time as causing damage to banana crops in Brazil. In addition, the following three species are considered misidentifications and should be disregarded as banana pests in Brazil:Frankliniella fulvipennisMoulton,Hercinothrips bicinctus(Bagnall), andHercinothrips femoralis(Reuter).
The prevalence of thyroid nodules and risk factors of thyroid nodules with metabolic disorder in Beijing
Authors: Zhang Yuanyuan , Wehbe Alexandra , Wang Xuhong , Sun Rong Xin , Zheng Zhao Hui , Zhao Dong 
Published: March 2022

Background:
In recent years, the prevalence of thyroid nodules (TNs) has been increasing, but the relationship between metabolic abnormalities and the incidence of TNs is not well defined, and there is scant data evaluating this relationship stratified by gender. This study aims to analyze the prevalence of TNs and possible risk factors for TNs across gender lines and various metabolic states in Beijing, China.

Patients and Methods:
A total of 6001 subjects who underwent thyroid ultrasounds as part of a routine medical checkup at Luhe Hospital between 2017 and 2018 were enrolled in this study. Multivariate adjustment logic was used to analyze possible demographic and clinical risk factors of TN stratified by gender.

Results:
The prevalence of TNs was 44.1%, of which 45.9% were female and 40% were male. In general, the prevalence of TNs increased in parallel with advancing age. These findings were even starker among females, with TN prevalences of 37.5%, 46.5%, 52.9%, and 54.1%, among participants in <55-, 55–65-, 65–75-, and >75-year-old age groups, respectively. The prevalence of TNs was significantly higher among patients with obesity (46.8% vs. 43%, P = 0.008), central obesity (45% vs. 40.4%, P = 0.005), hypertension (47.1% vs. 42.4%, P < 0.001), metabolic syndrome (MetS) (46.1% vs. 41%, P < 0.001), and low TSH levels (46.5% vs. 37.1%, P < 0.001). MetS and obesity were independent risk factors for the prevalence of TNs (odds ratio [OR] = 1.167, [1.002–1.277] and (OR = 0.038, [1.01–1.396]), respectively). TSH had a protective effect on the prevalence of TNs (OR = 0.664, [0.585–0.75]).

Conclusions:
The present study supports the existing research that contends a strong correlation between older age, MetS, and other clinical risk factors and the prevalence of TNs. This relationship only persisted among women when stratified by gender. These results set the precedent for further research on how gender influences the incidence of TNs, particularly in the setting of other clinical and demographic risk factors.
The retinal vascular growth rate in babies with retinopathy of prematurity could indicate treatment need
Authors: Padhi Tapas Ranjan , Bhusal Utpal , Padhy Srikanta Kumar , Patel Anamika , Kelgaonker Anup , Khalsa Ashish , Das Taraprasad , Kapil Vidushi , Shah Miloni , Sugumar Shalini , Samantaray Balakrushna , Devi Sabita , Ali Mohammad Hasnat , Jalali Subhadra 
Published: March 2022

Purpose:
To analyze the weekly rate of retinal vascular growth in treatment-naïve babies with various stages of retinopathy of prematurity (ROP) and validate if this could be a predictor of treatment need.

Methods:
Retrospective review of medical charts and retinal images of babies with various stages of ROP. The images were enhanced using red-green image enhancement software. Using the length of the horizontal disc diameter (DD) of each eye, the vessel growth was measured from the disc margin up to the vessel tip in fixed quadrants. The rate of vessel growth was the ratio of vessel length to the number of weeks it took to reach this length. The babies were divided into treatment warranting ROP (group 1), low-risk pre-threshold (type II) ROP (group 2,), and no-ROP (group 3) for analysis. The “no-ROP” group acted as normal control. Group 1 was further subdivided into 1A (threshold ROP), IB (aggressive posterior ROP), 1C (hybrid ROP), and ID (high-risk pre-threshold ROP).

Results:
Out of 436 eyes, groups 1, 2, and 3 had 238, 108, and 90 eyes, respectively. The mean rate of vascular outgrowth along with 95% confidence interval (CI) was 0.490 [0.487,0.520], 0.612 [0.599, 0.638], and 0.719 [0.703, 0.740] DD/week, respectively, for babies with “treatment warranting,” “low risk pre-threshold” and “no ROP” groups, respectively. In our estimate, more than 80% of eyes with a vessel growth rate of 0.54 DD/week or less required treatment

Conclusion:
A rate of retinal vascular growth less than 0.54 DD/week can be used to determine treatment requirements in babies with ROP.
Comparison of uveal parameters between acute primary angle-closure eyes and fellow eyes in South Indian population
Authors: Senthilkumar Vijayalakshmi A , Pradhan Chinmayee , Rajendrababu Sharmila , Krishnadas R , Mani Iswarya 
Published: March 2022

Purpose:
To analyze the ocular biometric parameters of eyes with acute primary angle closure (APAC) as compared to fellow eyes.

Methods:
A cross-sectional study was conducted on 27 patients presenting with recent onset APAC to a tertiary eye institute in India. Anterior and posterior ocular biometric parameters were measured simultaneously by anterior segment optical coherence tomography (AS-OCT), A-scan, ultrasound biomicroscopy (UBM), and B-mode ultrasonogram (USG). The parameters measured were anterior chamber depth (ACD), anterior chamber angle (ACA), angle opening distance (AOD500, AOD750), lens vault (LV), axial length (AL), ciliary body thickness maximum (CBTmax) and at the point of scleral spur (CBT0), anterior placement of the ciliary body (APCB), and retinochoroidal thickness (RCS).

Results:
Mean age ± SD of patients with APAC was 55.66 ± 7.2 years with female preponderance (21:6 patients). Mean presenting IOP ± SD of the affected eye and fellow eye were 54.74 ± 11.67 mm Hg and 18.7 ± 11.67 mm Hg, respectively. Eyes with APAC had statistically significant narrower anterior ocular biometric parameters, higher LV, decreased ciliary body thickness, more APCB, and longer AL than the fellow eyes. CBTmax is the only variable that had significance (b = −0.421,95% CI: −0.806 to − 0.035, P = 0.034) in the univariate analysis with RCS thickness in APAC eyes. Further, there was a correlation between CBT0 and APCB with CBTmax both in univariate (b = 0.894, P < 0.0001 and b = −0.351, P = 0.039) and multivariable analysis (b = 0.911, P < 0.0001 and b = −0.416, P = 0.016)

Conclusion:
Compared to the fellow eyes, APAC eyes had different ocular biometric parameters. In addition to known biometric parameters associated with pupillary block (narrower anterior biometric parameters-ACA, ACD, and AOD), our study found multiple nonpupillary block factors such as higher lens vault and thinner and more anteriorly placed ciliary body to be associated with APAC.
Tribal Odisha Eye Disease Study # 11 - Particularly vulnerable tribal group eye health program. Program protocol and validation
Authors: Padhy Debananda , Majhi Debasmita , Marmamula Srinivas , Mishro Ramanandan , Rath Suryasnata , Ota Akhil B , Jalan Manav , Das Taraprasad , Rout Prachi P 
Published: March 2022

Purpose:
To describe and validate the eye health program protocol of Dongria tribal community, a particularly vulnerable tribal group (PVTG) in Rayagada district, Odisha, India.

Methods:
The program would consist of three segments. At people’s residences, trained community health workers (CHWs) will measure the vision and collect demographic data. In addition, vision technicians (VTs) will refract using a hand-held device and prescribe spectacles to people who improve to >6/12, N8. Others would be referred to the vision center (VC). At VC, the VT will perform a slit-lamp examination and re-refract. They would refer people with vision ≤6/12 to the secondary center (SC). At SC, referred people will receive a comprehensive eye examination and treatment. The ophthalmologist will assign the cause of blindness and visual impairment for people with visual acuity <6/12. The entire process was rehearsed in a pilot study.

Results:
The target population is approximately 10,000 people residing in 101 hutments on the hills of Rayagada district. The pilot study included 126 people. The mean age was 44 ± 18 years; 70% of the people were illiterate, and in this cohort, 97.6% (n = 123) had never worn spectacles. In the pilot study, 41% of the people had cataract, and 12% had pterygium. The agreements between optometrist versus VTs and between optometrist versus CHWs were good (k = ~0.8–1.0) in all eye conditions except for strabismus (k = ~0.56–0.65)

Conclusion:
The pilot study confirms the program modality, and when completed, it would help in the planning and resource allocation of Odisha PVTG eye care.
Corneal and corneal epithelial thickness distribution characteristics in healthy North Indian eyes using spectral domain optical coherence tomography
Authors: Malhotra Chintan , Gupta Barkha , Dhiman Rajneesh , Jain Arun K , Gupta Amit , Ram Jagat 
Published: March 2022

Purpose:
To determine the pattern of corneal thickness and epithelial thickness distribution in healthy North Indian eyes by using spectral domain optical coherence tomography (SD-OCT).

Methods:
The observational study measured total corneal and epithelial thickness in the central 2 mm zone and eight sectors each in paracentral 2–5 mm (ring 1) and midperipheral 5–7 mm (ring 2) zones on SD-OCT.

Results:
The study included 67 eyes of 67 subjects with a male:female ratio of 32:35 and mean age of 25.04 ± 4.54 years. The mean central corneal and epithelial thicknesses were 505.97 ± 30.12 mm and 60.48 ± 8.37 mm, respectively. The epithelium of inferior and infero-nasal sectors in ring 1 and inferior sector in ring 2 was significantly thicker than the radially opposite sectors of the respective rings (P = 0.001; P = 0.01 and P = 0.02, respectively). Sector-wise analysis did not reveal any significant correlation between the total corneal thickness and epithelial thickness (all P > 0.05) except in the outer superior sector where there was a weak positive correlation (r = 0.28, P = 0.02). Central epithelial thickness in males (60.59 ± 9.28 mm) and females (60.37 ± 7.58 mm) was comparable (P = 0.91). Pachymetry was thinnest in the inferior, inferonasal, and inferotemporal sectors in 44.79% of eyes (n = 30), while thinnest epithelium was seen in the superior, superonasal, and superotemporal quadrants in 50.75% of eyes (n = 34)

Conclusion:
The epithelial thickness distribution in this sample of topographically normal healthy North Indian eyes was nonuniform and independent of the underlying corneal thickness. Epithelium was thinner in the superior cornea, whereas total corneal thickness was minimum in the inferior part.
Reticular epithelial corneal edema as a novel side-effect of Rho Kinase Inhibitors: An Indian scenario
Authors: Bhargava Mona , Sen Surajit , Bhambhani Varsha , Paul Raj Shekhar , Dutta Chandana 
Published: March 2022

Purpose:
To describe clinical course, characteristics, and outcome of reticular epithelial corneal edema (RECE) occurring as a not-so-infrequent adverse effect of a novel drug, Rho-kinase inhibitors (ROCK-I)- netarsudil (0.02%) and ripasudil (0.4%).

Methods:
This was a retrospective observational non-randomized study. In this study, 12 eyes of 11 patients presenting at a tertiary eye care center between April 2021 and September 2021 were included. All 12 eyes developed a distinctive honeycomb pattern of RECE after starting topical ROCK-I. All patients were subjected to detailed ophthalmic examinations.

Results:
Eight patients were started on netarsudil (0.02%) and three on ripasudil (0.4%). Five eyes had a prior history of corneal edema. The remaining seven had the presence of ocular comorbidities predisposing to corneal edema. The average time for RECE occurrence was 25 days for netarsudil and 82 days for ripasudil. Visual acuity decreased in two eyes, remained unaffected in four eyes, and could not be quantified in four eyes due to preexisting profound visual impairment. Five eyes had symptoms of ocular surface discomfort associated with bullae. Symptoms and bullae resolved in all eyes in whom ROCK-I was stopped. The average time to resolution of RECE was 10 days for netarsudil and 25 days for ripasudil

Conclusion:
RECE after ROCK-I occurs with the use of both netarsudil and ripasudil, although the characteristics differ. The presence of corneal edema and endothelial decompensation seem to be a risk factor, and cautious use is warranted in these patients. Four clinical stages of RECE are described. ROCK-I act as a double-edged sword in patients with endothelial decompensation. Large-scale studies are required to know the exact incidence, pathophysiology, and long-term consequences of the aforementioned side-effect.
Histone deacetylase inhibitor sodium butyrate regulates the activation of toll-like receptor 4/interferon regulatory factor-3 signaling pathways in prostate cancer cells
Authors: Ozkan Asuman Deveci , Eskiler Gamze Guney , Kazan Nur , Turna Ozge 
Published: March 2022

ABSTRACT

Context:
The covalent acetylation and deacetylation of histone proteins by the histone deacetylase (HDAC) enzymes can be considered a novel therapeutic target in prostate cancer (PCa) cells. Sodium butyrate (NaBu) is a HDAC inhibitor (HDACi) which is a promising potential anticancer drug. Toll-like receptor 4 (TLR4) expression is increased in PCa cells and HDACi alter TLR-inducible gene expressions.

Aims:
We aimed to evaluate the effects of NaBu on TLR4 mediating signaling pathways in two different PCa cells (DU-145 and LNCaP) for the first time.

Subjects and Methods:
The cytotoxic and apoptotic effects of NaBu were determined by the water-soluble tetrazolium salt (WST-1) and Annexin V-AO/PI assays, respectively. Subcellular localization of TLR4, interferon regulatory factor-3 (IRF3) and Nuclear factor kappa B proteins was evaluated by IF assay.

Statistical Analysis Used:
All data were statistically analyzed by GraphPad Prism software (V60.1, CA). Obtained data were expressed in a mean ± standard deviation of the three repeated experiments. The differences between control and NaBu treated cells were compared by one-way-ANOVA. P < 0.05 value was considered statistically significant.

Results:
Our results showed that NaBu significantly inhibited the viability of PCa cells and increased the percentage of apoptotic cells. However, DU-145 cells were more sensitive to NaBu than LNCaP cells. Furthermore, NaBu can induce the cytoplasmic TLR4 and IRF3 expression in particularly DU-145 cells without affecting nuclear translocation of NF-kB in PCa cells.

Conclusions:
NaBu induces apoptotic cell death and regulated the TLR4/IRF3 signaling pathways in DU-145 cells but not in LNCaP cells. Therefore, PCa cells differentially responded to NaBu treatment due to probably androgen receptor status.
Rapid and efficient determination of zinc in water samples by graphite furnace atomic absorption spectrometry after homogeneous liquid-liquid microextraction via flotation assistance
Authors: Rezaee Mohammad , Tajer-Mohammad-Ghazvini Parisa 
Published: March 2022

ABSTRACT. A new application of homogeneous liquid–liquid microextraction via flotation assistance (HLLME-FA) has been developed for the determination of Zn(II) in the water samples by using graphite furnace atomic absorption spectrometry (GFAAS). 1-(2-Pyridylazo)-2-naphthol (PAN) was used as a chelating reagent. In this work, low density organic solvent was used as an extraction solvent and no centrifugation was required in this method. A special extraction cell was designed to facilitate collection of the low density extraction solvent. The predominant parameters influencing the HLLME-FA procedure, such as solution pH, concentration of PAN, extraction and homogeneous solvent types and volumes, ionic strength, and extraction time have been optimized. Applying all the optimum conditions in the process, the detection limit of 0.1 μg/L, linear range of 0.5–200 μg/L, and the precision (RSD%, n = 10) of 5.7% were obtained for zinc. The proposed procedure showed satisfactory results for the analysis of tap water, well water and sea water.

KEY WORDS: Homogeneous liquid-liquid microextraction, Flotation assistance, Zinc, Graphite furnace atomic absorption spectrometry, Water samples
Bull. Chem. Soc. Ethiop. 2022, 36(1), 1-11.
DOI: https://dx.doi.org/10.4314/bcse.v36i1.1