bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxygen and carbon isotope variations in Chamelea gallina shells: Environmental influences and vital effects
Authors: Mancuso Arianna , Yam Ruth , Prada Fiorella , Stagioni Marco , Goffredo Stefano , Shemesh Aldo 
Published: September 2022

AbstractStable isotopes in mollusc shells, together with variable growth rates and other geochemical properties, can register different environmental clues, including seawater temperature, salinity and primary productivity. However, the strict biological control over the construction of biominerals exerted by many calcifying organisms can constrain the use of these organisms for paleoenvironmental reconstructions. Biologically controlled calcification is responsible for the so called vital effects that cause a departure from isotopic equilibrium during shell formation, resulting in lower shell oxygen and carbon compared to the equilibrium value. We investigated shell oxygen and carbon isotopic composition of the bivalve Chamelea gallina in six sites along with a latitudinal gradient on the Adriatic Sea (NE Mediterranean Sea). Seawater δ18O and δ13CDIC varied from North to South, reflecting variations in seawater temperature, salinity, and chlorophyll concentration among sites. Shell δ18O and δ13C differed among sites and exhibited a wide range of values along with the ~400 km latitudinal gradient, away from isotopic equilibrium for both isotopes. These results hampered the utilization of this bivalve as a proxy for environmental reconstructions, in spite of C. gallina showing promise as a warm temperature proxy. Rigorous calibration studies with a precise insight of environment and shell growth are crucial prior to considering this bivalve as a reliable paleoclimatic archive.
Effect of tree species on the elemental composition of wood ashes and their fertilizer values on agricultural soils
Authors: Asare Michael O. , Hejcman Michal 
Published: September 2022

AbstractWood ashes obtained from household heating and cooking are often applied to home gardens and arable fields by farmers. The effect of tree species and their locations on the elemental composition of wood ashes derived from domestic cooking and heating is unknown. The study aimed to discover the fertilizer values of wood ashes obtained from Betula pendula, Carpinus betulus, Fagus sylvatica, Larix decidua, Picea abies, Pinus sylvestris, Quercus robur, and Tilia cordata from two different localities, Hlinsko and Mšec, Czech Republic. The total element content in the ashes of dry wood samples (wood and bark) burnt at 460°C with a wood stove interfaced with a thermometer was determined using portable x‐ray spectrometry. The content (in g kg−1) of P (3.23–20.53), K (26.79–136.22), Ca (94.89–295.56), and S (2.97–11.75) in the ashes varies according to the tree species, locality, parent rock, and anthropogenic activities in the location of trees. Additionally, trace element contents ranged from 0.63–32.07 g Mn kg−1, 0.34–4.6 g Fe kg−1, 32.4–2062 mg Zn kg−1, 47.61–193.09 mg Cu kg−1, 3.99–21.53 mg Mo kg−1, and 1.50–6.62 mg Se kg−1. The pH of the ashes ranged from 8.71 to 11.54, suitable to alleviate soil acidity and a condition satisfying soil additive. A significant positive correlation between the contents of Cu, Sr, and Pb with the ashes of Picea abies, Larix decidua, Pinus sylvestris, and Betula pendula at Hlinsko is indicative of ancient anthropogenic activities input in the soil. The combustion of wood under home heating temperatures resulted in the concentration of most risk metal(loid)s, below permissible limits in agricultural soils. Application of wood ashes on arable fields requires considerable caution due to potentially toxic elements (Zn and Pb).
Patient co‐design of digital health storytelling tools for multimorbidity: A phenomenological study
Authors: Cummings Marissa , Bradley Jay , Teal Gemma 
Published: September 2022

AbstractBackgroundInterest in both narrative medicine and electronic health records has increased over the past 30 years. However, electronic health records are mainly written by and for clinicians, and the patient narrative and voice are not incorporated. Recent studies within the United Kingdom have indicated that there is a need to incorporate patient stories into health records, to improve quality and continuity of care. This is particularly important when treating people with multiple long‐term health conditions (multimorbidity), whose health stories can be particularly complex.ObjectiveTo understand the goals and requirements of people with multimorbidity for digital health storytelling tools.MethodsThe methodology uses narrative within a phenomenological approach to inform a process of co‐design.ResultsThe findings indicate that people living with multimorbidity would use health storytelling tools to understand and reflect on their journeys, convey their experiences to others and advocate for themselves against scepticism.ConclusionOutputs from the project give insight into the lived experience of multimorbidity, as well as understanding the goals of people living with multimorbidity for using health storytelling tools as part of treatment and self‐management. Future research could explore other areas such as collaborative health storytelling or the technical implementation of tools.Patient or Public ContributionFive adults with multiple long‐term conditions participated in the project, and research was carried out in three stages. First, semistructured interviews were used to understand each participant's health story. Second, each participant worked with the researcher to co‐design a visual representation of their story. Finally, digital prototypes based on their health story were reviewed with each of the participants.
Tumour necrosis factor plays a deleterious role in the pathogenesis of chikungunya virus infection
Authors: Moreira Thaiane Pinto , Sousa Carla Daiane Ferreira de , Melo Costa Victor Rodrigues de , Queiroz‐Junior Celso Martins , Santos Franciele Martins , Bonilha Caio Santos , Ésper Lísia Maria , Nogueira Mauricio Lacerda , Cunha Thiago Mattar , Teixeira Mauro Martins , Costa Vivian Vasconcelos , de Souza Daniele da Glória 
Published: September 2022

AbstractArthralgia is a hallmark of chikungunya virus (CHIKV) infection and can be very debilitating and associated with a robust local inflammatory response. Many pathophysiological aspects associated with the disease remain to be elucidated. Here, we describe a novel model of CHIKV infection in immunocompetent mice and evaluate the role of tumour necrosis factor in the pathogenesis of the disease. C57BL/6 wild type (WT) or TNF receptor 1 deficient (TNFR1−/−) mice were inoculated with 1 × 106 PFU of CHIKV in the paw. Alternatively, etanercept was used to inhibit TNF in infected WT mice. Hypernociception, inflammatory and virological analysis were performed. Inoculation of CHIKV into WT mice induced persistent hypernociception. There was significant viral replication in target organs and local production of inflammatory mediators in early time‐points after infection. CHIKV infection was associated with specific humoral IgM and IgG responses. In TNFR1−/− mice, there was a decrease in the hypernociception threshold, which was associated with a milder local inflammatory response in the paw but delayed viral clearance. Local or systemic treatment with etanercept reduced CHIKV‐induced hypernociception. This is the first study to describe hypernociception, a clinical correlation of arthralgia, in immunocompetent mice infected with CHIKV. It also demonstrates the dual role of TNF in contributing to viral clearance but driving tissue damage and hypernociception. Inhibition of TNF may have therapeutic benefits but its role in viral clearance suggests that viral levels must be monitored in CHIKV‐infected patients and that TNF inhibitors should ideally be used in combination with anti‐viral drugs.
Comparison of molecular and serological assays on cerebrospinal fluid for the diagnosis of neurosyphilis
Authors: Salle Romain , Grange Philippe A. , Ollagnier Guillaume , Benhaddou Nadjet , Heller Ugo , Dupin Nicolas 
Published: September 2022

AbstractBackgroundMany assays are available on cerebrospinal fluid (CSF) for the diagnosis of neurosyphilis (NS) but there is no ‘gold standard’.ObjectivesThe aim of this study was to evaluate different molecular and serological assays used in NS.MethodsWe evaluated two PCR assays and three serological techniques in parallel on CSF samples collected between 2019 and 2020 from patients suspected of NS.ResultsThe study included 143 patients comprising 30 early NS, 7 late NS and 106 patients without a diagnosis of NS. All patients with NS were symptomatic and had either neurological (67.6%) or ophthalmological signs (54.1%). The qPCR and nPCR assays had overall sensitivities (Se) of 41% and 27%, respectively; with each an overall specificity (Sp) of 100%. VDRL had a Se of 51% and a Sp of 92%. Immunoblot had a Se of 62% and a Sp of 85%. Finally, treponemal tests (TT) had a Se of 96% and a Sp of 69%.ConclusionsOur study confirms the excellent specificity of molecular techniques allowing to avoid overdiagnosis of NS, and thus, unjustified intensive antibiotic therapy protocols. CSF TT, although not very specific, has an excellent Se confirming that there is almost never NS with negative CSF TT. VDRL and immunoblot tests have better overall diagnostic performance. However, none of these techniques has sufficient diagnostic performance to represent a ‘gold standard’. Thus, the diagnosis of NS relies on a combination of clinical and biological parameters with the association of PCR with serology, associating VDRL and immunoblot, in CSF.
The L‐shape technique in guided bone regeneration with simultaneous implant placement in the esthetic zone: A step‐by‐step protocol and a 2–14 year retrospective study
Authors: Zuercher Anina‐Nives , Mancini Leonardo , Naenni Nadja , Thoma Daniel‐Stefan , Strauss Franz‐Josef , Jung Ronald‐Ernst 
Published: September 2022

AbstractObjectivesTo describe the methodology of the “L‐shape” technique in guided bone regeneration (GBR) with simultaneous implant placement and report on the clinical, esthetic, and patient satisfaction outcomes up to 14 years of follow‐up.Material and methodsFourteen patients treated with the “L‐shape” technique were included in this retrospective study. The L‐shape technique was performed by trimming and placing a soft‐type bone block made of deproteinized bovine bone mineral with 10% collagen at the buccal‐occlusal aspect of the dental implant. The remaining gaps were filled with deproteinized bovine bone mineral granules and the augmented area was covered with a collagen membrane. The following parameters were recorded: probing depth (PD), bleeding on probing (BOP), plaque index (PI), keratinized tissue width (KT) and marginal bone level (MBL). Esthetic outcomes were assessed according to the pink esthetic score (PES) and the white esthetic score (WES). Patient satisfaction was evaluated by means of a numerical rating scale (0–10). The stability of each augmented site was assessed by measuring the volumetric changes between baseline (crown delivery) and the respective follow‐up.ResultsA total of 13 maxillary incisors and one maxillary canine in 14 patients were included. The mean follow‐up period was 7.7 ± 3.8 years. PES values amounted to 10.7 ± 3.3 and WES to 8.8 ± 1.4. Patient satisfaction reached 9.4 ± 0.8. Mean PD at implant sites were 2.7 ± 0.7 mm while BOP amounted to 15.0 ± 0.2% and Pl to 5.0 ± 0.0%. Volumetric analyses revealed minimal changes at the augmented sites irrespective of the region of interest. Radiographic MBL remained relatively stable.ConclusionsWithin the limitation of the present study the L‐shape augmentation procedure seems to be a reliable technique when performing GBR with simultaneous implant placement in the esthetic zone. Outcomes encompassed stable clinical and esthetic results accompanied by high levels of patient satisfaction. Future randomized controlled trials are warranted to confirm possible benefits of the L‐shape technique over traditional approaches.Clinical significanceThe L‐shape appears to be a simple yet promising technique in GBR with simultaneous implant placement that can easily be translated into clinical practice.
Fabrication of the antimicrobial sachet by encapsulation of peppermint essential oil in active packaging of strawberry fruit
Authors: Amiri Azam , Sourestani Mohammad Mahmoodi , Mortazavi Seyed Mohammad Hassan , Kiasat Ali Reza , Ramezani Zahra 
Published: September 2022

AbstractThe anti‐microbial property‐based packaging system is able to destroy and eliminate the contaminants and pathogenic microorganisms, which spoil the food. In this study, sachets were prepared by an active packaging system using starch‐based microcellular foam loaded with peppermint essential oil (SMF‐PEO). The produced SMF was used to make sachets loaded with PEO and then placed on the upper part of the strawberry package. Qualitative and biochemical traits of the strawberry fruits, such as weight loss percentage, vitamin C, phenolic substances, antioxidant capacity, anthocyanin, malondialdehyde, hydrogen peroxide content, microbial load, and antioxidant enzymes activity, were evaluated. Results of the gas chromatography confirmed EO release until the end of the fourth day of the fruit storage. Fourier‐transform infrared spectroscopy spectra showed the porosity of the SMF and the loading of PEO in its pores. Total phenol and antioxidant activity decreased during storage. At the end of storage, the most total antioxidant activity (29.04 iron II mol g−1) was found in packaged fruits with sachet, whereas the most anthocyanin (896 mg kg−1) was found in control. At the end of the storage period, the treated fruits showed a greater catalase (1660 U kg−1) and phenylalanine ammonia‐lyase (1626.6 U kg−1) activity. Packaged fruits with sachet had lower microbial load, total mesophilic bacteria in control and treated samples was 3.7 and 1.7 Log CFU g−1 in end during storage. At the end of storage, the total yeast + mold in treated and control fruits was 1.3 and 1.57 Log CFU g−1, respectively.Practical applicationsThe sachets loaded with PEO increased activity of enzymes and the decreased amount of malondialdehyde have a positive effect on increasing the shelf life of strawberry fruits and are efficient enough to reduce microbial load. Due to the inexpensiveness and degradability of starch, SMF is a suitable system for PEO loading.
Evaluation of using the rice in Mekong Delta for beer making: Nutritional, heat‐resistant, protease‐resistant, and inhibitor properties of proteins
Authors: Hung Nguyen Tan , Thuy Nguyen Thi , Ha Nguyen Cong 
Published: September 2022

AbstractThe aim of this study was to evaluate whether IR50404‐resistant protein (RP) rice is suitable for brewing. So, the RP was soaked in water pH 6.6 at room temperature for 24 h and germinated for 4 days to get green malt. This malt was dried at 50°C for 24 h to get rice malt (RM). The RM was mashed with an adjusted EBC program before being fermented by yeast at 13°C for 4 days to get rice beer (RB). The results showed that protein in RM showed a statistical difference in inhibitory zone diameter for proteinase K, which is similar to barley malt. Heat‐ and protease‐resistant proteins (HPRPs) in RM were ranged between 14.4 and 55–70 kDa. The HPRPs were detected as an alpha‐amylase/trypsin inhibitor (~14.4 kDa) in wort and RB. The beer foam was stable from 5 to 25 min after shacking. Therefore, IR50404 contains HPRPs that contribute to the stability of the foam of the RB.Novelty impact statementIt is necessary to find a method to determine the possibility of a rice variety in the Mekong Delta region can be used for beer making. This study focused on the heat‐ and protease‐resistant/inhibitor properties of the protein because the brewing process is always accompanied by heating and the presence of protease from yeast. So, the presence of these proteins group during malting and after beer fermentation could contribute to the stability of clarification as well as foam establishment and foam stability of rice beer. The results of this study indicate that the rice variety IR50404 was completely usable for beer making. This property is also an indicator for selecting rice that is suitable for beer making.
HY5‐HDA9 orchestrates the transcription of HsfA2 to modulate salt stress response in Arabidopsis
Authors: Yang Jiaheng , Qu Xiao , Li Tao , Gao Yixiang , Du Haonan , Zheng Lanjie , Ji Manchun , Zhang Paifeng , Zhang Yan , Hu Jinxin , Liu Liangyu , Lu Zefu , Yang Zijian , Zhang Huiyong , Yang Jianping , Jiao Yongqing , Zheng Xu 
Published: September 2022

ABSTRACTIntegration of light signaling and diverse abiotic stress responses contribute to plant survival in a changing environment. Some reports have indicated that light signals contribute a plant's ability to deal with heat, cold, and stress. However, the molecular link between light signaling and the salt‐response pathways remains unclear. We demonstrate here that increasing light intensity elevates the salt stress tolerance of plants. Depletion of HY5, a key component of light signaling, causes Arabidopsis thaliana to become salinity sensitive. Interestingly, the small heat shock protein (sHsp) family genes are upregulated in hy5‐215 mutant plants, and HsfA2 is commonly involved in the regulation of these sHsps. We found that HY5 directly binds to the G‐box motifs in the HsfA2 promoter, with the cooperation of HISTONE DEACETYLASE 9 (HDA9), to repress its expression. Furthermore, the accumulation of HDA9 and the interaction between HY5 and HDA9 are significantly enhanced by salt stress. On the contrary, high temperature triggers HY5 and HDA9 degradation, which leads to dissociation of HY5‐HDA9 from the HsfA2 promoter, thereby reducing salt tolerance. Under salt and heat stress conditions, fine tuning of protein accumulation and an interaction between HY5 and HDA9 regulate HsfA2 expression. This implies that HY5, HDA9, and HsfA2 play important roles in the integration of light signaling with salt stress and heat shock response.
What are the qualitative experiences of people affected by kidney failure receiving haemodialysis?
Authors: McKie Amanda L. , Turner Murray , Paterson Catherine 
Published: September 2022

AbstractBackgroundPeople affected by kidney failure receiving haemodialysis experience complexity within their health condition unlike any other chronic illness or condition. Kidney failure impacts the individual in all areas of their life including relationships and activities of daily living.ObjectiveTo conduct a meta‐aggregation of studies about the lived experiences of people with kidney failure receiving haemodialysis.DesignUsing PRISMA Guidelines, six databases (CINAHL, ClinicalTrials.gov, Cochrane Library, MEDLINE, PsycINFO, and Scopus) were comprehensively searched using keywords and subject headings from January 1990 to October 2021. Articles were assessed according to prespecified eligibility criteria. Data extraction and quality appraisal was conducted. A meta‐aggregation of qualitative findings was conducted using the Joanna Briggs Institute methodology for meta‐aggregation.ResultsOf the 9409 articles screened, 55 studies were included. This represented a total of 188 findings across 45 categories representing a range of unmet supportive care needs. The meta‐aggregation identified 11 synthesised findings broadly related to psychological/emotional needs, physical needs, social needs, interpersonal/intimacy needs, patient‐clinician communication needs, family related needs, health system/information needs, spiritual needs, daily living needs, practical needs and daily living needs.ConclusionsThis meta‐aggregation has identified that people affected by kidney failure can experience a range of unmet supportive care needs. It was evident that living with kidney failure and receiving haemodialysis impacted a person's sense of self, introduced practical needs and other complex needs which were not being addressed in existing services. This review has highlighted important implications for clinical practice and future research directions.
On the cost‐of‐capital rate under incomplete market valuation
Authors: Albrecher Hansjörg , Eisele Karl‐Theodor , Steffensen Mogens , Wüthrich Mario V. 
Published: September 2022

AbstractIn this paper we discuss the concept of the cost‐of‐capital (CoC) rate for an insurance company as an equilibrium in the economic triangle of policyholders, shareholders, and the regulator. This provides a possible rationalization and an economic foundation for a quantity that is widely used in practice but whose value is typically neither technically nor economically well justified. We show how it can be well founded in such a triangular equilibrium. Under a simple one‐period model and a valuation procedure of a two‐price economy for illiquid assets we provide a corresponding economic‐theoretical quantification for the CoC rate. The resulting rates are illustrated by a number of concrete numerical examples.
Well‐being of migrants and immigrants: Perspectives in Asia and from Asians in North America
Authors: Tong Yuying , Fong Eric 
Published: September 2022

AbstractImmigrant and migrant well‐being have been widely studied, but the knowledge gained from immigrant adaptation and well‐being has mostly focused on findings from more developed countries, which may diverge from the situation in Asia. East‐Asian countries have strong roots in Confucian culture, which celebrates cultural homogeneity, and societies are thus conservative when it comes to welcoming immigrants. Southeast Asian countries are major migrant‐sending areas but have now also become important manufacturing centers with dynamic migrant and immigrant groups. In this special issue, we seek to push forward knowledge about the myth of immigrant and migrant adaptation and well‐being among both Asian areas and Asian immigrants in North America. In this introductory article, we first discuss a few gaps in research on migration and immigration in Asia, including migration of the same ethnicity group across different political systems in the Asian context, migration and its influence on family and well‐being between and among Southeast Asian countries, as well as Asian immigrants in North America. We then introduce the various contributions to this special issue. We conclude with a discussion of policy implications.
Putin, national self‐determination and political independence in the twenty‐first century
Authors: Girvin Brian 
Published: September 2022

AbstractThis contribution focuses on the right of nations to self‐determination after the Russian invasion of Ukraine. It suggests that sovereignty and territorial integrity are not as secure as once thought. A number of articles and statements issued by Vladimir Putin are analysed to identify nationalist themes which he uses to reject Ukraine's right to exist outside the Russian state. Key themes include a primordial account of national origins, the conflation of state and nation, and a refusal to recognise a right to self‐determination of territories that had once been part of Russia. Putin's nationalism draws on imperial nationalism, state nationalism, revanchism and majoritarianism to underwrite his claims. Such views are widespread among established states, contributing to the instability of the contemporary world. It is argued that a reconfiguration of the relationship between state and nation is long overdue, as is the inflexible nature of territorial integrity.