bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators to overactive bladder therapy adherence
Authors: Enemchukwu Ekene A. , Subak Leslee L. , Markland Alayne 
Published: May 2022

AbstractAimsTo provide an overview of the barriers and facilitators to overactive bladder (OAB) therapy initiation and adherence.MethodsA PubMed and Embase literature search was conducted to identify barriers to OAB therapy adherence.ResultsOAB therapy adherence is associated with improvements in urinary symptoms, and quality of life with reductions in annual costs for OAB‐related expenditures. However, adherence rates to behavioral therapies are as low as 32% at 1 year, only 15%‐40% of treated patients remain on oral medications at 1 year due to several factors (e.g., inadequate efficacy, tolerability, and cost), and 5%−10% of OAB patients progress to advanced therapies. While some common barriers to therapy adherence are often fixed (e.g., costs, lack of efficacy, time, side effects, treatment fatigue), many are modifiable (e.g., lack of knowledge, poor relationships, negative experiences, poor communication with providers). Patient‐centered care may help address some modifiable barriers. Emerging data demonstrate that patient‐centered care in the form of treatment navigators improves OAB therapy adherence and progression to advanced therapies in the appropriate patient.ConclusionsThere are numerous modifiable barriers to OAB therapy adherence. A patient‐centered lens is needed to elicit patient goals, establish realistic treatment expectations, and tailor therapy to improve therapy adherence, optimize outcomes, and reduce healthcare expenditures. Further research is needed to develop and study low‐cost, scalable solutions.
High‐throughput whole‐slide scanning to enable large‐scale data repository building
Authors: Zarella Mark D , Rivera Alvarez Keysabelis 
Published: May 2022

AbstractDigital pathology and artificial intelligence (AI) rely on digitization of patient material as a necessary first step. AI development benefits from large sample sizes and diverse cohorts, and therefore efforts to digitize glass slides must meet these needs in an efficient and cost‐effective manner. Technical innovation in whole‐slide imaging has enabled high‐throughput slide scanning through the coordinated increase in scanner capacity, speed, and automation. Combining these hardware innovations with automated informatics approaches has enabled more efficient workflows and the opportunity to provide higher‐quality imaging data using fewer personnel. Here we review several practical considerations for deploying high‐throughput scanning and we present strategies to increase efficiency with a focus on quality. Finally, we review remaining challenges and issue a call to vendors to innovate in the areas of automation and quality control in order to make high‐throughput scanning realizable to laboratories with limited resources. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Intuitive endoscopic robot master device with image orientation correction
Authors: Cheon Byungsik , Kim Chang‐Kyun , Kwon Dong‐Soo 
Published: May 2022

AbstractBackgroundThe camera of an endoscope is fixed to the device, and the image rotates together with the endoscope. This can lead to visual confusion for the user and incorrect image reading. The problem also occurs with endoscopic robots. Using a master device with the same degrees of freedom as the endoscope to control an endoscopic robot causes visual‐motor misorientation, making intuitive control difficult.MethodsThe roll misorientation between the image and master device handle was removed by measuring and correcting for the roll axis displacement of the master device. This enabled intuitive manipulation of the master device. The work speed and number of mistakes were experimentally measured with and without image correction.ResultsThe tasks were completed significantly faster and more accurately with image orientation correction than without.ConclusionsThe proposed method enables intuitive manipulation of the master device by correcting the image orientation in endoscopic robot control.
Insight into the Enterovirus A71: A review
Authors: Kinobe Robert , Wiyatno Ageng , Artika I. Made , Safari Dodi 
Published: May 2022

AbstractEnterovirus A71 is a major causative pathogen of hand, foot and mouth disease. It has become a global public health threat, and is especially important for infants and young children in the Asian‐Pacific countries. The enterovirus A71 is a non‐enveloped virus of the Picornaviridae family having a single‐stranded positive‐sense RNA genome of about 7.4 kb which encodes the structural and nonstructural proteins. Currently there are no US FDA‐approved vaccines or antiviral therapy available against enterovirus A71 infection. Although enterovirus A71 vaccines have been licenced in China, clinically approved vaccines for widespread vaccination programs are lacking. Substantial progress has recently been achieved on understanding the structure and function of enterovirus A71 proteins together with information on the viral genetic diversity and geographic distribution. The present review is intended to provide an overview on our current understanding of the molecular biology and epidemiology of enterovirus A71 which will aid the development of vaccines, therapeutics and other control strategies so as to bolster the preparedness for future enterovirus A71 outbreaks.
Surface‐enhanced Raman scattering: An emerging tool for sensing cellular function
Authors: Tanwar Swati , Kim Jeong Hee , Bulte Jeff W. M. , Barman Ishan 
Published: May 2022

AbstractContinuous long‐term intracellular imaging and multiplexed monitoring of biomolecular changes associated with key cellular processes remains a challenge for the scientific community. Recently, surface‐enhanced Raman scattering (SERS) has been demonstrated as a powerful spectroscopic tool in the field of biology owing to its significant advantages. Some of these include the ability to provide molecule‐specific information with exquisite sensitivity, working with small volumes of precious samples, real‐time monitoring, and optimal optical contrast. More importantly, the availability of a large number of novel Raman reporters with narrower full width at half maximum (FWHM) of spectral peaks/vibrational modes than conventional fluorophores has created a versatile palette of SERS‐based probes that allow targeted multiplex sensing surpassing the detection sensitivity of even fluorescent probes. Due to its nondestructive nature, its applicability has been recognized for biological sensing, molecular imaging, and dynamic monitoring of complex intracellular processes. We critically discuss recent developments in this area with a focus on different applications where SERS has been used for obtaining information that remains elusive for conventional imaging methods. Current reports indicate that SERS has made significant inroads in the field of biology and has the potential to be used for in vivo human applications.This article is categorized under:
Diagnostic Tools > In Vitro Nanoparticle‐Based Sensing
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Diagnostic Tools > Biosensing
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Hurricane effects on wild turkey survival, daily movements, and roost fidelity
Authors: Moscicki David J. , Gerrits Alaina P. , Cantrell Jay R. , Hardin Jason B. , Chamberlain Michael J. , Collier Bret A. 
Published: May 2022

AbstractEnvironmental disturbances driven by global climate variability continue to increase in both frequency and intensity. Recent studies on wild turkeys (Meleagris gallopavo) have documented both direct and indirect demographic effects of short‐term, climatically driven events; however, only limited information is available on the effects of extreme environmental disturbance events on turkey demography. Thus, we evaluated space use and movements of eastern wild turkeys (M. g. silvestris; n = 20) and Rio Grande wild turkeys (M. g. intermedia; n = 22) during hurricane events in South Carolina and Texas, respectively. Hurricane Matthew occurred over a 3‐day period in October 2016 impacting ongoing turkey research on the Webb Wildlife Management Area Complex in South Carolina, whereas Hurricane Harvey occurred over a 5‐day period in August 2017 impacting an ongoing 6‐county study region in Texas. We documented 1 and 2 direct mortalities during Hurricanes Matthew and Harvey, respectively. Mean core area size used by turkeys decreased by 75% during both hurricane events. We did not document evidence of changes in roost fidelity or distance between daily roost clusters after either hurricane. We documented direct mortality of 5 and 8% of the study population during Matthew and Harvey, respectively, and turkeys exhibited a gradient of behavioral responses dependent on hurricane intensity and duration. Because hurricanes can produce substantive modifications to areas used by wild turkeys, we suggest that managers consider initiatives to document legacy effects of extreme environmental disturbance events on local wild turkey demographics, including loss of nesting, brooding and roosting sites.
Nest site fidelity and nesting success of female wild turkeys
Authors: Byrne Michael E. , Cohen Bradley S. , Collier Bret A. , Chamberlain Michael J. 
Published: May 2022

AbstractNest site fidelity is a common behavioral trait among birds that can positively influence reproductive success when there is spatial heterogeneity and temporal predictability in nest site quality. Nest site fidelity in wild turkeys (Meleagris gallopavo) has received little attention in the literature despite providing a potential link to nesting success. We used data from 32 female wild turkeys across 8 field sites ranging from South Carolina to Texas with 2 consecutive years of nest data to determine if females showed fidelity to nest sites, if distance between nest locations in consecutive years predicted nest success in the second year, and if females showed fidelity to specific areas within home ranges (patches) for nesting. Females tended to nest closer to previously successful nests (median distance = 920 m) than to unsuccessful nests (median distance = 1550 m) in the second year; however, we documented no evidence of fidelity to specific nest sites. There was widespread reuse of prelaying (89.5%) and laying (77.8%) ranges by females between years, indicating some evidence for patch fidelity. The lack of evidence for nest site fidelity may be a result of the temporally dynamic nature of turkey nesting cover and ubiquity of predation risk across the southeastern U.S, which ecological theory predicts would not provide the reproductive benefits of fidelity that hinge on predictability. Fidelity to patches within home ranges may represent an always‐stay approach, which is expected when the cost of dispersing to new breeding areas outweighs potential benefits and may allow females to draw on prior knowledge of areas within their home ranges. Although distance between nests was not a significant predictor of nest success, females that nested successfully in the first year had a probability of 0.63 of successfully nesting in the second year, whereas unsuccessful females had probability of success of 0.08 in the second year. The tracking of individual nesting success across years warrants further research, as our results imply that a disproportionate percentage of reproduction through time may be attributed to a subset of females that are consistently successful, which may have implications for our understanding of reproductive dynamics in low productivity populations.
Breeding season survival of female Rio Grande wild turkeys in south‐central Texas
Authors: White Jacob H. , Moscicki David J. , Jobes Doug , Hardin Jason B. , Chamberlain Michael J. , Collier Bret A. 
Published: May 2022

AbstractHistorically, Rio Grande wild turkey (Meleagris gallopavo intermedia) density in south‐central Texas has been lower than other regions within the species' Texas range. Within the Oak‐Prairie Wildlife District of Texas, Rio Grande wild turkey harvest regulations are more restrictive for counties in the eastern portion of the district. Due to a perceived increase in turkey density in the eastern portion of the district, Texas Parks and Wildlife Department (TPWD) has considered increasing the spring hunting season harvest bag limit. Because estimates of sex‐specific abundance and male harvest rates are not available, estimates of female driven population parameters such and nest success and female survival can be used to support regulatory decision‐making. Therefore, before a regulation change we evaluated survival of radio‐marked female Rio Grande wild turkeys during the breeding season in 4 counties in the Special 1‐Male zone (hereafter 1‐bird zone) and 2 counties in the South zone (hereafter 4‐bird zone). We captured and monitored breeding season survival for 138 females during 2016–2018, of which 51 were in the 4‐bird zone and 87 were in the 1‐bird zone. Breeding season (1 Mar–14 Aug) naive mortality rate was 23% (19/81) of tagged females in the 1‐bird zone and 32% (14/43) in the 4‐bird zone. The best approximating candidate model for breeding season survival indicated variation in daily survival () was primarily related to daily distance of individual movements ( = 0.998 at average daily distance of 2,471 m). Estimated breeding season survival at the mean daily movement distance was 81% for the 167‐day period. Breeding season survival was similar between the 1‐bird and 4‐bird regulatory zone. Based on our results, female breeding season survival does not seem to be a limiting factor within the Oak‐Prairie Wildlife District of Texas for Rio Grande wild turkeys. We suggest that TPWD focus efforts on supporting landowners to enhance conditions more conducive for reproductive success and suggest future efforts focus on collection of harvest and harvest rate data to estimate population size in lieu of continued monitoring of female reproductive or survival parameters for decision processes.
Child Health in Southeast Asia
Authors: Yeung Wei-Jun Jean 
Published: May 2022

AbstractIn the past three decades, the Southeast Asian countries have made efforts in improving child health and have seen great progress in protecting people from diseases via vaccination. It is attributable to the concerted effort by nations and global organizations, such as the WHO guidelines on nutrition for the management of severe malnutrition and overnutrition, and the National Immunization Programme (NIP) to prevent a range of diseases.
Water-Filtered Infrared A Irradiation in Clinical Dermatology
Authors: Jauker P. , Wolf P. , Tanew A. 
Published: May 2022

AbstractSo far, wIRA has primarily been used in the following dermatological conditions: wound healing, sclerosing skin diseases and common cutaneous warts. Accelerated healing of both acute (e.g., after surgery) and chronic (e.g., venous ulcers) wounds has been described in case reports, small case series and a randomized controlled trial. wIRA not only reduced pain and inflammation but also influenced wound secretion. It has also been shown to protect against infection and promote the formation of granulation tissue and wound re-epithelialisation. The therapeutic efficacy of wIRA in localized scleroderma and sclerotic cutaneous graft-versus-host disease is currently under investigation in a prospective Austrian two-center study. Previous reports on sclerosing skin disorders have indicated that wIRA might arrest disease activity, reduce skin sclerosis and improve joint motility. Finally, anecdotal evidence in immune-compromised twins and a randomized controlled trial on 80 patients have shown that wIRA might induce erradication of treatment-resistant common warts.wIRA appears to be a promising treatment approach for some challenging dermatological skin disorders. The treatment is easy to perform and devoid of any serious acute and chronic side effects. wIRA is well-accepted, since it generates a pleasant sensation in the skin.
Molecular and Cellular Mechanisms of Water-Filtered IR
Authors: Hamblin Michael R. 
Published: May 2022

AbstractWater-filtered infrared A (wIRA) has been used to produce tissue hyperthermia to treat cancer, but also to treat a variety of other conditions, such as wound healing, pain, and inflammation. While the mechanism of anti-cancer hyperthermia is well-established, the mechanism of wIRA to promote healing and pain reduction is less clear. In this chapter, I will cover the use of photobiomodulation to treat several conditions characterized by mitochondrial dysfunction. Next the role of heat-sensitive transient receptor potential (TRP) ion channels is discussed, with regard to nitric oxide production and infrared neural stimulation. Then the use of infrared emitting bioceramic nanoparticles embedded in garments or patches, which are powered solely by body heat to promote healing and reduce pain and inflammation is discussed. The conclusion is that wIRA can activate heat-sensitive TRP channels, possibly mediated by energy absorption by nanostructured water clusters, leading to many of the observed therapeutic benefits.
Gold Nanoparticles and Infrared Heating: Use of wIRA Irradiation
Authors: Hainfeld J. F. , Smilowitz H. M. 
Published: May 2022

AbstractwIRA-transparent small gold nanoparticles (AuNPs) were shown to be shifted to wIRA absorbing when targeted to receptors on tumor cells and aggregated in the tumor cell by enzyme degradation and pH effects. In this way, AuNPs loaded into mouse-grown subcutaneous tumors after both direct intratumoral and intravenous injections cured tumors after either wIRA treatment ablation or wIRA treatment combined with X-ray irradiation. Some GNP constructs, e.g., nanoshells and nanorods, have already progressed to veterinary and human clinical trials. If AuNP/NIR therapy is proven to be useful to treat an appropriately superficial human tumor, the use of the wIRA radiator might make such therapy accessible to large numbers of patients in low- and middle-income countries that lack access to very high-tech expensive therapies.
Stand der Technik
Authors: Wild Jochen 
Published: May 2022

ZusammenfassungWie Kapitel 1.1 entnommen werden kann, ist die geometrische Optimierung evolventisch basierter Zahnwellenverbindungen für das Kriterium der Gestaltfestigkeit das mit dieser Dissertation übergeordnet zu lösende Problem. Zu optimieren sind jedoch explizit nicht die dem Stand der Technik entsprechenden Verbindungen nach [DIN 5480]. Kann mit ihnen doch mitnichten das volle Gestaltfestigkeitspotenzial evolventisch basierter Zahnwellenverbindungen genutzt werden. Hier leistet das in Kapitel 3.2 entwickelte und in Kapitel 3.3 zur einfachen Anwendung dargelegte System zur Profilgenerierung Abhilfe. Es sind die diesem System entstammenden Verbindungen, deren Optimierung Ziel des vorliegenden Werkes ist.
Geometriebezogene Definitionen, Entwicklungen und Betrachtungen
Authors: Wild Jochen 
Published: May 2022

ZusammenfassungGegenstand der geometriebezogen getroffenen Definitionen, realisierten Entwicklungen und durchgeführten Betrachtungen ist zunächst die kritische Analyse sowohl der Systematik als auch des Systems zur Bezugsprofilgenerierung evolventisch basierter Zahnwellenverbindungen der [DIN 5480]. Im Rahmen dieser werden funktionale Probleme und geometrische Restriktionen aufgezeigt. Möglichkeiten zur mathematischen Vereinfachung werden ausgearbeitet. Wie unter anderem in Kapitel 1.2 dargelegt, sind allerdings die ebenfalls dort formulierten Zielsetzungen dieser Dissertation nicht mit dem System zur Bezugsprofilgenerierung evolventisch basierter Zahnwellenverbindungen der [DIN 5480] realisierbar.
Optimierung der Grundform
Authors: Wild Jochen 
Published: May 2022

ZusammenfassungWesentlicher Bestandteil dieser Dissertation ist die Optimierung evolventisch basierter Zahnwellenverbindungen nach Kapitel 3.3 mit quasi endlos verzahnter Welle für das Kriterium der Gestaltfestigkeit, wobei Nabenbreite $$b$$
b
sowie Nabenrestwandstärke so gewählt sind, dass sie ihrem jeweils asymptotischen Einflussbereich entstammen, vgl. Kapitel 2.5.1. Derartige Verbindungen werden in diesem Werk als Grundform evolventisch basierter Zahnwellenverbindungen bezeichnet. Ihre exakte Definition ist essenziell und demnach Gegenstand von Kapitel 6.1.
Boundary conditions for warped AdS3 in quadratic ensemble
Authors: Aggarwal Ankit , Ciambelli Luca , Detournay Stéphane , Somerhausen Antoine 
Published: May 2022

Abstract
In the context of warped conformal field theories (WCFT), the derivation of the warped Cardy formula relies on the zero mode spectrum being bounded from below. Generically, this is not true for holographic WCFTs in “canonical” ensemble, whereas this condition is satisfied in the “quadratic” ensemble, making it more natural in holographic setups. In this work, we find a new set of boundary conditions in three-dimensional Topologically Massive Gravity (TMG) such that the putative dual theory is a WCFT in quadratic ensemble. Surprisingly, imposing the equations of motion, we obtain a closed form metric spanned by two arbitrary chiral functions, analogous to the Bañados metrics in Einstein gravity. Surface charges for these boundary conditions are not a priori integrable and we discuss two choices of boundary conditions to make them so. We obtain the bulk thermodynamic entropy of warped BTZ black holes by making use of the warped Cardy formula, in its regime of validity. We also discuss the issue of identifying the vacuum in our solution space: demanding the enhancement of global symmetries selects only a family of solutions, out of which the unique vacuum must be carefully singled out.
Pole inflation from non-minimal coupling to gravity
Authors: Karamitsos Sotirios , Strumia Alessandro 
Published: May 2022

Abstract
Transforming canonical scalars to the Einstein frame can give a multi-field generalization of pole inflation (namely, a scalar with a divergent kinetic term) at vanishing field-dependent Planck mass. However, to obtain an attractor, the scalar potential must obey certain non-generic conditions. These are automatically satisfied in Quantum Field Theories with dimension-less couplings. The resulting models of pole inflation have special inflationary predictions determined by the full RG running of couplings. Acceptable predictions for the tensor/scalar ratio arise for perturbative but moderately large couplings, so we explore the possible QFT runnings: to confinement, to an IR fixed point, and to a UV fixed point.
On-shell correlators and color-kinematics duality in curved symmetric spacetimes
Authors: Cheung Clifford , Parra-Martinez Julio , Sivaramakrishnan Allic 
Published: May 2022

Abstract
We define a perturbatively calculable quantity — the on-shell correlator — which furnishes a unified description of particle dynamics in curved spacetime. Specializing to the case of flat and anti-de Sitter space, on-shell correlators coincide precisely with on-shell scattering amplitudes and boundary correlators, respectively. Remarkably, we find that symmetric manifolds admit a generalization of on-shell kinematics in which the corresponding momenta are literally the isometry generators of the spacetime acting on the external kinematic data. These isometric momenta are intrinsically non-commutative but exhibit on-shell conditions that are identical to those of flat space, thus providing a common language for computing and representing on-shell correlators which is agnostic about the underlying geometry. Afterwards, we compute tree-level on-shell correlators for biadjoint scalar (BAS) theory and the nonlinear sigma model (NLSM) and learn that color-kinematics duality is manifested at the level of fields under a mapping of the color algebra to the algebra of gauged isometries on the spacetime manifold. Last but not least, we present a field theoretic derivation of the fundamental BCJ relations for on-shell correlators following from the existence of certain conserved currents in BAS theory and the NLSM.