bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controlled Optoelectronic Response in van der Waals Heterostructures for In‐Sensor Computing
Authors: Yang Qiyu , Luo Zheng‐Dong , Zhang Dawei , Zhang Mingwen , Gan Xuetao , Seidel Jan , Liu Yan , Hao Yue , Han Genquan 
Published: August 2022

AbstractIn‐sensor computing with visual information, which can integrate photo‐sensing, data storage, and computation functions within the same physical element, has promised a fundamentally different architecture for future machine vision technology with extreme energy and time efficiency. The elementary devices required to fulfil the goal of such a new sensory computation scheme would demand a bold functional variation to the existing sensor and data processing hardware. Here, a van der Waals (vdW) heterostructure‐based optoelectronic transistor that can act as an integrated photoreceptor, memory, and computation unit by exploiting its own physical attributes is demonstrated. It is found that diverse photoelectric control of device conductance can lead to versatile photoresponse characteristics, including memristive behaviors, retention‐, polarity‐ and strength‐tunable photoconductance, photoelectric‐coupling effect, etc. Exploiting the photoelectric‐coupling effect, reconfigurable and nonvolatile optoelectronic logic functions are realized in this device, featuring a logic‐in‐sensor unit. With the same device, both short‐ and long‐term synaptic plasticity can be faithfully emulated, rendering it an optoelectronic synaptic transistor. Moreover, a psychologic human memory model is implemented with the device, showing the emulation of memorization and learning processes. This prototypical demonstration provides a promising hardware system for visual information in‐sensor computing capable of addressing complex computation tasks.
Physiology‐Inspired Multilayer Nanofibrous Membranes Modulating Endogenous Stem Cell Recruitment and Osteo‐Differentiation for Staged Bone Regeneration
Authors: Mao Yingji , Chen Yu , Li Weifeng , Wang Ying , Qiu Jingjing , Fu Yingxiao , Guan Jianzhong , Zhou Pinghui 
Published: August 2022

AbstractBone regeneration involves a cascade of sophisticated, multiple‐staged cellular and molecular events, where early‐phase stem cell recruitment mediated by chemokines and late‐phase osteo‐differentiation induced by pro‐osteogenic factors play the crucial roles. Herein, enlightened by a bone physiological and regenerative mechanism, the multilayer nanofibrous membranes (PLLA@SDF‐1α@MT01) consisting of PLLA/MT01 micro‐sol electrospun nanofibers as intima and PLLA/PEG/SDF‐1α electrospun nanofibers as adventitia are fabricated through micro‐sol electrospinning and manual multi‐layer stacking technologies. In vitro releasing profiles show that PLLA@SDF‐1α@MT01 represents the rapid release of stromal cell‐derived SDF‐1α (SDF‐1α) in the outer layers, while with long‐term sustained release of MT01 in the inner layer. Owing to interconnected porosity like the natural bone extracellular matrix and improved hydrophilia, PLLA@SDF‐1α@MT01 manifests good biocompatibility both in vitro and in vivo. Furthermore, PLLA@SDF‐1α@MT01 can promote bone marrow mesenchymal stem cells (BMSCs) migration by amplifying the SDF‐1α/CXCR4 axis and stimulating BMSCs osteo‐differentiation via activating the MAPK pathway in vitro. PLLA@SDF‐1α@MT01, with a programmed dual‐delivery system, exhibits the synergetic promotion of bone regeneration and vascularization by emulating key characteristics of the staged bone repair in vivo. Overall, PLLA@SDF‐1α@MT01 that mimics the endogenous cascades of bone regeneration can enrich the physiology‐mimetic staged regenerative strategy and represent a promising tissue‐engineered scaffold for the bone defect.
Tuning of Surface Charge of Functionalized Poly(Carboxybetaine) Brushes Can Significantly Improve Label‐Free Biosensing in Complex Media
Authors: Víšová Ivana , Houska Milan , Spasovová Monika , Forinová Michala , Pilipenco Alina , Mezuláníková Kateřina , Tomandlová Markéta , Mrkvová Kateřina , Vrabcová Markéta , Dejneka Alexandr , Dostálek Jakub , Vaisocherová‐Lísalová Hana 
Published: August 2022

AbstractPoly(carboxybetaine) brushes are excellent antifouling platforms allowing facile functionalization with biorecognition elements via carbodiimide/N‐hydroxysuccinimide (EDC/NHS) chemistry. However, residual active NHS esters and the loss of zwitterionic balance after the conjugation may impair initially excellent antifouling properties. This problem has so far been addressed either by using spontaneous hydrolysis or deactivation of residual NHS esters by the reaction with a small amino compound bearing hydroxyl or carboxyl groups. In contrast to this approach, and instead of using a single deactivator, here the use of tailored mixtures of deactivating agents containing carboxyl groups and sulfo or sulfate groups with permanent negative charge that allow to tune surface charge balance is investigated. The approach is applied to poly(carboxybetaine acrylamide) (pCBAA) and copolymer of carboxybetaine methacrylamide with N‐(2‐hydroxypropyl) methacrylamide [p(CBMAA‐co‐HPMAA)]. The fouling from undiluted blood plasma or crude minced meat is suppressed by one order of magnitude compared to commonly used deactivation protocols, while the label‐free surface plasmon resonance detection of E.coli O157:H7 in crude minced meat shows the limit of detection improved by two orders of magnitude (3.2 × 103 CFU mL−1 in a direct detection assay format). The reported approach may be applied to other zwitterionic platforms which suffer from impaired antifouling properties after the platform modifications.
Molecular Diodes With Tunable Threshold Voltage Based on π‐Extended Tetrathiafulvalene
Authors: Lin Jin‐Liang , Cao Zhou , Bai Xiyue , Chen Ningyue , Li Chengtai , Xiao Xunwen , Wang Lejia , Li Yuan 
Published: August 2022

AbstractIt is a challenge to control the threshold voltage (defined as the voltage at which the current density increases sharply in the direction of forward bias), one of the basic parameters that define a molecular diode. The problem is that strong Fermi‐level pinning of molecular frontier orbitals and the changes in the electronic structure are often overshadowed by the changes in the supramolecular structure. A chemical control approach is proposed to shift the effective threshold voltage of a series of molecular diodes composed of self‐assembled monolayers (SAMs) of π‐extended tetrathiafulvalene (exTTF) derivatives. The highest occupied molecular orbital of the molecules can be tuned by ≈0.6 eV (maximum) with the minimum changes in the supramolecular structure of the SAMs by introducing chlorine atoms or amino substitutional groups into the exTTF moieties. To the best of the authors’ knowledge, this is the first paper that reports that the threshold voltage of the exTTF‐based diode can be modulated from 0.65 to 1.70 V. In addition, it is shown that these four molecular diodes can operate as half‐wave rectifiers with the threshold voltage at positive direct current output ranging from 1.63 to 2.40 V, with the input voltage being 3.0 V at 500 Hz.
Molecular Orientation‐Induced Polarization Filtering based on Organic Heterostructures
Authors: Liu Kun , De Jianbo , Liang Qian , Liao Qing , Fu Hongbing 
Published: August 2022

AbstractDemonstration of efficient polarization‐signal filtering induced by molecular orientation in organic heterostructures remains elusive. Herein, an epitaxial growth technology is developed for blue‐emissive horizontal p‐distyrylbenzene (DSB) nanosheet (NS) arrays on 9,10‐dicyanoanthracene (DCA)‐dominated (DCA)1‐x(DSB)x doped nanowire (NW) backbone via a facile stepwise solution‐processed method. It is shown that the DSB NS arrays generate blue amplified spontaneous emission (ASE), whereas the backbone of the (DCA)1‐x(DSB)x displays intense yellow emission. Surprisingly, the blue ASE can effectively propagate in (DCA)1‐x(DSB)x backbone immunity to DCA absorption and realize polarization filtering of output ASE. The mechanism of the orthogonal polarization between blue‐ASE from branches and absorption of DCA molecules in the backbone is responsible for the efficient transport of higher‐energy photons in narrow‐gap emitters. This molecular orientation‐induced polarized‐light transport can serve to control light propagation and function as polarization filter in a single heterostructure. The research provides an interesting example for the exploration of novel all‐optical switch devices in photonic circuits.
Chiral Nanoparticles Force Neural Stem Cell Differentiation to Alleviate Alzheimer's Disease
Authors: Shi Baimei , Zhao Jing , Xu Zhuojia , Chen Chen , Xu Liguang , Xu Chuanlai , Sun Maozhong , Kuang Hua 
Published: August 2022

AbstractThe differentiation of neural stem cells via nanomaterials has attracted attention and has become a potential tool. However, the chirality effect in neural stem cell differentiation has not been investigated. Here, this study shows that chiral nanoparticles (NPs) with strong chirality can efficiently accelerate the differentiation of mouse neural stem cells (NSCs) into neurons under near‐infrared (NIR) light illumination. L‐type NPs are 1.95 times greater than D‐type NPs in promoting NSCs differentiation due to their 1.47‐fold endocytosis efficiency. Whole gene expression map analysis reveals that circularly polarized light illumination and chiral NPs irradiation significantly upregulate Map2, Yap1, and Taz genes, resulting in mechanical force, cytoskeleton protein action, and accelerated NSCs differentiation. In vivo experiments show that successful differentiation can further alleviate symptoms in Alzheimer's disease mice. Moreover, the clearance of L‐type NPs on amyloid and hyperphosphorylated p‐tau protein reachs 68.24% and 66.43%, respectively, under the synergy of NIR irradiation. The findings suggest that strong chiral nanomaterials may have advantages in guiding cell development and can be used in biomedicine.
Structural and Optical Properties of High Entropy (La,Lu,Y,Gd,Ce)AlO3 Perovskite Thin Films
Authors: Corey Zachary J. , Lu Ping , Zhang Guangran , Sharma Yogesh , Rutherford Bethany X. , Dhole Samyak , Roy Pinku , Wang Zhehui , Wu Yiquan , Wang Haiyan , Chen Aiping , Jia Quanxi 
Published: August 2022

AbstractMixtures of Ce‐doped rare‐earth aluminum perovskites are drawing a significant amount of attention as potential scintillating devices. However, the synthesis of complex perovskite systems leads to many challenges. Designing the A‐site cations with an equiatomic ratio allows for the stabilization of a single‐crystal phase driven by an entropic regime. This work describes the synthesis of a highly epitaxial thin film of configurationally disordered rare‐earth aluminum perovskite oxide (La0.2Lu0.2Y0.2Gd0.2Ce0.2)AlO3 and characterizes the structural and optical properties. The thin films exhibit three equivalent epitaxial domains having an orthorhombic structure resulting from monoclinic distortion of the perovskite cubic cell. An excitation of 286.5 nm from Gd3+ and energy transfer to Ce3+ with 405 nm emission are observed, which represents the potential for high‐energy conversion. These experimental results also offer the pathway to tunable optical properties of high‐entropy rare‐earth epitaxial perovskite films for a range of applications.
Ferroelasticity Mediated Energy Conversion in Strained Perovskite Films
Authors: Jiao Yinan , Qin Shengjian , Li Bing , Hao Weizhong , Wang Ye , Li Hao , Yang Zhanping , Dong Dejun , Li Xiangyu , Zhao Jinjin 
Published: August 2022

AbstractMetal halide perovskites (MHPs) have been shown to be key materials for next‐generation photovoltaic energy harvesting, electro‐optic detection, and all‐optical conversion. Room‐temperature tetragonal MAPbI3 has been reported to possess two space groups: polar I4cm and non‐polar I4/mcm. Although the space group of MAPbI3 is still under debate, significant effort has been expended to prove that I4cm MHPs are ferroelectric and I4/mcm MHPs are antiferroelectric. Both structures belong to the ferroelastic point group, and there has been debate regarding whether the domain structures observed on MHPs are ferroelectric or ferroelastic. The relationship between the ferroelectricity and ferroelasticity of MHPs has been discussed, whereas these two properties sometimes are regarded as mutually exclusive in MHPs. In this work, the ferroelectricity and ferroelasticity of MHPs originating from structural symmetry have been reviewed, and the interrelationship between the ferroelectricity and ferroelasticity of MHPs are discussed.
Highly Stretchable, Breathable, and Self‐Powered Strain‐Temperature Dual‐Functional Sensors with Laminated Structure for Health Monitoring, Hyperthermia, and Physiotherapy Applications
Authors: Wen Ningxuan , Fan Zeng , Yang Shuaitao , Guo Yuan , Zhang Jianwei , Lei Bowen , Zhao Yongpeng , Cong Tianze , Li Chengwei , Jing Zhenguo , Pan Lujun 
Published: August 2022

AbstractIn recent years, wearable multifunctional sensors have experienced tremendous development due to their wide application prospects in areas such as Internet of Things, human‐machine interactions, and personal health monitoring. These sensors require not only superior capability to distinguish multiple stimuli with effective signal decoupling, but also good wearable comfortability and even self‐powered features. In this work, a highly stretchable, breathable, and self‐powered sensor enabling simultaneous detection of large tensile strain and temperature stimuli has been designed and successfully fabricated. In this sensor, two functional layers for strain sensing and temperature sensing with high mechanical compatibility are independently arranged, thereby facilitating effective signal decoupling upon the strain‐temperature coupled dual‐stimuli. Notably, this strain‐temperature dual‐functional sensor exhibits not only a high stretchability with a wide working range of up to 100%, but also excellent strain sensing capability and temperature sensing capability. Based on a rational electric circuit design, the sensor further enables synchronous strain‐temperature monitoring in a self‐powered mode. Its practical applications for human motion monitoring, hyperthermia, and physiotherapy are demonstrated. Combining the excellent sensing performance and wearability, the sensor developed in this work can hold great promise for future wearable electronics and E‐skin applications.
Grain‐Slip Derived Network Topology to Remarkable Strength–Toughness Combination of Perovskite Film for Flexible Solar Cells
Authors: Lu Zheng , Lou Yanhui , Xiao Lingbo , Xu Xiaoli , Wang Chen , Li Lutao , Su Xiaodong , Zou Guifu 
Published: August 2022

AbstractThe toughness and strength are generally mutually exclusive for most materials. Although the biological materials in nature such as wood, bone, and nacre exhibit outstanding toughness by forming hierarchical multiscale (nano to macro) structures, it is a huge challenge to simultaneously obtain excellent strength and toughness from material synthesis. Here, one kind of network topology is observed by introducing sodium hyaluronate into organometallic halide perovskite film to greatly improve its strength and toughness. The grain slip and grain subdivision under tensile stress are schemed to dissipate the system energy and endow the perovskite film with remarkable toughness. Meanwhile, the subdivided grains linked by sodium hyaluronate through strong interaction result in high strength of perovskite film. As a result, the perovskite films exhibit robust enhancements with the elongation at break from 1.58% to 5.02% and the fracture strength from 23.13 to 55.25 MPa. It is worth noting that the efficiency of inverted flexible perovskite solar cells reaches 20.01% as well as maintains 90% of the initial efficiency after 6000 cycles of bending at a 2 mm curvature radius. This work devises a topology structure to overcome the conflict between toughness and strength of perovskite films for wearable electronics.
Educator's blueprint: A how‐to guide for creating a high‐quality infographic
Authors: Gottlieb Michael , Ibrahim Andrew M. , Martin Lynsey J. , Yilmaz Yusuf , Chan Teresa M. 
Published: August 2022

AbstractInfographics are a valuable tool for increasing knowledge translation and dissemination. They can be used to simplify complex topics and supplement the written text of a study. This Educator's Blueprint paper will provide 10 strategies for creating high‐quality infographics. These strategies include selecting appropriate content, defining the target audience, considering the format, selecting the software, using consistent font and color schemes, increasing image utilization, ensuring a consistent flow of ideas, avoiding copyright and HIPAA violations, getting feedback from others, and utilizing effective dissemination strategies. These strategies will help guide educators to increase their ability to create more effective infographics.
Bahiagrass and soil responses to lime sources and application levels
Authors: Cardoso Abmael da Silva , Silveira Maria L. , Kohmann Marta M. , Vendramini João M. B. , Sellers Brent , Baldo Amanda , Sekiya Bianca Midori Souza 
Published: August 2022

AbstractThe increasing cost of lime and the agronomic problems associated with soil acidity management has prompted the need to re‐examine management strategies to correct soil pH while maintaining forage productivity. This study evaluated the effect of different lime sources (pelletized dolomitic limestone [dolomite] and hydrated calcitic limestone [Hi‐Cal]) and application levels (0, 1.1, 2.2, and 4.4 Mg ha–1 yr–1) on soil chemical properties and bahiagrass (Paspalum notatum Flügge) responses in 2014 through 2017. Forage and soil responses were monitored during the 4‐yr period, and residual lime effect was also evaluated 3 yr after liming ceased (2020). Liming increased bahiagrass herbage accumulation by 12% relative to control; however, no effect of lime source (P = .6), application level (P = .16), or their interaction (P = .11) was observed. Both lime sources increased tissue P, Mg, Ca, and S concentrations relative to control; however, tissue B, Zn, Mn, Fe, and Cu generally decreased. A single application of Hi‐Cal or two annual applications of dolomite increased soil pH from 4.5 to the recommended level of 5.5 for bahiagrass. Soil pH (0–45 cm depth) increased with repeated lime applications particularly in Hi‐Cal treatments, but no adverse effects on bahiagrass were observed. Soil pH remained above the recommended level 3 yr after liming ceased. Despite the lack of treatment effect, soil P and K levels decreased with time likely because of nutrient removal with harvested forage. Proper P and K fertilization along with soil pH management are key components to maintain long‐term productivity of bahiagrass.
Retrospective comparison of survival and responses to Fludarabine, Cytarabine, GCSF (FLAG) in combination with gemtuzumab ozogamicin (GO) or Idarubicin (IDA) in patients with newly diagnosed core binding factor (CBF) acute myelogenous leukemia: MD Anderson experience in 174 patients
Authors: Borthakur Gautam , Ravandi Farhad , Patel Keyur , Wang Xuemei , Kadia Tapan , DiNardo Courtney , Garcia‐Manero Guillermo , Pemmaraju Naveen , Jabbour Elias J. , Takahashi Koichi , Ohanian Maro , Daver Naval , Alvarado Yesid , Brandt Mark , Pierce Sherry , Kantarjian Hagop 
Published: August 2022

AbstractFludarabine, cytarabine, GCSF (FLAG)‐based induction/consolidation results in high remission rates in core binding factor (CBF) acute myelogenous leukemia. We treated 174 consecutive patients with newly diagnosed CBF‐AML in a prospective clinical trial of FLAG‐based induction/consolidation in combination with gemtuzumab ozogamicin (FLAG‐GO; N = 65) or in combination with idarubicin (FLAG‐IDA; N = 109). The 5 year RFS in the FLAG‐GO cohort was significantly better than the FLAG‐IDA cohort, 78% versus 59%, respectively (p‐value = .02). In multivariate analysis for RFS, age (p = .0001), FLAG‐GO regimen (p = .04), 4 log reduction in CBF‐related fusion transcript by quantitative polymerase chain reaction (qPCR) in bone marrow samples at end of consolidation therapy (p = .03), and additional cytogenetic abnormalities (p = .03) were significant variables. Lower age (p = .0001) and 3 log or more transcript reduction at end of induction (p = .04) were significant variables predicting for better overall survival (OS), while there was strong trend for better OS with FLAG‐GO (p = .06) regimen. FLAG‐GO regimen was superior in optimal disease specific fusion transcript reduction at end of induction (p = .002), mid‐consolidation (p < .01), and end of consolidation (p < .001) therapy. Induction/consolidation with FLAG‐GO regimen results in better clinical outcomes in newly diagnosed patients with CBF‐AML compared to FLAG‐IDA and achieves deeper molecular clearance by qPCR assessment of the fusion transcripts.
Synthesis of 3‐(Phenylcarbonyl)‐1H‐indazole Derivatives through Intramolecular Cyclization under Mild Conditions
Authors: Kuroyanagi Sota , Kikuchi Shumpei , Sumikoshi Shunsuke , Uwano Mizuho , Chiba Takayuki , Yamakado Ryohei , Okada Shuji 
Published: August 2022

AbstractThe synthesis of 3‐(phenylcarbonyl)‐1H‐indazole derivatives via the intramolecular cyclization of triazene derivatives substituted by a 2‐(phenylethynyl)phenyl group at the position 3 was developed. The azonium salt, the key intermediate in the reaction, was prepared under mild conditions from trimethylsilyl iodide (TMSI) obtained from an in situ mixture of trimethylsilyl chloride (TMSCl) and sodium iodide (NaI). The obtained 3‐(phenylcarbonyl)‐1H‐indazole derivatives exhibited interesting optical properties including phosphorescence, which was verified by theoretical calculations.
Using phylogeographic link‐prediction in primates to prioritize human parasite screening
Authors: Werner Courtney S. , Kasan Koray , Geyer Julie K. , Elmasri Mohamad , Farrell Maxwell J. , Nunn Charles L. 
Published: August 2022

AbstractObjectivesThe ongoing risk of emerging infectious disease has renewed calls for understanding the origins of zoonoses and identifying future zoonotic disease threats. Given their close phylogenetic relatedness and geographic overlap with humans, non‐human primates (NHPs) have been the source of many infectious diseases throughout human evolution. NHPs harbor diverse parasites, with some infecting only a single host species while others infect species from multiple families.Materials and MethodsWe applied a novel link‐prediction method to predict undocumented instances of parasite sharing between humans and NHPs. Our model makes predictions based on phylogenetic distances and geographic overlap among NHPs and humans in six countries with high NHP diversity: Columbia, Brazil, Democratic Republic of Congo, Madagascar, China, and Indonesia.ResultsOf the 899 human parasites documented in the Global Infectious Diseases and Epidemiology Network (GIDEON) database for these countries, 12% were shared with at least one other NHP species. The link prediction model identified an additional 54 parasites that are likely to infect humans but were not reported in GIDEON. These parasites were mostly host generalists, yet their phylogenetic host breadth varied substantially.DiscussionAs human activities and populations encroach on NHP habitats, opportunities for parasite sharing between human and NHPs will continue to increase. Our study identifies specific infectious organisms to monitor in countries with high NHP diversity, while the comparative analysis of host generalism, parasite taxonomy, and transmission mode provides insights to types of parasites that represent high zoonotic risk.