bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Kapasitas Manajemen LKSA Guyub Rukun Kota Bengkulu
Authors: Osira Yessilia , Muzni Nurlianti 
Published: February 2022

Development of Management Capacity of LKSA Guyub Rukun Bengkulu City. Capacity building is a process, which is carried out at three levels, namely individuals, groups, and institutions or organizations, in this case, the LKSA Guyub Rukun. This process is carried out to ensure the continuity of the organization through the achievement of the goals and objectives of the organization concerned. In this regard, the community service activities carried out as a form of follow-up to the cooperation agreement between the Faculty of social and Political Sciences, Bengkulu University, and LKSA Guyub Rukun Bengkulu City, have the following objectives: 1) Assist the LKSA Guyub Rukun Management in managing the administration of the institution's activities. 2) Assist the LKSA Guyub Rukun Management in scheduling various children's activities at the institution. 3) Assist the LKSA Guyub Rukun Management in preparing the process of implementing institutional accreditation. The results of service activities are ultimately a form of assistance in the accreditation process carried out by LKSA Guyub Rukun, which includes an assessment of 6 accreditation standards: standard 1 (services to inmates), standard 2 (the process of social worker practice service), standard 3 (organizational management), standard 4 (human resources), standard 5 (facilities and infrastructure, and standard 6 (outcomes of institutional services). Keywords: Capacity building, LKSA management, accreditation
PEMBUATAN BAKSO SEHAT DENGAN PENAMBAHAN BUAH NAGA MERAH BAGI MASYARAKAT DI DESA SRIKATON, KECAMATAN PONDOK KELAPA, BENGKULU TENGAH
Authors: Suharyanto Suharyanto , Soetrisno Edi , Yurike Y 
Published: February 2022

Meatballs are meat-based processed products that are favored by most people. This is very positive because it can be a medium for increasing the consumption of animal protein from meat for the community. However, the popularity of this meatball must be balanced with its availability in a healthy formula for consumers. Problems that occur in Srikaton Village, including 1) The low awareness of the community to produce and consume healthy natural processed products; 2) Public awareness is still low in the consumption of protein derived from meat; 3) In the midst of the Covid-19 pandemic, the people of Srikaton Village need to increase their family business to increase family income. Based on the problems above, the solution offered is to provide training for making healthy meatballs with the addition of red dragon fruit. The purpose of this activity is to introduce the benefits of the importance of consuming animal protein and to utilize red dragon fruit in making meatballs to increase antioxidants, become very attractive preservatives and natural dyes. Besides that, it can also increase people's income because basically it can be done with a home industry scale and become a business for people who live in rural areas. Activities are carried out using the method of material presentation, discussion and practice. The result of this community service is increasing public awareness in producing and consuming healthy natural processed products and the creation of meatball products with a nutritious mixture of dragon fruit. There is a need for the sustainability of this activity, especially the existence of innovation training or diversification of other food products. Keywords: Healthy meatballs; Red dragon fruit; Diversification; Innovation
PENDIDIKAN AGAMA ISLAM BAGI ANAK PADA KELUARGA PEKERJA DI DESA WAEYASEL KABUPATEN MALUKU TENGAH
Authors: Waly Astriani 
Published: February 2022

Abstract: This study aims to determine Islamic religious education for children in working families in Waeyasel village, Central Maluku district. The questions to be answered through this research are: 1) how is Islamic religious education for the children of fishermen, farmers and teachers in Waeyasel Village. 2) how to implement Islamic religious education for children in Waeyasel village. 3) what are the inhibiting and supporting factors of Islamic religious education for children in working families in Waeyasel Village. The method used in this research is qualitative method. Data collection techniques in the form of observation, interviews and documentation. as well as data analysis techniques in the form of stages, data reduction, and data presentation and draw conclusions the research was carried out for one month. Based on the results of the study that there are three educations applied by working parents: first, worship education, parents teach how to worship, both mandatory worship and sunnah worship. such as prayer, fasting, reading and the Qur'an, secondly, parental moral education teaches their children how to eat well, make friends, be polite to parents and respect elders, thirdly, aqidah education instills confidence and faith that God exists. and always see and supervise him in every action he does, what parents teach to their children makes the child accustomed to doing the things his parents taught him. Keywords: Islamic religious education, children, families, workers Abstrak: Penelitian ini bertujuan untuk mengetahui pendidikan agama Islam bagi anak pada keluarga pekerja di desa waeyasel kabupaten Maluku tengah. Pertanyaan yang ingin dijawab melalui penelitian ini adalah: 1) bagaimana pendidikan agama Islam bagi anak nelayan, petani dan guru di Desa waeyasel. 2) bagaimana implementasi pendidikan agama Islam bagi anak di desa waeyasel. 3) apa saja faktor-faktor penghambat dan pendukung pendidikan agama islam bagi anak pada keluarga pekerja di Desa waeyasel. Metode yang digunakan dalam penelitian ini adalah metode kualitatif. Teknik pengumpulan data berupa observasi, wawancara dan dokumentasi. serta teknik analisis data berupa tahap , reduksi data, dan penyajian data dan menarik kesimpulan penelitian dilaksanakan selama satu bulan. Berdasarkan hasil penelitian bahwa ada tiga pendidikan yang diterapkan orang tua pekerja: pertama pendidikan ibadah, orangtua mengajarkan bagaimana cara ibadah, baik ibadah wajib maupun ibadah sunnah. seperti shalat, puasa, membaca dan Al Qur’an, kedua, pendidikan akhlak orangtua mengajarkan kepada anaknya bagaimana adab makan yang baik, adab berteman, sopan santun pada orangtua dan menghormati yang lebih tua,ketiga pendidikan aqidah menanamkan keyakinan dan keimanan bahwa Allah itu ada dan selalu melihat serta mengawasinya dalam setiap perbuatan yang ia lakukan, apa yang diajarkan orangtua kepada anaknya membuat anak tersebut terbiasa melakukan hal-hal yang diajarkan orangtuanya. Kata kunci: pendidikan agama islam, anak, keluarga, pekerja.
Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications
Authors: Nicksic Peter J. , Donnelly D’Andrea T. , Hesse Madison , Bedi Simran , Verma Nishant , Seitz Allison J. , Shoffstall Andrew J. , Ludwig Kip A. , Dingle Aaron M. , Poore Samuel O. 
Published: February 2022

Since the piezoelectric quality of bone was discovered in 1957, scientists have applied exogenous electrical stimulation for the purpose of healing. Despite the efforts made over the past 60 years, electronic bone growth stimulators are not in common clinical use. Reasons for this include high cost and lack of faith in the efficacy of bone growth stimulators on behalf of clinicians. The purpose of this narrative review is to examine the preclinical body of literature supporting electrical stimulation and its effect on bone properties and elucidate gaps in clinical translation with an emphasis on device specifications and mechanisms of action. When examining these studies, trends become apparent. In vitro and small animal studies are successful in inducing osteogenesis with all electrical stimulation modalities: direct current, pulsed electromagnetic field, and capacitive coupling. However, large animal studies are largely unsuccessful with the non-invasive modalities. This may be due to issues of scale and thickness of tissue planes with varying levels of resistivity, not present in small animal models. Additionally, it is difficult to draw conclusions from studies due to the varying units of stimulation strength and stimulation protocols and incomplete device specification reporting. To better understand the disconnect between the large and small animal model, the authors recommend increasing scientific rigor for these studies and reporting a novel minimum set of parameters depending on the stimulation modality.
Antifungal Activity and Biocompatibility of α-AgVO3, α-Ag2WO4, and β-Ag2MoO4 Using a Three-Dimensional Coculture Model of the Oral Mucosa
Authors: Pimentel Bruna Natália Alves da Silva , Marin-Dett Freddy Humberto , Assis Marcelo , Barbugli Paula Aboud , Longo Elson , Vergani Carlos Eduardo 
Published: February 2022

Fungal infections have become a major concern in the medical community, especially those caused by Candida spp. Within this species, Candida albicans stands out for being an opportunistic commensal fungus that can cause superficial and invasive infections. Current antifungal therapy involves the local and/or systemic use of drugs such as azoles, polyenes, and echinocandins. These antifungals are based on highly specific target sites, and the development of resistance may occur with changes in the enzymatic pathways that serve as the drug targets. Thus, the development of new antifungal drugs is highly recommended to prevent drug resistance. The present investigation evaluated the antifungal activity of silver-containing microcrystals such as silver vanadate (α-AgVO3), silver tungstate (α-Ag2WO4), and silver molybdate (β-Ag2MoO4). In addition to having antimicrobial activity, such compounds should not cause damage to underlying tissues. Thus, to better assess the biocompatibility of new compounds, a new three-dimensional (3D) coculture model involving three cell lines was developed. The validation of the model was based on fluorescent markers and confocal laser microscopy. The biocompatibility of silver-containing microcrystals was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. 3D coculture was infected with C. albicans biofilm and challenged with α-AgVO3, α-Ag2WO4, and β-Ag2MoO4. The action of microcrystals on C. albicans biofilm was evaluated by colony-forming units (CFU/ml) and LIVE/DEAD staining. In addition, production of proinflammatory cytokines interleukin 6 (IL-6), IL-8, IL-1β, and tumor necrosis factor α (TNF-α) was measured by cytometric bead array kit using flow cytometry. The 3D coculture model described here proved to be adequate to assess both the biocompatibility of the new materials and the infectious processes. Regarding the biocompatibility of the microcrystals, only α-AgVO3 (15.62 µg/ml) showed a decrease in cell viability. The antibiofilm activity of α-Ag2WO4 was similar to that of the standard drug (fluconazole). Although α-Ag2WO4 was able to induce the production of IL-6, IL-8, and IL-1β, no differences in cytokine production were observed between noninfected and infected models treated with this microcrystal. β-Ag2MoO4 inhibits the production of TNF-α in the infected model; however, it showed no antibiofilm activity. Based on the biocompatibility and antifungal findings, α-Ag2WO4 is a promising material for treating C. albicans infection.
Nivolumab-DTPA-Based PD-1 Imaging Reveals Structural and Pathological Changes in Colorectal Carcinoma
Authors: Li Danni , Li Xiao , Yang Jian , Shi Zhang , Zhang Lu , Li Rou , Peng Ye , Liu Jiajun , Zuo Changjing 
Published: February 2022

Programmed cell death protein 1 (PD-1) expression is considered a prognostic marker of tumor response to the immuno-blocking therapy. In this study, nivolumab was conjugated with diethylenetriamine pentaacetate (DTPA) via condensation reaction between amidogen and p-SCN-Bn-DTPA, which provided labeling sites for 99mTc4+ or Gd3+ ions. SPECT and magnetic resonance T1 weighted imaging (T1WI) analyses were performed on mouse models of colorectal carcinoma expressing humanized PD-1 antigen. Furthermore, PD-1 expression in intestinal tracks was assessed by immunohistochemistry, and then compared with the imageological findings. Nivolumab-DTPA was synthesized with varying molar ratios and was labeled with Gd or 99mTc with a chemical purity of 96.28 ± 1.16% and good stability. In SPECT images, lesions with high 99mTc-DTPA-nivolumab uptake and relatively clear background were shown at 6 h. Thereafter, the suspected intestinal thickening in Gd-free T1WI was observed at 2 h after the addition of Gd-DTPA-nivolumab. Notably, the results of both SPECT and T1WI analyses were consistent with the postmortem examination and immunohistochemistry results (for linear correlation with target to non-target ratios, R2 = 0.8038, p &lt; 0.05). In conclusion, nivolumab-DTPA could act as a probe precursor for identifying PD-1-positive lesions, not only through integrating the advantages of immunohistochemistry and molecular imaging but also by providing a noninvasive method for monitoring systemic changes.
Fabrication and Characterization of the Porous Ti4O7 Reactive Electrochemical Membrane
Authors: Qi Guangfeng , Wang Xiaohui , Zhao Jingang , Song Chunyan , Zhang Yanbo , Ren Feizhou , Zhang Nan 
Published: February 2022

Preparation of the Magnéli Ti4O7 reactive electrochemical membrane (REM) with high purity is of great significance for its application in electrochemical advanced oxidation processes (EAOPs) for wastewater treatment. In this study, the Ti4O7 REM with high purity was synthesized by mechanical pressing of TiO2 powders followed by thermal reduction to Ti4O7 using the Ti powder as the reducing reagent, where the TiO2 monolith and Ti powder were separated from each other with the distance of about 5 cm in the vacuum furnace. When the temperature was elevated to 1333 K, the Magnéli phase Ti4O7 REM with the Ti4O7 content of 98.5% was obtained after thermal reduction for 4 h. Noticeably, the surface and interior of the obtained REM bulk sample has a homogeneous Ti4O7 content. Doping carbon black (0wt%-15wt%) could increase the porosity of the Ti4O7 REM (38–59%). Accordingly, the internal resistance of the electrode and electrolyte and the charge-transfer impedance increased slightly with the increasing carbon black content. The optimum electroactive surface area (1.1 m2) was obtained at a carbon black content of 5wt%, which increased by 1.3-fold in comparison with that without carbon black. The as-prepared Ti4O7 REMs show high oxygen evolution potential, approximately 2.7 V/SHE, indicating their appreciable electrocatalytic activity toward the production of •OH.
Percutaneous Coronary Intervention in Patients With Gynecological Cancer: Machine Learning-Augmented Propensity Score Mortality and Cost Analysis for 383,760 Patients
Authors: Thomason Nicole , Monlezun Dominique J. , Javaid Awad , Filipescu Alexandru , Koutroumpakis Efstratios , Shobayo Fisayomi , Kim Peter , Lopez-Mattei Juan , Cilingiroglu Mehmet , Iliescu Gloria , Marmagkiolis Kostas , Ramirez Pedro T. , Iliescu Cezar 
Published: February 2022

BackgroundDespite the growing number of patients with both coronary artery disease and gynecological cancer, there are no nationally representative studies of mortality and cost effectiveness for percutaneous coronary interventions (PCI) and this cancer type.MethodsBackward propagation neural network machine learning supported and propensity score adjusted multivariable regression was conducted for the above outcomes in this case-control study of the 2016 National Inpatient Sample (NIS), the United States' largest all-payer hospitalized dataset. Regression models were fully adjusted for age, race, income, geographic region, cancer metastases, mortality risk, and the likelihood of undergoing PCI (and also with length of stay [LOS] for cost). Analyses were also adjusted for the complex survey design to produce nationally representative estimates. Centers for Disease Control and Prevention (CDC)-based cost effectiveness ratio (CER) analysis was performed.ResultsOf the 30,195,722 hospitalized patients meeting criteria, 1.27% had gynecological cancer of whom 0.02% underwent PCI including 0.04% with metastases. In propensity score adjusted regression among all patients, the interaction of PCI and gynecological cancer (vs. not having PCI) significantly reduced mortality (OR 0.53, 95%CI 0.36–0.77; p = 0.001) while increasing LOS (Beta 1.16 days, 95%CI 0.57–1.75; p &lt; 0.001) and total cost (Beta $31,035.46, 95%CI 26758.86–35312.06; p &lt; 0.001). Among gynecological cancer patients, mortality was significantly reduced by PCI (OR 0.58, 95%CI 0.39–0.85; p = 0.006) and being in East North Central, West North Central, South Atlantic, and Mountain regions (all p &lt; 0.03) compared to New England. PCI reduced mortality but not significantly for metastatic patients (OR 0.74, 95%CI 0.32–1.71; p = 0.481). Eighteen extra gynecological cancer patients' lives were saved with PCI for a net national cost of $3.18 billion and a CER of $176.50 million per averted death.ConclusionThis large propensity score analysis suggests that PCI may cost inefficiently reduce mortality for gynecological cancer patients, amid income and geographic disparities in outcomes.
Clinical Results and Aortic Remodeling After Endovascular Treatment for Complicated Type B Aortic Dissection With the “Fabulous” Stent System
Authors: Wang Ruihan , Kan Yuanqing , Yang Mou , Zhang Hongkun , Zhang Xiaoming , Dai Xiangchen , Zhai Shuiting , Hu Hejie , Zhang Xiwei , Chen Bing , Huang Jianhua , Qin Xiao , Xiao Zhanxiang , Lu Xinwu , Guo Wei , Si Yi , Fu Weiguo 
Published: February 2022

ObjectiveTo report the clinical outcomes and aortic remodeling after the implantation of a self-developed, biomechanically optimized, two-stage thoracic stent system named Fabulous.BackgroundGiven the efficacy of the PETTICOAT concept, the benefits of Fabulous and the behavior of remodeling in different segments need further investigation.MethodsThis is a prospective and multicenter study. From 2017 to 2019, 145 patients (mean age, 56.6 years; 88.3% male) from 14 centers were included in this cohort. The clinical results and core laboratory results were from a central electronic data capture system. Computed tomographic angiography was performed preoperatively, 1 month, 6 months and yearly thereafter and was used for volumetric analysis by 3mensio (Bilthoven, The Netherlands). After the 1-year follow-up, 97.2 and 87.6% of the clinical and imaging results of the eligible patients were available.ResultsBoth stent grafts and bare stents were successfully delivered in place in 100% of the patients. The 30-day mortality and 1-year freedom from all-cause mortality were 2.1 and 96.6%, respectively. The incidence of entry flow was 11.7% at 30 days and 6.2% at 365 days. No cases of stent-induced new entry (SINE) or reintervention were observed. After the 1-year follow-up, the true lumen/overall volume ratio reached 88%. The following subdivided segment volume changes were recorded: stent graft segment TL +56%; FL −92%, bare stent segment TL +32%; FL −75%, and there were no significant changes in the visceral segment.ConclusionsThese outcomes indicated that there were favorable clinical benefits of Fabulous stent system. This device achieved a low short-term mortality and a low incidence of reintervention. In addition, patients undergoing Fabulous stent system implantation showed remodeling both on descending aorta and on the distal aorta. The volume changes in the TL and FL varied in the different segments. The long-term follow-up is still ongoing.
Early Quaternary Tectonic Transformation of the Helan Shan: Constraints Due To Quantitative Geomorphology
Authors: Li Yige , Zheng Wenjun , Yang Jingjun , Zhang Dongli , Zhou Haoyu , Liu Ting 
Published: February 2022

The Helan Shan is located on the front edge of the expanding Tibetan Plateau. However, how the topography here responds to this propagation and its precise time constraints remain unknown. Based on the response process of fluvial landforms and tectonic evolution, we conducted a quantitative landform analysis of the Helan Shan region. Here, the spatial distribution features of various geomorphic indices were coupled, demonstrating that the mountain is tilting toward the west and north. The steeper downstream and gentle upper reaches indicate that the fluvial landforms have experienced an accelerated incision event, which can be attributed to the tectonic activity along the East Helan Shan Fault. Furthermore, the response time of the tectonic knickpoints ranges from 0.1 to 1.4 Ma based on the paleochannel reconstruction method. Combined with previous studies on low temperature thermochronology and active tectonics, we proposed a tectonic transformation model where the Helan Shan shifted the tilting model from the southwest to the northwest, as induced by the northeast expansion of the Tibetan Plateau from 0.1 to 1.4 Ma.
Spatiotemporal Characteristics of NPP Changes in Frozen Ground Areas of the Three-River Headwaters Region, China: A Regional Modeling Perspective
Authors: Hu Jianan , Nan Zhuotong , Ji Hailong 
Published: February 2022

Permafrost degradation triggered by climate warming can disturb alpine ecosystem stability and further influence net primary productivity (NPP). Known as the “water tower of China”, the Three-River Headwaters Region (TRHR) on the eastern Qinghai-Tibet plateau (QTP), is characterized by a fragile alpine meadow ecosystem underlain by large areas of unstable permafrost and has been subject to rapid climate change in recent decades. Despite some site-specific studies, the spatial and temporal changes in NPP in the different frozen ground zones across the TRHR associated with climate change remain poorly understood. In this study, a physically explicit Noah land surface model with multi-parameterization options (Noah-MP) was employed to simulate NPP changes on the TRHR during 1989–2018. The simulation was performed with a spatial resolution of 0.1° and a temporal resolution of 3h, and validated at two sites with meteorological and flux observations. The results show that the average NPP was estimated to be 299.7 g C m−2 yr−1 in the seasonally frozen ground (SFG) zone and 198.5 g C m−2 yr−1 in the permafrost zone. NPP in the TRHR increased at a rate of 1.09 g C m−2 yr−2 during 1989–2018, increasing in 1989–2003 and then decreasing in subsequent years. The NPP in permafrost area increased at a rate of 1.43 g C m−2 yr−2 during 1989–2018, which is much higher than the rate of change in NPP in the SFG area (0.67 g C m−2 yr−2). Permafrost degradation has complicated ecosystem implications. In areas where permafrost degradation has occurred, both increasing and decreasing changes in NPP have been observed.
Entropy Analysis of a Valveless Piezoelectric Pump With Hyperbolic Tubes
Authors: Yang Qing , Chen Jun 
Published: February 2022

In order to solve the problems of large reflux and low output performance of the valveless piezoelectric pump with conical tubes, the valveless piezoelectric pump with hyperbolic tubes was proposed. However, the previous research only paid attention to the difference of forward and reverse flow resistance inside the tubes. For this reason, the prototypes of conical tube valveless piezoelectric pump and hyperbolic tubes valveless piezoelectric pump were fabricated in this paper. The maximum output flow rate of the valveless piezoelectric pump with hyperbolic tubes was 54 ml/min. Subsequently, the size and position of entropy production of the hyperbolic tube and the conical tube were numerically calculated based on entropy production theory in this paper. The results show that the entropy production rate of the hyperbolic tube was significantly lower than that of the conical tube, which is consistent with the experimental results. This research analyzed the energy loss inside the valveless piezoelectric pump by using the entropy generation theory, and provided a new design and research method for improving the output performance of the valveless piezoelectric pump in the future.