bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network pharmacology combined with GEO database identifying the mechanisms and molecular targets of Polygoni Cuspidati Rhizoma on Peri-implants
Authors: Shan Chao , Ji Xiaowei , Wu Zeyu , Zhao Jin 
Published: May 2022

AbstractPeri-implants is a chronic disease leads to the bone resorption and loss of implants. Polygoni Cuspidati Rhizoma (PCRER), a traditional Chinese herbal has been used to treat diseases of bone metabolism. However, its mechanism of anti-bone absorption still remains unknown. We aimed to identify its molecular target and the mechanism involved in PCRER potential treatment theory to Peri-implants by network pharmacology. The active ingredients of PCRER and potential disease-related targets were retrieved from TCMSP, Swiss Target Prediction, SEA databases and then combined with the Peri-implants disease differential genes obtained in the GEO microarray database. The crossed genes were used to protein–protein interaction (PPI) construction and Gene Ontology (GO) and KEGG enrichment analysis. Using STRING database and Cytoscape plug-in to build protein interaction network and screen the hub genes and verified through molecular docking by AutoDock vina software. A total of 13 active compounds and 90 cross targets of PCRER were selected for analysis. The GO and KEGG enrichment analysis indicated that the anti-Peri-implants targets of PCRER mainly play a role in the response in IL-17 signaling, Calcium signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway among others. And CytoHubba screened ten hub genes (MMP9, IL6, MPO, IL1B, SELL, IFNG, CXCL8, CXCL2, PTPRC, PECAM1). Finally, the molecular docking results indicated the good binding ability with active compounds and hub genes. PCRER’s core components are expected to be effective drugs to treat Peri-implants by anti-inflammation, promotes bone metabolism. Our study provides new thoughts into the development of natural medicine for the prevention and treatment of Peri-implants.
Regulation and function of elF2B in neurological and metabolic disorders
Authors: Hanson Filipe M. , Hodgson Rachel E. , de Oliveira Madalena I. Ribeiro , Allen K. Elizabeth , Campbell Susan Gerarda 
Published: May 2022

Abstract
Eukaryotic initiation factor 2B, eIF2B is a guanine nucleotide exchange, factor with a central role in coordinating the initiation of translation. During stress and disease, the activity of eIF2B is inhibited via the phosphorylation of its substrate eIF2 (p-eIF2α). A number of different kinases respond to various stresses leading to the phosphorylation of the alpha subunit of eIF2, and collectively this regulation is known as the integrated stress response, ISR. This targeting of eIF2B allows the cell to regulate protein synthesis and reprogramme gene expression to restore homeostasis. Advances within structural biology have furthered our understanding of how eIF2B interacts with eIF2 in both the productive GEF active form and the non-productive eIF2α phosphorylated form. Here, current knowledge of the role of eIF2B in the ISR is discussed within the context of normal and disease states focusing particularly on diseases such as vanishing white matter disease (VWMD) and permanent neonatal diabetes mellitus (PNDM), which are directly linked to mutations in eIF2B. The role of eIF2B in synaptic plasticity and memory formation is also discussed. In addition, the cellular localisation of eIF2B is reviewed and considered along with the role of additional in vivo eIF2B binding factors and protein modifications that may play a role in modulating eIF2B activity during health and disease.
In-depth direct imaging and spectroscopic characterization of the young Solar System analog HD 95086
Authors: Desgrange C. , Chauvin G. , Christiaens V. , Cantalloube F. , Lefranc L.-X. , Le Coroller H. , Rubini P. , Otten G. P. P. L. , Beust H. , Bonavita M. , Delorme P. , Devinat M. , Gratton R. , Lagrange A.-M. , Langlois M. , Mesa D. , Milli J. , Szulágyi J. , Nowak M. , Rodet L. , Rojo P. , Petrus S. , Janson M. , Henning T. , Kral Q. , van Holstein R. G. , Ménard F. , Beuzit J.-L. , Biller B. , Boccaletti A. , Bonnefoy M. , Brown S. , Costille A. , Delboulbe A. , Desidera S. , D’Orazi V. , Feldt M. , Fusco T. , Galicher R. , Hagelberg J. , Lazzoni C. , Ligi R. , Maire A.-L. , Messina S. , Meyer M. , Potier A. , Ramos J. , Rouan D. , Schmidt T. , Vigan A. , Zurlo A. 
Published: May 2022

Context.HD 95086 is a young nearby Solar System analog hosting a giant exoplanet orbiting at 57 au from the star between an inner and outer debris belt. The existence of additional planets has been suggested as the mechanism that maintains the broad cavity between the two belts.Aims.We present a dedicated monitoring of HD 95086 with the VLT/SPHERE instrument to refine the orbital and atmospheric properties of HD 95086 b, and to search for additional planets in this system.Methods.SPHERE observations, spread over ten epochs from 2015 to 2019 and including five new datasets, were used. Combined with archival observations, from VLT/NaCo (2012-2013) and Gemini/GPI (2013-2016), the extended set of astrometric measurements allowed us to refine the orbital properties of HD 95086 b. We also investigated the spectral properties and the presence of a circumplanetary disk around HD 95086 b by using the special fitting tool exploring the diversity of several atmospheric models. In addition, we improved our detection limits in order to search for a putative planet c via the K-Stacker algorithm.Results.We extracted for the first time the JH low-resolution spectrum of HD 95086 b by stacking the six best epochs, and confirm its very red spectral energy distribution. Combined with additional datasets from GPI and NaCo, our analysis indicates that this very red color can be explained by the presence of a circumplanetary disk around planet b, with a range of high-temperature solutions (1400–1600 K) and significant extinction (Av≳ 10 mag), or by a super-solar metallicity atmosphere with lower temperatures (800–300 K), and small to medium amount of extinction (Av≲ 10 mag). We do not find any robust candidates for planet c, but give updated constraints on its potential mass and location.
Implantatspezifische Komplikationen aufgrund von Implantatfehllage –
Ursachen, Vermeidungs- und Behandlungskonzepte
Authors: Ryang Yu-Mi 
Published: May 2022

ZusammenfassungDie häufigste implantatspezifische Komplikation ist die Pedikelschraubenfehllage
thorakolumbal. Fehllagen als auch andere Komplikationen scheinen nach aktueller
Datenlage jedoch eher selten geworden zu sein. Insbesondere schwere
neurovaskuläre Komplikationen als auch die Notwendigkeit einer
Schrauben-bedingten Revisions-Operation sind insgesamt gering. Es zeigt sich,
dass der Einsatz moderner Techniken, insbesondere der spinalen Navigation zu
einer Verbesserung der Genauigkeit, Sicherheit, Effektivität und
Revisionsnotwendigkeit beiträgt. Die besten Ergebnisse scheint dabei die
CT-Navigation zu erzielen. Neben der spinalen Navigation sind weitere nützliche
technische Innovationen hinzugekommen, wie elektronische Konduktivitäts-Devices
und patienten-spezifische 3D-gedruckte Führungsschablonen, die die Genauigkeit
und Sicherheit bei spinaler Instrumentation ebenfalls verbessern können. Diese
Arbeit gibt einen Überblick über die aktuelle Datenlage und neue innovative
Techniken, die zu einer Verbesserung Implantat-spezifischer Komplikationen,
insbesondere Schraubenfehllagen beitragen können und gibt praktische Tipps zur
Verbesserung navigierter Eingriffe.
Descemet-Stripping ohne Transplantat bei Fuchsʼscher endothelialer Hornhautdystrophie?
Authors: Menzel-Severing Johannes , Geerling Gerd 
Published: May 2022

ZusammenfassungTraditionell wird das Hornhautendothel als postmitotisch angesehen, sodass von einer spontanen Regeneration nach Verlust von Endothelzellen (z. B. im Rahmen der Fuchsʼschen endothelialen
Hornhautdystrophie) nicht ausgegangen wird. Dennoch konnte in mehreren Fällen beobachtet werden, dass eine ödematöse Hornhaut nach Entfernung eines kleineren Areals der Descemet-Membran
aufklart. Der posteriore Aspekt dieses Bereichs wurde von Hornhautendothelzellen wieder bedeckt. Hieraus entstand ein operatives Therapiekonzept ohne posteriores lamelläres Transplantat:
„Descemet stripping only“. Zugleich legen Daten aus In-vitro-Versuchen nahe, dass Rho-Kinase-Inhibitoren (ROCK-Inhibitoren) pharmakologische Wirkstoffe sind, die eine Proliferation und
Migration des Hornhautendothels fördern und somit den Heilungsverlauf nach Descemet-Stripping positiv beeinflussen. Mittlerweile liegen erste Daten aus kleineren prospektiven, kontrollierten
klinischen Studien vor, die durchweg gute Ergebnisse nach Descemet-Stripping und ROCK-Inhibitor-Augentropfen berichten. Offene Fragen bestehen jedoch derzeit noch hinsichtlich der
Charakteristika der Patientengruppe, die von diesem Therapieansatz besonders profitiert und hinsichtlich der Nachhaltigkeit eines Therapieerfolgs.
Das europäische Netzwerk INNODIA
Authors: Bode Karsten , Reschke Felix , Weiskorn Jantje , Pisarek Nicole , Polier Mareike Polier , Landsberg Sarah , Kordonouri Olga , Danne Thomas 
Published: May 2022

ZUSAMMENFASSUNGHinter dem typischen klinischen Erscheinungsbild des Typ-1-Diabetes (T1D) können sich sehr unterschiedliche Krankheitsverläufe verbergen. Bei vielen Menschen ist zum Zeitpunkt der Manifestation noch eine nicht unerhebliche Restfunktion der Betazellen nachweisbar. In Europa hat sich, finanziert durch die Projekte INNODIA und INNODIA HARVEST der europäischen „Innovative Medicines Initiative“, ein neues Netzwerk zur T1D-Forschung gebildet. Es besteht einerseits aus Grundlagenforschern zur Entdeckung neuartiger Biomarker und Therapien. Anderseits sind darin akkreditierte klinische Zentren mit höchsten Qualitätsstandards organisiert. Das Konsortium führt gegenwärtig 4 klinische Studien an Menschen mit neu diagnostiziertem T1D durch. In Zusammenarbeit mit der Regulationsbehörde EMA entwickelte INNODIA ein einheitliches Studienprotokoll („Masterprotokoll“), um ab dem Alter von 5 Jahren die Untersuchung neuer Einzelsubstanzen und Kombinationstherapien zu beschleunigen.
Typ-1-Diabetes Risikoscreening bei Neugeborenen und Studien zur Prävention des Typ-1-Diabetes
Authors: Kordonouri Olga 
Published: May 2022

ZUSAMMENFASSUNGTyp-1-Diabetes ist eine chronische Autoimmunerkrankung und Ergebnis eines komplexen Zusammenspiels zwischen Umweltfaktoren und Mikrobiom, Genom, Stoffwechsel und Immunsystem, das von Fall zu Fall unterschiedlich ist. Der Beginn des Autoimmunprozesses findet in der Regel Jahre vor der Manifestation der klinischen Symptome statt. Bereits kurz nach der Geburt kann anhand der Bestimmung eines genetischen Scores das Risiko für die Entwicklung des Autoimmunprozesses in der frühen Kindheit ermittelt werden. In dieser Arbeit werden Screeningstrategien zur Typ-1-Diabetes-Risiko-Ermittlung bei Neugeborenen und aktuelle Studien zur Primärprävention der Erkrankung vorgestellt und diskutiert.
Effects of an island-wide rodent eradication programme on two threatened bird species
Authors: Segal Richard D. , Whitsed Rachel , Carlile Nicholas , Massaro Melanie 
Published: May 2022

Context For the past 50 years, rodent eradications have been conducted worldwide to reverse the devastating impacts of introduced rodents on island species. However, few studies have quantitatively measured the effects of rodent eradications on native species. Aims This study investigated the effects of a rodent eradication on Lord Howe Island on two native birds. Methods To mitigate the risk of Lord Howe currawongs being poisoned during baiting operations, 30–40% of the population were taken into captivity during baiting, while the remaining currawongs were left in the wild. We studied currawong survival, nesting density and breeding success pre- and post-eradication to test how the baiting, a period in captivity, and the removal of rodents affected currawongs. We also investigated breeding success of white terns as they were expected to benefit from the eradication due to predator reduction. Key results We found that many currawongs left in the wild disappeared during the baiting period and nesting densities in one part of the island were significantly lower after the eradication. These currawongs likely died of poisoning as they were not resighted for 2 years post-eradication. White tern breeding success did not increase after the rodent eradication, although their predators were largely eliminated. Conclusions The captive management of currawongs mitigated the adverse effects of the baiting. As those currawongs that survived had high breeding success, we predict that the population will soon recover to pre-eradication size. Implications Our study reinforces the necessity of integrating ecological monitoring as part of future eradications on islands.
Analysis of changes in the proteomic profile of porcine corpus luteum during different stages of the oestrous cycle: effects of PPAR gamma ligands
Authors: Kunicka Zuzanna , Mierzejewski Karol , Kurzyńska Aleksandra , Stryiński Robert , Mateos Jesús , Carrera Mónica , Golubska Monika , Bogacka Iwona 
Published: May 2022

Context The corpus luteum (CL) is an endocrine gland in the ovary of mature females during the oestrous cycle and pregnancy. There is evidence of a relationship between the secretory function of the CL and PPARs. Aims In this study, we investigated the changes in the proteome of the CL in relation to the phase of the oestrous cycle and the impact of PPARγ ligands on the proteomic profile of the CL during the mid- and late-luteal phase of the oestrous cycle. Methods The porcine CL explants were incubated in vitro for 6 h in the presence of PPARγ ligands (agonist pioglitazone, antagonist T0070907) or without ligands. Global proteomic analysis was performed using the TMT-based LC-MS/MS method. Key results The obtained results showed the disparity in proteomic profile of the untreated CL – different abundance of 23 and 28 proteins for the mid- and late-luteal phase, respectively. Moreover, seven proteins were differentially regulated in the CL tissue treated with PPARγ ligands. In the mid-luteal phase, one protein, CAND1, was downregulated after treatment with T0070907. In the late-luteal phase, the proteins SPTAN1, GOLGB1, TP53BP1, MATR3, RRBP1 and SRRT were upregulated by pioglitazone. Conclusions Comparative proteomic analysis revealed that certain proteins constitute a specific proteomic signature for each examined phase. Moreover, the study showed that the effect of PPARγ ligands on the CL proteome was rather limited. Implications The results provide a broader insight into the processes that may be responsible for the structural luteolysis of the porcine CL, in addition to apoptosis and autophagy.
La construcción temporal
Authors: Gisbert José Manuel Bustos 
Published: May 2022

AbstractaEste artículo analiza el uso del pretérito perfecto compuesto y el pretérito perfecto simple en los textos expositivos escritos en español y dotados o no de dimensión argumentativa. En primer lugar, se estudia su función en la organización de los textos; se evalúa su presencia en los párrafos iniciales, en los enunciados iniciales de párrafo y en los enunciados iniciales de texto. Asimismo, se analiza su función en la construcción de referencias intertextuales y cotextuales. En segundo lugar, se describe su función en la configuración de dos tipos de informaciones relevante en el discurso expositivo, como son los acontecimientos de partida y las premisas y los saberes conocidos. El trabajo demuestra que el pretérito perfecto compuesto es la herramienta más útil en la expresión de estos dos tipos de información debido a razones, no de naturaleza temporal, sino de estrategia discursiva.
A meshless method to compute pressure fields from image velocimetry
Authors: Sperotto Pietro , Pieraccini Sandra , Mendez Miguel A 
Published: May 2022

AbstractWe propose a meshless method to compute pressure fields from image velocimetry data, regardless of whether this is available on a regular grid as in cross-correlation based velocimetry or on scattered points as in tracking velocimetry. The proposed approach is based on radial basis functions (RBFs) regression and relies on the solution of two constrained least square problems. The first one is the regression of the measurements to create an analytic representation of the velocity field. This regression can be constrained to impose boundary conditions (e.g. no-slip velocity on a wall or inlet conditions) or differential constraints (e.g. the solenoidal condition for an incompressible flow). The second one is the meshless integration of the pressure Poisson equation, achieved by seeking a solution in the form of a RBF expansion and using constraints to impose boundary conditions. We first illustrate the derivation of the two least square problems and the numerical techniques implemented for their solution. Then, we showcase the method with three numerical test cases of growing complexity. These are a 2D Gaussian Vortex, a 2D flow past a cylinder from CFD and a 3D Stokes flow past a sphere. For each case, we consider randomly sampled vector fields simulating particle tracking measurements and analyze the sensitivity to noise and seeding density.
Optical properties of copper helical nanostructures: the effect of thickness on the SPR peak position
Authors: Potočnik J , Božinović N , Novaković M , Barudžija T , Nenadović M , Popović M 
Published: May 2022

Abstract
In this study, we have investigated the effect of thickness on the structural and optical properties of copper (Cu) helical nanostructures. Thin films with thicknesses of 160 nm, 280 nm, 450 nm, and 780 nm were obtained by e-beam glancing angle deposition. The morphology and the microstructure were studied by field emission scanning electron microscopy, x-ray diffraction and transmission electron microscopy, while for the optical analysis measurements spectroscopic ellipsometry was used. The results show that the deposited structures are porous with nanometer-sized crystallites preferentially oriented along (111) planes, as well as that the diameter of the helices increases with thickness. Detailed analyses of optical properties have demonstrated that the dielectric function of Cu structures is greatly influenced by the films thicknesses. With increasing thickness from 160 nm to 780 nm, the surface plasmon resonance peak was shifted from 1.31 eV to 1.05 eV, which was correlated with the growth mechanism and the size of deposited nanostructures.
Adsorption-enhanced photocatalytic property of Ag-doped biochar/g-C3N4/TiO2 composite by incorporating cotton-based biochar
Authors: Kuan Junling , Zhang Hui , Gu Haoshuai , Zhang Yaning , Wu Hailiang , Mao Ningtao 
Published: May 2022

Abstract
In this study, the biochar obtained from waste cotton fibers was introduced into the Ag-doped g-C3N4/TiO2 hybrid composite through a facile one-step hydrothermal process. The morphology, elemental composition, crystal structure, microstructure, specific surface area, chemical bonding state, energy band structure, and separation efficiency of photoinduced charge carriers of the resultant composite were examined using scanning electron microscope, energy dispersive x-ray spectrometer, x-ray diffractometer, transmission electron microscope, surface area analyzer, x-ray photoelectron spectroscope, ultraviolet–visible spectrophotometer, ultraviolet photoelectron spectroscope, and photoluminescence spectroscope. The adsorption isotherms, kinetics and thermodynamics of the biochar, Ag-doped g-C3N4/TiO2 and Ag-doped biochar/g-C3N4/TiO2 were evaluated using the model methyl orange dye. The photoacatalytic degradation of the model pollutants including methyl orange, methylene blue, congo red, and tetracycline hydrochloride and the photocatalytic reduction of Cr(VI) ions were also assessed under visible light. Experimental results indicated that the photocatalytic property of the Ag-doped biochar/g-C3N4/TiO2 was significantly enhanced through the synergic effects compared with the Ag-doped g-C3N4/TiO2. This was due to the uniform doping of multi-scale porous biochar with g-C3N4 nanosheet, Ag and TiO2 nanoparticles. The adsorptive enhancement induced by the biochar resulted in the narrowed band gap, suitable electronic energy band structure, and fast separation of photoinduced charge carriers of the Ag-doped biochar/g-C3N4/TiO2, which was probably due to the coexistence of multi-valence Ti+4/+3 and Ag0/+1 species and oxygen-containing groups of biochar. The major reactive species of the Ag-doped biochar/g-C3N4/TiO2 were 1O2 and h+. The MO dye adsorption onto the Ag-doped biochar/g-C3N4/TiO2 followed the Langmuir isotherm model, pseudo-first-order and pseudo-second-order kinetic models, and the adsorption process was an endothermic reaction with entropy reduction effects. As such, the Ag-doped biochar/g-C3N4/TiO2 exhibited a promising application for the treatment of wastewater containing multi-pollutants especially organic dyes and heavy metal ions.
Early-time measure in eternal inflation
Authors: Khoury Justin , Wong Sam S.C. 
Published: May 2022

Abstract
In a situation like eternal inflation, where our data is replicated at infinitely-many other space-time events, it is necessary to make a prior assumption about our location to extract predictions. The principle of mediocrity entails that we live at asymptotic late times, when the occupational probabilities of vacua has settled to a near-equilibrium distribution. In this paper we further develop the idea that we instead exist during the approach to equilibrium, much earlier than the exponentially-long mixing time. In this case we are most likely to reside in vacua that are easily accessed dynamically. Using first-passage statistics, we prove that vacua that maximize their space-time volume at early times have: 1. maximal ever-hitting probability; 2. minimal mean first-passage time; and 3. minimal decay rate. These requirements are succinctly captured by an early-time measure. The idea that we live at early times is a predictive guiding principle, with many phenomenological implications. First, our vacuum should lie deep in a funneled region, akin to folding energy landscapes of proteins. Second, optimal landscape regions are characterized by relatively short-lived vacua, with lifetime of order the de Sitter Page time. For our vacuum, this lifetime is ∼ 10130 years, which is consistent with the Standard Model estimate due to Higgs metastability. Third, the measure favors vacua with small, positive vacuum energy. This can address the cosmological constant problem, provided there are sufficiently many vacua in the entire ensemble of funnels. As a concrete example, we study the Bousso-Polchinski lattice of flux vacua, and find that the early-time measure favors lattices with the fewest number of flux dimensions. This favors compactifications with a large hierarchy between the lightest modulus and all other Kähler and complex structure moduli.