bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Moringa oleifera Lam. in cancer: Phytochemistry and pharmacological insights
Authors: Singh Jyoti , Gautam Dev Nath Singh , Sourav Simant , Sharma Rohit 
Published: November 2022

AbstractMoringa oleifera Lam. (M. oleifera), aka “Shigru,” “mother's best friend,” “miracle tree,” “horseradish tree,” “drumstick tree,” and “oil tree,” native of the sub‐Himalayan region of northern India, belongs to the Moringaceae family. The high nutritional value of M. oleifera makes it suitable for both nutritional and medicinal purposes. Because of its chemical constituents, M. oleifera is used to treat and combat malnutrition, especially in infants and nursing mothers. These days, herbal medicine and its phytocompound derivatives are also being recognized as effective complementary therapies for cancer treatment. So, in this study, M. oleifera is reviewed for its anticancer property. By thoroughly scanning the PubMed, Embase, SinoMed, and China National Knowledge Infrastructure databases, an extensive up‐to‐date report on its ethnomedicinal use, nutritional, phytochemistry, and pharmacotherapeutic potential is done. It has valuable nutrients such as vitamins, proteins, iron, calcium, antioxidants (flavonoids, carotenoids, and phenols) and ascorbic acid. Additionally, it is used as an antioxidant, anti‐inflammatory, antispasmodic, antimicrobial, anticancer, and antidiabetic agent. There are also concrete evidence that this plant's bioactive constituents, numerous extracts have a high biopotential in a number of cancer cells, through its antioxidative, anti‐inflammatory, antiproliferative, and cell cycle arresting properties. This extensive literature review will provide insights into several mechanisms and signaling pathways of its various phytoconstituents that can mitigate the growth of cancer cells in various experimental models, safety and toxicity concerns, and drug–drug interactions.
Virginia Game Fish Tagging Program: A Nontraditional Data Source for Fisheries Management
Authors: Musick Susanna , Gillingham Lewis , Perkinson Matt , Teears Thom 
Published: November 2022

Abstract
Since 1995, the Virginia Game Fish Tagging Program (VGFTP) has collected data for recreationally important marine fishes in cooperation with skilled volunteers. These trained anglers tagged more than 380,000 fishes since 1995 and contributed data regarding fish movement and site fidelity patterns of species captured and released in the Chesapeake Bay and Atlantic coastal waters. Over time, the VGFTP has become an important source of data for fishery managers and program data are included in stock assessments for species such as Cobia Rachycentron canadum. Best management practices from the VGFTP show that cooperative science programs that collect data for management should have mandatory hands-on training with quality control mechanisms in place for submitted data. Further, fishery managers, statisticians, and stakeholders should work together to identify the data needs for statistical viability before volunteers start collecting information. Finally, data objectives and project results should be shared with the stakeholders who collected the data, in addition to fishery managers.
Recreational Angler Contributions to Fisheries Management Are Varied and Valuable: Case Studies from South Florida
Authors: Gervasi Carissa L , Massie Jordan A , Rodemann Jonathan , Trabelsi Shakira , Santos Rolando O , Rehage Jennifer S 
Published: November 2022

Abstract
Recreational fisheries are complex social–ecological systems that are influenced by a variety of increasing stressors. In Florida (USA), recreational fishing is a US$9.2 billion industry and a vital aspect of the state's culture. However, many targeted species remain unregulated and understudied, which hinders identifying population declines or important ecological interactions. The complex nature of recreational fishing means traditional data collection and analysis methods for assessing stock status and trends are not always appropriate or feasible. Recently, fisheries scientists have begun to recognize the value and importance of angler knowledge, behavior, and collaboration, and how angler-derived data can complement existing biological data and provide new insights. The purpose of this study was to present an overview of three methods for involving anglers in research and provide case studies from South Florida that demonstrate the success of these approaches for assessing and managing recreational fisheries.
A Collaborative Aerial Survey of Coastal Pelagic Species in Nearshore California Waters
Authors: Lynn Kirk , Dorval Emmanis , Porzio Dianna , Nguyen Trung 
Published: November 2022

Abstract
Pacific Sardine Sardinops sagax and Northern Anchovy Engraulis mordax are commercially important West Coast fish stocks managed within the Coastal Pelagic Species (CPS) complex by the Pacific Fishery Management Council and National Marine Fisheries Service. Before 2020, survey indices used in Pacific Sardine stock assessments did not explicitly account for nearshore biomass, which presumably had been relatively small compared to the total biomass of the population, but since 2015, has been a more substantial component of total biomass. During the recent Pacific Sardine stock decline, the California Department of Fish and Wildlife and the California Wetfish Producers Association collaborated on an aerial survey off California to estimate nearshore (within 3,600 m from shore) CPS biomass to inform assessments. This project has also involved federal fisheries biologists and Pacific Fishery Management Council advisory bodies and committees, representing a unique collaborative effort to improve data used in CPS fisheries management. We will discuss successes, issues, and challenges in implementing this nontraditional survey and how these data can continue to inform future stock assessments.
Effect of drying processes on the occurrence of lipid oxidation‐derived 4‐hydroxy‐2‐hexenal and 4‐hydroxy‐2‐nonenal in Spanish mackerel (Scomberomorus niphonius)
Authors: Cui Kexin , Liu Nan , Sun Yong , Sun Guohui , Wang Shanshan , Yang Min , Wang Xiaoli , Zhou Deqing , Ge Yinggang , Wang Dajun , Wang Mingli 
Published: November 2022

AbstractIn this study, dry‐cured Spanish mackerel (Scomberomorus niphonius, DCSM) was prepared via three different methods (hot‐air drying, cold‐air drying, and sun drying). The content of 4‐hydroxy‐2‐hexenal (HHE) and 4‐hydroxy‐2‐nonenal (HNE) derived from lipid oxidation in whole processes was investigated by HPLC‐MS/MS. The changes in fatty acid composition were detected by GC‐MS, and the degree of lipid oxidation was evaluated by the levels of acid values (AV), peroxide values (POV), and thiobarbituric acid‐reactive substances (TBARS). The results showed that the drying process significantly accelerated lipid oxidation in DCSM. The contents of HHE and HNE were significantly increased after processing. The content of HHE was higher by 18.44‐, 13.45‐, and 16.32‐folds compared with that of HNE after three different processes, respectively. The HHE and HNE contents fluctuated upward during the hot‐air and cold‐air drying process. However, the contents of HHE and HNE increased time‐dependent during the sun drying process, with the highest values of 86.33 ± 10.54 and 5.29 ± 0.54 mg/kg fish among the three different processes. Besides, there was a significant positive correlation between HHE contents and n‐3 fatty acids content in hot‐air drying and sun drying processes (Pearson's r = .991/.996), and HNE occurrence was closely related to n‐6 fatty acid content in sun drying process (Pearson's r = .989). Regression analysis indicated that the content of HHE and TOTOXTBA values in DCSM showed good linear relationships (R2 value = .907), which suggested that the content of HHE could be used to estimate the oxidative deterioration of dry‐cured fish products.
Effect of Poling on Photocatalysis, Piezocatalysis, and Photo–Piezo Catalysis Performance of BaBi4Ti4O15 Ceramics
Authors: Kumar Pushpendra , Vaish Rahul , Sung Tae Hyun , Hwang Wonseop , Park Hyeong Kwang Benno , Kumar Anuruddh , Kebaili Imen , Boukhris Imed 
Published: November 2022

AbstractThis study focuses on analyzing the poling effect of BaBi4Ti4O15 (BBT) on the basis of photo and piezo‐catalysis performance. BBT powder is prepared via a solid state reaction followed by calcination at 950 °C for 4 h. BBT is characterized by an X‐ray diffractometer, scanning electron microscopy, Raman spectroscopy, and X‐ray photoelectron spectroscopy. The optical bandgap of BBT is evaluated with the help of Tauc's plot and found to be 3.29 eV, which comes in the photon energy range of ultra‐violet radiation. BBT powder is poled by using Corona poling in the presence of 2 kV mm−1 of electric field. An aqueous solution of methyl blue (MB) dye in the presence of UV radiation is used to evaluate the photo/piezocatalysis performance. Photocatalysis, piezocatalysis, and photo–piezo catalysis degradation efficiencies of poled and unpoled BBT powder are tested for 120 min of UV light irradiation. Photo–piezocatalysis shows degradation efficiencies of 62% and 40% for poled and unpoled BBT powder, respectively. Poling of BBT powder shows significant enhancement in degradation performance of MB dye in aqueous solution. Scavenger tests are also performed to identify reactive species.
In vivo grading of lipids in fatty liver by near‐infrared autofluorescence and reflectance
Authors: Lifante José , de la Fuente‐Fernández María , Román‐Carmena Marta , Fernandez Nuria , Jaque García Daniel , Granado Miriam , Ximendes Erving 
Published: November 2022

AbstractThe prevalence of nonalcoholic fatty liver (NAFLD) is rapidly increasing worldwide. When untreated, it may lead to complications such as liver cirrhosis or hepatocarcinoma. The diagnosis of NAFLD is usually obtained by ultrasonography, a technique that can underestimate its prevalence. For this reason, physicians aspire for an accurate, cost‐effective, and noninvasive method to determine both the presence and the specific stage of the NAFLD. In this paper, we report an integrated approach for the quantitative estimation of the density of triglycerides in the liver based on the use of autofluorescence and reflectance signals generated by the abdomen of obese C57BL6/J mice. Singular value decomposition is applied to the generated spectra and its corresponding regression model provided a determination coefficient of 0.99 and a root mean square error of 240 mg/dl. This, in turn, enabled the quantitative imaging of triglycerides density in the livers of mice under in vivo conditions.
Marginalized youth participation in a civic engagement and leadership program: Photovoice and focus group empowerment activity
Authors: Koren Ainat , Mottola Elena 
Published: November 2022

AbstractTo evaluate marginalized youth participation in a civic engagement and leadership program accompanied by a photovoice activity. This study employed an exploratory qualitative method through semistructured focus group discussions among 11 participating teens, as well as 63 photographs from the photovoice activity and their accompanied narratives. The data was coded, and themes related to teens concerns and workshop impact were summarized. Focus group and photovoice analyses showed similar themes related to the experience of participants empowerment, identity recognition, community awareness, and desire for civic engagement. Participants conveyed concerns about gender and race discrimination, community drug abuse, littering, teen pregnancy, and overcrowded schools. This study has implications for professionals and researchers engaging with marginalized teens in the community. Photovoice methodology can complement any program that has teen empowerment among their goals of allowing participants to have a voice.
Predictors of burnout, compassion fatigue, and compassion satisfaction experienced by community health workers offering maternal and infant services in New York State
Authors: Rahman Rahbel , Ross Abigail M. , Huang Debbie , Kirkbride Gwyneth , Chesna Sharon , Rosenblatt Cassidy 
Published: November 2022

AbstractAlthough burnout has been increasingly well studied among medical (nurses, physicians, residents) and mental health providers (psychologists, psychiatrists, social workers), there continues to be a lack of attention on the well‐being of community‐based providers, such as Community Health Workers (CHWs), within the United States. Using cross‐sectional data from 75 CHWs employed in 14 agencies funded through the Maternal and Infant Community Health Collaboratives Initiative (MICHC) in New York, our study examined predictors (anxiety, physical health, adverse childhood experiences, job satisfaction, role certainty, demographic and work characteristics) of burnout, compassion fatigue (CF) and compassion satisfaction (CS). Descriptive statistics were used to characterize our sample and linear regression was employed to investigate the correlates of burnout, CF and CS. Results indicated that CHWs with higher levels of anxiety and lower job satisfaction were more likely to have higher burnout scores. CHWs with higher levels of anxiety, lower job satisfaction and fewer days of poorer health were more likely to report higher CF. Those who worked more than 35 h per week were less likely to report higher CS. The study provides recommendations for organizational‐level interventions to address risk factors of burnout and CF and promote CS among CHWs, such as bolstering supervision, encouraging greater communication, offering recognition/appreciation of CHWs and creating opportunities for self‐care. Findings should be considered when designing organizational‐level preventive measures that mitigate burnout and CF and promote CS.
An update on maternal cardiac hemodynamics in fetal growth restriction and pre‐eclampsia
Authors: Dall'Asta Andrea , Minopoli Monica , Ramirez Zegarra Ruben , Di Pasquo Elvira , Ghi Tullio 
Published: November 2022

AbstractPre‐eclampsia and fetal growth restriction (FGR) have been long related to primary placental dysfunction, caused by abnormal trophoblast invasion. Nevertheless, emerging evidence has led to a new hypothesis for the origin of pre‐eclampsia and FGR. Suboptimal maternal cardiovascular adaptation has been shown to result in uteroplacental hypoperfusion, ultimately leading to placental hypoxic damage with secondary dysfunction. In this review, we summarize current evidence on maternal cardiac hemodynamics in FGR and pre‐eclampsia. We also discuss the different approaches for antihypertensive treatment according to the hemodynamic phenotype observed in pre‐eclampsia and FGR.
Effectiveness and safety of dolutegravir and raltegravir for treating children and adolescents living with HIV: a systematic review
Authors: Townsend Claire L. , O'Rourke John , Milanzi Edith , Collins Intira Jeannie , Judd Ali , Castro Hannah , Vicari Marissa , Jesson Julie , Leroy Valériane , Renaud Françoise , Penazzato Martina 
Published: November 2022

AbstractIntroductionGlobally about 1.7 million children were living with HIV in 2020. Two integrase strand transfer inhibitors, dolutegravir and raltegravir, are increasingly used in children. We conducted a systematic review to assess the effectiveness and safety of dolutegravir and raltegravir in children and adolescents living with HIV, aged 0–19 years.MethodsSources included MEDLINE, Embase, the Cochrane Library, clinical trial registries, abstracts from key conferences and reference list searching. Observational studies and clinical trials published January 2009–March 2021 were eligible. Outcomes included efficacy/effectiveness (CD4 counts and viral load) and/or safety outcomes (mortality, grade 3/4 adverse events and treatment discontinuation) through 6 months or more post‐treatment initiation. Risk of bias was assessed using previously published tools appropriate for the study design. Narrative syntheses were conducted.Results and discussionIn total, 3626 abstracts and 371 papers were screened. Eleven studies, including 2330 children/adolescents, reported data on dolutegravir: one randomized controlled trial (RCT; low risk of bias), one single‐arm trial (unclear risk of bias) and nine cohort studies (three low risk of bias, two unclear risk and four high risk). Ten studies, including 649 children/adolescents receiving raltegravir, were identified: one RCT (low risk of bias), one single‐arm trial (low risk of bias) and eight cohort studies (four low risk of bias, three unclear risk and one high risk). Viral suppression levels in children/adolescents at 12 months were high (>70%) in most studies assessing dolutegravir (mostly second‐ or subsequent‐line, or mixed treatment lines), and varied from 42% (5/12) to 83% (44/53) at 12 months in studies assessing raltegravir (mostly second‐ or subsequent‐line). Across all studies assessing dolutegravir or raltegravir, grade 3/4 adverse events (clinical and/or laboratory) were reported in 0–50% of subjects, few resulted in discontinuation, few were drug related and no deaths were attributed to either drug.ConclusionsThese reassuring findings suggest that dolutegravir and raltegravir are effective and safe as preferred regimens in children and adolescents living with HIV. With the rollout of dolutegravir in paediatric populations already underway, it is critical that data are collected on safety and effectiveness in infants, children and adolescents, including on longer‐term outcomes, such as weight and metabolic changes.
DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS‐STING‐triggered innate immune activation
Authors: Lou Meng , Huang Dingbo , Zhou Zhenbang , Shi Xinyu , Wu Miaowei , Rui Yajuan , Su Jiaming , Zheng Wenwen , Yu Xiao‐Fang 
Published: November 2022

AbstractCellular infections by DNA viruses trigger innate immune responses mediated by DNA sensors. The cyclic GMP–AMP synthase (cGAS)‐stimulator of interferon gene (STING) signaling pathway has been identified as a DNA‐sensing pathway that activates interferons in response to viral infection and, thus, mediates host defense against viruses. Previous studies have identified oncogenes E7 and E1A of the DNA tumor viruses, human papillomavirus 18 (HPV18) and adenovirus, respectively, as inhibitors of the cGAS‐STING pathway. However, the function of STING in infected cells and the mechanism by which HPV18 E7 antagonizes STING‐induced Interferon beta production remain unknown. We report that HPV18 E7 selectively antagonizes STING‐triggered nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) activation but not IRF3 activation. HPV18 E7 binds to STING in a region critical for NF‐κB activation and blocks the nuclear accumulation of p65. Moreover, E7 inhibition of STING‐triggered NF‐κB activation is related to HPV pathogenicity but not E7–Rb binding. HPV18 E7, severe acute respiratory syndrome coronavirus‐2 open reading frame 3a, human immunodeficiency virus‐2 viral protein X, and Kaposi's sarcoma‐associated herpesvirus KSHV viral interferon regulatory factor 1 selectively inhibited STING‐triggered NF‐κB or IRF3 activation, suggesting a convergent evolution among these viruses toward antagonizing host innate immunity. Collectively, selective suppression of the cGAS‐STING pathway by viral proteins is likely to be a key pathogenic determinant, making it a promising target for treating oncogenic virus‐induced tumor diseases.
Investigation of effect of the profile of screw flight on chocolate flow in 3D printing using an improved lattice Boltzmann method
Authors: Wu Weiwei , Deng Xu , Ding Shuang , Zhang Yanjun , Wei Xinlong 
Published: November 2022

AbstractBACKGROUND3D printing provides a new way of molding chocolate with complex geometrical structures. The screw extruder can efficiently transport the liquid chocolate, which has been adopted to investigate the effect of the profile of the screw flight on the flow. First, the rheological behavior of the liquid chocolate is measured and the Cross equation is demonstrated as the proper rheological model. Then, based on the rheological behavior, an improved lattice Boltzmann method is creatively proposed, for which the effectiveness is validated by the classical Poiseuille flow. Third, the geometrical structure of the screw extruder is analyzed and transformed. The possible changes in the profiles of the screw flights are listed. Finally, the fluid analysis is conducted and the necessary streamlines figures, cloud charts and velocity distributions are obtained.RESULTSThe large dip angle in straight cases has an obvious effect on the velocity distribution and the common flow area. The position of the convex point is the additional important factor, whereas the concave profiles are the most moderate in the proposed cases.CONCLUSIONThe changes in the profiles will affect the chocolate flow. The work is significant for extrusion theory in 3D printing. © 2022 Society of Chemical Industry.
Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study
Authors: Schol Jordy , Sakai Daisuke , Warita Takayuki , Nukaga Tadashi , Sako Kosuke , Wangler Sebastian , Tamagawa Shota , Zeiter Stephan , Alini Mauro , Grad Sibylle 
Published: November 2022

AbstractIntroductionCell transplantation shows promising results for intervertebral disc (IVD) repair, however, contemporary strategies present concerns regarding needle puncture damage, cell retention, and straining the limited nutrient availability. Mesenchymal stromal cell (MSC) homing is a natural mechanism of long‐distance cellular migration to sites of damage and regeneration. Previous ex vivo studies have confirmed the potential of MSC to migrate over the endplate and enhance IVD‐matrix production. In this study, we aimed to exploit this mechanism to engender IVD repair in a rat disc degeneration model.MethodsFemale Sprague Dawley rats were subjected to coccygeal disc degeneration through nucleus pulposus (NP) aspiration. In part 1; MSC or saline was transplanted into the vertebrae neighboring healthy or degenerative IVD subjected to irradiation or left untouched, and the ability to maintain the IVD integrity for 2 and 4 weeks was assessed by disc height index (DHI) and histology. For part 2, ubiquitously GFP expressing MSC were transplanted either intradiscally or vertebrally, and regenerative outcomes were compared at days 1, 5, and 14 post‐transplantation. Moreover, the homing potential from vertebrae to IVD of the GFP+ MSC was assessed through cryosection mediated immunohistochemistry.ResultsPart 1 of the study revealed significantly improved maintenance of DHI for IVD vertebrally receiving MSC. Moreover, histological observations revealed a trend of IVD integrity maintenance. Part 2 of the study highlighted the enhanced DHI and matrix integrity for discs receiving MSC vertebrally compared with intradiscal injection. Moreover, GFP rates highlighted MSC migration and integration in the IVD at similar rates as the intradiscally treated cohort.ConclusionVertebrally transplanted MSC had a beneficial effect on the degenerative cascade in their neighboring IVD, and thus potentially present an alternative administration strategy. Further investigation will be needed to determine the long‐term effects, elucidate the role of cellular homing versus paracrine signaling, and validate our observations on a large animal model.