bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study
Authors: Zhao Mei , Liu Chuan-Fen , Feng Yu-Fei , Chen Hong 
Published: August 2022

Introduction: Polypharmacy are commonly observed among older adults with cardiovascular disease. However, multiple medications lead to increased risk of drug-drug interactions (DDIs). Therefore, identification and prevention actions related to harmful DDIs are expected in older adults. The study aimed to describe the prevalence of potential DDIs (pDDIs) in discharge prescriptions among older adults with chronic coronary syndrome (CCS).Methods: A single-center cross-sectional study was performed in a tertiary public hospital in Beijing, China. CCS patients aged 65 years and above who were admitted to cardiology wards over a 3-month period and alive at discharge were included. Electronic medical records and discharge prescriptions were reviewed. pDDIs were evaluated through the Lexi-Interact online.Results: pDDIs were identified in 72.9% of the 402 individuals (n = 293). A total of 864 pDDIs were obtained. 72.1% of patients were found with C DDIs (n = 290) and 20.3% were categorized in D and X DDIs (n = 82). The only X DDI was between cyclosporine and atorvastatin. Under category D, glycemia alterations within antidiabetics and increased chances of bleeding with antithrombotic were the most common. Concomitant use of clopidogrel and calcium channel blockers was a frequent situation within category C, followed by synergic blood pressure lowering agents and increased rosuvastatin concentration induced by clopidogrel.Conclusion: DDIs exposure was common in older CCS. DDIs screening tools should be introduced to alert potential adverse effects. Prescribers need to rigorously review or modulate therapies to prevent DDI-related adverse outcomes. Clinical pharmacists should be more involved in complex drug regimen management.
Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome
Authors: Zaklyazminskaya Elena , Shestak Anna , Podolyak Dmitry , Komoliatova Vera , Makarov Leonid , Novitskaya Anna , Revishvili Amiran 
Published: August 2022

Brugada syndrome (BrS) is an inherited cardiac arrhythmia characterized by ST-elevation, negative T-wave, and a high risk of sudden cardiac death (SCD) due to ventricular tachycardia. It is associated with mutations in over 20 genes but only SCN5A is recommended for routine genetic screening. This study was performed to estimate diagnostic yield and pathogenicity assessment of rare genetic variants in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome (BrS). Targeted genes panel sequencing of the five genes were screened using IonTorrent PGM with following Sanger confirmation. Detailed clinical evaluation of 75 unrelated BrS probands with a deep phenotyping of SCN5A (+) probands was performed. Twelve rare genetic variants (six missense, six truncating) were initially identified and classified as disease-causing. Reassessment of the clinical significance in the light of the current guidelines revealed: 2 Pathogenic (P) variants; 8 Likely Pathogenic (LP); two missense variants (p.G274S and p. S1778H) were re-classified later as a variant of uncertain significance (VUS). Unique VUS (p.Arg100Ser) was detected in the SCN4B gene. Lone Brugada-pattern was observed in 46% probands; 54% patients had concomitant arrhythmias. PR interval, the only electrocardiography parameter correlating with SCN5A-mutation, was longer (207 ± 24 ms) than normal in SCN5A (+) probands. SCD cases were registered in 31 families. Depression was the only recurring extra-cardiac complaint in SCN5A (+) probands; it was self-reported in five SCN5A (+) probands, and co-segregated with Brugada pattern in 2 families. After variants reassessment, the ratio of SCN5A (+) probands with Brugada syndrome accounts for 13% in Russian cohort.
What influences informal caregivers' risk perceptions and responses to home care safety of older adults with disabilities: A qualitative study
Authors: Cao Songmei , Huang Huanhuan , Bo Suping , Feng Man , Liang Yiqing , Liu Yuqing , Zhao Qinghua 
Published: August 2022

ObjectiveThis study aimed to explore the factors that influence risk perceptions and responses by informal caregivers of older adults with disabilities.MethodsA descriptive qualitative study was performed, and the socio-ecological framework was applied to interpret the complex influences on individual risk perceptions and responses. Semistructured interviews were conducted with 16 informal caregivers of older adults with disabilities. The interviews were transcribed verbatim and analyzed using content analysis.ResultsThe four levels of the socio-ecological framework successfully allowed for the analysis of influences on the risk perceptions and responses of informal caregivers as follows: at the individual level: previous experiences, personality characteristics, health literacy, and care burden; at the familial level: economic status, emotional connection, informational and decisional support; at the community level: health service accessibility and neighbor communication; and at the social level: responsibility-driven culture, media advocacy, and aging policies.ConclusionsThe establishment of risk perceptions and coping behaviors by informal caregivers was affected by many factors. Using the framework to interpret our findings provided insight into the influence of these varying factors. Comprehensive, realistic, and achievable strategies are needed for improving the risk perceptions of informal caregivers in home care by addressing personal, familial, and social environmental factors.
The effect of horticultural therapy on depressive symptoms among the elderly: A systematic review and meta-analysis
Authors: Zhang Ya Wei , Wang Jun , Fang Tian Hong 
Published: August 2022

ObjectiveThis systematic review and meta-analysis aimed to assess the effectiveness of horticultural therapy on depressive symptoms in the elderly and determine the potential moderators of the intervention effect.MethodsIn early June 2022, randomized controlled trials and Quasi-experimental studies were searched on Web of Science, PsycINFO, CINAHL, EMBASE, Medline, PubMed, CNKI, WANFANG DATA, and CQVIP. Three independent authors proposed the following inclusion criterion for this study: the elderly with applied horticultural therapy intervention compared to non-HT intervention. From a total of 3,068 records, only 34 studies met the inclusion criteria. After the full-text screening, 13 studies were included in the analysis. An assessment of the risk of bias was conducted using RoBINS-I and RoB 2 tools. The comprehensive Meta-Analysis 3.3 tool was used for the meta-analysis.ResultsMeta-analysis suggested that mean depression scores of elderly people who underwent horticultural therapy intervention were significantly lower than those who did not receive HT therapy. More significant effects were found for the elderly with mean age equal to or over 75 years instead of younger than 75 years, in randomized controlled trials instead of quasi-experimental studies, for studies with more than 20 participants receiving horticultural therapy at the same time and place instead of equal to or fewer than 20 horticultural therapy participants.ConclusionsThis evidence supported that horticultural therapy had a significant positive effect on the depressive symptoms outcomes for the elderly. Therefore, our data revealed that horticultural therapy could be considered as a part of therapy in depressive symptoms reduction programs. Due to the high degree of heterogeneity and the limited number of studies, a future review is warranted to determine the effects of horticultural therapy on depressive symptoms reduction in the elderly.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=272464, identifier: CRD42021272464.
Klebsiella pneumoniae liver abscess with purulent meningitis and endogenous endophthalmitis: A case report
Authors: Li Fang , Zheng Wenfei , Yu Jian , Zhao Linyan 
Published: August 2022

This is a rare but typical case of a Klebsiella pneumoniae liver abscess with migratory infections including purulent meningitis and endogenous endophthalmitis. The patient had a chief complaint of 7 days of fever, 4 days of blurry vision, and 4 h of glossolalia. Ultrasound scan and computed tomography (CT) suggested a liver abscess. Both blood and drainage fluid cultures grew K. pneumoniae with a high mucosal phenotype. The patient was finally diagnosed with a K. pneumoniae liver abscess, purulent meningitis, and endogenous K. pneumoniae endophthalmitis in the right eye. Ultrasound-guided percutaneous catheter drainage (PCD) of the liver abscess was performed, and meropenem was used to control infection. The patient was given 0.1 ml of vancomycin (10 g/L) and 0.1 ml of ceftazidime (20 g/L) were by intravitreal injection for the treatment of endophthalmitis. The infection was gradually controlled after such treatments. The patient was discharged from our hospital with an improved condition. However, during the time of follow-up, she developed complications due to severe pneumonia and eventually died in a local hospital. This case revealed that a rapid diagnosis followed by appropriate treatment would improve prognosis and prevent severe metastatic complications.
Postoperative paralytic ileus following debulking surgery in ovarian cancer patients
Authors: Egger Eva K. , Merker Freya , Ralser Damian J. , Marinova Milka , Vilz Tim O. , Matthaei Hanno , Hilbert Tobias , Mustea Alexander 
Published: August 2022

AimThis study aims to evaluate the incidence of postoperative ileus (POI) following cytoreductive surgery in epithelial ovarian cancer (EOC) patients and its impact on anastomotic leakage occurrence and postoperative complications.MethodsA total of 357 surgeries were performed on 346 ovarian cancer patients between 1/2010 and 12/2020 at our institution. The postoperative course regarding paralytic ileus, anastomotic leakage, and postoperative complications was analyzed by Fisher's exact test and through ordinal logistic regression.ResultsA total of 233 patients (65.3%) returned to normal gastrointestinal functions within 3 days after surgery. A total of 123 patients (34.5%) developed POI. There were 199 anastomoses in 165 patients and 24 leakages (12.1%). Postoperative antibiotics (p 0.001), stoma creation (p 0.0001), and early start of laxatives (p 0.0048) significantly decreased POI, while anastomoses in general (p 0.0465) and especially low anastomoses (p 0.0143) showed increased POI rates. Intraoperative positive fluid excess &gt;5,000 cc was associated with a higher risk for POI (p 0.0063), anastomotic leakage (p 0.0254), and severe complications (p 0.0012).ConclusionPostoperative antibiotics, an early start with laxatives, and stoma creation were associated with reduced POI rates. Patients with anastomoses showed an increased risk for POI. Severe complications, anastomotic leakages, and POI were more common in the case of intraoperative fluid balance exceeding 5,000 cc.
Dietary Vitamin K Intake and HPV-Infection Status Among American Women: A Secondary Analysis From National Health and Nutrition Examination Survey Data From 2003 to 2016
Authors: Jiang Yinhui , Xu Shu , Lan Jinzhi , Zhang Jinjuan , Chen Tengxiang 
Published: August 2022

Objective: Cervical cancer is a serious potential risk to women’s health, and is closely related to persistent HPV infection. Vitamin K mainly existed in green vegetables, fruit, and dairy products. This research aims to observe the association between vitamin K and HPV-infection.Methods: 13,447 participants from the NHANES were selected. Dietary vitamin K intake was used as the objective independent variable and continuous variable, HPV-infection status was used as the outcome variable, and characteristics of selected participants were used as the covariates.Results: There was a nonlinearity between vitamin K intake and HPV-infection, and the inflection point is 3.81 of log2 vitamin K intake. In a range of 0–3.81, Each one-unit increase in log2 vitamin K intake was associated with a 43% reduction in the risk of HPV infection. When log2 vitamin K intake excess of 3.81, the risk of HPV infection did not continue to decline. The HPV-subtype was not associated with vitamin K intake.Conclusion: There is a nonlinearity between vitamin K intake and HPV-infection status. But HPV-subtype was not associated with vitamin K intake.
Loneliness and Depression Among Female University Students During the COVID-19 Pandemic: A Cross-Sectional Study in Riyadh, Saudi Arabia, 2020
Authors: Alateeq Deemah , Aljabri Alhanouf , Aldogiam Ghada , Alajmi Haya , Alsoqaih Hussah , Alfadhly Rawan , Alshahrani Raneem 
Published: August 2022

Objectives: Quarantine-related loneliness has impacted university students during the coronavirus disease 2019 (COVID-19) pandemic. This study aims to evaluate loneliness among female university students in Riyadh, Saudi Arabia during the pandemic and to investigate its correlation with depression.Methods: A sample of 753 female students was collected during the first COVID-19 summer vacation outbreak through a cross-sectional survey that consisted of two parts: 1) Sociodemographic characteristics and COVID-19 related questions; 2) The eight-item UCLA Loneliness Scale (ULS-8) and the Patient Health Questionnaire-9 (PHQ-9).Results: Most participants were between 18 and 22 years old (75.2%) and were studying at humanities college (61.50%). Loneliness and depression were reported among 63.3% and 41.1% of female students, respectively, and the correlation between them was significantly positive (beta = 0.419, p &lt; 0.001). Having a previous history of a psychiatric condition and families with insufficient monthly income were the main associated factors with high levels of loneliness and depression.Conclusion: Female university students experienced loneliness and depression under quarantine during the first COVID-19 summer vacation outbreak. Psychosocial intervention for the vulnerable groups is essential, as are longitudinal studies.
Serological Assessment of Ascaris suum Exposure in Greek Pig Farms and Associated Risk Factors Including Lawsonia intracellularis
Authors: Tassis Panagiotis , Symeonidou Isaia , Gelasakis Athanasios I. , Kargaridis Michalis , Aretis George , Arsenopoulos Konstantinos V. , Tzika Eleni , Papadopoulos Elias 
Published: August 2022

The effects of nematodes and bacteria on intestinal health are of primary importance in modern swine production. The aim of the present study was to assess the seropositivity status of Ascaris suum infection in fatteners in intensive swine farms in Greece and address possible risk factors, including Lawsonia intracellularis as a predisposing factor to swine ascariosis. In total, 360 blood serum samples from pigs in the late fattening period, from 24 Greek swine farrow-to-finish farms (15 samples/farm) were collected and tested with Svanovir® A. suum antibody ELISA and Ileitis antibody ELISA. The results demonstrated 34.4% seropositive samples for A. suum and 42.2% for L. intracellularis. The analysis of predisposing risk factors suggested that the frequency of application of anthelminthic treatment to sows more than two times per year was significantly associated with the lower likelihood of A. suum infection, whereas a greater likelihood of A. suum infection was observed in pigs with concurrent L. intracellularis exposure. The results highlight the importance of proper anthelminthic metaphylaxis of the breeding stock, as well as the likely outcome of concurrent exposure to two intestinal pathogens in pigs, implying a possible association between intestinal nematodes and bacteria in swine.
Clinical and morphophysiological hepatic alterations caused by the ingestion of food with added ricinoleic acid esters a bioactive with acaricidal potential
Authors: Sodelli Luís Fernando , Calligaris Izabela Braggião , De Souza José Ribamar Lima , Da Silva Odaiza , Araújo Bruna Jéssyca Nascimento , Rodrigues Milena de Lima , Camargo-Mathias Maria Izabel 
Published: August 2022

The present study investigated the effects of castor oil ricinoleic acid through analysis of blood biochemical parameters and the liver morphology of female rabbits (animal model). The results of Bioassay 1 and Bioassay 2 showed that the reference indexes of the hepatic enzymes alkaline phosphatase, gamma-glutamyl transferase, and alanine aminotransferase were not significantly altered. However, the hepatic enzyme aspartate aminotransferase of the rabbits tested in Bioassay 2 presented alterations, suggesting a hepatotoxic effect of the esters. The morphological and histological data showed that the liver of the rabbits fed with the ester-added food presented the following alterations: a) disorganization of the hepatic cords; b) an increase in intercellular spaces; c) hepatocytes with barely evident cell limits; and d) hepatocytes with irregular and pyknotic nuclei, in most cases displaced to the periphery of the cell due to extensive vacuolation. The histochemical analysis showed that the hepatocytes of the rabbits fed with commercial food with added esters had a decrease in lipid content and an increase in the levels of stored cytoplasmic glycogen.
الاندماج كوسيلة قانونية لإعادة هيكلة شركات التأمين المتعثرة
Authors: عمر قائد , نافع خالص 
Published: August 2022

تستلزم التطورات الاقتصادية والتجارية التي ترتبط بأنشطة وأعمال الشركات العاملة في قطاع التأمين، التعامل مع انعكاساتها وتبعاتها التي قد تطال وجود تلك المنشأت نفسها أو تستوجب إعادة هيكلتها للتأقلم مع آثار وتغيرات ظروف المنافسة حفاظاً على حصصها وأرباحها في السوق العاملة فيه، ولما كانت عمليات الاندماج من أهم الوسائل القانونية التي تشكل حلولاً لمواجهة المشاكل والصعوبات الناشئة عن تلك التطورات، فإن القوانين عموماً خصتها بأحكام ينتظمها إطار قانوني يحدد إجراءات وآثار الاندماج الصحيح القائم على سبب مشروع.
إذ أصحبت عملية الاندماج بين شركات التأمين في سبيل إعادة هيكلتها واحدة من ضرورات العصر الذي نعيش واقعه الأن في ظل العولمة، عبر خطة لإعادة هيكلة هذه الشركات لإقالتها من عثرتها ومساعدتها على الخروج من هذه الحالة، إذ أن شركات التأمين الأن تعيش واقعاً جديداً ومختلفاً في ظل ازدياد احجامها وأعدادها، والتنوع والتعدد في الخدمات التأمينية المقدمة مما يفرض عليها أن تكون أسرع وأكثر مرونة وكفاءة من أجل النجاح والاستمرار.
السلطة المختصة بالتراخيص الإدارية
Authors: محمد ايناس , محمد رشا 
Published: August 2022

تمارس الجهة الإدارية (الإدارة) نشاطها أو عملها من خلال شكلين من الأعمال فهذا العمل الإداري الذي تنصرف فيه نية السلطة الإدارية (الإدارة) الى إحداث أثر قانوني معين والتراخيص الإدارية كأي قرار إداري أخر هو عمل أو تصرف قانوني مكتمل العناصر، ويكون بشكل أوامر وإلزام أو الخطر وسواء كانت جهة الإدارة مقيدة أو تقديرية في مزاولة سلطتها في مجال التراخيص فهي لابد أن لا تخرج عن إطار المشروعية.
وعليه وللإحاطة بذلك نقسم دراستنا الى ثلاث مباحث، نتناول في الأول منه التعريف بالتراخيص الإدارية، وفي الثاني منه نبين الجهة المختصة بالتراخيص الإدارية في القانون المقارن، أما الثالث نسلط الضوء على السلطة المختصة بالتراخيص الإدارية في القانون العراقي ومن ثم تختم دراستنا بجملة من الاستنتاجات والتوصيات.
Boron ion implantation on femtosecond-laser-irradiated diamond surface
Authors: Okada Tatsuya , Bando Kenya , Iwaasa Fumiya , Ueki Tomoyuki , Hisazawa Hiromu , Tomita Takuro 
Published: August 2022

Abstract
We investigated the effect of femtosecond-laser-induced surface modifications on ion incorporation into diamond crystals. The (001) surface of a diamond crystal was irradiated with femtosecond laser pulses. Boron ions were implanted on the laser-irradiated surface of two crystals: one at 600 °C and the other at room temperature. The ion concentration along the depth of the crystal was measured with secondary ion mass spectroscopy. The concentration profile was parabolic, and in the deeper region after the peak, the ion concentration was higher in the irradiated area than in the nonirradiated area in both crystals. That is, the introduction of laser-induced surface modifications enhanced the ion migration along the depth direction. Transmission electron microscopy showed that the crystallinity of diamond was better in the crystal subjected to high-temperature implantation. These results support the idea that femtosecond-laser-induced surface modifications can enhance dopant incorporation into diamond while preserving the diamond’s crystallinity.
تأثير الأسلوب التعلم التعاوني في تعلم أداء بعض المراحل الفنية لفعالية رمي الرمح والانجاز لدى طلاب المرحلة الإعدادية
Authors: Dr. Adel Hamid Obaid  
Published: August 2022

تعد العاب القوى من أهم الألعاب الفردية في العالم والتي تمارس على نطاق واسع وتشمل على فعاليات كثيرة منها الجري لمسافات القصيرة والمسافات الطويلة والمارثون فضلاً عن فعاليات الرمي وفعاليات القفز والوثب والتي تحتاج الى مناهج تعليمية وتدريبية من أجل تطوير هذه الفعاليات.
من أجل النهوض بالمستوى الجيد للمدارس الاعدادية في فعاليات العاب القوى بكافة انشطتها وطرائق وأساليب تعليمها وتدريبها المتنوعة بما يلائم مستويات الفئات العمرية التي توجد في هذه المدارس يحتم على المدرس أن يكون ملماً بشكل جيد بأساليب وطرائق التدريس كافة.
تكمن أهمية هذا البحث في تطبيق الأسلوب التعاوني أحد أساليب التعلم الفعال من خلال اعداد منهاج تعليمي لتعليم عينة البحث من طلبة المدارس الاعدادية من الذين يتعلمون المهارة لأول مرة، وهدف البحث الى معرفة تأثير أسلوب التعلم التعاوني في تعلم الأداء الفني في فعالية رمي الرمح لطلبة المرحلة الإعدادية، وتم اختيار اعدادية المتميزين للبنين التابعة الى مديرية تربية الرصافة الأولى بالطريقة العمدية وذلك لوجود الساحات المناسبة لمزاولة العاب القوى ومنها رمي الرمح وتم اختيار عينة البحث وهم طلاب الصف الخامس الاعدادي بالطريقة العمدية والبالغ عددهم(198)طالباً موزعين على ستة شعب وتم اختيار شعبة (ب) والبالغ عدد طلابها (33)طالباً عن طريق القرعة، ان أهم مرحلة من مراحل تعلم رمي الرمح هيه الركضة التقربية والخطوات الخمسة وكذلك رمي الرمي الرمح والثبات بصورة جيدة، وقد تم اعداد المنهاج ضمن الأسلوب التعاوني والذي يعني بتقسيم الطلبة في مجموعات وتكليفهم بعمل يقومون به مجتمعين متعاونين على وفق هيكلية تنظيمية للعمل الجماعي بحيث يقومون افراد كل مجموعة بالتعاون والاندماج فيما بينهم من أجل التعلم وفق أدوار واضحة ومحددة مع التأكيد ان كل عضو في المجموعة يتعلم المادة التعليمية المطلوبة، وان التعلم يحدث في أجواء مريحة خالية من التوتر والقلق، وهذا مما يؤدي الى ان ترتفع دافعية الطلبة بشكل كبير مما يتيح للطالب التكيف بشكل كبير مع هذه المراحل المؤثرة مما يؤدي الى تحسن كبير في الأداء، وبعد الانتهاء من تطبيق المنهاج التعليمي تم اجراء الاختبارات البعدية وبعد معالجة نتائج الاختبارات عن طريق استخدام الحقيبة الإحصائية (SPSS) أظهرت الاستنتاجات تفوق المجموعة التجريبية على المجموعة الضابطة في الاختبارات البعدية وذلك نتيجة استخدام المجموعة التجريبية أسلوب التعلم التعاِوني على الأسلوب التقليدي (الأمري) المتبع المستخدم لدى المجموعة الضابطة ، وجاءت التوصيات بضرورة استخدام أسلوب التعلم التعاوني في تعلم هذه المهارة أو مهارات أخرى وبما يضمن ارتقاء والتحسن في الأداء بمستوى الطلبة.
ألغزل في الرؤية الحداثية للشعر
Authors: Mohamed Taha Yassin  
Published: August 2022

يحاول النقد الحديث التعبيرعن المضامين الشعريّة بطرق جديدة ، تستطيع تلبية متطلبات التطوّر الثقافيّ للإنسان ، فالغزل بنوعيه العذريّ والصريح يأخذ مناحي جديدة في التأويل لكي يكون أكثر سعة وشموليّة ، محاولا توسيع الفهم الضيّق للغزل، و النقد الحديث يبحث عن لامحدوديّة الأفق الشعريّ وعن مثاليّة الحبّ العذريّ، ويعتمد الإثارة وسعة الخيال للتأثير في المتلقي ، وبالتالي التوسع العقليّ لفهم اللغة وقابليتها على التطور من خلال المدلولات الجديدة التي تلبي متطلبات المرحلة.