bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of a pharmacy residency resiliency program for PGY1 and PGY2 residents: Program structure and resident perceptions
Authors: Kneuss Tiffany G , Wolff Alexandra S , Meadors Patrick L , Reynolds Danya R , Hammer John M 
Published: April 2022

Abstract

Purpose
To describe the implementation of a pharmacy residency resiliency program (PRRP) for postgraduate year 1 (PGY1) and postgraduate year 2 (PGY2) pharmacy residents, including program structure, strengths and weaknesses/limitations, resident perceptions as captured by a postprogram survey, generalizability to other institutions, and opportunities for future directions.

Summary
Pharmacy residents face significant pressure, workload, and stressors that put them at risk for burnout and depression. While resiliency has been a major area of focus to help combat these risks for healthcare professionals, little has been published regarding formal, structured resiliency training in pharmacy, especially in pharmacy residency programs. American Society of Health-System Pharmacists (ASHP) residency standards recommend that programs consider education related to burnout prevention and that mitigation strategies be provided to residents and other pharmacy personnel, but no formal pharmacy-specific programs or strategies have been established. We implemented a 12-month PRRP for PGY1 and PGY2 pharmacy residents and conducted a postprogram survey to assess resident perceptions and to identify areas for growth.

Conclusion
Implementation of a PRRP was feasible and could be replicated at other institutions. Residents in our program reported a high level of satisfaction, skills gained, and positive attributes of the addition of the PRRP. Some notable factors contributing to success included the program’s longitudinal nature, use of a nonpharmacy facilitator, and impactful content from an established resiliency skills curriculum.
Are Lower-Strength Beers Gateways to Higher-Strength Beers? Time Series Analyses of Household Purchases from 64,280 British Households, 2015–2018
Authors: Jané Llopis Eva , O’Donnell Amy , Kaner Eileen , Anderson Peter 
Published: April 2022

Abstract

Aims
Buying and consuming no- (per cent alcohol by volume, ABV = 0.0%) and low- (ABV = &gt;0.0% and ≤ 3.5%) alcohol beers could reduce alcohol consumption but only if they replace buying and drinking higher-strength beers. We assess whether buying new no- and low-alcohol beers increases or decreases British household purchases of same-branded higher strength beers.

Methods
Generalized linear models and interrupted time series analyses, using purchase data of 64,280 British households from Kantar Worldpanel’s household shopping panel, 2015–2018. We investigate the extent to which the launch of six new no- and low-alcohol beers affected the likelihood and volume of purchases of same-branded higher-strength beers.

Results
Households that had never previously bought a same-branded higher-strength beer but bought a new same-branded no- or low-alcohol beer were less than one-third as likely to go on and newly buy the same-branded higher-strength product. When they did later buy the higher-strength product, they bought half as much volume as households that had not bought a new same-branded no- or low-alcohol beer. For households that had previously purchased a higher-strength beer, the introduction of the new same-branded no- or low-alcohol beer was associated with decreased purchases of the volume of the higher-strength beer by, on average, one-fifth.

Conclusions
The increased availability of new no- and low-alcohol beers does not seem to be a gateway to purchasing same-branded higher-strength beers but rather seems to replace purchases of these higher-strength products. Thus, introduction of new no- and low-alcohol beers could contribute to reducing alcohol consumption.
SARS-CoV-2 Infection Rates Following Use of Regular Compared With Defective Respirators When Caring for COVID-19 Patients: A Retrospective Follow-up Study
Authors: Kolstad Henrik A , Frydenberg Morten , Nielsen Kent Jacob , Schlünssen Vivi , Biering Karin , Kjærsgaard Mona , Vestergaard Jesper Medom , Würtz Else Toft , Pugdahl Kirsten , Würtz Anne Mette Lund , Hansen Karoline Kærgaard , Jespersen Sanne , Kragh Thomsen Marianne , Sørensen Mette Marie , Ellermann-Eriksen Svend , Dvinge Redder Jacob , Storgaard Merete 
Published: April 2022

Abstract

Background
There is strong observational evidence that respirators are highly effective in protecting the users from being infected with Middle East respiratory syndrome and severe acute respiratory syndrome coronavirus (SARS-CoV), but the evidence for SARS-CoV-2 during daily work is limited. This study utilized a subset of healthcare workers’ temporary use of a new brand respirator with frequent defects when caring for coronavirus disease 2019 (COVID-19) patients to assess the protective effect of regular respirators against SARS-CoV-2 infection.

Methods
We retrospectively followed 463 participants wearing a regular respirator and 168 wearing the new brand respirator day-by-day when caring for COVID-19 patients until testing polymerase chain reaction positive for SARS-CoV-2 between 27th December 2020 and 14th January 2021.

Results
We observed seven and eight incident SARS-CoV-2-infected cases. This corresponded with daily infection rates of 0.2 and 0.5%, an incidence rate ratio of 0.4 [95% confidence interval (CI) 0.1; 1.0], and an incidence rate difference of 0.3% (95% CI −0.1; 0.8) when comparing a regular with the new brand respirator.

Discussion
We regard the new brand respirator a sham intervention, and this study thus provides further evidence for the protective effect of respirators when exposed to SARS-CoV-2 virus.
Validation of a COVID-19 Job Exposure Matrix (COVID-19-JEM) for Occupational Risk of a SARS-CoV-2 Infection at Work: Using Data of Dutch Workers
Authors: van der Feltz Sophie , Peters Susan , Pronk Anjoeka , Schlünssen Vivi , Stokholm Zara A , Kolstad Henrik A , van Veldhoven Karin , Basinas Ioannis , van Tongeren Martie , Burdorf Alex , Oude Hengel Karen M 
Published: April 2022

Abstract

Objectives
A COVID-19 Job Exposure Matrix (COVID-19-JEM) has been developed, consisting of four dimensions on transmission, two on mitigation measures, and two on precarious work. This study aims to validate the COVID-19-JEM by (i) comparing risk scores assigned by the COVID-19-JEM with self-reported data, and (ii) estimating the associations between the COVID-19-JEM risk scores and self-reported COVID-19.

Methods
Data from measurements 2 (July 2020, n = 7690) and 4 (March 2021, n = 6794) of the Netherlands Working Conditions Survey-COVID-19 (NWCS-COVID-19) cohort study were used. Responses to questions related to the transmission risks and mitigation measures of Measurement 2 were used to calculate self-reported risk scores. These scores were compared with the COVID-19-JEM attributed risk scores, by assessing the percentage agreement and weighted kappa (κ). Based on Measurement 4, logistic regression analyses were conducted to estimate the associations between all COVID-19-JEM risk scores and self-reported COVID-19 (infection in general and infected at work).

Results
The agreement between the COVID-19-JEM and questionnaire-based risk scores was good (κ ≥ 0.70) for most dimensions, except work location (κ = 0.56), and face covering (κ = 0.41). Apart from the precarious work dimensions, higher COVID-19-JEM assigned risk scores had higher odds ratios (ORs; ranging between 1.28 and 1.80) on having had COVID-19. Associations were stronger when the infection were thought to have happened at work (ORs between 2.33 and 11.62).

Conclusions
Generally, the COVID-19-JEM showed a good agreement with self-reported infection risks and infection rates at work. The next step is to validate the COVID-19-JEM with objective data in the Netherlands and beyond.
SimPlot++: a Python application for representing sequence similarity and detecting recombination
Authors: Samson Stéphane , Lord Étienne , Makarenkov Vladimir 
Published: April 2022

AbstractMotivationAccurate detection of sequence similarity and homologous recombination are essential parts of many evolutionary analyses.ResultsWe have developed SimPlot++, an open-source multiplatform application implemented in Python, which can be used to produce publication quality sequence similarity plots using 63 nucleotide and 20 amino acid distance models, to detect intergenic and intragenic recombination events using Φ, Max-χ2, NSS or proportion tests, and to generate and analyze interactive sequence similarity networks. SimPlot++ supports multicore data processing and provides useful distance calculability diagnostics.Availability and implementationSimPlot++ is freely available on GitHub at: https://github.com/Stephane-S/Simplot_PlusPlus, as both an executable file (for Windows) and Python scripts (for Windows/Linux/MacOS).
Indocyanine green (ICG) fluorescence imaging for prevention of anastomotic leak in totally minimally invasive Ivor Lewis esophagectomy: a systematic review and meta-analysis
Authors: Casas María A , Angeramo Cristian A , Bras Harriott Camila , Dreifuss Nicolás H , Schlottmann Francisco 
Published: April 2022

Summary

Background
Indocyanine green (ICG) fluorescence imaging is an emerging technology that might help decreasing anastomotic leakage (AL) rates. The aim of this study was to determine the usefulness of ICG fluorescence imaging for the prevention of AL after minimally invasive esophagectomy with intrathoracic anastomosis.

Methods
A systematic literature review of the MEDLINE and Cochrane databases was performed to identify all articles on totally minimally invasive Ivor Lewis esophagectomy. Studies were then divided into two groups based on the use or not of ICG for perfusion assessment. Primary outcome was anastomotic leak. Secondary outcomes included operative time, ICG-related adverse reactions, and mortality rate. A meta-analysis was conducted to estimate the overall weighted proportion and its 95% confidence interval (CI) for main outcomes.

Results
A total of 3,171 patients were included for analysis: 381 (12%) with intraoperative ICG fluorescence imaging and 2,790 (88%) without ICG. Mean patients’ age and proportion of males were similar between groups. Mean operative time was also similar between both groups (ICG: 354.8 vs. No-ICG: 354.1 minutes, P = 0.52). Mean ICG dose was 12 mg (5–21 mg). No ICG-related adverse reactions were reported. AL rate was 9% (95% CI, 5–17%) and 9% (95% CI, 7–12%) in the ICG and No-ICG groups, respectively. The risk of AL was similar between groups (odds ratio 0.85, 95% CI 0.53–1.28, P = 0.45). Mortality was 3% (95% CI, 1–9%) in patients with ICG and 2% (95% CI, 2–3%) in those without ICG. Median length of hospital stay was also similar between groups (ICG: 13.6 vs. No-ICG: 11.2 days, P = 0.29).

Conclusion
The use of ICG fluorescence imaging for perfusion assessment does not seem to reduce AL rates in patients undergoing minimally invasive esophagectomy with intrathoracic anastomosis.
The Impact of Vedolizumab and Ustekinumab on Articular Extra-Intestinal Manifestations in Inflammatory Bowel Disease Patients: A Real-Life Multicentre Cohort Study
Authors: De Galan Cara , Truyens Marie , Peeters Harald , Mesonero Gismero Francisco , Elorza Ainara , Torres Paola , Vandermeulen Liv , Jauregui Amezaga Aranzazu , Ferreiro-Iglesias Rocio , Holvoet Tom , Zabana Yamile , Reverter Laia Peries , Gonzales Gerard Bryan , Geldof Jeroen , Varkas Gaëlle , De Vos Martine , Lobatón Triana 
Published: April 2022

Abstract

Background and Aims
Extra-intestinal manifestations are frequently reported in inflammatory bowel diseases. However, data comparing the effect of vedolizumab and ustekinumab on articular extra-intestinal manifestations are limited. The aim here was to evaluate differences in new-onset and the evolution of pre-existing joint extra-intestinal manifestations during both treatments.

Methods
An international multicentre retrospective study was performed on inflammatory bowel disease patients who started vedolizumab or ustekinumab between May 2010 and December 2020. Extra-intestinal manifestations were assessed at baseline and joint extra-intestinal manifestations were evaluated throughout the 2-year follow-up. Arthropathy was defined by joint inflammation [arthritis/sacroiliitis], diagnosed by a rheumatologist, and arthralgia as articular pain without confirmed inflammation. Additionally, skin, ocular and hepatic extra-intestinal manifestations were assessed at baseline. Uni- and multivariate analyses were performed.

Results
In total, 911 patients [vedolizumab: 584; ustekinumab: 327] were included. Deterioration of pre-existing arthropathy and rate of new-onset arthropathy were not significantly associated with vedolizumab over ustekinumab. Arthropathy was used as reason to stop treatment in six vedolizumab and two ustekinumab patients. The odds of developing new arthralgia within 6 months was higher in patients who took vedolizumab compared to ustekinumab (adjusted odds ratio [aOR]: 2.28 [1.01–5.15], p = 0.047). However, this effect was not sustained during the 2-year follow-up (aOR: 1.35 [0.80-2.29], p = 0.259). Deterioration of pre-existing arthralgia was comparable between ustekinumab and vedolizumab-treated patients. In two vedolizumab-treated patients arthralgia was given as the reason to stop treatment.

Conclusions
Vedolizumab and ustekinumab can be used safely in patients with articular extra-intestinal manifestations. Only a temporary increased risk for developing arthralgia has been observed under vedolizumab.
OR54. Relationship Between Degree of Smoking Based on the Brinkman Index and Mean Tunica Intima-Media Thickness of the Carotid Artery (CIMT) in Young Adult Patients in H. Badaruddin Kasim Tabalong Regional Hospital, South Kalimantan
Authors: Nariswari R , Yutanto D 
Published: April 2022

Abstract

Background and Aims
This study is to analyse the relationship between the degree of smoking based on the Brinkman Index and mean carotid intima-media thickness (CIMT) in young adult patients in H Badaruddin Kasim Tabalong Hospital.

Method and Results
This cross-sectional study included 38 patients undergoing medical check-up. The smoking degree was measured at the time of the medical checkup in H Badruddin Kasim Tabalong Hospital between February April March 2019. The subjects were categorised into three groups based on the Brinkman Index, mild smokers (n = 19), moderate smokers (n = 19), and there was no patient in the heavy smoker group (n = 0), according to their responses to a questionnaire. We compared the CIMT in the three groups after adjusting for age. CIMT was measured using doppler ultrasound. The analysis used by Pearson correlation and independent samples test (t-test). Multivariate analysis performed using linear regression. In both right and left carotid artery assessment, carotid intima-media thickness was significantly increased in moderate smoker group (p = 0.008 and p = 0.013, respectively). There was a significant positive correlation between Brinkman Index and carotid intima-media thickness (p = 0.08, r = 0.425). The smoking period was significantly associated with carotid intima-media thickness in both right and left carotid artery (p = 0.001, p = 0.013, respectively). There was no significant association between the number of cigarettes consumed and carotid intima-media thickness.

Conclusion
The Brinkman Index is positively correlated with mean carotid intima-media thickness.
OR69. The impact of hypertension on clinical outcome of hemorrhagic stroke patients
Authors: Pinzon R T , Nunsio P N 
Published: April 2022

Abstract

Background and Aims
Hypertension is the hallmark of stroke that both increases the incidence and worsens the outcome of stroke. Hypertension is prevalent in the stroke population and is the most important modifiable risk factor for stroke. The purpose of this study was to determine the impact of hypertension on the clinical outcome of hemorrhagic stroke patients.

Methods and Result
This was a retrospective study using secondary data from the electronic stroke registry of Bethesda Hospital Yogyakarta, Indonesia. The data is taken from the beginning to the end of 2020. The outcomes of the study were death, disability, and independence. This study used SPSS 2.0 with a significance level of 0,05. Among 431 patients with hemorrhagic stroke, 250 (58,0 %) were males and the majority of patients were in the age group 61-70 years, which was 131 (30.4%). Patients with hemorrhagic stroke who had hypertension as a comorbid had a worse outcome. On the death outcome, 169 (91,8 %) patients had hypertension as a comorbid, and 19 (8,2 %) did not. In the disability outcome, 152 (80.9%) patients had hypertension and 36 (19.1%) did not. Meanwhile, in the independence outcome, patients with hypertension were fewer in number than those without, namely 21 patients (35.6%) vs. 38 patients (64.4%). (p &lt; 0,05)

Conclusion
Clinical outcomes are worse in hemorrhagic stroke patients with comorbid hypertension than in those without. Blood pressure management in hemorrhagic stroke patients is urgently needed to improve clinical outcomes in hemorrhagic stroke patients.
C64. New Onset PVC Bigeminy Post Covid-19 Infection: Another Covid-Cardiac Related Problem
Authors: Jeremiah B , Lubis A C , Hasan H 
Published: April 2022

Abstract

Background
Covid-19 is an infectious disease caused by a newly discovered coronavirus that caused acute severe respiratory syndrome and other complication. Many cardiac complication already occurred such as carditis and acute heart failure. PVC bigeminy is a new complication that we found in our post covid-19 patient.

Case Summary
A 31-years-old female patient admitted to the outpatient department with chief complaint palpitation with chest discomfort in the past 1 month with a history covid-19 infection 3 months ago with prolong covid infection for 2 months. ECG showed sinus rhythm and bigeminy PVC with PVC LBBB morphology left inferior axis and transition zone in V4. The patient planned to do Electrophysiology study and ablation. From the EP study we found 2 type of PVC, both of the PVC have LBBB morphology with left inferior axis and transitional zone in V4. The first PVC had 42ms earliest activation time and the second PVC had 48ms earliest activation. We do ablation with non irrigating catheter on the first PVC but the PVC still remain. Then try with irrigating catheter and do the ablation. After the ablation the PVC already vanished and the ablation was successful.

Discussion
PVC bigeminy post covid-19 infection is a rare complication in covid-19 patient. PVC bigeminy cause several complain from palpitation, chest discomfort, and shortness of breath. Ablation is one of the best way to treat PVC bigeminy patient with symptoms and in the patient the ablation was successful.
The importance of mentors and how to handle more than one mentor
Authors: Marshall Andrea G , Brady Lillian J , Palavicino-Maggio Caroline B , Neikirk Kit , Vue Zer , Beasley Heather K , Garza-Lopez Edgar , Murray Sandra A , Martinez Denise , Shuler Haysetta D , Spencer Elsie C , Morton Derrick J , Hinton Antentor Jr 
Published: April 2022

Abstract
Working with multiple mentors is a critical way for students to expand their network, gain opportunities, and better prepare for future scholastic or professional ventures. However, students from underrepresented groups (UR) are less likely to be mentored or have access to mentors, particularly in science, technology, engineering, and mathematics (STEM) fields. We developed and implemented a workshop, to provide the necessary foundation for students to be better prepared for establishing future mentorships throughout graduate and professional school. Faculty well-versed in the area of effective mentorship from multiple universities developed and delivered a 1.5-hour workshop to address the roles of a mentor, especially when it comes to UR students, and how students may effectively work with multiple mentors. This workshop was delivered to a group of students from, the Historically Black College and University (HBCU), Winston-Salem State University, and a pre/post-10-point Likert scale-based survey was administered where 1 represented strongly disagree and 10 was strongly agree. The questions used in this seminar were newly designed by the authors as program evaluations. We analyzed the raw data with nonparametric tests for comparison within paired samples. Wilcoxon matched-pairs and signed-rank tests showed statistically significant growth in student self-ratings related to the workshop learning objectives. The ‘How to Handle More than One Mentor to Achieve Excellence’ workshop was well-received as a component of pregraduate and preprofessional training. Incorporating workshops like this may increase student preparedness around developing and cultivating healthy mentorship relationships throughout STEM training.
Enrichment of Non-B-Form DNA at D. melanogaster Centromeres
Authors: Patchigolla Venkata S.P. , Mellone Barbara G. 
Published: April 2022

Abstract
Centromeres are essential chromosomal regions that mediate the accurate inheritance of genetic information during eukaryotic cell division. Despite their conserved function, centromeres do not contain conserved DNA sequences and are instead epigenetically marked by the presence of the centromere-specific histone H3 variant centromeric protein A. The functional contribution of centromeric DNA sequences to centromere identity remains elusive. Previous work found that dyad symmetries with a propensity to adopt noncanonical secondary DNA structures are enriched at the centromeres of several species. These findings lead to the proposal that noncanonical DNA structures may contribute to centromere specification. Here, we analyze the predicted secondary structures of the recently identified centromere DNA sequences of Drosophila melanogaster. Although dyad symmetries are only enriched on the Y centromere, we find that other types of noncanonical DNA structures, including melted DNA and G-quadruplexes, are common features of all D. melanogaster centromeres. Our work is consistent with previous models suggesting that noncanonical DNA secondary structures may be conserved features of centromeres with possible implications for centromere specification.
Assessing Patterns and Stability of ADL Hierarchical Scales for Functional Disability Assessment
Authors: Fong Joelle H , Youn Yongjoon 
Published: April 2022

Abstract

Background and Objectives
This study examined the stability over time of activities of daily living (ADL) items in 3 comparable longitudinal data sets and evaluated ADL loss sequences for older adults in the United States, South Korea, and Japan.

Research Design and Methods
Data from the U.S. Health and Retirement Study, and its 2 international sister surveys, were analyzed. Participants were community-dwelling adults aged 60 and older. For each data set, Rasch analysis was implemented to determine if the ordering of items remained stable across multiple waves (2006–2014), such that a single ADL hierarchy may be derived from multiwave data.

Results
Data fitted the Rasch model well. Item calibrations were sufficiently stable across measurement periods in each data set, reflecting a stable frame of reference. Results were also robust to sample variations. The derived ADL hierarchies based on scaled logit scores revealed that “dressing” and “bathing” were relatively more difficult items for older adults in all study populations.

Discussion and Implications
Scale stability is essential when exploiting longitudinal data to analyze patterns in ADL disabilities. The consistency in ADL scales across measurement periods supports their use as screening tools and identifying those at risk for transitions in care. Interventions to reduce dependency in bathing and dressing can help improve independent functioning for community-dwelling older adults.