bluuebunny/crossref_metadata_2025_split huggingface dataset:
EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice
Authors: Szabo Roman , Ward Jerrold M. , Artunc Ferruh , Bugge Thomas H. 
Published: June 2022

ABSTRACT
Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein expressed on the surface of most epithelial and epithelium-derived tumor cells and reported to regulate stability of epithelial tight junction proteins, claudins. Despite its widespread expression, loss of EPCAM function has so far only been reported to prominently affect intestinal development, resulting in severe early onset enteropathy associated with impaired growth and decreased survival in both humans and mice. In this study, we show that the critical role of EPCAM is not limited to intestinal tissues and that it shares its essential function with its only known homolog, Trophoblast cell surface antigen 2 (TROP2). EPCAM-deficient mice show significant growth retardation and die within 4 weeks after birth. In addition to changes in small and large intestines, loss of EPCAM results in hyperkeratosis in the skin and forestomach, hair follicle atrophy leading to alopecia, nephron hypoplasia in the kidney, proteinuria, and altered production of digestive enzymes by the pancreas. Expression of TROP2 partially, but not completely, overlaps with EPCAM in a number developing epithelia. Although loss of TROP2 had no gross impact on mouse development and survival, TROP2 deficiency generally compounded developmental defects observed in EPCAM-deficient mice, led to an approximately 60% decrease in embryonic viability, and further shortened postnatal lifespan of born pups. Importantly, TROP2 was able to compensate for the loss of EPCAM in stabilizing claudin-7 expression and cell membrane localization in tissues that co-express both proteins. These findings identify overlapping functions of EPCAM and TROP2 as regulators of epithelial development in both intestinal and extraintestinal tissues.
How to treat acne in women with polycystic ovary syndrome (PCOS)? Review of the available literature
Authors: Zygmunt Ewelina , Wróblewski Hubert , Zimna Aleksandra , Chojęta Dariusz , Kozłowska Anna 
Published: June 2022

Acne vulgaris is one of the most common chronic skin diseases among people between 15 and 40 years of age.[i] It would seem that it is a typical disease of adolescence. However, it also very often affects adults. One of the most common causes of acne vulgaris in adult women is polycystic ovary syndrome (PCOS). The hyperandrogenism and metabolic disorders present in this syndrome may contribute to the formation of blackheads, pimples, and cysts on the face, chest and back. This article focuses on a review of current acne treatments associated with polycystic ovary syndrome.

[i] Stern RS. Medication and medical service utilization for acne 1995-1998. J Am Acad Dermatol 2000; 43: 1042-1048
Penggunaan Multi Process Welding Machine Untuk Menunjang Kegiatan Praktikum Pengelasan Pada Laboratorium Pengelasan Kapal (Welding School) Sekolah Vokasi
Authors: Dwi Cahyo Indro 
Published: June 2022

The existence of a laboratory is very necessary to fulfill curriculum a chievements. Because laboratory is a mandatory facility to hold any practical classes. Undip Vocational School of Marine Construction Engineering Technology Study Program is using the 2020th "Kampus Merdeka" curriculum, in which one of the practical classes is welding and carried out at the Ship Welding Laboratory using a Multi-Process Welding Machine. The purpose of the welding practicum provision is to find out the results of welding that carried out by students using data collection method and conducting experimental settings that are adjust ed to the welding data reading. Welding process using SMAW integration of amperage and voltage with due regard to the WPS procedure. From several samples of welding results, it can be seen that some parts may have welding defects. Welding with the SMAW method using an E6013 electrode with a diameter of 2.6 mm, and with a plate thickness of 10 mm at 50 - 70 amperes, whilst for a 5 mm plateat 48 - 65 amperes, but also depends on the welding clock flown and position.
Regularity and normality in hereditary bi m-spaces
Authors: Al-Omari Ahmad , Al Ghour Samer , Noiri Takashi 
Published: June 2022

Abstract
Quite recently, a new minimal structure

m

H

⋆

{m}_{H}^{\star }

and an

m
n

mn

-

ℋ

g

{{\mathcal{ {\mathcal H} }}}_{g}

-closed set have been introduced in a previous study [T. Noiri and V. Popa, Closed sets in hereditary bi m-spaces, Questions Answers General Topol. 38 (2020), 133–142] by using two minimal structures m,

n

n

and a hereditary class

ℋ

{\mathcal{ {\mathcal H} }}

. In this paper, we introduce and investigate the notions of

(

m
,
n

)

\left(m,n)

-

ℋ

g

⋆

{{\mathcal{ {\mathcal H} }}}_{g}^{\star }

-regularity and

(

m
,
n

)

\left(m,n)

-

ℋ

g

⋆

{{\mathcal{ {\mathcal H} }}}_{g}^{\star }

-normality in a hereditary bi m-space

(

X
,
m
,
n
,
ℋ

)

\left(X,m,n,{\mathcal{ {\mathcal H} }})

.
Releasing the Brake: Germany’s National Fiscal Rule No Longer Ensures Compliance with European Fiscal Rules
Authors: Buettner Thiess 
Published: June 2022

Abstract
This short paper highlights the role of the national fiscal rule, the so-called debt brake, for limiting Germany’s general government deficit. It argues that Germany was only able to comply with the European deficit limit, after this rule has been introduced in 2011. However, due to the creation of large special budgets, the debt brake no longer ensures compliance with the European fiscal rules.
Relevant Attributes Influencing Consumers’ Tomato Acceptance: A Systematic Review and Research Agenda
Authors: Latino Maria Elena , Menegoli Marta , Corallo Angelo 
Published: June 2022

Abstract
During the last two decades several studies were developed to understand the attributes able to affect consumer vegetable choice over the world. Focusing on fresh and processed tomato product, this study proposes a systematic literature review to systematize and critically apprise the current body of knowledge in this research field. In order to discover suggestions useful to enhance market strategies and policies about vegetable intake, the discovered tomato attributes were categorized, according the Search Experience and Credence logic, into: price, product features, packaging, convenience, brand, sensory properties, sustainability, origin, safety and health, production processes. By synthesizing the review findings, a multi-dimensional integrative content framework was conceived with the aim to maps the extant literature with multiple levels of analysis: antecedent, phenomenon and consequences. As part of the review, a future research agenda, theoretical and practical implications were discussed.
The multinomial convolution sum of a generalized divisor function
Authors: Park Ho 
Published: June 2022

AbstractThe main theorem of this article is to evaluate and express the multinomial convolution sum of the divisor functionσr♯(n;N/4,N){\sigma }_{r}^{\sharp }\left(n;\hspace{0.33em}N\hspace{-0.08em}\text{/}\hspace{-0.08em}4,N)in as a simple form as possible, whereN/4N\hspace{-0.08em}\text{/}\hspace{-0.08em}4is an arbitrary odd positive integer. This generalizes previous result in combination with Cho and Kim, which is about the caseN=4N=4. While obtaining our main theorem, we derive some generalizations of other identities to the case that we are dealing with.
Vibration signal acquisition and computer simulation detection of mechanical equipment failure
Authors: Wang Yonggang , Jagota Vishal , Makhatha Mamookho Elizabeth , Kumar Pawan 
Published: June 2022

Abstract
The author in order to solve the problem of optimizing the accuracy of mechanical equipment failure detection proposes a vibration signal collection and computer simulation detection for mechanical equipment failure. Using wavelet domain Wiener filtering-based mechanical equipment fault detection method, the author first combined Wiener filtering and wavelet threshold filtering, established a vibration signal collection model for mechanical equipment, obtained the true signal and the filtered signal error and fusion of the principle of wavelet threshold filtering to perform orthogonal wavelet transform on noisy signals, and through the principle of fast independent component analysis to separate the vibration signals of mechanical equipment, build the initial separation matrix of the signal with unit variance, and found the estimated value of the source signal; the collection of vibration signals of mechanical equipment is completed according to the estimated value, realizing the optimization of the detection of mechanical faults and equipment failures. The simulation results prove that the signal-to-noise ratio of the vibration signal of mechanical equipment collected by this method is higher than 15.7% of the signal-to-noise ratio based on the FastICA method; this is mainly because when this method is used for anti-interference collection of vibration signals of mechanical equipment, combining the principle of fast independent component analysis to separate the vibration signals of mechanical equipment, construct the initial separation matrix of the signal with unit variance. Using the proposed method for signal acquisition can greatly reduce the error, and it can provide effective support for fault detection of mechanical equipment.
Comparative assessment of Demerijian\'s and Cameriere\'s dental age estimation in children - A panaromic radiographic study
Authors: Govindraju Poornima , Srivastava Aparna , Pachipulusu Balaji , Kumar T S Mahesh 
Published: June 2022

Age estimation in children is a fundamental question in forensic medicine and in treatment planning. Estimation of age is required to answer a variety of legal questions like status of majority and criminal liability such as in child marriage, sexual harassment and in situations where birth data is lacking or doubted.Various methods have been proposed for assessment of the dental maturation, but the most widely applied method is by Demirijian et al. Cameriere’s method is also used to assess chronological age in children with open apex. With this background, the present study was conducted to estimate the dental age of the children from open and closed apex.240 digital panoramic radiograph of patients aged between 5 and 15 years were taken randomly Dental age estimation was performed using by Demirijians and Cameriere‘s method.The mean difference between the chronological and dental age was found to be 3.93 and 0.17 for Demirijian’s and Cameriere’s age estimation method respectively. In Demirijian’s method, the accuracy was found more in older females where as in Cameriere’s method the accuracy was almost same in all the age groups and the precision was seen in males than in females, on comparison Cameriere’s age estimation method was more accurate than Demirijian’s method.Dental maturity can be used to assess chronological age in children either by Demirijian’s or Cameriere’s method, Cameriere’s method was more accurate than Demirijian’s method.
The relationship between arch, loop and whorl fingerprint patterns with dental caries: A cross-sectional, descriptive institution-based study
Authors: Monpara Pooja C , Odedra Sima P , Shah Khushali H , Dodia Vaishali S , Pillai Jayasankar P , Yadav Sanjay 
Published: June 2022

Fingerprint analysis for personal identification is well-known, as it is unique to all individuals and remains unchanged over a lifetime. Now it is getting identified as a useful tool in understanding the basic questions in genetics and is emerging as an independent field in dentistry as dermatoglyphics. This study is carried out to evaluate the association between dermatoglyphic pattern and dental caries. The present study comprised total 200 individuals (100 male and 100 females) with age of 15 to 40 years, out of which 150 subjects included in group 1(with dental caries) and 50 individuals were included in group 2(without dental caries). DMFT score and fingerprint patterns of all 10 fingers were recorded in to proforma. These findings were tabulated and subjected to statistical analysis.Nearly 57.5% of group 1 patients had whorl pattern in their fingers followed by Loop patterns (38.13%) and arch pattern (4.4%). But in caries free group the Loop pattern was more frequent (75%), followed by whorl (21%) and arch patterns (3.6%). There was a significant difference in the distribution of whorl and loop pattern between caries and caries free group (p&#60;0.05). However, the arch pattern was not showing any significant difference in both the groups. The correlation analysis revealed significant negative and positive correlation for Loop and whorl pattern respectively when compared with the DMFT score. But the arch patterns were showing an insignificant negative correlation.An attempt to evaluate the association between fingerprint patterns and DMFT score was made in this present study. An individual's susceptibility to dental caries increases with whorl pattern incidence and decreases with loop pattern incidence. Hence it may be concluded that, fingerprint pattern could indicate a person’s susceptibility to dental caries. This method may be considered as a non-invasive, cost-efficient, time saving method while screening of prevalence of dental caries. Also, it might serve as effective tool in prevention of dental caries.
Does the current generation’s smile esthetics hinge on social media and cosmetic makeover? A questionnaire-based study
Authors: Batra Puneet , Karkun Rohit 
Published: June 2022

: Smile esthetics for today’s generation is an absolute necessity. It has been etched in people’s minds to present their best selves to gain acceptance from their peers. Social media with its filter/lens feature, photo editing options, and circulation of idealized celebrity photos have left a deep scar on the self-image of people. This has made individuals resort to cosmetic makeovers as a coping mechanism. 2 previously validated questionnaires were used. Specific items from both questionnaires were taken up which would fit the questionnaire while maintaining its essence. The final questionnaire was divided into 2 domains to understand the influence of social media and smile makeover individually. It comprised of 10 questions which were circulated via google form. 100 responses were received for the circulated questionnaire. For the social media domain, majority did not compare their smiles with that of others; were not very confident when it came to showing their smile on social media; often noticed the smile of others; and felt they had a good smile of their own. There was an even distribution when asked if they were conscious of their smile. For the cosmetic makeover domain, majority didn’t feel the need to get cosmetic procedures and were not influenced by social media into getting one.Results showed social media to have a big influence on improving smile esthetics. However, the same cannot be said for the desire of getting a cosmetic makeover as the majority didn’t feel the need for it.
Comparative Evaluation of Dexmedetomidine and Magnesium Sulphate in Mitigating Pressor Response while Extubation in Patients undergoing Mastoidectomies
Authors: Deshpande Jyoti Pushkar , Panse Neha Amey , Madke Eetasha Kailas 
Published: June 2022

Background: Ear surgeries performed under general anaesthesia mandate smooth emergence after surgery to facilitate a good surgical outcome. We conducted this study with primary objective of comparing dexmedetomidine and magnesium sulfate (MgSO4) in attenuating extubation response after mastoid surgeries. The secondary outcome was to study the adverse effects if any.
Methods: Sixty patients of ASA grade I and II, aged 18 -50 yrs were randomized into 2 groups of 30 each receiving either dexmedetomidine 0.5μg/kg or MgSO4 30 mg/kg respectively 10 minutes prior to completion of surgery. Efficacy of both drugs in attenuating cough reflex, PONV, shivering and fluctuations in haemodynamic response were recorded. Postoperative sedation was noted. Any laryngospasm, bronchospasm, hypotension, bradycardia, desaturation was also noted.
Statistical analysis: The observations were recorded and analysed using statistics calculator SPSS 19.00 version. Student’s t test and χ2 (chi square) test were used to analyze quantitative and qualitative data respectively. P-value<0.05 was considered statistically significant.
Results: The variations in systolic, diastolic blood pressure and heart rate were significantly less with dexmedetomidine as compared to MgSO4 (p<0.01). Incidence of coughing (p=0.002), PONV(p=0.002), was less with dexmedetomidine while shivering control was similar in both groups, the sedation was more with dexmedetomidine (p=0.004). Patients with dexmedetomidine infusion were more satisfied in terms of reduced nausea sensation, drowsiness.
Conclusion: Dexmedetomidine provides a smoother recovery profile as compared to MgSO4 when administered prior to extubation improving the surgical outcome and patient satisfaction in patients undergoing mastoidectomies.
SVC Syndrome in ICU: The Need of a Multidisciplinary Approach
Authors: Sandill Surabhi , Krishna Bhavya , Kohli Santvana , Jaiswal Binita 
Published: June 2022

Superior vena cava (SVC) syndrome, a potentially life threatening medical emergency, occurs due to SVC obstruction caused by extrinsic compression, intrinsic stenosis or thrombosis. Malignant mediastinal tumours account for more than 80% of cases of SVC syndrome. We hereby report a case of SVC syndrome who came with clinical features suggestive of SVC syndrome with dyspnea managed and diagnosed in the Intensive Care Unit with a multidisciplinary approach.
The Clinical Approach Toward Hereditary Persistence of Fetal Hemoglobin: A Case Report
Authors: Ghaderi Afshin , Bakhtiari Tahereh , Jokar Saeid , Eshraghi Abbas 
Published: June 2022

Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin. A steady increase of HbF in patients with hereditary persistence of fetal hemoglobin (HPFH) is associated with complications. The present report describes HPFH in a 26-year-old man with emphasis on its hemoglobin electrophoresis. The patient was admitted with complaints of recurrent weakness and lethargy, weight loss, abdominal pain, and dyspepsia. Splenectomy was planned due to massive splenomegaly and gastrointestinal complications. Ultimately, electrophoresis confirmed the diagnosis of HPFH.
Determination of the Effect of Freezing Methods on the Quality of Frozen Tomato Pieces
Authors: Rikasa A.M. , Senarathne S.M.A.C.U. , Wimalasiri K.M.S. 
Published: June 2022

Background: Due to their highly perishable nature, vegetables possess a higher chance of deterioration and damage after harvesting. Freezing is a potential preservation technique used to reduce the deterioration and increase the shelf life of vegetables by preventing the wastage of substantial quantities of tomatoes in Sri Lanka. Methods: In this research calcium chloride (2.4% w/w) pretreated Thilina and RIDA F1 tomato variety pieces were analyzed drip loss, pH, color, hardness, cutting shearing strength, ascorbic acid content and sensory parameters under air blast freezing (-30°C, 3 ms-1 air velocity) and conventional freezing (-18°C) conditions. Result: The L* values of colour, pH and ascorbic acid content were shown significant differences (p less than 0.05) but a*, b* values, driploss%, cutting and shearing strength didn’t show any significant differences (p less than 0.05) during different freezing conditions. The magnitude of color change (∆E) is higher (p less than 0.05) in conventional freezing treatment than in air-blast freezing. The preference among the panelists is significantly (p less than 0.05) higher for blast frozen tomato samples than conventional frozen samples concerning color, odor, texture and overall quality parameters. According to the statistical analysis, air blast freezing preserve better physiochemical and sensory parameters of Thilina and RIDA F1 tomato varieties.
Potensi Daun Kesambi (Schleicera Oleosa) Sebagai Kandidat Agent Anti Jamur Untuk Penyakit Onikomikosis (Infeksi Jamur Pada Kuku)
Authors: Khoiroh Zaimatul , Griana Tias Pramesti 
Published: June 2022

Onikomikosis merupakan infeksi jamur pada kuku yang disebabkan oleh jamur golongan dermatofita. Penelitian potensi daun kosambi (Schleicera oleosa) sebagai kandidat agent anti jamur untuk penyakit onikomikosis (infeksi jamur pada kuku) telah dilakukan. Daun kosambi (Schleicera oleosa) diekstrak menggunakan methanol. Telah diketahui ekstrak methanol daun kosambi berpotensi sebagai antijamur. Penelitian ini bertujuan membuktikan ekstrak daun Kosambi (Schleicera oleosa (Lour.) Oken) mampu menghambat pertumbuhan Trichophyton spp dan membuktikan daya hambat ekstrak daun Kosambi (Schleicera oleosa (Lour.) Oken) terhadap pertumbuhan Trichophyton spp. lebih baik daripada daya hambat obat ketokonazol sebagai drug of choice penyakit Onikomikosis. Pengujian dilakukan dengan metode cakram dengan perlakuan konsentrasi 5%, 10%, 15%, 20%, 25%, control negatif dengan DMSO 1% dan control positi ketokonazol 2%. Hasil menunjukkan bahwa ekstrak methanol daun kosambi mampu menghambat pertumbuhan Trichophyton spp dengan diameter zona hambat terbesar pada konsentrasi 25% yaitu 9,7mm. Key word: Trichophyton spp, Onikomikosi, Schleicera oleosa, agent anti jamur
Students' Perception and Readiness Level Toward Interprofessional Education (IPE) Before and After Program Implementation
Authors: Novianto Muhammad Rizal , Setiawan Abdul Malik , Mafaz Zidnal 
Published: June 2022

Background: The changing health system and the large number of patients presenting with chronic diseases require multi-disciplinary care. For this reason, Interprofessional Education (IPE) needs to be conducted to train teamwork between these health workers. Furthermore, to develop the IPE program at the faculty, it is necessary to have a good evaluation. In Kirkpatrick's evaluation model, an assessment of student perceptions and readiness can be carried out to evaluate IPE implementation. Therefore, the differences in perceptions and readiness at the beginning and after IPE implementation need to be carried out to assess the program. Objective: The purpose of this study is to find out the overview and comparison of perception and readiness level before and after the implementation of IPE. Methods: This research was a comparative quantitative study with a pre-experimental one-group pretest-posttest design with data collection using questionnaires. The type of data used in this study was primary data using Student Perception of Physician and Pharmacist Interprofessional Clinical Education (SPICE) and the Readiness for Interprofessional Learning Scale (RIPLS) questionnaires. 81 final semester academic students of the pharmacy and medical study program were collected to measure their level of perception and readiness for IPE before and after the implementation of IPE. The data were analyzed using the SPSS computer program. Result: Perception result before IPE was 4.29 (scale 1-5) and 4.49 after IPE. As for the results of readiness, 4.15 before IPE and 4.29 after IPE. There was a significant increase in students' perceptions and readiness after the implementation of IPE (P0.005). Conclusion: Most students have a good perception and readiness for IPE and there is a significant increase after IPE. Keywords: Interprofessional Relations, Professional Education, Questionnaire Design, Interdisciplinary