bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethical considerations for developing pediatric mhealth interventions for teens with socially complex needs
Authors: Bounds Dawn T. , Stiles‐Shields Colleen , Schueller Stephen M. , Odgers Candice L. , Karnik Niranjan S. 
Published: September 2022

AbstractTopicMobile Health (mHealth) stands as a potential means to better reach, assess, and intervene with teens with socially complex needs. These youth often face overlapping adversities including medical illness and a history of experiencing adverse childhood experiences (ACEs). Clinicians are faced with navigating ethical decisions when developing mHealth tools for teens who have socially complex needs. Many tools have been developed for adults from the general population. However, despite the development of thousands of mHealth interventions, developers tend to focus on designing for usability, engagement, and efficacy, with less attention on the ethical considerations of making such tools.PurposeTo safely move mHealth interventions from research into clinical practice, ethical standards must be met during the design phase. In this paper we adapt the Four Box Model (i.e., medical indications, preferences of patients, quality of life, and contextual features) to guide mHealth developers through ethical considerations when designing mHealth interventions for teens who present with a medical diagnosis and a history of ACEs.SourcesA review of language, inclusive features, data sharing, and usability is presented using both the Four Box Model and potential scenarios to guide each consideration.ConclusionsTo better support designers of mHealth tools we present a framework for evaluating applications to determine overlap with ethical design and are well suited for use in clinical practice with underserved pediatric patients.
tRNA‐derived fragment tRF‐1020 ameliorates diabetes‐induced retinal microvascular complications
Authors: Ma Cong , Du Jianling , Ma Xiang 
Published: September 2022

AbstractTransfer RNA (tRNA)‐derived fragments are the non‐coding single‐stranded RNAs involved in several physiological and pathological processes. Herein, we investigated the role of tRF‐1020, a tRNA fragment, in diabetes‐induced retinal microvascular complications. The results showed that the levels of tRF‐1020 expression were down‐regulated in diabetic retinal vessels and retinal endothelial cells following high glucose or H2O2 stress. Overexpressing tRF‐1020 led to decreased endothelial cell viability, proliferation, migration, and tube formation and alleviated retinal vascular dysfunction as shown by decreased retinal acellular capillaries, vascular leakage, and inflammation. By contrast, tRF‐1020 silencing displayed the opposite effects. tRF‐1020 regulated endothelial angiogenic functions and retinal vascular dysfunction by targeting Wnt signalling. Moreover, the levels of tRF‐1020 expression were reduced in aqueous humour and vitreous samples of the patients with diabetic retinopathy. Collectively, tRF‐1020 is a potential target for the diagnosis and treatment of diabetic retinopathy.
Neurodevelopmental delay up to the age of 4 years in infants born to women with gestational diabetes mellitus: The Japan Environment and Children's Study
Authors: Saito Yoshihiro , Kobayashi Sumitaka , Ito Sachiko , Miyashita Chihiro , Umazume Takeshi , Cho Kazutoshi , Watari Hidemichi , Ito Yoshiya , Saijo Yasuaki , Kishi Reiko ,   the Japan Environment and Children's Study group
Published: September 2022

AbstractAims/IntroductionThis study aimed to investigate the neurodevelopment of infants born to women with gestational diabetes mellitus (GDM).Materials and MethodsData from the National Birth Cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 81,705) were used. Japan uses the GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The Japanese translation of the Ages and Stages Questionnaires, third Edition, was used to assess neurodevelopment in the following domains: communication skills, gross motor skills, fine motor skills, problem‐solving ability, and personal and social skills. The survey was carried out every 6 months from the age of 6 months to 4 years (total of eight times). Generalized estimating equations were used to evaluate the association between maternal GDM and neurodevelopmental delay based on odds ratios (ORs) and 95% confidence intervals (95% CIs).ResultsNeurodevelopmental delays, particularly in problem‐solving ability, fine motor skills, and personal and social skills, were significantly higher in infants born to women with GDM than in those born to women without GDM (adjusted OR 1.24, 95% CI 1.12–1.36; adjusted OR 1.15, 95% CI 1.03–1.27; and adjusted OR 1.18, 95% CI 1.04–1.33). Furthermore, stratification showed no significant increase in the adjusted ORs (95% CIs) of girls.ConclusionsNeurodevelopment was significantly delayed up to 4 years‐of‐age among boys born to women with GDM.
Effects of diet switching from almond pollen to natural prey on predation capacity of Neoseiulus cucumeris
Authors: Yazdanpanah Shima , Fathipour Yaghoub , Riahi Elham , Zalucki Myron P. 
Published: September 2022

AbstractMonitoring the performance of a predator long‐term reared on a non‐prey diet when switches to a prey is extremely important to have a successful biological control program. In the current study, the efficacy of Neoseiulus cucumeris Oudemans long‐term reared on almond pollen during 30 generations in encountering with its natural prey, Tetranychus urticae Koch was evaluated under laboratory conditions. Every 10 generations (G1, G10, G20 and G30), the development, reproduction, population growth potential and predation capacity of the predator were determined after exposure to the natural prey, for one (S1), three (S3) or five (S5) successive generations. The results indicated that the pre‐adult duration of N. cucumeris before diet switching did not differ from those after diet switching in G1, G20 and G30. Similarly, the values of the intrinsic rate of increase (r) and finite rate of increase (λ) were not significantly affected by the diet switching in all generations tested. Furthermore, there was no significant difference in pre‐adult duration between the individuals reared on natural prey for one generation or more in all generations tested, except for G1. Continuous feeding on the prey for five generations (G1‐S5 and G30‐S5) significantly reduced the fecundity compared with those reared for three generations (G1‐S3 and G30‐S3). We found that continuous feeding on natural prey for three or five generations after different periods of feeding on almond pollen did not significantly change the most important life history traits and predation capacity. In other words, the overall performance of the mass‐reared predator remained effective after exposure to natural prey for five generations. It can be concluded that almond pollen is a good food source for the rearing of N. cucumeris because the population growth potential and reproduction of the predator remained constant during the long‐term rearing and after switching to the natural prey.
The effectiveness of auricular acupressure on pain management during labor: A systematic review and meta‐analysis of randomized controlled trials
Authors: Xu Meng‐Meng , Tian Qi , Yu Lin , Yang Shu , Liu Yan‐tong , Yu Shuang‐han , Cao Ming‐lu , Zhang Wei 
Published: September 2022

AbstractAimThis meta‐analysis aimed to systematically evaluate the effectiveness of auricular acupressure on pain management during labor.MethodsSix English and three Chinese electronic databases were comprehensively searched from inception to 6 November 2021. The PRISMA checklist was followed. The methodological quality of the included studies was assessed with the Cochrane Collaboration Bias Risk Assessment Tool. The meta‐analysis was performed using Review Manager 5.3 software. Heterogeneity between studies was calculated using I2.ResultsFive studies comprising 312 participants were included. The labor pain scores of the auricular acupressure group were significantly lower than those of the usual care group at cervix dilations of 6, 8, and 10 cm, with mean differences (95% confidence intervals) of −1.05 (−1.41, −0.69), −1.44 (−2.07, −0.82), and −1.96 (−3.30, −0.61), respectively. Auricular acupressure can thus effectively improve the labor pain perception at cervix dilations of 6, 8, and 10 cm. Moreover, auricular acupressure shortened the active phase, and had the trend of shortening the second and third stages of labor. There was no evidence that auricular acupressure had an effect on the rate of cesarean section or the 1 and 5 min Apgar scores.ConclusionEffective labor pain relief, better labor pain perception, and the lack of adverse effects support the use of auricular acupressure. More high‐quality and rigorous trials are needed to verify our findings before we can make strong recommendations.
Relationship between professional attitude and compassion among nurses
Authors: Erbil Nülüfer , Pamuk Tuğba 
Published: September 2022

AbstractBackground and AimThe aim of this study was to examine the relationship between professional attitude and compassion among nurses.Material and MethodsThe sample of the crossectional study recruited 202 nurses who accepted participation and working in a state hospital. Data were collected between 20 June 2019 and 2 August 2019 with a questionnaire form, Inventory of Professional Attitude at Occupation (IPA) and Compassion Scale. Data were collected via face‐to‐face method. Form and scales were completed by the participants. The study was reported according to the STROBE.ResultsThe mean IPA was 134.57 ± 15.43. The mean score of the Compassion Scale was 73.89 ± 11.54. The mean scores of the Compassion Scale's sub‐dimensions were 16.17 ± 3.22 for kindness, 8.62 ± 3.44 for indifference, 15.45 ± 3.17 for common humanity, 9.02 ± 3.46 for separation, 15.95 ± 3.00 for mindfulness, 8.67 ± 3.44 for disengagement. There were positive correlations between kindness (r = .356), common humanity (r = .214), mindfulness (r = .297) subscales and there were negative correlations between indifference (r = −.441), separation (r = −.411) and disengagement (r = −.415) subscales and the Inventory of IPA. There was a negative correlation between IPA and total Compassion Scale scores (r = −.140). IPA scores were significantly different according to sex, age, working duration, weekly working time, satisfied with colleague relationships. Compassion scores were significantly different for weekly working time, satisfaction with colleague relationships, suitability of the nursing profession and working in emergency and outpatient clinics (p < .05).ConclusionAs nurses' professional attitude scores increased, kindness, common humanity and mindfulness subscales scores increased, while indifference, separation and disengagement subscales scores of the compassion scale decreased.Relevance to clinical practiceIncreasing the awareness about professional attitude and compassion in nursing should start with undergraduate education of nurses, and it is recommended to organise in‐service training to develop professional attitudes and compassion in occupational life and to research patient perspectives about compassion.
Broad and narrow environmental and genetic sources of personality differences: An extended twin family study
Authors: Kandler Christian , Zapko‐Willmes Alexandra , Rauthmann John F. 
Published: September 2022

AbstractObjectiveSeveral personality theories distinguish between rather genetically rooted, universal dispositional traits (DTs) and rather environmentally shaped, more contextualized characteristic adaptations (CAs). However, no study so far has compared different measures of theoretically postulated DTs and CAs regarding their environmental and genetic components while considering differences in measurement abstraction and reliability. This study aims to bridge this gap by testing the assumed differences in the sensitivity to environmental influences based on representative sets of DTs (Big Five and HEXACO domains and facets) and CAs (goals, interests, value priorities, religiousness, and self‐schemas).MethodUsing intra‐class correlations and running extended twin family and spouses‐of‐twins model analyses, we analyzed a large data set (N = 1967) encompassing 636 twin pairs, 787 parent‐offspring dyads, and 325 spouses/partners.ResultsFindings consistently support lower environmentality of DTs compared to CAs. On average, more than half of reliable variance in DTs was genetic, whereas the reverse was found for CAs. Larger environmental components in CAs were primarily attributable to larger individual‐specific effects (beyond error of measurement) and factors shared by spouses.ConclusionsFindings are discussed against the background of the definitional distinction between DTs and CAs and the value of extended twin family data.
Identification of Bacillus species causing bacterial leaf spot of peach in China
Authors: Jin Shi , Wang Na , Zhou Zongshan , Ji Zhirui , Zhang Junxiang 
Published: September 2022

AbstractPeach (Prunus persica L.) is an economically important fruit and is cultivated widely in the world. Bacterial leaf spot (BLS) is a major disease limiting the yield of peach in most peach‐producing areas worldwide. To identify the pathogen causing bacterial leaf spot, evaluate its pathogenicity, and explore its host range, the diseased leaves were collected. Phylogenetic analysis of the partial 16S rRNA genes showed that the five isolates belong to the Bacillus cereus species complex. Three of the five isolates were identified as B. cereus, with the remaining isolates being B. thuringiensis and B. pacificus, based on multilocus sequence analysis (16S rDNA, adk, ccpA, ftsA, glpT, pyrE, recF, and sucC) and biochemical characteristics. All five isolates were pathogenic on Prunus persica as well as on Cerasus pseudocerasus, but none of the isolates was pathogenic on C. humilis, plum (Prunus salicina), or Armeniaca vulgaris. To our knowledge, this is the first report on the occurrence of B. cereus species complex as causal agents of BLS of peach, which will benefit the development of future control measures.
Using phylogenomics to untangle the taxonomic incongruence of yellow‐flowered Camellia species (Theaceae) in China
Authors: Wei Su‐Juan , Liufu Yong‐Qing , Zheng He‐Wen , Chen Hai‐Ling , Lai Yan‐Chi , Liu Yan , Ye Quan‐Qing , Tang Shao‐Qing 
Published: September 2022

AbstractAll yellow Camellia plants in China are threatened, but their classification is contentious. Here, we performed a phylogenetic reconstruction based on nuclear double‐digest restriction site‐associated DNA sequencing (ddRAD), transcriptomes, nuclear ribosomal internal transcribed spacer (nrITS), and the small single‐copy region of the chloroplast genome, in combination with morphological evidence to help resolve taxonomic ambiguity of those rare and threatened species. Conflicting relationships were derived from nuclear and chloroplast sequences. The strong hybridization/introgression signal detected suggests reticulate evolution mainly caused this discordance pattern. The nuclear‐ddRAD and RNA‐seq phylogenies fit better to the yellow camellias' morphology, providing a clear resolution for inferring their relationships in China. Based on present phylogenetic analyses and morphological characters, we propose these taxonomic suggestions: (i) Camellia petelotii and Camellia nitidissima are distinct species; (ii) Camellia ptilosperma, Camellia longruiensis, Camellia longgangensis, and C. longgangensis var. grandis are conspecific with Camellia flavida; (iii) Camellia multipetala and C. longgangensis var. patens are synonyms of Camellia quinqueloculosa, and C. quinqueloculosa should be recognized as an independent species; (iv) Camellia wumingensis should be formally recognized as an independent species; (v) Camellia longzhouensis is a synonym of Camellia chrysanthoides; (vi) Camellia xiashiensis and Camellia parvipetala should be treated as synonyms of Camellia micrantha; (vii) Camellia achrysantha is a good species; (viii) Camellia tunghinensis is an independent species; (ix) species status of Camellia huana is well‐supported; and (x) Camellia pingguoensis var. terminals should be correctly identified to species level as Camellia terminalis. These results provide the basis for the recognition 20 yellow Camellia species in China.
Can fluconazole be used for inpatient re‐treatment of coccidioidomycosis among patients with past fluconazole exposures?
Authors: Magdalany Amy N. , Nailor Michael D. , Gonzalez Omar , Goodlet Kellie J. 
Published: September 2022

AbstractBackgroundCoccidioides spp. may cause significant disease requiring hospitalisation, but optimal antifungal therapy among inpatients following outpatient fluconazole exposures is unknown.ObjectivesThe objective of this study is to describe the effectiveness of fluconazole among patients hospitalised for coccidioidomycosis despite recent outpatient fluconazole treatment.Patients/MethodsPatients were admitted to an academic medical center in Phoenix, Arizona from 1 January 2013 through 31 December 2020 for coccidioidomycosis following at least 30 days of outpatient treatment and re‐initiation of fluconazole upon admission. The primary outcome was the proportion of patients with an improved response per the change in the modified Mycosis Study Group (MSG) score (a composite of symptoms, serology and radiographic findings) and clinician impressions.ResultsSixty‐seven patients were included, with most (54%) admitted to the intensive care unit. Meningitis was the most common infectious presentation (55%), 17 patients (25%) had multiple infection sites, and 23 (34%) were culture‐positive for Coccidioides. Upon admission, the median (IQR) MSG score was 11 (9–14), which dropped to 4 (1–7) at end of therapy or last follow‐up. Overall, after initiation of fluconazole therapy at a median daily dose of 800 mg, 48 patients (72%) improved in overall status, 10 (15%) showed stable disease and 9 (13%) were unresponsive. Improved response rates were high across all infection sites, including meningitis (68%) and bone infection (71%). There was no significant difference in response rates between patients with and without reported outpatient fluconazole nonadherence.ConclusionsThe majority of patients admitted to the hospital for coccidioidomycosis appeared responsive to fluconazole therapy despite past outpatient exposures.
Natural diversity uncoversP5CS1regulation and its role in drought stress tolerance and yield sustainability in barley
Authors: Shrestha Asis , Fendel Alexander , Nguyen Thuy H. , Adebabay Anteneh , Kullik Annika Stina , Benndorf Jan , Leon Jens , Naz Ali A. 
Published: September 2022

AbstractProline accumulation is one of the major responses of plants to many abiotic stresses. However, the significance of proline accumulation for drought stress tolerance remains enigmatic in crop plants. First, we examined the natural variation of the pyrolline‐5‐carboxylate synthase (P5CS1) among 49 barley genotypes. Allele mining identified a previously unknown allelic series that showed polymorphisms at 42cis‐elements across theP5CS1promoter. Selected haplotypes had quantitative variation inP5CS1gene expression and proline accumulation, putatively influenced by both abscisic acid‐dependent and independent pathways under drought stress. Next, we introgressed theP5CS1allele from a high proline accumulating wild barley accession ISR42‐8 into cultivar Scarlett developing a near‐isogenic line (NIL‐143). NIL‐143 accumulated higher proline concentrations than Scarlett under drought stress at seedling and reproductive stages. Under drought stress, NIL‐143 showed less pigment damage, sustained photosynthetic health, and higher drought stress recovery compared to Scarlett. Further, the drought‐induced damage to yield‐related traits, mainly thousand‐grain weight, was lower in NIL‐143 compared with Scarlett in field conditions. Our data uncovered new variants of theP5CS1promoter and the significance of the increased proline accumulation regulated by theP5CS1allele of ISR42‐8 in drought stress tolerance and yield stability in barley.
Impact of multiorgan and kidney–pancreas allocation policies on pediatric kidney‐alone transplant candidates in the United States
Authors: Engen Rachel , Shepherd Danielle , Bradford Miranda C. , Foutz Julia , Bartosh Sharon M. , Smith Jodi M. 
Published: September 2022

AbstractBackgroundThe United States organ allocation policies prioritize kidney–pancreas and other multiorgan candidates above pediatric kidney‐alone candidates, but the effects of these policies are unclear.MethodsWe used OPTN data to describe trends in multiorgan and kidney–pancreas transplantation and identify 377 next‐sequential pediatric kidney‐alone candidates between 4/1/2015 and 10/31/2019 for individual‐level analysis.ResultsEleven percent of all kidneys were allocated as part of a multiorgan or kidney–pancreas transplant and 6% of pediatric kidney candidates were impacted. Pediatric next‐sequential candidates accrued a median of 118 days (IQR 97–135 days) of additional wait time, and this was significantly longer for children who were Hispanic (p = .02), blood type B or O (p = .01), or had a cPRA ≥20% (p < .01). Eight pediatric next‐sequential candidates (2%) were removed from the waitlist due to death or “too sick to transplant.” 63% were transplanted with a kidney with a higher KDPI than the original multiorgan match (p < .01). Donor service areas with higher volumes of kidney–pancreas transplants had significantly longer additional wait times for pediatric next‐sequential candidates (p = .01).ConclusionsCurrent allocation policy results in longer waiting times and higher KDPI kidneys for pediatric kidney candidates. As multiorgan transplant volume is increasing, further consideration of allocation policy is necessary to maximize equality and utility.
Partial dollarization and financial frictions in emerging economies
Authors: Gabriel Vasco J. , Levine Paul , Yang Bo 
Published: September 2022

AbstractHow do financial frictions affect macroeconomic volatility and monetary policy in emerging market economies? This article assesses the empirical relevance of such frictions by estimating a two‐bloc emerging market/rest‐of‐the‐world model containing two key features of emerging economies: partial transaction and liability dollarization, and financial frictions where capital financing is partially or totally in foreign currency. Our estimation employs the “one‐step approach” which allows us to be “agnostic” regarding nonstationarity in the data and simultaneously estimate structural and trend parameters. Using data for Peru and the US, we find substantial empirical support for both the financial accelerator and partial dollarization mechanisms. The data fit of the baseline model improves with the addition of each of these frictions, exogenous shocks are significantly amplified in their presence and our preferred model captures several important stylized facts of a small emerging open economy.