bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complicações relacionadas ao cateterismo intravenoso perifério em adultos em um hospital público
Authors: Schneider Santos Mariana Conceição , De Assis Sales Ana Paula , Rezende de Pádua Del Corona Arminda , Moita Garcia Kawakame Patricia , Pereira Frota Oleci 
Published: March 2022

Investigar a ocorrência de incidentes na prática da prática das venopunções periféricas em participantes adultos em um hospital de ensino. Método: Estudo quantitativo, prospectivo, relativo às complicações de venopunções. Os participantes foram acompanhados desde o início da punção venosa periférica até o 4°dia. Resultados: Foram acompanhados 75 punções, destas as complicações identificadas são: infiltração grau I, 9 (12%); flebite grau II, 7 (9,3%); obstrução 6 (8%) e hematoma 2 (2,6%). A maior parte dos acessos permaneceu período inferior ou igual há 72 horas. Conclusão: A complicação mais citada em estudos é a flebite, no entanto, neste predominou os casos de infiltração. A segurança do paciente foi um problema identificado nas unidades onde se procederam a coleta de dados. O estudo é útil para incentivo aos profissionais sobre as boas práticas. Sugere-se aperfeiçoamento da prática de educação permanente dos funcionários.

Palavras-chave: Cateterismo periférico. Infusões intravenosas. Enfermagem. Enfermagem assistencial. Segurança do paciente
The Ottawa 3DY Predicts Mortality in a Prospective Cohort Study
Authors: St John Philip Donald , Molnar Frank Joseph 
Published: March 2022

Background
The Ottawa 3DY (O3DY) is a simple measure of cognition.
Objectives
1) To determine if the O3DY predicts mortality; and 2) To compare the discrimination of the O3DY to the Mini-Mental State Examination (MMSE) and Modified MMSE (3MS).
Methods
Analyses of a population based cohort study of 1,751 participants aged 65+; conducted in 1991/2 with follow-up over five years. The O3DY, age, sex, education, comorbid conditions, the MMSE, and the 3MS were measured: 4.5% of the participants had missing data for the O3DY; 42.8% were considered as positive (one or more errors), and 52.7% were considered as negative (no errors). Logistic regression models were constructed with the outcome of death at time 2. A Receiver Operator Curve (ROC) was constructed and the Area Under the ROC (AUROC) was calculated using a c-statistic.
Results
The unadjusted odds ratio (OR) and 95% confidence interval (CI) for mortality was 1.96 (1.56, 2.47); and the adjusted OR was 1.33 (1.02, 1.72). The AUROC was 0.66 for the 3MS, 0.65 for the MMSE, and 0.60 for the O3DY.
Conclusions
The O3DY predicts mortality over a long time frame, although the discrimination is less than that of longer measures of cognition.
Program Evaluation of SeeMe™: Understanding Frailty Together
Authors: Liu Andrea , Sinden Danielle , Plant Jennifer , Norman Melissa , Acosta Daniela , Hsu Amy , Robert Benoît 
Published: March 2022

Background
Perley Health has implemented SeeMe™: Understanding frailty together (www.perleyhealth.ca), a comprehensive approach to care that integrates the assessment and management of frailty, with an emphasis on goals of care planning.
Methods
Program evaluation over the first year of SeeMe™ used a mixed-methods approach involving quantitative data from surveys, goals of care preferences, hospital transfers, and qualitative data from interviews.
Results
The SeeMe™ training is an effective way to educate nurses and physicians in long-term care about frailty. For residents with documented care preferences prior to SeeMe™, there was a 15% reduction in the number of residents who preferred to be transferred to hospital post-SeeMe™ implementation. There was no significant decrease in hospital transfers during the first year the program was introduced.
Conclusion
After the roll-out of SeeMe™, nurses, physicians, and families reported high satisfaction with the program, and nurses reported an increase in knowledge and confidence. There was also a reduction in the number of residents and families selecting to transfer to hospital. This suggests that the education from SeeMe™ influenced residents and families to choose less invasive interventions in the context of frailty and quality of life goals.
Safety and Tolerability of Fesoterodine in Older Adult Patients with Overactive Bladder
Authors: Heesakkers John , Te Dorsthorst Manon , Wagg Adrian 
Published: March 2022

Background
Older patients (> 65 yr) suffering from overactive bladder (OAB) are more likely to have functional impairment and comorbidity than those without OAB. This article reviews available published studies and discusses how fesoterodine might meet the specific needs of the older OAB patient.
Methods
A comprehensive literature search was undertaken in order to evaluate fesoterodine safety in older OAB patients.
Results
Fesoterodine offers flexible dosing, allowing the clinician to balance risk and benefits according to the symptoms and preferences of the patient. Its balanced affinity for M2 and M3 muscarinic receptors may lead to its benefit on OAB symptoms. Its active metabolite is a P-gp substrate that is actively transported from the central nervous system (CNS), potentially avoiding adverse CNS effects. Fesoterodine can be used in mild or moderate hepatic or renal insufficiency and no dose adjustment is routinely required. Fesoterodine’s benefit has been demonstrated in multiple clinical trials in older and medically vulnerable patients. Fesoterodine was rated as “beneficial” in the LUTS-FORTA classification due to its efficiency and tolerability in older patients.
Conclusion
Here, the use of fesoterodine in older and vulnerable patients is summarized given the need to approach pharmacotherapy for OAB differently in older adults.
Millennials’ Travel Behavior in Small Island Destination: The Overview of Gili Trawangan, Indonesia
Authors: Demolingo Ramang H. , Dewi Liliana , Karyatun Subur , Wiweka Kadek , Adnyana Putu Pramania , Prasetya Andhika 
Published: March 2022

Aims: The purpose of this study is to examine the travel behavior of millennial generation tourists in Gili Trawangan at the pre-, during-, and post-travel stages. This research also looks into the viability of Gili Trawangan as a small island destination.
Methodology: This study employs a qualitative descriptive approach, with data gathered through questionnaires, in-depth interviews, and literary techniques. The questionnaire was distributed in May and June, with 100 millennial generation tourists on Gili Trawangan, both international and domestic, serving as respondents.
Result: According to the findings of this study, Gili Trawangan is one of the small island destinations that offers tourism-related products such as water tourism attraction, accessibility, ancillary service, and tourist activity. On the demand side, millennial tourists who visit this island are productive generations who come from various large cities in Indonesia or abroad. They are considered a digital generation due to their reliance on smartphones and social media in all aspects of daily life, including work, entertainment, and travel. As a result, millennial tourists' travel decisions are heavily influenced by digital information such as social media status and digital advertisements. Although there is almost no significant difference in the travel behavior of the two types of tourists in general. However, there are some basic differences caused by socio-cultural differences and economic conditions.
Implication/Applications: This research is useful as a reference for tourism industry stakeholders on the island of Gili Trawangan to comprehensively understand the characteristics of millennial generation tourists. Theoretically, the results of this study can also enrich the existing information related to the behavior of millennial tourists, especially those who visit small island destinations.
The Originality of the Study: The small sample size and short questionnaire distribution period were two of the study's limitations. As a result, future research will be able to examine other island tourist destinations with better numbers and an even distribution of vacation sessions.
Correlation of Diet Regimen in Manifestation of Skin Diseases: A Survey
Authors: Kapurkar Shivani , Ghumde Pooja , Chalakh Sonali 
Published: March 2022

Background: Ahara plays main role in the life of every individual. Dietary regimen as always been placed first while discussing the causes for skin diseases. The normal integrity and the immunological role of skin is maintained by nutritional, biochemical and metabolic aspects of diet. Maintaining dietary lifestyle strictly prevents not only skin diseases but also various systemic diseases. So to assess the type of diet and dietary regime in the patient of skin diseases this study has been evaluated.
Aim: Assessing rule of diet-daily regimen in skin diseases of modern era with Ayurveda perspective.
Methods: 100 Patients visiting Kayachikitsa OPD within the duration of 6 months.
Results: It is observed that Aharja hetu and skin diseases are interlinked with each other which disturb psychological health, which ultimately gets affected to sleep pattern. The same subjective we came through while drawing the resultants of the present survey study, in certain aspect that, Mixed diet (70%), Oily and Spicy food (43%), Curd (42%), Tila taila (41%), Madhur (20%), Tea (28%), Snehadravya and Ushnadravya sevan (17%), Ksudha- Bad (38%).
Conclusion: Aharaj hetu are responsible for skin disease due, to habituation with various food entities, leading to rasa raktadi dhatu dushti & its precursor dhatu as well , also it should be taken in consideration that, dhatu are been vitiated by dushit avastha of dosha, which ultimately causes of skin disease.
Effect of Initial Antibiotic Therapy in Patients with Blunt Abdominal Trauma
Authors: Joshi Disha R. , Kanase V. V. , Katkar Akash 
Published: March 2022

Background: Practising the use of antibiotics in emergency surgeries drastically reduces the incidence of post-operative systemic and surgical site infections. There are very few articles about the details of use of antibiotics in abdominal trauma. We studied the effect of preliminary drugs therapy against bacteria in patients with abdominal trauma.
Methods: From Ma y 2020 to May 2021, we looked back and surveyed the medical files of patients with abdominal trauma in our institution, Krishna institute of medical sciences deemed to be university, Karad. Blunt and piercing abdominal injuries were included in our study
Results: Data of the 432 patients were accumulated. Antibiotic was initiated in 96.4% of penetrating injury and 79.7% with blunt injury. Initial antibiotics therapy was provided to 78.2% of patients with solid organ injury and 97.5% with hollow viscus injury. On an average of 6 days, antibiotics were given in solid organ injuries, 6.2 days in hollow viscus. Infection within 2 weeks of admission occurred in 50 cases. Infection linked severity of injury, surgery performed and blood transfused. Time for which the antibiotic was given did not affect the rate of infection.
Conclusion: It was inferred that the antibiotics were used in massive numbers (84.2%) and for prolonged time (6.2 days) in these patients in Karad.
Effect of the simulated half leaf width of a multileaf collimator on volumetric modulated arc therapy plan quality in hippocampal avoidance whole‐brain radiotherapy
Authors: Li Ming‐Hsien , Chen Li‐Jhen , Chang Chih‐Chieh , Tsai Jo‐Ting , Lin Jang‐Chun 
Published: March 2022

AbstractPurposeWhole‐brain radiotherapy (WBRT) is commonly used in patients with multiple brain metastases. Compared with conventional WBRT, hippocampal avoidance WBRT (HA‐WBRT) more favorably preserves cognitive function and the quality of life. The hippocampal volume is considerably small (approximately 3.3 cm3). Therefore, downsizing the leaf width of a multileaf collimator (MLC) may provide higher spatial resolution and better plan quality. Volumetric modulated arc therapy (VMAT) could simulate the half MLC leaf width through couch shifting between arcs. This study investigated changes in VMAT quality for HA‐WBRT with a simulated fine MLC leaf width.MethodsWe included 18 patients with brain metastasis. All target and avoidance structures were contoured by an experienced radiation oncologist. The prescribed dose was 30 Gy in 10 fractions. For each patient, three different treatment plans were generated for comparison: VMAT with couch‐shift, VMAT without couch‐shift, and TomoTherapy. All treatment plans fulfilled Radiation Therapy Oncology Group (RTOG) 0933 criteria for HA‐WBRT. The Wilcoxon paired signed‐rank test was used to compare different treatment plans.ResultsVMAT with couch‐shift had the better average conformity index (0.823) with statistically significant difference compared to VMAT without couch‐shift (0.810). VMAT with couch‐shift (0.219) had a more favorable average homogeneity index (HI) than did VMAT without couch‐shift (0.230), although the difference was not significant. TomoTherapy had an optimal average HI of 0.070. In terms of the hippocampus, all three treatment plans met the RTOG 0933 criteria. VMAT with couch‐shift had a lower average Dmax (15.2 Gy) than did VMAT without couch‐shift (15.3 Gy, p = 0.071) and TomoTherapy (15.5 Gy, p = 0.133). The average D100% of hippocampus was the same for both VMAT with and without couch‐shift (8.5 Gy); however, TomoTherapy had a lower average D100% value of 7.9 Gy. The treatment delivery time was similar between VMAT with and without couch‐shift (average, 375.0 and 369.6 s, respectively). TomoTherapy required a long average delivery time of 1489.9 s.ConclusionThe plan quality of VMAT for HA‐WBRT was improved by using the couch‐shift technique to simulate the half MLC leaf width. However, the improvement was not statistically significant except conformity index. The downsizing effect decreased with the use of the sophisticated grade of VMAT. TomoTherapy offered superior plan quality but required the longest delivery time.
Benchmarking the proteomic profile of animal models of mesial temporal epilepsy
Authors: Canto Amanda M. , Godoi Alexandre B. , Matos Alexandre H. B. , Geraldis Jaqueline C. , Rogerio Fabio , Alvim Marina K. M. , Yasuda Clarissa L. , Ghizoni Enrico , Tedeschi Helder , Veiga Diogo F. T. , Henning Barbara , Souza Welliton , Rocha Cristiane S. , Vieira André S. , Dias Elayne V. , Carvalho Benilton S. , Gilioli Rovilson , Arul Albert B. , Robinson Renã A. S. , Cendes Fernando , Lopes‐Cendes Iscia 
Published: March 2022

AbstractObjectivesWe compared the proteomic signatures of the hippocampal lesion induced in three different animal models of mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS): the systemic pilocarpine model (PILO), the intracerebroventricular kainic acid model (KA), and the perforant pathway stimulation model (PPS).MethodsWe used shotgun proteomics to analyze the proteomes and find enriched biological pathways of the dorsal and ventral dentate gyrus (DG) isolated from the hippocampi of the three animal models. We also compared the proteomes obtained in the animal models to that from the DG of patients with pharmacoresistant MTLE+HS.ResultsWe found that each animal model presents specific profiles of proteomic changes. The PILO model showed responses predominantly related to neuronal excitatory imbalance. The KA model revealed alterations mainly in synaptic activity. The PPS model displayed abnormalities in metabolism and oxidative stress. We also identified common biological pathways enriched in all three models, such as inflammation and immune response, which were also observed in tissue from patients. However, none of the models could recapitulate the profile of molecular changes observed in tissue from patients.SignificanceOur results indicate that each model has its own set of biological responses leading to epilepsy. Thus, it seems that only using a combination of the three models may one replicate more closely the mechanisms underlying MTLE+HS as seen in patients.
Translation Reprogramming as a Novel Therapeutic Target in MAFLD
Authors: Metwally Mayada , Berg Thomas , Tsochatzis Emmanuel A. , Eslam Mohammed 
Published: March 2022

AbstractApproved pharmacotherapies for metabolic‐dysfunction‐associated fatty liver disease (MAFLD) are lacking. Novel approaches and therapeutic targets that are likely to translate to clinical benefit are required. Targeting components of the translation machinery hold promise as a novel therapeutic approach that can overcome the well‐known disease heterogeneity, as dysregulation of mRNA translation is a common feature independent of the MAFLD drivers. In this perspective, recent advances in understanding the role of mRNA translation in MAFLD are discussed, with a particular focus on the potential implications and challenges to “translate” these findings to the clinic, and an overview of similar recent efforts in other diseases is provided.
Targeting the Microenvironment of Vulnerable Atherosclerotic Plaques: An Emerging Diagnosis and Therapy Strategy for Atherosclerosis
Authors: Zhang Shuai , Liu Yang , Cao Yue , Zhang Songtao , Sun Jian , Wang Yinghui , Song Shuyan , Zhang Hongjie 
Published: March 2022

AbstractAtherosclerosis is considered one of the primary causes of cardiovascular diseases (CVDs). Unpredictable rupture of the vulnerable atherosclerotic plaques triggers adverse cardiovascular events such as acute myocardial syndrome and even sudden cardiac death. Therefore, assessing the vulnerability of atherosclerotic plaques and early intervention are of significance in reducing CVD mortality. Nanomedicine possesses tremendous advantages in achieving the integration of the diagnosis and therapy of atherosclerotic plaques because of its magnetic, optical, thermal, and catalytic properties. Based on the pathological characteristics of vulnerable plaques, stimuli‐responsive nanoplatforms and surface‐functionalized nanoagents are designed and have drawn great attention for accomplishing the precise imaging and treatment of vulnerable atherosclerotic plaques due to their superior properties, such as high bioavailability, lesion‐targeting specificity, on‐demand cargo release, and low off‐target damage. Here, the characteristics of vulnerable plaques are generalized, and some targeted strategies for boosting the accuracy of plaque vulnerability evaluation by imaging and the efficacy of plaque stabilization therapy (including antioxidant therapy, macrophage depletion therapy, regulation of lipid metabolism therapy, anti‐inflammation therapy, etc.) are systematically summarized. In addition, existing challenges and prospects in this field are discussed, and it is believed to provide new thinking for the diagnosis and treatment of CVDs in the near future.
Farming‐Inspired Continuous Fabrication of Grating Flexible Transparent Film with Anisotropic Conductivity
Authors: Wei Haokun , Zhang Yuanbo , Zhang Xinyu , Feng Bingqiang , Zhou Bing , Zhao Yanjun , Zheng Guoqiang , Dai Kun , Liu Chuntai , Shen Changyu 
Published: March 2022

AbstractFlexible transparent conductive films (FTCFs) are critically important for the emerging flexible electronic devices. To this end, FTCFs with conductive gratings have drawn more interests in the past decades. However, there are great challenges to fabricate such FTCFs containing conductive gratings in a facile way. Borrowing the idea from traditional farming, a homemade roll‐to‐roll plowing technique combined with blade coating is proposed to fabricate silver grating FTCFs with anisotropic conductivity in a continuous, cost‐effective, and environmental friendly way. The as‐prepared FTCFs exhibit satisfied optical and electrical properties (i.e., transmittance is 78.2% and sheet resistance is 3.1 Ω □–1). After coated with thin polyvinyl butyral layer through hot‐pressing, it shows a higher transmittance of 84.2% and remarkable mechanical flexibility. Based on the FTCFs with anisotropic conductivity, flexible transparent heater and capacitive keyboard are successfully fabricated. Furthermore, based on such flexible capacitive keyboard, smart wireless controlled human–machine interface system is developed to wirelessly control tablet personal computer working and quadrotor flying. This study provides a promising strategy to fabricate high‐performance FTCFs with anisotropic conductivity via a continuous, cost‐effective, and environmental friendly way.
Hybrid Halide Perovskite‐Based Near‐Infrared Photodetectors and Imaging Arrays
Authors: Mei Luyao , Huang Runfeng , Shen Chaorong , Hu Jianguo , Wang Pu , Xu Zhengji , Huang Zhanfeng , Zhu Lu 
Published: March 2022

AbstractHybrid halide perovskites have been demonstrated to be prospective materials in optoelectronic devices due to their outstanding photoelectric properties and facile manufacturability by low‐cost and fast solution‐processed methods. Particularly, to meet increasingly potential applications in near‐infrared (NIR) detection and imaging, perovskites have been introduced and explored their roles, some of which achieve the comparable performance with traditional silicon counterparts. Here, the recent advancements of hybrid halide perovskite‐based NIR photodetectors and imaging arrays in terms of perovskite formation, device structures, working mechanisms, and device performances are reviewed. Pb perovskite‐based devices either employ sub‐bandgap absorption and intraband transition, or incorporate with narrow‐bandgap semiconductors to achieve NIR detection, which could reach the spectral response onset at 2.6 µm wavelength. Sn perovskite‐based devices employ the strategies of template‐assisted engineering and reducing additives to inhibit the oxidation of Sn2+ states for efficient detection. SnPb mixed perovskite devices employ compositional engineering, passivation strategies, crystallization tuning, and encapsulation to achieve efficient and long shelf‐life photodetectors with an external quantum efficiency of 70% at 940 nm wavelength. Finally, potential prospects are proposed, including spectral response extension, pixel integration, flexible devices, and stability, to advance perovskite‐based NIR detection and imaging toward commercial applications.
Tuning the Exchange Bias Effect in 2D van der Waals Ferro‐/Antiferromagnetic Fe3GeTe2/CrOCl Heterostructures
Authors: Zhang Tianle , Zhang Yujun , Huang Mingyuan , Li Bo , Sun Yinghui , Qu Zhe , Duan Xidong , Jiang Chengbao , Yang Shengxue 
Published: March 2022

AbstractThe exchange bias effect is extremely expected in 2D van der Waals (vdW) ferromagnetic (FM)/antiferromagnetic (AFM) heterostructures due to the high‐quality interface. CrOCl possesses strong magnetic anisotropy at 2D limit, and is an ideal antiferromagnet for constructing FM/AFM heterostructures to explore the exchange bias effect. Here, the exchange bias effect in Fe3GeTe2 (FGT)/CrOCl heterostructures through both anomalous Hall effect (AHE) and reflective magnetic circular dichroism (RMCD) measurements is studied. In the AHE measurements, the exchange bias field (HEB) at 3 K exhibits a distinct increase from ≈150 Oe to ≈450 Oe after air exposure, and such variation is attributed to the formation of an oxidized layer in FGT by analyzing the cross‐sectional microstructure. The HEB is successfully tuned by changing the FGT/CrOCl thickness and the cooling field. Furthermore, a larger HEB of ≈750 Oe at 1.7 K in FGT/CrOCl heterostructure through RMCD measurements is observed, and it is proposed that the larger HEB in RMCD measurements is related to the distribution of uncompensated spins at the interface. This work reveals several intriguing phenomena of the exchange bias effect in 2D vdW magnetic systems, which paves the way for the study of related spintronic devices.