bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute right heart failure in Waldenström macroglobulinemia: A case report
Authors: Memis Hayat , Balinisteanu Anca Elena , Gaman Mihaela , Mihalcea Diana , Vinereanu Dragos 
Published: July 2022

Abstract
Waldenström macroglobulinemia (WM) is a low-grade B-cell clonal disorder with lymphoplasmacytic bone marrow involvement and monoclonal immunoglobulin M (IgM) with poor prognosis. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy and hyperviscosity. We report the case of a 42-year-old male who presented with unexplained weight loss. The diagnosis of WM was established after morphological and immunohistochemical examination of the patient's bone marrow along with an elevated serum IgM level. He started chemotherapy with cyclophosphamide, bortezomib, dexamethasone and, four months later, rituximab was added. Five months later the patient presented with relapse of the hematological disease, hyperviscosity syndrome and acute right heart failure. Echocardiography showed a dilated right ventricle with decreased global systolic function and severe systolic pulmonary artery pressure, with normal left cardiac function and volumes. Despite maximal medical therapy, the patient died in day six of hospitalization. This case is distinguished by the rapidly evolving rare haematological cancer despite optimal chemotherapy and a multidisciplinary approach associated with chemotherapy-related late right heart dysfunction in a young man, without any cardiovascular risk factors or previous myocardial disease.
Sometimes Late Is Better Than Never: Implantation of a Cardioverter Defibrillator Years after an Acute Myocardial Infarction —Case Report
Authors: Zamfirescu Maria , Ștefan Miruna Florina , Vintila Vlad Damian , Magda Stefania Lucia 
Published: July 2022

Abstract
Sustained ventricular arrhythmias that occur early post-myocardial infarction (MI) are generally considered epiphenomena of the MI and are not consistently associated with long-term prognosis. The lack of association with long-term prognosis is more clearly established for early ventricular fibrillation (VF) and polymorphic ventricular tachycardia (PVT). Sustained monomorphic ventricular tachycardia (SMVT), even when it occurs early, however, may reflect a permanent arrhythmic substrate1. Patients with COVID-19 have a high risk of thromboembolic events, and the virus has also been shown to have extensive effects on the cardiovascular system2,3,4. A 62-year-old woman, recently hospitalized for COVID-19 pneumonia, was brought to the emergency department with pulseless SMVT having been successfully resuscitated in the prehospital setting. The patient has a history of an old MI treated with thrombolysis and percutaneous coronary intervention (PCI) that was complicated with early SMVT, but with preserved left ventricular function and without heart failure. The patient underwent implantation of a cardioverter defibrillator (ICD). During the hospitalization, she developed dyspnea and was diagnosed with minor pulmonary embolism. It may be appropriate to consider early SMVT as a predictor of adverse late outcomes that would necessitate rigorous follow-up and maybe an early invasive primary prevention strategy. This case also reflects the possibility of long-term cardiac involvement and increased thromboembolic risk in patients recovering from COVID-19.
Keefektifan Penggunaan Media Pembelajaran Berbasis Game Edukasi Quizizz Terhadap Hasil Belajar Teknologi Perkantoran Siswa Kelas X SMK Ketintang Surabaya
Authors: Citra Cahyani Amildah , Rosy Brillian 
Published: July 2022

This research aims to determine the effectiveness of the effectiveness of learning media based educational game quizizz on student outcomes office technology grade X SMK Ketintang Surabaya. This type of research is using quasi experimental design. The circuit was conducted on all class X OTKP 2 students as a control class and X OTKP 3 as an experimental class. Analytical techniques use homogeneity test, normality test, hypothesis test and gain score test. The results of the study expressed the Posttest value obtained by t-test of 2.154 with a signification of 0.036 and a value of 2.002 with a level of significance 0.005 which means signification (0.036) < 0.05 and t-test (2.154) > ttable (2.002).The result of Gain Score the Pretest and Posttest value is 3,212 with a signication 0,002 and the value ttable is 2,002 with signification 0,05. So it can be concluded that the use of learning media based on Quizizz educational Game effectively improve student learning outcomes on the subject of office technology class X OTKP in SMK Ketintang Surabaya.
Potency of Bioactive Compounds in Indramayu Mango Peel Waste to Inhibit ACE2
Authors: Luthfia Mustika , Eryandini Assifah , Geraldi Deki , Narita Chelsy , Jannah Choirunnisa Miftahul , Ambarsari Laksmi 
Published: July 2022

According to reports, mango peel contains bioactive compounds—especially phenolic—threefold higher than the flesh. This issue underlies the research that aims to identify bioactive compounds from Indramayu mango peel which have the potential as ACE2 inhibitors. The study was initiated by extracting mango peel simplicia using aquadest, then carried out with phytochemical screening, and identification of compound content by LC-MS. The extraction obtained 21.3% of yield. The results of phytochemical screening showed that secondary metabolites in the form of alkaloids, flavonoids, saponins, and tannins were identified in the mango peel. At the same time, the LC-MS fragmentation results obtained 40 compounds based on the largest sample area. The result from fragmentation were tested for Lipinski bioavailability prediction and ADMET test and obtained 10 potential compounds. Molecular docking was performed on the ACE2 receptor with 10 sample ligands and 1 comparison ligand using YASARA Structure. All of the sample ligands (from Lipinski and ADMET test) showed higher free energies than comparison ligand, chloroquine. Mangiferin is a typical mango compound identified in LC-MS, had inhibitor activity against ACE2. Two-dimensional visualization using Discovery Studio showed mangiferin interaction with the receptor via hydrogen bond, hydrogen carbon bond and phi-anion interactions at three amino acid residues (Thr371, Glu375, Glu402) on the active site of ACE2.
Keywords: ACE2, bioactive compound, mango peel, mangiferin, waste
Antibacterial Activity of Ethanol Extract of Red Betel Leaves (Piper crocatum) and Its Fractions against Escherichia coli pBR322
Authors: Chairunisa Fernanda , Safithri Mega , Bintang Maria 
Published: July 2022

Red betel leaf (Piper crocatum) is one of the typical Indonesian herbal plants that has an antibacterial function. This study aimed to test and measure the activity of 70% ethanol extract of red betel leaf and its fractions (n-hexane, ethyl acetate, and water fractions) as antibacterial against specific bacteria Escherichia coli pBR322 based on activity and minimum inhibitory concentration. Extraction was carried out using the maceration method and continued with fractionation based on the level of solvent polarity. Antibacterial activity was indicated by the presence of inhibition zones. The minimum inhibitory concentration was indicated by the appearance of the inhibition zone at the minimum concentration. Results showed that extraction process resulted in crude extract yield of 19.49%. The best antibacterial activity was shown by 1000 ppm n-hexane fraction with an inhibition zone of 2.40 mm ± 0.14. The best minimum inhibitory concentration was 100 ppm n-hexane fraction with an inhibition zone of 0.60 mm ± 0.56.
Demokrasi dan Sistem Pemerintahan
Authors: Noviati Cora Elly 
Published: July 2022

Democracy provides an understanding that the source of power is the people with an understanding that people will give birth to a rule that will benefit and protect their rights. In order for that to happen, a rule is needed to support the idea and serves as the foundation in the life of the state to guarantee and protect the rights of the people. Such rule is called The Constitution.The understanding on the highest power itself does not need to be understood in the sense of absolute monistic and unlimited, because it is in itself that the supreme power which is in the hands of the people is limited by the agreement they set forth together as outlined in the formulation of the constitution they made and promulgated especially on the founding of the state. This is what is called the social contract between citizens as reflected in the constitution. It is that constitution which limits and regulates how the sovereignty of the people is channeled, executed and maintained in state activities and day-to- day running of the government. In essence, within the idea of popular sovereignty, it remains to be guaranteed that the people are the true owners of the State with all its authority to carry out all the functions of state power, both in the field of legislative, executive, and judiciary. It is the people who have the authority to plan, organize, implement, and conduct monitoring and assessment of the implementation of the power functions. Even further, it is for the benefit of the people that every activities aimed at. It is for the people that all the benefits gained from the functioning and the organization of the state are intended. This is the idea of popular sovereignty or democracy that is totally of the people, for the people, by the people, and with people.
PENGAKUAN NEGARA TERHADAP HAK-HAK POLITIK (RIGHT TO VOTE) MASYARAKAT ADAT DALAM PELAKSANAAN PEMILIHAN UMUM (Studi Putusan Mahkamah Konstitusi No.47-81/PHPU.A-VII/2009)
Authors: Zazili Ahmad 
Published: July 2022

Constitutional right is basic right for all Indonesian people, not least for indigenous people which still uphold the values of their customary law. Customary law is often different from the positive law in Indonesia, but it’s not a reason to deny the customary law on indigenous people in a region. One of the Indigenous people is in Yahukimo where the community uses their customary law in various patterns of life. Therefore, even in the election they use their own customary law and are not guided by the Election Law. Noken is the way they cast a vote. Constitutionality of Noken is accepted as a cultural value by the Constitutional Court.
Rekonstruksi Sistem Pemerintahan Presidensiil Berdasar Undang- Undang Dasar 1945 Menuju Sistem Pemerintahan Presidensiil Murni
Authors: Sulardi Sulardi 
Published: July 2022

Indonesian governmental system is conducted based on 1945 Constitution. When varied constitutions were implemented in Indonesia in the past, the consequence is there were varied political systems. In 1999-2002, there were changes in 1945 Constitution. One of the objectives is to strengthen presidential system of government. It was expected that the amended Constitution could become the foundation of the good, effective, and efficient presidential system of government. In fact, the amended Constitution does not yet specified the characteristics of the presidential system of government, so there is awareness that a reconstruction into the presidential system of government is needed. Since 1945 independence until transition period, presidential system of government based on 1945 Constitution was conducted inconsistently because 1945 Constitution was arbitrarily interpreted by the presidents in their terms of office. Theoretically, there was a new concept on the presidential system of government, that is the pure presidential system of government. Practically, if the concept is included in 1945 Constitution, the consequence is that the president has relatively equal position among others state institutions. Then, the presidential system of government can effectively and efficiently run because each of state institutions, especially President and Parliament, can focus their attention to their tasks and duties.
SISTEM KLASTERISASI DATA KESEHATAN PENDUDUK UNTUK MENENTUKAN RENTANG DERAJAT KESEHATAN DAERAH MENGGUNAKAN K-MEANS
Authors: Syahputra Indra , Ilhamsyah Ilhamsyah , Rahmayuda Syahru , Febrianto Ferdy 
Published: July 2022

Pencapaian suatu negara dalam memberikan jaminan di bidang kesehatan dapat menjadi indikator untuk mengetahui tingkat keberhasilan pembangunan sebuah negara. Di Indonesia khususnya Kota Pontianak tingkat kesehatan masih menjadi sebuah tantangan yang harus diselesaikan. Sebagai upaya memudahkan proses identifikasi kesehatan masyarakat dan mengetahui tingkat kesehatan suatu wilayah di Kota Pontianak, maka pada penelitian ini akan mengimplementasikan clustering K-Means dalam pengelompokkan setiap wilayah kecamatan berdasarkan 5 buah variabel indikator mortalitas derajat kesehatan untuk memudahkan Dinas Kesehatan kota Pontianak mengetahui tingkat kesehatan masyarakat di setiap wilayah kecamatan. Hasil dari penelitian ini berupa sistem klasterisasi data kesehatan yang mampu menghasilkan tiga buah cluster meliputi tingkat kesehatan rendah, sedang, dan tinggi. Cluster 1 memiliki nilai CBR 0,24; CDR 0,73; IMR 0,27; FMR 0,12; dan MMR 0,14 berisi 3 wilayah kecamatan. Cluster 2 beranggota 1 kecamatan memiliki nilai CBR 0,57; CDR 0,34; IMR 1, FMR 1, dan MMR 0. Dan cluster 3 memiliki nilai CBR 0,95; CDR 0,06; IMR 0,11; FMR 0,27; dan MMR 0,87; berjumlah 2 kecamatan. Pengujian fungsional memperoleh hasil yang sesuai berdasarkan perancangan sistem. Sedangkan pengujian interface memperoleh nilai persentase 88% yang menunjukkan hasil sangat baik.
EFEK ANTIDIARE EKSTRAK ETANOL UMBI RUMPUT TEKI (Cyperus rotundus L.) TERHADAP MENCIT PUTIH
Authors: Lina Rifda Naufa , Astutik Monik Dewi 
Published: July 2022

ABSTRACT
Diarrhea is a disease characterized by stimulation of bowel movements continuously and feces that
are not formed or liquid that has a frequency of more than 3 times in 24 hours. The incidence of
diarrhea can occur throughout the world and causes 4% of all deaths and 5% of health losses to
cause disability. Cyperus rotundus L. can be used as an antidiarrheal drug because it contains a
compound such as tannins and flavonoids. This research is an experimental study with a Post-test
only Control Group Design. The subjects using white male mice (Mus muscullus) 25 mice and
divided into 5 groups: positive control, negative control, ethanol extracts of rubers Cyperus
rotundus L. with a dose of 250 mg/kgBB, 500 mg/kgBB and 1000 mg/kgBB. Before the treatment,
mice fasted and induced diarrhea (oleum ricini). Obsevations was made by observing the
parameters of diarrhea: duration of diarrhea, frequency of diarrhea and feces consistency every 30
minutes for 4 hours. The numerical data was then processed using SPSS with one way ANOVA test.
The results obtained showed that the administration of extract with a dose of 250 mg/kgBB, 500
mg/kgBB and 1000 mg/kgBB had an antidarrheal with effective dose is 500 mg/kgBB.
Keywords: antidiarrheal, ethanol extract of tubers Cyperus rotundus L., oleum ricini, Cyperus
rotundus
Relationship between clinical outcome measurements and muscle thickness in cerebral palsy
Authors: Park Chanhee , Oh Wonjun 
Published: July 2022

BACKGROUND: The World Health Organization (WHO) uses the International Classification of Functioning, Disability, and Health (ICF) model to provide physical therapy diagnoses and interventions. However, the relationship between clinical assessment and imaging remains unclear. OBJECTIVE: This study aimed to determine the relationships between body function/structure, activity, and participation outcomes following neurorehabilitation in children with cerebral palsy (CP). METHODS: Nineteen children (9 girls mean age 8.8 [Formula: see text] 1.8 years) with CP participated in this study. Clinical motor function tests included the quality of upper extremity skills test (QUEST), Wolf motor function test (WMFT), Functional Independence Measure for Children (WeeFIM), and the Jebsen-Taylor Hand Function Test (JTHFT). Ultrasound imaging was used to measure muscle thickness, which characterizes the body structure, and activity domain variables. RESULTS: The correlations between body structure domain (muscle thickness), activity domain (QUEST, WMFT, WeeFIM) and participants variable (JTHFT) were significant, ranging from [Formula: see text]0.484 to 0.893, [Formula: see text] 0.05. CONCLUSIONS: These novel findings suggest that muscle thickness ultrasound imaging is closely associated with WMFT, WeeFIM, and QUEST variables. This finding provides important clinical insights when using broad clinical assessment and imaging in children with CP.
Design and test validation of a novel permanent magnet eddy current brake
Authors: Ye Lezhi , Chen Zhao , Ma Zhongwei , Qiu Haolin , Chai Shiwei 
Published: July 2022

Aiming at slippage and belt breakage of large mechanical conveyor belts, a new type of water-cooled permanent magnet brake (WPMB) is proposed. In order to determine the braking performance of WPMB, a multi-physics coupling model and analysis method of magneto-thermal-structure are built. The braking torque and temperature characteristics of WPMB under different working conditions are obtained. Based on the magnetic vector potential equation, an electromagnetic eddy current model is established, and the variation trend of braking torque with speed is predicted. The temperature field model is built based on the equivalent thermal network method. Using multi-field coupling analysis method and 3-D FEM, the influence factors of WPMB braking torque are analyzed. Two test prototypes with rated speed of 78 rpm, braking torque of 3000 N⋅m are designed and developed. Braking torque characteristic tests and magnetic shielding characteristic tests at different speeds and continuous braking characteristic test are carried out. Experiments show that the proposed method provides very practical results to ensure the continuous and stable operation of WPMB.
Can Dopamine Responsiveness Be Predicted in Parkinson’s Disease Without an Acute Administration Test?
Authors: Betrouni Nacim , Moreau Caroline , Rolland Anne-Sophie , Carrière Nicolas , Viard Romain , Lopes Renaud , Kuchcinski Gregory , Eusebio Alexandre , Thobois Stephane , Hainque Elodie , Hubsch Cecile , Rascol Olivier , Brefel Christine , Drapier Sophie , Giordana Caroline , Durif Franck , Maltête David , Guehl Dominique , Hopes Lucie , Rouaud Tiphaine , Jarraya Bechir , Benatru Isabelle , Tranchant Christine , Tir Melissa , Chupin Marie , Bardinet Eric , Defebvre Luc , Corvol Jean-Christophe , Devos David ,   the PREDISTIM Study Group
Published: July 2022

Background: Dopamine responsiveness (dopa-sensitivity) is an important parameter in the management of patients with Parkinson’s disease (PD). For quantification of this parameter, patients undergo a challenge test with acute Levodopa administration after drug withdrawal, which may lead to patient discomfort and use of significant resources. Objective: Our objective was to develop a predictive model combining clinical scores and imaging. Methods: 350 patients, recruited by 13 specialist French centers and considered for deep brain stimulation, underwent an acute L-dopa challenge (dopa-sensitivity > 30%), full assessment, and MRI investigations, including T1w and R2* images. Data were randomly divided into a learning base from 10 centers and data from the remaining centers for testing. A machine selection approach was applied to choose the optimal variables and these were then used in regression modeling. Complexity of the modelling was incremental, while the first model considered only clinical variables, the subsequent included imaging features. The performances were evaluated by comparing the estimated values and actual values Results: Whatever the model, the variables age, sex, disease duration, and motor scores were selected as contributors. The first model used them and the coefficients of determination (R2) was 0.60 for the testing set and 0.69 in the learning set ( p < 0.001). The models that added imaging features enhanced the performances: with T1w (R2 = 0.65 and 0.76, p < 0.001) and with R2* (R2 = 0.60 and 0.72, p < 0.001). Conclusion: These results suggest that modeling is potentially a simple way to estimate dopa-sensitivity, but requires confirmation in a larger population, including patients with dopa-sensitivity < 30%
Financial Inclusion and Macroeconomic Stability in South Africa
Authors: Matsebula Velenkosini , Sheefeni Johannes 
Published: July 2022

While Financial inclusion has been largely considered to play an important role to eradicate poverty and boost economic prosperity, some empirical literature has shown differing sentiments, suggesting that vast access to finance may potentially bring about market instability to the economy. This relationship between financial inclusion and macroeconomic stability is in greatly under researched, from a global and local perspective. This paper utilizes a VAR model to analyse the relationship between financial inclusion and macroeconomic stability in South Africa, using quarterly time series data from 2004 to 2019. To measure macroeconomic stability, the study used two macroeconomic factors, namely output and inflation, and commercial bank branches per 100,000 adults (CBB) was used as a measure of financial inclusion. The results find a positive relationship between financial inclusion and output, a 1% increase in CBB causes output to increase by 0.04%. Financial inclusion is also found to have a positive impact on inflation in the long run. Important policy implications point to the importance of financial inclusion in impacting output, and the need to find a balance between financial inclusion and inflation control. As such, Macroeconomic policy maker can use financial inclusion as a tool to retain macroeconomic stability.
Kesalahan siswa kelas unggulan dalam menyelesaikan soal materi pecahan berdasarkan langkah-langkah Polya
Authors: Yulita Yuki , Ishartono Naufal 
Published: July 2022

Telah banyak hasil penelitian terdahulu yang mengkaji terkait kesalahan siswa dalam mengerjakan soal pecahan ditinjau dari langkah-langkah Polya. Namun ditemukan masih sedikit penelitian yang mengkaji kasus tersebut terhadap siswa di kelas unggulan. Oleh karena itu, tujuan penelitian ini adalah untuk menganalisis kesalahan siswa kelas unggulan dalam menyelesaikan soal materi pecahan berdasarkan langkah-langkah Polya serta faktor-faktornya. Penelitian ini adalah penelitian kualitatif dengan pendekatan deskriptif. Jumlah siswa yang menjadi sample dalam penelitian ini adalah sebanyak enam orang siswa kelas unggulan di SMA Negeri 1 Cilacap pada bulan Oktober 2020 sampai dengan bulan Februari 2021 yang dipilih menggunakan tehnik purposive sampling. Hasil dari penelitian ini, siswa cenderung salah pada tiga tahapan Polya yaitu (1) pada langkah Understanding The Problem dimana siswa tidak menuliskan apa yang diketahui dan tidak menuliskan apa yang ditanyakan pada soal serta hanya menuliskan apa yang diketahui tetapi tidak menuliskan apa yang ditanyakan, (2) pada langkah Make A Plan dimana siswa salah dan tidak sesuai dengan permasalahan dalam membuat rencana yang digunakan untuk menyelesaikan soal, menuliskan langkah-langkah dalam menyelesaikan soal tetapi kurang tepat, dan (3) pada langkah Carry Out The Plan dimana siswa melakukan kesalahan dalam perhitungan. Sedangkan pada tahap Look Back, siswa tidak mengalami kesalahan. Sedangkan faktor-faktor yang menyebabkan siswa melakukan kesalahan antara lain siswa merasa takut terkait tidak cukupnya waktu untuk menjawab soal, siswa terburu-buru dalam menjawab soal, kebiasaan siswa dalam menjawab soal, siswa tidak paham maksud soal, siswa tidak teliti dalam membaca soal, siswa kurang memahami soal, tergesa-gesa dalam menjawab dan menghitung dan tidak teliti dalam melakukan perhitungan.