bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and antibacterial and antioxidant ability of β‐cyclodextrin complexes of vaporized Illicium verum essential oil
Authors: Wu Kegang , Zhang Tong , Chai Xianghua , He Dong , Duan Xuejuan , Yu Bingying , Chen Yongqi , Huang Yuqiang 
Published: July 2022

AbstractCompared with traditional liquid–liquid embedding method and solid–liquid embedding method of inclusion complexes of β‐cyclodextrin (β‐CD) inclusion of essential oil to form stable properties, the gas–liquid embedding method was applied to encapsulate vaporized illicium verum essential oil (IvEO), with β‐CD as wall materials so that core and wall materials molecules are in active state during complexing process. At optimal conditions with a mass ratio of 1:10, temperature of 80°C, time of 1 h, the β‐CD‐IvEO inclusion complexes (β‐CD‐IvEO‐ICs) had an encapsulation efficiency (EE) of 84.55 ± 2.31%. Fourier transform infrared spectroscopy (FTIR) revealed the encapsulation of IvEO into inclusion complexes, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) demonstrated the enhanced thermal stability of IvEO after embedding. Furthermore, the reducing power and 2‐phenyl‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide (PTIO)‐scavenging capacity displayed certain capacity of antioxidation in a short time but stronger antioxidative activities as reaction time was extended. The diameter of growth zone (DGZ) indicated stronger antibacterial activity of β‐CD‐IvEO‐ICs against Escherichia coli, Bacillus subtilis, Staphylococcus epidermidis, and Staphylococcus aureus. Moreover, the β‐CD‐IvEO‐ICs could induce the bacteria producing more reactive oxygen species (ROS) than IvEO, resulting in bacterial death.
Variability in observed stable water isotopes in snowpack across a mountainous watershed in Colorado
Authors: Carroll Rosemary W. H. , Deems Jeffery , Maxwell Reed , Sprenger Matthias , Brown Wendy , Newman Alexander , Beutler Curtis , Bill Markus , Hubbard Susan S. , Williams Kenneth H. 
Published: July 2022

AbstractIsotopic information from 81 snowpits was collected over a 5‐year period in a large, Colorado watershed. Data spans gradients in elevation, aspect, vegetation, and seasonal climate. They are combined with overlapping campaigns for water isotopes in precipitation and snowmelt, and a land‐surface model for detailed estimates of snowfall and climate at sample locations. Snowfall isotopic inputs, describe the majority of δ18O snowpack variability. Aspect is a secondary control, with slightly more enriched conditions on east and north facing slopes. This is attributed to preservation of seasonally enriched snowfall and vapour loss in the early winter. Sublimation, expressed by decreases in snowpack d‐excess in comparison to snowfall contributions, increases at low elevation and when seasonal temperature and solar radiation are high. At peak snow accumulation, post‐depositional fractionation appears to occur in the top 25 ± 14% of the snowpack due to melt‐freeze redistribution of lighter isotopes deeper into the snowpack and vapour loss to the atmosphere during intermittent periods of low relative humidity and high windspeed. Relative depth of fractionation increases when winter daytime temperatures are high and winter precipitation is low. Once isothermal, snowpack isotopic homogenization and enrichment was observed with initial snowmelt isotopically depleted in comparison to snowpack and enriching over time. The rate of δ18O increase (d‐excess decrease) in snowmelt was 0.02‰ per day per 100‐m elevation loss. Isotopic data suggests elevation dictates snowpack and snowmelt evolution by controlling early snow persistence (or absence), isotopic lapse rates in precipitation and the ratio of energy to snow availability. Hydrologic tracer studies using stable water isotopes in basins of large topographic relief will require adjustment for these elevational controls to properly constrain stream water sourcing from snowmelt.
Pre‐K attendance and social development: The moderating role of kindergarten classroom experiences
Authors: Zimmermann Kathryn , Yang Qingqing , Purtell Kelly , Ansari Arya 
Published: July 2022

AbstractMany studies have established that there are important life‐long benefits of attending pre‐K. At the same time, recent research suggests that pre‐K attenders may enter and exit kindergarten exhibiting less optimal social and learning behaviours than their non‐attending peers, and little attention has been paid to what factors may contribute to these patterns of development after children enter kindergarten. The current study will address these gaps in knowledge using nationally representative data from the Early Childhood Longitudinal Study Kindergarten Class of 2011 to examine the social and learning behaviours of pre‐K attenders and nonattenders at kindergarten entry and exit. Moreover, we will determine the extent to which children's social and behavioural skills change at differential rates across the kindergarten year as a function of pre‐K attendance and their kindergarten classroom experiences, with a focus on the academic rigour, activity settings and teacher‐student relationships.
Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast‐secreted factors through the HGF/C‐MET axis
Authors: Dias Carvalho Patrícia , Martins Flávia , Mendonça Susana , Ribeiro Andreia , Machado Ana Luísa , Carvalho Joana , Oliveira Maria José , Velho Sérgia 
Published: July 2022

AbstractGenetic alterations influence the malignant potential of cancer cells, and so does the tumor microenvironment. Herein, we combined the study of KRAS oncogenic effects in colorectal cancer cells with the influence of fibroblast‐derived factors. Results revealed that mutant KRAS regulates cell fate through both autonomous and nonautonomous signaling mechanisms. Specifically, processes such as proliferation and cell‐cell aggregation were autonomously controlled by mutant KRAS independently of the stimulation with fibroblasts conditioned media. However, cancer cell invasion revealed to be a KRAS‐dependent nonautonomous effect, resulting from the cooperation between fibroblast‐derived HGF and mutant KRAS regulation of C‐MET expression. C‐MET downregulation upon KRAS silencing rendered cells less responsive to HGF and thus less invasive. Yet, in one cell line, KRAS inhibition triggered invasion upon stimulation with fibroblasts conditioned media. Inhibition of PIK3CA oncogene did not promote invasion, thus showing a KRAS‐specific effect. Moreover, the invasive capacity also depended on the HGF‐C‐MET axis. Overall, our study awards oncogenic KRAS an important role in modulating the response to fibroblast‐secreted factors either by promoting or impairing invasion, and depicts the HGF‐C‐MET axis as a putative therapeutic target to impair the invasive properties of mutant KRAS cancer cells.
Global growth on life support? The contributions of fiscal and monetary policy since the global financial crisis
Authors: Baumann Ursel , Lodge David , Miescu Mirela S. 
Published: July 2022

AbstractThis paper compares the role of monetary and fiscal policy shocks in advanced and emerging economies. Using a model with a hierarchical structure, we capture the variability of GDP response to policy shocks both between and within the groups of advanced and emerging countries. Our results show that the effects of fiscal stimulus are higher in advanced economies compared to emerging markets, while monetary policy is found to have more homogeneous effects on GDP. We quantify the policy contribution on GDP growth in the decade that followed the global financial crisis by means of a structural counterfactual analysis based on conditional forecasts. We find that global GDP growth benefited from substantial policy support during the global financial crisis but policy tightening thereafter, particularly fiscal consolidation, acted as a significant drag on the subsequent global recovery. In addition, we show that the role of policy has differed across countries. Specifically, in advanced economies, highly accommodative monetary policy has been counteracted by strong fiscal consolidation. By contrast, in emerging economies, monetary policy has been less accommodative since the global recession.
Foley catheter compared with controlled release dinoprostone vaginal insert for labor induction after one previous cesarean delivery: A randomized trial
Authors: Sulaiman Sofiah , Sivaranjani Sanmugam , Razali Nuguelis , Lim Boon Kiong , Hamdan Mukhri , Tan Peng Chiong 
Published: July 2022

AbstractObjectiveTo compare Foley catheter and controlled‐release dinoprostone vaginal insert on induction‐to‐delivery interval and maternal satisfaction in women with one previous cesarean delivery.MethodsThis randomized controlled trial was conducted at the University Malaya Medical Center, Kuala Lumpur, Malaysia, from December 12, 2018, to May 28, 2019. A total of 78 term women scheduled for labor induction with one previous cesarean delivery who had ripe cervixes, singleton gestation, cephalic presentation, intact membranes, and reassuring cardiotocogram were randomized to Foley catheter or dinoprostone insert. The primary outcome was induction‐to‐delivery interval (in hours) and the secondary outcomes included maternal satisfaction on birth experience (assessed by 100‐mm visual analog scale).ResultsInduction‐to‐delivery intervals were as follows: median 33.5 h (interquartile range [IQR], 26.1–36.2 h) versus 23.5 h (IQR, 12.7–34.5 h) (P = 0.004), and maternal satisfaction on birth process 100‐mm visual analog scale was 80 mm (IQR, 64–88 mm) versus 82 mm (IQR, 67–88 mm) (P = 0.919) for the Foley and controlled‐release dinoprostone arms, respectively. Cesarean delivery rates were 23 of 39 (59%) versus 20 of 39 (51%) (relative risk, 1.15 [95% confidence interval, 0.77–1.72]) (P = 0.496) and trial device insertion to removal time mean ± standard deviation was 20.1 ± 7.1 h versus 14.2 ± 7.3 h (P = 0.001) for Foley versus controlled‐release dinoprostone, respectively.ConclusionIn term women after one previous cesarean delivery with unripe cervixes, controlled‐release dinoprostone vaginal insert compared with Foley catheter shortens the induction‐to‐delivery interval but maternal satisfaction was not significantly increased.Clinical Trial RegistrationThis study was registered with ISRCTN on November 30, 2018, with trial identification number: ISRCTN16957529 (https://doi.org/10.1186/ISRCTN16957529). The first participant was recruited on December 12, 2018.
Changes in the local food‐at‐home environment, supplemental nutrition assistance program participation, and dietary quality: Evidence from FoodAPS
Authors: Volpe Richard , Cai Xiaowei , Tseng Marilyn , Zeballos Eliana , Sinclair Wilson 
Published: July 2022

AbstractWe study dietary quality via grocery purchases among US households using the USDA's FoodAPS data. Using data from Nielsen IQ TDLinx, we measure changes in the local food‐at‐home environment over an 8‐year span and identify impacts on the healthy eating index. The results indicate the local food environment better explain food choices and dietary quality for rural households, as compared to urban. Many of our significant findings pertain specifically to supplemental nutrition assistance program participants. Decreases in local supermarket availability is often associated with lower adherence to federal dietary recommendations, and the converse is often true for supercenters.
OPG is associated with thyroid nodule development in type 2 diabetes
Authors: Huang Dazhi , Niu Yixin , Zhang Weiwei , Li Xiaoyong , Lin Ning , Yang Zhen , Qin Li , Su Qing , Ran Hui , Zhang Hongmei 
Published: July 2022

AbstractBackgroundThyroid nodule prevalence is increasing lately, especially in diabetes, but the mechanism of which is not clear. In this study, we investigated if osteoprotegerin (OPG) is involved in the pathogenesis of thyroid nodules in diabetes.MethodsA total of 7568 individuals with detailed information and ultrasound examination results were studied for the prevalence of thyroid nodules. Among them, 1883 were with type 2 diabetes and 5685 were non‐diabetic. Then, 1120 individuals were randomly selected for the measurement of OPG. Diabetic rats were made by feeding a high‐fat‐high‐fructose diet for 28 weeks. Rats fed with a normal diet were as controls. Fresh thyroid tissues were obtained and fixed, dehydrated, and embedded in paraffin for hematoxylin‐eosin staining and observing pathological changes. qPCR and western blot were used to detect OPG expression in rat thyroid tissues.ResultsWe found that HbA1c is an independent risk factor for thyroid nodules (Exp [β] = 1.158, p < 0.001). The prevalence of thyroid nodules in type 2 diabetes was higher than that in non‐diabetes (53.9% vs. 46.7%, p < 0.001). Serum OPG levels were significantly elevated in the diabetes group than in the non‐diabetes group (3160.17 pg/ml vs. 2819.39 pg/ml, p < 0.01). The expression of OPG increased significantly in the thyroid tissues of diabetic rats.ConclusionOsteoprotegerin may be associated with thyroid nodule development in diabetes.
The CUSUM curve combined with comprehensive complication index for assessing short‐term complications of radical cystectomy
Authors: Zhou Diansheng , Gao Jie , Liao Yihao , Da La , Wang Jian , Wang Keke , Zhu Jianqiang , Hu Hailong , Wu Changli , Tian Dawei 
Published: July 2022

AbstractObjectiveTo evaluate the comprehensive complication index(CCI) and Clavien‐Dindo classification(CDC) for short‐term postoperative complications in radical cystectomy and assess cumulative surgical morbidity to compare sufficient surgical skill.MethodsFrom September 30, 2010, to October 1, 2020, clinical data of patients with urothelial carcinoma who underwent radical cystectomy with urinary diversion were gathered, patients who had only a urinary diversion, bladder sparing surgery, additional abdominal surgeries at the same time were all excluded. The CDC and CCI were utilized to evaluate 30‐d complications after radical cystectomy and the relevance of hospital stay was compared between CCI and CDC. The cumulative sum control models (CUSUM) were used to evaluate the overall surgical morbidity of radical cystectomy in our facility and for comparisons between surgeons.ResultsThis study enrolled a total of 635 individuals, 548 (86.3%) of whom had 1124 problems. The incidence of severe complications (CDC≥ Grade III) was 10.2%. The average CCI was 20.2 ± 14.7. Gender, urinary diversion subtype, procedure method, and surgeon were significantly correlated with the increase of CCI (p < 0.05). The CCI demonstrated a better relationship with hospital stay (R2 = 0.429) than the CDC (R2 = 0.361). The CUSUM‐CCI model demonstrated a difference and growth distribution in dynamic time between individual surgeons.ConclusionsCCI can better reflect the incidence of complications for radical cystectomy than CDC, and CCI is more strongly correlated with postoperative hospital stay. The CUSUM‐CCI model can reflect the quality of surgical skill for each surgeon instantaneously.
Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF‐β/Smad pathway
Authors: Wu Ying‐Li , Hong Lian‐Lian , Ling Zhe‐Nan , Hu Xuan‐Yu , Liu Zhu , Li Pei , Ling Zhi‐Qiang 
Published: July 2022

AbstractObjectivesTo investigate the function of PAQR3 in gastric cardia adenocarcinoma (GCA) and understand the possible mechanism of PAQR3 in regulating epithelial–mesenchymal transition (EMT).MethodsWe detected PAQR3 protein in 146 GCA tissues and paired normal adjacent tissues (PNTs) specimens using immunohistochemical analysis, and explored its clinical significance. The expression levels of PAQR3 protein in 20 GCA tissues, their paired PNTs, HGC27, SGC7901, and GES‐1 cells were analyzed by Western blot. Wild‐type PAQR3 was overexpressed in HGC27 cells. The effects of PAQR3 overexpression on the function of HGC27 cells and its underlying mechanisms were then analyzed through a series of cell and molecular biology experiments.ResultsPAQR3 was significantly down‐regulated in GCA tissues when compared with paired PNTs (p < 0.0001). The expression level of PAQR3 in GCA tissues was significantly negatively correlated with Helicobacter pylori infection (p = 0.000), venous invasion (p = 0.000), invasion depth (p = 0.000), lymph node metastasis (p = 0.022), tumor stage (p = 0.000), and patient survival (p = 0.009). Downregulation of PAQR3 was highly correlated with increased EMT signature and activated TGF‐β/Smad pathway in GCA tissues. Overexpression of PAQR3 in HGC27 cells negatively regulates its cellular functions, such as cell proliferation and migration, and suppresses EMT. Mechanistically, overexpression of PAQR3 significantly down‐regulates the protein expression levels of TGF‐1, p‐Smad2, and p‐Smad3 in HGC27 cells.ConclusionPAQR3 was significantly down‐regulated in GCA tissues, HGC27, and SGC7901 cells. PAQR3 significantly inhibits the proliferation, migration, and invasion of HGC27 cells. Mechanistically, PAQR3 can inhibit the EMT process in HGC27 cells by regulating TGF‐β/Smad signaling pathway.
Urine inter‐alpha‐trypsin inhibitor family‐related proteins may serve as biomarkers for disease activity of lupus
Authors: Jiang Jun , Zhao Jin , Wang Yuhua , Liu Dan , Zhang Man 
Published: July 2022

AbstractBackgroundSystemic lupus erythematosus (SLE) is a chronic inflammatory disease involving multiple tissues. Inter‐Alpha‐Trypsin Inhibitor (ITI) family proteins have a role in maintaining tissue homeostasis, but their possible clinical significance in the SLE patients has not been reported. The aim of this study was to analyze and verify the expression of ITI‐related proteins in the urine of SLE patients, further explore the features of these proteins in disease activity.MethodsBased on label‐free proteomics technology and bioinformatics technology, we analyzed the expression of ITI family‐related proteins in the urine of lupus. Subsequently, Western‐blot and targeted proteomics were used to qualitatively and quantitatively verify the expression of these proteins, respectively.ResultsA total of seven ITI family‐related proteins were screened and identified; and six of these proteins were differentially expressed in the urine of SLE patients. Further quantitative analysis showed that the expressions of ITIH2, ECM1, and ITIH5 in urine between active SLE group and stable SLE group were consistent with the preliminary screening results. The expression of ITIH2 and ECM1 in the renal damage group were also consistent with the screening results. Moreover, ITIH2 and ECM1 have a good correlation with disease activity and have a certain correlation with renal damage.ConclusionsIn this exploratory study, we evaluated the expression of ITI family‐related proteins in the urine of SLE and found that urine ITIH2 and ECM1 were closely related to SLE activity, especially kidney damage, providing an experimental basis for further exploration of the potential roles in monitoring lupus and lupus nephritis activity.
Thought experiments: Review and recommendations
Authors: Aguinis Herman , Beltran Jose R. , Archibold Estelle E. , Jean Esther L. , Rice Darryl B. 
Published: July 2022

SummaryThought experiments have been used as an effective methodological approach to advance theory in numerous scientific fields. However, they are underutilized in organizational behavior (OB) and adjacent fields. Accordingly, we conducted a comprehensive and multidisciplinary literature review of thought experiments that entailed 174 sources in economics, psychology, marketing, medicine, sociology, finance, and other fields. We used insights from this literature review to define and describe the unique nature of thought experiments and offer a taxonomy of four main types based on a theory's development stage (i.e., early vs. late) and a study's theoretical goal (i.e., confirmation vs. disconfirmation). We also provide a decision‐making tree useful for evaluating whether conducting a thought experiment is beneficial for a particular research situation and which of the four types is most likely to produce a meaningful contribution. Then, we offer best‐practice recommendations for conducting thought experiments that address how to plan, execute, report results, and discuss implications. In addition, we demonstrate the potential of thought experiments by using the best‐practice recommendations to design and conduct a thought experiment in the domain of workplace allyship. Finally, we offer suggestions for future substantive research that would benefit from thought experiment methodology (i.e., diversity, equity, and inclusion; leadership; performance; selection and recruitment; teams; and turnover). Overall, our article offers a comprehensive review and recommendations that we hope will be a catalyst for using thought experiments to advance theory in OB and related fields.
Functional assessment of total hip arthroplasty using inertial measurement units: Improvement in gait kinematics and association with patient‐reported outcome measures
Authors: Kaufmann Mara , Nüesch Corina , Clauss Martin , Pagenstert Geert , Eckardt Anke , Ilchmann Thomas , Stoffel Karl , Mündermann Annegret , Ismailidis Petros 
Published: July 2022

AbstractInertial measurement units (IMUs) are commonly used for gait assessment, yet their potential for quantifying improvements in gait function and patterns after total hip arthroplasty (THA) has not been fully explored. The primary aim of this study was to compare spatiotemporal parameters and sagittal plane kinematic patterns of patients with hip osteoarthritis (OA) before and after THA, and to asymptomatic controls. The secondary aim was to assess the association between dynamic hip range of motion (ROM) during walking and the Hip Osteoarthritis Outcome Scores (HOOS). Twenty‐four patients with hip OA and 24 matched asymptomatic controls completed gait analyses using the RehaGait® sensor system. Patients were evaluated pre‐ and 1 year postoperatively, controls in a single visit. Differences in kinematic data were analyzed using statistical parametric mapping, and correlations between dynamic hip ROM and HOOS were calculated. Walking speed and stride length significantly increased (+0.08 m/s, p = 0.019; +0.06 m, p = 0.048) after THA but did not reach the level of asymptomatic controls (−0.11 m/s, p = 0.028; −0.14 m, p = 0.001). Preoperative hip and knee kinematics differed significantly from controls. After THA, they improved significantly and did not differ from controls. Dynamic hip flexion‐extension ROM correlated positively with all HOOS subscores (r > 0.417; p ≤ 0.001). The change in HOOS symptoms in patients was explained by the combination of baseline HOOS symptoms and change in dynamic hip ROM (r2 = 0.748) suggesting that the additional information gained with IMU gait analysis helps to complement and objectify patient‐reported outcome measures pre‐ and postoperatively and monitor treatment‐related improvements.