bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Bisphosphonates Treatments in Osteopenic Older Women: A Systematic Review and Meta-Analysis
Authors: Li Jiangbi , Sun Yang , Chen Zhuo , Xie Xiaoping , Gu Feng , Bi Songqi , Yu Tiecheng 
Published: May 2022

Aims: To review the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women.Methods: Relevant articles published before February 2022 were searched in PubMed, EMBASE, and the Cochrane Library. All randomized controlled trials that reported incident fractures, bone mineral density (BMD), bone markers, or adverse events with bisphosphonates in osteopenic older women were included. The quality of included studies was assessed using the Cochrane Risk of Bias tool. The risk ratios (RRs) for fractures, net percent change in bone mineral density and differences in bone markers were calculated using a meta-analysis.Results: A total of 11 studies were included in our meta-analysis. Bisphosphonates significantly increased the percent changes in the lumbar spine BMD (WMD, 5.60; 95% CI, 4.16–7.03; I2 = 93.6%), hip BMD (WMD, 4.80; 95% CI, 2.93 to 6.66; I2 = 97.1%), total body BMD (WMD, 3.24; 95% CI, 2.12–4.35; I2 = 90.9%), femoral neck BMD (WMD, 4.02; 95% CI, 1.70–6.35; I2 = 91.8%) and trochanter BMD (WMD, 5.22; 95% CI, 3.51–6.93; I2 = 83.6%) when compared to placebo. Zoledronate was associated with a great treatment effect on fragility fracture (RR, 0.63; 95% CI, 0.50–0.79), clinical vertebral fracture (RR, 0.41; 95% CI, 0.22–0.76), and radiographic vertebral fracture (RR, 0.60; 95% CI, 0.27–1.35) compared to placebo. Meanwhile, alendronate was also associated with beneficial effects on fragility fracture (RR, 0.40; 95% CI, 0.15–1.07), clinical vertebral fracture (RR, 0.46; 95% CI, 0.17–1.24), and radiographic vertebral fracture (RR, 0.64; 95% CI, 0.38–1.09). In addition, the use of bisphosphonates reduced the concentration of procollagen type I N-terminal propeptide (PINP) and C-terminal telopeptide of type I collagen (CTX) over placebo by 15.79 (95% CI, −18.92 to −12.66; I2 = 28.4%), −0.23 (95% CI, −0.35 to −0.10; I2 = 91.3%), respectively. Although there was insufficient evidence to determine their safety, these bisphosphonates may have an effect on cancer, cardiac events, and mortality in osteopenic older women.Conclusion: All bisphosphonates examined were associated with beneficial effects on fractures, BMD, and bone markers in women with osteopenia. Further randomized controlled trials are necessary to clarify the safety of bisphosphonates in women with osteopenia.
Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model
Authors: Hou Lanwei , Miao Jingyu , Meng Haiwei , Liu Xiao , Wang Di , Tan Yawen , Li Chuangang 
Published: May 2022

BackgroundMajor depressive disorder (MDD) refers to a mental disease with complex pathogenesis and treatment mechanism. S-ketamine exhibited high effectiveness in treating MDD. However, the pharmacological activity of S-ketamine has not been reported yet.Materials and MethodsIn this study, depression-like characteristics were induced by chronic unpredictable stress (CUS). After S-ketamine (15 mg/kg) was intraperitoneally injected, the behaviors of mice were tested by conducting open-field test, elevated plus maze test, tail suspension test, and forced swimming test. Bilateral injection of sirtuin type 1 (SIRT1) inhibitor EX-527 was injected into the medial prefrontal cortex (mPFC) to upregulate the SIRT1 expression. The expression of SIRT1 and brain-derived neurotrophic factor (BDNF) was detected by conducting Western blot and immunofluorescence assays. Meanwhile, the synaptic ultrastructure was detected by transmission electron microscopy.ResultsIn this study, the mice showed depression-like behavior in a series of behavioral tests. After the treatment with S-ketamine, the depression-like behavior stopped. Further, the synaptic ultrastructure in mPFC, including the decreased curvature of the post synaptic density and thinning of the postsynaptic density, improved after the S-ketamine treatment. Moreover, we found that S-ketamine had the possibility of spontaneous binding with SIRT1 at the molecular level and reversed CUS-induced SIRT1 reduction. Meanwhile, a positive relationship between SIRT1 and BDNF expression in mPFC and SIRT1 inhibitor limited the role of S-ketamine in reducing the depression-like behavior and increasing the BDNF level.ConclusionS-ketamine upregulated the SIRT1-mediated BDNF in mPFC and reversed the synaptic structural defects caused by CUS. SIRT1 is a mediator of S-ketamine in alleviating depression-like behavior.
Predicting Managers' Mental Health Across Countries: Using Country-Level COVID-19 Statistics
Authors: Li Lun , Zhang Stephen X. , Graf-Vlachy Lorenz 
Published: May 2022

BackgroundThere is limited research focusing on publicly available statistics on the Coronavirus disease 2019 (COVID-19) pandemic as predictors of mental health across countries. Managers are at risk of suffering from mental disorders during the pandemic because they face particular hardship.ObjectiveWe aim to predict mental disorder (anxiety and depression) symptoms of managers across countries using country-level COVID-19 statistics.MethodsA two-wave online survey of 406 managers from 26 countries was performed in May and July 2020. We used logistic panel regression models for our main analyses and performed robustness checks using ordinary least squares regressions. In the sample, 26.5% of managers reached the cut-off levels for anxiety (General Anxiety Disorder-7; GAD-7) and 43.5% did so for depression (Patient Health Questionnaire-9; PHQ-9) symptoms.FindingsWe found that cumulative COVID-19 statistics (e.g., cumulative cases, cumulative cases per million, cumulative deaths, and cumulative deaths per million) predicted managers' anxiety and depression symptoms positively, whereas daily COVID-19 statistics (daily new cases, smoothed daily new cases, daily new deaths, smoothed daily new deaths, daily new cases per million, and smoothed daily new cases per million) predicted anxiety and depression symptoms negatively. In addition, the reproduction rate was a positive predictor, while stringency of governmental lockdown measures was a negative predictor. Individually, we found that the cumulative count of deaths is the most suitable single predictor of both anxiety and depression symptoms.ConclusionsCumulative COVID-19 statistics predicted managers' anxiety and depression symptoms positively, while non-cumulative daily COVID-19 statistics predicted anxiety and depression symptoms negatively. Cumulative count of deaths is the most suitable single predictor of both anxiety and depression symptoms. Reproduction rate was a positive predictor, while stringency of governmental lockdown measures was a negative predictor.
Association Between Residence Status Regularization and Access to Healthcare for Undocumented Migrants in Switzerland: A Panel Study
Authors: Fakhoury Julien , Burton-Jeangros Claudine , Consoli Liala , Duvoisin Aline , Jackson Yves 
Published: May 2022

BackgroundSwitzerland has a universal healthcare system. Yet, undocumented migrants face barriers at different levels that hinder their access to healthcare services. The aim of this study is to assess whether undocumented migrants' healthcare utilization improves with residence status regularization.MethodsWe used two-wave panel data from the Parchemins study, a study exploring the impact of regularization on undocumented migrants' health in Geneva, Switzerland. First wave data were collected between 2017 and 2018, second wave data between 2019 and 2020. At baseline, the sample consisted of 309 undocumented migrants, recruited after the implementation of a temporary regularization policy in Geneva. We distributed them into two groups according to their residence status 12 months before the second data collection [regularized vs. undocumented (controls)]. Using as dependent variable the number of medical consultations within two distinct 12-months periods (the first before regularization, the second after regularization), we conducted multivariable regression analyses applying hurdle specification to identify factors enhancing healthcare utilization. Then, we estimated first-difference panel models to assess change in healthcare utilization along regularization. Models were adjusted for demographic, economic and health-related factors.ResultsOf the 309 participants, 68 (22%) were regularized. For the 12 months before regularization, these migrants did not significantly differ in their healthcare utilization from the controls. At this stage, factors increasing the odds of having consulted at least once included being a female (aOR: 2.70; 95% CI: 1.37–5.30) and having access to a general practitioner (aOR: 3.15; 95% CI: 1.62–6.13). The factors associated with the number of consultations apart from underlying health conditions were the equivalent disposable income (aIRR per additional CHF 100.-: 0.98; 95% CI: 0.97–1.00) and having access to a general practitioner (aIRR: 1.45; 95% CI: 1.09–1.92). For the 12 months after regularization, being regularized was not associated with higher odds of having consulted at least once. However, among participants who consulted at least once, regularized ones reported higher counts of medical consultations than controls (3.7 vs. 2.6, p = 0.02), suggesting a positive impact of regularization. Results from the first-difference panel models confirmed that residence status regularization might have driven migrants' healthcare utilization (aβ: 0.90; 95% CI: 0.31-1.77).ConclusionsThis study supports the hypothesis that residence status regularization is associated with improved healthcare utilization among undocumented migrants. Future research is needed to understand the mechanisms through which regularization improves undocumented migrants' use of healthcare services.
Patients' Responses to COVID-19 Pandemic: The Relationship Between Potential Pandemic-Induced Disruptions, Ontological Security, and Adaptive Responses in Taizhou, China
Authors: Luo Chengwen , Wu Xiaoyan , Wang Weizhen , Zhang Mei-Xian , Cheng Fengmin , Chen Haixiao , Tung Tao-Hsin 
Published: May 2022

BackgroundThe COVID-19 pandemic has changed the social environment of most individuals around the world and has profoundly impacted people's lives, ontological security, and behavior. Among them, the patients are one of the groups most influenced by the pandemic.ObjectiveThe present research aimed to study the relationship of COVID-19 pandemic-induced disruption to patients' daily lives, ontological security, and patients' responses to prevent the spread of COVID-19, and explore the role of ontological security.MethodsThis article was based on an online structured questionnaire study conducted among hospitalized patients in Taizhou Hospital of Zhejiang Province, Taizhou, China, from 8 July to 11 August 2021. We analyzed the data using the multivariate regression model and mediation analysis method.ResultsThe results showed that the higher the pandemic-induced disruption to inpatients' lives, the better behavior would be taken by hospitalized patients to prevent the spread of COVID-19, and the perceived scarcity of ontological security played a mediating role in this process. Higher pandemic-induced disruption to patients' lives increased the ontological insecurity which further, in turn, reduced patients' good practice toward measures to prevent the novel coronavirus.ConclusionThese findings provided direct evidence for the relationship between pandemic-induced disruption, scarcity of ontological security, and patients' prevention behavior. It suggested that there was a need to emphasize patients' ontological security. Overall, these findings suggested that it is important to emphasize the mental health among patients during the COVID-19 pandemic, and implement strategies to offer psychological support when needed.
Retrospective Preliminary Assessment of Routine Follow-Up Low-Field Magnetic Resonance Imaging in Dogs Presumptively Diagnosed With Discospondylitis
Authors: de Freitas Maria Ines , Vettorato Enzo , Scarpante Elena , Cherubini Giunio Bruto , Caine Abby 
Published: May 2022

BackgroundThe usefulness of routine follow-up Magnetic Resonance Imaging (MRI-2) in asymptomatic dogs treated for discospondylitis is unknown.MethodsThis cross-sectional retrospective study investigated the features of MRI-2 in a heterogeneous group of dogs treated for discospondylitis, and if these were associated with the presence or absence of clinical signs. After comparing initial MRI (MRI-1) and MRI-2, an observer, blinded to the dog's clinical signs, described the MRI-2 findings. The study population was then divided into symptomatic or asymptomatic at the time of MRI-2. Two separate observers subjectively classified the discospondylitis as active or inactive. Repeatability and interobserver agreement were evaluated.ResultsA total of 25 dogs were included. At the time of MRI-2 16 (64%) dogs were asymptomatic and 9 (36%) were symptomatic. Based on MRI-2, 20 (80%) and 18 (72%) out of 25 dogs were considered to have active discospondylitis by the first and second observers, respectively. Interobserver agreement was moderate. No MRI-2 features were associated with the clinical status. The subjective classification of inactive discospondylitis was significantly associated with asymptomatic clinical status, but the classification of active discospondylitis was evenly distributed between groups.ConclusionThis study did not identify a meaningful association between the clinical status of dogs treated for presumptive discospondylitis and MRI-2 results. There were no specific MRI-2 features which were associated with the clinical status.
Assessing Novel Lidar Modalities for Maximizing Coverage of a Spaceborne System through the Use of Diode Lasers
Authors: Hansen Johannes N. , Hancock Steven , Prade Ludwig , Bonner Gerald M. , Chen Haochang , Davenport Ian , Jones Brynmor E. , Purslow Matthew 
Published: May 2022

Current satellite lidars have sparse spatial coverage, leading to uncertainty from sampling. This complicates robust change detection and does not allow applications that require continuous coverage. One potential way to increase lidar sampling density is to use more efficient lasers. All current spaceborne lidars use solid-state lasers with a limited efficiency of 5–8%. In this paper, we investigate the potential for using diode lasers, with their higher efficiencies, as an alternative. Diode lasers have reported efficiencies of about 25% and are much smaller and lighter than solid-state lasers. However, they can only emit good beam quality at lower peak powers, which has so far prevented them from being used in spaceborne lidar applications. In this paper, we assess whether the novel lidar modalities necessitated by these lower peak powers are suitable for satellite lidar, determined by whether they can match the design performance of GEDI by being able to accurately measure ground elevation through 98% canopy cover, referred to as having “98% beam sensitivity”. Through this, we show that a diode laser can be operated in pulse train or pulse compressed lidar (PCL) mode from space, using a photon-counting detector. In the best case scenario, this setup requires a detected energy of Edet=0.027 fJ to achieve a beam sensitivity of 98%, which is less than the 0.28 fJ required by a full-waveform solid-state lidar instrument, exemplified by GEDI. When also accounting for the higher laser and detector efficiency, the diode laser in pulse train mode requires similar shot energy as a photon counting solid-state laser such as ICESat-2 which along with the higher laser efficiency could result in a doubling of coverage. We conclude that there is a clear opportunity for diode lasers to be used in spaceborne lidars, potentially allowing wider coverage through their higher efficiencies.
NUTRITIONAL SILAGE FROM VARIOUS FORAGE CROPS
Authors: ДУБОРЕЗОВ В.М. , ДУБОРЕЗОВ И.В. 
Published: May 2022

В работе представлены результаты исследований по оценке питательности силоса, заготовленного из различных кормовых культур. Установлено, что у силоса, приготовленного из кукурузы и сорго сахарного, переваримость сухого вещества находилась на уровне 63—64,5%. У силоса из подсолнечника она оказалась ниже — 61,2%. Максимальная энергетическая ценность силоса отмечена у раннеспелых гибридов кукурузы — 2,29 МДж ОЭ в натуральном корме и 10,48 МДж ОЭ в сухом веществе. Увеличение высоты среза при уборке среднеранних гибридов повышает энергетическую ценность силоса с 1,96 МДж ОЭ до 2,26 МДж ОЭ. Уборка на силос среднеспелых гибридов кукурузы после заморозков несколько улучшает питательность натурального корма, но снижает концентрацию энергии в сухом веществе с 9,29 до 9,05 МДж ОЭ. Сорго сахарное по выходу питательных веществ с 1 га и концентрации энергии в сухом веществе силоса не уступает кукурузе, а по выходу протеина с 1 га имеет самый высокий показатель — 1028 кг, однако по энергетической ценности (1,86 МДж ОЭ) натуральный корм уступает кукурузному силосу. Подсолнечник из-за высокой влажности имеет низкую питательность силоса — 1,64 МДж ОЭ и наименьший показатель по выходу обменной энергии с 1 га — 61,8 ГДж.
The paper presents the results of the studies conducted in experiments on sheep in the physiological yard, to assess the nutritional value of silage harvested from various fodder crops. It was found that in silage made from corn and sugar sorghum, the digestibility of dry matter was at the level of 63—64.5%. In sunflower silage, it turned out to be lower (about 61.2%). The maximum energy value of silage was noted in early-ripening corn hybrids is 2.29 MJ OE in natural feed and 10.48 MJ OE in soft matter. Increasing the cut height when harvesting mediumearly hybrids increases the energy value of the silo from 1.96 MJ OE to 2.26 MJ OE. Harvesting medium-ripened corn hybrids for silage after freezing slightly increases the nutritional value of natural feed, but reduces the concentration of energy in dry matter from 9.29 to 9.05 MJ OE. Sugar sorghum is not inferior to corn in terms of the yield of nutrients from 1 ha and the energy concentration in the soft matter of the silage, and in terms of protein yield from 1 ha it has the highest index of 1028 kg, however, in terms of energy value (1.86 MJ OE), natural feed is inferior to corn silage. Sunflower, due to high humidity, has a low nutritional value of silage (1.64 MJ OE) and the lowest indicator for the output of exchange energy from 1 hectare (61.8 GJ).
FACTORS INFLUENCING THE ASSESSMENT OF THE BREEDING VALUE OF YOUNG ANIMALS TESTED BY THEIR OWN PRODUCTIVITY
Authors: ХАЙНАЦКИЙ В.Ю. 
Published: May 2022

В статье рассмотрен ряд факторов (класс по живой массе при отъеме от матерей и возраст при постановке на контрольное выращивание), оказывающих влияние на уровень продуктивности бычков мясных пород при тестировании по показателям собственной продуктивности и, соответственно, на оценку племенной ценности тестируемых животных. Показано, что для оценки бычков по собственной продуктивности и производителей по качеству потомства следует отбирать животных с хорошим развитием, не ниже второго класса по живой массе. Наилучшие показатели живой массы в возрасте 15 мес и более высокая скорость роста характерны для животных, поставленных на выращивание в возрасте 7 мес. Адаптационный период у них, длящийся 7—8 мес, во время которого наблюдается снижение продуктивности, не учитывается при выращивании. У молодняка в возрасте 8 мес и старше адаптационный период, длительность которого составляет 20—30 дней, входит в контролируемые сроки тестирования, отрицательно сказываясь на величине среднесуточного прироста и, соответственно, на оценке племенной ценности.
The article considers a number of factors (class according to live weight at weaning from mothers and age when sited for control rearing) that affect the level of productivity of beef bulls when tested in terms of their own productivity and, accordingly, the assessment of the breeding value of the tested animals. It has been shown that in order to evaluate bulls by their own productivity and sires by the quality of progeny, animals with good development, not lower than the second class in live weight, should be selected. The best indicators of live weight at the age of 15 months and a higher growth rate are typical for animals raised at the age of 7 months. Their adaptation period lasting 7-8 months, when a decrease in productivity is observed, is not taken into account at rearing. In young animals aged 8 months and older, the adaptation period, the duration of which is 20–30 days, is included in the controlled testing periods, negatively affecting the average daily gain and, accordingly, the assessment of breeding value.
ANALISIS PELAYANAN UNIT PEMBUATAN KARTU KUNING (AK-1) MENGGUNAKAN METODE SERVQUAL PADA DINAS KETENAGAKERJAAN KOTA MEDAN
Authors: Aisyah Siti , Shyntia Dian , WARDANI SUMITA , WIJAYA DEWANTORO RICO 
Published: May 2022

Sesuai dengan pasal 25 ayat 3 kartu kuning (AK-1) adalah kartu tanda bukti pendaftaran pencari kerja. Istilah Kartu kuning (AK-1) ini berasal bentuk kartu tanda bukti pendaftaran pencari kerja yang berwarna kuning. Kartu kuning (AK-1) digunakan oleh para pencari kerja sebagai keterangan bahwa para pencari kerja belum dan sedang mencari kerja. Banyaknya pencari kerja yang tidak diimbangi dengan penempatan kerjanya, sehingga masih adanya pengagguran yang tersisa akibat tidak meratanya penyaluran tenaga kerja dengan banyak nya lowongan yang ada menunjukkan bahwa masih terjadi masalah lain terkait dengan pelayanan kartu kuning (AK-1) pada Dinas Ketenagakerjaan Kota Medan. Selain masalah tersebut, adanya keluhan pemohon tentang sarana dan prasarana yang kurang dalam pelayanan kartu kuning (AK-1) juga menjadi sorotan tersendiri menyangkut kualitas pelayanan kartu kuning (AK-1) yang diberikan oleh Dinas Ketenagakerjaan Kota Medan. Dalam model Servqual, kualitas jasa didefinisikan sebagai penilaian atau sikap global berkenaan dengan superioritas suatu jasa. Penillaian kualitas pelayanan perlu dilakukan untuk mengetahui bagimana kualitas pelayanan unit pembuatan kartu kuning (AK-1) pada Dinas Ketenagakerjaan Kota Medan. Peningkatan kualitas pelayanan yang dilakukan oleh Dinas Ketenagakerjaan Kota Medan dari Gap Servqual sudah baik.
Analisis Rasio Persepsi Konsumen Pada Kualitas Pelayanan Ojek Online Dengan Metode Service Quality
Authors: Harmaja Okta Jaya , Farrona Rio , Siringo Ringo Jaka Tomi Ronaldo , Hutasoit Leo Nardo , Sinurat Stiven Hamonangan , Indra Evta 
Published: May 2022

Untuk memenuhi aktivitas masyarakat yang beragam apalagi dengan jalanan kota-kota besar yang sangat padat dan sering terjadi kemacetan, membuat masyarakat malas menggunakan transportasi pribadi, dengan adanya transportasi online tentunya akan lebih praktis dan mampu memberikan kemudahan bagi masyarakat sebagai alat penunjang dalam membantu aktivitasnya. Metode Servqual merupakan metode yang digunakan untuk mengukur kualitas layanan dari atribut masing-masing dimensi, sehingga akan diperoleh nilai gap (kesenjangan) yang merupakam selisih antara persepsi konsumen terhadap layanan yang telah diterima dengan harapan terhadap yang akan diterima. Dalam perhitungan perbandingan kualitas pelayanan ojek online melalui kusioner sebanyak 130 responden, didapat hasil bahwa dari keempat Ojek Online yang diteliti Grab menempati posisi pertama dengan nilai persentase sebesar 25,56% posisi kedua ditempati oleh Gojek dengan nilai persentase sebesar 25,45% posisi ketiga ditempati oleh Maxim dengan nilai persentase 24,55% dan diposisi keempat ditempati oleh In-Driver dengan nilai persentase 24,43%.