bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicore implementation of a multichannel parallel graphic equalizer
Authors: Belloch Jose A. , Badía José M , León German , Bank Balázs , Välimäki Vesa 
Published: April 2022

AbstractNumerous signal processing applications are emerging on mobile computing systems. These applications are subject to responsiveness constraints for user interactivity and, at the same time, must be optimized for energy efficiency. Many current embedded devices are composed of low-power multicore processors that offer a good trade-off between computational capacity and low power consumption. In this context, equalizers are widely used in multiple mobile-based applications such as “Music streaming” to adjust the levels of bass and treble in sound reproduction. In this study, we evaluate a graphic equalizer from audio, computational capacity, and energy efficiency perspectives, as well as the execution of multiple real-time equalizers running on an embedded quad-core processor of a mobile device. To this end, we experiment with the working frequencies as well as the parallelism that can be extracted from a quad-core ARM Cortex-A57. Results show that using high CPU frequencies and three or four cores, our parallel algorithm is able to equalize more than five channels per watt in real time with an audio buffer of 4096 samples, which implies a latency of 92.8 ms at the standard sample rate of 44.1 kHz.
The Reality of the ‘Publish or Perish’ Concept, Perspectives from the Global South
Authors: Amutuhaire Tibelius 
Published: April 2022

AbstractHistorically, educators in higher education (HE) were expected to educate, generate knowledge, and do community service. With some commentators arguing that an academic must ‘publish or perish’, the expectation to create knowledge through research became overemphasized. The concept is widespread in HE institutions around the world. It aids to keep staff, particularly those in universities, constantly engaged with relevant knowledge works in their fields of expertise. According to this viewpoint, research publications are the most important factor in determining whether an academic or an administrator gets employed, promoted, acknowledged, retained, or not hired. The idea of ‘publish or perish’, on the other hand, is based on the dominant Western knowledge creation realities, which largely misrepresent or ignore African realities. To avoid perpetuating inequalities in academia, it is critical to re-examine how this idea informs knowledge creation in Africa. For example, the enormous number of publications required for one to advance up the academic ladder comes at a hefty cost that is not always feasible to low-paid academics in Africa’s resource-poor countries. This limits promotion of some individuals. Basically, for many Africans, what matters is the information gained, not how many times one’s work is acknowledged in scholarly publications. We need to establish knowledge-creation processes that are tailored to African realities. To that goal, we must strike a balance between having numerous publications with the potential to have an impact on society, given that developing solutions to development concerns appears to be more vital for Africa right now. This paper problematizes the ‘publish or perish’ concept for African academics, especially those intending to make an impact in their society with a purpose of eliminating inequalities in academia.
Chasing a Drunk Robber in Many Classes of Graphs
Authors: Songsuwan Nuttanon , Thongtha Dawud , Kaemawichanurat Pawaton 
Published: April 2022

AbstractA cops and robbers game (CR) on graphs was originated in 1983 by Quilliot and by Nowakowski and Winkler independently. This game has been applied in many problems in the area of theoretical computer science such as information seeking, robot motion planning or network security as evidenced by many conferences and publications. The CR game has also been extensively studied and varied to many versions. In this paper, we focus on CR game under the condition that the robber performs a random walk. Namely, he drunkenly, or randomly, chooses his next move to escape the cop, while the cop plays optimally in order to minimize the expected drunk capture times$${\textit{dct}}(G)$$

dct
(
G
)

of a graph G. We apply the concepts of expected hitting time in Markov Chain and combinatorial technique to find $${\textit{dct}}(G)$$

dct
(
G
)

for graphs G that have been used in many applications which are cycles, complete multipartite graphs, grid graphs and prism graphs.
Infinite diameter confidence sets in Hedges’ publication bias model
Authors: Moss Jonas 
Published: April 2022

AbstractMeta-analysis, the statistical analysis of results from separate studies, is a fundamental building block of science. But the assumptions of classical meta-analysis models are not satisfied whenever publication bias is present, which causes inconsistent parameter estimates. Hedges’ selection function model takes publication bias into account, but estimating and inferring with this model is tough for some datasets. Using a generalized Gleser–Hwang theorem, we show there is no confidence set of guaranteed finite diameter for the parameters of Hedges’ selection model. This result provides a partial explanation for why inference with Hedges’ selection model is fraught with difficulties.
Continuous cropping legumes in semi-arid Southern Africa: Legume productivity and soil health implications
Authors: Jani Arun D. , Motis Timothy N. , Longfellow Joy M. , Lingbeek Brandon J. , D’Aiuto Christopher J. 
Published: April 2022

Abstract
Legume agronomic research in Southern Africa has often focused on integrating legumes into smallholder cereal cropping systems, but there is limited information available on the feasibility and soil health implications of continuous cropping legumes in the region. Continuous legumes may be suitable in areas with large livestock populations where a premium is placed on high-quality forage, or where efforts are underway to reclaim degraded cropland. Our objectives in this study were to (i) evaluate the performance of diverse legumes under continuous cropping and conservation tillage management with no fertility inputs and (ii) assess the response of soil health parameters to continuous legumes in a semi-arid environment. A 4-year study was conducted in Limpopo, South Africa beginning in the 2011–2012 growing season in which 10 legume and fallow treatments were imposed in the same plots for 4 growing seasons. All legumes responded negatively in varying degrees to continuous cropping in terms of biomass and nutrient accumulation. Lablab (Lablab purpureus L.) was the top-performing legume in the study and accumulated 4.5–13 Mg ha−1 of biomass and 153–345, 11–34, and 75–286 kg ha−1 of N, P, and K, respectively. Lablab often outperformed natural fallow, while other legumes generally performed as well as or inferior to natural fallow, depending on species and growing season. Cowpea (Vigna unguiculata Walp) was especially incompatible with continuous cropping and averaged less than 252 kg ha−1 and 2.1 Mg ha−1 of grain and biomass, respectively, from 2012–2013 to 2014–2015. Continuous cropping did not lead to sustained improvements in soil health. By 2014–2015, soil organic matter for all treatments had either declined or resembled baseline values. Rates of potentially mineralizable N in cowpea, lablab, vining mucuna (Mucuna pruriens var. Utilis), natural fallow, and bare ground plots fell by 70–96% during the study. There was also evidence for lower recovery of leached K by legumes compared to natural fallow species. In conclusion, legumes, such as lablab, should be considered as continuous forages on marginal land in areas where high-quality forage is in demand, but continuous cropping legumes without fertility inputs are not an effective strategy for improving soil health on degraded cropland in this semi-arid region of Southern Africa. Future research efforts may focus on the grazing strategies and baling frequencies required to optimize annual biomass accumulation of continuous lablab to meet livestock demand and support smallholder livelihoods.
Plagiarism and English for academic purposes: A research agenda
Authors: Pecorari Diane 
Published: April 2022

AbstractPlagiarism is a consistent source of concern for educators, and particularly so for English for Academic Purposes (EAP) practitioners, whose objective is to equip students for success across the curriculum. Plagiarism has been on the EAP research agenda for some 35 years and remains a topic of considerable research interest. While perceptions of plagiarism have been extensively investigated, a number of questions relating to the prevalence and causes of plagiarism remain unanswered, and solid evidence about effective pedagogical methods is largely lacking. This article outlines directions for future research on the topic and describes specific investigations that could be conducted.
Re-creation and self-creation in temple design
Authors: Hardy Adam 
Published: April 2022

The article discusses an approach taken for the design of a new temple in Karnataka, India, to be built in the medieval ‘Hoysala’ style, which followed the Karnata Dravida tradition of temple architecture. This style is unfamiliar to present-day traditional temple builders in India. The design needs to be based on research into architectural history, of a kind that aims to relive the processes through which temples were designed, assimilating the architectural language and its principles. This kind of architectural history involves re-creation, and this kind of design can contribute to architectural history as ‘design research’.An application of such research is the reconstruction of temple designs from ruins. The temples can potentially be rebuilt, or they can be reconstructed graphically, and presented meaningfully on site. Re-creation of temples through drawing is also a key for understanding canonical Sanskrit texts on architecture. These texts are not illustrated but call for interpretation through drawing. Temple types are typically presented in sequences of evolution from simple to complex forms, one type emanating from another in way reminiscent of how the architectural traditions themselves develop. Texts provide a framework for a design, demanding interpretation, improvisation, and invention. The results are only partly determined by an individual architect, and the framework can stimulate creations that an individual would never have thought of, as if such temples are svayambhu, or ‘self-creating’.A ’svayambhu’ approach has been taken in the design of the new Hoysala temple. No texts survive from the Karnata Dravida tradition, but the surviving creations of that tradition display the emanatory logic of its unfolding. A ‘self-creating’ design for this temple can be achieved by exploring formal possibilities inherent in the tradition and extrapolating a new form, while accommodating ritual and iconographic requirements, and being open to the unexpected.
Circulating microRNAs from early childhood and adolescence are associated with pre-diabetes at 18 years of age in women from the PMNS cohort
Authors: Joglekar Mugdha V. , Kunte Pooja S. , Wong Wilson K.M. , Bhat Dattatray. S. , Satoor Sarang N. , Patil Rohan R. , Karandikar Mahesh S. , Fall Caroline H. D. , Yajnik Chittaranjan S. , Hardikar Anandwardhan A. 
Published: April 2022

AbstractWith type 2 diabetes presenting at younger ages, there is a growing need to identify biomarkers of future glucose intolerance. A high (20%) prevalence of glucose intolerance at 18 years was seen in women from the Pune Maternal Nutrition Study (PMNS) birth cohort. We investigated the potential of circulating microRNAs in risk stratification for future pre-diabetes in these women. Here, we provide preliminary longitudinal analyses of circulating microRNAs in normal glucose tolerant (NGT@18y, N = 10) and glucose intolerant (N = 8) women (ADA criteria) at 6, 12 and 17 years of their age using discovery analysis (OpenArray™ platform). Machine-learning workflows involving Lasso with bootstrapping/leave-one-out cross-validation identified microRNAs associated with glucose intolerance at 18 years of age. Several microRNAs, including miR-212-3p, miR-30e-3p and miR-638, stratified glucose-intolerant women from NGT at childhood. Our results suggest that circulating microRNAs, longitudinally assessed over 17 years of life, are dynamic biomarkers associated with and predictive of pre-diabetes at 18 years of age. Validation of these findings in males and remaining participants from the PMNS birth cohort will provide a unique opportunity to study novel epigenetic mechanisms in the life-course progression of glucose intolerance and enhance current clinical risk prediction of pre-diabetes and progression to type 2 diabetes.
Fluid‐Kinetic Variations in the Storm‐Time Inner Magnetosphere
Authors: Chaston Christopher C. 
Published: April 2022

AbstractStorm‐time broadband electromagnetic field variations along the interface between the dipolar field of the Earth's inner‐magnetosphere and the stretched fields of the plasma‐sheet are decomposed as a superposition of fluid‐kinetic modes. Using model eigen‐vectors operating on the full set of Van Allen Probes fields measurements it is shown how these variations are composed of a broad spectrum of dispersive Alfvén waves with significant spectral energy densities in the fast and slow modes over scales extending into the kinetic range. These modes occupy volumes in ‐space that define the field variations observed at each spacecraft frame frequency (). They are in aggregate not necessarily planar and often comprise filamentary structures with no distinct propagation direction in the perpendicular plane. Within these volumes the characteristic parallel phase speeds of the fast and Alfvénic modes coincide over a broad range of suggestive of coupling/conversion between modes.
Thank You to Our 2021 Peer Reviewers
Authors: Florindo Fabio , Carlton Annmarie G. , D’Odorico Paolo , Duan Qingyun , Halekas Jasper S. , Mollenhauer Gesine , Rohling Eelco J. , Bingham Robert G. , Brodsky Emily E. , Crucifix Michel C. , Gettelman Andrew , Robock Alan 
Published: April 2022

AbstractReviews of Geophysics is the top‐rated journal in Geochemistry and Geophysics (ISI Web of Knowledge category) reflecting the many excellent contributions we received. It is an important milestone achieved with the reviewers' investment of time and effort. Their expertise ensures that the papers published in this journal meet the standards that the research community expects. We sincerely appreciate the time the reviewers spent reading and commenting on manuscripts, and we are very grateful for their willingness and readiness to serve in this role.
Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies
Authors: Nielsen Suzanne , Picco Louisa , Murnion Bridin , Winters Bryony , Matheson Justin , Graham Myfanwy , Campbell Gabrielle , Parvaresh Laila , Khor Kok-Eng , Betz-Stablein Brigid , Farrell Michael , Lintzeris Nicholas , Le Foll Bernard 
Published: April 2022

AbstractCannabinoid co-administration may enable reduced opioid doses for analgesia. This updated systematic review on the opioid-sparing effects of cannabinoids considered preclinical and clinical studies where the outcome was analgesia or opioid dose requirements. We searched Scopus, Cochrane Central Registry of Controlled Trials, Medline, and Embase (2016 onwards). Ninety-two studies met the search criteria including 15 ongoing trials. Meta-analysis of seven preclinical studies found the median effective dose (ED50) of morphine administered with delta-9-tetrahydrocannabinol was 3.5 times lower (95% CI 2.04, 6.03) than the ED50of morphine alone. Six preclinical studies found no evidence of increased opioid abuse liability with cannabinoid administration. Of five healthy-volunteer experimental pain studies, two found increased pain, two found decreased pain and one found reduced pain bothersomeness with cannabinoid administration; three demonstrated that cannabinoid co-administration may increase opioid abuse liability. Three randomized controlled trials (RCTs) found no evidence of opioid-sparing effects of cannabinoids in acute pain. Meta-analysis of four RCTs in patients with cancer pain found no effect of cannabinoid administration on opioid dose (mean difference −3.8 mg, 95% CI −10.97, 3.37) or percentage change in pain scores (mean difference 1.84, 95% CI −2.05, 5.72); five studies found more adverse events with cannabinoids compared with placebo (risk ratio 1.13, 95% CI 1.03, 1.24). Of five controlled chronic non-cancer pain trials; one low-quality study with no control arm, and one single-dose study reported reduced pain scores with cannabinoids. Three RCTs found no treatment effect of dronabinol. Meta-analyses of observational studies found 39% reported opioid cessation (95% CI 0.15, 0.64,I295.5%, eight studies), and 85% reported reduction (95% CI 0.64, 0.99,I292.8%, seven studies). In summary, preclinical and observational studies demonstrate the potential opioid-sparing effects of cannabinoids in the context of analgesia, in contrast to higher-quality RCTs that did not provide evidence of opioid-sparing effects.
Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma
Authors: Odeniyide Patience , Yohe Marielle E. , Pollard Kai , Vaseva Angelina V. , Calizo Ana , Zhang Lindy , Rodriguez Fausto J. , Gross John M. , Allen Amy N. , Wan Xiaolin , Somwar Romel , Schreck Karisa C. , Kessler Linda , Wang Jiawan , Pratilas Christine A. 
Published: April 2022

AbstractActivating RAS mutations are found in a subset of fusion-negative rhabdomyosarcoma (RMS), and therapeutic strategies to directly target RAS in these tumors have been investigated, without clinical success to date. A potential strategy to inhibit oncogenic RAS activity is the disruption of RAS prenylation, an obligate step for RAS membrane localization and effector pathway signaling, through inhibition of farnesyltransferase (FTase). Of the major RAS family members, HRAS is uniquely dependent on FTase for prenylation, whereas NRAS and KRAS can utilize geranylgeranyl transferase as a bypass prenylation mechanism. Tumors driven by oncogenic HRAS may therefore be uniquely sensitive to FTase inhibition. To investigate the mutation-specific effects of FTase inhibition in RMS we utilized tipifarnib, a potent and selective FTase inhibitor, in in vitro and in vivo models of RMS genomically characterized for RAS mutation status. Tipifarnib reduced HRAS processing, and plasma membrane localization leading to decreased GTP-bound HRAS and decreased signaling through RAS effector pathways. In HRAS-mutant cell lines, tipifarnib reduced two-dimensional and three-dimensional cell growth, and in vivo treatment with tipifarnib resulted in tumor growth inhibition exclusively in HRAS-mutant RMS xenografts. Our data suggest that small molecule inhibition of FTase is active in HRAS-driven RMS and may represent an effective therapeutic strategy for a genomically-defined subset of patients with RMS.
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity
Authors: Das Gupta Dennis , Paul Christoph , Samel Nadine , Bieringer Maria , Staudenraus Daniel , Marini Federico , Raifer Hartmann , Menke Lisa , Hansal Lea , Camara Bärbel , Roth Edith , Daum Patrick , Wanzel Michael , Mernberger Marco , Nist Andrea , Bauer Uta-Maria , Helmprobst Frederik , Buchholz Malte , Roth Katrin , Bastian Lorenz , Hartmann Alina M. , Baldus Claudia , Ikuta Koichi , Neubauer Andreas , Burchert Andreas , Jäck Hans-Martin , Klein Matthias , Bopp Tobias , Stiewe Thorsten , Pagenstecher Axel , Lohoff Michael 
Published: April 2022

AbstractThe processes leading from disturbed B-cell development to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) remain poorly understood. Here, we describeIrf4−/−mice as prone to developing BCP-ALL with age.Irf4−/−preB-I cells exhibited impaired differentiation but enhanced proliferation in response to IL-7, along with reduced retention in the IL-7 providing bone marrow niche due to decreased CXCL12 responsiveness. Thus selected, preB-I cells acquiredJak3mutations, probably following irregular AID activity, resulting in malignant transformation. We demonstrate heightened IL-7 sensitivity due toJak3mutants, devise a model to explain it, and describe structural and functional similarities toJak2mutations often occurring in human Ph-like ALL. Finally, targeting JAK signaling with Ruxolitinib in vivo prolonged survival of mice bearing establishedIrf4−/−leukemia. Intriguingly, organ infiltration including leukemic meningeosis was selectively reduced without affecting blood blast counts. In this work, we present spontaneous leukemogenesis following IRF4 deficiency with potential implications for high-risk BCP-ALL in adult humans.
Circulatory amino acid responses to milk consumption in dairy and lactose intolerant individuals
Authors: Prodhan Utpal Kumar , Milan Amber Marie , Shrestha Aahana , Vickers Mark Hedley , Cameron-Smith David , Barnett Matthew Philip Greig 
Published: April 2022

Abstract
Background/objectives
Self-reported digestive intolerance to dairy foods is common. As dairy can be an important source of dietary protein, this study aimed to identify whether milk protein digestion is compromised in individuals with digestive intolerance.

Subjects/methods
Adult women (n = 40) were enroled in this double-blinded, randomised cross-over trial, with digestive symptoms characterised using a lactose challenge and self-reported digestive symptom questionnaire. Participants were classified as either lactose intolerant (LI, n = 10), non-lactose dairy intolerant (NLDI, n = 20) or dairy tolerant (DT, n = 10). In a randomised sequence, participants consumed three different kinds of milk (750 ml); conventional milk (CON), a2 Milk™ (A2M), and lactose-free conventional milk (LF-CON). Circulatory plasma amino acid (AA) concentrations were measured at baseline and every 30 min until 3 h post-ingestion.

Results
In all participants across all milk types, plasma AA concentrations (AUC0-180) increased after milk ingestion with no significant differences in responses observed between milk types or participants (P > 0.05), with the exception of the suppressed lysine response in the DT group following A2M ingestion, relative to the other two groups and milk types (P < 0.05).

Conclusion
Milk protein digestion, as determined by circulatory AAs, is largely unaffected by dairy- and lactose- intolerances.