bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and validation of visual assessment for the severity of lacrimal groove wrinkles in Chinese females
Authors: Tan Yimei , Amano Satoshi , Jiang Yanwen , Chen Yifan , Qiu Yuchen , Gu Jie , Bao Jingling 
Published: November 2022

AbstractObjectiveThis study was undertaken to establish and validate a new wrinkle clinical assessment scale to measure Chinese Han women`s validated lacrimal groove.MethodsThree clinical investigators asked to rate lacrimal groove wrinkles severity one each side for 30 photographic images from 15 subjects. Five‐grade rating scale has been used in this clinical assessment. Scale definitions was standardized by 6 researchers in visual and descriptive formats. Assessments were conducted independently and were repeated after 1 week.ResultsFor 30 photos from 15 subjects, test‐retest of three investigators analyzed by Spearman's correlation were between 0.967 and 0.993 (p < 0.001), and by ICC Cronbach's α were between 0.989 and 0.997 (p < 0.001); intraobserver agreement of three investigators analyzed by Spearman's correlation were between 0.652 and 0.897 (p < 0.001), and by ICC Cronbach's α were between 0.840 and 0.959 (p < 0.001).ConclusionThis lacrimal groove wrinkles visual assessment scale is a valid and reliable instrument for quantitative assessment of China woman skin folds with inter‐ and intraobserver consistency. This assessment scale should prove a useful clinical tool by allowing objective and reproducible grading for assessing the effectiveness of lacrimal groove area.
Microvascular endothelial function following cessation of long‐term oral contraceptive pill use: A case report
Authors: Turner Casey G. , Stanhewicz Anna E. , Nielsen Karen E. , Wong Brett J. 
Published: November 2022

AbstractThe purpose of this case report was to evaluate in vivo endothelial function and nitric oxide (NO)‐dependent vasodilatation before and after the cessation of long‐term (11–12 years) fourth‐generation oral contraceptive pill (OCP) use in one young, healthy and premenopausal woman. This retrospective analysis includes data from six experimental visits: three visits during months 133–144 of fourth‐generation OCP use and three visits 19–22 months after OCP cessation. Endothelium‐dependent and NO‐dependent vasodilatation were assessed in the cutaneous microvasculature using laser‐Doppler flowmetry, a rapid local heating protocol (39°C, 0.1°C/s) and pharmacological perfusion through intradermal microdialysis fibres. The participant had consistent medical history and lifestyle behaviours throughout both hormonal exposures. Data are presented as the mean (SD). Endothelium‐dependent vasodilatation was 42 (10)% of site‐specific maximal cutaneous vascular conductance (CVCmax) during OCP use and 63 (10)%CVCmax after OCP cessation (49% increase). Nitric oxide‐dependent vasodilatation was 70 (5)% contribution of NO during OCP use and 60 (15)%NO after OCP cessation (15% reduction). Baseline blood flow was greater after OCP cessation, but maximal blood flow was reduced. Data from this case report support a substantial increase in cutaneous microvascular endothelial function assessed via local heating after cessation of long‐term use of a fourth‐generation OCP, which does not appear to be attributable to increased NO bioavailability. Overall, these data suggest an improvement in endothelial and microvascular function after the cessation of long‐term use of a fourth‐generation OCP.
Prevalencia y caracterización de los síntomas de la menopausia en mujeres climatéricas del Eje Cafetero (Colombia), 2018-2020
Authors: Espitia De La Hoz Franklin José 
Published: November 2022

Objetivo: determinar la prevalencia y caracterizar los síntomas de la menopausia, en mujeres climatéricas del Eje Cafetero.
Materiales y métodos: estudio de corte transversal; incluyó mujeres mayores de 45 años, residentes en el Eje Cafetero (Colombia), en etapa de climaterio, sexualmente activas y no usuarias de terapia hormonal de la menopausia; entre 2018 y 2020. Se realizó en tres clínicas privadas, de alta complejidad, en las ciudades de Manizales, Pereira y Armenia. Se aplicaron como instrumentos el índice de Kupperman, y el Menopause-Specific Quality of Life questionnaire (MENQOL). Se realizó un muestreo no probabilístico por conveniencia.
Resultados: 594 mujeres participaron, con edad promedio de 49,28 ± 6,17 años. Edad media de la menopausia 48,71 ± 4,93 años. La prevalencia de los síntomas de la menopausia fue 71,88 %. La mayoría de las mujeres presentaron sofocos (71,88 %), seguida de irritabilidad (63,13 %) e insomnio (54,88 %). La puntuación del índice de Kupperman en la población total fue 18,58 ± 7,61 puntos. Según el MENQOL los mayores promedios pertenecen a las dimensiones vasomotoras (7,13 ± 2,54) y psicosocial (6,48 ± 2,17); con afectación de la calidad de vida del 68,85 %.
Conclusiones: las mujeres climatéricas del Eje Cafetero, presentaron una prevalencia de síntomas de la menopausia próxima a las tres cuartas partes de las participantes, caracterizados principalmente por sofocos e irritabilidad. La mala calidad de vida se atribuye a los síntomas vasomotores. Se hace necesario explorar el impacto del síndrome climatérico durante la atención médica, a fin de ofrecer oportunas soluciones.
Buen morir en la persona mayor:
Authors: Mejía Grueso Andrea , Ramírez Pazos Jerónimo , Roldán Bernal María Camila , López Sanmiguel Andrea , Velásquez Darío Alejandro 
Published: November 2022

El buen morir es un fenómeno que se construye desde múltiples perspectivas de los actores involucrados en la atención del adulto mayor. El objetivo de este trabajo es realizar una revisión temática con análisis cualitativo del contenido 50 artículos relacionados con el buen morir en el adulto mayor publicados en los últimos 10 años. Se encontró que el buen morir carece de una definición universal y está configurada por elementos que varían según el actor involucrado, variables sociodemográficas y aspectos culturales. Visibilizar los elementos más relevantes de lo que configura el buen morir permite ampliar su comprensión, con el objetivo de mejorar la atención en el fin de vida del adulto mayor.
Palabras clave: Anciano, muerte, morir, cuidados paliativos, final de vida
Experimental Force Coefficients for a Fully-Partitioned Pocket Damper Seal and Comparison to Other Two Seal Types
Authors: Delgado Adolfo , San Andrés Luis , Yang Jing , Thiele Jonathan 
Published: November 2022

Abstract
Labyrinth seals (LSs), honeycomb seals (HCSs) and hole-pattern seals, pocket damper seals (PDSs), and fully-partitioned damper seals (FPDSs) serve as balance pistons on the discharge side of barrel-type centrifugal compressors. These seals, facing large pressure differentials along with significant changes in gas density, produce sizeable lateral forces that impact compressor stability and rotordynamic performance. There is extensive archival data on the dynamic forced performance of LS and textured surface seals. However, the experimental database for a FPDS is insufficient, thus a comprehensive comparison of their dynamic force performance against that of textured surface seals is missing. The paper presents experimentally derived rotordynamic force coefficients for a FPDS along with a direct comparison to published data for a HCS and a LS, both similar in size and in operating conditions. The dynamic load tests with the FPDS include operation at a shaft speed (Ω) of 10 krpm (rotor surface speed of 60 m/s) while supplied with air at Pin = 70 bar and Tin =10 °C, and a discharge at Pout = 0.25, 0.5, and 0.65 of Pin. The preswirl circumferential velocity at the seal inlet is low, approximately 6% of rotor surface speed. The FPDS having eight pockets × eight axial blades produces a direct stiffness (K) increasing with excitation frequency (ω), though K &lt; 0 for the lowest pressure ratio PR = (Pout/Pin) = 0.25. The cross-coupled stiffness (k) is invariant to frequency whereas the direct damping (C) steadily decreases as ω/Ω → 1, and then increases for larger frequencies. Hence, the effective damping coefficient (Ceff = C − k/ω) is approximately constant for ω &lt; Ω, while increasing for higher frequencies. For the three PRs, the FPDS leakage is roughly up to 26% larger than the HCS leakage, while the 20-blade LS leaks in between both. The comparison of results shows the LS has insignificant forces compared to those from the HCS and FPDS, both producing a comparable Ceff and similar crossover frequencies (Ceff &gt; 0). The HCS produces a large direct stiffness (K), three to four times that of the FPDS. Comparison of computational fluid dynamics (CFD) predictions for the FPDS against the experimental force coefficients shows significant differences, in particular an overestimation of direct stiffness as the frequency grows along with a lower direct damping for frequencies equal and above the shaft speed. Besides manufacturing considerations, a FPDS is a better alternative to a HCS whose large centering stiffness (K) may affect the compressor's critical speed, hence shortening the separation margin with respect to the operating speed.
Pupil-Aware Holography
Authors: Chakravarthula Praneeth , Baek Seung-Hwan , Schiffers Florian , Tseng Ethan , Kuo Grace , Maimone Andrew , Matsuda Nathan , Cossairt Oliver , Lanman Douglas , Heide Felix 
Published: November 2022

Holographic displays promise to deliver unprecedented display capabilities in augmented reality applications, featuring a wide field of view, wide color gamut, spatial resolution, and depth cues all in a compact form factor. While emerging holographic display approaches have been successful in achieving large étendue and high image quality as seen by a camera, the large étendue also reveals a problem that makes existing displays impractical: the sampling of the holographic field by the eye pupil. Existing methods have not investigated this issue due to the lack of displays with large enough étendue, and, as such, they suffer from severe artifacts with varying eye pupil size and location.
We show that the holographic field as sampled by the eye pupil is highly varying for existing display setups, and we propose pupil-aware holography that maximizes the perceptual image quality irrespective of the size, location, and orientation of the eye pupil in a near-eye holographic display. We validate the proposed approach both in simulations and on a prototype holographic display and show that our method eliminates severe artifacts and significantly outperforms existing approaches.
Could Tierless Languages Reduce IoT Development Grief?
Authors: Lubbers Mart , Koopman Pieter , Ramsingh Adrian , Singer Jeremy , Trinder Phil 
Published: November 2022

Internet of Things (IoT) software is notoriously complex, conventionally comprising multiple tiers. Traditionally an IoT developer must use multiple programming languages and ensure that the components interoperate correctly. A novel alternative is to use a single
tierless
language with a compiler that generates the code for each component and ensures their correct interoperation.

We report a systematic comparative evaluation of two tierless language technologies for IoT stacks: one for resource-rich sensor nodes (Clean with iTask) and one for resource-constrained sensor nodes (Clean with iTask and mTask). The evaluation is based on four implementations of a typical smart campus application: two tierless and two Python-based tiered.
(1) We show that tierless languages have the potential to significantly reduce the development effort for IoT systems, requiring 70% less code than the tiered implementations. Careful analysis attributes this code reduction to reduced interoperation (e.g., two embedded domain-specific languages and one paradigm versus seven languages and two paradigms), automatically generated distributed communication, and powerful IoT programming abstractions. (2) We show that tierless languages have the potential to significantly improve the reliability of IoT systems, describing how Clean iTask/mTask maintains type safety, provides higher-order failure management, and simplifies maintainability. (3) We report the first comparison of a tierless IoT codebase for resource-rich sensor nodes with one for resource-constrained sensor nodes. The comparison shows that they have similar code size (within 7%), and functional structure. (4) We present the first comparison of two tierless IoT languages, one for resource-rich sensor nodes and the other for resource-constrained sensor nodes.
Abstract 223: Modifiable Mesenchymal Stem Cell Defects In Veterans With Diabetes Mellitus
Authors: Hoffmann Carson , Sasaki Maiko , Bitarafan Sara , Jung Yoonhee , McLaughlin Dylan , Li Feifei , Corces Victor , Wood Levi , Brewster Luke 
Published: November 2022

Diabetes Mellitus (DM) affects 34.2 million Americans. DM impairs the body’s reparative machinery leading to early onset chronic illness (peripheral arterial disease (PAD), neuropathy, nephropathy, and retinopathy, the latter being hallmarks of microvascular disease). Patients with DM+PAD have increased risk of major amputation. Mesenchymal stem cells (MSCs) are reparative cells found in all tissues providing paracrine and trophic support for new tissue. This study’s objective was to identify intracellular and epigenetic mechanisms of how DM impairs MSC function and test if these defects are modifiable with culture rejuvenation (CR).
MSCs obtained from bone marrow of 13 consecutive, male Veterans undergoing lower limb major amputation were cultured in 10% fetal bovine serum or 5% human platelet lysate (PL) for CR. Groups were DM+PAD (n=8) and PAD no DM (n=5). Intracellular signaling was analyzed with multiplexed ELISA. Epigenetic differences were identified by ATAC-sequencing.
DM+PAD MSCs had modifiable AKT signaling defects with PL (Fig 1) and a discrete DNA profile identified in their introns and intergenic regions (Fig 2). MSCs from PAD alone had increased transcription factor binding at Wnt and cGMP-PKG pathways (p=0.04). DM+PAD MSCs had increased binding at MAPK (p=0.01) and Rap1 (p=0.01) pathways.
DM is a complex disease disrupting reparative mechanisms and can lead to major complications. MSC dysfunction in DM may have common mechanisms throughout the body. We have identified potentially druggable pathways that may provide therapeutic solutions to relieve chronic illness for endogenous MSCs and to expand MSC donor pool for regenerative medicine strategies.
Praliciguat Promotes Ischemic Leg Reperfusion in Leptin Receptor-Deficient Mice
Authors: Foussard Ninon , Rouault Paul , Cornuault Lauriane , Reynaud Annabel , Buys Emmanuel S. , Chapouly Candice , Gadeau Alain-Pierre , Couffinhal Thierry , Mohammedi Kamel , Renault Marie-Ange 
Published: November 2022

Background:
Lower-limb peripheral artery disease is one of the major complications of diabetes. Peripheral artery disease is associated with poor limb and cardiovascular prognoses, along with a dramatic decrease in life expectancy. Despite major medical advances in the treatment of diabetes, a substantial therapeutic gap remains in the peripheral artery disease population. Praliciguat is an orally available sGC (soluble guanylate cyclase) stimulator that has been reported both preclinically and in early stage clinical trials to have favorable effects in metabolic and hemodynamic outcomes, suggesting that it may have a potential beneficial effect in peripheral artery disease.

Methods:

We evaluated the effect of praliciguat on hind limb ischemia recovery in a mouse model of type 2 diabetes. Hind limb ischemia was induced in leptin receptor-deficient (Lepr

db/db

) mice by ligation and excision of the left femoral artery. Praliciguat (10 mg/kg/day) was administered in the diet starting 3 days before surgery.

Results:

Twenty-eight days after surgery, ischemic foot perfusion and function parameters were better in praliciguat-treated mice than in vehicle controls. Improved ischemic foot perfusion was not associated with either improved traditional cardiovascular risk factors (ie, weight, glycemia) or increased angiogenesis. However, treatment with praliciguat significantly increased arteriole diameter, decreased ICAM1 (intercellular adhesion molecule 1) expression, and prevented the accumulation of oxidative proangiogenic and proinflammatory muscle fibers. While investigating the mechanism underlying the beneficial effects of praliciguat therapy, we found that praliciguat significantly downregulated
Myh2
and
Cxcl12
mRNA expression in cultured myoblasts and that conditioned medium form praliciguat-treated myoblast decreased
ICAM1
mRNA expression in endothelial cells. These results suggest that praliciguat therapy may decrease
ICAM1
expression in endothelial cells by downregulating
Cxcl12
in myocytes.

Conclusions:
Our results demonstrated that praliciguat promotes blood flow recovery in the ischemic muscle of mice with type 2 diabetes, at least in part by increasing arteriole diameter and by downregulating ICAM1 expression.
The role of acid phosphatase during sucking blood of Haemaphysalis longicornis
Authors: WANG KUANG , GAO ZHIHUA , ZHANG SONGBO , SHI YANQING , DONG KEXIN , LV WENXIA , YANG XIAOLONG 
Published: November 2022

In this study, a novel acid phosphatase was isolated from Haemaphysalis longicornis which may affect the reproductive development of the tick. The gene was isolated from a cDNA library named HLACP and analyzed by bioinformatics. Then, the spatial and temporal expression patterns of the genes were analyzed by real-time PCR. In addition, combined with RNAi interference platform and protein modification omics, the changes of protein expression and modification level of H. longicornis before and after blood feeding were analyzed after interference with HLACP.
Monitoring mites in orchards: absence or non-detection?
Authors: RAHMANI HASAN , LEFOE GREG , KWONG RAELENE 
Published: November 2022

Successful integrated pest management (IPM) programs rely on effective and efficient methods of monitoring pest and beneficial species, including mites. Several methods have been proposed for monitoring mites in Australian orchards, mainly based on examining leaves in situ. During the 2021–2022 growing season we flagged 1–2 pear trees Pyrus communis in each of 192 panels (a panel being trees in a 14 m length of a row) in a pear orchard at Tatura, Victoria, Australia. For each flagged tree we examined mite species occurrence and prevalence using three methods, (1) non-destructive visual examination of 10 leaves per panel using a 10x hand lens (current industry standard), (2) destructive lab-based examination of 4 leaves per flagged tree(s) using a stereo microscope, and (3) destructive lab-based examination of 2 leaves per flagged tree(s) using a stereo microscope. The presence and prevalence of pest mites and the previously released predatory mite Neoseiulus californicus were recorded. Throughout the season we observed various pest mites in the orchard including Tetranychus urticae, Panonychus ulmi, Eriophyes pyri, and Bryobia rubrioculus and the predatory mite N. californicus. However, the number of species detected and the prevalence of detected species on leaves were dependant on sampling method used. Both destructive sampling methods, method (2) and method (3), performed better than the current non-destructive industry standard in terms of species detection and prevalence. The largest differences were seen during the early stages of infestation for mite species other than E. pyri. Early detection of certain mite species is important because it can provide a more accurate estimate of the starting point for Cumulative Leaf Infested Days (CLIDs) calculations, resulting in better informed management decisions. Importantly, detection and prevalence results were similar for methods (2) and (3) despite the greatly reduced sampling effort (time required) for method (3), and overall sampling effort for method (3) was similar to that required for method (1). Therefore, in terms of both accuracy and sampling effort, method (3) outperformed the other two methods we trialled. An obvious limitation of method (3) when compared to current practice is the requirement for a stereo microscope and access to a laboratory or similar facility. Therefore, the method may be more useful for appropriately trained consultants who monitor pests in orchards on behalf of growers. Another limitation with our study was that it was limited to a single growing season in one pear orchard. We therefore recommend further research to validate our observations, and to support recommendations for growers and consultants.
Restoring management practices in Tuscan organic vineyards and impact on soil mesostigmatid mites
Authors: GAGNARLI ELENA , COSTANTINI EDOARDO A. , PRIORI SIMONE , VALBOA GIUSEPPE , PELLEGRINI SERGIO , VIGNOZZI NADIA , AGNELLI ALESSANDRO E. , GOGGIOLI DONATELLA , GUIDI SILVIA , LANDI SILVIA , D’ERRICO GIADA , SIMONI SAURO 
Published: November 2022

Soil fauna actively contributes to drive crucial processes of energy and nutrient cycling in agricultural systems, to influence the quality of crops and pest incidence. Soil tillage can be absolutely considered as one of the most influential agricultural manipulations of soil structure and has a profound influence on soil biology and its provision of ecosystem services. Understanding the effects of different tillage intensities is of interest not only to the scientific community but also to farmers, practitioners, policymakers, and agricultural consultants. As the long-term evidence in degraded vineyard soils, EU and FAO highly recommend inter-row practices basing on sustainable managements and good agronomic practices (GAPs) to re-install soil functionality. In this study, we aimed at evaluating effects of different GAP practices that can improve soil recovering on some soil quality indicators, with emphasis to edaphic mesostigmatid mites.
Impacts of continental invasion of Raoiella indica in the Americas
Authors: RODRIGUES JOSE CARLOS VERLE , OCHOA RONALD , CARRILLO DANIEL 
Published: November 2022

The invasion of the Red Palm Mite (RPM), Raoiella indica, in the western hemisphere, is probably the most extensive, fastest, and better-documented plant pest arthropod invasion in recent decades. RPM was initially detected in the Lesser Caribbean Antilles, and it rapidly spread hooping through the islands and reaching continental areas in North, Central and South America.
Spit it out: extraction of saliva from the lychee erinose mite (Aceria litchi (Keifer) Acari: Eriophyidae)
Authors: DE GIOSA MARCELLO , ATAIDE LIVIA M. S. , OCHOA RONALD , DE LILLO ENRICO , CARRILLO DANIEL , REVYNTHI ALEXANDRA M. 
Published: November 2022

The Lychee Erinose Mite (LEM) (Aceria litchii (Keifer)) is a gall-making eriophyid that feeds exclusively on lychee trees (Litchi chinensis Sonnerat), inducing the development of open leaf galls called erinea. Erinea are structures formed of hypertrophic leaf trichomes where LEM seeks refuge, feeds and reproduces.
Our life companions: the human follicular mite Demodex folliculorum
Authors: PEROTTI M. ALEJANDRA , BRAIG HENK R. 
Published: November 2022

We carry them in our skin pores through our entire life, from birth to death. We offer them shelter and in return, they tidy-up our pores. We go on with our busy day life and they sleep. They wake up when we go to sleep and while we are deeply dreaming, they move around, visit other pores and mates, and reproduce. Despite being our ‘very own’ life companions, until recently, we knew very little about their struggle.