bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leukemia/lymphoma oral infiltration and its impact on disease outcomes: A Brazilian study
Authors: de Sena Ana Carolina Velasco Pondé , de Arruda José Alcides Almeida , Bemquerer Larissa Marques , Pantuzzo Erika Soares , Kakehasi Fabiana Maria , Fonseca Felipe Paiva , Fournier Benjamin P. J. , Abreu Lucas Guimarães , Travassos Denise Vieira , Silva Tarcília Aparecida 
Published: November 2022

AbstractObjectiveOral malignant infiltrations (OMI) are relevant for the diagnosis and prognosis of leukemia/lymphoma. This study analysed the oral health status and OMI of individuals with leukemia/lymphoma.Materials and MethodsA retrospective analysis (2010–2021) of data from individuals seen at a specialized hospital‐based dental service in Brazil.ResultsA total of 781 cases of leukemia/lymphoma were surveyed. Acute lymphoblastic leukemia (30.1%), acute myeloid leukemia (AML; 26.0%), and non‐Hodgkin lymphoma (22.2%) were the most common diagnoses. The first (21.3%) and second (19.3%) decades of life were the most affected. Overall, dental caries (36.7%) and periodontal changes (34.6%) were the most frequent oral conditions. OMI occurred in 25 (3.2%) individuals. Lesions mainly involved the gingiva (80%) and patients diagnosed with AML (64%). Death (p < 0.001) and worse periodontal condition (p = 0.036) were more frequent among adults with OMI than among those without OMI. Death (p = 0.002) was more frequent among paediatric individuals with OMI than among those without OMI. When controlling for underlying disease, no association was observed between OMI and these outcomes.ConclusionOral status of individuals with leukemia, particularly those with acute leukemia or lymphoma, should be closely monitored since one or multiple conditions may occur, including OMI, which may influence disease outcomes.
EPFL peptide signalling ensures robust self‐pollination success under cool temperature stress by aligning the length of the stamen and pistil
Authors: Negoro Satomi , Hirabayashi Tomo , Iwasaki Rie , Torii Keiko U. , Uchida Naoyuki 
Published: November 2022

AbstractSuccessful sexual reproduction of plants requires temperature‐sensitive processes, and temperature stress sometimes causes developmental asynchrony between male and female reproductive tissues. In Arabidopsis thaliana, self‐pollination occurs when the stamen and pistil lengths are aligned in a single flower so that pollens at the stamen tip are delivered to the stigma at the pistil tip. Although intercellular signalling acts in several reproduction steps, how signalling molecules, including secreted peptides, contribute to the synchronous growth of reproductive tissues remains limited. Here, we show that the mutant of the secreted peptide EPIDERMAL PATTERNING FACTOR LIKE 6 (EPFL6), which shows no phenotypes at a moderate temperature, fails in fruit production at a cool temperature due to insufficient elongation of stamens. EPFL6 is expressed in stamen filaments and promotes filament elongation to achieve the alignment of stamen and pistil lengths at a cool temperature. We also found that, at a moderate temperature, all EPFL6‐subfamily genes are required for stamen elongation. Furthermore, we showed that ERECTA (ER), known as a common receptor for EPFL‐family peptides, mediates the stamen–pistil growth coordination. Lastly, we provided evidence that modulation of ER activity rescues the reproduction failure caused by insufficient stamen elongation by realigning the stamen and pistil lengths.
Performance Prediction Method for Forward Variable Area Bypass Injector of Variable Cycle Engine Based on Numerical Simulation
Authors: Zhen Man , Dong Xue-zhi , Zheng Jun-chao , Liu Xi-yang , Tan Chun-qing 
Published: November 2022

Abstract
As an evolutional concept of aero engine, the variable cycle engine (VCE) can adjust the thermodynamic cycle via working on different modes to meet different flight missions. These working modes lead to the performance and stability of variable geometries for mode switching under different mission profiles. This paper aims at the performance prediction under different working conditions on the key variable geometry, namely, the forward variable area bypass injector (FVABI). The rotary and translating mathematical calculation models are established and validated via the three-dimensional numerical simulation. It considers the choked flow state caused by area change at FVABI and mode selector valve (MSV). The variable geometry schedules at the typical subsonic cruise working condition are analyzed based on the zero-dimensional engine performance model. It verifies the efficiency of the improved zero-dimensional bypass mixing calculation model to predict the mixing characteristics of the FVABI on different operating modes. The maximum error of the total pressure recovery coefficient and the ejection ratio is 2.3% and 6.2%, respectively. This performance prediction method can lay foundations for the variable geometry design and performance optimization of the VCE under typical mission profiles.
Design of a Novel Tendon-Sheath-Driven Upper Limb Exoskeleton for Assisting Surgeon Performing Microlaryngoscopic Surgery
Authors: Wang Zhengyu , Song Wenjun , Qian Sen , Wang Daoming , Jia Zirui , Yu Xiang 
Published: November 2022

Abstract
Microlaryngoscopic surgery is a type of laryngeal surgery performed by surgeons using microsurgical instruments under the observation of a specially designed laryngoscope. While performing a microlaryngoscopic operation, the surgeons must maintain their arms' position for a long time, which can cause arms' soreness and affect the accuracy of the operation. In this study, a tendon-sheath-driven upper limb auxiliary exoskeleton (TULAE) is proposed and developed. The flexible cables are compressed by a wave-shaped pressing mechanism to fix the TULAE's rotating joints. The TULAE can assist surgeons in laryngoscopy operations by providing suitable support for their arms to reduce the surgical risks caused by muscle fatigue. The TULAE has four degrees-of-freedom (DOFs) on each arm. The shoulder flexion/extension, shoulder abduction/adduction, and elbow internal rotation/external rotation can be fixed by the control box. The shoulder internal rotation/external rotation is a passive DOF obtained using hinges. The TULAE's shoulder, upper arm and forearm links are designed with lengths adjustable to accommodate wearers of different heights and weights. A large-scale but risk-free workspace is analyzed through rigid body kinematics using the spinor method. The control hardware of the TULAE is developed based on the open-source Arduino board. Finally, the experimental results show that this TULAE can significantly reduce the range of wrists shaking and assist surgeons in laryngoscopy surgery.
Synthetic Fault Mode Generation for Resilience Analysis and Failure Mechanism Discovery
Authors: Hulse Daniel , Irshad Lukman 
Published: November 2022

AbstractTraditional risk-based design processes seek to mitigate operational hazards by manually identifying possible faults and devising corresponding mitigation strategies—a tedious process which critically relies on the designer’s limited knowledge. In contrast, resilience-based design seeks to embody generic hazard-mitigating properties in the system to mitigate unknown hazards, often by modelling the system’s response to potential randomly generated hazardous events. This work creates a framework to adapt these scenario generation approaches to the traditional risk-based design process to synthetically generate fault modes by representing them as a unique combination of internal component fault states, which can then be injected and simulated in a model of system failure dynamics. Based on these simulations, the designer may then better understand the underlying failure mechanisms and mitigate them by design. The performance of this approach is evaluated in a model of an autonomous rover, where cluster analysis shows that elaborating the faulty state-space in the drive system uncovers a wider range of possible hazardous trajectories and failure consequences within each trajectory than would be uncovered from manual mode identification. However, this increase in hazard information gained from exhaustive mode sampling comes at a high computational expense, highlighting the need for advanced, efficient methods to search and sample the faulty state-space.
Impact of community asymptomatic rapid antigen testing on covid-19 related hospital admissions: synthetic control study
Authors: Zhang Xingna , Barr Ben , Green Mark , Hughes David , Ashton Matthew , Charalampopoulos Dimitrios , García-Fiñana Marta , Buchan Iain 
Published: November 2022

Abstract

Objective
To analyse the impact of voluntary rapid testing for SARS-CoV-2 antigen in Liverpool city on covid-19 related hospital admissions.

Design
Synthetic control analysis comparing hospital admissions for small areas in the intervention population with a group of control areas weighted to be similar for past covid-19 related hospital admission rates and sociodemographic factors.

Setting
Liverpool city, UK, 6 November 2020 to 2 January 2021, under the intervention of Covid-SMART (systematic meaningful asymptomatic repeated testing) voluntary, open access supervised self-testing with lateral flow devices, compared with control areas selected from the rest of England.

Population
General population of Liverpool (n=498 042) and a synthetic control population from the rest of England.

Main outcome measure
Weekly covid-19 related hospital admissions for neighbourhoods in England.

Results
The introduction of community testing was associated with a 43% (95% confidence interval 29% to 57%) reduction (146 (96 to 192) in total) in covid-19 related hospital admissions in Liverpool compared with the synthetic control population (non-adjacent set of neighbourhoods with aggregate trends in covid-19 hospital admissions similar to Liverpool) for the initial period of intensive testing with military assistance in national lockdown from 6 November to 3 December 2020. A 25% (11% to 35%) reduction (239 (104 to 333) in total) was estimated across the overall intervention period (6 November 2020 to 2 January 2021), involving fewer testing centres, before England’s national roll-out of community testing, after adjusting for regional differences in tiers of covid-19 restrictions from 3 December 2020 to 2 January 2021.

Conclusions
The city-wide pilot of community based asymptomatic testing for SARS-CoV-2 was associated with substantially reduced covid-19 related hospital admissions. Large scale asymptomatic rapid testing for SARS-CoV-2 could help reduce transmission and prevent hospital admissions.
Cervical sympathectomy to treat cerebral vasospasm: a scoping review
Authors: Bombardieri Anna Maria , Heifets Boris D , Treggiari Miriam , Albers Gregory W , Steinberg Gary K , Heit Jeremy J 
Published: November 2022

Background/ImportanceDelayed cerebral ischemia (DCI) is the second-leading cause of death and disability in patients with aneurysmal subarachnoid hemorrhage (aSAH), and is associated with cerebral arterial vasospasm (CAV). Current treatments for CAV are expensive, invasive, and have limited efficacy. Cervical sympathetic block (CSB) is an underappreciated, but potentially highly effective therapy for CAV.ObjectiveTo provide a comprehensive review of the preclinical and human literature pertinent to CSB in the context of CAV.Evidence reviewThis study followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. We conducted a literature search using Embase, PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Scopus and Web of Science until February 2022, to identify abstracts, conference proceedings, and full-text papers pertinent to cervical sympathectomy and CAV in animal/adult patients.FindingsWe included six human and six experimental studies. Human studies were mostly prospective observational, except one retrospective and one randomized clinical trial, and used various imaging modalities to measure changes in arterial diameter after the block. Studies that used digital subtraction angiography showed an improvement in cerebral perfusion without change in vessel diameter. Transcranial Doppler studies found an approximately 15% statistically significant decrease in velocities consistent with arterial vasodilatation. Overall, the results suggest an increase in cerebral arterial diameter and neurological improvement in patients receiving a CSB. Animal studies demonstrate that sympathetic system ablation vasodilates cerebral vasculature and decreases the incidence of symptomatic vasospasm.ConclusionsThis scoping review suggests that CSB may be a viable option for treatment and prevention of CAV/DCI in patients with aSAH, although the included studies were heterogeneous, mostly observational, and with a small sample size. Further research is needed to standardize the technique and prove its effectiveness to treat patients suffering of CAV/DCI after aSAH.
Synthesis of a π-extended azacoronene composed of naphthalene and acenaphtho[1,2-c]pyrrole toward a chiral curved π structure
Authors: Takase Masayoshi , Matsunaga Takayuki , Oki Kosuke , Mori Shigeki , Uno Hidemitsu 
Published: November 2022

[Formula: see text]-Extended azacoronene has been synthesized via an S[Formula: see text]Ar reaction using acenaphthopyrrole and octafluoronaphthalene utilizing successive Scholl reactions. Although the chiral conformers could not be isolated, the new azacoronene analog exhibited longer-wavelength absorption and reversible oxidation properties, which are characteristic of pyrrole-fused azacoronenes. When combined with the results of our DFT calculations, the experimental results indicate weaker global aromaticity than that of previously reported azacoronenes.
Chapter 2. Sequence stratigraphic concepts and methodologies
Authors: Copestake Philip 
Published: November 2022

Abstract
This chapter reviews sequence stratigraphic concepts and methodologies and presents an approach that is most applicable to the North Sea Jurassic, based on the concept of genetic sequence stratigraphy. The concept of depositional sequences, comprising rock units bounded by unconformities, has been developed from the late nineteenth century up to the present day. Many different studies have been carried out on North Sea Jurassic sequence stratigraphy, from the early 1980s to the present day and involving a range of different approaches. Many authors have adopted the J sequence approach that was first published in the early 1990s; however, a number of alternative North Sea Jurassic sequence schemes have also been described. A close relationship existed between tectonics and sequence boundary development, particularly during the Middle–Late Jurassic in the North Sea region. Several of the major unconformities that are known to be of regional extent can be directly related to significant tectonic phases. Other sequence boundaries, for which a tectonic control is not evident, for example, particularly in the Early Jurassic, were potentially driven by glacio-eustatic cycles, which may have been controlled by orbital forcing cycles.
Chapter 3. Sequence stratigraphy scheme for the Lower Jurassic of the North Sea area
Authors: Copestake Philip , Partington Mark A. 
Published: November 2022

Abstract
This chapter describes Lower Jurassic second-order sequences J00 and J10, and their component third-order sequences J1–J6 and J12–J18. Two sequences (J1 and J3) are new, four sequences (J2, J4, J12 and J16) are amended and one sequence (J17) is renamed.
A significant unconformity at the base of the J12 sequence (Upper Sinemurian) is present near the base of the Dunlin Group in the North Viking Graben–East Shetland Platform and in the Danish Central Graben, and correlates with an equivalent unconformity around the margins of the London Platform, onshore UK. A marked unconformity at the base of the J16 sequence is recognized in the North Viking Graben and onshore UK, where it is related to structural movements on the Market Weighton High, eastern England.
Several levels of carbon enrichment (carbon isotope excursions (CIEs)) and associated geochemical changes tie to J sequences defining maximum flooding surfaces: the Upper Sinemurian CIE equates to the base J6 maximum flooding surface (MFS), the basal Pliensbachian CIE ties to the base J13 MFS, the basal Toarcian CIE relates to the base J17 MFS and the Toarcian Ocean Anoxic Event corresponds with the base J18 MFS.
T-orbit spaces of multiplicative actions and applications
Authors: Hubert Evelyne , Metzlaff Tobias , Moustrou Philippe , Riener Cordian 
Published: November 2022

We present the results of our recent article [4] and discuss its applications [5]. A finite group with an integer representation has a multiplicative action on the ring of Laurent polynomials, which is induced by a nonlinear action on the compact torus. We study the structure of the orbit space as the image of the fundamental invariants. For the Weyl groups associated to crystallographic root systems of types A, B, C, D, this image is a compact basic semi-algebraic set. We give the defining polynomial inequalities explicitly as the positivity-locus of a Hermite matrix polynomial.
As an application, we consider the problem of computing the optimal value of an exponential function and solve it with algebraic methods under symmetry assumptions.
Quantum Teleportation Error Suppression Algorithm Based on Convolutional Neural Networks and Quantum Topological Semion Codes
Authors: Cao Qian , Wang Hao-Wen , Qu Ying-Jie , Xue Yun-Jia , Wang Shu-Mei 
Published: November 2022

Quantum error correction (QEC) is a key technique for building scalable quantum computers that can be used to mitigate the effects of errors on physical quantum bits. Since quantum states are more or less affected by noise, errors are inevitable. Traditional QEC codes face huge challenges. Therefore, designing an error suppression algorithm based on neural networks (NN) and quantum topological error correction (QTEC) codes is particularly important for quantum teleportation. In this paper, QTEC codes: semion codes—a greater than 2 dimensional (2D) error correction code based on the double semion model—are used to suppress errors during quantum teleportation, using a NN to build a decoder based on semion codes and to simulate the quantum information error suppression process and the suppression effect. The proposed convolutional neural network (CNN) decoder is suitable for small distance topological semion codes. The aim is to optimize the NN for better decoder performance while deriving the relationship between decoder performance and slope and pseudothreshold during training and calculate the thresholds for different noise areas when the code distances are the same,

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Learning With Proper Partial Labels
Authors: Wu Zhenguo , Lv Jiaqi , Sugiyama Masashi 
Published: November 2022

AbstractPartial-label learning is a kind of weakly supervised learning with inexact labels, where for each training example, we are given a set of candidate labels instead of only one true label. Recently, various approaches on partial-label learning have been proposed under different generation models of candidate label sets. However, these methods require relatively strong distributional assumptions on the generation models. When the assumptions do not hold, the performance of the methods is not guaranteed theoretically. In this letter, we propose the notion of properness on partial labels. We show that this proper partial-label learning framework requires a weaker distributional assumption and includes many previous partial-label learning settings as special cases. We then derive a unified unbiased estimator of the classification risk. We prove that our estimator is risk consistent, and we also establish an estimation error bound. Finally, we validate the effectiveness of our algorithm through experiments.
How Accurately Can Warm Rain Realistically Be Retrieved with Satellite Sensors? Part II: Horizontal and Vertical Heterogeneities
Authors: Schulte Richard M. , Kummerow Christian D. , Saleeby Stephen M. , Mace Gerald G. 
Published: November 2022

Abstract
There are many sources of uncertainty in satellite precipitation retrievals of warm rain. In this paper, the second of a two-part study, we focus on uncertainties related to spatial heterogeneity and surface clutter. A cloud-resolving model simulation of warm, shallow clouds is used to simulate satellite observations from three theoretical satellite architectures—one similar to the Global Precipitation Measurement Core Observatory, one similar to CloudSat, and one similar to the planned Atmosphere Observing System (AOS). Rain rates are then retrieved using a common optimal estimation framework. For this case, retrieval biases due to nonuniform beamfilling are very large, with retrieved rain rates negatively (low) biased by as much as 40%–50% (depending on satellite architecture) at 5 km horizontal resolution. Surface clutter also acts to negatively bias retrieved rain rates. Combining all sources of uncertainty, the theoretical AOS satellite is found to outperform CloudSat in terms of retrieved surface rain rate, with a bias of −19% as compared with −28%, a reduced spread of retrieval errors, and an additional 17.5% of cases falling within desired uncertainty limits. The results speak to the need for additional high-resolution modeling simulations of warm rain so as to better characterize the uncertainties in satellite precipitation retrievals.
A Cloud-Controlling Factor Perspective on the Hemispheric Asymmetry of Extratropical Cloud Albedo
Authors: Blanco Joaquín E. , Caballero Rodrigo , Datseris George , Stevens Bjorn , Bony Sandrine , Hadas Or , Kaspi Yohai 
Published: November 2022

Abstract
The Northern and Southern Hemispheres reflect on average almost equal amounts of sunlight due to compensating hemispheric asymmetries in clear-sky and cloud albedo. Recent work indicates that the cloud albedo asymmetry is largely due to clouds in extratropical oceanic regions. Here, we investigate the proximate causes of this extratropical cloud albedo asymmetry using a cloud-controlling factor (CCF) approach. We develop a simple index that measures the skill of CCFs, either individually or in combination, in predicting the asymmetry. The index captures the contribution to the asymmetry due to interhemispheric differences in the probability distribution function of daily CCF values. Cloud albedo is quantified using daily MODIS satellite retrievals, and is related to range of CCFs derived from the ERA5 product. We find that sea surface temperature is the CCF that individually explains the largest fraction of the asymmetry, followed by surface wind. The asymmetry is predominantly due to low clouds, and our results are consistent with prior local-scale modeling work showing that marine boundary layer clouds become thicker and more extensive as surface wind increases and surface temperature cools. The asymmetry is consistent with large-scale control of storm-track intensity and surface winds by meridional temperature gradients: persistently cold and windy conditions in the Southern Hemisphere keep cloud albedo high year-round. Our results have important implications for global-scale cloud feedbacks and contribute to efforts to develop a theory for planetary albedo and its symmetry.