bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinically Relevant Deficits in Performance Tests in Patients With Axial Spondyloarthritis
Authors: Kiltz Uta , Ahomaa Eerik , van Weely Salima F.E. , Kiefer David , Bühring Bjoern , Baraliakos Xenofon , Braun Jürgen 
Published: September 2022

ObjectiveTo assess the association between self-reported and performance-based physical functioning and to evaluate which performance tests are most frequently impaired in patients with axial spondyloarthritis (axSpA).MethodsConsecutive patients with axSpA underwent standardized assessments including patient and disease characteristics; patient-reported outcomes for disease activity, functioning, depression, mobility, and physical activity; and performance tests. Patients were defined as being impaired if they were not able to perform ≥ 1 of the performance tests. Validated cut-offs were used to define impaired physical performance. Impairment of performance tests as well as discrimination between subgroups were analyzed.ResultsA total of 200 patients (radiographic axSpA 66.5%, nonradiographic axSpA 33.5%) were included: 69% males, mean age 44.3 (SD 12.5) years, and mean symptom duration 17.9 (SD 12.6) years. The 2 most frequently impaired performance tests were the repeated chair stand test (n = 75, 37.5%) and putting on socks (n = 44, 22%). An impairment in ≥ 1 performance test was seen in 91 patients (45.5%). Patients with impairments were older (49.1 yrs vs 40.3 yrs); had a higher BMI (28.9 kg/m2vs 25.8 kg/m2); a more active disease (Ankylosing Spondylitis Disease Activity Score, 3.0 vs 2.1); higher Bath Ankylosing Spondylitis Functional Index (BASFI; 5.8 vs 2.7), Bath Ankylosing Spondylitis Metrology Index (BASMI; 4.4 vs 2.7), and Assessment of Spondyloarthritis international Society Health Index scores (9.5 vs 4.9); and higher depression screen values (9-item Patient Health Questionnaire, 11.6 vs 6.5; allP< 0.01).ConclusionMany patients with axSpA had impairments in physical performance tests. Importantly, this was frequently seen in tasks requiring coordination and muscle power of the lower extremity. Performance tests provide qualitatively different information than BASFI and BASMI assessments in patients with axSpA.
Examining the Characteristics of Colchicine-Induced Myelosuppression in Clinical Cases: A Systematic Review
Authors: Sim Bernice L. , Sim Beatrice Z. , Tunbridge Matthew , Liew David F.L. , Robinson Philip C. 
Published: September 2022

ObjectiveThe use of colchicine has been associated with varying degrees of myelosuppression. Despite expanded use in cardiovascular and inflammatory conditions, there remains clinician concern because of potential myelosuppressive side effects. A systematic review was conducted to explore the reported myelosuppressive events of colchicine.MethodsA systematic review was conducted using the MeSH terms ("colchicine") AND ("myelosuppression," "bone*," "marrow," "suppression," "aplasia," "leukopenia/leucopenia," "lymphopenia," "neutropenia") on September 1, 2020, and was updated on November 30, 2021. The search was conducted in PubMed, ScienceDirect, Scopus, Embase, and Cochrane Library. The search included references published from 1978 to 2020 and was limited to English-language observational studies (ie, case reports, case series, case control studies, and cohort studies) or trial data.ResultsIn total, 3233 articles were screened, with 30 studies of 47 patients with myelosuppression from colchicine identified. Most patients with myelosuppression had comorbidities, including renal impairment (21/47, 44.7%). Out of 47 patients, 15 (31.9%) and 13 (27.7%) were reported to be concurrently taking cytochrome P450 3A4 (CYP3A4) inhibitors and P-glycoprotein (P-gp) efflux transporter inhibitors, respectively. Patients with renal impairment accounted for the majority of overall patients taking these CYP3A4 and P-gp inhibitors (8/15, 53.3%, and 8/13, 61.5%, respectively). Out of 21 patients with renal impairment, 13 had worsening cytopenia during colchicine use. The presentations ranged from moderate anemia (grade 2) to severe thrombocytopenia, neutropenia, and leukopenia (grade 4).ConclusionColchicine has few reports of myelosuppression. The majority of patients with myelosuppression had preexisting renal impairment or concomitant CYP3A4 or P-gp inhibitor use. Caution should be taken in this subset of patients with increased monitoring.
Le partenariat entre écoles et acteurs externes : un épisode éducatif interrompt le temps scolaire
Authors: Devos Lisa 
Published: September 2022

Face aux mutations rapides de la société dès la fin du XX e siècle, les écoles semblent compter de plus en plus sur les organisations de leur environnement pour remplir leurs missions qui se diversifient. Ainsi le partenariat scolaire a-t-il pris de l’ampleur au cours des dernières décennies, au point de devenir une norme pour les enseignants et les organisations non scolaires. Cet article resitue la croissance de ces collaborations dans le cadre des évolutions sociétales et du processus global d’expansion de l’éducation. Il analyse également, à partir d’une enquête qualitative menée auprès des acteurs scolaires et non scolaires actifs dans le champ des « éducations à », comment ces phénomènes sociétaux se concrétisent sur le terrain scolaire. À travers l’analyse des processus d’intégration des acteurs externes, nous proposons d’interpréter les partenariats comme un type particulier d’événements, appelés “épisodes”, venant interrompre le déroulement habituel des activités scolaires.
École inclusive, redéfinition du fait collectif et fonctions de l’accessibilité
Authors: Ebersold Serge 
Published: September 2022

L’ambition inclusive interroge la forme scolaire en supposant un changement de la culture scolaire : modification des formes de codification de l’espace et aménagement physique de la classe, organisation du temps, des rythmes et des codes de la pédagogie frontale selon les profils des élèves. Ces interrogations sont consubstantielles d’une redéfinition du fait collectif qui a singularisé les rapports sociaux et battu en brèche leur configuration historique. Cette redéfinition repose sur un paradigme productif assujettissant le bien-être économique et social à l’autonomie cognitive des individus. Elle place la production d’usage au cœur du travail scolaire : l’innovation par l’usage est matérialisée par l’aptitude des acteurs de l’école à transformer en ressources les opportunités de leur environnement pour élaborer des réponses propres à des situations particulières et s’adapter à la diversité des profils scolaires. L’enseignant inclusif accompagne les élèves dans la maîtrise de leurs apprentissages grâce à une personnalisation des pratiques, des démarches collaboratives et un souci de développement professionnel. L’apprenant, maître de ses apprentissages, peut s’autoréguler et s’engager dans les processus à l’œuvre. La centralité de cette production d’usage fait de l’accessibilité des environnements scolaires la condition de la concrétisation de l’autonomie cognitive reconnue aux élèves. Cette singularisation cognitive des individus se double d’une singularisation politique où ils voient des opportunités pour être les auteurs de leur devenir. Cette redéfinition du fait collectif s’organise aussi autour d’une singularisation juridique qui consacre un droit d’accès à l’offre de service public, ici de services éducatifs. Cela suppose le développement contextuel de pouvoirs d’agir équivalents entre des sujets porteurs de droits grâce auxquels ils peuvent surmonter leurs différences individuelles de capacité et lutter contre les ruptures de droits parfois engendrées par des conditions d’apprentissage inadéquates.
Aude Thuries, L’apparition de la danse : construction et émergence du sens dans le mouvement. À partir de la philosophie de Susanne Langer
Authors: Thuries Aude 
Published: September 2022

Notre travail de recherche propose d’envisager et d’étudier la danse en tant qu’activité constructrice de sens. Cette notion complexe a été diversement thématisée et explorée au cours de l’histoire de la danse, mais n’a que rarement été questionnée frontalement.Nous nous appuyons, pour mener à bien cette entreprise, sur les travaux de Susanne Langer, philosophe américaine du XXe siècle dont les ouvrages explorent la question du symbolique. Elle a développé, au sujet de la danse, une pensée originale, et élaboré des concepts proposant de circonscrire au mieux les processus symboliques à l’œuvre dans les pratiques non discursives, et en particulier dans l’art.Plutôt que d’aborder la danse d’un point de vue ontologique, comme une catégorie en soi sous laquelle subsumer certains mouvements, nous choisissons de la considérer comme un événement dont la survenue peut être intermittente. Approcher la danse sous cet angle permet de rendre compte de son éventuelle apparition dans toute forme de mouvement : de la danse artistique à la danse festive, du mime au cinéma, du rite à la création numérique.Ce choix de ne pas réduire a priori le champ d’étude permet, a posteriori, de redessiner une frontière nette entre la danse et les autres formes de mouvement ou de pratiques corporelles. Notre travail tend, en effet, à réaffirmer la spécificité fondamentale de la danse quels que soient les environnements, moments et corps dans lesquels elle apparaît — une spécificité tenant à ses processus symboliques uniques et aux sens qu’elle peut ainsi construire ou faire émerger.
No Association of Early Postoperative Heart Rate With Outcomes After Coronary Artery Bypass Grafting
Authors: Morita Yoshihisa , Kumasawa Junji , Miyamoto Yoshihisa , Izawa Junichi , Krishnamoorthy Vijay , Raghunathan Karthik , Bartz Raquel R. , Thompson Annemarie , Ohnuma Tetsu 
Published: September 2022

BackgroundElevated perioperative heart rate potentially causes perioperative myocardial injury because of imbalance in oxygen supply and demand. However, large multicenter studies evaluating early postoperative heart rate and major adverse cardiac and cerebrovascular events (MACCEs) are lacking.ObjectiveTo assess the associations of 4 postoperative heart rate assessment methods with in-hospital MACCEs after elective coronary artery bypass grafting (CABG).MethodsUsing data from the eICU Collaborative Research Database in the United States from 2014 to 2015, the study evaluated postoperative heart rate measured during hospitalization within 24 hours after intensive care unit admission. Four heart rate assessment methods were evaluated: maximum heart rate, duration above heart rate 100/min, area above heart rate 100/min, and time-weighted average heart rate. The outcome was in-hospital MACCEs, defined as a composite of in-hospital death, myocardial infarction, angina, arrhythmia, heart failure, stroke, cardiac arrest, or repeat revascularization.ResultsAmong 2585 patients, the crude rate of in-hospital MACCEs was 6.2%. In multivariable logistic regression analysis, the adjusted odds ratios (95% CI) for in-hospital MAC-CEs assessed by maximum heart rate in each heart rate category (beats per minute: &gt;100-110, &gt;110-120, &gt;120-130, and &gt;130) were 1.43 (0.95-2.15), 0.98 (0.56-1.64), 1.47 (0.76-2.69), and 1.71 (0.80-3.35), respectively. Similarly, none of the other 3 methods were associated with MACCEs.ConclusionsMore research is needed to assess the usefulness of heart rate measurement in patients after CABG.
Prevention of Endotracheal Tube–Related Pressure Injury: A Systematic Review and Meta-analysis
Authors: Moser Chandler H. , Peeler Anna , Long Robert , Schoneboom Bruce , Budhathoki Chakra , Pelosi Paolo P. , Brenner Michael J. , Pandian Vinciya 
Published: September 2022

Background
Hospital-acquired pressure injuries, including those related to airway devices, are a significant source of morbidity in critically ill patients.

Objective
To determine the incidence of endotracheal tube–related pressure injuries in critically ill patients and to evaluate the effectiveness of interventions designed to prevent injury.

Methods
MEDLINE, Embase, CINAHL, and the Cochrane Library were searched for studies of pediatric or adult patients in intensive care units that evaluated interventions to reduce endotracheal tube–related pressure injury. Reviewers extracted data on study and patient characteristics, incidence of pressure injury, type and duration of intervention, and outcomes. Risk of bias assessment followed the Cochrane Collaboration’s criteria.

Results
Twelve studies (5 randomized clinical trials, 3 quasi-experimental, 4 observational) representing 9611 adult and 152 pediatric patients met eligibility criteria. The incidence of pressure injury was 4.2% for orotracheal tubes and 21.1% for nasotracheal tubes. Interventions included anchor devices, serial endotracheal tube assessment or repositioning, and barrier dressings for nasotracheal tubes. Meta-analysis revealed that endotracheal tube stabilization was the most effective individual intervention for preventing pressure injury. Nasal alar barrier dressings decreased the incidence of skin or mucosal injury in patients undergoing nasotracheal intubation, and data on effectiveness of serial assessment and repositioning were inconclusive.

Conclusions
Airway device–related pressure injuries are common in critically ill patients, and patients with nasotracheal tubes are particularly susceptible to iatrogenic harm. Fastening devices and barrier dressings decrease the incidence of injury. Evidence regarding interventions is limited by lack of standardized assessments.
Dehydroabietic acid chemosensitizes drug-resistant acute lymphoblastic leukemia cells by downregulating survivin expression
Authors: Shen Li-Li , Huang Wei-Hua , Zhao Hui-Jun , Yuan Xue-Wei 
Published: September 2022

Objective:
To explore the mechanism of drug resistance in acute lymphoblastic leukemia and the anti-tumor effect of combination therapy of dehydroabietic acid and vincristine against acute lymphoblastic leukemia cells.

Methods:
Acute lymphoblastic leukemia cells REH and CCRF- CEM were employed to detect the anti-tumor effect of vincristine and doxorubicin on proliferation and apoptosis using EdU assay, human active caspase-3 Quantikine ELISA kit, and flow cytometry. Vincristine-resistant REH cells (REH-R), survivin knockdown and overexpressing REH cells were established to verify the role of survivin in drug resistance. Additionally, in vitro and in vivo assays were performed to determine the effect of dehydroabietic acid on the cytotoxicity of vincristine.

Results:
Vincristine and doxorubicin markedly suppressed proliferation and induced apoptosis of REH and CCRF-CEM cells. Survivin expression was upregulated in REH-R cells compared with REH cells. Knockdown of survivin expression obviously restored the sensitivity of REH-R cells to vincristine. Akt phosphorylation was also increased in REH-R cells compared to REH cells. In addition, LY294002, a PI3k/Akt pathway blocker, inhibited survivin expression and enhanced cytotoxicity of vincristine to REH-R cells. Dehydroabietic acid effectively reduced survivin expression in REH-R cells, thereby enhancing the therapeutic effect of vincristine on drug-resistant cells. Survivin overexpression markedly reduced the effect of dehydroabietic acid on enhancing the anti-proliferation and inducing apoptosis effect of vincristine. Moreover, the combination of dehydroabietic acid with vincristine significantly extended the survival rate in a mouse xenograft model of acute lymphoblastic leukemia, compared with vincristine treatment alone.

Conclusions:
Dehydroabietic acid may be used as a potential candidate for the treatment of acute lymphoblastic leukemia in combination with vincristine.
A study to rationalize the health-care (clinical and medical) record forms in use at SGPGIMS hospital, in conformance with inter/national guidelines, so as to ensure structural and contextual uniformity while updating the same for prospective in-house consumption by the end users
Authors: Harsvardhan Rajesh , Jaiswal Arushi , Kapoor Prerna , Halder Rudrashish 
Published: September 2022

Background:
Effectual management of medical records (MR) is a prime component in health-care delivery organizations. A standardized medical form facilitates for obtaining comprehensive information along with appropriate documentation for swift and efficient retrieval of information pertaining to the quality of patient care. It seems astounding that hitherto, there have been no set standards/criteria to evaluate MR forms. With this backdrop, the study aimed to rationalize MR forms in use at SGPGIMS in conformance with the inter/national guidelines as a stride toward quality improvement.

Aim:
The aim of this study was to rationalize the health-care (clinical and medical) record forms in use at SGPGIMS hospital, in conformance with inter/national guidelines, to ensure structural and contextual uniformity while updating the same for prospective in-house consumption by the end user.

Objectives:
The objective of this study was to obtain the health-care (clinical and medical) record forms in use at SGPGIMS hospital. To compare the health-care (clinical and medical) record forms in use at SGPGIMS hospital with inter/national guidelines through the appropriate designed tool, i.e., (structured checklist). To recommend an evidence-based modification in health-care (clinical and medical) record forms based on analysis of data obtained, to ensure structural and contextual uniformity while updating the same for the prospective in-house users, if required.

Methodology:
A descriptive study was carried out at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, with a study sample of preidentified health-care (clinical and medical) forms which are the core forms to all the departments of SGPGIMS, hospital. A customized validated tool kit (structured checklist) was designed in conformance with inter/national guidelines to assess the preidentified health-care (clinical and medical) forms.

Results:
The Medical Certificate of Cause of Death Form was found to have the highest compliance rate of 90.5% with the given set of parameters among the preidentified forms, while the Medication Chart and Assessment Form have noncompliance rates of 61.1% and 58.1%, respectively, with the given set of parameters. Rest other preidentified medical forms have the noncompliance rate of <50% with the given set of parameters of customized tool kit.

Conclusion:
Since this was the foremost study conducted, it was observed that there was a need to rationalize the MR forms by implementing the observations made, so as to ensure structural and contextual uniformity by the end users.
Effect of diode laser as an adjunct to open flap debridement in treatment of periodontitis – A randomized clinical trial
Authors: Kolamala Nikhitha , Nagarakanti Sreenivas , Chava Vijay Kumar 
Published: September 2022

Background:
The goals of periodontal therapy are to prevent the disease, arrest the disease progression, and regeneration of lost periodontium. Diode laser gained popularity in periodontal practice with a wide range of potential benefits.

Aim:
This study aims to evaluate and compare the clinical effects of laser-assisted open flap debridement (OFD) versus conventional OFD for the periodontitis treatment.

Materials and Methods:
A split-mouth, randomized clinical trial was conducted on fifteen participants with periodontitis having probing pocket depths (PPD) ≥5 mm. A total of 30 sites, two sites in each patient, were randomly divided into two groups. Group A received conventional OFD, and Group B received laser-assisted OFD. The assessment of PPD, relative attachment level (RAL), modified sulcular bleeding index (mSBI) was done at baseline, 3 months, and 6 months. Wound healing index (WHI) was assessed at 3rd and 7th day postsurgery, patient response to pain using visual analog scale (VAS) was assessed immediately, 1 day, and 1 week after surgery.

Results:
The results revealed a significant reduction in PPD, mSBI, and gain in RAL within the groups from baseline to 3 months and 6 months. Intergroup comparison showed a significant difference in PPD, RAL, mSBI, WHI and VAS scores.

Conclusions:
The use of 980 nm diode laser provided additional benefits over conventional flap therapy.
Proportions in papilla, crestal papilla, and proximal contact area in maxillary anterior teeth
Authors: Kolte Abhay Pandurang , Kolte Rajashri Abhay , Purohit Mukesh J. , Bajaj Vinisha A. 
Published: September 2022

Background:
The regeneration and maintenance of the interdental papilla presents a great challenge to the clinician while smile designing. Proportions of papilla height (PH), crestal PH (CPH), and proximal contact areas (PCA) are more stable parameters.

Aim:
The purpose of the present study was to evaluate and correlate the papilla proportion (PP), crestal PP (CPP), and PCA proportion (PCAP) in periodontally healthy males and females.

Materials and Methods:
One hundred and twenty patients in an age group of 20–40 years, divided equally based on gender, were assessed for PH, CPH, and PCA of maxillary anterior teeth. The findings were recorded on study models and radiographs to obtain the PP, CPP, and PCAP on the mesial and distal aspects of respective tooth.

Statistical Analysis:
The overall comparison of parameters was performed using paired t-test.

Results:
The mean mesial PP (43.51% ± 3.10% for male and 45.23% ± 2.23% for female) and CPP values (48.36% ± 3.35% for male and 51.16% ± 2.96% for female) were found to be greater of each tooth type and were more pronounced for females. The PCAP values were greater for distal aspects (36.76% ± 7.00% for males and 33.30% ± 6.93% for females).

Conclusion:
The results of the study indicate that PP and CPP are more pronounced in females, while the PCAP is more marked in males. Furthermore, it appears that the PP and CPP are inversely related to the PCAP in both males and females.
Comparative evaluation of the efficacy of amniotic membrane with collagen membrane along with demineralized freeze-dried bone allograft in the treatment of periodontal intrabony defects – A clinico-radiographic study
Authors: Agrawal Eiti , Chopra Rahul , Gupta Swyeta Jain , Sharma Nikhil , Khan Farheen , Gupta Neetika 
Published: September 2022

Context:
The use of human-derived amniotic barrier membranes in regenerative procedures along with allograft like demineralized freeze-dried bone allograft (DFDBA) has displayed promising outcomes.

Aims:
The objective of the current research was to clinically and radiographically evaluate and compare amniotic membrane (AM) and collagen membrane (CM) in combination with open flap debridement (OFD) along with DFDBA in the management of human periodontal intrabony defects.

Settings and Design:
The present research-based study was a randomized controlled clinical trial of 6 months duration.

Materials and Methods:
A total of twenty chronic periodontitis patients with intrabony defects were randomly divided into two groups: Group 1 treated with OFD + DFDBA + AM and Group 2 with OFD + DFDBA + CM. Clinical parameters such as plaque index (PI), gingival index (GI), pocket probing depth (PPD), and relative attachment level were recorded and evaluated at baseline, 3 months, and 6 months. The relative intrabony defect component level (rIBD) was recorded at baseline and after 6 months employing a millimeter X-ray grid.

Statistical Analysis Used:
For comparison of clinical parameters and radiographic parameters at various intervals unpaired t-test, repeated measures ANOVA test, and paired t-test were used. The P value was taken statistically significant when less than 0.05 (P < 0.05).

Results:
A statistically significant difference in PI, GI, PPD, and RAL for both the groups were found on intragroup comparison between baseline, 3 months, and 6 months (P < 0.05). On intragroup comparison, the difference in mean rIBD was statistically significant from baseline to 6 months. However, for all the clinical and radiographic parameters, no statistically significant difference was noted between both the groups (P > 0.05).

Conclusions:
In the treatment of intrabony defects AM being an allograft can be considered an alternative novel membrane for regenerative procedures.