Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses
Authors: Kalman Janos L. , Yoshida Tomoya , Andlauer Till F. M. , Schulte Eva C. , Adorjan Kristina , Alda Martin , Ardau Raffaela , Aubry Jean-Michel , Brosch Katharina , Budde Monika , Chillotti Caterina , Czerski Piotr M. , DePaulo Raymond J. , Forstner Andreas , Goes Fernando S. , Grigoroiu-Serbanescu Maria , Grof Paul , Grotegerd Dominik , Hahn Tim , Heilbronner Maria , Hasler Roland , Heilbronner Urs , Heilmann-Heimbach Stefanie , Kapelski Pawel , Kato Tadafumi , Kohshour Mojtaba Oraki , Meinert Susanne , Meller Tina , Nenadić Igor , Nöthen Markus M. , Novak Tomas , Opel Nils , Pawlak Joanna , Pfarr Julia-Katharina , Potash James B. , Reich-Erkelenz Daniela , Repple Jonathan , Richard-Lepouriel Hélène , Rietschel Marcella , Ringwald Kai G. , Rouleau Guy , Schaupp Sabrina , Senner Fanny , Severino Giovanni , Squassina Alessio , Stein Frederike , Stopkova Pavla , Streit Fabian , Thiel Katharina , Thomas-Odenthal Florian , Turecki Gustavo , Twarowska-Hauser Joanna , Winter Alexandra , Zandi Peter P. , Kelsoe John R. ,   Consortium on Lithium Genetics (ConLiGen), PsyCourse, Baune Bernhard T. , Fullerton Jan , Mitchell Philip B. , Schofield Peter R. , Wray Naomi R. , Wright Adam , Bengesser Susanne A. , Reininghaus Eva , Banzato Claudio E. M. , Dantas Clarissa , Alda Martin , Cruceanu Cristiana , Garnham Julie , Grof Paul , MacQueen Glenda , Rouleau Guy , Slaney Claire , Turecki Gustavo , Young L. Trevor , Jaramillo Carlos A. López , Novák Tomás , Stopkova Pavla , Brichant-Petitjean Clara , Adli Mazda , Gard Sébastien , Etain Bruno , Jamain Stéphane , Kahn Jean-Pierre , Leboyer Marion , Adli Mazda , Bauer Michael , Cichon Sven , Degenhardt Franziska , Falkai Peter , Gruber Oliver , Heilbronner Urs , Hoffmann Per , Kittel-Schneider Sarah , Nöthen Markus , Pfennig Andrea , Reich-Erkelenz Daniela , Reif Andreas , Rietschel Marcella , Schulze Thomas G. , Seemüller Florian , Stamm Thomas , Ardau Raffaella , Chillotti Caterina , Del Zompo Maria , Maj Mario , Manchia Mirko , Monteleone Palmiero , Severino Giovanni , Squassina Alessio , Tortorella Alfonso , Akiyama Kazufumi , Akiyama Kazufumi , Hashimoto Ryota , Kato Tadafumi , Kusumi Ichiro , Masui Takuya Masui Takuya , Ozaki Norio , Czerski Piotr , Hauser Joanna , Kliwicki Sebastian , Rybakowski Janusz K. , Grigoroiu-Serbanescu Maria , Obregia Alexandru , Arias Bárbara , Benabarre Antonio , Colom Francesc , Jiménez Esther , Mitjans Marina , Vieta Eduard , Backlund Lena , Backlund Lena , Frisén Louise , Lavebratt Catharina , Martinsson Lina , Ösby Urban , Schalling Martin , Aubry Jean-Michel , Cichon Sven , Dayer Alexandre , Hoffmann Per , Nallet Audrey , Chen Hsi-Chung , Cousins David , Akula Nirmala , Biernacka Joanna M. , Biernacka Joanna M. , Bui Elise T. , DePaulo J. Ray , Detera-Wadleigh Sevilla D. , Frye Mark A. , Goes Fernando S. , Hoban Rebecca , Hou Liping , Kassem Layla , Kelsoe John R. , Kelsoe John R. , Laje Gonzalo , Laje Gonzalo , Leckband Susan G. , McCarthy Michael J. , McMahon Francis J. , Perlis Roy H. , Potash James B. , Schulze Thomas G. , Schweizer Barbara , Seymour Lisa R. , Smoller Jordan W. , Steele Jo , Tighe Sarah , Zandi Peter P. , Reininghaus Eva , Banzato Claudio E. M. , Dantas Clarissa , Alda Martin , Cruceanu Cristiana , Garnham Julie , Grof Paul , MacQueen Glenda , Rouleau Guy , Slaney Claire , Turecki Gustavo , Young L. Trevor , Jaramillo Carlos A. López , Novák Tomás , Stopkova Pavla , Brichant-Petitjean Clara , Etain Bruno , Adli Mazda , Gard Sébastien , Jamain Stéphane , Kahn Jean-Pierre , Leboyer Marion , Adli Mazda , Bauer Michael , Cichon Sven , Degenhardt Franziska , Falkai Peter , Gruber Oliver , Heilbronner Urs , Hoffmann Per , Kittel-Schneider Sarah , Nöthen Markus , Pfennig Andrea , Reich-Erkelenz Daniela , Reif Andreas , Rietschel Marcella , Schulze Thomas G. , Seemüller Florian , Stamm Thomas , Ardau Raffaella , Chillotti Caterina , Del Zompo Maria , Del Zompo Maria , Maj Mario , Manchia Mirko , Monteleone Palmiero , Severino Giovanni , Squassina Alessio , Tortorella Alfonso , Akiyama Kazufumi , Hashimoto Ryota , Kusumi Ichiro , Masui Takuya , Ozaki Norio , Czerski Piotr , Hauser Joanna , Kliwicki Sebastian , Rybakowski Janusz K. , Grigoroiu-Serbanescu Maria , Obregia Alexandru , Arias Bárbara , Benabarre Antonio , Colom Francesc , Jiménez Esther , Mitjans Marina , Vieta Eduard , Backlund Lena , Frisén Louise , Lavebratt Catharina , Martinsson Lina , Ösby Urban , Schalling Martin , Aubry Jean-Michel , Cichon Sven , Dayer Alexandre , Hoffmann Per , Nallet Audrey , Chen Hsi-Chung , Cousins David , Akula Nirmala , Biernacka Joanna M. , Bui Elise T. , DePaulo J. Ray , Detera-Wadleigh Sevilla D. , Frye Mark A. , Goes Fernando S. , Hoban Rebecca , Hou Liping , Kassem Layla , Kelsoe John R. , Laje Gonzalo , Leckband Susan G. , McCarthy Michael J. , McMahon Francis J. , Perlis Roy H. , Potash James B. , Schulze Thomas G. , Schweizer Barbara , Seymour Lisa R. , Smoller Jordan W. , Steele Jo , Tighe Sarah , Zandi Peter P. , Falkai Peter , Dannlowski Udo , Kircher Tilo , Schulze Thomas G. , Papiol Sergi 
Published: February 2022

AbstractPersonality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.