bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Exogenous Glycine Betaine and Cycloleucine on Photosynthetic Capacity, Amino Acid Composition, and Hormone Metabolism in Solanum melongena L
Authors: Niu Tianhang , Zhang Jing , Li Jing , Gao Xiaoping , Ma Hongyan , Gao Yanqiang , Chang Youlin , Xie Jianming 
Published: December 2022

Abstract
Although exogenous glycine betaine and cycloleucine have been reported to affect animal cell metabolism, their effects on plant growth and development have not been studied extensively. Different concentrations of exogenous glycine betaine (20, 40, and 60 mmol L− 1) and cycloleucine (10, 20, and 40 mmol L− 1), with 0 mmol L− 1 as control, were used to investigate the effects of foliar spraying of betaine and cycloleucine on growth, photosynthesis, chlorophyll fluorescence, Calvin cycle pathway, abaxial leaf burr morphology, endogenous hormones, and amino acid content in eggplant. We found that 40 mmol L− 1 glycine betaine had the best effect on plant growth and development; it increased the fresh and dry weight of plants, increased the density of abaxial leaf hairs, increased the net photosynthetic rate and Calvin cycle key enzyme activity of leaves, had an elevating effect on chlorophyll fluorescence parameters, increased endogenous IAA content and decreased ABA content, and increased glutamate, serine, aspartate, and phenylalanine contents. However, cycloleucine significantly inhibited plant growth; plant apical dominance disappeared, plant height and dry and fresh weights decreased significantly, the development of abaxial leaf hairs was hindered, the net photosynthetic rate and Calvin cycle key enzyme activities were inhibited, the endogenous hormones IAA and ABA content decreased, and the conversion and utilization of glutamate, arginine, threonine, and glycine were affected. Combined with the experimental results and plant growth phenotypes, 20 mmol L− 1 cycloleucine significantly inhibited plant growth. In conclusion, 40 mmol L− 1 glycine betaine and 20 mmol L− 1 cycloleucine had different regulatory effects on plant growth and development.
Duodenal metastasis of renal cell carcinoma: a case report
Authors: Yinhe Sikong , Yang Jiao , Kun Feng , Aijun Zhang 
Published: December 2022

Abstract
Background
Duodenal metastasis of renal cell carcinoma(RCC) is a very rare disease entity, and often occurs years after nephrectomy for RCC.
Case presentation:
Here we report a case of 53-year-old woman presenting with chronic anemia and malnutrition 4 years after right nephrectomy. On esophagogastroduodenoscopy(EGD), a giant semitransparent mass was located in the descending segment of duodenum, and the patient underwent Whipple’s operation with excellent recovery. The histopathology confirmed the diagnosis of duodenal metastasis of RCC.
Conclusion
In a patient with past history of nephrectomy for RCC, when encountered with unique endoscopic features, metastasis of RCC should be suspected and perform thorough evaluation, including surgery.
Looking for biomarkers in interferon response pathway to predict response to oncolytic HSV-1 in breast cancer: An ex vivo study
Authors: Nejatipour Zahra , Toulabi Ladan Teimouri , Forooshani Ramin Sarrami , Barough Mahdieh Shokrollahi , Farahmand Mohammad , Biglari Alireza , Azadmanesh Kayhan 
Published: December 2022

Abstract
Breast cancer is the most common malignancy in women worldwide. Administration of oncolytic viruses is one of the novel promising cancer therapy approaches. Replication of these viruses is usually limited to cancer cells that have interferon (IFN) signaling defects. However, Interferon signaling is not completely impaired in all cancer cells which may limit the benefits of virotherapy. Identification of realistic IFN-mediated biomarkers to identify patients who most likely respond to virotherapy would be helpful. In this study, eight patients-derived primary tumor cultures were infected with an ICP34.5 deleted oHSV, then the rate of infectivity, cell survival, and expression of the gene involved in IFN pathway were analyzed. Data showed that mRNA expressions of Myeloid differentiation primary response protein (Myd88) is significantly higher in tumors whose primary cultures showed less cell death and resistance to oHSV infectivity (P-value < 0.05). The differentiating cut off of Myd88 expression, inferred from the receiver operating characteristic (ROC) curve, predicted that only 13 out of 16 other patients could be sensitive to this oHSV. Identifying such biomarker improves our ability to select the patients who do not exhibit resistance to virotherapy.
Pilot study examining the feasibility and safety of an exercise during chemotherapy in patients with gastrointestinal cancers
Authors: Park Song Ee , Kim Du Hwan , Kim Don-Kyu , Ha Joo Young , Jang Joung-Soon , Choi Jin Hwa , Hwang In Gyu 
Published: December 2022

Abstract
Purpose
Sarcopenia is a poor prognostic factor in cancer patients, and exercise is one of the treatments to improve sarcopenia. However, there is currently insufficient evidence on whether exercise can improve sarcopenia in patients with advanced cancers. This study examined the feasibility of exercise in advanced gastrointestinal (GI) cancer patients treated with palliative chemotherapy.
Methods
Between 2020 and 2021, 30 patients were enrolled in a resistance and aerobic exercise program for six weeks. The exercise intervention program (EIP) consisted of low, moderate, and high intensity levels. Patients were asked to select the intensity level according to their ability. The primary endpoint was the feasibility of the EIP measured by compliance during the six weeks. A compliance of over 50% was considered acceptable. The secondary endpoints were changes in weight and muscle mass, safety, quality of life (QoL) and overall survival (OS).
Results
The median age of the study’s participants was 60 (30–77). The total compliance to the EIP was 63.3% (19/30 patients). Sixteen (53.3%) patients had a compliance of over 80%. The attrition rate was 30.0% (9/30). The mean exercise time was 41.4 minutes, and the aerobic exercise was 92.3% and the resistant exercise was 73.7%, and both exercise was 66.5%. Most patients performed the moderate intensity level exercises at home or near their home. The mean skeletal muscle index (SMI) was 43.5 cm2/m2 pre-chemotherapy and 42.2 cm2/m2 after six weeks of chemotherapy, with a decrease of -1.2 ± 2.8 cm2/m2 (-3.0%) (p = 0.030). In the poor compliance group, the mean SMI decrease was − 2.8 ± 3.0 cm2/m2 which was significantly different (p = 0.033); however, in the good compliance group, the mean SMI decrease was − 0.5 ± 2.5 cm2/m2 which was maintained over the six weeks (p = 0.337). The insomnia was showed a better score (p = 0.042) and there were no serious adverse events.
Conclusions
The EIP during palliative chemotherapy in advanced GI cancer patients showed good compliance. In the good compliance group, muscle mass and physical functions were maintained for six weeks. The EIP was safe, and the QoL was maintained. Based on this study, further research in exercise intervention in advanced cancer patients is needed.
Novel Application of Real-Time Editable 3D-reconstructed Imaging in a Mixed-Reality Holographic Overlay Using a Video Pass-through Head-Mounted Display – A Pathway to future Navigation in Thoracic Surgery?
Authors: Arensmeyer Jan , Bedetti Benedetta , Schnorr Philipp , Buermann Jens , Zalepugas Donatas , Schmidt Joachim , Feodorovici Philipp 
Published: December 2022

Abstract
Introduction: 3D reconstructions of widely available high-resolution imaging is only rarely used for
preprocedural assessment in thoracic surgery. However, it is a promising tool that aims to improve
patient-specific treatment planning. Increasingly available mixed reality hardware based on video
pass-through technology enables to project image data as a hologram onto the patient. We describe
the novel method of real-time 3D surgical planning in a mixed reality setting presenting two
representative cases.
Material and Methods: A mixed reality system was set-up using a highperformance
workstation running a video pass-through based head-mounted display. Image data of
computer tomography was imported and visually customized through live editing. The image-based
hologram was projected onto the patient highlighting the regions of interest.
Results: Two oncological
cases were selected, both presenting large tumor masses in the thoracic cavity. We aligned 3D
holographic image data onto the patient allowing us to investigate the relationship between
anatomical structures and their respective body position.
Discussion and Outlook: The exploration of
holographic overlay proved to be promising in improving preprocedural surgical planning, particularly
on complex oncological tasks in the thoracic surgery area. A pilot study on approach planning shall
therefore be conducted. Ongoing technological progresses of extended reality hardware and
intelligent software features will most likely enhance applicability and range of use in surgical fields
within the near future.
The Schrödinger representation of Heisenberg group in terms of linear canonical transform
Authors: Kumar Amit , Prasad Akhilesh 
Published: December 2022

Abstract
In this paper, we deduce the Heisenberg group by using the translation and modulation operators of the linear canonical transform(LCT) in place of the Fourier transform and corresponding Schr\"{o}dinger representation is given. Apart from this the linear canonical Wigner transform is defined. Moreover, various analytic expressions, such as Schr\"{o}dinger representation is a unitary operator on $ L^{2}(\mathbb{R}^{n}) $ are discussed.
Food and feeding habits of four major commercial fish species on the central west coast of India
Authors: khandeparkar Akshadha S. , Gauns Manguesh , Sawant Nitin S. 
Published: December 2022

Abstract
In the present study, four species of commercial fish species namely Rastrelligar kanarguta, Tenualosa ilisha, Mugil cephalus and Sardinella longiceps were studied to understand their planktonic gut composition. This investigation was carried out by collecting locally caught fresh fish specimens from Coco beach at Nerul, Bardez-Goa, India from October 2019 to March 2020. These specimens were caught using the fishing gears such as cast net/gill net/seine nets operated from motorized canoes/crafts in the near shoreline region. Fishes mentioned in this report feed mainly on zooplankton i.e., copepods and bivalves. The copepod that dominated the gut content most of which were in semi-digested form apart from diatom and bivalve larvae. However, during the winter period, February and March, gut content was full of non-motile, marine dinoflagellates (ca. 200–500µm in size) represented by Pyrocystic sp. The study concludes that these commercial fishes show seasonal variation in feeding patterns and food selection (zooplankton ← → phytoplankton)
Characteristics of the tropical tropopause over the northeast monsoon region
Authors: Pooja Purushotham , Mehta Sanjay Kumar , Kakkanattu Sachin Philip , Betsy K. B. , Seetha C. J. , Musaid P. P. 
Published: December 2022

Abstract
In this study, we have characterized the tropical tropopause parameters such as the cold point tropopause (CPT) height (CPT-H) and temperature (CPT-T), convective tropopause (COT) height (COT-H) and temperature (COT-T), and the tropical tropopause layer (TTL) using radiosonde observations during 2014–2019 over Chennai (13.0oN, 80.06oE) located in the northeast (NE) monsoon region. The water vapor and ozone data from the microwave limb sounder (MLS) simultaneous to the radiosonde observations are also utilized to understand their roles on the CPT variations for different convective conditions obtained from Infrared brightness temperature (IRBT) data. CPT over Chennai becomes higher (17.6 ± 0.3 km) and colder (189.7 ± 0.9 K) during the winter season and lower (16.6 ± 0.2 km) and warmer (192.1 ± 1.0 K) during the summer monsoon season, however, not in the same month. The water vapor (CPT-W) and ozone (CPT-O) mixing ratios at CPT are found to be lower (~ 70 ± 1.4 ppmv and 3.1 ± 0.4 ppmv) during the winter season and higher (153 ± 4.2 ppbv and 4.8 ± 0.6 ppmv) during summer monsoon season. COT, however, becomes lower (12.4 ± 0.3 km) and higher (13.3 ± 0.3 km) during premonsoon and summer monsoon seasons, respectively. The TTL thickness is lesser (3.5 ± 0.6 km) and greater (4.8 ± 0.8 km) during winter and summer monsoon seasons. Over Chennai, the seasonal variation of the upper troposphere and lower stratospheric temperature, water vapor, and ozone anomalies are found to be in phase. We have categorized tropical convections as non-penetrative and penetrative. It is observed that the TTL temperature warms with the increasing strength of the non-penetrative convections and cools for the penetrative convection.
NRF2 suppression increases the susceptibility of hepatocellular carcinoma cancer cells to paclitaxel
Authors: Maghsoudi Mohaddeseh , Khalaj-Kondori Mohammad , Safaei Sahar , Amini Mohammad , Doustvandi Mohammad Amin , Hasani Shima , Riazi Negin , Baradaran Behzad 
Published: December 2022

Abstract
Background
Hepatocellular carcinoma (HCC) is one of the principal causes of cancer related death globally, and is one of the most common primary liver malignancies. The nuclear factor erythroid 2–related factor 2 (NRF2), regulates a wide range of detoxifying and antioxidant protection gene expression in the liver. Increased NRF2 expression is positively associated with the progression of a variety of cancers, including hepatocellular carcinoma. Our study aimed to consider the combination effect of NRF2-specific siRNA and paclitaxel (PTX) on apoptosis, autophagy induction, growth, and migration inhibition in HCC.
Methods
At first, using bioinformatics studies, HepG-2 cells were selected for the functional experiment. Then transfection of the cells was conducted with NRF2-siRNA and then treated with PTX. Cell viability was measured by the MTT assay, apoptosis was evaluated by the Annexin V/PI staining, autophagy was detected by the MDC staining, cell cycle arrest was determined by the flow cytometry, and cell migration was assessed by the wound healing assay. Finally, qRT-PCR was used to analyze the expression of migration and apoptosis genes (MMP-9, MMP-2, Bax, caspase-3, caspase-9, and Bcl-2).
Results
According to the results of our study, the expression of NRF2 was noticeably lessened by the NRF2-siRNA. Also, the NRF2-siRNA transfection could increase PTX-induced apoptosis. Besides, NRF2-siRNA and PTX were demonstrated to cooperatively suppress cell migration, increase arrest in sub-G1 and G2/M phase, and induce autophagy in HepG-2 cells. Additionally, we found that the use of NRF2-siRNA increased the sensitivity of HepG-2 cells to PTX via modulating the expression of apoptosis-related genes, including Bax, caspase-3, caspase-9, and Bcl-2 and migration-related genes including MMP-2 and MMP-9.
Conclusion
NRF2 knockdown in combination with PTX could be a promising treatment for hepatocellular carcinoma.
Runs of homozygosity and signatures of selection for number of oocytes and embryos in the Gir Indicine cattle
Authors: Rocha Renata de Fátima Bretanha , Garcia Arielly Oliveira , Otto Pamela Itajara , Silva Marcos Vinícius , Martins Marta Fonseca , Machado Marco Antônio , Panetto João Claudio , Guimarães Simone Eliza Facioni 
Published: December 2022

Abstract
Runs of homozygosity (ROH) and signatures of selection are results of selection processes in livestock species that has been shown to affect several traits in cattle. The aim of the current work was to verify the profile of ROH and inbreeding depression in the number of total (TO) and viable oocytes (VO), and number of embryos (EMBR) in Gir Indicine cattle. In addition, we aimed to identify signatures of selection, genes and enriched regions between Gir subpopulations sorted by breeding value for these traits. The genotype file contained 2,093 animals and 420,718 SNP markers. Breeding values used to sort Gir animals were previously obtained. ROH and signature of selection analyses were performed using PLINK software, followed by ROH- and pedigree-based inbreeding (FROH) and search for genes and their functions. A total of 105,327 ROHs were found in Gir cattle. ROHs were separated in classes according to the size, ranging from 1 to 2 Mb (ROH1–2 Mb: 58.17%), representing ancient inbreeding, ROH2–4 Mb (22.74%), ROH4 − 8 Mb (11.34%), ROH8 − 16 Mb (5.51%) and ROH> 16 Mb (2.24%). Putting together our results, we conclude that the increase in general ROH-based and pedigree-based inbreeding significantly decreases TO and VO; however, the way ROH affects the traits vary among chromosomes. In the analysis for signatures of selection, we identified 15 genes from 47 significant genomic regions, indicating differences in populations with high and low breeding value for the three traits.
Some Thermodynamics Aspects in Regular Gaussian Black Hole
Authors: malekolkalami Behrooz , Sharafi Maasoomeh 
Published: December 2022

Abstract
Asymptotically Anti–de Sitter (Black Hole) spacetimes are of theoretical and mathematical interest and attractive. Especially if these spaces are free of singularity, attraction to them may increase. An example of such spacetime is the Regular Gaussian Black Hole. In this manuscript, apart from examining some properties of these black holes, the comparison between the de Sitter and Anti–de Sitter types shows that the latter has a much better match with the laws of the real world and especially with the laws of thermodynamics.
Three-dimensional relationship between the degree of bilateral impacted mandibular third molars angulation and the mandibular dental arch parameters: a cross-sectional comparative study
Authors: Haider Ohood , Sharaf Mufeed A. , Abdulqader Abbas Ahmed , Alhashimi Najah , Sherrhan Hassan , Chen Chen , Alsoufi Waleed , Ting Zeng Yun , Wei Xiao Li , Alhammadi Maged S. 
Published: December 2022

Abstract
Objectives: The purpose of this study was to three-dimensionally evaluate the relationship between the degree of bilateral impacted mandibular third molars (IM3M) angulation and the mandibular dental arch parameters in normal skeletal and dental malocclusion patients.
Materials and Methods: In this retrospective cross-sectional comparative study, 120 adult subjects’ cone beam computed tomography (CBCT) images were three-dimensionally analyzed. The sample was divided into four groups according to degree of M3M buccolingual angulation (BL°); Group A <12° on the center of the ridge (N=30), Group B 12-24° off-center of the ridge (N=40), Group C >24° off center of the ridge (N=30), and Group D (control group with normal erupted bilateral M3M).The study subjects were further also divided into three groups according to IM3M mesiodistal angulation (MD°); Group 1 from10° to 45°, Group 2> 45° and Group 3 (control group with normal erupted bilateral M3M, 0 -10°). Comparison within and between groups were performed using One-way ANOVA followed by Tukey's post hoc test, respectively. Correlation between IM3M, BL and MD angulation and mandibular arch parameter was calculated using Pearson's correlation coefficient.
Results: Statistically significant differences (P < .001) were founded between the IM3M BL° and anterior teeth inclination, arch length (AL) and inter second molar width (inter 2nd MW) as well as between the IM3M MD° with anterior crowding and the arch length (P < .001). Significant positive correlation was founded between IM3M BL° and anterior teeth inclination, and between IM3M MD° and anterior teeth crowding and inter 2nd MW. Significant negative correlation was observed between IM3M BL° and inter 1st MW and 2nd MW.
Conclusion: The degree of buccolingual and mesiodistal angulation of the impacted mandibular third molars was associated with mandibular dentoalveolar changes. The increase in buccolingual angulation is associated with increase of anterior teeth inclination, and the decrease of 1st and 2nd inter-molars width. The increase in mesiodistal angulations was associated with increase in anterior teeth crowding and 2nd inter-molars width.
Clinical relevance: Assessment of the relationship between the impacted mandibular third molars and the degree of arch discrepancy, and the position of mandibular incisors in the three planes of space might help in the decision-making process for extraction of the impacted third molars in adult patients.
Exploration on effect of thermal cycling treatment on mechanical and tribological performance of polyimide composites
Authors: Wang Yanming , Wang Yizheng , Wu Zhicheng , Zhang Xiaoliang , Li Feibo , Wang Guangshuo , Li Zongqi , Mu Jingbo , Li Ping , Zhang Zhixiao , Wang Zehu , Gao Xiaohong 
Published: December 2022

Abstract
Polyimide (PI) and PI composites reinforced with glass fiber (GF), and aramid fiber (AF) were fabricated with hot-pressing technology. And then polyimide and its composites were treated with thermal cycling (TC) condition from -50 ℃ to 150 ℃ with 300 cycles continuously. Compared with the samples without suffering from TC treatment, the fracture morphology, mechanics and tribological properties of the samples were studied. The results showed that, based on the fractographic morphologies, the phenomenon of fiber stripping could be obviously observed in the PI composite materials after TC treatment. And the bending modulus slightly decreased compared with the almost unchanged bending strength before and after TC treatment. Compared with before TC treatment, the friction coefficients (FC) and wear rates (WR) of PI and PI composites showed different variations respectively. In conclusion, TC treatment had a great influence on the morphologies of the worn surface and the composition of transfer film. As the shear force increases, the elemental analysis demonstrated that GF was extruded into the groove.
Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and naïve patients
Authors: Kotani Satoshi , Shibagaki Kotaro , Hirahara Noriyuki , Tanabe Ryo , Ebisudani Yuri , Nonomura Saya , Kishimoto Kenichi , Takahashi Yusuke , Kataoka Masatoshi , Oka Akihiko , Fukuba Nobuhiko , Mishima Yoshiyuki , Oshima Naoki , Kawashima Kousaku , Ishimura Norihisa , Araki Asuka , Kadota Kyuichi , Ishihara Shunji 
Published: December 2022

Abstract
Purpose
The incidence of gastric neoplasms in Helicobacter pylori (Hp)-naïve patients has recently increased due to a remarkable decrease in the Hp–infected population in Japan. We investigated the clinicopathologic differences between patients with Hp-infected gastric neoplasms (HpIGNs) and those with Hp-naïve gastric neoplasms (HpNGNs) that have not been fully elucidated so far.
Methods
This retrospective study investigated 887 patients with 1010 gastric dysplasia or cancers who underwent endoscopic or surgical treatment for the recent decade. Clinical and neoplastic features were compared between HpIGN and HpNGN cases.
Results
HpNGNs accounted for 4.5% (45/1010) of all gastric neoplasm cases, but were found concentratedly in the latter five-years. Nine hundred sixty-five HpIGNs included 774 differentiated-type and 191 undifferentiated-type. Forty-five HpNGNs included 4 undifferentiated type, 5 fundic-gland type, 32 foveolar type, 3 intestinal type, and 1 other differentiated type. HpNGNs occurred in significantly younger patients (59.9 vs. 71.8 years, p<0.05), were found more frequently in the proximal compartment (p<0.05), and had smaller size (median 3.0 vs. 20.0 mm, p<0.05). Histologically, HpNGNs also showed a lower prevalence of invasive cancer (13.3% vs. 41.7%, p<0.05) and lymphovascular invasion (2.2% vs. 34.9%, p<0.05) as compared with HpIGN cases. Nearly all HpNGNs (44/45, 97.8%) were diagnosed in the early pathological stage, while 17.8% (172/965) of HpIGNs were diagnosed in an advanced stage (p=0.058).
Conclusions
HpNGN occurrence has recently been increasing along with an increase in Hp-naïve population and in knowledge about this type of tumor, though with a lower grade of biological malignancy regardless of histologic type.