bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chlorpheniramine, an Old Drug with New Potential Clinical Applications:
A Comprehensive Review of the Literature
Authors: Rizvi Syed A.A. , Ferrer Gustavo , Khawaja Uzzam A. , Sanchez-Gonzalez Marcos A. 
Published: June 2022

Abstract:
Chlorpheniramine Maleate (CPM), also known as chlorphenamine, is a potent alkylamine
first-generation H1 antihistamine that has been used since the 1950s. CPM is a widely popular drug
commonly used to treat allergic conditions, given its antihistamine properties. Although mainly used
in over-the-counter treatment for cough and colds, various studies discuss a wide range of CPM's clinical
uses, such as treating asthma, plasma cell gingivitis, chronic urticaria, and depression, among others.
This antihistamine is usually taken orally; however, intravenous, intramuscular, and subcutaneous
routes have been documented. Intranasal routes of this drug have recently been explored, especially
due to its antiviral properties against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Accordingly, given CPM's extensive medical and safety profile, the present review explores this versatile
drug's current and potential clinical applications. Although it is widely used mainly for treating
common colds and aforementioned allergic conditions, CPM can be used for other clinical indications.
The repurposing of CPM for other clinical indications, such as COVID-19, needs to be further explored
through more extensive studies.
The Russian Labor Market in the Information Technology Industry in 2021
Authors: Tomakova R. A. , Tomakov V. I. 
Published: June 2022

Relevance. The pandemic served as a catalyst for the digitalization of the economy, accelerated the processes of automation and digitalization in all spheres of the economy and in the social life of society. The key problem faced by IT companies in connection with the widespread introduction of information technology is the increased need for qualified programmers and analysts. The current situation has led to the need to assess the labor market of the IT sector in order to identify trends in meeting the demand for IT specialists.The purpose of the study: to assess the current situation and trends in the development of the labor market of IT specialists in our country after a one-year pandemic.The objectives: the number of IT specialists in the country's economy; the job market, requests and offers from employers; the structure of vacancies; activity and portrait of applicants.The research methodology is based on a systematic approach. The research is based on a resource approach. Traditional methods for theoretical and applied research were used - statistical analysis, synthesis, comparison, generalization. The research material was statistical data of Rosstat and the All-Russian federal database of vacancies and resumes, analytical materials of labor market research of IT specialists.Results. The pandemic accelerated the processes of digitalization of the economy and social life of society, caused a new round of competition for IT specialists. Research has revealed a growing need for IT specialists in all areas of the economy. There was an imbalance of supply and demand in the industrial labor market. Programmers are one of the most needed and paid specialists, the need for which is observed in all sectors of the economy.Conclusions. There was a need to change the paradigm of staff search and recruitment. How well the employer company will be represented on the market and how well it will behave with applicants in the process of coordinating the interests of the employer and the employee, so the success of hiring the right specialist will be ensured.
Academic Procrastination Among Students: a Sociological Analysis
Authors: Vetrova O. A. , Oboznaya M. V. 
Published: June 2022

Relevance. The student's age plays a key role in the process of educational and professional socialization of the individual, during which the stage of growing up, developing a sense of identity and planning their future takes place. One of these stages is the process of educational activity, which plays an important role in strengthening faith in one's own success, the ability to be productive. However, there are also obstacles that limit the complex formation of personality ‒ procrastination in postponing academic affairs or academic procrastination.The purpose is to determine the nature of the formation of academic procrastination of students, as well as to identify the importance of motivation in the structure of these factors.Objectives: to conduct an empirical study and analyze the reasons for the formation of academic procrastination of students; to study the educational motives of students, to determine the fundamental difference between the performance of long-term and daily educational tasks, cases of willing fulfillment of these tasks, as well as the emotional prerequisites of students who have decided not to perform educational tasks, regardless of their urgency and time costs.Methodology. The study used a methodology aimed at identifying the motives of educational activity among students, the methodology "PASS procrastination assessment Scale" in the adaptation of M. V. Zvereva, and factor analysis by the method of principal components, as well as a survey of student youth by means of a questionnaire.Results. Interpretation of the data obtained allowed us to confirm the existence of the problem of academic procrastination and its impact on academic motivation among students. Professional and educational-cognitive motives are among the driving motives that guide students to academic activity. The most common form of academic procrastination is procrastination in completing long-term tasks.Conclusions. Further sociological research should take into account a whole set of theoretical and methodological grounds on the basis of which it is possible to present the phenomenon of academic procrastination in its entirety and totality.
The Crisis of the Sovereign State-Nation and the "Rational Discussion": the Liberal Discourse of the "Salvation" of Democracy and the "Common Good"
Authors: Maltsev K. G. , Maltseva A. V. 
Published: June 2022

Relevance. The crisis of the modern European sovereign nation-state is defined as existential (not "technical"); therefore, we should talk about a socio-philosophical study of the "crisis of the foundations".The purpose of the article is to present the non-reality of the foundations of the nation-state in modern times, totally determined by the dominant liberal economic paradigm of the political (J. Agamben), and modern ways of removing the consequences of the political crisis in the liberal tradition.The objective is based on the interpretation of these statements - to determine the conditions and boundaries of the possibility of "response" from the perspective of "liberal metaphysics".Methodology. According to K. Schmitt, liberalism is "consistent metaphysics", the essence of which is defined as "endless free / public discussion"; a consistent liberal "response" to the challenge, therefore, can only be given on the basis of the named "essence" ‒ the main methodological position that determines the structure and content of this article.Results. It was revealed, that a nation as a form of political unity of a sovereign people, in the perspective of liberal metaphysics, cannot be relied on as a "substance of the state". That the people-sovereign is "split in itself" and the available ways of actualizing its real unity are no longer "valid". That the mechanisms of political representation that democratically legitimize the power institutions of a sovereign nation-state in its new European, that is, liberal, form, need radical reform. "Free discussion", stated in the article, is limited in the possibility of "answering" the "existential crisis"; this presupposes the need to reduce the "political" (Schmitt's "concept of the political" as an "existential solution" of the sovereign in the horizon of the existential opposition "friend – enemy") and "reduction" by means of such a reduction of the "essentially political" to technical issues of "governance" (M. Weber). Three main methods of "liberal reduction of the political" are distinguished: "logical-epistemological" by Y. Elster, "ethical" by J. Rawls, "aesthetic" by R. Ankersmit, and their characteristic "features" are determined.Conclusion. It is concluded that a consistent liberal political philosophy, losing in its understanding of politics as government, the distinction between auctoritas and potestas, is unable to thematize the "existential", that is, political, crisis of the foundations of a sovereign nation-state.
Ecological Technosphere as the Basic Context of the Formation of the Sociotechnical Landscape
Authors: Belkina V. A. 
Published: June 2022

Relevance. The rapid development of the technosphere has played a huge role in the qualitative change of numerous processes in all spheres of human social life. The evolution of the modern anthropo-techno sphere, including the formation of the latest technologies, has led to the emergence of the sociotechnical landscape (STL). STL, being a system of representation of various phenomena of the ecological technosphere, at the same time causes various problems and provides significant opportunities for humanity. All this makes it necessary to determine the prospects for the greening of the technosphere, as well as the main trends in the influence of STL models on modern society, man and the environment. The purpose is conducting a philosophical analysis of the ecological technosphere as the basic context of the formation of the sociotechnical landscape (STL).Objectives: to define the essence of the concept of "ecological technosphere" in its relationship with the new socio-cultural model of the lifestyle of human civilization; consider the TABLE construct as an explication of the ecological technosphere and the anthropoecological system as a whole; to trace the formation of STL through the prism of industrial revolutions; describe Industry 4.0 as a result of the integration and combination of the effects of multiple technologies; to identify the main prospects for further interaction between the technosphere and the ecosphere.Methodology. To substantiate the concept of anthropological complementarity, assuming the fact that human activity includes simultaneous subordination to nature and control over it, an analysis of the processes and mechanisms that underlie the formation of STL as an explication of the ecological technosphere was carried out.Results. The presented manuscript presents the results of the philosophical analysis of the STEEL construct as an explication of the ecological technosphere and the anthropoecological system as a whole. In the course of this study, the formation of STL was considered through the prism of industrial revolutions, and the main prospects for further interaction between the technosphere and the ecosphere were identified.Conclusions. Conducting an interdisciplinary analysis of the role of the technosphere as a determining factor in the development and formation of all other technical systems and products is an urgent and significant problem. A comprehensive study of the ecological technosphere as the basic context of the formation of STL is necessary, due to the fact that it created the prerequisites for the emergence of artificial intelligence and convergent technologies, which currently determine global economic, cultural, social and industrial trends.
Identifying Personality Characteristics and Indicators of Psychological Well-Being Associated With Attrition in the Motivation Makes the Move! Physical Activity Intervention: Randomized Technology-Supported Trial
Authors: Kaseva Kaisa , Tervaniemi Mari , Heikura Enni , Kostilainen Kaisamari , Pöyhönen-Alho Maritta , Shoemaker J Kevin , Petrella Robert J , Peltonen Juha E 
Published: June 2022

Background
Data attrition has been a common problem in longitudinal lifestyle interventions. The contributors to attrition in technology-supported physical activity interventions have not been thoroughly studied.

Objective
The present study examined the roles of personality characteristics and indicators of psychological well-being in data attrition within a technology-supported, longitudinal intervention study with overweight adults.

Methods
Participants (N=89) were adults from the Motivation Makes the Move! intervention study. Data attrition was studied after a 3-month follow-up. Participants’ personality characteristics were studied using the Short Five self-report questionnaire. Psychological well-being indicators were assessed with the RAND 36-item health survey, Positive and Negative Affect Schedule, and Beck Depression Inventory. Logistic regression analyses were conducted to assess the risk of discontinuing the study. The analyses were adjusted for sex, age, study group, and educational status.

Results
At the 3-month follow-up, 65 of 89 participants (73% of the initial sample) had continued in the study. Participants’ personality characteristics and indicators of psychological well-being were not associated with the risk of dropping out of the study (all P values >.05). The results remained the same after covariate controls.

Conclusions
Participant attrition was not attributable to personality characteristics or psychological well-being in the Motivation Makes the Move! study conducted with overweight adults. As attrition remains a challenge within longitudinal, technology-supported lifestyle interventions, attention should be paid to the potentially dynamic natures of personality and psychological well-being, as well as other elements beyond these.

Trial Registration
ClinicalTrials.gov NCT02686502; https://clinicaltrials.gov/ct2/show/NCT02686502
The Socio-economic Conditions of Fishers on Indonesia's Beeng Laut Island
Authors: Sarapil Costantein Imanuel , Kumaseh Eunike Irene , Mozes Getruida Nita 
Published: June 2022

This study aimed to determine the socio-economic conditions related to marketing margins of demersal fish in Beeng Laut Island, Sangihe Archipelago Regency, North Sulawesi Province, Indonesia, using survey methods with interview and questionnaire techniques. Most fishers on Beeng Laut Island have a primary school education, houses constructed using wood, and an age range of 20 to 30 years. Margin marketing demersal fish on Channel marketing III (P à Pp à Pe à Ka) and Channel IV (P à Pp à Rm à Ka) is inefficient due to the limited electricity supply. This has an indirect effect on fish quality due to a lack of readily available ice to handle catches. Increased demersal fish marketing efficiency may result in a significant revenue for fishers. Therefore, the government should boost energy availability to enable people create and purchase ice to aid with fish preservation. It should also establish cooperatives for fishers and provide alternative work, such as conservation activities or marine tourism development.
Chemo protective activity of Phyllanthus niruri and Opuntia ficus indica plant extract
Authors: Sharma Krati , Malviya Rajeev , Gupta Vishal 
Published: June 2022

Cancer is one of the leading causes of death. Several chemotherapeutical agents have been used to treat cancer, and yet a convincing cure is elusive in most cases. Therefore, there is continued need for development of new anticancer agents. Angiogenesis is one of the vital events for organ development and differentiation during embryogenesis as well as wound healing and reproductive functions in adults. Angiogenesis also contributes significantly to tumors growth and metastasis. Currently, search for effective anti-angiogenesis agents and therapy is an emerging field. Cytotoxic agents with anti-angiogenic activity are designated to control tumors endothelial cell growth and tumour cell survival. Therefore, combinatorial therapy in which anti-angiogenic agents with chemotherapeutic activity administrated in a scheduled manner could result in a much more favorable therapeutic effect. India is one of the richest bio diversity centers with respect to medicinal plants. Many plants have been utilized in the traditional system of medicine for cancer treatment. The plants have been utilized as medicines from thousands of years ago. The isolation of active components from plants began with the morphine isolation from opium plant. In the present study, Phyllanthus niruri and Opuntia ficus-indica were screened for the phytochemical and anticancer evaluation.
Keywords: Anti-Cancer, Anti-Oxidant, Phyllanthus niruri, Opuntia ficus-indica, in vivo study.
Civil Revolution: User Experiences with British Columbia’s Online Court
Authors: Sykes Katie , Dickson Rebecca , Ewart Sarah , Foulkes Candice , Landry Marina 
Published: June 2022

British Columbia’s new Civil Resolution Tribunal [CRT] is a primarily online dispute resolution system that has attracted international attention for its innovative approach. But so far there has been little independent research on the effectiveness of the CRT and similar online dispute resolution initiatives in providing access to justice. In a qualitative and exploratory study, we surveyed 49 British Columbians who had used the CRT about their experience with the process. Overall, the results suggest that the CRT has improved access to justice, but the survey answers also identified problems and concerns, for which we suggest potential solutions.
As the Water Grinds the Stone: Comparison of Represented and Self-represented Appellant Populations in the Federal Court of Appeal
Authors: Netolitzky Donald J. , Warman Richard 
Published: June 2022

This article reports a quantitative and statistically reliable population investigation of 552 Federal Court of Appeal proceedings that were appeals by represented and self-represented appellants who, in 2016 or 2017, appealed decisions of the Federal Court or Tax Court of Canada. Appeals by the Crown, non-Crown represented appellants, and self-represented appellants exhibited markedly different frequencies at which appeals were granted, and patterns for how appeals were terminated. Nearly half of Crown appeals were granted, but less than one in twenty self-represented appellants had any degree of success. While 70% of appeals conducted by lawyers completed the appeal process, less than 40% of self-represented appellant proceedings resulted in a full appeal panel hearing. Incomplete appeals by self-represented appellants usually terminated prior to the appeal record stage, and typically were either abandoned or discontinued. The time required to complete appeals for represented and self-represented appellants is similar. The high observed frequency of problematic litigation records for self-represented appellants supports the hypothesis that a “Distillation Effect” is concentrating abusive litigants in appellate forums.
High resolution investigation of self-represented appellant subgroups revealed differences within the overall self-represented appellant population. Self-represented appellants emerging from the Federal Court and Tax Court of Canada are different populations. The former were much more likely to have an abusive litigation history, while the latter voluntarily discontinued appeals, and were never subject to Federal Court of Appeal vexatious litigant management steps. Self-represented appellant proceedings that terminated prematurely or that were conducted by persons who are subject to court access restrictions had significantly more filed documents and docket records. Litigation management steps did not reduce the Registry and Court workload resulting from self-represented appellants subject to court access restrictions. These observations challenge modelling self-represented litigants as a single population with uniform characteristics.
Perlindungan Hukum dalam Kegiatan Investasi Bagi Pemilik Modal di Kota Jambi
Authors: Indah Sari Resi , Herlina Nelli 
Published: June 2022

This article discusses about the legal protection of capital owners in the investment activities in Jambi City which is based on the regional regulation of Jambi city as well as obstacles faced by investment actors in the implementation of capital investment in Jambi City. This discussion is necessary because the development of investmentin the city of Jambi is increasing in line with the development of the time in line with the law number 25 in 2007 on investment that was formed as the basis of consideration is to accelerate the development of national economy and realize Indonesia's political and economic sovereignty. This research is using juridical research method empirical with results that shows the legal protection of capital owners in investment activities has been supported through the Department of Investment and Integrated services Jambi to facilitate the owner of capital in obtaining business licenses. Constraints encountered by capital owners in the activities of capital keeping in Jambi city caused by the number of licensing requirements that must be fulfilled by the capital owner to start the business and Online Single Submission (OSS) system that has not been carried out with maximum because the owner of the capital remains to carry out the licensing manually and independently to the government agencies authorized to issue operational licenses of the company.
Keywords: Legal; Protection; Investment;

Abstrak
Artikel ini membahas bagaimana perlindungan hukum terhadap pemilik modal dalam kegiatan investasi di Kota Jambi yang didasarkan pada Peraturan Daerah Kota Jambi serta kendala yang dihadapi pelaku investasi dalam pelaksanaan kegiatan penanaman modal di Kota Jambi. Pembahasan ini diperlukan karena perkembangan iklim investasi di Kota Jambi yang semakin meningkat sejalan dengan perkembangan zaman sejalan dengan Undang-Undang Nomor 25 Tahun 2007 tentang Penanaman Modal yang dibentuk sebagai dasar pertimbangan yaitu untuk mempercepat pembangunan ekonomi nasional dan mewujudkan kedaulatan politik dan ekonomi Indonesia. Penelitian ini menggunakan metode penelitian yuridis empiris dengan hasil yang menunjukan perlindungan hukum terhadap pemilik modal dalam kegiatan investasi telah di tunjang melalui Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Jambi untuk memudahkan pemilik modal dalam memperoleh izin usaha. Kendala yang ditemui pemilik modal dalam kegiatan penaman modal di Kota Jambi disebabkan banyaknya persyaratan perizinan yang harus dipenuhi oleh pemilik modal untuk memulai usaha serta sistem Online Single Submission (OSS) yang belum terlaksana dengan maksimal karena pemilik modal tetap harus melakukan perizinan secara manual dan tersendiri ke instansi pemerintah yang berwenang dalam mengeluarkan izin operasional perusahaan.
Kata kunci: Perlindungan; Hukum; Investasi