bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation of a super-dense hydrogen monolayer on mesoporous silica
Authors: Balderas-Xicohténcatl Rafael , Lin Hung-Hsuan , Lurz Christian , Daemen Luke , Cheng Yongqiang , Cychosz Struckhoff Katie , Guillet-Nicolas Remy , Schütz Gisela , Heine Thomas , Ramirez-Cuesta Anibal J. , Thommes Matthias , Hirscher Michael 
Published: August 2022

AbstractAdsorption on various adsorbents of hydrogen and helium at temperatures close to their boiling points shows, in some cases, unusually high monolayer capacities. The microscopic nature of these adsorbate phases at low temperatures has, however, remained challenging to characterize. Here, using high-resolution cryo-adsorption studies together with characterization by inelastic neutron scattering vibration spectroscopy, we show that, near its boiling point (~20 K), H2 adsorbed on a well-ordered mesoporous silica forms a two-dimensional monolayer with a density more than twice that of bulk-solid H2, rather than a bilayer. Theoretical studies, based on thorough first-principles calculations, rationalize the formation of such a super-dense phase. The strong compression of the hydrogen surface layer is due to the excess of surface–hydrogen attraction over intermolecular hydrogen repulsion. Use of this super-dense hydrogen monolayer on an adsorbent might be a feasible option for the storage of hydrogen near its boiling point, compared with adsorption at 77 K.
Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma
Authors: Scholler Nathalie , Perbost Regis , Locke Frederick L. , Jain Michael D. , Turcan Sarah , Danan Corinne , Chang Edmund C. , Neelapu Sattva S. , Miklos David B. , Jacobson Caron A. , Lekakis Lazaros J. , Lin Yi , Ghobadi Armin , Kim Jenny J. , Chou Justin , Plaks Vicki , Wang Zixing , Xue Allen , Mattie Mike , Rossi John M. , Bot Adrian , Galon Jérôme 
Published: August 2022

AbstractAxicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor (CAR) T cell therapy approved for relapsed/refractory large B cell lymphoma (LBCL) and has treatment with similar efficacy across conventional LBCL subtypes. Toward patient stratification, we assessed whether tumor immune contexture influenced clinical outcomes after axi-cel. We evaluated the tumor microenvironment (TME) of 135 pre-treatment and post-treatment tumor biopsies taken from 51 patients in the ZUMA-1 phase 2 trial. We uncovered dynamic patterns that occurred within 2 weeks after axi-cel. The biological associations among Immunoscore (quantification of tumor-infiltrating T cell density), Immunosign 21 (expression of pre-defined immune gene panel) and cell subsets were validated in three independent LBCL datasets. In the ZUMA-1 trial samples, clinical response and overall survival were associated with pre-treatment immune contexture as characterized by Immunoscore and Immunosign 21. Circulating CAR T cell levels were associated with post-treatment TME T cell exhaustion. TME enriched for chemokines (CCL5 and CCL22), γ-chain receptor cytokines (IL-15, IL-7 and IL-21) and interferon-regulated molecules were associated with T cell infiltration and markers of activity. Finally, high density of regulatory T cells in pre-treatment TME associated with reduced axi-cel–related neurologic toxicity. These findings advance the understanding of LBCL TME characteristics associated with clinical responses to anti-CD19 CAR T cell therapy and could foster biomarker development and treatment optimization for patients with LBCL.
Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating
Authors: Shivacharan Rajat S. , Rolle Camarin E. , Barbosa Daniel A. N. , Cunningham Tricia N. , Feng Austin , Johnson Noriah D. , Safer Debra L. , Bohon Cara , Keller Corey , Buch Vivek P. , Parker Jonathon J. , Azagury Dan E. , Tass Peter A. , Bhati Mahendra T. , Malenka Robert C. , Lock James D. , Halpern Casey H. 
Published: August 2022

AbstractCravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology during food cravings preceding LOC eating in two patients with BED and severe obesity (trial registration no. NCT03868670). Increased NAc low-frequency oscillations, prominent during food cravings, were used to guide DBS delivery. Over 6 months, we observed improved self-control of food intake and weight loss. These findings provide early support for restoring inhibitory control with electrophysiologically-guided NAc DBS. Further work with increased sample sizes is required to determine the scalability of this approach.
Multi-queen breeding is associated with the origin of inquiline social parasitism in ants
Authors: Dahan Romain A. , Rabeling Christian 
Published: August 2022

AbstractSocial parasites exploit the brood care behavior of their hosts to raise their own offspring. Social parasites are common among eusocial Hymenoptera and exhibit a wide range of distinct life history traits in ants, bees, and wasps. In ants, obligate inquiline social parasites are workerless (or nearly-so) species that engage in lifelong interactions with their hosts, taking advantage of the existing host worker forces to reproduce and exploit host colonies’ resources. Inquiline social parasites are phylogenetically diverse with approximately 100 known species that evolved at least 40 times independently in ants. Importantly, ant inquilines tend to be closely related to their hosts, an observation referred to as ‘Emery’s Rule’. Polygyny, the presence of multiple egg-laying queens, was repeatedly suggested to be associated with the origin of inquiline social parasitism, either by providing the opportunity for reproductive cheating, thereby facilitating the origin of social parasite species, and/or by making polygynous species more vulnerable to social parasitism via the acceptance of additional egg-laying queens in their colonies. Although the association between host polygyny and the evolution of social parasitism has been repeatedly discussed in the literature, it has not been statistically tested in a phylogenetic framework across the ants. Here, we conduct a meta-analysis of ant social structure and social parasitism, testing for an association between polygyny and inquiline social parasitism with a phylogenetic correction for independent evolutionary events. We find an imperfect but significant over-representation of polygynous species among hosts of inquiline social parasites, suggesting that while polygyny is not required for the maintenance of inquiline social parasitism, it (or factors associated with it) may favor the origin of socially parasitic behavior. Our results are consistent with an intra-specific origin model for the evolution of inquiline social parasites by sympatric speciation but cannot exclude the alternative, inter-specific allopatric speciation model. The diversity of social parasite behaviors and host colony structures further supports the notion that inquiline social parasites evolved in parallel across unrelated ant genera in the formicoid clade via independent evolutionary pathways.
Gradual enhancement of corticomotor excitability during cortico-cortical paired associative stimulation
Authors: Turrini Sonia , Fiori Francesca , Chiappini Emilio , Santarnecchi Emiliano , Romei Vincenzo , Avenanti Alessio 
Published: August 2022

AbstractCortico-cortical paired associative stimulation (ccPAS) is an effective transcranial magnetic stimulation (TMS) method for inducing associative plasticity between interconnected brain areas in humans. Prior ccPAS studies have focused on protocol’s aftereffects. Here, we investigated physiological changes induced “online” during ccPAS administration. We tested 109 participants receiving ccPAS over left ventral premotor cortex (PMv) and primary motor cortex (M1) using a standard procedure (90 paired-pulses with 8-ms interstimulus interval, repeated at 0.1 Hz frequency). On each paired-pulse, we recorded a motor-evoked potential (MEP) to continuously trace the emergence of corticomotor changes. Participant receiving forward-ccPAS (on each pair, a first TMS pulse was administered over PMv, second over M1, i.e., PMv-to-M1) showed a gradual and linear increase in MEP size that did not reach a plateau at the end of the protocol and was greater in participants with low motor threshold. Participants receiving reverse-ccPAS (i.e., M1-to-PMv) showed a trend toward inhibition. Our study highlights the facilitatory and inhibitory modulations that occur during ccPAS administration and suggest that online MEP monitoring could provide insights into the malleability of the motor system and protocol’s effectiveness. Our findings open interesting prospects about ccPAS potential optimization in experimental and clinical settings.
Increased sympathetic modulation in breast cancer survivors determined by measurement of heart rate variability
Authors: Majerova Karolina , Zvarik Milan , Ricon-Becker Itay , Hanalis-Miller Tsipi , Mikolaskova Iveta , Bella Vladimir , Mravec Boris , Hunakova Luba 
Published: August 2022

AbstractExperimental and clinical studies have shown that the sympathetic nervous system (SNS) stimulates cancer progression and reduces the efficacy of oncological treatment. These effects may be reduced by pharmacological and psychotherapeutical approaches attenuating SNS tone. Therefore, it is necessary to identify those cancer survivors whose sympathetic modulation is excessively increased. For determination of SNS modulation, non-invasive method of heart rate variability (HRV) is widely used. In our study, HRV was determined from 5-min heartbeat recordings in healthy volunteers and in women with benign or malignant breast neoplasias, both in newly diagnosed patients and in women after initial treatment. We showed impaired cardio-vagal regulation in breast cancer patients (linear methods) and also found the increased sympathetic modulation indicated by the non-linear (the symbolic dynamics 0V%) parameter. This non-linear HRV analysis seems to be more sensitive than the linear one, indicating significant differences also in survivors after initial therapy in comparison to healthy controls. The lower sample entropy revealed reduced complexity in heart rate control in both breast cancer survivors groups. These findings suggest that HRV detection represents an inexpensive, easy, and reliable method for identification of those patients with breast cancer whose sympathetic modulation is significantly increased and in which the interventions, aimed at normalizing the balance in the autonomic nervous system (e.g. psychotherapy, biofeedback, treatment by β-blockers) may be the most effective.
Mechanical properties and mechanism of soil treated with nano-aqueous adhesive (NAA)
Authors: Huang Wei , Du Jiaxin , Lai Haoqiang , Zhang Qingxiu , Zhou Cuiying , Liu Zhen 
Published: August 2022

AbstractThe loose structure and low mechanical strength of the surface soil make it vulnerable to damage under erosion conditions. Slope ecological protection is one of the effective methods to improve the stability of slope soil. Although it has been proved that polymer modified materials can effectively improve the soil properties and the environmental protection effect of slope, so far, the improvement mechanism has not been fully understood, especially the chemical mechanism of the material on the enhancement of soil mechanical properties is not clear. In the present study, the effects of nano-aqueous adhesive (NAA) on unconfined compressive strength, shear strength and aggregate characteristics of soil were studied by a series of laboratory experiments. The results show that NAA can increase the strength, aggregate number and stability of the soil, to effectively improve the stability of surface soil. In addition, through infrared spectroscopy and SEM test, it was found that NAA molecules were mainly distributed in the interlayer position of flaky clay minerals, mainly connected with clay minerals through hydrogen bonds, thereby effectively enhancing the cohesion of soil particles.
Inhibitory effects of Serjania erecta on the development of Chrysodeixis includens
Authors: de Freitas Samylla Tassia Ferreira , Rodrigues Agna Rita dos Santos , Ataídes Ana Cláudia Cardoso , de Oliveira Menino Gisele Cristina , de Faria Giselle Santos , Vitorino Luciana Cristina , Silva Fabiano Guimarães , Dyszy Fábio Henrique 
Published: August 2022

AbstractThe soybean looper, Chrysodeixis includens, is a primary soybean pest that reduces crop productivity. This work examined control of C. includens populations with methanolic extract of Serjania erecta, a native Cerrado plant, while minimizing risks to pollinators, natural enemies and the environment. Serjania erecta specimens were collected, identified, and subjected to methanol extraction. Bioassays were performed using newly hatched and second-instar caterpillars and different extract concentrations on the diet surface to obtain IC50 values. Two replicates, containing 10 caterpillars, were established in triplicate. The IC50 values were 4.15 and 6.24 mg of extract mL−1 for first-instar and second-instar caterpillars, respectively. These growth inhibition results informed the extract concentrations assessed in subsequent development inhibition assays, in which the pupal weight was higher under the control than under the treatments. Extract treatments increased the duration of the larval, pupal and total development. The potential of different concentrations of S. erecta extract to inhibit the enzymes carboxylesterases was also evaluated. Carboxylesterases activity decreased by 41.96 and 43.43% at 7.8 and 15.6 μg mL−1 extract, respectively. At 31.3 μg mL−1 extract, enzymatic activity was not detected. Overall, S. erecta leaf methanolic extract showed inhibitory potential against carboxylesterases.
Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip
Authors: Pang Luping , Zanki Vladimir , Strelkov Sergei V. , Van Aerschot Arthur , Gruic-Sovulj Ita , Weeks Stephen D. 
Published: August 2022

AbstractTo correctly aminoacylate tRNALeu, leucyl-tRNA synthetase (LeuRS) catalyzes three reactions: activation of leucine by ATP to form leucyl-adenylate (Leu-AMP), transfer of this amino acid to tRNALeu and post-transfer editing of any mischarged product. Although LeuRS has been well characterized biochemically, detailed structural information is currently only available for the latter two stages of catalysis. We have solved crystal structures for all enzymatic states of Neisseria gonorrhoeae LeuRS during Leu-AMP formation. These show a cycle of dramatic conformational changes, involving multiple domains, and correlate with an energetically unfavorable peptide-plane flip observed in the active site of the pre-transition state structure. Biochemical analyses, combined with mutant structural studies, reveal that this backbone distortion acts as a trigger, temporally compartmentalizing the first two catalytic steps. These results unveil the remarkable effect of this small structural alteration on the global dynamics and activity of the enzyme.
Bacteria-plant interactions synergistically enhance biodegradation of diesel fuel hydrocarbons
Authors: Eze Michael O. , Thiel Volker , Hose Grant C. , George Simon C. , Daniel Rolf 
Published: August 2022

AbstractThe biotechnological application of microorganisms for rhizoremediation of contaminated sites requires the development of plant-microbe symbionts capable of plant growth promotion and hydrocarbon degradation. Here, we present a study aimed at isolating single microbial strains that are capable of promoting plant growth as well as rhizoremediation of diesel fuel hydrocarbons. Through genomic analyses and greenhouse-based experiments, we examined the synergistic interactions ofMedicago sativaL. andParaburkholderia tropicaWTPI1 for enhanced rhizoremediation of diesel fuel-contaminated soils. Plant growth-based experiments confirmed that the inoculation ofM. sativawithP. tropicaled to a 99% increase in plant biomass. Furthermore, organic geochemical analysis revealed that 96% of all the distinctive diesel fuel hydrocarbons, including C10–C25n-alkanes, branched alkanes, cycloalkanes and aromatic hydrocarbons were degraded in theM. sativa + P. tropicatreatment. These results will prove beneficial for biotechnological application ofP. tropicaWTPI1 for plant growth promotion and most importantly for environmental remediation of organic pollutants.
Real-Ear-to-Coupler Difference: Physical and Perceptual Differences
Authors: Jorgensen Lindsey , Barrett Rachel , Jedlicka David , Messersmith Jessica , Pratt Sheila 
Published: August 2022

Purpose:
The real-ear-to-coupler difference (RECD) is a recommended measure for accurate hearing aid fittings, especially for pediatric populations. However, for adults, many clinicians question whether it is necessary.

Method:
Hearing aids were fit on two groups of 85 older adults seen at a Veterans Administration audiology clinic. One group was fit using RECD measurements, whereas the second group was fit with population-based average RECD values. The two groups had similar pure-tone hearing thresholds.

Results:

Like previous studies, there was little difference between the measured RECD for the right and left ears among the participants. Although the majority of the measured RECDs were within 1
SD
of the mean, approximately 20% of those measured were outside of the normal range. It also was found that all participants produced lower (improved) Hearing Handicap Inventory for Elderly–Screening (HHIE-S) scores from pre- to postfitting, thus suggesting a reduction in self-perceived hearing handicap.

Conclusions:
Despite having similar prefitting HHIE-S scores, those participants who had their hearing aids fit using measured RECD values had lower postfitting scores than the group that was fit with average RECD values. Furthermore, there was a significant difference between the groups on several questions of the International Outcome Inventory–Hearing Aids, suggesting that there was higher satisfaction with the fittings based on the custom RECD rather than the fittings based on the average RECD. This study demonstrated that, in addition to performing verification using real-ear measurements, accurate conversion of dB HL to dB SPL using personalized RECD likely improved hearing aid satisfaction.
Long Latency Auditory Evoked Responses in the Identification of Children With Central Auditory Processing Disorders: A Scoping Review
Authors: Macaskill Melissa , Omidvar Shaghayegh , Koravand Amineh 
Published: August 2022

Purpose:
The long latency auditory evoked responses (LLAERs), originating in the auditory cortex, are often considered a biomarker for maturity in the central auditory system and may therefore be useful in the evaluation of children with central auditory processing disorder (CAPD). However, the characteristics of the LLAERs elicited in this population have not been widely described, and clinical applications remain unclear. The goal of this scoping review was to investigate if LLAERs can be used to identify children with CAPD.

Method:
A systematic search strategy was used to identify studies that analyzed the latencies and amplitudes of P1, N1, P2, and N2 waveforms of the LLAERs. The online databases, including Embase, Web of Science, MEDLINE, PubMed, ProQuest, and CINAHL, as well as the gray literature were searched for papers published in English and French between January 1980 and May 2021.

Results:
Seventeen papers met the eligibility criteria and were included in the study. Four papers had pre- and posttraining study designs, and the remaining studies were cross-sectional. Several studies reported significant differences in LLAERs between children with CAPD and their normal-hearing peers, and the results tended toward longer latencies and smaller amplitudes regardless of LLAER waves considered. N1 and/or N2 results were most likely to reveal significant differences between children with CAPD and normal-hearing controls and could potentially be considered a biomarker for CAPD.

Conclusions:
It seems that LLAER assessments, especially waves N1 and N2, might assist in better identification of CAPD children. However, considering heterogeneity in the methodology among the included studies, the results should be interpreted with caution. Well-designed studies on children with confirmed CAPD using standard diagnostic and assessment protocols are suggested.
Incentive Stackelberg game for H∞$H_\infty$‐constrained multi‐hierarchy systems under observation information
Authors: Li Xiaoqian , Bai Mengyu , Zhang Huanshui , Jing Zonglei , Ju Peijun , Guo Zhongjin 
Published: August 2022

AbstractThis paper considers the incentive feedback Stackelberg game with multi‐hierarchy players under a constraint, with the proposed solution involving nested hierarchies A and B. In hierarchy A, P0 represents the leader (the leader's control input corresponding to i‐th follower, ), and are the followers, with non‐cooperative followers induced to virtually cooperate in achieving team‐optimal solution and the Nash equilibrium. In hierarchy B, the external disturbance represents the follower, and hierarchy A represents the leader. The main contributions of this work are three‐fold. First, an incentive Stackelberg strategy set under the constraint through observation information is obtained for the first time. Second, a novel iterative algorithm to solve the coupled backward and forward Riccati equations is introduced and thus obtaining an explicit expression of a team‐optimal feedback Stackelberg strategy set with an constraint. Finally, the necessary and sufficient conditions for the existence and uniqueness of the hierarchical game's optimal solutions using the Lyapunov equation and the induction algorithm are presented.
Spatially resolved gas and stellar kinematics in compact starburst galaxies
Authors: Bik A. , Östlin G. , Hayes M. , Melinder J. , Menacho V. 
Published: August 2022

Context.The kinematics of galaxies provide valuable insights into their physics and assembly history. Kinematics are governed not only by the gravitational potential, but also by merger events and stellar feedback processes such as stellar winds and supernova explosions.Aims.We aim to identify what governs the kinematics in a sample of SDSS-selected nearby starburst galaxies, by obtaining spatially resolved measurements of the gas and stellar kinematics.Methods.We obtained near-infrared integral-fieldK-band spectroscopy with VLT/SINFONI for 15 compact starburst galaxies. We derived the integrated as well as spatially resolved stellar and gas kinematics. The stellar kinematics were derived from the CO absorption bands, and Paαand Brγemission lines were used for the gas kinematics.Results.Based on the integrated spectra, we find that the majority of galaxies have gas and stellar velocity dispersion that are comparable. A spatially resolved comparison shows that the six galaxies that deviate show evidence for a bulge or stellar feedback. Two galaxies are identified as mergers based on their double-peaked emission lines. In our sample, we find a negative correlation between the ratio of the rotational velocity over the velocity dispersion (vrot/σ) and the star formation rate surface density.Conclusions.We propose a scenario where the global kinematics of the galaxies are determined by gravitational instabilities that affect both the stars and gas. This process could be driven by mergers or accretion events. Effects of stellar feedback on the ionised gas are more localised and detected only in the spatially resolved analysis. The mass derived from the velocity dispersion provides a reliable mass even if the galaxy cannot be spatially resolved. The technique used in this paper is applicable to galaxies at low and high redshift with the next generation of infrared-focussed telescopes (JWST and ELT).