bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PO-113: Overall survival in ovarian cancer patients seeking care at more than one treatment facility
Authors: Deveaux April , Islam Jessica , Akinyemiju Tomi 
Published: January 2022

Abstract
Purpose: Ovarian cancer is the most lethal gynecological cancer and despite advances in treatment, most patients are diagnosed at an advanced stage with poor prognosis. Black women have a lower 5 year survival than White women when diagnosed at the same stage, and while there are a number of contributing factors, quality of treatment center may play a significant role. Choice in treatment facility may be limited by insurance coverage, availability of high-volume hospitals or specialists, or ability to access high-quality facilities, and it is unclear how a change in treatment facility may impact ovarian cancer survival. Methods: Participant usage files from the National Cancer Database were used to interrogate the characteristics of patients that seek treatment at more than one Commission on Cancer accredited facility in the United States to determine the effect on overall survival. Multivariable Cox regression analysis models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI) to determine risk of mortality for patients receiving all of their first course treatment at one facility vs those receiving first course treatment at more than one facility. The fully-adjusted model was then stratified by race/ethnicity (Non-Hispanic White, Non-Hispanic Black, Hispanic) and by facility type (Community, Comprehensive Community, Academic/Research, Integrative Network). Results: A total of 211,937 women were included in the analysis. Patients were more likely to receive all of their first course treatment at one facility (81%). Patents treated at more than one facility had a 26% increase in ovarian cancer mortality compared with those treated at a single facility (HR: 1.26, 95% CI: 1.24-1.28). When stratified by race, NH-Black patients had the lowest increase in overall survival (HR: 1.08, 95% CI: 1.03-1.14) when compared with NH-White (HR: 1.27, 95% CI: 1.25-1.29) and Hispanic (HR: 1.33, 95% CI: 1.28-1.39) patients. Stratification by facility type showed that among women receiving treatment at more than one facility, those switching to an academic research center had the highest mortality (HR: 1.31, 95% CI: 1.28-1.34). Conclusions: Ovarian cancer patients that received treatment at more than one facility had a higher rate of mortality than those who were treated at a single center. Our findings suggest the need for further investigation into the effects of continuity of care, including how race, facility type, and other socioeconomic factors may modulate those effects.
Citation Format: April Deveaux, Jessica Islam, Tomi Akinyemiju. Overall survival in ovarian cancer patients seeking care at more than one treatment facility [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-113.
Abstract PO-118: Patient and county level determinants of surgical treatment for non-small cell lung cancer: A SEER-Medicare analysis
Authors: Odahowski Cassie Lewis , Alberg Anthony J. , Schootman Mario , Zhang Jiajia , Eberth Jan M. 
Published: January 2022

Abstract
Introduction: Rural lung cancer patients experience worse survival than urban lung cancer patients. Worse survival in early-stage rural lung cancer patients may be due lower utilization of surgical treatment compared to their urban counterparts. We examined patient- and county-level determinants of surgical treatment for non-small cell lung cancer, focusing on rural vs. urban disparities. Methods: Our sample included 63,767 localized and regional NSCLC cases diagnosed between 2003-2011 using SEER-Medicare data. Predictors examined included demographics, clinical characteristics, and county factors (urban versus rural designation, percent of the population ≥65 years old below 100% Federal Poverty Limit, and designation as a Medically Underserved Area). Patient characteristics were nested within counties in multilevel logistic regression models stratified by stage at diagnosis, predicting receipt of surgical treatment. Results: Rural residents were less likely to receive surgical treatment than urban residents (42.0% vs. 46.8%, p&lt;0.01), and black patients were less likely than white patients to receive surgery (32.9% vs. 47.1%, p&lt;0.01). Rurality did not remain a significant factor in the final adjusted model. The final model showed an odds of surgical treatment decreased for every 5% increase in county-level poverty for both local stage (OR=0.83, 95% CI:0.77-0.91) and regional stage (OR=0.84, 95%CI: 0.79-0.90). Other patient factors associated with lower likelihood of surgical treatment included older age, male sex, non-married, dual Medicare/Medicaid enrollment, and more comorbidities. Conclusions: Rurality was not associated with receipt of surgery in the final multilevel model, but patient race and county-level poverty were significantly associated with a lower odds of surgery. Future research is needed to understand the causes of these disparities in surgical treatment of lung cancer to maximize survival for all populations.
Citation Format: Cassie Lewis Odahowski, Anthony J. Alberg, Mario Schootman, Jiajia Zhang, Jan M. Eberth. Patient and county level determinants of surgical treatment for non-small cell lung cancer: A SEER-Medicare analysis [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-118.
Abstract PO-128: Completion of nipple reconstruction in triple-negative breast cancer patients compared to triple-positive breast cancer patients: A single institutional analysis
Authors: Amaya Joshua , Jones Kaitlin , Haddock Nicholas T. , Teotia Sumeet S. 
Published: January 2022

Abstract
Background: Triple-negative (TN) breast cancer is considered to be more aggressive than other subtypes of breast cancer and has a poorer prognosis. It is defined as breast cancer tumors that lack estrogen receptor (ER), progesterone receptor (PR), and HER2 expression and affects 17-20% of women with breast cancer. However, reconstructive outcomes remain to be elucidated when compared to other invasive breast cancer subtypes. The aim of this study is to determine if there is a disparity in completing nipple-areolar reconstruction in breast cancer patients with a triple-negative subtype compared to patients with a triple-positive (TP) subtype. Methods: 107 patients who underwent bilateral non-nipple sparing mastectomies from 2013 to 2017 diagnosed with a TN (n = 54) and TP (n = 53) invasive breast cancer subtype were identified. All 107 patients were seen by two attending surgeons at a single institution. Completion of nipple reconstruction and areolar tattoos, number of days from mastectomy to nipple reconstruction, and areolar tattoos were analyzed. Demographic/clinical variables, including race, age, BMI, smoking, comorbidities, neoadjuvant/adjuvant chemotherapy, hormonal therapy, radiation therapy, and choice of implants or flaps were also analyzed. Results: There was no significant difference in the proportion of patients who underwent radiation therapy in the TN group than in the TP group (55.56% vs 37.74%, p = 0.0819). Among these two groups, there was no significant difference in the percentage of patients completing nipple reconstruction (TN = 44.44%, TP = 49.06%, p = 0.7001) and acquiring an areolar tattoo (TN = 33.33%, TP = 39.62%, p = 0.5503). The differences in the average duration in days from mastectomy to nipple reconstruction (TN = 505.7, TP = 456.4, p = 0.5259) and areolar tattoos (TN = 665.6, TP = 638.5, p = 0.7653) among these two patient populations were also insignificant. Conclusion: TN subtype does not make a significant impact on completing nipple reconstruction when compared to TP patients, another extreme. These results should be considered when counseling TN patients on their reconstructive journey.
Citation Format: Joshua Amaya, Kaitlin Jones, Nicholas T. Haddock, Sumeet S. Teotia. Completion of nipple reconstruction in triple-negative breast cancer patients compared to triple-positive breast cancer patients: A single institutional analysis [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-128.
Abstract PO-135: The effects of DCLK1 isoform 2 upon the migration and invasion capabilities of colorectal cancer cells
Authors: Brown Valeria , Li Lianna 
Published: January 2022

Abstract
Double Cortin-like Kinase 1 (DCLK1) is a cancer stem cell (CSC) marker that is over-expressed in CSCs and epithelial-mesenchymal transition (EMT) cells of many cancers. Due to its expression in the chemoresistant, tumorigenic subpopulation in cancer tissue, DCLK1 plays critical roles in indefinite cell proliferation, tumorigenesis, tumor metastasis, and recurrence of cancer. Further evidence has shown that the deregulation or inhibition of DCLK1 directly causes a decrease in cancer succession and reduces the possibility of relapse. DCLK1 has five isoforms and association of each isoform with human colorectal cancer (hCRC) is unclear. For the current project, we aim to reveal correlation of the DCLK1 isoform 2 (DCLK1-S) with invasion and migration capability of hCRC cells. In order to achieve our goal, we established the isogenic DCLK1-S over-expression cells using the HCT116 cell line, performed the scratching assay, and used ImageJ software to determine the wound healing speed of DCLK1-S over-expression cells and HCT116 cells. Our preliminary results demonstrated that DCLK1-S was not associated with increased migration and invasion capability of hCRC cells. Compared to the HCT116 cells, the wound healing speed of DCLK1-S over-expression cells significantly decreased (P&lt;0.05). Therefore, the DCLK1-S might not change migration and invasion capabilities of hCRC cells. In the future, we will further confirm our findings and will determine whether DCLK1-S affect stemness of hCRC CSCs and EMTs from other aspects.
Citation Format: Valeria Brown, Lianna Li. The effects of DCLK1 isoform 2 upon the migration and invasion capabilities of colorectal cancer cells [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-135.
Abstract PO-144: Functional characterization of estrogen-regulated divergent long noncoding RNAs in estrogen receptor-positive breast cancer
Authors: Ramos Enrique I. , Sanchez-Michael Laura A. , Sedano Melina J. , Yang Barbara , Choudhari Ramesh , Harrison Alana L. , Gadad Shrikanth S 
Published: January 2022

Abstract
Introduction/background: Recent studies have shown that long noncoding RNAs (lncRNAs) could be potential biomarkers and therapeutic targets in cancer. LncRNAs are significant in regulating transcriptional, post-transcriptional, and epigenetic changes in human development. Previously, we identified ~1900 lncRNAs in breast cancer (BC) using advanced technologies including Global Run-On sequencing (GRO-seq) and subcellular fractionation RNA sequencing (RNAseq); intriguingly, many were transcribed bidirectionally, now referred to as divergent lncRNAs. Currently, little is known about their role in regulating estrogen-dependent signaling in BC. In this study, we have investigated the role of a previously annotated and characterized estrogen-regulated lncRNA known as lncRNA67. Materials and Methods: We used integrated genomics to compute expression across BC molecular subtypes. Single-molecule RNA-FISH (Fluorescence in Situ Hybridization) determined its localization in BC patient samples. The role of lncRNA67 in estrogen receptor-positive (ER+) BC cells was investigated using stably inducible lncRNA overexpressing MCF7 and T47D cell lines. Total-directional RNA-seq was performed to understand its effect on global gene expression profiles. Results: LncRNA67 showed distinct expression patterns across molecular subtypes of BC. RNA-FISH revealed nucleus and cytoplasm localization, indicating one to two copies of mature RNA are present in ER+ BC patient cells. Functional assays with reduced expression showed inhibited growth of BC cells. When lncRNA67 was overexpressed in ER+ BC cells, the result correlates with clinical outcome. Gene Set Enrichment Analysis (GSEA) showed its role in regulating estrogen-dependent transcription. Conclusion: Our molecular analyses suggest lncRNA67 plays a pivotal role in ER-dependent and -independent pathways. Taken together, our results indicate that lncRNAs are an integral component of cancer biology. Acknowledgments: S.S.G. is supported by a First-time Faculty Recruitment Award from the Cancer Prevention and Research Institute of Texas (CPRIT; RR170020). S.S.G. is also supported by a grant from Lizanell and Colbert Coldwell foundation.
Citation Format: Enrique I. Ramos, Laura A. Sanchez-Michael, Melina J. Sedano, Barbara Yang, Ramesh Choudhari, Alana L. Harrison, Shrikanth S Gadad. Functional characterization of estrogen-regulated divergent long noncoding RNAs in estrogen receptor-positive breast cancer [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-144.
Abstract PO-161: A community-based liver cancer education initiative led to healthier dietary and alcohol use behaviors among racial/ethnic minority community members
Authors: Li Tiffany , Lu Wenyue , Zhu Lin , Kim Ellen , Traub Kerry , Zhu Steven , Rubio-Torio Nathaly , Gonzalez Evelyn , Fraser Marilyn A. , Yeh Ming-Chin , Ma Grace X. , Ogunwobi Olorunseun O. , Tan Yin 
Published: January 2022

Abstract
Background: There is an increasing body of literature that suggests a relationship between modifiable dietary behaviors and alcohol use and liver cancer. We designed and implemented a culturally tailored community-based education program to promote liver cancer prevention. Methods: Through NCI funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core program, using CBPR approach, we engaged community-based organizations and community stakeholders serving underserved African, Asian, and Hispanic American communities in the Philadelphia metropolitan area and New York City. The community-based education incorporated in-person and virtual hybrid education workshops to address COVID-19 pandemic barriers. We conducted pre-education surveys and follow-up assessments at 6 months post-education. Participants' dietary behaviors, alcohol use, and sociodemographic characteristics were examined at both time points. Results: 526 participants were recruited including 92 African Americans, 247 Asian Americans, and 187 Hispanic Americans, with an average age of 59. We found that at 6-month follow-up assessment, participants had average decreased intake of red meat (3.148/6 vs. 2.685/6, p &lt; 0.001), and average increased intake of vegetables (4.484/6 vs. 5.044/6, p &lt; 0.001) and fruits (4.327/6 vs. 4.877/6, p &lt; 0.001), compared to their intake at pre-education assessment. Additionally, average change in beer (-0.252) and spirit (-0.905) consumption substantively decreased from pre-intervention to 6-month follow-up assessment. Conclusion: This community-based education showed significant effects in improving healthy dietary behaviors and reducing alcohol intake among community members through CBPR community engagement from the two metropolitan areas. Future efforts are needed to sustain the positive changes in modifiable lifestyle behaviors and liver cancer prevention in these medically underserved communities.
Citation Format: Tiffany Li, Wenyue Lu, Lin Zhu, Ellen Kim, Kerry Traub, Steven Zhu, Nathaly Rubio-Torio, Evelyn Gonzalez, Marilyn A. Fraser, Ming-Chin Yeh, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. A community-based liver cancer education initiative led to healthier dietary and alcohol use behaviors among racial/ethnic minority community members [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-161.
Abstract PO-196: Upregulation of bacterial and fungal pathogen sensing genes in preinvasive colorectal lesions in African Americans compared to Caucasian Americans
Authors: Guglietta Silvia , Fanning Lauren R. , Cousart Alexandria G. , Armeson Kent E. , Sun Zequn , Lewin David N. , Brazeal J Grant , Chung Dongjun , Alekseyenko Alexander V. , Wallace Kristin 
Published: January 2022

Abstract
Background: Colorectal cancer (CRC) incidence and mortality are higher for African Americans (AAs) than Caucasian Americans (CAs). Variation in tumor immune responses by race appears to be important for prognosis. However, few studies have compared immune gene expression in preinvasive lesions where prevention may be possible. Methods: The immune gene expression of 95 cases of colorectal adenomas (AA 47, CA 48) excised via sigmoidoscopy or colonoscopy with polypectomy between October 2012 and May 2016 was assessed using the NanoString nCounter platform using the immunology v2 panel (n=579 genes). Data were analyzed using a NanoStringDiff R package, implementing negative binomial regression models of gene expression as the dependent variable and race group (AA vs. CA) as the primary predictor variable. Models were adjusted for age, sex, location within the colon, histology, and degree of dysplasia. Results: In AAs vs. CAs, 24 immune genes were up-regulated, while 11 genes were down-regulated (for each gene, p&lt;0.01). Compared to CAs, genes overexpressed in AAs suggest more robust antibacterial and antifungal responses (e.g., IL17F, IL21, AIRE, IL1A, GATA3, MARCO, FCGR1A). Enhanced expression of terminal components of the complement pathway C8B and C9 further support an increased effector response in AAs. Additionally, genes related to wound healing (e.g., GP1BB, XCL1) were overexpressed in AAs. Genes associated with stimulation of cytotoxic responses (NCR1, HLADRB1), complement activation through lectin-related pathways (ITLN2, MBL2), and recruitment and function of innate immune cells (IL8 and IL6) had lower expression in AAs vs. CAs. Conclusion: Our results suggest that preinvasive neoplasms in AAs vs. CAs display a gene expression that is suggestive of heightened sensing of bacterial and fungal commensals, which may potentially inflame local tissues and support tumor progression. Understanding the molecular differences in early tumorigenesis between AAs vs. CAs may help inform prevention interventions to address racial disparities.
Citation Format: Silvia Guglietta, Lauren R. Fanning, Alexandria G. Cousart, Kent E. Armeson, Zequn Sun, David N. Lewin, J Grant Brazeal, Dongjun Chung, Alexander V. Alekseyenko, Kristin Wallace. Upregulation of bacterial and fungal pathogen sensing genes in preinvasive colorectal lesions in African Americans compared to Caucasian Americans [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-196.
Abstract PO-222: Reduced socioeconomic status disparity in colon cancer mortality in an insured population treated in an integrated healthcare system
Authors: Attaluri Vikram , Cooper Robert M. , Haque Reina , Patel Jay , Ryoo Joan J. , Wu David P. , Chung Joanie WL 
Published: January 2022

Abstract
Objectives: Lower socioeconomic status (SES), among other factors, presents a barrier to healthcare delivery and is associated with worse health outcomes. Integrated healthcare systems (IHS) in which barriers to care are minimized would be ideal settings to identify factors associated with mortality disparities. The aim of this study was to compare outcomes of colon cancer cases diagnosed at one of the largest IHS in California, Kaiser Permanente Southern California (KPSC), to other private insurance (OPI) to determine how SES influence differences in mortality. Methods: This retrospective cohort study included all insured adults in Southern California diagnosed with colon cancer between 2009 and 2014 using data from the California Cancer Registry (CCR). The main outcome was all-cause (overall) mortality, and subjects were followed through December 31, 2017. Person-year mortality rates were calculated for the two groups, KPSC and OPI. Multivariate adjusted hazard ratios were calculated for the association between SES and overall mortality within each group. Results: A total of 16,646 patients were diagnosed with colon cancer in Southern California, 4552 patients (27.3 %) within KPSC and 12,094 patients (72.3%) in OPI. 5937 deaths occurred during the follow-up period; 1428 (24.1%) deaths within KPSC, 4509 (75.9%) deaths in non-KPSC. Mortality rates per 1000 year follow-up with 95% confidence interval revealed a lower overall rate of 103.8 (98.5 – 109.3) in KPSC compared to 139.3 (135.2 – 143.4.) in OPI. Compared to the highest SES group, lower SES was not significantly associated with mortality in the KPSC population, even after adjusting for race/ethnicity and other factors (lowest SES HR 1.13 95% CI 0.93-1.38). However, in OPI patients, lower SES was significantly associated with higher HR with the greatest disparity in the lower-middle (HR 1.27 95% CI 1.15-1.40) and lowest (HR 1.26 95% CI 1.13-1.40) SES groups. Conclusions: Comparing mortality rates in an integrated health system such as KPSC to OPI hospitals revealed that lower SES was associated with worse outcomes within the OPI group. However, within KPSC no association was found between SES and overall mortality in patients with colon cancers. Systems that optimize care coordination for all patients may reduce disparities for the most at risk patients.
Citation Format: Vikram Attaluri, Robert M. Cooper, Reina Haque, Jay Patel, Joan J. Ryoo, David P. Wu, Joanie WL Chung. Reduced socioeconomic status disparity in colon cancer mortality in an insured population treated in an integrated healthcare system [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-222.