bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Value-centered Exploration of Data Privacy and Personalized Privacy Assistants
Authors: Carter Sarah E. 
Published: November 2022

AbstractIn the current post-GDPR landscape, privacy notices have become ever more prevalent on our phones and online. However, these notices are not well suited to their purpose of helping users make informed decisions. I suggest that instead of utilizing notice to elicit informed consent, we could repurpose privacy notices to create the space for more meaningful, value-centered user decisions. Value-centered privacy decisions, or those that accurately reflect who we are and what we value, encapsulate the intuitive role of personal values in data privacy decisions. To explore how we could design for such decisions, I utilize Suzy Killmister’s Four-Dimensional Theory of Autonomy (4DT) to operationalize value-centered privacy decisions. I then utilize 4DT to help design a system—called a value-centered privacy assistant (VcPA)—that could help create the space for value-centered data privacy decisions using privacy notices. Using this 4DT lens, I further assess the degree that an existing technology, personalized privacy assistants (PPAs), use notices in a manner that allows for value-centered decision-making. I lastly utilize insights from the PPA assessment to inform the design of a VcPA, concluding that a VcPA could utilize notices to assist users in value-centered app selection and in other data privacy decisions.
Predicting cyclone landfall using mutual information and dilated recurrent neural network
Authors: Mukherjee Abhijit , Mitra Pabitra 
Published: November 2022

Abstract
Cyclones are a severe storm system with a defined center, occurring in the tropical regions. Upon landfall, it causes massive damage to both lives and the economy. With the increase in frequency and intensity of tropical cyclones occurring over the years and growing coastal settlements, the study of cyclone landfall remains of paramount importance for disaster control and mitigation. Cyclones experience rapid changes, with various environmental factors modulating the trajectory and intensity. Thus predicting cyclone landfall demands a highly precise technique coupled with knowledge of environmental parameters. With the complexity and nonlinearity of the cyclone track data, determining parameters conducive for the landfall prediction of a cyclone remains crucial for precision and knowledge of the storm system. While numerous methods have been employed for detecting causal interactions among weather systems like Granger Causality and Transfer Entropy, each comes with its limitation and computational overhead. In this work, we investigate the where and when of a cyclone landfall by studying the influencing factors regulating the location and time of a cyclone landfall over the North Indian Ocean with mutual information (MI). We utilize dilated recurrent neural network with gated recurrent unit cells coupled with feature selection via MI criterion for predicting the cyclone landfall location and intensity between 12 and 36 training hours. The model efficacy is validated further on the landfall data of a recent devastating storm—Fani.
Judging reliability at wine and water competitions
Authors: Berg Elena C. , Mascha Michael , Capehart Kevin W. 
Published: November 2022

AbstractStudies suggest the inter-rater reliability of judges at wine competitions is higher than what would be expected by random chance, but lower than what is observed when experts in other fields make judgments specific to their expertise. To further contextualize the (un-) reliability of wine judging while also extending the study of fine water, we examine the inter-rater reliability of judges at an annual international competition for bottled waters. We find that the inter-rater reliability of water judging is generally better than chance and, at best, about the same as the inter-rater reliability of wine judging at some wine competitions. These results suggest that perceptible differences between fine waters exist but are less pronounced than those between fine wines and, also, that aesthetic standards with respect to fine waters exist but are currently less established than those for fine wines.
Working musically with care-experienced children and their families in the early years
Authors: David Humphrey Ryan 
Published: November 2022

AbstractLiving within state care can have detrimental effects on children’s development, as substantial research has proposed. Recognising how music-making may support children’s social, emotional and personal development, many cultural organisations have begun developing music projects that work specifically with care-experienced children. Although evaluation has detailed the various benefits these projects may have, there has been little research into the approaches employed by the facilitators who deliver these projects. With this in mind, this article examines a community music project that focused on foster family music-making. It explores the facilitators’ social pedagogical approach to music-making and the benefits participants report they have gained from the project, both to themselves and the children in their care.
Public and private protected areas can work together to facilitate the long-term persistence of mammals
Authors: Ivanova Ielyzaveta M , Cook Carly N 
Published: November 2022

SummaryThe conservation performance of protected areas (PAs) is typically measured according to whether species are likely to be present within PAs. However, to attain the goal of long-term conservation it is important to consider the performance of PAs in terms of their ability to support the persistence of the species they contain. We used the concept of minimum viable population (MVP) size to examine the potential for PAs within a large national PA network to support mammal species over the long term. By developing habitat models for each species and estimating the area required to support the MVP size for each species, we identified whether each PA had sufficient habitat to meet the species’ requirements. We found that as a whole the PA network is able to support at least one viable population for all species studied. However, the extent of protection offered to species by the PA network varies considerably, with many PAs not able to support viable populations of individual species on their own. By understanding the capacity of PAs to provide long-term protection to species, our findings can guide strategies to increase the resilience of PA networks as a whole, including by improving habitat quality within and connectivity between PAs.
Development and complications of nutritional deficiencies after bariatric surgery
Authors: Steenackers Nele , Van der Schueren Bart , Augustijns Patrick , Vanuytsel Tim , Matthys Christophe 
Published: November 2022

AbstractThe clinical effectiveness of bariatric surgery has encouraged the use of bariatric procedures for the treatment of morbid obesity and its comorbidities, with sleeve gastrectomy and Roux-en-Y gastric bypass being the most common procedures. Notwithstanding its success, bariatric procedures are recognised to predispose the development of nutritional deficiencies. A framework is proposed that provides clarity regarding the immediate role of diet, the gastrointestinal tract and the medical state of the patient in the development of nutritional deficiencies after bariatric surgery, while highlighting different enabling resources that may contribute. Untreated, these nutritional deficiencies can progress in the short term into haematological, muscular and neurological complications and in the long term into skeletal complications. In this review, we explore the development of nutritional deficiencies after bariatric surgery through a newly developed conceptual framework. An in-depth understanding will enable the optimisation of the post-operative follow-up, including detecting clinical signs of complications, screening for laboratory abnormalities and treating nutritional deficiencies.
Seismic Anisotropy Tomography and Mantle Dynamics of Central‐Eastern USA
Authors: Liang Xuran , Zhao Dapeng , Hua Yuanyuan , Xu Yi‐Gang 
Published: November 2022

AbstractWe present high‐resolution 3‐D tomographic models of isotropic P‐wave velocity (Vp), azimuthal anisotropy, and radial anisotropy down to 1,300 km depth beneath the central and eastern United States (CEUS), which are obtained by inverting a great number of local and teleseismic data and making a whole‐mantle correction to teleseismic travel‐time data recorded by the USArray. Trade‐offs between azimuthal and radial anisotropies occur due to the correlation between the azimuthal and incidence angles of seismic rays, but the use of uniform and crisscrossing rays can reduce the trade‐off effect. Our tomographic images reveal the North American Craton with layered anisotropy and strong anisotropies in the lower mantle related to the deeply subducted Farallon slab and passage of the Bermuda hotspot. In the upper mantle, low‐velocity anomalies with significant seismic anisotropy are revealed beneath three intraplate seismic zones in New Madrid, East Tennessee, and South Carolina, suggesting that hot and wet mantle upwelling occurs under the seismic zones, and the related fluids affect the earthquake generation. The most important dynamic processes in the mantle beneath the CEUS are the deep subduction of the Farallon plate and the passage of the Bermuda hotspot, which have caused strong structural heterogeneities, seismic anisotropy, as well as thermal anomalies and fluids that contributed to the formation of intraplate seismic zones in the CEUS.
Biological drivers of clinical phenotype in myelofibrosis
Authors: Mascarenhas John , Gleitz Hélène F. E. , Chifotides Helen T. , Harrison Claire N. , Verstovsek Srdan , Vannucchi Alessandro Maria , Rampal Raajit K. , Kiladjian Jean-Jacques , Vainchenker William , Hoffman Ronald , Schneider Rebekka K. , List Alan F. 
Published: November 2022

AbstractMyelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or cytopenic phenotype and the myeloproliferative phenotype. The cytopenic phenotype has a high prevalence in primary MF (PMF) and is characterized by low blood counts. The myeloproliferative phenotype is typically associated with secondary MF (SMF), mild anemia, minimal need for transfusion support, and normal to mild thrombocytopenia. Differences in somatic driver mutations and allelic burden, as well as the acquisition of non-driver mutations further influences these phenotypic differences, prognosis, and response to therapies such as JAK2 inhibitors. The outcome of patients with the cytopenic phenotype are comparatively worse and frequently pose a challenge to treat given the inherent exacerbation of cytopenias. Recent data indicate that an innate immune deregulated state that hinges on the myddosome-IRAK-NFκB axis favors the cytopenic myelofibrosis phenotype and offers opportunity for novel treatment approaches. We will review the biological and clinical features of the MF disease spectrum and associated treatment considerations.
Enhancement of THz generation in LiNbO3 waveguides via multi-bounce velocity matching
Authors: Dastrup Blake S. , Sung Eric R. , Wulf Frank , Saraceno Clara , Nelson Keith A. 
Published: November 2022

AbstractTo realize the full promise of terahertz polaritonics (waveguide-based terahertz field generation, interaction, and readout) as a viable spectroscopy platform, much stronger terahertz fields are needed to enable nonlinear and even robust linear terahertz measurements. We use a novel geometric approach in which the optical pump is totally internally reflected to increase the distance over which optical rectification occurs. Velocity matching is achieved by tuning the angle of internal reflection. By doing this, we are able to enhance terahertz spectral amplitude by over 10x compared to conventional single-pass terahertz generation. An analysis of the depletion mechanisms reveals that 3-photon absorption and divergence of the pump beam are the primary limiters of further enhancement. This level of enhancement is promising for enabling routine spectroscopic measurements in an integrated fashion and is made more encouraging by the prospect of further enhancement by using longer pump wavelengths.
BSP implementation of the 2017 classification of periodontal diseases: a practice retrospective
Authors: Claydon Nicholas , Thomas Dave W. , Adams Robert J. , West Nicola , Hodge Shaun 
Published: November 2022

AbstractIntroduction The new world classification of periodontal diseases and conditions was developed in 2017. The British Society of Periodontology and Implant Dentistry (BSP) implemented the classification in a series of papers published in the British Dental Journal in January 2019.Aims and objectives This study aimed to investigate if the BSP implementation was workable in general dental practice and to reveal if any lessons were learnt from its regular use two years following its release.Materials and methods This was a cross-sectional, retrospective, non-intervention analysis of a patient population (n = 891) drawn from a complete list of a private dental surgeon. Diagnostic and demographic data were drawn from the patient records, collated and analysed using SPSS Statistics v26.Results Diagnoses derived from the new classification were identified for 92% of subjects, indicating a high level of implementation. In total, 20.9% of subjects were diagnosed with periodontitis, and of these, 57% were unstable, 39% stable and 4% in remission. The mean bleeding on probing score across the cohort was 7.7%. Moreover, 76% of the non-periodontitis patients were diagnosed with 'clinical gingival health', 23% with localised gingivitis and 1% with generalised gingivitis.Conclusion The new classification has been found to be readily implemented in a general practice setting. Use of the new classification allows for close monitoring of periodontal status, and as a result, close monitoring of the effectiveness of pathways of care.
Additional consensus recommendations for conducting complex innovative trials of oncology agents: a post-pandemic perspective
Authors: Blagden Sarah P. , Yu Ly-Mee , Ellis Stephanie , Hughes Helen , Shaaban Abeer , Fennelly-Barnwell Jonathan , Lythgoe Mark P. , Cooper Alison M. , Maignen Francois M. , Buckland Sean W. , Kearns Pamela R. , Brown Louise C. ,   Experimental Cancer Medicine Centres (ECMC) CID trials working group
Published: November 2022

AbstractIn our 2020 consensus paper, we devised ten recommendations for conducting Complex Innovative Design (CID) trials to evaluate cancer drugs. Within weeks of its publication, the UK was hit by the first wave of the SARS-CoV-2 pandemic. Large CID trials were prioritised to compare the efficacy of new and repurposed COVID-19 treatments and inform regulatory decisions. The unusual circumstances of the pandemic meant studies such as RECOVERY were opened almost immediately and recruited record numbers of participants. However, trial teams were required to make concessions and adaptations to these studies to ensure recruitment was rapid and broad. As these are relevant to cancer trials that enrol patients with similar risk factors, we have added three new recommendations to our original ten: employing pragmatism such as using focused information sheets and collection of only the most relevant data; minimising negative environmental impacts with paperless systems; and using direct-to-patient communication methods to improve uptake. These recommendations can be applied to all oncology CID trials to improve their inclusivity, uptake and efficiency. Above all, the success of CID studies during the COVID-19 pandemic underscores their efficacy as tools for rapid treatment evaluation.
Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation
Authors: Leyden Genevieve M. , Greenwood Michael P. , Gaborieau Valérie , Han Younghun , Amos Christopher I. , Brennan Paul , Murphy David , Davey Smith George , Richardson Tom G. 
Published: November 2022

Abstract
Background
Body mass index (BMI) is known to influence the risk of various site-specific cancers, however, dissecting which subcomponents of this heterogenous risk factor are predominantly responsible for driving disease effects has proven difficult to establish. We have leveraged tissue-specific gene expression to separate the effects of distinct phenotypes underlying BMI on the risk of seven site-specific cancers.

Methods
SNP-exposure estimates were weighted in a multivariable Mendelian randomisation analysis by their evidence for colocalization with subcutaneous adipose- and brain-tissue-derived gene expression using a recently developed methodology.

Results
Our results provide evidence that brain-tissue-derived BMI variants are predominantly responsible for driving the genetically predicted effect of BMI on lung cancer (OR: 1.17; 95% CI: 1.01–1.36; P = 0.03). Similar findings were identified when analysing cigarettes per day as an outcome (Beta = 0.44; 95% CI: 0.26–0.61; P = 1.62 × 10−6), highlighting a possible shared aetiology or mediator effect between brain-tissue BMI, smoking and lung cancer. Our results additionally suggest that adipose-tissue-derived BMI variants may predominantly drive the effect of BMI and increased risk for endometrial cancer (OR: 1.71; 95% CI: 1.07–2.74; P = 0.02), highlighting a putatively important role in the aetiology of endometrial cancer.

Conclusions
The study provides valuable insight into the divergent underlying pathways between BMI and the risk of site-specific cancers.
Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells
Authors: Alkasalias Twana , Zhang Juan , Madapura Harsha , Dalarun Basile , Reina Oscar Bedoya , Lewensohn Rolf , Viktorsson Kristina , Salihi Abbas , Darekar Suhas , Laín Sonia 
Published: November 2022

AbstractHighly specific and potent inhibitors of dihydroorotate dehydrogenase (DHODH), an essential enzyme of the de novo pyrimidine ribonucleotide synthesis pathway, are in clinical trials for autoimmune diseases, viral infections and cancer. However, because DHODH inhibitors (DHODHi) are immunosuppressants they may reduce the anticancer activity of the immune system. Therefore, there may be a need to improve the therapeutic index of DHODHi in cancer patients. The aim of this study was to find strategies to protect activated T cells from DHODHi and to identify cancer types hypersensitive to these inhibitors. First, we observed that like uridine supplementation, adding cytidine to the culture medium protects T cells from DHODH blockage. Next, we identified tumor types with altered expression of pyrimidine ribonucleotide synthesis enzymes. In this regard, we detected that the expression of cytidine deaminase (CDA), which converts cytidine into uridine, is low in an important proportion of cancer cell lines and consistently low in neuroblastoma samples and in cell lines from neuroblastoma and small cell lung carcinoma. This suggested that in the presence of a DHODHi, an excess of cytidine would be deleterious for low CDA expressing cancer cell lines. We show that this was the case (as could be seen almost immediately after treatment) when cells were cultured with fetal bovine serum but, was significantly less evident when cultures contained human serum. One interesting feature of CDA is that aside from acting intracellularly, it is also present in human plasma/serum. Altogether, experiments using recombinant CDA, human serum, pharmacologic inhibition of CDA and T cell/cancer cell co-cultures suggest that the therapeutic index of DHODHi could be improved by selecting patients with low-CDA expressing cancers in combination with strategies to increase cytidine or the cytidine/uridine ratio in the extracellular environment. Collectively, this proof-of-principle study warrants the discovery of agents to deplete extracellular CDA.
Growth of nonexudative macular neovascularization in age-related macular degeneration: an indicator of biological lesion activity
Authors: Wang Yusong , Sun Junran , Wu Jiali , Jia Huixun , Feng Jingyang , Chen Jieqiong , Yan Quan , Huang Peirong , Wang Fenghua , Bo Qiyu , Sun Xiaodong 
Published: November 2022

Abstract
Purpose
To investigate the growth of nonexudative macular neovascularization (MNV) in age-related macular degeneration (AMD) using swept-source optical coherence tomography angiography (SS-OCTA).

Methods
Patients with treatment-naïve nonexudative AMD in one eye and exudative AMD in the fellow eye who underwent SS-OCTA imaging for at least 12 months were retrospectively reviewed. The MNV area measurement was quantified in eyes with treatment-naïve nonexudative MNV using ImageJ for analysing the correlation between MNV growth and the onset of exudation, as well as evaluating the consistency of the MNV growth rate during the subclinical and exudative stages. Kaplan-Meier survival analysis and logistic regression analyses were used.

Results
In total, 45 eyes with treatment-naïve nonexudative AMD from 45 patients were enrolled. Treatment-naïve nonexudative MNV was identified in 21 eyes (46.67%) at baseline. The development of exudative findings was noted in eight eyes (17.78%), including six eyes with previously noted nonexudative MNV. Eyes with growing MNV (increase in area ≥50% within 12 months) had an increased risk of exudation and developed exudation earlier than eyes with stable MNV (13.60 [6.43–20.77] months versus 31.11 [26.61–35.62] months, P < 0.0001, Log-rank test). Consistent growth pattern of MNV lesions was further identified in eyes with growing MNV during anti-VEGF treatment.

Conclusion
SS-OCTA allows to qualitatively and quantitatively evaluate nonexudative MNV in AMD patients. Growing MNV involved higher probabilities and a faster onset of exudation compared to stable MNV. Identifying the growth of MNV on OCTA might be helpful for establishing treatment strategies and follow-up planning.
Motor cortex excitability is reduced during freezing of upper limb movement in Parkinson’s disease
Authors: Topka Marlene , Schneider Marlieke , Zrenner Christoph , Belardinelli Paolo , Ziemann Ulf , Weiss Daniel 
Published: November 2022

AbstractWhilst involvement of the motor cortex in the phenomenon of freezing in Parkinson’s disease has been previously suggested, few empiric studies have been conducted to date. We investigated motor cortex (M1) excitability in eleven right-handed Parkinson’s disease patients (aged 69.7 ± 9.6 years, disease duration 11.2 ± 3.9 years, akinesia-rigidity type) with verified gait freezing using a single-pulse transcranial magnetic stimulation (TMS) repetitive finger tapping paradigm. We delivered single TMS pulses at 120% of the active motor threshold at the ‘ascending (contraction)’ and ‘descending (relaxation)’ slope of the tap cycle during i) regular tapping, ii) the transition period of the three taps prior to a freeze and iii) during freezing of upper limb movement. M1 excitability was modulated along the tap cycle with greater motor evoked potentials (MEPs) during ‘ascending’ than ‘descending’. Furthermore, MEPs during the ‘ascending’ phase of regular tapping, but not during the transition period, were greater compared to the MEPs recorded throughout a freeze. Neither force nor EMG activity 10–110 s before the stimulus predicted MEP size. This piloting study suggests that M1 excitability is reduced during freezing and the transition period preceding a freeze. This supports that M1 excitability is critical to freezing in Parkinson’s disease.