bluuebunny/crossref_metadata_2025_split huggingface dataset:
Love in the Time of Covid
Authors: Schroeder Jeanne L. 
Published: November 2022

A striking aspect of the current American cultural divide is divergent attitudes towards expertise, generally, and masking and vaccination to mitigate the Covid-19 pandemic, specifically. Liberal pundits profess shock that Red State America won’t just ‘trust the science’. On the right, politicians and television personalities reject mandates in the name of ‘freedom’. Lacanian discourse theory gives insight into this. The rejection of expertise is an example of an ‘hysteric discourse’ challenging a ‘university discourse’: the regime of experts. An hysteric discourse is a critique of rules imposed by experts by the subjects-subjected-to them. Hysteria can lead, in turn, to a ‘master discourse’ which rules through authority alone, without justification by external norms. I show how this helps explain the personality cult of love for Donald Trump. In addition, I suggest how these three discourses relate to law and jurisprudence.
Cemas dan Berat Badan Ibu Hamil Terhadap Kejadian Emesis Gravidarum
Authors: Mudlikah Siti , Munisah Munisah , Yunita Nourma 
Published: November 2022

Perubahan psikologis proses hamil meningkatkan cemas yang merangsang emesis gravidarum dan berdampak penurunan berat badan. Tujuan penelitian untuk mengetahui pengaruh cemas, berat badan terhadap emesis gravidarum. Metode penelitian Analitik observasional pendekatan cross sectional, Populasi 30 ibu hamil trimester satu dengan teknik total sampling. Data cemas diambil menggunakan kuesioner skala HRS-A. Data Berat badan menggunakan lembar observasi ceklis. Data emesis gravidarum didapatkan dari kuesioner. Hasil penelitian diketahui bahwa ibu hamil cemas terjadi emesis gravidarum sebesar 94.4% dan tidak cemas sebesar 5,6%, signifikansi 0.017< 0,05, berarti ada pengaruh cemas terhadap emesis gravidarum. Jumlah Ibu hamil dengan emesis gravidarum yang mengalami kenaikan berat badan sebesar 94,4% dan jumlah yang tidak naik sebesar 5,6%. Sedangkan jumlah ibu hamil tidak emesis gravidarum dan tidak ada kenaikan berat badan sebesar 58.3% dan terjadi berat badan naik sebesar 41,7%, siqnifikansi sebesar 0.008 < 0,05, berarti ada pengaruh kenaikan berat badan terhadap emesis gravidarum. Kesimpulan, cemas dan berat badan mempengaruhi emesis gravidarum. Cemas yang meningkat dan berat badan makin turun merangsang emesis gravidarum. Diharapkan ada pendampingan terhadap ibu hamil dan pemantauan berat badan secara berkala
Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity
Authors: Safaei Zahra , Thompson Gary L. 
Published: November 2022

Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes. We demonstrate a µsPEF bioeffect on nucleocytoplasmic import and export of enzymes that regulate genetic expression, histone deacetylases (HDAC) -4 and -5. Their μsPEF-induced nucleocytoplasmic transport depends on presence and absence of extracellular calcium ions (Ca2+) for both MCF7 and CHO-K1 cells. Exposure to 1, 10, 30 and 50 consecutive square wave pulses at 1 Hz and of 100 µs duration with 1.45 kV/cm magnitude leads to translocation of endogenous HDAC4 and HDAC5. We posit that by eliciting a rise in intracellular Ca2+ concentration, a signaling pathway involving kinases, such as Ca2+/CaM-dependent protein kinase II (CaMKII), is activated. This cascade causes nuclear export and import of HDAC4 and HDAC5. The potential of µsPEF exposures to control nucleocytoplasmic transport unlocks future opportunities in epigenetic modification.
Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study
Authors: Griffoni Cristiana , Tedesco Giuseppe , Canella Valentina , Nataloni Angelo , Zerbi Alberto , Tosini Giovanni , Gasbarrini Alessandro , Barbanti-Brodano Giovanni 
Published: November 2022

Background: Iliac crest bone graft (ICBG) is considered the gold standard for spine surgical procedures to achieve a successful fusion due to its known osteoinductive and osteoconductive properties. However, complications related to harvesting procedure and donor site morbidity have been largely reported in the literature, favoring the development of a wide range of alternative products to be used as bone graft extenders or substitutes for spine fusion. Among all, ceramic-based biomaterials have been widely studied and employed in the last years as bone graft substitutes.Methods: We report here the results of a prospective pilot study aimed to evaluating the grade of ossification obtained by the use of an Mg-doped hydroxyapatite (HA) product to achieve postero-lateral fusion in degenerative spine diseases.Results: Results show a successful degree of fusion of about 62% at the 12-month follow-up and an improvement of quality of life and health status following surgery, as evaluated by clinical scores (ODI, VAS, and EQ-5L). No adverse events related to the material were reported.Conclusion: The present pilot study shows the effectiveness and the safety profile of an Mg-doped HA bone graft substitute used to achieve postero-lateral fusion in the treatment of degenerative spine diseases, laying down the basis for further larger clinical investigations.
Image-guided stent-directed irreversible electroporation for circumferential ablation in the rat esophagus
Authors: Kim Song Hee , Jeong Seung , Kang Jeon Min , Park Yubeen , Ryu Dae Sung , Won Dong-Sung , Kim Ji Won , Zeng Chu Hui , Kim Hyung-Sik , Kim Hong Bae , Lee Sang Soo , Park Jung-Hoon 
Published: November 2022

Background: Irreversible electroporation (IRE) has been investigated in the alimentary tract; however, the lack of dedicated electrodes and insufficient tissue responses made its application limited. The aim of this study was to investigate the efficacy and safety of image-guided stent-directed IRE in the rat esophagus.Methods: The bipolar self-expandable electrode (SE) was developed using the braiding technique. A finite element analysis was performed to validate optimal electrical field strength for the rat esophagus. A total of 40 out of 50 rats received stent-directed IRE and were sacrificed at 10 h, 3 days, 7 days, and 28 days of 10 each. The remaining ten rats underwent a sham procedure. The outcomes of stent-directed IRE were assessed by esophagography and histological responses.Results: Stent-directed IRE was technically successful in all rats with mild muscle contraction. The heart rate dropped immediately and gradually recovered at 180 s. TUNEL and caspase-3 with submucosal thickness significantly increased at 10 h and Day 3 compared with those of the sham control (all p &lt; 0.001). The thickness of epithelial layers with collagen deposition significantly decreased at 10 h and Day 3 (all p &lt; 0.001), however, increased at Day 7 compared with that of the sham control (all p &lt; 0.05). The Ki67-positive deposition significantly increased at Day 3 and 7 compared with that of the sham control (all p &lt; 0.001). All variables were similar to those of the sham control at Day 28.Conclusion: Image-guided stent-directed IRE was effective and safe in the rat esophagus. It seems to have effectively and evenly induced cell death and gradually recovered with cellular regeneration.
Postoperative central venous pressure is associated with acute kidney injury in patients undergoing coronary artery bypass grafting
Authors: Li Jiale , Wang Ruiling , Wan Jun , Zhu Peng , Xiao Zezhou , Wang Xiaowu , Zheng Shaoyi 
Published: November 2022

ObjectiveThe present study aimed to investigate the association of postoperative central venous pressure (CVP) with acute kidney injury (AKI) and mortality in patients undergoing coronary artery bypass grafting (CABG).MethodPatients who underwent CABG in the MIMIC-III database were included and divided into two groups according to the optimal cutoff value of CVP for postoperative AKI determined by the receiver operating characteristic (ROC) curves. The association of CVP with AKI and mortality was determined by multivariate regression models. A 1:1 propensity score matching (PSM) was performed to balance the influence of potential confounding factors.ResultsA total of 3,564 patients were included and divided into High CVP group (CVP ≥ 10.9 mmHg) and Low CVP group (CVP &lt; 10.9 mmHg) according to the ROC analysis. Patients in High CVP group presented with higher AKI incidence (420 (28.2%) vs. 349 (16.8), p &lt; 0.001), in-hospital mortality (28 (1.9%) vs. 6 (0.3%), p &lt; 0.001) and 4-year mortality (149 (15.8%) vs. 162 (11.1%), p = 0.001). Multivariate regression model showed that CVP was an independent risk factor for the postoperative AKI (OR: 1.071 (1.035, 1.109), p &lt; 0.001), in-hospital mortality (OR: 1.187 (1.026, 1.373), p = 0.021) and 4-year mortality (HR: 1.049 (1.003, 1.096), p = 0.035). A CVP above 10.9 mmHg was significantly associated with about 50% higher risk of AKI (OR: 1.499 (1.231, 1.824), p &lt; 0.001). After PSM, 1004 pairs of score-matched patients were generated. The multivariate logistic model showed that patients with CVP ≥ 10.9 mmHg had a significantly higher risk of AKI (OR: 1.600 (1.268, 2.018), p &lt; 0.001) in the PSM subset. However, CVP, as a continuous or a dichotomic variable, was not independently associated with in-hospital mortality (OR: 1.202 (0.882, 1.637), p = 0.244; OR: 2.636 (0.399, 17.410), p = 0.314) and 4-year mortality (HR: 1.030 (0.974, 1.090), p = 0.297; HR: 1.262 (0.911, 1.749), p = 0.162) in the PSM dataset.ConclusionA mean CVP ≥ 10.9 mmHg within the first 24 h after CABG was independently associated with a higher risk of postoperative AKI.
Electrophysiological characteristics of epicardial breakthrough during catheter ablation of perimitral atrial flutter
Authors: Chhay Chheng , Hsu Chu-Yu , Chang Shih-Lin , Lin Yenn-Jiang , Lo Li-Wei , Hu Yu-Feng , Chung Fa-Po , Chang Ting-Yung , Lin Chin-Yu , Hung Yuan , Liu Chih-Min , Kuo Ling , Liu Shin-Huei , Ahli Lia , Kuo Ming-Jen , Cheng Wen-Han , Kao Pei-Heng , Chen Wei-Tso , Khac Thien Chuong-Nguyen , Lin Wei-Shiang , Chen Shih-Ann 
Published: November 2022

IntroductionUnsuccessful endocardial ablation for perimitral atrial flutter (AFL) could be attributed by the epicardial bridging.ObjectiveThis study aimed to investigate the electrophysiological characteristics of epicardial breakthrough during catheter ablation of perimitral AFL.Materials and methodsThis retrospective study recruited 40 patients who received successful catheter ablation of perimitral AFL from January 2016 to June 2021. The patients were divided into two groups: group 1 (n = 18) successful endocardial ablation, and group 2 (n = 22) successful epicardial ablation following unsuccessful endocardial ablation owing to incomplete mitral block or unachievable termination AFL. The local electrogram (EGM) interval of coronary sinus (CS) duration perimitral AFL was measured before catheter ablation.ResultsThere was no significant difference in the baseline characteristics between the two groups. In group 2, 60% of successful epicardial ablation was performed in intra-CS ablation and 40% in VOM ethanol infusion. Group 2 patients had a longer EGM interval of distal CS than that in group 1 (CS1-2: 64.2 17.5 vs. 42.4 0.09 ms, P = 0.008, CS3-4: 57.13 19.4 vs. 43.8 7.5 ms; P = 0.001). The conduction velocity at successful site was slower in group 2 compared to group 1 (0.18 0.05 vs. 0.75 0.19 m/s, P = 0.040). In the multivariate analysis, distal EGM interval (CS1-2) was identified as independent predictor of the need of epicardial ablation with the optimal cutoff of 49 ms.ConclusionLonger EGM interval in distal CS during perimitral AFL was observed in perimitral AFL patients with epicardial breakthrough following endocardial-failed ablation, which may be associated with the need of epicardial ablation.
Cardiac magnetic resonance imaging parameters show association between myocardial abnormalities and severity of chronic kidney disease
Authors: Jia Xi , Han Xiaoyu , Wang Yuqin , He Fangfang , Zhou Xiaoyue , Zheng Yuting , Guo Yingkun , Xu Rong , Liu Jia , Li Yumin , Gu Jin , Cao Yukun , Zhang Chun , Shi Heshui 
Published: November 2022

BackgroundChronic kidney disease patients have increased risk of cardiovascular abnormalities. This study investigated the relationship between cardiovascular abnormalities and the severity of chronic kidney disease using cardiac magnetic resonance imaging.MethodsWe enrolled 84 participants with various stages of chronic kidney disease (group I: stages 1–3, n = 23; group II: stages 4–5, n = 20; group III: hemodialysis patients, n = 41) and 32 healthy subjects. The demographics and biochemical parameters of the study subjects were evaluated. All subjects underwent non-contrast cardiac magnetic resonance scans. Myocardial strain, native T1, and T2 values were calculated from the scanning results. Analysis of covariance was used to compare the imaging parameters between group I-III and the controls.ResultsThe left ventricular ejection fraction (49 vs. 56%, p = 0.021), global radial strain (29 vs. 37, p = 0.019) and global circumferential strain (-17.4 vs. −20.6, p &lt; 0.001) were significantly worse in group III patients compared with the controls. Furthermore, the global longitudinal strain had a significant decline in group II and III patients compared with the controls (-13.7 and −12.9 vs. −16.2, p &lt; 0.05). Compared with the controls, the native T1 values were significantly higher in group II and III patients (1,041 ± 7 and 1,053 ± 6 vs. 1,009 ± 6, p &lt; 0.05), and T2 values were obviously higher in group I-III patients (49.9 ± 0.6 and 53.2 ± 0.7 and 50.1 ± 0.5 vs. 46.6 ± 0.5, p &lt; 0.001). The advanced chronic kidney disease stage showed significant positive correlation with global radial strain (r = 0.436, p &lt; 0.001), global circumferential strain (r = 0.386, p &lt; 0.001), native T1 (r = 0.5, p &lt; 0.001) and T2 (r = 0.467, p &lt; 0.001) values. In comparison with the group II patients, hemodialysis patients showed significantly lower T2 values (53.2 ± 0.7 vs. 50.1 ± 0.5, p = 0.002), but no significant difference in T1 values (1,041 ± 7 vs. 1,053 ± 6).ConclusionsOur study showed that myocardial strain, native T1, and T2 values progressively got worse with advancing chronic kidney disease stage. The increased T1 values and decreased T2 values of hemodialysis patients might be due to increasing myocardial fibrosis but with reduction in oedema following effective fluid management.Trial registration numberChiCTR2100053561 (http://www.chictr.org.cn/edit.aspx?pid=139737&amp;htm=4).
Relationship between obstructive sleep apnea-hypopnea syndrome and osteoporosis adults: A systematic review and meta-analysis
Authors: Wang Chaoyu , Zhang Zhiping , Zheng Zhenzhen , Chen Xiaojuan , Zhang Yu , Li Chunhe , Chen Huimin , Liao Huizhao , Zhu Jinru , Lin Junyan , Liang Hongwei , Yu Qiuying , Chen Riken , Liang Jinhua 
Published: November 2022

ObjectiveThis study is undertaken to explore the relationship between obstructive sleep apnea-hypopnea syndrome (OSAHS) and osteoporosis, including the relationship between OSAHS and osteoporosis incidence, lumbar spine bone mineral density (BMD), and lumbar spine T-score.MethodCochrane Library, PubMed, Embase, Web of Science, and other databases are searched from their establishment to April 2022. Literature published in 4 databases on the correlation between OSAHS and osteoporosis,lumbar spine BMD,lumbar spine T-score is collected. Review Manager 5.4 software is used for meta-analysis.ResultsA total of 15 articles are selected, including 113082 subjects. Compared with the control group, the OSAHS group has a higher incidence of osteoporosis (OR = 2.03, 95% CI: 1.26~3.27, Z = 2.90, P = 0.004), the lumbar spine BMD is significantly lower (MD = -0.05, 95% CI: -0.08~-0.02, Z = 3.07, P = 0.002), and the lumbar spine T-score is significantly decreased (MD = -0.47, 95% CI: -0.79~-0.14, Z = 2.83, P = 0. 005).ConclusionCompared with the control group, the OSAHS group has a higher incidence of osteoporosis and decreased lumbar spine BMD and T-score. In order to reduce the risk of osteoporosis, attention should be paid to the treatment and management of adult OSAHS, and active sleep intervention should be carried out.
Mendelian randomization study supports the causal association between serum cystatin C and risk of diabetic nephropathy
Authors: Feng Baiyu , Lu Yu , Ye Lin , Yin Lijun , Zhou Yingjun , Chen Anqun 
Published: November 2022

AimsCystatin C, an inhibitor of cysteine protease, has been used as a biomarker for estimating glomerular filtration rate. However, the causal relation between cystatin C and diabetic nephropathy remains uncertain.MethodsWe assessed the causal effect of cystatin C together with other five serum biomarkers including KIM-1, GDF-15, TBIL, uric acid, and Scr on diabetic nephropathy by Mendelian randomization (MR) analysis. 234 genetic variants were selected as instrumental variables to evaluate the causal effect of cystatin C (NGWAS=361194) on diabetic nephropathy (Ncase/Ncontrol up to 3283/210463). Multivariable MR (MVMR) was performed to assess the stability of cystatin C’s causal relationship. Two-step MR was used to assess the mediation effect of BMI and SBP.ResultsAmong the six serum biomarkers, only cystatin C causally associated with diabetic nephropathy (IVW OR: 1.36, 95%CI [1.15, 1.61]). After adjusting for the potential confounders BMI and SBP, cystatin C maintained its causal effect on the DN (OR: 1.17, 95%CI [1.02, 1.33]), which means that the risk of DN increased by 17% with an approximate 1 standard deviation (SD) increment of serum cystatin C level. Two-step MR results indicated that BMI might mediate the causal effect of cystatin C on diabetic nephropathy.InterpretationOur findings discovered that cystatin C was a risk factor for diabetic nephropathy independent of BMI and SBP in diabetes mellitus patients. Future research is required to illustrate the underlying mechanism and prove targeting circulating cystatin C could be a potential therapy method.
Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function
Authors: Zhou Wan , Li Jie , Yuan Xiaojing , Wang Wei , Zhou Huanran , Zhang Haoqiang , Ye Shandong 
Published: November 2022

ObjectiveThis study aims to investigate the effect of single urine C peptide/creatinine (UCPCR) in assessing the islet β Cell function of type 2 diabetes mellitus (T2DM) patients with different renal function.MethodsA total of 85 T2DM patients were recruited in this study, all the patients were assigned to one group with estimated glomerular filtration rate (eGFR)≤60 ml·min-1·1.73 m-2 and another group complicated with eGFR&gt;60 ml·min-1·1.73 m-2. Serum creatinine, urine creatinine, serum fasting C-peptide (FCP), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1C) and 24-hour urinary C-peptide (24hUCP) were measured. The modified homeostasis model assessment-islet β cell function [HOMA-islet (CP-DM)], the modified homeostasis model assessment-insulin resistance [HOMA-IR(CP)] and UCPCR were calculated.ResultsWhen compared with group eGFR ≤60 ml·min-1·1.73 m-2, the levels of UCPCR, FCP, the modified HOMA-IR(CP) and HOMA-islet (CP-DM) were promoted and the concentrations of HbA1C, FPG, creatinine were decreased in the patients of eGFR&gt;60 ml·min-1·1.73 m-2 (P&lt;0.05); FCP was uncorrelated with 24hUCP while associated with UCPCR in the patients of eGFR ≤ 60 ml·min-1·1.73 m-2; UCPCR was positively correlated with FCP and HOMA-IR(CP) in the T2DM patients with different levels of renal function; the cut-off (UCPCR ≤ 1.13 nmol/g) had 88.37% sensitivity and 95.24% specificity [95% confidence interval (CI):0.919-0.997] for identifying severe insulin deficiency in T2DM patients[area under the curve (AUC) 0.978].ConclusionUCPCR can be used to evaluate islets β Cell function in T2DM patients with different renal function status.
Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats
Authors: Li Xiang , Wu Kenan , Dong Qinzuo , Chen Hongxi , Li Chunyan , Ren Zeqin , Liu Fan , Yue Xianwu , Xia Chunlin , Wang Yuanfeng , Luo Yingjing , Li Li , Zhao Rong , Wang Zuhong , Qin Dongdong 
Published: November 2022

BackgroundAcupuncture is a widely practiced, convenient, and safe treatment modality within complementary and integrative medicine. Increasing studies have revealed the efficacy of acupuncture for the treatment of osteoporosis in both human and non-human subjects. The aim of the present study was to assess the improvement of osteoporosis after overall adjustment acupuncture (OA) as well as its endocrine-modulating effect in an ovariectomized rat model.MethodsIn total, 32 female Sprague–Dawley (SD) rats were randomly divided into the sham, model, ovariectomy+estrogen (OVX+E), and OVX+OA (OVX+A) groups with eight rats in each group. The postmenopausal osteoporosis (PMOP) rat model was induced by bilateral ovariectomy. At 12 weeks after surgery, rats in the OVX+E group received estradiol (0.2 mg/kg/i.g./qod) for 12 weeks, and rats in the OVX+A group were treated with acupuncture at Zusanli (ST36), Shenshu (BL23), and Dazhu (BL11) points (qod) for 12 weeks. At the end of the treatment, all rats were sacrificed, and the body weight, uterus index, bone mineral density (BMD), bone mineral content (BMC), bone trabeculae structural parameters, femoral biomechanical properties, femoral histomorphology, and several hormone levels were examined.ResultsIn OVX rats, OA abrogated the body weight gain and improved osteoporosis in terms of BMD, BMC, bone trabeculae structural parameters, bone strength, and bone tissue histomorphology. Moreover, OA modulated the serum levels of estradiol, corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (CORT).ConclusionsOA improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats.