bluuebunny/crossref_metadata_2025_split huggingface dataset:
The origin and population genetics of wolves in the north Hungarian mountains
Authors: Fehér Péter , Frank Krisztián , Gombkötő Péter , Rigg Robin , Bedő Péter , Újváry Dóra , Stéger Viktor , Szemethy László 
Published: July 2022

AbstractThe grey wolf (Canis lupus) is one of the most challenging species to conserve in our modern and crowded world. Due to various factors, most European wolf populations are currently growing. In Hungary, numbers have increased since the 2000s. Although spontaneous recolonisation from Slovakia is considered to be the most likely mechanism by the majority of experts, some stakeholders claim that hand-reared individuals have been released. To determine the origin of wolves in northern Hungary, we analysed samples of free-ranging wolves collected in Slovakia and Hungary as well as samples from wolves in private enclosures in the region. We also included reference samples from domestic dogs. All samples were genotyped at 14 canine autosomal tetranucleotide microsatellite loci (STR) and analysed using multivariate, Bayesian methods. Hungarian wolf samples were also analysed using kinship methods. In the free-ranging wolf samples, all loci were polymorphic with 3–12 alleles. The overall observed (Ho) and unbiased expected (uHE) heterozygosities were 0.60–0.66 and 0.69–0.71, respectively. Parental and sibling relationships were also found among Hungarian individuals: three generations of a pack in the Bükk Mountains were identified. Samples from free-ranging wolves clustered separately from those of captive wolves and dogs. However, genetic similarities were found between Slovakian and Hungarian wolf samples. Our analyses indicate a Slovakian origin of the sampled Hungarian wolves, and we found no evidence that individuals originating in captivity have played any role in the recolonisation process. Kinship relationships and moderate genetic diversity suggest that there is ongoing gene flow across the Slovakian–Hungarian border.
MD simulation estimation of saturation pressure and vapor-liquid equilibrium for binary blends of HFO-1234yf and HFO-1123
Authors: Alam Md. Sarwar , Jeong Ji Hwan 
Published: July 2022

AbstractSaturation pressure and vapor-liquid equilibrium data of low GWP hydrofluoroolefin compound HFO-1234yf (2,3,3,3-tetrafluoropropene) and its binary blends with HFO-1123 (1,1,2-trifluoroethene) were estimated using molecular dynamics (MD) simulation with the aid of COMPASS force field from 214.15 K to 330.15 K. The maximum absolute deviations of present saturated vapor pressure data from published experimental results were 0.03% for HFO-1123 system and 0.017% for HFO-1234yf system. These models were used to estimate the saturated vapor pressure for six different mixtures of HFO-1234yf and HFO-1123. The saturated liquid and vapor densities, the vapor-liquid coexistence curve (VLCC), and the critical points of the blended refrigerants with various molecular mass fractions were predicted using MD simulations and Gibbs ensemble Monte Carlo (GEMC) simulations. The critical points of HFO-1234yf and HFO-1123 matched well with published data.
Female Sexual Dysfunction Resources: Women and Healthcare Providers Need More Options
Authors: Dubinskaya A , Heard J , Choi E , Cohen T , Anger J , Eilber K , Scott V 
Published: July 2022

ABSTRACT

Introduction
Female sexual dysfunction (FSD) is an orphaned field due to numerous barriers faced by both providers and patients. Internet platforms, such as mobile applications, are potential tools to overcome these barriers and improve patient access to education and management options for FSD.

Objective
The purpose of this review is to identify existing applications addressing female sexual health and evaluate their educational content and services.

Methods
We searched the internet and Apple App Store for key words including: “sexual wellness app for women”, “female sexual health app”, “best sex apps for women”, “sexual health for women”, “sexual health”, “sexual wellness”. A panel of female pelvic medicine and reconstructive surgery experts reviewed the apps for quality of content, scientific basis of provided information, interactivity, usability and whether they would recommend it as a reference tool for patients.

Results
Of the 204 apps identified, 182 were excluded based on unrelated content (sex frequency trackers, ovulation trackers, sex games for couples, etc.). Two applications did not work and three were meant to be used with a vibrator. Total of 17 apps were analyzed and divided into five categories: educational (6), emotions and communication (2), relaxation and meditation (4), general sexual health (2), and social and fun (3). Among these 17 apps, eight required either a one-time payment ($4.99- 9.99) or annual subscription ($23-120) and two apps were advertisement driven. The apps from the educational category were reviewed in further details. All of the educational apps provided scientific information in collaboration with health experts, however only three offered interactive features. When assessed for usability, one app received good (70) and five received excellent (97.5) scores based on the System Usability Scale (SUS). The majority of the apps (5) provided information on pathology and treatments of orgasmic dysfunction, but only one app, created by a physician, provided information on all categories of female sexual dysfunctions. The reviewers identified only one app that they would recommend as a credible resource for patients to use.

Conclusions
Internet apps provide an ideal platform for women to learn about sexual health and female sexual dysfunction, which is rarely addressed by their healthcare providers. Apps may also serve as a valuable reference for providers. Our review of relevant apps available on the Apple App Store revealed only six with evidence-based information, and only one that would be recommended to patients by experts in the field. Clearly, there is a need for more accessible, educational resources addressing female sexual dysfunction for patients and providers.

Disclosure
No
Inspiring Sexual Attitude Reassessment (SAR)
Authors: Zal F 
Published: July 2022

ABSTRACT

Introduction
This article will outline exemplary practices in teaching a Sexual Attitude Reassessment (SAR). SAR is sometimes colloquially referred to as diversity, equity, inclusion, and intersectionality training in the field of sexology. However, SAR is much more than that. SAR is a bridge 'from' cis-hetero-monogamous-ableist kyriarchy and other forms of erotic marginalization 'to' embodiment, loving kindness, compassion, compersion, and equanimity.

Objective
Stop the perpetuation of sexual shame, stigma, and other harms through meta-cognition, increased sexual world-view, professional boundaries, and triadic professional relationships for compassionate client support and equity formation.

Methods
Analysis of SAR lesson plans from multiple leaders in the field, to compare and critique methods and pedagogy utilized.Literature review of books, dissertations, and peer-reviewed journal publications on SAR.Professional recommendations based upon research and analysis.

Results
SAR is an opportunity for each participant to recognize and critically examine our internalized shame, stigma, aversion, and joy. Through this process of collaborative reflection, dialogue, and meta-cognition; we can learn to address the hidden narratives that might guide and/or foreclose our potential personal lives and to minimize harmful perpetuation of shame and stigma to clients, colleagues, family, and community. Physician, first heal thyself!It is important to understand that while as SAR is a required course for AASECT certification; it is the potential first of many experiential steps along the path of personal and professional exploration that will unfold across one's lifespan. SAR is a critical examination of one's sexual beliefs and values. A way of challenging the world as we know it to exist by purposefully confronting different worldviews, cultures, abilities, sexual orientations, gender identities, socioeconomic status, and social histories via lived experiences. SAR is also a nurturing space that encourages the growing process and facilitates brave learning.

Conclusions
Recommendations will be made around sexually explicit media, live / virtual formats, group discussion formats, positionality, vulnerability, and other resources.

Disclosure
No
Impact of Infertility on Female Sexual Function
Authors: Agarwal N , Bachmann G , Phillips N 
Published: July 2022

ABSTRACT

Introduction
Infertility, known to have a negative impact on couples, may cause significant distress in a relationship and can potentially lead to/or exacerbate sexual dysfunction. The physical, psychological, and often financial strains of infertility treatments, with potential failure to achieve the desired pregnancy can all contribute to this stress. Additionally, sex may be seen as becoming a medical or therapeutic act, with loss of spontaneity and pleasure. Hence, infertility and sexual dysfunction can be interlinked. Despite this association, intervention with effective templates of care appears to be limited in addressing this issue.

Objective
A systematic literature review was done, focusing on female sexual dysfunction due to infertility and on what are available templates of care.

Methods
A Google Scholar and pub med search were done with keywords “sexual dysfunction,” “infertility,” and “couple.”

Results
Although there are many studies depicting the correlation between the infertility and sexual dysfunction, templates of management appear to be lacking. Data suggest that infertility is a major contributor to female sexual dysfunction. That is, not only the infertility diagnosis but also the duration of infertility contributes to the sexual dysfunction. Studies have shown the lubrication and orgasm issues are the woman's main concerns. Also, sexual dysfunction is more profoundly impaired in patients with secondary infertility, lower educational level and higher partner education.

Conclusions
These data suggest that couples undergoing infertility treatment should be evaluated for sexual dysfunction and be offered management during the infertility process. Sexual therapy does not appear to be routinely offered, despite the fact that these patients are at an increased risk of either developing a sexual dysfunction or a sexual dysfunction being exacerbated as a result of infertility as part of the infertility treatment process.

Disclosure
No
Could Hormone Levels Impact the Severity of Clitoral Phimosis?
Authors: Romanello J , Myers M , Nico E , Sussman R , Marantidis J , Rubin R 
Published: July 2022

ABSTRACT

Introduction
Clitoral adhesions (CA) occur when the prepuce adheres to the glans clitoris. CA can be classified as mild, moderate, or severe, based on if more than 75%, 25% to 75%, or less than 25% of the glans clitoris is exposed. Symptoms of CA include pain, difficulty with arousal, and muted or absent orgasm. There is a paucity of information on how hormone levels may contribute to the formation of CA. We hypothesize that patients with lower levels of free and total testosterone, and higher levels of the blood transport protein sex hormone binding globulin (SHBG) could have more severe adhesions. Higher free and total testosterone can yield more oily skin, which may break up or prevent adhesions. Additionally, with higher SHBG, there is less free testosterone available to be used by tissues in the body.

Objective
To determine if patients with lower free and total testosterone, and higher SHBG have more severe adhesions.

Methods
Charts of females with CA who underwent the non-surgical lysis procedure at one sexual medicine practice were considered for this study. 24 charts contained information on the severity of phimosis before lysis, total and free testosterone levels, as well as SHBG levels around the time of lysis. The study group consisted of patients with mild (n=9), moderate (n=8), or severe (n=7) CA.

Results
The average calculated free testosterone among patients with mild, moderate, and severe CA was 0.23ng/dL, 0.35ng/dL, and 0.14ng/dL. The average total testosterone among patients with mild, moderate, and severe CA was 24.79ng/dL, 27.81ng/dL, and 20.26ng/dL. The average SHBG among patients with mild, moderate, and severe CA was 98.69nmol/L, 95.76nmol/L, and 109.40nmol/L.

Conclusions
We predicted that patients with more severe adhesions would have lower levels of free and total testosterone, as well as higher levels of SHBG, yet this trend did not appear overall in this data among patients with mild, moderate, or severe adhesions. Additional studies with larger sample sizes are needed to explore the potential impact of free and total testosterone, as well as SHBG levels on the development and severity of CA. Studies could also compare levels of these hormones in patients with and without adhesions, or consider patients with recurrence of adhesions. Insight into a hormonal etiology could be important to patients with altered levels of these hormones - for example, patients with medical conditions such as PCOS, patients taking medications such as oral contraceptive pills, and menopausal women on oral estrogen (as increased estrogen raises levels of SHBG) could be at an increased risk for developing CA. Further studies could also consider if the clitoides of transgender males on gender-affirming hormone therapy with testosterone have lower incidences of CA.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Sprout (Raleigh, NC), Absorption Pharmaceuticals
Characteristics of Systemic Testosterone Therapy for Female Hypoactive Sexual Desire Disorder – A Claims Database Analysis
Authors: Kohn T , Dumas K , Kohn J , Agrawal P , Clifton M 
Published: July 2022

ABSTRACT

Introduction
Hypoactive sexual desire disorder (HSDD) is estimated to impact ∼10% of women but is commonly undiagnosed. Systemic testosterone therapy (alone or with estrogen) improves libido in women with HSDD; however, concern for adverse effects may limit broad utilization.

Objective
Our objective is to describe trends in systemic testosterone for HSDD using a large US claims database.

Methods
The TriNetX Diamond Network database was queried: a US health research network of 190 million patients, encompassing healthcare encounters and prescriptions. We identified female patients with HSDD (ICD-10 F52.0) without age limitation from 2010 to September 2021. Testosterone prescription trends (total prescriptions, number per patient, incidence over time [prescriptions/person-day] assessed in 2010-2012, 2013-2015, 2016-2018, and 2019-2021), route of administration, and coadministration with estrogen were extracted. Significance over time was assessed using Chi Square for trend.

Results
37,491 women diagnosed with HSDD were identified with mean age 46.5±12.4 years. Only 3.9% of women with HSDD (n=1444) were prescribed systemic testosterone (mean age 50.6±10.0 years). Over the past decade, there was a statistically significant increase in testosterone prescriptions for HSDD, specifically for women age 18-40 years and 41-55 years, as seen in Figure 1 (p&lt;0.05). Most prescriptions were for injectable testosterone (56.8%), while 29.3% were for topical testosterone and 13.9% with route unknown. 556 women received only 1 prescription for systemic testosterone, 327 received 2-3 prescriptions, 262 received 4-9 prescriptions, and 299 received 10+ prescriptions. Systemic estrogen was co-prescribed for 543 women and vaginal estrogen was co-prescribed for 259 women; 642 women received no estrogen prescription.

Conclusions
Systemic testosterone therapy for HSDD remains rare but its use has increased over time; duration, route, and co-administration with estrogen remain highly variable. Long-term compliance with systemic testosterone therapy remains relatively low.

Disclosure
No
Measuring consumers’ demand for nutrition attributes: an application to ready-to-heat meals
Authors: Zhang Qi , Gallardo R. Karina 
Published: July 2022

AbstractThis study analyzes consumers’ preferences for nutrition and convenience attributes in ready-to-heat meals, using grocery scanner data applied to a Berry, Levinsohn, and Pakes model. Households’ preferences for convenience meals stem on saving time. Also, households prefer convenience meals with higher contents of sugar, fat, sodium, cholesterol, and fiber, and lower in calorie content. Results prove that consumption of convenience foods implies a high intake of ingredients with negative consequences on dietary quality and health. Findings showcase the importance of the advancement and adoption of alternative food processing technologies that would circumvent the production of convenient foods high in non-healthy ingredients.
Making a difference – ausbau processes in Modern Written Finnish and Kven: How a group of loanwords marks a divergence between the Kven language and Modern Written Finnish
Authors: Niiranen Leena 
Published: July 2022

AbstractAusbau processes increase differences between two close written language varieties. Finnish and Kven are considered two ausbau languages today, in contrast to an earlier view which considered Kven to be a dialect of Finnish. In this article, ausbau processes are illustrated by comparing the use of eera verbs, a group constituting international and Scandinavian loanwords in the two languages. Most eera verbs were purged from Modern Written Finnish and they are expressed via other means today. By contrast, Kven accepts eera verbs in the same way as Old Written Finnish. Purism – perceived as avoidance of certain linguistic elements – is the explanation behind ausbau processes in this case, and purist attitudes reflect the identities of language planners. Eera verbs represent a small corner of language, yet their use differentiates Kven from Modern Written Finnish, and underscores the independence of Kven as a separate language.
Review of computer-generated hologram algorithms for color dynamic holographic three-dimensional display
Authors: Pi Dapu , Liu Juan , Wang Yongtian 
Published: July 2022

AbstractHolographic three-dimensional display is an important display technique because it can provide all depth information of a real or virtual scene without any special eyewear. In recent years, with the development of computer and optoelectronic technology, computer-generated holograms have attracted extensive attention and developed as the most promising method to realize holographic display. However, some bottlenecks still restrict the development of computer-generated holograms, such as heavy computation burden, low image quality, and the complicated system of color holographic display. To overcome these problems, numerous algorithms have been investigated with the aim of color dynamic holographic three-dimensional display. In this review, we will explain the essence of various computer-generated hologram algorithms and provide some insights for future research.
Manipulating the light-matter interactions in plasmonic nanocavities at 1 nm spatial resolution
Authors: Wen Bao-Ying , Wang Jing-Yu , Shen Tai-Long , Zhu Zhen-Wei , Guan Peng-Cheng , Lin Jia-Sheng , Peng Wei , Cai Wei-Wei , Jin Huaizhou , Xu Qing-Chi , Yang Zhi-Lin , Tian Zhong-Qun , Li Jian-Feng 
Published: July 2022

AbstractThe light-matter interaction between plasmonic nanocavity and exciton at the sub-diffraction limit is a central research field in nanophotonics. Here, we demonstrated the vertical distribution of the light-matter interactions at ~1 nm spatial resolution by coupling A excitons of MoS2 and gap-mode plasmonic nanocavities. Moreover, we observed the significant photoluminescence (PL) enhancement factor reaching up to 2800 times, which is attributed to the Purcell effect and large local density of states in gap-mode plasmonic nanocavities. Meanwhile, the theoretical calculations are well reproduced and support the experimental results.
Data-driven design of high-performance MASnxPb1-xI3 perovskite materials by machine learning and experimental realization
Authors: Cai Xia , Liu Fengcai , Yu Anran , Qin Jiajun , Hatamvand Mohammad , Ahmed Irfan , Luo Jiayan , Zhang Yiming , Zhang Hao , Zhan Yiqiang 
Published: July 2022

AbstractThe photovoltaic performance of perovskite solar cell is determined by multiple interrelated factors, such as perovskite compositions, electronic properties of each transport layer and fabrication parameters, which makes it rather challenging for optimization of device performances and discovery of underlying mechanisms. Here, we propose and realize a novel machine learning approach based on forward-reverse framework to establish the relationship between key parameters and photovoltaic performance in high-profile MASnxPb1-xI3 perovskite materials. The proposed method establishes the asymmetrically bowing relationship between band gap and Sn composition, which is precisely verified by our experiments. Based on the analysis of structural evolution and SHAP library, the rapid-change region and low-bandgap plateau region for small and large Sn composition are explained, respectively. By establishing the models for photovoltaic parameters of working photovoltaic devices, the deviation of short-circuit current and open-circuit voltage with band gap in defective-zone and low-bandgap-plateau regions from Shockley-Queisser theory is captured by our models, and the former is due to the deep-level traps formed by crystallographic distortion and the latter is due to the enhanced susceptibility by increased Sn4+ content. The more difficulty for hole extraction than electron is also concluded in the models and the prediction curve of power conversion efficiency is in a good agreement with Shockley-Queisser limit. With the help of search and optimization algorithms, an optimized Sn:Pb composition ratio near 0.6 is finally obtained for high-performance perovskite solar cells, then verified by our experiments. Our constructive method could also be applicable to other material optimization and efficient device development.
Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects
Authors: Topiwala A. , Taschler B. , Ebmeier K. P. , Smith S. , Zhou H. , Levey D. F. , Codd V. , Samani N. J. , Gelernter J. , Nichols T. E. , Burgess S. 
Published: July 2022

AbstractAlcohol’s impact on telomere length, a proposed marker of biological aging, is unclear. We performed the largest observational study to date (in n = 245,354 UK Biobank participants) and compared findings with Mendelian randomization (MR) estimates. Two-sample MR used data from 472,174 participants in a recent genome-wide association study (GWAS) of telomere length. Genetic variants were selected on the basis of associations with alcohol consumption (n = 941,280) and alcohol use disorder (AUD) (n = 57,564 cases). Non-linear MR employed UK Biobank individual data. MR analyses suggested a causal relationship between alcohol traits, more strongly for AUD, and telomere length. Higher genetically-predicted AUD (inverse variance-weighted (IVW) β = −0.06, 95% confidence interval (CI): −0.10 to −0.02, p = 0.001) was associated with shorter telomere length. There was a weaker association with genetically-predicted alcoholic drinks weekly (IVW β = −0.07, CI: −0.14 to −0.01, p = 0.03). Results were consistent across methods and independent from smoking. Non-linear analyses indicated a potential threshold relationship between alcohol and telomere length. Our findings indicate that alcohol consumption may shorten telomere length. There are implications for age-related diseases.