bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating cementation factor for bioturbated sandstones, Bhuj Formation, Kachchh Basin, India: a novel approach using triple-porosity model
Authors: Singh Ajendra , Dcunha Jason , Desai Bhawanisingh G. 
Published: February 2022

AbstractCementation factor has a crucial role in evaluating volumetric reserves for heterogeneous clastic reservoir. Bioturbation is a prominent source of heterogeneity existing in hydrocarbon-bearing formation across the world. The effect of bioturbation on the petrophysical properties of the clastic has not been comprehensively understood yet, especially its effect on cementation factor estimation. The precise description of such properties is beneficial in developing better volumetric estimates and optimizing field development planning. The present work discusses an approach to characterize cementation factor in bioturbated clastic Bhuj Formation, Kachchh Basin, India. In order to ascertain the cementation exponent for bioturbated media, an improved triple-porosity model is proposed by quantifying the total porous volume into three components, namely matrix 1, matrix 2 and bioturbated region. An equivalent resistance model is then developed by identifying the series and parallel relation between the two matrix components and the burrow. The experimental observations of electrical response indicated large variation in resistivity in vertical cores compared to horizontal cores. The decreased resistivity is due to the vertically aligned burrow which due to their enhanced porosity provides less tortuous path for current to flow. The triple-porosity model is validated with different porosity value of matrix 1, matrix 2 and burrow, and a cementation factor of 2.8 for higher bioturbated samples and 3 for lower bioturbated samples is obtained. This validates the previous understanding of enhanced flow and storage property and thereby produces a consistent way to evaluate total cementation factor. The correct estimation of cementation factor helps in precise evaluation of water saturation in bioturbated reservoirs.
Plan writing as a policy tool: instrumental, conceptual, and tactical uses of water management plans in California
Authors: Escobedo Garcia Nataly , Ulibarri Nicola 
Published: February 2022

Abstract
Numerous environmental regulations require organizations to codify prospective activities in a written plan. However, evidence suggests that many plans are never implemented, raising questions about why public agencies continually require plans, whether mandating plans allows agencies to meet their policy aims, and what additional purposes plans serve. Adopting concepts from literature on research utilization, we develop a plan use typology, defining instrumental use as occurring when the requirement to write a plan directly addresses a stated policy problem, conceptual use as occurring when the requirement to write a plan indirectly addresses a policy problem by raising awareness of an issue or improving governance capacity, and tactical use as occurring when the requirement to write a plan serves a political or symbolic purpose unrelated to solving the policy problem. We then apply the typology to four California statutes that require local and regional utilities to write water management plans. We first assess the statutes to identify the goals underlying the requirement to write a plan and assess what plan uses are emphasized in guidance documents and the written plans themselves. Lastly, we interview the plan writing organizations to capture their perspectives on the value and limitations of these plans. We find that legislators turn to plans to support instrumental and conceptual goals but that the plans themselves and the way they are used by authoring agencies primarily serve conceptual and tactical uses, suggesting a disconnect between the policy goals underlying plans and their actual use.
Hybrid model for exhaust systems in vehicle thermal management simulations
Authors: Ahmed Saad , Rottengruber Hermann , Full Markus 
Published: February 2022

AbstractUsing Vehicle Thermal Management (VTM) simulations to predict the thermal load experienced by components is a popular method within the automotive industry. The VTM simulation approach is fast becoming equivalent to conducting thermal load tests with prototypes for vehicles powered by internal combustion engines. This is especially true in the early development phase of the vehicle. The accuracy of the VTM simulations plays a pivotal role at them being accepted as an eventual replacement for physical testing. The correct prediction of thermal loads in VTM simulations depends on a multitude of different parameters, but the modelling of the exhaust system plays a central role in it. This is because the exhaust gas, and with it the exhaust system, is the primary source of heat in a vehicle powered by an internal combustion engine. The developed approach not only needs to be accurate but also modular enough to allow for different exhaust configurations to be tested. It also needs to be capable of integration into any VTM simulation workflow while maintaining an industrially acceptable turnaround time. This paper explores a new methodology to achieve these requirements. A 1D/3D hybrid approach to exhaust system modelling is presented. In this, the components that have an enthalpy change of the exhaust gas, such as the turbocharger, have been modelled as 1D and simple components such as pipes have been modelled in 3D. This has the advantage of combining the speed of 1D simulations with the spatial accuracy of 3D simulations. The method uses a unique three-code co-simulation technique for full vehicle VTM simulations. The coupling is between a 3D CFD software, a 1D simulation tool, and a Finite Element based thermal solver. The methodology was validated against experimental data for multiple loadcases. The results show good agreement with experiment within acceptable tolerances.
Apologies in South Asian Varieties of English: A Corpus-Based Study on Indian and Sri Lankan English
Authors: Degenhardt Julia , Bernaisch Tobias 
Published: February 2022

AbstractDespite notable recent exceptions (for instance Funke, 2020), corpus-based research into South Asian Englishes has so far concentrated on structural features. Thus, empirical pragmatic research in said varieties is still sparse, although there has been increasing interest in variational pragmatics in world Englishes (Schneider & Barron, 2008). For instance, requests have been examined in both native and non-native varieties of English. However, studies on apologies have largely focussed on first-language varieties of English (Deutschmann, 2003). Against this background, the present study investigates apology patterns in two South Asian second-language varieties of English, Indian and Sri Lankan English, and their historical input variety British English. With the help of the spoken parts of the respective components of the International Corpus of English, multifactorial analyses—including an improved form of random forests that explicitly takes interactions between several predictors into account—model the choice of sorry as opposed to other apology forms. Findings suggest quantitative differences in the use of sorry which are influenced by factors such as type of apology, topic and age or combinations of said factors. In sum, this study suggests that apology forms and frequencies are sensitive to the speakers’ regional background and sociobiographic factors as well as to structural and contextual parameters.
Migration into and out of Indian Reserves Between 2011 and 2016: a Study Using Census Data Linkage
Authors: Dion Patrice , Morency Jean-Dominique 
Published: February 2022

AbstractThe impact of migration on the sizes, composition, and well-being of First Nations communities and the motivations that triggered such migrations have long been a topic of interest among researchers. Exploiting a new data source, linkages of consecutive censuses, this study aims to portray migration into and out of Indian reserves, with a focus on the Indigenous population. Between 2011 and 2016, migrations into and out of reserves resulted in net losses for reserves. These migratory losses, however, did not prevent the population on reserve to continue growing. From a socioeconomic point of view, migrations had a net positive impact on reserves by contributing to increase the proportions of individuals who are employed, with relatively high incomes or relatively high education. Looking at the determinants of migration, and taking advantage of a multilevel framework, it is found that migration into and out of reserves is multidimensional, being influenced by factors at both individual and community levels. Out-migration seems to be governed mainly by the propensity of individuals at certain stages of life to leave the reserve, permanently or not. In contrast, in-migration appears more influenced by reserves’ characteristics, and its prevalence varies greatly from one reserve to another.
Electrophysiological Evidence of Enhanced Auditory Retrieval in Musically Trained Children
Authors: Paquet Anik , Simard France , Cadoret Geneviève 
Published: February 2022

Abstract. Musical practice enhances auditory processing in children as related to pitch perception or tonal discrimination. The purpose of this study was to examine whether these benefits also occur in auditory working memory by influencing its neural substrates. Two groups of children aged between 7 and 11 years old were compared using an auditory retrieval task with three conditions: frequency retrieval, duration retrieval, and control. Musician children had weekly private violin or cello lessons for at least 14 months, whereas non-musician children had no musical training. Results showed that musicians’ scores on the Gordon’s Primary Measure of Music Audiation test were significantly higher than non-musicians’ scores in the rhythm and tone conditions. On memory tasks, musicians outperformed non-musicians in frequency retrieval but not in duration retrieval. Differences in retrieval performance were associated with a larger P200-like waveform over frontal sites in musicians and a larger N400-like waveform over centro-parietal sites in non-musicians. A source current density analysis revealed differences in frontal activities between musicians and non-musicians, suggesting that musical training influenced the neural mechanisms supporting auditory retrieval in children. These results are in agreement with previous studies that showed a better auditory memory in musicians. Furthermore, they suggest that in children, the effect of musical training can be strong enough to positively influence higher-order auditory memory processes such as active retrieval, as well as their neural correlates.
Multicomponent Diffusion of Dusty Plasma in PMSE Including the Growth of Dust Particles
Authors: Li Zheng‐yuan , Ma J. X. , Li Hui , Wu Jian 
Published: February 2022

AbstractDusty plasma diffusion was applied to model the plasma response to perturbations in dust density, which yields small‐scale irregularities in electron density that are responsible for Polar Mesosphere Summer Echos. Previous diffusion models treated aerosols either as fixed‐charge dust or as multiple‐charge‐state dust using chemical rate equations. The growth of aerosol particles was previously considered in the study of layered structures in mesospheric clouds, but it has not been incorporated into dust diffusion. In this paper, a multicomponent diffusion of a dusty plasma, consisting of electrons, ions, and charged aerosols, is developed, accounting for the growth of the aerosols. It is shown that, for typical parameters in polar mesopause region, the evolution of the density structures of the dusty plasma undergoes an initial charging process (approximately 100 s), then an ambipolar diffusion process on ion time scale (approximately hundreds of seconds), and the aerosol diffusion on dust time scale (>104 s). Furthermore, the growth of the aerosols retards the dust diffusion and causes the transition from anticorrelation to correlation between the electron and ion density perturbations (contrary to only anticorrelation or correlation as in the case without considering the growth). The growth also bends the density profiles from upward shifting to downward sedimentation. In addition, larger initial grain radius and the width of the initial perturbation result in slower diffusion. The diffusion is much faster at 88 km than at 82 km.
Fluid Migration Before and During Slow Earthquakes in the Shallow Nankai Subduction Zone
Authors: Tonegawa Takashi , Takemura Shunsuke , Yabe Suguru , Yomogida Kiyoshi 
Published: February 2022

AbstractFluid migration in subduction zones is a key controlling factor of slow and megathrust earthquakes at plate boundaries. During the migration, seismic velocity and heterogeneous structures in its pathways may be temporarily perturbed, preferably triggering slow earthquakes. Here, we show that transient changes of seismic heterogeneity occurred 0–9 months before shallow slow earthquakes in the Nankai subduction zone, Japan, using very long‐term (6–10 years) records of ambient seafloor noise. The heterogeneity changes preceding to shallow slow earthquakes were observed near the margin of the source region, while concurrent changes primarily occurred in the source region. We propose that the heterogeneity changes are attributed to dynamic fluid migration, and the difference in timings reflects the pore pressure level in the corresponding source region. When fluids are supplied to a source region under relatively low pressure, fluids are leaked out from its downdip or updip side, and slow earthquakes occur not immediately but with a time delay of at most 9 months. In the high pore pressure case, slow earthquakes occur immediately with fluid migration from the source region. This study suggests that the heterogeneous seismic structure is possibly changed by fluid migration before slow earthquakes in the Nankai subduction zone.
Evolution of therapy for limited stage diffuse large B-cell lymphoma
Authors: Rojek Alexandra E. , Smith Sonali M. 
Published: February 2022

AbstractDiffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), with limited-stage DLBCL defined as stage I or II disease. Risk stratification, initial treatment options, and relapse patterns are distinct from advanced-stage DLBCL, but there is limited data on the impact of biologic features on outcome. Patients have excellent outcomes, with ~90% survival at 2 years. Over the past several years, sequential prospective trials and large registry studies have evaluated the optimal number of chemotherapy cycles and implemented PET-adapted approaches to reduce the need for radiotherapy. Special consideration must still be given to cases of bulky disease, extranodal disease, fully resected scenarios, and adverse biologic features such as high-grade B-cell lymphoma with double/triple hit rearrangements. This review presents the evolution of a modern management approach, with a discussion of recent treatment-defining studies.
Incidence and management of CAR-T neurotoxicity in patients with multiple myeloma treated with ciltacabtagene autoleucel in CARTITUDE studies
Authors: Cohen Adam D. , Parekh Samir , Santomasso Bianca D. , Gállego Pérez-Larraya Jaime , van de Donk Niels W. C. J. , Arnulf Bertrand , Mateos Maria-Victoria , Lendvai Nikoletta , Jackson Carolyn C. , De Braganca Kevin C. , Schecter Jordan M. , Marquez Loreta , Lee Erin , Cornax Ingrid , Zudaire Enrique , Li Claire , Olyslager Yunsi , Madduri Deepu , Varsos Helen , Pacaud Lida , Akram Muhammad , Geng Dong , Jakubowiak Andrzej , Einsele Hermann , Jagannath Sundar 
Published: February 2022

AbstractChimeric antigen receptor (CAR) T-cell therapies are highly effective for multiple myeloma (MM) but their impressive efficacy is associated with treatment-related neurotoxicities in some patients. In CARTITUDE-1, 5% of patients with MM reported movement and neurocognitive treatment-emergent adverse events (MNTs) with ciltacabtagene autoleucel (cilta-cel), a B-cell maturation antigen-targeted CAR T-cell therapy. We assessed the associated factors for MNTs in CARTITUDE-1. Based on common features, patients who experienced MNTs were characterized by the presence of a combination of at least two variables: high tumor burden, grade ≥2 cytokine release syndrome (CRS) or any grade immune effector cell-associated neurotoxicity syndrome (ICANS) after cilta-cel infusion, and high CAR T-cell expansion/persistence. Strategies were implemented across the cilta-cel development program to monitor and manage patients with MNTs, including enhanced bridging therapy to reduce baseline tumor burden, early aggressive treatment of CRS and ICANS, handwriting assessments for early symptom detection, and extended monitoring/reporting time for neurotoxicity beyond 100 days post-infusion. After successful implementation of these strategies, the incidence of MNTs was reduced from 5% to <1% across the cilta-cel program, supporting its favorable benefit–risk profile for treatment of MM.
Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia
Authors: Bhattacharya Dipabarna , Teramo Antonella , Gasparini Vanessa Rebecca , Huuhtanen Jani , Kim Daehong , Theodoropoulos Jason , Schiavoni Gianluca , Barilà Gregorio , Vicenzetto Cristina , Calabretto Giulia , Facco Monica , Kawakami Toru , Nakazawa Hideyuki , Falini Brunangelo , Tiacci Enrico , Ishida Fumihiro , Semenzato Gianpietro , Kelkka Tiina , Zambello Renato , Mustjoki Satu 
Published: February 2022

AbstractCD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with unknown etiology. In this study, we molecularly characterized a cohort of patients (n = 35) by studying their T-cell receptor (TCR) repertoire and the presence of somatic STAT5B mutations. In addition to the previously described gain-of-function mutations (N642H, Y665F, Q706L, S715F), we discovered six novel STAT5B mutations (Q220H, E433K, T628S, P658R, P702A, and V712E). Multiple STAT5B mutations were present in 22% (5/23) of STAT5B mutated CD4+ T-LGLL cases, either coexisting in one clone or in distinct clones. Patients with STAT5B mutations had increased lymphocyte and LGL counts when compared to STAT5B wild-type patients. TCRβ sequencing showed that, in addition to large LGL expansions, non-leukemic T cell repertoires were more clonal in CD4+ T-LGLL compared to healthy. Interestingly, 25% (15/59) of CD4+ T-LGLL clonotypes were found, albeit in much lower frequencies, in the non-leukemic CD4+ T cell repertoires of the CD4+ T-LGLL patients. Additionally, we further confirmed the previously reported clonal dominance of TRBV6-expressing clones in CD4+ T-LGLL. In conclusion, CD4+ T-LGLL patients have a typical TCR and mutation profile suggestive of aberrant antigen response underlying the disease.
Targeting ferroptosis in acute kidney injury
Authors: Ni Lihua , Yuan Cheng , Wu Xiaoyan 
Published: February 2022

AbstractAcute kidney injury (AKI) is a major public health problem with high incidence and mortality. As a form of programmed cell death (PCD), ferroptosis could be considered as a process of iron accumulation and enhanced lipid peroxidation. Recently, the fundamental roles of ferroptosis in AKI have attracted much attention. The network mechanism of ferroptosis in AKI and its roles in the AKI to chronic kidney disease (CKD) transition is complicated and multifactorial. Strategies targeting ferroptosis show great potential. Here, we review the research progress on ferroptosis and its participation in AKI. We hope that this work will provide clues for further studies of ferroptosis in AKI.
Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet
Authors: Kan Shuang , Li Rong , Tan Yanhui , Yang Fang , Xu Shaohua , Wang Lingzhu , Zhang Lijun , Sun Xuchen , Chen Xuanming , Yang Yuting , Shu Wei , Wan Huaibin , Chen Zheng-Feng , Liang Hong , Chen Ming 
Published: February 2022

AbstractObesity is a risk factor for many chronic diseases, and is associated with increased incidence rate of type 2 diabetes, hypertension, dyslipidemia and cardiovascular diseases. Adipocyte differentiation play critical role during development of obesity. Latexin (LXN), a mammalian carboxypeptidase inhibitor, plays important role in the proliferation and differentiation of stem cells, and highlights as a differentiation-associated gene that was significantly downregulated in prostate stem cells and whose expression increases through differentiation. However, it is unclear whether LXN is involved in adipocyte differentiation. The aim of this study was to evaluate the role of LXN on adipocyte differentiation, as well as its effects on high fat-induced obesity and metabolic disorders. In this study, we determine the expression of LXN in adipose tissue of lean and fat mice by Western blot, qPCR and immunohistochemistry. We found that LXN in fat tissues was continuous increased during the development of diet-induced obesity. We fed wild-type (WT) and LXN−/−mice with high-fat diet (HFD) to study the effects of LXN on obesity and related metabolic functions. We found that mice deficient in LXN showed resistance against high-fat diet (HFD)-induced obesity, glucose tolerance, insulin tolerance and hepatic steatosis. In vitro studies indicated that LXN was highly induced during adipocyte differentiation, and positively regulated adipocyte differentiation and adipogenesis in 3T3-L1 cells and primary preadipocytes. Functional analysis revealed that the expression of LXN was positively regulated by mTOR/RXR/PPARɤ signaling pathway during the differentiation of adipocytes, while LXN deletion decreased the protein level of PPARɤ in adipocyte through enhancing FABP4 mediated ubiquitination, which led to impaired adipocyte differentiation and lipogenesis. Collectively, our data provide evidence that LXN is a key positive regulator of adipocyte differentiation, and therapeutics targeting LXN could be effective in preventing obesity and its associated disorders in clinical settings.
The circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axis
Authors: Yan Yu , Nie Yu , Peng Chun , Xing Fuchen , Ji Saiguang , Liu Hong , Zhu Chuandong 
Published: February 2022

AbstractCircular RNAs (circRNAs) have been recognized as significant participants in the progression of different cancers; however, the detailed mechanisms of circRNAs in hepatocellular carcinoma (HCC) remain unclear. In this study, hsa_circ_0001394 was identified by RNA-seq analysis, and hsa_circ_0001394 was determined to be highly expressed in HCC specimens and cell lines. Patients with high expression of hsa_circ_0001394 tended to exhibit poor survival. Increased hsa_circ_0001394 expression in plasma was closely correlated with clinicopathological features including elevated vascular invasion and an advanced TNM stage, as indicated by alpha-fetoprotein (AFP) analysis. Hsa_circ_0001394 promoted the proliferation, migration, and invasion of HCC cells, whereas knockdown of hsa_circ_0001394 inhibited HCC tumorigenesis in vivo. In addition, mechanistic studies showed that miR-527 negatively interacted with hsa_circ_0001394. Furthermore, UBE2A was revealed to serve as a target of miR-527. Overall, the present study suggested that hsa_circ_0001394 may function as a sponge to promote HCC progression by regulating the miR-527/UBE2A pathway. Thus, hsa_circ_0001394 may become a promising biomarker and potential therapeutic target in HCC treatment.