bluuebunny/crossref_metadata_2025_split huggingface dataset:
More focal, less heterogeneous? Multi-level meta-analysis of cathodal high-definition transcranial direct current stimulation effects on language and cognition
Authors: Ostrowski Jan , Svaldi Jennifer , Schroeder Philipp A. 
Published: May 2022

AbstractHigh-definition transcranial direct current stimulation (HD-tDCS) is a relatively focal, novel non-invasive brain stimulation method with the potential to investigate the causal contributions of specific cortical brain regions to language and cognition. Studies with HD-tDCS typically employ a 4 × 1 electrode design with a single central target electrode surrounded by four return electrodes, among which return current intensity is evenly distributed. With cathodal HD-tDCS, neural excitability in the target region is assumed to be reduced, which offers interesting perspectives for neuropsychological research and interventions. This multi-level meta-analysis compiles published studies using cathodal HD-tDCS in 4 × 1 configuration to modulate cognition and behavior. Regarding HD-tDCS, 77 effect sizes were gathered from 11 eligible reports. We extended this database with 52 effect sizes from 11 comparable reports using conventional tDCS with cathodal polarity. We observed no significant overall effect and no moderation by within-study and between-study variables in HD. In the extended analysis, results suggested a non-linear moderation of cathodal tDCS effects by intensity, driven by negative effect sizes at 1.5 mA. However, studies varied tremendously in task parameters, outcomes, and even technical parameters. Interestingly, within-study heterogeneity exceeded between-study heterogeneity in the present sample, and moderators hardly reduced the residual heterogeneity. Across domains and configurations, both positive and negative effect sizes are possible. We discuss the findings in relation to conventional cathodal tDCS and the framework of polarity specificity. Fundamental aspects of cathodal HD-tDCS are still to be addressed in future research.
Geographical variation in ADHD: do diagnoses reflect symptom levels?
Authors: Widding-Havneraas Tarjei , Markussen Simen , Elwert Felix , Lyhmann Ingvild , Bjelland Ingvar , Halmøy Anne , Chaulagain Ashmita , Ystrom Eivind , Mykletun Arnstein , Zachrisson Henrik Daae 
Published: May 2022

AbstractRates of ADHD diagnosis vary across regions in many countries. However, no prior study has investigated how much within-country geographic variation in ADHD diagnoses is explained by variation in ADHD symptom levels. We examine whether ADHD symptom levels explain variation in ADHD diagnoses among children and adolescents using nationwide survey and register data in Norway. Geographical variation in incidence of ADHD diagnosis was measured using Norwegian registry data from the child and adolescent mental health services for 2011–2016. Geographical variation in ADHD symptom levels in clinics’ catchment areas was measured using data from the Norwegian mother, father and child cohort study for 2011–2016 (n = 39,850). Cross-sectional associations between ADHD symptom levels and the incidence of ADHD diagnoses were assessed with fractional response models. Geographical variation in ADHD diagnosis rates is much larger than what can be explained by geographical variation in ADHD symptoms levels. Treatment in the Norwegian child and adolescent mental health services is free, universally available upon referral, and practically without competition from the private sector. Factors beyond health care access and unequal symptom levels seem responsible for the geographical variation in ADHD diagnosis.
Effect of PEG grafting density on surface properties of polyurethane substrata and the viability of osteoblast and fibroblast cells
Authors: Abreu-Rejón A. D. , Herrera-Kao W. , May-Pat A. , Ávila-Ortega A. , Rodríguez-Fuentes N. , Uribe-Calderón J. A. , Cervantes-Uc J. M. 
Published: May 2022

AbstractThe surface of Tecoflex SG-80A Polyurethane (PU) films was modified by grafting polyethylene glycol (PEG) chains at three different molar amounts (0.05, 0.10, and 0.15 mmol). The resulting substrata were characterized by FTIR-ATR, TGA, AFM, SEM and contact angle to assess the surface modifications occurred during the grafting reactions. Osteoblasts and fibroblasts were cultured with PU extracts for 24 h, and their cell viability and morphology were evaluated by CellTiterBlue assay, Crystal Violet staining and Live/Dead assay. FTIR and TGA results indicated that PEG chains were successfully grafted onto PU surfaces, specifically in the hard segment of PU forming allophanate groups as the PEG grafting density increased. SEM and AFM images suggest that PU substrata were partially covered by PEG, increasing the dispersive and basic components of the PU surface energy. It was found that extracts from PEG-grafted polyurethanes increased the osteoblast viability, although fibroblasts viability remained constant regardless PEG grafting density; in spite of this both cells presented a more spread morphology at the lower PEG grafting density. Our results showed that surface energy of PU substrata can be tuned by PEG grafting density; also, the PEG leached tends to increase the pH of culture medium which leads to a higher viability of osteoblasts; nevertheless, PEG grafting density should be optimized to promote a healthy cell morphology as alterations in its morphology were detected at higher concentrations.
Does Being Authentic Promote Self-actualization at Work? Examining the Links Between Work-Related Resources, Authenticity at Work, and Occupational Self-actualization
Authors: Maunz Lucas Alexander , Glaser Jürgen 
Published: May 2022

AbstractAuthenticity at work (AAW) is an important work-related state. Little is known about how other work-related resources can promote AAW and the link between AAW and organizational self-actualization (OSA). In three studies, we drew on conservation of resource theory to determine whether AAW serves as a mediator between three distinct work-related resources (i.e., social support at work, job autonomy, authentic leadership) and OSA. Studies 1 and 2 used a cross-sectional design (Ns = 209; 597), and study 3 used a two-wave longitudinal design (N = 143) to evaluate data from employees. While studies 1 and 2 supported a positive, indirect relation between job autonomy, social support at work, and OSA via AAW, study 3 and additional post hoc findings challenged these results. Alternatively, a reciprocal, cross-lagged effect of OSA on AAW is plausible. Lagged effects from work-related resources to AAW or OSA were not supported in study 3. Authentic leadership (AL) was not related to OSA via AAW. Instead, post hoc analysis suggested two serially mediated links between AL and OSA. All three studies confirmed the proposed factor structures of AAW and OSA. The findings extend both our knowledge regarding the concepts of AAW and OSA and the promotion of AAW and its relation to OSA. We discuss the dynamics of work-related resources, AAW, and OSA and conclude with implications for future research, organizations, leaders, and employees.
Chronic Granulomatous Disease-Like Presentation of a Child with Autosomal Recessive PKCδ Deficiency
Authors: Neehus Anna-Lena , Tuano Karen , Le Voyer Tom , Nandiwada Sarada L. , Murthy Kruthi , Puel Anne , Casanova Jean-Laurent , Chinen Javier , Bustamante Jacinta 
Published: May 2022

Abstract
Background
Autosomal recessive (AR) PKCδ deficiency is a rare inborn error of immunity (IEI) characterized by autoimmunity and susceptibility to bacterial, fungal, and viral infections. PKCδ is involved in the intracellular production of reactive oxidative species (ROS).

Material and Methods
We studied a 5-year old girl presenting with a history of Burkholderia cepacia infection. She had no history of autoimmunity, lymphocyte counts were normal, and no auto-antibodies were detected in her plasma. We performed a targeted panel analysis of 407 immunity-related genes and immunological investigations of the underlying genetic condition in this patient.

Results
Consistent with a history suggestive of chronic granulomatous disease (CGD), oxidative burst impairment was observed in the patient’s circulating phagocytes in a dihydrorhodamine 123 (DHR) assay. However, targeted genetic panel analysis identified no candidate variants of known CGD-causing genes. Two heterozygous candidate variants were detected in PRKCD: c.285C > A (p.C95*) and c.376G > T (p.D126Y). The missense variant was also predicted to cause abnormal splicing, as it is located at the splice donor site of exon 5. TOPO-TA cloning confirmed that exon 5 was completely skipped, resulting in a truncated protein. No PKCδ protein was detected in the patient’s neutrophils and monocyte-derived macrophages. The monocyte-derived macrophages of the patient produced abnormally low levels of ROS, as shown in an Amplex Red assay.

Conclusion
PKCδ deficiency should be considered in young patients with CGD-like clinical manifestations and abnormal DHR assay results, even in the absence of clinical and biological manifestations of autoimmunity.
Heterogeneity in preferences for outcomes of integrated care for persons with multiple chronic diseases: a latent class analysis of a discrete choice experiment
Authors: Hoedemakers Maaike , Karimi Milad , Jonker Marcel , Tsiachristas Apostolos , Rutten-van Mölken Maureen 
Published: May 2022

Abstract
Purpose
For an integrated care programme to be successful, preferences of the stakeholders involved should be aligned. The aim of this study is to investigate to which extent outcomes beyond health are valued and to study the heterogeneity of preferences of those involved in integrated care.

Methods
A discrete choice experiment (DCE) was conducted to elicit preferences for eight Triple Aim outcomes, i.e., physical functioning, psychological well-being, social relationships & participation, enjoyment of life, resilience, person-centeredness, continuity of care and total health and social care costs. Stakeholders were recruited among Dutch persons with multi-morbidity, informal caregivers, professionals, payers, and policymakers. A Bayesian mixed-logit model was used to analyse the data. Subsequently, a latent class analysis was performed to identify stakeholders with similar preferences.

Results
739 stakeholders completed the DCE. Enjoyment of life was perceived as the most important outcome (relative importance: 0.221) across stakeholders, while total health and social care costs were perceived as least important (0.063). The latent class analysis identified four classes. The first class (19.9%) put most weight on experience with care outcomes. The second class (39%) favoured enjoyment of life. The third class (18%) focused relatively more on physical health. The fourth class (24%) had the least consistent preferences.

Conclusion
This study has highlighted the heterogeneity in views of stakeholders in integrated care on what is important in health(care) for persons with multi-morbidity. To accurately value integrated care a variety of outcomes beyond health–e.g., enjoyment of life and experience with care–should be taken into account.
A critical review with emphasis on recent pieces of evidence of Moringa oleifera biosorption in water and wastewater treatment
Authors: Benettayeb Asmaa , Usman Muhammad , Tinashe Coffee Calvin , Adam Traore , Haddou Boumediene 
Published: May 2022

AbstractThe increasing demand for using competent and inexpensive methods based on biomaterials, like adsorption and biosorption, has given rise to the low-priced alternative biosorbents. In the past few years, Moringa oleifera (MO) has emerged as a green and low-priced biosorbent for the treatment of contaminated waters with heavy metals and dyes, and given its availability, we can create another generation of effective biosorbents based on different parts of this plant. In this review paper, we have briefed on the application of MO as a miraculous biosorbent for water purification. Moreover, the primary and cutting-edge methods for the purification and modification of MO to improve its adsorption are discussed. It was found that MO has abundant availability in the regions where it is grown, and simple chemical treatments increase the effectiveness of this plant in the treatment of some toxic contaminants. The different parts of this miraculous plant’s “seeds, leaves, or even husks” in their natural form also possess appreciable sorption capacities, high efficiency for treating low metal concentrations, and rapid adsorption kinetics. Thus, the advantages and disadvantages of different parts of MO as biosorbent, the conditions favorable to this biosorption, also, the proposal of a logical mechanism, which can justify the high efficiency of this plant, are discussed in this review. Finally, several conclusions have been drawn from some important works and which are examined in this review, and future suggestions are proposed.
Epileptic seizure focus detection from interictal electroencephalogram: a survey
Authors: Islam Md. Rabiul , Zhao Xuyang , Miao Yao , Sugano Hidenori , Tanaka Toshihisa 
Published: May 2022

AbstractElectroencephalogram (EEG) is one of most effective clinical diagnosis modalities for the localization of epileptic focus. Most current AI solutions use this modality to analyze the EEG signals in an automated manner to identify the epileptic seizure focus. To develop AI system for identifying the epileptic focus, there are many recently-published AI solutions based on biomarkers or statistic features that utilize interictal EEGs. In this review, we survey these solutions and find that they can be divided into three main categories: (i) those that use of biomarkers in EEG signals, including high-frequency oscillation, phase-amplitude coupling, and interictal epileptiform discharges, (ii) others that utilize feature-extraction methods, and (iii) solutions based upon neural networks (an end-to-end approach). We provide a detailed description of seizure focus with clinical diagnosis methods, a summary of the public datasets that seek to reduce the research gap in epilepsy, recent novel performance evaluation criteria used to evaluate the AI systems, and guidelines on when and how to use them. This review also suggests a number of future research challenges that must be overcome in order to design more efficient computer-aided solutions to epilepsy focus detection.
An Attempt to Explain Visual Aesthetic Appreciation
Authors: Grinde Bjørn , Husselman Tammy-Ann 
Published: May 2022

AbstractWe suggest an evolutionary based explanation for why humans are preoccupied with aesthetic aspects of visual input. Briefly, humans evolved to be swayed by positive and negative feelings in the form of rewards and punishments, and to pursue situations that induce rewards, even when the feeling is not sufficiently strong to be recognized as a reward. The brain is designed to offer rewards when a person focuses on certain types of visual stimuli. For example, warm colors are typically pleasant because they are associated with edible fruits, and complex images appeal to curiosity. At some point people began exploiting these types of brain rewards by beautifying objects and creating art. The utility of objects, and the associative (or communicative) aspects of art, may dominate the design, but the artist tends to add aesthetic elements. These elements imply visual aspects that do not add to the functional value or evoke memories or associations based on easily recognized features in the picture. The adaptive rationale for the rewards offered by the aesthetic elements should help explain human aesthetic appreciation.
Optimization of the Biostabilization Process of an Italian Mechanical–Biological Treatment Plant to Account for Changes in Waste Composition
Authors: Lombardi Francesco , Zingaretti Daniela , Verginelli Iason , Costa Giulia 
Published: May 2022

AbstractIn this paper, we present a case study on the optimization of the biostabilization process of an Italian mechanical–biological treatment (MBT) plant to account for changes in feed waste composition related to a progressive increase in separate collection of MSW fractions, biowaste in particular. After ten years of operation (2009–2019), a decrease of the stabilization degree of the output material of the plant was detected, with Dynamic Respiration Index (DRI) values above the established limit of 1,000 mgO2/kgVS/h (average values of 4,000 mgO2/kgVS/h determined weekly for eight weeks). The investigations carried out in 2019 on the waste samples feeding the MBT plant showed that paper and plastic materials constitute around 75% of the input waste to the two aerobic bioreactors of the MBT plant, against 55% at the start-up (2009). Furthermore, the airflow rates and the moisture content analyzed weekly for eight weeks in the bioreactors resulted below the optimal values suggested in the literature. To improve the performances of the biostabilization process, a series of modifications were implemented in the plant. The main modification involved the primary mechanical treatment by varying the mesh size of the screens to 50 mm circular holes mesh. Furthermore, the configuration of the aerobic bioreactors was changed by placing the two bioreactors in series (instead of the previous configuration in parallel) and using a screening unit (25 mm) between the two bioreactors instead of at the end of the process. In this way, the residence time of the materials in the aerobic treatment was enhanced from 16 days with the previous configuration to 27 days. Together with an increase of the airflow rates of around 40% and a water supply of approximately 10% in the bioreactors, these modifications allowed to achieve the desired stability of the output waste, with DRI values below 1000 mgO2/kgVS/h.
Graphical Abstract
The Dialectics of Action and Technology in the Philosophy of Jean-Paul Sartre
Authors: Siegler Marcel 
Published: May 2022

AbstractThis investigation provides an in-depth exploration of the dialectics of action and technology in the works of French philosopher Jean-Paul Sartre, both in terms of the concrete use contexts of technological artifacts and the entanglement between individual agents and their sociotechnical surroundings. Furthermore, it briefly outlines some potentials of Sartre’s thoughts for debates in contemporary philosophy of technology. Throughout his works, Sartre approaches human action from different yet dialectically interrelated perspectives that are always accompanied by and developed in relation to reflections about technology. Against the background of a complementary conception of human action that is derived from Sartre’s major works, the implementation of matter in the course of action primarily represents an instrumentalization. Things are thus always disclosed as implement things due to the practical character of human existence. Although things do not prescribe action, the material characteristics and properties of these things render them more useful for attaining some and more adverse for attaining other ends. Despite the ontological freedom of human beings, their position in societal forms of organization, to which Sartre refers to as practical ensembles, delimits their choice of means and necessitates them to satisfy their needs and desires with the limited means available. In this way,la force des chosesarises, not as a result of the characteristics of technology but as an outcome of sociality and politics.
Trophic analysis of a historical network reveals temporal information
Authors: Shuaib Choudhry , Syed Mairaj , Halawi Danny , Saquib Nazmus 
Published: May 2022

AbstractTrophic analysis exposes the underlying hierarchies present in large complex systems. This allows one to use data to diagnose the sources, propagation paths, and basins of influence of shocks or information among variables or agents, which may be utilised to analyse dynamics in social, economic and historical data sets. Often, the analysis of static networks provides an aggregated picture of a dynamical process and explicit temporal information is typically missing or incomplete. Yet, for many networks, particularly historical ones, temporal information is often implicit, for example in the direction of edges in a network. In this paper, we show that the application of trophic analysis allows one to use the network structure to infer temporal information. We demonstrate this on a sociohistorical network derived from the study of hadith, which are narratives about the Prophet Muhammad’s actions and sayings that cite the people that transmitted the narratives from one generation to the next before they were systematically written down. We corroborate the results of the trophic analysis with a partially specified time labelling of a subset of the transmitters. The results correlate in a manner consistent with an observed history of information transmission flowing through the network. Thus, we show that one may reconstruct a temporal structure for a complex network in which information diffuses from one agent to another via social links and thus allows for the reconstruction of an event based temporal network from an aggregated static snapshot. Our paper demonstrates the utility of trophic analysis in revealing novel information from hierarchical structure, thus showing its potential for probing complex systems, particularly those with an inherent asymmetry.
Zwischen Iterativität und Exzeptionalität, Deskription und Performanz
Authors: Mattern Tanja 
Published: May 2022

ZusammenfassungDie in der zweiten Hälfte des 12. Jahrhunderts entstandenen Visionsbücher Elisabeths von Schönau sind ein bemerkenswert frühes Beispiel der Texte, die vor dem Hintergrund monastischer Reformen liturgische Erfahrung als chronologische Grundstruktur nutzen und sie zum Ausgangspunkt wiederkehrender Visionen machen. Diese changieren daher zwischen der Exzeptionalität des jeweiligen ekstatischen Erlebnisses und der an die Liturgie gebundenen Iterativität bestimmter Offenbarungen. In diesem chronologischen Rahmen wird die Transzendenz als sinnlich wahrnehmbare räumliche Schau erfahren, in der besonders himmlisches und biblisches Geschehen deskriptiv erfasst oder in einer an liturgienahe Feiern und geistliche Spiele erinnernde Weise performativ inszeniert wird. Ziel des Beitrags ist es, diese literarische Verfasstheit und die ästhetische Gestaltung und Verknüpfung von Liturgie und Vision in Elisabets oft unterschätztem Liber Visionum genauer zu analysieren.