bluuebunny/crossref_metadata_2025_split huggingface dataset:
New tetrahydroisoquinolines bearing nitrophenyl group targeting HSP90 and RET enzymes: synthesis, characterization and biological evaluation
Authors: Bakhite Etify A. , Hassanien Reda , Farhan Nasser , Sayed Eman M. , Sharaky Marwa 
Published: February 2025

Abstract
In this study, new tetrahydroisoquinoline compounds were synthesized by reaction of 7-Acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8- (3-nitrophenyl or 4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2H)-thiones with methyl iodide, chloro acetonitrile, ethyl chloroacetate to produce compounds 3–5 and reacted with N-arylchloroacetamides reagents to gave tetrahydroisoquinolin-3-ylthio) acetamides compounds 6a–c, 8a–b which can cyclized to 6,7,8,9-tetrahydrothieno[2,3-c]Isoquinoline-2-carboxamides compounds 7a–c, 9a–b. Also react with N-(benzthiazol-2-yl)-2-chloroacetamideto give compound 10. The structures of all newly synthesized compounds were characterized by elemental and spectral analyses. Also, most of the synthesized compounds were evaluated for their anticancer activities aganist MCF7 and HEPG2 cell lines. From the result we found that the most active compound against the MCF7 cell lines was compound 8b, and the most active compound against HEPG2 cell lines was compound 3. Then the effects of compound 3 on the HEPG2 cell line was investigated using an apoptotic Annexin V-FITC test and flow cytometry. Compound 3 induced a 59-fold increase in HEPG2 cell line apoptosis and cell cycle arrested at the G0-G1, G2/M phases. Moreover, the molecular docking study was applied and the result showed that compounds 8b bind to the RET enzyme with binding energies of − 6.8 kcal/mol in comparison with standard alectinib, which exhibits a binding energy of − 7.2 kcal/mol. Compound 3 can bind with HSP 90 with a binding energy (ΔG) of − 6.8 kcal/mol, which was comparable to the standard Onalespib (− 7.1 kcal/mol).

Graphical Abstract
Neuroprotective effects of berberine in preclinical models of ischemic stroke: a systematic review
Authors: Laein Ghasem Dolatkhah , Boumeri Elahe , Ghanbari Saghar , Bagherian Amin , Ahmadinasab Fatemeh , Poudineh Vahid , Payandeh Shima , Rashidi Negar 
Published: February 2025

Abstract

Background/Objective
Berberine, a naturally occurring alkaloid, has shown promise as a neuroprotective agent in preclinical models of ischemic stroke. This systematic review aims to comprehensively evaluate the neuroprotective effects of berberine in animal models of cerebral ischemia and elucidate its potential mechanisms of action.

Methods
A systematic search was conducted across nine databases, including PubMed, Embase, Cochrane CENTRAL, Web of Science, Scopus, ScienceDirect, Europe PMC, DOAJ, and Google Scholar, from inception to June 30, 2024. Controlled in vivo studies investigating the neuroprotective effects of berberine in animal models of focal cerebral ischemia were included. Two independent reviewers screened studies, extracted data, and assessed the risk of bias using the SYRCLE tool.

Results
Eighteen studies met the inclusion criteria, encompassing various animal models of ischemic stroke. Berberine treatment consistently resulted in significant reductions in infarct volume and improvements in neurological function compared to control groups. Specifically, berberine doses ranging from 10 mg/kg to 300 mg/kg significantly decreased infarct sizes (p < 0.05). Berberine also exhibited anti-inflammatory effects by reducing pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, and downregulating the TLR4/NF-κB signaling pathway (p < 0.05). Antioxidant effects were evidenced by decreased malondialdehyde levels and increased antioxidant enzymes like superoxide dismutase and glutathione (p < 0.05). Additional findings from studies with smaller sample sizes indicated that berberine reduced apoptotic cell death by decreasing TUNEL-positive cells and modulating apoptosis-related proteins, including increasing Bcl-2 and decreasing cleaved caspase-3 levels (p < 0.05). Berberine also promoted neurogenesis and synaptic plasticity by increasing the expression of BDNF, TrkB, and synaptic proteins SYP and PSD95 (p < 0.05), and enhanced autophagic flux by modulating key autophagy markers (p < 0.05). The risk of bias varied among studies, with some lacking detailed reporting on randomization and blinding procedures.

Conclusion
Berberine demonstrates significant neuroprotective effects in preclinical models of ischemic stroke through multiple mechanisms, including anti-inflammatory, antioxidant, anti-apoptotic, and neuroregenerative actions. These findings support the potential of berberine as a multifaceted therapeutic agent for ischemic stroke. Further well-designed clinical trials are warranted to confirm its efficacy and safety in human patients.
Cell lineage-specific differences in clinical behaviour of non-functioning pituitary adenomas – A systematic review and meta-analysis
Authors: van der Hoeven Loren S , Slagboom Tessa N A , Malekzadeh Arjan , Hoogmoed Jantien , Drent Madeleine L , Aronica Eleonora , Stenvers Dirk Jan , Pereira Alberto M 
Published: February 2025

Abstract

Context
Immunohistochemistry (IHC) of cell lineage-specific transcription factors (TFs) has been added to the histopathological classification of pituitary adenomas since 2017, resulting in new histopathological subtypes of TF+/hormone- non-functioning pituitary adenomas (NFPAs) and a reduction in the prevalence of null cell adenomas (NCAs).

Objective
To evaluate associations between expression of cell lineage-specific TFs by IHC and radiological invasion and prognosis of NFPAs.

Data sources
A literature search in Medline, Embase, and CENTRAL was performed from inception up to July 11th 2023.

Study selection
Eligible studies were cohort studies reporting on radiological invasion, recurrence and/or radiotherapy in patients with NFPAs who tested positive for one cell lineage-specific TF or negative for all three. Finally, 27 out of 1985 studies were included.

Data extraction
Two authors independently extracted data and critically appraised risk of bias using the QUIPS tool.

Data synthesis
Random-effects inverse variance models were used to pool effect sizes. Prevalence rate ratios (PRR) were calculated using the Mantel-Haenszel method. Cavernous sinus invasion was more prevalent in NCAs and TPIT+ NFPAs compared with SF1+ NFPAs (PRR 1.60, 95% confidence interval (CI) 1.22-2.08, I2 10%, 95% prediction interval (PrI) 1.23-2.06, p=0.0036, and PRR 1.43, 95% CI 1.21-1.70, I2 0%, 95% PrI 1.17-1.76, p=0.0017, respectively), and in NCAs compared with PIT1+ (PRR 1.44, 95% CI 1.01-2.06, I2 0%, 95% PrI 0.83-2.50, p=0.0454). Limited number of studies precluded data syntheses of recurrence and radiotherapy.

Conclusions
The use of cell lineage-specific TFs by IHC enables to detect histopathological subtypes of NFPAs with distinct clinical behaviour.
A study of the therapeutic effects of yoga on symptoms associated with ADHD in children: Systematic review and meta-analysis
Authors: Mu Xintong , Luo Yang , Jia HaiChang , Li Xinjia , Huang Jing 
Published: February 2025

Background: Attention-deficit/hyperactivity disorder (ADHD) is a chronic developmental disorder with a high prevalence in children and the long-term nature of treatment. Although the use of yoga as a non-pharmacologic treatment is increasing in the ADHD population, the conclusion of its effectiveness in treating symptoms in children with ADHD remains to be explored.
Objective: The primary goal of this meta-analysis was to systematically summarize and analyze the efficiency of yoga in treating symptoms such as attention problems, emotional problems, and behavioral control in children with ADHD, as well as to serve as a guide for further studies and therapeutic procedures in the management of ADHD in children.
Materials and methods: This study was conducted using the Cochrane Handbook and the PRISMA Guidelines Statement for Systematic Reviews. A total of five databases, PubMed, Embase, Cochrane, Web of Science, and Ovid, were searched up to December 2024. Excel was utilized for data extraction, and Review Manager was used for data processing, analysis, and literature quality evaluation.
Results: In all, nine publications were enrolled in the study, and 285 participants—142 in the experimental group and 143 in the control group—met the inclusion requirements. The intervention lasted between 2 and 20 weeks, and all study participants were between the ages of 3 and 15. The outcome metrics consisted of measures of five ADHD-related symptoms: inattention, sustained attention, hyperactivity/impulsivity, emotional instability, and anxiety.
Conclusion: The intervention of yoga had an ameliorative effect on several symptoms of inattention, sustained attention, emotional instability, and hyperactivity/impulsivity in children with ADHD, but not statistically significant on anxiety symptoms.
Comparative efficacy of different antihypertensive drug classes for stroke prevention: A network meta-analysis of randomized controlled trials
Authors: Yu Ding , Li Jun-xia , Cheng Yuan , Wang Han-dong , Ma Xin-di , Ding Tao , Zhu Zhong-ning 
Published: February 2025

Objective
The study aimed to compare the effectiveness of various antihypertensive drugs in preventing strokes in hypertensive patients.

Methods
We conducted a comprehensive search of PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov to identify randomized controlled trials (RCTs) investigating the efficacy of antihypertensive drugs in stroke prevention from inception until April 2023. A network meta-analysis in a Bayesian framework was performed using the random-effects model.

Results
This study included 88 RCTs involving 487,076 patients to investigate the effects of antihypertensive drugs in preventing stroke. Among these trials, 58 RCTs specifically focused on comparing the impact of such drugs on hypertensive subjects. In overall population, Angiotensin-converting enzyme inhibitor (ACEIs), Angiotensin receptor blockers (ARBs), Calcium channel blockers (CCBs), and Diuretics (DIs) demonstrated superiority over placebo in in reducing stroke, all-cause mortality, and cardiovascular mortality. CCBs and DIs outperformed β adrenergic receptor blockers (BBs), ACEIs, and ARBs in stroke reduction. However, when focusing on hypertensive patients, ACEIs, CCBs, and DIs proved superior to placebo in reducing stroke, all-cause mortality, and cardiovascular mortality. ARBs reduced stroke and all-cause mortality but lacked efficacy in reducing cardiovascular mortality. Of the various CCB subclasses, only the Dihydropyridines displayed efficacy in preventing stroke, all-cause mortality, and cardiovascular mortality. Among diuretic subclasses, thiazide-type DIs exhibited no efficacy in preventing all-cause mortality. ACEIs+CCBs were more effective than ACEIs or ARBs monotherapy in reducing stroke, more effective than ACEIs, ARBs, CCBs, or DIs monotherapy in reducing all-cause mortality, and more effective than ARBs in reducing cardiovascular mortality.

Conclusion
These findings suggest that ACEIs, dihydropyridine CCBs, and thiazide-like diuretics may provide superior prevention against stroke, all-cause mortality, and cardiovascular mortality in hypertensive patients. Combinations of ACEIs and CCBs may provide enhanced protection of stroke than ACEIs or ARBs monotherapy.
Impact of digital health on the quality of primary care for people with chronic noncommunicable diseases: A scoping review protocol
Authors: Xavier Pedro Bezerra , Silva Ísis de Siqueira , de Figueiredo Renan Cabral , de Araújo Aguinaldo José , da Silva Amanda Jéssica Bernardo , Uchôa Severina Alice da Costa 
Published: February 2025

Background
Chronic Non-Communicable Diseases (NCDs) represent a significant global challenge, especially in low- and middle-income countries. The introduction of digital health in Primary Health Care (PHC) has the potential to improve the quality of care for people with NCDs by offering tools such as telemedicine, mobile applications and other information and communication technologies. The aim of this study is to identify and map global experiences of using Information and Communication Technologies (ICTs) in primary care for non-communicable diseases and assess their impact on the quality of care in PHC.

Methods
This study presents a scoping review protocol based on the Joanna Briggs Institute criteria and the PRISMA-ScR guidelines. The review will be carried out in nine stages, including defining the aim and research questions, developing inclusion and exclusion criteria, and searching, selecting, extracting and analyzing the evidence. The databases consulted include MEDLINE/PubMed, JBI Evidence Synthesis and Open Science Framework.

Results
The review will identify and map global experiences in the use of ICTs in primary care for NCDs and assess their impact on the quality of care in PHC. It is hoped to find studies that address the use of digital technologies for early detection, management and follow-up of NCDs, as well as their integration with traditional health systems.

Conclusions
The integration of digital technologies into PHC has the potential to improve the quality of care, but it can also accentuate inequities. It is necessary to consider digital health literacy, access to tools, and legal and ethical aspects of data protection. The review will highlight the need for robust policies and adequate infrastructure to support the effective implementation of digital health in PHC.
Effects of speed, agility, and quickness (SAQ) training on soccer player performance—a systematic review and meta-analysis
Authors: Sun Min , Soh Kim Geok , Ma Shuzhen , Wang Xinzhi , Zhang Junlong , Yaacob Azhar Bin 
Published: February 2025

Background
Previous studies have reported on the impact of Speed, Agility, and Quickness (SAQ) training on the performance of soccer players. However, there is still controversy regarding the results. This systematic review and meta-analysis aim to accurately assess the effects of SAQ training on the performance of soccer players.

Methods
We conducted a comprehensive search on March 15, 2024, using Web of Science, PubMed, Scopus, and EBSCOhost. Eligibility criteria for selecting studies were established based on the PICOS framework: (i) Population—healthy soccer players; (ii) Intervention—SAQ training; (iii) Comparison condition (conventional training or traditional training); (iv) Outcome—physical performance (speed, agility, strength, etc.); (v) Study design—randomized controlled trials. The PEDro scale was employed to evaluate the methodological quality of each study, and a random-effects model was used for the meta-analysis.

Results
A total of 11 studies met the inclusion criteria for the systematic literature review. One study with low PEDro score was excluded, and one was excluded based on Cochrane bias risk assessment. Finally, 9 studies were included in the meta-analysis, comprising 498 soccer players. Overall, the results indicated a significant impact of SAQ training on physical qualities and dribbling speed among soccer players. Specifically, there was a moderate effect size for sprint performance (5m, 10m, 20m) (ES = 0.75; p < 0.01), change of direction ability (COD) (ES = 0.35; p < 0.001), power (vertical and horizontal jumps) (ES = 0.67; p < 0.01), while flexibility showed no significant impact (ES = 0.11; p > 0.05). Moreover, change-of-direction dribbling demonstrated a significant effect (ES = 0.58; p < 0.01).

Conclusion
Overall, SAQ training effectively enhances speed, COD, explosiveness, and change-of-direction dribbling specific performance in adolescent soccer players, particularly in sprinting. However, it does not have an advantage in improving flexibility. Further high-quality studies encompassing a broader range of exercises are needed to fully determine the effectiveness of SAQ training in improving other physical qualities and technical skills of soccer players, as well as ultimately enhancing match performance.
Risks of mortality for various phenotypes in patients with type 2 diabetes mellitus in the Novosibirsk region
Authors: Bondar I. A. , Shabelnikova O. Y. 
Published: February 2025

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a disease with high prevalence and early mortality, and identifying groups at risk for adverse outcomes is important in secondary prevention.AIM: To study clinical, metabolic and genetic risk factors for deaths in various clinical phenotypes in patients with type 2 diabetes mellitus in the Novosibirsk region.MATERIALS AND METHODS: A prospective cohort study was conducted of 2507 patients with T2DM. The follow-up duration was 6.3±2.5 years. Depending on the level of C-peptide and the HOMA-IR index, patients were divided into 3 phenotypes: insulinopenic (n=288), classic (n=1921), insulin-resistant (n=298). Fatal outcome for the period from 2014 to 31.12.2022 was recorded in 592 patients (23.6%). DNA isolation and genotyping of structural variants of the TCF7L2(rs7903146), ATM(rs11212617) genes were performed by PCR.RESULTS: The main cause of death in patients with T2DM in all phenotypes was CVD (63.8%). Patients with an insulin-resistant phenotype had a significantly shorter duration of diabetes at the time of death, 12.3±5.5 years, compared with the classic and insulinopenic phenotype (p<0.001). Risk factors for mortality from all causes according to multivariate Cox regression analysis (OR) were the duration of T2DM (1.043, p<0.001), the level of HbA1c (1.131, p<0.001), creatinine (1.013, p=0.002), the T allele of the TCF7L2(rs7903146) gene (OR=1.431, p=0.017) and allele C of the ATM(rs11212517) gene (OR=1.509, p=0.007). Predictors of cardiovascular death were HbA1c (OR=1.129, p=0.001), duration of diabetes (OR=1.041, p=0.002), creatinine level (OR=1.015, p=0.004), the T allele of the TCF7L2(rs7903146) gene (OR=1.719, p=0.005) and allele C of the ATM gene (OR=1.539, p=0.024).CONCLUSION: The study found that patients with an insulin-resistant had a poor prognosis. The main predictor of general and cardiovascular death was HbA1c. The T allele of the TCF7L2(rs7903146) gene increased the risk of overall mortality by 43.1%, the C allele of the ATM(rs11212617) gene by 50.9%.
L‐arginine ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in male metabolic syndrome rats
Authors: Tagami Kaito , Okuzawa Touko , Yoshida Keisuke , Mishima Rin , Obara Natsuki , Kunimatsu Asuko , Koide Mayako , Teranishi Tamami , Itakura Koji , Ikeda Katsuhide , Murohara Toyoaki , Nagata Kohzo 
Published: February 2025

AbstractL‐Arginine supplementation has beneficial effects on metabolic disorders in rodents. We here investigated the effects of exogenous L‐arginine on cardiac pathology and mitochondrial reactive oxygen species (ROS) production and dynamics in DahlS.Z‐Leprfa/Leprfa (DS/obese) rats, a model of metabolic syndrome (MetS). DS/obese rats and their lean homozygous littermate (DahlS.Z‐Lepr+/Lepr+, or DS/lean) controls were provided with drinking water containing 0.50% L‐arginine‐HCl or 0.85% L‐alanine (isonitrogenous control) from 13 to 17 weeks of age. L‐Arginine supplementation markedly alleviated hypertension without affecting cardiac injury in MetS rats. It also attenuated the increase in ROS production apparent in cardiac mitochondria isolated from MetS rats as well as suppressed the associated upregulation of Nox4 mRNA and protein in the heart. Furthermore, L‐arginine reversed the decrease in the size of cardiac mitochondria as well as changes in the expression of DRP1 and OPA1 proteins apparent in the L‐alanine–treated MetS rat heart. Cardiac arginase II gene expression and arginase activity were increased by L‐arginine treatment in MetS rats but not CONT rats. L‐Arginine supplementation thus ameliorated hypertension and cardiac mitochondrial abnormalities in MetS rats, with the lack of a cardioprotective effect possibly being due to increased arginase activity.
Local grammar and speech act analysis: a case study of compliments
Authors: Tang Mengyuan 
Published: February 2025

Abstract
As local grammar starts to receive attention in the field of corpus linguistics, this study examines the local grammar of the speech act of complimenting. Utilizing the corpus from the first three seasons of Modern Family, the research identifies ten functional categories, revealing both commonalities and individualities in their use based on explicit and implicit strategies. A total of 31 explicit compliment patterns and 2 implicit ones are classified. The application of local grammar offers a clear and holistic perspective, enriching corpus pragmatics and providing communicative instructions for EFL and ESL learners.
Estimating individual contributions to team success in women’s college volleyball
Authors: Powers Scott , Stancil Luke , Consiglio Naomi 
Published: February 2025

Abstract
The progression of a single point in volleyball starts with a serve and then alternates between teams, each team allowed up to three contacts with the ball. Using charted data from the 2022 NCAA Division I women’s volleyball season (4,147 matches, 600,000+ points, more than 5 million recorded contacts), we model the progression of a point as a Markov chain with the state space defined by the sequence of contacts in the current possession. We estimate the probability of each team winning the point, which changes on each contact. We attribute changes in point probability to the player(s) responsible for each contact, facilitating measurement of performance on the same point scale for different skills. Traditional volleyball statistics do not allow apples-to-apples comparisons across skills, and they do not measure the impact of the performances on team success. For adversarial contact groups (serve/reception and set/attack/block/dig), we estimate a hierarchical linear model for the outcome, with random effects for the players involved; and we adjust performance for strength of schedule not only on the conference/team level but on the individual player level. We can use the results to answer practical questions for volleyball coaches.
Effect of hybridization type, hole-distance and number of holes on the resistance of intraply hybrid composite plates against multiple impact
Authors: Deniz Mehmet Emin , Karakuzu Ramazan 
Published: February 2025

Abstract
In this study, the effects of the hole-distance from impact point and numbers of holes on carbon-glass/epoxy composite plates formed by three different intraply hybridizations subjected to repeated (multiple) impact loading with 8 J energy level are examined experimentally. The samples were subjected to multiple impact loading until perforation, which is determined by the impactor moving completely through the samples. The number of repeats for each sample was determined by the impactor perforating the sample. In order to better interpret the effect of the test parameters after of the impact tests, contact force-time and contact force-deflection, contact force-number of repeats and number of repeats-hybridization type change graphs of the samples are given for each hybridization type. Thus, the effects of both hybridization type and number and distance of holes on the repeated impact resistance of carbon-glass/epoxy intraply hybrid composite plates were investigated. Considering all test parameters, the absence of a hole and the hole’s near to the center of the sample significantly affects the sample stiffness, resulting in lower impact resistance. The presence of the hole and its distance from the impact point made the sample more resistant to impact. While the highest number of repeats was obtained for samples no-hole (d0h0), the lowest number of repeats was obtained for samples with four holes at a distance of 10 mm and 20 mm from the impact point. For all three hybridization types, the contact force value gradually decreased as the number of impact repeats of the samples increased. When the change in the damage areas of the samples was examined, the largest damage area occurred in the samples without holes (d0h0). Damage progression generally occurred in the 0° orientation of the lower layer.