bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a single intra-articular administration of stanozolol in a naturally occurring canine osteoarthritis model: a randomised trial
Authors: Alves J. C. , Santos A. , Jorge P. , Lavrador C. , Carreira L. Miguel 
Published: April 2022

AbstractOsteoarthritis (OA) is a disease with a high negative impact on patient’s quality of life and a high financial burden. It is a source of chronic pain and affects all mammals, including humans and dogs. As the dog is a common model for translation research of human OA, and exploring spontaneous dog OA can improve the health and well-being of both humans and dogs. To describe the effect of the intra-articular administration of stanozolol in a naturally occurring canine OA model, forty canine (N = 40) hip joints were randomly assigned to receive stanozolol or saline (control). On treatment day and at 8, 15, 30, 90, and 180 days post-treatment, several evaluations were conducted: weight distribution, joint range of motion, thigh girth, digital thermography, and radiographic signs. Also, synovial fluid C-reactive protein and interleukin-1 levels were evaluated. Results from four Clinical Metrology Instruments was also gathered. Results were compared with Repeated Measures ANOVA, with a Huynh–Feldt correction, paired-samples t-test, or Wilcoxon signed-rank test, with p < 0.05. OA was graded as mild (90%), moderate (5%), and severe (5%), including both sexes. They had a mean age of 6.5 ± 2.4 years and a bodyweight of 26.7 ± 5.2 kg. No differences were found between groups at treatment day in all considered evaluations. Weight distribution showed significant improvements with stanozolol from 15 days (p < 0.05) up to 180 days (p < 0.01). Lower values during thermographic evaluation in both views taken and improved joint extension at 90 (p = 0.02) and 180 days (p < 0.01) were observed. Pain and function scores improved up to 180 days. In the control group, radiographic signs progressed, in contrast with stanozolol. The use of stanozolol was safe and produced significant improvements in weight-bearing, pain score, and clinical evaluations in a naturally occurring canine OA model.
The medial occipital longitudinal tract supports early stage encoding of visuospatial information
Authors: Beyh Ahmad , Dell’Acqua Flavio , Cancemi Daniele , De Santiago Requejo Francisco , ffytche Dominic , Catani Marco 
Published: April 2022

AbstractVisuospatial learning depends on the parahippocampal place area (PPA), a functionally heterogenous area which current visuospatial processing models place downstream from parietal cortex and only from area V4 of early visual cortex (EVC). However, evidence for anatomical connections between the PPA and other EVC areas is inconsistent, and these connections are not discussed in current models. Through a data-driven analysis based on diffusion MRI tractography, we present evidence that the PPA sits at the confluence of two white matter systems. The first conveys information from the retrosplenial complex to the anterior PPA and runs within the cingulum bundle. The second system connects all peripheral EVC areas to the posterior PPA and corresponds to the medial occipital longitudinal tract (MOLT), a white matter pathway that is distinct from the cingulum and that we describe here in detail. Based on further functional connectivity analysis and meta-analytic data, we propose that the MOLT supports early stage encoding of visuospatial information by allowing direct reciprocal exchange between the PPA and EVC. Our findings may improve symptom interpretation in stroke and tumour patients with damage to the medial occipito-temporal region and call for revisiting current visuospatial processing models.
Receptor-mediated nonhost resistance in plants
Authors: Oh Soohyun , Choi Doil 
Published: April 2022

AbstractNonhost resistance (NHR) is a plant immune response that prevents many microorganisms in the plant’s environment from pathogenicity against the plant. Since successful pathogens have adapted to overcome the immune systems of their host, the durable nature of NHR has potential in the management of plant disease. At present, there is genetic and molecular evidence that the underlying molecular mechanisms of NHR are similar to the plant immune responses that occur in host plants following infection by adapted pathogens. We consider that the molecular basis of NHR is multilayered, conferred by physicochemical barriers and defense responses that are induced following molecular recognition events. Moreover, the relative contribution of each component may depend on evolutionary distances between host and nonhost plants of given pathogen species. This mini-review has focused on the current knowledge of plant NHR, especially the recognition of non-adapted pathogens by nonhost plants at the cellular level. Recent gains in understanding the roles of plasma membrane-localized pattern-recognition receptors (PRRs) and the cytoplasmic nucleotide-binding leucine-rich repeat receptors (NLRs) associated with these processes, as well as the genes involved, are summarized. Finally, we provide a theoretical perspective on the durability of receptor-mediated NHR and its practical potential as an innovative strategy for crop protection against pathogens.
Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease
Authors: Dwomoh Louis , Tejeda Gonzalo S. , Tobin Andrew B. 
Published: April 2022

Abstract
Alzheimer’s disease (AD) remains a major cause of morbidity and mortality worldwide, and despite extensive research, only a few drugs are available for management of the disease. One strategy has been to up-regulate cholinergic neurotransmission to improve cognitive function, but this approach has dose-limiting adverse effects. To avoid these adverse effects, new drugs that target specific receptor subtypes of the cholinergic system are needed, and the M1 subtype of muscarinic acetylcholine receptor (M1-mAChR) has been shown to be a good target for this approach. By using several strategies, M1-mAChR ligands have been developed and trialled in preclinical animal models and in human studies, with varying degrees of success. This article reviews the different approaches to targeting the M1-mAChR in AD and discusses the advantages and limitations of these strategies. The factors to consider in targeting the M1-mAChR in AD are also discussed.
Total hip arthroplasty in geriatric patients – a single-center experience
Authors: Anderson Philip Mark , Vollmann Peter , Weißenberger Manuel , Rudert Maximilian 
Published: April 2022

Background: As advanced age often leads to accumulating comorbidities, geriatric patients are endangered by serious events during total hip arthroplasty. This study was conducted to explore whether or not the benefit in terms of health-related quality of life (HRQoL) was comparable to younger patients. Methods: At a single academic center, 100 patients meeting the following inclusion criteria were retrospectively recruited: (1) primary arthritis of the hip leading to THA; (2) age 80 years or older at the time of surgery; (3) follow up of at least 12 months. For comparison, two further groups were recruited in the same manner, differing only in the age criterion: 100 patients aged 60–69 and 100 patients aged 70–79 at the time of hip replacement. The primary outcome was compared using the WOMAC and the EQ-5D score. The secondary outcome was determined by rates of orthopedic and non-orthopedic complications. Intragroup comparisons of the PROMS were performed by the non-parametric Wilcoxon test for paired samples. For intergroup comparisons of the PROMS, the Kruskal–Wallis-test was performed. Concerning categorial data, intergroup comparisons were performed by the Chi-Square test. The level of significance was set at 0.05. Results: Concerning the WOMAC score, neither the absolute values at 12 months after THA (p = 0.176) nor the amount of change relative to the values before surgery (p = 0.308) differed significantly between the 3 groups. Concerning the EQ-5D index the absolute values at 12 months after THA differed significantly (p = 0.008). Rates of orthopedic complications did not differ significantly (p = 0.631). Rates of non-orthopedic complications increased significantly with rising age (p = 0.033). Conclusions: Compared to younger patients, geriatric patients after THA have an equal improvement in hip-specific and general HRQoL. While rates of orthopedic complications are comparable too, non-orthopedic complications occur more frequently.
Recommendations for Care and Support of Female Rape Victims
Authors: Fryszer Lina Ana , Büttner Melanie , Etzold Saskia , Muetzel Elisabeth , Rall Katharina , Schellong Julia , David Matthias ,   Team of authors at Frauennotruf [Womenʼs Emergency Helpline] Frankfurt
Published: April 2022

Abstract
Introduction According to prevalence studies, at least 5% of all women in the Federal Republic of Germany experience rape during their lifetime. While the effects vary according to
the individual, rape has serious consequences for the somatic, psychological, and psychosocial health of the victim. The medical care that is provided to presumed rape victims is of special
importance, as this care can have a positive influence on the patientʼs ability to process their experience and engage in healing following such a traumatic event. Furthermore, doctors are
the professionals whose help is most often sought in this context. Primary care following rape consists of three aspects: the forensic medical examination, medical care, and psychological
care. In this position paper, each of these aspects are discussed in detail. Recommendations for follow-up care are also provided.
Methods In a multi-tiered process, a selective literature review was performed and a consensus among representative experts from different areas of specialization was formulated.
Goals The goal of this paper is to contribute to the further improvement and standardization of the medical care provided to women who are presumed rape victims.
Berberitze
Authors: März Henrike , Vigl Sebastian , Welsch Katja , Stern Cornelia 
Published: April 2022

SummaryDas Thema der „4 Fachleute – 4 Behandlungsstrategien“ in dieser Ausgabe ist der Einsatz der Berberitze in der Ernährungstherapie, Phytotherapie, Homöopathie und Spagyrik.
Von der Befruchtung zur Knospung
Authors: Corts Magga 
Published: April 2022

SummaryEs ist immer wieder ein Wunder, wie sich aus zwei Zellen (Eizelle und Samenzelle) innerhalb von 9 Monaten ein Säugling entwickeln kann. Um den Prozess zu verstehen, ist es wichtig, sich die Embryogenese genauer anzuschauen. Denn die Embryogenese, also die Entwicklung des Embryos, ist Grundlage jeglicher fetalen Entwicklung. Sie dauert bis zur 12. Schwangerschaftswoche (SSW).
Prüfungsthema: Pflanzen
Authors: Schmid Eva C. 
Published: April 2022

SummaryLiebe Heilpraktikeranwärter – mit diesen Karteikarten wollen wir Sie bei der Vorbereitung auf die mündliche Heilpraktikerüberprüfung unterstützen. Viel Erfolg beim Lernen wünscht Ihnen HP Eva C. Schmid!
Pflanzengeist in der Flasche
Authors: Houben Martina 
Published: April 2022

SummaryDie Herstellung und Anwendung Ganzheitlicher Urtinkturen rückt die Persönlichkeit und einzigartigen Fähigkeiten einer jeden Heilpflanze in den Vordergrund. Die Wesensqualität und Wirkung der Pflanzen lässt sich unter anderem über die Signatur und entsprechende Analogien, zum Beispiel das Sieben-Planeten-Prinzip, entschlüsseln. Anhand von zwei Fallbeispielen zeigt die Autorin, wie Ganzheitliche Urtinkturen körperliche und seelische Heilungsprozesse gleichermaßen unterstützen können.
Die Heilkraft der Fieberbäume
Authors: Vigl Sebastian 
Published: April 2022

SummaryBei der Behandlung der rheumatoiden Arthritis können Erkenntnisse der Schulmedizin helfen, phytotherapeutische Ansätze zu ermitteln. Einige Bäume enthalten entzündungshemmende Wirkstoffe, die bei rheumatoider Arthritis innerlich angewendet hilfreich sein können. Über die innerliche Anwendung hinaus können Heilpflanzen auch äußerlich bei rheumatoider Arthritis lindernd sein, insbesondere Pappelknospen.
OSG-Prothesen am arthritischen und arthrotischen
Fuß
Authors: Rehart Stefan 
Published: April 2022

ZusammenfassungBei den endgradigen Zerstörungen am oberen Sprunggelenk kommt heute den
operativen Verfahren der endoprothetischen Versorgung und der Versteifung die
entscheidende Rolle zu. Die 3 am meisten betroffenen Patientengruppen sind die
mit posttraumatischen, arthrotischen und rheumatischen Folgen. Es bestehen
fulminante Unterschiede in den pathophysiologischen Abläufen der
Gelenkaffektionen bei den primär degenerativen zu den
chronisch-entzündlichen Erkrankungen. Letztere unterliegen besonderen
lokalen, regionalen und systemischen Veränderungen, die in Bezug auf die
Differentialindikation und das gesamte perioperative Management bekannt sein
müssen, um Patienten optimal zu versorgen und Komplikationen zu
vermeiden. Beim „Rheumatiker“ gesellt sich zu den
immunologisch-induzierten Ko-Morbiditäten noch eine sehr gezielte
Basismedikation dazu, die in ihren orthopädisch-unfallchirurgischen und
den orthopädisch-rheumatologischen Auswirkungen zu bedenken ist. Initial
stehen die gesamten Verfahren der konservativen Behandlung am Sprunggelenk und
im Verlauf – vor allem bei entzündlich induzierten
Synovialitiden – eine Spiegelung mit Schleimhautresektion und
anschließender Radiosynoviorthese zur Verfügung. Zuletzt gewinnt
die technisch anspruchsvolle endoprothetische Versorgung am oberen Sprunggelenk
seit geraumer Zeit wieder mehr an Bedeutung, vielfach wird von
fußchirurgischen Experten jedoch eine Fusion des tibio-talaren Gelenkes
bei entsprechender Destruktion bevorzugt. In Deutschland werden rund 2000
OSG-TEP-Implantationen p.a. mit den heute üblichen zementfrei
eingesetzten 3-Komponenten-Prothesen ausgeführt, die -besonders bei den
rheumatischen Erkrankungen- mittelfristig recht gute Ergebnisse aufweisen.
Sowohl die TEP-Versorgung als auch die Fusionseingriffe weisen spezifische Vor-
und Nachteile sowie Komplikationsmuster auf. Die Indikation zu den Verfahren ist
individuell zu stellen. Fußchirurgische und
orthopädisch-rheumatologische Spezialisten für die jeweiligen
Patientengruppen können den Fachgesellschaftsseiten entnommen
werden.
Neither reckless nor free-riders: auditing the Baltics as US treaty allies
Authors: Banka Andris 
Published: April 2022

AbstractIs it strategically wise for the USA to stretch its protective umbrella over small nations in Eastern Europe? Prominent critics have faulted US allies for acting recklessly and free-riding on US security guarantees. The evidence presented vis-à-vis the Baltic States, however, challenges these assumptions. This study paints a picture of Estonia, Latvia, and Lithuania as loyalty-obsessed small states that diligently seek to meet their patron’s behavioural expectations. By word and deed, they back US strategic goals. As such, they have taken on heavy war burdens in US-led campaigns and sided with Washington in its geopolitical struggle against China. What is more, they bring to the table distinctive capabilities in cyber and intelligence. In sum, this paper suggests that the Baltic States have continuously reimbursed the USA for its defence-cover services.
Acute physiological, endocrine, biochemical and performance responses associated with amateur boxing: A systematic review with meta‐analysis
Authors: Finlay Mitchell J. , Greig Matt , Page Richard M. , Bridge Craig A. 
Published: April 2022

ABSTRACTPrevious research has explored the demands of amateur boxing‐specific activity; however, no holistic review of the acute responses to such activity currently exists. This paper aimed to provide a systematic review of the available literature on the acute physiological, endocrine, biochemical, and performance responses to amateur boxing‐specific activity. Following a search of EBSCOhost, SPORTDiscus, PubMed and Google Scholar databases, 25 studies were identified as meeting the inclusion criteria for the review. The methodological quality of the included studies was assessed via a modified Downs and Black checklist. Random‐effects meta‐analysis of standardised mean differences (SMD) revealed large (SMD = 4.62) increases in pre‐post blood lactate (BLa), cortisol (SMD = 1.33), myoglobin (Mb) (SMD = 1.43), aspartate transaminase (AST) (SMD = 1.37), and alanine aminotransferase (ALT) (SMD = 0.97), in addition to moderate increases in creatine kinase (CK) (SMD = 0.65). Small pre–post increases in counter‐movement jump (CMJ) height (SMD = 0.33) were observed. Consistently greater pre–post alterations were observed in competitive bouts, followed by sparring, and less so in boxing‐specific simulations. Considerable physiological, endocrine, and biochemical responses are elicited following amateur boxing. Interestingly, neuromuscular and task‐specific performance may not deteriorate following boxing‐specific activity. The findings of the review may assist in the designing and periodising of boxing‐specific training, dependent on the desired physical adaptations, training phase, and recovery status of the amateur boxer.Highlights
Amateur boxing elicits a considerable acute physiological, hormonal, and biochemical response.
Such responses are typically greater in competitive bouts, followed by sparring, and less so in simulated activity.
The considerable demands of amateur boxing‐specific activity do not appear to negatively affect neuromuscular or task‐specific performance.
Amateur boxers may be conditioned to preserve performance despite the acute demands of the sport, or the lack of performance decrement may reflect the short duration of amateur boxing.
Bayes' theorem, inflation, and the Ekpyrotic universe
Authors: Wraga Joseph , Goldberg David M. 
Published: April 2022

Abstract
We calculate the Bayesian evidences for a class of Ekpyrotic universe models, and compare with a model of single field inflation with a Higgs-type potential. Combining parsimony and observational constraints, this gives us a systematic way to evaluate the degree to which Ekpyrotic models are constrained by CMB data from Planck. We integrate the equations of motion numerically to define a likelihood using Planck 2018 data and sample this likelihood to obtain Bayesian evidences. Priors are justified and used to put Ekpyrotic models and inflation on equal footing. We find reasonable preference for one of the considered Ekpyrotic models over the others, but that even this one is disfavored compared with Higgs inflation.
MIRA: a multi-physics approach to designing a fusion power plant
Authors: Franza F. , Boccaccini L.V. , Fable E. , Landman I. , Maione I.A. , Petschanyi S. , Stieglitz R. , Zohm H. 
Published: April 2022

Abstract
Fusion systems codes (SCs) are deployed to produce the baseline of the European fusion power reactor (DEMO) within its conceptual design. A DEMO baseline is mostly defined by a radial/vertical reactor sketch and major reactor parameters, such as fusion and net electric power, magnetic fields, and plasma burn time. A baseline shall also meet a set of prescribed reactor requirements, constraints, and architectural features. According to the conceptual design workflow implemented within the EU-DEMO programme, the output from the SC is transferred to the detailed physics and engineering design codes. Presently-available fusion SCs rely on rather basic physics and engineering models (mostly at zero or one-dimensional level). The design codes, instead, are very detailed but run on much longer computing times. To fill the gap between systems and design codes, the multi-fidelity systems/design tool modular integrated reactor analysis (MIRA)—has been recently developed. MIRA incorporates the physics and the engineering insights of the utmost domains of tokamak reactors and relies on a higher spatial resolution, spanning from 1D up to 3D modelling frames. The MIRA approach has been applied to the DEMO 2017 baseline, generated by the EU reference SC PROCESS and used as input to MIRA. In the paper, the architectural and mathematical insights of the MIRA package are described, along with an EU-DEMO 2017 baseline analysis.
Application of Machine Learning in the Research of Evaporation Duct Height: A review
Authors: Chai Xingyu , Li Jincai , Zhao Jun , Zhao Xiaofeng 
Published: April 2022

Abstract
Evaporation duct is a kind of special atmospheric stratification that frequently appears on the sea surface, which has an important influence on the propagation and attenuation of electromagnetic waves, and is an important factor affecting the efficiency of marine radars and communication equipment. After the development in more than half a century, evaporation duct height can be obtained by direct detection, theoretical model, inversion and machine learning. Machine learning can explore the hidden laws of data efficiently and has the potential to surpass the traditional theoretical model. In this paper, the Machine Learning methods in evaporation duct research are shown and prospects of machine learning methods in evaporation duct research are given.
Multi robot navigation formation simulation based on ROS
Authors: Zhang Yuxing , Kong Xiangdong , Chen Xizhang 
Published: April 2022

Abstract
Multi-robot collaboration is an important development direction of current robotics technology. This paper proposes a navigator and follower model formation control framework that integrates path planning and trajectory tracking, and conducts experiments in the gazebo simulation environment to realize the simulation of navigation and formation led by the navigator in the simulation environment indoors.
D-H Parameter Method-based Wearable Motion Tracking
Authors: Qian Huizu , Chen Benbin , Xia Xuke , Deng Shengzhong , Wang Yuxiang 
Published: April 2022

Abstract
Motion capture is a key technology for robots to accurately understand pedestrian intentions in the scene of human-machine integration. Due to the limited spatial distance and easy obstruction by obstacles, traditional optical motion capture systems often lose detection targets. This paper proposes a wearable motion tracking method based on D-H parameter method. By binding multiple wireless inertial sensor units composed of accelerometers, magnetic flux sensors and gyroscopes to various moving parts of the user’s body, accurate and robust tracking of moving targets is achieved. This method uses the known pose information of the root node to find the pose state of each level in the reference coordinate system, and establishes the human body joint rotation model and the bone position state model. The results show that the motion tracking method proposed in this paper reduces 9 degrees of freedom compared with the traditional forward kinematics method, and the algorithm efficiency is increased by about 20%, which can accurately obtain the posture characteristics of the human body. It can be seen that the D-H parameter method is reasonable for the wearable human body motion tracking.
Network Anomaly Sequence Prediction Method Based on LSTM and Two-layer Window Features
Authors: Li Hongcheng , Gao Yuan , Wang Bing , Ming Yuewei , Zhao Zhongwei 
Published: April 2022

Abstract
To solve the over-fitting problem in the prediction algorithm caused by the small number of features that arise during the network anomaly prediction process, an LSTM algorithm for network anomaly predictions based on two-layer time window features was proposed. Firstly, the network alarm data sequence was divided according to the observation time window and prediction time window. Secondly, considering that the time series of the anomaly alarm data can be somewhat periodic, a time window sequence dataset was created with the periodic features and statistical features in the two-layer windows. Finally, one-shot and feedback models of the LSTM algorithm were employed to predict network anomalies. The experiment showed that the best prediction accuracy for this method is over 80% with both one-shot and feedback models, when the prediction time window is 12h.