bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplicación de la metodología de matrices de riesgo para un centro de medicina nuclear de alta complejidad basado en el seguimiento y análisis de incidentes radiológicos y desviaciones
Authors: Barbosa Parada Nathaly , Quiroz Revelo Beatriz Elena , Cruz Guerra Yuly Marcela , Sandoval Castillo Lorena , Cely Segura Xiomara , Niño Duarte Franklin 
Published: July 2022

El programa SEVRRA y la metodología de matrices de riesgo son iniciativas regionales para la implementación y uso de las evaluaciones de seguridad en prácticas médicas e industriales que emplean radiaciones ionizantes, en la búsqueda por mejorar la cultura de seguridad de estas instalaciones. En el presente estudio se adaptaron y revaluaron las metodologías y herramientas disponibles, a partir de una matriz de riesgo elaborada para la práctica de medicina nuclear diagnóstica y terapia radiometabólica, con lo cual se establecen métodos cuantitativos y se conocen los escenarios de exposición (cálculos de dosis-relación con efectos). Luego de la revisión y seguimiento de incidentes y desviaciones presentados en un periodo de cuatro años, se llegó a la necesidad de reevaluar la matriz inicial, y definir un procedimiento cíclico para el análisis de los sucesos iniciadores (SI) y las funciones de seguridad. Como resultado, se incluyeron 14 SI, 25 se eliminaron y 28 se modificaron; las funciones de seguridad aumentaron en la práctica de terapias radiometabólicas, mientras que para diagnóstico disminuyeron. En la matriz de riesgo final no se encontraron SI clasificados como riesgo alto, pero sí una disminución en los de riesgo medio y un aumento en los de riesgo bajo. El estudio del reporte de incidentes y su análisis permite concluir que no aumenta el nivel de riesgo asociado a la práctica evaluado con anterioridad, sino que disminuye, de igual forma muestra que la matriz de riesgo debe reevaluarse periódicamente conforme se implemente el programa de aseguramiento de la calidad.
Pengaruh Penerapan Good Corporate Governance dan Corporate Social Responsibility terhadap Kinerja Keuangan Perusahaan
Authors: Cahyaningrum Safira Putri , Titisari Kartika Hendra , Astungkara Agni 
Published: July 2022

The purpose of this analysis is to investigate whether good corporate governance and corporate social responsibility have an influence on the financial performance of a Manufacturing company that are registered on the Indonesia Stock Exchange. This study provides an overview of the affect of corporate governance and corporate social responsibility on a corporation’s financial performance. And in this case, institutional assets, independent commissioners, and audit committees are used to assess corporate governance. Quantitive method with purposive sampling use in this study. A sampel of 37 manufacturing companies was obtained from the above sampling, with a total of 155 observations reported on the Indonesia Stock Exchange during 2017 until 2021. The multiple linear regression analysis system is used in this data analysis technique. The findings revealed that corporate governance as proxied through of institutional assets had no large influence on the financial performance. Futher findings revealed that corporate governance as proxied through the audit committee had no large influence on the financial performance of the company. Meanwhile, corporate governance as proxied through the independent board of commissioners has a large affect on a company’s financial performance. The fndings above also revealed that corporate social responsibility has a no discernible affect on the company’s financial performance.
Determinan Rasio Keuangan dan Good Corporate Governance di Badan Usaha Milik Negara
Authors: Sabatini Lucky Monic , Nugraheni Siwi 
Published: July 2022

The study is classification as a quantitative study intended to see if there is any impact between a financial ratio and good corporate governance on the profitability of State-Owned Enterprises. A total of 14 State-Owned Enterprises were used as research samples from 2016-2020. Microsoft Excel 2007 and E-views 9 were used to process data using regression data analysis methods that panel as an analysis technique and used by the 5% level. Research has shown that profitability has been significantly influenced by liquidity and the board of directors, while profitability has been not significantly influenced by leverage, independent commissioners, and auditing committees.
Keywords: Financial Ratio, Good Corporate Governance, State-Owned Enterprises
Pengaruh Debt to Equity Ratio, Gross Profit Margin, Perputaran Piutang, dan Return on Equity terhadap Nilai Perusahaan pada Perusahaan Consumer Goods di Bursa Efek Indonesia Tahun 2018 – 2020
Authors: Hendry Jason Valerio , Sitorus Friska Darnawaty , Venny Venny 
Published: July 2022

The purpose of this research is to analyze the effect of the Debt to Equity Ratio (DER), Gross Profit Margin (GPM), Accounts Receivable Turnover (PP), and Return on Equity (ROE) have on the value of existing companies as Consumer Goods companies on the Indonesia Stock Exchange ( IDX) in 2018-2020. This research will use a quantitative approach. The population is the Consumer Goods sector companies listed on the Indonesia Stock Exchange in 2018-2020, totaling 57 companies. Sampling using purposive sampling method, and resulted in a number of 31 companies. By using analysis technique with multiple linear regression test.The results of this research show that the Debt to Equity Ratio (DER) is not partially affected by the value of consumer goods companies listed on the Indonesia Stock Exchange in 2018 - 2020. Gross Profit Margin (GPM) is partially affected by the value of consumer goods companies listed on the Stock Exchange. Indonesia in 2018 - 2020. Accounts Receivable Turnover (PP) has no partial effect on the value of consumer goods companies listed on the Indonesia Stock Exchange in 2018-2020. Return on Equity (ROE) has no partial effect on the value of consumer companies goods that have been listed on the Indonesia Stock Exchange in 2018-2020. Debt to Equity Ratio, Gross Profit Margin, Accounts Receivable Turnover, and Return on Equity are very influential simultaneously on the value of consumer goods companies listed on the Indonesia Stock Exchange in 2018 - 2020.
Pengaruh Literasi Keuangan Dan Pemanfaatan Financial Technology Terhadap Kepatuhan Pajak Pebisnis Online Yang Dimoderasi Digitalisasi Perpajakan
Authors: Risti Calista Ayu Millenia , Putra Rio Johan 
Published: July 2022

Online businesses have the same activities as conventional businesses, namely managing businesses with the aim of making profits, so online businesses are required to pay taxes as stated in Undang-undang No.7 Tahun 2021 concerning Harmonization of Tax Regulations (HPP). The purpose of this study is to analyze the effect of financial literacy and financial technology utilization on tax compliance which is moderated by tax digitalization on online business owner in Jabodetabek. This study uses a quantitative approach with a associative research design. Data collection in this study was carried out by distributing questionnaires given to 150 people who are online business owner in the Jabodetabek area. The analytical techniques used to answer the hypothesis in this study are multiple linear regression analysis and Moderated Regression Analysis (MRA) test. The analysis result shows that financial literacy has no significant effect on tax compliance, financial technology utilization has a positive and significant effect on tax compliance, tax digitalization is not able to moderate the effect of financial literacy on tax compliance, and tax digitalization is able to moderate by strengthening the influence of financial technology utilization on tax compliance.
Peranan Good Corporate Governance Dan Struktur Kepemilikan Dalam Meminimalisir Biaya Keagenan Pada Perusahaan Manufaktur Di BEI
Authors: Gunawan Andrew 
Published: July 2022

Biaya Agensi menjadi salah satu masalah tersendiri bagi sebagian besar perusahaan, khususnya bagi perusahaan manufaktur. Sejatinya biaya agensi yang timbul dari praktik menyimpang manajemen dapat diminimalisir dengan adanya tata kelola perusahaan yang baik atau yang dikenal dengan good corporate governance. Salah satu bentuk tata kelola yang baik adalah keberadaan dewan komisaris independen yang berfungsi sebagai mekanisme pengawasan yang ada di perusahaan. Selain itu struktur kepemilikan juga memiliki perannya sendiri untuk mengatasi peramsalahan ini. Penelitian ini bertujuan untuk melihat bagaimana peranan good corporate governance dan struktur kepemilikan dalam meminimalisir biaya keagenan di sebuah perusahaan

Keywords: biaya keagenan, good corporate governance , proporsi dewan komisaris independen
Pengaruh Arus Kas, Profitabilitas Dan Leverage Terhadap Financial Distress Saat Masa Pandemi Pada Perusahaan Manufaktur Terdaftar Di BEI
Authors: Dewi Aminar Sutra , Arianto Fajri , Rahim Rida , Winanda Jefri 
Published: July 2022

Financial distress is a condition where a company experiences problems with their finances so that the company is threatened with bankruptcy. This study aims to determine and analyze the effect of cash flow, profitability and leverage variables partially on financial distress, as well as to determine which variable has most dominant influence on financial distress in manufacturing companies. The data processed is secondary data from the annual report of 30 manufacturing companies listed on the IDX in 2016-2021 which were taken through purposive sampling. The method use in this research is panel data regression analysis method using Eviews version 10. The result of this study indicate that : cash flow has a negative effect on financial distress, profitability and leverage have a significant effect on financial distress.

Keywords: Financial distress, cash flow, Profitability, leverage
Analisis pengaruh Financial Literacy dan Locus of Control sebagai variabel moderating terhadap Management Behaviour
Authors: Natan Emawati , Mahastanti Linda 
Published: July 2022

Financial management Behavior needs to be carried out by every individual, including students. However, not all individuals are accustomed to financial management behavior. Financial management behavior in students is thought to be influenced by financial literacy, student locus of control through locus of control as a moderating variable. The purpose of this study was to analyze the effect of financial literacy and locus of control on financial management behavior with locus of control as a moderating variable. Quantitative research is the type of research used. Questionnaires were used as a data collection technique. The total population of the study was 2,338 active undergraduate students. Purposive sampling was used for sampling. Classical assumption test, validity test, reliability test and regression analysis were used as a technique for data analysis and used SPSS 21 software. This study resulted in 1) There is a positive and significant effect of financial literacy on financial management behavior in students. 2) There is a positive and significant influence of locus of control on financial management behavior in students. 3) There is an influence of financial literacy on financial management behavior with locus of control as a moderating variable.
Comparative aspects of experimental models of eye neovascularization of different localization (experimental studies)
Authors: Likhvantseva V. G. , Gevorgyan A. S. , Kapkova S. G. 
Published: July 2022

The evolution of treatment technologies and changing requirements for them dictates the development of a strategy for their implementation in clinical practice. The fi rst stage is the assessment of the capabilities, effectiveness, advantages and disadvantages, the development of indications and contraindications on models of eye diseases in the experiment.The purpose of the work: to conduct a comparative analysis of experimental models of neovascularization of the eyes of different localization, their reproducibility and compliance with natural analogues of human diseases.Material and methods. In an experiment 2 models of chorioretinal neoangiogenesis and 2 models of corneal localization were studied. All models employed the eyes of one biological species of experimental animals – rabbits of the Chinchilla breed (n = 60). Further, the advantages and disadvantages of each of the used models of eye neoangiogenesis were analyzed empirically. The correspondence of the formed experimental models in animals to natural human diseases was checked by fl uorescence angiography, optical coherence tomography and histological research methods. Results. All 4 experimental models demonstrated clinical signs of neovascularization with different clinical manifestations, verifi ed angiographically, morphometrically (OCT models 1 and 2; in vivo) and histologically (models 1–4; ex vivo). The percentage of neovascularization “yield” on different models varied from 75 to 100%. Models of chorioretinal neovascularization were closer in clinical manifestations to the natural manifestations of the neovascular form of age-related macular degeneration. However, anterior localization models were preferred because of the free access, ease of reproduction, and good visualization of the area of interest, allowing monitoring during treatment. At the same time, angiogenesis in these models has a different nature and partly other mechanisms in which infl ammatory reactions play an important role. However, these models make it possible to conduct a comprehensive assessment of the pathological process with a quantitative count of the newly formed vessels in the cornea, including their length, the diameter of their lumen, to assess the usefulness of the anatomy of the vascular wall, the composition and density of the paravasal cell microenvironment. Taken together, this is of no small importance in preclinical trials of technologies with the claimed angiostatic effect.Conclusion. To obtain a full amount of information about the test drug with the declared angiostatic potential, it is necessary to use several models of neoangiogenesis with different mechanisms of pathogenesis, on which one can study the range of their capabilities and side effects, as well as evaluate the entire range of biological effects.
Deep Learning-Based Recognition of Different Thyroid Cancer Categories Using Whole Frozen-Slide Images
Authors: Zhu Xinyi , Chen Cancan , Guo Qiang , Ma Jianhui , Sun Fenglong , Lu Haizhen 
Published: July 2022

Introduction: The pathological rare category of thyroid is a type of lesion with a low incidence rate and is easily misdiagnosed in clinical practice, which directly affects a patient’s treatment decision. However, it has not been adequately investigated to recognize the rare, benign, and malignant categories of thyroid using the deep learning method and recommend the rare to pathologists.Methods: We present an empirical decision tree based on the binary classification results of the patch-based UNet model to predict rare categories and recommend annotated lesion areas to be rereviewed by pathologists.Results: Applying this framework to 1,374 whole-slide images (WSIs) of frozen sections from thyroid lesions, we obtained an area under a curve of 0.946 and 0.986 for the test datasets with and without WSIs, respectively, of rare types. However, the recognition error rate for the rare categories was significantly higher than that for the benign and malignant categories (p &lt; 0.00001). For rare WSIs, the addition of the empirical decision tree obtained a recall rate and precision of 0.882 and 0.498, respectively; the rare types (only 33.4% of all WSIs) were further recommended to be rereviewed by pathologists. Additionally, we demonstrated that the performance of our framework was comparable to that of pathologists in clinical practice for the predicted benign and malignant sections.Conclusion: Our study provides a baseline for the recommendation of the uncertain predicted rare category to pathologists, offering potential feasibility for the improvement of pathologists’ work efficiency.
Boron-Doped Pine-Cone Carbon With 3D Interconnected Porosity for Use as an Anode for Potassium-Ion Batteries With Long Life Cycle
Authors: Lu Jian-Fang , Li Ke-Chun , Lv Xiao-Yan , Kuai Hong-Xiang , Su Jing , Wen Yan-Xuan 
Published: July 2022

Potassium-ion batteries (KIBs) have received widespread attention as an alternative to lithium-ion batteries because of their low cost and abundance of potassium. However, the poor kinetic performance and severe volume changes during charging/discharging due to the large radius of potassium leading to low capacity and rapid decay. Therefore, development of anode materials with sufficient space and active sites for potassium ion deintercalation and desorption is necessary to ensure structural stability and good electrochemical activity. This study prepared boron-doped pine-cone carbon (BZPC) with 3D interconnected hierarchical porous in ZnCl2 molten-salt by calcination under high temperature. The hierarchical porous structure promoted the penetration of the electrolyte, improved charge-carrier diffusion, alleviated volume changes during cycling, and increased the number of micropores available for adsorbing potassium ions. In addition, due to B doping, the BZPC material possessed abundant defects and active centers, and a wide interlayer distance, which enhanced the adsorption of K ions and promoted their intercalation and diffusion. When used as the anode of a KIB, BZPC provided a high reversible capacity (223.8 mAh g−1 at 50 mA g−1), excellent rate performance, and cycling stability (115.9 mAh g−1 after 2000 cycles at 1 A g−1).
Chemical Weathering of the Mekong River Basin With Implication for East Asian Monsoon Evolution During the Late Quaternary: Marine Sediment Records in the Southern South China Sea
Authors: Sang Pham Nhu , Liu Zhifei , Colin Christophe 
Published: July 2022

Clay mineralogy, major-element geochemistry, and Sr-Nd isotopic compositions from Core MD05-2896 collected in the southern South China Sea have been utilized to investigate the discrimination of sediment provenance and to reconstruct a history of chemical weathering in the Mekong River basin over the last 45 ka. The results display that the clay mineral assemblage of the core is characterized by abundant smectite (27%–56%) and illite (18%–32%), with moderate kaolinite (13%–23%) and chlorite (11%–18%), and the 87Sr/86Sr ratio and εNd value narrowly vary in the ranges of 0.7232–0.7272 and from –10.9 to –9.6, respectively. According to clay mineralogy and Sr-Nd isotopic compositions, the Mekong River is the main terrigenous sedimentary source to the southern South China Sea, with no detectable change over the time span of the study, despite having strong sea-level fluctuations. Clay mineralogy and elemental geochemistry analyses reveal that higher smectite/(illite + chlorite), smectite/kaolinite, TiO2/K2O, and SiO2/K2O ratios during Marine Isotope Stage (MIS) 3 and 1 suggest enhanced chemical weathering, whereas lower values of these ratios during MIS 2 indicate weakened chemical weathering. These proxies reveal a close relationship with the available climate records of the East Asian monsoon evolution, implying that the chemical weathering in the Mekong River basin has been strongly controlled by the East Asian monsoon rainfall.
Prognostic Factors of Small Non-Functional Pancreatic Neuroendocrine Tumors and the Risk of Lymph Node Metastasis: A Population-Level Study
Authors: Tan Qingquan , Wang Xing , Li Yichen , Liu Yingyi , Liu Xubao , Ke Nengwen 
Published: July 2022

BackgroundSmall non-functional neuroendocrine tumors (NF-PNETs) are a heterogeneous subset of tumors with controversy regarding their optimal management. We aimed to analyze the prognostic factors of patients with small NF-PNETs and create a risk score for lymph node metastasis (LNM).MethodsData of 751 patients with NF-PNETs ≤ 2 cm were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariate survival analysis was performed to analyze the prognostic factors. Logistic regression was used to identify risk factors for LNM.ResultsOf the 751 patients, 99 (13.2%) were confirmed to have LNM. In multivariate survival analysis, LNM (hazard ratio [HR], 2.12; 95% CI, 1.04–4.32, p = 0.040) was independently associated with disease-specific survival. Logistic regression identified that tumor location in the head of the pancreas (odds ratio [OR], 4.33; 95% CI, 2.75–6.81; p &lt; 0.001), size ≥ 1.5–2 cm (OR, 1.84; 95% CI, 1.17–2.87; p = 0.009), and grade III–IV (OR, 7.90; 95% CI, 1.79–34.90; p = 0.006) were independent risk factors of LNM. According to the OR value, the risk of LNM was scored as follows: a score of 1 for tumors located in the body/tail of the pancreas and 4 for those located in the head; a score of 1 for tumors &lt;1 cm and 2 for those ≥1.5–2 cm; and a score of 1 for tumors with grade I–II and 8 for those with grade III–IV. Finally, the median score for this cohort was 4, with an interquartile range of 3–6. Therefore, patients were classified as three groups based on the risk score system: a total score of 1–3 for low risk, 4–6 for intermediate risk (OR, 2.98; 95% CI, 1.59–5.60; p = 0.001), and 7–14 for high risk (OR, 8.94; 95% CI, 4.50–17.7; p &lt; 0.001), with an incidence of LNM 5.0%, 13.5%, and 31.8%, respectively (p &lt; 0.001).ConclusionSurgical resection with regional lymphadenectomy is recommended for small NF-PNETs with malignant potential of LNM. A risk score for LNM based on tumor grade, location, and size may preoperatively predict LNM of small NF-PNETs and guide clinical practice.
BTN3A2 Expression Is Connected With Favorable Prognosis and High Infiltrating Immune in Lung Adenocarcinoma
Authors: Lin Yuansheng , Zhou Hao , Li Shengjun 
Published: July 2022

Background: Butyrophilin subfamily 3 member A2 (BTN3A2) is an important mediator in immune activation, and it is reported to be linked to many cancer progresses. However, the relation with infiltrating immune and prognosis of BTN3A2 in lung adenocarcinoma are not clear.Methods: In our study, we checked the mRNA expression and protein expression profile of BTN3A2 in lung adenocarcinoma (LUAD) and its relation to clinical outcomes using TIMER and UALCAN databases. In addition, we analyzed the survival of BTN3A2 in LUAD using the Kaplan–Meier Plotter database and PrognoScan database. Moreover, we analyzed gene set enrichment analysis (GSEA) of the BTN3A2. Next, we explored the relation of BTN3A2 expression with the immune infiltration by TIMER. At last, in order to enrich the regulatory mechanism of BTN3A2, we used miRarbase, starbase, and miRDB databases to look for miRNA targets of BTN3A2.Results: The mRNA along with the protein expression of BTN3A2 in the LUAD group was lower than that in the normal group. In addition, high BTN3A2 expression was connected with good first progression (FP) and overall survival (OS) in LUAD. Then, the GSEA analysis demonstrated that T-cell receptor signaling cascade, B-cell receptor signaling cascade, natural killer cell–mediated cytotoxicity, immune receptor activity, immunological synapse, and T-cell activation were enriched differentially in the BTN3A2 high expression phenotype of LUAD. Moreover, BTN3A2 expression is a remarkable positive correlation with invading levels of tumor purity, B cells, neutrophils, CD4+ T cells, dendritic cells, macrophages, and CD8+ T cells in LUAD, and B cells and dendritic cells were linked with a good prognosis of LUAD. To further enrich the possible regulatory mechanisms of BTN3A2, we analyzed the miRNA targets. The results showed that hsa-miR-17-5p may be miRNA targets of BTN3A2.Conclusion: Taking together, we provide evidence of BTN3A2 as possible prognosis biomarkers of LUAD. In addition, high BTN3A2 expression in LUAD may influence the prognosis because of immune invasion. Moreover, our findings provide a potential mechanism that hsa-miR-17-5p may be miRNA targets of BTN3A2.