bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-inflammatory and analgesic effect of an alkaloid-fixed oil mix from Linumusitatisimum seeds in vivo
Authors: Ferhat Riad , Bribi Noureddine , Merakeb Mohamed Sofiane , Betitra Yanat 
Published: February 2022

Inflammation is an immune response to chemical, physical or biological aggression. The comprehension of the several pro-inflammatory and pro-resolving process may lead to the development of new functional drugs instead of the conventional ones. However, Inflammation reaction is conventionally treated by steroidal and nonsteroidal anti-inflammatory drugs. These medications may be useless because of their side effects. In this study, we aim to evaluate the anti-inflammatory and analgesic effect of alkaloid /fixed oil mixture (AO) from flaxseeds in-vivo. Three doses of AO mix (50, 100 and 200 mg/kg) were used in several anti-inflammatory and analgesic tests. The obtained results had shown that the AO mix presents a potential anti-inflammatory and analgesic activities. These results highlight the therapeutic potential of alkaloids and fixed oils combination. Additionally, to other research, the present study supports the anti-inflammatory and analgesic effects of flax seeds with an original contribution by combining alkaloids and fixed oil from Linumusitatissimum
TOLERÂNCIA À SECAGEM E LONGEVIDADE EM SEMENTES DE FLOR DE SEDA (Calotropis procera)
Authors: Colombo Belfort Cristóvam , Nery Eulina Barbosa , Silva Soares Flávia da , Emartino Bezerra Campelo Pedro , Pinho Gomes James , Ribeiro de Lima Thyago 
Published: February 2022

A pesquisa foi realizada no Laboratório de Análise de Sementes da Universidade Federal do Piauí, em Teresina, entre maio de 2018 e julho de 2019, em três ensaios, nos quais avaliaram-se sementes de Flor de Seda quanto à tolerância à secagem e longevidade, em delineamento em blocos ao acaso. O primeiro avaliou o efeito da lavagem na viabilidade de sementes recém colhidas. No segundo ensaio testaram-se a tolerância à secagem em sementes recém colhidas e outras originárias do mesmo lote, de frutos armazenados por um período de 12 meses à temperatura de 5oC. Os tratamentos consistiram de um arranjo fatorial 2 x 6, resultantes dos fatores natureza da semente (armazenadas a baixa temperatura; recém colhidas) e tempo de secagem (0, 12, 24, 36, 48 e 60 horas), tendo como parâmetros a emergência inicial e final (6 e 12 dias). Na longevidade, terceiro ensaio, os tratamentos constaram da amostragem de sementes obtidas sem lavagem, submetidas à secagem ao ar livre, e mantidas sem acondicionamento, analisadas a cada 30 dias, em nove ocasiões, sendo determinados emergência inicial e final. Conclui-se que, a lavagem das sementes melhora a emergência e, armazenadas a 5oC por doze meses, perdem a viabilidade. Mais de 12 horas de secagem reduz o teor de umidade em 50% nas sementes recém colhidas e 94% nas armazenadas. A secagem por 60 horas, reduz a emergência total em 36%, comprometendo o vigor das sementes. Estima-se a longevidade em 180 dias.
CARACTERIZAÇÃO FÍSICO-QUÍMICA DA CACHAÇA ARTESANAL COMERCIALIZADA NO MERCADO MUNICIPAL DE CORONEL MURTA-MG
Authors: Gama Ednilton Moreira 
Published: February 2022

O termo cachaça é utilizado para designar o destilado da cana-de-açúcar produzido exclusivamente no Brasil, cuja graduação alcoólica varia de 38 a 48 % vol. Essa bebida produzida em alambiques de cobre apresenta melhor qualidade sensorial quando comparada à produzida em alambiques confeccionados com outros materiais, como aço inox, alumínio e porcelana. Durante o seu processo de produção pode surgir contaminantes e substâncias indesejáveis que podem afetar a qualidade da bebida. Assim, o presente trabalho objetiva realizar análises físico-químicas, tais como graduação alcoólica, pH e quantificação de cobre em cinco amostras de cachaças artesanais comercializadas na cidade de Coronel Murta-MG. A graduação alcoólica foi determinada utilizando-se o método densimétrico e a concentração de cobre foi determinada através de método espectrofotométrico UV-Vis. Os resultados foram comparados com os valores estabelecidos pela Instrução Normativa N° 13/2005. Com relação ao parâmetro pH as amostras apresentaram valores concordantes com a legislação, variando de 3,9 a 5,3. As amostras apresentaram teor alcoólico de 38,0 a 41,0 %vol, em conformidade com os valores estabelecidos pela legislação. A concentração de cobre apresentou resultado que variou de 1,63 ± 1,04 a 4,96 ± 1,04 mg L-1, condizentes com a legislação brasileira. O trabalho proposto possui potencial de aplicação na região para monitoramento da qualidade em relação ao contaminante cobre, permitindo uma rápida atuação dos produtores, a fim de corrigir desvios detectados.
Effect of Cadmium Exposure on the Potential for Impaired Kidney Function on the Manual Car Painting Industry
Authors: Susetyo Septian Hadi , Oginawati Katharina , Utami Rosetyati Retno 
Published: February 2022

This study aimed to assess the risk of cadmium (Cd) exposure from the car painting process against urinary cadmium levels (UCd) and urinary albumin (UAlb) in workers, which is one of the biomarkers of decreased kidney function. The research was conducted in the informal car painting industry in Bandung, with a cross-sectional method. This study used 60 respondents, 30 respondents as workers’ exposure, and 30 respondents as a control. Measurements of Cd exposure conducted using a personal sampling pump were equipped with PVC filter, which was placed on workers’ collar then analysed using AAS method. The measurements of UCd and UAlb carried out using urine sample 20 - 50 mL after day work. UCd analysis using UV-Visible Spectrophotometer and UAlb using the immunoturbidimetry method. This study’s results were 15 of 30 workers above the TLV-TWA from ACGIH, with a mean value of TWA was 2.043 µg/m3 for the exposed group and 0.135 µg/m3 for the control group. For UCd in the exposed group, the mean UCd was 0.028 µg/g creatinine and 0.003 µg/g creatinine in controls. The UAlb mean was 19.1 µg/mg creatinine for the painter group and 4.26 µg/mg creatinine on controls. The results of the analysis show that there are significant differences between the control group and the workers. It can be concluded that there has been a biomarker in the kidney so that it has a great potential in decreasing kidney function.
HIGHLIGHTS

Cadmium exposure of workers in the car painting industry has been assessed
Urinary cadmium (UCd) and urinary albumin (UAlb) levels in workers have been discussed
The occurrence of Biomarkers of Cadmium exposure has been discussed

GRAPHICAL ABSTRACT
Maintaining Growth of Aquatic Morning Glory under Drought Condition by Paenibacillus sp. BSR1-1
Authors: Somtrakoon Khanitta , Sangdee Aphidech , Chouychai Waraporn 
Published: February 2022

Paenibacillus sp. BSR1-1 is a plant growth-promoting bacteria with the ability to produce indole-3-acetic acid, exopolysaccharide and ammonia. This bacterial isolate grew well under low water potential, with the concentration of polyethylene glycol (PEG) ranging from 20 - 30 % (w/v). Paenibacillus sp. BSR1-1 was a suitable bio-inoculant to maintain the growth of aquatic morning glory cultivated under drought conditions in this study. Inoculation of Paenibacillus sp. BSR1-1, as immobilized cells in coconut husk, sawdust or rice straw, tended to stimulate root growth of aquatic morning glory cultivated under drought conditions. The specific root lengths of aquatic morning glory grown under drought conditions were 1.31, 2.86, and 1.76 m/g in the presence of Paenibacillus sp. BSR1-1 immobilized in coconut husk, sawdust or rice straw, respectively. Root length and root dry weight of aquatic morning glory planted under drought conditions in the presence of Paenibacillus sp. BSR1-1 were around 17.71 - 18.08 cm and 0.16 - 0.28 g, respectively. Meanwhile, the root length and root dry weight of aquatic morning glory planted under drought conditions in the absence of Paenibacillus sp. BSR1-1 were only 10.62 - 13.54 cm and 0.04 - 0.11 g, respectively. In addition, the root morphology of aquatic morning glory planted under drought conditions in the presence of Paenibacillus sp. BSR1-1 was more branched and longer than that without Paenibacillus sp. BSR1-1 inoculation. However, the inoculation of Paenibacillus sp. BSR1-1 to soil did not stimulate shoot growth of aquatic morning glory planted under both normal and drought conditions.
HIGHLIGHTS

Paenibacillus BSR1-1 is a plant growth-promoting bacteria with the ability to produce indole-3-acetic acid (IAA), exopolysaccharides and enables growth at a low water potential
Application of Paenibacillus BSR1-1 as a bio-inoculant tended to maintain the growth of aquatic morning glory under drought conditions
The root morphology of aquatic morning glory planted under drought conditions in the presence of Paenibacillus BSR1-1 was more branched and longer than that without bacterial inoculation

GRAPHICAL ABSTRACT
Heat Pump Design for Simultaneous Cooling Space and Heating Water Coupled with Earth-Tube Heat Exchanger as Secondary Heat Sink
Authors: Arunwattana Weerawoot 
Published: February 2022

A heat pump for simultaneous heating and cooling (HPS) is more efficient in energy and beneficial
in use than a reversible heat pump which works in either direction to provide heating or cooling. A HPS is usually coupled with a thermal storage tank for possibly operating in 3 modes: heating mode, cooling mode, and simultaneous heating and cooling mode. To improve the HPS performance in heating mode or cooling mode, the HPS should be installed an auxiliary equipment in order to reject overheat in the system or to absorb supplemental heat into the system. This paper proposed a design of a HPS for cooling space and hot water production coupled with a horizontally shallow earth-tube heat exchanger as secondary heat sink for Thai residences in which the main components in the design are composed of the condenser and the earth tube heat exchanger. The coefficients of performance (COP) of the HPS were evaluated by the experiments. The results showed that it could work the best performance when it worked in simultaneous cooling and heating mode at the water flow rate of 6.0 L/min with the coefficient of performance (COP) of 6.3±3.1 %. The HPS had high efficiency and it worked continuously in cooling mode when it operated in the nighttime with the average COP of 4.3±14.5 %. However, an efficiency of the HPS was declined when heat gain in the conditioned room is significantly increased by high intensity of solar radiation in the daytime with the average COP of 2.5±14.5 %.
HIGHLIGHTS

Energy used for cooling or heating systems such as air-conditioning and hot water production is predominantly effect to total energy use in residential sector in many countries including Thailand
A heat pump for simultaneous heating and cooling (HPS) for cooling space and hot water production coupled with thermal storage tank and a horizontally shallow earth-tube heat exchanger as secondary heat sink were designed for Thai residences
This HPS could work the best performance when it worked in simultaneous cooling and heating mode
For only cooling mode, this HPS worked continuously with high performance when it operated in the nighttime but in the daytime it still worked continuously with lower performance

GRAPHICAL ABSTRACT
Novel Development of Corrosion Resistant Paint Using Printed Circuit Board from Modern Electronic Wastes
Authors: Rajendran Mohana , Giftlin Marto 
Published: February 2022

The growth in the industrial technology and communication sectors has enhanced the usage of electronic gadgets exponentially. Thus, it becomes highly essential to find new solution to utilize or dispose these e-wastes, in order to reduce the e-waste generation. Various reports mentioned that the major component of these e-wastes is their Printed Circuit Boards. Therefore, a new ideology is proposed to use these boards to produce a new coating with good corrosion resistance. At first the boards were separated from the discarded electronic appliances and various electrical elements were separated from these boards. Then the plain circuit boards are pulverized into fine particles and mixed with paint in 3 different proportions ranging from 1:4 to 1:2. The resulting mix was applied over the steel specimen and tested for corrosion resistance. The assessment was done in the aspects of contact angle, weight loss percentage, potentio dynamic polarization technique and electro chemical impedance spectroscopy. From the results it was clear that increase in the addition of printed circuit powder content in the corrosion proof paint coating enhanced the efficiency of the corrosion resistant behaviour 3.5 times than the specimen with uncoated steel specimens. This development of corrosion resistant behaviour of printed circuit powder was attributed from the inertness offered by the presence of silicon dioxides towards the corrosive fluids. Although, the coating of 1:2 proved to be optimum to protect the steel elements from the aggressive corrosion environment, by considering the workability aspects the 1:3 combination was suggested for the innovative development of anti-corrosion paint coating from the e-waste resources.
HIGHLIGHTS

Life cycles of every electronic wastes end with the hazardous challenging disposals
Innovative utilizations of these electronic wastes for the corrosion resistant structural applications were detailed
An anti corrosive coating for steel reinforcement was developed from the waste printed circuit boards
Coating by printed circuit board powder enhanced 3.5 times more protection from the corrosion

GRAPHICAL ABSTRACT
Improving Competency in Safe Patient Handling Through Online Learning Beyond the Classroom: A Longitudinal Study
Authors: Webb Jo , Hogg Peter , Twiste Martin , Correa Elon 
Published: February 2022

Abstract
Importance: Safe patient handling is intrinsic in health care provision, yet education in the skills required for safe patient handling is inconsistently delivered, with limited evidence that traditional face-to-face training reduces risk.
Objective: To assess the long-term effectiveness of replacing annual practical handling updates with an online training system, combined with competency assessment of skill and safety.
Design: Quasi-experimental longitudinal 3-yr study to track practical people handling skill development among undergraduate occupational therapy students. All participants had access to a multimedia online training system (that replaced tutor-led practical training), used in combination with annual competency evaluations to measure skills and safety in four people handling tasks.
Setting: All competency assessment took place on site in the School of Health and Society, University of Salford (Salford, United Kingdom).
Participants: Undergraduate BSc(Hons) occupational therapy students (N = 243).
Outcomes and Measures: Participants attended individual 45-min competency evaluations at three data collection points: beginning of Years 2 and 3 and end of Year 3. Data were collected by trained assessors using a competency assessment tool.
Results: Results demonstrate significant increases in skill level for sit-to-stand and repositioning in the chair (p &lt; .05) and for hoisting and slide sheet maneuvers (p &lt; .0001). Participants achieved 100% safety scores for repositioning in the chair and hoisting.
Conclusions and Relevance: Students using the online system performed significantly better than students receiving traditional annual practical updates, providing an evidence base to reduce tutor-led training hours while increasing skill and safety levels using a combination of the online system and competency assessment.
What This Article Adds: This approach was found to reinforce safe handling techniques and increase independence, competency, and safety of service users and caregivers working in health and social care environments while reducing time spent delivering annual people handling updates. The findings support replacement of face-to-face training updates, particularly in the current climate of social distancing.
Psychometric Properties of the Little Developmental Coordination Disorder Questionnaire–Taiwan
Authors: Fu Chung-Pei , Tseng Mei-Hui , Cermak Sharon , Chung Tzu-Han , Chen Yu-Lan , Lu Lu , Shieh Jeng-Yi , Rihtman Tanya 
Published: February 2022

Abstract
Importance: Early identification of young children at risk of developmental coordination disorder (DCD) can support early intervention and prevent secondary sequelae.
Objective: To examine the psychometric properties of a translated and cross-culturally adapted version of the Little Developmental Coordination Disorder Questionnaire–Taiwan (LDCDQ–TW).
Design: Prospective study.
Setting: Kindergartens and preschools in north, central, and south Taiwan.
Participants: In Phase 1 the participants were 1,124 parents of typically developing children ages 36–71 mo. Children with confirmed developmental diagnoses were excluded. Participants in Phase 3 were 162 children who had been recruited in Phase 2.
Outcomes and Measures: The LDCDQ–TW, a 15-item parent questionnaire for identifying children at risk for DCD, and the Movement Assessment Battery for Children (2nd ed.; MABC–2), were administered.
Results: The findings revealed excellent test–retest reliability (intraclass correlation coefficient [ICC] = .97) and poor interrater reliability (ICC = .47). On the basis of MABC–2 scores, the non-DCD group (≥15th percentile) scored significantly higher than the DCD and suspect-DCD groups on the LDCDQ–TW, but the latter two groups did not differ from one another. Using the 15th percentile as a cutoff for both the MABC–2 and the LDCDQ–TW, sensitivity was .96 and specificity was .68.
Conclusions and Relevance: Although standardized performance-based assessments are required to confirm a diagnosis of DCD (typically after age 5 yr), the LDCDQ–TW demonstrated sound reliability and validity and can support the early identification of young children at risk of DCD in Taiwan.
What This Article Adds: The LDCDQ–TW can facilitate early intervention for DCD and prevent secondary sequelae, improving outcomes for children with DCD.
Treatment adherence and effect of concurrent statin intensity on the efficacy and safety of alirocumab in a real-life setting: results from ODYSSEY APPRISE
Authors: Banach Maciej , López-Sendon José Luis , Averna Maurizio , Cariou Bertrand , Loy Megan , Manvelian Garen , Batsu Isabela , Poulouin Yann , Gaudet Daniel 
Published: February 2022

IntroductionThe phase IIIb open-label ODYSSEY APPRISE study prospectively assessed the safety and efficacy of alirocumab (a proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitor) in a real-life setting in high cardiovascular risk patients with heterozygous familial hypercholesterolemia or low-density lipoprotein cholesterol (LDL-C) not at goal despite maximally tolerated dose statins ± other lipid-lowering therapies (NCT02476006). This post-hoc analysis assessed patient adherence to statins and alirocumab, plus alirocumab efficacy and safety, according to concomitant statin intensity and prior ezetimibe usage.Material and methodsPatients received alirocumab 75 or 150 mg (dose adjustment based on physician’s judgment) every 2 weeks (for ≥3 to ≤30 months).ResultsOf 994 enrolled and treated patients, 58.4% received concomitant high-intensity statins, 18.2% moderate/low-intensity statins, and 23.4% no statin; 55.9% received prior ezetimibe. Mean alirocumab adherence (percent adherence defined as injections received ÷ theoretical injections x 100) was 96.6% over 72.4 weeks’ mean treatment duration. Mean LDL-C reduction from baseline at Week 12 was similar between statin intensity subgroups (53.6–55.7%). More patients achieved LDL-C <1.8 mmol/L and/or ≥50% reduction from baseline in the ≥100% versus <100% adherent to alirocumab subgroup; high-intensity and low/moderate-intensity subgroups versus no statin subgroup; and prior ezetimibe versus no prior ezetimibe subgroup. Treatment-emergent adverse events occurred in 65.2–75.1% and 68.0–76.3% of patients across statin and ezetimibe subgroups, respectively.ConclusionsIn a real-life setting, patient adherence to alirocumab was high. Alirocumab provided clinically significant reductions in LDL-C, with most patients achieving LDL-C treatment targets across background statin therapy and prior ezetimibe therapy subgroups.
Biochemical and cardiovascular predictors of PIMS-TS risk in children after COVID-19 recovery: preliminary results of the LATE-COVID-Kids Study
Authors: Jatczak-Pawlik Izabela , Lewek Joanna , Czkwianianc Elżbieta , Blomberg Agnieszka , Krysiak Natalia , Zeman Krzysztof , Jankowski Piotr , Banach Maciej 
Published: February 2022

IntroductionWe aimed to characterize biochemical and cardiovascular predictors of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) risk based on the data from the LATE-COVID-Kids study.Material and methods148 consecutive COVID-19 convalescents hospitalized for the clinical evaluation after the acute phase of COVID-19 were classified into two groups related to symptoms: 33 children finally diagnosed with PIMS-TS and 115 children without PIMS-TS (control group).ResultsPIMS-TS children were significantly younger (6.79 ±4.57 vs. 9.10 ±4.94 years). After adjustment, in comparison to those without, PIMS-TS children had a higher level of antithrombin III (111 ±9.30 vs. 105 ±11.4), higher heart rate (HR)/min (100 (89.0–111) vs. 90 (79.7–100)) and sinus rhythm (p = 0.03) but lower PQ interval (p = 0.02) on admission to hospital. The lymphocytes (absolute count and percentage) were significantly higher in children with PIMS-TS, and the opposite results were obtained for IgA and neutrophils. Furthermore, children with PIMS-TS had a higher level of thyroid stimulating hormone (2.76 (2.16–4.18) vs. 2.36 (1.73–2.83)) and red cell distribution width (p < 0.005) compared to those without.ConclusionsIt is the first data on the possible predictors of PIMS-TS risk in the Long-COVID period. These results need to be further validated to next create the PIMS SCORE algorithm, which might enable the effective prediction of children with the risk of PIMS-TS occurrence after COVID-19 recovery.
Trientine Hydrochloride (Waymade-Trientine)
Authors: Reimbursement Team  
Published: February 2022

CADTH recommends that Waymade-Trientine should be reimbursed by public drug plans for the treatment of patients with Wilson disease if certain conditions are met.
Waymade-Trientine should only be covered to treat patients who have previously tried and demonstrated intolerance to d-penicillamine (DPA).
Waymade-Trientine should only be reimbursed if initiated by clinicians experienced in the management of Wilson disease and if the cost of Waymade-Trientine is reduced.
AS CONTRIBUIÇÕES DA TERAPIA COGNITIVO COMPORTAMENTAL NA PSICOLOGIA JURÍDICA: VARAS DE FAMÍLIA
Authors: Mesquita Kalma Souza de , Cerqueira Gustavo Luis Caribé 
Published: February 2022

Este artigo teve como objetivo geral, em revisão narrativa, em corte transversal, investigar e mapear as contribuições da terapia cognitivo comportamental na psicologia jurídica - varas de família. Bem como, verificar a viabilidade da aplicação da Terapia Cognitivo Comportamental na psicologia jurídica - varas de família; analisar as etapas da conduta psicológica, frente às demandas na psicologia jurídica nas varas de família; e, observar o andamento técnico na tomada de decisões. Foi utilizado procedimento (revisão ou levantamento) bibliográfico para elaboração e desenvolvimento dessa obra. Teve como assuntos analisados a Terapia Cognitivo Comportamental, a Psicologia jurídica, as varas de família, a Alienação Parental e as principais Técnicas científicas de coleta de dados. O objetivo proposto foi alcançado satisfatoriamente, haja vista, a psicologia jurídica como um todo e sua pretensão principal, auxiliar o melhor exercício do direito e o seu compromisso com o protagonismo humano em diferentes contextos que ela beneficia. Tudo são trocas de esclarecimentos e saberes, uma vez que, objetiva contribuir e corresponder, humanitariamente, à questão do bem-estar familiar e social.