bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Electronic Patient-Reported Outcomes Tool for Older Adults With Complex Chronic Conditions: Cost-Utility Analysis
Authors: Miranda Rafael N , Bhuiya Aunima R , Thraya Zak , Hancock-Howard Rebecca , Chan Brian CF , Steele Gray Carolyn , Wodchis Walter P , Thavorn Kednapa 
Published: April 2022

Background
eHealth technologies for self-management can improve quality of life, but little is known about whether the benefits gained outweigh their costs. The electronic patient-reported outcome (ePRO) mobile app and portal system supports patients with multiple chronic conditions to collaborate with primary health care providers to set and monitor health-related goals.

Objective
This study aims to estimate the cost of ePRO and the cost utility of the ePRO intervention compared with usual care provided to patients with multiple chronic conditions and complex needs living in the community, from the perspective of the publicly funded health care payer in Ontario, Canada.

Methods
We developed a decision tree model to estimate the incremental cost per quality-adjusted life year (QALY) gained for the ePRO tool versus usual care over a time horizon of 15 months. Resource utilization and effectiveness of the ePRO tool were drawn from a randomized clinical trial with 6 family health teams involving 45 participants. Unit costs associated with health care utilization (adjusted to 2020 Canadian dollars) were drawn from literature and publicly available sources. A series of sensitivity analyses were conducted to assess the robustness of the findings.

Results
The total cost of the ePRO tool was CAD $79,467 (~US $ 63,581; CAD $1733 [~US $1386] per person). Compared with standard care, the ePRO intervention was associated with higher costs (CAD $1710 [~US $1368]) and fewer QALYs (–0.03). The findings were consistent with the clinical evidence, suggesting no statistical difference in health-related quality of life between ePRO and usual care groups. However, the tool would be considered a cost-effective option if it could improve by at least 0.03 QALYs. The probability that the ePRO is cost-effective was 17.3% at a willingness-to-pay (WTP) threshold of CAD $50,000 (~US $40,000)/QALY.

Conclusions
The ePRO tool is not a cost-effective technology at the commonly used WTP value of CAD $50,000 (~US $40,000)/QALY, but long-term and the societal impacts of ePRO were not included in this analysis. Further research is needed to better understand its impact on long-term outcomes and in real-world settings. The present findings add to the growing evidence about eHealth interventions’ capacity to respond to complex aging populations within finite-resourced health systems.

Trial Registration
ClinicalTrials.gov NCT02917954; https://clinicaltrials.gov/ct2/show/NCT02917954
Impact of a Mobile Application for Tracking Nausea and Vomiting During Pregnancy (NVP) on NVP Symptoms, Quality of Life, and Decisional Conflict Regarding NVP Treatments: MinSafeStart Randomized Controlled Trial
Authors: Ngo Elin , Truong Maria Bich-Thuy , Wright David , Nordeng Hedvig 
Published: April 2022

Background
Pregnant women are active users of mobile apps for health purposes. These apps may improve self-management of health-related conditions. Up to 70% of pregnant women experience nausea and vomiting (NVP). Even mild NVP can significantly reduce quality of life (QoL), and it can become an economic burden for both the woman and society. NVP often occurs before the first maternal care visit; therefore, apps can potentially play an important role in empowering pregnant women to recognize, manage, and seek appropriate treatment for NVP, when required.

Objective
This study investigated whether the MinSafeStart (MSS) mobile app could impact NVP-related symptoms, QoL, and decisional conflict regarding NVP treatment.

Methods
This randomized controlled trial enrolled 268 pregnant women with NVP in Norway from 2019 to 2020. The intervention group had access to the MSS app, which could be used to track NVP symptoms and access tailored advice. NVP severity was rated with the Pregnancy Unique Quantification of Emesis (PUQE) score. The control group followed standard maternal care. We collected data on maternal baseline characteristics, NVP severity, QoL, and decisional conflict using 2 sets of online questionnaires. One set of questionnaires was completed at enrollment, and the other was completed after 2 weeks. We performed linear regression analyses to explore whether the use of the MSS app was associated with NVP severity, QoL, or decisional conflict.

Results
Among the 268 women enrolled in the study, 192 (86.5%) completed the baseline questionnaires and were randomized to either the intervention (n=89) or control group (n=103). In the intervention group, 88 women downloaded the app, and 468 logs were recorded. In both groups, women were enrolled at a median of 8 gestational weeks. At baseline, the average PUQE scores were 4.9 and 4.7; the average QoL scores were 146 and 149; and the average DCS scores were 40 and 43 in the intervention and control groups, respectively. The app had no impact on NVP severity (aβ 0.6, 95% Cl −0.1 to 1.2), QoL (aβ −5.3, 95% Cl −12.5 to 1.9), or decisional conflict regarding NVP treatment (aβ −1.1, 95% Cl −6.2 to 4.2), compared with standard care.

Conclusions
Tracking NVP symptoms with the MSS app was not associated with improvements in NVP symptoms, QoL, or decisional conflict after 2 weeks, compared with standard care. Future studies should include a process evaluation to improve our understanding of how pregnant women use the app and how to optimize its utility within maternity care. Specifically, studies should focus on how digital tools might facilitate counseling and communication between pregnant women and health care providers regarding NVP management during pregnancy.

Trial Registration
ClinicalTrails.gov (NCT04719286): https://www.clinicaltrials.gov/ct2/show/NCT04719286
Effect of Explant Types and Benzyl Amino Purine Concentrations on the In Vitro Regeneration of Several Local Eggplant Cultivars
Authors: Erniwitama Erniwitama , Taryono Taryono , Murti Rudi Hari 
Published: April 2022

Eggplant as a vegetable is generally fresh consumed. Besides having a high nutritive value, eggplant contains solasonine and solamargine, which act as an antibacterial that can inhibit cancer cells, gastrictic and respiratory disorders. Eggplant also provides a unique system to study in vitro regeneration since it can be induced from different explants by different growth regulators and morphogenetic pathways. This study aims to observe the effect of explant types and BAP concentrations on the in vitro regeneration of three eggplant cultivars, Rimbang, Tanteloh and Limao. Leaf and hypocotyl explants were cultured on MS semi solid medium supplemented with BAP and IBA in combination. BAP tested at 1, 2 and 3 mgL-1 while IBA tested at 1 mgL-1. Medium containing 1 mgL-1 IBA used for rooting of regenerated shoot. The experiment was arranged in completely randomized design with five replicates. Each replicate consisted of five leaves and hypocotyl explants. Cultures were incubated at 25±10C, 65% humidity, and 16 hours per day photoperiod. Observation was done for 8 weeks of culture. The result indicated that leaf explants showed shoot initiation within 5 – 9 days of cultured, while hypocotyl explants showed the response within 7 – 12 days of cultured. Shoots formation preceded by swollen on the explants surface followed by emerging light green shoot. Leaf explants cultured on medium supplemented with 3 mgL-1 BAP + 1 mgL-1 IBA showed the maximum number of shoots regeneration while hypocotyl explants showed less of shoots in all medium. Similarly, leaf explants cultured on medium supplemented with 3 mgL-1 BAP + 1 mgL-1 IBA showed the maximum number of roots. Among the cultivars, Rimbang showed the best response than other cultivars.
Pengaruh Aerasi dan Kadar Air Awal terhadap Kinerja Pengomposan Kotoran Sapi Sistem Windrow
Authors: Hapsari Umi 
Published: April 2022

AbstractThis study aims to determine the effect of material composition and initial moisture content on composting performance on active and passive aeration with a pile system. The parameters observed were changes in temperature, pH, moisture content, degradation of organic matter and germination. The treatment in this study is composting with different initial moisture content and closed windrow conditions. There are 3 variations of the mixture of ingredients. Variation A mixture of cow dung with sawdust is given active aeration. Variation B mixture of cow manure with vegetable waste is given active aeration. Variation C mix cow dung with passive EM4 aeration. The optimal initial moisture content for composting is 50 - 60%. Open windrow conditions during the composting process result in a high percentage of water content reduction and heat loss occurring in the pile. The degree of acidity (pH) of composting for each treatment shows an acceptable pH range of 8 - 9. The degradation of organic matter is related to the high composting temperature the higher the composting temperature the higher the microbial activity so that the process of degradation of organic matter is faster. AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh komposisi bahan dan kadar air awal terhadap kinerja pengomposan pada aerasi aktif dan pasif dengan sistem tumpukan. Parameter yang diamati adalah perubahan suhu, pH, kadar air, degradasi bahan organik dan perkecambahan. Perlakuan dalam penelitian ini adalah pengomposan dengan kadar air awal berbeda dan kondisi tumpukan (windrow) tertutup. Terdapat 3 variasi campuran bahan. Variasi A campuran kotoran sapi dengan serbuk gergaji diberi aerasi aktif. Variasi B campuran kotoran sapi dengan limbah sayur diberi aerasi aktif. Variasi C campuran kotoran sapi dengan EM4 aerasi pasif. Kadar air awal yang optimal untuk pengomposan adalah 50 – 60%. Kondisi tumpukan (windrow) yang terbuka selama proses pengomposan mengakibatkan persentase penurunan kadar air yang tinggi dan diikuti terjadinya panas hilang pada tumpukan. Derajat keasaman (pH) pengomposan untuk masing – masing perlakuan menunjukan rentang pH yang dapat diterima yaitu 8 – 9. Degradasi bahan organik berhubungan dengan suhu pengomposan yang tinggi semakin tinggi suhu pengomposan maka aktivitas mikrobia semakin tinggi sehingga proses degradasi bahan organik semakin cepat.
TENDÊNCIA DAS INTERNAÇÕES POR QUEDAS DE IDOSOS NO SISTEMA PÚBLICO DE SAÚDE, PIAUÍ, 2010-2018
Authors: Melo Neto Antonio Quaresma de , Oliveira Elton Filipe Pinheiro de , Mascarenhas Márcio Dênis Medeiros , Rodrigues Malvina Thais Pacheco 
Published: April 2022

A partir dos 60 anos de vida, as chances de quedas aumentam significativamente. Estima-se que 30% dos idosos comunitários caem a cada ano, e metade desses de forma recorrente. O objetivo deste estudo foi analisar a tendência das internações hospitalares por quedas de idosos no Piauí, no período de 2010 a 2018. Trata-se de um estudo de séries temporais com dados do Sistema de Informações Hospitalares do Sistema Único de Saúde. Utilizou-se o modelo de regressão linear de Prais-Winsten para análise de tendência. Ocorreram 14.286 internações por quedas de idosos, com maior ocorrência no sexo feminino (62%), na faixa de 60 a 69 anos (37,1%), sem especificação sobre o tipo de queda (73,6%). Observou-se tendência crescente na taxa de internação hospitalar para o sexo feminino (variação percentual anual – APC = 10,5% – IC95% 6,6; 14,4) e por quedas de um nível ao outro (APC = 10,6 – IC95% 0,6; 21,7). O coeficiente de letalidade apresentou tendência crescente para quedas ocorridas no mesmo nível (APC = 16,7 – IC95% 9,2; 24,8). Conclui-se que tanto a internação quanto a letalidade hospitalar por quedas de um nível a outro e do mesmo nível apresentaram tendência de aumento. Maior permanência e letalidade hospitalar foi observada nas regionais de saúde Cocais e Carnaubais.
À MESA COM LUTERO
Authors: Beling Éder 
Published: April 2022

Neste artigo abordaremos em especial o período da Reforma, sobretudo as recomendações de Lutero sobre o culto cristão e a prática da pregação. Analisa-se a compreensão de Lutero sobre o culto. A seguir, enfocam-se passagens nas quais ele oferece exemplos e sugestões de como deveria ocorrer a pregação. Tais exemplos são tirados, em sua grande maioria, de suas Conversas à mesa (Tischreden). Quer-se analisar alguns pontos do pensamento de Lutero em relação aos desafios práticos que ele sentia quando pregava. Por serem a Bíblia e a Palavra de Deus centrais para o protestantismo, faz-se pertinente a pesquisa sobre a forma como Lutero abordava e compreendia a pregação desde o seu contexto prático. Nas Conversas à mesa, ele demonstra sua alegria, faz recomendações, sente-se triste e dialoga sobre a pregação cristã, desde o seu conteúdo até a forma como ela era realizada. Esta é uma pesquisa bibliográfica.
Differential requirements for Rhubarb in constipation-induced inflammation, disorder of gut microbiome and metabolism
Authors: Gao Han , He Chengwei , Hua Rongxuan , Wang Boya , Du Yixuan , Liang Chen , Guo Yuexin , Gao Lei , Zhang Lucia , Shang Hongwei , Xu Jingdong 
Published: April 2022

Background: Although constipation is a common syndrome and a worldwide
health problem, the mechanism of underlying remission remains poorly
understood. Patients with constipation are becoming younger with a
29.6% overall prevalence in the children, which has captured great
attention of scientists because of its epigenetic rejuvenation and
recurrent episodes. Despite the usage of rhubarb torelieveconstipation,
novel targets and genes involved in target-relevant pathways with
remarkable functionalities should still be sought after. Materials and
methods: We established a reliable constipation model in C57B/6N male
mice using intragastric administration diphenoxylate and the eligible
subjects received rhubarb extraction at a dose of 600mg/25g for three
days to ameliorate constipation. Resultant constipation was
morphological and genetically compared to the different group’s
specimen. Results: The constipation mice exhibited thicker muscle
layers, improved content of cytokines, including IL-17 and IL-23, and
lower content of IL-22. Afterward, the bacterial abundance and diversity
varied tremendously. Additionally, SCFA and MLCFA were significantly
influenced by the constipation condition accompanied by the enhanced
expressions of SCFA receptors, GPR41 and GPR43. Nevertheless, the
alterations were reversed to the normal level when constipation mice
were treated with rhubarb. Conclusion: This thesis has provided a deeper
insight into the confirmation that rhubarb promoted the flexibility of
collagen fiber, reduced pro-inflammatory cytokines and enhanced
anti-inflammatory cytokines to relieve inflammation, improved intestinal
barrier function and maintained intestinal microflora balance, with
potential effects on intestinal microenvironment such as affecting the
metabolism of fatty acids and polyamines.
Putins värsta fiende: Aleksej Navalnyj och hans anhängare
Authors: Sangadzhieva Inna 
Published: April 2022

Aleksei Navalnyj har blitt en politiker av føderal størrelse, som våget å sette Vladimir Putins posisjon som Russlands øverste leder i tvil. Gjennom en etablering av horisontale antikorrupsjonsnettverk over hele landet, har Navalnyj forsøkt å returnere politikken tilbake til samfunnet. Kalle Kniviläs bok Putins verste fiende følger FSB jakten på Aleksej Navalnyj og er en viktig beretning om forholdet mellom liv og død, mellom redsel og mot, og mellom et fritt og et fanget menneske.
Alexey Navalny has become a politician of federal calibre, the man who dared to question Vladimir Putin’s position as the head of Russia. By establishing a horizontal anti-corruption network over the entire country, Navalny sought to return politics back to the people. Kalle Knivilä’s Putins verste fiende (Putin’s Worst Enemy) traces how the Federal Security Service (FSB) has dogged Navalny’s every step. This is an important story of the relationship between life and death, fear and courage, and between a free individual and a trapped person.
PERBEDAAN TINGKAT PENGETAHUAN DAN SIKAP PENCEGAHAN RABIES ANTARA WISATAWAN ASING DAN WISATAWAN DOMESTIK DI KAWASAN ITDC NUSA DUA
Authors: Sumaryani Desak Putu Yuni , Damayanti Putu Ayu Asri , Sanjiwani Ida Arimurti 
Published: April 2022

Bali merupakan daerah wisata yang masih endemis rabies. Wisatawan harus memiliki pengetahuan dan sikap pencegahan yang baik untuk menurunkan risiko terkena rabies. Penelitian ini bertujuan untuk mengetahui perbedaan tingkat pengetahuan dan sikap pencegahan wisatawan asing dan domestik terhadap penyakit rabies di ITDC Nusa Dua. Penelitian ini merupakan penelitian kuantitatif, jenis penelitian deskriptif komparatif dengan pendekatan cross sectional. Sampel pada penelitian diambil di Kawasan ITDC Nusa Dua dengan menggunakan teknik accidental sampling sehingga di peroleh sampel sebanyak 40 wisatawan asing dan 40 wisatawan domestik. Pengumpulan data dilakukan dengan menggunakan kuisioner untuk mengetahui data demografi, tingkat pengetahuan dan sikap pencegahan. Hasil penelitian didapatkan pengetahuan wisatawan asing yang dikategorikan baik (72,5%), cukup (25,0%), dan kurang (2,5%) sedangkan wisatawan domestik di kategorikan baik (70,%), cukup (250%) dan kurang (5%) serta sikap pencegahan wisatawan asing dikategorikan baik (10,%), cukup (77,5%), kurang (12,5%) dan wisatawan domestik dikategorikan baik (5%), cukup (95%). Hasil uji statistic menunjukkan tidak terdapat perbedaan tingkat pengetahuan wisatawan asing dan wisatawan domestik (nilai p = 0,942; = 0,05) serta tidak ada perbedaan sikap pencegahan pada wisatawan asing dan wisatawan domestik (nilai p = 0,422; = 0,05). Pengetahuan dan sikap pencegahan antara wisatawan asing dan wisatwan domestik adalah sama dimana tingkat pengetahuan mayoritas dalam kategori baik dan sikap pencegahannya mayoritas masih dalam kategori cukup. Hasil penelitian ini akan mempermudah pemberian informasi kesehatan pada wisatawan untuk mengurangi kasus rabies.
HUBUNGAN CITRA TUBUH DENGAN GANGGUAN PERILAKU MAKAN PADA REMAJA PUTRI PENGGUNA INSTAGRAM
Authors: Ariani Ni Kadek Novi , Swedarma Kadek Eka , Saputra I Kadek 
Published: April 2022

ABSTRAK
Penggunaan Instagram dalam bersosial media dapat memberikan dampak negatif secara tidak langsung pada remaja. Terobsesi pada selebgram yang memiliki bentuk tubuh yang ideal dapat menimbulkan ketidakpuasan remaja terhadap citra tubuh yang dimiliki. Hal ini dapat memicu gangguan perilaku makan pada remaja. Studi ini memiliki tujuan untuk mengidentifikasi hubungan citra tubuh dengan gangguan perilaku makan pada remaja putri pengguna Instagram di SMA (SLUA) Saraswati 1 Denpasar. Rancangan penelitian menggunakan deskriptif korelatif dengan pendekatan cross-sectional. Sampel berjumlah 150 remaja putri kelas X dan XI jurusan MIA dan IIS yang diambil dengan menggunakan teknik disproportionated stratified random sampling. Citra tubuh diukur menggunakan MBSRQ-AS 34 dan gangguan perilaku makan diukur menggunakan kuesioner EAT-26. Hasil penelitian ini menunjukan bahwa mayoritas responden memiliki citra tubuh sedang (51,3%) dan mayoritas berisiko mengalami gangguan perilaku makan (54,7%). Berdasarkan hasil uji spearman rank menunjukkan hasil p value 0,000 (p ? 0.05) dengan nilai koefisien korelasi sebesar 0,620. Instagram dapat menjadi platform yang menyebabkan ketidakpuasan akan citra tubuh yang dapat berujung pada gangguan perilaku makan sehingga remaja putri perlu mengevaluasi dan memiliki informasi yang baik terkait citra tubuh yang dimiliki agar tidak menyebabkan gangguan perilaku makan.
Analisis Dinamika Model Penyakit Toksoplasmosis pada Populasi Kucing dan Manusia
Authors: Rusdiani Riza , Kusnanto Ali , Sianturi Paian 
Published: April 2022

Abstract: Toxoplasmosis is a disease that is identical to cats. This disease is caused by the parasite Toxoplasma gondii. In this study, a mathematical model of the spread of toxoplasmosis was reviewed with various population size. In this study, model construction, fixed point analysis and parameter sensitivity analysis were carried out. From the sensitivity analysis, it is shown that the cat transmission rate from a susceptible cat population to an infected cat population (horizontal transmission rate) and the probability of a susceptible cat born from an infected cat (vertical transmission rate) are found as sensitive parameters on production number ( Decreasing the horizontal transmission rate and an increase value of the vertical transmission rate can reduce the value of A decrease in the value of , results in a disease-free state will be achieved more quickly so that the disease is under control.
The Correlation between the Level of Hemoglobin and Learning Concentration on the Tenth-Grade Science Class Female Students in Senior High School of 3 Denpasar
Authors: Sari Ni Made Sekar , Suarningsih Ni Kadek Ayu , Antari Gusti Ayu Ary 
Published: April 2022

Hemoglobin is an iron rich protein present in red blood cells. Female student is vulnerable of having abnormally low levels of hemoglobin (?12 g/dL) due to blood losses during monthly menstruation, which can have an impact on decreasing their concentration to learn. The purpose of this research was to determine the correlation of hemoglobin levels and learning concentration on the tenth-grade science class female students in senior high school of 3 Denpasar. It used quantitative type of research and cross-sectional study model approach. The sampling methods used simple random sampling which is totaled 122 respondents. The data collection of hemoglobin levels used digital method Easy Touch GCHb and learning concentration used questionnaire with a total of 27 statements. Based statistic test on Pearson Product Moment, it showed hemoglobin level with learning concentration on the tenth-grade science class female students in senior high school of 3 Denpasar, has a strong and positive correlation (r=0,737; p<0,05).

Keywords: Hemoglobin Level, Learning Concentration, Female Student
DETEKSI Escherichia coli DAN ANGKA LEMPENG TOTAL BAKTERI PADA LAWAR BABI DI KECAMATAN ABIANSEMAL, KABUPATEN BADUNG, PROVINSI BALI
Authors: Antini Ni Ketut Febri , Kawuri Retno , Wijana I Made Sara 
Published: April 2022

ABSTRAK
Lawar babi adalah makanan khas Bali yang banyak disukai oleh masyarakat lokal dan para wisatawan yang berkunjung ke Bali. Makanan yang baik dan sehat harus terhindar dari cemaran bakteri patogen dan harus memenuhi syarat ambang batas maksimum cemaran bakteri menurut Badan Pengawas Obat dan Makanan (BPOM). Tujuan penelitian ini yaitu untuk mengetahui keberadaan Escherichia coli dan Angka Lempeng Total (ALT) Bakteri pada lawar putih dan lawar merah babi di Kecamatan Abiansemal, Kabupaten Badung, Provinsi Bali. Sampel diambil dari 10 pedagang secara acak di wilayah Abiansemal. Penelitian dilakukan di Laboratorium Mikrobiologi Program Studi Biologi FMIPA Universitas Udayana. Metode yang digunakan yaitu Platting method. Hasil pengujian diperoleh 40% lawar merah memiliki cemaran E. coli melebihi syarat BPOM yaitu < 3 MPN/g, sedangkan pada lawar putih sebanyak 30%. Cemaran E. coli tertinggi terjadi di Sangeh yaitu pada lawar merah (6,3 ± 0,76) MPN/g, sedangkan pada lawar putih (4,0 ± 0,49) MPN/g yang kejadiannya bersifat fluktuatif. Cemaran bakteri E. coli pada darah tertinggi di daerah Sangeh sebesar (1,9 ± 0,50) MPN/g. Hasil ALT bakteri pada lawar merah menunjukkan 80% tidak memenuhi syarat BPOM yaitu < 1 x 106 CFU/g, sedangkan lawar putih yang tidak memenuhi syarat BPOM sebesar 40%. Nilai ALT tertinggi pada darah babi di Sibang Gede II (Banjar Badung) yaitu sebesar (18,97 ± 0,42) x 103 CFU/g. Penggunaan darah segar sebagai pewarna merah menyebabkan meningkatnya cemaran bakteri pada lawar merah.