bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spirometry at diagnosis and overall survival in non‐small cell lung cancer patients
Authors: Zhai Ting , Li Yi , Brown Robert , Lanuti Michael , Gainor Justin F. , Christiani David C. 
Published: May 2022

AbstractPulmonary function can predict all‐cause mortality, and chronic obstructive pulmonary disease (COPD) is associated with worse overall survival (OS) in non‐small cell lung cancer (NSCLC) patients. Though pre‐operative lung function is predictive of in‐hospital mortality following lung cancer surgery, its predictive utility for long‐term survival is unclear. The prognostic role of commonly used spirometry tests in survival of lung cancer also remains uncertain. This study evaluates the role of spirometry at lung cancer diagnosis in predicting OS of NSCLC patients. This was a retrospective study using data from the Boston Lung Cancer Study on newly diagnosed NSCLC patients with spirometry tests performed before cancer therapy (n = 2805). Spirometric test values, after being categorized using quartiles, were analyzed for association with OS using univariate and risk‐adjusted multiple regression models. Further, we analyzed OS by the status of COPD determined by spirometry, and, among those with COPD, by its stage defined by the Global Initiative for Chronic Obstructive Lung Disease criteria. Both univariate and multiple regression models demonstrated that lower quartiles of actual and percent predicted forced expiratory volume in 1 second and forced vital capacity at lung cancer diagnosis were significantly associated with worse OS. Spirometry‐determined COPD, and more advanced stage of COPD at lung cancer diagnosis were associated with worse lung cancer OS. The findings provide evidence that a good pulmonary function at diagnosis may help improve OS in NSCLC patients.
γ‐Aromatic Butenolides of Microbial Source – A Review of Their Structures, Biological Activities and Biosynthesis
Authors: Fan Hao , Wei Xia , Si‐Tu Mei‐Xia , Lei Yan‐Hu , Zhou Feng‐Guo , Zhang Cui‐Xian 
Published: May 2022

Abstractγ‐Aromatic butenolides (γ‐AB) are an important type of structures found in many bioactive microbial secondary metabolites (SMs). γ‐AB refer to a group of natural products (NPs) containing five‐membered (unsaturated) lactones with 3‐phenyl and 4‐benzyl substituents. Their wide‐range biological activities have inspired pharmaceutical chemists to explore its biosynthesis mechanisms and design strategies to construct the γ‐AB skeleton. Recently, there are a great deal of interesting research progress on the structures, biological activities and biosynthesis of γ‐AB. This review will focus on these aspects and summarize the important achievements of γ‐AB from 1975 to 2021.
Congenital cutaneous candidiasis in a premature neonate: A case report
Authors: Ruiz‐Cabrera Jose Ricardo , Meléndrez‐Vásquez Daniela , Moreno Diana Melissa , Prieto‐Jure Reinaldo 
Published: May 2022

AbstractCongenital cutaneous candidiasis (CCC) is a rare and usually benign disorder that develops within the first week of life. It predominantly presents with diffuse maculopapular and papulopustular erythematous desquamating patches. We report a preterm neonate with respiratory distress syndrome and skin diffuse maculopapular lesions at birth. Candida albicans was isolated from skin and gastrointestinal fluid culture; she underwent medical treatment with topical and systemic antifungal with clinical improvement and skin lesions resolution.
Osteochondroma of talus: A case report from Nepal
Authors: Shah Ajay , Adhikari Shirish , Shah Sangam , Bhandari Prawesh Singh , Uprety Suresh 
Published: May 2022

AbstractOsteochondroma, the most frequent benign bone tumor, develops in the metaphysis of long bones including the proximal humerus, tibia, and distal femur. The involvement of talus is found only in a few patients. Here, we present a case of osteochondroma of the talus in a 52‐year‐old woman who presented with ankle pain and edema.
Longitudinally extensive transverse myelitis (LETM) secondary to SARS‐CoV‐2 infection: A recent reality in spinal cord injury rehabilitation
Authors: Fonseca João P. , Coelho Alexandra , Lourenço Ana C. , Pires César , Margalho Paulo 
Published: May 2022

AbstractTransverse myelitis can be a complication of SARS‐CoV‐2 infection. We report the case of a transverse myelitis related to SARS‐CoV‐2 infection. Beyond the disease itself, neurological involvement affects functionality. In this situation, physical and rehabilitation medicine plays a crucial role in managing patient rehabilitation.
Redox Mediators in Microbial Electrochemical Systems
Authors: Gemünde André , Lai Bin , Pause Laura , Krömer Jens , Holtmann Dirk 
Published: May 2022

AbstractRedox mediators are commonly used in microbial electrochemical systems to enable or enhance the electron transfer between microorganisms and electrodes. In recent studies, new insights into the mechanism of mediated extracellular electron transfer were gained, but some questions remain unanswered. In this review, some of the most outstanding research questions regarding the use of redox mediators in microbial electrochemical systems were discussed. These included the recycling of artificial and natural redox mediators, limitations in electron transfer rates by mediator turnover, metabolic burden, membrane permeability, and the putative interaction sites between commonly used redox mediators and the proteins of the electron transport chain of diverse electroactive microorganisms. To simplify the planning of mediator‐based bioelectrochemical systems, these molecular interaction sites were defined by their redox potential and are assigned to redox mediators, known or hypothesized to be able to transfer electrons from or to the specific interaction site. Furthermore, we addressed the kinetics of mediator transfer through the membrane and the potential rate‐limiting step in mediator‐based processes.
Electrochemical Study of Ion Transfers Processes at the Interfaces between Water and Trifluorotoluene and Its Derivatives
Authors: Liu Junjie , Zheng Xinhe , Hua Yutong , Deng Jintao , He Peng , Yu Zhengyou , Zhang Xianhao , Shi Xiaohong , Shao Yuanhua 
Published: May 2022

AbstractAs one phase constituting of a liquid/liquid (L/L) interface, suitable organic solvents are of great significance for the study of electrochemistry at a L/L interface. In this work, the thermodynamic and kinetic parameters of simple ion transfer (IT) at the water/trifluorotoluene (W/TFT) interface were measured using micro‐ and nanopipettes voltammetry, respectively. In addition to the study of model ions, we have also explored some ions whose transfer potentials are close to the two ends of the potential window. Inspired by the work of the W/TFT interface, we also further developed two novel L/L interfaces and investigated various simple IT reactions based on the W/o‐ and p‐methylbenzotrifluoride (W/o‐ and p‐MBTF) interfaces. The transfer potential and Gibbs energy of ITs across the W/o‐and p‐MBTF interface were determined by the analysis of the electrochemical voltametric curves. Special attention should be paid to that we can observe the IT peak or steady‐state of tetraamyl ammonium (TAA+) at W/o‐ and p‐MBTF interfaces with no difficulty, which is rather challenging at other L/L interfaces. Compared to the classical W/1,2‐dichloroethane (DCE) and W/nitrobenzene (NB) interfaces, the W/TFT and its derivatives interfaces exhibit low toxicity, favourable stability, and wider potential windows, which can be better choices for replacing the traditional organic solvents in the electrochemical study at a L/L interface.
PROTOCOL: Guidance for stakeholder engagement in guideline development: A scoping review
Authors: Petkovic Jennifer , Riddle Alison , Lytvyn Lyubov , Khabsa Joanne , Akl Elie A. , Welch Vivian , Magwood Olivia , Atwere Pearl , Graham Ian D. , Grant Sean , John Denny , Katikireddi Srinivasa Vittal , Langlois Etienne , Mustafa Reem A. , Todhunter‐Brown Alex , Schünemann Holger , Smith Maureen , Stein Airton T. , Concannon Tom , Tugwell Peter 
Published: May 2022

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: to identify, describe, and summarize existing guidance and methods for multistakeholder engagement throughout the health guideline development process.
Ligand Stabilization Strategy Boosted Electrode Kinetics in Cyanide Metal Organic Framework for Electrocatalytic Oxygen Evolution Reaction
Authors: Zhao Hongyang , Dandan Yin M. s. , Ali Wajid , Nawab Ali Khan B. s. , Ping Li M. s. , Xuezhen Fan B. s. , Ding Shujiang 
Published: May 2022

AbstractCyanide bridged frameworks are excellent pre‐catalysts towards oxygen evolution reaction. Control the hydrolysis product is crucial for design of highly active catalyst. Herein, we introduced pyrazine molecules pillared Hofmann‐type metal organic framework electrocatalysts. The in‐situ formed amorphous hydroxide provided high electrocatalytic activity and the interplanar pyrazine molecule offered structural stability towards alkaline environment, which effectively boosted the OER catalytic activity by offering more accessible active sites. The enhanced structural stability was justified by Raman spectroscopy. The overpotential, Tafel slope, and turn over frequency of the as‐synthesized Hofmann‐type MOF reached 306 mV, 15.6 mV dec−1 and 0.12 s−1, which is significantly better than that of Prussian blue analogue. This work justified the effectiveness of the ligand stabilization strategy in boosting the activity in OER catalysts.
A voltage fluctuation compensation control strategy at DC side for integrated power quality control device
Authors: Pan Guobing , Gong Fei , Zhou Yinghao , Wu Hao , Jin Libing , Wang Jianfeng 
Published: May 2022

AbstractThe power quality control process in the integrated power quality control device, especially for three‐phase unbalance control, usually leads to the capacitor voltage fluctuations on DC side. In rectifier control strategy, the output of the voltage loop is the reference value of the inner current loop, and the DC‐side voltage is the reference value of the voltage loop. Therefore, the DC‐side voltage instability will overlay a fluctuating component on the reference value, which affects the accuracy of the inner current loop control, causing a considerable impact on the transient performance of the integrated power quality control system. Hence, the stability of the DC‐side voltage becomes the main factor of the current loop control strategy. Unfortunately, in practical applications, such fluctuations on DC side are inevitable. In this paper, the DC‐side capacitor voltage fluctuation mechanism is studied, and a comprehensive power quality control strategy based on feed‐forward compensation is proposed to mitigate the DC capacitor voltage fluctuation influence. The proposed compensation control strategy prevents the impact of DC‐side voltage fluctuations on the control system. The simulation conducted on the developed experimental platform verified the feasibility and capability of the feed‐forward control strategy of the integrated power quality control system.
Diabetes mellitus and multiple myeloma; common features of two distinct entities
Authors: Tentolouris Anastasios , Ntanasis‐Stathopoulos Ioannis , Eleftheriadou Ioanna , Malandrakis Panagiotis , Tzeravini Evangelia , Gavriatopoulou Maria 
Published: May 2022

AbstractDiabetes mellitus (DM) has attained the status of a global pandemic. Cardiovascular disease (CV) was the leading cause of morbidity in people with type 2 DM, however, a transition from CV to cancer as the leading contributor to DM related death has been observed lately. Multiple myeloma (MM) is the second most common haematological malignancy. Obesity is a common risk factor for both DM and MM. Although data are limited, studies have shown that DM might be associated with increased risk for the development of MM. The presence of DM might affect the course of patients with MM, since hyperglycemia may have an impact on both the efficacy and the adverse effects of antimyeloma therapy. In parallel, DM and MM share common clinical presentations, such as nephropathy, neuropathy, and CV. In terms of antidiabetic medications, metformin might present a synergistic effect with antimyeloma drugs and also prevent some of the adverse effects of these drugs; pioglitazone might have favourable effects when given as add on treatment in people with relapsed or refractory MM. No clinically important interactions have been observed between antidiabetic agents and the most commonly used antimyeloma drugs. Further data are needed to examine the effect of all classes of antidiabetic medication on MM and its complications. A baseline assessment of risk factors for glucose intolerance and close monitoring of glucose levels during therapy is strongly suggested for patients with MM.
Thirst in stable heart failure patients; time to reconsider fluid restriction and prescribed diuretics
Authors: van der Wal Martje H.L. , Jaarsma Tiny , Jenneboer Lieset C. , Linssen Gerard C.M. 
Published: May 2022

AbstractAimsOne of the bothersome symptoms that heart failure (HF) patients can experience is thirst. There are limited data on the association between thirst and fluid intake and clinical variables. Therefore, the aim of this study was to describe severe thirst in stable HF patients and assess factors related to severe thirst, including actual fluid intake and sodium intake.Methods and resultsThe study had a cross‐sectional design. Stable HF patients from two HF clinics in the Netherlands were included and assessed thirst by a visual analogue scale ranging from 0 to 100. They also completed questionnaires on thirst distress, self‐care behaviour, and HF symptoms. A 3 day food diary was completed to assess actual fluid intake and sodium intake. Finally, patients collected urine for 24 h. Patients were divided into severe and low thirst based on thirst score and thirst distress. T‐tests, Mann–Whitney tests, and χ2 tests were conducted to assess differences between both groups. Multivariable logistic regression analysis was performed to assess factors associated with severe thirst. A total of 100 patients were included (40% female, mean age 72 ± 12) of which 68 completed the food diary. The mean thirst score was 28 ± 25, and 25% experienced severe thirst. The majority of patients (94%) were prescribed a fluid restriction, 37% had a restriction between 1500 and 2000 mL, and 32% a restriction of 1500 mL. Severe thirst in the total group with 100 patients was associated with a higher dose of loop diuretics [odds ratio (OR) 3.25; 95% confidence interval (CI) 1.01–10.45; P = 0.048] and a higher urine output over 24 h (OR 1.002; 95% CI 1.00–1.003; P = 0.010). In the group of patients who completed the food diary (N = 68), severe thirst was associated with a higher sodium intake (OR 1.002; 95% CI 1.001–1.003; P = 0.003), a higher dose of loop diuretics (OR 22.69; 95% CI 2.78–185.04; P = 0.004), and more fatigue (OR 11.2; 95% CI 1.54–82.12; P = 0.017).ConclusionsA quarter of all stable HF patients experienced severe thirst. A higher dose of loop diuretics was associated with more thirst; therefore, it might be important to review the dose of loop diuretics critically and try to decrease it in order to relieve severe thirst. Because all patients were prescribed a fluid restriction, a reconsideration of this restriction is also suggested.
Atomically Precise Cun(n=3, 6 and 11) Nanocatalysts for Alkyne‐Haloalkane‐Amine (AHA) Coupling Reaction
Authors: Yuan Jiajia , Yun Yapei , Tao Zhinan , Zhu Yanan N. , Li Lin , Sheng Hongting , Zhu Manzhou 
Published: May 2022

AbstractUltrafine nanoclusters with precise structure as catalysts are of particular interest due to high sites density, high metal atomic efficiency and potentially favorable metal‐support interactions. In this work, we used a simple wet impregnation method to fix three Cun(n=3, 6, 11) nanoclusters (NCs) on activated carbon (AC). The structural characteristics of the three obtained Cun(n=3, 6, 11)/AC catalysts were analyzed by FT‐IR, XRD, TEM and XPS. Cun(n=3, 6, 11)/AC catalysts are used for exploring catalytic performance of alkyne‐haloalkane‐amine (AHA) coupling reaction. The results show that Cun(n=3, 6, 11)/AC catalysts exhibited better catalytic activity for AHA coupling reaction than Cu salt and other non‐noble metal catalysts, with TON up to 715.4. This work provides a new way to understand the relationship between structure and catalytic performance of ultra‐small copper NCs.
Base‐Mediated Generation of Ketenimines from Ynamides: Addition of Hydrazones to Give Acetimidohydrazides**
Authors: Mahe Capucine , D'Hollander Agathe C. A. , Cariou Kevin 
Published: May 2022

AbstractUnder basic conditions, N‐arylketenimines were generated in situ from N‐Boc ynamides and reacted with various hydrazones. Under heating, an addition of the deprotonated hydrazone onto the central carbon of the ketenimines takes place giving rise to various acetimidohydrazides.
A Clickable Bioorthogonal Sydnone‐Aglycone for the Facile Preparation of a Core 1 O‐Glycan‐Array
Authors: Chinoy Zoeisha S. , Moremen Kelley W. , Friscourt Frédéric 
Published: May 2022

AbstractProtein‐O‐glycosylation has been shown to be essential for many biological processes. However, determining the exact relationship between O‐glycan structures and their biological activity remains challenging. Here we report that, unlike azides, sydnones can be incorporated as an aglycon into core 1 O‐glycans early‐on in their synthesis since it is compatible with carbohydrate chemistry and enzymatic glycosylations, allowing us to generate a small library of sydnone‐containing core 1 O‐glycans by chemoenzymatic synthesis. The sydnone‐aglycon was then employed for the facile preparation of an O‐glycan array, via bioorthogonal strain‐promoted sydnone‐alkyne cycloaddition click reaction, and in turn was utilized for the high‐throughput screening of O‐glycan‐lectin interactions. This sydnone‐aglycon, particularly adapted for O‐glycomics, is a valuable chemical tool that complements the limited technologies available for investigating O‐glycan structure‐activity relationships.
Bromide Oxidation: A Safe Strategy for Electrophilic Brominations
Authors: Van Kerrebroeck Reinout , Horsten Tomas , Stevens Christian V. 
Published: May 2022

AbstractBromination of organic substances is still an important reaction in modern synthetic chemistry. In view of the increasing demand for sustainable synthetic chemistry, oxidative bromination can play an important role to avoid the use of hazardous molecular bromine (Br2). In this review, a complete overview of the chemical oxidants will be provided which have been used for the electrophilic as well as radical brominations, starting from less hazardous bromide Br(−I); e. g., HBr or a bromide salt, with a focus on the differences caused by the choice of oxidant.
Reconfigurable metasurface emitters
Authors: Pahlavan Pooyan , Neshat Mohammad 
Published: May 2022

AbstractIn this article, we propose a reconfigurable metasurface emitter (MSE) with beam shaping capability without using any phase shifter or a superstrate. MSEs consist of repeating radiative inclusions (unit cells) distributed on a surface. The type, shape, geometry, and the arrangement of the radiative inclusions provide great flexibility to design high efficiency reconfigurable radiative surfaces with almost any desired property. Here, we propose a new metasurface emitter with parasitic inclusions for enhanced bandwidth and increased beam rotation as a special case of beam shaping. The design procedure of such MSE is explained, and its performance as an emitting surface is investigated through full wave simulations and measurements. In addition, we propose a technique for beam steering by integration of tunable components such as varactors to each inclusion. Using tunable components can provide reconfigurability for the radiated beam of MSE.
Comparative analysis of multicriteria decision‐making approaches for evaluation hydrogen projects development from wind energy
Authors: Hosseini Dehshiri Seyyed Jalaladdin , Zanjirchi Seyed Mahmoud 
Published: May 2022

SummaryNowadays energy demand has increased due to industrial development and population growth. On the other hand, attention to environmental issues has made it necessary to use renewable energy. The utilization of wind energy is emphasized due to low construction costs and rapid installation. Wind energy, on the other hand, can be stored via creating hydrogen because its power fluctuates at different times and is not uniform. The production of hydrogen and energy is essential to meet the needs of industries in different countries. Therefore, in this study, a comprehensive approach is presented to locating hydrogen production from wind energy using multicriteria decision‐making (MCDM). To implement the proposed approach, a case study in Iran and Hormozgan province is used. Hormozgan province is in good condition in terms of wind potential and many industries in this province need energy and hydrogen. The most appropriate factors were judged to be average wind speed, each region's number of refineries, and each region's rate of industrial development, with weights of 0.192, 0.167, and 0.141, respectively, using the stepwise weight assessment ratio analysis (SWARA) approach. The cities in Hormozgan province were then prioritized using the weighted aggregated sum product assessment (WASPAS) technique. Then, the sensitivity analysis of the ranking results was performed and The COmplex PRoportional ASsessment (COPRAS), additive ratio assessment (ARAS), and weighted sum methods (WSM) methodologies were then used to validate the results. For the development of hydrogen projects, Bandar Abbas was determined as the most suitable place. A 900‐kW turbine at Bandar Abbas will generate 532 730 kWh of power and 8620 kg of hydrogen annually.
Risk factor analysis of dental implants in patients with irradiated head and neck cancer
Authors: Lee Joongyo , Lee Jason Joon Bock , Cha In‐Ho , Park Kyung Ran , Lee Chang Geol 
Published: May 2022

AbstractBackgroundWe investigated dental implant outcomes in patients who had previously received radiotherapy (RT) for head and neck malignancies.MethodsWe reviewed 90 dental implants in 27 patients who received RT for head and neck cancer and received dental implants afterwards. The cumulative implant survival rate (CISR) was calculated. In addition, the implant quality was assessed using “Health Scale for Dental Implants.”ResultsThe CISR at 3 years was 79.6%. The mean radiation dose at the implant site (Dmean) was identified as an independent prognostic factor for implant survival. No implant failed if Dmean was less than 38 Gy. Regarding implant quality, dental implants in grafted bone and Dmean were independent risk factors.ConclusionsDmean was identified as an independent prognostic factor for implant survival and quality. Dental implants can be safely considered when Dmean is lower than 38 Gy.