bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Authors: Wallace Andrew , Porten Sima P. , Lo Amy A. , Oreper Daniel , Lounsbury Nicolas , Havnar Charles , Pechuan-Jorge Ximo , Zill Oliver A. , Meng Maxwell V. 
Published: March 2022

AbstractRenal cell carcinoma (RCC) with venous tumor thrombus (VTT) arising from the primary tumor occurs in approximately 10% of cases and is thought to represent more advanced disease. The intravascular nature of VTT suggests that it may serve as a source for hematogenous metastases. RCC with VTT and distant metastasis provides unique opportunities to examine the origins and emergence timing of these distinct tumor lesions, and to identify molecular correlates with disease state. We performed multi-region exome and RNA-sequencing analysis of 16 patients with RCC with VTT, with eight patients also having sequenced metastasis, to identify genomic alterations, biological pathways, and evolutionary processes contributing to VTT and metastasis, and to ask whether metastasis arises directly from or independent of VTT. No specific genomic alterations were associated with VTT. Hallmark copy-number alterations (deletions of 14q, 8p, and 4q) were associated with metastasis and disease recurrence, and secondary driver alterations tended to accumulate in metastatic lineages. Mismatch repair mutational signatures co-occurred across most tumors, suggesting a role for intracellular DNA damage in RCC. Robust phylogenetic timing analysis indicated that metastasis typically emerged before VTT, rather than deriving from it, with the earliest metastases predicted to emerge years before diagnosis. As a result, VTT in metastatic cases frequently derived from a metastatic lineage. Relative to the primary tumor, VTT upregulated immediate-early genes and transcriptional targets of the TNFα/NF-κB pathway, whereas metastases upregulated MTOR and transcriptional targets downstream of mTORC1 activation.Implications:These results suggest that VTT and metastasis formation occur independently, VTT presence alone does not necessarily imply more advanced disease with inevitably poor prognosis.
The Sense of Presence between Volumetric-Video and Avatar-Based Augmented Reality and Physical-Zoom Teaching Activities
Authors: Guo Xuanru , Yoshinaga Takashi , Hilton Aaron , Harumoto Shuji , Hilton Ema , Ono Shizuka , Seno Takeharu 
Published: March 2022

Abstract
Various types of Augmented Reality (AR) have been successfully applied to many highly operable and spatial teaching courses in medicine, chemistry, and others. AR has already shown advantages over traditional face-to-face and online teaching, such as Zoom or Teams meetings. However, it is unclear when comparing teaching activity whether new AR technologies can offer similar advantages disciplines that are non-highly operational or non-spatial in nature, such as Introduction to Psychology. In order to present teaching activities in three dimensions and all directions and realize the presence of a teacher's face movement, we developed two new methods: Volumetric video Augmented Reality (VAR) and Avatar-based Augmented Reality (AAR). We compared the effects of teaching psychology using four methods: VAR, AAR, face-to-face, and Zoom. The participants’ data were collected via questionnaires with which we conducted variance analysis and Pearson correlation analysis. Our experiments showed that there were no significant differences in the effects of teaching under the four different teaching methods, but the AAR and VAR groups had significantly higher curriculum novelty and satisfaction, 3D sensation and presence, and teacher's attractiveness than face-to-face and Zoom groups. The research demonstrated that both VAR and AAR can improve the sense of presence and satisfaction in teaching psychology-related courses.
A New Fragment for Peshitta Cod. 8 (Pusey-Gwilliam) and the Syriac Tradition of Mark
Authors: Zellmann-Rohrer Michael 
Published: March 2022

Abstract
Publication of a Syriac parchment codex fragment kept in the papyrus collection of the National Library of Austria (P. Vind. Syr. 5), which belongs to a gospel manuscript once in the “Syrian” monastery of Wadi el-Natrun, the rest of which is now in London (British Library, Add. MS 17114). The potential contribution of the reconstituted codex, which was adduced as cod. 8 in the edition of Pusey and Gwilliam, to the criticism of the text of the Syriac version is reexamined.
Populism and Law in Hungary – Introduction to the Special Issue
Authors: Hoffmann Tamás , Gárdos-Orosz Fruzsina 
Published: March 2022

Abstract
Populism is a nebulous concept that has almost as many definitions as scholars engaging with the concept that has a paradoxical relationship with law. On the one hand, populist politicians generally oppose the liberal ideal of separating politics and law, i.e. accepting that legal rules should limit political power, claiming that it would impede the expression of the popular will, yet they use legal regulation as their most important instrument to implement their policies. The chameleonic nature of populism and its instrumentalist approach to law presents a special challenge for lawyers that try to assess its impact on the domestic legal system. Populist legislation, after all, is seemingly indistinguishable from legislation adopted under non-populist regimes as populist regimes always claim to strictly adhere to formal procedural requirements and often justify the dramatic overhaul of previous rules invoking foreign examples.
Hungary is a perfect litmus test for the examination of legal changes under populist leaders, because in 2010 the right-wing Fidesz-Kdnp party coalition won two-thirds majority in Parliament – a self-described “revolution in the voting booths” -, which gave it the power to completely overhaul the Hungarian legal system, even changing the constitution. In the past 10 years, virtually every significant branch of Hungarian law was recodified, adopting inter alia new criminal, civil, administrative and labor codes. The authors of this special issue attempted to analyze some of the most pertinent changes, in the field of constitutional law, adjudication, tax law, labor law, criminal regulation and asylum legislation.
Two Decades of Penal Populism – The Case of Hungary
Authors: Boda Zsolt , Tóth Mihály , Hollán Miklós , Bartha Attila 
Published: March 2022

Abstract
Hungary Post-2010 has been ruled by Viktor Orbán and his right-wing Fidesz party and is generally regarded as a typical case of populist governance. Reforming the Penal Code was one of the first major policy changes initiated by Fidesz shortly after winning the 2010 elections. It introduced the ‘three-strikes’ principle into Hungarian penal policy which is considered a prime example of penal populism. It could be inferred that in the past decade Hungarian penal policy has been dominated by penal populism and punitive measures. This paper argues that reality is more nuanced and presents the concepts of penal populism and populist policy making, with a special focus on the Hungarian context. The article provides an overview of the most important penal policy measures in the past two decades and examines whether and how increased strictness of legislative acts influenced the sentencing practice. The paper highlights the related results of an empirical survey on public opinions about criminal law and ends with a case study exploration of the intersections of lowering the age limit of criminal responsibility and penal populism.
‘Everyday Judicial Populism’ in Hungary
Authors: Bencze Mátyás 
Published: March 2022

Abstract
Scholarly works on judicial populism tend to concentrate on the landmark judgments of constitutional courts and apex courts. Nonetheless, the examination of the activities of ordinary courts is of great importance as they shape the lives of citizens and can strengthen or curb populist politics. In this paper I analyze a phenomenon emerging in the adjudication of Hungarian ordinary courts which can be labelled ‘everyday judicial populism’. Based on case studies and empirical scrutiny I argue that the political populism of the Hungarian government has both a direct and an indirect, but clearly detectable, impact on judicial practice. As regards the latter, the government can manipulate (through its media) public opinion in certain court cases, and judges take this opinion - as the ‘vox populi’ - into consideration in their decision-making. At the end of the paper I examine the institutional conditions that have facilitated the emergence of judicial populism.
Labor Law Reforms after the Populist Turn in Hungary
Authors: Hungler Sara 
Published: March 2022

Abstract
The characteristics of Hungarian populism and its effects on labor and social policy are rather different compared to those of western Member States of the EU. These differences are due to the different experiences related to inter- and intra-EU migration and to the difference in how the EU’s austerity measures were imposed during the economic crisis. The two distinctive elements are the workfare regime which replaces the welfare state, and anti-pluralism. In the workfare model, ‘hard-working people’ are pictured as an idealized mass of employees who are disciplined and striving for betterment every day; and whose jobs and wellbeing are jeopardized by illegal migrants and the idle poor. However, labor law does not strengthen the rights of ‘hard-working people’ or support them in asserting their rights against their employers. While the Roma have been described as the undeserving poor and mainstreamed in everyday politics and practice, guarantees and protective measures have been severely curtailed in social policy, amplifying the insecurity and material deprivation of those who lose their jobs. Regarding collective labor law, the lack of an autonomous social dialogue supports anti-pluralist trends, a characteristic of populist governance. The fundamental elements of democratic control, such as participation or trade union rights have been largely eliminated to cement the executive power of the coalition.
A Process-Conditioned and Spatially Consistent Method for Reducing Systematic Biases in Modeled Streamflow
Authors: Bennett Andrew , Stein Adi , Cheng Yifan , Nijssen Bart , McGuire Marketa 
Published: March 2022

Abstract
Water resources planning often uses streamflow predictions made by hydrologic models. These simulated predictions have systematic errors that limit their usefulness as input to water management models. To account for these errors, streamflow predictions are bias corrected through statistical methods that adjust model predictions based on comparisons to reference datasets (such as observed streamflow). Existing bias correction methods have several shortcomings when used to correct spatially distributed streamflow predictions. First, existing bias correction methods destroy the spatiotemporal consistency of the streamflow predictions when these methods are applied independently at multiple sites across a river network. Second, bias correction techniques are usually built on time-invariant mappings between reference and simulated streamflow without accounting for the processes that underpin the systematic errors. We describe improved bias correction techniques that account for the river network topology and allow for corrections that account for other processes. Further, we present a workflow that allows the user to select whether to apply these techniques separately or in conjunction. We evaluate four different bias correction methods implemented with our workflow in the Yakima River basin in the northwestern United States. We find that all four methods reduce systematic bias in the simulated streamflow. The spatially consistent bias correction methods produce spatially distributed streamflow as well as bias-corrected incremental streamflow, which is suitable for input to water management models. We demonstrate how the spatially consistent method avoids creating flows that are inconsistent between upstream and downstream locations, while performing similar to existing methods. We also find that conditioning on daily minimum temperature, which we use as a proxy for snowmelt processes, improves the timing of the corrected streamflow.

Significance Statement
To make streamflow predictions from hydrologic models more informative and useful for water resources management they are often postprocessed by a statistical procedure known as bias correction. In this work we develop and demonstrate bias correction techniques that are specifically tailored to streamflow prediction. These new techniques will make modeled streamflow predictions more useful in complex river systems undergoing climate change.
Static hand gesture recognition based on hierarchical decision and classification of finger features
Authors: Li Yunfeng , Zhang Pengyue 
Published: March 2022

Abstract Considering that the distinctions among static hand gestures are the difference between fingers sticking out, a method of grouping and classifying hand gestures step by step by using the information of the quantity, direction, position and shape of the outstretched fingers was proposed this paper. Firstly, the gesture region was segmented by using the skin color information of the hand, and the gesture direction was normalized by using the direction information of the gesture contour lines. Secondly, the finger was segmented one by one by using convex decomposition in the hand gesture image based on the convex characteristic of the gesture shape. Thirdly, the features of quantity, direction, position and shape of the segmented fingers were extracted. Lastly, a hierarchical decision classifier embedded with deep sparse autoencoders was constructed. The quantity of fingers was used to divide the gesture images into groups first, then the direction, position and shape features of the fingers were used to subdivide and recognize gestures within each group. The experimental results show that the proposed method is robust as lighting, direction and scale changes and significantly superior to the traditional method both in the recognition rate and the recognition stability.
The effect of contrast agents on the anticoagulant properties of oral factor Xa inhibitors
Authors: Cavlan Burcu , Ari Selma , Ari Hasan , Çamci Sencer , Melek Mehmet , Bozat Tahsin 
Published: March 2022

Background Contrast agents may affect the anticoagulant properties of novel oral anticoagulants. Purpose To evaluate the effect of iohexol as a contrast agent on the anticoagulant activity of oral factor Xa inhibitors. Material and Methods The study included 65 individuals who underwent contrast computed tomography(CT). Group 1 comprised 20 patients using rivaroxaban, Group 2, 20 patients using apixaban, and Group 3, 20 patients using edoxaban. Group 4 was the control group of five healthy volunteers. Iohexol (60 mL) was used as a contrast agent. Blood samples of 2 mL were withdrawn into two tubes at 4 h after the drug dose and 1 h after the contrast CT (CT was performed 3 h after the drug was taken) from all the patients, and for the control group, at any time before and 1 h after contrast CT. The anticoagulant properties of rivaroxaban, apixaban, and edoxaban were evaluated using anti-factor Xa levels. Results The anti-factor Xa level was increased after using the contrast agent in the rivaroxaban group (0.66 ± 0.32 U/mL vs. 0.67 ± 0.32 U/mL; P = 0.01) and the edoxaban group (0.74 ± 0.35 U/mL vs. 0.76 ± 0.36 U/mL; P = 0.006). No significant difference was observed in the apixaban group (0.66 ± 0.33 U/mL vs. 0.66 ± 0.32 U/mL; P = 0.21) and control group (0.02 ± 0.01 U/mL vs. 0.03 ± 0.01 U/mL; P = 0.33). Conclusion The anticoagulant properties of rivaroxaban and edoxaban tended to increase significantly, but there was no statistically significant difference in the anticoagulant properties of apixaban after the administration of contrast agent. To determine whether the small laboratory difference has a clinical effect, there is a need for larger clinical trials (NCT04611386).
Evaluation of Accuracy of Tanaka-Johnston Mixed Dentition Analysis in North Karnataka Population: A Cross-Sectional Study
Authors: Bangi Sayeeda Laeque , Kondody Rony T. , Sana Safiya , Fatima Asma , Hussain Arshad 
Published: March 2022

Objectives: Estimating the mesiodistal dimensions of unerupted canines and premolars in early mixed dentition is a critical tool in space management. According to previous studies, tooth size varies by ethnicity which could affect diagnosis and treatment planning. The aim of the study was to know whether the Tanaka-Johnston method is valid for the North Karnataka population. Materials and Methods: A total of 4,600 school children (2,300 boys and 2,300 girls) (age 11-16 years) with no craniofacial skeletal abnormalities, with no history of orthodontic and orthopedic treatment or maxillofacial surgeries, from 2013 June to 2019 June were taken for mixed dentition analysis by the Tanaka-Johnston method. Pearson correlation test was used to identify the correlation between various variables. Results: The findings revealed a sexual dimorphism in the widths of canine and premolar widths in the maxillary and mandibular teeth. A statistically significant difference was found between the width of the sum of incisor widths and the actual widths of canine and premolars for maxillary and mandibular arches, regardless of gender. Conclusion: The Tanaka-Johnston analysis was not precise enough to be used for the North Karnataka population in its original form, so new regression equations were developed.
Serum thymus and activation-regulated chemokine level is associated with the severity of chronic kidney disease-associated pruritus in patients undergoing peritoneal dialysis
Authors: Nakayama Takashin , Morimoto Kohkichi , Uchiyama Kiyotaka , Kusahana Ei , Washida Naoki , Azegami Tatsuhiko , Kanda Takeshi , Yoshida Tadashi , Itoh Hiroshi 
Published: March 2022

Background: Thymus and activation-regulated chemokine (TARC), which induces a Th2-dominated inflammation, is a well-known biomarker that reflects the severity of atopic dermatitis. The present study aimed to evaluate TARC as a Th2-associated marker with chronic kidney disease-associated pruritus (CKD-aP) in patients with peritoneal dialysis (PD). Methods: This single-centre cross-sectional study included patients who underwent PD in our hospital between August 2020 and July 2021. The severity and impaired quality of life (QOL) of CKD-aP were assessed using the visual analogue scale (VAS) and Japanese version of the 5-D itch scale (5D-J), respectively. Results: A total of 48 patients with PD were included in the present study. Age and dialysis vintage were (mean ± SD) 64.8 ± 12.0 year and (median (IQR)) 38.5 (11.5–91.5) month, respectively. VAS and 5D-J scores were 3.3 ± 2.0 and 10.5 (9.0–12.0), respectively. Serum TARC level was 481.5 (278.9–603.4) pg/mL (upper limits of normal 450 pg/mL) and significantly correlated with VAS ( r = 0.39, p = 0.006) and 5D-J score ( r = 0.37, p = 0.009). Multivariate linear analysis revealed that higher serum TARC level was significantly associated with VAS ( p < 0.001) and 5D-J score ( p < 0.001). Furthermore, the serum brain natriuretic peptide level tended to be associated with VAS ( p = 0.060) and 5D-J score ( p = 0.029). Conclusion: Serum TARC level is an independent predictor of the severity and impaired QOL of CKD-aP in patients with PD, and TARC might be involved in the pathogenesis of CKD-aP.
Metabolic Bone Disease of Prematurity: Discerning Calcium Versus Phosphorus Deficiency and Role of Calcitriol in Its Management
Authors: Lee Yee Lin , Hassan Hasyma Abu , Vasanwala Rashida Farhad 
Published: March 2022

Introduction: Metabolic bone disease of prematurity (MBDP) is prevalent among preterm infants despite major advances in neonatal care. Initial and ongoing assessment of complete bone metabolic markers help direct correct therapeutic mineral replacement. Case Presentation: A preterm infant of 30 weeks gestation and birth weight 1 kg sustained multiple spontaneous metaphyseal fractures at 5 months of age. The infant had multiple comorbidities including perforated necrotizing enterocolitis, chronic lung disease, short gut syndrome, and total parenteral nutrition-related cholestasis. Initial metabolic bone profile showed a rising trend of alkaline phosphatase (ALP) with normal calcium and declining phosphorus levels despite ongoing phosphorus supplements. Further workup showed elevated parathyroid hormone (PTH), low tubular reabsorption of phosphate (TRP), and low 25-hydroxyvitamin D (25(OH)D) levels, suggesting calcium/vitamin D deficiency with secondary hyperparathyroidism rather than inadequate phosphorus intake. Calcium and vitamin D supplementation were commenced and optimized, resulting in a decline in PTH, but ALP remained elevated. Treatment with calcitriol at dose range of 0.07 mcg/kg/day to 0.12 mcg/kg/day for 4.5 months duration led to a fall in ALP and PTH to near normal levels. Conclusion: Early nutrition with focus on calcium, phosphorus, and vitamin D is crucial to prevent MBDP. MBDP assessment should include serum PTH, TRP, and 25(OH)D levels to determine the specific mineral deficiency so that calcium, phosphorus, or vitamin D can be supplemented appropriately. Calcitriol is an effective treatment modality for calcipenic rickets where targeted mineral supplementation has been optimized.
Management of Myeloproliferative Neoplasms (MPNs)
Authors: Nurgat Zubeir , Lawrence Myer 
Published: March 2022

Purpose To provide up to date guidance, practice recommendations and highlight barriers to medication adherence in the long-term management of chronic myeloproliferative neoplasms (MPNs). Aim Current drug therapy for MPN is not curative and has not been shown to prolong survival. The main indication for treatment is the prevention of thrombosis and medication adherence remains a challenge in this group of patients. Identifying potentially modifiable barriers to medication adherence including primary nonadherence and non-persistent adherence enables timely interventions to be put in place and improve overall medication adherence. Methods A systematic review of peer-reviewed literature and expert opinions was performed using electronic databases (PubMed, EMBASE, MEDLINE, and Web of Science) that were searched for articles reporting MPN and medication adherence. Discussions A case vignette is discussed throughout the article and expert opinion with international peer reviewed guidelines that are authored to support clinical decision making at the point of care were utilised. The evidence base was combined with more practical/clinical (data based) insight from real world clinical practice. Adoption of a broad range of digital health care activities and services in the health care system (telehealth applications) by the advanced practice providers (Non-Medical Prescribers-NMPs) in MPN clinics included medication prescribing and management, oral drug compliance and adherence evaluations, interventions, chronic care management, counselling and patient education on treatments. Conclusion Current drug therapy for MPN is neither curative nor has it been shown to prolong survival, and medication adherence remains a challenge in this group of patients. The longevity of the patients’ disease course may contribute to the high risk of non-adherence in this patient cohort. Poor adherence to long-term therapies severely compromises the effectiveness of treatment. Adherence interventions should be tailored to the needs of the patient in order to achieve maximum impact. Interventions aimed at improving adherence provide the best experience and outcome for the patient and their families and can have a profound impact on the quality of life and mitigation of disease consequences.