bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Do Spitzer IRAC Fluxes Compare to HST CALSPEC?
Authors: Bohlin Ralph C. , Krick Jessica E. , Gordon Karl D. , Hubeny Ivan 
Published: June 2022

Abstract
An accurate tabulation of stellar brightness in physical units is essential for a multitude of scientific endeavors. The HST/CALSPEC database of flux standards contains many stars with spectral coverage in the 0.115–1 μm range, with some extensions to longer wavelengths of 1.7 or 2.5 μm. Modeled flux distributions to 32 μm for calibration of JWST complement the shorter-wavelength HST measurements. Understanding the differences between IRAC observations and CALSPEC models is important for science that uses IR fluxes from multiple instruments, including JWST. The absolute flux of Spitzer IRAC photometry at 3.6–8 μm agrees with CALSPEC synthetic photometry to 1% for the three prime HST standards: G191B2B, GD153, and GD71. For a set of 17–22 A-star standards, the average IRAC difference rises from agreement at 3.6 μm to 3.4% ± 0.1% brighter than CALSPEC at 8 μm. For a smaller set of G-type stars, the average of the IRAC photometry falls below CALSPEC by as much as 3.7% ± 0.3% for IRAC1, while one G-type star, P330E, is consistent with the A-star ensemble of IRAC/CALSPEC ratios.
The Criterion for Chaos in Three-planet Systems
Authors: Rath Jeremy , Hadden Sam , Lithwick Yoram 
Published: June 2022

Abstract
We establish the criterion for chaos in three-planet systems, for systems similar to those discovered by the Kepler spacecraft. Our main results are as follows: (i) The simplest criterion, which is based on overlapping mean motion resonances (MMRs), only agrees with numerical simulations at a very crude level. (ii) Much greater accuracy is attained by considering neighboring MMRs that do not overlap. We work out the widths of the chaotic zones around each of the neighbors, and also provide simple approximate expressions for the widths. (iii) Even greater accuracy is provided by the overlap of three-body resonances (3BRs), which accounts for the fine-grained structure seen in maps from N-body simulations, and also predicts Lyapunov times. From previous studies, it is unclear whether interplanetary chaos should be attributed to the overlap of MMRs or of 3BRs. We show that the two apparently contradictory viewpoints are in fact consistent: both predict the same criterion for chaos. (iv) We compare the predicted criterion with high-resolution maps of chaos from N-body simulations, and show that they agree at a high level of detail.
Measurement of the Relativistic Sunyaev–Zeldovich Correction in RX J1347.5-1145
Authors: Butler Victoria L. , Feder Richard M. , Daylan Tansu , Mantz Adam B. , Mercado Dale , Montaña Alfredo , Portillo Stephen K. N. , Sayers Jack , Vaughan Benjamin J. , Zemcov Michael , Zitrin Adi 
Published: June 2022

Abstract
We present a measurement of the relativistic corrections to the thermal Sunyaev–Zel’dovich (SZ) effect spectrum, the rSZ effect, toward the massive galaxy cluster RX J1347.5-1145 by combining submillimeter images from Herschel-SPIRE with millimeter wavelength Bolocam maps. Our analysis simultaneously models the SZ effect signal, the population of cosmic infrared background galaxies, and the galactic cirrus dust emission in a manner that fully accounts for their spatial and frequency-dependent correlations. Gravitational lensing of background galaxies by RX J1347.5-1145 is included in our methodology based on a mass model derived from the Hubble Space Telescope observations. Utilizing a set of realistic mock observations, we employ a forward modeling approach that accounts for the non-Gaussian covariances between the observed astrophysical components to determine the posterior distribution of SZ effect brightness values consistent with the observed data. We determine a maximum a posteriori (MAP) value of the average Comptonization parameter of the intracluster medium (ICM) within R
2500 to be 〈y〉2500 = 1.56 × 10−4, with corresponding 68% credible interval [1.42, 1.63] × 10−4, and a MAP ICM electron temperature of 〈T
sz〉2500 = 22.4 keV with 68% credible interval spanning [10.4, 33.0] keV. This is in good agreement with the pressure-weighted temperature obtained from Chandra X-ray observations, 〈T
x,pw〉2500 = 17.4 ± 2.3 keV. We aim to apply this methodology to comparable existing data for a sample of 39 galaxy clusters, with an estimated uncertainty on the ensemble mean 〈T
sz〉2500 at the ≃ 1 keV level, sufficiently precise to probe ICM physics and to inform X-ray temperature calibration.
The Influence of Surface Binding Energy on Sputtering in Models of the Sodium Exosphere of Mercury
Authors: Killen Rosemary M. , Morrissey Liam S. , Burger Matthew H. , Vervack Ronald J. , Tucker Orenthal J. , Savin Daniel W. 
Published: June 2022

Abstract
We have simulated the sodium (Na) exosphere of Mercury to show how the exosphere is affected by the assumed surface binding energy (SBE) of Na in the sputtered component. We constrained ion precipitation onto the surface using distributions for the cusp regions that are consistent with measurements by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging Fast Imaging Plasma Spectrometer instrument. We have simulated sputtering with SBEs of 0.27, 2.6, 4.4, and 7.9 eV, with the lowest value commonly used in exosphere models and the highest from recent molecular dynamics calculations for the Na-bearing feldspar end-member, albite. A gradual change in the exosphere is seen as the yield decreases and the ejecta energy increases with increasing SBE. We describe the corresponding exosphere source functions for ion sputtering (IS), as well as for the previously studied processes of micrometeoroid impact vaporization and photon-stimulated desorption (PSD), along with their release energy distributions and spatial distributions. We have summed the contributions of the various source processes to explain how and when the different sources can be distinguished by observations. The modeled exosphere scale heights range from 72 km for PSD to over 1000 km for IS using a SBE of 7.9 eV. We find that the processes responsible for generating Mercury's Na exosphere are separable by measuring line-of-sight column densities tangent to the planet at various altitudes and positions around the planet. Our initial results are consistent with the Na being sputtered from a high-SBE material such as feldspar, which has been predicted to be abundant on the Mercury's surface.
Clinical Heterogeneity of Patients With Antinuclear Matrix Protein 2 Antibody–Positive Myositis: A Retrospective Cohort Study in China
Authors: Li Shanshan , Sun Chao , Zhang Ling , Han Junfeng , Yang Hanbo , Gao Suhao , He Linrong , Zhang Peiyao , Lu Xin , Shu Xiaoming , Wang Guochun 
Published: June 2022

ObjectiveHeterogeneity exists among patients with myositis who have antinuclear matrix protein 2 (anti-NXP2) antibodies, although they usually present with severe muscle weakness. This study aimed to investigate the differences in phenotypes and prognoses among adult patients with myositis who have anti-NXP2 antibodies.MethodsAdult patients with myositis who have anti-NXP2 antibodies were enrolled from January 2010 to December 2019. Their clinical features and laboratory data were recorded retrospectively. We followed up on their survival status until June 30, 2020. A hierarchical cluster analysis, Kaplan-Meier curves, and classification and regression trees were used to analyze the data.ResultsA total of 70 adult patients with myositis who have anti-NXP2 antibodies were enrolled. All patients experienced muscle weakness. A total of 11 patients did not present with rashes during disease progression, and 43 patients developed dysphagia. In total, 21 patients had interstitial lung disease (ILD), whereas no patients had rapidly progressive ILD. Hierarchical cluster analysis identified 2 clusters. Patients in cluster 1 were younger at disease onset, had a higher incidence of subcutaneous calcification, and had a lower incidence of V sign and shawl sign. Patients in cluster 2 had a higher frequency of ILD, accompanied by lower levels of lymphocytes and higher levels of serum ferritin. Moreover, patients in cluster 2 had worse prognoses.ConclusionPatients with myositis who have anti-NXP2 antibodies may present with different phenotypes that are characterized by unique features and prognoses.
The Association of Index-to-Ring Finger Ratio With Trapeziometacarpal Joint Osteoarthritis in an Elderly Korean Population
Authors: Hwang Ji Sup , Lee Sanghoon , Shin Jung Wook , Kim Ki Woong , Gong Hyun Sik 
Published: June 2022

ObjectiveIndex-to-ring finger ratio (IRFR) has been reported to be associated with joint osteoarthritis (OA). We aimed to evaluate the association between IRFR and trapeziometacarpal joint (TMCJ) OA in an elderly Korean population.MethodsA population-based sample included 604 participants with a mean age of 74.8 years. IRFR was radiographically measured by the ratio of the length of the right second to fourth phalangeal bones (“phalangeal IRFR”) and metacarpal bones (“metacarpal IRFR”), and was visually classified as either type 1 (index finger longer than or equal to ring finger) or type 2 (index finger shorter than ring finger). Odds ratios (ORs) for the presence of OA (Kellgren-Lawrence [KL] grade > 1) and for severe OA (KL grade > 2) were analyzed using logistic regression.ResultsThe phalangeal IRFR averaged 91.3%, the metacarpal IRFR 116.7%, and 304 out of 604 participants (50.3%) had type 2 IRFR. We found TMCJ OA in 112 participants (18.5%), and severe TMCJ OA in 33 participants (5.5%). Presence of TMCJ OA was significantly associated with age (OR 1.04; 95% CI 1.01-1.06) and metacarpal IRFR (OR 0.94; 95% CI 0.88-0.99), and severe TMCJ OA with age (OR 1.08; 95% CI 1.03-1.12) and type 2 IRFR (OR 3.07; 95% CI 1.13-8.33).ConclusionRadiographic IRFR, specifically metacarpal IRFR, was associated with the presence of TMCJ OA, and visual IRFR with severe TMCJ OA in both elderly Korean men and women. The results of this study suggest that IRFR might serve as an easily measurable biomarker to identify patients vulnerable to TMCJ OA.
Impact, influence, importance : comment « mesurer » la contribution des femmes à l’histoire de la philosophie ?
Authors: Wilkin Rebecca 
Published: June 2022

Cet article identifie l’une des causes de l’exclusion des femmes de l’histoire de la philosophie : l’influence causale qui en est le principe narratif. L’influence est souvent décrite comme l’effet direct du texte philosophique, mais en fait c’est le lecteur qui consent à se laisser influencer. Chaque lecteur aborde le texte qu’il lit avec des préjugés, et ces préjugés peuvent contribuer à déterminer l’influence qu’il choisit de lui accorder. Je me sers des ouvrages de Gabrielle Suchon et de Louise Dupin afin de montrer combien le critère de l’influence renforce la dépossession systématique des femmes en tant que philosophes.
Philosophies : féminin pluriel , retour d’expérience
Authors: Rey Anne-Lise 
Published: June 2022

L’article se propose de discuter les moyens d’intégrer des corpus de femmes philosophes dans l’histoire de la philosophie du xvii e siècle tout en se demandant si cette intégration ne conduit pas à changer le canon philosophique. Il discute pour cela la pensée d’autrices du xvii e siècle (Marie de Gournay, Gabrielle Suchon, Anna Maria van Schurman, Élisabeth de Bohème, Anne Conway, Damaris Masham, Jacqueline Pascal, Margaret Cavendish, Christine de Suède, Sophie de Hanovre, Jeanne-Marie Guyon), présentées et commentées dans une anthologie, Philosophies : féminin pluriel, à paraître chez Classiques Garnier.
Les importations et les exportations dans les anciens P.T.O.M. britanniques entre 1995 et 2018
Authors: Verny Jérôme , Forriez Maxime 
Published: June 2022

Les données de l' Observatory of Economic Complexity (O.E.C.) recensent l’intégralité des importations et des exportations entre 1995 et 2018. Celles concernant les P.T.O.M. britanniques en ont été extraites. Ce texte analyse leurs flux avant le brexit , et tente d' ’en comprendre les répercussions. Tous ces territoires sont de type insulaire. De fait, les partenaires commerciaux associés aux flux ont une propension à changer d’une année à l’autre, ce qui rend l’analyse des partenariats entre les territoires très complexe, car l’outiltraditionnel du top 5 est insuffisant du fait de son instabilité dans le temps. Ainsi, cette contribution essaye de lever cette obstruction en utilisant la méthode statistique de concordance des rangs à deux échelles territoriales. Fort de cet outil, une lecture plus précise peut être réalisée par des indicateurs traditionnels, ce qui permettra d’entrevoir l’impact global du brexit sur l’ensemble des P.T.O.M. britanniques.
In vitro evaluation of antimicrobial and antioxidant activities of honeybee venom and propolis collected from various regions in Egypt
Authors: Elswaby Shimaa , Sadik Mahmoud , Azouz Alaa , Emam Nadia , Ali Mohamed 
Published: June 2022

Background and objective
Honeybee products are commonly used as food and medicine. Recently, pharmacological properties of bee venom and propolis have been reported. However, the geographic origin of bee venom and propolis influences their chemical composition and biological activities. The antimicrobial and antioxidant properties of bee venom and propolis collected from different regions in Egypt were evaluated.

Materials and methods
Bee venom and propolis were collected from the regions of Kafr-Elsheikh, Fayoum, and Giza in Egypt. The antimicrobial and antioxidant effects of bee venom and propolis extracts obtained with various solvents were evaluated using the well-diffusion method and the 1,1-diphenyl-2-picrilidrazil free radical scavenging assay, respectively.

Results and conclusion
The antimicrobial activities of bee venom extracts were greater than those of propolis extracts, and ethanol extracts were more efficient than chloroform and water extracts. Extracts obtained from the Kafr-Elsheikh region were the most active, whereas those from the Giza region were less effective. Gram-positive bacteria were more sensitive than gram-negative bacteria and fungi. Propolis extracts were more effective antioxidants than bee venom extracts. The activities of extracts from the Kafr-Elsheikh or the Fayoum regions were comparable and greater than those of the corresponding extracts from the Giza region. Ethanolic extraction provided the greatest antioxidant potential. The biological activity of Egyptian bee venom or propolis varies significantly depending on the extraction solvent and geographical area of collection. These results provide insights into the antimicrobial and antioxidant properties of Egyptian bee venom and propolis and constitute a basis for further phytochemical and pharmacological research.
Quality by design approach to the development of self-microemulsifying systems for oral delivery of teriflunomide
Authors: Patel Alpesh D. , Shah Sayali , Patel Mukesh S. , Vyas Govind 
Published: June 2022

Objective
The present study was aimed at the development of a self-microemulsifying drug delivery system (SMEDDS) for the low water-soluble drug using quality by design (QbD) to enhance the bioavailability of drugs.

Experimental work
The components of the SMEDDS were preliminarily screened using the pseudoternary phase diagram as a solubility study. The patient-centric, quality target product profile, and critical quality attributes were earmarked. Preformulation studies were performed along with an initial risk assessment that facilitated the selection of lipids (i.e. Sefsol 218), surfactants (i.e. Acrysol EL-135), and cosurfactants (i.e. PEG 400) as Critical Material Attributes for the formulation of SMEDDS. Extreme vertices mixture design, given its utility and the pertinence to the design issue in hand, was chosen for the study. The various responses selected for this design were drug release at 20 min (%), transmittance (%), emulsification time (s), and globule size (nm). Eleven distinct formulations were prepared and measured to check the model fit. The optimization and model validation were finished by directing experimental runs.

Results and discussion
Sefsol 218 (oil), Acrysol EL-135 (surfactant), and PEG 400 (cosurfactant) showed the highest solubility. The fourier transform infrared spectroscopy (FTIR) study suggested that there may be no significant difference in the characteristic’s peak at a wavenumber of the drug in the presence of excipients. The studies have shown that the application of extreme vertices mixture design and the development of formulation in QbD resulted in a powerful and viable technique for improving the bioavailability of the drug. This was confirmed by the characteristics’ studies of the optimized batch like in vitro drug release in 20 min (73.44%), drug content (99.3%), emulsification time (25 s), transmittance (99.5%), droplet size (16.64 nm), polydispersibility index 0.170, and zeta potential −9.74 mV. A great agreement was observed among the predicted and experimental values for the average globule size and percentage of the drug released in 20 min. Furthermore, the optimal SMEDDS formulation exhibited fundamentally higher, extreme-plasma concentration, and area under the curve values a twofold higher value (P<0.05) than the teriflunomide suspension.

Conclusion
In summary, the present studies report successful QbD-oriented development of a novel oral teriflunomide-loaded SMEDDS formulation to noticeably improve the bioavailability of low water-soluble drugs.
Thoracoscopic management of posterior mediastinal neurogenic tumours
Authors: Bishnoi Sukhram , Asaf Belal Bin , Puri Harsh Vardhan , Pulle Mohan Venkatesh , Parikh Manan Bharatkumar , Kumar Reena , Kumar Arvind 
Published: June 2022

Background:
This study describes the surgical technique of thoracoscopic resection of posterior mediastinal neurogenic tumours and reporting the surgical outcomes.

Methods:
This is a retrospective analysis of 21 patients operated over 7 years in a dedicated thoracic surgery centre. The demographic and post-operative parameters along with complications were recorded and analysed.

Results:
Twelve patients had right-sided tumours, while 9 had left-sided lesions, and 9 were on the left side. The most common diagnosis was schwannoma (n = 15, 71.42%), followed by neurofibroma (n = 4, 19.04%). The average surgery duration was 104 min (85–135 min), and the mean blood loss was 120 ml (25 ml–250 ml). The average lesion size was 4.8 cm (2 cm–7 cm). Conversion to open procedure was required in one patient. Two patients (14.2%) developed complications. One patient developed Horner's Syndrome and the other developed post-operative lung atelectasis. The median follow-up was 36 months (6–90 months). No recurrence was observed during the follow-up period.

Conclusions:
Thoracoscopic approach to posterior mediastinal neurogenic tumours is feasible and allows for low morbidity, short hospital stay and superior cosmesis.
Multidisciplinary, minimally invasive approach for oesophageal perforations with delayed presentation
Authors: Kumar Arvind , Singla Vikas , Pulle Mohan Venkatesh , Asaf Belal Bin , Puri Harsh Vardhan , Bishnoi Sukhram 
Published: June 2022

Background:
The present study aims to report the outcomes of a multidisciplinary, minimally invasive approach to treating patients with delayed presentation of oesophageal perforation.

Patients and Methods:
The present study is a retrospective analysis of prospectively maintained data at a tertiary care centre. All patients with oesophageal perforation presenting over 48 h after the onset of symptoms and without oesophageal obstruction were included in the study. Self-expanding Metallic Stent (SEMS) or endoscopic clip placement was performed in all the patients, followed by video-assisted thoracoscopic surgery (VATS) debridement and decortication of pleural cavity collection. 'Success’ was defined as, discharge without the need of oesophageal diversion and complete healing of leak site at 8 weeks with successful removal of the stent.

Results:
Between March 2012 and December 2019, 12 patients (10 males, median age of 55 years– range of 39–71 years) with oesophageal perforation and delayed presentation underwent treatment with this approach. Ten patients had spontaneous perforation (83.3%) and one patient each had upper gastrointestinal endoscopy-induced and post-traumatic perforation. The median duration of symptoms was 8 days (range 3–31 days). SEMS was placed in ten patients and, in two patients, an over-the-scope clip was used. VATS decortication was done in ten patients (83.3%) and the remaining two (16.7%) underwent VATS debridement. One patient required oesophageal diversion and another patient expired due to sepsis. The overall success with this approach was 83.3%.

Conclusion:
This multidisciplinary, minimally invasive approach is feasible in patients with thoracic oesophageal perforation and delayed presentation, with a high success rate.
The outcome of bioabsorbable staple line reinforcement versus standard stapler for distal pancreatectomy
Authors: Elkomos Beshoy Effat , Elkomos Philopateer Effat , Salem Amir Ali , Adly Philobater Bhgat 
Published: June 2022

Background and Aim:
In the era of minimally invasive procedures and as a way to decrease the incidence of post-operative pancreatic fistula (POPF), the use of staplers for distal pancreatectomy (DP) has increased dramatically. Our aim was to investigate whether reinforced staplers decrease the incidence of clinically relevant PF after DP compared with staplers without reinforcement.

Methods:
PubMed, Scopus, Web of Science and Cochrane Library were searched for eligible studies from inception to 1 November 2021, and a systematic review and a meta-analysis were done to detect the outcomes after using reinforced staplers versus standard stapler for DP.

Results:
Seven studies with a total of 681 patients were included. The overall incidence of POPF and the incidence of Grade A POPF after DP are similar for the two groups (overall POPF, risk ratio [RR] = 0.85, 95% confidence interval [CI] = 0.71–1.01, P = 0.06; I
2 = 38% and Grade A POPF, RR = 1.15, 95% CI = 0.78–1.69, P = 0.47; I
2 = 49%). However, the incidence of clinically significant POPF (Grades B and C) is significantly lower in DP with reinforced staplers than DP with bare staplers (Grades B and C, RR = 0.45, 95% CI = 0.29–0.71, P = 0.0005; I
2 = 17%). Nevertheless, the time of the operation, the blood loss during surgical procedure, the hospital stay after the surgery and the thickness of the pancreas are similar for both techniques.

Conclusion:
Although staple line reinforcement after DP failed to prevent biochemical PF, it significantly reduced the rate of clinically relevant POPF in comparison to standard stapling.