bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visible but Hidden: An Intersectional Examination of Identity Management Among Sexual Minority Employees
Authors: Dhanani Lindsay Y. , Totton Rebecca R. , Hall Taylor K. , Pham Carolyn T. 
Published: September 2022

As organizations have increasingly prioritized the inclusion of sexual minorities, there has been a proliferation of studies examining the ways by which organizations can foster environments that enable sexual minorities to express themselves authentically at work. Yet, extant research has predominantly ignored the role of other social identities in shaping the experiences of sexual minority employees, their decisions regarding the ways they express their sexual identities at work, and the consequences of those decisions. The current study correspondingly draws on theorizing on intersectionality to propose that workplace experiences related to race, a visible identity, may alter the decisions employees make about the expression of their invisible sexual identities. We additionally extend current conceptualizations of identity management to consider the ways employees may manage the presentation of their more visible racial identities at work. Results indicated that harassment experienced on the basis of sexual orientation and race combined to influence identity management strategies related to sexual and racial identities. Furthermore, concealing one's sexual orientation and suppressing one's racial identity uniquely contributed to decrements in employee well-being and interacted to predict employee outcomes. Yet, the nature of the interactions varied by employee race. Findings from this study support the need to adopt an intersectional approach to understanding invisible inequalities at work and inform future theoretical and practical efforts aimed at fostering workplace inclusion. Keywords: identity management; sexual orientation; race; employee well-being
Successful extracorporeal membrane oxygenation therapy in a child with coronavirus 2019 disease-associated ARDS and chemotherapy for Ewing’s sarcoma
Authors: Niño-Taravilla Carmen , Zuleta-Morales Yuri , Otaola-Arca Hugo , Montenegro Benigno , Sotomayor F Cristian , Greppi Q Claudia , Silva Garay Pamela , Ortiz-Fritz Paula 
Published: September 2022

Most children and adolescents with SARS-CoV-2 infection show no or mild symptoms, but those with medical histories can be susceptible to more severe forms of disease. There are few reported cases of extracorporeal membrane oxygenation (ECMO) in pediatric patients with coronavirus disease 2019 (COVID-19). We present a previously healthy 13-year-old male diagnosed with metastatic Ewing’s sarcoma at the same time as catastrophic acute respiratory distress syndrome due to COVID-19, who was successfully supported by venovenous-ECMO while he received the corresponding chemotherapy protocol. ECMO can be used as salvage therapy in oncology pediatric patients with respiratory failure secondary to COVID-19. In addition, successful chemotherapy can be administered while patients are supported on ECMO.
The association between N-methyl-d-aspartate receptor availability and glutamate levels: A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls
Authors: Beck Katherine , Arumuham Atheeshaan , Brugger Stefan , McCutcheon Robert A , Veronese Mattia , Santangelo Barbara , McGinnity Colm J , Dunn Joel , Kaar Stephen , Singh Nisha , Pillinger Toby , Borgan Faith , Sementa Teresa , Neji Radhouene , Jauhar Sameer , Aigbirhio Franklin , Boros Istvan , Turkheimer Federico , Hammers Alexander , Lythgoe David , Stone James , Howes Oliver D 
Published: September 2022

Background: Evidence from post-mortem studies and in vivo imaging studies suggests there may be reduced N-methyl-d-aspartate receptor (NMDAR) levels in the hippocampus in patients with schizophrenia. Other studies have reported increased glutamate in striatum in schizophrenia patients. It has been hypothesised that NMDAR hypofunction leads to the disinhibition of glutamatergic signalling; however, this has not been tested in vivo. Methods: In this study, we investigated the relationship between hippocampal NMDAR and striatal glutamate using simultaneous positron emission tomography-magnetic resonance (PET-MR) imaging. We recruited 40 volunteers to this cross-sectional study; 21 patients with schizophrenia, all in their first episode of illness, and 19 healthy controls. We measured hippocampal NMDAR availability using the PET ligand [18F]GE179. This was indexed relative to whole brain as the distribution volume ratio (DVR). Striatal glutamatergic indices (glutamate and Glx) were acquired simultaneously, using combined PET-MR proton magnetic resonance spectroscopy (1H-MRS). Results: A total of 33 individuals (15 healthy controls, 18 patients) were included in the analyses (mean (SD) age of controls, 27.31 (4.68) years; mean (SD) age of patients, 24.75 (4.33), 27 male and 6 female). We found an inverse relationship between hippocampal DVR and striatal glutamate levels in people with first-episode psychosis (rho = −0.74, p < 0.001) but not in healthy controls (rho = −0.22, p = 0.44). Conclusion: This study show that lower relative NMDAR availability in the hippocampus may drive increased striatal glutamate levels in patients with schizophrenia. Further work is required to determine whether these findings may yield new targets for drug development in schizophrenia.
Individual differences in cocaine-induced conditioned place preference in male rats: Behavioral and transcriptomic evidence
Authors: Atehortua Martinez Luisa Alessandra , Curis Emmanuel , Mekdad Nawel , Larrieu Claire , Courtin Cindie , Jourdren Laurent , Blugeon Corinne , Laplanche Jean-Louis , Megarbane Bruno , Marie-Claire Cynthia , Benturquia Nadia 
Published: September 2022

Background: Substance use disorder emerges in a small proportion of drug users and has the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate and characterize the variability in the expression of the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. Methods: A cocaine-CPP paradigm in male Sprague–Dawley rats with an extinction period of 12 days and reinstatement was conducted. A statistical model was developed to distinguish rats expressing or not a cocaine-induced place preference. Results: Two groups of rats were identified: rats that did express rewarding effects (CPP expression (CPPE), score >102 s) and rats that did not (no CPP expression (nCPPE), score between −85 and 59 s). These two groups did not show significant differences in a battery of behavioral tests. To identify differentially expressed genes in the CPPE and nCPPE groups, a whole-transcriptome ribonucleic acid-sequencing analysis was performed in the nucleus accumbens (NAc) 24 h after the CPP test. Four immediate early genes ( Fos, Egr2, Nr4a1, and Zbtb37) were differentially expressed in the NAc of CPPE rats after expression of CPP. Variability in cocaine-induced place preference persisted in the CPPE and nCPPE groups after the extinction and reinstatement phases. Transcriptomic differences observed after reinstatement were distinct from those observed immediately after expression of CPP. Conclusion: These new findings provide insights into the identification of mechanisms underlying interindividual variability in the response to cocaine’s rewarding effects.
Effect of Anchor Density on Functional Outcomes After Arthroscopic Hip Labral Repair
Authors: Ernat Justin J. , Comfort Spencer M. , Jildeh Toufic R. , Ruzbarsky Joseph J. , Philippon Marc J. 
Published: September 2022

Background: While labral repair has been widely adopted as the first line treatment for labral injury during hip arthroscopy, there is no widespread consensus on the procedural technique, including the number of anchors that should be used to avoid recurrent instability and revision surgery. Purpose: To determine if anchor density can predict patient-reported outcomes after arthroscopic labral repair in the hip. Study Design: Cohort study; Level of evidence, 3. Methods: Patients aged 18 to 50 years who underwent primary hip arthroscopic surgery with labral repair between January 2011 and December 2016 were identified from a prospectively collected database. Exclusion criteria consisted of previous ipsilateral surgery, osteoarthritis (Tönnis grade >1), and severe cartilage defects (Outerbridge grade III/IV) or concomitant labral reconstruction, capsular reconstruction, or microfracture. Minimum 2-year patient-reported outcomes (modified Harris Hip Score [mHHS], Hip Outcome Score [HOS]–Activities of Daily Living [ADL], HOS–Sport Specific Subscale [SSS], 12-Item Short Form Health Survey [SF-12]), rates of achieving the minimal clinically important difference (MCID) and patient acceptable symptom state (PASS) for each score, revision surgery rate, and rate of conversion to total hip arthroplasty (THA) were compared based on anchor density (number of anchors per millimeter of labral tear). Results: A total of 634 hips (575 patients) with a mean age of 30.4 ± 9.5 years (range, 18.0-49.9 years) met inclusion criteria. The mean labral tear size was 31 ± 11 mm (range, 2-70 mm) with a median number of anchors used for labral repair of 3 (range, 1-7) and mean anchor density of 0.11 ± 0.08 anchors (range, 0.03-1.33) per millimeter of labral tear. Hips with a minimum 2-year follow-up (451/634 [71.1%]) had significant improvements on the mHHS, HOS-ADL, HOS-SSS, and SF-12 Physical Component Summary ( P < .001 for all). There was no significant correlation detected between anchor density or number of anchors used and postoperative scores (correlation coefficient range, –0.05 to 0.17; P > .05 for all). The rate of revision surgery was 6.4% (28 patients), with 8 hips found to have labral tears and/or deficiency on revision. Additionally, 6 hips (1.3%) had to undergo THA at a mean of 3.6 ± 2.1 years (range, 2.0-5.5 years). Conclusion: Anchor density did not have a correlation with postoperative outcomes, achieving the MCID or PASS, revision hip arthroscopic surgery, complications, or conversion to THA.
Web-Based Electronic Health Record Program: A Twelve-Month Evaluation on Pharmacist’s Intervention in Medicare Part D Annual Comprehensive Medication Review
Authors: Chong Mok Thoong , Chong Desiree S. 
Published: September 2022

Objective:The objective of this study was to evaluate the impact of pharmacist’s intervention on annual comprehensive medication review (Annual CMR) for Medicare Part D beneficiaries. Background: To develop a new approach to assess Medicare Part D Annual CMR using a technological tool. Methods: One hundred sixty-three (163) eligible Medicare Part D beneficiaries were enrolled. By using an Electronic Health Record (EHR) Program, the pharmacist was able to assess laboratory, pharmacy, diagnosis, and patient information. A post-medication review summary was provided to the medical providers and patients which included a medication action plan. At the end of 3 months, 6 months and 12 months after the medication review, data were collected, assessed and compared. Results: The study showed that pharmacist’s interventions were recommended to seventy-four (74) enrollees which comprised of 45% of the total enrollees. It showed that at 3-month, 6-month, and 12-month intervals after the medication review, the recommended interventions acknowledged and implemented by the medical providers were 20%, 51% and 64% respectively, which showed a significant difference over a 12-month period ( P-value <.05). Different types of pharmacist’s interventions that were recommended may include to initiate, to adjust and to discontinue medication. The most common disease states that required interventions were psychiatric disorder, cardiovascular disease, pulmonary disease, gastrointestinal disease, diabetes, dyslipidemia and pain. Conclusion: The finding of this study revealed that such a web-based EHR system was a very meaningful and effective tool in assisting pharmacists to assess the proper and safe use of medication in elderly patients.
Validation of the Modified Fatigue Impact Scale in patients with systemic lupus erythematosus
Authors: Junker Christina I , Dreyer Lene , Duch Kirsten , Waarst Gregersen Jon , Kristensen Salome 
Published: September 2022

Introduction Patients with systemic lupus erythematosus (SLE) experience significant fatigue, a debilitating symptom associated with reduced quality of life. There has not yet been agreed on a simple and reliable method for assessing fatigue in SLE. Objectives To investigate the internal consistency, test–retest reliability and construct validity (convergent and discriminant validity) of the Modified Fatigue Impact Scale (MFIS) in patients with SLE. The secondary objective was to investigate the contribution of disease activity and organ damage to fatigue. Methods Fatigue was assessed using the MFIS in 61 patients with SLE. Internal consistency of MFIS was assessed with Cronbach’s alpha (α) and Principal Component Analysis. Test–retest reliability was evaluated using the intraclass correlation coefficient (ICC). Construct validity was studied using Spearman’s rank correlation (rs). Associations between MFIS and disease activity and organ damage were estimated with rs. Results Internal consistency of the MFIS was excellent with Cronbach’s α = 0.97 (95% confidence interval (CI): 0.96–0.98) for the complete scale. Test–retest reliability was good with ICC = 0.89 (95% CI: 0.78–0.95, p < 0.001). Construct validity was confirmed by Spearman’s correlation (VT-SF36: rs = −0.73, p < 0.001. MH-SF36: rs = 0.70, p < 0.001). No significant correlation was found between the MFIS and SLEDAI (rs = 0.03, p = 0.83). There was a moderate correlation between MFIS and SLICC Damage Index (rs = 0.43, p < 0.001). Conclusion The present study found the MFIS to be a reliable and valid instrument for assessing fatigue in SLE. Further investigations are needed to clarify if an association between measured fatigue and disease components exists.
Maintenance ECT treatment in New Zealand: Local and national data
Authors: Stegmann Ben , Gale Chris , Glue Paul 
Published: September 2022

Objectives To retrospectively analyse patients receiving maintenance Electroconvulsive therapy (ECT), patterns of ECT treatment administration and impact on hospitalisation before and during treatment, in a single New Zealand District Health Board catchment. We also asked other District Health Boards in New Zealand for annual data on their use of maintenance ECT. Methods Regional analysis: retrospective analysis of patient-level data over 9 years. National analysis: survey of maintenance ECT/year. Results Regionally, 14 patients received maintenance ECT over 9 years. Patients were 50% male, with mean age 59 years, and principal diagnoses included schizophrenia, bipolar disorder and major depressive disorder. The time between ECT treatments tended to be shorter for patients with schizophrenia compared with those with mood disorders. Duration of time in hospital during maintenance ECT, compared with pre-ECT, was reduced by 52% for all patients, with greater reductions for patients with mood disorders compared with those with schizophrenia. Nationally, 19.7% of all ECT treatments in New Zealand (range 4–57%) were for maintenance treatment. Discussion Regional and national use patterns of maintenance ECT in New Zealand resemble those reported internationally. The RANZCP section of neurostimulation is planning ECT standards which would assist with ensuring coherence and quality of High-dose contrast-enhanced computed tomography/modified electroconvulsive therapy practice in New Zealand.
“Primary Correction of the Cleft Nasal Septum: A Systematic Review”
Authors: Bins Griffin P. , Dourado Justin , Tang Jason , Kogan Samuel , Runyan Christopher M. 
Published: September 2022

Patients affected by cleft lip and palate have a characteristic nasal deformity; however, the treatment timeline varies amongst providers. There has been a shift from a more conservative approach to earlier intervention in order to allow for more normal development of the nose. Form, function, and future development all must be considered. For this reason, this investigation was undertaken to present the current literature available on the effects to all aspects of primary septoplasty in the cleft nasal deformity. An initial list of 222 papers was identified, and it was determined that 16 papers fit the inclusion criteria. Studies were included in which the initial age of operation for the majority of patients was between 3 and 12 months and in which patients underwent septal repositioning at the time of cleft lip repair. These papers were all reviewed by a single author initially, and the results recorded. All results were then verified by a second author for accuracy and completeness. Symmetry was found to be improved by primary septoplasty. Growth was not found to be impaired in any study; data was insufficient to indicate that growth was improved. Obstruction was improved as determined both by imaging, endoscopy, and patient survey. Finally, reoperation rates occurred at an acceptable rate not exceeding that of primary rhinoplasty without septoplasty. Primary septoplasty leads to better aesthetic symmetry and function of the cleft nose without impairing growth. This change is maintained into adulthood often without the need for revisionary surgery.
Persistent subretinal fluid following tractional retinal detachment repair: An exploring use of dexamethasone implant
Authors: Huang Xinyuan , Shao Yan , Li Xiaorong 
Published: September 2022

Introduction To report a successful application of dexamethasone implants in the treatment of a massive amount of persistent subretinal fluid (SRF) following a tractional retinal detachment (TRD) surgery. Case report A 44-year-old woman was found to have SRF 1 week after a diabetic TRD surgery. The central macular thickness (CMT) reached up to 1.47 mm and remained high after a month's observation. For better restoration, 2 dexamethasone implants (Ozurdex) were applied at postoperative week 5 and 32 respectively and got good outcomes. The SRF decrease showed a close correlation with Ozurdex treatments: The CMT declined quickly in the next 16 weeks both after 2 times of Ozurdex applications (the linear regression slopes of CMT changes: −12.54 and −22.94, respectively). In contrast, in the interval of 2 injections, the CMT had few changes (the slope: −4.667) even if applying an anti-VEGF agent. Eventually, SRF was completely resolved 48 weeks after the surgery. Discussion Dexamethasone implant can be an option for effective treatment of persistent SRF after TRD repair, especially in some refractory cases. However, the mechanism remains unclear, and the treatment regimen needs to be explored based on more clinical trials.
Polymeric compounds based on thermoplastic elastomer styrene-butadiene-styrene block copolymers and siliconic rubber powder
Authors: Stelescu Maria Daniela , Sonmez Maria , Georgescu Mihai , Alexandrescu Laurentia , Nituica Mihaela , Gurau Dana 
Published: September 2022

This paper presents the obtaining and characterization of polymeric composites based on thermoplastic elastomer type styrene-butadiene-styrene block copolymers and vulcanized rubber powder. The rubber powder used was obtained as waste in the technological processes in the rubber industry. It was analyzed by determining the acetonic extract, ash and FTIR analysis and it was observed that the base elastomer in the rubber waste is silicone rubber, and the amounts of inorganic fillers, plasticizers, antioxidants, lubricants etc. existing in the rubber powder are lower than 19%. The samples were obtained by mixing technique, on Brabender Plasti-Corder internal mixer type. The test specimens necessary to determine the characteristics were obtained on a laboratory electrical press at 170°C, applying a force of 300 kN, and moulding time 6 min. The characteristics of the obtained samples show that the addition of rubber powder improved the hardness and elasticity, and by the applying compatibility method, namely crosslinking and grafting in melt, in dynamic regime, there was a significant increase in hardness, elasticity, modulus 100%, tensile strength, and the material obtained is more compact. The new composites have physical and mechanical properties suitable for producing a wide range of rubber consumer goods.
Socioeconomic status is not associated with unfavorable outcomes in patients with acute limb ischemia
Authors: Natour Abdul Kader , Shepard Alexander , Nypaver Timothy , Weaver Mitchell , Peshkepija Andi , Kafri Omar , Kabbani Loay 
Published: September 2022

Objective Whether socioeconomic status (SES) is associated with health outcomes in patients with acute limb ischemia (ALI) is largely unknown. We aimed to determine whether SES is associated with worse presentations and outcomes for patients with ALI. Methods We performed a retrospective medical record review of patients who presented with ALI between April 2016 and October 2020 at a single tertiary care center. SES was quantified using individual variables (median household income, level of education, and employment) and a composite endpoint, the neighborhood deprivation index (NDI). The NDI is a standardized and reproducible index that uses census tract data (higher number indicates lower SES status). The NDI summarizes 8 domains of socioeconomic deprivation. ALI severity was categorized using the Rutherford classification. The association between SES and the severity of ALI at presentation and between SES and other health outcomes were analyzed using bivariate analysis of variance, independent t test, and multivariate logistic regression. Results During the study period, 278 patients were treated for ALI, of whom 211 had complete SES data available. The mean age was 64 years, 55% were men, and 57% were White. The Rutherford classification of disease severity was grade 1, 2a, 2b, and 3 for 6%, 54%, 32%, and 8% of patients, respectively. Patients with a low SES status per the NDI were more likely to have a history of peripheral arterial disease and chronic kidney disease at presentation. The ALI etiology (thrombotic vs embolic) was not associated with SES. No significant differences were seen between SES and the severity of ALI at presentation ( p = 0.96) or the treatment modality ( p = 0.80). No associations between SES and 30-day or 1-year mortality were observed (mean NDI, 0.15 vs 0.26, p = 0.58, and 0.20 vs 0.26, p = 0.71, respectively) or between SES and 30-day or 1-year limb loss (mean NDI, 0.06 vs 0.30, p = 0.18, and 0.1 vs 0.32, p = 0.17, respectively). Lower SES (higher NDI) was associated with increased 30-day readmission (mean NDI, 0.49 vs 0.15, p = 0.021). However, this association was not significant on multivariate analysis (odds ratio 1.4, 95% CI 0.9–2.1, p = 0.06). Conclusions SES was not associated with the severity of ALI at patient presentation. Although SES was associated with the presence of peripheral arterial disease and chronic kidney disease at presentation, SES was not a predictor of short-term or 1-year limb loss and mortality. Overall, ALI presentation and treatment outcomes were independent of SES.