bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gabi wheat a panel of European elite lines as central stock for wheat genetic research
Authors: Gogna Abhishek , Schulthess Albert W. , Röder Marion S. , Ganal Martin W. , Reif Jochen C. 
Published: September 2022

AbstractIn plant sciences, curation and availability of interoperable phenotypic and genomic data is still in its infancy and represents an obstacle to rapid scientific discoveries in this field. To that end, supplementing the efforts being made to generate open access wheat genome, pan wheat genome and other bioinformatic resources, we present the GABI-WHEAT panel of elite European cultivars comprising 358 winter and 14 summer wheat varieties released between 1975 to 2007. The panel has been genotyped with SNP arrays of increasing density to investigate several important agronomic, quality and disease resistance traits. The robustness of investigated traits and interoperability of genomic and phenotypic data was assessed in the current publication with the aim to transform this panel into a public data resource for future genetic research in wheat. Consecutively, the phenotypic data was formatted to comply with FAIR principles and linked to online databases to substantiate panel origin information and quality. Thus, we were able to make a valuable resource available for plant science in a sustainable way.
Volumetric analysis of spontaneous bone healing after jaw cyst enucleation
Authors: Ku Jeong-Kui , Han Michael , Yongvikul Atapol , Huh Jong-Ki , Kim Jae-Young 
Published: September 2022

AbstractThe purpose of this study is to evaluate the degree of spontaneous bone healing after cyst enucleation as well as its contributing factors. Pre- and post-operative computed tomography (CT) scans of consecutive patients who had undergone jaw cyst enucleation were retrospectively analyzed. The outcome variable was healing ratio, which was calculated using the volume of the cyst before surgery and the volume of the defect in the bone after surgery. Predictor variables including duration of observation, pre-operative cyst size, age, gender, and involved jaw were analyzed to determine their influence. Forty-four subjects (30 Male and 14 Female, average 40.7 ± 15.7 years) were included in this study. Healing ratio was significantly lower during the first year (33.5 ± 32.8%) compared to the second (74.5 ± 24.2%) and subsequent years (74.2 ± 17.8%). In 35 patients who had follow-ups of over 1 year, the healing ratio was not affected by the pre-operative cyst size and upper/lower jaw except gender (p = 0.037, female > male) and age (p = 0.021, younger than 30 years > 30 years and older). The residual defect was significant larger in cysts 3 cc or larger (1.64 ± 1.54 cc) compared to smaller cysts (0.43 ± 0.42 cc, p = 0.006). The residual defect volume of large cysts was similar to those of the pre-operative volume of small cysts (1.47 ± 0.72 cc). In conclusion, spontaneous bone healing ratio of post-enucleation defects was about 73.5% after 12 months. Large cysts (> 3 cc) had larger defect, comparable to the volume of small cysts, but with altered contour. Additional treatment such as a bone graft may be considered especially in large cysts.
Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer
Authors: Komatsu Shuhei , Konishi Tomoki , Matsubara Daiki , Soga Koji , Shimomura Katsumi , Ikeda Jun , Taniguchi Fumihiro , Iwase Hiroya , Kubota Takeshi , Shioaki Yasuhiro , Otsuji Eigo 
Published: September 2022

AbstractEnteral nutrition has been reported to be safe and effective in malnourished patients undergoing upper gastrointestinal surgery. In this study, we devised night home enteral nutrition (N-HEN) as a novel nutritional strategy and evaluated the efficacy in gastric cancer patients following total gastrectomy. Between January 2017 and March 2021, 24 patients were prospectively included in the protocol and supported by N-HEN for three postoperative months through a jejunostomy during the night (Elental:1200 kcal/day), and 22 patients without N-HEN were followed as a control group (CG). Body weight loss, nutritional indicators and tolerance to chemotherapy were evaluated. After 3 and 6 months, patients with N-HEN had significantly less body weight loss than CG (3 months P < 0.0001: N-HEN 4.0% vs. CG 15.2%, 6 months P < 0.0001: N-HEN 7.7% vs. CG 17.7%). Prealbumin was significantly higher in patients with N-HEN than CG after 3 and 6 months (3 months P < 0.0001, 6 months P = 0.0037). Albumin, total protein and hemoglobin, tended to be higher after 3 and 6 months in patients with N-HEN than CG, and total cholesterol after 6 months. Concerning the tolerance to adjuvant chemotherapy in Stage II–III patients, patients with N-HEN significantly had a higher completion rate (P = 0.0420: N-HEN 70% vs. CG 29%) and longer duration (P = 0.0313: N-HEN 458 days vs. CG 261 days) as planned. Continuous monitoring of blood glucose concentration in patients with N-HEN did not show nocturnal hypoglycemia or hyperglycemia. N-HEN could be a novel enforced and physiologically effective nutritional strategy to support potentially malnourished patients following total gastrectomy.
Revisiting implementation of multiple natural enemies in pest management
Authors: Alharbi Weam , Sandhu Simran K. , Areshi Mounirah , Alotaibi Abeer , Alfaidi Mohammed , Al-Qadhi Ghada , Morozov Andrew Yu 
Published: September 2022

AbstractA major goal of biological control is the reduction and/or eradication of pests using various natural enemies, in particular, via deliberate infection of the target species by parasites. To enhance the biological control, a promising strategy seems to implement a multi-enemy assemblage rather than a single control agent. Although a large body of theoretical studies exists on co-infections in epidemiology and ecology, there is still a big gap in modelling outcomes of multi-enemy biological control. Here we theoretically investigate how the efficiency of biological control of a pest depends on the number of natural enemies used. We implement a combination of eco-epidemiological modelling and the Adaptive Dynamics game theory framework. We found that a progressive addition of parasite species increases the evolutionarily stable virulence of each parasite, and thus enhances the mortality of the target pest. However, using multiple enemies may have only a marginal effect on the success of biological control, or can even be counter-productive when the number of enemies is excessive. We found the possibility of evolutionary suicide, where one or several parasite species go extinct over the course of evolution. Finally, we demonstrate an interesting scenario of coexistence of multiple parasites at the edge of extinction.
A low-profile broadband crossed-dipole antenna with fractal structure and inverted-L plates
Authors: Feng Guirong , Qi Tianyi , Li Mingming , Li Jiachen , Wang Xin-wei , Yang Hai-long 
Published: September 2022

AbstractA low-profile broadband circularly polarized (CP) crossed-dipole antenna is proposed. In this antenna, the dipole uses a fractal-based structure with multiple similar patches for obtaining broadband CP radiation and impedance matching. The incorporation of the crossed-dipole antenna with four triangular parasitic patches improves both the impedance and axial ratio (AR) bandwidths. Four parasitic coupled inverted-L metal plates are loaded on the ground plane to significantly enhance the AR bandwidth and reduce the antenna profile. The measured results are in agreement with the simulations, which demonstrates that the proposed antenna has a low profile of 0.18 λ0, a − 10 dB impedance bandwidth of 91% (2.78–7.42 GHz), a 3 dB AR bandwidth of 81.5% (2.99–7.1 GHz), and a good right hand circular polarization (RHCP) radiation pattern with an average gain of 7.9 dBi over the whole operating band.
Analytical techniques for mapping multi-hazard with geo-environmental modeling approaches and UAV images
Authors: Kariminejad Narges , Pourghasemi Hamid Reza , Hosseinalizadeh Mohsen 
Published: September 2022

AbstractThe quantitative spatial analysis is a strong tool for the study of natural hazards and their interactions. Over the last decades, a range of techniques have been exceedingly used in spatial analysis, especially applying GIS and R software. In the present paper, the multi-hazard susceptibility maps compared in 2020 and 2021 using an array of data mining techniques, GIS tools, and Unmanned aerial vehicles. The produced maps imply the most effective morphometric parameters on collapsed pipes, gully heads, and landslides using the linear regression model. The multi-hazard maps prepared using seven classifiers of Boosted regression tree (BRT), Flexible discriminant analysis (FDA), Multivariate adaptive regression spline (MARS), Mixture discriminant analysis (MDA), Random forest (RF), Generalized linear model (GLM), and Support vector machine (SVM). The results of each model revealed that the greatest percentage of the study region was low susceptible to collapsed pipes, landslides, and gully heads, respectively. The results of the multi-hazard models represented that 52.22% and 48.18% of the study region were not susceptible to any hazards in 2020 and 2021, while 6.19% (2020) and 7.39% (2021) of the region were at the risk of all compound events. The validation results indicate the area under the receiver operating characteristic curve of all applied models was more than 0.70 for the landform susceptibility maps in 2020 and 2021. It was found where multiple events co-exist, what their potential interrelated effects are or how they interact jointly. It is the direction to take in the future to determine the combined effect of multi-hazards so that policymakers can have a better attitude toward sustainable management of environmental landscapes and support socio-economic development.
Classical theory of universal quantum work distribution in chaotic and disordered non-interacting Fermi systems
Authors: Grabarits András , Kormos Márton , Lovas Izabella , Zaránd Gergely 
Published: September 2022

AbstractWe present a universal theory of quantum work statistics in generic disordered non-interacting Fermi systems, displaying a chaotic single-particle spectrum captured by random matrix theory. We consider quantum quenches both within a driven random matrix formalism and in an experimentally accessible microscopic model, describing a two-dimensional disordered quantum dot. By extending Anderson’s orthogonality determinant formula to compute quantum work distribution, we demonstrate that work statistics is non-Gaussian and is characterized by a few dimensionless parameters. At longer times, quantum interference effects become irrelevant and the quantum work distribution is well-described in terms of a purely classical ladder model with a symmetric exclusion process in energy space, while bosonization and mean field methods provide accurate analytical expressions for the work statistics. Our results demonstrate the universality of work distribution in generic chaotic Fermi systems, captured by the analytical predictions of a mean field theory, and can be verified by calorimetric measurements on nanoscale circuits.
Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in Staphylococcus aureus
Authors: Manna Adhar C. , Leo Stefano , Girel Sergey , González-Ruiz Víctor , Rudaz Serge , Francois Patrice , Cheung Ambrose L. 
Published: September 2022

AbstractStaphylococcus aureus adapts to different environments by sensing and responding to diverse environmental cues. The responses are coordinately regulated by regulatory proteins, and small regulatory RNAs at the transcriptional and translational levels. Here, we characterized teg58, a SarA repressed sRNA, using ChIP-Seq and RNA-Seq analysis of a sarA mutant. Phenotypic and genetic analyses indicated that inactivation of teg58 led to reduced biofilm formation in a process that is independent of SarA, agr, PIA, and PSMs. RNA-Seq analysis of teg58 mutant revealed up-regulation of arginine biosynthesis genes (i.e., argGH) as well as the ability of the mutant to grow in a chemical defined medium (CDM) lacking l-arginine. Exogenous l-arginine or endogenous induction of argGH led to decreased biofilm formation in parental strains. Further analysis in vitro and in vivo demonstrated that the specific interaction between teg58 and the argGH occurred at the post-transcriptional level to repress arginine synthesis. Biochemical and genetic analyses of various arginine catabolic pathway genes demonstrated that the catabolic pathway did not play a significant role in reduced biofilm formation in the teg58 mutant. Overall, results suggest that teg58 is a regulatory sRNA that plays an important role in modulating arginine biosynthesis and biofilm formation in S. aureus.
Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report
Authors: Saßmannshausen Marlene , Behning Charlotte , Isselmann Ben , Schmid Matthias , Finger Robert P. , Holz Frank G. , Schmitz-Valckenberg Steffen , Pfau Maximilian ,   MACUSTAR Consortium, Agostini H. , Altay L. , Atia R. , Bandello F. , Basile P. G. , Behning C. , Belmouhand M. , Berger M. , Binns A. , Boon C. J. F. , Böttger M. , Bouchet C. , Brazier J. E. , Butt T. , Carapezzi C. , Carlton J. , Carneiro A. , Charil A. , Coimbra R. , Cozzi M. , Crabb D. P. , Cunha-Vaz J. , Dahlke C. , de Sisternes L. , Dunbar H. , Finger R. P. , Fletcher E. , Floyd H. , Francisco C. , Gutfleisch M. , Hogg R. , Holz F. G. , Hoyng C. B. , Kilani A. , Krätzschmar J. , Kühlewein L. , Larsen M. , Leal S. , Lechanteur Y. T. E. , Luhmann U. F. O. , Lüning A. , Marques I. , Martinho C. , Montesano G. , Mulyukov Z. , Paques M. , Parodi B. , Parravano M. , Penas S. , Peters T. , Peto T. , Pfau M. , Poor S. , Priglinger S. , Rowen D. , Rubin G. S. , Sahel J. , Sánchez C. , Sander O. , Saßmannshausen M. , Schmid M. , Schmitz-Valckenberg S. , Schrinner-Fenske H. , Siedlecki J. , Silva R. , Skelly A. , Souied E. , Staurenghi G. , Stöhr L. , Taylor D. J. , Terheyden J. H. , Thiele S. , Tufail A. , Varano M. , Vieweg L. , Wintergerst L. , Wolf A. , Zakaria N. , Thiele Sarah 
Published: September 2022

AbstractQuantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial–drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of − 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of − 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (− 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR’s value as a novel biomarker for AMD and disease progression.
Photo-engineered optoelectronic properties of indium tin oxide via reactive laser annealing
Authors: Hillier James Arthur , Patsalas Panos , Karfaridis Dimitrios , Camelio Sophie , Cranton Wayne , Nabok Alexei V. , Mellor Christopher J. , Koutsogeorgis Demosthenes C. , Kalfagiannis Nikolaos 
Published: September 2022

AbstractTransparent conductive oxides are appealing materials for optoelectronic and plasmonic applications as, amongst other advantages, their properties can be modulated by engineering their defects. Optimisation of this adjustment is, however, a complex design problem. This work examined the modification of the carrier transport properties of sputtered tin-doped indium oxide (ITO) via laser annealing in reactive environments. We relate the optical modifications to the structural, compositional, and electronic properties to elucidate the precise mechanisms behind the reactive laser annealing (ReLA) process. For sufficiently high laser fluence, we reveal an ambient-dependent and purely compositional modulation of the carrier concentration of ITO thin films. Hereby, we demonstrate that ReLA utilises the precise energy delivery of photonic processing to enhance the carrier mobility and finely tune the carrier concentration without significantly affecting the crystal structure. Exploitation of this phenomena may enable one to selectively engineer the optoelectronic properties of ITO, promising an alternative to the exploration of new materials for optoelectronic and photonic applications.
Association between maternal smoke exposure and congenital heart defects from a case–control study in China
Authors: Deng Changfei , Pu Jie , Deng Ying , Xie Liang , Yu Li , Liu Lijun , Guo Xiujing , Sandin Sven , Liu Hanmin , Dai Li 
Published: September 2022

AbstractThere is a gap in knowledge how maternal exposure to environmental tobacco smoke (ETS) is associated with offspring congenital heart defects (CHDs). In this case–control study, we collected data on 749 fetuses with CHDs and 880 fetuses without any congenital anomalies to examine the association of maternal ETS with fetal CHDs and the potentially moderating effect by maternal hazardous and noxious substances (HNS), periconceptional folate intake and paternal smoking. Maternal exposure to ETS in first trimester was associated with increased risk of CHDs in a dose–response gradient, with the AORs (95% CI) were1.38 (1.00–1.92), 1.60 (1.07–2.41), and 4.94 (2.43–10.05) for ETS < 1 h/day, 1–2 h/day, and ≥ 2 h/day, respectively. With the doubly unexposed group as reference categories, AORs for maternal ETS exposure ≥ 2 h/day in the absence of folate intake, in the presence of HNS exposure or paternal smoking, were 7.21, 11.43, and 8.83, respectively. Significant additive interaction between ETS exposure and maternal folate intake on CHDs was detected. Maternal ETS exposure during first trimester may increase the risk of offspring CHDs in a dose–response shape, and such effect may be modified by maternal folate intake or other potential factors.
Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization
Authors: Moztarzadeh Sina , Radeva Mariya Y. , Sepic Sara , Schuster Katharina , Hamad Ibrahim , Waschke Jens , García-Ponce Alexander 
Published: September 2022

AbstractAdducin (Add) is an actin binding protein participating in the stabilization of actin/spectrin networks, epithelial junctional turnover and cardiovascular disorders such as hypertension. Recently, we demonstrated that Add is required for adherens junctions (AJ) integrity. Here we hypothesized that Add regulates tight junctions (TJ) as well and may play a role in cAMP-mediated barrier enhancement. We evaluated the role of Add in MyEnd cells isolated from WT and Add-Knock-Out (KO) mice. Our results indicate that the lack of Add drastically alters the junctional localization and protein levels of major AJ and TJ components, including VE-Cadherin and claudin-5. We also showed that cAMP signaling induced by treatment with forskolin and rolipram (F/R) enhances the barrier integrity of WT but not Add-KO cells. The latter showed no junctional reorganization upon cAMP increase. The absence of Add also led to higher protein levels of the small GTPases Rac1 and RhoA. In vehicle-treated cells the activation level of Rac1 did not differ significantly when WT and Add-KO cells were compared. However, the lack of Add led to increased activity of RhoA. Moreover, F/R treatment triggered Rac1 activation only in WT cells. The function of Rac1 and RhoA per se was unaffected by the total ablation of Add, since direct activation with CN04 was still possible in both cell lines and led to improved endothelial barrier function. In the current study, we demonstrate that Add is required for the maintenance of endothelial barrier by regulating both AJ and TJ. Our data show that Add may act upstream of Rac1 as it is necessary for its activation via cAMP.
Geometry-controlled phase transition in vibrated granular media
Authors: Zuñiga René , Varas Germán , Job Stéphane 
Published: September 2022

AbstractWe report experiments on the dynamics of vibrated particles constrained in a two-dimensional vertical container, motivated by the following question: how to get the most out of a given external vibration to maximize internal disorder (e.g. to blend particles) and agitation (e.g. to absorb vibrations)? Granular media are analogs to classical thermodynamic systems, where the injection of energy can be achieved by shaking them: fluidization arises by tuning either the amplitude or the frequency of the oscillations. Alternatively, we explore what happens when another feature, the container geometry, is modified while keeping constant the energy injection. Our method consists in modifying the container base into a V-shape to break the symmetries of the inner particulate arrangement. The lattice contains a compact hexagonal solid-like crystalline phase coexisting with a loose amorphous fluid-like phase, at any thermal agitation. We show that both the solid-to-fluid volume fraction and the granular temperature depend not only on the external vibration but also on the number of topological defects triggered by the asymmetry of the container. The former relies on the statistics of the energy fluctuations and the latter is consistent with a two-dimensional melting transition described by the KTHNY theory.
A hybrid binary dwarf mongoose optimization algorithm with simulated annealing for feature selection on high dimensional multi-class datasets
Authors: Akinola Olatunji A. , Ezugwu Absalom E. , Oyelade Olaide N. , Agushaka Jeffrey O. 
Published: September 2022

AbstractThe dwarf mongoose optimization (DMO) algorithm developed in 2022 was applied to solve continuous mechanical engineering design problems with a considerable balance of the exploration and exploitation phases as a metaheuristic approach. Still, the DMO is restricted in its exploitation phase, somewhat hindering the algorithm's optimal performance. In this paper, we proposed a new hybrid method called the BDMSAO, which combines the binary variants of the DMO (or BDMO) and simulated annealing (SA) algorithm. In the modelling and implementation of the hybrid BDMSAO algorithm, the BDMO is employed and used as the global search method and the simulated annealing (SA) as the local search component to enhance the limited exploitative mechanism of the BDMO. The new hybrid algorithm was evaluated using eighteen (18) UCI machine learning datasets of low and medium dimensions. The BDMSAO was also tested using three high-dimensional medical datasets to assess its robustness. The results showed the efficacy of the BDMSAO in solving challenging feature selection problems on varying datasets dimensions and its outperformance over ten other methods in the study. Specifically, the BDMSAO achieved an overall result of 61.11% in producing the highest classification accuracy possible and getting 100% accuracy on 9 of 18 datasets. It also yielded the maximum accuracy obtainable on the three high-dimensional datasets utilized while achieving competitive performance regarding the number of features selected.