bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting empowerment for people living with dementia in nursing homes: Development and feasibility evaluation of an empowerment program
Authors: van Corven Charlotte , Bielderman Annemiek , Wijnen Mandy , Leontjevas Ruslan , Lucassen Peter LBJ , Graff Maud JL , Gerritsen Debby L 
Published: September 2022

Objectives This article describes the development and feasibility evaluation of an empowerment program for people living with dementia in nursing homes. Methods Development and feasibility evaluation of the empowerment program was guided by the British Medical Research Council’s (MRC) framework. In the developmental phase, we used intervention mapping to develop the theory- and evidence-based intervention. During the feasibility phase, two care teams utilised the program from September to December 2020. We evaluated the feasibility in terms of demand, acceptability, implementation, practicality, integration and limited efficacy. Findings This study showed that, according to healthcare professionals, the program was feasible for promoting empowerment for people living with dementia in a nursing home. Healthcare professionals mentioned an increased awareness regarding the four themes of empowerment (sense of identity, usefulness, control and self-worth), and greater focus on the small things that matter to residents. Healthcare professionals experienced challenges in involving family caregivers. Conclusion An important step is to take into account the implementation prerequisites that follow from our findings, and to further investigate feasibility, as the use of the program and data collection was hindered by the COVID-19 pandemic. Subsequent research could investigate the effects of the empowerment program.
Face, Content, and Construct Validity Evaluation of Simulation Models in General Surgery Laparoscopic Training and Education: A Systematic Review.
Authors: Rueda Esteban Roberto J. , López-McCormick Juan S. , Rodríguez-Bermeo Alejandra S. , Andrade Mateo , Hernández Restrepo Juan D. , Targarona Soler Eduardo M. 
Published: September 2022

Background Laparoscopic technical surgical skills (LTS) are considered a fundamental competence for General Surgery residents. Several simulation tools (ST) have been explored to develop LTS. Although a plethora of systematic reviews evaluate the translation of LTS developed in simulation to real surgery, there is a lack of evidence that clarifies effectiveness of different validated ST in acquisition of LTS in surgical residents. The aim of this systematic review (SR) is to summarize published evidence on ST validation used for surgery education and training. Methods A protocol was published in PROSPERO. A SR was carried out following PRISMA guidelines. Complete published articles in English or Spanish that validate either content or construct, plus another form of validation of ST to acquire LTS in general surgery were included. Articles that used only one validation or did not validate an ST were excluded. Results 1052 publications were initially identified across all searched databases. Title review identified 204 studies eligible for full text screening. 10 studies were included for final review. Two studies assessed both face and content, 4 face and construct, and 4 face, content and construct validity. None of the studies presented comparable outcomes due to metrics variation and scores used for the validation strategies. Conclusions This study assessed validated laparoscopic simulation models, particularly in content and construct validity. Articles reported an increased use of simulation models in laparoscopic training with positive feedback from trainees, but few studies reported validation of training model. Validation strategies are not standardized, limiting comparability between them.
Thrombin injection under B-flow and ultrasound guidance: A safe and effective treatment of pseudoaneurysms
Authors: Li Lu , Deng Hongyan , Yuan Ya , Ye Xinhua 
Published: September 2022

Purpose To evaluate the method of thrombin injection under B-flow and ultrasound guidance (BUGTI) for the treatment of pseudoaneurysms. Materials and methods Twenty-one patients suffering from pseudoaneurysm (PSA) were retrospectively reviewed at the First Affiliated Hospital of Nanjing Medical University in Nanjing, China, from January 2018 to August 2019. The patients were treated using an ultrasound-guided injection of thrombin (500 IU/mL) combined with B-mode blood flow imaging (B-flow). The information on the PSA, including the size of the arterial rupture and sac, flow rate, thrombin dose, and treatment outcome, was recorded during the procedure. Follow-up evaluation was performed at 1, 3, and 6 months after the treatment. Pearson’s correlation analysis was performed among the characteristics of PSA and the dose of thrombin. Result The age of patients ranged from 34 to 80 years and averaged 62.8 years. The maximum cross-sectional area of PSA ranged from 208 to 1148 mm2. All patients were treated with thrombin injections. The dose of thrombin ranged from 300 to 1667 IU. No reperfusions were detected at follow-up 6 months, and the BUGTI treatment was successful in all 21 cases. Pearson’s correlation analysis demonstrated that the dose of thrombin was positively correlated with the width (r = 0.449, p < .05) and maximum cross-sectional area (r = 0.504, p < .05) of PSA. Conclusion Thrombin injection under B-flow and ultrasound guidance is a rapid and effective treatment for PSA. Additionally, the sac size could be used to estimate the dose of thrombin.
Normal C-reactive protein in active psoriatic arthritis: results from real-world clinical practice
Authors: Gialouri Chrysoula G. , Evangelatos Gerasimos , Pappa Maria , Karamanakos Anastasios , Iliopoulos Alexios , Tektonidou Maria G. , Sfikakis Petros P. , Fragoulis George E. 
Published: September 2022

Background: The value of normal C-reactive protein (CRP) in psoriatic arthritis (PsA) is debatable. Objectives: To test the hypothesis that CRP is frequently normal in contemporary real-world PsA patients, despite active disease. Design: In this cross-sectional study, patients were divided into two groups: CRP ⩽ 0.5 mg/dl (normal) and CRP > 0.5 mg/dl (increased). Having as dependent variable the CRP status, these groups were compared for disease-related features, including composite disease activity indices [clinical Disease Activity in PSoriatic Arthritis (cDAPSA) and minimal disease activity (MDA)] and patient-reported outcomes (PROs). Agreement between CRP status and cDAPSA/MDA scores was calculated (Cohen’s kappa). Methods: Data from consecutive PsA patients attending two outpatient rheumatology clinics (January 2019–June 2021) were analysed. Results: From 128 patients enrolled (51.6% females; mean ± standard deviation age: 53.4 ± 11.7 years; 23.4%, 48.4% and 64.1% treated with glucocorticoids, conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and biologic DMARDs, respectively), two-thirds (66.4%, n = 85) had normal CRP values. CRP status was not associated with any of the disease-related parameters and PROs, but only with ESR [odds ratio: 1.04 (95% confidence interval: 1.01–1.06), p = 0.005]. Among patients with normal CRP, 45.9% (39/85) were on non-MDA state, while 21.2% (18/85) had cDAPSA-moderate and 5.9% (5/85) had cDAPSA-high disease activities. Conversely, 54.2% (39/72) of patients on non-MDA state and 52.3% (23/44) of those with cDAPSA-moderate or cDAPSA-high disease activity had normal CRP values. Cohen’s kappa between normal CRP and MDA, cDAPSA-remission, and cDAPSA-remission/low disease activity was –0.26, –0.21 and –0.22, respectively, displaying total disagreement. Conclusion: Normal CRP in PsA should not be used as surrogate marker of remission or low/MDA, therefore needs to be interpreted with caution in clinical decision-making.
Endoscopic Plantar Fascia Release Combined With Calcaneal Spur Resection: A Case Series of 40 Patients
Authors: Nakajima Kenichiro 
Published: September 2022

Purpose To review the cases of patients treated using endoscopic plantar fascia release (PFR) with calcaneal spur resection (CSR) and examine why the combined procedures cause complications. Methods The medical records of patients treated with endoscopic PFR with CSR from November 2017 to December 2019 with a follow-up of >2 years were reviewed. Results A total of 40 feet in 40 patients (22 females, 18 males) were enrolled. The mean age and body mass index were 51.1 years and 24.7 kg/m2, respectively. The mean follow-up duration was 5.7 years. The visual analog scale for pain improved from 80.7 to 8.8 mm, and the Japanese Society for Surgery of the Foot score improved from 44.7 to 95.6 points (Wilcoxon signed rank test, P < .001 for both). Complications occurred in 8 patients (20%): 3 had flatfoot, 3 had an injury to the first branch of the lateral plantar nerve, 1 had scar pain, and 1 had a wound infection. Conclusion The 40 patients treated with endoscopic PFR with CSR for plantar fasciitis had good outcomes with a high complication rate; the invasiveness of creating the working space for the combined procedures was thought to be responsible. Levels of Evidence: Level IV: Case series
Enhanced clinical task-based fMRI metrics through locally low-rank denoising of complex-valued data
Authors: Meyer Nolan K , Kang Daehun , Black David F , Campeau Norbert G , Welker Kirk M , Gray Erin M , In Myung-Ho , Shu Yunhong , Huston III John , Bernstein Matt A , Trzasko Joshua D 
Published: September 2022

Objective This study investigates a locally low-rank (LLR) denoising algorithm applied to source images from a clinical task-based functional MRI (fMRI) exam before post-processing for improving statistical confidence of task-based activation maps. Methods Task-based motor and language fMRI was obtained in eleven healthy volunteers under an IRB approved protocol. LLR denoising was then applied to raw complex-valued image data before fMRI processing. Activation maps generated from conventional non-denoised (control) data were compared with maps derived from LLR-denoised image data. Four board-certified neuroradiologists completed consensus assessment of activation maps; region-specific and aggregate motor and language consensus thresholds were then compared with nonparametric statistical tests. Additional evaluation included retrospective truncation of exam data without and with LLR denoising; a ROI-based analysis tracked t-statistics and temporal SNR (tSNR) as scan durations decreased. A test-retest assessment was performed; retest data were matched with initial test data and compared for one subject. Results fMRI activation maps generated from LLR-denoised data predominantly exhibited statistically significant ( p = 4.88×10–4 to p = 0.042; one p = 0.062) increases in consensus t-statistic thresholds for motor and language activation maps. Following data truncation, LLR data showed task-specific increases in t-statistics and tSNR respectively exceeding 20 and 50% compared to control. LLR denoising enabled truncation of exam durations while preserving cluster volumes at fixed thresholds. Test-retest showed variable activation with LLR data thresholded higher in matching initial test data. Conclusion LLR denoising affords robust increases in t-statistics on fMRI activation maps compared to routine processing, and offers potential for reduced scan duration while preserving map quality.
Synthesis of a bifunctional EDTA–carboxymethyl chitosan derivative and its potential as an adsorbent for the removal of Cu2+ ions from aqueous solutions
Authors: Weerasinghe Kavindya , Liyanage Sudantha , Kumarasinghe Upul R , Cooray Asitha T 
Published: September 2022

Chitosan is a well-studied biomaterial which has been widely used for environmental applications as an efficient natural polymer for the adsorption and removal of metal ions. Owing to its unique properties, chitosan shows good metal-binding behavior toward several different metal ions such as Cu2+, Zn2+, Cd2+, Ni2+, Co2+, and Ca2+. Chemical modifications with the introduction of functional groups have been carried out extensively and thereby producing various chitosan derivatives to increase the selectivity and adsorption capacity toward metal ions. The present work focuses on two such monofunctional derivatives, namely, carboxymethyl chitosan (CMC) and ethylenediaminetetraacetic acid chitosan (EDTA-CS) which have been recognized as excellent adsorbents for metal removal. The main objective of this study was to synthesize a new bifunctional chitosan derivative, namely, ethylenediaminetetraacetic acid–carboxymethyl chitosan (EDTA-CMC) by attaching both carboxymethyl and EDTA functional groups on the polymer backbone and thereby enhancing its metal-binding properties. The bifunctional derivative synthesis was conducted by combining the procedures of synthesis of CMC and EDTA-CS. Newly synthesized EDTA-CMC derivative was characterized by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscope analysis, and thermogravimetric analysis. Adsorption properties of EDTA-CMC were investigated with Cu2+ ions which produced an adsorption capacity of 111.90 mg g−1 for 1000.0 mg/L and 12.20 mg g−1 for 10.00 mg/L Cu2+ solutions. The preliminary results revealed that EDTA-CMC is an effective adsorbent than CMC to remove Cu2+ in aqueous samples. The effects of pH, initial concentration, and mass of the adsorbent in the adsorption process were studied. Under the optimized parameters of an adsorbent dosage of 10.00 mg and pH 5.5, a comparable maximum adsorption capacity up to 112.44 mg g−1 was achieved with a 150.00 mg/L of Cu2+ solution. Furthermore, EDTA-CMC showed good adsorption performance even after five cycles of regeneration.
Trends in Level of Evidence of Systematic Reviews in Sports Medicine, 2010-2020 : A Systematic Review and Meta-analysis
Authors: Paras Tyler , Sabzevari Soheil , Solomon David , Smith Clair , McDonough Christine , Lin Albert 
Published: September 2022

Background: Popularization of systematic reviews has been met with controversy because of concerns that the primary literature for certain topics may not be suited for systematic review and meta-analysis. Purpose: To assess the rate of publication of systematic reviews based on their level of evidence (LOE) in influential orthopaedic sports medicine journals and commonly studied topics in sports medicine. Study Design: Systematic review. Methods: An electronic search was performed using the PubMed database of studies published from January 2010 to December 2020. The advanced search function was used to identify systematic reviews from the Journal of Shoulder and Elbow Surgery ( JSES), American Journal of Sports Medicine ( AJSM), Arthroscopy, British Journal of Sports Medicine ( BJSM), Journal of Bone and Joint Surgery–American Volume ( JBJS), and Sports Medicine ( SM Auckland), as well as reviews of the most common areas of sports medicine research, including rotator cuff repair (RCR), shoulder instability (SI), anterior cruciate ligament reconstruction (ACLR), and meniscal repair. The LOE was assigned to each included study according to the Oxford Centre for Evidence-Based Medicine. Studies were grouped as LOE 1-2, LOE 3-5, and nonclinical systematic reviews. A negative binomial regression was used to determine the changes in publication rate over time. Results: A total of 2162 systematic reviews were included in this study. From 2010 to 2020, the rate of publication of LOE 3-5 systematic reviews increased significantly among most of the surveyed journals ( AJSM, P < .0001; Arthroscopy, P = .01; BJSM, P < .0001; JSES, P < .0001; SM Auckland, P < .0001), with the exception of JBJS ( P = .57). The rate of publication of LOE 1-2 systematic reviews increased in AJSM ( P < .0001), Arthroscopy ( P = .02), BJSM ( P < .0001), and SM Auckland ( P < .0001); however, no significant changes were seen in JBJS ( P = .08) or JSES ( P = .15). The publication rate of LOE 3-5 systematic reviews increased for all sports medicine topics surveyed (meniscal repair, P < .0001; RCR, P < .0001; SI, P < .0001; ACLR, P < .0001). However, the publication rate of LOE 1-2 studies only increased for RCR ( P = .0003) and ACLR ( P < .0001). Conclusion: The rate of publication of LOE 3-5 systematic reviews exponentially increased in orthopaedic sports medicine journals over the past decade, outpacing the publication rate of LOE 1-2 systematic reviews.
Correlating Biomechanical Gait Analysis With Patient-Reported Outcomes After Hip Arthroscopy for Femoroacetabular Impingement Syndrome
Authors: Kannan Abhishek S. , Hartwell Matthew J. , Grace Trevor , Hammond Eric , Soriano Kylen K.J. , Souza Richard B. , Zhang Alan L. 
Published: September 2022

Background: Postoperative biomechanics after hip arthroscopy for femoroacetabular impingement syndrome (FAIS) are an outcome of interest, but correlation with patient-reported outcomes (PROs) remains unclear. Purpose/Hypothesis: The purpose of this study was to assess the correlation between changes in hip biomechanics in FAIS patients after hip arthroscopy and changes in PRO scores. We hypothesized that gait analysis would demonstrate significant correlations between pre- and postoperative changes in biomechanics and changes in PRO scores. Study Design: Descriptive laboratory study. Methods: FAIS patients without dysplasia or arthritis who underwent primary hip arthroscopy for labral repair and femoroplasty underwent preoperative and 1-year postoperative 3-dimensional motion tracking and biomechanical testing during normal gait. Joint kinematics calculated included flexion/extension (sagittal plane), abduction/adduction (frontal plane), and internal/external rotation (transverse plane). Peak hip angles and moments were compared between baseline and 1-year postoperative measures. At baseline, 1-year, and 2-year postoperatively, patients completed the following PRO surveys: 12-Item Short Form Health Survey (SF-12), modified Harris Hip Score (mHHS), and Hip disability and Osteoarthritis Outcome Score (HOOS). Joint kinematics that significantly improved 1 year after surgery were assessed for correlations with PRO scores. Results: A total of 10 patients (12 hips) were enrolled prospectively. PROs significantly improved at 1 and 2 years postoperatively compared with baseline values for HOOS, mHHS, and SF-12 Physical Component Score, with all patients achieving the minimal clinically important difference (MCID) on the HOOS Sport/Recreation and Quality of Life subscales. From preoperatively to 1-year postoperatively, significant improvements were seen in peak hip abduction angle (from −2.3° ± 1.8° to −4.6° ± 1.8°; P = .0058) and peak hip extension moment (from −1.03 ± 0.19 to −0.85 ± 0.20 N·m/kg; P = .014); however, there were no significant correlations between these changes and the pre- to postoperative changes on any PRO scores. Conclusion: Gait analysis of FAIS patients after hip arthroscopy demonstrated small, albeit significant, changes in postoperative hip kinetics and kinematics; however, these changes did not correlate with the large, clinically significant improvements in PROs at 1 year after surgery. Clinical Relevance: The results of this study suggest that the degree of improvement in short-term PROs after hip arthroscopy for FAIS may not be related to small changes in biomechanics postoperatively.
Soft Tissue Deformation Modeling in the Procedure of Needle Insertion: A Kriging-Based Method
Authors: Lei Yong , Li Murong , Gao Dedong 
Published: September 2022

AbstractThe simulation and planning system (SPS) requires accurate and real-time feedback regarding the deformation of soft tissues during the needle insertion procedure. Traditional mechanical-based models such as the finite element method (FEM) are widely used to compute the deformations of soft tissue. However, it is difficult for the FEM or other methods to find a balance between an acceptable image fidelity and real-time deformation feedback due to their complex material properties, geometries and interaction mechanisms. In this paper, a Kriging-based method is applied to model the soft tissue deformation to strike a balance between the accuracy and efficiency of deformation feedback. Four combinations of regression and correlation functions are compared regarding their ability to predict the maximum deformations of ten characteristic markers at a fixed insertion depth. The results suggest that a first order regression function with Gaussian correlation functions can best fit the results of the ground truth. The functional response of the Kriging-based method is utilized to model the dynamic deformations of markers at a series of needle insertion depths. The feasibility of the method is verified by investigating the adaptation to step variations. Compared with the ground truth of the finite element (FE) results, the maximum residual is less than 0.92 mm in the Y direction and 0.31 mm in the X direction. The results suggest that the Kriging metamodel provides real-time deformation feedback for a target and an obstacle to a SPS.
Pou3f1 mediates the effect of Nfatc3 on ulcerative colitis-associated colorectal cancer by regulating inflammation
Authors: Lin Yan , Wang Dongxu , Zhao Hong , Li Dongyue , Li Xinning , Lin Lianjie 
Published: September 2022

Abstract
Background
Ulcerative colitis-associated colorectal cancer (UC-CRC) is an important complication of ulcerative colitis. Pou3f1 (POU class 3 homeobox 1) is a critical regulator for developmental events and cellular biological processes. However, the role of Pou3f1 in the development of UC-CRC is unclear.

Methods
In vivo, a UC-CRC mouse model was induced by azoxymethane (AOM) and dextran sulfate sodium (DSS). Body weight, colon length, mucosal damage, tumor formation, and survival rate were assessed to determine the progression of UC-CRC. Western blot, quantitative real-time PCR, ELISA, immunohistochemistry, immunofluorescence and TUNEL were performed to examine the severity of inflammation and tumorigenesis. In vitro, LPS-treated mouse bone marrow-derived macrophages (BMDMs) and RAW264.7 cells were used to study the role of Pou3f1 in inflammation. ChIP and luciferase reporter assays were used to confirm the interaction between Nfatc3 and Pou3f1.

Results
Pou3f1 expression was increased in the colons of UC-CRC mice, and its inhibition attenuated mucosal injury, reduced colon tumorigenesis and increased survival ratio. Knockdown of Pou3f1 suppressed cell proliferation and increased cell death in colon tumors. Both the in vivo and in vitro results showed that Pou3f1 depletion reduced the production of proinflammation mediators. In addition, ChIP and luciferase reporter assays demonstrated that Nfatc3 directly bound with the Pou3f1 promoter to induce its expression. The effect of Nfatc3 on the inflammatory response in macrophages was suppressed by Pou3f1 knockdown.

Conclusion
Overall, it outlines that Pou3f1 mediates the role of Nfatc3 in regulating macrophage inflammation and carcinogenesis in UC-CRC development.