bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical signatures of human colon cancers
Authors: Lopez-Crapez Evelyne , Costa Luca , Tosato Guillaume , Ramos Jeanne , Mazard Thibault , Guiramand Janique , Thierry Alain , Colinge Jacques , Milhiet Pierre-Emmanuel , Bénistant Christine 
Published: July 2022

AbstractBesides the standard parameters used for colorectal cancer (CRC) management, new features are needed in clinical practice to improve progression-free and overall survival. In some cancers, the microenvironment mechanical properties can contribute to cancer progression and metastasis formation, or constitute a physical barrier for drug penetration or immune cell infiltration. These mechanical properties remain poorly known for colon tissues. Using a multidisciplinary approach including clinical data, physics and geostatistics, we characterized the stiffness of healthy and malignant colon specimens. For this purpose, we analyzed a prospective cohort of 18 patients with untreated colon adenocarcinoma using atomic force microscopy to generate micrometer-scale mechanical maps. We characterized the stiffness of normal epithelium samples taken far away or close to the tumor area and selected tumor tissue areas. These data showed that normal epithelium was softer than tumors. In tumors, stroma areas were stiffer than malignant epithelial cell areas. Among the clinical parameters, tumor left location, higher stage, and RAS mutations were associated with increased tissue stiffness. Thus, in patients with CRC, measuring tumor tissue rigidity may have a translational value and an impact on patient care.
Late fetal demise, a risk factor for post-traumatic stress disorder
Authors: Abiola Lucile , Legendre Guillaume , Spiers Andrew , Parot-Schinkel Elsa , Hamel Jean-François , Duverger Philippe , Bouet Pierre-Emmanuel , Descamps Philippe , Quelen Caroline , Gillard Philippe , Riquin Elise 
Published: July 2022

AbstractLate-term fetal demise including fetal death in utero, late miscarriage and late termination of pregnancy are relatively frequent occurrences. Post-traumatic stress disorder (PTSD) is a pathology that finds its roots in exposure to a life-threatening event or an event related to death. Exposure to fetal death during a late-term fetal demise is, therefore, a situation at risk of trauma. The objective of this study was to assess the prevalence of PTSD symptoms in the short term among patients faced with late fetal demise, and to identify potential risk factors. All women were assessed at 15 days, one month, and three months after late fetal demise using the Impact of Event Scale-Revised (IES-R) and the Peritraumatic Dissociative Experiences Questionnaire (PDEQ). At 15 days, 44.2% of patients presented a pathological score on the IES-R (≥ 33). At one month and three months, this figure was 34.1% and 9.1% respectively. Factor associated with PTSD symptoms were: peritraumatic dissociation (p = 0.014), seeing the fetus during hospitalization (p = 0.035), holding the fetus in one’s arms (p = 0.046), and the organization of a funeral service (p = 0.025). Patients experiencing late fetal demise are at significant risk of trauma. Care providers should remain vigilant to identify high-risk situations to offer appropriate care.Clinical trials registration number: NCT03433989.
The challenge of HLA donor specific antibodies in the management of pancreatic islet transplantation: an illustrative case-series
Authors: Maanaoui Mehdi , Chetboun Mikael , Top Isabelle , Elsermans Vincent , Kerr-Conte Julie , Le Mapihan Kristell , Defrance Frederique , Gmyr Valéry , Hubert Thomas , Labalette Myriam , Hazzan Marc , Vantyghem Marie-Christine , Pattou François 
Published: July 2022

AbstractIslet transplantation is a unique paradigm in organ transplantation, since multiple donors are required to achieve complete insulin-independence. Preformed or de novo Donor Specific Antibodies (DSA) may target one or several donor islets, which adds complexity to the analysis of their impact. Adult patients with type 1 diabetes transplanted with pancreatic islets between 2005 and 2018 were included in a single-center observational study. Thirty-two recipients with available sera tested by solid-phase assays for anti-HLA antibodies during their whole follow-up were analyzed. Twenty-five recipients were islet-transplantation-alone recipients, and 7 islet-after-kidney recipients. Seven recipients presented with DSA at any time during follow-up (two with preformed DSA only, one with preformed and de novo DSA, 4 with de novo DSA only). Only islet-transplantation-alone recipients presented with de novo DSA. Three clinical trajectories were identified according to: 1/the presence of preformed DSA, 2/early de novo DSA or 3/late de novo DSA. Only late de novo DSA were associated with unfavorable outcomes, depicted by a decrease of the β-score. Islet transplantation with preformed DSA, even with high MFI values, is associated with favorable outcomes in our experience. On the contrary, de novo DSA, and especially late de novo DSA, may be associated with allograft loss.
Sequence matching enhanced 3D place recognition using candidate rearrangement
Authors: Li Chi , Yan Fei , Zhuang Yan 
Published: July 2022

AbstractDeep‐learning‐based 3D place recognition has received more attention since the data‐driven fashion is widely used for the 3D point cloud applications. Most of the existing deep‐learning‐based 3D place recognition methods only utilise a single scene for place recognition. However, a single scene may have measurement noise or observable dynamic object differences, which may lead to a reduction in recognition accuracy. To improve the performance of 3D place recognition, a sequence matching based rearrangement method is proposed. Our sequence matching method is based on an assignment algorithm and guides the candidate rearrangement in searching for a similar place. The global descriptor extraction adapts the effective sparse tensor representation and a simple pooling layer to obtain the global descriptor. A new loss function combination is employed to train the network. The proposed approach is evaluated on the popular 3D place recognition benchmarks, which proves the effectiveness of the proposed approach.
Versatile kernel reactivation for deep convolutional neural networks
Authors: Lee Jeong Jun , Kim Hyun 
Published: July 2022

AbstractSeveral networks exhibiting excellent performance in the field of computer vision still suffer from the challenge of over‐parameterization. Over‐parameterized networks have several parameters that cannot be trained, owing to the poor backpropagation process caused by a small L1 norm, and these parameters suppress the potential for network performance improvement. This study proposes a kernel reactivation method to improve network performance by reusing invalid kernels that cannot be utilized for training because of the small L1 norm. The results indicate that the accuracy of Cifar‐10 in ResNet‐110 is improved by 0.94% compared to the baseline, and the top‐1 and top‐5 accuracies of Tiny‐ImageNet in ResNet‐50 are improved by 1.87% and 1.03% compared to the baseline, respectively.
Raman spectroscopy based detection of corrosive sulfur in transformer oil: Method and application
Authors: Wang Ziyi , Song Ruimin , Chen Weigen , Zhang Xinyuan , Wang Pinyi 
Published: July 2022

AbstractIn order to overcome the shortcomings of traditional methods for corrosive sulfur detection in transformer oil, Raman spectroscopy based detection is proposed in this paper. The widely concerned corrosive sulfur, Dibenzyl Disulfide (DBDS), was chosen as the characteristic molecule to be detected. A series of oil samples with different DBDS concentrations was prepared. And these samples were extracted by 1‐methyl‐2‐pyrrolidinone for DBDS enrichment to improve the sensitivity of detection. Then Raman spectra of samples were obtained, and a linear model was established by analysing the relationship between the characteristic peak and the DBDS concentration. The limit of detection reached 7.98 mg/kg. For determining the DBDS concentrations causing sulfur corrosion, the sulfur weight content on the copper conductor surface was measured by Scanning Electron Microscope‐Energy Dispersive Spectrometer after a corrosion test. The results show that the corrosion limitation highly depends on the type of transformer oil, and the Raman spectroscopy detection can meet the limit of detection requirement in practical condition. Finally, an on‐site oil sample and five Lab‐made samples were detected via our new method and the current Gas Chromatography‐Mass Spectrometry based method. It is found that there is no significant divergence between the measurement results. And good applicability was also demonstrated in on‐site sample test.
Astrometric mass measurement of compact companions in binary systems with Gaia
Authors: Wang Yilun , Liao Shilong , Giacobbo Nicola , Olejak Aleksandra , Gao Jian , Liu Jifeng 
Published: July 2022

Context. For binary systems with an unseen primary and a luminous secondary, the astrometric wobble of the secondary could be used to study the primary. With Gaia, it is possible to measure the mass of the black hole or neutron star with a luminous companion (hereafter BH/NS-LC).
Aims. Our aim is to provide a method for predicting Gaia’s ability in measuring the mass of BH/NS-LCs. We also tried to estimate the number of solvable BH/NS-LCs using Gaia.
Methods. We used a realistic Markov chain Monte Carlo simulation of mock Gaia observations to obtain a relation between the uncertainty of mass measurement of the primary in BH/NS-LCs with the observable variables of the secondary astrometric orbit. Furthermore, we used the MOBSE code to evolve a Galactic BH/NS-LC sample with a combined Milky Way model. Our relation is applied to this sample to estimate the number of solvable BH/NS-LCs.
Results. We derived a good relation between the mass uncertainty and the binary parameters. For the first time, we show the quantitive influence of the period P, inclination i, eccentricity e, and ecliptic latitude β to the mass measurement. Our results suggest that 48−7+7 BH-LCs and 102−10+11 NS-LCs are solvable during a 5 yr Gaia mission. We also give the distribution of the distance and apparent magnitude of the Gaia solvable BH/NS-LCs. This solvable sample would be increased by additional spectroscopic data or a prolonged Gaia mission.
Conclusions. The mass uncertainty relation could be used in future simulations of BH/NS-LCs observed by Gaia. The prediction of the solvable BH/NS-LCs is not only influenced by the process in generating the Galactic BH/NS-LC sample, but is also affected by our uncertainty relation. In particular, the relations of parameters such as [P, e, i,ß] are very useful to correct the selection effect in the statistic results of the future BH/NS-LC sample observed by Gaia.
Einfluss der Coronapandemie auf die Leberchirurgie und
Lebertransplantationen in Deutschland
Authors: Yurttas Can , Schleicher Christina , Fischer Imma , Meisner Christoph , Nadalin Silvio , Königsrainer Alfred , Löffler Markus W. , Quante Markus 
Published: July 2022

Zusammenfassung
Hintergrund Die Leberchirurgie ist durch ein hohes perioperatives Risiko
und einen großen Ressourcenaufwand geprägt, aber die Operationsindikation ist
oftmals alternativlos. Die SARS-CoV-2-Pandemie führte weltweit zu
Einschränkungen in der chirurgischen Patientenversorgung und stellte daher auch
die Leberchirurgie vor neue Herausforderungen. Welchen Einfluss die Pandemie
allerdings auf die Leberchirurgie in Deutschland insgesamt hatte, ist bislang
nur unzureichend bekannt.
Methoden Auf Basis der durch das Statistische Bundesamt (Destatis)
erfassten Daten zu Prozedurenschlüsseln (OPS-Codes) vollstationärer Patienten in
Deutschland aus den Jahren 2010–2020 sowie Daten zu Organtransplantationen der
Deutschen Stiftung Organtransplantation (DSO) wurde retrospektiv die Anzahl
leberchirurgischer Prozeduren in Deutschland zu Beginn der Pandemie mit den
Vorjahresdaten sowie mit Zahlen aus dem Eurotransplant-Raum verglichen.
Ergebnisse Entsprechend der durch das Statistische Bundesamt
dokumentierten Prozedurenschlüssel unterlagen Operationen an der Leber sowie
Lebertransplantationen in Deutschland in den Jahren 2010 bis 2020 einer
jährlichen Schwankung, die auch im Pandemiejahr 2020, im Gegensatz zu anderen
europäischen Ländern, unverändert geblieben ist. Die Entwicklung der
postmortalen Lebertransplantation sowie der Leberlebendspenden ist in
Deutschland, gemäß den Zahlen der DSO, auch im Jahr 2020 stabil geblieben.
Schlussfolgerungen Die Anzahl leberchirurgischer Eingriffe in Deutschland
unterlag bis 2020 einer dynamischen Entwicklung, die auch im 1. Pandemiejahr
2020 keine deutliche Veränderung gezeigt hat. Die häufigsten an der Leber
durchgeführten Operationen sowie die Lebertransplantation entwickelten sich auch
zu Beginn der Pandemie quantitativ weitgehend stabil. Die Veröffentlichung von
Daten zu den entsprechenden Prozedurenschlüsseln für das Jahr 2021 bleibt
abzuwarten, um die weitere Entwicklung der Leberchirurgie und -transplantation
in Deutschland während der SARS-CoV-2-Pandemie beurteilen zu können.
Mechanochemical Asymmetric Transfer Hydrogenation of Diketones to Access Chiral 1,3-Diols under Solvent-Free Conditions
Authors: Wang Chengyi , Deng Shaomin , Cheng Tanyu , Liu Rui , Chen Rui , Liu Guohua 
Published: July 2022

AbstractA mechanochemical asymmetric transfer hydrogenation (ATH) of diketones in the presence of a ruthenium complex under solvent-free conditions was developed to provide chiral 1,3-diol derivatives. This protocol benefits from rapid reaction kinetics, no use of solvents, and excellent enantioselectivity. In addition, the mechanochemical ATH reaction can easily be performed on a gram scale.
Safety and efficacy of liquid nitrogen spray cryotherapy in Barrett’s neoplasia – a comprehensive review and meta-analysis
Authors: Chandan Saurabh , Bapaye Jay , Khan Shahab R. , Deliwala Smit , Mohan Babu P. , Ramai Daryl , Dhindsa Banreet S. , Goyal Hemant , Kassab Lena L. , Aziz Muhammad , Kamal Faisal , Facciorusso Antonio , Adler Douglas G. 
Published: July 2022

Abstract
Background and study aims Barrett’s esophagus (BE) is a precursor condition to esophageal adenocarcinoma (EAC), resulting in transformation of the squamous epithelium of distal esophagus to columnar-lined epithelium with intestinal metaplasia (IM). Liquid nitrogen spray cryotherapy (LNSC) is a non-contact method of BE eradication and has been used both as primary and salvage therapy. We conducted a systematic review and meta-analysis to assess the safety and efficacy of LNSC.
Methods We searched multiple databases from inception through December 2021 to identify studies on use of LNSC for Barrett’s neoplasia. Pooled estimates were calculated using random-effects model and results were expressed in terms of pooled proportions with relevant 95 % confidence intervals (CIs) of complete eradication (CE) of dysplasia(D), high grade dysplasia (HGD) and IM.
Results Fourteen studies with 707 patients were included in our final analysis. Overall pooled rates of CE-D, CE-HGD and CE-IM were 80.8 % (CI 77.4–83.8; I2 62), 90.3 % (CI 85.2–93.7; I2 33) and 55.8 % (CI 51.7–59.8; I2 73) with follow up ranging from 4.25 months to 69.7 months. In patients with follow up beyond 24 months, the rates of CE-D and CE-IM were 83.6 % (CI 77.6–88.2; I2 60) and 54.7 % (CI 47.6–61.6; I2 81). Among LNSC naïve patients with prior history of endoscopic resection, the rates were 79.9 % (CI 73.3–85.2; I2 50) and 67.1 % (CI 59.5–73.8; I2 0). Pooled rate of therapeutic failures, defined as lack of response to LNSC therapy, was 23.6 % (CI 19.4–28.3; I2 73). Post LNSC strictures and perforation pooled rates were 4 % and 0.8 %, respectively, which are similar to those previously reported for RFA.
Conclusions Our analysis suggests that liquid nitrogen spray cryotherapy is an acceptable treatment for BE in both ablation naïve and experienced patients.
A Study of the Prognostic Significance of Platelet Distribution Width, Mean Platelet Volume, and Plateletcrit in Cerebral Venous Sinus Thrombosis
Authors: Madineni K. Usha Chowdary , Siddam Venkata Naveen Prasad , Bhuma Vengamma 
Published: July 2022

Abstract
Background Platelets play a vital role in thrombus formation and propagation and are thus implicated in the pathogenesis and morbidity of cerebral venous sinus thrombosis (CVST). A whole blood count can be used to objectively measure platelet function through platelet indices, namely platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit.
Objective This study examined how platelet indices (PDW, MPV, and plateletcrit) affect the CVST severity and functional outcome.
Methodology In this prospective, longitudinal, observational study, 66 patients with CVST from a tertiary care referral center were enrolled. A complete blood count including platelet indices was obtained using an automated hematology analyzer. Patients with and without parenchymal abnormalities on brain imaging were classified as having severe and nonsevere CVST, respectively. The modified Rankin Scale (mRS) was used to examine functional outcomes at admission and after 90 days. The patients were categorized into low mRS (0–1) and high mRS (2–6) functional groups.
Results The patients with severe CVST were older (p < 0.05) and exhibited abnormally large PDW (p < 0.05) which were statistically significant. Severe CSVT also had poor functional outcome score both at admission (p < 0.05) and 90 days later (p < 0.05) which were statistically significant. Multiple logistic regression analysis concluded age and PDW as the independent predictors of severe CVST (p < 0.05). In receiver operating characteristic curve analysis, a cut-off value of 16.5 for PDW could predict CVST severity (p < 0.05). Patients with high mRS scores at admission had significantly larger PDW. At 90 days, no association was noted between PDW and mRS scores. MPV and plateletcrit levels were similar in both the severe and nonsevere CVST groups and exerted no effect on functional outcomes. PDW was significantly and inversely related to plateletcrit (p < 0.05).
Conclusion Severe CVST and PDW had a positive correlation. During the early phases of admission, PDW levels above a particular threshold were associated with poor functional outcomes; however, no such association was observed after 90 days. MPV and plateletcrit exerted no effect on CVST severity and prognosis.
Genetic analysis of maize grain yield components and physiological determinants under contrasting nitrogen availability
Authors: Hisse Ignacio R. , D’Andrea Karina E. , Otegui María E. 
Published: July 2022

Context Most maize breeding is conducted under high-input conditions, with nitrogen supply being crucial due to its impact on yield. Aims This study aimed to investigate broad-sense heritability, and general and specific combining ability variances of physiological traits defining grain yield under contrasting soil nitrogen supply. Methods A six-parent full diallel cross was analysed under high (fertilised with 200 kg N/ha) and low (unfertilised control) nitrogen supply in two seasons. We measured kernel number per plant and kernel weight, the associated traits of plant growth during the critical and grain-filling periods, and source–sink relationships in both periods. Key results Heritabilities of traits ranged from 0.54 to 0.88, and general surpassed specific combining ability for most traits. At low nitrogen (1) the relative importance of general combining ability estimated by Baker’s ratio increased across traits (low nitrogen: 0.90 vs high: 0.85) because the decrease in combining ability variance was larger for specific than general (–78% vs −39%), and (2) source–sink relationship during grain filling had the highest Baker’s ratio (0.96) and heritability (0.78). Plant growth rates during the critical period and kernel number increased substantially at high nitrogen (40 and 34%, respectively), and they had the highest heritability (0.79 and 0.88) and Baker’s ratio (>0.90). Conclusions Low nitrogen environments increased the relative importance of general combining ability effects, and high yield can be obtained by improving the source–sink relationship during grain filling, whereas high nitrogen increased yield by improving plant growth rate during the critical period and kernel number. Implications Knowledge of source–sink relationship during effective filling period, plant growth during the critical period and kernel number may result in a more targeted selection program.
Comparison of primary gas flow standard spanning the range from 2 mL/min to 10 L/min
Authors: Chiang Chun-Lin , Wright John , Kang Woong , Chahine Khaled , Morioka Toshihiro , Krajicek Zdenek , Spazzini Pier Giorgio , Barbe Jean , Niederhauser Bernhard , Kramer Rainer , Lin Win-Ti , Lin Ying-Chun , Shaw Jiunn-Haur 
Published: July 2022

Main text
The CCM.FF-K6.2017 comparison was organised for the purpose of determination of the degree of equivalence of the national standards for low-pressure gas flow measurement over the range 2 mL/min to 10 L/min. Four molbloc-L flow elements and a molbox1+ were used as the transfer standards.
Ten laboratories from three RMOs participated between August 2017 and January 2020 - EURAMET: INRIM (Italy); LNE (France); PTB (Germany); METAS (Switzerland); CMI (Czech Republic); SIM: NIST (USA); APMP: NMIJ/AIST (Japan); KRISS (Korea); NMIA (Australia); CMS (Chinese Taipei). The measurements were provided at prescribed reference pressure and temperature conditions. All results were used in the determination of the key comparison reference value (KCRV) and the uncertainty of the KCRV. The reference value was determined at each flow separately following the procedure presented by M G Cox [1]. The degree of equivalence with the KCRV was calculated for each flow and laboratory. This KCRV can now be used in further regional comparisons.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Study of alpha particle concentration effects as the ash of deuterium-tritium fusion reaction on ignition criteria
Authors: Rajablou L , Motevalli S M , Fadaei F 
Published: July 2022

Abstract
In this study, the ignition criteria in the International Thermonuclear Experimental Reactor (ITER) associated with helium concentration is investigated. The main fuels used in this study are deuterium-tritium. Helium as the ash of deuterium-tritium reaction cannot be avoided. In this work, the effects of alpha particle concentration on plasma operation are investigated. The calculations were performed by using zero-dimensional power and particle balance equations. The results of our calculations show that the temporal evolution of alpha particle concentration becomes constant at 0.14. Then, ignition criteria and saddle points have been studied in n

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