bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life and mood status in adults with intracerebral hemorrhage: A cross-sectional study
Authors: Zhou Jie , Zhao Mingkuan , Luan Xingzhao , Yang Luxia , Xia Chengling , Sun Xifang , Jiang Lin , Yan Min , He Guangxiang , Yang Fang , Luo Qinglian 
Published: December 2022

Abstract
Background: Intracerebral hemorrhage (ICH) is the deadliest of all stroke disorders. This disease leads to a reduced quality of life for patients, with ICH survivors experiencing functional and cognitive impairment as well as chronic anxiety or depression. However, the exact correlation between patients' quality of life and anxiety symptoms and depressive symptoms remains unclear. It is also unclear whether improvements in patients' quality of life can reduce the degree of abnormal mood. The aim of this study was to investigate the correlation between quality of life, self-burden and mood status in patients with ICH to provide baseline information.
Materials and methods: This was a cross-sectional study in which 307 participants were recruited by the Department of Neurosurgery at Southwest Medical University Hospital. Data were collected through semistructured interviews with participants, patient self-assessment questionnaires, and a review of electronic medical records.
Results: There were significant correlations among quality of life, participants' self-perceived burden, anxiety symptoms and depressive symptoms (P<0.05). The analysis of the SF-36 scale showed that the physiological health of patients was the main factor affecting anxiety symptoms and depressive symptoms.
Conclusion: A decrease in the level of negative emotions in patients was associated with an increase in quality of life and a decrease in the patient's self-perceived burden.
Network pharmacology and molecular docking-based investigation on the mechanisms of action of Coptidis Rhizoma in the treatment of gastric precancerous lesions
Authors: Ye Xuxing , Xu Bin , Wang Xiaobo , Yu Guoyou , Ma Shuangshuang 
Published: December 2022

Abstract

Background Gastric precancerous lesions are a critical stage in the development of gastric cancer or gastric adenocarcinoma, and their outcome plays an important role in the malignant progression of gastric cancer. Coptidis Rhizoma has a good effect on Gastric precancerous lesions. However, its specific mechanism of action remains incompletely elucidated. Methods A network pharmacology and molecular docking techniques were used to explore the active ingredients and molecular mechanism of Coptidis Rhizoma in treating gastric precancerous lesions. The active compounds of Coptidis Rhizoma and their potential gastric precancerous lesions related targets were obtained from TCMSP, GeneCards, and OMIM databases. An interaction network based on protein-protein interactions (PPIs) was constructed to visualize the interactions between hub genes. Analysis of GO enrichment and KEGG pathway were conducted using the DAVID database. An investigation of interactions between active compounds and potential targets was carried out by molecular docking. Results A total of 11 active compounds and 95 anti gastric precancerous lesions targets of Coptidis Rhizoma were screened for analysis. GO enrichment analysis showed that the mechanism of Coptidis Rhizoma acting on precancerous gastric lesions involved in gene expression regulation and apoptosis regulation. KEGG pathway enrichment analysis showed that Coptidis Rhizoma against precancerous gastric lesions involving the MAPKsignalling pathway and PI3K/AKT signalling pathway. Molecular docking simulations indicated potential interactions between these compounds (quercetin, palmatine, berberine, berberrubine) and targets (EGFR, AKT1, MYC, TP53) involved in anti gastric precancerous lesions activity. conclusion Bioactive compounds in Coptidis Rhizoma have the potential to prevent atrophy and intestinal metaplasia.These compounds function by regulating the proteins implicated in MAPK and PI3K/AKT signalling pathways that are crucial in gastric epithelial cell differentiation, proliferation and maturation.
Effects of intercropping crops on arthropod diversity and temporal niche in apple orchard
Authors: Feng Hong-Zu , Gou Chang-Qing , Xi Lin-Qiao , Wang Lan 
Published: December 2022

Abstract
Orchard intercropping is an artificial ecological community formed by the complementary combination of tall fruit trees and low crops based. In this study, the differences and changes of arthropod diversity, richness and evenness were compared and the niche width, overlap index and competition relationship among populations in time dimension were analyzedin the apple orchards intercropping with annual crops, perennial crops, and clear tillage in Alar, China. The results showed that a large number of arthropods (97% - 99%) belonged to 7 orders, 11 families and 18 species. The relative abundanceof natural enemies in orchard intercropping crops was higher than that without intercropping, especially for Chrysoperla sinica and Adonia variegata, and that of pests was lower (except for Mirids), and especially for Aphis citricola and Lithocolletis ringoniella. Diversity analysis showed that compared to control, Shannon index and Pilu evenness index were higher in intercropping orchard , while the Simpson index was close to the control. In the three orchards, the niche widths of L. ringoniella, C. sinica, and A. variegatawere larger, while the niche widths of A. citricola and spiders were smaller. It followed that the time niche overlap index of insects with similar occurrence period was high, showing the coexistence of multiple clusters. In this study, we reported that orchard intercropping had a promoting effect on the occurrence of the insects, which not only reinforced the ecosystem service of pest regulation, but also achieved the purposes of maintaining the stability of ecosystem and protecting ecological environment.
Implications for insect conservation This study suggests that orchard intercropping has a promoting effect on the occurrence of the insects.
Investigating impact of weaknesses and strengtheners local and national factors in border cities' development: Case of study Javanrood city, Iran
Authors: Janparvar Mohsen , Ghalehteimouri Kamran Jafarpour , Mazandrani Darya , Mousavi Mirnajaf 
Published: December 2022

Abstract
Border cities face numerous development challenges, including geographical, cultural, economic, and national and regional policies. Javanrood city, located in the northwest of Kermanshah province, is one of the border cities with significant natural and human capacities and potentials to connect and shape Iran's western network with neighbouring countries. To accomplish this, an attempt has been made in this article to study the effective areas in promoting the development of the border city of Javanrood. The study of the feasibility of the scenarios, on the other hand, revealed that the assumption of "increasing the level of economic interaction" is the most effective assumption and has the greatest effect on compatibility in the scenarios, and that the assumption of "complete consideration and improvement of ways," despite being the most effective, has the least effect on compatibility in the scenarios. "The level and extent of communication channels along borders, as well as the connection of borders with interior spaces," is the key factor assumption. Therefore, the natural and human potential of Javanrood's border city is such that, if the strategy of promoting economic interactions with Iraq and the Iraqi Kurdistan region is adopted, this city can become a node city in the west of the country, develop to a large extent, and become an engine of development for other cities around it. The results show that 13 key factors are effective in promoting Javanrood development, and for these 13 factors, 51 possible and different situations were drawn, ranging from favourable to unfavourable conditions.
Readiness for Self-Directed Learning among Paramedic Students in Jordan: A Multi- Institutional Study
Authors: Alwidyan Mahmoud T. , Al-Nusour Esraa A. , Alrawashdeh Ahmad A. , Zabin Bayan S. , Omar Salim M. Bani , Abuzaid Sajeda R. , Alsatari Eman S. 
Published: December 2022

Abstract

Objectives Self-directed learning has been encouraged as an effective training method for healthcare students. This study aims to assess the level of self-directed learning readiness (SDLR) among paramedic students in Jordan and identify any associated factors. Methodology This is a cross-sectional survey using an online questionnaire on a sample of paramedic students in Jordan. All enrolled undergraduate paramedic students in the three institutions were included as potential participants. Results A total of 529 participants completed the questionnaire. The overall mean score was 141.9 (SD ± 35.5) and a total of 302 (57.1%) participants had a high level of SDLR (score > 150). Students with a high level of SDLR were more likely to be male (p = 0.039) and have high academic performance levels (p = 0.006). Conclusions This study found that even though the majority of our participants achieved a high level of SDLR, the overall mean score was among the lowest in the literature.
Association of the CD4+ /CD8+ ratio with response to PD-1 inhibitor-based combination therapy and dermatologic toxicities in patients with advanced gastric and esophageal cancer
Authors: Xu Shuangwei , Wu Lixia , Zhu Qiuwei , Zhong Yinghe , Wang Yaoyao , Wang Jingmiao , Yan Jinbi , Zhu Lina , Hang Junjie 
Published: December 2022

Abstract
Background
The host immune system affects treatment response to immune checkpoint inhibitors (ICIs) and can be reflected by circulating immune cells. The aims of this study were to evaluate whether circulating T cells are correlated with clinical response and dermatologic toxicities in patients with advanced gastric and esophageal cancer receiving PD-1 inhibitor-based combination therapy.
Methods
Patients with advanced gastric and esophageal cancer who received PD-1 inhibitor-based combination therapy (n = 203) were enrolled. Cox regression model was used to investigate independent prognostic factors, which were applied to generate a nomogram. The nomogram was validated using calibration plots and validation cohort data. Kaplan-Meier method and log-rank test were subsequently conducted to evaluate the correlation between CD4+/CD8+ ratio and OS. Additionally, correlations between CD4+/CD8+ ratio and other clinicopathological characteristics were analyzed by Pearson Chi-Square test and Continuity Correction.
Results
In the training cohort, ECOG performance status (PS), PD-L1 expression, use of antibiotics, and CD4+/CD8+ ratio were identified as independent prognostic factors. A nomogram to predict OS and survival probabilities was constructed using these factors. The nomogram showed a good discrimination ability (C-index, 0.767) and good calibration, and was externally confirmed in the validation cohort (C-index, 0.791) and test cohort (C-index, 0.784). In subgroup analysis, CD4+/CD8+ ratio was significantly correlated with OS in patients stratified by age, sex, antibiotic use, and ICI treatment line. Kaplan-Meier analysis showed that median OS in patients with a CD4+/CD8+ ratio ≥ 1.10 was 6.2 months, which was significantly shorter than those of patients with a CD4+/CD8+ ratio < 1.10 (P < 0.001). Patients with CD4+/CD8+ ratio < 1.10 had superior objective response rate (43.8% vs. 23.1%) and disease control rate (72.9% vs. 59.0%) relative to those with a ratio ≥ 1.10. In addition, PD-L1 expression, corticosteroids use, and CD4+/CD8+ ratio can predict dermatologic toxicities independently.
Conclusions
Baseline CD4+/CD8+ ratio is a potential prognostic factor for patients with advanced gastric and esophageal cancer treated with PD-1 inhibitor-based combination therapy. Nomogram incorporating CD4+/CD8+ ratio, ECOG PS at ICI initiation, PD-L1 expression, and antibiotic use can predict OS with considerable accuracy. In addition, CD4+/CD8+ ratio can predict dermatologic toxicities independently.
Clerkship length: Does it affect performance on the NBME Surgery Subject Examination across schools?
Authors: Wynne Kolu , O'Donnell Francis , Morrison Carol , Maranki Marie , Amankwah Kwame 
Published: December 2022

Abstract
Background: The optimal duration for clerkships has not yet been established. The purpose of this study was to add to the limited literature on the impact of clerkship length using data from multiple medical schools and controlling for differences in pre-clerkship achievement.
Methods: A two-way analysis of covariance (ANCOVA) was conducted to examine the effects of clerkship length reductions and school affiliation on students’ performance on the Subject Examination in Surgery.
Results: The relationship between surgery clerkship length and school performance while controlling for Step 1 scores, F (4, 1708) = 2.69, p = .030, partial η2 = .006, indicating that the effect of a clerkship length reduction on Surgery Subject Examination performance was not consistent. Further, across 91 medical schools, clerkship length was not a significant predictor of performance.
Conclusion: This study suggests that it is possible to reduce the duration of a surgery clerkship without negatively impacting student achievement.
Microbiome-metabolome interactions predict host phenotype
Authors: Shtossel Oshrit , Koren Omry , Shai Iris , Rinott Ehud , Louzoun Yoram 
Published: December 2022

Abstract
The effect of microbes on their human host is often mediated through changes in metabolite concentrations. As such, multiple tools have been proposed to predict metabolitc profiles from microbial taxa frequencies, assuming a direct relation between the gut microbiome composition and blood metabolite concentrations. However, the microbiome-metabolite relation may depend on host demographics or condition.

We show that the relation between microbiome and metabolites is best predicted at the log concentration level. We further develop LOCATE (Latent Of miCrobiome And meTabolites rElations), a machine learning (ML) tool based on latent representation which predicts the log normalized metabolites composition based on the log normalized microbiome composition. LOCATE has a higher overall accuracy than all current state-of-the-art predictors in both 16S rRNA gene and shotgun gene sequencing.

The accuracy of LOCATE and all other predictors significantly decreases when predicting on one dataset and testing on a different dataset, or on a different condition in the same dataset, especially in 16S rRNA gene sequence based data.

We propose an intermediate representation between the microbiome and the metabolite concentrations and show that this representation can be used to predict the host phenotype better than either the microbiome or the metabolome. This representation is strongly correlated with host demographics, including age, gender and diet and can be used to improve ML predictions of host phenotypes in comparison with either microbiome or metabolome using a large microbiome sample combined with a small number of metabolome samples (~ 50)
Transcriptome Analysis of Sheep IVF embryos based on single Cell RNA-Seq
Authors: Fang Di , Li Na , Zhao Jianqing , Rui Xue , Li Nan , Gao Qinghua 
Published: December 2022

Abstract
Objective: The purpose of the present study was to explore the transcriptome differences of sheep in IVF. Embryos were fertilized in vitro at different developmental stages in order to assess the differences of the function, classification and metabolic pathway of differentially expressed genes and to provide a theoretical basis for revealing the regulatory mechanism of sheep early embryo development. The experiments aimed to promote the development of sheep embryo production technology in vitro.
Methods:The single embryos derived from sheep 16-cells and morulae were produced by IVF technology as samples and the sequencing library was constructed by the Smart-Seq2 amplification technology. The transcriber was sequenced by Illumina HiSeqXten high-throughput sequencing technology and the effective sequences were analyzed by functional annotation and related bioinformatic analysis.
Results:The results indicated that the Clean reads of 16-cell and morula embryos were 47355570-50855888, of which 93.17%-94.23% reads were compared with the reference genome sequence of sheep; 10 were compared with alternative splicing types of transcription terminal site (TTS) and with the transcription start site (TSS), which accounted for the largest proportion in sheep embryo transcripts. There were 171170-211487 sites of single nucleotide polymorphisms (SNPs) and 9802-10505 sites of novel transcripts in sheep 16-cells and morulas respectively. A total of 10 genes (including novel transcripts) were expressed at the morula stage.The following screening criteria were used: | log2ratio |≥1 and Q-value < 0.05. The differences in the 17,607 DEGs between the 16-cell and morula embryos were significant (370 upregulated and 47 downregulated). From the 16-cell stage to the morula stage, 16,343 DEGs were classified and annotated. It was found that the metabolic processes of BP, CC and MF3 focused on biological functions, such as organic synthesis and nucleic acid synthesis. KEGG analysis indicated 206 pathways that were involved in the 16-cell to morula embryo stage. Two pathways were used for enrichment namely the spliceosome and the signaling pathways regulating pluripotency of stem cells, respectively.
Conclusions: The number of differentially expressed genes was identified at different stages of sheep embryo development and the function, classification and metabolic pathway of differentially expressed genes were obtained.
La cultura como fuerza configuradora y la ampliación de la base sociocultural de los agentes económicos. Una lectura para pensar abiertamente el hecho económico
Authors: Quijano Valencia Olver 
Published: December 2022

En la reflexión se presentan algunos elementos para el análisis de la economía ya no como ámbito autónomo y esfera separada de la sociedad, sino como sistema cultural y por tanto como constructo espacio/temporal e histórico, tal como pasa con las empresas, los negocios y los mercados. Con base en algunos planteamientos y contribuciones de la economía conductual, el capitalismo emocional, la antropología, la sociología y el derribamiento de las fronteras entre vida social y actividad económica, se exhorta a pensar más abiertamente el hecho económico y en el marco de una interfaz económico/cultural y multidimensional desde donde podrían superarse ciertos reduccionismos y cerramientos del análisis económico en su versión mainstream. En este horizonte, se pone en tensión la racionalidad como rasgo preponderante, determinante y determinador en la economía, las organizaciones y las decisiones de inversión en la perspectiva de ampliar la mirada y la analítica, justamente por el sinnúmero de factores que intervienen en la determinación transaccional como en la conducta de hombres y mujeres en el complejo ámbito económico
Seasonal Variations in the Chemical Composition of Essential Oil and
Antifungal and Larvicidal Activities of Marrubium vulgare, an Aromatic
Plant Growing Wild in West-Algeria
Authors: Amina Tabet Zatla , Manel Zaoui-Djelloul Daouadji , Lamia Chaoui Boudghane , El Amine Dib Mohammed 
Published: December 2022

Background:
Essential oil of M. vulgare is an important natural source that can be
useful in controlling the infection of tomatoes and larvicides.

Introduction:
This work aimed to determine seasonal variations (winter, spring and summer) of
the composition of M. vulgare essential oil and fungicidal and larvicidal potential of this oil.

Methods:
Essential oils were obtained by a Clevenger-type apparatus and analyzed by using Gas
Chromatography (GC) and Gas Chromatography Mass Spectroscopy (GC/MS). The antifungal
activities were tested on two strains: Penicillium expansum and Alternaria alternata, and insecticidal
activity was tested against Tuta absoluta insect pest of tomatoes.

Results:
The essential oil of M. vulgare, collected at the same locality throughout the three seasons
(winter, spring and summer), was compared in terms of composition and yields. Mostly quantitative,
rather than qualitative variation, was observed in the oil composition. Considerable changes
were noted for E-β-caryophyllene (4.5-23.5%), E-β-farnesene (3.4-22.9%) and α-humulene (tr-
14.8%). On the other hand, essential oil of M. vulgare collected during the months of April and
June (Col EO) was evaluated for its insecticidal and antifungal activity. Col EO showed good invitro
antifungal activity against P. expansum and A. alternata with percentages of inhibition of
94% and 100% at 10 mL/L, respectively. Due to the promising results of in-vitro tests, the essential
oil of M. vulgare was chosen to determine the protective effects in tomato fruits against infection
caused by A. alternata. Observations showed that the treatment of tomato fruits with Col EO resulted
in a remarkable reduction of disease severity compared with the controls. Col EO used with
the concentration of 0.5 mL/L air showed a very interesting protective activity against black rot of
tomatoes caused by A. alternata, up to the 15th day of storage, compared with the control. However,
essential oil collected during the month of February (FEO) exhibited no effect of antifungal
activity against the phytopathogens tested. On the other hand, the Col EO of M. vulgare exhibited
also a good insecticidal activity. At the concentration of 20 mL/L air, the oil caused mortality up
to 100% for all larval stages and adults of Tuta absoluta after 24 h of exposure.

Conclusion:
The Col EO can be used as a potential source to develop control agents to manage
some of the main pests and fungal diseases of tomato.