bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential aerosol shedding of SARS-CoV-2 Delta and Omicron variants during respiratory activities
Authors: Tham Kwok Wai , Tan Kai Sen , Ong Sean W. X. , Koh Ming Hui , Tay Douglas Jie Wen , Aw Daryl Zheng Hao , Nah Yi Wei , Abdullah Mohammed Ridzwan , Chu Justin Jang Hann , Chow Vincent , Tambyah Paul 
Published: February 2022

Abstract
Data on the viral loads in respiratory aerosols from patients infected with Delta and Omicron variants are limited. In this study, we used an exhaled breath bioaerosol collector to collect aerosol samples in coarse (> 5µm) and fine (≤ 5µm) fractions from COVID-19 patients infected with these VOCs while doing various respiratory activities. Samples were tested via SARS-CoV-2 RT-qPCR and virus culture. Nine patients (4 Delta and 5 Omicron) were included. Viral RNA was detectable in seven participants, with greater viral loads in fine aerosols. Notably SARS-CoV-2 RNA was consistently detectable in respiratory samples of all Omicron patients despite them being fully vaccinated and mostly asymptomatic in contrast with Delta patients. Singing and talking without mask generated the greatest viral loads underscoring the transmission potential of SARS-CoV-2 and its variants via respiratory aerosols. The more consistent detection of viral RNA in Omicron-infected patients may account for its greater transmissibility.
Trends and patterns of benzodiazepines prescription from 2014 to 2016: A retrospective cross-sectional study in an outpatient setting of tertiary hospital in Malaysia.
Authors: Rahman Norny Syafinaz Ab , Pakururrazi Fatin Azzyati , Zin Che Suraya , Halim Helina Abd 
Published: February 2022

Abstract
Background
Despite evidence of their association with adverse drug events and mortality, benzodiazepines are still among the main choice for treating many psychiatric disorders and neurological conditions. To date, there is a meager data on the prescribing trends and patterns of benzodiazepines in Malaysia.
Objective
This study aimed to investigate the trends and patterns of benzodiazepines prescribing at outpatient hospital setting.
Method
A retrospective, cross-sectional study was conducted at outpatient pharmacy of a tertiary hospital in Malaysia. Prescriptions for any of seven benzodiazepines (alprazolam, bromazepam, clobazam, clonazepam, diazepam, lorazepam and midazolam) issued from January 2014 until December 2016 were screened and included in this study. Trends and patterns of prescribed benzodiazepines were examined. Descriptive statistics and association between patient characteristics and prescribing patterns were performed using STATA® SE v.13.1 (Stata Corp LP, Texas, USA).
Results
A total of 5,728 benzodiazepines prescriptions of the seven benzodiazepines were prescribed for 1,943 patients from 2014 to 2016. BZDs were prescribed to 1,013 (52.1%) male with mean age of 46.8 ± 14.1 for the whole study population, in which 26.8% were between 45–54 years old. About 40% of benzodiazepines prescribed were classified as short-acting. About 12.6% reduction in the overall number of benzodiazepine prescriptions from 2014 (n = 1956) to 2016 (n = 1709). Alprazolam was the most frequently prescribed (43.3%) in 2014, followed by (38.9%) 2015 and (36.8%) 2016. Approximately, 69.64% (n = 6,218) of benzodiazepines were prescribed for a duration of 15 to 30 days, while 57.29% (n = 5,115) of benzodiazepines were prescribed with fixed dosing schedule.
Conclusion
Overall benzodiazepine prescription shows a decreasing trend from 2014 to 2016. Alprazolam, the short-acting benzodiazepine was the most frequently prescribed in hospital outpatient setting in Malaysia.
BRAVEHeart: A randomised trial comparing the accuracy of Breathe Well and RPM for deep inspiration breath hold breast cancer radiotherapy
Authors: Byrne Hilary , Steiner Elisabeth , Booth Jeremy , Lamoury Gillian , Morgia Marita , Richardson Kylie , Ambrose Leigh , Makhija Kuldeep , Stanton Cameron , Zwan Ben , Atyeo John , Silvester Shona , Plant Natalie , Keall Paul 
Published: February 2022

Abstract
Background: Deep inspiration breath hold (DIBH) reduces radiotherapy cardiac dose for left-sided breast cancer patients. The BRAVEHeart (Breast Radiotherapy Audio Visual Enhancement for sparing the Heart) trial will assess the accuracy and usability of a novel device, Breathe Well, for DIBH guidance for left-sided breast cancer patients. Breathe Well will be compared to an adapted widely available monitoring system, the Real-time Position Monitoring system (RPM).Methods: BRAVEHeart is a single institution prospective randomised trial of two DIBH devices. BRAVEHeart will assess the DIBH accuracy for Breathe Well and RPM during left-sided breast cancer radiotherapy. After informed consent has been obtained, 40 patients will be randomised into two equal groups, the experimental arm (Breathe Well) and the control arm (RPM with in-house modification of an added patient screen). The primary hypothesis of BRAVEHeart is that the accuracy of Breathe Well in maintaining the position of the chest during DIBH is superior to the RPM system. Accuracy will be measured by comparing chest wall motion extracted from images acquired of the treatment field during breast radiotherapy for patients treated using the Breathe Well system and those using the RPM system.Discussion: The Breathe Well device uses a depth camera to monitor the chest surface while the RPM system monitors a block on the patient abdomen. The hypothesis of this trial is that the chest surface is a better surrogate for the internal chest wall motion used as a measure of treatment accuracy. The Breathe Well device aims to deliver an easy to use implementation of surface monitoring. The findings from the study will help inform the technology choice for other centres performing DIBH.Trial registration: This trial was registered on ClinicalTrials.gov on 26 August 2016. The identifier is: NCT02881203. (https://clinicaltrials.gov/ct2/show/NCT02881203).
La pareja y su terapeuta. Conceptualizaciones, evoluciones y desafíos
Authors: González Quiros Deisy , Ramírez Gómez Daniela , Sepúlveda Flórez Cindy 
Published: February 2022

El presente artículo se deriva de una investigación documental, la cual tuvo como objetivo analizar el concepto de pareja y las habilidades del terapeuta de pareja, que se identificaron en fuentes documentales de terapia contemporánea. En primer lugar, se logró identificar los cambios que se han dado en la conceptualización de la pareja, ya que la pareja como concepto ha tenido una fuerte implicación histórica y cultural, evidenciándose nuevas tipologías de pareja en la contemporaneidad. También fue posible encontrar que la pareja ha sido leída como sistema desde el trabajo terapéutico con la influencia de la cibernética de segundo orden. En segundo lugar, se hallaron algunas de las habilidades que un terapeuta de pareja debe desarrollar para el éxito de su intervención, entre las que se encuentran la identificación de motivo de consulta, el establecimiento de la alianza terapéutica y el desarrollo del self del terapeuta.
Economic impacts of water market simulation in agriculture
Authors: Nourani Leyla , Moosavi Seyed Nematolla , Shirvanian Abdoulrasool 
Published: February 2022

Abstract
Water market is one of the modern issues in demand management in face of water scarcity, which is increasingly used in different parts of the world as a tool for optimal allocation of water consumption and transfer of water to consumers with higher final efficiency. Despite the benefits of forming a water market, such markets are not yet developed in developing countries, such as Iran. Accordingly, this study examines the economic impact of water market design on farmers’ livelihood in Iran. The data of this study were collected using a multistage random sampling method from 100 users with water rights in the irrigation network of Ramjerd plain in Fars province. The data were analyzed using positive mathematical programming and scenario making. The results showed that with the formation of the water market, the gross margin of the total lands with irrigation network of Ramjerd plain increased from 2,013.080 billion Rials to 2,194.2200 billion Rials. As a result, the agricultural economic situation of the region experienced an increase of 9%. therefore an appropriate legal and regulatory structure is recommended to create a water market on the lands located within the irrigation networks.
Establishing a statistical relation between meteorological and hydrological drought indices
Authors: Jincy Rose M. A. , Chithra N. R. 
Published: February 2022

Abstract
Investigation of the hydrological drought behaviour of the Bharathapuzha river basin of Kerala, India, on account of the meteorological drought condition of the watershed was carried out in this study with the aid of four popular drought indices. Statistical relations were established between the indices using polynomial regression models to help in predictions. A study on the decadal spatial variation of hydrological drought behaviour over the basin was also conducted. The cross-correlation study was also performed to understand the propagation of hydrological drought in the event of meteorological drought. The results reveal a slight decrease in the spatial extent of hydrological drought over time. The correlation between meteorological and hydrological drought indices was found to be more assertive at grid locations G1 and G4. According to the findings, the strongest correlation of 0.8 in the propagation of meteorological to hydrological drought was observed at a lag of 3 months over a 12 -month timescale. Run theory reveals that the river basin is subjected to hydrological drought over 54–65% of the months in the historic period. Regression analysis suggests that the cubic model outperforms the other models.
Long Non-Coding RNAs and Obesity: New Potential Pathogenic Biomarkers
Authors: Fontanini Martina , Cabiati Manuela , Giacomarra Manuel , Federico Giovanni , Del Ry Silvia 
Published: February 2022

Background:
A portion of the human genome is characterized by long non-coding RNAs
(lncRNAs), a class of non-coding RNA longer than 200 nucleotides. Recently, the development of new biomolecular
methods made it possible to delineate the involvement of lncRNAs in the regulation of different biological
processes, both physiological and pathological, by acting within the cell with different regulatory mechanisms
based on their specific target. To date, obesity is one of the most important health problems spreading
all over the world, including the children: the search for new potential early biomarkers could open the doors to
novel therapeutic strategies useful to fight the disease early in life and to reduce the risk of obesity-related
co-morbidities.

Objective:
This review highlights the lncRNAs involved in obesity, in adipogenesis, and lipid metabolism, particularly
in lipogenesis.

Conclusion:
LncRNAs involved in adipogenesis and lipogenesis, being at the cross-road of obesity, should be
deeply analysed in this contest, allowing to understand possible causative actions in starting obesity and whether
they might be helpful to treat obesity.
Structural Biology Meets Biomolecular Networks: The Post-AlphaFold
Era
Authors: Yan Wenying , Hu Guang 
Published: February 2022

Background:
Recent progress in protein structure prediction by AlphaFold has opened new
avenues to decipher biological functions from the perspective of structural biology based on the proteomics
level.

Methods:
To meet these challenges, in this perspective, three scales of networks for protein structures,
including structural protein-protein networks, protein structural networks, and elastic network models
were introduced for high-throughput modeling of protein functional sites and protein dynamics.

Conclusion:
In the post-AlphaFold era, it is assumed that the integration of biomolecular networks may
be leveraged in the future to develop a modeling framework that addresses protein structure-based functions
with the application in drug discovery.
Propofol and Sevoflurane Alleviate Malignant Biological Behavior and Cisplatin
Resistance of Xuanwei Lung Adenocarcinoma by Modulating the Wnt/β-catenin
Pathway and PI3K/AKT Pathway
Authors: Wang Zhonghui , Quan Yuhang , Li Shanshan , Wang Yahong , Liu Guangshun , Lv Zhiyong 
Published: February 2022

Background:
Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent
tumor development. The prevalence of lung adenocarcinoma in China is highest in Yunnan Xuanwei, and many
patients with lung cancer in this area are often resistant to platinum-based treatments.

Objective:
The objective of the study was to investigate the effects of propofol and sevoflurane on malignant biological
behavior and cisplatin resistance of Xuanwei lung adenocarcinoma.

Methods:
Herein, XWLC-05/R, a cisplatin-resistant cell line of XWLC-05 cells from Xuanwei lung adenocarcinoma,
was constructed. The XWLC-05 cells and XWLC-05/R cells were treated with propofol and sevoflurane singly or as a
combination and subjected to CCK-8 assay, clone formation tests, and flow cytometry analysis to assess the proliferation
level of cells. The morphology and number of apoptotic bodies in XWLC-05 cells and XWLC-05/R were examined
with a transmission electron microscope. The ANNEXIN V-FITC/PI and transwell assays were performed to
evaluate apoptosis, invasion, and migration of the cells. Subsequently, we constructed a Xuanwei lung adenocarcinoma
xenograft model to investigate the effects of propofol and sevoflurane on the tumorigenicity of XWLC-05 cells in vivo.

Results:
Treatment with propofol and sevoflurane significantly inhibited proliferation, invasion, migration, and induced
apoptosis of XWLC-05 and XWLC-05/R cells. These effects were more pronounced when propofol and
sevoflurane were co-incubated with the cells. Moreover, both propofol and sevoflurane significantly inhibited Wnt/β-
catenin and PI3K/AKT pathways. Moreover, the two drugs effects suppressed the malignant biological behavior of
XWLC-05 cells and XWLC-05/R cells, and this effect was counteracted by 740Y-P (PI3K/AKT pathway activator)
and Wnt pathway activator 1 (Wnt/β-catenin pathway activator). In vivo experiments confirmed that propofol and
sevoflurane alleviated the tumorigenicity of XWLC-05 cells.

Conclusions:
In summary, this study shows, for the first time, that propofol and sevoflurane decrease the proliferation,
invasion, migration and induce apoptosis of XWLC-05 cells and XWLC-05/R cells by impeding the Wnt/β-catenin and
PI3K/AKT signaling pathways, thereby alleviating the development of Xuanwei lung adenocarcinoma in vivo. Moreover,
these effects are more pronounced when the two drugs are combined.
FORMAÇÃO DE PROFESSORES PARA DOCÊNCIA ONLINE: CONSIDERAÇÕES SOBRE UM ESTUDO DE CASO
Authors: Silva Marco , Cilento Sheilane Avellar 
Published: February 2022

No Brasil, cresce exponencialmente a oferta de graduações na modalidade online, na medida em que a legislação oficial específica e as políticas públicas de inclusão social no ensino superior contam com as tecnologias digitais invadindo os mais distintos setores da vida social. No entanto, a expansão da modalidade onlinenão tem sido acompanhada de formação docente adequada, particularmente entre os graduandos em pedagogia e aqueles professores que atuam em cursos na web. Este texto reúne algumas considerações sobre formação de professores para docência onlineextraídas de investigação acadêmica realizada com base no estudo de um caso brasileiro. O quadro teórico articula abordagens sobre: a) educação e cultura digital; b) docência no ensino superior; e c) formação para a docência online. As conclusões apontam para a necessidade de: a) desenvolver saberes docentes que contemplem a especificidades do meio online; b) desenvolver o diálogo entre professores e alunos enquanto parceiros que compartilham a construção do conhecimento e da comunicação; c) superar o uso das interfaces fórum e chat baseado na interação sem articulação, em favor da colaboração e interatividade; d) investir na formação continuada que proporcione ao docente aptidões pedagógicas específicas como expressão socioafetiva nas relações interpessoais com os cursistas e expertisetecnológica para promover a inclusão do cursista na dinâmica específica da aprendizagem online. Focado nesses desafios, o texto espera contribuir com o debate sobre a qualidade da formação de professores para docência online, quando a tendência ainda é a subutilização das potencialidades interativas da webe a reprodução de práticas unidirecionais da sala de aula presencial.
Pengaruh Model Pembelajaran Inquiri Terbimbing dan Pemahaman Konsep Terhadap Kemampuan Pemecahan Masalah siswa SMP Negeri 6 Kerinci
Authors: Mustika Meri , Asra Revis , Anggereini Evita 
Published: February 2022

This study aims to determine (1) the effect of the Guided Inquiry learning model on students' problem-solving abilities; (2) the effect of Concept Understanding level on students' Problem Solving Ability; (3) the interaction between the Guided Inquiry learning model and the level of Concept Understanding on students' Problem Solving Ability. This study uses a Quasi Experimental Design with a pretest-posttest Control Group Design model. The population in this study was class VII SMP Negeri 6 Kerinci. The sample uses probability sampling which includes random sampling. To collect the data used is a test of problem solving skills, tests of understanding the concept and documentation. Data analysis used Two-Way Anova.

ABSTRAK
Penelitian ini bertujuan untuk mengetahui (1) pengaruh model pembelajaran Inquiri Terbimbing terhadap Kemampuan Pemecahan Masalah siswa; (2) pengaruh tingkat Pemahaman Konsep terhadap Kemampuan Pemecahan Masalah siswa; (3) interaksi antara model pembelajaran Inquiri Terbimbing dengan tingkat Pemahaman Konsep terhadap Kemampuan Pemecahan Masalah siswa. Penelitian ini menggunakan Quasi Eksperimental Design dengan model pretest-posttest Control Group Design. Populasi pada penelitian ini adalah kelas VII SMP Negeri 6 Kerinci. Sampelnya menggunakan probability Sampling yang meliputi Random Sampling. Untuk mengumpulkan data yang digunakan adalah tes kemampuan pemecahan masalah, tes pemahaman konsep serta dokumentasi. Analisis data yang digunakan Anava Dua Arah.
Berdasarkan hasil penelitian dapat disimpulkan bahwa: 1) Model pembelajaran Inquiri terbimbing berpengaruh terhadap kemampuan pemecahan masalah siswa kelas VII SMP Negeri 6 Kerinci; 2) Pemahaman konsep tidak berpengaruh terhadap kemampuan pemecahan masalah siswa. kelas VII SMP Negeri 6 Kerinci; serta 3) Terdapat interaksi antara model pembelajaran Inquiri terbimbing dengan pemahaman konsep terhadap kemampuan pemecahan masalah siswa kelas VII SMP Negeri 6 Kerinci.
Studi Literatur: Pengaruh Penerapan Model Pembelajaran Kooperatif Tipe Make a Match Terhadap Kompetensi Belajar Peserta Didik
Authors: Taufik Wirda , Helendra Helendra , Syamsurizal Syamsurizal , Alberida Heffi 
Published: February 2022

This study aims to examine the effect of the application of the make a match type of cooperative learning model on the learning competence of students. This study uses a systematic review method by reviewing several scientific articles that are relevant to the author's research. The data used in this study were obtained from scientific articles that are relevant to the problems discussed by the author. This data is taken from databases such as SINTA, Google Schoolar, and other relevant journal sites. The variables used in this study were the cooperative learning model of the make a match type (independent variable) and the learning competence of students (dependent variable). The results of this study indicate that the learning competencies (knowledge, attitudes, and skills) of students have increased after the application of the make a match type of cooperative learning model at all school levels starting from elementary, junior high, and high school. Thus, the research results are expected to strengthen and summarize the results of research related to the make a match learning model. The implications of the results of this study can be a consideration for teachers to raise the spirit of learning in students by applying the make a match learning model so that their learning competence will also increase.
Abstrak. Penelitian ini bertujuan untuk mengkaji tentang pengaruh dari penerapan model pembelajaran kooperatif tipe make a match terhadap kompetensi belajar peserta didik. Penelitian ini menggunakan metode systematic review dengan mereview beberapa artikel ilmiah yang relevan dengan penelitian penulis. Data yang digunakan dalam penelitian ini diperoleh dari artikel ilmiah yang relevan dengan permasalahan yang dibahas oleh penulis. Data ini diambil dari database seperti SINTA, Google Schoolar, dan situs jurnal lainnya yang relevan. Variabel yang digunakan dalam penelitian ini adalah model pembelajaran kooperatif tipe make a match (variabel bebas) dan kompetensi belajar peserta didik (variabel terikat). Hasil penelitian ini menunjukkan bahwa kompetensi belajar (pengetahuan, sikap, dan keterampilan) peserta didik mengalami peningkatan setelah penerapan model pembelajaran kooperatif tipe make a match di semua tingkatan sekolah mulai dari SD, SMP, dan SMA. Jadi model pembelajaran kooperatif tipe make a match ini memberikan pengaruh yang positif terhadap kompetensi belajar peserta didik. Dengan demikian, model pembelajaran make a match ini bisa menjadi pertimbangan oleh guru untuk membangkitkan kembali semangat belajar peserta didik sehingga kompetensi belajarnya juga akan meningkat.