bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of new predictive equations for resting energy expenditure in physically active boys
Authors: Łuszczki Edyta , Jagielski Paweł , Bartosiewicz Anna , Dereń Katarzyna , Matłosz Piotr , Kuchciak Maciej , Oleksy Łukasz , Stolarczyk Artur , Mazur Artur 
Published: October 2022

Abstract
Measurement or estimation of resting energy expenditure (REE) should be the first step in determining energy demand in physically active boys. The purpose of this study was to develop and validate new equations for resting energy expenditure in male children and adolescents practicing football. The study was carried out among 184 boys in the validation group and 148 boys in the cross-validation group (mean age 13.20 years and 13.24 years, respectively). The calorimeter and device for assessing body composition by bioelectrical impedance analysis (BIA) were used. Model of multiple regression showed that REE can be predicted in this population with equations 1 or 2. Predictive Eq. 1 had an average error of 51 ± 199 kcal and predictive Eq. 2–39 ± 193 kcal. Cohen's d coefficient was 0.2, which confirms the small difference. The bias was 4.7% and 3.9%, respectively. The accuracy was 61.2% in the population for predictive Eqs. 1 and 66.2% for predictive Eq. 2. Therefore, the new formulas developed and validated in this study are recommended for the estimation of REE in physically active boys, when the use of in-direct calorimetry is not feasible or available.
Igniting Growth Surges: Lessons from the Past
Authors: Atsebi Jean-Marc B. 
Published: October 2022

Abstract
``What, exactly" can countries do to initiate an episode of growth surge? I identify 132 episodes of growth surges in 117 countries over the period 1980-2010. I find that disproportionate improvements in macroeconomic stability and external factors and endowments favor a higher probability of growth surge. They are followed by structural reforms, investments, labor and productivity, trade diversification and quality, and lastly by institutions. Countries can maximize the likelihood of igniting growth surges if they jointly achieve significant improvements in macroeconomic stability and external conditions and endowments. Also, macroeconomic stability, and to some extent, external factors and endowments may be considered as dominant strategies to ignite a growth surge, as no improvements in these determinants, generally constraint the other determinants to have a smaller effect on growth surges. There is a notable difference between decades, regions, and levels of development, which calls for careful tailoring of policies aiming at igniting growth surges to local conditions.
JEL Classification: O11 , O47 , F43 , E65
Mortality in Patients with Schizophrenia in Japan
Authors: Nomura Nobuyuki , Misawa Fuminari , Fujii Yasuo , Takeuchi Hiroyoshi 
Published: October 2022

Abstract
Purpose: Patients with schizophrenia have a higher mortality risk than the general population. However, no recent studies have investigated mortality in people with schizophrenia in Japan. Therefore, we conducted a retrospective study to evaluate excess mortalityand risk factors for mortality in patients with schizophrenia in Japan.
Methods: We included patients diagnosed with schizophrenia or schizoaffective disorder at Yamanashi Prefectural Kita Hospital between January 1, 2013, and December 31, 2017. Standardized mortality ratios were used to compare mortality rates between patients with schizophrenia and the general population. Logistic regression analysis was performed to estimate risk factors associated with mortality.
Results: Of the 1,699 patients with schizophrenia (893 men and 806 women), 104 (55 men and 49 women) died during the study period. The all-cause standardized mortality ratio (95% confidential interval [CI]) was 2.25 (1.81–2.68); the natural- and unnatural-cause standardized mortality ratios were 2.09 (1.64–2.54) and 4.68 (2.63–6.74), respectively. Male sex (odds ratio [OR] = 2.24, 95% CI = 1.10–4.56), age (OR = 1.12, 95% CI = 1.09–1.16), and barbiturate use (OR = 8.17, 95% CI = 2.07–32.32) were associated with a high risk of mortality.
Conclusion: The mortality rate remains high in patients with schizophrenia in Japan. Further studies are needed to evaluate mortality trends in this population.
Supply and Demand Determinants of Heterogeneous VAT Pass-Through
Authors: Bellon Matthieu , Copestake Alexander 
Published: October 2022

Abstract
We investigate the substantial variation in the extent to which a rise in value-added tax (VAT) is passed on to consumers. We first extend existing theory to characterize the roles of imperfect competition and product differentiation, then investigate these relationships empirically using a panel of 14 Eurozone countries between 1999 and 2013. We find that consumers pay a larger share of VAT increases when producers face more competitive upstream markets: the higher tax reduces final demand, but this lower demand does not in turn reduce input prices when upstream markets are competitive. Greater scope for quality differentiation also increases pass-through, by reducing the relative price elasticity of demand.
JEL: D43, H22, H25
1H, 13C, and 15N assignments of the mRNA binding protein hnRNP A18
Authors: Coburn Katherine M. , Roth Braden , Varney Kristen M. , Carrier France , Weber David J. 
Published: October 2022

Abstract
Heterogeneous ribonuclear protein A18 (hnRNP A18) is an RNA binding protein (RBP) involved in the hypoxic cellular stress response and regulation of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) expression in melanoma, breast cancer, prostate cancer, and colon cancer solid tumors. hnRNP A18 is comprised of an N-terminal structured RNA recognition motif (RMM) and a C-terminal intrinsically disordered domain (IDD). Upon cellar stressors, such as UV and hypoxia, hnRNP A18 is phosphorylated by casein kinase 2 (CK2) and glycogen synthase kinase 3β (GSK-3β). After phosphorylation, hnRNP A18 translocates from the nucleus to the cytosol where it interacts with pro-survival mRNA transcripts for proteins such as hypoxia inducible factor 1α and CTLA-4. Both the hypoxic cellular response and modulation of immune checkpoints by cancer cells promote chemoradiation resistance and metastasis. In this study, the 1H, 13C, and 15N backbone and sidechain resonances of the 172 amino acid hnRNP A18 were assigned sequence-specifically and provide a framework for future NMR-based drug discovery studies toward targeting hnRNP A18. These data will also enable the investigation of the dynamic structural changes within the IDD of hnRNP A18 upon phosphorylation by CK2 and GSK-3β to provide critical insight into the structure and function of IDDs.
School of Rocks: A Transmission Time Investment Model for Pleistocene Lithic Technology
Authors: Kovach Tanner Z. , Gill Jayson P. 
Published: October 2022

Abstract
We propose a transmission time investment model for integrating the tenets of human behavioral ecology and cultural evolutionary theory to investigate agency and optimality in the social transmission of lithic technologies. While the cultural transmission process is often overlooked in discussions of optimality, we view it as a critical area for the application of adaptive reasoning to further understand the mechanisms responsible for change in lithic technologies. The proposed model modifies a technological intensification model based on the marginal value theorem (Bettinger et al., 2006; Mohlenhoff and Codding, 2017) to explore how transmissibility may have affected the complexity of socially transmitted lithic production systems during the Pleistocene. This transmission investment model is contrasted with a passive demographic model derived from traditional explanations for changes in lithic technologies. To highlight how optimal considerations of transmissibility may have affected the long-term evolution of lithic technologies, we apply this model to three Pleistocene archaeological case studies investigating increases and decreases in lithic technological complexity. We propose that changes in each of these cases can be understood as the result of time management strategies related to the social transmission process.
Rainfall Nowcasting asing a Bayesian framework and Long Short-Term Memory Multi-model Estimation. Case of study: Andean Ecuadorian Tropical City
Authors: Cabrera Diego , Quinteros María , Cerrada Mariela , Sánchez René-Vinicio , Guallpa Mario , Sancho Fernando , Li Chuan 
Published: October 2022

Abstract
Rainfall nowcasting is a challenging task due to the time-dependencies of the variables and the stochastic behavior of the process. The difficulty increases when the geographic area of interest is characterized by a large spatio-temporal variability of its meteorological variables, causing large variations of rainfall even within a small area in places such as the Tropical Andes. To address this problem, we propose a methodology for building a group of models based on Long Short-Term Memory (LSTM) neural networks using Bayesian optimization. We optimize the model hyperparameters using accumulated experience to reduce the hyperparameter search space over successive iterations. The result is a large reduction in modeling time that allows the building of specialized LSTM models for each zone and nowcasting time. We evaluated the method by nowcasting rain events in the urban area of Cuenca City in Ecuador, a city with large spatio-temporal variability. The results show that our proposed model offers better performance over the trivial forecaster for up to 9 hours of future forecasts with an accuracy of up to 84.4%
Effect of alkaline delignification process on the anatomical characteristics and some mechanical properties of tropical woods of different densities
Authors: Maturana Juan. Carlos. , Arroyave Catalina , Hurtado Alejandro , Echeverría Félix. , Correa Esteban 
Published: October 2022

Abstract
Wood delignification is a straightforward process of great interest in the development of advanced materials and products for sustainable applications. This process can reduce the stiffness of the wood cell wall by using selective chemical reagents that remove lignin/hemicellulose and thus facilitate its modification in combination with other treatments. This study aimed to compare the efficiency and uniformity of the partial delignification process using the sodium hydroxide and sodium sulfite (NaOH/Na2SO3) mixed aqueous solution in the three hardwood species Brosimum utile (Sande), Carapa guianensis (Andiroba), and Dipteryx oleifera (Choiba). These are important tropical tree species, providing essential material for the wood industry. The effects and distribution of the solution were studied based on the variations exhibited by the center and ends of the delignified woods, using chemical composition analysis techniques, FT-IR spectra, optical microscopy, and scanning electron microscopy (SEM). The process allows the partial chemical removal of lignin/hemicellulose in different non-uniform proportions between the center and the ends of the woods under study. The lignin/hemicellulose removal ratios varied widely between the different wood species. The density of delignified wood did not vary significantly after treatment. The modulus of rupture (MOR) and modulus of elasticity (MOE) of delignified wood decreased. The results suggested that denser tropical wood requires the adjustment of the process variables while the proposed method can treat less dense tropical woods. Partially delignified tropical hardwood can be used to develop advanced materials and products for diverse applications.
Biosynthesis of polyene antibiotics and sterols under the action of exogenous β-sitosterol by Streptomyces netropsis IMV Ac-5025
Authors: Loboda Mariia , Biliavska Liudmyla 
Published: October 2022

Abstract
Unexplained aspects of the biosynthetic capacity of Streptomyces netropsis IMV Ac-5025 were studied. Correlations in the biosynthesis of polyene antibiotics with other biological active substance by the producer were found for the first time. Exogenous β-sitosterol caused an increase of polyene antibiotics biosynthesis and their excretion from the cells into culture liquid. Their sum was raised 4.5-fold in biomass and 2.5-fold in culture liquid under the action of 10 µg/mL of β-sitosterol. Biomass accumulation was almost doubled under the action of 5 µg/mL of exogenous substance in the synthetic nutrient medium and 1.5-fold – in organic. Squalene, ergosterol, cholesterol, stigmasterol, β-sitosterol, and 24-epibrasinolide were accumulated in producer cells. Their sum was ranged from 1.753 to 4.750 mg/g ADB and was increased 2.7-fold under the action of 0.25 µg/mL of β-sitosterol. These results are important for understanding the complex relationships of metabolic pathways in streptomycetes cells.
Clinical and sonographic improvement of developmental dysplasia of the hip: Analysis of 948 patients
Authors: Lankinen Vilma , Bakti Karim , Helminen Mika , Väli-Pakka Jarmo , Laivuori Hannele , Hyvarinen Anna 
Published: October 2022

Abstract
Background
Developmental dysplasia of the hip is a common condition, which varies in severity. Abduction treatment is widely used to correct the development of the hips, but mild forms of DDH can also recover spontaneously. The purpose of this study was to evaluate factors affecting the rate of improvement of developmental dysplasia of the hip, and evaluate any risk factors slowing the process.
Material and methods
The study population consisted of patients diagnosed with DDH in Tampere University hospital in the years 1998–2018. Data was retrospectively collected and associations between clinical variables and rate of improvement was analyzed. Alpha angles were assessed monthly and associations between risk factors and improvement of alpha angles were studied. Total of 948 patients were included in the analysis.
Results
More sever first status of the hips was associated with faster improvement in dynamic ultrasound compared to milder DDH in univariate design in first 3 months of age, in the multivariable design Ortolani positivity was conversely associated with lower alpha angles in 1-month follow-up. Immediate abduction treatment was associated with faster recovery rate compared to delayed abduction or watchful waiting. Female sex and positive family history were associated with slower rate of improvement and lower alpha angles. In multivariable design, female sex, positive family history and treatment strategy remained statistically significant as initiation time of the treatment explained the first found association of clinical hip status and the recovery rate after 2 months of age.
Conclusion
Female sex and positive family history might be independent risk factors for slower recovery in DDH before six months of age. These children might need special attention in their follow-up plans and abduction treatment.
Analysis of Google Trends and Search Results for Ophthalmic Symptoms of Monkeypox
Authors: Zhu Aretha , Mahajan Jasmine , Oydanich Marko K. , Luo Michael C. , Khouri Albert S. 
Published: October 2022

Abstract
Purpose: In late July, the World Health Organization (WHO) declared monkeypox virus’s global spread as a “public health emergency of international concern.” About a quarter of monkeypox cases feature ophthalmic symptoms. We assessed trends of public interest in monkeypox ophthalmic involvement and inclusion in online search engine queries.
Methods:The following keywords were searched on Google Trends from April 1, 2022 to August 12, 2022: monkeypox + eye, pink eye, eye infection, eyelid, vision, blurry vision, vision loss, blindness, eye symptoms, eye problems, eye pain, eye redness, conjunctivitis, conjunctiva, cornea, keratitis, corneal ulcer, and blepharitis. We analyzed trends, correlation with case count data, and comparison with popularity of non-ophthalmic symptoms via Student’s t-test. Inclusion of ophthalmic symptoms in Google search results for “monkeypox symptoms” was assessed.
Results: “Monkeypox eye” had the highest average interest worldwide and in the United States. Search interest peaked in mid-May and late July 2022. When compared to interest in “monkeypox rash,” the most popular searched monkeypox symptom, the average interest of “monkeypox eye” was lower (p<0.01). Of the first 50 results from the Google search of “monkeypox symptoms,” 10/50 (20%) mentioned ophthalmic symptoms. 6/50 (12%) mentioned the eye as a route of virus transmission.
Conclusion: Public interest in monkeypox ophthalmic symptoms corresponds with geographic and temporal trends, i.e., timing and location of the first reported non-endemic cases and WHO announcement. Although ophthalmic symptoms are not as widely searched currently, inclusion in public health messaging is key for diagnosis, appropriate management, and reduction of further transmission.
Thermal Analysis and Phase Equilibria of the Molten System Na3AlF6 – NdF3 – Nd2O3
Authors: Krishnan Dhiya , Korenko Michal , Šimko František , Kubíková Blanka , Rakhmatullin Aydar 
Published: October 2022

Abstract
Phase diagrams of the systems Na3AlF6 – NdF3 and (Na3AlF6 – NdF3)eut – Nd2O3 were experimentally determined by thermal analysis up to 60 mol % of NdF3, and 45 mol % of Nd2O3, respectively. The Na3AlF6 – NdF3 system was found to be a simple eutectic system with the eutectic point with the following approximate coordinates: 49 mol % NdF3, and 905°C. This eutectic composition was then used for the thermal analysis of the (Na3AlF6 – NdF3)eut – Nd2O3 system. The coordinates of the eutectic point of the (Na3AlF6 – NdF3)eut – Nd2O3 system were found to be at approximately 46 mol % Nd2O3 and 733°C. After the thermal analysis, the X – ray diffraction analysis of the solidified samples of both systems was performed. The XRD analysis of the Na3AlF6 – NdF3 system has shown the formation of two new compounds; NaNdF4 and NdOF. The formation of NdOF is probably the product of the high temperature hydrolysis between the moisture in the atmosphere and NdF3. The XRD analysis of the solidified samples of the (Na3AlF6 – NdF3)eut – Nd2O3 system has shown the formation of the following new compounds; NaNdF4, NdOF, NdAlO3, and NaF.
Revealing a Solar Cycle Resonance through tree-rings
Authors: Khorchani Ali , Touhami Issam , Elaieb Mohamed Tahar , Khaldi Abdelhamid 
Published: October 2022

Abstract
Tree-ring data is one of the best proxy sources for studying the dynamics of the Earth’s climate system. However, paleoclimatic studies often face multiple problems that can influence the quality of the obtained information. The success in analyzing these proxies is thus crucial for understanding the nature of these dynamics. Here we introduce a new data-driven approach that facilitates the detection and extraction of cyclic components from tree-ring time series. To this end, we firstly tested this approach on artificial time series then we applied it on over 6000 tree-ring time series collected from 242 sites and 66 tree-species around the world. Based on the use of the autocorrelation functon(ACF) analysis and a consecutive filtering, the decomposition of the tree-ring time series revealed the existence of 8 harmonic modes (HMs) of cyclicity. We found that cyclicity inherent in tree-ring time series follows two resonance processes. Furthermore, an assumption model explaining the relationship between these different harmonic modes and which corroborated well with the extracted cycles was also introduced. The consistency of the achieved data among the widely separated sites as well as the spectacular accuracy of our findings compared to different studies give evidence to assign these 8 HMs as a truly global signature. Our analysis suggests that this global signature is related to the resonance of the solar activity given the very close relationship found between these HMs and the solar cycle. The resonance process, demonstrated by our study could be of great importance for earth-climate system and solar dynamo theories.
Experiences Among Patients With Cystic Fibrosis in the MucoExocet Study of Using Connected Devices for the Management of Pulmonary Exacerbations: Grounded Theory Qualitative Research
Authors: Morsa Maxime , Perrin Amélie , David Valérie , Rault Gilles , Le Roux Enora , Alberti Corinne , Gagnayre Rémi , Pougheon Bertrand Dominique 
Published: October 2022

Background
Early detection of pulmonary exacerbations (PEx) in patients with cystic fibrosis is important to quickly trigger treatment and reduce respiratory damage. An intervention was designed in the frame of the MucoExocet research study providing patients with cystic fibrosis with connected devices and educating them to detect and react to their early signs of PEx.

Objective
This study aims to identify the contributions and conditions of home monitoring in relation to their care teams from the users’ point of view to detect PEx early and treat it. This study focused on the patients’ experiences as the first and main users of home monitoring.

Methods
A qualitative study was conducted to explore patients’ and professionals’ experiences with the intervention. We interviewed patients who completed the 2-year study using semistructured guides and conducted focus groups with the care teams. All the interviews were recorded and transcribed verbatim. Their educational material was collected. A grounded analysis was conducted by 2 researchers.

Results
A total of 20 patients completed the study. Three main categories emerged from the patients’ verbatim transcripts and were also found in those of the professionals: (1) task technology fit, reflecting reliability, ease of use, accuracy of data, and support of the technology; (2) patient empowerment through technology, grouping patients’ learnings, validation of their perception of exacerbation, assessment of treatment efficacy, awareness of healthy behaviors, and ability to react to PEx signs in relation to their care team; (3) use, reflecting a continuous or intermittent use, the perceived usefulness balanced with cumbersome measurements, routinization and personalization of the measurement process, and the way data are shared with the care team. Furthermore, 3 relationships were highlighted between the categories that reflect the necessary conditions for patient empowerment through the use of technology.

Conclusions
We discuss a theorization of the process of patient empowerment through the use of connected devices and call for further research to verify or amend it in the context of other technologies, illnesses, and care organizations.

Trial Registration
ClinicalTrials.gov NCT03304028; https://clinicaltrials.gov/ct2/show/results/NCT03304028
Effects of dietary protein and lipid levels on growth, feed utilization and meat quality of clown knifefish (Chitala chitala)
Authors: Tran Thi Thanh Hien , Lam My Lan , Tran Le Cam Tu 
Published: October 2022

Effects of dietary protein and lipid levels on growth, feed utilization and fillet quality of clown knifefish (Chitala chitala) were implemented to determine the protein and energy requirements of this species at 400 g stage. A 4 x 3 factorial design with four dietary protein levels (25%, 30%, 35% and 40%) and three dietary lipid levels (6, 9, and 12%) corresponded to 3 energies levels 18, 19 and 20 MJ/kg. Clown knifefish (407 ± 5.0 g) was stocked at a density of 10 fish/m2. The experiment was arranged in a completely randomized design in triplicate tanks for 8 weeks. There was a significant interaction effect (P<0.05) between protein and lipid levels on weight gain and specific growth rate with the fish growth being highest in the 35 CP-9% lipid treatment. The survival rate of fish was not affected (P>0.05) by dietary protein and lipid levels and ranged from 93.3 to 100%. The feed efficiency of fish was influenced by dietary protein or lipid content as well as the interaction between these two factors. Protein utilization efficiency increased as protein content increased, and diet contained t 35% protein and 9% lipid, enhanced chewiness and hardness of fish paste. These results showed that clown knifefish fed 32.8% dietary protein and 19 MJ energy with a P/E ratio of 18.6 had the optimal growth and the best quality of fish meat.