bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of radiologic scores for guiding individualized induction chemotherapy in T3N1M0 nasopharyngeal carcinoma
Authors: Yang Shan-Shan , Wu Yi-Shan , Pang Ya-Jun , Xiao Su-Ming , Zhang Bao-Yu , Liu Zhi-Qiao , Chen En-Ni , Zhang Xu , OuYang Pu-Yun , Xie Fang-Yun 
Published: January 2022

Abstract
Objectives
We aimed to develop and validate radiologic scores from [18F]FDG PET/CT and MRI to guide individualized induction chemotherapy (IC) for patients with T3N1M0 nasopharyngeal carcinoma (NPC).

Methods
A total of 542 T3N1M0 patients who underwent pretreatment [18F]FDG PET/CT and MRI were enrolled in the training cohort. A total of 174 patients underwent biopsy of one or more cervical lymph nodes. Failure-free survival (FFS) was the primary endpoint. The radiologic score, which was calculated according to the number of risk factors from the multivariate model, was used for risk stratification. The survival difference of patients undergoing concurrent chemoradiotherapy (CCRT) with or without IC was then compared in risk-stratified subgroups. Another cohort from our prospective clinical trial (N = 353, NCT03003182) was applied for validation.

Results
The sensitivity of [18F]FDG PET/CT was better than that of MRI (97.7% vs. 87.1%, p < 0.001) for diagnosing histologically proven metastatic cervical lymph nodes. Radiologic lymph node characteristics were independent risk factors for FFS (all p < 0.05). High-risk patients (n = 329) stratified by radiologic score benefited from IC (5-year FFS: IC + CCRT 83.5% vs. CCRT 70.5%; p = 0.0044), while low-risk patients (n = 213) did not. These results were verified again in the validation cohort.

Conclusions
T3N1M0 patients were accurately staged by both [18F]FDG PET/CT and MRI. The radiologic score can correctly identify high-risk patients who can gain additional survival benefit from IC and it can be used to guide individualized treatment of T3N1M0 NPC.

Key Points
• [18F]FDG PET/CT was more accurate than MRI in diagnosing histologically proven cervical lymph nodes.
• Radiologic lymph node characteristics were reliable independent risk factors for FFS in T3N1M0 nasopharyngeal carcinoma patients.
• High-risk patients identified by the radiologic score based on [18F]FDG PET/CT and MRI could benefit from the addition of induction chemotherapy.
Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy
Authors: León Xavier , García Jacinto , Pujol Albert , de Juan Julia , Vásquez Rosselin , Quer Miquel , Camacho Mercedes 
Published: January 2022

Abstract
Purpose
Proviral integration site for Moloney murine leukemia virus (PIMs) are proto-oncogenes encoding serine/threonine kinases that phosphorylate a variety of substrates involved in the regulation of cellular processes. Elevated expression of PIM-1 has been associated with poor prognosis in several types of cancer. There are no studies that have analyzed the response to radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) according to the expression of PIM-1. The aim of our study was to analyze the relationship between the transcriptional expression of PIM-1 and local response to radiotherapy in HNSCC patients.

Methods
We determined the transcriptional expression of PIM-1 in 135 HNSCC patients treated with radiotherapy, including patients treated with chemoradiotherapy (n = 65) and bioradiotherapy (n = 15).

Results
During the follow-up, 48 patients (35.6%) had a local recurrence of the tumor. Patients with local recurrence had a higher level of PIM-1 expression than those who achieved local control of the disease (P = 0.017). Five-year local recurrence-free survival for patients with a high expression of PIM-1 (n = 43) was 44.6% (95% CI 29.2–60.0%), and for patients with low expression (n = 92) it was 71.9% (95% CI 62.5–81.3%) (P = 0.007). According to the results of multivariate analysis, patients with a high PIM-1 expression had a 2.2-fold increased risk of local recurrence (95% CI 1.22–4.10, P = 0.009).

Conclusion
Patients with elevated transcriptional expression levels of PIM-1 had a significantly higher risk of local recurrence after radiotherapy.
Quartz-in-garnet barometry constraints on formation pressures of eclogites from the Franciscan Complex, California
Authors: Cisneros Miguel , Behr Whitney M. , Platt John P. , Anczkiewicz Robert 
Published: January 2022

AbstractDetermining pressure and temperature variations between high-pressure/low-temperature (HP–LT) eclogite blocks is crucial for constraining end-member exhumation models; however, it has historically been challenging to constrain eclogite pressures due to the high variance associated with this bulk-rock composition. In this work, we utilize quartz-in-garnet elastic barometry to constrain formation pressures of eclogites from the northern (Junction School, Ring Mountain, Jenner Beach) and southern Franciscan Complex (Santa Catalina Island). Multiple eclogite blocks from Jenner Beach are analyzed, and a single eclogite from the other localities. By comparing garnet growth conditions from within a single outcrop and between distinct outcrops, we evaluate the local and regional spatial distribution of P conditions recorded by eclogites. We compare the mean, median, and max pressures between different garnet zones and eclogites. Pressures sometimes exhibit systematic changes across garnet zones; however, some eclogites exhibit no systematic pressure variations across garnet zones. Pressures from northern Franciscan eclogites range from $$\sim $$
∼
1.4–1.8 GPa, at an estimated temperature of 500 $$^{\circ }$$

∘

C; pressures from the Catalina eclogite range from $$\sim $$
∼
1.2–1.5 GPa, at an estimated temperature of 650 $$^{\circ }$$

∘

C. Mean and maximum pressures of different eclogites from the northern Franciscan exhibit negligible differences (< 0.1 GPa). The results are inconsistent with models that propose exhumation of metamorphic blocks from different structural levels, and suggest that now exposed HP–LT eclogites from the northern Franciscan Complex may represent rocks that were coherently underplated, and exhumed from similar structural levels.
Contamination of personal protective equipment during COVID-19 autopsies
Authors: Brandner Johanna M. , Boor Peter , Borcherding Lukas , Edler Carolin , Gerber Sven , Heinemann Axel , Hilsenbeck Julia , Kasajima Atsuko , Lohner Larissa , Märkl Bruno , Pablik Jessica , Schröder Ann Sophie , Slotta-Huspenina Julia , Sommer Linna , Sperhake Jan-Peter , von Stillfried Saskia , Dintner Sebastian 
Published: January 2022

AbstractConfronted with an emerging infectious disease at the beginning of the COVID-19 pandemic, the medical community faced concerns regarding the safety of autopsies on those who died of the disease. This attitude has changed, and autopsies are now recognized as indispensable tools for understanding COVID-19, but the true risk of infection to autopsy staff is nevertheless still debated. To clarify the rate of SARS-CoV-2 contamination in personal protective equipment (PPE), swabs were taken at nine points in the PPE of one physician and one assistant after each of 11 full autopsies performed at four centers. Swabs were also obtained from three minimally invasive autopsies (MIAs) conducted at a fifth center. Lung/bronchus swabs of the deceased served as positive controls, and SARS-CoV-2 RNA was detected by real-time RT-PCR. In 9 of 11 full autopsies, PPE samples tested RNA positive through PCR, accounting for 41 of the 198 PPE samples taken (21%). The main contaminated items of the PPE were gloves (64% positive), aprons (50% positive), and the tops of shoes (36% positive) while the fronts of safety goggles, for example, were positive in only 4.5% of the samples, and all the face masks were negative. In MIAs, viral RNA was observed in one sample from a glove but not in other swabs. Infectious virus isolation in cell culture was performed on RNA-positive swabs from the full autopsies. Of all the RNA-positive PPE samples, 21% of the glove samples, taken in 3 of 11 full autopsies, tested positive for infectious virus. In conclusion, PPE was contaminated with viral RNA in 82% of autopsies. In 27% of autopsies, PPE was found to be contaminated even with infectious virus, representing a potential risk of infection to autopsy staff. Adequate PPE and hygiene measures, including appropriate waste deposition, are therefore essential to ensure a safe work environment.
Cytoarchitectonic parcellation and functional characterization of four new areas in the caudal parahippocampal cortex
Authors: Stenger Sophie , Bludau Sebastian , Mohlberg Hartmut , Amunts Katrin 
Published: January 2022

AbstractBrain areas at the parahippocampal gyrus of the temporal–occipital transition region are involved in different functions including processing visual–spatial information and episodic memory. Results of neuroimaging experiments have revealed a differentiated functional parcellation of this region, but its microstructural correlates are less well understood. Here we provide probability maps of four new cytoarchitectonic areas, Ph1, Ph2, Ph3 and CoS1 at the parahippocampal gyrus and collateral sulcus. Areas have been identified based on an observer-independent mapping of serial, cell-body stained histological sections of ten human postmortem brains. They have been registered to two standard reference spaces, and superimposed to capture intersubject variability. The comparison of the maps with functional imaging data illustrates the different involvement of the new areas in a variety of functions. Maps are available as part of Julich-Brain atlas and can be used as anatomical references for future studies to better understand relationships between structure and function of the caudal parahippocampal cortex.
Short-lived species move uphill faster under climate change
Authors: Couet Joséphine , Marjakangas Emma-Liina , Santangeli Andrea , Kålås John Atle , Lindström Åke , Lehikoinen Aleksi 
Published: January 2022

AbstractClimate change is pushing species ranges and abundances towards the poles and mountain tops. Although many studies have documented local altitudinal shifts, knowledge of general patterns at a large spatial scale, such as a whole mountain range, is scarce. From a conservation perspective, studying altitudinal shifts in wildlife is relevant because mountain regions often represent biodiversity hotspots and are among the most vulnerable ecosystems. Here, we examine whether altitudinal shifts in birds’ abundances have occurred in the Scandinavian mountains over 13 years, and assess whether such shifts are related to species’ traits. Using abundance data, we show a clear pattern of uphill shift in the mean altitude of bird abundance across the Scandinavian mountains, with an average speed of 0.9 m per year. Out of 76 species, 7 shifted significantly their abundance uphill. Altitudinal shift was strongly related to species’ longevity: short-lived species showed more pronounced uphill shifts in abundance than long-lived species. The observed abundance shifts suggest that uphill shifts are not only driven by a small number of individuals at the range boundaries, but the overall bird abundances are on the move. Overall, the results underscore the wide-ranging impact of climate change and the potential vulnerability of species with slow life histories, as they appear less able to timely respond to rapidly changing climatic conditions.
Virtual reality biofeedback interventions for treating anxiety
Authors: Kothgassner Oswald D. , Goreis Andreas , Bauda Ines , Ziegenaus Amelie , Glenk Lisa M. , Felnhofer Anna 
Published: January 2022

Summary
Background
Virtual reality (VR)-based biofeedback is a relatively new intervention and is increasingly being used for the treatment of anxiety disorders. This is the first research synthesis regarding effects and efficacy of this novel mode of treatment.

Method
We conducted a systematic review and meta-analysis of the VR biofeedback literature on treating anxiety symptoms. The MEDLINE/PubMed, Scopus and Web of Science databases were searched for eligible pre-post comparisons and randomized controlled trials (RCTs). We used self-reported anxiety, heart rate (HR), and heart rate variability (HRV) as primary outcome measures.

Results
A total of 7 studies with 191 participants reported VR biofeedback interventions. Of these studies 5 were RCTs, with 103 participants receiving VR biofeedback and 99 control participants (either 2D biofeedback or waiting list controls). We found that VR biofeedback significantly lowers self-reported anxiety (g = −0.28) and HR (g = −0.45), but not HRV. Furthermore, there were no significant differences in outcomes between VR biofeedback and 2D biofeedback but a significant reduction in HR in the VR biofeedback group compared with the waiting list (g = −0.52).

Conclusion
While the first findings are optimistic, more controlled studies with a wider variety of samples are needed to bring this field forward. Particularly, children and adolescents may profit from the combination of gamification elements, VR, and biofeedback.
Classification and pattern extraction of incidents: a deep learning-based approach
Authors: Sarkar Sobhan , Vinay Sammangi , Djeddi Chawki , Maiti J. 
Published: January 2022

AbstractClassifying or predicting occupational incidents using both structured and unstructured (text) data are an unexplored area of research. Unstructured texts, i.e., incident narratives are often unutilized or underutilized. Besides the explicit information, there exist a large amount of hidden information present in a dataset, which cannot be explored by the traditional machine learning (ML) algorithms. There is a scarcity of studies that reveal the use of deep neural networks (DNNs) in the domain of incident prediction, and its parameter optimization for achieving better prediction power. To address these issues, initially, key terms are extracted from the unstructured texts using LDA-based topic modeling. Then, these key terms are added with the predictor categories to form the feature vector, which is further processed for noise reduction and fed to the adaptive moment estimation (ADAM)-based DNN (i.e., ADNN) for classification, as ADAM is superior to GD, SGD, and RMSProp. To evaluate the effectiveness of our proposed method, a comparative study has been conducted using some state-of-the-arts on five benchmark datasets. Moreover, a case study of an integrated steel plant in India has been demonstrated for the validation of the proposed model. Experimental results reveal that ADNN produces superior performance than others in terms of accuracy. Therefore, the present study offers a robust methodological guide that enables us to handle the issues of unstructured data and hidden information for developing a predictive model.
Accuracy and agreement of national spine register data for 474 patients compared to corresponding electronic patient records
Authors: Alhaug Ole Kristian , Kaur Simran , Dolatowski Filip , Småstuen Milada Cvancarova , Solberg Tore K. , Lønne Greger 
Published: January 2022

Abstract
Purpose
Data quality is essential for all types of research, including health registers. However, data quality is rarely reported. We aimed to assess the accuracy of data in a national spine register (NORspine) and its agreement with corresponding data in electronic patient records (EPR).

Methods
We compared data in NORspine registry against data in (EPR) for 474 patients operated for spinal stenosis in 2015 and 2016 at four public hospitals, using EPR as the gold standard. We assessed accuracy using the proportion correctly classified (PCC) and sensitivity. Agreement was quantified using Kappa statistics or interaclass correlation coefficient (ICC).

Results
The mean age (SD) was 66 (11) years, and 54% were females. Compared to EPR, surgeon-reported perioperative complications displayed weak agreement (kappa (95% CI) = 0.51 (0.33–0.69)), PCC of 96%, and a sensitivity (95% CI) of 40% (23–58%). ASA classification had a moderate agreement (kappa (95%CI) = 0.73 (0.66–0.80)). Comorbidities were underreported in NORspine. Perioperative details had strong to excellent agreements (kappa (95% CI) ranging from 0.76 ( 0.68–0.84) to 0.98 (0.95–1.00)), PCCs between 93% and 99% and sensitivities (95% CI) between 92% (0.84–1.00%) and 99% (0.98–1.00%). Patient-reported variables (height, weight, smoking) had excellent agreements (kappa (95% CI) between 0.93 (0.89–0.97) and 0.99 (0.98–0.99)).

Conclusion
Compared to electronic patient records, NORspine displayed weak agreement for perioperative complications, moderate agreement for ASA classification, strong agreement for perioperative details, and excellent agreement for height, weight, and smoking. NORspine underreported perioperative complications and comorbidities when compared to EPRs. Patient-recorded data were more accurate and should be preferred when available.
Leaf wax composition and distribution of Tillandsia landbeckii reflects moisture gradient across the hyperarid Atacama Desert
Authors: Contreras Sergio , Landahur Manlio , García Karla , Latorre Claudio , Reyers Mark , Rethemeyer Janet , Jaeschke Andrea 
Published: January 2022

AbstractIn the hyperarid Atacama Desert, water availability plays a crucial role in allowing plant survival. Along with scant rainfall, marine advective fog frequently occurs along the coastal escarpment fueling isolated mono-specific patches of Tillandsia vegetation. In this study, we investigate the lipid biomarker composition of the bromeliad Tillandsia landbeckii (CAM plant) to assess structural adaptations at the molecular level as a response to extremely arid conditions. We analyzed long-chain n-alkanes and fatty acids in living specimens (n = 59) collected from the main Tillandsia dune ecosystems across a 350 km coastal transect. We found that the leaf wax composition was dominated by n-alkanes with concentrations (total average 160.8 ± 91.4 µg/g) up to three times higher than fatty acids (66.7 ± 40.7 µg/g), likely as an adaptation to the hyperarid environment. Significant differences were found in leaf wax distribution (Average Chain Length [ACL] and Carbon Preference Index [CPI]) in the northern zone relative to the central and southern zones. We found strong negative correlations between fatty acid CPI and n-alkane ACL with precipitation and surface evaporation pointing at fine-scale adaptations to low moisture availability along the coastal transect. Moreover, our data indicate that the predominance of n-alkanes is reflecting the function of the wax in preventing water loss from the leaves. The hyperarid conditions and good preservation potential of both n-alkanes and fatty acids make them ideal tracers to study late Holocene climate change in the Atacama Desert.
A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression
Authors: Kittel-Schneider Sarah , Davidova Petra , Kalok Miriam , Essel Corina , Ahmed Fadia Ben , Kingeter Yasmina , Matentzoglu Maria , Leutritz Anna Linda , Kersken Katharina , Koreny Carolin , Weber Heike , Kollert Leonie , McNeill Rhiannon V. , Reif Andreas , Bahlmann Franz , Trautmann-Villalba Patricia 
Published: January 2022

AbstractDepression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months postpartum (pp), we found that 3.7 to 15.7% of fathers screened positive for depression, and 9.6 to 24% of mothers, with at least a twofold increased prevalence in both parents using MADRS compared with EPDS. We also identified several psychosocial factors associated with perinatal depression in both parents. The data revealed a trend that lower BDNF levels correlated with maternal depressive symptoms at 3 months pp. In the fathers, no significant correlations between BDNF and perinatal depression were found. Pregnant women demonstrated lower BDNF methylation and BDNF protein expression compared with men; however, these were found to increase postpartum. Lastly, we identified correlations between depressive symptoms and psychosocial/neurobiological factors. The data suggest that BDNF may play a role in maternal perinatal depression, but not paternal.
The smallest space miners: principles of space biomining
Authors: Santomartino Rosa , Zea Luis , Cockell Charles S. 
Published: January 2022

AbstractAs we aim to expand human presence in space, we need to find viable approaches to achieve independence from terrestrial resources. Space biomining of the Moon, Mars and asteroids has been indicated as one of the promising approaches to achieve in-situ resource utilization by the main space agencies. Structural and expensive metals, essential mineral nutrients, water, oxygen and volatiles could be potentially extracted from extraterrestrial regolith and rocks using microbial-based biotechnologies. The use of bioleaching microorganisms could also be applied to space bioremediation, recycling of waste and to reinforce regenerative life support systems. However, the science around space biomining is still young. Relevant differences between terrestrial and extraterrestrial conditions exist, including the rock types and ores available for mining, and a direct application of established terrestrial biomining techniques may not be a possibility. It is, therefore, necessary to invest in terrestrial and space-based research of specific methods for space applications to learn the effects of space conditions on biomining and bioremediation, expand our knowledge on organotrophic and community-based bioleaching mechanisms, as well as on anaerobic biomining, and investigate the use of synthetic biology to overcome limitations posed by the space environments.
Numerical Modelling of Lithospheric Block-and-Fault Dynamics: What Did We Learn About Large Earthquake Occurrences and Their Frequency?
Authors: Ismail-Zadeh Alik , Soloviev Alexander 
Published: January 2022

AbstractDynamics of lithospheric plates resulting in localisation of tectonic stresses and their release in large earthquakes provides important information for seismic hazard assessments. Numerical modelling of the dynamics and earthquake simulations have been changing our view about occurrences of large earthquakes in a system of major regional faults and about the recurrence time of the earthquakes. Here, we overview quantitative models of tectonic stress generation and stress transfer, models of dynamic systems reproducing basic features of seismicity, and fault dynamics models. Then, we review the thirty-year efforts in the modelling of lithospheric block-and-fault dynamics, which allowed us to better understand how the blocks react to the plate motion, how stresses are localised and released in earthquakes, how rheological properties of fault zones exert influence on the earthquake dynamics, where large seismic events occur, and what is the recurrence time of these events. A few key factors influencing the earthquake sequences, clustering, and magnitude are identified including lithospheric plate driving forces, the geometry of fault zones, and their physical properties. We illustrate the effects of the key factors by analysing the block-and-fault dynamics models applied to several earthquake-prone regions, such as Carpathians, Caucasus, Tibet-Himalaya, and the Sunda arc, as well as to the global tectonic plate dynamics.