bluuebunny/crossref_metadata_2025_split huggingface dataset:
Condensed tannins act as anthelmintics by increasing the rigidity of the nematode cuticle
Authors: Greiffer Luise , Liebau Eva , Herrmann Fabian C. , Spiegler Verena 
Published: November 2022

AbstractTannins and tanniferous plant extracts have been discussed as sustainable means for helminth control in the past two decades in response to a dramatic increase of resistances towards standard anthelmintics. While their bioactivities have been broadly investigated in vitro and in vivo, less is known about their mode of action in nematodes, apart from their protein binding properties. In the current study we therefore investigated the impact of a phytochemically well characterized plant extract from Combretum mucronatum, known to contain procyanidins as the active compounds, on the model organism Caenorhabditis elegans. By different microscopic techniques, the cuticle was identified as the main binding site for tannins, whereas underlying tissues did not seem to be affected. In addition to disruptions of the cuticle structure, molting defects occurred at all larval stages. Finally, an increased rigidity of the nematodes’ cuticle due to binding of tannins was confirmed by force spectroscopic measurements. This could be a key finding to explain several anthelmintic activities reported for tannins, especially impairment of molting or exsheathment as well as locomotion.
Cannabidiol affects breast meat volatile compounds in chickens subjected to different infection models
Authors: Konieczka Paweł , Wojtasik-Kalinowska Iwona , Poltorak Andrzej , Kinsner Misza , Szkopek Dominika , Fotschki Bartosz , Juśkiewicz Jerzy , Banach Joanna , Michalczuk Monika 
Published: November 2022

AbstractNo study has demonstrated the use of dietary Cannabis-derived cannabidiol (CBD) to alter the stress response in chickens or examined its effects on meat volatile compounds (VOCs). Here, we subjected chickens to dysbiosis via C. perfringens infection or Escherichia coli lipopolysaccharide (LPS) treatment and investigated the potential link between meat VOCs and cecal bacterial activity and the ameliorative effect of CBD. The cecal bacterial production of short-chain fatty acids (SCFAs) was closely correlated with meat VOCs. CBD supplementation reduced the formation of breast meat spoilage VOCs, including alcohols, trimethylamine and pentanoic acid, in the challenged birds, partly by decreasing cecal putrefactive SCFA production. Meat VOC/cecal SCFA relationships differed according to the challenge, and CBD attenuated the effects of C. perfringens infection better than the effects of LPS challenge on meat VOCs. These findings provide new insights into the interactions among bioactive agent supplementation, gut microbiota activity and meat properties in birds.
Anti-biofilm activity of caffeine against uropathogenic E. coli is mediated by curli biogenesis
Authors: Rathi Bhawna , Gupta Surbhi , Kumar Parveen , Kesarwani Veerbhan , Dhanda Rakesh Singh , Kushwaha Sandeep Kumar , Yadav Manisha 
Published: November 2022

AbstractBiofilms are assemblages of sessile microorganisms that form an extracellular matrix around themselves and mediate attachment to surfaces. The major component of the extracellular matrix of UropathogenicE. coliand other Enterobacteriaceae are curli fibers, making biofilms robust and resistant to antimicrobials. It is therefore imperative to screen antibiofilm compounds that can impair biofilm formation. In the present study, we investigated the curli-dependent antibiofilm activity of caffeine against UPEC strain CFT073 and commensal strainE. coliK-12MG1655.Caffeine significantly reduced the biofilm formation of both UPEC andE. coliK-12 by 86.58% and 91.80% respectively at 48 mM caffeine as determined by Crystal Violet assay. These results were further confirmed by fluorescence microscopy and Scanning Electron Microscope (SEM). Caffeine significantly reduced the cytotoxicity and survivability of UPEC. Molecular docking analysis revealed a strong interaction between caffeine and curli regulator protein (Csg D) ofE. coli. The qRT-PCR data also showed significant downregulation in the expression of CsgBA and the CsgDEFG operon at both 24 mM and 48 mM caffeine. The findings revealed that caffeine could inhibitE. colibiofilm formation by regulating curli assembly and thus may be used as an alternative therapeutic strategy for the treatment of chronicE. colibiofilm-related infections.
A novel puncture approach via point “O” for percutaneous kyphoplasty in patients with L4 or L5 osteoporotic vertebral compression fracture
Authors: Huang Jiahu , Yang Jin , Chen Lanjing , Xu Yinzhi , Wang Song 
Published: November 2022

AbstractThis study introduced a novel point “O” puncture approach for percutaneous kyphoplasty (PKP) in patients with L4 or L5 osteoporotic vertebral compression fracture (OVCF) and evaluated its clinical and radiographic outcomes. Between September 2019 and December 2020, we compared the clinical and radiographic outcomes in 31 cases (36 vertebrae) using the “O” entry point PKP intervention (O-PKP) and 31 cases (37 vertebrae) using transverse the process-pedicle approach PKP intervention (T-PKP). No serious postoperative complications were observed in any of the participants. Only two T-PKP patients experienced intervertebral disc space leakage. Compared with the T-PKP patients, the O-PKP patients showed shorter operative time and fluoroscopy times (P < 0.05), comparable blood loss and cement volume (P > 0.05), improved VAS and ODI scores at the final follow-up (P < 0.05), better increases in the vertebral compression ratio (P < 0.05), comparable Cobb angle (P > 0.05), comparable anteroposterior bone cement distribution, enhanced bilateral bone cement distribution (P < 0.05), and larger sagittal and transverse angles (P < 0.05). Herein, O-PKP was indicated for patients with L4 or L5 OVCF. This puncture approach showed significant advantages over T-PKP not only in terms of pain relief, surgery and fluoroscopy times but also in the puncture angle, vertebral reconstruction, and symmetrical cement distribution.
Association of urinary prostaglandin E2 metabolite and mortality among adults
Authors: Wen Wanqing , Yang Gong , Cai Qiuyin , Shu Xiao-Ou , Zheng Wei 
Published: November 2022

AbstractProstaglandins play a critical role in inflammatory response. To investigate the association of urinary PGE-M, a stable end-product of prostaglandin E2 (PGE2) with overall and cause-specific mortality and examine potential effect modifiers, we obtained urinary PGE-M levels of 2927 non-cancerous adults from our previous case-control studies nested in the Shanghai Women’s Health Study and Shanghai Men’s Health Study, two cohort studies conducted in Shanghai, China. Mortality data and modifiable factors associated with urinary PGE-M were obtained from the parent cohort studies. Using linear regression models, we found that high urinary PGE-M levels were significantly associated with low education, heaving smoking, old age at urine collection, and abdominal obesity. Using Cox proportional hazards models, we found that increase (per standard deviation) of urinary PGE-M levels were significantly associated with overall mortality (adjusted hazard ratio = 1.19, 95% confidence interval: 1.07, 1.33) and particularly deaths from cardiometabolic diseases (adjusted hazard ratio = 1.27, 95% confidence interval: 1.11, 1.44). The increased death risks persisted across different time intervals during the follow-up and were stronger among participants who were younger than 60 (P = 0.0014 for all- cause mortality and P = 0.007 for deaths from cardiometabolic diseases) at urine collection or perhaps among those who had higher education.
Unit commitment with frequency‐arresting adequacy constraint: Modelling and pricing aspects
Authors: Davari Nejad Ehsan , Hesamzadeh Mohammad Reza , Orostica Hector Chavez 
Published: November 2022

AbstractFrequency‐arresting (FA) adequacy has received an increasing attention in operation of power systems with intermittent, electronically connected wind and sfolar generation. Presence of high penetration of renewable energy leads to reduced amount of inertia in the power system and the need for more sustainable market design. This paper addresses the FA adequacy by integrating Nadir and rate of change of frequency constraints in unit commitment formulation. Here, a mixed‐integer linear program (MILP) is proposed for addressing the FA adequacy. The proposed MILP model of FA adequacy is non‐convex and accordingly, FA adequacy pricing requires non‐convex pricing techniques. The explicit and implicit uplift payment techniques are proposed and implemented for FA adequacy pricing using the authors' proposed MILP model. The primal–dual formulation is employed for implicit uplift technique. The proposed MILP model of FA adequacy along with its pricing techniques is carefully studied through an illustrative example system. For further discussions, the Nordic 44‐node test network is studied.
First report of complete enteroscopy from ileocecal valve to pylorus by retrograde
motorized power spiral endoscopy
Authors: Steinbrück Ingo , Allgaier Hans-Peter 
Published: November 2022

AbstractThe development of capsule endoscopy and device-assisted enteroscopy (DAE) revolutionized
minimally invasive examination and treatment of small bowel diseases. Limitations of DAE are a
great time expenditure and low rates of complete enteroscopy. Recently motorized spiral
enteroscopy (MSE) was introduced with shorter procedure times and concurrently greater
insertion depths. MSE is also the first device that opens up the possibility to achieve
complete enteroscopy in a relevant number of cases by the unidirectional, peroral
approach.To our knowledge we present the first published case of complete enteroscopy by retrograde
MSE in a 35-year-old female without prior abdominal surgery with direct endoscopic
visualization of the pyloric ring. The patient suffered from colonic polyposis syndrome. For
the exploration of both colorectum and the small bowel we performed retrograde MSE under
propofol sedation. After 60 minutes of advancement, we achieved complete enteroscopy by
retrograde identification of the pyloric ring. The procedure could be finished after
withdrawal of the endoscope and cold snare polypectomy of 3 small colonic adenomas without any
adverse events. Total procedure time was 82 minutes. The patient was discharged one day after
the procedure without complaints.It has been proven already that great insertion depths are achievable by retrograde MSE,
but this case shows for the first time that even a complete enteroscopy is possible. In
conclusion, primary retrograde MSE with no need of tracheal intubation might be a key to more
effective, time-preserving, and cost-effective concepts of small-bowel endoscopy in the
future.
Recent Advances in Chiral Aldehyde Catalysis for Asymmetric Functionalization of Amines
Authors: Wen Wei , Guo Qi-Xiang 
Published: November 2022

AbstractAsymmetric functionalization of amines and their derivatives is of great significance in synthetic chemistry and is widely used in the preparation of natural products and pharmaceuticals. In recent years, chiral aldehyde catalysis has emerged as a well-established and recognized tool, providing excellent catalytic activation and stereoselective control in asymmetric reactions of N-unprotected amino acid esters and amino acid ester analogues. In this short review, recent advances in enantioselective aldehyde catalysis, including chiral aldehydes as organocatalysts and co-catalysis combined with transition metals, will be summarized. Lastly, continued development of enantioselective aldehyde catalysis is prospected in the future.1	Introduction2	Chiral Aldehyde Catalysis for Tethering Strategy3	Chiral Aldehyde Catalysis for Imine Activation4	Chiral Aldehyde/Transition Metal Cooperative Catalysis5	Conclusion
Association between Interleukin-6 rs1800795 Polymorphism and Serum Interleukin-6 Levels and Full-Term Neonatal Sepsis
Authors: Zhao Xiao-Fen , Yang Mi-feng , Wu Yu-qin , Zhao Peng-na , Zhu Shuang-Yan , Xiong Fei , Fan Mao , Li Yang-Fang 
Published: November 2022

Abstract
Objective Cytokines are involved in the pathogenesis of sepsis. Association between IL-6 rs1800795 G/C polymorphism and the risks of sepsis is controversial. The aim of this study was to investigate the association of IL-6 rs1800795 G/C gene polymorphism with full-term neonatal sepsis and to determine its effect on the serum IL6 levels in these infants by a prospective study.
Methods The study included 200 full-term neonates from January 2019 to December 2020: 100 with sepsis (sepsis group), 47 with culture proven sepsis, and 53 with clinical sepsis, and 100 without infection (control group). The concentrations of IL-6 in serum were determined using enzyme-linked immunosorbent assay (ELISA). The polymorphisms of IL-6 rs1800795 G/C were analyzed to compare the genotypic and allelic frequencies in the groups by using the first-generation sequencing (Sanger sequencing). The association was studied between IL-6 rs1800795 G/C polymorphisms and serum IL-6 levels, and neonatal sepsis. The relationships between IL-6 rs1800795G/C polymorphisms and sepsis and serum IL-6 levels were separately analyzed by logistic regression and analysis of variance.
Results There were no significant differences in genotypic frequencies and allelic frequencies of IL-6 rs1800795(G/C) in the groups (p >0.05). There were no relations between IL-6 rs1800795G/C polymorphisms and sepsis and serum IL-6 levels by statistical analysis (p >0.05).
Conclusion IL-6rs1800795G/C may not be genetic risk factors for full-term neonates; There was no association between serum IL-6 levels and IL-6 rs1800795G/C polymorphisms.
Prevention of Health Care–Associated Measles Transmission in a Pediatric Clinic
Authors: Kaman Ayşe , Oğuz Melahat Melek 
Published: November 2022

Abstract
Objective Preventive measures in the setting of a suspected measles case in a hospital setting are important to stop the secondary spread. In this report, we evaluated the prevention attempts after two suspected cases of measles were reported in a pediatric clinic.
Methods We evaluated prevention interventions including isolation, intravenous immunoglobulin, or measles–mumps–rubella (MMR) vaccine after two patients were diagnosed with maculopapular rash compatible with measles in the pediatric clinic.
Results There were 50 patients (29 were outpatients, 21 were inpatients), 19 health care personnel (HCP), and 50 caregivers who were in contact with index cases. All of the HCP and 40 of the caregivers were immune to measles. Additional dose of MMR vaccine was recommended to five of the outpatients by phone. A total of 12 patients who were being followed up as inpatients (8 patients aged 6–12 months, 4 patients aged ≥ 12 months) were vaccinated with one dose of MMR vaccine. Only a 12-year-old male patient was admitted due to complaints suggesting measles after 14 days from discharge. It was learned that he had received a single dose of vaccine before so he was recommended an additional dose of MMR vaccine by the phone, but he did not go to the health institution on the day of the call.
Conclusion Postexposure prophylaxis is effective to prevent measles transmission. Although young infants have the highest risk for transmission of measles in a health care–associated outbreak, adolescents and older children who are single vaccinated also have high risk for clinical measles.
Post collision analyzer to study charge-exchange processes in ion-molecule collisions
Authors: Srivastav Sumit , Bapat Bhas 
Published: November 2022

We have designed an electrostatic charge state analyzer for ion beams having energies in the range of 5–20 keV/q. It is primarily built to investigate the different ionization processes involved in the slow (v &lt; 1 a.u.) impact of highly charged ions on molecules. The analyzer is a cylindrical deflector analyzer (CDA) based on a pair of concentric cylindrical sectors of radii 110.2 and 95 mm, subtending an angle of 127° at its center. Additionally, an Einzel lens and a quadrupole deflector are deployed to focus and steer the ion beam. The compact design of the analyzer permits easy integration with an ion momentum spectrometer used for studying the fragmentation of the target molecules. The characterization of the CDA including its calibration and its transmission function is carried out using an ion beam delivered from an electron beam ion source. To check the performance of the setup, we have carried out experiments comprising the impact of Ar16+ projectiles on CO2 target molecules at an energy of 18 keV/q. With the help of the CDA, different charge exchange ionization processes, such as single capture, double capture, and triple capture of electrons by the projectile ion have been separated efficiently. The possibility of a modification in the geometry of CDA is discussed to further improve its performance.
Microfluidics guided by deep learning for cancer immunotherapy screening
Authors: Ao Zheng , Cai Hongwei , Wu Zhuhao , Hu Liya , Nunez Asael , Zhou Zhuolong , Liu Hongcheng , Bondesson Maria , Lu Xiongbin , Lu Xin , Dao Ming , Guo Feng 
Published: November 2022

Immunocyte infiltration and cytotoxicity play critical roles in both inflammation and immunotherapy. However, current cancer immunotherapy screening methods overlook the capacity of the T cells to penetrate the tumor stroma, thereby significantly limiting the development of effective treatments for solid tumors. Here, we present an automated high-throughput microfluidic platform for simultaneous tracking of the dynamics of T cell infiltration and cytotoxicity within the 3D tumor cultures with a tunable stromal makeup. By recourse to a clinical tumor-infiltrating lymphocyte (TIL) score analyzer, which is based on a clinical data-driven deep learning method, our platform can evaluate the efficacy of each treatment based on the scoring of T cell infiltration patterns. By screening a drug library using this technology, we identified an epigenetic drug (lysine-specific histone demethylase 1 inhibitor, LSD1i) that effectively promoted T cell tumor infiltration and enhanced treatment efficacy in combination with an immune checkpoint inhibitor (anti-PD1) in vivo. We demonstrated an automated system and strategy for screening immunocyte-solid tumor interactions, enabling the discovery of immuno- and combination therapies.
A dynamic topography for visualizing time and space in fictional literary texts
Authors: Richardson Andrew , Hay Duncan 
Published: November 2022

Abstract
This paper presents research on creating interactive prototypes for visualizing temporal spatial relationships in
fictional literary texts. Developed within the context of the Chronotopic Cartographies project, a practice-led inquiry yielded
dynamic visualizations from literary texts, the research explores the development and application of interactive three-dimensional
environments illustrating the ‘chronotopic’, time-space relationships across a series of fictional literary texts. Expert feedback
highlights the potential of the interaction model as a useful visual paradigm for supporting methods of reflective inquiry
hypothesis making. The work also represents a potential model for creating interactive temporal visualizations which support
hypothesis making across a broader sphere of the humanities.
Ad hoc concepts and the relevance heuristics
Authors: Leclercq Benoît 
Published: November 2022

AbstractThe idea that interpreting a lexeme typically involves a context-dependent process of meaning construction has in recent years become common ground in linguistic theory. This view is very explicit in relevance theory (Sperber and Wilson 1995), which posits that speakers systematically infer ad hoc concepts (Carston 2002). Such an approach raises theoretical issues, though. First, it directly poses a challenge for the exact nature of (and difference between) concepts and ad hoc concepts (Carston 2002, 249). In addition, as Wilson (2011,2016) and Carston (2013,2016) point out, this view also uncovers the following paradox: if speakers are assumed to follow a path of least effort (relevance heuristics), why should they so systematically infer ad hoc concepts rather than test the encoded concept first? The aim of this paper is to reflect on this theoretical puzzle. It will first be argued that the hypotheses formulated both by Wilson and by Carston seem rather post hoc and fail to fully resolve the apparent paradox. Attention will then be given to the assumed nature of (ad hoc) concepts to show that the problem can be resolved when an alternative (non-atomic) view of concepts in terms of meaning potential is adopted.
Relevance of dissociative molecular states for resonant two-center photoionization of heteroatomic dimers
Authors: Grüll F , Voitkiv A B , Müller C 
Published: November 2022

AbstractPhotoionization of a weakly bound van-der-Waals dimer, composed of two atomic speciesAandB, is studied theoretically. AtomAcan be ionized either directly or via an indirect two-center channel, where atomBis first resonantly photoexcited and, afterwards, transfers the excitation energy via long-range electron–electron correlations radiationlessly to atomA, causing its ionization. By taking the vibrational nuclear motion of the dimer during the process into account, we analyze the contributions to the photoionization cross section from bound and dissociative molecular states in the finalA+–Bsystem. For the specific example of a LiHe dimer we show (a) that substantial contributions to both ionization mechanisms result from dissociative Li++He states and (b) that the two-center pathway strongly dominates over the direct photoionization channel for photon energies close to one of the molecular LiHe resonances.
Angular displacement sensor for gear position detection based on the tunneling magnetoresistance effect
Authors: Wang Yangyang , Qin Yi , Chen Xihou , Peng Donglin , Tang Qifu , Zhang Tianheng 
Published: November 2022

Abstract
In the fields of robotics, machine tools and spacecraft, measurement of the gear angular position lays the foundation for closed-loop positional feedback. In this article, an angular displacement sensor based on the tunneling magnetoresistance (TMR) effect is proposed for the precise measurement of angular displacement. The developed sensor mainly consists of a TMR element, a signal conditioning circuit, a permanent magnet and some necessary assembly components. The TMR element is composed of eight magnetic tunnel junctions, which are arranged according to the dual-full bridge structure with a spatial electric angle difference of π/2. Signals containing time information and space information are obtained after the sinusoidal and cosine voltages signals are respectively connected in two bridges. The signals are processed by a signal conditioning circuit, and then the angular displacement is measured by counting the clock pulses. The structure, working principles and signal conditioning method of the sensor are presented in detail. Moreover, a sensor prototype and a conditioning circuit are designed for actual experiments, according to the measured gear with a modulus of 1 and tooth number of 240. The prototype sensor has a theoretical resolution of 0.00001°. The experimental results show that the prototype sensor has a working stability of ±0.00023° within 1 h, and its measurement accuracy is −0.0008611° to 0.001361° in the measurement range from 0° to 360°. Therefore, the proposed sensor can be applied to the highly precise measurement of angular displacement.