bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis
Authors: Ma Hongbo , Liu Shengming , Li Shanrui , Xia Yong 
Published: June 2022

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown origin that usually results in death from secondary respiratory failure within 2–5 years of diagnosis. Recent studies have identified key roles of cytokine and growth factor pathways in the pathogenesis of IPF. Although there have been numerous clinical trials of drugs investigating their efficacy in the treatment of IPF, only Pirfenidone and Nintedanib have been approved by the FDA. However, they have some major limitations, such as insufficient efficacy, undesired side effects and poor pharmacokinetic properties. To give more insights into the discovery of potential targets for the treatment of IPF, this review provides an overview of cytokines, growth factors and their signaling pathways in IPF, which have important implications for fully exploiting the therapeutic potential of targeting cytokine and growth factor pathways. Advances in the field of cytokine and growth factor pathways will help slow disease progression, prolong life, and improve the quality of life for IPF patients in the future.
Hemoglobin Mass, Blood Volume and VO2max of Trained and Untrained Children and Adolescents Living at Different Altitudes
Authors: Mancera-Soto Erica Mabel , Ramos-Caballero Diana Marcela , Rojas J. Joel A. , Duque Lohover , Chaves-Gomez Sandra , Cristancho-Mejía Edgar , Schmidt Walter Franz-Joachim 
Published: June 2022

Introduction: To a considerable extent, the magnitude of blood volume (BV) and hemoglobin mass (Hbmass) contribute to the maximum O2-uptake (VO2max), especially in endurance-trained athletes. However, the development of Hbmass and BV and their relationships with VO2max during childhood are unknown. The aim of the present cross-sectional study was to investigate Hbmass and BV and their relationships with VO2max in children and adolescents. In addition, the possible influence of endurance training and chronic hypoxia was evaluated.Methods: A total of 475 differently trained children and adolescents (girls n = 217, boys n = 258; untrained n = 171, endurance trained n = 304) living at two different altitudes (∼1,000 m, n = 204, ∼2,600 m, n = 271) and 9–18 years old participated in the study. The stage of puberty was determined according to Tanner; Hbmass and BV were determined by CO rebreathing; and VO2max was determined by cycle ergometry and for runners on the treadmill.Results: Before puberty, there was no association between training status and Hbmass or BV. During and after puberty, we found 7–10% higher values in the trained groups. Living at a moderate altitude had a uniformly positive effect of ∼7% on Hbmass in all groups and no effect on BV. The VO2max before, during and after puberty was strongly associated with training (pre/early puberty: boys +27%, girls +26%; mid puberty: +42% and +45%; late puberty: +43% and +47%) but not with altitude. The associated effects of training in the pre/early pubertal groups were independent of Hbmass and BV, while in the mid- and late pubertal groups, 25% of the training effect could be attributed to the elevated Hbmass.Conclusions: The associated effects of training on Hbmass and BV, resulting in increased VO2max, can only be observed after the onset of puberty.
Effects of Different Levels of Garlic Straw Powder on Growth Performance, Meat Quality, Antioxidant and Intestinal Mucosal Morphology of Yellow-Feathered Broilers
Authors: Liao Shuang , Liao Liping , Huang Peng , Wang Yanzhou , Zhu Siyuan , Wang Xin , Lv Tuo , Li Yinghui , Fan Zhiyong , Liu Touming , Lin Qian 
Published: June 2022

The full utilization of garlic straw can partially alleviate shortage of feedstuff and waste of resources. The purpose of this study was to investigate the effects of garlic straw as an unconventional feed on yellow-feathered broilers. 360 28-day-old yellow-feathered broilers were randomly divided into 4 groups with 6 replicates (cage) per group, 15 per cage. The 4 groups were as follows: control group (basal diet) and experimental group I (basal diet supplemented with 3% garlic straw powder), II (basal diet supplemented with 6% garlic straw powder) and III (basal diet supplemented with 9% garlic straw powder). There was no significant difference in the initial body weight of the broilers among groups (p &gt; 0.05). The test period was 28 days in total. The experiment results showed that there were no significant difference in the average final weight, ADG, ADFI and F/G among groups (p &gt; 0.05). On the one hand, for the breast muscle, the drip loss of experimental group I, II and III were reduced by 17.24% (p &lt;0.05), 20.11% (p &lt;0.05) and 20.50% (p &lt;0.05), respectively, compared with the control group; the redness a* of the experimental groups had a trend of improvement (0.05 &lt;p &lt; 0.1). On the other hand, compared with the control group, the redness a* of the experimental group II increased significantly by 23.18% for the leg muscles (p &lt; 0.05). Furthermore, compared with the control group, GSH-Px of the experimental group III significantly increased by 21.38% (p &lt; 0.05), and SOD of the experimental group I significantly increased by 21.85% (p &lt; 0.05). Finally, there were no significant differences in the intestinal villus height, crypt depth, V/C and intestinal wall thickness among four groups (p &gt;0.05). In conclusion, dietary supplementation of different levels of garlic straw powder can improve meat quality and antioxidant capacity of yellow-feathered broilers without affecting growth performance and intestinal mucosal morphology.
Aesthetic Preference for Negatively-Valenced Artworks Remains Stable in Pathological Aging: A Comparison Between Cognitively Impaired Patients With Alzheimer's Disease and Healthy Controls
Authors: Kliem Elisabeth , Forster Michael , Leder Helmut 
Published: June 2022

BackgroundDespite severe cognitive dysfunction in Alzheimer's disease (AD), aesthetic preferences in AD patients seem to retain some stability over time, similarly to healthy controls. However, the underlying mechanisms of aesthetic preference stability in AD remain unclear. We therefore aimed to study the role of emotional valence of stimuli for stability of aesthetic preferences in patients with AD compared to cognitively unimpaired elderly adults.MethodsFifteen AD patients (Mini-Mental State Examination (MMSE) score 12–26) without visual impairment and/or psychiatric disorder, as well as 15 healthy controls without cognitive impairment (MMSE ≥ 27) matched in age, sex, art interest and highest level of education were included in this study. All participants were asked to rank-order eight artworks per stimulus category (positive, negative, neutral in emotional valence) according to their preference twice with a 2-week span in-between. Based on these two rankings a preference change score was calculated. In order to assess explicit recognition memory of the artworks in the second testing session, four artworks of each stimulus category used in the preference ranking task were presented together with a content-matched distractor artwork painted by the same artist. Participants had to indicate which of the stimuli they had seen 2 weeks previously.ResultsAD patients [MMSE (M) = 18.9 ± 3.6; Age (M) = 85.4 ± 6.9; 33.3% male] had no explicit recognition memory of the artworks (recognition at chance level), whereas healthy controls [MMSE (M) = 27.7 ± 1.4; Age (M) = 84.3 ± 6.7; 33.3% male] correctly recognized 85% of stimuli after 2 weeks. AD patients had equally stable preferences compared to the control group for negative artworks, but less stable preferences for positive and neutral images (Bonferroni-corrected significance levels; p &lt; 0.017).ConclusionEven in cognitively impaired AD patients, aesthetic preference for negatively-valenced artworks remains relatively stable. Our study provides novel evidence that AD patients may have a somewhat preserved implicit valence system for negative compared to neutral or positive visual information, especially in the domain of aesthetics. However, more studies need to further uncover the details of the underlying neurocognitive mechanisms of preference stability in pathological aging.
Different Impacts of COVID-19 on Quality of Therapy, Psychological Condition, and Work Life Among Occupational Therapists in Physical and Mental Health Fields
Authors: Sawamura Daisuke , Ito Ayahito , Miyaguchi Hideki , Nakamura Haruki , Ishioka Toshiyuki 
Published: June 2022

BackgroundThe negative impacts of the coronavirus disease 2019 (COVID-19) pandemic have worsened the quality of therapy, psychological condition, and work life of second-line healthcare workers and occupational therapists (OTs). However, no study has investigated whether the impact of COVID-19 varies among OTs working in different fields. This study aimed to investigate the differences on the impact of COVID-19 between OTs in the physical and mental health fields.MethodsA cross-sectional online survey was conducted in Japan between January 20 and January 25, 2021. A total of 4,418 registered OTs who were members of the Japanese Association of Occupational Therapists volunteered for this study. After screening using the exclusion criteria, 1,383 participants were classified into two groups based on their field (mental health and physical health), and their quality of therapy, psychological condition, and work life were analyzed.ResultsOTs in the mental health field showed a greater decrease in therapy quality and increase in workload and a lower rate of decrease in working hours than those in the physical health field. In the multinomial logistic regression analysis, decreased and increased therapy quality and decreased therapy quality were significantly associated with depression in the physical health field, and decreased therapy quality was associated with insomnia in the mental health field. Furthermore, insomnia and anxiety were commonly associated with increased workload and working hours, respectively, in both fields, whereas anxiety and depression were associated with increased workload only in the physical health field.ConclusionsThese results demonstrate that COVID-19 differently impacted quality of treatment, workload, work time, and psychological condition in the physical and mental health fields; moreover, the relationships among these are different in these two fields. These results highlight the importance of investigating the field-specific negative impacts of COVID-19 on OTs and may provide helpful information for devising tailored and effective prevention and intervention strategies to address these challenges.
“Exercise Is My Medicine”: A Qualitative Study Exploring the Experiences of Non-admitted Patients Receiving Physical Activity Promotion From Hospital Surgeons
Authors: Barrett Stephen , Begg Stephen , O'Halloran Paul , Rodda Kane , Barrett Gabrielle , Kingsley Michael 
Published: June 2022

BackgroundHospital clinicians are increasingly encouraged to use outpatient consultations as an avenue to deliver opportunistic health promotion. There is a dearth of evidence regarding the acceptance of health promotion initiatives from hospital patients themselves.MethodsWe explored the experiences of non-admitted patients who, during a routine consultation with a hospital surgeon received a recommendation to increase physical activity (PA) and a recommendation to engage in a PA telephone coaching program. Twenty-two semi-structured interviews were conducted with individuals who had received the recommendation and proceeded to enroll in a telephone coaching intervention to identify factors that influenced behavior change. Data were analyzed thematically.ResultsParticipants' age ranged between 42 and 66 years, with the average age being 54 years. Of the participants, 15 (68%) were women and 7 (32%) were men. Three major themes were identified: (1) the hospital visit represented an opportunity for behavior change that is not to be missed; (2) surgeons were influential in promoting PA change contemplation; and (3) patients welcomed a communication style that promoted autonomy.ConclusionsAlmost all patients considered receiving the recommendation to engage with the telephone coaching as acceptable and helpful toward PA change. Although working in time-restricted consultations, surgeons delivered the recommendation in a patient-centered, autonomy-supportive way, which influenced behavior change. Hospitals should explore avenues to integrate health promotion into routine care, confident of the acceptability and appropriateness of health promotion practice to hospital patients.
Analisis Status Kesuburan Tanah Pada Kebun Petani Desa Ladogahar Kecamatan Nita Kabupaten Sikka
Authors: Trisnawati Agustina 
Published: June 2022

Pendahuluan: Kesuburan tanah merupakan salah satu penentu kestabilan dan peningkatan produksi pertanian. Tanah dapat dikatakan subur jika tanaman yang ditanam diatasnya dapat tumbuh dan berkembang dengan baik dan produksinya tinggi sepanjang tahun. Penilaian status kesuburan tanah dapat dilakukan melalui pendekatan uji tanah menggunakan alat uji perangkat tanah kering (PUTK) yang dibuat oleh Balai Penelitian Tanah Balai Besar Penelitian Dan Pengembangan Sumberdaya Lahan Pertanian Departemen Pertanian Tujuan Tujuan Penelitian ini adalah untuk mengetahui status kesuburan tanah pada kebun petani di Desa Ladogahar Kecamatan Nita Kabupaten Sikka. Penelitian ini telah dilaksanakan di kebun petani Desa Ladogahar Kecamatan Nita Kabupaten Sikka pada bulan Oktober sampai Desember 2021. Metode Metode yang digunakan dalam peneltian ini adalah metode zig-zag Hasil Hasil penelitian menunjukan bahwa analisis status kesuburan tanah pada kebun petani Desa Ladogahar Kecamatan Nita Kabupaten Sikka, kandungan pH tanah sampel TS1 tergolong netral (pH 6-7) dan sampel TS2, TS3, TS4 tergolong agak masam (pH 5-6), sedangkan P- tanah tergolong tinggi pada sampel TS1,TS2, TS3, TS4 dan kandungan K- tanah tergolong sedang pada sampel TS1, TS4 hingga rendah pada sampel TS2, TS3 dan kandungan C-organik tanah tergolong rendah pada sampel TS1, TS2, TS3 dan TS4. Rendahnya C-organik tanah karena kondisi lahan pertanian yang terletak pada dataran tinggi dengan pengolahan tanah yang kurang baik menyebabkan humus berkurang akibat erosi, kurangnya vegetasi pada tanah akibat sering diolah untuk dilakukan penanaman dan diangkutnya sisa-sisa panen keluar areal pertanaman Kesimpulan sifat fisika dan kimia tanah pada kebun petani Desa Ladogahar Kecamatan Nita secara umum sedang. Hal ini disebabkan karena unsur hara pada kebun tersebut telah digunakan untuk budidaya tanaman holtikultura dalam pertumbuhan dan produksi
Implementasi Marketing Communication dalam Meningkatkan Customer Value: Case Study Pada Butik Alisha Fancy Shop Kota Bandung
Authors: Hikmawati Nina Kurnia , Munandar Dadang 
Published: June 2022

Abstract - Marketing communication that is known today is one of the strategies that need to be considered by companies because one or more process stages cannot be ignored from the company's business processes. It was further stated that no matter how good the marketing strategy plan is if it is not supported by good communication through marketing communications, the results will not be optimal. Examining the phenomenon of marketing communication, this research focuses on examining the implementation of marketing communications. The research focused on a case study of the company, namely Alisha Fanshy Shop Boutique, which examined the marketing communications carried out while the sampling technique was carried out with non-probability. Because this research is included in quantitative research, the data analysis is carried out using a regression analysis approach. The results showed that the part of marketing communication at Alisha Fancy Shop Boutique was very good, customer value at Alisha Fancy Shop Boutique was very good, and marketing communication about customer value at Alisha Fancy Shop Boutique had a very significant positive effect of 27.1%. We can conclude that Marketing Communication creates Customer Value very well. Because the results of the study explain the relationship between marketing communication and customer value, it is recommended for Alisha Fancy Shop Boutique to maintain the marketing strategy that has been carried out.
Abstrak - Komunikasi pemasaran yang dikenal saat ini merupakan salah satu strategi yang perlu diperhatikan oleh perusahaan karena satu atau lebih tahapan proses yang tidak dapat diabaikan begitu saja dari proses bisnis perusahaan. Lebih lanjut disampaikan bahwa sebaik apapun rencana strategi pemasaran bila tidak didukung denga komunikasi yang baik melalui komunikasi pemasaran maka hasilnya tidak akan optimal. Menelaah dari fenomena atas komunikasi pemasaran maka penelitian ini fokus mengkaji implementasi dari komunikasi pemasaran. Penelitian yang dilakukan fokus pada satustudi kasus perusahaan yaitu Alisha Fanshy Shop Boutique, dimana dikaji terkait komunikasi pemasaran yang dilakukan adapun teknik pengambilan sample dilakukan dengannon-probabilitas. Karena penelitian ini termasuk pada penelitian kuantitatif, maka analisis data yang dikerjakan dengan pendekatan alisis regresi. Hasil penelitian menunjukkan bahwa bagian dari komunikasi pemasaran di Alisha Fancy Shop Boutique sangat baik, nilai pelanggan di Alisha Fancy Shop Boutique sangat baik, dan komunikasi pemasaran tentang nilai pelanggan di Alisha Fancy Shop Boutique memiliki pengaruh positif sangat signifikan 27,1%. Kita dapat menyimpulkan bahwa Komunikasi Pemasaran menciptakan Nilai Pelanggan dengan sangat baik. Karena hasil penelitian menjelaskan adanya hubungan antara komunikasi pemasaran dengan nilai pelanggan, maka disaranlan untuk Alisha Fancy Shop Boutique mempertahankan strategi pemasaran yang telah dilakukan.
Pengembangan Lembar Kegiatan Peserta Didik Berbasis Group Investigation Untuk Menguatkan Karakter Peserta Didik Dalam Memecahkan Masalah
Authors: Assalam Imam Ridho , Sriyono Sriyono , Nurhidayati Nurhidayati 
Published: June 2022

Telah dilakukan penelitian pengembangan LKPD berbasis Group Investigation guna (1) mengembangkan lembar kegiatan peserta didik, (2) mengetahui kelayakan LKPD yang dikembangkan dan respon peserta didik (3) menguatkan karakter peserta didik. Jenis penelitian ini pengembangan yang mengacu model ADDIE [6]. Penelitian dilaksanakan di SMA Negeri 6 Purworejo. Hasil analisis data yaitu: (1) Validasi LKPD berbasis Group Investigation dari tiga validator mendapatkan 3,45 dengan kategori cukup baik dan uji reliabilitas sebesar 95,6% dengan kategori reliabel. (2) Tanggapan peserta didik terhadap LKPD berbasis Group Investigation pada uji coba terbatas 77,5% dengan klasifikasi baik dan uji coba luas 84,3% dengan klasifikasi baik. (3) Menguatkan karakter pada peserta didik pada aspek jujur mendapatkan nilai rata-rata 3,13 dengan klasifikasi cukup baik, aspek toleransi mendapatkan nilai rata-rata 3,02 dengan klasifikasi cukup baik, aspek bekerjasama mendapatkan nilai rata-rata 3,03 dengan klasifikasi cukup baik sehingga LKPD fisika berbasis Group Investigation dapat dijadikan lembar kerja alternatif dalam proses pembelajaran untuk menguatkan karakter peserta didik.
Analisis Pemahaman Konsep Fisika Berbasis Model Pembelajaran Group Investigation-Guided Inquiry (GI-GI) Peserta Didik Kelas X SMA
Authors: Nurdiyani Tri Fatma , Ashari Ashari , Fatmaryanti Siska Desy 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui: (1) pemahaman konsep peserta didik dengan menggunakan model pembelajaran (GI-GI) (2) pengaruh model pembelajaran GI-GI terhadap pemahaman konsep peserta didik. Penelitian ini adalah penelitian Quasi Eksperimen dengan jenis nonequivalent Control Group Design. Populasi pada penelitian ini adalah peserta didik kelas X MIPA SMA N 1 Karanganyar. Sampel penelitian terdiri dari kelas X MIPA 2 sebagai kelas eksperimen yang diberi pembelajaran dengan menggunakan model pembelajaran Group Investigation-Guided Inquiry (GI-GI) dan kelas X MIPA 1 sebagai kelas kontrol yang diberi pembelajaran dengan menggunakan model pembelajaran yang diterapkan pada sekolah. Berdasarkan hasil perhitungan diperoleh: (1) Rata-rata tingkat pemahaman konsep peserta didik sebelum diberi perlakuan kedua kelas dalam kategori rendah dengan rata-rata persentase kelas eksperimen sebesar 16% lebih rendah dibanding kelas kontrol yaitu 18%. Setelah diberikan perlakuan meningkat menjadi 64% untuk kelas eksperimen dan 52% untuk kelas kontrol. Tingkat pemahaman konsep tiap indikator pada kelas eksperimen yaitu indikator menafsirkan 44%, merangkum 52%, menyimpulkan 42%, membandingkan 56%, mencontohkan 87%, mengklasifikasikan 71%, dan menjelaskan 97%. Adapun pemahaman konsep kelas kontrol pada indikator merangkum 28%, menafsirkan 31%, mencontohkan 50%, menyimpulkan 41%, membandingkan 56%, mengklasifikasikan 66% dan menjelaskan 91%. (2) Hasil nilai N-Gain kelas eksperimen lebih tinggi yaitu 0,71 yang termasuk kriteria tinggi dan 0,66 termasuk pada kriteria sedang. Hipotesis dilakukan dengan menggunakan uji t diperoleh nilai thitung = 2,9834 dan ttabel = 1,9996 dengan taraf signifikasi 0,05. Hasil tersebut menunjukan bahwa terdapat peningkatan pemahaman konsep secara signifikan menggunakan model pembelajaran Group Investigation-Guided Inquiry (GI-GI).
Perancangan Alat Peraga Momen Kelembaman Bola Pejal Berbasis Multirepresentasi dengan Sensor Garis
Authors: Anisah Farida Nur , Fatmaryanti Siska Desy , Pratiwi Umi 
Published: June 2022

Pembelajaran gerak melingkar pada subab momen kelembaman kebayakan pembelaran teori dalam bentuk teori, kurangnya domain psikomotor dari teori ke praktek sehingga mahasiswa kurang memahami konsep pada materi momen kelembaman. Desain penelitian pengembangan dan eksperimen fisika. Penelitian ini dilaksanakan di Universitas Muhamadiyah Purworejo. Instrumen yang digunakan dalam penelitian ini adalah lembar validasi alat peraga, lembar validasi buku panduan dan petunjuk, lembar validasi soal berbasis multirepresentasi. Hasil penelitian diperoleh: (1) hasil pengujian alat peraga penentuan momen kelembaman bola pejal pada kelereng diperoleh nilai K untuk jarak tetap 3 meter sebesar (0,415 ± 0,057), untuk jarak 2 meter sebesar (0,414 ± 0,057), dan untuk jarak 1 meter (0,405 ± 0,056). Hasil pengujian alat pada bola bekel diperoleh nilai K untuk jarak tetap 3 meter sebesar (0,566 ± 0,060), (0,570 ± 0,056) untuk jarak 2 meter sebesar, dan untuk jarak 2 meter sebesar ( 0,596 ± 0,071). (2) hasil validasi alat peraga penentuan momen kelembaman pada ahli materi sebesar 3,26 dengan presentase 82% termasuk kedalam kategori baik, pada ahli media sebesar 3,28 dengan presentase 83% termasuk kedalam kategori baik, dan validasi soal berbasis multirepresentasi memperoleh skor 2,92 dengan presentase 73% termasuk kedalam kategori baik