bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-Wrinkle Efficacy of Edible Bird’s Nest Extract: A Randomized, Double-Blind, Placebo-Controlled, Comparative Study
Authors: Kim Hyung Mook , Lee Yong Moon , Kim Ee Hwa , Eun Sang Won , Sung Hyun Kyung , Ko Heung , Youn Sang Jun , Choi Yong , Yamada Wakana , Shin Seon Mi 
Published: March 2022

This study aimed to evaluate skin health’s functional improvement, such as wrinkles, elasticity, moisture, and whitening, and safety following the consumption of “edible bird’s nest extract” for 12 weeks by women. This single-center, double-blinded, parallel-group, placebo-controlled study included women aged 40–60 years. Our primary purpose was to assess improvement in skin wrinkles, elasticity, and moisture after 12 weeks using an SV700, cutometer, and corneometer, respectively, compared to baseline measurements. Our secondary purpose was to evaluate skin wrinkle, elasticity, and moisture changes at 4 and 8 weeks from baseline using the aforementioned equipment, and measure transdermal water loss and melanin and erythema indexes using a tewameter and mexameter, respectively. Experts performed the visual evaluation of skin wrinkles at 4, 8, and 12 weeks from baseline. The participants were randomly allocated in a 1:1 ratio into the edible bird’s nest extract or the placebo group with 43 participants each, where they consumed 100 mg of the extract or placebo, respectively, daily for 12 weeks. The outcomes were measured at every visit. In this study, upon comparing changes in the skin elasticity value between the two intake groups at 12 weeks of ingestion, skin elasticity in the edible bird’s nest extract group decreased significantly compared with that in the placebo group. Adverse reactions were absent in both groups. In the case of laboratory test results, changes before and after the ingestion of the extract were within the normal range, thus indicating no clinically significant difference. The edible bird’s nest extract was effective in improving skin wrinkles. Moreover, it is beneficial for skin health and can be used as a skin nutritional supplement. Compared with the placebo, the edible bird’s nest extract was identified as safe.Clinical Trial Registration:https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&amp;search_page=M&amp;pageSize=10&amp;page=undefined&amp;seq=21007&amp;status=5&amp;seq_group=20330, identifier KCT0006558.
Safety Profile of Antipsychotic Drugs: Analysis Based on a Provincial Spontaneous Reporting Systems Database
Authors: Guo Kangyuan , Feng Zhanchun , Chen Shanquan , Yan Ziqi , Jiao Zhiming , Feng Da 
Published: March 2022

Introduction: Antipsychotic drugs are the main therapy for schizophrenia and have been widely used in mental disorder fields. However, the research on the safety of antipsychotic drugs in the real-world is rare. The purpose of this research is to evaluate the safety of antipsychotic drugs based on real-world data.Methods: ADR reports collected by the Henan Adverse Drug Reaction Monitoring Center from 2016 to 2020 were analyzed. We described the safety of antipsychotic drugs by descriptive analysis and four signal mining methods. Meanwhile, the risk factors for serious adverse reactions of antipsychotics were identified.Results: A total of 3363 ADR reports related to antipsychotics were included. We found that the number of adverse drug reaction reports and the proportion of serious adverse reactions have increased year by year from 2016 to 2020. Most adverse drug reactions occurred within 3 months after taking the medicine. The symptoms caused by typical antipsychotics and atypical antipsychotics were different and dyskinesia was more common in typical antipsychotics. Most patients improved or recovered after treatment or intervention while only one patient had sequelae. Low-level hospitals, psychiatric hospitals, youth, and old age could increase the risk of serious adverse reactions. Four off-label signals were found through signal mining, including amisulpride-pollakiuria, ziprasidone-dyspnoea, quetiapine-urinary incontinence, olanzapine-hepatic function abnormal.Conclusion: We found that most ADRs occurred within 3 months after taking the medicine, so close observation was required for patients during the first 3 months of treatment. The ADRs of antipsychotics involved multiple organ-system damages but were not serious. It might be recommended to take alternative drugs after a serious ADR occurred. The symptoms caused by typical APDs and atypical APDs were different. For patients with typical APDs, dyskinesia was more common and should be given special attention. Statistics showed that low-level hospitals, psychiatric hospitals, youth, and old age were risk factors for serious ADRs. The four off-label signals obtained by signal mining should be paid special attention, including amisulpride-pollakiuria, ziprasidone-dyspnoea, quetiapine-urinary incontinence, and olanzapine-hepatic function abnormal.
Affective and Enjoyment Responses to Sprint Interval Training in Healthy Individuals: A Systematic Review and Meta-Analysis
Authors: Hu Mingzhu , Jung Mary E. , Nie Jinlei , Kong Zhaowei 
Published: March 2022

Sprint interval training (SIT) is characterized by intensity of “all-out” effort and superior time-efficiency compared to traditional moderate-intensity continuous training (MICT) and has been proposed as one viable solution to address the commonly reported barrier of lack of time for physical activity. While substantial physiological benefits of participation in SIT have been well-documented, the psychological responses to SIT are less clear. No systematic review has been conducted thus far to respond to the assumption that its supramaximal intensity will induce adverse feelings. Therefore, the aim of the present study was to synthesize studies analyzing affective and enjoyment responses to SIT and to compare the responses to SIT with MICT and other high intensity interval training (HIIT) protocols with lower intensities. After searching relevant databases up until 22nd March 2021, twenty-five studies meeting the inclusion criteria were included in the present review. Random effect meta-analysis using the pooled data demonstrated that SIT induced similar post-exercise affective valences during the training compared to MICT and HIIT, but lower affective valences immediately post-exercise compared to MICT. Moreover, affective responses during SIT decreased to negative valences according to the results from most included studies, while low-volume SIT protocols with shorter sprint duration and repetitions induced more positive affective responses. Level of enjoyment after SIT were positive and were comparable to MICT or HIIT. Overall, the results from the existing literature indicate that SIT might cause unpleasant feelings during the training and be perceived less pleasurable than MICT immediately post training but could be a comparably enjoyable modality for healthy individuals in relation to MICT or HIIT, despite its supramaximal intensity. Low-volume SIT may be a realistic option for individuals seeking a time-efficient workout with comparable affective responses to MICT or HIIT.Systematic Review Registration[https://www.crd.york.ac.uk/PROSPERO], Identifier [CRD42021284898].
A Systematic Review: The Effect of Cancer on the Divorce Rate
Authors: Fugmann Dominik , Boeker Martin , Holsteg Steffen , Steiner Nancy , Prins Judith , Karger André 
Published: March 2022

IntroductionResearch on the impact of cancer on close relationships brings up conflicting results. This systematic review collects empirical evidence on the research questions whether a cancer diagnosis in general or the type of cancer affects the divorce rate.Materials and MethodsThis systematic review was conducted according to the guidelines of the Cochrane Collaboration and the PRISMA statement. The following electronic databases were searched: Web of Science, Ovid SP MEDLINE, PsycINFO, PsyINDEX, CINAHL, ERIC. Risk of bias assessment was performed with the preliminary risk of bias for exposures tool template (ROBINS-E tool). The grading of methodological quality was assessed with the Newcastle-Ottawa Scale.ResultsOf 13,929 identified records, 15 were included in the qualitative synthesis. In 263,616 cancer patients and 3.4 million healthy individuals, we found that cancer is associated with a slightly decreased divorce rate, except for cervical cancer, which seems to be associated with an increased divorce rate.DiscussionAccording to this systematic review, cancer is associated with a tendency to a slightly decreased divorce rate. However, most of the included studies have methodologic weaknesses and an increased risk of bias. Further studies are needed.
Prevalence of Sleep Problems Among Chinese Medical Students: A Systematic Review and Meta-Analysis
Authors: Sun Yuanlong , Wang Huiying , Jin Tao , Qiu Fei , Wang Xiaolong 
Published: March 2022

BackgroundSleep is a necessary physiological process, which is closely related to cognitive function, emotion, memory, endocrine balance, and immunity. The prevalence of sleep problems continues to rise in Chinese medical students, which has a potential influence on living and work.ObjectiveThis study aimed to observe the prevalence of sleep problems among medical students in China.MethodThe included cross-sectional studies on the prevalence of sleep problems of medical students in China were retrieved from PubMed, Embase, the Cochrane Database of Systematic Reviews, CNKI, and Wanfang database. An 11-item checklist recommended by the Agency for Healthcare Research and Quality was adopted to evaluate the methodological quality of the included studies. Software Stata 12.0, SPSS 26.0, and R were used to analyze the data. Registration: PROSPERO, CRD 42021237303.ResultThe prevalence of sleep problems among Chinese medical students was 27.38%. The subgroup analysis showed significant differences in the prevalence of sleep problems among different regions, educational backgrounds, grades, and University types. The region, latitude, and gross domestic product (GDP) were significant heterogeneous sources of sleep problems. The prevalence is positively correlated with latitude and negatively correlated with GDP per capita. Regular screening and appropriate intervention are recommended for these mental health problems.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021237303, identifier: CRD42021237303.
Game Addiction Scale for Adolescents—Psychometric Analyses of Gaming Behavior, Gender Differences and ADHD
Authors: André Frida , Munck Ingrid , Håkansson Anders , Claesdotter-Knutsson Emma 
Published: March 2022

BackgroundInternet gaming disorder (IGD) was recently added in the Diagnostic and Statistical Manual of Mental Disorder as a “condition for further studies.” There is no consensus regarding which rating scales should be used but many scholars suggest the GASA (Game Addiction Scale for Adolescents) and a ranking of the criteria, “the core approach” to avoid over-diagnosing of disordered gaming. Male gender and ADHD are commonly listed as risk factors for disordered gaming but little is known about sex differences in gaming and gender specific health correlates.PurposeThe present study aims to evaluate the core approach and the specific indicators of gaming behavior in GASA from a multifactorial perspective and explore the gender differences in a clinical setting, focusing on ADHD.Patients and MethodsChildren and adolescents aged 8–18 years (n = 144) from Child and adolescent psychiatry (CAP) in Skane were assessed with the GASA. Psychometric analyses including confirmatory factor analyses (CFA) and structural equation modeling (SEM) were used to identify well-defined constructs and gender differences. Refined factor scores for single constructs were the outcome of alignment, a procedure for assessing measurement equivalence across gender. New model-based gaming behavior variables were used for descriptive statistics and ANOVA testing of gender differences.ResultsThe results confirm that the core approach two-factor model is valid for the CAP sample, as well as a theory based psycho-social model for gaming behavior with over consumption and negative social and emotional consequences. Our findings suggest that negative consequences of over consumption take a social direction for boys and an emotional direction for girls. Also, ADHD was significantly associated with over consumption of video games and the negative consequences thereof for girls.ConclusionGuided by psychometric analyses, the GASA could be strengthened by advancing the questionnaire design and by adding complementary items in order to illuminate the complexity of gaming behavior. Our findings suggest that additional research on potential gender related discrepancies of disordered gaming is needed.
Sociodemographic and Occupational Factors Associated With Burnout: A Study Among Frontline Healthcare Workers During the COVID-19 Pandemic
Authors: Aljabri Duaa , Alshatti Fatimah , Alumran Arwa , Al-Rayes Saja , Alsalman Deema , Althumairi Arwa , Al-kahtani Nouf , Aljabri Mohammad , Alsuhaibani Shaheed , Alanzi Turki 
Published: March 2022

PurposeTo describe the prevalence of burnout among frontline healthcare workers (HCWs) during the COVID-19 pandemic and the associated sociodemographic and occupational factors.MethodsA cross sectional survey study was carried out to study HCWs burnout using the 19-item Full Copenhagen Burnout Inventory (CBI) that includes personal, work, and patient-related burnout subscales. Bivariate analysis was used to test for associations and p &lt; 0.05 was considered statistically significant.ResultsA total of 207 responses received; where the mean score of personal burnout was 67.23, the mean of work-related burnout was 61.38, and the mean of patient-related burnout was 54.55. Significant associations were found; where female HCWs, those working in rotating day-and-night shifts, working more than 55-h per week, and who had their shift time and hours changed during the pandemic, had higher levels of personal and work-related burnout (P &lt; 0.05). Patient-related burnout was higher among those who were single (divorced or separated), nurses, non-Citizens, those with fewer years of experience, and who were infected by COVID-19 and have been quarantined (P &lt; 0.05). Age was not a significant factor of burnout in any of the CBI subscales.ConclusionsThere is a prevalent level of burnout among frontline HCWs during the COVID-19 pandemic. Findings highlight key sociodemographic and occupational factors affecting burnout; which can help planning for psychological support strategies. Furthermore, effective administrative control is important to institute policies and mechanisms to identify, and freely report burnout symptoms among HCWs to promote their wellbeing.
Advanced Intrusion Detection Combining Signature-Based and Behavior-Based Detection Methods
Authors: Kwon Hee-Yong , Kim Taesic , Lee Mun-Kyu 
Published: March 2022

Recently, devices in real-time systems, such as residential facilities, vehicles, factories, and social infrastructure, have been increasingly connected to communication networks. Although these devices provide administrative convenience and enable the development of more sophisticated control systems, critical cybersecurity concerns and challenges remain. In this paper, we propose a hybrid anomaly detection method that combines statistical filtering and a composite autoencoder to effectively detect anomalous behaviors possibly caused by malicious activity in order to mitigate the risk of cyberattacks. We used the SWaT dataset, which was collected from a real water treatment system, to conduct a case study of cyberattacks on industrial control systems to validate the performance of the proposed approach. We then evaluated the performance of the proposed hybrid detection method on a dataset with two time window settings for the composite autoencoder. According to the experimental results, the proposed method improved the precision, recall, and F1-score by up to 0.008, 0.067, and 0.039, respectively, compared to an autoencoder-only approach. Moreover, we evaluated the computational cost of the proposed method in terms of execution time. The execution time of the proposed method was reduced by up to 8.03% compared to that of an autoencoder-only approach. Through the experimental results, we show that the proposed method detected more anomalies than an autoencoder-only detection approach and it also operated significantly faster.
Clinico-Morphological and Biomechanical Aspects Damage of Soft Tissue and Bone Facial Region
Authors: Артюшкевич А.С. , Артюшкевич В.С. 
Published: March 2022

Клиника, диагностика, судебно-медицинские аспекты травм лица и челюстей, включающие особенности биомеханики, характер повреждений, степень тяжести повреждений, занимают значительное место в работе клинициста и судебного медицинского эксперта.Среди различных видов повреждений челюстно-лицевой области основное место занимают механические травмы (85%). К повреждениям мягких тканей относятся ушибы, ссадины, раны, которые нередко сочетаются с переломами костей лицевого скелета, чаще всего с переломами зубов, нижней челюсти. Патоморфология ран лица характеризуется сосудистыми, клеточными реакциями различной степени выраженности.Клинические проявления переломов зубов, нижней и верхней челюсти зависят во многом от силы, направления удара, места приложения силы. Все многообразие механизмов переломов сводится к сгибанию и разгибанию костей, сдвигу, сжатию, отрыву. Компетентность судебно-медицинского эксперта, врача – челюстно-лицевого хирурга в области биомеханики, морфологии травм позволит дать аргументированные ответы на вопросы, связанные с тяжестью травмы, видами ранящего орудия, давностью травмы, ее прижизненностью и выбором адекватного лечения.
Clinic, diagnostics, forensic aspects of injuries to the face and jaws, including biomechanics, the nature of injuries, the severity of injuries, occupy a significant place in the work of a clinician and forensic physician.Among the various types of damage to the maxillofacial region, mechanical injuries occupy the main place, 85%. Injuries to soft tissues include bruises, abrasions, wounds, which are often combined with fractures of the bones of the facial skeleton, most often with fractures of the teeth and lower jaw. Pathomorphology of wounds is characterized by vascular, cellular reactions.Clinical manifestations of fractures of the teeth, lower and upper jaw depends largely on the strength and direction of the impact. The whole variety of fracture mechanisms is reduced toflexion and extension of bones, shift, compression, separation. The competence of a forensic expert, a maxillofacial surgeon in the field of biomechanics, morphology of injuries will make it possible to give reasoned answers to questions related to the severity of injury, types of injuring instruments, duration of injury, its lifetime, etc.
Relationship of Surfactant Protein A Level in Blood Serumwith Clinical Manifestation of Pneumonia in Newborn Children
Authors: Журавлева Л.Н. 
Published: March 2022

На современном этапе проблема инфекционных заболеваний дыхательной системы у новорожденных является актуальной, что связано с высоким уровнем заболеваемости и частоты осложнений у детей грудного возраста и новорожденных.Цель исследования: оценка содержания SP-А в сыворотке крови у новорожденных с врожденной пневмонией.Мы наблюдали 27 недоношенных новорожденных с врожденной пневмонией, группу сравнения составили 20 «условно здоровых» новорожденных без трахеобронхиальной патологии. Содержание SP-А в группе «условно здоровых» недоношенных составило 48,4 нг/мл (25–75 IQR 35,7–64,3 нг/мл). Концентрация SP-А в плазме пациентов с врожденной пневмонией была 35,78 нг/мл (25–75 IQR 25,57–41,63 нг/мл) в течение как 1–2 суток, так и в последующем на 10– 14-е сутки исследования достоверно выше (р<0,001), чем у недоношенных без респираторных заболеваний. Мы выявили положительную корреляционную связь между тяжестью течения пневмонии и повышением уровня SP-А в сыворотке на 1–2-е сутки жизни у пациентов с неблагоприятным исходом пневмонии (r=0,378, p<0,0001). Также мы определили, что уровень SP-А в сыворотке крови недоношенных новорожденных 56,5 нг/мл может служить диагностическим критерием прогностически неблагоприятного течения врожденной пневмонии. Таким образом, повышенный уровень в крови сурфактантного белка А при врожденной пневмонии может быть новым значимым биомаркером этого заболевания и отражать активный воспалительный процесс и степень повреждения легких.
Presently the problem of infectious diseases of the respiratory system in newborns is urgent, because it is associated with a high incidence and frequent complications in infants and newborns. The purpose of the work was to assess the level of SP-A in the blood serum of newborns with congenital pneumonia.We observed 27 premature infants with congenital pneumonia, the comparison group consisted of 20 “almost healthy” newborns without tracheobronchial pathology.The content of SP-A in the group of “almost healthy” premature infants was 48.4 ng / ml (25–75 IQR 35.7–64.3 ng/ml). The concentration of SP-A in the plasma of patients with congenital pneumonia was 35.78 ng/ml (25–75 IQR 25.57–41.63 ng/ml) for 1–2 days of life and then on days 10–14days is significantly higher (p<0.001) than in premature infants without respiratory diseases. We found a positive correlation between the severity of pneumonia and an increased SP-A serum levels on 1–2 days of life in patients with unfavorable outcomes of pneumonia (r=0.378, p<0.0001). We also determined that the SP-A level in the blood serum of premature infants of 56.5 ng/ml can serve as diagnostic criteria for the prognostically unfavorable duration of congenital pneumonia. Thus, the increased level of surfactant protein A in the blood in congenital pneumonia may be a new significant biomarker of this disease and reflect an active inflammatory process and the degree of lung damage.