bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment
Authors: Climie Rachel E. , Tafflet Muriel , Sloten Thomas van , Lauzon-Guillain Blandine de , Bernard Jonathan Y. , Dargent-Molina Patricia , Plancoulaine Sabine , Lioret Sandrine , Jouven Xavier , Charles Marie-Alines , Heude Barbara , Empana Jean-Philippe 
Published: April 2022

BackgroundEarly childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and to compare the level of cognitive development between children with and without ideal CVH at age 5 years.MethodsUsing data from the Etude sur les déterminants pré et post natals précoces du Développement psychomoteur et de la santé de l'Enfant (EDEN) study, a French population-based mother–child cohort study, CVH was examined in children at 5 years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels, and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (five to six ideal metrics) or non-ideal CVH (&lt;5 ideal metrics). Intelligence quotient (IQ) at age 5 years was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence.ResultsAmong the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR = 1.77, 95% CI 1.13–2.78), children with intermediate (1.77, 1.05–2.98) or ideal (2.58, 1.38–4.82) behavioral CVH at age 3 years and children who spent &lt; 30 min/day watching television (1.91, 1.09–3.34) at age 3 years were more likely to have ideal CVH at age 5 years. At age 5 years, there was a significant 2.98-point difference (95% CI 0.64–5.32) in IQ between children with and without ideal biological CVH after adjusting for confounders.ConclusionThis study highlights that only a third of children aged 5 years had ideal CVH and identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.
Scaling Beyond Cities
Authors: Prieto Curiel Rafael , Cabrera-Arnau Carmen , Bishop Steven Richard 
Published: April 2022

City population size is a crucial measure when trying to understand urban life. Many socio-economic indicators scale superlinearly with city size, whilst some infrastructure indicators scale sublinearly with city size. However, the impact of size also extends beyond the city’s limits. Here, we analyse the scaling behaviour of cities beyond their boundaries by considering the emergence and growth of nearby cities. Based on an urban network from African continental cities, we construct an algorithm to create the region of influence of cities. The number of cities and the population within a region of influence are then analysed in the context of urban scaling. Our results are compared against a random permutation of the network, showing that the observed scaling power of cities to enhance the emergence and growth of cities is not the result of randomness. By altering the radius of influence of cities, we observe three regimes. Large cities tend to be surrounded by many small towns for small distances. For medium distances (above 114 km), large cities are surrounded by many other cities containing large populations. Large cities boost urban emergence and growth (even more than 190 km away), but their scaling power decays with distance.
Prospective Study on Dynamic Postural Stability in Youth Competitive Alpine Skiers: Test-Retest Reliability and Reference Values as a Function of Sex, Age and Biological Maturation
Authors: Kiers Kirsten , Ellenberger Lynn , Jermann Julia , Oberle Felix , Frey Walter O. , Spörri Jörg 
Published: April 2022

This study aimed 1) to assess the test-retest reliability of dynamic postural stability index (DPSI) assessments using a ski-specific jump protocol that consists of single-leg landings on a three-dimensional force plate after forward-performed double-leg drop jumps from a box over a hurdle (DJSLLs), 2) to provide reference values for female and male youth competitive alpine skiers; 3) to explore their changes in DPSI over 3 years during adolescence; and 4) to investigate potential associations of DPSI with age and biological maturation. Using three-dimensional force plates, 16 healthy subjects were tested on the same day (test-retest reliability experiment; five test-retest assessments of right leg landings), and 76 youth skiers aged 13–15 years were tested 3 times within 2 years (main experiment; average of two trials per leg each time). The test-retest reliability experiment revealed an ICC(3,1) and 95% CI of 0.86 [0.74, 0.94] for absolute DPSI assessment. The within-subject SEM of absolute DPSI was 16.30 N [13.66 N, 20.65 N], and the standardized typical error was moderate (0.39 [0.33, 0.50]). Both absolute and relative DPSI values were comparable between male and female youth competitive alpine skiers. The mean absolute DPSI in year 1 (195.7 ± 40.9 N), year 2 (196.5 ± 38.9 N) and year 3 (211.5 ± 41.3 N) continuously increased (i.e., worsened) (p &lt; 0.001). Mean relative, i.e. body weight force normalized, DPSI values significantly decreased, i.e., improved, from year 1 to 2 (0.42 ± 0.01 vs. 0.36 ± 0.004; p &lt; 0.001) and year 1 to 3 (0.42 ± 0.01 vs. 0.36 ± 0.01; p &lt; 0.001). Absolute DPSI correlated with age and biological maturation, while no such correlations were found for relative DPSI values. Our findings suggest that DPSI is a reliable and sensitive measure of dynamic postural control during DJSLLs and that relative DPSI improves annually in competitive youth skiers when accounting for body weight. Future work should consider biological maturation testing during the growth spurt, and normalizing to body weight force could be a possible solution.
Childhood Trauma and Cortisol Reactivity: An Investigation of the Role of Task Appraisals
Authors: Counts Cory J. , Ginty Annie T. , Larsen Jade M. , Kampf Taylor D. , John-Henderson Neha A. 
Published: April 2022

BackgroundChildhood adversity is linked to adverse health in adulthood. One posited mechanistic pathway is through physiological responses to acute stress. Childhood adversity has been previously related to both exaggerated and blunted physiological responses to acute stress, however, less is known about the psychological mechanisms which may contribute to patterns of physiological reactivity linked to childhood adversity.ObjectiveIn the current work, we investigated the role of challenge and threat stress appraisals in explaining relationships between childhood adversity and cortisol reactivity in response to an acute stressor.MethodsUndergraduate students (n = 81; 61% female) completed an online survey that included general demographic information and the Risky Families Questionnaire 24 h before a scheduled lab visit. In the lab, a research assistant collected a baseline salivary cortisol sample. Following the baseline period, participants were read instructions for the Trier Social Stress Test (TSST), a validated psychological lab stressor. Next, they completed a challenge vs. threat task appraisal questionnaire and completed the speech and math portion of the TSST. Twenty minutes following the start of the TSST, a second salivary sample was collected to measure changes in salivary cortisol following the TSST.ResultsLinear regression analyses adjusted for age, sex, childhood socioeconomic status (SES), and baseline cortisol levels, showed childhood adversity associated with changes in cortisol levels [B = –0.29 t(73) = –2.35, p = 0.02, R2=0.07]. Linear regression analyses controlling for age, sex, and childhood SES showed childhood adversity associated with both challenge [B = –0.52 t(74) = –5.04, p &lt; 0.001, R2=0.24] and threat [B = 0.55 t(74) = 5.40, p &lt; 0.001, R2=0.27] appraisals. Significant indirect effects of childhood trauma on cortisol reactivity were observed through challenge appraisals [B = –0.01 (95% confidence interval = –0.02, –0.003)], and threat appraisals [B = –0.01 (95% confidence interval = –0.01, –0.003)].ConclusionChildhood adversity may contribute to blunted cortisol reactivity, a pattern of response which is linked to obesity, addiction, and other behavior-related diseases. Our findings suggest that this relationship is in part a product of stress appraisals.
Interoception Dysfunction Contributes to the Negative Emotional Bias in Major Depressive Disorder
Authors: Zhou Hongliang , Zou Haowen , Dai Zhongpeng , Zhao Shuai , Hua Lingling , Xia Yi , Han Yingling , Yan Rui , Tang Hao , Huang Yinghong , Du Yishan , Wang Xiaoqin , Yao Zhijian , Lu Qing 
Published: April 2022

BackgroundPrevious research studies have demonstrated that impaired interoception is involved in emotional information processing in major depressive disorder (MDD). Heartbeat-evoked potential (HEP) amplitudes, an index for interoception, could be manipulated by emotional faces in healthy people. Considering negative emotional bias is the core characteristic in MDD, we hypothesized that interoception dysfunction was associated with the negative emotional bias in MDD.MethodsAn electroencephalogram (EEG) study under an emotional faces task was applied to explore the relationship between interoception and emotional bias. HEPs before emotional faces stimuli were used to predict the late positive potential (LPP) amplitudes and it worked as an index of emotional bias. Twenty-seven patients with MDD and 27 healthy controls (HCs) participated in this study. Source analysis gave an auxiliary description for results in sensory level.ResultsMajor depressive disorders (MDDs) had poor performance in the heartbeat count task (HCT) and attenuate HEP average amplitudes (455–550 ms). Compared with HCs, cluster-based permutation t-tests revealed that MDDs had attenuated LPP amplitudes (300–1,000 ms) over centroparietal regions and enhanced LPP amplitudes over frontocentral regions. Furthermore, abnormal attenuated HEPs could predict aberrant LPPs under sad face stimuli in MDDs, which could be associated with the dysfunction of the anterior cingulate cortex (ACC) and right insula.ConclusionMediated by ACC and insula, interoception dysfunction contributes to the negative emotional bias of MDD, highlighting the importance of interoception in the disorder.
Surgical Management of a Giant Desmoid Fibromatosis of Abdominal Wall With Vessels Invasion in a Young Man: A Case Report and Review of the Literature
Authors: Zhao Jiming , Cheng Fajuan , Yao Zhigang , Zheng Bin , Niu Zhihong , He Wei 
Published: April 2022

BackgroundDesmoid fibromatosis (DF) is a rare clonal proliferation of fibroblasts and myofibroblasts. It develops in the connective tissues and does not metastasize but may infiltrate adjacent structures. Because of the rarity of these tumors and the unpredictable natural history of the disease, well-defined and precise guidelines of the optimal treatment for DF have not been formulated.Case PresentationHere, we present a giant abdominal DF that invaded the right spermatic cord and iliac vessels. The lesion was excised with external iliac artery dissection; however, the vein was sacrificed. The abdominal wall defect was then repaired with a polypropylene mesh. The lesional cells are positive for β-catenin.ConclusionsIn the past decades, there has been a change in the treatment of DF. The “wait and see” policy has been considered initially in most cases. Surgical intervention remains a valid option for symptomatic lesions. The optimal regimes of the tumor should not take the risk of making the patient more symptomatic than the lesion itself.
Identification of Bladder Cancer Subtypes Based on Necroptosis-Related Genes, Construction of a Prognostic Model
Authors: Nie Shiwen , Huili Youlong , He Yadong , Hu Junchao , Kang Shaosan , Cao Fenghong 
Published: April 2022

BackgroundNecroptosis is associated with the development of many tumors but in bladder cancer the tumor microenvironment (TME) and prognosis associated with necroptosis is unclear.MethodsWe classified patients into different necroptosis subtypes by the expression level of NRGS (necroptosis-related genes) and analyzed the relationship between necroptosis subtypes of bladder cancer and TME, then extracted differentially expressed genes (DEGS) of necroptosis subtypes, classified patients into different gene subtypes according to DEGS, and performed univariate COX analysis on DEGS to obtain prognosis-related DEGS. All patients included in the analysis were randomized into the Train and Test groups in a 1:1 ratio, and the prognostic model was obtained using the LASSO algorithm and multivariate COX analysis with the Train group as the sample, and external validation of the model was conducted using the GSE32894.ResultsTwo necroptosis subtypes and three gene subtypes were obtained by clustering analysis and the prognosis-related DEGS was subjected to the LASSO algorithm and multivariate COX analysis to determine six predictors to construct the prognostic model using the formula: riskScore = CERCAM × 0.0035 + POLR1H × −0.0294 + KCNJ15 × −0.0172 + GSDMB × −0.0109 + EHBP1 × 0.0295 + TRIM38 × −0.0300. The results of the survival curve, roc curve, and risk curve proved the reliability of the prognostic model by validating the model with the test group and the results of the calibration chart of the Nomogram applicable to the clinic also showed its good accuracy. Necroptosis subtype A with high immune infiltration had a higher risk score than necroptosis subtype B, gene subtype B with low immune infiltration had a lower risk score than gene subtypes A and C, CSC index was negatively correlated with the risk score and drug sensitivity prediction showed that commonly used chemotherapeutic agents were highly sensitive to the high-risk group.ConclusionOur analysis of NRGS in bladder cancer reveals their potential role in TME, immunity, and prognosis. These findings may improve our understanding of necroptosis in bladder cancer and provide some reference for predicting prognosis and developing immunotherapies.
A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior
Authors: Starnes Hannah M. , Rock Kylie D. , Jackson Thomas W. , Belcher Scott M. 
Published: April 2022

Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that are chemically stable, resistant to degradation, and persistent in terrestrial and aquatic environments. Widespread use of PFAS in industrial processing and manufacturing over the last 70 years has led to global contamination of built and natural environments. The brain is a lipid rich and highly vascularized organ composed of long-lived neurons and glial cells that are especially vulnerable to the impacts of persistent and lipophilic toxicants. Generally, PFAS partition to protein-rich tissues of the body, primarily the liver and blood, but are also detected in the brains of humans, wildlife, and laboratory animals. Here we review factors impacting the absorption, distribution, and accumulation of PFAS in the brain, and currently available evidence for neurotoxic impacts defined by disruption of neurochemical, neurophysiological, and behavioral endpoints. Emphasis is placed on the neurotoxic potential of exposures during critical periods of development and in sensitive populations, and factors that may exacerbate neurotoxicity of PFAS. While limitations and inconsistencies across studies exist, the available body of evidence suggests that the neurobehavioral impacts of long-chain PFAS exposures during development are more pronounced than impacts resulting from exposure during adulthood. There is a paucity of experimental studies evaluating neurobehavioral and molecular mechanisms of short-chain PFAS, and even greater data gaps in the analysis of neurotoxicity for PFAS outside of the perfluoroalkyl acids. Whereas most experimental studies were focused on acute and subchronic impacts resulting from high dose exposures to a single PFAS congener, more realistic exposures for humans and wildlife are mixtures exposures that are relatively chronic and low dose in nature. Our evaluation of the available human epidemiological, experimental, and wildlife data also indicates heightened accumulation of perfluoroalkyl acids in the brain after environmental exposure, in comparison to the experimental studies. These findings highlight the need for additional experimental analysis of neurodevelopmental impacts of environmentally relevant concentrations and complex mixtures of PFAS.
COVID-19 Risk Perception, Trust in Institutions and Negative Affect Drive Positive COVID-19 Vaccine Intentions
Authors: Musa Sanjin , Cilovic-Lagarija Seila , Kavazovic Ariana , Bosankic-Cmajcanin Nina , Stefanelli Alberto , Scott Nadia Aleyna , Scherzer Martha , Kiss Zsolt , Bach Habersaat Katrine 
Published: April 2022

Objectives: To investigate country-specific drivers and barriers of positive COVID-19 vaccine intentions in the Federation of Bosnia and Herzegovina (FBiH), one of the two entities comprising Bosnia and Herzegovina.Methods: A cross-sectional study design was used, using an online behavioural insights survey tool adapted to the context of FBiH. Three survey waves, each including approximately 1,000 adults, were conducted in July, September and December 2020. Fixed-effects regression analysis was used to explore the drivers, barriers and attitudes towards accepting a future COVID-19 vaccine.Results: COVID-19 risk perception, trust in health institutions and negative affect were positive predictors of positive COVID-19 vaccine intentions, as were living in urban areas and having a college education (versus having primary or secondary education). Conversely, being female, feeling that the pandemic was overhyped by the media and the country of vaccine production were negative predictors.Conclusion: This study provided snapshots on the state of attitudes regarding a future COVID-19 vaccine acceptance and hesitancy in 2020. These findings provided useful insights into the efforts to introduce and roll out the COVID-19 vaccines in FBiH. Further efforts should focus on better understanding the demographic, cultural and behavioural contexts of COVID-related vaccination perceptions in FBiH.
Air Pollution and Chronic Kidney Disease Risk in Oil and Gas- Situated Communities: A Systematic Review and Meta-Analysis
Authors: Okoye Ogochukwu Chinedum , Carnegie Elaine , Mora Luca 
Published: April 2022

Objective: This systematic review and meta-analysis aimed at synthesising epidemiological data on the association between long-term air pollution and kidney-related outcomes in oil and natural gas (ONG) situated communities.Methods: We synthesised studies using the PRISMA 2020 guideline. We searched databases including Medline, Cochrane Library, CIHANL, CAB Abstracts, Greenlife, African Journal Online, Google Scholar and Web of Science, from inception to April 2021. Heterogeneity across studies and publication bias were assessed.Results: Twenty-five studies were systematically reviewed but only 14 were included in the meta-analysis and categorised based on the outcome studied. Residents of exposed communities have increased risk for Chronic Kidney Disease (CKD) (OR = 1.70, 95% CI 1.44–2.01), lower eGFR (OR = 0.55, 95% CI 0.48–0.67) and higher serum creatinine (OR = 1.39, 95% CI 1.06–1.82) compared to less exposed or unexposed populations. The risks for hypertension and kidney cancer between the two populations were not significantly different.Conclusion: We report an increased risk for CKD and kidney dysfunction in populations residing near petrochemical plants, although from a limited number of studies. The scientific community needs to explore this environment and non-communicable disease relationship, particularly in vulnerable populations.
Struktur Modal,Kepemilikan Institusional dan Investment Opportunity Set (Ios) terhadap Kualitas Laba dengan Voluntory Disclosure Sebagai Variabel Intervening
Authors: Lova Mutiara 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh struktur modal, kepemilikan institusional dan investment opportunity set (ios) terhadap kualitas laba dengan voluntory disclosure sebagai variabel intervening pada perusahaan manufaktur sektor industri yang terdaftar di bursa efek indonesia periode 2016-2020. Sampel dalam penelitian ini berjumlah 40 perusahaan manufaktur sektor industri dengan periode penelitian 5 tahun. Metode analisis yang digunakan dalam penelitian ini adalah analisis regresi data panel dengan hasil Estimasi Fixxed Effect dengan menggunakan Eviews 10.Hasil penelitian ini menunjukan bahwa struktur modal tidak berpengaruh signifikan terhadap kualitas laba dengan voluntory disclosure sebagai variabel intervening dan kepemilikan institusional dan investment opportunity set (ios) berpengaruh signifikan terhadap kualitas laba dengan voluntory disclosure sebagai variabel intervening.
Evaluasi Satellite Precipitation Product (GSMaP, CHIRPS, dan IMERG) di Kabupaten Lampung Selatan
Authors: Pratama Alvin , Agiel Hayim Muhammad , Oktaviana Ade Ayu 
Published: April 2022

The availability of rainfall data is an important requirement in various activities. The limitations of observational data make the satellit precipitation product (SPPs) as an alternative. However, the data must be verified before being used. Verification methods are done by using matric statistic methods such as correlation, error and relative bias. Meanwhile, to see the ability of SPPs in detecting rainfall events, it uses a contingency table method. The purpose of this research is to evaluate the ability of SPPs against observation data. Evaluation of SPPs rainfall data is carried out based on a time scale, namely monthly, 10 daily, and daily. This research uses the data from 2018–2020. On a monthly and 10 daily scale, the CHIRPS data shows excellent linearity and rain detection ability. On a daily scale, IMERG shows better linearity than GSMaP and CHIRPS in every season, with moderate to strong correlation coefficients. However, these data tend to be underestimated with a very large bias. In terms of detecting daily rain, GSMaP tends to be better than CHIRPS and IMERG on every season based on the CSI index. However, in the dry season and transition II, the ability tends to be lower. In general, for the amount of rainfall intensity, the three SPPs data still has a fairly large error against the observation data eventhough the ability to detect rainfall is good.