bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants
Authors: Goc Anna , Niedzwiecki Aleksandra , Ivanov Vadim , Ivanova Svetlana , Rath Matthias 
Published: January 2022

Abstract
Despite vaccine availability, the global spread of COVID-19 continues, largely facilitated by emerging SARS-CoV-2 mutations. Our earlier research documented that a specific combination of plant-derived compounds can inhibit SARS-CoV-2 binding to its ACE2 receptor and controlling key cellular mechanisms of viral infectivity. In this study, we evaluated the efficacy of a defined mixture of plant extracts and micronutrients against original SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants. The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-binding domain (RBD) binding of SARS-CoV-2 to its cellular ACE2 receptor by 90%. In vitro exposure of test pseudo-typed variants to this formula for 1 h before or simultaneously administrated to human pulmonary cells resulted in up to 60% inhibition in their cellular entry. Additionally, this composition significantly inhibited other cellular mechanisms of viral infectivity, including the activity of viral RdRp, furin, and cathepsin L. These findings demonstrate the efficacy of natural compounds against SARS-CoV-2 including its mutated forms through pleiotropic mechanisms. Our results imply that simultaneous inhibition of multiple mechanisms of viral infection of host cells could be an effective strategy to prevent SARS-CoV-2 infection.
Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice
Authors: Maeoka Yujiro , Ferdaus Mohammed Z. , Cornelius Ryan J. , Sharma Avika , Su Xiao-Tong , Miller Lauren N. , Robertson Joshua A. , Gurley Susan B. , Yang Chao-Ling , Ellison David H. , McCormick James A. 
Published: January 2022

Significance Statement
Familial hyperkalemic hypertension (FHHt) results from inappropriate activation of the Na+Cl– cotransporter (NCC). Causative mutations have been identified in the gene encoding Cullin3 (CUL3). Cullin3 with the substrate binding adaptor Kelch-like 3 (KLHL3) forms an E3 ubiquitin ligase that mediates degradation of NCC regulatory kinases. The mechanism by which mutant CUL3 causes FHHt is unclear, but lower abundance of CUL3 and KLHL3 proteins and loss of binding to the CUL3 regulator JAB1 have been implicated. Using several mouse models, we found that mutant CUL3 potently induced KLHL3 degradation. Mice heterozygous for CUL3 and KLHL3 displayed an FHHt-like phenotype. JAB1 disruption mimicked the effects of mutant CUL3 expression. Our data show that reduced functional KLHL3 and CUL3 play a central role in FHHt.

Background
Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) gene cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-Δ9) increases abundance of With-No-Lysine (K) Kinase 4 (WNK4), inappropriately activating sterile 20/SPS-1–related proline/alanine-rich kinase (SPAK), which then phosphorylates and hyperactivates the Na+Cl– cotransporter (NCC). The precise mechanism by which CUL3-Δ9 causes FHHt is unclear. We tested the hypothesis that reduced abundance of CUL3 and of Kelch-like 3 (KLHL3), the CUL3 substrate adaptor for WNK4, is mechanistically important. Because JAB1, an enzyme that inhibits CUL3 activity by removing the ubiquitin-like protein NEDD8, cannot interact with CUL3-Δ9, we also determined whether Jab1 disruption mimicked the effects of CUL3-Δ9 expression.

Methods
We used an inducible renal tubule-specific system to generate several mouse models expressing CUL3-Δ9, mice heterozygous for both CUL3 and KLHL3 (Cul3+/−/Klhl3+/−
), and mice with short-term Jab1 disruption (to avoid renal injury associated with long-term disruption).

Results
Renal KLHL3 was higher in Cul3−/−
mice, but lower in Cul3−/−/Δ9
mice and in the Cul3+/−/Δ9
FHHt model, suggesting KLHL3 is a target for both WT and mutant CUL3. Cul3+/−/Klhl3+/−
mice displayed increased WNK4-SPAK activation and phospho-NCC abundance and an FHHt-like phenotype with increased plasma [K+] and salt-sensitive blood pressure. Short-term Jab1 disruption in mice lowered the abundance of CUL3 and KLHL3 and increased the abundance of WNK4 and phospho-NCC.

Conclusions

Jab1−/−
mice and Cul3+/−/Klhl3+/−
mice recapitulated the effects of CUL3-Δ9 expression on WNK4-SPAK-NCC. Our data suggest degradation of both KLHL3 and CUL3 plays a central mechanistic role in CUL3-Δ9–mediated FHHt.
PERAN GENDER SEBAGAI VARIABEL MODERATING PEMBELAJARAN PERBANKAN SYARIAH, LITERASI KEUANGAN SYARIAH DAN RISK TOLERANCE TERHADAP PERILAKU BERINVESTASI DI BANK SYARIAH
Authors: Zulfiana Vina Nafila , Hakim Luqman 
Published: January 2022

The movement of sharia investment has experienced a significant increase of sharia investors in East Java at the 3 rank of investor national, however students at the Surabaya University only distribute their funds to Islamic banks to the point or limit of saving accounts. The purpose of this study is to analyze the effect of sharia banking learning, sharia financial literacy, and risk tolerance towards investing behavior with gender as a moderating variable in State University Students in Surabaya. The type of research used is a quantitative research. This research uses 200 respondents with collections technique uses questionnaire and test. Data analysis technique uses Structural Equation Modeling (SEM) with the WarpPLS approach by the WarpPLS 6.0 application. The result shows that Islamic banking learning has no effect, Islamic financial literacy and risk tolerance have a highly significant effect on investment behavior at Islamic banks of State University Students in Surabaya, then gender cannot moderate the learning of Islamic banking on investment behavior but simultaneously gender influences on investment behavior, gender can moderate sharia financial literacy in a weakly significant manner and significantly risk tolerance towards investing behavior in Islamic Banks at State University Students in Surabaya.[Pergerakan investasi syariah mengalami peningkatan signifikan dalam jumlah investor syariah di Jawa Timur yaitu berada pada urutan ke-3 skala nasional, namun mahasiswa di Perguruan Tinggi Surabaya hanya menyalurkan dananya pada bank Syariah sebatas rekening tabungan saja. Penelitian ini bertujuan untuk manganalisis pengaruh pembelajaran perbankan syariah, literasi keuangan syariah, dan risk tolerance terhadap perilaku berinvestasi dengan gender sebagai variabel moderating pada Mahasiswa Perguruan Tinggi Negeri di Surabaya. Jenis penelitian yang digunakan adalah penelitian kuantitatif. Penelitian ini menggunakan sampel sebanyak 200 responden dengan teknik pengumpulan data berupa kuesioner dan tes. Teknik analisis data menggunakan Pemodelan Persamaan Struktural (SEM) dengan pendekatan WarpPLS berbantuan aplikasi WarpPLS 6.0. Hasil Penelitian menunjukkan bahwa pembelajaran perbankan syariah tidak berpengaruh, literasi keuangan syariah dan risk tolerance berpengaruh highly significant terhadap perilaku berinvestasi di Bank Syariah pada Mahasiswa Perguruan Tinggi Negeri di Surabaya, kemudian gender tidak dapat memoderasi pembelajaran perbankan syariah terhadap perilaku berinvestasi akan tetapi secara simultan Gender berpengaruh terhadap perilaku berinvestasi, gender dapat memoderasi literasi keuangan syariah secara weakly significant dan risk tolerance secara significant terhadap perilaku berinvestasi di Bank Syariah pada Mahasiswa Perguruan Tinggi Negeri di Surabaya.]
ANALISIS KESALAHAN BERBAHASA PADA SOAL UJIAN PELAJARAN BAHASA INDONESIA DI SMA
Authors: Wardani Shinta , Setiawan Budhi , Hastuti Sri 
Published: January 2022

<em>This research aims to describe and explain: (1) the kinds of mistakes-speaking on the matter, (2) the cause of the error on the question of language, (3) communication effects caused due to an error on a question of language Final Assessment subjects Indonesian Language grade XI public senior high school in Sukoharjo Area school, (4) understanding teacher against the rule drafting problem , and (5) precision drafting problem Final Assessment subjects Indonesian Language grade XI public senior high school in Sukoharjo based on rules of preparation of a matter. This type of research is qualitative research. Qualitative research this time is both a content analysis (content analysis) with the main data source about the Final Assessment of the Odd Semester subjects Indonesian Language grade XI public senior high school in Sukoharjo . The technique of sampling with purposive sampling and snowball sampling. This research uses data sources triangulation and triangulation method as a test of the validity of the data. The results of the analysis of the findings can be explained as follows. First, errors in language reserved assessment of the end of the Semester in the form of spelling errors, Word, and sentence. Second, language mistakes caused by internal factors and external factors. Internal factors in the form of less understand linguistic rules, the lack of rigour in drawing up the question, a habit of relying on a team of editing, and the wrong habits. While external factors in the form of the mistakes of other languages, is vulnerable for a short time, and there is no evaluation. Third, the effect of communication language errors are significant because the learners feel difficulty in understanding the intent of the question. Fourth, teachers less understand rule drafting reserved either in theory or practice. Fifth, the question of the drafting of the Rules contained in the matter of the assessment of the finalsemester subjects Indonesian Language grade XI public senior high school in Sukoharjo is not fully using the rules of preparation of the matter that is being applies both from the aspect of material and construction aspects.</em>
Green and Resilient Mixed Supply Chain Network Design to Reduce Environmental Impacts and Deal With Disruptions
Authors: Vali-Siar Mohammad Mahdi , Roghanian Emad 
Published: January 2022

Abstract
Disruption risks may halt or adversely affect supply chain operations and can lead to deviations in its objectives. One of the most important objectives of the supply chain which can be adversely affected by disruptions, is environmental objective. Therefore, considering supply chain resilience and environmental aspects simultaneously is of great importance. In this paper, the problem of designing a green and resilient mixed open and closed-loop supply chain network under operational and disruption risks has been studied. A bi-objective mixed integer linear programming model is proposed to formulate the problem. Some resilience strategies are applied to deal with disruption risks and enhance supply chain resilience. In order to overcome the complexity of the problem and solve the problems with medium and large sizes, a new meta-heuristic algorithm called multi-objective hybrid Ant-colony optimization and teaching and learning based optimization (ACO-TLBO) has been proposed and compared with two hybrid metaheuristics and the augmented ε-constraint method through various test problems. The outcomes showed that the ACO-TLBO algorithm is very efficient in obtaining high-quality Pareto solutions and is the best method among the proposed methods. Also, in order to show the applicability of the problem and validate the model and solution methods, a real case study in the tire industry has been presented and analyzed. The results of analyses demonstrate the high effectiveness of resilience strategies and the necessity of joint consideration of resilience and greenness in the supply chain design.
Trends and Effect of Marginalization on Diabetes Mellitus-Related Mortality in Mexico, 1990-2019
Authors: Gutiérrez-León Eduardo , Escamilla-Santiago Ricardo Antonio , Martínez-Amezcua Pablo , Bilal Usama , Lazo Mariana , Ogaz-González Rafael , López-Cervantes Malaquías 
Published: January 2022

Abstract
Globally, diabetes mellitus (DM) is one of the leading causes of mortality. However, this behavior may differ over time for countries given their intrinsic factors. The objective of the study is to characterize the trend and assess the potential effect of marginalization on DM mortality during 1990-2019 in Mexico. We analyzed death certificates where DM was listed as the underlying cause of death (N=1,907,173) and the extent to which DM mortality changes, were associated with marginalization from an age-period-cohort analysis. DM mortality has increased for Mexico in the 1990-2019 period, this change was faster in the first half of our study and slowed after 2004. The highest marginalization quintiles drove the changes in DM mortality trends during 1990-2019 in Mexico, with higher risk of dying in these quintiles with aging than the lowest. In the most recent cohorts, the highest marginalization quintiles showed twice the risk of dying from DM than the lowest. Renal complications were the leading cause of death in persons with DM during 1990-2019, with a marked increase since 1999-2001. In conclusion, Mexico continues with a very high DM mortality, but this has slowed over time, and subnational differences in the marginalization can partially explain this trend.
Coupled Modes Enhance Random Lasing in Plasmonic Thin Etalons
Authors: Haddawi S. F. , Roostaei N. , Hamidi S. M. 
Published: January 2022

Abstract
In this work, we experimentally and theoretically proved a flexible fine random laser from a two-face etalon plasmonic structure based on PDMS. Accordingly, PDMS was fabricated using the nanoimprint lithography method and coated by a thin gold layer with a thickness of 35 nm using a PVD device and light-emitting polymer (F8PT) to enhance the scattering and efficiency of the random laser. Using a plasmonic gold grating as a substrate, the simulation results compared the upside and downside of the plasmonic etalon structure. Moreover, an enhancement was observed in light transmission, and it is common to predict high efficiency in random lasing properties. The experimental results showed a comparison between normal plasmonic etalon samples and symmetric and asymmetric etalon-based nanostructures with thicknesses of 200, 400 and 600 \(\mu m\) and reported that random lasing properties had better results for samples with thinner spaces based on coupled mode effects. Correspondingly, this was done by increasing the intensity and decreasing the lasing threshold from 22 𝜇J in normal etalon to 16\(\mu J\) in the thinnest etalon structure.
Dynamic Changes of Peripheral Blood Markers Predict Prognosis of Patients with Advanced Non-Small Cell Lung Cancer Receiving Anti-PD-1/PD-L1 Treatment
Authors: Tang Gaoyan , Liu Yan , Zhang Qingyun , Yang Baohong , Ding Yanhong , Yu Guohua 
Published: January 2022

Abstract
Background Immune checkpoint inhibitors have been routinely used in the treatment of advanced non- small-cell lung cancer (aNSCLC) with significantly improved survival rate. However, the identification of reliable prognositic and predictive biomarkers is lacking. The aim of the study was to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and their dynamic changes for aNSCLC. Methods We retrospectively analyzed 60 patients with aNSCLC who received immunotherapy. The NLR and PLR were assessed at baseline (NLR0 and PLR0) and after 4 cycles of treatment (NLR4c and PLR4c). Results Of all aNSCLC patients on immunotherapy, 47 (78.3%) cases were in the response group. Whether at baseline or after 4 cycles of treatment, the levels of NLR and PLR in the response group were both significantly lower than those in the non-response group (p < 0.05). Patients with a high NLR4c had poor progression-free survival (PFS) and overall survival (OS) independently in multivariate analysis (3.90 vs. 7.50 months, p = 0.005; 7.20 vs. 15.90 months, p = 0.041, respectively). Patients with high NLR0-highNLR4c were associated with poor PFS and OS (p = 0.009, p = 0.001 respectively). Results are similar for PLR. Conclutions NLR after 4 cycles of treatment and dynamic changes of NLR and PLR during immunotherapy might help to predict a more accurate prognosis in aNSCLC patients.
Ceramic Workers and the Inflammatory Effects of the Silica Dust on the Nasal Mucosa Detected by Nasal Cytology: a Pilot Study
Authors: Begvarfaj Elona , Greco Emilio , Caruso Arturo Armone , Masieri Simonetta , Velardita Carmelita , Cavaliere Carlo 
Published: January 2022

Abstract
Background. Adverse health effects due to occupational exposures are a global public health concern and have been studied for many years. Ceramic workers are occupationally exposed to a wide range of toxic substances as they manage clay (silico-aluminous feldspar mixed with sodium, potassium salts and iron oxide). The objective of this study was to assess the presence of any inflammation or alteration of the nasal mucosa of ceramic workers by nasal cytology.Materials and methods. Ceramic workers from Caltagirone (Italy) were enrolled. Nasal symptoms, atopy, health habits and workplace features were assessed by a special questionnaire, and nasal mucosa health was evaluated by nasal cytology.Results. The cytological study of the nasal mucosa showed the constant presence of abundant, thick and filamentous mucus, as well as a reorganization of the nasal cellularity with a prevalence of muciparous metaplasia and almost total absence of hair cells, for almost all of the subjects.Conclusions. A significant proportion of ceramic workers showed chronic inflammatory rhinitis on nasal cytology, with a remodelling of the nasal mucosa and thick mucus. Nasal cytology may be a helpful tool for the screening of any pathology of the upper airways.
On Kinetic and Irreversible Thermodynamic Treatments of a Rarefied Gaseous Plasma Bounded by a Moving Plate.
Authors: Wahid Taha Zakaraia Abdel , Shahein Rabab 
Published: January 2022

Abstract
The peculiarities of the Rayleigh problem (RP) governing equations of a rarefied gaseous plasma (RGP) are analyzed. They were proven to conform to the entropic performance for the RGP system using the moment method, separation of variables, associated with traveling-wave techniques in irreversible thermodynamics (IT) approach. Maxwell’s equations and the Boltzmann equation (BE) of the Bhatnagar- Gross- Krook (BGK) type were solved. The BE considerable advantage is that it allows us to analyze the depth performance of the equilibrium electrons' velocity distribution function (EVDF) and the perturbed EVDF and their implementation to determine how far the system is from the equilibrium state (ES). As a result, the contrast between the equilibrium EVDF and the perturbed EVDF was conceptually elucidated at various periods. This significant benefit enables us to consider our model's non-equilibrium IT properties. For this purpose, the derived EVDF should be employed in entropy, production, and other critical thermodynamic variables. After analyzing the results, we discovered that H-theorem, thermodynamic principles, and Le Chatelier’s law were consistent with our model. The Gibbs rule was used to express how the various influences of the forces acting on the system's internal energy modification (IEM) are expressed. The findings showed that the proposed model could accurately capture the performance. The suggested type could accurately predict RGP helium and argon gases performance in the upper atmosphere's ionized belts. 3D-Graphics representing the physical parameters were generated using analysis of variance calculations, and the results are thoroughly presented. The importance of this research stemmed from its broad array of utilization in micro-electro-mechanical systems (MEMS), physics, electrical engineering, and nano-electro-mechanical systems (NEMS) technologies in a variety of commercial and industrial utilization.
Long-Term Association Between Intensive Medical Treatment and The Incidence of Cardiovascular Outcomes in Patients with Dyslipidemia: an Observational Study
Authors: Renke Guilherme , Moreira Annie , Pereira Marcela , Gapanowicz Débora , Mattos Fernanda , Ribeiro-Alves Marcelo 
Published: January 2022

Abstract
BackgroundThe management of patients with dyslipidaemia requires intensive medical follow-up as an essential part of treatment. We investigated the effect of intensive treatment on people with multiple risk factors for dyslipidaemia detected via screening. Here, we report the results of a retrospective 7-year follow-up analysis aimed at establishing whether differences in treatment and cardiovascular risk factors have been maintained and assessing their effects on cardiovascular outcomes.MethodsThis retrospective study involving 92 patients treated at the Lipid and Diabetes Service of the National Institute of Cardiology between January 1, 2012 and December 31, 2018. The patients were divided into two groups: the REG group, composed of 64 patients who had medical appointments from 2012 to 2018 (with the last appointment held between January 1 and December 31, 2018), and the DROP group, composed of 28 patients who had medical appointments in 2012 but did not complete regular appointments until 2018.ResultsIn evaluating the number of cardiovascular events by follow-up time between groups, we observed a total of 32 cases of myocardial infarction [CI 95% 0.08 (0.05-0.11)] in the studied population, with 26.6% in the REG group and 53.6% in the DROP group (p < 0.001). There was no statistically significant difference in the stroke and hospitalization between the two groups.ConclusionsThe analysis of cardiovascular outcomes in the studied population provides a greater understanding of the importance of intensive medical treatment, and there seems to be a benefit of a reduction in cardiovascular events, especially acute myocardial infarction, in patients who complete a greater number of medical appointments and receive multidisciplinary treatment on a regular basis.Trial registration: 31565920.3.0000.5272
Incidence, mortality and survival analysis of epithelial ovarian cancer in Brunei Darussalam
Authors: Leong Elvynna , Ong Sok King , Jali Fadzilah , Naing Lin 
Published: January 2022

Abstract
Background: This study provides population-based study of cancer incidence, mortality and survival rates for women diagnosed with epithelial ovarian cancer (EOC), and evaluate the prognostic factors of EOC patients survival in Brunei Darussalam.Methods: This is a retrospective study of patients diagnosed with EOC between 1st January 2007 and 31st December 2017 in Brunei Darussalam. Crude, age-specific, age-standardized incidence and mortality rates per 100,000 women were calculated. Kaplan-Meier method was used to determine the overall 5-years survival rate. Log-rank test was used to examine the differences in survival between groups. The multivariable Cox Proportional Hazard regression models were used to estimate the hazard ratio for overall survival and to identify the prognostic factors. Results: A total of 207 patients were included in the study. The crude incidence and mortality rates were 9.7 and 3.6 per 100,000 respectively while the age-standardized incidence and mortality rates were 11.3 (95% CI: 9.7,12.9) and 4.5 (95% CI: 3.4,5.6) per 100,000 respectively in the period 2007-2017. The overall mean age at diagnosis was 48.4 (standard deviation=15.3) years. The overall survival rates at 1, 3, and 5 years for EOC patients were 79.7%, 69.7%, and 61.4% respectively. Age at diagnosis, cancer stage, and histology were significant prognostic factors for patients’ survival. Older age at diagnosis (70 years vs <40 years), regional or advanced stage (vs localized stage) and having undifferentiated or other epithelial ovarian (vs serous carcinoma) were associated with having higher hazard of death. Conclusion: Early detection of disease should be emphasized through public education and raising awareness to improve survival rates of patients with EOC.