bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism and Prediction of Geothermal Resources Controlled by Neotectonics in Mountainous Areas: A Case Study of Southeastern Zhangjiakou City, China
Authors: Yuan Wenzhen , Lei Xiaodong , Liu Tongzhe , Wang Siqi , Xing Yifei , Zhu Ruijie , Yang Fengtian , Zhang Dailei , Gao Jun , Zhang Baojian 
Published: April 2022

The geothermal resources in mountainous areas are usually controlled by neotectonic faults. To minimize the risk in site selection for geothermal drilling, the controlling mechanism must be identified. Based on the neotectonic control theory for geothermal resources, the occurrence of the geothermal resources in the mountainous area in southeastern Zhangjiakou city was investigated. The investigation was divided into three stages. Firstly, field investigation for neotectonics was carried out to characterize the kinematics and the stress state of the faults, including fault occurrences, tectonic stages, and paleostress analysis, and in total 19 neotectonic faults were confirmed. Based on Riedel shear model and present stress field, their conductivity for geothermal water was inferred; secondly, geophysical and geochemical surveys were applied to identify the stress state and characterize the occurrence of the potential water conductive faults. The results showed that the combined use of magnetotelluric sounding (MT), controllable source audio magnetotelluric sounding (CSAMT), and 2D seismologic survey is effective in delineating fault occurrence, strata distribution, and water conductivity within 1,000 m depth, while measurement of 222Rn activity in soil gas across the neotectonic faults is effective to investigate the groundwater conductivity of the faults, and all the neotectonic faults in the study area striking clockwise from N5°E to N25°W are considered to be water conductive; thus, the areas at the intersection zones of neotectonic faults in the basin in groundwater runoff and discharge regions are promising targets for geothermal exploration. This conceptual model was verified by the geothermal fields already discovered in the study area and proved to be reasonable, and then a potential drilling site was predicted and proved to be successful. It is suggested that this workflow for geothermal exploration is suitable for Zhangjiakou city and may also be applied to other mountainous areas.
Effect of Hydrocarbon Presence and Properties on the Magnetic Signature of the Reservoir Sediments of the Catcher Area Development Region, UK North Sea
Authors: Abdulkarim Maryam A. , Muxworthy Adrian R. , Fraser Alastair , Sims Michael , Cowan Alison 
Published: April 2022

This paper presents a detailed study investigating the effect of hydrocarbon presence on magnetic mineral diagenesis in sediments from the Catcher Area Development (CAD) region, UK North Sea, between 1,000 and 1,500 m (True Vertical Depth Sub-Sea). Magnetic analysis of core samples from hydrocarbon fields of the region and nearby dry-well sandstones (background) was carried out to determine if their signatures can serve as a proxy for understanding petroleum reservoir systems. From the background samples, nanometric and micron-sized magnetite, hematite and titano-iron oxides, were identified. Hydrocarbon presence in the reservoir sediments was found to diminish the iron-oxide signature and favour the precipitation of hexagonal pyrrhotite, siderite and potentially vivianite, lepidocrocite, greigite and paramagnetic iron sulphides. Hexagonal pyrrhotite was found at the oil-water transition zones. This relationship is possibly related to biodegradation at this interface. Siderite was found in increased abundance at shallower depths within the reservoir, which we attribute to hydrocarbon vertical migration and biodegradation. The interbedded shales also experienced significant magnetic mineral diagenesis that depended on its proximity to the hydrocarbon plume. These findings suggest that mineral magnetism can be applied to the identification of oil-water transition zones, reserve estimation, production planning and the determination of hydrocarbon migration pathways. It also suggests that mineral magnetic methods can be used to estimate the timing of hydrocarbon migration.
Research on Unsteady Wake Characteristics of the NREL 5MW Wind Turbine Under Yaw Conditions Based on a LBM-LES Method
Authors: Xue Feifei , Xu Chang , Huang Haiqin , Shen Wenzhong , Han Xingxing , Jiao Zhixiong 
Published: April 2022

The yaw of a large-scale wind turbine will change the aerodynamic performance of its substructures. In view of this, this article applied a LBM-LES method to numerically simulate the yawed MEXICO wind turbine and compared the numerical results with the experimental data collected in the New MEXICO experiment to verify the reliability of the method. A rapid dynamic yaw is defined with a yaw speed of 5°/s in yaw control, while a slow dynamic yaw is with a yaw speed of 0.3°/s. The NREL 5 MW offshore wind turbine was used to explore the constant wake characteristics under the conditions of a rapid dynamic yaw and of a slow dynamic yaw. It can be seen from the results that the LBM-LES method captures the detailed characteristics of the complex unsteady flow field of the wind turbine. In the rapid dynamic yaw process, the transition area between the far wake and the near wake shows a large deflection. However, in the process of the slow dynamic yaw, the far wake deflects forward relatively to the yaw. The dynamic yaw wake forms a kidney-shaped cross-section similar to the one in a steady yaw. The yaw wake recovers faster than the wake without yaw, and the rapid dynamic yaw wake has an asymmetric structure. The thrust of the wind turbine drops rapidly during the rapid dynamic yaw, while the thrust of the slow dynamic yaw decreases gradually. The thrust drops three times per rotor revolution, and the time of thrust decrease is delayed as the yaw angle increases.
Explorations Into the Viability of High Voltage Bipolar Na-Ion Cells Using Liquid Electrolytes
Authors: Rudola Ashish , Wright Christopher J. , Barker Jerry 
Published: April 2022

Bipolar electrodes can be defined as electrodes where cathode and anode active materials exist on either side of a shared current collector substrate. The resultant rechargeable bipolar batteries, using series-connected electrochemical cells within one sealed enclosure, can enable high-voltage systems irrespective of the voltage of the cathode//anode couple used. The sodium-ion battery, being well-suited for the bipolar concept, is now rapidly being commercialized and has higher energy densities than most rechargeable battery technologies. However, bipolar sodium-ion batteries using commercially-feasible liquid electrolytes and manufacturing methodologies, have not been demonstrated at scale yet. Herein, we explore the design methodology needed to enable commercial realization of such bipolar sodium-ion batteries, using liquid electrolytes and different types of cathode//anode couples. We show good cycling stabilities over 200 cycles and potential for voltages beyond 6 V for bipolar Na-ion pouch cells. We also introduce a scalable method to fabricate nSmP Na-ion/mixed-chemistry bipolar cells (n cells in series; m cells in parallel) in a single, sealed cell. Our results point to realistic promise for high voltage and sustainable bipolar sodium-ion batteries.
EASIX and Severe Endothelial Complications After CD19-Directed CAR-T Cell Therapy—A Cohort Study
Authors: Korell Felix , Penack Olaf , Mattie Mike , Schreck Nicholas , Benner Axel , Krzykalla Julia , Wang Zixing , Schmitt Michael , Bullinger Lars , Müller-Tidow Carsten , Dreger Peter , Luft Thomas 
Published: April 2022

BackgroundEndothelial dysfunction is associated with two main complications of chimeric antigen receptor T (CAR-T) cell therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). This study evaluates the Endothelial Activation and Stress Index (EASIX) as a prognostic marker for high-grade CRS and ICANS in patients treated with CD19-directed CAR-T cells.MethodsIn this retrospective study, a training cohort of 93 patients from the ZUMA-1 trial and a validation cohort of 121 patients from two independent centers (University Hospital Heidelberg, Charité University Medicine Berlin) were investigated. The primary objective was to assess the predictive capacity of EASIX measured immediately before the start of lymphodepletion (EASIX-pre) for the occurrence of grade ≥3 CRS and/or ICANS. To explore a possible endothelial link, serum levels of endothelial stress markers (angiopoietin-2, suppressor of tumorigenicity-2, soluble thrombomodulin, and interleukin-8) were determined before lymphodepletion and on day 7 after CART infusion in the validation cohort (n = 47).ResultsThe prognostic effect of EASIX-pre on grade ≥3 CRS and/or ICANS was significant in the training cohort [OR 2-fold increase 1.72 (1.26–2.46)] and validated in the independent cohort. An EASIX-pre cutoff &gt;4.67 derived from the training cohort associated with a 4.3-fold increased odds ratio of severe CRS/ICANS in the independent cohort. Serum endothelial distress markers measured on day+7 correlated with EASIX-pre and associated with severe complications.ConclusionsEASIX-pre is a powerful predictor of severe CRS/ICANS after CD19-directed CART therapy and might be used as a basis for risk-adapted prevention strategies.
Effect of Calcium Sulphate Pre-crosslinking on Rheological Parameters of Alginate Based Bio-Inks and on Human Corneal Stromal Fibroblast Survival in 3D Bio-Printed Constructs
Authors: Kostenko Anastassia , Swioklo Stephen , Connon Che J. 
Published: April 2022

The principle of three-dimensional (3D) bio-printing involves integration of biomaterials, live cells and controlled motor systems for creating complex biomimetic constructs. Bio-ink is one of the most important components in the process of 3D bio-printing and needs to be sufficiently viscous to be dispensed as a free-standing filament but be biocompatible to maintain cell viability and function. Alginate has been used widely for 3D bio-printing due to its biocompatibility, tunable properties, rapid gelation, low cost, and ability to be functionalized to direct cell behavior. By tuning the physiochemical parameters of alginate-based bio-inks, such as viscosity, improvements in print resolution, fidelity and growth characteristics of encapsulated cells can be achieved. This study aimed to improve the printability of low concentration alginate bio-inks by utilizing calcium sulphate (CaSO4) pre-crosslinking. A variety of alginates, differing in their viscosity, molecular weight and b-D-mannuronate and α-L-guluronate residues were investigated by wet spinning and bio-printing. Rheological and structural properties of pre-crosslinked alginates were characterized with the aim of mitigating the resolution problems associated with the use of low percentage alginate bio-inks, more favorable for maintaining cell viability. Pre-crosslinking produced a significant effect on viscosity of biomaterials improving their suitability for the bio-printing process and influencing the final resolution of the printed structure. Medium viscosity high b-D-mannuronate containing alginate (MVM) showed the highest degree of viscosity change compared to the control (p &lt; 0.0001; n = 6), assessed by single value viscometry analysis and shear rheology, after pre-crosslinking and was subsequently used in experiments with cells. The survival of human corneal stromal fibroblasts (CSFs) was assessed using CellTiterGlo metabolic assay and confirmed with Calcein acetoxymethyl and Ethidium homodimer -1 live/dead staining in pre-crosslinked alginate fibers and bio-printed lattices. Encapsulation of CSFs in pre-crosslinked alginate-based bio-inks did not have a detrimental effect on CSF viability compared to the non-pre-crosslinked control over 7 days under standard cell culture conditions (p &gt; 0.05, n = 3). Overall, printability of low percentage alginate bio-inks was improved by pre-crosslinking without affecting the biocompatibility of the bio-inks.
Development and Validation of a Prognostic Nomogram for Prognosis in Patients With Renal Artery Stenosis
Authors: Li Yan , Ma Na , Zhang Yuewei , Wang Siyu , Sun Youjing , Li Mengpu , Ai Hu , Zhu Hui , Wang Yang , Li Peng , Guo Fajin , Li Yongjun , Ren Junhong 
Published: April 2022

Background and ObjectiveRenal artery stenosis (RAS) is associated with an increased risk of renal function deterioration (RFD). Our previous study showed that renal cortical blood perfusion assessed by contrast-enhanced ultrasound (CEUS) was an important related factor for RFD in RAS patients. Based on several conventional related factors confirmed by previous studies, we aimed to establish and verify a CEUS+ scoring system to evaluate the risk of RFD at 1 year of follow-up in RAS patients.MethodsThis study was a single-center retrospective study. A total of 497 elderly RAS patients (247 in the training group and 250 in the verification group) admitted to the Beijing Hospital from January 2016 to December 2019 were included. The baseline characteristics of the patients on admission (including general conditions, previous medical history, blood pressure, blood creatinine, RAS, and cortical blood perfusion in the affected kidney) and renal function [glomerular filtration rate (GFR)] at 1-year of follow-up were collected. We used the univariate and multivariate logistic regressions to establish a CEUS+ scoring system model, the receiver operating characteristic (ROC) curve and area under the curve (AUC) to evaluate prediction accuracy, and the decision curve analysis and nomogram to evaluate the clinical application value of CEUS+ scoring system model.ResultsAmong the 497 patients enrolled, 266 (53.5%) were men, with an average age of (51.7 ± 19.3) years. The baseline clinical-radiomic data of the training group and the verification group were similar (all p &gt; 0.05). Multivariate logistic regression analysis results showed that age [Odds ratio (OR) = 1.937, 95% confidence interval (CI): 1.104–3.397), diabetes (OR = 1.402, 95% CI: 1.015–1.938), blood pressure (OR = 1.575, 95% CI: 1.138–2.182), RAS (OR = 1.771, 95% CI: 1.114–2.816), and area under ascending curve (AUCi) (OR = 2.131, 95% CI: 1.263–3.596) were related factors for the renal function deterioration after 1 year of follow-up (all p &lt; 0.05). The AUC of the ROC curve of the CEUS+ scoring system model of the training group was 0.801, and the Youden index was 0.725 (specificity 0.768, sensitivity 0.813); the AUC of the ROC curve of the validation group was 0.853, Youden index was 0.718 (specificity 0.693, sensitivity 0.835). There was no significant difference in ROC curves between the two groups (D = 1.338, p = 0.325). In addition, the calibration charts of the training and verification groups showed that the calibration curve of the CEUS+ scoring system was close to the standard curve (p = 0.701, p = 0.823, both p &gt; 0.10).ConclusionThe CEUS+ scoring system model is helpful in predicting the risk of worsening renal function in elderly RAS patients.
The Research Landscape of Multiple Endocrine Neoplasia Type 1 (2000–2021): A Bibliometric Analysis
Authors: Feng Chenzhe , Chen Haolin , Huang Leyi , Feng Yeqian , Chang Shi 
Published: April 2022

IntroductionThis study aimed to investigate the landscape of Multiple Endocrine Neoplasia Type 1 research during the last 22 years using machine learning and text analysis.MethodIn December 2021, all publications indexed under the MeSH term “Multiple Endocrine Neoplasia Type 1” were obtained from PubMed. The whole set of search results was downloaded in XML format, and metadata such as title, abstract, keywords, mesh words, and year of publication were extracted from the original XML files for bibliometric evaluation. The Latent Dirichlet allocation (LDA) topic modeling method was used to analyze specific themes.ResultsThis study eventually contained 1,407 publications. Among them, there are 768 (54.58%) case reports and reviews. Text analysis based on MeSH words revealed that the most often studied clinical areas include therapy efficacy, prognosis, and genetic diagnosis. The majority of basic study is focused on genetic alterations. The LDA topic model further identifies three topic clusters include basic research, treatment cluster, and diagnosis cluster. In the basic research cluster, many studies are focused on the expression of Menin. The primary focus of the therapy cluster is pancreatic resections and parathyroidectomy. In the diagnose cluster, the main focus is on Genetic Diagnosis and screening strategies for Hereditary Cancer Syndrome.ConclusionThe current state of research on MEN1 is far from adequate. Research on rare diseases MEN1 necessitates implementing a broad research program involving multiple centers to advance MEN1 research together.
QuantiFERON-TB Gold Plus Assay in Patients With Latent vs. Active Tuberculosis in a Low Incidence Setting: Level of IFN-γ, CD4/CD8 Responses, and Release of IL-2, IP-10, and MIG
Authors: Carrère-Kremer Séverine , Kolia-Diafouka Pratt , Pisoni Amandine , Bolloré Karine , Peries Marianne , Godreuil Sylvain , Bourdin Arnaud , Van de Perre Philippe , Tuaillon Edouard 
Published: April 2022

ObjectivesWe analyzed the results of the QuantiFERON Glod Plus assay (QFT) and cytokine patterns associated with active tuberculosis (ATB) among patients with positive QFT.MethodsA total of 195 patients are QFT-positive, among which 24 had an ATB and 171 had a latent tuberculosis infection (LTBI). Interferon-gamma (IFN-γ) secretion was analyzed relative to interleukin-2 (IL-2), IFN-γ inducible protein or CXCL-10 (IP-10), and monokine induced by IFN-γ or CXCL-9 (MIG) secretion, and then compared between two sets of peptide antigens [tube 1 - cluster of differentiation 4 (CD4+) T cell stimulation; tube 2 - CD4+/CD8+ T cell response].ResultsHigher IFN-γ responses were measured in the ATB group (p = 0.0089). The results showed that there was a lower ratio of tube 1/tube 2 IFN-γ concentrations in the ATB group (p = 0.0009), and a median [interquartile ranges (IQR)] difference between the two sets at −0.82 IU/ml (−1.67 to 0.18) vs. −0.07 IU/ml (−0.035 to 0.11, p &lt; 0.0001) in the ATB group compared to the LTBI group, respectively. In addition, patients with low ratios of IL-2/IFN-γ, IP-10/IFN-γ, and MIG/IFN-γ were much more likely to have ATB.ConclusionHigh levels of IFN-γ secretion, preferential IFN-γ response in tube 2, and lower secretion of IL-2, IP-10, and MIG release relative to IFN-γ secretion were more likely observed in subjects with ATB. These features of T cell response may be helpful in low prevalence settings to suspect ATB in patients tested positive for IFN-γ release assays (IGRA).
The Attenuation Value Within the Non-hypodense Region on Non-contrast Computed Tomography of Spontaneous Cerebral Hemorrhage: A Long-Neglected Predictor of Hematoma Expansion
Authors: Chen Yong , Cao Dan , Guo Zheng-Qian , Ma Xiao-Ling , Ou Yi-Bo , He Yue , Chen Xu , Chen Jian 
Published: April 2022

Background and PurposeThe ability of attenuation value of the non-hypodense region of hematoma in non-contrast computed tomography (NCCT) for predicting hematoma expansion (HE) remains unclear. Our purpose is to explore this relationship.MethodsTwo cohorts of patients were collected for analysis. The region where we measured hematoma attenuation values was limited to the non-hypodense region that was not adjacent to the normal brain tissue on NCCT. The critical attenuation value was derived via receiver operating characteristic (ROC) curve analysis in the derivation cohort and its predictive ability was validated in the validation cohort. Independent relationships between predictors, such as critical attenuation value of the non-hypodense region and HE were analyzed using the least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic analysis.ResultsThe results showed that the attenuation value &lt;64 Hounsfield units (HU) was independently associated with HE [odds ratio (OR), 4.118; 95% confidential interval (CI), 1.897–9.129, p &lt; 0.001] and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and area under the curve (AUC) for predicting HE were 36.11%, 81.71%, 1.97, 0.78, 44.8%, 75.7%, and 0.589, respectively.ConclusionsOur research explored and validated the relationship between the attenuation value of the non-hypodense region of hematoma and HE. The attenuation value &lt; 64 HU was an appropriate indicator of early HE.
Control of Vascular Risk Factors and Response to Stroke Symptoms in Argentina During the COVID-19 Quarantine. The SIFHON-COVID Population Survey
Authors: Rodríguez Pérez María S. , Rosales Julieta S. , Dossi Daiana E. , Ameriso Sebastián F. 
Published: April 2022

Background and ObjectivesIn preparation for the suspected influx of COVID-19 patients, many healthcare systems reduced or discontinued provision of “non-urgent” care. This decision had potential impact on stroke prevention and management. We conducted a large population survey to assess the effect of mandatory social isolation on routine health controls, emergency consultations and other stroke care-related behaviors of the population during the pandemic.MethodsWe distributed multiple-choice anonymous questionnaires through the institutional email database and through the email database of clients of a beverage delivery company. Most respondents resided in the metropolitan area of Buenos Aires. This is the area where the infection rates were highest and restriction measures were hardest. The survey assessed demographic characteristics and actual and potential behaviors of people regarding medical checkups, risk factors control, medication provision and response to onset of symptoms consistent with stroke or TIA. Surveys were sent during May 2020, the strictest period of the quarantine in Argentina.ResultsA total of 10,303 questionnaires were completed. Thirty-seven percent of the respondents were older than 60 years, 74% were women and 16% lived alone. Vascular risk factors were present in 39% of the individuals. Seventy-six percent did not continue with their regular medical checkups during the mandatory social and preventive isolation, 21% had difficulty obtaining medical prescriptions and only 38% considered that health institutions had implemented reliable safety measures to avoid exposure to COVID-19. When asked about response in case of onset of stroke symptoms, 9% would not consult given the context of the pandemic. Six percent reported having had symptoms consistent with stroke or TIA but only 35% went to a hospital. The vast majority of the respondents said they were awaiting for the end of the quarantine to resume their usual medical care.ConclusionsThe implementation of a quarantine may have some serious adverse effects on the prevention, diagnosis and treatment of stroke. These undesirable aspects should be taken into consideration in the planning, communication and implementation of health policies.