bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-sensitive prognostic performance of an afterload-integrated diastolic index in heart failure with preserved ejection fraction: a prospective multicentre observational study
Authors: Hoshida Shiro , Hikoso Shungo , Shinoda Yukinori , Tachibana Koichi , Minamisaka Tomoko , Tamaki Shunsuke , Yano Masamichi , Hayashi Takaharu , Nakagawa Akito , Nakagawa Yusuke , Yamada Takahisa , Yasumura Yoshio , Nakatani Daisaku , Sakata Yasushi 
Published: August 2022

ObjectivesThe prognostic significance of an afterload-integrated diastolic index, the ratio of diastolic elastance (Ed) to arterial elastance (Ea) (Ed/Ea=[E/e′]/[0.9×systolic blood pressure]), is valid for 1 year after discharge in older patients with heart failure with preserved ejection fraction (HFpEF). We aimed to clarify the association with changes in Ed/Ea from enrolment to 1 year and prognosis thereafter in patients with HFpEF.SettingA prospective, multicentre observational registry of collaborating hospitals in Osaka, Japan.ParticipantsWe enrolled 659 patients with HFpEF hospitalised for acute decompensated heart failure (men/women: 296/363). Blood tests and transthoracic echocardiography were performed before discharge and at 1 year after.Primary outcome measuresAll-cause mortality and/or re-admission for heart failure were evaluated after discharge.ResultsHigh Ed/Ea assessed before discharge was a significant prognostic factor during the first, but not the second, year after discharge in all-cause mortality or all-cause mortality and/or re-admission for heart failure. When re-analysis was performed using the value of Ed/Ea at 1 year after discharge, high Ed/Ea was significant for the prognosis during the second year for both end points (p=0.012 and p=0.033, respectively). The poorest mortality during 1‒2 years after enrolment was observed in those who showed a worsening Ed/Ea during the first year associated with larger left ventricular mass index and reduced left ventricular ejection fraction. In all-cause mortality and/or re-admission for heart failure, the event rate during 1‒2 years was highest in those with persistently high Ed/Ea even after 1 year.ConclusionsTime-sensitive prognostic performance of Ed/Ea, an afterload-integrated diastolic index, was observed in older patients with HFpEF.Trial registration numberUMIN000021831.
Financial interventions for family caregivers of individuals with chronic illness: a scoping review protocol
Authors: Thomas Hebdon Megan C , Phan Cuong Thi Thanh , Phillips Carolyn , Wan Shaowei , Doyon Katherine , Gray Tamryn , Johnson Lee Ann , Pottepalli Vyshnavi , Fischer Stacy 
Published: August 2022

IntroductionThere are 53 million caregivers in the USA providing informal care for individuals with chronic illnesses. These caregivers contribute significantly to the healthcare system, yet they may experience adverse consequences due to caregiving, including financial burden. The purpose of this scoping review is to fill a research gap on understanding the nature and effect of financial interventions for family caregivers.Methods and analysisThis study will use the Arksey and O’Malley scoping review framework to systematically search for articles in MEDLINE, PubMed, CINAHL Complete, Cochrane Library, PsycINFO, Dissertations & Theses Global, and Web of Science during April 2022. Articles published from 1997 to the present will be included for the review. Data from articles will be extracted and summarised for financial intervention nature, scope, measurement, effect and health system context.Ethics and disseminationThis study does not include human subjects; therefore, no ethical review will be undertaken. Findings will be disseminated in scholarly journals and at caregiving and ageing conferences, such as the Gerontological Society of America.
Aspects of non-interacting and interacting universe: a complete scenario
Authors: Raushan Rakesh , Shukla A.K. , Chaubey R. 
Published: August 2022

The evolution of the dark energy within the scope of a spatially homogeneous and isotropic Friedmann–Robertson–Walker model filled with barotropic fluid and dark energy is examined. We have considered the two cases of an interacting and non-interacting two-fluid (barotropic and dark energy) scenario and obtained the exact solutions to the corresponding field equations. In an interacting model, we have considered linear as well as quadratic interaction between dark sectors of the universe. We have also given the quadrature form for general interaction coupling parameter via Q = αρ m n, n ⩾ 1 and discussed the evolution of energy densities and effective equation of state with cosmic time for flat, closed, and open universes. It is also examined that the matter energy density is dominated in early phase of the universe, whereas the dark energy density is dominated in later phase of the universe for both scenarios, which is in concurrence with current observations.
Renormalizable standard model extension with S4 symmetry for neutrino mass and mixing
Authors: Vien V.V. 
Published: August 2022

We suggest a renormalizable standard model extension based on S4 symmetry that accommodates the recent observed neutrino oscillation pattern. Through the type-I seesaw mechanism, the smallness of the active neutrino mass and its hierarchy are produced. The model generates the updated data on neutrino parameters in which the reactor neutrino mixing angle θ13, the atmospheric neutrino mixing θ23, and the Dirac phase δ for both NH and IH belong to 1σ range, while the solar mixing angle θ12 = 35.70° belongs to 2σ range. The effective masses are found to be 〈 mee〉 = 5.74 meV for NH and 〈 mee〉 = 48.1 meV for IH within their allowed constraints.
Existence of energy density homogeneity for radiating spheres in f ( G , T ) gravity
Authors: Yousaf Z. , Bhatti M. Z. , Farhat A. 
Published: August 2022

This work discusses the responsible quantities of the emergence inhomogeneity by taking locally anisotropic radiating fluid in [Formula: see text] theory, where T and [Formula: see text] indicate the trace of stress energy tensor and Gauss–Bonnet terms. The temporal and radial change in mass function is observed with the help of a modified version of Einstein’s field equations. To observe the dynamics of self-gravitating fluid, the dynamical equations and differential equations for conformal tensor are constructed, which help to understand the role of correction terms, Weyl curvature, and fluid parameter in the energy–density irregularity. Various forms of fluid are addressed to meet the desired results.
Addendum to: Dynamical torsion suppression in Brans–Dicke inflation and Lorentz violation (Eur Phys J C (2022)): Einstein–Cartan–Brans–Dicke–Maxwell universe with a chiral dynamo?
Authors: de Andrade L. C. Garcia 
Published: August 2022

AbstractWe have recently shown that in Einstein–Cartan–Brans–Dicke (ECBD) gravity, torsion effects are not present in today’s universe because they are suppressed in a four-dimensional system, as in the bulk of five-dimensional braneworld endowed with torsion. In this addendum, we naturally introduce new features on the ECBD Maxwell Lagrangian dynamics deriving the chiral dynamo equation, and studying its physical properties. Magnetogenesis results are derived in this ECBDM universe. In particular we show, in the present universe, torsional magnetic fields of the second-order in the ohmic resistivity behave as $$B_{{\text {ECBD}}}=10^{-13}$$

B
ECBD

=

10

-
13

Gauss, which is exactly the estimate made by Miniati et al. (Phys Rev Lett, 2018) for the axion QCD magnetic field in the present universe. We found this at 1pc coherent length, whereas they found it at 20pc. To obtain this result, we consider a strong magnetic field of the order of the Biermann battery $$10^{30}G$$

10
30

G

. This seems to show that our model of ECBDM gravity can be used with success in inflationary magnetogenesis with torsion. Inflation or deflation are shown to depend upon torsion chirality. Torsion is shown to depend upon the BD parameter $${\omega }$$
ω
and decays in time as in the reference to which this addendum refers (Garcia de Andrade in Eur Phys J C, 2002).
A radiatively induced inverse seesaw model with hidden U(1) gauge symmetry
Authors: Nomura Takaaki , Okada Hiroshi , Sanyal Prasenjit 
Published: August 2022

AbstractWe propose an inverse seesaw scenario under hidden U(1) gauge symmetry, having rather natural hierarchies among neutral fermion mass scales. The hierarchies are derived from theory and experimental constraints. The theory requires Majorana exotic masses have to be induced at one-loop level. The experimental side requests that the Dirac mass terms has to be highly suppressed to satisfy the constraints from the lepton flavor violations (LFVs) such as $$\mu \rightarrow e\gamma $$

μ
→
e
γ

. In order to induce such a small Majorana exotic masses we introduce exotic fermions and bosons that also provide us additional intriguing phenomenologies such as muon anomalous magnetic moment, dark matter candidate as well as LFVs and deviations in leptonic Z decays. We analyze these phenomenologies including neutrino oscillation data numerically, and show allowed region. Finally, we discuss the DM candidate in both the cases of fermion and scalar boson, where we focus on rather lighter range that is equal or less than 10 GeV. The dominant contributions originate from interactions of hidden gauge sector, and we show allowed ranges for both cases.
Gradual System F
Authors: Labrada Elizabeth , Toro Matías , Tanter Éric 
Published: August 2022

Bringing the benefits of gradual typing to a language with parametric polymorphism like System F, while preserving relational parametricity, has proven extremely challenging: first attempts were formulated a decade ago, and several designs have been recently proposed, with varying syntax, behavior, and properties. Starting from a detailed review of the challenges and tensions that affect the design of gradual parametric languages, this work presents an extensive account of the semantics and metatheory of GSF, a gradual counterpart of System F. In doing so, we also report on the extent to which the Abstracting Gradual Typing methodology can help us derive such a language. Among gradual parametric languages that follow the syntax of System F, GSF achieves a unique combination of properties. We clearly establish the benefits and limitations of the language, and discuss several extensions of GSF towards a practical programming language.
Exploring the Preventive and Restorative Functions of Lactobacillus pentosus in Flesh Deterioration Caused by Oxidized Fish Oil Diets in Hybrid Grouper (♀ Epinephelus fuscoguttatus
×
♂ E. lanceolatu)
Authors: Yan Xiaobo , Li Tao , Liu Hao , Li Zhihao , Tan Beiping , Pan Simiao , Huang Weibin , Suo Xiangxiang , Yang Yuanzhi , Dong Xiaohui 
Published: August 2022

The purpose was to investigate the preventive and restorative functions of Lactobacillus pentosus of hybrid grouper (♀ Epinephelus fuscoguttatus×♂ E. lanceolatu) flesh due to ingestion oxidized fish oil (OFO) diet. Basal diets were formulated using OFO as main lipid source and

1.0
×

10

9

CFU/g of L. pentosus was added to basal diet as experimental diet. Control group (OFO: 60 d basal diet), prevention group (OFOP:

30

d

experimental

diet
+
30

d

basal

diet

), and restoration group (OFOR:

30

d

basal

diet
+
30

d

experimental

diet

) were set up for grouper experiment with triplication. The results show that compared with the OFO group, the OFOP and OFOR groups significantly decreased muscle lipid deposition and lipid peroxidation production. The OFOP and OFOR groups significantly increased the polyunsaturated fatty acid content furthermore to improve nutritional value of muscle compared to the OFO group. Intervention with L. pentosus significantly influenced muscle flavor. OFOP and OFOR groups significantly upregulated expression of partial growth factor-related genes while downregulating expression of antioxidant-related genes. Consequently, the intervention of L. pentosus decreased lipid deposition and improved the nutritional value and flavor of grouper muscle, and it was recommended as a probiotic to prevent the deterioration of aquatic product quality.
Cardiac Structure and Function Across the Spectrum of Aldosteronism: the Atherosclerosis Risk in Communities Study
Authors: Brown Jenifer M. , Wijkman Magnus O. , Claggett Brian L. , Shah Amil M. , Ballantyne Christie M. , Coresh Josef , Grams Morgan E. , Wang Zhiying , Yu Bing , Boerwinkle Eric , Vaidya Anand , Solomon Scott D. 
Published: August 2022

Background:
Aldosterone production and mineralocorticoid receptor activation are implicated in myocardial fibrosis and cardiovascular events.

Methods:
Cardiac structure and function were assessed in 4547 participants without prevalent heart failure (HF) in the ARIC study (Atherosclerosis Risk in Communities), with echocardiography, aldosterone, and plasma renin activity measurement (2011–2013). Subjects were characterized by plasma renin activity as suppressed (≤0.5 ng/mL per hour) or unsuppressed (>0.5 ng/mL per hour). Cross-sectional relationships with cardiac structure and function, and longitudinal relationships with outcomes (HF hospitalization; HF and all-cause death; HF, death, myocardial infarction, and stroke; and incident atrial fibrillation) were assessed. Models were adjusted for demographic and anthropometric characteristics and additively, for blood pressure and antihypertensives.

Results:

Evidence of primary aldosteronism physiology was prevalent (11.6% with positive screen) and associated with echocardiographic parameters. Renin suppression was associated with greater left ventricular mass, left ventricular volumes, and left atrial volume index, and a lower E/A ratio (adjusted
P
<0.001 for all). Higher aldosterone was associated with greater left ventricular mass and lower global longitudinal strain and lateral E′. The highest tertile of aldosterone was associated with a hazard ratio of 1.37 (95% CI, 1.06–1.77; 5.5-year follow-up) for incident atrial fibrillation relative to the lowest. Renin suppression was associated with HF (hazard ratio, 1.34 [95% CI, 1.05–1.72]; 7.3-year follow-up), although these relationships did not remain statistically significant after additional adjustment for hypertension.

Conclusions:
Renin suppression and aldosterone excess, consistent with primary aldosteronism pathophysiology, were associated with cardiac structural and functional alterations and may represent an early target for mitigation of fibrosis with mineralocorticoid receptor antagonists.
Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication
Authors: Hussain Sultana Monira , Ernst Michael E. , Barker Anna L. , Margolis Karen L. , Reid Christopher M. , Neumann Johannes T. , Tonkin Andrew M. , Phuong Thao Le Thi , Beilin Lawrence J , Pham Thao , Chowdhury Enayet K. , Cicuttini Flavia M. , Gilmartin-Thomas Julia F.M. , Carr Prudence R. , McNeil John J. 
Published: August 2022

Background:
Impaired cerebral blood flow has been associated with an increased risk of falls. Mean arterial pressure (MAP) and variability in MAP have been reported to affect cerebral blood flow but their relationships to the risk of falls have not previously been reported.

Methods:
Utilising data from the Aspirin in Reducing Events in the Elderly trial participants, we estimated MAP and variability in MAP, defined as within-individual SD of MAP from baseline and first 2 annual visits. The relationship with MAP was studied in 16 703 participants amongst whom 1539 falls were recorded over 7.3 years. Variability in MAP was studied in 14 818 of these participants who experienced 974 falls over 4.1 years. Falls were confined to those involving hospital presentation. Cox regression was used to calculate hazard ratio and 95% CI for associations with falls.

Results:
Long-term variability in MAP was not associated with falls except amongst frail or prefrail participants using antihypertensive medications. Within this group each 5 mm Hg increase in long-term variability in MAP increased the risk of falls by 16% (hazard ratio, 1.16 [95% CI, 1.02–1.33]). Amongst the antihypertensive drugs studied, beta-blocker monotherapy (hazard ratio, 1.93 [95% CI, 1.17–3.18]) was associated with an increased risk of falls compared with calcium channel blockers.

Conclusions:
Higher levels of long-term variability in MAP increase the risk of serious falls in older frail and prefrail individuals taking antihypertensive medications. The observation that the relationship was limited to frail and prefrail individuals might explain some of the variability of previous studies linking blood pressure indices and falls.
Risk of Dementia Associated With Atrial Cardiopathy: The ARIC Study
Authors: Johansen Michelle C. , Wang Wendy , Zhang Michael , Knopman David S. , Ndumele Chiadi , Mosley Thomas H. , Selvin Elizabeth , Shah Amil M. , Solomon Scott D. , Gottesman Rebecca F. , Chen Lin Yee 
Published: August 2022

Background
The contribution of atrial cardiopathy to dementia risk is uncharacterized. We aimed to evaluate the association of atrial cardiopathy with incident dementia and potential mediation by atrial fibrillation (AF) and stroke.

Methods and Results

We conducted a prospective cohort analysis of participants in the ARIC (Atherosclerosis Risk in Communities) study attending visit 5 (2011–2013). We used Cox regression to determine the association between atrial cardiopathy and risk of dementia. Structural equation modeling methods were used to determine potential mediation by AF and/or stroke. Atrial cardiopathy was defined if ≥1 of the following at visit 5: P‐wave terminal force >5000 mV·ms in ECG lead V1, NT‐proBNP (N‐terminal pro–brain natriuretic peptide) >250 pg/mL or left atrial volume index ≥34 mL/m
2
by transthoracic echocardiography. We repeated our analysis necessitating ≥2 markers to define atrial cardiopathy. The prevalence of atrial cardiopathy was 34% in the 5078 participants (mean age 75 years, 59% female, 21% Black adults), with 763 participants developing dementia. Atrial cardiopathy was significantly associated with dementia (adjusted HR, 1.35 [95% CI, 1.16–1.58]), with strengthening of the effect estimate when necessitating ≥2 biomarkers (adjusted HR, 1.54 [95% CI, 1.25–1.89]). There was an increased risk of dementia among those with atrial cardiopathy when excluding those with AF (adjusted HR, 1.31 [95% CI, 1.12–1.55]) or stroke (adjusted HR, 1.28 [95% CI, 1.09–1.52]). The proportion of the effect mediated by AF was 4% (
P
=0.005), and 9% was mediated by stroke (
P
=0.048).

Conclusions
Atrial cardiopathy was significantly associated with an increased risk of dementia, with only a small percent mediation of the effect by AF or stroke.
COKG-QA: Multi-hop Question Answering over COVID-19 Knowledge
Graphs
Authors: Du Huifang , Le Zhongwen , Wang Haofen , Chen Yunwen , Yu Jing 
Published: August 2022

Abstract
COVID-19 evolves rapidly and an enormous number of people worldwide desire instant access to COVID-19 information such as the overview, clinic knowledge, vaccine, prevention measures, and COVID-19 mutation. Question answering (QA) has become the mainstream interaction way for users to consume the ever-growing information by posing natural language questions. Therefore, it is urgent and necessary to develop a QA system to offer consulting services all the time to relieve the stress of health services. In particular, people increasingly pay more attention to complex multi-hop questions rather than simple ones during the lasting pandemic, but the existing COVID-19 QA systems fail to meet their complex information needs. In this paper, we introduce a novel multi-hop QA system called COKG-QA, which reasons over multiple relations over large-scale COVID-19 Knowledge Graphs to return answers given a question. In the field of question answering over knowledge graph, current methods usually represent entities and schemas based on some knowledge embedding models and represent questions using pre-trained models. While it is convenient to represent different knowledge (i.e., entities and questions) based on specified embeddings, an issue raises that these separate representations come from heterogeneous vector spaces. We align question embeddings with knowledge embeddings in a common semantic space by a simple but effective embedding projection mechanism. Furthermore, we propose combining entity embeddings with their corresponding schema embeddings which served as important prior knowledge, to help search for the correct answer entity of specified types. In addition, we derive a large multi-hop Chinese COVID-19 dataset (called COKG-DATA for remembering) for COKG-QA based on the linked knowledge graph OpenKG-COVID19 launched by OpenKG①, including comprehensive and representative information about COVID-19. COKG-QA achieves quite competitive performance in the 1-hop and 2-hop data while obtaining the best result with significant improvements in the 3-hop. And it is more efficient to be used in the QA system for users. Moreover, the user study shows that the system not only provides accurate and interpretable answers but also is easy to use and comes with smart tips and suggestions.
Towards the FAIRification of Scanning Tunneling Microscopy Images
Authors: Rodani Tommaso , Osmenaj Elda , Cazzaniga Alberto , Panighel Mirco , Cristina Africh , Cozzini Stefano 
Published: August 2022

ABSTRACTIn this paper, we describe the data management practices and services developed for making FAIR compliant a scientific archive of Scanning Tunneling Microscopy (STM) images. As a first step, we extracted the instrument metadata of each image of the dataset to create a structured database. We then enriched these metadata with information on the structure and composition of the surface by means of a pipeline that leverages human annotation, machine learning techniques, and instrument metadata filtering. To visually explore both images and metadata, as well as to improve the accessibility and usability of the dataset, we developed “STM explorer” as a web service integrated within the Trieste Advanced Data services (TriDAS) website. On top of these data services and tools, we propose an implementation of the W3C PROV standard to describe provenance metadata of STM images.
“Pay No Attention to That Man Behind the Curtain”: A Critique of the Rational Choice Approach to Religion
Authors: Gauthier François , Spickard James 
Published: August 2022

Abstract
The rational choice approach to religion (RCAR) applies neoclassical economic principles to religion to create models of religious behavior. It presents both those principles and the resulting models as universal. Most critics of that approach have challenged those models’ empirical predictions. In contrast, this article develops an ‘upstream’ critique of the theory by examining the problems with its chosen approach in economics itself. The history of that discipline shows that the utility-maximizing figure of Homo economicus is a modern construct, as is the notion of a self-correcting free market. Both are contextual and ideological, not universal. Early 20th-century sociologists already provided a comprehensive and radical rebuttal of these ideas – a critique that was a major source of the early sociology of religion. Recent alternative approaches by economists show that neoclassical formalism even fails to account for basic economic phenomena. Models built on this formalism – such as RCAR – thus cannot be naively imported to explain religious action. This does not mean that the sociology of religion should avoid economics tout court. Some non-formalist economic approaches show much more promise.