bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nano-Resveratrol: A Promising Candidate for the Treatment of Renal Toxicity Induced by Doxorubicin in Rats Through Modulation of Beclin-1 and mTOR
Authors: Alhusaini Ahlam M. , Fadda Laila M. , Alanazi Abeer M. , Sarawi Wedad S. , Alomar Hatun A. , Ali Hanaa M. , Hasan Iman H. , Ali Rehab Ahmed 
Published: February 2022

Background: Although doxorubicin (DXR) is one of the most used anticancer drugs, it can cause life-threatening renal damage. There has been no effective treatment for DXR-induced renal damage until now.Aim: This work aims at examining the potential impact of nano-resveratrol (N-Resv), native resveratrol (Resv), and their combination with carvedilol (Card) against DXR-induced renal toxicity in rats and to investigate the mechanisms through which these antioxidants act to ameliorate DXR nephrotoxicity. Method: DXR was administered to rats (2 mg/kg, i.p.) twice weekly over 5 weeks. The antioxidants in question were taken 1 week before the DXR dose for 6 weeks.Results: DXR exhibited an elevation in serum urea, creatinine, renal lipid peroxide levels, endoglin expression, kidney injury molecule-1 (KIM-1), and beclin-1. On the other hand, renal podocin and mTOR expression and GSH levels were declined. In addition, DNA fragmentation was markedly increased in the DXR-administered group. Treatment with either Resv or N-Resv alone or in combination with Card ameliorated the previously measured parameters.Conclusion: N-Resv showed superior effectiveness relative to Resv in most of the measured parameters. Histopathological examination revealed amelioration of renal structural and cellular changes after DXR by Card and N-Resv, thus validating the previous biochemical and molecular results.
Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
Authors: Bischoff-Kont Iris , Primke Tobias , Niebergall Lea S. , Zech Thomas , Fürst Robert 
Published: February 2022

Rhizomes from Zingiber officinale Roscoe are traditionally used for the treatment of a plethora of pathophysiological conditions such as diarrhea, nausea, or rheumatoid arthritis. While 6-gingerol is the pungent principle in fresh ginger, in dried rhizomes, 6-gingerol is dehydrated to 6-shogaol. 6-Shogaol has been demonstrated to exhibit anticancer, antioxidative, and anti-inflammatory actions more effectively than 6-gingerol due to the presence of an electrophilic Michael acceptor moiety. In vitro, 6-shogaol exhibits anti-inflammatory actions in a variety of cell types, including leukocytes. Our study focused on the effects of 6-shogaol on activated endothelial cells. We found that 6-shogaol significantly reduced the adhesion of leukocytes onto lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs), resulting in a significantly reduced transmigration of THP-1 cells through an endothelial cell monolayer. Analyzing the mediators of endothelial cell–leukocyte interactions, we found that 30 µM of 6-shogaol blocked the LPS-triggered mRNA and protein expression of cell adhesion molecules. In concert with this, our study demonstrates that the LPS-induced nuclear factor κB (NFκB) promoter activity was significantly reduced upon treatment with 6-shogaol. Interestingly, the nuclear translocation of p65 was slightly decreased, and protein levels of the LPS receptor Toll-like receptor 4 remained unimpaired. Analyzing the impact of 6-shogaol on angiogenesis-related cell functions in vitro, we found that 6-shogaol attenuated the proliferation as well as the directed and undirected migration of HUVECs. Of note, 6-shogaol also strongly reduced the chemotactic migration of endothelial cells in the direction of a serum gradient. Moreover, 30 µM of 6-shogaol blocked the formation of vascular endothelial growth factor (VEGF)-induced endothelial sprouts from HUVEC spheroids and from murine aortic rings. Importantly, this study shows for the first time that 6-shogaol exhibits a vascular-disruptive impact on angiogenic sprouts from murine aortae. Our study demonstrates that the main bioactive ingredient in dried ginger, 6-shogaol, exhibits beneficial characteristics as an inhibitor of inflammation- and angiogenesis-related processes in vascular endothelial cells.
Prioritizing Positivity, Styles of Rumination, Coping Strategies, and Posttraumatic Growth: Examining Their Patterns and Correlations in a Prospective Study
Authors: Zięba Mariusz , Wiecheć Katarzyna , Wójcik Natalia E. , Zięba Michał J. 
Published: February 2022

ObjectivesA growing number of studies indicate that coping with the experience of a crisis event, which causes a breach in the individual’s fundamental beliefs regarding the world and his/her place in it, can result in posttraumatic growth. Positive emotions can have an undoing effect on negative emotional arousal and broaden an individual’s scope of action, and they can foster posttraumatic growth. This study aimed to examine relations between prioritizing positivity, styles of rumination, coping strategies, and posttraumatic growth.MethodsOne hundred and sixty-four Polish adults took part in the study, filling out questionnaires to measure prioritizing positivity, hope, and self-efficacy. Twelve to fifteen months later, 104 of them accepted the invitation to the second part of the study. The participants reported the intensity of rumination associated with the most critical event in their lives, which took place between the first and second stages of the study and the coping strategies they used. Posttraumatic growth and life satisfaction were also measured.ResultsResults from hierarchical regressions found that higher levels of prioritizing positivity, deliberate ruminations, and religious coping and lower level of intrusive ruminations were associated with posttraumatic growth. The results also indicate that self-esteem was a significant predictor of life satisfaction.ConclusionsThe results of the prospective study confirm that individual differences in prioritizing positivity can relate to a process of posttraumatic growth. Prioritizing positivity was associated with the use of an active coping strategy and deliberate but not intrusive ruminations. Previous studies on the role of prioritizing positivity have focused on the impact on the level of wellbeing of seeking positive emotions in everyday life. Our results show the importance of prioritizing positivity in coping with stress and trauma. These results can be used to design effective psychological intervention techniques to support people experiencing trauma and psychological crises. The results also indicate that life satisfaction has different predictors from posttraumatic growth.
Imaging Insights Into Abdominal Wall Function
Authors: Read John W. , Ibrahim Nabeel , Jacombs Anita S. W. , Elstner Kristen E. , Saunders Jeni , Rodriguez-Acevedo Omar 
Published: February 2022

PurposeThe successful repair of any complex ventral hernia requires a thorough understanding of the underlying anatomical defect and its functional context. We describe an improved “functional” approach to CT imaging of the abdominal wall that can facilitate this understanding and assist surgical planning.MethodsThis invited article reports the observational experience gained from the functional abdominal wall CT examinations of 88 patients who underwent complex ventral hernia repair using pre-operative Botulinum toxin A (BTA) infiltration of the lateral oblique abdominal muscles as well as a further eight patients with diastasis rectus abdominis who were examined to exclude ventral hernia.ResultsThe use of a functional CT protocol which supplements resting images with additional “crunching” images (acquired with the abdominal wall muscles all strongly contracted) can significantly improve the demonstration of ventral hernia defects. Crunching acquisitions can also help differentiate true hernias from dysfunctional bulges, identify muscle denervation or atrophic changes, reveal otherwise occult hernias that may be missed on resting or Valsalva images alone, and assist the pre-operative assessment of BTA effect.ConclusionA more functional approach to pre-operative CT imaging of the abdominal wall can significantly improve the understanding of complex ventral hernia defects and help formulate effective surgical plans that achieve low recurrence rates and good functional outcomes.
Effect of Dexmedetomidine-Assisted Intravenous Anesthesia on Gastrointestinal Motility in Colon Cancer Patients After Open Colectomy
Authors: Ou Chaopeng , Kang Shiyang , Xue Ruifeng , Lai Jielan , Zhang Yingjun 
Published: February 2022

BackgroundTo explore the effect of dexmedetomidine (Dex)-assisted intravenous anesthesia on gastrointestinal motility in patients with colon cancer (CC) after open colectomy.MethodsA total of 102 patients with CC, undergoing open colectomy in our hospital from January 2018 to January 2020, were selected and randomly divided into an observation group (n = 51) and a control group (n = 51). The patients in the control group received a routine combination of intravenous and inhalation anesthesia (CIIA), while those in the observation group received a Dex-assisted CIIA. The systolic blood pressure (SBP), the diastolic blood pressure (DBP), heart rate (HR), and the mean arterial pressure (MAP) were compared at different time points between the two groups. In addition, the intraoperative general conditions, the dosage of anesthetics, and the recovery of gastrointestinal functions were also compared between the two groups. Moreover, before operation and at 24 h after operation, the levels of serum gastrin (GAS) and plasma motilin (MTL) were detected by radioimmunoassay, and the level of plasma cholecystokinin (CCK) was detected by an enzyme-linked immunosorbent assay. The incidence of gastrointestinal complications was recorded in both groups.ResultsAt T1-T3, the HR, SBP, DBP, and MAP levels were lower in both groups than those at T0. In addition, they were also lower in the observation group than those in the control group, showing significant differences (p &lt; 0.05). The dosage of propofol and remifentanil in the observation group was lower than that in the control group, and there was a significant difference (p &lt; 0.05). In the observation group, the postoperative first exhaust time, first defecation time, first ambulation time, and first feeding time were all earlier than those in the control group with significant differences (p &lt; 0.05). After the operation, the observation group had higher levels of GAS and MTL but a lower level of CCK than the control group, and the differences were significant (p &lt; 0.05). The incidence rate of gastrointestinal complications in the observation group (7.04%) was lower than that in the control group (19.61%), and there was a significant difference (χ2 = 4.346, p &lt; 0.05).ConclusionsDex-assisted intravenous anesthesia can facilitate the recovery of gastrointestinal motility, can regulate the levels of gastrointestinal hormones, and can stabilize the levels of hemodynamic indexes in patients with CC after open colectomy.
Molecular Mechanisms of Lipopolysaccharide (LPS) Induced Inflammation in an Immortalized Ovine Luteal Endothelial Cell Line (OLENDO)
Authors: Gram Aykut , Kowalewski Mariusz P. 
Published: February 2022

Escherichia coli (E. coli) is the most common Gram-negative bacterium causing infection of the uterus or mammary gland and is one of the major causes of infertility in livestock. In those animals affected by E. coli driven LPS-mediated infections, fertility problems occur in part due to disrupted follicular and luteal functionality. However, the molecular mechanisms by which LPS induces inflammation, and specifically, the role of LPS in the disruption of capillary morphogenesis and endothelial barrier function remain unclear. Here, we hypothesized that LPS may lead to alterations in luteal angiogenesis and vascular function by inducing inflammatory reactions in endothelial cells. Accordingly, OLENDO cells were treated with LPS followed by evaluation of the expression of selected representative proinflammatory cytokines: NF-kB, IL6, IL8, TNFα, and ICAM 1. While TNFα was not affected by treatment with LPS, transcripts of NF-kB, IL6, and IL8 were affected in a dosage-dependent manner. Additionally, the activity of TLR2 and TLR4 was blocked, resulting in suppression of the LPS-induced expression of ICAM 1, NF-kB, IL6, and IL8. Inhibition of the PKA or MAPK/ERK pathways suppressed the LPS-stimulated expression of NF-kB, IL6, and IL8, whereas blocking the PKC pathway had the opposite effect. Furthermore, LPS-induced phosphorylation of Erk1 and Erk2 was inhibited when the TLR4 or MAPK/ERK pathways were blocked. Finally, LPS seems to induce inflammatory processes in OLENDO cells via TLR2 and TLR4, utilizing different signaling pathways.
Efektivitas Program Magang Siswa SMK di Kota Serang Dengan Menggunakan Metode CIPP di Era Adaptasi New Normal Pandemi Covid-19
Authors: Sudaryono  , Elmanda Vonda , Purba Angelia Efrida , Ayu Sanjaya Yulia Putri , Julianingsih Dwi 
Published: February 2022

Program magang menjadi sebuah program yang penting dalam lembaga pendidikan khususnya Sekolah Menengah Kejuruan (SMK) di Indonesia. Tujuan penelitian ini adalah untuk mengevaluasi tingkat keberhasilan Program tersebut dalam mengasah keterampilan siswa dan mempersiapkan siswa dalam dunia kerja. Penelitian ini merupakan penelitian pendekatan evaluasi dengan model CIPP atau context, input, process, dan product. Penelitian dilakukan kepada 100 orang siswa SMK yang telah menyelesaikan program magang selama masa pandemi Covid-19. Hasil penelitian menunjukkan bahwa pelaksanaan program magang mulai dari context, input, process, hingga product menunjukkan kategori yang baik, sehingga program ini masih layak untuk dilanjutkan. Kepala SMK kedepannya dapat memberikan motivasi siswa terkait seluruh unsur program magang yang dilakukan, agar mutu program ini selaras dengan tujuan Pendidikan Nasional dalam meningkatkan mutu sumber daya manusia yang terpercaya dan siap pakai.
Predictive and Prognostic Significance of the State of Gene TOP2A as a Marker of Anthracyclines Sensitivity in Patients with Breast Cancer
Authors: Бармотько М.А. 
Published: February 2022

Представлен обзор литературы, посвященный изучению значимости состояния гена ТОР2А как фактора прогноза исхода заболевания и эффективности лечения антрациклинами у пациентов с раком молочной железы.A literature review was presented and devoted to study of significance gene TOP2A state as a factor in predicting the outcome of the disease and the efficacy of anthracyclines treatment in patients with breast cancer.
La educación como práctica de “domesticación”: la singularidad y la diversidad amenazadas
Authors: Felice María Fernanda 
Published: February 2022

El presente trabajo fue desarrollado en la instancia de evaluación final correspondiente a la Especialización en Alfabetización e Inclusión, carrera de posgrado que ofrece el Centro de Estudios Interdisciplinarios (UNR). El mismo se propuso reflexionar acerca de ciertas prácticas educativas que, en reiteradas ocasiones, se convierten en prácticas de “domesticación” que atentan contra la diversidad inherente a todos los sujetos y a todos los aprendizajes.
Se desarrolló un estudio de casos específico, que analizó el proceso de construcción de la lectura y la escritura de una niña. Es un trabajo de intervención fonoaudiológica, en el cual se explicitan intervenciones terapéuticas para promover el desarrollo del lenguaje y el aprendizaje de la lengua escrita.
Se observa que la institución escolar no ha sido capaz de valorar los saberes que la niña expone, como lectora y escritora. Las dificultades registradas remiten, fundamentalmente, a las diferencias entre oralidad y escritura, las normas impuestas por los géneros discursivos y los aspectos no alfabéticos del aprendizaje de la lengua escrita.
El trabajo interdisciplinario permitió correr la mirada del “déficit”, para tomar en consideración las posibilidades de la niña, y promovió avances significativos en el aprendizaje de la lengua escrita.
Inclusión socio-educativa y pandemia. Aportes de la teoría de la actividad histórico-cultural para la reflexión sobre la práctica educativa
Authors: Noriega Javier , Erausquin Cristina 
Published: February 2022

El trabajo analiza aportes de la Teoría de la Actividad Histórico Cultural como herramienta de investigación-intervención para acompañar y potenciar los esfuerzos de reflexión sobre la práctica desarrollados por equipos escolares para alcanzar la inclusión educativa, como objetivo de las políticas públicas tanto en la coyuntura provocada por el COVID-19 como a futuro.
Se establece una perspectiva conceptual sobre inclusión psico-socio-educativa en la cual se inscriben los trabajos de la presente línea de indagación, sostenida en sucesivos proyectos de investigación y desarrollo, acreditados y subsidiados en una universidad pública. Se delimitan algunas particularidades que se han producido en el trabajo institucional para la inclusión psico-socio-educativa, a raíz de las medidas adoptadas por la pandemia del Covid-19.
Se establecen los principales desarrollos de la Teoría de la Actividad Histórico Cultural, delimitando sus conceptos clave a través del recorrido por sus Cuatro Generaciones. Finalmente se describen los Talleres de Reflexión Sobre la Práctica Profesional en Inclusión psico-socio-educativa como una intervención formativa sustentada en dicha teoría, para promover ciclos de aprendizaje expansivo. Esto se perseguirá fomentando agencialidad en los sujetos para cruzar fronteras, tanto profesionales como personales, y moldear objetos/objetivos de actividad, a la vez que formas de trabajo progresivamente más potentes y resilientes en el tiempo.
El mérito de ser autónomo: en torno a la igualdad de opotunidades y al tipo de estudiante esperado en un grupo de escuelas secundarias
Authors: Di Piero Emilia 
Published: February 2022

En este trabajo se indagan representaciones de docentes y actores clave en torno al tipo de estudiante esperado en un grupo prestigioso de escuelas secundarias dependientes de la Universidad Nacional de La Plata, en la ciudad capital de la Provincia de Buenos Aires, Argentina. Si bien el mérito como criterio de selección educativa presente en los exámenes de ingreso dejó de dirimir la admisión a las escuelas a partir del retorno de la democracia al país en los años ‘80, la ideología meritocrática persiste en las instituciones educativas en la actualidad. A partir del análisis de las representaciones mencionadas se analiza el tipo de estudiante esperado en estas escuelas: un estudiante “autónomo”. Se concluye que, más allá de que se trata de secundarias que desde los años ´80 cuentan con un sorteo público “abierto” como política de admisión, la noción de mérito perdura en el requisito de “autonomía” que actúa como premisa normalizadora y legitima desigualdades.
El enfoque metodológico implicó un estudio de caso múltiple. Entre los años 2012 y 2016 se realizaron observaciones, entrevistas en profundidad a trece actores “clave”, sesenta y siete entrevistas semiestructuradas a docentes seleccionados aleatoriamente y análisis de documentos.
Multi-degrees-of-freedom swimmer using an ultrasonic longitudinal transducer
Authors: Tanimura Ryo , Kong Deqing , Aoyagi Manabu 
Published: February 2022

Abstract
Acoustic underwater propulsion systems based on an ultrasonic transducer have been studied. In previous research, the self-propelled acoustic swimmer using thickness-vibration-mode transducer is evaluated widely. The thickness-vibration-mode transducer is excited in the thickness and radial direction. Because the acoustic propulsion system is based on the acoustic driving force, the vibration in the radial direction is hard to provide the propulsion thrust. In this study, a cylindrical transducer, the pure longitudinal vibrator, is evaluated for the acoustic underwater propulsion system. A prototype swimmer with multiple transducers is designed and fabricated. The admittance characteristics of the cylindrical transducer are investigated in air and in water. The zero speed propulsion and no load speed are measured in water. Multi-degrees-of-freedom swimmer with the multiple cylindrical transducers is evaluated. Because of the small size, high power density, simple structure and multi-degrees-of-freedom, self-propelled acoustic swimmer is suitable for applications such as inspection and repairment robots in a liquid environment.
Impact of the COVID-19 Pandemic on Integrated Health Service for Child (Posyandu) Management in Palu City
Authors: Wandira Bertin Ayu , Hermiyanti Hemiyanty , Suwendro Novi Inriyanny , Suarayasa Ketut 
Published: February 2022

BACKGROUND: Posyandu is an integrated health service for the child, a form of community-based health effort managed from, for, and with the community. It is addressed to empower the community and provide convenience to the community in obtaining basic health services. AIM: This study aims to obtain an overview of the impact of the COVID-19 pandemic on Posyandu management in Palu City, including the status of Posyandu development, Posyandu activities,Posyandu cadre activities, and Posyandu supervision practices by the Community Health Center (Puskesmas) during the COVID-19 pandemic. METHODS: It used a mixed study method by combining two study methods conducted previously, namely, quantitative and qualitative. The study also carried out Posyandu observations and interviews with several informants. RESULTS: The results showed that during the COVID-19 pandemic: (1) Posyandu development status did not decrease, remained the same as before; (2) Posyandu activities were prioritized on toddler immunization. After 3 months of the COVID-19 pandemic, Posyandu activities returned to normal; (3) Posyandu cadre activities included registration, weighing, recording, and counseling; (4) Posyandu supervision activities were focused on monitoring the growth and development of toddlers but could not run optimally due to the busyness of Community Health Center (Puskesmas) officers dealing with COVID-19; and (5) constraints: The unavailability of infrastructure for implementing health protocols in Posyandu and not accustomed to implementing health protocols. Challenges: The demands of the community using Posyandu so that the Posyandu applies standard health protocols, and the workload of Puskesmas officers was excessive (basic tasks and additional tasks for COVID-19). Efforts: Following the instructions of the Palu City Health Office to implement health protocols at the Posyandu according to standards. CONCLUSION: During the COVID-19 pandemic, Posyandu ran normally, except for the first 3 months of the pandemic, when the service was interrupted because the Posyandu was closed. Posyandu management indicators included Posyandu status conditions (primary, middle, full-time, and independent strata), Posyandu main activities (monitoring growth and development of toddlers), cadre activities (registration, weighing, recording, and counseling), and supervision activities running as usual.