bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and evaluation of haltere-mimicking gyroscope for three-axis angular velocity sensing using a haltere-mimicking structure pair
Authors: Kim Chulhong , Park Junghyun , Kim Taeyup , Kim Jee-Seong , Seong Jeongmo , Shim Hyungbo , Ko Hyoungho , Cho Dong-Il (Dan) 
Published: October 2022

Abstract
This paper presents a three-axis biomimetic gyroscope, mimicking the haltere of Diptera. Diptera use a club-shaped mechanosensory organ called the haltere to get the three-axis angular velocity information, namely roll, pitch and yaw axes, for flight control. One pair of halteres is physically connected to the wings of Diptera that vibrate in antiphase to the flapping wings in ambient air. They sense the Coriolis force and relay angular velocity information to the Diptera. As an alternative to the conventional micro-electro-mechanical system gyroscopes which are widely used in robotics, many research groups have attempted to mimic the haltere. However, no previous study succeeded in measuring all three-axis components of angular velocity, due to various shortcomings. In this paper, we developed the first three-axis haltere-mimicking gyroscope. Two perpendicularly positioned haltere-mimicking structures that can vibrate at a 180° amplitude were mechanically integrated into a robot actuator. Two accelerometers, placed at the tip of each structure, were employed to measure the Coriolis force. The performance of the novel biomimetic gyroscope was measured in all rotational directions, using a motion capture system as the ground truth. One-axis input experiments were performed 240 times at different input magnitudes and directions, and the measured orientation error was less than ±2.0% in all experiments. In 80 three-axis input experiments, the orientation error was less than ±3.5%.
Projected changes in mild weather frequency over China under a warmer climate
Authors: Zhang Jintao , You Qinglong , Ren Guoyu , Ullah Safi 
Published: October 2022

Abstract
Previous studies have largely focussed on changes in mean climate state and climate extremes under a warmer climate, and little is known about changes in mild weather, which is a positive and pleasant condition and is highly related to human outdoor activities. Although changes in observed mild weather frequency over China, and their drivers, have been revealed, the understanding of how mild weather evolves with projected warming is still limited. Here, we examine future changes in mild weather frequency over China based on comprehensive thermal comfort indices, and dynamically downscaled climate projections produced by the Regional Climate Model version 4 within the framework of the Coordinated Regional Climate Downscaling Experiment—Coordinated Output for Regional Evaluations. We demonstrate that changes in mild weather frequency in a warmer future exhibit remarkable regional discrepancy. In particular, densely populated southeastern China will experience a robust decrease in mild weather relative to the current level, although a general increasing trend is observed in this area over recent decades. On a seasonal scale, the decrease in mild weather in summer overwhelms the increase in spring and autumn, and this is more prominent in warmer regions. Regarding the drivers, it is suggested that changes in mild weather frequency are dominated by elevated temperatures, with little contribution from relative humidity, wind speed, and sunshine duration.
Growing hydropower potential in China under 1.5 °C and 2.0 °C global warming and beyond
Authors: Qi Wei , Feng Lian , Liu Junguo , Yang Hong 
Published: October 2022

Abstract
Renewable energy is the key to reducing greenhouse gas emissions, and is one of the most concerning issues worldwide. China has the largest hydropower potential in the world. Yet, how China’s hydropower potential will change under 1.5 °C and 2.0 °C global warming and beyond remains unknown. Here, we find that China’s hydropower will increase greatly because of global warming. Gross hydropower potential (GHP) will increase by about one-half compared to the baseline period (1986–2015) under 1.5 °C and 2.0 °C warming, and about two-thirds under 4.5 °C warming. The spatial and temporal changes in GHP will vary largely. GHP will increase relatively more in summer than in winter, and more in Southwest China than in other regions. Compared to GHP, increases in per-capita GHP will be relatively less under 1.5 °C (5%) and 2.0 °C (7%) warming, but of a similar magnitude under 4.5 °C warming (71%). This study provides important information on China’s hydropower potential changes under global warming.
AugLiChem: data augmentation library of chemical structures for machine learning
Authors: Magar Rishikesh , Wang Yuyang , Lorsung Cooper , Liang Chen , Ramasubramanian Hariharan , Li Peiyuan , Barati Farimani Amir 
Published: October 2022

Abstract
Machine learning (ML) has demonstrated the promise for accurate and efficient property prediction of molecules and crystalline materials. To develop highly accurate ML models for chemical structure property prediction, datasets with sufficient samples are required. However, obtaining clean and sufficient data of chemical properties can be expensive and time-consuming, which greatly limits the performance of ML models. Inspired by the success of data augmentations in computer vision and natural language processing, we developed AugLiChem: the data augmentation library for chemical structures. Augmentation methods for both crystalline systems and molecules are introduced, which can be utilized for fingerprint-based ML models and graph neural networks (GNNs). We show that using our augmentation strategies significantly improves the performance of ML models, especially when using GNNs. In addition, the augmentations that we developed can be used as a direct plug-in module during training and have demonstrated the effectiveness when implemented with different GNN models through the AugliChem library. The Python-based package for our implementation of Auglichem: Data augmentation library for chemical structures, is publicly available at: https://github.com/BaratiLab/AugLiChem.
Development and implementation of a standardized process for identifying ambulatory pharmacy clinical outcomes measures
Authors: Summerlin Charles M , Vest Mary-Haston , Valgus John M , Deyo Zachariah M , Alexander Maurice D , Waldron Kayla M 
Published: October 2022

AbstractPurposeThere is minimal available guidance on the process for selection of clinical outcomes measures to demonstrate the impact of clinic-based pharmacists (CBPs) despite an increased need and desire for outcomes data. The overall aims of this project were to (1) develop a standardized process for identifying clinical outcomes measures impacted by CBPs and (2) identify and prioritize potential clinical outcomes measures to track for CBPs within 4 specialty clinic pilot sites.MethodsTo develop a standardized process for identification and prioritization of measures, 4 consecutive Plan-Do-Study-Act (PDSA) cycles were performed with 4 different specialty clinics serving as pilot sites. Following each pilot cycle, rapid cycle improvements were implemented. A modified Delphi methodology served as the framework for measure selection and included gathering expert stakeholder insights regarding importance, feasibility, and validity of potential measures. Measures were identified via environmental scan of existing validated quality metrics, clinical guidelines, and other relevant literature.ResultsThe primary outcome for this project was the development and refinement of a standardized process for measure identification and prioritization. The secondary outcome was narrowed and ranked lists of stakeholder-prioritized measures for 4 CBP-embedded pilot specialty clinics. These lists included 12 cardiothoracic transplant, 6 breast oncology, 9 neurology, and 7 gynecologic oncology measures.ConclusionThe measure identification and prioritization process developed was successfully utilized to identify and prioritize outcomes measures to track for 4 CBP-embedded specialty clinics. Due to the successful use of the process in a variety of specialty clinics, the standardized process has significant potential for expansion.
Benzene Exposure From Selected Work Tasks on Offshore Petroleum Installations on the Norwegian Continental Shelf, 2002–2018
Authors: Ridderseth Hilde , Daltveit Dagrun Slettebø , Hollund Bjørg Eli , Kirkeleit Jorunn , Kromhout Hans , Krüger Kirsti , Aasbø Kari , Bråtveit Magne 
Published: October 2022

Abstract

Objectives
Work on offshore petroleum installations may cause exposure to benzene. Benzene is a carcinogenic agent, and exposure among workers should be as low as reasonably practicable. We aimed to assess short-term (less than 60 min) benzene exposure from the most frequent work tasks on offshore installations on the Norwegian continental shelf and identify determinants of exposure. In addition, we aimed to assess the time trend in task-based benzene measurements from 2002 to 2018.

Methods
The study included 763 task-based measurements with a sampling duration of less than 60 min, collected on 28 offshore installations from 2002 to 2018. The measurements were categorized into 10 different tasks. Multilevel mixed-effect Tobit regression models were developed for two tasks: sampling and disassembling/assembling equipment. Benzene source, season, indoors or outdoors, design of process area, year of production start, sampling method, and work operation were considered as potential determinants for benzene exposure in the models.

Results
The overall geometric mean (GM) benzene exposure was 0.02 ppm (95% confidence intervals 95%(CI: 0.01–0.04). The pipeline inspection gauge (PIG) operation task was associated with the highest exposure, with a GM of 0.33 ppm, followed by work on flotation cells, disassembling/assembling, and sampling, with GMs of 0.16, 0.04, and 0.01 ppm, respectively. Significant determinants for the disassembling/assembling task were work operation (changing or recertifying valves, changing or cleaning filters, and breaking pipes) and benzene source. For sampling, the benzene source was a significant determinant. Overall, the task-based benzene exposure declined annually by 10.2% (CI 95%: −17.4 to −2.4%) from 2002 to 2018.

Conclusions
The PIG operation task was associated with the highest exposure out of the ten tasks, followed by work on flotation cells and when performing disassembling/assembling of equipment. The exposure was associated with the type of benzene source that was worked on. Despite the decline in task-based exposure in 2002–2018, technical measures should still be considered in order to reduce the exposure.
Identification of potential driver mutations in glioblastoma using machine learning
Authors: Pandey Medha , Anoosha P , Yesudhas Dhanusha , Gromiha M Michael 
Published: October 2022

Abstract
Glioblastoma is a fast and aggressively growing tumor in the brain and spinal cord. Mutation of amino acid residues in targets proteins, which are involved in glioblastoma, alters the structure and function and may lead to disease. In this study, we collected a set of 9386 disease-causing (drivers) mutations based on the recurrence in patient samples and experimentally annotated as pathogenic and 8728 as neutral (passenger) mutations. We observed that Arg is highly preferred at the mutant sites of drivers, whereas Met and Ile showed preferences in passengers. Inspecting neighboring residues at the mutant sites revealed that the motifs YP, CP and GRH, are preferred in drivers, whereas SI, IQ and TVI are dominant in neutral. In addition, we have computed other sequence-based features such as conservation scores, Position Specific Scoring Matrices (PSSM) and physicochemical properties, and developed a machine learning-based method, GBMDriver (GlioBlastoma Multiforme Drivers), for distinguishing between driver and passenger mutations. Our method showed an accuracy and AUC of 73.59% and 0.82, respectively, on 10-fold cross-validation and 81.99% and 0.87 in a blind set of 1809 mutants. The tool is available at https://web.iitm.ac.in/bioinfo2/GBMDriver/index.html. We envisage that the present method is helpful to prioritize driver mutations in glioblastoma and assist in identifying therapeutic targets.
Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease
Authors: Li Xiaohang , Ospitalieri Simona , Robberechts Tessa , Hofmann Linda , Schmid Christina , Rijal Upadhaya Ajeet , Koper Marta J , von Arnim Christine A F , Kumar Sathish , Willem Michael , Gnoth Kathrin , Ramakers Meine , Schymkowitz Joost , Rousseau Frederic , Walter Jochen , Ronisz Alicja , Balakrishnan Karthikeyan , Thal Dietmar Rudolf 
Published: October 2022

Abstract
Alzheimer’s disease is neuropathologically characterized by the deposition of the amyloid β-peptide (Aβ) as amyloid plaques. Aβ plaque pathology starts in the neocortex before it propagates into further brain regions. Moreover, Aβ aggregates undergo maturation indicated by the occurrence of post-translational modifications. Here, we show that propagation of Aβ plaques is led by presumably non-modified Aβ followed by Aβ aggregate maturation. This sequence was seen neuropathologically in human brains and in amyloid precursor protein transgenic mice receiving intracerebral injections of human brain homogenates from cases varying in Aβ phase, Aβ load and Aβ maturation stage. The speed of propagation after seeding in mice was best related to the Aβ phase of the donor, the progression speed of maturation to the stage of Aβ aggregate maturation. Thus, different forms of Aβ can trigger propagation/maturation of Aβ aggregates, which may explain the lack of success when therapeutically targeting only specific forms of Aβ.
Oral Presentation No. 46 The effect of covid-19 vaccine on the endothelial function
Authors: Makni Ahmed , Ghrab Aiman , Gargouri Rania , Charfeddine Salma , Bahloul Amine , Ellouze Tarek , Hammami Rania , Triki Faten , Jabeur Mariem , Mallek Souad , Abid Leila 
Published: October 2022

Abstract

Background
Covid-19 vaccine was associated with several complications such as thromboembolic complications. The exact mechanism is not well established. Since covid 19 virus caused severe endothelial dysfunction, we suspect that the vaccine with a similar immunological response may cause this dysfunction.

Aim
To study the effect of covid-19 vaccine on endothelial function.

Methods
We conducted a prospective study. The endothelial function was clinically assessed using a post-occlusive reactive hyperemia protocol with finger thermal monitoring device. Endothelial quality index (EQI) was assessed at inclusion before the first dose of coronavirus vaccine and 30 days later.

Results
20 patients were included in our study. Their mean age was 41 years old [23–65]. The sex ratio was 3/2. They were all healthy individuals. The Majority, 75% of our patients, have impaired their endothelial function 30 days after the first dose of covid-19 vaccine.

Conclusion
The Covid-19 vaccine effect on endothelial function may be responsible for its complications.
Key words: Covid-19 vaccine, endothelial dysfunction
Oral Presentation No. 69 Chronotropic incompetence: still a suitable indicator?
Authors: Cruz Isabel , Oliveira Inês , Bragança Bruno , Lopes Rafaela , Santos Rui , Queirós Conceição , Andrade Aurora 
Published: October 2022

Abstract

Background
Chronotropic incompetence (CI) is defined as the inability to increase heart rate (HR) in response to increased activity. It is common in patients (pts) with cardiovascular (CV) disease, being a predictor of major adverse CV events; however, its importance is often underestimated in clinical practice.

Purpose
Evaluate the prognostic value of CI in pts with known coronary artery disease (CAD) who performed Bruce protocol treadmill testing.

Methods
Unicentric, retrospective analysis of consecutive pts with known CAD who underwent Bruce protocol treadmill testing between 2009 and 2010. Chronotropic index (ChI) was calculated as:(peak HR–resting HR)/(220–age–resting HR). CI was defined as ChI &lt; 80% (&lt; 62% in pts prescribed with beta-blockers). Pts were divided in two groups-G1: CI and G2: normal chronotropic response. Events were defined as: de novo heart failure (HF), CAD progression, myocardial infarction (MI), stroke, all-cause mortality and CV mortality.

Results
A total of 471 pts were included (87.3% male, mean age 69 ± 9.8 years). Mean follow-up was 9.7 years. The groups were similar regarding sex, age, body mass index, diabetes, arterial hypertension, dyslipidemia, MI and left ventricle ejection fraction (P &gt; 0.050). CI was identified in 27.4% pts. Comparing G1 vs. G2, no differences were found related to all-cause mortality, de novo HF, CAD progression, MI and stroke (P &gt; 0.050). However, statistically significant differences were found regarding CV mortality (P = 0.028).

Conclusion
CI is a simple an easily available parameter that shows a clear association with CV mortality in a long-term follow-up of pts with CAD.
Oral Presentation No. 75 Impact of thoracic aortic calcification measured by computed tomography in clinical outcomes in patients undergoing cardiac surgery
Authors: Cabral Margarida , Carvalho Diana , Veiga Rita , Carvalho Mónica , Ferreira Wilson , Faria Rita , Ladeiras-Lopes Ricardo , Ferreira Nuno 
Published: October 2022

Abstract
The presence of thoracic aortic calcification (TAC) has been shown to increase the risk of cardiovascular and cerebrovascular events. Few studies have evaluated the relationship between CT measured by computed tomography (CT) before cardiac surgery and clinical outcomes, and the relationship is still unclear.
This study aimed to analyse the impact on clinical outcomes of the presence of TAC in patients undergoing cardiac surgery. A retrospective unicentre analysis of patients undergoing a noncontrast CT prior to cardiac surgery was performed. TAC was quantified using a volume-rendering method. The percentiles of TAC volume (TACV) were used to determine the relative standing. Demographic data, risk factors and clinical outcomes were comparable between groups. A P-value &lt; 0.05 is statistically significant.
The mean TACV was 2.45 ± 2.79 cm3, and the median and 75th percentiles were 1.45 and 4.06 cm3, respectively. Of the total of 121 patients, 26 (21.5%) had high TACV. Table 1 shows the baseline demographic and risk factors. There was no significant difference in risk factors and personal history between groups except for age (P-value = 0.02), hypertension (P-value = 0.04) and coronary artery disease (P-value &lt; 0.01). Regarding clinical outcomes, there was no significant difference in clinical outcomes except for acute kidney failure (P-value = 0.04), which was not significant in multivariate analysis.
In conclusion, aortic calcification is a recurrent finding, to which there seems to be a contribution from hypertension-related vascular damage, especially in older ones. In patients undergoing cardiac surgery, TACV appears not to be related to clinical outcomes in multivariate analysis. However, large-scale studies are needed to confirm these results.
Oral Presentation No. 81 A STEMI case with sub-occlusive lesion and high thrombotic burden – discussing a tailored approach
Authors: Lima Maria Rita , Raposo Luís , Albuquerque Francisco , Oliveira Afonso Félix , Almeida Manuel , Abecasis João , Mendes Miguel 
Published: October 2022

Abstract
A 57-year-old man was admitted with an anterior wall STEMI. The patient had a past medical history of pulmonary thromboembolism after an abdominal surgery and peripheral artery disease. After receiving loading doses of aspirin and unfractionated heparin, the patient underwent emergent coronary angiography (CA), that revealed a high thrombotic sub-occlusive lesion in the middle left anterior descending artery (mLAD), with TIMI 3 flow. At the time of CA, the ST elevation had disappeared, and the patient was asymptomatic. PCI had the risk of distal embolization and wiring of the false lumen if a dissection was present. Given the patient stability and absence of pain, the team decided to optimize anti-thrombotic therapy - aspirin + ticagrelor + enoxaparin - and repeat the CA within 72–96 h. The patient remained asymptomatic without angina or heart failure. Repeated CA showed a significant reduction of thrombus in the mLAD, maintaining TIMI 3 flow. A non-obstructive lesion was noted, being unclear if there was plaque rupture or localized dissection. Coronary CT angiography (CCTA) showed a coronary calcium score of 0 and an endoluminal flap in the mLAD, with a partial non-obstructive thrombosis. Echocardiography showed preserved LVEF without segmental abnormalities. Given the good results of anti-thrombotic therapy, the patient was discharged with aspirin, clopidogrel and rivaroxaban 2.5 mg 2id for 2 months and PCI was not performed. A follow-up CCTA within 2 months was scheduled. This case illustrates a complex STEMI case with a high thrombotic burden. The best strategy in such cases is open to debate.
Oral Presentation No. 84 Initial clinical experience with 6-hour enoxaparin regimen in opiate-treated patients undergoing primary percutaneous coronary intervention
Authors: Elamin Nadir , Ow Kok Weng , Parker William A E , Nelson Thomas A , Middle Janet , Hanson Jessica , Moyle Bethany , Krishnamurthy Arvindra , Barmby David , Morgan Kenneth , Adam Zulfiquar , Rothman Alexander , Morris Paul , Iqbal Javaid , Hall Ian , Conway Dwayne , Richardson James , Gunn Julian P , Storey Robert F 
Published: October 2022

Abstract

Background
Opioid treatment delays the onset of oral P2Y12 inhibitors in patients with acute ST-segment elevation myocardial infarction (STEMI), leading to suboptimal antithrombotic therapy during primary percutaneous coronary intervention (PPCI).

Material and methods
We retrospectively compared using a prolonged enoxaparin regimen (0.75 mg/kg bolus followed by 6-hour intravenous infusion) to using unfractionated heparin (UFH) with or without tirofiban in opioid-treated patients with STEMI who underwent PPCI. We compared the proportions of acute stent thrombosis (AST) and bleeding events according to the bleeding academic research consortium (BARC) within 24 hours post-PPCI.

Results
270 opioid-treated patients with a mean age of 63 [SD ± 12] years were enrolled, of which 49 (18%) were with diabetes mellitus (DM). 90 (34%) patients (mean age 61 [SD ± 11] years) received enoxaparin, 110 (41%) (mean age 65 [SD ± 14] years) UFH with tirofiban, and 69 (25%) (mean age 63 [SD ± 12] years) UFH only. Compared to the other strategies, a higher proportion of DM was observed in the enoxaparin-treated group (21%). No AST was associated with enoxaparin compared to 2 (1.8%) events in UFH with tirofiban and 1 (1.4%) in UFH only. The rate of severe bleeding events (BARC 2 and 3) was significantly lower in the enoxaparin-treated patients than in UFH with tirofiban (0 (0%) vs. 8 (7%), P = 0.01). 3 enoxaparin-treated patients needed switching to tirofiban as a bailout strategy due to distal vessel embolisation.

Conclusions
The novel 6-hour enoxaparin regimen is safe during PPCI and was associated with fewer bleeding events than UFH with tirofiban.