bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Magnitude of community-based health insurance utilization and associated factors in Bassona Worena District, North Shoa Zone, Ethiopia: a community-based cross-sectional study”
Authors: Getahun Tomas , Teklesilassie Lakech , Habtemichael Mizan , Abebe Yonas , Getahun Helen 
Published: November 2022

Abstract
Introduction
The health insurance system has been proven to offer effective and efficient health care for the community, particularly community-based health insurance is expected to ensure health care access for people with low economic status and vulnerable groups. Despite the significance of evidence-based systems and implementation, there is a limited report about the magnitude of CBHI utilization. Therefore, this study was done to assess factors associated with community-based health insurance utilization in Basona Worena District, North Shewa Zone, Ethiopia.

Method
A community-based cross-sectional study was employed. We have included 530 households from 6 randomly selected kebeles. The data was entered using Epi-Data V 3.1 and exported to SPSS version 20.0 for statistical analysis. Bi-variable and multivariable logistic regression analyses were computed to determine factors associated with community-based health insurance utilization.

Result
The study finding shows that 58.6% of the respondents were members of community-based health insurance. Respondents who had primary and secondary education levels were 2 times more likely to be members than those who had no formal education. As compared to those who had awareness, respondents who had no awareness about CBHI were 0.27 times less likely to be insured. Respondents who did not experience illness were 0.27 times less likely to be members than respondents who experienced illness.

Conclusion
Educational status, awareness about CBHI, perception of CBHI scheme and illness experience of family influence CBHI utilization. There is a need to strengthen awareness creation to improve the CBHI utilization.
Social return on investment economic evaluation of supportive care for lung cancer patients in acute care settings in Australia
Authors: Hyatt Amelia , Chung Holly , Aston Ruth , Gough Karla , Krishnasamy Meinir 
Published: November 2022

Abstract
Background
Unmanaged consequences of cancer and its treatment are high among patients with lung cancer and their informal carers, resulting in avoidable healthcare use and financial burden. Provision of cancer supportive care addressing the impacts of cancer and its treatment has demonstrated efficacy in mitigating these consequences; however, globally, there is a lack of investment in these services. Paucity of robust economic evidence regarding benefit of cancer supportive care has limited policy impact and allocation of resources. This study therefore utilised a Social Return on Investment (SROI) methodology to conduct a forecast evaluation of lung cancer supportive care services, to ascertain potential social value and return on investment.

Methods
An SROI economic evaluation model was developed using qualitative stakeholder consultations synthesised with published evidence to develop the inputs, outcomes and financial value associated with the delivery of a hypothetical model of quality lung cancer supportive care services over a one and five year period. SROI ratios were generated to determine the social value and cost savings associated per every $1AUD invested in cancer supportive care for both the healthcare system and patients. Deadweight, drop off and attribution were calculated, and sensitivity analysis was performed to confirm the stability of the model.

Results
The value generated from modelled supportive care service investments in a one-year period resulted in an SROI ratio of 1:9; that is, for every dollar invested in supportive care, AUD$9.00 social return is obtained when savings to the healthcare system and benefits to the patients are combined. At five-years, these same investments resulted in greater cumulative value generated for both the patient and the healthcare system, with a SROI ratio of 1:11.

Conclusion
Our study provides strong evidence for policy makers, clinicians and consumers to advocate for further investment in cancer supportive care, as demonstrated cost savings could be achieved through implementation of the proposed supportive care service model, with these accruing over a five-year period. The SROI model provides a comprehensive framework detailing supportive care services and the health workforce necessary to achieve value-based outcomes for patients and the healthcare system.
Identification of significant modules and hub genes involved in hepatic encephalopathy using WGCNA
Authors: Zhang Chihao , Luo Guqing , Lin Jiayun , Zhao Zhifeng , Luo Meng , Li Hongjie 
Published: November 2022

AbstractBackgroundHepatic encephalopathy (HE) is a reversible syndrome of brain dysfunction caused by advanced liver disease. Weighted gene co-expression network analysis (WGCNA) could establish a robust co-expression network to identify the hub genes and underlying biological functions. This study was aimed to explore the potential therapeutic targets in HE by WGCNA.ResultsThe green and brown modules were found to be significantly associated with the development of HE. Functional enrichment analyses suggested the neuroinflammation, neuroimmune, extracellular matrix (ECM), and coagulation cascade were involved in HE. CYBB and FOXO1 were calculated as hub genes, which were upregulated in the HE patients. Tamibarotene and vitamin E were suggested as possible drug candidates to alleviate HE.ConclusionsIt is the first time to analyze transcriptomic data of HE by WGCNA. Our study not only promoted the current understanding of neuroinflammation in HE, but also provided the first evidence that CYBB and FOXO1 played pivotal roles in the pathogenesis of HE, which might be potential biomarkers and therapeutic targets. Tamibarotene might be a novel drug compound against HE.
Strengthening futures-oriented agenda for building innovation ecosystems
Authors: Myllyoja Jouko , Rilla Nina , Lima-Toivanen Maria 
Published: November 2022

AbstractThis article locates itself at the interface of the innovation ecosystem approach and foresight methodologies. The need for writing this paper emerged from the notion that despite existing common praxis, there is a lack of academic studies combining these approaches simultaneously in a more profound sense. The study adapts the perspective of how foresight can assist in the development of innovation ecosystems. As a constructive study, the aim is to foster revealing the potential that foresight can have for the innovation ecosystem development in both theoretical and practical sense. Foresight approach and its methods offer anticipatory mindset and practical tools for developing and steering of ecosystem life cycle, keeping in mind that an ecosystem is not static but evolving system. For the foresight, the relevance of this article emerges from emphasising the viewpoint of stakeholders, which may generate wider and more engaged involvement of different stakeholders in foresight processes. As an outcome, the paper presents a model called the foresight wheel, which consists of three interrelated elements of ‘Thinking beyond immediate cooperating’, ‘Enabling continuous futures dialogue’ and ‘Building ecosystem futures’ capabilities’. The empirical reflection of this paper relies on observations achieved in an H2020-funded research project, in which both innovation ecosystems and foresight frameworks were applied as part of cybersecurity workshops organised in three Asian countries.
Sleep disruption as a potential contributor to the worsening of eating disorder pathology during the COVID-19-pandemic
Authors: Mehr Jacqueline B. , James Morgan H. 
Published: November 2022

AbstractThe acute phase of the COVID-19 pandemic was associated with significant increases in the prevalence and severity of eating disorders (EDs). Studies also highlighted changes to sleep quality and duration in many individuals throughout this period. Although these two phenomena have been examined separately, here we highlight the need to investigate the potential link between these outcomes. Sleep dysregulation and EDs have previously been hypothesized to interact via a positive feedback loop, wherein poor sleep exacerbates ED symptomatology which, in turn, further worsens sleep. Thus, we speculate that the aggravation of sleep disturbances and EDs during COVID-19 lockdowns may have been somewhat interdependent. We further hypothesize that the worsening of depression and anxiety symptomology during the acute phase of the pandemic may have served as an additional mediating variable. Altogether, in our view, these observations highlight a need for future work to examine the possible causal relationship between sleep and ED pathology, which may ultimately lead to improved clinical management of disordered eating.
Longitudinal measurement invariance of the Working Alliance Inventory - Short form across coaching sessions
Authors: Stefens Marjolein , Rondeel Eefje , Templin Jonathan , Brode David , de Waart Eddy , de Jong Rendel , ten Hoeve-Rozema Jacobien , Waringa Alexander , Reijnders Jennifer , Jacobs Nele , Lataster Johan 
Published: November 2022

AbstractBackgroundThroughout the psychotherapeutic and coaching literature, the client-therapist or coach-coachee working alliance has been highlighted as key force driving positive outcome. The Working Alliance Inventory Short form (WAI-S) for coaching charts the quality of working alliance throughout coaching sessions and is broadly applied in coaching research. Due to a shortfall in research on psychometric properties of the WAI-S, the purpose of this study was to examine (a) if the theorized three-factor structure of the 12-item WAI-S forms a solid representation of the dimensions of working alliance in coaching, and (b) longitudinal measurement invariance (LMI) of the WAI-S.MethodData were collected in a two-wave study design comprising a main study sample ofN = 690 Dutch coachees that completed the questionnaire at the first measurement, of whichN = 490 also completed the questionnaire at the second measurement. Post hoc sensitivity analysis was performed based on the original sample, lacking additional information on covariates, and included both completers and dropouts, comprisingN = 1986 respondents at T1, andN = 1020 respondents at T2.ResultsConfirmatory factor analyses evidenced best fit of the three-factor model in comparison to one-, and two-factor models at both time points. Despite the fact that multigroup confirmatory factor analysis detected non-invariant intercepts, our findings overall supported measurement invariance across coaching sessions.ConclusionsAs decisions in both clinical and scientific practices generally rely on outcome assessment of interpersonal change in scores on the same measure over time, we believe our findings to be of contributing value to the consolidation of interpretation and accuracy of scorings on the WAI-S in coaching.
Strategies to enhance CAR-T persistence
Authors: Liu Yue , An Lingna , Huang Ruihao , Xiong Jingkang , Yang Haoyu , Wang Xiaoqi , Zhang Xi 
Published: November 2022

Abstract
Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute lymphoblastic leukemia (B-ALL), although the primary response rate is promising, the high incidence of early relapse has caused modest long-term survival with CAR-T cell alone. One of the main challenges is the limited persistence of CAR-T cells. To further optimize the clinical effects of CAR-T cells, many studies have focused on modifying the CAR structure and regulating CAR-T cell differentiation. In this review, we focus on CAR-T cell persistence and summarize the latest progress and strategies adopted during the in vitro culture stage to optimize CAR-T immunotherapy by improving long-term persistence. Such strategies include choosing a suitable cell source, improving culture conditions, combining CAR-T cells with conventional drugs, and applying genetic manipulations, all of which may improve the survival of patients with hematologic malignancies by reducing the probability of recurrence after CAR-T cell infusion and provide clues for solid tumor CAR-T cell therapy development.
Healthier Lives Implementation Research Network for Māori and Pacific community health providers in Aotearoa New Zealand: a study protocol with an observational mixed methods design
Authors: Oetzel John , Sika-Paotonu Dianne , Penetito-Hemara Darrio , Henry Akarere 
Published: November 2022

Abstract
Background
Despite incremental gains in the Aotearoa New Zealand health sector, Māori and Pacific peoples still experience poorer health outcomes than non-Māori and non-Pacific. Access to the latest research and innovation is critical to improving and addressing health outcomes and health inequities in particular. However, there are numerous challenges to translating research into practice including that there is currently no known a specific infrastructure in Aotearoa New Zealand to facilitate this process. The aim of the project is to develop a network of community providers, researchers and health systems representatives that can help facilitate the implementation of novel and innovative programmes and products that help to meet the health needs of Māori and Pacific communities.

Methods
This project has three stages, one of which has been completed. In Stage 1, we engaged with key leaders of organisations from various components in the health system through a co-design process to identify parameters and infrastructure of the network. In Stage 2, we propose to construct the network involving approximately 20–30 community providers (and other affiliated researchers and health system representatives) and refine its parameters through an additional co-design process. Additionally, we will use a mixed methods research design using survey and interviews to identify perceived implementation needs, facilitators and barriers to help inform the work in the third stage. In Stage 3, we will support the active implementation of evidence-based programmes with a smaller number of providers (approximately four to eight community providers depending on the complexity of the implementation). Mixed methods research will be conducted to understand facilitators and barriers to implementation processes and outcomes.

Discussion
The proposed network infrastructure is an equity-oriented strategy focused on building capacity through a strength-based approach that can help address inequities over time. Our “proof-of-concept” study will not be able to change inequities in that time period given its relatively small scale and time period, but it should set the foundation for continued equity-oriented work.
Adaptation and implementation processes of a culture-centred community-based peer-education programme for older Māori
Authors: Simpson Mary Louisa , Ruru Stacey , Oetzel John , Meha Pare , Nock Sophie , Holmes Kathrine , Adams Hariata , Akapita Ngapera , Clark Marama , Ngaia Kawarau , Moses Reuben , Reddy Rangimahora , Hokowhitu Brendan 
Published: November 2022

Abstract
Background
Health inequities experienced by kaumātua (older Māori) in Aotearoa, New Zealand, are well documented. Examples of translating and adapting research into practice that identifies ways to help address such inequities are less evident. The study used the He Pikinga Waiora (HPW) implementation framework and the Consolidated Framework for Implementation Research (CFIR) to explore promising co-design and implementation practices in translating an evidence-based peer-education programme for older Māori to new communities.

Methods
The study was grounded in an Indigenous methodology (Kaupapa Māori) and a participatory research approach. Data were collected from research documentation, community meeting and briefing notes, and interviews with community researchers.

Results
The data analysis resulted in several key promising practices: Kaumātua mana motuhake (kaumātua independence and autonomy) where community researchers centred the needs of kaumātua in co-designing the programme with researchers; Whanaungatanga (relationships and connectedness) which illustrated how community researchers’ existing and emerging relationships with kaumātua, research partners, and each other facilitated the implementation process; and Whakaoti Rapanga (problem-solving) which centred on the joint problem-solving undertaken by the community and university researchers, particularly around safety issues. These results illustrate content, process, and relationship issues associated with implementation effectiveness.

Conclusions
This study showed that relational factors are central to the co-design process and also offers an example of a braided river, or He Awa Whiria, approach to implementation. The study offers a valuable case study in how to translate, adapt, and implement a research-based health programme to Indigenous community settings through co-design processes.

Trial registration
The project was registered on 6 March 2020 with the Australia New Zealand Clinical Trial Registry: ACTRN12620000316909. Prospectively registered.
Comparative study between one-stage versus three-stage repair of anorectal malformation with recto-vestibular fistula
Authors: Gad Mostafa , Farghaly Mohamed Ashraf , Abdullateef Khaled S. , Abdelazim Osama , Elfiky Mahmoud M. A. , Sattar Ayman Hussien A. , Kaddah Sherif Nabhan , Ragab Moutaz 
Published: November 2022

Abstract
Background
This is a retrospective comparative study that aimed to compare the short-term and intermediate-term outcomes of the one-stage and three-stage repair in the treatment of female neonates with a recto-vestibular fistula. Female patients who were presented with recto-vestibular fistula between 2017 and 2020 have been included in the study, and they were divided into two groups. Group A is the group of patients that underwent one-stage repair, and Group B is the group of patients that underwent three-stage repair. Short- and intermediate-term outcomes were recorded in both groups and the results were compared.

Results
Thirty-six female infants with recto-vestibular fistula were included in our study divided into two groups. Group A included 20 cases for whom we performed one-stage posterior sagittal anorectoplasty, and Group B also included 16 cases for whom the three-stage repair was done. The results showed that the three-stage repair had lower hospital stay (8 days) than the one-stage repair (15 days), and the three-stage repair has lower rates of wound infection, wound dehiscence, and recurrence than the one-stage repair.

Conclusion
The three-stage repair of anorectal malformations in females with recto-vestibular fistula is a safer technique, has lower rates of complications, and achieves comparable functional results to the one-stage repair.
Κατερίνα Μαριδάκη-Κασσωτάκη: In memoriam
Authors: Κόκκινος Κωνσταντίνος Μ. , Αντωνοπούλου Κατερίνα 
Published: November 2022

Το παρόν άρθρο αρχικά παρουσιάζει μια σύντομη περιγραφή των εργασιών που περιλαμβάνονται στο ειδικό αυτό αφιερωματικό τεύχος και συνεχίζει με την περιεκτική αναφορά στο έργο της Κατερίνας Μαριδάκη – Κασσωτάκη. Ακολούθως καταγράφει και συζητά τις τρέχουσες επιστημονικές εξελίξεις στο πεδίο της έρευνας για τη γονικότητα και την ανάπτυξη παιδιών και εφήβων, σε συνδυασμό με τα πορίσματα των ερευνητικών μελετών της Μαριδάκη-Κασσωτάκη ενσωματώνοντας ταυτόχρονα τα όσα προκύπτουν από τα άρθρα του ειδικού τεύχους.
Safety, quality, and nutritional aspect of smoked barracuda fish
Authors: Swastawati Fronthea , Riyadi Putut Har , Kurniasih Retno Ayu , Setiaputri Aninditya Artina , Sholehah Defita Faridlotus 
Published: November 2022

Background: Barracuda fish has a superior nutritional content, so it can be utilized as raw material for smoked fish products. The smoking method most commonly applied in Indonesia is traditional smoking. The traditional smoking process implemented commercially in Indonesia still uses simple equipment and sanitation is typically not monitored. Traditional smoking used at high temperatures can cause contamination of the products, such as with chemicals and microbes. Liquid smoke can be used to overcome these disadvantages. The study aimed to evaluate the nutritional, chemical, and microbial content of fresh and smoked barracuda processed using different smoking methods, namely traditional and liquid smoke. Methods: Barracuda fish were smoked using different smoking methods, traditional and liquid smoke. The traditional method used a simple smoking furnace, while the liquid smoke method was carried out by immersing the fish in a 5% liquid smoke solution. Then, the smoked barracuda were analyzed with various methods, such as proximate, heavy metals, histamine, benzo[a]pyrene, and total microbes (TPC). Data was analyzed using ANOVA at significance level (p < 0.05) followed by Duncan’s test models using SPSS v.16. Results: Smoked fish treated with liquid smoke had a lower value of Arsenic heavy metal (As), at 0.73 mg/kg compared to the traditional method at 1.93 mg/kg; no histamine and carcinogenic polycyclic aromatic hydrocarbon (PAH) compounds were detected, namely benzo[a]pyrene; and liquid smoked fish can inhibit the growth of bacteria which can be seen from total bacteria value of 4.6 x 10 colonies/g Conclusions: Smoked fish processed using a liquid smoke was safer for consumption by the consumer.
Evaluating the impact of Respiratory Syncytial Virus immunisation strategies on antibiotic use and drug resistant bacterial infections in England
Authors: Atkins Katherine E. , Hodgson David , Jit Mark , Davies Nicholas G. 
Published: November 2022

Background: Vaccines against viruses have been proposed as a novel means to reduce antibiotic use, which would, in turn, decrease selection for antibiotic resistant bacteria. However, the impact of this intervention is poorly quantified, and likely depends on setting-specific epidemiology. Therefore, with increasing confidence in a new vaccine against respiratory syncytial virus (RSV), it is important to quantify the impact of these vaccines on antibiotic prescribing and any downstream reduction in drug resistant bacterial infections. Methods: Here we integrate results from a dynamic transmission model of RSV and a statistical attribution framework to capture the impact of RSV vaccines on the reduction in antibiotic prescribing due to averted primary care visits in England. Results: Under base case assumptions, we find that the most impactful RSV vaccine strategy targets children aged 5–14 years, resulting in an annual reduction of 10.9 (8.0–14.2) antibiotic courses per 10,000 person years across the entire population, equivalent to reducing annual all-cause primary care prescribing by 0.23%. Our results suggest that this reduction in antibiotic use would gain 130 disability-adjusted life years and avert £51,000 associated with drug resistant bacterial infections. Seasonally administering monoclonal antibodies (mAbs) to high-risk infants under 6 months is the most efficient strategy, reducing per person year antibiotic prescribing by 2.6 (1.9–3.3) antibiotic courses per 1,000 mAb courses. Conclusions: Under optimistic conditions, the cost-effectiveness of RSV vaccine strategies in England would likely not be altered by integrating the benefits of preventing drug resistant infections in addition to RSV disease prevention.