bluuebunny/crossref_metadata_2025_split huggingface dataset:
A determination of the aerosolization efficiency of drugs of abuse in a eutectic mixture with nicotine in electronic cigarettes
Authors: Reveil Laerissa , Pearcy Adam C. , Povlick Jazmine , Poklis Justin L. , Halquist Matthew S. , Peace Michelle R. 
Published: July 2022

AbstractEutectic mixtures can be formed by adding drugs other than nicotine (DOTNs) to nicotine‐based e‐liquids in electronic cigarettes (e‐cigarettes). Thus, the interaction between nicotine e‐liquids and DOTNs must be evaluated. Presented is the change in e‐cigarette aerosolization of nicotine and methadone alone versus a 1:1 nicotine:methadone mixture to evaluate the possible formation of a eutectic mixture that can result in an increase of drug delivery. E‐liquids were prepared in‐house using 1:1 propylene glycol (PG):vegetable glycerin (VG) as a base plus nicotine, methadone hydrochloride, or 1:1 nicotine:methadone hydrochloride. The e‐liquids were aerosolized via an automated vaping machine using parameters adopted from the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) E‐cigarette Task Force method. Drug recovery was determined by capturing the aerosol from 15 puffs generated by the e‐cigarette. Concentrations of nicotine and methadone aerosolized were determined by gas chromatography–mass spectrometry using nicotine (n = 3), methadone (n = 3), and combined nicotine/methadone e‐liquids (n = 3), each prepared in‐house at 12 mg/ml. The concentration of nicotine and methadone in 15 puffs of the single drug e‐liquids were determined to be 1.60 ± 0.20 and 2.67 ± 0.12 mg, respectively. The concentration of nicotine and methadone in 15 puffs of the multidrug e‐liquid were determined to be 3.66 ± 0.49 and 3.65 ± 0.10 mg, respectively. The single nicotine and methadone e‐liquids had recoveries of 70 ± 0.1% and 84 ± 0.1%, respectively. In the 1:1 mixture, the recovery of both drugs increased. The development of a eutectic mixture can promote aerosolization of the drug and deliver a greater dose to the user.
Rigor and reproducibility for data analysis and design in the study of eating disorders
Authors: Susanin Annabel , Boyar Allison , Costello Kayla , Fraiman Annie , Misrok Arielle , Sears Malka , Hildebrandt Tom 
Published: July 2022

AbstractObjectiveIncorporating open science practices has become a priority for submission criteria in the International Journal of Eating Disorders (IJED). In this systematic review, we used the rigor and reproducibility framework developed by Hildebrandt and Prenoveau (2020) to examine the implementation of statistically sound open science principles in IJED, determining whether the cost and effort of incorporating these practices ultimately make research more likely to be cited.MethodFor this systematic review, six trained coders examined 1145 articles published from January 2011 to May 2021, including the 5 years prior to the 2016 introduction of the Open Science Foundation article preregistration. We coded for the presence or absence of 10 specific open science elements and calculated citation metrics for each article.ResultsThere was evidence of a significant positive relationship between time and total rigor and reproducibility (Total RR) criteria included in IJED articles following the implementation of preregistration in 2016. For every increase in year from 2011 to 2016, there was a .14 decrease in Total RR criteria. From 2016 to 2021, there was a .42 increase per volume in Total RR criteria. There was no statistically significant relationship between Total RR criteria and citation impact.DiscussionAlthough findings indicate that statistical rigor and reproducibility in this field has increased, the lack of direct relationship between open science methods and article visibility for scientists suggests that there is a limited incentive for researchers to participate in reporting guidelines.Public SignificanceStatistical controversies within science threaten the rigor and reproducibility of published research. Open science practices, including the preregistration of study hypotheses, links to statistical code, and explicit data‐sharing arguably generate reliable and valid inferences. This review illustrates the rigor and reproducibility of articles published in IJED between 2011 and 2021 and identifies whether open sciences practices have become increasingly prevalent in eating disorder research.
Do Nearctic hover flies (Diptera: Syrphidae) engage in long‐distance migration? An assessment of evidence and mechanisms
Authors: Clem C. Scott , Hobson Keith A. , Harmon‐Threatt Alexandra N. 
Published: July 2022

AbstractLong‐distance insect migration is poorly understood despite its tremendous ecological and economic importance. As a group, Nearctic hover flies (Diptera: Syrphidae: Syrphinae), which are crucial pollinators as adults and biological control agents as larvae, are almost entirely unrecognized as migratory despite examples of highly migratory behavior among several Palearctic species. Here, we examined evidence and mechanisms of migration for four hover fly species (Allograpta obliqua, Eupeodes americanus, Syrphus rectus, and Syrphus ribesii) common throughout eastern North America using stable hydrogen isotope (δ2H) measurements of chitinous tissue, morphological assessments, abundance estimations, and cold‐tolerance assays. Although further studies are needed, nonlocal isotopic values obtained from hover fly specimens collected in central Illinois support the existence of long‐distance fall migratory behavior in Eu. americanus, and to a lesser extent S. ribesii and S. rectus. Elevated abundance of Eu. americanus during the expected autumn migratory period further supports the existence of such behavior. Moreover, high phenotypic plasticity of morphology associated with dispersal coupled with significant differences between local and nonlocal specimens suggest that Eu. americanus exhibits a unique suite of morphological traits that decrease costs associated with long‐distance flight. Finally, compared with the ostensibly nonmigratory A. obliqua, Eu. americanus was less cold tolerant, a factor that may be associated with migratory behavior. Collectively, our findings imply that fall migration occurs in Nearctic hover flies, but we consider the methodological limitations of our study in addition to potential ecological and economic consequences of these novel findings.
Enantioselective Synthesis of 2,3,4,5‐Tetra(hydroxyalkyl)pyrrolidines through 1,3‐Dipolar Cycloadditions
Authors: Vardé Mariana , Marino Carla , Repetto Evangelina , Varela Oscar 
Published: July 2022

Abstract1,3‐Dipolar cycloadditions were conducted starting from azomethine ylides and enantiomerically pure sugar‐derived dihydropyranones. The ylide intermediates were generated from imines obtained by condensation of glycine or L‐alanine esters and 2,2‐dimethoxyacetaldehyde. This aldehyde was employed as precursor of a dimethoxymethyl group attached to the pyrrolidine ring, instead of the usual aryl group derived from aromatic aldehydes. Under silver catalysis the cycloaddition was highly regio‐ and diastereoselective, affording good yields of the 2,5‐cis cycloadducts, with the endo configuration strongly prevailing. The enantioselectivity was controlled by the acetal stereocenter of the pyranone: the (S)‐isomer gave a pyrrolidine with a defined configuration for the four asymmetric ring carbons, while the (R)‐dihydropyranone gave the enantiomeric ring. A sequence of reactions applied to the cycloadducts derived from (S)‐enone afforded the target 2,3,4,5‐tetra(hydroxyalkyl)pyrrolidines. The enantiomers were obtained from cycloadducts synthesized from the (R)‐enone. The pyrrolidines were evaluated as inhibitors of the β‐galactofuranosidase from Penicillium fellutanum.
Lifestyle behaviour in adolescence and musculoskeletal pain 11 years later: The Trøndelag Health Study
Authors: Smedbråten Kaja , Grotle Margreth , Jahre Henriette , Richardsen Kåre Rønn , Småstuen Milada Cvancarova , Skillgate Eva , Øiestad Britt Elin 
Published: July 2022

AbstractBackgroundThere is limited knowledge on the association between lifestyle behaviour in adolescence and musculoskeletal pain in young adulthood. This study aimed to investigate whether an accumulation of adverse lifestyle behaviours in adolescents with and without musculoskeletal pain at baseline, was associated with persistent musculoskeletal pain (pain duration ≥3 consecutive months the last year) 11 years later.MethodsLongitudinal data from the Trøndelag Health Study in Norway including 1824 adolescents (13–19 years old) was analysed. The outcome was persistent musculoskeletal pain (≥3 months). The number of adverse lifestyle behaviours (low physical activity level, sleep problems, insufficient fruit/vegetables consumption, smoking, frequent alcohol intoxication [drunkenness] and/or illicit drug use) were summed up to comprise an ordinal variable and analysed with 0 or 1 adverse behaviours as the reference. Multiple logistic regression analyses, stratified by individuals with and without baseline musculoskeletal pain, were conducted. The results were expressed as odds ratios (ORs) with 95% confidence intervals (CIs).ResultsIn adolescents with musculoskeletal pain at baseline, reporting ≥ four adverse lifestyle behaviours increased the odds of persistent musculoskeletal pain (OR 2.23, 95% CI 1.36, 3.66) 11 years later. Two and three adverse behaviours were not associated with future persistent musculoskeletal pain. In adolescents without musculoskeletal pain at baseline, an accumulation of adverse lifestyle behaviours was not associated with future persistent musculoskeletal pain.ConclusionAn accumulation of adverse lifestyle behaviours in adolescents with musculoskeletal pain at baseline was associated with persistent musculoskeletal pain 11 years later, but not in adolescents without musculoskeletal pain at baseline.SignificanceAn accumulation of four or more adverse lifestyle behaviours in adolescents with musculoskeletal pain was associated with persistent musculoskeletal pain in young adulthood. In future health care of adolescents with musculoskeletal pain, lifestyle behaviours should be assessed, with emphasis on accumulation of multiple adverse lifestyle behaviours. Focusing on an accumulation of multiple adverse lifestyle behaviours, rather than each individual behaviour, might provide a potential area for future research and interventions targeting musculoskeletal pain in youth.
Trees, large wood and streams: Using archive survey data to inform changing interactions in a human‐impacted landscape
Authors: Gurnell Angela M. , Hill Christopher T. , Davis Richard J. , Tooth Stephen 
Published: July 2022

AbstractMonitoring is the key to understanding fluvial systems and a crucial foundation for assessing the outcomes of river restoration. The New Forest, southern England, was designated a National Park in 2005 in recognition of its highly valued landscape, which has been both positively and negatively impacted by over 1000 years of human management. Here we analyse archive field maps and tabulations extracted from walkover surveys that record the distribution and character of wood jams along ~59 km of New Forest streams in 1991. By integrating the 1991 archive survey data with other historical information, we analyse associations among stream channel characteristics, wood jams, riparian land cover, and stream and land management at that time. We reveal associations among these factors that reflect the imprint of centuries of grazing, forestry and stream management practices. Along ~10 km of one stream (the Highland Water), we analyse data collected during additional walkover surveys in 1997 and 2021, to track changes since 1991. We illustrate how a reduction in stream and wood management over recent decades and the restoration of some stream reaches in 2005 has resulted in overall increases in stream sinuosity and the number of wood jams. The walkover surveys on which our results are based provide an approach to characterizing the impacts of river corridor management in the New Forest landscape that are both cost and time effective and could be applied by non‐specialist volunteers (‘citizen scientists’) following appropriate training. Survey data of the spatial coverage achieved in 1991 are rare but need to be encouraged in the New Forest and farther afield to provide a robust framework into which more local, specialist surveys can be integrated, and from which the broad impacts of river corridor management approaches can be monitored.
Functional, rheological, and microstructural properties of hydrothermal puffed and raw amaranth flour suspensions
Authors: Lux (neé Bantleon) Tanja , Kardell Martha , Reimold Frederike , Erdoes Adam , Floeter Eckhard 
Published: July 2022

AbstractThe pseudocereal amaranth is commonly used in food as whole puffed grain. To improve the utilization of amaranth, hydrothermally treated suspensions of puffed and raw Amaranthus caudatus flour and their blends were investigated in this study. The suspensions were hydrothermally treated at 20, 50, and 80°C for 1, 5, and 24 h. The blends were treated at 80°C for 1 h. The effect of hydrothermal treatments of the suspensions on their morphological (color, SEM), water‐binding, and rheological‐functional properties was studied. The puffed amaranth suspensions exhibited cold swelling properties by rapid viscosity increase and significant water absorption properties. It was found that hydrothermal treatment at 80°C for 1 h significantly increased water absorption and viscosity in puffed and raw flour suspensions. However, the puffed suspensions showed significantly higher values in water binding and viscosity. Suspensions of raw amaranth flour showed increasing color differences with increasing temperature. Blends of raw and puffed amaranth flour resulted in a decreasing color change with increasing puffed flour content. Water absorption of the samples increased with an increasing puffed flour content. Raw amaranth flour and the 50/50 (puffed/raw) blend had the lowest, 10/90 and 20/80 (puffed/raw), and showed similar viscosity profiles to suspensions of pure puffed flour.
Obesity and its associated factors among older adults: MyHEBAT (Malaysian HEalth and Well‐Being AssessmenT) study
Authors: Kyaw Thin Mon , Ismail Zaliha , Selamat Mohamad Ikhsan , Nawawi Hapizah ,   for the MyHEBAT investigators
Published: July 2022

AbstractBackgroundDespite being a preventable disease, the prevalence of obesity is rising progressively worldwide. However, the prevalence of obesity and its associated factors among older adults remains unclear in Malaysia. The aim of this study was to determine the prevalence of obesity and its associated factors among older adults who voluntarily attended the health screening programs, which were part of the Malaysian HEalth and Well‐Being AssessmenT (My‐HEBAT) Study.MethodsCross‐sectional study was conducted among Malaysian adults, aged ≥60 years. A standardized self‐administered questionnaire was used to gather information regarding socio‐demographic status, personal, family and medical history. Anthropometric indices, blood pressure and physical examinations were conducted on site. Venous blood samples were collected for lipid profile and blood glucose analysis. Participants with BMI of ≥30 kg/m2 or < 30kg/m2 were classified as obese or non‐obese respectively. Age was categorized into three subgroups: 60–69, 70–79, and ≥80 years old. The factors associated with obesity among older adults were then identified using multiple logistic regression.ResultsA total of 716 older adults aged ≥60 years (mean ± SD: 66.6 ± 6.0 years) were recruited. The prevalence of obesity among older adults was 15.8%, while higher prevalence was found among females (42.9%) compared to males (38.3%). The prevalence of obesity decreased with increasing age (48.5% in 60–69 years, 20.8% in 70–79 years, and 11.8% in ≥80 years).ConclusionThe prevalence of obesity among Malaysian population is higher than that of worldwide prevalence. Current national health promotion and educational programs should focus on identifying factors associated with obesity, and promotion of healthy lifestyle with obesity should be improved and modified, particularly for older adults in Malaysia.
Thermal performance of water‐based brines as a heat carrier for ground heat exchanger under severely cold environments
Authors: Verma Vikas , Tarodiya Rahul , Thangavel Sivasakthivel , Nath Ratnadeep 
Published: July 2022

AbstractThe aim of the present study is to investigate the performance of water‐based brine solutions in the ground heat exchanger (GHX) for space heating applications under severely cold climate conditions. The conventional ethylene glycol (EG) and propylene glycol (PG)‐based water solutions have been considered for investigation. For the closed‐loop vertical U‐tube GHX, a mathematically built model is developed for ambient temperature below 0°C. The thermal performance analysis of GHX is carried out for the variation in fluid flow rate and brine solutions for different mixture percentages of water in EG and PG. The percentage of the mixture and fluid flow rate varied from 25% to 60% and 0.2 to 0.6 LPS, respectively. GHX performance parameters, namely convective coefficient, pressure drop, borehole resistance, and GHX effectiveness are determined for both EG and PG brines. Better performance of GHX is noticed with EG brines as compared to PG brines for similar operating conditions. The drop in convective coefficient from 22% to 44% in the case of PG brines as compared to EG brines with the increase in mixture percentage from 25% to 60%, for the same operating conditions. The pressure drops decreased from 15% to 74% for EG mixture as compared to PG mixture at considered flow rate and mixture percentage. The effectiveness and overall borehole resistance were higher for EG as compared to the PG solution.
High‐dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression
Authors: Field David T. , Cracknell Rebekah O. , Eastwood Jessica R. , Scarfe Peter , Williams Claire M. , Zheng Ying , Tavassoli Teresa 
Published: July 2022

AbstractObjectiveVitamins B6 and B12 are involved in metabolic processes that decrease neural excitation and increase inhibition. This double‐blind study investigated the effects of supplementation for 1 month with a high‐dose of B6 or B12, compared to placebo, on a range of behavioural outcome measures connected to the balance between neural inhibition and excitation.Methods478 young adults were recruited over five linked phases. Self‐reported anxiety (N = 265) and depression (N = 146) were assessed at baseline and after supplementation. Several sensory measures acted as assays of inhibitory function and were assessed post‐supplementation only; these were surround suppression of visual contrast detection (N = 307), binocular rivalry reversal rate (N = 172), and a battery of tactile sensitivity tests (N = 180).ResultsVitamin B6 supplementation reduced self‐reported anxiety and induced a trend towards reduced depression, as well as increased surround suppression of visual contrast detection, but did not reliably influence the other outcome measures. Vitamin B12 supplementation produced trends towards changes in anxiety and visual processing.ConclusionsOur results suggest that high‐dose Vitamin B6 supplementation increases inhibitory GABAergic neural influences, which is consistent with its known role in the synthesis of GABA.
Sediment deposition characteristics in shallow saturation excess overland flow for urban Stormwater applications
Authors: Wells Jacqueline , Wilson Gregory 
Published: July 2022

AbstractOver the last several decades, urban stormwater management has grown to include green infrastructure, such as bioswales. However, little is known about the fate of particulate contaminants after depositing in bioswales and similar systems, in part due to limited understanding of sediment transport dynamics in the shallow (water depths comparable to bed roughness height), near‐saturated flow conditions typical of such systems. To better understand the sediment deposition characteristics, a flume study was performed with natural sediment and flow characteristics similar to those encountered in bioswales. A fluorescent, paramagnetic sediment tracer was used to mimic silt sized particles carried by stormwater flows, and a photographic hood was used to image the tracers deposited on the flume surface after subsequent pulses of tracer slurry, where the image intensity was established to be a reliable proxy for surface tracer concentration. These data were analysed to calculate the sediment trapping efficiency, that is, the rate of sediment deposition onto the soil surface per unit time, and samples of the flume effluent were collected to provide an independent mass balance of the deposited tracer. Experimentally determined sediment trapping efficiencies were found to decrease with increasing bed slope angle, which indicates soils at greater bed slopes will be less capable of retaining particulate‐associated contaminants, and were found to decrease over time as the soil surface became saturated with fine particles. These trapping efficiencies were also compared with mathematical models from the literature, augmented with a formula representing the observed surface‐saturation effect. The results of this study can lead to the development of more realistic models for predicting the removal performance of current stormwater remediation designs in regard to fine sediment associated contaminants.
NASICONs‐type solid‐state electrolytes: The history, physicochemical properties, and challenges
Authors: Zhang Lixiao , Liu Yimeng , You Ya , Vinu Ajayan , Mai Liqiang 
Published: July 2022

AbstractSolid‐state electrolytes are critical for the development of next‐generation high‐energy and high‐safety rechargeable batteries. Among all the candidates, sodium (Na) superionic conductors (NASICONs) are highly promising because of their evident advantages in high ionic conductivity and high chemical/electrochemical stability. The concept of NASICONs was proposed by Hong and Goodenough et al. in 1976 by reporting the synthesis and characterization of Na1+xZr2(SixP3−x)O12 (0 ≤ x ≤ 3), which has attracted tremendous attention on the NASICONs‐type solid‐state electrolytes. In this review, we are committed to describing the development history of NASICONs‐type solid‐state electrolytes and elucidating the contribution of Goodenough as a tribute to him. We summarize the correlations and differences between lithium‐based and sodium‐based NASICONs electrolytes, such as their preparation methods, structures, ionic conductivities, and the mechanisms of ion transportation. Critical challenges of NASICONs‐structured electrolytes are discussed, and several research directions are proposed to tackle the obstacles toward practical applications.
Bimodal polarization‐sensitive imaging and diffuse reflectance spectroscopy facilitated rapid augmented reality for tissue stratification
Authors: Hao Shicheng , Xiong Ying , Zheng Meng , Wang Jianfeng 
Published: July 2022

AbstractWe reported the development of a bimodal large field of view (~95 cm2) polarization‐sensitive (PS) imaging and point‐wise diffuse reflectance (DR) spectroscopy platform synergising the advantages of the two modalities. PS‐DR spectroscopy allows simultaneous label‐free biochemical and structural analysis of the investigated tissue. For real applications, the PS imaging first grossly stratified tissue into different categories, followed by high information dimension PS‐DR spectroscopy ascertaining ambiguous tissue regions identified by the PS imaging. Tested on a tissue phantom consisting of porcine esophagus muscularis propria and submucosa, it has demonstrated the system developed could complete tissue interrogation within 0.6 minutes and with separation accuracy of 95.87%. Further test on tissue phantom consisting of natural and crushed bovine tendon mimicking normal and cancerous breast tissues validated the potential of system developed to effectively and rapidly investigate large tissue area, facilitating augmented tissue boundary demarcation.