bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bedforms of Bonifacio Strait (Western Mediterranean): hydrodynamics, coastal outline, supply and sediment distribution
Authors: Deiana Giacomo , Demurtas Valentino , Orrù Paolo Emanuele 
Published: August 2022

Abstract
This paper shows the results of high-resolution survey on the continental shelf of Bonifacio Strait (north Sardinia). Multisensor and multiscale data obtained by means of sub-bottom profiler CHIRP and multibeam and side-scan sonar made it possible to identify the morphological features of bedforms. The analysis of both side-scan sonar sonograms mosaic and high-resolution seismic data allowed us to perform a detailed mapping of various substrates highlighting the presence of complex bedform associations. These bedform associations are typical of continental shelf environments affected by high-speed bottom currents. Multisource data analysis integrated by sedimentological study allowed us to identify the directions of sediment movements on the seabed and the progradation of bedforms. Locally, it was found that the bedforms of mobile bottoms are still active and they persist for more than a decade. The path of the currents’ circulation revealed that in the Bonifacio Strait, the bottom currents flow westwards, opposed to the prevailing sea surface flows.
UHPLC-MS/MS-Based Metabolomics and Clinical Phenotypes Analysis Reveal Broad-Scale Perturbations in Early Pregnancy Related to Gestational Diabetes Mellitus
Authors: Hu Ting , An Zhuoling , Li Han , Liu Yanping , Xia Liangyu , Qiu Ling , Yao Aimin , Ma Liangkun , Liu Lihong 
Published: August 2022

Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy, with adverse effects on both mother and fetus. The establishment of early diagnosis and risk assessment model is of great significance for preventing and reducing adverse outcomes of GDM. In this study, the broad-scale perturbations related to GDM were explored through the integration analysis of metabolic and clinical phenotypes. Maternal serum samples from the first trimester were collected for targeted metabolomics analysis by using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Statistical analysis was conducted based on the levels of the 184 metabolites and 76 clinical indicators from GDM women (

n

=60) and matched healthy controls (

n

=90). Metabolomics analysis revealed the down-regulation of fatty acid oxidation in the first trimester of GDM women, which was supposed to be related to the low serum level of dehydroepiandrosterone.While the significantly altered clinical phenotypes were mainly related to the increased risk of cardiovascular disease, abnormal iron metabolism, and inflammation. A phenotype panel established from the significantly changed serum indicators can be used for the early prediction of GDM, with the area under the receiver-operating characteristic curve (ROC) 0.83. High serum uric acid and C-reaction protein levels were risk factors for GDM independent of body mass indexes, with ORs 4.76 (95% CI: 2.08-10.90) and 3.10 (95% CI: 1.38-6.96), respectively. Predictive phenotype panel of GDM, together with the risk factors of GDM, will provide novel perspectives for the early clinical warning and diagnosis of GDM.
Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer
Authors: Nandi Ajeya , Debnath Rahul , Nayak Anupma , To Tsun Ki Jerrick , Thacker Gatha , Reilly Megan , Gumber Sanjeev , Karagounis Ilias , Li Ning , Lengner Christopher J. , Haldar Malay , Welm Alana L. , Blanco Andres M. , Thomas Christoforos , Chakrabarti Rumela 
Published: August 2022

AbstractResistance to radiotherapy is a major obstacle for effective cancer treatment. Both cancer-associated fibroblasts (CAF) within the tumor microenvironment (TME) and Notch signaling are implicated in radioresistance, but their potential interrelationship is unclear. Here, we report that irradiated samples obtained from luminal breast cancer patient tumors express higher levels of the Notch ligand Dll1 and have a greater number of αSMA- and FAP-expressing activated CAFs. Single cell transcriptomic profiles further revealed enrichment of an αSMA+ myofibroblastic subpopulation of CAF in Dll1+ tumors. In murine and human patient-derived xenograft models, Dll1+ tumor cells were more radioresistant than Dll1– tumor cells, and genetic and pharmacologic blocking of Dll1-mediated Notch signaling decreased the number of Dll1+ cancer stem cells (CSC) and CAFs and increased Dll1+ tumor cell radiosensitivity. Dll1+ cells recruited CAFs in an IL6-dependent fashion and promoted Wnt ligand secretion by Notch2/3-expressing CAFs, thereby driving Wnt/β-catenin–dependent increases in Dll1+ CSC function to promote metastasis. Treatment with the porcupine inhibitor LGK-974 that inhibits Wnt ligand secretion or pharmacologic blockade of IL6 or Dll1 suppressed CAF-dependent enhancement of Dll1+ CSC function and metastasis in radioresistant tumors. Together, these findings reveal an essential cross-talk between Dll1+ cancer cells and CAFs, which promotes metastasis and radioresistance, which could be therapeutically exploited to improve the outcome of patients with breast cancer.Significance:Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin–driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.
Pathway-based Approach Reveals Differential Sensitivity to E2F1 Inhibition in Glioblastoma
Authors: Alvarado Alvaro G. , Tessema Kaleab , Muthukrishnan Sree Deepthi , Sober Mackenzie , Kawaguchi Riki , Laks Dan R. , Bhaduri Aparna , Swarup Vivek , Nathanson David A. , Geschwind Daniel H. , Goldman Steven A. , Kornblum Harley I. 
Published: August 2022

Analysis of tumor gene expression is an important approach for the classification and identification of therapeutic vulnerabilities. However, targeting glioblastoma (GBM) based on molecular subtyping has not yet translated into successful therapies. Here, we present an integrative approach based on molecular pathways to expose new potentially actionable targets. We used gene set enrichment analysis to conduct an unsupervised clustering analysis to condense the gene expression data from bulk patient samples and patient-derived gliomasphere lines into new gene signatures. We identified key targets that are predicted to be differentially activated between tumors and were functionally validated in a library of gliomasphere cultures. Resultant cluster-specific gene signatures associated not only with hallmarks of cell cycle and stemness gene expression, but also with cell type–specific markers and different cellular states of GBM. Several upstream regulators, such as PIK3R1 and EBF1 were differentially enriched in cells bearing stem cell like signatures and bear further investigation. We identified the transcription factor E2F1 as a key regulator of tumor cell proliferation and self-renewal in only a subset of gliomasphere cultures predicted to be E2F1 signaling dependent. Our in vivo work also validated the functional significance of E2F1 in tumor formation capacity in the predicted samples. E2F1 inhibition also differentially sensitized E2F1-dependent gliomasphere cultures to radiation treatment. Our findings indicate that this novel approach exploring cancer pathways highlights key therapeutic vulnerabilities for targeting GBM.Significance:Molecular classification of GBM has not yet resulted in the development of effective therapies. We have developed an integrative approach to identify molecular targets differentially utilized by individual tumors. This approach could lead to patient- and tumor-specific therapeutics.
Topographical distribution of the human brain to Plukenetia volubilis-based omega-3,6,9 enriched egg consumption
Authors: Sittiprapaporn Phakkharawat , Suyajai Prayoon 
Published: August 2022

<span>Docosahexaenoic acid (DHA) is related to cognitive development. Consumers' brain health could benefit from changes in the omega 6:3 ratio. This study aimed to examine how the </span><em><span>Plukenetia volubilis</span></em><span>-based omega-3,6,9 enriched egg supplementation affects electrical brain activity during the attention/inhibition (Go/NoGo) test. Healthy subjects (n = 20) were chosen at random to eat 2 boiled </span><em><span>Plukenetia volubilis</span></em><span>-based omega-3,6,9 enriched eggs for 12 weeks. The ePrime v.3.0 application recorded behavioral performance during the Go/NoGo test during the electroencephalographic recording. The finding of this study was that twelve weeks of boiled </span><em><span>Plukenetia volubilis</span></em><span>-based omega-3,6,9 enriched egg consumption significantly decreased the reaction time responses compared to the baseline. The topographical distribution revealed that the mean amplitude of N1 produced a slightly larger amplitude in the 12<sup>th</sup> week compared to the baseline. The P3 component, following N1, was also larger in the 12<sup>th</sup> week compared to the baseline. After 12 weeks of consuming the </span><em><span>Plukenetia volubilis</span></em><span>-based omega-3,6,9 enriched eggs, the central nervous system activities during a Go/NoGo test were believed to be enhanced. </span>
Classification technique for real-time emotion detection using machine learning models
Authors: Sawangwong Chanathip , Puangsuwan Kritsada , Boonnam Nathaphon , Kajornkasirat Siriwan , Srisang Wacharapong 
Published: August 2022

<span>This study aimed to explore models to identify a human by using face recognition techniques. Data were collected from Cohn-Kanade dataset composed of 398 photos having face emotion labeled with eight emotions (i.e., neutral, angry, disgusted, fearful, happy, sad, and surprised). Multi-layer perceptron (MLP), support vector machine (SVM), and random forest were used in model accuracy comparisons. Model validation and evaluation were performed using Python programming. The results on F1 scores for each class in the dataset revealed that predictive classifiers do not perform well for some classes. The support vector machine (RBF kernel) and random forest showed the highest accuracies in both datasets. The results could be used to extract and identify emotional expressions from the Cohn-Kanade dataset. Furthermore, the approach could be applied in other contexts to enhance monitoring activities or facial assessments. </span>
Machine learning based chroma phase offset detection and correction in motion video
Authors: Mogre Advait , Madnani Shekhar 
Published: August 2022

<span lang="EN-US">Generally, chroma phase or hue offset issues within a scene are hard to detect, without a reference or context (i.e. some apriori<em> </em>knowledge about how certain objects within the scene should actually<em> </em>appear in terms of their hue). Moreover, when it comes to skin/flesh tones, hue deviation can be noticeable and can markedly degrade the viewer quality of experience</span><span lang="IN">(QoE)</span><span lang="EN-US">, whenever it does occur. However a lot of research has gone into flesh tone detection, specifically, the color gamut within which flesh tone is present. This topic has been well documented in the literature with respect to various color spaces: red, green, blue (RGB) and YIQ. Therefore, overall issues with chroma offset or hue within the video content could potentially be approached by extracting and analyzing a reliable reference, such as skin or flesh tone (if present), within some allowable deviation. This involves machine learning (ML) based facial recognition and tracking followed by skin tone region recognition within the detected facial sequence (i.e. Region of Interest). The skin region serves as a ‘self-reference’ in order to discern any inherent phase offset within the content. Finally, the angular chroma deviation discerned can then be used for subsequent correction as well.</span><p> </p>
The Average Reward Rate Modulates Behavioral and Neural Indices of Effortful Control Allocation
Authors: Lin Hause , Ristic Jelena , Inzlicht Michael , Otto A. Ross 
Published: August 2022

Abstract
People tend to avoid exerting cognitive effort, and findings from recent behavioral studies suggest that effort allocation is in part determined by the opportunity cost of slothful responding—operationalized as the average reward rate per unit time. When the average rate of reward is high, individuals make more errors in cognitive control tasks, presumably owing to a withdrawal of costly cognitive processing. An open question remains whether the presumed modulations of cognitively effortful control processes are observable at the neural level. Here, we measured EEG while participants completed the Simon task, a well-known response conflict task, while the experienced average reward rate fluctuated across trials. We examined neural activity associated with the opportunity cost of time by applying generalized eigendecomposition, a hypothesis-driven source separation technique, to identify a midfrontal component associated with the average reward rate. Fluctuations in average reward rate modulated not only component amplitude but also, most importantly, component theta power (4–8 Hz). Higher average reward rate was associated with reduced theta power, suggesting that the opportunity of time modulates effort allocation. These neural results provide evidence for the idea that people strategically modulate the amount of cognitive effort they exert based on the opportunity cost of time.
Overton: A bibliometric database of policy document citations
Authors: Szomszor Martin , Adie Euan 
Published: August 2022

Abstract
This paper presents an analysis of the Overton policy document database, describing the makeup of materials indexed and the nature in which they cite academic literature. We report on various aspects of the data, including growth, geographic spread, language representation, the range of policy source types included, and the availability of citation links in documents. Longitudinal analysis over established journal category schemes is used to reveal the scale and disciplinary focus of citations and determine the feasibility of developing field-normalized citation indicators. To corroborate the data indexed, we also examine how well self-reported funding outcomes collected by UK funders correspond to data indexed in the Overton database. Finally, to test the data in an experimental setting, we assess whether peer-review assessment of impact as measured by the UK Research Excellence Framework (REF) 2014 correlates with derived policy citation metrics. Our findings show that for some research topics, such as health, economics, social care, and the environment, Overton contains a core set of policy documents with sufficient citation linkage to academic literature to support various citation analyses that may be informative in research evaluation, impact assessment, and policy review.
Introduction: Approaching Gender and Ministries of Foreign Affairs
Authors: Niklasson Birgitta , Towns Ann E. 
Published: August 2022

Abstract
This introductory article situates Ministries of Foreign Affairs (MFAs) as gendered institutions at the intersection between domestic and international relations. Based on an extensive literature review and analysis of articles on Australian, Bulgarian, Czech, Japanese, Turkish, UK, and US MFAs in this special issue, we claim that research on gender and MFAs has made important contributions to diplomatic studies by deepening, challenging, and diversifying understandings of what MFAs are; MFAs’ institutional structures; and power struggles within MFAs. MFA relations with other actors remain decidedly understudied from a gender perspective, however. Future research on gender and MFAs should direct attention to these relationships, including how they shape MFAs as gendered institutions. Future studies would also benefit from global and intersectional analyses of multiple axes of power and differentiation. By identifying research questions, new theoretical perspectives, and largely unapplied research designs, we hope to facilitate the pursuit of such studies.
Law of the Excluded Middle and Beckett’s Realm of Neitherness
Authors: Shehzad Umar 
Published: August 2022

Abstract
This study traces the play of thresholds in Beckett’s short text “neither”. Since its publication in 1976, the text has been haunted by its thematic indeterminacy. Originally published as a poem, it was gathered with other pieces of short prose on Beckett’s suggestion when he insisted that it was a short story. The protagonist (though it is too strong a term to be used in the present context) finds themself before the mobile gates of the neitherworld “whose doors once neared gently close/once turned away from gently part again”. Beckett’s text creates a paradigmatic limbo, a non-space tussling with the ghosts of being. The movement is not, as Garin Dowd contends, “from its presence to its absence, from its being to non-being, from its formation to its emptying”; the beingness of being is already reduced to shadows. The reflex of opening and closure, the subject of the text, is further displaced on to the door, effectively quashing the potency of human agency. The door here is the reality of being. The effigy of a person is left stranded on the in-between spaces. This inbetweenness is located on the site of excluded middle—a site considered untenable in the classical logic. Moreover, the study looks at the ontological praxis of this inbetweenness.
La politique de l’intime
Authors: Lecossois Hélène 
Published: August 2022

Résumé
Cet article propose une lecture de Oh les beaux jours (1963) et Comédie (1964) au prisme du contexte historique de leur création (modernisation accélérée, retrait dans la sphère privée, effritement de l’empire colonial français) et s’intéresse à l’intersection de l’intime et du politique. Le télescopage du salon bourgeois et de l’empire que les pièces donnent à voir invite à appréhender la métropole et les colonies non pas comme des lieux séparés, tels qu’ils furent construits, mais comme des lieux contigus et met en lumière la nature fondamentalement politique de la sphère domestique ainsi que les liens qui l’unissent à une idéologie de la domination.
Characteristics of HIV/sexually transmitted infections among men who have sex with men and women in Bangkok, Thailand
Authors: Chaiyabutr Chayada , Nanchaipruek Yanisorn , Pochanapan Oraya , Leeyaphan Charussri , Jiamton Sukhum 
Published: August 2022

Background Men who have sex with men (MSM) are a key HIV target population in Thailand. An important subgroup is men who have sex with men and women (MSMW) as they can sexually transmit infections between individuals with different gender identities. This study compared the sexually transmitted infection risk behavior of different types of men in Thailand. Methods We retrospectively reviewed the medical records of 839 consecutive male patients who visited an STI clinic in Bangkok, Thailand, between 2014 and 2020. Results Men who have sex with women only (MSWO) predominated (58.0%), followed by men who have sex with men only (MSMO, 32.2%) and MSMW (9.8%). MSMW and MSMO shared similar sexual risk behaviors, such as significantly higher median numbers of sex partners (10 and 8, respectively) than MSWO (5; Kruskal–Wallis, p < 0.001). MSMW had the highest prevalence of concurrent sexual partnerships (91.4%), significantly different from MSWO (61.2%) and MSMO (76.7%; chi-squared, p < 0.001). HIV and syphilis prevalence was significantly higher for MSMO (48.9% and 51.1%) and MSMW (42.7% and 48.8%) than MSWO (12.3% and 20.9%; chi-squared, p < 0.001). Conclusions MSMW exhibited similar sexual risk behavior and high HIV/STI prevalence comparable to MSMO.
Maribavir for the Management of Cytomegalovirus in Adult Transplant Recipients: A Review of the Literature and Practical Considerations
Authors: Kleiboeker Hanna L. , Descourouez Jillian L. , Schulz Lucas T. , Mandelbrot Didier A. , Odorico Jon S. , Rice John P. , Saddler Christopher M. , Smith Jeannina A. , Jorgenson Margaret R. 
Published: August 2022

Objective: To review the efficacy and safety of maribavir for management of cytomegalovirus (CMV) in solid organ transplant recipients. Data Sources: A literature search of PubMed and the Cochrane Controlled Trials Register (1960 to early July 2022) was performed using the following search terms: maribavir, 1263W94, and cytomegalovirus. Study Selection and Data Extraction: All relevant English-language studies were reviewed and considered, with a focus on phase 3 trials. Data Synthesis: Maribavir, an orally available benzimidazole riboside with minimal adverse effects, was originally studied for universal prophylaxis in phase 3 trials but failed to demonstrate noninferiority over placebo and oral ganciclovir. It was effective for preemptive treatment in a dose-finding Phase 2 study. Maribavir is FDA approved for treatment of refractory/resistant CMV infection based on improved response rate at 8 weeks compared with investigator-assigned therapy (IAT) when initiated at median viral loads less than approximately 10 000 IU/mL (55.7% vs 23.9%, P < 0.001). Recurrence after 8-week treatment for refractory/resistant CMV was high (maribavir 50% vs IAT 39%). Significant drug interactions exist and must be managed by a pharmacotherapy expert to prevent harm. Relevance to Patient Care and Clinical Practice: The addition of maribavir to the antiviral armamentarium should improve the management of refractory/resistant CMV, allowing early transition from toxic, high-cost, intravenous agents such as foscarnet and outpatient management. Optimal timing of initiation, duration, and potential alternative uses are unclear. Conclusion: Future studies are needed to fully elucidate the role of maribavir in the management of CMV after transplant.
Infertility In Queens: Clinical approach, experiences and challenges
Authors: Fontbonne Alain 
Published: August 2022

Clinical challenges: It is not easy for a veterinarian to determine the cause of infertility in a queen. The simplest method is to start by investigating the most common causes and then progress by successive elimination to the less common causes. For example, mating problems are commonly responsible for reproductive failure, and owners should be particularly vigilant in checking that the mating is progressing satisfactorily. Frequently, a veterinarian may have to determine, among other things, if there is a uterine or hormonal disorder or if an infectious pathology may be involved. In the case of a queen that is not cycling, it is important to differentiate a lack of onset of puberty in a young queen from a lack of cyclicity in an adult queen. Aim: This review sets out a practical, step-by-step approach that veterinarians can follow, starting with the most common causes of infertility in queens and moving towards more rare or specific causes. Equipment and technical skills: Simple techniques such as vaginal smears are essential to determine if a queen that is ready to be mated is in full oestrus, if a queen is cycling or not and to diagnose inflammation of the genital tract. Veterinarians should be familiar with the peculiarities of the swabbing technique in cats, as well as the interpretation of feline vaginal cytology. Progesterone assays are useful on many occasions in the diagnosis pathway. A laboratory capable of performing karyotypes should ideally be available. Finally, it is important to be able to perform an ultrasound examination of the ovaries and uterus in a queen. Evidence base: Although it appears that infertility is a problem among purebred queens, there is a lack of knowledge in this area and too few published studies. Some causes of feline infertility remain poorly investigated.