bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mercenaries, Migration and the Crew of the Mary Rose
Authors: NELSON SAMANTHA , FLETCHER CATHERINE 
Published: October 2022

AbstractThis article reconsiders the presence of foreigners in the crew of Henry VIII's ship the Mary Rose in light of recent archaeological investigations of human remains from the wreck. Through an interdisciplinary analysis drawing on archaeological investigation, the artefacts found on board the Mary Rose and historical documents, this study investigates the context for the presence of foreigners on board the ship, considering how and why these men came to be on board an English warship during the mid‐Tudor period. Although media coverage extrapolated from recent archaeological research an image of a multicultural England, this study argues that the challenge to the narrative of Henrician England as ethnically homogenous should also be considered alongside military contexts. In particular, by framing the source material within the context of both short‐term military‐based and longer‐term patterns of migration, this study points to the importance of considering military factors, the wider picture of migration, and, in particular, the intersection between them. Furthermore, it demonstrates that Tudor England relied on foreign soldiers, trade, labour and skills. By placing the archaeological and scientific enquiries into their historical contexts, a more complete narrative of Henrician England can be formed – one that acknowledges the role of strangers and transnational relationships in the defence and maintenance of the English realm.
Unmet needs for food, medicine, and mental health services among vulnerable older adults during the COVID‐19 pandemic
Authors: Tai‐Seale Ming , Cheung Michael W. , Kwak Jamie , Harris Victoria , Madonis Samantha , Russell Lc , Haley Eileen , Agnihotri Parag 
Published: October 2022

AbstractObjectiveTo examine sociodemographic factors associated with having unmet needs in medications, mental health, and food security among older adults during the COVID‐19 pandemic.Data Sources and Study SettingPrimary data and secondary data from the electronic health records (EHR) in an age‐friendly academic health system in 2020 were used.Study DesignObservational study examining factors associated with having unmet needs in medications, food, and mental health.Data Collecting/Extraction MethodsData from a computer‐assisted telephone interview and EHR on community‐dwelling older patients were analyzed.Principle FindingsAmong 3400 eligible patients, 1921 (53.3%) (average age 76, SD 11) responded, with 857 (45%) of respondents having at least one unmet need. Unmet needs for medications were present in 595 (31.0%), for food in 196 (10.2%), and for mental health services in 292 (15.2%). Racial minorities had significantly higher probabilities of having unmet needs for medicine and food, and of being referred for services related to medications, food, and mental health. Patients living in more resource‐limited neighborhoods had a higher probability of being referred for mental health services.ConclusionsAge‐friendly health systems (AFHS) and their recognition should include assessing and addressing social risk factors among older adults. Proactive efforts to address unmet needs should be integral to AFHS.
The impact of Medicare shared savings program participation on hospital financial performance: An event‐study analysis
Authors: Huang Huang , Zhu Xi , Ullrich Fred , MacKinney A. Clinton , Mueller Keith 
Published: October 2022

AbstractObjectiveTo evaluate the impact of hospitals' participation in the Medicare Shared Savings Program (MSSP) on their financial performance.Data SourcesCenters for Medicare & Medicaid Services Hospital Cost Reports and MSSP Accountable Care Organizations (ACO) Provider‐Level Research Identifiable File from 2011 to 2018.Study DesignWe used an event‐study design to estimate the temporal effects of MSSP participation on hospital financial outcomes and compared within‐hospital changes over time between MSSP and non‐MSSP hospitals while controlling for hospital and year fixed effects and organizational and service‐area characteristics. The following financial outcomes were evaluated: outpatient revenue, inpatient revenue, net patient revenue, Medicare revenue, operating margin, inpatient revenue share, Medicare revenue share, and allowance and discount rate.Data Collection/Extraction MethodsSecondary data linked at the hospital level.Principal FindingsControlling for trends in non‐MSSP hospitals, MSSP participation was associated with differential increases in net patient revenue by $3.28 million (p < 0.001), $3.20 million (p < 0.01), and $4.20 million (p < 0.01) in the second, third, and fourth year and beyond after joining MSSP, respectively. Medicare revenue differentially increased by $1.50 million (p < 0.05), $2.24 million (p < 0.05), and $4.47 million (p < 0.05) in the first, second, and fourth year and beyond. Inpatient revenue share differentially increased by 0.29% (p < 0.05) in the second year and 0.44% (p < 0.05) in the fourth year and beyond. Medicare revenue share differentially increased by 0.17% (p < 0.01), 0.25% (p < 0.01), 0.32% (p < 0.01), and 0.41% (p < 0.01) in consecutive years following MSSP participation. MSSP participation was associated with 0.33% (p < 0.05) and 0.39% (p < 0.05) differential reduction in allowance and discount rate in the second and third years.ConclusionsMSSP participation was associated with differential increases in net patient revenue, Medicare revenue, inpatient revenue share, and Medicare revenue share, and a differential reduction in allowance and discount rate.
Research on traceability strategy of food supply chain considering delay effect
Authors: Zhou Yan‐Ping , Zhao Xiao‐Jie , Sun Lu 
Published: October 2022

AbstractThe traceability system has significantly contributed to ensure food safety and quality. However, the biggest difficulty in food traceability is the numerous links from field to table, and there is no stable strategic partnership between supply chain members and the lack of social responsibility of some practitioners. Thus, this study aims to seek the best traceability strategy for companies in centralized model and decentralized model, respectively. Therefore, we have constructed a differential game model based on the delay effect to determine the optimal traceability level and traceable goodwill and compare the profits of the food supply chain (FSC). The results show that the delay time is positively related to the level of traceability effort and has a high impact on the traceable goodwill. Companies in the FSC can formulate optimal traceability strategies based on delay time and foster improvement in food safety and quality.
Influence of landscape and connectivity on anuran conservation: population viability analyses to designate protected areas
Authors: Andersen D. , Jang Y. , Borzée A. 
Published: October 2022

AbstractThreatened species with restricted ranges are at risk from habitat fragmentation and loss, which amplifies genetic bottleneck and impacts of small changes to their environments. Ecological models including population viability analyses (PVAs) can predict the trajectory of populations in a way that is not invasive or detrimental to the study species. They can therefore be a vital tool in modeling populations for conservation purposes. Although habitat suitability models have been used in studies to suggest areas for protected area designation, PVAs are generally not used in this regard.Dryophytes suweonensisandDryophytes flaviventrisare two threatened treefrog species endemic to the Korean Peninsula. The two species face threats of habitat loss and degradation and predation by invasive species among others. We used an integrated modeling approach combining ecological niche, connectivity, and PVAs in Vortex to determine the likelihood of extinction of each species under baseline and protected area designation scenarios. Designation scenarios were simulated in Vortex through halting future reduction in carrying capacity (halting future degradation to sites through protected area status), reducing effects of catastrophes (mitigating the effects of drought), and reducing mortality rates (controlling invasive predator populations and ex situ raising of tadpoles to maturity). We classified the combination of these management efforts as “active management” as opposed to “no management,” which is currently being practiced. We additionally used a stepwise approach to determine designation priority of individual patches. Under current conditions (no management), the resulting effective metapopulations after 100 years were 167 ± 325 individuals with an 86.5% extinction probability forD. suweonensisand 165 ± 200 individuals with a 90.3% extinction probability forD. flaviventris. Under active management of all sites (93 sites covering 426.9 km2), the extinction probability was 0% for both species with significantly increased metapopulation sizes, 15 910 ± 2855 forD. suweonensis, and 4400 ± 874 forD. flaviventris. Determining designation priority can inform the regulatory bodies on which habitat to designate and whether active or passive management should be applied. Without intervention, these species will be likely to face imminent extinction. In addition to being useful for government‐imposed conservation management, our study can be followed by future studies as a methodology for prioritizing sites for protected area designation.
Commentary: Improving access to cardiac rehabilitation (Heart: Road for health) for Aboriginal and Torres Strait Islander peoples in rural and remote areas of North Queensland
Authors: Field Patricia , Franklin Richard C. , Barker Ruth , Ring Ian , Leggat Peter , Canuto Karla 
Published: October 2022

AbstractAimsTo focus on the needs, challenges and opportunities to improve access to cardiac rehabilitation (CR) (Heart: Road to health [HRH]) for Aboriginal and Torres Strait Islander peoples in rural and remote (R&R) areas of North Queensland.ContextIt is known that there is insufficient access to HRH for Aboriginal and Torres Strait Islander peoples in R&R areas of NQ, who have the highest rates of heart disease and socioeconomic disadvantage mainly due to poor social determinants of health. However, at least in part due to the impact of colonialism and predominantly western medicalised approach to health care, few gains have been made.ApproachThis commentary draws on recent research and literature and reflects on cultural issues that impact on improving access to an HRH for Aboriginal and Torres Strait Islander peoples in R&R areas. The underutilisation of the skills of Aboriginal and Torres Strait Islander Health Workers (ATSIHW) and a lack of a defined process to ensure access to culturally responsive HRH are discussed. Finally, a way forward is proposed that includes the development of policies, pathways and guidelines to ensure that appropriate support is available in the client's home community.ConclusionIt is proposed that culturally responsive, accessible and effective HRH is achievable through the reorientation of current health systems that include a continuous client‐centred pathway from hospital to home. In this model, ATSIHW will take a lead or partnership role in which their clinical, cultural brokerage and health promotion skills are fully utilised.
Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice
Authors: Poli Aurélie , Oudin Anaïs , Muller Arnaud , Salvato Ilaria , Scafidi Andrea , Hunewald Oliver , Domingues Olivia , Nazarov Petr V. , Puard Vincent , Baus Virginie , Azuaje Francisco , Dittmar Gunnar , Zimmer Jacques , Michel Tatiana , Michelucci Alessandro , Niclou Simone P. , Ollert Markus 
Published: October 2022

AbstractBackgroundNumerous patient‐based studies have highlighted the protective role of immunoglobulin E‐mediated allergic diseases on glioblastoma (GBM) susceptibility and prognosis. However, the mechanisms behind this observation remain elusive. Our objective was to establish a preclinical model able to recapitulate this phenomenon and investigate the role of immunity underlying such protection.MethodsAn immunocompetent mouse model of allergic airway inflammation (AAI) was initiated before intracranial implantation of mouse GBM cells (GL261). RAG1‐KO mice served to assess tumor growth in a model deficient for adaptive immunity. Tumor development was monitored by MRI. Microglia were isolated for functional analyses and RNA‐sequencing. Peripheral as well as tumor‐associated immune cells were characterized by flow cytometry. The impact of allergy‐related microglial genes on patient survival was analyzed by Cox regression using publicly available datasets.ResultsWe found that allergy establishment in mice delayed tumor engraftment in the brain and reduced tumor growth resulting in increased mouse survival. AAI induced a transcriptional reprogramming of microglia towards a pro‐inflammatory‐like state, uncovering a microglia gene signature, which correlated with limited local immunosuppression in glioma patients. AAI increased effector memory T‐cells in the circulation as well as tumor‐infiltrating CD4+T‐cells. The survival benefit conferred by AAI was lost in mice devoid of adaptive immunity.ConclusionOur results demonstrate that AAI limits both tumor take and progression in mice, providing a preclinical model to study the impact of allergy on GBM susceptibility and prognosis, respectively. We identify a potentiation of local and adaptive systemic immunity, suggesting a reciprocal crosstalk that orchestrates allergy‐induced immune protection against GBM.
Comprehensive assessment of genetic diversity, structure, and relationship in four Japanese cattle breeds by Illumina 50 K SNP array analysis
Authors: Kawaguchi Fuki , Nakamura Mitsuki , Kobayashi Eiji , Yonezawa Takahiro , Sasazaki Shinji , Mannen Hideyuki 
Published: October 2022

AbstractThere are four unique cattle breeds in Japan: Japanese Black, Japanese Brown, Japanese Polled, and Japanese Shorthorn. The objective of this study was to comprehensively assess the genetic diversity, structure, relationship, and the degree of influence from foreign breeds (Angus, Simmental, Hanwoo, Shorthorn, Ayrshire, Brown Swiss, and Devon) in the Japanese cattle breeds using Illumina 50 K SNP array. In principal component analysis, each Japanese breed was separately clustered except for Japanese Shorthorn and Shorthorn. Japanese cattle breeds also showed different genetic components from each other at K ≥ 5 in population structure analysis. Japanese Shorthorn, on the other hand, had a very similar structure to Shorthorn at K ≤ 9, and Japanese Polled had a partially similar component with Angus at K = 3–7. Such close relationships were also observed in the phylogenetic tree. These findings imply that Japanese cattle breeds share genetic components with European cattle breeds to some extent while they have been almost differentiated. In population structure analysis, Japanese Black cattle shared little genetic component (3.5%) with European breeds. This is the first study to determine the extent to which European breeds impact Japanese breeds.
In the moment social experiences and perceptions of children with social anxiety disorder: A qualitative study
Authors: Halldorsson Brynjar , Waite Polly , Harvey Kate , Pearcey Samantha , Creswell Cathy 
Published: October 2022

AbstractObjectivesChildhood social anxiety disorder (SAD) is a common and disabling condition. General forms of cognitive behavioural treatments have demonstrated poorer efficacy for childhood SAD when compared to other childhood anxiety disorders and further understanding of the psychological factors that contribute to the maintenance of childhood SAD is warranted. Examining the social experiences of children with SAD may help to identify relevant psychological factors and increase our understanding of what keeps childhood SAD going.MethodsThe current study used reflexive thematic analysis to analyse the transcripts of interviews with 12 children aged 8–12 years with SAD who had been interviewed about their ‘in the moment’ social experiences during a social stress induction task. The interview topic guide included factors hypothesized to maintain SAD in adult cognitive models of the disorder.ResultsThe interviews revealed both variety and commonalities in the experiences and interpretations of social events in children with SAD, captured in three related main themes: (i) Discomfort being the centre of attention, (ii) (Lack of) awareness of cognitions and (iii) Managing social fears. Findings indicated likely developmental influences on which maintenance mechanisms apply at which point in time.ConclusionsThere is variation in the psychological mechanisms that children with SAD endorse and developmental factors are likely to influence when specific mechanisms are relevant. We now need further studies that take a developmentally informed approach to understand the nature of the association between the factors identified in this study and social anxiety in childhood to inform the development of more effective interventions for childhood SAD.
Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia
Authors: Moreno David F. , López‐Guerra Mónica , Paz Sara , Oliver‐Caldés Aina , Mena Mari‐Pau , Correa Juan G. , Battram Anthony M. , Osuna Miguel , Rivas‐Delgado Alfredo , Rodríguez‐Lobato Luis Gerardo , Cardús Oriol , Tovar Natalia , Cibeira María Teresa , Jiménez‐Segura Raquel , Bladé Joan , Rosiñol Laura , Colomer Dolors , Fernández de Larrea Carlos 
Published: October 2022

SummaryWaldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in IgM monoclonal gammopathy of undetermined significance (MGUS) or smouldering WM (SWM) given the lower tumour load. Here, we used droplet digital polymerase chain reaction (ddPCR) to analyse MYD88 L265P and CXCR4 S338* mutations (C1013G and C1013A) in unsorted bone marrow (BM) or cell‐free DNA (cfDNA) samples from 101 IgM MGUS and 69 SWM patients. ddPCR was more sensitive to assess MYD88 L265P compared to allele‐specific PCR, especially in IgM MGUS (64% vs 39%). MYD88 mutation burden correlated with other laboratory biomarkers, particularly BM infiltration (r = 0.8; p < 0.001). CXCR4 C1013G was analysed in MYD88‐mutated samples with available genomic DNA and was detected in 19/54 (35%) and 18/42 (43%) IgM MGUS and SWM cases respectively, also showing correlation with BM involvement (r = 0.9; p < 0.001). ddPCR also detected 8 (38%) and 10 (63%) MYD88‐mutated cfDNA samples in IgM MGUS and SWM respectively. Moreover, high BM mutation burden (≥8% MYD88 and ≥2% CXCR4) was associated with an increased risk of progression to symptomatic WM. We show the clinical applicability of ddPCR to assess MYD88 and CXCR4 in IgM MGUS and SWM and provide a molecular‐based risk classification.
Multicenter retrospective study of initial treatment outcome and feasibility of initiating dose reduction of cabozantinib in unresectable hepatocellular carcinoma
Authors: Tomonari Tetsu , Tani Joji , Ogawa Chikara , Deguchi Akihiro , Senoh Tomonori , Moriya Akio , Shibata Hiroshi , Fukuno Hiroshi , Tanaka Hironori , Tanaka Takahiro , Taniguchi Tatsuya , Sogabe Masahiro , Kawano Yutaka , Morishita Akihiro , Takaguchi Koichi , Miyamoto Hiroshi , Sato Yasushi , Masaki Tsutomu , Takayama Tetsuji 
Published: October 2022

AbstractAimCabozantinib (CAB), a multiple kinase inhibitor, has been approved for use in patients with previously treated unresectable hepatocellular carcinoma (uHCC). However, real‐world clinical data are lacking, particularly clinical data regarding dose modifications of CAB. We analyzed the clinical outcomes of CAB in uHCC and compared treatment outcomes between the full‐ and reduced‐dose groups.MethodsThis multicenter, observational study included patients with uHCC who were treated with CAB from March 2021 to April 2022. Patient characteristics, efficacy, and safety were compared between the full‐ and reduced‐dose groups.ResultsTwenty‐six patients from eight institutes were analyzed. Cabozantinib was administered as a third‐line or later treatment in 25 (96.2%) patients and postimmunotherapy in 21 (80.5%) patients. There were 15 patients in the full‐dose group (60 mg CAB) and 11 in the reduced‐dose group (40 or 20 mg CAB). The objective response rate (ORR) and disease control rate (DCR) were not significantly different between the two groups. The ORR was 6.7% for the full‐dose group and 9.1% for the reduced‐dose group, and the DCR was 53.4% and 81.8%, respectively. Progression‐free survival analysis showed no significant differences between the two groups. The incidence of decreased appetite, fatigue, and diarrhea, and the rate of discontinuation and dose reduction, was significantly higher in the full‐dose group.ConclusionsOur study suggests that the efficacy and safety of CAB in real‐world clinical practice are comparable to those of the phase III trial (CELESTIAL), and that dose reduction of CAB may be a safer treatment option.
Nostalgia for Japanese colonialism: Historical memory and postcolonialism in contemporary Taiwan
Authors: Lin James 
Published: October 2022

AbstractTaiwan is unique among postcolonial societies today for a widespread social nostalgia for Japanese colonial rule. Contrasted with anti‐Japanese sentiment in neighboring East Asian societies like South Korea and China, Taiwan seems to present a puzzling instance of “pro‐colonial” nostalgia. This article discusses this phenomenon through reviewing recent scholarship of Japanese and Guomindang rule of Taiwan and Taiwanese postcolonialism. Nostalgia for Japanese colonialism in Taiwan emerged after the traumatic experiences of later Guomindang authoritarian rule and the politics of democratization and decolonization that followed the end of Guomindang martial law. While some of this social memory is shaped by a generation who lived through Japanese rule, much of the reshaping of Taiwan's historical memory is more complex than merely “pro‐colonialism.” Colonial nostalgia reflects a historical memory shaped by contemporary social experiences of trauma, counterhegemony, and postcolonial agency.