bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Predictors of Chronic PTSD Symptom Trajectories in US Army Soldiers Deployed to the Iraq War
Authors: Vasterling Jennifer J. , Franz Molly R. , Lee Lewina O. , Kaiser Anica Pless , Proctor Susan P. , Marx Brian P. , Schnurr Paula P. , Ko John , Concato John , Aslan Mihaela 
Published: November 2022

Abstract
Purpose
The course of posttraumatic stress disorder (PTSD) symptoms varies among veterans of warzones, but sources of variation in long-term course remain poorly understood. Modeling of symptom growth trajectories facilitates understanding predictors of individual outcomes over time. Although growth mixture modeling (GMM) has been applied to military populations, few studies have incorporated both pre-deployment and follow-up measurements over an extended time.
Methods
In this prospective study, 1087 US Army soldiers with varying military occupational specialties and geographic locations were assessed before and after deployment to the Iraq War, with long-term follow-up assessment occurring at least five years after return from deployment. The primary outcome variable was the PTSD Checklist, civilian version, summary score.
Results
GMM yielded four latent profiles: (1) primarily asymptomatic (n = 194; 17·8%), (2) post-deployment worsening symptoms (n = 84; 7·7%), (3) mild symptoms (n = 320; 29·4%), and (4) pre-existing, with chronic post-deployment elevation of symptoms (n = 489; 45·0%). Regression models comparing the primarily asymptomatic class to symptomatic classes revealed that chronic symptom classes were associated with greater stress exposure, less pre-deployment social support, identifying as a racial/ethnic minority, military reservist or veteran status at most recent assessment, and poorer pre-deployment visual memory.
Conclusions
PTSD symptom course varies considerably over time after military deployment and is associated with potentially modifiable biopsychosocial factors occurring early in its course, in addition to exposures and military status.
Trial Registration
: This study reported in this article was formally preregistered September 9, 2008 with ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT00748995).
Stapled Hemorrhoidopexy is non-inferior to excisional hemorrhoidectomy in long-term follow-up: A comparative study
Authors: Gefen Rachel , Handal Adham , Ben-Ezra Carmel , Parnasa Shani Y. , Mizrahi Ido , Abu-Gazala Mahmoud , Pikarsky Alon J. , Shussman Noam 
Published: November 2022

Abstract
Purpose: Symptomatic hemorrhoids are one of the most common perianal problems with various treatment options. Up to 20% of patients suffering from symptomatic hemorrhoids will require surgery. Excisional Hemorrhoidectomy (EH) and stapled hemorrhoidopexy (SH) are both standard and safe procedures. While SH has a short-term advantage of faster recovery and lower postoperative pain, its long-term efficacy is debatable. The purpose of this study was to compare the long-term outcomes of EH and SH.
Methods: This retrospective study compares outcomes of patients who underwent surgical treatment for symptomatic hemorrhoids in our institution during a time period of over 5 years. Eligible patients were contacted by phone and were asked to answer a questionnaire to evaluate recurrent symptoms, fecal incontinence, satisfaction, and quality of life improvement.
Results: Three hundred sixty-two patients were included, of whom 215 underwent SH, 99 underwent EH, and 48 underwent a combined procedure. Twenty-three patients (6.3%) suffered postoperative complications or were readmitted. There were no statistically significant differences between the groups regarding rate of complications, symptoms' recurrence, or fecal incontinence. A higher proportion of patients who underwent SH stated they would undergo the surgery again if they had to (p=0.011). There was no difference in quality of life improvement between the groups (p=0.904).
Conclusion: Stapled hemorrhoidopexy is non-inferior to hemorrhoidectomy in long-term follow-up regarding patient satisfaction, quality of life improvement, and symptoms' recurrence.
Determinants of Arabica Coffee Yield and Farmers’ Preference to Shade Trees Species at Jimma Zone, Southwestern Ethiopia
Authors: Garedew Weyessa , Alemayehu Yibekal , Bekeko Zelalem , Nebiyu Amsalu , Misgana Zerihun 
Published: November 2022

Abstract
Coffea arabica L. is one of the major economically important crops grown in the southwestern part of Ethiopia. However, the productivity of coffee is very low in the region. The main aim of the study was to assess the determinants of arabica coffee yield and farmers’ preference to shade tree species in Jimma zone, Southwestern Ethiopia. Two districts (Chora Botor and Limu Kossa) were selected purposively out of nine coffee-growing districts in Jimma zone. Three kebeles from Chora Botor and five kebeles from Limmu Kossa were randomly selected to run the household survey (399 randomly selected coffee growers). The collected data were analyzed using SPSS and STATA software. Ordinary Least square (OLS) regression models were implemented to resolve the determinant of coffee yield. The results indicated that socioeconomic and biophysical factors such as gender, education level, family size, coffee-growing experience, coffee farm size, weed management practices, disease, and insect pests were found to be determinants of coffee yield. Although the scale of shade tree preferences varies, farmers prefer coffee shade trees that have long heights, wider crown shapes, and evergreen leaves throughout the growing season. Accordingly, the ranking analysis in both districts indicated that Albizia gummifera, Acacia abyssinica, and Millettia ferruginea were the greatest preferred coffee shade tree species by farmers of the study area. Hence, improving the capacity of farmers about coffee farm management skills and promoting the use of preferred coffee shade trees should be strengthened to improve the coffee yield and quality in the region.
Determination of Performance Characteristics (eLOD50) for Verification of Qualitative Food Microbiological Measurement Methods Based on EN ISO 16140-3:2021
Authors: Khezri Mohammad , Khanzadi Saeid , Hashemi Mohammad 
Published: November 2022

Abstract
Verification of methods for the microbiological examination of foods is vital according to good laboratory practices (GLP) and ISO/IEC 17025. Microbiological reference methods increase the reliability of food quality control laboratory results. This study aimed to verify three qualitative reference methods by calculating the limit of detection at 50% (eLOD50) according to ISO 16140-3 and to address the related challenges for food microbiology laboratories. We determined the eLOD50 for detecting Escherichia coli, Staphylococcus aureus, and Salmonella spp. in different food items. For method implementation verification, the selected food items were fresh cheese Salmonella spp. and pasteurized milk for E. coli and S. aureus. For food item verification, the eLOD50 values of seven other food items (hamburger, black pepper, soybean powder, ultra-high temperature milk, minced meat, whole liquid pasteurized egg, and cake) were also assessed. The eLOD50 values were 0.5 and 1.9 CFU/test portion of pasteurized milk for E. coli and S. aureus, respectively, and 7.5 CFU/test portion in fresh cheese for Salmonella species. All calculated eLOD50 values were compared with acceptance limits. The calculated eLOD50 values of the qualitative methods complied with the acceptance criteria and were approved for all the selected food items.
The benign nature and rare occurrence of cardiac myxoma as a possible consequence of the limited cardiac proliferative/ regenerative potential: a systematic review
Authors: Shafi Ovais , Siddiqui Ghazia , Jaffry Hassam A 
Published: November 2022

Abstract
Background:
Cardiac Myxoma (CM) is a primary tumor of heart. Its origins, why the occurrence of primary cardiac tumors is extremely rare and how it may be related to limited cardiac regenerative potential, these aspects are not yet entirely known. This study investigates the key cardiac genes/TFs and signaling pathways to advance our understanding of these important questions.
Methods:
Databases including PubMed, MEDLINE, and Google Scholar were searched for published articles without any date restrictions, involving cardiac myxoma, cardiac genes/TFs/signaling pathways and their roles in cardiogenesis, proliferation, differentiation, key interactions and tumorigenesis, with focus on cardiomyocytes.
Results:
The cardiac genetic landscape is governed by a very tight control between proliferation and differentiation-related genes/TFs/pathways. Cardiac myxoma originates possibly as a consequence of dysregulations in the gene expression of differentiation regulators including Tbx5, GATA4, HAND1/2, MYOCD, HOPX, BMPs. Such dysregulations switch the expression of cardiomyocytes into progenitor-like state in cardiac myxoma development by dysregulating Isl1, Baf60 complex, Wnt, FGF, Notch, Mef2c and others.
The Nkx2-5 and MSX2 contribute to both proliferation and differentiation of Cardiac Progenitor Cells (CPCs) may possibly serve roles based on the microenvironment and the direction of cell circuitry in cardiac tumorigenesis. The Nkx2-5 in cardiac myxoma may serve to limit progression of tumorigenesis as it has massive control over the proliferation of CPCs. The cardiac cell type-specific genetic programming plays governing role in controlling the tumorigenesis and regenerative potential.
Conclusion:
The cardiomyocytes have very limited proliferative and regenerative potential. They survive for long periods of time and tightly maintain the gene expression of differentiation genes such as Tbx5, GATA4 that interact with tumor suppressors (TS) and exert TS like effect. The total effect such gene expression exerts is responsible for the rare occurrence and benign nature of primary cardiac tumors. This prevents the progression of tumorigenesis. But this also limits the regenerative and proliferative potential of cardiomyocytes. Cardiac Myxoma (CM) develops as a consequence of dysregulations in these key genes which revert the cells towards progenitor-like state, hallmark of CM. The CM development in carney complex also signifies the role of TS in cardiac cells.
Big Data Analytics by using Spark of Alrajhi Stock
Authors: DAORI HIND , ALZAHRANI GHAIDA , ALANAZI ALANOUD , ALHARTHI MANAR , Alhakamy A’aeshah 
Published: November 2022

Abstract
Big data sets require accurate prediction and anal- ysis, which is where big data analytics come in. They make it possible to find important information from enormous data sets that might otherwise be obscured. Three different data analytics methods—Spark, Hive, and MapReduce—are employed in this study to investigate a particular Arabian Company stock, Alrajhi. Using the data analytics technique MapReduce, the peak five-month value of the stock in 2022 is examined. Spark programming is used to track the five lowest prices at which the market was initially established in 2022, and the Hive approach is used to track the year with the biggest volume of purchases during the previous five years. Issues with Big that were significant
A viable method to replace the metal trocar drill guide in the inaccessibility of the long sagittal drill for mandibular fixation in BSSO
Authors: Samieirad Sahand , Torkzadeh Masoud , Grillo Ricardo 
Published: November 2022

Abstract
The bilateral sagittal split osteotomy requires many specific instruments. Many of them are not used by any surgical team other than the maxillofacial surgery team. The absence of some of these materials makes it practically impossible to perform or continue the operation, with a negative impact on the outcome. The present report aims to discuss an alternative in cases where long drills for drilling mandibular sagittal osteotomies are not available. An inexpensive method, available in all surgical centers.
An Intuitionistic Fuzzy and Contrast Limited Adaptive Histogram Equalization based Low-Light Color Image Enhancement Technique
Authors: Jebadass J Reegan , Balasubramaniam P 
Published: November 2022

Abstract
This paper proposes a new intuitionistic fuzzy-based algorithm for color image enhancement. A unique aspect of the proposed method is determining the degree of hesitation using Yager’s intuition-istic fuzzy generator technique. Here a boosting parameter α is used to stimulus the intuitionistic fuzzy image for enhancement technique. In this proposed method, first normal fuzzification transforms the given image into a fuzzy image. Then it is again transferred to an intuition-istic fuzzy image. Finally, one can get the proposed enhanced image after applying contrast limited adaptive histogram equalization. The proposed method is compared with other existing methods like brightness preserving dynamic fuzzy histogram equalization, histogram equalization , contrast limited adaptive histogram equalization, histogram specification approach, dehazing algorithm, intuitionistic fuzzy algorithm, and interval-valued intuitionistic fuzzy algorithm. We got better results through performance analyses like entropy, structural similarity index, absolute mean brightness error, and contrast improvement index. The outcomes uncovered that the proposed technique beats other existing strategies on generally speaking execution measurements and visual quality.
Mathematics Subject Classification (2020): 68U10 . 94D05
Implementation of filtered preamble GFDM system using USRP
Authors: Mangi Nageswararao Mangi , PRIYA P. Kavi 
Published: November 2022

Abstract
Data rate performance of the modern multicarrier techniques like generalized frequency division multiplexing (GFDM) has been significantlly limited by vital impairments like symbol time offset (STO) and carrier frequency offset (CFO). Traditional data aided methods of synchronization avoid the effect of egress noise in pilot preamble and hence destroying the spectral advantage of GFDM system. To safeguard this advantage, preamble needs to be pulse shaped. The main contribution of this paper is the derivation of generalized maximum likelihood (ML) estimation of frequency and time offsets for receiver synchronization in GFDM systems, using the modified preamble by the application of matrix inversion lemma. The dependency of the choice of the filter on Cramer-Rao lower bound (CRLB) of frequency offset estimation is also emphasized. The performance of the system is analysed over additive white Gaussian noise (AWGN) and multipath channel environments. The authors carried out real time implementation of GFDM system using IEEE 802.11 short preamble in indoor environments by employing national instruments (NI) universal software radio peripheral (USRP) 2953R boards as hardware platform which is interfaced with LABVIEW for practical validations of the results.
Androgens regulate CALCA gene expression in the prostate by methylation of CALCA Promoter
Authors: Masud Neshat , Chaudhary Jaideep , Shah Girish V. 
Published: November 2022

Abstract
Expression of calcitonin (CT) and its receptor (CTR) is frequently elevated in prostate cancer (PC), and activation of CT–CTR axis in non-invasive PC cells induces an invasive phenotype. However, the regulation of CT gene (CALCA) expression in the prostate has not been investigated. We investigated the regulation of CALCA gene expression in multiple PC cell lines and primary PC specimens. The results show that androgen-activated androgen receptor (AR) represses CALCA gene expression, and this can be abolished either by the knock-out of AR or the treatment with AR antagonists. Chromatin immunoprecipitation assay identified that AR induces methylation of CpG64 region of distal CALCA gene promoter, and this was prevented by knock-out of AR. This region was examined in multiple PC cell lines and primary PC specimens. PC cells that lacked CT mRNA abundance displayed methylated CpG64 region, and this methylation was partially reversed either with the knock-out of AR or incubation with AR antagonist. Primary prostate tissue specimens from normal or benign prostatic hyperplasia displayed methylated CALCA gene promoter. In contrast, those from advanced PCs displayed at least partially demethylated CALCA gene promoter. These results explain our earlier results that CALCA gene expression in the prostate is silent in benign prostate epithelium but is active in malignant prostate epithelium, and high level of CALCA gene expression in advanced PC. These results raise a possibility that elevated CALCA gene expression in malignant prostate may indicate progressive loss of AR expression and/or AR signaling.
Image encryption via a 2-D Logistic-Baker map and fractional discrete Meixner moments
Authors: Karawia A. A. , Fouda Y. M. 
Published: November 2022

Abstract
In this paper, we introduce an efficient and robust image encryption anddecryption scheme based on 2-D chaotic map and 2-D fractional discreteorthogonal moments. In the confusion stage, the compound LogisticBaker map is used to enhance the complexity and generate pseudorandom sequences. In order to resist a variety of attacks and increasesecurity, Fractional Discrete Meixner Moments (FrDMMs) are used in thediffusion stage. FrDMMs had been computed using the eigenvalues andthe corresponding multiplicity of the discrete Meixner polynomials. Thesecret key is created by combining the Logistic-Baker map and FrDMMs.The experimental results and the security analysis demonstrate that theproposed algorithm is robust against existing security attacks and hasa large key space, high key sensitivity, and a strong encryption effect.
The Development Trend of Sports Industry under the Vision of Internet of Things and Intelligent Edge Model
Authors: Hao Yangyang , Qiu Zhaoyi , Meng Linggang , Du Yuwei , Wu Minghua , Wang Chuyun 
Published: November 2022

Abstract
The Internet of Things(IoT) is one of the products of rapid development in the 5G era, and the cloud computing processing capabilities of edge computing are also very powerful. How to apply the IoT and edge computing to the forecast of sports industry trends is a problem. Therefore, this article studies the prediction of the development trend of sports industry from the perspective of the IoT and edge models. This paper proposes a multi-user QoE fairness bandwidth allocation modeling and model training service deployment algorithm to build a sports industry development prediction model based on the IoT and edge computing. And this paper designs an algorithm simulation experiment, and the experimental results show that its success rate is as high as 99%. So this article is based on the 2011-2017 Chinese sports industry trends to make predictions and comparisons, and the comparison results show that the similarity rate is as high as 90%.
Exosomes of mesenchymal stem cells reduce cholesterol-induced hepatic fibrogenesis by inhibiting TGF-β/Smad3 signaling pathway in LX2 cells
Authors: Rashidi Mojtaba , Afarin Reza 
Published: November 2022

Abstract
Dietary cholesterol is involved in the development of liver fibrosis, because free cholesterol accumulates in HSCs, can lead to Hepatic stellate cells (HSCs) sensitization to TGFβ. HSCs play a crucial role in the liver fibrosis process. This pathway can be targeted by anti-fibrotic therapies. MSCs-derived exosomes are known as the new mechanism of cell-to-cell communication which shows that exosomes have the potential to be used as a new treatment for diseases. In this study, we investigated the ability of exosomes of Whartons’ jelly of MSCs (WJ-MSCs) to reduce cholesterol-induced liver fibrosis in the LX2 cell line. MSCs were isolated from Wharton's jelly of the umbilical cord and the exosome was extracted from the supernatant of culture. LX2 cell line was cultured in DMEM medium with 10% FBS, then cells were treated with 75 and 100 µM concentrations of cholesterol for 24 h, respectively. The expression mRNA of genes of TGF-β, αSMA, collagen1α, and the level of Smad3 protein were measured to assess liver fibrosis. Exosome treatment significantly reduced the expression of TGF-β, α-SMA, collagen1α genes. Treatment with exosomes prevents the activation of HSCs by inhibiting the phosphorylation of Smad3 protein. Cholesterol increases the expression of TGF-β, α-SMA, collagen1α genes by increasing the phosphorylation of Smad3 protein.We observed that the exosomes of WJ-MSCs can inhibit the TGFβ/Smad3 signaling pathway that can prevent further activation of HSCs and progression of liver fibrosis. So, the exosome of WJ-MSCs s will be improving its therapeutic potential for liver failure.
Outcomes in patients with fractures of distal humerus using allografts for bone defect replacement
Authors: Davydov Aleksey P. , Petrov Aleksey B. , Ulyanov Vladimir Yu. 
Published: November 2022

Abstract
Traumatic injuries of the elbow joint that lead to severe consequences are quite common. The complex anatomy of distal humerus and frequent intra-articular localization of the injury turn treatment challenging, and the positive outcome is often impossible without bone plasty. The aim of this study is to present the outcomes in patients with distal humerus fractures (DHF) using various grafts to repair their bone defects. Both retrospective and prospective investigations of the outcomes in 20 DHF patients aged 40.5±9.5 years were carried out. The prevailing injury mechanism was falling on the elbow joint, in 8 cases out of 20 the injury resulted from a sport activity, in 2 cases – from car accidents. The standard 2 projections radiography was used to determine AO fracture type and bone fragments positioning while 3D computed tomography helped in case of multi-fragment fractures. Surgical reconstruction of the affected segment was performed 13±6 days later with various bone fixators by placing parallel, mutually perpendicular plates and screws according to the AO guidelines. Bone defect plasty involved spongy cadaveric bone powder allografts, synthetic granules or allografts of resected femoral heads produced by the Marburg Bone Bank System. Those with powder allografts and synthetic granules were included in Group A, and patients with femoral allografts produced by the Marburg Bone Bank System made up Group B. The operated elbow joints were assessed in 6-8 weeks by the international Broberg and Morrey rating system. In Group A (n=10), 1 patient had an excellent outcome of the surgery, 4 had good outcomes and 5 had satisfactory outcomes. In Group B (n=10), 2 patients had excellent outcomes, 5 had good outcomes, and 3 had satisfactory outcomes. Therefore, the correct choice of treatment tactics along with the early surgical intervention followed by a short immobilization time and early passive exercises in the operated elbow joint benefit the treatment outcome.
Patient Routing in the Delay Tolerant Networks
Authors: Ren Lili , OUYANG Jun , Liu Jing 
Published: November 2022

Abstract
Delay Tolerant Networks (DTNs) are unstable networks, where contemporaneous end to end paths don’t exist. This leads to the problem of how to route a packet from one node to another in such a network, involving whether to send a packet, when to send it and the energy consume control. The existing literature mainly focuses on the energy consumption of packet routing to a single destination node, seldom considering the influence of optimal choice about transmitting rate on network performance. The paper addresses this problem by modeling the packet delivery process of DTNs with multiple destinations adopting ordinary differential equations (ODEs). Furthermore, the tradeoff between delivery performance and energy consumption during packet delivery are mathematically characterized, proving that the maximization of tradeoff is a submodular function and an NP-hard problem. Then, an optimal control method called ‘patient routing’ is proposed to decide whether to send a packet and when the best time is through transmission probability and transmitting rate judgments. Before that time, the node will wait patiently. Our simulations reveal that the proposed routing can significantly reduce nodes energy consumption and achieve higher tradeoff over the other three routings.