bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of process parameters on vitamins and sensory acceptability in micronutrient‐fortified soymilk prepared by small‐scale batch processing
Authors: Hardy Dallin M. , Pike Oscar A. , Taylor Bradley J. , Dunn Michael L. 
Published: December 2022

AbstractEffects of holding time before cooling, cooling method, and light or dark refrigerated storage on the stability of vitamin A, vitamin C, thiamine, riboflavin, and folate were investigated in fortified and unfortified soymilk. Vitamin C loss (6%) and mild vitamin A isomerization occurred when soymilk was held hot after fortification. Cooling bottled soymilk at ambient temperature or in an ice‐water bath did not affect any vitamins. Loss of riboflavin (18%) and vitamin A isomerization occurred during 12 days of light‐exposed refrigerated storage, in contrast to no vitamin degradation during dark refrigerated storage. A sensory panel of youth and children indicated no significant preferences between fortified and unfortified soymilk except for color, where the lighter‐colored unfortified soymilk was preferred. Acceptable vitamin stability and sensory characteristics can be achieved in fortified soymilk produced in small‐scale batch processes with appropriate management of production and storage conditions.
COVID‐19 and tail risk contagion across commodity futures markets
Authors: Qiao Tongshuai , Han Liyan 
Published: December 2022

AbstractThis paper examines the impact of COVID‐19 on tail risk contagion across commodity futures markets using a copula‐based network method. We document a significant increase in the lower and upper tail contagiousness of commodities following the COVID‐19 outbreak. Contagion shows an obvious clustering characteristic, that is, there is higher tail risk connectedness between commodities in the same category. Agricultural commodities are significantly less contagious than metals and energy commodities; soft commodities in particular can offer investors significant diversification benefits. There are several hub commodities in the contagion network, chief among them copper, which are good transmitters of shocks and should be treated with caution by investors and regulators. Although tail risk and contagiousness of individual commodities increase together during the pandemic, we find a negative cross‐sectional relationship between tail risk and contagiousness, that is, commodities with high tail risk are not necessarily highly contagious and may even be less so.
TFG::MET‐rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low‐grade triphasic morphology
Authors: Michal Michael , Ud Din Nasir , Švajdler Marián , Klubíčková Natálie , Ptáková Nikola , Hájková Veronika , Michal Michal , Agaimy Abbas 
Published: December 2022

AbstractThis article presents 2 cases of TFG::MET‐rearranged mesenchymal tumor, an extremely rare molecular subset among an emerging group of mesenchymal neoplasms with kinase gene (NTRK, BRAF, RET and others) alterations. Both tumors were congenital, occurred in female patients and presented as huge masses on the trunk and thigh, measuring 18 and 20 cm in the largest dimension. Both cases showed identical areas with a distinctive triphasic morphology resembling fibrous hamartoma of infancy (FHI), consisting of haphazardly arranged ovoid to spindled cells traversed by variably cellular and hyalinized fascicles admixed with (most likely non‐neoplastic) adipose tissue. In other areas, a high‐grade infantile fibrosarcoma/malignant peripheral nerve sheath tumor‐like (IFS/MPNST‐like) morphology was present in both cases. While the first case co‐expressed CD34 and S100 protein, the other case did not. When combined with the three previously reported MET‐rearranged cases (of which two harbored TFG::MET fusion), 3/5 and 3/4 of MET‐rearranged and TFG::MET fusion‐associated tumors, respectively exhibited similar triphasic FHI‐like low‐grade morphology. This points toward the existence of a relatively distinct morphological subset among kinase‐fusion‐associated tumors which seems to be strongly associated with MET fusions. It seems some of these low‐grade cases may transform into a high‐grade variant with IFS/MPNST‐like morphology as has been observed in other tumors with kinase gene fusions. While most cases seem to follow an indolent clinical course, the recognition of these tumors is clinically relevant as MET tyrosine kinase inhibitors might represent an effective treatment option for clinically aggressive or unresectable cases.
Petrogenesis of the Eocene Yulong potassic intrusion in non‐subduction setting in the Sanjiang Tethys
Authors: Du Bin , Yang Zi'an , Wang Changming , Chen Qi , Yang Lifei , Shi Kangxing , Zhu Jiaxuan , Li Gao , Wang Lei , Lu Jia 
Published: December 2022

The giant Yulong porphyry Cu (‐Mo‐Au) deposit was formed in a post‐collisional setting in eastern Tibet, which is associated with Eocene potassic to ultrapotassic felsic intrusive rocks. The origin of the Yulong potassic intrusion remains highly disputed. Hence, we present new zircon U–Pb ages, whole‐rock geochemistry and zircon Lu‐Hf isotopes for the Yulong intrusion. Zircon U–Pb dating from the porphyritic monzogranite and porphyritic quartz monzonite yield ages of 41.1 ± 0.2, 40.8 ± 0.1 and 40.5 ± 0.2 Ma, respectively. Samples from the Yulong intrusion exhibit high K2O (4.13–4.85%), and high K2O/Na2O (1.00–1.25), [La/Yb]n (30.37–40.37) and Sr/Y (57.86–87.68) ratios, low Mg#, MgO, Ni, and Cr contents, enrichment in light rare earth elements (LREEs) and depletion of high‐field‐strength elements (HFSEs, e.g., Nb, Ta, and Ti). Zircon grains from this study have mostly positive εHf(t) values (+1.6 to +2.9), and crustal model ages (TDMC) of 0.90–1.19 Ga. These features suggest that the Yulong intrusion is derived from a thickened juvenile lower crust. During the Permian to late Triassic, Jinshajiang‐Ailaoshan Palaeo‐Tethyan oceanic subduction from the eastern margin of the North Qiangtang produced metasomatic domains within the continental lithospheric mantle and lower crust. During the late Eocene, the continuing India‐Asia continental collision may have preferentially overthickened the crust. Convective removals in the lower part of the thickened lithosphere resulted in the hot asthenosphere upwelling along the Jinshajiang‐Ailaoshan Suture, which induced the partial melting of the residual metasomatized lithospheric mantle, as well as the thickened lower crust in the Eocene, which formed the Yulong intrusion.
An observational, prospective, multicenter study on the utilization and effectiveness of elbasvir–grazoprevir treatment association for chronic hepatitis C in France (ZEPHYR study)
Authors: Bronowicki Jean‐Pierre , Miailhes Patrick , Hanslik Bertrand , Ouzan Denis , Larrey Dominique , Riachi Ghassan , Truchi Régine , Jouannaud Vincent , Pospait Dan , Abergel Armand , Causse Xavier , Perot Stéphanie , Skrzypski Jérémy , De Hautecloque Astrid , Spampinato Axelle , Mariot Philippe , Sogni Philippe ,   the Zephyr Study group
Published: December 2022

AbstractBackground and AimThe efficacy and safety profiles of elbasvir–grazoprevir (EBR/GZR) has been established in more than 10 clinical trials. However, the characteristics of patients treated in routine clinical practice may differ. The present study was therefore designed to assess the real‐life effectiveness of EBR/GZR therapy in the general population and among subgroups with a high hepatitis C virus (HCV) prevalence in France.MethodsThe Zephyr study was designed as a French, multicentre, prospective, observational study on EBR/GZR use and effectiveness in current practice in chronic hepatitis C patients. These results are based on data regarding the adult patients who received at least one dose of EBR/GZR between December 2017 and June 2019 in 67 French hospitals and clinics.ResultsOverall, 478 patients were included. The Full Analysis Set corresponded to the 467 patients who met all the inclusion criteria and none of the exclusion criteria. Gender was balanced and the mean age was 55.7 ± 13.3 years. The patients were mainly treatment‐naive (89.5%) and infected with Genotype 1b (70.4%). Among the 75 patients with HCV Gt1a genotype, 56% had HCV RNA ≥ 800,000 IU/ml. F3–F4 fibrosis stage involved 24.2% of our population. Our subgroups were distributed among 110 migrants (23.6%), 58 (15.3%) using opioid agonist treatment, including people who inject drugs, 30 (6.8%) with chronic kidney disease Stages 3–5, 9 (1.9%) with an inherited blood disorder, and 4 (0.9%) coinfected with HIV. The remaining 269 (58.7%) were included in the general population subgroup. Overall, sustained virologic response 12 weeks after the end of treatment reached 98.0% and remained consistent among genotype, HCV RNA values, fibrosis stage, and the subgroup of interest. The rate of Alcohol Use Disorders Identification Test‐Consumption​​​ and Life Habit questionnaire completion was high at each visit, with data suggesting alcohol consumption decrease and an improvement in quality of life.ConclusionsUsing real‐world evidence data on a French population representative of HCV patients, we confirmed the results obtained during EBR/GZR development program.
COVID‐19 and the increase in schizophrenia incidence in the future: A hypothesis and a serious warning
Authors: Pourfridoni Mohammad , Askarpour Hedyeh 
Published: December 2022

AbstractBackground and AimsThe coronavirus disease 2019 (COVID‐19), which has caused a global pandemic, is brought on by the Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2). Since the COVID‐19 pandemic started so recently, dealing with complications that emerge years later and have the potential to cause several crises for humanity is one of the issues we face in the post‐COVID‐19 age. Therefore, we wish to discuss a theory and potential dangers surrounding the probability of schizophrenia following COVID‐19 infection in this study.MethodsThe literature search for this article has been entirely internet‐based. Information was gathered using the Web of Science, PubMed, Scopus, and Google Scholar databases.ResultsThe results showed that multiple immune system changes brought on by COVID‐19 have been identified as potential causes of schizophrenia.ConclusionIt is predicted that one of the long‐term effects of COVID‐19 is an increase in the risk of schizophrenia incidence based on the results of this study, which looked at the pathophysiology and etiology of schizophrenia as well as the pathogenic mechanisms of the SARS‐CoV‐2. Therefore, healthcare staff should be prepared to handle any potential risks in future.
Trends and future projections of cervical cancer‐related outcomes in Japan: What happens if the HPV vaccine program is not implemented?
Authors: Sakakibara Atsuko , Nakayama Takeo , Uchida Hiroyuki , Odagiri Youichi , Ito Yuri , Katayama Toshiro , Ueda Yutaka , Higuchi Toshihiro , Terakawa Koichi , Matsui Kunihiko , Miyazaki Kikuko , Konishi Ikuo 
Published: December 2022

AbstractContrary to other developed countries, in Japan, recent years have seen increases in cervical cancer incidence and mortality among young people. However, the human papillomavirus (HPV) vaccine program, a key measure for avoiding cervical cancer, has been virtually suspended. Temporal changes in cervical cancer profiles in this unique situation have not been fully investigated epidemiologically. Our study aimed to determine the current status and future trends of the incidence and mortality of cervical cancer and precancerous lesions in Japan. Mortality rates of cervical cancer during 1975 to 2016 and incidence rates of cervical cancer and cervical intraepithelial neoplasia (CIN) 3 during 1975 to 2013 were examined using vital statistics and population‐based cancer registry data in Japan. Bayesian age‐period‐cohort analyses were performed to analyze temporal changes of the three cervical cancer‐related outcomes. We also calculated projections to 2028 for the three outcomes, assuming that HPV vaccination coverage and screening rates in Japan would be maintained at the current level after the resumption of the national vaccination program. The risk of occurrence of the three outcomes showed similar changes by birth cohort, peaking in the mid‐1890s to 1900s birth cohorts, declining sharply in the 1940s birth cohort, and persistently increasing in the 1950s and later birth cohorts. Projections to 2028 show increases in cervical cancer incidence and mortality in the 30 to 69 age group, with a particular increase in CIN3 incidence in the 25 to 49 age group, if HPV vaccine programs and screening are not effectively implemented. These findings revealed an increasing cervical disease burden among reproductive age females in Japan.
Multi‐level deep learning based lung cancer classifier for classification based on tumour‐node‐metastasis approach
Authors: Pawar Swati P. , Talbar Sanjay N. 
Published: December 2022

AbstractTreatment of non‐small cell lung cancer depends on detecting the cancer stage. The oncologist decides the cancer stage based on the tumour‐node‐metastasis (TNM) staging suggested by the American Joint Committee on Cancer (AJCC). This study simplifies the complicated problem of classifying computed tomography (CT) images into TNM‐based classes using deep learning algorithms at various levels. In the first level, an optimised conditional generative adversarial network (c‐GAN) network is developed for automatic lung segmentation, including nodules within the lung and juxtapleural nodules. Earlier studies used time‐consuming manual identification of the region of interest patches from the lung CT image before applying the deep learning classification algorithm. At the next level, three different deep learning algorithms, along with three support vector machine classifiers, are used for the classification of Tumour, Node and Metastasis as per the AJCC staging nomenclature. The specially designed c‐GAN network's performance is maximised using the Taguchi approach, which helps automatically preprocess CT images by removing unwanted background noises. Further, three different pre‐trained Resnet50 networks are trained using transfer learning for extracting the deep features for finally applying to three different classifiers, resulting in three different classes. The comparative segmentation performance assessment in the form of the average dice similarity coefficient and Jaccard index indicates that the proposed c‐GAN gives the best segmentation performance of the lung without losing the nodule compared to other segmentation algorithms. The proposed approach gives the classification performance for the Tumour as 91.94%–97.32%, the Nodule as 91.99%–100%, and the Metastasis as 99.25%–100.00%.
Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators
Authors: Wu Changwu , Tan Jun , Wang Xiangyu , Qin Chaoying , Long Wenyong , Pan Yimin , Li Yuzhe , Liu Qing 
Published: December 2022

AbstractImbalance in copper homeostasis can be lethal. A recent study found that excess copper induces cell death in a way that has never been characterized before, which is dependent on mitochondrial stress and is referred to as “cuproptosis.” The role of cuproptosis in tumors has not yet been elucidated. In this study, we revealed the complex and important roles of cuproptosis regulators and cuproptosis activity in tumors via a comprehensive analysis of multiomics data from more than 10,000 samples of 33 tumor types. We found that the cyclin‐dependent kinase inhibitor 2A is the most frequently altered cuproptosis regulator, and the cuproptosis regulator expression is dysregulated in various tumors. Additionally, we developed a cuproptosis activity score to reflect the overall cuproptosis level. On the basis of the expression levels of cuproptosis regulators, tumors can be divided into two clusters with different cuproptosis activities and survival outcomes. Importantly, cuproptosis activity was found to be associated with the prognosis of multiple tumors and multiple tumor‐related pathways, including fatty acid metabolism and remodeling of the tumor microenvironment. Furthermore, cuproptosis increased the sensitivity to multiple drugs and exhibited potential to predict the outcome of immunotherapy. We also comprehensively identified cuproptosis‐related microRNAs, long noncoding RNAs, and transcription factors. We provided the code corresponding to the results of this study in GitHub (https://github.com/Changwuuu/Cuproptosis-pancancer.git) for reference. In summary, this study reveals important molecular and clinical characteristics of cuproptosis regulators and cuproptosis activity in tumors, and suggests the use of cuproptosis as a promising tumor therapeutic approach. This study provides an important reference point for future cuproptosis‐related research.
Heterogeneous impacts of the spot check‐list program in US crop insurance: A disaggregated analysis at the crop level
Authors: Park Sungkwol , Zheng Xiaoyong 
Published: December 2022

AbstractThis article examines the heterogeneous impacts of the “Spot Check List” (SCL) on producer claims filing behavior across five major crops. Our proposed empirical approach takes into account all the salient data features, namely, state dependence, nonnegativeness of the dependent variable, two‐way fixed effects, observed heterogeneity, as well as potentially endogenous control variables. Our results show that the SCL program is effective in reducing the amount of claims filed by producers of corn, soybeans, and cotton, but there is no evidence that it has a statistically significant impact on producers of wheat and tobacco.
Reducing food insecurity through equitable investments in irrigation: The case of Niger
Authors: Kafle Kashi , Balasubramanya Soumya 
Published: December 2022

AbstractWe use Niger as a case study to examine the relationship between irrigation and household food security controlling for the point of crop harvest sales. We use longitudinal household and agriculture data collected by the Living Standards Measurement Study. Using panel fixed effects, we find that irrigation was associated with a 10% decrease in food insecurity, a 9% increase in food consumption expenditure, and improved dietary diversity. Farmers using irrigation experienced higher cash incomes, sold a higher share of the harvest, and had higher crop revenues. Access to irrigation was also positively correlated with the consumption of nutritious food items such as fruits, vegetables, and meat products. Importantly, these effects were found for both farmers using irrigation that primarily sold their harvest locally to neighbors and village shops, as well as for farmers using irrigation who sold in bulk to regional or national traders. Results suggest that investing in irrigation can improve food security, even in areas with limited access to formal markets.
The use of cardiac ultrasound imaging in first‐trimester prenatal diagnosis of congenital heart diseases
Authors: Ximenes Renato Silveira , Bravo‐Valenzuela Nathalie Jeanne , Pares David Baptista Silva , Araujo Júnior Edward 
Published: December 2022

AbstractThis study aims to explore ultrasound (US) cardiac and echocardiographic features that may enable the early diagnosis of various major congenital heart diseases (CHDs). Focusing on providing useful US tools for this assessment, high resolution of US cardiac images of various CHDs, such as hypoplastic left heart syndrome, conotruncal anomalies, and univentricular heart, were evaluated. Results show that early US detection of most major CHDs is feasible during first‐trimester ultrasonography cardiac evaluation. Concerns about safety issues, findings on early fetal cardiovascular hemodynamics, and cardiac lesions that can progress during the course of pregnancy were also discussed.
Genome wide analysis of dexamethasone stimulated mineralization in human dental pulp cells by RNA sequencing
Authors: Tang Jia , Wang Zuolin 
Published: December 2022

AbstractHuman dental pulp cells (hDPCs) contain mesenchymal stem cells and are therefore indispensible for reparative dentin formation. Here, we present a pilot study of transcriptomic profiles of mineralized hDPCs isolated from sound human maxillary third molars. We observed altered gene expression of hDPCs between control (dexamethasone free) and experimental (dexamethasone 1 nm) groups. Differential expression analysis revealed up‐regulation of several inflammation and mineralization‐related genes in the experimental group. After a Gene Ontology analysis for predicting genes involved in biological process, cellular component and molecular function, we found enrichment of genes related to protein binding. Based on the results of Kyoto Encylopedia of Genes and Genomes pathway analysis, it is suggested up‐regulated genes in mineralized hDPCs were mostly enriched in the mitogen‐activated protein kinase (MAPK) signaling pathway, fluid shear stress and the atherosclerosis signaling pathway, etc. Importantly, Gene Set Enrichment Analysis revealed dexamethasone was positively related to the Janus kinase/signal transducer and activator of transcription, MAPK and Notch signaling pathway. Moreover, it was suggested that dexamethasone regulates signaling pathway in pluripotency of stem cells. Collectively, our work highlights transcriptome level gene regulation and intercellular interactions in mineralized hDPCs. The database produced in the present study paves the way for further investigations looking to explore genes that are involved in dental pulp cells mineralization.
Influence of Scandinavian teleconnection pattern on summer precipitation over the eastern side of the Tibetan Plateau
Authors: Chen Quanliang , Zhang Ziqi , Li Yang , Liao Yujing , Chen Huanhuan 
Published: December 2022

AbstractThis study analyses the relationship between the Scandinavian (SCA) teleconnection pattern and summer precipitation over the eastern side of the Tibetan Plateau (ESTP) between 1960 and 2020 and further studies the underlying physical mechanism. Statistical analysis showed that there is a significant and high negative correlation coefficient (around −0.59) between ESTP summer precipitation and the SCA teleconnection pattern over the period 1960–2020. When the SCA teleconnection pattern is in its negative phase, there is a significant increase in precipitation over most of the ESTP, and vice versa. Moisture budget analysis showed that vertical moisture advection makes a larger contribution to precipitation changes related to the SCA teleconnection pattern than evaporation and horizontal moisture advection. Specifically, positive precipitation anomalies related to the SCA teleconnection pattern are dominated by the enhanced dynamic component of vertical moisture advection, which is induced mainly by the significant ascending motion over almost the whole of the ESTP region. In summer, under the effect of the SCA teleconnection pattern, the abnormal westerly wind transports the mean warm air from TP to ESTP and forms an abnormal warm advection over the ESTP, resulting in a significant vertical upward motion and more summer precipitation over the ESTP. This study reveals the possible physical mechanism of the impacts of SCA teleconnection pattern on summer precipitation over the ESTP region and provides a scientific basis for ecological protection and disaster mitigation measures associated with major projects such as the Sichuan–Tibet railway and the Chengdu–Chongqing Economic Circle.