bluuebunny/crossref_metadata_2025_split huggingface dataset:
Objective Personality Determination: A Useful Addition to the Traditional Process of Pediatric Surgical Fellow Selection
Authors: Sacks Marla A. , Khan Faraz A. , Hazboun Rajaie , Radulescu Andrei , Tagge Edward P. 
Published: May 2022

BackgroundSelection of pediatric surgical trainees is a multifaceted process heavily influenced by in-person interviews to determine personality makeup and institutional compatibility. We present our experience in utilizing a validated personality inventory in the selection of our candidates.MethodsAll applicants selected for an in-person interview for the 2020 Pediatric Surgery Match were offered the Big Five Inventory (BFI) questionnaire. An initial rank order list (ROL) was formulated employing application information and in-person interview score. A reformulated ROL was created after incorporating BFI data. Correlation of specific personality characteristics vs position on the ROL was assessed for both the initial ROL and the reformulated ROL.ResultsThirty-four applicants were interviewed and 24 (70.6%) were ranked. Linear regression analysis identified a lower neuroticism score directly related to a higher position on the initial ROL {R = .4626, P = .023}. The reformulated ROL identified a higher conscientiousness score {R = .5331; P = .007} and a lower neuroticism score {R = −.4383; P = .032} correlated with ascending the final ROL.ConclusionsThe self-administered BFI adds objectivity to personality determination gleamed from the standard face-to-face interview. Conscientiousness and neuroticism had a significant impact on the final ROL position. Adding objective personality data appears to provide additional aid in this difficult process.
Long-term open-label safety study of galcanezumab in patients with episodic or chronic cluster headache
Authors: Riesenberg Robert , Gaul Charly , Stroud Chad E , Dong Yan , Bangs Mark E , Wenzel Richard , Martinez James M , Oakes Tina Myers 
Published: May 2022

Background CGAR, a Phase 3b open-label study, evaluated the long-term safety of galcanezumab in patients with cluster headache who completed one of two Phase 3 double-blind studies in chronic or episodic cluster headache. Methods Patients (N = 164) received galcanezumab 300 mg subcutaneously up to once a month. Primary endpoint was safety, as assessed by treatment-emergent adverse events, serious adverse events, and suicidality. Other endpoints included discontinuation rates, immunogenicity, efficacy as assessed by the Patient Global Impression of Improvement, and health values. Results At baseline, mean (standard deviation) age was 48.3 (9.8) years, 75.0% were men, and 85.4% were white. Treatment-emergent adverse events (n = 119 [72.6%]) were mostly mild-to-moderate, with nasopharyngitis the most commonly reported (22.0%). One of 18 serious adverse events was judged as treatment related (constipation). Two patients (1.2%) reported suicidal ideation. Five patients (3.1%) discontinued due to an adverse event. Eight patients were treatment-emergent anti-drug antibody positive, two of whom were not treatment-emergent anti-drug antibody positive in the parent studies. On the Patient Global Impression of Improvement, ≥81% reported their cluster headache status as very much, much, or a little better at Months 1, 6, and 12. Health value scores generally improved from baseline. Conclusions In this open-label study, galcanezumab was generally well tolerated and improved patient-reported cluster headache status. Trial registration number: NCT02797951; https://clinicaltrials.gov/ct2/show/NCT02797951
Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients
Authors: Fathalla Lamiaa A , Kamal Lamyaa M , Salaheldin Omina , Khalil Mahmoud A , Kamel Mahmoud M , Fahim Hagar H , Abdel-Moneim Youssef AS , Abdulhakim Jawaher A , Abdel-Moneim Ahmed S , El-Meligui Yomna M 
Published: May 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic resulted in more than five hundred million infected cases worldwide. The current study aimed to screen the correlation of different laboratory findings with disease severity and clinical outcomes of coronavirus disease (COVID-19) among Egyptian patients to obtain prognostic indicators of disease severity and outcome. A total of 112 laboratory-confirmed COVID-19 patients were examined. According to the severity of the disease, these patients were divided into three main groups: mild, moderate and severe cases. In addition, clinical characteristics and laboratory findings, including Hb, platelet count, white blood cell count, lymphocyte percentage, neutrophil percentage, neutrophil lymphocyte ratio (NLR), D-dimer, highly sensitive C-reactive protein (HS-CRP), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and creatinine, were measured. The presence of hypertension and/or diabetes was found to be a significant risk factor for disease severity and poor outcome. Increased respiratory rate, levels of SpO2, HS-CRP, D-dimer, NLR, ALT, LDH, lymphopenia and neutrophilia, as well as changes in chest computed tomography (CT), were associated with increased disease severity and fatal consequences. Highly sensitive C-reactive protein, D-dimer, NLR and LDH constituted excellent predictors for both disease severity and death. Laboratory biomarkers, such as HS-CRP, D-dimer, NLR and LDH, are excellent predictors for both disease severity and death. They can predict mortality in patients at the time of admission secondary to SARS-CoV-2 infection and can help physicians identify high-risk patients before clinical deterioration.
Physical Activity and Multimorbidity Among Community-Dwelling Older Adults: A Systematic Review With Meta-Analysis
Authors: Delpino Felipe Mendes , de Lima Ana Paula Maciel , da Silva Bruna Gonçalves Cordeiro , Nunes Bruno Pereira , Caputo Eduardo Lucia , Bielemann Renata Moraes 
Published: May 2022

ObjectiveThis study evaluated the relationship between physical activity (PA) and multimorbidity in community-dwelling older adults.Data SourceA systematic review and meta-analysis in the following databases: Pubmed, Lilacs, Scielo, Web of Science, Scopus, and AgeLine.Study inclusion and Exclusion CriteriaIt included observational studies investigating the association between physical activity and multimorbidity, with older adults, published until May 2021. Studies with institutionalized individuals or that assessed specific diseases were excluded.Data ExtractionTwo reviewers independently extracted the studies based on previous inclusion and exclusion criteria, started by selecting titles, followed by abstracts and full-text reading.Data SynthesisMeta-analysis results were reported as Odds Ratio (OR) with a 95% confidence interval using R language. The Newcastle Ottawa scale was used to assess the quality of the studies.ResultsFifteen studies were included in the systematic review, from which 12 reported an inverse association between physical activity and multimorbidity. In the meta-analysis, from over 77 000 older adults, there was an inverse association between physical activity and multimorbidity [OR: .81; 95% CI: .73-.89]. We found significant results only for men in the analysis by sex.ConclusionsLow levels of physical activity were associated with a higher risk of multimorbidity in older adults. It is expected that public policies will be conducted aimed at the practice of physical activity among older adults.
The Use of Music to Manage Burnout in Nurses: A Systematic Review
Authors: Finnerty Rachael , Zhang Katherine , Tabuchi Rina A. , Zhang Kevin 
Published: May 2022

Objective There is a high prevalence of burnout in nurses. This systematic review investigates the use of music to manage burnout in nurses. Data Source MEDLINE (Ovid), MEDLINE InProcess/ePubs, Embase, APA PsycINFO, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases were searched. Study Inclusion and Exclusion Criteria Full-text articles were selected if the study assessed the use of music to manage burnout in nurses. Burnout was defined according to the International Classification of Diseases 11th Revision. Data Extraction Data were extracted using an Excel sheet. The second and third authors independently extracted study characteristics, frequency and type of music engagement, measures of burnout, and burnout outcomes (occupational stress, coping with stress, and related symptoms such as anxiety). Data Synthesis Study and outcome data were summarized. Results The literature search resulted in 2210 articles and 16 articles were included (n = 1205 nurses). All seven cross-sectional studies reported upon nurses’ self-facilitated use of music including music listening, playing instruments, and music entertainment for coping or preventing stress, supporting wellbeing, or enhancing work engagement. Externally-facilitated music engagement, including music listening, chanting, percussive improvisation, and song writing, was reported in the four randomized controlled trials and five cohort studies with reductions in burnout outcomes. Conclusions Self-facilitated and externally-facilitated music engagement can help to reduce burnout in nurses.
Duty of care trumps utilitarianism in multi-professional obesity management decisions
Authors: McAloon Toni , Coates Vivien , Fitzsimons Donna 
Published: May 2022

Background Escalating levels of obesity place enormous and growing demands on Health care provision in the (U.K.) United Kingdom. Resources are limited with increasing and competing demands upon them. Ethical considerations underpin clinical decision making generally, but there is limited evidence regarding the relationship between these variables particularly in terms of treating individuals with obesity. Research aim To investigate the views of National Health Service (NHS) clinicians on navigating the ethical challenges and decision making associated with obesity management in adults with chronic illness. Research design A cross-sectional, multi-site survey distributed electronically. Participants A consensus sample of nurses, doctors, dietitians and final year students in two NHS Trusts and two Universities. Ethical considerations Ethical and governance approvals obtained from a National Ethics Committee (11NIR035), two universities and two teaching hospitals. Results Of the total ( n = 395) participants, the majority were nurses (48%), female (79%) and qualified clinicians (59%). Participants strongly considered the individual to have primary responsibility for a healthy weight and an obligation to attempt to maintain that healthy weight if they wish to access NHS care. Yet two thirds would not withhold treatment for patients with obesity. Discussion While clinicians were clear about patient responsibility and obligations, the majority prioritised their duty of care and would not invoke a utilitarian approach to decision making. This may reflect awareness of obesity as a multi-faceted entity, with responsibility for support and management shared amongst society in general. Conclusions The attitudes of this sample of clinicians complemented the concept of the health service as being built on a principle of community, with each treated according to their need. However limited resources challenge the concept of needs-based decisions consequently societal engagement is necessary to agree a pragmatic way forward.
Insomnia Symptoms Among Hospice Family Caregivers: Prevalence and Association with Caregiver Mental and Physical Health, Quality of Life, and Caregiver Burden
Authors: Starr Lauren T. , Washington Karla , McPhillips Miranda V. , Pitzer Kyle , Demiris George , Oliver Debra Parker 
Published: May 2022

Background Poor sleep exacerbates mental health problems and reduces quality-of-life (QOL) but prevalence of insomnia symptoms among hospice family caregivers and associations of poor sleep with caregiver health and QOL outcomes are not known. Objective To describe prevalence of insomnia symptoms among hospice family caregivers and compare anxiety, depression, self-rated health, QOL, and caregiver burden between hospice family caregivers with and without insomnia symptoms. Methods Descriptive sub-study using data collected during baseline interviews of hospice family caregivers involved in a randomized clinical trial in Midwestern United States (xxxxxxxx). Caregivers were dichotomized based on Insomnia Severity Index (ISI) scores (8+ indicated insomnia symptoms). Results Among 57 hospice family caregivers, the mean ISI score was 8.2; nearly half (49.1%) experienced insomnia symptoms. Compared to caregivers without insomnia symptoms, caregivers with insomnia symptoms reported 2.4 times greater mean anxiety scores (4.7 vs 11.4); 3.5 times greater mean depression scores (3.1 vs 10.7); 2.1 times greater caregiver burden scores (5.6 vs 11.8); and 1.3 times lower self-rated health (3.5 vs 2.8); 1.3 times lower total QOL scores (29.3 vs 22.6); including differences in emotional QOL (7.9 vs 2.2), social QOL (7.2 vs 3.0), and physical QOL (7.4 vs 5.3). Conclusions Hospice family caregivers experience high prevalence of insomnia symptoms; caregivers with insomnia symptoms report worse anxiety, depression, caregiver burden, QOL, self-rated health. Clinicians must screen hospice caregivers for poor sleep and mental health and offer supportive interventions that improve their sleep and health. Policy makers must expand hospice benefits to better support family caregivers.
Hepatitis C Virus Prevalence, Medical Status Awareness and Treatment Engagement among Homeless People Who use Drugs: Results of a Street Outreach Study
Authors: Lasmanovich Rinat , Shaked Or , Sivan Ayelet , Barak Idan , Nahari Mor , Mor Orna , Katchman Helena 
Published: May 2022

Background: Hepatitis C virus (HCV) infection is a primary health concern among people who use drugs (PWUDs). Homeless PWUDs that constitute a key population for HCV transmission remain underrepresented in many surveys. Objectives: We performed a proactive street outreach to evaluate HCV infection prevalence among homeless PWUDs in Tel Aviv, identify risk factors associated with HCV infection, awareness of disease status and linkage to care rate. Results: Thirty-eight percent of approached PWUD were willing to participate in the study. Out of 53 subjects who got tested for anti HCV by rapid test, 29 (54.72%) had a positive result, 20 of 29 anti-HCV positive (69%) patients had positive HCV PCR. Risk factors were investigated using structured questionnaires. Heroin use was reported significantly more frequently in the HCV-positive group ( P =  .05, CI 95%), whereas other established risk factors did not reach significance in our cohort. While 21 of 29 (72%) HCV-positive participants were aware of their condition, only 4 of 21 (19%) received treatment in the past, and 2 of 4 (50%) failed to achieve treatment goals, as assessed by HCV PCR. Conclusions: Our data indicate a high prevalence of HCV infection among homeless PWUDs. Importantly, despite relatively high awareness of HCV status in this population, we found strikingly low access to care. These findings motivate novel interventional approaches targeted at improving patient access, and compliance among homeless PWUDs, in an effort to reduce HCV transmission.
Visual imagery imitation skills and cognitive functions in patients with Schizophrenia
Authors: Tanaka Makoto , Osanai Takao , Kato Takuhiko , Ogasawara Hisako , Wada Kazumaru 
Published: May 2022

Background/Objectives Visual demonstration by occupational therapists is very common in psychiatric treatment, however, some patients with schizophrenia could not imitate the actions despite the absence of any physical impairments. Therefore, the purpose of this study was to identify how cognitive functions such as attention and cognitive processes in the imitation process is necessary and how these processes were related to the ability to convert this into action (imitation) in patients with schizophrenia. Method The participants were patients with schizophrenia with mean age 59.2 (± 11.3) years, 23 were men and 10 were women. The participants were tested for imitation ability and cognitive function, working memory, and motor imagery. Results Three subjects achieved full scores in the visual imitation test. However, the median of the total score was 10.0, with many subjects failing to imitate multiple tasks. Imitation learning is associated with duration of illness(t = −4.09, p = .000), mental health(t = −2.30, p = .029), and cognitive function such as the ability to retain visual information(t = −2.97, p = .006), and that these factors are interrelated. Conclusion To effectively promote imitation learning in patients with schizophrenia, occupational therapists need to establish teaching methods that make it easier for learners to retain visual information from the early stages of their illness.
Nasointestinal tube placement: Techniques that increase success
Authors: Taylor Stephen J , Sayer Kaylee , White Paul 
Published: May 2022

Background Delayed gastric emptying (DGE) is a major cause of undernutrition that can be overcome using nasointestinal (NI) feeding, but tube placement often fails. We analyse which techniques enable successful NI tube placement. Methods Efficacy of tube technique was determined at each of six anatomical points: Nose, nasopharynx-oesophagus, stomach-upper and -lower, duodenum part-1 and intestine. Results In 913 first NI tube placements, significant associations with tube advancement were found in the pharynx (head tilt, jaw thrust, laryngoscopy), stomach_upper (air insufflation, 10 cm or 20–30 cm flexible tube tip ± reverse Seldinger manoeuvre), stomach_lower (air insufflation, possibly flexible tip and wire stiffener) and duodenum part-1 and beyond part-2 (flexible tip and combinations of micro-advance, slack removal, wire stiffener or prokinetic drugs). Conclusion This is the first study to show what techniques are associated with tube advancement and the alimentary tract level they are specific to.
Anatomical Patterns of the Nasopalatine Canal and Incisive Foramen in an African Setting: A Cross-Sectional Study
Authors: Sarna Krishan , Estreed Merna A. , Sonigra Khushboo J. , Amuti Thomas , Opondo Florence , Kamau Martin , Ngeow Wei C. 
Published: May 2022

Study Design: Descriptive cross-sectional. Objective: To determine the morphology and morphometry of the nasopalatine canal (NPC) and incisive foramen (IF) in an African population. Methods: Measurements of the NPC and the IF were carried out on 150 Cone-Beam computed tomography (CBCT) scans. The maxillary bone thickness anterior to the NPC was measured at 3 levels. Independent t-test and Chi-square test were performed to determine the presence of sexual dimorphism. Results: The presence of one Stenson’s foramen was most prevalent. The mean length of NPC was 13.21 ± 3.25 mm with significantly longer canals in males. The most prevalent shape of NPC was cylindrical in sagittal view and a single canal in coronal view. The mean angulation of NPC was 118.42° to the horizontal plane. The average dimensions of the IF were 3.53 mm and 3.07 mm in the anteroposterior and mediolateral diameter, respectively, while the most common shape was round. The anterior maxillary bone was thicker in males and generally reduced in thickness from the anterior nasal spine superiorly towards the alveolar crest inferiorly. Conclusion: This study highlights the anatomical characteristics of the NPC and IF, with significant sexual dimorphism observed regarding the number of Stenson’s foramina, length of NPC, shapes of the NPC and IF, as well as alveolar bone thickness anterior to NPC.
Paper 06: The Effect of Anterior Glenoid Cartilage Defects on Anterior Glenohumeral Instability: A Biomechanical Study
Authors: Kawakami Jun , Henninger Heath , Knighton Tyler , Yamamoto Nobuyuki , Tashjian Robert , Itoi Eiji , Chalmers Peter 
Published: May 2022

Objectives: While it is well-known that a glenoid osseous defect of >25% glenoid width or 20% of the glenoid length critically destabilizes the shoulder, it is unclear whether glenoid cartilage defects contribute to the shoulder stability, and if so at what size defect the shoulder is critically destabilized. The purpose of this study was to determine the effect of incremental cartilage defect sizes on the anterior shoulder stability. We hypothesized that cartilage defects of equal to or greater than 25% of the glenoid width or 20% of the glenoid length will significantly the decrease the anterior shoulder stability ratio. Methods: This was a controlled laboratory study testing 12 fresh-frozen shoulders. Specimens were attached to a custom testing device in abduction and neutral rotation with 50N compression applied to the glenoid. The humeral head was translated 10 mm anteriorly, anteroinferiorly, and anterosuperiorly with conditions of intact cartilage and labrum and anterior cartilage defects of 3, 6, and 9 mm width. Translation force was measured continuously. Peak translation force divided by 50 N compression force was defined as the stability ratio. Data were analyzed using ANOVA tests. Results: In the anterior direction, the stability ratio decreased between intact cartilage (36±7%) and all defects 3-mm or larger (32±8%, p=0.023.) In the anteroinferior direction, the stability ratio decreased between intact cartilage (52±7%) and all defects 3-mm or larger (47±7%, P=0.006). In the anterosuperior direction, the stability ratio decreased between intact cartilage (36±4%) and all defects larger than 6-mm (32.6±4%, P = 0.006.) A 3-mm cartilage defect was equivalent to 10% of the glenoid width and 7% of the glenoid length. There were strong negative correlations between the glenoid cartilage defect size and the stability ratio in the anterior direction, the anteroinferior direction and the anterosuperior direction (r= -0.79, -0.63, and -0.58, respectively, P≤0.001). There were strong negative correlations between the ratio of glenoid cartilage defect size to the glenoid width and the stability ratio in all directions (r= -0.81, -0.63, and -0.61, respectively, P≤0.001.) Conclusions: An anterior cartilage defect of >3 mm or >10% of the glenoid width or 7% of the glenoid length significantly decreases anterior and anteroinferior stability and may require further treatment to restore stability. Cartilage defect size negatively correlates with stability.