bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing extracellular electron transfer through selective enrichment of Geobacter with Fe@CN modified carbon-based anode in microbial fuel cells
Authors: Cheng Xiao-Long , Xu Qiang , Yang Qian-Wen , Tian Rui-Rui , Li Biao , Yan Su , Zhang Xue-Ying , Zhou Jun , Yong Xiao-Yu 
Published: October 2022

Abstract
Microbial fuel cells (MFCs) have been demonstrated as a renewable energy strategy to efficiently recover chemical energy stored in wastewater into clean electricity by exoelectrogens through a combination of microbial metabolism and electrochemical processes, yet the limited power density limits their application. Here, Fe coped carbon and nitrogen (Fe@CN) nano-material was synthesized by direct pyrolysis of FeCl3 and urea, which was further decorated to fabricate Fe@CN modified carbon paper anode to improve the bioelectrochemical performance of MFCs. With a higher electrochemically active surface area, the Fe@CN modified anode was beneficial for enhancing microorganisms adhesion and extracellular electron transfer (EET). Accordingly, the MFC with Fe@CN modified anode (MFC-Fe@CN) successfully achieved a highest voltage output of 792.76 mV and a prolonged stable voltage output of 300 h. Interestingly, Geobacter species (15.41% abundance) was significantly enriched in the EABs of MFC-Fe@CN, while MFC-CP (unmodified carbon paper anode) favored the other exoelectrogens (Dysgonomonas and Comamonas). This work demonstrated the feasibility of development on anode catalysts for the elaboration of the catalytic principle about interface modification, which may contribute to the practical application of MFC in energy generation and wastewater treatment.
Analysis of Development Status and Function Features of Diabetes Health Management Apps
Authors: Duan Beibei , Liu Mengdi , Ma Cunhao , Liu Weiwei 
Published: October 2022

Abstract
Background: Using Diabetes-related Apps can effectively reduce the patients’ level of glucose and rehospitalization rate. However, due to the serious homogeneity of diabetes apps content and uneven function quality, medical staffs and patients do not know how to choose. This study aimed to understand the development status of diabetes health management Apps, analyze their functions and characteristics, and provide recommendations for further improvement or development of diabetes-related Apps.
Methods: In May 2022, diabetes-related apps were screened in ten major App markets, including Android and iOS system by using the keywords either Chinese or English. The apps that met the criteria were downloaded and their functions and characteristics were analyzed. Silberg scale was used to assess their information accountability.
Results: 90 diabetes-related apps were included, including 69 Chinese apps and 21 English apps. Almost all (97.8%) of which were developed by companies and commercial teams. Most of the apps (96.7%, 87/90) were targeted at people with diabetes, and only 3.3% were for type 1 and gestational diabetes. The total mean score of Silberg scale was 3.67±0.83. Among 28 functions, individual customized function and social support function are rare.
Conclusion: At present, the overall accountability quality of diabetes-related apps is low. The functions are insufficient, and the individual customized functions need to be further explored. In the future, it should be strengthen the diversity and individualization of diabetes-related apps, increase the development of special types of diabetes apps, and encourage medical staffs and patients to participate in the designment and development of Apps.
Categorizing 161 plant mitochondrial group II introns into 29 families of related paralogues finds only limited links between intron mobility and intron-borne maturases
Authors: Zumkeller Simon , Knoop Volker 
Published: October 2022

AbstractGroup II introns are common in the two endosymbiotic organelle genomes of plants. Chloroplasts harbor 22 positionally conserved group II introns whereas their occurrence in land plant mitogenomes is highly variable and specific for the seven major embryophyte clades: liverworts, mosses, hornworts, lycophytes, ferns, gymnosperms and flowering plants. Each plant group features “signature selections” of ca. 20–30 paralogues from a superset of altogether 105 group II introns meantime identified in embryophyte mtDNAs, suggesting massive intron gains and losses along the backbone of plant phylogeny. We report on systematically categorizing plant mitochondrial group II introns into “families”, comprising evidently related paralogues at different insertion sites, which may even be more similar than their respective orthologues in phylogenetically distant taxa. Including streptophyte algae extends our sampling to 161 and we sort 104 streptophyte mitochondrial group II introns into 25 core families of related paralogues evidently arising from retrotransposition events. Adding to discoveries of only recently created intron paralogues, hypermobile introns and twintrons, our survey led to further discoveries including previously overlooked “fossil” introns in spacer regions or e.g., in therps8pseudogene of lycophytes. Initially excluding intron-borne maturase sequences for family categorization, we added an independent analysis of maturase phylogenies and find a surprising incongruence between intron mobility and the presence of intron-borne maturases. Intriguingly, however, we find that several examples of nuclear splicing factors meantime characterized simultaneously facilitate splicing of independent paralogues now placed into the same intron families. Altogether this suggests that plant group II intron mobility, in contrast to their bacterial counterparts, is not intimately linked to intron-encoded maturases.
Kenyan palliative care providers’ and leaders’ perceptions of palliative care research needs and support to facilitate rigorous research
Authors: Cartmell KB , Doherty EA , Gikaara N , Ali Z , Qanungo S , Melikam ES , Powell RA 
Published: October 2022

Abstract
Background: Palliative care (PC) can reduce symptom distress and improve quality of life for patients and their families experiencing life-threatening illness. While the need for PC in Kenya is high, PC service delivery and research is limited. Qualitative research is needed to explore potential areas for PC research and support needed to enable that research. This insight is critical for informing a national PC research agenda and mobilizing limited resources for conducting rigorous PC research in Kenya.
Objectives: To explore perceptions of priority areas for PC research and support needed to facilitate rigorous research from the perspective of Kenyan PC providers and leaders.
Methods: Focus groups (FGs) were conducted in November and December of 2018 using a semi-structured interview guide. FGs were audio-recorded, transcribed, and analyzed using a thematic content analysis approach.
Results: Three FGs were conducted (n=22 participants). Eleven themes related to PC research emerged, including research on: 1) beliefs about death, disease, and treatment to inform PC; 2) awareness about PC, 3) integration of PC within the health system; 4) understanding caregiver experiences and needs; 5) community health volunteers (CHVs) and volunteer programs; 6) evaluation of costs and benefits of PC; 7) use of complementary and alternative medicine (CAM) in PC; 8) use of advanced diagnostics and extensive treatment in incurable disease; 9) other suggestions for research, 10) populations for whom PC research is needed; and 11) resources for enabling research.
Conclusions: Kenyan PC providers and leaders identified key areas requiring increased scientific inquiry and critical resources needed to enable this research. These findings can help to focus future PC research in Kenya and encourage funding agencies to prioritize the issues identified.
The Mycobiome of Bats in the American Southwest is Structured by Geography, Bat Species, and Behavior
Authors: K Patrick J , Winter Ara S. , Woodhams Douglas C. , Northup Diana E. 
Published: October 2022

Abstract
Bats are widespread mammals that play key roles in ecosystems as pollinators and insectivores. However, there is a paucity of information about bat-associated microbes, in particular their fungal communities, despite the important role microbes play in host health and overall host function. The emerging fungal disease, white-nose syndrome, presents a potential challenge to the bat microbiome and understanding healthy bat-associated taxa will provide valuable information about potential microbiome-pathogen interactions. To address this knowledge gap, we collected 174 bat fur/skin swabs from 14 species of bats captured in five locations in New Mexico and Arizona and used high-throughput sequencing of the fungal internal transcribed (ITS) region to characterize bat-associated fungal communities. Our results revealed a highly heterogeneous bat mycobiome that was structured by geography and bat species. Furthermore, our data suggest that bat-associated fungal communities are affected by bat foraging, indicating the bat skin microbiota is dynamic on short time scales. Finally, despite the strong effects of site and species, we found widespread and abundant taxa from several taxonomic groups including the genera Alternaria and Metschnikowia that have the potential to be inhibitory towards fungal and bacterial pathogens.
3D printing of foetal vascular rings: feasibility and applicability
Authors: Huang Jia , Wang Hao , Yang Yuanting , Chen Qian , Hu Jiaqi , Shi Hua , Zhou Qing 
Published: October 2022

Abstract
Background
Vascular rings(VRs) exhibit complex and diverse forms that are difficult to conceptualize using traditional two-dimensional (2D) schematic. Inexperienced medical students and parents who lack a medical technology background face significant challenges in understanding VRs. The purpose of this research is to develop three-dimensional (3D) printing models of VRs to provide new technical imaging support for medical education and parental consultation.
Methods
This study included 42 fetuses diagnosed as VRs. Foetal echocardiography, modeling and 3D printing were performed, and the dimensional accuracy of models was analyzed. The value of 3D printing in the teaching of VRs was analyzed based on comparing the test results before and after the teaching intervention of 48 medical students and the satisfaction survey. A brief survey was conducted to 40 parents to assess the value of the 3D printed model in prenatal consultations.
Results
Forty models of VRs were successfully obtained, which reproduced the anatomical shape of the VRs space with high dimensional accuracy. No differences in the prelecture test results were noted between the 3D printing group and the 2D image group. After the lecture, the knowledge of both groups improved, but the postlecture score and the change in the prelecture versus postlecture score were greater in the 3D printing group, and the subjective satisfaction survey feedback in the 3D printing group was also better (P < 0.05). Similar results were observed from the parental questionnaire, the vast majority of parents have an enthusiastic and positive attitude towards the use of 3D printed models and suggest using them in future prenatal consultations.
Conclusions
Three-dimensional printing technology providing a new tool for effectively displaying different types of foetal VRs. This tool helps physicians and families understand the complex structure of foetal great vessels, positively impacting medical instruction and prenatal counselling.
Knowledge of early gastric cancer screening among adults ≥45 years in China: Who, when, and how
Authors: He Xiaoci , Qian Wang , Zhao Shuping , Qi Wei 
Published: October 2022

Abstract
Objective
Gastric cancer remains the fifth most diagnosed cancer and the fourth leading cause of cancer-related death worldwide. A better understanding of gastric cancer or early screening is crucial in disease prevention. In our country, the understanding of gastric cancer is still relatively lacking. Howere, little is known about the knowledge of early gastric cancer screening, especially among the ≥ 45-year population in China. This study aimed to evaluate knowledge of early gastric cancer screening and associated factors in the population ≥ 45 years in Shijiazhuang, China, 2022.
Methods
A cross-sectional study was conducted in public places in Shijiazhuang, China, through the distribution of structured questionnaires. From 1 August 2022 to 10 August 2022, 1200 subjects over 45 were enrolled in the study. The descriptive and logistic regression analyses were performed using SPSS version 26.0.
Results
A total of 1053 respondents participated in the study with a response rate of 88%.Only 17.5% of respondents had good early gastric cancer screening knowledge. In terms of specific screening knowledge, 64.0% of participants agreed that gastroscopy is the gold standard for early gastric cancer screening(how). However, only 19.9% were aware of the starting age of early screening (when), and less than 50% correctly identified the target group (who) from the H. pylori infection population (lowest,20.5%) to individuals with gastric diseases (highest,47.6%). Independent factors related to higher screening knowledge included female sex(OR = 1.55, 95% CI = 1.01–2.38),higher education level(OR = 4.03, 95% CI = 2.68–6.06), being with a personal/family experience of gastric diseases(OR = 1.68, 95% CI = 1.12–2.52).
Conclusion
In China, people ≥ 45 years have poor knowledge about early gastric cancer screening, especially a lack of awareness of specific information, including starting age(when)and target group༈who༉. Sex, education level, and personal/family experience of gastric diseases were found to be independent predictors of the early screening knowledge of respondents. Therefore, males aged 45 years and older, those with low education levels, and those without a personal/family experience of gastric diseases could be a key group in early screening education.
A Study of Manufacturing and Inventory Strategies in Close-Loop Supply Chain: A Two-Phase News-vendor Model with an Extended Warranty
Authors: Jalapathy P , M Mubashir Unnissa 
Published: October 2022

Abstract
Closed-loop supply chain procedures provide manufacturers with a competitive advantage over their competitors. Also, the supply chain involves a manufacturer and customers, in which the manufacturer produces and sells products from the manufacturing market. Interestingly, combining forward and reversal strategies presents challenges on both the on-demand and supply sides of the market. When customers purchase products, they are uncertain about the quality of the product, and the manufacturer offers a warranty to assure the customers about the reliability and quality of the products. This paper presents a two-phase News-vendor framework for warranted and non-warranted products with inventory carryover to describe the best manufacturing and re(manufacturing) procedures. The demand is modeled in stochastic nature with one dimensional extended warranty for both new and reman products. Two scenarios are considered to demonstrate the importance of providing an extended warranty. Finally, the numerical analysis concludes that the expected profit affects the manufacturer’s influence when providing a warranty and graphical results reveal that offering an extended warranty and lowering holding expenditure enhances the manufacturer’s expected total profit over two phases.
The Burden Assessment Scale in Spanish family caregivers of people diagnosed with Borderline Personality Disorder
Authors: García-Alandete Joaquín , Fernández-Felipe Isabel , Fonseca-Baeza Sara , Fernández Irene , Rodríguez Sandra Pérez , Marco José H. , Guillén Verónica 
Published: October 2022

Abstract

Bakground.
Caregiving is a strong source of stress and leads the family caregiver to experience the burden of being responsible for the care of a severely mentally ill family member. The Burden Assessment Scale (BAS) assesses burden in family caregivers. This study aimed to analyze the psychometric properties of the BAS in a sample of family caregivers of people diagnosed with Borderline Personality Disorder (BPD).
Methods.
Participants were 233 Spanish family caregivers (157 women and 76 men aged between 16–76 years old, M = 54.44, SD = 10.09) of people diagnosed with BPD. The BAS, the Multicultural Quality of Life Index, and the Depression Anxiety Stress Scale-21 were used.
Results.
An exploratory analysis resulted in a three-factor 16-item model (Disrupted Activities; Personal and Social Dysfunction; Worry, Guilt, and Being Overwhelmed) with an excellent fit (χ²(101) = 56.873, p = 1.000, CFI = 1.000, TLI = 1.000, RMSEA = .000, SRMR = .060), good internal consistency (ω = .93), a negative correlation with quality of life, and a positive correlation with anxiety, depression, and stress.
Conclusion.
The model obtained for the BAS is a valid, reliable, and useful tool for assessing burden in family caregivers of relatives diagnosed with BPD.
Diagnostic accuracy of Left atrial function and strain for differentiating between acute and chronic myocardial infarction
Authors: Jiang Xiaofeng , Yan Yi , Yang Zhi , Wen Miao , Long Yitian , Fu Bing , Jiang Jian 
Published: October 2022

Abstract
Background
The left atrial strain and strain rate in patients with myocardial infarction (MI) were measured using the cardiac magnetic resonance tissue tracking (CMR-TT) technique, and its usefulness in the quantitative assessment of myocardial infarction for differentiating between acute and chronic myocardial infarction was assessed.
Methods
Consecutive 36 AMI patients and 29 CMI patients who underwent CMR were retrospectively analyzed as well as 30 controls. By analyzing the strain from long and short left ventricular view cines from CMR-TT, the left atrial and ventricular functions were measured. Receiver operating characteristic(ROC) analysis was used to test the diagnostic accuracy of the CMR-TT strain parameters in distinguishing acute from chronic myocardial infarction.
Results
Participants in both AMI and CMI demonstrated decreased LA reservoir function, conduit function, and LA booster pump dysfunction as compared to the controls. The LA strain was more sensitive than the LV global strain for determining the stage of MI. Of all the LA strain parameters measured, SRa produced the best areas under the ROC curve (AUC) of 0.879 in demonstrating distinction between acute and chronic myocardial infarction. The LV strain and LA functional parameters showed the largest significant differences between chronic myocardial infarction and normal (P < 0.001, respectively), while there was no difference between AMI and normals.
Conclusions
CMR-TT-derived LA strain is a promising and robust tool for demonstrating impaired LA mechanics and quantifying LA dynamics, both of which have high sensitivity and specificity in the differential diagnosis of acute versus chronic myocardial infarction, and their use in clinical application is thus worth promoting.
MLKL Deficiency Attenuated Hepatocyte Oxidative DNA Damage by Activating Mitophagy to Suppress Macrophage cGAS-STING Signaling During Liver Ischemia and Reperfusion Injury.
Authors: Rao Zhuqing , Xu Jian , Wu Dongming , Zhou Shun , Hu Haoran , Li Fei , Guan Zhu , Zhan Xinyu , Gao Yiyun , Wang Ping 
Published: October 2022

Abstract
Mixed-lineage kinase domain-like protein (MLKL)-mediated necroptosis has been implicated in aggravating liver ischemia and reperfusion (IR) injury. However, the precise role and mechanism of MLKL in regulating oxidative DNA damage of hepatocytes and subsequent activation of macrophage stimulator of interferon genes (STING) signaling remains unclear. In this study, we investigated the role of MLKL in regulating the interplay between hepatocyte injury and macrophage pro-inflammatory responses during liver IR injury. We found that IR increased MLKL expression in liver tissues of wild type (WT) mice. MLKL knockout (KO) attenuated liver IR injury and suppressed the activation of cGAS-STING signaling in intrahepatic macrophages, which was abrogated by STING activation with its agonist. Mechanistically, IR induced oxidative DNA damage in hepatocytes, leading to cGAS-STING activation in macrophages, which was suppressed by MLKL KO. Moreover, increased PTEN-induced kinase 1 (PINK1)-mediated mitophagy contributed to reduced oxidative DNA damage in hepatocytes and subsequent decreased activation of STING signaling in macrophages in MLKL KO mice. Our findings demonstrated a non-canonical role of MLKL in the pathogenesis of liver IR. MLKL deficiency significantly promoted PINK1-mediated mitophagy activation to inhibit oxidative DNA damage in hepatocytes, which in turn suppressed macrophage cGAS-STING activation and inflammatory liver IR injury.
A Comparison of Special Intrauterine Balloons and Intrauterine Contraceptive Devices in the Treatment of Intrauterine Adhesions
Authors: Zhuang Lin-Lin , Wang Kai , Shen Hai-Lan , Lin Jia-Hui , Lu Ye , Luo Zhen-Yu , Wang Wen-Rong 
Published: October 2022

Abstract
Purpose
This study aimed to compare the efficacy of a special kind of intrauterine balloon (IUB) and that of an intrauterine contraception device (IUD) for patients with IUAs after transcervical resection of adhesion (TCRA).
Methods
In this retrospective cohort study, after TCRA, 31 patients received a special IUB, and 38 patients received an IUD. The Fisher exact test, logistic regression method, Kaplan–Meier method and Cox proportional hazards regression model were used for statistical analysis. A two-sided value of P < 0.05 was considered statistically significant.
Results
The readhesion rate significantly differed between the IUB group and IUD group, at 15.39% and 54.06%, respectively (P = 0.002). For recurrent moderate IUA, patients in the IUB group had lower scores than patients in the IUD group (P = 0.035). There was a significant difference in the intrauterine pregnancy rate of IUA patients in the IUB group and IUD group after treatment, with rates of 55.56% and 14.29%, respectively (P = 0.015).
Conclusion
Patients in the special IUB group had better outcomes than those in the IUD group, which has certain guiding significance for clinical work.