bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRAKTIK SERBU DI APLIKASI BUKALAPAK DALAM PERSPEKTIF HUKUM EKONOMI SYARIAH
Authors: Cipta Sanzani Aditiya 
Published: December 2022

This study aims to find out sharia economic law against the practice of Buying Pulses for Serbu in Bukalapak application. This study uses descriptive research method of analysis with case study approach. In addition, the type of data used in this study is qualitative data. The results of the analysis showed that: (1) Beli Pulsa Untuk Serbu is done by the way the buyer selecting the goods which there is indeed in certain sessions and periods. Then the invaders are required to approve the refund in the form of pulse. Raids can only be carried out once. The draw is conducted after the period ends. The draw is conducted in privately. The announcement of the winner can be seen on the history of Serbu Seru and bukalapak official website. The prize submission is submitted a maximum of 30 working days. 2) In the practice of Beli Pulsa Untuk Serbu more contains mudharat-his juxtaposed to-maslahat, then the practice of Beli Pulsa Untuk Serbu in Bukalapak Application law is haraam. Penelitian ini bertujuan untuk mengetahui Hukum Ekonomi Syariah terhadap praktik Beli Pulsa Untuk Serbu di aplikasi Bukalapak. Penelitian ini menggunakan metode penelitian deskriptif analisis dengan pendekatan studi kasus. Selain itu jenis data yang digunakan pada penelitian ini adalah data kualitatif. Hasil analisis menunjukkan bahwa: (1) Beli Pulsa Untuk Serbu dilakukan dengan cara penyerbu memilih barang yang terdapat pada sesi dan periode tertentu. Kemudian penyerbu diwajibkan untuk menyetujui pengembalian dana dalam bentuk pulsa. Penyerbuan hanya dapat dilakukan satu kali per-sesi-nya. Pengundian dilakukan setelah periode berakhir. Pengundian dilakukan secara tertutup. Pengumuman pemenang dapat dilihat pada riwayat Serbu Seru dan website resmi Bukalapak. Penyerahan hadiah diserahkan maksimal 30 hari kerja. 2) Dalam praktik Beli Pulsa Untuk Serbu lebih banyak mengandung mudharat-nya dibandingkan ke-masalahatan-nya, maka praktik Beli Pulsa Untuk Serbu di Aplikasi Bukalapak hukumnya adalah haram.
Fa’āliyah Mind Mapping Li Tarqiyah Natāij Ta’allum Al Thalabah Fī Mādah Al Nahwi
Authors: Nur Ifa Rodifah Nur , Ahmad Fairuz Subakir , Husna Haulia , Tailakh Nahla 
Published: December 2022

Pengajaran bahasa asing membutuhkan metode dan strategi yang efektif, mind mapping merupakan salah satu metode pengajaran yang efektif, sehingga peneliti menggunakan metode ini untuk mengajarkan nahwu pada santriwati kelas 3. Selain pembelajaran di dalam kelas kegiatan latihan, pembiasaan, dan pengulangan di luar kelas juga sangat diperlukan guna menunjang keberhasilan pembelajaran. Penelitian ini bertujuan untuk mengetahui efektivitas penerapan Mind Mapping dalam meningkatkan hasil belajar nahwu siswi kelas 3 Pondok Modern Darussalam Gontor Putri kampus I. Jenis penelitian ini adalah penelitian tindakan kelas, dengan jumlah sampel sebanyak 39 siswi. Pelaksanaan penelitian terdiri dalam dua siklus, untuk setiap siklus terdapat empat langkah yaitu perencanaan, pelaksanaan, observasi dan refleksi. Hasil penelitian ini menyatakan bahwa penerapan Mind Mapping efektif untuk meningkatkan hasil belajar nahwu pada siswi kelas III F Pondok Modern Darussalam Gontor Putri kampus 1, persentase keberhasilan siswi sebelum penerapan mind mapping adalah 26% dari 39 siswa, presentase keberhasilan ini naik pada siklus pertama yaitu 76%, dan pada siklus kedua naik menjadi 85%.
Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment
Authors: Liang Xiujie , Aranyi Tamas , Zhou Jianfu , Guan Yuting , Hu Hailong , Liu Hongbo , Susztak Katalin 
Published: December 2022

Significance Statement
Epigenetic changes have been proposed to mediate nephron endowment during development, a critical determinant of future renal disease development. Hydroxymethyl cytosine, an epigenetic modification important for gene regulation, is abundant in the human kidney, but its physiologic role and the role of DNA demethylase enzymes encoded by the Tet1, Tet2, or Tet3, which mediate cytosine hydroxymethylation, are unclear. By genetically deleting Tet1, Tet2, or Tet3 in nephron progenitors in mice, the authors showed that combined Tet2 and Tet3 loss in nephron progenitors cause defective kidney development, leading to kidney failure and perinatal death. Tet2 and Tet3 deletion also caused an alteration in demethylation and expression of genes critical for nephron formation. These findings establish that Tet2- and Tet3-mediated cytosine hydroxymethylation in nephron progenitors plays a critical role in nephron endowment.

Background
Nephron endowment is a key determinant of hypertension and renal disease in later life. Epigenetic changes have been proposed to mediate fetal programming and nephron number. DNA cytosine methylation, which plays a critical role in gene regulation, is affected by proteins encoded by the ten-eleven translocation (TET) DNA demethylase gene family (Tet1, Tet2, and Tet3), but the roles of TET proteins in kidney development and nephron endowment have not been characterized.

Methods
To study whether epigenetic changes—specifically, active DNA hydroxymethylation mediated by Tet1, Tet2, and Tet3—are necessary for nephron progenitor differentiation and nephron endowment, we generated mice with deletion of Tet1, Tet2, or Tet3 in Six2-positive nephron progenitors cells (NPCs). We then performed unbiased omics profiling, including whole-genome bisulfite sequencing on isolated Six2-positive NPCs and single-cell RNA sequencing on kidneys from newborn mice.

Results
We did not observe changes in kidney development or function in mice with NPC-specific deletion of Tet1, Tet2, Tet3 or Tet1/Tet2, or Tet1/Tet3. On the other hand, mice with combined Tet2 and Tet3 loss in Six2-positive NPCs failed to form nephrons, leading to kidney failure and perinatal death. Tet2 and Tet3 loss in Six2-positive NPCs resulted in defective mesenchymal to epithelial transition and renal vesicle differentiation. Whole-genome bisulfite sequencing, single-cell RNA sequencing, and gene and protein expression analysis identified a defect in expression in multiple genes, including the WNT-β-catenin signaling pathway, due to a failure in demethylation of these loci in the absence of Tet2 and Tet3.

Conclusions
These findings suggest that Tet2- and Tet3-mediated active cytosine hydroxymethylation in NPCs play a key role in kidney development and nephron endowment.
Co-concevoir localement les outils de l’accompagnement du changement pour engager conjointement conseillers et éleveurs dans la transition.
Authors: LACOMBE Camille , GRESSIER Estelle , COUIX Nathalie 
Published: December 2022

Le projet salsa avait pour objectif d’engager la transition agroécologique des élevages ovin-lait de l’AVEM, via la mobilisation d’un outil de diagnostic global des fermes, qui permettrait d’identifier les bonnes pratiques et les leviers d’action à mettre en œuvre pour améliorer les performances agroécologiques des fermes. La co-conception locale et chemin-faisant de cet outil au cours du projet a conduit à adapter l’outil à ses futures situations d’utilisation dans les fermes. Petit à petit, la logique initiale d’utilisation « prescriptive » a évolué vers une logique d’accompagnement des projets individuels des éleveurs, mobilisant l’outil simultanément comme support d’animation, de comparaison, de simulation ou de suivi des changements individuels, au sein de petits groupes locaux de pairs. Au cours de cette évolution, la participation et la place des éleveurs dans le conseil et l’accompagnement de leurs pairs s’est transformée, et l’activité de conseil a évolué au sein de l’AVEM.
Features of the clinical course and prognosis of tongue cancer in young women
Authors: Kropotov M. A. , Yakovleva L. P. , Safarov D.  A. , Saprina O. A. , Peshko D. A. , Khodos A.  V. 
Published: December 2022

Introduction. In recent times, changes in epidemiology of tongue cancer have been observed. morbidity among nonsmoking and non-abusing alcohol young women have been rising. Currently, etiology and pathogenesis of tumor development in this nosological group are unclear and require detailed analysis of epidemiologic and clinical data.Aim. To analyze the clinical material on the incidence of tongue cancer among young women (under 45 years old) over a 10-year period and assess the prevalence of this pathology in this group, the methods of treatment and reconstruction used, and determine the prognosis.Materials and methods. The study included 68 female patients with squamous cell carcinoma of the tongue who received treatment between 2010 and 2020. mean age was 36.8 years (between 18 and 45 years; median – 39 years). None of the patients had history of alcohol abuse or smoking. In 32 (47.1 %) patients, primary diagnosis was made at stages I–II, in 36 (52.9 %) at stages III–Iv.Results. In the last 10 years, a trend towards increased morbidity of tongue cancer among young women have been observed. In 2010, 2 cases of the disease were detected, in 2019–13, in 2020–14. mean follow-up duration was 40 months (median 32 months). Overall 5-year survival in this period was 72.5 ± 6.5 %, recurrence-free 5-years survival was 66.5 ± 6.6 %. Conclusion. Increase on tongue cancer morbidity among young non-smoking women is a new epidemiological trend worldwide. Etiological and pathogenetic factors of this trend have not been studied and require large multicenter studies for obtaining statistically significant results. Early medical resource utilization in this social group allows to perform adequate surgical intervention but requires the head and neck tumor specialist to pay attention to reconstructive surgery, quality and early patient rehabilitation allowing to preserve high quality of life, capacity for work and social activity.
Radiotherapy for cutaneous squamous cell carcinoma: current standards and outlooks
Authors: Gevorkov A. R. , Boyko A. V. , Polyakov A. P. , Chernichenko A. V. , Gerasimov V. A. , Meshcheryakova I. A. , Kaprin A. D. 
Published: December 2022

Cutaneous squamous cell carcinoma accounts for 20 % of all malignant non-melanoma skin tumors, which is one of the most common cancers worldwide. Antitumor treatment is usually very effective: cure rate reaches 90 %, while local recurrence rate is 25 %. The main treatment option for primary skin cancers is surgery. The most significant risk factors for locoregional recurrence include tumor location (head and neck), size (>2 cm), depth of invasion (>4 mm), tumor differentiation grade, perineural invasion, immune system disorders (immunosuppression), severe concomitant diseases, and previous treatment.In patients with advanced cutaneous squamous cell carcinoma, 1-year, 2-year, and 3-year survival rates are 50–80, 30–35 and 15–16 %, respectively. Radiotherapy is a radical treatment option that increases the 5-year survival rate to 90 % and ensures good cosmetic results in 80 % of cases. There are 3 main variants of radiotherapy for cutaneous squamous cell carcinoma: sole radiotherapy according to a radical program, adjuvant radiotherapy in combination with surgery, and palliative radiotherapy. most frequently, radiotherapy is used as part of adjuvant postoperative treatment and is not initially considered as a sole conservative treatment for cutaneous squamous cell carcinoma patients below 45 years of age with resectable tumors, especially high-risk tumors. palliative radiotherapy is an affordable and effective method for combating painful symptoms; moreover, it often provides long-term local control.
Ranking Earthquake Sources Using Spatial Residuals of Seismic Scenarios: Methodology Application to the 1909 Benavente Earthquake
Authors: de Pro-Díaz Yolanda , Vilanova Susana , Canora Carolina 
Published: December 2022

ABSTRACTHistorical earthquakes are of major importance in the analysis of seismic hazards, in particular for stable continental regions. In this article, we propose a methodology that uses seismic scenarios to provide constraints on the location of the seismic source of historical earthquakes. Our methodology involves generating seismic scenarios for the proposed seismic sources and comparing the results to the observed intensity field of the earthquake. To avoid the bias related to strongly heterogeneously distributed datasets, we focus on data points that are useful in discriminating between competing ruptures. These data are identified by the spatial patterns of residuals between seismic scenarios produced for each source. We apply this methodology to a test event—the 1999 Athens earthquake—for which both the magnitude and location are constrained by independent data, and to the 1909 Benavente earthquake, for which the magnitude is constrained by seismological studies, but the location is uncertain due to the very poor azimuthal coverage available. Within its application limits, the proposed methodology was capable of identifying the source of the Athens earthquake amongst different ruptures located few kilometers apart. The analysis performed for the 1909 Benavente earthquake suggests that the eastern strand of the lower Tagus Valley fault zone is the most likely seismic source for earthquake, amongst those proposed in the literature.
An Exploration of Student Satisfaction with Online Learning: A Systematic Review
Authors: Muhibbin Maulana Arif , Wulandari Primatia Yogi , Andriani Fitri , Adzim Afa Fauzul 
Published: December 2022

Abstrak: Kepuasan belajar online merupakan konstruk yang dapat digunakan untuk mengevaluasi keefektifan layanan pembelajaran online. Tujuan penelitian ini untuk mengeksplorasi faktor-faktor kepuasan belajar online siswa. Sistematika literature review ini menganalisis 34 jurnal yang dikumpulkan dari dua situs, yaitu Google Scholar dan Semantic Scholar. Pada bagian pertama studi ini didiskusikan isu akademik pembelajaran online, kemudian model kepuasan belajar online yang digunakan para peneliti, dan terakhir menjelaskan prediktor yang dapat mempengaruhi kepuasan belajar online siswa. Hasil analisis menunjukkan bahwa faktor eksternal yang paling signifikan adalah learner content dan interaksi guru dengan siswa. Oleh karena itu, untuk meningkatkan kepuasan belajar siswa, guru diharapkan dapat menyajikan materi digital yang menarik serta meningkatkan kualitas komunikasi yang positif dikelas virtual.Â Abstract:Â Online learning satisfaction can be used to assess how well online learning programs work. This research can help education professionals in their efforts to develop adaptive online learning in dealing with future educational disruptions and challenges through the analysis of various literatures. This systematic literature review explored 34 journals from two sites: Google Scholar and Semantic Scholar. The first part of this study discusses the academic issue of online learning, the second section describes the online learning satisfaction model used by the researchers, and the last part describes the predictors that can affect students' online learning satisfaction. Learner content interaction and teacher-student interactions are the most primary external determinants on online learning satisfaction, according to the analysis' findings. Therefore, teachers are expected to be able to deliver engaging digital contents and enhance positive communication in online setting to increase studentsâ€™ learning satisfaction.
Peningkatan Kompetensi Konseling Ringkas Berfokus Solusi bagi Konselor SMK dan SMA
Authors: Ramli M , Hidayah Nur , Fauzan Lutfi 
Published: December 2022

The purpose of the activity is to improve the competence of counselors in Batu City Vocational High Schools and High Schools in implementing concise solution-focused counseling for solving problems faced by students. The training is carried out using a structured learning approach. To achieve this goal, a brief solution-focused counseling training was conducted for high school and vocational high school counselors in Batu City with a structured learning approach through the stages of fostering good relations, modeling, roleplaying, giving feedback, and assigning assignments. In general, the results of the training show that there is an increase in the competence of the trainees in the application of solution-focused concise counseling to help counselees achieve the expected goals in finding solutions to the problems they face.Tujuan kegaiatan untuk meningkatkan kompetensi konselor SMK dan SMA Kota Batu dalam menerapkan konseling ringkas berfokus solusi bagi penyelesaian masalah yang dihadapi siswa. Pelatihan dilakukan dengan pendekatan pembelajaran terstruktur (structured learning approach). Untuk mencapai tujuan tersebut dilakukan pelatihan konseling ringkas berfokus solusi kepada konselor SMA dan SMK Kota Batu dengan pendekatan belajar terstruktur melalui tahapan pembinaan hubungan baik, pemodelan, permainan peran, pemberian balikan, dan pemberian tugas. Secara umum, hasil pelatihan menunjukkan bahwa ada peningkatan kompetensi para peserta pelatihan dalam penerapan konseling ringkas berfokus solusi untuk membantu para konseli mencapai tujuan yang diharapkan dalam menemukan solusi pengatasan masalah yang dihadapi.
Early and long-term neurological complications of chemotherapy in oncology (literature review)
Authors: Vykhovanets N.  Yu. , Alyoshechkin P.  A. , Tomash L.  A. , Shevchenko A.  S. , Krasnyanskaya L.  A. , Shulik A.  I. 
Published: December 2022

An analysis of the clinical manifestations of complications caused by the toxic effect of chemotherapeutic drugs used in the treatment of malignant neoplasms was carried out. The variety of clinical symptoms that develop against the background of chemotherapy for malignant neoplasms leads to difficulties in differential diagnosis of a primary neurological disease and the identification of complications during treatment. The severity of these complications depends on a number of factors, including the drug used, its dosage and duration of use, the use of various methods of combination therapy and radiation methods, as well as the presence of comorbid pathology in patients. A clear understanding of the mechanisms of development of neurotoxicity and timely diagnosis of such conditions is a priority task of modern clinical medicine Modern methods of treating patients with malignant neoplasms should be based on a multidisciplinary medical approach, including a set of measures to prevent unwanted toxic effects of treatment, stratify individual mortality risks and develop methods of rehabilitation and medical examination.
Echocardiographic Predictors of Ventricular Tachyarrhythmias in Patients With Cardioverter-Defibrillator Implanted for Primary Prevention of Sudden Cardiac Death. Results From a two-Year Prospective Follow-up Study
Authors: Ilov N. N. , Boytsov S. A. , Stompel D. R. , Palnikova O. V. , Nechepurenko A. A. 
Published: December 2022

Aim To compare variables of transthoracic EchoCG for determining echocardiographic predictors and their prognostic role in the development of persistent paroxysmal ventricular tachyarrhythmias (VT) in patients with ischemic CHF who had been implanted with a cardioverter defibrillator (CD) for primary prevention of sudden cardiac death.Material and methods This single-site prospective study included 176 patients with CHF of ischemic origin aged 58.7±7.4 years with a left ventricular ejection fraction (LV EF) of 30 % [25; 34] % who had been implanted with CD. The follow-up duration was 24 months. The primary endpoint was a newly developed persistent paroxysm of VT (duration ≥30 sec) detected in the “monitored” VT area or a VT paroxysm that required electric treatment. The echocardiographic picture was evaluated by 28 variables. Statistical analysis was performed with the c2, Fisher’s, and Mann—Whitney tests, and the one-factor logistic regression (LR). Prognostic models were developed with a multifactorial LR. The model accuracy was evaluated by 4 metrics: area under the ROC (AUC), sensitivity, specificity, and diagnostic efficacy.Results The primary endpoint was observed in 60 (34 %) patients. Mean time to a persistent VT episode was 19.2±0.8 months (95 % confident interval (CI): 17.5–20.8). Superior-inferior dimensions of the right and left atria (RA and LA, respectively) and the left atrial volume (LAv) were independent predictors for VT. The odds of VT development in patients of the study cohort increased with RAl ≥4.5 cm (odds ratio (OR), 1.6; 95 % CI: 1.4–1.9; р=0.03), LAl ≥5.5 cm (OR, 2.5; 95 % CI: 1.01–6.1; р=0.04), LAv ≥95 ml (OR, 3.2; 95 % CI: 1.3–17.5; р=0.01). A comprehensive analysis of echocardiographic variables proved the prognostic potential of LAv that was linearly associated with the development of VT. The metrics of the best prognostic model were AUC 0.7±0.07 with 95 % CI: 0.54–0.83; specificity, 20.9 %; sensitivity, 95.7 %; and diagnostic efficacy, 47 %.Conclusion This study allowed evaluation of capabilities of transthoracic EchoCG for predicting the probability of VT in patients with CHF of ischemic origin and reduced LV EF. It was shown that linear and volumetric atrial dimensions could be used for stratification of risk of VT and for determining the tactics for primary prevention of sudden cardiac death in this patient category.
Harmony of religion and culture: fiqh munākahat perspective on the Gayo marriage custom
Authors: Santoso Dri , Jafar Wahyu Abdul , Nasrudin Muhamad , Asmara Musda , Fauzan Fauzan 
Published: December 2022

This study aimed to describe the established harmony between religion and culture within the traditional Gayo marriage custom. In addition, it determined whether the blending[SM1] of religion and culture in traditional Gayo marriages adheres to fiqh munākahat. This study was descriptive and qualitative field research using the sociological juridical approach. Interviews and documentation were used as data collection methods. Meanwhile, to identify informants, researchers employed a purposive sampling technique. The important finding of this study was that in traditional Gayo marriages, religion and culture are harmonized appropriately and without coercion. The acculturation of fiqh munākahat evidences harmonization: ta'aruf (introduction), khitbah (proposal), marriage advice, discussions, i'lanu nikah (marriage announcement), and hospitality. The acculturation of the fiqh munākahat concept is found in the procession of the risik kono (introduction of the bride and groom's family), the munginte (proposal), the beguru (giving advice), the betelah (discussion), the segenap and begenap (discussion and family), the mah bai (accompanying the groom) and mah beru (accompanying the bride), mah kero opat ingi (carrying rice for four days) and tanag kul (a visit to the bride's house). Moreover, only two of the five Gayonese marriage customs adhere to the fiqh munākahat: ango/juelen (patrilineal) and kuso now (to and fro) marriages. In contrast, engagement marriages (matrilineal), Naik (eloping) and mah tabak (marriage submission) are not in line with fiqh munākahat.