bluuebunny/crossref_metadata_2025_split huggingface dataset:
Placental pathology in sudden intrauterine death (SIUD) in SARS-CoV-2-positive oligosymptomatic women
Authors: Horn Lars-Christian , Krücken Irene , Hiller Grit Gesine Ruth , Niedermair Maria , Perac Kristina , Pietsch Corinna , Höhn Anne Kathrin 
Published: June 2022

Abstract
Background
Pregnant women are also susceptible to SARS-CoV-2. Although an infection of the placenta may be rare, pregnancy may occasionally be affected by intrauterine failure. The knowledge of placental morphology on sudden intrauterine demise is still limited.

Methods
Fetal and placental tissue of two cases of sudden intrauterine death in the second trimester were analysed morphologically and by immunohistochemistry. One case was evaluated by RT-PCR.

Results
Both mothers were tested positive for the Alpha variant of SARS-CoV-2 but were oligosymptomatic for COVID-19. Unexpected sudden intrauterine death (SIUD) occurred at 15 + 2 and 27 + 3 weeks of gestation. One fetus demonstrated an intrauterine growth restriction. No malformations nor inflammatory changes were observed in either fetus on autopsy. In contrast to the placentas, the fetal tissue was negative for SARS-CoV-2 on immunohistochemical and RT-PCR analyses. Macroscopically, the placentas showed an increased consistency with a white, reticular cutting surface covering about 95% of the whole placenta. Only very focal histiocytic chronic intervillositis was noted histologically. Massive perivillous fibrin deposits with extensive necroses of the villous trophoblast were present in more than 90% of the placental tissue. Immunohistochemical staining was strong and diffusely positive for SARS-CoV-2 in the villous trophoblast and rarely within the villous stromal cells. Placental SARS-CoV-2 infection was confirmed by RT-PCR.

Conclusion
Sudden intrauterine death may occur in mothers who are oligosymptomatic for COVID-19. Acute placental failure is responsible for SIUD, demonstrated by massive perivillous fibrin deposits and extensive necroses of the villous trophoblast with SARS-CoV-2-positivity based on immunohistochemical staining and RT-PCR. Detailed histopathological examination of placental and fetal tissue is mandatory to verify SARS-CoV-2 and to evaluate the pathogenesis and functionality of this disease.
Influence of the levonorgestrel-releasing intrauterine system on the risk of breast cancer: a systematic review
Authors: Zürcher Aline , Knabben Laura , Janka Heidrun , Stute Petra 
Published: June 2022

Abstract
Purpose
The intention of this systematic review was to analyze the literature on breast cancer (BC) and the use of the levonorgestrel-releasing intrauterine system (LNG-IUS).

Methods
The literature was searched in Medline, Embase, Cochrane Library, CINAHL, Web of Science and ClinicalTrials.com and included search terms related to breast cancer and LNG-IUS. After elimination of duplicates, 326 studies could be identified and were assessed according to inclusion and exclusion criteria. In the end, 10 studies met the defined criteria and were included in the systematic review.

Results
6 out of the 10 selected studies were cohort studies, three were case–control studies and one a systematic review/meta-analysis. 6 found a positive association between BC and the use of LNG-IUS. One study only found an increased risk for invasive BC in the subgroup of women aged 40–45 years. In contrast, three studies showed no indication of a higher BC risk.

Conclusion
The results imply an increased BC risk in LNG-IUS users, especially in postmenopausal women and with longer duration of use. Positive effects of the LNG-IUS such as reduced risks for other hormonal cancers have been observed, were, however, not focus of this systematic review. The heterogeneity of the analyzed studies and vast number of confounding factors call for further investigations in this issue. Patients should be advised according to their individual risk profile and hormone-free alternatives may be considered for women with a history of BC.
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation
Authors: Shahraki Abdolrazagh Hashemi , Tian Runxia , Zhang Chongxu , Fregien Nevis L. , Bejarano Pablo , Mirsaeidi Mehdi 
Published: June 2022

AbstractPurposeAlpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models.MethodsWe evaluated the anti-inflammatory effects of α-MSH on two different in vitro sarcoidosis models (lung-on-membrane model; LOMM and three-dimensional biochip pulmonary sarcoidosis model; 3D-BSGM) generated from NBECs and an in vivo sarcoidosis mouse model.ResultsTreatment with α-MSH decreased inflammatory cytokine levels and downregulated type I interferon pathway genes and related proteins in LOMM and 3D-BSGM models. Treatment with α-MSH also significantly decreased macrophages and cytotoxic T-cells counts in a sarcoidosis mice model.ConclusionOur results confirm the direct role of type I IFNs in the pathogenesis of sarcoid lung granulomas and highlight α-MSH as a potential novel therapeutic agent for treating pulmonary sarcoidosis.Graphical Abstract
A family cluster of schistosomiasis acquired in Solenzara River, Corsica (France) — Solenzara River is clearly a transmission site for schistosomiasis in Corsica
Authors: Wellinghausen Nele , Moné Hélène , Mouahid Gabriel , Nebel Axel , Tappe Dennis , Gabriel Martin 
Published: June 2022

Abstract
We report a patient with urogenital schistosomiasis and three cases of subclinical infection within one family acquired from Solenzara River, Corsica, in 2019. Our cases confirm that transmission of schistosomiasis in Corsica is ongoing and has been extended from the Cavu River to the Solenzara River. Solenzara River is clearly a transmission site for schistosomiasis in Corsica. Public health efforts are recommended to uncover and prevent further cases.
Distribution of Kudoa thyrsites (Cnidaria, Myxozoa) myoliquefactive stages in Northeast Atlantic mackerel (Scomber scombrus) inferred from qPCR and histology
Authors: Giulietti Lucilla , Nedberg Heidi Johansen , Karlsbakk Egil , Marathe Nachiket P. , Storesund Julia E. , Mæhle Stig , Fiksdal Ingrid Uglenes , Ghebretnsae Dawit Berhe , Levsen Arne 
Published: June 2022

Abstract
Kudoa thyrsites is a myxosporean parasite (Cnidaria, Myxozoa) that infects the skeletal and cardiac muscle of Northeast Atlantic (NEA) mackerel (Scomber scombrus). Heavy infections are associated with post-mortem myoliquefaction of the host skeletal muscle which reduces the quality of the fish product. The biological infection characteristics of the parasite in NEA mackerel are poorly known. This study examined the distribution of K. thyrsites in various organs of NEA mackerel from the northern North Sea, and elucidates the relationship between density of infection, developmental stage and parasite distribution in the musculature, and the extent of visible flesh myoliquefaction. Quantitative polymerase chain reaction (qPCR) data showed that K. thyrsites is unevenly distributed in the somatic musculature of the fish host, with highest density in the anterior ventral muscle sections—the belly flaps. A weak positive correlation was observed between the level of myoliquefaction and the parasite density in the fish host muscle. This relationship was also reflected by the amount and distribution of parasite developmental stages seen during histological examinations. Histological findings indicate an association between the dispersion of free myxospores and the level of myoliquefaction of the fish host muscle. Visceral organs were also found infected using qPCR, although at lower densities compared to the musculature.
Effect of Postoperative Oral Intake Status on Sarcopenia Six Months After Esophageal Cancer Surgery
Authors: Hijikata Nanako , Ishikawa Aiko , Matsuda Satoru , Kawakami Michiyuki , Muraoka Kaori , Ando Makiko , Mayanagi Shuhei , Irino Tomoyuki , Kawakubo Hirofumi , Kitagawa Yuko , Tsuji Tetsuya 
Published: June 2022

Abstract
Purpose
In patients with esophageal cancer, skeletal muscle mass has been reported to decrease progressively after surgery and be independently associated with a poor prognosis. The purpose of this study was to investigate perioperative changes in dysphagia, oral intake status, and nutritional status and identify factors related to sarcopenia 6 months after esophagectomy.

Methods
A total of 134 patients who underwent radical resection for thoracic esophageal cancer between March 2016 and July 2019 were analyzed retrospectively. The diagnosis of sarcopenia was made by CT taken 6 months postoperatively using the cut-off criteria of skeletal muscle index (SMI) < 52.4 cm2/m2 for male and SMI < 38.5 cm2/m2 for female patients. As factors related to postoperative sarcopenia, dysphagia, oral intake status, nutritional status, and physical function were extracted from the medical records. Multivariate logistic regression analysis was performed to identify perioperative risk factors related to sarcopenia 6 months after surgery.

Results
Of the 134 patients, 34.3% were judged to be unable to start oral intake on swallowing assessment. At discharge, 30.6% received tube feeding with or without oral intake. In the non-oral intake group on swallowing assessment, a significantly higher proportion of patients received tube feeding at discharge (p = 0.014). Preoperative BMI, postoperative handgrip strength, and tube feeding at discharge were independent risk factors for sarcopenia 6 months after esophagectomy in male patients.

Conclusion
Tube feeding at discharge is significantly related to postoperative sarcopenia in patients with esophageal cancer. Identifying high-risk groups might allow early detection of malnutrition and provision of appropriate care.
MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer
Authors: Jones Jac A. , Chavarri-Guerra Yanin , Corrêa Luisa Barreto Costa , Dean David R. , Epstein Joel B. , Fregnani Eduardo R. , Lee Jiyeon , Matsuda Yuhei , Mercadante Valeria , Monsen Ragnhild Elisabeth , Rajimakers Natasja J. H. , Saunders Deborah , Soto-Perez-de-Celis Enrique , Sousa Mariana S. , Tonkaboni Arghavan , Vissink Arjan , Yeoh Keng Soon , Davies Andrew N. 
Published: June 2022

Abstract

Purpose
The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the management of common oral problems in patients with advanced cancer.

Methods
This guidance was developed in accordance with the MASCC Guidelines Policy. A search strategy for Medline was developed, and the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials were explored for relevant reviews and trials, respectively. Guidance was categorised by the level of evidence, and “category of guideline” (i.e., “recommendation”, “suggestion” or “no guideline possible”).

Results
Twelve generic suggestions (level of evidence – 5), three problem-specific recommendations and 14 problem-specific suggestions were generated. The generic suggestions relate to oral hygiene measures, assessment of problems, principles of management, re-assessment of problems and the role of dental/oral medicine professionals.

Conclusions
This guidance provides a framework for the management of common oral problems in patients with advanced cancer, although every patient requires individualised management.
Semantic enhanced Top-k similarity search on weighted HIN
Authors: Zhang Yun , Yu Minghe , Zhang Tiancheng , Yu Ge 
Published: June 2022

AbstractSimilarity searches on heterogeneous information networks (HINs) have attracted wide attention from both industrial and academic areas in recent years; for example, they have been used for friend detection in social networks and collaborator recommendation in coauthor networks. The structural information on the HIN can be captured by multiple metapaths, and people usually utilize metapaths to design methods for similarity search. The rich semantics in HINs are not only structural information but also content stored in nodes. However, the content similarity of nodes was usually not valued in the existing methods. Although some researchers have recently considered both types of information in machine learning-based methods for similarity search, they have used structure and content information separately. To address this issue by balancing the influence of structure and content information flexibly in the process of searching, we propose a double channel convolutional neural network model for top-k similarity search, which uses path instances as model inputs and generates structure and content embeddings for nodes based on different metapaths. We design an attention mechanism to enhance the differences in metapaths for each node. Another attention mechanism is used to combine the content and structure information of nodes. Finally, an importance evaluation function is designed to improve the accuracy and make the model more explainable. The experimental results show that our search algorithm can effectively support top-k similarity search in HINs and achieve higher performance than existing approaches.
Adam or Eve? Automatic users’ gender classification via gestures analysis on touch devices
Authors: Guarino Alfonso , Lettieri Nicola , Malandrino Delfina , Zaccagnino Rocco , Capo Carmine 
Published: June 2022

AbstractGender classification of mobile devices’ users has drawn a great deal of attention for its applications in healthcare, smart spaces, biometric-based access control systems and customization of user interface (UI). Previous works have shown that authentication systems can be more effective when considering soft biometric traits such as the gender, while others highlighted the significance of this trait for enhancing UIs. This paper presents a novel machine learning-based approach to gender classification leveraging the only touch gestures information derived from smartphones’ APIs. To identify the most useful gesture and combination thereof for gender classification, we have considered two strategies:single-viewlearning, analyzing, one at a time, datasets relating to a single type of gesture, andmulti-viewlearning, analyzing together datasets describing different types of gestures. This is one of the first works to apply such a strategy for gender recognition via gestures analysis on mobile devices. The methods have been evaluated on a large dataset of gestures collected through a mobile application, which includes not only scrolls, swipes, and taps but also pinch-to-zooms and drag-and-drops which are mostly overlooked in the literature. Conversely to the previous literature, we have also provided experiments of the solution in different scenarios, thus proposing a more comprehensive evaluation. The experimental results show thatscroll downis the most useful gesture andrandom forestis the most convenient classifier for gender classification. Based on the (combination of) gestures taken into account, we have obtained F1-score up to 0.89 in validation and 0.85 in testing phase. Furthermore, the multi-view approach is recommended when dealing with unknown devices and combinations of gestures can be effectively adopted, building on the requirements of the system our solution is built-into. Solutions proposed turn out to be both an opportunity for gender-aware technologies and a potential risk deriving from unwanted gender classification.
Prognostic significance of additional histologic features for subclassification of pathological T3 colon cancer
Authors: Macchi Lorenzo , Bao Quoc Riccardo , Albertoni Laura , Fassan Matteo , Chiminazzo Valentina , Scarpa Marco , Spolverato Gaya , Pucciarelli Salvatore 
Published: June 2022

Abstract
Background
Additional histologic features of T3 colon cancer, such as tumour depth invasion beyond muscularis propria and elastic lamina invasion (ELI), have taken interest for a more accurate staging.

Methods
Patients with pT3 and pT4a (control group) colon adenocarcinoma were retrospectively collected from our institutional database. The study group was divided according to depth of tumour invasion < 5 mm and ≥ 5 mm, and into ELI − and ELI + . Chi-square test was used to compare the clinicopathological characteristics. OS and DFS were estimated using Kaplan–Meier method and compared with the log-rank test. Univariable and multivariable Cox proportional hazard models were employed to assess the effect on OS and DFS.

Results
Out of 290 pT3 tumours, 168 (58%) had a depth of tumour invasion < 5 mm and 122 (42%) ≥ 5 mm. The 5-year OS and DFS were 85.2, 68.7 and 60.9%, and 81.4, 73.9 and 60.1% in pT3 < 5 mm, pT3 ≥ 5 mm, and pT4a respectively (p = 0.001, p = 0.072). Considering ELI − (n = 157, 54%) and ELI + (n = 133, 46%), the 5-year OS and DFS were 78.9, 76.7, and 60.9%, and 75.5, 81.5, and 60.1% in ELI  − , ELI + and pT4a respectively (p = 0.955, p = 0.462). At multivariable analysis, the depth of invasion was found to be an independent predictive factor for OS (HR 2.04, 95%CI 1.28–3.24, p = 0.003) and DFS (HR 1.98, 95%CI 1.24–3.18, p = 0.004), while ELI did not result a prognostic factor for OS nor DFS.

Conclusion
In pT3 colon cancer, depth of tumour invasion ≥ 5 mm is an independent risk factor for OS and DFS, whereas ELI did not result a prognostic factor affecting OS nor DFS.
A systematic review of the cost-effectiveness of renal replacement therapies, and consequences for decision-making in the end-stage renal disease treatment pathway
Authors: Busink Ellen , Kendzia Dana , Kircelli Fatih , Boeger Sophie , Petrovic Jovana , Smethurst Helen , Mitchell Stephen , Apel Christian 
Published: June 2022

Abstract
Objectives
Comparative economic assessments of renal replacement therapies (RRT) are common and often used to inform national policy in the management of end-stage renal disease (ESRD). This study aimed to assess existing cost-effectiveness analyses of dialysis modalities and consider whether the methods applied and results obtained reflect the complexities of the real-world treatment pathway experienced by ESRD patients.

Methods
A systematic literature review (SLR) was conducted to identify cost-effectiveness studies of dialysis modalities from 2005 onward by searching Embase, MEDLINE, EBM reviews, and EconLit. Economic evaluations were included if they compared distinct dialysis modalities (e.g. in-centre haemodialysis [ICHD], home haemodialysis [HHD] and peritoneal dialysis [PD]).

Results
In total, 19 cost-effectiveness studies were identified. There was considerable heterogeneity in perspectives, time horizon, discounting, utility values, sources of clinical and economic data, and extent of clinical and economic elements included. The vast majority of studies included an incident dialysis patient population. All studies concluded that home dialysis treatment options were cost-effective interventions.

Conclusions
Despite similar findings across studies, there are a number of uncertainties about which dialysis modalities represent the most cost-effective options for patients at different points in the care pathway. Most studies included an incident patient cohort; however, in clinical practice, patients may switch between different treatment modalities over time according to their clinical need and personal circumstances.
Promoting health policies through financial incentives in renal care should reflect the cost-effectiveness of a comprehensive approach that considers different RRTs along the patient pathway; however, no such evidence is currently available.
Impact of a diabetes disease management program on guideline-adherent care, hospitalization risk and health care costs: a propensity score matching study using real-world data
Authors: Höglinger Marc , Wirth Brigitte , Carlander Maria , Caviglia Cornelia , Frei Christian , Rhomberg Birgitta , Rohrbasser Adrian , Trottmann Maria , Eichler Klaus 
Published: June 2022

Abstract
Objective
To evaluate the impact of a DMP for patients with diabetes mellitus in a Swiss primary care setting.

Methods
In a prospective observational study, we compared diabetes patients in a DMP (intervention group; N = 538) with diabetes patients receiving usual care (control group; N = 5050) using propensity score matching with entropy balancing. Using a difference-in-difference (DiD) approach, we compared changes in outcomes from baseline (2017) to 1-year (2017/18) and to 2-year follow-up (2017/19). Outcomes included four measures for guideline-adherent diabetes care, hospitalization risk, and health care costs.

Results
We identified a positive impact of the DMP on the share of patients fulfilling all measures for guideline-adherent care [DiD 2017/18: 7.2 percentage-points, p < 0.01; 2017/19: 8.4 percentage-points, p < 0.001]. The hospitalization risk was lower in the intervention group in both years, but only statistically significant in the 1-year follow-up [DiD 2017/18: – 5.7 percentage-points, p < 0.05; 2017/19: – 3.9 percentage points, n.s.]. The increase in health care costs was smaller in the intervention than in the control group [DiD 2017/18: CHF – 852; 2017/19: CHF – 909], but this effect was not statistically significant.

Conclusion
The DMP under evaluation seems to exert a positive impact on the quality of diabetes care, reflected in the increase in the measures for guideline-adherent care and in a reduction of the hospitalization risk in the intervention group. It also might reduce health care costs, but only a longer follow-up will show whether the observed effect persists over time.
On the microstructurally driven heterogeneous response of brain white matter to drug infusion pressure
Authors: Yuan Tian , Zhan Wenbo , Jamal Asad , Dini Daniele 
Published: June 2022

AbstractDelivering therapeutic agents into the brain via convection-enhanced delivery (CED), a mechanically controlled infusion method, provides an efficient approach to bypass the blood–brain barrier and deliver drugs directly to the targeted focus in the brain. Mathematical methods based on Darcy’s law have been widely adopted to predict drug distribution in the brain to improve the accuracy and reduce the side effects of this technique. However, most of the current studies assume that the hydraulic permeability and porosity of brain tissue are homogeneous and constant during the infusion process, which is less accurate due to the deformability of the axonal structures and the extracellular matrix in brain white matter. To solve this problem, a multiscale model was established in this study, which takes into account the pressure-driven deformation of brain microstructure to quantify the change of local permeability and porosity. The simulation results were corroborated using experiments measuring hydraulic permeability in ovine brain samples. Results show that both hydraulic pressure and drug concentration in the brain would be significantly underestimated by classical Darcy’s law, thus highlighting the great importance of the present multiscale model in providing a better understanding of how drugs transport inside the brain and how brain tissue responds to the infusion pressure. This new method can assist the development of both new drugs for brain diseases and preoperative evaluation techniques for CED surgery, thus helping to improve the efficiency and precision of treatments for brain diseases.