bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Honey Packaged Against The Testeless Taste of Salmonella typhi Bacteria
Authors: Darwin Bastian , Marlina Melli 
Published: January 2022

Demam tifoid atau typhus abdominalis adalah suatu infeksi akut yang terjadi pada usus halus disebabkan oleh bakteri gram negatif Salmonella typhi yang ditransmisikan melalui makanan maupun minuman yang terkontaminasi oleh feses atau urin dari orang terinfeksi. Madu kemasan adalah madu yang dibuat dari madu murni pilihan yang sebelumnya telah diproses sedemikian rupa secara steril dan higienis kemudian dikemas dengan berbagai ukuran dan harga yang lebih terjangkau dari pada madu alami. Penelitian ini bertujuan untuk mengetahui efektivitas madu kemasan terhadap daya hambat bakteri Salmonella typhi. Jenis penelitian ini dilakukan dalam bentuk eksperimen murni yang dianalisa secara diskriptif kuantitatif dan disajikan dalam bentuk diagram sederhana. Penelitian dilakukan di Laboratorium Mikrobiologi Institut Ilmu Kesehatan dan Teknologi Muhammadiyah Palembang dengan menggunakan metode disk difusi cakram kertas. Hasil penelitian ini didapatkan rata – rata efektivitas madu kemasan terhadap daya hambat bakteri Salmonella typhi pada konsentrasi 25% tidak terbentuk, 50% sebesar 2,4 mm dan 75% sebesar 5,4 mm dengan uji wilcoxon didapatkan nilai p = 0,006. Kesimpulan dari penelitian ini yaitu madu kemasan dengan konsentrasi 25%, 50%, dan 75% tidak memiliki efektivitas terhadap daya hambat bakteri Salmonella typhi.
Hubungan Titer Widal Dengan Jumlah Limfosit Dan Trombosit Pada Pasien Demam Typhoid Di Puskesmas Gunungsari Lombok Barat
Authors: Fitriyani Fitriyani , Pauzi Iswari , Jiwantoro Yudha Anggit 
Published: January 2022

Demam typhoid merupakan infeksi bakteri yang disebabkan oleh Salmonella typhi. Infeksi Salmonella typhi bersifat bakterimia yang masuk ke dalam usus halus kemudian menyebar ke sumsum tulang. Diagnosis Samonella typhi menggunakan uji widal dan pemeriksaan darah rutin. Uji Widal dan pemeriksaan darah rutin untuk melihat mekanisme tubuh terhadap limfosit dan trombosit yang diproduksi di sumsum tulang dan berfungsi sebagai pertahanan tubuh terhadap adanya infeksi. Bila bakteri ini sampai ke sumsum tulang maka akan menghambat pembentukan limfosit dan trombosit. Hal ini juga disebabkan adanya endotoksin dari bakteri sehingga pada kasus demam typhoid terjadinya limfositosis dan trombositopenia. Tujuan penelitian: Mengetahui hubungan titer widal dengan jumlah limfosit dan trombosit pada pasien demam typhoid. Metode penelitian: Observasional Analitik. Jumlah sampel yang digunakan sebanyak 24 sampel dengan menggunakan data primer. Data yang dikumpulkan berupa titer widal dengan jumlah limfosit dan trombosit. Kemudian diolah menggunakan uji statistik Korelasi Person. Hasil Penelitian: Rerata limfosit pada antigen O dengan titer 1/160 adalah 24,84%, titer 1/320 adalah 43,95%, rerata trombosit dengan titer 1/160 adalah 312.000 µL dan titer 1/320 adalah 230.750 µL. Sedangkan pada antigen H rerata jumlah limfosit dengan titer 1/160 adalah 35,48% dan titer 1/320 adalah 39,86%. Rerata jumlah trombosit dengan titer 1/160 adalah 196.670 µL dan titer 1/320 adalah 158.000 µL. Hasil uji statistik p>0,05. Kesimpulan: Tidak terdapat hubungan titer widal dengan jumlah limfosit dan trombosit pada pasien demam typhoid di Puskesmas Gunungsari Lombok Barat.
Inkorporasi Tepung Garut Dan Buah Pisang Kepok Pada Pembuatan Biskuit Dengan Klaim Tinggi Serat Serta Tinjauan Nilai Cerna Pati In Vitro Dan Gula Total
Authors: Choiriyah Nurul Azizah 
Published: January 2022

Objectives : The purpose of this study was to evaluate biscuit formulations from arrowroot flour and kepok banana for making high dietary biscuits according to BPOM regulation about high dietary fiber claim, also to study about starch digestibility and total sugar content of the biscuits. Methods : Variables of this study was F1 (the ratio of arrowroot flour : kepok banana = 50:125 g), F2 (the ratio of arrowroot flour : kepok banana = 75:100 g) and F3 (the ratio of arrowroot flour : kepok banana = 100:75 g). Results : The results of this study were the F3 biscuits have the highest dietary fiber (15 %). All biscuits fulfill the high dietary fiber claim according to BPOM regulations. Invitro starch digestibilitiy of F1, F2 and F3 biscuits were 35,07 %, 33,15 % and 34,80 %, respectively. Total sugar content of F1, F2 and F3 biscuits were 34,27 %, 32,45 % and 26,85 %, respectively. F3 biscuits have the lowest total sugar content.
GAMBARAN SISA MAKANAN PASIEN DI RSUD PETALA BUMI PROVINSI RIAU
Authors: Lestari Putri , Marlina Yessi 
Published: January 2022

Background : The high amount of leftover food is a serious problem that must be addressed immediately because the food served in the hospital has taken into account the quantity and quality according to the patient's needs. This also indicates that nutrition services are not achieved. The purpose of this study was to describe the leftover in Petala Bumi Hospital, Riau Province by classifying based on meal time, treatment class, food texture and type of diet. Research Methods : The study used cross sectional design. The population of this study were all patients in room 1 stclass, 2nd class and 3rd class with a total sample of 8 people using purposive sampling method. The leftover was measured using a 6-point Comstock scale for 3 days including breakfast, lunch, dinner, morning and evening snacks. Research Result : The results showed that leftover was mostly found in animal side dishes of the lunch menu (87,5%), blenderized food in first class (100%0, and low-salt and high-fiber diets (100%). Conclusion : The most leftovers are in blenderized foods and low-salt and high-fiber diets.
PENGARUH PENYULUHAN MAKANAN BERGIZI DENGAN METODE ULAR TANGGA TERHADAP PENINGKATAN PENGETAHUAN ANAK-ANAK
Authors: Hidayah Nurul , Jauhari M. Thonthowi , Al fariki M. Zulfikar 
Published: January 2022

Background : Health issues in Indonesia are still on the top topic. One of them is malnutrition and obesity which cause Indonesia encounters “double burden of malnutrition”. Sharing knowledge to children is a good starting point to fix the issue. This can increase children’s knowledge and brings Indonesia to escalate the quality of human resources in the future. Objective : The purpose of this research is to know the effectivity of socialization hold by ladder game method to the elevation of children’s knowledge into nutritious foods. Method : This has been done by three main steps; pre-test session, intervention, and post-test session. During pre-test and post-test, students were given several questions then the answers were analyzed using SPSS. Results : The results were analyzed statistically to highlight the description results which depicted that there is an influence of ladder game method during socialization to the increase of children’s knowledge. After giving a post-test, it showed a better result compared to pre-test. During pretest mean was 11.9 while at the post-test it reached approximately 15. Conclusion : It can be said that after the intervention by the ladder game method, the children’s insight is much more increasing even though it had no significancy
РОЛЬ ЄВРЕЙСЬКОЇ ВЛАСНОСТІ В ДИНАМІЦІ ГОЛОКОСТУ В ГЕНЕРАЛЬНІЙ ОКРУЗІ «ВОЛИНЬ-ПОДІЛЛЯ»: ФОКУС МІСЦЕВОГО НЕЄВРЕЙСЬКОГО НАСЕЛЕННЯ
Authors: Mykhalchuk Roman 
Published: January 2022

Процес привласнення єврейського майна неєврейським жителями під час Голокосту викликає значний інтерес у науковій літературі. Однак в академічних дослідженнях менше уваги приділяється ролі місцевого населення порівняно з такими ж злочинами, які чинила офіційна нацистська адміністрація. Насправді роль багатьох неєврейських жителів не можна розглядати як просто «спостерігачів» (bystanders), оскільки їхні дії впливали на динаміку Голокосту на місцевому рівні.
Перспектива заволодіти власністю жертв (економічний компонент геноциду) створювала своєрідне мотиваційне тло для співпраці цивільного населення з нацистами, коли обидві сторони усвідомлювали важливість взаємодії, заснованої на прагматичному меркантилізмі. Економічний фактор, мотивація місцевих жителів та антисемітська складова могли відігравати важливу роль у процесі здійснення Голокосту. Жага наживи мобілізувала найгірші людські інстинкти та впливала на людей різного походження, статі та віку, хоча вони мали досвід тісних довоєнних соціальних відносин та контактів із жертвами.
Результати цього дослідження вказують на набагато більшу роль цивільних осіб, місцевого неєврейського населення у привласненні майна жертв Голокосту, ніж це вважалося раніше та описувалося в академічній літературі. Хоча в статті розглядається питання привласнення єврейського майна на прикладі генерального округу «Волинь-Поділля» райхскомісаріату Україна, проте результати дослідження є важливими для загального розуміння подій Голокосту в Україні та в окупованих східних теренах нацистами під час Другої світової війни.
Peran Digital Marketing Terhadap Minat Berkunjung Wisatawan dalam Meningkatkan Pertumbuhan Ekonomi Kabupaten Garut : Store Atmosfer Variabel Moderating
Authors: Hanifah Hani Siti 
Published: January 2022

Pemulihan ekonomi nasional dan pertumbuhan ekonomi pasca pandemi Covid-19 dengan mengembangkan sektor prioritas seperti pada sektor pariwisata. Potensi daya tarik wisata yang dimiliki kota Garut, antara lain berupa keanekaragaman hayati, keunikan dan keaslian budaya daerah, keindahan bentang alam dan peninggalan sejarah sebagai salah satu bidikan penerimaan daerah yang berkontribusi pada kesejahteraan masyarakat. Tujuan penelitian untuk mengetahui peran digital marketing terhadap minat berkunjung wisatawan dalam meningkatkan pertumbuhan ekonomi kabupaten garut dan store atmosphere sebagai variabel moderating. Penelitian ini dengan menggunakan metode studi kasus mensyaratkan sumber data yang multi sources. Hasil penelitian menunjukkan bahwa upaya mendorong laju sektor pariwisata salah satunya dengan digital marketing dan tetap memperhatikan aspek store atmosphere sehingga dapat mendorong minat berkunjung wisatawan.
INSTRUMENTOS DE EVALUACIÓN FISIOTERAPÉUTICA EN POBLACIÓN NEONATAL:
Authors: Martínez Santa Jaime , Del Pilar Martínez Andrea , Avendaño Vanegas Janneth Milena , Melo Cuervo Alejandra , Alfonso Mantilla Jose Ivan 
Published: January 2022

RESUMEN
Introducción Los test y medidas utilizados en la evaluación específica de la población neonatal por el fisioterapeuta son diferentes a los usados en población pediátrica y adulta debido a que presentan un mayor costo fisiológico y una respuesta de estrés a la manipulación condicionando respuestas en el neonato. Por tal motivo, se hace de vital importancia profundizar e investigar en el conocimiento de los instrumentos de evaluación fisioterapéutica en el recién nacido de acuerdo a las categorías de la APTA con el fin de realizar procesos de evaluación específicos por categoría Método Revisión de la literatura por medio de la búsqueda de artículos científicos en bases de datos en el periodo 2000-2020 obteniendo 100 artículos Resultados El fisioterapeuta cuenta con instrumentos de evaluación en población neonatal para evaluar las siguientes categorías de la APTA: capacidad aeróbica y resistencia, características antropométricas, ventilación, respiración e intercambio gaseoso, circulación, funciones mentales, integridad de nervios craneales, desarrollo neuromotor, integridad refleja, rango de movimiento, desempeño muscular integridad integumentaria, dolor, tecnología de asistencia y factores ambientales Conclusiones El presente artículo evidencia que el fisioterapeuta tiene a disposición test y medidas con adecuados niveles de validez y confiabilidad para lograr un acercamiento al estado funcional del neonato lo que permitirá realizar un diagnóstico y tratamiento basados en el razonamiento clínico y evidencia científica.
Un enfoque de redes neuronales para la alineación de prótesis transtibiales
Authors: Luengas-C. Lely A. , Wanumen Luis Felipe , Camargo Casallas Esperanza 
Published: January 2022

Introducción: La presencia de enfermedades o alteraciones musculo-esqueléticas, así como trauma por accidentes tienen como posible consecuencia amputaciones, en Colombia se adiciona como causa el conflicto armado, ya que ha generado un grupo poblacional con discapacidad debido a los artefactos explosivos no identificados, donde amputaciones en extremidades inferiores son altamente frecuentes. La prótesis se emplea para que el amputado pueda adaptarse a su condición y reincorporarse en las actividades cotidianas, su uso se da luego de la alineación de la prótesis. La alineación tiende a ser un proceso subjetivo, donde el conocimiento y la práctica son esenciales en el momento de realizarla, no se tienen sistemas que reconozcan el impacto de este proceso sobre variables biomecánicas del sujeto con amputación. Por ello se propuso realizar una red neuronal que muestre la incidencia de la variación angular del socket de la prótesis en rangos articulares, la disposición de peso corporal y el centro de presión.
Método: Se realizó un estudio descriptivo donde el socket de la prótesis de un amputado transtibial se colocó en siete posiciones angulares diferentes, en cada posición se midieron parámetros biomecánicos, con estos datos se programó una red neuronal de regresión generalizada (GRNN) para predecir datos biomecánicos a partir de la ubicación del socket y se generó una interfaz gráfica para visualizar los cambios de los parámetros.
Resultados: La red neuronal permitió predecir el comportamiento de los ángulos de cadera, rodilla y tobillo, la ubicación del centro de presión y el peso corporal soportado tanto en ipsilateral (amputado) como en contralateral (no amputado); y en la interfaz gráfica se pudo mostrar la afectación.
Conclusión: El uso de herramientas tecnológicas permite construir sistemas de apoyo al personal médico, en este caso al protesista, con el fin de hacer mejoras en el procedimiento de ajuste de la prótesis en los sujetos con amputación transtibial.
Enhancing Squalene Production in Saccharomyces cerevisiae by Metabolic Engineering and Random Mutagenesis
Authors: Xia Lu , Lv Yunbin , Liu Song , Yu Shiqin , Zeng Weizhu , Zhou Jingwen 
Published: January 2022

Squalene is an important polyunsaturated triterpene with wide applications in the food, cosmetics, and pharmaceutical industries. Currently, the main method for squalene production is extraction from oil-producing plants, but the scale is limited. The microbial fermentation with Saccharomyces cerevisiae still needs improvement to be economically viable. This study aimed to improve squalene production by metabolic engineering and random mutagenesis. First, the mevalonate (MVA) pathway was enhanced, by integrating tHMG1 and IDI1 into multi-copy site Ty2. Subsequently, the ACL gene from Yarrowia lipolytica, encoding citrate lyase was introduced and the β-oxidation pathway was enhanced with multiple copies of key genes. In addition, a high throughput screening strategy based on Nile red staining was established for high squalene-producer screening. After treatment with ARTP mutagenesis, a higher-producing mutant was obtained, with squalene production enhanced by 18.4%. A two-stage fermentation of this mutant in a 5 L bioreactor produced 8.2 g/L of squalene. These findings may facilitate the development of industrial squalene production by fermentation and potentially, other terpenoids.
New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights
Authors: Malik M. Shaheer , Alsantali Reem I. , Jamal Qazi Mohammad Sajid , Seddigi Zaki S. , Morad Moataz , Alsharif Meshari A. , Hussein Essam M. , Jassas Rabab S. , Al-Rooqi Munirah M. , Abduljaleel Zainularifeen , Babalgith Ahmed O. , Altass Hatem M. , Moussa Ziad , Ahmed Saleh A. 
Published: January 2022

An efficient atom-economical synthetic protocol to access new imidazole-based N-phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized to provide a series of N-phenylbenzamide derivatives in a short reaction time (2–4 h) with an 80–85% yield. The cytotoxic evaluation revealed that derivatives 4e and 4f exhibited good activity, with IC50 values between 7.5 and 11.1 μM against the tested cancer cell lines. Computational studies revealed interesting insights: the docking of the active derivatives (4e and 4f) showed a higher affinity toward the target receptor protein than the control. Molecular dynamic simulations revealed that the active derivatives form stable complexes with the ABL1 kinase protein. Moreover, the ADME and drug-likeness of the derivatives reinforced the potential of the derivatives to be taken up for further development as anticancer agents.
Self-Reported Mobile Health-Based Risk Factor and CHA2DS2-VASc-Score Assessment in Patients With Atrial Fibrillation: TeleCheck-AF Results
Authors: Hermans Astrid N. L. , Gawałko Monika , Hillmann Henrike A. K. , Sohaib Afzal , van der Velden Rachel M. J. , Betz Konstanze , Verhaert Dominique , Scherr Daniel , Meier Julia , Sultan Arian , Steven Daniel , Terentieva Elena , Pisters Ron , Hemels Martin , Voorhout Leonard , Lodziński Piotr , Krzowski Bartosz , Gupta Dhiraj , Kozhuharov Nikola , Gruwez Henri , Vernooy Kevin , Pluymaekers Nikki A. H. A. , Hendriks Jeroen M. , Manninger Martin , Duncker David , Linz Dominik 
Published: January 2022

IntroductionThe TeleCheck-AF approach is an on-demand mobile health (mHealth) infrastructure incorporating mobile app-based heart rate and rhythm monitoring through teleconsultation. We evaluated feasibility and accuracy of self-reported mHealth-based AF risk factors and CHA2DS2-VASc-score in atrial fibrillation (AF) patients managed within this approach.Materials and MethodsConsecutive patients from eight international TeleCheck-AF centers were asked to complete an app-based 10-item questionnaire related to risk factors, associated conditions and CHA2DS2-VASc-score components. Patient's medical history was retrieved from electronic health records (EHR).ResultsAmong 994 patients, 954 (96%) patients (38% female, median age 65 years) completed the questionnaire and were included in this analysis. The accuracy of self-reported assessment was highest for pacemaker and anticoagulation treatment and lowest for heart failure and arrhythmias. Patients who knew that AF increases the stroke risk, more often had a 100% or ≥80% correlation between EHR- and app-based results compared to those who did not know (27 vs. 14% or 84 vs. 77%, P = 0.001). Thromboembolic events were more often reported in app (vs. EHR) in all countries, whereas higher self-reported hypertension and anticoagulant treatment were observed in Germany and heart failure in the Netherlands. If the app-based questionnaire alone was used for clinical decision-making on anticoagulation initiation, 26% of patients would have been undertreated and 6.1%—overtreated.ConclusionSelf-reported mHealth-based assessment of AF risk factors is feasible. It shows high accuracy of pacemaker and anticoagulation treatment, nevertheless, displays limited accuracy for some of the CHA2DS2-VASc-score components. Direct health care professional assessment of risk factors remains indispensable to ensure high quality clinical-decision making.
Interpretation of Convolutional Neural Networks for Acid Sulfate Soil Classification
Authors: Beucher Amélie , Rasmussen Christoffer B. , Moeslund Thomas B. , Greve Mogens H. 
Published: January 2022

Convolutional neural networks (CNNs) have been originally used for computer vision tasks, such as image classification. While several digital soil mapping studies have been assessing these deep learning algorithms for the prediction of soil properties, their potential for soil classification has not been explored yet. Moreover, the use of deep learning and neural networks in general has often raised concerns because of their presumed low interpretability (i.e., the black box pitfall). However, a recent and fast-developing sub-field of Artificial Intelligence (AI) called explainable AI (XAI) aims to clarify complex models such as CNNs in a systematic and interpretable manner. For example, it is possible to apply model-agnostic interpretation methods to extract interpretations from any machine learning model. In particular, SHAP (SHapley Additive exPlanations) is a method to explain individual predictions: SHAP values represent the contribution of a covariate to the final model predictions. The present study aimed at, first, evaluating the use of CNNs for the classification of potential acid sulfate soils located in the wetland areas of Jutland, Denmark (c. 6,500 km2), and second and most importantly, applying a model-agnostic interpretation method on the resulting CNN model. About 5,900 soil observations and 14 environmental covariates, including a digital elevation model and derived terrain attributes, were utilized as input data. The selected CNN model yielded slightly higher prediction accuracy than the random forest models which were using original or scaled covariates. These results can be explained by the use of a common variable selection method, namely recursive feature elimination, which was based on random forest and thus optimized the selection for this method. Notably, the SHAP method results enabled to clarify the CNN model predictions, in particular through the spatial interpretation of the most important covariates, which constitutes a crucial development for digital soil mapping.
Clinical Utility of Elecsys Anti-SARS-CoV-2 S Assay in COVID-19 Vaccination: An Exploratory Analysis of the mRNA-1273 Phase 1 Trial
Authors: Jochum Simon , Kirste Imke , Hortsch Sayuri , Grunert Veit Peter , Legault Holly , Eichenlaub Udo , Kashlan Basel , Pajon Rolando 
Published: January 2022

BackgroundThe ability to quantify an immune response after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential. This study assessed the clinical utility of the quantitative Roche Elecsys® Anti-SARS-CoV-2 S assay (ACOV2S) using samples from the 2019-nCoV vaccine (mRNA-1273) phase 1 trial (NCT04283461).MethodsSamples from 30 healthy participants, aged 18–55 years, who received two injections with mRNA-1273 at a dose of 25 μg (n=15) or 100 μg (n=15), were collected at Days 1 (first vaccination), 15, 29 (second vaccination), 43 and 57. ACOV2S results (shown in U/mL – equivalent to BAU/mL per the first WHO international standard) were compared with results from ELISAs specific to antibodies against the Spike protein (S-2P) and the receptor binding domain (RBD) as well as neutralization tests including nanoluciferase (nLUC80), live-virus (PRNT80), and a pseudovirus neutralizing antibody assay (PsVNA50).ResultsRBD-specific antibodies were already detectable by ACOV2S at the first time point of assessment (d15 after first vaccination), with seroconversion before in all but two participants (25 μg dose group); all had seroconverted by Day 29. Across all post-baseline visits, geometric mean concentration of antibody levels was 3.27–7.48-fold higher in the 100 μg compared with the 25 μg dose group. ACOV2S measurements were highly correlated with those from RBD ELISA (Pearson’s r=0.938; p&lt;0.0001) and S-2P ELISA (r=0.918; p&lt;0.0001). For both ELISAs, heterogeneous baseline results and smaller increases in antibody levels following the second vs first vaccination compared with ACOV2S were observed. ACOV2S showed absence of any baseline noise indicating high specificity detecting vaccine-induced antibody response. Moderate–strong correlations were observed between ACOV2S and neutralization tests (nLUC80 r=0.933; PsVNA50, r=0.771; PRNT80, r=0.672; all p ≤ 0.0001).ConclusionThe Elecsys Anti-SARS-CoV-2 S assay (ACOV2S) can be regarded as a highly valuable method to assess and quantify the presence of RBD-directed antibodies against SARS-CoV-2 following vaccination and may indicate the presence of neutralizing antibodies. As a fully automated and standardized method, ACOV2S could qualify as the method of choice for consistent quantification of vaccine-induced humoral response.