bluuebunny/crossref_metadata_2025_split huggingface dataset:
SELF-EDUCATION OF THE EDUCATOR IN A MODERN PRESCHOOL EDUCATION INSTITUTION
Authors: Kryvda Valentyna 
Published: August 2022

The article actualizes the issue of educator’s self-education in a modern preschool institution. It is noted that in the conditions of reforming and updating the system of preschool education one of the priority tasks is the formation of a creative personality of a specialist capable of self-development, self-education, and innovation. The study shows that Ukraine’s integration into the international European society is an update of the education system aimed at training educated, creative, and competitive professionals who are ready to meet today’s new challenges and adopt and apply modern concepts, projects, innovative methods, and educational tools and able to constantly learn. The content of the concept of “self-education” as an integral ability, the result of improving professional competence, which is to master, review, and clarify information, disseminate self-education practices aimed at self-improvement and self-realization of interests and needs of educators of modern preschool education. It is proved that in the context of professional activity of a modern preschool educator self-education is determined by its qualitative personal characteristics, which includes a system of improving theoretical knowledge, pedagogical skills, mastering innovative technologies, forms and methods, teaching and educating preschool children, learning and implementing best practices, modern achievements of pedagogical and psychological science, organization of modern educational process in preschool education, ability, and readiness for continuous self-education in preschool, in order to ensure the effectiveness of this activity.
Keywords: self-education; self-educational activity; organization of self-education; preschool institution; self-analysis; self-preparation; self-education planning; innovative forms of self-educational activity.
“Our literature will speak about victory, life, death, loss, love, and peace”: A Conversation with Olga Derkachova
Authors: Kostecka Weronika , Mik Anna , Niewieczerzał Marta , Skowera Maciej , Stępień Karolina 
Published: August 2022

This conversation with Olga Derkachova explores Ukrainian children’s and young adult literature, especially in the context of the Russian invasion of Ukraine.
Contaminação por bactérias resistentes a antibióticos em alimentos: o perigo de comer vegetais prontos para o consumo
Authors: Nilo Maryah Christina dos Santos Senna , Marin Victor Augustus 
Published: August 2022

Introdução: A alta tendência ao consumo de vegetais prontos para o consumo nos últimos anos, tem sido significativamente associado a surtos de infecções e intoxicações alimentares. Esses alimentos são potencialmente contaminados por microorganismos patogênicos e a maior preocupação está relacionada com a exposição humana a agentes antimicrobianos resistentes, o que encorajou os pesquisadores a estudarem várias fontes de cepas resistentes em alimentos. Objetivo: o objetivo desse estudo foi elucidar a contaminação de vegetais prontos para o consumo com bactérias resistentes a antibióticos e os riscos de consumi-los. Metodologia: trata-se de uma revisão narrativa da literatura que buscou elucidar os riscos do consumo de vegetais prontos para o consumo devido a sua contaminação com bactérias resistentes a antibióticos. A pesquisa foi realizada através do acesso online nas bases de dados: Google Scholar, National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Biblioteca Virtual em Saúde (BVS). Resultados e Discussões: Resultados e Discussões: Em todos os 25 artigos pesquizados foram encontradas bactérias resistentes. No total obtivemos uma média de 86,51% de bactérias que foram resistentes a pelo menos 1 antibiótico. Das bactérias que demonstraram resistência 76,92 foram resistentes a pelo menos 5 antibióticos e 44,23% foram a mais de 10 antibióticos. Conclusão: O presente estudo demonstra que os vegetais prontos para o consumo possuem uma grande microbiota com diferentes gêneros de bactérias e essas com resistência aos antibióticos.
Pemanfaatan ekstrak Ethanol buah Senduduk (Melastoma malabathricum L.) diformulasikan sebagai pewarna pada sediaan Eye Shadow Cream
Authors: Diana Vivi Euis , Fadillah Eva , Rizky Putri 
Published: August 2022

Eye shadow adalah bagian dari kosmetika yang digunakan pada kelopak mata dan dibawah alis. Eye shadow merupakan salah satu jenis preparat dekoratif yang memerlukan bahan yang sangat aman dan cara pemakaian yang hati-hati karena dikenakan pada kulit dekat mata, biasanya pada kelopak mata atas Eye shadow dalam bentuk cream memiliki keuntungan mampu melekat pada permukaan tempat pemakaian dalam waktu yang cukup lama. Bentuk cream dapat memberikan efek mengkilap, berminyak, melembabkan dan mudah tersebar merata, mudah diusap dan mudah dicuci dengan air. Desain yang digunakan pada penelitian ini adalah desain penelitian eksperimental laboratorium, meliputi penyiapan sampel, pembuatan ekstrak, formulasi sediaan, pemeriksaan mutu fisik, uji iritasi terhadap sediaan, dan uji kesukaan dengan konsentrasi 7%, 9%, dan 11%. Hasil penelitian Zat warna dari ekstrak buah senduduk (Melastoma malabathricum L.) dapat diformulasikan ke dalam sediaan eye shadow sebagai pewarna alami dan memiliki susunan yang homogen, pH yang sesuai, sediaan yang stabil, daya oles, daya lekat, dan daya sebar yang baik, tidak mengiritasi, dan sangat disukai panelis. Perbedaan konsentrasi ekstrak buah senduduk (Melastoma malabathricum L.) yang diformulasikan dalam sediaan eye shadow cream memberikan pengaruh pada warna sediaan. Semakin tinggi konsentrasi ekstrak buah senduduk, maka semakin pekat pula pigmen warna pada sediaan. Kesimpulannya ekstrak buah senduduk dapat diformulasikan ke dalam sediaan eye shadow cream sebagai pewarna alami dan Semakin tinggi konsentrasi ekstrak buah senduduk, maka semakin pekat pula pigmen warna pada sediaan.
Pressure‐Induced Metallization of Lead‐Free Halide Double Perovskite (NH4)2PtI6
Authors: Wang Jiaxiang , Wang Lingrui , Li Yuqiang , Fu Ruijing , Feng Youjia , Chang Duanhua , Yuan Yifang , Gao Han , Jiang Sheng , Wang Fei , Guo Er‐jia , Cheng Jinguang , Wang Kai , Guo Haizhong , Zou Bo 
Published: August 2022

AbstractMetallization has recently garnered significant interest due to its ability to greatly facilitate chemical reactions and dramatically change the properties of materials. Materials displaying metallization under low pressure are highly desired for understanding their potential properties. In this work, the effects of the pressure on the structural and electronic properties of lead‐free halide double perovskite (NH4)2PtI6 are investigated systematically. Remarkably, an unprecedented bandgap narrowing down to the Shockley–Queisser limit is observed at a very low pressure of 0.12 GPa, showing great promise in optoelectronic applications. More interestingly, the metallization of (NH4)2PtI6 is initiated at 14.2 GPa, the lowest metallization pressure ever reported in halide perovskites, which is related to the continuous increase in the overlap between the valence and conduction band of I 5p orbital. Its structural evolution upon compression before the metallic transition is also tracked, from cubic Fm‐3m to tetragonal P4/mnc and then to monoclinic C2/c phase, which is mainly associated with the rotation and distortions within the [PtI6]2– octahedra. These findings represent a significant step toward revealing the structure–property relationships of (NH4)2PtI6, and also prove that high‐pressure technique is an efficient tool to design and realize superior optoelectronic materials.
Cavitary lung opacity of unusual cause during Behçet disease
Authors: Chebbi Donia , Damak Chifa , Frikha Faten , Abid Walid , Rebai Mohamed , Snoussi Mouna , Salah Raida Ben , Marzouk Sameh , Hentati Abdessalem , Bahloul Zouhir 
Published: August 2022

AbstractPulmonary artery aneurysm must be evoked in front of any hemoptysis in a patient with Behçet disease as it requires urgent immunosuppressive therapy and often surgery.
Probe lifetime around natural satellites with obliquity
Authors: Cinelli Marco , Lei Hanlun , Ortore Emiliano , Circi Christian 
Published: August 2022

AbstractThe dynamics of a probe orbiting a moon can be significantly influenced by the non-coincidence between the moon’s equatorial and orbital planes. Thus, we performed a general analysis about the effects of the angle (obliquity) between the above-mentioned planes and of the angle (nodal phasing) between the nodal lines of the mother planet’s apparent orbit and the probe orbit on the lifetime of the probe. The lifetime, strictly correlated to the variations in eccentricity of the probe orbit, was evaluated starting from low values of the semi-major axis, moderate eccentricity, and high inclination to offer high ground spatial resolution and extend latitudinal coverage of the natural satellite. This investigation, carried out through numerical simulations, may be useful for identifying the optimal initial conditions of the probe’s orbit elements, leading to an important increase in the probe lifetime in missions devoted to the exploration of natural satellites.
Implementation and outcomes of a clinician-directed intervention to improve antibiotic prescribing for acute respiratory tract infections within the Veterans’ Affairs Healthcare System
Authors: Madaras-Kelly Karl J. , Rovelsky Suzette A. , McKie Robert A. , Nevers McKenna R. , Ying Jian , Haaland Benjamin A. , Kay Chad L. , Christopher Melissa L. , Hicks Lauri A. , Samore Mathew H. 
Published: August 2022

AbstractObjective:To determine whether a clinician-directed acute respiratory tract infection (ARI) intervention was associated with improved antibiotic prescribing and patient outcomes across a large US healthcare system.Design:Multicenter retrospective quasi-experimental analysis of outpatient visits with a diagnosis of uncomplicated ARI over a 7-year period.Participants:Outpatients with ARI diagnoses: sinusitis, pharyngitis, bronchitis, and unspecified upper respiratory tract infection (URI-NOS). Outpatients with concurrent infection or select comorbid conditions were excluded.Intervention(s):Audit and feedback with peer comparison of antibiotic prescribing rates and academic detailing of clinicians with frequent ARI visits. Antimicrobial stewards and academic detailing personnel delivered the intervention; facility and clinician participation were voluntary.Measure(s):We calculated the probability to receive antibiotics for an ARI before and after implementation. Secondary outcomes included probability for a return clinic visits or infection-related hospitalization, before and after implementation. Intervention effects were assessed with logistic generalized estimating equation models. Facility participation was tracked, and results were stratified by quartile of facility intervention intensity.Results:We reviewed 1,003,509 and 323,023 uncomplicated ARI visits before and after the implementation of the intervention, respectively. The probability to receive antibiotics for ARI decreased after implementation (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.78–0.86). Facilities with the highest quartile of intervention intensity demonstrated larger reductions in antibiotic prescribing (OR, 0.69; 95% CI, 0.59–0.80) compared to nonparticipating facilities (OR, 0.89; 95% CI, 0.73–1.09). Return visits (OR, 1.00; 95% CI, 0.94–1.07) and infection-related hospitalizations (OR, 1.21; 95% CI, 0.92–1.59) were not different before and after implementation within facilities that performed intensive implementation.Conclusions:Implementation of a nationwide ARI management intervention (ie, audit and feedback with academic detailing) was associated with improved ARI management in an intervention intensity–dependent manner. No impact on ARI-related clinical outcomes was observed.
Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study
Authors: Gresko Shelley A. , Rieselbach Maya , Corley Robin P. , Reynolds Chandra A. , Rhee Soo Hyun 
Published: August 2022

AbstractThe present study examined putative environmental predictors of adolescent substance use, using a prospective adoption design to distinguish between environmental mediation (i.e., parenting influencing adolescent substance use), passive gene–environment correlation (i.e., parental genetic predisposition influencing the association between parenting characteristics and adolescent substance use), and evocative gene–environment correlation (i.e., children’s genetic predisposition influencing parenting). Longitudinal data from the Colorado Adoption Project (395 adoptees, 491 nonadoptees, 485 adoptive parents, and 490 biological parents) were examined. Children (48% girls) were assessed at ages 1 to 17 years. Over 90% of the sample were non-Hispanic White. Associations between parenting and adolescent substance use were compared between adoptive and nonadoptive families. Positive, negative, and inconsistent parenting measures in early childhood through adolescence were not consistently associated with adolescent substance use, with only 6% of correlations being statistically significant (r = −0.152 to .207). However, parent–child relationship quality assessed from childhood to adolescence and orientation to parents assessed during adolescence were significantly, negatively associated with adolescent substance use, with 71% of correlations being statistically significant (r = −0.88 to −0.11). There was little evidence of sex differences in the associations. Environmental mediation, rather than passive or evocative gene–environment correlation, explained most associations.
Brief Report: Mortality After Loss to Follow-Up—A Linkage Study of People Living With HIV in Thailand and Malaysia
Authors: Jiamsakul Awachana , Gani Yasmin , Avihingsanon Anchalee , Azwa Iskandar , Chaiwarith Romanee , Khusuwan Suwimon , Ross Jeremy , Law Matthew , Kiertiburanakul Sasisopin ,   on behalf of IeDEA Asia-Pacific
Published: August 2022

Background:
Linkage studies have reported high rates of previously unascertained mortality among people living with HIV (PLHIV) who have been lost to follow-up (LTFU). We assessed survival outcomes among PLHIV who were LTFU in Thailand and Malaysia, through linkages to a national death registry or HIV database.

Methods:
Data linkages with the national death registry or national HIV database were conducted in 2020 on all PLHIV who met LTFU criteria while enrolled in care at participating HIV clinical sites. LTFU was defined as having no documented clinical contact in the previous year, excluding transfers and deaths. Survival time was analyzed using the Cox regression, stratified by site.

Results:
Data linkages were performed for 489 PLHIV who had been LTFU at sites in Malaysia (n = 2) and Thailand (n = 4). There were 151 (31%) deaths after being LTFU; the mortality rate was 4.89 per 100 person-years. Risk factors for mortality after being LTFU were older age [41–50 years: hazard ratio (HR) = 1.99, 95% confidence interval (CI): 1.08 to 3.68; and older than 50 years: HR = 4.93, 95% CI: 2.63 to 9.22; vs. age 30 years or younger]; receiving NRTI + PI (HR = 1.87, 95% CI: 1.22 to 2.85 vs. NRTI + NNRTI); positive hepatitis C antibody (HR = 2.25, 95% CI: 1.40 to 3.62); and having previous AIDS illness (HR = 1.45, 95% CI: 1.03 to 2.05). An improved survival was seen with a higher CD4 count (CD4 351–500 cells/µL: HR = 0.40, 95%CI: 0.21–0.76; and CD4 >500 cells/µL: HR = 0.43, 95%CI: 0.25–0.75; vs. CD4 ≤200 cells/µL).

Conclusions:
Almost one-third of PLHIV who were LTFU in this cohort had died while out of care, emphasizing the importance of efforts to reengage PLHIV after they have been LTFU and ensure they have access to ongoing ART.
Oncogenic ERRB2 signals through the AP-1 transcription factor to control mesenchymal-like properties of oesophageal adenocarcinoma
Authors: Ogden Samuel , Ahmed Ibrahim , Fullwood Paul ,   the OCCAMS consortium, Francavilla Chiara , Sharrocks Andrew D. 
Published: August 2022

AbstractOesophageal adenocarcinoma (OAC) is a deadly disease with poor survival statistics and few targeted therapies available. One of the most common molecular aberrations in OAC is amplification or activation of the gene encoding the receptor tyrosine kinase ERBB2, and ERBB2 is targeted in the clinic for this subset of patients. However, the downstream consequences of these ERBB2 activating events are not well understood. Here we used a combination of phosphoproteomics, open chromatin profiling and transcriptome analysis on cell line models and patient-derived datasets to interrogate the molecular pathways operating downstream from ERBB2. Integrated analysis of these data sets converge on a model where dysregulated ERBB2 signalling is mediated at the transcriptional level by the transcription factor AP-1. AP-1 in turn controls cell behaviour by acting on cohorts of genes that regulate cell migration and adhesion, features often associated with EMT. Our study therefore provides a valuable resource for the cancer cell signalling community and reveals novel molecular determinants underlying the dysregulated behaviour of OAC cells.
Validation of Responsiveness of Physicians Scale (ROP-Scale) for hospitalised COVID-19 patients in Bangladesh
Authors: Joarder Taufique , Islam Mohammad Aminul , Islam Md Shariful , Mostari Shabnam , Hasan Md. Tanvir 
Published: August 2022

Abstract
Background
Responsiveness of Physicians (ROP) is defined as the social actions by physicians aimed at meeting the legitimate expectations of healthcare users. Even though patients’ expectations regarding ROP have increased during the COVID-19 pandemic, the psychometrically-validated ROP-Scale is difficult to apply in hospital settings. The goal of this study is to validate the existing ROP-Scale to measure the responsiveness of hospital physicians during the ongoing COVID-19 pandemic in Bangladesh.

Methods
We conducted a cross-sectional phone survey involving 213 COVID-19 hospital patients, randomly selected from the government database. We applied the Delphi method for content validity, exploratory and confirmatory factor analyses for construct validity, Cronbach’s alpha and corrected item-total correlation for internal consistency reliability, and Pearson’s correlation between the scale and overall patient satisfaction for concurrent validity.

Results
After removing survey items based on data sufficiency, collinearity, factor loading derived through exploratory factor analysis, and internal consistency, the final version of the COVID-19 ROP-Scale consisted of 7 items, grouped under Informativeness, Trustworthiness and Courteousness domains. The confirmatory factor analysis supported the three domains with acceptable model fit [Root mean squared error of approximation (RMSEA) = 0.028, Comparative fit index (CFI) = 0.997, Tucker-Lewis index (TLI) = 0.994)]. The corrected item-total correlation ranged between 0.45 and 0.71. Concurrent validity was ascertained by the high correlation (0.84) between patient satisfaction and the COVID-19 ROP-Scale. Based on the mean domain score, the highest- and the lowest-scoring responsiveness domains were ‘Trustworthiness’ (7.85) and ‘Informativeness’ (7.28), respectively, whereas the highest- and the lowest-scoring items were ‘Not being involved in illegal activities’ (7.97), and ‘Service-oriented, not business-like attitude’ (6.63), respectively.

Conclusions
The 7-item COVID-19 ROP-Scale was demonstrated to be feasible, valid, and internally consistent. Therefore, its application can help amend past mistakes in health service provision and improve care for the hospitalised COVID-19 patients or other patients suffering from similar conditions. This study can contribute to the national decision-making regarding hospital care, open up further avenues in the health policy and system research, and eventually improve the quality of care provided to Bangladeshi patients seeking hospital services. Moreover, findings yielded by this study can be incorporated into doctors’ medical education and in-service training.
Associations between fully-automated, 3D-based functional analysis of the left atrium and classification schemes in atrial fibrillation
Authors: Pradella Maurice , Anastasopoulos Constantin , Yang Shan , Moor Manuela , Badertscher Patrick , Gehweiler Julian E. , Spies Florian , Haaf Philip , Zellweger Michael , Sommer Gregor , Stieltjes Bram , Bremerich Jens , Osswald Stefan , Kühne Michael , Sticherling Christian , Knecht Sven 
Published: August 2022

Background
Atrial fibrillation (AF) has been linked to left atrial (LA) enlargement. Whereas most studies focused on 2D-based estimation of static LA volume (LAV), we used a fully-automatic convolutional neural network (CNN) for time-resolved (CINE) volumetry of the whole LA on cardiac MRI (cMRI). Aim was to investigate associations between functional parameters from fully-automated, 3D-based analysis of the LA and current classification schemes in AF.

Methods
We retrospectively analyzed consecutive AF patients who underwent cMRI on 1.5T systems including a stack of oblique-axial CINE series covering the whole LA. The LA was automatically segmented by a validated CNN. In the resulting volume-time curves, maximum, minimum and LAV before atrial contraction were automatically identified. Active, passive and total LA emptying fractions (LAEF) were calculated and compared to clinical classifications (AF Burden score (AFBS), increased stroke risk (CHA2DS2VASc≥2), AF type (paroxysmal/persistent), EHRA score, and AF risk factors). Moreover, multivariable linear regression models (mLRM) were used to identify associations with AF risk factors.

Results
Overall, 102 patients (age 61±9 years, 17% female) were analyzed. Active LAEF (LAEF_active) decreased significantly with an increase of AFBS (minimal: 44.0%, mild: 36.2%, moderate: 31.7%, severe: 20.8%, p<0.003) which was primarily caused by an increase of minimum LAV. Likewise, LAEF_active was lower in patients with increased stroke risk (30.7% vs. 38.9%, p = 0.002). AF type and EHRA score did not show significant differences between groups. In mLRM, a decrease of LAEF_active was associated with higher age (per year: -0.3%, p = 0.02), higher AFBS (per category: -4.2%, p<0.03) and heart failure (-12.1%, p<0.04).

Conclusions
Fully-automatic morphometry of the whole LA derived from cMRI showed significant relationships between LAEF_active with increased stroke risk and severity of AFBS. Furthermore, higher age, higher AFBS and presence of heart failure were independent predictors of reduced LAEF_active, indicating its potential usefulness as an imaging biomarker.