bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Time From Diagnosis to Treatment Start on the Outcomes of Patients With Nonmetastatic Anal Squamous Cell Carcinoma
Authors: Abdel-Rahman Omar , Ghosh Sunita 
Published: December 2022

Objective:
To assess the impact of time from diagnosis to treatment on the survival outcomes of patients with nonmetastatic anal squamous cell carcinoma, controlling for other clinicopathological features.

Methods:
Surveillance, Epidemiology, and End Results research plus database was accessed, and patients with nonmetastatic anal squamous cell carcinoma were reviewed. Factors associated with longer time to treatment were evaluated through multivariable logistic regression analysis. Kaplan-Meier survival estimates were used to examine survival differences according to time to treatment (≤2 vs. >2 mo), and multivariable Cox regression analysis was used to examine factors associated with worse overall and cancer-specific survival.

Results:
A total of 13,032 patients were considered eligible and they were included in this study. The following factors were associated with longer time to treatment (>2 mo): male sex (odds ratio [OR]: 1.503; 95% CI, 1.292 to 1.749), and non-White race (OR for Black vs. White patients: 1.846; 95% CI, 1.488 to 2.290; OR for American Indian vs. White patients: 2.414; 95% CI, 1.197 to 4.872; OR for Asian-Pacific Islanders vs. White patients: 2.182; 95% CI, 1.440 to 3.309). Using Kaplan-Meier survival estimates, longer time to treatment was associated with worse overall survival (median OS for >2 mo=109 mo; for ≤2 mo=164 mo P<0.0001). Using multivariable Cox regression analysis, the following factors were associated with worse overall survival: older age (hazard ratio [HR]: 1.037; 95% CI, 1.034 to 1.039), male sex (HR: 1.650; 95% CI, 1.548 to 1.758), Black race (HR: 1.341; 95% CI, 1.210 to 1.487), advanced stage (HR for regional vs. localized stage: 1.596; 95% CI, 1.500 to 1.698), and longer time to treatment (HR: 1.385; 95% CI, 1.222 to 1.571).

Conclusions:
Time from diagnosis to treatment longer than 2 months is associated with worse survival outcomes among patients with nonmetastatic anal squamous cell carcinoma.
Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values
Authors: Casiglia Edoardo , Tikhonoff Valérie , Virdis Agostino , Grassi Guido , Angeli Fabio , Barbagallo Carlo M. , Bombelli Michele , Cicero Arrigo F.G. , Cirillo Massimo , Cirillo Pietro , Dell’Oro Raffaella , D’elia Lanfranco , Desideri Giovambattista , Ferri Claudio , Galletti Ferruccio , Gesualdo Loreto , Giannattasio Cristina , Iaccarino Guido , Lippa Luciano , Mallamaci Francesca , Masi Stefano , Maloberti Alessandro , Masulli Maria , Mazza Alberto , Mengozzi Alessandro , Muiesan Maria Lorenza , Nazzaro Pietro , Palatini Paolo , Parati Gianfranco , Pontremoli Roberto , Quarti-Trevano Fosca , Rattazzi Marcello , Reboldi Gianpaolo , Rivasi Giulia , Salvetti Massimo , Tocci Giuliano , Ungar Andrea , Verdecchia Paolo , Viazzi Francesca , Volpe Massimo , Borghi Claudio 
Published: December 2022

Objective:
In the frame of the Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on a regional community basis from all the territory of Italy under the patronage of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension, we searched for the cut-off values of the ratio between serum uric acid (SUA) and serum creatinine (sCr) able to predict cardiovascular (CV) events.

Methods:
Among 20 724 participants followed-up for 126 ± 64 months, after detecting cut-off by the receiver operating characteristic curves, we calculated by Cox models adjusted for confounders having CV events as dependent variable the hazard ratio (HR) of SUA/sCr > cut-off. We also verified if the role of cut-off varied with increasing SUA/sCr.

Results:
A plausible prognostic cut-off of SUA/sCr was found and was the same in the whole database, in men and in women (>5.35). The HR of SUA/sCr > cut-off was 1.159 (95% confidence interval [CI] 1.092–1.131, P < 0.03) in all, 1.161 (95% CI 1.021–1.335, P < 0.02) in men, and 1.444 (95% CI 1.012–1.113, P < 0.03) in women. In increasing quintiles of SUA/sCr the cut-offs were >3.08, >4.87, >5.35, >6.22 and >7.58, respectively. The HRs significantly increased from the 3rd to the 5th quintile (1.21, 95% CI 1.032–1.467, P = 0.018; 1.294, 95% CI 1.101–1.521, P = 0.002; and 1.642, 95% CI 1.405–1.919, P < 0.0001; respectively), that is, over 5.35, whereas the 2nd quintile was not significantly different from the 1st (reference).

Conclusion:
Having SUA/sCr >5.35 is an independent CV risk indicator both in men and women. The cut-off is dynamic and significantly increases with increasing SUA/sCr.
Intense Pulse Light Combined With Low-Level Light Therapy in Dry Eye Disease: A Systematic Review
Authors: Ballesteros-Sánchez Antonio , Gargallo-Martínez Beatriz , Sánchez-González María Carmen , Sánchez-González José-María 
Published: December 2022

Objectives:
To evaluate the improvement in symptoms and signs associated with intense pulse light (IPL) combined with low-level light therapy (LLLT) in the treatment of dry eye disease (DED).

Methods:
A systematic review of full-length original studies reporting the effects of IPL combined with LLLT for DED in two databases, PubMed and Scopus, was performed according to the PRISMA statement. The quality assessment tool for case series studies from the National Heart, Lung, and Blood Institute was used to analyze the quality of the studies selected.

Results:
The search provided a total of 393 articles, of which six were included. Significant decreases in the Ocular Surface Disease Index (OSDI) score, meibomian gland dysfunction (MGD) score, MGD grade, and meiboscore and increases in tear film stability, lipid layer thickness, and loss area of the meibomian gland have been reported. Concerning tear volume, tear meniscus height, and Schirmer test remained unchanged. In relation to tear osmolarity and corneal fluorescein staining, contradictory outcomes were found.

Conclusions:
Intense pulse light combined with LLLT for the treatment of dry eye improves OSDI, tear film stability, and meibomian gland function; thus, this treatment may be recommended for DED patients due to MGD.
Tecovirimat Use in Ambulatory and Hospitalized Patients With Monkeypox Virus Infection
Authors: Wu En-Ling , Osborn Rebecca L. , Bertram Christie M. , Moore W. Justin , Galvin Shannon R. , Bolon Maureen K. , Masters Mary Clare , Krueger Karen M. 
Published: December 2022

Abstract
In this case series of 20 ambulatory and hospitalized adult patients treated for monkeypox virus at a large academic medical center in Chicago, Illinois, tecovirimat use was reserved for those with or at high risk of severe disease, delayed because of logistical and clinical factors, but well tolerated.
Assessing Changes in Insurance Status and Access to Care Among Patients Attending Chicago Sexually Transmitted Infection Specialty Clinics From 2013 to 2019
Authors: Korban Colin , Tabidze Irina , Broussard Dawn , Cruz Yvonne , Kern David , Mehta Supriya D. 
Published: December 2022

Background
Public sexually transmitted infection (STI) clinics are safety net providers for uninsured and underinsured individuals but are at risk for closure due to declining budgets and shifting priorities. This study sought to assess changes in insurance status and access to preventive care among public STI clinic patients after immediate and long-term implementation of the Affordable Care Act (ACA).

Methods
Patients receiving care in STI clinics administered by Chicago Department of Public Health were asked to complete an anonymous survey in 2013, 2014, and 2019. We estimated the prevalence rate ratio (PRR) of (1) being insured and (2) having access to preventive care over time, adjusted for age, race, and gender/sexual orientation, and employment status.

Results
Among 1711 respondents, compared with 2013 patients, patients were 1.41 (adjusted PRR [aPRR]) times more likely to report being insured in 2014 (95% confidence interval, 1.11–1.77) and 1.24 (aPRR) times more likely to report being insured in 2019 (95% confidence interval, 0.99–1.55). After adjusting for other significant variables (age, sex and orientation, and insurance status), reported access to preventive care increased by 34% among respondents in 2019 as compared with 2013 (aPRR, 1.34). Unsurprisingly, being insured was associated with increased preventive care access (aPRR, 1.78).

Conclusions
Even after the implementation of the Affordable Care Act, a survey of public STI clinic patients in Chicago found a sizeable proportion of individuals without insurance, and many lacked access to preventive care, highlighting the continued need for these safety net clinics to provide STI care.
Environmental exposures are important risk factors for advanced liver fibrosis in African American adults: NHANES 1999-2018
Authors: Ma Ning , Yip Rowena , Lewis Sara , Dinani Amreen , Wyatt Christina , Crane Michael , Jirapatnakul Artit , Li Li , Aloman Costica , Bansal Meena B. , Dieterich Douglas , Wyatt Brooke , Yankelevitz David , Henschke Claudia , Branch Andrea D. 
Published: December 2022

AbstractBackground and aimsThe prevalence and etiology of liver fibrosis vary over time and impact racial/ethnic groups unevenly. This study measured time-trends and identified factors associated with advanced liver fibrosis in the U.S.MethodsStandardized methods were used to analyze data on 47,422 participants (≥ 20 years) in the National Health and Nutrition Examination Survey (1999-2018). Advanced liver fibrosis was defined as Fibrosis-4 ≥2.67 and/or Forns Index ≥6.9 and elevated ALT.ResultsThe estimated number of people with advanced liver fibrosis increased from 1.3 million (95% CI, 0.8-1.9) to 3.5 million (95% CI, 2.8-4.2), a nearly 3-fold increase. Prevalence was higher in non-Hispanic Black and Mexican American persons than in non-Hispanic White persons. In multivariable logistic regression analysis, cadmium was an independent risk factor in all racial/ethnic groups. Smoking and current excessive alcohol use were risk factors in most. Importantly, non-Hispanic Black persons had a distinctive set of risk factors compared to non-Hispanic White persons that included poverty (OR = 2.09; 95%CI, 1.44-3.03), and susceptibility to lead exposure (OR = 3.25; 95%CI, 1.95-5.43), but did not include diabetes (OR = 0.88; 95% CI, 0.61-1.27, P =0.52). Non-Hispanic Black persons were more likely to have high exposure to lead, cadmium, polychlorinated biphenyls, and poverty than Non-Hispanic White persons.ConclusionsThe number of people with advanced liver fibrosis has increased, creating a need to expand the liver care workforce. The risk factors for advanced fibrosis varied by racial/ethnicity. These variations provide useful information for the design of screening programs. Poverty and toxic exposures were associated with the high prevalence of advanced liver fibrosis in non-Hispanic Black persons and need to be addressed.Lay summaryBecause liver disease often produces few warning signs, simple and inexpensive screening tests that can be performed by non-specialists are needed to allow timely detection and linkage to care. This study shows that non-Hispanic Black persons have a distinctive set of risk factors that need to be taken into account when designing liver disease screening tests. Exposure to exogenous toxins may be especially important risk factors for advanced liver fibrosis in non-Hispanic Black persons.
Non-redundant dimethyl sulfoxide reductases influenceSalmonella entericaserotype Typhimurium anaerobic growth and virulence
Authors: Cruz E , Haeberle AL , Westerman TL , Durham ME , Suyemoto MM , Knodler LA , Elfenbein JR 
Published: December 2022

AbstractFacultative anaerobic enteric pathogens can utilize a diverse array of alternate electron acceptors to support anaerobic metabolism and thrive in the hypoxic conditions within the mammalian gut. Dimethyl sulfoxide (DMSO) is produced by methionine catabolism and can act as an alternate electron acceptor to support anaerobic respiration. The DMSO reductase complex consists of three subunits, DmsA, DmsB, and DmsC, and allows bacteria to grow anaerobically with DMSO as an electron acceptor. The genomes of non-typhoidalS. entericaencode three putativedmsABCoperons, but the impact of the apparent genetic redundancy in DMSO reduction on fitness of non-typhoidalS. entericaduring infection remains unknown. We hypothesized that DMSO reduction would be needed forS. entericaserotype Typhimurium (S. Typhimurium) to colonize the mammalian gut. We demonstrate aS.Typhimurium mutant with loss of function in all three putative DMSO reductases (ΔdmsA3) poorly colonizes the mammalian intestine when the microbiota are intact and when inflammation is absent. DMSO reduction enhances anaerobic growth through non-redundant contributions of two of the DMSO reductases. Furthermore, DMSO reduction influences the expression of the type-3 secretion systems needed for virulence. Collectively, our data demonstrate that the DMSO reductases ofS.Typhimurium are functionally non-redundant and suggest DMSO is a physiologically relevant electron acceptor that supportsS. entericafitness in the gut.
Toward SME digital transformation in the supply chain context: the role of structural social and human capital
Authors: Lang Le Dang , Behl Abhishek , Phuong Nguyen Ngoc Duy , Gaur Jighyasu , Dzung Nguyen Tien 
Published: December 2022

PurposeDigital transformation (DT) and supply chain resilience have received increasing attention. Structural social capital (SSC) and human capital (HC) have recently been identified as strategic resources for small and medium-sized enterprises (SMEs). While the significant role of entrepreneurial competencies (ECs), SME innovativeness (SMI) and technology adoption (TA) in driving business performance have been partially researched, no studies have simultaneously examined the effect of these resources and capabilities on SME business performance growth (BPG) under the lenses of a resource-based view (RBV) and dynamic capabilities (DCs) as well as in the context of DT. This study aims to clarify these unclear relationships.Design/methodology/approachThis study adopts established theoretical lenses, a mixed-methods approach and structural equation modeling (SEM) using a sample of 371 respondents who are top and middle SME managers in Vietnam.FindingsThe study discovers the significant and insignificant relationships between HC, SSC, ECs, SMI, TA and BPG besides providing a new measurement and reconciling existing measurements for the DT context. Some implications for driving SMEs' DT are also suggested.Originality/valueThis study is the first to thoroughly examine the effect of HC and SSC on SMEs' BPG through the mediating role of ECs, SMI and TA under RBV and DCs lenses in the DT context. The investigation is conducted in an emerging market, where DT implementation is in the process of being learned and experimented upon.
Management psychological characteristics and earnings management
Authors: Salehi Mahdi , Ahmed Jabbar Mohammed , Orfizadeh Saleh 
Published: December 2022

Purpose
This study investigates the relationship between management's psychological characteristics (managers' narcissism, overconfidence and managers' myopia) and earnings management in the pre-Islamic State of Iraq and Syria (ISIS) and post-ISIS eras.

Design/methodology/approach
A multivariate regression model was used to test the hypotheses. The research hypotheses were tested using a sample of all companies listed on the Iraqi Stock Exchange from 2014 to 2020.

Findings
Findings indicate a positive and significant relationship between managers' narcissism, overconfidence and myopia with accrual and real earnings management. According to the results, the ISIS weakens the relationship between managers' narcissism, managers' overconfidence and managers' myopia with accrual and real earnings management.

Originality/value
Because no study has addressed this issue in Iraq so far, the results of this research can provide helpful information for its users and improve the knowledge and science in this area.
On the safe-haven and hedging properties of Bitcoin: new evidence from COVID-19 pandemic
Authors: Abdelmalek Wafa , Benlagha Noureddine 
Published: December 2022

PurposeThis study aims to investigate the safe-haven and hedging properties of Bitcoin against a wide variety of conventional assets before and during the coronavirus disease 2019 (COVID-19) pandemic.Design/methodology/approachThis paper uses a smooth transition regression (STR) to jointly test the hedging properties of Bitcoin in normal conditions and Bitcoin's safe-haven properties in extreme stock market conditions.FindingsHighlighting the results, the authors show that Bitcoin is able to provide safe-haven feature during the COVID-19 pandemic period while Bitcoin serves as a hedge tool in the pre-COVID-19 pandemic period. The findings also show that the prowess of the safe-haven/hedge nature is sensitive to the type of the asset market and the time horizon when switching from daily to weekly frequency data.Originality/valueThis is one of the first studies that conduct a combined analysis of the safe-haven and hedging capabilities of Bitcoin against several asset classes using an STR method. This study uses the longest sample period to yet, allowing researchers to examine Bitcoin's safe-haven and hedging features both before and after the COVID-19 pandemic.
The impact of strategic emphasis on the readability of narrative information in annual reports
Authors: Noh Minyoung , Park Jimi 
Published: December 2022

Purpose
This study aims to examine how a firm’s strategic emphasis on value appropriation over value creation is associated with the readability of narrative disclosures in annual reports.

Design/methodology/approach
This study examines the effect of the strategic emphasis on annual report readability based on a total of 45,273 US firm-year (5,754 unique firms) observations for the period from 1994 to 2018. Strategic emphasis is measured as advertising expenses minus research and development expenses, scaled by sales and Bog index and various measures, such as the FOG, KINCAID and FLESCH index, are used to measure the annual report readability.

Findings
The authors find that the strategic emphasis on value appropriation over value creation is positively related to firms’ annual report readability. In addition, the positive effect of the strategic emphasis on value appropriation over value creation on annual report readability is more pronounced with high managerial ability.

Practical implications
With the continual effort of Securities and Exchange Commission regulation and IFRS updates to improve narrative disclosures, it is meaningful to provide evidence showing how managers shape narratives in annual reports by highlighting good news with easy-to-understand words, but also may establish a barrier to understanding by choosing to use long and complex words depending on their strategic emphasis.

Originality/value
The evidence suggests that a strategic emphasis between value appropriation and value creation and managerial ability is an important factor in shaping the readability of annual reports, which contributes to the management, accounting and finance literature that investigates the relationship between resource deployment (i.e. strategic emphasis) and textual properties of corporate financial disclosures (i.e. readability).
Impacts of maize hybrids with different nitrogen use efficiency on root‐associated microbiota based on distinct rhizosphere soil metabolites
Authors: Li Keke , Chen La , Shi Wenjun , Hu Conghui , Sha Ye , Feng Guozhong , Wang Entao , Chen Wenxin , Sui Xinhua , Mi Guohua 
Published: December 2022

AbstractPlant genotypes shape root‐associated microbiota that affect plant nutrient acquisition and productivity. It is unclear how maize hybrids modify root‐associated microbiota and their functions and relationship with nitrogen use efficiency (NUE) by regulating rhizosphere soil metabolites. Here, two N‐efficient (NE) (ZD958, DMY3) and two N‐inefficient (NIE) maize hybrids (YD9953, LY99) were used to investigate this issue under low N (60 kg N ha−1, LN) and high N (180 kg N ha−1, HN) field conditions. NE hybrids had higher yield than NIE hybrids under LN but not HN. NE and NIE hybrids recruited only distinct root‐associated bacterial microbiota in LN. The bacterial network stability was stronger in NE than NIE hybrids. Compared with NIE hybrids, NE hybrids recruited more bacterial taxa that have been described as plant growth‐promoting rhizobacteria (PGPR), and less related to denitrification and N competition; this resulted in low N2O emission and high rhizosphere NO3−‐N accumulation. NE and NIE hybrids had distinct rhizosphere soil metabolite patterns, and their specific metabolites were closely related to microbiota and specific genera under LN. Our findings reveal the relationships among plant NUE, rhizosphere soil metabolites, root‐associated microbiota, and soil nutrient cycling, and this information is informative for breeding NE crops.
Paid Leave for Fathers: Policy, Practice, and Reform
Authors: YANG Y. TONY , WALLINGTON SHERRIE FLYNT , MORAIN STEPHANIE 
Published: December 2022

Policy PointsGovernment policies that secure paid leave for all parents, regardless of gender, can reduce structural inequalities, while promoting fathers’ engagement in parenting.Such policies are likely to be most effective when they secure full, or almost full wage replacement, and when they provide incentives for fathers to take leave.Organizations must also participate in the culture shift, providing workplaces that encourage paternity leave rather than reinforcing the “male breadwinner” stigma.
Court date reminders reduce court nonappearance: A meta‐analysis
Authors: Zottola Samantha A. , Crozier William E. , Ariturk Deniz , Desmarais Sarah L. 
Published: December 2022

AbstractResearch summaryWe conducted a systematic review and meta‐analysis of studies that examined whether providing people with a postcard, phone call, or text message reminder of their court date reduces their likelihood of failing to appear in court. We included 12 studies (N = 79,255) that compared court appearance rates between groups of people who received a reminder to groups who did not receive a reminder. Results showed that reminders significantly reduce the odds of failure to appear in court. Further, charge type moderated reminder effectiveness; court reminders had a slightly larger effect in studies that did not include people with felony charges. However, the difference in effect size as a function of charge type was small and reminders significantly reduced the odds of failure to appear in both studies that did and did not include people with felony charges. In contrast, there was no evidence that retaining people who could not be contacted in a reminder treatment group (versus excluding them from the study or intentionally assigning them to the nonreminded control group) moderated reminder effectiveness. Finally, a narrative synthesis of studies revealed that studies using more rigorous designs generally produced smaller effects compared to studies with less rigorous designs and that effects did not differ systematically as a function of reminder formats (e.g., postcard, phone call) or frequencies (e.g., one reminder or multiple).Policy implicationsCourt date reminders effectively reduce failures to appear across studies, so they are an inexpensive tool for jurisdictions seeking to implement pretrial reform efforts. However, reminders offer only a modest reduction in failures to appear because they only address failures to appear that result from missing or forgetting information. Thus, reminders are not a panacea to court nonappearance. Jurisdictions should consider other programs and interventions as well. Courts could address low‐barrier nonappearances with reminders and then efficiently focus more involved resources to help more people get to court.