bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrepreneurs’ Decisions in Perceived Environmental Uncertainty
Authors: Zayadin Rana , Zucchella Antonella , Anand Amitabh , Jones Paul , Ameen Nisreen 
Published: April 2022

AbstractThis research advances the understanding of entrepreneurial decisions in the context of perceived uncertainty related to regional political instability. Using qualitative data from a sample of 29 entrepreneurs, we captured the entrepreneurs’ perceptions of uncertainty and how these perceptions informed their judgement and led to confidence in their decisions. The perceptions of uncertainty that influenced the entrepreneurs’ decision‐making were grouped into three main categories: efforts to understand changes in regional markets; efforts to understand changes in local markets; and identifying multiple and compounded layers of uncertainty. The entrepreneurs’ decisions were informed by the interactions between their perceptions of a dynamic and changing environment and their judgements about mobilizing resources in response to that environment. The findings of this research extend the current understanding of how entrepreneurs use judgement to arrive at decisions in contexts of uncertainty and highlight the dynamic relationship between individuals and context. The research has theoretical and practical implications for developing and leveraging entrepreneurial decision‐making in uncertain environments.
Steering consumers to lenders in residential real estate markets
Authors: Lopez Luis Arturo , McCoy Shawn J. , Sah Vivek 
Published: April 2022

AbstractUsing novel data on property listings that allow us to observe private information exchanges between real estate agents, we identify bidding constraints requiring financed buyers to obtain a prequalification letter from a seller‐preferred lender even if the buyers have been prequalified with other lenders. More than half of the steering activity is driven by sellers of foreclosed properties. We find evidence that steering increases the likelihood of sale but not that it drives borrowers to take out high‐cost or complex mortgages. However, steering‐kickback arrangements potentially crowd out buyers who rely on mortgage financing.
Sports‐related ocular injuries at a tertiary eye hospital in Australia: A 5‐year retrospective descriptive study
Authors: Ashraf Gizem , Arslan Janan , Crock Carmel , Chakrabarti Rahul 
Published: April 2022

AbstractObjectiveTo describe the demographics and outcomes of sports‐related ocular injuries in an Australian tertiary eye hospital setting.MethodsRetrospective descriptive study from the Royal Victorian Eye and Ear Hospital from 2015 to 2020. Patient demographics, diagnosis and injury causation were recorded from baseline and follow‐up. Outcomes included visual acuity (VA), intraocular pressure (IOP), ocular injury diagnosis, investigations and management performed.ResultsA total of 1793 individuals (mean age 28.67 ± 15.65 years; 80.42% males and 19.58% females) presented with sports‐related ocular trauma. The top three injury‐causing sports were soccer (n = 327, 18.24%), Australian rules football (AFL) (n = 306, 17.07%) and basketball (n = 215, 11.99%). The top injury mechanisms were projectile (n = 976, 54.43%) and incidental body contact (n = 506, 28.22%). The most frequent diagnosis was traumatic hyphaema (n = 725). Best documented VA was ≥6/12 at baseline in 84.8% and at follow‐up in 95.0% of cases.The greatest risk of globe rupture/penetration was associated with martial arts (odds ratio [OR] 16.22); orbital blow‐out fracture with skiing (OR 14.42); and hyphaema with squash (OR 4.18): P < 0.05 for all. Topical steroids were the most common treatment (n = 693, 38.7%). Computed tomography orbits/facial bones were the most common investigation (n = 184, 10.3%). The mean IOP was 16.1 mmHg; 103 (5.7%) cases required topical anti‐ocular hypertensives. Twenty‐six individuals (1.45%) required surgery with AFL contributing the most surgical cases (n = 5, 19.23%).ConclusionThe top three ocular injury causing sports were soccer, AFL and basketball. The most frequent injury was traumatic hyphaema. Projectiles posed the greatest risk.
Detection and identification of marine fish mislabeling in Guangzhou's supermarkets and sushi restaurants using DNA barcoding
Authors: Liu Bo , Yang Jing‐Wen , Liu Bao‐Suo , Zhang Nan , Guo Liang , Guo Hua‐Yang , Zhang Dian‐Chang 
Published: April 2022

AbstractIn this study, DNA barcoding was applied to identify the distinct species of fish products in Guangzhou supermarkets and sushi restaurants in order to confirm whether products were correctly labeled. Samples were analyzed using mitochondrial cytochrome C oxidase subunit I (CO I) gene as the target. Our results showed that the CO I gene of all 139 samples examined was successfully amplified by PCR. When sequenced, 30 samples (21.58%) were mislabeled as the wrong species, 11 samples had insufficient information provided on the label to determine if the labeling was correct (7.91%), and four samples failed sequencing (2.88%). We also found that the use of proper labels for fish products in sushi restaurants was higher than that in supermarkets. As a simple, rapid, and efficient technology, DNA barcoding can be widely used for species identification of fish products. Our work shows that regulation of the labeling of fish products, as we evaluated in Guangzhou and other markets in China, is needed on a global scale.
Impaired glucose tolerance is associated with enhanced postprandial pancreatic polypeptide secretion
Authors: Zhao Yanyun , Zhou Yue , Xiao Min , Huang Yajing , Qi Mengmeng , Kong Zili , Chi Jingwei , Che Kui , Lv Wenshan , Dong Bingzi , Wang Yangang 
Published: April 2022

AbstractBackgroundThe purpose of this study is to compare serum pancreatic polypeptide (PP), insulin, C‐peptide, and glucagon in different glucose tolerance stages; analyze the influencing factors of PP secretion; and further explore the role of PP in the pathogenesis of diabetes mellitus.MethodsData were collected from 100 subjects from hospital. According to the results of oral glucose tolerance test (OGTT), the subjects were divided into a normal glucose tolerance (NGT) group, an impaired glucose regulation (IGR) group, and a newly diagnosed type 2 diabetes mellitus (T2DM) group. PP and the related parameters were measured, and the area under the curve (AUC) 120 min after OGTT was calculated. AUCpp (AUC of PP) was used as the dependent variable and the potentially influencing factors were used as the independent variable for multiple linear regression analysis.ResultsPostprandial 60 min PP in the IGR group was higher than those in the NGT group (2973.80 [±547.49] pg·h/mL vs 2663.55 [±594.89] pg·h/mL, p < 0.05). AUCpp was significantly higher in the IGR group (428.76 pg·h/mL, 95% confidence interval [CI] [41.06 –816.46], p = 0.031) and newly diagnosed T2DM group (404.35 pg·h/mL, 95% CI [5.37–803.33], p = 0.047) than in the NGT group. AUCpp was negatively correlated with body mass index (BMI) (r = −0.235, p = 0.038) and positively correlated with postprandial 60 min blood glucose (r = 0.370, p = 0.001) and AUCbg (AUC of blood glucose) (r = 0.323, p = 0.007). Multiple linear regression analysis indicated that there was a linear correlation between BMI, AUCbg, and AUCpp (p = 0.004, p = 0.001), and the regression equation was calculated as: AUCpp = 6592.272 + 86.275 × AUCbg‐95.291 × BMI (R2 = 12.7%, p < 0.05).ConclusionsCompared with NGT subjects, IGR and T2DM patients have an enhanced postprandial PP secretion. In T2DMs, the secretion of PP is mainly affected by BMI and blood glucose.
Design and implementation of multiplexed amplicon sequencing panels to serve genomic epidemiology of infectious disease: A malaria case study
Authors: LaVerriere Emily , Schwabl Philipp , Carrasquilla Manuela , Taylor Aimee R. , Johnson Zachary M. , Shieh Meg , Panchal Ruchit , Straub Timothy J. , Kuzma Rebecca , Watson Sean , Buckee Caroline O. , Andrade Carolina M. , Portugal Silvia , Crompton Peter D. , Traore Boubacar , Rayner Julian C. , Corredor Vladimir , James Kashana , Cox Horace , Early Angela M. , MacInnis Bronwyn L. , Neafsey Daniel E. 
Published: April 2022

AbstractMultiplexed PCR amplicon sequencing (AmpSeq) is an increasingly popular application for cost‐effective monitoring of threatened species and managed wildlife populations, and shows strong potential for the genomic epidemiology of infectious disease. AmpSeq data from infectious microbes can inform disease control in multiple ways, such as by measuring drug resistance marker prevalence, distinguishing imported from local cases, and determining the effectiveness of therapeutics. We describe the design and comparative evaluation of two new AmpSeq assays for Plasmodium falciparum malaria parasites: a four‐locus panel (“4CAST”) composed of highly diverse antigens, and a 129‐locus panel (“AMPLseq”) composed of drug resistance markers, highly diverse loci for inferring relatedness, and a locus to detect Plasmodium vivax co‐infection. We explore the performance of each panel in various public health use cases with in silico simulations as well as empirical experiments. The 4CAST panel appears highly suitable for evaluating the number of distinct parasite strains within samples (complexity of infection), showing strong performance across a wide range of parasitaemia levels without a DNA pre‐amplification step. For relatedness inference, the larger AMPLseq panel performs similarly to two existing panels of comparable size, despite differences in the data and approach used for designing each panel. Finally, we describe an R package (paneljudge) that facilitates the design and comparative evaluation of genetic panels for relatedness estimation, and we provide general guidance on the design and implementation of AmpSeq panels for the genomic epidemiology of infectious disease.
Short‐ and long‐read metabarcoding of the eukaryotic rRNA operon: Evaluation of primers and comparison to shotgun metagenomics sequencing
Authors: Latz Meike A. C. , Grujcic Vesna , Brugel Sonia , Lycken Jenny , John Uwe , Karlson Bengt , Andersson Agneta , Andersson Anders F. 
Published: April 2022

AbstractHigh‐throughput sequencing‐based analysis of microbial diversity has evolved vastly over the last decade. Currently, the go‐to method for studying microbial eukaryotes is short‐read metabarcoding of variable regions of the 18S rRNA gene with <500 bp amplicons. However, there is a growing interest in applying long‐read sequencing of amplicons covering the rRNA operon for improving taxonomic resolution. For both methods, the choice of primers is crucial. It determines if community members are covered, if they can be identified at a satisfactory taxonomic level, and if the obtained community profile is representative. Here, we designed new primers targeting 18S and 28S rRNA based on 177,934 and 21,072 database sequences, respectively. The primers were evaluated in silico along with published primers on reference sequence databases and marine metagenomics data sets. We further evaluated a subset of the primers for short‐ and long‐read sequencing on environmental samples in vitro and compared the obtained community profile with primer‐unbiased metagenomic sequencing. Of the short‐read pairs, a new V6‐V8 pair and the V4_Balzano pair used with a simplified PCR protocol provided good results in silico and in vitro. Fewer differences were observed between the long‐read primer pairs. The long‐read amplicons and ITS1 alone provided higher taxonomic resolution than V4. Together, our results represent a reference and guide for selection of robust primers for research on and environmental monitoring of microbial eukaryotes.
Clinical outcomes of EGFR+/METamp+ vs. EGFR+/METamp‐ untreated patients with advanced non‐small cell lung cancer
Authors: Peng Kai‐Cheng , Su Jun‐Wei , Xie Zhi , Wang Han‐Min , Fang Mei‐Mei , Li Wen‐Feng , Chen Yu‐Qing , Guan Xu‐Hui , Su Jian , Yan Hong‐Hong , Zhang Xu‐Chao , Tu Hai‐Yan , Zhou Qing , Chen Hua‐Jun , Wu Yi‐Long , Yang Jin‐Ji 
Published: April 2022

AbstractBackgroundMET dysregulation has been implicated in the development of primary and secondary resistance to EGFR tyrosine kinase inhibitor (TKI) therapy. However, the clinicopathological characteristics and outcomes of patients harboring EGFR‐sensitive mutations and de novo MET amplifications still need to be explored.MethodsA total of 54 patients from our hospital with non‐small cell lung cancer harboring EGFR‐sensitive mutations and/or de novo MET amplifications were included in this study. Survival rates were estimated by the Kaplan–Meier method with log‐rank statistics. Lung cancer organoids (LCOs) were generated from patient‐derived malignant pleural effusion to perform drug sensitivity assays.ResultsFifty‐four patients with the appropriate clinicopathological characteristics were enrolled. MET FISH was performed in 40 patients who were stratified accordingly into two groups: EGFR+/METamp‐ (n = 22) and EGFR+/METamp + (n = 18). Survival rates for EGFR+/METamp‐ and EGFR+/METamp + patients respectively, were as follows: the median progression‐free survival (PFS) was 12.1 and 1.9 months (p<0.001); the median post‐progression overall survival (pOS) was 25.6 and 11.6 months (p = 0.023); the median overall survival (OS) was 33.2 and 12.7 months (p = 0.013). Drug testing conducted in LCOs derived from malignant pleural effusion from EGFR+/METamp + patients showed that dual targeted therapy was more effective than TKI monotherapy.ConclusionEGFR+/METamp + patients treated with first‐line TKI monotherapy had poor clinical outcomes. Dual targeted therapy showed potent anticancer activity in the LCO drug testing assay, suggesting that it is a promising first‐line treatment for EGFR+/METamp + patients. Randomized controlled trials are needed to further validate these results.
Methylation risk scores for childhood aeroallergen sensitization: Results from the LISA birth cohort
Authors: Kilanowski Anna , Chen Junyu , Everson Todd , Thiering Elisabeth , Wilson Rory , Gladish Nicole , Waldenberger Melanie , Zhang Hongmei , Celedón Juan C. , Burchard Esteban G. , Peters Annette , Standl Marie , Hüls Anke 
Published: April 2022

AbstractBackgroundEpigenomic (e.g., DNA methylation [DNAm]) changes have been hypothesized as intermediate step linking environmental exposures with allergic disease. Associations between individual DNAm at CpGs and allergic diseases have been reported, but their joint predictive capability is unknown.MethodsData were obtained from 240 children of the German LISA cohort. DNAm was measured in blood clots at 6 (N = 234) and 10 years (N = 227) using the Illumina EPIC chip. Presence of aeroallergen sensitization was measured in blood at 6, 10, and 15 years. We calculated six methylation risk scores (MRS) for allergy‐related phenotypes, like total and specific IgE, asthma, or any allergies, based on available publications and assessed their performances both cross‐sectionally (biomarker) and prospectively (predictor of the disease). Dose–response associations between aeroallergen sensitization and MRS were evaluated.ResultsAll six allergy‐related MRS were highly correlated (r > .86), and seven CpGs were included in more than one MRS. Cross‐sectionally, we observed an 81% increased risk for aeroallergen sensitization at 6 years with an increased MRS by one standard deviation (best‐performing MRS, 95% confidence interval = [43%; 227%]). Significant associations were also seen cross‐sectionally at 10 years and prospectively, though the effect of the latter was attenuated when restricted to participants not sensitized at baseline. A clear dose–response relationship with levels of aeroallergen sensitization could be established cross‐sectionally, but not prospectively.ConclusionWe found good classification and prediction capabilities of calculated allergy‐related MRS cross‐sectionally, underlining the relevance of altered gene‐regulation in allergic diseases and providing insights into potential DNAm biomarkers of aeroallergen sensitization.
Cerebrospinal fluid white cell count to red cell count ratio as a predictor of ventriculitis in patients with external ventricular drains
Authors: Brooks Michael , Duong Dannielle , Shivapathasundram Ganeshwaran , Sheridan Mark 
Published: April 2022

AbstractIntroductionExternal ventricular drain (EVD) associated ventriculitis is a complication of EVD placement associated with significant morbidity and mortality. Gold‐standard for EVD associated bacterial ventriculitis diagnosis involves cerebrospinal fluid (CSF) sampling from the EVD with microscopy, culture and sensitivity testing. The ratio of white blood cells to red blood cells has anecdotally been considered a predictive factor in diagnosing EVD associated ventriculitis, however no study has been done demonstrating this.MethodsA retrospective cross‐sectional study was designed to assess whether the ratio of CSF white blood cells to red blood cells could be used to diagnose EVD associated ventriculitis. Data was collected for all patients undergoing EVD insertion at a major neurosurgical unit in Sydney, Australia. A receiver operator characteristics (ROC) curve was used to determine if this ratio was useful, and Youden's index was calculated to determine the appropriate cut‐off point.ResultsThis sample of n = 157 consecutive patients a total of 29 patients were diagnosed with ventriculitis. The area under the ROC curve was significant (0.706, P <0.001), and Youden's index demonstrated an appropriate cut‐off point was a ratio of 1:106.DiscussionCSF parameters have long been considered predictive of EVD associated ventriculitis. We demonstrated that using a component of routine testing it is possible to accurately predict a ventriculitis diagnosis. As the ratio is used, it enables discrimination in a raised white blood cell count due to local trauma with interventricular bleeding.ConclusionCSF white blood cell to red blood cell ratio is an appropriate diagnostic test for ventriculitis.
Indonesia's response to the Belt and Road Initiative and the Indo‐Pacific: A pivotal state's hedging strategy
Authors: Yoshimatsu Hidetaka 
Published: April 2022

AbstractRegional politics surrounding Southeast Asia has exhibited significant developments with China's Belt and Road Initiative (BRI) and counter initiatives through the Indo‐Pacific concept. This article seeks to examine Indonesia's strategic reactions to such regional developments. It argues that Indonesia has exhibited policy responses to the BRI and the Indo‐Pacific concept by hedging against uncertainties created by China's economic prowess through the adoption of mutually contradictory policy options. Such a hedging strategy was present in various dimensions: adopting economic accommodation and economic diversification regarding the BRI; taking confrontational strategies in maritime security tensions with China while pursuing economic pragmatism for attracting BRI funds; and restraining reliance on China and its BRI by pushing forwards Association of Southeast Asian Nations' (ASEAN) regional initiative that uses the Indo‐Pacific term. The findings indicate that Indonesia's position is crucial for bolstering ASEAN's status as the main regional organization under evolving regional politics.
Crying in the first 12 months of life: A systematic review and meta‐analysis of cross‐country parent‐reported data and modeling of the “cry curve”
Authors: Vermillet Arnault‐Quentin , Tølbøll Katrine , Litsis Mizan Samouil , C. Skewes Joshua , Parsons Christine E. 
Published: April 2022

AbstractCrying is an ubiquitous communicative signal in infancy. This meta‐analysis synthesizes data on parent‐reported infant cry durations from 17 countries and 57 studies until infant age 12 months (N = 7580, 54% female from k = 44; majority White samples, where reported, k = 18), from studies before the end Sept. 2020. Most studies were conducted in the United States, the United Kingdom, and Canada (k = 32), and at the traditional cry “peak” (age 5–6 weeks), where the pooled estimate for cry and fuss duration was 126 mins (SD = 61), with high heterogeneity. Formal modeling of the meta‐analytic data suggests that the duration of crying remains substantial in the first year of life, after an initial decline.
Associations between cross‐racial friendships and children’s social and academic adjustment in racially diverse classrooms
Authors: Qi Hongyuan , Mikami Amori Yee , Owens Julie Sarno 
Published: April 2022

AbstractThis study examined bidirectional associations between cross‐racial friendships and children's social and academic adjustment. Participants were 583 elementary school‐age children in western Canada, or the midwestern United States (4–10 years; 279 girls; 143 Asian, 88 Black, 65 Hispanic or Latinx, 171 White, 116 mixed). Children's adjustment (social preference, academic enablers, academic performance) and friendship nominations (reciprocated, received, given) were measured in fall and spring over one school year from 2017 to 2018, or from 2018 to 2019. Regarding reciprocated nominations, fall adjustment positively predicted spring reciprocated cross‐racial friendships, but not vice‐versa. For received nominations, academic enablers and received cross‐racial friendship nominations were positively and bidirectionally related to one another. Fall same‐racial friendship nominations positively predicted spring academic performance and social preference. Effect sizes were small.
Bankers' remuneration reforms and new challenges
Authors: Zalewska Anna (Ania) 
Published: April 2022

AbstractResearch Question/IssueThe desire to structure bankers' remuneration in a way that it is risk sensitive and aligned with the long‐term incentives of their institutions was at the center of the post Global Financial Crisis (GFC) regulatory reforms. A decade later, it is unclear whether the reforms achieved what they were intended for and whether they have resulted in some unintended consequences. The issue of unintended consequences is particularly important given that the banking sector needs to embrace technological innovation (Fintech) and the sustainable banking agenda.Research Findings/InsightsWe are still far from understanding the real costs and benefits of the remuneration reforms because it is difficult to isolate the impact of remuneration restrictions from the impact other regulations and policies had on restricting risk taking, banking structures and bonus culture. However, even if it is questionable whether the remuneration reforms contributed significantly towards improving the stability of the banking sector, they seem unsuitable for promoting Fintech and the sustainable banking agenda.Theoretical/Academic ImplicationsThe post‐GFC remuneration reforms may not sufficiently align bankers with stakeholders' interests which is essential to promote adoption of Fintech and sustainable banking agenda.Practitioner/Policy ImplicationsThe lack of in‐depth understanding of the effects of the remuneration reforms creates a barrier to understand the impact of the reforms on how banks innovate to adopt Fintech and the sustainable banking agenda. If the existing remuneration regulation limits the openness to innovation and strategic change, then the regulation needs to be revisited and modified.