bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Provisional notes on the postcolony’ in Congo studies: an overview of themes and debates
Authors: Pype Katrien 
Published: January 2022

AbstractThis article considers the uptake of Achille Mbembe’s article ‘Provisional notes on the postcolony’ (1992), the book De la Postcolonie: essai sur l’imagination politique dans l’Afrique contemporain (2000) and its translated version, On the Postcolony (2001), in Congo studies. ‘Congo’ here is a shorthand for the current Democratic Republic of Congo, formerly known as Zaire. The article is concerned with the ways in which these two English-language texts (and their original French versions) figure in the social sciences and the humanities, specifically in the field of study relating to Zairian/Congolese society and culture. It becomes clear that the theme of mutual entanglements of commandement (power) and citizens not only influences political studies but also structures Congo scholarship on economy and governance, popular culture and erotics. The article ends with some reflections on academic writing about Congo, the limited uptake of ‘Provisional notes’ and On the Postcolony in religious studies, questions about ethics and scientific writing about political postcolonial cultures, and especially the necessity to historicize the postcolony.
“Illegitimate Children”: The Tunisian New Left and the Student Question, 1963–1975
Authors: Jebari Idriss 
Published: January 2022

AbstractThe alliance between the leftist movement Perspectives Tunisiennes and university students delivered sustained opposition and repeated protests against Bourguiba's regime in the 1960s and 1970s. This article argues that these groups were driven by the “student question,” a counterproject for Tunisian national development that opposed the vision of liberal bourgeois modernity espoused by Bourguiba's reforms of elitism through education and depoliticization. Instead, the student question was fleshed out in the group's periodical, envisaging the emancipation of Tunisian subjects and their entitlement to citizenship and political participation, and how the struggle of students would sweep the whole country. Drawing on the movement's journal and memoirs of four former Tunisian leftists, I trace how Perspectives navigated the regime's repression in 1968 and 1972–75, and how two successive generations of leftists emerged with different ideological reference points. In so doing, this article takes seriously the political imagination of this group during the global 1960s and 1970s, while conceiving ways to reintegrate silenced memories and histories into the mainstream of Tunisian historiography after the 2011 revolution.
The impact of meteorological factors and PM2.5 on COVID-19 transmission
Authors: Zhou Nan , Dai HaoYun , Zha WenTing , Lv Yuan 
Published: January 2022

Abstract
In this study, we analysed the relationship between meteorological factors and the number of patients with coronavirus disease 2019 (COVID-19). The study period was from 12 April 2020 to 13 October 2020, and daily meteorological data and the daily number of patients with COVID-19 in each state of the United States were collected. Based on the number of COVID-19 patients in each state of the United States, we selected four states (California, Florida, New York, Texas) for analysis. One-way analysis of variance ( ANOVA), scatter plot analysis, correlation analysis and distributed lag nonlinear model (DLNM) analysis were used to analyse the relationship between meteorological factors and the number of patients with COVID-19. We found that the significant influencing factors of the number of COVID-19 cases differed among the four states. Specifically, the number of COVID-19 confirmed cases in California and New York was negatively correlated with AWMD (P < 0.01) and positively correlated with AQI, PM2.5 and TAVG (P < 0.01) but not significantly correlated with other factors. Florida was significantly correlated with TAVG (positive) (P < 0.01) but not significantly correlated with other factors. The number of COVID-19 cases in Texas was only significantly negatively associated with AWND (P < 0.01). The influence of temperature and PM2.5 on the spread of COVID-19 is not obvious. This study shows that when the wind speed was 2 m/s, it had a significant positive correlation with COVID-19 cases. The impact of meteorological factors on COVID-19 may be very complicated. It is necessary to further explore the relationship between meteorological factors and COVID-19. By exploring the influence of meteorological factors on COVID-19, we can help people to establish a more accurate early warning system.
CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment
Authors: Giallongo Cesarina , Dulcamare Ilaria , Tibullo Daniele , Del Fabro Vittorio , Vicario Nunzio , Parrinello Nunziatina , Romano Alessandra , Scandura Grazia , Lazzarino Giacomo , Conticello Concetta , Li Volti Giovanni , Amorini Angela Maria , Musumeci Giuseppe , Di Rosa Michelino , Polito Francesca , Oteri Rosaria , Aguennouz M’hammed , Parenti Rosalba , Di Raimondo Francesco , Palumbo Giuseppe A. 
Published: January 2022

AbstractMesenchymal stromal cells (MSCs) within the protective microenvironment of multiple myeloma (MM) promote tumor growth, confer chemoresistance and support metabolic needs of plasma cells (PCs) even transferring mitochondria. In this scenario, heterocellular communication and dysregulation of critical signaling axes are among the major contributors to progression and treatment failure. Here, we report that myeloma MSCs have decreased reliance on mitochondrial metabolism as compared to healthy MSCs and increased tendency to deliver mitochondria to MM cells, suggesting that this intercellular exchange between PCs and stromal cells can be consider part of MSC pro-tumorigenic phenotype. Interestingly, we also showed that PCs promoted expression of connexin 43 (CX43) in MSCs leading to CXCL12 activation and stimulation of its receptor CXCR4 on MM cells favoring protumor mitochondrial transfer. Consistently, we observed that selective inhibition of CXCR4 by plerixafor resulted in a significant reduction of mitochondria trafficking. Moreover, intracellular expression of CXCR4 in myeloma PCs from BM biopsy specimens demonstrated higher CXCR4 colocalization with CD138+ cells of non-responder patients to bortezomib compared with responder patients, suggesting that CXCR4 mediated chemoresistance in MM. Taken together, our data demonstrated that CXCL12/CXCR4 axis mediates intercellular coupling thus suggesting that the myeloma niche may be exploited as a target to improve and develop therapeutic approaches.
Anxiety, home blood pressure monitoring, and cardiovascular events among older hypertension patients during the COVID-19 pandemic
Authors: Zhang Shuyuan , Zhong Yixuan , Wang Lixin , Yin Xinhua , Li Yufeng , Liu Yunlan , Dai Qiuyan , Tong Anli , Li Dongfeng , Zhang Liangqing , Li Ping , Zhang Guohui , Huang Rongjie , Liu Jinguang , Zhao Luosha , Yu Jing , Zhang Xinjun , Yang Li , Cai Jun , Zhang Weili ,   On behalf of the STEP Study Group
Published: January 2022

AbstractThe global coronavirus disease 2019 (COVID-19) pandemic has led to a health crisis. It remains unclear how anxiety affects blood pressure (BP) and cardiovascular risk among older patients with hypertension. In this study, we extracted longitudinal data on home BP monitored via a smartphone-based application in 3724 elderly patients with hypertension from a clinical trial (60–80 years; 240 in Wuhan and 3484 in non-Wuhan areas) to examine changes in morning BP during the COVID-19 outbreak in China. Anxiety was evaluated using Generalized Anxiety Disorder-7 item scores. Changes in morning systolic BP (SBP) were analyzed for five 30-day periods during the pandemic (October 21, 2019 to March 21, 2020), including the pre-epidemic, incubation, developing, outbreak, and plateau periods. Data on cardiovascular events were prospectively collected for one year. A total of 262 individuals (7.0%) reported an increased level of anxiety, and 3462 individuals (93.0%) did not. Patients with anxiety showed higher morning SBP than patients without anxiety, and the between-group differences in SBP change were +1.2 mmHg and +1.7 mmHg during the outbreak and plateau periods (P < 0.05), respectively. The seasonal BP variation in winter among patients with anxiety was suppressed during the pandemic. Anxious patients had higher rates of uncontrolled BP. During the 1-year follow-up period, patients with anxiety had an increased risk of cardiovascular events with a hazard ratio of 2.47 (95% confidence interval, 1.10–5.58; P = 0.03). In summary, COVID-19-related anxiety was associated with a short-term increase in morning SBP among older patients and led to a greater risk of cardiovascular events. (ClinicalTrials. gov number, NCT03015311).
Magnetic monopole density and antiferromagnetic domain control in spin-ice iridates
Authors: Pearce M. J. , Götze K. , Szabó A. , Sikkenk T. S. , Lees M. R. , Boothroyd A. T. , Prabhakaran D. , Castelnovo C. , Goddard P. A. 
Published: January 2022

AbstractMagnetically frustrated systems provide fertile ground for complex behaviour, including unconventional ground states with emergent symmetries, topological properties, and exotic excitations. A canonical example is the emergence of magnetic-charge-carrying quasiparticles in spin-ice compounds. Despite extensive work, a reliable experimental indicator of the density of these magnetic monopoles is yet to be found. Using measurements on single crystals of Ho2Ir2O7 combined with dipolar Monte Carlo simulations, we show that the isothermal magnetoresistance is highly sensitive to the monopole density. Moreover, we uncover an unexpected and strong coupling between the monopoles on the holmium sublattice and the antiferromagnetically ordered iridium ions. These results pave the way towards a quantitative experimental measure of monopole density and demonstrate the ability to control antiferromagnetic domain walls using a uniform external magnetic field, a key goal in the design of next-generation spintronic devices.
Controlling the helicity of π-conjugated oligomers by tuning the aromatic backbone twist
Authors: Bedi Anjan , Manor Armon Amit , Diskin-Posner Yael , Bogosalvsky Benny , Gidron Ori 
Published: January 2022

AbstractThe properties of π-conjugated oligomers and polymers are commonly controlled by side group engineering, main chain engineering, or conformational engineering. The last approach is typically limited to controlling the dihedral angle around the interring single bonds to prevent loss of π-conjugation. Here we propose a different approach to conformational engineering that involves controlling the twist of the aromatic units comprising the backbone by using a tether of varying lengths. We demonstrate this approach by synthesizing an inherently twisted building unit comprised of helically locked tethered acenes, bearing acetylene end-groups to enable backbone extension, which was applied in a series of nine helical oligomers with varying backbone length and twist. We find that the optical and electronic properties of π-conjugated systems may be determined by the additive, antagonistic, or independent effects of backbone length and twist angle. The twisted oligomers display chiral amplification, arising from the formation of secondary helical structures.
A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
Authors: Yuan Qian , Ren Qian , Li Li , Tan Huishi , Lu Meizhi , Tian Yuan , Huang Lu , Zhao Boxin , Fu Haiyan , Hou Fan Fan , Zhou Lili , Liu Youhua 
Published: January 2022

AbstractLoss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it as a therapeutic remedy. Here we report the discovery of a Klotho-derived peptide 1 (KP1) protecting kidneys by targeting TGF-β signaling. By screening a series of peptides derived from human Klotho protein, we identified KP1 that repressed fibroblast activation by binding to TGF-β receptor 2 (TβR2) and disrupting the TGF-β/TβR2 engagement. As such, KP1 blocked TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinases. In mouse models of renal fibrosis, intravenous injection of KP1 resulted in its preferential accumulation in injured kidneys. KP1 preserved kidney function, repressed TGF-β signaling, ameliorated renal fibrosis and restored endogenous Klotho expression. Together, our findings suggest that KP1 recapitulates the anti-fibrotic action of Klotho and offers a potential remedy in the fight against fibrotic kidney diseases.
Real-space observation of incommensurate spin density wave and coexisting charge density wave on Cr (001) surface
Authors: Hu Yining , Zhang Tianzhen , Zhao Dongming , Chen Chen , Ding Shuyue , Yang Wentao , Wang Xu , Li Chihao , Wang Haitao , Feng Donglai , Zhang Tong 
Published: January 2022

AbstractIn itinerant magnetic systems, a spin density wave (SDW) state can be induced by Fermi surface nesting and electron-electron interaction. It may intertwine with other orders such as charge density wave (CDW), while their relation is still yet to be understood. Here via spin-polarized scanning tunneling microscopy, we directly observed long-range spin modulation on Cr(001) surface, which corresponds to the well-known incommensurate SDW of bulk Cr. It displays 6.0 nm in-plane period and anti-phase behavior between adjacent (001) planes. Meanwhile, we simultaneously observed the coexisting CDW with half the period of SDW. Such SDW/CDW have highly correlated domain structures and are in-phase. Surprisingly, the CDW displays a contrast inversion around a density-of-states dip at −22 meV, indicating an anomalous CDW gap opened below EF. These observations support that the CDW is a secondary order driven by SDW. Our work is not only a real-space characterization of incommensurate SDW, but also provides insights on how SDW and CDW coexist.
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag
Authors: Liang Shun-Qing , Liu Pengpeng , Smith Jordan L. , Mintzer Esther , Maitland Stacy , Dong Xiaolong , Yang Qiyuan , Lee Jonathan , Haynes Cole M. , Zhu Lihua Julie , Watts Jonathan K. , Sontheimer Erik J. , Wolfe Scot A. , Xue Wen 
Published: January 2022

AbstractAnalysis of off-target editing is an important aspect of the development of safe nuclease-based genome editing therapeutics. in vivo assessment of nuclease off-target activity has primarily been indirect (based on discovery in vitro, in cells or via computational prediction) or through ChIP-based detection of double-strand break (DSB) DNA repair factors, which can be cumbersome. Herein we describe GUIDE-tag, which enables one-step, off-target genome editing analysis in mouse liver and lung. The GUIDE-tag system utilizes tethering between the Cas9 nuclease and the DNA donor to increase the capture rate of nuclease-mediated DSBs and UMI incorporation via Tn5 tagmentation to avoid PCR bias. These components can be delivered as SpyCas9-mSA ribonucleoprotein complexes and biotin-dsDNA donor for in vivo editing analysis. GUIDE-tag enables detection of off-target sites where editing rates are ≥ 0.2%. UDiTaS analysis utilizing the same tagmented genomic DNA detects low frequency translocation events with off-target sites and large deletions in vivo. The SpyCas9-mSA and biotin-dsDNA system provides a method to capture DSB loci in vivo in a variety of tissues with a workflow that is amenable to analysis of gross genomic alterations that are associated with genome editing.
Activation of the plant mevalonate pathway by extracellular ATP
Authors: Cho Sung-Hwan , Tóth Katalin , Kim Daewon , Vo Phuc H. , Lin Chung-Ho , Handakumbura Pubudu P. , Ubach Albert Rivas , Evans Sterling , Paša-Tolić Ljiljana , Stacey Gary 
Published: January 2022

AbstractThe mevalonate pathway plays a critical role in multiple cellular processes in both animals and plants. In plants, the products of this pathway impact growth and development, as well as the response to environmental stress. A forward genetic screen of Arabidopsis thaliana using Ca2+-imaging identified mevalonate kinase (MVK) as a critical component of plant purinergic signaling. MVK interacts directly with the plant extracellular ATP (eATP) receptor P2K1 and is phosphorylated by P2K1 in response to eATP. Mutation of P2K1-mediated phosphorylation sites in MVK eliminates the ATP-induced cytoplasmic calcium response, MVK enzymatic activity, and suppresses pathogen defense. The data demonstrate that the plasma membrane associated P2K1 directly impacts plant cellular metabolism by phosphorylation of MVK, a key enzyme in the mevalonate pathway. The results underline the importance of purinergic signaling in plants and the ability of eATP to influence the activity of a key metabolite pathway with global effects on plant metabolism.
Effectiveness of protection areas in safeguarding biodiversity and ecosystem services in Tibet Autonomous Region
Authors: Xu Kaipeng , Wang Xiahui , Wang Jinnan , Wang Jingjing , Ge Rongfeng , Tian Rensheng , Chai Huixia , Zhang Xin , Fu Le 
Published: January 2022

AbstractThe Tibet Autonomous Region of China constitutes a unique and fragile ecosystem that is increasingly influenced by development and global climate change. To protect biodiversity and ecosystem services in Tibet, the Chinese government established a system of nature reserves at a significant cost; however, the effectiveness of nature reserves at protecting both—biodiversity and ecosystem service functions in Tibet is not clear. To determine the success of existing nature reserves, we determined importance areas for the conservation of mammal, plant, bird, amphibian, and reptile species, and for the protection of ecosystem service functions. The results indicated that important conservation areas for endangered plants were mainly distributed in the southern part of Nyingchi City, and for endangered animals, in the southern part of Nyingchi and Shannan Cities. Extremely important conservation areas for ecosystem service functions of carbon sequestration, water and soil protection, and flood regulation were mainly distributed in the southern part of Nyingchi and Shannan Cities, northern and southeastern parts of Nagqu City, and southern part of Ngari area. Based on an analysis of spatial overlap in protection areas, we conclude that existing natural reserves need to be expanded, and new ones need to be established to better protect biodiversity in Tibet Autonomous Region.
Stories of intentional action mobilise climate policy support and action intentions
Authors: Sabherwal Anandita , Shreedhar Ganga 
Published: January 2022

AbstractWhat makes a climate story effective? We examined if short fiction stories about everyday pro-environmental behaviours motivate climate policy support, and individual and collective climate action in a nationally representative experiment (N = 903 UK adults). The story featuring protagonists driven by pro-environmental intentions (i.e., the intentional environmentalist narrative) increased participants’ support for pro-climate policies and intentions to take both individual and collective pro-environmental actions, more so than did stories featuring protagonists whose pro-environmental behaviours were driven by intentions to gain social status, to protect their health, and a control story. Participants’ stronger feelings of identification with the protagonist partially explained these effects of the intentional environmentalist narrative. Results highlight that narrating intentional, rather than unintentional, pro-environmental action can enhance readers’ climate policy support and intentions to perform pro-environmental action. Therefore, the intentions driving pro-environmental action may have implications for the extent to which observes identify with the actor and take pro-environmental action themselves.
Human transgenerational observations of regular smoking before puberty on fat mass in grandchildren and great-grandchildren
Authors: Golding Jean , Gregory Steve , Northstone Kate , Pembrey Marcus , Watkins Sarah , Iles-Caven Yasmin , Suderman Matthew 
Published: January 2022

AbstractPreviously, using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) we showed that sons of fathers who had started smoking regularly before puberty (< 13 years) had increased fat mass during childhood, adolescence, and early adulthood. We now show that if the paternal grandfather had started smoking pre-puberty, compared with later in childhood (13–16 years), his granddaughters, but not grandsons, had evidence of excess fat mass at two ages: mean difference + 3.54 kg; (P with 1-tailed test) = 0.043 at 17 years, and + 5.49 kg; (P1 = 0.016) at age 24. When fathers of maternal grandfathers had started smoking pre-puberty, their great-granddaughters, but not great-grandsons, had excess body fat: + 5.35 kg (P1 = 0.050) at 17, and + 6.10 kg (P1 = 0.053) at 24 years. Similar associations were not found with lean mass, in a sensitivity analysis. To determine whether these results were due to the later generations starting to smoke pre-puberty, further analyses omitted those in subsequent generations who had smoked regularly from < 13 years. The results were similar. If these associations are confirmed in another dataset or using biomarkers, this will be one of the first human demonstrations of transgenerational effects of an environmental exposure across four generations.
Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders
Authors: Kolla Nathan J. , Boileau Isabelle , Bagby R. Michael 
Published: January 2022

AbstractBorderline personality disorder (BPD) and antisocial personality disorder (ASPD) are the two most frequently diagnosed and researched DSM-5 personality disorders, and both are characterized by high levels of trait neuroticism. Fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system (ECS), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. We hypothesized that prefrontal cortex (PFC) FAAH binding would relate to trait neuroticism in personality disorders. Thirty-one individuals with personality disorders (20 with BPD and 11 with ASPD) completed the investigation. All participants completed the revised NEO Personality Inventory, which yields standardized scores (e.g., T scores) for the traits of neuroticism, openness, conscientiousness, agreeableness, and extraversion. All participants were medication free and were not utilizing illicit substances as determined by drug urinalysis. Additionally, none of the participants had a comorbid major depressive episode, bipolar disorder, psychotic disorder, or substance use disorder. Each participant underwent one [11C]CURB PET scan. Consistent with our hypothesis, neuroticism was positively correlated with PFC FAAH binding (r = 0.42, p = 0.021), controlling for genotype. Neuroticism was also positively correlated with dorsal putamen FAAH binding (r = 0.53, p = 0.0024), controlling for genotype. Elevated brain FAAH is an endophenotype for high neuroticism in BPD and ASPD. Novel pharmacological therapeutics that inhibit FAAH could emerge as potential new treatments for BPD and ASPD with high neuroticism.