bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining the value proposition in diagnostic technology: challenges and opportunities for its understanding and development – a review with a multiperspective reflective analysis
Authors: Soukup Tayana , Zamora-Talaya Bernarda , Bahadori Shayan , Luxardo Rosario , Kierkegaard Patrick , Butt Omar , Kettley-Linsell Hannah , Savva Katerina-Vanessa , Micocci Massimo , Zhou Shanshan , Newman Simon , Walne Simon , Peters Christopher J. , Gordon Adam , Ni Melody , Buckle Peter , Hanna George B. ,   NIHR HRC IVD PPIE Team
Published: February 2025

BackgroundThe Value Proposition (VP) in diagnostic technology serves as a “positioning statement” outlining the unique benefits, costs, and differentiation an innovation under development offers to healthcare organizations and its ability to effectively deliver these advantages in comparison to current interventions in the market. Despite its significance however, VP lacks a universally accepted definition, which is compounded by the diversity of technologies, their applications, and the varying needs of stakeholders. This paper aims to address this gap by offering a detailed conceptual analysis, revised definition of VP, and actionable recommendations for advancing VP development.MethodologyWe conducted a targeted narrative review, focusing on literature explicitly defining VPs in diagnostic technologies. Using Ovid’s Medline and Embase databases, we identified 19 relevant papers, of which only 5 provided explicit VP definitions. Our analysis incorporated principles of team science, encompassing reflective and thematic analyses of (1) interdisciplinary co-author discussions enabling us to weave together diverse insights into a cohesive exploration of the topic, and (2) MTech’s publicly available set of anonymised responses from NHS Associates, to capture the perspectives of the decision-makers and further enhance depth and breadth of our discourse.Results and discussionOur findings highlight the multifaceted nature of VP and its primary hurdles: inadequate identification of unmet needs and insufficient recognition of key stakeholders. We synthesized the evolution of VP definitions and explored the importance of unmet needs in their development, guided by frameworks, such as the Health Technology Navigation Pathway Tool, to ensure VPs meet both the pragmatic and aspirational goals of the healthcare. Thematic insights revealed opportunities for addressing these barriers through implementation science and collaborative strategies. This multi-perspective approach provided a conceptual examination of VP, enabling integration of varied viewpoints and insights.ConclusionBy employing team science principles and reflective analysis, we introduced a revised definition of VP and a set of actionable recommendations to guide VP development in diagnostics. These findings highlight the importance of addressing stakeholder diversity, unmet needs, and the intricacies of blending interdisciplinary perspectives to advance the field.
Molecular phylogenetic analyses reveal multiple long-distance dispersal events and extensive cryptic speciation in Nervilia (Orchidaceae), an isolated basal Epidendroid genus
Authors: Gale Stephan W. , Li Jihong , Suddee Somran , Traiperm Paweena , Peter Craig I. , Buruwate Tomas , Crain Benjamin J. , McCormick Melissa K. , Whigham Dennis F. , Musthofa Arni , Gogoi Khyanjeet , Ito Katsura , Minamiya Yukio , Fukuda Tatsuya , Landrein Sven , Yukawa Tomohisa 
Published: February 2025

IntroductionThe terrestrial orchid genus Nervilia is diagnosed by its hysteranthous pattern of emergence but is nested among leafless myco-heterotrophic lineages in the lower Epidendroideae. Comprising ca. 80 species distributed across Africa, Asia and Oceania, the genus remains poorly known and plagued by vague and overlapping species circumscriptions, especially within each of a series of taxonomically intractable species complexes. Prior small-scale, exploratory molecular phylogenetic analyses have revealed the existence of cryptic species, but little is otherwise understood of origin, the scale and timing of its biogeographic spread, or the palaeoclimatic factors that have shaped its ecology and given rise to contemporary patterns of occurrence.MethodsHere, we sample widely throughout the generic range, including 45 named taxa and multiple accessions referable to several widespread ‘macrospecies’, as well as material of equivocal identity and probable undescribed status, for the first time enabling an evaluation of taxonomic boundaries at both species and sectional level. Using nuclear (ITS) and plastid (matK, trnL-F) sequence data, we conduct phylogenetic (maximum parsimony and Bayesian inference) and ancestral area analysis to infer relationships and resolve probable origin and colonisation routes.ResultsThe genus is strongly supported as monophyletic, as are each of its three sections. However, the number of flowers in the inflorescence and other floral characters are poor indicators of sectional affinity. Dated ancestral area analysis supports an origin in Africa in the Early Oligocene, with spread eastwards to Asia occurring in the Late Miocene, plausibly via the Gomphotherium land bridge at a time when it supported woodland and savanna ecosystems.DiscussionTaxonomic radiation in Asia within the last 8 million years ties in with dramatic Himalayan-Tibetan Plateau uplift and associated intensification of the Asia monsoon. Multiple long-range migrations appear to have occurred thereafter, as the genus colonised Malesia and Oceania from the Pliocene onwards. The bulk of contemporary species diversity is relatively recent, potentially explaining the ubiquity of cryptic speciation, which leaves numerous species overlooked and unnamed. Widespread disjunct species pairs hint at high mobility across continents, extinction and a history of climate-induced vicariance. Persistent taxonomic challenges are highlighted.
Prenatal alcohol exposure before pregnancy awareness: a thematic analysis of online forum comments and misinformation
Authors: Frennesson Nessie Felicia , Merouani Youssouf , Barnett Julie , Attwood Angela , Zuccolo Luisa , McQuire Cheryl 
Published: February 2025

BackgroundMany women consume alcohol while pregnant before they are aware of the pregnancy, raising concerns about potential harms to the developing fetus. Official guidelines in the United Kingdom recommend abstinence throughout pregnancy, and many women turn to online forums for reassurance and information. However, online forums can also become a source of misinformation, potentially increasing confusion and anxiety among women who have consumed alcohol before pregnancy awareness. This study explored discussions about alcohol consumption before pregnancy awareness on Mumsnet to understand the nature of peer response and assess the accuracy of information against official health guidelines and the scientific literature.MethodsA thematic analysis was conducted on 71 thread starts and 1,281 comments from Mumsnet. Data was collected via web scraping, followed by manual screening. Themes were identified, and information-sharing posts were fact-checked against scientific evidence and guidelines.ResultsTwo overarching themes with five sub-themes emerged: “Type of reassurance offered”, where users offered reassurance to alleviate worries, and “Reactions to reassurance”, where some users appeared reassured while others did not. While many found reassurance, fact-checking revealed that the majority of the information was inaccurate, often underestimating the risks of prenatal alcohol exposure.ConclusionsOnline forums may provide a source of peer support to those who have consumed alcohol before pregnancy awareness but frequently spread misinformation about alcohol use in early pregnancy. Health professionals should ensure pregnant women have access to accurate information alongside appropriate support to reduce anxiety and avoid the spread of harmful misinformation.
Enhancing constituent estimation in nucleic acid mixture models using spectral annealing inference and MS/MS information
Authors: Tomono Taichi , Hara Satoshi , Iida Junko , Washio Takashi 
Published: February 2025

Mass spectrometry (MS) is a powerful analytical technique employed for a variety of applications including drug development, quality assurance, food inspection, and monitoring environmental pollutants. Recently, in the production of actively developed antibody and nucleic acid pharmaceuticals, impurities with various modifications have been generated. These impurities can lead to a decrease in drug stability, pharmacokinetics, and efficacy, making it crucial to distinguish between them. We previously modeled mass spectrometry for each possible number of constituents in a sample, using parameters such as monoisotopic mass and ion counts, and employed stochastic variational inference to determine the optimal parameters and the maximum posterior probability for each model. By comparing the maximum posterior probabilities among models, we selected the optimal number of constituents and inferred their corresponding monoisotopic masses and ion counts. However, MS spectra are sparse and predominantly flat, which can lead to vanishing gradients when using simple optimization techniques. To solve this problem, using MCMC as in our previous studies would take a very long time. To address this difficulty, in this study, we blur the comparative spectra and gradually reduce the blur to prevent vanishing gradients while inferring accurate values. Furthermore, we incorporate MS/MS spectra into the model to increase the amount of information available for inference, thereby improving the accuracy of parameter inference. This modification improved the mass error from an average of 1.348 Da–0.282 Da. Moreover, the required time, even including the processing of additional five MS/MS spectra, was reduced to less than half.
Production of Nd and Nd–Fe Alloys from NdCl3 by Calciothermic Reduction
Authors: Yu Joo-Won , Chung Yeon-Jun , Wang Jei-Pil 
Published: February 2025

This study presents a metallothermic reduction mechanism for fabricating Nd and Nd–Fe alloys at 850–1050 °C using anhydrous NdCl3 and Ca, which have relatively low melting points. Our method decreased the process temperature while improving the recovery rate of Nd using the thermodynamic parameters of the CaCl2–KCl–NaCl and Nd–Fe liquid solutions. To reduce the activity of the product (CaCl2), the optimal composition of the CaCl2–KCl–NaCl molten salt was XCaCl2=0.4 (XKCl:XNaCl=6:4). The molten metal bath (Nd or Nd–Fe) that formed at the bottom of the reaction zone during Nd and Nd–Fe alloy production absorbed metal particles generated in the molten salt during the reaction, thereby facilitating ingot formation. In Nd produced at 1050 °C using 1.2× the stoichiometric amount (by mass) of Ca, the Nd recovery rate was 97.0%. Moreover, in the Nd–Fe alloys produced at 1050 °C targeting eutectic compositions, the Nd recovery rate was 96.3%. Increased Fe contents in the Nd–Fe liquid solution reduced the Nd recovery rates, and the Nd–Fe alloy (Nd recovery rate: 89.8%) was produced at 850 °C, suggesting the possibility of increasing the energy efficiency of the Nd production process. The Nd–Fe alloy produced through this proposed process could be used as a raw material in the NdFeB strip casting process.
Parameter Design for Inter-Satellite Laser Link Acquisition Under Weak Light Conditions
Authors: Zhao Mengyang , Shen Jia , Wang Juan , Li Pan , Gao Ruihong , Luo Ziren 
Published: February 2025

For the Taiji program or other LISA-like space-based gravitational wave (GW) detection missions, establishing laser links is a prerequisite for entering the normal science mode. There has been a lack of in-depth research on inter-satellite link acquisition under weak light and low-speed conditions. In this paper, we comprehensively analyze the impact of key parameters, including scan speed, track width, acquisition camera integration time, and jitter, on the acquisition process. By introducing laser spot location error under weak light conditions, we derive an analytical expression for the acquisition failure probability. Focusing on variations in scan speed and track width and carefully selecting the appropriate acquisition camera integration time, we then simulate the actual acquisition process to closely replicate real conditions. Analytical results of the acquisition failure probability align closely with the simulation results. Under the Taiji program’s parameter settings, the scan speed is set to 3.31 μrad/s, the track width to 0.87 μrad, and the integration time to 800ms. These parameters are optimized to minimize the mean acquisition time over multiple scans, resulting in a single link acquisition time of 223.77s. The analytical model can be used for the parameter design of inter-satellite laser link acquisition under weak light conditions.
A New Species in the Canthon indigaceus Species Group (Coleoptera: Scarabaeidae: Scarabaeinae) from the Mexican Pacific Coast
Authors: Rivera-Gasperín Sara Lariza , Escobar-Hernández Fernando , Arellano Lucrecia 
Published: February 2025

The Canthon indigaceus species group represents a Typical Neotropical distributional pattern with wide penetration into the Mexican Transition Zone. This group consists of three species: C. (C.) indigaceus LeConte; C. (C.) chiapas Robinson; and C. (C.) chevrolati Harold. In this study, a new species for the group is described, C. (C.) cuixmala, collected along the tropical region of the Pacific coast and the Balsas River basin. The taxonomic status of members of the group were evaluated by comparing morphological characteristics and their biogeographic distributions. An updated dichotomous key is provided to separate members of this species group.
A Candidate Ac3-S-LPS Vaccine Against S. flexneri 1b, 2a, 3a, 6, and Y Activates Long-Lived Systemic and Mucosal Immune Responses in Healthy Volunteers: Results of an Open-Label, Randomized 2 Clinical Trial
Authors: Ledov Vladimir A. , Romanenko Victor V. , Golovina Marina E. , Alkhazova Biana I. , Kovalchuk Alexander L. , Aparin Petr G. 
Published: February 2025

Objectives: Determination of reactogenicity and immunogenicity of a pentavalent candidate vaccine against S. flexneri 1b, 2a, 3a, 6, and Y (PLVF). Methods: The study involved 80 healthy adult volunteers aged 18–55 years. Groups were subcutaneously immunized twice at a 30-day interval with 62.5 μg/0.5 mL or 125 μg/0.5 mL of the vaccine. Results: During the entire 8-month period of post-vaccination observation, the vaccine was well tolerated, with no local or systemic reactions detected objectively. The results of laboratory studies demonstrated no effect on the main indicators of hemogram, biochemical blood test, or urinalysis. IgA, IgG, and IgM levels against LPS S. flexneri 1b, 2a, 3a, 6, and Y were examined before vaccination, a month after each vaccination, and 6 months after booster vaccination. One month after vaccination, IgA and IgG seroconversions were observed in 67.5–82.5% (depending on serotype) and 60–77.5% of volunteers, respectively. Booster immunization did not have a significant effect on vaccine immunogenicity. In two separate groups of 15 and 9 volunteers for mucosal sIgA, IgA, and IgG titer determination after immunization with a 125 μg vaccine dose, paired stool, and saliva samples were taken before and one month after vaccination. In 26.7–40% of volunteers, there was a 2-fold and higher increase in sIgA titer for the studied serotypes in the feces and in 66.7–88.9% in saliva. IgA and IgG 2-fold conversion rates were 26.7–53.3% and 33.3–46.7% in the feces, 33.3–77.9%, and 66.7–77.8% in saliva, respectively. Conclusions: the tolerability of PLVF and the pronounced humoral immune response allow us to proceed to the phase 3 clinical trial stage.
De-labelling erroneous penicillin allergy records in general practice: healthcare professionals’ experiences
Authors: Roleston Caity , Santillo Marta , Armitage Kelsey F , Porter Catherine E , Ahmed Shadia , Fielding Joanne , Wanat Marta , Butler Christopher C , Pavitt Sue , Sandoe Jonathan AT , Tonkin-Crine Sarah 
Published: February 2025

BackgroundPenicillin allergy (PenA) prevalence is approximately 6%, but fewer than 10% of these people are expected to be truly allergic. Consequently, a significant proportion of the population are prescribed alternative antibiotics with potential increased risk of acquiring multi-drug resistant bacteria and worse health outcomes. The ALABAMA trial aimed to determine if a penicillin allergy assessment pathway (PAAP) initiated in primary care, is effective in de-labelling erroneous records, improving antibiotic prescribing and patient outcomes.AimTo investigate healthcare professionals’ experiences of the ALABAMA trial.Design & settingQualitative study using semi-structured interviews in general practice in England.MethodSemi-structured interviews were conducted with healthcare professionals (including general practitioners, research nurses, pharmacists) who delivered the trial. Interviews explored their views about de-labelling incorrect PenA records, their role(s) in the trial, and, where relevant, their experience of prescribing following de-labelling.ResultsHealthcare professionals (n=18) believed many patients were incorrectly labelled PenA and were aware of the individual and public health risks this posed. However, GPs explained labels were rarely challenged in general practice because the perceived risks to patients and their professionalism were too great. The PAAP intervention, alongside the ‘protocolisation’ within the ALABAMA trial, was successful at mitigating these risks. Consequently, the trial was well-accepted and commended by healthcare professionals.ConclusionsGPs welcomed and accepted the PAAP as a means of correcting erroneous PenA records. There is great potential for PAAP to be supported in primary care if testing becomes more accessible.
SYSTEMATIC LITERATUR REVIEW: EQUITY CROWDFUNDING DALAM PERSPEKTIF INVESTOR
Authors: Sumayyah Sumayyah , Zahara Inna 
Published: February 2025

Bisnis equity crowdfunding juga berlandaskan asas kepercayaan antara pihak yang memberikan dana yakni investor dengan pihak yang mengelola dana pihak pelaku UMKM. Sehingga dari kasus diatas keamanan dan perlindungan pada investor rupanya tidak berbanding lurus dengan peluang bagi pelaku bisnis dalam memperoleh alternatif permodalan. Oleh karena itu, Investasi equity crowfunding juga dapat dikaitkan dengan teori agensi.Dalam penelitian ini metode kualitatif deskriptif yang diproksikan dengan literatur review. Peraturan OJK sudah memuat mengenai layanan pengaduan konsumen di sektor jasa keuangan. Regulasi ini mencakup Equity Crowdfunding sebagai subjek bisnis dan lembaga jasa keuangan. Namun, peraturan ini hanya memberikan fasilitas bagi konsumen yang telah mengalami kerugian akibat pelanggaran oleh subjek bisnis, sehingga pendekatan perlindungan yang ada bersifat represif. Sementara itu, dalam konteks penyelenggaraan equity crowfunding, yang masuk dalam sektor pasar modal, pendekatan perlindungan hukum yang lebih ditekankan adalah perlindungan preventif. Hal ini disebabkan oleh pentingnya kepercayaan investor dalam menempatkan investasi mereka di pasar modal.
Kinerja dan Profesionalisme Pegawai sebagai Kunci Kepuasaan Nasabah Bank Syariah Indonesia
Authors: Firdayetti Firdayetti , Rahma Syakila Kania 
Published: February 2025

Purpose: This study aims to identify the relationship between employee performance and professionalism and the level of customer satisfaction at Bank Syariah Indonesia (BSI), especially in the West Jakarta area.
Research Methodology: This type of research is quantitative using a correlational approach. Data collection techniques included questionnaires and data analysis tools using smartphones. Data analysis techniques include outer model tests consisting of convergent validity, descriptive validity, and internal consistency reliability, whereas inner model tests consist of determination coefficients, predictive relevance, goodness of fit, and hypothesis testing. The number of respondents in this research is 160 respondents.
Results: Employee performance and professionalism have a significant positive influence on customer satisfaction. Professionalism has proven to have a more dominant influence than employee performance.
Limitation: This study is limited to the West Jakarta area and only uses secondary data of 160 respondents consisting of 35 customers of KCP Jakarta Cengkareng, 8 customers of KCP Duri Kosambi, 6 customers of KCP Jakarta Joglo, 9 customers of KCP Jakarta Kalideres, 8 customers of KCP Jakarta Kedoya, 7 customers of KCP Jakarta Kelapa Dua, 8 customers of KCP Jakarta Kemanggisan, so the results may not fully reflect conditions in other areas or include other relevant variables in the Islamic banking industry.
Contribution: This study provides a practical contribution by highlighting the importance of improving employee competency and compliance with professional standards to improve customer satisfaction. Academically, this study adds to the literature on the influence of human resources on service quality in the Islamic banking sector.
Tren Pemilihan Metodologi Penelitian pada Skripsi Mahasiswa Program Studi Kedokteran Gigi Universitas Sriwijaya: Sebuah Tinjauan Naratif
Authors: Puspa Dewi Siti Rusdiana , Legiran Legiran 
Published: February 2025

Abstrak
Latar belakang: Pemilihan metodologi penelitian yang tepat sangat dibutuhkan dalam suatu penelitian. Keberagaman ini jenis metodologi penelitian mahasiswa ini belum diidentifikasi secara menyeluruh, sehingga belum diketahui arah penelitian yang telah dilakukan. Informasi mengenai trend pemilihan metodologi penelitian dapat dijadikan salah satu acuan untuk membuat kebijakan yang bisa meningkatkan kualitas akademik. Tujuan penelitian ini adalah untuk melakukan analisis terhadap tren pemilihan metodologi penelitian pada skripsi mahasiswa Program Studi Kedokteran Gigi FK Unsri. Metode : Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Penelitian dilakukan pada Program Studi Kedokteran Gigi FK Unsri dengan objek penelitian adalah dokumen skripsi mahasiswa selama 3 tahun terkahir. Data yang diambil dalam penelitian ini sebanyak 191 skripsi mahasiswa dengan rincian tahun 2021 sebanyak 59 skripsi, tahun 2022 sebanyak 73 skripsi, dan tahun 2023 sebanyak 59 skripsi. Hasil : Berdasarkan hasil analisis, maka didapat bahwa mahasiswa kedokteran gigi banyak mengambil jenis penelitian dengan metodologi analitik eksperimental, diikuti dengan studi deskriptif dan analisis observasional pada ketiga tahun terakhir. Tema yang dipilih adalah tema penelitian herbal yang mayoritas dilakukan secara in vitro, diikuti dengan penelitian material kedokteran gigi. Metode ini dipilih karena dapat memberikan hasil yang lebih mudah divalidasi, mudah direplikasi, lebih ekonomis, dan lebih fleksibel. Tema herbal dipilih karena tanaman herbal banyak digunakan oleh masyarakat dan belum pernah dilakukan pengujian sebelumnya. Kesimpulan : Tren pemilihan metodologi penelitian pada skripsi mahasiswa Prodi Kedokteran Gigi FK Unsri adalah analitik eksperimental, dengan tema penelitian herbal yang dilakukan secara in vitro.