bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart failure in Fabry disease revisited: application of current heart failure guidelines and recommendations
Authors: Rob Daniel , Marek Josef , Dostalova Gabriela , Linhart Ales 
Published: August 2022

AbstractAimsFabry disease (FD) is often associated with heart failure (HF). However, data on HF prevalence, prognosis, and applicability of echocardiographic criteria for HF diagnosis in FD remain uncertain.Methods and resultsWe evaluated patients with genetically proven FD for symptoms and natriuretic peptides indicating HF. We then analysed the diagnostic utility of the currently recommended European Society of Cardiology (ESC) echocardiographic criteria for HF diagnosis and their relationship to natriuretic peptides. Finally, we examined the association between HF and echocardiographic criteria with mortality and cardiovascular events during follow‐up. Of 116 patients with FD, 48 (41%) had symptomatic HF (mean age 58 ± 11 years, 62% male). HF with preserved ejection fraction (HF‐pEF) was diagnosed in 43 (91%) patients, representing the dominant phenotype. Left ventricular mass index (LVMi) had the highest diagnostic utility (sensitivity 71% and specificity 83%) for HF diagnosis in FD, followed by E/e′ > 9 (sensitivity 76% and specificity 78%) and global longitudinal strain (GLS) <16% (sensitivity 54% and specificity 88%). Log N‐terminal pro‐brain natriuretic peptide correlated significantly with LVMi (r = 0.60), E/e′ (r = 0.54), and GLS (r = 0.52) (all Ps < 0.001) but not with left ventricular ejection fraction (r = −0.034, P = 0.72). During follow‐up (mean 1208 ± 444 days), patients diagnosed with HF had a higher rate of all‐cause mortality and worsening HF (33% vs. 1.5%, P < 0.001). Abnormal LVMi, E/e′ > 9, and GLS < 16% were all associated with higher all‐cause mortality and worsening HF.ConclusionsThis study found a high prevalence of symptomatic HF in FD patients. HF‐pEF was the dominant phenotype. LVMi, E/e′, and GLS yielded the highest diagnostic utility for HF diagnosis and were significantly correlated with natriuretic peptides levels. Echocardiographic criteria proposed by current ESC HF guidelines apply to Fabry patients and predict cardiovascular events. At follow‐up, Fabry patients with HF diagnosis had high event rates and significantly worse prognosis than patients without HF.
The Systems Chemistry of Nucleic‐acid‐Peptide Networks
Authors: Kumar Bandela Anil , Sadihov‐Hanoch Hava , Cohen‐Luria Rivka , Gordon Christella , Blake Alexis , Poppitz George , Lynn David G. , Ashkenasy Gonen 
Published: August 2022

AbstractLiving cells use chemical building blocks (biopolymers) to form fascinatingly complex architectures, which in turn display multiple functions necessary for the cell life cycle. The mechanisms and order of events by which forerunners of these extant biopolymers formed on the early earth remains under intensive investigation. Prebiotic chemistry research has recently provided ample evidence that both peptide and nucleic‐acid (NA) precursors could be formed in a primordial environment through common synthetic routes. However, until recently, studies directed at the design of functional supramolecular structures have focused primarily on assemblies made of either peptides or NAs. The emerging discipline of Systems Chemistry now develops dynamic supramolecular interactions to capture the complex emergent properties of reaction networks. Accordingly, we review here recent work that reveals mutualistic nucleic acid/peptide co‐assembly, and approaches toward utility of these architectures as functional materials capable of substrate binding, catalysis, replication, and translation. Many of these new approaches to smart soft biomaterials and functional bio‐nanotechnology provide insight and extend our understanding of the possible origins of living systems.
ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF‐κB signaling pathway
Authors: Wang Zihan , Hu Jiancong , Chen Junxiong , Zhang Jingdan , Li Weiqian , Tian Yu , Liu Huanliang , Yang Xiangling 
Published: August 2022

AbstractBackgroundThe inhibitor of β‐catenin and T‐cell factor (ICAT) is a direct negative regulator of the canonical Wnt signaling pathway, which is an attractive therapeutic target for colorectal cancer (CRC). Accumulating evidence suggests that ICAT interacts with other proteins to exert additional functions, which are not yet fully elucidated.MethodsThe overexpression of ICAT of CRC cells was conducted by lentivirus infection and plasmids transfection and verified by quantitative real‐time reverse transcription‐polymerase chain reaction (real‐time RT‐PCR) and Western blotting. The effect of ICAT on the mobility of CRC cells was assessed by wound healing assay and transwell assay in vitro and lung metastasis in vivo. New candidate ICAT‐interacting proteins were explored and verified using the STRING database, silver staining, co‐immunoprecipitation mass spectrometry analysis (Co‐IP/MS), and immunofluorescence (IF) staining analysis.ResultInhibitor of β‐catenin and T‐cell factor overexpression promoted in vitro cell migration and invasion and tumor metastasis in vivo. Co‐IP/MS analysis and STRING database analyses revealed that junction plakoglobin (JUP), a homolog of β‐catenin, was involved in a novel protein interaction with ICAT. Furthermore, JUP downregulation impaired ICAT‐induced migration and invasion of CRC cells. In addition, ICAT overexpression activated the NF‐κB signaling pathway, which led to enhanced CRC cell migration and invasion.ConclusionInhibitor of β‐catenin and T‐cell factor promoted CRC cell migration and invasion by interacting with JUP and the NF‐κB signaling pathway. Thus, ICAT could be considered a protein diagnostic biomarker for predicting the metastatic ability of CRC.
Stressful life events among women living homeless in Nicaragua, a low‐income country
Authors: Vázquez José Juan , Berríos Alberto , Cala‐Montoya Caridad A. , Lenta Malena 
Published: August 2022

AbstractNicaragua is one of the lowest income countries in Latin America, where there is a shortage of data on women living homeless. This paper analyses the types, timing and perceived causality of stressful life events (SLE) suffered both during childhood and adolescence and throughout life by women living homeless (n = 30). A structured interview was used to collect the data. Findings showed that women living homeless in Nicaragua suffered a very high number of SLEs, and that these were extremely severe and from very early ages. Most of the SLEs took place before the women became homeless. The SLEs suffered by the women interviewed in Nicaragua were largely similar to those seen in women living homeless in other cultural contexts with higher incomes, although it should be noted that those interviewed in Nicaragua had suffered a higher number of SLE during their childhood and adolescence. The women interviewed mainly attributed finding themselves homeless to having suffered SLEs in the family environment. The suffering of multiple and severe SLEs, largely leading to living in socioeconomically disadvantaged situations, seem to present a significant vulnerability factor both for becoming homeless and remaining homeless over time.
Experience with a nurse‐driven genetic counseling pathway of Italian women with uninformative BRCA test result
Authors: Blondeaux Eva , Lambertini Matteo , Buzzatti Giulia , Bruzzone Carla , Baraga Marina , Pisani Roberta , Del Mastro Lucia , Pronzato Paolo , Varesco Liliana , Bonelli Luigina 
Published: August 2022

AbstractSeveral models of genetic counseling have been proposed to tackle the increasing volume of individuals requiring access to BRCA testing. Few data are available on patient experience and retention of information with nurse‐driven genetic counseling. We evaluated the experience and retention of information in women with an uninformative BRCA test result and who were not considered at high risk due to their personal/family history of cancer who underwent geneticist‐supervised nurse‐driven genetic counseling and who received their test result by phone. Women who received an uninformative BRCA test result between May 2017 and September 2019 were administered a questionnaire exploring experience with genetic counseling and retention of information provided. Of 366 eligible women, 299 (273 breast cancer patients and 26 women without breast cancer) completed the interview. Overall, 280 women (93.6%) positively valued their experience with genetic counseling and 287 (96.0%) considered it helpful with 57.5% of them feeling reassured for themselves and their family. Information on the clinical implications of the test result was correctly retained and women acted accordingly. Overall, 252 women (87.8%) accurately reported their test result as normal/negative. Only 67 (22.4%) recognized that despite a normal BRCA test result, a low probability of a hereditary syndrome remains. Most women showed a poor ability to estimate cancer risk in BRCA mutation carriers and in the general population. Geneticist‐supervised nurse‐driven genetic counseling process for women with uninformative BRCA test result is associated with a positive patient experience and an adequate retention of information concerning the management of their personal and familial cancer risk. The design and implementation of nurse‐driven genetic counseling models may contribute to efficient and timely access to BRCA genetic testing.
Constructing certain families of 3‐polytopal graphs
Authors: Maffucci Riccardo W. 
Published: August 2022

AbstractLet and be a 3‐polytopal graph such that for every , has at least one vertex of degree . We find the minimal vertex count for . We then describe an algorithm to construct the graphs . A dual statement may be formulated for faces of 3‐polytopes. The ideas behind the algorithm generalise readily to solve related problems. Moreover, given a 3‐polytope comprising a vertex of degree for all , fixed, we define an algorithm to output for a 3‐polytope comprising a vertex of degree , for all , and such that the initial is a subgraph of . The vertex count of is asymptotically optimal, in the sense that it matches the aforementioned minimal vertex count up to order of magnitude, as gets large. In fact, we only lose a small quantity on the coefficient of the second highest term, and this quantity may be taken as small as we please, with the tradeoff of first constructing an accordingly large auxiliary graph.
Interactive 3D touch and gesture capable holographic light field display with automatic registration between user and content
Authors: Sánchez Salazar Chavarría Iván Alexis , Shimomura Kyoka , Takeyama Saori , Yamaguchi Masahiro 
Published: August 2022

AbstractThis paper presents an interactive three‐dimensional (3D) touch and gesture user interface that utilizes a light‐field display and a 3D sensor. In contrast to conventional gesture interfaces, in which usually the image space and gesture space are separated, a user can directly interact with the 3D image in this interface system. To achieve this trait, the 3D registration between the sensor and display coordinate systems is necessary. In this study, we propose a method to automatically match the position of the reconstructed 3D image with the position of the hand of the user based on scattered light detection. The proposed calibration process is automatic and enables self‐calibration during practical operation without laborious measurement work. The method allows us to use the gesture detection capabilities of the leap motion controller to develop an interface where content and gesture positions match. We show some examples of 3D touch and gesture interactions in which the gesture position and the generated content match on a light field display.
Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
Authors: Raynor Eileen M. , Martin Hannah L. , Poehlein Emily , Lee Hui‐Jie , Lantos Paul 
Published: August 2022

AbstractObjectives/hypothesisThe objective of this study is to describe long‐term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV.Study typeClinical research study.DesignRetrospective cohort study.MethodsRetrospective chart review was performed for mothers seropositive to CMV. Mother–infant dyads (130) were identified between January 1, 2013 and January 1, 2017. Outcomes data was collected through June 1, 2020. Demographics, risk factors for hearing loss, evidence of CMV infection, other causes of hearing loss, need for speech therapy services, and results of all hearing tests were collected.ResultsAll 130 infants were asymptomatic and 5 were tested for congenital CMV. Five were negative for CMV and excluded from analyses. Of the remaining 125, only 1 had low‐viral avidity IgG antibodies. None had IgM antibodies. Four children (3.2%) had hearing loss at last audiogram and one child had delayed onset SNHL due to an enlarged vestibular aqueduct. Speech therapy for communication was required for 33 children (26.4%).ConclusionsKnowledge of maternal perinatal CMV status can allow for education about possible sequelae of cCMV, as well as trigger an alert for testing babies born to mothers with low‐viral avidity IgG during the first trimester, when the risk of vertical transmission is highest. Also, babies born to CMV positive mothers may be more at risk for communication delays necessitating intervention. Studies focusing on the impact of maternal CMV related to childhood communication deficits could elucidate any direct relationships.
Minor histocompatibility antigens HA‐8 and PANE1 in the TUNISIAN population
Authors: Said Rahma , Sellami Mohamed Hichem , Kaabi Houda , Hmida Slama 
Published: August 2022

AbstractBackgroundMinor histocompatibility antigens (mHAgs) are endogenous immunogenic peptides initially identified due to complications detected in several contexts of HLA geno‐identical hematopoietic stem cell transplantation (HSCT). In this study, we chose to examine the molecular polymorphism of the mHAgs HA‐8 and PANE1 in the Tunisian population.Material and MethodsThis study was conducted on 150 healthy and unrelated individuals. The DNA extraction and Sequence‐Specific Primers PCR (PCR‐SSP) methods were used for the molecular genotyping of the selected SNPs: PUM3 (rs2173904) and CENPM (rs5758511).ResultsOur results show that, 94% of Tunisians are carriers of the PANE1R allele (immunogenic variant of the PANE1 mHAg) and 68% of Tunisians are carriers of the HA‐8R allele (immunogenic variant of the HA‐8 mHAg). Furthermore, this study shows that about 5% of the Tunisians are carrier of the PANE1R antigen and its HLA molecule of presentation (the PANE1R/HLA‐A*0301 combination). However, only 2% of Tunisians are carrier of the HA‐8R/HLA‐A*0201 combination, that is, the HA8 immunogenic variant and its specific HLA molecule of presentation.ConclusionOur results are close to those reported in Caucasian, Asiatic, and African populations, this may be explained by the historical events experienced by Tunisia for millennia. These results could be used for further clinical and anthropological studies.
Neurocognitive functioning in children with sickle cell anemia and history of abnormal transcranial doppler ultrasonography
Authors: Longoria Jennifer N. , Wang Winfred , Kang Guolian , Gossett Jeffrey , Krull Kevin , King Allison A. , Raches Darcy , Schreiber Jane , Heitzer Andrew M. , Hankins Jane S. 
Published: August 2022

AbstractBackgroundTranscranial doppler (TCD) ultrasonography can be used to identify stroke risk in children with sickle cell anemia. Previous studies have reported mixed findings on neurocognitive outcomes in children with elevated TCD. This study examined associations between TCD velocity and neurocognitive outcomes in children and adolescents without prior history of stroke.ProcedureParticipants were selected from the Sickle Cell Clinical Research Intervention Program cohort. The highest recorded mean maximum TCD velocity was selected for analysis, along with participant's most recent data from serial neurocognitive surveillance.ResultsA total of 200 children with sickle cell anemia completed neurocognitive testing (109 males, 91 females; mean age 12.7 years [SD = 3.56]). Most participants were prescribed hydroxyurea (72%) at the time of neurocognitive testing and nearly 16% had a history of chronic transfusions prior to neurocognitive evaluation. Mean age at time of highest TCD value was 6.6 years (SD = 2.5) and 13.5% of screenings were abnormal (≥200 cm/s). Mean interval between TCD and most recent neurocognitive evaluation was 6.1 years (±3.5). There were no significant differences in the interval between TCD and neurocognitive testing across normal, conditional, and abnormal groups. Maximum TCD velocity was not significantly associated with neurocognitive outcomes in multivariate models.ConclusionsHistory of elevated TCD in the absence of overt stroke should not be considered a risk factor for poor neurocognitive outcomes in children and adolescents with sickle cell anemia on modern disease‐modifying therapy.
Proteomic characteristics of plasma and blood cells in natural aging rhesus monkeys
Authors: Wu Na , Xiao Fuchuan , Zhang Jing , Chi Yafei , Zhai Yanan , Chen Baian , Lu Jing 
Published: August 2022

AbstractAging has become a serious social issue that places a heavy burden on society. However, the underlying mechanisms of aging remain unclear. This study sought to understand the aging process as it may be affected by proteins in the blood, the most important functional system for material transportation in the body. We analyzed and compared the protein expression spectrums in the blood of old and young rhesus monkeys and found 257 proteins expressed differentially in plasma and 1183 proteins expressed differentially in blood cells. Through bioinformatics analysis, we found that the differentially‐expressed proteins in plasma were involved in signal pathways related to complement and coagulation cascades, pertussis, malaria, phagosome, and cholesterol metabolism, while the differentially‐expressed proteins in blood cells were involved in endocytosis, proteasome, ribosome, protein processing in the endoplasmic reticulum, and Parkinson's disease. We confirmed that the protein levels of complement C2 in plasma and actin‐related protein 2/3 complex subunit 2 (ARPC2) in blood cells obviously decreased, whereas the complement C3 and complement component 4 binding protein beta (C4BPB) significantly increased in plasma of old rhesus monkeys and C57BL/6 mice. Our results suggest that C2, C3, C4BPB, and ARPC2 can be used as target proteins for anti‐aging research.
The therapeutic effects of climbing: A systematic review and meta‐analysis
Authors: Gassner Lucia , Dabnichki Peter , Langer Agnes , Pokan Rochus , Zach Heidemarie , Ludwig Michaela , Santer Agnes 
Published: August 2022

AbstractObjectiveSeveral recent studies show a growing popularity of therapeutic climbing (TC) for patients with various conditions. This could be an attempt to fill the gap left by traditional exercises that do not always address physical, mental, and social well‐being. This review provides an overview of the physical, mental, and social effects and safety aspects of climbing for different indications.Literature SurveyA literature search was conducted on July 8, 2020 (update search August 26, 2021). We searched MEDLINE via Ovid, Embase, and PubMed and bibliographies of included studies, and we conducted a manual search.MethodologyTwo independent reviewers evaluated the quality of the studies using appropriate Risk of Bias (RoB) tools, and the level of evidence for each domain was graded. Study characteristics and effectiveness data for TC were extracted and synthesized. Meta‐analyses were conducted for the three dimensions (physical/mental/social health), using a random‐effects model.SynthesisA total of 112 publications were reviewed, and 22 full‐text articles were assessed regarding the eligibility criteria, of which 18 trials involving 568 patients were included. TC is safe and positively affects physical (e.g., fitness, motor control, movement velocity, dexterity, strength), mental (e.g., depressiveness, somatisation, psychoticism, emotion regulation, body perception, self‐esteem, fatigue), and social (e.g., social functioning, trust, communication, sense of responsibility) health for individuals with neurological, orthopedic, psychiatric, and pediatric ailments. The meta‐analysis showed a statistically significant improvement in the physical dimension favoring the climbing group. Improvements that were not statistically significant were found for the mental/social dimensions in the climbing group. The heterogeneity of data was moderate/high (social/mental dimension), and for the physical dimension, data were homogenous.ConclusionsThe studies investigating TC outline its positive effects in various patient groups. TC is a safe and effective treatment for improving physical/mental/social well‐being. This review is based on the best available evidence; however, significant gaps remain in providing sufficiently strong evidence.
Super‐twisting sliding mode trajectory tracking adaptive control of wheeled mobile robots with disturbance observer
Authors: Li Zeyu , Zhai Junyong 
Published: August 2022

AbstractThis article aims at the difficulties of wheeled mobile robots (WMR) system with wheeled slipping and control backlash in trajectory tracking. A novel sliding mode control strategy is proposed. For estimating the lumped disturbance, an adaptive sliding mode disturbance observer is constructed and achieves the finite‐time convergence of estimate error. For the purpose of accelerating the trajectory tracking, a novel arctangent terminal sliding mode surface is designed. To overcome the control chattering, a novel super‐twisting sliding mode controller is constructed which makes the control effect continuous and achieves finite‐time tracking of virtual reference velocities. The asymptotic convergence of trajectory tracking error is guaranteed by the Lyapunov stability theory. The simulation and comparison results of a WMR system demonstrate the validity of the proposed scheme for trajectory tracking.
Railways: Tracks, Trains, and Travellers
Authors: Fisher-Høyrem Stefan 
Published: August 2022

AbstractThe Victorian railway network of technologies and associated practices was a prime site of secularization. A secular time independent of motion was the condition of possibility underpinning railway travellers’ ability to negotiate timetables formally locating all spaces within the same temporal grid, or to engage in conducts allowing their bodies to be relatively at rest while in transit. The electric telegraph helped towards expanding this temporal grid on a national scale, enveloping the entire national (eventually imperial) territory as an increasingly temporally synchronized whole. In this way, and to the degree that it succeeded in moving human bodies without deterioration, the Victorian railway network mediated secular time.