bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Profit of a Land and the Purpose of a King: The Translation and Interpretation of Ecclesiastes 5:8
Authors: Rogland Max 
Published: January 2022

Abstract
The MT of Eccl 5:8 presents challenges of lexicography, grammar, and syntax, in addition to exegetical and text-critical difficulties. This article surveys some attempts to interpret Eccl 5:8 without resorting to textual emendation, and then proposes a new translation and analysis of the MT in its exegetical context. Ecclesiastes 5:8 delineates the benefit of a land or country as being found “in the whole” rather than in one of its component parts. While one will observe governmental corruption in an individual “province” (v. 7), Qoheleth observes that a national governing structure, embodied in a king, brings the benefit of political stability, which ultimately enables an agrarian society to flourish.
Scholarly Values, Methods, and Evidence in the Academic Study of Religion
Authors: Taves Ann , Wildman Wesley J. , Shults F. LeRon , Paloutzian Raymond F. 
Published: January 2022

Abstract
The Values in Scholarship on Religion (VISOR) project collected data on the preferred methods and values of scholars in the academic study of religion. This dataset supports comparisons between members of the American Academy of Religion (AAR) and partner organizations, such as the North American Association for the Study of Religion (NAASR), as well as members of the Society for the Scientific Study of Religion (SSSR). The AAR-partner sample differs from the SSSR sample in consistently preferring humanities over empirical approaches. Both samples were modestly aligned with the secular academy in rejecting theological claims as evidence. The subgroups within the AAR-partner sample that were affiliated with the International Association for the History of Religions (IAHR) were the most firmly committed to secular approaches and evidence. These findings indicate the range of perspectives currently present in the big-tent AAR, which deliberately embraces theological scholarship as well as secular religious studies research.
Garpenbergite, Mn6□As5+Sb5+O10(OH)2, a new mineral related to manganostibite, from the Garpenberg Zn–Pb–Ag deposit, Sweden
Authors: Holtstam Dan , Bindi Luca , Förster Hans-Jürgen , Karlsson Andreas , Gatedal Kjell 
Published: January 2022

AbstractGarpenbergite is a new mineral (IMA2020-099) from the Garpenberg Norra mine, Hedemora, Dalarna, Sweden. It occurs with carlfrancisite and minor stibarsen, paradocrasite and filipstadite in a fractured skarn matrix of granular jacobsite, alleghanyite, kutnohorite and dolomite. Crystals are short-prismatic, up to 1.5 mm in length. They have a blackish to greyish brown colour, and are lustrous semi-opaque, with brown streak. Garpenbergite is brittle, with an uneven to subconchoidal fracture. Cleavage is distinct on {010}. Hardness ≈ 5 (Mohs) and VHN100 = 650(40). Dcalc = 4.47(1) g⋅cm−3, overall ncalc = 1.85. Maximum specular reflectance values (%) obtained are 9.2 (470 nm), 9.1 (546 nm), 9.0 (589 nm) and 8.9 (650 nm). The empirical chemical formula of garpenbergite, based on electron microprobe data, is (Mn2+3.97Mg1.48Mn3+0.26Zn0.29)Σ6.00(As0.89Fe3+0.04Mn3+0.06Si0.01)Σ1.00(Sb0.98Fe0.02)Σ1O10[(OH)1.99Cl0.01]Σ2.00. The five strongest Bragg peaks in the powder X-ray diffraction pattern [d, Å (I, %) (hkl)] are 3.05 (30) (002), 2.665 (100) (161), 2.616 (40) (301), 2.586 (25) (251) and 1.545 (45) (462). The orthorhombic unit-cell dimensions (in Å) are a = 8.6790(9), b = 18.9057(19) and c = 6.1066(6), with V = 1001.99(18) Å3 for Z = 4. The crystal structure was refined from single-crystal X-ray diffraction data in the space-group Ibmm to R1 = 3.7% for 957 reflections. Garpenbergite, ideally Mn6As5+Sb5+O10(OH)2, is isostructural with manganostibite, Mn7AsSbO12, but possesses a cation vacancy (□) at an octahedrally coordinated structural site; the two minerals are thus related by the exchange Mn2+ + 2O2– → □ + 2(OH)–. The presence of hydroxyl groups is supported by vibration bands at 3647 and 3622 cm−1 in the Raman spectrum of garpenbergite and by bond-valence considerations.
Neural transcriptomic signature of chronic wasting disease in white-tailed deer
Authors: O’Hara Eóin , Herbst Allen , Kommadath Arun , Aiken Judd M. , McKenzie Debbie , Goodarzi Negin , Skinner Pamela , Stothard Paul 
Published: January 2022

Abstract
Background
The increasing prevalence and expanding geographical range of the chronic wasting disease (CWD) panzootic in cervids is threatening human, animal, environmental and economic health. The pathogenesis of CWD in cervids is, however, not well understood. We used RNA sequencing (RNA-seq) to compare the brain transcriptome from white-tailed deer (WTD; Odocoileus virginianus) clinically affected with CWD (n = 3) to WTD that tested negative (n = 8) for CWD. In addition, one preclinical CWD+ brain sample was analyzed by RNA-seq.

Results
We found 255 genes that were significantly deregulated by CWD, 197 of which were upregulated. There was a high degree of overlap in differentially expressed genes (DEGs) identified when using either/both the reference genome assembly of WTD for mapping sequenced reads to or the better characterized genome assembly of a closely related model species, Bos taurus. Quantitative PCR of a subset of the DEGs confirmed the RNA-seq data. Gene ontology term enrichment analysis found a majority of genes involved in immune activation, consistent with the neuroinflammatory pathogenesis of prion diseases. A metagenomic analysis of the RNA-seq data was conducted to look for the presence of spiroplasma and other bacteria in CWD infected deer brain tissue.

Conclusions
The gene expression changes identified highlight the role of innate immunity in prion infection, potential disease associated biomarkers and potential targets for therapeutic agents. An association between CWD and spiroplasma infection was not found.
Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial
Authors: Ibrahim Mohamed , Elnabtity Ali M. , Hegab Ahmed , Alnujaidi Omar A. , El Sanea Osama 
Published: January 2022

Abstract
Background
It is debatable whether opioid-free anaesthesia (OFA) is better suited than multimodal analgesia (MMA) to achieve the goals of enhanced recovery after surgery (ERAS) in patients undergoing laparoscopic sleeve gastrectomy.

Methods
In all patients, anaesthesia was conducted with an i.v. induction with propofol (2 mg. kg-1), myorelaxation with cisatracurium (0.15 mg.kg-1), in addition to an ultrasound-guided bilateral oblique subcostal transverse abdominis plane block. In addition, patients in the OFA group (n = 51) received i.v. dexmedetomidine 0.1 μg.kg-1 and ketamine (0.5 mg. kg-1) at induction, then dexmedetomidine 0.5 μg. kg-1.h-1, ketamine 0.5 mg.kg-1.h-1, and lidocaine 1 mg. kg-1.h-1 for maintenance, while patients in the MMA group (n = 52) had only i.v. fentanyl (1 μg. kg-1) at induction. The primary outcome was the quality of recovery assessed by QoR-40, at the 6th and the 24th postoperative hour. Secondary outcomes were postoperative opioid consumption, time to ambulate, time to tolerate oral fluid, and time to readiness for discharge.

Results
At the 6th hour, the QoR-40 was higher in the OFA than in the MMA group (respective median [IQR] values: 180 [173–195] vs. 185 [173–191], p < 0.0001), but no longer difference was found at the 24th hour (median values = 191 in both groups). OFA also significantly reduced postoperative pain and morphine consumption (20 mg [1–21] vs. 10 mg [1–11], p = 0.005), as well as time to oral fluid tolerance (238 [151–346] vs. 175 min [98–275], p = 0.022), and readiness for discharge (505 [439–626] vs. 444 min [356–529], p = 0.001), but did not influence time to ambulate.

Conclusion
While regional anaesthesia achieved most of the intraoperative analgesia, avoiding intraoperative opioids with the help of this OFA protocol was able to improve several sensible parameters of postoperative functional recovery, thus improving our knowledge on the OFA effects.

Clinical trial number
Registration number NCT04285255.
Stability of context in sport and exercise across educational transitions in adolescence: hello work, goodbye sport club?
Authors: Gut Vanessa , Schmid Julia , Imbach Lars , Conzelmann Achim 
Published: January 2022

Abstract
Background
The present study firstly aimed to identify context patterns in sport and exercise among adolescents at lower and upper secondary education. The organisational, social and competitive contexts of leisure-time sport and exercise were included as pattern indicators. The second aim was to examine the stability of these patterns across educational transition. The last aim was to investigate whether a subjective evaluation of the transition influences whether people stay in the same pattern across time.

Methods
One-year longitudinal data of 392 adolescents were analysed.

Results
Both before and after the educational transition, four context patterns were identified: the traditional competitive club athletes with friends, the self-organised individualists, the non-club-organised sportspersons and the mostly inactives. More than half of the individuals stayed in the same pattern across time. When individuals changed pattern, their change was most often from the self-organised individualists and the non-club-organised to the mostly inactives. A subjective evaluation of the transition influenced the stability of only the traditional competitive club athletes with friends. The chance of these people staying in the same pattern decreased with increased transitional stress.

Conclusions
Knowledge about the stability and change of context patterns can be used to make recommendations for policy strategies and to develop more individually-tailored promotion programs.
Impact of Dutch COVID-19 restrictive policy measures on physical activity behavior and identification of correlates of physical activity changes: a cohort study
Authors: Schoofs Merle C. A. , Bakker Esmée A. , de Vries Femke , Hartman Yvonne A. W. , Spoelder Marcia , Thijssen Dick H. J. , Eijsvogels Thijs M. H. , Buffart Laurien M. , Hopman Maria T. E. 
Published: January 2022

Abstract
Background
Identification of characteristics of individuals that are related to decreases in physical activity (PA) levels during lockdown is needed to develop targeted-interventions. This study aims to evaluate changes in domain-specific (i.e. leisure time, transportation, occupational, and household) and total PA due to the Dutch COVID-19 lockdown, which started on March 15 2020. Furthermore, we aim to identify demographic, health-related, and psychological correlates of these changes.

Methods
Individuals who participated in the Nijmegen Exercise Study during 2017-2019 were invited to this study, which was conducted between April 16 and May 12 2020. Participant characteristics (i.e. age, sex, body mass index (BMI), marital status, education, household composition, and occupation status), living environment (i.e. housing type and degree of urbanization), psychological characteristics (i.e. resilience, outcome expectations, vitality, and mental health), and medical history were collected via an online questionnaire. Short Questionnaire to Assess Health-enhancing physical activity was used to assess PA behavior before and during lockdown. Wilcoxon signed-rank test was used to compare PA levels, in metabolic equivalent of task (MET)-minutes per week (min/wk), before and during lockdown. Multivariable linear regression analyses were performed to examine correlates of PA changes.

Results
4033 participants (57% male; 59 ± 13 years) were included. PA decreased significantly during lockdown with mean ± SD changes of 393 ± 2735 MET-min/wk for total, 133 ± 785 MET-min/wk for transportation, 137 ± 1469 MET-min/wk for occupation, and 136 ± 1942 MET-min/wk for leisure time PA. Household PA did not change significantly. Unemployment, COVID-19-related occupational changes, higher BMI, and living in an apartment or semi-detached/terraced house were significantly related to larger decreases in total and domain-specific PA. Higher vitality was related to smaller decreases in total and domain-specific PA. Higher age was significantly associated with a larger decrease in leisure time PA. Lower education was associated with smaller decreases in transportation and occupational PA compared to higher education.

Conclusion
PA levels significantly reduced during lockdown compared to before lockdown. Declines were observed during transportation and occupation, but were not compensated by an increase in leisure time PA. We identified subgroups that were more susceptible to reductions in domain-specific or total PA levels and should therefore be encouraged to increase their PA levels during lockdown.
Trends in the development process of clinical practice guidelines: a questionnaire survey for the guideline development groups in Japan
Authors: Hatakeyama Yosuke , Seto Kanako , Hirata Koki , Onishi Ryo , Matsumoto Kunichika , Hasegawa Tomonori 
Published: January 2022

Abstract
Background
Clinical practice guidelines (CPGs) are representative methods for promoting healthcare standardization and improving its quality. Previous studies on the CPG (published by 2006) development process in Japan reported that the involvement of experts and patients, efficient evidence collection and appraisal, and paucity of evidence on Japanese patients should be improved for the efficient CPG development. This study aimed to clarify the trends of CPG development process in Japan, focusing on the involvement of experts and patients, efficient evidence collection and appraisal, and paucity of Japanese evidence.

Methods
A cross-sectional questionnaire survey was conducted for CPG development groups to collect information on the development activities of the CPGs published from 2012 to 2019. These CPGs were identified from the Japanese guideline clearinghouse. The questionnaire included the questions on composing the group, securing funding sources, collecting and appraising the research evidence, and the difficulties in the CPG development process. The questionnaires were distributed to the chairpersons of the CPG development groups through postal mail from November 2020 to January 2021. Combining the data from the current survey with those of previous studies reporting the development process of CPGs published by 2011, we analyzed the trend in the CPG development process.

Results
Of the total 265 CPGs included in the analysis, 164 (response rate: 41.4%) were from the current survey and 101 (response rate: 44.5%) were from previous studies. Among these, 40 (15.1%) were published by 2005, 47 (17.7%) in 2006–2010, 77 (29.1%) in 2011–2015, and 101 (38.1%) in 2016–2019. The proportion of CPGs involving methodologists did not increase through the publication periods. The proportion of CPGs involving patients almost doubled from the first period (15.9%) to the fourth period (32.4%). The yield rates of the articles did not change through the publication periods. The difficulty in “Coping with the paucity of Japanese evidence” has been improving consistently (69.2% in the first period to 37.4% in the fourth period).

Conclusions
Our results suggest the need for methodological improvement in the efficient collection and appraisal of evidence and in the system assigning experts to the CPG development groups.
Postbariatric EArly discharge Controlled by Healthdot (PEACH) trial: study protocol for a preference-based randomized trial
Authors: Scheerhoorn Jai , van Ede Lisa , Luyer Misha D. P. , Buise Marc P. , Bouwman R. Arthur , Nienhuijs Simon W. 
Published: January 2022

Abstract
Introduction
Performing bariatric surgery in a daycare setting has a potential reduction in hospital costs and increase in patients’ satisfaction. Although the feasibility and safety of such care pathway has already been proven, its implementation is hampered by concerns about timely detection of short-term complications. This study is designed to evaluate a combined outcome measurement in outpatient bariatric surgery supplemented by a novel wireless remote monitoring system versus current standard of care.

Methods and analysis
A total of 200 patients with multidisciplinary team approval for primary bariatric surgery will be assigned based on their preference to one of two postoperative trajectories: (1) standard of in-hospital care with discharge on the first postoperative day or (2) same day discharge with ongoing telemonitoring up to 7 days after surgery. The device (Healthdot R Philips) transfers heart rate, respiration rate, activity, and body posture of the patient continuously by LoRaWan network to our hospital’s dashboard (Philips Guardian). The primary outcome is a composite outcome measure within 30 days postoperative based on mortality, mild and severe complications, readmission, and prolonged length-of-stay. Secondary outcomes include patients’ satisfaction and data handling dimensions.

Trial registration
ClinicalTrials.govNCT04754893, Registered on 12 February 2021.
Effect of perioperative cognitive behavioural therapy on chronic post-surgical pain among breast cancer patients with high pain catastrophising characteristics: protocol for a double-blinded randomised controlled trial
Authors: Moorthy Aneurin , Lowry Damien , Edgley Carla , Casey Maire-Brid , Buggy Donal 
Published: January 2022

Abstract
Background
Surgery is regarded as the primary treatment for breast cancer. Chronic post-surgical pain (CPSP) is a recognised complication after breast cancer surgery, and it is estimated to affect 20–30% of women. Pain catastrophizing has emerged as one of the most influential psychological variables associated with CPSP.

Methods
This trial will be a single-centre, prospective, double-blinded, superiority, randomised controlled trial (RCT). Patients scheduled for elective breast cancer surgery (wide local excision or mastectomy with or without axillary lymph node dissection) will be screened preoperatively for high pain catastrophising. Patients with high pain catastrophising, defined as a score of ≥ 24 on the Pain Catastrophising Scale will be deemed eligible for inclusion in the study. Participants will be randomly assigned to receive either a cognitive behavioural therapy or an educational mindfulness based programme during their perioperative period. The primary outcome is the Brief Pain Inventory short form average pain severity score at 3 months postoperatively. Secondary outcomes include patient-reported quality of recovery at days 1–2 after surgery, levels of pain catastrophising, reported depressed mood and anxiety.

Discussion
To the best of our knowledge, this protocol describes the first RCT which directly examines the effect of perioperative cognitive behavioural therapy on CPSP among breast cancer patients with high pain catastrophising characteristics. The outcomes of this trial may have significant implications for these patients because perioperative cognitive behavioural therapy has the potential to become an important perioperative intervention to complement patient management.

Trial registration
ClinicalTrials.govNCT04924010. Registered on 11 June 2021. All item from the World Health Organisation Trial Registration Data set have been included.
Transradial peripheral vascular intervention using Fowler’s position and Terumo R2P system for patients with heart failure: two case reports
Authors: Nakamura Akihiro , Sato Kenjiro , Endo Hideaki 
Published: January 2022

Abstract
Background
Positioning a patient on the catheterization table is important for proper cardiac or respiratory function during peripheral vascular interventions. Fowler’s position, where the patient’s head is a 45° angle, is more effective in reducing venous blood volume returning to the heart from the periphery compared with the supine position. The Terumo R2P system has been developed for transradial peripheral vascular interventions.

Case presentation
Two patients with heart failure (a 75-year-old Japanese female and a 74-year-old Japanese male) underwent lower-extremity peripheral vascular interventions in Fowler’s position to prevent worsening heart failure. Because their head position was opposite the C-arm of the X-ray machine, the left radial artery was selected as the access site. The Terumo R2P system was used for transradial peripheral vascular intervention. We successfully treated superficial artery diseases with long shaft balloons and rapid-exchange Terumo R2P Misago stents.

Conclusions
Although lower-extremity peripheral vascular intervention using Fowler’s position and the Terumo R2P system has several limitations, including device availability and technical complexity, it may be effective for particular patients who have higher risk of worsening heart failure in the supine position.
High Power Sugar Fuel Cells Using PEDOT*PSS, CNT and PtRu Composite Anode
Authors: Kaneto Keiichi , Uto Sadahito 
Published: January 2022

Abstract
Output characteristics of sugars/KOH fuel cells using PEDOT*PSS, CNT, and PtRu composite (anode)/cellophane/Pt (cathode)/air have been studied. The maximum power density of glucose demonstrated 60 mWcm−2, being the best in the world. The relative outputs were 1, 0.37, 0.51, 0.42, and 0.006 for glucose, fructose, lactose, maltose, and sucrose, respectively, depending on the reducibility of sugars. The hydrolysis of sucrose with acids resulted in the enhancement of output. The coulombic and energetic conversion efficiencies are discussed comparing experimental and theoretical estimations.
Hyperosmolar Therapy for Diabetic Hyperosmolar Ketoacidosis
Authors: Heldeweg Micah LA , Drossaers Joris R , Berend Kenrick 
Published: January 2022

Hyperglycaemic hyperosmolar state (HHS) and diabetic ketoacidosis (DKA) features can occur simultaneously in 27% of diabetic emergencies and have a two-fold increased risk of death. Despite the high prevalence of this combination, recommended treatments from leading guidelines may not be compatible with the clinical picture. A 36-year-old man presented with explicit concurrent HHS and DKA. The recommended treatment with simultaneous insulin and volume repletion was followed but resulted in an excessively rapid decline in serum osmolarity. Hyperosmolar therapy (NaCl 3%) was initiated to mitigate the risk of potentially fatal cerebral osmotic shifts. The concomitant presence of DKA and HHS leads to a treatment dilemma with a high risk of excessive osmolarity shifts. More evidence is needed, but it is reasonable to initiate tailored treatment to avoid osmolarity reduction rates exceeding the hypernatraemia-based limit of 24 mOsm/l/day. Hyperosmolar therapy can be considered but requires frequent monitoring of electrolytes and osmolarity.