bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the digital portfolio of competencies in the general system for assessing the quality of learning outcomes of students of the university
Authors: Байкина Е.А. 
Published: October 2022

Рассмотрено понятие «цифровое портфолио компетенций». Представлен анализ итогов интеграции в учебный процесс вуза данного инструмента комплексной системы оценки результатов обучения студентов. Выявлены возможности цифрового портфолио компетенций как структурного элемента электронного портфолио обучающегося университета, механизма сбора, фиксации оценочных данных успеваемости для осуществления анализа полученных сведений и принятия управленческих решений. Сделан вывод об эффективности его использования в качестве инструмента непрерывного и динамичного процесса «документирования компетентности» обучающихся, создания компетентностного профиля студента в процессе или по итогам освоения им образовательной программы.
The article discusses the concept of “digital portfolio of competencies”. The analysis of the results of the integration into the educational process of the university of this tool of the integrated system of evaluation of the results of training of university students is presented. The possibilities of a digital portfolio of competencies as a structural element of an electronic portfolio of a university student, a mechanism for collecting and fixing evaluation data of student performance for analyzing the information received and making managerial decisions are revealed. The conclusion is made about the effectiveness of its use as a tool for a continuous and dynamic process of “documenting the competence” of university students, creating a competence profile of a student in the process or following the results of mastering an educational program.
The role of the word superiority effect in the productivity of verbal information recognition
Authors: Барченкова Л.В. , Шукурян Г.А. 
Published: October 2022

Описывается экспериментальное исследование, проведенное с целью изучения взаимодействия внимания и рабочей памяти при решении познавательной задачи, связанной с визуальным поиском и обработкой вербальной информации. Показано, что в условиях решения познавательной задачи слова воспринимаются автоматически, без участия сфокусированного объектного внимания, сохраняются в рабочей памяти на короткий промежуток времени без семантической обработки в виде пространственноорганизованного образа. Сделан вывод о том, что поиск вербальной информации не происходит продуктивнее за счет эффекта превосходства слова.
The article describes an experimental study conducted to study the interaction of attention and working memory in solving a cognitive task related to visual search and the verbal information processing. As a result of an experimental study, it was revealed that in the conditions of solving a cognitive task, words are perceived automatically, without the participation of focused object attention, and are stored in working memory for a short period of time in the form of a spatially organized image without semantic processing. It was concluded that the search for verbal information is not more productive due to the word superiority effect.
LINGUISTIC ORIGINALITY OF AMERICAN RAP COMPOSITIONS (ON THE EXAMPLE OF MACHINE GUN KELLY AND NF)
Authors: Borisova Inna Vladimirovna 
Published: October 2022

Aim. To reveal the phonetic, lexical, phraseological and syntactic peculiarities of the modern American rappers’ compositions and to determine the most frequent stylistic devices used by the performers.Methodology. The author has analyzed 15 rap compositions created by the American rappers Machine Gun Kelly and NF. The following methods were applied: continuous sampling method, descriptive-analytical method, method of statistical analysis and data interpretation, contextual and discursive analyses.Result. Having studied the factual material, the author found out that the greatest stylistic expressiveness of rap texts was achieved by using the following tropes: allusion, comparison, metaphor, periphrasis.Research implications. The modern material of rap discourse, which was not previously subjected to linguo-stylistic analysis, has been investigated. The originality of modern rappers’ texts has been revealed. It leads to understanding of how the strategic mechanisms, through which the performers influence their audience, are actualized. And this understanding enables listeners to perceive their idols’ creative work more adequately.
Análisis de las condiciones de competencia en el mercado de producción del oxígeno medicinal peruano en el contexto de la emergencia sanitaria y políticas públicas pendientes
Authors: Huamán Pérez Rocío , Antayhua López Oscar 
Published: October 2022

La Constitución Política del Perú en su artículo 61 regula el deber del Estado de facilitar y vigilar la libre competencia, combatiendo aquellas prácticas que la limiten y el ejercicio abusivo de posiciones monopólicas o dominantes. Sin embargo, no en todos los mercados se presentan condiciones de competencia perfecta, como en el caso del mercado de producción de oxígeno medicinal en el Perú, que se caracteriza por ser oligopólico, en específico un duopolio. Esta situación lleva a reflexionar sobre el rol del Estado en materia económica.
En el presente artículo, los autores analizan las características del mercado del oxígeno en Perú, con especial énfasis en la producción del oxígeno, los proveedores existentes y las barreras de entrada al mercado; asimismo, se evalúa la pertinencia y necesidad de las políticas dispuestas por el Estado a fin de afrontar la crisis sanitaria y permitir una distribución del oxígeno medicinal que pueda satisfacer la demanda de la población.
El desarrollo urbano sostenible en el bicentenario del Perú independiente: un asunto prioritario en la agenda política 2021-2026
Authors: Villalobos Villalobos Vicente Brayan 
Published: October 2022

El crecimiento desordenado y espontáneo de las ciudades y centros poblados es una característica del urbanismo peruano que resulta imposible de negar. En ese orden de ideas, el déficit habitacional y la ocupación informal del suelo, el menoscabo del medioambiente y el deterioro del patrimonio cultural de la nación, son problemáticas que exigen atención prioritaria.
En el presente artículo, el autor tiene como objetivo exponer la ineficiente planificación del Estado peruano en el desarrollo urbano a partir de los tres ejes problemáticos antes mencionados. En esa misma línea, sostiene que un factor clave en estos problemas ha sido la incoherencia normativa; por ello desarrolla los principales antecedentes históricos de la legislación urbanística peruana, a fin de demostrar que la desarticulación estatal en la gestión del uso del suelo es una característica del urbanismo nacional. Por último, aborda las razones por las que considera que la promulgación de la reciente Ley de Desarrollo Urbano Sostenible es el inicio de una seria planificación urbana en el Perú.
Particle Swarm Optimization Setup for Hyperparameter Selection in Support Vector Machines
Authors: Restrepo-Uribe Juan , Sepulveda-Suescun Juan , Orrego-Metaute Diana , Urda-Benitez Robert , Escobar Juan Murillo 
Published: October 2022

Abstract
Selecting hyperparameters for support vector machines is an optimization task that affects their classification performance. In particular, particle swarm optimization has been successfully applied for this purpose; however, the literature in the field has not addressed the effect of the population topology and the method for handling constraints in the search space. In this paper, we assessed two population types (von Neumann and fully connected) and four methods for handling constraints in the search space (penalization, dynamic penalization, reflect, and border), for a total of eight different PSO setups. These PSO setups helped us to optimize an SVM using a radial basis function kernel, which means that two hyperparameters were selected: cost parameter (C) and kernel width (γ). We conducted the experiments over 10 benchmark classification problems and for atrial fibrillation detection. Our findings suggest that using a von Neumann population together with the reflect method provides the SVM with the best classification capabilities and shortest execution time.
Predictors of Research Subject retention - Repetitive non-adherence or socioeconomic factors: Insights from a urological clinical trial
Authors: Wheeler Allison J , GARG HARSHIT , KAUSHIK DHARAM , Mansour Ahmed , PRUTHI DEEPAK , LISS MICHAEL A 
Published: October 2022

Abstract
Background:
To investigate various patient level variables, specifically socioeconomic status, as risk factors for withdrawal in a recently completed clinical study. We specifically investigate a recent study in men on adherence to an observational prostate cancer imaging and biomarkers study.
Methods:
We performed a retrospective study to investigate risk factors for withdrawal in a prostate cancer imaging study that enrolled men on active surveillance from January 2016 to June 2019. For each subject, we assessed their retention status and collected demographic data. We compared values between the two retention groups using T-test, Chi-Squared, and logistic regression.
Results:
Out of 273 men screened, 123 men were enrolled and included in the results of this study. Of those, 106 (86%) were retained in the study and 17 (14%) were withdrawn. While we found no significant relationship between low socioeconomic status and retention, we did find that the number of non-adherences was a significant factor in withdrawal from the study (OR 2.5, 95% CI 3.5–40.5, p < 0.001).
Conclusions:
Expanding diverse inclusion and limiting withdrawal with real-time non-adherence monitoring will lead to more efficient clinical research and greater generalizability of results.
Clinical Outcomes of Octogenarian Patients with Upper Gastrointestinal Bleeding
Authors: İNAN OSMAN , ACEHAN MUHAMMED FATİH , ŞAHİNER ENES SEYDA , ASLAN MERYEM , ALTIPARMAK EMİN , ATES İHSAN 
Published: October 2022

Abstract
Background: This study aimed to reveal whether there is any difference in clinical outcome between the octogenarian (>80 years old) and non-octogenarian patients in the geriatric patient group (>65 years old) with acute upper gastrointestinal bleeding.
Methods: Patients aged 65 and over who were admitted with non-variceal upper gastrointestinal system bleeding included in the study. Patients in the study were divided into 2 groups, those aged 65-80 years and those over 80 years of age. Groups were compared in terms of laboratory findings, endoscopy findings, and serious clinical outcome.
Results: The number of patients included in the study was 263 and their mean age was 78.25 ± 8.20 years. Comorbidity was present in 97.4% of the patients and in both groups the most common comorbid disease was hypertension. 28.5% of the patients were taking anticoagulants, 39.9% were taking antiplatelet drugs, and 18.6% were taking non-steroidal anti-inflammatory drugs. The median hospital stay of the patients was 5 days. In-hospital mortality was 5 (4.4%) and 6 (4.0%) and rebleeding was seen in 10 (8.8%) and 13 (8.7%) patients in the octogenarian and non-octogenarian groups, respectively. The frequency of patients who stayed in the hospital longer than 21 days was significantly higher in the octogenarian group compared to the other group (p=0.011).
Conclusion: There was no significant difference in terms of in-hospital mortality, re-bleeding, need for intensive care, need for endoscopic intervention or hospital stay, but the frequency of prolonged hospital stay was significantly higher in the octogenarian group.
Sex-based differences in the lipidomic profile of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication
Authors: Perpiñá-Clérigues Carla , Català-Senent José F. , Mellado Susana , Ibáñez Francesc , Costa Pilar , Marcos Miguel , Guerri Consuelo , García-García Francisco , Pascual Maria 
Published: October 2022

Abstract

Background Lipids represent essential components of extracellular vesicles (EVs), playing structural and regulatory functions during EV biogenesis, release, targeting, and cell uptake. Importantly, lipidic dysregulation has been linked to several disorders, including metabolic syndrome, inflammation, and neurological dysfunction. Our recent results demonstrated the involvement of plasma EV microRNAs as possible amplifiers and biomarkers of neuroinflammation and brain damage induced by ethanol intoxication during adolescence. Considering the possible role of EV lipids as regulatory molecules and biomarkers, we evaluated how acute ethanol intoxication differently affected the lipid composition of plasma EVs in male and female adolescents and explored the participation of the immune response. Methods Plasma EVs from humans, WT mice, and TLR4-KO mice were extracted. After the EVs lipids extraction and data acquisition by mass spectrometry, preprocessing and exploratory analyses were conducted. Experimental groups (ethanol and control groups of females and males) were compared from differential abundance analysis. Annotation of the lipids in their corresponding classes and a lipid set enrichment analysis were carried out to evaluate the biological function. Results We demonstrate for the first time that acute ethanol intoxication induces a higher enrichment of specific EV lipid species in human female adolescents (e.g., PA, LPC, unsaturated FA and FAHFA) than in males (e.g., PI). These lipid species participate in the formation, release, and uptake of EVs and the activation of the immune response. All data and results generated have been made openly available on a web-based platform (http://bioinfo.cipf.es/sal). Conclusions Our results suggest that female adolescents who binge drink alcohol also display increased levels of EV biogenesis and neuroinflammatory spread than males. Our findings also support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation during adolescence.
Facile preparation of graphite nanosheets with excellent adsorption property
Authors: Cao Kesheng , Tian Zhengshan , Zhang Xunyou , Wang Yabo , Zhu Qiuxiang 
Published: October 2022

Abstract
Graphene and its derivative (graphene oxide, GO) have lots of important functional applications in various fields. At present, the improved Hummers’ methods are the most important preparation methods used to prepare GO nanosheets in scientific research and industrial preparation. Although many improvement measures of the Hummers’ method have been performed, and some problems still need to be solved. Herein, we develop a facile and green method to prepare nanosheets by exfoliating graphite powders in a dilute sulfuric acid (H2SO4) aqueous solution with hydrogen peroxide (H2O2) as oxidant, and subsequent ultrasonic treatment. The characterization results confirm that graphite nanosheets can be obtained with abundant oxygen-containing functional groups, similar to that of GO. Compared with the precursor, the obtained nanosheets have better adsorption performance, and can be used as adsorbent to remove methylene blue (50 mg/L) from water with removal efficiency of 95.0% and removal capacity of 23.8 mg/g, respectively. These nanosheets can also be used to remove Cd2+ (56.2 mg/L) with removal efficiency of 88.0% and removal capacity of 24.7 mg/g, respectively. The exfoliation mechanism has been analyzed and interpreted as strong oxygen attacking and subsequent ultrasonic stripping. This work provides an efficient preparation method of 2D graphite nanosheets for functional applications such as excellent adsorbent.
Observations of cold-induced vasodilation in persons with spinal cord injuries
Authors: Kamijo Yoshi-ichiro , Fujita Yasuhisa , Kinoshita Tokio , Hashizaki Takamasa , Murai Kota , Yoshikawa Tatsuya , Umemoto Yasunori , Kaminaka Chikako , Shibasaki Manabu , Tajima Fumihiro , Nishimura Yukihide 
Published: October 2022

Abstract
Study Design: Acute experimental study
Objectives: Cold-induced vasodilation (CIVD) is a local mechanism of protection against frostbite in able-body persons. This study assessed whether CIVD was observed in the sensate and non-sensate area in spinal cord injuries (SCIs) and whether the response patterns were different between the region levels or sites.
Setting: Laboratory of Wakayama Medical University, Japan
Methods: A local cooler device (diameter 4 cm) was placed on the chest (sensate) and thigh (non-sensate) in persons with cervical (SCIC; n=9) and thoracolumbar spinal cord injuries (SCITL; n=9). After the surface temperature was controlled at 33°C for 10 min (baseline), local cooling (LC) with a rate of 0.045°C/s was applied and the temperature was maintained at 15 and 8°C for 15 min of each stage. Skin blood flow (SkBF; laser Doppler flowmetry) was monitored using a 1-mm needle-type probe inserted into its center. CIVD was observed on the both sites in all participants at 8°C LC.
Results: % change in SkBF (%ΔSkBF) on the chest remained unchanged until the end of the 15°C stage in both groups, then it increased at 8°C stage over the baseline. %ΔSkBF on the thigh remained unchanged throughout the measurement in SCIC, but decreased during the periods from 33 to 15°C and from 15 to 8°C, then recovered to around the baseline level at 8°C in SCITL.
Conclusions: CIVD was observed both in the sensate and non-sensate areas in SCIs. The magnitudes of the response were different between the both areas.
WDR12 Facilitates Tumor Progression by Promoting Proliferation and Inhibiting Apoptosis in Colorectal Cancer
Authors: Wen Su , Huang Xueqing , Zeng Hao , An Kangli , Wu Shuang , Bai Jing , Yin Tiejun 
Published: October 2022

Abstract
Background: WD repeat domain 12 (WDR12) encodes a member of the WD-repeat protein family, a component of a nucleolar protein complex that affects the maturation of the large ribosomal subunit, which was highly expressed in colorectal cancer (CRC) tissues compared to para-cancerous tissues. However, its function is unclear in CRC. Thus, our goal was to reveal the biological role of WDR12 in the tumorigenesis and development of CRC.
Method：To investigate the correlation of gene knockdown with CRC malignancy (proliferative and anti-apoptotic) by performing lentivirus-assisted WDR12 knockdown experiments in HCT116 and SW620 model CRC cell lines and Validated in vivo experiments in nude mice. Then the possible mechanism of the downstream pathway of WDR12 was investigated by ingenuity pathway analysis (IPA). Finally, in vitro experiments explored the relationship between RAC1 and WDR12 in cell proliferation and anti-apoptosis.
Result: In-vitro lentivirus-assisted WDR12 gene knockdown experiments in CRC cell lines showed cell proliferation inhibition, decreased cell viability, and promotion of cell apoptosis compared to empty controls. Hereafter, In-vivo tumor formation experiments in nude mice revealed that tumor area, volume, and weight were significantly lower for knockdown WDR12. In addition, Ingenuity Pathway Analysis and Western blot showed that knockdown of WDR12 affected the down-regulation of a series of downstream genes, including RAC1, PLK1, EZH2, and SKP2, which affected cell proliferation, apoptosis, and cell cycle. Functional recovery experiments demonstrated that overexpression of RAC1 recovered the ability of WDR12 to promote cell proliferation and inhibit apoptosis.
Conclusion: In conclusion, WDR12 may be a novel oncogenic factor and a therapeutic target in CRC. Meanwhile, RAC1 may be one of the interacting genes in the downstream pathway of WDR12.
Transanal down-to-up dissection of the distal rectum as a viable approach to achieve total mesorectal excision in laparoscopic sphincter-preserving surgery for rectal cancer near the anus: A study of short- and long-term outcomes of 127 consecutive patients from a single Japanese institution
Authors: Kagami Satoru , Funahashi Kimihiko , Koda Takamaru , Ushigome Toshimitsu , Kaneko Tomoaki , Suzuki Takayuki , Miura Yasuyuki , Nagashima Yasuo , Yoshida Kimihiko , Kurihara Akiharu 
Published: October 2022

Abstract
Background
In rectal cancer (RC) surgery, the complexity of total mesorectal excision (TME) in laparoscopic sphincter-preserving surgery (lap-SPS) for RC near the anus has been a critical issue. Recently, technical assistance via the anus for complete TME has been receiving attention. This study aimed to clarify the transanal down-to-up dissection viability for achieving TME in lap-SPS for RC near the anus.
Methods
We evaluated surgical and oncological outcomes of a total of 127 consecutive patients undergoing either a transanal rectal dissection under direct vision (TARD) mobilizing the most difficult portion of TME via the anus or the transanal TME by using an endoscopic system (TaTME) for achieving TME in lap-SPS for RC near the anus between January 2006 and February 2021.
Results
A total of 127 consecutive patients (87 men), with a median age of 66 years (range 33–86 years), were included. TARD and TaTME were performed for 51 (40.2%) and for 76 (59.8%) patients, respectively. Preoperative treatment was performed for 41 (32.3%) patients, resulting in a complete pathological response in 5 (3.9%) patients. Intersphincteric resection was performed significantly in the TARD group (p < 0.001). Although the TaTME group needed a longer operative time at the transanal portion (p < 0.001), the median blood loss was inferior (p < 0.001). Postoperative complications of the Clavien–Dindo classification grade ≧ 2 developed in 56 (44.1%) patients. Urinary dysfunction (13.4%) was found most frequently, followed by stoma-related complications (12.6%). More patients needing medication for urinary dysfunction were found in the TARD group, but a significant difference was not observed (11.8% vs. 6.6%, p = 0.347). The quality of TME was good for almost all patients. Recurrence developed in 18 (14.2%) patients. The 5-year OS and DFS rates in 127 patients were 90.4% and 83.2%, respectively. The 5-year OS between the two groups was comparable, but the 5-year DFS in the TaTME group was significantly poorer (p = 0.024).
Conclusions
Our data suggested that a transanal down-to-up dissection of the distal rectum might be a viable approach in lap-SPS for RC near the anus. Further studies need to examine the differences between TARD and TaTME.