bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industry 4.0 and healthcare: Context, applications, benefits and challenges
Authors: Kotzias Konstantinos , Bukhsh Faiza A. , Arachchige Jeewanie Jayasinghe , Daneva Maya , Abhishta Abhishta 
Published: November 2022

AbstractIndustry 4.0 refers to the digital transformation in the manufacturing domain through new technology. Currently, it expands well beyond manufacturing, affecting many areas of life and posing implications for all types of business. This paper focuses on the relationships between Industry 4.0 and Healthcare which transitions to increased interconnectivity, automation and smart decision making. The integration context of Industry 4.0 into Healthcare is only partly understood. Little was done until now to consolidate what is known on the integration benefits and the challenges. This article reports results of a systematic mapping study that analysed 69 papers to extract knowledge about the concepts of Industry 4.0 and the emerging Healthcare 4.0., and the relationships between them. We found 10 different perspectives of Healthcare 4.0, ranging from strategic to tactical and operational levels. Next, our results show: (i) nine applications of Industry 4.0 in the Healthcare domain: Augmented Reality and Simulation, Autonomous Robotics, Cybersecurity, Big Data Analytics, Internet of Things, Cloud Computing, Additive Manufacturing and Systems Integration; and (ii) 10 benefits and nine challenges in Healthcare 4.0. The most frequently mentioned benefits are patients' diagnosis, monitoring, treatment, and financial benefits. The most researched challenges are data fragmentation, heterogeneity, complexity, and privacy.
First r-process enhanced star confirmed as a member of the Galactic bulge
Authors: Forsberg R. , Rich R. M. , Nieuwmunster N. , Jönsson H. , Schultheis M. , Ryde N. , Thorsbro B. 
Published: November 2022

Aims. Stars with strong enhancements of r-process elements are rare and tend to be metal-poor, generally with [Fe/H] < −2 dex, and located in the halo. In this work, we aim to investigate a candidate r-process enriched bulge star with a relatively high metallicity of [Fe/H] ~ − 0.65 dex and to compare it with a previously published r-rich candidate star in the bulge.
Methods. We reconsidered the abundance analysis of a high-resolution optical spectrum of the red-giant star 2MASS J18082459-2548444 and determined its europium (Eu) and molybdenum (Mo) abundance, using stellar parameters from five different previous studies. Applying 2MASS photometry, Gaia astrometry, and kinematics, we estimated the distance, orbits, and population membership of 2MASS J18082459-2548444 and a previously reported r-enriched star 2MASS J18174532-3353235.
Results. We find that 2MASS J18082459-2548444 is a relatively metal-rich, enriched r-process star that is enhanced in Eu and Mo, but not substantially enhanced in s-process elements. There is a high probability that it has a Galactic bulge membership, based on its distance and orbit. We find that both stars show r-process enhancement with elevated [Eu/Fe]-values, even though 2MASS J18174532-3353235 is 1 dex lower in metallicity. Additionally, we find that the plausible origins of 2MASS J18174532-3353235 to be either that of the halo or the thick disc.
Conclusions. We conclude that 2MASS J18082459-2548444 represents the first example of a confirmed r-process enhanced star confined to the inner bulge. We assume it is possibly a relic from a period of enrichment associated with the formation of the bar.
HD 20329b: An ultra-short-period planet around a solar-type star found by TESS
Authors: Murgas F. , Nowak G. , Masseron T. , Parviainen H. , Luque R. , Pallé E. , Korth J. , Carleo I. , Csizmadia Sz. , Esparza-Borges E. , Alqasim A. , Cochran W. D. , Dai F. , Deeg H. J. , Gandolfi D. , Goffo E. , Kabáth P. , Lam K. W. F. , Livingston J. , Muresan A. , Osborne H. L. M. , Persson C. M. , Serrano L. M. , Smith A. M. S. , Van Eylen V. , Orell-Miquel J. , Hinkel N. R. , Galán D. , Puig-Subirà M. , Stangret M. , Fukui A. , Kagetani T. , Narita N. , Ciardi D. R. , Boyle A. W. , Ziegler C. , Briceño C. , Law N. , Mann A. W. , Jenkins J. M. , Latham D. W. , Quinn S. N. , Ricker G. , Seager S. , Shporer A. , Ting E. B. , Vanderspek R. , Winn J. N. 
Published: November 2022

Context. Ultra-short-period (USP) planets are defined as planets with orbital periods shorter than one day. This type of planets is rare, highly irradiated, and interesting because their formation history is unknown.
Aims. We aim to obtain precise mass and radius measurements to confirm the planetary nature of a USP candidate found by the Transiting Exoplanet Survey Satellite (TESS). These parameters can provide insights into the bulk composition of the planet candidate and help to place constraints on its formation history.
Methods. We used TESS light curves and HARPS-N spectrograph radial velocity measurements to establish the physical properties of the transiting exoplanet candidate found around the star HD 20329 (TOI-4524). We performed a joint fit of the light curves and radial velocity time series to measure the mass, radius, and orbital parameters of the candidate.
Results. We confirm and characterize HD 20329b, a USP planet transiting a solar-type star. The host star (HD 20329, V = 8.74 mag, J = 7.5 mag) is characterized by its G5 spectral type with M* = 0.90 ± 0.05 M⊙, R* = 1.13 ± 0.02 R⊙, and Teff = 5596 ± 50 K; it is located at a distance d = 63.68 ± 0.29 pc. By jointly fitting the available TESS transit light curves and follow-up radial velocity measurements, we find an orbital period of 0.9261 ± (0.5 × 10−4) days, a planetary radius of 1.72 ± 0.07 R⊗, and a mass of 7.42 ± 1.09 M⊗, implying a mean density of ρp = 8.06 ± 1.53 g cm−3. HD 20329b joins the ~30 currently known USP planets with radius and Doppler mass measurements.
Lying with deceptive implicatures? Solving a puzzle about conflicting results
Authors: Wiegmann Alex 
Published: November 2022

AbstractDoes lying require a speaker to explicitly express something (she believes to be) false, or is it also possible to lie with deceptive implicatures? Given that consistency with ordinary language is a desideratum of any philosophical definition of lying, several studies have addressed this question empirically in recent years. Their findings, however, seem to be in conflict. This paper reports an experiment with 222 participants that investigates the hypothesis that these conflicting results are due to variation regarding whether or not the speaker’s intention to deceive and the implicated content are made explicit. It is found that the presence versus the absence of such explicitness has a strong impact on people’s lie judgements, and can thus account for the conflicting results in the literature.
Perceptual odor qualities predict successful odor identification in old age
Authors: Lindroos Robert , Raj Rohan , Pierzchajlo Stephen , Hörberg Thomas , Herman Pawel , Challma Sandra , Hummel Thomas , Larsson Maria , Laukka Erika J , Olofsson Jonas K 
Published: November 2022

Abstract
Odor identification is a common assessment of olfaction, and it is affected in a large number of diseases. Identification abilities decline with age, but little is known about whether there are perceptual odor features that can be used to predict identification. Here, we analyzed data from a large, population-based sample of 2,479 adults, aged 60 years or above, from the Swedish National study on Aging and Care in Kungsholmen. Participants performed both free and cued odor identification tests. In a separate experiment, we assessed perceived pleasantness, familiarity, intensity, and edibility of all odors in the first sample, and examined how odor identification performance is associated with these variables. The analysis showed that high-intensity odors are easier to identify than low-intensity odors overall, but also that they are more susceptible to the negative repercussions of old age. This result indicates that sensory decline is a major aspect of age-dependent odor identification impairment, and suggests a framework where identification likelihood is proportional to the perceived intensity of the odor. Additional analyses further showed that high-performing individuals can discriminate target odors from distractors along the pleasantness and edibility dimensions and that unpleasant and inedible odors show smaller age-related differences in identification. Altogether, these results may guide further development and optimization of brief and efficient odor identification tests as well as influence the design of odorous products targeted toward older consumers.
Behavioral Response of Unmated Female Plodia interpunctella Hübner (Lepidoptera: Pyralidae) to Synthetic Sex Pheromone Lure
Authors: Gerken Alison R , Dryer Danielle , Abts Shelby R , Campbell James F 
Published: November 2022

Abstract
Indian meal moth, Plodia interpunctella Hübner, is an important pest of stored products in food facilities like processing plants, warehouses, and retail stores. Mating disruption, which uses synthetic pheromone to delay or prevent mating, is a relatively new management tactic for this pest but is becoming widely adopted. However, little is known about the mechanisms behind its efficacy, including how artificial pheromone impacts female behavior. Here we assay behavioral responses of two strains of unmated female P. interpunctella exposed to pheromone. Results show one strain increased the duration of calling behavior while the other decreased calling when exposed to pheromone lures. Time walking decreased, and time cleaning increased for both strains when exposed to pheromone. Time of first walking behavior was also delayed for one strain when exposed to pheromone. Females of both strains were less mobile when exposed to pheromone. These results show autodetection of pheromone by females, but also indicate that strains may vary in behavioral responses. Differing patterns of calling behavior between strains could be driven by either strain-specific genetic differences or laboratory induced effects. Decreasing calling behavior and overall movement during exposure to pheromone could enhance the effectiveness of a mating disruption program. However, increased calling by females in the presence of pheromone may be a competitive response and could increase mating success under certain scenarios. These findings suggest that artificial pheromone associated with monitoring and mating disruption programs has impacts on female behavior and warrants further study to determine the overall impacts on program effectiveness.
Early Postwar Accounts on Jewish Orphans from Transnistria
Authors: Mihăilescu Dana 
Published: November 2022

ABSTRACT
This article focuses on the emotional and social challenges that Romanian Holocaust survivors, particularly children who became orphans, faced in the early postwar period. The author shows how the accounts of Jewish orphans from Transnistria did not initially come from experts, but from published booklets of Jewish survivors and journalists, and Jewish and non-Jewish Romanian press accounts, all of which had divergent agendas. Soon after the War, assessments by psychologists and physicians also appeared. The most important Jewish-Romanian figure to connect these diverse accounts to the psychological state of Romanian-Jewish orphans at the end of the Second World War was Dr. Theodor Loewenstein. In tracking and analyzing these narratives, the author seeks to understand the different representations of Jewish orphans from Transnistria in early postwar Romania.
On Resisting Art
Authors: Harold James 
Published: November 2022

Abstract
What responsibilities do audiences have in engaging with artworks? Certain audience responses seem quite clear: for example, audiences should not vandalize or destroy artworks; they should not disrupt performances. This paper examines other kinds of resisting responses that audiences sometimes engage in, including petitioning the artist to change their works, altering copies of artworks, and creating new artworks in another artist’s fictional world. I argue for five claims: (1) while these actions can sometimes infringe on the rights of artists, the rights of artists are not absolute; (2) the fact that such actions are based on mistaken interpretations of the artworks has no normative weight; (3) there can be reason to object to additions and alterations whose conception of the artwork is morally worse than the original (and so, there can be reason to support additions and alterations whose conception is morally better); (4) petitioning raises special moral problems; and, most important, (5) some of these actions are valuable because they involve creative and aesthetic activity. Those acts of audience resistance that are creative, morally improve on the original work, and that minimize the infringement of the artists’ rights are good, and should be encouraged.
The prediction accuracies of linear-type traits in Czech Holstein cattle when using ssGBLUP or wssGBLUP
Authors: Brzáková Michaela , Bauer Jiří , Steyn Yvette , Šplíchal Jiří , Fulínová Daniela 
Published: November 2022

Abstract
The aim of this study was to assess the contribution of the weighted single-step genomic best linear unbiased prediction (wssGBLUP) method compared to the single-step genomic best linear unbiased prediction (ssGBLUP) method for genomic evaluation of 25 linear-type traits in the Czech Holstein cattle population. The nationwide database of linear-type traits with 6,99,681 records combined with deregressed proofs from Interbull (MACE method) was used as the input data. Genomic breeding values (GEBVs) were predicted based on these phenotypes using ssGBLUP and wssGBLUP methods using the BLUPF90 software. The bull validation test was employed which was based on comparing GEBVs of young bulls (N = 334) with no progeny in 2016. A minimum of 50 daughters with their own performance in 2020 was chosen to verify the contribution to the GEBV prediction, GEBV reliability, validation reliabilities (R2), and regression coefficients (b1). The results showed that the differences between the two methods were negligible. The low benefit of wssGBLUP may be due to the inclusion of a small number of SNPs; therefore, most predictions rely on polygenic relationships between animals. Nevertheless, the benefits of wssGBLUP analysis should be assessed with respect to specific population structures and given traits.
Habitat Diversity, Stability, and Productivity of Malaria Vectors in Irrigated and Nonirrigated Ecosystems in Western Kenya
Authors: Orondo Pauline Winnie , Wang Xiaoming , Lee Ming-Chieh , Nyanjom Steven G , Atieli Harrysone , Ondeto Benyl M , Ochwedo Kevin O , Omondi Collince J , Otambo Wilfred Ouma , Zhou Guofa , Zhong Daibin , Githeko Andrew K , Kazura James W , Yan Guiyun 
Published: November 2022

Abstract
Several sub-Saharan African countries rely on irrigation for food production. This study examined the impact of environmental modifications resulting from irrigation on the ecology of aquatic stages of malaria vectors in a semi-arid region of western Kenya. Mosquito larvae were collected from irrigated and non-irrigated ecosystems during seasonal cross-sectional and monthly longitudinal studies to assess habitat availability, stability, and productivity of anophelines in temporary, semipermanent, and permanent habitats during the dry and wet seasons. The duration of habitat stability was also compared between selected habitats. Emergence traps were used to determine the daily production of female adult mosquitoes from different habitat types. Malaria vectors were morphologically identified and sibling species subjected to molecular analysis. Data was statistically compared between the two ecosystems. After aggregating the data, the overall malaria vector productivity for habitats in the two ecosystems was estimated. Immatures of the malaria vector (Anopheles arabiensis) Patton (Diptera: Culicidae) comprised 98.3% of the Anopheles in both the irrigated and non-irrigated habitats. The irrigated ecosystem had the most habitats, higher larval densities, and produced 85.8% of emerged adult females. These results showed that irrigation provided conditions that increased habitat availability, stability, and diversity, consequently increasing the An. arabiensis production and potential risk of malaria transmission throughout the year. The irrigated ecosystems increased the number of habitats suitable for Anopheles breeding by about 3-fold compared to non-irrigated ecosystems. These results suggest that water management in the irrigation systems of western Kenya would serve as an effective method for malaria vector control.
The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations
Authors: Ament-Velásquez Sandra Lorena , Gilchrist Ciaran , Rêgo Alexandre , Bendixsen Devin P , Brice Claire , Grosse-Sommer Julie Michelle , Rafati Nima , Stelkens Rike 
Published: November 2022

AbstractAdaptation from standing genetic variation is an important process underlying evolution in natural populations, but we rarely get the opportunity to observe the dynamics of fitness and genomic changes in real time. Here, we used experimental evolution and Pool-Seq to track the phenotypic and genomic changes of genetically diverse asexual populations of the yeast Saccharomyces cerevisiae in four environments with different fitness costs. We found that populations rapidly and in parallel increased in fitness in stressful environments. In contrast, allele frequencies showed a range of trajectories, with some populations fixing all their ancestral variation in &lt;30 generations and others maintaining diversity across hundreds of generations. We detected parallelism at the genomic level (involving genes, pathways, and aneuploidies) within and between environments, with idiosyncratic changes recurring in the environments with higher stress. In particular, we observed a tendency of becoming haploid-like in one environment, whereas the populations of another environment showed low overall parallelism driven by standing genetic variation despite high selective pressure. This work highlights the interplay between standing genetic variation and the influx of de novo mutations in populations adapting to a range of selective pressures with different underlying trait architectures, advancing our understanding of the constraints and drivers of adaptation.
Crystal structure of monkeypox H1 phosphatase, an antiviral drug target
Authors: Cui Wen , Huang Haojun , Duan Yinkai , Luo Zhi , Wang Haofeng , Zhang Tenan , Nguyen Henry C , Shen Wei , Su Dan , Li Xi , Ji Xiaoyun , Yang Haitao , Wang Wei 
Published: November 2022

Abstract
The current monkeypox outbreak has caused over 73,000 global cases, but the effective treatments are very limited. The dual specific phosphatase (H1) from monkeypox antagonizes the immune response and is crucial for viral replication, making it an attractive antiviral target. Here we determined a 1.8-Å crystal structure of H1, which forms a domain swapped dimer resembling a butterfly. Each active site, which consists of a Cys-Arg-Asp triad, captures a phosphate ion. The observed conformation mimics the final step of catalysis prior to product release. The crystal structure provides a strong foundation for the discovery of new antivirals against this emerging worldwide pathogen.
Auditory Hallucinations and Self-Injurious Behavior in General Population Adolescents: Modeling Within-Person Effects in the Tokyo Teen Cohort
Authors: Stanyon Daniel , DeVylder Jordan , Yamasaki Syudo , Yamaguchi Satoshi , Ando Shuntaro , Usami Satoshi , Endo Kaori , Miyashita Mitsuhiro , Kanata Sho , Morimoto Yuko , Hosozawa Mariko , Baba Kaori , Nakajima Naomi , Niimura Junko , Nakanishi Miharu , Hiraiwa-Hasegawa Mariko , Kasai Kiyoto , Nishida Atsushi 
Published: November 2022

AbstractBackground and HypothesesA wealth of evidence suggests that adolescent psychotic experiences (PEs), and especially auditory hallucinations (AHs), are associated with an increased risk for self-injurious behavior (SIB). However, the directionality and specificity of this association are not well understood, and there are no published studies investigating within-person effects over time. The present study aimed to test whether AHs and SIB prospectively increase reciprocal risk at the individual level during early-to-middle adolescence.Study DesignThree waves (12y, 14y, and 16y) of self-reported AHs and SIB data from a large Tokyo-based adolescent birth cohort (N = 2825) were used. Random Intercept Cross-Lagged Panel Model (RI-CLPM) analysis was conducted to test the within-person prospective associations between AHs and SIB.Study ResultsAt the within-person level, AHs were associated with subsequent SIB over the observation period (12y–14y: β = .118, P &lt; .001; 14–16y: β = .086, P = .012). The reverse SIB-&gt;AHs relationship was non-significant at 12–14y (β = .047, P = .112) but emerged from 14y to 16y as the primary direction of influence (β = .243, P &lt; .001). Incorporating depression as a time-varying covariate did not meaningfully alter model estimates.ConclusionsA complex bi-directional pattern of relationships was observed between AHs and SIB over the measurement period, and these relationships were independent of depressive symptoms. Adolescent AHs may be both a predictor of later SIB and also a manifestation of SIB-induced psychological distress.
Evolution of a globally unique SARS-CoV-2 Spike E484T monoclonal antibody escape mutation in a persistently infected, immunocompromised individual
Authors: Halfmann Peter J , Minor Nicholas R , Haddock III Luis A , Maddox Robert , Moreno Gage K , Braun Katarina M , Baker David A , Riemersa Kasen K , Prasad Ankur , Alman Kirsten J , Lambert Matthew C , Florek Kelsey , Bateman Allen , Westergaard Ryan , Safdar Nasia , Andes David R , Kawaoka Yoshihiro , Fida Madiha , Yao Joseph D , Friedrich Thomas C , O’Connor David H 
Published: November 2022

Abstract
Prolonged infections in immunocompromised individuals may be a source for novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants, particularly when both the immune system and antiviral therapy fail to clear the infection and enable within-host evolution. Here we describe a 486-day case of SARS-CoV-2 infection in an immunocompromised individual. Following monotherapy with the monoclonal antibody Bamlanivimab, the individual’s virus acquired resistance, likely via the earliest known occurrence of Spike amino acid variant E484T. Recently, E484T has arisen again as a derivative of E484A in the Omicron Variant of Concern, supporting the hypothesis that prolonged infections can give rise to novel variants long before they become prevalent in the human population.