bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world experience with capmatinib in MET exon 14-mutated non-small cell lung cancer (RECAP): a retrospective analysis from an early access program
Authors: Illini Oliver , Fabikan Hannah , Swalduz Aurélie , Vikström Anders , Krenbek Dagmar , Schumacher Michael , Dudnik Elizabeth , Studnicka Michael , Öhman Ronny , Wurm Robert , Wannesson Luciano , Peled Nir , Kian Waleed , Bar Jair , Daher Sameh , Addeo Alfredo , Rotem Ofer , Pall Georg , Zer Alona , Saad Akram , Cufer Tanja , Sorotsky Hadas Gantz , Hashemi Sayed M. S. , Mohorcic Katja , Stoff Ronen , Rovitsky Yulia , Keren-Rosenberg Shoshana , Winder Thomas , Weinlinger Christoph , Valipour Arschang , Hochmair Maximilian J. 
Published: June 2022

Background: Patients with non-small cell lung cancer (NSCLC) presenting with mesenchymal–epithelial transition ( MET) exon 14 skipping mutation have an unfavorable prognosis with standard treatments. Capmatinib is a selective MET inhibitor, which showed promising efficacy in this patient population in early trials. Methods: We performed a retrospective, international, multicenter efficacy and safety analysis in patients with NSCLC treated with capmatinib in an early access program between March 2019 and December 2021. Results: Data from 81 patients with advanced MET exon 14 mutated NSCLC treated with capmatinib in first- or later-line therapy were analyzed. Median age was 77 years (range, 48–91), 56% were women, 86% had stage IV disease, and 27% had brain metastases. For all patients, the objective response rate (ORR) to capmatinib was 58% (95% CI, 47–69), whereas it was 68% (95% CI, 50–82) in treatment-naïve and 50% (95% CI, 35–65) in pretreated patients. The median progression-free survival was 9.5 months (95% CI, 4.7–14.3), whereas it was 10.6 months (95% CI, 5.5–15.7) in first-line and 9.1 months (95% CI, 3.1–15.1) in pretreated patients. After a median follow-up of 11.0 months, the median overall survival was 18.2 months (95% CI, 13.2–23.1). In patients with measurable brain metastases ( n = 11), the intracranial ORR was 46% (95% CI, 17–77). Capmatinib showed a manageable safety profile. Grade ⩾ 3 treatment-related adverse events included peripheral edema (13%), elevated creatinine (4%), and elevated liver enzymes (3%). Conclusion: In patients with MET exon 14 skipping mutation, capmatinib showed durable systemic and intracranial efficacy and a manageable safety profile. This analysis confirms previously reported phase II data in a real-world setting.
Tobacco Use Increases the Adjusted Risk of Revision Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis
Authors: Gill Amarbir S. , Meeks Huong , Curtin Karen , Alt Jeremiah A. 
Published: June 2022

Background Large epidemiologic studies have suggested that a history of tobacco use may be associated with an increased risk of developing chronic rhinosinusitis (CRS). The impact of tobacco use on revision rates of endoscopic sinus surgery (ESS), however, remains limited. Objective This study seeks to define the independent risk of tobacco use (active or prior) on revision rates of ESS among a large cohort of patients with CRS. Methods A state population database was queried for patients age ≥18 years with CRS who underwent at least one ESS between 1996 and 2018. Demographic characteristics, history of ESS, and tobacco use status were compared across patients with CRS, using t tests for continuous variables and χ2 tests for categorical variables. Unadjusted and adjusted logistic regression models were used to understand the impact of tobacco status on revision surgery. Results The final analysis included 34 350 patients (29 916 CRS with no revision surgery and 4434 CRS with revision surgery). Unadjusted regression analysis demonstrated an increased odds of undergoing revision ESS (OR 1.12, 95% CI: 1.00–1.25, P = .05) among males with a history of tobacco use and CRS. Adjusted regression analysis demonstrated that the risk of revision ESS among CRS patients with a history of asthma and tobacco use was 1.72-fold, while the risk among CRS patients who were tobacco users without asthma was 1.11-fold. Conclusion History of tobacco use is an independent risk factor for revision ESS among patients with CRS.
Examining the adaptability and validity of interRAI acute care quality indicators in a surgical context
Authors: Wood Timothy , Chatfield Mark , Gray Leonard , Peel Nancye , Freeman Shannon , Martin-Khan Melinda 
Published: June 2022

Background: Currently, the use of quality indicators in the surgical setting may be challenged by diverse patient needs, clinical complexity, and health trajectories. Therefore, the objective of this study was to examine the adaptability of existing quality indicators to a surgical context and propose new time points. Methods: A multi-method approach included an environmental scan of the literature, consultation with multinational experts, and analysis of surgical patient data. Quality indicators from the nurse-administered interRAI Acute Care instrument were examined within a surgical context using secondary data from a hospital in Brisbane, Australia (N = 1006 surgical cases). Results: A lack of relevancy of existing time points can preclude meaningful quality indicator measurement. Definitions of some quality indicators were adapted to ensure relevancy for the surgical population. As well, a surgical baseline (measured preoperative and post-injury) and a 48-h postoperative time point were added to the existing measurement timeline. Conclusion: Distinct measurement timelines were created for elective and non-elective surgical patients. The use of surgery-specific time points that can be embedded into an existing Acute Care measurement framework supports consistent quality indicator reporting. This study represents the first steps towards standardized quality reporting for health information systems across different care settings.
Undernutrition and associated factors among rural pregnant women in Eastern Ethiopia
Authors: Gebremichael Berhe , Misgana Tadesse , Tamiru Dawit , Tariku Mandaras , Tesfaye Dejene , Alemu Daniel , Weldesenbet Adisu Birhanu , Dheresa Merga 
Published: June 2022

Objectives: Maternal undernutrition is a burning issue in Ethiopia. However, updated evidence is limited in the eastern part of the country; particularly the mental health-related factors of undernutrition. The study, hence, aimed at assessing the prevalence and predictors of undernutrition among rural pregnant women in eastern Ethiopia. Methods: A cross-sectional research was carried out at a community level among 1015 randomly selected pregnant women. A structured questionnaire was used to collect the data through face-to-face interviews. The characteristics of participants were described and summarized by frequencies, percentages, and summary measures. Logistic regression was performed to find out factors related to undernutrition. Results: The prevalence of undernutrition was 43.8% (95% confidence interval: 40.8, 47.0). Early marriage (adjusted odds ratio = 2.63, confidence interval: 2.00, 3.47), no antenatal care follow-up (adjusted odds ratio = 1.73, 95% confidence interval: 1.31, 2.29), inadequately diversified diet (adjusted odds ratio = 2.48, 95% confidence interval: 1.77, 3.48), current substance use (adjusted odds ratio = 1.50, 95% confidence interval: 1.02, 2.19), history of mental illness (adjusted odds ratio = 2.44, 95% confidence interval: 1.02, 5.82), and common mental disorders (adjusted odds ratio = 1.81, 95% confidence interval: 1.34, 2.43) were the significant predictors of undernutrition among pregnant women. Conclusions: Undernutrition was a significant public health issue among rural pregnant women. Age at first marriage, antenatal care follow-up, dietary diversity, current substance use, history of mental illness, and common mental disorder were the independent predictors of undernutrition. Therefore, the health offices of Kersa and Haramaya districts should invest their efforts to prevent undernutrition among pregnant women through nutrition counselling and education, and mental health and psychosocial support.
Use of Guideline-Based Therapy for Diabetes, Coronary Artery Disease, and Chronic Kidney Disease After Acute Kidney Injury: A Retrospective Observational Study
Authors: Madan Sunchit , Norman Patrick A. , Wald Ron , Neyra Javier A. , Meraz-Muñoz Alejandro , Harel Ziv , Silver Samuel A. 
Published: June 2022

Background: Survivors of acute kidney injury (AKI) are at a high risk for cardiovascular complications. An underrecognition of this risk may contribute to the low utilization of relevant guideline-based therapies in this population. Objective: We sought to assess accordance with guideline-based recommendations for survivors of AKI with diabetes, coronary artery disease (CAD), and preexisting chronic kidney disease (CKD) in a post-AKI clinic, and identify factors that may be associated with guideline accordance. Design: Retrospective cohort study. Setting: Post-AKI clinics at 2 tertiary care centers in Ontario, Canada. Patients: We included adult patients seen in both post-AKI clinics between 2013 and 2019 who had at least 2 clinic visits within 24 months of an index AKI hospitalization. Measurements: We assessed accordance to recommendations from the most recent North American and international guidelines available at the time of study completion for diabetes, CAD, and CKD. Methods: We compared guideline accordance between visits using the Cochran Mantel Haenszel test. We used multivariable Poisson regression to identify prespecified factors associated with accordance. Results: Of 213 eligible patients, 192 (90%) had Kidney Disease Improving Global Outcomes Stage 2-3 AKI, 91 (43%) had diabetes, 76 (36%) had CAD, and 88 (41%) had preexisting CKD. From the first clinic visit to the second, there was an increase in angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACE-I/ARB) use across all disease groups—from 33% to 46% ( P = .028) in patients with diabetes, from 30% to 57% ( P = .002) in patients with CAD, and from 16% to 35% ( P < .001) in patients with preexisting CKD. Statin use increased in patients with preexisting CKD from 64% to 71% ( P = .034). Every 25 μmol/L rise in the discharge serum creatinine was associated with a 19% (95% confidence interval [CI], 8%-28%) and 12% (95% CI, 2%-21%) lower likelihood of being on an ACE-I/ARB in patients with diabetes and preexisting CKD, respectively. Limitations: The study lacked a comparison group that received usual care. The small sample and multiple comparisons make false positives possible. Conclusion: There is room to improve guideline-based cardiovascular risk factor management in survivors of AKI, particularly ACE-I/ARB use in patients with an elevated discharge serum creatinine.
Household Dietary Diversity and Associated Factors among Rural Residents of Gomole District, Borena Zone, Oromia Regional State, Ethiopia
Authors: Aliyo Alqeer , Golicha Wako , Fikrie Anteneh 
Published: June 2022

Background Low dietary diversity is the main public health issue in developing countries. Despite its burden, there is a paucity of information on the dietary diversity of households and related factors in rural residents of southern Ethiopia. Therefore, this study assessed household dietary diversity and associated factors among rural residents of Gomole district. Methods A community-based cross-sectional study design was conducted from November 1 to December 30, 2020, among 554 randomly selected rural households. Data were collected by using pretested structured face-to-face interviews about dietary intake by any household members within the past 24 h. The data were coded and entered into Epi data 3.1 and analyzed using Statistical Package for Social Sciences version 23. Both descriptive and analytic statistics were employed. Adjusted odds ratios (AORs) together with 95% confidence intervals and p values of less than 0.05 were used to declare statistical significance. Results Out of the total, 19% (95%; CI = 15.7–22.2) of households had adequate dietary diversity scores. The mean (±SD) dietary diversity score was 5.12 (±1.6). The most consumed food groups in the study area were cereals/grains (96.4%), condiments (salt and beverages (tea)) (84.3%) and milk and milk products (80%). The sex of the household head (AOR = 2.31, 95% CI: 1.04–5.13), bank account ownership (AOR = 2.18, 95% CI: 1.04–4.59), and livestock ownership (AOR = 4.75, 95% CI: 1.35–16.73) were positively associated with dietary diversity. However, distance to the marketplace (AOR = 0.11, 95% CI: 0.02–0.56) was negatively associated with adequate dietary diversity. Conclusion There is low dietary diversity among households of study area. Improving livestock rearing and bank accounts should be strengthened through strong intersectional collaboration to alleviate the problem.
Health-Related Quality of Life and Social Support of Elderly Lung and Gastrointestinal Cancer Patients Undergoing Chemotherapy
Authors: Kyriazidou Eleni , Alevizopoulos Nektarios , Dokutsidou Eleni , Kavga Anna , Kalemikerakis Ioannis , Konstantinidis Theocharis , Tsatsou Ioanna , Govina Ourania 
Published: June 2022

Introduction Increasing life expectancy has led to a higher incidence of cancer in the elderly, thus making them vulnerable and worsening their health-related quality of life (HRQoL) and their need for support. Objective The aim of this study was to examine the HRQoL and social support in elderly Greek lung and gastrointestinal cancer patients undergoing chemotherapy. Methods This was a descriptive, cross-sectional study of 104 elderly cancer patients, who were receiving chemotherapy in the outpatient department and inpatient ward of a General Hospital in Athens. The data were collected using purposive sampling between December 2019 and May 2020, and included demographic and clinical characteristics, the HRQoL questionnaire, Short Form 36 (SF36), and the Personal Resource Questionnaire (PRQ-2000). Results The participants' median age was 72 years; the majority were male (62.5%) and had lung cancer (57.7%). The SF36 data revealed a relatively moderate (42.7–62.61) HRQoL in most subscales. The “Pain” subscale recorded the highest score (75.0), and the “social function” subscale the lowest (42.79). The PQR-2000 indicated a satisfactory level of social support (81.65), with values ranging between 48 and 105; married patients with higher education scored more highly ( p < .05). Patients aged 65–75 years reported better HRQoL and greater social support than older patients. In addition, patients with their own family and a relatively high income reported better HRQoL and social support compared to single individuals, with low income, who were cared for by their children. Positive and statistically significant ( p < .05) correlations were found between the SF36 subscales of role functioning/physical, vitality, general health, emotional well-being and the PRQ-2000. Conclusion The HRQoL and social support of elderly cancer patients positively affect the course of their health. Healthcare systems and social services should address the multiplying needs of these patients with targeted interventions to support their well-being.
Superior Labrum Anterior Posterior Clinical Exam Techniques
Authors: Pike J. Mattison , Singh Suvleen K. , Kibler W. Ben , Eichinger Josef K. 
Published: June 2022

Background: Superior labrum anterior posterior (SLAP) lesions are prevalent in athletes and the elderly. Therefore, acquiring accurate diagnoses is beneficial for improvement in return to play for athletes and quality of life. A well-done clinical examination can help detect these lesions leading to an early and accurate diagnosis. Indications: Being able to perform a clinical examination for diagnosing SLAP lesions is an important tool for a doctor to know. Currently, there is not a centralized location with published videos that show how to perform these examinations and describe their attributes. This video helps clinicians quickly ascertain how to perform these examinations and learn about the statistical measures associated with them. Technique Description: The 7 exams shown are as follows: modified dynamic labral shear (DLS) test, speed’s test, active compression test (O’Brien test), anterior slide test, crank test, Kim test, and the Jerk test. Results: These tests have a wide variety of statistical measures making different ones useful for specific results such as ruling in or ruling out labral lesions. The tests with the highest sensitivity are the modified dynamic labral shear test (72%) and Kim test (61%-92%). The tests with the highest specificity are the modified dynamic labral shear test (98%), anterior slide test (81%-89%), Kim test (88%-99%), and the Jerk test (94%-99%). All of these have a 95% confidence interval except DLS test. Discussion/Conclusions: Some of these tests are more reliable than others when diagnosing labral lesions. Since the dynamic labral shear test and Kim test have the highest sensitivity, they are the most useful tests at ruling out labral lesions. These tests along with the anterior slide test and the Jerk test are the most useful for ruling in labral lesions due to their high specificity. Even though these tests have been proven to be more reliable than others, it still matters which tests the doctors feel comfortable performing accurately for them to use in the clinical setting.
Genome-wide identification of R2R3-MYB gene family and association with anthocyanin biosynthesis in Brassica species
Authors: Chen Daozong , Chen Haidong , Dai Guoqiang , Zhang Haimei , Liu Yi , Shen Wenjie , Zhu Bo , Cui Cheng , Tan Chen 
Published: June 2022

AbstractBrassica species include important oil crops and vegetables in the world. The R2R3-MYB gene participates in a variety of plant functions, including the activation or inhibition of anthocyanin biosynthesis. Although previous studies have reported its phylogenetic relationships, gene structures, and expression patterns in Arabidopsis, the number and sequence variation of this gene family in Brassica crops and its involvement in the natural quantitative variation in anthocyanin biosynthesis regulation are still largely unknown. In this study, by using whole genome sequences and comprehensive genome-wide comparative analysis among the six cultivated Brassica species, 2120 R2R3-MYB genes were identified in six Brassica species, in total These R2R3-MYB genes were phylogenetically clustered into 12 groups. The R2R3-MYB family between A and C subgenomes showed better collinearity than between B and C and between A and B. From comparing transcriptional changes of five Brassica species with the purple and green leaves for the detection of the R2R3-MYB genes associated with anthocyanin biosynthesis, 7 R2R3-MYB genes were co-differentially expressed. The promoter and structure analysis of these genes showed that some variations between non-coding region, but they were highly conserved at the protein level and spatial structure. Co-expression analysis of anthocyanin-related genes and R2R3-MYBs indicated that MYB90 was strongly co-expressed with TT8, and they were co-expressed with structural genes F3H, LDOX, ANS and UF3GT at the same time. These results further clarified the roles of the R2R3-MYBs for leaf coloration in Brasica species, which provided new insights into the functions of the R2R3-MYB gene family in Brasica species.
Older adults’ facial characteristics compared to young adults’ in correlation with edentulism: a cross sectional study
Authors: Skomina Zala , Kočevar Dominik , Verdenik Miha , Hren Nataša Ihan 
Published: June 2022

Abstract
Background
Facial ageing is a result of superficial wrinkling combined with changes to the underlying soft tissues and skeleton. The influence of tooth loss, as a geriatric characteristic, on facial appearance is still poorly explained. The aim was to evaluate the facial characteristics of older adults, correlate these characteristics with the dentition and make comparisons with young adults using a non-invasive 3D methodology.

Methods
90 participants older than 65 years, classified into 3 subgroups (edentulous, partially edentulous, toothed) and 30 young adults were evaluated. Their faces were scanned with an optical Artec 3D-scanner. Cephalometric analyses were made using the RapidForm computer program. An independent t-test and ANOVA were used for the comparisons. Pairwise, post-hoc tests were applied with respect to the significant differences (P < 0.05).

Results
The faces of older adults are wider and longer because of the longer middle facial height. Older adults also have a longer upper lip, a larger nose, a smaller nasolabial angle (due to the nasal ptosis), narrower upper- and lower-lip vermilions and larger facial and lower-facial-height angles, resulting in a flat facial profile.
The facial changes due to ageing are the most pronounced in the edentulous. In comparison with the toothed, they have a smaller facial height due to the smaller lower facial height, larger nasolabial angle, smaller mouth width, shorter upper lip and narrower lip vermilions. Their profile is flatter and their lips are more retruded.

Conclusions
The proportions of the whole face are changed in older adults and they are the most expressed when this is combined with tooth loss.
The mediation role of psychological capital between family relationship and antenatal depressive symptoms among women with advanced maternal age: a cross sectional study
Authors: Zeng Kai , Li Yang , Yang Rumei 
Published: June 2022

Abstract
Background
Due to changes in family policy in China, pregnancy at advanced age (30 years old or above) is prevalent. Advanced maternal age is known to be related to a variety of negative health outcomes, including antenatal depression. Family relationship quality might be an important factor for antenatal depressive symptoms among Chinese women with advanced maternal age. However, the underlying mechanisms in which family relationship quality can affect antenatal depressive symptoms among this population and how positive psychological capital (PsyCap) intervenes in this impact are not clear.

Objectives
To describe the prevalence and demographic characteristics of antenatal depressive symptoms among Chinese pregnant women with advanced maternal age, and to explore the mediation effect of PsyCap in the associations between family relationship quality and antenatal depressive symptoms.

Methods
We conducted a cross-sectional survey at a tertiary hospital in China. A total of 192 women with maternal age of 30 years or older completed the questionnaires. Data on antenatal depressive symptoms, PsyCap, family relationship quality and demographic characteristics were collected. The multiple mediation models in SPSS’s PROCESS macro were used to test whether PsyCap mediated the relationship between family relationship quality and antenatal depressive symptoms.

Results
Approximately 28.6% of participants had antenatal depressive symptoms and 6.8% reported poor family relationship quality. Participants with higher education (p = .02) and better family relationship quality (p = .00) were less likely to have antenatal depressive symptoms. PsyCap collectively (β = 1.14, p < .05), or more specifically resilience (β = 0.61, p < .05) significantly mediated the relationship between poor family relationship quality and antenatal depressive symptoms.

Discussion
The relationship between family relationship quality and antenatal depressive symptoms can be mediated by PsyCap collectively or via resilience specifically. It is important to screen antenatal depressive symptoms among pregnant women with advanced age, especially those who have poor family relationship quality. Counseling and psychotherapy initiatives for resilience-enhancing training for pregnant women at advanced age may provide a promising target to break the link between poor family relationship quality and antenatal depressive symptoms.