bluuebunny/crossref_metadata_2025_split huggingface dataset:
AGILE Observations of GRB 220101A: A “New Year's Burst” with an Exceptionally Huge Energy Release
Authors: Ursi A. , Romani M. , Piano G. , Verrecchia F. , Longo F. , Pittori C. , Tavani M. , Bulgarelli A. , Cardillo M. , Casentini C. , Cattaneo P. W. , Costa E. , Feroci M. , Fioretti V. , Foffano L. , Lucarelli F. , Marisaldi M. , Morselli A. , Pacciani L. , Parmiggiani N. , Tempesta P. , Trois A. , Vercellone S. 
Published: July 2022

Abstract
We report the AGILE observations of GRB 220101A, which took place at the beginning of 2022 January 1 and was recognized as one of the most energetic gamma-ray bursts (GRBs) ever detected since their discovery. The AGILE satellite acquired interesting data concerning the prompt phase of this burst, providing an overall temporal and spectral description of the event in a wide energy range, from tens of kiloelectronvolts to tens of megaelectronvolts. Dividing the prompt emission into three main intervals, we notice an interesting spectral evolution, featuring a notable hardening of the spectrum in the central part of the burst. The average fluxes encountered in the different time intervals are relatively moderate, with respect to those of other remarkable bursts, and the overall fluence exhibits a quite ordinary value among the GRBs detected by MCAL. However, GRB 220101A is the second farthest event detected by AGILE, and the burst with the highest isotropic equivalent energy of the entire MCAL GRB sample, releasing E
iso = 2.54 × 1054 erg and exhibiting an isotropic luminosity of L
iso = 2.34 × 1052 erg s−1 (both in the 400 keV–10 MeV energy range). We also analyzed the first 106 s of the afterglow phase, using the publicly available Swift-XRT data, carrying out a theoretical analysis of the afterglow, based on the forward shock model. We notice that GRB 220101A is with high probability surrounded by a wind-like density medium, and that the energy carried by the initial shock shall be a fraction of the total E
iso, presumably near ∼50%.
Sensitivity of the Hubble Constant Determination to Cepheid Calibration
Authors: Mörtsell Edvard , Goobar Ariel , Johansson Joel , Dhawan Suhail 
Published: July 2022

Abstract
Motivated by the large observed diversity in the properties of extragalactic extinction by dust, we reanalyze the Cepheid calibration used to infer the Hubble constant, H
0, from Type Ia supernovae, using Cepheid data in 19 Type Ia supernova host galaxies from Riess et al. and anchor data from Riess et al. Unlike the SH0ES team, we do not enforce a fixed universal color–luminosity relation to correct the Cepheid magnitudes. Instead, we focus on a data-driven method, where the optical colors and near-infrared magnitudes of the Cepheids are used to derive individual color–luminosity relations for each Type Ia supernova host and anchor galaxy. We present two different analyses, one based on Wesenheit magnitudes, resulting in H
0 = 73.2 ± 1.3 km s−1 Mpc−1, a 4.2σ tension with the value inferred from the cosmic microwave background. In the second approach, we calibrate an individual extinction law for each galaxy, with noninformative priors using color excesses, yielding H
0 = 73.9 ± 1.8 km s−1 Mpc−1, in 3.4σ tension with the Planck value. Although the two methods yield similar results, in the latter approach, the Hubble constants inferred from the individual Cepheid absolute distance calibrator galaxies range from H
0 = 68.1 ± 3.5 km s−1 Mpc−1 to H
0 = 76.7 ± 2.0 km s−1 Mpc−1. Taking the correlated nature of H
0 inferred from individual anchors into account, and allowing for individual extinction laws, the Milky Way anchor is in 2.1–3.1 σ tension with the NGC 4258 and Large Magellanic Cloud anchors, depending on prior assumptions regarding the color–luminosity relations and the method used for quantifying the tension.
K2 Photometry on Oscillation Mode Variability: The New Pulsating Hot B Subdwarf Star EPIC 220422705
Authors: Ma Xiao-Yu , Zong Weikai , Fu Jian-Ning , Reed M. D. , Wang Jiaxin , Charpinet Stéphane , Su Jie 
Published: July 2022

Abstract
We present an analysis of oscillation mode variability in the hot B subdwarf star EPIC 220422705, a new pulsator discovered from ∼78 days of K2 photometry. The high-quality light curves provide a detection of 66 significant independent frequencies, from which we identified nine incomplete potential triplets and three quintuplets. Those g- and p-multiplets give rotation periods of ∼36 and 29 days in the core and at the surface, respectively, potentially suggesting a slightly differential rotation. We derived a period spacing of 268.5 s and 159.4 s for the sequence of dipole and quadrupole modes, respectively. We characterized the precise patterns of amplitude and frequency modulations (AM and FM) of 22 frequencies with high enough amplitude for our science. Many of them exhibit intrinsic and periodic patterns of AM and FM, with periods on a timescale of months as derived by the best fitting and Markov Chain Monte Carlo test. The nonlinear resonant mode interactions could be a natural interpretation for such AMs and FMs after other mechanisms are ruled out. Our results are the first step to building a bridge between mode variability from K2 photometry and the nonlinear perturbation theory of stellar oscillation.
Implementation of Healthy Living Community Movement Supported Automatic Telehealth Machine for Public Health at Poltekkes Kemenkes Palu
Authors: Zainul Zainul , Junaidi Junaidi , Nuzul Sigit Mohammad , Bungawati Andi , Nasrul Nasrul , Hafid Fahmi 
Published: July 2022

Background: Indonesia faces serious challenges from a double burden disease caused by changes in people's lifestyles. Since 2010, Non-communicable diseases (NCDs) include hypertension, stroke, heart disease, and diabetes have taken up a growing share of health-care resources. The coronavirus disease epidemic of 2019 (COVID 19) caused by the new coronavirus SARS-CoV2 is the most serious global health issue. Patients with COVID-19 had more hypertension, diabetes, and other cardiovascular diseases, which all require routine health monitoring. Health monitoring will greatly develop along with the development of technology and information 4.0. This includes nursing services in the future that will take advantage of developments in information technology.
Objective: This study aims to implement the healthy living community movement programs using Automatic Telehealth Machine (ATMs) as internet of things for health checking and education at Politeknik Kesehatan Kemenkes Palu.
Methods: This research method is a quasi-experimental intervention research. The population of study were 167 employees of Poltekkes Kemenkes Palu. Sampling process used simple random sampling method with sample size consist of 96 people. The study revealed that majority of respondents were gender and aged, physical activity was generally good, and fruits intake was also good. The measuring instrument used are ATMs device and a questionnaire that has been tested for validity and reliability. Analysis of research data using univariate test (frequency distribution) and bivariate test (t test or alternatives)
Results: The variables that were significantly related to systole were gender and age category (p = 0.03). The variables which were significantly related to diastole were gender (p = 0.02) and age category (p = 0.01). The results revealed that gender, age, physical activity and fruits intake was not associated with total cholesterol levels.
Conclusions: Automatic Telehealth Machine (ATMs) can be implemented for health checking and education in healthy living community movement programs
Simplified Ankylosing Spondylitis Disease Activity Score (SASDAS) Versus ASDAS: A Post Hoc Analysis of a Randomized Controlled Trial
Authors: Schneeberger Emilce E. , Citera Gustavo , de Leon Dario Ponce , Szumski Annette E. , Kwok Kenneth , Cutri Mariel , Dougados Maxime 
Published: July 2022

ObjectiveTo compare the Simplified Ankylosing Spondylitis Disease Activity Score (SASDAS) against the Ankylosing Spondylitis Disease Activity Score (ASDAS) for measuring and categorizing disease activity using data from the EMBARK trial (ClinicalTrials.gov:NCT01258738), a randomized controlled trial of etanercept (ETN) for axial spondyloarthritis (axSpA).MethodsPatients with early active axSpA received ETN 50 mg once weekly (n = 106) or placebo (PBO; n = 109) for 12 weeks in a double-blind manner; they then received open-label ETN for 92 weeks. For this analysis, ASDAS–C-reactive protein (CRP) and SASDAS-CRP were calculated at baseline, week 12, and week 24. The SASDAS was calculated by the linear addition of the ASDAS components without adjustment.ResultsA very strong correlation, as determined by the Spearman correlation coefficient, was observed between the ASDAS and SASDAS for continuous variables at baseline and during treatment. For pooled categorical data at baseline, the SASDAS placed 69.9% of patients in the same disease categories as the ASDAS but overestimated for 17.8% of patients and underestimated for 12.2% of patients. A similar pattern was seen postbaseline. Cohen weightedstatistics for all individual and pooled treatments and timepoints (0.54-0.73) reflected moderate to substantial agreement. The capacity to differentiate between treatments (ie, ETN and PBO/ETN) was higher with the ASDAS (effect size −0.74, 95% CI −1.03 to −0.46) compared with the SASDAS (effect size −0.51, 95% CI −0.79 to −0.23), but sensitivity to change was generally similar.ConclusionA very strong correlation between the SASDAS and ASDAS was observed when considering continuous variables; however, moderate to substantial agreement was observed for categorical data, and the SASDAS classified a lower proportion of patients as being in the inactive and low disease activity categories.
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome
Authors: Taylor Maria L. , Hoyt Kacie J. , Han Joseph , Benson Leslie , Case Siobhan , Chandler Mia T. , Chang Margaret H. , Platt Craig , Cohen Ezra M. , Day-Lewis Megan , Dedeoglu Fatma , Gorman Mark , Hausmann Jonathan S. , Janssen Erin , Lee Pui Y. , Lo Jeffrey , Priebe Gregory P. , Lo Mindy S. , Meidan Esra , Nigrovic Peter A. , Roberts Jordan E. , Son Mary Beth F. , Sundel Robert P. , Alfieri Maria , Yeun Jenny Chan , Shobiye Damilola M. , Degar Barbara , Chang Joyce C. , Halyabar Olha , Hazen Melissa M. , Henderson Lauren A. 
Published: July 2022

ObjectiveTo compare clinical outcomes in children with hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) who were managed before and after implementation of an evidence-based guideline (EBG).MethodsA management algorithm for MAS-HLH was developed at our institution based on literature review, expert opinion, and consensus building across multiple pediatric subspecialties. An electronic medical record search retrospectively identified hospitalized patients with MAS-HLH in the pre-EBG (October 15, 2015, to December 4, 2017) and post-EBG (January 1, 2018, to January 21, 2020) time periods. Predetermined outcome metrics were evaluated in the 2 cohorts.ResultsAfter the EBG launch, 57 children were identified by house staff as potential patients with MAS-HLH, and rheumatology was consulted for management. Ultimately, 17 patients were diagnosed with MAS-HLH by the treating team. Of these, 59% met HLH 2004 criteria, and 94% met 2016 classification criteria for MAS complicating systemic juvenile idiopathic arthritis. There was a statistically significant reduction in mortality from 50% before implementation of the EBG to 6% in the post-EBG cohort (P = 0.02). There was a significant improvement in time to 50% reduction in C-reactive protein level in the post-EBG vs pre-EBG cohorts (log-rank P < 0.01). There were trends toward faster time to MAS-HLH diagnosis, faster initiation of immunosuppressive therapy, shorter length of hospital stay, and more rapid normalization of MAS-HLH–related biomarkers in the patients post-EBG.ConclusionWhile the observed improvements may be partially attributed to advances in treatment of MAS-HLH that have accumulated over time, this analysis also suggests that a multidisciplinary treatment pathway for MAS-HLH contributed meaningfully to favorable patient outcomes.
Relationship Between Inflammation and Radiographic Progression in Patients With Ankylosing Spondylitis Attaining a BASDAI of Less Than 4 During Tumor Necrosis Factor Inhibitor Treatment
Authors: Koo Bon San , Oh Ji Seon , Park Seo Young , Shin Ji Hui , Nam Bora , Lee Seunghun , Joo Kyung Bin , Kim Tae-Hwan 
Published: July 2022

ObjectiveTo determine the relationship between inflammation and radiographic progression over time in patients with ankylosing spondylitis (AS) attaining a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) of < 4 during tumor necrosis factor inhibitor (TNFi) treatment.MethodsMedical records data of patients with AS with BASDAI scores of < 4 during TNFi treatment were analyzed at 6-month intervals from January 2001 to December 2018. To determine the relationship between the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) and C-reactive protein (CRP) over time, we fitted linear mixed models with mSASSS as the response variable, baseline mSASSS and the cumulative sum of CRP with different lag times (6, 12, 18, 24, 30, and 36 months) as fixed effects, and patients as random effects. Associations between mSASSS and the cumulative sum of CRP, or the lag times with the highest beta coefficients, were further investigated with linear mixed models that included additional clinical variables.ResultsA total of 2956 intervals were obtained from 333 patients. Among different lag times, the cumulative sum of log CRP in the previous 18 to 36 months associated with mSASSS showed significant beta coefficients. In the final linear mixed model, the cumulative sum of log CRP in the previous 24 months was significantly associated with mSASSS at 24 months (β 0.04, 95% CI 0.01-0.07,P= 0.004).ConclusionRemnant inflammation correlates with radiographic progression, even in patients attaining a BASDAI of < 4 during TNFi treatment. CRP is a surrogate marker for radiographic progression despite clinical improvement with TNFi treatment.
Canadian Rheumatology Association Living Guidelines for the Pharmacological Management of Rheumatoid Arthritis With Disease-Modifying Antirheumatic Drugs
Authors: Hazlewood Glen S. , Pardo Jordi Pardo , Barnabe Cheryl , Schieir Orit , Barber Claire E.H. , Proulx Laurie , Richards Dawn P. , Tugwell Peter , Bansback Nick , Akhavan Pooneh , Bombardier Claire , Bykerk Vivian , Jamal Shahin , Khraishi Majed , Taylor-Gjevre Regina , Thorne J. Carter , Agarwal Arnav , Pope Janet E. 
Published: July 2022

ObjectiveTo provide the initial installment of a living guideline that will provide up-to-date guidance on the pharmacological management of patients with rheumatoid arthritis (RA) in Canada.MethodsThe Canadian Rheumatology Association (CRA) formed a multidisciplinary panel composed of rheumatologists, researchers, methodologists, and patients. In this first installment of our living guideline, the panel developed a recommendation for the tapering of biologic and targeted synthetic disease-modifying antirheumatic drug (b/ts DMARD) therapy in patients in sustained remission using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach, including a health equity framework developed for the Canadian RA population. The recommendation was adapted from a living guideline of the Australia & New Zealand Musculoskeletal Clinical Trials Network.ResultsIn people with RA who are in sustained low disease activity or remission for at least 6 months, we suggest offering stepwise reduction in the dose of b/tsDMARD without discontinuation, in the context of a shared decision, provided patients are able to rapidly access rheumatology care and reestablish their medications if needed. In patients where rapid access to care or reestablishing access to medications is challenging, we conditionally recommend against tapering. A patient decision aid was developed to complement the recommendation.ConclusionThis living guideline will provide contemporary RA management recommendations for Canadian practice. New recommendations will be added over time and updated, with the latest recommendation, evidence summaries, and Evidence to Decision summaries available through the CRA website (www.rheum.ca).
Patterns in the relationship between acute COVID-19/long COVID-19 and quality of life
Authors: Tüzün Hakan , Özbaş Cansu , Budak Burkay , Altunay Gizem , Aksakal F. N. Baran 
Published: July 2022

Objective:
To determine the change in the quality of life (QoL) of patients who applied to a tertiary outpatient clinic according to their COVID-19 status.

Methods:
This cross-sectional study comprised 1 370 participants. Short form-12 (SF-12), which includes Physical Component Summary (PCS) and Mental Component Summary (MCS) domains, was used to evaluate the QoL. Different linear regression models created using PCS-12 and MCS-12 were dependent variables.

Results:
A total of 19.2% of participants had acute COVID-19, and 8.4% had long COVID-19. The most common sypmtoms were fatigue (72.6%), headache (42.5%), and joint pain (39.8%) in patients with long COVID-19. The model including all participants showed that long COVID-19 reduced the QoL in multivariate analysis for both MCS and PCS, while acute COVID-19 had no significant effect on the QoL comparing with those without COVID-19. Model that included participants with COVID-19 showed that long COVID-19 negatively affected the QoL in the multivariate model for PCS-12 and MCS-12. Variables that were significant in the multivariate model for those who had long COVID-19 were having a chronic disease and presence of ongoing symptoms. Females were disadvantaged for PCS-12 and MCS-12 in the multivariate models including all participants, and models including participants who have had COVID-19. Low educational group were disadvantaged for PCS-12 in the multivariate model including all participants. This group were also disadvantaged for PCS-12 and MCS-12 in the multivariate models including participants who had COVID-19.

Conclusions:
In studies, acute COVID-19 and long COVID-19 should be treated as separate categories. The effects of long COVID-19 should be considered when providing and planning health services. The effect of gender, and education, on QoL shows that health inequalities continue to be effective during the pandemic period.
Disseminated histoplasmosis in a 17-year-old Nigerian male patient
Authors: Ewa Atana Uket , Ekeng Bassey Ewa , Bassey Glory Ekpo , Akpah Enobong Ufot , Asemota Osamagbe Aiyudubie , Nweke Livinus Nwancho 
Published: July 2022

Rationale:
Disseminated histoplasmosis is the most severe form of histoplasmosis and often associated with fatal outcomes. Both pulmonary and disseminated forms mimics tuberculosis (TB) and may be misdiagnosed.

Patient concerns:
A 17-year-old male patient compliant with anti- tuberculosis therapy with complaints of fever, cough productive of thick yellowish sputum, fast breathing, abdominal pain, swelling and jaundice. HIV status was negative.

Diagnosis:
Disseminated histoplasmosis.

Interventions:
Antimicrobials including anti-TB therapy, ceftriaxone, gentamicin, azithromycin and ciprofloxacin.

Outcomes:
He was responding to anti-TB drugs until about 4 and a half months on treatment when he fell ill. Peripheral blood film done 2 days prior to his demise revealed florid yeast like organisms in monocytes with eccentric chromatin suggestive of Histoplasma capsulatum.

Lessons:
Histoplasmosis can both mimic and coexist with TB and so a high index of suspicion is needed for its diagnosis.
Spectrum of Movement Disorder Emergencies in a Tertiary Care Center in India
Authors: Bhoyar Abhishek P. , Mahale Rohan , Kamble Nitish , Holla Vikram , Pal Pramod Kumar , Yadav Ravi 
Published: July 2022

Introduction:
Movement disorders can present in emergency services in an acute severe form which can be life threatening if not recognized. The relative frequency and spectrum of movement disorder emergencies have not been studied extensively. We studied the frequency, spectrum, and outcome of patients presenting with movement disorders emergencies.

Methods:
This was a prospective, descriptive single center study. Patients presenting with acute movement disorders to the neurology emergency services of the institute during the study period from April 2019 to June 2021 were analyzed.

Results:
A total of 71 patients presented with acute movement disorders during the study period. Out of them, 65 patients had hyperkinetic and 6 patients had hypokinetic movement disorders emergencies. Fifteen patients were below the age of 18 years. Chorea (59.1%) was the most common movement disorder emergencies followed by dystonia and myoclonus in adults. Dystonia (33.3%) was the common movement disorder emergencies in children. Hyperglycemia followed by stroke was the most common etiology of acute movement disorders.

Conclusion:
This study brings out some novel findings on the movement disorders emergencies in Indian scenario. Chorea was the most common movement disorder emergencies presenting to the neurology emergency services. Early recognition and management of movement disorders emergencies help in reducing morbidity.
Bedside Reduction of Gastroschisis: A Preliminary Experience in Yaounde-Cameroon
Authors: Tambo Faustin Felicien Mouafo , Badjang Gaelle Therese , Kamga Gacelle Fossi , Sadjo Salihou Aminou , Tsala Irene Nadine Kouna , Ondobo Gervais Andze , Sosso Maurice Aurélien 
Published: July 2022

Background:
Gastroschisis denotes a congenital or sporadic malformation of the anterior abdominal wall, which is rarely associated with other anomalies. The mortality in African countries is still high almost 100%.

Objective:
The aim was to determine the feasibility and safety of bedside reduction of gastroschisis and factors affecting the outcome in low-income setting.

Methodology:
This was a retrospective, descriptive and analytic study over a period of 6 years conducted in the Pediatric Surgery Service of the Yaoundé Gyneco-Obstetric and Pediatric Hospital. Only neonates with gastroschisis seen within 6 h of life without bowel necrosis and in whom bedside reduction was attempted in the neonatology unit under sedation (with 0.5 mg/kg of diazepam intra-rectally and 0.5–1 mg of atropine intravenously) were included in this study. Ethical clearance was obtained for the Ethical Committee of the Yaoundé Gyneco-Obstetric and Pediatric Hospital and a signed consent form was required from the parents of the children prior to the procedure.

Results:
Twelve neonates with a mean age of 16.8 h (0 and 24 h) and mean birth weight of 2245 g (1860–3600 g) were enrolled. The mean time to presentation at hospital was 3.5 h (2–9 h). Bedside closure was successful in 10 patients. Two patients underwent primary closure in the theatre after failure of bedside reduction due to the volume of contents of gastroschisis. Mortality rate in our study was 33.3% and the morbidity was dominated by compartment syndrome and malnutrition.

Conclusion:
Bedside reduction of gastroschisis under sedation in Yaoundé seems to be way to reduce the mortality.