bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction Skill of GEFSv12 in Depicting Monthly Rainfall and Associated Extreme Events over Taiwan during the Summer Monsoon
Authors: Nageswararao M. M. , Zhu Yuejian , Tallapragada Vijay , Chen Meng-Shih 
Published: September 2022

Abstract
The skillful prediction of monthly scale rainfall in small regions like Taiwan is one of the challenges of the meteorological scientific community. Taiwan is one of the subtropical islands in Asia. It experiences rainfall extremes regularly, leading to landslides and flash floods in/near the mountains and flooding over low-lying plains, particularly during the summer monsoon season [June–September (JJAS)]. In September 2020, NOAA/NCEP implemented Global Ensemble Forecast System, version 12 (GEFSv12), to support stakeholders for subseasonal forecasts and hydrological applications. In the present study, the performance evaluation of GEFSv12 for monthly rainfall and associated extreme rainfall (ER) events over Taiwan during JJAS against CMORPH has been done. There is a marginal improvement of GEFSv12 in depicting the East Asian summer monsoon index (EASMI) as compared to GEFS-SubX. The GEFSv12 rainfall raw products have been calibrated with a quantile–quantile (QQ) mapping technique for further prediction skill improvement. The results reveal that the spatial patterns of climatological features (mean, interannual variability, and coefficient of variation) of summer monsoon monthly rainfall over Taiwan from QQ-GEFSv12 are very similar to CMORPH than Raw-GEFSv12. Raw-GEFSv12 has an enormous wet bias and overforecast wet days, while QQ-GEFSv12 is close to reality. The prediction skill (correlation coefficient and index of agreement) of GEFSv12 in depicting the summer monsoon monthly rainfall over Taiwan is significantly high (>0.5) in most parts of Taiwan and particularly more during peak monsoon months, September, and August, followed by June and July. The calibration method significantly reduces the overestimation (underestimation) of wet (ER) events from the ensemble mean and probabilistic ensemble forecasts. The predictability of extreme rainfall events (>50 mm day−1) has also improved significantly.
Explaining the Relation Between Perceived Social Support and Psychological Well-Being Among Chinese Nursing Students: A Serial Multiple Mediator Model Involving Integrative Self-Knowledge and Self-Integrity
Authors: Zhou Lu , Cai EnLi , Thitinan Chankoson , Khunanan Sukpasjaroen , Wu YuMing , Liu Gao 
Published: September 2022

Background Addressing numerous calls for understanding the theoretical mechanisms that explain the relationship between perceived social support and psychological well-being to enhance nursing students’ mental health. Aims This study focused on how integrative self-knowledge and self-integrity mediate the relationship between perceived social support and psychological well-being. Methods The Structural Equation Model (SEM) was used to estimate the mediation effects on the relationship between perceived social support and psychological well-being among 487 undergraduate nursing students. To examine the directionality of effects, the present study also tested the reverse serial mediation model. Multi-group SEM (MGSEM) was used to test gender differences in the mediation model. Results Integrative self-knowledge and self-integrity, in sequence, mediated the association between perceived social support and psychological well-being among nursing students. In addition, there was no gender difference in these associations. Conclusions Improving nursing students’ perceived social support, integrative self-knowledge, and self-integrity is beneficial for promoting their mental health.
CtDNA-guided rechallenge with anti-EGFR therapy in RASwt metastatic colorectal cancer: Evidence from clinical practice
Authors: D’Onofrio Raffaella , Caputo Francesco , Prampolini Francesco , Spallanzani Andrea , Gelsomino Fabio , Bettelli Stefania , Manfredini Samantha , Reggiani Bonetti Luca , Carotenuto Pietro , Bocconi Alessandro , Dominici Massimo , Luppi Gabriele , Salati Massimiliano 
Published: September 2022

Aim: To apply extended ctDNA-based RAS genotyping to clinical criteria for improving the selection of patients eligible for anti-EGFR-based rechallenge in a real-world setting. Methods: ctDNA testing was prospectively applied to RASwt mCRC progressed after a first-line anti-EGFR-containing regimen and at least one other line. The primary endpoint was the objective response rate. Results: Among ten enrolled patients, the anti-EGFR rechallenge resulted in an objective response rate and disease control rate of 70% and 90%. The median progression-free survival was 11.3 months and overall survival was not reached. Compared with a historical cohort retreated with anti-EGFR agents based on clinical criteria, the ctDNA-driven approach resulted in a higher chance of achieving an objective response and longer survival. Conclusions: Blood-based RASwt status may enrich metastatic colorectal cancer more likely to benefit from anti-EGFR-based rechallenge. RAS genotyping in ctDNA represents a feasible, fast, and cost-effective tool to be implemented in the clinic for advancing precision medicine.
Exploring Relationships Between State-Level LGBTQ Inclusivity and BRFSS Indicators of Mental Health and Risk Behaviors: A Secondary Analysis
Authors: White Bradley Patrick , Abuelezam Nadia N. , Fontenot Holly B. , Jurgens Corrine Y. 
Published: September 2022

Objectives: Minority Stress Theory suggests that repeated exposure to enacted stigma adversely affects mental health. States have wide authority to enact policies affecting the level of inclusivity experienced by lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) residents. The purpose of this study was to explore relationships between states’ level of LGBTQ inclusivity and indicators of mental health/risk behaviors among an LGBTQ sample. Methods: The 2018 Human Rights Campaign State Equality Index (SEI) and the 2018 Behavioral Risk Factor Surveillance Survey (BRFSS) were used to examine relationships between states’ levels of LGBTQ inclusivity (predictor variable) and indicators of mental health/risk behaviors (outcome variables). Relationships were explored using descriptive statistics and survey-weighted logistic regression. Results: Lower state inclusivity increased odds of fair/poor general health (adjusted odds ratio [AOR]: 1.22, 95% confidence interval [CI]: 1.01–1.48), increased odds of poor mental health days (AOR: 1.34, 95% CI: 1.11–1.62), increased odds of smoking (AOR: 1.62, 95% CI: 1.27–2.07), and increased odds of heavy drinking (AOR: 1.54, 95% CI: 1.26–1.86) and binge drinking (AOR: 1.23, 95% CI: 1.01–1.49). State inclusivity did not influence odds of a depressive disorder diagnosis or driving under the influence of alcohol. Conclusions: LGBTQ persons in restrictive states had increased odds of experiencing several indicators of mental health and risk behaviors. More research is needed to determine whether state policies affect other domains of LGBTQ persons’ health. Health care providers should be mindful of LGBTQ persons’ mental health/risk behaviors and the state policy environment, and should seek to implement mitigating health care strategies such as the use of validated assessment.
The effect of nonsupervised physical activity before and after breast cancer surgery on quality of life: Results from a randomized controlled trial (PhysSURG-B)
Authors: Heiman Jenny , Onerup Aron , Bock David , Haglind Eva , Olofsson Bagge Roger 
Published: September 2022

Background and objective: The PhysSURG-B trial of prehabilitation before breast cancer surgery randomized patients to a nonsupervised physical activity or a control group. The effects of the intervention on short- and long-term quality of life (QoL) were examined, with a subgroup analysis of patients receiving adjuvant chemotherapy. Methods: Female patients planned for surgery were randomly assigned to either an intervention of 30 min of self-administered physical aerobic activity daily 2 weeks before and 4 weeks after surgery or control. QoL was assessed with questionnaires at baseline, 4 weeks and 12 months postoperatively using the instruments FACT-B, RAND-36, and EQ-VAS. Results: Of 354 included participants at 12 months after surgery, 287 were available for analysis. FACT- B scores at 4 weeks and 12 months showed no differences between intervention compared to control, odds ratio (OR) of 0.975 (95% confidence interval (CI) 0.636–1.495) and 0.883 (95% CI 0.581–1.342), respectively. There was no difference in EQ-VAS comparing intervention to control at 4 weeks and 12 months, respectively, OR 1.163 (95% CI 0.760–1.779) and 0.817 (95% CI 0.559–1.300). RAND-36 domains “role limitations due to physical health” and “pain” showed a decrease at 4 weeks in both groups, returning toward baseline at 12 months follow-up. The subgroup who received adjuvant chemotherapy had significantly lower QoL measured using FACT-B at 12 months compared to patients not receiving chemotherapy (OR 0.475; 95% CI 0.300–0.753). Conclusions: An intervention of non-supervised physical activity before and after surgery for breast cancer showed no effect on short or long-term QoL, compared to control. Trial registration: ClinicalTrials.gov registration number: NCT 02560662.
Impact of an Outpatient Fracture Liaison Service on Osteoporosis Evaluation Among Patients With Upper Extremity Fragility Fracture
Authors: Seyok Thany , Collins Jamie E. , Erikson Samantha J. , Charles Julia F. , Earp Brandon E. 
Published: September 2022

Background: The purpose of this study was to assess the impact of implementation of an outpatient fracture liaison service (FLS) on completion rates of dual-energy x-ray absorptiometry (DXA) and screening labs including 25-OH vitamin D and parathyroid hormone (PTH) in patients with upper extremity (UE) fragility fractures. Methods: At our institution, 367 patients were treated in 2014-2015 for UE fragility fractures of the distal radius and proximal humerus before implementation of our outpatient FLS and 395 patients in 2017-2018 after implementation. Retrospective chart review was conducted to identify completed DXA scans within 2 years of fracture treatment and completed 25-OH vitamin D and PTH labs within 1 year of fracture treatment. Results: There were no statistical differences in the demographics of patients treated for distal radial and proximal humeral fragility fractures during the 2014-2015 and 2017-2018 time periods. Implementation of the FLS resulted in a 9.9% increase ( P value = .021) in completed DXA scans within 2 years of fracture treatment. Completed 25-OH vitamin D and PTH labs saw a significant increase of 17.1% and 23.8%, respectively ( P values < .001). Conclusions: Implementation of an outpatient FLS can help to improve osteoporosis evaluation with completed DXA scans and 25-OH vitamin D and PTH labs.
Dose-dependent Action of Zingiber officinale on Colonic Dysmotility and Ex Vivo Spontaneous Intestinal Contraction Modulation
Authors: Abidi Chaima , Rtibi Kais , Boutahiri Salima , Tounsi Haifa , Abdellaoui Afifa , Wahabi Soumaya , Gressier Bernard , Eto Bruno , Sebai Hichem 
Published: September 2022

Ginger ( Zingiber officinale) rhizomes are commonly used in foods and employed for many ailments including gastrointestinal disorders. Our main objective was to evaluate the effect of Zingiber officinale aqueous extract (ZOAE) on gastrointestinal (GI) physiological motility and colonic dysmotility. Thereby, Wistar rats were given loperamide (LP, 3 mg/kg, b.w.) and ZOAE (75, 150, and 300 mg/kg, b.w.) or yohimbine (YOH, 2 mg/kg, b.w.). ZOAE-action on intestinal secretion was assessed using Ussing chamber technique and intestinal motility with isometric transducer. GI-transit (GIT) and gastric emptying (GE) were evaluated with the charcoal meal test and the red phenol methods. ZOAE-bioactive components were analyzed by liquid chromatography-high resolution electrospray ionization mass spectrometry (LC-HRESIMS). Constipation was induced with LP and the different indicators such as stool composition, GIT, oxidative stress biological parameters, and colonic mucosa histological alteration were performed. Anti-constipation effect of ZOAE was confirmed on stool composition, GIT (53.42% to 85.57%), GE (55.47% to 98.88%), and re-established oxidative balance. ZOAE induces an amplitude increase of spontaneous intestinal contraction with EC50 of 10.52 μg/mL. No effect of ZOAE was observed on electrogenic transport of intestinal fluid. These findings suggest that ZOAE-bioactive candidates might exert an anti-constipation action and spontaneous intestinal contraction modulation.
What are nurses’ roles in modern healthcare? A qualitative interview study using interpretive description
Authors: Jackson Jennifer , Maben Jill , Anderson Janet E 
Published: September 2022

Aim Nursing work has historically been difficult to specify. This has led to difficulties in determining safe staffing requirements and adequately supporting safe patient care. The aim of this qualitative interview study was to explore how nurses understand their work. Design Qualitative interview study, using the interpretive description methodology. Methods Twenty registered nurses and nursing students completed semi-structured interviews about their work. The researcher drew on the interpretive description methodology to analyse interview data and create a model that interprets participants’ experiences of their nursing work. Results Nurses understand their work by its role in the healthcare system, rather than by the tasks or activities they complete. This understanding is significant because nurses adapt their work constantly, and rigid definitions of working would not support safe adaptation. Nurses report working across three broad roles: clinical work, which is patient-facing; managing work, which sustains the care environment; and enabling work, which provides supports like research and education that make nursing a profession. Conclusions Clinical, managing and enabling work have different aims, but all serve the purpose of supporting safe patient care and sustaining healthcare systems. Adaptation is a constant feature of each of these roles. This model may be useful for nurses in structuring and explaining their work and informing nursing workforce policy.
Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study
Authors: Skajaa Nils , Vandenbroucke Jan P. , Simonsen Claus Ziegler , Sørensen Henrik Toft , Adelborg Kasper 
Published: September 2022

Abstract
Cerebral venous thrombosis (CVT) predominantly affects young to middle-aged women. Scarce data exist regarding the long-term prognosis. We examined the clinical course of patients with CVT overall and according to their age and sex. Using Danish registries, we identified all patients with a first-time primary inpatient diagnosis of CVT from 1996-2018 (N = 653; median age, 41 years; 67% women) and individuals from the general population matched for age, sex, and calendar year (N = 65 300). Patients with CVT were at an increased risk of venous thromboembolism (VTE) at other sites, ischemic stroke, major bleeding, and mortality. For both sexes, the increased risks of VTE at other sites were most prominent among younger patients (18-54 years), whereas the increased risks of ischemic stroke, major bleeding, and mortality were most prominent among older patients (≥55 years). Among young women, the 10-year risks of VTE at other sites for patients with CVT compared with members of the matched cohort were 2.2% vs 0.4% (risk difference, 1.8%; 95% confidence interval [CI], 0.0-3.6). Among older women, compared with members of the matched cohort, the 10-year risks were 12.8% vs 3.1% (risk difference, 9.7%; 95% CI, 1.6-17.9) for ischemic stroke, 11.1% vs 4.6% (risk difference, 6.5%; 95% CI, −1.0 to 14.1) for major bleeding, and 43.1% vs 26.7% (risk difference, 16.4%; 95% CI, 3.7-29.1) for all-cause mortality. The risk of myocardial infarction was not elevated. Clinicians should be aware of the importance of age and sex heterogeneity in the prognosis of CVT.
Boolean implication analysis of single-cell data predicts retinal cell type markers
Authors: Subramanian Rohan , Sahoo Debashis 
Published: September 2022

AbstractBackgroundThe retina is a complex tissue containing multiple cell types that are essential for vision. Understanding the gene expression patterns of various retinal cell types has potential applications in regenerative medicine. Retinal organoids (optic vesicles) derived from pluripotent stem cells have begun to yield insights into the transcriptomics of developing retinal cell types in humans through single cell RNA-sequencing studies. Previous methods of gene reporting have relied upon techniques in vivo using microarray data, or correlational and dimension reduction methods for analyzing single cell RNA-sequencing data computationally. We aimed to develop a state-of-the-art Boolean method that filtered out noise, could be applied to a wide variety of datasets and lent insight into gene expression over differentiation.ResultsHere, we present a bioinformatic approach using Boolean implication to discover genes which are retinal cell type-specific or involved in retinal cell fate. We apply this approach to previously published retina and retinal organoid datasets and improve upon previously published correlational methods. Our method improves the prediction accuracy of marker genes of retinal cell types and discovers several new high confidence cone and rod-specific genes.ConclusionsThe results of this study demonstrate the benefits of a Boolean approach that considers asymmetric relationships. We have shown a statistically significant improvement from correlational, symmetric methods in the prediction accuracy of retinal cell-type specific genes.Furthermore, our method contains no cell or tissue-specific tuning and hence could impact other areas of gene expression analyses in cancer and other human diseases.
Neuroanatomical regions associated with non-progressive dysarthria post-stroke: a systematic review
Authors: Summaka Marwa , Hannoun Salem , Harati Hayat , Daoud Rama , Zein Hiba , Estephan Elias , Naim Ibrahim , Nasser Zeina 
Published: September 2022

Abstract
Background
Dysarthria is a common and persisting sequela to stroke. It can have a negative influence on psychological wellbeing, and quality of life. This systematic review aimed to describe and identify the neuroanatomical regions associated with non-progressive dysarthria following stroke.

Methods
A systematic search of PubMed, Ovid Medline, CINAHL, Cochrane, Scopus, and ScienceDirect was conducted to identify all relevant articles published in peer-reviewed journals up to December 2021. Following data extraction, the National Institutes of Health (NIH) quality assessment tools were used to evaluate the methodological quality of the included studies.

Results
Out of 2186 papers found in the literature related to dysarthria post-stroke, 24 met the inclusion criteria. Eligible articles assessed 1150 post-stroke subjects. Out of them, 420 subjects had dysarthria from isolated lesions. Regarding dysarthric subjects with ischemic strokes, 153 sustained supratentorial infarctions, while 267 had infratentorial infarctions. The majority had pontine infarctions (n = 142), followed by infarctions in the corona radiata (n = 104), and the cerebellum (n = 64).

Conclusion
This systematic review is the first step toward establishing a neuroanatomical model of dysarthria throughout the whole brain. Our findings have many implications for clinical practice and provide a framework for implementing guidelines for early detection and management of dysarthria post-stroke.
Morphology and composition of the ventral neck muscles in individuals with chronic whiplash related disorders compared to matched healthy controls: a cross-sectional case–control study
Authors: Peolsson Anneli , Karlsson Anette , Peterson Gunnel , Borén Hanna , Zsigmond Peter , Elliott James M. , Leinhard Olof Dahlqvist 
Published: September 2022

Abstract
Background

Objective
Studies of cross-sectional area (CSA) (morphology) and muscle fat infiltration (MFI) (composition) in ventral neck muscles is scarce in patients with chronic whiplash associated disorders (WAD), especially for men and those with severe WAD compared with matched healthy controls. The aim was to compare CSA and MFI of sternocleidomastoid (SCM), longus capitis (LCA) and longus colli (LCO) in patients with chronic right-sided dominant moderate (Neck Disability Index: NDI < 40) or severe WAD (NDI ≥ 40), compared to age- and sex-matched healthy controls.

Methods
Cross-sectional case–control study with blinded investigators. Thirty-one patients with chronic WAD (17 women and 14 men, mean age 40 years) (SD 12.6, range 20–62)) and 31 age- and sex-matched healthy controls underwent magnetic resonance imaging of ventral neck muscles segmental level C4.

Results
Unique to the severe group was a larger magnitude of MFI in right SCM (p = 0.02) compared with healthy controls. There was no significant difference between the groups with regards to the other muscles and measures.

Conclusions
Individuals with severe right-sided dominant WAD have a higher MFI in the right SCM compared to healthy controls. No other differences were found between the groups. The present study indicates that there are changes in the composition of muscles on the side of greatest pain.
The role of companion animals in advanced cancer: an interpretative phenomenological analysis
Authors: McGhee William R. G. , Dempster Martin , Graham-Wisener Lisa 
Published: September 2022

Abstract
Background
There is evidence that a companion animal (CA) or ‘pet’ can be helpful during the management of chronic illness. However, the psychological effects of CAs and the mechanism by which they can be beneficial to individuals managing life-limiting conditions is unknown. This study addresses this gap and provides the first examination of the lived experience of CAs among community-dwelling adults with advanced cancer.

Methods
Semi-structured qualitative interview study consisting of a homogenous sample of 6 individuals with an advanced cancer diagnosis, who either self-selected to the study or were recruited through a regional charity that supports palliative and end-of-life care patients in maintaining a connection with their CA. Data were transcribed verbatim and analysed using Interpretative Phenomenological Analysis.

Results
Four superordinate themes occurred in the data: a protective relationship, positive behavioural change, facilitating meaningful social connections and increased loss-orientated cognitions. The findings suggest that CAs offer de-arousing and socially protective supports that mitigate physical and psychological sequalae experienced by people with advanced cancer. However, as their illness progresses, individuals may also experience thoughts related to not meeting their CA’s needs currently and in the future.

Conclusions
CAs provide emotional, practical, and social supports to individuals diagnosed with advanced cancer that can improve individual psychological wellbeing. Consequently, it is important that CAs are considered in advance care planning processes and that services are available to mitigate any negative effects of CA ownership, in order to maximise the benefits CAs confer to individuals managing advanced cancer.