bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Perceptions of Corruption Matching Experience? Evidence from Microdata
Authors: Corrado Germana , Corrado Luisa , De Michele Giuseppe , Salustri Francesco 
Published: April 2022

Abstract
The efficacy of corruption perception indices to truly capture and accurately measure corruption behaviours has been often criticised. In fact, perceptions about corruption may not match actual experience and could represent distorted beliefs. Motivated by this criticism, we investigate the difference between perceived and experienced corruption (i.e., bribery) in public services in Europe by means of a theoretical model and an empirical analysis. Firstly, we model perceived corruption as a function of experienced corruption and a perception bias. Then, we employ a generalised setting of structural equation models to derive two distinct measures of perceived and experienced corruption from microdata on the public administration sector in Europe. The indices we obtain allow us to compare countries according to both measures of public corruption. Finally, our results suggest that perceptions of corruption may be affected by sources of media bias.
A comparison between thoracic epidural analgesia and rectus sheath catheter analgesia after open midline major abdominal surgery: randomized clinical trial
Authors: Krige Anton , Brearley Sarah G. , Mateus Céu , Carlson Gordon L. , Lane Steven 
Published: April 2022

Abstract

Background
Rectus sheath catheter analgesia (RSCA) and thoracic epidural analgesia (TEA) are both used for analgesia following laparotomy. The aim was to compare the analgesic effectiveness of RSCA with TEA after laparotomy for elective colorectal and urological surgery.

Methods
Patients undergoing elective midline laparotomy were randomized in a non-blinded fashion to receive RSCA or TEA for postoperative analgesia at a single UK teaching hospital. The primary quantitative outcome measure was dynamic pain score at 24 h after surgery. A nested qualitative study (reported elsewhere) explored the dual primary outcome of patient experience and acceptability. Secondary outcome measures included rest and movement pain scores over 72 h, functional analgesia, analgesia satisfaction, opiate consumption, functional recovery, morbidity, safety, and cost-effectiveness.

Results
A total of 131 patients were randomized: 66 in the RSCA group and 65 in the TEA group. The median (interquartile range; i.q.r.) dynamic pain score at 24 h was significantly lower after TEA than RSCA (33 (11–60) versus 50.5 (24.50–77.25); P = 0.018). Resting pain score at 72 h was significantly lower after RSCA (4.5 (0.25–13.75) versus 12.5 (2–13); P = 0.019). Opiate consumption on postoperative day 3 (median (i.q.r.) morphine equivalent 17 (10–30) mg versus 40 (13.25–88.50) mg; P = 0.038), hypotension, or vasopressor dependency (29.7 versus 49.2 per cent; P = 0.023) and weight gain to day 3 (median (i.q.r.) 0 (−1–2) kg versus 1 (0–3) kg; P = 0.046) were all significantly greater after TEA, compared with RSCA. There were no significant differences between groups in other secondary outcomes, although more participants experienced serious adverse events after TEA compared with RSCA, which was also the more cost-effective.

Conclusions
TEA provided superior initial postoperative analgesia but only for the first 24 h. By 72 hours RSCA provides superior analgesia, is associated with a lower incidence of unwanted effects, and may be more cost-effective.
Effect of local anaesthetic infiltration on postoperative pain after laparoscopic cholecystectomy: randomized clinical trial
Authors: Suragul Wikran , Tantawanit Apawee , Rungsakulkij Narongsak , Muangkaew Paramin , Tangtawee Pongsatorn , Mingphrudhi Somkit , Vassanasiri Watoo , Lertsithichai Panuwat , Aeesoa Suraida , Apinyachon Worapot 
Published: April 2022

Abstract

Background
Local anaesthetic infiltration is widely used to reduce pain after laparoscopic cholecystectomy (LC). This trial evaluated the effect of depth of local anaesthetic infiltration on postoperative pain reduction after LC.

Methods
Patients undergoing elective LC between March 2018 and February 2019 were randomized into no infiltration, subcutaneous infiltration, and rectus sheath infiltration using bupivacaine. The primary outcome was 24-h postoperative cumulative morphine use, and the secondary outcomes were mean 24-h Numerical Rating Scale (NRS) for pain, and nausea, and vomiting. Subgroups were compared and multivariable analyses were performed.

Results
Out of 170 eligible patients, 162 were selected and 150 patients were analysed: 48 in the no-infiltration group, 50 in the subcutaneous infiltration group, and 52 in the rectus sheath infiltration group. The groups had similar clinical features, although mean BMI was higher in the subcutaneous infiltration group (P = 0.001). The 24-h cumulative morphine use in the rectus sheath infiltration group was significantly lower than in the no-infiltration group (P = 0.043), but no difference was observed between the subcutaneous infiltration and no-infiltration groups (P = 0.999). One hour after surgery, the rectus sheath infiltration group had a significantly lower NRS score than the no-infiltration and subcutaneous infiltration groups respectively (P = 0.006 and P = 0.031); however, the score did not differ among the three groups at any of the time points from 2 h after the surgery. The incidence of nausea or vomiting was comparable among the three groups. Multivariable analysis documented that a lower dose of morphine use was associated with rectus sheath infiltration (P = 0.004) and diabetes (P = 0.001); whereas, increased morphine use was associate with age (P = 0.040) and a longer duration of surgery (P = 0.007).

Conclusions
Local anaesthetic infiltration into the rectus sheath reduced postoperative cumulative morphine use and the immediate NRS score in patients undergoing LC; however, the pain scores were comparable 2 h after surgery.

Registration number
TCTR20201103002 (http://www.thaiclinicaltrials.org).
Sleep loss disrupts the neural signature of successful learning
Authors: Guttesen Anna á V , Gaskell M Gareth , Madden Emily V , Appleby Gabrielle , Cross Zachariah R , Cairney Scott A 
Published: April 2022

AbstractSleep supports memory consolidation as well as next-day learning. The influential “Active Systems” account of offline consolidation suggests that sleep-associated memory processing paves the way for new learning, but empirical evidence in support of this idea is scarce. Using a within-subjects (n = 30), crossover design, we assessed behavioral and electrophysiological indices of episodic encoding after a night of sleep or total sleep deprivation in healthy adults (aged 18–25 years) and investigated whether behavioral performance was predicted by the overnight consolidation of episodic associations from the previous day. Sleep supported memory consolidation and next-day learning as compared to sleep deprivation. However, the magnitude of this sleep-associated consolidation benefit did not significantly predict the ability to form novel memories after sleep. Interestingly, sleep deprivation prompted a qualitative change in the neural signature of encoding: Whereas 12–20 Hz beta desynchronization—an established marker of successful encoding—was observed after sleep, sleep deprivation disrupted beta desynchrony during successful learning. Taken together, these findings suggest that effective learning depends on sleep but not necessarily on sleep-associated consolidation.
Gender effects on the controllability of hemispheric white matter networks
Authors: Li Dandan , Mao Min , Zhang Xi , Hou Dianni , Zhang Shanshan , Hao Jiangping , Cui Xiaohong , Niu Yan , Xiang Jie , Wang Bin 
Published: April 2022

AbstractMale and female adults exhibited significant group differences in brain white matter (WM) asymmetry and WM network controllability. However, gender differences in controllability of hemispheric WM networks between males and females remain to be determined. Based on 1 principal atlas and 1 replication atlas, this work characterized the average controllability (AC) and modal controllability (MC) of hemispheric WM network based on 1 principal dataset and 2 replication datasets. All results showed that males had higher AC of left hemispheric networks than females. And significant hemispheric asymmetry was revealed in regional AC and MC. Furthermore, significant gender differences in the AC asymmetry were mainly found in regions lie in the frontoparietal network, and the MC asymmetry was found in regions involving auditory and emotion process. Finally, we found significant associations between regional controllability and cognitive features. Taken together, this work could provide a novel perspective for understanding gender differences in hemispheric WM asymmetry and cognitive function between males and females.
US Severe Acute Respiratory Syndrome Coronavirus 2 Epsilon Variant: Highly Transmissible but With an Adjusted Muted Host T-Cell Response
Authors: Plummer Jasmine T , Contreras Deisy , Zhang Wenjuan , Binek Aleksandra , Zhang Ruan , Dezem Felipe , Chen Stephanie S , Davis Brian D , Sincuir Martinez Jorge , Stotland Aleksandr , Kreimer Simion , Makhoul Elias , Heneidi Saleh , Eno Celeste , Shin Bongha , Berg Anders H , Cheng Susan ,   CORALE Study Group, Jordan Stanley C , Vail Eric , Van Eyk Jennifer E , Morgan Margie A 
Published: April 2022

Abstract

Background
The multiple mutations comprising the epsilon variant demonstrate the independent convergent evolution of severe acute respiratory syndrome coronavirus (SARS-CoV-2), with its spike protein mutation L452R present in the delta (L452R), kappa (L452R), and lambda (L452Q) variants.

Methods
Coronavirus disease 2019 (COVID-19) variants were detected in 1017 patients using whole-genome sequencing and were assessed for outcome and severity. The mechanistic effects of the epsilon versus non-epsilon variants were investigated using a multiomic approach including cellular response assays and paired cell and host transcriptomic and proteomic profiling.

Results
We found that patients carrying the epsilon variant had increased mortality risk but not increased hospitalizations (P &lt; .02). Cells infected with live epsilon compared with non-epsilon virus displayed increased sensitivity to neutralization antibodies in all patients but a slightly protective response in vaccinated individuals (P &lt; .001). That the epsilon SARS-CoV-2 variant is more infectious but less virulent is supported mechanistically in the down-regulation of viral processing pathways seen by multiomic analyses. Importantly, this paired transcriptomics and proteomic profiling of host cellular response to live virus revealed an altered leukocyte response and metabolic messenger RNA processing with the epsilon variant. To ascertain host response to SARS-CoV-2 infection, primary COVID-19–positive nasopharyngeal samples were transcriptomically profiled and revealed a differential innate immune response (P &lt; .001) and an adjusted T-cell response in patients carrying the epsilon variant (P &lt; .002). In fact, patients infected with SARS-CoV-2 and those vaccinated with the BNT162b2 vaccine have comparable CD4+/CD8+ T-cell immune responses to the epsilon variant (P &lt; .05).

Conclusions
While the epsilon variant is more infectious, by altering viral processing, we showed that patients with COVID-19 have adapted their innate immune response to this fitter variant. A protective T-cell response molecular signature is generated by this more transmissible variant in both vaccinated and unvaccinated patients.
Outpatient Versus Inpatient Intravenous Antimicrobial Therapy: A Population-Based Observational Cohort Study of Adverse Events and Costs
Authors: Staples John A , Ho Meghan , Ferris Dwight , Hayek Jan , Liu Guiping , Tran Karen C , Sutherland Jason M 
Published: April 2022

Abstract

Background
Bacterial infections such as osteomyelitis and endocarditis routinely require several weeks of treatment with intravenous (IV) antimicrobials. Outpatient parenteral antimicrobial therapy (OPAT) programs allow patients to receive IV antimicrobials in an outpatient clinic or at home. The outcomes and costs of such treatments remain uncertain.

Methods
We conducted a retrospective observational cohort study over a 5-year study interval (1 June 2012 to 31 March 2018) using population-based linked administrative data from British Columbia, Canada. Patients receiving OPAT following a hospitalization for bacterial infection were matched based on infection type and implied duration of IV antimicrobials to patients receiving inpatient parenteral antimicrobial therapy (IPAT). Cumulative adverse events and direct healthcare costs were estimated over a 90-day outcome interval.

Results
In a matched cohort of 1842 patients, adverse events occurred in 35.6% of OPAT patients and 39.0% of IPAT patients (adjusted odds ratio, 1.04 [95% confidence interval {CI}, .83–1.30; P = .61). Relative to IPAT patients, OPAT patients were significantly more likely to experience hospital readmission (30.5% vs 23.0%) but significantly less likely to experience Clostridioides difficile diarrhea (1.2% vs 3.1%) or death (2.0% vs 8.8%). Estimated mean direct healthcare costs were $30 166 for OPAT patients and $50 038 for IPAT patients (cost ratio, 0.60; average cost savings with OPAT, $17 579 [95% CI, $14 131–$21 027]; P &lt; .001).

Conclusions
Outpatient IV antimicrobial therapy is associated with a similar overall prevalence of adverse events and with substantial cost savings relative to patients remaining in hospital to complete IV antimicrobials. These findings should inform efforts to expand OPAT use.
Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients
Authors: Woldemeskel Bezawit A , Garliss Caroline C , Aytenfisu Tihitina Y , Johnston Trevor S , Cox Andrea L , Karaba Andrew H , Blankson Joel N 
Published: April 2022

Abstract
We compared antibody and T-cell responses against the severe acute respiratory syndrome coronavirus 2 vaccine strain spike protein to responses against the Omicron variant in 15 messenger RNA vaccine recipients. While these individuals had significantly lower levels of antibodies that inhibited Omicron spike protein binding to ACE2, there was no difference in T-cell responses.
Forging Partnerships and Fostering Wisdom: Dynamics of an Environmental Public Interest Litigation Network in Advocating Sustainable Municipal Solid Waste Management in China
Authors: Lin Yanmei , Wong Natalie W M 
Published: April 2022

Abstract
This article investigates the efforts of the Environmental Public Interest Litigation Network (EPIL Network) to understand how Chinese environmental civil society proactively created a network to mobilize resources, forge collaborative actions, and build capacities and foster wisdom to catalyze changes in the environmental rule of law and in the area of municipal solid waste management. Using civil society network analysis, this article aims to identify and account for interactions between the EPIL Network and other stakeholders, including the government. Finally, the study highlights the contributions of the EPIL Network, which provides an option for resolving political conflicts in China regarding municipal waste management.
Adam Smith’s Digression on Silver: the centrepiece of the Wealth of Nations
Authors: Paganelli Maria Pia 
Published: April 2022

Abstract
I suggest that Adam Smith’s ‘Digression on Silver’ should be read as his most powerful argument against mercantilism in the Wealth of Nations. For mercantilists money is wealth, according to Smith, and an increase in the quantity of silver, and the associated reduction in its value, implies higher prices in terms of silver. On the basis of this connection, mercantilists advocate trade protections to increase prices and therefore, in their view, wealth. Smith argues that this account obscures two processes occurring at the same time: a change in institutions that allows wealth to grow and leads to real prices decreasing, and a simultaneous increase in the quantity of silver leading to an increase in nominal prices. Overall, according to Smith, the nominal increase would be larger than the real decrease in prices. Mercantilists focused on nominal prices, attributing a causal relation between the decrease in the value of silver and an increase in wealth. Smith shows that correlation is not causation in this case, merely the coincidence of two simultaneous and independent processes. The Digression on Silver leaves mercantilists with nothing: what seems to be, is not what is. Money may seem to be wealth, but it is not: the ability to consume is.
Is the Italian government debt sustainable? Scenarios after the Covid-19 shock
Authors: Canelli Rosa , Fontana Giuseppe , Realfonzo Riccardo , Veronese Passarella Marco 
Published: April 2022

Abstract
The sustainability of the Italian government debt has been under close scrutiny since the launch of the Euro Area, and even more so after the Global Financial Crisis. The Covid-19 crisis in 2020 has depressed the Italian economy further and negatively affected the government budget. Despite the rebound in 2021, the state of the economy and government debt in Italy remain precarious. Building on Pasinetti’s work, this paper examines the sustainability of the Italian government debt through a medium-scale, stock-flow consistent, structural macroeconometric model. The model has been coded and calibrated using the R package Bimets developed by the Bank of Italy. Our findings show that the Italian government debt is unlikely to enter a sustainable trajectory in the next few years. While the Next Generation EU and the other fiscal and monetary measures are helping the Italian economy to recover, in the coming years, a greater effort on the part of the European authorities—including an intervention of the ECB in controlling the yield curve—seems necessary to stabilize the debt to GDP ratio in Italy.
Risk-based versus GFR threshold criteria for nephrology referral in chronic kidney disease
Authors: Oliva-Damaso Nestor , Delanaye Pierre , Oliva-Damaso Elena , Payan Juan , Glassock Richard J 
Published: April 2022

Abstract
Chronic kidney disease (CKD) and kidney failure are global health problems associated with morbidity, mortality and healthcare costs, with unequal access to kidney replacement therapy between countries. The diversity of guidelines concerning referral from primary care to a specialist nephrologist determines different outcomes around the world among patients with CKD where several guidelines recommend referral when the glomerular filtration rate (GFR) is &lt;30 mL/min/1.73 m2 regardless of age. Additionally, fixed non-age-adapted diagnostic criteria for CKD that do not distinguish correctly between normal kidney senescence and true kidney disease can lead to overdiagnosis of CKD in the elderly and underdiagnosis of CKD in young patients and contributes to the unfair referral of CKD patients to a kidney specialist. Non-age-adapted recommendations contribute to unnecessary referral in the very elderly with a mild disease where the risk of death consistently exceeds the risk of progression to kidney failure and ignore the possibility of effective interventions of a young patient with long life expectancy. The opportunity of mitigating CKD progression and cardiovascular complications in young patients with early stages of CKD is a task entrusted to primary care providers who are possibly unable to optimally accomplish guideline-directed medical therapy for this purpose. The shortage in the nephrology workforce has classically led to focused referral on advanced CKD stages preparing for kidney replacement, but the need for hasty referral to a nephrologist because of the urgent requirement for kidney replacement therapy in advanced CKD is still observed and changes are required to move toward reducing the kidney failure burden. The Kidney Failure Risk Equation (KFRE) is a novel tool that can guide wiser nephrology referrals and impact patients.
Yoga in Patients With Inflammatory Bowel Disease: A Narrative Review
Authors: Kaur Sandeep , D’Silva Adrijana , Shaheen Abdel-Aziz , Raman Maitreyi 
Published: April 2022

Abstract
Despite advancements in the treatment of inflammatory bowel disease (IBD), the global prevalence of IBD is increasing. Patients with IBD often experience a high psychosocial burden, worsening their IBD symptoms and increasing relapse, hospitalization rates, and healthcare costs, which impairs their quality of life (QoL). Evidence suggests that mind–body intervention in many chronic illnesses is effective in improving symptoms and QoL. Yoga is the most frequently used mind–body practice globally. Meta-analyses of randomized clinical trials and prospective studies have highlighted that yoga improves symptoms and QoL of patients with IBD; however, recommendations about indications for yoga as well as dose and frequency of yoga are lacking. The present narrative review aims to describe the available evidence regarding the effects of yoga on common patient-reported outcome measures in IBD, including depression, anxiety, stress, and QoL. Physicians can hence promote yoga interventions in their discussions with patients to help control these IBD-related outcome measures.
Chromosome-level genome assembly and characterization of Sophora Japonica
Authors: Lei Weixiao , Wang Zefu , Cao Man , Zhu Hui , Wang Min , Zou Yi , Han Yunchun , Wang Dandan , Zheng Zeyu , Li Ying , Liu Bingbing , Ru Dafu 
Published: April 2022

Abstract
Sophora japonica is a medium-size deciduous tree belonging to Leguminosae family and famous for its high ecological, economic and medicinal value. Here, we reveal a draft genome of S. japonica, which was ∼511.49 Mb long (contig N50 size of 17.34 Mb) based on Illumina, Nanopore and Hi-C data. We reliably assembled 110 contigs into 14 chromosomes, representing 91.62% of the total genome, with an improved N50 size of 31.32 Mb based on Hi-C data. Further investigation identified 271.76 Mb (53.13%) of repetitive sequences and 31,000 protein-coding genes, of which 30,721 (99.1%) were functionally annotated. Phylogenetic analysis indicates that S. japonica separated from Arabidopsis thaliana and Glycine max ∼107.53 and 61.24 million years ago, respectively. We detected evidence of species-specific and common-legume whole-genome duplication events in S. japonica. We further found that multiple TF families (e.g. BBX and PAL) have expanded in S. japonica, which might have led to its enhanced tolerance to abiotic stress. In addition, S. japonica harbours more genes involved in the lignin and cellulose biosynthesis pathways than the other two species. Finally, population genomic analyses revealed no obvious differentiation among geographical groups and the effective population size continuously declined since 2 Ma. Our genomic data provide a powerful comparative framework to study the adaptation, evolution and active ingredients biosynthesis in S. japonica. More importantly, our high-quality S. japonica genome is important for elucidating the biosynthesis of its main bioactive components, and improving its production and/or processing.