bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Perceived Social Presence on the Willingness to Communicate in Mobile Medical Consultations: Experimental Study
Authors: Chen Lijuan , Zhang Danyang , Hou Mutian 
Published: May 2022

Background
With the rise of online health care service, there is growing discussion on the relationship between physicians and patients online, yet few researchers have paid attention to patients’ perception of social presence, especially its influence on their willingness to communicate (WTC).

Objective
The goal of the research is to investigate the influence of perceived social presence (PSP) on WTC in mobile medical consultations.

Methods
Participants living in Yunnan province during the period of middle to high risk of COVID-19 infection were recruited via the internet. They were assigned randomly into 2 groups interacting with a virtual physician presenting high and low levels of social presence and then asked to complete a questionnaire. Based on the theoretical framework, the study puts forward a model evaluating the relationships among participants’ PSP, communication apprehension (CA), self-perceived communication competence (SPCC), and willingness to communicate about health (WTCH) in the computer-mediated communication between virtual physicians and patients.

Results
In total 206 (106 in group 1 and 100 in group 2) valid samples were gathered (from 276 log-ins) and 88.8% (183/206) of them were aged 18 to 44 years, which approximately resembles the age distribution of the main population engaging in online medical consultation in China. Independent t test shows that there is significant difference between the PSP of the 2 groups (P=.04), indicating a successful manipulation of social presence. The total effect of PSP on WTCH is 0.56 (P<.001), among which 74.4% is direct effect (P<.001). Among the indirect effects between PSP and WTCH, the mediating effect of SPCC accounts for 68.8% (P<.001) and the sequential mediating effect of CA→SPCC accounts for 19.2% (P<.001), while the mediating effect of CA alone is not significant (P=.08).

Conclusions
This study provides a comprehensible model, demonstrating that PSP is an important antecedent of WTCH, and the sequential mediating effect of CA and SPCC found in this study also proves that in the environment of online mobile medical services, CA cannot affect communication directly. The findings will provide some practical inspiration for the popularization of online medical service, especially for the promotion of online physician-patient communication.
Research on Digital Technology Use in Cardiology: Bibliometric Analysis
Authors: Yeung Andy Wai Kan , Kulnik Stefan Tino , Parvanov Emil D , Fassl Anna , Eibensteiner Fabian , Völkl-Kernstock Sabine , Kletecka-Pulker Maria , Crutzen Rik , Gutenberg Johanna , Höppchen Isabel , Niebauer Josef , Smeddinck Jan David , Willschke Harald , Atanasov Atanas G 
Published: May 2022

Background
Digital technology uses in cardiology have become a popular research focus in recent years. However, there has been no published bibliometric report that analyzed the corresponding academic literature in order to derive key publishing trends and characteristics of this scientific area.

Objective
We used a bibliometric approach to identify and analyze the academic literature on digital technology uses in cardiology, and to unveil popular research topics, key authors, institutions, countries, and journals. We further captured the cardiovascular conditions and diagnostic tools most commonly investigated within this field.

Methods
The Web of Science electronic database was queried to identify relevant papers on digital technology uses in cardiology. Publication and citation data were acquired directly from the database. Complete bibliographic data were exported to VOSviewer, a dedicated bibliometric software package, and related to the semantic content of titles, abstracts, and keywords. A term map was constructed for findings visualization.

Results
The analysis was based on data from 12,529 papers. Of the top 5 most productive institutions, 4 were based in the United States. The United States was the most productive country (4224/12,529, 33.7%), followed by United Kingdom (1136/12,529, 9.1%), Germany (1067/12,529, 8.5%), China (682/12,529, 5.4%), and Italy (622/12,529, 5.0%). Cardiovascular diseases that had been frequently investigated included hypertension (152/12,529, 1.2%), atrial fibrillation (122/12,529, 1.0%), atherosclerosis (116/12,529, 0.9%), heart failure (106/12,529, 0.8%), and arterial stiffness (80/12,529, 0.6%). Recurring modalities were electrocardiography (170/12,529, 1.4%), angiography (127/12,529, 1.0%), echocardiography (127/12,529, 1.0%), digital subtraction angiography (111/12,529, 0.9%), and photoplethysmography (80/12,529, 0.6%). For a literature subset on smartphone apps and wearable devices, the Journal of Medical Internet Research (20/632, 3.2%) and other JMIR portfolio journals (51/632, 8.0%) were the major publishing venues.

Conclusions
Digital technology uses in cardiology target physicians, patients, and the general public. Their functions range from assisting diagnosis, recording cardiovascular parameters, and patient education, to teaching laypersons about cardiopulmonary resuscitation. This field already has had a great impact in health care, and we anticipate continued growth.
VALIDATED SPECTROPHOTOMETRIC METHODS BASED ON CHARGE TRANSFER COMPLEXATION REACTION FOR THE DETERMINATION OF VALACYCLOVIR HYDROCHLORIDE AS ANTIVIRAL DRUG IN PHARMACEUTICAL FORMULATIONS
Authors: AMIN ALI H. , EL SHEIKH RAGAA , YOUSSEF AHMED O. , ABDEL FATTAH GHADA M. , GOUDA AYMAN A. 
Published: May 2022

Objective: The present study aims to develop and validate two simple, sensitive, accurate, precise and economical spectrophotometric methods for the determination of valacyclovir HCl (VAL) in pure form and pharmaceutical formulations.
Methods: The developed methods are based on the formation of charge-transfer complex between VAL as n-electron donor and quinalizarin (Quinz) or alizarin red S (ARS) as π-acceptor in methanol to form highly colored chromogens, which showed an absorption maximum at 565 and 540 nm using Quinz and ARS, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated.
Results: Under the optimum conditions, Beer’s law is obeyed in the concentration ranges 0.5–16 and 1.0–20 μg/ml using Quinz and ARS, respectively, with good correlation coefficient (r2 ≥ 0.9994) and with a relative standard deviation (RSD% ≤ 0.70). The limits of detection and quantification were found to be 0.15 and 0.30 µg/ml for Quinz and 0.50 and 1.0 µg/ml for ARS.
Conclusion: The methods were successfully applied to the determination of VAL in its pharmaceutical formulations and the validity assesses by applying the standard addition technique. Results obtained by the proposed methods for the pure VAL and commercial tablets agreed well with those obtained by the reported method.
The Realization of Directive Illocutionary Act of Male and Female English Teachers in Junior High School
Authors: Amalia Euis . , Husein Rahmad . , Pulungan Anni Holila 
Published: May 2022

This study deals with Directive Illocutionary Act of male and female English Teacher in SMP Ad-Durrah Medan. The objectives of this study is to describe the realization of directive illocutionary act of male and female English teachers at SMP Ad-Durrah Medan. This study applied qualitative descriptive method. The techniques for collecting data are through applying observation by taking eight meetings for male and female English teachers to get realization of directive illocutionary act by male and female English. The results of this study found that realization of directive illocutionary act realized from the collaborative, competitive, conflictive , and convivial, where one of the realization was showed that the teacher makes a group discussion for doing the task and the teachers help the students by making a discussion for each student, making a collaboration for their task related to the content of their lesson and presenting the discussion in the class.
TRANSITIVITY SYSTEM IN CNN ONLINE NEWS
Authors: Qomariah Nurul . , Saragih Amrin . , Murni Sri Minda 
Published: May 2022

This study was concerned with the types of transitivity system elements in CNN Online News. The objectives of this descriptive qualitative study were to discover: (1) the types of transitivity system, (2) the realization of transitivity system, and (3) the reasons for transitivity system realized in CNN Online News. The data of this study were clauses that consist of a transitivity system in 10 Covid-19 Online News taken from CNN Online News. The results of the study showed that: 1) CNN Online News realized all the types of process: Material, Mental, Relational, Behavioral, Verbal, and Existential process. The dominant process was Material Process. It was realized 214 (50,47%). CNN Online News realized participants: Actor, Goal, Sayer, Carrier, Attribute, Verbiage, Senser, Phenomenon, Target, Existing, Existence, Behaver, Token, Value, Receiver, Behavior, and Range. Actor and Goal were dominantly realized in the clauses of CNN Online News, there were 167 (26,38%) of Actor and 141 (22,27%) of Goal. The most dominant was Actor, and CNN Online News realized circumstances: Location, Cause, Manner, Accompaniment, Extent, Matter, Angle, and Role. It was realized 193 (60, 50%). The dominant was Location; 2) There were congruent realization and incongruent realization of transitivity system. The most dominant realization was congruent realization; 3) The reason why the types of transitivity system realized in CNN Online News is based on the context of the situation related to the field. Field stand for three entries, namely arena/social activity [+institutionalized/-institutionalized], participant’s characteristics [person/social] and semantic domain [+specialized/-specialized]. The most dominant was arena/social activity, especially [-institutionalized]. Keywords: Metafunction, Transitivity System, Online News, CNN
The Nobel Prize in Physiology or Medicine 2018 was awarded to Cancer Therapy by Inhibition of Negative Immune Regulation
Authors: Furukawa Fukumi 
Published: May 2022

On October 1, The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to Dr. James P. Allison and Dr. Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation.The Nobel Assembly at Karolinska Institute released the comments that Dr. Allison and Dr. Honjo showed how different strategies for inhibiting the brakes on the immune system could be used in the treatment of cancer [1-5]. The seminal discoveries by the two laureates constitute a landmark in our fight against cancer. https://www.nobelprize.org/prizes/medicine/2018/prize-announcement/I sincerely wish to congratulate two recipients, co-workers and many patients cooperated in clinical trials. In this journal, we have published several reviews and papers on immunity checkpoints so far. The reason is that the mission of this journal is in scientific awareness and dissemination of new immunotherapy.I herein introduce briefly my previous report with some modification [6]. Immune checkpoints inhibitors (ICIs) have opened promising avenues in the treatment of cancer. Various blocking antibodies targeting programmed cell death -1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are approved for human use. They significantly improved disease outcome in a number of cancer patients by boosting anti-tumor immune responses. As Seidel, Otsuka and Kabashima described in their review article [7], mortality among advanced stage patients and the frequency of treatment-related adverse events remain high with current treatment. And, it is also noteworthy that unexpected immune related adverse effects (irAEs) appear, even when it becomes better to be administered to many cancer patients [8]. Unfortunately, the mechanisms of endocrine irAEs by ICIs, remain unclear, and optimal prevention, prediction, and treatment of the irAEs are still uncertain. However, appropriate uses and index setting related to prognosis are being studied in many fields such as dermatology [9] and other organs [6,7].While solving such problems, we have to understand that the mechanisms of immunogenic cell death are now moving from concepts to the clinic. We will explain the mechanism behind ICD and how it will perhaps breathe a new life into chemotherapy use in cancer, not front and center but as a helpful hand to immunotherapy [10].For a long time many scientists or doctors attempted to engage the immune system in the fight against cancer. Many clinicians stared at cancer patients who were to be dying by their side, mourning their inability. However, cancer therapy by inhibition of negative immune regulation checkpoint therapy has fundamentally changed the way we view how cancer can be managed and many patients will receive much better care and cure.
Point-of-care ketone meters may be used to estimate serum β-hydroxybutyrate concentrations in healthy African penguins (Spheniscus demersus)
Authors: Meade Sharonda M. , Di Girolamo Nicola , Cray Carolyn , Aquilino Nicolette , DiGeronimo Peter M. , Brandão João 
Published: May 2022

Abstract

OBJECTIVE
To evaluate the agreement between 3 point-of-care (POC) devices and a reference laboratory for measuring β-hydroxybutyrate (β-HB) concentration in African penguin (Spheniscus demersus) whole blood (WB) and plasma samples and the precision of each POC device for measuring β-HB concentration in plasma samples.

ANIMALS
48 healthy African penguins.

PROCEDURES
Blood was obtained from the right jugular vein of each penguin, and β-HB concentration was measured on each POC device using fresh WB and heparinized plasma and at the reference laboratory using plasma. β-HB concentration was measured in plasma on each POC device.

RESULTS
All devices overestimated serum β-HB concentrations on average by 0.46 mM relative to the reference laboratory. WB samples had less error than plasma for meters A and C. Meter A had the lowest total error observed (26.4%) and the lowest mean difference (0.19 mmol/L) relative to the reference laboratory. Controlling for other factors, the magnitude of disagreement was not affected by sex, age, packed cell volume, or serum total solids concentration.

CLINICAL RELEVANCE
WB, not plasma, should be used for measurement of β-HB concentration on the POC meters tested. Meter A showed good correlation with the reference laboratory for WB. The use of POC devices for the measurement of β-HB concentration may be acceptable when laboratory analyzers are not available. Further research is needed for clinical application and the diagnostic value of POC meters compared with reference laboratories.
When radiography and ultrasonography are not enough: the use of computed tomography and magnetic resonance imaging for equine lameness cases
Authors: Garrett Katherine S. 
Published: May 2022

Abstract
MRI and CT have enhanced our diagnostic abilities for equine lameness beyond what is available using radiography and ultrasonography. This has allowed veterinarians to better prognosticate and treat lameness conditions, improving patient outcomes. This article discusses the basic principles behind MRI and CT, their advantages and disadvantages, the different types of equipment available for clinical use in horses, the typical diagnostic workup prior to pursuing advanced imaging, and common regions where MRI and CT are used clinically. The companion Currents in One Health by Spriet, AJVR, July 2022, discusses even more advanced equine imaging in the form of positron emission tomography. Combined, these future directions of MRI, CT, and positron emission tomography may include improved ability to image standing horses or screen for injury prevention.
Pharmacist-led Smoking-Cessation Services in the United States – A Multijurisdictional Legal Analysis
Authors: Bordner Landon S. , Lavino Joseph 
Published: May 2022

A challenge presents itself when pharmacy students and pharmacists have the knowledge, skills, and abilities to provide optimal patient care, which can prevent the healthcare industry from incurring expenditures reaching billions of dollars annually from chronic and acute disease state management, yet due to the lack of statutory or regulatory authority to independently prescribe and dispense smoking cessation products they are unable to tap into this potential.
Prescriptive authority of pharmacists is not a novel concept; however, State Legislatures and Boards of Pharmacy have been slow to expand upon the pharmacist’s scope of practice to include this authority. As a consequence, this inaction hinders the opportunity of almost 21.5 million patients, who attempt to quit smoking annually, the ability to access a U.S. Food and Drug Administration approved, evidence-based medication-assisted or nicotine replacement therapy prescribed by a pharmacist.2 Current legislative efforts, laws, and regulations regarding a pharmacist’s prescriptive authority for tobacco cessation therapy vary greatly amongst the states and do not include reference to e-cigarettes or electronic nicotine delivery systems (e.g., e-cigs, vape pens, vapes, mods, etc.). Additionally, pharmacists are often required to practice under a statewide protocol or enter into a collaborative practice agreement (“CPA”) with a designated physician, which are often complex and create significant barriers for the pharmacist to practice at the top of their license and for the benefit of the patient. This legal and regulatory study reveals the following: 1) Those States that have addressed or attempted to address the pharmacist’s prescriptive authority for tobacco cessation therapy, 2) the authority to independently prescribe vs. practice under a statewide protocol, 3) the products able to be prescriber or dispensed under the pharmacist’s prescriptive authority or statewide protocol, and 4) the guidelines and/or protocols referenced within their respective State laws and regulations. States and their residents would benefit greatly from amending their laws and regulations to expand upon the pharmacist’s prescriptive authority, granting them the ability to help their communities by performing services they are highly trained to perform.
A concentração de IL-6 em pacientes com artrite reumatoide tratados com tocilizumabe: revisão integrativa
Authors: Sampaio Leidiana Sousa , Silva Amanda Miranda da , Aguiar Lizia Carreiro Tomaz , Chaves Soane Kaline Morais , Nunes Adriana Maria Viana , Braz Débora Cavalcante 
Published: May 2022

Objetivo: Avaliar se a concentração de Interleucina-6 (IL-6) pode ser utilizada para o monitoramento da resposta ao tratamento com Tocilizumabe (TCZ) em pacientes com artrite reumatoide. Métodos: Trata-se de uma revisão integrativa sustentada em uma pergunta norteadora. Apenas estudos em humanos tratados com TCZ e que apresentavam a concentração de IL-6 foram incluídos. As bases de dados utilizadas foram PubMed, Scientific Electronic Library Online (SciELO) e Biblioteca virtual em saúde (BVS). Resultados: Foram encontrados 257 artigos, no entanto após aplicação dos critérios de inclusão e exclusão apenas 7 artigos foram considerados resultado da pesquisa. A análise dos artigos indica que há uma elevação da concentração de IL-6 após o início da terapia, seguida de um platô e, posteriomente, diminuição com o tempo de tratamento, que foi acompanhada de melhora clínica. Considerações finais: Esse fato sugere a mensuração de IL-6 como um parâmetro importante para monitorar a resposta terapêutica. Para isso, o ideal seria realizar a dosagem de IL-6 antes, durante e após a suspensão do tratamento nos pacientes com remissão da doença. Apenas através de pesquisas será possível padronizar a utilização da IL-6 nesses pacientes.
Papanicolaou society of cytopathology system for reporting pancreaticobiliary cytology: Risk stratification and cytology scope - 2.5-year study
Authors: Ilyas Abeer M , Bohra Mamta , More Nilam M. , Naik Leena P. 
Published: May 2022

Objectives:
Diagnosis of pancreatic lesions remains a clinical challenge. Early and accurate diagnosis is extremely important for improving the therapeutic usefulness of pancreatic cancers and Endoscopic ultrasonography - fine needle aspiration (EUS-FNA) cytology has come up with this advantage. For current study the authors evaluated the diagnostic accuracy of EUS-FNAC by applying PSC system for reporting pancreaticobiliary cytology and Calculated the malignancy risk associated with the diagnostic categories.

Material and Methods:
A retrospective study over the period of 2.5 years (April 2017 to Oct 2019) 60 patients in our cohort EUS-FNAC guided unstained fixed and unfixed slides received of pancreatic lesion and were stained with Papanicolau and Giemsa using standard technique and immunocytochemistry, where required Application of Papanicolaou Society of Cytopathology system for reporting pancreaticobiliary cytology Histopathological and clinical follow-up were retrieved.

Results:
Our study has comparable results with sensitivity, specificity, PPV, and NPV of 92.8%, 100%, 100%, and 92.59%, respectively. Fuurthermore, a diagnostic accuracy of 96.2%. Risk of malignancy is lower for benign and indeterminate category whereas it is higher for suspicious and malignant categories.

Conclusion:
The application of the new proposed terminology for pancreaticobiliary cytology brings standardization. Final diagnosis can be reached by the multidisciplinary approach of EUS-FNA cytology, cell block preparation, immunocytochemistry, and immunohistochemistry; if required, can be adopted as an alternative approach to biopsy. The present study showed high sensitivity and specificity for EUS-FNA in the diagnosis of pancreatic carcinoma, which may influence the treatment plans of both surgeons and oncologists.
Ecological culture as a vector of updating the main educational programs
Authors: Дзятковская Е. Н. 
Published: May 2022

Рассмотрена роль экологической культуры как фактора устойчивого развития страны. Обосновывается, что экологическая культура в современном обществе становится средством обеспечения всех направлений национальной безопасности страны, ее культурного суверенитета, решения экологических, социальных и экономических проблем. Поставлена проблема отражения статуса экологической культуры в современном обществе при разработке основных образовательных программ общеобразовательных организаций. Делается заключение о необходимости обновления целей и ценностных оснований проектирования основных образовательных программы на основе культурологической парадигмы образования и задачи формирования экологической культуры обучающихся.
The role of ecological culture as a factor of sustainable development of the country is considered. It is substantiated that ecological culture in modern society becomes a means of ensuring all directions of national security of the country, its cultural sovereignty, solving ecological, social and economic problems. The problem of reflection of ecological culture status in modern society during development of basic educational programs of general educational organizations is put. The conclusion about necessity of updating of purposes and value bases of design of the basic educational programs on the basis of cultural paradigm of education and the task of formation of ecological culture of students is made.