bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercising with Parkinson's: The good, the bad and the need for support to keep exercising. A qualitative study
Authors: Flynn Allyson , Dennis Sarah , Preston Elisabeth , Canning Colleen G , Allen Natalie E 
Published: May 2022

Objectives To explore the experiences of people with Parkinson's disease exercising and to determine if the location (home versus centre) or exercising in a group impacted on their experience. Design A qualitative study. Participants Community-dwelling people with mild to moderate Parkinson's disease who had undertaken a 10-week exercise intervention. Method Semi-structured interviews were conducted with 17 participants; nine participants had completed 10-weeks of predominately home-based exercise and eight participants had predominately centre-based excercise. Interviews were recorded, transcribed verbatim and analysed using inductive thematic analysis. Results Four key themes emerged. Two themes: ‘targeted exercise is important when you have Parkinson's disease’ and ‘support helps me to gain the most from the exercise’, were related to exercising with Parkinson's disease and were not specific to location. Two themes encompassed the perceptions when exercising at a centre in a group compared to exercising at home: ‘the good and the bad of exercising in a group’ and ‘exercising at home, can I do it?’ Conclusion Experiences of people with Parkinson's disease when exercising were primarily influenced by the prescription of specific exercise and the support provided. There was no clear preference for the location of exercise but maintaining the motivation to exercise at home was challenging.
Efficacy and safety of supraphysiologic doses of levothyroxine for patients with bipolar depression in adults: A systematic review
Authors: George Seena , Maiti Rituparna , Mishra Archana , Ranjan Mishra Biswa , Jena Monalisa 
Published: May 2022

Background: In bipolar disorder (BD), depression is the most difficult-to-treat dimension and available evidence suggests that add-on supraphysiological doses of levothyroxine may be an effective augmenting agent. Aim: This systematic review has been conducted to evaluate the efficacy and safety of supraphysiologic doses of levothyroxine in bipolar depression in adults. Methods: After a comprehensive literature search on MEDLINE/PubMed, Scopus, Cochrane databases and International Clinical Trial Registry Platform (ICTRP), reviewers extracted data from eight relevant articles. PRISMA guidelines were followed in the selection, analysis and reporting of findings. Quality assessment was done using the risk of bias assessment and a random effects model was used to estimate effect size. Meta-analysis could not be done due to the lack of randomized, placebo-controlled trials and adequate data. A systematic review was done on eight studies and analysis on the pre–post change in Hamilton depression rating scale score (HDRS) was done for six studies. Results: The random model analysis of pooled effects showed a standardized mean difference of HDRS score by 2.62 (95% CI: 2.21–3.04; p < 0.0001). The responder and remission rates were not significant as reported in one study. Markov chain analysis performed in one study revealed that patients in the levothyroxine group had a significantly greater increase in time in the euthymic state and a decrease in the mixed state. In most of the studies, levothyroxine therapy was well tolerated, with no serious adverse events. Conclusion: Add-on supraphysiological dose of levothyroxine has a potential role in attenuating depressive symptoms in bipolar depression, especially in therapy-resistant BD. PROSPERO Registration Number: CRD42020218456.
Males and females differ in reported sexual functioning with escitalopram treatment for major depressive disorder: A CAN-BIND-1 study report
Authors: Espinola Caroline W , Khoo Yuelee , Parmar Roohie , Demchenko Ilya , Frey Benicio N , Milev Roumen V , Ravindran Arun V , Parikh Sagar V , Ho Keith , Rotzinger Susan , Lou Wendy , Lam Raymond W , Kennedy Sidney H , Bhat Venkat 
Published: May 2022

Background: Antidepressant use for major depressive disorder (MDD) is frequently associated with sexual dysfunction. Aims: Cross-sectional and longitudinal relationships between antidepressant treatment outcomes and sexual functioning (SF) were evaluated separately for males and females receiving escitalopram. We further assessed the association between pre- and posttreatment SF. Methods: In all, 208 of the 211 CAN-BIND-1 trial participants (77 males and 131 females) with MDD and detectable drug blood levels were eligible for the analyses. All received escitalopram (10–20 mg) for 8 weeks. At baseline and Week 8, participants completed the Montgomery–Åsberg Depression Rating Scale (MADRS) and the SexFx scale, which measures sexual satisfaction and SF frequency. Mixed-model repeated measures assessed baseline to Week 8 SF changes among participants with different response/remission statuses. Multiple linear regression analyses examined SF differences between treatment outcomes at Week 8 as well as associations between pretreatment and eventual SF. Results: For both sexes, overall sexual satisfaction improved among responders but not among nonresponders ( p < 0.05). For females, overall SF frequency did not change significantly over time regardless of response status. For males, overall SF decreased significantly among nonresponders; orgasm decreased significantly among nonresponders and, to a lesser extent, among responders ( p < 0.05). For both sexes, pretreatment SF was significantly associated with SF at Week 8 across all domains ( p < 0.05). Conclusion: For both sexes, sexual satisfaction improves with response to escitalopram. For females, the response does not correspond to improvements in SF frequency. For males, SF frequency, particularly that of orgasm, declines regardless of response/nonresponse. ClinicalTrials.gov identifier: NCT01655706
Determinants of Low-Income Women’s Participation in Self-Collected Samples for Cervical Cancer Detection: Application of the Theory of Planned Behavior
Authors: Asare Matthew , Lanning Beth A. , Montealegre Jane R. , Akowuah Emmanuel , Adunlin Georges , Rose Tiffany 
Published: May 2022

Background Low-income women (LIW) are underrepresented in physician-provided cervical cancer screening. Providing women with an option for Human Papillomavirus (HPV) self-sampling would increase cervical cancer screening. However, little is known about LIW’s attitude towards self-sampling for cervical cancer. We determined the associations between the Theory of Planned Behavior (TPB) constructs and LIW intention for participation in the HPV self-sampling. Methods A 44-item survey was administered among women receiving food from a food pantry in central Texas. Independent variables included TPB constructs (i.e., attitudes, subjective norms, and perceived control). The outcome variables were intentions and preference for self-sampling. Both variables were measured on a 5-point scale. Hierarchical linear regression models were used to analyze the data. Results A sample of 241 participants (age 50.13 ± 9.60 years) comprising non-Hispanic White (40%), Black/African American (27%), and Hispanic (30%) participated in the study. The participants were current with a pap test (54.8%) and preferred self-sampling (42%). The participant’s attitudes and subjective norms were significantly associated with their intention for self-sampling, accounting for 38.7% of the variance ( p < .001). Women who were overdue for pap testing versus current with pap testing had increased odds of preferring self-sampling (OR = 1.72, 95% CI: 1.27, 6.04). Conclusions The key predictors for LIW’s intention for self-sampling included attitudes and subjective norms. Future research should use the TPB as a framework to examine whether intention predicts self-sampling behavior among LIW.
Delayed visit and treatment of lung cancer during the coronavirus disease 2019 pandemic in Japan: a retrospective study
Authors: Terashima Takeshi , Tsutsumi Akihiro , Iwami Eri , Kuroda Aoi , Nakajima Takahiro , Eguchi Keisuke 
Published: May 2022

Objective The impact of the coronavirus disease 2019 (COVID-19) pandemic on cancer care remains a concern. We aimed to evaluate access to diagnosis and treatment for lung cancer during the pandemic. Methods Times (days) from lung cancer symptom onset or referral to visit (pre-visit time), from visit to diagnosis (pre-diagnosis time), and from diagnosis to treatment (pre-treatment time) during the pandemic were compared with the times during the pre-pandemic period. Results The number of patients diagnosed with lung cancer was 82 and 75 during the pandemic and pre-pandemic periods, respectively. The percentage of patients with advanced-stage cancer was higher (65.9% vs. 46.7%), the percentage of patients treated with surgery was lower and the percentage treated with medication was higher (24.4% vs. 41.3% and 57.3% vs. 40.0%, respectively), the pre-visit time was longer (28.2 vs. 11.4 days), and the pre-treatment time for surgery was longer (67.3 vs. 45.6 days) during the pandemic compared with the times during the pre-pandemic period, respectively. Conclusions The COVID-19 pandemic resulted in delayed diagnoses, which could have led to patients being diagnosed with advanced disease. The pandemic also resulted in delayed therapy owing to the requirement for available intensive care unit beds for emergencies, including surgery.
Role of cervical cancer screening during prenatal checkups for infectious diseases: A retrospective, descriptive study
Authors: Maruyama Yasuyo , Sukegawa Akiko , Yoshida Hiromi , Iwaizumi Yukiha , Nakagawa Sayako , Kino Tamina , Suzuki Yukio , Kubota Kazumi , Hirabuki Tomoo , Mizushima Taichi , Miyagi Etsuko 
Published: May 2022

Objective This study was conducted to evaluate the status and role of cervical cytology affected by human papillomavirus infection and other infectious diseases screened during routine prenatal checkups. Methods We retrospectively examined medical records containing the screening results for infectious diseases and cervical cancer in women who delivered neonates in our hospital from 2014 to 2017. Results Among 3393 deliveries, 18.8% of women underwent a regular cervical cancer screening within 1 year of becoming pregnant, and 2641 women underwent a cervical cytology screening during this pregnancy. The cytological diagnostic results showed that 2562 women (97.0%) were negative for intraepithelial lesions or malignancy, whereas 79 (3.0%) had abnormal results. Of those with abnormal cytology results, 70 had abnormal cytology that was newly detected in this pregnancy, and 42 had grade ≥1 cervical intraepithelial neoplasia lesions. Spatulas were the most frequently used cytological sampling instruments, followed by cotton swabs. Cervical cytology revealed no major adverse reactions during these pregnancies. Conclusions Our results confirm the importance of screening for infectious diseases during pregnancy. Only 20% of the women underwent a regular pre-pregnancy cervical cytology screening. Cervical cytology screening during pregnancy may currently be playing a crucial role in preventing cervical cancer in Japan.
Evaluation of health-related quality of life and influencing factors in patients with Crohn disease
Authors: Gao Nan , Qiao Zhenguo , Yan Su , Zhu Lanxiang 
Published: May 2022

Objective We assessed levels of anxiety and depression in patients with Crohn disease (CD) to identify predictors of health-related quality of life (HRQOL). Methods In this case-control study, we enrolled 50 adult patients with CD and 50 matched, healthy controls. All participants completed self-administered questionnaires including the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Short Form-36 Health Survey (SF-36), and Short Inflammatory Bowel Disease Questionnaire (IBDQ, patients only). We analyzed the relationship between HRQOL and influencing factors. Results Mean total scores on the SAS, SDS, and SF-36 were significantly different between patients and controls. IBDQ scores among patients in the active phase of CD were significantly lower than those in remission phase. SF-36 scores were significantly lower in patients with CD compared with healthy controls. SF-36 scores among patients with active CD were significantly lower than scores among those in remission, and SF-36 scores in patients without complications were significantly higher than in those with complications. SF-36 scores in patients with good nutritional status were also significantly higher than scores in malnourished patients with CD. Conclusions Depression, anxiety, disease activity, complications, and nutritional status were predictive factors of decreased HRQOL in patients with CD.
Classification of Flexible Pavements Based on Texture Data
Authors: Sabillon Christian A. , Hernandez Joaquin , Bassil Maria , Prozzi Jorge 
Published: May 2022

The strong correlations between pavement texture and other surface characteristics—such as friction, drainage, and noise—are widely known. However, those relationships are not straightforward and have a strong dependency on the type and properties of the pavement surface. Incorporating surface information into a prediction model for skid resistance has the potential to drastically increase its predictive power. Nonetheless, in practice, pavement surface information is often unknown at the network level and must be inferred based on local expertise. The objective of this study was to address this issue by developing an objective classification model capable of identifying different asphalt pavement surfaces with a high degree of accuracy using only field texture data. High-resolution texture data were collected on 21 highway sections with varying surface types within 60 mi of the city of Austin, Texas using a prototype developed in house. Sophisticated data-processing algorithms were created to ensure the data used in developing the classification model were of the highest possible quality. Based on the most recent literature on the topic, more than 20 texture summary statistics were assessed during this study to find the best combination to predict surface characteristics of asphalt pavements. The results are robust and indicate that texture summary statistics alone, when used in the right combination, have enough information to develop a pavement surface classification model with a predictive power as high as 89% based on the F1 score.
Cardiac power output index to define hemodynamic response to Impella support in cardiogenic shock
Authors: Sern Lim Hoong 
Published: May 2022

Background: Early assessment of response to Impella in cardiogenic shock may guide escalation of mechanical circulatory support. Therapeutic goal and response to Impella have not previously been defined. This study tested the hypothesis that targeting 3-h post- Impella cardiac power output index (CPOi)—“hemodynamic response”—in cardiogenic shock is associated with 12-h lactate clearance. Methods: Single-center study of 37 consecutive patients who underwent left-sided Impella support for cardiogenic shock due to either acute myocardial infarction or decompensated heart failure. Patients who achieved 3-h post-Impella CPOi ⩾ 0.30 W/m2 were defined as Impella “hemodynamic responder.” Results: Twelve of the thirty-seven patients achieved 3-h post-impella CPOi  ⩾ 0.30 W/m2 (“hemodynamic responders”). Post-Impella CPOi correlated with 12-h lactate ( r = −0.779, p < 0.001) and lactate clearance ( r = 0.747, p < 0.001). “Hemodynamic responders” had lower 12-h lactate level and greater 12-h lactate clearance (52 (44–58) vs 17 (14–26)%, p < 0.001). Higher pre-Impella norepinephrine dose (−0.341, p = 0.003) and baseline lactate (−0.009, p = 0.003) were independently associated with lower 3-h post-Impella CPOi. Eighteen patients died within 30 days (2/12 “hemodynamic responders” compared to 16/25 “non-responders,” p < 0.001). Conclusion: Patients who achieved early 3-h post-Impella CPOi of ⩾0.30 W/m2 have greater lactate clearance and better short-term survival. Early post-Impella CPOi of 0.30 W/m2 may be used as a therapeutic goal and define favorable response to Impella in cardiogenic shock.
Impact of the COVID-19 Pandemic on Older Adult Driving in the United States
Authors: Betz Marian E. , Fowler Nicole R. , Han S. Duke , Hill Linda L. , Johnson Rachel L. , Meador Lauren , Omeragic Faris , Peterson Ryan A. , DiGuiseppi Carolyn 
Published: May 2022

Objectives: To examine how the COVID-19 pandemic affected driving and health outcomes in older adults. Methods: We compared Advancing Understanding of Transportation Options (AUTO) study participants enrolled before (December 2019 to March 2020) versus during the pandemic (May 2020 to June 2021). Participants were English-speaking, licensed drivers (≥70 years) who drove weekly and had a primary care provider at a study site and ≥1 medical condition potentially associated with driving cessation. We used baseline self-reported measures on mobility and health. Results: Compared to those enrolled pre-COVID-19 ( n = 61), more participants enrolled during COVID-19 ( n = 240) reported driving reductions (26% vs. 70%, p < .001) and more often for personal preference (vs. medical/emotional reasons). While mean social isolation was higher during than pre-COVID-19, self-reported depression, stress, and overall health PROMIS scores did not differ significantly. Discussion: Our findings highlight the resiliency of some older adults and have implications for mitigating the negative effects of driving cessation.
Postinfectious Acute Cerebellar Syndromes in Children: A Nationally Ascertained Case Series From Australia 2013–2018
Authors: Gunaratna Gayana P. S. , Mohammad Shekeeb S. , Blyth Christopher C. , Clark Julia , Crawford Nigel , Marshall Helen , Dale Russell C. , Jones Cheryl A. , Britton Philip N. ,   on behalf of the PAEDS network
Published: May 2022

Introduction Postinfectious acute cerebellar syndromes show a wide spectrum of acute severity and can occur with acute febrile illness or vaccine receipt. Varicella has historically been the most common cause, associated with up to 25% of cases in large cohorts. This study aimed to describe the spectrum of syndromes in a setting with high varicella vaccine coverage. Method Data were collected on children initially identified as “suspected encephalitis” subsequently designated “not-encephalitis” at participating children's hospitals in the Paediatric Active Enhanced Disease Surveillance (PAEDS) network, Australia, as part of the Acute Childhood Encephalitis study. A comprehensive descriptive analysis was undertaken on prospectively identified, national series of children with postinfectious acute cerebellar syndromes from 2013 to 2018. Cases were classified using a previously validated severity score, and the outcome was assessed at 12 months using the Liverpool Outcome Scale score. Results A total of 20 cases (65% were vaccinated for varicella) were included, of which 70% were subcategorized as acute cerebellar ataxia (ACA), 20% acute cerebellitis (AC), and 10% acute fulminant cerebellitis (AFC). An acute febrile illness was noted in 55% and none were related to varicella or were temporally related to varicella vaccination or other childhood vaccines. A subset (total of 7 children) followed up at 12 months all showed reduced Liverpool Outcome Scale scores. Discussion The study provides an overall description of this uncommon spectrum of neurologic syndromes and shows the infrequency of varicella zoster virus as a cause in a vaccinated population.
Delivery of miRNA-126 through folic acid-targeted biocompatible polymeric nanoparticles for effective lung cancer therapy
Authors: Golafzani Forough N , Vaziri Ali Z , Javanmardi Masoud , Seyfan Fatemeh , Yazdanifar Mahboubeh , Khaleghi Sepideh 
Published: May 2022

Objective: Nanoparticle-based drug delivery systems (DDSs) have been playing a considerable role in the eradication of cancer. In this experimental study, we designed and synthesized folic acid (FA)-decorated chitosan (CS) nanocarrier for targeted delivery of miR-126 (as a therapeutic agent) to lung cancer A549 cells. Materials and methods: Therefore, the FA-CS-miR-126 nano-complex was perfectly developed and characterized by various analytical devices such as Fourier transform infrared (FT-IR) and dynamic light scattering (DLS) spectroscopies and as well as transmission electron microscopy (TEM). The size was determined lower than 100 nm for synthetics. Then, a gel retardation assay was performed to investigate the entrapment efficiency of nano-complex. Afterward, the sort of in vitro assays was implemented on A549 (FA receptor-positive lung cancer cell line) and MRC5 (normal human diploid cell line) to evaluate the therapeutic efficiency of FA-CS-miR-126. Results: As the cell viability (40.7 ± 2.98% cell viability after 72 h treatment with 500 nM), migration assay (weaker migration after 24 h and 48 h), apoptotic and autophagy genes expression level (Caspse9: sixfolds; BAX: 17 folds; ATG5: fourfolds; and BECLIN1: threefolds more than the control group), the reduced expression level of EGF-L7, as a target gene for miR-126 was evaluated by Real-Time PCR too, then, cell cycle arrest (8.66% of cells in sub-G1 phase), and cell apoptosis assay (21.0% of cancer cell in late apoptosis phase) were scrutinized. Conclusion: These results are remarkably approved the biocompatible and efficient performance of FA-CS-miR-126 as a promising DDS.
Albumin-templated manganese carbonate nanoparticles for precise magnetic resonance imaging of acute myocardial infarction
Authors: Li Bing , Han Luyi , Wang Hao , Zheng Yuanyuan 
Published: May 2022

Myocardial infarction (MI) is a major cause of death worldwide. Early and precise diagnosis of myocardial viability after MI is extremely important for effective treatment and prognosis evaluation. Herein, we developed the BSA-templated manganese carbonate (MnCO3@BSA) nanoparticles as an MR imaging contrast agent for accurate detection of the infarcted regions. The chemophysical features, targeting capability toward the infarct, and biocompatibility were evaluated. The nanoparticles showed superior chemical stability. In vitro study suggested that the MnCO3@BSA nanoparticles do not enter normal cardiomyocytes. MR imaging indicated that the MnCO3@BSA with a high longitudinal ( r 1) relaxivity of 5.84 mM−1s−1 at physiological condition specifically accumulated into the infarcted regions of myocardial ischemia/reperfusion (I/R) mice. In addition, the MnCO3@BSA nanoparticles exhibited low cytotoxicity to cardiomyocytes, no damage to organs and good hemocompatibility. Thereby, the MnCO3@BSA nanoparticles manifested great potential as an extracellular contrast agent of MR imaging for sensitive and specific detection of the infarcted regions during acute myocardial I/R injury.