bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between Indonesia’s national health insurance, effective coverage in maternal health and neonatal mortality: a multilevel interrupted time-series analysis 2000–2017
Authors: Marthias Tiara , McPake Barbara , Carvalho Natalie , Millett Christopher , Anindya Kanya , Saputri Nurmala Selly , Trisnantoro Laksono , Lee John Tayu 
Published: October 2022

BackgroundWe assessed the effect of Indonesia’s national health insurance programme (Jaminan Kesehatan Nasional(JKN)) on effective coverage for maternal and child health across geographical regions and population groups.MethodsWe used four waves of the Indonesia Demographic and Health Survey from 2000 to 2017, which included 38 880 women aged 15–49 years and 144 000 birth records. Key outcomes included antenatal and delivery care, caesarean section and neonatal and infant mortality. We used multilevel interrupted time-series regression to examine changes in outcomes after the introduction of the JKN in January 2014.FindingsJKN introduction was associated with significant level increases in (1) antenatal care (ANC) crude coverage (adjusted OR (aOR) 1.81, 95% CI 1.44 to 2.27); (2) ANC quality-adjusted coverage (aOR 1.66, 95% CI 1.38 to 1.98); (3) ANC user-adherence-adjusted coverage (aOR 1.80, 95% CI 1.45 to 2.25); (4) safe delivery service contact (aOR 1.83, 95% CI 1.42 to 2.36); and (5) safe delivery crude coverage (aOR 1.45, 95% CI 1.20 to 1.75). We did not find any significant level increase in ANC service contact or caesarean section. Interestingly, increases in ANC service contact and crude coverage, and safe delivery crude coverage were larger among the poorest compared with the most affluent. No statistically significant associations were found between JKN introduction and neonatal and infant mortality (p>0.05) in the first 3 years following implementation.InterpretationExpansion of social health insurance led to substantial improvements in quality of care for maternal health services but not in child mortality. Concerted efforts are required to equitably improve service quality and child mortality across the population in Indonesia.
Assigning causality to events in the Holocene record of coral reefs
Authors: Rodriguez-Ruano Victor , Toth Lauren T. , Aronson Richard B. 
Published: October 2022

Abstract

The uncemented reef-frameworks of Pacific Panamá, which have been dominated throughout the Holocene by branching corals of the genus
Pocillopora
, experienced a hiatus in vertical accretion lasting
c.
2300 years, beginning
c.
4100 years ago. The hiatus has been attributed to an increase in variability of the El Niño–Southern Oscillation (ENSO). We tested the alternative hypothesis that the hiatus was solely the result of bioerosion, assuming an acute disturbance halted coral growth 1800 years ago (the time at which reef accretion resumed after the hiatus) and that the entire framework remained in the taphonomically active zone at that time. We calculate that it would have taken 167–511 years for bioerosion to fully remove 2300 years-worth of framework growth under those circumstances. In fact, most of the reef-framework in Panamá is stabilized in sediment that prevents the activity of bioeroders; only the upper
c.
1 m of open framework – several decades-worth of growth at most – would have been vulnerable to erosion, greatly increasing the time required to bioerode 2300 years of accumulation. We conclude that the hiatus was not solely an artefact of bioerosion; rather, a long-term increase in ENSO variability suppressed coral growth and vertical reef accretion.
Evolutionary patterns in Late Pennsylvanian conodonts
Authors: Barrick James E. , Hogancamp Nicholas J. , Rosscoe Steven J. 
Published: October 2022

Abstract

Late Pennsylvanian conodont faunas were dominated by idiognathodids historically assigned to
Idiognathodus
(flat P
1
) or
Streptognathodus
(troughed P
1
). Recent work suggests clades arose iteratively, through time, from unrelated ancestors in different geographical regions. The end-Desmoinesian extinction event terminated two major genera,
Swadelina
(troughed) and
Neognathodus
(long carina), and comparable new morphotypes developed from surviving
Idiognathodus
species in the early Kasimovian, especially in North America. True
Streptognathodus
(troughed) and
Heckelina
n. gen (asymmetric, eccentric groove) appeared in North America in the mid-Kasimovian. Another troughed clade arose in Eurasia (‘
S.
’ 2) and attained a global distribution by the late Kasimovian. A second, early Gzhelian, Eurasian radiation produced new troughed forms (‘
S.
’ 4) that dominated Gzhelian faunas globally. In South China, endemic clades of eccentrically grooved
Idiognathodus
? and troughed forms (‘
S
.’ 3) appeared in the late Kasimovian and persisted into the Gzhelian. Typical
Idiognathodus
species were uncommon by the late Kasimovian and disappeared in the mid-Gzhelian. After a low diversity interval in the mid-Gzhelian, a new major radiation of weakly troughed forms occurred (‘
S.
’ 5), which led to redevelopment of
Idiognathodus
-like elements in the Cisuralian. Other conodont genera from offshore (
Gondolella, Idioprioniodus
) and nearshore settings (
Hindeodus, Diplognathodus, Adetognathus, Ellisonia
) are poorly studied and show low diversity and little morphological change.
An Unsupervised Deep Learning-Based Model Using Multiomics Data to Predict Prognosis of Patients with Stomach Adenocarcinoma
Authors: Chen Sizhen , Zang Yiteng , Xu Biyun , Lu Beier , Ma Rongji , Miao Pengcheng , Chen Bingwei 
Published: October 2022

Object. This study is aimed at constructing a deep learning architecture of the autoencoder to integrate multiomics data and identify the risk of patients with stomach adenocarcinoma. Methods. Patients (363 in total) with stomach adenocarcinoma from The Cancer Genome Atlas (TCGA) cohort were included. An autoencoder was constructed to integrate the RNA sequencing, miRNA sequencing, and methylation data. The features of the bottleneck layer were used to perform the

k

-means clustering algorithm to obtain different subgroups for evaluating the prognosis-related risk of stomach adenocarcinoma. The model’s robustness was verified using a 10-fold cross-validation (CV). Survival was analyzed by the Kaplan-Meier method. Univariate and multivariate Cox regression was used to estimate hazard risk. The model was validated in three independent cohorts with different endpoints. Results. The patients were divided into low-risk and high-risk groups according to the

k

-means clustering algorithm. The high-risk group had a significantly higher risk of poor survival (log-rank

P

value =

2.80
e
−
06

;

adjusted

hazard

ratio
=
2.386

, 95% confidence interval: 1.607~3.543), a concordance index (C-index) of 0.714, and a Brier score of 0.184. The model performed well both in the 10-fold CV procedure and three independent cohorts from the Gene Expression Omnibus (GEO) repository. Conclusions. A robust and generalizable model based on the autoencoder was proposed to integrate multiomics data and predict the prognosis of patients with stomach adenocarcinoma. The model demonstrates better performance than two alternative approaches on prognosis prediction. The results might provide the grounds for further exploring the potential biomarkers to predict the prognosis of patients with stomach adenocarcinoma.
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Authors: Chen Hsuan-An , Ho Yu-Jui , Mezzadra Riccardo , Adrover Jose M. , Smolkin Ryan , Zhu Changyu , Woess Katharina , Bernstein Nicholas , Schmitt Georgia , Fong Linda , Luan Wei , Wuest Alexandra , Tian Sha , Li Xiang , Broderick Caroline , Hendrickson Ronald C. , Egeblad Mikala , Chen Zhenghao , Alonso-Curbelo Direna , Lowe Scott W. 
Published: October 2022

Abstract

Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune-competent liver cancer model in which senescence triggers CD8 T cell–mediated tumor rejection, we show that senescence also remodels the cell-surface proteome to alter how tumor cells sense environmental factors, as exemplified by type II interferon (IFNγ). Compared with proliferating cells, senescent cells upregulate the IFNγ receptor, become hypersensitized to microenvironmental IFNγ, and more robustly induce the antigen-presenting machinery—effects also recapitulated in human tumor cells undergoing therapy-induced senescence. Disruption of IFNγ sensing in senescent cells blunts their immune-mediated clearance without disabling the senescence state or its characteristic secretory program. Our results demonstrate that senescent cells have an enhanced ability to both send and receive environmental signals and imply that each process is required for their effective immune surveillance.

Significance:
Our work uncovers an interplay between tissue remodeling and tissue-sensing programs that can be engaged by senescence in advanced cancers to render tumor cells more visible to the adaptive immune system. This new facet of senescence establishes reciprocal heterotypic signaling interactions that can be induced therapeutically to enhance antitumor immunity.
See the interview with Direna Alonso-Curbelo, PhD, recipient of the inaugural Cancer Discovery Early Career Award: https://vimeo.com/992987447
See related article by Marin et al., p. 410.
This article is highlighted in the In This Issue feature, p. 247
Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study
Authors: Bakker Mark K. , van Straten Tijmen , Chong Michael , Paré Guillaume , Gill Dipender , Ruigrok Ynte M. 
Published: October 2022

Background:
In a genome-wide association study of intracranial aneurysms (IA), enrichment was found between genes associated with IA and genes encoding targets of effective anti-epileptic drugs. Our aim was to assess if this pleiotropy is driven by shared disease mechanisms that could potentially highlight a treatment strategy for IA.

Methods:
Using 2-sample inverse-variance weighted Mendelian randomization and genetic colocalization analyses we assessed: (1) if epilepsy liability in general affects IA risk, and (2) whether changes in gene- and protein-expression levels of anti-epileptic drug targets in blood and arterial tissue may causally affect IA risk.

Results:

We found no overall effect of epilepsy liability on IA. Expression of 21 genes and 13 proteins corresponding to anti-epileptic drug targets supported a causal effect (
P
<0.05) on IA risk. Of those genes and proteins, genetic variants affecting
CNNM2
levels showed strong evidence for colocalization with IA risk (posterior probability>70%). Higher
CNNM2
levels in arterial tissue were associated with increased IA risk (odds ratio, 3.02; [95% CI, 2.32–3.94];
P
=3.39×10
−
16
). CNNM2 expression was best proxied by rs11191580. The magnitude of the effect of this variant was greater than would be expected if systemic blood pressure was the sole IA-causing mechanism in this locus.

Conclusions:

CNNM2
is a driver of the pleiotropy between IA and anti-epileptic drug targets. Administration of the anti-epileptic drugs phenytoin, valproic acid, or carbamazepine may be expected to decrease
CNNM2
levels and therefore subsequently decrease IA risk.
CNNM2
is therefore an important target to investigate further for its role in the pathogenesis of IA.
Interactional Competence in the Heritage Language during a Study Abroad Service-Learning Program: A Case Study
Authors: Tocaimaza-Hatch C. Cecilia , Koike Dale A. 
Published: October 2022

Abstract
This case study describes the interactional competence of one U.S. Spanish heritage language learner (HLL), during a five-week study abroad program in Spain that included service-learning. Data were drawn primarily from audiotapes, reflection essays, and an exit interview. The audiotapes included “Mía’s” conversations at the service-learning site, a summer camp for young children. The three resource categories in Young’s (2019) model of Practice Theory of identity, linguistic, and interactional resources facilitated the analysis of Mía’s intercultural competence.
The qualitative analysis describes, first, Mía’s resources during discursive practices with children and peer teachers at the camp, reflecting the construction of her identity as an educator. Second, we examine possible connections between Mía’s resources and her Spanish learning history. We show that the linguistic and interactional resources observed in her interactions are congruent with her HLL background, as seen in her lexical choices and flexibility interacting with diverse interlocutors. These findings of one HLL’s linguistic activity shed light on her interactional competence in this context, thus contributing to the literature on HLL s in study abroad.
Traditional and Religious Approaches as Psychosocial Support in the Reintegration of Former Girl Soldiers in South Sudan
Authors: Jangaling Lujang John , Sidhu Jatswan S. 
Published: October 2022

Abstract
The major cause of the conflict in South Sudan was power struggles among the political elites who manipulated ethnic differences along tribal lines. In the case of defunct Gbudue State both Sudan People Liberation Army in Opposition (SPLAIO) and South Sudan National Liberation Movement (SSNLM) massively recruited girl soldiers into their ranks. After the conflict, the girl soldiers returned home with deep psychosocial effects. The conflict has brought to fore existence of rich knowledge of traditional and religious approaches in reintegration process. This article attempts to examine the significance of traditional approaches used as psychosocial support during reintegration of former girl soldiers and analyse the extent of religion as dominant approach during the reintegration of former girl child soldiers in South Sudan. The article was guided by Instrumentalist theory: Elite Perspective. The study revealed both traditional approaches and religion in form of prayers helped psychologically to reintegrate former girl soldiers into the communities. The study also revealed that reintegration is a process that aims to reintegrate former girl soldiers within their families, economically and socially. From a methodological point of view, this article is a phenomenologically designed with findings include discussions about themes and patterns discovered during data analysis.
A Theological Case for Ukraine’s European Integration: Deconstructing the Myth of “Holy Russia” versus “Decadent Europe”
Authors: Searle Joshua T. 
Published: October 2022

Abstract
The overall aim of this article is to make a theological case for Ukraine’s integration into the European family of nations. I build this case by pursuing two primary lines of argument: firstly, by demonstrating the implausibility of the common assumptions (held by many Ukrainian Christians) that Russia is more ‘spiritual’ and ‘Christian’ than ‘secular’ and ‘godless’ Europe. Secondly, I seek to make a positive case for why principles, such as human dignity and human rights, cultural diversity, democracy, justice, fairness, equality and the rule of law, are much more appropriate indicators of Christian values than nominal allegiance to religious institutions among a certain population. This article is divided into three parts. Part One identifies and critiques the salient features of the “Holy Russia” myth with illustrations drawn from various representative figures. Part Two is devoted to the defence of the European tradition in which I advance the counterintuitive argument that secular liberalism is more in continuity with orthodox Christianity than Christian nationalism. In Part Three, I apply these general points to the specific issue of Ukraine and its fate as a European nation.
The Case for Removing the Security Council’s Powers from the International Criminal Court
Authors: Yigzaw Destaw A. 
Published: October 2022

Abstract
The Singapore compromise was the basis for the role of the United Nations Security Council (unsc) in the operations of the International Criminal Court (icc). The compromise was meant to enlist the support of superpowers. Yet, three of the five permanent members of the unsc; namely, China, Russia, and the United States have not only stayed out of the Rome Statute system but also have taken turns in undermining the icc. Thus, the political power they enjoy over the icc– an institution they refuse to recognize–defies elementary requirements of legitimacy. Crucially, the lack of consensus in the unsc due to growing big power confrontations means that it has been unable to make referrals for over a decade. The price the icc pays in terms of its independence and legitimacy due to its association with the unsc is thus for little gain.
The Personal is Political
Authors: Annin Felicia 
Published: October 2022

Abstract
In this article, I posit that Ngũgĩ’s oeuvre presents numerous instances of love, betrayal, and adultery. While love and adultery are limited to personal spaces, betrayal occurs in both the personal and political spheres in Ngũgĩ’s works. In the novel A Grain of Wheat, betrayals in the personal sphere are juxtaposed with betrayals in the political sphere. The betrayal within the political sphere has implications for the personal relations of the characters. Political ideals are betrayed by the complex and divided characters in Ngũgĩ’s narratives. The characters are not spared betrayal on personal and political levels. The personal and political betrayals thus are conflated and make it a critical area of study. This study seeks to emphasise that both forms of betrayal are crucial and the relationship between them is inseparable. The personal betrayal in Ngũgĩ’s A Grain of Wheat (1967) occurs in romantic relationships; more specifically, the betrayal is represented by adultery in marriage, while the political betrayal emerges as betraying one’s country.
The Fabrics of Home: Remembering the Indo-European Repatriation in Contractpensions-Djangan Loepah!
Authors: Arps Arnoud 
Published: October 2022

Abstract
When a large group of Indo-Europeans had to repatriate to a country many had never set foot in, they set in motion an unforeseen culture of remembrance. The subsequent narratives of forced migration – or rather narratives of belonging – deal with memories of home. Whereas first-generation repatriates predominantly used literature to document their memories, the second-generation remembers the past in the cinematic field of the cultural imaginary. Focusing on the documentary Contractpensions by a second-generation Indo-European, this article explores representations of the repatriate Indo-European experience and the relation between the current country in which they reside and the homeland of earlier generations. Of particular significance are the tensions between geographical attachment, their repatriate identity, and a brittle Dutch nationality. The article argues that the idea of home is central to these tensions, and that place, belonging and citizenship are the threads of home that weave Indo-European repatriate culture and identity into being.
Civic Service and the Question of Extra-Military Missions of the Army in Franco-Ivorian Military Relations (1960–1970)
Authors: Banga Arthur 
Published: October 2022

Abstract
With a negotiated decolonisation and a steadfast friendship between Félix Houphouët-Boigny and General Charles de Gaulle, Côte d’Ivoire, which had become independent, maintained excellent relations with France, its former colonial power. These close relations allowed it to benefit, within the framework of the Franco-Ivorian cooperation agreements, from French military assistance in setting up its armed forces. With this help, the Ivorian Army and Gendarmerie were thus taking their first steps under France’s military leadership. But divergences appeared at certain levels and the question of extra-military tasks or, more precisely, the importance granted to them in the missions of the Ivorian Armed Forces was the subject of heated debates between the two partners. The crux of the issue was the establishment and development of the Ivorian Civic Service, for which Abidjan had turned to Israel in the belief that this would not jeopardise French influence in the Ivorian defence establishment. This article revisits this issue by highlighting the intricacies and challenges in the creation of the Ivorian Civic Service.
Preliminary Exploration of Training, Perspectives, and Mental Health Program Awareness in Slaughter Plant Workers Who Perform Stunning as Part of Their Job
Authors: Edwards-Callaway Lily N. , Mijares Sage H. , Simpson Hailey M. , Cramer Mary Caitlin , Román-Muñiz Ivette Noa , Stallones Lorann 
Published: October 2022

Abstract
Stunning livestock (rendering them unconscious) is a necessary component of initiating humane slaughter, thus it is important to provide support to individuals performing this job. The objective of this study was to identify worker perspectives, training methods, and resources available to workers performing stunning. An online survey was distributed to industry association listservs or direct emails of slaughter plants in the United States of America. An additional survey was administered at an industry conference to increase participation. Twenty respondents completed the slaughter survey. Respondents were commonly trained using an in-person, in-house trainer. Respondents indicated feeling confident in performing stunning after training (18, 90%) and that “stunning animals has become easier the more times they did it” (17, 85%). Only 2 (10%) respondents said there were aware of programs to promote mental health, but most (17, 85%) felt “supported by peers in their workplace.” This preliminary survey identified interest in more training and limited awareness of supportive resources.
Navigating Alcogenic Brand Environment: Exploring How Young Nigerians Negotiate and Make Sense of Alcohol Brand Preferences
Authors: Dumbili Emeka W. , Uwa-Robinson Kelechi 
Published: October 2022

No previous research has examined how and why Nigerians choose their alcohol brands. Using qualitative data, this study explored brand preference and the reasons for brand choice among 18 to 24 year-old Nigerians who use alcohol. Participants were divided into three categories based on their beer, spirit, and wine preferences. While most men preferred beer and spirits, many women chose traditional and recently developed flavoured beers and spirit-based drinks, which the alcohol industry promotes as women-friendly alcoholic drinks. Some participants chose low-strength brands to avoid heavy drinking and intoxication, while others preferred high-strength brands for immediate bodily thrills/intoxication. Some participants preferred expensive brands to cheaper beverages to construct social identity and portray an affluent lifestyle, while others used the consumption of ‘foreign’ or uncommon brands to enact distinction. Alcohol advertising and peer influence significantly impacted brand awareness and preferences. Interventions should focus on reducing alcohol/brand availability and accessibility in Nigeria.