bluuebunny/crossref_metadata_2025_split huggingface dataset:
COX‐2 inhibitors show no preventive effect in the development of skin cancer
Authors: Yen Hsuan , Yen Hsi , Drucker Aaron M. , Han Jiali , Li Wen‐Qing , Li Tricia , Qureshi Abrar , Cho Eunyoung 
Published: January 2022

SummaryBackgroundSome clinical trials found that cyclooxygenase‐2 (COX‐2) inhibitor use lowered the risk of skin cancer in high‐risk groups.Patients and MethodsTo determine whether COX‐2 inhibitor use is associated with lower risk of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and melanoma, we analyzed COX‐2 inhibitor use and risk of skin cancer based on three prospective cohort studies, the Nurses’ Health Study (NHS), NHS II, and the Health Professionals Follow‐up Study, including 153,882 participants. Multivariable hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association of COX‐2 inhibitor use with risk of BCC, cSCC, and melanoma were estimated using Cox proportional hazards models. We pooled the results using a fixed effects model.Results16,142 BCC, 1,973 cSCC, and 631 melanoma cases were documented. Ever vs. never use of COX‐2 inhibitor was associated with a modestly increased risk of BCC (multivariable HR 1.09, 95 % CI 1.05–1.14). The hazard ratio was similar for cSCC (multivariable HR 1.12, 95 % CI 1.00–1.27) and melanoma (multivariable HR 1.10, 95 % CI 0.89–1.38), but was not statistically significant.ConclusionsEver use of COX‐2 inhibitor was not associated with a decreased skin cancer risk but was instead associated with a modest, increased risk of BCC.
Empowering young Aboriginal women to care for Country: Case study of the Ngukurr Yangbala rangers, remote northern Australia
Authors: Daniels Cherry Wulumirr ,   Ngukurr Yangbala rangers, Russell Shaina , Ens Emilie J. 
Published: January 2022

SummaryGlobally, the role of women in conservation is gaining attention with increasing initiatives to support gender equity in environmental management and decision‐making. In Australia, the role of Aboriginal women in natural and cultural resource management employed as rangers is also gaining recognition; however, female employment in this field remains underrepresented. This paper reflects on a cross‐cultural partnership aimed at empowering young Aboriginal women in natural and cultural resource management, locally known as caring for Country, in Arnhem Land, a remote Aboriginal owned region of northern Australia. The project was led by local Ngukurr community Ngandi Elder and lead author, Mrs Daniels, and Macquarie University researchers who co‐designed and co‐delivered activities according to five project aims: (i) Community involvement; (ii) Biocultural research / learning on Country; (iii) Leadership and confidence building; (iv) Knowledge maintenance; and (v) Capacity building. Over three years of the project, over 60 youth participated in a range of on‐Country and cultural learning, leadership and capacity building activities including cross‐cultural biodiversity surveys, wetland monitoring, traditional language and knowledge recording and culture camps. Participant feedback and a biocultural learning assessment task noted growth in confidence, biocultural knowledge and desire for continuation of youth empowerment programs in conservation. To facilitate gender equity in Aboriginal natural and cultural resource management, structural and sustained support of women’s empowerment and leadership, driven by local women with support of local communities, is required.
Biomarkers for predicting nucleos(t)ide analogs discontinuation and hepatitis B virus recurrence after drug withdrawal in chronic hepatitis B patients
Authors: Luo Mengqi , Zhou Bin , Hou Jinlin , Jiang Deke 
Published: January 2022

AbstractAimTo summarize HBV‐related biomarkers predicting nucleos(t)ide analogs (NAs) discontinuation and hepatitis B virus (HBV) recurrence after drug withdrawal in chronic hepatitis B (CHB) patients, providing references for clinical medication, so as to manage CHB patients more scientifically.MethodsRelated pieces of literature were retrieved in PubMed and the results were sorted out. We then analyzed and summarized these articles.ResultsWe found that HBV related biomarkers maybe could predict NAs withdrawal safely and the possibility of relapse after treatment cessation, including hepatitis B e antigen (HBeAg), hepatitis B surface antigen (HBsAg), HBV DNA, HBV RNA, pregenomic‐RNA (pgRNA), hepatitis B core‐related antigen (HBcrAg), hepatitis B core antibody (anti‐HBc), and models containing several indicators for predicting the effectiveness of treatment.ConclusionsHBV DNA, HBV RNA, pgRNA, HBcrAg, anti‐HBc, as well as the prediction models formed by several biomarkers could predict the safe discontinuation of NAs before HBsAg loss and recurrence.
Comparison of the postoperative anti‐inflammatory efficacy of chlorhexidine, saline rinses and herbal mouthwashes after mechanical debridement in patients with peri‐implant mucositis: A randomized controlled trial
Authors: Alqutub Montaser N. , Alhumaidan Abdulkareem A , Alali Yasser , Al‐Aali Khulud A , Javed Fawad , Vohra Fahim , Abduljabbar Tariq 
Published: January 2022

AbstractAimThe null hypothesis is that there is no difference in the post‐operative anti‐inflammatory efficacy of chlorhexidine (CHX), 2% saline rinses (SR) and a herbal mouthwash (MW) after non‐surgical mechanical debridement (MD) for treatment of peri‐implant mucositis (PiM). The aim was to compare the post‐operative anti‐inflammatory efficacy of CHX, 2% SR and a herbal oral rinse after non‐surgical MD of PiM.Materials and MethodsThe present randomized controlled trial had a single‐blinded parallel arm design. Patients diagnosed with PiM were enrolled. Demographic information was recorded. All patients underwent MD and were randomly divided into 4 groups: CHX‐group: 0.12% non‐alcoholic CHX; Sodium chloride (NaCl) group: 2% NaCl rinses; Herbal MW group: Herbal‐based MW and H2O group: distilled water with peppermint flavour. After MD, all the participants were advised to rinse twice daily (every 12 hrs) for 2 weeks with their respective MWs. In all groups, peri‐implant modified plaque index (mPI), modified gingival index (mGI) and probing depth (PD) were measured at baseline and at 12 weeks of follow‐up. Sample size was estimated using data from a pilot investigation; and group‐comparisons were performed. Statistical significance was confirmed when P‐values were below 0.01.ResultsSixty individuals (15 patients/group) were included. At baseline, mPI, mGI and PD were comparable in all groups. At baseline, there was no significant difference in peri‐implant mPI, mGI and PD in all groups. At 12‐weeks’ follow‐up, there was a statistically significant reduction in peri‐implant mPI (p < 0.01), mGI (p < 0.01) and PD (p < 0.01) in CHX, NaCl and herbal MW groups compared with H2O group. There was no significant relation between implant location, duration for which, implants were functional, gender and peri‐implant clinical parameters in all groups.ConclusionAfter non‐surgical MD, post‐operative use of CHX and herbal and NaCl MWs is useful for the management of PiM in the short‐term.
Risk indicators of long‐term outcome of implant therapy in patients with a history of severe periodontitis or no history of periodontitis: A retrospective cohort study
Authors: Alhakeem Mohammed , Kanounisabet Negar , Nowzari Hessam , Aslroosta Hoori , Moslemi Neda 
Published: January 2022

AbstractObjectiveThe aim of this retrospective cohort study was to assess factors associated with peri‐implant disease in partially edentulous patients with a history of severe periodontitis or no history of periodontitis.MethodsPartially edentulous patients with a history of severe periodontitis/without history of periodontitis who received implant surgery within the past 6 to 8 years were recalled. Clinical and radiographic examinations were recorded. Periodontal probing depth, marginal bone loss (MBL) and peri‐implantitis were considered as the primary outcome and peri‐implant bleeding on probing (BOP) was considered as the secondary outcome. The following criteria were considered as the predictors, as well: history of severe periodontitis, gender, age, smoking, brushing frequency, recall interval, full‐mouth plaque score, full‐mouth bleeding score, splinted prosthesis, open/tight interproximal contact, width of keratinized mucosa, mucosal thickness, implants placed in the grafted bone and implant type. Univariate and multivariate regression analyses were utilized.ResultsA total of 88 patients (186 implants) fulfilled the study. Forty‐seven patients (108 implants) had a history of severe periodontitis and 41 patients (78 implants) had no history of periodontitis. There was a higher chance of peri‐implantitis in patients with a history of severe periodontitis (OR = 11.13; p = 0.045), implants with lack of peri‐implant KM (<2 mm) and implants placed in the grafted bone (OR = 14.94, p < 0.001; OR = 4.93, p = 0.047). The risk of peri‐implant MBL ≥3 mm was higher in patients with greater FMBS (OR = 1.20; p < 0.001). The chance of peri‐implant BOP was independently higher in patients who brushed their teeth at most once per day (OR = 3.20; p = 0.04), higher FMBS (OR = 1.16; p < 0.001) and irregular recall visits (OR = 15.34; p = 0.001).ConclusionsPartially edentulous patients with the history of severe periodontitis, lack of peri‐implant KM and implants placed in bone‐grafted sites expressed higher probability of peri‐implantitis. In addition, inadequate frequency of brushing (at most once daily) and irregular recall visits were associated with greater chance of peri‐implant BOP.
Exploring responses to differing message content of pictorial alcohol warning labels
Authors: Hassan Louise M. , Parry Sara , Shiu Edward 
Published: January 2022

AbstractOne way of tackling hazardous alcohol consumption is introducing warning labels on alcohol products. This research explores three under‐researched message content areas in relation to alcohol warning labels: negative/positive framing of the message; use of signal words and qualifiers and type of information used in the message (qualitative or quantitative), across message themes that depict social or health consequences. A qualitative and exploratory approach was undertaken using five focus groups of UK undergraduate students followed by 15 semi‐structured interviews with UK adults. Discussions centred around responses to the alcohol warning labels that varied in message content characteristics. The students also created their own warning label designs based on what they believed would be useful for encouraging students to keep to low‐risk drinking guidelines. Findings across both samples revealed a preference for negatively (loss) framed health messages that elicit fear and use evidence‐based reasoning and statistics. The avoidance of signal words (e.g. ‘government warning’) and qualifiers (e.g. may cause) would likely make the messages more persuasive. Our findings contribute to understanding the influence of message content on consumer responses to alcohol warning labels. However, such message content characteristics are inherent in the design of many product warnings and our findings may apply to other contexts.
Women's fertility decision‐making with a diagnosis of breast cancer: A qualitative evidence synthesis
Authors: Linnane Sharon , Quinn Aoife , Riordan Anne , Dowling Maura 
Published: January 2022

AbstractAimTo synthesize qualitative evidence of premenopausal women's experiences of fertility decision‐making with a diagnosis of breast cancer.BackgroundBreast cancer is increasingly more common in premenopausal women who may have not yet considered starting a family or have completed their families.DesignQualitative evidence synthesis guided by Thomas and Harden's three‐stage approach to thematic analysis.Data SourcesTwelve electronic databases were searched: CINAHL, Embase, Pubmed, Proquest, PsychINFO, Lenus, Scopus, Web of Science, Rian.ie, Medline, EThOS e‐theses online and DART Europe. No year limit was set.Review MethodsThe ‘Enhancing transparency in reporting the synthesis of qualitative research guidelines’ (ENTREQ) statement was followed.ResultsFifteen qualitative studies were included in the synthesis. Seven review findings under four major themes were identified: (1) first comes survival, (2) making decisions ‘under the gun’, (3) health‐care professionals should not make assumptions and (4) we want accurate, detailed information and we want it early. High confidence in six of the review findings was agreed.ConclusionMost women experienced rushed fertility preservation decision‐making at a time when they also faced cancer treatment decisions. Women want detailed, clear information on fertility preservation early after their diagnosis.
Evaluation of incontinence women aged 20 or older living in Diyarbakir
Authors: Yakit Ak Eda , Oskay Umran 
Published: January 2022

AbstractThis study aimed to determine whether women aged 20 or older living in the city of Diyarbakir had urinary incontinence or not. The study was carried out with a total of 410 women. The research data were collected between December 2017 and March 2018. As the data collection tool, a questionnaire form developed in line with the related literature, Bristol female lower urinary tract symptoms (BFLUTS) questionnaire and healthy lifestyle behaviours scale (HLBS II) were used. The women had an average age of 35.86 ± 10.98. Of all the women, 66.9% of them had complaints of urinary incontinence, and 48.9% suffered from Stress UI. The total BFLUTS scores increased at older ages. However, this result was not found statistically significant (p > 0.05). A significant relationship was found between the BFLUTS scores and being 40 or older, giving birth or more than one birth, chronic disease, BMI > 25, frequent urinary tract infection and gynaecological surgery (p < 0.05). There was no statistically significant difference between UI and the HLBS II results (p > 0.05). The results of multi regression analysis revealed a significant relationship between UI and giving birth (p < 0.05), yet no relationship was found between other risk factors (p > 0.05). UI is quite a common problem, which is not considered important, though. In the present study, being older than 40, giving birth and giving birth twice or more, having a chronic disease, BMI > 25, frequent urinary tract infection and gynaecological surgery were all influential on UI. Giving birth seemed to be the determiner of UI.
Long‐term predialysis blood pressure variability and outcomes in hemodialysis patients
Authors: Yang Jingjuan , Huang Jian , Yu Biying , Zhang Qian , Zhang Shanshan , Wu Longlong , Luo Lin , Li Lizhu , Li Li , Han Fei , Lai En Yin , Yang Yi 
Published: January 2022

AbstractBlood pressure variability (BPV) is significantly associated with cardiovascular diseases (CVD) and mortality in hemodialysis patients. However, the relationship between blood pressure and CVD in hemodialysis patients is complex and affected by many factors. The present study aimed to assess the association of long‐term predialysis BPV with all‐cause mortality and major adverse cardiovascular events (MACE). One thousand seven hundred twenty‐seven patients receiving maintenance hemodialysis were recruited in nine hemodialysis centers. Predialysis BPV was assessed over 1‐year intervals. Outcomes included all‐cause mortality and MACE during follow‐up periods. The mean age of the final cohort was 59 years, of which 57% were males. Greater predialysis systolic BPV was associated with an increased risk of all‐cause mortality (adjusted hazard ratio, 1.101; 95% confidence intervals 1.064–1.140) and MACE (adjusted hazard ratio, 1.091; 95% confidence intervals 1.059–1.125). Results were similar when systolic BPV was stratified by baseline systolic blood pressure. In conclusion, greater predialysis BPV among hemodialysis patients was associated with all‐cause mortality and MACE. Strategies to reduce blood pressure variability might be beneficial for hemodialysis patients.
Wharton’s jelly‐derived stromal cells and their cell therapy applications in allogeneic haematopoietic stem cell transplantation
Authors: Pochon Cécile , Notarantonio Anne‐Béatrice , Laroye Caroline , Reppel Loic , Bensoussan Danièle , Bertrand Allan , Rubio Marie‐Thérèse , D’Aveni Maud 
Published: January 2022

AbstractFor decades, mesenchymal stromal cells (MSCs) have been of great interest in the fields of regenerative medicine, tissue engineering and immunomodulation. Their tremendous potential makes it desirable to cryopreserve and bank MSCs to increase their accessibility and availability. Postnatally derived MSCs seem to be of particular interest because they are harvested after delivery without ethical controversy, they have the capacity to expand at a higher rate than adult‐derived MSCs, in which expansion decreases with ageing, and they have demonstrated immunological and haematological supportive properties similar to those of adult‐derived MSCs. In this review, we focus on MSCs obtained from Wharton's jelly (the mucous connective tissue of the umbilical cord between the amniotic epithelium and the umbilical vessels). Wharton's jelly MSCs (WJ‐MSCs) are a good candidate for cellular therapy in haematology, with accumulating data supporting their potential to sustain haematopoietic stem cell engraftment and to modulate alloreactivity such as Graft Versus Host Disease (GVHD). We first present an overview of their in‐vitro properties and the results of preclinical murine models confirming the suitability of WJ‐MSCs for cellular therapy in haematology. Next, we focus on clinical trials and discuss tolerance, efficacy and infusion protocols reported in haematology for GVHD and engraftment.
Living and working environments are important determinants of glycemic control in patients with diabetes during the COVID‐19 pandemic: A retrospective observational study
Authors: Terakawa Aiko , Bouchi Ryotaro , Kodani Noriko , Hisatake Tomoko , Sugiyama Takehiro , Matsumoto Michihiro , Ihana‐Sugiyama Noriko , Ohsugi Mitsuru , Ueki Kohjiro , Kajio Hiroshi 
Published: January 2022

AbstractAimTo investigate (1) the association of lifestyle changes and living and working conditions with glycemic control and (2) whether treatment was intensified appropriately in patients with diabetes under the first COVID‐19 state of emergency in Japan.Materials and MethodsA total of 321 participants were included. Participants completed a questionnaire regarding lifestyle changes, including diet, physical activity, and living and working conditions during the COVID‐19 pandemic. The change in hemoglobin A1c (HbA1c) levels was estimated before (June 1, 2019 to August 31, 2019) and during (June 1, 2020 to August 31, 2020) the pandemic. Factors associated with changes in HbA1c levels were examined by multiple linear regression analysis. The proportion of patients who received treatment intensification for diabetes was compared between before and during the pandemic.ResultsThere was no significant change in HbA1c levels before the pandemic and during the pandemic (7.13 ± 0.98% vs 7.18 ± 1.01%, P = 0.186). Teleworking (estimate 0.206, P = 0.004) and living with a dog (estimate −0.149, P = 0.038) were significantly associated with changes in HbA1c levels after adjusting for covariates. There was no significant difference in the proportion of patients who received treatment intensification for diabetes during the pandemic and before the pandemic in either the elderly or non‐elderly patients.ConclusionsOverall glycemic control did not worsen during the pandemic. Nonetheless, environmental factors, including telework, were found to influence glycemic control in patients with diabetes. Further studies are needed to clarify whether the COVID‐19 pandemic could affect treatment intensification for diabetes.
Evidence‐basing for quality improvement; bringing clinical practice guidelines closer to their promise of improving care practices
Authors: Moleman Marjolein , Jerak‐Zuiderent Sonja , van de Bovenkamp Hester , Bal Roland , Zuiderent‐Jerak Teun 
Published: January 2022

AbstractBackgroundClinical practice guidelines (CPGs) have become central to efforts to change clinical practice and improve the quality of health care. Despite growing attention for rigorous development methodologies, it remains unclear what contribution CPGs make to quality improvement.AimThis mixed methods study examines guideline quality in relation to the availability of certain types of evidence and reflects on the implications of CPGs' promise to improve the quality of care practices.MethodsThe quality of 62 CPGs was assessed with the Appraisal of Guidelines, Research, and Evaluation (AGREE) instrument. Findings were discussed in 19 follow‐up interviews to examine how different quality aspects were considered during development.ResultsThe AGREE assessment showed that while some quality criteria were met, CPGs have limited coverage of domains such as stakeholder involvement and applicability, which generally lack a ‘strong’ evidence base (e.g., randomized controlled trials [RCT]). Qualitative findings uncovered barriers that impede the consolidation of evidence‐based guideline development and quality improvement including guideline scoping based on the patient‐intervention‐comparison‐outcome (PICO) question format and a lack of clinical experts involved in evidence appraisal. Developers used workarounds to include quality considerations that lack a strong base of RCT evidence, which often ended up in separate documents or appendices.ConclusionFindings suggest that CPGs mostly fail to integrate different epistemologies needed to inform the quality improvement of clinical practice. To bring CPGs closer to their promise, guideline scoping should maintain a focus on the most pertinent quality issues that point developers toward the most fitting knowledge for the question at hand, stretching beyond the PICO format. To address questions that lack a strong evidence base, developers actually need to appeal to other sources of knowledge, such as quality improvement, expert opinion, and best practices. Further research is needed to develop methods for the robust inclusion of other types of knowledge.
Comparing the effectiveness of Cinnamomum zeylanicum essential oil and two common household sanitizers to reduce lettuce microbiota and prevent Salmonella enterica recontamination
Authors: Rossi Chiara , Maggio Francesca , Casaccia Manila , Chaves‐López Clemencia , Valbonetti Luca , Serio Annalisa , Paparella Antonello 
Published: January 2022

AbstractThe washing step is necessary to remove biological and physical hazards from minimally processed vegetables. Nevertheless, the risk of foodborne diseases could persist even after washing due to postsanitizing contamination, and little is known about the antimicrobial effect of residual sanitizers. This study was conducted to compare the effectiveness of sodium hypochlorite (SH), sodium bicarbonate, and Cinnamomum zeylanicum essential oil (CEO) as sanitizers on lettuce (8°C, 48 h). First, the effect of sanitizers in reducing total aerobic mesophilic and psychrotrophic bacteria, yeast and molds, lactic acid bacteria, and Enterobacteriaceae on lettuce was evaluated with some insights on lettuce quality attributes (pH, color, and sensory analysis). Then, the capability of the treatments in preventing postwashing Salmonella adhesion on lettuce surface was investigated. Commercial SH disinfectant (solution at 2%) and CEO (0.5%) reduced microbial contamination in lettuce, without affecting the overall acceptability after 48 h at 8°C. SH reduced postsanitizing Salmonella adhesion of about 2.7 Log colony forming unit (CFU)/g. The microbial reduction was confirmed by confocal laser scanning microscopy, which also evidenced Salmonella internalization within stomata. Interestingly, CEO as well reduced Salmonella adhesion but with lower efficacy (0.44–1.00 Log CFU/g reduction), while sodium bicarbonate (15 mg/ml) was not effective. In conclusion, SH and CEO seem to be effective sanitizing agents, capable of improving the microbiological profile of fresh produce. In addition, the residual sanitizers, that remain on lettuce after washing, play a role in reducing Salmonella adhesion.