bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Model Predictive Control of Floating Offshore Wind Turbines With Artificial Muscle Actuated Mooring Lines
Authors: Wu Zhongyou , Li Yaoyu 
Published: January 2022

Abstract
Floating offshore wind turbines (FOWTs) are subject to undesirable platform motion and a significant increases in fatigue loads compared to their onshore counterparts. We have recently proposed using the fishing line artificial muscle (FLAM) actuators to realize active mooring line force control (AMLFC) for platform stabilization and thus load reduction, which features a compact design and no need for turbine redesign. However, as for the thermally activated FLAM actuators, a major control challenge lies in the asymmetric dynamics for the heating and the cooling half cycle of operation. In this paper, for a tension-leg platform (TLP) based FOWT with FLAM actuator based AMLFC, a hybrid dynamic model is obtained with platform pitch and roll degrees-of-freedom included. Then a hybrid model predictive control (HMPC) strategy is proposed for platform motion stabilization, with preview information on incoming wind and wave. A move blocking scheme is used to achieve reasonable computational efficiency. Fatigue, aerodynamics, structures, and turbulence (FAST) based simulation study is performed using the National Renewable Energy Laboratory (NREL) 5 MW wind turbine model. Under different combinations of wind speed, wave height and wind directions, simulation results show that the proposed control strategy can significantly reduce the platform roll and tower-base side-to-side bending moment, with a mild level of actuator power consumption.
Precise Position Adjustment of Automotive Electrohydraulic Coupling System With Parameter Perturbations
Authors: Mei Mingming , Cheng Shuo , Li Liang , Yan Bingjie 
Published: January 2022

Abstract
Based on the guaranteed cost theory, this paper proposes a robust controller for the automotive electrohydraulic coupling system. However, parameter perturbation caused by the model linearization is a critical challenge for the nonlinear electrohydraulic coupling system. Generally, the electrical brake booster system (E-booster) can be separated into three parts, a permanent magnet synchronous motor (PMSM), a hydraulic model of the master cylinder, and the transmission mechanism. In this paper, the robust guaranteed cost controller (RGCC) is adopted to achieve an accurate regulation of the pushrod position of the E-booster and has strong robustness against internal uncertainties, and the linear extended state observer (LESO) is utilized to optimize E-booster's dynamic performance. Specifically, the tracking differentiator (TD) and LESO are used to improve the dynamic precision and reduce the hysteresis effect. The overshoot is suppressed by TD, and the disturbance caused by nonlinear uncertainty is restrained by LESO. The experimental results show that RGCC sacrifices a 6% phase lag in the low-frequency domain for a 10% and 40% reduction in first and second-order, respectively, compared with the proportion integration differentiation (PID). Results demonstrate that RGCC has higher precision and stronger robustness in dynamic behavior.
Algebraic Driver Steering Model Parameter Identification
Authors: Wang Zejiang , Zhou Xingyu , Shen Heran , Wang Junmin 
Published: January 2022

AbstractModeling driver steering behavior plays an ever-important role in nowadays automotive dynamics and control applications. Especially, understanding individuals' steering characteristics enables the advanced driver assistance systems (ADAS) to adapt to particular drivers, which provides enhanced protection while mitigating human–machine conflict. Driver-adaptive ADAS requires identifying the parameters inside a driver steering model in real-time to account for driving characteristics variations caused by weather, lighting, road, or driver physiological conditions. Usually, recursive least squares (RLS) and Kalman filter are employed to update the driver steering model parameters online. However, because of their asymptotical nature, the convergence speed of the identified parameters could be slow. In contrast, this paper adopts a purely algebraic perspective to identify parameters of a driver steering model, which can achieve parameter identification within a short period. To verify the proposed method, we first apply synthetic driver steering data to show its superior performance over an RLS identifier in identifying constant model parameters, i.e., feedback steering gain, feedforward steering gain, preview time, and first-order neuromuscular lag. Then, we utilize real measurement data from human subject driving simulator experiments to illustrate how the time-varying feedback and feedforward steering gains can be updated online via the algebraic method.
Joint Analysis and Reliability Test of Epoxy-Based Nano Silver Paste Under Different Pressure-Less Sintering Processes
Authors: Wang Xinyue , Zeng Zejun , Zhang Guoqi , Zhang Jing , Liu Pan 
Published: January 2022

Abstract
Recent years, the sintered silver paste was introduced and further developed for power electronics packaging due to low processing temperature and high working temperature. The pressure-less sintering technology reduces the stress damage caused by the pressure to the chip, improves reliability, and is widely applied in manufacturing. Currently, most existed studies are focused on alcohol-based sintered silver pastes while resins have been demonstrated to improve the bonding properties of solder joints. Hence, the performance and sintering mechanisms with epoxy-based silver paste need to be further explored. In this work, a methodology for multifactor investigation is settled on the epoxy-based silver paste to reveal the relationship between the strength and the different influence factors. We first analyzed the characteristics of commercialized epoxy-based silver paste samples, including silver content, silver particle size, organic composition, sample viscosity, and thermal conductivity. Samples were then prepared for shear tests and microstructure analysis under different pressure-less sintering temperatures, holding time, substrate surface, and chip size. Full factor analysis results were further discussed in detail for correlation. The influence factors were ranked from strong to weak as follows: sintering temperature, substrate surface, chip size, and holding time. Finally, a thermal cycling test was carried out for reliability analysis. Epoxy residues are one of the possible reasons, which result in shear strength decreasing exponentially.
Opportunities in Nano-Engineered Surface Designs for Enhanced Condensation Heat and Mass Transfer
Authors: Ho Jin Yao , Rabbi Kazi Fazle , Khodakarami Siavash , Ma Jingcheng , Boyina Kalyan S. , Miljkovic Nenad 
Published: January 2022

AbstractRecent advancements in surface nano-engineering have spurred intense interests in their implementation for enhancing condensation heat transfer. When appropriately designed, nano-engineered surfaces not only lead to highly efficient transport mechanisms not achievable with conventional dropwise condensation (DWC), they also demonstrate the possibility of augmenting condensation of low surface tension fluids widely used in industry. These advantages are further enhanced by the development of highly scalable nanofabrication methods, which enable the potential transition from laboratory-scale prototypes to real-world industrial applications. In this review, we discuss the progress, opportunities, and challenges of enhancing condensation heat and mass transfer with nano-engineered surfaces. This article provides an overview of the recent developments in micro/nanoscale coating and structure fabrication techniques and performs a thorough comparison of their condensation performance, elucidating the complex interfacial transport mechanism involved. Surface structuring methods that are durable, scalable, and low-cost are essential attributes for large-scale industrial implementation. Here, the methods used to improve surface durability and demonstrations of nanostructure-enhanced meter-scale condensers are presented. Limitations are discussed and the potential techniques to overcome these challenges are summarized. Given the recent development of metal additive manufacturing (AM) technology and its growing relevance in manufacturing processes, we end this review by providing our perspectives on the opportunities in enabling surface nanostructuring of metal additive manufactured materials and the potential of nanometric–millimetric codesign optimization for the development of next-generation additively manufactured condensers.
Bending Stiffness of Circular Multilayer van der Waals Material Sheets
Authors: Ma Xiaojie , Liu Luqi , Zhang Zhong , Wei Yueguang 
Published: January 2022

Abstract
We study the bending stiffness of symmetrically bent circular multilayer van der Waals (vdW) material sheets, which correspond to the nonisometric configuration in bulge tests. Frenkel sinusoidal function is employed to describe the periodic interlayer tractions due to the lattice structure nature and the bending stiffness of sheets is theoretically extracted via an energetic consideration. Our quantitative prediction shows good agreement with recent experimental results, where the bending stiffness of different types of sheets with the comparable thickness could follow a trend opposite to their Young’s moduli. On the basis of our model, we propose that this trend may experience a transition as the thickness decreases. Apart from the apparent effects of Young’s modulus and interlayer shear strength, the interlayer distance is also found to have an important impact on the bending stiffness. In addition, according to our analysis on the size effect, the bending stiffness of such symmetrically bent circular sheets can steadily own a relatively large value, in contrast to the cases of isometric deformations.
Antioxidant Supplementation Protects Elite Athlete Muscle Integrity During Submaximal Training
Authors: Gillam Ian H. , Cunningham Ross B. , Telford Richard D. 
Published: January 2022

Purpose: To determine (1) the effect of a 40-minute steady-state run on muscle membrane integrity of elite athletes as reflected by serum creatine kinase (CK), (2) whether antioxidant supplementation (AS) with vitamins E and C has a protective effect, and (3) if a minimal blood concentration of vitamin E or C is required for any such protection. Methods: Fifteen elite-level endurance athletes () were randomly assigned to 6 weeks AS (1000 IU·d−1 natural vitamin E and 1000 mg·d−1 vitamin C) or placebo. Using a double-blind crossover design and 4-week washout period, each treatment was followed by a 40-minute steady-state run at 3 mM blood lactate. Blood samples before and 0 and 24 hours after the run were assayed for serum and red cell α-tocopherol (α-TOH), serum ascorbate, and CK. Results: The AS produced a 2.5-fold, well-correlated (r = .84) increase in serum and red cell α-TOH (P < .001) that attenuated the increase in postrun CK (P = .01). There was no change in serum ascorbate with AS and no relationship with CK (P > .1). Curvilinear regression revealed some evidence that a critical level of serum α-TOH in the vicinity of 12 mg·L−1 was required to attenuate CK efflux, a level only achieved with AS. Conclusion: The muscle membrane integrity of elite-level athletes is compromised even during steady-state running of moderate intensity and duration. The AS provided a protective effect, with evidence that a serum α-TOH concentration of around 12 mg·L−1 is required.
There Is No Global Running Pattern More Economic Than Another at Endurance Running Speeds
Authors: Patoz Aurélien , Lussiana Thibault , Breine Bastiaan , Gindre Cyrille , Hébert-Losier Kim 
Published: January 2022

Purpose: The subjective Volodalen® score (V®score) and the objective duty factor metric can both assess global running patterns. The authors aimed to investigate the relation between running economy (RE) at endurance running speeds and the global running pattern quantified using both subjective and objective measures. Methods: RE and 3-dimensional whole-body kinematics were acquired by indirect calorimetry and an optoelectronic system, respectively, for 52 trained runners during treadmill runs at 10, 12, and 14 km/h. Results: Correlations between RE and V®score and RE and duty factor were negligible and nonsignificant across speeds tested (P ≥ .20), except for a low and significant correlation between RE and V®score at 10 km/h. Conclusions: These findings suggest there is no global running pattern more economic than another at endurance running speeds. Therefore, there is no advantage of choosing, favoring, or prescribing one specific global running pattern along a continuum based on V®score or duty factor metrics, and coaches should not try to modify the spontaneous running pattern of runners at endurance running speed to improve RE.
Conceptualising fairness: three pillars for medical algorithms and health equity
Authors: Sikstrom Laura , Maslej Marta M , Hui Katrina , Findlay Zoe , Buchman Daniel Z , Hill Sean L 
Published: January 2022

ObjectivesFairness is a core concept meant to grapple with different forms of discrimination and bias that emerge with advances in Artificial Intelligence (eg, machine learning, ML). Yet, claims to fairness in ML discourses are often vague and contradictory. The response to these issues within the scientific community has been technocratic. Studies either measure (mathematically) competing definitions of fairness, and/or recommend a range of governance tools (eg, fairness checklists or guiding principles). To advance efforts to operationalise fairness in medicine, we synthesised a broad range of literature.MethodsWe conducted an environmental scan of English language literature on fairness from 1960-July 31, 2021. Electronic databases Medline, PubMed and Google Scholar were searched, supplemented by additional hand searches. Data from 213 selected publications were analysed using rapid framework analysis. Search and analysis were completed in two rounds: to explore previously identified issues (a priori), as well as those emerging from the analysis (de novo).ResultsOur synthesis identified ‘Three Pillars for Fairness’: transparency, impartiality and inclusion. We draw on these insights to propose a multidimensional conceptual framework to guide empirical research on the operationalisation of fairness in healthcare.DiscussionWe apply the conceptual framework generated by our synthesis to risk assessment in psychiatry as a case study. We argue that any claim to fairness must reflect critical assessment and ongoing social and political deliberation around these three pillars with a range of stakeholders, including patients.ConclusionWe conclude by outlining areas for further research that would bolster ongoing commitments to fairness and health equity in healthcare.
Efficacy of topical cannabinoids in the management of pain: a systematic review and meta-analysis of animal studies
Authors: Linde Lukas D , Ogryzlo Carey M , Choles Cassandra M , Cairns Brian E , Kramer John L K 
Published: January 2022

Background/importanceCannabinoids are emerging as an alternative pain management option, preliminarily supported by preclinical and clinical studies. Unwanted side effects from oral or inhaled cannabinoids remain, however, a major barrier to widespread use. Peripherally acting cannabinoids (eg, topically applied) may circumvent these side effects while providing localized pain management.ObjectiveOur purpose was to systematically review the literature on the effectiveness of peripherally acting cannabinoids for pain management.Evidence reviewWe searched MEDLINE, EMBASE, CENTRAL, CINAHL, and PubMed databases. Included studies examined the effect of topical/peripherally administered cannabinoids on pain ratings in humans, as well as pain-related outcomes in animals (eg, paw withdrawal). Due to a lack of trials, human studies were summarized in a narrative synthesis. Separate meta-analyses were performed for animal studies using radiant tail flick or paw withdrawal outcomes.FindingsOur search yielded 1182 studies following removal of duplicates, with 46 studies (6 human, 40 animal) included. Human studies (one randomized controlled trial and five case studies/series) reported no adverse events to topical cannabinoids and preliminary evidence of decreased pain ratings. Animal studies reporting tail flick (5) (2.81, 95% CI 1.93 to 3.69, p<0.001) and mechanical withdrawal (11) (2.74, 95% CI 1.82 to 3.67, p<0.001) reported prolonged responses (analgesia) in peripheral cannabinoid groups compared with controls.ConclusionsPreclinical animal studies provided low-quality evidence for peripherally administered cannabinoids to provide regional, antinociceptive effects. The scarcity of high-quality human studies underscores the need to translate preclinical evidence into well-controlled human trials.
Depth of cervical plexus block and phrenic nerve blockade: a randomized trial
Authors: Opperer Mathias , Kaufmann Reinhard , Meissnitzer Matthias , Enzmann Florian K , Dinges Christian , Hitzl Wolfgang , Nawratil Jürgen , Koköfer Andreas 
Published: January 2022

Background and objectivesCervical plexus blocks are commonly used to facilitate carotid endarterectomy (CEA) in the awake patient. These blocks can be divided into superficial, intermediate, and deep blocks by their relation to the fasciae of the neck. We hypothesized that the depth of block would have a significant impact on phrenic nerve blockade and consequently hemi-diaphragmatic motion.MethodsWe enrolled 45 patients in an observer blinded randomized controlled trial, scheduled for elective, awake CEA. Patients received either deep, intermediate, or superficial cervical plexus blocks, using 20 mL of 0.5% ropivacaine mixed with an MRI contrast agent. Before and after placement of the block, transabdominal ultrasound measurements of diaphragmatic movement were performed. Patients underwent MRI of the neck to evaluate spread of the injectate, as well as lung function measurements. The primary outcome was ipsilateral difference of hemi-diaphragmatic motion during forced inspiration between study groups.ResultsPostoperatively, forced inspiration movement of the ipsilateral diaphragm (4.34±1.06, 3.86±1.24, 2.04±1.20 (mean in cm±SD for superficial, intermediate and deep, respectively)) was statistically different between block groups (p<0.001). Differences were also seen during normal inspiration. Lung function, oxygen saturation, complication rates, and patient satisfaction did not differ. MRI studies indicated pronounced permeation across the superficial fascia, but nevertheless easily distinguishable spread of injectate within the targeted compartments.ConclusionsWe studied the characteristics and side effects of cervical plexus blocks by depth of injection. Diaphragmatic dysfunction was most pronounced in the deep cervical plexus block group.Trial registration numberEudraCT 2017-001300-30.
Standard Model in Weyl conformal geometry
Authors: Ghilencea D. M. 
Published: January 2022

AbstractWe study the Standard Model (SM) in Weyl conformal geometry. This embedding is truly minimal with no new fields beyond the SM spectrum and Weyl geometry. The action inherits a gauged scale symmetry D(1) (known as Weyl gauge symmetry) from the underlying geometry. The associated Weyl quadratic gravity undergoes spontaneous breaking of D(1) by a geometric Stueckelberg mechanism in which the Weyl gauge field ($$\omega _\mu $$

ω
μ

) acquires mass by “absorbing” the spin-zero mode of the $${\tilde{R}}^2$$

R
~

2

term in the action. This mode also generates the Planck scale and the cosmological constant. The Einstein-Proca action emerges in the broken phase. In the presence of the SM, this mechanism receives corrections (from the Higgs) and it can induce electroweak (EW) symmetry breaking. The EW scale is proportional to the vev of the Stueckelberg field. The Higgs field ($$\sigma $$
σ
) has direct couplings to the Weyl gauge field ($$\sigma ^2\omega _\mu \omega ^\mu $$

σ
2

ω
μ

ω
μ

). The SM fermions only acquire such couplings for non-vanishing kinetic mixing of the gauge fields of $$D(1)\times U(1)_Y$$

D

(
1
)

×
U

(
1
)

Y

. If this mixing is present, part of the mass of Z boson is not due to the usual Higgs mechanism, but to its mixing with massive $$\omega _\mu $$

ω
μ

. Precision measurements of Z mass then set lower bounds on the mass of $$\omega _\mu $$

ω
μ

which can be light (few TeV). In the early Universe the Higgs field can have a geometric origin, by Weyl vector fusion, and the Higgs potential can drive inflation. The dependence of the tensor-to-scalar ratio r on the spectral index $$n_s$$

n
s

is similar to that in Starobinsky inflation but mildly shifted to lower r by the Higgs non-minimal coupling to Weyl geometry.
Health-Related Quality of Life Outcomes in Patients with Resected Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung Cancer Who Received Adjuvant Osimertinib in the Phase III ADAURA Trial
Authors: Majem Margarita , Goldman Jonathan W. , John Thomas , Grohe Christian , Laktionov Konstantin , Kim Sang-We , Kato Terufumi , Vu Huu Vinh , Lu Shun , Li Shanqing , Lee Kye Young , Akewanlop Charuwan , Yu Chong-Jen , de Marinis Filippo , Bonanno Laura , Domine Manuel , Shepherd Frances A. , Atagi Shinji , Zeng Lingmin , Kulkarni Dakshayini , Medic Nenad , Tsuboi Masahiro , Herbst Roy S. , Wu Yi-Long 
Published: January 2022

Abstract

Purpose:
In the phase III ADAURA trial, adjuvant treatment with osimertinib versus placebo, with/without prior adjuvant chemotherapy, resulted in a statistically significant and clinically meaningful disease-free survival benefit in completely resected stage IB–IIIA EGFR-mutated (EGFRm) non–small cell lung cancer (NSCLC). We report health-related quality of life (HRQoL) outcomes from ADAURA.

Patients and Methods:
Patients randomized 1:1 received oral osimertinib 80 mg or placebo for 3 years or until recurrence/discontinuation. HRQoL (secondary endpoint) was measured using the Short Form-36 (SF-36) health survey at baseline, 12, and 24 weeks, then every 24 weeks until recurrence or treatment completion/discontinuation. Exploratory analyses of SF-36 score changes from baseline until week 96 and time to deterioration (TTD) were performed in the overall population (stage IB–IIIA; N = 682). Clinically meaningful changes were defined using the SF-36 manual.

Results:
Baseline physical/mental component summary (PCS/MCS) scores were comparable between osimertinib and placebo (range, 46–47) and maintained to Week 96, with no clinically meaningful differences between arms; difference in adjusted least squares (LS) mean [95% confidence intervals (CI), −1.18 (−2.02 to −0.34) and −1.34 (−2.40 to −0.28), for PCS and MCS, respectively. There were no differences between arms for TTD of PCS and MCS; HR, 1.17 (95% CI, 0.82–1.67) and HR, 0.98 (95% CI, 0.70–1.39), respectively.

Conclusions:
HRQoL was maintained with adjuvant osimertinib in patients with stage IB–IIIA EGFRm NSCLC, who were disease-free after complete resection, with no clinically meaningful differences versus placebo, further supporting adjuvant osimertinib as a new treatment in this setting.
See related commentary by Patil and Bunn, p. 2204