bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Right Ventricular Dilation and Dysfunction on Echocardiogram with In-Hospital Mortality Among Patients Hospitalized with COVID-19 Compared with Other Acute Respiratory Illness
Authors: Sun Kaiwen , Cedarbaum Emily , Hill Christopher , Win Sithu , Parikh Nisha I. , Hsue Priscilla Y. , Durstenfeld Matthew S. 
Published: June 2022

ABSTRACTBackgroundAlthough right ventricular (RV) dysfunction is associated with mortality in acute COVID-19, the role of RV dilation is uncertain. The prognostic significance of RV dilation and dysfunction among hospitalized patients with acute COVID-19 compared to other respiratory illnesses.MethodsWe conducted a retrospective cohort study to examine 225 consecutive adults admitted for acute COVID-19 and 6,150 control adults admitted for influenza, pneumonia or ARDS who had a clinical echocardiogram performed. We used logistic regression models to assess associations between RV parameters and in-hospital mortality adjusted for confounders.ResultsAmong those with COVID-19, 48/225 (21.3%) died during the index hospitalization compared to 727/6150 (11.8%) with other respiratory illness (p=0.001). Independent of COVID-19, mild and moderate to severe RV dilation were associated with 1.4 and 2.0 times higher risk of inpatient mortality, respectively (95%CI 1.17 to 1.69; p=0.0003; 95%CI 1.62 to 2.47; p<0.0001, respectively). Similarly, mild and moderate RV dysfunction were associated with 1.4 and 1.7 times higher risk of inpatient mortality (95%CI 1.10 to 1.77; p=0.007; 95%CI 1.17 to 2.42; p=0.005, respectively). Relative to normal RV size and non-COVID-19 acute respiratory illness, mild and moderate RV dilation were associated with 1.4 times and 2.0 times higher risk among those without COVID-19 and 1.9 times higher and 3.0 times higher risk among those with COVID-19, with similar findings for RV dysfunction. Having both RV dilation and dysfunction or RV dilation alone were associated with 1.7 times higher risk while RV dysfunction alone was associated with 1.4 times higher risk compared to normal RV size and function.ConclusionsRV dilation and dysfunction are associated with increased risk of inpatient mortality among those with COVID-19 and other respiratory illnesses. Abnormal RV findings may identify those at higher risk of short-term mortality from acute respiratory illness including COVID-19 beyond other risk markers.
Genetic transformation and cell division delay in competent Staphylococcus aureus
Authors: Morgene Fedy , Zeghlache Célia Rizoug , Feng Shi Yuan , Hauck Yolande , Mirouze Nicolas 
Published: June 2022

SummaryNatural competence for genetic transformation, considered as one of the three main mechanisms leading to horizontal gene transfer in bacteria, is able to promote evolution, through genomic plasticity, and foster antibiotic resistance and virulence factors spreading. Conserved machineries and actors required to perform genetic transformation have been shown to accumulate at different cellular localizations depending on the model organism considered.Here, we show in the human pathogen Staphylococcus aureus that DNA binding, uptake and recombination are spatially and temporally coordinated to ensure S. aureus genetic transformation. We also reveal that localization of genetic transformation proteins is dynamic and preferentially occurs in the vicinity of the division septum. We finally propose that S. aureus competent cells would initiate and then block cell division to ensure the success of genetic transformation before the final constriction of the cytokinetic ring.
Trim-Away degrades lysine-less substrates without requiring ligase autoubiquitination
Authors: Kiss Leo , Rhinesmith Tyler , Dickson Claire F , Weidenhausen Jonas , Smyly Shannon , Luptak Jakub , Yang Ji-Chun , Maslen Sarah L , Sinning Irmgard , Neuhaus David , Clift Dean , James Leo C 
Published: June 2022

ABSTRACTTRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away. Despite their importance, the ubiquitination mechanism of TRIM ligases has remained elusive. Here we show that while TRIM21 activation results in ubiquitination of both ligase and substrate, autoubiquitination is regulatory and not required for substrate degradation. Substrate binding stimulates N-terminal RING autoubiquitination by the E2 Ube2W, but when inhibited by N-terminal acetylation this prevents neither substrate ubiquitination nor degradation and has no impact on TRIM21 antiviral activity. Instead, uncoupling ligase and substrate degradation prevents ligase recycling and extends functional persistence in cells. Substrate ubiquitination mediates degradation but Trim-Away efficiently degrades lysine-less substrates, suggesting a non-canonical ubiquitination mechanism explains its broad substrate specificity.
Multi-stage resistance toZymoseptoria triticirevealed by GWAS in an Australian bread wheat (Triticum aestivumL.) diversity panel
Authors: Yang Nannan , Ovenden Ben , Baxter Brad , McDonald Megan C. , Solomon Peter S. , Milgate Andrew 
Published: June 2022

AbstractSeptoria tritici blotch (STB) has been ranked the third most important wheat disease in the world, threatening a large area of wheat production. Although major genes play an important role in the protection againstZymoseptoria triticiinfection, the lifespan of their resistance unfortunately is very short in modern agriculture systems. Combinations of quantitative resistance with minor effects, therefore, are believed to have prolonged and more durable resistance toZ. tritici. In this study new quantitative trait loci (QTLs) were identified that are responsible for seedling-stage resistance and adult-plant stage resistance (APR). More importantly was the characterisation of a previously unidentified QTL that can provide resistance during different stages of plant growth or multi-stage resistance (MSR). At the seedling stage, we discovered a new isolate-specific QTL, QSt.wai.1A.1. At the adult-plant stage, the new QTL QStb.wai.6A.2 provided stable and consistent APR in multiple sites and years, while the QTL QStb.wai.7A.2 was highlighted to have MSR. The stacking of multiple favourable MSR alleles was found to improve resistance toZ. triticiby up to 40%.Key messageAn Australian GWAS panel discovered three new QTLs associated with seedling-stage resistance, adult-plant stage resistance, and multi-stage resistance, respectively.
APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids
Authors: Zhao Jing , Ikezu Tadafumi C. , Lu Wenyan , Macyczko Jesse R. , Li Yonghe , Lewis-Tuffin Laura J. , Martens Yuka A. , Ren Yingxue , Zhu Yiyang , Asmann Yan W. , Ertekin-Taner Nilüfer , Kanekiyo Takahisa , Bu Guojun 
Published: June 2022

AbstractThe apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain transporting lipids such as cholesterol among different brain cell types. Here, we show that APOE deficiency in human iPSC-derived cerebral organoids impacts brain lipid homeostasis by modulating multiple cellular and molecular pathways. Molecular profiling through single cell RNA-sequencing revealed that APOE deficiency leads to changes in cellular composition of isogenic cerebral organoids likely by modulating the EIF2 signaling pathway as these events were alleviated by the treatment of a pathway inhibitor ISRIB. APOE deletion also leads to activation of the Wnt/β-catenin signaling pathway with concomitant decrease of SFRP1 expression in glia cells. Importantly, the critical role of apoE in cell type-specific lipid homeostasis was observed upon APOE deletion in cerebral organoids with a specific upregulation of cholesterol biosynthesis in excitatory neurons and excessive lipid accumulation in astrocytes. Relevant to human AD, APOE4 cerebral organoids show altered neurogenesis and cholesterol metabolism compared to those with APOE3. Our work demonstrates critical roles of apoE in brain homeostasis and offers critical insights into the APOE4-related pathogenic mechanisms.
Stock market reaction to affiliated sports teams’ performance: evidence from China
Authors: Gao Yongqiang , Wang Yingli , Hafsi Taïeb 
Published: June 2022

Purpose
Drawing on the affect transfer and stakeholder theories, this study aims to examine how the performance of a sports team that a firm owns or sponsors may affect the firm’s market value. It explicates that a sports team wins (loses) in the field raises the public’s positive (negative) affect, which can spill over to the associated firm.

Design/methodology/approach
Based on a sample of publicly listed firms in Chinese stock exchanges that are owners or sponsors of soccer teams that competed in the National soccer league of China during 2004–2017, the authors find good support for the hypotheses.

Findings
The findings reveal that a firm’s cumulative abnormal return is positively related to its soccer team’s winning and negatively related to the team’s losing, and these relationships are moderated by both firm and match characteristics. By showing a relationship between sports team’s performance and associated firm’s market value, executives need cautions when their firms want to own or sponsor sports team. However, owned sports team’s winning could be a good strategy to improve a firm’s market value.

Originality/value
This study enriches the spillover literature and deepens the understanding of spillover effect. It provides evidence for the concept of affect transfer and broadens its application scope.
What do they make us see: a comparative study of cultural bias in online databases of two large museums
Authors: Zhitomirsky-Geffet Maayan , Kizhner Inna , Minster Sara 
Published: June 2022

PurposeLarge cultural heritage datasets from museum collections tend to be biased and demonstrate omissions that result from a series of decisions at various stages of the collection construction. The purpose of this study is to apply a set of ethical criteria to compare the level of bias of six online databases produced by two major art museums, identifying the most biased and the least biased databases.Design/methodology/approachAt the first stage, the relevant data have been automatically extracted from all six databases and mapped to a unified ontological scheme based on Wikidata. Then, the authors applied ethical criteria to the results of the geographical distribution of records provided by two major art museums as online databases accessed via museums' websites, API datasets and datasets submitted to Wikidata.FindingsThe authors show that the museums use different artworks in each of its online databases and each data-base has different types of bias reflected by the study variables, such as artworks' country of origin or the creator's nationality. For most variables, the database behind the online search system on the museum's website is more balanced and ethical than the API dataset and Wikidata databases of the two museums.Originality/valueBy applying ethical criteria to the analysis of cultural bias in various museum databases aimed at different audiences including end users, researchers and commercial institutions, this paper shows the importance of explicating bias and maintaining integrity in cultural heritage representation through different channels that potentially have high impact on how culture is perceived, disseminated, contextualized and transformed.
Barriers to entry: an empirical account of business creation difficulties in the United States 2011
Authors: Teague Megan V. 
Published: June 2022

PurposeThis study acts as a proof of concept to address how general, broadly applicable barriers to starting a business impact entry across various firm sizes.Design/methodology/approachThe following investigation uses barriers to entry data in Teague (2016) to explore the costs of government intervention within the United States for 2011.FindingsResults from cross sectional regression analysis of business entry rates across nine different business size classifications on a composite barrier to entry variable yield two main findings: (1) increase in barriers to entry decrease business growth for most establishment sizes and (2) increase in barriers to entry for larger firms result in positive entry rates.Originality/valueThis study is the first exploration of general, broadly applicable barriers to entry measures and entry rates. Its preliminary findings suggest that barriers to entry encourage development of larger business sizes at the possible expense of smaller businesses. This result encourages further work into the interconnectedness of government and business.
Digital transformation maturity model development framework based on design science: case studies in manufacturing industry
Authors: Kırmızı Mehmet , Kocaoglu Batuhan 
Published: June 2022

PurposeThis study aims to propose a novel maturity model development framework based on design science theory utilizing qualitative and quantitative methods for empirical evidence and develops a descriptive digital transformation maturity model by using the proposed framework.Design/methodology/approachDesign science theory is deeply explored and extended to propose a novel maturity model development approach, including robust and rigorous validation processes. Thus, three consecutive discussion sessions and evaluations with experts are carried out iteratively to evolve and saturate the efficiency and utility of the maturity model, and consensus among experts at each session is validated by the intra-class correlation (ICC) coefficient. Furthermore, the Wilcoxon signed rank test is utilized to test whether there is a difference between consecutive sessions. Finally, prototype testing as a pilot study and two case studies in the manufacturing industry are carried out to validate the applicability of the developed maturity model.FindingsA 3-phase maturity model development framework that includes the activities and outcomes in each phase emerge based on the design science theory. The comparative literature analysis and discussion sessions resulted in six dimensions, ten sub-dimensions, 39-capability items that circumscribe the digital transformation concept and five maturity levels that demonstrate conceptual consistency and a measurement tool for self-assessment. In addition, prototype testing and case studies show that the developed maturity model can measure the company's maturity level. Finally, it is proven that the digital transformation maturity model is developed by following the proposed maturity model development framework.Practical implicationsThe maturity model draws a framework for practitioners that facilitate an initial roadmap and enhance the adoption rate, and it motivates the practitioners for frequent and efficient assessments, thus helping the continuous improvement of the digital transformation journey.Originality/valueThe originality of this paper lies in proposing a novel maturity model development framework based on design science and presents the activities and validation methods for this purpose. Furthermore, a comprehensive and rigorously validated digital transformation maturity model is developed based on the proposed framework.
Enhancing quality of teaching in the built environment higher education, UK
Authors: Gomis Kasun , Saini Mandeep , Pathirage Chaminda , Arif Mohammed 
Published: June 2022

Purpose
The issues in the current Built Environment Higher Education (BEHE) curricula recognise a critical need for enhancing the quality of teaching. This paper aims to identify the need for a best practice in teaching within BEHE curricula and recommend a set of drivers to enhance the current teaching practices in the Built Environment (BE) education. The study focused on Section 1 of the National Student Survey (NSS) – Teaching on my course, with a core focus on improving student satisfaction, making the subject interesting, creating an intellectually stimulating environment and challenging learners.

Design/methodology/approach
The research method used in this study is the mixed method, a document analysis consisting of feedback from undergraduate students and a closed-ended questionnaire to the academics in the BEHE context. More than 375 student feedback were analysed to understand the teaching practices in BE and fed forward to developing the closed-ended questionnaire for 23 academics, including a Head of School, a Principal Lecturer, Subject Leads and Lecturers. The data was collected from Architecture, Construction Management, Civil Engineering, Quantity Surveying and Building surveying disciplines representing BE context. The data obtained from both instruments were analysed with content analysis to develop 24 drivers to enhance the quality of teaching. These drivers were then modelled using the interpretive structural modelling (ISM) method to identify their correlation and criticality to NSS Section 1 themes.

Findings
The study revealed 10 independent, 11 dependent and three autonomous drivers, facilitating the best teaching practices in BEHE. The study further recommends that the drivers be implemented as illustrated in the level partitioning diagrams under each NSS Section 1 to enhance the quality of teaching in BEHE.

Practical implications
The recommended set of drivers and the level partitioning can be set as a guideline for academics and other academic institutions to enhance the quality of teaching. This could be further used to improve student satisfaction and overall NSS results to increase the rankings of academic institutions.

Originality/value
New knowledge can be recognised with the ISM analysis and level partitioning diagrams of the recommended drivers to assist academics and academic institutions in developing the quality of teaching.
Looking within: a longitudinal qualitative analysis of shared leadership behaviours in organisational teams
Authors: Sweeney Anne 
Published: June 2022

Purpose
To date, empirical research on shared leadership (SL) has been dominated by quantitative studies of antecedents and outcomes, frequently in simulated environments. Consequently, there have been few authentic accounts of how SL is practiced within organisational teams. Underpinned by shared leadership theory and leadership behaviour theory, this paper aims to provide a fine-grained view of the SL behaviours exhibited by team members over time, in five organisational teams in Ireland.

Design/methodology/approach
This longitudinal qualitative study uses critical incident technique, semi-structured interviews and participant diaries to explore SL behaviours emerging in five teams over time.

Findings
SL became widespread over time in each team, with almost all (96%) team members exhibiting SL behaviours. Ten different leadership behaviours were exhibited, indicating that SL permits a wide variety of leadership behaviours to be expressed. Some leadership functions were rarely or never fulfilled by team members (team composition, performance monitoring and resource allocation), suggesting that these leadership behaviours are not amenable to sharing.

Practical implications
This paper provides an insight into how SL could be used to increase the leadership capacity in team-based organisations.

Originality/value
This paper adds depth to the understanding of SL, revealing the specific behaviours underlying this approach, expanding our understanding of the micro-dynamics at play in SL processes.
Climate dictates microbial community composition and diversity in Australian biological soil crusts (biocrusts)
Authors: Chilton Angela M. , Nguyen Suong T. T. , Nelson Tiffanie M. , Pearson Leanne A. , Neilan Brett A. 
Published: June 2022

AbstractThe soil surface of drylands can typically be colonized by cyanobacteria and other microbes, forming biological soil crusts or ‘biocrusts’. Biocrusts provide critical benefits to ecosystems and are a common component of the largely arid and semi‐arid Australian continent. Yet, their distribution and the parameters that shape their microbial composition have not been investigated. We present here the first detailed description of Australia's biocrust microbiome assessed from 15 sites across the continent using 16S rRNA sequencing. The most abundant bacterial phyla from all sites were Cyanobacteria, Proteobacteria, Actinobacteria, Chloroflexi and Bacteroidetes. Cyanobacterial communities from northern regions were more diverse and unclassified cyanobacteria were a noticeable feature of northern biocrusts. Segregation between northern and southern regions was largely due to the differential abundance of Microcoleus spp., with M. paludosus dominating in the north and M. vaginatus dominating in the south. The geographical shifts in bacterial composition and diversity were correlated to seasonal temperatures and summer rainfall. Our findings provide an initial reference for sampling strategies to maximize access to bacterial genetic diversity. As hubs for essential ecosystem services, further investigation into biocrusts in arid and semi‐arid regions may yield discoveries of genetic mechanisms that combat increases in warming due to climate change.
Late Pleistocene‐dated divergence between South Hemisphere populations of the non‐conventional yeast L. cidri
Authors: Villarreal Pablo , Villarroel Carlos A. , O'Donnell Sam , Agier Nicolas , Quintero‐Galvis Julian F. , Peña Tomas A. , Nespolo Roberto F. , Fischer Gilles , Varela Cristian , Cubillos Francisco A. 
Published: June 2022

AbstractMost organisms belonging to the Saccharomycotina subphylum have high genetic diversity and a vast repertoire of metabolisms and lifestyles. Lachancea cidri is an ideal yeast model for exploring the interplay between genetics, ecological function and evolution. Lachancea cidri diverged from the Saccharomyces lineage before the whole‐genome duplication and is distributed across the South Hemisphere, displaying an important ecological success. We applied phylogenomics to investigate the genetic variation of L. cidri isolates obtained from Australia and South America. Our approach revealed the presence of two main lineages according to their geographic distribution (Aus and SoAm). Estimation of the divergence time suggests that SoAm and Aus lineages diverged near the last glacial maximum event during the Pleistocene (64‐8 KYA). Interestingly, we found that the French reference strain is closely related to the Australian strains, with a recent divergence (405‐51 YA), likely associated to human movements. Additionally, we identified different lineages within the South American population, revealing that Patagonia contains a similar genetic diversity comparable to that of other lineages in S. cerevisiae. These findings support the idea of a Pleistocene‐dated divergence between South Hemisphere lineages, where the Nothofagus and Araucaria ecological niches likely favoured the extensive distribution of L. cidri in Patagonia.