bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing Technology Literacy Programs in Retirement Homes and Residential Care Facilities: Conceptual Framework
Authors: Li Karen S , Nagallo Nathan , McDonald Erica , Whaley Colin , Grindrod Kelly , Boluk Karla 
Published: June 2022

Background
The COVID-19 pandemic caused widespread societal disruption, with governmental stay-at-home orders resulting in people connecting more via technology rather than in person. This shift had major impacts on older adult residents staying in retirement homes and residential care facilities, where they may lack the technology literacy needed to stay connected. The enTECH Computer Club from the University of Waterloo in Ontario, Canada created a knowledge translation toolkit to support organizations interested in starting technology literacy programs (TLPs) by providing guidance and practical tips.

Objective
This paper aimed to present a framework for implementing TLPs in retirement homes and residential care facilities through expanding on the knowledge translation toolkit and the framework for person-centered care.

Methods
Major concepts relating to the creation of a TLP in retirement homes and residential care facilities were extracted from the enTECH knowledge translation toolkit. The domains from the framework for person-centered care were modified to fit a TLP context. The concepts identified from the toolkit were sorted into the three framework categories: “structure,” “process,” and “outcome.” Information from the knowledge translation toolkit were extracted into the three categories and synthesized to form foundational principles and potential actions.

Results
All 13 domains from the framework for person-centered care were redefined to shift the focus on TLP implementation, with 7 domains under “structure,” 4 domains under “process,” and 2 domains under “outcome.” Domains in the “structure” category focus on developing an organizational infrastructure to deliver a successful TLP; 10 foundational principles and 25 potential actions were identified for this category. Domains in the “process” category focus on outlining procedures taken by stakeholders involved to ensure a smooth transition from conceptualization into action; 12 foundational principles and 9 potential actions were identified for this category. Domains in the “outcome” category focus on evaluating the TLP to consider making any improvements to better serve the needs of older adults and staff; 6 foundational principles and 6 potential actions were identified for this category.

Conclusions
Several domains and their foundational principles and potential actions from the TLP framework were found to be consistent with existing literatures that encourage taking active steps to increase technology literacy in older adults. Although there may be some limitations to the components of the framework with the current state of the pandemic, starting TLPs in the community can yield positive outcomes that will be beneficial to both older adult participants and the organization in the long term.
Antimicrobial Use in Pediatric Oncology and Hematology: Protocol for a Multicenter Point-Prevalence Study With Qualitative Expert Panel Assessment
Authors: Papan Cihan , Reifenrath Katharina , Last Katharina , Attarbaschi Andishe , Graf Norbert , Groll Andreas H , Huebner Johannes , Laws Hans-Jürgen , Lehrnbecher Thomas , Liese Johannes , Martin Luise , Tenenbaum Tobias , Weichert Stefan , Vieth Simon , von Both Ulrich , Hufnagel Markus , Simon Arne 
Published: June 2022

Background
Because infections are a major driver of morbidity and mortality in children with hematologic or oncologic diseases, antimicrobials are frequently prescribed in pediatric oncology practice. However, excess or inappropriate use of antimicrobials is directly linked to the emergence of antimicrobial resistance. Although point-prevalence studies have examined the extent of antimicrobial use, a comprehensive qualitative evaluation of individual antimicrobial prescriptions remains lacking.

Objective
The aim of this study is to identify appropriate versus inappropriate antimicrobial use among pediatric cancer patients in a point-prevalence study, followed by an expert panel adjudication process and a subsequent report of these findings to participating centers. This study also aims to improve the quality of patient care by informing centers about discrepancies between internal standards of care and national guidelines.

Methods
Our point-prevalence study is performed at pediatric cancer centers in Germany and Austria. All patients under 18 years old who are hospitalized at the time of the study are included. As a supplement to the point-prevalence study, an expert panel is qualitatively assessing each of the antimicrobial prescriptions at the participating centers to review local guidelines and compare them with national guidelines.

Results
As of December 2021, the point-prevalence survey has been conducted at 30 sites and expert panel adjudication for qualitative assessment of each antimicrobial use is ongoing. Results of the study are expected in 2022.

Conclusions
This is the first point-prevalence study conducted among pediatric cancer centers with an integrated, multistep, qualitative approach that assesses each antimicrobial prescription. The results of this study will inform possible interventions for internal guidelines and antimicrobial stewardship programs implemented at pediatric cancer centers. In addition, local guidelines will be compared with national guidelines. Furthermore, this study will contribute to the overall integration of antimicrobial stewardship principles and initiatives in pediatric oncology and hematology, thereby improving safety and quality of care for children and adolescents with cancer and blood disorders.

International Registered Report Identifier (IRRID)
DERR1-10.2196/35774
Integrasi Program Berkelanjutan Dalam Penanganan Kawasan Permukiman Kumuh di Kecamatan Tungkal Ilir
Authors: Muhammad Munzil Nur , Napitulu Dompak , Rosyani Rosyani 
Published: June 2022

The area of ​​the slum area in Tungkal Ilir District, Tanjung Jabung Barat Regency is 225.4 ha. The condition of buildings, environmental roads, environmental drainage, clean water, sanitation, solid waste and fire protection, are indicators of slum levels. In accordance with these indicators, the relevant Regional Apparatus Organizations (OPD) carry out programs in efforts to deal with slums. The purpose of this study is to analyze the effect of slum settlement management programs on the sustainability of slum area handling programs. The sampling method used is purposive sampling with 100 community respondents in slum locations and Stratified sampling with 30 ASN respondents, this study uses questionnaires and interviews with related parties in data retrieval. Analysis test uses SEM (Structural Equation Modeling) method and data processing using SmartPLS (Partial Least Square) software. The results showed the t-statistic for the Integration Program variable towards the Sustainable Cities variable was 2.185> t-statistic (1.96). The original sample estimate value shows a positive value (0.199). which shows that the relationship pattern of the integration of the program handling slum areas with the sustainability of the program is positive, with a moderate level. The results show that the integration of the program indirectly affects sustainable cities through community participation and slum areas that have not been implemented optimally and tend to be in the middle so that programs and activities that are integrated and synergized by the Regional Government in implementing sustainable cities still need to be implemented.
Keywords: Integration, Sustainable, Handling, Slums.
Analisis sistem pengelolaan limbah medis padat Puskesmas di Kabupaten Tanjung Jabung Barat ( Studi kasus di Puskesmas Rawat Inap Purwodadi Kec. Tebing Tinggi, Kab. Tanjung Jabung Barat )
Authors: Yanto Edisar , Syarifuddin Hutwan , Muhaimin Muhaimin 
Published: June 2022

ABSTRAK
Operasional Puskesmas akan menimbulkan limbah, yang berpotensi menimbulkan dampak terhadap masyarakat dan lingkungan hidup. Tujuan penelitian untuk menyusun strategi pengelolaan limbah medis padat di Puskesmas Rawat Inap Purwodadi. Metode penelitian kualitatif dengan pendekatan deskriptif, pelaksanaan penelitian bulan Oktober-November 2019. Populasi dalam penelitian ini semua pegawai yang bekerja di Puskesmas Rawat Inap Purwodadi. Teknik pengambilan informan menggunakan tekhnik Purposive sampling. Hasil penelitian, evaluasi faktor internal diperoleh selisih kekuatan dan kelemahan adalah -45, sedangkan selisih faktor eksternal peluang dan ancaman adalah +44, posisi penilaian faktor internal dan ekternal berada pada kuadran III (Negatif, positif). Dengan posisi ini strategi yang mendukung adalah turn around, artinya strategi pengelolaan limbah Puskesmas dapat disusun dengan memanfaatkan lokasi Puskesmas yang luas, tersedianya dana dan peraturan untuk memenimalkan kelemahan yang ada . Kesimpulan strategi yang mendukung pengelolaan limbah medis padat di Puskesmas dapat dilakukan dengan menjadikan PP No. 101 Tahun 2014 dan Permen LHK No. P.56 Tahun 2015 sebagai dasar pengelolaan limbah medis padat di Puskesmas, Peningkatan kapasitas SDM , peningkatan dukungan alokasi anggaran, Peningkatan Pengawasan kepatuhan petugas dalam menggunakan APD, dan usulan Pengadaan fasilitas pengelolaan limbah serta pemantapan kerja sama dengan pihak ketiga.
Kata kunci : sistem pengelolaan limbah, limbah medis padat puskesmas dan analisis SWOT
ANALISIS KEBERLANJUTAN USAHATANI SAYURAN KANGKUNG DI KECAMATAN PAAL MERAH KOTA JAMBI
Authors: Puja Winata Dwi , Suandi Suandi , Tatik Maryani Anis 
Published: June 2022

This study aims to describe farming activities kale in District Paal Merah city of Jambi, knowing sustainability index farm kale from the dimensions of the ecological, economic and social, as well as to determine the factors that affect adoption of sustainable farming kale in District Paal Merah city of Jambi. Methods of data analysis using descriptive analysis and quantitative analysis using MDS (Multi Dimension Scale) doped with Rapfish application. In addition, to determine the factors that affect the linear regression.
The result showed that: (1) The results of the analysis of vegetable farming income in the study area showed that vegetable farming that farmers provide benefits for farmers. The average farmer's income earned in the District of Paal Red kale Rp. 1.231.125,67;-, with the cost of Rp. Rp. 910.728,50;- and the reception received by farmers Rp 2.141.854,17;-. (2) The results of the analysis of the value of sustainable farming in the district kale Red Paal at 61.42. The figure shows the level of integration of sustainability kale farm in the District of Red Paal quite sustainability. With the analysis of the ecological dimensions of sustainability index of 71.27%, 57.10% of the economic dimension and the social dimension of 55.88%. (3) Based on the results of t-test analysis showed that, the value of sustainable farming in the district kale Red Paal farmers are affected by age. When viewed from the significance value then age watercress farmers have significant influence with age farmers. While the experience factor, farmers' income and education did not significantly affect the farmers to adopt sustainable farming values kale.
Keywords: farming kale, sustainability index, factors that affecting
Clinical significance and pitfalls of human chorionic gonadotropin related tumor markers for intracranial germinomas
Authors: Suzuki Tomonari , Shirahata Mitsuaki , Adachi Jun-ichi , Mishima Kazuhiko , Nishikawa Ryo 
Published: June 2022

Objective Measuring serum and cerebrospinal fluid human
chorionic gonadotropin (hCG) is essential for the diagnosis of
intracranial germ cell tumors. There are three types of hCG-related
markers in clinical use: hCGβ, intact hCG, and total hCG. The best
marker for the diagnosis of intracranial germ cell tumors, especially
germinoma, is currently unknown. This study aimed to evaluate the
usefulness of these hCG-related markers. Materials and Methods
We report six patients with histologically diagnosed germinoma treated
at our institute. Serum hCGβ, intact hCG, and total hCG were measured
before, during, and after treatment. Results The positivity
rates of serum hCGβ, intact hCG, and total hCG were 6% (1/17), 47%
(7/15), and 42% (8/19), respectively, with the latter two having
significantly higher positivity rates than hCGβ (p = 0.041). Both intact
and total hCGs showed similar values. The median value of hCGβ, intact
hCG, and total hCG before treatment was 0.1 ng/mL, 4.6 mIU/mL, and
4.5 mIU/mL, respectively. Conclusion Serum intact and total
hCGs have higher detection rates than hCGβ for patients with germinoma
using available commercial measurement tools.
Fasting Substrate Concentrations Predict Cardiovascular Outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS)
Authors: Ferrannini Ele , Baldi Simona , Scozzaro Tiziana , Tsimihodimos Vasilis , Tesfaye Fisseha , Shaw Wayne , Rosenthal Norman , Figtree Gemma A. , Neal Bruce , Mahaffey Kenneth W. , Perkovic Vlado , Hansen Michael K. 
Published: June 2022

OBJECTIVE
To examine whether the circulating substrate mix may be related to the incidence of heart failure (HF) and cardiovascular (CV) mortality and how it is altered by canagliflozin treatment.

RESEARCH DESIGN AND METHODS
We measured fasting glucose, free fatty acids (FFA), glycerol, β-hydroxybutyrate, acetoacetate, lactate, and pyruvate concentrations in 3,581 samples from the CANagliflozin cardioVascular Assessment Study (CANVAS) trial at baseline and at 1 and 2 years after randomization. Results were analyzed by univariate and multivariate Cox proportional hazards models.

RESULTS
Patients in the lowest baseline FFA tertile were more often men with a longer duration of type 2 diabetes (T2D), higher urinary albumin excretion, lower HDL-cholesterol levels, higher history of CV disease (CVD), and higher use of statins and insulin. When all seven metabolites were used as predictors, FFA were inversely associated with incident hospitalized HF (hazard ratio [HR] 0.33 [95% CI 0.21–0.55]), while glycerol was a positive predictor (2.21 [1.45–3.35]). In a model further adjusted for 16 potential confounders, including prior HF and CVD and pharmacologic therapies, FFA remained a significant negative predictor. FFA and glycerol also predicted CV mortality (HR 0.53 [95% CI 0.35–0.81] and 1.81 [1.26–2.58], respectively) and all-cause death (0.50 [0.36–0.70] and 1.64 [1.22–2.18]). When added to these models, background insulin therapy was an independent positive predictor of risk of death. Canagliflozin treatment significantly increased plasma FFA and β-hydroxybutyrate regardless of background antihyperglycemic therapy.

CONCLUSIONS
A constitutive metabolic setup consisting of higher lipolysis may be beneficial in delaying or preventing hospitalized HF; a further stimulation of lipolysis by canagliflozin may reinforce this influence.
Changes in Glucose Metabolism and Glycemic Status with Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants with Prediabetes in the STEP Program
Authors: Perreault Leigh , Davies Melanie , Frias Juan P. , Laursen Peter Nørkjaer , Lingvay Ildiko , Machineni Sriram , Varbo Anette , Wilding John P.H. , Wallenstein Signe Olrik Rytter , Roux Carel W. le 
Published: June 2022

<p><strong>Objective</strong></p>
<p>This analysis of 3,375 adults with overweight/obesity across the STEP 1, 3, and 4 trials evaluated whether more participants with prediabetes had normoglycemia after 68 weeks’ treatment with once-weekly semaglutide 2.4 mg plus lifestyle intervention versus placebo, and assessed changes in glucose metabolism in participants with prediabetes. </p>
<p><strong>Research Design and Methods</strong></p>
<p>STEP 1, 3, and 4 were phase 3, 68-week, randomized, placebo-controlled, multinational trials; STEP 4 had a 20-week semaglutide run-in and 48-week randomized period. Analyses included changes (week 0–68; before the washout period) in glycemic status (prespecified: STEP 1 and 3; post-hoc: STEP 4), and in HbA1c, fasting plasma glucose (FPG), and insulin resistance (HOMA-IR) among participants with prediabetes (post-hoc).</p>
<p><strong>Results</strong></p>
<p>Significantly more participants with baseline (week 0) prediabetes (n=1,536) had normoglycemia at week 68 with semaglutide versus placebo (STEP 1, 84.1% vs. 47.8%; STEP 3, 89.5% vs. 55.0%; STEP 4, 89.8% vs. 70.4%; all <em>P</em> < 0.0001). Fewer participants with baseline normoglycemia had prediabetes at week 68 with semaglutide versus placebo (STEP 1, 2.9% vs. 10.9%; STEP 3, 3.2% vs. 5.8%; STEP 4, 1.1% vs. 5.0%). Semaglutide resulted in greater improvements in HbA1c, FPG, and HOMA-IR than placebo among participants with baseline prediabetes (all <em>P</em> < 0.01).</p>
<p><strong>Conclusions</strong></p>
<p>STEP 1, 3, and 4 collectively provide a robust assessment of the effects of semaglutide on glucose metabolism and prediabetes in a large cohort of adults with overweight/obesity while on treatment. Among participants with baseline prediabetes, 68 weeks’ treatment with semaglutide vs. placebo led to significant improvements in glucose metabolism and a higher likelihood of normoglycemia.</p>
Fasting substrate concentrations predict cardiovascular outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS)
Authors: Ferrannini Ele , Baldi Simona , Scozzaro Tiziana , Tsimihodimos Vasilis , Tesfaye Fisseha , Shaw Wayne , Rosenthal Norman , Figtree Gemma A. , Neal Bruce , Mahaffey Kenneth W. , Perkovic Vlado , Hansen Michael K. 
Published: June 2022

<p> </p>
<p><strong>Objective</strong> To examine whether the circulating substrate mix may be related to the incidence of heart failure (HF) and cardiovascular (CV) mortality and how it is altered by canagliflozin treatment.</p>
<p><strong>Research Design and Methods </strong> We measured fasting glucose, free fatty acids (FFA), glycerol, β-hydroxybutyrate, acetoacetate, lactate, and pyruvate concentrations in 3,581 samples from the CANVAS trial at baseline and at 1 and 2 years after randomization. Results were analyzed by univariate and multivariate Cox proportional hazards models. </p>
<p><strong>Results</strong> Patients in the lowest baseline FFA tertile were more often men with a longer duration of T2D, higher urinary albumin excretion and lower HDL-cholesterol levels, higher history of CVD, and higher use of statins and insulin. Using all 7 metabolites as predictors, FFA were inversely associated with incident hospitalized HHF (0.33 [0.21–0.55]), while glycerol was a positive predictor (2.21 [1.45–3.35]). In a model further adjusted for 16 potential confounders (including prior HF and CV disease and pharmacologic therapies), FFA remained a significant negative predictor. FFA and glycerol also predicted CV mortality (0.53 [0.35–0.81] and 1.81 [1.26–2.58], respectively) and all-cause death (0.50 [0.36–0.70] and 1.64 [1.22–2.18]). When added to these models, background insulin therapy was an independent positive predictor of risk of death. Canagliflozin treatment significantly increased plasma FFA and β-hydroxybutyrate regardless of background antihyperglycemic therapy. </p>
<p><strong>Conclusions</strong> A constitutive metabolic setup consisting of higher lipolysis may be beneficial in delaying or preventing HHF; a further stimulation of lipolysis by canagliflozin may reinforce this influence. </p>
Caloric restriction and weight loss are primary factors in the early tissue-specific metabolic changes after bariatric surgery
Authors: Flynn Charles Robb , Tamboli Robyn A. , Antoun Joseph , Sidani Reem M. , Williams Brandon , Spann Matthew D. , English Wayne J. , Welch E. Brian , Sundaresan Sinju , Abumrad Naji N. 
Published: June 2022

<p> </p>
<p><strong>OBJECTIVE</strong></p>
<p>To evaluate changes in insulin sensitivity, hormone secretion, and hepatic steatosis immediately after caloric restriction, vertical sleeve gastrectomy (VSG), and Roux-en-Y gastric bypass (RYGB).</p>
<p><strong>RESEARCH DESIGN AND METHODS</strong></p>
<p>Obese subjects were assessed for: <em>1</em>) insulin sensitivity by hyperinsulinemic-euglycemic clamp with glucose tracer infusion, <em>2</em>) adipokine concentrations by sampling serum and subcutaneous adipose interstitial fluid, and <em>3</em>) hepatic fat content by magnetic resonance imaging before and 7-10 days after VSG, RYGB, or supervised caloric restriction.</p>
<p><strong>RESULTS</strong></p>
<p>Each group exhibited an approximately 5% total body weight loss, accompanied by similar improvements in hepatic glucose production and hepatic, skeletal muscle, and adipose tissue insulin sensitivity. Leptin concentrations in plasma and adipose interstitial fluid were equally decreased and reductions in hepatic fat were similar.</p>
<p><strong>CONCLUSIONS</strong></p>
<p>The improvements in insulin sensitivity and adipokine secretion observed early after bariatric surgery are replicated by equivalent caloric restriction and weight loss. </p>
Karakteristik BUMDes Pesisir pada Kawasan Pertambangan Emas di Kecamatan Maluk Sumbawa Barat
Authors: Ibrahim Ibrahim , Setiadi Setiadi , Saleh Muhammad , Gani Arsyad Abdul , Mintasrihardi Mintasrihardi , Am Junaidi , Mas'ad Mas'ad , Kamaluddin Kamaluddin 
Published: June 2022

Keberadaan Badan Usaha Milik Desa (BUMDes) sebagai aset ekonomi berada di desa dengan Pengelolaan sepenuhnya oleh masyarakat belum memiliki pemanfaatan dalam mendukung ekonomi masyarakat. Tujuan penelitian ini adalah untuk menganalisis karakteristik badan usaha milik desa pesisir pada kawasan pertambangan emas di Kecamatan Maluk Sumbawa Barat.Penelitian ini menggunakan penelitian kuantitatif dengan metode survei yang mengambil sampel dari sejumlah populasi dan menggunakan kuesioner sebagai alat mengumpulkan data utama. Populasi dalam penelitian ini sebanyak 1701 rumah tangga. penentuan sampel responden menggunakan tehnik proportional random sampling. Penentuan sampel responden rumah tangga menggunakan sampel sebesar 5 persen. Persebaran responden pada lokasi penelitian berdasarkan jumlah populasi (rumah tangga). Jumlah sampel responden pada masing-masing lokasi penelitian sebanyak 89 responden. Analisis yang digunakan untuk menguji tujuan tersebut menggunakan analsis frekuensi dan tabulasi silang. Hasilpenelitian ini menunjukan bahwa karakteristik BUMDes pesisir pada kawasan pertambangan emas di Kabupaten Sumbawa Barat berdasarkan organisasi dalam kategori tertinggi pada level rendah mencapai 61,8 persen, program BUMDes pada kategori tertinggi pada level terendah mencapai 61,79 persen dan sumberdaya pengelola pada ketegori tertinggi pada level terendah mencapai 61,79 persen. Keberadaan BUMDes ditengah masyarakat diperlukan kemitraan dengan semua pihak, sehingga organisasi, program dan pengelola sumberdaya dapat meningkat serta berdaya saing.