bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemistry and Pharmacology of Zanthoxylum gilletii: A Review
Authors: Mbula J. P. , Kitete E. M. , Kasiama N. G. , Ngoyi E. M. , Kwembe J. T. K. , Tshilanda D. D. , Ngbolua K. N. , Tshibangu D. S. T. , Mihigo S. O. , Onautshu O. , Mpiana P. T. 
Published: November 2022

Aim: Zanthoxylum gilletii is used in traditional medicine against several pains, namely urinary tract infections, malaria, lombargy, high blood pressure etc. Thus, the aim of this study was to review the literature on the traditionnal use, the phytochemical composition and the biological activities of the above-mentioned plant.
Methodology: A literature review was conducted based on the scientific results sourced from Science Direct, PubMed, Google Scholar, SciLEO and PubMed Central. The plant scientific name was used as a search keyword together with the following words phytochemistry, pharmacology, bioactivity and pharmacognosia.
Results: Z. gilletii extracts have shown antimicrobial, antifungal, antiparasitic and anticancer activities. Several compounds have been reported from different parts of the plant including alkaloids, amides, coumarins and essential oils and have shown interesting biological properties such as the antioxidant and antimicrobial activities. However, there are, to date, several compounds whose biological activities are not known, especially that belonging to the essential oil class. At the same time, there are also the activities observed but for which the responsible compounds are unknown.
Conclusion: All parts of Z.gilletii are used in traditional medicine and decoction is the most recommended method of preparation. Data from phytochemical studies are quite poor, especially on essential oils.
The Peasant Agroalimentary Territories – Echoing Post-development?
Authors: Castillo O. L. , Salamanca Diana, 
Published: November 2022

Inequality in access to land in Latin America, has led several rural communities to design and implement alternative forms of territorial management. In this article the identification and analysis of the characteristics of the Peasant Agroalimentary Territories (TCA for its Spanish acronym), which is the most recent territorial planning proposal in Colombia is offered; it rapidly has spread throughout this country and seems to be putting into practice some of the principles of post-development.
Confronting the current “development” dynamics (massive extraction, production, consumption, and disposal), post-development is a current of thought, gaining strength in Latin America that proposes to recover economic and environmental principles for achieving a more inclusive and equitable world. Hence, and based mainly on primary information collected (between 2019 and 2022) through interviews with social leaders and TCA inhabitants, minutes from meetings, and private documentation of other events related to their promotion and implementation, their main features and the progress in their establishment are explained.
The comparison between the theoretical principles of post-development and the TCA practices offers enough evidence to conclude that the peasant communities involved with the TCA are close enough to questioning hegemonic discourses and practices of development, understood mainly as economic growth. Another conclusion is TCA have not been created as a one-size-fits-all recipe, but rather seek to be as flexible and diverse as necessary. This characteristic is particularly important since it makes them easily reproducible in other rural contexts, and they do not depend on the rural location of a country or global region, on the geographic or ecosystem context, or on the social group that wants to organize it; instead, TCA provide the opportunity to recover a series of values and actions that are an integral part of a global trend in search of a transition towards a balance between the rights of human societies and those of Nature.
Management of Glass of Milk Program and Satisfaction of Beneficiaries in a Province of Peru
Authors: Saavedra-Coronel José Carlos 
Published: November 2022

The Glass of Milk Program is a social and welfare program. The objective of this research was to determine the relationship between the management of the glass of milk program and the satisfaction of the beneficiaries in the province of Trujillo, in 2022. The research was applied, with a quantitative approach, and non-experimental design with correlational and transversal scope. The variables studied were the management of the glass of milk program and user satisfaction. The population was made up of 2282 beneficiaries of the Glass of Milk Program of the Province of Trujillo, 2022, and the sample was 191 beneficiaries of the Program. The survey technique was used and the questionnaire as an instrument. The relationship between the management of the glass of milk program and beneficiary satisfaction was evidenced. The level of management of the glass of milk program is perceived as medium-high. The satisfaction of the beneficiaries, according to their reception focuses on a medium level, in terms of punctuality, attention, distribution, and effectiveness were located at a high level.
Photosynthetic Activity, Nutrient Concentration, Yield and Soil Properties Altered by Long Term INM Practices of Knol-khol (Brassica oleracea var. gongylodes L.) under Acidic Inceptisols
Authors: Sahu Suman G. , Dash Ashish Kumar , Panda Narayan , Pattanayak Sushanta Kumar , Prusty Meenakhi , Mishra Ambika Prasad , Padhan Kshitipati , Nanda Sweta , Patra Bishnupriya 
Published: November 2022

A long-term field experiment was started in the campus of College of Agriculture, OUAT, Bhubaneswar, Odisha since kharif 2010 in a randomized block design with 08 treatments and three replications under a cereal-vegetable-pulse cropping system. Different observations on plant and soil parameters were taken during kharif 2018 to evaluate the performance of the test crop towards different package and practices followed. The test crop was Knol-khol, the 25th crop in the sequence. The treatments were T1: Control, T2: Soil Test Dose (STD), T3: STD + Farm Yard Manure (F), T4: STD + Vermicompost (VC), T5: STD + F + Biofertilizers (BFs), T6: STD + VC + BFs, T7: STD + F + L + BFs, and T8: STD + VC + L + BFs which consisted of different combinations of inorganic fertilizers, organic manures (FYM and vermicompost), ameliorant (lime) and biofertilizers. Knol-khol crop was grown in the experimental plot with different organic and inorganic fertilizers as per the treatment plans. Leaf samples from different treatments were collected at 45 days after planting (DAP). The economic yield was highest (3.44 t ha-1) in the treatment supplied with inorganic and organic source of nutrient with lime (T7) which was at par with T8 (3.34 t ha-1) whereas significantly higher than rest other treatments and lowest was obtained in STD (1.45 t ha-1). The highest values 2.68%, 1.11mg g-1 of fresh leaves and 46.34 were recorded for leaf nitrogen content, chlorophyll content and SPAD value respectively were recorded with treatment T7 whereas lowest value of 1.91%, 0.54 mg g-1 of fresh of leaves and 21.81 were recorded for leaf nitrogen content, chlorophyll content and SPAD value respectively with T1. However, the soil properties after harvest of the crop were found to be better with T8 where vermicompost was integrated with inorganic fertilizer and lime.
A Study on the Bangladeshi Mothers' Experiences with Intrauterine Fetal Death (IUFD)
Authors: Chowdhury Deep , Islam Sazin , Biswas Ripon , Jyoti Agro Bhowmik , Mukta Sonia Afroz , Islam Md. Shariful 
Published: November 2022

Background: IUFD (intrauterine fetal death/demise) is a devastating experience for moms. IUFD mothers run the danger of going through life feeling depressed, anxious, unhappy, and sorrowful. Therefore, it is essential to do research on how moms cope with such a terrible event.
Purpose: This study aimed to learn more about how mothers in Bangladesh dealt with intrauterine fetal death/demise (IUFD).
Methods: Using a phenomenological perspective, a purposive sample strategy was used to choose the seven informants for descriptive qualitative research. In-depth interviews were used to gather the data, which was then evaluated utilizing Colaizzi's approach.
Results: The findings revealed four key themes, including the mothers' reactions to a loss-such as painful and traumatic experiences—moral support received by the mother, unfavourable behaviour on the part of others, such as stigma and lack of support, and physical and psychological changes that interfere with the mothers' roles as wife and mother.
Conclusion: IUFD's past was very distressing for mothers, who were left with a heavy emotional weight. Support and therapeutic communication must thus be included in practice.
In-vitro Acaricidal Study of Calotropis Gigantea Methanolic Extracts against (Rhipicephalus (B.) microplus) Ticks in Udaipur, Rajasthan, India
Authors: Dixit Anuj , Manzer Hakim 
Published: November 2022

The present research was conducted to find out acaricidal efficacy of methanolic extracts of Calotropis gigantea against Rhipicephalus (Boophilus) microplus ticks in Udaipur (Rajasthan). Larval packet Test (LPT) and Adult Immersion Test (AIT) were used to evaluate acaricidal efficacy. A total of four concentrations of the Calotropis gigantea extract (12.5%, 25%, 50%, and 100%) were used along with one control group with twice replications for each concentration were used in the bioassay. The Highest efficacy in both in-vitro tests (AIT and LPT) was recorded in 100% methanolic extracts of Calotropis gigantea. The Calotropis gigantea methanolic extracts displayed the highest IO% at 100% concentration, which was determined to be 67.46% in AIT. The methanolic extracts at 100% concentration had a minimum reproductive index of 0.16. During the study, it was clear that AIT had a lower reproductive index and a higher percent oviposition inhibition. Calotropis gigantea methanolic extracts in LPT demonstrated the highest efficacy at 100% concentration, which was of 64%. The Larval mortality increased trend with increasing concentrations of plant extracts.
Factors Affecting Recurrence Rate of Urethral Stricture Following Internal Urethrotomy
Authors: Khan Sajan , Fawad Ahmed , Javed Atif 
Published: November 2022

Background: Urethral stricture (post-scarring contraction in the urethral mucosa) is among the most challenging clinical conditions in urology. In Pakistan, Urethral stricture is a high-volume disease and constitutes 4-5% of urology workload (majority of them being in the 3rd to 5th decade of life). Different urethral strictures have different management option depending upon site, size and number of recurrences. OIU is indicated for urethral stricture for small (1.5 cm) bulbar and membranous urethral stricture. However, recurrence of strictures after OIU is quite common (4 to 5%). It has been proposed that duration and size of catheter after OIU effects the recurrence rate. The foremost management choice is internal urethrotomy, but recurrences are common, and many believe that the duration and size of catheterization post internal urethrotomy may affect the recurrence rate.
Objective: To determine the factors affecting recurrence rates of urethral stricture after internal urethrotomy.
Methodology: It was Quasi Experimental Study conducted in Urology ward of Dr. Ziauddin University Hospital, Karachi from 10th March 2020 to 31 december 2021. Total 60 patients were included; all of the patients were divided into four equal groups. All the patients were followed quarterly for 12 months and data was recorded for urinary flow, retention, burning sensation during urination. UFM, Cystoscopy and urethrogram were done once indicated. Symptomatic patients or patients with UFM 15ml/sec were checked for recurrence followed by cystoscopy if needed. The data analysis was obtained using SPSS v. 21.0.
Results: The mean age of the sample stood at 27 (SD ± 4) years (range: 20 to 40) years were enrolled in the study. Urethral stricture disease recurred cumulatively in 24 (40%) patients within 12 months. Mean duration of catheterization was 8.71 ± 1.1 and 2.97 ± 0.91 days in patients with and without recurrences, respectively (p=0.001). Catheter dwell times for ≥7 days was associated with increased recurrence (p=0.039). Of the patients with recurrent strictures, increased catheter diameter was also associated with higher recurrence rates (p=0.041).
Conclusion: After careful consideration, it can be concluded that longer catheter in-dwell time and greater catheter diameter lead to a greater probability of stricture recurrence and hence the indwell time should be limited to ≤ 3 days and the catheter size chosen to be no more than 16Fr.
Isolation and Phenotypic Characterization of Lytic Bacteriophage with Activity against Pseudomonas aeruginosa
Authors: Nascimento Caroline Antunes do , Bertuol Milena Zanoello , Pasqualotto Luana , Püttov Elis Presser , Pilotto Fernando , Santos Luciana Ruschel dos , Rodrigues Laura Beatriz 
Published: November 2022

Aims: To perform the isolation and phenotypic characterization of bacteriophage with lytic activity against Pseudomonas aeruginosa. To demonstrate that this type of viral agent can be isolated from the environment and used for the biocontrol of resistant bacterial types, such as Pseudomonas aeruginosa.
Study Design: This study was an experimental study.
Place and Duration of Study: The study was conducted at, Bacteriology and Mycology Laboratory in the Veterinary Hospital at the School of Agricultural Sciences, Innovation and Business of the University of Passo Fundo (ESAN/UPF) and Center for Diagnosis and Research in Animal Health of the University of Passo Fundo (CDSA/UPF), between April 2022 and June 2022.
Methodology: Samples of untreated water were inoculated with the host bacterium strain Pseudomonas aeruginosa ATCC 27853 in an enriched media After the incubation period in, a phage filtrate was obtained by centrifugation followed by filtration. We verified the presence of bacteriophages using spot test and we carried out its purification by the method of sterile toothpick plate transfer on bacterial overlay semi-solid agar. Amplification was performed using an SM buffer elution procedure to produce a stock of viral material. Through assays in Petri dishes with bacterial overlay, we performed titration and phenotypic characterization regarding the lysis spectrum and efficiency of phage infection in the host.
Results: We managed to isolate a morphologically characterized lytic bacteriophage with approximately 1 mm of diameter, high clarity in the inhibition area, the presence of halo and well-demarcated edges. The bacteriophage, named as Pseudomonas aeruginosa Phage UPF_PaBP1, demonstrated the infection capacity of the target bacteria in all tested dilutions and a stock preparation with a titre of 6.5 x 10⁸ PFU/ml was obtained for future use.
Conclusion: The isolated phage showed strong lytic activity against the bacterial host, a finding that nourishes our expectations regarding the use of this phage as a biocontrol agent and phage therapy.
Analysis of Cardiovascular Complications During Delivery Admissions Among Patients With Systemic Lupus Erythematosus, 2004-2019
Authors: Zahid Salman , Mohamed Mohamed S. , Wassif Heba , Nazir Noreen T. , Khan Sadiya S. , Michos Erin D. 
Published: November 2022

ImportanceIndividuals with systemic lupus erythematosus (SLE) have an increased risk of pregnancy-related complications. However, data on acute cardiovascular complications during delivery admissions remain limited.ObjectiveTo investigate whether SLE is associated with an increased risk of acute peripartum cardiovascular complications during delivery hospitalization among individuals giving birth.Design, Setting, and ParticipantsThis population-based cross-sectional study was conducted with data from the National Inpatient Sample (2004-2019) by using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) or International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Clinical Modification (ICD-10-CM) codes to identify delivery hospitalizations among birthing individuals with a diagnosis of SLE. A multivariable logistic regression model was developed to report an adjusted odds ratio (OR) for the association between SLE and acute peripartum cardiovascular complications. Data were analyzed from May 1 through September 1, 2022.ExposureDiagnosed SLE.Main Outcomes and MeasuresPrimary study end points were preeclampsia, peripartum cardiomyopathy, and heart failure. Secondary end points included ischemic and hemorrhagic stroke, pulmonary edema, cardiac arrhythmias, acute kidney injury (AKI), venous thromboembolism (VTE), length of stay, and cost of hospitalization.ResultsA total of 63 115 002 weighted delivery hospitalizations (median [IQR] age, 28 [24-32] years; all were female patients) were identified, of which 77 560 hospitalizations (0.1%) were among individuals with SLE and 63 037 442 hospitalizations (99.9%) were among those without SLE. After adjustment for age, race and ethnicity, comorbidities, insurance, and income level, SLE remained an independent risk factor associated with peripartum cardiovascular complications, including preeclampsia (adjusted OR [aOR], 2.12; 95% CI, 2.07-2.17), peripartum cardiomyopathy (aOR, 4.42; 95% CI, 3.79-5.13), heart failure (aOR, 4.06; 95% CI, 3.61-4.57), cardiac arrhythmias (aOR, 2.06; 95% CI, 1.94-2.21), AKI (aOR, 7.66; 95% CI, 7.06-8.32), stroke (aOR, 4.83; 95% CI, 4.18-5.57), and VTE (aOR, 6.90; 95% CI, 6.11-7.80). For resource use, median (IQR) length of stay (3 [2-4] days vs 2 [2-3] days; P &amp;lt; .001) and cost of hospitalization ($4953 [$3305-$7517] vs $3722 [$2606-$5400]; P &amp;lt; .001) were higher for deliveries among individuals with SLE.Conclusions and RelevanceThis study found that SLE was associated with increased risk of complications, including preeclampsia, peripartum cardiomyopathy, heart failure, arrhythmias, AKI, stroke, and VTE during delivery hospitalization and an increased length and cost of hospitalization.
Photothermal Enhanced and Tumor Microenvironment Responsive Nanozyme for Amplified Cascade Enzyme Catalytic Therapy
Authors: Zhu Yang , Pan Yuanbo , Guo Zhengxi , Jin Duo , Wang Wenyu , Liu Manman , Zong Mingxi , Zheng Xinwei , Wu Yun , Wang Lulu , Tian Changlin , Cheng Junjie , Liu Yangzhong 
Published: November 2022

AbstractNanocatalysts, a class of nanomaterials with intrinsic enzyme‐like activities, have been widely investigated for cancer catalytic therapy in recent years. However, precise construction of nanocatalysts with excellent enzyme catalytic activity and biosafety for tumor therapy still remains challenging. Here, a biodegradable nanocatalyst, PEGylated CuxMnySz (PCMS), is reported that can promote cascade catalytic reactions in tumor microenvironment (TME) while confining off‐target side effects on normal tissues. PCMS not only catalyzes the cascade conversion of endogenous hydrogen peroxide (H2O2) to oxygen (O2) via catalase‐like activity and then to superoxide radical (·O2−) via oxidase‐like activity in the TME, but also effectively depletes intracellular glutathione via glutathione oxidase‐like activity. The cascade catalytic reactions, by taking advantage of high H2O2 level in tumor cells, result in an enhanced enzyme catalytic effect in generation of ·O2−. More importantly, PCMS exhibits prominent photothermal effect under NIR‐II 1064 nm laser irradiation that can further enhance chemodynamic therapy (CDT) efficacy in tumors. In addition, the biodegradation in TME and excellent photothermal effect of PCMS are beneficial to magnetic resonance imaging, photoacoustic imaging and infrared thermal imaging, resulting in tracing the fate of PCMS in vivo. This study provides a new tool for rational design of TME‐responsive nanocatalysts with high biocompatibility for tumor catalytic therapy.
Nanodroplet‐Coated Microbubbles Used in Sonothrombolysis with Two‐Step Cavitation Strategy
Authors: Pan Yunfan , Li Yongjian , Li Yan , Zheng Xiaobing , Zou Chenghong , Li Jiang , Chen Haosheng 
Published: November 2022

AbstractThrombosis is a major cause of morbidity and mortality and sonothrombolysis is a promising method for its treatment. However, the slow diffusion of the thrombolytic agents into the thrombus results in slow recanalization. Here, nanodroplet‐coated microbubbles (NCMBs) are designed and fabricated and a two‐step cavitation strategy is used to accelerate the thrombolysis. The first cavitation of the NCMBs, cavitation and collapse of the microbubbles induced by low frequency ultrasound, drives the nanodroplets on the shell into the thrombus, while the second cavitation, the phase‐change and volume expansion of drug‐loaded nanodroplets triggered by high frequency ultrasound, loosens the thrombus by the sono‐porosity effect. This two‐step cavitation of the NCMBs is verified using a fibrin agarose model, where a rapid diffusion of the thrombolytic agents is observed. Furthermore, the NCMBs reach much higher thrombolysis efficiency in both in vitro and proof‐of‐concept experiments performed with living mice. The nanodroplet‐coated microbubbles are a promising diffusion medicines carrier for efficient drug delivery.
Synthesis of MAPbBr3‐Polymer Composite Films by Photolysis of DMF: Toward Transparent and Flexible Optical Physical Unclonable Functions (PUFs) with Hierarchical Multilevel Complexity
Authors: Minh Duong Nguyen , Nguyen Lan Anh Thi , Nguyen Quynh H. , Vu Thanh Van , Choi Jinwoo , Eom Sangwon , Kwon S. Joon , Kang Youngjong 
Published: November 2022

AbstractPhysical entities with inherent randomness have been investigated as anti‐counterfeiting labels based on physical unclonable functions (PUFs). Herein, a transparent and flexible optical PUF label associated with multilevel complexity is demonstrated by taking advantage of the optical properties of hierarchical morphologies of the composite film composed of metal halide perovskite nanoparticles (MAPbBr3 NPs) and the intrinsic spinodal‐decomposition‐like phase separation of polymer blend (PMMA/PS blend). Due to the combinatorial effects of the photolysis synthesis of MAPbBr3 and the thermodynamic instability of the PMMA/PS blend, randomized patterns emerge at two‐level scales. These patterns are intrinsically non‐deterministic, and therefore, the PUF labels from the multilevel random patterns are challenging to replicate. This is mainly attributed to random spot patterns (higher‐level patterns) confined within intricate bicontinuous patterns (lower‐level patterns).