bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation
Authors: Acklin Scarlett , Sadhukhan Ratan , Du Wuying , Patra Mousumi , Cholia Ravi , Xia Fen 
Published: June 2022

Abstract

Background
Chemotherapy-induced peripheral neuropathy represents a major impairment to the quality of life of cancer patients and is one of the most common dose-limiting adverse effects of cancer treatment. Despite its prevalence, no effective treatment or prevention strategy exists. We have previously provided genetic evidence that the NAD+-dependent deacetylase, SIRT2, protects against cisplatin-induced peripheral neuronal cell death and neuropathy by enhancing nucleotide excision repair. In this study, we aimed to examine whether pharmacologic activation of SIRT2 would provide effective prevention and treatment of cisplatin-induced peripheral neuropathy (CIPN) without compromising tumor cell cytotoxic response to cisplatin.

Methods
Using von Frey and dynamic hot plate tests, we studied the use of nicotinamide riboside (NR) to prevent and treat CIPN in a mouse model. We also performed cell survival assays to investigate the effect of NAD+ supplementation on cisplatin toxicity in neuronal and cancer cells. Lewis lung carcinoma model was utilized to examine the effect of NR treatment on in vivo cisplatin tumor control.

Results
We show that NR, an NAD+ precursor and pharmacologic activator of SIRT2, effectively prevents and alleviates CIPN in mice. We present in vitro and in vivo genetic evidence to illustrate the specific dependence on SIRT2 of NR-mediated CIPN mitigation. Importantly, we demonstrate that NAD+ mediates SIRT2-dependent neuroprotection without inhibiting cisplatin cytotoxic activity against cancer cells. NAD+ may, in fact, further sensitize certain cancer cell types to cisplatin.

Conclusions
Together, our results identify SIRT2-targeted activity of NR as a potential therapy to alleviate CIPN, the debilitating and potentially permanent toxicity.
Two is not always better than one: ST-segment elevation myocardial infarction and acute pulmonary embolism in COVID-19
Authors: Radhakrishna Avinash , Abdelaziz Mohammed Omar , Mulvihill Niall 
Published: June 2022

Abstract
Coronavirus disease 2019 (COVID-19) has become a significant global health burden with potential consequences on the cardiovascular system. We describe a case of a healthy male with no prior cardiovascular risk factors who developed ST-segment elevation myocardial infarction and pulmonary embolism following a diagnosis of severe COVID-19 pneumonitis. The patient made a significant recovery following coronary thromboaspiration and anticoagulation therapy. Multiple mechanisms including an indirect hyperinflammatory immune response and/or direct endothelial damage may explain the prothrombotic state related to COVID-19. The cytokine storm leads to endothelial dysfunction and subsequent thromboembolism. Awareness of the lethal cardio-pulmonary sequalae of COVID-19 is important as surges continue across the world owing to new variants.
A case report of a large right atrial myxoma: the role of virtual consultations and imaging during the COVID-19 pandemic
Authors: Velvet Anju JJ , Parekh Vishal , Khan Waqas , Ahmed Irfan 
Published: June 2022

Abstract
We present a case report of a right atrial myxoma first diagnosed on a transthoracic echocardiogram after telephone consultations held in lieu of face-to-face consultations during the first wave of the COVID-19 pandemic. The echocardiogram was requested on the second telephone consultation 3 months after an initial presentation with a dry cough and fatigue due to new symptoms of palpitations and shortness of breath raising suspicion of heart failure. Virtual consultations continue to replace face-to-face consultations to avoid unnecessary exposure to COVID and reduce health care costs. This case report focuses on the importance of obtaining a systematic history, identifying red flags, referring to appropriate specialties and requesting the right investigations for early diagnosis and management of conditions with serious complications.
Neonatal venolymphatic malformation with spontaneous parotid duct rupture: first case report
Authors: Gamage Darshanika C T , Jayamanne Bernard Deepal Wanniarachchi , Quasim Syed Faizan , Kailidis Kosmos , Olabi Anas 
Published: June 2022

Abstract
Disorders of salivary glands especially the parotid gland very rare among neonates and children other than cytomegaly and parotitis epidermica. Venolymphatic malformations are very rare in children. Such presentation around the parotid region yet to be reported. This case report describes a rare presentation of a neonatal venolymphatic malformation on the parotid duct. A 4-week-old termly delivered male infant referred to by a general practitioner bruising over the left buccal area for 1 day from non-consanguine healthy parents. On examination a bluish discoloration in the buccal mucosa over a firm mildly tender area without signs of inflammation was seen. Ultrasound examination of the lesion showed fluid and solid soft tissue suggestive of haematoma and magnetic resonance imaging scan confirmed the rupture of the parotid duct with venolymphatic malformation. The child has been referred to the vascular malformation clinic and plastic surgical clinic in a tertiary care hospital for follow-up.
Carney complex with multiple breast tumours including breast cancer: a case report
Authors: Fujimoto Akihiro , Sakakibara Ayaka , Numajiri Yoshiki , Matsuura Kazuo , Kawasaki Tomonori , Osaki Akihiko , Saeki Toshiaki 
Published: June 2022

Abstract
Carney complex (CNC) is a rare multiple tumour syndrome characterized by cutaneous pigmented lesions, myxoma and endocrine tumours, among others, and is inherited as an autosomal dominant trait. Protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) is known to be the responsible gene. Breast myxomatosis and ductal adenoma, which are regarded as benign, are well-known mammary lesions of CNC and are included in the main diagnostic criteria. In this case, a 59-year-old woman with repeated cardiac myxoma was diagnosed with CNC with PRKAR1A mutation. She also had three multiple breast tumours bilaterally: breast cancer, adenomyoepithelioma and intraductal papilloma. In mammary lesions of CNC, attention should be paid to benign lesions, such as breast myxomatosis or ductal adenomas, and the development of breast cancer or breast tumours with malignant potential. Mammary lesions should be aggressively scrutinized and considered for resection, as required.
The heart of the matter: secretory pheochromocytoma presenting as recurrent biventricular heart failure (Takotsubo cardiomyopathy)
Authors: Turner Lauren M , Serraro-Brown Hazel , McLaren Mairi , Rachel Lau , Mosse Charles 
Published: June 2022

Abstract
Takotsubo’s syndrome (TS) is an acute, transient cardiomyopathy occurring secondary to physical or emotional stressors through catecholamine excess. Secretory pheochromocytomas have been previously implicated in cases of TS (PTS), however, often present atypically, are associated with reoccurrence, and have higher rates of complications. We describe the case of a 70-year-old female who presented central chest pain, hypotension and electrocardiogram changes on a background of a 6-month prior episode of resolved Takotsubo’s with unknown cause. After progressing to cardiogenic shock with biventricular failure, computerized tomography coronary aortogram revealed an incidental adrenal mass, later proven to be a secretory pheochromocytoma on biochemistry and subsequent histology. PTS has been associated with recurrence and rarely presents as cardiogenic shock. This case highlights the complexity of TS presentations and complications and the diagnostic delays that may occur in PTS.
Popular Music in Times of Neo-Liberalism and Beyond
Authors: Gedik Ali C. 
Published: June 2022

Abstract
This chapter discusses the struggles for cultural hegemony in Turkey as manifested in the practices of Turkish popular music by focusing on the last two decades of neoliberalism, roughly between years 2000–2020. This period corresponds to one of the most striking changes in the history of Turkey where the state and its institutions, and thus official ideology and popular culture, have been subject to a conspicuous neoliberal transformation. The theoretical framework of this study is based on an old Marxist antinomy between political economy and cultural studies approaches. Therefore, the theoretical premises of the relevant literature ranging from musical commodity to cultural hegemony are critically revisited based on the works of Marx, Gramsci, Adorno, Benjamin, Williams, and Hall. Finally, this chapter presents a theoretical framework for the study of popular music in times of neoliberalism within the context of the political economy of cultural hegemony where Turkish popular music is considered as a case study.
“Don’t Be Afraid to Pogo!”
Authors: Ríos-Hernández Marlén 
Published: June 2022

Abstract
Inspired by the early Los Angeles punk band the Gears and their seminal hit “Don’t Be Afraid to Pogo,” this chapter unearths a genealogy of the mosh pit as a window into an alternative Chicanx/Latinx punk historiography by way of its long-forgotten ties to the pogo. The missing link between the pogo and the mosh pit is one created out of the outright erasure of people of color from broader punk history, which has generally centered the experiences of cis-heterosexual white middle-class men. The author argues that the erasure of the Los Angeles punk scene and queer Chicana/Latina/black youth from punk history can be mapped through the story of when and how the pogo was replaced, or rather gentrified, by slamming, and later by the mosh pit. Guided by Diana Taylor’s notion of “cultural memory,” “intellectual dumpster diving” as method, and the oral testimonies with Chicana and Latina punks, the author shows how Latina and Chicana punks have redefined the dances they inherit, the white punk histories they both love and hate, and how they see ways to make the pit their own.
A Little Bit of Evil
Authors: Haider Najam 
Published: June 2022

Abstract
The city of Kūfa in southern ‘Irāq was home to myriad religious communities through the 2nd/8th and 3rd/9th centuries. All of these groups ascribed a particular importance to the Masjid Kūfa, located at the center of the city and attached to the governor’s complex. This chapter traces the evolution of the mosque in the religious imaginary of the Twelver Shī‘a who came to dominate Kūfa by the 5th/11th century. Rather than simply elide the mosque’s connection to political power or other religious groups, the Twelver Shī‘a tackled the space’s ambiguity head-on. For example, they integrated this ambiguity into the spatial distribution of the mosque itself, placing its footprint within a biblical narrative centered on Nūḥ (Noah). The end result was the demarcation of the Masjid Kūfa into discrete spaces, some of which were particularly blessed while others held problematic historical associations.
Mediated Spaces of Collective Ritual
Authors: Caidi Nadia , Karim Mariam 
Published: June 2022

Abstract
This chapter examines the contemporary manifestations of the pilgrimage tradition of Hajj and engages a deeper reflection on how Muslim pilgrims encounter and negotiate space(s)—both physical and virtual—in a globalized, hyperconnected era. The embodied experiences of Hajj pilgrims in Mecca, Saudi Arabia, are examined through the lens of artefacts produced and publicly shared with others on social-networking platforms. A visual-content analysis conducted on a sample of one hundred selfies taken at Hajj point to the work that these artefacts do in the context of the construction of affiliative identities among geographically dispersed communities of pilgrims. Our findings suggest that the selfies contribute to interrogating and complicating religious spaces. The heterotopic discursive fields opened by the sacred selfies may even constitute meaningful ritual spaces through a recentering around the devotee. Sacred selfies can thus be read as a tactic used to create opportunities for self-representation and community building.
Eastern Orthodox Spaces in America
Authors: Denysenko Nicholas 
Published: June 2022

Abstract
Eastern Orthodox architecture in America is diverse and draws from a variety of sources. Church buildings typically follow one of three patterns. The immigrant church model features architectural configuration that resembles the models from a community’s native homeland. Orthodox America experienced a wave of liturgical renewal in the second half of the twentieth century, and those principles inspired modifications in the architectural style for many parishes, contributing to the shape of the liturgical renewal model. Existing Christian styles influenced the Orthodox architectural form identified as the American church model. This chapter presents examples of each of the three models while discussing parallel patterns such as semipermanent missions and structures inspired by specific historical models.
Sacred Space in Nineteenth-Century Cape Town
Authors: Saloojee Ozayr 
Published: June 2022

Abstract
This chapter discusses a method of theorizing and interpreting the space and identity of the nineteenth-century Muslim community in the Bokaap neighborhood of Cape Town, South Africa. It suggests that it is through a radical empiricism of the spatial (a linking of ideas from postcolonial theory and religious studies) that the spaces of this community can be made more fully known or conceptualized in a different way. The outcome is a proposal for an emergent spatial framework for the study of Muslim space, developed through a methodology that links empirical research with a phenomenological heuristic. The framework suggests that an infrastructural, associative, contingent, and anticipatory reading of space might allow for new conceptions of sacred space.
(In)visible Priorities
Authors: Simonowitz David 
Published: June 2022

Abstract
Although the King ‘Abdullah Mosque, inaugurated in 1989, is perhaps the most recognizable ritual space in modern Amman, the important role of the inscriptions on the building is less apparent to observers who are unfamiliar with Arabic. This study shows how these inscriptions augment the dialogic potential and spatializing power of the ritual site. Key exterior epigraphs intertextually reference structures surrounding the mosque, drawing pedestrians into contemplative engagement with scriptural space and coloring conceptions of the national civic space for those passing them by more rapidly. As the chapter shows, when combined or deployed in different contexts, even well-known texts can take on novel meanings. In certain circumstances, however, they may also convey unanticipated messages. The municipal response to one such epigraphic anomaly reveals the underlying power of inscriptions, but also the contextual polysemy and instability of familiar texts.
The Hermeneutics of 21st-Century Sacred Space
Authors: Crosbie Michael J. 
Published: June 2022

Abstract
The current millennial generation in North America reflects different attitudes about the role of spirituality in their lives, and how that spirituality is expressed. According to recent studies, millennials often describe themselves as spiritual, not religious. There is greater focus on defining sacred space as “situational” versus “substantive” by which a space is made sacred through the interaction of human beings seeking the spiritual, as seen in the work of architect. This contrasts with the approach of many architects who believe that space is made sacred through the power of architectural design and that the architect acts as the creating agent. Other architects see their role in providing a place for sacred memory to reside, to create metaphors in the architecture for religious experience. This chapter presents a graduate architecture design studio that offered the author opportunities to explore new definitions of sacred space drawn from millennial students’ own experiences with the spiritual.
Women’s Mosques
Authors: Shiekh Irum 
Published: June 2022

Abstract
This chapter combines historical research and ethnographic fieldwork to examine the rituals of Friday prayer at the Women’s Mosque of America, based in Los Angeles, California. The research reveals that the mosque has provided women with opportunities to be fully involved in all aspects of prayer without placing any limitations on their bodies. This full participation has led to the emergence of new areas of inquiry within theological spaces that had gone unnoticed because of the absence of women in leadership and decision-making spaces. Through engaged discussions and practices, mosque-going women are widening the circles of female scholars in local communities, making the mosque instrumental in the development and dissemination of Islamic knowledge that deconstructs patriarchal interpretations of the Qur’an and empowers women.
Remnants of Israel
Authors: Streit Jessica Renee , Stiefel Barry L. 
Published: June 2022

Abstract
This chapter examines Jewish sacred spaces in medieval and Early Modern Europe by looking at case studies. As its point of departure, it affirms that sacred spaces are socially constructed, dynamic, and often multifunctional products of human creation that respond to the changing needs of the communities they serve. These ideas are addressed through the examination not only of spatial arrangements or ornamental programs of Jewish sacred space, but also of the ways in which it created, claimed, or negotiated sacred loci within the built environment. In this way, this chapter presents a complex and historically grounded picture of Jewish life and religious practice from the onset of the European Middle Ages, when Jews lost the opportunity for citizenship, to the beginning of their emancipation from these restrictions in the early nineteenth century.
Religious Place/Space in Premodern China
Authors: Lin Wei-Cheng 
Published: June 2022

Abstract
In premodern China, what made a place, as well as its space, religious was not inherent to that place. Rather, it required a particular construction, in both discourse and space, to turn an otherwise physical place into a spiritual one. Accordingly, this chapter argues that the religious place/space was not a prerequisite of religion, but a “production” of it. In this production, one sees how different methods were conceived and implemented to engage, manipulate, control, enact, or represent the religious place/space in premodern China as part of the religious practice. This chapter thus aims to analyze ways in which the religious place/space was constructed and produced so that it became fully interwoven into the fabric of the religion. To this end, it proposes considering religious place/space in premodern China in four different modalities of spatial construction: diagrammatic space, the sacred site, ritual space, and literary space.
Presence and Performance
Authors: Papalexandrou Amy 
Published: June 2022

Abstract
This chapter explores some of the ways in which sacredness was a human investment and substantive feature of the experience of the liturgy. Human society in the Eastern Roman Empire was seen as sacred and holy, and the Divinity was believed to be present and accessible through ritual in every church. In performative gestures the senses, especially sound, scent, and sight, each had a performative role to play. Icons were critical for personal worship, and monasteries were routinely visited by worshipers for devotion and prayer. Oratories donated by wealthy ktetors became a popular means of gaining access into heaven, and women “wrapped” village churches with rope during difficult times, especially when there was a plague. Local customs, experiential settings, and worship dominated life for those living in the Eastern Roman Empire.
Beyond the Rainbow
Authors: Ahessy Bill 
Published: June 2022

Abstract
While LGBTQIA+ older adults report that they are generally ageing well, past and present adversity, health disparities, and difficulties accessing affirmative care negatively impacts many. There has been increased attention to LGBTQIA+ perspectives in music therapy; nevertheless, LGBTQIA+ older adults have remained largely invisible. Music therapists report feeling unprepared and undereducated in working with LGBTQIA+ older adults, yet are likely to encounter them in aged-related settings, in which up to one-third of practitioners work. This chapter examines the historical contexts that older LGBTQIA+ adults experienced and highlights health disparities and barriers to affirmative care. It explores the role of music and music therapy, considers implications, and suggests methods and techniques for affirmative music therapy practice.
The Experimental Novel in Latin America
Authors: Kurz Andreas 
Published: June 2022

Abstract
This chapter deals with the unique practice of the Latin American experimental novel within the rise of postmodernist writing in Europe and in North America. A discussion of the particularities of experiment in literature is followed by a concise analysis of some postmodernist features postulated by Jean-François Lyotard, Brian McHale, and other theorists. Finally, three novels by Julio Cortázar, including Hopscotch, and some narrative texts by the Mexican experimental author Salvador Elizondo serve as illustrations and proof of the transcultural development in Latin American narrative that follows principles established by Fernando Ortiz and Ángel Rama. The most important outcome of the research is the necessity of accepting an independent postmodern way in Latin American writing that combines political and social focuses with formal and epistemological experiments.
The Nineteenth-Century Brazilian Novel and the Transcendence of Machado de Assis
Authors: Dixon Paul 
Published: June 2022

Abstract
As a former colony, Brazil imported literary values from Portugal and other European countries. In the nineteenth century, several Brazilian novelists successfully adapted the movements of romanticism, realism, and naturalism not only to their tropical flora and fauna, but also to the unique human confluence of the indigenous, European, and African races. Machado de Assis, more than any Brazilian novelist, showed an ability to transcend those prior forms and to create an esthetic of his own, with both national and universal currency. In his mature novels, Machado adopted a digressive, associative style that finds its inspiration in authors prior to realism or naturalism. He engaged in metafictional discourse, describing the dynamics of his own texts and of literary expression in general. And he created problematic narrators who challenge their audiences, inciting them to more independent ways of reading.
Social Realism, Indigenismo, and the Vindication of the Other
Authors: Pulido Herráez María Begoña 
Published: June 2022

Abstract
Social realism spread in Latin American literature between the 1920s and 1950s in response to the great social transformations of that period. The characteristics of social realism are defined not only in terms of content (a novel that describes the experiences of displaced, exploited, discriminated, and marginalized sectors, and aims to denounce and protest) but also in relation to the way in which the novel, as a genre, is appropriated, adapted, and transformed in relation to the processes it seeks to represent. Some of the key characteristics of social realist novels are the presence of collective characters, and a story told in a non-sequential chronology. Within the social realism of this period, indigenista novels stand out. The characteristics of the indigenista novel are studied by means of the concept of heterogeneity proposed by Antonio Cornejo Polar. Among the works analyzed are César Vallejo’s social realist novel El tungsteno and the indigenista novels El indio, by Gregorio López y Fuentes, and Huasipungo, by Jorge Icaza.