bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reziprozität – Kollegialität – Interdependenz. Sozialität von Kooperation in der Bildungsorganisation Schule
Authors: Dohmen Tobias , Stralla Michael 
Published: November 2022

ZusammenfassungDieser Beitrag in der ZeitschriftGruppe. Interaktion. Organisation. (GIO)verfolgt das Ziel, soziale (Erklärungs‑)Mechanismen schulinterner Kooperation zu identifizieren und diese entlang der Frage zu systematisieren, welche theoretischen Implikationen der Sozialität unter Lehrpersonen dabei bezogen auf das Entstehen und die Dynamik kooperativer Arbeitsbeziehungen in Schulen wirksam werden. Ausgangspunkt der Systematisierung sind vorliegende Konzeptualisierungen sowie die aktuelle Befundlage des Forschungsfeldes. In den mittlerweile zahlreich vorliegenden Forschungsarbeiten zur Kooperation von Lehrpersonen innerhalb der Bildungsorganisation Schule wird Kooperation in den vielfältigen theoretischen und methodischen Zugängen als eine Schlüsselkategorie im Zusammenhang mit schulqualitäts-, -entwicklungs- und -steuerungsorientierten Fragestellungen angenommen. In Anbetracht der Feststellung einer zunehmenden (Aus‑)Differenzierung des Binnengefüges von Schulen sowie der beanspruchten Erweiterung der Aufgabenbereiche von Lehrer*innen wird abschließend aufgezeigt, welche gestaltungsbezogenen Spezifizierungen der Erkenntnisse zu den kooperativen Arbeitsbeziehungen von Lehrer*innen sich angesichts gegenwärtiger Veränderungen der Schulen ableiten lassen.
Talcott Parsons’ normativfunktionalistische Theorie der (Bildungs‑)Organisation
Authors: Lischka-Schmidt Richard 
Published: November 2022

ZusammenfassungDieser Artikel der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) schlägt ein neues Verständnis von Talcott Parsons’ Theorie der (Bildungs‑)Organisation vor, indem sie als normativfunktionalistisch betrachtet wird. Ausgangspunkt ist die Annahme, dass normative Kultur fundamental für Parsons’ gesamte Theorie ist. Darauf aufbauend wird Parsons’ Theorie der (Schule als) Organisation aufgearbeitet, für die das normativkulturelle Verhältnis von Akteur*innen, Organisation und Umwelt zentraler Analysefokus ist. Schließlich wird am Beispiel von Inklusion gezeigt, dass dieser organisationstheoretische Zugang für die Analyse von Spannungen, mit denen Schule im Zuge von Inklusion konfrontiert ist, instruktiv ist.
Do start-ups benefit from coworking spaces? An empirical analysis of accelerators’ programs
Authors: Del Sarto Nicola , Ferrigno Giulio , Parida Vinit , Di Minin Alberto 
Published: November 2022

AbstractOpen innovation and innovation performance have been widely studied in the literature. However, few studies have examined the impact of openness to different types of external knowledge on start-ups’ innovation performance. Moreover, previous literature could be further complemented by additional investigation into how the coworking spaces provided by accelerator programs may engender informal sources of knowledge that enhance the innovation performance of accelerated start-ups. To address this research gap, we investigate whether start-ups participating in accelerator programs can enhance their innovation performance through information transfer from informal networks provided by business accelerator programs. In order to do so, we draw two-stage data collection data from 113 start-ups accelerated by Italian accelerators from 2013 to 2016 and the response data collected in 2018. Our results reveal that coopetitors, educators, and investors are beneficial for different innovation outcomes of accelerated start-ups. These findings contribute to the innovation management literature, the small business management literature, the literature on accelerators and the coworking spaces literature.
Efficacy and Safety of Biosimilar Romiplostim Versus Innovator Romiplostim in Patients with Chronic Immune Thrombocytopenia
Authors: Chandrakala S. , Toshniwal Manoj , Halvawala Mitesh , Padwal Namita , Sidharthan Neeraj , Malhotra Pankaj , Prashantha B. , Ballikar Riya , Shah Sandip , Apte Shashikant , Viswanathan T. Kasi , Ramanan Vijay , Sharma Akhilesh , Pawar Dattatray , Pawar Roshan , Shahavi Vinayaka 
Published: November 2022

AbstractRomiplostim is a Food and Drug Administration (FDA)-approved therapy for immune thrombocytopenia (ITP). Biosimilar is a biological product that has no clinical meaningful difference from an existing FDA-approved reference product. It has a potential of lowering health-care-related cost. Biosimilar of romiplostim can be made available to patients with ITP at a low cost and can be beneficial in providing the best therapy. Thus, the efficacy and safety of biosimilar romiplostim (ENZ110) was compared with innovator romiplostim (Nplate) with respect to platelet response in patients with chronic ITP. This was a prospective, multicenter, randomized, and double-blind clinical trial. Patients with chronic ITP, aged 18–65 years, were enrolled in a study and were randomized to receive either ENZ110 or Nplate in a 3:1 ratio for a treatment period of 12 weeks, respectively. After completion of the treatment period, the patients were followed-up for one week to evaluate the platelet response and to monitor the adverse events (AEs). Over the duration of 12 weeks, platelet response of > 50 × 109/L was achieved in 85.3% patients treated with ENZ110 and in 75.0% patients treated with Nplate in per protocol population. In intent-to-treat population, 83.8% patients with ENZ110 and 76.9% patients with Nplate achieved a platelet response of > 50 × 109/L. In the ENZ110 group, 111 AEs were recorded in 66.7% patients, while 18 AEs were reported in 61.5% patients in the Nplate group. The study demonstrated non-inferiority with comparable efficacy and safety between biosimilar romiplostim and innovator romiplostim in patients with chronic ITP.Trial registration number and date of registration: CTRI/2019/04/018614.
Impact of CDKN2A/B, MTAP, and TERT Genetic Alterations on Survival in IDH Wild Type Glioblastomas
Authors: Hsu Eric J. , Thomas Jamie , Maher Elizabeth A. , Youssef Michael , Timmerman Robert D. , Wardak Zabi , Dan Tu D. , Patel Toral R. , Vo Dat T. 
Published: November 2022

Abstract
Purpose
Poor outcomes in IDH wild-type (IDHwt) glioblastomas indicate the need to determine which genetic alterations can indicate poor survival and guidance of patient specific treatment options. We sought to identify the genetic alterations in these patients that predict for survival when adjusting particularly for treatments and other genetic alterations.

Methods
A cohort of 167 patients with pathologically confirmed IDHwt glioblastomas treated at our institution was retrospectively reviewed. Next generation sequencing was performed for each patient to determine tumor genetic alterations. Multivariable cox proportional hazards analysis for overall survival (OS) was performed to control for patient variables.

Results
CDKN2A, CDKN2B, and MTAP deletion predict for worse OS independently of other genetic alterations and patient characteristics (hazard ratio [HR] 2.192, p = 0.0017). Patients with CDKN2A copy loss (HR 2.963, p = 0.0037) or TERT mutated (HR 2.815, p = 0.0008) glioblastomas exhibited significant associations between radiation dose and OS, while CDKN2A and TERT wild type patients did not. CDKN2A deleted patients with NF1 mutations had worse OS (HR 1.990, p = 0.0540), while CDKN2A wild type patients had improved OS (HR 0.229, p = 0.0723). Patients with TERT mutated glioblastomas who were treated with radiation doses < 45 Gy (HR 3.019, p = 0.0010) but not those treated with ≥ 45 Gy exhibited worse OS compared to those without TERT mutations.

Conclusion
In IDHwt glioblastomas, CDKN2A, CDKN2B, and MTAP predict for poor prognosis. TERT and CDKN2A mutations are associated with worse survival only when treated with lower radiation doses, thus potentially providing a genetic marker that can inform clinicians on proper dose-fractionation schemes.
Classifying exploratory experimentation – three case studies of exploratory experimentation at the LHC
Authors: Mättig Peter 
Published: November 2022

AbstractAlong three measurements at the Large Hadron Collider (LHC), a high energy particle accelerator, we analyze procedures and consequences of exploratory experimentation (EE). While all of these measurements fulfill the requirements of EE: probing new parameter spaces, being void of a target theory and applying a broad range of experimental methods, we identify epistemic differences and suggest a classification of EE. We distinguish classes of EE according to their respective goals: the exploration where an established global theory cannot provide the details of a local phenomenon, exploration of an astonishing discovery and exploration to find a new entity. We find that these classes also differ with respect to the existence of an identifiable target and their impact on the background theory. The characteristics distinguish EE from other kinds of experimentation, even though these different kinds have not yet been systematically studied. The formal rigor and precision of LHC physics facilitates to analyze concept formation in its early state. In particular we emphasize the importance for nil–results for conceptualization and argue that conceptualization can also be achieved from nil–results only.
Dissolved oxygen concentration and eutrophication evaluation in Yamchi dam reservoir, Ardabil, Iran
Authors: Hanjaniamin Amin Esmaeilzadeh , Tabrizi Mahdi Sarai , Babazadeh Hossein 
Published: November 2022

AbstractOne of the essential issues in the quality management of water resources is the determination of the level of eutrophication and dissolved oxygen in dam reservoirs and other water bodies. It is possible to study changes in dissolved oxygen concentration using qualitative models. In this study, CE-QUAL-W2, a two-dimensional model of hydrodynamics and water quality capable of predicting the behavior of aquatic ecosystems, has been used to simulate dissolved oxygen concentration and eutrophication. As a case study, the water quality of the Yamchi dam reservoir, located in Ardabil Province, has been qualitatively investigated using the CE-QUAL-W2 model. Based on the geographical location of the Yamchi dam reservoir, it includes warm monomictic basins. According to the results, the dissolved oxygen concentration in the simulation period varied between 0 and 12 mg/L. In autumn and winter, this concentration was almost uniform at various depths. However, in summer, a sharp decrease in dissolved oxygen concentration, to less than 2 mg/L in the bottom layers, was observed, which is due to the presence of nutrients. Regarding eutrophication, the Yamchi dam reservoir is one of the eutrophic reservoirs, and practical strategies should be employed to improve these conditions. Recommended strategies include reducing the retention time of water in the reservoir, dewatering from the underlying layers during the thermal stratification period, and preventing the entry of agricultural drains into the inlet tributaries of the reservoir.
Use of evolutionary computation and guide curves to optimize the operating policies of a reservoir system established to supply drinking water
Authors: Carmona-Paredes Rafael Bernardo , Domínguez-Mora Ramón , Arganis-Juárez Maritza Liliana , Juan-Diego Eduardo , Mendoza-Ramírez Rosalva , Carrizosa-Elizondo Eliseo 
Published: November 2022

AbstractThe objective of the present study was to develop a genetic algorithm capable of establishing optimal operating policies for monthly extractions from the three main reservoirs of the Cutzamala System, which supply drinking water to the Mexico City metropolitan area. In previous studies, annual water extraction defined with an annual Z curve in terms of the total water storage in the reservoirs on November 1 was optimized using genetic algorithms. In this study, a percentage of total annual extraction for each reservoir was also optimized, but monthly water extractions were adjusted too, when the water level fell outside the upper or lower limits of guide curves stablished for each reservoir. The capabilities of the genetic algorithms combined with a detailed simulation of reservoirs operation were used to optimize the levels of the guide curves and also to optimize the adjusted monthly programed extractions as linear functions of the difference between the actual storage level at the beginning of each month and the corresponding level of the guide curves. Therefore, 90 parameters were established: four to define the Z curve, two to establish the percentage assigned to each reservoir, 72 to establish the monthly levels of the guide curves and 12 to define the parameters of the linear functions used to adjust the monthly programed extractions when the actual water level exceeds the limits of the guide curves. For each alternative of the 90 parameters, a detailed simulation is done using the last 20 years of hydrological data on the inflow of water to the three main reservoirs, including the net contributions of five diversion dams, and the objective function sought to maximize water delivery to the treatment plant, while penalizing possible spills and deficits in the system is evaluated. The optimal policies found in this research resulted in smaller spills than those that occurred during the historical operation of the reservoir system. Therefore, the optimal monthly operating decisions required for each reservoir are provided by the genetic algorithm.
Numerical model of seepage flows by reformulating finite element method based on new spherical Hankel shape functions
Authors: Farmani Sajedeh , Ghaeini-Hessaroeyeh Mahnaz , Hamzehei-Javaran Saleh 
Published: November 2022

AbstractThe water penetration in soil is investigated numerically using the finite element method (FEM) in a novel way. In the suggested method, new spherical Hankel shape functions are used and the finite element method is reformulated based on them. These new functions are obtained from the first and second kind of Bessel functions. The properties of Hankel shape functions lead to having more accuracy and robustness for the proposed method with low number of elements. To validate the suggested approach, at first, a boundary value problem is solved and the results are compared with the available analytical solution. Then, in order to prove the efficiency and applicability of the present model in the seepage problems, five examples including saturated and unsaturated flow in porous media are studied and the hydraulic head is calculated. Afterward, the results obtained from the classical and new method are compared together. The comparisons indicate that the suggested method with the low number of elements is more precise than the classic FEM with the same mesh.
Numerical solution of the three-dimensional Burger’s equation by using the DQ-FD combined method in the determination of the 3D velocity of the flow
Authors: Rezaei Iman , Vaghefi Mohammad 
Published: November 2022

AbstractIn this paper, the differential quadrature and the finite difference combined method (DQ-FDM) was applied to solve the three-dimensional Burger’s equation in the determination of the 3D velocity of the flow; so that spatial terms were discretized by the differential quadrature method, and the temporal term was discretized by the finite difference method, and the resulting nonlinear equations were solved using the Newton–Raphson method. All variables were considered as dimensionless in this equation. The solution results were compared with solution results of the two-dimensional equation in the two other numerical methods available in the literature which provided an acceptable accuracy. Also, the results of the mentioned numerical method were compared with those of the fully implicit finite difference method that was solved for larger than or equal viscosities of 0.1. The results showed that by increasing time and viscosity, the longitudinal, depth and transverse velocities were decreased. The occurrence of the upward flow was observed especially in the $$\upsilon$$
υ
= 0.05 in the close of the bed, end of the length and width that in the presence of very fine particles of the clay and silt shows suspension of these particles in some spaces. The position of the longitudinal, depth and transverse velocities in the plan for the passing plates through the section depth for different viscosities and times showed that by increasing viscosity and time, the position of the maximum velocities became closer to the middle of the section width. Also, stream lines were plotted in all of sections and then analyzed.
Evaluation of the controllability of a remotely piloted high-altitude platform in atmospheric disturbances based on pilot-in-the-loop simulations
Authors: Hasan Yasim J. , Roeser Mathias S. , Voigt Andreas E. 
Published: November 2022

AbstractIn the context of the project HAP, the German Aerospace Center (DLR) is currently developing a solar-powered high-altitude platform that is supposed to be stationed in the stratosphere for 30 days. The development process includes the design of the aircraft, its manufacturing and a flight test campaign. Furthermore, a high-altitude demonstration flight is planned. While the high-altitude flight will be performed using a flight control and management system, during take-off and landing and at the beginning of the low-altitude flight test campaign, the aircraft will be remotely piloted. The aircraft has a wing span of 27 m and operates at extremely low airspeeds, being in the magnitude of around 10 m/s equivalent airspeed, and is therefore profoundly susceptible to atmospheric disturbances. This is particularly critical at low altitudes, where the airspeed is lowest. Hence, both time and location for take-off, landing or low-altitude flight test campaigns need to be selected thoroughly to reduce the risk of a loss of aircraft. In this regard, the knowledge about the operational limits of the aircraft with respect to atmospheric conditions is crucial. The less these limits are known, the more conservative the decision about whether to perform a flight on a certain day or not tends to be. On the contrary, if these limits have been adequately investigated, the amount of days and locations that are assessed as suitable for performing a flight might increase. This paper deals with a pilot-in-the-loop simulation campaign that is conducted to assess the controllability of the high-altitude platform in atmospheric disturbances. Within this campaign, the pilots are requested to perform practical tasks like maintaining track or altitude, flying a teardrop turn or performing a landing while the aircraft is subject to different atmospheric disturbances including constant wind, wind shear, continuous turbulence, and discrete gusts of different magnitudes. This paper describes the desktop simulator used for the campaign, outlines the entity of investigated test points and presents the assessment method used to evaluate the criticality of the respective disturbances. Finally, a set of restrictions on the acceptable wind conditions for the high-altitude platform are found. The underlying limits comprise a constant wind speed of 3.0 m/s in any direction, except during landing, maximum wind shear of 0.5 $$\text { m/s}^{2}$$

m/s
2

and gusts with peak speeds of 1.5 to 2.0 m/s, depending on the direction.
Robotic versus laparoscopic distal pancreatectomy on perioperative outcomes: a systematic review and meta-analysis
Authors: Li Pengyu , Zhang Hanyu , Chen Lixin , Liu Tiantong , Dai Menghua 
Published: November 2022

AbstractRobotic surgery has become a promising surgical method in minimally invasive pancreatic surgery due to its three-dimensional visualization, tremor filtration, motion scaling, and better ergonomics. Numerous studies have explored the benefits of RDP over LDP in terms of perioperative safety and feasibility, but no consensus has been achieved yet. This article aimed to evaluate the benefits and drawbacks of RDP and LDP for perioperative outcomes. By June 2022, all studies comparing RDP to LDP in the PubMed, the Embase, and the Cochrane Library database were systematically reviewed. According to the heterogeneity, fix or random-effects models were used for the meta-analysis of perioperative outcomes. Odds ratio (OR), weighted mean differences (WMD), and 95% confidence intervals (CI) were calculated. A sensitivity analysis was performed to explore potential sources of high heterogeneity and a trim and fill analysis was used to evaluate the impact of publication bias on the pooled results. Thirty-four studies met the inclusion criteria. RDP provides greater benefit than LDP for higher spleen preservation (OR 3.52 95% CI 2.62–4.73, p < 0.0001) and Kimura method (OR 1.93, 95% CI 1.42–2.62, p < 0.0001) in benign and low-grade malignant tumors. RDP is associated with lower conversion to laparotomy (OR 0.41, 95% CI 0.33–0.52, p < 0.00001), and shorter postoperative hospital stay (WMD − 0.57, 95% CI − 0.92 to − 0.21, p = 0.002), but it is more costly. In terms of postoperative complications, there was no difference between RDP and LDP except for 30-day mortality (RDP versus LDP, 0.1% versus 1.0%, p = 0.03). With the exception of its high cost, RDP appears to outperform LDP on perioperative outcomes and is technologically feasible and safe. High-quality prospective randomized controlled trials are advised for further confirmation as the quality of the evidence now is not high.
Considerations on the Systematics of Neotropical Pierina, with the Description of Two New Species of Phulia Herrich-Schäffer from the Peruvian Andes (Lepidoptera: Pieridae, Pierinae, Pierini)
Authors: Pyrcz Tomasz W. , Willmott Keith R. , Lamas Gerardo , Boyer Pierre , Florczyk Klaudia , Fåhraeus Christer , Mahecha Oscar , Cerdeña José , Mrozek Artur , Farfán Jackie , Zubek Anna 
Published: November 2022

AbstractA comparative analysis of high-Andean Pierina was carried out, including a total of 25 species. Based on morphological evidence, with an emphasis on venation and genitalia and molecular data, using three genetic markers, we confirm the recent subjective synonymy of the generic names Tatochila Butler, 1870, Piercolias, Staudinger, 1894, Hypsochila Ureta, 1955, Infraphulia Field, 1958, Pierphulia Field, 1958, and Theochila Field, 1958 with Phulia Herrich-Schäffer, 1867. Two new species are described, namely Phulia stoddardi Pyrcz & Cerdeña n. sp., from the Andes of Central Peru, which occurs at an unusually high altitude of close to 5000 m a.s.l. in dry puna habitat, and Phulia phantasma Lamas, Willmott & Boyer n. sp., from dry montane forests in northern Peru and southern Ecuador. An overview of high-elevation butterflies is presented, with some discussion on adaptations to this environment.
Biology of house dust mites and storage mites
Authors: Bergmann Karl-Christian 
Published: November 2022

SummaryHouse dust mites and storage mites have a high allergenic potential and lead to sensitization through the formation of specific IgE antibodies. Due to their preferred residence in houses, they belong to the group of house mites, which are referred to as “domestic mites” in English. Their anatomy and biology account for their amazing adaptability to changing environmental situations (including temperature, humidity, food) and make it understandable that measures to reduce their abundance are usually difficult to implement in practice.