bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms
Authors: Li Dan-ning , Lian Teng-hong , Zhang Wei-Jiao , Zhang Ya-nan , Guo Peng , Guan Hui-ying , Li Jing-hui , He Ming-yue , Zhang Wen-jing , Zhang Wei-jia , Luo Dong-mei , Wang Xiao-min , Zhang Wei 
Published: December 2022

BackgroundNeuropsychiatric symptoms (NPSs) belong to a category of non-motor symptoms of Parkinson's disease (PD), which seriously compromise the quality of life and prognosis of PD. This study focused on the correlations between NPSs, free radicals, neuroinflammatory factors, and neuropathological proteins in cerebrospinal fluid (CSF) in patients with PD, aiming to provide insights into the potential mechanisms and therapeutic target for PD with NPSs (PD-NPSs).MethodsIn total, 129 patients with PD were enrolled and assessed by the Neuropsychiatric Symptoms Inventory (NPI); they were divided into the PD-NPSs group (75 patients) and PD with no NPSs (PD-nNPSs) group (54 patients). The levels of hydrogen peroxide (H2O2) and nitric oxide (NO), and hydroxyl radical (·OH), anti-oxidative enzyme, neuroinflammatory factors, and neuropathological proteins in CSF from patients with PD were measured. The levels of the above variables were compared between PD-NPSs and PD-nNPSs groups, and correlation analyses among the above variables were conducted.Results(1) The levels of H2O2 and NO in CSF from the PD-NPSs group were significantly elevated compared with the PD-nNPSs group (p = 0.001), and NPI score positively correlated with the levels of H2O2 and NO (r = 0.283, P = 0.001; r = 0.231, P = 0.008). Reversely, total superoxide dismutase (tSOD) activity in CSF from the PD-NPSs group was significantly reduced compared with the PD-nNPSs group (p = 0.011), and negatively correlated with NPI score (r = −0.185, p = 0.036). (2) The tumor necrosis factor (TNF)-α level in CSF from the PD-NPSs group was significantly decreased compared with the PD-nNPSs group (p = 0.002) and negatively correlated with NPI score (r = −0.211, p = 0.016). (3) The total tau (T-tau) level in CSF from the PD-NPSs group was significantly higher than in the PD-nNPSs group (p = 0.014) and positively correlated with the NPI score (r = 0.167, p = 0.060). (4) The levels of H2O2 and NO positively correlated with the T-tau level in CSF from the PD-NPSs group (r = 0.183, p = 0.039; r = 0.251, P = 0.004), and the levels of TNF-α and T-tau showed a negative correlation (r = −0.163, p = 0.067).ConclusionOxidative distress characterized by the elevations of H2O2 and NO levels may closely correlate with the neurodegeneration in brain regions related to PD-NPSs. Thus, therapeutic antioxidants may become an important target for PD-NPSs therapy.
Decompressive craniectomy: Comparative analysis between surgical time and better prognosis
Authors: Bem Junior Luiz Severo , Silva Ana Cristina Veiga , Menezes Marcelo Diniz de , Galvão Maria Júlia Tabosa de Carvalho , Ferreira Neto Otávio da Cunha , Alencar Neto Joaquim Fechine de , Rabelo Nicollas Nunes , Almeida Nivaldo Sena , Valença Marcelo Moraes , Azevedo Filho Hildo Rocha Cirne de 
Published: December 2022

BackgroundMalignant ischemic stroke is characterized by the involvement of 2/3 of the area of the middle cerebral artery, associated with cerebral edema, intracranial hypertension (ICH) and cerebral herniation, generating high morbidity and mortality. Over the years, several therapies have been studied in an attempt to reverse or reduce the damage caused by this vascular disorder, including decompressive craniectomy (DC), a surgical technique reserved for cases that evolve with refractory ICH.MethodsThis study seeks to perform a comparative analysis on the effectiveness of decompressive craniectomy using four randomized clinical trials and the results found in the retrospective study conducted in a neurosurgical reference center between 2010 and 2018.ResultsThe total sample consisted of 263 patients, among which 118 were randomized and 145 were part of the retrospective study. The outcome was analyzed based on the modified Rankin Scale (mRS) for 6 and 12 months. The mean time to perform the DC was 28.4 h in the randomized trials, with the late approach (&gt; 24 h) associated with unfavorable outcomes (mRS between 4 and 6).ConclusionCompared to the aforementioned studies, the study by Bem Junior et al. shows that a surgical approach in &lt; 12 h had a better outcome, with 70% of the patients treated early classified as mRS 2 and 3 at the end of 12 months (1). Decompressive craniectomy is currently the most effective measure to control refractory ICH in cases of malignant ischemic stroke, and the most appropriate approach before surgery is essential for a better prognosis for patients.
Bi-objective goal programming for balancing costs vs. nutritional adequacy
Authors: Koenen Melissa F. , Balvert Marleen , Fleuren Hein 
Published: December 2022

IntroductionLinear programming (LP) is often used within diet optimization to find, from a set of available food commodities, the most affordable diet that meets the nutritional requirements of an individual or (sub)population. It is, however, not always possible to create a feasible diet, as certain nutritional requirements are difficult to meet. In that case, goal programming (GP) can be used to minimize deviations from the nutritional requirements in order to obtain a near feasible diet. With GP the cost of the diet is often overlooked or taken into account using the ε-constraint method. This method does not guarantee to find all possible trade-offs between costs and nutritional deficiency without solving many uninformative LPs.MethodsWe present a method to find all trade-offs between any two linear objectives in a dietary LP context that is simple, does not solve uninformative LPs and does not need prior input from the decision maker (DM). This method is a bi-objective algorithm based on the NonInferior Set Estimation (NISE) method that finds all efficient trade-offs between two linear objectives.ResultsIn order to show what type of insights can be gained from this approach, two analyses are presented that investigate the relation between cost and nutritional adequacy. In the first analysis a diet with a restriction on the exact energy intake is considered where all nutrient intakes except energy are allowed to deviate from their prescription. This analysis is especially helpful in case of a restrictive budget or when a nutritionally adequate diet is either unaffordable or unattainable. The second analysis only relaxes the exact energy intake, where the other nutrients are kept within their requirements, to investigate how the energy intake affects the cost of a diet. Here, we describe in what situations the so-called more-for-less paradox takes place, which can be induced by requiring an exact energy intake.ConclusionTo the best of our knowledge, we are the first to address how to obtain all efficient trade-offs of two linear objectives in a dietary LP context and how this can be used for analyses.
Study protocol of an open-label prospective phase II umbrella study of precise neoadjuvant therapy for patients with stage II-IIIB resectable non-small cell lung cancer (PURPOSE)
Authors: Wang Yiyang , Zhai Haoran , Wang Jiaming , Mao Teng , Ji Chunyu , Bao Feichao , Gu Zhitao , Fang Wentao 
Published: December 2022

BackgroundThe outcomes of locally advanced non-small cell lung cancer (LA-NSCLC) are unfavorable mainly due to a high risk of cancer recurrence. Only around 5% of patients can benefit from perioperative chemotherapy which is the current standard treatment. Recently, promising results with neoadjuvant targeted and immune-therapy therapy have been seen. However, most clinical trials are looking for patients eligible for certain drugs, instead of seeking suitable treatments for certain patients. Therefore, it is necessary to look for more efficient perioperative therapies to increase resectability, reduce recurrence and improve prognosis.Methods/DesignThe study is an open-label, prospective, phase II, umbrella trial, enrolling patients diagnosed with treatment-naïve potentially resectable Stage II-IIIB NSCLC. Next-generation sequencing (NGS) using a 68-gene panel is performed for biopsies of tumor tissues from eligible patients. Enrolled patients are then stratified into six independent cohorts based on the status of gene mutations and PD-L1 status in tumor tissues, that is, ①EGFR 19del group, ②EGFR 21 L858R group, ③EGFR rare mutation group, ④Other driver mutation group, ⑤Drive mutation-negative group with PD-L1≥1%, ⑥Drive mutation-negative group with PD-L1&lt;1%. A Simon’s two-stage design is performed in each cohort independently and patients receive corresponding standard therapies accordingly. We aim to enroll 26 patients in each cohort and totally 156 patients will be enrolled. The primary endpoint is objective response rate (ORR). Secondary endpoints include oncological prognosis and perioperative outcomes. Exploratory endpoint is to investigate patient-specific minimal residual disease (MRD) in predicting treatment efficacy and oncological prognosis.DiscussionsThis is the first umbrella trial focusing on the safety and efficacy of precise neoadjuvant therapy for patients diagnosed with potentially resectable LA-NSCLC based on NGS results. The results of this trial would help improve overall treatment results in LA-NSCLC patients.Trial registrationChinese Clinical Trial Registry. Trial registration number: ChiCTR2100053021.Advantages and limitations of this studyThere is no neoadjuvant umbrella trial focusing on LA-NSCLCs. This is the first neoadjuvant umbrella trial, using a precise individualized approach and seeking suitable drugs for LA-NSCLC patients, with the aim to improve overall treatment outcomes.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR2100053021.
Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinoma
Authors: Zhang Chenyue , Wang Kai , Liu Wenjie , Lin Jiamao , Li Zhenxiang , Wang Hui , Zhao Chenglong , Chen Yanhua , Wu Shuangxiu , Yang Airong , Wu Jiayan , Wang Haiyong 
Published: December 2022

BackgroundAs a rare subtype of primary lung adenocarcinoma (LUAD), mucinous pulmonary adenocarcinoma (MPA) was considered a distinctive entity with unfavorable outcomes. Therefore, there is a great need for a better understanding of the genomic and immunological landscape of this rare tumor type, which would inform improved therapeutic strategies.MethodsA total of 96 patients histologically confirmed with MPA were recruited from Shandong Cancer Hospital and Institute (SCH). Single nucleotide variation (SNV), copy number variation (CNV), genomic instability, and immunological landscape insights into 96 MPA patients were identified using WES.ResultsWe demonstrated that MPAs had marked different genomic alterations and were more complex in genomic profiles than LUADs. Mutations in Tumor Protein 53 (TP53) and CYP7A Promoter-Binding Factor (CPF) pathways significantly shortened survival whereas mutations in Notch and Wnt pathways significantly prolonged survival in MPA. Besides, we demonstrated that mutations in immune-related genes influenced outcomes, with mutations in TP53, Ataxia Telangiectasia Mutated (ATM), Polymerase (DNA) Delta 1 (POLD1), and Epidermal Growth Factor Receptor (EGFR) correlated with worsened survival.ConclusionsWe not only depicted the genetic and immunologic landscape of Chinese MPA but also reveal its distinction from LUAD in genomic and immune context. Our findings may provide opportunities for therapeutic susceptibility among Chinese MPA patients.
Comparative changes of health-promoting phytochemicals and sugar metabolism of two hardy kiwifruit (Actinidia arguta) cultivars during fruit development and maturity
Authors: Lin Yuanxiu , Tang Honglan , Zhao Bing , Lei Diya , Zhou Xuan , Yao Wantian , Fan Jinming , Zhang Yunting , Chen Qing , Wang Yan , Li Mengyao , He Wen , Luo Ya , Wang Xiaorong , Tang Haoru , Zhang Yong 
Published: December 2022

IntroductionHardy kiwifruit (Actinidia arguta) has an extensive range of nutritional and bioactive compounds and has been valued as a great resource for kiwifruit breeding. A better understanding of the dynamic changes of the composition and accumulation of nutritional compounds during fruit development and ripening is required before genetic or cultural improvements can be targeted.MethodsIn the present study, the phytochemical analysis of two A. arguta cultivars ‘Yilv’ and ‘Lvmi-1’ showed that they comprised different morphology, with a higher fruit diameter while a lower vertical fruit diameter of ‘Lvmi-1’ compared with ‘Yilv’. The antioxidant capacity of both cultivars decreased during the maturity time and showed no significant difference between them. Furthermore, although glucose gradually increased during the maturity time, the predominant sugar composition was speculated to be fructose in ‘Lvmi-1’ fruit while sucrose in ‘Yilv’ fruit at the early fruit developmental stages. Moreover, the predominant acids in ‘Yilv’ and ‘Lvmi-1’ were citric acid followed by quinic acid, malic acid, and oxalic acid. The expression of sugar- and starch-related genes encoding the crucial enzymes suggested different changes in ‘Yilv’ and ‘Lvmi-1’. Notably, a subsequent correlation analysis showed a significant positive correlation between sucrose phosphate synthase (SPS) expression and glucose in ‘Yilv’, fructokinase (FK) expression, and starch content in ‘Lvmi-1’, implying their vital roles in sugar and starch accumulation. By contrast, a significant negative correlation between FK expression and fructose in ‘Lvmi-1’ fruit was observed.Results and DiscussionIn summary, our results provide supplementary information for the dynamic changes of nutritional compounds and antioxidant capacity during hardy kiwifruit maturity time and give a clue for exploring the mechanism of sugar and starch accumulation in hardy kiwifruit.
Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11
Authors: Kevin Richard C. , Cairns Elizabeth A. , Boyd Rochelle , Arnold Jonathon C. , Bowen Michael T. , McGregor Iain S. , Banister Samuel D. 
Published: December 2022

IntroductionSynthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances that have been associated with multiple instances and types of toxicity. Some SCRAs appear to carry a greater toxicological burden than others, or compared to the prototypical cannabis-derived agonist Δ9-tetrahydrocannabinol (Δ9-THC), despite a common primary mechanism of action via cannabinoid 1 (CB1) receptors. “Off-target” (i.e., non-CB1 receptor) effects could underpin this differential toxicity, although there are limited data around the activity of SCRAs at such targets.MethodsA selection of 7 SCRAs (AMB-FUBINACA, XLR11, PB-22, AKB-48, AB-CHMINICA, CUMYL-PINACA, and 4F-MDMB-BUTINACA), representing several distinct chemotypes and toxicological profiles, underwent a 30 μM single-point screen against 241 G protein-coupled receptor (GPCR) targets in antagonist and agonist mode using a cellular β-arrestin recruitment assay. Strong screening “hits” at specific GPCRs were followed up in detail using concentration-response assays with AMB-FUBINACA, a SCRA with a particularly notable history of toxicological liability.ResultsThe single-point screen yielded few hits in agonist mode for any compound aside from CB1 and CB2 receptors, but many hits in antagonist mode, including a range of chemokine receptors, the oxytocin receptor, and histamine receptors. Concentration-response experiments showed that AMB-FUBINACA inhibited most off-targets only at the highest 30 μM concentration, with inhibition of only a small subset of targets, including H1 histamine and α2B adrenergic receptors, at lower concentrations (≥1 μM). AMB-FUBINACA also produced concentration-dependent CB1 receptor signaling disruption at concentrations higher than 1 μM, but did not produce overt cytotoxicity beyond CP55,940 or Δ9-THC in CB1 expressing cells.DiscussionThese results suggest that while some “off-targets” could possibly contribute to the SCRA toxidrome, particularly at high concentrations, CB1-mediated cellular dysfunction provides support for hypotheses concerning on-target, rather than off-target, toxicity. Further investigation of non-GPCR off-targets is warranted.
Paycheck Protection Program (PPP) COVID-19 relief funding for veteran-, minority-, and women- owned dental businesses: A cross-sectional study
Authors: Alpert Elizabeth , Boynes Sean G. , Shaver Amber , Cothron Annaliese 
Published: December 2022

BackgroundThe Covid-19 pandemic exacerbated dental staffing shortages, which impact care delivery and ultimately oral health equity. Federal funding efforts like the Paycheck Protection Program (PPP) sought to aid traditionally underserved businesses including those owned by veterans, minority racial and ethnic groups, and women.Objectives(1) To examine differences in PPP funding between veteran- and nonveteran-owned dental care delivery businesses and organizations and (2) to analyze other relevant factors associated with variation in PPP funding levels for dental businesses.MethodsUsing publicly available PPP data, we ran unadjusted bivariable and adjusted multivariable linear regression models to estimate associations between loan approval amount and forgiveness amount, veteran status, and relevant covariates.ResultsMinority racial and ethnic groups and women received less PPP funding and less loan forgiveness, on average, compared with non-minority groups. In the adjusted model with no missing self-reported demographic observations atp &lt; 0.10, veterans received more PPP funding and loan forgiveness, on average, compared to non-veterans.ConclusionTo our knowledge, this is the first comprehensive analysis of all dental recipients of PPP funding throughout the United States. Despite PPP program intentions and strategies, traditionally underserved dental businesses did not receive increased funding to support employment.
The future of auroral E-region plasma turbulence research
Authors: Huyghebaert Devin , Billett Daniel , Chartier Alex , Chau Jorge L. , Hussey Glenn C. , Hysell David L. , Ivarsen Magnus F. , Mesquita Rafael L. A. , Rojas Enrique , Vierinen Juha , Young Matthew 
Published: December 2022

The heating caused by ionospheric E-region plasma turbulence has documented global implications for the energy transfer from space into the terrestrial atmosphere. Traveling atmospheric disturbances, neutral wind motion, energy deposition rates, and ionospheric conductance have all been shown to be potentially affected by turbulent plasma heating. Therefore it is proposed to enhance and expand existing ionospheric radar capabilities and fund research into E-region plasma turbulence so that it is possible to more accurately quantify the solar-terrestrial energy budget and study phenomena related to E-region plasma turbulence. The proposed research funding includes the development of models to accurately predict and model the E-region plasma turbulence using particle-in-cell analysis, fluid-based analysis, and hybrid combinations of the two. This review provides an expanded and more detailed description of the past, present, and future of auroral E-region plasma turbulence research compared to the summary report submitted to the National Academy of Sciences Decadal Survey for Solar and Space Physics (Heliophysics) 2024–2033 (Huyghebaert et al., 2022a).
PENINGKATAN KEMAMPUAN GURU DALAM PENGGUNAAN APLIKASI KOMPUTER BAGI GURU-GURU MADRASAH ALIYAH AL-FADILLAH
Authors: Nurhayati Sri 
Published: December 2022

Kegiatan pengabdian pada masyarakat ini bertujuan untuk meningkatkan kemampuan para guru dalam menggunakan aplikasi komputer dalam hal ini Microsoft office untuk mendukung pembelajaran di sekolah. Penerapan teknologi informasi dan komunikasi akan membuat proses atau kegiatan yang dilakukan menjadi lebih cepat, mudah, dan efisien. Saat ini penggunaan teknologi informasi dan komputer dalam dunia pendidikan memberikan dampak yang baik dalam mendukung proses pembelajaran di sekolah. Dengan kondisi ini tentunya akan menuntut para guru MA Al-Fadilah untuk dapat menggunakan aplikasi komputer dalam proses proses pembelajaran seperti bahan ajar, olah nilai siswa, dan lainnya. Namun tidak semua guru dapat menggunakan aplikasi komputer untuk membuat bahan ajar. Metode yang digunakan dalam kegiatan pengabdian ini berupa pelatihan, diskusi, dan simulasi yang dilakukan melalui daring dengan menggunakan aplikasi Zoom Meeting. Materi pelatihannya berupa aplikasi komputer yaitu Microsoft Office 2013 untuk proses pembelajaran. Setelah dilakukan pelatihan maka kegiatan ini menghasilkan bahwa adanya peningkatan kemampuan guru sebesar 15 % dalam menggunakan aplikasi komputer yaitu Microsoft Office 2013 untuk mendukung proses pembelajaran di sekolah.
PEMBANGUNAN SISTEM INFORMASI KEUANGAN PERUSAHAAN DI PARC C COFFEE & EATERY
Authors: Alfurqon Moch Azzi 
Published: December 2022

Parc C Coffee & Eatery merupakan sebuah usaha yang tergolong besar, perusahaan yang di dalamnya terdiri dari usaha caffe, co-working space, dan studio berlokasi di Jl. Kidang Pananjung No. 5C Dago Kota Bandung buka setiap hari dari jam 10.00 WIB hingga 22.00 WIB. Parc-C terinspirasi oleh getaran hangat Prancis dari "parc cafÃ©" yang menjadi ide utama membangun cafÃ© terbaik dan paling nyaman di Bandung.
Pada pengabdian ini digunakan metodologi penelitian berupa metode deskriptif. Sedangkan untuk metode pengumpulan data menggunakan metode wawancara, observasi, dan studi dokumentasi. Kemudian menganalisa dan menjelaskan data yang dikumpulkan sesuai dengan tujuan pengabdian untuk pembangunan sistem yang digunakan metode waterfall, dan untuk pemodelan sistem menggunakan metode perancangan orientasi objek dengan alat bantu perancangan yaitu flowmap, dan use case, dan kamus data. Dalam pengabdian ini menggunakan bahasa pemrograman PHP dengan menggunakan framework Codeigniter untuk membuat program dan menggunakan MySQL sebagai database.
Tujuan dari pengabdian ini diharapkan dapat mempermudah dalam mengelola administrasi keuangan perusahaan menjadi lebih cepat, tepat dan akurat. Setelah sesuai dengan metode penelitian yang diinginkan, sistem informasi ini memiliki tindak lanjut pengujian sistem dimana pengujian ini menggunakan metode black box.
PELATIHAN MS ACCESS UNTUK PETUGAS ADMINISTRASI DI RW 08 BUMI ADIPURA BANDUNG
Authors: Anthara I Made Aryantha , Andriani Diana , Ramadhan Ahmad Akbar , Adiningrat Muhammad Yusuf 
Published: December 2022

Teknologi informasi merupakan hal yang penting dalam kondisi globalisasi seperti saat ini. Pemanfaatannya dapat digunakan dalam berbagai macam kegiatan. Dalam pengabdian masyarakat ini akan menggunakan salah satu jenis dari teknologi informasi yang ada yaitu penggunaan sistem informasi yang berbasis Microsoft Access.Tempat yang dijadikan objek dalam pengabdian masyarakat kali ini adalah RW 08 yang terletak di Perumahan Bumi Adipura Bandung. Pada saat ini, pelayanan terhadap warga dalam hal pembuatan surat pengantar dan pembayaran iuran warga masih menggunakan cara tradisional. Hal ini dapat berpengaruh terhadap lamanya pelayanan kepada warga.Untuk dapat mempercepat proses pelayanan terhadap warga, maka dalam kegiatan pengabdian masyarakat ini akan diadakan pelatihan Ms Access kepada petugas administrasi yang ada di lingkungan tersebut.Tujuan yang diharapkan dalam kegiatan ini diantaranya dapat memberikan pemahaman kepada petugas administrasi untuk dapat menggunakan system informasi sehingga pelayanan kepada warga bisa lebih cepat.Metode yang digunakan dalam kegiatan ini adalah menggunakan metode daring dengan menggunakan aplikasi ZOOM dengan peserta yang berasal dari pengurus setempat, petugas administrasi dan juga instruktur pelatihan. Kendala yang dihadapi selama pelatihan, diantaranya masih kurangnya pemahaman dari petugas administrasi terhadap sistem informasi yang sudah dibuat. Dengan adanya sistem informasi ini, diharapkan pelayanan terhadap warga akan lebih cepat sehinga proses administrasi di RW 08 bisa berjalan lebih baik lagi.