bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds
Authors: Herron Karena 
Published: November 2022

Objective: Complex hard-to-heal wounds are difficult to manage, generating significant expense to the US healthcare system, costing nearly $25 billion annually. Recently, a resorbable synthetic nanofibre matrix was trialled on a variety of complex hard-to-heal wounds at Astria Sunnyside Hospital to assess clinical efficacy. Method: In this case series, five patients with multiple comorbidities presented in both the inpatient and outpatient setting with various hard-to-heal refractory wounds, including a venous leg ulcer (n=1), a diabetic foot ulcer (n=1), a Charcot foot deformity (n=1) and pressure ulcers (n=2). In an effort to treat these hard-to-heal wounds using a different treatment modality, each patient was transitioned to a care regimen utilising the synthetic nanofibre matrix. Results: Each patient, regardless of wound type, exhibited the formation of granulation tissue and a reduction in wound size. The application of this synthetic nanofibre matrix also resulted in tissue coverage over exposed structure in three cases, reduction of wound exudate in two cases, and eliminated a recurring infection with and without antibiotics in four cases. Conclusion: In this study, the treatment of hard-to-heal refractory wounds with the synthetic nanofibre matrix resulted in the desired biological responses and new tissue formation. Inclusion of the nanofibre matrix in inpatient and outpatient wound care settings may provide a much-needed solution for costly, difficult-to-treat, hard-to-heal wounds, and may offer a reduction in the total cost of care.
Role of platelet indices as diagnostic and predictive biomarkers for comorbidity of diabetes and metabolic syndrome in southern Ethiopia: A comparative cross-sectional study
Authors: Haile Kassahun , Kedir Rebie , Timerga Abebe , Mose Ayenew , Arkew Mesay 
Published: November 2022

Background
Metabolic syndromes (MetS) and diabetes mellitus (DM) comorbidity is a growing major global public health problem with huge morbidity and mortality. It is a pro-inflammatory and prothrombotic disorder characterized by alteration of platelet indices and increased platelet activation, however, the tendency to use them in diagnosis is not yet fully evaluated in our context and there is limited evidence on the role of platelet indices in predicting and differentiating DM+MetS comorbidity in Ethiopia. Thus, this study aimed to evaluate platelet indices in HC, DM, and DM+MetS, and to determine their role in the prediction of DM+MetS comorbidity risk and the distinction between DM+MetS and DM or healthy persons in southwest Ethiopia.

Method and materials
A comparative cross-sectional study was conducted in Wolkite University specialized hospital from March to August 2021. A total of 336 study participants (112 healthy controls (HC), 112 DM, 112 DM+MetS) was included in this study. Anthropmetric data were measured and the venous blood sample was collected to determine platelet indices, lipid profiles, and blood glucose levels. The SPSS version 21 statistical software was used to perform receiver operating curve (ROC), one-way ANOVA, and independent T-test analysis. The p-value for statistical significance was set at <0.05.

Result
In the present study, we found a significant difference in the mean value of PLT, MPV, and PDW between DM+MetS, DM, and HC. A statistically significant difference in the mean value of MPV and PDW was observed between HC and DM+MetS as well as DM and DM+MetS (p-value<0.001). At the cutoff value of 9.65fl with a sensitivity of 81.3% and a specificity of 67.9%, MPV differentiates DM+MetS from HC with an AUC of 0.859. MPV can differentiate DM+MetS from DM at a cutoff value of 10.05fl with sensitivity, specificity, and an AUC of 67.9%, 65.2%, and 0.675, respectively. At the cutoff value of 9.65fl with a sensitivity of 69.6% and a specificity of 67.9%, MPV differentiates DM from HC with an AUC of 0.747. The best platelet parameter identified in this study for predicting the presence of DM+MetS comorbidity was MPV (AUC=0.859; 95%CI=0.81-0.90).

Conclusion
In this study, a significant difference in the mean value of PLT, MPV, and PDW was found between DM+MetS, DM, and HC. The mean value of platelet indices showed significant increases in DM+MetS patients in comparison to HC and DM. MPV has been identified as a good potential marker to predict DM+MetS comorbidity and to differentiate DM+MetS comorbidity from the HC or DM. Our results show that MPV could be a good hematological marker to differentiate DM+MetS comorbidity from the HC or DM, and may offer supportive information for early diagnosis, prevention, and control. Thus, the findings of this study should be taken into account for the prevention and control of DM+MetS comorbidity.
Die globalistische Elite gegen das Volk. Antisemitismus und rechtspopulistisches Elitenbild
Authors: Roepert Leo 
Published: November 2022

Abstract
In the social sciences, it is often argued that in right-wing populism anti-Semitism does not play an important role and that cultural racism has taken over its function. In contrast, this article aims to show that right-wing populism reproduces anti-Semitic patterns in a codified form. First, it will be shown that problematic definitions and explanatory approaches are widespread in social science discourse, which contribute to the fact that the anti-Semitic content of right-wing populism is barely perceived. Subsequently, by analyzing two case studies – an essay by AfD politician Alexander Gauland and a speech by Donald Trump – it is shown that right-wing populist discourses asserting a struggle between the people and the »globalist elite« reproduce anti-Semitic patterns even though »Jews« are not explicitly mentioned. Finally, it is argued that this phenomenon can be grasped with the concept of structural anti-Semitism. With this term, it can be made clear that right-wing populism indeed has an anti-Semitic potential and that the contents and functions of anti-Semitism and racism must be distinguished.
Welfare Effects of Socially Conscious Platforms in Two-Sided Markets
Authors: Abe Hayama , Zennyo Yusuke 
Published: November 2022

Abstract
This note presents a model of platform competition in a two-sided market, with one competing platform pursuing not only its own profit but also consumer surplus. We investigate how the presence of such a socially conscious platform affects market competition. Results indicate that greater emphasis as an objective put on consumer surplus by the socially conscious platform leads to higher market share. Creation of a larger network enhances the total benefits associated with indirect network externalities in the two-sided market. When the extent of indirect network externalities is sufficiently strong, increased network benefits can improve social welfare. By contrast, if indirect network externalities are weak, then the socially conscious platform might be detrimental to society.
Evolution of thyroid cancer biomarkers: from laboratory test to patients’ clinical management
Authors: Garo Maria Luisa , Campennì Alfredo , Petranovic-Ovcaricek Petra , D’Aurizio Federica , Giovanella Luca 
Published: November 2022

Abstract
Over the past three decades, laboratory medicine has significantly evolved thanks to technological advances made possible by new materials and evidence. Clinicians’ ongoing requests for powerful, rapid, and minimally invasive tests has led manufacturers to develop rapid, accurate, and sensitive tests that can increase diagnostic accuracy and improve follow-up, bringing laboratory medicine ever closer to personalized medicine. The aim of this study was to critically review the main problems of the current Tg and CT biomarkers for the diagnosis/monitoring of DTC and MTC, respectively, and to identify the advantages and challenges of using the new laboratory biomarkers in the clinical management of patients with differentiated and medullary thyroid cancer. Insufficient harmonization of Tg and CT assays and lack of interchangeability of laboratory results and cutoff values pose challenges for comparability and standardization of procedures and methods. New diagnostic and monitoring approaches such as PCT or the Tg doubling time have proven to be effective. Close collaboration between clinicians and laboratory specialists remains essential to translate the advantages and limitations of current assays into appropriate clinical interpretation criteria. Over the years, the journal Clinical Chemistry and Laboratory Medicine (CCLM) has taken many steps to develop advanced research and technology in the diagnosis and monitoring of tumor cancer and to help clinicians translate it into clinical practice.
Finite Element Approximations for PDEs with Irregular Dirichlet Boundary Data on Boundary Concentrated Meshes
Authors: Pfefferer Johannes , Winkler Max 
Published: November 2022

Abstract
This paper is concerned with finite element error estimates for second order elliptic PDEs with inhomogeneous Dirichlet boundary data in convex polygonal domains.
The Dirichlet boundary data are assumed to be irregular such that the solution of the PDE does not belong to

H
2

⁢

(
Ω
)

{H^{2}(\Omega)}

but only to

H
r

⁢

(
Ω
)

{H^{r}(\Omega)}

for some

r
∈

(
1
,
2
)

{r\in(1,2)}

. As a consequence, a discretization of the PDE with linear finite elements exhibits a reduced convergence rate in

L
2

⁢

(
Ω
)

{L^{2}(\Omega)}

and

H
1

⁢

(
Ω
)

{H^{1}(\Omega)}

. In order to restore the best possible convergence rate we propose and analyze in detail the usage of boundary concentrated meshes. These meshes are gradually refined towards the whole boundary. The corresponding grading parameter does not only depend on the regularity of the Dirichlet boundary data and their discrete implementation but also on the norm, which is used to measure the error. In numerical experiments we confirm our theoretical results.
Effect of pipe rotation on heat transfer to laminar non-Newtonian nanofluid flowing through a pipe: a CFD analysis
Authors: Meesala Sai Kiran , Govinda Rao Budda , Yellapragada Datta Bharadwaz 
Published: November 2022

Abstract
The present numerical study is aimed at investigating the effect of rotation on heat transfer to non-Newtonian nanofluid flowing through a pipe. Non-Newtonian fluid flow under laminar condition with heat transfer finds the applications in various industries like food processing, pharmaceutical and polymer etc. Various proportions (1–3%) of copper nanoparticles are mixed with water to study the heat transfer rates non-Newtonian nanofluid flowing through the rotating pipe. Effect of rotation rate on heat transfer rates are also studied. In this study for 1% nanofluid at a constant rotation rate of 0.8, the Nusselt number is increased by 119.45%. The highest thermal performance factor (TPF) is 1.74, observed at N = 0.8, Pe = 5000, and for 1% volume concentration of non-Newtonian nanofluid.
Isomorphisms of Orlicz spaces
Authors: Tabatabaie Seyyed Mohammad , Latifpour Mahdi 
Published: November 2022

Abstract
In this paper, we provide some isomorphism preserving conditions for (weighted) Orlicz spaces, and as a main result, it is proved that if there exist a bicontinuous linear operator

T
:

L

w
1

Φ

⁢

(

G
1

)

→

L

w
2

Φ

⁢

(

G
2

)

{T\colon L^{\Phi}_{w_{1}}(G_{1})\rightarrow L^{\Phi}_{w_{2}}(G_{2})}

and a mapping

a
↦

(

ξ
⁢

(
a
)

,

h
⁢

(
a
)

)

{a\mapsto(\xi(a),h(a))}

from

G
1

{G_{1}}

to

ℂ
×

G
2

{\mathbb{C}\times G_{2}}

with

T
⁢

λ
a

=

ξ
⁢

(
a
)

⁢

λ

h
⁢

(
a
)

⁢
T

{T\lambda_{a}=\xi(a)\lambda_{h(a)}T}

for all

a
∈

G
1

{a\in G_{1}}

, then

G
1

{G_{1}}

and

G
2

{G_{2}}

are isomorphic, where Φ is a

Δ
2

{\Delta_{2}}

-regular Young function,

G
1

{G_{1}}

and

G
2

{G_{2}}

are locally compact groups and

w
1

{w_{1}}

and

w
2

{w_{2}}

are weight functions. Also, for a class of Young functions Φ, we show that if

C
⁢

V
Φ

⁢

(

G
1

)

{CV_{\Phi}(G_{1})}

and

CV
Φ

⁢

(

G
2

)

{\mathrm{CV}_{\Phi}(G_{2})}

are isometrically isomorphic, then

G
1

{G_{1}}

and

G
2

{G_{2}}

are isomorphic,

CV
Φ

⁢

(

G
i

)

{\mathrm{CV}_{\Phi}(G_{i})}

is the space of all convolution operators on the Orlicz space

L
Φ

⁢

(

G
i

)

{L^{\Phi}(G_{i})}

for

i
=

1
,
2

{i=1,2}

.
Spectrality of homogeneous Moran measures on ℝ
n
Authors: Fu Yan-Song , Tang Min-Wei 
Published: November 2022

Abstract
A Borel probability measure on

ℝ
n

{\mathbb{R}^{n}}

is called a spectral measure if the Hilbert space

L
2

⁢

(
μ
)

{L^{2}(\mu)}

has an orthonormal basis consisting of exponentials. In the present paper we show that, under a mild condition, compatible pairs and lacunary sequences generate homogeneous Moran spectral measures μ on

ℝ
n

{\mathbb{R}^{n}}

. As a consequence we show that compatible pairs are necessary and sufficient conditions for certain planar homogeneous Moran measures to become spectral ones.
How vector space models disambiguate adjectives: A perilous but valid enterprise
Authors: Montes Mariana , Geeraerts Dirk 
Published: November 2022

Abstract
The present study is part of a larger research project developing computational tools for large-scale corpus-based semantic analyses. One such tool represents semantic structure with vector space models (VSMs). The paper shows that this tool and the models built require a deeper understanding, especially with a view to how its results relate to cognitive theories of meaning. Although token-based VSMs are increasingly used in corpus-based cognitive semantics, we believe it is insufficiently appreciated how alternative parameter settings deal with a range of semantic issues, such as granularity of meaning, prototypicality of the domain of application and interaction with syntactic patterns. For the purpose of this paper, we will focus on only one of those issues, viz. the prototypicality of the domain of application, presenting the results of three of our case studies on the Dutch adjectives heilzaam, hoekig, hachelijk and geldig. The models presented are built from a 520MW corpus of contemporary Dutch and Flemish newspapers and by varying parameters such as window size, part-of-speech and frequency thresholds in the selection of features. The resulting VSMs are evaluated through visual analytics: although multidimensional, they can be reduced to 2D and represented in scatterplots where more similar tokens appear closer to each other. The color-coding with manual sense tags employed here makes it possible to compare the groupings provided by human annotators with those of the computational models in a way consistent with the cognitive approach to meaning and categorization.
Lexical Integrity: A mere construct or more a construction?
Authors: Cappelle Bert 
Published: November 2022

Abstract
This paper reviews the so-called Lexical Integrity Principle, resting on the assumption that morphology and syntax are distinct components of grammar. In the forty-odd years since its original formulation, this principle has repeatedly come under fire. Phrasal compounds ([[Lexical Integrity]NP
Principle]N being an example!) are often adduced as counterevidence, but I here argue that phrases generally don’t appear inside compounds and that the principle therefore cannot be so easily discarded. The claim that parts of words cannot be syntactically manipulated has remained relatively unchallenged, which is another reason to uphold some aspects of Lexical Integrity. The separability of particle verbs, though, presents a well-known potential problem. I address recent voices that particle verbs, despite neuroscientific evidence of their lexical status, are not words, maintaining they can be items with word status, given for example their occurrence in the [V the Ntaboo-word
out of NP] construction. A constructionist approach to alternation phenomena offers a solution to the separability issue, which consists in having schematic particle verb constructions whose grammatical status (and not just word order) is underspecified. As words, particle verbs stay together; as phrases, their parts can separate. To salvage the Lexical (or, better, Morphological) Integrity of words, this paper proposes a principle –a construction of sorts – that is a generalization emerging from how we use words.
Cognitive Linguistics meets Interactional Linguistics: Language development in the arena of language use
Authors: Behrens Heike , Pfänder Stefan 
Published: November 2022

Abstract
We take as our point of departure the usage-based assumption that grammar emerges from language use and briefly review the claims regarding the storage of linguistic experiences and the gradual nature of generalization. We argue that in addition to studying the long-term effects of distributional evidence in the input, the usage-based paradigm should take up related research in pragmatics and cognitive linguistics with a focus on the “online” properties of the situation. By putting interaction center-stage, we can study the development of children’s emerging conversational skills, but also draw on the full richness of the situation, which provides further cues to language learning.
Constructionist approaches to creativity
Authors: Hoffmann Thomas 
Published: November 2022

Abstract
Humans are an incredibly creative species – our minds have evolved to a degree that has enabled us to think original thoughts and come up with novel solutions to a great number of problems. One domain of human cognition that has recently received considerable attention is linguistic creativity. The present contribution will take a closer look at how Construction Grammar can account for various types of verbal creativity. In addition to this, it will also explore the implications of creative utterances for Construction Grammar as a mental theory of language.
Some identities on degenerate hyperharmonic numbers
Authors: Kim Taekyun , Kim Dae San 
Published: November 2022

Abstract
The aim of this paper is to investigate some properties, recurrence relations and identities involving degenerate hyperharmonic numbers, hyperharmonic numbers and degenerate harmonic numbers. In particular, we derive an explicit expression of the degenerate hyperharmonic numbers in terms of the degenerate harmonic numbers. This is a degenerate version of the corresponding identity representing the hyperharmonic numbers in terms of harmonic numbers due to Conway and Guy.
Resting heart rate variability as a diagnostic marker of cardiovascular dysautonomia in postural tachycardia syndrome
Authors: Inbaraj Ganagarajan , Udupa Kaviraja , Vasuki Prathyusha P. , Nalini Atchayaram , Sathyaprabha Talakad N. 
Published: November 2022

Abstract

Objectives
Postural orthostatic tachycardia syndrome (POTS) is a disorder of the autonomic nervous system characterised by orthostatic intolerance and orthostatic tachycardia without hypotension. Heart rate variability (HRV) is the most reliable and objective tool for assessing autonomic dysfunction severity. In the present study, we aimed to investigate HRV changes in resting supine position, predicting severity and cardiovascular risk in patients with POTS.

Methods
We compared 100 POTS patients with 160 healthy controls matched for age and gender in a case-control design. Along with clinical characterization, heart rate variability was evaluated using ambulatory 5 min ECG in lead II and expressed in frequency and time-domain measures.

Results
The resting heart rate of patients with POTS was significantly higher than that of healthy controls. In HRV measures, root mean square successive difference of RR intervals (RMSSD), total and high frequency (HF) powers were statistically lower with an increased low frequency (LF) to high-frequency ratio in patients with POTS compared to healthy controls. Further, stepwise logistic regression analysis showed increased basal HR and LF/HF as significant predictors of POTS and its severity.

Conclusions
This is the first study on a large cohort of patients with POTS from India wherein HRV was assessed. The study showed reduced parasympathetic activity and increased sympathetic activity in patients with POTS compared to healthy controls. These findings of increased resting heart rate and LF/HF were found to be potential predictors of POTS and future cardiovascular risks, which need to be replicated in a larger and more homogenized cohort.
The Long and Winding Road to Local Fiscal Equity in the United States: A Fifty-Year Retrospective
Authors: Martinez-Vazquez Jorge , Timofeev Andrey 
Published: November 2022

Abstract
Unlike many other countries, the United States does not have a comprehensive federal transfer scheme for explicit fiscal equalization but rather employs an array of categorical and block grants, some of which are formula-based while others are project-driven. However, the allocation of many of these grants has equalization effects resulting in the narrowing of fiscal disparities among jurisdictions. Few studies have attempted to quantify the extent of equalization achieved with federal and state grants in a manner that would allow comparisons across states and over time. In this study, we set out to measure the extent of equalization across local governments in the United States that is implicit in the federal grants system and more explicit in the grants implemented by the individual states. Rather than focusing on specific types of local services, we look at the evolution of per capita resources available to all types of local governments combined.
The Manchester Voices Accent Van: taking sociolinguistic data collection on the road
Authors: Drummond Rob , Dann Holly , Tasker Sarah , Ryan Sadie Durkacz 
Published: November 2022

Abstract
This article details the methodology behind the Manchester Voices Accent Van, and the accompanying online Virtual Van. In 2021, the project travelled around Greater Manchester in a van converted into a mobile recording booth, asking people to climb aboard and take part in an unsupervised interview about language and identity in the region. Participants could also take part from their own home through a bespoke website, called the Virtual Van, which asked the same interview questions as the physical Van and recorded speakers through their computer/phone microphone. With a view to informing others who might want to use similar methods in the future, we present a detailed description of the methodology here, as well as an overview and sample of the data collected. We conclude with a reflection on the elements of the data collection that went well, and a discussion of improvements and considerations for future research using this methodology.
Site-specific genome editing in treatment of inherited diseases: possibility, progress, and perspectives
Authors: Huang Chao , Li Qing , Li Jinsong 
Published: November 2022

Abstract
Advancements in genome editing enable permanent changes of DNA sequences in a site-specific manner, providing promising approaches for treating human genetic disorders caused by gene mutations. Recently, genome editing has been applied and achieved significant progress in treating inherited genetic disorders that remain incurable by conventional therapy. Here, we present a review of various programmable genome editing systems with their principles, advantages, and limitations. We introduce their recent applications for treating inherited diseases in the clinic, including sickle cell disease (SCD), β-thalassemia, Leber congenital amaurosis (LCA), heterozygous familial hypercholesterolemia (HeFH), etc. We also discuss the paradigm of ex vivo and in vivo editing and highlight the promise of somatic editing and the challenge of germline editing. Finally, we propose future directions in delivery, cutting, and repairing to improve the scope of clinical applications.