bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teachers' perceptions of the barriers to assessment of mental health in schools with implications for educational policy: A systematic review
Authors: O'Farrell Pia , Wilson Charlotte , Shiel Gerry 
Published: October 2022

AbstractBackgroundAssessment of mental health in schools has garnered increased interest in recent years. Children spend a large proportion of their waking hours in schools. Teachers can act as gatekeepers by playing a key role in identifying children with mental health difficulties in the classroom and making the necessary onward referrals to external services. The prevalence of mental health difficulties, their impact on schooling (and beyond) and the importance of early intervention means that it is incumbent on schools to identify and support potentially affected children.AimsPrevious reviews focused on mental healthinterventionsin schools; however, this review focuses onthe assessment ofmental health in schools and on teachers' perceptions of this, as such a review is still lacking. Therefore, the study fills a gap in the existing literature while also providing new, highly relevant evidence that may inform policy making in this area.Composition of studies included in this reviewThis review included 19 studies. Five studied teachers exclusively at primary/elementary level, and seven focused on secondary level, while six included both primary and secondary teachers. Three studies employed mixed methods, ten were primarily qualitative studies, and five were primarily quantitative.MethodsBronfenbrenner's (The ecology of human development: Experiments by nature and design, Harvard University Press, 1979) framework, adapted by Harvest (How can EPs best support secondary school staff to work effectively with children and young people who experience social, emotional and mental health difficulties?2018), which includes the mature version of the theory (Tudgeet al., 2009,J. Fam. Theory Rev., 1, 198), was used to analyse the literature.ResultsResults found that lack of training in assessment of mental health and ‘role conflict’ were key barriers; some teachers attributed this to their lack of knowledge, skills and confidence in the area.ConclusionImplications for practice and research are discussed in relation to the importance of sustained training both pre‐service and in‐service.
Two efficient selection methods for high‐dimensional CD‐CAT utilizing max‐marginals factor from MAP query and ensemble learning approach
Authors: Luo Fen , Wang Xiaoqing , Cai Yan , Tu Dongbo 
Published: October 2022

AbstractComputerized adaptive testing for cognitive diagnosis (CD‐CAT) needs to be efficient and responsive in real time to meet practical applications' requirements. For high‐dimensional data, the number of categories to be recognized in a test grows exponentially as the number of attributes increases, which can easily cause system reaction time to be too long such that it adversely affects the examinees and thus seriously impacts the measurement efficiency. More importantly, the long‐time CPU operations and memory usage of item selection in CD‐CAT due to intensive computation are impractical and cannot wholly meet practice needs. This paper proposed two new efficient selection strategies (HIA and CEL) for high‐dimensional CD‐CAT to address this issue by incorporating the max‐marginals from the maximum a posteriori query and integrating the ensemble learning approach into the previous efficient selection methods, respectively. The performance of the proposed selection method was compared with the conventional selection method using simulated and real item pools. The results showed that the proposed methods could significantly improve the measurement efficiency with about 1/2–1/200 of the conventional methods' computation time while retaining similar measurement accuracy. With increasing number of attributes and size of the item pool, the computation time advantage of the proposed methods becomes more significant.
Overtreatment of older people with type 2 diabetes—a high impact frequent occurrence in need of a new definition
Authors: Christiaens Antoine , Henrard Séverine , Boland Benoit , Sinclair Alan J. 
Published: October 2022

AbstractBackgroundDiabetes overtreatment is a frequent and major issue in older people with type 2 diabetes but its definition is often inconsistent and may be misleading. This critical review has aimed at examining the definitions of diabetes overtreatment in older people used in research studies.MethodsStudies addressing diabetes overtreatment in people aged 65 or older were identified by searching the PubMed database according to an extensive search equation.ResultsTwenty‐two research studies providing a definition of diabetes overtreatment in people aged were found. Overall, 12 different definitions of diabetes overtreatment were used. All studies defined overtreatment according to a HbA1c threshold (varying from <42 mmol/mol [<6.0%] to <64 mmol/mol [<8%]). Amongst them, 2 definitions had no consideration about glucose‐lowering (GL) treatment, 6 required the prescribing of ≥1 GL agent(s), and 4 the prescribing of ≥1 GL agent(s) inducing the high risk of hypoglycaemia (i.e., sulfonylurea(s) or insulin(s)). Only 4 definitions (four studies) were individualised, using varying HbA1c thresholds according to patients' age or health status.ConclusionsDefinitions of diabetes overtreatment are heterogeneous across research studies, which is confusing. A standardised definition, based on the individual risk of hypoglycaemia and/or its complications must be promoted in order to bring clarity and greater insight into this field, as well as to improve the quality of management of diabetes in older patients.
Toward an understanding of the implementation of management innovation in international joint ventures: A multilevel perspective
Authors: Bahri Korbi Fadia , Geraudel Mickael , Nakara Walid A. 
Published: October 2022

AbstractImplementing management innovation (MI) is a great challenge for international joint ventures (IJVs), specifically for those between multinational enterprises (MNEs) and local firms. Different multilevel factors have been shown in the international business literature to play a role in MI implementation within IJVs. In this paper, we add to this literature by showing that these factors do not act in isolation and that their interplay must be considered. To this aim, we draw on qualitative data from 35 CEOs and TMT members of five IJVs between European MNEs and Tunisian local firms. Overall, our study reveals that depending on the type of IJV, the multilevel factors playing a role in the implementation of MI are different.
BAP1 depletion in human B‐lymphoblast cells affects the production of innate immune cytokines and chemokines
Authors: Takagi‐Kimura Misato , Tada Akio , Kijima Takashi , Kubo Shuji , Ohmuraya Masaki , Yoshikawa Yoshie 
Published: October 2022

AbstractBRCA1 associated protein 1 (BAP1) is a ubiquitin C‐terminal hydrolase that deubiquitinates histone H2AK119ub and other proteins and regulates the expression of multiple genes. The knockout of this tumor suppressor gene results in severe thymic atrophy, complete loss of the T cell lineage, and abnormal B cell development in mice. In the current study, we investigated in vitro effects of BAP1 knockout on cytokine and chemokine production using the human B‐lymphoblast cell line TSCE5. We confirmed that knockout changed the production of innate immune‐associated genes and their receptors. The CCL19, CCR7, CCL2, and CXCR5 genes associated with T and B cell migration were upregulated. Knockout cells producing high levels of CCL19 showed acceleration of actin polymerization, which is essential for cell migration. CD69, PTPRC, and TLR3 genes that activate inflammation were downregulated. The tumor necrosis factor ligand genes TNF, LTA, and TNFSF10 were downregulated by knockout. In knockout cells, TNFα production was strongly downregulated upon the addition of H2O2, but NF‐κB in the basal condition and when TNFα was added was augmented, suggesting that these cells could respond to TNFα. These results indicated that BAP1 affects the expression of chemokines and cytokines, T and B cell migration, and activated inflammation associating with innate immunity.
Early‐phase prothrombin time‐international normalized ratio in acute liver injury indicates the timing of therapeutic intervention and predicts prognostic improvement
Authors: Kumagai Kotaro , Mawatari Seiichi , Moriuchi Akihiro , Oda Kohei , Takikawa Yasuhiro , Kato Naoya , Oda Shigeto , Inoue Kazuaki , Terai Shuji , Genda Takuya , Shimizu Masahito , Sakaida Isao , Mochida Satoshi , Ido Akio 
Published: October 2022

AbstractAimWe investigated whether an early‐phase prothrombin time‐international normalized ratio (PT‐INR) is an interventional prognostic indicator for patients with acute liver injury, including acute liver failure.MethodsThis was a multicenter retrospective observational study. We included 595 patients with alanine aminotransferase levels ≥300 U/L due to acute liver injury who were admitted to Kagoshima University Hospital or other collaborative investigation organizations between January 1, 2010, and December 31, 2015. Patients with alanine aminotransferase levels ≥300 U/L and no previous liver disease were defined as having an acute liver injury. Acute liver failure was defined by PT‐INR ≥1.5 with or without hepatic encephalopathy in acute liver injury patients. Data were obtained retrospectively from case reports and analyzed.ResultsThe PT‐INR on day 1 was the most accurate independent prognosis predictor in patients with acute liver injury and acute liver failure. On day 1, the transplant‐free survival rates were significantly lower in patients with PT‐INR ≥1.3. The transplant‐free survival rates were also significantly higher in patients with acute liver injury and acute liver failure, in whom the PT‐INR had recovered from ≥1.3 on day 1 to <1.3 by day 8.ConclusionEarly‐phase changes in the PT‐INR can predict the prognosis of patients with acute liver injury and acute liver failure. Furthermore, PT‐INR ≥1.3 could be an interventional marker, whereas PT‐INR <1.3 after 1 week could reflect prognostic improvement.
Towards a functional classification of poorly known tropical insects: The case of rhinoceros beetles (Coleoptera, Dynastinae) in Panama
Authors: Basset Yves , Blažek Petr , Souto‐Vilarós Daniel , Vargas Gersey , Ramírez Silva José Alejandro , Barrios Héctor , Perez Filonila , Bobadilla Ricardo , Lopez Yacksecari , Ctvrtecka Richard , Šípek Petr , Solís Angel , Segar Simon T. , Lamarre Greg P. A. 
Published: October 2022

AbstractThe population dynamics of most tropical insects are unknown and long‐term monitoring programmes are urgently needed to evaluate a possible insect decline in the tropics. In this context, functional groups can be used effectively to summarise time‐series for species‐rich taxa. Neotropical dung beetles have often been catalogued into functional groups, but close relatives also of ecological significance, the Dynastinae, are awaiting such a classification.Here, we examine the functional groups of Dynastinae at the regional (Panama: 147 species) and local (Barro Colorado Island, BCI: 56 species) scales. Our optimum classification of Panamanian species distinguished five groups, one of which is probably artificial and accounts for species ecologically poorly known.Ecological attributes or species traits mainly influencing the delineation of groups were geographical distribution, body length, seasonal aggregation, larval food and whether the adult may be present in decaying wood.Our analyses indicated that (1) missing trait values and the high percentage of ‘cryptic’ species (25%) influenced the delineation of groups; (2) the dendrogram similarity of functional groups versus phylogenetic tree was low, although some traits were phylogenetically conserved; and (3) the overall structure of functional groups was conserved when comparing regional and local data, suggesting no drastic loss of functional groups locally.To proceed with the functional classification of poorly known tropical insects, we recommend a cautious selection of traits a priori, inclusion of ‘cryptic’ species recognised by DNA barcoding, and building phylogenies, which may allow a careful taxonomic imputation to complete species‐traits matrices.
Antiplaque and antigingivitis efficacy of new and worn manual toothbrushes: A systematic review and meta‐analysis
Authors: Silva Francisco Hecktheuer , Montagner Anelise Fernandes , Silveira Mateus Costa , Muniz Francisco Wilker Mustafa Gomes 
Published: October 2022

AbstractObjectiveTo systematically review the literature about the antiplaque and antigingivitis efficacy of new and worn manual toothbrushes.MethodsFive databases were searched to identify randomized controlled trials, involving adults, comparing the clinical efficacy of new and worn manual toothbrushes. Experimental groups need to have different usage time in changing their manual toothbrush. Two reviewers performed studies selection, data extraction and risk of bias assessment independently. Meta‐analyses were performed comparing the toothbrushes after a single use (antiplaque efficacy) and after multiple uses (antiplaque and antigingivitis efficacy).ResultsEight studies were included, totalling 344 individuals. In studies with a single‐use design, no statistically difference was found between new and worn toothbrushes for antiplaque efficacy (SMD:‐0.39; 95%CI:−0.80 to 0.03). Studies with a multiple‐use design showed no statistically difference between groups for the antigingivitis efficacy (MD:−0.10; 95%CI:−0.24 to 0.03). However, higher antiplaque efficacy was demonstrated in new toothbrushes in the studies with a multiple‐use design (SMD:−0.75; 95%CI:−1.37 to −0.14). The certainty of the evidence ranged from very low (antiplaque) to low (antigingivitis).ConclusionNew and worn toothbrushes presented similar antiplaque and antigingivitis efficacy. However, further randomized controlled trials, with a lower risk of bias, are needed to enhance the certainty of this evidence.
Impacts of natural antioxidants on the fatty acid profiles of vacuum‐packaged tuna‐like muscles
Authors: Lahreche Talal , Ozogul Fatih , Ucar Yilmaz , Ameur Abderrahmane 
Published: October 2022

SummaryThe impacts of natural preservatives such as olive leaf (Olea europaea L.) and sweet marjoram (Origanum majorana L.) extracts (OLE and SME) and cold storage on the fatty acid profiles of vacuum‐packaged tuna‐like muscles were evaluated. At the end of the storage time, the lowest content of the total saturated fatty acids (SFA) was observed in both ordinary and dark muscles of the treated samples (OLE and SME) whereas the highest content was found in their counterparts from the untreated samples (control). The total polyunsaturated fatty acid (PUFA) and total monounsaturated fatty acid (MUFA) contents decreased markedly in both ordinary and dark muscles of the control samples. In contrast, treated samples remained relatively stable throughout the storage time since the employment of plant extracts had protective effects against lipid oxidation and help maintain MUFA and PUFA levels in frigate tuna muscles. In addition, the PUFA/SFA ratio and polyene index which are considered important dietetic parameters showed that the used plant extracts (OLE and SME) did not result in a reduction in the PUFA/SFA ratio and prevented PUFA damage in both frigate tuna muscles during storage. Thus, the use of plant extracts such as OLE and SME can be recommended as natural preservatives for the fish processing industry.
The digitally mediated lives of women MSME entrepreneurs in India: Navigating the “access‐use” conundrum
Authors: Mishra Anindya Jayanta , Mohanty Elisa 
Published: October 2022

AbstractThe dialectics of information and communication technologies (ICTs) entail their potential in fostering digital dividends and fomenting digital exclusion. Based on 165 personal interviews with women entrepreneurs of MSMEs in the Ganjam and Gajapati districts of the state of Odisha in India, this study considers the opportunities and challenges regarding the access and use of ICTs. The primary intent of the study is to explore the participants’ views on the diversity of ICT use, the relevance of these technologies for their businesses, and the challenges they face while using the digital technologies. Deploying Amartya Sen's Capability Approach (CA) as the primary theoretical lens, this study documents the popularity of “new ICTs” among the respondents, the constraints they face in performing digital transactions, their views on digital exclusion, and the impact of local factors (language barriers and institutional support) on their digital appropriation. Based on these findings, the study emphasises the need for increased availability of business‐relevant content on ICT platforms, incorporation of ICT training in ongoing programmes, and explores ways of overcoming the language barriers and promoting effective use of digital payment applications. This study aims at enhancing the ICT‐related capability sets of women entrepreneurs in the underdeveloped sub‐regions of India.
The adaptive ability performance test (ADAPT): A factor analytic study in clients with intellectual disabilities
Authors: Jonker Femke , de Looff Peter , van Erp Sara , Nijman Henk , Didden Robert 
Published: October 2022

AbstractBackgroundThe adaptive ability performance test (ADAPT) was developed to assess adaptive skills in individuals with intellectual disabilities and borderline intellectual functioning, with or without mental disorders. As a follow‐up to earlier research on the ADAPT, a factor analytic study was conducted.MethodOne thousand and sixty six ADAPTs from clients with (suspected) intellectual disabilities or borderline intellectual functioning and 129 ADAPTs from participants from the general population were collected along with other characteristics (e.g., IQ, psychiatric classifications, living situation).ResultsAn exploratory factor analysis (EFA) was performed and resulted in good fit indices. Subsequent confirmatory factor analysis (CFA) and multigroup CFA showed acceptable to good fit indices. This resulted in an instrument with eight factors and 62 items.ConclusionFactor analytic results suggest that the ADAPT is a valid instrument that measures adaptive skills in individuals with intellectual disabilities or borderline intellectual functioning.
Seeking Legitimacy Through Knowledge Production: The Politics of Monitoring and Evaluation of the EU Trust Fund for Africa
Authors: Welfens Natalie , Bonjour Saskia 
Published: October 2022

AbstractMonitoring and evaluation (M&E) is a form of expert knowledge that is central to migration governance. This article analyses M&E of the EU Trust Fund for Africa (EUTF), created in 2015 to ‘fight the root causes of migration’. Combining institutionalist accounts with practice theory, we examine whether M&E knowledge production served the instrumental purpose of assessing policy impact or mainly legitimated particular policy actors and positions. We find that M&E did not produce evidence on whether the EUTF met its objectives. However, in the context of the EU's multiple crises, M&E knowledge production served to seek legitimacy not only for the EUTF, but also for the further fusion of development and migration policies, and for the EU as a competent and transparent actor. Our analysis highlights that knowledge use and knowledge production are connected, and that M&E knowledge politics allow for the legitimation of both actors and policies.
Clinical signs of type 1 diabetes are associated with type 2 diabetes marker transcription factor 7‐like 2 polymorphism
Authors: Ergür Efe , Ergür Ege , Alnek Kristi , Metsküla Kaja , Peet Aleksandr , Lubi Maire , Heilman Kaire , Uibo Raivo 
Published: October 2022

AbstractAims/IntroductionWe aimed to assess the distribution of transcription factor 7‐like 2 gene TCF7L2 (rs7903146) polymorphism and to find possible associations between TCF7L2 and the characteristics of type 1 diabetes.Materials and MethodsWe studied 190 newly diagnosed type 1 diabetes patients (median age 12.7 years, range 2.0–72.5) and 246 controls (median age 23.8 years, range 1.4–81.5) for TCF7L2 single nucleotide polymorphism. We determined anti‐islet autoantibodies, random C‐peptide levels, diabetes associated HLA DR/DQ haplotypes and genotypes in all patients.ResultsThere were no differences in the distribution of TCF7L2 single nucleotide polymorphism between patients and controls. However, patients with in type 1 diabetes, after adjusting for age and sex, subjects carrying C allele were at risk for a C‐peptide level lower than 0.5 nmol/L (OR 5.65 [95% CI: 1.14–27.92]) and for zinc transporter 8 autoantibody positivity (5.22 [1.34–20.24]). Participants without T allele were associated with a higher level of islet antigen‐2 autoantibodies (3.51 [1.49–8.27]) and zinc transporter 8 autoantibodies (2.39 [1.14–4.99]).ConclusionsThe connection of TCF7L2 polymorphism with zinc transporter 8 and islet antigen‐2 autoantibodies and C‐peptide levels in patients supports the viewpoint that TCF7L2 is associated with the clinical signs and autoimmune characteristics of type 1 diabetes. The mechanisms of the interaction between the TCF7L2 risk genotype and anti‐islet autoantibodies need to be studied further.
Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis)
Authors: Li Xiantang , Santos Rosemary , Bernal Jan E. , Li Dingzhou D. , Hargaden Maureen , Khan Nasir K. 
Published: October 2022

AbstractBackgroundThe cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades.MethodsThis review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.ResultsThe cynomolgus macaque is born precocious relative to humans in some organ systems (e.g., nervous, skeletal, respiratory, and gastrointestinal). Organ systems develop, refine, and expand at different rates after birth. In general, the respiratory, gastrointestinal, renal, and hematopoietic systems mature at approximately 3 years of age. The female reproductive, cardiovascular and hepatobiliary systems mature at approximately 4 years of age. The central nervous, skeletal, immune, male reproductive, and endocrine systems complete their development at approximately 5 to 9 years of age.ConclusionsThe cynomolgus macaque has no meaningful developmental differences in critical organ systems between 2 and 3 years of age for use in nonclinical safety assessment.