bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to Pediatric Eye Care Following Vision Screening
Authors: Chung Michael , Robinson Ben , Fukuda Matthew , Dunbar Jennifer A. , Ulangca Richard A. , Khazaeni Leila M. 
Published: March 2022

Purpose:
To quantify the accessibility of eye care providers from photoscreening centers within the vision screening region in relation to population density and median household income.

Methods:
Driving times between vision screening locations and eye care centers were mapped and analyzed using OpenStreetMap software (Open Street Map Foundation). U.S. Census Bureau data of population density and median household income were linked with screening centers using ArcGIS Online (Esri) to determine correlations with driving times.

Results:
A total of 290 driving times for 145 photo-screening centers, 147 optometrists, and 7 pediatric ophthalmologists were calculated and mapped. Median driving times from a photoscreening center to the nearest optometrist and ophthalmologist were 4.74 and 25.10 minutes, respectively, with 90% of the screening centers residing within 12.46 and 67.19 minutes of the nearest optometrist and ophthalmologist, respectively. Driving times to optometrists are far less than times to pediatric ophthalmologists due to the greater number of optometrists. Decreasing driving times with increasing population and median household income indicate the concentration of optometrists and pediatric ophthalmologists within urbanized areas.

Conclusions:
Most photoscreening centers reside within 5 and 70 minutes of the nearest optometrist and pediatric ophthalmologist, respectively. Driving times indicate the region's greater accessibility to optometrists than to pediatric ophthalmologists. Eye care centers tend to be localized within urbanized areas with higher population densities and higher median household incomes.

[
J Pediatr Ophthalmol Strabismus
. 2022;59(6):369–374.]
Outcomes of a Simple Lateral Rectus Belly Transposition Procedure Combined With Ipsilateral Antagonist Recession for Vertical Rectus Palsy
Authors: Xia Weiyi , Ling Ling , Wen Wen , Jiang Chao , Wang Xiying , Wu Lianqun , Sun Xiantao , Yao Jing , Zhao Chen 
Published: March 2022

Purpose:
To report the surgical effects of a combination treatment comprising the lateral rectus belly transposition (LRBT) procedure, without muscle splitting or disinsertion, and ipsilateral antagonist recession for vertical rectus palsy.

Methods:
The medical records of consecutive patients who underwent the LRBT procedure between 2017 and 2020 were reviewed. Preoperative and postoperative deviation in primary position, preoperative and postoperative scale of duction of the palsied muscle, any induced horizontal or torsional deviation, and other complications were collected.

Results:

Thirteen patients were identified: 10 with inferior rectus palsy and 3 with superior rectus palsy. The mean postoperative follow-up time was 20.4 ± 8.0 months. Eleven patients (84.6%) underwent simultaneous recession of the ipsilateral antagonist muscle of the palsied vertical rectus. After surgery, the mean vertical deviation improved from 31.4 ± 16.4 to 1.9 ± 3.6 prism diopters (PD) (
P
< .001). The mean vertical duction limitation of the palsied muscle improved from −2.7 ± 0.6 to −0.6 ± 0.5 (
P
= .001). In one patient, the scleral fixation suture was removed due to continuous reverse vertical diplopia. The total success rate was 76.9%. No induced horizontal deviation was noted. Anterior segment ischemia or other severe surgical complications did not occur.

Conclusions:
The LRBT procedure can be effective, safe, and reversible in patients with vertical rectus palsy. It allows for the option of simultaneous ipsilateral antagonist recession, and it is especially valuable in patients whose vertical duction deficiency is worse in abduction but mild in adduction.

[
J Pediatr Ophthalmol Strabismus
. 2022;59(6):396–404.]
Comparison of Optical Zone Decentration Following FS-LIKE and SMI-LIKE for Correcting Hyperopia
Authors: Liu Shengtao , Zhang Xiaoxue , Yu Lanhui , Li Meiyan , Zhou Xingtao 
Published: March 2022

PURPOSE:
To investigate optical zone decentration following femtosecond laser–assisted lenticule intrastromal keratoplasty (FS-LIKE) or small incision lenticule intrastromal keratoplasty (SMI-LIKE) for correcting hyperopia.

METHODS:
This study analyzed decentration values obtained from optical coherence tomography (OCT) and tangential topography difference maps of 23 eyes (18 patients) undergoing FS-LIKE (n = 12) or SMI-LIKE (n = 11) via the concentric centration method. Total higher order aberrations (HOAs) and component aberrations were measured preoperatively and 6 months postoperatively.

RESULTS:

The mean optical zone decentration was 0.27 ± 0.08 and 0.39 ± 0.16 mm for the FS-LIKE and SMI-LIKE groups, respectively (
P
= .039). A significant difference was noted in lenticule decentration between the two groups (0.18 vs 0.37 mm), whereas no significant difference was observed in stromal bed (pocket) decentration between the two groups (0.10 vs 0.12 mm). Six months after surgery, the spherical equivalent showed a reduction of 6.14 ± 2.44 and 6.10 ± 1.79 diopters (D) for the two groups, respectively (
P
= .971), whereas the surgically induced astigmatism was 0.68 ± 0.49 and 1.56 ± 0.78 D for the two groups, respectively (
P
= .004). Furthermore, induction of HOAs in the SMI-LIKE group was significantly larger than that in the FS-LIKE group (
P
= .013).

CONCLUSIONS:
FS-LIKE can yield improved treatment centration and less induction of total HOAs.

[
J Refract Surg
. 2022;38(3):184–190.]
Extended Depth of Focus Versus Monofocal IOLs in Patients With High Myopia: Objective and Subjective Visual Outcomes
Authors: Pedrotti Emilio , Neri Enrico , Bonacci Erika , Barosco Guido , Galzignato Alice , Montresor Andrea , Rodella Anna , De Gregorio Alessandra , Bosello Francesca , Marchini Giorgio 
Published: March 2022

PURPOSE:
To compare the objective and subjective outcomes between the extended depth of focus (EDOF) Mini Well intraocular lens (IOL) and the aspheric monofocal Mini-4-Ready IOL (both SIFI S.p.A.) in patients with high myopia.

METHODS:
In this prospective comparative study, 40 patients with high myopia (axial length ≥ 26 mm) were enrolled: 20 patients were bilaterally implanted with the EDOF Mini Well IOL (EDOF group) and 20 patients were bilaterally implanted with the Mini-4-Ready IOL (monofocal group). Three-month follow-up data included corrected and uncorrected distance visual acuity at 4 m and 80, 67, and 40 cm, defocus curves, subjective and objective contrast sensitivity, objective optical quality (calculated with Optical Quality Analysis System; Visiometrics SL), halometry, and reading performance. Subjective visual quality was evaluated with National Eye Institute Refractive Error Quality of Life Instrument 42 scores.

RESULTS:

All visual acuities were significantly better in the EDOF group (
P
⩽ .04) except monocular and binocular uncorrected and corrected distance visual acuities for distance (
P
≥ .50). Defocus curves for myopic and hyperopic values were better in the EDOF group (
P
⩽ .05), apart from +0.50 to −0.50 D (
P
≥ .16). Contrast sensitivity curves was worse in the EDOF group in the mesopic-with-glare condition (
P
⩽ .04). No differences were found in halometric values (
P
≥ .15) and OQAS outcomes (
P
≥ .47). National Eye Institute Refractive Error Quality of Life Instrument 42 subscale scores were better for expectation, near vision, activity limitations, and dependence on correction in the EDOF group (
P
⩽ .04).

CONCLUSIONS:
Intermediate and near visual acuities were better in the EDOF group than in the monofocal group, with a comparable visual quality index between groups.

[
J Refract Surg
. 2022;38(3):158–166.]
The Quantification and Impact of Persistent Retinal Fluid Compartments on Best-Corrected Visual Acuity of Patients With Retinal Vein Occlusion
Authors: Muste Justin C. , Iyer Amogh I. , Kalur Aneesha , Talcott Katherine E. , Singh Rishi P. 
Published: March 2022

BACKGROUND AND OBJECTIVES:
To evaluate the impact of persistent intraretinal fluid (IRF) and subretinal fluid (SRF) on best visual acuity (BVA) of patients with retinal vein occlusions (RVOs).

PATIENTS AND METHODS:
This retrospective cohort study observed 92 treatment-naïve patients with RVO during 12 months of treatment with anti–vascular endothelial growth factor agents. Deep learning was used to quantify IRF and SRF volumes, and linear mixed effects regression modeled the impact on BVA.

RESULTS:

Average IRF volume declined −923.1 ± 2,382.5 nL from baseline to 12 months (
P
< .001). Average SRF volume declined −35.4 ± 223.4 nL from baseline to 12 months (
P
= .139). linear mixed effects regression modeling disclosed IRF≥ 1,616 nL at all time points predicted a −10.38 letter loss at 12 months (95% CI, −14.58 to −5.9 letters;
P
< .001). A similar relationship was not found for SRF.

CONCLUSION:
Persistent IRF may be an important prognostic biomarker for BVA outcomes in real-world patients with RVO.

[
Ophthalmic Surg Lasers Imaging Retina
. 2022;53:139–147.]
La sociologie des sociologues
Authors: Piriou Odile 
Published: March 2022

Depuis 30 ans, la sociologie a connu des bouleversements radicaux : création d’un cursus d’enseignement universitaire, de revues, de laboratoires et d’associations ; constitution d’un corps d’experts et diversification des débouchés professionnels. En bien des domaines, la sociologie s’est donc professionnalisée à l’instar d’autres disciplines. Mais ce processus a suivi une tendance bien précise : la sociologie est devenue une profession en misant essentiellement sur son « segment » académique. Elle a organisé et valorisé les activités de sociologie en se conformant au modèle de la science. La formule scientifique, pour laquelle la sociologie a opté, pose de multiples questions quant à ses conséquences sur la formation, la définition du métier, l’accès à l’emploi et au titre universitaire. Comment se définit le sociologue de cette fin de siècle en France ? Quels sont les processus qui le conduisent à affirmer une identité à la croisée des chemins entre science et pratique ? Comment cette identité s’affirme-t-elle à travers la diversité des cursus universitaires et professionnels ? Et au-delà, quels rapports les diplômés entretiennent-ils avec leur formation ? Voici quelques-unes des questions auxquelles répondra cet ouvrage qui repose sur une enquête menée auprès d’une cohorte de diplômés. En situant ses propos théoriques dans le contexte renouvelé de la sociologie des professions américaine, l’auteur livre un travail d’enquête et de réflexion qui contribue à la connaissance sociologique de la sociologie. Un objet d’étude étrangement peu exploré jusqu’alors.
La politique islandaise piratée ?
Authors: Cordier Lionel 
Published: March 2022

Depuis 2008, l’Islande a été le théâtre de plusieurs crises politiques majeures. Suite à la crise économique et à la démission du gouvernement, des élections anticipées ont placé pour la première fois dans l’histoire du pays une coalition de gauche au pouvoir en avril 2009. Plus récemment, au printemps 2016, les scandales des « Panama Papers » ont fortement touché la classe politique islandaise et le gouvernement formé par le Parti du progrès et le Parti de l’indépendance, entre-temps revenus aux affaires en 2013. Mais ces évènements sont les symptômes de changements bien plus profonds dans la vie politique islandaise, que l’émergence du Parti pirate islandais permet de mieux éclairer. Né trois ans après la « révolution des casseroles », ce parti bénéficie toujours d’une grande popularité et a obtenu un nombre de sièges important aux dernières élections parlementaires d’octobre 2016, bien que pas autant qu’il était anticipé. En couplant un discours à vocation internationale sur les enjeux du Web et de la transparence à un discours sur les défis socioéconomiques de l’Islande, le parti semble avoir attiré de larges franges de l’électorat jeune et populaire. Il bénéficie également des spécificités sociales et politiques de l’île, moins touchée par la montée des droites radicales que le reste de l’Europe du Nord.
Le livre XI des Métamorphoses d’Apulée ou du platonisme aux Oracles chaldaïques
Authors: Bakhouche Béatrice 
Published: March 2022

Le dernier livre des Métamorphoses d’Apulée pose maints problèmes d’interprétation : quel lien ces dernières pages, d’une tout autre tonalité que le reste du roman, entretiennent-elles avec ce qui précède et avec les textes – philosophiques – de l’auteur ? quelle lecture donner des rites isiaques ? des trois initiations successives ? C’est à ces questions que nous chercherons à répondre en convoquant l’héritage platonicien mais aussi les Oracles Chaldaïques.The last book of Apuleius’ Metamorphoses raises many interpretation problems: what link do these last pages, of a completely different tone from the rest of the novel, have with the preceding parts and with the author’s – philosophical – texts ? What reading should be given to the isiatic rites and the three successive initiations? These are the questions that we will try to answer by invoking the Platonic heritage but also the Chaldaean Oracles.
Chlorzoxazone Alleviates Experimental Autoimmune Encephalomyelitis via Inhibiting IL-6 Secretion of Dendritic Cells
Authors: Lv Jie , Han Mengyao , Xiang Zhenglong , Gong Ran , Shi Changjie , Hua Qiuhong , Zhang Ru , Du Changsheng 
Published: March 2022

Abstract
Multiple sclerosis (MS) is a chronic inflammatory demyelinating autoimmune disease with chronic inflammatory demyelination of the CNS. Experimental autoimmune encephalomyelitis (EAE) is an important animal model to study MS, with many pathological phenomena similar to MS. Th17 cells are important regulators of EAE and MS pathogenesis. Most cytokines needed for Th cell development are secreted by APCs, such as dendritic cells (DCs). Consequently, MS could be improved by inhibiting cytokine secretion from DCs. In this study, we reported that chlorzoxazone could ameliorate EAE pathogenesis via inhibiting IL-6 production by DCs. The EAE signs in the chlorzoxazone-treated group of mice were relieved, which was mainly manifested as lower clinical scores, a decrease in the number of immune cells, and a reduction of demyelination in the CNS. Moreover, the proportion of Th17 cells in the spleen and CNS decreased significantly. In vitro experiments showed that chlorzoxazone treatment significantly reduced DC-derived IL-6 production. In the DC–T cell coculture experiment, significantly decreased Th17 differentiation was observed after chlorzoxazone treatment. In addition, mass spectrometric analysis was performed to elucidate the mechanism by which chlorzoxazone affected EAE and DC function. We showed that the effect of chlorzoxazone on inhibiting the secretion of IL-6 by DCs may be mediated via the AMP-activated protein kinase pathway. Overall, our study elucidated the key role of chlorzoxazone in regulating EAE pathogenesis and suggested that it might be used as a new drug for MS patients.
Activated Platelets Upregulate β2 Integrin Mac-1 (CD11b/CD18) on Dendritic Cells, Which Mediates Heterotypic Cell–Cell Interaction
Authors: Nording Henry , Sauter Manuela , Lin Chaolan , Steubing Rebecca , Geisler Sven , Sun Ying , Niethammer Joel , Emschermann Fréderic , Wang Yunmei , Zieger Barbara , Nieswandt Bernhard , Kleinschnitz Christoph , Simon Daniel I , Langer Harald F 
Published: March 2022

Abstract
Recent evidence suggests interaction of platelets with dendritic cells (DCs), while the molecular mechanisms mediating this heterotypic cell cross-talk are largely unknown. We evaluated the role of integrin Mac-1 (αMβ2, CD11b/CD18) on DCs as a counterreceptor for platelet glycoprotein (GP) Ibα. In a dynamic coincubation model, we observed interaction of human platelets with monocyte-derived DCs, but also that platelet activation induced a sharp increase in heterotypic cell binding. Inhibition of CD11b or GPIbα led to significant reduction of DC adhesion to platelets in vitro independent of GPIIbIIIa, which we confirmed using platelets from Glanzmann thrombasthenia patients and transgenic mouse lines on C57BL/6 background (GPIbα−/−, IL4R-GPIbα-tg, and muMac1 mice). In vivo, inhibition or genetic deletion of CD11b and GPIbα induced a significant reduction of platelet-mediated DC adhesion to the injured arterial wall. Interestingly, only intravascular antiCD11b inhibited DC recruitment, suggesting a dynamic DC–platelet interaction. Indeed, we could show that activated platelets induced CD11b upregulation on Mg2+-preactivated DCs, which was related to protein kinase B (Akt) and dependent on P-selectin and P-selectin glycoprotein ligand 1. Importantly, specific pharmacological targeting of the GPIbα–Mac-1 interaction site blocked DC–platelet interaction in vitro and in vivo. These results demonstrate that cross-talk of platelets with DCs is mediated by GPIbα and Mac-1, which is upregulated on DCs by activated platelets in a P-selectin glycoprotein ligand 1–dependent manner.
A Self-Assessment Model for Hospital Safety Culture Maturity
Authors: Liana Duta , Lestari Fatma , Sutoto Sutoto , Modjo Robiana , Bachtiar Adang 
Published: March 2022

Background Studies on safety culture maturity in health care is very rare, and the existing ones only focus on patients and the use of Manchester Patients Safety Framework (MaPSaF) instrument. The objective of this study is to develop a comprehensive instrument for measuring safety culture maturity in hospitals. Design and methods This study used a cross-sectional design with three stages. First, we used secondary data analysis from the Hospital Accreditation Commission. Second, evaluation of primary data obtained from safety climate questionnaire. Third, we did focus group discussions, and in-depth interviews for validation of secondary data and development of DUTA-RS website. We analyzed using Structural Equation Modeling (SEM) test. Results DUTA-RS instrument contains 1,118 elements based on the first edition of the Indonesian Hospital Accreditation National Standard. Its safety culture maturity is at the proactive level (58.0%), with the highest accreditation levels of proactive (50.8%) and generative (48.7%). The variables affecting the safety culture maturity are situational and safety behavior variables, with leadership, risk management, and safety compliance as the strongest indicators. The weakest indicators of climate are organizational learning and communication. The mean value of climate for primary and secondary data is in the good category and showed in proactive level. Conclusions The DUTA-RS as a website to measure the safety culture maturity in accredited hospitals by taking the advantage of the existing information technology of hospital accreditation committee as the benchmark enables improvement of SCML in hospitals. Further studies are required for the development of DUTA-RS website.
Exploring Best Practices in Preceptorships: Preceptor Selection
Authors: Rager Huett Jessica L. , Wessel Roger D. 
Published: March 2022

Context
Athletic training programs have autonomy to select preceptors based on program objectives. Due to a lack of empirical evidence outlining best practices for graduate programs, program administrators must appraise this themselves. Gaining information on what stakeholders believe is most appropriate when considering clinicians for the role of preceptor may help administrators choose preceptors who are well suited to teach.

Objective
The purpose of this study was to explore stakeholders (ie, preceptors, program directors, clinical education coordinators) beliefs of the ideal qualities of athletic training preceptors.

Design
Hermeneutic phenomenological approach.

Setting
Individual phone interviews.

Patients or Other Participants
Nineteen individuals (10 clinical education coordinators, 7 preceptors, 1 program director, 1 dual-role program administrator; 7.74 ± 6.30 years of experience). Data saturation guided the total number of participants.

Data Collection and Analysis
A semistructured interview guide was used to conduct interviews, which were recorded and transcribed verbatim. Data were analyzed by the primary investigator and coded into themes using the interpretative phenomenological analysis approach. Peer reviews and narrative-accuracy member checks established credibility.

Results
Participants discussed their desire for preceptors to prioritize their role as educator by being committed to teaching and creating abundant experiences for learners. In addition, participants described ideal preceptors as those who practice with professionalism by setting a good example, meeting administrative expectations, and having autonomous experiences beyond their professional degree. Finally, participants discussed preceptors should have the qualities of leaders by possessing a growth mindset, utilizing best practices as they relate to recent literature and evolving clinical skills, and embracing educational advancement.

Conclusions
To promote the best learning environment, preceptors should possess the qualities of an educator, professional, and leader. The findings of this study help inform decisions regarding who may be best suited to serve as preceptor. Future research should investigate what stakeholders believe are ideal components of preceptor development.
Neurological Manifestations and Mortality in Hospitalized Coronavirus Disease 2019 Patients
Authors: Özel Tugba , Erdem Nazan Şimşek , Ünal Ali , Yalçın Ata Nevzat , İnan Dilara , Ilhanli Nevruz , Uysal Hilmi 
Published: March 2022

Purpose:
The purpose of the study is to analyze the neurological manifestations and to determine the association between these symptoms and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19).

Materials and Methods:
Five hundred and forty-seven hospitalized patients with positive reverse transcriptase-polymerase chain reaction tests for severe acute respiratory syndrome coronavirus in a nasopharyngeal swab were included in this study. The demographic features, laboratory data, and radiologic imaging, neurological symptoms of hospitalized patients with COVID-19 were collected.

Results:
Of 547 hospitalized COVID-19 patients, the median age was 61 (range 18–93), 61.4% were male. Three hundred and forty-seven (63.4%) patients had a severe infection and 200 (36.6%) patients had a mild infection. Eighty-eight patients (16.1%) died during hospitalization. One hundred and fifty-four (28.2%) patients had at least one neurological symptom. Thirty-five (6.4%) patients manifested with only neurological symptoms at hospital admission. The most frequent neurological symptoms were headache (15.2%), taste and smell disorders (9.1%), and myalgia (6.6%). The other initial neurological manifestations were acute cerebral ischemic stroke, impaired consciousness, epileptic seizure, and posterior reversible encephalopathy. The late-onset neurological complications were autoimmune encephalitis and Guillain-Barre syndrome. The neurological manifestation was linked to the severity of disease (P = 0.005) but not correlated with mortality (P = 0.137).

Conclusion:
Neurological symptoms were frequent in COVID-19 patients. The neurological symptoms can be the initial symptoms or can be late-onset complications of COVID-19.