bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of hypotension during the alveolar recruitment maneuver in spine surgery: A prospective observational study
Authors: Min Ji Young , Chang Hyun Jae , Kim Sung Jun , Cha Seung Hee , Jeon Joon Pyo , Kim Chang Jae , Chung Mee Young 
Published: November 2022

Abstract
Background: Atelectasis can occur in many clinical practices. One way to prevent this complication is through the alveolar recruitment maneuver (ARM). However, hemodynamic compromise can accompany ARM. This study aims to reduce the hemodynamic effect of ARM by predicting hypotension during ARM using a non-invasive method.
Methods: 94 American Society of Anesthesiologists (ASA) physical status I-II patients aged 19 to 75 with scheduled surgery were enrolled. After anesthesia, we performed a stepwise ARM by MAQUET Flow I. Data on the mean blood pressure (MBP), heart rate, pleth variability index (PVI) and perfusion index (Pi), cardiac index (CI), and stroke volume variation (SVV) were collected before induction of anesthesia (T0), just before ARM (T1), at the start of ARM(T2), 0.5 min(T3), 1 min (T4), 1.5 min (T5, end of ARM), and 2 min after the beginning of ARM (T6).
Results: Hypotension was defined as when the MBP at T5 decreased by 20% or more compared to the baseline mean blood pressure; 75 patients developed hypotension during ARM. Pi was considerably higher in the hypotension group than the non-hypotension group before induction. The area under the receiver operating characteristic curve of Pi for predicting hypotension during ARM was 0.718 (95% CI 0.615~0.806; p=0.004), and the threshold value of the Pi was 2.4.
Conclusion: A Higher Perfusion index value before induction of anesthesia can be used to predict the development of hypotension during ARM. Prophylactic management of the following hypotension during ARM could be considered in high baseline Pi patients.
Carbon dioxide emissions and the Environmental Kuznets Curve: evidence from ASEAN
Authors: Ponce Brian Jason H. , Manlangit Ariane T. 
Published: November 2022

Abstract
We examined the non-linear relationship of carbon dioxide emissions (CO2) with economic growth and energy consumption using a panel data consisting of the ten ASEAN member states from 1960 to 2021. The order of integration of each series in the study were verified by the IPS test, Fisher-ADF test, and the Fisher-PP test. The existence of a cointegrating relationship between the variables being studied were verified by the Kao test and the Pedroni test. We find strong empirical evidence supporting the validity of the Environmental Kuznets Curve hypothesis in the ASEAN region, suggesting the existence of a per capita income turning point which is approximately equal to USD 4,808.85. Upon reaching this point, CO2 emissions and economic growth in the ASEAN region will begin to decouple, implying the existence of an environmentally sustainable economic growth path beyond the turning point. The results of the study suggest that the ASEAN member states should design coordinated strategic plans to mitigate carbon dioxide emissions by promoting the use of renewable energy sources without compromising economic growth in the region.
JEL classification: Q40, Q53, Q56
The quantitative investigation of spark plasma on skin parameters: skin elasticity, thickness, density, and biometric characteristics
Authors: Ghasemi Erfan , Nilforoushzadeh Mohammad Ali , Khani Mohammadreza , Amirkhani Mohammad Amir , Nouri Maryam , Charipoor Parisa , Eftekhari Mohammad , Izadpanah Samira , Shokri Babak 
Published: November 2022

Abstract
Cold atmospheric plasma has been developed and utilized as a novel technique for skin rejuvenation because of its various effects on cells and living things. This study investigated the accuracy of this claim and any possible side effects of using spark plasma to rejuvenate skin. The present work is the first quantitative investigation using animal models.
12 Wistar rats were divided into two groups for this investigation. To compare the skin's natural process with the treated skin, the first group underwent a single session of plasma therapy, while the second group served as the control group. The back of the necks of the samples was shaved for 20 cm. Before beginning treatment, the MPA9 multifunctional skin tester was used to determine the melanin index, erythema index, and transepidermal water loss (TEWL). The skin's thickness and density were assessed using sonography, and its elasticity index was calculated using a Cutometer.
The samples were exposed to plasma radiation in the designated area (in a triangular pattern). The signs mentioned above were examined immediately after the following therapy and at the weekly appointment, 2-4 weeks later. Optical spectroscopy was also used to demonstrate the presence of active species.
Transcriptome Analysis and Single-Cell Sequencing Analysis Reveal the Prognostic Value and Immune Landscapes of CD276 in Pan-Cancer and Clinical Validation in Glioblastoma
Authors: Dai Lirui , Guo Xuyang , Xing Zhe , Tao Yiran , Liang Wulong , Shi Zimin , Hu Weihua , Zhou Shaolong , Wang Xinjun 
Published: November 2022

Abstract
Background
CD276, also known as B7-H3, is one of the most important immune checkpoints of CD28 and B7 families, and its abnormal expression is closely associated with cancers. It has been discovered that CD276 can inhibit the function of T cells, which may become a promising immunotherapy target for cancers.
Methods
Since there are few systematic studies on CD276 in cancers, this study used single-cell sequencing and bioinformatics methods to analyze the expression patterns, clinical significance, prognostic value, epigenetic alterations, DNA methylation level, tumor immune cell infiltration and immune functions of CD276 in cancers. In addition, we performed a simple validation of the above analysis using RT-qPCR assay.
Results
The results showed that CD276 is highly expressed and often associated with poorer survival and prognosis in most cancers. In addition, CD276 expression was closely associated with T cell infiltration, immune checkpoint genes, immunoregulatory interactions between lymphoid and a non-lymphoid cell. It is worth mentioning that CD276 expression was significantly higher than normal controls by RT-qPCR in glioblastoma (GBM), and the co-expression network, biological function and chemotherapeutic drug sensitivity of CD276 in GBM were further explored.
Conclusions
Our findings reveal important roles of CD276 in different cancers, especially GBM, and may become a potential cancer biomarker.
Spatial characterization and quantification of CD40 expression across cancer types
Authors: Bates Katherine M. , Vathiotis Ioannis , MacNeil Tyler , Ahmed Fahad Shabbir , Aung Thazin Nwe , Katlinskaya Yuliya , Bhattacharya Sabyasachi , Psyrri Amanda , Yea Steven , Parkes Amanda , Sadraei Nooshin Hashemi , Roychoudhury Siddharta , Rimm David L. , Gavrielatou Niki 
Published: November 2022

Abstract
Background
CD40, a TNF receptor family member, is expressed by a variety of immune cells and is involved in the activation of both adaptive and innate immune responses. Here, we used quantitative immunofluorescence (QIF) to evaluate CD40 expression on the tumor epithelium of solid tumors in large patient cohorts of lung, ovarian, and pancreatic cancers.
Methods
Tissue-biopsy samples from nine different solid tumors (bladder, breast, colon, gastric, head and neck, non-small cell lung cancer (NSCLC), ovarian, pancreatic and renal cell carcinoma), constructed in tissue microarray format, were initially assessed for CD40 expression by QIF. CD40 expression was then evaluated on the large available patient cohorts for three of the tumor types demonstrating high CD40 positivity rate; NSCLC, ovarian and pancreatic cancer. The prognostic impact of CD40 expression on tumor cells was also investigated.
Results
CD40 expression on tumor cells was found to be common, with 80% of the NSCLC population, 40% of the ovarian cancer population, and 68% of the pancreatic adenocarcinoma population displaying some degree of CD40 expression on cancer cells. All of three of these cancer types displayed considerable intra-tumoral heterogeneity of CD40 expression, as well as partial correlation between expression of CD40 on tumor cells and on surrounding stromal cells. CD40 was not found to be prognostic for overall survival in NSCLC, ovarian cancer, or pancreatic adenocarcinoma.
Conclusions
The high percentage of tumor cells expressing CD40 in each of these solid tumors should be considered in the development of therapeutic agents designed to target CD40.
Nutritional evaluation of shrimp waste and its inclusion in laying diet for European quails
Authors: Fileto Juliana Braga , Freitas Ednardo Rodrigues , Nepomuceno Rafael Carlos , Gomes Thalles Ribeiro , Silva Valquíria Sousa , Santos Edibergue Oliveira dos , de Souza Otoniel Félix , Watanabe Germana Costa Aguiar , de Oliveira Paula Joyce Delmiro 
Published: November 2022

Abstract

The present research aimed to evaluate the shrimp waste meal (SWM) in the diet of European quails in the production phase. Firstly, a metabolism trial was carried out with 96 quails of 28 days of age distributed in an completely randomized design (CRD) with three treatments (reference diet and two test diets in which SWM replaced 20% and 40% of the reference diet) and four replications of eight birds. It was observed that the nutritional composition of SWM is within the variation found in the literature, differing only in the sodium content. There was no difference in apparent metabolizable energy (AME) and apparent corrected for nitrogen balance (AMEn) values. In the performance trial 200 quails of 28 weeks of age were distributed in a CRD with four treatments (0, 5, 10 and 15.0% of inclusion of SWM) and five replications of ten birds. There was reduction in the nitrogen metabolization coefficient (NMC) with the inclusion of 15% SWM. The feed intake, production and egg mass worsened with 15% inclusion, causing a linear reduction of these variables. The inclusion of SWM at all levels reduced the values of specific gravity and Hugh units, and the level 15% promoted reduction in shell percentage and shell thickness. No difference was observed on any of the economic variables. It was concluded that the AMEn of SWM is 2,377 kcal/kg DM and that the inclusion of SWM in the diet of quails in production can be up to 10%.
Barriers and facilitators to the recruitment of disabled people to clinical trials: a scoping review
Authors: Shariq Sameed , Pinto Alexandra Cardoso , Budathoki Shyam Sundar , Miller Marie , Cro Suzie 
Published: November 2022

Abstract
Introduction: Underrepresentation of disabled groups in clinical trials results in an inadequate evidence base for their clinical care, which drives health inequalities. This study aims to review and map the potential barriers and facilitators to the recruitment of disabled people in clinical trials to identify knowledge gaps and areas for further extensive research. The review addresses the question: ‘What are the barriers and facilitators to recruitment of disabled people to clinical trials?’
Methods: The Joanna Briggs Institute (JBI) Scoping review guidelines were followed to complete the current scoping review. MEDLINE and EMBASE databases were searched via Ovid. The literature search was guided by a combination of four key concepts from the research question: 1) Disabled Populations, 2) Patient Recruitment, 3) Barriers and Facilitators, and 4) Clinical Trials. Papers discussing barriers and facilitators of all types were included. Papers that did not have at least one disabled group as their population were excluded. Data on study characteristics and identified barriers and facilitators were extracted. Identified barriers and facilitators were then synthesised according to common themes.
Results: The review included 56 eligible papers. The evidence on barriers and facilitators was largely sourced from articles considering empirical evidence and drawing on researcher perceptions and experiences. Carer and clinician perspectives were rarely represented in articles. The most common disability types for the population of interest in the literature were neurological and psychiatric disabilities. A total of five emergent themes were determined across the barriers and facilitators. These were: Risk vs benefit assessment, design and management of recruitment protocol, balancing internal and external validity considerations, consent and ethics, and systemic factors.
Conclusions: Both barriers and facilitators were often highly specific to disability type and context. Assumptions should be minimised, and study design should prioritise principles of co-design and be informed by a data-driven assessment of needs for the study population. Person-centred approaches to consent that empower disabled people to exercise their right to choose should be adopted in inclusive practice. Implementing these recommendations stands to improve inclusive practices in clinical trial research, serving to produce a well-rounded and comprehensive evidence base.
Correlated flat bands and quantum spin liquid state in a cluster Mott insulator
Authors: Hu Jiayu , Zhang Xuefeng , Hu Cong , Sun Jian , Wang Xiaoqun , Lin Hai-Qing , Li Gang 
Published: November 2022

Abstract
Flat bands are rare in pristine solid systems and are unstable against electronic correlations or other types of order. Compared to the atomic scale Hubbard systems and the Moiré materials, where the electronic correlations are confined to the lattice sites in the former and operate in a long-range fashion in the latter, flat band systems with short-range interactions that are free of spontaneous symmetry breaking are severely lacking. Such systems would nicely interpolate the atomic Mott insulator and the Moiré correlated insulators, providing a platform for understanding the connection of the two phases. With elegant analytical analysis and further verified by advanced numerical calculations, we convincingly reveal that monolayer Nb3Cl8 is a novel pristine flat band system with short-range nonlocal interactions. We provide strong evidence for it being a cluster Mott insulator and argue that it may constitute a rare candidate for molecular quantum spin liquid with flat bands. Furthermore, based on the cluster Mott insulator picture, we nicely solved the discrepancy recently observed in angle-resolved photoemission spectroscopy and density-functional theory calculations.
Bilinear form, Pfaffian, soliton and breather solutions for a (2+1)-dimensional generalized Konopelchenko-Dubrovsky-Kaup-Kupershmidt system in fluid mechanics and plasma physics
Authors: Cheng Chong-Dong , Tian Bo , Shen Yuan , Zhou Tian-Yu 
Published: November 2022

Abstract
In this paper, a (2+1)-dimensional generalized Konopelchenko-Dubrovsky-Kaup-Kupershmidt system in fluid mechanics and plasma physics is studied. Bilinear form under certain constraints is given via the Hirota method. The Nth-order Pfaffian solutions are proved via the Pfaffian technique, where N is a positive integer. N-soliton and the higher-order breather solutions are derived from the Nth-order Pfaffian solutions. Y/X-type solitons are constructed via adding some conditions to the N-soliton solutions. Elastic and inelastic interactions between the two solitons are presented graphically. Y/X-type breathers are constructed via adding some conditions to the higher-order breather solutions. Y-type breathers describe the inelastic interactions between the two breathers, and the X-type breathers describe the different two-breather structure. We investigate the influence of the coefficients in the system on those solitons and breathers as follows: the amplitudes of those solitons and breathers are related to l1 and l2; the periods of those breathers are related to l1, l2, l3 and l5, where l1, l2, l3 and l5 are the constant coefficients in the system.
A Local Water Molecular-heating Strategy for NIR Long-lifetime Imaging-guided Photothermal Therapy of Deep-tissue-bearing Tumor
Authors: Kang Dongkyu , Kim Hyung Shik , Han Soohyun , Lee Yeonju , Kim Young-Pil , Lee Dong Yun , Lee Joonseok 
Published: November 2022

Abstract
1.0 µm near-infrared (NIR) is considered unsuitable as an imaging and analytical signal in biological environments owing to the strong absorption of water at around the regions. Conversely, the 1.0 µm NIR can be converted to heat and used as a local water-molecular heating strategy for photothermal therapy of biological tissues. Herein, we designed a Nd-Yb co-doped nanomaterial (water-heating nanoparticles (NPs)) as a strong 1.0 µm emissive NP to target the absorption band of water. Furthermore, introducing Tm ions into the water-heating NPs improved the NIR lifetime, and it was developed as an NIR imaging-guided water-heating probe (water-heating NIR NPs). In the glioblastoma multiforme (GBM) mouse model, tumor-targeted water-heating NIR NPs reduced the tumor volume by 78.9% in the presence of high-resolution intracranial NIR long-lifetime imaging. Hence, water-heating NIR NPs can be used as a novel nanomaterial for imaging and photothermal ablation in deep-tissue-bearing tumor therapy.
Neural Network Modeling and Dynamic Behavior Prediction of Nonlinear Dynamic Systems
Authors: Zhang Luying , Sun Ying , Wang Aiwen , Zhang Junhua 
Published: November 2022

Abstract
In the complex dynamic problems of practical engineering, the method of establishing dynamic equations and numerical analysis based on theories of mechanics is difficult to meet the needs of high dimension, multi-scale and high precision. In this paper, data-driven models of nonlinear dynamic systems are built through neural network. The numerical solution of state equations is used to simulate the experimental data as well as training data of neural network. The loss function with two coefficients is constructed according to the relationship between the data. Forward Euler method and the trained neural network are combined to predict the response data of different excitation frequencies. Then, whole data-driven modeling and substructure data-driven modeling are presented to model and analyse a five-degree-of-freedom duffing oscillator. By comparison, the prediction accuracy of substructure data-driven modeling is higher. Furthermore, the influence of loss function, hidden layer, training data and noise on the accuracy of the model is studied. The results show that the selection of training data and the number of hidden layers have a great impact on the prediction ability, and verify accuracy, generalization and robustness of the model. In order to improve the prediction accuracy of substructure data-driven modeling, adjustable learning rate is adopted in the optimizer. The effects of adding control parameters to the network input (APNI) and not adding control parameters to the network input (NAPNI) on the dynamic characteristics are considered respectively. The prediction accuracy of the model can be effectively improved by adding control parameters to the network input.
Evaluation of dietary hemp seed meal as soybean meal substitution on productive performance, egg quality, and yolk fatty acid composition of laying hens
Authors: Ozturk Ergin , DARMAWAN Arif , ÖZLÜ Şevket , ABACI Samet Hasan 
Published: November 2022

Abstract

Hemp seed meals contain high protein and unsaturated fatty acids which have the potential as a substitute for soybean meal and yield eggs rich in unsaturated fatty acids. Therefore, the study aimed to evaluate the impact of dietary hemp seed meal as a substitute for soybean meal protein on productive performances, egg quality, and yolk fatty acid composition. A total of 120 Lohmann Brown laying hens aged 50 weeks were separated into 4 groups and 10 repetitions with 3 birds each. Birds received treatment without hemp seed meal (control group), or soybean meal substituted with 4%, 8%, and 12% hemp seed meal. Dietary 4% hemp seed meal significantly increased (p < 0.05) feed efficiency and egg production compared to the 8% and 12% hemp seed meal group. Meanwhile, feed intake, egg weight, body weight loss, egg shape index, albumen index, albumen weight, Haugh unit, yolk weight, yolk index, and eggshell thickness had no significant influence (p > 0.05). However, dietary 8% and 12% hemp seed meal significantly increased (p < 0.05) eggshell weight and yolk color score compared to the control and 4% hemp seed meal group. There was a significant increase (p < 0.05) in omega-3 fatty acid levels and a significant decrease in yolk omega-6 to omega-3 fatty acids ratio with an increase in dietary hemp seed meal. It concluded that dietary 4% hemp seed meal as soybean meal substitution was able to increase egg production, and feed efficiency compared to the level of 8% and 12% hemp seed meal. Increasing dietary levels of hemp seed meal increased eggshell weight, yolk color, and omega-3 fatty acids content, and decreased the omega-6 to omega-3 fatty acids ratio.
Climate warming will affect the range dynamics of East Asian Meehania species: A maximum entropy approach.
Authors: Tiamiyu Bashir Bolaji , Ngarega Boniface K. , Zhang Xu , Zhang Huajie , Li Lijuan , Sun Jiao , Deng Tao , Wang Hengchang 
Published: November 2022

Abstract

Global climate change is among the major anthropogenic factors impacting species distribution, with significant conservation implications. Yet, little is known about the effects of climate warming on the distributional shifts of East Asian species. In the current study, we used the maximum entropy model (MaxEnt) to determine present and possible future habitats for five Meehania species occurring in the East Asian region. Our objectives were to evaluate how climate change would influence the species' habitat under current and future climate scenarios (Representative Concentration Pathways 4.5 and 8.5). The mean area under the curve (AUC) ranged between 0.896 and 0.973, while the TSS values for all species varied between 0.811 and 0.891. The modelled current habitat of the species corresponded with the recorded distribution localities, confirming the model's robustness. Analysis of variable contribution demonstrated that the distribution of the species had differential environmental requirements; however, isothermality, precipitation of driest month, and elevation variables were among the main influential variables. Based on present climatic conditions, the projected habitat suitability maps showed a total of 662,846.0 to 2,039,180.1 km2 as suitable regions for the distribution of Meehania species. In addition, there was a substantial loss in habitat range under future climatic scenarios for all the species. While the East Asian region is rich in biodiversity, more attention should be given to its management conservation. The current findings provide a scientific foundation for the conservation of Meehania and other species' habitats in the region.
Soliton solutions and their degenerations in the (2+1)-dimensional Hirota-Satsuma-Ito equations with
time-dependent linear phase speed
Authors: Chen Xin , Liu Yaqing , Zhuang Jianhong 
Published: November 2022

Abstract
This paper focuses on the exact soliton solutions of the (2+1)-dimensional generalized Hirota-Satsuma-Ito equations with time-dependent linear phase speed. Based on the Painlevé integrability test of this equation, the condition of the integrability is determined. Then the general N-soliton solutions are constructed by Hirota bilinear method. Not only the expressions of exact solutions and their degenerations, but also the spatial structures are presented for different choices of the parameters, including the line soliton, periodic soliton, lump soliton and their interaction forms.