bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH LATIHAN SHOOTING DENGAN METODE BEEF TERHADAP AKURASI FREE THROW SISWI EKSTRAKURIKULER BASKET SMK NEGERI 4 BANDAR LAMPUNG
Authors: Alamsyah Ichlasul Rizki , Mahfud Imam , Aguss Rachmi Marsheilla 
Published: September 2022

Tujuan dari penelitian ini untuk mengetahui apakah ada pengaruh latihan shooting dengan metode beef terhadap akurasi free throw siswi ekstrakurikuler basket SMK Negeri 4 Bandar Lampung. Penelitian ini menggunakan metode eksperimen. Metode penelitian eksperimen termasuk dalam metode penelitian kuantitatif. eksperimen berarti mencoba, mencari, dan mengkonfirmasi. eksperimen adalah metode penelitian kuantitatif yang digunakan untuk mengetahui pengaruh variabel independen (treatment/perlakuan) terhadap variabel dependen (hasil) dalam kondisi yang terkendalikan. Kondisi dikendalikan agar tidak ada variabel lain. Populasi pada penelitian ini adalah 15 orang siswi SMK Negeri 4 Bandar lampung yang mengikuti ekstrakurikuler bolabasket. Dikarenakan populasi terdiri dari 15 orang, maka pada penelitian ini menggunakan teknik total sampling dan menggunakan metode eksperimen one groups pretest posttest. Hasil dari penelitian menunjukkan bahwa terdapat pengaruh yang signigikan latihan shooting dengan metode beef dengan hasil uji t hitung 9.909 > t tabel 1.761. Lalu terdapat perbedaan setelah diberikan perlakuan sebesar 2.13 yang sebelumnya 1.87 menjadi 4.00.
Estudio de las sanciones indirectas, derivadas de la inhabilitación por inconsistencias en la declaración del “valor agregado ecuatoriano” (VAE) en la contratación pública
Authors: Ordóñez-Carpio Fernando , Vega-Crespo Elizabeth 
Published: September 2022

En el presente artículo, se estudia los actos administrativos que dan como resultado la suspensión en el “Registro Único de Proveedores RUP”, impuesta por el “Servicio Nacional de Contratación Pública” SERCOP, a proveedores del Estado, que han proporcionado información o realizado una declaración errónea respecto de su calidad de productor nacional, dentro de un procedimiento de contratación pública; pero que, no obstante la aplicación de la referida sanción, hallándose bloqueados en el “Portal de Compras Públicas”, se ven impedidos de cumplir otras obligaciones previamente contraídas, como la suscripción de contratos adjudicados con anterioridad en otros procesos; y, por consecuencia de un evento forzoso ajeno a su voluntad, son objeto de una sanción significativamente superior.
Se delinea los mecanismos a utilizar para conseguir su rehabilitación en el Sistema Nacional de Contratación Pública, así como las eventuales acciones judiciales y administrativas para conseguir el resarcimiento de los daños injustamente ocasionados.
SOSIALISASI TENTANG PENANGANAN PERTAMA PADA CEDERA OLAHRAGA DI KELURAHAN UWUNG JAYA
Authors: Juliansyah Reno Rizki , Abidin Dindin , Mamesah Elly Diana 
Published: September 2022

Penulisan ini dibuat untuk memberikan pemahaman dan gambaran kepada masyarakat luas dengan cara memberi edukasi atau langkah-langkah yang tepat khususnya untuk penanganan pertama pada cedera olahraga. Karena masih banyak masyarakat di sekitar kita yang masih belum paham bagaimana cara menangani cedera yang tepat khususnya tentang penanganan pertama jika terjadi cedera pada saat berolahraga. Kegiatan ini dilakukan dalam 4 tahapan dengan total 3 kegiatan inti, dengan kurun waktu pelaksanaan 15 hari yang dimulai dari tanggal 27 Februari 2022 – 12 Maret 2022 melalui zoom meet dengan jumlah 17 peserta dan whatsapp sebagai media komunikasi serta pemberian program lanjutan dengan peserta supaya lebih mudah untuk berkoordinasi antara pelaksana kegiatan dan peserta/remaja RT 006 dan semua kegiatan dilaksanakan secara online. Tujuan dari program ini adalah remaja RT006 Kelurahan Uwung jaya mendapatkan pemahaman yang baik dan benar sesuai dengan teori yang diberikan tentang penanganan pertama pada cedera olahraga, adapaun hasil atau dampak dari program ini yaitu remaja RT006 menjadi tahu bagaimana cara serta langkah awal penanganan pertama jika terjadi cedera dilingkungan RT 006 Kelurahan Uwung Jaya.
SEJARAH DAN PERKEMBANGAN MADRASAH DI INDONESIA
Authors: Samsudin Mohamad , Haniefa Rifda 
Published: September 2022

Madrasa is one form of Islamic educational institution that has gone through a long evolutionary process. Starting from the mosque which was used as a means of education, then kuttab, and so on turned into a madrasa. The process of evolution of the madrasa to become an educational institution that is recognized as capable of producing a superior generation of Islam, of course, has not escaped the long journey of history that it has gone through with challenges. Until finally the madrasa arrived at the archipelago, the historical carvings inscribed by Islamic leaders were also full of exhausting struggles. From then until now, and maybe until when, can not be determined. This paper is intended to find out how the history of madrasa, from classical to modern times, from the Middle East to Indonesia, and the challenges faced for its existence. In this study, the authors use research that is library research using written materials that have been published in the form of books and international journals. This research uses a historical and educational approach. The results of the research in this study indicate that in the history of the growth and development of madrasa in Indonesia, there are two momentums that determine the existence of madrasa: first, the 1975 Joint Decree of Three Ministers (SKB 3 Menteri) which became the entry point for the recognition of madrasa as Islamic educational institutions that is equivalent to public schools; second, the National Education System Law Number 2/1989 which makes madrasa not only educational institutions that is equivalent to public schools, more than that, madrasa is recognized as public schools with Islamic characteristics. In other words, madrasa can be said to be "plus public school". On the other hand, this recognition is a matter of pride for the madrasa, but on the other hand it is also a challenge that needs to be proven, whether the madrasa is able to carry out this dual status.
Laughing with Young Ben: Vivian Grey, Flim-Flams!, and the Perplexities of Satirical Writing
Authors: Villa Luisa 
Published: September 2022

From his unpublished juvenilia to The Young Duke (1831), Benjamin Disraeli tested his literary potential mainly through writing in the satirical, comic, or even farcical mode. One way or another, all his fictional works from 1826 to 1830 were meant to make people laugh, or at least smile, and appreciate the young author’s wit and humorous talent for irony and comic exaggeration. He sidelined this practice in the 1830s, when he mainly experimented with other narrative genres and modes of representation, eventually parading in Venetia (1837) a new sobriety of tone such as suited an aspiring Tory politician in the year of Victoria’s accession. Working within this developmental framework, my article sets out to investigate the young Disraeli’s penchant for laughter in connection with the fun-loving vein running in the family. It focuses on Vivian Grey, Part I, and relates it to Flim-Flams!, or, the Life and Errors of My Uncle and the Amours of My Aunt (1805), a quirky satirical ‘romance’ Isaac D’Israeli completed round about the time his eldest son was born. In highlighting the contextual similarities and carnivalesque qualities of the two works, the article offers an eccentric approach to the Romantic/early-Victorian generational changeover.
Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation
Authors: Gami Bansuri , Bloch Khalida , Mohammed Shahansha M. , Karmakar Srikanta , Shukla Satyajit , Asok Adersh , Thongmee Sirikanjana , Ghosh Sougata 
Published: September 2022

The application of nanotechnology is gaining worldwide attention due to attractive physico-chemical and opto-electronic properties of nanoparticles that can be also employed for catalytic dye degradation. This study reports a phytogenic approach for fabrication of silver (AgNPs) and gold nanoparticles (AuNPs) using Leucophyllum frutescens (Berl.) I. M. Johnst (Scrophulariaceae) leaf extract (LFLE). Development of intense dark brown and purple color indicated the synthesis of AgNPs and AuNPs, respectively. Further characterization using UV-visible spectroscopy revealed sharp peak at 460 nm and 540 nm for AgNPs and AuNPs, respectively that were associated to their surface plasmon resonance. High resolution transmission electron microscope (HRTEM) revealed the spherical shape of the AgNPs, whereas anisotropic AuNPs were spherical, triangular and blunt ended hexagons. The majority of the spherical AgNPs and AuNPs were ∼50 ± 15 nm and ∼22 ± 20 nm, respectively. Various reaction parameters such as, metal salt concentration, temperature and concentration of the leaf extract were optimized. Maximum synthesis of AgNPs was obtained when 5 mM for AgNO3 reacted with 10% LFLE for 48 h at 50°C. Likewise, AuNPs synthesis was highest when 2 mM HAuCl4 reacted with 10% LFLE for 5 h at 30°C. Energy dispersive spectroscopy (EDS) showed phase purity of both the nanoparticles and confirmed elemental silver and gold in AgNPs and AuNPs, respectively. The average hydrodynamic particles size of AgNPs was 34.8 nm while AuNPs was 140.8 nm as revealed using dynamic light scattering (DLS) that might be due to agglomeration of smaller nanoparticles into larger clusters. ZETA potential of AgNPs and AuNPs were 0.67 mV and 5.70 mV, respectively. X-ray diffraction (XRD) analysis confirmed the crystallinity of the nanoparticles. Fourier transform infrared spectroscopy (FTIR) confirmed that various functional groups from the phytochemicals present in LFLE played a significant role in reduction and stabilization during the biogenic synthesis of the nanoparticles. The bioreduced AgNPs and AuNPs catalytically degraded Rhodamine B dye (RhB) in presence of UV-light with degradation rate constants of 0.0231 s−1 and 0.00831 s−1, respectively. RhB degradation followed a first order rate kinetics with 23.1 % and 31.7% degradation by AgNPs and AuNPs, respectively.
Synthesis, docking studies, biological activity of carbon monoxide release molecules based on coumarin derivatives
Authors: Liu Huapeng , Chen Yujie , Cui Fujun , Liao Yuan , Wang Xicun 
Published: September 2022

In the present work, we synthesized seven complexes. All complexes were identified by ESI-HRMS, 1H-NMR, 19F-NMR and 13C-NMR spectroscopies. The synthesized complexes were tested for their anticancer activities in vitro against three different human cell lines, including breast MDAMB231, cervical Hela, liver HepG2. IC50 values of complexes 1-7 were 34.98–667.35 µM. Complex 5 revealed higher sensitivity towards MDAMB231 cells with IC50 values 34.98 μM in comparison to 5-FU as positive control. Moreover, complex 5 caused a decrease of mitochondrial membrane potential and effectively induced ROS production against MDAMB231 cells. Western blot analysis showed that complex 5 could up-regulate the expression of Bax protein and down-regulate the expression of Bcl-2, activate Caspase-3, slightly down-regulate the expression of HO-1. The docking studies showed that complex 5 could be interacted with Bcl-2 protein through hydrophobic interactions, hydrogen bonds and salt bridges to enhance the binding affinity. All the analyzed coumarins obeyed the Lipinski’s rule of five for orally administered drugs. Based on the aforementioned results, it suggests that the complex induced apoptosis cell via mitochondria pathways. Collectively, complex 5 could be considered as a promising hit for new anti-breast cancer agents. Carbonyl cobalt CORMs, as potential anticancer therapeutic agents, provided a new idea for the development of metal anticancer drugs.
A training programme for medical students in providing spiritual care to people with advanced diseases and their loved ones: A case study from the Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland
Authors: Fopka-Kowalczyk Małgorzata , Groves Richard , Larkin Philip , Krajnik Małgorzata 
Published: September 2022

PurposeThis article presents the first programme on spiritual care particularly for people with advanced life-limiting illness including heart failure, lung disease or cancer for medical students in Poland implemented at the Collegium Medicum in Bydgoszcz of the Nicolaus Copernicus University in Toruń.Methods and materialsSeveral steps were identified for the development of the first programme on spirituality for medical students at the Collegium Medicum in Bydgoszcz including preliminary work on the content of the programme, agreement on key concepts, terms, and definitions; consultations with teachers and review of the literature.ResultsThe first Polish spiritual curriculum for medical students was implemented. The spirituality curriculum will potentially contribute to better care for the people with advanced illnesses such as heart failure, chronic lung disease or cancer and improve the quality of relationships between professionals and patients.ConclusionThe article presents the content of the program, the expected learning objectives and ascribed teaching methods, along with the preliminary evaluation made by students.
QT interval is correlated with and can predict the comorbidity of depression and anxiety: A cross-sectional study on outpatients with first-episode depression
Authors: Tang Mingcong , Xi Juzhe , Fan Xiwang 
Published: September 2022

ObjectPatients with depression are at an increased risk for developing cardiovascular diseases. The associations between electrocardiogram (ECG) abnormalities and the severity of psychiatric disorders, such as depression and anxiety, have not been clearly elucidated. The present study aims to investigate the associations between depression and anxiety symptoms with ECG indices, and to predict the severity of depression and anxiety using ECG indicators.Methods61 outpatients with first-episode depression from the Shanghai Pudong New Area Mental Health Center were selected and met the diagnostic criteria of DSM-IV. All participants provided self-reported scores on the Zung Self-Rating Depression Scale (SDS) and Zung Self-Rating Anxiety Scale (SAS) and underwent the standard 12-lead ECG assessment.ResultsAmong the 61 included outpatients (mean [standard deviation, SD] age: 37.84 [13.82] years; 41[67.2%] were female), there were 2 (3.3%) outpatients without depression symptoms, 16 (26.2%) with mild depression, 19 (31.1%) with moderate depression, and 24 (39.3%) with severe depression. Ten (16.4%) outpatients did not have anxiety symptoms, 19 (31.1%) exhibited mild anxiety, 20 (32.8%) exhibited moderate anxiety, and 12 (19.7%) exhibited severe anxiety. Only 1 (1.6%) outpatient exhibited neither depression nor anxiety, 9 (14.8%) and 1 (1.6%) outpatients only exhibited depression and anxiety, respectively, and most outpatients (50 [82.0%]) had comorbid depression and anxiety symptoms. In the correlation analysis, depression and anxiety severity levels were significantly positively correlated (r = 0.717, p &lt; 0.01). Moreover, categorical anxiety significantly differs in QT interval (p = 0.022), and continuous SAS scores were significantly correlated with QT interval (r = 0.263, p = 0.04). In addition, the correlations between ECG measurements and both categorical depression and continuous SDS scores were not statistically significant. The comorbidity of anxiety and depression was significantly correlated with heart rate (p = 0.039) and QT interval (p = 0.002). Disorder status significantly differed with different QT intervals (p = 0.021). In the prediction analysis, QT interval was the only significant predictor (p = 0.01, b = 0.058, Odds Ratio = 1.059) for comorbid anxiety and depression symptoms.ConclusionThis study found that comorbid symptoms of depression and anxiety were significantly associated with QT interval and heart rate. Additionally, QT interval could predict the comorbidity of these two psychiatric disorders. Further prospective research in a larger and high-risk population is needed.
Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia
Authors: Yu Zhongyang , Liu Zhihao , Jiao Liying , Zhang Song , Nie Liqing , Wang Yueyi , Zhou Liping , Wang Yuhong , Liu Zhihao , Liu Zihan , Xu Xiao , Li Zeyan , Zhou Yuyang , Zhou Huixin , Li Rui , Peng Chen , Yu Lilei , Jiang Hong 
Published: September 2022

ObjectivesThe neural activity of the left stellate ganglion (LSG) is closely related to the occurrence of ventricular arrhythmias (VAs). Bmal1 modulates genes associated with neural activity in the central nervous system. However, few studies indicated the role of Bmal1 in the LSG and the subsequent effect on the heart. Therefore, we aimed to investigate the influence of Bmal1 knockdown in the LSG on its neural activity and cardiac electrophysiology and to explore the mechanisms.Materials and methodsWe used adeno-associated virus (AAV) to knock down Bmal1 in the LSG. Male beagles were randomized into the Bmal1 knockdown group and the control group. After 4 weeks of injection, the LSG function, neural activity, left ventricular effective refractory period (ERP), and action potential duration (APD) were measured. Electrocardiography for 1 h was recorded for VAs analysis after myocardial ischemia. Nerve growth factor (NGF) and c-fos in the LSG were quantified by immunofluorescence. Transcriptomic analysis was performed to assess the gene expression in the LSG.ResultsBmal1 was sufficiently knocked down by AAV. Compared with the control group, heart rate variability (HRV) in the knockdown group was altered. Bmal1 knockdown inhibited neural activity and function of LSG. It also prolonged ERP as well as APD90. Ischemia-induced VAs were significantly reduced. Nerve growth factor (NGF) and c-fos in the LSG were reduced. Bmal1 knockdown led to the expression changes of genes associated with neural activity in the LSG.ConclusionBmal1 knockdown in the LSG suppresses neural activity and prevents ventricular arrhythmias after myocardial ischemia.
The effect of SGLT-2i administration on red blood cell distribution width in patients with heart failure and type 2 diabetes mellitus: A randomized study
Authors: Katsiadas Nikolaos , Xanthopoulos Andrew , Giamouzis Grigorios , Skoularigkis Spyridon , Skopeliti Niki , Moustaferi Evgenia , Ioannidis Ioannis , Patsilinakos Sotirios , Triposkiadis Filippos , Skoularigis John 
Published: September 2022

BackgroundRecent studies suggest that the pivotal mechanism of sodium glucose co-transporter-2 inhibitors (SGLT-2i) favorable action in patients with heart failure (HF) and type 2 diabetes mellitus (DM) is the stimulation of erythropoiesis via an early increase in erythropoietin (EPO) production which leads to hematocrit rise. Red blood cell distribution width (RDW) is a simple hematological parameter which reflects the heterogeneity of the red blood cell size (anisocytosis). Since, EPO has been also implicated in the pathophysiology of RDW increase, the current mechanistic study examined the effect of SGLT-2i administration on red blood cells size (RDW) in patients with HF and DM.MethodsThe present was a prospective single-center study. Patients (N=110) were randomly assigned to dapagliflozin (10 mg a day on top of antidiabetic treatment) or the control group. Inclusion criteria were: (a) age &gt; 18 years, (b) history of type 2 DM and hospitalization for HF exacerbation within 6 months. The evaluation of patients (at baseline, 6 and 12 months) included clinical assessment, laboratory blood tests, and echocardiography. Data were modeled using mixed linear models with dependent variable the RDW index. In order to find factors independently associated with prognosis (1-year death or HF rehospitalization), multiple logistic regression was conducted with death or HF rehospitalization as dependent variable.ResultsAn RDW increase both after 6 and after 12 months was observed in the SGLT-2i (dapagliflozin) group (p &lt; 0.001 for all time comparisons), whereas RDW didn't change significantly in the control group. The increase in RDW was positively correlated with EPO, while negatively correlated with ferritin and folic acid (p &lt; 0.005 for all). Baseline RDW was significantly associated with 1-year death or rehospitalization, after adjusting for group (SGLT-2i vs. control), age, gender, smoking and BMI at baseline.ConclusionRDW increased with time in patients with HF and DM who received SGLT-2i (dapagliflozin). The increased RDW rates in these patients may stem from the induction of hemopoiesis from dapagliflozin. Baseline RDW was found to be independently associated with outcome in patients with HF and DM.
Impact of liver fibrosis and nodules formation on hemodynamics in young adults after total cavopulmonary connection. A magnetic resonance study
Authors: Chaloupecký Václav , Jičínská Denisa , Tomek Viktor , Materna Ondřej , Gebauer Roman , Poruban Rudolf , Antonová Petra , Adla Theodor , Štefánek Matěj , Illinger Vojtěch , Kotaška Karel , Janoušek Jan 
Published: September 2022

BackgroundThe aim of this study was to analyze the relation between the hepatic fibrosis markers, liver morphology and hemodynamics assessed by magnetic resonance imaging (MRI) after total cavopulmonary connection (TCPC).Materials and methodsAdult patients after TCPC performed in childhood between 1993 and 2003 are the subjects of this observational study. The follow-up protocol consisted of clinical and echocardiographic examination, liver elastography, cardiopulmonary exercise test, MRI hemodynamics and liver morphology assessment and direct enhanced liver fibrosis (ELF) test.ResultsThe cohort consisted of 39 patients (46% female) with a median age at study 26 (IQR 23–28) years and interval from TCPC 21 (IQR 20–23) years. There was no correlation between ELF test and any MRI variables, but procollagen III amino-terminal peptide (PIIINP), a single component of ELF test, correlated significantly with ventricular end-diastolic volume (r = 0.33; p = 0.042) and inferior vena cava flow (r = 0.47; p = 0.003). Fifteen (38%) patients with liver nodules had compared to other 24 patients higher end-diastolic volume (ml/m2) 102.8 ± 20.0 vs. 88.2 ± 17.7; p = 0.023, respectively. PIIINP correlated significantly with inferior vena cava flow (r = 0.56; p = 0.030) and with end-diastolic volume (r = 0.53; p = 0.043), but only in patients with liver nodules.ConclusionGradual progression of liver fibrosis, particularly hepatic arterialization caused by liver nodules formation, increases inferior vena cava flow and subsequent ventricular volume overload may further compromise single ventricle functional reserve in adult patients after TCPC.