bluuebunny/crossref_metadata_2025_split huggingface dataset:
Athar Istīʿāb al-Mufradāt wa-al-Qawāʿid ʿalá Kafā’at al-Kitābah al-Imlā’īyah li-al-Talāmīdh fī al-Faṣl al-Thāmin bi-Madrasat Al-Waṭanīyah al-Thānawīyah al-Islāmīyah Kebumen
Authors: Niswah Fiki Khoerun , Hadjar Ibnu , Shiddiq Mahfudz 
Published: April 2022

Many students at Wathoniyah Islamiyah Junior High School (Madrasah Tsanawiyah) Kebumen graduated from public elementary schools, so many had not have adequate knowledge of the Arabic language. This study is essential because students' diverse vocabulary and grammatical comprehension influenced their writing and spelling ability. The current study investigates the influence of vocabulary and grammatical comprehension on eighth grade students' spelling writing abilities at Wathoniyah Islamiyah Kebumen. All eighth-grade students at Wathoniyah Islamiyah Junior High School were recruited in this research. The study employed a quantitative design and purposive sampling technique to test the sample. The researchers obtained the data using documentation and analyzed the data using multiple regression tests. The results indicated that the F value is 11.250, and the F table with the value from the table at a 5% significance level = 3.385. Therefore, the F count exceeds the F table. The findings also indicated that the students' vocabulary and grammatical knowledge and comprehension have a substantial influence on their spelling and writing skill. Therefore, the research hypothesis is acceptable.
Identification of Hub Genes and Biomarkers between Hyperandrogen and
Normoandrogen Polycystic Ovary Syndrome by Bioinformatics Analysis
Authors: Li Xiaodong , Hu Baoshan , Zhang Tianwei , Liu Yang 
Published: April 2022

Background:
The common and divergent genetic mechanisms of hyperandrogen (HA)
and normoandrogen (NA) polycystic ovary syndrome (PCOS) are currently unknown.

Objective:
This study aimed to explore the hub genes and potential mechanisms of HA and NA
PCOS through bioinformatics analysis.

Methods:
The GSE137684 dataset was downloaded from the Gene Expression Omnibus (GEO)
database. The co-expressed genes and differentially expressed genes (DEGs) between HA and NA
PCOS samples were functionally annotated by gene ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) enrichment analyses. The protein-protein interaction (PPI) network
of the DEGs was constructed and visualized using STRING and Cytoscape, respectively, and the
hub genes were screened using the Cytohubba plug-in. The transcription factors (TFs) of these hub
genes were identified with the JASPAR database, and the hub gene-TF regulatory network was
constructed.

Results:
A total of 327 DEGs, including 191 upregulated and 136 downregulated genes, were identified
in HA PCOS relative to NA PCOS. Ten hub genes were screened, of which MYC, CAV1,
and HGF were mainly enriched in the Proteoglycans in the cancer pathway. In addition, 47 TFs
were identified that were found to be involved in the regulation of hub genes.

Conclusion:
MYC, CAV1, and HGF are potential diagnostic biomarkers and therapeutic targets for HA
PCOS.
Is the Alzheimer's Disease Assessment Scale-Cognitive Subscale Useful in
Screening for Mild Cognitive Impairment and Alzheimer's Disease? A
Systematic Review
Authors: Park Seong-Hi , Han Kuem Sun 
Published: April 2022

Background:
Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) are
screened to distinguish whether the cognitive decline in older adults is attributed to pathological
causes rather than normal aging.

Objective:
The purpose of this review was to analyze the diagnostic performance of the Alzheimer's
Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in screening for MCI and AD.

Methods:
Electronic searches were performed on MEDLINE, EMBASE, CINAHL, and PsycArticles
databases using the following keywords: dementia and ADAS-Cog. The Quality Assessment of Diagnostic
Accuracy Studies-2 was used to check the risk of bias in the diagnostic studies.

Results:
We reviewed 14 studies, including 3,875 patients who met the selection criteria. In 2,624
MCI patients from nine studies, the pooled sensitivity of ADAS-Cog was 0.80 (95% confidence interval
[CI], 0.68–0.88), the pooled specificity was 0.84 (95% CI, 0.75–0.90), and the area under the
curve of summary receiver-operating characteristic curves (SROC AUC) was 0.89 (SE = 0.03). In
2,517 AD patients from 10 studies, the pooled sensitivity and pooled specificity were 0.91 (95% CI,
0.86–0.95) and 0.93 (95% CI, 0.88–0.95), respectively, and the sROC AUC was 0.97 (SE = 0.01).
Although sub-analyzed according to age and years of education, there was no significant difference
in the predictive validity of the ADAS-Cog.

Conclusion:
The ADAS-Cog has high predictive validity as a screening tool in both MCI and AD
and has better diagnostic performance in patients with AD. When early screening for AD is desired,
ADAS-Cog is a first-stage screening tool that can be initially employed.
Fibrolipoma of the Median Nerve: An Overview
Authors: Slouma Maroua , Zarrouk Zeineb , Maatoug Feten , Dhahri Rim , Amorri Wajdi , Gharsallah Imen , Metoui Leila , Louzir Bassem 
Published: April 2022

Introduction:
Fibrolipoma of the median nerve is a rare benign lesion responsible for carpal tunnel syndrome. Fibrolipoma is often misdiagnosed. This article aimed to review and summarize current knowledge regarding fibrolipoma of the median nerve. We emphasize the clinical and imaging features of this disease.

Methods:
To examine the characteristics of fibrolipoma of the median nerve, we performed a litera-ture review using MEDLINE. The search included only English studies published from database in-ception to June 2021.

Results:
Forty-six cases of fibrolipoma of the median nerve were included.
Fibolipoma is characterized by diffuse infiltration of peripheral nerves by normal-appearing fibrous and adipose tissues. The fibrolipoma of the median nerve can be responsible for macrodactyly, numbness, paresthesia, and weakness within the median nerve distribution. Ultrasonography shows a fusiform hyperechoic mass along the nerve containing hypoechoic bands corresponding to nerve fascicles.
Magnetic resonance imaging is the gold standard for the diagnosis of fibrolipoma. It typically shows a contrast between the low signal nerve fibers and the high signal fatty tissues, revealing a charac-teristic « cable-like » appearance on axial sections and a «spaghetti-like» appearance on coronal sections.

Conclusion:
Fibrolipoma should be considered in young patients with carpal tunnel syndrome. This review emphasizes the clinical and radiological features of fibrolipoma. We highlight the images of ultrasonography in the diagnosis of rare structural causes of carpal tunnel syndrome.
Assessment of Lumbar Vertebrae Morphology by Computed Tomography
in Older Adults with Osteoporosis
Authors: Lin Chun-Li , Liao Chi-Yang , Chien Chia-Liang , Pu Ta-Wei , Shen Shin-Chieh , Yang Chien-Yi , Yen Ching-Heng 
Published: April 2022

Background:
Hounsfield units (HU) values derived from computerized tomography (CT)
have been used in the diagnosis of osteoporosis in the lumbar spine.

Objective:
This study aimed to identify anatomical dimensions of lumbar vertebrae on CT images,
which were different between older normal, osteopenic, and osteoporotic subjects.

Methods:
This prospective pilot study enrolled 79 older adults. Based on CT measurements of lumbar
vertebrae in HU, participants were classified into three groups: normal (HU > 109), osteopenia (HU:
94-108), and osteoporosis (HU < 93). Altogether, 42 anatomical variables of lumbar vertebrae, L2, L3,
L4, and L5, were measured in each participant by CT, including 24 parameters measurable by MRI or
plain X-ray and 18 parameters measurable by MRI only.

Results:
Among the morphological measurements also measurable by MRI and plain X-ray, the length
upper curve, 50% and 75% of L5, length upper with the cortex of L4, length center of the cortex of L3,
as well as width upper curve 75% of L2, were significantly different between the three groups (p=
0.008, 0.007, 0.035, 0.036, and 0.003 respectively). Among the morphological measurements also
measurable by MRI, only the width upper cortex 75% of L5 and the width lower cortex 25% of L3,
were significantly different between the three groups (p= 0.031 and 0.020, respectively).

Conclusion:
Seven CT morphological measurements may be used as “reference standard” CT measurements
for preliminarily diagnosing osteoporosis and osteopenia in older adults.
Clinical Characterizations and Radiological Findings of COVID-19: A 4
Case Report
Authors: Ye Aihua , Hu Chunhong , Qiao Zhenguo , Liu Dong , Fu Fangfang 
Published: April 2022

Background:
Coronavirus disease 2019 (COVID-19, previously known as novel coronavirus
[2019-nCoV]), first reported in China, has now been declared a global health emergency by
World Health Organization. The clinical severity ranges from asymptomatic individuals to death. Here,
we report clinical features and radiological changes of a cured family cluster infected with COVID-19.

Case Presentation:
In this report, we enrolled a family of 4 members who were admitted to our hospital
in January 2020. We performed a detailed analysis of each patient’s records. All patients underwent
chest computed tomography (CT) examination with 120 kilovolts peak and 150 kilovolt-ampere. Realtime
polymerase chain reaction (RT-PCR) examinations for severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) nucleic acid were done using nasopharyngeal swabs.

Conclusion:
In the family members infected with COVID-19 who were accompanied by other diseases
or had low immunity, the pneumonia was prone to be aggravated.
Low-dose COVID-19 CT Image Denoising Using CNN and its Method
Noise Thresholding
Authors: Singh Prabhishek , Diwakar Manoj , Pandey Neeraj Kumar , Singh Ravinder , Sisodia Dilip , Arya Chandrakala , Chakraborty Chinmay 
Published: April 2022

Abstract:
Noise in computed tomography (CT) images may occur due to low radiation doses. Hence,
the main aim of this paper is to reduce the noise from low-dose CT images so that the risk of high radiation
dose can be reduced.

Background:
The novel coronavirus outbreak has ushered in different new areas of research in medical
instrumentation and technology. Medical diagnostics and imaging are one of the ways in which the
area and level of infection can be detected.

Objective:
COVID-19 attacks people with less immunity, so infants, kids, and pregnant women are
more vulnerable to the infection. So, they need to undergo CT scanning to find the infection level. But
the high radiation diagnostic is also fatal for them, so the intensity of radiation needs to be reduced
significantly, which may generate the noise in the CT images.

Method:
This paper introduces a new denoising technique for low-dose Covid-19 CT images using a
convolution neural network (CNN) and noise-based thresholding method. The major concern of the
methodology for reducing the risk associated with radiation while diagnosing.

Results:
The results are evaluated visually and using standard performance metrics. From comparative
analysis, it was observed that proposed works give better outcomes.

Conclusions:
The proposed low-dose COVID-19 CT image denoising model is therefore concluded to
have a better potential to be effective in various pragmatic medical image processing applications in
noise suppression and clinical edge preservation.
Phenolic Compounds and Antioxidant and Antimicrobial Activities of
Pulicaria Odora Extract
Authors: Saidani Karima , Touati Naima , Merzouk Hafida , Boussaa Halim , Bedjou Fatiha , Oomah B. Dave 
Published: April 2022

Background:
Asteraceae family, of which Pulicaria genus, plays a remarkable role in the development of drugs used in modern medicine. Leaf extracts of Pulicaria odora harvested in Bejaia were evaluated for their antioxidant and antimicrobial activities.

Methods:
HCl method at three different wavelengths 280, 320 and 360 nm was carried out for total phenolics content and characterized by ultra-performance liquid chromatography (UPLC) analysis. Antimicrobial activity was evaluated using four bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Listeria innocua) and three molds (Aspergillus flavus, Aspergillus niger and Trichoderma reesei). Four antioxidant tests (ORAC, ABTS, DPPH and FRAP) were performed.

Results:
The extracts had high total polyphenols (305 mg catechin equivalents [CE]), flavonols (56 mg quercetin equivalents [QE]), tannins (77 mg CE) and tartaric acids (38 mg caffeic acid equivalents [CAE]) per g dry matter contents. UPLC analysis of the 70 % ethanol extracts showed abundant phenolic acids (protocatechuic, chlorogenic and caffeic acids). Pulicaria odora extracts exhibited good antimicrobial activity against bacterial (~18 mm inhibition zones) and molds (11.3-17.3 mm) strains.

Conclusion:
All extracts displayed good antioxidant activity and effective antimicrobial activity, which allow its use as a conservative agent or therapeutic remedy.
Repurposing of Various Current Medicines as Radioprotective Agents
Authors: Kaur Rajwinder , Lang Damanpreet Kaur , Singh Harwinder , Arora Arpita , Garg Nikhil , Saini Balraj 
Published: April 2022

Background:
The side effects of ionising radiation include skin changes, dry mouth, hair loss, low blood
count, and the mutagenic effect on normal cells when utilized in radiotherapy for cancer treatment. These radiations
can cause damage to the cell membrane, lipids, proteins, and DNA and generate free radicals. Evidence reports stated
that radiotherapy accounts for 17-19% of secondary malignancies, labelling this treatment option a double-edged
sword.

Objective:
Radioprotective molecules are used for mitigating radiotherapy's side effects. These agents show free radical
scavenging, antioxidant, collagen synthesis inhibition, protease inhibition, immune stimulation, increased cytokine
production, electron transfer, and toxicity reduction properties. The most frequently used amifostine has an array of
cancer applications, showing multitarget action as nephroprotective to cisplatin and reducing the chances of xerostomia.
Many other agents, such as metformin, edaravone, mercaptopropionylglycine, in specific diseases, such as diabetes,
cerebral infarction, cystinuria, have shown radioprotective action. This article will discuss potentially repurposed
radioprotectors that can be used in the clinical setting, along with a brief discussion on specific synthetic agents like
amifostine and PrC-210.

Methods:
Rigorous literature search using various electronic databases, such as PubMed, ScienceDirect, Scopus,
EMBASE, Bentham Science, Cochrane Library, etc., was made. Peer-review research and review papers were selected,
studied, reviewed, and analysed.

Conclusion:
Safety and risk-free treatment can be guaranteed with the repurposed agents. Agents like metformin,
captopril, nifedipine, simvastatin, and various others have shown potent radioprotective action in various studies. This
review compiled repurposed synthetic radioprotective agents.
Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective
Agent
Authors: Joshi Shivanki , Dhingra Ashwani K. , Chopra Bhawna , Guarve Kumar , Bhateja Deepak 
Published: April 2022

Background:
Neuroprotection is preserving neural function in various neurodegenerative
diseases like Alzheimer’s, Huntington’s, Parkinson’s, and multiple sclerosis. Hesperidin, a flavanone
glycoside in citrus fruits such as sweet oranges and lemons, possesses many biological effects, including
neuroprotection.

Objective:
The study aims to explore the neuropharmacological mechanisms and therapeutic potential
of hesperidin in the management of neurodegenerative disorders.

Method:
It emphasizes comparative and clinical trial studies with a number of targets reviewed from
the data available on PubMed, Science Direct, Clinicaltrails.gov, and from many reputed foundations.

Result:
Escalating clinical evidence has established the inhibitory effect of hesperidin in the management
of neurodegenerative disorders. Neuroprotective potential of hesperidin is characterized by
endogenous antioxidant defence functions, improvement of neural growth factors, antineuroinflammatory
activity, and apoptotic pathways.

Conclusion:
The present study highlights the beneficial neuropharmacological potential of hesperidin,
including anticonvulsant, antidepressant, antioxidant, anti-inflammatory, memory, and locomotor enhancing
activities.
Medicinal Importance, Pharmacological Activities and Analytical Aspects
of a Flavonoid Glycoside ‘Nicotiflorin’ in the Medicine
Authors: Patel Dinesh Kumar 
Published: April 2022

Background:
Herbal products are derived from different natural sources, mainly used as
a source of food material and medicine in the health sectors since ancient times. Herbal products
have gained popularity in modern medicine due to their beneficial health properties and pharmacological
activities. Flavonoids are an important class of secondary metabolites found to be present in
medicinal plants and their derived products. Flavonoids have been known for their anti-allergic,
anti-bacterial, anti-diabetic, anti-inflammatory, anti-viral, anti-proliferative, anti-mutagenic, antithrombotic,
anti-carcinogenic, anti-oxidant and hepatoprotective activities in the medicine. Nicotiflorin
is a flavonoidal class phytochemical, found in medicinal plants, including Traditional Chinese
medicine.

Methods:
Scientific data on the medicinal importance and pharmacological activities of nicotiflorin
have been collected and analyzed in the present work in order to know the therapeutic importance
of nicotiflorin in medicine. Scientific data have been collected from Google, Google
Scholar, Science Direct, PubMed and Scopus and analyzed in the present work. Analytical techniques
data of separation, isolation and identification of nicotiflorin have also been collected and
presented in the current work. Further biological importance of flavonoidal class phytochemicals
was also discussed in the present work to understand the biological importance of nicotiflorin in
medicine as it belongs to the flavonoid class.

Results:
Scientific data analysis revealed the therapeutic importance and pharmacological activities
of nicotiflorin. Nicotiflorin has significant biological potential against coronavirus, ischemia,
renal impairment, hepatic complication, memory dysfunction and myocardial infarction. The biological
potential of nicotiflorin against α-glucosidase and α-amylase enzymes, multiple myeloma
cells and insulin secretion has also been discussed in the present work. Analytical data revealed the
significance of modern analytical tools in medicine for the isolation, separation and quantification
of nicotiflorin.

Conclusion:
Scientific data analysis of different research works revealed the biological importance
and therapeutic potential of nicotiflorin in medicine.
Antibacterial and Phagocytic Properties of a Novel Silver-Interferon
Complex
Authors: Plotnikov Evgenii , Plotnikov Vladimir 
Published: April 2022

Background:
Developing new antibacterial and antiviral drugs are considered a significant issue due to the emergence and spread of resistant strains of microorganisms. The COVID-19 pandemic has dramatically increased the need for new broad-spectrum anti-infective agents.

Objective:
This experimental study aimed to investigate the antibacterial and phagocytic properties of silver-interferon preparation. The combination of properties of complex drugs makes them promising for treating drug-resistant infections and bacterial complications of viral diseases.

Method:
The antibacterial effect of the silver-interferon platform was investigated by agar diffusion and serial dilution methods. The drug's effect on the functional activity of phagocytes was studied on human neutrophils in a Staphylococcus aureus uptake test.

Results:
Investigations have shown that the silver-interferon complex possesses a bactericidal mechanism of action against tested bacterial strains, including Streptococcus pneumonia, Salmonella enteritidis, Staphylococcus aureus, Escherichia coli. Streptococcus pneumonia was the most susceptible bacterial target for the tested complex, with a growth inhibition zone of 12±0.6 mm and a minimal bactericidal concentration of 0.08 mg/ml. A slight stimulating action of the drug in relation to the activity of phagocytes was revealed.

Conclusion:
Silver-interferon has proved as a prospective anti-infective drug with a wide range of activities.
A Educação Profissional e Tecnológica na vida e visão de uma educadora: Marise Nogueira Ramos
Authors: Urbanetz Sandra Terezinha , Romanowski Joana Paulin , Tedesco Filho Jacir Mario 
Published: April 2022

O processo da historicidade da Educação Profissional e Tecnológica e da relação entre Educação e Trabalho é tão caro e fundamental para aquelas e aqueles que se debruçam sobre o tema, em que se apresentam importantes desafios e oportunidades para as/os profissionais da educação, tendo em vista que o avanço tecnológico contemporâneo tem exigido novas competências relacionadas aos processos formativos nesta modalidade.Nesse sentido, é fundamental para esta discussão não somente questões teóricas, mas, também, questões pragmáticas para o desenvolvimento do tema nos mais variados lugares em que essa discussão possa ocorrer: seja no acadêmico, na agenda das políticas públicas e na sociedade como um todo.É nesse contexto, utilizando uma prática da História oral, que a presente edição da revista Retratos da Escola traz uma conversa com Marise Nogueira Ramos, professora associada da Faculdade de Educação da UERJ e credenciada no quadro permanente dos Programas de Pós-Graduação em Políticas Públicas e Formação Humana, da UERJ e de Educação Profissional em Saúde, da Escola Politécnica de Saúde Joaquim Venâncio, da FIOCRUZ.Como dizem, a vida não cabe no Lattes, por isso, a escolha da professora Marise se deu em função de suas produções e pesquisas na área da Educação Profissional, onde se pode notar um cuidado extremo com os processos formativos e a defesa da classe trabalhadora, com seus direitos. E foi nesse ponto que buscamos alcançar, em uma conversa em que a professora contasse sua história de vida e como as questões da Educação Profissional perpassaram e ainda perpassam sua história no seu processo de formação profissional, nos ambientes acadêmico e institucional.No decorrer de sua narrativa, percebemos a grandeza dessa mulher, trabalhadora, filha de operários, que identifica claramente as marcas históricas, tanto familiares quanto sociais, como constituintes de sua pessoa. Com essa identificação ela nos ensina conceitos fundamentais para se pensar uma outra escola, uma outra sociedade...E nos devolve a esperança, não a esperança ingênua, mas a esperança da luta e da certeza de que estamos do lado certo da história!