bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletal muscle-derived exosomal miR-146a-5p inhibits lipogenesis by mediating muscle-fat axis and targeting GDF5-PPARγsignaling
Authors: Qin Mengran , Xing Lipeng , Wu Jiahan , Wen Shulei , Luo Jun-Yi , Sun Jiajie , Chen Ting , Fan Yaotian , Zhu Jiahao , Yang Lekai , Liu Jie , Xiong Jiali , Chen Xingping , Zhu Canjun , Wang Songbo , Wang Lina , Shu Gang , Jiang Qingyan , Zhang Yong-Liang , Xi Qian-Yun 
Published: September 2022

AbstractSkeletal muscle-Fat interaction is essential for maintaining organismal energy homeostasis and managing obesity by secreting cytokines and exosomes, but the role of the latter as new mediator in the inter-tissue communication still remains unclear. Recently, we discovered that miR-146a-5p was mainly enriched in skeletal muscle-derived exosomes (SKM-Exos), more 50-fold higher than fat exosomes. Here, we investigated the role of skeletal muscle-derived exosome regulating lipid metabolism in adipose tissue by delivering miR-146a-5p. The results showed that exosomes from skeletal myoblast significantly inhibited the differentiation of preadipocytes and its adipogenesis. When the skeletal muscle-derived exosomes co-treated adipocytes with miR-146a-5p inhibitor, this inhibition was reversed. Additionally, skeletal muscle-specific knockout miR-146a-5p (mKO) significantly increased body weight gain and decreased oxidative metabolism in mice. Whereas the internalization of this miRNA into the mKO mice by injecting skeletal muscle-derived exosomes from the Flox mice (Flox-Exos) resulted in the significant phenotypic reversion, including down-regulation of genes and proteins involved in fat synthesis. Mechanistically, miR-146a-5p has also been demonstrated to function as a negative regulator of peroxisome proliferator-activated receptor γ (PPARγ) signaling by directly targeting growth and differentiation factor 5 (GDF5) gene to mediate fat synthesis and fatty acid absorption. Taken together, these data provide new insights into the role of miR-146a-5p as a novel myokine involved in the regulation of lipogenesis and obesity via mediating the skeletal muscle-fat signaling axis, and may serve as a target for the development of therapies against various metabolic diseases, including obesity, lipodystrophy and insulin resistance.
Eavesdropping on competing condensates by the edge supercurrent in a Weyl superconductor.
Authors: Kim Stephan , Lei Shiming , Schoop Leslie , Cava Robert , Ong N. Phuan 
Published: September 2022

Abstract
In a topological insulator the metallic surface states are easily distinguished from the insulating bulk states [1]. By contrast, in a topological superconductor [2-5], much less is known about the relationship between an edge supercurrent and the bulk pair condensate. Can we force their pairing symmetries to be incompatible?
In the superconducting state of the Weyl semimetal MoTe$_2$, an edge supercurrent is observed as oscillations in the current-voltage (\emph{I-V}) curves induced by fluxoid quantization [6]. We have found that the $s$-wave pair field of supercurrent injected from niobium contacts is incompatible with the intrinsic pair condensate in MoTe$_2$. The incompatibility leads to strong stochasticity in the switching current $I_c$ as well as other anomalous properties such as an unusual antihysteretic behavior with the ``wrong'' sign. Under the injected supercurrent, the fluxoid-induced edge oscillations survive to much higher magnetic fields \emph{H}. Interestingly, the oscillations are either very noisy or noise-free depending on the pair field that ends up dictating the edge pairing. Using the phase noise as a sensitive probe that eavesdrops on the competiting bulk states, we uncover an underlying blockade mechanism whereby the intrinsic condensate can pre-emptively block proximitization by the Nb pair field depending on the history.
For Which Children with ADHD is TBR Neurofeedback Effective? Comorbidity as a Moderator
Authors: Roley-Roberts Michelle E. , Pan Xueliang , Bergman Rachel , Tan Yubo , Hendrix Kyle , deBeus Roger , Kerson Cynthia , Arns Martijn , Jehli Nadja R. Ging , Connor Shea , Shrader Constance , Arnold L. Eugene 
Published: September 2022

Abstract
Introduction: We examined psychiatric comorbidities moderation of a 2-site double-blind randomized clinical trial of theta/beta-ratio (TBR) neurofeedback (NF) for attention deficit hyperactivity disorder (ADHD).
Methods:Seven-to-ten-year-olds with ADHD received either NF (n=84) or Control (n=58) for 38 treatments. Outcome was change in parent-/teacher-rated inattention from baseline to end-of-treatment (acute effect), and 13-month-follow-up. Seventy percent had at least one comorbidity: oppositional defiant disorder (ODD) (50%), specific phobias (27%), generalized anxiety (23%), separation anxiety (16%). Comorbidities were grouped into anxiety alone (20%), ODD alone (23%), neither (30%), or both (27%).
Results: Comorbidity (p=0.043) moderated acute effect; those with anxiety-alone responded better to Control than to TBR NF (d=-0.79, CI -1.55- -0.04), and the other groups showed a slightly better response to TBR NF than to Control (d=0.22~0.31, CI -0.3-0.98). At 13-months, ODD-alone group responded better to NF than Control (d=0.74, CI 0.05-1.43).
Discussion: TBR NF is not indicated for ADHD with comorbid anxiety but may benefit ADHD with ODD.
The efficacy of entrepreneurial networking and innovation in fostering the performance of small businesses: A global south perspective
Authors: Sendawula Kasimu , Kisubi Moses Kisame , Najjinda Shamirah , Nantale Hanifah , Kabbera Samuel 
Published: September 2022

Abstract
The purpose of this study was to investigate the efficacy of entrepreneurial networking and innovation in fostering the performance of small businesses using evidence from the global south. The study was cross-sectional and correlational. Data was collected through a self-administered questionnaire survey of 368 small businesses and analyzed through correlation, hierarchical regression and mediation analysis using statistical package for social sciences (SPSS). study findings indicate that entrepreneurial networking and innovation are significant predictors of small business performance. Results also indicate that innovation partially mediates the relationship between entrepreneurial networking and performance of small businesses. As such, this study contributes to the extant literature on the performance of small businesses as it provides initial empirical evidence on the efficacy of entrepreneurial networking and innovation in fostering the performance of small businesses, it further contributes to the recent literature on the mediation effect of innovation using evidence from the global south.
Development and validation of immersive hand rehabilitation system using a VR rhythm game with vibrotactile feedback: an fNIRS pilot study
Authors: Bae Sungjin , Park Hyung-Soon 
Published: September 2022

Abstract
Background
Recently, virtual reality (VR) has been widely utilized with rehabilitation to promote user engagement, which has been shown to induce brain plasticity. In particular, contact-free hand tracking technology has been developed as a control input for VR, and there is an increasing demand for patient-specific hand rehabilitation strategies. In this study, we developed a VR-based hand rehabilitation system consisting of a user-specific gesture-controlled rhythm game with vibrotactile feedback and validated the system by measuring brain activation using functional near-infrared spectroscopy (fNIRS).
Methods
The VR-based hand rehabilitation system provides vibrotactile feedback as the user matches their hand gestures to VR targets customized to their pre-recorded hand gestures that approach according to the rhythm of the music. Cortical activation was measured via fNIRS during 420 seconds of alternating gameplay and rest in 11 healthy subjects and one chronic stroke survivor. Regions of interest (ROI) were the prefrontal cortex (PFC), the premotor cortex & the supplementary motor area (PMC&SMA), the primary sensorimotor cortex (SM1), and the somatosensory association cortex (SAC).
Results
The mean success rate of gesture matching among healthy subjects was 90% with a standard deviation of 10.7%, and the success rate of the stroke survivor was 79.6%. The oxygenated hemoglobin (HbO) cortical activation maps showed that the hemodynamic responses of HbO increased during the VR-based hand rehabilitation for all ROIs for both groups. Paired t-test analysis showed a significant increase in HbO activation values in 23 out of 51 channels that correspond to all ROIs except the left PFC and PMC&SMA, which showed high subject variability.
Conclusion
The experimental results indicate that the proposed gesture-controlled VR rhythm game and vibrotactile feedback system successfully activated brain cortical areas related to motor planning and execution, multisensory, and attention. The proposed system is expected to be effective in promoting brain plasticity by inducing brain activation in key areas for stroke rehabilitation.
Phenotypic Transition of Vascular Smooth Muscle Cells Induced by Endothelial TIE2 Mutations in Venous Malformations
Authors: Du Zhong , You Yuan He , Tian Zhuo Wei , Xu Gui Song , Wang Li Zhen , Zheng Jia Wei , Xiao Meng , He Jie , Wang Yan An 
Published: September 2022

Abstract
Venous malformations (VMs) are congenital vascular malformations characterized by a chronically enlarged and malformed venous cavity. Although TIE2 mutation has been commonly recognized as a vital genetic landscape in VMs, the role of TIE2 in regulating the contraction function of smooth muscle cells remains unclear. We generated mouse models through endothelial germline/somatic expression of Tie2-R848W, which has been identified as a typical mutation in autosomal inherited venous malformations, multiple cutaneous and mucosal venous malformation (VMCM). Tie2-R848Wfl/fl;Tie2Cre+ mice develop pulmonary vascular malformations with internal hemorrhage. Tie2-R848W in Tie2-R848Wfl/fl;AplnER+ mice induces postnatal retinal vascular malformations. Accordingly, we demonstrate that dysregulated function and phenotypic transition of vascular smooth muscle cells (VSMCs) may be the pathogenic basis of Tie2-related vascular malformations. The phenotypic transition of VSMCs was further identified in human VMs of the head and neck carrying TIE2 mutations and in an in vitro model. Downregulated ion transmembrane transport and TNFSF10 may play a substantial role in initiating the phenotypic transition process of VSMCs. In conclusion, germline/somatic TIE2 mutation in ECs might induce an abnormal regulatory relationship between ECs and VSMCs, which is highly associated with the phenotypic transition of VSMCs. Weakened contractility and abnormal proliferation induce a chronic expansion cavity and thickening of the muscle layer, which may develop into venous malformation.
Solving Last-Mile Delivery Challenges is Critical to Increase COVID-19 Vaccine Uptake: A Cluster Randomized Controlled Trial
Authors: Mobarak Ahmed Mushfiq , Meriggi Niccolò , Voors Maarten , Levine Madison , Ramakrishna Vasudha , Kangbai Desmond Maada , Rozelle Michael , Tyler Ella , Cundy Sarah 
Published: September 2022

Abstract
In the first six months of COVID-19 vaccine distribution, over 90% of all doses were given to residents of high and upper middle income nations. Less than 30% of Africans were vaccinated with at least one shot even 18 months after vaccine development. This has led to an explosion of scholarly and policy interest on vaccine hesitancy and ways to overcome it. We argue instead that the limiting factor for many rural Africans is lack of access, and implemented an intervention designed to overcome the logistical challenges of last-mile delivery. The cluster randomized controlled trial in 150 remote rural communities shows that simply bringing vaccines to villages using mobile vaccination teams increases the community vaccination rate by 20 percentage points within just 48-72 hours. Moreover, auxiliary populations showed up at our temporary clinic to get vaccinated, which lowers the cost of this intervention to US$ 32 per person vaccinated. This is more cost-effective than most vaccination strategies investigated via trials.
Effects of transportation on physiological indices and metabolomics of the large yellow croaker Larimichthys crocea
Authors: Zhou Yangchen , Yin Xiaolong , Li Weiye , Gao Yang , Chu Zhangjie 
Published: September 2022

Abstract
Adverse conditions have seriously affected the survival rate of the large yellow croaker (Larimichthys crocea) and the molecular response mechanism needs to be revealed. The aim of this study was to improve the survival rate and alleviate the oxidative stress response of the large yellow croaker during live transport. The experiment involved using different concentrations of MS-222. The transport of live animals is associated with various stressors. After a preliminary experiment, we used an untargeted LC–MS-based metabolomics technique combined with liver biochemical indices assays to examine the changes in L. crocea after 48 h of simulated transport. The results of liver biochemical indices indicated inhibition of gluconeogenesis and pentose phosphate pathway metabolism. In addition, metabolomics analysis identified significantly differentially expressed metabolites between 10 mg/L (T1) and control (C) groups. Furthermore, KEGG results revealed that the pathways of amino acid metabolism, especially the lysine, aspartate and homoserine in the liver were significantly affected. In conclusion, the combination of metabolomics and liver biochemical assays provided a characterization of the response mechanism of L. crocea exposed to simulated transport.
Characteristics and Dating of Brine in Paleo-Salt Lakes of the Western Qaidam Basin
Authors: Li Hongpu , Pan Tong , Jin Fang , Chen Jinniu , Guo Ruirui , Tong YongJun 
Published: September 2022

Abstract
The brine in paleo-salt lakes in the Qaidam Basin is a very important resource of potassium and lithium salts. There has been little research on the formation mechanism of the brine according to noble gases and their isotopic characteristics, let alone research on the formation age of the brine. For this reason, this paper studies the formation mechanism and formation age of the brine in paleo-salt lakes in the Qaidam Basin according to the test data of the samples of noble gas elements and their isotopes collected in the latest deep boreholes in the Qaidam Basin. In the study area, the He content in the brine ranges from 12.2×10− 6 to 1,326.9×10− 6, the Ne content from 1.253×10− 6 to 19.1×10− 6, and the Ar content from 3,046.5×10− 6 to 5,023.1×10− 6; the ratio of 3He/4He ranges from 2.00 ×10− 8 to 2.30×10− 7, R/Ra from 0.01 to 0.16Ra, 20Ne/22Ne from 9.2 to 10.6, 21Ne/22Ne from 0.024 to 0.032, and 40Ar/36Ar from 298.7 to 352. In combination with the correlations between 20Ne/22Ne and 21Ne/22Ne, and 3He/4He and 40Ar/36Ar, and in accordance with the special physical properties of noble gases He, Ne, and Ar (such as lower solubility in groundwater and higher solubility with the increase of ion radius), the following can be inferred: The brine in paleo-salt lakes in the Qaidam Basin has two sources: deep crust and atmospheric precipitation; the reservoirs of the brine in paleo-salt lakes in the Qaidam Basin are Quaternary - Paleogene strata; the brine was formed from Triassic to Ordovician, earlier than the reservoir age according to the calculation of 3He/4He in the brine based on the age accumulation effect.
Asymmetric modulation of winter mixed layer depth induced by mesoscale eddies alongside the Kuroshio Extension jet
Authors: Shi Fei , Luo Yiyong 
Published: September 2022

Abstract
Ocean mesoscale eddies are observed to influence mixed layer depth (MLD) with a deepening by anticyclonic eddies (AEs) and a shoaling by cyclonic eddies (CEs). By using Argo profiles, satellite altimeter data and eddy-resolving model data, this study investigates how the AEs and CEs alongside the Kuroshio Extension jet (KEJ) modulate the winter MLD. Results show that although the modulations by the AEs and CEs are roughly symmetric over the whole region on the winter MLD, their impacts are strongly asymmetric to the north and south of the KEJ. The deepening effect by the AEs is much more than the shoaling effect by the CEs to the north of the KEJ, while the shoaling effect by the CEs is much more than the deepening effect by the AEs to the south of the KEJ. Therefore, their overall effect results in a net deepening to the north and a net shoaling to the south of the KEJ. A further analysis finds that this asymmetric feature is closely related to the distribution of eddy amplitudes which implies more energetic AEs to the north but CEs to the south of the KEJ. This study highlights the importance of the distribution of energetic eddies on the modulation of MLD.
Identifying xenocrystic tourmaline in Himalayan leucogranites
Authors: Han Jinsheng , Chen Huayong , Xu Haijun , Nadeau Olivier , Xu Chang 
Published: September 2022

Abstract
Tourmaline is a common autocrystic mineral in granitic and pegmatitic rocks that records valuable information on the physicochemical evolution of magmas. However, xenocrystic tourmaline that does not crystallize from host magmas is also common but seldom reported and notoriously difficult to identify. Here, autocrystic (Tur G) and xenocrystic (Tur P) tourmalines are identified in two-mica granites and granitic pegmatites from the Cuonadong leucogranites, eastern Himalaya. Electron backscatter diffraction (EBSD), coupled with electron-probe micro-analysis (EPMA) and laser ablation ICP-MS analyses (LA-ICP-MS), is used to discriminate xenocrystic from autocrystic tourmaline. Although both tourmalines have slightly different chemical compositions, the differences are insufficient to permit unambiguous discrimination. However, EBSD systematically shows complex intra-crystalline orientations and deformation xenocrystic grains, and undeformed crystal lattices are predominant in autocrystic grains. EBSD could be a useful tool to identify the origin of tourmaline in granitic rocks, particularly when geochemical analyses and/or geochronological measurements are inconclusive.
Adsorption of brilliant green dye by used-tea-powder: equilibrium, kinetics and thermodynamics studies
Authors: Vithalkar Sarika , Jugade R. M. , Saravanan D. 
Published: September 2022

Abstract
The present research is based on the removal of Brilliant Green (BG) dye from its aqueous solution. Used-tea-powder (UTP) was used as a potential adsorbent to remove BG from aqueous solution. Pore morphology, surface properties, crystalline nature and thermal stability of UTP were assessed by using SEM, FTIR, XRD and TGA analysis. The optimized working conditions were found to be pH 6, UTP dose 100 mg, adsorption time 60 min and BG concentration 100 mg L−1. The qmax obtained from the Langmuir model was 101.01 mg g−1 showing the utility of UTP in dye removal. The breakthrough volume and efficiency of the column were evaluated through column adsorption studies in fixed-bed mode. It was found that the pseudo-second-order kinetics model was followed as evaluated by the correlation studies. The calculated thermodynamic parameters showed that the adsorption process was feasible, exothermic and spontaneous.
The anti-biofilm activity of hydrogen peroxide against Escherichia coli strain FL-Tbz isolated from a pharmaceutical water system
Authors: Farjami Afsaneh , Jalilzadeh Sina , Siahi-Shadbad Mohammadreza , Lotfipour Farzaneh 
Published: September 2022

Abstract
Biofilms are considered a significant reason for the failure of disinfection strategies in industrial water systems due to their resistance to antimicrobial agents. This study is designed to investigate the anti-biofilm activity of hydrogen peroxide (H2O2) at combinations of temperatures and contact times. For this purpose, an in vitro microtiter plate (MTP)-based model system was used for biofilm formation using Escherichia coli (E. coli) strain FL-Tbz isolated from the water system of a pharmaceutical plant. To investigate the anti-biofilm activity of H2O2, it was added at different concentrations (2–7% v/v) to biofilms and incubated at different temperatures (20–60 °C) for 10–40 min to find effective conditions to eradicate biofilms. Maximum biofilms were formed when bacterial suspensions were incubated at 37 °C for 96 h. The rate of biofilm formation using an environmental isolate was higher than that of standard strain. H2O2 at concentrations of ≥6.25% (v/v) at temperatures of ≥40 °C incubated for ≥25 min significantly eradicated the biofilms.
Identification of Acanthamoeba spp. from water and soil of public parks in the north of Iran
Authors: Mahmoudi M. R. , Maleki M. , Zebardast N. , Rahmati B. , Ashrafi K. , Sharifdini M. , Karanis Panagiotis 
Published: September 2022

Abstract
Acanthamoeba, a free-living and opportunistic protozoan parasite, is a causative agent of severe human infections of the cornea and brain. The present study evaluated the distribution and genotyping of Acanthamoeba spp. in water and soil of recreational places in various areas in Guilan province in northern Iran. Eighty water and 20 soil samples were collected from the study area. Water samples were vacuum filtered through a 0.45 μm pore-size membrane filter. Soil samples were washed with sterile distilled water, and washings were similarly filtered, as mentioned for water samples. The filtered material was cultured on non-nutrient agar plates seeded with heat-killed Escherichia coli. Molecular analysis was performed by PCR and sequencing using specific primers for Acanthamoeba. Finally, 26 isolates were successfully sequenced. According to culture and PCR methods, 54% of water and 100% of soil samples were contaminated with Acanthamoeba. Based on the sequencing data, genotypes T4 (47%), T5 (35.29%), T3 (11.76%), and T11 (5.88%) were identified in water samples. Genotypes T4 (66.6%), T5 (22.2%) and T15 (11.1%) were identified in water samples. Most isolates might present a potential health hazard for humans in this region. To the best of our knowledge, this is the first comprehensive survey of water and soil of recreational areas in northern Iran and the first report on identifying genotype T15 from soil sources.