bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of polyamide thin film composite membranes incorporated silver nanoparticles
Authors: Ngo Thu Hong Anh , Pham Hien Thanh , Nguyen Vuong Duy , Duong Quan Xuan , Le Phuong Duy Tu , Do Nguyen Hanh , Dao Duc Sy 
Published: September 2022

AbstractIn this study, the polyamide thin film composite membrane surface has been modified by anti‐microbial silver nanoparticles (AgNPs). The membrane surfaces were interwoven with AgNPs by ultraviolet grafting polymerization method using AgNPs with or without poly(ethylene glycol) (PEG). The membrane surface characteristics were determined by scanning electron microscopy–energy dispersive x‐ray spectrometry images, attenuated total reflection–Fourier transforms infrared spectroscopy, water contact angle values, and anti‐bacterial property. The separation performance was determined based on the flux and the ability to remove calcium ions in water. The anti‐biofouling property was appraised through the maintained flux ratios and the irreversible fouling factors of unmodified and modified membranes during 10 h‐filtration of protein bovine serum albumin (BSA) in an aqueous solution, in which, before filtration of BSA, all membranes were immersed in E. coli bacteria solution for 4 days. The results of the experiments corroborated the hydrophilicity and more anti‐microbial property of the membrane surfaces after being incorporated into AgNPs. The water contact angle decreased from around 49° for the unmodified membrane to 36° and 23° for the AgNP‐modified membranes without/with PEG, while no colonies appeared in the medium containing the AgNP‐modified membranes. The separation property of modified membranes was improved, with both membrane flux and antifouling properties, along with the substantial surge of the anti‐biofouling property. After 10 h of BSA filtration, the fluxes of the modified membranes were maintained at 68% and 78% for AgNP‐modified membranes without and with PEG, respectively. Conversely, this value was only 46% for the unmodified one.
Effect of the surroundings on the photophysical properties of CsPbBr3 perovskite quantum dots embedded in SiOx matrices
Authors: Lee Soo Jeong , Lee You Jeong , Seo Sumi , Jo Hyeonyeong , Han Donghoon , Yoon Seog Joon 
Published: September 2022

AbstractOrganometallic lead halide perovskites have been studied extensively owing to their excellent photophysical properties and have been successfully applied to solar‐driven chemistry and optoelectronic devices. Dimensionally confined perovskite quantum dots (PQDs) have demonstrated outstanding photoluminescence quantum yields, detailed band gap tunability, wide color gamut, and favorable radiative recombination processes. These characteristics expand the versatility of PQDs. Various efforts have been made to increase their stability. The introduction of a core–shell structure increased the stability of PQDs, and they were successfully applied to light‐emitting diodes. Recently, our group demonstrated the potential of PQDs to promote photocatalytic degradation of carcinogens. However, further studies on the detailed interactions between PQDs and their surroundings are necessary to utilize them in practice. This study investigated the impact of surrounding solvents on the material/photophysical properties of PQDs and statistically observed the photoinduced charge transfer from PQDs to transparent conducting oxides. The findings of this study could be used to advance solar‐driven chemistry and optoelectronic devices and to promote the utilization of PQDs in renewable energy applications.
Asciminib vs bosutinib in CML patients pretreated with ≥2 tyrosine kinase inhibitors: Results from the Japanese subgroup analysis of ASCEMBL study
Authors: Yuda Junichiro , Doki Noriko , Matsuoka Hiroshi , Yokota Takafumi , Tomita Akihiro , Takahashi Naoto , Matsumura Itaru , Kubo Kohmei , Goto Tatsunori , Kirito Keita , Maki Akio , Aoki Makoto , Allepuz Alex , Minami Yosuke 
Published: September 2022

AbstractAsciminib, a first‐in‐class, allosteric inhibitor of BCR‐ABL1 that acts by STAMP (Specifically Targeting the ABL Myristoyl Pocket), is a novel therapeutic option for patients with chronic myeloid leukemia (CML). In the global, phase 3, open‐label ASCEMBL study in patients with CML in chronic phase (CML‐CP) pretreated with ≥2 tyrosine kinase inhibitors (TKIs) (NCT03106779), asciminib (40 mg twice‐daily) demonstrated significant superiority over the ATP‐competitive TKI bosutinib (500 mg once daily) for the primary endpoint of major molecular response (MMR; BCR::ABL1 transcript levels on the international scale [BCR::ABL1IS] ≤0.1%) at week 24. Here, we report results from a descriptive subgroup analysis of Japanese patients enrolled in ASCEMBL study (data cut‐off: May 25, 2020). Overall, 16 Japanese patients were randomized (asciminib, n = 13; bosutinib, n = 3). At week 24, the MMR rate with asciminib was 30.8% (4/13; 95% confidence interval [CI], 9.09–61.43). BCR::ABL1IS ≤1% and complete cytogenic response (CCyR) at week 24 were 61.5% (8/13 patients) and 50.0% (4/8 patients), respectively. In the bosutinib group, no patient achieved MMR, CCyR, or BCR::ABL1IS ≤1%, but results were limited by the low number of patients. The safety profile of asciminib was comparable to that previously observed in the overall study population. Findings from this Japanese subgroup analysis of the ASCEMBL study support the use of asciminib for the treatment of Japanese patients with CML‐CP previously treated with ≥2 TKIs. ClinicalTrials.gov Identifier: NCT03106779.
Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence
Authors: Li Jili , Bi Zhengyan , Wang Linlin , Xia Yinghao , Xie Yuqi , Liu Yanlan 
Published: September 2022

AbstractCellular senescence is a stable cell cycle arrest state that can be triggered by a wide range of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is thought to contribute to aging and age‐related diseases. Thus, the detection and interventions of senescent cells are critical for longevity and treatment of disease. However, the highly heterogeneous feature of senescence makes it challenging for precise detection and selective clearance of senescent cells in different age‐related diseases. To address this issue, considerable efforts have been devoted to developing senescence‐targeting molecular theranostic strategies, based on the potential biomarkers of cellular senescence. Herein, we review recent advances in the field of anti‐senescence research and highlight the specific visualization and elimination of senescent cells. Additionally, the challenges in this emerging field are outlined.
Chemoselective Labeling and Immobilization of Phosphopeptides with Phosphorimidazolide Reagents
Authors: Brown Nathaniel W. , Schlomach Sandra K. , Marmelstein Alan M. , Fiedler Dorothea 
Published: September 2022

AbstractProtein phosphorylation is one of the most ubiquitous post‐translational modifications, regulating numerous essential processes in cells. Accordingly, the large‐scale annotation of phosphorylation sites continues to provide central insight into the regulation of signaling networks. The global analysis of the phosphoproteome typically relies on mass spectrometry analysis of phosphopeptides, with an enrichment step necessary due to the sub‐stoichiometric nature of phosphorylation. Several affinity‐based methods and chemical modification strategies have been developed to date, but the choice of enrichment method can have a considerable impact on the results. Here, we show that a biotinylated, photo‐cleavable phosphorimidazolide reagent permits the immobilization and subsequent cleavage of phosphopeptides. The method is capable of the capture and release of phosphopeptides of varying characteristics, and this mild and selective strategy expands the current repertoire for phosphopeptide chemical modification with the potential to enrich and identify new phosphorylation sites in the future.
Rapid Access to Chiral and Tripodal Cavitands from β‐Pinene
Authors: Wang Xiuze , Pavlović Radoslav Z. , Finnegan Tyler J. , Karmakar Pratik , Moore Curtis E. , Badjić Jovica D. 
Published: September 2022

AbstractWe report Pd‐catalyzed cyclotrimerization of (+)‐α‐bromoenone, obtained from monoterpene β‐pinene, into an enantiopure cyclotrimer. This C3 symmetric compound has three bicyclo[3.1.1]heptane rings fused to its central benzene with each ring carrying a carbonyl group. The cyclotrimer undergoes diastereoselective threefold alkynylation with the lithium salts of five terminal alkynes (41–63 %, de=4–83 %). The addition enabled a rapid synthesis of a small library of novel chiral cavitands that, in shape, resemble a tripod stand. These molecular tripods include a tris‐bicycloannelated benzene head attached to three alkyne legs twisted in one direction to form a nonpolar cavity with polar groups as feet. Tripods with methylpyridinium and methylisoquinolinium legs, respectively, form inclusion complexes with anti‐inflammatory and chiral drugs (R)/(S)‐ibuprofen and (R)/(S)‐naproxen. The mode of binding shows drug molecules docked in the cavity of the host through ion‐ion, cation‐π, and C−H−π contacts that, in addition of desolvation, give rise to complexes having millimolar to micromolar stability in water. Our findings open the door to creating a myriad of enantiopure tripods with tunable functions that, in the future, might give novel chemosensors, catalysts or sequestering agents.
Molecular Engineering of Push‐Pull Diphenylsulfone Derivatives towards Aggregation‐Induced Narrowband Deep Blue Thermally Activated Delayed Fluorescence (TADF) Emitters
Authors: Xia Yan , Li Jie , Chen Xu , Li Anran , Guo Kunpeng , Chen Fei , Zhao Bo , Chen Zhikuan , Wang Hua 
Published: September 2022

AbstractNarrowband deep blue thermally activated delayed fluorescent (TADF) materials have attracted significant attention. Herein, four asymmetrical structured TADF emitters based on diphenylsulfone (DPS) acceptor and 9,9‐dimethyl‐9,10‐dihydroacridine (DMAC) donor with progressive performances were developed. The tert‐butyloxy auxiliary electron‐donor was adopted to restrict the intramolecular rotations and provide efficient steric hindrance. Regioisomerization by altering the substitution position of DMAC on DPS unit further enhanced the intra‐ and inter‐molecular interactions. The accompanying effects yielded increased energy level, minimized reorganization energy, and inhibited non‐radiative transitions in the crystals of tBuO‐SOmAD, which achieved narrowband deep‐blue emission peaking at 424 nm (FWHM=64 nm, ΦF=33.6 %) through aggregation‐induced, blue‐shifted emission (AIBSE). In addition, deep‐blue organic light emitting diodes (OLEDs) based on tBuO‐SOmAD realized the electroluminescence (EL) spectrum peaking located at 435 nm and CIE coordination of (0.12, 0.09).
Analysis of QoS aware energy‐efficient resource provisioning techniques in cloud computing
Authors: Malla Parvaz Ahmad , Sheikh Sophiya 
Published: September 2022

SummaryBy incorporating on‐demand resources, software and data for collaborative services through the Internet, the conventional Information Technology enterprise has been transformed by cloud computing. Based on the pay‐per‐use approach, Infrastructure, platform or Software resources and servers located across data centres are among the several types of resources offered to consumers in cloud computing. Data centres handle these resources. These resources are constantly provisioned to users based on their availability, demand, and quality requirements. Cloud computing systems are known as one of the largest utilisers of energy resources all over the world. Also, power consumption has become a crucial aspect as most cloud computing systems work on traditional nonrenewable resources of energy. In order to make data centres environment‐friendly, there is a need for optimal approaches to reduce energy consumption and their hazardous effects on the environment. To analyse different available strategies for building and maintaining an energy‐efficient cloud is the main objective of this paper. The paper will comprehensively review several energy‐efficient resource provisioning methods and provide a graphical comparative study of Quality of Service (QoS) Metrics in cloud computing. Moreover, the present study identifies the areas of study that need to be further improved to increase the energy efficiency of cloud computing systems.
Multisensory representations of space and time in sensory cortices
Authors: Gori Monica , Bertonati Giorgia , Campus Claudio , Amadeo Maria Bianca 
Published: September 2022

AbstractClear evidence demonstrated a supramodal organization of sensory cortices with multisensory processing occurring even at early stages of information encoding. Within this context, early recruitment of sensory areas is necessary for the development of fine domain‐specific (i.e., spatial or temporal) skills regardless of the sensory modality involved, with auditory areas playing a crucial role in temporal processing and visual areas in spatial processing. Given the domain‐specificity and the multisensory nature of sensory areas, in this study, we hypothesized that preferential domains of representation (i.e., space and time) of visual and auditory cortices are also evident in the early processing of multisensory information. Thus, we measured the event‐related potential (ERP) responses of 16 participants while performing multisensory spatial and temporal bisection tasks. Audiovisual stimuli occurred at three different spatial positions and time lags and participants had to evaluate whether the second stimulus was spatially (spatial bisection task) or temporally (temporal bisection task) farther from the first or third audiovisual stimulus. As predicted, the second audiovisual stimulus of both spatial and temporal bisection tasks elicited an early ERP response (time window 50–90 ms) in visual and auditory regions. However, this early ERP component was more substantial in the occipital areas during the spatial bisection task, and in the temporal regions during the temporal bisection task. Overall, these results confirmed the domain specificity of visual and auditory cortices and revealed that this aspect selectively modulates also the cortical activity in response to multisensory stimuli.
Anode interfacial modification for non‐fullerene polymer solar cells: Recent advances and prospects
Authors: Ahmad Nafees , Liang Guangxing , Fan Ping , Zhou Huiqiong 
Published: September 2022

AbstractRecently, the power conversion efficiency (PCE) of single‐junction non‐fullerene polymer solar cells (NF‐PSCs) has surpassed 19% due to the fast development of novel donor polymers, NF‐acceptors, device engineering, and interlayer materials. The anode interlayer (AIL) plays a vital role in improving the efficiency and stability of PSCs. The challenges and opportunities in this research area encourage researchers to pursue great innovation in developing new materials and strategies for highly efficient NF‐PSCs. This review summarizes the recent development of AIL materials and their modification strategies in single‐junction NF‐PSCs. Firstly, a brief introduction, key functions, basic requirements, and peculiar features of AILs when employed in NF‐PSCs are discussed. Then, the impact of AIL materials (including organic, inorganic, and hybrid materials) on the PCE and the stability of NF‐PSCs are described. Afterward, the fabrication of large‐area devices and related issues are highlighted. The summary and the future challenges regarding efficient AIL are summarized in the last section of this review.image
Umbelliferone protects against methylglyoxal‐induced HUVECs dysfunction through suppression of apoptosis and oxidative stress
Authors: Zhang Shunxiao , Zhang Sheng , Li Yuan‐Yuan , Zhang Yan , Wang Hua , Chen Yue , Sun Mingyu 
Published: September 2022

AbstractMethylglyoxal (MGO), a cytotoxic metabolite of glycolysis, can cause endothelial cells impairment, which is tightly associated with diabetic vascular complication. Umbelliferone, a derivative of coumarin, participates in various pharmacological activities. This study aimed to determine the effectiveness of umbelliferone in MGO‐induced apoptosis and oxidative stress in endothelial cells. In this study, it has been indicated that umbelliferone inhibited MGO‐induced human umbilical vein endothelial cells (HUVECs) cytotoxicity, apoptosis, Bax/Bcl‐2 protein ratio, the activity of cleaved‐caspase‐3, and mitochondrial membrane potential loss. Furthermore, we found that umbelliferone inhibited MGO‐induced activation of mitogen‐activated protein kinases and nuclear factor‐κB signaling pathways in HUVECs. In addition, umbelliferone could suppress oxidative stress, as evidenced by decrease of reactive oxygen species and malondialdehyde (MDA) generation, and increase of superoxide dismutase and glutathione peroxidase contents. Moreover, we found that umbelliferone can activate Nrf2/HO‐1 signaling. Importantly, silencing of Nrf2 signaling clearly eliminated the anti‐oxidative stress of umbelliferone, whereas umbelliferone pretreatment had no effect on Nrf2 overexpressing HUVECs. Altogether, this study suggested that umbelliferone pretreatment has a protective effect on MGO‐induced endothelial cell dysfunction through inhibiting apoptosis and oxidative stress.
“Battling something bigger than me”: A phenomenological investigation of generational trauma in African American women
Authors: Petion Ashlei R. , Chang Catherine Y. , Brown‐Thompson Crystal , Mitchell Michelle D. , Grinnage Deaetta , Huffstead Mary E. 
Published: September 2022

AbstractThe lived experiences of eight African American women college students were explored from an interpretive phenomenological analytic framework. The researchers identified six main themes about participants and their reported family dynamics: (a) collectivistic yet disconnected, (b) avoidance, (c) functioning in dysfunction, (d) gendered differences, (e) motivation to change the family's homeostasis, and (f) talking about generational trauma as a motivator to repair communication. Implications for culturally responsive counseling and generational trauma‐informed counselor training are discussed.
Childhood psychological maltreatment, sense of self, and PTSD symptoms in emerging adulthood
Authors: Watts Justin R. , Lazzareschi Nicholas R. , Liu Yanhong , O'Sullivan Deirdre 
Published: September 2022

AbstractThis study outlines the relationships among childhood psychological maltreatment (CPM), an understudied form of maltreatment, sense of self (SOS), a developmental construct negatively impacted by trauma, and post‐traumatic stress disorder (PTSD) symptoms in emerging adults. Results from regression analysis on a sample of emerging adults (N = 358) indicated CPM to be the greatest predictor of a weaker SOS, even when considered alongside other types of child maltreatment. Among those exposed to CPM, SOS was a significant predictor of PTSD symptoms, explaining 34.1% of the variance in the outcome. Counseling interventions that focus on SOS during emerging adulthood are recommended as one important consideration for survivors of CPM who experience PTSD symptoms. Specific counseling practice and research implications are included.
Benchmark of density functional theory methods for the study of organic polysulfides
Authors: Sharma Jyoti , Champagne Pier Alexandre 
Published: September 2022

AbstractElemental sulfur is often used in organic synthesis as its low cost and high abundance make it a highly desirable source of sulfur atoms. However, sulfur's unpredictable catenation behavior poses challenges to its widespread usage due to difficulties in designing new reactions that can account for its multifaceted reactivity. In order to accurately model sulfur's mechanisms using computational approaches, it is necessary to identify density functional theory (DFT) methods that are accurate on these systems. This study benchmarks 12 well‐known DFT functionals that include local, non‐local, and hybrid methods against DLPNO‐CCSD(T)/aug‐cc‐pV(Q+d)Z//MP2/aug‐cc‐pV(T+d)Z/SMD(MeCN) for the accurate treatment of organic polysulfides, taking cyanide as a nucleophile. Our benchmarking results indicate that the M06‐2X and B3LYP‐D3(BJ) density functionals are the most accurate for calculating reaction energies, while local functionals performed the worst. For activation energies, MN15, MN15‐L, M06‐2X, and ωB97X‐D are the most accurate. Our analysis of structural parameters shows that all functionals perform well for ground state optimizations except B97D3, while MN15‐L and M06‐2X performed best for transition structure optimizations. Overall, the four hybrid functionals MN15, M06‐2X, ωB97X‐D, and B3LYP‐D3(BJ) appear adequate for studying the reaction mechanisms of polysulfides.
Effect of ZrS2 load single/dual‐atom catalysts on the hydrogen evolution reaction: A first‐principles study
Authors: Dong Shizhi , Li Yanshuai , Hu Hongyu , Li Ruichuan , Yan Bing , Zhang Xing , Wang Zeliang , Zhang Jinyu , Guo Lin 
Published: September 2022

AbstractThe hydrogen evolution effect of ZrS2 carrier loaded with transition metal single‐atom (SA) was explored by first‐principles method. ZrS2 was constructed with transition metal single‐atom and dual‐atom. The structure–activity relationship of supported single‐atom catalysts was described by electronic properties and hydrogen evolution kinetics. The results show that the ZrS2 carrier‐loaded atomic‐level catalysts are more likely to occur in acidic environments, where the Mo SA load has a higher hydrogen precipitation capacity than the Pt SA. In the case of dual‐atom adsorption, most of the hydrogen reduction processes are higher than that of single atom loading, which indicates that the outer orbital hybridization is more likely to lead to the interfacial charge recombination of the catalyst. Thereinto, Ni/Pt @ZrS2 has the lowest Gibbs free energy (0.08 eV), and the synergistic effect of transition metals induces the deviation of the center of the d‐band from the Fermi level and improves the dissociation ability of H ions. The design provides a new catalytic model for the HER and provides some ideas for understanding the two‐site catalysis.
Cervical length screening for predicting preterm birth: A comparative review of guidelines
Authors: Impis Oglou Mechmet , Tsakiridis Ioannis , Mamopoulos Apostolos , Kalogiannidis Ioannis , Athanasiadis Apostolos , Dagklis Themistoklis 
Published: September 2022

AbstractA cervical length (CL) assessment may predict preterm birth (PTB). This study aimed to analyze and compare the recommendations of guidelines on the role of CL in the prediction of PTB. There is no consensus regarding universal screening of asymptomatic women without a history of prior spontaneous PTB (sPTB), using CL. On the other hand, CL assessment is recommended in cases with a history of sPTB due to the high recurrence rate. Finally, there is discrepancy regarding CL assessment in asymptomatic women with multiple pregnancy. Although far from perfect, CL measurement remains the best available method to predict PTB.