bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large volume was associated with increased risk of acute non-hematologic adverse events in the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer: preliminary results of prospective phase I/II clinical trial
Authors: Murakami Naoya , Watanabe Miho , Uno Takashi , Sekii Shuhei , Tsujino Kayoko , Kasamatsu Takahiro , Machitori Yumiko , Aoshika Tomomi , Kato Shingo , Hirowatari Hisako , Kaneyasu Yuko , Nakagawa Tomio , Ikushima Hitoshi , Ando Ken , Murata Masumi , Yoshida Ken , Yoshioka Hiroto , Murata Kazutoshi , Ohno Tatsuya , Okonogi Noriyuki , Saito Anneyuko , Ichikawa Mayumi , Okuda Takahito , Tsuchida Keisuke , Sakurai Hideyuki , Yoshimura Ryouichi , Yoshioka Yasuo , Yorozu Atsunori , Okamoto Horoyuki , Inaba Koji , Kato Tomoyasu , Igaki Hiroshi , Itami Jun 
Published: April 2022

Abstract

Objective
This is the preliminary results of a multi-center prospective clinical trial evaluating the feasibility of the hybrid of intracavitary and interstitial brachytherapy for locally advanced cervical cancer.

Methods
Patients with FIGO stage IB2, IIA2, IIB, IIIA, IIIB and IVA uterine cervical cancer pretreatment width of which was ≥5 cm measured by MRI were eligible. Protocol therapy consisted of 30–30.6 Gy in 15–17 fractions of whole pelvic radiotherapy concurrent with weekly CDDP, followed by 24 Gy in 4 fractions of hybrid of intracavitary and interstitial and pelvic radiotherapy with central shield up to 50–50.4 Gy in 25–28 fractions. The primary endpoint of phase I part was that the rate of grade ≥ 3 acute non-hematologic adverse events related to hybrid of intracavitary and interstitial would be &lt;10%.

Results
Between October 2015 and October 2019, 74 patients underwent primary registration, with 52 patients eventually proceeding to the secondary registration. The median pretreatment tumor width was 5.7 cm, and FIGO Stages were IB2 10, IIA2 2, IIB 20 and IIIB 20, respectively. The median high-risk clinical target volume D90 was 72.0 Gy (54.8–86.6 Gy, EQD2), rectum D2cc was 53.7 Gy (29.3–80.3 Gy) and bladder D2cc was 69.8 Gy (38.9–84.8 Gy). The rate of grade ≥ 3 non-hematologic adverse events related to hybrid of intracavitary and interstitial was 1.9% (1/52), and 17.3% (9/52) of patients experienced non-hematologic adverse events related to hybrid of intracavitary and interstitial of any grade. In multivariate analysis, high-risk clinical target volume ≥ 35 ml was associated with an increased risk of any grade of acute non-hematologic adverse events related to hybrid of intracavitary and interstitial (P = 0.036).

Conclusion
The feasibility and reproducibility of hybrid of intracavitary and interstitial were demonstrated from a multi-center prospective clinical trial.
Croup Associated With SARS-CoV-2: Pediatric Laryngotracheitis During the Omicron Surge
Authors: Sharma Sujit , Agha Beesan , Delgado Carlos , Walson Karen , Woods Charles , Gonzalez Mark D , Jerris Robert , Sysyn Gregory , Beiter James , Kamidani Satoshi , Rostad Christina A 
Published: April 2022

Abstract
In this retrospective analysis, we describe weekly croup and corresponding viral prevalence patterns in a pediatric quaternary care system in metropolitan Atlanta. We characterize a series of 24 patients with croup associated with SARS-CoV-2 infection and show that this clinical presentation increased substantially in frequency during the period of high Omicron vs Delta transmission.
Development and dosimetric verification of 3D customized bolus in head and neck radiotherapy
Authors: Chatchumnan Nichakan , Kingkaew Sakda , Aumnate Chuanchom , Sanghangthum Taweap 
Published: April 2022

Abstract
The commercial flat bolus cannot form perfect contact with the irregular surface of the patient’s skin, resulting in an air gap. The purpose of this study was to evaluate the feasibility of using a 3D customized bolus from silicone rubber. The silicone rubber boluses were studied in basic characteristics. The 3D customized bolus was fabricated at the nose, cheek and neck regions. The point dose and planar dose differences were evaluated by comparing with virtual bolus. The hardness, thickness, density, Hounsfield unit (HU) and dose attenuation of the customized bolus were quite similar to a commercial bolus. When a 3D customized bolus was placed on the RANDO phantom, it can significantly increase buildup region doses and perfectly fit against the irregular surface shape. The average point dose differences of 3D customized bolus were −1.1%, while the commercial bolus plans showed −1.7%. The average gamma results for planar dose differences comparison of 3D customized bolus were 93.9%, while the commercial bolus plans were reduced to 91.9%. Overall, A silicone rubber bolus produced the feasible dosimetric properties and could save cost compared to a commercial bolus. The 3D printed customized bolus is a good buildup material and could potentially replace and improve treatment efficiency.
Dosimetric effect of set-up error in accelerator-based boron neutron capture therapy for head and neck cancer
Authors: Komori Shinya , Hirose Katsumi , Sato Mariko , Takeuchi Akihiko , Kato Ryohei , Motoyanagi Tomoaki , Harada Takaomi , Yamazaki Yuhei , Harada Mayumi , Narita Yuki , Kato Takahiro , Takai Yoshihiro 
Published: April 2022

Abstract
The dosimetric effect of set-up error in boron neutron capture therapy (BNCT) for head and neck cancer remains unclear. In this study, we analyzed the tendency of dose error by treatment location when simulating the set-up error of patients. We also determined the tolerance level of the set-up error in BNCT for head and neck cancer. As a method, the distal direction was shifted with an interval of 2.5 mm, from 0.0 mm to +20.0 mm and compared with the dose at the reference position. Similarly, the horizontal direction and vertical direction were shifted, with an interval of 5.0 mm, from −20.0 mm to +20.0 mm. In addition, cases with 3.0 mm and 5.0 mm simultaneous shifts in all directions were analyzed as the worst-case scenario. The dose metrics of the minimum dose of the tumor and the maximum dose of the mucosa were evaluated. From unidirectional set-up error analysis, in most cases, the set-up errors with dose errors within ±5% were Δdistal &lt; +2.5 mm, Δhorizontal &lt; ±5.0 mm and Δvertical &lt; ±5.0 mm. In the simulation of 3.0 mm shifts in all directions, the errors in the minimum tumor dose and maximum mucosal dose were −3.6% ±1.4% (range, −5.4% to −0.6%) and 2% ±1.4% (range, 0.4% to 4.5%), respectively. From these results, if the set-up error was within ±3.0 mm in each direction, the dose errors of the tumor and mucosa could be suppressed within approximately ±5%, which is suggested as a tolerance level.
Adamantinoma of tibia: excision and reconstruction with free vascularized fibula flap: a case report and review of literature
Authors: Sahu Shamendra Anand , Mishra Jiten Kumar , Kar Bikram Keshari , Manju R , De Moumita 
Published: April 2022

Abstract
Adamantinoma is a rare malignant tumour usually affecting the diaphysis of long bones. The tumour most commonly affects the tibia. Conventional management involves excision with a wide margin, reconstruction and sometimes amputation. Multiple options are available, but reconstruction depends upon the size of the bony defect and available resources. None has proved to be the favourable one. We have analysed the advantages and shortcomings of various methods used. In our case, a 33-year-old male patient presented with a large adamantinoma of the midtibial region of the left leg, which was managed with excision and reconstruction of long segment bony defect with free vascularized osteocutaneous fibula flap. There are osseointegration and hypertrophy of the vascularized bone with good functional gain in long term follow-up. Autologous bone reconstruction after adamantinoma excision with microvascular free fibula flap in large bone segment defects salvage the limb with satisfactory functional outcome.
Deep venous thrombosis in a 41-year-old female with May–Thurner syndrome following abdominoplasty and medial thigh lift
Authors: Bombardelli Joao , Kaplan Jordan , Doval Andres F , Rappaport Norman H 
Published: April 2022

Abstract
Deep venous thrombosis (DVT) is a feared occurrence following body contouring surgery as it can result in pulmonary embolism. Acute presentation can range from lower extremity edema and pain to being totally asymptomatic. Surgical literature reports reveal many risk factors for developing DVT, and surgeons must risk stratify their patients to best prevent this outcome. However, there are conditions which place patients at risk that are difficult to account for when making such decisions as they can be undiagnosed and are not a part of standard screening protocols. We present a case of DVT in a 41-year-old female with undiagnosed May–Thurner syndrome following abdominoplasty and medial thigh lift for massive weight loss. The authors discuss the current literature as well as challenges faced by surgeons who strive to appropriately risk stratify their cosmetic surgery patients to avoid complications such as venous thromboembolism.
Cytoreductive surgery for giant locally advanced intra-abdominal tumors in Uganda
Authors: Okello Michael , Nuwagaba Julius , Ddungu Henry , Okuku Fred Machyo 
Published: April 2022

Abstract
Cytoreductive surgery is removal of tumor as much as possible when complete resection is impossible because of advanced disease. It is a management option for giant intra-abdominal tumors with pressure symptoms. We present three patients who underwent cytoreductive surgery for giant intra-abdominal tumors between May 2019 and November 2021. Patient 1 had a gastrointestinal stromal tumor (GIST) involving stomach, spleen and transverse colon. En bloc resection of the GIST with the involved viscera was done. Patient 2 had a liposarcoma measuring 25.8 × 19.6 × 15.3 cm infiltrating the stomach, spleen and the left hemidiaphragm. Involved viscera and liposarcoma were resected en bloc. Patient 3 had a liposarcoma measuring 40 × 35 × 12 cm and encasing the left ureter. Mass was excised together with part of the left ureter and left ureter reconstructed. Giant intra-abdominal tumors are rare. Involvement of adjacent structures may necessitate multivisceral resections with or without organ reconstruction.
Excision of large right atrial myxoma through a right mini thoracotomy
Authors: Henmi Soichiro , Salica Andrea , Scaffa Raffaele , D’Aleo Salvatore , Wolf Lorenzo Guerrieri , De Paulis Ruggero 
Published: April 2022

Abstract
Cardiac myxoma is the most common primary benign cardiac tumor in adults and right atrial myxoma is a rare observation. We report a case of a 56-year-old woman who presented with dyspnea and diagnosed with a right atrial myxoma. Urgent operation through a right mini thoracotomy was done and myxoma was completely excised. Traditionally, median sternotomy with cardiopulmonary bypass is used for excision of cardiac myxoma. Excision through a mini thoracotomy for patients with right atrial myxoma appear to be safe, feasible and efficacious.
Data Privacy Concerns as a Source of Resistance to Complete Mobile Data Collection Tasks Via a Smartphone App
Authors: Roberts Caroline , Herzing Jessica M E , Sobrino Piazza Jimena , Abbet Philip , Gatica-Perez Daniel 
Published: April 2022

AbstractSmartphones present many interesting opportunities for survey research, particularly through the use of mobile data collection applications (apps). There is still much to learn, however, about how to integrate apps in general population surveys. Recent studies investigating hypothetical willingness to complete mobile data collection tasks via an app suggest there may be substantial resistance, in particular, due to concerns around data privacy. There is not much evidence about how privacy concerns influence actual decisions to participate in app-based surveys. Theoretical approaches to understanding privacy concerns and survey participation decisions would suggest that the influence of the former over the latter is likely to vary situationally. In this paper, we present results from a methodological experiment conducted in the context of a three-wave probability-based online panel survey of the general population as part of the 2019 Swiss Election Study (“Selects”) testing different ways of recruiting participants to an app. Questions included at wave 1 about online data privacy concerns and comfort sharing different types of data with academic researchers allow us to assess their impact on both hypothetical willingness to download a survey app for completing questionnaires, to take and share photos, and to share the smartphone’s GPS location and actual completion of these tasks. Our findings confirm that general concerns about online data privacy do influence hypothetical willingness to complete mobile data collection tasks, but may be overridden by how comfortable people feel about sharing specific types of data with researchers. When it comes to actual compliance with task requests, however, neither privacy concerns nor comfort sharing data seem to matter. We conclude with recommendations for exploring these relationships further in future app-based studies.
Compliance with the Current NCCN Guidelines and Its Critical Role in Pancreatic Adenocarcinoma
Authors: Petersen Jeffrey M , Jhala Darshana N 
Published: April 2022

Abstract

Objectives
Since 2019, the National Comprehensive Cancer Network (NCCN) has recommended genetic testing for patients diagnosed with pancreatic adenocarcinoma that includes universal germline testing and tumor gene profiling for metastatic, locally advanced, or recurrent disease. However, testing compliance with this guideline has not yet been published in the English literature.

Methods
A quality assurance/quality improvement retrospective review was done to identify patients diagnosed with pancreatic adenocarcinoma from January 2019 to February 2021 to include the patient’s clinical status and genetic test results.

Results
There were 20 patient cases identified with pancreatic adenocarcinoma. A total of 11 cases had molecular tumor gene profiling and microsatellite instability/mismatch repair (MSI/MMR) testing performed and 1 case had only MSI/MMR testing by immunohistochemistry performed. Only 3 patients of the 20 in total received germline testing.

Conclusion
There was a significant number of patients for whom tumor gene profiling or germline testing had never been attempted as per recommended NCCN guidelines.
LERA—an interactive platform for synoptical representations of multiple text witnesses
Authors: Pöckelmann Marcus , Medek André , Ritter Jörg , Molitor Paul 
Published: April 2022

AbstractIn the humanities, text comparison is essential for scholarly editing the traditions of a text with its different witnesses under study. For the computer-aided creation of a critical apparatus, there have been established approaches and tools for many years. However, they mainly focus on subsentences or sentences. An efficient and easy-to-use automatic comparison of entire chapters or books still represents a research desideratum. The Locate, Explore, Retrace and Apprehend complex text variants (LERA) working environment presented here solves this issue. It is based on a two-stage collation approach: an efficient, fully automatic alignment of text segments, which can be paragraphs, subparagraphs or sentences, with interactive post-processing options, followed by the detailed comparison at segment level. Because aligning text segments, such as paragraphs, for more than two text witnesses is algorithmically challenging, we discuss the heuristics we developed in more detail. LERA combines the entire process of document management, tokenization/segmentation, normalization, alignment, and visualization with interactive control options and exploratory tools. It has already been and is being successfully applied in several Digital Humanities projects of different languages, e.g. for Arabic, French, Hebrew as well as German and English texts.
Immigrant legalization: A dilemma between justice and the rule of law
Authors: Song Sarah , Bloemraad Irene 
Published: April 2022

AbstractImmigrant legalization policies pose an ethical dilemma between justice and the rule of law. On the one hand, liberal democracies aspire to the principles of individual liberty and equality. Building on liberal ideals of justice, compelling arguments have been made for granting legal status and a path to citizenship to unauthorized migrants by virtue of the social ties they have developed, their contributions to the host society, and their vulnerability to exploitation. On the other hand, legalization poses a challenge to another important value, the rule of law, which requires government to operate within a framework of law in accordance with well-established public norms. Immigrant legalization programmes are said to undermine the rule of law because they reward lawbreaking, allow queue-jumping, and incentivize further unauthorized migration. This article clarifies each horn of the dilemma, focusing on rule of law arguments. We offer a critical reappraisal of immigrant legalization policies by reflecting on the normative meaning of the rule of law and by examining empirical evidence assessing the effects of legalization. Our central contention is that legalization policies can enhance the rule of law. We offer five rule of law arguments in support of legalization, which help to mitigate the dilemma between justice and the rule of law. We conclude by discussing some policy implications of our analysis.
Excellence in Exile: Jewish Exceptionalism in Anti-Zionist Thought
Authors: Kimche J J 
Published: April 2022

Abstract
This essay seeks to illuminate an understudied strain of modern Jewish political thought, which is here termed ‘exceptionalist anti-Zionism’. Thinkers of this diverse school strongly subscribe to some form of Jewish exceptionalism and believe that it is precisely this exceptional nature that obviates or undermines the necessity for a Jewish state. This essay presents three versions of this intellectual strain through an analysis of one important thinker who exemplifies each version. Samson Raphael Hirsch offers a religious form of exceptionalist anti-nationalism, in which the divine mission of the Jewish nation requires its perpetual dispersion throughout the world’s civilizations. Franz Rosenzweig offers a philosophical form of exceptionalist anti-Zionism, in which the Jewish nation inhabits an entirely distinct temporal plane that precludes the traditional attributes of national life. George Steiner offers an ethical form of exceptionalist anti-Zionism, in which the Jews’ ethical superiority depends on their status as the perpetually itinerant ‘guests’ of every human society, and therefore naturally rejects any coalescence of national self-identity. These three thinkers, despite their irreducible differences, constitute an important counter-voice within a political discourse that generally conflates nationhood and nationalism, and present an alternative vision for a Jewish diasporic existence.
Autonomy and Radical Evil: Kant’s Ethical Transformation of Sin
Authors: Dalferth Ingolf U 
Published: April 2022

Abstract
The paper examines Kant’s idea of autonomy as well as his conception of radical evil against the background of the theological tradition relevant to him. It is shown that both of them can be understood as ethical secularizations of theological concepts—the freedom of God and the concept of original sin—and that in both cases the problems of the theological tradition reoccur.
Multimodal synchrotron X-ray fluorescence imaging reveals elemental distribution in seeds and seedlings of the Zn–Cd–Ni hyperaccumulatorNoccaea caerulescens
Authors: van der Ent Antony , de Jonge Martin D , Echevarria Guillaume , Aarts Mark G M , Mesjasz-Przybyłowicz Jolanta , Przybyłowicz Wojciech J , Brueckner Dennis , Harris Hugh H 
Published: April 2022

AbstractThe molecular biology and genetics of the Ni–Cd–Zn hyperaccumulator Noccaea caerulescens has been extensively studied, but no information is yet available on Ni and Zn redistribution and mobilization during seed germination. Due to the different physiological functions of these elements, and their associated transporter pathways, we expected differential tissue distribution and different modes of translocation of Ni and Zn during germination. This study used synchrotron X-ray fluorescence tomography techniques as well as planar elemental X-ray imaging to elucidate elemental (re)distribution at various stages of the germination process in contrasting accessions of N. caerulescens. The results show that Ni and Zn are both located primarily in the cotyledons of the emerging seedlings and Ni is highest in the ultramafic accessions (up to 0.15 wt%), whereas Zn is highest in the calamine accession (up to 600 μg g–1). The distribution of Ni and Zn in seeds was very similar, and neither element was translocated during germination. The Fe maps were especially useful to obtain spatial reference within the seeds, as it clearly marked the vasculature. This study shows how a multimodal combination of synchrotron techniques can be used to obtain powerful insights about the metal distribution in physically intact seeds and seedlings.
Clinical Profile of Monomicrobial Corynebacterium Hip and Knee Periprosthetic Joint Infections
Authors: Tabaja Hussam , Tai Don Bambino Geno , Beam Elena , Abdel Matthew P , Tande Aaron J 
Published: April 2022

Abstract

Background
Corynebacterium periprosthetic joint infection (PJI) is a poorly described infectious syndrome. Prior studies included cases of polymicrobial infections. This series describes the clinical characteristics, management, and outcomes of monomicrobial Corynebacterium PJI.

Methods
We queried the Mayo Clinic Total Joint Registry for cases of monomicrobial Corynebacterium knee and hip PJI in adults (age ≥18 years) between 2010 and 2019.

Results
A total of 20 (1%) out of 2067 PJI cases met our inclusion criteria. Most were males (55%), and the median age was 64 years. Seventy percent had chronic symptoms (&gt;4 weeks). PJI was delayed to late (&gt;3 months postimplantation) in 90%. Three species were identified: C. striatum (70%), C. jeikeium (20%), and C. amycolatum (10%). All tested isolates were susceptible to vancomycin (100%) and linezolid (100%), and most had a minimum inhibitory concentration ≤0.06 mcg/mL to daptomycin (75%). Other agents were less reliable, with high resistance to oral agents commonly used for suppression. Nineteen patients were treated: 37% debridement and implant retention (DAIR), 47% 2-stage exchange, and 16% resection without reimplantation. Of these, failure occurred in 29%, 11%, and 0%, respectively.

Conclusions
Corynebacterium PJIs pose a therapeutic challenge due to limited antimicrobial armamentarium and undefined optimal surgical intervention. Vancomycin and linezolid remain the most reliable agents for treatment. DAIR may be attempted for acute PJI, but verification of durable chronic suppression options will be critical for this approach.
Outcomes of B-Cell-Depleted Patients With Coronavirus Disease 2019 Treated With Antispike Monoclonal Antibodies
Authors: Yetmar Zachary A , Khodadadi Ryan B , Seville Maria Teresa , Brumble Lisa , O’Horo John C , Ganesh Ravindra , Razonable Raymund R 
Published: April 2022

Abstract
Antispike monoclonal antibody treatment of 180 B-cell-depleted patients with mild-to-moderate coronavirus disease 2019 (COVID-19) resulted in good outcomes overall, with only 12.2% progressing to severe disease, 9.4% requiring hospitalization, 0.6% requiring mechanical ventilation, no deaths within 30 days, and 1.8% developing persistent COVID-19. Antispike monoclonal antibodies appear effective in this immunocompromised population.