bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two substellar survivor candidates: one found and one missing
Authors: Walters N , Farihi J , Marsh T R , Breedt E , Cauley P W , von Hippel T , Hermes J J 
Published: December 2022

ABSTRACT
This study presents observations of two possible substellar survivors of post-main sequence engulfment, currently orbiting white dwarf stars. Infrared and optical spectroscopy of GD 1400 reveals a 9.98 h orbital period, where the benchmark brown dwarf has M2 = 68 ± 8 MJup, Teff ≈ 2100 K, and a cooling age under 1 Gyr. A substellar mass in the lower range of allowed values is favoured by the gravitational redshift of the primary. Synthetic brown dwarf spectra are able to reproduce the observed CO bands, but lines below the bandhead are notably overpredicted. The known infrared excess towards PG 0010+281 is consistent with a substellar companion, yet no radial velocity or photometric variability is found despite extensive searches. Three independent stellar mass determinations all suggest enhanced mass-loss associated with binary evolution, where the youngest total age for an isolated star is 7.5 ± 2.5 Gyr. A possible solution to this conundrum is the cannibalization of one or more giant planets, which enhanced mass-loss post-main sequence, but were ultimately destroyed. PG 0010 + 281 is likely orbited by a debris disc that is comfortably exterior to the Roche limit, adding to the growing number of non-canonical discs orbiting white dwarfs. At present, only L-type (brown) dwarfs are known to survive direct engulfment during the post-main sequence, whereas T- and Y-type substellar companions persist at wide separations. These demographics indicate that roughly 50 MJup is required to robustly avoid post-main sequence annihilation, suggesting all closely orbiting giant planets are consumed, which may contribute to mass-loss and magnetic-field generation in white dwarfs and their immediate progenitors.
The two z ∼ 13 galaxy candidates HD1 and HD2 are likely not lensed
Authors: Lee Rui Zhe , Pacucci Fabio , Natarajan Priyamvada , Loeb Abraham 
Published: December 2022

ABSTRACT
The discovery of two ultraviolet (UV)-bright galaxy candidates at z ∼ 13, HD1 and HD2, laid the foundation for a new race to study the early Universe. Previous investigations suggested that they are powered either by a supermassive black hole or by an extreme, transient burst of star formation. Given their uncertain nature, we investigate whether these sources could be lensed by a hitherto undetected, faint foreground galaxy. We find that at the current limiting magnitude with which HD1 and HD2 were imaged, there is only a $7.39{{\ \rm per\ cent}}$ probability they are strongly lensed by spherical deflectors and that the hypothetical lensing galaxy was too faint to be detected. Meanwhile, with the limiting magnitudes of the Hubble Space Telescope (HST) and JWST, the theoretical probability would drop precipitously to 0.058 and $0.0012{{\ \rm per\ cent}}$, respectively. We further find it unlikely that the luminosities of both sources can be accounted for by lensing that produces a single, resolved image with sufficiently high magnification. Alternatively, in the unlikely event that their brightness results from lensing by an elliptical isothermal galaxy, there is a $30.9 {{\ \rm per\ cent}}$ probability that the lensing galaxy is too faint to be observable at the current limiting magnitude. Future HST (JWST) imaging will drop this probability to $0.245 {{\ \rm per\ cent}}$ ($0.0025 {{\ \rm per\ cent}}$). In summary, while deep imaging with HST and JWST is required to discard the lensing hypothesis entirely, it is unlikely that the exceptional luminosity of the two z ∼ 13 sources can be accounted for by gravitational lensing.
Low-redshift quasars in the SDSS Stripe 82 – III. MOS observations
Authors: Bettoni D , Falomo R , Paiano S , Kotilainen J K , Stone M B 
Published: December 2022

ABSTRACT
We present multi-object optical spectroscopy of the galaxies in the environment of 12 low-redshift (z &lt; 0.5) quasars and of 11 inactive massive galaxies chosen to match the properties of the quasar host galaxies to probe physical association and possible events of recent star formation (SF). The quasars are selected from a sample of QSOs in the Sloan Digital Sky Survey (SDSS) Stripe 82 region for which both the host galaxy and the large-scale environments were previously investigated. The new observations complement those reported in our previous works on close companion galaxies of nearby quasars. For the whole data set, we find that for about half (19 out of 44) of the observed QSOs, there is at least one associated companion galaxy. In addition to the new spectroscopic observations, we add data from the SDSS data base for the full sample of objects. We find that the incidence of companion galaxies in the fields of QSO (17 per cent) is not significantly different from that of inactive galaxies (19 per cent) similar to quasar hosts in redshift and mass. Nevertheless, the companions of quasars exhibit more frequently emission lines than those of inactive galaxies, suggesting a moderate link between the nuclear activity and recent SF in their environments.
Super-critical accretion of medium-weight seed black holes in gaseous proto-galactic nuclei
Authors: Sassano Federica , Capelo Pedro R , Mayer Lucio , Schneider Raffaella , Valiante Rosa 
Published: December 2022

ABSTRACT
Accretion at sustained or episodic super-Eddington (SE) rates has been proposed as a pathway to grow efficiently light seeds produced by Pop-III stars. We investigate if SE accretion can be sustained onto a black hole (BH) with MBH ∼ 103 M⊙ in the centre of a gas-rich proto-galaxy at z = 15. We perform high-resolution smoothed-particle hydrodynamical simulations, including two different sub-grid models for SE accretion, one based on the slim disc paradigm, and one inspired by recent radiation-magnetohydrodynamical simulations by Jiang and collaborators. Radiative feedback has the form of a thermal dump to surrounding gas particles, with the radiative efficiency being set according to the different SE accretion models. We find that, in all simulations, star formation, BH feedback, and interactions between clumps and the BH rapidly quench accretion after ∼1 Myr, irrespective of the sub-grid model used for accretion. Quenching is stronger in the model based on the simulations of Jiang and collaborators relative to the slim disc model because of its higher radiative efficiency. The SE growth phase is always very brief, lasting a few 0.1 Myr. In the most optimistic case, the BH reaches a mass of ∼104 M⊙. We extrapolate the final BH masses from z = 15 to z ∼ 6, assuming subsequent galaxy mergers will replenish the gas reservoir and trigger new cycles of SE accretion. We find that at most BH seeds would grow to ∼106 M⊙, comparable to the mass of massive BHs in spiral galaxies such as the Milky Way, but falling short of the mass of the high-redshift quasars.
Observational constraints on maximum mass limit and physical properties of anisotropic strange star models by gravitational decoupling in Einstein–Gauss–Bonnet gravity
Authors: Maurya S K , Singh Ksh Newton , Govender M , Ray Saibal 
Published: December 2022

ABSTRACT
In this work, we are guided by the gravitational wave events GW 170817 and GW 190814 together with observations of neutron stars PSR J1614-2230, PSR J1903+6620, and LMC X-4 to model compact objects within the framework of Einstein–Gauss–Bonnet (EGB) gravity. In addition, we employ the extended gravitational decoupling (EGD) method to explore the impact of anisotropy by varying the decoupling parameter. We model strange quark stars in which the interior stellar fluid obeys the MIT Bag equation of state which represents a degenerated Fermi gas comprising of up, down, and strange quarks. In order to close the system of field equations describing the seed solution, we employ the Buchdahl ansatz for one of the metric functions. The θ sector is solved under the bifurcation: $\epsilon =\theta ^0_0$ and $P_r=\theta ^1_1$ leading to two new families of solutions. In order to test the physical viability of the models, we vary the EGB parameter (α) or the decoupling constant (β) to achieve the observed masses and radii of compact objects. Our models are able to account for low-mass stars for a range of β values while α is fixed. The present models mimic the secondary component of the GW 190814 with a mass range of 2.5–2.67 M⊙ and radii typically of the order of 11.76$^{+0.14}_{-0.19}$ km for large values of the EGB parameter and the decoupling constant. The energy exchange between fluids inside the stellar object is sensitive to model parameters which lead to stable configurations.
Displacement and dissociation of oligonucleotides during DNA hairpin closure under strain
Authors: Ding Fangyuan , Cocco Simona , Raj Saurabh , Manosas Maria , Nguyen Thao Thi Thu , Spiering Michelle M , Bensimon David , Allemand Jean-François , Croquette Vincent 
Published: December 2022

Abstract
The hybridization kinetic of an oligonucleotide to its template is a fundamental step in many biological processes such as replication arrest, CRISPR recognition, DNA sequencing, DNA origami, etc. Although single kinetic descriptions exist for special cases of this problem, there are no simple general prediction schemes. In this work, we have measured experimentally, with no fluorescent labelling, the displacement of an oligonucleotide from its substrate in two situations: one corresponding to oligonucleotide binding/unbinding on ssDNA and one in which the oligonucleotide is displaced by the refolding of a dsDNA fork. In this second situation, the fork is expelling the oligonucleotide thus significantly reducing its residence time. To account for our data in these two situations, we have constructed a mathematical model, based on the known nearest neighbour dinucleotide free energies, and provided a good estimate of the residence times of different oligonucleotides (DNA, RNA, LNA) of various lengths in different experimental conditions (force, temperature, buffer conditions, presence of mismatches, etc.). This study provides a foundation for the dynamics of oligonucleotide displacement, a process of importance in numerous biological and bioengineering contexts.
Smoking Cessation Among Gender Minority Populations, Cis-women, and Cis-men: Findings From the International Tobacco Control Netherlands Survey
Authors: Nagelhout Gera E , Poole Nikita L , Geboers Cloé , Magnée Tessa , Kaag Anne Marije , van den Brand Floor A , van den Putte Bas , de Vries Hein , Fong Geoffrey T , Willemsen Marc C 
Published: December 2022

AbstractIntroductionLittle is known about smoking cessation among gender minority populations compared to cisgender individuals (whose gender matches their sex assigned at birth). We examined differences between smokers from gender minority populations, cis-women, and cis-men in the heaviness of smoking, quit intentions, use of cessation assistance, quit attempts (ever tried and number), and triggers for thinking about quitting.Aims and MethodsWe used cross-sectional data from the 2020 International Tobacco Control Netherlands Survey. Among smoking respondents, we distinguished (1) cis-women (female sex, identified as women, and having feminine gender roles; n = 670), (2) cis-men (male sex, identified as men, and having masculine gender roles; n = 897), and (3) gender minorities (individuals who were intersex, who identified as nonbinary, genderqueer, had a sex/gender identity not listed, whose gender roles were not feminine or masculine, or whose gender identity and/or roles were not congruent with sex assigned at birth; n = 220).ResultsAlthough gender minorities did not differ from cis-women and cis-men in the heaviness of smoking, plans to quit smoking, and quit attempts, they were significantly more likely to use cessation assistance (20% in the past 6 months) than cis-women (12%) and cis-men (9%). Gender minorities were also significantly more likely to report several triggers for thinking about quitting smoking, for example, quit advice from a doctor, an anti-smoking message/campaign, and the availability of a telephone helpline.ConclusionDespite equal levels of quit attempts and heaviness of smoking, gender minority smokers make more use of smoking assistance, and respond stronger to triggers for thinking about quitting smoking.ImplicationsSmoking cessation counselors should be sensitive to the stressors that individuals from any minority population face, such as stigmatization, discrimination, and loneliness, and should educate their smoking clients on effective coping mechanisms to prevent relapse into smoking after they experience these stressors. Developing tailored smoking cessation programs or campaigns specifically for gender minority populations can also be useful. Based on the results of our subgroup analyses, programs or campaigns for younger gender minority smokers could focus on the availability of telephone helplines and on how friends and family think about their smoking behavior.
Efficacy and Safety of Avapritinib in Treating Unresectable or Metastatic Gastrointestinal Stromal Tumors: A Phase I/II, Open-Label, Multicenter Study
Authors: Li Jian , Zhang Xinhua , Deng Yanhong , Wu Xin , Zheng Zhichao , Zhou Yongjian , Cai Shirong , Zhang Yanqiao , Zhang Jun , Tao Kaixiong , Cui Yuehong , Cao Hui , Shen Kuntang , Yu Jiren , Zhou Ye , Ren Wenxiao , Qu Chenglin , Zhao Wanqi , Hu Jin , Wang Wei , Yang Jason , Shen Lin 
Published: December 2022

AbstractBackgroundAvapritinib is a type 1 kinase inhibitor designed to potently and selectively inhibit oncogenic KIT/PDGFRA mutants by targeting the kinase active conformation. This multicenter, single-arm, open-label, phase I/II bridging study of NAVIGATOR in Chinese patients evaluated the safety and the antineoplastic activity of avapritinib in Chinese patients with unresectable/metastatic gastrointestinal stromal tumors (GIST).MethodsPhase I comprised dose escalation for safety and phase II dose determination. Phase II comprised dose expansion for safety/efficacy evaluations in patients with PDGFRA D842V mutations or patients having received at least 3 lines of therapy without PDGFRA D842V mutations. The primary endpoints were recommended phase II dose, safety, and Independent Radiology Review Committee (IRRC)-assessed objective response rate (ORR).ResultsNo dose-limiting toxicities occurred (n = 10); the recommended phase II dose was avapritinib 300 mg once daily orally. Fifty-nine patients initially received avapritinib 300 mg. Common grade ≥3 treatment-related adverse events were anemia, decreased white blood cell count, increased blood bilirubin levels, and decreased neutrophil count. In patients with PDGFRA D842V mutations, IRRC- and investigator-assessed ORRs were 75% and 79%, respectively; clinical benefit rates were both 86%. Median duration of response/progression-free survival were not reached. IRCC- and investigator-assessed ORRs in patients in the fourth- or later-line setting were 22% and 35%, respectively. Median progression-free survivals were 5.6 months for both. Overall survival data were immature and not calculated.ConclusionAvapritinib was generally well tolerated and showed marked anti-tumor activity in Chinese patients with GIST bearing PDGFRA D842V mutations and notable efficacy as fourth- or later-line monotherapy (ClinicalTrials.gov Identifier: NCT04254939).
A close-in planet orbiting giant star HD 167768
Authors: Teng Huan-Yu , Sato Bun’ei , Kunitomo Masanobu , Takarada Takuya , Omiya Masashi , Harakawa Hiroki , Xiao Guang-Yao , Liu Yu-Juan , Izumiura Hideyuki , Kambe Eiji , Yoshida Michitoshi , Itoh Yoichi , Ando Hiroyasu , Kokubo Eiichiro , Ida Shigeru 
Published: December 2022

Abstract
We report the detection of a giant planet orbiting the G-type giant star HD 167768 from radial velocity measurements using the High Dispersion Echelle Spectrograph (HIDES) at Okayama Astrophysical Observatory (OAO). HD 167768 has a mass of $1.08_{-0.12}^{+0.14}\, M_{\odot }$, a radius of $9.70_{-0.25}^{+0.25}\, R_{\odot }$, a metallicity of $[\mbox{Fe}/\mbox{H}]=-0.67_{-0.08}^{+0.09}$, and a surface gravity of $\log g = 2.50_{-0.06}^{+0.06}$. The planet orbiting the star is a warm Jupiter, having a period of $20.6532_{-0.0032}^{+0.0032}\:\mbox{d}$, a minimum mass of $0.85_{-0.11}^{+0.12}\, M_{\rm {J}}$, and an orbital semimajor axis of $0.1512_{-0.0063}^{+0.0058}\:\mbox{au}$. The planet has one of the shortest orbital periods among those ever found around deeply evolved stars (log g &lt; 3.5) using radial velocity methods. The equilibrium temperature of the planet is 1874 K, as high as a hot Jupiter. The radial velocities show two additional regular variations at 41 d and 95 d, suggesting the possibility of outer companions in the system. Follow-up monitoring will enable validation of the periodicity. We also calculated the orbital evolution of HD 167768 b and found that the planet will be engulfed within 0.15 Gyr.
Non-inflammatory pain in inflammatory arthritis
Authors: Das Dhivya , Choy Ernest 
Published: December 2022

Abstract
‘Non-inflammatory’ pain, pain that is not associated with measures of inflammation, is common in patients with inflammatory arthritis including RA. One important cause of non-inflammatory pain is concomitant fibromyalgia. Systematic review has shown that fibromyalgia is common in inflammatory arthritis including RA affecting 1 in 5 patients and is associated with higher disease activity scores due to inflated tender joint count and patient global assessment. Consequently, many patients with RA and concomitant fibromyalgia may fail to reach treatment target and switch to alternate disease modifying drugs frequently. European Alliance of Association for Rheumatology has highlighted that concomitant fibromyalgia is an important consideration in assessing difficult-to-treat RA. The incidence and prevalence of fibromyalgia are higher in RA than the general population, raising the possibility that fibromyalgia may be ‘secondary’ to RA rather than a concomitant disease. The precise mechanisms whereby patients with RA develop fibromyalgia are unknown. In this review, we discussed fibromyalgia in RA, its clinical impact and epidemiology as well as data suggesting fibromyalgia might be ‘secondary’. Lastly, we reviewed potential pathogenic mechanisms which included inflammatory cytokines sensitizing nociceptive neurones, temporal summation, also known as windup, from chronic pain and impaired coping from poor quality sleep and mental well-being. Deciphering the exact mechanisms may lead to treatment strategies that prevent development of secondary fibromyalgia and will address a common factor associated with difficult-to-treat RA.
Associations between evening shift work, irregular sleep timing, and gestational diabetes in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b)
Authors: Wallace Danielle A , Reid Kathryn , Grobman William A , Facco Francesca L , Silver Robert M , Pien Grace W , Louis Judette , Zee Phyllis C , Redline Susan , Sofer Tamar 
Published: December 2022

AbstractStudy ObjectivesShift work is a risk factor for cardiometabolic disease, possibly through effects on sleep–wake rhythms. We hypothesized that evening (afternoon and night combined) and irregular (irregular/on-call or rotating combined) shift work during pregnancy is associated with increased odds of preeclampsia, preterm birth, and gestational diabetes mellitus (GDM), mediated by irregular sleep timing.MethodsThe Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) is a prospective cohort study (n = 10 038) designed to investigate risk factors for adverse pregnancy outcomes. Medical outcomes were determined with medical record abstraction and/or questionnaires; sleep midpoint was measured in a subset of participants with ≥5-day wrist actigraphy (ActiWatch). We estimated the association of evening and irregular shift work during pregnancy with preeclampsia, preterm birth, and GDM using logistic regression, adjusted for adversity (cumulative variable for poverty, education, health insurance, and partner status), smoking, self-reported race/ethnicity, and age. Finally, we explored whether the association between shiftwork and GDM was mediated by variability in sleep timing.ResultsEvening shift work is associated with approximately 75% increased odds of developing GDM (adjusted OR = 1.75, 95% CI: 1.12–2.66); we did not observe associations with irregular shifts, preterm birth, or preeclampsia after adjustment. Pregnant evening shift workers were found to have approximately 45 minutes greater variability in sleep timing compared to day workers (p &lt; .005); sleep-timing variability explained 25% of the association between evening shift work and GDM in a mediation analysis.ConclusionsEvening shift work was associated with GDM, and this relationship may be mediated by variability in sleep timing.
Transient Methionine Deprivation Triggers Histone Modification and Potentiates Differentiation of Induced Pluripotent Stem Cells
Authors: Ozawa Hiroki , Kambe Azusa , Hibi Kodai , Murakami Satoshi , Oikawa Akira , Handa Tetsuya , Fujiki Katsunori , Nakato Ryuichiro , Shirahige Katsuhiko , Kimura Hiroshi , Shiraki Nobuaki , Kume Shoen 
Published: December 2022

AbstractHuman induced pluripotent stem cells (iPSCs) require high levels of methionine (Met). Met deprivation results in a rapid decrease in intracellular S-adenosyl-methionine (SAM), poising human iPSCs for differentiation and leading to the apoptosis of undifferentiated cells. Met deprivation triggers rapid metabolic changes, including SAM, followed by reversible epigenetic modifications. Here, we show that short-term Met deprivation impairs the pluripotency network through epigenetic modification in a 3D suspension culture. The trimethylation of lysine 4 on histone H3 (H3K4me3) was drastically affected compared with other histone modifications. Short-term Met deprivation specifically affects the transcription start site (TSS) region of genes, such as those involved in the transforming growth factor β pathway and cholesterol biosynthetic process, besides key pluripotent genes such as NANOG and POU5F1. The expression levels of these genes decreased, correlating with the loss of H3K4me3 marks. Upon differentiation, Met deprivation triggers the upregulation of various lineage-specific genes, including key definitive endoderm genes, such as GATA6. Upon differentiation, loss of H3K27me3 occurs in many endodermal genes, switching from a bivalent to a monovalent (H3K4me3) state. In conclusion, Met metabolism maintains the pluripotent network with histone marks, and their loss potentiates differentiation.