bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analytical model for designing defect-free sheet metal profiles with height-variable cross sections manufactured by Flexible Roller Beading
Authors: Wang Tianbo , Groche Peter 
Published: May 2022

Abstract
Following the industrial change from mass production towards serial customization flexible technologies are becoming increasingly important. Therefore, the novel forming process “flexible roller beading” (FRB) is developed, which enables the continuous production of sheet metal profiles with customizable variable cross-sectional height and exploits the lightweight potential of profile-based constructions. To guarantee the quality and further processability of the profiles, component defects—primarily sheet wrinkling in the profile flange—must be avoided. The occurrence of wrinkling is affected by various geometric parameters of the targeted profile. This makes an empirical determination of the material-dependent process limits inefficient due to the expensive computational times of numerical simulations and effort of experimental test executions. Therefore, a mathematical model is developed which allows the analytical prediction of the process instabilities causing sheet wrinkling. The presented paper includes the description of the mechanical characteristics of FRB based on numerical and experimental investigations. The predictive analytical model derived from these findings determines the maximum longitudinal compressive stress in the profile flange, which is responsible for the wrinkling formation, based on the relevant geometric characteristics. By the comparison of the calculated occurring longitudinal compressive stress with the material-specific critical stress, sheet wrinkling can be predicted and failure-free profile geometries can be efficiently designed. The generality of the analytical model, independent of the profile geometry, is validated by experimental tests.
Squeezing mind out of metal: combining textual evidence with scientific data for metallurgy in early dynastic China
Authors: Liu Ruiliang , Pollard A. Mark 
Published: May 2022

AbstractSince one of the aims of modern archaeometallurgy is to understand the processes carried out by ancient metalworkers, then ideally, we need to go beyond the traditional sources of evidence for such processes — physical investigation and chemical analysis of the objects themselves, and associated manufacturing debris. In order to understand theintentionalitybehind the decisions taken by these metalworkers (the ‘why’, in addition to the ‘how’), then we need to ‘see the world’ as the metalworkers themselves did. The key issue is how to traverse the gulf between ancient and modern perceptions of the natural world. Using ancient Chinese bronze metalwork as an example, we argue that many interesting glimpses of this world can be drawn from the contemporary and later literary sources. But it is crucial to note that these insights have to be supported by independent evidence, such as scientific data or archaeological information. Once verified, these findings can significantly improve our knowledge of the metaphysical perception of metal in the past and offer a heuristic and powerful tool to interpret the relationship between metallurgy and society. For the Chinese Bronze Age, metallurgy performed a crucial part in the political and ritual world. In particular, the different colours of metal objects provide important indicators of the social hierarchy as evidenced by burial practice.
Analysis of a priority queueing system with the enhanced fairness of servers scheduling
Authors: Lee Seokjun , Dudin Alexander , Dudina Olga , Kim Chesoong 
Published: May 2022

AbstractA multi-server queueing system with two types of customers is analyzed. Both types of customers have own reserved servers and also there is a pool of servers that can be used by both types of customers. Type 1 customers have almost preemptive priority with flexible use of a priority depending on the current number of customers of this type in an infinite buffer. Type 2 customers do not have an input buffer and are lost in cases of absence of available servers upon arrival or expelling (forced termination) from service by Type 1 customers. A multi-dimensional Markov chain, which defines the dynamics of the considered system under the fixed total number of servers, numbers of reserved servers, a pattern of the correlated arriving processes, service rates, and the thresholds defining the mechanism of expelling Type 2 customers from service, is analyzed. A numerical example of solving an optimization problem based on the obtained results is considered. Results can be used for the elaboration of enhanced protocols of servers scheduling in many real-world systems including cognitive radio networks with channels leasing.
Oral Squamous Cell Carcinomas Developing from Oral Lichen Planus: A 5–21 year Retrospective Study
Authors: Sagheb Kawe , Blatt Sebastian , Rahimi-Nedjat Roman-Kia , Lingawi Abdullatif , Schiegnitz Eik , Kumar Vinay V. , Walter Christian , Sagheb Keyvan 
Published: May 2022

Abstract
Background and Aims
There is insufficient data regarding clinical characteristics, relapse rates, as well as lymph node metastasis of squamous cell carcinomas of the oral cavity (OSCC) developing from oral lichen planus (OLP-OSCC). The aim of this retrospective study was to evaluate clinical characteristics, as well as relapse, recurrence and survival rates of OLP-OSCC.

Methods
In a retrospective monocenter analysis, all consecutive patients with an OSCC treated in the time period 1st January 2000–December 31 2016 were reviewed. All patients with OSCC developing from OLP/OLL (oral lichenoid lesions) were identified and analyzed for epidemiological data, risk profile, location of primary tumor, pTNM classification, lymph node metastasis, primary therapy, recurrence, and outcome.

Results
A total of 103 patients (45%♂/ 55%♀) with an average age of 62 ± 14 year were included in this study. At the time of initial diagnosis, 17% (n = 18) of patients had cervical metastases (CM) whereas only 11% (11 patients) displayed advanced tumor sizes (T > 2). T-status (p = 0.003) and histopathological grading (p = 0.001) had an impact on the incidence of CM. 39.6% of the patients developed a relapse after an average of 24 months with a mean of two recurrences per patient. Advanced tumor size had a significant impact on the 5 year overall survival and was associated with disease-free survival of the patients (p < 0.001, respectively p = 0.004).

Conclusion
Although initial lymph node metastases were not more frequent, more aggressive recurrence patterns compared to OSCC were seen for OLP-OSCC. Therefore, based on the study results, a modified recall for these patients is suggested.
Newly identified breast luminal progenitor and gestational stem cell populations likely give rise to HER2-overexpressing and basal-like breast cancers
Authors: McMullen James R. W. , Soto Ubaldo 
Published: May 2022

AbstractBreast Cancer (BrC) is a common malignancy with genetically diverse subtypes. There is evidence that specific BrC subtypes originate from particular normal mammary cell populations. However, the cell populations that give rise to most BrC subtypes are unidentified. Several human breast scRNAseq datasets are available. In this research, we utilized a robust human scRNAseq dataset to identify population-specific marker genes and then identified the expression of these marker genes in specific BrC subtypes. In humans, several BrC subtypes, HER2-enriched, basal-like, and triple-negative (TN), are more common in women who have had children. This observation suggests that cell populations that originate during pregnancy give rise to these BrCs. The current human datasets have few normal parous samples, so we supplemented this research with mouse datasets, which contain mammary cells from various developmental stages. This research identified two novel normal breast cell populations that may be the origin of the basal-like and HER2-overexpressing subtypes, respectively. A stem cell-like population, SC, that expresses gestation-specific genes has similar gene expression patterns to basal-like BrCs. A novel luminal progenitor cell population and HER2-overexpressing BrCs are marked by S100A7, S100A8, and S100A9 expression. We bolstered our findings by examining SC gene expression in TN BrC scRNAseq datasets and S100A7-A9 gene expression in BrC cell lines. We discovered that several potential cancer stem cell populations highly express most of the SC genes in TN BrCs and confirmed S100A8 and A9 overexpression in a HER2-overexpressing BrC cell line. In summary, normal SC and the novel luminal progenitor cell population likely give rise to basal-like and HER2-overexpressing BrCs, respectively. Characterizing these normal cell populations may facilitate a better understanding of specific BrCs subtypes.
Relationship Between Sexual Behaviors with Non-committed Relationship Partners and COVID-19 Restrictions and Notification Rates: Results from a Longitudinal Study of Gay and Bisexual Men in Australia
Authors: Storer Daniel , Prestage Garrett , McManus Hamish , Maher Lisa , Bavinton Benjamin R. , Ellard Jeanne , Jin Fengyi , Philpot Steven , Holt Martin , Saxton Peter , Haire Bridget , Murphy Dean , Hammoud Mohamed A. 
Published: May 2022

Abstract
Introduction
COVID-19 related lockdowns have impacted the sexual activity of gay and bisexual men (GBM). We investigated trends in sexual behaviors and the COVID-19 context in which they occurred (COVID-notification rates and jurisdictional restrictions) to understand changes in the duration and severity of periods of lockdown on the sexual behavior of Australian GBM.

Methods
In an online, prospective observational study of 831 GBM from May 2020 to May 2021, we investigated associations between changes in sexual behavior among Australian GBM, lockdowns, and COVID-19 notification rates through weekly surveys from May 2020 to May 2021.

Results
The mean age was 45.71 years (SD: 13.93). Most identified as gay (89.0%) and 10.2% were living with HIV. There was an overall increase in the mean weekly number of non-committed relationship partners (0.53–0.90, p < 0.001). The state of Victoria experienced a significant extended COVID-19 outbreak, accompanied by severe lockdown restrictions. In response, Victorian men’s partner numbers shifted three times, while elsewhere there was an overall gradually increasing trend.

Conclusions
Less severe outbreaks with shorter lockdown periods, involving fewer and geographically contained, COVID-19 notifications were accompanied by non-significant changes in sex with non-relationship partners than more severe outbreaks over extended periods and larger geographical areas.
Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke
Authors: Ye Baoye , Wei Dingqun , Pan Lin 
Published: May 2022

Abstract
Objective
The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive dysfunction after basal ganglia stroke, and factors affecting total MoCA score were examined.

Methods
Data were retrospectively analyzed for 30 patients with basal ganglia intracerebral hemorrhage or basal ganglia cerebral infarction, who were admitted to The Second Affiliated Hospital of Fujian Traditional Medical University (Fujian, China) from January 2017 to March 2020. Cognitive impairment was assessed using the MoCA, and potential correlations were explored between clinicodemographic characteristics (sex, age, stroke location and etiology) and MoCA dimensions or total MoCA score.

Results
Univariate linear regression showed that the total MoCA score was significantly associated with sex, age, executive function, naming, attention, abstract generalization ability, memory ability, and visuospatial orientation. However, multivariate linear regression identified only executive function, naming, attention, memory ability, and visuospatial orientation as significantly associated with the total MoCA score.

Conclusions
We showed that the MoCA test can be used for patients with basal ganglia stroke. The total MoCA score of basal ganglia stroke was significantly associated with impairments in executive function, naming, attention, memory ability, and visuospatial orientation.
Cytomegalovirus infection and rehospitalization rates after allogeneic hematopoietic stem cell and solid organ transplantation: a retrospective cohort study using German claims data
Authors: Teschner Daniel , Knop Jana , Piehl Christian , Junker Sophia , Witzke Oliver 
Published: May 2022

Abstract
Purpose
This study aimed to describe the cytomegalovirus (CMV) infection rate, rehospitalizations, and comorbidities following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and solid organ transplantation (SOT).

Methods
Patients who received allo-HSCT or SOT in 01/07/2015–30/06/2018 were identified using anonymized German claims data. The transplantation-related hospital admission date was defined as the index date, and patients were followed for up to 12 months (or death, first event relevant). The frequency of CMV infections (confirmed outpatient/inpatient diagnoses, ICD-10-GM codes: B25.-/B27.1) and the rate, number, and duration of all-cause rehospitalizations in the follow-up period were evaluated.

Results
A total of 226 allo-HSCT and 250 SOT patients were identified (mean age 52.8 years, 38.9% female). During the 12 months after transplantation, 29.2% of allo-HSCT patients and 16.8% of SOT patients received a CMV diagnosis. The majority of these diagnoses were given during the initial hospitalization or within the following 3 months. Across transplantation types, CMV patients had more hospital readmission days per patient-year (allo-HSCT 93.3 vs. 49.4, p = 0.001; SOT 42.0 vs. 20.7, p = 0.005), with a longer mean duration of readmissions (allo-HSCT 22.4 vs. 15.4 days, p < 0.001; SOT 11.6 vs. 7.5 days, p = 0.003). Comorbidity burden in transplantation patients was substantial, with several diagnoses being significantly more common among patients with CMV vs. non-CMV. One-year mortality did not differ significantly between patients with/without CMV.

Conclusion
Burden of transplant recipients with CMV in terms of rehospitalizations and comorbidities is substantial, highlighting the need for improved CMV prevention and treatment.
The Association Between Mental Well-Being and School Attendance Among Palestinian Adolescent Refugees in UNRWA Schools
Authors: Nathani Komal , Lee Wei-Chen , Taha Shaden , Horino Masako , Seita Akihiro , Serag Hani 
Published: May 2022

AbstractAdolescent refugees experience psychosocial stressors, including traumatic events, poverty, and loss of home and family. Exposure to conflict affects mental well-being in Palestinian adolescent refugees. Adolescent girls are among those vulnerable to post-traumatic stress associated with living in conflict zones, We assessed the association between reported mental well-being and school attendance among Palestinian adolescent refugees in UNRWA schools in Occupied Palestinian Territories, Jordan, Lebanon, and Syria. We also examined differences based on gender and place of residence, Palestinian adolescent refugees with certain mental well-being concerns were more likely to miss more days of school. Generally, females reported higher rates of loneliness and worry, but males were more likely to miss school. Gender-based differences were highest in Lebanon and least in the West Bank, More school-based and community-based mental well-being interventions are needed. Female-tailored programs are needed, especially in Palestinian refugee camps in Lebanon.
A novel ensemble feature selection method for pixel-level segmentation of HER2 overexpression
Authors: Aguilera Ana , Pezoa Raquel , Rodríguez-Delherbe Andrea 
Published: May 2022

AbstractClassifying histopathology images on a pixel-level requires sets of features able to capture the complex characteristics of the images, like the irregular cell morphology and the color heterogeneity on the tissue aspect. In this context, feature selection becomes a crucial step in the classification process such that it reduces model complexity and computational costs, avoids overfitting, and thereby it improves the model performance. In this study, we propose a new ensemble feature selection method by combining a set of base selectors, classifiers, and rank aggregation methods, aiming to determine from any initial set of handcrafted features, a smaller set of relevant color and texture pixel-level features, subsequently used for segmenting HER2 overexpression on a pixel-level, in breast cancer tissue images. We have been able to significantly reduce the set of initial features, using the proposed ensemble feature selection method. The best results are obtained using $$\chi ^2$$

χ
2

, Random Forest, and Runoff as the based selector, classifier, and aggregation method, respectively. The classification performance of the best model trained on the selected features set results in 0.939 recall, 0.866 specificity, 0.903 accuracy, 0.875 precision, and 0.906 F1-score.
A Multiple and Multidimensional Linguistic Truth-Valued Reasoning Method and its Application in Multimedia Teaching Evaluation
Authors: Lu Yifan , Li Nan , Lin Hongmei , Zheng Hongliang , Li Xiaofeng , Zou Li 
Published: May 2022

AbstractWith the expansion of the epidemic, online multimedia teaching has become a common trend. The reasoning model of multimedia teaching evaluation is a useful tool to infer the result of teaching effects and predict the tendency. However, the ambiguity in the linguistic-valued evaluation leads to reasoning problems always in the context with uncertainty. To make the reasoning model better deal with multiple and multidimensional reasoning problems in uncertainty environment, while considering both positive evidence and negative evidence at the same time, this paper mainly focuses on a linguistic truth-valued intuitionistic fuzzy layered aggregation (LTV-IFLA) reasoning method. First, based on the layered linguistic truth-valued intuitionistic fuzzy lattice (LTV-IFL), we realize aggregating the linguistic truth-valued information through the layered average aggregation (LAA) operator presented by this paper. Furthermore, a layered weighted average aggregation (LWAA) operator is proposed to consider setting different weights to achieve personalization of the reasoning results. Finally, a multiple multidimensional reasoning model which simulates the reasoning of human language is presented to illustrate the method’s rationality and validity.
Determine both the conformation and orientation of a specific residue in α-synuclein(61–95) even in monolayer by 13C isotopic label and p-polarized multiple-angle incidence resolution spectrometry (pMAIRS)
Authors: Wang Chengshan , Zhou Yiqun , Ewuola Christopher , Akinleye Toyin , Hasegawa Takeshi , Leblanc Roger M. 
Published: May 2022

Abstract
Protein’s magic function stems from its structure and various analytical techniques have been developed for it. Among proteins, membrane proteins are encoded 20–30% of genomes, whereas cause challenges for many analytical techniques. For example, lots of membrane proteins cannot form single crystal structure required by X-ray crystallography. As for NMR, the measurements were hindered by the low tumbling rates of membrane (i.e., phospholipid bilayers) where membrane proteins exist. In addition, membrane proteins usually lay parallel to the surface of phospholipid bilayers or form transmembrane structure. No matter parallel or perpendicular to phospholipid bilayers surface, membrane proteins form monolayer structure which is also difficult for X-ray and NMR to provide high-resolution results. Because NMR and X-ray crystallography are the two major analytical techniques to address protein’s structure, membrane proteins only contribute 2.4% to the solved protein databank. Surface FT-IR techniques can evaluate the conformation and orientation of membrane proteins by amide I band. Specifically for α-helical peptides/proteins, the orientation of the axis is critical to decide whether proteins form transmembrane structure. Notice that the traditional FT-IR can only provide “low-resolution” results. Here, 13C isotope was introduced into the nonamyloid component (NAC), which spans residues 61–95 of α-synuclein (α-syn). Then, p-polarized multiple-angle incidence resolution spectrometry (pMAIRS) was used to determine the orientation of a specific residue of α-helical NAC in monolayer. In general, pMAIRS is a novel technique to work complementary with X-ray and NMR to address membrane peptides/proteins structure with high resolution even in monolayer.

Graphical abstract
Neurovascular Compression in the Anterior Visual Pathway: A Case Series
Authors: Gelkopf Maxwell J. , Jabehdar Maralani Pejman , da Costa Leodante , Birt Catherine , Sundaram Arun N. E. 
Published: May 2022

ABSTRACT:A retrospective review of 29 patients with neurovascular compression syndrome (NVCS) involving the anterior visual pathway was conducted. Various patterns of NVCS and visual defects were identified, most commonly involving the optic nerve and internal carotid artery. Most patients were stable, except one with progressive visual field defects. Although mostly asymptomatic, NVCS can rarely cause compressive optic neuropathy. NVCS should be kept in the differential diagnosis of normal tension glaucoma, especially with progressive visual loss despite treatment. Patients with progressive visual loss may require decompression surgery. Non-contrast computed tomography scan may miss NVCS, and magnetic resonance imaging is diagnostic.
Conceptual Framework for Understanding Incident Management Systems During Public Health Emergencies
Authors: Clark-Ginsberg Aaron , Fisher Holly , Awan Jalal , Rico Adriana , Thomas Tracy , Rose Dale , Vagi Sara , Jenkins Leecresia , Nelson Christopher 
Published: May 2022

Abstract

Objective:
Effective incident management is essential for coordinating efforts of multiple disciplines and stakeholders when responding to emergencies, including public health disasters such as the ongoing coronavirus disease 2019 (COVID-19) pandemic.

Methods:
Existing research frameworks tend to focus on formal structures and doctrine (eg, ICS-NIMS); however, organizational processes that underlie incident management have not been systematically assessed and synthesized into a coherent conceptual framework.

Results:
The lack of a framework has hindered the development of measures of performance that could be used to further develop the evidence base and facilitate process improvement. To address this gap, we present a conceptual framework of incident management drawn from expert feedback and a review of literature on incident management and related fields. The framework features 23 measurement constructs grouped into 5 domains: (1) situational awareness and information sharing, (2) incident action and implementation planning, (3) resource management and mobilization, (4) coordination and collaboration, and (5) feedback and continuous quality improvement.

Conclusions:
As such, the article provides a first step toward the development of robust measures for assessing the performance and effectiveness of incident management systems.