bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution education in light of religious science teachers’ and scientists’ conceptions of evolution and religion
Authors: Stahi-Hitin Reut , Yarden Anat 
Published: June 2022

Abstract
Background
The presumed conflict between religion and evolution is considered one of the main causes of rejection of evolution worldwide. However, there is a unique group of religious people who accept, study, and teach evolution. The aim of this study was to gain a better understanding of these individuals’ conception of the relationship between evolution and religion, and the factors that influenced this conception. Religious biology teachers (n = 10) and scientists (n = 10) were surveyed and interviewed about their conception of evolution and religion and the factors that influenced it.

Results
The study population demonstrated that reconciling science and religion was possible for them. The interpretation of the bible as moral guidance, and not as a science book, was found to be a main idea in the participants’ conception. Most participants said that their conception of evolution was influenced by their parents’ and teachers’ approach to science. Participants who had rejected evolution in the past emphasized that exposure to scientific knowledge alone was not enough to counter this rejection, whereas exposure to the possible compatibility between religion and evolution promoted their acceptance.

Conclusions
These findings suggest the importance of exposing teachers to different approaches to the relationship between evolution and religion. Implementation of the study conclusions in professional development programs may help teachers promote religiously affiliated students’ better learning of evolution and a meaningful learning of science in general.
ACO:lossless quality score compression based on adaptive coding order
Authors: Niu Yi , Ma Mingming , Li Fu , Liu Xianming , Shi Guangming 
Published: June 2022

Abstract
Background
With the rapid development of high-throughput sequencing technology, the cost of whole genome sequencing drops rapidly, which leads to an exponential growth of genome data. How to efficiently compress the DNA data generated by large-scale genome projects has become an important factor restricting the further development of the DNA sequencing industry. Although the compression of DNA bases has achieved significant improvement in recent years, the compression of quality score is still challenging.

Results
In this paper, by reinvestigating the inherent correlations between the quality score and the sequencing process, we propose a novel lossless quality score compressor based on adaptive coding order (ACO). The main objective of ACO is to traverse the quality score adaptively in the most correlative trajectory according to the sequencing process. By cooperating with the adaptive arithmetic coding and an improved in-context strategy, ACO achieves the state-of-the-art quality score compression performances with moderate complexity for the next-generation sequencing (NGS) data.

Conclusions
The competence enables ACO to serve as a candidate tool for quality score compression, ACO has been employed by AVS(Audio Video coding Standard Workgroup of China) and is freely available at https://github.com/Yoniming/ACO.
Transient J wave-like ST-segment elevation in intracerebral hemorrhage: a case report
Authors: Du Xing , Zhang Yongjun 
Published: June 2022

Abstract
Background
Certain cerebrovascular events can induce electrocardiography (ECG) abnormalities and cardiac dysfunction. The most frequent patterns reported are nonspecific ST-T change, inverted or broad T wave, prolongation of QT interval as well as ST-segment depression or elevation. Here we present a case of intracerebral hemorrhage (ICH) with transient J wave-like ST-segment elevation accompanied by myocardial lesion.

Case presentation
A 58-year-old woman was admitted to our hospital and diagnosed with right basal ganglia region cerebral hemorrhage. The ECG recorded on the second hospital day showed transient J wave-like ST-segment elevation accompanied by increased myocardial troponin I and myocardial enzyme.

Conclusions
The J wave-like ST-segment elevation may be not a specific ECG signs for primary ischemic heart diseases as it also could be found in ICH patients. We believe that the follow-up ECGs can be used in conjunction with repeated myocardial enzyme analysis and echocardiography to differentiate ICH-ralated J wave-like ST-segment elevation from acute myocardial infarction (AMI), thus avoiding unnecessary cardiac catheterization.
Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection
Authors: Fuchino Takafumi , Wada Yasuhiro , Kodama Masaaki , Mukaisho Ken-ichi , Mizukami Kazuhiro , Okimoto Tadayoshi , Kushima Ryoji , Murakami Kazunari 
Published: June 2022

Abstract
Background
Pancreatic acinar cell metaplasia (PACM) has been rarely reported in the gastric mucosa. In the present study, we aimed to elucidate the clinical and pathological characteristics of PACM associated with Helicobacter pylori (H. pylori).

Method
5930 patients who underwent five- or two-point gastric biopsy according to the updated Sydney system (USS) by upper gastrointestinal endoscopy were enrolled. The patients were categorized into current H. pylori infection (CHI), post-H. pylori eradication (PHE), and non-H. pylori infection (NHI) groups according to the H. pylori infection status, and the frequency and location of PACM were compared. Additionally, a case–control study was performed to compare the USS scores between patients with CHI and PACM and those with CHI but not PACM.

Result
The frequencies of PACM were 0.49% (10/2039), 0.75% (25/3332), and 0% (0/559) in the CHI, PHE, and NHI groups, respectively. PACM was found in the greater curvature of the antrum in 33 of the 35 patients with PACM. Among the patients with CHI, the inflammation scores in the greater curvature of the antrum and the greater curvature of the corpus were lower in patients with PACM than in those without PACM.

Conclusion
Although rarely reported in the gastric mucosa, PACM was closely related to H. pylori infection, especially in the antrum, and was associated with relatively mild inflammation.
Physical activity measured by accelerometry in paediatric and young adult patients with inflammatory bowel disease
Authors: Lund Ken , Larsen Michael Due , Knudsen Torben , Kjeldsen Jens , Nielsen Rasmus Gaardskær , Brage Søren , Nørgård Bente Mertz 
Published: June 2022

Abstract
Objectives
Physical activity in paediatric and young adult patients suffering from inflammatory bowel disease (IBD) may play an important role in the overall health status. However, physical activity in these patients has not been reported using objective methods. We aimed to describe accelerometry-measured physical activity levels in paediatric and young adult IBD patients with either ulcerative colitis (UC) or Crohn’s disease (CD).

Methods
We recruited Danish patients with IBD aged 10–20 years in clinical remission and with a faecal calprotectin below 200 µg/mg. Physical activity was assessed using tri-axial wrist accelerometry over seven days and quantified using the activity-related acceleration derived as the conventional Euclidian Norm Minus One (ENMO) metric expressed in milli-gravity units (mg). Time spent in Moderate-to-Vigorous Physical Activity (MVPA) was classified as ENMO > 210 mg in 5 s epoch resolution (unbouted).

Results
We included 61 patients with a median age of 17 years [Inter Quartile Range, IQR 14–19]. The total volume of activity expressed as average acceleration (ENMO) per day was 31.5 mg (95% CI 29.1–33.9). Time spent in unbouted MVPA was 32 min per day (95% CI 26–37). There was no significant difference in activity volume between patients with UC to patients with CD, the adjusted linear regression coefficient was − 1.7 mg (95% CI –6.2–2.7). Activity volume was higher for males (36.2 mg, 95% CI 31.9–40.5) than for females (27.8 mg, 95% CI 25.6–30.0), and younger patients were more active than older patients; Activity volume in 10–13 year olds was 37.2 mg (95% CI 28.6–45.7), whereas it was 28.5 mg (95% CI 25.2–31.7) for those aged 18–20 years.

Conclusions
We collected tri-axial accelerometry in young patients with IBD in clinical remission, and described their level of physical activity by the conventional ENMO measure. We found no statistically significant difference in patients with UC compared to patients with CD. The volume of physical activity was higher in males compared to females, and inversely associated with age.
Association of body mass index and waist circumference with type 2 diabetes mellitus in older adults: a cross-sectional study
Authors: Bai Kaizhi , Chen Xuejiao , Song Rui , Shi Wenlong , Shi Songhe 
Published: June 2022

Abstract
Background
The prevalence of obesity and diabetes is rising. The aim of this study was to determine the association of body mass index (BMI) and waist circumference (WC) with type 2 diabetes mellitus (T2DM) in the elderly and to compare the discriminatory abilities of BMI, WC and other anthropometric indicators, including waist-to-height ratio (WHtR), body adiposity estimator (BAE) and body roundness index (BRI) for T2DM.

Methods
This cross-sectional study included 69,388 subjects aged ≥ 60 years living in Xinzheng, Henan Province, from January to December 2020. The data came from the residents’ electronic health records of the Xinzheng Hospital Information System. Logistic regression was used to examine the relationships. Fully adjusted models adjusted for age, sex, place of residence, alcohol consumption, smoking, physical exercise, SBP and RHR. The area under the receiver operating characteristic curve (AUC) was used to compare the discriminatory ability of different anthropometric indicators for T2DM under the influence of potential risk factors.

Results
After adjusting for multiple covariates, compared with the first BMI quintile, the odds ratios (ORs) and 95% confidence intervals (CIs) from the second to fifth quintile for T2DM were 1.416 (1.335–1.502), 1.664 (1.570–1.764), 1.879 (1.774–1.990) and 2.156 (2.037–2.283), respectively. Compared with the first WC quintile, the ORs and 95% CIs from the second to fifth quintiles for T2DM were 1.322 (1.244–1.404), 1.549 (1.459–1.643), 1.705 (1.609–1.807) and 2.169 (2.048–2.297), respectively. Among men, compared with other anthropometric indicators (BMI, WHtR, BAE and BRI), WC showed the highest AUC (AUC: 0.629; 95% CI: 0.622–0.636). Among women, the AUCs of BMI (AUC: 0.600; 95% CI: 0.594–0.606), WC (AUC: 0.600; 95% CI: 0.593–0.606) and BAE (AUC: 0.600; 95% CI: 0.594–0.607) were similar, and the AUCs of BMI, WC and BAE were higher than WHtR, BRI.

Conclusions
All anthropometric indicators were positively associated with T2DM. In men, WC with the strongest positive association with T2DM was the best predictor of T2DM. In women, BMI was most strongly associated with T2DM, and the predictive powers of BMI, WC and BAE were similar. After adjusting the potential confounding factors including age, sex, place of residence, alcohol consumption, smoking, physical exercise, SBP and RHR, the effect of these factors was eliminated, the findings were independent of the covariates considered.
Factors influencing the stages of frailty among Korean older adults focusing on objective and subjective social isolation
Authors: Han Song Yi , Jang Hye Young , Ko Young 
Published: June 2022

Abstract
Background
Although many studies have investigated the factors influencing frailty, few studies have confirmed the influence of social factors on the stages of frailty. This study was conducted to identify factors influencing the stages of frailty in Korean older adults, focusing on objective and subjective social isolation.

Methods
This study analyzed the data of 10,041 older adults from the 2017 National Survey of Older Koreans. Two multiple logistic regression analyses were performed to identify the factors influencing the frailty stages. Frailty was calculated using the FRAIL scale with the five domains: fatigue, resistance, ambulation, illness, and loss of weight.

Results
Among Korean older adults, 51.5% were in the robust stage, 42.5% in the pre-frail stage and 6.0% in the frail stage. As a multiple logistic regression analysis, participants with an intimate relationship (Odds ratio (OR) 0.93, 95% Confidential interval (CI) = 0.91–0.95) or objective social non-isolated participants were more likely to be in the robust group than the pre-frail group. Objective social-isolated participants were more likely to belong to the frail group than the pre-frail group: isolation from family member only (OR 1.57, 95% CI = 1.04–2.39), isolation from non-family member only (OR 1.75, 95% CI = 1.39–2.19), and isolation from both family and non-family member (OR 2.56, 95% CI = 1.67–3.92).

Conclusions
This cross-sectional study showed that social isolation was associated with the stage of frailty. Therefore, researchers need to consider issues of social isolation of older adults in the development of frailty prevention and management intervention.
Predicting the onset of freezing of gait in Parkinson’s disease
Authors: Wang Fengting , Pan Yixin , Zhang Miao , Hu Kejia 
Published: June 2022

AbstractBackgroundFreezing of gait is a debilitating symptom of Parkinson’s disease associated with high risks of falls and poor quality of life. While productive therapy for FoG is still underway, early prediction of FoG could help high-risk PD patients to take preventive measures. In this study, we predicted the onset of FoG inde novoPD patients using a battery of risk factors from patients enrolled in PPMI cohort.MethodsBaseline characteristics were compared between subjects who developed FoG (68 patients, 37.2%, pre-FoG group) during the five-year follow up and subjects who did not (115 patients, 62.8%, non-FoG group). A multivariate logistic regression model was built based on backward stepwise selection of factors that were associated with FoG onset in the univariate analysis. ROC curves were used to assess sensitivity and specificity of the predictive model.ResultsAt baseline, age, PIGD score, cognitive functions, autonomic functions, sleep behavior, fatigue and striatal DAT uptake were significantly different in the pre-FoG group relative to the non-FoG group. However, there was no difference in genetic characteristics between the two patient sets. Univariate analysis showed several motor and non-motor factors that correlated with FoG, including PIGD score, MDS-UPDRS part II score, SDMT score, HVLT Immediate/Total Recall, MOCA, Epworth Sleepiness Scale, fatigue, SCOPA-AUT gastrointestinal score, SCOPA-AUT urinary score and CSF biomarker Abeta42. Multivariate logistic analysis stressed that high PIGD score, fatigue, worse SDMT performance and low levels of Abeta42were independent risk factors for FoG onset in PD patients.ConclusionsCombining motor and non-motor features including PIGD score, poor cognitive functions and CSF Abeta can identify PD patients with high risk of FoG onset.
Inactivated COVID-19 vaccine induced acute stroke-like focal neurologic symptoms: a case series
Authors: Roongpiboonsopit Duangnapa , Nithisathienchai Chichaya , Akarathanawat Wasan , Lertutsahakul Krittanon , Tantivattana Jarturon , Viswanathan Anand , Suwanwela Nijasri Charnnarong 
Published: June 2022

AbstractBackgroundA subgroup of individuals experienced stroke-like symptoms after receiving an inactivated COVID-19 vaccine. We present clinical characteristics, neuroimaging, and outcome of these patients.MethodsMedical personals who had neurological symptoms after receiving inactivated COVID-19 vaccine were enrolled. Clinical, laboratory investigation and neuroimaging were collected. Subjects were prospectively followed-up on clinical and neuroimaging to detect brain parenchymal or cerebrovascular abnormality.ResultsNineteen out of 385 subjects (4.9%) developed neurological symptoms after vaccination. There was a female predominance (89.5%) with mean age of 34 ± 7.5 years. Majority of patients (52.6%) had symptoms within 60 min after vaccination. The most common neurological symptoms were numbness (94.7%) followed by headache (52.6%) and weakness (47.4%). The most common neurological signs were sensory deficit (79%) followed by motor weakness (52.6%) and tongue deviation (26.3%). Recurrent headache was observed in most patients (89.5%) during followed up. Serial brain imaging was done in all patients with median follow-up interval of 18 days. There was no evidence of acute brain infarction in any of the patients, 84.2% had no vascular abnormality, 15.8% had transient focal narrowing of cerebral vessels. Outcome was favorable, modified ranking scale 0–1 for all patients at 4 weeks after vaccination.ConclusionsTransient focal neurological symptoms and deficits can be found after COVID-19 vaccination. However, benefit to stop COVID-19 pandemic by vaccination is outweighed by these seemingly reversible side effects. The pathophysiology underlined these phenomena should be further investigated.
Cesarean section in Uruguay from 2008 to 2018: country analysis based on the Robson classification. An observational study
Authors: Colomar Mercedes , Colistro Valentina , Sosa Claudio , de Francisco Luis Andres , Betrán Ana Pilar , Serruya Suzanne , De Mucio Bremen 
Published: June 2022

Abstract
Background
The use of caesarean section has steadily increased, with Latin America being the region with the highest rates. Multiple factors account for that increase and the Robson classification is appropriate to compare determinants at the clinical level for caesarean section rates over time. The purpose of this study is to describe the evolution of caesarean section rates by Robson groups in Uruguay from 2008 to 2018 using a country level database.

Methods
We included the records of all women giving birth in Uruguay (pregnancies ≥22 weeks and weights ≥500 g) with valid data in the mode of childbirth recorded in the Perinatal Information System database between 2008 and 2018. Caesarean section rates were calculated by Robson groups for each of the years included, disaggregated by care sector (public/private) and by geographical area (Capital City/Non-Capital), with time trends and their significance analyzed using linear regression models.

Results
Of the total 485,263 births included in this research, the overall caesarean section rate was 43,1%. In 2018, among the groups at lower risk of caesarean section (1 to 4), the highest rates were seen in women in group 2B (98,8%), followed by those in group 4B (97,9%). A significant increase in the number of caesarean sections was seen in groups 2B (97,9 to 98,8%), 3 (8,36 to 11,1%) and 4 (A (22,7 to 26,9%) and B (95,4 to 97,9%) Significant growth was also observed in groups 5 (74,3 to 78,1%), 8 (90,6 to 95,5%), and 10 (39,1 to 46,7%). The private sector had higher rates of caesarean section for all groups throughout the period, except for women in group 9. The private sector in Montevideo presented the highest rates in the groups with the lowest risk of caesarean section (1, 2A, 3 and 4A), followed by the private sector outside of the capital.

Conclusion
Uruguay is no exception to the increasing caesarean section trend, even in groups of women who have lower risk of requiring caesarean section. The implementation of interventions aimed at reducing caesarean section in the groups with lower obstetric risk in Uruguay is warranted.
Closed isolated anterolateral calcaneal dislocation: a case report
Authors: Vosoughi Amir Reza , Akbarzadeh Armin , Zakaee Alireza 
Published: June 2022

Abstract
Background
Complete isolated calcaneal dislocation, defined as dislocation of talocalcaneal and calcaneocuboid joints with intact talonavicular joint without significant fracture, is an exceedingly rare injury.

Case presentation
A 49-year-old man, after a motor vehicle collision, presented with a closed isolated anterolateral dislocation of the calcaneus associated with fracture of the sustentaculum tali, cuboid, lateral process of the talus, and avulsion fracture of superior peroneal retinaculum. Urgent successful closed reduction was immediately performed in the emergency room under sedation. Two days later, through sinus tarsi approach extended proximally to posterior of the lateral malleolus and distally to the calcaneocuboid joint, peroneal tendons were reduced in the retromalleolar groove and avulsion fracture of the superior peroneal retinaculum was reduced and fixed by a suture anchor. A chondral lesion (6 × 8 mm) was seen in the posterior facet of the calcaneus for that chondroplasty and microfracture were performed. Also, small bony fragments from the cuboid were excised. The reduced calcaneocuboid joint was fixed by two Kirschner wires. In the second stage, 10 days later, through medial approach to the talocalcaneal joint, multiple free bony fragments were excised. Then sustentaculum tali was reduced and fixed using a lag screw. Postoperatively, a non-weight bearing short leg cast was applied for six weeks. The patient had permission to start partial weight bearing 6 weeks after removal of K-wires. Finally, at the 10th postoperative week, he had full weight-bearing without any aid instrument. He was able to return to his regular activities about 6 months after the injury. At 34 months, the American Orthopaedic Foot and Ankle Society ankle-hindfoot scale was 92 from 100. The foot function index percentile was 7% and the visual analogue score for pain was 1.9. The last radiographs revealed normal configuration of talocalcaneal, calcaneocuboid, and talonavicular joints with a little joint space narrowing in posterior part of the subtalar joint.

Conclusion
Patients with isolated anterolateral calcaneal dislocations, even with multiple associated fractures, can have acceptable outcomes, if it is urgently diagnosed and properly managed.
Ultrasound-guided needle release of A1 pulley combined with corticosteroid injection is more effective than ultrasound-guided needle release alone in the treatment of trigger finger
Authors: Wu Yan-Yan , Chen Kai , He Fan-Ding , Quan Jie-Rong , Guo Xuan-Yan 
Published: June 2022

Abstract
Background
The purpose of the present study was to evaluate the clinical effectiveness of ultrasonography-guided needle release of A1 pulley combined with corticosteroid injection by comparing it with ultrasound-guided needle release of the A1 pulley alone.

Methods
A total of 49 patients (55 fingers, thumb) with trigger fingers were included in this retrospective study. Twenty-seven fingers were treated with ultrasound-guided needle release of the A1 pulley alone (monotherapy group), and 28 fingers were treated with needle release of the A1 pulley combined with corticosteroid injection (combination group). Visual analog scale (VAS), Froimson scale, postoperative recurrence rate, and thickness of A1 pulley at baseline, Week-2, Week-12, and Month-6 were recorded.

Results
Higher clinical cure rates were observed in the combination group at Week-2 after treatment among patients with the Froimson scale Grade III and IV (p < 0.05). Among Froimson scale Grade IV patients, the combination group had a significantly thinner thickness of A1 pulley and better articular pain relief at Week-2 (all p < 0.05). No significant differences were found in the clinical cure rate, the thickness of the A1 pulley, articular pain relief, and recurrence rate between the two groups at Week-12 and Month-6 (all p > 0.05).

Conclusions
Ultrasonography-guided needle release of A1 pulley plus corticosteroid injection was superior to ultrasonography-guided A1 pulley needle release alone during early-stage treatment of severe patients with trigger fingers. Moreover, ultrasonography-guided A1 pulley needle release combined with corticosteroid injection narrows the thickness of the A1 pulley. It is necessary to carry out preoperative evaluation and individualized treatment for patients of various severities.