bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass transfer in AGB binaries - uncovering a new evolution channel by 3D radiation-hydrodynamic simulations
Authors: Chen Zhuo , Ivanova Natalia , Carroll-Nellenback Jonathan 
Published: November 2022

AbstractThe origin of chemically peculiar stars and nonzero eccentricity in evolved close binaries have been long-standing problems in binary stellar evolution. Answers to these questions may trace back to an intense mass transfer during the asymptotic-giant-branch (AGB) binary phase. We use AstroBEAR to solve the 3D radiation hydrodynamic equations and calculate the mass transfer rate in AGB binaries that undergo the wind-Roche-lobe overflow or Bondi-Hoyle-Lyttleton (BHL) accretion. One of the goals of this work is to illustrate the transition from the wind- Roche-lobe overflow to BHL accretion. Both circumbinary disks and spiral structure outflows can appear in the simulations. As a result of enhanced mass transfer and angular momentum transfer, some AGB binaries may undergo orbit shrinkage, and some will expand. The high mass transfer efficiency is closely related to the presence of the circumbinary disks.
Gender, intimate partner homicide, and rurality in early-twentieth-century New South Wales
Authors: Strange Carolyn , Payne Collin , Fraser Fiona 
Published: November 2022

AbstractRural criminological literature on lethal domestic violence and feminist historical research on the patriarchal judgment of women accused of killing male intimate partners (IPs) have developed a dystopic image of the past for nonurban women. This paper questions that impression by asking whether women were more likely than men to be convicted of IP murder, and whether rural women were treated more harshly than urban women. Through quantitative analysis of 221 IP murder trials in New South Wales, 1901–1955, plus four representative case studies, it reveals that women tried for IP murders in rural areas were treated more leniently than their urban counterparts and significantly less harshly than male perpetrators of IP homicide. This paper demonstrates how historical criminological analysis of illustrative qualitative evidence, grounded in quantitative data on locational distinctions, can expose significant variations over time and place in the fate of abused women prosecuted for IP homicide.
Lithospheric and Slab Configurations From Receiver Function Imaging in Northwestern South America, Colombia
Authors: Mojica Boada Manuel Jose , Poveda Esteban , Tary Jean Baptiste 
Published: November 2022

AbstractThe northwestern corner of South America presents a highly complex geodynamical setting including the convergence between South America, Nazca, and Caribbean plates; which also entails heterogeneity and complexity in the lithospheric structure. Here, we present depth‐migrated common‐conversion point (CCP) teleseismic receiver function profiles carried out using seismological data between 2011 and 2020 from the Colombian Geological Service, combined with some stations of observatories and international networks. These profiles provide better constraints on the lateral interpretation of the main lithospheric discontinuities in this region. We provide an updated crustal thickness map displaying some differences from previous studies, especially in the northernmost part of the cordilleran system. Our results also show some intracrustal features such as the regional detachment surface beneath the Eastern Cordillera and the presence of deep melt reservoirs under the Central Cordillera and the Paipa‐Iza complex in the Eastern Cordillera. We also discuss the lithospheric thickness and the potential existence of a highly hydrated and serpentinized mantle wedge under the forearc over the slab segment south of the Caldas tear. Furthermore, the CCP profiles further support the subduction system segmentation under northwestern South America, with at least five slab segments, two of them overlapping between ∼5.5 and ∼8°N, three belonging to the Nazca plate, and two having a Caribbean origin. The Bucaramanga nest appears to be linked to the interaction between the two northmost slab segments, while the Cauca cluster might be related to a slab dehydration process of a highly fractured zone.
Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation
Authors: Li Gaifen , Liu Jia , Guo Mengyuan , Gu Yakun , Guan Yuying , Shao Qianqian , Ma Wei , Ji Xunming 
Published: November 2022

AbstractChronic hypoxia leads to irreversible cognitive impairment, primarily due to hippocampal neurodegeneration, for which the underlying mechanism remains poorly understood. We administered hypoxia (13%) to C57BL mice for 1–14 days in this study. Chronic hypoxia for 7 or 14 d, but not 1 or 3 d, resulted in alpha-synuclein hyperphosphorylation at serine129 (α-Syn p-S129) and protein aggregation, hippocampal neurodegeneration, and cognitive deficits, whereas the latter could be prevented by alpha-synuclein knockdown or an administered short peptide competing at α-Syn S129. These results suggest that α-Syn p-S129 mediates hippocampal degeneration and cognitive impairment following chronic hypoxia. Furthermore, we found that chronic hypoxia enhanced ceramide catabolism by inducing hypoxia-inducible factor (HIF)-2α and HIF-2α-dependent transcriptional activation of alkaline ceramidase 2 (Acer2). Thus, the enzymatic activity of protein phosphatase 2A (PP2A), a specific phosphatase for α-syn, is inhibited, leading to the sustained induction of α-Syn p-S129. Finally, we found that intermittent hypoxic preconditioning protected against subsequent chronic hypoxia-induced hippocampal neurodegeneration and cognitive impairment by preventing α-Syn p-S129. These results proved the critical role of α-syn pathology in chronic hypoxia-afforded cognitive impairment and revealed a novel mechanism underlying α-syn hyperphosphorylation during chronic hypoxia. The findings bear implications in developing novel therapeutic interventions for chronic hypoxia-related brain disorders.
Real-time chirality transfer monitoring from statistically random to discrete homochiral nanotubes
Authors: Fa Shixin , Shi Tan-hao , Akama Suzu , Adachi Keisuke , Wada Keisuke , Tanaka Seigo , Oyama Naoki , Kato Kenichi , Ohtani Shunsuke , Nagata Yuuya , Akine Shigehisa , Ogoshi Tomoki 
Published: November 2022

AbstractReal time monitoring of chirality transfer processes is necessary to better understand their kinetic properties. Herein, we monitor an ideal chirality transfer process from a statistically random distribution to a diastereomerically pure assembly in real time. The chirality transfer is based on discrete trimeric tubular assemblies of planar chiral pillar[5]arenes, achieving the construction of diastereomerically pure trimers of pillar[5]arenes through synergistic effect of ion pairing between a racemic rim-differentiated pillar[5]arene pentaacid bearing five benzoic acids on one rim and five alkyl chains on the other, and an optically resolved pillar[5]arene decaamine bearing ten amines. When the decaamine is mixed with the pentaacid, the decaamine is sandwiched by two pentaacids through ten ion pairs, initially producing a statistically random mixture of a homochiral trimer and two heterochiral trimers. The heterochiral trimers gradually dissociate and reassemble into the homochiral trimers after unit flipping of the pentaacid, leading to chirality transfer from the decaamine and producing diastereomerically pure trimers.
Constraints on exotic spin-velocity-dependent interactions
Authors: Wei Kai , Ji Wei , Fu Changbo , Wickenbrock Arne , Flambaum Victor V. , Fang Jiancheng , Budker Dmitry 
Published: November 2022

AbstractExperimental searches for exotic spin-dependent forces are attracting a lot of attention because they allow to test theoretical extensions to the standard model. Here, we report an experimental search for possible exotic spin-dependent force, specifically spin-and-velocity-dependent forces, by using a K-Rb-21Ne co-magnetometer and a tungsten ring featuring a high nucleon density. Taking advantage of the high sensitivity of the co-magnetometer, the pseudomagnetic field from this exotic force is measured to be ≤7 aT. This sets limits on coupling constants for the neutron-nucleon and proton-nucleon interactions in the range of ≥0.1 m (mediator boson mass ≤2 μeV). The coupling constant limits are established to be $$|{g}_{V}^{n}|\,\le \,8.2\times 1{0}^{-11}$$
∣

g

V

n

∣

≤

8.2
×
1

0

−
11

and $$|{g}_{V}^{p}|\,\le \,3.7\times 1{0}^{-10}$$
∣

g

V

p

∣

≤

3.7
×
1

0

−
10

, which are more than one order of magnitude tighter than astronomical and cosmological limits on the coupling between the new gauge boson such as Z’ and standard model particles.
Inner southern magnetosphere observation of Mercury via SERENA ion sensors in BepiColombo mission
Authors: Orsini S. , Milillo A. , Lichtenegger H. , Varsani A. , Barabash S. , Livi S. , De Angelis E. , Alberti T. , Laky G. , Nilsson H. , Phillips M. , Aronica A. , Kallio E. , Wurz P. , Olivieri A. , Plainaki C. , Slavin J. A. , Dandouras I. , Raines J. M. , Benkhoff J. , Zender J. , Berthelier J.-J. , Dosa M. , Ho G. C. , Killen R. M. , McKenna-Lawlor S. , Torkar K. , Vaisberg O. , Allegrini F. , Daglis I. A. , Dong C. , Escoubet C. P. , Fatemi S. , Fränz M. , Ivanovski S. , Krupp N. , Lammer H. , Leblanc François , Mangano V. , Mura A. , Rispoli R. , Sarantos M. , Smith H. T. , Wieser M. , Camozzi F. , Di Lellis A. M. , Fremuth G. , Giner F. , Gurnee R. , Hayes J. , Jeszenszky H. , Trantham B. , Balaz J. , Baumjohann W. , Cantatore M. , Delcourt D. , Delva M. , Desai M. , Fischer H. , Galli A. , Grande M. , Holmström M. , Horvath I. , Hsieh K. C. , Jarvinen R. , Johnson R. E. , Kazakov A. , Kecskemety K. , Krüger H. , Kürbisch C. , Leblanc Frederic , Leichtfried M. , Mangraviti E. , Massetti S. , Moissenko D. , Moroni M. , Noschese R. , Nuccilli F. , Paschalidis N. , Ryno J. , Seki K. , Shestakov A. , Shuvalov S. , Sordini R. , Stenbeck F. , Svensson J. , Szalai S. , Szego K. , Toublanc D. , Vertolli N. , Wallner R. , Vorburger A. 
Published: November 2022

AbstractMercury’s southern inner magnetosphere is an unexplored region as it was not observed by earlier space missions. In October 2021, BepiColombo mission has passed through this region during its first Mercury flyby. Here, we describe the observations of SERENA ion sensors nearby and inside Mercury’s magnetosphere. An intermittent high-energy signal, possibly due to an interplanetary magnetic flux rope, has been observed downstream Mercury, together with low energy solar wind. Low energy ions, possibly due to satellite outgassing, were detected outside the magnetosphere. The dayside magnetopause and bow-shock crossing were much closer to the planet than expected, signature of a highly eroded magnetosphere. Different ion populations have been observed inside the magnetosphere, like low latitude boundary layer at magnetopause inbound and partial ring current at dawn close to the planet. These observations are important for understanding the weak magnetosphere behavior so close to the Sun, revealing details never reached before.
Analysis of the first genetic engineering attribution challenge
Authors: Crook Oliver M. , Warmbrod Kelsey Lane , Lipstein Greg , Chung Christine , Bakerlee Christopher W. , McKelvey T. Greg , Holland Shelly R. , Swett Jacob L. , Esvelt Kevin M. , Alley Ethan C. , Bradshaw William J. 
Published: November 2022

AbstractThe ability to identify the designer of engineered biological sequences—termed genetic engineering attribution (GEA)—would help ensure due credit for biotechnological innovation, while holding designers accountable to the communities they affect. Here, we present the results of the first Genetic Engineering Attribution Challenge, a public data-science competition to advance GEA techniques. Top-scoring teams dramatically outperformed previous models at identifying the true lab-of-origin of engineered plasmid sequences, including an increase in top-1 and top-10 accuracy of 10 percentage points. A simple ensemble of prizewinning models further increased performance. New metrics, designed to assess a model’s ability to confidently exclude candidate labs, also showed major improvements, especially for the ensemble. Most winning teams adopted CNN-based machine-learning approaches; however, one team achieved very high accuracy with an extremely fast neural-network-free approach. Future work, including future competitions, should further explore a wide diversity of approaches for bringing GEA technology into practical use.
Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo
Authors: Tiyaboonchai Amita , Vonada Anne , Posey Jeffrey , Pelz Carl , Wakefield Leslie , Grompe Markus 
Published: November 2022

AbstractExpression of guide RNAs in the CRISPR/Cas9 system typically requires the use of RNA polymerase III promoters, which are not cell-type specific. Flanking the gRNA with self-cleaving ribozyme motifs to create a self-cleaving gRNA overcomes this limitation. Here, we use self-cleaving gRNAs to create drug-selectable gene editing events in specific hepatocyte loci. A recombinant Adeno Associated Virus vector targeting the Albumin locus with a promoterless self-cleaving gRNA to create drug resistance is linked in cis with the therapeutic transgene. Gene expression of both are dependent on homologous recombination into the target locus. In vivo drug selection for the precisely edited hepatocytes allows >30-fold expansion of gene-edited cells and results in therapeutic levels of a human Factor 9 transgene. Importantly, self-cleaving gRNA expression is also achieved after targeting weak hepatocyte genes. We conclude that self-cleaving gRNAs are a powerful system to enable cell-type specific in vivo drug resistance for therapeutic gene editing applications.
South Asian black carbon is threatening the water sustainability of the Asian Water Tower
Authors: Yang Junhua , Kang Shichang , Chen Deliang , Zhao Lin , Ji Zhenming , Duan Keqin , Deng Haijun , Tripathee Lekhendra , Du Wentao , Rai Mukesh , Yan Fangping , Li Yuan , Gillies Robert R. 
Published: November 2022

AbstractLong-range transport of black carbon from South Asia to the Tibetan plateau and its deposition on glaciers directly enhances glacier melt. Here we find South Asian black carbon also has an indirect effect on the plateau’s glaciers shrinkage by acting to reduce the water supply over the southern Tibetan plateau. Black carbon enhances vertical convection and cloud condensation, which results in water vapor depletion over the Indian subcontinent that is the main moisture flux source for the southern Tibetan plateau. Increasing concentrations of black carbon causes a decrease in summer precipitation over the southern Tibetan plateau, resulting in 11.0% glacier deficit mass balance on average from 2007 to 2016; this loss rises to 22.1% in the Himalayas. The direct (accelerated melt) and indirect (mass supply decrease) effects of black carbon are driving the glacial mass decline of the so-called “Asian Water Tower”.
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
Authors: Kneppers Jeroen , Severson Tesa M. , Siefert Joseph C. , Schol Pieter , Joosten Stacey E. P. , Yu Ivan Pak Lok , Huang Chia-Chi Flora , Morova Tunç , Altıntaş Umut Berkay , Giambartolomei Claudia , Seo Ji-Heui , Baca Sylvan C. , Carneiro Isa , Emberly Eldon , Pasaniuc Bogdan , Jerónimo Carmen , Henrique Rui , Freedman Matthew L. , Wessels Lodewyk F. A. , Lack Nathan A. , Bergman Andries M. , Zwart Wilbert 
Published: November 2022

AbstractAndrogen receptor (AR) drives prostate cancer (PCa) development and progression. AR chromatin binding profiles are highly plastic and form recurrent programmatic changes that differentiate disease stages, subtypes and patient outcomes. While prior studies focused on concordance between patient subgroups, inter-tumor heterogeneity of AR enhancer selectivity remains unexplored. Here we report high levels of AR chromatin binding heterogeneity in human primary prostate tumors, that overlap with heterogeneity observed in healthy prostate epithelium. Such heterogeneity has functional consequences, as somatic mutations converge on commonly-shared AR sites in primary over metastatic tissues. In contrast, less-frequently shared AR sites associate strongly with AR-driven gene expression, while such heterogeneous AR enhancer usage also distinguishes patients’ outcome. These findings indicate that epigenetic heterogeneity in primary disease is directly informative for risk of biochemical relapse. Cumulatively, our results illustrate a high level of AR enhancer heterogeneity in primary PCa driving differential expression and clinical impact.
Post-covid medical complaints following infection with SARS-CoV-2 Omicron vs Delta variants
Authors: Magnusson Karin , Kristoffersen Doris Tove , Dell’Isola Andrea , Kiadaliri Ali , Turkiewicz Aleksandra , Runhaar Jos , Bierma-Zeinstra Sita , Englund Martin , Magnus Per Minor , Kinge Jonas Minet 
Published: November 2022

AbstractThe SARS-CoV-2 Omicron (B.1.1.529) variant has been associated with less severe acute disease, however, concerns remain as to whether long-term complaints persist to a similar extent as for earlier variants. Studying 1 323 145 persons aged 18-70 years living in Norway with and without SARS-CoV-2 infection in a prospective cohort study, we found that individuals infected with Omicron had a similar risk of post-covid complaints (fatigue, cough, heart palpitations, shortness of breath and anxiety/depression) as individuals infected with Delta (B.1.617.2), from 14 to up to 126 days after testing positive, both in the acute (14 to 29 days), sub-acute (30 to 89 days) and chronic post-covid (≥90 days) phases. However, at ≥90 days after testing positive, individuals infected with Omicron had a lower risk of having any complaint (43 (95%CI = 14 to 72) fewer per 10,000), as well as a lower risk of musculoskeletal pain (23 (95%CI = 2-43) fewer per 10,000) than individuals infected with Delta. Our findings suggest that the acute and sub-acute burden of post-covid complaints on health services is similar for Omicron and Delta. The chronic burden may be lower for Omicron vs Delta when considering musculoskeletal pain, but not when considering other typical post-covid complaints.
Solution-processed quantum-dot light-emitting diodes combining ultrahigh operational stability, shelf stability, and luminance
Authors: Ye Zi , Chen Mengyu , Chen Xingtong , Ma Wenchen , Sun Xiaojuan , Wu Longjia , Lin Xiongfeng , Chen Yu , Chen Song 
Published: November 2022

AbstractThe shelf-stability issue, originating from the ZnO-induced positive aging effect, poses a significant challenge to industrializing the display technology based on solution-processed quantum-dot light-emitting diodes (QLEDs). Currently, none of the proposed solutions can simultaneously inhibit exciton quenching caused by the ZnO-based electron-transporting layer (ETL) and retain other advantages of ZnO. Here in this work, we propose a bilayer design of ETL in which a buffer layer assembled of SnO2 nanoparticles (NPs) suppresses the QD-ETL exciton quenching and tunes charge balance while ZnO NPs provide high electron conductivity. As a result, the bottom-emitting QLED combining capped ZnO and SnO2 buffer exhibit a maximum luminance over 100,000 cd m−2 and a T95 operational lifetime averaging 6200 h at 1000 cd m−2 on the premise of entirely inhibiting positive aging.
Psychometric evaluation of the Depression Anxiety Stress Scale 8 among women with chronic non-cancer pelvic pain
Authors: Ali Amira Mohammed , Hendawy Amin Omar , Al-Amer Rasmieh , Shahrour Ghada , Ali Esraa M. , Alkhamees Abdulmajeed A. , Ibrahim Nashwa , Lamadah Sahar Mansour Taha , Ahmed Afaf Hassan 
Published: November 2022

AbstractPsychiatric comorbidity and abusive experiences in chronic pelvic pain (CPP) conditions may prolong disease course. This study investigated the psychometrics of the Depression Anxiety Stress Scale 8 (DASS-8) among women with CPP (N = 214, mean age = 33.3 ± 12.4 years). The DASS-8 expressed excellent fit, invariance across age groups and menopausal status, good know-group validity (differentiating women with psychiatric comorbidity from those without comorbidity: U = 2018.0, p = 0.001), discriminant validity (HTMT ratios < 0.85), excellent reliability (alpha = 0.90), adequate predictive and convergent validity indicated by strong correlation with the DASS-21 (r = 0.94) and high values of item-total correlations (r = 0.884 to 0.893). In two-step cluster analysis, the DASS-8 classified women into low- and high-distress clusters (n = 141 and 73), with significantly higher levels of distress, pain severity and duration, and physical symptoms in cluster 2. The DASS-8 positively correlated with pain severity/duration, subjective symptoms of depression/anxiety, experiences of sexual assault, fatigue, headache severity, and collateral physical symptoms (e.g., dizziness, bloating, fatigue etc.) at the same level expressed by the parent scale and the DASS-12, or even greater. Accordingly, distress may represent a target for early identification of psychiatric comorbidity, CPP severity, experiences of sexual assault, and collateral physical complaints. Therefore, the DASS-8 is a useful brief measure, which may detect mental distress symptoms among women with CPP.
Risk of malignancy in patients with psoriasis according to treatment modalities in Korea: a nationwide cohort study
Authors: Hong Ji Youn , Ahn Juhee , Won Sungho , Kim Sung Min , Cho Young Ah , Kim Chang Yong , Sung Jae Young , Yu Da-Ae , Lee Yang Won , Choe Yong Beom 
Published: November 2022

AbstractIntrinsic immunologic disparity of psoriasis itself, along with chronic inflammation and immunomodulatory anti-psoriatic treatments could be associated with increased risk of malignancy. We aimed to estimate the risk of malignancy in patients with psoriasis by treatment modality compared with that in individuals without psoriasis in Korea. We conducted a nationwide cohort study using the claims database of the National Health Insurance Service from January 2005 to December 2018. A total of 255,471 patients with psoriasis, and age- and sex-matched non-psoriasis participants (1:1 ratio) were enrolled. The adjusted hazard ratios (aHRs) [95% confidence intervals (CIs)] for malignancy without nonmelanoma skin cancer (NMSC) were 1.10 [1.08–1.12] in patients with psoriasis, 1.13 [1.00–1.27], 1.05 [0.97–1.13], and 1.24 [0.84–1.83] in phototherapy, non-biologic systemics, and biologics cohort, respectively. Among the non-biologic systemics cohort, patients treated with cyclosporin showed higher risk of malignancy without NMSC (aHR [95% CI], 1.20 [1.04–1.39]). The risk of malignancy without NMSC in patients with psoriasis was higher than that in individuals without psoriasis. Phototherapy and biologics were not associated with significant increase of risk; however, cyclosporin appeared to increase its risk. Dermatologists should be vigilant about this potential risk while managing patients with psoriasis.