bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIFITAS PENGGUNAAN DIAGRAM PUTAR DAN BUKU SAKU MKJP TERHADAP PENGETAHUAN AKSEPTOR
Authors: Ruwayda Ruwayda , Defirson Defirson 
Published: February 2022

MKJP merupakan metode kontrasepsi jangka panjang yang sesuai dengan keadaan pandemi dimana mengurangi kontak secara rutin dengan petugas kesehatan. Akan tetapi, penggunaan KB MKJP yaitu IUD di bulan Februari 2020 sebanyak 36.155 akseptor turun menjadi 23.383 akseptor di bulan Maret 2020. Sedangkan untuk alat kontrasepsi Implan juga menurun dari 81.062 akseptor di bulan Februari menjadi 51.536 akseptor di bulan Maret. Proporsi MKJP yang rendah tidak hanya secara nasional tetapi juga terjadi di Provinsi Jambi. Tujuan penelitian ini adalah untuk melihat efektiftas penggunaan diagram putar dan buku saku MKJP terhadap pengetahuan akseptor. Metode penelitian quasi eksperimen dengan rancangan Two Group Pretest Posttest Penelitian dilaksanakan Januari-September 2021 Populasi semua akseptor KB yang berkunjung ke Puskesmas Putri Ayu tahun 2021. Data diperoleh melalui kuesioner pre test dan post test. Hasil penelitian ini menunjukkan sebelum penggunaan diagram putar dan buku saku MKJP sebagian besar responden memiliki pengetahuan yang kurang dan sesudah penggunaan memiliki pengetahuan yang baik. Tidak ada perbedaan efektivitas penggunaan diagram putar dan buku saku MKJP terhadap Pengetahuan Akseptor karena kedua intervensi memiliki nilai p 0,000 0,05. Disarankan melakukan promosi kesehatan menggunakan diagram putar dan buku saku MKJP untuk meningkatkan keikutsertaan Pasangan Usia Subur.
Predictive biomarkers of immune-related adverse events
Authors: Zhukova Natalia , Orlova Rashida , Malkova Anna , Kaledina Ekaterina , Beliak Natalia 
Published: February 2022

Taking into account widespread use of check-point inhibitors in real clinical practice, pharmacoeconomic issues, the incidence and grade of immune-related adverse events, there is an urgent need for using prognostic and predictive biomarkers of toxicity of immunotherapy. This review presents a literature review of the databases such as PubMed, MEDLINE, Google Scholar, Springer. Articles were searched using the keywords: “predictive biomarkers of toxicity”, “immunotherapy”, “predictive markers of immune-related adverse events”. Subsequently the information obtained was analyzed in order to define possible predictive biomarkers of immune-related toxicity that could be used in real clinical practice.
Direct Estimate of the Post-Newtonian Parameter and Cosmic Curvature from Galaxy-scale Strong Gravitational Lensing
Authors: Wei Jun-Jie , Chen Yun , Cao Shuo , Wu Xue-Feng 
Published: February 2022

Abstract
Einstein’s theory of general relativity (GR) has been precisely tested on solar system scales, but extragalactic tests are still poorly performed. In this work, we use a newly compiled sample of galaxy-scale strong gravitational lenses to test the validity of GR on kiloparsec scales. In order to solve the circularity problem caused by the presumption of a specific cosmological model based on GR, we employ the distance sum rule in the Friedmann–Lemaître–Robertson–Walker metric to directly estimate the parameterized post-Newtonian (PPN) parameter γ
PPN and the cosmic curvature Ω
k
by combining observations of strong lensing and Type Ia supernovae. This is the first simultaneous measurement of γ
PPN and Ω
k
without any assumptions about the contents of the universe or the theory of gravity. Our results show that

γ

PPN

=

1.11

−
0.09

+
0.11

and

Ω

k

=

0.48

−
0.71

+
1.09

, indicating a strong degeneracy between the two quantities. The measured γ
PPN, which is consistent with the prediction of 1 from GR, provides a precise extragalactic test of GR with a fractional accuracy better than 9.0%. If a prior of the spatial flatness (i.e., Ω
k
= 0) is adopted, the PPN parameter constraint can be further improved to

γ

PPN

=

1.07

−
0.07

+
0.07

, representing a precision of 6.5%. On the other hand, in the framework of GR (i.e., γ
PPN = 1), our results are still marginally compatible with zero curvature (

Ω

k

=
−

0.12

−
0.36

+
0.48

), supporting no significant deviation from a flat universe.
Modeling the Distribution of Organic Carbon and Nitrogen in Impact Crater Melt on Titan
Authors: Hedgepeth Joshua E. , Buffo Jacob J. , Chivers Chase J. , Neish Catherine D. , Schmidt Britney E. 
Published: February 2022

Abstract
Titan is a chemically rich world that provides a natural laboratory for the study of the origin of life. Titan’s atmospherically derived C
x
H
y
N
z
molecules have been shown to form amino acids when mixed with liquid water, but the transition from prebiotic chemistry to the origin of life is not well understood. Investigating this prebiotic environment on Titan is one of the primary motivations behind NASA’s Dragonfly mission. One of its objectives is to visit the 80 km diameter Selk crater, where a melt sheet of liquid water would have formed during the impact cratering process. Organic molecules on Titan’s surface could have mixed with this water, forming molecules of prebiotic interest. Constraining how this material becomes trapped in the refreezing ice is necessary for Dragonfly to effectively target and interpret the samples it aims to acquire. In this work, we adapt the planetary ice model of Buffo et al. to Titan conditions to track how organic molecules will become trapped within the ice of the freezing melt sheet. We use HCN as a model impurity because of its abundance on Titan and its propensity to form amino acids in aqueous solutions. We show that without hydrolysis, HCN will be concentrated in the upper and middle portions of the resolidified melt sheet. In a closed system like Selk crater, the highest concentration of HCN appears 75% of the way into the frozen melt pond (relative to the surface), but HCN should be accessible at high concentrations nearer the surface as well.
Empirical Photochemical Modeling of Saturn’s Ionization Balance Including Grain Charging
Authors: Vigren E. , Dreyer J. , Eriksson A. I. , Johansson F. L. , Morooka M. , Wahlund J.-E. 
Published: February 2022

Abstract
We present a semianalytical photochemical model of Saturn’s near-equatorial ionosphere and adapt it to two regions (∼2200 and ∼1700 km above the 1 bar level) probed during the inbound portion of Cassini’s orbit 292 (2017 September 9). The model uses as input the measured concentrations of molecular hydrogen, hydrogen ion species, and free electrons, as well as the measured electron temperature. The output includes upper limits, or constraints, on the mixing ratios of two families of molecules, on ion concentrations, and on the attachment rates of electrons and ions onto dust grains. The model suggests mixing ratios of the two molecular families that, particularly near ∼1700 km, differ notably from what independent measurements by the Ion Neutral Mass Spectrometer suggest. Possibly connected to this, the model suggests an electron-depleted plasma with a level of electron depletion of around 50%. This is in qualitative agreement with interpretations of Radio Plasma Wave Science/Langmuir Probe measurements, but an additional conundrum arises in the fact that a coherent photochemical equilibrium scenario then relies on a dust component with typical grain radii smaller than 3 Å.
The Relationship between Stunting and Tooth Eruption of Primary School Children at Tuah Negeri Sub-district, Musi Rawas District, South Sumatera Province, Indonesia
Authors: Zulkarnain Mohammad , Sitorus Rico Januar , Appulembang Yeni Anna , Jasmine Annisah Biancika , Lutfi Abubakar 
Published: February 2022

BACKGROUND: Stunting is a condition where the body height is shorter than normal, unproportioned to the child age, caused by lack of nutrition and/or caused by repeated disease in a long time period since the development of fetus until the first two years of life. The University of Alabama at Birmingham Health System states that Calcium, Phosphorus, vitamin C and vitamin D intake are extremely important so that lack of those nutrient can prohibit body growth and tooth development and eruption. Tuah Negri Sub-district at Musi Rawas District, South Sumatra Province, Indonesia is one of sub-district in Indonesia with high prevalence of stunting event.

AIM: This research was performed to proof that there is an association between stunting and tooth eruption of primary school children at Tuah Negeri Sub-district, Musi Rawas District, South Sumatera Province, Indonesia.

METHODS: The research employed a quantitative research design with a cross-sectional analytical survey method. Nutritional status was examined anthropometrically to identify stunting event. Tooth examination was performed among 94 students of 5 purposively selective primary schools based on their high prevalence of stunting cases. The results were then put into the odontogram.

RESULTS: The results of the study showed that there were 31 children with stunting (33.0%), which is higher than the national data, and 21 of those with the stunting (67.7%) were identified as having delayed tooth eruption. Statistical examination using chi-squared test showed that the proportion of children with delayed tooth eruption was significantly higher among children with stunting compared to those without stunting, with p-value 0.034 and odds ratio (OR) 2.63 (95% C.I. = 1.7 – 6.5).

CONCLUSION: There is an association between stunting and tooth eruption of primary school children at Tuah Negeri Sub-district, Musi Rawas District, South Sumatera Province, Indonesia. Children with stunting have 2.63 times higher possibility to experience delayed tooth eruption compared with those without stunting
Correlation of Fetal Growth Between Last Menstrual Period and third Trimester Ultrasound Pregnancy on Ethnic Minangkabau
Authors: Yusrawati Yusrawati , Serudji Joserizal , Utama Bobby Indra , Sari Puspita 
Published: February 2022

BACKGROUND: Fetal growth is a vital thing that determines the quality of life at birth. Because the multinational studies available today represent a very limited choice of a varied world population.
AIM: this study is expected to provide results in the form of more parameters. accurate in determining fetal growth estimates.
MATERIAL AND METHODS: This study is an analytical study using a cross sectional approach determine fetal growth biometry in the Minangkabau ethnic group. The selected sample was pregnant women who came to check their pregnancy in December 2020 at Fetomaternal clinic Hospital M. Djamil Padang and Network Hospital in the Department of Obstetrics and Gynecology Faculty of Medicine Andalas University. Bivariate analysis using Pearson correlation test because the data distribution was normally distributed with P value <0,05 and then multivariate analysis using linear regression.
RESULTS: Five hundred and twenty pregnant women who came to check at 3rd trimester (28-40 weeks by US). The characteristics of the research subjects were the average age of pregnant women ranging from 21-39 years with the average was 28.49 ± 4.5 years, parity 1 as many as 203 people (46,7%), and the average level of education at senior high school as many as 431 people (82,9%), and there were 123 working pregnant women (42,5%). Based on the Pearson analysis, Correlation between of each variable BPD, HC, AC, FL, and HL to LMP, there is the strongest correlation between LMP and AC, which is r = 0,799 and the weakest correlation between LMP and HL is r = 0,162, for all variables is very significant (p value 0,000). The multivariate analysis with linear regression, there is a significant value that the simultaneous measurement of biometric variables (BPD, HC, AC, FL, HL) on the LMP would be 84.6% more significant.
CONCLUSIONS: There is a significant correlation fetal growth between LMP and 3rd trimester ultrasound pregnancy with variable BPD, HC, AC, FL, HL on minangkabau ethnic
L’implantation d’un dispositif d’inclusion en collège : appropriation singulière dans un cadre collectif
Authors: Savournin Florence , Brossais Emmanuelle , Chevallier-Rodrigues Émilie , Courtinat-Camps Amélie , de Léonardis Myriam 
Published: February 2022

Cet article vise la compréhension des problématiques liées à l’École inclusive dans une perspective collaborative. Trois focus group ont été menés auprès d’enseignants, de personnels de vie scolaire et administratifs pour saisir l’expérience de l’inclusion de professionnels de collège, lors de l’implantation d’un dispositif Ulis. Nous adoptons une double approche théorique : clinique analytique des processus éducatifs et psychologie du développement. Les processus d’appropriation se traduisent d’une part par des controverses, de l’ambivalence, des paradoxes exprimés dans la dynamique interactive. Ces interrogations et réflexions relèvent de modifications des représentations et des pratiques professionnelles. Et d’autre part, une diversité de modalités d’appropriation subjective révèlent des positionnements singuliers liés à la rencontre et à l’accueil de l’autre différent, allant de mécanismes de défense à l’invention de nouvelles pratiques.
Phase I Trial Characterizing the Pharmacokinetic Profile of N-803, a Chimeric IL-15 Superagonist, in Healthy Volunteers
Authors: Rubinstein Mark P , Williams Cameron , Mart Caroline , Beall Jonathan , MacPherson Linda , Azar Joseph , Swiderska-Syn Marzena , Manca Paolo , Gibney Barry C , Robinson Mark D , Krieg Carsten , Hill Elizabeth G , Taha Sharif A , Rock Amy D , Lee John H , Soon-Shiong Patrick , Wrangle John 
Published: February 2022

Abstract
The oncotherapeutic promise of IL-15, a potent immunostimulant, is limited by a short serum t1/2. The fusion protein N-803 is a chimeric IL-15 superagonist that has a &gt;20-fold longer in vivo t1/2 versus IL-15. This phase 1 study characterized the pharmacokinetic (PK) profile and safety of N-803 after s.c. administration to healthy human volunteers. Volunteers received two doses of N-803, and after each dose, PK and safety were assessed for 9 d. The primary endpoint was the N-803 PK profile, the secondary endpoint was safety, and immune cell levels and immunogenicity were measures of interest. Serum N-803 concentrations peaked 4 h after administration and declined with a t1/2 of ∼20 h. N-803 did not cause treatment-emergent serious adverse events (AEs) or grade ≥3 AEs. Injection site reactions, chills, and pyrexia were the most common AEs. Administration of N-803 was well tolerated and accompanied by proliferation of NK cells and CD8+ T cells and sustained increases in the number of NK cells. Our results suggest that N-803 administration can potentiate antitumor immunity.
BK Polyomavirus Hemorrhagic Cystitis in Hematopoietic Cell Transplant Recipients
Authors: Lionel Sharon Anbumalar , Abraham Aby , Mathews Vikram , Lakshmi Kavitha , Abraham Asha Mary , George Biju 
Published: February 2022

Introduction:
BK polyomavirus-associated hemorrhagic cystitis (BKPyV-HC) is a well-recognized infective complication of hematopoietic cell transplant (HCT) with increased organ dysfunction and mortality. This study was performed to describe the local incidence, risk factors, and outcomes of BKPyV infection.

Methods:
This retrospective case–control study was conducted between 2007 and 2016 from a tertiary hospital in South India. We identified HCT recipients diagnosed with BKPyV-HC and compared them with recipients over the same period who did not develop BK virus infection matched for age, sex, diagnosis, and donor type. We collected data from central electronic medical records and databases maintained in the departments of hematology and virology.

Results:
Over the study period, 1276 transplants were performed, of which 262 patients (20.5%) developed HC and 105 (8.2%) were BKPyV-positive. Grade 3 HC was most commonly (57.1%) seen, and the median time to develop BKPyV-HC was 35 (range 0–858) days. Survival was significantly lower in the cases (42.9% vs. 61%, P < 0.05). On univariate analysis, the protective effect of nonmyeloablative conditioning (P = 0.04), residual disease at the time of transplant in malignant conditions (P = 0.001), lower CD34 dose (P = 0.006), presence of acute graft versus host disease (GVHD, P < 0.001), reactivation of cytomegalovirus infection (P < 0.001), and presence of bacterial urinary tract infection (UTI) (P < 0.001) were significant factors. Multivariate logistic regression confirmed the presence of acute GVHD (P = 0.041), bacterial UTI (P < 0.001), and residual disease (P = 0.009) at HCT as significant risk factors for BKPyV-HC.

Conclusions:
Our study affirms the homogeneity of BKPyV-HC disease in low- and middle-income HCT settings with prior reports and the need for therapeutic strategies to reduce its resultant mortality.
Assessment of Hepatitis B and Hepatitis C Status in Children with Chronic Kidney Disease
Authors: Ara Jannat 
Published: February 2022

Background:
Children with chronic kidney disease (CKD) are immunocompromised and they are more prone to develop hepatitis B and hepatitis C virus infections.

Objective:
The aim of this study was to evaluate the status of hepatitis B and hepatitis C in children with CKD.

Study Design:
This was a cross-sectional study.

Study Setting and Period:
This study was conducted at the Department of Pediatrics Nephrology, Dhaka Shishu (Children) Hospital, from February 2019 to July 2019.

Study Population:
Children aged 6 months–18 years with the diagnosis of CKD participated in the study.

Materials and Methods:
A total of 35 purposively selected patients with CKD were enrolled. Thorough history, physical examination, and necessary investigations were done. CKD staging was done by using the revised Schwartz formula. All 35 patients were in CKD stages 3–5. They were divided into three groups: CKD stage 3–4; CKD stage 5 pre-hemodialysis (pre-HD); and CKD stage 5 maintenance HD. Then hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (anti-HCV), and hepatitis B surface antibody (anti-HBs) titer were assessed in all patients and compared between the groups. Analysis was done by the analysis of variance (ANOVA) and t test. A value of P < 0.05 was considered statistically significant.

Results:
The study revealed that all 35 patients were negative for HBsAg and anti-HCV. Anti-HBs antibody titer in 25.7% patients were 00 mIU/mL, in 40% patients <10 mIU/mL, in 20% patients 10–100 mIU/mL, and in 14.3% patients >100 mIU/mL. Majority (65.7%) of the patients had no protection (titer 0–<10 mIU/mL) against hepatitis B virus (HBV) infection and seen declining of anti-HBs antibody titer with increase of age in the study population. No significant difference of antibody titer was found in between gender, cause of CKD, different stages of CKD, and duration of the disease.

Conclusion:
In this study, all patients with CKD were negative for HBsAg and anti-HCV. Patients were negative for HBsAg. However, majority (65.7%) of patients show no protection against HBV infection.
Liver Disease Outcomes after Sustained Virological Response in Patients with Chronic Hepatitis C Infection Treated with Generic Direct-Acting Antivirals
Authors: Abd El-Wahab Ekram W. , Abd Elgawad Waleed M. , Said Mohamed , Mikheal Ashraf I. , Shatat Hanan Z. 
Published: February 2022

ABSTRACT.
The introduction of generic direct-acting antivirals (DAAs) in Egypt is associated with a superior cure rate of hepatitis C virus (HCV) infection. However, the course of progressive liver damage and developing liver related complications in patients with sustained virologic response (SVR) remain unclear. This study was designed to examine the long-term outcomes of generic DAA-induced virological cure in a real-life cohort of HCV patients with or without comorbid schistosomiasis. We prospectively enrolled a cohort of 506 recently cured HCV patients (437 Child–Pugh class A [Child-A] and 69 Child–Pugh class B [Child-B]). All patients were clinically evaluated at different time points during a 2-year follow-up (November 2018 to February 2021). Over the course of treatment and follow-up, 77 (15.2%) patients (42 [9.6%] Child-A and 35 [50.7%] Child-B) experienced complications at different time points. The overall mortality rate was approximately 1/1,000 person-years. The incidence of hepatic insufficiency was approximately 5.5/1,000 person-years, and that of de novo hepatocellular carcinoma (HCC) was approximately 8.3/1,000 person-years. A sustained improvement in liver indices up to 2 years of follow-up was observed. In the Cox regression model, pretreatment decompensated cirrhosis predicted the occurrence of adverse liver events and HCC after therapy. In conclusion, in HCV patients with advanced cirrhosis or coexisting hepatic schistosomiasis, generic DAA-induced SVR remains robust with favorable clinical outcomes although the risk of hepatocarcinogenesis cannot be eliminated. Surveillance of patients with treated HCV infection is an important aspect of postcure care for early detection and management of liver disease-related adverse events.
Evaluation of genetic variability in Brahman cattle breed in Malaysia using microsatellite markers
Authors: Abdelwahid Haytham Hago , Panandam Jothi M , Sharma Reuben .S.K , Yaakub Halimatun 
Published: February 2022

The Brahman was one of the exotic breeds imported into Malaysia to help boost the local beef cattle industry. Due to its adaptability and the productive performance, it is considered as a suitable breed for the country, as well as a breed for use in crossbreeding. This study aimed to assess the genetic variability in the Brahman breed in Malaysia using microsatellite markers. Twenty microsatellite loci,BM1818, BM1824, BM2113, CSRM60, CSSM66, ETH3, ETH10, ETH152, ETH185, ETH225, HAUT24, HAUT27, HEL1, HEL5, HEL9, HEL13, ILSTS005, ILSTS006, INRA005 and INRA023, were used to screen a random sample of 32 of Brahman cattle at the Brahman nucleus herd at DVS Livestock Center in Kuala Berang, Terengganu. A total of 151 alleles were detected. The number of alleles per locus varied between 6 and 10 with an average of 7.6. The effective number of alleles (Ne) range between 2 and 7 with average of 3.8. The observed heterozygosity values (0.26 - 0.83) were lower than the expected heterozygosity values for almost all loci. The overall mean heterozygosity was 0.54. The values of inbreeding coefficient (FIS) based on the individual locus were generally positive. Thirteen loci deviated from HWE equilibrium (p<0.05). This study showed that there was low genetic variability in the Brahman nucleus herd in Malaysia
Cytotoxic and antioxidant effect of the ethanolic extract of Citrullus colocynthis L. plant fruit
Authors: Fetni Samira , Bertella Nabil 
Published: February 2022

Citrullus colocynthis L. of the Cucurbitaecea botanical family is a plant widely used in traditional medicine in Algeria. It seems empirically effective in the treatment of various diseases. The aim of the present research is to evaluate the antioxidant and cytotoxic effects, in vitro, of the ethanolic extract of C. colocynthis fruits. The quantitative analysis has shown that the ethanolic extract of C. colocynthis is rich in total polyphenols with a content of 443.62 ± 2.13 µg EAG/mg of extract. The results obtained showed a strong anti-free radical activity of the ethanolic extract of C.colocynthis exerted against the DPPH free radical scavenging effect (CI50 = 6.31 µg/ml) and highlighted a powerful ferric reducing antioxidant power (CI50 = 27.94 µg/ml). We should also note a good antioxidant activity against the OH radical, obtained with the concentration (IC50 = 67.13 µg/ml). Furthermore, the obtained results indicate that the treatment of the three cancer cell lines (HepG2, SH-SY5Y and Raw 264.7) with the different concentrations of the used extract reduced the number of cells in a dose-dependent way. Based on our results, we can consider that Citrullus colocynthis is a plant with a strong pharmacological power and can therefore be used in phytotherapy.