bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study
Authors: Wang Yuxi , Chew Qian Hui , Lin Shih-Ku , Yang Shu-Yu , Ouyang Wen-Chen , Chen Chih-Ken , Park Seon-Cheol , Jang Ok-Jin , Park Jun Hyuk , Chee Kok-Yoon , Ding Kwong Sen , Chong Jamaline , Zhang Ling , Li Keqing , Zhu Xiaomin , Jatchavala Chonnakarn , Pariwatcharakul Pornjira , Kallivayalil Roy Abraham , Grover Sandeep , Avasthi Ajit , Ansari Moin , Maramis Margarita M. , Aung Paing Phyo , Sartorius Norman , Xiang Yu-Tao , Tan Chay-Hoon , Chong Mian-Yoon , Park Yong Chon , Kato Takahiro A. , Shinfuku Naotaka , Baldessarini Ross J. , Sim Kang 
Published: April 2022

Abstract

Background
Because use and dosing of mood stabilizers (MSs) to treat bipolar disorder (BD) patients in Asia are not well documented, we examined prevalence and clinical correlates of treatment of Asian BD patients with relatively high doses of MSs.

Methods
We conducted a pharmacoepidemiological survey across 13 Asian countries and territory in the Research on Asian Psychotropic Prescription Patterns Consortium. Mood stabilizer doses were converted to lithium carbonate equivalents (Li-eq milligrams per day). We compared relatively high (>900 Li-eq mg/day) versus lower MS doses by bivariate comparisons, followed by multivariable linear regression to identify factors associated with higher MS doses.

Results
Among 1647 participants, MS dose averaged 584 (confidence interval, 565–603 Li-eq mg/d). Preliminarily, the 13.1% of the subjects given greater than 900 mg/d versus those given lower doses were younger, male, currently hospitalized, not currently depressed, and reported lifetime suicidal ideation; they also received relatively high doses of antipsychotics, received electroconvulsive treatment within the previous 12 months, and had greater ratings of tremors and sedation. By linear regression modeling, the mean proportion given high doses of MS was associated significantly and independently with higher doses of antipsychotics, younger age, male sex, hospitalized, more years of illness, country, higher body mass index, recent electroconvulsive treatment, and being in illness remission.

Conclusions
Relatively high doses of MSs for BD are prevalent, but vary markedly among Asian countries, and are particularly likely among young males, ill for many years, and given high doses of antipsychotics or ECT. These characteristics allow better identification of patient profiles that can guide treatment of BD patients.
Supporting Parents Through a Cleft Palate
Authors: Binford Leslie , Rice Mary Eve , Hamlin Amy , Wilson Debra Rose 
Published: April 2022

Abstract
The diagnosis of cleft anomalies evokes many emotions for parents, creating a significant psychosocial burden and ripple effect on the family. Parents report feeling fearful after diagnosis and overwhelmed on how to care for their child. They feel unprepared to manage the social response to a visible congenital malformation such as cleft lip and palate. Parents of children born with congenital malformations such as cleft palate have many obstacles to overcome in their child's lifetime, but many do not even know where to begin. Support for parents of children with palate should begin at diagnosis, as it takes time for these families to process how their child's congenital malformation will affect the quality of life of the family and the child. This article reviews the ways healthcare teams can support parents through diagnosis, coping, feeding, and surgical experiences and provides resources for providing care for these families.
Nurse practitioner preceptor education to increase role preparedness
Authors: Perryman Ka’Shiris W. 
Published: April 2022

ABSTRACT

Background:
The public has become aware of the need for nurses and nurse practitioners in primary care with the widespread public health crisis. As the need for nurses and nurse practitioners grows, there is a need for the clinical educator and preceptor. However, preceptors have noted barriers to precepting such as time constraints, lack of preceptor role education, and role preparedness.

Local problem:
Currently, neither preceptor role development nor education has been implemented within a local institution. Preceptor vocalization led the charge for preceptor role development education within the institution.

Methods:
This quality improvement project focused on the preceptor role preparedness and education. A convenience sample was recruited from a large, diverse academic institution. The modified Clinical Supervision Self-Assessment Tool-Skills was utilized to determine the effectiveness of online education in preceptor role preparedness.

Interventions:
An online, self-directed, evidence-based preceptor education webpage with easily reproducible information related to collaborating with students and faculty situations. Literature, such as the One Minute Preceptor, Ask, Tell, Ask, and engaging student scenarios, was included from the literature review. A voice-recorded PowerPoint summarizing the webpage was included with a transcript for accessibility.

Results:
A paired t-test was used to assess the mean differences between the preintervention and postintervention periods. The results indicated the online preceptor education was effective.

Conclusions:
Preparing nurse practitioner preceptors for their roles benefits the health care system. An online, self-directed, evidence-based preceptor education webpage can be beneficial in future preceptor education planning.
PedBotHome: A Video Game–Based Robotic Ankle Device Created for Home Exercise in Children With Neurological Impairments
Authors: Coley Catherine , Kovelman Staci , Belschner Justine , Cleary Kevin , Schladen Manon , Evans Sarah Helen , Salvador Tyler , Monfaredi Reza , Fooladi Talari Hadi , Slagle Jacob , Rana Md Sohel 
Published: April 2022

Purpose:
This pilot study assesses the feasibility of using PedBotHome to promote adherence to a home exercise program, the ability of the device to withstand frequent use, and changes in participant ankle mobility.
PedBotHome is a robotic ankle device with integrated video game software designed to improve ankle mobility in children with cerebral palsy.

Methods:
Eight participants enrolled in a 28-day trial of PedBotHome. Ankle strength, range of motion, and plantar flexor spasticity were measured pre- and posttrial. Performance was monitored remotely, and game settings were modified weekly by physical therapists.

Results:
Four participants met the study goal of 20 days of use. There were statistically significant improvements in ankle strength, spasticity, and range of motion.

Conclusions:
PedBotHome is a feasible device to engage children with static neurological injuries in ankle home exercise. This pilot study expands the paradigm for future innovative home-based robotic rehabilitation.
Incorporating Holistic Review in Recruitment in a Physical Medicine and Rehabilitation Residency Program
Authors: Chi Bradley , Krull Christine , Akamagwuna Unoma , Huang Donna 
Published: April 2022

Abstract
Traditional residency recruitment practices are vulnerable to unconscious biases, inequity, lack of diversity, and have limited ability to predict future clinical competency. Holistic review and evidence-based strategies, such as structured interviews and situational judgment tests, can mitigate these limitations. A physical medicine and rehabilitation residency program restructured its residency recruitment process using holistic review principles and evidence-based strategies during the 2020–2021 academic year. A subcommittee developed a weighted screening rubric based on Association of American Medical Colleges core competencies and semistructured interview questions targeting specific domains. Formal implicit bias training was provided. Screening scores determined interview invitations. Applicants participated in three different domain-focused semistructured interviews. Screening and interview scores were combined to form the program rank list. A postinterview anonymous questionnaire was sent to interviewees to obtain feedback. Four hundred eighty-nine applicants were screened (82 interview invitations, 80 interviewed, 8 matched). The respondents to the postinterview questionnaire found that interviews evaluated them objectively (90%) and improved their impression of the program (90%). The program’s match was consistent with previous matches. Interviewed applicants represented a racially diverse group. Most questionnaire respondents had a positive impression of the interview process. This article demonstrates incorporating holistic review into residency recruitment and provides specific resources to aid other institutions pursuing similar goals.
18F-Labeled WBC PET/CT Scan in a Case of Recurrent Glioblastoma Multiforme, Presented as Pyrexia of Unknown Origin
Authors: Das Subha Shankar , Malik Dharmender , Khanna Gaurav , Sen Ishita Bharat , Patir Rana 
Published: April 2022

Abstract
Neoplastic causes account for approximately 10% to 20% cases of PUO (pyrexia of unknown origin). The mechanisms by which malignancies induce fever are not fully understood. The release of pyrogenic cytokines either directly from tumor cells or from macrophages responding to tumor are likely to play a major role, which acts on the hypothalamus, causing a change in the thermostatic set point. We present a case of recurrent glioblastoma multiforme, who presented with PUO. 18F-FDG–labeled leukocyte PET/CT scan done for localization of infective focus demonstrated significant tracer accumulation at the periphery of the recurrent brain lesion. Subsequent excisional biopsy from the lesion was suggestive of noninfected recurrent glioblastoma multiforme.
Detecting Interval Distant Metastases With 18F-FDG PET/CT After Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Cancer
Authors: Kroese Tiuri E. , Ruurda Jelle P. , Bakker Anne S. , Jairam Jasvir , Mook Stella , van der Horst Sylvia , Meijer Gert J. , Haj Mohammad Nadia , van Rossum Peter S.N. , van Hillegersberg Richard 
Published: April 2022

Purpose
Patients with esophageal cancer can develop distant metastases between the start of neoadjuvant chemoradiotherapy (nCRT) and planned surgery (ie, interval distant metastases). 18F-FDG PET/CT restaging after nCRT detects interval distant metastases in ~8% of patients. This study aimed to identify patients for whom 18F-FDG PET/CT restaging after nCRT could be omitted using an existing prediction model predicting for interval distant metastases or by using clinical stage groups.

Patients and Methods
Patients with locally advanced esophageal cancer who underwent baseline and restaging 18F-FDG PET/CT, nCRT, and were planned for esophagectomy between 2017 and 2021 were eligible for inclusion in this retrospective study. The primary outcome was the existing model’s external performance (ie, discrimination and calibration) for predicting interval distant metastases. The existing model predictors included tumor length, cN status, squamous cell carcinoma histology, and baseline SUVmax. The secondary outcome determined the clinical stage groups (AJCC/UICC eighth edition) for adenocarcinoma and squamous cell carcinoma for which the incidence of interval distant metastases was <10%.

Results
In total, 127 patients were included, of whom 17 patients developed interval distant metastases (13%; 95% confidence interval [CI], 8%–21%) and 9 patients were deemed to have false-positive lesions on 18F-FDG PET/CT (7%; 95% CI, 2%–11%). Applying the existing model to this cohort yielded a discriminatory c-statistic of 0.56 (95% CI, 0.40–0.72). The calibration of the existing model was poor (ie, mostly underestimating the actual risk). The incidence of true-positive versus false-positive interval distant metastases for patients with clinical stage II disease was 5% versus 0%; clinical stage III, 14% versus 8%; and clinical stage IVa, 22% versus 9%.

Conclusions
The existing prediction model cannot reliably identify patients at risk for developing interval distant metastases after nCRT for esophageal cancer. Omission of 18F-FDG PET/CT restaging after nCRT could be considered in patients with clinical stage II esophageal cancer.
Second infection with SARS-CoV-2 wild-type is associated with increased disease burden after primary SARS-CoV-2/HBoV-1 coinfection, Cologne, Germany
Authors: Windisch Wolfram , Brockmann Michael , Demuth Sabrina , Lüsebrink Jessica , Schildgen Verena , Schildgen Oliver 
Published: April 2022

SARS-CoV-2 is the cause of the still-ongoing COVID-19 pandemic. To date reports on re-infections after full recovery from a previous COVID-19 course remain limited due to the fact that re-infections or second infections occur at the earliest between 3 to 24 months after full recovery while the pandemic lasts only since a year. Even less data are available on re-infections associated with emerging variants.
A 33-year-old previously healthy male patient was tested twice SARS-CoV-2 RNA positive with an 8 months symptom-free interval between the two COVID-19 episodes in our setting in Cologne, Germany. While the first episode was accompanied by a co-detection of human bocavirus and hardly any symptoms, the second episode was characterized by serious illness and severe flu-like symptoms, although hospitalization was not required. After the first episode no residual viral RNA was detected after the patient was released from quarantine. Follow up of the patient revealed a moderate but significant reduction of the lung volume and slightly impaired diffusion capacity.

Conclusion. While it is known that re-infections with SARS-CoV-2 may occur this is the first report of a co-detection of human bocavirus (HBoV) during a primary SARS-CoV-2 infection. The first, hardly symptomatic episode showed that co-infections do not necessarily initiate severe COVID-19 courses. The second more severe episode with serious flu-like symptoms could be explained by the sustained mild damage of the airways during the primary infection.
Consequences of CSR reporting regulations worldwide: a review and research agenda
Authors: Haji Abdifatah Ahmed , Coram Paul , Troshani Indrit 
Published: April 2022

PurposeThis study reviews research that examines economic and behavioural consequences of CSR reporting regulations. Specifically, the authors evaluate the impact of CSR reporting regulations on (1) reporting quality, (2) capital-markets and (3) firm behaviour.Design/methodology/approachThe authors first describe the stated objectives and enforcement level of CSR reporting regulations around the world. Second, the authors review over 130 archival studies in accounting, finance, economics, law and management that examine consequences of the regulations.FindingsThe stated objectives and enforcement of CSR reporting regulations vary considerably across countries. Empirical research finds no significant changes in reporting quality and generally concludes that CSR reporting continues to be ceremonial rather than substantive after the regulations – consistent with corporate legitimation and “greenwashing” views. In contrast, growing evidence shows both positive and negative capital-market and real effects of the regulations. Overall, the findings from this review indicate that, on balance, there remains a significant number of questions on the net effects of CSR reporting regulations.Originality/valueThe authors offer a comprehensive review of the literature examining consequences of CSR reporting regulations. The authors identify apparent tensions in studies assessing different outcomes after the regulations: between symbolic reporting and positive capital-market outcomes; between profitability and CSR; and between CSR and the welfare of non-shareholder groups. Additionally, we highlight differences in the scope and stated objectives of CSR regulations across countries, with the regulations often reflecting socio-economic development and national interests of implementing countries. Collectively, our review indicates that institutional details are crucial when considering the design or consequences of CSR reporting regulations and/or standards.
The interdependence of foreign exchange vulnerability in emerging markets
Authors: Qureshi Saba , Aftab Muhammad , Hegerty Scott 
Published: April 2022

PurposeThe foreign exchange market plays a crucial role in defining the overall health of an economy. In these times of globalization and (in some ways) deglobalization, these markets are highly vulnerable to external shocks. In this line of research, this study investigates exchange-market vulnerability among the BRICS economies by considering the co-movements among variables and contagion among markets.Design/methodology/approachThis study uses DCC-IGARCH and Wavelet approaches to examine interdependence and contagion among the foreign exchange markets of the BRICS countries. The prior approach gives exposure to correlations over time, while the latter approach is suitable to provide insight regarding correlations over different frequency and time domains.FindingsThese results show evidence of meaningful co-movements in the vulnerability of the BRICS economies' foreign exchange markets during periods of market instability. The authors observe that interdependence significantly increased after 2008 and is prominent in the short run, particularly up to the scale of 1.5 years. In addition, there is evidence of persistent integration across the short and medium run. Furthermore, the findings indicate recurrent patterns of co-movements and the presence of contagion.Originality/valueGiven the high degree of economic integration among the BRICS economies, there is relatively little literature on how each member country's foreign exchange vulnerability can affect others. This research fills this gap, by applying appropriate econometric techniques and using a newly created measure of exchange market vulnerability that is unit consistent—such that it combines observed change in exchange rates with the change that is prevented through central bank intervention in a common unit, rather than by combining percentages with dollar-denominated values. This research provides important implications for investors and policymakers.
Fuzzy synthetic evaluation of the systemic obstacles to personalizing knowledge flows within and across projects
Authors: Guribie Francis Lanme , Owusu-Manu De-Graft , Badu Edward , Edwards David John 
Published: April 2022

Purpose
With the recognition that knowledge is ingrained within certain social groups and settings, more recent literature in this field is now spotlighting this human focused or “social dimension” of knowledge management. However, this learning approach faces some constraints, especially, in project context. While the existing body of knowledge has focused on emphasizing the importance of the social processes and practices involved in this approach, there is glaring neglect of the intricacies involved when executing learning through this agency, especially in project settings. Hence, the purpose of this study is to identify and evaluate the systemic obstacles in personalizing knowledge flows within and across projects.

Design/methodology/approach
This study adopted a positivist philosophical stance couched within a deductive approach. A structured questionnaire was used to gather data from 203 construction professionals with “hands-on” experience in managing projects in the Ghanaian construction industry.

Findings
A mean score analysis showed that all the identified obstacles are significant factors that hinder the personalization of knowledge flows within and across projects. A structure detection analysis generated four principal obstacle components (POCs), explaining about 67.897% of the total variance of the obstacles in personalizing knowledge flows in temporary organizations. The complex web of obstacles was broken out into four broad thematic categories or POCs: obstacles at the individual level, obstacles at the team level, obstacles at the structural level and the limitations of project operations. A fuzzy synthetic evaluation modeling of the four POCs generated criticality indices for each POC exceeding 3.50 on a five-point rating scale, indicating that, all the four POCs as significant obstacles to personalizing knowledge flows within and across projects.

Practical implications
Implications are provided for project managers on the social dynamics of learning in project teams.

Originality/value
The research findings expand existing frontiers of knowledge by addressing the gap in the literature on the complexity of the personalization strategy within projects. The findings would also spark a broader discussion about the importance of developing integrated ways to structure learning in project environments. The culmination of the research will serve as a solid foundation for the development of a future project learning frameworks.
Exploring global religious traditions through artifactual literacy projects
Authors: McNeill Erin 
Published: April 2022

PurposeThe purpose of this study is an exploration of stories told by multilingual students participating in a literacy project in a secondary English course as part of a larger three year practitioner inquiry study, in which the author analyzed students’ literacy project to create a culturally responsive English curriculum. In this paper, the stories of two participating students were examined to derive ideas for an English curriculum in which students’ assets, such as cultural heritage and religious traditions, are recognized and honored.Design/methodology/approachTwo objectives of the study were to learn about my students’ assets and to use them to complement the district-mandated texts in ways that honored students’ cultural traditions and accumulated knowledge. This paper focuses on an artifactual literacy project paired with reading the novelTo Kill a Mockingbirdin an English course for emergent bilinguals, in which the modified curriculum highlighted their experiences and traditions.FindingsTwo themes emerged from the analysis. First, religious communities are often valuable to emergent bilingual students. Second, although borders often separate the families of these students, they continue their religious traditions with those in their new communities in the USA, whose members have also carried traditions across borders to honor and preserve their families’ cultures, languages and religions in new places.Originality/valueReligion is rarely discussed in public school English classrooms. This research project demonstrates the value of artifacts in secondary classrooms which provide a space for students to discuss personally meaningful religious and cultural literacy practices.