bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are adolescents’ physical activity and body-related factors associated with medically attended injuries?
Authors: Karchynskaya Viktoryia , Kopcakova Jaroslava , Madarasova Geckova Andrea , Bakalár Peter , de Winter Andrea F. , Reijneveld Sijmen A. 
Published: November 2022

BackgroundInjuries are the major cause of disability and death during adolescence, representing a significant public health burden among youth. Body-related factors such as body composition and cardiovascular fitness (CVF) may affect adolescents’ vulnerability to injuries. As evidence is lacking, we aimed to explore the associations of medically attended injuries with adolescents’ physical activity (PA) and body-related factors, and whether these associations are modified by age, gender and family affluence.MethodsWe used data on 888 11- to 15-year-old adolescents (mean age = 13.5, 56% boys) from the Health Behaviour in School-aged Children study conducted in 2018 in Slovakia. We used binary logistic regression analysis to assess the association of medically attended injuries with adolescents’ PA and body-related factors (body composition, CVF), considering age, gender and family affluence.ResultsAdolescents were more likely to report medically attended injuries if they were physically very active (odds ratio/confidence interval OR/CI:2.76/1.83–4.15) or active (OR/CI:1.91/1.27–2.87) rather than inactive. Body-related factors were not associated with medically attended injuries among adolescents. Moreover, age, gender and family affluence did not modify the association of medically attended injuries with adolescents’ PA and body-related factors. The only exception was the modifying effect of gender: the association of medically attended injuries with being very active was stronger in boys (OR/CI: 3.04/1.32–6.99).ConclusionVery physically active adolescent boys are the most vulnerable group of adolescents in terms of injuries. PA promotion programmes should further consider gender-specific strategies aimed at preventing injuries.
Phase I pharmacokinetic study of an oral, small-molecule MEK inhibitor tunlametinib in patients with advanced NRAS mutant melanoma
Authors: Zhao Qian , Wang Teng , Wang Huanhuan , Cui Cheng , Zhong Wen , Fu Diyi , Xi Wanlin , Si Lu , Guo Jun , Cheng Ying , Tian Hongqi , Hu Pei 
Published: November 2022

Background: Malignant melanoma is an aggressive disease. Tunlametinib (HL-085) is a potent, selective, and orally bioavailable MEK1/2 inhibitor. The objective of this study was to determine the pharmacokinetics (PK) of tunlametinib and its main metabolite M8 in patients with NRAS-mutant melanoma following a single dose and multiple doses in a phase I safety and PK study.Methods: A multiple-center phase I study was performed in patients with melanoma including dose-escalation phase and dose-expansion phase. PK following a single oral dose and multiple doses of 0.5–18 mg twice daily was assessed.Results: A total of 30 participants were included in the dose escalation phase and then 11 patients were included in the dose-expansion phase (12 mg twice daily). Tunlametinib plasma concentration rapidly increased after dosing, with a Tmax of 0.5–1 h. Mean elimination half-life (t1/2) was dose-independent and had a range from 21.84 to 34.41 h. Mean apparent clearance (CL/F) and distribution volume (V/F) were 28.44–51.93 L/h and 1199.36–2009.26 L, respectively. The average accumulation ratios of AUC and Cmax after the multiple administration of tunlametinib were 1.64–2.73 and 0.82–2.49, respectively. Tunlametinib was rapidly transformed into the main metabolite M8 and M8 reached the peak concentration about 1 h after administration. Mean t1/2 of M8 was 6.1–33.54 h. The body exposure of M8 in plasma was 36%–67% of that of tunlametinib. There were general dose-proportional increases in maximum concentration (Cmax) and area under the curve (AUC) of tunlametinib and M8 both in the single dose phase and in the multiple doses phase.Conclusion: Tunlametinib was absorbed rapidly and eliminated at a medium speed after drug withdrawal. Pharmacokinetic body exposure increased in general dose-proportional manner from 0.5 mg up to 18 mg. Slight accumulation was found after multiple oral doses. The pharmacokinetics of tunlametinib and its metabolite suggest that twice daily dosing is appropriate for tunlametinib.
Case report: Indolent drug-related pneumonitis with alectinib therapy in the treatment of non-small cell lung cancer
Authors: Chen Xianmeng , Xia Daqing , Jiang Xuqin , Cao Lejie , Ryu Jay H. , Hu Xiaowen 
Published: November 2022

Molecular targeting therapy is becoming the standard of care for some patients with anaplastic lymphoma kinase (ALK)-rearranged lung adenocarcinoma. Drug-related pneumonitis (DRP) has been identified as an infrequent but potentially severe adverse effect. Herein, we report a 50-year-old woman with ALK-rearranged advanced lung adenocarcinoma who developed interstitial lung disease associated with alectinib therapy. At 102-day of treatment, chest CT revealed scattered ground glass opacities (GGOs) involving both lungs. Since she was asymptomatic and alectinib provided a beneficial tumor treatment response, alectinib therapy was continued. However, 2 months later, she presented with progressive dyspnea and diffuse GGOs on chest computed tomography. There was no evidence for infection or other etiologies for her lung complication. Alectinib was discontinued and steroid therapy was initiated which was followed by improvement in respiratory symptoms and chest CT findings; DRP was diagnosed. Although rare, alectinib therapy can cause DRP of indolent onset.
The association between objective cognitive measures and ecological-functional outcomes in COVID-19
Authors: Ottonello Marcella , Fiabane Elena , Aiello Edoardo Nicolò , Manera Marina Rita , Spada Francesca , Pistarini Caterina 
Published: November 2022

BackgroundCognitive dysfunctions, both subjective and detectable at psychometric testing, may follow SARS-CoV-2 infection. However, the ecological-functional relevance of such objective deficits is currently under-investigated. This study thus aimed at investigating the association between objective cognitive measures and both physical and cognitive, ecological-functional outcomes in post-COVID-19.MethodsForty-two COVID-19-recovered individuals were administered the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The Functional Independence Measure (FIM) was adopted to assess functional-ecological, motor/physical (FIM-Motor) and cognitive (FIM-Cognitive) outcomes at admission (T0) and discharge (T1).ResultsWhen predicting both T0/T1 FIM-total and-Motor scores based on MMSE/MoCA scores, premorbid risk for cognitive decline (RCD) and disease-related features, no model yielded a significant fit. However, the MoCA - but not the MMSE significantly predicted T0/T1 FIM-Cognitive scores. The MoCA was significantly related only to T0/T1 FIM-Cognitive Memory items.DiscussionCognitive measures are not associated with physical/motor everyday-life outcomes in post-COVID-19 patients. The MoCA may provide an ecological estimate of cognitive functioning in this population.
Results from PSIPROSPER: A multicenter retrospective study to analyze the impact of treatment with paliperidone palmitate 1-month on clinical outcomes and hospital resource utilization in adult patients with schizophrenia in Portugal
Authors: Marques-Teixeira João , Amorim Gonçalo , Pires Ana Catarina 
Published: November 2022

BackgroundSchizophrenia is a chronic psychiatric disorder with a significant impact worldwide. The early onset and its relapsing nature pose a significant challenge to patients and caregivers. The PSIPROSPER study aimed to characterize the real-world context of schizophrenia treatment in Portugal and to measure the impact of including paliperidone palmitate 1-month formulation (PP1M) in the clinical outcomes (relapses and hospitalizations) and healthcare resource utilization, in a context in which payment scheme in Portugal allows for patients to receive free antipsychotics if prescribed at public hospitals.MethodsThis was a multicenter, retrospective, observational study. Male and female adults with a diagnosis of schizophrenia who initiated treatment with PP1M after a minimum of 12 months on an Oral Antipsychotic (OAP), and with complete medical charts, were consecutively included. A mirror-image design over 24 months allowed the comparison of outcomes before and after the PP1M introduction.ResultsOut of the 51 patients included, 80.4% were male, with a mean age of 34 (±9.8) years. Around 92% of patients were being treated with PP1M at inclusion. Lack of adherence to previous OAP was the main driver for PP1M initiation. Only 9.8% of patients were hospitalized during the PP1M period vs. 64.7% during the OAP period (p &lt; 0.0001). The mean number of hospitalizations (0.1) was significantly lower during the PP1M period (p &lt; 0.0001). Type of treatment was the only variable found to be significant in predicting a lower hospitalization rate and a lower risk of hospitalization. Relapses were significantly lower (p &lt; 0.0001) in PP1M (21.6%) vs. OAP (83.7%). Similarly, the mean change in the number of relapses (p &lt; 0.0001) showed significantly better outcomes in PP1M.ConclusionThis study supports PP1M as part of schizophrenia treatment in Portugal. Given the lower number of relapses and hospitalizations observed in schizophrenia patients treated with PP1M when compared to OAP-treated patients, this real-world study seems to provide further evidence to support the use of PP1M to treat this condition, in line with previous research. In the context of scarce public resources, these benefits should be carefully considered by healthcare decision-makers to ensure optimal value-based treatment strategies.
Workplace factors can predict the stress levels of healthcare workers during the COVID-19 pandemic: First interim results of a multicenter follow-up study
Authors: Xiong Na-na , Fan Teng-teng , Leonhart Rainer , Fritzsche Kurt , Liu Qi , Luo Lei , Stein Barbara , Waller Christiane , Huang Mingjin , Müller Markus M. ,   The Cope-Corona Working Group
Published: November 2022

BackgroundResearch is lacking on the long-term influence of workplace factors on the mental health of health care workers during the COVID-19 pandemic.MethodsWe distributed two online surveys to health care workers between May and October 2020 (T1) and between February and April 2021 (T2). Perceived stress, coronavirus-related risks, and workplace factors were measured via self-report questionnaires at both time points. We conducted hierarchical linear regression to investigate the predictive factors for high stress.ResultsA total of 2,110 participants from seven countries and 4,240 participants from nine countries were enrolled at T1 and T2, respectively. Among them, 612 participated in both surveys. We called this cohort T1 + T2. High stress was reported in 53.8 and 61.6% of participants at T1 and T2, respectively. In cohort T1 + T2, compared with the baseline, the level of stress rose significantly (6.0 ± 2.9 vs. 6.4 ± 3.1), as did health/safety in the workplace (3.9 ± 0.8 vs. 4.2 ± 0.7). Unfortunately, we did not detect any significant difference concerning support in the workplace. Among all factors at baseline, being older than 35 [β (95% CI) = −0.92 (−1.45, −0.40)], support [−0.80 (−1.29, −0.32)], and health/safety in the workplace [−0.33 (−0.65, −0.01)] were independent protective factors, while a positive history of mental disorders [0.81 (0.26, 1.37)] and rejection in private life [0.86 (0.48, 1.25)] were risk factors for high stress at T2.ConclusionTo relieve the high stress of health care workers, organizational-level approaches should be implemented, especially measures designed to enhance support, health/safety in the workplace, and to reduce the rejection of the public.
Mobile phone-based lifestyle support for families with young children in primary health care (MINISTOP 2.0): Exploring behavioral change determinants for implementation using the COM-B model
Authors: Thomas Kristin , Neher Margit , Alexandrou Christina , Müssener Ulrika , Henriksson Hanna , Löf Marie 
Published: November 2022

BackgroundObesity in childhood is a public health concern worldwide and mobile phone-based interventions (mHealth) has shown to facilitate obesity prevention. However, more research is needed on the implementation of digital tools in routine primary care. This study explored behavior change determinants for implementing a health promotion mHealth intervention (MINISTOP 2.0 app) targeting parents of 4-year-olds.MethodsSecondary data from telephone interviews (n = 15) with child health care nurses working within primary child healthcare in Sweden was analyzed using directed content analysis and the COM-B model.ResultsBarriers for implementation included: limited knowledge about using technology and reservations about how and to what extent parents would use mHealth. Potential facilitators included nurses' openness to learn and try new tools, confidence in their role and engagement in reaching parents as well as beliefs that the app could improve practice by prompting dialogue and being a shared platform. Nurses expressed a strong professional identity and shared understanding of their practice, mechanisms that could potentially inhibit or facilitate implementation.ConclusionsFindings suggest cautious optimism regarding implementing mobile phone-based tools in child primary healthcare in terms of capability, opportunity and motivation among stakeholders. Implementation strategies such as educational outreach visits and making the intervention testable among stakeholders could further facilitate implementation in this clinical context. However, more research is needed on behavior change determinants in different stages of real-world implementation.
Treatment of endometriosis with dienogest in combination with traditional Chinese medicine: A systematic review and meta-analysis
Authors: Wu Yu’e , Liu Yujie , Jia Huanhuan , Luo Chao , Chen Huan 
Published: November 2022

BackgroundEndometriosis is now considered to be a systemic disease rather than a disease that primarily affects the pelvis. Dienogest (DNG) has unique advantages in the treatment of endometriosis, but it also has side effects. Alternatively, Traditional Chinese Medicine (TCM) has been used for over 2000 years in the treatment and prevention of disease and growing numbers of Chinese scholars are experimenting with the combined use of Dienogest and TCM for endometriosis treatment.ObjectivesThis review evaluated the efficacy and safety of TCM in combination with Dienogest in the treatment of endometriosis through meta-analysis.MethodsMEDLINE, Embase, the Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure, Journal Integration Platform, and Wanfang were used in literature searches, with a deadline of May 31, 2022. Literature quality was assessed using the Cochrane Collaboration “risk of bias” (ROB2) tool, and the “meta” package of R software v.4.1 was used for meta-analysis. Dichotomous variables and continuous variables were assessed using the relative risk (RR) and 95% confidence intervals (95% CI); standard mean differences (MD) and 95% CI, respectively.ResultsTwelve human randomized controlled trials (RCTs) and one retrospective study, all 13 written in the Chinese language, were included in the meta-analysis (720 experiments and 719 controls). The result indicated that TCM plus Dienogest was superior to Dienogest/TCM alone in increasing the cure rates (RR = 1.3780; 95% CI, 1.1058, 1.7172; P = 0.0043), remarkable effect rate (RR = 1.3389; 95% CI, 1.1829, 1.5154; P &lt; 0.0001), invalid rate (RR = 0.2299; 95% CI, 0.1591, 0.3322; P &lt; 0.0001), and rate of adverse effects (RR = 0.6177; 95% CI, 0.4288, 0.8899; P = 0.0097). The same conclusion was drawn from the subgroup analysis.ConclusionResults suggest that TCM combined with Dienogest is superior to Dienogest or TCM alone and can be used as a complementary treatment for endometriosis. TCMs have potential to improve clinical efficacy and reduce the side effects of Dienogest. This study was financially supported by Annual Science and Technology Steering Plan Project of Zhuzhou. PROSPERO has registered our meta-analysis as CRD42022339518 (https://www.crd.york.ac.uk/prospero/record_email.php).
Endoscopic lateral neck dissection via the breast and transoral approaches for papillary thyroid carcinoma: A preliminary report
Authors: Kuang Penghao , Wang Yuanyuan , Wu Guoyang , Luo Yezhe , Fu Jinbo , Yan Wei , Lin Suqiong , Hong Xiaoquan , Lin Fusheng , Lin Ende , Fu Yilong 
Published: November 2022

PurposeComplete lymph node dissection is essential for the management of papillary thyroid carcinoma (PTC) with lymph node metastasis (LNM). This work aimed to describe the feasibility of endoscopic lateral neck dissection via the breast and transoral approach (ELNDBTOA) in PTC patients and the necessity of the addition of the transoral approach.MethodsWe included 13 patients with PTC and suspected lateral LNM who underwent ELNDBTOA at the Zhongshan Hospital, Xiamen University. Total thyroidectomy, ipsilateral central lymph node dissection, and selective neck dissection (levels IIA, IIB, III, and IV) were performed endoscopically via the breast approach. Residual lymph nodes were further dissected via the transoral approach.ResultsThe mean operation time was 362.1 ± 73.5 min. In the lateral neck compartments, the mean number of retrieved lymph nodes was 36.6 ± 23.8, and the mean number of positive lymph nodes was 6.8 ± 4.7. In further dissection via the transoral approach, lymph nodes in the lateral neck compartment were obtained in nine patients (9/13, 69.2%), and three patients (3/13, 23.1%) had confirmed lateral neck metastases. Transient hypocalcemia occurred in two patients (2/13, 15.4%), and three patients (3/13, 23.1%) developed transient skin numbness in the mandibular area. No other major complications were observed. There was no evidence of local recurrence or distant metastasis during the follow-up period (range, 24–87 months). All patients were satisfied with the good cosmetic outcome.ConclusionELNDBTOA is an option with proven feasibility for select PTC patients with LNM, and the addition of the transoral approach is necessary to ensure complete dissection.
Intratumoral injection of holmium-166 microspheres as neoadjuvant therapy of soft tissue sarcomas in dogs
Authors: Morsink Nino Chiron , Nijsen Johannes Frank Wilhelmus , Grinwis Guillaume Cornelis Maria , Hesselink Jan Willem , Kirpensteijn Jolle , van Nimwegen Sebastiaan Alexander 
Published: November 2022

IntroductionMinimally invasive microbrachytherapy is in development to treat solid tumors by intratumoral injection of (radioactive) holmium-166 (166Ho) microspheres (MS). A high local dose can be administered with minimal damage to surrounding tissue because of the short soft tissue penetration depth of 166Ho beta radiation. We aimed to prospectively evaluate the safety and efficacy of 166Ho microbrachytherapy in client-owned canine patients with soft tissue sarcomas (STS).MethodsWe included seven dogs with STS not suitable for local excision due to tumor size and/or location. 166HoMS were suspended in a carrier fluid and multiple needle-injections were performed in predetermined tumor segments to maximize tumor coverage. Tumor response was evaluated using 3D caliper and CT measurements. Follow-up further included monitoring for potential side effects and registration of subsequent treatments and survival, until at least two years after treatment.ResultsDelivered radioactive doses ranged from 70 to 969 Gy resulting in a mean tumor volume reduction of 49.0 ± 21.3% after 33 ± 25 days. Treatment-related side effects consisted of local necrosis (n = 1) and ulceration of the skin covering the tumor (n = 1), which resolved with basic wound care, and surgical excision of residual tumor, respectively. Residual tumor was surgically resected in six patients after 22–93 days. After a mean follow-up of 1,005 days, four patients were alive, two patients were euthanized because of unrelated causes, and one patient was euthanized because of disease progression after the owner(s) declined subsequent surgical treatment.Conclusion166Ho microbrachytherapy was a safe and effective neoadjuvant treatment option for canine patients with STS.
El Proceso de Aceptación y Adaptación a la Bisexualidad a través de la Terapia Cognitivo-Conductual con Enfoque Afirmativo
Authors: Rodríguez Riesco Lorenzo , Vivas Sebastián , Ruiz-Duet Ana M. , Pérez-Calvo Cristina 
Published: November 2022

Las personas del colectivo LGBTIQ+ vivencian en su día a día diversas situaciones de estigmatización social, repercutiendo en su bienestar emocional y su salud mental. Estas actitudes negativas pueden moderar los sentimientos y percepciones de aquellas que pasan a formar parte del colectivo, como ocurre con la bisexualidad. En este estudio se presenta un acercamiento cognitivo-conductual con enfoque afirmativo en un caso de adaptación y aceptación de una usuaria que recientemente “redescubre” su orientación bisexual. A lo largo de 12 sesiones, a través de la psicoeducación, la restructuración cognitiva, el entrenamiento en asertividad y la exposición; se consigue reducir en la usuaria las diferentes problemáticas detectadas. Se consigue reducir los sentimientos de tristeza y ansiedad, se reduce el estrés percibido en situaciones problemáticas y se optimizan sus recursos en gestión emocional, obteniendo mejores resultados cuantitativos en la Escala de Evaluación de Resultados. Se concluye que este tipo de abordajes psicoterapéuticos son efectivos.
Rosa y el canto inaudible: no- lugar, lugares de memoria y nexo voz-lugar
Authors: Mena Rosario 
Published: November 2022

En base la experiencia de la cantora y educadora intercultural aymara Rosa Qhispi (Región de Tarapacá, norte de Chile) se aborda el vínculo entre canto y lugar en tres vertientes cruzadas. La relativa al rol (lugar) tradicional de la cantora andina explicita su carencia de un lugar de enunciación, configurada por un silenciamiento histórico y estructural –perpetuado en la interculturalidad neoliberal– que determina su inaudibilidad. La geográfica, por su parte, refiere a la migración a la ciudad, el desarraigo y la situación de translocalidad que caracteriza a las y los sujetos aymaras en la región, en permanente tránsito entre los espacios urbanos y rurales. Por último, en la dimensión mnémica se propone a las prácticas musicales como lugares de memoria en cuanto instancias de recreación de la memoria colectiva que se activan en diferentes espacios y contextos, con distintos niveles de vinculación territorial. El disco, como lugar de memoria deslocalizado, constituye una herramienta fundamental al permitir a Rosa performar y proyectar su rol de acuerdo con sus propias nociones de tradición e interculturalidad. Los animales presentes en las canciones potencian el nexo voz-lugar del canto con la comunidad y la naturaleza.