bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naltrexone for alcohol use disorder: Hepatic safety in patients with and without liver disease
Authors: Ayyala Divya , Bottyan Thomas , Tien Christine , Pimienta Michael , Yoo Jennie , Stager Kelli , Gonzalez Jose Luis , Stolz Andrew , Dodge Jennifer L. , Terrault Norah A. , Han Hyosun 
Published: October 2022

Abstract
Naltrexone is an approved drug for management of alcohol use disorder (AUD), but data in patients with liver disease (LD) are limited. We aimed to evaluate the safety of naltrexone in those with LD. This is a retrospective cohort of adults with and without LD who were prescribed naltrexone for AUD from 2015 to 2019 in a safety‐net setting. Naltrexone hepatic safety was determined by liver enzyme changes during and after compared to before naltrexone prescription as well as rates of subsequent hospitalization and death by Kaplan‐Meier methods. Factors associated with hospitalization were examined by Cox regression. Of 160 patients prescribed naltrexone for AUD, 100 (63%) had LD and 47 (47%) of those with LD had cirrhosis (47% decompensated). The total cohort, LD, and cirrhosis groups had lower adjusted mean aspartate aminotransferase and alanine aminotransferase levels after versus before naltrexone prescription (p < 0.001). Two‐year survival was 97.7% (95% confidence interval [CI], 84.6–99.7), 95.4% (95% CI, 82.8–98.8), 90.8% (95% CI, 73.5–97.0), and 81.3% (95% CI, 41.2–93.8) in those without LD, LD without cirrhosis, cirrhosis, and decompensated cirrhosis groups (p = 0.46), respectively. Alcohol‐related 2‐year hospitalization rates were 8.2% (95% CI, 2.7–24), 27.7% (95% CI, 16.6–44.0), 40.5% (95% CI, 24.8–61.6), and 41.7% (95% CI, 23.3–66.6) for the groups without LD, LD without cirrhosis, cirrhosis, and decompensated cirrhosis (p = 0.007), respectively. Independent predictors of subsequent hospitalization were LD, (hazard ratio [HR], 3.70; 95% CI, 1.19–11.51; p = 0.02), cirrhosis (HR, 5.16; 95% CI, 1.69–15.75), and shorter duration (≤30 days) of naltrexone prescription (HR, 2.50; 95% CI, 1.l2–5.20; p = 0.01). Conclusion: Naltrexone is safe to use in patients with underlying LD, including those with compensated cirrhosis. Although encouraging, more safety data are needed for those with decompensated cirrhosis.
Pnictogen‐Bonding Catalysts, Compared to Tetrel‐Bonding Catalysts: More Than Just Weak Lewis Acids
Authors: Chen Hao , Frontera Antonio , Ángeles Gutiérrez López M. , Sakai Naomi , Matile Stefan 
Published: October 2022

AbstractA hyperresponsive tool to assess supramolecular catalysis, the cyclization of di‐epoxides into cyclic ethers is used to elucidate the difference between pnictogen‐bonding and Lewis acid catalysis systematically. For all stereoisomers, most tested catalysts follow the Baldwin rules. Brønsted acid and anion–π catalysis afford almost only Baldwin products. Lewis acids such as SbCl3, BF3 and BiCl3 give the poorest selectivity, with at least 50 % Baldwin (B) products for all stereoisomers. In clear contrast, optimized pnictogen‐bonding catalysts operating on the Sb(III) and the Sb(V) level give the fused anti‐Baldwin (A) bicycles as the main product of trans epoxides, independent of syn or anti relation of the two epoxides. In the cis series, Sb(III) pnictogen‐bonding catalysts afford BA products almost exclusively for syn diastereomers, while anti diastereomers give equal amounts of BA and AB products. Sb(V) pnictogen‐bonding catalysts show similarly special trends. These unique characteristics support that pnictogen‐bonding catalysis differs from Lewis acid catalysis and can arguably be defined as its non‐covalent counterpart, just like hydrogen‐bonding catalysis is understood and appreciated as the non‐covalent counterpart of Brønsted acid catalysis. Computational studies on the origin of anti‐Baldwin selectivity reveal Sb(V) catalysts with an introvert deep σ hole surrounded by an almost planar ring of ligands. Central pnictogen‐bond attraction against peripheral steric repulsion then forces the epoxide to break open. In contrast, transient antimony oxidation in cyclic intermediates accounts for the chemoselectivity of Sb(III) catalysts. Presumably due to insufficient accessibility of their σ holes, the activity of tetrel‐bonding catalysts is negligible. The division between powerful pnictogen‐bonding and irrelevant tetrel‐bonding catalysts does not exist with the respective orthodox Lewis acids and thus supports that σ‐hole and Lewis acid catalysis are not the same.
MicroRNA‐9a‐5p‐NOX4 inhibits intestinal inflammatory injury by regulating the M1 polarization of intestinal macrophages
Authors: Li Wenyan , Sheng Yongjia , Wang Jin , Wu Shasha , Han Chenyang 
Published: October 2022

AbstractWe found that the expression of microRNA (miRNA)‐9a‐5p decreased in inflammatory bowel diseases (IBD; ulcerative colitis and Crohn's disease). Further, we revealed the effects and mechanisms of miRNA‐9a‐5p for regulating IBD progression. In C57BL/6N mice, IBD was induced with dextran sodium sulfate (DSS), and the effects of endogenous miRNA‐9a‐5p were mimicked/antagonized through intraperitoneal injection of miRNA‐9a‐5p agomir and antagomir. In animal experimentation, agomir could inhibit intestinal inflammation and tissue damage, and reduce the mucosal barrier permeability. Antagomir, on the other hand, could promote barrier damage, whose effect was associated with the M1 macrophage polarization. This study finds that miRNA‐9a‐5p targets NOX4 to suppress ROS production, which plays an important role in mucosal barrier damage in IBD.
Genetic testing and counseling for the unexplained epilepsies: An evidence‐based practice guideline of the National Society of Genetic Counselors
Authors: Smith Lacey , Malinowski Jennifer , Ceulemans Sophia , Peck Katlin , Walton Nephi , Sheidley Beth Rosen , Lippa Natalie 
Published: October 2022

AbstractEpilepsy, defined by the occurrence of two or more unprovoked seizures or one unprovoked seizure with a propensity for others, affects 0.64% of the population and can lead to significant morbidity and mortality. A majority of unexplained epilepsy (seizures not attributed to an acquired etiology, such as trauma or infection) is estimated to have an underlying genetic etiology. Despite rapid progress in understanding of the genetic underpinnings of the epilepsies, there are no recent evidence‐based guidelines for genetic testing and counseling for this population. This practice guideline provides evidence‐based recommendations for approaching genetic testing in the epilepsies using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision framework. We used evidence from a recent systematic evidence review and meta‐analysis of diagnostic yield of genetic tests in patients with epilepsy. We also compiled data from other sources, including recently submitted conference abstracts and peer‐reviewed journal articles. We identified and prioritized outcomes of genetic testing as critical, important or not important and based our recommendations on outcomes deemed critical and important. We considered the desirable and undesirable effects, value and acceptability to relevant stakeholders, impact on health equity, cost‐effectiveness, certainty of evidence, and feasibility of the interventions in individuals with epilepsy. Taken together, we generated two clinical recommendations: (1) Genetic testing is strongly recommended for all individuals with unexplained epilepsy, without limitation of age, with exome/genome sequencing and/or a multi‐gene panel (>25 genes) as first‐tier testing followed by chromosomal microarray, with exome/genome sequencing conditionally recommended over multi‐gene panel. (2) It is strongly recommended that genetic tests be selected, ordered, and interpreted by a qualified healthcare provider in the setting of appropriate pre‐test and post‐test genetic counseling. Incorporation of genetic counselors into neurology practices and/or referral to genetics specialists are both useful models for supporting providers without genetics expertise to implement these recommendations.
Chloride Ion‐Containing Polymeric Ionic Liquids for Application as Electrolytes in Solid‐State Batteries
Authors: Ehrlich Lisa , Pospiech Doris , Muza Upenyu L. , Lederer Albena , Muche Julia , Fischer Dieter , Uhlmann Petra , Tzschöckell Felix , Muench Simon , Hager Martin D. , Schubert Ulrich S. 
Published: October 2022

AbstractOrganic, solid‐state batteries require efficient solid electrolytes able to provide stable ion conduction. Here, solid electrolytes based on ionic liquid (IL) polymers with chloride counterions as electrolyte materials for batteries are presented. Acrylic monomers with imidazolium substituents with alkyl side groups that are linked by alkyl spacers to the acrylic group are employed. The IL monomers with chloride counterions are either converted by thermally initiated radical polymerization into linear homopolymers or incorporated into polymer networks by UV‐initiated copolymerization utilizing a bifunctional, non‐ionic cross‐linker. Both procedures successfully yielded the desired materials, which is confirmed by NMR spectroscopy (linear homopolymers) or Raman spectroscopy (IL networks). The ionic conductivities at room temperature are measured by Electrochemical Impedance Spectroscopy. The ionic conductivities of the linear homopolymers are in the range of 10−4 to 10−6 S cm−1, while those of the IL networks are about two orders of magnitude lower. They increase to 10−4 S cm−1 at 70 °C. The electrochemical stability is examined by Linear Sweep Voltammetry and is proven in the voltage range of −2 to +2 V. The results reveal that the materials represent promising electrolytes for potential solid‐state battery applications.
A Review on Wearable Electrospun Polymeric Piezoelectric Sensors and Energy Harvesters
Authors: Mirjalali Sheyda , Mahdavi Varposhti Arezo , Abrishami Shayan , Bagherzadeh Roohollah , Asadnia Mohsen , Huang Shujuan , Peng Shuhua , Wang Chun‐Hui , Wu Shuying 
Published: October 2022

AbstractIn recent years, wearable sensors and energy harvesters have shown great potential for a wide range of applications in personalized healthcare, robotics, and human–machine interfaces. Among different types of materials used in wearable electronics, piezoelectric materials have gained enormous attention due to their exclusive ability to harvest energy from ambient sources. Piezoelectric materials can be utilized as sensing elements in wearable sensors while harvesting biomechanical energy. Electrospun piezoelectric polymer nanofibers are extensively investigated due to their high flexibility, ease of processing, biocompatibility, and higher piezoelectric property (in contrast to their corresponding cast films). However, as compared to piezoceramic materials, they mostly exhibit relatively lower piezoelectric coefficients. Therefore, considerable efforts have been devoted to improving the piezoelectricity of electrospun polymer nanofibers recently, resulting in significant advances. This review presents a broad overview of these advances including new material, structure designs as well as new strategies to enhance piezoelectricity of electrospun polymer nanofibers. The challenges in achieving high mechanical performance as well as high piezoelectricity are particularly discussed. The main motivation of this review is to examine these challenges and highlight effective approaches to achieving high‐performance piezoelectric sensors and energy harvesters for wearable technologies.
Emerging Synthetic Methods and Applications of MOF‐Based Gels in Supercapacitors, Water Treatment, Catalysis, Adsorption, and Energy Storage
Authors: Hou Xueting , Sun Jiaxin , Lian Mengying , Peng Yang , Jiang Dawei , Xu Miaojun , Li Bin , Xu Qiang 
Published: October 2022

AbstractMetal–organic frameworks (MOFs), which are synthesized through the self‐assembly of organic ligands and inorganic metals, have drawn considerable research interest owing to their unique properties and attractive structures. Many studies on various MOF derivatives, such as MOFs and cellulose aerogels, hydrogel composite materials, and bimetallic‐centered MOF materials, have provided the potential for wide application of MOFs. However, MOFs mostly exist in the form of powder particles, which are difficult to form. In addition, MOFs have problems with structural instability. MOF‐based gels can overcome this problem. MOF‐based gels also have significant advantages in secondary processing. In this review, synthetic methods for MOF‐based gels, particularly the synergistic effect with other materials, are introduced. The applications of MOF‐based hydrogels and aerogels in supercapacitors, water treatment, catalysis, adsorption, and energy storage are also discussed.
Highly Aligned Centrifugal Spun Polyacrylonitrile Nanofibers Collected and Processed with Automated Tracks
Authors: Jao Dave , Lima Thamires Andrade , Thursch Lavenia , Flamini Matthew D. , Pressly James , Ippolito Jason , Alvarez Nicolas Javier , Beachley Vince 
Published: October 2022

AbstractA parallel automated track collector is integrated with a rationally designed centrifugal spinning head to collect aligned polyacrylonitrile (PAN) nanofibers. Centrifugal spinning is an extremely promising nanofiber fabrication technology due to high production rates. However, continuous oriented fiber collection and processing presents challenges. Engineering solutions to these two challenges are explored in this study. A 3D‐printed head design, optimized through a computational fluid dynamics simulation approach, is utilized to limit unwanted air currents that disturb deposited nanofibers. An automated track collecting device has pulled deposited nanofibers away from the collecting area. This results in a continuous supply of individual aligned nanofibers as opposed to the densely packed nanofiber mesh ring that is deposited on conventional static post collectors. The automated track collector allows for simple integration of the postdraw processing step that is critical to polymer fiber manufacturing for enhancing macromolecular orientation and mechanical properties. Postdrawing has enhanced the mechanical properties of centrifugal spun PAN nanofibers, which have different crystalline properties compared with conventional PAN microfiber. These technological developments address key limitations of centrifugal spinning that can facilitate high production rate commercial fabrication of highly aligned, high‐performance polymer nanofibers.
On Betti numbers of the gluing of germs of formal complex spaces
Authors: Freitas Thiago H. , Pérez Victor H. Jorge , Miranda Aldício J. 
Published: October 2022

AbstractIn this paper, we show that the gluing of germs of formal complex spaces is also a formal complex space. Moreover, we study the Betti numbers of the gluing of formal complex spaces and, for instance, we show that the Betti numbers satisfy
for all , where is a d‐dimensional germ of formal complex space given by a regular and a singular germ of formal complex spaces with the same dimension. In particular, this proves the Buchsbaum–Eisenbud–Horrocks conjecture for certain gluing of germs of formal complex spaces. Some formulas for the Betti numbers of the gluing of germs of formal complex spaces are given in terms of the invariant multiplicities, Euler obstruction, Milnor number, and polar multiplicities. As an application, some upper bounds for the Betti numbers of the gluing of some germs of complete intersection are provided, using recent progress on the Watanabe's conjecture.
Molecular Dynamics Simulation for Separation Performance of PDMS/Fluorosilane Membrane with Different Mass Ratios in Acetone–Water Mixture
Authors: Lan Yunrui , Song Weijin , Wang Jincheng 
Published: October 2022

AbstractPolydimethylsiloxane (PDMS) membrane in suitable‐fluorinated level have excellent pervaporation performance as well as antibiological contamination performance. The pervaporation membranes with different PDMS/fluorosilane mass ratios, the adsorption and dissolution behaviors of acetone molecules on the membrane surface, as well as the diffusion and permeation behaviors in the membranes are studied by all‐atom molecular dynamics simulation (AAMDS). The results show that when the mass ratio of PDMS/fluorosilane is 100/20, the surface solubility of acetone is 11.711 (J cm−3)0.5, and the interfacial interaction is −16897.0415 kcal mol−1, both of which are the highest. The results of wide‐angle X‐ray diffraction (WAXD) showed that there are amorphous regions in the membranes suitable for acetone penetration. The maximum chain spacing of the PDMS/fluorosilane(100/20)_membranes is 10.8482 Å, and the free volume fraction (FFV) is 3.03%, both of which are the largest. The change rate of long‐term mean square displacement (MSD) in PDMS/fluorosilane(100/20)_Membrane with time is 0.45269. The Young's modulus E, shear modulus G, volume modulus K, and Poisson's ratio ν of PDMS/fluorosilane(100/20)_Membrane are 0.3249, 0.4061, 0.0492 GPa and ‐0.5999, respectively. The elasticity of the membrane enhances the diffusion behavior of acetone molecules, and the self‐diffusion coefficient of acetone in the membrane is 0.07545 Å2 ps−1.
Smart intraoral systems for advanced drug delivery
Authors: Liu Yuan , Guo Honglian , Xu Rengui , Chen Wei 
Published: October 2022

AbstractDrug administration through the oral cavity is considered to be a convenient, effective, and time‐saving strategy in the clinic with high safety and quick onset, especially for patients with needle fear and swallowing difficulties. Without the degradation in gastrointestinal tract and first‐pass metabolism, the intraoral drug delivery system turns out to be an attractive option for macromolecule absorption, which will provide a promising platform for the successful delivery of protein, peptide, nucleic acid, and polysaccharide. Nevertheless, limited bioavailability, short retention time, and poor reproducibility pose a major hurdle to the further application of conventional intraoral drug delivery systems. Recent advances in chemical, material, and engineering techniques bring great opportunities to improve intraoral system fabrication and applications, owing to the high biocompatibility and functional diversity. In this review, we systematically summarize the recent development of smart intraoral drug delivery systems, including fast dissolving oral films, medicinal chewing gum systems, intraoral mucoadhesive systems, physical assisted systems, intelligent intraoral device, and chemically assisted systems. Moreover, the challenges and prospects for clinical and industrial applications of current strategies are well discussed. It is believed that the smart intraoral system would serve as a promising candidate to improve human life in the near future.
Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5
Authors: Che Yingying , Bai Mixue , Lu Kun , Fu Lin 
Published: October 2022

AbstractAberrant alternative splicing (AS) profoundly affects tumorigenesis and cancer progression. Serine/arginine‐rich splicing factor 3 (SRSF3) regulates the AS of precursor mRNAs and acts as a proto‐oncogene in many tumors, but its function and potential mechanisms in cervical cancer remain unclear. Here, we found that SRSF3 was highly expressed in cervical cancer tissues and that SRSF3 expression was correlated with prognosis after analyses of the The Cancer Genome Atlas and GEO databases. Furthermore, knockdown of SRSF3 reduced the proliferation, migration, and invasion abilities of HeLa cells, while overexpression of SRSF3 promoted proliferation, migration, and invasion of CaSki cells. Further studies showed that SRSF3 mediated the variable splicing of exon 12 of the transcriptional cofactor DEAD‐box helicase 5 (DDX5). Specifically, overexpression of SRSF3 promoted the production of the pro‐oncogenic spliceosome DDX5‐L and repressed the production of the repressive spliceosome DDX5‐S. Ultimately, both SRSF3 and DDX5‐L were able to upregulate oncogenic AKT expression, while DDX5‐S downregulated AKT expression. In conclusion, we found that SRSF3 increased the production of DDX5‐L and decreased the production of DDX5‐S by regulating the variable splicing of DDX5. This, in turn promoted the proliferation, migration, and invasion of cervical cancer by upregulating the expression level of AKT. These results reveal the oncogenic role of SRSF3 in cervical cancer and emphasize the importance of the SRSF3‐DDX5‐AKT axis in tumorigenesis. SRSF3 and DDX5 are new potential biomarkers and therapeutic targets for cervical cancer.
Chitooligosaccharides Attenuated Hepatic Encephalopathy in Mice through Stabilizing Gut–Liver–Brain Disturbance
Authors: Liu Peng , Li Heng , Xu Hongyu , Gong Jinsong , Jiang Min , Qian Jianying , Xu Zhenghong , Shi Jinsong 
Published: October 2022

ScopeHepatic encephalopathy (HE) refers to neurological dysfunction associated with hepatic inadequacy and gut dysbiosis. Chitooligosaccharides (COS) possesses prominent biological activities including incalculable hepatoprotective, neuroprotective and prebiotic effects. This study evaluates the protective effects of COS on HE from the influence of gut–liver–brain axis in mice.Methods and resultsHepatic injured mice show minimal symptoms of HE, reflecting in cognitive impairment, and learning and memory retardation, while they are reversed by COS following orally administrated. Furthermore, COS ameliorates brain function through inhibiting microglial and astrocyte activation in cerebral cortex and hippocampus, promoting neuronal regeneration characterized by the increase of neuron‐specific marker (neuronal nuclear antigen, NeuN). Concurrently, neuroinflammation and hepatitis are restrained by COS through descending toll‐like receptors 4/Nuclear factor kappa B (TLR4/NF‐κB) pathway. Additionally, the dysbiosis of the composition and structure of gut microbiota is displayed in mice with HE, while it is modified by COS through decreasing the relative abundances of Muribaculaceae, Lactobacillus, and Enterorhabdus. The enhancement of blood ammonia is crucially slipped to basal levels by COS.ConclusionThe present study shows that COS could prevent the pathological process of HE through regulating the gut–liver–brain cross‐talk, which provids new insight into fundamental roles of COS.
A superstrate and FSS embedded dual band waveguide aperture array with improved far‐field characteristics
Authors: Chandra Avinash , Mishra Naveen , Kumar Rajkishor , Kumar Kundan , Patil Hemprasad Yashwant 
Published: October 2022

AbstractIn this article, frequency selective surfaces (FSS) and superstrate embedded waveguide aperture arrays have been proposed. Three FSS are embedded in the transverse‐plane in WR‐90 waveguide and the unit superstrate cell is kept at a certain distance to achieve circular polarization. Optimization and analysis have been done by commercially available software Ansys HFSS 16.0. The proposed array has dual‐band behavior with input reflection coefficient ranges from 8.5 to 9.53 GHz and 10.15 to 10.49 GHz. Further analysis shows that the presented array has a higher gain as compared with the conventional open‐ended WR‐90 waveguide. In addition, the proposed array also provides low cross‐polarization and 5–6 dBi higher gain compared with the open WR‐90 waveguide array.