bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs
Authors: Boonyarattanasoonthorn Tussapon , Kongratanapasert Teetat , Maiuthed Arnatchai , Hamlin Robert , Kijtawornrat Anusak , Khemawoot Phisit 
Published: December 2022

AbstractCentell-S is a water-soluble extract ofCentella asiaticacontaining more than 80% w/w triterpenoid glycosides. Madecassoside and asiaticoside are two major components of the extract and can be converted into active metabolites, triterpenic acids in large mammal species. In this study, the pharmacokinetic profiles and metabolomic changes generated by the bioactive triterpenoids of Centell-S alone, and in combination with the bioenhancers piperine and curcumin, were investigated in beagle dogs. The test substances were orally administered over multiple doses for 7 consecutive days. At day 1 and 7 after receiving the test compounds, the level of major bioactive triterpenoids and related metabolites were measured using triple quadrupole and high-resolution accurate mass orbitrap models of LCMS to determine pharmacokinetic and metabolomic profiles, respectively. Centell-S was well tolerated, alone and in all combination groups. The combination of Centell-S and piperine significantly increased (p < 0.05) the systemic exposure of madecassoside on day 1 and asiatic acid on day 7, by approximately 1.5 to 3.0-fold of Cmaxand AUC values as compared to the Centell-S alone, while the addition of curcumin did not provide a significant improvement. Several metabolomic changes were observed from pre-dose to 4 h post-dose, with some biomarkers of neurodegenerative diseases includingl-glutamine, lysophosphatidylcholine (17:0), taurochenodeoxycholic acid, uric acid, stearic acid, palmitic acid, and lactic acid showing good correlation with the systemic exposure of the bioactive triterpenoids (asiatic acid). Thus, the combining of piperine to Centell-S exhibits the improvement of bioactive triterpenoids which are related to the biomarkers of neurodegenerative diseases. These promising results might be useful for the development of this standardised extract to become a more effective phytomedicine for neurodegenerative diseases.
Accelerated 23-h enhanced recovery protocol for colon surgery: the CHASE-study
Authors: Tweed Thaís T. T. , Sier Misha A. T. , Daher Imane , Bakens Maikel J. A. M. , Nel Johan , Bouvy Nicole D. , van Bastelaar James , Stoot Jan H. M. B. 
Published: December 2022

AbstractThe introduction of the Enhanced Recovery After Surgery (ERAS) program has radically improved postoperative outcomes in colorectal surgery. Optimization of ERAS program to an accelerated recovery program may further improve these said outcomes. This single-center, prospective study investigated the feasibility and safety of a 23-h accelerated enhanced recovery protocol (ERP) for colorectal cancer patients (ASA I–II) undergoing elective laparoscopic surgery. The 23-h accelerated ERP consisted of adjustments in pre-, peri- and postoperative care; this was called the CHASE-protocol. This group was compared to a retrospective cohort of colorectal cancer patients who received standard ERAS care. Patients were discharged within 23 h after surgery if they met the discharge criteria. Primary outcome was the rate of the successful discharge within 23 h. Successful discharge within the CHASE-cohort was realized in 33 out of the 41 included patients (80.5%). Compared to the retrospective cohort (n = 75), length of stay was significantly shorter in the CHASE-cohort (p = 0.000), and the readmission rate was higher (p = 0.051). Complication rate was similar, severe complications were observed less frequently in the CHASE-cohort (4.9% vs. 8.0%). Findings from this study support the feasibility and safety of the accelerated 23-h accelerated ERP with the CHASE-protocol in selected patients.
Mean corpuscular haemoglobin concentration (MCHC): a new biomarker for high-altitude pulmonary edema in the Ecuadorian Andes
Authors: Sánchez Karen , Ramírez-Cando Lenin , Machado Wilfre , Villafuerte Anita , Ballaz Santiago 
Published: December 2022

AbstractAscent to high altitude (> 3000 m height above sea level or m.a.s.l) exposes people to hypobaric atmospheric pressure and hypoxemia, which provokes mountain sickness and whose symptoms vary from the mild acute mountain sickness to the life-threatening, high-altitude pulmonary edema (HAPE). This study analysed the risk factors underlying HAPE in dwellers and travellers of the Ecuadorian Andes after sojourning over 3000 m height. A group of HAPE patients (N = 58) was compared to a NO HAPE group (N = 713), through demographic (ethnicity, sex, and age), red blood cell parameters (erythrocytes counts, hematocrit, median corpuscular volume, median corpuscular haemoglobin, and median corpuscular haemoglobin concentration (MCHC)), altitude (threshold: 3000 m.a.s.l.), and health status (vital signs) variables. Analysis of Deviance for Generalised Linear Model Fits (logit regression) revealed patterns of significant associations. High-altitude dwellers, particularly children and elder people, were HAPE-prone, while women were more tolerant of HAPE than men. Interestingly, HAPE prevalence was strongly related to an increment of MCH. The residence at middle altitude was inversely related to the odds of suffering HAPE. Ethnicity did not have a significant influence in HAPE susceptibility. Elevated MCHC emerges like a blood adaptation of Andean highlanders to high altitude and biomarker of HAPE risk.
Free convective trickling over a porous medium of fractional nanofluid with MHD and heat source/sink
Authors: Lin Yuanjian , Rehman Sadique , Akkurt Nevzat , Shedd Tim , Kamran Muhammad , Qureshi Muhammad Imran , Botmart Thongchai , Alharbi Abdulaziz N. , Farooq Aamir , Khan Ilyas 
Published: December 2022

AbstractNanofluids are considered as smart fluids that can improve heat and mass transfer and have numerous applications in industry and engineering fields such as electronics, manufacturing, and biomedicine. For this reason, blood-based nanofluids with carbon nanotubes (CNTs) as nanoparticles in the presence of a magnetic field are discussed. The nanofluid traverses the porous medium. The nanofluids move on a vertical plate that can be moved. The free convection heat transfer mode is considered when the heat source and heat fluxes are constant. Convective flows are often used in engineering processes, especially in heat removal, such as geothermal and petroleum extraction, building construction, and so on. Heat transfer is used in chemical processing, power generation, automobile manufacturing, air conditioning, refrigeration, and computer technology, among others. Heat transfer fluids such as water, methanol, air and glycerine are used as heat exchange media because these fluids have low thermal conductivity compared to other metals. We have studied the effects of MHD on the heat and velocity of nanofluids keeping efficiency in mind. Laplace transform is used to solve the mathematical model. The velocity and temperature profiles of MHD flow with free convection of nanofluids were described using Nusselt number and skin friction coefficient. An accurate solution is obtained for both the velocity and temperature profiles. The graph shows the effects of the different parameters on the velocity and temperature profiles. The temperature profile improved with increasing estimates of the fraction parameter and the volume friction parameter. The velocity of the nanofluid is also a de-escalating function with the increasing values of the magnetic parameter and the porosity parameter. The thickness of the thermal boundary layer decreases with increasing values of the fractional parameter.
Evaluation of the mineral composition, phytochemical and proximate constituents of three culinary spices in Nigeria: a comparative study
Authors: Evuen Uduenevwo Francis , Okolie Ngozi Paulinus , Apiamu Augustine 
Published: December 2022

AbstractSpices are prolific sources of phytochemicals of pharmaceutical and nutritional importance. They have been employed for centuries in the treatment of various maladies, in cuisines, and as inhibitors of oxidative degradation in foods. On this premise, a comparative assessment of the quantitative mineral composition, phytochemical and proximate constituents ofXylopia aethiopica(fruits), Piper guineense(seeds), andRhaphiostylis beninensis(roots) was done using standard protocols. Subsequently, methanol extracts of the spices were subjected to Gas Chromatography–Mass Spectrometry (GC–MS) analysis. Mineral analysis of the culinary spices revealed significant differences (p < 0.05) in the spices’ magnesium, zinc, iron, selenium, copper, calcium, manganese, molybdenum, potassium, and sodium contents. In the phytochemical analysis, flavonoids, phenols, and alkaloids (4.04%, 2.92%, 2.23%) predominate inX. aethiopica. Similarly, proximate analysis shows a preponderance of carbohydrates (81.24%) and proteins (4.83%) inR. beninensisandP. guineenserespectively. However, values for the selenium (0.25 mg/L), saponin (0.23%), and moisture (0.71%) contents forR. beninensiswere the lowest among the three spices. Results from the GC–MS analysis revealed the presence of thirteen, twelve, and thirteen phytoconstituents ofX. aethiopica, P. guineense, andR. beninensisrespectively. Prominent among them are hydrocarbons, acids, and esters with renowned biological attributes such as antioxidant, antimicrobial and anti-inflammatory. These findings indicate that the spices are notable wellsprings of bioactive components and justify their plethoric applications in Nigeria. Therefore, they could serve as lead compounds in the search for natural ingredients for drugs and nutraceuticals formulation.
Future tree survival in European forests depends on understorey tree diversity
Authors: Billing Maik , Thonicke Kirsten , Sakschewski Boris , von Bloh Werner , Walz Ariane 
Published: December 2022

AbstractClimate change heavily threatens forest ecosystems worldwide and there is urgent need to understand what controls tree survival and forests stability. There is evidence that biodiversity can enhance ecosystem stability (Loreau and de Mazancourt in Ecol Lett 16:106–115, 2013; McCann in Nature 405:228–233, 2000), however it remains largely unclear whether this also holds for climate change and what aspects of biodiversity might be most important. Here we apply machine learning to outputs of a flexible-trait Dynamic Global Vegetation Model to unravel the effects of enhanced functional tree trait diversity and its sub-components on climate-change resistance of temperate forests (http://www.pik-potsdam.de/~billing/video/Forest_Resistance_LPJmLFIT.mp4). We find that functional tree trait diversity enhances forest resistance. We explain this with 1. stronger complementarity effects (~ 25% importance) especially improving the survival of trees in the understorey of up to + 16.8% (± 1.6%) and 2. environmental and competitive filtering of trees better adapted to future climate (40–87% importance). We conclude that forests containing functionally diverse trees better resist and adapt to future conditions. In this context, we especially highlight the role of functionally diverse understorey trees as they provide the fundament for better survival of young trees and filtering of resistant tree individuals in the future.
Energy transition minerals and their intersection with land-connected peoples
Authors: Owen John R. , Kemp Deanna , Lechner Alex M. , Harris Jill , Zhang Ruilian , Lèbre Éléonore 
Published: December 2022

AbstractRapidly transitioning the global energy system to renewables is considered necessary to combat climate change. Current estimates suggest that at least 30 energy transition minerals and metals (ETMs) form the material base for the energy transition. The inventory of ETMs indicates a high level of intersectionality with territories less impacted by the historic forces of industrialization. To identify the current global footprint, 5,097 ETM projects were geo-located against indicators for indigeneity, human modification of land, food production, water risk, conflict, as well as capacity measures for project permitting, consultation and consent. Study results differentiate ETMs to improve visibility over linkages between technology, resources and sustainability objectives. Our analysis reveals that more than half of the ETM resource base is located on or near the lands of Indigenous and peasant peoples, two groups whose rights to consultation and free prior informed consent are embedded in United Nations declarations.
Gallionella and Sulfuricella populations are dominant during the transition of boreal potential to actual acid sulfate soils
Authors: Högfors-Rönnholm Eva , Lundin Daniel , Brambilla Diego , Christel Stephan , Lopez-Fernandez Margarita , Lillhonga Tom , Engblom Sten , Österholm Peter , Dopson Mark 
Published: December 2022

AbstractAcid sulfate soils release metal laden, acidic waters that affect the environment, buildings, and human health. In this study, 16S rRNA gene amplicons, metagenomes, and metatranscriptomes all demonstrated distinct microbial communities and activities in the unoxidized potential acid sulfate soil, the overlying transition zone, and uppermost oxidized actual acid sulfate soil. Assembled genomes and mRNA transcripts also suggested abundant oxidized acid sulfate soil populations that aligned within the Gammaproteobacteria and Terracidiphilus. In contrast, potentially acid tolerant or moderately acidophilic iron oxidizing Gallionella and sulfur metabolizing Sulfuricella dominated the transition zone during catalysis of metal sulfide oxidation to form acid sulfate soil. Finally, anaerobic oxidation of methane coupled to nitrate, sulfate, and ferric reduction were suggested to occur in the reduced parent sediments. In conclusion, despite comparable metal sulfide dissolution processes e.g., biomining, Gallionella and Sulfuricella dominated the community and activities during conversion of potential to actual acid sulfate soils.
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin
Authors: Regan Jennifer C. , Lu Yu-Xuan , Ureña Enric , Meilenbrock Ralf L. , Catterson James H. , Kißler Disna , Fröhlich Jenny , Funk Emilie , Partridge Linda 
Published: December 2022

AbstractPharmacological attenuation of mTOR presents a promising route for delay of age-related disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin extends lifespan in females, but not in males. Female-specific, age-related gut pathology is markedly slowed by rapamycin treatment, mediated by increased autophagy. Treatment increases enterocyte autophagy in females, via the H3/H4 histone-Bchs axis, whereas males show high basal levels of enterocyte autophagy that are not increased by rapamycin feeding. Enterocyte sexual identity, determined by transformerFemale expression, dictates sexually dimorphic cell size, H3/H4-Bchs expression, basal rates of autophagy, fecundity, intestinal homeostasis and lifespan extension in response to rapamycin. Dimorphism in autophagy is conserved in mice, where intestine, brown adipose tissue and muscle exhibit sex differences in autophagy and response to rapamycin. This study highlights tissue sex as a determining factor in the regulation of metabolic processes by mTOR and the efficacy of mTOR-targeted, anti-aging drug treatments.
Probing dynamic covalent chemistry in a 2D boroxine framework by in situ near-ambient pressure X-ray photoelectron spectroscopy
Authors: Leidinger Paul , Panighel Mirco , Pérez Dieste Virginia , Villar-Garcia Ignacio J. , Vezzoni Pablo , Haag Felix , Barth Johannes V. , Allegretti Francesco , Günther Sebastian , Patera Laerte L. 
Published: December 2022

Near-ambient pressure X-ray photoelectron spectroscopy enables the in situ observation of polymerization and hydrolysis occurring in an atomically thin boroxine framework on Au(111).
In situ generated aminodiborane as a reagent for deoxygenative reduction of carboxamides to amines
Authors: Nair Abhishek , Tiwari Vikas , Verma Ashutosh , Saini Parul , Elias Anil J. 
Published: December 2022

The in situ generated aminodiborane (μ-NH2B2H5) using NH3BH3 and elemental iodine (I2) is used for the reduction of carboxamides to amines.
Temporal Overlap Between Gestures and Speech in Poststroke Aphasia: Is There a Compensatory Effect?
Authors: Zhang Han , Hinzen Wolfram 
Published: December 2022

Purpose:If language production is impaired, will gestures compensate? Evidence in favor of this prediction has often been argued to come from aphasia, but it remains contested. Here, we tested whether thought content not present in speech due to language impairment is manifested in gestures, in 20 people with dysfluent (Broca’s) aphasia, 20 people with fluent (Wernicke’s) aphasia, and 20 matched neurotypical controls.Method:A new annotation scheme was created distinguishing types of gestures and whether they co-occurred with fluent or dysfluent/absent speech and were temporally aligned in content with coproduced speech.Results:Across both aphasia types, noncontent (beat) gestures, which by their nature cannot compensate for lost speech content, constituted the greatest proportion of all types of gestures produced. Content (i.e., descriptive, referential, and metaphorical) gestures were largely coproduced with fluent rather than dysfluent speech and tended to be aligned with the content conveyed in speech. They also did not differ in quantity depending on whether the dysfluencies were eventually resolved or not. Neither aphasia severity nor comprehension ability had an impact on the total amount of content gesture produced in people with aphasia, which was instead positively correlated with speech fluency.Conclusions:Together, these results suggest that gestures are unlikely to have a role in compensating for linguistic deficits and to serve as a representational system conveying thought content independent of language. Surprisingly, aphasia rather is a model of how gesture and language are inherently integrated and aligned: Even when language is impaired, it remains the essential provider of content.
A Sweet Tutorial to the SUGAR Method of Language Sampling
Authors: Pavelko Stacey L. , Owens Robert E. 
Published: December 2022

Purpose:
The purposes of this tutorial are (a) to describe a method of language sample analysis (LSA) referred to as SUGAR (Sampling Utterances and Grammatical Analysis Revised) and (b) to offer step-by-step instructions detailing how to collect, transcribe, analyze, and interpret the results of a SUGAR language sample.

Method:
The tutorial begins with an overview of current LSA use, including barriers to clinical implementation, followed by an overview of the SUGAR method. Next, the SUGAR method is described in detail, including collecting the sample, transcribing the sample, analyzing the sample, and interpreting the results. To illustrate the method, each section includes an accompanying appendix that provides an example of a sample transcript and the various analyses.

Conclusions:
SUGAR offers speech-language pathologists one way to conduct LSA that is cost free, valid, and efficient. Clinicians can collect, transcribe, and analyze samples in approximately 21 min. The results of a SUGAR analysis can be used to document the presence of a language impairment, obtain a detailed description of a child's conversational language use, identify intervention targets, and develop intervention goals.
The Close AGN Reference Survey (CARS)
Authors: Winkel N. , Husemann B. , Singha M. , Bennert V. N. , Combes F. , Davis T. A. , Gaspari M. , Jahnke K. , McElroy R. , O’Dea C. P. , Pérez-Torres M. A. 
Published: December 2022

Context. The interaction between active galactic nuclei (AGNs) and their host galaxies is scarcely resolved. Narrow-line Seyfert 1 (NLS1) galaxies are believed to represent AGN at early stages of their evolution and to allow one to observe feeding and feedback processes at high black hole accretion rates.
Aims. We aim to constrain the properties of the ionised gas outflow in Mrk 1044, a nearby super-Eddington accreting NLS1. Based on the outflow energetics and the associated timescales, we estimate the outflow’s future impact on the ongoing host galaxy star formation on different spatial scales.
Methods. We applied a spectroastrometric analysis to observations of Mrk 1044’s nucleus obtained with the adaptive-optics-assisted narrow field mode of the VLT/MUSE instrument. This allowed us to map two ionised gas outflows traced by [O III], which have velocities of −560 ± 20 km s−1 and −144 ± 5 km s−1. Furthermore, we used an archival spectrum from the Space Telescope Imaging Spectrograph on HST to identify two Ly-α absorbing components that escape from the centre with approximately twice the velocity of the ionised gas components.
Results. Both [O III] outflows are spatially unresolved and located close to the AGN (< 1 pc). They have gas densities higher than 105 cm−3, which implies that the BPT diagnostic cannot be used to constrain the underlying ionisation mechanism. We explore whether an expanding shell model can describe the velocity structure of Mrk 1044’s multi-phase outflow. In the ionised gas emission, an additional outflowing component, which is spatially resolved, is present. It has a velocity of −211 ± 22 km s−1 and a projected size of 4.6 ± 0.6 pc. Our kinematic analysis suggests that significant turbulence is present in the interstellar medium around the nucleus, which may lead to a condensation rain, potentially explaining the efficient feeding of Mrk 1044’s AGN. Within the innermost 0.5″ (160 pc), we detect modest star formation hidden by the beam-smeared emission from the outflow.
Conclusions. We estimate that the multi-phase outflow was launched < 104 yr ago. Together with the star formation in the vicinity of the nucleus, this suggests that Mrk 1044’s AGN phase started only recently. The outflow carries enough mass and energy to impact the host galaxy star formation on different spatial scales, highlighting the complexity of the AGN feeding and feedback cycle in its early stages.
Design of residential ventilation systems using performance-based evaluation of Indoor Air Quality: application to a Danish study case
Authors: Baptiste Poirier , Jakub Kolarik , Gaëlle Guyot , Woloszyn Monika 
Published: December 2022

A Demand-controlled ventilation (DCV) has been recognized as a promising solution for decreasing energy consumption while ensuring good Indoor Air Quality (IAQ) in buildings. However, its application in the residential sector has increased first recently. Implementation of DCV systems brings the problem related to assessing their performance, not only in the view of energy savings but also in the ability to ensure IAQ. The objectives of this paper were to introduce a multicriteria performance-based approach for the evaluation of residential ventilation systems with CONTAM airflows simulations; illustrate its applicability to three DCV strategies in the context of renovated apartment buildings in Denmark and challenge the minimal background airflow requirements anchored in the Danish building code.
Our performance-based approach allows assessing ventilation performance regarding IAQ (CO2, humidity, PM2.5, and formaldehyde-based indicators), energy consumption, and ventilation heat loss.
Our results show that DCV strategies can improve IAQ while decreasing airflows. For example, application of DCV reduced the cumulative indicator of occupant exposure to formaldehyde, IHCHO by 6 to 28 %, compared to the constant-airflow system. For humidity controlled mechanical exhaust ventilation, the heat loss can be reduced up 51%.