bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Curvotaxis: Can cells surf the waves?
Authors: Milan Jean-Louis , Manifacier Ian , Liu Dongshu , Vassaux Maxime , Pieuchot Laurent , Luchnikov Valeriy , Anselme Karine 
Published: June 2022

Abstract
During, development and regeneration cells are subject to dynamic topographic changes as the surrounding tissues shift and grow. Yet, in vitro experiments have shown that cell scale curvatures influence cell migration, whereby, cells tend to avoid convex peaks and are more likely to settle in concave areas. This behavior was demonstrated on static surfaces with a fixed sinusoidal landscape composed of curved hills-and-valleys. Based on these findings, we later proposed a computer model to theoretically explain the underlying physical mechanism. Nonetheless, how dynamic curvature impacts cell motion remains unknown. In this study, we extend our previous model to explore what would happen if substrate curvature were to change over time. Using travelling wave patterns, we simulate a dynamic surface curvature. We investigate the influence of wave height and wave propagation speed and we find that long-distance cell migration can be achieved. Our results open a new area of study to understand cell mobility in dynamic environments, from single cell in vitro experiments to multi cellular in vivo mechanisms involving embryogenesis and regeneration.
Use the best, ignore the rest: How heuristics allow to tell lie from truth
Authors: Verschuere Bruno , Lin Chu-Chien , Huismann Sara , Kleinberg Bennett , Willemse Marleen , Mei Emily Chong Jia , Goor Thierry van , Löwy Leonie H. S. , Appiah Obed Kwame , Meijer Ewout 
Published: June 2022

Abstract
The failure to detect deception can have grave consequences in politics, relationships, and the court room (Mazar, Amir, & Ariely, 2008). Yet, people are poor lie detectors and perform barely better than chance (Bond & DePaulo, 2006). Understandably, people struggle with integrating the many putative cues to deception into an accurate veracity judgement. Heuristics simplify difficult decisions by ignoring most of the information and relying instead only on the most diagnostic cues (’use the best, ignore the rest’) (Mousavi & Gigerenzer, 2017). We show that people’s deception detection ability can be drastically improved by instructing them to rely solely on the single best available cue. We conducted seven studies in which people evaluated honest and deceptive handwritten statements, video transcripts, videotaped interviews, or live interviews. Participants perform at the chance level when they made an unguided judgment free to use any possible cue. But when instructed to rely only on a single cue (detailedness), they were consistently able to detect deception. The heuristics approach even performed at or above the level of an advanced, more resource-intensive credibility assessment method (Nahari, Vrij, & Fisher, 2014). The simplicity and accuracy of the heuristics approach provides for a novel avenue for deception research and hold promise for practice.
Barriers to Mutational Testing in Patients with Gastrointestinal Stromal Tumors (GIST) – A Survey of Life Raft Group Members
Authors: Montoya Denisse , Call Jerry W. , Eshak Jennily , Knox Pete , Luedke Maeven , Kaur Sahibjeet , Rothschild Sara , Garland Mary , Scherzer Norman J. 
Published: June 2022

Abstract
Background Due to the low mutational testing rate in patients with Gastrointestinal Stromal Tumors (GIST), The Life Raft Group (LRG), a non-profit organization that provides support, advocacy, and conducts research for patients with GIST, analyzed various factors that may have an impact on patients’ ability to receive mutational testing. Methods A survey about mutational testing for patients with GIST, or their caregivers, was conducted in June 2020. The survey, sent to 1004 GIST patients and caregivers through email, was promoted through social media with instructions to contact the LRG to participate. The survey was designed by the LRG Patient Registry Department. Members of the LRG, regardless of Patient Registry status, were eligible to participate. Results A total of 295 patients/caregivers participated in this study (response rate: 29.4%). The percentage of patients who indicated they had received mutational testing was much higher in this survey (80%) than in the general GIST community (26.7%). Several reasons were cited for having a test, including: “My doctor ordered/suggested that I have it done” (54%); “The Life Raft Group advised/suggested I have it done” (25%); “I asked my doctor to have it done” (22%); “I had it done as part of a clinical trial” (5%); “I am not sure” (3%) and “Other” (14%). Mutational testing resulted in a treatment change in 25% of cases. Patients were able to select more than one option when completing this question resulting in a percentage greater than 100.Conclusions The LRG membership is voluntary and proactive; patients who join are more likely to participate in surveys and mutational testing, as well has more likely to have a GIST specialist. Mutational testing can influence understanding a patient’s GIST and the treatment best suited to each case. These are extremely important findings, as it helps ensure that patients are on the proper treatment, which should lead to better outcomes.
Morphological analysis of posterior-medial intertrochanteric fracture patterns using fracture-mapping technique
Authors: Ren Hanru , Qi Xin , Wu Lianghao , Jian Zheng , Zhang Xu , Yi Chengqing 
Published: June 2022

Abstract
Background
The purpose of this study was to analyze the fracture patterns of different posterior-medial wall types of intertrochanteric fractures by 3-D fracture-mapping technique and to further assess their clinical utility.
Methods
In a retrospective analysis of interochanteric fractures treated in a large trauma center, fractures were classified into predesigned groups based on 3D-CT imaging techniques, and a 3-D template of the intertrochanteric region was graphically superimposed on the fracture line. Fracture characteristics were then summarized based on fracture-mapping. Finally, radiographic parameters, function, and range of motion were recorded in different fracture classification states.
Results
A total of 348 intertrochanteric fractures were included. There were 111 patients (31.9%) in the posterolateral + posteromedial + medial group, with the most severe fracture displacement (typically characterized by fragmentation of the posteromedial wall into three isolated fragments). There were 102 cases (29.3%) in the posterolateral + posteromedial + simple medial group, and the most common fracture feature was a complete fragment posteromedially. A total of 81 cases (23.3%) were classified into the posterolateral + medial group, with the medial fracture line extending the anterior fracture line but leaving the lesser trochanter intact. In the isolated medial group of 33 cases (9.5%), the fracture type was similar to type IV, but the integrity of the greater trochanter was ensured. In the posteromedial + medial group of 12 cases (3.4%), the fracture was characterized by an interruption when the fracture line of the anterolateral wall extended to the posteromedial wall, often resulting in a complete isolated fragment posteromedially and medially. There were 9 patients (2.6%) in the isolated posterolateral group. In addition, we found significantly different radiographic scores and range of motion scores between groups.
Conclusions
This morphometric study helps us to further characterize posterior-medial fracture patterns of intertrochanteric fractures, which may be closely related to different clinical outcomes. Further studies are needed to verify the reliability of this classification scheme in clinical application.
Study Design:
Crossover Study Design; Level of evidence, 3.
Nomogram predicting the prognosis of patients with surgically resected stage IA non-small cell lung cancer
Authors: Deng Xu-Feng , Dai Yin , Liu Xiao-Qing , Qi Huang-Zhi , Zhou Dong , Zheng Hong , Li Jiang , Liu Quanxing 
Published: June 2022

Abstract
Background
The American Joint Committee on Cancer(AJCC) 8th stage system was limited in accuracy for predicting prognosis of stage IA nonsmall-cell lung cancer(NSCLC) patients. This study aimed to establish and validate two nomograms that predict overall survival(OS) and lung cancer specific survival(LCSS) in surgically resected stage IA NSCLC patients.
Methods
Postoperative patients with stage IA NSCLC in SEER database between 2004 and 2015 were examined. Survival and clinical information according to the inclusion and exclusion criteria was collected. All patients were randomly divided into the training cohort and validation cohort with a ratio of 7:3. Independent prognosis factors were evaluated using univariate and multivariate Cox regression analyses, and predictive nomogram was established based on these factors. Nomogram performance was measured using the C-index, calibration plots, and DCA. Patients were grouped by quartiles of nomogram scores and survival curves were plotted by Kaplan-Meier analysis.
Results
In total, 33533 patients were included in the study. The nomogram contained 12 prognostic factors in OS and 10 prognostic factors in LCSS. In the validation set, the C-index was 0.652 for predicting OS and 0.651 for predicting LCSS. The calibration curves for the nomogram-predicted probability of OS and LCSS showed good agreement between the actual observation and nomogram prediction. DCA indicated that the clinical value of the nomograms were higher than AJCC 8th stage for predicting OS and LCSS. Nomogram scores related risk stratification revealed statistically significant difference which have better discrimination than AJCC 8th stage.
Conclusions
The nomogram can accurately predict OS and LCSS in surgical resected patients with stage IA NSCLC.
Androgen receptor expression associates with distinctive clinicopathological and molecular features in ER-positive and ER-negative breast cancer
Authors: Hu Taobo , Liu Yiqiang , Zhao Guiyang , Wang Shu , Long Mengping 
Published: June 2022

Abstract
Background
Androgen receptor (AR) expression is frequently observed in breast cancer, but its association with estrogen receptor (ER) expression of breast cancer remains unclear.
Results
In this study, we analyzed the clinicopathological and molecular features associated AR loss in ER-positive and ER-negative breast cancer respectively, trying to elucidate the molecular correlation between AR and ER. Our results showed that AR loss was associated with different clinicopathological characteristics in ER-positive and ER-negative breast cancer. Moreover, the expression of AR was correlated with different molecular features in ER-positive and ER-negative breast cancer.
Conclusions
These results suggest that the role of AR in ER-positive breast cancer is distinctive from that in ER-negative breast cancer.
Role of BLACAT1 in IL-1β-Induced Human Articular Chondrocyte
Apoptosis and Extracellular Matrix Degradation via the miR-149-5p/
HMGCR Axis
Authors: Li Zhiquan , Wang Yingchun , Wu Yaoping , Liu Yanwu , Zhao Yinan , Chen Xiaochao , Li Mo , Zhao Rui 
Published: June 2022

Background:
Osteoarthritis (OA) is an inflammatory joint disorder with high incidence
rates. Long non-coding RNAs (LncRNAs) influence OA development.

Objectives:
In this research, we attempt to figure out the functions of lncRNA BLACAT1 in human
articular chondrocyte (HAC) apoptosis and extracellular matrix (ECM) degradation in OA.

Methods:
Interleukin (IL)-1β was employed to induce HAC damage. Cell viability and apoptosis
were detected, with expression patterns of lncRNA BLACAT1, miR-149-5p, and HMGCR, and
levels of Caspase-3, Caspase-9, BAX, Bcl-2, COL2A1, and SOX9 determined. Then, lncRNA
BLACAT1 was silenced in IL-1β-treated HACs to analyze its role in HAC damage. The target
relations of lncRNA BLACAT1 and miR-149-5p and miR-149-5p and HMGCR were verified. In
addition, combined experiments were performed as a miR-149-5p inhibitor or HMGCR
overexpression was injected into cells with lncRNA BLACAT1 silencing.

Results:
In IL-1β-treated HACs, lncRNA BLACAT1 and HMGCR were overexpressed while miR-
149-5p was poorly expressed, along with reduced cell viability, enhanced apoptosis, elevated
Caspase-3 and Caspase-9 activities, increased BAX level, decreased Bcl-2 level, and declined levels
of COL2A1 and SOX9, which were reversed by lncRNA BLACAT1 silencing. LncRNA
BLACAT1 targeted miR-149-5p, and miR-149-5p targeted HMGCR. miR-149-5p knockout or
HMGCR overexpression annulled the inhibitory role of lncRNA BLACAT1 silencing in HAC
apoptosis and ECM degradation.

Conclusion:
LncRNA BLACAT1 was overexpressed in IL-1β-treated HACs, and the lncRNA
BLACAT1/miR-149-5p/HMGCR ceRNA network promoted HAC apoptosis and ECM degradation.
Multivariate Models of Blood Glucose Prediction in Type1 Diabetes:
A Survey of the State-of-the-art
Authors: Kumar Shailender , Arora Sunny , Kumar Pardeep 
Published: June 2022

Abstract:
Diabetes mellitus is a long term chronicle disorder with a high prevalence rate worldwide. Con-tinuous blood glucose and lifestyle monitoring enabled the control of blood glucose dynamics through machine learning applications using data created by various popular sensors. This survey aims to assess various classical time series, neural networks and state-of-the-art regression models based on a wide variety of machine learning techniques to predict blood glucose and hy-per/hypoglycemia in Type 1 diabetic patients. The analysis covers blood glucose prediction mod-eling, regression, hyper/hypoglycemia alerts, diabetes diagnosis, monitoring, and management. However, the primary focus is on evaluating models for the prediction of Type 1 diabetes. A wide variety of machine learning algorithms have been explored to implement precision medicine by clinicians and provide patients with an early warning system. The automated pancreas may benefit from predictions and alerts of hyper and hypoglycemia.
Molecular Docking, Dynamics Simulation, and Physicochemical Analysis
of Some Phytochemicals as Antiplatelet Agents
Authors: Pourhanafi Shabnam , Gürsoy Vildan Adar 
Published: June 2022

Background:
Antiplatelet drugs are key tools for the prevention and elimination of cardiovascular disease. However, currently available agents are associated with a variety of adverse effects, and new therapeutically effective drugs with fewer or no side effects are urgently needed for effective medication.

Objective:
The present in silico research aimed to determine the inhibitory potential of 50 phytochemicals on platelet function using computational methods.

Methods:
The compounds first were subjected to molecular docking analysis with five chosen antiplatelet targets and the best compound with the lowest energy against each target was selected and analyzed in detail. These complexes were then considered for molecular dynamics simulation and binding free energy analysis. SwissADME and ADMETlab servers were also used to evaluate their drug-likeness and ADMET properties.

Results:
Ligands that exhibited the lowest energy with the corresponding target were: graveolinine
against COX-1, sanguinarine against P2Y12 and PDE-3, rutin against GP-VI, and bisdemethoxycurcumin
against PAR-1. Simulation of these complexes affirmed the binding stability between the ligands and the
proteins. Root mean square deviation and root mean square fluctuation showed that in the case of PAR-1-
bisdemethoxycurcumin, some fluctuations were observed during the simulation process. Calculation of
the binding free energy indicated that in all systems, the van der Waals energy made a significant contribution
to the binding and stability of the system.

Conclusion:
The result of this study could provide useful insights into the development of new lead antiplatelet agents.
A Mini-Review on the Synthesis of Substituted Isatins: From Early Approaches
to Recent Advances with a Specific Focus on Sulfamoyl and
Amino Derivatives
Authors: Temizer Asu Büşra , Koulani Taha , Eter Özge Soylu , Karali Nilgun 
Published: June 2022

Abstract:
As a member of heterocyclic compounds, indole possesses a diverse set of biological activities.
Studies on the structure-activity relationship of 2-indolinones have shown that they are important
bioactive compounds in the field of pharmaceutical chemistry. Isatin and structures bearing isatin scaffold
are derivatives of indole, which have shown to be of biological and pharmacological significance.
This review focuses on different ways of obtaining compounds containing isatin structure, considering
both earlier and recent methods of synthesis. The syntheses given herein were grouped into three categories,
syntheses using anilines as their starting substance, synthetic methods based on the oxidation of
indoles, and finally, due to the extensive research going on 5-substituted isatins and their possible
pharmacological efficacy, pathways for synthesizing 5-amino and 5-sulfamoylisatins were gathered to
underline the importance of 2-indolinone and isatin derivatives as prospective therapeutic compounds
in current and future drug discovery studies.
Screening of Natural Antivirals Against the COVID-19 Pandemic- A
Compilation of Updates
Authors: Goswami Tridib Kumar , De Baishakhi , Raghavan Vijaya G.S. 
Published: June 2022

Background:
Coronavirus disease 2019 (COVID-19), named by WHO, is a public health disaster of the third millennium. This acute respiratory distress syndrome (ARDS) has severe complications like pneumonitis, respiratory failure, shock, multi-organ failure, and finally, death. Despite repurposing of broad-spectrum antivirals, vaccinations, use of mask sanitizers, social distancing, intermittent lockdowns and quarantine, long-term protection or eradication of coronavirus is yet to be achieved.

Objectives:
This comprehensive review makes a compilation of updates on the screening and evaluation of natural antivirals that are found to show anti-COVID potency.

Methods:
Literature mining was done in phytotherapy and food research journals, Pubmed, Scopus, Elsevier for collection of latest research updates focusing on screening and evaluation of anti-COVID natural antivirals.

Results:
In silico molecular docking studies have screened several phytochemicals and food bioactive principles with significant potencies against the corona virus. The anti-COVID potency of the phytochemicals is mostly by restricting the action of enzymes like the main protease (Mpro), 3-chymotrypsin like protease (3CLpro), spike proteins, papain-like protease (ACE2). Free radical scavenging, anti-inflammatory effect, DNA inhibition, prevention of viral attachment, and its penetration into the host body, inhibiting viral replication are other associated mechanisms of bioactive compounds present in plants, vegetables, fruits, spices and marine alga. Different formulations of Ayurveda, Siddha, Unani have shown their ameliorative effects. Many formulations of Traditional Chinese Medicine are under clinical trials.

Conclusions:
The immense potencies of bioactives that are omnipresent need to be properly utilized for immune-boosting and combat this deadly virus naturistically.
Analysis of implementation prevention protocols and community compliance with covid-19 event numbers
Authors: Ajeng Atnesia , Wahidin Wahidin , Oktaviani Ika 
Published: June 2022

<p><strong><em>Background: </em></strong><em>The Covid-19 pandemic has shaken the world community and disturbed all aspects of human life, for this reason our efforts need to be carried out as an effort to prevent and overcome this pandemic so that it will pass quickly. Therefore, it is necessary to implement health and compliance protocols in the community. </em></p><p><strong><em>Objectives: </em></strong><em>The aim of this research is to determine the implementation of COVID 19 prevention protocols and community compliance with covid-19 events in Public Health Center</em></p><pre><strong><em>Methods: </em></strong><em> This research was conducted using regression analysis, correlation and factor analysis. The subjects in this research activity are people who need services at the Puskesmas according to the inclusion and exclusion criteria. The object under study is the community's compliance with the Covid-19 prevention protocol implemented in Tangerang City. A sample of 150 people from 6 Puskesmas in the Tangerang City area in October-November 2020. The main instrument is a questionnaire which is carried out through a blended system approach where research is carried out directly and indirectly in the field, raw data is processed with the help of SPSS and AMOS.</em><em></em></pre><p><strong><em>Results: </em></strong><em>it can be seen that the implementation of the health protocol in the Public Health Center in the Tangerang city area has been running quite well about 58.7%, but the level of compliance of the people of the city of Tangerang is still relatively low about 59.3%, however the incidence rate of Covid-19 in Public Health Center in the city of Tangerang is relatively low namely 70.7%. </em></p><strong><em>Conclusions: </em></strong><em>With the knowledge of the above, it is hoped that the local government and other stakeholders can find out and make the basis of facts in making decisions for further handling in order to accelerate the completion of the Covid-19 pandemic.</em>
Comparison of health education with videos and leaflets on the knowledge of young women about early detection of breast cancer In SMP Negeri 15 Bandung
Authors: Fajriah Wardah , Mandiri Ariyati , Didah Didah , Bestari Astuti Dyah , Gumilang Lani 
Published: June 2022

<p><strong><em>Background: </em></strong><em>Breast cancer is a malignant tumor that grows in the breast tissue and is the most common cancer disease affecting women in Indonesia with an incidence of 42.1 per 100.000 population and an average death rate of 17 per 100.000 population. The increasing incidence of breast cancer in women as adolescents and young adults is due to several factors such as parity at a young age, family history, gene mutations, and poor lifestyle factors. Early detection of breast cancer through education on causative factors and how to prevent breast cancer and breast self-examination technique will be very useful to reduce the incidence. </em></p><p><strong><em>Purpose: </em></strong><em>This study aimed to determine the comparison of breast cancer early detection health education with video and leaflets on the knowledge of young women about early detection of breast cancer.</em><em> </em></p><p><strong><em>Methods: </em></strong><em>This study used a quasi experiment method with two control group design. Samples collected with consecutive sampling techniques. This study conducted for 7 days in December 2019 on young women at SMP Negeri 15 Bandung with 40 subjects in each group. The technique used to collect the data is questionnaire. The experimental group is given with Video and the control group is given with Leaflet. The bivariate data analysis used Paired T-Test and Non-paired T-test. </em></p><p><strong><em>Results: </em></strong><em>The results of this study showed that there was an increase in the knowledge before and after being given video (p = 0.000) and leaflet (0,003) with significant difference in young women who were given video compared to those given leaflets (p=0,000).</em></p><strong><em>Conclusion: </em></strong><em>there were differences in health education with videos and leaflets on the knowledge of young women about early detection of breast cancer.</em>