bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure
Authors: Wang Hui , Yuan Ze , Wang Bianbian , Li Bochuan , Lv Huizhen , He Jinlong , Huang Yaqian , Cui Zhen , Ma Qiannan , Li Ting , Fu Yi , Tan Xiaoli , Liu Yangping , Wang Shengpeng , Wang Changhe , Kong Wei , Zhu Yi 
Published: January 2022

Background:
Vascular endothelial cells are critical for maintaining blood pressure (BP) by releasing biologically active molecules, such as nitric oxide. A non-endothelial cell resident matricellular protein, COMP (cartilage oligomeric matrix protein), plays a pivotal role in maintaining cardiovascular homeostasis, but little is known about its regulatory effect on BP.

Methods:
Mice were infused with AngII (angiotensin II; 450 ng/kg per minute) for 3 days via an osmotic minipump, and BP was monitored by a tail-cuff system. Second-order mesenteric arteries were isolated from mice for microvascular tension measurement. Nitric oxide was detected by an electron paramagnetic resonance technique. Small-interfering RNA transfection, co-immunoprecipitation, bioluminescence resonance energy transfer assays, and patch-clamp electrophysiology experiments were used for further detailed mechanism investigation.

Results:

COMP
−/−
mice displayed elevated BP and impaired acetylcholine-induced endothelium-dependent relaxation compared with wild-type mice with or without AngII. Inhibition of eNOS (endothelial nitric oxide synthase) abolished the difference in endothelium-dependent relaxation between wild-type and COMP
−/−
mice. Furthermore, COMP directly interacted with the C-terminus of Piezo1 via its C-terminus and activated the endogenous Piezo1 currents, which induced intracellular Ca
2+
influx, Ca
2+
/calmodulin-dependent protein kinase type II and eNOS activation, and nitric oxide production. The Piezo1 activator, Yoda1, reduced the difference in endothelium-dependent relaxation and BP in wild-type and COMP
−
/−
mice. Moreover, COMP overexpression increased eNOS activation and improved endothelium-dependent relaxation and BP.

Conclusions:

Our study demonstrated that COMP is a novel Piezo1 regulator that plays a protective role in BP regulation by increasing cellular Ca
2+
influx, eNOS activity, and nitric oxide production.
Health Screening Program to Enhance Enrollment of Women and Minorities in CREST-2
Authors: Lal Brajesh K. , Meschia James F. , Jones Michael , Aronow Herbert D. , Lackey Angelica , Lake Rachel , Howard George , Brott Thomas G. 
Published: January 2022

Background and Purpose:
The CREST-2 (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial) consists of 2 parallel randomized stroke prevention trials in patients with asymptomatic high-grade stenosis of the cervical carotid artery. The purpose of this report is to detail the outcomes of a health screening effort to increase trial enrollment of women and minorities.

Methods:
Life Line screening (LLS) conducts nationwide screening for vascular disease. Screenings within a 50-mile radius of each CREST-2 center were identified for participation in a joint CREST-LLS program over the course of one year (November 2018 to October 2019) whereby patients with an abnormal carotid ultrasound were referred to the local CREST-2 center for further workup, management, and potential consideration for trial enrollment.

Results:
LLS completed the screening of 588 198 individuals in 29 732 zip codes across the United States. Of those, 230 021 individuals were screened at events occurring near a CREST-2 clinical center and 646 (0.3%) were found to have abnormal carotid ultrasound findings. Each of the 646 individuals was contacted by CREST-LLS program staff for permission to be referred to their local CREST-2 center; 200 (31%) consented to be contacted by CREST-2. Of those, 39 (19.5%) agreed to be, and were, evaluated at their local CREST-2 center. High-grade stenosis was confirmed in 27 patients. A total of 3 patients were eligible for the trial and were enrolled, one woman but no racial/ethnic minorities.

Conclusions:
The LLS program appears to identify community-living individuals with high-grade carotid stenosis through ultrasonography. However, the prevalence of abnormal carotid findings was low. In addition, screening and offering participation into the CREST-2 trial had no substantial impact on the proportion of women and minorities enrolled in the trial. Additional innovative strategies are needed to promote enrollment of diverse patients with carotid stenosis into stroke prevention trials.
Nothing Personal: Blavatsky and Her Indian Interlocutors
Authors: Chajes Julie 
Published: January 2022

Abstract
The Theosophical Society was an influential transnational religious movement founded by H. P. Blavatsky and others in 1875. With its theology of the impersonal Divine, Theosophy was particularly influential on the New Age, which inherited a propensity to see the divine in impersonal terms. Offering a corrective to the recent historiographical tendency that focuses solely on Theosophy’s Western aspects, this article analyzes Blavatsky’s written “conversations” on the nature of the Divine with two Indian Theosphists, T. Subba Row (1856–1890) and Mohini Chatterji (1858–1936). Contextualizing these discussions both globally and locally, it reveals Blavatsky’s engagement with Subba Row’s Vedantic reading of John Stuart Mill and her concurrent rejection of Mohini’s Brahmo-Samaj inspired theism. The article considers the power dynamics that lay behind these negotiations. It argues that they involved a mutual drive for legitimacy and were the result of complex transcultural encounters that resist reductionist historiographical tendencies.
Stab resistance of flexible composite reinforced with warp-knitted fabric like scale structure at quasi-static loading
Authors: Liu Qing , LanlanWang  , Luo Min , Wu Qian , Kang Yong , Ma Pibo 
Published: January 2022

The stab-resistant fabric like scale structure has a promising application prospect for areas of stab prevention owing to its great flexibility and excellent stab-resistance performance. In this paper, a kind of novel stab-resistant fabric has been designed by coating with epoxy resin (ER) and silicon carbide (SiC) particles, which was based on the warp-knitted fabric like scale structure (WKFS). The uniformity of dispersion has been investigated with different diameter and mass fraction of SiC, and polymerization degree of polyglycols (PEG); the flexibility and quasi-static properties of different kinds of WKFS treated with different coating solution has been studied, and the coating solution was prepared by mixing SiC particles and ER at different ratios. The results showed that the dispersion uniformity of the dispersion was the best when the diameter of SiC is 1 μm, the content is 50%, and the polymerization degree of PEG is 600. The longitudinal flexibility of the stab-resistant fabric is greater than that of transverse due to the gap between the longitudinal scales, and the addition of SiC particles can increase the transverse and longitudinal flexibility of stab-resistant fabric, and the flexible properties were the greatest when SiC:ER = 50:30. In addition, the WKFS treated with SiC of 16.7% has fatigue resistance; the damage mechanism of the fabric treated with pure ER is thankful to the brittleness of the resin; the added SiC particles hinder the further crack propagation of the resin, and the failure mode is mainly in stretch.
Promise and peril-defining ethical telehealth practice from the clinician and patient perspective: A qualitative study
Authors: Keenan Amanda Jane , Tsourtos George , Tieman Jennifer 
Published: January 2022

Objectives We undertook a qualitative study to examine and compare the experience of ethical principles by telehealth practitioners and patients in relation to service delivery theory. The study was conducted prior to and during the recent global increase in the use of telehealth services due to the COVID-19 pandemic, Methods We conducted semi-structured interviews with 20 telehealth practitioners and patients using constructionist grounded theory methods to collect and analyse data. Twenty-five axial coded data categories were then unified and aligned through selective coding with the Beauchamp and Childress (2013) framework of biomedical ethics. The groups were then compared. Results Thirteen categories aligned to the ethical framework were identified for practitioners and 12 for patients. Variance existed between the groups. Practitioner results were non-maleficence 4/13 or (31%), beneficence 4/13 (31%), professional–patient relationships 3/12 (22%), autonomy 1/13 (8%) and justice 1/13 (8%). Patient data results were non-maleficence 4/12 (33%), professional–patient relationships 3/12 (33%), autonomy 2/12 (18%), beneficence 1/12 (8%) and justice 1/12 (8%). Conclusions Ethical principles are experienced differently between telehealth practitioners and patients. These differences can impact the quality and safety of care. Practitioners feel telehealth provides better care overall than patients do. Patients felt telehealth may force a greater share of costs and burdens onto them and reduce equity. Both patients and practitioners felt telehealth can be more harmful than face-to-face service delivery when it creates new or increased risk of harms. Building sufficient trust and mutual understanding are equally important to patients as privacy and confidentiality.
Embedded Micro-detectors for EUV Exposure Control in FinFET CMOS Technology
Authors: Wang Chien-Ping , Lin Burn Jeng , Wu Pin-Jiun , Shih Jiaw-Ren , Chih Yue-Der , Chang Jonathan , Lin Chrong Jung , King Ya-Chin 
Published: January 2022

AbstractAn on-wafer micro-detector for in situ EUV (wavelength of 13.5 nm) detection featuring FinFET CMOS compatibility, 1 T pixel and battery-less sensing is demonstrated. Moreover, the detection results can be written in the in-pixel storage node for days, enabling off-line and non-destructive reading. The high spatial resolution micro-detectors can be used to extract the actual parameters of the incident EUV on wafers, including light intensity, exposure time and energy, key to optimization of lithographic processes in 5 nm FinFET technology and beyond.
Gene regulation network analyses of pistil development in papaya
Authors: Liao Zhenyang , Dong Fei , Liu Juan , Xu Lele , Marshall-Colon Amy , Ming Ray 
Published: January 2022

Abstract
Background
The pistil is an essential part of flowers that functions in the differentiation of the sexes and reproduction in plants. The stigma on the pistil can accept pollen to allow fertilization and seed development. Papaya (Carica papaya L.) is a dioecious plant, where female flowers exhibit normal pistil, while the male flowers exhibit aborted pistil at a late stage of pistil development.

Results
The developmental stages of papaya pistil were analyzed after first dividing it into slices representing the primordium stage 1 (S1), the pre-meiotic stages S2, post-meiotic stage S3, and the mitotic stage S4. The SS scoring algorithm analysis of genes preferentially expressed at different stages revealed differentially expressed genes between male and female flowers. A transcription factor regulatory network for each stage based on the genes that are differentially expressed between male and female flowers was constructed. Some transcription factors related to pistil development were revealed based on the analysis of regulatory networks such as CpAGL11, CpHEC2, and CpSUPL. Based on the specific expression of genes, constructed a gene regulatory subnetwork with CpAGL11-CpSUPL-CpHEC2 functioning as the core. Analysis of the functionally enriched terms in this network reveals several differentially expressed genes related to auxin/ brassinosteroid signal transduction in the plant hormone signal transduction pathway. At the same time, significant differences in the expression of auxin and brassinosteroid synthesis-related genes between male and female flowers at different developmental stages were detected.

Conclusions
The pistil abortion of papaya might be caused by the lack of expression or decreased expression of some transcription factors and hormone-related genes, affecting hormone signal transduction or hormone biosynthesis. Analysis of aborted and normally developing pistil in papaya provided new insights into the molecular mechanism of pistil development and sex differentiation in dioecious papaya.
Automatic exposure compensation in intraoral digital radiography: effect on the gray values of dental tissues
Authors: Maciel Evelyn Rute Carneiro , Nascimento Eduarda Helena Leandro , Gaêta-Araujo Hugo , Pontual Maria Luiza dos Anjos , Pontual Andrea dos Anjos , Ramos-Perez Flávia Maria Moraes 
Published: January 2022

Abstract
Background
This study aimed to investigate the effect of automatic exposure compensation (AEC)
of intraoral radiographic systems on the gray values of dental tissues in images acquired with or without high-density material in the exposed region using different exposure times and kilovoltages. The influence of the distance of the high-density material was also investigated.

Methods
Radiographs from the molar region of two mandibles were obtained using the RVG 6100 and the Express systems, operating at 60 and 70 kV and 0.06, 0.10, and 0.16 s. Subsequently, a titanium implant was inserted in the premolar’s socket and other images were acquired. Using the ImageJ software, two regions of interest were determined on the enamel, coronary dentine, root dentine, and pulp of the first and second molars to obtain their gray values.

Results
In the RVG 6100, the implant did not affect the gray values (p > 0.05); the increase in kV decreased it in all tissues (p < 0.05), and the exposure time affected only the root dentine and pulp. In the Express, only enamel and coronary dentine values changed (p < 0.05), decreasing with the implant presence and/or with the increase in exposure factors. The distance of the implant did not affect the results (p > 0.05).

Conclusions
AEC’s performance varies between the radiographic systems. Its effect on the gray values depends not only on the presence or absence of high-density material but also on the kV and exposure time used.
Mediators of screening uptake in a colorectal cancer screening intervention among Hispanics
Authors: Shokar Navkiran K. , Salinas Jennifer , Dwivedi Alok 
Published: January 2022

Abstract
Background
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the USA. Although a number of CRC screening tests have been established as being effective for CRC prevention and early detection, rates of CRC screening test completion in the US population remain suboptimal, especially among the uninsured, recent immigrants and Hispanics. In this study, we used a structural equation modelling approach to identify factors influencing screening test completion in a successful CRC screening program that was implemented in an uninsured Hispanic population. This information will enhance our understanding of influences on CRC screening among historically underscreened populations.

Methods
We used generalized structural equation models (SEM) utilizing participant reported information collected through a series of surveys. We identified direct and indirect pathways through which cofactors, CRC knowledge and individual Health Belief Model constructs (perceived benefits, barriers, susceptibility, fatalism and self-efficacy) and a latent psychosocial health construct mediated screening in an effective prospective randomized CRC screening intervention that was tailored for uninsured Hispanic Americans.

Results
Seven hundred twenty-three participants were eligible for inclusion; mean age was 56 years, 79.7% were female, and 98.9% were Hispanic. The total intervention effect was comparable in both models, with both having a direct and indirect effect on screening completion (n = 715, Model 1: RC = 2.46 [95% CI: 2.20, 2.71, p < 0.001]; n = 699, Model 2 RC =2.45, [95% CI: 2.18, 2.72, p < 0.001]. In Model 1, 32% of the overall effect was mediated by the latent psychosocial health construct (RC = 0.79, p < 0.001) that was in turn mainly influenced by self-efficacy, perceived benefits and fatalism. In Model 2, the most important individual mediators were self-efficacy (RC = 0.24, p = 0.013), and fatalism (RC = 0.07, p = 0.033).

Conclusion
This study contributes to our understanding of mediators of CRC screening and suggests that targeting self-efficacy, perceived benefits and fatalism could maximize the effectiveness of CRC screening interventions particularly in Hispanic populations.
Observations and conversations: how communities learn about infection risk can impact the success of non-pharmaceutical interventions against epidemics
Authors: Silk Matthew J. , Carrignon Simon , Bentley R. Alexander , Fefferman Nina H. 
Published: January 2022

AbstractBackgroundIndividual behavioural decisions are responses to a person’s perceived social norms that could be shaped by both their physical and social environment. In the context of the COVID-19 pandemic, these environments correspond to epidemiological risk from contacts and the social construction of risk by communication within networks of friends. Understanding the circumstances under which the influence of these different social networks can promote the acceptance of non-pharmaceutical interventions and consequently the adoption of protective behaviours is critical for guiding useful, practical public health messaging.MethodsWe explore how information from both physical contact and social communication layers of a multiplex network can contribute to flattening the epidemic curve in a community. Connections in the physical contact layer represent opportunities for transmission, while connections in the communication layer represent social interactions through which individuals may gain information, e.g. messaging friends.ResultsWe show that maintaining focus on awareness of risk among each individual’s physical contacts promotes the greatest reduction in disease spread, but only when an individual is aware of the symptoms of a non-trivial proportion of their physical contacts (~ ≥ 20%). Information from the social communication layer without was less useful when these connections matched less well with physical contacts and contributed little in combination with accurate information from physical contacts.ConclusionsWe conclude that maintaining social focus on local outbreak status will allow individuals to structure their perceived social norms appropriately and respond more rapidly when risk increases. Finding ways to relay accurate local information from trusted community leaders could improve mitigation even where more intrusive/costly strategies, such as contact-tracing, are not possible.
Determinants of complex regional pain syndrome type I in patients with scaphoid waist fracture- a multicenter prospective observational study
Authors: Gong Hao , Zhao Gang , Liu Yuzhou , Lu Zhengfeng 
Published: January 2022

Abstract
Background
The aim of this prospective study was to assess the incidence of complex regional pain syndrome type I (CRPS I) in patients with scaphoid waist fracture and to explore associated factors.

Methods
This was a multicenter, prospective observational study. Demographic, imaging indicators and clinical data were collected before the conservative treatment of scaphoid waist fracture patients. The occurrence of CRPS I and pain condition were the main outcomes. To explore the factors associated with CRPS I, multivariate logistic regression model was used.

Results
A total of 493 scaphoid waist fracture participants undergoing conservative treatment were recruited for this study. The incidence of CRPS I was 20% (n = 87). The average time between injury and the onset of CRPS I was 6.7 ± 2.1 weeks. Multivariable logistic regression analysis revealed that female sex (odds ratio (OR): 1.669; 95% confidence interval (CI): 1.189–2.338), diabetes mellitus (OR: 3.206; 95% CI: 2.284–4.492), and severe pain condition before treatment (visual analog scale (VAS) score more than 4 cm) (OR: 27.966; 95% CI: 19.924–39.187) were independently associated with CRPS I.

Conclusions
Patients suffering from scaphoid waist fracture may be at a higher risk of CRPS I, especially in women with diabetes mellitus who report severe pain before treatment. Early screening and regular follow up evaluation are recommended in these patients.
Co-option of the limb patterning program in cephalopod eye development
Authors: Neal Stephanie , McCulloch Kyle J. , Napoli Francesca R. , Daly Christina M. , Coleman James H. , Koenig Kristen M. 
Published: January 2022

Abstract
Background
Across the Metazoa, similar genetic programs are found in the development of analogous, independently evolved, morphological features. The functional significance of this reuse and the underlying mechanisms of co-option remain unclear. Cephalopods have evolved a highly acute visual system with a cup-shaped retina and a novel refractive lens in the anterior, important for a number of sophisticated behaviors including predation, mating, and camouflage. Almost nothing is known about the molecular-genetics of lens development in the cephalopod.

Results
Here we identify the co-option of the canonical bilaterian limb patterning program during cephalopod lens development, a functionally unrelated structure. We show radial expression of transcription factors SP6-9/sp1, Dlx/dll, Pbx/exd, Meis/hth, and a Prdl homolog in the squid Doryteuthis pealeii, similar to expression required in Drosophila limb development. We assess the role of Wnt signaling in the cephalopod lens, a positive regulator in the developing Drosophila limb, and find the regulatory relationship reversed, with ectopic Wnt signaling leading to lens loss.

Conclusion
This regulatory divergence suggests that duplication of SP6-9 in cephalopods may mediate the co-option of the limb patterning program. Thus, our study suggests that this program could perform a more universal developmental function in radial patterning and highlights how canonical genetic programs are repurposed in novel structures.