bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of uro-oncology practice and robot-assisted surgery during the peak of COVID-19 pandemic
Authors: Dev Preetham , Yuvaraja T. B. , Waigankar Santosh S. , Ranade Sharmila , Pednekar Abhinav P. , Agarwal Varun , Khandekar Archan , Badlani Naresh , Asari Ashish 
Published: November 2022

Aim:
The pandemic by novel coronavirus disease 2019 (COVID-19) is the biggest threat to global health care. Routine care of cancer patients is affected the most. Our institute, situated in Mumbai, declared as the hotspot of COVID-19 in India, continued to cater to the needs of cancer patients. We did an observational study to review the experience of managing uro-oncology patients and who underwent either open, endoscopic, or robot-assisted surgery for urological malignancy.

Materials and Methods:
During the peak of COVID-19 pandemic from March 21, 2020, to June 21, 2020, all the uro-oncology cases managed in our tertiary care hospital were analyzed. Teleconsultation was started for follow-up patients. All patients requiring surgery underwent reverse transcription-polymerase chain reaction for COVID-19. Institutional protocol was formulated based on existing international guidelines for patient management. Adequate personal protection and hydroxychloroquine prophylaxis were provided to health-care professionals.

Results:
During the study period, 417 outpatient consultations were made. Forty-nine patients underwent surgery for different urological malignancies. Majority of the surgeries were robot-assisted surgeries (59.2%, 29 patients), followed by endoscopic procedures (28.5%, 14 patients) and few open procedures (10.2%, five patients). Most of our patients were elderly males (mean, 62.5 years). With a median follow-up of 55 days (interquartile range, 32–77), there was no report of COVID-19 infection in any patient or health-care provider.

Conclusions:
We can continue treating needy cancer patients with minimal risk by taking all precautions. Our initial experience of managing uro-oncology cases during this pandemic is encouraging. Robotic surgeries can be safely performed.
A randomized study for dosimetric assessment and clinical impact of bone marrow sparing intensity-modulated radiation therapy versus 3-dimensional conformal radiation therapy on hematological and gastrointestinal toxicities in cervical cancer
Authors: Kapoor Ankita Rungta , Bhalavat Rajendra L , Chandra Manish , Pareek Vibhay , Moosa Zaiba , Markana Saurabh , Nandakumar P. , Bauskar Pratibha , Shincy N. V. 
Published: November 2022

Background:
Cervical cancer requires multimodality therapy, resulting in acute toxicities. Intensity-modulated radiation therapy (IMRT) is postulated to spare bone marrow (BM) and bowel to reduce acute hematological and gastrointestinal (GI) toxicities of chemoradiotherapy.

Patients and Methods:
This is a prospective randomized phase III study enrolling patients with Stage IB to IVA cervical carcinoma in two arms receiving either three-dimensional conformal radiotherapy (3DCRT) or IMRT from December 2017 to December 2019. The primary objective was to compare the hematologic toxicities (Grade 2 or more neutropenia as the primary factor) and the secondary objectives were to compare GI toxicities, and dosimetric analysis for volumes of BM, and bowel irradiated. SPSS version 20 was used for all statistical calculations.

Results:
Eighty patients with histopathologically confirmed cervical cancer were randomized to receive IMRT or 3DCRT (40 in each arm). The median age of the patients was 56.5 (36–67) and 59.5 (37–68) years, respectively, in IMRT and 3DCRT arms. The median dose of external radiation was 50 Gy in 25 fractions, and of brachytherapy was 24 Gy in 3 fractions in both the arms. The incidence of grade ≥2 neutropenia was 42.5% and 15% in the 3DCRT and IMRT arms, respectively (P < 0.001). All patients received concurrent chemotherapy with cisplatin, with the median number of cycles being 5 (range 3–5) in both the arms. All five cycles of concurrent chemotherapy could be completed in 25 (62.5%) patients in the IMRT arm and 24 (60%) patients in the 3DCRT arm.

Conclusions:
IMRT significantly reduces acute hematologic and GI toxicities compared with 3DCRT with a better dosimetry profile.
Development and validation of an indigenous, radiobiological model-based tumor control probability and normal tissue complication probability estimation software for routine plan evaluation in clinics
Authors: Patel Ganeshkumar , Mandal Abhijit , Bharati Avinav , Choudhary Sunil , Mishra Ritusha , Mourya Ankur 
Published: November 2022

Purpose:
Development and validation of a simple and convenient computational program in MATLAB environment for estimating the tumor control probability (TCP) and the normal tissue complication probability (NTCP), as a decision support system for routine plan evaluation.

Materials and Methods:
We developed an in-house software using MATLAB 2016b (Mathworks) for estimating TCP and NTCP named as RBMODELV1. The program contains Niemierko free equivalent uniform dose (EUD) program code provided in authors research article. For rest of radiobiological (RB) models in the software separate coding is performed. The program accepts cumulative dose–volume histogram file in (.txt) format containing two columns dose and volume. A set of two RB parameters were prepared, default and user-dependent in excel sheet named as RBDATA. We cross-validated results of RBMODELV1 software with BioSuite software for Poisson's TCP model and Lyman-Kutcher-Burman (LKB) model. A set of total 20 patient's data of head and neck site took under study and respective TCP and NTCP calculated by all the RB models and compared.

Results:
This is the first study in which we tried to establish correlation between the mean doses (EUD) received by parallel structure (parotid gland and oral cavity) and predicted percentage of NTCP values. It is found that mean dose in the range of 35–40 Gy for parotid gland can result in more than 50% NTCP predicted by all four RB models. Similarly oral cavity receiving mean dose in the range of 53–58 Gy can results in more than 35% NTCP predicted by all the four models. There is <3% variation observed between TCP calculated by BioSuite and RBMODELV1 software and <4% variation observed between predicted NTCP for parotid gland and oral cavity OAR from LKB model by both the software.

Conclusion:
We created simple software RBMODELV1 which can be used as a research tool as well as decision support system.
Dysregulated claudin expression significantly effect breast cancer disease progression
Authors: Fatima Zunaira , Riaz Syeda Kiran , Khan Jahanghir Sarwar , Haq Farhan , Malik Muhammad Faraz Arshad 
Published: November 2022

Background:
In this study, the role of claudins in cancer progression was explored among breast cancer-affected women.

Methodology:
Two cohorts (discovery and validated) of breast cancer-affected women were used. In discovery cohort, 90 freshly excised breast tumor tissues along with adjacent cancer free specimens were collected at the time of surgery. These specimens were processed for RNA isolation and complementary DNA synthesis. After designing primers for claudin 3, claudin 4, and claudin 7, these sequences were synthesized from Macrogen, Korea. Claudin expression in respective tumors and controls was assessed using quantitative reverse transcription polymerase chain reaction. Any probable correlation of these molecules with various clinicopathological parameters was explored. For validation, a publicly available dataset of 2088 breast cancer patients was accessed. Claudin expression of these patients was analyzed for given clinical parameters and compared with earlier findings of discovery cohort.

Results:
Discovery cohort comprised 17% luminal A, 63% luminal B, 8% human epidermal growth factor receptor 2 enrich, and 12% triple-negative breast cancer tumor. High claudin 3 expression was significantly correlated with tumor size >2 cm and menopausal status. Claudin 7 expression was upregulated among poorly differentiated tumor patients. Both claudins 3/4 showed significant correlation with tumor grade, stage, size, and metastasis. Claudin-low subtype was also found in 18% of the cohort.

Conclusion:
Claudins impart a significant role in cell differentiation and disease progression. Hence, claudin cluster can be ascertained as the disease biomarkers for breast cancer.
Globalización, TIC y Educación Superior: trilogía para un análisis internacional desde un enfoque de ciencia, tecnología y sociedad
Authors: Joao Pedro Antonio Joaquim 
Published: November 2022

El objetivo del presente trabajo es realizar una referencia actualizada de autores que abordan la temática referida a la relación que se establece entre la trilogía: Globalización, TIC y Educación Superior, desde una mirada de Ciencia, Tecnología y Sociedad. Para ello se parte del fenómeno actual de la globalización que ocurre con el desarrollo de las tecnologías y el impacto que tiene en los sistemas educativos en general particularizando la universidad contemporánea. También se analizan temas de actualidad como es la Brecha Digital existente entre países con diferentes niveles de desarrollo, el reto de incorporar las TIC en las universidades a partir de los componentes humanos y tecnológicos necesarios. De igual forma se aborda los problemas asociados al uso indebido de las tecnologías y su impacto social, educativo y ético. Uno de los elementos más significativos que se evidencian es el proceso de transición de la sociedad de la información hacia una nueva sociedad de la inteligencia, vista esta última como un proceso donde la información es evaluada por los usuarios de las redes telemáticas. Se demuestra la necesidad de capacitar a profesores y estudiantes en función de incorporar las TIC en la universidad de forma consciente, planificada y eficiente.
SOFTWARE GUIDED NAVIGATION OF CORONARY WIRE FOR CHRONIC TOTAL OCCLUSION RECANALIZATION: A BENCH STUDY OF NAVIWIRE APPLICATION
Authors: Suleman Muhammad 
Published: November 2022

Objectives: Chronic Total Occlusion usually requires specialized wires. These specialized wires should not be rotated haphazardly and as this can lead to rotation of wire inside subintimal space and leading to creation of large subintimal space and collapse of main lumen and making difficult wire reentry. Only controlled and intentional rotation of wire is necessary for higher procedural success. Coronary arteries are 3 dimensional structures and fluoroscopy has limitation to locate the wire in three dimensional vessels. 3D wiring is one method for accurate guidewire location in CTO lesions. Previously some authors have proposed methods to make a mental picture of 3D wiring. In order to make this process even less cumbersome. We propose a software application named NAVIWire that does the job in cath-lab with in two steps. The purpose of this study is to assess the accuracy of our software to locate a wire shaft and tip inside 3D printed coronary vessel.
Methodology: A 3D printed coronary vessel is printed in such a way that it is divided into 9 quadrants. One operator inserted wire into one of these quadrants. The wire had 1mm tip bend like use in CTO. This operator knew the location of wire and tip orientation. Operator 2 (first time user) and operator (expert user) who were blinded to original location imaged this model under biplane fluoroscope using LAO 45 and RAO 45. The process was repeated 36 times and randomly the first operator changed the location and orientation of tip each time. They inserted the data from these two views into the NAVIWire software and it output the predicted location of wire in these quadrant and tip orientation. We compared this predicted location with original location. We also reported inter-observer variability between first time user and expert user. In addition, we also reported a case of successful crossing of LAD CTO using NAVIWire software. This case report will help operators understand the usage of NAVIWire in real life settings.
Results: The location of wire shaft inside all 9 quadrants was 100% correctly predicted by all operators. Although the expert user (operator 2) correctly predicted the tip orientation all 36 times but first time user predicted with 94.4% accuracy. The case report of patient shows successful crossing of CTO wire using NAVIWire assisted 3D wiring.
Conclusion: NAVIWire correctly predicts CTO wire location and tip orientation in 3D printed coronary vessel and the case report also reiterate the finding in real life setting.
COMPARISON OF CLINICAL OUTCOMES OF CALCIFIED AND NON-CALCIFIED CORONARY ARTERY LESION INTERVENTION UNDER IVUS GUIDANCE -AN EXPERIENCE FROM A SOUTH ASIAN COUNTRY, PAKISTAN
Authors: Ihsanullah Ihsanullah , Rahman Nasir , Nasir Ayesha , Adnan Ghufran , Farhad Awais , Saeed Yawer , Khan Maria 
Published: November 2022

Objectives: Intralesional coronary artery calcification (CAC) is an important prognostic marker in terms of target lesion failure, target vessel revascularization and clinical outcomes. Intravascular ultrasound (IVUS) plays a pivotal role in the optimal management of calcified coronary arteries. We aimed to determine the clinical outcomes of IVUS guided intervention of calcified coronary lesions in a South Asian country.
Methodology: We retrospectively studied a total of 134 consecutive patients, who underwent IVUS guided assessment of coronary arteries from January 2013 to March 2020 at a single center. Patients were categorized into two groups: those with coronary artery calcification (CAC, n=77) and without coronary artery calcification (non-CAC, n=57). The mean duration of follow-up was 40.3 ± 30.1 months. The two groups were compared based on their clinical characteristics, management, in-hospital events, follow-up, and major adverse cardiac events (MACEs) that included cardiovascular death, non-fatal MI, life-threatening arrhythmia, bleeding, heart failure, stroke, and target vessel revascularization.
Results: A total of 134 patients were included who had undergone IVUS and were divided into two groups patients with CAC (n=77) and non-CAC (n=57). Majority of the patients were male (n=97 [72.3%]), the mean age at presentation was 63.1 ± 12.9 years. In CAC group the most common risk factor was Age of the patient then dyslipidemia (n=68[88%] followed by hypertension (n=64[83%]) and diabetes mellitus (n=44[57%]), CAC group patients were more commonly presented with acute coronary syndrome (n=59[76.6%]), had prior PCI (n=40[52%]), had more LM disease (n=34 [44%], p=value 0.005), significant number of prior stent-ISR (n=27[47%]) p=0.024. Having CAC is associated with higher MACE (17 out of 26 events).
Conclusion: Patients with CAC have more comorbidities and more commonly present with acute coronary syndrome. MACEs were recorded higher in the CAC group although the results are not statistically significant.
EFFECT OF DIFFERENT RATIO OF PROTEIN AND CARBOHYDRATES ON THE PHYSIOLOGICAL STATE AND PRODUCTIVITY OF YOUNG BULLS
Authors: RADCHIKOVA G. N. , KOT A. N. , SAPSALEVA T. L. , GLINKOVA A. M. , PILIUK N. V. , DOLZHENKOVA E. A. , VOZMITEL L. A. , LEMESHEVSKY V. О. , RAYKHMAN A. Y. , GOLUBITSKIY V. A. , KOPYTKOV V. V. , KOVALENKO S. A. , BROSHKOV M. M. , DANCHUK A. V. , ZINOVEV S. G. 
Published: November 2022

In the process of scientific work, the effect of extruded mixture of concentrates with a high content of degradable protein and non-structural carbohydrates on indicators of rumen digestion, productivity and efficiency of the dietary feed was studied.
The objects of the study were black-and-white bulls at the age of 3-6 months. It was found that feeding them with grain mixture subjected to barothermic treatment contributed to a better growing capacity and efficiency of using nutrients in the diet. As
a result, live weight gain in animals of the experimental group was 5.8 % higher than in the control group, and feed costs were 3.2 % lower.
principales problemas
Authors: IUDOP  
Published: November 2022

Entre la última quincena de agosto y la primera semana de septiembre se realizó una encuesta de opinión pública entre una muestra de 1,303 adultos, representativa de la población total de El Salvador, con un margen de error del 4 por ciento. Los resultados se refieren a lo que la población salvadoreña espera que haga el futuro gobierno para solucionar sus problemas principales. Así, los salvadoreños esperan que el próximo gobierno aumente la vigilancia y haga cumplir la ley contra la delincuencia, que abra fuentes de trabajo y controle los precios para enfrentar el problema económico, y, finalmente, que aumente los recursos destinados a la salud pública.
ECA Estudios Centroamericanos, Vol. 48, No. 539, 1993: 841-854.
EDUCAÇÃO INFANTIL E O DESENVOLVIMENTO DA PERSONALIDADE DA CRIANÇA
Authors: Teixeira Rosana de Souza , Sena Jaqueline Miranda de 
Published: November 2022

O objetivo deste artigo é analisar o impacto da educação infantil no desenvolvimento da personalidade da criança. A análise bibliográfica foi a principal ferramenta metodológica na elaboração deste artigo, muito importante para compreender os conceitos de desenvolvimento da personalidade e refletir sobre o processo escolar nos primeiros anos de vida. Também são discutidos os objetivos, características, planos e atividades da educação infantil e a reflexão do trabalho educativo como processo objetivo e sistemático. Essa forma de aprender favorece o desenvolvimento dos valores, hábitos e práticas dos professores em sala de aula. O trabalho do professor é influenciar e direcionar a atitude do aluno em relação ao comportamento, que é um traço de personalidade desenvolvido na escola.
Improving models to predict holocellulose and Klason lignin contents for peat soil organic matter with mid-infrared spectra
Authors: Teickner Henning , Knorr Klaus-Holger 
Published: November 2022

Abstract. To understand global soil organic matter (SOM) chemistry and its dynamics, we need tools to efficiently quantify SOM properties, for example, prediction models using mid-infrared spectra. However, the advantages of such models rely on their validity and accuracy. Recently, Hodgkins et al. (2018) developed models to quantitatively predict peat holocellulose and Klason lignin contents, two indicators of SOM stability and major fractions of organic matter. The models may help to understand large-scale SOM gradients and have been used in various studies. A research gap to fill is that these models have not been validated in detail yet. What are their limitations and how can we improve them? This study provides a validation with the aim to identify concrete steps to improve these models. As a first step, we provide several improvements using the original training data. The major limitation we identified is that the original training data are not representative for a range of diverse peat samples. This causes both biased estimates and extrapolation uncertainty under the original models. In addition, the original models can in practice produce unrealistic predictions (negative values or values >100 mass-%). Our improved models partly reduce the observed bias, have a better predictive performance for the training data, and avoid such unrealistic predictions. Finally, we provide a proof of concept that holocellulose contents can also be predicted for mineral-rich samples (e.g., peat with mineral admixtures or potentially mineral soils). A key step to improve the models will be to collect training data that are representative for SOM formed under various conditions. This study opens directions to develop operational models to predict SOM holocellulose and Klason lignin contents from mid-infrared spectra.
HOUSING TRANSFORMATION PROCESS IN GOVERNMENT PROVIDED REHABILITATION PROJECT: A STUDY OF BHANDARPARA ASHRAYAN PROKOLPO
Authors: Mallick Puja , Mostafa Anirban 
Published: November 2022

Housing transformation is a commonly practiced phenomenon, especially in government-provided housing all over the world. In Bangladesh as well, the government-provided rehabilitation housing, like Ashrayan projects, experiences transformation of physical elements according to the dwellers’ needs. This physical transformation of housing indicates an existing gap between the housing provision process and users’ needs. These transformations also reflect many unidentified indicators like traditional dwelling patterns, building materials, flexibility, livelihood options, and accommodation of the dwellers’ next generation, etc. that could be helpful to meet the noble vision of Ashrayan projects. A critical understanding of the housing transformation process will help to formulate a more user-centric rehabilitation approach. The aim of this study is to investigate the process of housing transformation and identify decisive indicators causing the transformation in the development and construction phases of government-provided rehabilitation projects. The rehabilitation project of Bhandarpara Ashrayan, in Khulna, a southern district of Bangladesh, was chosen as the case of this study. The project accommodates 260 households in 26 barracks. Among the population, 33 households were chosen as samples for morphological analysis using qualitative techniques. The finding implies that users gradually altered the government-provided housing units. Direct labor, locally available materials, and a self-help approach without the need for building designs or authorizations were well-used indicators in the housing transformation process.