bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimorbidity in patients with low back pain seeking care from Danish chiropractic practice: a cohort study
Authors: Rafn Bolette Skjødt , Hartvigsen Jan , Siersma Volkert , Andersen John Sahl 
Published: September 2022

Abstract
Background:
People with multimorbidity, defined as the co-existence of two or more chronic conditions in an individual, often suffer from pain and functional limitations caused by musculoskeletal disorders and the chronic conditions. In chiropractic practice, two thirds of patients are treated for low back pain (LBP). It is unknown to what extent LBP is accompanied with chronic conditions in chiropractic practice. The objective was to determine the prevalence of multimorbidity among patients with LBP in chiropractric practice and to investigate if multimorbidity affects pain intensity, self-rated health, physical and mental health. Finally, to explore if individuals with multimorbidity have a different recovery for the LBP.
Methods:
Patients presenting with a new episode of LBP were recruited from 10 chiropractic clinics in 2016-18. Patient-reported data concerning socio-demographics, self-rated health, pain intensity, history of LBP, mental health and chronic conditions were collected at baseline. The prevalence of multimorbidity was determined. To evaluate differences in recovery from the LBP, we estimated changes in the Roland Morris Disability Questionnaire (RMDQ) score and use of pain medication at baseline, two weeks, three months and twelve months. The analyses were adjusted using regression models.
Results:
2,083 patients were included at baseline and 71%, 68% and 64% responded to follow-up questionnaires at two weeks, three and twelve months. 1,024 (49%) participants reported to have at least one chronic condition and 421 (20%) had multimorbidity (≥ 2 chronic conditions). The presence of multimorbidity was associated with increased odds of poor self-rated health (OR 2.13), physical fitness (OR 1.79), poor muscular strength (OR 1.52), poor endurance (OR 1.51), and poor balance (OR 1.33). Patients with high LBP intensity combined with multimorbidity showed a poorer recovery than patients without chronic diseases (mean difference in RMDQ score 3.53 at 12 months follow-up). More patients with multimorbidity used pain medication for LBP at 12 months follow-up compared to those without chronic disease (OR 2.36).
Conclusions:
Chiropractors should be aware that patients with LBP may suffer from multimorbidity with poor general health. Patients with multimorbidity also have poorer recovery from LBP than people without chronic disease and clinical follow-up may be indicated.
Microvasculature evaluation of monocular anisometropic amblyopia children by Angio-OCT
Authors: Ye Haiyun , Wang Siying , Zhang Yidan , Fang Wangyi , Ye Han , Chen Luya , Qiao Tong 
Published: September 2022

Abstract
Background
To compare and assess the choroidal and retinal microstructural vascularity in amblyopic eyes with the fellow eyes in monocular anisometropic amblyopic children using angiography optical coherence tomography (Angio-OCT).
Methods
Twenty-seven children (54 eyes; 5.59 ± 1.08 years old; 59.3% girls) were enrolled in this study. Choroidal thickness (CT) was measured with the use of the enhanced depth imaging mode in Angio-OCT. Parafoveal/peripapillary vascular density indices and the foveal avascular zone (FAZ) size were analyzed by Matlab code programming on Angio-OCT images.
Results
The mean FAZ size of the amblyopic eyes were larger both in superficial and deep capillary plexus layer (SCPL/DCPL). Compared with the contralateral eyes (which were emmetropia), all the vascular density indices of SCPL and DCPL in the parafoveal and peripapillary zones were lower in the amblyopic eyes, however, the difference were insignificant (p > 0.05). No significant decrease was observed in four quadrants analyses of the amblyopic eyes (p > 0.05). Except for the measurement at 2000µm and 1500µm from the fovea in temple, CT in amblyopic eyes were significantly thicken than the fellow eyes (p < 0.05).
Conclusion
Compared with the fellow eyes, the CT of certain areas were thicker in the amblyopic eyes. Though the FAZ size of the amblyopic eyes were obvious larger in SCPL/DCPL layers, the retinal vascular density indices in SCPL/DCPL were lower in amblyopia eyes without statistically difference. Angio-OCT may be an effective way to evaluate the status of the choroidal and retinal vascular system in amblyopic children.
Beyond the Gender Binarism: The Neural Correlates of Trans Men Investigated in a Functional Connectivity–Resting State fMRI Study
Authors: Maniaci Giuseppe , Collura Giorgio , Cascia Caterina La , Piccoli Tommaso , Bongiorno Eleonora , Barresi Ilaria , Marrale Maurizio , Gagliardo Cesare , Giammanco Alessandra , Blandino Valeria , Sartorio Crocettarachele , Radellini Stefano , Toia Francesca , Zabbia Giovanni , Bivona Giulia , Midiri Massimo , Ciaccio Marcello , Cordova Adriana , Barbera Daniele La 
Published: September 2022

Abstract
Several studies investigated the specific neural correlates of trans people, highlighting mixed results. This study aimed to investigate the presence of specific functional connectivity in trans men, compared to a homogeneous group of cisgender men and cisgender women. 42 participants (19 trans men, 11 cisgender men, and 12 cisgender women) underwent a resting state fMRI; a blood sample was collected in order to evaluate the hormonal status of testosterone, estradiol, and progesterone. Screening measures were administered for evaluating the intellectual ability and manual preference. Moreover, all participants underwent a neuropsychological evaluation of executive functions, attention, visual-perceptual ability, and verbal fluency. Trans men showed a weaker functional connectivity in the precentral gyrus, subcallosal cortex, paracingulate gyrus, temporal pole, and cingulate gyrus in contrast to cisgender men. Furthermore, trans men showed a worse performance than cisgender men and similar to that of cis women in verbal and visuospatial working-memory. In trans men, functional connectivity of precentral gyrus was positively correlated with blood testosterone and negatively correlated with estradiol and progesterone; the cluster involving the subcallosal cortex showed a positive correlation with testosterone and negative with estradiol, and the functional connectivity from a cluster involving the paracingulate gyrus showed a positive correlation with testosterone. This study sheds light to the importance of overpassing the binary-model, by highlighting the presence of neural pathways that could represent the peculiarity of the neural profile of people with gender dysphoria.
An innovative immunotherapeutic strategy for rheumatoid arthritis: selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1
Authors: Hu Xuanxuan , Li Meiqi , Zhang Yu , Sang Kanru , Zhang Yejun , Li Wulan , Liu Bo , Wan Leyu , Du Bang , Qian Jinheng , Meng Fanxi , Fu Yanneng , Dai Meijuan , Gao Guohui , Ye Hui 
Published: September 2022

Abstract
Background: Thymocyte antigen-1 (THY-1) is a potential therapeutic target for rheumatoid arthritis (RA) treatment, and THY-1 positive fibroblast-like synoviocytes (FLS) are enriched in the synovium of RA patients and participate in angiogenesis to accelerate rheumatoid arthritis development. In this study, we screened a full human antibody targeting THY-1 and exploring its anti-RA activity and mechanism.
Methods: We screened antibody targeting THY-1 (i.e. THY-1 Ab), an antagonistic antibody from human ScFv phage antibody library, by using THY-1 as a target. After proving its binding ability with surface plasmon resonance (SPR), we explored its effect on RA based on FLS transcriptomic analysis and bioinformatics analysis tips treated with THY-1 Ab. Both in vivo and in vitro experiments have proved its effectiveness in the treatment of rheumatoid arthritis. What’s up, we clarified the mechanism of action of the scFv antibody.
Results:THY-1 Ab could not only bind to human THY-1 extracellular domains, but also combine to Murine THY-1. In addition, THY-1 Ab restrained the proliferation and secretion of the proinflammatory factors. THY-1 Ab restrained angiogenesis by inhibiting VEGF expression in RA FLS, and the THY-1 Ab and RA FLS combination can effectively inhibit the differentiation of osteoclasts, which down-regulated the expression of JUNB via hsa_circ_0094342—miRNA-155-5P—SPI1 axis, thus regulating AP-1 to suppress angiogenesis and osteoclast differentiation. In Collagen induced arthritis (CIA), disease progression was effectively alleviated by THY-1 Ab.
Conclusions: These findings support that THY-1 Ab is a potential drug for the rheumatoid arthritis treatment.
Cemented vs. uncemented reverse total shoulder arthroplasty for the primary treatment of proximal humerus fractures in the elderly - A retrospective case-control study
Authors: Kramer Manuel , Olach Martin , Zdravkovic Vilijam , Manser Melanie , Jost Bernhard , Spross Christian 
Published: September 2022

Abstract
Background
Uncemented reverse total shoulder arthroplasty (RTSA) for the primary treatment of proximal humerus fractures (PHF) in elderly patients was introduced at our institution in 2017. Recent reports have raised concerns about increased rates of early bone resorption at the proximal humerus with uncemented fracture stems. The aim of this study was to find out whether there was any difference in functional or radiographic outcomes between cemented and uncemented RTSA for PHF.
Methods
In 2017 and 2018, 17 consecutive patients with uncemented RTSA were included (group nC). We added 34 age and sex matched patients (propensity score matching 1:2) who had undergone cemented RTSA for PHF from 2011–2016 (group C). These two groups were compared in terms of clinical and radiographic outcomes at 2 years after the index surgery.
Results
The mean bone quality was low in both groups: in group nC the deltoid tuberosity index (DTI) was 1.43 (1.22–1.72) and in group C 1.42 (1.22–1.67). At the final 2 year follow-up, the relative CS was 98.3% (71–118) in group nC and 97.9% (36–125) in group C (p = 0.927); the absolute CS was 70.2 (49–89) in group nC and 68.0 (30–94) in group C (p = 0.509). Lucent lines at the humeral site were seen in 8 cases (47%) in group nC and in 13 cases (38%) in group C (p = 0.056). Compared to 3% in group C, all patients in group nC showed at least grade 1 and 65% showed grade 3 bone resorption at the proximal humerus, (p < 0.001).
Conclusion
Compared to cemented RTSA bone resorption at the proximal humerus was significantly more frequent in patients with uncemented RTSA for PHF. So far, this is rather a radiographic than a clinical finding, because both groups showed very successful functional outcomes and low revision rates at the 2 year follow-up.
Level of Evidence III:
a retrospective case-control study
Cost-Benefit Analysis of Building Information Modeling Implementation in Construction Projects: Evidence from Iran
Authors: Azizi Mojtaba , Taheripour Sahar , Faghihi Vahid 
Published: September 2022

Abstract

Construction projects account for a large percentage of national resources, but they are typically finished at a cost and time beyond the initial estimates. Building Information Modeling (BIM) help coordinate and integrate design and construction efforts to achieve the ultimate benefit needed to satisfy all the stakeholders. Despite the reported benefits of BIM, the implementation of such a new technology initially entails costs and barriers that sometimes delay the benefits achieved from their use. BIM also cast suspicion on whether they are useful, thereby reducing its adoption rate. This study aims to evaluate the benefits of implementing BIM functions compared to the cost of its implementation. The results include a Cost-Benefit Analysis (CBA) for three construction projects in Iran by conducting semi-structured interviews. Finally, despite all the limitations and shortcomings, the achieved benefits outweigh the incurred costs, and BIM implementation in these three construction projects was beneficial. One of the innovations of this study is the use of cost-benefit analysis in evaluating the benefits of BIM, which is tangible and quantitative.
Insilico and Invitro Analyses Reveal Promising Antimicrobial Peptides from Myxobacteria
Authors: Arakal Benita S , Whitworth David E , James Philip E. , Rowlands Richard , Madhusoodanan Neethu P T , Baijoo Malvika R , Livingstone Paul G 
Published: September 2022

Abstract
Antimicrobial resistance (AMR) is a global concern, and as soon as new antibiotics are introduced, resistance to those agents emerges. Therefore, there is an increased appetite for alternative antimicrobial agents to traditional antibiotics. Here, we used in silico methods to investigate potential antimicrobial peptides (AMPs) from predatory myxobacteria. 672 potential AMP sequences were extracted from eight complete myxobacterial genomes. Most putative AMPs were predicted to be active against Klebsiella pneumoniae with least activity being predicted against Staphylococcus aureus. 117 AMPs (defined here as ‘potent putative AMPs’) were predicted to have very good activity against more than two bacterial pathogens and these were characterized further in silico. All potent putative AMPs were predicted to have anti-inflammatory and antifungal properties, but none were predicted to be active against viruses. 26 (22%) of them were predicted to be hemolytic to human erythrocytes, five were predicted to have anticancer properties and 56 (47%) were predicted to be biofilm active. Invitro assays using four synthesized AMPs showed promising antibiofilm activities despite high MIC values. 14 putative AMPs had high sequence similarity to proteins which were functionally associated with proteins of known function. The myxobacterial genomes also possessed a variety of biosynthetic gene clusters (BGCs) that can encode antimicrobial secondary metabolites, but their numbers did not correlate with those of the AMPs. We suggest that AMPs from myxobacteria are a promising source of novel antimicrobial agents with a plethora of biological properties.
Photo-Plasmonic Effect as the Hot Electron Generation Mechanism
Authors: Akbari-Moghanjoughi M. 
Published: September 2022

Abstract
Based on the effective Schrödinger-Poisson model a new physical mechanism for resonant hot-electron generation in half-space metal-vacuum configuration of electron gas with arbitrary degree of degeneracy is proposed. The energy dispersion of undamped plasmons in the coupled Hermitian Schrödinger-Poisson system reveals an exceptional point coinciding the minimum energy of plasmon conduction band. Existence of such exceptional behavior is the well-know character of damped oscillation which in this case refers to resonant wave-particle interactions analogous to the collisionless Landau damping effect. The damped Schrödinger-Poisson system is used to model the collective electron tunneling into the vacuum. The damped plasmons is shown to have full-featured exceptional point energy dispersion phase diagram which can have many interesting technological applications. Depending on the tunneling parameter value, in the damped collective excitation band gap there are resonant energy orbital for which the wave-like growing of collective excitations cancels the damping due the quantum electron tunneling. This important feature is solely due to dual-tone wave-particle oscillation characteristics of the collective excitations in the quantum electron gas which leads to the resonant photo-plasmonic effect, as the plasmonic analog of the well-known photo-electric effect. The few nanometer wavelength high energy collective photo-electrons emanating from the typical metal surfaces lead to a much higher efficiency of plasmonic solar cell devices, as compared to their semiconductor counterparts base on electron-hole excitations at the Fermi energy level. The photo-plasmonic effect may be used to study the quantum electron tunneling and electron spill-out at metallic surfaces.
Effective use of the predatory species, Phytoseiulus persimilis and Stethorus punctillum in controlling the two-spotted mite Tetranychus urticae in croton greenhouse
Authors: Adly D. 
Published: September 2022

Abstract
The croton, Codiaeum variegatum is a beautiful tropical plant. The two-spotted mite, Tetranychus urticae Koch, causes economic damage to the croton. The present study aimed to control T. urticae by releasing two predatory species, Phytoseiulus persimilis Athias Henriot and Stethorus punctillum Weise, depending on the suitable temperature and humidity of each predator. The experiments were carried out at commercial plastic greenhouses for two seasons. Once the mite T. urticae infestation was detected, the predators were released. The predator, P. persimilis was released three times, with a rate of 9/m2. It increased when the temperature and humidity ranged from 25.5–29°C and 72.8–86.4% RH, respectively, while it disappeared when the temperature increased above 30°C. There was a negative correlation between P. persimilis and temperature, but a positive correlation with relative humidity. The predator, S. punctillum, was released twice, at a rate of 0.5/m2. It increased when the temperature and humidity ranged from 31.8–35°C and 65–77% RH, respectively. There was a positive correlation between S. punctillum and temperature, but a negative correlation with relative humidity. In the two seasons, the population numbers of the mite T. urticae decreased gradually to nil/cm2/croton leaf in the biological greenhouse. In the control greenhouse, the population of T. urticae increased to 59.47 ± 6.34 and 85.63 ± 10.45/cm2/croton leaf in 2019 and 2020, respectively, at the end of the season. Integration of the two predators, P. persimilis and S. punctillum was able to achieve effective control of T. urticae when used according to the suitable temperature for each predator in croton greenhouses.
MST1 is downregulated and acts as a tumor suppressor in prostate cancer
Authors: Huang Yuhang , Li Yuqing , Yin Shiyuan , Fang Linna , Zhong Kun , Ma Wei , Tong Zhuting , Cai Yongping , Yin Yu 
Published: September 2022

Abstract
Tumor suppressive properties have been identified in the mammalian sterile cell line, 20 like kinase-1 (MST-1) and the role they may have in prostate cancer (PCa) has yet to be elucidated due to the paucity of reports. The goal of this study is to investigate the expression and the potential role of MST1 in the development and progression of PCa.
The expression level of MST1 in PCa was analyzed by immunohistochemistry (IHC), qPCR and western blotting, and the clinicopathological parameters of PCa patients underwent statistical analysis. MST1, vascular endothelial growth factor (VEGF), androgen receptor (AR), and neuron-specific enolase (NSE) proteins were analyzed by western blot. A cell counting kit, CCK-8 assay and a transwell migration assay were used to assess the proliferation and migration capacity of C4-2 cells. Human umbilical vein endothelial cells, (HUVECs) were used in a tubule formation assay to evaluate prostate cancer angiogenesis.
The results of this study documents that the expression level of MST1 is downregulated in PCa and the downregulation closely correlates with the metastatic status of patients. (p < 0.05). Overexpression of MST1 significantly inhibits C4-2 cells' proliferation and migration. In addition, overexpression of MST1 significantly inhibits VEGF, AR, NSE expression, and the angiogenesis of PCa. This study suggests that MST1 downregulation may play a role as a tumor suppressor gene in the pathogenesis and progression of prostate cancer. MST1 downregulation also inhibits the neuroendocrine differentiation and the angiogenesis of early-stage prostate cancer cells.
Results on certain biopolymers using M-polynomial and NM-polynomial of topological indices
Authors: Yasin Mohammed , M Suresh 
Published: September 2022

Abstract
The topological indices is a numerical descriptors that helps in forecasting the physio-chemical characteristics and biological actions of a chemical molecules. It is often helpful forecast numerous physiochemical attributes and biological actions of molecules in chemometrices, bioinformatics and biomedicines. In the present work establish the M-polynommial and NM-polynomial of some utmost familiar biopolymers (xanthan gum, gellan gum and polyacrylamide). These polynomials are used to extract certain degree-based TI’s. The uses of these biopolymers, which can increasingly take the place of traditional admixtures for the application of soil stability and enhancement.
Mathematics Subject Classification 05C92 . 05C09 . 92E10
Strength Properties, Thermal Stability, and Microstructure of Acetylated Obeche (Triplochiton Scleroxylon K. Schum) Wood
Authors: Adebawo Funke Grace , Yekeen Ogunsanwo Olukayode , Adegoke Olaoluwa Adeniyi , Lucian Lucia 
Published: September 2022

Abstract
Acetylation is a well-established process to improve dimensional properties of wood and resistance to fungi attack. This study was carried out due to limited studies on its effect on mechanical properties, thermal stability, and microstructural aspects of wood. Wood blocks, (each 20×20×60 mm) of Obeche were acetylated with acetic anhydride at 120°C for 60, 120, 180, 240 and 300 minutes. The microstructure and thermal stability of acetylated and unmodified wood blocks were assessed using SEM and TGA, respectively. The Maximum compressive strength (MCS//g) and Modulus of Elasticity (MOE) of the wood specimens were also determined. The SEM indicated no visible damage or defect in the microstructure of all the acetylated wood and no significant differences in the strength properties compared to untreated wood. Acetylated wood showed an increased thermal stability compared to unmodified wood.
Do screens make us anxious? Associations between screen-time, physical activity, and anxiety among adolescents
Authors: Forte Chloe , O’Sullivan Darragh , McDowell Cillian P. , Hallgren Mats , Woods Catherine B. , Herring Matthew P. 
Published: September 2022

Abstract

Purpose: The associations of screen-time (ST) and physical activity (PA) with adolescent mental health are largely well-established. However, there is limited and inconsistent evidence for the ST, PA, and anxiety relationship.
Methods: We cross-sectionally examined associations between anxiety symptoms with various ST modes and PA levels. Participants (n=1756, n=995 female) living in the Republic of Ireland completed self-report questionnaires assessing individual ST modes (watching TV, using a computer for fun and using a smartphone), PA levels (low, moderate, and high) and anxiety symptoms were measured by the State-Trait Anxiety Inventory. Multiple linear regressions investigated associations between ST modes and anxiety symptoms while controlling for covariates. We stratified the sample according to PA level and gender to assess their impact on the ST-anxiety relationship.
Results: Computer (β=0.094 p≤0.001) and phone use (β=0.084, p≤0.002) were associated with higher anxiety symptoms. TV viewing was not associated with anxiety symptoms. PA level appeared to moderate the association between phone use and anxiety symptoms, such that those with higher PA levels had no observable associations between phone use and anxiety symptoms. No moderating effect was observed for computer use in the full sample or for males but was observed in females.
Conclusions: These differential findings highlight the complex nature of these associations among adolescents. Prospective studies of the relationship between screen-time and physical activity with anxiety are needed.