bluuebunny/crossref_metadata_2025_split huggingface dataset:
DVRSF: A Deep Reinforcement Learning Method Based on Dynamic Velocity Reward &amp; Stagnation Fine
Authors: Zhang Qiyang , Chen Xiliang , Li Qingwei 
Published: October 2022

Abstract
When dealing with the difficult exploration problems caused by sparse rewards, pre-designed environment reward leads to poor performance of most RL algorithms. The existing algorithms fail to resolve the contradiction between the difficulty exploration and exploration efficiency. In this situation, it is necessary to design rewards more carefully, make more accurate judgments and feedback on the exploration status of agents. Therefore, we designed a RL exploration method based on trajectory entropy, and extracted two features during the training process to participate in the construction of internal rewards. On this basis, we add a monitoring method based on exploration speed to improve the over divergence problem in the agent exploration process. This method constructs a potential feature based on exploration speed according to the information sampling obtained in real time during training, gives real-time feedback to the agent, and dynamically adds it to the reward of each MDP. These two methods are called stagnation fine and velocity reward. Stagnation fine is intended to encourage the agent to get out of the dilemma as soon as possible when the agent is falling in. Velocity reward is used to improve the agent's exploration speed in the right direction and improve the over divergence of exploration. The algorithm has good generality, can avoid the influence of network structure in different algorithms, and can be easily added to existing RL algorithms, such as A3C and PPO. We evaluated our approach in different types of environments in Super Mario Bros. The experimental results show that the learning speed and accuracy of agents using DVRSF are significantly better than those of baseline such as PPO and A3C in most test tasks.
Three-Dimensional Hierarchical Porous Carbon with High Oxygen Content from Bitumite Mixed with Waste Powder Char for Excellent Wastewater Purification
Authors: Yin Yufeng , Zhao Yiting , Wang Jing 
Published: October 2022

Abstract
Waste powder char (WPC) is harmful to the environment and is abundant in the production process of the coal chemical industry, which will produce relatively low heat energy and release large amounts of coal ash if it is burned directly. To efficiently solve this issue and create high values, three-dimensional hierarchical porous carbons (HPCs) with abundant oxygen-containing groups were prepared by collaborative pyrolysis carbonization and steam activation from Yulin bitumite (YL) mixed with WPC. The effects of preparation parameters including WPC doping amount, activation temperature, and activation time on pore structure development and adsorption capacity of methylene blue from wastewater were explored in detail. The obtained HPCs are micropores structure combined with mesopores and the largest specific surface area (SSA) is reached to 1299.75 m2g− 1 (8-YLHPC-950-3). Furthermore, 8-YLHPC-900-3 presents a high oxygen content reaches 15.92wt%. And the SSA and total pore volume of HPC with an 8wt% WPC doping ratio are larger than that without WPC doping. Meanwhile, HPCs show the superior adsorption performance of methylene blue in aqueous solution, especially when the HPC was prepared at the activation temperature of 900 ℃, steam flow of 0.8 mLg− 1h− 1, and activation time of 3 h. It presents the optimal adsorption capacity that is 301 mgg− 1 of methylene blue adsorption value (MBV). We conclude a value-added utilization approach for coal based solid waste and a potential feedstock for adsorption material used in the purification of wastewater. The results achieved in this study provide a green and environmentally friendly method for the preparation of HPCs from waste powder char which is not only an industrial reference for the removal of methylene blue from wastewater by HPCs but also contributes to the sustainable development of the coal chemical industry.
Panitumumab plus trifluridine/tipiracil as anti-Epidermal Growth Factor Receptor rechallenge therapy in chemo-refractory RAS wild-type metastatic colorectal cancer: the randomized phase 2 VELO trial
Authors: Ciardiello Fortunato , Troiani Teresa , Napolitano Stefania , De Falco Vincenzo , Martini Giulia , Ciardiello Davide , Martinelli Erika , Corte Carminia Maria Della , Esposito Lucia , Famiglietti Vincenzo , Liello Alessandra Di , Avallone Antonio , Cardone Claudia , De Stefano Alfonso , Montesarchio Vincenzo , Zampino Maria Giulia , Bordonaro Roberto , Scartozzi Mario , Santini Daniele , Maio Massimo Di , De Vita Ferdinando , Altucci Lucia , Marrone Francesca 
Published: October 2022

Abstract
Current therapies for chemo-refractory metastatic colorectal cancer (mCRC) have limited efficacy. Rechallenge with epidermal growth factor receptor (EGFR) inhibitors in RAS wild-type (WT) mCRC could be valuable in this setting. In VELO, a randomized two-arm phase 2 trial, anti-EGFR monoclonal antibody panitumumab plus standard-of-care trifluridine/tipiracil (31 patients, arm B) was compared to trifluridine/tipiracil (31 patients, arm A) as third-line therapy (ClinicalTrials.gov Identifier NCT05468892). Primary endpoint, progression-free survival (PFS), was met. Median PFS was 4.0 months in arm B versus 2.5 months in arm A [hazard ratio (HR): 0.48; 95% CI 0.28–0.82; P = 0.007]. Baseline plasma RAS/BRAF WT circulating tumor DNA identified patients obtaining prolonged clinical benefit with panitumumab plus trifluridine/tipiracil as compared to trifluridine/tipiracil with PFS rates at 6 months of 38.5% versus 13% and at 12 months of 15.4% versus 0%, respectively. These findings warrant further development for liquid biopsy-guided anti-EGFR rechallenge combination strategies in chemo-refractory RAS WT mCRC.
Prevotella copri exhausts host’s intrinsic indol-3-pyruvid acid to promote breast cancer development: Inactivation of AMPK via UHRF1-mediated negative regulation
Authors: Su Jiyan , Lin Xiaojie , Li Dan , Yang Chunmin , Lv Shumei , Chen Xiaohong , Yang Xiujuan , Pan Botao , Xu Rui , Ren Liping , Zhang Yanfang , Xie Yizhen , Chen Qianjun , Xia Chenglai 
Published: October 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
The effects and clinical outcomes of inflammation-related factors in the middle and upper calyceal renal calculi without ureteral stent after flexible ureterorenoscopy
Authors: Wang Shiping , Li Guikang , Wang Ruihan , Cui Yanxiu , Wang Pu , Yang Bin 
Published: October 2022

Abstract
Objective
To investigate the inflammatory factors and clinical outcomes of the middle and upper calyceal renal calculi after flexible ureterorenoscopy without the usage of the ureteral stent.
Data and Methods:
150 patients were randomly divided into three groups: Group A, Group B and Group C. In Group A, double-J stent was implanted preoperatively, but not postoperatively. In Group C, Double-J stent was implanted postoperatively, but not preoperatively. In Group B, double-J stent were implanted preoperatively and postoperatively. Finally, the inflammatory factors and clinical effects of the 3 groups were compared.
Results
There is a significant difference in operation time among the 3 groups with group A having the shortest time (P < 0.05). There have been no significant differences in stone clearance rate (P > 0.05). Additionally, it is observed that the incidence of postoperative hematuria and bladder irritation in group A has been comparatively lower than those in groups B and C (P < 0.01). At 24 hours after the operation among the 3 groups, and the incidence of fever between groups A and B observed has been considerably lower than that of group C (P < 0.05). Lastly, CRP and WBC in group A and B were lower than those in group C after operation(P < 0.05).
Conclusion
For the patients with middle and upper calyceal renal calculi, by prepositioning double-J stent before the operation along with the absence of ureteral stent after the flexible ureterorenoscopy, it has been presented that the operation time can be effectively reduced. At the same time, it will not affect the postoperative clearance rate, significantly reduce the incidence of postoperative complications, and will also not increase the postoperative-related inflammatory factors.
Histological study on the skin structure in two mudskippers, Periophthalmus waltoni and Boleophthalmus dussumieri in relation to their terrestrial life ​
Authors: Dorostghoal Mehran , Jazayeri Ashraf , Ashiri Sara 
Published: October 2022

Abstract
Microscopic structure of skin in two amphibious mudskipper fish; Boleophthalmus dussumieri Valenciennes, 1837 (B. dussumeri) and Periophthalmus waltoni Koumans, 1941 (P. waltoni) were investigated in relation to their lifestyle. The general structure of skin is the same among the two species. Epidermis in B. dussumeri was thicker significantly than P. waltoni. The dermal bulges were only well developed in the skin of B. dussumeri. Mucous cells were absent in the epidermis of P. waltoni but present in B. dussumeri. Both B. dussumeri and P. waltoni have well-developed swollen middle cells as a shared epidermal feature. The thickness of the middle cell layer of the epidermis in B. dussumeri was significantly greater than in P. waltoni. Capillaries in the dorsal and ventral parts of the body are more closely distributed to the epidermal surface in P. waltoni than in B. dussumeri. The diffusion distance in the dorsal epidermis of P. waltoni was less than that in the ventral epidermis of B. dussumeri. A comparative examination of the skin of mudskipper species suggests that, due to the more terrestrial lifestyle adopted by P. waltoni, the skin contributes more to respiration.
Thermodynamic Properties and Persistent Currents of Harmonic Oscillator Under AB-Flux Field in Point-like Defect with Inverse Square Potential
Authors: Ahmed Faizuddin 
Published: October 2022

Abstract
In this analysis, we study the eigenvalue solution of non-relativistic particles confined by the Aharonov-Bohm (AB) flux field with pseudoharmonic potential (harmonic oscillator plus inverse square potential) in a point-like global monopole defect. We then study the thermodynamic properties of harmonic oscillator, such as the vibrational free energy, mean energy, entropy, and specific heat capacity using the partition function Z(β) and analyze the influences of the topological defects and the magnetic flux field with this potential. Finally, an expression of persistent currents is obtained and analyze the effects of the topological defects and the potential.
Creation of the initial breeding material of soft winter wheat with a complex of economically valuable traits
Authors: Murashko L. A. , Mukha T. I. , Humenyuk O. V. , Suddenko Yu. M. , Novytska N. V. , Martynov O. M. 
Published: October 2022

Purpose. Creation of new breeding material of soft winter wheat, highly resistant to diseases of the ear and pest colonization for use in the breeding process.
Methods. The studies were carried out in 2017–2020 under conditions of artificial inoculation of wheat plants with pathogens of common bunt and fusariosis of the ear in field infectious nurseries of the Department of Plant Protection of the V. M. Remeslo Institute of Wheat of NAAS. An artificial infectious background of common bunt was created according to the method of A. I. Borggard-Anpilogov, which consists in contamination of seed material with spores several days before sowing. An artificial infectious background of fusarium ear blight was created by spraying soft winter wheat plants in the flowering phase with a suspension of spores isolated from the local pathogen population.
Results. According to the results of the conducted research, highly resistant (up to 5% ear dama­ge) combinations of hybrids of the fourth generation of soft wheat were selected against the causative agent of fusarium: ‘Berehynia Myronivska’ / ‘Nobeoka bozu’ had a thrips population of 5.2 ind./ear, and cereal leaf beetle – 35,0 ind./m2 and ‘Horly­tsia myronivska’ / ‘C-Lokia’, the thrips population of which was 5.0 ind./ear, cereal leaf beetle – 2.0 ind./m2. On an artificial infectious background of fourth-generation hybrids, in terms of resistance to common bunt, the crossing combinations ‘Berehynia Myronivska’ / ‘Horianka’, ‘Lehenda Myronivska’ / ‘Nana’ were selected, which were affected by common bunt from 15 to 20%, and thrips population was 2.8–8.6 ind./ear, cereal leaf beetle – 5.0–6.0 ind./m2. The highest indicators of the length of the ear, the number of grains in the ear and the mass of grain from the ear were obtained in the combinations of ‘Oberih Myronivskyi’ / ‘Maris Templer’ and ‘Berehynia Myronivska’ / ‘Horianka’, which were created in accordance with the breeding programs of soft winter wheat for resistance against fusarium head blight and common bunt.
Conclusions. The constant lines of soft winter wheat, isolated by complex resistance against diseases and pests, are used in the breeding process of the V. M. Remeslo Institute of Wheat of NAAS and the National Center of Plant Genetic Resources of Ukraine (The Plant Production Institute named after V. Ya. Yuriev, Kharkiv).
Flavonoids for the Treatment of Breast Cancer, Present Status and Future Prospective
Authors: Sahoo Sanjeeb Kumar , Sahoo Sonali , Mohapatra Priyanka 
Published: October 2022

Abstract:
Breast Cancer is one of the most notorious cancer affecting women globally. Current therapies available for
breast cancer treatment have certain limited efficacy; develop drug resistance and severe adverse effects. Thus, identifying
novel therapies for treatment will reduce the devastating effect on cancer survivors. The exhilarating and fastgrowing
studies on flavonoids have evidenced that it has the potential to inflect various antitumor activity and modulate
various signal transduction pathways in carcinogenesis. Flavonoids also have been found to regulate cellular metabolism
and oxidative stress, cell cycle progression, angiogenesis and metastasis, ultimately preventing the progression
of the diseases. As per the reports, a flavonoid-rich diet appears to be the most potent and promising approach to
abate the risk of cancer. Thus, now a day, these are the prime target for drug discovery research. Based on existing
findings, it can be concluded that beyond the currently employed chemotherapeutics, natural products (like flavonoids)
exhibit pleiotropic, multi-target activities and are budding as possible complementary chemopreventive molecules
against breast cancer with fewer side effects than conventional therapy. In this review, we comprehensively highlight
an outline of the multiple pleiotropic pharmacological effects of various major classes of flavonoids on breast cancer
with their specific mechanisms underlying its anticancer effect.
An Efficient Power Management Strategy of a Solar Powered Smart
Camera-road Side Unit Integrated Platform
Authors: Ibrahim Qutaiba 
Published: October 2022

Background:
This paper proposes efficient employment of a self-powered VANET infrastructure.
Miscellaneous techniques and algorithms are suggested to help the realization of such a
framework.

Objective:
The current work attempts to enhance the network architecture of the Green VANET by
adopting the self-powered fog computing concept for better networking, computing, and storage performance.

Method:
The green fog layer consists of three components: a self-powered edge server, Wireless Solar
Routers (WSRs), and a new device resulting from the integration between a solar-powered Smart
Camera (SC) and a solar-powered Road Side Unit (RSU) in order to create a better sensing mechanism
of the road traffic.

Result:
A proper power management strategy is suggested and installed locally in the self-powered
devices to decrease their power utilization by 80% and lengthen their batteries' lifetime from 17 to 64
hours.

Conclusion:
The different methods and algorithms suggested in this paper are realized and tested using
an experimental framework based on a mix of evaluation kits. It is noticed that the suggested
power management algorithm can adjust the duty cycling according to the accessible energy levels,
and thus, the SC-RSU nodes and the WSRs keep on working in a pre-managed and arranged manner.
Mailed Letter Versus Phone Call to Increase Diabetic-Related Retinopathy Screening Engagement by Patients in a Team-Based Primary Care Practice: Prospective, Single-Masked, Randomized Trial
Authors: Stamenova Vess , Nguyen Megan , Onabajo Nike , Merritt Rebecca , Sutakovic Olivera , Mossman Kathryn , Wong Ivy , Ives-Baine Lori , Bhatia R Sacha , Brent Michael H , Bhattacharyya Onil 
Published: October 2022

Background
Vision loss from diabetic-related retinopathy (DR) is preventable through regular screening.

Objective
The purpose of this study was to test different patient engagement approaches to expand a teleophthalmology program at a primary care clinic in the city of Toronto, Canada.

Methods
A teleophthalmology program was set up in a large, urban, academic, team-based primary care practice. Patients older than 18 years with type 1 or type 2 diabetes were randomized to one of the following 4 engagement strategies: phone call, mail, mail plus phone call, or usual care. Outreach was conducted by administrative staff within the clinic. The primary outcome was booking an appointment for DR screening.

Results
A total of 23 patients in the phone, 28 in the mail, 32 in the mail plus phone call, and 27 in the control (usual care) group were included in the analysis. After the intervention and after excluding patients who said they were screened, 88% (15/17) of patients in the phone, 11% (2/18) in the mail, and 100% (21/21) in the mail and phone group booked an appointment with the teleophthalmology program compared to 0% (0/12) in the control group. Phoning patients positively predicted patients booking a teleophthalmology appointment (P<.001), whereas mailing a letter had no effect.

Conclusions
Patient engagement to book DR screening via teleophthalmology in an urban, academic, team-based primary care practice using telephone calls was much more effective than patient engagement using letters or usual care. Practices that have access to a local DR screening program and have resources for such engagement strategies should consider using them as a means to improve their DR screening rates.

Trial Registration
ClinicalTrials.gov NCT03927859; https://clinicaltrials.gov/ct2/show/NCT03927859
Views, Use, and Experiences of Web-Based Access to Pediatric Electronic Health Records for Children, Adolescents, and Parents: Scoping Review
Authors: Hagström Josefin , Blease Charlotte , Haage Barbara , Scandurra Isabella , Hansson Scharlett , Hägglund Maria 
Published: October 2022

Background
Ongoing efforts worldwide to provide patients with patient-accessible electronic health records (PAEHRs) have led to variability in adolescent and parental access across providers, regions, and countries. There is no compilation of evidence to guide policy decisions in matters such as access age and the extent of parent proxy access. In this paper, we outline our scoping review of different stakeholders’ (including but not limited to end users) views, use, and experiences pertaining to web-based access to electronic health records (EHRs) by children, adolescents, and parents.

Objective
The aim of this study was to identify, categorize, and summarize knowledge about different stakeholders’ (eg, children and adolescents, parents, health care professionals [HCPs], policy makers, and designers of patient portals or PAEHRs) views, use, and experiences of EHR access for children, adolescents, and parents.

Methods
A scoping review was conducted according to the Arksey and O’Malley framework. A literature search identified eligible papers that focused on EHR access for children, adolescents, and parents that were published between 2007 and 2021. A number of databases were used to search for literature (PubMed, CINAHL, and PsycINFO).

Results
The approach resulted in 4817 identified articles and 74 (1.54%) included articles. The papers were predominantly viewpoints based in the United States, and the number of studies on parents was larger than that on adolescents and HCPs combined. First, adolescents and parents without access anticipated low literacy and confidentiality issues; however, adolescents and parents who had accessed their records did not report such concerns. Second, the main issue for HCPs was maintaining adolescent confidentiality. This remained an issue after using PAEHRs for parents, HCPs, and other stakeholders but was not an experienced issue for adolescents. Third, the viewpoints of other stakeholders provided a number of suggestions to mitigate issues. Finally, education is needed for adolescents, parents, and HCPs.

Conclusions
There is limited research on pediatric PAEHRs, particularly outside the United States, and on adolescents’ experiences with web-based access to their records. These findings could inform the design and implementation of future regulations regarding access to PAEHRs. Further examination is warranted on the experiences of adolescents, parents, and HCPs to improve usability and utility, inform universal principles reducing the current arbitrariness in the child’s age for own and parental access to EHRs among providers worldwide, and ensure that portals are equipped to safely and appropriately manage a wide variety of patient circumstances.

International Registered Report Identifier (IRRID)
RR2-10.2196/36158
Cuidado à mulher no climatério participação da família e estudantes de enfermagem
Authors: Silva dos Anjos Ana Paula , Meira Oliveira Zulmerinda , Prina Rocha Iago , Mesquita Mendes Pires Vilara Maria , Santana dos Santos Ana Dulce 
Published: October 2022

Este estudo objetiva identificar a concepção de climatério para mulheres que o vivenciam bem como o papel de familiares e estudantes no cuidado a essas mulheres. Estudo qualitativo, descritivo, desenvolvido em unidade básica de saúde. As participantes foram17 mulheres com mais de 40 anos que frequentaram o serviço de preventivo. Os dados foram coletados por meio da entrevista semiestruturada após a aprovação pelo Comitê de Ética em Pesquisa (CEP) da Universidade Estadual do Sudoeste da Bahia, sob protocolo de nº 2.440.117. Os dados obtidos foram tratados pela técnica de Análise Temática de Conteúdo de Bardin. Resultados abordam características sociodemográficas das participantes, e duas categorias temáticas: Desconhecendo o climatério; e Família, redes sociais e estudantes como estratégia de cuidado à mulher no climatério. Na primeira, as mulheres desconhecem o climatério e atrelam esta fase à menopausa, e na segunda, elas reconhecem que a família, estudantes e redes sociais são fortes aliados à terapêutica nessa fase da vida. Constatou-se um déficit de conhecimento das participantes sobre o climatério, além de mostrar a influência das redes sociais, familiares e estudantes de enfermagem, e a própria universidade como fontes de estratégias terapêuticas à mulher que vivencia o climatério