bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of lipid profile with severity of hepatitis B virus related chronic liver disease in adult
Authors: Islam Md Asiful , Hasan Hamid , Yasmin Gulnar , Rahman Minhaj Rashidur , Miah Md Titu 
Published: July 2022

Background: Chronic liver disease (CLD) is a major health problem and contributes to a common cause of hepatocellular carcinoma, disability and death worldwide. Hepatitis B virus (HBV) is the leading cause of CLD in our country. Abnormal lipid profile is expected in those with severe liver dysfunction.
Objective: The objective of the study was to determine the alteration of lipid profile (total cholesterol, triglyceride, LDL-C and HDL-C) in HBV positive adult CLD patients and to correlate with severity of liver damage.
Methods: This case control study was conducted for one year between January 2018 to December 2018. One hundred and three patients, >18 years old, admitted with HBV positive CLD in Dhaka Medical College Hospital were recorded as case and 103 age and sex matched, healthy population, were recorded as control. A standard case record form including demographics, histories, clinical examinations and different investigations were completed for each group. Then lipid profile values of cases were compared to controls and different Child-Pugh and MELD scores, were used to see severity of liver damage in CLD patients.
Results: In patients with HBV positive adult CLD, there were a significant decrease in serum total cholesterol. LDL-C and HDL-C levels compared to the control group (mean 131.4 vs 179.3, 72.5 vs 109.6, and 31.0 vs 40.4 mg/dl, respectively; p<0.001). Comparison of lipid profile with pathologic progression of CLD revealed that these values were diminished gradually with progression of liver damage. Overall triglyceride level was decreased marginally in cases when compared to controls (mean 139.2 vs 146.6 and p=0.047) and this reduction was observed in only advanced stage.
Conclusion: Serum total cholesterol, LDL-C and HDL-C level in HBV positive CLD patients were low and diminished gradually with severity of liver damage. Triglyceride level was marginally significant and diminished in advanced CLD.
Bang Med J Khulna 2021; 54 : 08-12
PENENTUAN OPERATOR PACKER DAN LOADER YANG OPTIMAL DENGAN METODE WORK SAMPLING DAN WORK LOAD ANALYSIS (Studi Kasus : PT. Semen Indonesia Tbk. Plant Gresik)
Authors: Bashori Shiddiq Adhim , Mahbubah Nina Aini 
Published: July 2022

PT Semen Indonesia Plant Gresik merupakan pabrik manufaktur yang memproduksi semen di kabupaten Gresik. Pada tahun 2019, bahan baku yang diproduksi 50% sudah dilakukan proses pengolahan dari Tuban yang dikirim dalam bentuk klinker. Permasalahan yang teridentifikasi yaitu Pertama, sejak PT Semen Gresik (Persero) Tbk bertransformasi menjadi PT Semen Indonesia (Persero) Tbk, dan berperan sebagai strategic holding company membuat PT. Semen Gresik yang sebelumnya dalam memproduksi produk semen secara terus menerus, akan tetapi pada saat ini tahun 2019 aktivitas strategi proses produksi yang diterapkan oleh perusahaan adalah berubah dengan sistem Make To Order (MTO). Kedua, banyaknya waktu menganggur pada operator packer dan loader. Ketiga, tidak tercapainya jumlah nilai release yang direncanakan oleh perusahaan dengan hasil release yang sudah tercpai saat ini. Tujuan penelitian ini yaitu menganalisis beban kerja yang diperlukan untuk digunakan sebagai dasar dalam alternatif penentuan kebutuhan jumlah tenaga kerja yang optimal dengan metode Work Sampling Dan Work Load Analysis. Dari hasil perhitungan metode work sampling berdasarkan data sampling kerja random dan sampling kerja random dengan rumus excel, jumlah tenaga kerja yang dibutuhkan operator packer dan operator loader berdasarkan hasil waktu standar yaitu sama-sama membutuhkan 1 orang. sedangkan hasil dari metode work load analysis berdasarkan data sampling kerja random mampu memberikan alternatif 7 operator packer per shift. Untuk alternatif jumlah operator loader sebanyak 9 operator loader per shift. Sedangkan berdasarkan perhitungan data sampling kerja random dengan rumus excel mampu memberikan alternatif 5 operator packer per shift. Untuk alternatif jumlah operator loader sebanyak 6 operator loader per shift.
PENERAPAN LINE BALANCING UNTUK MENGURANGI WAKTU MENUNGGU PADA PROSES LEAK TEST VALVE (Studi kasus di PT.Tomoe Valve Batam)
Authors: Manurung Erikson , Arifin Zaenal , Merjani Abdullah 
Published: July 2022

Skripsi ini dilatarbelakangi oleh meningkatnya permintaan terhadap produk valve di PT.Tomoe Valve Batam, menuntut untuk melakukan peningkatan hasil produksi dari 2400 unit/minggu menjadi 3500 unit/minggu, kenaikan permintaan sebesar 46 % dari kapasitas sekarang. Dengan mengarahkan sumber daya organisasi untuk melakukan efisiensi produktifitas sehingga menghasilkan output yang diharapkan, dalam peningkatan produktivitas dalam memenuhi permintaan tersebut, sebagai upaya menghadapi permintaan tersebut berbagai usaha ditempuh oleh PT.Tomoe Valve Batam, salah satunya adalah mengurangi waktu tunggu pada proses leak test. Untuk mendukung tujuan tersebut maka penulis ingin melakukan penelitian tentang “Penerapan Line Balancing untuk dapat digunakan sebagai faktor pendorong peningkatan produktivitas, dengan mempertimbangkan berbagai variable yang mempengaruhi produktifitas yang bervariasi antara input dan output dan setiap aspek yang memiliki efek secara signifikan mempengaruhi produktivitas pada sebuah proses karena perancangan ulang merupakan suatu upaya yang sangat cepat untuk melakukan perubahan dalam mengoptimalkan flow proses kerja dan produktivitas didalam suatu proses produksi. Sebagai identifikasi masalah penelitian ini adalah sebagai berikut: 1) Seberapa besar efek waktu terbuang karena menunggu pada proses leak test valve terhadap output ? 2) Hal apa saja yang mempengaruhi waktu menunggu pada proses leak test valve ?Metode yang digunakan adalah metode Rank Positional Wight ( RPW ). Sumber data dalam penelitian ini adalah PT.Tomoe Valve Batam. Pendekatan yang digunakan adalah trial dan error. Bahan penelitian adalah Cycle Time. Data dalam penelitian ini adalah data primer dan data sekunder. Teknik pengumpulan data adalah penelitian lapangan dan studi literatur. Alat pengumpul data utama dalam penelitian ini adalah stopwatch dalam tiga metode yaitu Continious Timing ( Pengukuran yang berlanjut terus), Repetitive/Snapback Timing ( Pengukuran yang berulang ) dan Accumulative Timing ( Pengukuran Akumulatif ). Data yang dikumpulkan adalah gambar produk, peta line produksi, proses produksi, operation proses chart (OPC), proses flow chart (PFC) pada proses produksi valve serta kapasitas produksi dan data permintaan di PT. Tomoe Valve Batam.Berdasarkan hasil penelitian terhadap Penerapan line balancing untuk mengurangi waktu tunggu pada proses leak test di PT.Tomoe Valve Batam, ditemukan beberapa hal tentang penerapan line balancing yaitu Upaya penerapan line balancing untuk mengurangi waktu tunggu didapatkan waktu siklus sebelum perbaikan sebesar 1.0 menit/unit = 60 unit/jam dan berdasarkan penerapan metode line balancing dengan penambahan 1 cell pada proses sub-assembly didapatkan sebesar 120 unit/jam. Jadi output yang hilang karena menunggu pada proses leak test = 60 unit/jam dan tindakan perbaikan yang dilakukan agar waktu menunggu pada proses leak test menurun adalah dengan penambahan 1 cell pada proses sub-assembly.
The costs incurred by patients to get eligibility to PCSK9 treatment and one-year follow-up: the results of the PRIOR Study
Authors: Bertolani Arianna , Ravasio Roberto , Raimondo Paola , Jommi Claudio 
Published: July 2022

Background. Several health care services are required to get eligibility to PCSK9-inhibitors medicines and the follow-up of patients being treated. The ultimate goal is making prescriptions appropriate and monitoring the effects of these drugs. Some recent papers (opinion / consensus documents) highlighted the necessity to make simpler this clinical pathway. Our paper illustrates the cost of this pathway incurred by patients (direct healthcare and non-healthcare costs, productivity losses by patients and their possible care-giver due to the time dedicated to healthcare services).
Methods. The study relied on a retrospective data collection through a structured questionnaire administered to 240 patients, being on treatments with PCSK9-inhibiotrd drugs for at least one year. Patients were recruited in 4 Italian healthcare centres from June 2020 to July 2021.
Results. Recruited patients are 64 years old on average. 64% of patients are males and 36% are actively employed and working. Mean cost incurred by patients amounts to € 926,1. Direct healthcare costs, direct non-healthcare costs and productivity losses equal to € 463,5 (50%), € 136,7 (15%) and € 325,9 (35%) respectively. Healthcare services fully covered by the National Health Service account for 56% of the total. Co-payments are applied to 26% of healthcare services, whereas patients pay the full price for 18% healthcare services.
Discussion. Getting eligibility to PCSK9-inhibitors and managing patients’ follow-up generate important costs incurred by patients. Furthermore, these costs are very different across healthcare centres. We are fully aware that appropriateness of prescriptions and patients’ follow-up are very important. However, simplifying the clinical pathway would bring economic advantages and could make more homogenous the way this pathway is managed by healthcare centres.
DECISION SUPPORT SYSTEM TO DETERMINE THE BEST ONLINE SHOP COLLEGE STUDENTS USING THE TOPSIS METHOD
Authors: Marlina Marlina , Sari Retno 
Published: July 2022

Internet users in Indonesia aged 16 to 64 years who access the internet on mobile phones as many as 195.3 million. In 2015 the number of online shops was 7.4 million people. Convenience and customer service today are key in improving an online shop. The number of online shop applications available for MSME has difficulty in determining the online shop to determine the right online shop in marketing products among students. The TOPSIS method is used as a method for decision-making because it has a simple and easy-to-understand the concept. This study has five criteria, namely product completeness, interface design, service response, delivery services, and transaction processes. And has 5 alternatives namely shopee, tokopedia, bukalapak, lazada and blibli. In this study obtained from the 5 alternatives, the online shop that is most in demand by students is shopee, this can be seen from the pretension value of 0.89.
Pelatihan Kader Posyandu Remaja di Pesantren Mahasiswa Liwa’ul Haq Kelurahan Tondo Kecamatan Mantikurole
Authors: Pont Anna Veronica , Longulo Olkamien Jesdika , Mangun Mardiani 
Published: July 2022

Youth health services at posyandu can facilitate adolescents in understanding and preventing adolescent health problems. The village of Tondo does not yet have a youth posyandu. The number of adolescents in the district of Tondo: 1267 young women and 1170 boys. Community service aims to determine the knowledge and skills of adolescents in providing youth posyandu services at the Liwa'ul Haq pasantren, Tondo sub-district. The community service method is providing training for youth posyandu cadres at the Liwa'ul Haq Islamic boarding school, Tondo sub-district, training participants for 15 youths. Cadre training is divided into three stages, namely: the first is education (theory), the second is practice/role play in the classroom and the third is the practice of serving 5-table youth posyandu (stages) to adolescents. The training was carried out for 3 days by the Poltekkes Service Team of the Ministry of Health Palu in partnership with the Talise and Ponpes Liwa'ul Haq Health Center, with 15 participants. Prior to training, a pretest was conducted. After the training Posttest results the knowledge and skills of adolescents increased. It is hoped that the Head of the Talise Health Center, the Coordinator of the Youth Posyandu service will continue to fall down for the preparation of Posrem services at the Liwa'ul Haq Islamic Boarding School.

ABSTRAK
Layanan kesehatan remaja di posyandu dapat memfasilitasi remaja dalam memahami dan mencegah permasalahan kesehatan remaja. Kelurahan Tondo belum memiliki posyandu remaja. Jumlah remaja di keluruhan Tondo: remaja putri 1267 dan remaja putra 1170. Pengabdian masyarakt bertujuan diketahuinya pengetahuan dan ketrampailan remaja dalam memberikan pelayanan posyandu remaja di pasantren Liwa’ul Haq kelurahan Tondo. Metode pengabdian masyarakat adalah memberikan pelatihan kader posyandu remaja di Pasantren Liwa’ul Haq kelurahan Tondo, peserta pelatihan 15 orang remaja. Pelatihan kader dibagi menjadi tiga tahapan, yaitu: pertama adalah edukasi (teori), kedua adalah praktik/ role play di kelas dan ke tiga praktik pelayanan posyandu remaja 5 meja (tahap) kepada remaja. Pelatihan dilaksanakan selama 3 hari oleh Tim Pengabdian Poltekkes Kemenkes Palu bermitra dengan Puskesmas Talisedan Ponpes Liwa’ul Haq, peserta berjumlah 15 orang. Sebelum pelatihan dilakukan pretes. Setelah pelatihan Hasil Posttest pengetahuan dan ketrampilan remaja meningkat. Diharapakan Kepala Puskesmas Talise, Koordinator pelayanan Posyandu remaja tetap fallow up untuk persiapan pelayanan Posrem di Ponpes Liwa’ul Haq.
Nonlinear Reactor Design Optimization With Embedded Microkinetic Model Information
Authors: Ghosh Kanishka , Vernuccio Sergio , Dowling Alexander W. 
Published: July 2022

Despite the success of multiscale modeling in science and engineering, embedding molecular-level information into nonlinear reactor design and control optimization problems remains challenging. In this work, we propose a computationally tractable scale-bridging approach that incorporates information from multi-product microkinetic (MK) models with thousands of rates and chemical species into nonlinear reactor design optimization problems. We demonstrate reduced-order kinetic (ROK) modeling approaches for catalytic oligomerization in shale gas processing. We assemble a library of six candidate ROK models based on literature and MK model structure. We find that three metrics—quality of fit (e.g., mean squared logarithmic error), thermodynamic consistency (e.g., low conversion of exothermic reactions at high temperatures), and model identifiability—are all necessary to train and select ROK models. The ROK models that closely mimic the structure of the MK model offer the best compromise to emulate the product distribution. Using the four best ROK models, we optimize the temperature profiles in staged reactors to maximize conversions to heavier oligomerization products. The optimal temperature starts at 630–900K and monotonically decreases to approximately 560 K in the final stage, depending on the choice of ROK model. For all models, staging increases heavier olefin production by 2.5% and there is minimal benefit to more than four stages. The choice of ROK model, i.e., model-form uncertainty, results in a 22% difference in the objective function, which is twice the impact of parametric uncertainty; we demonstrate sequential eigendecomposition of the Fisher information matrix to identify and fix sloppy model parameters, which allows for more reliable estimation of the covariance of the identifiable calibrated model parameters. First-order uncertainty propagation determines this parametric uncertainty induces less than a 10% variability in the reactor optimization objective function. This result highlights the importance of quantifying model-form uncertainty, in addition to parametric uncertainty, in multi-scale reactor and process design and optimization. Moreover, the fast dynamic optimization solution times suggest the ROK strategy is suitable for incorporating molecular information in sequential modular or equation-oriented process simulation and optimization frameworks.
ML323 suppresses the progression of ovarian cancer via regulating USP1-mediated cell cycle
Authors: Song Baozhi , Jiang Yatao , Jiang Yu , Lin Ying , Liu Jiahua 
Published: July 2022

Background: Ubiquitin specific protease 1 (USP1) tightly correlates with poor prognosis of multiple cancers. However, whether USP1 underlies ovarian cancer (OV) progression remains unclarified.Methods: First, GSEA strategy and WGCNA analysis were used to screen for anti-ovarian cancer drugs and furthern optimal module, respectively. In addition, functional enrichments of module genes were realized by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Kaplan-Meier was then employed to analyze the prognostic impact of USP1 expression on OV patients. Cell proliferation and cell cycle assays were used to confirm biological functions of USP1 in the final.Results: Through the forementioned methods, we obtained five candidate drugs against OV from 353 anticancer drugs, and proposed ML323 as a novel anti-OV drug. As our hypothesized, ML323 significantly inhibited the proliferation of OV cells. Combined with WGCNA and KEGG analysis, the turquoise module was related to ML323, together with cell cycle. USP1 was subsequently identified as a target of ML323 and according to the TCGA database, USP1 negatively correlated with prognosis in OV, and its reduction and ML323-treatment both inhibited the proliferation of OV cells, blocking the S phase of cell cycle in vitro.Conclusion: Taken together, ML323 exerts its inhibitory effect on the proliferation of OV cells by targeting USP1-regulated cell cycle, providing a therapeutical strategy and potential target against OV.
Association Between Polymorphisms in Estrogen Receptor Genes and Depression in Women: A Meta-Analysis
Authors: Li Cuifen , Xie Manli , Wang Weiwei , Liu Yanyan , Liao Dan , Yin Jingwen , Huang Hao 
Published: July 2022

Objective: It is suggested that estrogen receptors (ERs) might be associated with the disproportionate vulnerability of women to depressive episodes. Several variants in ER-alpha (ERα) and ER-beta (ERβ) have been linked to depression, but the results were not consistent. Hence, we conducted a meta-analysis to evaluate the association between ERα/ERβ and depression in a cohort of women.Methods: A comprehensive literature search was performed in public databases. The genetic association between polymorphisms in Erα/ERβ and depression risk in a cohort of women was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). Cochran’s Q test and the I2 index were used to evaluate heterogeneity.Results: In total, 10 studies and 4 SNPs (rs2234693, rs9340799, rs4986938, rs1256049) were included in our meta-analysis. rs2234693 genotype was significantly associated with the risk of depression in women by dominant model (CC + CT vs TT, OR = 1.30, 95% CI: 1.09–1.55, p = 0.0031), recessive model (CC vs CT + TT, OR = 1.64, 95% CI: 1.00–2.67, p = 0.0478), additive model (CC vs TT, OR = 1.93, 95% CI: 1.12–3.35, p = 0.0189) and allelic model (C vs T, OR = 1.24, 95% CI: 1.10–1.39, p = 0.0003). For rs9340799, the frequencies of risk genotypes according to the dominant (GG + GA vs AA, OR = 1.47, 95% CI = 1.10–1.98, p = 0.0096, I2 = 0%, p = 0.43) and allelic (G vs A, OR = 1.33, 95% CI: 1.04–1.69, p = 0.0236, I2 = 0%, p = 0.39) models were significantly lower in women with depression than in controls within the Asian subgroup. For rs1256049, risk genotypes were significantly more frequent in depressed subjects than in controls under the dominant model (AA+ GA vs GG, OR = 1.62, 95% CI: 1.19–2.21, p = 0.0024) and the allelic model (A vs G, OR = 1.35, 95% CI: 1.07–1.72, p = 0.012) after sensitivity analysis by omitting one study which induce the heterogeneity.Conclusions: The current meta-analysis is the first and most comprehensive investigation of the association between ERs and depression in women, and the findings support the concept that ERs participate in the etiology of sex heterogeneity in depression.
A Novel Method to Quantify Self-Healing Capabilities of Fiber-Reinforced Polymers
Authors: Scazzoli Cecilia , Trigueira Robin , Cohades Amaël , Michaud Véronique 
Published: July 2022

The present work investigates a novel and practical method to evaluate the healing efficiency of carbon-reinforced polymer composites. The method should be representative of damage occurring during the lifetime of a composite part, should tend to damage the healable matrix mostly and yet be simple and cost-effective to set up. Thus, the capacity to recover low-velocity impact damage has been evaluated via three-point bending flexural tests. Carbon-reinforced composite laminates were produced using HealTech™ T300-TW200-42RW-1250, a commercial healable resin pre-impregnated Torayca T300 3K twill 2 × 2 fabric with an aerial weight of 200 g/m2. Fibers were oriented at ± 45° or at 0°–90°, and the laminates were impacted at different energy levels. Flexural properties of undamaged, damaged, and healed samples were compared, and the healing efficiency was calculated as the ratio of healed and undamaged ultimate flexural strength or modulus. Since matrix healing efficiency is the value to characterize, it was shown that ±45° laminates could be tested without major fiber damage and, thus, provide the best matrix healing efficiency results. Such a method proved to be 1) representative of early-stage damage of composite FRPs often occurring in the form of delamination or matrix microcracking, and 2) a fast and reliable characterization technique requiring the use of a limited amount of material.
The Interplay Between Use of Biological Therapies, Psychological State, and the Microbiome in IBD
Authors: Tavakoli Paris , Vollmer-Conna Ute , Hadzi-Pavlovic Dusan , Vázquez-Campos Xabier , Grimm Michael Carl 
Published: July 2022

BackgroundThis study examines longitudinal bio-psychological dynamics and their interplay in IBD patients undergoing conventional and biological therapies.MethodsFifty IBD participants (24 UC, 26 CD) in clinical remission were followed for 12 months. Complete longitudinal datasets, biological samples, validated scores of psychological status were collected monthly for analysis of association. Microbiome analysis was performed to identify microbial dynamics and signatures. Patients were grouped on disease phenotype (CD, UC) and mode of treatment (biological therapies, non-biological treatment). General linear models, mixed models, cluster analysis, and analyses of variance were used to examine the longitudinal trends of the variables and their associations over time. Results were corrected for multiple testing.ResultsResults substantiated different interactions between biological therapy and longitudinal trends of inflammatory biomarkers in remission CD and UC patients as well as significant differences between CD and UC patients in their psychological measures during clinical remission, with UC patients having inferior condition compared to CD. A significant reduction in microbial diversity in CD patients compared to UC was identified. Results characterized considerable differences in longitudinal microbial profile between those taking and not taking biological treatment in UC patients, but not in CD patients.ConclusionA different trajectory of interdependence was identified between psychological state, sleep, and microbial dynamics with mode of treatment when compared between CD and UC patients. Further studies should investigate the causal relationships between bio-psychological factors for improved treatment purposes.