bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visuo-proprioceptive recalibration and the sensorimotor map
Authors: Block Hannah J. , Liu Yang 
Published: November 2022

ABSTRACTSpatial perception of our hand is closely linked to our ability to move the hand accurately. We might therefore expect that reach planning would take into account any changes in perceived hand position; in other words, that perception and action relating to the hand should depend on a common sensorimotor map. However, there is evidence to suggest that changes in perceived hand position affect a body representation that functions separately from the body representation used to control movement. Here we examined target-directed reaching before and after participants either did (Mismatch group) or did not (Veridical group) experience a cue conflict known to elicit recalibration in perceived hand position. For the reaching task, participants grasped a robotic manipulandum that positioned their unseen hand for each trial. Participants then briskly moved the handle straight ahead to a visual target, receiving no performance feedback. For the perceptual calibration task, participants estimated the locations of visual, proprioceptive, or combined cues about their unseen hand. The Mismatch group experienced a gradual 70 mm forward mismatch between visual and proprioceptive cues, resulting in forward proprioceptive recalibration. Participants made significantly shorter reaches after this manipulation, consistent with feeling their hand to be further forward than it was, but reaching performance returned to baseline levels after only 10 reaches. The Veridical group, after exposure to veridically-aligned visual and proprioceptive cues about the hand, showed no change in reach distance. These results are not fully consistent with a single common sensorimotor map, but could suggest multiple, interacting body representations.NEW & NOTEWORTHYIf perceived hand position changes, we might assume this affects the sensorimotor map and, in turn, reaches made with that hand. However, there is evidence for separate body representations involved in perception vs. action. After a cross-sensory conflict that results in proprioceptive recalibration in the forward direction, participants made shorter reaches as predicted, but only briefly. This is not fully consistent with a single common sensorimotor map, but could suggest multiple, interacting body representations.
A Brain-Wide Genome-Wide Association Study of Candidate Quantitative Trait Loci Associated with Structural and Functional Phenotypes of Pain Sensitivity
Authors: Zhang Li , Pan Yiwen , Huang Gan , Liang Zhen , Li Linling , Zhang Zhiguo 
Published: November 2022

AbstractIndividual pain sensitivity is influenced by many factors, such as the differentiation of brain regional features and genetic variations. However, its heritability remains largely unclear. The present study conducted a brain-wide genome-wide association study (GWAS) to explore the genetic bases of structural and functional neuroimage phenotypes of pain sensitivity. In total 432 normal participants were firstly divided into high and low pain sensitivity groups according to laser quantitative test threshold and related brain regions’ gray matter density (GMD) features were identified. Consequently, GWAS was performed on each GMD phenotype using quality-controlled genotypes. Based on the heatmap and hierarchical clustering results from GWAS, the right insula was selected for further refined analysis in terms of sub-regions GMD and resting-state functional connectivity (rs-FC) phenotypes. The results indicate that the right insula GMD in the high sensitivity group is significantly lower than the low sensitivity group. Also, the TT/TC group at locus rs187974 may lead to a lower GMD in the right insula than the CC group. Meanwhile, loci at gene CYP2D6 may lead to a variation of rs-FC between the right insula and left putamen. In conclusion, our study suggests multiple candidate loci associated with pain sensitivity that may influence brain phenotypes.
SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody Responses and Passive Transfer Via The Placenta And Breastmilk
Authors: Marshall Nicole E. , Blanton Madison B. , Doratt Brianna M. , Malherbe Delphine C. , Rincon Monica , True Heather , Mcdonald Taylor , Beauregard Caroline , Adatorwovor Reuben , Messaoudi Ilhem 
Published: November 2022

ABSTRACTBackgroundInfection during pregnancy can result in adverse outcomes for both pregnant persons and offspring. Maternal vaccination is an effective mechanism to protect both mother and neonate into post-partum. However, our understanding of passive transfer of antibodies elicited by maternal SARS-CoV-2 mRNA vaccination during pregnancy remains incomplete.ObjectiveWe aimed to evaluate the antibody responses engendered by maternal SARS-CoV-2 vaccination following initial and booster doses in maternal circulation and breastmilk to better understand passive immunization of the newborn.Study DesignWe collected longitudinal blood samples from 121 pregnant women who received SARS-CoV-2 mRNA vaccines spanning from early gestation to delivery followed by collection of blood samples and breastmilk between delivery and 12 months post-partum. During the study, 70% of the participants also received a booster post-partum. Paired maternal plasma, breastmilk, umbilical cord plasma, and newborn plasma samples were tested via enzyme-linked immunosorbent assays (ELISA) to evaluate SARS-CoV-2 specific IgG antibody levels.ResultsVaccine-elicited maternal antibodies were detected in both cord blood and newborn blood, albeit at lower levels than maternal circulation, demonstrating transplacental passive immunization. Booster vaccination significantly increased spike specific IgG antibody titers in maternal plasma and breastmilk. Finally, SARS-CoV-2 specific IgG antibodies in newborn blood correlated negatively with days post initial maternal vaccine dose.ConclusionVaccine-induced maternal SARS-CoV-2 antibodies were passively transferred to the offspringin uterovia the placenta and after birth via breastfeeding. Maternal booster vaccination, regardless of gestational age at maternal vaccination, significantly increased antibody levels in breastmilk and maternal plasma, indicating the importance of this additional dose to maximize passive protection against SARS-CoV-2 infection for neonates and infants until vaccination eligibility.
Cell dichotomous role of STING in pulmonary hypertension
Authors: Pham Ann T. , Oliveira Aline C. , Fu Chunhua , Alves Matthew D. , Dupee Zadia , Mukhsinova Laylo , Ebrahimi Elnaz , Patel Harsh , Patel Reeha , Nguyen Amy , Jin Lei , Bryant Andrew J. 
Published: November 2022

AbstractRationalePatients with constitutive activation of DNA sensing pathway through stimulator of interferon genes (STING), such as those with STING-Associated Vasculopathy with onset in Infancy (SAVI), frequently have complications related to pulmonary hypertension (PH). However, the role of STING-signaling in adult PH patients is heretofore undescribed.ObjectiveTo investigate the role of STING in PH development.Methods and ResultsPH was induced in global STING deficient or cell-specific STING deficient mice using either bleomycin or chronic hypoxia exposure. PH development was evaluated with right ventricular systolic pressure, Fulton index, histological and flow cytometric measurements. STING expression in patient lungs were examined using both immunohistochemistry and flow cytometry. Herein, we describe how STING overactivation in a SAVI mouse model results in a baseline elevation in pulmonary pressures, while global STING deficiency protects mice from PH development. Furthermore, STING-associated PH appears to be independent of type I Interferon (IFN) signaling. We further demonstrate a cellular dichotomous role of STING in PH development with STING expression by smooth muscle cells contributing to PH, and its activation on myeloid cells being pivotal in severe disease prevention. Finally, we demonstrate a STING-PD-L1 axis as necessary for disease progression, suggesting future potential therapeutic applications.ConclusionsOverall, these data provide concrete evidence of STING involvement in PH, establishing biologic plausibility for STING-related therapies in PH treatment.Graphical abstract
PAMP-Induced secreted Peptide-Like 6 (PIPL6) functions as an amplifier of plant immune response through RLK7 and WRKY33 module
Authors: Najafi Javad , Gjennestad Ragnhild Sødal , Kissen Ralph , Brembu Tore , Bartosova Zdenka , Winge Per , Bones Atle M 
Published: November 2022

AbstractPlant peptide hormones are engaged in the regulation of plant developmental programs and immunity. PAMP-Induced Peptide (PIP) hormones are new class of signaling peptide with diverse functional roles in the regulation of plant development and stress responses. In this study, we have investigated the function of PAMP-Induced secreted Peptide-Like 6 (PIPL6) as an amplifier of plant immunity against necrotrophic fungal pathogens inArabidopsis thaliana. We have applied an integrated omics approach to unveil the function and downstream signaling pathways initiated by PIPL6.PIPL6is highly and transiently induced by treatment with different elicitors. Exogenous application of synthetic peptide designed from the C-terminal conserved domain of PIPL6 resulted in strong transcriptional induction of many genes involved in the regulation of plant immunity. Further gene expression analysis revealed that induction of marker genes by PIPL6 peptide requires the receptor-like kinase 7 (RLK7). Immunoblotting and gene expression analysis demonstrated that exogenous applications of PIPL6 peptide activates MAPK6, MAPK3, and WRKY33 module in an RLK7-dependent manner. The levels of salicylic acid, jasmonic acid, camalexin, and glucosinolates were differentially regulated inPIPL6knock-down and overexpression lines challenged by necrotrophic pathogenBotrytis cinerea. Bioassays using the necrotrophic fungal pathogensBotrytis cinereaandAlternaria brassicaeshowed thatpipl6knock-down lines were more susceptible to these pathogens whilePIPL6overexpression lines exhibited enhanced resistance. Altogether, these results indicate that the PIPL6 peptide functions as a new damage-associated molecular pattern (DAMP) and acts as an amplifier of Arabidopsis immunity.
Effects of personal environmental awareness and environmental concern on employees' voluntary pro-environmental behavior: a mediation analysis in emerging countries
Authors: Saifulina Nailya , Carballo-Penela Adolfo , Ruzo-Sanmartín Emilio 
Published: November 2022

PurposeSuccessful stimulation of employee engagement in pro-environmental behavior (PEB) at work can reduce organizational environmental footprint and boost its green performance. The aim of this paper is to investigate the individual factors that may promote such behavior at work, offering a complex model with mediating relationships not studied before.Design/methodology/approachIn this paper data was collected through a survey of 331 bank employees from different banks in Kazakhstan and Ecuador. Structural equation modeling was used to test the relationships between the different constructs.FindingsThe results identified that environmental values and attitudes mediate the relationship between (1) personal environmental awareness and (2) environmental concern and employees' voluntary PEB at work. Harmonious environmental passion (HEP) mediates the relationship between environmental values and attitudes and employees' voluntary PEB at work.Practical implicationsThis study presents important organizational policymaking implications with regard to organizational greening. The importance of environmental awareness is underlined, guiding managers to offer environmental education and training to the employees with the aim of improving environmental knowledge that may lead to employees' voluntary PEB at work. Also, managers should work on enhancing HEP.Originality/valuePrior literature on this topic is still scarce. This research presents important contributions by discussing how individual antecedents may act as stimuli of employees' voluntary PEB at work in the context of the banking sector in two emerging countries that are often neglected by prior literature.
Typographic design of outdoor signage, restaurant authenticity, and consumers’ willingness to dine: extending semiotic theory
Authors: Song Hanqun , Ding Qing Shan , Xu Jing Bill , Kim Jonghyeong , Chang Richard C.Y. 
Published: November 2022

PurposeRestaurants’ outdoor signage plays an irreplaceable role in attracting potential diners, as it conveys important functional and symbolic meanings of the businesses. The purpose of this study is to investigate the effect of typographic design elements of outdoor signage on consumers’ perceptions of authenticity. This study also tests the linkage between authenticity and willingness to dine, as well as the moderating effect of frequency of dining in ethnic restaurants on the relationship.Design/methodology/approachUsing a 2 (simplified vs traditional Chinese characters) × 2 (calligraphy vs computer font) × 2 (vertical vs horizontal text flow) between-subject design, the authors did two experiments with 786 Chinese diners. Restaurant authenticity and willingness to dine are dependent variables, and openness to ethnic cuisine is the control variable.FindingsDisplay characters and text flow significantly affect restaurant authenticity. Furthermore, the results of this study demonstrate that display characters interact with typeface to influence restaurant authenticity. Consumers’ perceived authenticity significantly increases their willingness to dine. The frequency of dining in ethnic restaurants moderates the relationship between restaurant authenticity and willingness to dine.Practical implicationsEthnic restaurateurs should pay attention to the outdoor signage design, as it affects potential consumers’ authenticity perceptions. Specifically, in Mainland China, traditional Chinese characters and vertical text direction increase potential consumers’ authenticity perceptions.Originality/valueThis study extends the semiotic theory and applies the cue–judgment–behavior model in the hospitality literature. This study also provides new understanding of authenticity by identifying the influence of typographic design on authenticity, which confirms the semiotic theory that certain semiotic cues affect consumers’ judgments.
Parametric mathematical modeling and 3D response surface analysis for rod to plate friction welding of AISI 1020 steel/AISI 1018 steel
Authors: Thirumalaikkannan Dhamothara kannan , Paramasivam Sivaraj , Visvalingam Balasubramanian , Sonar Tushar , Sivaraj Sathiya 
Published: November 2022

PurposeRotary friction welding (RFW) was used to solve the issues in fusion welding of rod to plate joints of low carbon steel (AISI 1020 steel/AISI 1018 steel) such solidification cracking, wider heat affected zone (HAZ), lower HAZ hardness, high residual stresses and distortion. The main objective of this investigation is to develop parametric mathematic models (PMMs), 3D response surface analysis to predict tensile strength (TS) and weld interface hardness (WIH) of rod to plate joints and correlate microstructure with TS and WIH of rod to plate joints.Design/methodology/approachThe three-factor x five-level central composite design (CCD) consisting fewer experiments was employed for designing experimental matrix. The tensile and microhardness tests were performed to evaluate mechanical performance of joints. The PMMs of TS and WIH of rod to plate joints were developed using polynomial regression equations incorporating the RFW parameters. The 3D response surfaces were developed using response surface methodology (RSM) to optimize RFW parameters for joining AISI 1020/AISI 1018 rod to plate.FindingsThe joints made using friction pressure/friction time (FRNP/FRNT) of 3.71 MPa/s, forging pressure/forging time (FRGP/FRGT) of 3.71 MPa/s and rotational speed (RTSP) of 19.99 rps exhibited higher TS and WIH of 452 MPa and 252 HV0.5. The PMMs accurately predicted TS and WIH of rod to plate joints at less than 1.5% error and 95% confidence. The RTSP revealed greater effect on TS and WIH of rod to plate joints followed by FRGP/FRGT and FRNP/FRNT. The superior TS and WIH of joints developed using optimized process parameters is correlated to the evolution of finer bainitic microstructure in weld interface due to the dynamic recrystallization of grains ensued by optimum frictional heating and plastic deformation.Originality/valueThe PMMs were developed for predicting TS and WIH of joints. The RFW parameters were optimized to enhance TS and WIH of joints. Low carbon steel rod to plates joints were developed using RFW for automotive applications without fusion welding defects. The microstructural features of low strength and high strength rod to plate joints were correlated to the TS and WIH of rod to plate joints.
Evaluation of organizational variables of quality 4.0 in digital transformation: the study of an Indian manufacturing company
Authors: Mittal Ankesh , Kumar Vimal , Verma Pratima , Singh Arpit 
Published: November 2022

PurposeThe study aims to identify organizational variables of quality 4.0 for an Indian manufacturing company in the case of digital transformation. Furthermore, the organization enhances its quality 4.0 performances to its success based on the degree of relevance of these variables, insight into these variables and sub-factors to prioritize them.Design/methodology/approachInitially, two rounds of the survey were conducted with 11 decision-makers from the company made to receive organizational variables scores and prioritize the factors and sub-factors. Analytic Hierarchy Process (AHP) based research methodology has been proposed to assign the criterion weights and prioritize the identified variables.FindingsThe results of this AHP model demonstrate that “Committed Leadership” is recognized as the top positioned variable and most significant organizational variable, followed by Collaboration and Quality culture, which are developed at the next level. These essential organizational variables with their sub-categories' priorities are identified as contributing attributes.Research limitations/implicationsThe findings facilitate quality 4.0 in the digitalization era, which take into contemplating the current state of the business. Furthermore, the understanding of variables provides insightful guidance to analyze, solve complex problems and assess the efficacy of quality 4.0 in digital transformation.Originality/valueThe novelty of this study is to pinpoint, and evaluate the responsible organizational variables and prioritize them that lead to high productivity and competitive advantage considering the AHP method.
Local tourists' perceptions of tourist destinations' competitiveness: a comparative study of the United Arab Emirates, Egypt, and Oman
Authors: Abou-Shouk Mohamed , Zoair Nagoua , Elbaz Ahmed Mohamed , Abdel-Jalil Marwa 
Published: November 2022

PurposeDestination competitiveness is a significant contributor to tourism growth, performance and development. The current research intends to test the effect of the dimensions of the Travel and Tourism Competitiveness Index (TTCI) on destination competitiveness in the United Arab Emirates (UAE), Egypt and Oman and how competitiveness influences tourism performance and development.Design/methodology/approachThe perspectives of 460 responses were collected from the UAE, 457 from Egypt and 301 responses from Oman. Partial least squares structural equation modelling (PLS-SEM) was utilised to measure the research model relationships.FindingsThe results showed that the competitiveness index components are significantly contributing to destination competitiveness and that this competitiveness is predicting both tourism performance and development.Originality/valueThis study developed and empirically tested the effect of an integrative model of the competitiveness index on destination competitiveness from the perspective of local visitors in three Muslim and Arab nations. This study gives scholars valuable perceptions into how socio-cultural variations between residents and locals in various nations might result in significantly diverse behaviours.
Random noise attenuation of ocean bottom seismometers based on a substep deep denoising autoencoder
Authors: Lin Haoran , Xu Jian , Xing Lei , Li Qianqian , Liu Huaishan 
Published: November 2022

AbstractOcean bottom seismometer data usually contain a large amount of random noise, which seriously reduces the signal‐to‐noise ratio of the data and affects subsequent imaging. Hence, random noise attenuation is one of the most essential steps in ocean bottom seismometer data processing. In this paper, a novel approach is proposed to attenuate the marine seismic random noise of ocean bottom seismometers based on a six‐dense‐layer denoising autoencoder. We input the domain data into the denoising autoencoder, the encoder compresses the signal and noise and extracts the main features and the decoder finally reconstructs the denoised data with the same dimension as the input. In this approach, because few raw labelled examples are available, we first constructed the pretraining, training and test data sets by patch processing. Then, we pretrained the encoder based on clean synthetic seismic data through unsupervised learning and pretrained the decoder based on noisy synthetic seismic data through supervised learning. Next, the pretrained model was fine‐tuned with the encoder–decoder on a raw seismic data set in an unsupervised manner. Finally, we used the model to attenuate the random noise in raw ocean bottom seismometer data for testing. Synthetic and raw examples are used to compare the deconvolution, multichannel singular spectrum analysis, deep denoising autoencoder and substep deep denoising autoencoder approaches. Experimental tests demonstrate that the proposed method has higher processing efficiency and precision.
Everyday Economy and Levelling Up
Authors: Raikes Luke 
Published: November 2022

AbstractLevelling up and the everyday economy are two crucial concepts for understanding the direction of policy making in the UK, but the relationship between them has not yet been fully explored. Moreover, the UK's industrial and regional policies are woefully underdeveloped. This article suggests how levelling up and the everyday economy concepts could contribute to Labour's emerging industrial and regional policies. It argues that Labour is right to pursue an economic growth agenda, but must make growth work for communities and workers, and the everyday economy can help. The everyday economy can contribute to, and benefit from, local productivity growth, but regions still need companies that export or are at the technological frontier to raise demand, productivity and pay. Labour should work with the government's Levelling Up White Paper, but this was overly focussed on cities and knowledge intensive business services: there is an economic case for including towns and manufacturing too, and they should prioritise connecting places and sectors, building on the diverse strengths which different places can offer, and setting a long‐term direction of travel. Over time, Labour should try to ensure that cities, towns and smaller communities are better connected, better coordinated and more specialised within larger regions. Labour should, therefore, set out an industrial and regional strategy; work up an economic development toolkit; and devolve economic powers to Mayoral Combined Authorities and councils.