bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical and Antibacterial Properties of h-BN-TiO2 Nanocomposite-Modified Glass Ionomer Cement
Authors: Ma Yu , Guo Yan-Zhu , Liu Yan , Wang Yu-Rui , Yang Jiang-Chuan , Kong Xin-Zi , Jia Hong-Lin , Li Rui-Zhi , Han Qi-Ze , Zheng Cheng-Dong , Hu Xin-Jun , Liu Bin 
Published: May 2022

This study investigated the mechanical properties and antibacterial properties of hexagonal boron nitride and titanium dioxide (h-BN-TiO2) nanocomposite modified traditional glass ionomer cement. The mechanism of formation of the h-BN-TiO2 nanocomposite was elucidated by conducting molecular dynamics (MD) simulations using the Material Studio (MS) software. Furthermore, synthesis of h-BN-TiO2 nanocomposite by the original growth method using hexagonal boron nitride nanosheets (h-BNNs) and titanium dioxide nanoparticles (TiO2 Nps) and characterization using TEM and AFM to determine their particle sizes, morphologies, and structures. The mechanical properties and antibacterial efficacies of the glass ionomer cement composites were analyzed based on the different mass fractions (0, 0.3, 0.7, 1.1, and 1.5 wt%) of the h-BN-TiO2 nanocomposite. The results showed when the concentration of the h-BN-TiO2 nanocomposite was 1.1 wt%, the Compressive strength (CS) and Vicker hardness (VHN) were 80.2% and 149.65% higher, respectively, compared to the glass ionomer cement without any h-BN-TiO2 nanocomposite. Also, the increase in the concentration of the h-BN-TiO2 nanocomposite led to a decrease in both the coefficient of friction (COF) and solubility, but a 93.4% increase in the antibacterial properties of the glass ionomer cement composites. The cell survival rate of each group was more than 70% after 48 h, but the difference was not statistically significant (p &gt; 0.05). Therefore, the h-BN-TiO2 nanocomposite served as a reinforcing material for glass ionomer cement, which can be useful in clinical dentistry and provide a new strategy for improving the clinical utility of glass ionomer cement.
Multi-Omics Characterization of a Glycerolipid Metabolism-Related Gene Enrichment Score in Colon Cancer
Authors: Wang Zhiyu , Zhang Zhuoqi , Zhang Ke , Zhou Qiaoxia , Chen Sidong , Zheng Hao , Wang Guoqiang , Cai Shangli , Wang Fujing , Li Shenglong 
Published: May 2022

BackgroundGlycerolipid metabolism is involved in the genesis and progression of colon cancer. The current study aims at exploring the prognostic value and potential molecular mechanism of glycerolipid metabolism-related genes in colon cancer from the perspective of multi-omics.MethodsClinical information and mRNA expression data of patients with colon cancer were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Single-sample gene set enrichment analysis (ssGSEA) was applied to calculate the glycerolipid metabolism-related gene enrichment score (GLMS). Univariable and multivariable Cox regression analyses were used to study the prognostic value of GLMS in TCGA-COAD and GSE39582 cohorts. The molecular mechanism of the prognostic factor was investigated via immune cell infiltration estimation and correlation analysis of cancer hallmark pathways. Single-cell transcriptomic dataset GSE146771 was used to identify the cell populations which glycerolipid metabolism targeted on.ResultsThe GLMS was found to be associated with tumor location and consensus molecular types (CMSs) of colon cancer in TCGA-COAD cohort (P &lt; 0.05). Patients in the low-GLMS group exhibited poorer overall survival (OS) in TCGA cohort (P = 0.03; HR, 0.63; 95% CI, 0.42–0.94), which was further validated in the GSE39582 dataset (P &lt; 0.001; HR, 0.57; 95% CI, 0.43–0.76). The association between the GLMS and OS remained significant in the multivariable analysis (TCGA cohort: P = 0.04; HR, 0.64; 95% CI, 0.42–0.98; GSE39582 cohort: P &lt; 0.001; HR, 0.60; 95% CI, 0.45–0.80). The GLMS was positively correlated with cancer hallmark pathways including bile acid metabolism, xenobiotic metabolism, and peroxisome and negatively correlated with pathways such as interferon gamma response, allograft rejection, apoptosis, and inflammatory response (P &lt; 0.05). Increased immune infiltration and upregulated expression of immune checkpoints were observed in patients with lower GLMS (P &lt; 0.05). Single-cell datasets verified the different distribution of GLMS in cell subsets, with significant enrichment of GLMS in malignant cells and Tprolif cells.ConclusionWe demonstrated that GLMS was a potential independent prognostic factor for colon cancer. The GLMS was also correlated with several cancer hallmark pathways, as well as immune microenvironment.
Evidence of Chinese Herbal Medicine Use From an Economic Perspective: A Systematic Review of Pharmacoeconomics Studies Over Two Decades
Authors: Xiong Xiaomo , Jiang Xiangxiang , Lv Gang , Yuan Jing , Li Minghui , Lu Z. Kevin 
Published: May 2022

Objectives:Pharmacoeconomics evaluation (PE) is increasingly used in the healthcare decision-making process in China. Little is known about PE conducted in Chinese Herbal Medicines (CHMs). We aimed to systematically review trends, characteristics, and quality of PE of CHMS.Methods:We systematically searched both Chinese (CNKI, WanFang, and VIP) and English (Pubmed) databases. Studies were included if they were PE studies comparing both costs and outcomes between two or more interventions published in Chinese or English. Assessment of the quality of studies was conducted using the Quality of Health Economic Analyses (QHES) instrument.T-test and Chi-square tests were used to compare the studies before and after the first edition ofChina Guidelines for PEpublished in 2011, and between studies published in Chinese and English.Results:A total of 201 articles were included. There was an increasing trend of PE studies on CHMs during the study period. The top three studied diseases were central nervous system (CNS), mental, and behavioral disorders; cardiovascular diseases; and blood, immune and endocrine diseases. The average QHES score for the included studies was 63.37. Cost-effectiveness analysis (CEA) accounted for the majority (76.6%) of the included studies. Only a quarter of the articles (27.4%) were funded, and there were significantly more studies funded after the publication ofChina guidelines for PE. About 96.5% of studies did not specify evaluation perspectives and 89.6% of studies had a sample size of less than 300. Around half of the studies (55%) used incremental analysis, but only a few of them considered using a threshold. Half of the studies lacked sensitivity analysis. There was no significant improvement in the quality of studies published after the publication ofChina Guidelines for PE, and English articles had significantly higher quality than Chinese articles.Conclusion:This study identified several problems in PE studies on CHMs, including having small sample sizes, lacking necessary research elements, and using single evaluation methods. The quality of PE studies on CHMs was not sufficient. Researchers need to understand the standardized way to conduct PE studies and improve the quality and level of PE studies on CHMs.
Investigation of the Anti-Inflammatory Activity of Fusaproliferin Analogues Guided by Transcriptome Analysis
Authors: Kuang Qi-Xuan , Lei Li-Rong , Li Qing-Zhou , Peng Wan , Wang Yu-Mei , Dai Yi-Fei , Wang Dong , Gu Yu-Cheng , Deng Yun , Guo Da-Le 
Published: May 2022

Background: Excessive inflammation results in severe tissue damage as well as serious acute or chronic disorders, and extensive research has focused on finding new anti-inflammatory hit compounds with safety and efficacy profiles from natural products. As promising therapeutic entities for the treatment of inflammation-related diseases, fusaproliferin and its analogs have attracted great interest. However, the underlying anti-inflammatory mechanism is still poorly understood and deserves to be further investigated.Methods: For the estimation of the anti-inflammatory activity of fusaproliferin (1) and its analogs (2-4)in vitro and in vivo, lipopolysaccharide (LPS)-induced RAW264.7 macrophages and zebrafish embryos were employed. Then, transcriptome analysis was applied to guide subsequent western blot analysis of critical proteins in related signaling pathways. Surface plasmon resonance assays (SPR) combined with molecular docking analyses were finally applied to evaluate the affinity interactions between 1-4 and TLR4 and provide a possible interpretation of the downregulation of related signaling pathways.Results: 1-4 significantly attenuated the production of inflammatory messengers, including nitric oxide (NO), reactive oxygen species (ROS), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), as well as nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-induced RAW264.7 macrophages. Transcriptome analyses based on RNA-seq indicated the ability of compound 1 to reverse LPS stimulation and the nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPKs) signaling pathways contribute to the anti-inflammatory process. Experimental verification at the protein level revealed that 1 can inhibit the activation of inhibitor of NF-κB kinase (IKK), degradation of inhibitor of NF-κB (IκB), and phosphorylation of NF-κB and reduce nuclear translocation of NF-κB. 1 also decreased the phosphorylation of MAPKs, including p38, extracellular regulated protein kinases (ERK), and c-Jun N-terminal kinase (JNK). SPR assays and molecular docking results indicated that 1-4 exhibited affinity for the TLR4 protein with KD values of 23.5–29.3 μM.Conclusion: Fusaproliferin and its analogs can be hit compounds for the treatment of inflammation-associated diseases.
Neutral Polysaccharides From Hohenbuehelia serotina With Hypoglycemic Effects in a Type 2 Diabetic Mouse Model
Authors: Liu Qinghong , Wu Jing , Wang Peng , Lu Yuxiao , Ban Xinhe 
Published: May 2022

Neutral polysaccharides (NHSPs) from the mushroom Hohenbueheliaserotina were purified by D301/D152 resin ion-exchange chromatography and DEAE-cellulose anion exchange chromatography. The weight-average molecular weight (MW) and number-average molecular weight (Mn) of NHSP were 1,821 and 820.55 kDa, respectively. A monosaccharide component analysis showed that NHSP was composed of glucose, galactose, and mannose in molar ratio 2.6:2.1:1.0. FT-IR and NMR (1H and HSQC) spectroscopic analyses revealed that NHSP contained mainly 1,3-linked β-D-glucose, 1,4-linked β-D-glucose, 1,6-linked β-D-mannose, 1,6-linked α-D-mannose, and 1,6-linked β-D-galactose. The thermogravimetric analysis (TGA) showed that NHSP has good thermal stability below 250°C. NHSP notably reduced the blood glucose level (hypoglycemic effect) at dose 200 mg/kg for 21 days in a type 2 diabetic mouse model. NHSP reduced the liver index significantly, suggesting that it may help prevent hepatic steatosis or hepatomegaly.
Analgesic Effects and Safety of Dexmedetomidine Added to Nalbuphine or Sufentanil Patient-Controlled Intravenous Analgesia for Children After Tonsillectomy Adenoidectomy
Authors: Jia Yingping , Zhou Rui , Li Zhengchen , Wang Yuanyuan , Chen Sandong , Zhao Liyuan , Shao Yi , Qi Jinlian 
Published: May 2022

Tonsillectomy is a frequently performed surgical procedure in children, requiring post-operative analgesia. This study evaluated the efficacy and safety of nalbuphine or sufentanil combined with dexmedetomidine for patient-controlled intravenous analgesia (PCIA) after pediatric tonsillectomy adenoidectomy. A total of 400 patients undergoing tonsillectomy with and without adenoidectomy were included in the study. Patients received a PCIA pump (0.5 mg/kg nalbuphine, 2 μg/kg dexmedetomidine and 0.9% sodium chloride to a total volume of 100 ml) for postoperative pain management were classified into Group ND (n = 200). Patients received a PCIA pump (2 μg/kg sufentanil, 2 μg/kg dexmedetomidine and 0.9% sodium chloride to a total volume of 100 ml) for postoperative pain management were classified into Group SD (n = 200). More stable hemodynamic changes were noted in Group ND than Group SD from 1 h to 48 h after operation. At 6, 12, 24, and 48 h after operation, the children in Group ND had higher Ramsay sedation scores than those in Group SD. The times to push the PCIA button in Group ND and Group SD were 2.44 ± 0.74 and 2.62 ± 1.00, showing significant differences (p = 0.041). The VASR scores of children in Group ND were significantly lower within 6, 12, and 24 h than those in Group SD (p &lt; 0.05). The VASC scores of children in Group ND were significantly lower within four time points (2, 6, 12, and 24 h) than those in Group SD (p &lt; 0.05). At 1st day after surgery, the children in Group ND had lower levels of serum ACTH, IL-6, and COR levels than those in Group SD (p &lt; 0.001). The incidence rates of nausea and vomiting, and pruritus were significantly higher in Group SD than Group ND (5.00% vs. 11.00%, p = 0.028; 1.00% vs. 4.50%, p = 0.032). The total incidence rate of adverse reactions was significantly higher in Group SD than Group ND (15.00% vs. 31.00%, p = 0.0001). The study demonstrated that dexmedetomidine added to nalbuphine PCIA enhanced the analgesic effects, attenuated the postoperative pain, and reduced the stress response after pediatric tonsillectomy adenoidectomy.
Blood Metabolomics Analysis Identifies Differential Serum Metabolites in Elite and Sub-elite Swimmers
Authors: Cai Ming , Wu Chao , Jing Chen , Shen Xunzhang , He Mian , Wang Liyan , Guo Qi , Yan Yan , Yan Xu , Yang Ruoyu 
Published: May 2022

Objective: Metabolites in body fluids, such as lactate, glucose, and creatinine, have been measured by conventional methods to evaluate physical function and performance or athletic status. The objectives of the current study were to explore the novel metabolite biomarkers in professional swimmers with different competition levels using nuclear magnetic resonance (NMR) metabolomics, and try to establish a model to identify the athletic status or predict the competitive potential.Methods: Serum samples were collected from 103 elite and 84 sub-elite level Chinese professional swimmers, and were profiled by NMR analysis.Results: Out of the thirty-six serum metabolites profiled, ten were associated with the athletic status of swimmers (with p &lt; 0.05). When compared with sub-elite swimmers, elite swimmers had higher levels of high-density lipoprotein (HDL), unsaturated fatty acid, lactic acid, and methanol. Elite swimmers had lower levels of isoleucine, 3-hydroxybutyric acid, acetoacetate, glutamine, glycine, and α-glucose. A model with four metabolites, including HDL, glutamine, methanol, and α-glucose, was established to predict athletic status by adjusting with different covariates. The area under the curve (AUC) of the best model was 0.904 (95% CI: 0.862-0.947), with a sensitivity and specificity of 75.5 and 90.2%, respectively.Conclusion: We have identified ten metabolite biomarkers with differentially expressed levels between elite and sub-elite swimmers, the differences could result from genetic or sports level between the two cohorts. A model with four metabolites has successfully differentiated professional swimmers with different competitive levels.
Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children
Authors: Lao Sixian , Zhou Tao , Kuo Ho-Chang , Zhong Guoping , Zeng Weiwei 
Published: May 2022

ObjectivesTo study the impact of antibiotics used in Kawasaki disease (KD) with coronary artery lesions (CAL) and identify independent risk factors.MethodologyThis study reviewed the records of 287 KD patients between the years 2016 and 2020. Patients were grouped by their outcome, the CAL group, and a no-coronary artery lesions (NCAL) group, and stratified by the use of antibiotics. We collected clinical and laboratory data before the intravenous immunoglobulin (IVIG) treatment.ResultsThe two groups of KD patients with and without CAL were compared. The results showed that there are significant differences between groups which were erythrocyte count (p = 0.045) and hemoglobin (p = 0.005), red blood cell-specific volume (p = 0.001), immature granular cells percentage (p = 0.006), total protein (p = 0.045), albumin (p = 0.041), alkaline phosphatase (p = 0.023), and chlorine (p = 0.006). After multivariate logistic regression, neutrophil granulocyte percentage (odds ratio [OR] = 1.200, 95% confidence interval [CI]: 1.008-1.428, p = 0.040), lymphocyte percentage (p = 0.028, OR = 1.243, 95% CI: 1.024-1.508, p = 0.028) and total protein (OR = 4.414, 95% CI: 1.092-17.846, p = 0.037) were found to be independent risk factors for CAL. After analyzing the cases with a history of antibiotic use, multivariate analysis showed no indicators were considered independent risk factors for CAL.ConclusionNeutrophil granulocyte percentage, Lymphocyte percentage and total protein were independent risks for CAL in KD without antibiotics use history. The use of antibiotics affected physiological indicators of KD patients.
A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults
Authors: Huang Hao 
Published: May 2022

Objective: The purpose of the study was to evaluate the anti-aging effect of NMN and its safety in a double-blind, parallel, randomised controlled clinical trial.Methods: The study was carried out on 66 healthy subjects between the ages of 40 and65 years, instructed to take two capsules (each containing 150 mg. of NMN or starch powder) once a day after breakfast for 60 days.Results: At day 30, NAD+/NADH levels in the serum showed a noteworthy increase, i.e., by 11.3%, whereas the placebo group had shown no change at all. At the end of the study, i.e., day 60, the NAD+/NADH levels were increased further by 38% compared to baseline, against a mere 14.3% in the placebo group. In the case of SF 36, at day 60, the Uthever group showed a rise of 6.5%, whereas the placebo group was merely raised by 3.4%. At the end of the study, the mean HOMA IR Index showed a rise of 0.6% among the Uthever group and 30.6% among the Placebo group from baseline.Conclusion: The rise in the levels of NAD+/NADH at day 30 and day 60 illustrated the potential of Uthever to raise the levels of NAD+ in the cells, which is linked to higher energy levels and an anti-aging effect. Increased sensitivity to insulin has also been linked to anti-aging. There was no noteworthy change in HOMA score, in the Uthever group whereas there was a noteworthy rise in the placebo group, demonstrating the anti-aging effect of Uthever as in its absence, the parameters worsened.Clinical Trial Registration: (clinicaltrials.gov), identifier (NCT04228640 NMN).
Ponencias
Authors: Autores Varios 
Published: May 2022

Durante los días miércoles 25 y jueves 26 de agosto del 2021, se realizó la décimo cuarta versión del Encuentro Departamental de Semilleros de Investigación de la Red Regional de Semilleros de Investigación -RREDSI, Nodo Quindío.
En esta nueva versión, la Universidad del Quindío lideró la organización de este tradicional encuentro departamental, el cual acogió, de manera virtual, a estudiantes de todas las instituciones de educación del Departamento, entre las que se encuentran las universidades Remington, La Gran Colombia Armenia, Alexander von Humboldt, Corporación Universitaria Unificada Nacional de Educación Superior, Antonio Nariño, Institución Universitaria EAM y el SENA.
Un total de 88 trabajos de investigación socializados en la modalidad de ponencia, las cuales fueron resultado de la interacción con comunidades y el sector productivo a partir de sus proyectos de semilleros de investigación.
Heart and Vascular Lesions in Children in the COVID-19 Era
Authors: Рубан А.П. 
Published: May 2022

Статья посвящена проблеме кардиоваскулярных нарушений у педиатрических пациентов в эпоху COVID-19. Автор дает характеристику наиболее частым вариантам поражений сердца и сосудов, ассоциированных с COVID-19, у детей. В статье обозначены возможные патогенетические механизмы и соответствующие им проявления кардиоваскулярных поражений при COVID-19. Автором представлены основные алгоритмы диагностического поиска, а также подходы к профилактике осложнений коронавирусной инфекции со стороны сердечно-сосудистой системы. Перечислены ургентные кардиологические состояния и обозначены подходы к их коррекции. В материале сделан акцент на практических моментах, основанных на собственных клинических наблюдениях. Продемонстрированы результаты инструментальных исследований при различных вариантах кардиоваскулярных поражений. Автор обобщает отечественную нормативную документацию по ведению пациентов с COVID-19.
The article is devoted to the problem of cardiovascular disorders in pediatric patients in the era of COVID-19. The author characterizes the most frequent variants of heart and vascular lesions in children associated with COVID-19. Possible pathogenetic mechanisms and their corresponding manifestations of cardiovascular lesions in COVID-19 are outlined in the article. The author presents the main algorithms of diagnostic search, as well as approaches to the prevention of cardiovascular complications of coronavirus infection. Urgent cardiac conditions are listed and approaches to their correction are outlined. The article focuses on practical points based on our own clinical observations. The results of instrumental investigations for different variants of cardiovascular lesions are demonstrated. The author summarizes national regulatory documentation on the management of patients with COVID-19.
The Effectiveness of Medical Rehabilitation in Older People with Bronchial Asthma after Pneumonia COVID-19
Authors: Оленская Т.Л. , Азаренок М.К. , Кокойченко А.А. , Николаева А.Г. 
Published: May 2022

В работе представлены результаты исследования пациентов старшего возраста с бронхиальной астмой и различным уровнем физической активности после перенесенной пневмонии, ассоциированной с инфекцией COVID-19, после программы медицинской реабилитации.С учетом полученных результатов показана рациональность применения для данной категории пациентов предложенных компонентов на амбулаторном этапе медицинской реабилитации.
The paper presents the results of a study of older patients with bronchial asthma and various levels of physical activity after suffering pneumonia associated with COVID-19 infection after a medical rehabilitation program.Taking into account the results obtained, the rationality of using the proposed components for this category of patients at the outpatient stage of medical rehabilitation is shown.