bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of tailored residual stress on micro end milling: numerical modelling and validation
Authors: Yadav Rahul , Chakladar Nilanjan Das , Paul Soumitra 
Published: October 2022

Abstract
Precision components often require micro-milling, where burrs may occur as surface defects. Such defects are likely to be influenced by the stress state in the raw material prior to micro-milling. A pre-treatment on the surface is found to compensate for the formation of burrs and improve the finishing of the micro-milled component. A finite element model of the micro-milling process was developed in Abaqus. An enhanced flow algorithm based on strain-gradient and dynamic recrystallization was used, along with a tool/workpiece friction model. This study revealed that compressive residual stress of about 613 MPa in Ti-6Al-4V can lower burr formation by up to 60%, cutting temperatures by 7% and contact forces by 15%. Additionally, surface residual stresses induced by micro-milling are predicted for compressively pre-stressed and as-received samples. The mechanism of burr formation, cutting forces, and cut marks on the sidewall surface were reported. The simulated burr morphology, chip contact length, cutting forces and surface residual stresses after micro-milling were verified with experimental results.
A pragmatic approach for assessing risk of arsenic in water–soil–plant-human continuum in an arsenic endemic area (Nadia) of West Bengal, India
Authors: Mishra Rahul , Datta Siba Prasad , Golui Debasis , Meena Mahesh Chand , Dwivedi Brahma Swaroop , Bandyopadhyay Kali Kinkar , Bhatia Arti , Rahman Mohammad Mahmudur , Roy Arkaprava , Pandey Punyavrat S 
Published: October 2022

Abstract

A pragmatic approach has been chosen to assess the risk of arsenic (As) in the water-soil-plant-human continuum in an arsenic-prone area of Nadia district in West Bengal. Arsenic is a dangerous carcinogen, and people’s exposure to As via rice consumption is widely recognized. For this purpose, 201 paired soil and rice grain samples were collected from the main rice-producing agricultural field in West Bengal and analysed for their pH levels, organic carbon, extractable As, and As content in rice grain. Olsen extractable As concentration varied from 0.48 to 3.57 mg kg− 1 with a mean value of 1.45 mg kg− 1. Rice grain samples contained As in the 0.20 to 0.61 mg kg-1 range while the mean value was 0.43 mg kg− 1. The hazard quotient for As intake via human consumption is due to the rice grain varying between 0.27 to 0.83. Lifetime cancer risks related to As intake through drinking water and dermal intake were 1.0 × 10− 3 and 4.23× 10− 5, respectively, yielding a cumulative value for an overall lifetime cancer risk ranging from 5.70 × 10 − 4 to 4.10 × 10− 3 with a mean value of 1.09 × 10− 3. Solubility-free ion activity model (FIAM) could explain up to 75% variation in As concentration in rice grain. This model has been successfully validated in half of the data set for its future use for the first time. A ready reckoner was developed based on FIAM to define toxic limits of extractable As in soil with reference to pH, OC, and grain As content.
Live-Attenuated Measles, Mumps and Rubella (MMR) and Varicella Zoster Virus (VZV) Vaccines Are Safe in Pediatric Patients with Juvenile Idiopathic Arthritis (JIA) Treated with Biologics
Authors: Herrera Michelle , Lowe Robert , Lellis-Petrie Sophie 
Published: October 2022

Abstract
Juvenile Idiopathic Arthritis (JIA) broadly refers to a group of heterogenous diseases that share the common feature of chronic inflammatory arthritis of unknown cause lasting longer than 6 weeks with onset before 16 years of age [3]. Patients with autoimmune diseases such as JIA remain under-vaccinated due to hypothetical concern for infection development. However, it is crucial for these patients to be protected against vaccine-preventable illnesses due to their underlying immune dysfunction as well as the various immunomodulatory drugs that are used in its treatment. Current recommendations are out of date, as they clearly advise physicians to avoid giving these important vaccinations due to unsupported concerns that they are putting patients at risk of preventable death from infection arising from live vaccines. We performed a retrospective chart review and obtained data from patients via phone survey. Our results showed that the use of live-attenuated MMR and VZV vaccines is safe in pediatric patients with JIA being treated with biologics, as there were no serious adverse events reported.
PHB2 Promotes Colorectal Cancer Cell Proliferation and Tumorigenesis through NDUFS1-mediated Oxidative Phosphorylation
Authors: ren lin , Meng Li , Gao Jing , Lu Mingdian , Guo Chengyu , Li Yunyun , Rong Ziye , Ye Yan 
Published: October 2022

Abstract
The alteration of cellular energy metabolism is a hallmark of colorectal cancer (CRC). Accumulating evidence has suggested oxidative phosphorylation (OXPHOS) is upregulated to meet the demand for energy in tumor initiation and development. However, the role of OXPHOS and its regulatory mechanism in CRC tumorigenesis and progression remain unclear. Here, we reveal that Prohibitin 2 (PHB2) expression is elevated in precancerous adenomas and CRC, which promotes cell proliferation and tumorigenesis of CRC. Additionally, knockdown of PHB2 significantly reduces mitochondrial OXPHOS levels in CRC cells. Meanwhile, NADH:ubiquinone oxidoreductase core subunit S1 (NDUFS1), as a PHB2 binding partner, is screened and identified by co-immunoprecipitation and mass spectrometry. Furthermore, PHB2 directly interacts with NDUFS1 and they co-localize in mitochondria, which facilitates NDUFS1 binding to NADH:ubiquinone oxidoreductase core subunit V1 (NDUFV1), regulating the activity of complex Ⅰ. Consistently, partial inhibition of complex Ⅰ activity also abrogates the increased cell proliferation induced by overexpression of PHB2 in normal human intestinal epithelial cells and CRC cells. Collectively, these results indicate that increased PHB2 directly interacts with NDUFS1 to stabilize mitochondrial complex Ⅰ and enhance its activity, leading to upregulated OXPHOS levels, thereby promoting cell proliferation and tumorigenesis of CRC. Our findings provide a new perspective for understanding of CRC energy metabolism, as well as novel intervention strategies for CRC therapeutics.
The potential of adding mammography to HHUS and ABUS to reduce unnecessary biopsies in BI-RADS ultrasound category 4a: a multicenter hospital-based study in China
Authors: Ren Wenhui , Zhao Xuelian , Zhao Xiaowei , Yan Huijiao , Hu Shangying , Qiao Youlin , Xu Zhijian , Zhao Fanghui 
Published: October 2022

Abstract
Purpose
This study compares image features influencing false-positive lesions in category 4a between handheld ultrasound (HHUS) and automated breast ultrasound (ABUS) and explores the role of second-look mammography (MAM) adjunct to US of 4a masses.
Methods
Women aged 30 to 69 underwent HHUS and ABUS from 2016 through 2017 at five high-level hospitals in China with those aged 40 or older also accepting MAM. Logistic regression analysis assessed image variables correlated with false-positive lesions in US category 4a. Unnecessary biopsies, invasive cancer (IC) yields, and diagnostic performance among different biopsy thresholds were compared.
Results
1946 women (44.9±9.8 years) were eligible for analysis. 188 (9.66%) were categorized as category 4a in HHUS and 117 (6.01%) of ABUS. Orientation, architectural distortion, and duct change were independent factors associated with the false-positive lesions in 4a of HHUS, whereas premenopausal, size, calcification, and architectural distortion were significant features of ABUS (all P＜0.05). For HHUS, both unnecessary biopsy rate and IC yields were significantly reduced when changing biopsy thresholds by adding MAM for US 4a patients (scenario #1:BI-RADS 3, 4, and 5; scenario #2: BI-RADS 4 and 5) compared with the current scenario (all P＜0.05). However, scenario #1 reduced false-positive biopsies without affecting IC yields when compared to the current scenario for ABUS (P＜0.001; P=0.125).
Conclusions
The higher unnecessary biopsy rate of category 4a by ABUS was similar to HHUS. However, the second-look MAM adjunct to ABUS has the potential to safely reduce false-positive biopsies.
Molecular structure and characteristics of phytoglycogen, glycogen and amylopectin subjected to mild acid hydrolysis
Authors: Miao Ming , Pan Bo , Li Yungao , Hamaker Bruce 
Published: October 2022

Abstract
The structure and properties of phytoglycogen and glycogen subjected to acid hydrolysis was investigated using amylopectin as a reference. The degradation took place in two stages and the degree of hydrolysis was in the following order: amylopectin > phytoglycogen > glycogen. Upon acid hydrolysis, molar mass distribution of phytoglycogen or glycogen gradually shifted to the smaller and broadening distribution region, whereas the distribution of amyopectin changed from bimodal to monomodal shape. The kinetic rate constant for depolymerization of phytoglycogen, amylopectin and glycogen were 3.45×10− 5, 6.13×10− 5 and 0.96×10− 5 s− 1, respectively. The acid-treated sample had the smaller particle size, lower percentage of α-1,6 linkage as well as higher rapidly digestible starch fractions. The depolymerization models were built to interpret the structural differences of glucose polymer during acid treatment, which would provide guideline to improve the structure understanding and precise application of branched glucan with desired properties.
Impact of the COVID-19 pandemic: Effects of High Intensity Exercise on Physiological Indicators of Recovery Period by Wearing Face Masks of Elite Athletes
Authors: Kwon Hyeong-Tae , Kim Do-Youn , Kim Daeho 
Published: October 2022

Abstract
Background
Athletes need to maintain the necessary physical conditioning for sports performance with wearing face masks to reduce the risk of virus transmission during training and competition during the COVID-19 situation. The quantitative and physiological (i.e., heart rate, PRE, lactate) effects of face masks on exercise capacity needs to be reported. The purpose of this study was to evaluate elite athletes’ sports performance and body composition during the COVID-19 in 2020, and to quantify in detail the effect of KF94 on changes in lactic acid during recovery after high-intensity aerobic exercise.
Methods
The 13 athletes who participated in December 2019 and December 2020 were surveyed and matched by age, gender, and sports categories to evaluate their body composition and sports performance (lower limb strength test, anaerobic power test). In addition, a crossover design was used to examine the effects of using a disposable KF94 face mask during exercise.
Results
The 2020 group (16.29 ± 3.25 kg) was lower in the leg muscle mass than the 2019 group (16.72 ± 3.24 kg). The right knee extensor strength (p = 0.005) and power (p = 0.003) were lower in the 2020 group’s isokinetic muscle function than in the 2019 group. In the Wingate anaerobic test, peak power (p = 0.001) and average power (p = 0.006) of the 2020 group were also lower than those of the 2019 group. Resting state blood lactate level were 1.35 ± 0.14mM/L without a mask, 2.50 ± 0.49mM/L with an KF94 mask (p < 0.001). Also, the lactic acid concentration at 20 minutes of recovery after maximum exercise was 5.98 ± 1.53mM/L without a mask, 7.61 ± 1.85mM/L with an KF94 mask (p < 0.001). However, there was no statistical differences in blood lactate concentrations immediately after exercise (p = 0.407), at 5 (p = 0.671) and 10 minutes (p = 0.313) of recovery. The rate of lactic acid removal in the post-exercise recovery period were 53.56 ± 6.77 (%) without a mask, 45.5 ± 9.9 (%) with a KF94 mask (p < 0.001). The maximum laps of shuttle run tests were 101.5 ± 22.5 laps without a mask, 94.2 ± 20.2 laps with a KF94 mask (p < 0.001). However, changes in maximum heart rate and post-exercise recovery heart rate showed no statistical difference regardless of the mask (p = 0.118).
Conclusions
The main results of the study show that anaerobic peak power, average power, and extensor muscles of the lower-limb were significantly lower than before the COVID-19 situation by wearing masks in training and normal daily living, and the KF94 mask-wearing group had lower performance in high-intensity aerobic exercise and recovery rate than non-mask group.
Long-term survival and immune reconstitution of chimeric antigen receptor T-cell therapy for childhood molecular relapse of B-cell acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation
Authors: leping zhang , guanhua hu , yingxi zuo , yingjun chang , xiangyu zhao , pan suo , yueping jia , aidong lu , yu wang , chenhua yan , yu wang , lanping xu , xiaohui zhang , kaiyan liu , yifei cheng , Huang Xiao-Jun 
Published: October 2022

Abstract
Measurable residual disease (MRD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an independent risk factor for relapse in patients with acute lymphoblastic leukemia (ALL). This study aimed to assess the efficacy, safety, and immune reconstitution of chimeric antigen receptor T-cell (CAR-T) therapy in patients with molecular relapse after allo-HSCT. Eleven patients with molecular relapse of B-cell-ALL who underwent CAR-T therapy after allo-HSCT were enrolled. The rate of MRD negativity after a month of CAR-T infusion was 81.8%. Patients who bridged to second-HSCT after CAR-T therapy (n = 3) showed a trend of higher 3-year leukemia-free survival and 3-year overall survival than those who did not (n = 8; 100% vs. 75.0%; 95% CI, 45.0–104.9%; P = 0.370). No treatment-related mortalities were observed. Among patients who did not bridge to second-HSCT and remained in complete remission until the last follow-up (n = 6), five of them had not recovered normal immunoglobulin concentrations with a median follow-up of 43 months. CAR-T therapy may be a safe and effective treatment strategy to improve survival after allo-HSCT; however, the problem of prolonged hypogammaglobulinemia in patients who do not bridge to second-HSCT is worth noting.
The roles of the dietitian in an 18-week telephone and mobile application nutrition intervention for upper gastrointestinal cancer: a qualitative analysis
Authors: Testa Sharni , Furness Kate , Choi Tammie , Haines Terry , Huggins Catherine E. 
Published: October 2022

Abstract
Purpose This study aimed to explore the patient-dietitian experience during an 18-week nutrition counselling intervention delivered using the telephone and a mobile app to people newly diagnosed with upper gastrointestinal (UGI) cancer to 1) elucidate the roles of the dietitian during intervention delivery and 2) explore unmet needs impacting nutritional intake.
Methods Qualitative case study methodology was followed, whereby the case was the 18-week nutrition counselling intervention. Dietary counselling conversations and post-intervention interviews were inductively coded from six case participants which included: fifty-one telephone conversations (17 hours), 244 written messages and four interviews. Data were coded inductively, and themes constructed. The coding framework was subsequently applied to all post-study interviews (n=20) to explore unmet needs.
Results Themes describing the roles of the dietitian were: regular collaborative problem solving to encourage empowerment, a reassuring care navigator including anticipatory guidance, and rapport building via psychosocial support. Psychosocial support included provision of empathy, reliable care provision and delivery of positive perspective. Despite intensive counselling from the dietitian, nutrition impact symptom management was a core unmet need as it required intervention beyond the scope of practice for the dietitian.
ConclusionDelivery of nutrition care via the telephone or an asynchronous mobile app to people with newly diagnosed UGI cancer required the dietitian to adopt a range of roles to influence nutritional intake: they empower people, act as care navigators, and provide psychological support. Limitations in dietitians’ scope of practice identified unmet patient’s needs in nutrition impact symptom management, which requires medication management.
Trial Registration 27th January 2017 Australian and New Zealand Clinical Trial Registry (ACTRN12617000152325).
Longstanding overt ventriculomegaly diagnosed in adolescents, not adults: a pediatric case report
Authors: Ohashi Eri , Hayakawa Itaru , Usami Kenichi , Ogiwara Hideki , Abe Yuichi 
Published: October 2022

Abstract
Background
Longstanding overt ventriculomegaly in adults (LOVA) is a new form of progressive hydrocephalus characterized by onset in early childhood and gradual progression into adulthood. Patients with LOVA are usually asymptomatic in childhood. The diagnosis of LOVA in adolescence has not been reported.
Case report
A patient with macrocephaly and mild ventriculomegaly from infancy developed headache exacerbation and cognitive dysfunction at the age of 11 years. Brain magnetic resonance imaging showed mild tri-ventriculomegaly with no radiological aggravation compared to imaging at the age of 8 years. No papilledema was observed. Drainage of 15 ml of spinal fluid via a lumbar puncture relieved the headache and cognitive dysfunction. Based on repeated improvements in cognitive function and headaches after spinal fluid drainage, we diagnosed the patient with LOVA with symptom onset in early adolescence. A ventriculoperitoneal shunt was placed, and the headaches disappeared completely. The full-scale intellectual quotient, verbal comprehension, and working memory improved significantly.
Conclusions
LOVA may manifest as early as adolescence. The clinical presentation, age, clinical, radiological features, and management vary, and a spinal tap exam is useful for diagnosing LOVA, even in children. The spinal tap exam may be indicated in children with longstanding ventriculomegaly and neurological symptoms to diagnose this “treatable intellectual disability.”
Seismic resilience assessment of buildings: case study of Blida city
Authors: Yousfi Nacim , Mounir Ait Belkacem , Boukri Mehdi , Guessoum Nabila , Bensaibi Mahmoud 
Published: October 2022

Abstract

Several studies have been carried out to assess the building’s seismic vulnerability, in order to mitigate the seismic risk in urban areas, which is one of the most devastating natural hazards causing considerable economic and human losses. These studies must be incorporated to improve the planning of urban areas in order to have resistant and resilient cities in case of disasters. The seismic feedback has shown that the build back better concept has a direct impact on the city’s economic growth. In this paper, the existing buildings resilience is assessed, in order to highlight the capacity of these last to keep the functionality when an earthquake occurs. This building’s resilience has been determined according to the damages states, the reconstruction time and the reconstruction cost for three types of structures: masonry, reinforced concrete and steel. The vulnerability curves used give the damage grade according to the vulnerability index and the seismic intensity. A seismic resilience scenario was performed using a geographic information system (GIS) and applied for the Blida city (Algeria) classified as a high seismic zone according to Algerian seismic regulations.
A retrospective cohort study of pharmacogenetics of warfarin dosing in Chinese Adults with nonvalvular atrial fibrillation
Authors: Zhu Ye , You Jia , Gu Xiang , Zhu Hua , Liu Jia 
Published: October 2022

Abstract
Background: The guide for the use of genotype-guided warfarin dosing in patients for the treatment of non-valvular atrial fbrillation (NVAF) is still lacking.
Aim: We aimed to evaluate whether genotype-guided warfarin dosing is superior to conventional clinical dosing for the outcomes of interest in Chinese patients.
Method: The patients of this study were assigned to two cohorts to receive their dose of warfarin determined by a genetic and clinical factor (gene group) or dosing determined empirically(control group).We incorporated CYP2C9 and VKORC1 genotypes into the gene group. The international normalized ratio (INR) measurement and standard protocols were used for further dose adjustment in both groups. The primary outcomes were the percentage of time in the therapeutic range (%TTR) and INR measurement during follow up. Secondary safety outcome included bleeding and thrombotic events.
Results: Compared with the control group, the average TTR of the gene group was higher(68.4 ± 20.6) % vs (48.5 ± 21.6) %, P<0.001) .The frequency of the average INR monitoring times of the gene group was lower(P=0.02).At the end of follow-up, the gene group had a significant lower risk of cumulative incidences of ischemic stroke events in the adjusted model [relative risk (RR) 0.4 (95% CI 0.2 to 0.8),P =0.008] than control group.
Conclusion: Genotype-guided warfarin administration increases the average TTR, reach higher TTR levels in the early anticoagulant phase and significantly reduce the risk of ischemic stroke events.
No-Dose Photodynamic Therapy Against half-dose Photodynamic Therapy for Treatment of Central Serous Chorioretinopathy
Authors: Servillo Andrea , Sacconi Riccardo , Zucchiatti Ilaria , Grachova Elena , Querques Lea , Prascina Francesco , Tombolini Beatrice , Dorin Giorgio , Mainster Martin , Bandello Francesco , Querques Giuseppe 
Published: October 2022

Abstract
Objective
To describe the effects of no-dose full fluence photodynamic therapy without verteporfin (no-dose PDT) and to compare no-dose PDT with half-dose verteporfin full-fluence photodynamic therapy (HDFF PDT) for managing chronic central serous chorioretinopathy (cCSC).
Methods
This retrospective study evaluated 11 patients with chronic recurrent CSC treated with no-dose PDT between January 2019 and March 2022. Most of these patients were also treated with half-dose full-fluence PDT (HDFF PDT) a minimum of 3- months before and were considered as control group. We described the changes of best-corrected visual acuity (BCVA), maximum subretinal fluid (mSRF), foveal subretinal fluid (fSRF) and choroidal thickness (CT) 8 ± 2 weeks after no-dose PDT, and we compared BVCA, mSRF, fSRF and CT of no-dose PDT with those of the of same patients previously treated with HDFF PDT.
Results
Fifteen eyes of 11 patients (10 males, mean age 54 ± 12 years) received no-dose PDT; among these, 10 eyes of 8 patients (7 males, mean age 53 ± 12 years) received also HDFF PDT. Three eyes showed complete resolution of fSRF after no-dose PDT. No significant differences were disclosed between treatment with and without verteporfin comparing BCVA, mSRF, fSRF, and CT at the baseline and 8 ± 2 weeks from the treatment (p > 0.05 in all analyses).
Conclusion
BVCA and CT significantly improved after no-dose PDT. Short-term functional and anatomical treatment outcomes for cCSC were similar for HDFF PDT and no-dose PDT. We hypothesize that the potential benefits of no-dose PDT may arise thermal elevation triggers and enhances photochemical activities by endogenous fluorophores that activates a biochemical cascade response that rescues / replaces sick, dysfunctional RPE cells. Results of this study suggest the potential value of a prospective clinical trial to evaluate no-dose PDT for managing cCSC, especially when verteporfin is contraindicated or unavailable.