bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eligibility criteria for pediatric patients who may benefit from anti SARS-CoV-2 monoclonal antibody therapy administration: an Italian inter-society consensus statement
Authors: Lanari Marcello , Venturini Elisabetta , Pierantoni Luca , Stera Giacomo , Castelli Gattinara Guido , Esposito Susanna Maria Roberta , Favilli Silvia , Franzoni Emilio , Fusco Eleonora , Lionetti Paolo , Maffeis Claudio , Marseglia Gianluigi , Massella Laura , Midulla Fabio , Zanobini Alberto , Zecca Marco , Villani Alberto , Staiano Annamaria , Galli Luisa ,   Other Collaborators, Blasi Francesco , Di Giorgio Angelo , Donà Daniele , Licari Amelia , Martinelli Massimo , Mastrangelo Antonio , Miraglia del Giudice Michele , Nicolini Giangiacomo , Pugliese Fabrizio , Striano Pasquale , Valerio Giuliana 
Published: January 2022

AbstractThe fast diffusion of the SARS-CoV-2 pandemic have called for an equally rapid evolution of the therapeutic options.The Human recombinant monoclonal antibodies (mAbs) have recently been approved by the Food and Drug Administration (FDA) and by the Italian Medicines Agency (AIFA) in subjects aged ≥12 with SARS-CoV-2 infection and specific risk factors.Currently the indications are specific for the use of two different mAbs combination: Bamlanivimab+Etesevimab (produced by Eli Lilly) and Casirivimab+Imdevimab (produced by Regeneron).These drugs have shown favorable effects in adult patients in the initial phase of infection, whereas to date few data are available on their use in children.AIFA criteria derived from the existing literature which reports an increased risk of severe COVID-19 in children with comorbidities. However, the studies analyzing the determinants for progression to severe disease are mainly monocentric, with limited numbers and reporting mostly generic risk categories.Thus, the Italian Society of Pediatrics invited its affiliated Scientific Societies to produce a Consensus document based on the revision of the criteria proposed by AIFA in light of the most recent literature and experts’ agreement.This Consensus tries to detail which patients actually have the risk to develop severe disease, analyzing the most common comorbidities in children, in order to detail the indications for mAbs administration and to guide the clinicians in identifying eligible patients.
Effects of deworming medication on anaemia among children aged 6–59 months in sub-Saharan Africa
Authors: Bauleni Andy , Tiruneh Fentanesh N. , Mwenyenkulu Tisungane E. , Nkoka Owen , Chirwa Gowokani C. , Gowelo Steve , Chipeta Michael G. , Ntenda Peter A. M. 
Published: January 2022

AbstractBackgroundDespite the limited knowledge regarding the effects of deworming medication (DM) on nutritional indicators in sub-Saharan Africa (SSA), deworming programmes continue to be implemented in resource-limited countries. Therefore, the current study aimed to examine the effects of DM on anaemia among children aged 6–59 months in SSA.MethodsThe analysis was performed using data obtained from 17 demographic and health surveys (DHSs) conducted in SSA. Children were considered to be anaemic if their haemoglobin (Hb) concentration was less than 11.0 g/dl, adjusting for altitude. To account for both multiple measures at the cluster level and the clustering of children within the same country, generalized linear mixed models were used to analyse the anaemia outcomes in 50,075 children aged 6–59 months.ResultsOverall, anaemia was reported in 61.8% of the children, and their median Hb concentration was 10.5 g/dl (interquartile range 9.4–11.5). The prevalence of anaemia ranged from 34.5% in Rwanda to 81.1% in Mali. Multivariate analyses showed that children who did not receive DM had increased odds of being anaemic (adjusted odds ratio [aOR]: 1.11; 95% confidence interval [CI] 1.07–1.16).ConclusionsThe current study revealed that DM can decrease the risk of anaemia among preschool-age children (pre-SAC) in SSA. Thus, tailored public health programmes aimed at reducing childhood anaemia need to consider deworming. However, longitudinal studies are needed to validate the association that has been reported in this cross-sectional study.Graphical Abstract
Long-term glycemic variability and risk of stroke in patients with diabetes: a meta-analysis
Authors: Ren Xiaoli , Wang Zhiyun , Guo Congfang 
Published: January 2022

Abstract
Objectives
Long-term glycemic variability has been related to increased risk of vascular complication in patients with diabetes. However, the association between parameters of long-term glycemic variability and risk of stroke remains not fully determined. We performed a meta-analysis to systematically evaluate the above association.

Methods
Medline, Embase, and Web of Science databases were searched for longitudinal follow-up studies comparing the incidence of stroke in diabetic patients with higher or lower long-term glycemic variability. A random-effect model incorporating the potential heterogeneity among the included studies were used to pool the results.

Results
Seven follow-up studies with 725,784 diabetic patients were included, and 98% of them were with type 2 diabetes mellitus (T2DM). The mean follow-up duration was 7.7 years. Pooled results showed that compared to those with lowest category of glycemic variability, diabetic patients with the highest patients had significantly increased risk of stroke, as evidenced by glycemic variability analyzed by fasting plasma glucose coefficient of variation (FPG-CV: risk ratio [RR] = 1.24, 95% confidence interval [CI] 1.11 to 1.39, P < 0.001; I2 = 53%), standard deviation of FPG (FPG-SD: RR = 1.16, 95% CI 1.02 to 1.31, P = 0.02; I2 = 74%), HbA1c coefficient of variation (HbA1c-CV: RR = 1.88, 95% CI 1.61 to 2.19 P < 0.001; I2 = 0%), and standard deviation of HbA1c (HbA1c-SD: RR = 1.73, 95% CI 1.49 to 2.00, P < 0.001; I2 = 0%).

Conclusions
Long-term glycemic variability is associated with higher risk of stroke in T2DM patients.
Bovine respiratory microbiota of feedlot cattle and its association with disease
Authors: Chai Jianmin , Capik Sarah F. , Kegley Beth , Richeson John T. , Powell Jeremy G. , Zhao Jiangchao 
Published: January 2022

AbstractBovine respiratory disease (BRD), as one of the most common and costly diseases in the beef cattle industry, has significant adverse impacts on global food security and the economic stability of the industry. The bovine respiratory microbiome is strongly associated with health and disease and may provide insights for alternative therapy when treating BRD. The niche-specific microbiome communities that colonize the inter-surface of the upper and the lower respiratory tract consist of a dynamic and complex ecological system. The correlation between the disequilibrium in the respiratory ecosystem and BRD has become a hot research topic. Hence, we summarize the pathogenesis and clinical signs of BRD and the alteration of the respiratory microbiota. Current research techniques and the biogeography of the microbiome in the healthy respiratory tract are also reviewed. We discuss the process of resident microbiota and pathogen colonization as well as the host immune response. Although associations between the microbiota and BRD have been revealed to some extent, interpreting the development of BRD in relation to respiratory microbial dysbiosis will likely be the direction for upcoming studies, which will allow us to better understand the importance of the airway microbiome and its contributions to animal health and performance.
Refugee-led socio-spatial organization in Al Baqa’a camp, Jordan
Authors: Aburamadan Rania 
Published: January 2022

AbstractThe increase in refugee numbers is an increasingly important concern globally. Many countries in different regions have been accommodating refugees by providing temporary shelters made from ineffective and inadequate materials to provide thermal comfort for refugees. However, the shelters provided are often inadequate solutions for shelter and neglect the social and cultural diversity of the refugees. Socio-cultural norms, practices and values are rarely considered in the design of shelters and this has an adverse impact on how refugees live in these spaces. Using insights from the Al Baqa’a refugee camp in Jordan as a case study, this paper uses a mixed-method approach to explore how the challenges of inadequate shelter has consequently led refugees to self-organize and create new socio-cultural spaces to adapt to the place. The findings suggest that historically, Al Baqa’a camp has reorganized by users due to social needs and climate challenges. When the camp was created in 1967, the inadequacy of the housing and infrastructure to provide comfort influenced refugees to self-organize and create adaptive spaces of comfort. However, over the decades, these spaces have evolved into spaces of enterprise, belonging and memory of their homeland. Therefore, this paper argues that refugee shelter design should have an integrated consideration of the climatic elements and the social and cultural aspects of refugees. The paper concludes with lessons learned drawn from the evidence to act as guideline for the consideration of official humanitarian organizations in other camps and local communities.
Millennial-scale oscillations in the Kuroshio–Oyashio boundary during MIS 19 based on the radiolarian record from the Chiba composite section, central Japan
Authors: Itaki Takuya , Utsuki Sakura , Haneda Yuki , Izumi Kentaro , Kubota Yoshimi , Suganuma Yusuke , Okada Makoto 
Published: January 2022

AbstractMarine isotope stage (MIS) 19 is considered to be the best orbital analog for the present interglacial. Consequently, clarifying the climatic features of this period can provide us with insights regarding a natural baseline for assessing future climate changes. A high-resolution radiolarian record from 800 to 750 ka (MIS 20 to MIS 18) was examined from the Chiba composite section (CbCS) of the Kokumoto Formation, including the Global Boundary Stratotype Section and Point for the lower–middle Pleistocene boundary on the Boso Peninsula on the Pacific side of central Japan. Millennial-scale oscillations in the Kuroshio warm and Oyashio cold currents were revealed by the Tr index, which is estimated using a simple equation based on radiolarian assemblages. The estimated Tr values ranged between 0.1 and 0.8 for MIS 18 through MIS 19, with minimum and maximum values corresponding to values observed off present day Aomori (41°N) and the Boso Peninsula (35°N), respectively. The observed patterns tended to be synchronous with the total radiolarian abundance associated with their production. Multiple maxima in radiolarian abundance occurred during periods of the Oyashio expanded mode before 785 ka and during periods of Kuroshio extension after 785 ka in MIS 19. Such increases in radiolarian abundance with the Kuroshio extension during MIS 19 are likely related to improvements in nutrient and photic environments with the development of a two-layer structure along the Kuroshio–Oyashio boundary zone. A similar pattern of millennial-scale climatic changes was also recognized in a precipitation record from the Sulmona Basin in central Italy, suggesting a close relationship with the CbCS record as a result of a large-scale climate system similar to the Arctic Oscillation in the northern hemisphere.
Clinical outcomes of surgical management for rare types of progressive familial intrahepatic cholestasis: a case series
Authors: Masahata Kazunori , Ueno Takehisa , Bessho Kazuhiko , Kodama Tasuku , Tsukada Ryo , Saka Ryuta , Tazuke Yuko , Miyagawa Shuji , Okuyama Hiroomi 
Published: January 2022

Abstract
Background
Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of genetic autosomal recessive diseases that cause severe cholestasis, which progresses to cirrhosis and liver failure, in infancy or early childhood. We herein report the clinical outcomes of surgical management in patients with four types of PFIC.

Case presentation
Six patients diagnosed with PFIC who underwent surgical treatment between 1998 and 2020 at our institution were retrospectively assessed. Living-donor liver transplantation (LDLT) was performed in 5 patients with PFIC. The median age at LDLT was 4.8 (range: 1.9–11.4) years. One patient each with familial intrahepatic cholestasis 1 (FIC1) deficiency and bile salt export pump (BSEP) deficiency died after LDLT, and the four remaining patients, one each with deficiency of FIC1, BSEP, multidrug resistance protein 3 (MDR3), and tight junction protein 2 (TJP2), survived. One FIC1 deficiency recipient underwent LDLT secondary to deterioration of liver function, following infectious enteritis. Although he underwent LDLT accompanied by total external biliary diversion, the patient died because of PFIC-related complications. The other patient with FIC1 deficiency had intractable pruritus and underwent partial internal biliary diversion (PIBD) at 9.8 years of age, pruritus largely resolved after PIBD. One BSEP deficiency recipient, who had severe graft damage, experienced recurrence of cholestasis due to the development of antibodies against BSEP after LDLT, and eventually died due to graft failure. The other patient with BSEP deficiency recovered well after LDLT and there was no evidence of posttransplant recurrence of cholestasis. In contrast, recipients with MDR3 or TJP2 deficiency showed good courses and outcomes after LDLT.

Conclusions
Although LDLT was considered an effective treatment for PFIC, the clinical courses and outcomes after LDLT were still inadequate in patients with FIC1 and BSEP deficiency. LDLT accompanied by total biliary diversion may not be as effective for patients with FIC1 deficiency.
Analysis of the cryptocurrency market using different prototype-based clustering techniques
Authors: Lorenzo Luis , Arroyo Javier 
Published: January 2022

AbstractSince the emergence of Bitcoin, cryptocurrencies have grown significantly, not only in terms of capitalization but also in number. Consequently, the cryptocurrency market can be a conducive arena for investors, as it offers many opportunities. However, it is difficult to understand. This study aims to describe, summarize, and segment the main trends of the entire cryptocurrency market in 2018, using data analysis tools. Accordingly, we propose a new clustering-based methodology that provides complementary views of the financial behavior of cryptocurrencies, and one that looks for associations between the clustering results, and other factors that are not involved in clustering. Particularly, the methodology involves applying three different partitional clustering algorithms, where each of them use a different representation for cryptocurrencies, namely, yearly mean, and standard deviation of the returns, distribution of returns that have not been applied to financial markets previously, and the time series of returns. Because each representation provides a different outlook of the market, we also examine the integration of the three clustering results, to obtain a fine-grained analysis of the main trends of the market. In conclusion, we analyze the association of the clustering results with other descriptive features of cryptocurrencies, including the age, technological attributes, and financial ratios derived from them. This will help to enhance the profiling of the clusters with additional descriptive insights, and to find associations with other variables. Consequently, this study describes the whole market based on graphical information, and a scalable methodology that can be reproduced by investors who want to understand the main trends in the market quickly, and those that look for cryptocurrencies with different financial performance.In our analysis of the 2018 and 2019 for extended period, we found that the market can be typically segmented in few clusters (five or less), and even considering the intersections, the 6 more populations account for 75% of the market. Regarding the associations between the clusters and descriptive features, we find associations between some clusters with volume, market capitalization, and some financial ratios, which could be explored in future research.
Energy crypto currencies and leading U.S. energy stock prices: are Fibonacci retracements profitable?
Authors: Gurrib Ikhlaas , Nourani Mohammad , Bhaskaran Rajesh Kumar 
Published: January 2022

AbstractThis paper investigates the role of Fibonacci retracements levels, a popular technical analysis indicator, in predicting stock prices of leading U.S. energy companies and energy cryptocurrencies. The study methodology focuses on applying Fibonacci retracements as a system compared with the buy-and-hold strategy. Daily crypto and stock prices were obtained from the Standard & Poor's composite 1500 energy index and CoinMarketCap between November 2017 and January 2020. This study also examined if the combined Fibonacci retracements and the price crossover strategy result in a higher return per unit of risk. Our findings revealed that Fibonacci retracement captures energy stock price changes better than cryptos. Furthermore, most price violations were frequent during price falls compared to price increases, supporting that the Fibonacci instrument does not capture price movements during up and downtrends, respectively. Also, fewer consecutive retracement breaks were observed when the price violations were examined 3 days before the current break. Furthermore, the Fibonacci-based strategy resulted in higher returns relative to the naïve buy-and-hold model. Finally, complementing Fibonacci with the price cross strategy did not improve the results and led to fewer or no trades for some constituents. This study’s overall findings elucidate that, despite significant drops in oil prices, speculators (traders) can implement profitable strategies when using technical analysis indicators, like the Fibonacci retracement tool, with or without price crossover rules.
Chikungunya outbreak in Bangladesh (2017): sociodemographic and clinical characteristics of patients from three hotspots
Authors: Amin Mohammad Robed , Hasan Mohammad Jahid , Khan Md. Abdullah Saeed , Rafi Md Abdur , Islam Mohammad Rafiqul , Shams Tarek , Islam Mohammed Jahedul , Kabir Abu Saif Mohammad Lutful , Sharif Mohiuddin , Gozal David 
Published: January 2022

AbstractBackgroundChikungunya is a severely debilitating disease. Bangladesh witnessed one of the largest outbreaks in 2017. Here, we described the clinical profile of the chikungunya outbreak in Bangladesh and its heterogeneity across three hotspots.MethodsThis was a descriptive cross-sectional study of 432 individuals interviewed from the outpatient department of three study sites (Dhaka, Chittagong, and Sitakundu Upazilla of Bangladesh) after confirmation by the study physicians. Both laboratory-confirmed cases and probable cases were recruited between July and October 2017.ResultsOf all, 18% (79) were laboratory confirmed, and 353 82% (335) were probable cases. The male:female ratio was almost equal (1.09:1), and the predominant age group was 18–59 years. The mean age of the presentation was 36.07 ± 13.62 (SD) years. Fever and arthralgia were the most common presentations and were present in > 95% of cases. Other frequent symptoms were fatigue, myalgia, headache, nausea, and vomiting. Approximately half of the patients had arthritis and erythematous rash. Arthritis was predominant in Chittagong city, while maculopapular rash was not observed in Sitakunda city. However, fatigue, nausea, and vomiting are more common among patients in Dhaka city. Significant heterogeneity of clinical manifestations was present across the three hotspots (p < 0.05 for all). Both confirmed and probable cases shared similar characteristics except muscle ache (p = 0.22) and rash (p = 0.37).ConclusionThe clinical profile of chikungunya virus-induced disease displays significant location-related heterogeneity in Bangladesh during a large outbreak. Although the causes of such differences are unclear, improved public and medical personnel education on this condition may lead to earlier diagnosis and treatment.
Ubiquitination in the rice blast fungus Magnaporthe oryzae: from development and pathogenicity to stress responses
Authors: Wang Yu , Yang Nan , Zheng Yunna , Yue Jiaolin , Bhadauria Vijai , Peng You-Liang , Chen Qian 
Published: January 2022

AbstractUbiquitination is a vital protein post-translational modification (PTM) prevalent in eukaryotes. This modification regulates multiple cellular processes through protein degradation mediated by the 26S proteasome or affecting protein–protein interaction and protein localization. Magnaporthe oryzae causes rice blast disease, which is one of the most devastating crop diseases worldwide. In M. oryzae, ubiquitination plays important roles in growth, pathogenicity, stress response and effector-mediated plant-pathogen interaction. In this review, we summarize the roles of ubiquitination components in the above biological processes of M. oryzae, including single- or multi-subunit E3s, E2s, components of 26S proteasome and also deubiquitinating enzymes. The essential function of ubiquitination in plant-fungus interaction is also discussed. Moreover, this review presents several issues related to the ubiquitination system in M. oryzae, which need to be further explored in future researches.
Barriers to implementation of pediatric emergency department interventions for parental tobacco use and dependence: a qualitative study using the theoretical domains framework
Authors: Merianos Ashley L. , Fiser Kayleigh A. , Mahabee-Gittens E. Melinda , Lyons Michael S. , Gordon Judith S. 
Published: January 2022

Abstract
Background
Pediatric emergency department (PED) and urgent care (UC) professionals can play a key role in delivering evidence-based guidelines to address parental tobacco use and child tobacco smoke exposure (TSE). Understanding PED/UC professionals’ perceptions regarding these guidelines is the first step in developing and implementing a TSE screening and counseling intervention in these settings. This study aimed to use the theoretical domains framework (TDF) to identify current screening and counseling behaviors of PED/UC professionals related to parental tobacco use and child TSE, and determine barriers and enablers that influence these behaviors.

Methods
Semi-structured, focused interviews were conducted with 29 actively practicing PED/UC clinical staff who worked at one large, Midwestern children’s hospital. The interview guide was informed by the TDF and included open-ended questions. Content analysis of interview transcripts was guided by the TDF. Nurses, physicians, and healthcare administrators were assessed overall and by group membership to ensure each group was represented based on their varying PED/UC roles.

Results
Fifty-one percent were nurses, 38% were physicians, and 11% were healthcare administrators. Most PED/UC professionals did not currently follow the guidelines, but perceived addressing parental tobacco use as part of their role. All 14 TDF domains were identified by nurses, physicians, and administrators in relation to counseling for parental tobacco use and child TSE. Domains with the most sub-themes were (1) knowledge: lack of knowledge about tobacco counseling, including implementing counseling, cessation resources/referrals, and thirdhand smoke; (2) beliefs about capabilities: not comfortable counseling parents, easier to discuss with parents who are receptive and to ask and advise when patients have a TSE-related complaint, and more likely to discuss if there were resources/referrals; and (3) environmental context and resources: barriers include lack of time, training, and resources and referral information to give to parents, and an enabler is using TSE-related complaints as a context to offer counseling.

Conclusions
Study findings provide a strong foundation for developing and implementing clinical practice guidelines regarding parental tobacco use and child TSE in the PED/UC setting. Future intervention development will address all TDF domains and test the implementation of the intervention in the PED/UC setting.