bluuebunny/crossref_metadata_2025_split huggingface dataset:
When the clock ticks wrong with COVID‐19
Authors: Papagerakis Silvana , Said Raed , Ketabat Farinaz , Mahmood Razi , Pundir Meenakshi , Lobanova Liubov , Guenther Greg , Pannone Giuseppe , Lavender Kerry , McAlpin Blake R. , Moreau Alain , Chen Xiongbiao , Papagerakis Petros 
Published: November 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of the coronavirus family that causes the novel coronavirus disease first diagnosed in 2019 (COVID‐19). Although many studies have been carried out in recent months to determine why the disease clinical presentations and outcomes can vary significantly from asymptomatic to severe or lethal, the underlying mechanisms are not fully understood. It is likely that unique individual characteristics can strongly influence the broad disease variability; thus, tailored diagnostic and therapeutic approaches are needed to improve clinical outcomes. The circadian clock is a critical regulatory mechanism orchestrating major physiological and pathological processes. It is generally accepted that more than half of the cell‐specific genes in any given organ are under circadian control. Although it is known that a specific role of the circadian clock is to coordinate the immune system's steady‐state function and response to infectious threats, the links between the circadian clock and SARS‐CoV‐2 infection are only now emerging. How inter‐individual variability of the circadian profile and its dysregulation may play a role in the differences noted in the COVID‐19‐related disease presentations, and outcome remains largely underinvestigated. This review summarizes the current evidence on the potential links between circadian clock dysregulation and SARS‐CoV‐2 infection susceptibility, disease presentation and progression, and clinical outcomes. Further research in this area may contribute towards novel circadian‐centred prognostic, diagnostic and therapeutic approaches for COVID‐19 in the era of precision health.
Molybdenum Alkylidyne Silyloxy N‐Heterocyclic Carbene Complexes – Highly Active Alkyne Metathesis Catalysts that can be Handled in Air
Authors: Musso Janis V. , Gramm Vincent , Stein Sarjano , Frey Wolfgang , Buchmeiser Michael R. 
Published: November 2022

AbstractA series of molybdenum alkylidyne silyloxy N‐heterocyclic carbene (NHC) complexes of the general formula [Mo(≡C(R))(OSiPh3)3(NHC)] (R=tBu, 4‐methoxyphenyl, 2,4,6‐trimethylphenyl; NHC = 1,3‐diisopropylimidazol‐2‐ylidene, 1,3‐dicyclohexylimidazol‐2‐ylidene, 1,3‐dicyclohexyl‐4,5‐dihydroimidazol‐2‐ylidene, 1,3‐dimethylimidazol‐2‐ylidene, 1,3‐dimethyl‐4,5‐dichloroimidazol‐2‐ylidene) was synthesized. Single crystal X‐ray analyses revealed that with increasing steric demand of the alkylidyne group, enhanced air‐stability of the complexes in the solid‐state is achieved with the most stable complex (R=2,4,6‐trimethylphenyl, NHC = 1,3‐diisopropylimidazol‐2‐ylidene) being stable in air for 24 h without showing signs of decomposition in 1H NMR. In contrast to previously reported air‐stable molybdenum‐based complexes, the novel catalysts proved to be highly active in alkyne metathesis, allowing for turnover numbers (TONs) of up to 6000 without further activation, and tolerant towards several functional groups such as tosyl, ether, ester, thioether and nitro moieties. Their air stability allows for facile handling of the catalysts in air and even after exposure to ambient atmosphere for one week, the most stable representative still displayed high productivity in alkyne metathesis.
Conditional hazard for simplified multi‐site seismic hazard and risk analyses
Authors: Cito Pasquale , Chioccarelli Eugenio , Iervolino Iunio 
Published: November 2022

AbstractThe joint probability distribution of different intensity measures at different sites in one earthquake is needed to define the stochastic process regulating the exceedance (in time) of the at the ensemble of the sites, which in turn is a funding element of the so‐called multi‐site probabilistic seismic hazard analysis (MSPSHA). The simplest model for the joint distribution of the in one seismic event requires the mean vector and the covariance matrix of the at all sites, conditional to the magnitude and location of the earthquake, which may need a large amount of data to be calibrated. The conditional hazard (CH) approach, originally developed for single‐site surrogate vector‐valued probabilistic seismic hazard analysis, may be a simplified option for MSPSHA, as it explicitly models only part of the covariance matrix of the at the sites, while the rest forcefully follows the working assumptions. The presented paper compares the CH approach for MSPSHA against the benchmark in which the complete covariance matrix is modelled, using a testbed in which one‐hundred sites are considered. When the comparison metric is the probability of a given number of exceedances observed at the sites in some time intervals, it is found that CH is a viable alternative to MSPSHA, although the degree of approximation is sensitive to which and how many are considered (e.g., which spectral acceleration). When the analysis is taken all the way to the risk, considering the fragilities of a portfolio of hypothetical buildings, and taking as the metric the probability of observing a given number of structural failures in a time interval, it is found that the approximation introduced by CH with respect to the benchmark is further reduced.
Is vitamin D deficiency influenced by obesity during the first 5 years of life? A cross‐sectional multicenter study
Authors: Zhao Yan , Qin Rui , Hong Hong , Lv Heyu , Ye Kan , Wei Yarong , Zheng Wen , Qi Hongxia , Ni Yufei , Zhang Li , Yang Guoqiang , Liu Guoqin , Wu Aiping 
Published: November 2022

AbstractEvidence on the association of 25‐hydroxyvitamin D (25[OH]D) and obesity during the first 5 years of life is limited in China. The objective of this study was to examine the associations between weight, weight for age z score (ZWAZ), weight for length/height z score (ZWHZ), and body mass index for age z score (ZBMI) and 25(OH)D. This was a large population‐based cross‐sectional multicenter study in which the children aged 0–5 years were recruited from 12 children's healthcare centers by a stratified cluster random‐sampling method in 10 cities of the Jiangsu province, China. The 25(OH)D concentration was determined by ELISA. A total of 5289 children were investigated. For 0–71 months children with obesity and nonobesity, the prevalence of vitamin D deficiency was 36.0% and 29.8%, and the 25(OH)D level was 59.8 and 64.0 nmol/L, respectively, and there were all significant difference. Compared with children with nonobesity, children with obesity had higher risk of vitamin D deficiency (OR [95% CI]: 1.33 [1.02, 1.72], p < .05), and had lower 25(OH)D level (β = −3.84, 95% CI = −7.58, −0.09, p < .05). The results for children aged 24–71 months were similar to those for children aged 0–71 months. However, no significant difference was observed in children aged 0–23 months. Vitamin D deficiency was observed in children with greater adiposity during the first 5 years of life. However, the results mainly came from those in the age group of 2 to 5 years instead of the first 2 years in their lives.
IGF1R expression by adult oligodendrocytes is not required in the steady‐state but supports neuroinflammation
Authors: Locatelli Giuseppe , Marques‐Ferreira Filipa , Katsoulas Antonis , Kalaitzaki Vasileia , Krueger Martin , Ingold‐Heppner Barbara , Walthert Sabrina , Sankowski Roman , Prazeres da Costa Olivia , Dolga Amalia , Huber Magdalena , Gold Maike , Culmsee Carsten , Waisman Ari , Bechmann Ingo , Milchevskaya Vladislava , Prinz Marco , Tresch Achim , Becher Burkhard , Buch Thorsten 
Published: November 2022

AbstractIn the central nervous system (CNS), insulin‐like growth factor 1 (IGF‐1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti‐apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work also suggests that IGF‐1 protects ODCs from cell death and enhances remyelination in models of toxin‐induced and autoimmune demyelination. However, since evidence remains controversial, the therapeutic potential of IGF‐1 in demyelinating CNS conditions is unclear. To finally shed light on the function of IGF1‐signaling for ODCs, we deleted insulin‐like growth factor 1 receptor (IGF1R) specifically in mature ODCs of the mouse. We found that ODC survival and myelin status were unaffected by the absence of IGF1R until 15 months of age, indicating that IGF‐1 signaling does not play a major role in post‐mitotic ODCs during homeostasis. Notably, the absence of IGF1R did neither affect ODC survival nor myelin status upon cuprizone intoxication or induction of experimental autoimmune encephalomyelitis (EAE), models for toxic and autoimmune demyelination, respectively. Surprisingly, however, the absence of IGF1R from ODCs protected against clinical neuroinflammation in the EAE model. Together, our data indicate that IGF‐1 signaling is not required for the function and survival of mature ODCs in steady‐state and disease.
Higher reliability and validity of Wavelet‐ALFF of resting‐state fMRI: From multicenter database and application to rTMS modulation
Authors: Yue Juan , Zhao Na , Qiao Yang , Feng Zi‐Jian , Hu Yun‐Song , Ge Qiu , Zhang Tian‐Qing , Zhang Zhu‐Qian , Wang Jue , Zang Yu‐Feng 
Published: November 2022

AbstractAmplitude of low‐frequency fluctuation (ALFF) has been widely used for localization of abnormal activity at the single‐voxel level in resting‐state fMRI (RS‐fMRI) studies. However, previous ALFF studies were based on fast Fourier transform (FFT‐ALFF). Our recent study found that ALFF based on wavelet transform (Wavelet‐ALFF) showed better sensitivity and reproducibility than FFT‐ALFF. The current study aimed to test the reliability and validity of Wavelet‐ALFF, and apply Wavelet‐ALFF to investigate the modulation effect of repetitive transcranial magnetic stimulation (rTMS). The reliability and validity were assessed on multicenter RS‐fMRI datasets under eyes closed (EC) and eyes open (EO) conditions (248 healthy participants in total). We then detected the sensitivity of Wavelet‐ALFF using a rTMS modulation dataset (24 healthy participants). For each dataset, Wavelet‐ALFF based on five mother wavelets (i.e., db2, bior4.4, morl, meyr and sym3) and FFT‐ALFF were calculated in the conventional band and five frequency sub‐bands. The results showed that the reliability of both inter‐scanner and intra‐scanner was higher with Wavelet‐ALFF than with FFT‐ALFF across multiple frequency bands, especially db2‐ALFF in the higher frequency band slow‐2 (0.1992–0.25 Hz). In terms of validity, the multicenter ECEO datasets showed that the effect sizes of Wavelet‐ALFF with all mother wavelets (especially for db2‐ALFF) were larger than those of FFT‐ALFF across multiple frequency bands. Furthermore, Wavelet‐ALFF detected a larger modulation effect than FFT‐ALFF. Collectively, Wavelet db2‐ALFF showed the best reliability and validity, suggesting that db2‐ALFF may offer a powerful metric for inspecting regional spontaneous brain activities in future studies.
Risk factors for fatal cardiac complications after allogeneic hematopoietic cell transplantation: Japanese Society for Transplantation and Cellular Therapy transplant complications working group
Authors: Yanagisawa Ryu , Tamaki Masaharu , Tanoshima Reo , Misaki Yukiko , Uchida Naoyuki , Koi Satoshi , Tanaka Takashi , Ozawa Yukiyasu , Matsuo Yayoi , Tanaka Masatsugu , Ikegame Kazuhiro , Katayama Yuta , Matsuoka Ken‐ichi , Ara Takahide , Kanda Yoshinobu , Matsumoto Kimikazu , Fukuda Takahiro , Atsuta Yoshiko , Kato Motohiro , Nakasone Hideki 
Published: November 2022

AbstractFatal cardiac complications can occur from the early to late phases after hematopoietic cell transplantation (HCT). Herein, the Japanese transplant registry database was used to retrospectively analyze health records of 33,791 allogeneic HCT recipients to elucidate the pathogenesis and risk factors involved. Overall, 527 patients died of cardiac complications at a median of 130 (range 0–3924) days after HCT. The cumulative incidence of fatal cardiac complications was 1.2% (95% confidence interval [CI]: 1.0–1.3) and 1.6% (95% CI: 1.5–1.8) at 1 and 5 years after HCT, respectively. Fatal cardiovascular events were significantly associated with an HCT‐specific comorbidity index (HCT‐CI) score of ≥1 specific to the three cardiovascular items, lower performance status, conditioning regimen cyclophosphamide dose of >120 mg/kg, and female sex. Cardiovascular death risk within 60 days after HCT was associated with the type of conditioning regimen, presence of bacterial or fungal infections at HCT, and number of blood transfusions. Contrastingly, late cardiovascular death beyond 1 year after HCT was associated with female sex and older age. Lower performance status and positive cardiovascular disease‐related HCT‐CI were risk factors for cardiac complications in all phases after HCT. Systematic follow‐up may be necessary according to the patients' risk factors and conditions.
Challenges with the current methodology for conducting Endangered Species Act risk assessments for pesticides in the United States
Authors: Teed R. Scott , Moore Dwayne R. J. , Vukov Oliver , Brain Richard A. , Overmyer Jay P. 
Published: November 2022

Abstract
The US Environmental Protection Agency (USEPA or the Agency) is responsible for administering the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). The Agency is also required to assess the potential risks of pesticides undergoing registration or re-registration to threatened and endangered (i.e., listed) species to ensure compliance with the Endangered Species Act. To assess potential risks to listed species, a screening-level risk assessment in the form of a biological evaluation (BE) is undertaken by the Agency for each pesticide. Given the large number of registration actions handled by the USEPA annually, efficient tools for conducting BEs are desirable. However, the “Revised Method” that is the basis for the USEPA's BE process has been ineffective at filtering out listed species and critical habitats that are at de minimis risk to pesticides. In the USEPA's BEs, the Magnitude of Effect Tool (MAGtool) has been used to determine potential risks to listed species that potentially co-occur with pesticide footprints. The MAGtool is a highly prescriptive, high-throughput compilation of existing FIFRA screening-level models with a geospatial interface. The tool has been a significant contributor to risk inflation and ultimately process inefficiency. The ineffectiveness of the tool stems from compounding conservatism, unrealistic and unreasonable assumptions regarding usage, limited application of species-specific data, lack of consideration of multiple lines of evidence, and inability to integrate higher-tier data. Here, we briefly describe the MAGtool and the critical deficiencies that impair its effectiveness, thus undermining its intention. Case studies are presented to highlight the deficiencies and solutions are recommended for improving listed species assessments in the future. Integr Environ Assess Manag 2023;19:817–829. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
The acceptance of telemedicine by physicians in Brazil: An institutional theory view
Authors: Palma Eduardo Moreira , Klein Amarolinda Zanela , Pedron Cristiane Drebes 
Published: November 2022

AbstractTelemedicine comprises different health services held at a distance and is a promising practice for inclusive health care. However, there is still no consensus in the literature about the factors that influence the acceptance and dissemination of these practices. Thus, this study analyzes the factors that influence the acceptance of telemedicine, more specifically, of teleconsultations, by physicians, and seeks to understand how institutional factors act to disseminate or prevent their acceptance. An exploratory and qualitative study was carried out in Brazil, through interviews with physicians from different specialties and documents analyzes. We analyzed documents from public hearings on the regulation of telemedicine, and reports, discussions, and videos about teleconsultations. We conducted two coding cycles of data and we identified 12 factors influencing the acceptance of telemedicine/teleconsultations. Seven of these factors had previously been identified in the literature, namely: Regulatory Factors, Level of Instruction and Preparation of Users, Resistance to Change, Technological Infrastructure, Value Perception, Organizational Characteristics, and Financial Support. Five other acceptance factors emerged from our empirical data: Corporatism, Possibilities by Medical Specialization, In‐Person Physical Examination, Commoditization of Telemedicine, and Previous Doctor–Patient Relationship. Based on Institutional Theory, we associated all the acceptance factors identified to the three institutional pillars, as in the study by Scott in 2014: Regulative, Normative, and Cultural Cognitive, also identifying main themes to which these factors are related, in each one of the three institutional pillars, respectively: regulation, structure, and lack of knowledge.
Mapping gene by early life stress interactions on child subcortical brain structures: A genome‐wide prospective study
Authors: Bolhuis Koen , Mulder Rosa H. , de Mol Casper Louk , Defina Serena , Warrier Varun , White Tonya , Tiemeier Henning , Muetzel Ryan L. , Cecil Charlotte A. M. 
Published: November 2022

AbstractBackgroundAlthough it is well‐established that both genetics and the environment influence brain development, they are typically examined separately. Here, we aimed to prospectively investigate the interactive effects of genetic variants—from a genome‐wide approach—and early life stress (ELS) on child subcortical brain structures, and their association with subsequent mental health problems.MethodPrimary analyses were conducted using data from the Generation R Study (N = 2257), including genotype and cumulative prenatal and postnatal ELS scores (encompassing life events, contextual risk, parental risk, interpersonal risk, direct victimisation). Neuroimaging data were collected at age 10 years, including intracranial and subcortical brain volumes (accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus). Genome‐wide association and genome‐wide‐by‐environment interaction analyses (GWEIS, run separately for prenatal/postnatal ELS) were conducted for eight brain outcomes (i.e., 24 genome‐wide analyses) in the Generation R Study (discovery). Polygenic scores (PGS) using the resulting weights were calculated in an independent (target) cohort (adolescent brain cognitive development Study; N = 10,751), to validate associations with corresponding subcortical volumes and examine links to later mother‐reported internalising and externalising problems.ResultsOne GWEIS‐prenatal stress locus was associated with caudate volume (rs139505895, mapping onto PRSS12 and NDST3) and two GWEIS‐postnatal stress loci with the accumbens (rs2397823 and rs3130008, mapping onto CUTA, SYNGAP1, and TABP). Functional annotation revealed that these genes play a role in neuronal plasticity and synaptic function, and have been implicated in neurodevelopmental phenotypes, for example, intellectual disability, autism, and schizophrenia. None of these associations survived a more stringent correction for multiple testing across all analysis sets. In the validation sample, all PGSgenotype were associated with their respective brain volumes, but no PGSGxE associated with any subcortical volume. None of the PGS associated with internalising or externalising problems.ConclusionsThis study lends novel suggestive insights into gene‐environment interplay on the developing brain as well as pointing to promising candidate loci for future replication and mechanistic studies.
Evaluating a communication aid for return of genetic results in families with hypertrophic cardiomyopathy: A randomized controlled trial
Authors: Burns Charlotte , Yeates Laura , Sweeting Joanna , Semsarian Christopher , Ingles Jodie 
Published: November 2022

AbstractGenetic testing for hypertrophic cardiomyopathy (HCM) is considered a key aspect of management. Communication of genetic test results to the proband and their family members, can be a barrier to effective uptake. We hypothesized that a communication aid would facilitate effective communication, and sought to evaluate knowledge and communication of HCM risk to at‐risk relatives. This was a prospective randomized controlled trial. Consecutive HCM patients attending a specialized clinic, who agreed to participate, were randomized to the intervention or current clinical practice. The intervention consisted of a genetic counselor‐led appointment, separate to their clinical cardiology review, and guided by a communication booklet which could be written in and taken home. Current clinical practice was defined as the return of the genetic result by a genetic counselor and cardiologist, often as part of a clinical cardiology review. The primary outcome was the ability and confidence of the individual to communicate genetic results to at‐risk relatives. The a priori outcome of improved communication among HCM families did not show statistically significant differences between the control and intervention group, though the majority of probands in the intervention group achieved fair communication (n = 13/22) and had higher genetic knowledge scores than those in the control group (7 ± 3 versus 6 ± 3). A total of 29% of at‐risk relatives were not informed of a genetic result in their family. Communication among HCM families remains challenging, with nearly a third of at‐risk relatives not informed of a genetic result. We show a significant gap in the current approach to supporting family communication about genetics. Australian New Zealand Clinical Trials Registry: ACTRN12617000706370.
Comparative performance of theoretical tools in order to quantify the effect of the electric potential on the vibrational wavenumbers and intensities of the SERS of 2‐methylpyrazine adsorbed on a nanostructured silver electrode
Authors: Valdivia Samuel , Aranda Daniel , Soto Juan , Otero Juan Carlos , López‐Tocón Isabel 
Published: November 2022

AbstractThe effect of the electrode potential in surface‐enhanced Raman scattering (SERS) intensities and wavenumbers of 2‐methylpyrazine (2MP) was analyzed on the basis of a resonant charge transfer (CT) mechanism by using a simple theoretical model in which the metallic surface and its charge density were simulated by atomic silver clusters of different size (n) and charge (q), [Agn]q. Two linear silver atoms (n = 2) with zero charge (q = 0) and three linear silver atoms (n = 3) with positive and negative charges (q = ±1) linked to the two nonequivalent aromatic nitrogen atoms in 2MP were taken into account. The wavenumber shifts of the most intense bands and the SERS‐CT spectra of these two types of metal‐adsorbate supermolecule, [Agn‐N1]q and [Agn‐N4]q, were calculated by using a time‐dependent density functional theory (TD‐DFT) method and the independent mode displaced harmonic oscillator (IMDHO) approximation. A comparison of the effect of different levels of calculation, ab initio/DFT, on the predictions from the two theoretical models (isolated adsorbate/supermolecule) is also performed. Only DFT theoretical results of the metal‐adsorbate supermolecule allow to explain the main role of the pair of bands assigned to totally symmetric ring‐stretching 8a,b modes. The 8a vibration is the strongest band at any electrode potential, whereas the 8b mode reaches a maximum enhancement at −0.50 V and then decreases at −0.75 V. This model of a charged metal‐adsorbate interface allows for detecting the presence of a CT mechanism in a SERS record.