bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning-based tool affects reproducibility of pes planus radiographic assessment
Authors: Koo Jalim , Hwang Sangchul , Han Seung Hwan , Lee Junho , Lee Hye Sun , Park Goeun , Kim Hyeongmin , Choi Jiae , Kim Sungjun 
Published: July 2022

AbstractAngle measurement methods for measuring pes planus may lose consistency by errors between observers. If the feature points for angle measurement can be provided in advance with the algorithm developed through the deep learning method, it is thought that the error between the observers can be reduced. A total of 300 weightbearing lateral radiographs were used for the development of the deep learning-based algorithm, and a total of 95 radiographs were collected for the clinical validation test set. Meary angle (MA) and calcaneal pitch (CP) were selected as measurement methods and measured twice by three less-experienced physicians with the algorithm-based tool and twice without. The intra- and inter-observer agreements of MA and CP measures were assessed via intra-class correlation coefficient. In addition, verification of the improvement of measurement performance by the algorithm was performed. Interobserver agreements for MA and CP measurements with algorithm were more improved than without algorithm. As for agreement with reference standard, combining the results of all readers, both MA and CP with algorithm were greater than those without algorithm. The deep learning algorithm tool is expected to improve the reproducibility of radiographic measurements for pes planus, especially by improving inter-observer agreement.
Structural diagnosis of benthic invertebrate communities in relation to salinity gradient in Baltic coastal lake ecosystems using biological trait analysis
Authors: Matela Mikołaj , Obolewski Krystian 
Published: July 2022

AbstractThis study is based on biological trait analysis (BTA), which provides a link between the distribution and biological characteristics of species. The paper investigates differences in the structure and functional diversity of benthic fauna in terms of seven biological traits (mobility, habitat, feeding type, habitat modification, body form, body size and feeding apparatus) in nine Baltic coastal lakes whose salinity ranged from 0.1 to 7.3 PSU. Mobile organisms were more common in lakes with higher salinity, while sessile and semi-mobile species preferred low-salinity or freshwater environments. There were also noticeable differences connected with feeding type: collectors and scrapers were more common in brackish lakes, and collectors were significantly dominant in freshwater and transitional ones. This indicates that Baltic coastal lakes are inhabited by similar species of benthic fauna, but that certain biological traits occur with different frequencies. We therefore identified features that may affect the functioning of coastal lakes with a relatively narrow salinity gradient (0.1–7.3 PSU). It seems to confirm the possibility of using BTA methods to determine key characteristics that are helpful for understanding the differences between aquatic ecosystems. The results may provide a basis for further research on changes in the functional diversity of lakes along the southern coast of the Baltic Sea, particularly in view of climate change, given their being small, shallow and less resilient lakes.
Artificial intelligence based optimization with deep learning model for blockchain enabled intrusion detection in CPS environment
Authors: Mansour Romany F. 
Published: July 2022

AbstractCyber physical system (CPS) is a network of cyber and physical elements, which interact with one another in a feedback form. CPS approves critical infrastructure and is treated as essential in day to day since it forms the basis of futuristic smart devices. An increased usage of CPSs poses security as a challenging issue and intrusion detection systems (IDS) can be applied for the identification of network intrusions. The latest advancements in the field of artificial intelligence (AI) and deep learning (DL) enables to design effective IDS models for the CPS environment. At the same time, metaheuristic algorithms can be employed as a feature selection approach in order to reduce the curse of dimensionality. With this motivation, this study develops a novel Poor and Rich Optimization with Deep Learning Model for Blockchain Enabled Intrusion Detection in CPS Environment, called PRO-DLBIDCPS technique. The proposed PRO-DLBIDCPS technique initially introduces an Adaptive Harmony Search Algorithm (AHSA) based feature selection technique for proper selection of feature subsets. For intrusion detection and classification, and attention based bi-directional gated recurrent neural network (ABi-GRNN) model is applied. In addition, the detection efficiency of the ABi-GRNN technique has been enhanced by the use of Poor and rich optimization (PRO) algorithm based hyperparameter optimizer, which resulted in enhanced intrusion detection results. Furthermore, blockchain technology is applied for enhancing security in the CPS environment. In order to demonstrate the enhanced outcomes of the PRO-DLBIDCPS technique, a wide range of simulations was carried out on benchmark dataset and the results reported the better outcomes of the PRO-DLBIDCPS technique in terms of several measures.
Use of waste fish oil biodiesel blended with aluminium oxide nanoparticle in IC engines: an experimental on performance, combustion and emission study
Authors: Thamarai Kannan B. , Sathish T. , Sathyamurthy Ravishankar , Erko Kuma Gowwomsa 
Published: July 2022

AbstractAlternate fuels are in great need as the world's natural resources are depleting with continuous consumption. Furthermore, with a continuous increase in the use of conventional fuel which emits a large number of harmful pollutants to the environment and thus increasing global warming, the need for alternative fuel is in great need. This investigation thus focused on the impact identification on the use of biodiesel from fish waste-based biodiesel [BDWFO (Bio-Diesel of Waste Fish Oil)] with Nanoparticles in single cylinder water cooled IC engine. The fish wastes in fish processing industries/fish markets are used to produce oil and its biodiesel is produced by the transesterification method. The individual BDWFO, Diesel, and blends of 20% of BDWFO were tested with the engine. Then another two combinations of fuel created 200 ppm of 40 nm Aluminium Oxide nanoparticles (AN) mixed with BDWFO, blends of 20% of BDWFO. These five fuels were considered to study the engine performance, combustion, and emissions from the exhaust. The experimental results confirmed the presence of aluminium oxide nanoparticles in BDWFO provides improved engine performance and reduced emissions from exhaust gas except for CO2.
Quantitative analysis of exosomes in the aqueous humor of Korean patients with pseudoexfoliation glaucoma
Authors: An Hyo Jung , Cho Hyun-kyung , Song Dae Hyun , Kee Changwon 
Published: July 2022

AbstractWe aimed to quantitatively analyze the exosome and its cargo in individual aqueous humor (AH) samples from pseudoexfoliation (PEX) glaucoma patients compared to controls using a novel detection platform. We investigated the size distribution and measured the quantitative exosome particle counts in each AH sample. AH (80–120 µL) was obtained during cataract surgery or glaucoma filtering surgery from 12 Korean subjects (six with PEX glaucoma and six age-matched controls). The mean size of the exosomes was 58.9 ± 18.5 nm measured by a tangential flow filtration system using single-particle interferometric reflectance imaging sensor. Exosome particle count in each CD 63, CD 81, and CD9 spot was significantly greater in PEX glaucoma than in controls in total, CD 63, CD9, syntenin, and scattering(all p < 0.003). The CD63 spot showed a particle count of 8319.1 ± 797.7 in PEX glaucoma patients and 4786.8 ± 1302.1 in controls (p = 1.88E−11). Individual fluorescent capture spot images also revealed denser exosome particles in PEX patients than in controls. Syntenin, indicating exosomal origin, was detected in all AH samples. Exosomes differentially detected in AH suggest the possible role of exosomes in the pathogenesis of PEX glaucoma.
Clinical identification of the stimulus intensity to measure temporal summation of second pain
Authors: Moriguchi Daisuke , Ishigaki Shoichi , Lin Xiaoyu , Kuyama Kotaro , Koishi Yukiko , Takaoka Ryota , Svensson Peter , Yatani Hirofumi 
Published: July 2022

AbstractTemporal summation of second pain (TSSP) has been suggested as a psychophysical index for central sensitization, one of the critical mechanisms in the chronification of pain. However, there is no gold standard for protocols to measure TSSP. The purpose was to establish the stimulus intensity for measuring TSSP. Female patients with chronic myofascial temporomandibular disorders pain (n = 16) and healthy female volunteers with no pain (n = 15) participated. Pain thresholds (PT °C) were measured, and repetitive heat stimuli at three stimulus intensities (PT °C, PT + 1 °C, PT + 2 °C) were applied. TSSP parameters were quantified as TSSP magnitude (TSm) and TSSP frequency (TSf). In healthy female volunteers, pain ratings significantly decreased at PT °C (p < 0.050), besides TSm and TSf at PT + 2 °C were significantly higher than those at PT °C (p < 0.025). In chronic pain patients, pain ratings significantly increased at PT + 1 °C and PT + 2 °C (p < 0.050). At PT + 2 °C, TSm and TSf in chronic pain patients were significantly higher than those in healthy volunteers (p < 0.050). It could be helpful to measure TSSP with the stimulus intensity adjusted individually to the patient’s pain thresholds + 2 °C for assessing central sensitization.
Prime editor-mediated correction of a pathogenic mutation in purebred dogs
Authors: Kim Dong Ern , Lee Ji Hye , Ji Kuk Bin , Lee Eun Ji , Li Chuang , Oh Hyun Ju , Park Kang Sun , Lee Seung Hoon , Koo Okjae , Kim Min Kyu 
Published: July 2022

AbstractCanine hip dysplasia (HD) is a multifactorial disease caused by interactions between genetic and environmental factors. HD, which mainly occurs in medium- to large-sized dogs, is a disease that causes severe pain and requires surgical intervention. However, the procedure is not straight-forward, and the only way to ameliorate the situation is to exclude individual dogs with HD from breeding programs. Recently, prime editing (PE), a novel genome editing tool based on the CRISPR-Cas9 system, has been developed and validated in plants and mice. In this study, we successfully corrected a mutation related to HD in Labrador retriever dogs for the first time. We collected cells from a dog diagnosed with HD, corrected the mutation using PE, and generated mutation-corrected dogs by somatic cell nuclear transfer. The results indicate that PE technology can potentially be used as a platform to correct genetic defects in dogs.
Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network
Authors: Shimamura Yuko , Furuhashi Kazuhiro , Tanaka Akihito , Karasawa Munetoshi , Nozaki Tomoya , Komatsu Shintaro , Watanabe Kenshi , Shimizu Asuka , Minatoguchi Shun , Matsuyama Makoto , Sawa Yuriko , Tsuboi Naotake , Ishimoto Takuji , Suzuki Hiroshi I. , Maruyama Shoichi 
Published: July 2022

AbstractAdipose-derived mesenchymal stem cells (ASCs) have shown therapeutic potentials against refractory diseases. However, the detailed therapeutic mechanisms remain unclear. Here, we report the therapeutic actions of human ASCs in nephritis, focusing on cellular dynamics and multi-organ networks. Intravenously-administered ASCs accumulated in spleen but not kidneys. Nevertheless, ASCs increased M2 macrophages and Tregs in kidneys and drove strong renoprotection. Splenectomy abolished these therapeutic effects. ASC-derived extracellular vesicles (EVs) were transferred to M2 macrophages, which entered the bloodstream from spleen. EVs induced the transcriptomic signatures of hyperpolarization and PGE2 stimulation in M2 macrophages and ameliorated glomerulonephritis. ASCs, ASC-derived EVs, and EV-transferred M2 macrophages enhanced Treg induction. These findings suggest that EV transfer from spleen-accumulated ASCs to M2 macrophages and subsequent modulation of renal immune-environment underlie the renoprotective effects of ASCs. Our results provide insights into the therapeutic actions of ASCs, focusing on EV-mediated modulation of macrophages and the spleen-kidney immune network.
Tunable electromagnetic properties of Ti3C2Tx/rGO foams decorated with NiO particles
Authors: Zhang Fan , Shang Siyang , Li Yaya , Fan Bingbing , Zhang Rui , Zhao Biao , Lu Hongxia , Ma Chengliang 
Published: July 2022

Ti3C2Tx MXene-based composites are attractive for using as the electromagnetic wave absorption (EMA) materials due to the multiple polarizations.
Monitoring orthodontic tooth movement in rats after piezocision by bone scintigraphy
Authors: Beindorff Nicola , Papadopoulos Nikolaos , Hoffmann Stefan , Mohan Ajay-Mohan , Lukas Mathias , Brenner Winfried , Jost-Brinkmann Paul-Georg , Präger Thomas 
Published: July 2022

Abstract
Aim Piezocision, corticocision of mineralized tissue by ultrasound showed promising results in accelerating tooth movement induced by orthodontic appliances although the biologic effects of this procedure are not well-understood so far. The aim of this study was to investigate the impact of piezocision on bone remodeling in rats by bone SPECT imaging.
Material and Methods Ten male Wistar rats underwent surgical placement of orthodontic appliances on each side of the maxilla followed by piezocision on one side only. Each rat underwent 99mTc-MDP bone SPECT/CT imaging before surgery (T0), and 2 (T1) and 4 weeks (T2) after surgery. Bone uptake is expressed as median [IQR] min-max in percentage of the injected activity per ml computed from the 10 voxels with the highest uptake (%IAmax10/ml).
Results Pooled data regardless of the piezocision showed a significant increase in bone uptake from T0 (3.2 [2.8–3.9] 2.6–4.9) to T1 (4.4 [3.8–4.6] 3.4–4.8; p = 0.001). Thereafter, the uptake decreased to T2 (3.8 [3.1–4.4] 2.8–4.8; p = 0.116). No significant differences in bone uptake were found between the maxilla sides without and with piezocision: T1: without (4.3 [3.8–4.5] 3.4–4.8) vs. with (4.5 [3.7–4.6] 3.5–4.7; p=0.285), T2: without (4.0 [3.1–4.5] 2.8–4.8) vs. with (3.7 [3.0–4.4] 2.8–4.8; p=0.062).
Conclusion
99mTc-MDP bone SPECT imaging in rats was able to reproduce changes in bone uptake in the maxilla after placement of orthodontic appliances inducing measurable tooth movement. An additional effect of piezocision on bone remodeling in terms of bone uptake was not detectable which is probably due to the pronounced and significant effects induced by the orthodontic appliances per se, which may mask the potential effects of additional piezocision.
Aachener Sturzpass App
Authors: Rasche Peter , Schäfer Katharina , Theis Sabine , Seinsch Tobias , Bröhl Christina , Wille Matthias , Knobe Matthias , Vollmar Horst Christian , Mertens Alexander 
Published: July 2022

ZUSAMMENFASSUNGStürze sind eine große Herausforderung für Betroffene und das Gesundheitswesen. Die „Aachener Sturzpass App“ ist eine digitale Gesundheitsanwendung, die es älteren Patienten (Personen über 50 Jahre) ermöglicht, ihr individuelles Sturzrisiko selbstständig via Smartphone einzuschätzen und zu überwachen. Die Selbsteinschätzung basiert auf der „Aachener Sturzpräventionsskala“, die aus 3 Schritten besteht. Zunächst beantworten die Patienten 10 standardisierte Ja-Nein-Fragen (positives Kriterium ≥ 5 „Ja“-Antworten). Zweitens wird ein 10 Sekunden andauernder Test des freien Stehens ohne Ausgleichsbewegung durchgeführt (positives Kriterium: Ausgleichsbewegung). Im dritten Schritt schließlich bewerten die Patienten ihr subjektives Sturzrisiko auf einer 10-Punkte-Likert-Skala, ausgehend von einer Erläuterung der positiven Kriterien der Testschritte 1 und 2.
Regionale Hospiz- und Palliativnetzwerke in Niedersachsen: Ergebnisse einer Online-Bestandserhebung und -analyse
Authors: Schwabe Sven , Fischer Rosemarie , Herbst Franziska A. , Schleef Tanja , Schneider Nils 
Published: July 2022

Zusammenfassung
Ziel der Studie Der Bestand von regionalen Hospiz- und Palliativnetzwerken (RHPN) in Niedersachsen soll erstmals exploriert und analysiert werden.
Methodik Im Februar 2022 wurde via SoSciSurvey eine Online-Befragung von RHPN in Niedersachsen durchgeführt. Inhalt der Befragung waren: a) Netzwerkorganisation und -struktur, b) Themen und Tätigkeitsfelder, c) Herausforderungen und Unterstützungsbedarfe. Der Befragungslink wurde an alle registrierten Palliativstützpunkte (n=33) und SAPV-Teams (n=43) in Niedersachsen versendet. Die Daten wurden deskriptiv in Microsoft Excel 2016 ausgewertet.
Ergebnisse Insgesamt haben 34 RHPN aus 33 Landkreisen und Städten teilgenommen, wovon 29 Träger eines SAPV-Teams waren. Häufigste Inhalte der Netzwerkarbeit sind die Themen SAPV (n=32), ambulante Hospizarbeit (n=22) und die Versorgung in Pflegeeinrichtungen (n=22).
Schlussfolgerung RHPN in Niedersachsen sind vielfältig und eng mit den ambulanten Strukturen der Hospizarbeit und der SAPV verbunden.
Recent Progress in C(sp2)–C(sp2) Bond Formation Using Ligand Coupling on Sulfur(IV)
Authors: Morofuji Tatsuya , Kano Naokazu 
Published: July 2022

AbstractLigand coupling on sulfur, as an alternative to transition-metal-catalyzed cross-coupling reactions, is a useful method for connecting sp2 carbons. Although pioneered more than 50 years ago, its synthetic utility has been overlooked until recently. This short review summarizes progress in C(sp2)–C(sp2) bond formation using ligand coupling on sulfur and discusses control of selectivity, expansion of the scope, and applications of the reaction.1	Introduction2	Cross-Coupling of Heteroaryl Reagents3	Phenothiazinium-Mediated C(sp2)–C(sp2) Cross-Coupling4	C(sp2)–C(sp2) Bond Formation Mediated by Sulfuranes Generated from Arynes and Sulfoxides5	S-Alkenylbenzothiophenium-Mediated Alkenyl-Alkenyl Coupling6	Conclusion
Recent Advances in Transition-Metal-Catalyzed Cross-Coupling Reactions of gem-Difluorinated Cyclopropanes
Authors: Xia Ying , Zhu Yulei , Zeng Yaxin , Jiang Zhong-Tao 
Published: July 2022

AbstractAs a special class of cyclopropanes, gem-difluorinated cyclopropanes have many fascinating properties as a result of the gem-difluoro substitution; thus, their reactions have received much attention from the synthetic chemistry community. Recently, gem-difluorinated cyclopropanes have gradually emerged as a type of novel and unique fluorinated allylic synthon in cross-coupling reactions for the synthesis of monofluoroalkenes. Herein, we briefly summarize recent advances in transition-metal-catalyzed reactions of gem-difluorinated cyclopropanes.1	Introduction2	Palladium-Catalyzed Reactions with Linear Selectivity3	Palladium-Catalyzed Reactions with Branched Selectivity4	Other Metal-Catalyzed Reactions5	Conclusions
Catalytic Enantioselective Desymmetrization of meso-Cyclopropane-Fused Cyclohexene-1,4-diones by a Formal C(sp2)–H Alkylation
Authors: Mukherjee Santanu , Ray Sayan 
Published: July 2022

AbstractA bicyclo[4.1.0]heptane framework consisting of cis-fused cyclopropane and cyclohexane rings is found in several bioactive compounds. Given the symmetry of this core, catalytic desymmetrization can be considered as the most straightforward strategy for its enantioselective synthesis. Known desymmetrization reactions of meso-bicyclo[4.1.0]heptane derivatives proceed with opening of the cyclopropane ring. We now report the first ring-retentive desymmetrization of bicyclo[4.1.0]heptane derivatives, namely meso-cyclopropane-fused cyclohexene-1,4-diones, through a formal C(sp2)-H alkylation using a nitroalkane as the alkylating agent. This reaction is catalyzed by a dihydroquinine-derived bifunctional tertiary aminosquaramide and generates the products with up to 97:3 er. An application of this reaction is demonstrated by the first catalytic enantioselective synthesis of the natural product (–)-car-3-ene-2,5-dione.
Boron Trifluoride Etherate-Controlled Reactions of Methyl Enol Ethers: Selective Synthesis of Dihydrofuro[3,2-c]chromenone and Furo[3,2-c]chromenone Derivatives
Authors: Khan Faiz Ahmed , Ahmad Sarwat Asma Ziya 
Published: July 2022

AbstractA facile one-step synthetic approach to dihydrofuro-[3,2-c]chromenones and furo[3,2-c]chromenones by the reaction of methyl enol ethers with 4-hydroxycoumarins under metal-free conditions is presented. Dihydrofuro[3,2-c]chromenones and furo[3,2-c]-chromenones were selectively obtained by controlling the stoichiometry of boron trifluoride diethyl etherate. An unexpected aryl-group migration followed by aromatization of the furan moiety, leading to a variety of furo[3,2-c]chromenone derivatives in good yields, is reported.
Percutaneous Cannulation of Femoral Vessels in Minimally Invasive Cardiac Surgery
Authors: Sugimura Yukiharu , Jandali Hassan , Immohr Moritz Benjamin , Katahira Shintaro , Minol Jan-Philipp , Lichtenberg Artur , Akhyari Payam 
Published: July 2022

Abstract
Objective Despite the recent trend of access miniaturization in minimally invasive cardiac surgery (MICS) surgical “cut down (CD)” for femoral cannulation remains the standard at many centers. Percutaneous vascular closure (PVC) devices have recently been introduced for minimizing invasiveness during interventional diagnostic and therapy. This report summarizes the initial experience with this new approach in the setting of MICS, with a special focus on safety and advantages.
Methods Percutaneous cannulation with a standard protocol including preoperative computer tomography imaging and intraoperative point-of-care ultrasound guidance was performed in 93 consecutive patients from September 2018 until February 2020, while conventional “CD” procedure performed in 218 patients in the previous period. We analyzed patients' characteristics and compared access site complications of PVC group versus conventional “CD” group.
Results As far as operative/postoperative outcome, the duration of intensive care unit stay as well as hospital stay was statistically shorter in PVC compared with CD (CD vs. PVC: 2.74 ± 3.83 vs. 2.16 ± 2.01 days, p < 0.01, 16.7 ± 8.75 vs. 13.0 ± 4.96 days, p < 0.001, respectively). Further, we found no femoral infection or lymphocele in the PVC group, whereas 4 cases of wound complications were observed in the CD group.
Conclusion According to our results, percutaneous closure system for femoral vessels in MICS seems to be beneficial with the assist of preoperative computed tomography and intraoperative Doppler guidance.