bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive accuracy of adding shock index to the American College of Surgeons’ minimum criteria for full trauma team activation
Authors: McCormick Taylor , Haukoos Jason , Hopkins Emily , Trent Stacy , Adelgais Kathleen , Platnick Barry , Cohen Mitchell 
Published: February 2022

AbstractBackgroundThe American College of Surgeons requires trauma centers to use six minimum criteria (ACS‐6) for full trauma team activation: hypotension, gunshot wound to the neck or torso, Glasgow Coma Scale (GCS) score < 9, respiratory compromise, transfers receiving blood transfusion, or physician discretion. Our goal was to evaluate the effect of adding varying shock index (SI) thresholds to the ACS‐6 in an adult trauma population with the hypothesis that SI would significantly improve sensitivity at the expense of an acceptable decrease in specificity.MethodsWe performed a secondary analysis of EMS and trauma registry data from an urban Level I trauma center. Consecutive patients > 15 years of age were included from 1993 through 2006. SI at thresholds of ≥0.8, ≥0.85, ≥0.9, and ≥1 were evaluated. Primary outcome was emergency operative (within 1 h of arrival) or procedural (cricothyrotomy or thoracotomy) intervention (EOPI); secondary outcomes were Injury Severity Score (ISS) > 15, ISS > 24, a composite of EOPI or ISS > 15, and urgent operative intervention (within 4 h).ResultsA total of 20,872 patients were included, 27% with an ISS > 15 and 5% who underwent EOPI. Sensitivity and specificity of the ACS‐6 alone for EOPI were 86% (95% confidence interval [CI] = 84% to 88%) and 81% (95% CI = 80% to 81%), respectively. Inclusion of SI thresholds of 0.8, 0.85, 0.9, and 1 resulted in sensitivities of 95% (95% CI = 93% to 96%), 93% (CI = 91% to 94%), 92% (95% CI = 90% to 93%), and 90% (95% CI = 88% to 92%), respectively, and specificities of 52% (95% CI = 51% to 52%), 59% (95% CI = 58% to 59%), 64% (95% CI = 64% to 65%), and 72% (95% CI = 71% to 73%), respectively. Similar trends were found for each secondary outcome.ConclusionThe addition of SI to the ACS‐6 for trauma team activation increased sensitivity for EOPI with a larger decrease in specificity across all thresholds. Inclusion of a SI threshold of ≥0.9 closely aligns with under‐ and overtriage benchmarks in this trauma registry cohort using a strict definition of trauma team activation need.
Quality of performance metrics, informal peer monitoring and goal commitment
Authors: Gomez‐Conde Jacobo , Lopez‐Valeiras Ernesto , Malagueño Ricardo , Oyadomari José Carlos Tiomatsu 
Published: February 2022

AbstractWe examine whether the quality of performance metrics affects informal peer monitoring and, in turn, goal commitment. By fostering performance‐oriented behaviours, performance metrics drive managers to involve themselves in learning and improvement efforts, building a fertile atmosphere for informal peer monitoring. We argue that the quality of performance metrics is positively associated with direct peer monitoring and negatively linked to indirect peer monitoring. Subsequently, we postulate that direct (indirect) peer monitoring is positively (negatively) associated with goal commitment. We use partial least squares (PLS) to analyse survey data from store managers in a large retail firm. Results provide overall support for our hypotheses.
Notre‐Dame‐des‐Landesor Redefining the Relationship to Space through the Territorial Embeddedness of a Struggle
Authors: Florez Marion , Baudelle Guy , Hardouin Magali 
Published: February 2022

AbstractBy using an empirical method to investigate the occupied site of a renowned airport mega‐project near Nantes (so‐called Notre‐Dame‐des‐Landes, France), the paper examines the socio‐spatial effects of territorial mobilisation. We consider how the territorial embeddedness of a struggle helps reshape the relationship to space for the occupants of the contested zone. Starting from an analysis of the forms of “inhabiting” and “cohabitation” of the heterogeneous “occupying‐inhabitants” in the disputed zone, we stress how the relationship with others and to space operates over the long term. More attention is paid to describing the plural representations of the territory, which clash, converge and are unified alternately, ultimately creating a “territory of struggle(s)”, which has become iconic in France.
Risk of hepatocellular carcinoma in treatment‐naïve chronic hepatitis B patients receiving tenofovir disoproxil fumarate versus entecavir in the United States
Authors: Kim W. Ray , Telep Laura E. , Jump Belinda , Lu Mei , Ramroth Heribert , Flaherty John , Gaggar Anuj , Chokkalingam Anand P. , Gordon Stuart C. 
Published: February 2022

SummaryBackgroundEntecavir (ETV) and tenofovir disoproxil fumarate (TDF) are the first‐line treatment agents for chronic hepatitis B virus (HBV). Recently, whether the degree to which the risk of hepatocellular carcinoma (HCC) may be reduced by ETV vs TDF has been debated. We compared the incidence of HCC among treatment‐naïve patients receiving TDF vs ETV in the United States.MethodsFrom a large administrative medical claims database of commercially insured patients, we identified 166,933 adults with a diagnosis of chronic hepatitis B and a minimum of 12 months of prior enrolment, of whom 3934 and 6127 initiated ETV and TDF respectively. Fine‐Gray hazard regression models incorporating treatment propensity scores (PS) were used to estimate the risk of HCC incidence associated with TDF vs ETV; variables considered for adjustment included demographic characteristics, concomitant medication use and baseline comorbidities, as well as competing events including liver transplantation and medication changes.ResultsAfter PS weighting, the TDF and ETV groups were well‐matched. During the follow‐up, 90 patients developed HCC, including 50 receiving ETV and 40 receiving TDF, giving rise to crude incidence rates of 0.62 per 100 person‐years (PY) and 0.30 per 100 PY respectively. In PS‐weighted, multivariable analysis, TDF was associated with a subdistribution hazard ratio for HCC of 0.58 (95% confidence interval [CI]: 0.38–0.89) compared to ETV. Results were similar when patients ≥40 years and men and women were analysed separately.ConclusionAmong commercially insured, treatment‐naïve patients with chronic hepatitis B in the United States, treatment with TDF was associated with significantly lower risk of HCC than ETV.
Deferasirox in the management of iron overload in patients with myelofibrosis treated with ruxolitinib: The multicentre retrospective RUX‐IOL study
Authors: Elli Elena Maria , Di Veroli Ambra , Bartoletti Daniela , Iurlo Alessandra , Carmosino Ida , Benevolo Giulia , Abruzzese Elisabetta , Bonifacio Massimiliano , Bergamaschi Micaela , Polverelli Nicola , Caramella Marianna , Cilloni Daniela , Tiribelli Mario , Pugliese Novella , Caocci Giovanni , Crisà Elena , Porrini Raffaele , Markovic Uros , Renso Rossella , Auteri Giuseppe , Cattaneo Daniele , Trawinska Malgorzata Monika , Scaffidi Luigi , Biale Lucia , Bucelli Cristina , Breccia Massimo , Gambacorti‐Passerini Carlo , Palumbo Giuseppe Alberto , Latagliata Roberto , Palandri Francesca 
Published: February 2022

SummaryDeferasirox (DFX) is used for the management of iron overload (IOL) in many haematological malignancies including myelofibrosis (MF). The ‘RUX‐IOL’ study retrospectively collected 69 MF patients treated with ruxolitinib (RUX) and DFX for IOL to assess: safety, efficacy in term of iron chelation response (ICR) and erythroid response (ER), and impact on overall survival of the combination therapy. The RUX–DFX therapy was administered for a median time of 12.4 months (interquartile range 3.1–71.2). During treatment, 36 (52.2%) and 34 (49.3%) patients required RUX and DFX dose reductions, while eight (11.6%) and nine (13.1%) patients discontinued due to RUX‐ or DFX‐related adverse events; no unexpected toxicity was reported. ICR and ER were achieved by 33 (47.8%) and 32 patients (46.4%) respectively. Thirteen (18.9%) patients became transfusion‐independent. Median time to ICR and ER was 6.2 and 2 months respectively. Patients achieving an ER were more likely to obtain an ICR also (p = 0.04). In multivariable analysis, the absence of leukocytosis at baseline (p = 0.02) and achievement of an ICR at any time (p = 0.02) predicted improved survival. In many MF patients, the RUX–DFX combination provided ICR and ER responses that correlated with improved outcome in the absence of unexpected toxicities. This strategy deserves further clinical investigation.
Rage donations and mobilization: Understanding the effects of advocacy on collective giving responses
Authors: Chapman Cassandra M. , Lizzio‐Wilson Morgana , Mirnajafi Zahra , Masser Barbara M. , Louis Winnifred R. 
Published: February 2022

AbstractAdvocacy is intended to change people's attitudes and behavior. Yet the psychological and behavioral consequences of advocacy have rarely been considered. Across 3 experiments (combined N = 934) in the contexts of debates around racial discrimination and abortion, we investigated if and how exposure to advocacy can influence collective giving responses: self‐reported willingness to make donations congruent with one's beliefs on the issue and actual giving behavior. Reading tweets from one's own side of a contentious debate sometimes indirectly mobilized collective giving responses by enhancing perceptions of efficacy and ensuring people empathized and identified with highlighted victim groups. Simultaneously, however, supporting advocacy sometimes inadvertently suppressed action by reducing anger and perceived injustice. Results therefore show that advocacy can simultaneously mobilize and demobilize support. However, effects were not found consistently across contexts and donation measures. Overall, mobilization pathways were stronger, especially on donation behavior and in the context of the abortion debate. Results suggest advocacy can work broadly as intended: by influencing the attitudes and behaviors of audience members. Online advocacy exposure in social media echo chambers may therefore be contributing to political polarization. Finally, results also demonstrate that charitable giving can be a form of collective action.
CXCL12 promotes CCR7 ligand–mediated breast cancer cell invasion and migration toward lymphatic vessels
Authors: Hayasaka Haruko , Yoshida Junichi , Kuroda Yasutaka , Nishiguchi Akihiro , Matsusaki Michiya , Kishimoto Kei , Nishimura Hitoshi , Okada Mari , Shimomura Yuki , Kobayashi Daichi , Shimazu Yoshihito , Taya Yuji , Akashi Mitsuru , Miyasaka Masayuki 
Published: February 2022

AbstractChemokines are a family of cytokines that mediate leukocyte trafficking and are involved in tumor cell migration, growth, and progression. Although there is emerging evidence that multiple chemokines are expressed in tumor tissues and that each chemokine induces receptor‐mediated signaling, their collaboration to regulate tumor invasion and lymph node metastasis has not been fully elucidated. In this study, we examined the effect of CXCL12 on the CCR7‐dependent signaling in MDA‐MB‐231 human breast cancer cells to determine the role of CXCL12 and CCR7 ligand chemokines in breast cancer metastasis to lymph nodes. CXCL12 enhanced the CCR7‐dependent in vitro chemotaxis and cell invasion into collagen gels at suboptimal concentrations of CCL21. CXCL12 promoted CCR7 homodimer formation, ligand binding, CCR7 accumulation into membrane ruffles, and cell response at lower concentrations of CCL19. Immunohistochemistry of MDA‐MB‐231–derived xenograft tumors revealed that CXCL12 is primarily located in the pericellular matrix surrounding tumor cells, whereas the CCR7 ligand, CCL21, mainly associates with LYVE‐1+ intratumoral and peritumoral lymphatic vessels. In the three‐dimensional tumor invasion model with lymph networks, CXCL12 stimulation facilitates breast cancer cell migration to CCL21‐reconstituted lymphatic networks. These results indicate that CXCL12/CXCR4 signaling promotes breast cancer cell migration and invasion toward CCR7 ligand–expressing intratumoral lymphatic vessels and supports CCR7 signaling associated with lymph node metastasis.
Ulcerating nodules on a background of lower leg lymphoedema
Authors: Steyn Mia , Nardini Nastassia , Attard Natalie Rachel 
Published: February 2022

Abstract
A patient presented with a 3-month history of a rapidly enlarging ulcerated tumour on his lower leg, occurring on a background of chronic idiopathic lymphoedema of approximately 10 years' duration. Histology revealed extensive infiltration of the dermis by a vascular tumour with pleomorphic and hyperchromatic endothelial cells, which stained positive for vascular markers CD31, CD34 and ERG. A diagnosis of lymphoedema-associated angiosarcoma was reached and our patient was treated with isolated limb perfusion with high-dose melphalan and tumour necrosis factor-alfa.
Peri‐zygomatic infection associated with zygomatic implants: A retrospective longitudinal cohort study
Authors: Vrielinck Luc , Moreno‐Rabie Catalina , Schepers Serge , Van Eyken Peter , Coucke Wim , Politis Constantinus 
Published: February 2022

AbstractObjectivesThe main objective of this retrospective, longitudinal, cohort study was to describe the occurrence of peri‐zygomatic infection (PZI) as a complication associated with zygomatic implant (ZI) placement in a period of 22 years.Materials and methodsA retrospective search was carried out in the department of oral and maxillofacial surgery of Saint John's hospital in Genk, Belgium. Patients that had a severely atrophic fully or partially edentulous maxilla, and at least one ZI placed, were included.ResultsA total of 302 eligible patients, underwent ZI surgery between 1998 and 2020. From a total of 940 ZI, 45 were associated with the development of PZI. PZI was located in the upper portion of the cheek in relation to the external corner of the eye, one or two centimeters under the lower lid. The total number of affected patients was 25 (8.3%), who had a mean age of 58.1 years. In this subset, PZI occurred in 15 cases on the right side, in eight cases on the left side, and in two cases bilaterally. Ultimately, 16 ZI were lost in the PZI site. The mean time since the implant placement to the diagnosis of PZI was 1.9 years (SD ±2.4) and to the ZI removal of 3.8 years (SD ±3.7). After implant removal, the PZI symptomatology dissipated in all patients.ConclusionPeri‐zygomatic infection should be informed to the patients as a possible complication after ZI placement. Once identified, it should be acknowledged as a risk factor for ZI failure.
Antibody‐mediated rejection after kidney transplantation in children; therapy challenges and future potential treatments
Authors: Bertacchi Massimiliano , Parvex Paloma , Villard Jean 
Published: February 2022

AbstractAntibody‐mediated rejection (AMR) remains one of the most critical problems in renal transplantation, with a significant impact on patient and graft survival. In the United States, no treatment has received FDA approval jet. Studies about treatments of AMR remain controversial, limited by the absence of a gold standard and the difficulty in creating large, multi‐center studies. These limitations emerge even more in pediatric transplantation because of the limited number of pediatric studies and the occasional use of some therapies with unknown and poorly documented side effects. The lack of recommendations and the unsharp definition of different forms of AMR contribute to the challenging management of the therapy by pediatric nephrologists. In an attempt to help clinicians involved in the care of renal transplanted children affected by an AMR, we rely on the latest recommendations of the Transplantation Society (TTS) for the classification and treatment of AMR to describe treatments available today and potential new treatments with a particular focus on the pediatric population.
Visually sensitive seizures: An updated review by the Epilepsy Foundation
Authors: Fisher Robert S. , Acharya Jayant N. , Baumer Fiona Mitchell , French Jacqueline A. , Parisi Pasquale , Solodar Jessica H. , Szaflarski Jerzy P. , Thio Liu Lin , Tolchin Benjamin , Wilkins Arnold J. , Kasteleijn‐Nolst Trenité Dorothée 
Published: February 2022

AbstractLight flashes, patterns, or color changes can provoke seizures in up to 1 in 4000 persons. Prevalence may be higher because of selection bias. The Epilepsy Foundation reviewed light‐induced seizures in 2005. Since then, images on social media, virtual reality, three‐dimensional (3D) movies, and the Internet have proliferated. Hundreds of studies have explored the mechanisms and presentations of photosensitive seizures, justifying an updated review. This literature summary derives from a nonsystematic literature review via PubMed using the terms “photosensitive” and “epilepsy.” The photoparoxysmal response (PPR) is an electroencephalography (EEG) phenomenon, and photosensitive seizures (PS) are seizures provoked by visual stimulation. Photosensitivity is more common in the young and in specific forms of generalized epilepsy. PS can coexist with spontaneous seizures. PS are hereditable and linked to recently identified genes. Brain imaging usually is normal, but special studies imaging white matter tracts demonstrate abnormal connectivity. Occipital cortex and connected regions are hyperexcitable in subjects with light‐provoked seizures. Mechanisms remain unclear. Video games, social media clips, occasional movies, and natural stimuli can provoke PS. Virtual reality and 3D images so far appear benign unless they contain specific provocative content, for example, flashes. Images with flashes brighter than 20 candelas/m2at 3‐60 (particularly 15‐20) Hz occupying at least 10 to 25% of the visual field are a risk, as are red color flashes or oscillating stripes. Equipment to assay for these characteristics is probably underutilized. Prevention of seizures includes avoiding provocative stimuli, covering one eye, wearing dark glasses, sitting at least two meters from screens, reducing contrast, and taking certain antiseizure drugs. Measurement of PPR suppression in a photosensitivity model can screen putative antiseizure drugs. Some countries regulate media to reduce risk. Visually‐induced seizures remain significant public health hazards so they warrant ongoing scientific and regulatory efforts and public education.
Teaching Pentecostalism in World Christianity
Authors: Asamoah‐Gyadu J. Kwabena 
Published: February 2022

AbstractThe major heartlands of Christianity have, since the middle of the 20th century, shifted gradually from the West to the global South and East. This shift has resulted not only in Christianity becoming the dominant religion of Africa, but also in its transformation into a primarily non‐Western faith. This article contends that in line with that development, Africa has become one of Christianity’s most dynamic and vibrant hubs, with independent indigenous and Pentecostal/charismatic churches, movements, and ministries leading the way in this dominance. In their spirituality, these are waves and streams of Christianity that emphasize the importance of the biblical Pentecost, the deployment of spiritual gifts in worship, and a general experience of the Holy Spirit as normative to the expression of Christianity. Thus, we can no longer talk about World Christianity, either in practice or in relation to the ecumenical movements of the 21st century, without accounting for the presence of Pentecostal/charismatic believers.
Effects of high‐pressure‐modified soy 11S globulin on the gel properties and water‐holding capacity of pork batter
Authors: Xie Jing‐jie , Zou Xiao‐Li , Li Yan‐ping , Kang Zhuang‐Li , Ma Han‐jun 
Published: February 2022

AbstractThe effects of high‐pressure‐modified soy 11S globulin (0.1, 200, and 400 MPa) on the gel properties, water‐holding capacity, and water mobility of pork batter were investigated. The high‐pressure‐modified soy 11S globulin significantly increased (P < 0.05) the emulsion stability, cooking yield, hardness, springiness, chewiness, resilience, cohesiveness, the a* and b* values, and the G′ and G′′ values of pork batter at 80 °C, compared with those of 0.1 MPa‐modified globulin. In contrast, the centrifugal loss and initial relaxation time of T2b, T21, and T22 significantly decreased (P < 0.05). Meanwhile, the microstructure was denser, and the voids were smaller and more uniform compared with those of 0.1 MPa‐modified globulin. In addition, the sample with 11S globulin modified at 400 MPa had the best water‐holding capacity, gel structure, and gel properties among the samples. Overall, the use of high‐pressure‐modified soy 11S globulin improved the gel properties and water‐holding capacity of pork batter, especially under 400 MPa.
Effects of shot peening on microstructure, thermal performance, and failure mechanism of thermal barrier coatings
Authors: Liu Guanxi , Shen Zaoyu , Huang Guanghong , He Limin , Mu Rende , Zhao Wenjun 
Published: February 2022

AbstractShot peening might be a potential technology to optimize the interface microstructure, plays a critical role on failure behaviors, of thermal barrier coatings (TBCs). It remains a significant challenge to understand the influence of shot peening on microstructure, oxidation resistance, and thermal shock life. In this work, the Y2O3‐stabilized ZrO2 TBCs have been deposited by EB‐PVD. The phase, microstructure, thermal performance, and failure mechanism of TBCs have been systemically investigated after shot peening. The shot peening process can improve the planeness of interface and reduce the formation of the cauliflower‐liked microstructure in TBCs. After shot peening, the TBC coatings exhibit relatively good isothermal oxidation resistance and high thermal shock life due to the optimization of TGO growth and the thermal stability. The phase transformation, TGO growth, and cracks extension might give rise to the failure of TBCs. This work might guide the investigation of the improvement of interface microstructure and failure behaviors.
Sonic application of one‐step self‐etch adhesive in composite restorations of non‐carious cervical lesions: A double‐blind randomized clinical trial
Authors: Hass Viviane , Cartagena Andres F. , Matos Thalita P. , de Souza Jullian J. , Toyotani Patricia E. , Reis Alessandra , Calixto Abraham L. , Loguercio Alessandro D. 
Published: February 2022

AbstractObjectivesTo evaluate the influence of the sonic device on the clinical performance of one‐step self‐etch adhesive systems in non‐carious cervical lesions (NCCLs) after 18 months.Materials and methodsForty patients participated in this study. Eighty restorations were assigned to two groups (n = 40): Sonic application and Manual application. After the adhesive application (iBond Self‐Etch, Kulzer, Hanau, Germany), NCCLs were restored using composite resin (Charisma, Kulzer, Hanau, Germany). The restorations were evaluated at baseline and after 18 months both according to the Word Dental Federation (FDI) and the United States Public Health Service (USPHS) criteria. Friedman repeated measures analysis of variance by rank and Wilcoxon test for significance in each pair were applied (α = 0.05).ResultsAfter 18 months, 38 patients were evaluated. Twenty‐three restorations were lost (19 for manual vs. 4 for sonic application). The retention rates (95% confidence interval) were 50% (CI 34.8%–65.1%) for manual application and 84.2% (CI 69.6%–92.6%) for sonic application (p < 0.05). Twelve restorations showed marginal staining (nine for manual vs. three for sonic application; FDI, p < 0.05) and nine some marginal discrepancy (seven for manual vs. two for sonic application; FDI, p < 0.05). No restorations showed postoperative sensitivity and caries recurrence at the time.ConclusionThe sonic application increases the retention rate of iBond Self‐Etch after 18 months of clinical evaluation in NCCLs.Clinical relevanceThe application of a simplified self‐etch adhesive (iBond Self‐Etch) associated to a sonic device seems to be an alternative to improve the clinical behavior in NCCLs.