bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetic Modelling and Sensitivity Analysis in Complex Chemical Reaction: From Computational Analysis to Industrial Scale
Authors: Sultan Faisal , Mustafa Soma , Shahzad Muhammad , Ali Mehboob 
Published: October 2022

Abstract
In this article, a two-route complex reaction mechanism is considered in detail. As in complex reaction we need to split reaction mechanism in different route to reduce the complexity of higher dimensional system. Firstly, measured the behavior of involved species in both routes. Secondly, SQEM technique is apply to both routes and distinctly measured initial approximation and trajectory solution. For the estimation of involved parameters and to understand the influence of parameters on involved species sensitivity analysis is applied and discussed graphically. Comparison of both route and common species is discussed and illustrated through figures.
The relationship between personality traits and job satisfaction of military nurses in the face of the Covid-19 crisis
Authors: shfiee Melika , Ahmadi Yazdan , Pishgooie Amir Hosein , Afaghi Effat , yaghoobi Faeze Bani 
Published: October 2022

Abstract
Background: Since December 2019, the prevalence of Covid-19-induced pneumonia has spread rapidly, placing nurses in heavy working conditions and affecting nurses' job satisfaction depends on many factors, one of which is the compatibility between personality and job
methods: This study was conducted to investigate the relationship between personality traits and job satisfaction of nurses working in selected AJA hospitals in the face of Covid-19 crisis.
Methods: In this descriptive-analytical study, 131 nurses working in Covid_19 involved wards in selected AJA hospitals were randomly selected.
Results: A total of 131 nurses who met the inclusion criteria were randomly selected. Job satisfaction is associated with personality traits of neuroticism, pleasantness and conscientiousness with P <0.005 and the level of job satisfaction with the average is 67.9% and the average job satisfaction of nurses working in selected AJA hospitals in the corona crisis is 47.35. . Also, nurses in all personality traits with 90.1% in neurotic personality traits, with 91.6% in extroverted personality traits, with 96.2% in flexible personality traits, with 96.2% in pleasant personality traits and with 94.7% The percentages in the conscientious personality trait are at level 2.
Conclusion: This study showed that there is a significant relationship between job satisfaction and personality traits of neuroticism, pleasantness and conscientiousness in Covid_19 crisis and personality traits can predict nurses' job satisfaction. Also, nurses' job satisfaction in the Corona crisis is at a moderate level, and most nurses are in the 5-factor personality traits at level 2 of these personality traits.
Human Umbilical Cord Derived Mesenchymal Stromal Cells for Treatment of Steroid-resistant and Therapy-refractory III-IV Acute Gastrointestinal Graft-versus-host Disease: An Open-label, Single-center, Self-control and Phase I/II Study
Authors: Niu Jingwen , Li Yuhang , Xu Chen , Sheng Hongxia , Tian Chong , Ning Hongmei , Hu Jiangwei , Chen Jianlin , Li Botao , Wang Jun , Lou Xiao , Liu Na , Su Yongfeng , Sun Yao , Qiao Zhuoqing , wang Lei , zhang Yu , Lan Sanchun , Xie Jing , Ren Jing , Chen Hu , Zhang Bin , Hu Liangding 
Published: October 2022

Abstract
Background: Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. First-line treatment of aGVHD is corticosteroid. Second-line therapy mainly comprises immunosuppressants. However, ∼ 25% of the patients have a steroid-resistant and therapy-refractory disease, which is associated with a very poor prognosis. An alternative therapy option for steroid-refractory and therapy-refractory aGVHD is the use of mesenchymal stromal cells (MSCs). Here, we report the results of 88 patients with grade III-IV aGVHD treated with human umbilical cord derived mesenchymal stromal cells (UC-MSC).
Methods: There were 18 children and 70 adults with grade III/ IV aGVHD (82% grade IV). These patients were either resistant to steroids or refractory to 1–5 additional immunosuppressants. UC-MSCs were transfused at a median dose of 1 × 106 cells/kg with a median of 4 times (range, 1 to 16).
Results: Median time between the onset of aGVHD and the first infusion of UC-MSC was 7 days (range, 3–88). The day 28 overall response rate was 51.14%, of these, 24 patients (27.27%) showed complete remission (CR), 21 (23.86%) showed partial remission (PR). The estimated survival probability at 100 days was 43.3%. And after a median follow-up of 66 months (26–122 months), the survival rate was approximately 33% (29/88). Patients developed acute gastrointestinal (GI) tract and liver GVHD showed worse overall response in day 28 than patients only with acute GI GVHD (21% vs. 58%; p= 0.037). No patient had severe side effects.
Conclusions: These results suggest that UC-MSC treatment was safe and effective in children and adults, and should be considered for treating steroid-refractory aGVHD.
Trial registration: ClinicalTrials: NCT01754454. Registered 21 December 2012 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT01754454?cond=msc+gvhd&draw=2&rank=8
Generic workflow of groundwater flow simulations in geologically complicated domains with millions of unstructured grids
Authors: Liou Tai-Sheng , Huang Sung-Yang , Lin Chao-Yan , Huang Ting-Wei , Chung Chuan-Wei , Hsieh Pei-Shan , Lin Cheng-Kuo 
Published: October 2022

AbstractNumerical groundwater flow simulation involves manual and tedious pre-processing and post-processing procedures. Hence, this study developed a systematic and efficient workflow to alleviate model buildup and data-processing burdens, allowing researchers to focus on the application aspects of simulation results. This highly automatic workflow allows researchers to execute three-dimensional groundwater flow simulations in sites with complex hydrogeological conditions. Processes in the workflow are formed as a trilogy: building a hydrogeological conceptual model, generating a site-specific unstructured mesh and specifying simulation conditions, and executing the simulation and post-processing results. The workflow feasibility has been demonstrated by simulating the three-component (water, brine, and air) fluid flow in Huayu Islet, the only andesitic island of the basaltic Penghu archipelago, using TOUGH3 (Transport Of Unsaturated Groundwater and Heat version 3) and its EOS7 (Equation Of State #7) fluid module. Our self-developed mesh generator can produce a locally refined unstructured mesh with millions of grid cells that can capture the essential geological features of Huayu. It was found that, of the three scenarios considered, only the one using a fine mesh coupled with a two-phase Dirichlet boundary condition at the top surface could obtain a physically meaningful bowl-shaped fresh water and brine interface and reasonable transport pathway characteristics. In summary, the developed workflow serves as a practical methodology to authentically characterize the hydrogeologic mechanisms of a site with complicated geology.
Smart hospital at home management for disabled elderly:A scoping review
Authors: Lu Yixin , Zhang Yan , Tian Yutong 
Published: October 2022

Abstract
Background
Smart hospital at home(HaH) have become a potential solution to the medical service needs of patients at home, but little is known about their application effects in the disabled elderly. It is necessary to map HaH management models and describe their forms, content, strategies, and evaluation indicators.
Methods
A scoping review was conducted based on the framework from Arksey and O’Malley. PubMed，Web of Science，Wangfang，CNKI，VIP and OpenGrey were searched until June 30,2022. Mapping existing the smart HaH management for the disabled elderly, including form, content, strategy, and evaluation.
Results
There were a total of 8 included studies，which focused on the following issues: The forms of management covering: mobile medical and telemedicine;The content covering clinical consultation, establishment of patient health records, guidance on equipment use, and alarm management; Strategy covering the formation of multidisciplinary teams, clarification of team members' responsibilities, comprehensive assessment before bed admission, and dynamic grade assessment throughout the process; Evaluation covering patient health outcomes, smart medical dependence, patient satisfaction evaluation, management program compliance and feasibility;
Conclusions
Smart HaH management presents comprehensive, holistic, targeted, and dynamic, and is relatively consistent in terms of management form, content, and strategy characteristics, and has achieved positive application effects. However, there is still a lack of high-quality research data and standardized and unified management evaluation criteria, and there is an urgent need to conduct a multi-center, large-sample study of smart HaH management programs for the disabled elderly.
Stereotactical normalization with multiple templates representative of normal and Parkinson-typical reduction of striatal uptake improves the discriminative power of automatic semi-quantitative analysis in dopamine transporter SPECT
Authors: Apostolova Ivayla , Schiebler Tassilo , Lange Catharina , Mathies Franziska Lara , Lehnert Wencke , Klutmann Susanne , Buchert Ralph 
Published: October 2022

Abstract
Background
The specific binding ratio (SBR) of 123I-FP-CIT in the putamen is widely used to support the interpretation of dopamine transporter (DAT) SPECT. Automatic methods for computation of the putamen SBR often include stereotactical normalization of the individual DAT-SPECT image to an anatomical standard space. This study compared using a single 123I-FP-CIT template image as target for stereotactical normalization versus multiple templates representative of normal and different levels of Parkinson-typical reduction of striatal 123I-FP-CIT uptake.
Methods
1702 clinical 123I-FP-CIT SPECT images were stereotactically normalized (affine) to the anatomical space of the Montreal Neurological Institute (MNI) with SPM12 either using a single custom-made 123I-FP-CIT template representative of normal striatal uptake or using eight different templates representative of normal and different levels of Parkinson-typical reduction of striatal FP-CIT uptake with and without attenuation and scatter correction. In the latter case, SPM finds the linear combination of the multiple templates that best matches the patient’s image. The putamen SBR was obtained using hottest voxels analysis in large unilateral regions-of-interest predefined in MNI space. The histogram of the putamen SBR in the whole sample was fitted by the sum of two Gaussians. The power to differentiate between reduced and normal SBR was estimated by the effect size of the distance between the two Gaussians computed as the differences between their mean values scaled to their pooled standard deviation.
Results
The effect size of the distance between the two Gaussians was 3.83 with the single template versus 3.96 with multiple templates for stereotactical normalization.
Conclusions
Multiple templates representative of normal and different levels of Parkinson-typical reduction for stereotactical normalization of DAT-SPECT might provide improved separation between normal and reduced putamen SBR that could result in slightly improved power for the detection of nigrostriatal degeneration.
A Solution for a Fundamental Problem of 3D Inference based on 2D Representations
Authors: Nguyen An 
Published: October 2022

Abstract
3D inference from monocular vision using neural networks is an important research area of computer vision. Applications of the research area are various with many solutions being proposed and have shown remarkable performance. Despite the fact that many efforts have been invested, there are still unanswered questions and some of them are fundamental. In this paper, I discuss a fundamental problem and propose a solution for its important special case.
Testing an attachment- and trauma-informed intervention approach for parents and young children after interparental violence: Protocol for a randomized controlled trial
Authors: Asdonk Sabine van der , Kesarlal Ashwina R. , Schuengel Carlo , Draaisma Nina , de Roos Carlijn , Zuidgeest Karine , Rippe Ralph C.A. , Alink Lenneke R.A. 
Published: October 2022

Abstract
Background: Interparental violence has persistent adverse effects on victimized parents and children. Young children, including infants and toddlers, are at particular risk to develop long-lasting negative outcomes, and yet specific evidence on effective intervention approaches for this vulnerable group is still lacking. This study will test the effectiveness of an attachment- and trauma-informed intervention approach in a sample of parent-child dyads who have experienced severe interparental violence. We test the individual and combined effects of two interventions: 1) ‘Nederlandse Interventie Kortdurend op Atypisch oudergedrag’ (NIKA; Dutch, Short-term Intervention focused on Atypical parenting behavior) aimed at improving the attachment relationship, and 2) eye movement desensitization and reprocessing (EMDR) therapy aimed at reducing parental post-traumatic stress disorder (PTSD) symptoms.
Methods: This study uses a multicenter randomized controlled design across multiple domestic violence shelters in the Netherlands. We aim to recruit 150 parent-child dyads with children aged between 0.5-6 years old. The study design consists of two phases. During the first phase for testing the effect of NIKA only, eligible dyads are randomly allocated to either NIKA or a waitlist usual care group. A pre-test is conducted prior to the treatment period and a post-test takes place directly afterwards (six weeks after the pre-test). Phase 2 follows directly for testing the effects of EMDR and the combination of NIKA and EMDR. Parents who report clinical PTSD symptoms are randomly allocated to either EMDR therapy or a waitlist usual care group. Parents who do not report clinical PTSD symptoms only receive care as usual. Six weeks later, a post-test of phase 2 is conducted for all participating dyads. Primary study outcomes are disrupted parenting behavior, sensitive parenting behavior, and parental PTSD symptoms. Secondary study outcomes include PTSD symptoms and behavioral and emotional problems of the child.
Discussion: This study will inform and enhance the clinical field by providing new insights regarding effective treatment combinations for traumatized parents and their young children after interparental violence.
Trial registration: Netherlands Trial Register (NTR): NL9179, Registered 7 January 2021, https://trialsearch.who.int/Trial2.aspx?TrialID=NL9179.
Integrated Metagenomic and Metabolomic Analyses of the Effects of Total Flavonoids of Rhizoma Drynariae on Reducing Ovariectomized-Induced Osteoporosis by Regulating Gut Microbiota and Related Metabolites
Authors: Li Qiuyue , Fang Shengjie , Chu Xuelei , Zhu Jia , Song Qinghui , Wei Xu , Wang Chaolu , Hou Chengzhi 
Published: October 2022

Abstract
Ethnopharmacological relevance:
Total flavonoids of Rhizoma Drynariae (TFRD), an important component extracted from the dried rhizome of Drynaria roosii Nakaike [Polypodiaceae]. TFRD has been widely used in China to treat osteoporosis (OP). However, the specific molecular mechanism of TFRD against OP has not been fully clarified.
Aim of the study:
The aim of this study was to further elucidate molecular mechanism of TFRD for treating OP based on metagenomic and metabolomic analyses.
Materials and methods:
In this study, hematoxylin-eosin (H&E) staining, micro computed tomography (micro-CT) and bone mineral density (BMD) analysis were used to observe pharmacological effects of TFRD against ovariectomized (OVX)-induced OP. Subsequently, multiomics analysis including metagenomics, untargeted and short chain fatty acids (SCFAs) metabolomics were carried out to identify whether the anti-osteoporosis mechanism of TFRD correlated with gut microbiota and related metabolites.
Results:
TFRD could improve the microstructure and density of trabecular bone in OVX rats. 17 differential species, which mainly from Akkermansia, Bacteroides, and Phascolarctobacteriumgenus, 14 related differential metabolites and acetic acid in SCFAs were significantly altered by OVX and reversed by TFRD. Furthermore, according to results of untargeted metabolomics analysis, it was found several metabolic pathways such as phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis and so on might play an important role in TFRD against OP. In order to further study the relationship between gut microbiota and related metabolites, spearman correlation analysis was used, and showed that gut microbiota such as Akkermansia muciniphila might be closely related to several metabolites and metabolic pathways.
Conclusions:
TFRD treatment could reduce the effects of OVX-induced OP by altering community composition and abundance of gut microbiota, regulating metabolites and SCFAs. It was speculated that the gut microbiota especially Akkermansia muciniphila and related metabolites might play an important role in TFRD against OP, and deserve further study by follow-up experiment. This conclusion provides new theoretical support for mechanism research of TFRD against OP.
Articular void sign on MRI in intra-articular distal radius fracture patients
Authors: Shibuya Ryoichi 
Published: October 2022

Abstract
Introduction: The purposes of this study are 1) to investigate whether MRI can detect ischemic changes in the subchondral bone and intra-articular fibrosis, 2) to investigate the relationship between MR imaging and wrist function, and 3) to investigate the compatibility of MR imaging and simple radiographic imaging in patients with intra-articular distal radius fracture treated using volar locking plate. Materials and methods: The plain radiographs, CT scans, and MRI findings of 27 patients were examined. The mean follow-up was 2 years (1 year − 3 years and 6 months). The range of motion of the wrist joint was evaluated as % arc, which is the ratio of the range of motion to that on the healthy side, expressed as a percentage. Results: In 27 patients, there were 6 type C1, 3 C2, and 18 C3 fractures. The mean step measured on plain radiographs was 0.4 ± 0.7 mm (range, 0 to 2 mm), and that on T1-weighted MR image was 0.6 ± 0.9 mm (range 0 to 3 mm). Comminuted central impaction fractures were observed in 9 patients on CT sections. The mean % arc was 88.1 ± 11.3% (range, 48.5 to 100%). Plain radiographs showed an area of sclerotic change in the subchondral bone in three patients. These three patients were consistent with those three patients whose % arc was smaller than the standard deviation. In two of the three patients, the area corresponding to this sclerotic area was a homogenic low intensity area on the T1-wegited MR images. Nevertheless this area consists of components with unspecified shape and intensity on T2-wegited MR images These areas were tentatively designated as “articular void”. Conclusions: This articular void was considered to include necrotic bone, fibrous tissue and suggested to be one of a cause of impairment of joint function.
Regression analysis and variable selection to determine the key subduction-zone parameters that determine the maximum earthquake magnitude
Authors: Nakao Atsushi , Kuwatani Tatsu , Ueki Kenta , Yoshida Kenta , Yutani Taku , Hino Hideitsu , Akaho Shotaro 
Published: October 2022

Abstract
Large variations in the maximum earthquake magnitude (Mmax) have been observed among the world’s subduction zones. There is still no universal relationship between Mmax and a given subduction-zone parameter, such as plate age, plate dip angle, or plate velocity, which suggests that multiple parameters control Mmax. Here we conduct exhaustive variable selections that are based on three evaluation criteria; leave-one-out cross-validation errors (LOOCVE), Akaike information criterion (AIC), and Bayesian information criterion (BIC) to determine the combination of subduction-zone parameters that best explains Mmax. Multiple linear regression analyses are applied using 18 subduction-zone parameters as potential candidates for the explanatory variables of Mmax. The minimum BIC is obtained when five variables (trench sediment thickness, existence of an accretionary prism, upper-plate crustal thickness, bending radius of the subducting oceanic plate, and trench depth) are selected as explanatory variables; each variable contributes positively to Mmax. Minimum LOOCVE and AIC values are obtained when eight variables (the five parameters for BIC, plus the along-strike plate convergence rate, age of the subducting plate, and maximum depth of the subducting plate) are selected. Our selection of the trench sediment thickness and plate bending radius contributing to Mmax is consistent with previous studies. The results show that increasing upper-plate crustal thickness results in a large Mmax. In addition to smoothing the subducting-plate interface via subducted sediments, along-dip extension of the crustal area along the convergent plate boundary would be important for generating a large earthquake.
Linkage and association mapping of ovule number per ovary (ON) in oilseed rape (Brassica napus L.)
Authors: Ali Ahmad , Li Wenhui , Zhang Hui , Wang Hao , Pengfei Wang , Jiao Yushun , Zhao Chenqi , Yang Guangsheng , Hong Dengfeng 
Published: October 2022

Abstract
Ovule number (ON) produced during flower development determines the maximum number of seeds per silique and thereby affects crop productivity; however, the genetic control of ON remains poorly understood in oilseed rape (Brassica napus). In this study, we genetically dissected the ON variations in a double haploid population (DH) and in diverse inbred accessions by linkage mapping and genome-wide association analysis. Phenotypic analysis in six environments showed that ON displayed normal distribution in both populations with the broad-sense heritability of 0.861 (DH population) and 0.930 (natural population). Linkage mapping identified 5 QTLs related to ON, including qON-A03, qON-A07, qON-A07-2, qON-A10, and qON-C06. Genome-wide association studies (GWAS) revealed 214, 48 and 40 significant single nucleotide polymorphisms (SNPs) by individually using the single-locus model GLM and the multiple-locus model MrMLM and FASTMrMLM. The phenotypic variation explained (PVE) by these QTLs and SNPs ranged from 2.00-17.40% and 5.03–7.33%, respectively. Integration of the results from both strategies identified four consensus genomic regions associated with ON from the Chr A03, A07, and A10. Our results preliminarily resolved the genetic basis of ON and provides useful molecular markers for plant yield improvement in B. napus.