bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution
Authors: Yang Wenjuan , Xie Shuangfeng , Li Yiqing , Wang Jieyu , Xiao Jie , Huang Kezhi , Wang Xiuju , Wu Yudan , Ma Liping , Nie Danian 
Published: September 2022

Abstract
Lymphoma relapse is very common in clinical work, but lineage switch at relapse is rare. Although some cases have reported acute lymphocytic leukemia (ALL) switch to acute myeloid leukemia (AML) or myeloid sarcoma upon relapse, phenotype switch seldom occurs in other types of lymphoma. Here we report six cases with lineage switch from lymphoma to myeloid neoplasms. In our cohort, three cases were mantle cell lymphoma (MCL), and the other three cases were T-cell lymphoblastic lymphoma (T-LBL), B-cell lymphoblastic lymphoma (B-LBL), and diffuse large B-cell lymphoma (DLBCL) at the initial diagnosis. When linage switch occurred, most cases were AML M5 phenotypes, and only one case was myelodysplastic syndrome (MDS) phenotype. 11q23/mixed-lineage leukemia (MLL) rearrangement was negative in all cases. Although intensive therapy and stem cell transplantation have been applied in most cases, the poor outcome cannot be reversed. Therefore, we found that lineage switch could occur not only from ALL to AML or vice versa, but also from MCL or DLBCL to AML. Moreover, the incidence of MLL rearrangement in lineage switch is lower in adult hematologic malignancies as compared with pediatric patients.
The crystal structure of 3,5-bis(propan-2-yl)-1H-pyrazol-4-amine, C9H17N3
Authors: Fujisawa Kiyoshi , Ageishi Keigo , Okano Mitsuki , Tiekink Edward R. T. 
Published: September 2022

Abstract
C9H17N3, monoclinic, P21/c (no. 14), a = 9.5601(3) Å, b = 9.5210(3) Å, c = 10.7651(3) Å, β = 94.564(3)°, V = 976.75(5) Å3, Z = 4, Rgt
(F) = 0.0432, wRref
(F
2) = 0.1223, T = 178(2) K.
The crystal structure of nitroxyl-κ
N-{hydridotris(3-trifluoromethyl-5-methylpyrazolyl-1-yl-κN
3)borato}nickel(II), C15H13BF9N7NiO
Authors: Fujisawa Kiyoshi , Kataoka Taisei , Terashima Kohei , Tiekink Edward R. T. 
Published: September 2022

Abstract
C15H13BF9N7NiO, orthorhombic, Pnma (no. 62), a = 17.8513(3) Å, b = 13.3869(2) Å, c = 8.5944(2) Å, V = 2053.83(7) Å3, Z = 4, Rgt
(F) = 0.0235, wRref
(F
2) = 0.0690, T = 124(2) K.
Religion und Geschlecht als diskursive, intersektionale, performative Kategorien der Wissensproduktion
Authors: Auga Ulrike E. 
Published: September 2022

Abstract
Dieser Beitrag gibt einen Überblick der zentralen postsäkularen Debatten im Kontext der Schnittstelle von Religions- und Geschlechterforschung. Aus postkolonialer, postsäkularer und Geschlechter-/queerer Perspektive ist eine eigene Epistemologie für die Untersuchung von ‚Religion‘ und ‚Geschlecht‘ entwickelt worden. Die Methode der Intersektionalität wird für die Analyse von ‚Religion‘ überarbeitet. Die Kategorie ‚Religion‘, die in der Geschlechterforschung häufig vernachlässigt oder essentialisiert wird, wird in Abhängigkeit von ‚Geschlecht‘, ‚Sexualität‘, ‚Race‘, ‚Nation‘, ‚Klasse‘, ‚Spezies‘ etc. weiterdiskutiert und als diskursive, intersektionale, performative Kategorie elaboriert. ‚Geschlecht‘ und ‚Religion‘ werden als diskursive, intersektionale, performative Kategorien der Wissensproduktion erarbeitet. Diese Kategorien werden nicht nur dekonstruiert und deessentialisiert, sondern konsequent denaturalisiert und desidentifiziert, um epistemische Gewalt zu überkommen. Weiterhin kann Religion – konzeptualisiert als Wissenskategorie – nicht nur zum individuellen, sondern auch zum kollektiven Handlungsmachtgewinn beisteuern. Zudem werden Weiterentwicklungen feministischer Theorie im postsäkularen Kontext und in der queer-feministisch-materialistischen Theoriebildung und Religion diskutiert.
Are Serbian and English listeners insensitive to lexical pitch accents in Serbian?
Authors: Nikolić Dušan , Winters Stephen 
Published: September 2022

AbstractThe paper investigated possible perceptual insensitivity effects in the perception of lexical pitch accents by native and non-native listeners, that is, by Serbian and English listeners, respectively. The objective of the study was to explore which word-prosodic categories listeners used when they were required to contrast and recall sequences of lexical pitch accents. To that effect, Serbian and English listeners performed a Sequence Recall Task (SRT) in which they contrasted pairs of non-words with different Serbian lexical pitch accent types, and recalled the sequences of these non-words under different memory load conditions. Listeners’ answers were coded correct and incorrect and the accuracy scores between the groups were compared and analyzed. Both groups had almost identical levels of accuracy and they performed well above chance level on each contrast. Neither group exhibited any effects of perceptual insensitivity to lexical pitch accents. English (non-native) listeners did not differ in their performance from native Serbian listeners, which, contrary to what previous research suggested, implied that one’s native language word-prosodic category inventory did not preclude the encoding of non-native word-prosodic categories. Instead, non-native listeners were capable of deploying different prosodic resources such as post-lexical pitch accents to recall the sequences.
Der russische Überfall auf die Ukraine – eine militärische Lageanalyse
Authors: Rosemann Alexander 
Published: September 2022

Kurzfassung
Der russische Überfall auf die Ukraine ist ein epochales Ereignis, das die europäische Sicherheitslandschaft grundlegend verändert. Eine Analyse der militärischen Lage ist daher wichtig. Sie stellt den Überfall in seinen verschiedenen Phasen anhand der verfügbaren Informationen dar. Russlands ursprüngliche Erwartungen bezüglich eines raschen Erfolgs seiner Militäroperation haben sich schon kurz nach Beginn der Operation als falsch herausgestellt. Die ukrainischen Streitkräfte haben erfolgreich den russischen Angriffen widerstanden und intelligent die zahlreichen Schwächen der russischen Operationsplanung und taktischen Umsetzung ausnutzen können. Mitte April erfolgte eine strategische Umorientierung der russischen Operationsplanung, was zu einer Konzentration aller Kräfte auf den Donbas geführt hat. Trotz kleinerer Landgewinne können die russischen Kräfte keinen wirklichen Durchbruch erzielen und haben mit erheblichen Problemen zu kämpfen. Beachtlich sind auch das schlechte Abschneiden der russischen Luftwaffe und die Verluste, die Russlands Marine einstecken musste. In den kommenden Monaten wird es darauf ankommen, dass die westlichen Staaten die Ukraine mit schwerem Material unterstützen.
The Aspects of International Communication: Strategic Partnership of Ukraine and Turkey
Authors: Mishchenko Alla , Shevel Inna , Likarchuk Daria , Shevchenko Maryna 
Published: September 2022

Abstract
The article aims to analyze the geopolitical, conflict-related, and strategic interests of Ukraine realized within the framework of the South vector of the state geopolitics through rational and pragmatic cooperation with the trans-regional leader of the region – Turkey. The study aims to identify priority areas of cooperation between Ukraine and Turkey in the Black Sea region for the effective implementation of geostrategic interests of Ukraine and the regularity of development of political defense systems during crises and modern military-political conflicts. The interdisciplinary approach and methods of analytical and comparative analysis made it possible to study and examine the evolution of the value-ideological loads which dominate the implementation of Eastern or Western geopolitical vectors. The necessity to consider political, social, and conflict-related imbalances and integration constraints revealed the pragmatic direction of equidistant foreign policy implementation in a three-dimensional format. This format involves an alternative vector of bilateral cooperation with Turkey and a joint position, which will ensure accelerated development of Ukraine and help avoid pressure from the European Union and the Russian Federation. The defensive type of geostrategy serves as a common denominator in cooperation between countries, providing more substantial interaction at the level of experience exchange on military operations, military-political conflicts in Syria and the Eastern regions of Ukraine, solving problems with separatist regions, implementing programs for refugees and internally displaced persons, developing a parity promotion of integration of Turkey and Ukraine into the EU.
Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in aDrosophilaModel of ALS
Authors: Karagas Nicholas E. , Gupta Richa , Rastegari Elham , Tan Kai Li , Leung Ho Hang , Bellen Hugo J. , Venkatachalam Kartik , Wong Ching-On 
Published: September 2022

Mutations in the gene encoding vesicle-associated membrane protein B (VAPB) cause a familial form of amyotrophic lateral sclerosis (ALS). Expression of an ALS-related variant ofvapb(vapbP58S) inDrosophilamotor neurons results in morphologic changes at the larval neuromuscular junction (NMJ) characterized by the appearance of fewer, but larger, presynaptic boutons. Although diminished microtubule stability is known to underlie these morphologic changes, a mechanism for the loss of presynaptic microtubules has been lacking. By studying flies of both sexes, we demonstrate the suppression ofvapbP58S-induced changes in NMJ morphology by either a loss of endoplasmic reticulum (ER) Ca2+release channels or the inhibition Ca2+/calmodulin (CaM)-activated kinase II (CaMKII). These data suggest that decreased stability of presynaptic microtubules atvapbP58SNMJs results from hyperactivation of CaMKII because of elevated cytosolic [Ca2+]. We attribute the Ca2+dyshomeostasis to delayed extrusion of cytosolic Ca2+. Suggesting that this defect in Ca2+extrusion arose from an insufficient response to the bioenergetic demand of neural activity, depolarization-induced mitochondrial ATP production was diminished invapbP58Sneurons. These findings point to bioenergetic dysfunction as a potential cause for the synaptic defects invapbP58S-expressing motor neurons.SIGNIFICANCE STATEMENTWhether the synchrony between the rates of ATP production and demand is lost in degenerating neurons remains poorly understood. We report that expression of a gene equivalent to an amyotrophic lateral sclerosis (ALS)-causing variant of vesicle-associated membrane protein B (VAPB) in fly neurons decouples mitochondrial ATP production from neuronal activity. Consequently, levels of ATP in mutant neurons are unable to keep up with the bioenergetic burden of neuronal activity. Reduced rate of Ca2+extrusion, which could result from insufficient energy to power Ca2+ATPases, results in the accumulation of residual Ca2+in mutant neurons and leads to alterations in synaptic vesicle (SV) release and synapse development. These findings suggest that synaptic defects in a model of ALS arise from the loss of activity-induced ATP production.
Pressure Based Control For A Variable Speed Diesel Engine Driven Pump Controller
Authors: Mohd Jamil Muhammad Arieffuddin , Mohd Romlay Fadhlur Rahman , Muhamad Khairul Fikri , Abdul Samat Shamsudin , Ishak Ismayuzri 
Published: September 2022

Chemical cleaning is a process that utilizes chemical as a cleaning medium to remove unwanted contaminants. The chemical cleaning process may involve with the use of pump to circulate the chemical during cleaning process. The pump for the cleaning process can be driven by electrical or internal combustion engine. This paper presents the development of a variable speed diesel engine driven pump controller for chemical cleaning application. The controller utilize proportional control method as the control scheme. The variable speed diesel engine driven pump system includes a diesel engine coupled with centifugal pump, a controller, pressure sensor, and battery powerpacks. All the components are mounted on a skid platform for the ease of use as a system. Proportional control method were used in order to get the critical gain parameter to compute PID parameter gains using Ziegler Nichols tuning method
11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing's disease
Authors: Nowotny Hanna F , Braun Leah , Vogel Frederick , Bidlingmaier Martin , Reincke Martin , Tschaidse Lea , Auer Matthias K , Lottspeich Christian , Wudy Stefan A , Hartmann Michaela F , Hawley James , Adaway Joanne E , Keevil Brian , Schilbach Katharina , Reisch Nicole 
Published: September 2022

Abstract

Background
Symptoms of hyperandrogenism are common in patients with Cushing's disease (CD), yet they are not sufficiently explained by androgen concentrations. In this study, we analyzed the contribution of 11-oxygenated C19 steroids (11oxC19) to hyperandrogenemia in female patients with CD.

Methods
We assessed saliva day profiles in females with CD pre (n = 23) and post (n = 13) successful transsphenoidal surgery, 26 female controls, 5 females with CD treated with metyrapone and 5 treated with osilodrostat for cortisol, cortisone, androstenedione (A4), 11-hydroxyandrostenedione (11OHA4), testosterone (TS), 11-ketotestosterone (11KT), as well as metabolites of classic and 11-oxygenated androgens in 24-h urine. In addition, morning baseline levels of gonadotropins and estradiol, sex hormone-binding globulin, cortisol and dehydroepiandrosterone sulfate (DHEAS) in serum and adrenocorticotrophic hormone in plasma in patients and controls were investigated.

Results
Treatment-naïve females with CD showed a significantly elevated area under the curve of 11OHA4 and 11KT in saliva throughout the day compared to controls (11OHA4 mean rank difference (mrd) 18.13, P = 0.0002; 11KT mrd 17.42; P = 0.0005), whereas A4, TS and DHEAS were comparable to controls. Gonadotropin concentrations were normal in all patients with CD. After transsphenoidal surgery, 11oxC19 and their metabolites dropped significantly in saliva (11OHA4 P &lt; 0.0001; 11KT P = 0.0010) and urine (11-oxo-androsterone P = 0.0011; 11-hydroxy-androsterone P &lt; 0.0001), treatment with osilodrostat and metyrapone efficaciously blocked 11oxC19 synthesis.

Conclusion
Hyperandrogenemia in CD is predominantly caused by excess of 11oxC19 steroids.
Follicular and hormonal changes after estrous synchronization in bottlenose dolphins
Authors: Montano Gisele , Clough Pat , Schmitt Todd , Davis Michelle , Steinman Karen , O’Brien Justine , Robeck Todd 
Published: September 2022

To gain more knowledge about the influence of hormone regulation on follicle development, ovarian ultrasounds were performed, and urinary hormone profiles were determined in ovulating and non-ovulating female bottlenose dolphins (n  = 15) following estrus synchronization with altrenogest. Ovarian ultrasounds were conducted daily, post-synchronization to describe follicular recruitment in relation to the endocrine profile. Follicle sizes were grouped into very small (VSM), small (SM), medium (MD) and large (LG). In ovulating females, two follicular waves were identified, and follicular deviation toward establishing a dominant follicle only occurred during the second wave. For non-ovulating females, only the first wave was observed. For all urinary hormones, the non-ovulating group presented significantly lower concentrations of follicle-stimulating hormone (uFSH), luteinizing hormone (uLH), estrone conjugates (uE1-C) and estriol (uE3) but similar progestagen and cortisol concentrations compared to the ovulating group. Concentrations of uE1-C and uE3 and the numbers of MD and LG follicles significantly (P < 0.05) increased, while uFSH concentrations significantly (P < 0.05) decreased as ovulation approached. Urinary LH significantly increased concurrently with increasing numbers of LG follicles and decreasing numbers of SM follicles. The characterization of follicular development and its relationship with hormone assessment complements our understanding of follicular recruitment post-synchronization in bottlenose dolphins and provides new information concerning differences between ovulating and non-ovulating females in response to an estrous synchronization protocol.

Lay summary
Many species of fresh and saltwater dolphins and porpoises are facing increasing pressure for food and habitats due to human activities. One of the primary aspects that can be affected by such activities is reproduction. The bottlenose dolphin has been successfully bred in zoos and aquariums for at least 70 years, and they can be trained for several voluntary behaviors that enable medical examinations. Therefore, they represent a unique resource for research and understanding of normal dolphin reproduction. In this research, voluntary ultrasound exams and urine samples from 15 female dolphins were used to describe changes in their ovaries. The resulting descriptions and comparisons provide insight into the unique ovarian physiology of bottlenose dolphins and into the differences between animals after treatment. This information adds to the body of knowledge which one day may be used for developing advanced reproductive techniques to help preserve endangered species of dolphins.
Sustainability Agreements and Social Norms
Authors: Inderst Roman , Rhiel Felix , Thomas Stefan 
Published: September 2022

Abstract
Spurred by recent publications of National Competition Agencies, there is an ongoing debate on whether and, if so, how competition law and its enforcement shall give due consideration to concerns of sustainability, notably environmental sustainability. With respect to horizontal agreements, we define circumstances where sustainability concerns may indeed warrant a somewhat modified approach for the assessment of consumer welfare implications of a market related measure. We posit a feedback-effect on the willingness-to-pay for more sustainable products when a horizontal agreement leads other consumers to change their behavior. The underlying reason for this stems from the non-use value associated with sustainability and from its relation to social norms. In such scenarios, there can be a first-mover disadvantage for a firm who would unilaterally introduce a more sustainable product, which may justify horizontal cooperation. More generally, we argue that the construction of counterfactuals, in particular over a longer time horizon, may prove particularly challenging in a competitive assessment of sustainability claims. We also document the feedback effect arising from other consumers’ behavior with data that the Dutch Competition Authority gathered for its “Chicken of Tomorrow” case.
Rückstellungen für kartellrechtliche Risiken nach HGB und IFRS
Authors: Hennrichs Joachim , Pöschke Moritz 
Published: September 2022

Zusammenfassung
Kartellrechtliche Risiken spielen in der Wirtschaftspraxis eine immer größere Rolle. Die Bildung und Auflösung entsprechender Rückstellungen in den Abschlüssen der betroffenen Unternehmen kann erhebliche Ergebniseffekte haben und damit auch die Ausschüttungsfähigkeit (Dividendenpolitik) betreffen. Im April 2019 bildete etwa BMW ertragswirksam eine Rückstellung von 1,4 Mrd. € für von der EU-Kommission vermutete illegale Kartellabsprachen. Der folgende Beitrag vermittelt einen systematischen Überblick über den gesamten Themenkomplex – und zwar mit Blick auf Abschlüsse nach HGB wie IFRS. Nach einer Darstellung der einschlägigen Risiken, für die aus Sicht der betroffenen Unternehmen eine Rückstellungsbildung in Betracht kommt, werden die Voraussetzungen für die Bildung und Bewertung von Rückstellungen eingehend untersucht.
Will sustainability and environmental considerations be the next big hit for shaping the application of Article 102 TFEU?
Authors: Lindenberg Helen 
Published: September 2022

Abstract
The German Federal Cartel Office’s (FCO) proceedings against Facebook have made big waves. The FCO used antitrust instruments, but based its action on a violation of data protection regulations. This action could serve as a blueprint for the violation of other non-competitive regulations, such as the violation of sustainability and environmental goals. This paper explores whether and how specifically Article 102 TFEU can serve in implementing sustainability and environmental considerations.
Optimizing Antibiotic Treatment of Skin Infections in Pediatric Emergency and Urgent Care Centers
Authors: Wiltrakis Susan May , Jaggi Preeti , Lu Lydia , Jain Shabnam 
Published: September 2022

OBJECTIVES
The objective was to optimize antibiotic choice and duration for uncomplicated skin/soft tissue infections (SSTIs) discharged from pediatric emergency departments (EDs) and urgent cares (UCs).

METHODS
Pediatric patients aged 0 to 18 years discharged from 3 pediatric EDs and 8 UCs with a diagnosis of uncomplicated SSTIs were included. Optimal treatment was defined as 5 days of cephalexin for nonpurulent SSTIs and 7 days of clindamycin or trimethoprim/sulfamethoxazole for purulent SSTIs. Exclusion criteria included erysipelas, folliculitis, felon, impetigo, lymphangitis, paronychia, perianal abscess, phlegmon, preseptal or orbital cellulitis, and cephalosporin allergy. Baseline data were collected from January 2018 to June 2019. Quality improvement (QI) interventions began July 2019 with a revised SSTI guideline, discharge order set, and maintenance of certification (MOC) QI project. MOC participants received 3 education sessions, monthly group feedback, and individual scorecards. Balancing measures included return visits within 10 days requiring escalation of care. Data were monitored through March 2021.

RESULTS
In total, 9306 SSTIs were included. The MOC QI project included 50 ED and UC physicians (27% of eligible physicians). For purulent SSTI, optimal antibiotic choice, plus duration, increased from a baseline median of 28% to 64%. For nonpurulent SSTI, optimal antibiotic choice, plus duration, increased from a median of 2% to 43%. MOC participants had greater improvement than non-MOC providers (P &lt; .010). Return visits did not significantly change pre- to postintervention, remaining &lt;2%.

CONCLUSIONS
We improved optimal choice and reduced duration of antibiotic treatment of outpatient SSTIs. MOC participation was associated with greater improvement and was sustained after the intervention period.
A 14-Year-Old Female With Chest Mass, Shortness of Breath, and Hypertension
Authors: Kirkman Kelsey , Prudowsky Zachary D. , Shah Shweta , Demmler Harrison Gail , Rao Seema , Cohen Adam 
Published: September 2022

BACKGROUND
A previously healthy 14-year-old girl was evaluated in the emergency department (ED) with 2 months of shortness of breath and fatigue.

METHODS
She initially presented to her primary pediatrician, where a complete blood count was only significant for mild anemia, thyroid function tests were normal, and a chest x-ray revealed a chest mass. This prompted her primary pediatrician to order a computed tomography scan and refer to the ED.

RESULTS
Her computed tomography scan confirmed a mediastinal mass versus necrotic lymphadenopathy. Her initial physical exam was unremarkable, except for hypertension. From the ED, she was admitted to the pediatric hospital medicine service. Infectious disease, oncology, and nephrology services were consulted to guide diagnostic evaluation.

CONCLUSIONS
Eventually, during her hospitalization, further history and workup led to a definitive diagnosis.