bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting Large Explosions With Machine Learning Models Trained on Synthetic Infrasound Data
Authors: Witsil Alex , Fee David , Dickey Joshua , Peña Raúl , Waxler Roger , Blom Philip 
Published: May 2022

AbstractExplosions produce low‐frequency acoustic (infrasound) waves capable of propagating globally, but the spatio‐temporal variability of the atmosphere makes detecting events difficult. Machine learning (ML) is well‐suited to identify the subtle and nonlinear patterns in explosion infrasound signals, but a previous lack of ground‐truth data inhibited training of generalized models. We introduce a physics‐based method that propagates infrasound sources through realistic atmospheres to create 28,000 synthetic events, which are used to train ML classifiers. A simple artificial neural network and modern temporal convolutional network discriminate synthetic events from background noise with >90% accuracy and, more importantly, successfully identify the majority of real‐world explosion signals recorded during the Humming Road Runner experiment. ML models trained entirely on physics‐based synthetics advance explosion detection capabilities and make ML more viable to related fields lacking training data.
Very Early Postseismic Deformation Following the 2015 Mw 8.3 Illapel Earthquake, Chile Revealed From Kinematic GPS
Authors: Liu Kai , Geng Jianghui , Wen Yangmao , Ortega‐Culaciati Francisco , Comte Diana 
Published: May 2022

AbstractThe very early phase of postseismic deformation spanning the first few hours is difficult to capture using daily Global Positioning System (GPS) and interferometric synthetic aperture radar. Using kinematic GPS instead, we analyzed the surface deformation that occurred during the first 3 days immediately after the 2015 Mw 8.3 Illapel earthquake. Particularly, the displacements at station PFRJ reached 2–3 cm during the first 2 hr, and grew to 6.1 cm after 12 hr from the origin time. We hence imaged the afterslip evolution by inverting kinematic GPS and found that the very early afterslip was mainly concentrated around the hypocenter. The early afterslip evolved to be distributed along three main slip zones along the strike, which was complementary to the coseismic slip zones in space. The location of aftershocks was highly consistent with the spatiotemporal evolution of early afterslip, suggesting that the occurrence of aftershocks may be influenced by afterslip in the very early postseismic period.
The Response of Geomagnetic Daily Variation and Ionospheric Currents to the Annular Solar Eclipse on 21 June 2020
Authors: Liu Xiaocan , Chen Junjie , Han Peng , Lei Jiuhou , Dang Tong , Huang Fuqing , Chen Huaran , Jiao Liguo , Ma Xinxin , Tu Jiyao , Lei Yu , Zhao Junhao 
Published: May 2022

AbstractIn this study, we examined the response of geomagnetic daily variation and ionospheric currents to the solar annular eclipse that passed through China at 10:00–17:30 LT on 21 June 2020. We utilized geomagnetic field data obtained from the Geomagnetic Network Center of China, Institute of Geophysics, China Earthquake Administration and International Real‐time Magnetic Observatory Network, which extend from middle latitudes to equatorial regions in China and surrounding areas. It is found that the eclipse obscuration reduces the intensity of geomagnetic daily variation at most stations as compared with the 5‐quiet‐day average. The response of geomagnetic daily variation to the solar eclipse depends on local time and latitude. In most shadowed areas of the eclipse, there is a reduction of northward (southward) component of the meridional magnetic daily field (ΔX) below (above) ∼30° magnetic latitudes. The solar eclipse can also induce a decrease of the zonal magnetic field variation (ΔY). Meanwhile, we observed that the solar eclipse reduces the intensity of vertical geomagnetic component (ΔZ) at the stations around the early afternoon aside the eclipse totality. In general, these geomagnetic responses imply that the solar eclipse can reduce the ionospheric solar quiet (Sq) current system. These ionospheric currents and ground geomagnetic field disturbances during the solar eclipse are also verified by a global physical model. The simulation demonstrates that the ionospheric currents in the southern hemisphere, where the solar eclipse does not cover, also have a weak response. Overall, the ionospheric current disturbance induced by the solar eclipse shows a counter‐Sq pattern.
Mapping the Brightness of Ganymede's Ultraviolet Aurora Using Hubble Space Telescope Observations
Authors: Marzok A. , Schlegel S. , Saur J. , Roth L. , Grodent D. , Strobel D. F. , Retherford K. D. 
Published: May 2022

AbstractWe analyze Hubble Space Telescope observations of Ganymede made with the Space Telescope Imaging Spectrograph between 1998 and 2017 to generate a brightness map of Ganymede's oxygen emission at 1,356 Å. Our Mercator projected map demonstrates that the brightness along Ganymede's northern and southern auroral ovals strongly varies with longitude. To quantify this variation around Ganymede, we investigate the brightness averaged over 36°‐wide longitude corridors centered around the sub‐Jovian (0° W), leading (90° W), anti‐Jovian (180° W), and trailing (270° W) central longitudes. In the northern hemisphere, the brightness of the auroral oval is 3.7 ± 0.4 times lower in the sub‐Jovian and anti‐Jovian corridors compared to the trailing and leading corridors. The southern oval is overall brighter than the northern oval, and only 2.5 ± 0.2 times fainter on the sub‐ and anti‐Jovian corridors compared to the trailing and leading corridors. This demonstrates that Ganymede's auroral ovals are strongly structured in auroral crescents on the leading side (plasma downstream side) and on the trailing side (plasma upstream side). We also find that the brightness is not symmetric with respect to the 270° meridian, but shifted by ∼20° towards the Jovian‐facing hemisphere. Our map will be useful for subsequent studies to understand the processes that generate the aurora in Ganymede's non‐rotationally driven, sub‐Alfvénic magnetosphere.
Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging
Authors: Li Xin , Wang Jiaqiang , Wang LeYun , Gao Yuanxu , Feng Guihai , Li Gen , Zou Jun , Yu Meixin , Li Yu Fei , Liu Chao , Yuan Xue Wei , Zhao Ling , Ouyang Hong , Zhu Jian-Kang , Li Wei , Zhou Qi , Zhang Kang 
Published: May 2022

AbstractEpigenetic alterations and metabolic dysfunction are two hallmarks of aging. However, the mechanism of how their interaction regulates aging, particularly in mammals, remains largely unknown. Here we show ELOVL fatty acid elongase 2 (Elovl2), a gene whose epigenetic alterations are most highly correlated with age prediction, contributes to aging by regulating lipid metabolism. We applied artificial intelligence to predict the protein structure of ELOVL2 and the interaction with its substrate. Impaired Elovl2 function disturbs lipid synthesis with increased endoplasmic reticulum stress and mitochondrial dysfunction, leading to key aging phenotypes at both cellular and physiological level. Furthermore, restoration of mitochondrial activity can rescue age-related macular degeneration (AMD) phenotypes induced by Elovl2 deficiency in human retinal pigmental epithelial (RPE) cells; this indicates a conservative mechanism in both human and mouse. Taken together, we revealed an epigenetic-metabolism axis contributing to aging and illustrate the power of an AI-based approach in structure-function studies.
SOX17-mediated MALAT1-miR-199a-HIF1α axis confers sensitivity in esophageal squamous cell carcinoma cells to radiotherapy
Authors: Yun Yifei , Zhang Yutong , Xu Qiqi , Ou Yao , Zhou Xifa , Lu Zhonghua 
Published: May 2022

AbstractRadiotherapy is a main modality of esophageal squamous cell carcinoma (ESCC) treatment, while radioresistance largely limits the effect of this therapy. Evidence exists reporting that SOX17 may sensitize ESCC cells to irradiation, but the downstream mechanism remains poorly understood. Therefore, we attempt to explore the molecular basis of SOX17 effect on radioresistance in ESCC. The SOX17 expression was measured in ESCC tissues and cells, followed by evaluation of its relationship with patient survival. The fractionated irradiation-induced irradiation-resistant cell line KYSE150R was subjected to gain- and loss-of function studies to explore the effect of SOX17 and downstream effectors MALAT1, miR-199a, and HIF1α on the malignant phenotypes of ESCC. The interaction among these factors was explained using ChIP, dual luciferase reporter, RNA pull-down and RIP assays. Further, the in vivo effect of SOX17 on ESCC irradiation tolerance was assessed in nude mice. SOX17 was underexpressed in ESCC tissues and cells, which was negatively correlated with the prognosis of patients with ESCC. Besides, SOX17 inhibited irradiation tolerance of ESCC cells by suppressing MALAT1 transcription. Notably, MALAT1 acted as miR-199a sponge and thereby enhanced HIF1α expression. Moreover, SOX17 reduced the irradiation tolerance of ESCC cells by reducing HIF1α expression via the MALAT1-miR-199a axis, and attenuated tumor formation in nude mice. Our results indicate that SOX17 can impede the radioresistance of ESCC cells through the MALAT1-miR-199a-HIF1α axis, in support of further research for ESCC radiotherapy.
Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming
Authors: Bedi Yudhishtar S. , Wang Haiqing , Thomas Kara N. , Basel Alison , Prunier Julien , Robert Claude , Golding Michael C. 
Published: May 2022

AbstractUsing a mouse model, studies by our group reveal that paternal preconception alcohol intake affects offspring fetal-placental growth, with long-lasting consequences on adult metabolism. Here, we tested the hypothesis that chronic preconception male alcohol exposure impacts histone enrichment in sperm and that these changes are associated with altered developmental programming in the placenta. Using chromatin immunoprecipitation, we find alcohol-induced increases in sperm histone H3 lysine 4 trimethylation (H3K4me3) that map to promoters and presumptive enhancer regions enriched in genes driving neurogenesis and craniofacial development. Given the colocalization of H3K4me3 with the chromatin binding factor CTCF across both sperm and embryos, we next examined CTCF localization in the placenta. We find global changes in CTCF binding within placentae derived from the male offspring of alcohol-exposed sires. Furthermore, altered CTCF localization correlates with dysregulated gene expression across multiple gene clusters; however, these transcriptional changes only occur in male offspring. Finally, we identified a correlation between genomic regions exhibiting alcohol-induced increases in sperm H3K4me3 and increased CTCF binding in male placentae. Collectively, our analysis demonstrates that the chromatin landscape of sperm is sensitive to chronic alcohol exposure and that a subset of these affected regions exhibits increased placental CTCF enrichment.
External validation of a triage tool for predicting cardiac arrest in the emergency department
Authors: Sun Jen-Tang , Chang Chih-Chun , Lu Tsung-Chien , Lin Jasper Chia-Cheng , Wang Chih-Hung , Fang Cheng-Chung , Huang Chien-Hua , Chen Wen-Jone , Tsai Chu-Lin 
Published: May 2022

AbstractEarly recognition and prevention comprise the first ring of the Chain of Survival for in-hospital cardiac arrest (IHCA). We previously developed and internally validated an emergency department (ED) triage tool, Emergency Department In-hospital Cardiac Arrest Score (EDICAS), for predicting ED-based IHCA. We aimed to externally validate this novel tool in another ED population. This retrospective cohort study used electronic clinical warehouse data from a tertiary medical center with approximately 130,000 ED visits per year. We retrieved data from 268,208 ED visits over a 2-year period. We selected one ED visit per person and excluded out-of-hospital cardiac arrest or children. Patient demographics and computerized triage information were retrieved, and the EDICAS was calculated to predict the ED-based IHCA. A total of 145,557 adult ED patients were included. Of them, 240 (0.16%) developed IHCA. The EDICAS showed excellent discrimination with an area under the receiver operating characteristic (AUROC) of 0.88. The AUROC of the EDICAS outperformed those of other early warning scores (0.80 for Modified Early Warning Score [MEWS] and 0.83 for Rapid Emergency Medicine Score [REMS]) in the same ED population. An EDICAS of 6 or above (i.e., high-risk patients) corresponded to a sensitivity of 33%, a specificity of 97%, and a positive likelihood ratio of 12.2. In conclusion, we externally validated a tool for predicting imminent IHCA in the ED and demonstrated its superior performance over other early warning scores. The real-world impact of the EDICAS warning system with appropriate interventions would require a future prospective study.
Effect of heat exposure on the growth and developmental competence of bovine oocytes derived from early antral follicles
Authors: Kawano Kohei , Sakaguchi Kenichiro , Madalitso Chelenga , Ninpetch Nattapong , Kobayashi Shintaro , Furukawa Eri , Yanagawa Yojiro , Katagiri Seiji 
Published: May 2022

AbstractIn dairy cows, low fertility caused by summer heat stress continues into the cooler autumn season. This can be caused by impaired oocyte quality in small growing follicles during summer. Here, we subjected oocyte–cumulus–granulosa complexes (OCGCs) derived from early antral follicles (0.5–1 mm) to in vitro growth (IVG) culture under two different temperature settings (the control and heat shock groups), and evaluated effects of heat exposure on growth and developmental competence of oocytes, factors affecting the developmental competence of oocytes (steroidogenesis of granulosa cells, oxidative stress in oocytes, and cell-to-cell communication between oocytes and somatic cells). Oocyte diameters after culture were smaller in the heat shock group. Although nuclear maturation and cleavage rates were similar between the groups, blastocyst rates were lower in the heat shock group (0.0%) than in the control group (27.7%), and reduced glutathione (GSH) levels in oocytes were lower in the heat shock group. Supplementation of cysteine, which stimulates GSH synthesis, increased GSH level and improved blastocyst rate of heat shocked oocytes (27.9%). These results suggest that heat exposure impairs the growth and developmental competence of oocytes in early antral follicles through GSH depletion, which can induce low fertility during summer and the following autumn.
Assessing the impacts of agricultural drought (SPI/SPEI) on maize and wheat yields across Hungary
Authors: Mohammed Safwan , Alsafadi Karam , Enaruvbe Glory O. , Bashir Bashar , Elbeltagi Ahmed , Széles Adrienn , Alsalman Abdullah , Harsanyi Endre 
Published: May 2022

AbstractThis study examined the physical properties of agricultural drought (i.e., intensity, duration, and severity) in Hungary from 1961 to 2010 based on the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI). The study analyzed the interaction between drought and crop yield for maize and wheat using standardized yield residual series (SYRS), and the crop-drought resilient factor (CDRF). The results of both SPI and SPEI (-3, -6) showed that the western part of Hungary has significantly more prone to agricultural drought than the eastern part of the country. Drought frequency analysis reveals that the eastern, northern, and central parts of Hungary were the most affected regions. Drought analysis also showed that drought was particularly severe in Hungary during 1970–1973, 1990–1995, 2000–2003, and 2007. The yield of maize was more adversely affected than wheat especially in the western and southern regions of Hungary (1961–2010). In general, maize and wheat yields were severely non-resilient (CDRF < 0.8) in the central and western part of the country. The results suggest that drought events are a threat to the attainment of the second Sustainable Development Goals (SDG-2). Therefore, to ensure food security in Hungary and in other parts of the world, drought resistant crop varieties need to be developed to mitigate the adverse effects of climate change on agricultural production.
Groundwater irrigation reduces overall poverty but increases socioeconomic vulnerability in a semiarid region of southern India
Authors: Fischer Chloé , Aubron Claire , Trouvé Aurélie , Sekhar Muddu , Ruiz Laurent 
Published: May 2022

AbstractThe development of irrigation is generally considered an efficient way to reduce poverty in rural areas, although its impact on the inequality between farmers is more debated. In fact, assessing the impact of water management on different categories of farmers requires resituating it within the different dimensions of the local socio-technical context. We tested this hypothesis in a semi-arid area in Karnataka, South India, where groundwater irrigation was introduced five decades ago. Using the conceptual framework of comparative agriculture, based on farmers’ interviews, we built a farm typology, traced the trajectories of farm types over the last decades and assessed their current technical and economic performances. Our results show that the differentiation of farm trajectories since the 1950s has been linked with the development of groundwater irrigation, interplaying with their initial assets, and the evolution of the national and local contexts. We highlight the mechanisms by which irrigation indeed reduces poverty but engenders fragilities, particularly for poor households, whose situation was aggravated by the depletion of water resources over the last two decades. Finally, this extensive understanding of the agrarian context allowed us to formulate and assess the potential of different ways forward, including irrigation technology, change in cropping or livestock systems, land tenure, and value added distribution. As such, this analysis would be of major interest to policy makers involved in reforming the agricultural context for better agricultural water management.
Comparative transcriptome profiles of human dental pulp stem cells from maxillary and mandibular teeth
Authors: Faruangsaeng Thira , Thaweesapphitak Sermporn , Khamwachirapitak Chompak , Porntaveetus Thantrira , Shotelersuk Vorasuk 
Published: May 2022

AbstractThe molecular control of tooth development is different between the maxilla and mandible, contributing to different tooth shapes and locations; however, whether this difference occurs in human permanent teeth is unknown. The aim of this study was to investigate and compare the transcriptome profiles of permanent maxillary and mandibular posterior teeth. Ten participants who had a pair of opposing premolars or molars extracted were recruited. The RNA obtained from cultured dental pulp stem cells underwent RNA-sequencing and qRT-PCR. The transcriptome profiles of two opposing premolar pairs and two molar pairs demonstrated that the upper premolars, lower premolars, upper molars, and lower molars expressed the same top-ranked genes, comprising FN1, COL1A1, COL1A2, ACTB, and EEFIA1, which are involved in extracellular matrix organization, immune system, signal transduction, hemostasis, and vesicle-mediated transport. Comparative transcriptome analyses of each/combined tooth pairs demonstrated that PITX1 was the only gene with different expression levels between upper and lower posterior teeth. PITX1 exhibited a 64-fold and 116-fold higher expression level in lower teeth compared with their upper premolars and molars, respectively. These differences were confirmed by qRT-PCR. Taken together, this study, for the first time, reveals that PITX1 is expressed significantly higher in mandibular posterior teeth compared with maxillary posterior teeth. The difference is more evident in the molars compared with premolars and consistent with its expression pattern in mouse developing teeth. We demonstrate that differences in lower versus upper teeth gene expression during odontogenesis occur in permanent teeth and suggest that these differences should be considered in molecular studies of dental pulp stem cells. Our findings pave the way to develop a more precise treatment in regenerative dentistry such as gene-based therapies for dentin/pulp regeneration and regeneration of different tooth types.
Long-term seed burial reveals differences in the seed-banking strategies of naturalized and invasive alien herbs
Authors: Moravcová Lenka , Carta Angelino , Pyšek Petr , Skálová Hana , Gioria Margherita 
Published: May 2022

AbstractSoil seed viability and germinability dynamics can have a major influence on the establishment and spread of plants introduced beyond their native distribution range. Yet, we lack information on how temporal variability in these traits could affect the invasion process. To address this issue, we conducted an 8-year seed burial experiment examining seed viability and germinability dynamics for 21 invasive and 38 naturalized herbs in the Czech Republic. Seeds of most naturalized and invasive species persisted in the soil for several years. However, naturalized herbs exhibited greater seed longevity, on average, than invasive ones. Phylogenetic logistic models showed that seed viability (but not germinability) dynamics were significantly related to the invasion status of the study species. Seed viability declined earlier and more sharply in invasive species, and the probability of finding viable seeds of invasive species by the end of the experiment was low. Our findings suggest that invasive herbs might take advantage of high seed viability in the years immediately after dispersal, while naturalized species benefit from extended seed viability over time. These differences, however, are not sufficiently strong to explain the invasiveness of the species examined.
Midfrontal theta power encodes the value of haptic delay
Authors: Alsuradi Haneen , Park Wanjoo , Eid Mohamad 
Published: May 2022

AbstractThe use of haptic technologies in modern life scenarios is becoming the new normal particularly in rehabilitation, medical training, and entertainment applications. An evident challenge in haptic telepresence systems is the delay in haptic information. How humans perceive delayed visual and audio information has been extensively studied, however, the same for haptically delayed environments remains largely unknown. Here, we develop a visuo-haptic experimental setting that simulates pick and place task and involves continuous haptic feedback stimulation with four possible haptic delay levels. The setting is built using a haptic device and a computer screen. We use electroencephalography (EEG) to study the neural correlates that could be used to identify the amount of the experienced haptic delay. EEG data were collected from 34 participants. Results revealed that midfrontal theta oscillation plays a pivotal role in quantifying the amount of haptic delay while parietal alpha showed a significant modulation that encodes the presence of haptic delay. Based on the available literature, these results suggest that the amount of haptic delay is proportional to the neural activation that is associated with conflict detection and resolution as well as for multi-sensory divided attention.