bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seawater signatures of Ordovician climate and environment
Authors: Young Seth A. , Edwards Cole T. , Ainsaar Leho , Lindskog Anders , Saltzman Matthew R. 
Published: December 2022

Abstract
Tracking climatic changes throughout the Ordovician is crucial to a better understanding of the coevolution of life and environment on Earth. Ordovician climate fluctuations have been the subject of a vigorous and productive body of work over the past two decades. Here we present a synthesis of studies that have focused on reconstructing Ordovician climate and environment via direct geochemical proxy datasets and/or numerical modelling approaches. Many new insights have been gained on potential causes of events: the timing and potential causes of the major radiation of Ordovician marine life, changes in weathering and the transition from a greenhouse-to-icehouse state, and cooling and (de)oxygenation during the end-Ordovician Glaciation. Marked improvements in sample resolution/distribution of traditional palaeotemperature (oxygen isotopes), palaeoredox (sulfur isotopes) and weathering proxy records (strontium and neodymium isotopes), as well as the development of new palaeoenvironmental proxies (e.g. clumped, uranium, molybdenum and thallium isotopes; iodine, iron, trace metal geochemistry), have led to better constraints on Ordovician climate and environment. These recent works have led to a more nuanced understanding of the Ordovician Earth System, which allows the global community to focus future efforts on answering remaining questions regarding palaeoclimate and environment, as well as embark upon new investigations.
Targeting Nitric Oxide: Say NO to Metastasis
Authors: Reddy Tejaswini P. , Glynn Sharon A. , Billiar Timothy R. , Wink David A. , Chang Jenny C. 
Published: December 2022

Abstract
Utilizing targeted therapies capable of reducing cancer metastasis, targeting chemoresistant and self-renewing cancer stem cells, and augmenting the efficacy of systemic chemo/radiotherapies is vital to minimize cancer-associated mortality. Targeting nitric oxide synthase (NOS), a protein within the tumor microenvironment, has gained interest as a promising therapeutic strategy to reduce metastatic capacity and augment the efficacy of chemo/radiotherapies in various solid malignancies. Our review highlights the influence of nitric oxide (NO) in tumor progression and cancer metastasis, as well as promising preclinical studies that evaluated NOS inhibitors as anticancer therapies. Lastly, we highlight the prospects and outstanding challenges of using NOS inhibitors in the clinical setting.
Is There a Place for Temozolomide plus Nivolumab among Neuroendocrine Neoplasms?
Authors: Velez Maria A. , Garon Edward B. 
Published: December 2022

SummaryImmune checkpoint inhibitors have revolutionized the treatment of multiple solid malignancies, but their role in the treatment of neuroendocrine neoplasms (NEN) is unclear. The accompanying article reports on a study combining the programmed cell death (PD-1) inhibitor nivolumab with the alkylating agent temozolomide in patients with advanced NENs.See related article by Owen et al., p. 731
Conceptualizing Confidence: A Multisited Qualitative Analysis in a Severe Weather Context
Authors: Henderson Jen , Spinney Jennifer , Demuth Julie L. 
Published: December 2022

Abstract
Confidence is a concept important to weather prediction, shaping how risk information is created, shared, understood, and acted upon. For forecasters in the National Weather Service (NWS) and their partners in public safety, confidence is central to their work, appearing frequently during their decision support services. While confidence has been examined in a variety of literatures, it is often addressed simplistically or as one of many variables in a study. It is rarely the object of study in and of itself, even less so in a naturalistic setting like an operational environment. To build a more robust knowledge of confidence and its many dimensions, we conducted a multisited ethnography of three interrelated sites central to tornado prediction and information dissemination, leading up to and during a cool-season tornado event. In partnership with collaborators from the NWS and emergency management, we simultaneously deployed to a National Center, a local Weather Forecast Office, and an emergency management office. This article explicates confidence from multiple social science theories, considering the scientific, data-based roots of confidence, as well as its affective, relational, and procedural origins. Our results show that confidence emerges in varied and complex ways and at different scales. Confidence can indicate one’s assessment of evidence and agreement (or lack) of it, beliefs about partners’ future behavior based on past experiences, and ritual interactions between offices that create patterned expectations. We argue for a more robust interdisciplinary analysis of confidence given how it shapes weather-related policies and practices, technologies, and communication strategies.
Sky View Factor and Screening Impacts on the Forecast Accuracy of Road Surface Temperatures in Finland
Authors: Karsisto Virve , Horttanainen Matti 
Published: December 2022

Abstract
Forecasting road conditions is important, especially in areas with wintry conditions and rapidly changing weather. Accurate forecasts help authorities keep roads safe and optimize maintenance. Considering local features is important when making the forecast because the road surface temperature can vary significantly depending on the road surroundings. For example, in a shadowed location, the road surface temperature can be significantly lower than in open surroundings. A road weather model developed at the Finnish Meteorological Institute is used to forecast the road surface temperature and road conditions. However, the model still assumes open road surroundings. In this study, sky view factor and screening are included in the model, and their effects on the forecast road surface temperature is tested. Road surface temperature hindcasts were performed for 23 selected road weather stations in Finland for three winter periods (October–March) between 2018 and 2021. The results were location dependent, and even changing the lane had a great effect on the verification results in some cases. At best, the screening considerably decreased RMSE values during the day. However, there were many cases in which the screening increased RMSE. In general, the used shadowing algorithm increased the already negative bias during the day. Nevertheless, there were also cases in which the shadowing algorithm improved the bias, especially in February. During the night, the sky view factor made the forecast generally a little warmer, which often slightly decreased the negative bias in the forecast.

Significance Statement
The screening caused by objects surrounding a road has a great effect on the road surface temperature. Recently, a screening algorithm was added to the Finnish Meteorological Institute’s model that forecasts road conditions. The purpose of this study was to test how the algorithm affects the accuracy of road surface temperature forecasts. According to the results, the screening greatly improved the forecast accuracy in some cases. However, in some cases, the screening made the already overly cold forecast even colder. The study has increased our understanding of the effect of shadowing in the modeled road surface temperatures and helps to create more accurate forecasts in the future.
Evidence for Shifting Cognitive Strategies when Icons Appear in Unexpected Locations
Authors: Ericson Jonathan D. , Albert William S. 
Published: December 2022

Objective The present study examines the cognitive effects of placing icons in unexpected spatial locations within websites. Background Prior research has revealed evidence for cognitive conflict when web icons occur in unexpected locations (e.g., cart, top left), generally consistent with a dynamical systems models. Here, we compare the relative strength of evidence for both dual and dynamical systems models. Methods Participants clicked on icons located in either expected (e.g., cart, top right) or unexpected (e.g., cart, top left) locations while mouse trajectories were continuously recorded. Trajectories were classified according to prototypes associated with each cognitive model. The dynamical systems model predicts curved trajectories, while the dual-systems model predicts straight and change of mind trajectories. Results Trajectory classification revealed that curved trajectories increased (+11%), while straight and change of mind trajectories decreased (−12%) when target icons occurred in unexpected locations (p < .001). Conclusion Rather than employing a single cognitive strategy, users shift from a primarily dual-systems to dynamical systems strategy when icons occur in unexpected locations. Application Potential applications of this work include the assessment of cognitive impacts such as mental workload and cognitive conflict during real-time interaction with websites and other screen-based interfaces, personalization and adaptive interfaces based on an individual’s cognitive strategy, and data-driven A/B testing of alternative interface designs.
Do Sustainability Disclosures Lead to Opportunistic Behaviour? Empirical Evidence from India
Authors: Kumar Sunil , Mishra Poornima , Sharma Ashish 
Published: December 2022

The present study empirically examines the bi-directional relationship between sustainability disclosures and earnings quality under mandatory sustainability disclosures regime for India, a developing country. It considers both the qualitative and quantitative measurements of sustainability disclosures. Earlier research only explored such relationships assuming a unidirectional approach, under voluntary sustainability disclosure setting with quantitative measurements of sustainability disclosures for developed countries. The study employs the generalised method of moments (GMM) approach on selected listed companies for the period 2013–2019. The result shows a negative bi-directional relationship between sustainability disclosures quality and earnings quality which also hold when tested with an alternate earnings quality measure. The result confirms that firms focusing on sustainability disclosures will also be manipulating earnings because of opportunistic perspective. Also, firms manage earnings to use sustainability disclosures as their cover to protect themselves. The study offers theoretical contribution by empirically corroborating the agency theory based managerial opportunism hypothesis. It extends and validates the managerial opportunism hypothesis in a novel context and under mandatory sustainability disclosures setting. The findings offer strong policy implications to Indian regulators and other stakeholders regarding the unintended consequence of mandatory sustainability disclosures. JEL Codes: Q50, Q56, M48
Mechanical properties of additively printed, UV cured, continuous fiber unidirectional composites for multifunctional applications
Authors: Baur Jeffery W , Abbott Andrew C , Barnett Philip R , Tandon Gyaneshwar P , Furmanski Jevan , Stranberg Nathan A , Alvarado Tyler B 
Published: December 2022

This paper investigates the mechanical properties and microstructure of additively manufactured, continuous fiber reinforced composites made by the Continuous Fiber 3D Printing (CF3D®) process. We specifically investigate composites of GF-2, a high temperature thermosetting acrylic polymer, and T-1100, a high strength carbon fiber, with a 41.5% fiber volume fraction. The resulting composites have a longitudinal tensile modulus of 122 GPa and a strength of 1599 MPa, which is 89% and 55% of the theoretical value by rule of mixtures, respectively. This appears to be the highest strength additively manufactured composites to date, largely due to the high mechanical properties of the T-1100 fiber, low defects, and substantial fiber volume fraction. Comparable results are obtained for a cationic cure resin, CATPRO14. We optically measured the fiber–fiber contact surface area fraction of GF-2 and employing the unidirectional strength model of Karam to predict a strength efficiency of 0.6, which is in good agreement with mechanical estimate of 0.55. Comparing results with the efficiency factors of high fiber volume prepreg laminates, we determine the printing process yields composites with 88%–95% of the anticipated longitudinal modulus and 65%–70% of the anticipated longitudinal tensile strength of those processed by traditional methods. To extend the printing to multifunctional microvascular composites, we consider the mechanical implications of including sacrificial filaments of 100–300 μm within each tow. A modest decrease in longitudinal strength in proportion to the microchannel volume fraction is predicted, where the decrease is mainly attributed to the increased fiber-to-fiber interactions in more tightly packed tows.
Sebastián Lelio’s Una mujer fantástica: Intimate Citizenship, Trans Activism, and the Gender Identity Law in Chile
Authors: Miles Penny 
Published: December 2022

When Una mujer fantástica reached the height of Oscar success in March 2018, Chilean trans populations were fighting to secure legal recognition, and they were doing so at a time of political transition from a leftist to a rightist government. The film’s international success ensured that the gender identity bill remained on the table. Use of the concepts of intimate citizenship and frame resonance to analyze the social and political role of the film’s trans representation shows how they offer visual framing and visual resonance for Chilean activism. The protagonist’s story created a visual frame to reinforce trans activist claims at a key moment in the congressional debates as the soft power of the Oscars was brought to bear on them. Cuando Una mujer fantástica alcanzó la cima del éxito en los óscares de marzo de 2018, las poblaciones trans chilenas luchaban por asegurarse reconocimiento legal en un momento de transición política—el paso de un gobierno de izquierda a uno de derecha. El éxito internacional de la película aseguró que el proyecto de ley sobre identidad de género permaneciera sobre la mesa. El uso de los conceptos de ciudadanía íntima y resonancia de marco para analizar el rol social y político de la representación trans en la película muestra cómo esto nos brinda tanto encuadre como resonancia visual al activismo chileno. La historia de la protagonista generó un marco visual que refuerza las afirmaciones de activistas trans en un momento clave en los debates del Congreso, los cuales se vieron influenciado por el poder blando de los óscares.
Nasal monkeypox virus infection successfully treated with cidofovir in a patient newly diagnosed with HIV
Authors: Labate Laura , Brucci Giorgia , Ciccarese Giulia , Bruzzone Bianca , Ricucci Valentina , Stefanelli Federica , Delfino Emanuele , Taramasso Lucia , Bassetti Matteo , Di Biagio Antonio 
Published: December 2022

Monkeypox (MPXV) usually causes a mild and self-limited infection. To date there are no data about cidofovir for the treatment for MPXV in humans. We report a case of a 25 years-old Brazilian man with a concurrent diagnosis of acute HIV (human immunodeficiency virus) infection, primary syphilis and MPXV infection with a nasal lesion successfully treated with intravenous cidofovir.
Supply Chain Collaboration Components Enhancing Firm Performance of Manufacturers in Vietnam: Innovation Capability Moderation
Authors: Nguyen Nguyen Thi Duc , Mai Nguyen Thi Hoang 
Published: December 2022

This study aims to investigate the components of supply chain collaboration, their impacts on firm performance, and the moderation of innovation capability on the relationship between supply chain collaboration components and firm performance in the real world of manufacturing companies in Vietnam. A two-phase approach, including exploratory factor analysis and confirmatory factor analysis in structural equation modelling with the support of SPSS/AMOS 20 is conducted to verify the proposed hypotheses based on supply chain collaboration activities of 241 manufacturing firms in Vietnam under the extended resource-based view—capability-based approach—specifying innovation capability. The results indicate that six supply chain collaboration components—information sharing, goal congruence, joint knowledge creation, incentive alignment, resource sharing, and collaborative communication—have a significant impact on firm performance, while decision synchronisation has no statistically proven impact on firm performance. Particularly, collaborative communication has the greatest positive impact, and innovation capability can considerably alter the positive relationship between supply chain collaboration components and firm performance. Accordingly, manufacturing companies in Vietnam and their supply chain partners should strategically prioritise resources for supply chain collaboration activities and capitalise on potential networks to foster an inter-organizational learning-oriented culture for improving innovation capability and achieving firm performance.
Safety of Bivalirudin Combined with Ticagrelor in the Emergency PCI in Patients with Acute ST-Segment Elevation Myocardial Infarction
Authors: Wang Zheng-Dong , Chen Yu-Xiang , Liu Ming , Li Ping , Liang Xiang-Wen , Zhu Xian-Zhang , Xie Wen-Chao , Liao Wang 
Published: December 2022

Objective The present study aimed to investigate the application safety of bivalirudin combined with ticagrelor in the emergency percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Methods From October 1, 2018, to December 30, 2019, 210 patients with STEMI admitted to the Department of Cardiology who underwent emergency PCI were randomly divided into the bivalirudin group (group A, N = 105) and the unfractionated heparin group (group B, N = 105). Before the emergency PCI operation after admission, the loading dose of aspirin (300 mg) was given orally, and then 100 mg/d. At the same time, the loading dose of ticagrelor (180 mg) was administered orally, and then 90 mg/bid. The adverse events and the hemorrhage events 30 days after the operation were observed and recorded. Results There were five hemorrhage cases in the bivalirudin group, with one case of secondary hemorrhage and four cases of mild hemorrhage. There were 14 hemorrhages in the unfractionated heparin group with one case of secondary hemorrhage and thirteen cases of mild hemorrhage. In terms of mild hemorrhage, the hemorrhage rate in the bivalirudin group was significantly lower than that in the unfractionated heparin group (3.8% vs. 12.4%, P = 0.040). One patient died in the unfractionated heparin group, while no deaths occurred in the bivalirudin group during the thirty days of follow-up. No myocardial infarction, revascularization, or stroke occurred in the two groups within 30 days after the operation. Conclusion Compared with unfractionated heparin combined with ticagrelor in patients with STEMI undergoing emergency PCI treatment, bivalirudin combined with ticagrelor could significantly reduce the occurrence of mild hemorrhage events, and it would not increase the incidence of MACE during the 30 days of follow-up.
Use of a photoacoustic needle improves needle tip recognition in a video recording of simulated ultrasound-guided vascular access: A pilot study
Authors: Nakazawa Harumasa , Tokumine Joho , Lefor Alan Kawarai , Yamamoto Katsuya , Karasawa Hiroyuki , Shimazu Keisuke , Yorozu Tomoko 
Published: December 2022

Background: We developed a novel photoacoustic needle, which emits ultrasound produced by the photoacoustic effect. This study focused on the most common “pitfall” associated with placement during ultrasound-guided vascular access, which is misidentification of the needle tip. Methods: The study was conducted as a prospective cohort study using a questionnaire. The authors intentionally created two successful and one failed ultrasound-guided central venous catheterization videos using the photoacoustic needle on a simulator. Each of these three videos was then split into two movies for viewing, one with standard ultrasound images only and the second including the images from the photoacoustic needle, for a total of six movies. Results: Participants who were 18 anesthesiologists, 12 residents, and 10 medical students, watched each of the six movies and completed a survey whether the puncture was successful or not. In the results, there was a significant difference in the percentage of correct answers whether the movie depicted successful or failed puncture with and without the photoacoustic ultrasound ( p = 0.0001). Conclusion: The novel photoacoustic needle improved the ability to identify the needle tip on recorded videos. It may have efficacy to prevent serious mechanical complication during the ultrasound-guided vascular access in clinical practice.
Hemodialysis Arteriovenous Access Cosmesis Scale (AVACS): A new measure for vascular access
Authors: Yuo Theodore H , Kim Charles Y , Rajan Dheeraj K , Niyyar Vandana D , Murea Marianna , Dillavou Ellen D , Bream Jr Peter R , Dinwiddie Lesley C , Hohmann Stephen E , Woo Karen , Vachharajani Tushar , Roberts Cynthia , Gooden Christie , Wright George WJ , Hogan Andrew J , Ferko Nicole C , Kahle Erin , Clynes Diana , Lok Charmaine E 
Published: December 2022

Rationale and objective: This study aimed to develop a cosmesis scale to evaluate the cosmetic appearance of hemodialysis (HD) arteriovenous (AV) accesses from the perspective of the patient and clinician, which could be incorporated into clinical trials. Study design: Using a modified Delphi process, two AV access cosmesis scale (AVACS) components were developed in a four-round Delphi panel consisting of two surveys and two consensus meetings with two rounds of patient consultation. Setting and participants: The Delphi panel consisted of 15 voting members including five interventional or general nephrologists, five vascular surgeons, three interventional radiologists, and two vascular access nurse coordinators. Four patients experienced with vascular access were involved in patient question development. Analytical approach: For a component to be included in the AVACS, it had to meet the prespecified panel consensus agreement of ⩾70%. Results: The clinician component of the AVACS includes nine questions on the following AV access features: scarring, skin discoloration, aneurysm/pseudoaneurysms and megafistula appearance. The patient component includes six questions about future vascular access decisions, interference with work or leisure activities, clothing choices, self-consciousness or attractiveness, emotional impact, and overall appearance. Limitations: Delphi panel methods are subjective by design, but with expert clinical opinion are used to develop classification systems and outcome measures. The developed scale requires further validation testing but is available for clinical trial use. Conclusions: While safety and efficacy are the primary concerns when evaluating AV access for HD, cosmesis is an important component of the ESKD patient experience. The AVACS has been designed to assess this important domain; it can be used to facilitate patient care and education about vascular access choice and maintenance. AVACS can also be used to inform future research on developing new techniques for AV access creation and maintenance, particularly as relates to AV access cosmesis.