bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of STIM-Activated TRPC-ORAI Channels in Pulmonary
Hypertension Induced by Chronic Sustained and Intermittent Hypoxia
Authors: Castillo-Galán Sebastián , Arenas Germán A. , Iturriaga Rodrigo 
Published: March 2022

Abstract:
Sustained and intermittent hypoxia produce vasoconstriction, arterial remodeling, and hypertension
in the lung. Stromal interaction molecule (STIM)-activated transient receptor potential channels
(TRPC) and calcium release-activated calcium channel protein (ORAI) channels (STOC) play key roles
in the progression of pulmonary hypertension in pre-clinical models of animals subjected to sustained
and intermittent hypoxia. The available evidence supports the theory that oxidative stress and hypoxic
inducible factors upregulate and activate STIM-activated TRPC-ORAI Ca2+ channels, contributing to
the pulmonary remodeling and hypertension induced by sustained hypoxia. However, less is known
about the effects of oxidative stress and hypoxic inducible factors on the modulation of STIM-activated
TRPC-ORAI channels following chronic intermittent hypoxia. In this review, we examined the emerging
evidence supporting the theory that oxidative stress and hypoxic inducible factors induced by intermittent
hypoxia upregulate and activate STIM-activated TRPC-ORAI Ca2+ channels. In addition, we
used bioinformatics tools to search public databases for the genes involved in the upregulation of STIMactivated
TRPC-ORAI Ca2+ channels and compare the differential gene expression and biological processes
induced by intermittent and sustained hypoxia in lung cells.
Syncope Prediction Scores in the Emergency Department
Authors: Liu Tong , Liang Yan , Li Xiulian , Tse Gary , King Emma , Roever Leonardo , Li Guangping 
Published: March 2022

Abstract:
Syncope is a common clinical presentation defined as a transient loss of consciousness
(TLOC) due to cerebral hypoperfusion, characterized by a rapid onset, short duration, and spontaneous
complete recovery. Different clinical decision rules (CDRs) and risk stratification scores
have been developed to predict short- and long-term risks for adverse outcomes after syncope. The
central theme of these prediction systems is consistent with the ESC syncope guidelines. Initial assessment
according to the ESC guideline is essential until an optimal and well-validated risk score
is available. The focus should be accurate risk stratification to allow prevention of adverse outcomes
and optimize the use of limited healthcare resources. In this review article, we summarize
and critically appraise the evidence regarding the CDRs for patients presenting with syncope.
Factors Associated with Women Fertility in Bangladesh: Application on
Count Regression Models
Authors: Haq Iqramul , Hossain Md. Ismail , Saleheen Ahmed Abdus Saleh , Nayan Md. Iqbal Hossain , Afrin Tanjina , Talukder Ashis 
Published: March 2022

Background:
The current total fertility rate in Bangladesh is now 2.3 births per woman,
which is still above the replacement level of 2.1.

Objective:
The main objective of this study was to identify potential factors associated with fertility
transition in Bangladesh.

Methods:
This study applied several regression models to find the best-fitted model to determine
factors associated with the number of children ever-born in Bangladesh and utilize data from the
2019 Bangladesh Multiple Indicator Cluster Survey.

Results:
Based on the principles of the AIC, BIC, and Vuong tests, the best-fit model was the Hurdle-
Poisson regression model compared to other models. Findings based on the Hurdle Poisson regression
result revealed that the number of children increases with the increase of women’s age, but
the number of children declines if the education status of women as well as their delayed marriage
increases. Women who had secondary or higher education were less likely to have children than illiterate
women. Similarly, division, residential area, wealth index, women’s functional difficulties,
prenatal care, and migration have significantly influenced the number of children ever born.

Conclusion:
Based on the findings, the study suggests that fertility can be decreased by improving
female education, minimizing early marriage, and eliminating poverty for all ever-married women
who were particularly live in rural areas of the Chattogram and Sylhet divisions in Bangladesh.
Such steps would be the largest contribution to a future reduction in fertility rates in Bangladesh.
FDG-PET/CT Assessment of the Cerebral Protective Effects of Hydrogen
in Rabbits with Cardiac Arrest
Authors: Huang Guoqing , Li Xiangmin , Tang Yongxiang , Yao Zhengbin , Hu Shuo , Zhou Hui , Mo Xiaoye , She Changshou , Lu Xiaoqin 
Published: March 2022

Background:
Anatomical imaging methods and histological examinations have limited
clinical value for early monitoring of brain function damage after cardiac arrest (CA) in vivo.

Objective:
We aimed to assess the cerebral protective effects of hydrogen in rabbits with CA by using
fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT).

Methods:
Male rabbits were divided into the hydrogen-treated (n=6), control (n=6), and sham (n=3)
groups. Maximum standardized uptake values (SUVmax) were measured by FDG-PET/CT at baseline
and post-resuscitation. Blood Ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neuron-specific enolase
(NSE) were measured before and after the operation. After surgical euthanasia, brain tissues were
extracted for Nissl staining.

Results:
SUVmax values first decreased at 2 and 24 h after resuscitation before rising in the hydrogentreated
and control groups. SUVmax values in the frontal, occipital, and left temporal lobes and in the
whole brain were significantly different between the hydrogen and control groups at 2 and 24 h postresuscitation
(P<0.05). The neurological deficit scores at 24 and 48 h were lower in the hydrogentreated
group (P<0.05). At 24 h, the serum UCH-L1 and NSE levels were increased in the hydrogen
and control groups (P<0.05), but not in the sham group. At 48 and 72 h post-CA, the plasma UCH-L1
and NSE levels in the hydrogen and control groups gradually decreased. Neuronal damage was smaller
in the hydrogen group compared to the control group at 72 h.

Conclusion:
FDG-PET/CT could be used to monitor early cerebral damage, indicating a novel method
for evaluating the protective effects of hydrogen on the brain after CA.
An Insight of Clinical Evidence of Ayurveda Interventions in the Management
of COVID-19 Patients
Authors: Maideen Naina Mohamed Pakkir , Balasubramanian Rajkapoor , Manavalan Gobinath , Balasubramanian Kumar , Subramanian Nivedhitha , Murugesan Thirumal , Solaimalai Vasanth Kumar 
Published: March 2022

Background:
Coronavirus disease 2019 (COVID-19) was caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) and patients with COVID-19 may be treated with
traditional medicine like Ayurveda alone or in combination with standard allopathic treatment, as
Ayurveda is one of the oldest traditional medicinal systems followed by millions around the world.

Methods:
The literature was searched in databases such as LitCOVID, Google Scholar, Science Direct,
EBSCO, Scopus, Web of Science, EMBASE, and reference lists to identify articles relevant to the use
of Ayurvedic medicines in the management of COVID-19.

Results:
Several clinical studies have determined the efficacy of Ayurvedic medicines and formulations
in the management of patients with COVID-19.

Conclusion:
The Ayurvedic medicines and formulations with antiviral, antioxidant, anti-inflammatory,
and immunomodulatory properties could be used along with standard allopathic medicines to assist in
the earlier detection of virus, speedy recovery of patients with COVID-19, faster discharge from hospitals,
and the prevention of further deterioration.
Radioprotective Mechanisms of Arbutin: A Systematic Review
Authors: Sadeghinezhad Shima , Khodamoradi Ehsan , Diojan Loghman , Taeb Shahram , Najafi Masoud 
Published: March 2022

Purpose:
Efforts to produce radioprotective agents of high potential are appropriate
strategies for overcoming possible IR toxicity in organisms. The present research aims to evaluate
the signaling pathways and mechanisms through which arbutin exerts radioprotective effects on
organisms.

Methods:
The databases of PubMed, Web of Sciences, Google Scholar, and Scopus were searched
to find studies that reported radioprotective effects for arbutin. Besides, the data were searched
within the time period from 2010 to 2020.

Result:
Five research articles met our criteria, which were included in the analysis based on their
relevance to the topic. The present systematic review provides conclusions about various mechanisms
and pathways through which arbutin induces radioprotection.

Conclusions:
Based on the relevant studies, various mechanisms can be proposed for inducing
radioprotective effects by arbutin, including inhibition of oxidative stress, apoptosis, and inflammation.
Nutraceutical Potentials of Azanza garckeana (Snot Apple): A Review
Authors: Kazeem Mutiu Idowu , Adenowo Abiola Fatimah , Salisu Fausat Titilola , Akinsanya Mushafau Adewale 
Published: March 2022

Background:
Nutraceuticals are products derived from natural sources and are used as therapeutic agents for the management of various health disorders. Several nutraceuticals have been produced from fruits, including wild edible fruits. Azanza garckeana is an example of wild edible fruit belonging to the Malvaceae family. It is a semi-deciduous flowering plant that grows in savan-na-wooded grasslands and open forests. It can be found in tropical Eastern Africa, Southern Africa, and some countries of Western Africa. All parts of the plant are useful for medical and economic purposes. There are various traditional claims on the application of various parts of the plant in the management and treatment of diabetes, infertility, aches and pains, hemorrhage, liver and cardiac diseases, etc.

Objective:
This article presents a review of the plant Azanza garckeana regarding its botanical de-scription, its traditional relevance economically and medically, and its established nutritional as well as pharmacological relevance based on reported in vitro and in vivo experimental investigations.

Conclusion:
Experimental reports on the nutritional and pharmacological potentials of Azanza garckeana are sparse. Therefore, there is a need for extensive research to further establish the plant as a potential candidate for a pharmacological or nutraceutical agent for the management of oxida-tive stress-related diseases and other human health disorders.
Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany
Authors: Wilke Thomas , Weisser Burkhard , Predel Hans-Georg , Schmieder Roland E , Wassmann Sven , Gillessen Anton , Blettenberg Jörg , Maywald Ulf , Randerath Olaf , Müller Sabrina , Böhm Michael 
Published: March 2022

Aim:
This study assessed whether a single pill combination (SPC) is associated with lower direct healthcare costs.
Materials & methods:
Anonymized claims data of patients ≥18 years treated with drugs for cardiovascular (CV)-related diseases either as a single pill combination or multi-pill combination (follow-up to 1 year) were evaluated. After propensity score matching, 59,336 out of 1,369,840 patients were analyzed.
Results:
In all cohorts, patients receiving a single pill combination had a lower frequency of general practitioner and specialist visits. The patients also had a significantly lower ratio of all-cause hospitalization days and number of CV-related prescriptions as well as all-cause prescriptions (with one exception) compared with those receiving a multi-pill combination.
Conclusion:
Direct CV-related costs were significantly lower in four out of seven comparisons, with a trend toward lower costs in the other three comparisons.
STRUKTUR BETON BERTULANG PADA BALE DAJA
Authors: Luxiana I Wayan Suky , Parwata I Wayan , Kurniawan Agus 
Published: March 2022

Bale Daja merupakan bangunan berbetuk bujur sangkar dan memakai kontruksi atap limasan. Jumlah tiang pada bangunan Bale Daja berjumlah 12 buah empat tiang berderet di depan dan delapan tiang berada di dalam bangunan. Seiring perkembangan jaman dan teknologi Bale Daja bertransformasi dari Bale saka roras menjadi saka epat dimana didalamnya diganti dengan struktur beton bertulang. Struktur beton bertulang memberikan dampak signifikan baik dari kecepatan produksi, kecepatan kinerja, dan efisiensi biaya. Tujuan dari penelitian ini adalah dapat memberikan struktur beton bertulang yang diterapkan pada Bale Daja, baik secara dimensi, dan proses pembuatanya dan memberikan manfaat tanpa mengurangi nilai-nilai historis dari bale daja tersebut. Metode yang digunakan adalah metode kuantitatif dengan membuat model struktur, model kolom dan balok dimana sistematika perencanaan diuraikan dengan diagram alur. Hasil atau kesimpulan dimensi balok B= 1/12 x O, lebar balok R = ½ x B, besar kolom J = R + (2x I), lebar Pondasi S = ½ t
PEMBERDAYAAN MASYARAKAT DALAM PENCEGAHAN PENYAKIT GINJAL PASIEN DIABETES DAN HIPERTENSI DI RSUD SANJIWANI GIANYAR
Authors: Wardani Ni Wayan Sri 
Published: March 2022

Penyakit ginjal kronis (PGK) merupakan masalah kesehatan masyarakat global karena prevalensinya cendrung meningkat, prognosis yang buruk dan memerlukan biaya tinggi bila sudah memerlukan tindakan terapi pengganti ginjal. Peningkatan prevalensi PGK seiring dengan meningkatnya jumlah penyakit diabetes melitus dan hipertensi. Sekitar 1 dari 10 populasi global mengalami penyakit pada stadium tertentu. Data Indonesian Renal Registry tahun 2018 mendapatkan 132.000 pasien yang aktif menjalani dialisis dengan penyebab terbanyak adalah Diabetes Mellitus dan Hipertensi yaitu 64%. Perawatan penyakit ginjal memerlukan biaya yang tinggi. Di Indonesia, biaya perawatan penyakit ginjal menempati ranking kedua pembiayaan terbesar BPJS kesehatan setelah penyakit jantung. Dengan adanya peningkatan jumlah pasien Diabetes Melitus dan Hipertensi maka makin banyak pasien yang memerlukan tindakan dialisis, sehingga diperlukan upaya untuk melakukan pencegahan penyakit ginjal. Pencegahan penyakit ginjal dapat dilakukan dengan cara meningkatkan pengetahuan pasien Diabetes Mellitus dan hipertensi tentang pola hidup sehat dan deteksi dini penyakit ginjal dengan melakukan pemeriksaan urinalisis. Pencegahan dilakukan dengan melakukan tatap muka langsung dengan pasien dan diberikan penjelasan tentang bahaya penyakit ginjal dan cara pencegahannya, selanjutnya diberi leaflet untuk meningkatkan pemahaman pasien. Hasil kegiatan mendapatkan ada 60 orang pasien Diabetes dan Hipertensi yang berpartisipasi dalam program PKM ini dan didapatkan rerata peningkatan pengetauan pasien Diabetes dan Hipertensi tentang penyakit ginjal dan cara pencegahannya adalah 84.03 % dan terdeteksi adanya tanda penyakit ginjal kronik pada 50 persen pasien DM dan hipertensi yang berobat ke poliklinik Penyakit Dalam RSUD Sanjiwani Gianyar yang perlu di lakukan tindak lanjut dalam penanganan pasien tersebut.
Analisis Suara Pada Film Train To Busan Sutradara Yeon Sang-Ho
Authors: Manesah Dani , Damanik Andre Buttiamal 
Published: March 2022

Penelitian ini berjudul Analisis Suara Pada Film Train To Busan Sutradara Yeon Sang-Ho. Dimana suara mempunyai pint penting sehingga tidak dapat dihindarkan melalui proses pembuatan sebuah film. Sebagai sebuah fungsi dari unsur suara adalah sebagai isyarat yang mendeteksi bagaimana seharusnya secara emosional memikirkan sebuah tindakan ataupun sebuah peristiwa yang ada, yaitu melalui musik, fungsi suara dan juga dialog. Beberapa unsur tersebut merupakan sebuah unsur yang sangat penting dalam membangun mood hingga ketegangan pada setiap adegan pada film. Dalam penelitian ini peneliti menggunakan metode penelitian kualitatif, dan data yang diperoleh melalui film Train to Busan. Sementara objek dalam penelitian ini adalah suara yang terdapat dalam film Train to Busan. Tujuan dalam penelitian ini adalah untuk mengadakan pengawasan pada setiap unsur suara pada beberapa Gambar yang terdapat dalam film Train to Busan yang terbangun melalui unsur suara yang ditinjau melalui setiap elemen suara. Berdasarkan hasil analisa terhadap data yang diperoleh, yakni dapat disimpulkan bahwa unsur suara yang ditinjau melalui elemen suara pada film Train to Busan meliputi Digietic sound, Non Digietic Sound, On Screen, Off Screen dan Internal Getic Sound.
DESAIN PUZZLE UNTUK MELATIH KETERAMPILAN MOTORIK ANAK DOWN SYNDROME
Authors: Dwicadika Delima Atfon , Adiani Ningroom 
Published: March 2022

Jurnal ini berisikan tentang penelitian puzzle untuk melatih keterampilan motorik anak down syndrome. Anak Down Syndrome memiliki tingkat kecerdasan yang rendah dan memiliki masa pertumbuhan yang lambat dibandingkan dengan anak normal pada umumnya. Kebanyakan dari anak yang mengalami hambatan intelektual atau down syndrome mendapat kesulitan dalam melakukan gerak dasar yang memerlukan ketrampilan motorik kasar maupun motorik halus. Oleh karna itu di buat desain puzzle untuk melatih keterampilan motorik hakus maupun kasar pada anak down sindrom
Perancangan Iklan Layanan Masyarakat Stop Melawan Arus
Authors: Setiawati Titin , Sundari Lilis 
Published: March 2022

Didalam kegiatan keseharian lalu lintas memegang peran penting bagi masyarakat untuk memperlancar pembagunan yang kita laksanakan setiap harinya. Karena dengan adanya lalu lintas tersebut, memudahkan akses bagi masyarakat untuk melakukan kegiatan didalam pemenuhan perekonomiannya. Dibalik manfaat lalu lintas tersebut, terdapat juga berbagai permasalahan yang berkaitan dengan penggunaan jalan raya. Permasalahan yang muncul didalam perjalanan adalah kemacetan serta melawan arus. Melawan arus lalu lintas demi mencapai tujuan yang hanya lima meter di depan dibanding memutar lebih jauh namun sesuai dengan peraturan dan arus lalu lintas yang ada. Media cetak poster adalah strategi yang akan kita gunakan. Dengan pengaplikasian ditempel pada seluruh tempat yang bisa mencari perhatian mata sekuat mungkin, agar masyrakat sadar akan keselamatan didalam berkendara dan berhenti melawan arus.
The Model Disclosure of Islamic Social Reporting in Islamic Bank Indonesia
Authors: Siswanti Indra , Prowanta Embun 
Published: March 2022

Objectives: The purpose of this study is to analyze the determinants of the disclosure of Islamic Social Reporting in Islamic banks in IndonesiaMethodology: The population in this study are Islamic banks in Indonesia which amounted to 14 (fourteen) in total, while the sample used was 9 (nine) Islamic banks that have met the criteria, namely Islamic banks that have published financial reports, annual reports and corporate governance reports between the period of period 2015-2019.Finding: The results of this study indicate that compliance with sharia principles, duties and responsibilities of the sharia supervisory board have a significant positive effect on the disclosure of ISR whereas financial performance has no effect on the disclosure of ISR. Corporate governance has shown moderate effect of compliance sharia on the disclosure of ISR, while Corporate governance does not moderate effect of duties and responsibilities of sharia supervisory board on disclosure of ISR and Corporate governance moderate effect of financial performance on the disclosure of ISR.Conclusion: It is important for the Islamic banks in Indonesia to maintain compliance sharia principles, and to increase the role of sharia supervisory boards, financial performance and the implementation of corporate governance.
Buraquinhos por onde passar o movimento também na pandemia: entrevista sobre técnicas de dança e aulas online com Diana Gilardenghi
Authors: Gislon Giorgio Zimann 
Published: March 2022

Resumo: Nesta entrevista, Diana Gilardenghi discorre sobre as várias técnicas de dança que praticou durante seus anos de formação, conta o modo como atualmente combina essas técnicas nas suas aulas de dança contemporânea, narra suas experiências como professora de dança no ensino remoto durante a pandemia de Covid 19 e comenta o processo de criação do trabalho virtual ocupação mágica (2020).Palavras-chave: dança à distância; dança contemporânea; ensino remoto; técnicas de dança; performance virtual.
Teatralidade e Espetacularidade na Festa de Nazaré, em Belém do Pará
Authors: Almeida Ivone Maria Xavier de Amorim 
Published: March 2022

A Festa de Nazaré ou Círio de Nazaré – objeto de análise deste artigo - comporta em si vários eventos rituais que acontecem a partir do segundo domingo de outubro, na cidade de Belém, em louvação à Nossa Senhora de Nazaré, a padroeira dos paraenses. Neste texto o referencial teórico utilizado para a elaboração de reflexões sobre o fenômeno investigado é a Etnocenologia, em diálogo com a Sociologia do Drama Social. A construção da categoria conceitual corpo Cirieiro - como estados de corpo em processos de afetação pela relação íntima de fé daqueles que fazem, vivem e sentem a Festa em todas as suas dimensões - está assentada nas categorias Teatralidade e Espetacularidade. Todo o corpo textual deste artigo encontra amparo nas fontes consultadas e a leitura e interpretação dos fenômenos investigados estão subsidiadas nas ideias de BIÃO (2009), MAFFESOLI (1998), SANTA BRÍGIDA (2015), LÉVI-STRAUSS (1978), GOFFMAN (1989).