bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing ultramicroporous hard carbon spheres in carbonate ester‐based electrolytes for enhanced sodium storage in half‐/full‐cell sodium‐ion batteries
Authors: Nagmani  , Kumar Ananya , Puravankara Sreeraj 
Published: June 2022

AbstractSodium‐ion batteries (SIBs) have received considerable attention as promising next‐generation energy storage systems due to a large abundance of sodium and ion storage chemistry similar to that of lithium‐ion batteries (LIBs). We report ultramicroporous hard carbon microspheres (HCMSs) derived from sucrose via a microwave‐assisted solvothermal reaction as anode for SIBs. Because of the HCMSs with a larger interlayer spacing in graphitic domains and ultramicropores, it delivers excellent 3‐RC features (reversible capacity, rate capability, and retention of capacity) reported to date for hard carbons derived from sugar‐based carbon precursors through electrolyte optimization of carbonate esters (EC:PC, EC:DEC, EC:DMC). The HCMS‐PC delivered the best reversible capacity of 265 mAh g−1 at a current density of 300 mA g−1, showing 85.8% capacity retention after 100 cycles and 66.3% capacity retention after 500 cycles in a half‐cell. A full‐cell fabricated with an HCMS‐PC anode and a Na3V2(PO4)3 cathode delivered reversible capacities of 81 and 48 mAh g−1 at current densities of 30 and 300 mA g−1, respectively.
Carbon nanomaterials and their composites for supercapacitors
Authors: Zhong Mingzhu , Zhang Miao , Li Xifei 
Published: June 2022

AbstractAs a type of energy storage device between traditional capacitors and batteries, the supercapacitor has the advantages of energy saving and environmental protection, high power density, fast charging and discharging speed, long cycle life, and so forth. One of the key factors affecting the performance of supercapacitor is the electrode material. Carbon materials, such as carbon nanotube, graphene, activated carbon, and carbon nanocage, are most widely concerned in the application of supercapacitors. The synergistic effect of composites can often obtain excellent results, which is one of the common strategies to increase the electrochemical performance of supercapacitors. To further improve the performance of binary composites, it is a relatively simple method to increase the components as the “bridge” between the two materials to form the ternary composites. The review mainly introduces the current research progress of supercapacitors with pure carbon nanomaterials and multistage carbon nanostructures (composites) as electrodes. The characteristics and application directions of different pure carbon nanomaterials are introduced in detail. Different ways of multilevel structure (material) composite have their own effects on the development of high‐performance supercapacitors. We also highlight the recent advances related to these fields and provide our insight into high‐energy supercapacitors.
A Rapid, Highly Sensitive and Selective Phosgene Sensor Based on 5,6‐Pinenepyridine
Authors: Solea Atena B. , Curty Christophe , Fromm Katharina M. , Allemann Christophe , Mamula Steiner Olimpia 
Published: June 2022

AbstractThe toxicity of phosgene (COCl2) combined with its extensive use as a reactant and building block in the chemical industry make its fast and accurate detection a prerequisite. We have developed a carboxylic derivative of 5,6‐pinenepyridine which is able to act as colorimetric and fluorimetric sensor for phosgene in air and solution. For the first time, the formation of a pyrido‐[2,1‐a]isoindolone was used for this purpose. In solution, the sensing reaction is extremely fast (under 5 s), selective and highly sensitive, with a limit of detection (LOD) of 9.7 nM/0.8 ppb. When fixed on a solid support, the sensor is able to detect the presence of gaseous phosgene down to concentrations of 0.1 ppm, one of the lowest values reported to date.
A generation of synthesized trajectories of free moving objects for testing a set of continuous spatio‐temporal queries
Authors: Lee Sanghyun , Hong Bonghee , Kim Woochan 
Published: June 2022

SummaryTesting vessel surveillance monitoring queries requires synthesized trajectory generation data of free‐moving objects. This article presents a method for generating trajectories of free moving objects with approach, u‐turn, detour, and hover patterns to verify a set of continuous queries expressed in spatiotemporal conditions. We present an algorithm that generates simplified paths, moving patterns, and inertia‐based trajectories to make various types of trajectory patterns for a given spatiotemporal query. The experimental results show that the generated synthesized trajectory dataset can validate given spatiotemporal queries with different velocities, trajectory patterns, and travel paths.
Focusing on the long‐term recovery of severe acute respiratory syndrome coronavirus 2 infection: Clinically relevant observations
Authors: Wang Chunxia , Zhang Yucai 
Published: June 2022

BackgroundThe long‐term implications of COVID‐19 attract global attention in the post‐COVID‐19 pandemic era. Impaired lung function is the main sequelae in adults' survivors of SARS‐CoV‐2 infection.Methods and ResultsThe plasma proteomic pattern provides novel evidence on multiple biological domains relevant to
monitoring lung function and targeting the clinical application in adults with acute respiratory distress syndrome (ARDS) secondary to SARS‐CoV‐2 infection (SARS‐CoV‐2‐ARDS). Preliminary studies support the evidence of
pulmonary function tests (PFT) and computed tomography (CT) scan as routine follow‐up tools. Combining the early fibrotic indicators and D‐dimer levels could prove the validity and reliability of the proactive management of lung function assessment during the long‐term recovery in SARS‐CoV‐2 infection.ConclusionIn summary, protocolized PFT and CT scan and effective biomarkers for early fibrotic changes should be applied to clinical practice during the long follow‐up in patients with severe COVID‐19.
Direct targeted therapy for MLL‐fusion‐driven high‐risk acute leukaemias
Authors: Cantilena Sandra , Gasparoli Luca , Pal Deepali , Heidenreich Olaf , Klusmann Jan‐Henning , Martens Joost H. A. , Faille Alexandre , Warren Alan J. , Karsa Mawar , Pandher Ruby , Somers Klaartje , Williams Owen , de Boer Jasper 
Published: June 2022

AbstractBackgroundImproving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein‐driven paediatric cancer, with MLL (KMT2A)‐fusions present in most cases. Direct targeting of these driving oncoproteins represents a unique therapeutic opportunity. This rationale led us to initiate a drug screening with the aim of discovering drugs that can block MLL‐fusion oncoproteins.MethodsA screen for inhibition of MLL‐fusion proteins was developed that overcomes the traditional limitations of targeting transcription factors. This luciferase reporter‐based screen, together with a secondary western blot screen, was used to prioritize compounds. We characterized the lead compound, disulfiram (DSF), based on its efficient ablation of MLL‐fusion proteins. The consequences of drug‐induced MLL‐fusion inhibition were confirmed by cell proliferation, colony formation, apoptosis assays, RT‐qPCR, in vivo assays, RNA‐seq and ChIP‐qPCR and ChIP‐seq analysis. All statistical tests were two‐sided.ResultsDrug‐induced inhibition of MLL‐fusion proteins by DSF resulted in a specific block of colony formation in MLL‐rearranged cells in vitro, induced differentiation and impeded leukaemia progression in vivo. Mechanistically, DSF abrogates MLL‐fusion protein binding to DNA, resulting in epigenetic changes and down‐regulation of leukaemic programmes setup by the MLL‐fusion protein.ConclusionDSF can directly inhibit MLL‐fusion proteins and demonstrate antitumour activity both in vitro and in vivo, providing, to our knowledge, the first evidence for a therapy that directly targets the initiating oncogenic MLL‐fusion protein.
Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock
Authors: Scolari Fernando L. , Abelson Sagi , Brahmbhatt Darshan H. , Medeiros Jessie J.F. , Fan Chun‐Po S. , Fung Nicole L. , Mihajlovic Vesna , Anker Markus S. , Otsuki Madison , Lawler Patrick R. , Ross Heather J. , Luk Adriana C. , Anker Stefan , Dick John E. , Billia Filio 
Published: June 2022

AimsCardiogenic shock (CS) with variable systemic inflammation may be responsible for patient heterogeneity and the exceedingly high mortality rate. Cardiovascular events have been associated with clonal haematopoiesis (CH) where specific gene mutations in haematopoietic stem cells lead to clonal expansion and the development of inflammation. This study aims to assess the prevalence of CH and its association with survival in a population of CS patients in a quaternary centre.Methods and resultsWe compared the frequency of CH mutations among 341 CS patients and 345 ambulatory heart failure (HF) patients matched for age, sex, ejection fraction, and HF aetiology. The association of CH with survival and levels of circulating inflammatory cytokines was analysed. We detected 266 CH mutations in 149 of 686 (22%) patients. CS patients had a higher prevalence of CH‐related mutations than HF patients (odds ratio 1.5; 95% confidence interval [CI] 1.0–2.1, p = 0.02) and was associated with decreased survival (30 days: hazard ratio [HR] 2.7; 95% CI 1.3–5.7, p = 0.006; 90 days: HR 2.2; 95% CI 1.3–3.9, p = 0.003; and 3 years: HR 1.7; 95% CI 1.1–2.8, p = 0.01). TET2 or ASXL1 mutations were associated with lower survival in CS patients at all time‐points (p ≤ 0.03). CS patients with TET2 mutations had higher circulating levels of SCD40L, interferon‐γ, interleukin‐4, and tumour necrosis factor‐α (p ≤ 0.04), while those with ASXL1 mutations had decreased levels of CCL7 (p = 0.03).ConclusionsCardiogenic shock patients have high frequency of CH, notably mutations in TET2 and ASXL1. This was associated with reduced survival and dysregulation of circulating inflammatory cytokines in those CS patients with CH.
Prevalence and clinical outcomes of transthyretin amyloidosis: a systematic review and meta‐analysis
Authors: Antonopoulos Alexios S. , Panagiotopoulos Ioannis , Kouroutzoglou Alexandrina , Koutsis Georgios , Toskas Pantelis , Lazaros Georgios , Toutouzas Konstantinos , Tousoulis Dimitris , Tsioufis Konstantinos , Vlachopoulos Charalambos 
Published: June 2022

ABSTRACTAimSystematic evidence on the prevalence and clinical outcome of transthyretin amyloidosis (ATTR) is missing. We explored: (i) the prevalence of cardiac amyloidosis in various patient subgroups, (ii) survival estimates for ATTR subtypes, and (iii) the effects of novel therapeutics on the natural course of disease.Methods and resultsA systematic review of literature published in MEDLINE before 31 December 2021 was performed for the prevalence of cardiac amyloidosis and all‐cause mortality of ATTR patients. Extracted data included sample size, age, sex, and all‐cause mortality at 1, 2, and 5 years. Subgroup analyses were performed for ATTR subtype, that is, wild‐type ATTR (wtATTR) versus hereditary ATTR (hATTR), hATTR genotypes, and treatment subgroups. We identified a total of 62 studies (n = 277 882 individuals) reporting the prevalence of cardiac amyloidosis, which was high among patients with a hypertrophic cardiomyopathy phenotype, heart failure with preserved ejection fraction, and the elderly with aortic stenosis. Data on ATTR mortality were extracted from 95 studies (n = 18 238 ATTR patients). Patients with wtATTR were older (p = 7 × 10−10) and more frequently male (p = 5 × 10−20) versus hATTR. The 2‐year survival of ATTR was 73.3% (95% confidence interval [CI] 70.9–75.7); for non‐subtyped ATTR 70.4% (95% CI 66.9–73.9), for wtATTR 76.0% (95% CI 73.0–78.9]) and for hATTR 77.2% (95% CI 74.0–80.4); in meta‐regression analysis, wtATTR was associated with higher survival after adjusting for confounders. There was an interaction between survival and hATTR genotypes (p = 10−15, Val30Met having the lowest and Val122Ile/Thr60Ala the highest mortality). ATTR 2‐year survival was higher on tafamidis/patisiran compared to natural disease course (79.9%, 95% CI 74.4–85.3 vs. 72.4%, 95% CI 69.8–74.9, p < 0.05).ConclusionsWe report the prevalence of ATTR in various population subgroups and provide survival estimates for the natural course of disease and the effects of novel therapeutics. Important gaps in worldwide epidemiology research in ATTR were identified.
Dual Metallaphotoredox‐Catalyzed Directed C(sp2)−H Functionalization: Access to C−C/C‐Heteroatom Bonds
Authors: Sarkar Tanumay , Shah Tariq A. , Maharana Prabhat Kumar , Debnath Bijoy , Punniyamurthy Tharmalingam 
Published: June 2022

AbstractMetallaphotoredox catalysis represents the combination of two activation modes: metal‐catalyzed C−H functionalization and visible‐light‐induced photocatalysis. This appealing dual catalysis technique has evolved as a versatile platform that has paved the way for diverse low‐energy pathways for a plethora of synthetic transformations. The synergistic combination of two “green” approaches has garnered enormous interest owing to the development of sustainable strategies. In the recent past, significant advancements have been accomplished in constructing site‐selective C−C and C‐heteroatom bonds. This review outlines the use of photoredox catalysis in directing group‐assisted C−H functionalization reactions. The mechanistic insights of the developments and synthetic applications are addressed.
Nickel‐Catalyzed Tandem Ring Contraction of TEMPO and C−N Bond Transamination of Enaminones toward Amino Diversity of Enaminones
Authors: Wu Haozhi , Luo Tian , Wan Jie‐Ping , Jiang Jianwen , Liu Yunyun 
Published: June 2022

AbstractThe reactions of N,N‐substituted enaminones with TEMPO leading to the synthesis of 2,2‐dimethyl pyrrolidine functionalized new enaminones have been established by Ni(II) catalysis. The interesting ring contraction on TEMPO as well as the enaminone C−N bond amination bring new tool for generating molecular diversity of enaminones in the amino group fragment.
Multi‐family therapy for eating disorders across the lifespan: A systematic review and meta‐analysis
Authors: Zinser Jennifer , O’Donnell Nicola , Hale Lucy , Jones Christina J. 
Published: June 2022

AbstractEating disorders (EDs) have an estimated prevalence rate of 1%–5% across Europe. Effective adjunct interventions are needed to support the 20%–40% of families whose recovery requires additional support to first line approaches. This systematic review and meta‐analysis aimed to establish whether multi‐family therapy (MFT) improves the physical and psychological health of patients and family members. Searches were conducted in PsycINFO, MEDLINE, PubMed, EMBASE, CINAHL, and the Cochrane Library in March 2021. 15 studies (850 patients) met the inclusion criteria. Meta‐analysis demonstrated MFT resulted in significant benefits in weight gain, ED symptoms, patients' and parents' depression symptoms, and parents' negative experiences of caregiving. However, significant improvements were only evident when comparisons were drawn before and after the intervention; these dissipated when MFT was compared to another intervention. There was no evidence MFT improves family functioning, positive aspects of caregiving, nor patient and parental anxiety. Intervention completion rates ranged from 86% to 100% indicating a high level of acceptability. Studies varied with regard to intervention length and structure, follow‐up period, and outcome measures utilised; most were rated as moderate or weak in methodological quality. More rigorous and large scale randomised controlled trials are needed to fully assess the effectiveness of MFT.
Static creep rockburst mechanism and CT inversion verification of deep thick coal seam roadways
Authors: Zhang Ming , Hu Xuelong , Zhao Gaoming 
Published: June 2022

AbstractCompared with the traditional “dynamic‐static” load rockburst induced by working face mining, a new typical disaster with concealment characteristics has appeared in deep thick coal seam roadways, namely, static creep rockburst, the occurrence mechanism of which remains unclear. Through the method of combining theory with practice, this paper elucidated the mechanical mechanism of static creep rockburst of deep thick coal seam roadways, along with the CT inversion of its rockburst risk. Next, by establishing the creep model and three‐dimensional creep formula under static conditions, it was observed that the main conditions for the unstable creep of deep thick coal seam roadway were high stress and thick coal seam. In addition, by analyzing the unstable creep failure process of surrounding rock in static roadways, it was found that the weakening of surrounding rock strength and stress relief were the reasons for starting rockburst and reducing impedance. The mechanical conditions of creep rockburst caused by stress superposition in weak areas of the roadway under static conditions were proposed, and the criterion of rockburst possibility was given. Finally, according to the characteristics of spontaneity and time delay of such a rockburst disaster, the static creep rockburst evaluation of thick coal seam roadway before mining was achieved by CT inversion, and the research conclusions were thoroughly verified.
RETRACTED: Affirmative data analytics based data processing method for 6G wireless network applications
Authors: Jarrah Muath , Abu‐Khadrah Ahmed , Alrababah Hamza , Jaya Abdul Syukor Bin Mohamad , Alqattan Zakaria N. M. 
Published: June 2022

AbstractSixth generation (6G) wireless network infrastructure makes use of terahertz communication interfaces and latency service. The growth of real‐time applications and service support increases the data handling capacity and processing requirements. The data processing rate must be comparatively high with the available resources to meet the users' quality of service (QoS) requirements. This article proposes an affirmative data analytics (ADA) method to improve data processing consistency in 6G wireless networks. The consistency of the ADA method relies on the 6G service features in the service‐rendering environment. The affirmation process is provided using support vector machine (SVM) learning to achieve consistency in handling diverse‐attributed data. Then the attribute and association between data and services are achieved with best‐fit processing time and minimum complexity. The performance of the proposed ADA is verified for heterogeneous service applications in a wireless network using the metrics analysis time (723.629 ms), complexity (11.311%), and response time (1.034 s).
A Closer Look at the Environmental Impact of Solar and Wind Energy
Authors: Torres Jaime Fernández , Petrakopoulou Fontina 
Published: June 2022

AbstractMoving towards a sustainable society implies constant improvement in the way energy is supplied and consumed, with wider implementation of solar and wind energy facilities in stand‐alone or hybrid configurations. The goal of this work is to evaluate the lifecycle performance (construction and operation‐related impact) of large‐scale solar and wind energy systems and to compare it with conventional coal and natural gas fossil fuel plants under similar conditions. Environmental analyses of energy conversion systems today usually neglect the construction‐related environmental impact of fossil fuel plants, because it is significantly smaller than the impact related to the operation of the plant. However, the construction of large‐scale renewable plants implies the use of rare materials, transport‐related emissions, and other environmentally impactful activities. The plants evaluated here are configured and compared for similar emissions and similar power output. It is found that the life‐cycle environmental impact of the renewable plants could, in some specific cases, exceed that of the fossil fuel plants. Understanding the reasons behind this and the possible limitations of the different technologies can help plan for sustainable energy systems in the future. Finally, solutions to minimize the impact of renewable energy are proposed for more environmentally friendly implementation and future research.
Progress, Key Issues, and Future Prospects for Li‐Ion Battery Recycling
Authors: Wu Xiaoxue , Ma Jun , Wang Junxiong , Zhang Xuan , Zhou Guangmin , Liang Zheng 
Published: June 2022

AbstractThe overuse and exploitation of fossil fuels has triggered the energy crisis and caused tremendous issues for the society. Lithium‐ion batteries (LIBs), as one of the most important renewable energy storage technologies, have experienced booming progress, especially with the drastic growth of electric vehicles. To avoid massive mineral mining and the opening of new mines, battery recycling to extract valuable species from spent LIBs is essential for the development of renewable energy. Therefore, LIBs recycling needs to be widely promoted/applied and the advanced recycling technology with low energy consumption, low emission, and green reagents needs to be highlighted. In this review, the necessity for battery recycling is first discussed from several different aspects. Second, the various LIBs recycling technologies that are currently used, such as pyrometallurgical and hydrometallurgical methods, are summarized and evaluated. Then, based on the challenges of the above recycling methods, the authors look further forward to some of the cutting‐edge recycling technologies, such as direct repair and regeneration. In addition, the authors also discuss the prospects of selected recycling strategies for next‐generation LIBs such as solid‐state Li‐metal batteries. Finally, overall conclusions and future perspectives for the sustainability of energy storage devices are presented in the last chapter.
Presentation and outcomes of patients with clinically T1‐2, N0 parotid mucoepidermoid carcinoma: The roles of elective neck dissection and adjuvant radiotherapy
Authors: Al‐Qurayshi Zaid , Sullivan Christopher Blake , Allison Derek B. , Buchakjian Marisa R. 
Published: June 2022

AbstractObjectivesExamine the role of elective neck dissection (END) and adjuvant radiotherapy (RT) in early‐stage clinically N0 parotid mucoepidermoid carcinoma (MEC).MethodsThe study is a retrospective analysis of the National Cancer Database, 2004–2016. The study population included adult patients with MEC who underwent parotidectomy.ResultsA total of 1233 patients were included. Histopathology demonstrated well, moderately, and poorly differentiated MEC 47.12%, 39.98%, and 12.90% of the time, respectively. END was performed in 78.67% of patients, resulting in nodal upstaging in 4.43% and identification of extracapsular extension (ECE) in 0.72%. RT was utilized in 67.33% of patients with advanced pathological features. Neither END nor RT improved overall survival separately (p < 0.05) or combined (adjusted HR: 1.19, 95%CI: 0.52, 2.70, p = 0.68).ConclusionThis study provides an epidemiological perspective regarding patients with clinically T1‐2, N0 MEC. There was no observed survival advantage with END and RT.