bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dark matter indirect detection limits from complete annihilation patterns
Authors: Armand C. , Herrmann B. 
Published: November 2022

Abstract
While cosmological and astrophysical probes suggest that dark matter would make up for 85% of the total matter content of the Universe, the determination of its nature remains one of the greatest challenges of fundamental physics. Assuming the ΛCDM cosmological model, Weakly Interacting Massive Particles would annihilate into Standard Model particles, yielding γ-rays, which could be detected by ground-based telescopes. Dwarf spheroidal galaxies represent promising targets for such indirect searches as they are assumed to be highly dark matter dominated with the absence of astrophysical sources nearby. Previous studies have led to upper limits on the annihilation cross-section assuming single exclusive annihilation channels. In this work, we consider a more realistic situation and take into account the complete annihilation pattern within a given particle physics model. This allows us to study the impact on the derived upper limits on the dark matter annihilation cross-section from a full annihilation pattern compared to the case of a single annihilation channel. We use mock data for the Cherenkov Telescope Array simulating the observations of the promising dwarf spheroidal galaxy Sculptor. We show the impact of considering the full annihilation pattern within a simple framework where the Standard Model of particle physics is extended by a singlet scalar. Such a model shows new features in the shape of the predicted upper limit which reaches a value of 〈σv〉 = 3.8 × 10-24 cm-3s-1 for a dark matter mass of 1 TeV at 95% confidence level. We suggest considering the complete particle physics information in order to derive more realistic limits.
Segment Linking: A Highly Parallelizable Track Reconstruction Algorithm for HL-LHC
Authors: Chang P , Elmer P , Gu Y , Krutelyov V , Niendorf G , Reid M , Sathia Narayanan B V , Tadel M , Vourliotis E , Wang B , Wittich P , Yagil A 
Published: November 2022

Abstract
The High Luminosity upgrade of the Large Hadron Collider (HL-LHC) will produce particle collisions with up to 200 simultaneous proton-proton interactions. These unprecedented conditions will create a combinatorial complexity for charged-particle track reconstruction that demands a computational cost that is expected to surpass the projected computing budget using conventional CPUs. Motivated by this and taking into account the prevalence of heterogeneous computing in cutting-edge High Performance Computing centers, we propose an efficient, fast and highly parallelizable bottom-up approach to track reconstruction for the HL-LHC, along with an associated implementation on GPUs, in the context of the Phase 2 CMS outer tracker. Our algorithm, called Segment Linking (or Line Segment Tracking), takes advantage of localized track stub creation, combining individual stubs to progressively form higher level objects that are subject to kinematical and geometrical requirements compatible with genuine physics tracks. The local nature of the algorithm makes it ideal for parallelization under the Single Instruction, Multiple Data paradigm, as hundreds of objects can be built simultaneously. The computing and physics performance of the algorithm has been tested on an NVIDIA Tesla V100 GPU, already yielding efficiency and timing measurements that are on par with the latest, multi-CPU versions of existing CMS tracking algorithms.
Air shower radio signal electric field orientation as measured with the Astroneu Cosmic Ray telescope.
Authors: Nonis S , Leisos A , Tsirigotis A , Bourlis G , Papageorgiou K , Gkialas I , Manthos I , Tzamarias S 
Published: November 2022

Abstract
The Astroneu cosmic ray telescope is a small scale hybrid array consisting of both scintillator counters and electromagnetic radiation detectors in the radio-wave frequency (RF) band (antennas). Astroneu was installed and operated in the area of the Hellenic Open University (HOU) campus near the city of Patras in Greece. In the present development phase, the Astroneu telescope includes two stations consisting of 3 scintillation detectors modules (SDM) and one RF antenna while a third station includes 3 particle detectors and 4 RF antennas (3SDM-4RF). In this context we present the resent results from both the 3SDM-4RF autonomous station and simulations related to the estimation of the direction of the electric field emitted during the air shower development. The electric field measured in the ground level is the superposition of the two dominant emission mechanism, the time depended transverse current induced by the geomagnetic field and the net negative charge variation at the shower front. Since the electric field emitted by the two contributions is polarized in different directions the measured electric field in the ground encloses information about the charge-excess to geomagnetic ratio (CGR). Furthermore the orientation of the electric field emitted by charge-excess mechanism is strongly depends from the distance to the shower core (the intersection of the shower axis with the ground level). In this study we use the core information as reconstructed using the radio data and simulations. The estimated charge-excess to geomagnetic ratio is in agreement with previous studies which reveals that the shower core reconstruction method is efficient. Finally we report on that CGR measurements can be used for an efficient noise rejection in a future self trigger mode
The Detector Control System of the New Small Wheel Electronics for the ATLAS experiment
Authors: Tzanis Polyneikis 
Published: November 2022

Abstract
The present ATLAS Small Wheel Muon detector is be replaced with a New Small Wheel(NSW) detector in order to cope up with the future LHC runs of high luminosit. One crucial part of the integration procedure concerns the validation of the electronics for a system with more than 2.1 M electronic channels. The readout chain is based on optical link technology connecting the back-end to the front-end electronics via the FELIX, which is a newly developed system that serves as the next generation readout driver for ATLAS. For the configuration, calibration and monitoring path the various electronics boards are supplied with the GBT-SCA ASIC and its purpose is to distribute control and monitoring signals to the electronics. Due to its complexity, NSW electronics requires the development of a sophisticated Control System. The use of such a system is necessary to allow the electronics to function consistently, safely and as a seamless interface to all sub-detectors and the technical infrastructure of the experiment. The central system handles the transition between the probe’s possible operating states while ensuring continuous monitoring and archiving of the system’s operating parameters.
Formulating E- & T-Model Inflation in Supergravity
Authors: Pallis C 
Published: November 2022

Abstract
We present novel realizations of E- and T-model inflation within Supergravity which are largely associated with the existence of a pole of order one and two respectively in the kinetic term of the inflaton superfield. This pole arises due to the selected logarithmic Kahler potentials K, which parameterize hyperbolic manifolds with scalar curvature related to the coefficient (−N) < 0 of a logarithmic term. The associated superpotential W exhibits the same R charge with the inflaton-accompanying superfield and includes all the allowed terms. The role of the inflaton can be played by a gauge singlet or non-singlet superfield. Models with one logarithmic term in K for the inflaton, require N = 2, some tuning – of the order of 10−5 – between the terms of W and predict a tensor-to-scalar ratio r at the level of 0.001. The tuning can be totally eluded for more structured K’s, with N values increasing with r and spectral index close or even equal to its present central observational value.
Cooling ability of smooth and dimpled surfaces
Authors: Dobsakova L , Nguyen T D 
Published: November 2022

Reliable cooling of electronic components is an essential factor in electrical engineering. Every electronic device produces a certain amount of heat during its operation. This heat can cause overheating and a device can suffer damage. Therefore, the issue of cooling plays a significant role and is an important theme appropriate for continuously finding new improvements.
The paper describes a quantification of the heat transfer coefficients between a body and a surrounding environment. Experimental research of the heat transfer by cooling is focused on the plane smooth and structured surfaces. Surface structures improving the heat transfer rate are of dimples. The cooling process was measured by using a thermal imaging camera to obtain a cooling curve – the change in temperature time course during air cooling. The analysis of the cooling curve gradient allows us to identify convective and radiant components of the heat transfer. The presented results in the form of diagrams include different cases of air flow around smooth and dimpled surfaces.
Skull Walls
Authors: Heaney Christopher 
Published: November 2022

Abstract
From 1820 through 1920, American anthropologists acquired more human remains of Andean origin than those of any other individual population worldwide. Samuel George Morton, the Smithsonian, Harvard’s Peabody Museum of Archaeology and Ethnology, and the American Museum of Natural History all made “ancient Peruvians” core to their collections, racializing the Americas’ past and present by using “ancient Peruvians” as a historic set against which living Native Americans might be compared. This process fueled the collection of Indigenous remains in general and confirms Americanist historians’ need to attend to entanglement: US scholars were adapting a Peruvian tradition of knowledge and grave robbing in which the Andes possessed the Americas’ oldest, wealthiest, most “civilized,” and most plentiful human remains. It also reminds us that recent and useful conceptualizations of early American history as vast had disturbing early republican counterparts—in this case, a violent science that entangled precolonial, colonial, and republican North and South American temporalities and embodied them in the “historic” Indigenous dead. Reckoning with history’s role in colonization includes recognizing the literal, even spirited, remains of entanglement as historical forces in their own right, with temporalities beyond those of the United States.
Bolster Equalization Suture Technique (BEST) Neck: Optimization of Skin Redraping Following Necklift Surgery
Authors: Mentz Henry , Rodriguez Abigail , Garlick Jared , Mentz James , Ogley Scott , Kumbla Pallavi A 
Published: November 2022

AbstractBackgroundSkin laxity of the neck is a primary concern of patients seeking facial rejuvenation. Traditional methods for redraping neck skin have well-described shortcomings.ObjectivesThe aim of this study was to optimize skin redraping after necklift surgery while reducing risk, and the Bolster Equalization Suture Technique (BEST).MethodsAt the conclusion of the facelift and necklift, 3 external quilting sutures are placed with protective bolsters. The first suture is placed at the midline, advancing the skin posteriorly toward the hyoid and anchoring the skin to the platysma. The second and third are placed in the cervicomandibular groove over the sternocleidomastoid muscle, advancing the skin posteriorly. Complications such as skin necrosis, skin ischemia, dimpling, hypopigmentation, hyperpigmentation, and scarring were documented. A control group of 20 patients who underwent the same surgery without the BEST was compared to the next 20 patients in which the BEST was applied. Preoperative and postoperative photographs were blindly reviewed by 2 plastic surgeons. The photographs were analyzed for residual central neck skin laxity and cervicomental angle improvement and surveyed according to the pertinent sections of the FACE-Q.ResultsIn necklift patients who received the BEST, cervicomental angle improvement and decreased central skin laxity were statistically significant. Patient perceived age on a visual analog scale was 2.5 years younger in the BEST group.ConclusionsThe BEST is a safe and efficient method which can be used to improve cervical skin redraping and contour. The BEST creates a more defined cervicomental angle while reducing central skin neck laxity with minimal complications.Level of Evidence: 4
BIA-ALCL Epidemiological Findings From a Retrospective Study of 248 Cases Extracted From Relevant Case Reports and Series: A Systematic Review
Authors: Santanelli Di Pompeo Fabio , Panagiotakos Demosthenes , Firmani Guido , Sorotos Michail 
Published: November 2022

Abstract

Background
The epidemiologic picture of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) is unclear, with no high-level evidence, because only case reports and series are available.

Objectives
The aim of this study was to update knowledge on BIA-ALCL epidemiology by utilizing all available data through a systematic review of scientific literature.

Methods
A search on PubMed, Scopus, and Web of Science was conducted between October 2021 and April 2022. Out of the 2799 available records, 114 pertinent articles were selected, featuring 248 BIA-ALCL cases which were retrospectively analyzed by means of descriptive statistics, incidence rate (IR), Kaplan-Meier survival curves, and Pearson correlation coefficients.

Results
The United States, the Netherlands, Italy, and Australia were the countries reporting the most cases. The mean age at first implantation was 42 years, and the mean age at diagnosis was 53 years. Aesthetic indications were the reason for 52% of cases, and reconstruction for 48%; macrotextured surface was linked to 73.8% of cases, and seroma to 83%. Total follow-up was 492 months, and mean event-free time (EFT) to BIA-ALCL development was 129 months. The IR was 96 new cases/1,000 women per year after first implantation, and was directly correlated to the number of replacements. EFT was directly correlated to the number of replacements, implant rupture, and capsule contracture, and was inversely associated with patients' age at first implantation and to BRACA1/2 and TP53 mutations.

Conclusions
Macrotextured implant use in older patients and in patients with BRCA1/2 and TP53 mutations should be reconsidered, because this is associated with earlier disease onset. Implant replacement of asymptomatic, risk-stratified patients can be indicated due to its protective role against BIA-ALCL, reducing IR and risk, while increasing the EFT.
Synthesis and structure-activity relationship study of aldose reductase inhibiting marine alkaloid lukianol A and its derivatives
Authors: Ishibashi Fumito , Zha Shijiao , Kondo Taiyo , Sakamoto Mayu , Ueno Mikinori , Fukuda Tsutomu 
Published: November 2022

ABSTRACT
Lukianol A (1a) and its six derivatives 1b-1g, in which each hydroxyl groups of 1a was individually modified, were synthesized via the common intermediate 7a, which was obtained by condensation of the styryl carbazate 10 with p-hydroxyphenylpyruvic acid and subsequent [3,3]-sigmatropic rearrangement. The synthesized lukianol derivatives were evaluated for their ability to inhibit human aldose reductase. 4′-O-methyl (1b) and 4′-dehydroxy (1g) derivatives showed the same level of inhibitory activity as 1a (IC50 2.2 µm), indicating that the 4′-OH is irrelevant for the activity. In contrast, methylation of the hydroxyl group at the 4″′-position (1d) resulted in the loss of activity at a concentration of 10 µm, and masking the hydroxyl group at the 4″-position (1e) caused a 9-fold decrease in activity compared with that of 1b, suggesting that the 4″-OH is an essential group, and the 4″′-OH is required for higher activity.
Multi-view spectral clustering with latent representation learning for applications on multi-omics cancer subtyping
Authors: Ge Shuguang , Liu Jian , Cheng Yuhu , Meng Xiaojing , Wang Xuesong 
Published: November 2022

AbstractDriven by multi-omics data, some multi-view clustering algorithms have been successfully applied to cancer subtypes prediction, aiming to identify subtypes with biometric differences in the same cancer, thereby improving the clinical prognosis of patients and designing personalized treatment plan. Due to the fact that the number of patients in omics data is much smaller than the number of genes, multi-view spectral clustering based on similarity learning has been widely developed. However, these algorithms still suffer some problems, such as over-reliance on the quality of pre-defined similarity matrices for clustering results, inability to reasonably handle noise and redundant information in high-dimensional omics data, ignoring complementary information between omics data, etc. This paper proposes multi-view spectral clustering with latent representation learning (MSCLRL) method to alleviate the above problems. First, MSCLRL generates a corresponding low-dimensional latent representation for each omics data, which can effectively retain the unique information of each omics and improve the robustness and accuracy of the similarity matrix. Second, the obtained latent representations are assigned appropriate weights by MSCLRL, and global similarity learning is performed to generate an integrated similarity matrix. Third, the integrated similarity matrix is used to feed back and update the low-dimensional representation of each omics. Finally, the final integrated similarity matrix is used for clustering. In 10 benchmark multi-omics datasets and 2 separate cancer case studies, the experiments confirmed that the proposed method obtained statistically and biologically meaningful cancer subtypes.
SWI/SNF chromatin remodeling subunitSmarca4/BRG1 is essential for female fertility
Authors: Abedini Atefeh , Landry David A , Macaulay Angus D , Vaishnav Het , Parbhakar Ashna , Ibrahim Dalia , Salehi Reza , Maranda Vincent , Macdonald Elizabeth , Vanderhyden Barbara C 
Published: November 2022

AbstractMammalian folliculogenesis is a complex process that involves the regulation of chromatin structure for gene expression and oocyte meiotic resumption. The SWI/SNF complex is a chromatin remodeler using either Brahma-regulated gene 1 (BRG1) or BRM (encoded by Smarca4 and Smarca2, respectively) as its catalytic subunit. SMARCA4 loss of expression is associated with a rare type of ovarian cancer; however, its function during folliculogenesis remains poorly understood. In this study, we describe the phenotype of BRG1 mutant mice to better understand its role in female fertility. Although no tumor emerged from BRG1 mutant mice, conditional depletion of Brg1 in the granulosa cells (GCs) of Brg1fl/fl;Amhr2-Cre mice caused sterility, whereas conditional depletion of Brg1 in the oocytes of Brg1fl/fl;Gdf9-Cre mice resulted in subfertility. Recovery of cumulus-oocyte complexes after natural mating or superovulation showed no significant difference in the Brg1fl/fl;Amhr2-Cre mutant mice and significantly fewer oocytes in the Brg1fl/fl;Gdf9-Cre mutant mice compared with controls, which may account for the subfertility. Interestingly, the evaluation of oocyte developmental competence by in vitro culture of retrieved two-cell embryos indicated that oocytes originating from the Brg1fl/fl;Amhr2-Cre mice did not reach the blastocyst stage and had higher rates of mitotic defects, including micronuclei. Together, these results indicate that BRG1 plays an important role in female fertility by regulating granulosa and oocyte functions during follicle growth and is needed for the acquisition of oocyte developmental competence.
Early onset hereditary neuronopathies: an update on non-5qmotor neuron diseases
Authors: Zambon Alberto A , Pini Veronica , Bosco Luca , Falzone Yuri M , Munot Pinki , Muntoni Francesco , Previtali Stefano C 
Published: November 2022

AbstractHereditary motor neuropathies (HMN) were first defined as a group of neuromuscular disorders characterized by lower motor neuron dysfunction, slowly progressive length-dependent distal muscle weakness and atrophy, without sensory involvement. Their cumulative estimated prevalence is 2.14/100 000 and, to date, around 30 causative genes have been identified with autosomal dominant, recessive,and X-linked inheritance. Despite the advances of next generation sequencing, more than 60% of patients with HMN remain genetically uncharacterized. Of note, we are increasingly aware of the broad range of phenotypes caused by pathogenic variants in the same gene and of the considerable clinical and genetic overlap between HMN and other conditions, such as Charcot-Marie-Tooth type 2 (axonal), spinal muscular atrophy with lower extremities predominance, neurogenic arthrogryposis multiplex congenita and juvenile amyotrophic lateral sclerosis.Considering that most HMN present during childhood, in this review we primarily aim to summarize key clinical features of paediatric forms, including recent data on novel phenotypes, to help guide differential diagnosis and genetic testing. Second, we describe newly identified causative genes and molecular mechanisms, and discuss how the discovery of these is changing the paradigm through which we approach this group of conditions.