bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers
Authors: Chen Zhikang , Lai Xiaobo , Ding Hui , Zhang Aijun , Sun Yufei , Ling Jianhua , Chiao Paul J. , Chen Zihua , Xia Xuefeng 
Published: June 2022

AbstractBackgroundLimited by difficulties in early detection and availabilities of effective treatments, pancreatic cancer is a highly malignant disease with poor prognosis. Nuclear receptors are a family of ligand‐dependent transcription factors that are highly druggable therapeutic targets playing critical roles in human physiological and pathological development, including cancer. In this study, we explored the therapeutic potential as well as the molecular mechanisms of liver X receptor (LXR) agonist GW3965 in pancreatic cancer.MethodsSoft‐agar colony formation assay, xenograft tumors, Oligonucleotide microarray, Reverse transcription real‐time polymerase chain reaction, Western immunoblotting and Immunohistochemistry were used in this study.ResultsWe demonstrated pleotropic in vitro activities of GW3965 in pancreatic cell lines MIA PaCa‐2 and BXPC3 including reduction of cell viability, inhibition of cell proliferation, stimulation of cell death, and suppression of colony formation, which translated to significant inhibition of xenograft tumor growth in vitro. By mapping the gene expression profiles, we identified the up‐regulations of 188 and the down‐regulations of 92 genes common to both cell lines following GW3965 treatment. Genes responsive to GW3965 represent a variety of biological pathways vital for multiple cellular functions. Specifically, we identified that the activating transcription factor 4/thioredoxin‐interacting protein/regulated in development and DNA damage responses 1/mechanistic target of rapamycin (ATF4/TXNIP/REDD1/mTOR) signaling critically controls GW3965‐mediated regulation of cell proliferation/death. The significance of the ATF4/TXNIP/REDD1/mTOR pathway was further supported by associated expressions in xenograft tumors as well as human pancreatic cancer samples.ConclusionsThis study provides the pre‐clinical evidence that LXR agonist is a promising therapy for pancreatic cancer.
Exploring cisgender therapists' attitudes towards, and experience of, working with trans people in the United Kingdom
Authors: Mollitt Paul Christopher 
Published: June 2022

AbstractObjectivesResearch suggests therapists may be lacking the skills and experience to work with the trans population and may hold a range of personal and professional views about trans people, in line with wider society. The aim of this study is to understand attitudes that qualified cisgender UK therapists have towards this client group, how equipped they feel to work with them and to identify gaps in training and experience.DesignA mixed‐methods, concurrent nested design was used.MethodsData were generated via an online survey. Quantitative data were analysed alongside a reflexive thematic analysis.ResultsThe politicisation of trans identities has created a toxic debate that has left therapists confused about their professional and personal stance, but there is an earnest attempt to understand this. Therapists are generally supportive of trans people and a majority have worked with this community, but a significant minority of these therapists could be said to hold transphobic views or working practices. Therapists feel ill‐equipped to work with the trans community and are fearful of getting things wrong. Younger, more recently trained therapists are more comfortable working with gender identity, with older, “gender critical” and psychoanalytic therapists struggling the most.ConclusionsThe politicisation of trans identities has created a split in UK therapists, and work is necessary to ensure adequate training and ongoing reflexivity regarding personal biases. Clarity and reassurance are needed on the implications of the proposed conversion therapy ban, particularly on exploratory therapeutic work within an affirmative stance.
Chemical Composition and Androgenic Effect of Bee Drone Larvae (Apilarnil) for Goat Male Kids
Authors: Koşum Nedim , Yücel Banu , Kandemir Çağrı , Taşkın Turgay , Duru Mehmet Emin , Küçükaydın Selçuk , Margaoan Rodica , Cornea‐Cipcigan Mihaiela 
Published: June 2022

AbstractPresent study aimed to establish the stimulatory effects of bee drone larvae (BDL) on the androgenic effects and growth performance of goat male kids (GMK). The effects of BDL on growth and testosterone hormone levels were investigated in Saanen male kids. A total of 26 Saanen male kids (13 heads control, 13 heads treatment groups) were used for determining the effects of BDL 60 days after the weaning period. BDL was obtained from “good beekeeping practices” hives. Hormone levels, growth trials, testes characteristics, and body measurements were determined every 14 days on the days 75, 90, 105, 120, and 135 of the trial. The increasing level of testosterone hormone in the treatment group on 135 days strengthened the hypothesis that the BDL could have greater effects in the case of more application that is expensive and considering the time of maturity of Saanen GMK. The lipid composition of BDL was identified by GC/MS. Oleic acid (64.75 %) and palmitic acid (26.08 %) were the dominant lipid compounds of BDL. Additionally, the phenolic/organic acid profile investigated by HPLC‐DAD revealed that trans‐aconitic acid (11.20±0.32 μg/g) and fumaric acid (5.03±0.41 μg/g) were found as major compounds in BDL.
Power and potential: Engaging adjunct faculty as leaders and agents of change
Authors: Layou Karen M. , Goering Andrea E. , James Bridget R. , Morales Marla , Nagy Robin , Rosas Alquicira Edgar Francisco , Macdonald R. Heather 
Published: June 2022

AbstractThis chapter presents the experiences of adjunct faculty in the SAGE 2YC: Faculty as Change Agents project through the stories of five participants who share the influence of the project on them and their work. We describe the professional development that occurred in the project, which included learning with colleagues from across the country, implementing changes in their classroom teaching and beyond, and leading follow‐on workshops in teams on campus and/or in the region. The participant stories illustrate how the project gave them agency and validated their work. Adjunct faculty make important contributions to student and faculty success, and there is power in engaging adjunct faculty as leaders and change agents and fully realizing their potential.
Effects of Protein Content on Pickering‐assisted Interfacial Enzyme Catalysis
Authors: Plikat Christoph , Drews Anja , Ansorge‐Schumacher Marion B. 
Published: June 2022

AbstractIn recent years, water‐in‐oil Pickering emulsions have been introduced as promising reaction systems for multiphase enzyme catalysis, in particular lipase‐catalyzed esterification and transesterification. Here, we for the first time gained insight into the effects that the presence of the proteins exert on the fineness and stability of the emulsion system and thus, the catalytic performance. We demonstrated a distinct, concentration‐ and enzyme‐dependent decrease of droplet sizes in the dispersed phase, accompanied by decreasing stability against coalescence. This was due to a probably quantitative adsorption of lipases at the interphase intercalating the solid particles. Destabilization was reduced slightly at increased particle content and increased volume portion of the dispersed phase, respectively. However, the low tolerable lipase concentrations in the reaction system considerably limited its productivity. Thus, our study points at the enzyme content, or rather enzyme location, in Pickering emulsions being the crucial parameter for optimizing catalytic performance.
The Italian COVID‐19 Anxiety Syndrome Scale: Investigation of the COVID‐19 anxiety syndrome and its association with psychological symptoms in an Italian population
Authors: Mansueto Giovanni , Palmieri Sara , Marino Claudia , Caselli Gabriele , Sassaroli Sandra , Ruggiero Giovanni Maria , Nikčević Ana V. , Spada Marcantonio M. 
Published: June 2022

AbstractIntroductionThe COVID‐19 Anxiety Syndrome Scale (C‐19ASS) is a quick and reliable scale assessing dysfunctional coping strategies activated in response to COVID‐19 fear and threat. The present study aimed to provide a preliminary validation of the Italian version of the C‐19ASS and investigated whether the C‐19ASS would mediate the relationship between the Big Five personality traits and psychological outcomes.MethodIn Study 1, a community sample of 271 participants completed the Italian version of the C‐19ASS and results were subjected to a Principal Component Analysis. In study 2, a community sample of 484 participants completed the Italian version of the C‐19ASS and a series of measures assessing COVID‐19 anxiety, COVID‐19 fear, functional impairment, personality traits, depression, generalized anxiety and health anxiety. Internal consistency, concurrent and incremental validity were assessed. Path analyses were run.ResultsFactor analysis identified a two‐factor solution (i.e., C‐19ASS Perseveration and C‐19ASS Avoidance) and confirmatory factor analysis suggested a two‐factor model best fits the data. The Italian version of the C‐19ASS showed good internal consistency. There was also evidence of convergent validity and incremental validity. Path analyses showed that C‐19ASS Perseveration mediates the relationship between emotional stability and psychological symptoms (depression, generalized anxiety and health anxiety).ConclusionThe Italian version of the C‐19ASS appears to be a reliable and valid measure of the COVID‐19 anxiety syndrome. The COVID‐19 anxiety syndrome could be a suitable therapeutic target to reduce psychological symptoms typically linked to pandemic events, such as depression generalized anxiety and health anxiety.
Edge‐to‐edge percutaneous mitral repair for functional ischaemic and non‐ischaemic mitral regurgitation: a systematic review and meta‐analysis
Authors: Chiarito Mauro , Sanz‐Sanchez Jorge , Pighi Michele , Cannata Francesco , Rubbio Antonio Popolo , Munafò Andrea , Cao Davide , Roccasalva Fausto , Pini Daniela , Pagnotta Paolo A. , Ettori Federica , Petronio Anna Sonia , Tamburino Corrado , Reimers Bernhard , Colombo Antonio , Di Mario Carlo , Grasso Carmelo , Mehran Roxana , Godino Cosmo , Stefanini Giulio G. 
Published: June 2022

AbstractAimRandomized controlled trials comparing the use of the MitraClip device in addition to guideline directed medical therapy (GDMT) to GDMT alone in patients with secondary mitral regurgitation (MR) have shown conflicting results. However, if these differences could be due to the underlying MR aetiology is still unknown. Therefore, we aimed to evaluate if the effects of percutaneous edge‐to‐edge repair with MitraClip implantation could differ in patients with ischaemic (I‐MR) and non‐ischaemic mitral regurgitation (NI‐MR).Methods and resultsPubMed, Embase, BioMed Central, and the Cochrane Central Register of Controlled Trials were searched for all studies including patients with secondary MR treated with the MitraClip device. Data were pooled using a random‐effects model. Primary endpoint was the composite of all‐cause death and heart failure‐related hospitalization. Secondary endpoints were the single components of the primary endpoint, New York Heart Association functional Classes III and IV, and mitral valve re‐intervention. Seven studies enrolling 2501 patients were included. Patients with I‐MR compared with patients with NI‐MR had a similar risk of the primary endpoint (odds ratio: 1.17; 95% confidence interval: 0.93 to 1.46; I2: 0%). The risk of all‐cause death was increased in patients with I‐MR (odds ratio: 1.31; 95% confidence interval: 1.07 to 1.62; I2: 0%), while no differences were observed between the two groups in terms of the other secondary endpoints.ConclusionsThe risk of mortality after MitraClip implantation is lower in patients with NI‐MR than in those with I‐MR. No absolute differences in the risk of heart failure related hospitalization were observed between groups.
Synemin promotes pulmonary artery smooth muscle cell phenotypic switch in shunt‐induced pulmonary arterial hypertension
Authors: Zhou Jingjing 
Published: June 2022

AbstractAimsAlthough considerable progress has been made in the diagnosis and treatment of congenital heart disease‐associated pulmonary heart hypertension (CHD‐PAH), the clinical prognosis and overall survival of patients with CHD‐PAH remain poor. Therefore, the molecular pathogenesis of CHD‐PAH requires further investigation. The intermediate filament protein synemin (SYN) is reported to modulate phenotypic alterations and varicose vein development, but there is little understanding of its exact functions in CHD‐PAH.Methods and resultsSYN expression in the pulmonary arterioles of CHD‐PAH patients and shunt‐induced PAH rat models was evaluated using immunohistochemistry and western blot. Cell counts and Transwell migration assays were used to assess the effect of SYN on the proliferation and migration capability of human pulmonary smooth muscle cells (hPASMCs). Adeno‐associated viruses (AAVs) have been used to suppress SYN expression in the pulmonary arterioles of rats. Such rats were further used to construct a shunt‐induced PAH animal model to investigate the function of SYN in PAH and pulmonary vascular remodelling. Compared with the normal control group, SYN expression was found to be clearly up‐regulated in the remodelled pulmonary arterioles of CHD‐PAH and shunt‐induced PAH rat models. In addition, SYN suppression increased the expression of hPASMC contractile‐phenotype markers and decreased the expression of synthetic phenotype markers, in contrast to the control group. SYN suppression also dramatically attenuated the proliferation and migration capability of hPASMCs. Conversely, SYN overexpression promoted phenotypic switch, proliferation, and migration of hPASMCs, whereas these effects were notably alleviated by the protein kinase B (AKT) inhibitor MK‐2206. Furthermore, we confirmed that SYN suppression mitigated PAH and pulmonary vascular remodelling induced by high blood flow in vivo.ConclusionsOur findings indicated that SYN may represent a promising therapeutic target in the treatment of CHD‐PAH.
Conceptualizing the multispecies triad: Toward a multispecies intersectionality
Authors: Petitt Andrea 
Published: June 2022

AbstractFeminist and multispecies anthropologies have decentered those most visible to appreciate the perspectives of those othered in society—but also to better understand society at large. This article goes beyond decentering the human toward decentering another analytical focus: the species dyad. Building on previous work on gender–species intersectionality and multispecies ethnography, as well as drawing on a set of five ethnographic and multispecies fieldwork studies involving gendered relations between humans, cattle, and horses on three continents, this article offers a conceptualization of the multispecies triad by outlining a multispecies intersectionality theory. This entails acknowledging the intersectionality of five sets of relations: (1) species as a power relation beyond biology; (2) intersecting power relations of humans (such as gender and ethnicity as well as local categories); (3) humans’ organization of nonhumans into intraspecies categories (by for example sex, breed, age as well as local categories); (4) nonhumans’ own intraspecies power relations; and (5) nonhumans’ relations to intraspecies groups of other species (including human subgroups). By situating a multispecies triad in this multispecies intersectionality, the article shows how relations of power intersect within and across species with consequences for individuals and groups of all species involved. Multispecies intersectionality can thus be of interest even to scholars primarily interested in humans.
Locking out prevention: Dental care in the midst of a pandemic
Authors: Danagoulian Shooshan , Wilk Thomas A. 
Published: June 2022

AbstractEmergencies, such as natural and manmade disasters, can present an opportunity or be a detriment to preventive healthcare. While stay‐at‐home orders which some states implemented to mitigate the impact of COVID‐19 are known to reduce acute and routine care, little is known about missed preventive care. Dental care, unlike other forms of preventive care ‐ such as pediatric vaccines and well‐visits, is simpler to analyze as it is not practicable with telehealth. Using weekly foot traffic data by SafeGraph from January 2018 to June 2020, we examine the effect of stay‐at‐home orders on visits to dental offices, finding a 15.4% decline after March 2020 for states with stay‐at‐home orders. Surprisingly, we find that states which allowed dental care during the stay‐at‐home period experienced a further 7.4% decline in visits. Using Michigan Medicaid dental claims for children we find that the decline of 0.25 claims per month is driven primarily by fewer diagnostic and preventive care visits. Though some preventive visits were rescheduled, we estimate only 58% of visits missed in March and April 2020 were made up by the end of the year. These estimates quantify the short‐term declines in preventive dental care, suggesting similar declines in other preventive care.
How do HRD professionals and business managers interact in organizing HRD activities?
Authors: Lundgren Henriette , Poell Rob F. 
Published: June 2022

AbstractHuman resource development (HRD) has traditionally been seen as the main driver behind people‐centered developmental activities such as learning and development, organization development, and career development. However, the role of HRD professionals as the main stakeholder has been questioned as more and more people‐centered development activities have been integrated into a broad range of leadership and supervisory roles within the organization. The question arises: How do HRD professionals and business managers interact in organizing HRD activities? Building on structure and actor theories as a theoretical foundation, the study combines deductive and inductive data analysis of semi‐structured interviews to review the roles of HRD professionals and business managers involved in organizing HRD activities in six different organizations in the USA. Our findings show that while training does not appear in any of the HR‐related job titles, the term “training” is more common in business managers' titles describing their link to HRD activities. When organizing those activities, HRD professionals and business managers engage extensively in emergent partnering structures. While some HRD professionals are the main actors in some learning networks, business managers drive HRD activities in others. We discuss the commingling of actors and its impact on the learning network. The paper closes with a discussion of research limitations, future research, and implications for HRD practice.
Detection of liver abnormalities—A new paradigm in medical image processing and classification techniques
Authors: R Karthikamani , Rajaguru Harikumar 
Published: June 2022

AbstractThe liver is the body's most essential organ, and all human activities are interrelated with normal liver function. Any malfunction of the liver may lead to fatal diseases; therefore, early detection of liver abnormalities is essential. Modern medical imaging techniques combined with engineering procedures are reducing human suffering caused by liver disease. This study uses multiple classifiers to detect liver cirrhosis in ultrasonic images. The ultrasound images were obtained from The Cancer Imaging Archive database. A gray‐level co‐occurrence matrix (GLCM) and statistical approaches are used to extract features from normal and liver‐cirrhosis images. The extracted GLCM features are normalized and classified using nonlinear regression, linear regression, logistic regression, Bayesian Linear Discriminant Classifiers (BLDC), Gaussian Mixture Model (GMM), Firefly, Cuckoo search, Particle Swarm Optimization (PSO), Elephant search, Dragon Fly, Firefly GMM, Cuckoo search GMM, PSO GMM, Elephant search GMM, and Dragon Fly GMM classifiers. Benchmark metrics, such as sensitivity, specificity, accuracy, precision, negative predictive value, false‐negative rate, balanced accuracy, F1 score, Mathew correlation coefficient, F measure, error rate, Jaccard metric, and classifier success index, are assessed to identify the best‐performing classifier. The GMM classifier outperformed other classifiers for statistical features, and it achieved the highest accuracy (98.39%) and lowest error rate (1.61%). Moreover, the Dragon Fly GMM classifier achieved 90.69% for the GLCM feature used to classify liver cirrhosis.
Assessing extreme precipitation from a regional climate model in different spatial–temporal scales: A hydrological perspective in South America
Authors: Brêda João Paulo Lyra Fialho , de Paiva Rodrigo Cauduro Dias , Chou Sin Chan , Collischonn Walter 
Published: June 2022

AbstractGlobal and regional climate models (GCM and RCM respectively) are the current mathematical tools used to project alterations on precipitation regimes given different greenhouse gases emissions scenarios. However, these models have specific resolutions, physical equations and numerical approaches that provide a diverse set of performances across different regions and spatial–temporal scales. In South America, most hydrological impact studies have used the Eta RCM to yield precipitation projections without a proper uncertainty analysis. It is important to acknowledge its uncertainties prior to any hydrological assessment to adequately support climate change investigations and related water decision making. Therefore, we aim to investigate how Eta extreme precipitation biases vary in different spatial–temporal scales from a hydrological perspective. Thus, we evaluate the extreme precipitation generated by the Eta RCM driven by four different GCMs. It is investigated Eta biases across different temporal (3 hr–5 days) and spatial scales (0.2–1.0°) and how those errors affect river streamflow simulations. It is used local intensity–duration–frequency (IDF) curves and gridded precipitation datasets (MSWEP and ERA5‐Land) as references for Eta assessment. In general, Eta underestimates subdaily extreme precipitation across South America, regardless of the driven GCM. The median bias of a 10‐year return period daily precipitation is −36 mm (1st and 3rd quantiles −58 and −17 mm) compared to MSWEP and −26 mm (1st and 3rd quantiles −45 and −11 mm) compared to ERA5‐Land. However, the relative errors reduce with temporal and spatial aggregation. For example, the average bias of extreme precipitation decreases 8.4 and 5.4 percentage points from 1‐ to 5‐day duration compared to MSWEP and ERA5‐Land, respectively. The negative biases observed for precipitation (20%) are propagated to the flood discharges (40%), and these errors reduce with the drainage area. In general, there are greater biases in extreme discharges for small basins, but these errors considerably reduce for basins larger than 30,000 km2 compared to MGB‐MSWEP simulations. Compared to MGB‐ERA5‐Land simulations, MGB‐Eta presents relatively similar errors for basins of different sizes, probably due to the high negative bias for not only extreme but average precipitation as well.