bluuebunny/crossref_metadata_2025_split huggingface dataset:
The linkage of depressive and anxiety disorders with the expected labor market affiliation (ELMA): a longitudinal multi-state study of Danish employees
Authors: Pedersen Jacob , Framke Elisabeth , Thorsen Sannie Vester , Sørensen Kathrine , Andersen Malene Friis , Rugulies Reiner , Solovieva Svetlana 
Published: July 2022

Abstract
Objective
Depressive and anxiety disorders are prevalent among employees in general. Still, knowledge regarding the contribution of these disorders to the dynamics of the labor market in terms of working time, sickness absence, and unemployment is scarce. We aim to quantify the linkage of depressive and anxiety disorders with labor market participation using the expected labor market affiliation method (ELMA), in a large sample of Danish employees.

Methods
We combined three survey waves on occupational health with six high-quality national registers in N = 43,148 Danish employees, of which the 2012 survey contributed 29,665 person years, the 2014 survey 33,043 person years, and the 2016 survey 35,375 person years. We used the new ELMA method to estimate the multi-state transition probabilities and 2-year expected time in work, sickness absence, and unemployment. Depressive and anxiety disorders were assessed by the Major Depression Inventory and the SCL-ANX4 scales, respectively. We adjusted for multiple variables by applying inverse probability weighting in groups of gender and age.

Results
Depressive and anxiety disorders among employees link to reduced labor market affiliation by significantly changed transitions probabilities between the labor markets states, viewed as reduced working time by 4–51 days (in two years), increased time in sickness absence by 6–44 days (in two years), and unemployment by 6–12 days (in two years) when compared to employees without depression or anxiety disorders. The results were most pronounced for women employees and for employees with both depression and anxiety disorders.

Conclusions
The study reveals detailed insight into what extent depression and anxiety disorders influence the labor market affiliation, in terms of the complex interrelation between working time, sickness absence, and unemployment. The study emphasizes the importance of preventing and handling depressive and anxiety disorders among employees for strengthening work participation.
Expert opinion on NSCLC small specimen biomarker testing — Part 2: Analysis, reporting, and quality assessment
Authors: Penault-Llorca Frédérique , Kerr Keith M. , Garrido Pilar , Thunnissen Erik , Dequeker Elisabeth , Normanno Nicola , Patton Simon J. , Fairley Jenni , Kapp Joshua , de Ridder Daniëlle , Ryška Aleš , Moch Holger 
Published: July 2022

Abstract
The diagnostic work-up for non-small cell lung cancer (NSCLC) requires biomarker testing to guide therapy choices. This article is the second of a two-part series. In Part 1, we summarised evidence-based recommendations for obtaining and processing small specimen samples (i.e. pre-analytical steps) from patients with advanced NSCLC. Here, in Part 2, we summarise evidence-based recommendations relating to analytical steps of biomarker testing (and associated reporting and quality assessment) of small specimen samples in NSCLC. As the number of biomarkers for actionable (genetic) targets and approved targeted therapies continues to increase, simultaneous testing of multiple actionable oncogenic drivers using next-generation sequencing (NGS) becomes imperative, as set forth in European Society for Medical Oncology guidelines. This is particularly relevant in advanced NSCLC, where tissue specimens are typically limited and NGS may help avoid tissue exhaustion compared with sequential biomarker testing. Despite guideline recommendations, significant discrepancies in access to NGS persist across Europe, primarily due to reimbursement constraints. The use of increasingly complex testing methods also has implications for the reporting of results. Molecular testing reports should include clinical interpretation with additional commentary on sample adequacy as appropriate. Molecular tumour boards are recommended to facilitate the interpretation of complex genetic information arising from NGS, and to collaboratively determine the optimal treatment for patients with NSCLC. Finally, whichever testing modality is employed, it is essential that adequate internal and external validation and quality control measures are implemented.
The microbial RNA metagenome of Aedes albopictus (Diptera: Culicidae) from Germany
Authors: Rau Janine , Werner Doreen , Beer Martin , Höper Dirk , Kampen Helge 
Published: July 2022

AbstractAedes albopictus is a highly invasive mosquito species that has become widespread across the globe. In addition, it is an efficient vector of numerous pathogens of medical and veterinary importance, including dengue, chikungunya and Zika viruses. Among others, the vector potential of mosquitoes is influenced by their microbiome. However, this influence is very dynamic and can vary between individuals and life stages. To obtain a rough overview on the microbiome of Ae. albopictus populations in Germany, pooled female and pooled male individuals from seven German locations were investigated by total RNA sequencing. The mosquito specimens had been collected as larvae in the field and processed immediately after adult emergence, i.e. without females having fed on blood. RNA fragments with high degrees of identity to a large number of viruses and microorganisms were identified, including, for example, Wolbachia pipientis and Acinetobacter baumannii, with differences between male and female mosquitoes. Knowledge about the natural occurrence of microorganisms in mosquitoes may be translated into new approaches to vector control, for example W. pipientis can be exploited to manipulate mosquito reproduction and vector competence. The study results show how diverse the microbiome of Ae. albopictus can be, and the more so needs to be adequately analysed and interpreted.
Association of change in health-related quality of life and treatment discontinuation in metastatic breast cancer: a post hoc, exploratory analysis of two randomized clinical trials
Authors: Kawahara Takuya , Iwamoto Takayuki , Takashima Ikumi , Hanazawa Ryoichi , Uemura Kohei , Uemura Yukari , Mukai Hirofumi , Kikawa Yuichiro , Taira Naruto 
Published: July 2022

Abstract

Purpose
Identifying factors associated with treatment alteration (treatment discontinuation and dose reduction) may help to attain the treatment goals for metastatic breast cancer. The value of changes in the quality of life (QOL) in predicting treatment alteration remained unclear. This study aimed to examine the relationship between changes in the QOL and treatment alteration of first-line chemotherapy for metastatic breast cancer.

Methods
We merged data from two randomized clinical trials in Japan, conducted from 2006 to 2017, that included patients who were diagnosed with human epidermal growth factor receptor 2-negative and endocrine treatment-resistant breast cancer, with metastatic disease at presentation or recurrence after surgery. The European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 was used to assess QOL. The association between change in time-dependent QOL (worsening by 10-point or not) and time to treatment alteration was assessed using the Cox regression models controlling for patient characteristics (age, liver metastasis, hormone status, and treatment regimen) and baseline QOL.

Results
Worsening physical functioning, global health status, and dyspnea were significantly associated with treatment discontinuation. Worsening role functioning, global health status, and fatigue were significantly associated with dose reduction. The threshold for defining worsening did not have a significant impact on the relationship.

Conclusion
Changes in QOL are associated with the probability of treatment alteration among metastatic breast cancer patients. Physical functioning, role functioning, global health status, dyspnea, and fatigue should be prioritized for symptom management in patients with metastatic breast cancer.
Word imageability influences the emotionality effect in episodic memory
Authors: Ballot Claire , Robert Christelle , Mathey Stéphanie 
Published: July 2022

AbstractThis study examines how and to what extent imageability influences the effect of word emotionality in episodic memory. A total of 52 young adults successively performed a free recall task and a recognition task in which word emotionality and imageability were orthogonally manipulated across six conditions of French words: low-imageability positive words (e.g., éloge [praise]), low-imageability negative words (e.g., viral [viral]), low-imageability neutral words (e.g., global [global]), high-imageability positive words (e.g., ourson [teddy]), high-imageability negative words (e.g., tornade [tornado]), and low-imageability neutral words (e.g., noyau [core]). The results from both the recall and the recognition memory tasks show that word imageability enhances memory performance. Importantly, word imageability interacted with word emotionality in both tasks. Specifically, we found that the advantage of emotional over neutral words in episodic memory performance emerged for high-imageability words only, as did the advantage of positive over negative words. These results highlight the role of imageability in the mechanisms underlying emotional word episodic memory.
Inter- and intra-species heterogeneity in germination of Aspergillus conidia
Authors: Ijadpanahsaravi Maryam , Teertstra Wieke R. , Wösten Han A. B. 
Published: July 2022

AbstractAspergilli are among the most abundant fungi worldwide. They degrade organic material and can be pathogens of plants and animals. Aspergilli spread by forming high numbers of conidia. Germination of these stress resistant asexual spores is characterized by a swelling and a germ tube stage. Here, we show that conidia of Aspergillusniger,Aspergillusoryzae,Aspergillusclavatus, Aspergillusnidulans and Aspergillusterreus show different swelling and germ tube formation dynamics in pure water or in water supplemented with (in)organic nutrients. Apart from inter-species heterogeneity, intra-species heterogeneity was observed within spore populations of the aspergilli except for A.terreus. Sub-populations of conidia differing in size and/or contrast showed different swelling and germ tube formation dynamics. Together, data imply that aspergilli differ in their competitive potential depending on the substrate. Moreover, results suggest that intra-species heterogeneity provides a bet hedging mechanism to optimize survival of aspergilli.
Invading the soundscape: exploring the effects of invasive species’ calls on acoustic signals of native wildlife
Authors: Hopkins Jaimie M. , Edwards Will , Schwarzkopf Lin 
Published: July 2022

AbstractThe transmission and reception of sound, both between conspecifics and among individuals of different species, play a crucial role in individual fitness, because correct interpretation of meaning encoded in acoustic signals enables important context-appropriate behaviours, such as predator avoidance, foraging, and mate location and identification. Novel noise introduced into a soundscape can disrupt the processes of receiving and recognising sounds. When species persist in the presence of novel noise, it may mask the production and reception of sounds important to fitness, and can reduce population size, species richness, or relative abundances, and thus influence community structure. In the past, most investigations into the effects of novel noise have focused on noises generated by anthropogenic sources. The few studies that have explored the effects of calls from invasive species suggest native species alter behaviours (particularly their vocal behaviour) in the presence of noise generated by invasive species. These effects may differ from responses to anthropogenic noises, because noises made by invasive species are biotic in origin, and may therefore be more spectrally similar to the calls of native species, and occur at similar times. Thus, in some cases, negative fitness consequences for native species, associated with noises generated by invasive species, may constitute interspecific competition. Possible negative consequences of invasive species calls represent an overlooked, and underappreciated, class of competitive interactions. We are far from understanding the full extent of the effects of invasive species on native ones. Further investigation of the contribution of noise interference to native species’ decline in the presence of invasive species will significantly increase our understanding of an important class of interactions between invasive and native species.
Free energy: a user’s guide
Authors: Mann Stephen Francis , Pain Ross , Kirchhoff Michael D. 
Published: July 2022

AbstractOver the last fifteen years, an ambitious explanatory framework has been proposed to unify explanations across biology and cognitive science. Active inference, whose most famous tenet is the free energy principle, has inspired excitement and confusion in equal measure. Here, we lay the ground for proper critical analysis of active inference, in three ways. First, we give simplified versions of its core mathematical models. Second, we outline the historical development of active inference and its relationship to other theoretical approaches. Third, we describe three different kinds of claim—labelled mathematical, empirical and general—routinely made by proponents of the framework, and suggest dialectical links between them. Overall, we aim to increase philosophical understanding of active inference so that it may be more readily evaluated. This paper is the Introduction to the Topical Collection “The Free Energy Principle: From Biology to Cognition”.
Good Intentions Gone Awry: Government Intervention and Multistakeholder Engagement in a Frontier Market
Authors: Segaro Ethiopia L. , Haag Kajsa 
Published: July 2022

AbstractHow to achieve sustainable communities with decent work and economic growth without negative environmental impact, is at the heart of the United Nations Sustainable Development Goals and a top priority of many governments around the world. This article critically explores the role of government intervention for achieving sustainable local prosperity in frontier markets of developing countries, where such advancement is especially crucial. More specifically, we explore by an in-depth case study how multiple stakeholders cooperate to enhance local development and export from firms in the leather and leather products industry in Ethiopia. From a multistakeholder engagement perspective, including representatives of local businesses, United Nations, Ministry of Trade and Industry, and other development partners, we analyze how government interventions have resulted in unintended outcomes despite their good intention. We contribute with a new understanding of why development initiatives in frontier markets struggle with stakeholder integration, caused by power asymmetry and lack of institutional trust which prevents the achievements of sustainable development goals. Contextualized implications for firms, government, and non-governmental actors on how to improve collaboration are provided, and policy implications are proposed.
Left atrial strain and recurrence of atrial fibrillation after thoracoscopic surgical ablation: a subanalysis of the AFACT study
Authors: Baalman Sarah W. E. , van den Berg Nicoline W. E. , Neefs Jolien , Berger Wouter R. , Meulendijks Eva R. , de Bruin-Bon Rianne H. A. C. M. , Bouma Berto J. , van Boven Wim Jan P. , Driessen Antoine H. G. , de Groot Joris R. 
Published: July 2022

AbstractTo assess transthoracic echocardiographic (TTE) left atrial (LA) strain parameters and their association with atrial fibrillation (AF) recurrence after thoracoscopic surgical ablation (SA) in patients in sinus rhythm (SR) or in AF at baseline. Patients participating in the Atrial Fibrillation Ablation and Autonomic Modulation via Thoracoscopic Surgery trial were included. All patients underwent thoracoscopic pulmonary vein isolation with LA appendage exclusion and were randomized to ganglion plexus (GP) or no GP ablation. In TTEs performed before surgery, LA strain and mechanical dispersion (MD) of the LA reservoir and conduit phase in all patients, and of the contraction phase in patients in SR were obtained. Recurrence of AF was defined as any documented atrial tachyarrhythmia lasting > 30 s during one year of follow-up. Two hundred and four patients (58.6 ± 7.8 years, 73% male, 57% persistent AF) were included. At baseline TTE 121 (59%) were in SR and 83 (41%) had AF. Patients with AF recurrence had lower LA strain of the reservoir phase (13.0% vs. 16.6%; p =  < 0.001) and a less decrease in strain of the conduit phase (−9.0% vs. −11.8%; p = 0.006), regardless of rhythm. MD of the conduit phase was larger in patients with AF recurrence (79.4 vs. 43.5 ms; p = 0.012). Multivariate cox regression analysis demonstrated solely an association between LA strain of the reservoir phase and AF recurrence in patients in SR (HR 0.95, p = 0.046) or with AF (HR 0.90, p = 0.038). A reduction in LA strain of the reservoir phase prior to SA predicts recurrence of AF in both patients with SR or AF. Left atrial strain assessment may therefore add to a better patient selection for SA.
The effect of ionic strength and pH on the dewatering rate of cellulose nanofibril dispersions
Authors: Fall Andreas , Henriksson Marielle , Karppinen Anni , Opstad Anne , Heggset Ellinor B. , Syverud Kristin 
Published: July 2022

Abstract
Cellulose nanofibrils, CNFs, show great potential in many application areas. One main aspect limiting the industrial use is the slow and energy demanding dewatering of CNF suspensions. Here we investigate the dewatering with a piston press process. Three different CNF grades were dewatered to solid contents between approx. 20 and 30%. The CNF grades varied in charge density (30, 106 and 604 µmol/g) and fibrillation degree. The chemical conditions were varied by changing salt concentration (NaCl) and pH and the dewatering rates were compared before and after these changes. For the original suspensions, a higher charge provides slower dewatering with the substantially slowest dewatering for the highest charged CNFs. However, by changing the conditions it dewatered as fast as the two lower charged CNFs, even though the salt/acid additions also improved the dewatering rate for these two CNFs. Finally, by tuning the conditions, fast dewatering could be obtained with only minor effect on film properties (strength and oxygen barrier) produced from redispersed dispersion. However, dewatering gives some reduction in viscosity of the redispersed dispersions. This may be a disadvantage if the CNF application is as e.g. rheology modifier or emulsion stabilizer.

Graphical abstract
Enhancement of Protocols for Simple Shear of Isotropic Soft Hyperelastic Samples
Authors: Horgan C. O. , Murphy J. G. 
Published: July 2022

AbstractThe classic deformation known as simple shear has been investigated within the framework of nonlinear elasticity for isotropic incompressible hyperelastic materials in a large variety of contexts, most notably in the analysis of the mechanical behaviour of soft matter. One of the major difficulties in providing a realistic physical interpretation of this idealised homogeneous deformation is the fact that the conventional mathematical model of simple shear using a plane stress assumption to determine the hydrostatic pressure implies that a normal traction must be applied to the slanted faces of the deformed specimen. However, such a traction is not applied in practice. To resolve this dilemma, we retain the classic plane stress assumption to determine the hydrostatic pressure but modify the basic kinematics to consider a simple shear deformation superposed on a uniform lateral extension or compression of the specimen. The amount of lateral stretch is treated as a stabilising factor determined so that the predicted normal traction is minimised and thus the fidelity of the model with experimental protocols is enhanced. This new approach is illustrated for a variety of classical strain-energy densities for isotropic hyperelastic materials that have been used to model the mechanical behaviour of soft matter.
Diffusion of renewable energy technology on Spanish farms: drivers and barriers
Authors: Pombo-Romero Julio , Langeveld Hans , Fernández-Redondo Marta 
Published: July 2022

AbstractThe aim of this paper is to identify the drivers and barriers of on-farm adoption of renewable energy systems (RES) in Spain and to determine how the existing mix of policies (subsidies, regulation and communication) affected the decisions of the farmers. The analysis is based on the results of a national survey that was completed by 719 farmers, representing the main types of farms and production regions. Statistically significant correlations have been observed between the probability of on-farm RES adoption and variables such as the use of contract farming, interest in new technologies and risk tolerance. Findings suggest that the diffusion of on-farm RES was at an early stage. Farmers are hesitant to adopt RES because the level of economic and regulatory uncertainty is perceived as too high in relation to the return and payback time typical of RES investments. Tailored business models and financing solutions should be implemented and promoted to overcome the described issues. Furthermore, relevant and reliable information should be available within farmers’ most common professional networks such as cooperatives and farmers’ associations. These aspects should be combined or even prioritized over providing direct economic incentives when producing on-farm RES supporting policies.
Solving the grand challenge of phenotypic integration: allometry across scales
Authors: Vasseur François , Westgeest Adrianus Johannes , Vile Denis , Violle Cyrille 
Published: July 2022

AbstractPhenotypic integration is a concept related to the cascade of trait relationships from the lowest organizational levels, i.e. genes, to the highest, i.e. whole-organism traits. However, the cause-and-effect linkages between traits are notoriously difficult to determine. In particular, we still lack a mathematical framework to model the relationships involved in the integration of phenotypic traits. Here, we argue that allometric models developed in ecology offer testable mathematical equations of trait relationships across scales. We first show that allometric relationships are pervasive in biology at different organizational scales and in different taxa. We then present mechanistic models that explain the origin of allometric relationships. In addition, we emphasized that recent studies showed that natural variation does exist for allometric parameters, suggesting a role for genetic variability, selection and evolution. Consequently, we advocate that it is time to examine the genetic determinism of allometries, as well as to question in more detail the role of genome size in subsequent scaling relationships. More broadly, a possible—but so far neglected—solution to understand phenotypic integration is to examine allometric relationships at different organizational levels (cell, tissue, organ, organism) and in contrasted species.