bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bas-relief modeling from RGB monocular images with regional division characteristics
Authors: Wu Xinli , Zhao Yun , Luo Jiali , Zhang Minxiong , Yang Wenzhen 
Published: December 2022

AbstractTraditional Bas-relief modeling methods are often limited to inefficient and difficult to be altered after the product is formed. This paper presents a novel method for bas-relief modeling from RGB monocular images with regional division characteristics. The problem discussed in this paper involves edge detection, region division, height value recovery and three-dimensional reconstruction of image. In our framework, we can automatically obtain the pixel height of each area in the image and can adjust the concave–convex relationship of each image area to obtain a bas-relief modeling which can be printed directly in 3D. The edge detection algorithm used Gaussian difference pyramid to combine the luminance information and chrominance information of digital image; the regions of the RGB monocular image are divided by the improved connected-component labeling algorithm;and the 3D pixel point cloud of each region is calculated by the shape-from-shading algorithm. Different from previous work, our method can fully obtain the image height field data and completely restored the depth information,which makes it possible to use any RGB monocular image for bas-relief modeling. Experiments with groups of images show that our method can effectively generate bas-relief modeling.
Mild shading promotes sesquiterpenoid synthesis and accumulation in Atractylodes lancea by regulating photosynthesis and phytohormones
Authors: Guo Xiuzhi , Li Qiang , Yan Binbin , Wang Yuefeng , Wang Sheng , Xiong Feng , Zhang Chengcai , Zhang Yan , Guo Lanping 
Published: December 2022

AbstractAtractylodes lancea rhizome (AR) has high medicinal and economic value. A previous study has reported that the accumulation of sesquiterpenoids in AR has obvious advantages under bamboo canopy. A concrete shade value to promote the cultivation of high-quality AR has not been established. In this study, 80% shading was screened at six different light intensities (100%, 80%, 60%, 40%, 20%, 7%), and the mechanism was explored in terms of photosynthetic efficiency and phytohormones levels. The results indicated that the total sesquiterpenoid content of 80% mild shading increased by 58%, 52%, and 35%, respectively, compared to 100% strong light in seedling, expansion, and harvest stages and increased by 144%, 178%, and 94%, respectively, compared with 7% low light. The sesquiterpenoids hinesol and β-eudesmol contributed approximately 70% to the differential contribution ratio between mild shading and strong light (100%) or between mild shading and low light (7%). Furthermore, HMGR, DXR, and FPPS genes, which regulate sesquiterpenoid synthesis, were significantly upregulated in 80% mild shading. Transpiration rate; the intercellular CO2 concentration; net photosynthetic rate; and levels of jasmonic acid, abscisic acid, and gibberellin were strongly correlated (r > 0.85) with sesquiterpenoid accumulation. Cis-acting elements responding to light and phytohormones were present within the promoter regions of HMGR, DXR, and FPPS. Therefore, 80% shading promotes the synthesis and accumulation of sesquiterpenoids in AR by regulating photosynthetic efficiency and phytohormone production, thereby promoting transcriptional expression.
The effect of perceptual expectation on processing gain, attention and the perceptual decision bias in children and adolescents with Autism Spectrum Disorder (ASD)
Authors: Boxhoorn Sara , Schütz Magdalena , Mühlherr Andreas M. , Mössinger Hannah , Luckhardt Christina , Freitag Christine M. 
Published: December 2022

AbstractPerceptual expectations influence perception, attention and the perceptual decision bias during visuospatial orienting, which is impaired in individuals with Autism Spectrum Disorder (ASD). In this study, we investigated whether during visuospatial orienting, perceptual expectations in ASD differentially influence perception, attention and the perceptual decision bias relative to neurotypical controls (NT). Twenty-three children and adolescents with ASD and 23 NT completed a visuospatial orienting task, which compared the effect of a valid relative to an invalid perceptual expectation on target detection (cue validity effect). Group differences were calculated regarding the cue validity effect on neural correlates of processing gain (N1a amplitude) and attention (N1pc amplitude), the perceptual decision bias and mean reaction time (RT). In ASD relative to NT, findings showed a reduced processing gain for validly relative to invalidly cued targets and increased attentional response following invalidly relative to validly cued targets. Increased attention correlated with faster performance across groups. Increased processing correlated with a higher perceptual decision bias and faster mean RT in NT, but not in ASD. Results suggest that during visuospatial orienting, perceptual expectations in ASD may drive changes in sensory processing and stimulus-driven attention, which may differentially guide behavioural responses.
Utilizing volatile organic compounds for early detection of Fusarium circinatum
Authors: Nordström Ida , Sherwood Patrick , Bohman Björn , Woodward Stephen , Peterson Donnie L. , Niño-Sánchez Jonatan , Sánchez-Gómez Tamara , Díez Julio Javier , Cleary Michelle 
Published: December 2022

AbstractFusarium circinatum, a fungal pathogen deadly to many Pinus species, can cause significant economic and ecological losses, especially if it were to become more widely established in Europe. Early detection tools with high-throughput capacity can increase our readiness to implement mitigation actions against new incursions. This study sought to develop a disease detection method based on volatile organic compound (VOC) emissions to detect F. circinatum on different Pinus species. The complete pipeline applied here, entailing gas chromatography—mass spectrometry of VOCs, automated data analysis and machine learning, distinguished diseased from healthy seedlings of Pinus sylvestris and Pinus radiata. In P. radiata, this distinction was possible even before the seedlings became visibly symptomatic, suggesting the possibility for this method to identify latently infected, yet healthy looking plants. Pinus pinea, which is known to be relatively resistant to F. circinatum, remained asymptomatic and showed no changes in VOCs over 28 days. In a separate analysis of in vitro VOCs collected from different species of Fusarium, we showed that even closely related Fusarium spp. can be readily distinguished based on their VOC profiles. The results further substantiate the potential for volatilomics to be used for early disease detection and diagnostic recognition.
Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy
Authors: Kendall Alexandra C. , Pilkington Suzanne M. , Wray Jonathan R. , Newton Victoria L. , Griffiths Christopher E. M. , Bell Mike , Watson Rachel E. B. , Nicolaou Anna 
Published: December 2022

AbstractThe menopause can lead to epidermal changes that are alleviated by hormone replacement therapy (HRT). We hypothesise that these changes could relate to altered ceramide production, and that oestrogen may have a role in keratinocyte ceramide metabolism. White Caucasian women were recruited into three groups: pre-menopausal (n = 7), post-menopausal (n = 11) and post-menopausal taking HRT (n = 10). Blood samples were assessed for hormone levels, transepidermal water loss was measured to assess skin barrier function, and stratum corneum lipids were sampled from photoprotected buttock skin. Ceramides and sphingomyelins were analysed by ultraperformance liquid chromatography with electrospray ionisation and tandem mass spectrometry. Post-menopausal stratum corneum contained lower levels of ceramides, with shorter average length; changes that were not evident in the HRT group. Serum oestradiol correlated with ceramide abundance and length. Ceramides had shorter sphingoid bases, indicating altered de novo ceramide biosynthesis. Additionally, post-menopausal women had higher sphingomyelin levels, suggesting a possible effect on the hydrolysis pathway. Treatment of primary human keratinocytes with oestradiol (10 nM) increased production of CER[NS] and CER[NDS] ceramides, confirming an effect of oestrogen on cutaneous ceramide metabolism. Taken together, these data show perturbed stratum corneum lipids post-menopause, and a role for oestrogen in ceramide production.
Sense of agency may not improve recollection and familiarity in recognition memory
Authors: Tsuji Nanami , Imaizumi Shu 
Published: December 2022

AbstractSense of agency (SoA) is a feeling of controlling one’s own action. Recognition memory can improve for stimuli that involve SoA perhaps because of the self-reference effect. Recognition memory consists of recollection (i.e., detailed memory of stimuli) and familiarity (i.e., a feeling that stimuli are in memory). The self-reference effect is often observed in the recollection. Here, we investigated whether SoA particularly improves the recollection process. Participants pressed a key to produce an outcome (i.e., box movement followed by word presentation in Experiment 1 or word presentation in Experiment 2) and rated their SoA over the outcome. The outcome was spatially congruent or incongruent with the action. The participants learned the words intentionally (Experiment 1) or incidentally (Experiment 2). Performances of recollection and familiarity were assessed using the remember/know procedure. Our results suggest that the participants’ SoA was successfully manipulated. However, contrary to our hypothesis and previous findings, we found no effects of voluntary action and action–outcome congruence on recollection and familiarity processes of recognition memory, regardless of the latency of word presentation and learning strategies. Further studies are needed to replicate and elucidate the relationship between the SoA and recognition memory.
The module triad: a novel network biology approach to utilize patients’ multi-omics data for target discovery in ulcerative colitis
Authors: Voitalov Ivan , Zhang Lixia , Kilpatrick Casey , Withers Johanna B. , Saleh Alif , Akmaev Viatcheslav R. , Ghiassian Susan Dina 
Published: December 2022

AbstractTumor necrosis factor-$$\alpha $$
α
inhibitors (TNFi) have been a standard treatment in ulcerative colitis (UC) for nearly 20 years. However, insufficient response rate to TNFi therapies along with concerns around their immunogenicity and inconvenience of drug delivery through injections calls for development of UC drugs targeting alternative proteins. Here, we propose a multi-omic network biology method for prioritization of protein targets for UC treatment. Our method identifies network modules on the Human Interactome—a network of protein-protein interactions in human cells—consisting of genes contributing to the predisposition to UC (Genotype module), genes whose expression needs to be modulated to achieve low disease activity (Response module), and proteins whose perturbation alters expression of the Response module genes to a healthy state (Treatment module). Targets are prioritized based on their topological relevance to the Genotype module and functional similarity to the Treatment module. We demonstrate utility of our method in UC and other complex diseases by efficiently recovering the protein targets associated with compounds in clinical trials and on the market . The proposed method may help to reduce cost and time of drug development by offering a computational screening tool for identification of novel and repurposing therapeutic opportunities in UC and other complex diseases.
Changes in land-atmosphere coupling increase compound drought and heatwaves over northern East Asia
Authors: Seo Ye-Won , Ha Kyung-Ja 
Published: December 2022

AbstractCompound drought and heatwaves (DHW) events have much attention due to their notable impacts on socio-ecological systems. However, studies on the mechanisms of DHW related to land-atmosphere interaction are not still fully understood in regional aspects. Here, we investigate drastic increases in DHW from 1980 to 2019 over northern East Asia, one of the strong land-atmosphere interaction regions. Heatwaves occurring in severely dry conditions have increased after the late 1990s, suggesting that the heatwaves in northern East Asia are highly likely to be compound heatwaves closely related to drought. Moreover, the soil moisture–temperature coupling strength increased in regions with strong increases in DHW through phase transitions of both temperature and heat anomalies that determine the coupling strength. As the soil moisture decreases, the probability density of low evapotranspiration increases through evaporative heat absorption. This leads to increase evaporative stress and eventually amplify DHW since the late 1990s. In particular, seasonal changes in soil moisture and evapotranspiration between spring and summer contributed to the amplification of DHW by enhancing land-atmosphere interaction.
Emerging health threat and cost of Fusarium mycotoxins in European wheat
Authors: Johns Louise E. , Bebber Daniel P. , Gurr Sarah J. , Brown Neil A. 
Published: December 2022

AbstractMycotoxins harm human and livestock health, while damaging economies. Here we reveal the changing threat of Fusarium head blight (FHB) mycotoxins in European wheat, using data from the European Food Safety Agency and agribusiness (BIOMIN, World Mycotoxin Survey) for ten years (2010–2019). We show persistent, high, single- and multi-mycotoxin contamination alongside changing temporal-geographical distributions, indicative of altering FHB disease pressure and pathogen populations, highlighting the potential synergistic negative health consequences and economic cost.
Advanced algorithms for optimal meeting points in road networks
Authors: Liu Kaijun , Liu Jianming , Zhang Jingwei 
Published: December 2022

AbstractAn optimal meeting point query is used to determine a location in a spatial region to build a new facility that minimizes the sum of the (weighted) road distances from all clients. This problem has been studied in previous work with the assumption that all clients and facilities reside in Euclidean space or along road networks. However, due to the limitations of geographic information system technologies, it is difficult to return an exact geographic location to answer the optimal meeting point query based on a set of arbitrary coordinates. This issue results in various problems, such as positioning and measurement errors, in practical use. In this paper, it is aimed to identify the optimal meeting point in road networks for clients and facilities residing in non‐Euclidean spaces. Two efficient heuristic solutions are proposed based on approximate and adaptive query processing techniques by using randomized adaptive search and random direction search methods, respectively, to rapidly converge to the global optimum in the geographic coordinate system. Extensive experiments based on real datasets demonstrate that our proposed method achieves a 32.11% improvement over the state‐of‐the‐art approach.
Der Einsatz der Ozon-Sauerstoff-Therapie in der ärztlichen Praxis für Naturheilverfahren
Authors: Schreiber Michael 
Published: December 2022

SummaryDie Ozon-Sauerstoff-Therapie hat sich in der Praxis des Autors seit Jahrzehnten bewährt als ideale Ergänzung zu vielen Naturheilverfahren. Er beschreibt aus praktischer Sicht das Vorgehen. Sehr bewährt hat sich die Ozon-Sauerstoff-Therapie bei Erschöpfungszuständen, Durchblutungsstörungen, rheumatischen Erkrankungen und Immundefizitproblemen. Der Autor setzt sie auch bei Long-Covid-Patienten ein.
Ultraviolettbestrahlung des Blutes: Theorie, Technik, Praxis
Authors: Sauer Helmut 
Published: December 2022

SummaryBei der Ultravioletttherapie wird das Blut der Patienten mit UV-Licht behandelt und dann re-injiziert. Ziel ist es, dass das Immunsystem das behandelte Blut als Fremdkörper erkennt und dadurch das Immunsystem stimuliert wird. Einsatzgebiete der UV-Behandlung sind zum Beispiel Herzerkrankungen, zerebrovaskuläre Störungen, Durchblutungsstörungen, diabetische Retinopathie oder chronisch-entzündliche Erkrankungen. 2 Fallbeispiele demonstrieren den Effekt der UV-Therapie bei Durchblutungsstörungen und Makuladegeneration.
Frequent User mit Angststörung in der Berliner Notfallrettung: Analyse von Notrufverhalten, Diagnosegruppe und urbaner Verteilung
Authors: Breuer Florian , Dahmen Janosch , Pommerenke Christopher , Poloczek Stefan 
Published: December 2022

Zusammenfassung
Einleitung Patienten mit Angststörung machen einen wesentlichen Anteil derjenigen Anrufer aus, die den Rettungsdienst in Anspruch nehmen. Es ist davon auszugehen, dass viele dieser
Patienten als Frequent User wiederholt den Rettungsdienst alarmieren.
Methodik Als Frequent User mit Angststörung wurden diejenigen Patienten definiert, bei denen im Einsatzprotokoll die Kombination aus der (Verdachts-)Diagnose „Psychiatrischer
Notfall“ sowie dem psychiatrischen Befund „ängstlich“ dokumentiert wurde und es im betrachteten Zeitraum (01.1.2020 bis 31.5.2021) zu mindestens 2 Einsätzen der Notfallrettung kam
(n = 74).
Ergebnisse Die Alarmierung erfolgte in 31% zum psychiatrischen Notfall, aber auch zu Herzbeschwerden, Atembeschwerden oder Brustschmerzen. Bei 56,4% der Einsätze wurde als
Hauptdiagnose eine psychiatrische Erkrankung angegeben, bei 43,6% eine sonstige Erkrankung. Ein Zusammenhang zwischen der Einsatzhäufigkeit und dem Patientenalter oder dem Wochentag
bestand nicht. Im Stadtgebiet kam es zwar in einzelnen Bereichen mit Status-Index 4 (sehr niedriger sozialer Status) zu vermehrten Einsätzen, insgesamt zeigte sich jedoch eine gleichmäßige
Verteilung im Stadtgebiet.
Schlussfolgerung Der wiederholte Transport in ein Krankenhaus kann bei Frequent Usern mit Angststörung einen erneuten Notruf nach sich ziehen. Ein Case Management könnte dazu
beitragen, die Einsatzzahlen zu reduzieren und Frequent User mit Angststörung an geeignete Versorgungsformen anzubinden.
Die Therapie des Sympathikus: eine manualtherapeutische Methode am Beispiel des Reizdarmsyndroms – eine Pilotstudie
Authors: Heesch Dieter , Loudovici-Krug Dana , Best Norman 
Published: December 2022

SummaryIn einer Pilotstudie wurden 30 Patient*innen mit RDS-Beschwerden einmalig mittels Therapie des Sympathikus, einer speziellen Mobilisation des achten Brustwirbels, behandelt. Das „Irritable Bowel Syndrome – Severity Scoring System“ (IBS–SSS) dienteals Messinstrument. Als chronisches Beschwerdebild könnte das RDS seine Ursache in einem übermäßig erregten Sympathikus haben. Mit der Therapie des Sympathikus kann darauf gezielt Einfluss genommen werden. Da in der vorliegenden Studie diese regulatorische Therapieform nur einmalig angewendet wurde, ist weitere Forschung mit einem verlängerten Interventionszeitraum oder bei wiederholter Therapie anzustreben, um insbesondere Aussagen zur langfristigen Wirksamkeit treffen zu können.
Variation and change in the sociophonetic variable ing in format ties
Authors: Eiswirth Mirjam Elisabeth , Bergmann Felix 
Published: December 2022

Abstract
Format ties, “partial repetitions of prior talk” (Goodwin & Goodwin
1987, p. 207), are interesting from an interactional perspective with respect to their functions relating to, for
example, (dis-) agreement/alignment or humour, and for scholars of Language Variation and Change because they offer uniquely
comparable phonological contexts in naturalistic speech. The present paper investigates the distribution of the sociolinguistic
variable ing in format ties in a set of dyadic interviews of six speakers from the North-East of England who were
recorded two or three times throughout their twenties – those career-building years during which we often see a change from the
predominant use of the alveolar variant (“in’”) to the velar (“ing”).
The analysis offers possible interactional and stylistic explanations for the community-level stability and the
speaker-level variation and change of ing by focusing on contexts in which speakers format tie. It shows that the
use of the highly frequent and thus less marked alveolar variant tends to occur in aligning contexts, while the few velar cases
occur in moments where speakers disalign on some level. This argument contributes to work combining interactional and variationist
endeavours, in particular with respect to the variable ing.
A plea for integrated empirical and philosophical research on the impacts of feminized AI workers
Authors: Read Hannah , Gomez-Lavin Javier , Beltrama Andrea , Miracchi Titus Lisa 
Published: December 2022

AbstractFeminist philosophers have long emphasized the ways in which women’s oppression takes a variety of forms depending on complex combinations of factors. These include women’s objectification, dehumanization and unjust gendered divisions of labour caused in part by sexist ideologies regarding women’s social role. This paper argues that feminized artificial intelligence (feminized AI) poses new and important challenges to these perennial feminist philosophical issues. Despite the recent surge in theoretical and empirical attention paid to the ethics of AI in general, a strikingly small portion of this work has considered the impact of feminized AI in particular. Our aim is thus to draw attention to the new and pressing ethical challenges posed by feminized AI. Doing so is crucial not just to understanding the impact of these increasingly ubiquitous technologies, but also to our understanding of longstanding feminist philosophical concerns and efforts to ameliorate them.
466 OUT-OF-HOSPITAL CARDIAC ARREST: UNIVERSITY OF TRIESTE STUDENTS’ KNOWLEDGE OF CARDIOPULMONARY RESUSCITATION AND DEFIBRILLATOR USE
Authors: Marcori Sara , Pezzato Andrea , Cano Ana Karina Hinojosa , Gant Alessia , Uliana Andrea , Koni Miranda , Rakar Serena , Aneta Aleksova , Sinagra Gianfranco , Merlo Marco 
Published: December 2022

Abstract

Background
Out-of-hospital cardiac arrest (OHCA) is the third leading cause of death in industrialized countries. Although most cardiac arrests are witnessed, survival is only 2-10%, since bystanders are often unable to correctly perform cardio-pulmonary resuscitation (CPR). This study aims to assess the theoretical and practical knowledge of CPR and the use of the automatic external defibrillator (AED) in university students.

Materials and methods
The study involved a total of 1686 students from 21 different faculties of the University of Trieste, 662 students from health faculties and 1024 from non-health faculties. Basic life support and early defibrillation (BLSD) courses have been included in health faculties and made mandatory for students in their final years. Through the platform “EUSurvey” from March to June 2021, they were given an online questionnaire of 25 multiple choice questions to investigate the performance of BLSD.

Results
In the overall population, only 68.7% knew how to diagnose a cardiac arrest and the 47.5% knew the time frame after which irreversible brain damage occurs. Practical knowledge was analysed by evaluating the correct answers to all four questions on performing CPR (hand position during compressions, frequency of compressions, depth of compressions, and ventilations-compressions ratio). Health faculties students have better theoretical and practical knowledge of CPR than their colleagues in non-health faculties (11,2% vs 4,3%; p value &lt;0.001). Final-year medical students, who attended the BLSD course and underwent retraining, have achieved better results than first year medical students (38,1% vs 2,7%; p value &lt;0.001).

Discussion
The knowledge of cardiac arrest needs to be improved in the overall university population. The obligatory inclusion of BLSD courses in healthcare degree courses has led to a significant increase in knowledge on the issue. Given this, we believe it is important to extend these courses to all university students.