bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ứng dụng tiêu chuẩn phân loại mức độ COVID-19 của Bộ Y tế năm 2022 trong tiên lượng nguy cơ tử vong
Authors: Đức Đặng Phúc Đức , Nguyễn Thị Thu Huyền Nguyễn Thị Thu Huyền , Trừ Thị Hương Trừ Thị Hương , Nguyễn Thị Thúy Quỳnh Nguyễn Thị Thúy Quỳnh , Nguyễn Ngọc Hiển Nguyễn Ngọc Hiển , Nguyễn Văn Thiện Nguyễn Văn Thiện 
Published: September 2022

Mục tiêu: Đánh giá hiệu quả tiên lượng tử vong người bệnh (NB) COVID-19 bằng tiêu chuẩn phân loại mức độ bệnh COVID-19 của Bộ Y tế năm 2022. Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang trên 376 NB tại Bệnh viện Dã chiến Truyền nhiễm số 5G. Có 68/376 (18,1%) NB tử vong (TV). Tỷ lệ người bệnh từ ≥ 60 tuổi chiếm 49,7%; trong đó nhóm TV 79,4%, nhóm không tử vong (KTV) 43,2%. Kết quả và kết luận: Triệu chứng rối loạn ý thức tăng nguy cơ tử vong với OR = 4,80 (p < 0,05); khó thở khi nhập viện OR = 8,67 với p < 0,05; chỉ số SpO2 ≤ 96% OR = 3,98 với p < 0,05. Tỷ lệ NB tổn thương > 50% trường phổi chiếm 54,3%. Trong đó nhóm TV 76,5%, cao hơn nhóm KTV (49,4%), khác biệt có ý nghĩa thống kê (YNTK) (p < 0,05). Tỷ lệ tử vong tăng dần theo mức độ bệnh COVID-19. Đặc biệt ở nhóm NB mức độ nguy kịch, tỷ lệ tử vong lên tới 66,7%.
* Từ khóa: COVID-19; Mức độ COVID-19; Hướng dẫn chẩn đoán và điều trị COVID-19 của Bộ Y tế.
Nghiên cứu mối liên quan giữa biến đổi điện não đồ và đặc điểm lâm sàng ở bệnh nhân rối loạn trầm cảm
Authors: Đỗ Xuân Tĩnh Đỗ Xuân Tĩnh , Nguyễn Thị Tám Nguyễn Thị Tám , Đinh Việt Hùng Đinh Việt Hùng 
Published: September 2022

Mục tiêu: Mô tả điện não đồ và tìm hiểu mối liên quan giữa biến đổi điện não đồ với đặc điểm lâm sàng ở bệnh nhân (BN) rối loạn trầm cảm (RLTC). Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang trên 48 BN RLTC điều trị nội trú tại Khoa Tâm thần, Bệnh viện Quân y 103. Kết quả: 72,9% BN trầm cảm có điện não đồ biến đổi. Chỉ số trung bình của sóng alpha 37 ± 13%, sóng beta tăng chỉ số 70 ± 19%, xuất hiện lan tỏa hai bán cầu, có xuất hiện sóng chậm theta với chỉ số 10,28 ± 2,67%. 83,3% BN có điện não mất cân đối giữa hai bán cầu có triệu chứng ngại tiếp xúc với xung quanh. Trong nhóm BN mất đối xứng sóng alpha trên điện não đồ; 88,9% BN có thời gian bị bệnh < 3 năm; 83,3% BN có triệu chứng suy nghĩ miên man trước khi ngủ có sóng beta lan tỏa khắp hai bán cầu. Kết luận: Điện não đồ giảm chỉ số sóng alpha, sóng beta lan tỏa hai bán cầu, tính chất mất đối xứng của sóng alpha và lan tỏa của sóng beta hai bán cầu liên quan tới thời gian bị bệnh và một số triệu chứng trên lâm sàng.
* Từ khóa: Điện não đồ; Rối loạn trầm cảm.
Nghiên cứu giá trị của thang điểm ALBI trong tiên lượng xuất huyết tiêu hóa cấp do vỡ giãn tĩnh mạch thực quản ở bệnh nhân xơ gan
Authors: Nguyễn Văn Chung Nguyễn Văn Chung , Đào Đức Tiến Đào Đức Tiến , Dương Quang Huy Dương Quang Huy 
Published: September 2022

Mục tiêu: Đánh giá giá trị của thang điểm ALBI (Albumin-Bilirubin) trong tiên lượng tái chảy máu sớm và tử vong ở bệnh nhân (BN) xơ gan tại bệnh viện trong xuất huyết tiêu hóa (XHTH) do vỡ giãn tĩnh mạch thực quản (TMTQ). Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang trên 222 BN xơ gan có biến chứng XHTH cấp do vỡ giãn TMTQ điều trị tại Khoa Nội tiêu hóa, Khoa Hồi sức cấp cứu nội - Bệnh viện Quân y 103 và Viện điều trị các bệnh Tiêu hóa - Bệnh viện Trung ương Quân đội 108 từ tháng 9/2020 đến tháng 5/2022. Tính điểm ALBI và đối chiếu với tỷ lệ tái chảy máu sớm và tử vong tại bệnh viện. Kết quả: Thang điểm ALBI có giá trị tốt trong tiên lượng tử vong nội viện (AUROC 0,81; 95%CI = 0,68 - 0,93; p < 0,001), tại điểm cắt -0,97 có độ nhạy 80,0% và độ đặc hiệu 75,0%; có giá trị khá trong dự đoán tái chảy máu sớm (AUROC 0,74; 95%CI = 0,63 - 0,85; p < 0,001), tại điểm cắt -1,16 có độ nhạy 75,0% và độ đặc hiệu 65,0%. Kết luận: ALBI là thang điểm có giá trị trong tiên lượng nguy cơ tái chảy máu và tử vong tại bệnh viện ở BN xơ gan có biến chứng XHTH cấp do vỡ giãn TMTQ.
* Từ khóa: Thang điểm ALBI; XHTH do vỡ giãn TMTQ; Xơ gan.
Review of Optical Diagnostic Technique for Diesel Spray
Authors: Ihwan Ghazali  , La Ode Mohammad Firman  , Handi  , Yusrizal  , Ayu Amanah  , Mohammed Bashir Abdulrahman  
Published: September 2022

To enhance the fuel efficiency and reduce both NOX and soot emissions in diesel engine, it is essential to understand the mixture formation and the combustion process in the cylinder. The injection parameters such as pressure, mass and multiple approaches as well as the impingement play an important role in mixture formation, combustion process and emissions. Previous works have addressed various optical diagnostic techniques. This review describes those factors mentioned above systematically to clarify the diesel spray in the compression ignition engine. Therefore, a diesel vehicle with better fuel economy and low emission that meets the stringent regulation across the world could be realized.
Literature Study on Science Learning Media in Elementary School
Authors: Widyaningrum Fika Ari , Maryani Ika , Vehachart Rungchatchadaporn 
Published: September 2022

This study aims to discover the development of research on elementary science learning media in 2017-2021 and find future research opportunities in elementary science learning media. The type of research used is descriptive quantitative using bibliometric analysis assisted by VOSviewer and Mendeley software. This research data is in the form of 111 research journal articles on elementary science learning media conducted in Indonesia and sourced from several SINTA 1-6 journals in the 2017-2021 timeframe. From the study results, the development of research on elementary science learning media was the highest in 2018. Opportunities for learning media research topics can still be done by selecting keywords rarely used by previous researchers, namely training, science abstract, learning independence, science process skills, cartoons, flashcards, index card matches, puzzles, mastery of concepts, and monopoly games. You can also choose topics with the latest discussion trends using articulate storyline keywords, media development, STEM-based science learning, 21st century, Canva, application of learning media, wonder share, software, mobile learning, monopoly games, mastery of concepts, en-alter source, animation, online, discovery learning, interest and learning outcomes, animated videos, and development models.
Features of the poetics of the medieval collection of prose "Roman Deeds" (studying a new book by Svetlana Neretina "No word is better than another". Philosophy and Literature")
Authors: Rozin Vadim Markovich 
Published: September 2022

The article offers an analysis of the poetics of the collection of prose "Roman Deeds", which the author considers as an addition to the study of S.S. Neretina. First, the methodology of studying medieval texts, which is discussed in the "Preface" to the book, is briefly characterized, and two stories from the collection are given as cases. Neretina argues that the "Roman Acts" expresses the world of medieval culture and within it the reality of statements relating to philosophy and what we could call medieval art. The mechanism of creating short stories from the "Roman Acts" is analyzed, including, firstly, a statement beginning with a sound, opening the way to meaning and things, secondly, the disclosure of the hidden as a creation of an independent reality (science, art, etc.), thirdly, the use of tropes in the course of constructing a multi-valued medieval reality. The author shows that the picture drawn by Neretina well explains the ambiguity of reality, which is important for medieval thinking, however, the explanation of the features of the content of the stories of the "Roman Deeds" is not understood by her on the basis of the picture drawn in the "Preface"; they are interpreted from the point of view of the structure of medieval culture. Then the author discusses the concepts of reality and ambiguity that aroused his interest. At the same time, he already uses his own ideas obtained in the analysis of art. The author explains the differences in the interpretation of the "Roman Acts" by the discrepancy of discourses and views of researchers, which, in his opinion, is completely normal and serves for the benefit of thinking.
Bihormonal Artificial Pancreas With Closed-Loop Glucose Control vs Current Diabetes Care After Total Pancreatectomy
Authors: van Veldhuisen Charlotte L. , Latenstein Anouk E. J. , Blauw Helga , Vlaskamp Lyan B. , Klaassen Michel , Lips Daan J. , Bonsing Bert A. , van der Harst Erwin , Stommel Martijn W. J. , Bruno Marco J. , van Santvoort Hjalmar C. , van Eijck Casper H. J. , van Dieren Susan , Busch Olivier R. , Besselink Marc G. , DeVries J. Hans ,   Dutch Pancreatic Cancer Group, Siegelaar Sarah E. , de Vries Ralph 
Published: September 2022

ImportanceGlucose control in patients after total pancreatectomy is problematic because of the complete absence of α- and β-cells, leading to impaired quality of life. A novel, bihormonal artificial pancreas (BIHAP), using both insulin and glucagon, may improve glucose control, but studies in this setting are lacking.ObjectiveTo assess the efficacy and safety of the BIHAP in patients after total pancreatectomy.Design, Setting, and ParticipantsThis randomized crossover clinical trial compared the fully closed-loop BIHAP with current diabetes care (ie, insulin pump or pen therapy) in 12 adult outpatients after total pancreatectomy. Patients were recruited between August 21 and November 16, 2020. This first-in-patient study began with a feasibility phase in 2 patients. Subsequently, 12 patients were randomly assigned to 7-day treatment with the BIHAP (preceded by a 5-day training period) followed by 7-day treatment with current diabetes care, or the same treatments in reverse order. Statistical analysis was by Wilcoxon signed rank and Mann-Whitney U tests, with significance set at a 2-sided P &amp;lt; .05.Main Outcomes and MeasuresThe primary outcome was the percentage of time spent in euglycemia (70-180 mg/dL [3.9-10 mmol/L]) as assessed by continuous glucose monitoring.ResultsIn total, 12 patients (7 men and 3 women; median [IQR] age, 62.5 [43.1-74.0] years) were randomly assigned, of whom 3 did not complete the BIHAP phase and 1 was replaced. The time spent in euglycemia was significantly higher during treatment with the BIHAP (median, 78.30%; IQR, 71.05%-82.61%) than current diabetes care (median, 57.38%; IQR, 52.38%-81.35%; P = .03). In addition, the time spent in hypoglycemia (&amp;lt;70 mg/dL [3.9 mmol/L]) was lower with the BIHAP (median, 0.00% [IQR, 0.00%-0.07%] vs 1.61% [IQR, 0.80%-3.81%]; P = .004). No serious adverse events occurred.Conclusions and RelevancePatients using the BIHAP after total pancreatectomy experienced an increased percentage of time in euglycemia and a reduced percentage of time in hypoglycemia compared with current diabetes care, without apparent safety risks. Larger randomized trials, including longer periods of treatment and an assessment of quality of life, should confirm these findings.Trial Registrationtrialregister.nl Identifier: NL8871
Quasi‐Continuous Tuning of Carrier Polarity in Monolayered Molybdenum Dichalcogenides through Substitutional Vanadium Doping
Authors: Zhang Lili , Wang Zhe , Zhang Junwei , Chen Bin , Liang Zhaoming , Quan Xiangning , Dai Yudi , Huang Junfeng , Wang Yantao , Liang Shi‐Jun , Long Mingsheng , Si Mingsu , Miao Feng , Peng Yong 
Published: September 2022

AbstractSemiconducting 2D transition metal dichalcogenides (2D TMDs) with tunable electronic properties are a fundamental prerequisite for the development of next generation advanced electronic/optoelectronic devices. However, controllable and quasi‐continuous tuning carrier polarity of monolayered MoS2 ranging from intrinsic n‐type to p‐type via ambipolarity still remains a challenge. Herein, quasi‐continuous tailoring of carrier polarity of monolayered MoS2 through substitutional doping of molybdenum (Mo) with vanadium (V) atoms is presented. Atomic distribution in real space characterized by spherical aberration‐corrected scanning transmission electron microscopy (Cs‐STEM) reveals that the V atoms randomly substitute Mo in monolayered MoS2, and its doping concentration can be tuned in a wide range from 0.7 to ≈10 at.%. Electrical measurements confirm that the carrier polarity of the monolayered MoS2 can be tuned from intrinsic n‐type to p‐type via ambipolarity depending on the V doping degree, consistent with the density functional theory calculations. Moreover, this doping strategy is demonstrated to extend to other monolayered 2D TMDs by using MoSe2 as a model material, owing to a good universality.
Reversibly Controlled Ternary Polar States and Ferroelectric Bias Promoted by Boosting Square‐Tensile‐Strain
Authors: Lee Jun Han , Duong Nguyen Xuan , Jung Min‐Hyoung , Lee Hyun‐Jae , Kim Ahyoung , Yeo Youngki , Kim Junhyung , Kim Gye‐Hyeon , Cho Byeong‐Gwan , Kim Jaegyu , Naqvi Furqan Ul Hassan , Bae Jong‐Seong , Kim Jeehoon , Ahn Chang Won , Kim Young‐Min , Song Tae Kwon , Ko Jae‐Hyeon , Koo Tae‐Yeong , Sohn Changhee , Park Kibog , Yang Chan‐Ho , Yang Sang Mo , Lee Jun Hee , Jeong Hu Young , Kim Tae Heon , Oh Yoon Seok 
Published: September 2022

AbstractInteraction between dipoles often emerges intriguing physical phenomena, such as exchange bias in the magnetic heterostructures and magnetoelectric effect in multiferroics, which lead to advances in multifunctional heterostructures. However, the defect‐dipole tends to be considered the undesired to deteriorate the electronic functionality. Here, deterministic switching between the ferroelectric and the pinched states by exploiting a new substrate of cubic perovskite, BaZrO3 is reported, which boosts the square‐tensile‐strain to BaTiO3 and promotes four‐variants in‐plane spontaneous polarization with oxygen vacancy creation. First‐principles calculations propose a complex of an oxygen vacancy and two Ti3+ ions coins a charge‐neutral defect‐dipole. Cooperative control of the defect‐dipole and the spontaneous polarization reveals ternary in‐plane polar states characterized by biased/pinched hysteresis loops. Furthermore, it is experimentally demonstrated that three electrically controlled polar‐ordering states lead to switchable and nonvolatile dielectric states for application of nondestructive electro‐dielectric memory. This discovery opens a new route to develop functional materials via manipulating defect‐dipoles and offers a novel platform to advance heteroepitaxy beyond the prevalent perovskite substrates.
Dynamic Modulation of Phase Transition by External Strain Engineering in Quasi‐van der Waals Epitaxial VO2 Films on Fluorophlogopite
Authors: Wang Lulu , Shao Zewei , Li Qiang , Liu Jianjun , Yang Chang , Jin Ping , Cao Xun 
Published: September 2022

AbstractUnique metal–insulator transition behaviors of strongly correlated electronic materials, vanadium dioxide (VO2), and their wide potential applications have gained much attention for investigation. In this research, high‐quality epitaxial films of VO2 (020) are directly grown on fluorophlogopite (001) substrates, and the relationship between phase‐transition temperature and external strains is revealed. After verifying the like‐freestanding property and low intrinsic resistance changing of VO2/fluorophlogopite, variable phase‐transition temperatures under different external strains with a tuning rate of 5.37 K per 0.1% strain are obtained. Based on experimental results and theoretical calculation, it is speculated that lattice constant and bandgap between d// and π * are strongly affected by the external strains, which allow for more effective dynamic modulation of phase‐transition process. This research provides a comprehensive understanding of strain engineering on phase‐transition properties and also broadens the possibility of potential applications of certain optoelectronic devices for strain modulation.
Versatile Micro and Nano Patterning Technique for TiO2 and TiN‐Based Sol–Gel Thin Films
Authors: Valour Arnaud , Hochedel Marion , Royon Maxime , Higuita Maria Alejandra Usuga , Crespo‐Monteiro Nicolas , Jourlin Yves 
Published: September 2022

AbstractThis paper describes a tailored and versatile technology route to achieve micro and nanopatterning of both TiO2 and TiN thin films using a direct photo patternable sol–gel approach combined with a rapid thermal annealing and nitridation process. The approach consists in multi‐scale structuring TiO2 using laser direct writing or mask/colloidal lithography on a wide range of substrates including materials and of diverse geometry. These patterned TiO2 layers can subsequently be converted into a micro‐structured metallic TiN layer using a direct rapid thermal nitridation process that results in metallic thin films (TiN). This work demonstrates the versatility of this complete chain of soft chemistry based new process for patterning TiO2 and TiN thin films thereby avoiding expensive processes such as etching and lift‐off, while preserving their diffractive properties and high thermal stability, that is, up to 1000 °C under vacuum. The process is compatible with different kinds of substrates of different shapes and sizes. These results pave the way for developing a cost‐effective and time‐saving approach to different cutting‐edge applications such as metasurfaces, sensors, and applications in the luxury and decoration sector.
Fabrication of Discontinuous Dendritic CH3NH3PbBr3 Perovskite Microdisk Arrays for Microlasers
Authors: Guo Junhan , Tang Yang , Li Longtao , Liu Bin , Li Ling , Meng Fanwen , Qin Liang , Deng Zhenbo , Cui Qiuhong , Lou Zhidong , Hu Yufeng , Teng Feng , Hou Yanbing 
Published: September 2022

AbstractMethylammonium (CH3NH2, MA) lead halide single crystals have attracted attention due to their excellent properties, such as tunable bandgap, high absorption efficiency, long carrier diffusion length, low non‐radiative recombination rate, high gain efficiency, and ultra‐low trap state density. However, excellent methylammonium lead bromine (MAPbBr3) microdisk laser arrays reported at present mainly rely on nanoimprint or inkjet printing technology, which highly depends on the equipment. Herein, an approach to prepare high‐quality MAPbBr3 microdisk arrays is developed in which well‐aligned microdisk arrays grow via partial dissolution and recrystallization of dendrites induced by Marangoni flow in a solution self‐assembly growth process. On the same dendrite, the growth direction of the microdisk crystals is highly consistent, and the crystal size distribution is uniform. Besides, the MAPbBr3 microdisks show excellent laser performance with a low threshold of 43.3 µJ cm−2 and a high Q factor (Q = 2072). The small volume and high‐quality square MAPbBr3 perovskite microdisks have great potential in the application of integrated photoelectric lasers.
Gold‐Catalyzed Bidirectional Access to Planar Heptacyclic Benzobispyrido[1,2‐a]indoles and Benzobispyrrolo[1,2‐a]Quinolines for Materials Science
Authors: Heckershoff Robin , Eberle Lukas , May Garrett , Krämer Petra , Rominger Frank , Rudolph Matthias , Hashmi A. Stephen K. 
Published: September 2022

AbstractOur recently developed gold‐catalyzed synthesis of indolo[1,2‐a]quinolines was successfully expanded towards bidirectional approaches, enabling access to two heptacyclic structural motifs. In the case of benzobispyrido[1,2‐a]indoles, previously inaccessible modifications of the only known representative were made possible. In addition, the synthesis of a new class of nitrogen‐containing heptacycles – namely benzobispyrrolo[1,2‐a]quinolines – was achieved by applying alkynylated benzodipyrrole derivatives as starting materials. All new compounds alongside with their corresponding precursors were fully characterized and their properties were investigated by X‐ray crystallography, photophysical measurements and computational methods. The study revealed important structure‐effect relationships between the solid‐state structures and the observed photophysical properties, e. g. aggregation‐induced emission and solid‐state fluorescence.magnified image
Single Photon Kilohertz Frame Rate Imaging of Neural Activity
Authors: Tian Tian , Yuan Yifang , Mitra Srinjoy , Gyongy Istvan , Nolan Matthew F. 
Published: September 2022

AbstractEstablishing the biological basis of cognition and its disorders will require high precision spatiotemporal measurements of neural activity. Recently developed genetically encoded voltage indicators (GEVIs) report both spiking and subthreshold activity of identified neurons. However, maximally capitalizing on the potential of GEVIs will require imaging at millisecond time scales, which remains challenging with standard camera systems. Here, application of single photon avalanche diode (SPAD) sensors is reported to image neural activity at kilohertz frame rates. SPADs are electronic devices that when activated by a single photon cause an avalanche of electrons and a large electric current. An array of SPAD sensors is used to image individual neurons expressing the GEVI Voltron‐JF525‐HTL. It is shown that subthreshold and spiking activity can be resolved with shot noise limited signals at frame rates of up to 10 kHz. SPAD imaging is able to reveal millisecond scale synchronization of neural activity in an ex vivo seizure model. SPAD sensors may have widespread applications for investigation of millisecond timescale neural dynamics.
Adaptable and Wearable Thermocell Based on Stretchable Hydrogel for Body Heat Harvesting
Authors: Xu Cheng , Sun Yong , Zhang Junji , Xu Wei , Tian He 
Published: September 2022

AbstractThe application of traditional inorganic thermoelectric materials to wearable energy harvesters has been hindered by the rigid bulkiness, while flexible organic conductive polymers have been long troubled by their intrinsic low thermopower. An ideal solution that possesses the merits of the two thermoelectric materials is desperately needed for practical application. Here it is demonstrated that a polyacrylamide (PAAm)‐based ultra‐stretchable hydrogel can be selected as a superior candidate matrix for flexible and stretchable thermocells to adapt to the curved surface of the human body and deformation of the ankle. Fe(ClO4)3/Fe(ClO4)2 is selected as n‐type ion pair for their comparable thermoelectric performance to K3[Fe(CN)6]/K4[Fe(CN)6]. The p‐n pair hydrogel electrolytes show a voltage output of 29 mV and current output of 8.5 Am−2 with an average maximum power density of 0.66 mW K−2 m−2 for each p‐n cell (ΔT = 10 K). By integrating with the graphite paper electrode, a body‐conformal and portable thermocell device, employing the hydrogel electrolytes, is fabricated and reached a voltage output of 0.16 V with 14 pairs of p‐n cells (ΔT = 4.1 K). This commercially‐effective blueprint demonstrates the bright future of hydrogel‐based ionic thermocell in daily wearable scenarios.
Meerwein‐type Bromoarylation with Arylthianthrenium Salts
Authors: Cai Yuan , Ritter Tobias 
Published: September 2022

AbstractHerein, we report a photocatalyzed Meerwein‐type bromoarylation of alkenes with stable arylthianthrenium salts, formed by site‐selective C−H thianthrenation. This protocol can be applied to late‐stage functionalization of a variety of biomolecules that are difficult to access by other aryl coupling reagents. Halogen introduction allows for a variety of follow‐up transformations, affording numerous biologically active skeletons.
Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of Aspartate
Authors: Taresh Ameer B. , Hutton Craig A. 
Published: September 2022

AbstractA site‐specific method for the preparation of N‐glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a AgI‐promoted, site‐specific conversion to N‐glycosylated Asn residues in peptides.