bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the effects of rs1800566 C/T polymorphism of NAD(P)H quinone oxidoreductase 1 gene on cancer risk involves analysis of 43,736 cancer cases and 56,173 controls
Authors: Zhou Hangsheng , Wan Hongyuan , Zhu Lijie , Mi Yuanyuan 
Published: October 2022

ObjectiveA two-electron reductase known as NQO1 [NAD(P)H quinone oxidoreductase 1] is regarded as an excellent anticancer target. Studies have found that rs1800566 polymorphism of NQO1 is linked to different cancers, but their associations remain controversial.MethodsIn the present work, we selected to do a comprehensive meta-analysis to analyze their correlation. We performed searches on PubMed, Embase, Google Scholar, Chinese database, and Web of Science. The results we obtained covered all publications before April 3, 2022.ResultsThere were 176 case-control studies among them, with 56,173 corresponding controls and 43,736 cancer cases. We determined that the NQO1 rs1800566 polymorphism was not related to the cancer risk by calculating 95% confidence intervals and odds ratios. However, stratified genotyping showed that this polymorphism was protective against hepatocellular carcinoma, renal cell carcinoma, and gastric cancer. In addition, on dividing cancer into six systems, the association with gastrointestinal cancer decreased. In the race-based subgroup, a decreasing trend was observed in Asians, while an increasing trend was found among Caucasians, Africans, and mixed populations. The decreased correlation in the hospital-based subgroup was also detected.ConclusionCurrent study shows that rs1800566 polymorphism of NQO1 was linked to cancer susceptibility and maybe as a tumor marker in their development.
Chronic pain through COVID
Authors: Dunham M. , Bacon L. , Cottom S. , McCrone P. , Mehrpouya H. , Spyridonis F. , Thompson T. , Schofield P. 
Published: October 2022

ObjectivesTo identify good practice in the community management of chronic pain, and to understand the perspective of a group of healthcare service users towards the management of chronic pain using technology during the COVID-19 pandemic.MethodsForty-five people, recruited via social media and Pain Association Scotland, participated in three focus groups hosted over Zoom. Focus groups were conducted using semi-structured questions to guide the conversation. Data were analysed using Ritchie / Spencer's Framework Analysis.ResultsThe participants shared observations of their experiences of remotely supported chronic pain services and insights into the potential for future chronic pain care provision. Experiences were in the majority positive with some describing their rapid engagement with technology during the COVID pandemic.ConclusionResults suggest there is strong potential for telehealth to complement and support existing provision of pain management services.
Real-world study of antiresorptive-related osteonecrosis of jaw based on the US food and drug administration adverse event reporting system database
Authors: Peng Jing , Wang Hui , Liu Zhen , Xu Zhen-Liang , Wang Mei-Xia , Chen Qi-Miao , Wu Ming-Li , Ren Xiao-Lei , Liang Qiu-Hua , Liu Fu-Peng , Ban Bo 
Published: October 2022

Objective: This study aims to explore the risk signals of osteonecrosis of the jaw induced by antiresorptive drugs and provide references for the clinical safety application.Method: According to the FDA’s Adverse Event Reporting System (FAERS), from January 2004 to September 2021, we chose “Osteonecrosis of the jaw (10064658)” and “Exposed bone in jaw (10071014)” as preferred terms, “antiresorptive drugs” as the target drugs, and primary suspect drug as the drug role code in the dataset. We evaluated the association between drugs and adverse events by using reporting odds ratio (ROR) based on disproportionality analysis. We took the High-Level Terms (HLT) of MedDRA® as the classification level of indications to calculate ROR to compare the signal difference of ONJ in different indications. In addition, patients with antiresorptive-induced osteonecrosis of the jaw and the time of onset of the condition following different antiresorptive medications were collected for the study.Results: The FAERS contained 18,421 reports relating to jaw osteonecrosis from January 2004 to September 2021. A total of eight antiresorptive agents were included in the analysis. From high to low, the ROR of ONJ induced by antiresorptive agents (regardless of indication) is pamidronate (ROR = 494.8), zoledronic acid (ROR = 431.9), denosumab (ROR = 194.8), alendronate (ROR = 151.2), risedronate (ROR = 140.2), etidronic acid (ROR = 64.5), ibandronate (ROR = 40.8), and romosozumab (ROR = 6.4). HLT ROR values for “metabolic bone disorders” were the lowest for each drug, while HLT ROR values were high for “tumor-related indications,” including breast and nipple neoplasms malignant, plasma cell myelomas, and prostatic neoplasms malignant. The onset time for osteonecrosis of the jaw as median (Q1, Q3), osteoporosis-related indications, and the onset time for ONJ were 730 (368, 1268), 489.5 (236.3, 909.8), 722.5 (314, 1055), 761 (368, 1720), and 153 (50, 346) for zoledronic acid, denosumab, ibandronate, risedronate, and romosozumab, respectively. Cancer-related indications: the onset time for ONJ were 680.5 (255.3, 1283), 488 (245, 851), and 696.5 (347, 1087) for zoledronic acid, denosumab, and pamidronate, respectively.Conclusion: When antiresorptive drugs are used for metastasis, they have the largest risk signal, followed by malignancy, and the smallest is osteoporosis. The onset time of ONJ may not be related to the indications. The onset time of ONJ for BPs was about 2 years, denosumab about 1.3 years, and romosozumab less than 1 year, which may be related to sequential treatment. When used according to the instructions, the risk of ONJ caused by denosumab was higher than that of zoledronic acid, regardless of the indication. Based on these findings, researchers will continue to monitor and identify risk factors.
SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor
Authors: Ma Tingting , Dong Yanli , Huang Lei , Yang Yuanxun , Geng Yan , Fei Fei , Xie Pinhao , Zhao Yu , Lin Hui , Yang Zeyu , Jin Yun , Ju Xitong , Sun Runbin , Li Juan 
Published: October 2022

Purpose: To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SHR2285, the first oral coagulation factor XIa (FXIa) inhibitor developed in China in combination with aspirin, clopidogrel or ticagrelor in healthy subjects.Methods: This study was a single-center, randomized, double-blind, placebo-controlled (only SHR2285) design (NCT04945616). A total of 52 healthy subjects, 29 male and 23 female, were completed in this study. The subjects were divided into three groups: A, B and C, 16 subjects in group A [aspirin + clopidogrel + placebo or SHR2285 200 mg bid (1:3, 4 received placebo and 12 received SHR2285)] 16 subjects in group B [aspirin + clopidogrel + placebo or SHR2285 300 mg bid (1:3, 3 received placebo and 13 received SHR2285)] and 20 subjects in group C (aspirin + ticagrelor + placebo or SHR2285 300 mg bid (2:3, 8 received placebo and 12 received SHR2285)), respectively. All groups were administered orally for six consecutive days. Safety, tolerability, pharmacokinetics and pharmacodynamics parameters were assessed.Results: 1) SHR2285 was well tolerated, and all adverse events were mild. There was no evidence of an increased risk of bleeding. 2) After 6 days of twice-daily administration, SHR2285 could reach a steady state. The mean half-life of SHR2285 in group A, group B and group C was 13.9 h, 14.5 h and 13.8 h, respectively. 3) SHR2285 markedly inhibited FXI activity and prolonged activated partial thromboplastin time (APTT). In group A, group B and group C, the mean maximum inhibition rate of FXI activity was 84.8%, 89.3% and 92.2% and the mean maximum prolongation of APTT was 2.08-fold, 2.36-fold and 2.26-fold, respectively.Conclusion: These data suggest that SHR2285, a potential oral FXIa inhibitor, is expected to become a novel, safe and effective anticoagulant when combined with aspirin, clopidogrel or ticagrelor.
Investigating post-traumatic stress disorder (PTSD) and complex PTSD among people with self-reported depressive symptoms
Authors: Fung Hong Wang , Chien Wai Tong , Lam Stanley Kam Ki , Ross Colin A. 
Published: October 2022

BackgroundTrauma has been increasingly linked to depression. Previous studies have suggested that comorbid post-traumatic stress disorder (PTSD) may be associated with poor outcomes in depression treatment. However, the prevalence and correlates of ICD-11 PTSD and complex PTSD (CPTSD) in people with depression remain unclear.MethodsThis study examined the prevalence and correlates of ICD-11 PTSD and CPTSD in an online convenience sample of 410 adults from 18 different countries/regions who reported clinically significant levels of depressive symptoms (indicated by a Patient Health Questionnaire-9 score ≥10).ResultsAccording to the International Trauma Questionnaire results, 62.68% of participants met the ICD-11 criteria for PTSD/CPTSD (5.6% PTSD, 57.1% CPTSD). Participants with CPTSD reported more types of trauma and higher levels of interpersonal stress than those without PTSD. Participants with CPTSD also reported higher levels of mental health problems, including depressive, dissociative and psychotic symptoms, than those without PTSD. Only disturbances in self-organization (DSO) symptoms but not classical PTSD symptoms had a significant relationship with depressive symptoms, when other major variables (including trauma, interpersonal stress, and comorbid psychotic and dissociative symptoms) were controlled for.ConclusionsTrauma-related symptoms should be regularly screened for in clients who report depressive symptoms. Depressed clients who have comorbid trauma disorders have more trauma and interpersonal stress and exhibit more severe mental health problems. They may require specific trauma-focused interventions in addition to standard depression treatments.
Can internet use change sport participation behavior among residents? Evidence from the 2017 Chinese General Social Survey
Authors: Zhong Hua-mei , Xu Han-bing , Guo En-kai , Li Jing , Wang Zhao-hong 
Published: October 2022

PurposeThe popularization of the internet has promoted the implementation of China's national fitness strategy and created conditions for Chinese residents to participate in sports. The internet is an essential medium for disseminating sports knowledge, and the use of the internet can change sport participation behaviors. Therefore, the internet can be used to popularize sports knowledge and promote the participation of all people in sports and thus improve the health of the entire population. This study attempts to empirically analyse how the use of the internet changes sport participation behavior.MethodUtilizing data from the 2017 China General Social Survey, a probit model, ivprobit model, and bias-corrected non-parametric percentile bootstrap test were used to analyse the impact of internet use on sport participation behavior.ResultsThe empirical results show that internet use significantly increased the probability of participation in sports by Chinese residents. Heterogeneity test results showed that internet use was more effective in promoting sport participation in middle-aged groups, groups of older persons, unmarried groups, and groups with a high school education or above. The mediating effect test results showed that internet use influenced residents' participation in sports by promoting social interaction, leisure and entertainment, and learning and recharging.ConclusionsThe internet has changed participation in sports; specifically, the use of the internet promotes sport participation. Additionally, internet use has a more obvious impact on improving the sport participation behavior of middle-aged, older, unmarried, and middle- and higher-educated individuals. Internet social interaction, internet entertainment and internet learning are effective channels to encourage Chinese residents to participate in sports and improve their health.
Self-medication and its typology in Chinese elderly population: A cross-sectional study
Authors: Qin Shangren , Zhao Junjie , Zhou Mengqiu , Cheng Yenuan , Ding Ye 
Published: October 2022

PurposeThis paper aims to evaluate the prevalence of self-medication and its associated factors among the Chinese elderly. Also, according to whether the elderly communicate with doctors (no matter before or after self-medication), we aimed to categorize self-medication and explore the associated factors.MethodsIt was a cross-sectional study. Data were derived from the 2018 wave of the China Health and Retirement Longitudinal Study (CHARLS). According to whether communicate with doctors or not, self-medication was reclassified as “self-medicate and NOT communicating with a doctor,” and “self-medicate and communicate with a doctor.” A binary logistic regression was used to identify which elderly were more likely to self-medicate, and a multinomial logistic regression was applied to explore the associated influencing factors of self-medication classifications.ResultsA total of 17,445 individuals aged ≥45 years were enrolled. The prevalence of self-medication was 58.60%. Self-medication was strongly associated with sex, education level, pension, self-reported general health status, chronic illness, satisfaction with local medical services, and three province-level socioeconomic welfare variables. About 19.64% of self-medication populations had communicated with a doctor. Higher education level and younger age were significantly associated with a higher probability of “self-medication and communication with a doctor.”ConclusionThe prevalence of self-medication among the Chinese elderly is increasing over the year. Health education on appropriate medication use targeting elder adults with low education levels is highly recommended. The typology of self-medication and its factors are new research entry points and could be meaningful for future studies.
Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients
Authors: Zhang Wen , Chen Qian , Dai Jinghong , Lu Jiaming , Li Jie , Yi Yongxiang , Fu Linqing , Li Xin , Liu Jiani , Liufu Jinlong , Long Cong , Zhang Bing 
Published: October 2022

BackgroundThe coronavirus disease (COVID-19) pandemic, which has been ongoing for more than 2 years, has become one of the largest public health issues. Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is one of the most important interventions to mitigate the COVID-19 pandemic. Our objective is to investigate the relationship between vaccination status and time to seroconversion.MethodsWe conducted a cross-sectional observational study during the SARS-CoV-2 B.1.617.2 outbreak in Jiangsu, China. Participants who infected with the B.1.617.2 variant were enrolled. Cognitive performance, quality of life, emotional state, chest computed tomography (CT) score and seroconversion time were evaluated for each participant. Statistical analyses were performed using one-way ANOVA, univariate and multivariate regression analyses, Pearson correlation, and mediation analysis.ResultsA total of 91 patients were included in the analysis, of whom 37.3, 25.3, and 37.3% were unvaccinated, partially vaccinated, and fully vaccinated, respectively. Quality of life was impaired in 30.7% of patients, especially for mental component summary (MCS) score. Vaccination status, subjective cognitive decline, and depression were risk factors for quality-of-life impairment. The chest CT score mediated the relationship of vaccination status with the MCS score, and the MCS score mediated the relationship of the chest CT score with time to seroconversion.ConclusionFull immunization course with an inactivated vaccine effectively lowered the chest CT score and improved quality of life in hospitalized patients. Vaccination status could influence time to seroconversion by affecting CT score and MCS score indirectly. Our study emphasizes the importance of continuous efforts in encouraging a full vaccination course.
Using mutual information to investigate non-linear correlation between AE index, ULF Pc5 wave activity and electron precipitation
Authors: Hoilijoki Sanni , Kilpua Emilia K. J. , Osmane Adnane , Kalliokoski Milla M. H. , George Harriet , Savola Mikko , Asikainen Timo 
Published: October 2022

In this study, we use mutual information from information theory to investigate non-linear correlation between geomagnetic activity indicated by auroral electrojet (AE) index with both the global ultra low frequency (ULF) Pc5 wave power and medium energy (≥30 keV) electron precipitation at the central outer radiation belt. To investigate the energy and magnetic local time (MLT) dependence of the non-linearity, we calculate the mutual information and Pearson correlation coefficient separately for three different energy ranges (30–100 keV, 100–300 keV and ≥300 keV) and four different MLT sectors (0–6, 6–12, 12–18, 18–24). We compare results from 2 years 2004 and 2007 representing geomagnetically more active and less active years, respectively. The correlation analysis between the AE index and electron precipitation shows a clear MLT and energy dependence in both active and quiet conditions. In the two lowest energy ranges of the medium energy electrons (30–100 keV and 100–300 keV) both non-linear correlation and Pearson correlation indicate strong dependence with the AE index in the dawn sector. The linear dependence indicated by the Pearson correlation coefficient decreases from dawn to dusk while the change in the non-linear correlation is smaller indicating an increase in the non-linearity from dawn to dusk. The non-linearity between the AE index and electron precipitation is larger at all MLT sectors except MLTs 6–12 during geomagnetically more active year when larger amount of the activity is driven by interplanetary coronal mass ejections (ICMEs) compared to lower activity year with high speed stream (HSS) and stream interaction region (SIR) driven activity. These results indicate that the processes leading to electron precipitation become more non-linear in the dusk and during geomagnetically more active times when the activity is driven by ICMEs. The non-linearity between the AE index and global ULF Pc5 activity is relatively low and seems not to be affected by the difference in the geomagnetic activity during the 2 years studied.
Telemedicine use in current urologic oncology clinical practice
Authors: Paesano Nahuel , Carrion Diego M. , Autrán Gomez Ana María 
Published: October 2022

IntroductionIn the last fifteen years, there have been important technological advances in telehealth systems and urology, along with other specialties, has been a pioneer in the successful use of this medical care modality. Due to the COVID-19 pandemic, the use of telemedicine has been rapidly embraced by the urology community around the world. A review of the most relevant and updated articles on telemedicine and telehealth in urology has been carried out with the aim of better understanding how it has been implemented to date, as well as reviewing concepts, current regulations, health policies and recommendations for its implementation.MethodsA narrative review of the current literature published up to April 2022 on the use of telemedicine in urology was performed. From the search results, 42 publications were obtained for analysis.ResultsTelemedicine in urology has been shown to be useful in a variety of clinical scenarios within urological practice, from benign diseases to advanced cancers. This is due to the positive impact on medical consultation times, lower patient mobility costs, less work absenteeism and greater protection for both the patient and the doctor. The main limitations for the use of telemedicine lie in the impossibility of a correct physical examination, which is essential in certain situations, as well as the lack of accessibility to technology in disadvantaged populations and in elderly patients who have not adapted to the use of technology, as well as the lack of development of health policies to establish their implementation in some countries.ConclusionTelemedicine is in full growth. There is much information in the current literature on the successful adoption of telemedicine for patients suffering from urological diseases. While the use and implementation of these new practices has been rapid in the urology community, more work is needed to bring more accessible specialty care to underserved and underdeveloped areas. Health policies must promote its development to reduce costs and increase access.
Impacto das restrições da pandemia de COVID-19 sobre as internações de idosos por doenças cardiovasculares: uma análise local
Authors: Assunção Gilcilene Vieira , Da Costa Marcia Flavia Oliveira , Lucas Junior Carlito José , Oliveira Sandy Freitas , Soares Marilia Junqueira Silva , Novaes Kellen Larissa Maciel , Quinan Paulo Victor Monteiro , Cordeiro Elisa Raquel Vieira Gratão 
Published: October 2022

Tendo completado dois anos, a pandemia do novo-Coronavírus ainda não dá sinal claro de chegar ao seu fim. A emergência de novas variantes fez recentemente subir o número de infectados e de vítimas em todo o mundo. Os indivíduos portadores de comorbidades são os mais afetados, tanto do ponto de vista quantitativo - pela maior morbimortalidade absoluta, quanto na perspectiva qualitativa, pelo maior fardo psicológico que sua condição geralmente significa diante do temor da infecção e suas complicações. Dentre essas comorbidades, figuram entre as mais importantes as doenças cardiovasculares. A pandemia afeta essa população específica de modo peculiar, não só pela maior possibilidade de infecção, necessidade de internação, intubação e morte, mas também pelos desafios que as medidas restritivas globais, para conter o espalhamento do vírus, trouxeram, principalmente no que tange às modificações do estilo de vida. Tais medidas, como o distanciamento e isolamento sociais, implicaram em aumento de sintomas negativos, como estresse, solidão, angústia, medo, bem como redução ou suspensão da prática de atividades físicas e aumento do consumo calórico. Do mesmo modo, alguns pacientes, sobretudo idosos e indivíduos de difícil condição socioeconômica, relataram dificuldade em manter o tratamento medicamentoso e menor quantidade de idas ao médico especialista para acompanhamento. Tais modificações alteram determinantes de saúde e significam aumento global do risco cardiovascular. A pandemia de COVID-19 parece ter interrompido, em várias esferas, o seguimento, o tratamento e as medidas de prevenção às doenças cardiovasculares. O objetivo do presente trabalho é verificar, comparativamente e por meio de dados oficiais, o impacto do período da pandemia sobre o número de internações de idosos por doenças cardiovasculares na cidade de Anápolis (GO). Percebeu-se redução significativa no número de internações por doenças do aparelho circulatório nos anos de 2020 e 2021, tanto para a populaçao em geral (p =0,02), quanto na população idosa (p = 0,01). Mais estudos são necessários para caracterizar melhor essa realidade e sua associação com a pandemia.