bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants
Authors: Lemmens Veerle , Thevelein Bart , Vella Yana , Kankowski Svenja , Leonhard Julia , Mizuno Hideaki , Rocha Susana , Brône Bert , Meier Jochen C. , Hendrix Jelle 
Published: October 2022

AbstractGlycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain treatment and temporal lobe epilepsy. Alternative splicing into K or L variants determines the subcellular fate and function of GlyR-α3, yet it remains to be shown whether its different splice variants can functionally co-assemble, and what the properties of such heteropentamers would be. Here, we subjected GlyR-α3 to a combined fluorescence microscopy and electrophysiology analysis. We employ masked Pearson’s and dual-color spatiotemporal correlation analysis to prove that GlyR-α3 splice variants heteropentamerize, adopting the mobility of the K variant. Fluorescence-based single-subunit counting experiments revealed a variable and concentration ratio dependent hetero-stoichiometry. Via cell-attached single-channel electrophysiology we show that heteropentamers exhibit currents in between those of K and L variants. Our data are compatible with a model where α3 heteropentamerization fine-tunes mobility and activity of GlyR-α3 channels, which is important to understand and tackle α3 related diseases.
Nivolumab versus placebo as adjuvant therapy for resected stage III melanoma: a propensity weighted indirect treatment comparison and number needed to treat analysis for recurrence-free survival and overall survival
Authors: Weber Jeffrey S. , Poretta Tayla , Stwalley Brian D. , Sakkal Leon A. , Du Ella X. , Wang Travis , Chen Yan , Wang Yan , Betts Keith A. , Shoushtari Alexander N. 
Published: October 2022

AbstractBackgroundRecurrence-free survival (RFS) and overall survival (OS) data for adjuvant nivolumab versus placebo (proxy for routine surveillance) in patients with high-risk, resected melanoma are lacking. This post hoc, indirect treatment comparison (ITC) used pooled data from the phase 3 EORTC 18,071 (ipilimumab vs. placebo) and CheckMate 238 (nivolumab vs. ipilimumab) trials to assess RFS and OS with nivolumab versus placebo and the numbers needed to treat (NNT) over 4 years.MethodsPatients with resected stage IIIB-C cutaneous melanoma (American Joint Committee on Cancer seventh edition) were included. Inverse probability treatment weighting (IPTW) was used to balance baseline characteristics. RFS NNTs were calculated for nivolumab versus ipilimumab and placebo. OS NNTs were calculated for nivolumab versus placebo. To adjust for different post-recurrence treatments, the difference in post-recurrence survival between the two ipilimumab arms was added to OS of the placebo arm.ResultsThis ITC included 278, 643, and 365 patients treated with nivolumab, ipilimumab, and placebo, respectively. Following IPTW, nivolumab was associated with improved RFS versus placebo (hazard ratio [HR]: 0.49; 95% confidence interval [CI] 0.39–0.61) and ipilimumab (HR: 0.69; 95% CI 0.56–0.85). RFS NNT was 4.2 for nivolumab versus placebo and 8.9 for nivolumab versus ipilimumab. After post-recurrence survival adjustment, weighted 4-year OS rates were 75.8% for nivolumab and 64.1% for placebo; OS NNT for nivolumab versus placebo was 8.5.ConclusionsIn patients with resected stage IIIB-C cutaneous melanoma in this ITC, nivolumab improved RFS versus placebo and ipilimumab, and OS versus placebo after post-recurrence survival adjustment.
Controlling Nutritional Status Score Serves as a Prognosticator in Esophageal Squamous Cell Carcinoma: Optimal Timing of Evaluation of Patients Undergoing Neoadjuvant Treatment
Authors: Nonogaki Ikue , Kanda Mitsuro , Shimizu Dai , Inokawa Yoshikuni , Hattori Norifumi , Hayashi Masamichi , Tanaka Chie , Koike Masahiko , Nakayama Goro , Kodera Yasuhiro 
Published: October 2022

AbstractBackgroundUsefulness of various nutritional indices for management of patients with esophageal squamous cell carcinoma (ESCC) has been reported. Although Controlling Nutritional Status (CONUT) score is among promising indices to predict outcome, the optimal timing for its measurement during the perioperative period remains unknown. Here the prognostic value of the CONUT score was assessed among patients with ESCC.MethodsWe analyzed 464 patients who underwent subtotal esophagectomy of ESCC, of which 276 patients were treated with neoadjuvant treatment (NAT). The significance of the associations between candidate parameters including the CONUT score and postoperative prognosis were evaluated.ResultAmong the 25 candidate predictors, the preoperative CONUT score had the highest correlation with overall survival (OS) after surgery. Patients were categorized as follows: normal, mild, and moderate or severe, on the basis of the preoperative CONUT score. OS was significantly shortened as the CONUT score worsened. Multivariable analysis revealed that the CONUT scores of the subgroups mild (Hazard ratio [HR] 1.69) and moderate or severe (HR 2.18) were independent predictors of poor prognosis for OS. Furthermore, in an analysis limited to patients who underwent NAT, OS was significantly shortened as the preoperative CONUT score worsened. On the contrary, there was no significant difference in RFS among patient groups stratified by the CONUT score determined before NAT.ConclusionsOur study indicates that the preoperative CONUT score serves as a prognosticator in resectable ESCC. The preoperative CONUT value was more useful than that before NAT in patients administered NAT.
Deforestation for agriculture increases microbial carbon use efficiency in subarctic soils
Authors: Schroeder Julia , Peplau Tino , Pennekamp Frank , Gregorich Edward , Tebbe Christoph C. , Poeplau Christopher 
Published: October 2022

AbstractAgriculture is likely to expand poleward with climate change, encouraging deforestation for agriculture in subarctic regions, which alters soil physical, chemical and biological properties and potentially affects microbial metabolic efficiency. Deciphering how and by which mechanisms land-use change affects microbial carbon use efficiency (CUE) will enable the development of mitigation strategies to alleviate C losses. We assessed CUE using 18O-labelled water in a paired-plot approach on soils collected from 19 farms across the subarctic region of Yukon, Canada, comprising 14 pairs of forest-to-grassland conversion and 15 pairs of forest-to-cropland conversion. Microbial CUE significantly increased following conversion to grassland and cropland. Land-use conversion resulted in a lower estimated abundance of fungi, while the archaeal abundance increased. Interestingly, structural equation modelling revealed that increases in CUE were mediated by a rise in soil pH and a decrease in soil C:N ratio rather than by shifts in microbial community composition, i.e. the ratio of fungi, bacteria and archaea. Our findings indicate a direct control of abiotic factors on microbial CUE via improved nutrient availability and facilitated conditions for microbial growth. Overall, this implies that to a certain extent CUE can be managed to achieve a more efficient build-up of stabilised soil organic C (SOC), as reflected in increased mineral-associated organic C under agricultural land use. These insights may also help constrain SOC models that generally struggle to predict the effects of deforestation, something that is likely to take place more frequently in the subarctic.
Quantifying the impact of heat on human physical work capacity; part IV: interactions between work duration and heat stress severity
Authors: Smallcombe James W. , Foster Josh , Hodder Simon G. , Jay Ollie , Flouris Andreas D. , Havenith George 
Published: October 2022

Abstract
High workplace temperatures negatively impact physical work capacity (PWC). Although PWC loss models with heat based on 1-h exposures are available, it is unclear if further adjustments are required to accommodate repeated work/rest cycles over the course of a full work shift. Therefore, we examined the impact of heat stress exposure on human PWC during a simulated work shift consisting of six 1-h work-rest cycles. Nine healthy males completed six 50-min work bouts, separated by 10-min rest intervals and an extended lunch break, on four separate occasions: once in a cool environment (15 °C/50% RH) and in three different air temperature and relative humidity combinations (moderate, 35 °C/50% RH; hot, 40 °C/50% RH; and very hot, 40 °C/70%). To mimic moderate to heavy workload, work was performed on a treadmill at a fixed heart rate of 130 beats·min−1. During each work bout, PWC was quantified as the kilojoules expended above resting levels. Over the shift, work output per cycle decreased, even in the cool climate, with the biggest decrement after the lunch break and meal consumption. Expressing PWC relative to that achieved in the cool environment for the same work duration, there was an additional 5(± 4)%, 7(± 6)%, and 16(± 7)% decrease in PWC when work was performed across a full work shift for the moderate, hot, and very hot condition respectively, compared with 1-h projections. Empirical models to predict PWC based on the level of heat stress (Wet-Bulb Globe Temperature, Universal Thermal Climate Index, Psychrometric Wet-Bulb Temperature, Humidex, and Heat Index) and the number of work cycles performed are presented.
Scientific paper recommendation systems: a literature review of recent publications
Authors: Kreutz Christin Katharina , Schenkel Ralf 
Published: October 2022

AbstractScientific writing builds upon already published papers. Manual identification of publications to read, cite or consider as related papers relies on a researcher’s ability to identify fitting keywords or initial papers from which a literature search can be started. The rapidly increasing amount of papers has called for automatic measures to find the desired relevant publications, so-called paper recommendation systems. As the number of publications increases so does the amount of paper recommendation systems. Former literature reviews focused on discussing the general landscape of approaches throughout the years and highlight the main directions. We refrain from this perspective, instead we only consider a comparatively small time frame but analyse it fully. In this literature review we discuss used methods, datasets, evaluations and open challenges encountered in all works first released between January 2019 and October 2021. The goal of this survey is to provide a comprehensive and complete overview of current paper recommendation systems.
Automated repair for timed systems
Authors: Kölbl Martin , Leue Stefan , Wies Thomas 
Published: October 2022

AbstractWe present algorithms and techniques for the repair of timed system models, given as networks of timed automata (NTA). The repair is based on an analysis of timed diagnostic traces (TDTs) that are computed by real-time model checking tools, such as UPPAAL, when they detect the violation of a timed safety property. We present an encoding of TDTs in linear real arithmetic and use the MaxSMT capabilities of the SMT solver Z3 to suggest a minimal number of possible syntactic repairs of the analyzed model. The suggested repairs include modified values for clock bounds in location invariants and transition guards, adding or removing clock resets, etc. We then present an admissibility criterion, called functional equivalence, which ensures that the proposed repair preserves the functional behavior of the considered NTA. We discuss a proof-of-concept tool called TarTar that we have developed, implementing the repair and admissibility analysis, and give insights into its design and architecture. We evaluate the proposed repair technique on faulty mutations generated from a diverse suite of case studies taken from the literature. We show that TarTar can admissibly repair for 69–$$88\%$$

88
%

of the seeded errors in the considered system models.
Nurse rostering with fatigue modelling
Authors: Klyve Kjartan Kastet , Senthooran Ilankaikone , Wallace Mark 
Published: October 2022

AbstractWe use a real Nurse Rostering Problem and a validated model of human sleep to formulate the Nurse Rostering Problem with Fatigue. The fatigue modelling includes individual biologies, thus enabling personalised schedules for every nurse. We create an approximation of the sleep model in the form of a look-up table, enabling its incorporation into nurse rostering. The problem is solved using an algorithm that combines Mixed-Integer Programming and Constraint Programming with a Large Neighbourhood Search. A post-processing algorithm deals with errors, to produce feasible rosters minimising global fatigue. The results demonstrate the realism of protecting nurses from highly fatiguing schedules and ensuring the alertness of staff. We further demonstrate how minimally increased staffing levels enable lower fatigue, and find evidence to suggest biological complementarity among staff can be used to reduce fatigue. We also demonstrate how tailoring shifts to nurses’ biology reduces the overall fatigue of the team, which means managers must grapple with the issue of fairness in rostering.
Thermophysical Properties Mapping of Composites by Lock-in Thermography: Applications on Carbon Fiber Reinforced Plastics
Authors: Alasli Abdulkareem , Fujita Ryohei , Nagano Hosei 
Published: October 2022

AbstractWe propose a versatile method for measuring the thermophysical properties of composites by means of lock-in thermography (LIT) technique. The method is based on analyzing the thermal response distribution induced by periodic laser heating, which enables simultaneous high-spatial-resolution mapping of the effective out-of-plane thermal diffusivity, thermal conductivity, and volumetric heat capacity over the surface of the material. We validate the method using a reference material and demonstrate its capability in visualizing the effective properties of laminated carbon fiber reinforced plastic and carbon fiber reinforced thermoplastic with discontinuous fibers. The results showed that the LIT-based approach has high reproducibility and sensitivity, which allows observing the effect of fiber orientations on the effective properties. The proposed method will be useful for thermal research in composites, defect detection, and for investigating component geometric arrangement effects on the thermophysical properties.
Energy Loss After Daily Role Stress and Work Incivility: Caring for Oneself with Emotional Wellness
Authors: Garrosa Eva , Blanco-Donoso Luis Manuel , Moreno-Jiménez Jennifer E. , McGrath Eugenia , Cooper-Thomas Helena D. , Ladstätter Felix 
Published: October 2022

AbstractThe present study seeks to build on burnout research by examining daily fluctuations of role stress and work incivility, and their impact on employees’ energy loss. Optimism and recovery (i.e., psychological detachment and relaxation), two mechanisms that allow workers’ self-care and self-defence from these toxic conditions when faced by these job stressors, were included. In a daily study, 117 service sector workers completed surveys three times a day, over a period of one working week. Hierarchical linear modeling revealed work incivility as predictor of daily emotional exhaustion. Optimism and recovery play different roles in protecting workers from daily energy loss. Daily optimism increased employees’energy and decreased emotional exhaustion and negative affect at night. It also moderated the relationship between work incivility and positive affect at night. The results on psychological detachment supported the stressor-detachment model (Sonnentag, 2010), in which psychological detachment from work during nonworking time is not only a direct predictor of increased energy, but could similarly buffer the negative impact of role stress and work incivility. Relaxation basically showed main effects in predicting emotional exhaustion (inversely) and positive affect (directly). Our findings suggest two main implications: (1) the necessity for implemention of workplace policies to prevent role stress and work incivility in reducing daily loss of energy. (2) Training workers in self-care programmes focusing on optimism and recovery can provide early steps toward organizational change and employee daily well-being.
Agent-based models of human response to natural hazards: systematic review of tsunami evacuation
Authors: Mls Karel , Kořínek Milan , Štekerová Kamila , Tučník Petr , Bureš Vladimír , Čech Pavel , Husáková Martina , Mikulecký Peter , Nacházel Tomáš , Ponce Daniela , Zanker Marek , Babič František , Triantafyllou Ioanna 
Published: October 2022

AbstractThis systematic review provides a comprehensive overview of tsunami evacuation models. The review covers scientific studies from the last decade (2012–2021) and is explicitly focused on models using an agent-based approach. The PRISMA methodology was used to analyze 171 selected papers, resulting in over 53 studies included in the detailed full-text analysis. This review is divided into two main parts: (1) a descriptive analysis of the presented models (focused on the modeling tools, validation, and software platform used, etc.), and (2) model analysis (e.g., model purpose, types of agents, input and output data, and modeled area). Special attention was given to the features of these models specifically associated with an agent-based approach. The results lead to the conclusion that the research domain of agent-based tsunami evacuation models is quite narrow and specialized, with a high degree of variability in the model attributes and properties. At the same time, the application of agent-specific methodologies, protocols, organizational paradigms, or standards is sparse.
Split Hamiltonian Monte Carlo revisited
Authors: Casas Fernando , Sanz-Serna Jesús María , Shaw Luke 
Published: October 2022

AbstractWe study Hamiltonian Monte Carlo (HMC) samplers based on splitting the Hamiltonian H as $$H_0(\theta ,p)+U_1(\theta )$$

H
0

(
θ
,
p
)

+

U
1

(
θ
)

, where $$H_0$$

H
0

is quadratic and $$U_1$$

U
1

small. We show that, in general, such samplers suffer from stepsize stability restrictions similar to those of algorithms based on the standard leapfrog integrator. The restrictions may be circumvented by preconditioning the dynamics. Numerical experiments show that, when the $$H_0(\theta ,p)+U_1(\theta )$$

H
0

(
θ
,
p
)

+

U
1

(
θ
)

splitting is combined with preconditioning, it is possible to construct samplers far more efficient than standard leapfrog HMC.
Preoperative endogenous testosterone density predicts disease progression from localized impalpable prostate cancer presenting with PSA levels elevated up to 10 ng/mL
Authors: Porcaro Antonio Benito , Bianchi Alberto , Mazzucato Giovanni , Gallina Sebastian , Serafin Emanuele , Tafuri Alessandro , Cerrato Clara , Panunzio Andrea , Vidiri Stefano , D’Aietti Damiano , Orlando Rossella , Brusa Davide , Brunelli Matteo , Siracusano Salvatore , Cerruto Maria Angela , Antonelli Alessandro 
Published: October 2022

Abstract
Objective
To investigate endogenous testosterone density (ETD) predicting disease progression from clinically localized impalpable prostate cancer (PCa) presenting with prostate-specific antigen (PSA) levels elevated up to 10 ng/mL and treated with radical prostatectomy.

Materials and methods
In a period ranging from November 2014 to December 2019, 805 consecutive PCa patients who were not under androgen blockade had endogenous testosterone (ET, ng/dL) measured before surgery. ETD was evaluated as the ratio of ET on prostate volume (PV). Unfavorable disease was defined as including ISUP ≥ 3 and/or seminal vesicle invasion in the surgical specimen. The risk of disease progression was evaluated by statistical methods.

Results
Overall, the study selected 433 patients, of whom 353 (81.5%) had available follow-up. Unfavorable disease occurred in 46.7% of cases and was predicted by tumor quantitation features that were positively associated with ETD. Disease progression, which occurred for 46 (13%) cases, was independently predicted only by ETD (hazard ratio, HR = 1.037; 95% CI 1.004–1.072; p = 0.030) after adjusting for unfavorable disease. According to a multivariate model, ETD above the third quartile was confirmed to be an independent predictor for PCa progression (HR = 2.479; 95% CI 1.355–4.534; p = 0.003) after adjusting for unfavorable disease. The same ETD measurements, ET mean levels were significantly lower in progressing cancers.

Conclusions
In this particular subset of patients, increased ETD with low ET levels, indicating androgen independence, resulted in a more aggressive disease with poorer prognosis.
Comparing cryptocurrencies and gold - a system-GARCH-approach
Authors: Klose Jens 
Published: October 2022

AbstractThis article investigates similarities and differences between gold and four cryptocurrencies (Bitcoin, Ethereum, Bitcoin Cash and Litecoin) with respect to four determinants. To do so, we estimate a system-GARCH-in-mean for the period starting 7/18/2014 at earliest until 7/12/2021. We find that, first, liquidity premia are almost always insignificant for both gold and cryptocurrencies. Second, volatility premia exist in either gold and cryptocurrencies. Third, the response of cryptocurrencies to exchange rate changes is more pronounced than for gold at least if developing countries are included. Fourth, gold exhibits a safe haven status, while cryptocurrencies do not. So according to our results those cannot be seen as a store of value but rather should be seen as speculative assets.
Detailed design for additive manufacturing and post processing of generatively designed high tibial osteotomy fixation plates
Authors: Kanagalingam Sanjeevan , Dalton Chris , Champneys Peter , Boutefnouchet Tarek , Fernandez-Vicente Miguel , Shepherd Duncan E. T. , Wimpenny David , Thomas-Seale Lauren E. J. 
Published: October 2022

AbstractIntegration of advanced technologies have revitalised treatment methods in the current clinical practice. In orthopaedic surgery, patient-specific implants have leveraged the design freedom offered by additive manufacturing (AM) exploiting the capabilities within powder bed fusion processes. Furthermore, generative design (GD), a design exploration tool based on the artificial intelligence, can integrate manufacturing constraints in the concept development phase, consequently bridging the gap between AM design and manufacturing. However, the reproducibility of implant prototypes are severely constrained due to uncomprehensive information on manufacturing and post processing techniques in the detailed design phase. This paper explores the manufacturing feasibility of novel GD concept plate designs for High Tibial Osteotomy (HTO), a joint preserving surgery for a patient diagnosed with osteoarthritis in the knee. A design for AM (DfAM) workflow for a generatively designed HTO plate is presented, including; detailed DfAM of GD concept designs, fabrication of plate prototypes using electron beam powder bed fusion (PBF-EB) of medical grade Ti-6Al-4 V, post processing and inspection. The study established PBF-EB as a suitable manufacturing method for the highly complex GD plate fixations, through evaluating the impact of manufacturing and post processing on the surface finish and geometrical precision of the plate design features.