bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowing how you see me: Exploring meta‐accuracy of personality, emotions and values and their links with relationship well‐being among young adults
Authors: Tissera Hasagani , Lydon John E. 
Published: January 2022

AbstractIntroductionDo people (i.e., metaperceivers) know their romantic partners’ (i.e., perceivers’) impressions, displaying meta‐accuracy? Is it related to relationship well‐being? We explored two components of meta‐accuracy: (1) positive meta‐accuracy (i.e., knowing the perceiver’s positive impressions of the metaperceiver), and (2) distinctive meta‐accuracy (i.e., knowing the perceiver’s unique impressions of the metaperceiver). First, we compared baseline levels of each component across three domains (personality, emotions, values), and, second, examined and compared their links with relationship well‐being.MethodA sample of 205 romantic couples were recruited. The Social Accuracy Model was adapted for analyses.ResultsMetaperceivers displayed both positive and distinctive meta‐accuracy across all domains, and displayed greater positive emotion meta‐accuracy and distinctive personality meta‐accuracy compared to the other domains. Positive meta‐accuracy, in general, was related to metaperceivers’ relationship well‐being and distinctive meta‐accuracy, in general, was related to relationship well‐being for metaperceivers and perceivers. Further, positive personality meta‐accuracy was associated with relationship well‐being for metaperceivers, and positive emotion meta‐accuracy was associated with relationship well‐being for metaperceivers and perceivers.ConclusionOverall, the present research broadens the meta‐accuracy literature by expanding it to a novel domain (values) and highlighting the relative contributions of domains that has been previously explored in isolation (personality and emotions).
Growing Memories: Coaching mothers in elaborative reminiscing with toddlers benefits adolescents' turning‐point narratives and wellbeing
Authors: Mitchell Claire , Reese Elaine 
Published: January 2022

AbstractIntroductionParental elaborative reminiscing supports young children's autobiographical memory, narrative, and socioemotional skills.ObjectiveThis study is an adolescent follow‐up of a reminiscing intervention in which 115 primary‐caregiver mothers of toddlers were randomly assigned to a control group (n = 59) or to receive training in elaborative reminiscing (n = 56) for the next year.MethodAt age 15, 93 of the now‐adolescents (81%) were invited to narrate a turning point in their lives and to report on their personality traits and well‐being. Turning‐point narratives were coded for causal coherence (connections between past events and present self) and thematic coherence (elaboration and resolutions).ResultsAdolescents whose mothers were in the intervention group told more causally coherent turning‐point narratives and reported fewer emotional problems than control participants, covarying for baseline measures and personality traits.ConclusionMaternal elaborative reminiscing in early childhood appears to have long‐term benefits for adolescents' causal coherence in turning‐point narratives and well‐being.
Old age or dependence: Which social insurance?
Authors: Nishimura Yukihiro , Pestieau Pierre 
Published: January 2022

AbstractIn recent decades, there has been an increase in life expectancy and a rapid increase of the very senior dependency ratio in developed countries. In this context, we examine the optimal levels of public pensions and public long‐term care (LTC) insurance. According to the most reasonable estimates of correlations among individual incomes, risks of mortality and dependency, we show that it is always desirable for a utilitarian social planner to have a balanced budget increase in LTC benefits at the expense of public pension benefits, until the cost of LTC is fully covered. This is true with or without liquidity constraints. For a Rawlsian planner, the balance between the two schemes depends on a comparison of the ratio of the survival probability to the dependence risk of the poor with its population average.
Legal barriers to the implementation of digital industry (Industry 4.0) components and ways to overcome them
Authors: Gromova Elizaveta A. , Koneva Natalia S. , Titova Elena V. 
Published: January 2022

AbstractThe creation and implementation of competitive digital technologies is an important task for every state striving for global political and economic leadership. Today, the issue of creating and implementing components of the digital industry (Industry 4.0), the use of which can significantly affect the development of industrial production of the state, is especially relevant. At the same time, solving this problem is extremely difficult due to the need to overcome some barriers that hinder the development of the digital industry (Industry 4.0). Among these, legal barriers pose a major problem. The purpose of the article was to identify the key legal barriers to the implementation of the components of the digital industry (Industry 4.0) and choose the best ways to overcome them. The methods that formed the basis of the study were a comparative legal analysis of the current domestic and foreign legislation, as well as scientific literature on the digital industry, its components, barriers that hinder their development and tools to overcome them, as well as a systemic method and method of legal modeling. As a result of the study, the authors identified the key legal barriers to creating and implementing components of the digital industry (Industry 4.0). To overcome them, the authors propose to use legal instruments, the complex application of which will contribute to the improvement of the current legislation in the field of digital technologies creation, the attraction of investments in their creation and implementation, as well as ensuring the digital sovereignty of the country.
Men suffering from category III chronic prostatitis may benefit from N‐acetylcysteine as an adjunct to alpha‐blockers
Authors: Yaryari Amir‐mohammad , Mousavibahar Seyed Habibollah , Amirhassani Shahriar , Bagheri Maryam , Mohammadi Younes , Mehrpooya Maryam 
Published: January 2022

AbstractObjectiveWe designed this study to investigate the potential use of N‐acetylcysteine (NAC) as an adjunct to alpha‐blockers in the treatment of category III chronic prostatitis (CP).MethodsSixty‐three men with category III CP with a National Institutes of Health Chronic Prostatitis Symptom Index (NIH‐CPSI) total score of 15 or more were randomized to either the NAC treatment group or the placebo treatment group. Besides tamsulosin at a dose of 0.4 mg once daily, participants based on their allocation group received NAC or placebo at a dose of 600 mg twice daily for 12 weeks. The efficacy of the medications was assessed by measuring changes in the NIH‐CPSI total score and its subscales, including pain, urinary symptoms, and quality of life.ResultsBased on the general linear model analysis of the data, over the 12‐week treatment, NAC+tamsulosin was statistically superior to placebo+tamsulosin in reducing the total NIH‐CPSI score, pain subscore, and quality‐of‐life subscore (P value <.001). Further, after 12 weeks, more patients in the NAC+tamsulosin group than in the placebo+tamsulosin group met the responder criterion, defined as a decrease of at least 6 points in the NIH‐CPSI total score (65.6% vs 29.0%). A more favorable outcome was also noted in the NAC+tamsulosin group regarding the number of patients reporting moderate or marked improvement in symptoms (62.5% vs 25.80%). No significant difference was seen between the groups concerning changes in urinary symptoms.ConclusionsOur study provided clinical evidence that men with category III CP might benefit from NAC treatment. Further studies are needed for the validation of these findings.
Origin and expansion of the world’s most widespread pinniped: Range‐wide population genomics of the harbour seal (Phoca vitulina)
Authors: Liu Xiaodong , Rønhøj Schjøtt Suzanne , Granquist Sandra M. , Rosing‐Asvid Aqqalu , Dietz Rune , Teilmann Jonas , Galatius Anders , Cammen Kristina , O’Corry‐Crowe Greg , Harding Karin , Härkönen Tero , Hall Ailsa , Carroll Emma L. , Kobayashi Yumi , Hammill Mike , Stenson Garry , Kirstine Frie Anne , Lydersen Christian , Kovacs Kit M. , Andersen Liselotte W. , Hoffman Joseph I. , Goodman Simon J. , Vieira Filipe G. , Heller Rasmus , Moltke Ida , Tange Olsen Morten 
Published: January 2022

AbstractThe harbour seal (Phoca vitulina) is the most widely distributed pinniped, occupying a wide variety of habitats and climatic zones across the Northern Hemisphere. Intriguingly, the harbour seal is also one of the most philopatric seals, raising questions as to how it colonized its current range. To shed light on the origin, remarkable range expansion, population structure and genetic diversity of this species, we used genotyping‐by‐sequencing to analyse ~13,500 biallelic single nucleotide polymorphisms from 286 individuals sampled from 22 localities across the species’ range. Our results point to a Northeast Pacific origin of the harbour seal, colonization of the North Atlantic via the Canadian Arctic, and subsequent stepping‐stone range expansions across the North Atlantic from North America to Europe, accompanied by a successive loss of genetic diversity. Our analyses further revealed a deep divergence between modern North Pacific and North Atlantic harbour seals, with finer‐scale genetic structure at regional and local scales consistent with strong philopatry. The study provides new insights into the harbour seal's remarkable ability to colonize and adapt to a wide range of habitats. Furthermore, it has implications for current harbour seal subspecies delineations and highlights the need for international and national red lists and management plans to ensure the protection of genetically and demographically isolated populations.
The complex Tup1‐Cyc8 bridges transcription factor ClrB and putative histone methyltransferase LaeA to activate the expression of cellulolytic genes
Authors: Zhang Xiujun , Hu Yueyan , Liu Guodong , Liu Meng , Li Zhonghai , Zhao Jian , Song Xin , Zhong Yaohua , Qu Yinbo , Wang Lushan , Qin Yuqi 
Published: January 2022

AbstractThe degradation of lignocellulosic biomass by cellulolytic enzymes is involved in the global carbon cycle. The hydrolysis of lignocellulosic biomass into fermentable sugars is potential as an excellent industrial resource to produce a variety of chemical products. The production of cellulolytic enzymes is regulated mainly at the transcriptional level in filamentous fungi. Transcription factor ClrB and the putative histone methyltransferase LaeA, are both necessary for the expression of cellulolytic genes. However, the mechanism by which transcription factors and methyltransferase coordinately regulate cellulolytic genes is still unknown. Here, we reveal a transcriptional regulatory mechanism involving Penicillium oxalicum transcription factor ClrB (PoClrB), complex Tup1‐Cyc8, and putative histone methyltransferase LaeA (PoLaeA). As the transcription factor, PoClrB binds the targeted promoters of cellulolytic genes, recruits PoTup1‐Cyc8 complex via direct interaction with PoTup1. PoTup1 interacts with PoCyc8 to form the coactivator complex PoTup1‐Cyc8. Then, PoTup1 recruits putative histone methyltransferase PoLaeA to modify the chromatin structure of the upstream region of cellulolytic genes, thereby facilitating the binding of transcription machinery to activating the corresponding cellulolytic gene expression. Our results contribute to a better understanding of complex transcriptional regulation mechanisms of cellulolytic genes and will be valuable for lignocellulosic biorefining.
The effect of age, sex, and resource abundance on patterns of rake markings in resident killer whales (Orcinus orca)
Authors: Grimes Charli , Brent Lauren J. N. , Weiss Michael N. , Franks Daniel W. , Balcomb Kenneth C. , Ellifrit David K. , Ellis Samuel , Croft Darren P. 
Published: January 2022

AbstractFluctuations in aggressive behavior of group‐living species can reflect social conflict and competition for resources faced by individuals throughout their lifespan and can negatively impact survival and reproduction. In marine mammals, where social interactions are difficult to observe, tooth rake marks can be used as an indicator of received aggression. Using 38 years of photographic data, we quantified the occurrence of tooth rake marks on wild resident killer whales (Orcinus orca), examining the effects of age, sex, and prey abundance on rake density. Our analysis revealed sex and age effects, with males exhibiting higher rake density than females and rake density declining significantly with age. Contrary to predictions, we observed an increase in rake density across the population as the abundance of their primary food resource, Chinook salmon (Oncorhynchus tshawytscha), increased. These results provide indirect evidence of fluctuations in received aggression from conspecifics across the lifespan of an individual, possibly reflecting changes in patterns of social conflict which may be mediated by resource abundance. Our findings highlight the need for further research to examine the fitness consequences of aggression in killer whales and to understand the proximate mechanisms by which resource abundance influences rates of aggression in the population.
Topical sertaconazole during pregnancy and risk of adverse pregnancy outcome and major congenital anomalies: Comparative study in the EFEMERIS database
Authors: Araujo Mélanie , Hurault‐Delarue Caroline , Sommet Agnès , Damase‐Michel Christine , Lacroix Isabelle 
Published: January 2022

AbstractIntroductionTopical sertaconazole is indicated in the treatment of vaginal or mucocutaneous fungal infections due to Candida and dermatophytosis. To our knowledge, there is no data available in the literature on the potential effects of sertaconazole during pregnancy. The aim of this study was to evaluate the potential risks of topical sertaconazole use during pregnancy for the foetus and pregnancy.Materials and methodsThe EFEMERIS database was used, which contained medications prescribed and dispensed to pregnant women in the Haute‐Garonne region whose pregnancy ended between July 2004 and December 2018. We compared pregnant women exposed to sertaconazole at least once during pregnancy to unexposed. Crude and adjusted odds ratios (OR) of major congenital anomalies and small gestational age at birth were estimated using logistic regression models. For other outcomes, hazard ratios (HR) were estimated by Cox regression models.ResultsThe study included 16,222 pregnant women (15.0%) who were given sertaconazole and 91,976 who were not. Exposure to sertaconazole during pregnancy was not associated with increased risks of any of the investigated outcomes, including natural pregnancy termination (HRa = 0.92 [0.78–1.08]), preterm birth (HRa = 1.06 [0.95–1.17]) and small for gestational age at birth (ORa = 0.78 [0.66–0.92]). No association between risk of major congenital anomalies overall and maternal exposure to sertaconazole during the first trimester was observed (ORa = 1.01 [0.84–1.21]).DiscussionThis is the first study involving a large number of pregnant women to assess the potential risks of sertaconazole during pregnancy. This study does not indicate an increased risk of adverse pregnancy outcome and major congenital anomalies from exposure to topical sertaconazole.
A rare cause of idiopathic right outflow tract premature ventricular contraction: Type‐4 renal tubular acidosis
Authors: Atici Adem , Tatlisu Mustafa Adem , Baycan Omer Faruk , Yılmaz Yusuf , Caliskan Mustafa 
Published: January 2022

AbstractThe premature ventricular contractions (PVCs) have usually good prognosis in patients without structural heart disease. In case of left ventricular ejection fraction depression or symptoms, antiarrhythmic drugs or cardiac ablations could be an option for management. We present a case of a patient with high burden of PVC admitted for cardiac ablation. Preoperative assessment revealed hyperkalemia and metabolic acidosis which ended up with type‐4 renal tubular acidosis (RTA). Its rare cause and management may draw attention to the possibility of type ‐4 RTA as the cause of the PVC, and hyperkalemia.
Plant elicitor peptide signalling confers rice resistance to piercing‐sucking insect herbivores and pathogens
Authors: Shen Wenzhong , Zhang Xue , Liu Jiuer , Tao Kehan , Li Chong , Xiao Shi , Zhang Wenqing , Li Jian‐Feng 
Published: January 2022

SummaryRice is a staple food crop worldwide, and its production is severely threatened by phloem‐feeding insect herbivores, particularly the brown planthopper (BPH, Nilaparvata lugens), and destructive pathogens. Despite the identification of many BPH resistance genes, the molecular basis of rice resistance to BPH remains largely unclear. Here, we report that the plant elicitor peptide (Pep) signalling confers rice resistance to BPH. Both rice PEP RECEPTORs (PEPRs) and PRECURSORs of PEP (PROPEPs), particularly OsPROPEP3, were transcriptionally induced in leaf sheaths upon BPH infestation. Knockout of OsPEPRs impaired rice resistance to BPH, whereas exogenous application of OsPep3 improved the resistance. Hormone measurement and co‐profiling of transcriptomics and metabolomics in OsPep3‐treated rice leaf sheaths suggested potential contributions of jasmonic acid biosynthesis, lipid metabolism and phenylpropanoid metabolism to OsPep3‐induced rice immunity. Moreover, OsPep3 elicitation also strengthened rice resistance to the fungal pathogen Magnaporthe oryzae and bacterial pathogen Xanthamonas oryzae pv. oryzae and provoked immune responses in wheat. Collectively, this work demonstrates a previously unappreciated importance of the Pep signalling in plants for combating piercing‐sucking insect herbivores and promises exogenous application of OsPep3 as an eco‐friendly immune stimulator in agriculture for crop protection against a broad spectrum of insect pests and pathogens.
Exchange rate uncertainty and foreign direct investment in Africa: Does financial development matter?
Authors: Asamoah Michael Effah , Alagidede Imhotep Paul , Adu Frank 
Published: January 2022

AbstractThe orthodox view is that uncertainty deters investments and, by extension, private capital inflows. Paying specific attention to the volatility of the domestic exchange rate, foreign direct investment (FDI), and financial development indicators, this study investigates the impact of exchange rate uncertainty on FDI and whether financial development matters in such association. We establish our empirical relationship with a system general methods of moments (GMM) two‐step robust estimator with orthogonal deviations. We found evidence supporting a nonlinear U‐shaped relationship between uncertainty and FDI and that the impact of uncertainty on FDI depends on varying levels of uncertainty. We also document that uncertainty deters FDI flows and that countries with a well‐functioning financial development can transform the adverse impact of volatility on FDI. However, curbing the adverse effect depends on the specific indicator and the threshold value of financial development (financial institutions or financial markets).
RMB misalignment: What does a meta‐analysis tell us?
Authors: Cheung Yin‐Wong , He Shi 
Published: January 2022

AbstractUsing a dataset of 3108 dichotomous renminbi (RMB) misalignment estimates from 95 studies, we conduct a meta‐analysis based on Bayesian model averaging (BMA) to assess the effects of study characteristics on these RMB misalignment estimates. The findings demonstrate that selected study characteristic types systematically influence RMB misalignment estimates, especially time series versus non‐time series approach and co‐integration versus non‐cointegration. Though lean toward RMB undervaluation inference, results from the BMA meta‐analysis and the corresponding median probability model and synthetic practice evaluation do not offer a conclusive statistical inference on RMB misalignment. Specifically, the evidence varies with the configuration of model specification and does not corroborate the RMB undervaluation claim for the periods of “2009–2010” and “2011–2014.”
Physiological levels of 25‐hydroxyvitamin D3 induce a suppressive CD4+ T cell phenotype not reflected in the epigenetic landscape
Authors: Matos Carina , Renner Kathrin , Peuker Alice , Schoenhammer Gabriele , Schreiber Laura , Bruss Christina , Eder Ruediger , Bruns Heiko , Flamann Cindy , Hoffmann Petra , Gebhard Claudia , Herr Wolfgang , Rehli Michael , Peter Katrin , Kreutz Marina 
Published: January 2022

Abstract1,25‐dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D3 has a strong impact on the differentiation and function of immune cells. Here we analysed the influence of its precursor 25‐hydroxyvitamin D3 (25(OH)D3) on the differentiation of human CD4+ T cells applying physiological concentrations in vitro. Our data show that 25(OH)D3 is converted to its active form 1,25(OH)2D3 by T cells, which in turn supports FOXP3, CD25 and CTLA‐4 expression and inhibits IFN‐γ production. These changes were not reflected in the demethylation of the respective promoters. Furthermore, we investigated the impact of vitamin D3 metabolites under induced Treg (iTreg) polarization conditions using TGF‐β. Surprisingly, no additive effect but a decreased percentage of FOXP3 expressing cells was observed. However, the combination of 25(OH)D3 or 1,25(OH)2D3 together with TGF‐β further upregulated CD25 and CTLA‐4 and significantly increased soluble CTLA‐4 and IL‐10 secretion whereas IFN‐γ expression of iTreg was decreased. Our data suggest that physiological levels of 25(OH)D3 act as potent modulator of human CD4+ T cells and autocrine or paracrine production of 1,25(OH)2D3 by T cells might be crucial for the local regulation of an adaptive immune response. However, since no epigenetic changes are detected by 25(OH)D3 a rather transient phenotype is induced.
Free trade agreements partnership and value chain linkages: Evidence from China
Authors: Cheng Dazhong , Wang Jian , Xiao Zhiguo 
Published: January 2022

AbstractAs multilateral trade negotiations have lapsed into stalemate, regional economic integration arrangements like free trade agreements (FTAs) are gaining growing prominence. We propose a theory on how a developing country's GVC linkages with partners are affected by partners’ position on the GVCs and the characteristics of the FTAs, and use a large matched data of China's trading partners to validate our hypothesis. We find that there are stronger value chain linkages between China and higher‐income economies, and the degree of mutual value chain dependence rises in line with the partner's development level. The GVC promoting effect of FTA partnership is more pronounced for China's value chain linkages with its higher‐income partners. The results survive various robustness checks and are likely to be informative for other developing countries.