bluuebunny/crossref_metadata_2025_split huggingface dataset:
Added value of high-resolution regional climate model in simulating precipitation based on the changes in kinetic energy
Authors: Kim Gayoung , Kim Jineun , Cha Dong-Hyun 
Published: October 2022

AbstractAs the resolution of regional climate models has increased with the development of computing resources, Added Values (AVs) have always been a steady research topic. Most previous studies examined AVs qualitatively by comparing model results with different model resolutions qualitatively. This study tried to quantitatively investigate the AV of the high-resolution regional climate model for precipitation by analyzing the distribution of kinetic energy according to the different wavelengths at two different resolutions (36 km vs. 4 km), away from the traditional comparative analysis. In addition, the experiment that the low-resolution topography was forced to the high-resolution model was additionally conducted to separate the AVs associated with the topographic effect. Among the three experiments, two with the same topography and two with the exact horizontal resolution were compared separately. With identical topography, the high-resolution model simulated amplified precipitation intensity more than the low-resolution model in all quantiles, especially for extreme precipitation. The precipitation generated by mesoscale or smaller scale weather/climate events was also simulated with greater intensity in the high-resolution model. With the same grid spacing, the more detailed topography model showed AV for increasing spatial variability of precipitation, especially in mountainous regions. The AVs identified in this study were related to kinetic energy with wavelengths at the meso-beta or smaller scale. On the other hand, the kinetic energy above the meso-alpha or larger scale has no significant correlation with the AV of precipitation.
Diagnosis and clinical implication of collision gastric adenocarcinomas: a case report
Authors: Imataki Hiromitsu , Miyake Hideo , Nagai Hidemasa , Yoshioka Yuichiro , Yuasa Norihiro , Takamizawa Junichi , Kiriyama Ayami , Fujino Masahiko 
Published: October 2022

Abstract
Background
Collision tumors are a subtype of simultaneous tumors wherein two unrelated tumors collide or infiltrate each other. Collision gastric adenocarcinomas (CGA) are rare and difficult to diagnose, and their clinical implications remain unclear. Herein, we aimed to reveal diagnostic methods for CGA and provide insight into its implications.

Case presentation
Among 1041 cases of gastric cancers (GCs) resected between 2008 and 2018, we included cases of confirmed CGA. Patients’ backgrounds, preoperative endoscopy findings, macroscopic imaging findings, and histopathology findings [including immunostaining for CK 7, MUC2, and mismatch repair (MMR) proteins] were investigated. The incidence of CGA was 0.5%: 5 of 81 cases having simultaneous multiple GCs. Tumors were mainly in the distal stomach. The CGA in two cases was between early cancers, in two cases was between early and advanced cancers, and in one case was between advanced cancers. There were three cases of collision between differentiated and undifferentiated types and two cases between differentiated types. Immunostaining with CK7 and MUC2 was useful for diagnosing collision tumor when the histology was similar to each other. Among ten GCs comprising CGA, nine tumors (90%) exhibited deficient MMR proteins, suggesting high microsatellite instability (MSI).

Conclusions
CGA is rare and usually found in the distal stomach. Close observation of shape, optimal dissection, and detailed pathological examination, including immunostaining, facilitated diagnosis. CGAs may have high MSI potential.
Robot-assisted total pelvic exenteration for rectal cancer after neoadjuvant chemoradiotherapy: a case report
Authors: Kihara Kyoichi , Koyama Yuri , Hanaki Takehiko , Miyatani Kozo , Matsunaga Tomoyuki , Yamamoto Manabu , Morizane Shuichi , Tokuyasu Naruo , Sakamoto Teruhisa , Fujiwara Yoshiyuki 
Published: October 2022

AbstractBackgroundThere are numerous indications for minimally invasive surgery. However, the laparoscopic approach for extended pelvic surgery is currently provided by only a few institutions specializing in cancer treatment, primarily because of technical difficulties that arise in cases involving a narrow pelvis and rigid forceps. We report a case of robot-assisted total pelvic exenteration for rectal cancer involving the prostate. We assessed the feasibility of robot-assisted total pelvic exenteration and compared the short-term outcomes of other conventional and minimally invasive approaches.Case presentationA 67-year-old man was referred to our hospital after positive fecal blood test results. The initial diagnosis was clinical T4bN2aM0, Stage IIIC rectal cancer involving the prostate. The patient underwent neoadjuvant chemoradiotherapy. Consequently, robot-assisted total pelvic exenteration with an ileal conduit and end colostomy creation were performed. The total operative duration was 9 h and 20 min. The durations of robot console usage by the colorectal and urological teams were 2 h 9 min and 2 h 23 min, respectively. The patient was discharged on postoperative day 21. The pathological diagnosis was T4b (prostate) N0M0, Stage IIC. The resection margin was 2.5 mm. During reassessment at 2 years after resection, no evidence of recurrence was observed.ConclusionsRobot-assisted total pelvic exenteration was performed for a patient with advanced rectal cancer without serious complications. Robot-assisted total pelvic exenteration may provide the advantages of minimally invasive surgery, particularly in the enclosed space of the pelvis.
Laparoscopic distal gastrectomy for gastric cancer in a patient with situs inversus: a case report
Authors: Sato Kei , Yamada Junki , Meguro Naohito , Onishi Hiroshi , Den Kanechika , Baba Hiroyuki , Sugita Mitsutaka 
Published: October 2022

Abstract
Background
Situs inversus (SI) is a rare congenital condition characterized by organ transposition from their normal positions. Careful preoperative planning is important for the safe operation of patients with SI because only a few surgeons have operated on such patients. Here, we report the case of a patient with SI who underwent laparoscopic distal gastrectomy (LDG) with D2 lymph node dissection (LND) for advanced gastric cancer (GC).

Case presentation
The patient was a 72-year-old man diagnosed with GC. Upper endoscopy revealed a type 3 tumor in the anterior wall of the stomach body. Multidetector computed tomography showed no obvious GC metastasis or inverted organs. The preoperative diagnosis was cStage IIB (i.e., cT3, cN0, and cM0) GC with SI. Although liver retracting and intracorporeal suturing required special attention, LDG with D2 LND and Billroth-I reconstruction were safely performed by reversing the usual procedure. The patient was discharged 10 days after the surgery.

Conclusions
To safely perform laparoscopic surgery for GC in patients with SI, sufficient preoperative preparation is necessary. In particular, a reversible method of liver retraction should be prepared.
The reach of fertility decline: a longitudinal analysis of human capital gains across generations
Authors: Koning Stephanie M. , Palloni Alberto , Nobles Jenna , Coxhead Ian , Fernald Lia C. H. 
Published: October 2022

AbstractThe impact of fertility decline on economic development remains central to population studies. Recent scholarship emphasizes parental investment in education as a mediator. We further develop the theoretical foundation, and empirical evidence, for the role of child health—specifically how fertility changes promote children’s physical and cognitive development and thereby complement human capital accumulation through educational gains. We test this using a two-generation model applied to Indonesian longitudinal data from 1993 to 2015. Characteristics of modern fertility regimes—older maternal ages, longer interpregnancy intervals, and lower average birth orders—generally benefit offspring cognitive development and schooling. We estimate that family planning expansion, and the resulting shift in fertility traits, induced an average increase of 0.34 years of offspring educational attainment by age 18 years. Maximal maternal educational and family planning expansion would jointly produce a 1.12-year gain, including 0.20 years more directly attributable to fertility shifts. Evidence is strengthened in parallel simulations from models of within-mother shifts, in which fertility shifts resulted in a 0.16-year gain in offspring schooling. Findings contribute new evidence for the rounding effects of women’s education and family planning expansion on human capital formation through child health within families and across generations.
Antifungal and growth activity of strains of Trichoderma spp. against the Avocado “tristeza” disease, Phytophthora cinnamomi
Authors: Montes Vergara Donicer E. , Barboza-García Adrian , Pérez-Cordero Alexander 
Published: October 2022

AbstractBackgroundAvocado “tristeza,” a disease caused byPhytophthora cinnamomi, is one of the main limiting factors of avocado production in the Caribbean region. To control the pathogen, the application of agrochemicals is required, but this has caused environmental problems.Trichodermaspp. present properties in promoting plant growth and controlling phytopathogens, being proposed as an alternative to replace chemical fertilizers. The objective of the study was to evaluate the antagonistic activity ofTrichodermaspp. againstP. cinnamomiand its possible potential for promoting plant growth in vitro. Soil samples were taken from avocado cultivars from the municipalities of Ovejas (Sucre-Colombia) and Chalán (Sucre-Colombia).ResultsSerial dilutions were carried out for the isolation ofTrichodermaspp. Once the strains were purified, the antagonism test againstP. cinnamomiwas carried out in PDA culture medium. For growth promotion, SRS medium was used for phosphate solubilization and CAS medium for siderophore production. DNA extraction and identification of the isolates were performed using the tef1 gene.Trichoderma harzianumandT. asperellumpresented a 93.4% inhibition against the pathogen, followed byT. viridewith an inhibition of 83.5% and finallyT. longibrachiatumwith 78.4% inhibition, showing significant differences in the control of the growth of the pathogen (p < 0.05) and promoted plant growth. These species release enzymes that can degrade the cell wall of the pathogen causing its death or inhibit its growth through the production of secondary metabolites.ConclusionsThe results showed that the application ofTrichodermaspp. in crops confers protection against pathogens and stimulates the growth of plants to obtain a high yield.
Serum vitamin D level in COVID-19 patients and its correlation with disease severity
Authors: Morad Caroline S. , Habeeb Reem A. , Yassin Esraa T. , Khalil Salma A. 
Published: October 2022

Abstract
Background
Severe coronavirus disease 2019 (COVID-19) infections are associated with increased levels of C-reactive protein (CRP) and several pro-inflammatory cytokines leading to cytokine storm. Vitamin D has been proved to be associated with biological activities of the innate and adaptive immune systems. There is a growing number of data showing an association between serum vitamin D level and the different clinical outcomes of COVID-19 infection. Our aim is to evaluate the relation between serum vitamin D levels and the severity and mortality of COVID-19 infection in an Egyptian cohort.

Results
The study included 80 COVID-19 patients, 38 males (47.5%) and 42 females (52.5%), with a mean age of 52 ± 11.4 years (18–80 years). The serum vitamin D levels ranged between 2 and 30 ng/mL with a mean of 12.05 ± 9.04. Patients who were intubated had the lowest levels of serum vitamin D (7.26 ng/ml ± 5.21), while patients who had no need for oxygen supply had the highest levels (20.00 ng/ml ± 9.23) (P = 0.025). A highly significant negative correlation was found between serum vitamin D level and each of CRP and serum ferritin (r = − 0.346 and − 0.313) (P = 0.002 and 0.005). Of the enrolled 80 patients, 63 (79%) recovered (group 1) and 17 (21%) died (group 2). Group 2 had significantly lower vitamin D levels (6.17 ng/mL ± 3.22) and hemoglobin (10.75 ± 1.74) than group 1 patients (13.63ng/mL ± 9.46) (12.10 ± 1.85) (P = 0.002 and 0.009 respectively).

Conclusion
Serum vitamin D levels are significantly lower in patients needing mechanical ventilation, and in deceased patients, and are inversely related to the inflammatory markers CRP and serum ferritin, suggesting a relation between vitamin D insufficiency and poor COVID-19 outcome.
In the liminal spaces of mental health law – what to do when section 136 expires?
Authors: Hassanally Khalil , Laing Judy , Kishore Anupam 
Published: October 2022

SummaryThe pressure on mental health services has not gone unremarked and is of widespread concern in England and Wales. This can have implications when a bed is being sought for a patient who has undergone a Mental Health Act assessment and is deemed to meet the criteria for being formally admitted to hospital. Once the 24 h period for assessment under section 136 of the Act has lapsed, the ongoing detention of the patient can lead to a legal grey area. Through a fictional example this paper examines the relevant case law and statute that may be used to continue the detention and explores the ethical problems that this may cause.
Prostate Cancer Screening Disparities in Persons Experiencing Homelessness
Authors: Mayo Zachary S. , Kilic Sarah S. , Weleff Jeremy , Parker Sean M. , Strzalka Colleen , Phelan Michael , Mian Omar Y. , Stephans Kevin L. , Suh John H. , Tendulkar Rahul D. 
Published: October 2022

PURPOSE: The purpose of this study was to assess prostate-specific antigen (PSA) testing rates in persons experiencing homelessness (PEH), identify factors associated with screening, and compare PSA screening rates in PEH with a matched cohort of persons not experiencing homelessness (non-PEH). MATERIALS AND METHODS: We identified 9,249 potentially eligible PEH cared for at a large metropolitan hospital system from an institutional registry of all patients who presented to the health care system as homeless from 2014 to 2021. Homelessness was defined by the presence of the Z-code for homelessness (Z59), the listed address matching to the address of a homeless shelter or other transitional housing or a positive screen for homelessness. A matched cohort of 10,000 non-PEH was generated for comparison. Univariate chi-square analysis and multivariate logistic regression were performed to evaluate variables associated with PSA testing. RESULTS: A total of 1,605 PEH and 3,413 non-PEH were eligible for PSA screening within the study timeframe. Half of PEH were Black (50%). Medicaid was the most common insurance (51%), followed by Medicare (18%). PEH were less likely to have a PCP (58% v 81%, P < .001) and had a significantly lower PSA testing rate (13% v 34%, P < .001) compared with non-PEH. Univariate analysis revealed that PSA testing was more common in PEH who were employed ( P < .001), had private insurance or Medicare ( P < .001), or had an established primary care provider (PCP; P < .001). Multivariate analysis confirmed that having a PCP (OR, 2.54; 95% CI, 1.62 to 4.00; P < .001) significantly increased the likelihood of PSA testing in PEH. CONCLUSION: PEH experience low rates of prostate cancer screening. Interventions to increase screening in this population, including increased PCP access, are needed.
Nonplanar Aromatic Hydrocarbons: Design and Synthesis of Highly Strained Structures
Authors: Segawa Yasutomo 
Published: October 2022

Abstract
Aromatic hydrocarbons are indispensable components of functional organic materials. An sp2-hybridized carbon atom can form a nonplanar structure through an appropriate molecular design, and this structural flexibility enables the construction of a wide variety of nonplanar aromatic hydrocarbons. We have studied the chemistry of nonplanar aromatic hydrocarbons and succeeded in synthesizing highly strained structures. The key to this series of studies is the development of innovative strain-release methods. This account introduces our 10-year research campaign on the synthesis of highly strained nonplanar aromatic hydrocarbons, categorized into (i) ring-shaped arenes (e.g., cycloparaphenylenes), (ii) belt-shaped arenes (e.g., carbon nanobelts), (iii) warped arenes (e.g., warped nanographenes), (iv) helical arenes, and (v) topologically unique arenes.
Case Report: Interstitial-intralesional laser therapy and laser-assisted new attachment procedure for the treatment of alveolar bone loss provoked by an aggressive pyogenic granuloma
Authors: Akkarapatum Anon , Klanrit Poramaporn , Sattayut Sajee 
Published: October 2022

Background: A pyogenic granuloma (PG) is a common benign vascular lesion found in the oral cavity. The gold standard treatment of this lesion, comprising surgical excision and the elimination of etiological factors, cannot avoid tooth loss in the case of an aggressive pyogenic granuloma. Because of the prominent properties of 980 nm and 635 nm diode lasers in photocoagulation and photobiomodulation, we applied these wavelengths in the treatment of a large pyogenic granuloma with alveolar bone loss. Case presentation: Our objective was to use a combination of interstitial-intralesional laser therapy, photocoagulation and laser-assisted new attachment procedure (LANAP) to preserve the teeth and periodontal tissue in a case of an aggressive pyogenic granuloma. Results: The patient was a 13-year-old Thai male with a pyogenic granuloma involving the interdental papilla and lingual gingiva of the lower left first and second molars. The teeth were also displaced by the lesion. After treatment with three sessions of photocoagulation, three sessions of interstitial-intralesional laser therapy and two sessions of LANAP, the lesion was completely resolved. The periodontal status of the teeth was improved at the six-month follow-up. Conclusion: The combination of interstitial-intralesional laser therapy, photocoagulation and LANAP was able to treat an aggressive pyogenic granuloma with tooth preservation.
Aspergillus oryzae attenuates quorum sensing -associated virulence factors and biofilm formation in Klebsiella pneumoniae extended-spectrum beta-lactamases
Authors: Rachma Lailia Nur , Fitri Loeki Enggar , Prawiro Sumarno Reto , Mardining Raras Tri Yudani 
Published: October 2022

Background: Klebsiella pneumoniae communicate between and among species using quorum sensing (QS). Biofilm formation and virulence factors are regulated by QS. This QS is indirectly responsible for K. pneumoniae pathogenicity. Inhibiting QS is a novel and highly effective method for controlling K. pneumoniae extended-spectrum beta-lactamases (KP-ESBL) infections. This study aimed to investigate how Aspergillus oryzae extracellular protein (AOEP) affected QS and KP-ESBL virulence factors. Methods: Methods used included minimal inhibitory concentration (MIC) through the microdilution method, biofilms with crystal violet staining, extracellular polysaccharides using the Congo Red assay, quantifying the expression of genes coding for capsular polysaccharide (wzI gene) and adhesion (mrkA gene) through quantitative reverse-transcription polymerase chain reaction (RT-qPCR), siderophore level measurement using Chrome Azurol sulphonate assay (CAS assay), biofilm morphology using a scanning electron microscope (SEM), and confirmation using the life span killing assay method on Caenorhabditis elegans (C. elegans). Results: In vitro studies revealed that AOEP inhibited biofilms and exopolysaccharides (EPS) in KP-ESBL at the sub-MIC level. In addition, AOEP inhibited the expression of the mrkA gene, which is involved in the adhesion process. Furthermore, an in vivo study revealed that AOEP levels of 75 and 150 µg/mL respectively increased C. elegans survival rates by 72.67% and 80.76% against K. pneumoniae infection. Conclusions: Our findings suggest that the extracellular protein of A. oryzae may be an effective QS inhibitor and a novel anti-virulence agent to control bacterial pathogens.
Sex-related differences in symptom presentation of patients with aneurysmal subarachnoid hemorrhage
Authors: Westphal Laura Philine , Bögli Stefan Yu , Werner Jana , Casagrande Francesca , Keller Emanuela , Brandi Giovanna 
Published: October 2022

Background: In patients with myocardial infarction, atypical symptoms at onset have been demonstrated in women. We aimed to investigate the presence of sex-related differences in symptom presentation in patients with aneurysmal subarachnoid hemorrhage (aSAH) to enable earlier diagnosis and treatment. Methods: We assessed symptoms on admission to hospital in 343 patients with aSAH in this retrospective single-center cohort-study. Univariate statistical analysis was performed by comparing sexes including the whole study population and subgroups (dichotomized using Fisher scale 1-2 vs. 3-4, WFNS grade 1-3 vs. 4-5, and anterior vs. posterior circulation aneurysms, respectively). Results: The majority of patients was female (63.6%, n=218, vs. 36.4%, n=125), the mean age 57.4 years (standard deviation (SD) 13.3) with older women compared to men (59.2, SD 13.8, vs. 54.4, SD 11.6; p=0.003). Anterior communicating artery (AcomA) aneurysms were most common (30.9%, n=106), predominantly in men (43.2%, n=54, vs. 23.9%, n=52; p=0.0002), whereas posterior communicating artery (PcomA) aneurysms were more frequent in women (19.3%, n=42, vs. 8.8%, n=11; p=0.005). Exercise-induced headache was more often reported by men (10.4%, n=13, vs. 5%, n=11; p=0.04) in all patients as well as in the subgroup of WFNS 1-3. Anisocoria was more frequent in women within the subgroup of severely impaired consciousness (WFNS 4-5; 25.3%, n=22, vs. 10.7%, n=6; p=0.032). For all other symptoms, there was no evidence for sex-specific differences in the whole study group as well as in subgroups. Conclusion: Our results show no evidence for relevant sex-related differences in symptom presentation at onset in aSAH patients. Women presenting with an acute onset anisocoria should be screened even more carefully for an underlying ruptured Pcom aneurysm.
Associated predictor covariates of cervical cancer stage and impact on survival at Khartoum oncology hospital, Sudan
Authors: Elgoraish Amanda , Alnory Ahmed 
Published: October 2022

Background: Cervical cancer can be invasive and advanced at diagnosis causing devastating suffering and premature death. The cancer stage at presentation is related to survival evaluation and several factors determine stage. The aim of the study was to examine predictors covariates associated with cervical cancer stage at diagnosis and its impact on patient prognosis and survival. Methods: This retrospective cross-sectional study was carried out at Khartoum oncology hospital, Sudan. Participants were 239 cervical cancer patients diagnosed and treated between 2011-2015. Patients’ pathological and socio-demographic data were extracted from their medical files and survival times were calculated from follow-up. Chi-square, Kaplan-Meier, Log-rank test and Cox regression model were used to examine relationships between demographic and clinical variables and survival outcome. Results: The mean age of the participants was 56.91 years and the majority were ≥45 years. Cancer survival analysis showed that the stage at diagnosis had limited association with socio-demographic factors, except where patients reside. Multivariate regression using the Cox proportional hazard model confirmed strongly that stage (p=0.035), chemotherapy (p=0.000) and radiotherapy (p=0.001) were the most likely predictor covariates of patient prognosis and survival time. Conclusions: The results of this study suggest cancer stage at diagnosis and certain treatments are the most important factors impacting the prognosis and survival of patients with cervical cancer. Early detection and vaccination of women against HPV infection provide enormous opportunities for early diagnosis, more effective treatment and better chances of survival.