bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUKUM ISLAM TENTANG ABORSI TERHADAP JANIN YANG DIKETAHUI CACAT
Authors: Zen Fuad 
Published: December 2022

Data menyebutkan bahwa lebih dari satu juta wanita Indonesia melakukan aborsi setiap tahunnya. Dari jumlah tersebut sekitar 50% berstatus belum menikah, 10%-21% di antaranya dilakukan oleh remaja, 8%-10% kegagalan KB, dan 2%-3% kehamilan yang tidak diinginkan oleh pasangan menikah. Kenyataan ini menunjukkan tingginya kebutuhan terhadap praktik aborsi dan beragamnya faktor penyebab aborsi. Pada umumya wanita melakukan aborsi karena disebabkan oleh beberapa hal, di antaranya; dorongan ekonomi, adanya kekhawatiran bahwa janin dalam kandungan akan lahir dalam keadaan cacat, dorongan moral akibat hubungan biologis yang tidak memperhatikan moral dan agama, dan juga dorongan lingkungan. Di kalangan ulama fikih, berbeda pendapat mengenai kebolehan aborsi, bagi yang membolehkan, yakni sebelum peniupan ruh, dengan alasan, pada tahapan itu makhluk belum bernyawa. Sementara ulama yang tidak membolehkan, berpendapat sejak terjadi konsepsi (bertemunya sperma dan ovum), haram melakukan aborsi, sebab sudah ada kehidupan pada kandungan yang sedang mengalami pertumbuhan dan persiapan untuk menjadi makhluk baru yang bernama manusia yang harus dihormati dan dilindungi eksistensinya. Pendapat yang disepakati fuqaha, yaitu bahwa haram hukumnya melakukan aborsi setelah ditiupkannya ruh (usia kehamilan empat bulan). Terlepas dari ulama yang membolehkan atau melarang, pada prinsipnya pengguguran kandungan itu haram. Meskipun keharamannya bertingkat-tingkat sesuai dengan perkembangan kehidupan janin. Tetapi untuk keadaan tertentu dengan sejumlah alasan tertentu yang dibenarkan secara medis dan syar’i, maka aborsi dapat dilakukan. Bagaimana dengan janin yang cacat, apakah kondisi tersebut dapat dijadikan alasan medis untuk melakukan aborsi?.Kemajuan ilmu kedokteran sekarang tidak diragukan, namun demikian, tidaklah dipandang akurat jika dokter membuat dugaan bahwa setelah lahir nanti si janin (anak) akan mengalami cacat—seperti buta, tuli, bisu—dianggap sebagai sebab yang memperbolehkan digugurkannya kandungan. Dalam kenyataan banyak yang mengenal kelebihan para penyandang cacat ini. Namun demikian, pada fase 40 hari pertama, boleh digugurkan jika terdapat maslahat yang mendesak secara syari’at, atau untuk menghindari bahaya yang pasti terjadi. Di antaranya adalah jika janin ini dibiarkan hidup, akan cacat secara fisik dan membahayakan dirinya.
Solution of Large Sparse System of Linear Equations over GF(2) on a Multi Node Multi GPU Platform
Authors: Rawal Shruti , Gupta Indivar 
Published: December 2022

We provide an efficient multi-node, multi-GPU implementation of the Block Wiedemann Algorithm (BWA)to find the solution of a large sparse system of linear equations over GF(2). One of the important applications ofsolving such systems arises in most integer factorization algorithms like Number Field Sieve. In this paper, wedescribe how hybrid parallelization can be adapted to speed up the most time-consuming sequence generation stage of BWA. This stage involves generating a sequence of matrix-matrix products and matrix transpose-matrix products where the matrices are very large, highly sparse, and have entries over GF(2). We describe a GPU-accelerated parallel method for the computation of these matrix-matrix products using techniques like row-wise parallel distribution of the first matrix over multi-node multi-GPU platform using MPI and CUDA and word-wise XORing of rows of the second matrix. We also describe the hybrid parallelization of matrix transpose-matrix product computation, where we divide both the matrices row-wise into equal-sized blocks using MPI. Then after a GPU-accelerated matrix transpose-matrix product generation, we combine all those blocks using MPI_BXOR operation in MPI_Reduce to obtain the result. The performance of hybrid parallelization of the sequence generation step on a hybrid cluster using multiple GPUs has been compared with parallelization on only multiple MPI processors. We have used this hybrid parallel sequence generation tool for the benchmarking of an HPC cluster. Detailed timings of the complete solution of number field sieve matrices of RSA-130, RSA-140, and RSA-170 are also compared in this paper using up to 4 NVidia V100 GPUs of a DGX station. We got a speedup of 2.8 after parallelization on 4 V100 GPUs compared to that over 1 GPU.
Freikirche – Anmerkungen zu einem konfessionskundlich komplizierten Begriff
Authors: Voigt Karl Heinz 
Published: December 2022

Zusammenfassung
Das Wort „Freikirche“ ist auch rund 150 Jahre nach seiner Entstehung ein konfessionskundlich nicht eindeutiger Begriff. Daher wird in diesem Beitrag vorgeschlagen, den Ausdruck „Minderheitskirchen“ zu verwenden, um lokalgemeindlich orientierte Bünde, weltweit verfasste Kirchen und konfessionell begründete Kirchen einerseits von nichtverfassten, sich selbst so apostrophierenden „freikirchlichen“ Gemeinschaften andererseits zu unterscheiden.
Orthodoxie und Moderne
Authors: Pilhofer Philipp 
Published: December 2022

Zusammenfassung
Das Verhältnis der östlich-orthodoxen Kirchen zur „Moderne“ wird seit langem immer wieder diskutiert. Am Umgang der orthodoxen Kirchen mit der Corona-Pandemie lassen sich neue Perspektiven auf dieses Thema gewinnen. Daher wird hier am Beispiel von Kirche und Gesellschaft in Griechenland der Umgang mit der Pandemie beleuchtet und hinsichtlich des Verhältnisses zur „Moderne“ mit der Lage in Deutschland differenziert vergleichend ausgewertet.
Physiological and modulatory role of thioredoxins in the cellular function
Authors: Xinastle-Castillo Luis Omar , Landa Abraham 
Published: December 2022

Abstract
Thioredoxins (TRXs) are a class of ubiquitous and multifunctional protein. Mammal cells present three isoforms: a cytosolic and extracellular called thioredoxin 1 (TRX1), a mitochondrial (TRX2), and one specific in spermatozoids (TRX3). Besides, a truncated form called TRX80 exists, which results from the post-translational cleavage performed on TRX1. TRXs’ main function is to maintain the reduction–oxidation homeostasis of the cell, reducing the proteins through a thiol-disulfide exchange that depends on two cysteines located in the active site of the protein (Cys32-X-X-Cys35 in humans). In addition, TRX1 performs S-nitrosylation, a post-translational modification of proteins that depends on cysteines of its C-terminal region (Cys62, Cys69, and Cys73 in human TRX1). These modifications allow the TRXs to modulate the protein function and participate in regulating diverse cellular processes, such as oxidative stress, transcription, signaling cascades, apoptosis, inflammation, and immunologic response. This points out the crucial relevance of TRXs for cell function, signaling it as a strategic target for the treatment of many diseases and its possible use as a therapeutic factor.
Basal Forebrain Chemogenetic Inhibition Converts the Attentional Control Mode of Goal-Trackers to That of Sign-Trackers
Authors: Kucinski Aaron , Avila Cassandra , Sarter Martin 
Published: December 2022

AbstractSign tracking versus goal tracking in rats indicate vulnerability and resistance, respectively, to Pavlovian cue-evoked addictive drug taking and relapse. Here, we tested hypotheses predicting that the opponent cognitive-behavioral styles indexed by sign tracking versus goal tracking include variations in attentional performance which differentially depend on basal forebrain projection systems. Pavlovian Conditioned Approach (PCA) testing was used to identify male and female sign-trackers (STs) and goal-trackers (GTs), as well as rats with an intermediate phenotype (INTs). Upon reaching asymptotic performance in an operant task requiring the detection of visual signals (hits) as well as the reporting of signal absence for 40 min per session, GTs scored more hits than STs, and hit rates across all phenotypes correlated with PCA scores. STs missed relatively more signals than GTs specifically during the last 15 min of a session. Chemogenetic inhibition of the basal forebrain decreased hit rates in GTs but was without effect in STs. Moreover, the decrease in hits in GTs manifested solely during the last 15 min of a session. Transfection efficacy in the horizontal limb of the diagonal band (HDB), but not substantia innominate (SI) or nucleus basalis of Meynert (nbM), predicted the behavioral efficacy of chemogenetic inhibition in GTs. Furthermore, the total subregional transfection space, not transfection of just cholinergic neurons, correlated with performance effects. These results indicate that the cognitive-behavioral phenotype indexed by goal tracking, but not sign tracking, depends on activation of the basal forebrain-frontal cortical projection system and associated biases toward top-down or model-based performance.
BiVaSE: A bilingual variational sentence encoder with randomly initialized Transformer layers
Authors: Nyéki Bence 
Published: December 2022

AbstractTransformer-based NLP models have achieved state-of-the-art results in many NLP tasks including text classification and text generation. However, the layers of these models do not output any explicit representations for texts units larger than tokens (e.g. sentences), although such representations are required to perform text classification. Sentence encodings are usually obtained by applying a pooling technique during fine-tuning on a specific task. In this paper, a new sentence encoder is introduced. Relying on an autoencoder architecture, it was trained to learn sentence representations from the very beginning of its training. The model was trained on bilingual data with variational Bayesian inference. Sentence representations were evaluated in downstream and linguistic probing tasks. Although the newly introduced encoder generally performs worse than well-known Transformer-based encoders, the experiments show that it was able to learn to incorporate linguistic information in the sentence representations.
Adherence to preprints’ publication in Dentistry by Brazilian researchers
Authors: Cenci Jaisson , Cruz Daiane Silva Santos Da , Leite Pedro Dentice Da Silva , Montagner Anelise Fernandes , Cenci Maximiliano Sérgio 
Published: December 2022

Aim: The publication in preprint format is an interesting open science practice that allows fast outreach to the society of new scientific findings. However, no previous study has investigated how much this practice has been adopted by dental scientists. Therefore, the objective of this study was to evaluate the adherence to the preprint publication format by a sample of Brazilian researchers.
Methods: Searches were carried out, in September 2021, on the MedArxiv, OSF, and SciELO preprints platforms, looking for publications in preprint format by all Brazilian researchers of graduate programs in dentistry (n=211) who were productivity fellows in 2021 (PQ). Searches were performed by typing the authors’ full names and the possible variations, as indicated by each author's curriculum, openly available on the Lattes website platform. The data were analyzed through the Friedman test, with the Durbin-Conover post-hoc (α=0.05) in order to compare the three platforms. Spearman's correlation test (α=0.05) was performed to assess the possible correlations between the number of preprints and age, career stage, and the researcher’s scholarship level variables.
Results: From the 211 researchers searched, 22 (10.4%) published 1 (one) preprint on at least one platform. A total of 39 published preprints were found at MedArxiv (n=19, 48.7%), SciELO preprints (n=18, 46.2%), and OSF platforms (n=2, 5.1%). There was no difference between the adherence to MedArxiv and SciELO preprints (p = 0.731). However, the OSF platform presented the lowest adherence, statistically differing from MedArxiv (p=0.008) and SciELO preprints platforms (p=0.003). In addition, no correlation was found between the publication of preprints and the researcher's age (p=0.128), career stage (p=0.248), or the researcher's scholarship level (p=0.661).
Conclusion: It was possible to observe a low adherence to the preprints publications by Brazilian researchers’ productivity fellows of graduate programs in dentistry.
The impact of the COVID-19 pandemic on cancer incidence and cancer care in patients with prostate cancer in the Siberian Federal District
Authors: Zhuikova L. D. , Ananina O. A. , Pikalova L. V. , Kononova G. A. 
Published: December 2022

Background. Prostate cancer incidence rates continue to increase every year, therefore, the study of the quality indicators for cancer care, especially during a pandemic, is of great importance.Aim. To analyze prostate cancer incidence rates and quality indicators of cancer care in the Siberian Federal District.Materials and methods. For the calculation of cancer incidence rates, population-bases cancer registry data were used. Quality indicators were calculated according to the methodological recommendations of P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center.Results. The implementation of restrictive measures and the suspension of cancer screening programs in 2020 negatively affected the cancer care. The prostate cancer incidence rate decreased from 52.8 per 100 000 population in 2019 to 43.1 per 100 000 population in 2020, especially in the territories of the Republic of Tyva and the Omsk Region. Morphological verification in 2020 decreased compared to 2019 (97.0 % versus 97.8 %), with the exception of the Krasnoyarsk Territory and the Republic of Altai. Early prostate cancer detection increased from 62.9 to 64.0 %, and cancer detection at late stages decreased from 36.3 to 35.0 %. One-year mortality in the region decreased from 8.0 % (2019) to 7,3 % (2020), however, it increased significantly in the Republic of Tyva (from 3.2 to 40.0 %) and the Altai Republic (from 3.7 to 10.7 %). The number of patients who have been followed-up for 5 years or more increased from 40.7 to 42.3 %, except for Republic of Altai (from 32.8 to 25.0 %).Conclusion. Delay in the diagnosis of prostate cancer is associated with advanced stage, poor survival and high cost treatment.
Transperitoneal laparoscopic and robot-assisted resection of anterior and posterior kidney tumors
Authors: Guliev B. G. , Komyakov B. K. , Yakubov Kh. Kh. 
Published: December 2022

Background. Laparoscopic and robot-assisted resection of the posterior kidney tumors can be performed through retroperitoneal and transperitoneal accesses. Supporters of retroperitoneal partial nephrectomy point to better results for neoplasms in this location. However, most surgeons use transperitoneal access.Aim. To perform comparative analysis of the results of laparoscopic and robot-assisted partial resection of anterior and posterior renal neoplasms.Materials and methods. The results of transperitoneal minimally invasive partial nephrectomy in 156 patients (86 (55.1 %) men and 70 (44.9 %) women) were analyzed. Anterior tumors (1st group) were diagnosed in 96 (61.5 %), posterior (2nd group) in 60 (38.5 %) patients. In the 1st group, mean tumor size was 3.4 ± 1.6 cm; in the 2nd group, 3.2 ± 1.4 cm. In the 1st group, laparoscopic partial nephrectomy was performed in 70 (72.9 %), robot-assisted in 26 (27.1 %) patients; in the 2nd group in 40 (66.7 %) and 20 (33.3 %) patients, respectively. Comparative analysis of operating time, warm ischemia time, complications and glomerular filtration rate was performed.Results. No conversions into nephrectomy or open interventions were performed. Time of laparoscopic partial nephrectomy in the 1st group was shorter than in the 2nd: 108.6 min versus 120.5 min (р >0.05). In robot-assisted partial nephrectomy it was 90.5 and 112.6 min (р >0.05), respectively. For laparoscopic partial nephrectomy, mean warm ischemia time in the 1st group was 15.0 min, in the 2nd group it was 17.5 min (р >0.05); in robot-assisted operation it was 13.2 and 16.0 min (р >0.05), respectively. Blood loss volume was lower in the 1st group compared to the 2nd: 125 ml versus 230 ml (р <0.05). In all patients, renal cell carcinoma was diagnosed; Т1а tumors were predominant (in the 1st and 2nd group, 87.5 and 88.3 %, respectively; р >0.05). Postoperative complications in transperitoneal resection of anterior tumors were observed less frequently: 16.7 % versus 20.0 % (р >0.05). Grade I complications per the Clavien classification in the 1st and 2nd group were observed in 8 (8.3 %) and 6 (10.0 %) patients, grade II in 6 (6.3 %) and 5 (8.3 %) patients, grade III in 2 (2.1 %) and 1 (1.7 %) patients. After resection, urinary leakage through the drain was observed in 2 (2.1 %) patients of the 1st group and 1 (1.7 %) patient of the 2nd group; they underwent drainage of the upper urinary tract using a stent. Blood transfusion in the postoperative period was performed in 2 patients from each group (2.1 and 3.3 %, respectively). In the 1st group, glomerular filtration rate before and after surgery was 68 and 56 ml/min/1.73 m2, in the 2nd group 70.2 and 58.2 ml/min/1.73 m2, respectively; no significant difference was observed (р >0.05).Conclusion. Transperitoneal access allows to safely perform minimally invasive resection of the anterior and posterior kidney tumors with results comparable to the perioperative results of retroperitoneal partial nephrectomy.
New lenvatinib and pembrolizumab combination for metastatic renal cell carcinoma in 1<sup>st</sup> line drug treatment: comparative effectiveness and safety
Authors: Alekseev B. Ya. , Shevchuk I. M. 
Published: December 2022

Currently, combination immunotarget therapy is the treatment standard for patients with disseminated carcinoma of the renal parenchyma. Simultaneous inhibition of immune checkpoints of programmed cell death 1 (PD-1)/PD-L1 and VEGF/VEGFR signal transduction showed synergistic antitumor effect both in preclinical models and clinical practice.The article presents the results of phase III CLEAR (NCT02811861) trial.In the phase III CLEAR (NCT02811861) trial, 1069 patients with renal cell carcinoma with clear-cell component who previously did not receive systemic antitumor therapy were randomized 1:1:1 in groups of lenvatinib (20 mg/day per os) + pembrolizumab (200 mg intravenously once in 21 days), combination lenvatinib (18 mg/day per os) + everolimus (5 mg/day per os), and sunitinib (50 mg/day per os for 4 weeks with 2-week interval). The groups included 355, 357, and 357 patients respectively. Primary endpoint was progression-free survival (PFS) controlled by expertise of an independent central committee per the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v.1.1). Additionally, patient overall survival (OS) and drug therapy tolerability were evaluated.Median PFS for lenvatinib with pembrolizumab was significantly higher than for sunitinib (23.9 months vs. 9.2 months; progression hazard ratio (HR) 0.39; 95 % confidence interval (CI) 0.32–0.49; p <0.001). Similar advantage in PFS was observed for lenvatinib with everolimus compared to sunitinib (median PFS 14.7 months vs. 9.2 months; HR 0.65; 95 % CI 0.53–0.8; p <0.001). OS also was higher for lenvatinib and pembrolizumab combination compared to sunitinib (death HR 0.66; 95 % CI 0.49–0.88; p = 0.005). No advantages in OS of lenvatinib and everolimus compared to sunitinib were detected (death HR 1.15; 95 % CI 0.88–1.5; p = 0.3). Frequency of grade III and higher adverse events among patients receiving lenvatinib + pembrolizumab, lenvatinib + everolimus, and sunitinib were 82.4, 83.1, and 71.8 %, respectively.Pembrolizumab + lenvatinib combination showed high effectiveness in 1st line treatment of renal cell carcinoma compared to sunitinib per PFS and OS values.
Nomograms for predicting local recurrence in prostate cancer patients with a positive resection margin
Authors: Nyushko K. M. , Perepukhov V. M. , Alekseev B. Ya. 
Published: December 2022

Background. Prostate cancer patients with a positive resection margin after radical prostatectomy are at risk of developing local recurrence. This risk should be carefully estimated in order to choose an optimal management strategy.Aim. To develop a nomogram to predict the risk of local recurrence in patients with a positive resection margin using the data on patients who have undergone surgery.Materials and methods. Routine pathomorphological examination of surgical specimens from 2255 patients with clinically significant local and locally advanced prostate cancer revealed 364 cases of positive resection margin. Statistical analysis allowed us to identify the most significant prognostic factors. Using selected preoperative factors and a mathematical model, we created a nomogram to predict local recurrence in patients with a positive resection margin.Results. Our nomogram had an accuracy of 93% (area under the ROC curve (AUC) 0.9392; p <0.005), sensitivity of 0.99438, and specificity of 0.94545. The most significant prognostic factors included proportion of positive biopsy specimens, Gleason score (International Society of Urological Pathology (ISUP) grade estimated at routine pathomorphological examination), and presence and length of positive resection margin.Conclusion. Our mathematical model and the nomogram based on it are highly accurate for predicting local recurrence and can therefore be used for choosing an optimal management strategy.
Prostate-specific antigen density as a predictor of recurrence-free survival following combined hormonal-radiation therapy of localized prostate cancer
Authors: Kneev A. Yu. , Shkolnik M. I. , Bogomolov O. A. , Verdiev N. D. , Zharinov G. M. 
Published: December 2022

Background. Prostate cancer is amongst one of the most prevalent cancers in men worldwide. Combined hormonal-radiation therapy has become a standard of care for localized prostate cancer definitive treatment. As many as 30 % of men are at risk for disease progression within 10 years following radical treatment.Aim. To assess the significance of prostate-specific antigen (PSA) density as a predictor of recurrence-free survival following combined hormonal-radiation therapy in patients with localized prostate cancer.Materials and methods. We conducted a retrospective study of 272 patients with clinically localized prostate cancer treatment results who received combined hormonal-radiation therapy between January 1996 and December 2016.Results. On the basis of our study, we confirmed high prognostic value of PSA density among patients with localized prostate cancer who received combined hormonal-radiation treatment. We utilized ROC-analysis in order to determine the threshold value of the PSA density index – 0.376 ng/ml/cm3, exceeding of which was associated with statistically significant reduction in the recurrence-free survival rate. The area under the curve was 0.711 (95 % confidence interval 0.653–0.764; p <0.0001). The risk of recurrence increased with rising of PSA density.Conclusion. PSA density has proven to be a reliable tool for assessing the risk of prostate cancer recurrence among patients with localized prostate cancer who have undergone combined hormonal-radiation therapy.