bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia
Authors: Rytkönen Kalle T , Adossa Nigatu , Mahmoudian Mehrad , Lönnberg Tapio , Poutanen Matti , Elo Laura L 
Published: September 2022

In brief
Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.

Abstract
Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.
Prognosis of Children Undergoing Liver Transplantation: A 30-Year European Study
Authors: Baumann Ulrich , Karam Vincent , Adam René , Fondevila Constantino , Dhawan Anil , Sokal Etienne , Jacquemin Emmanuel , Kelly Deirdre A. , Grabhorn Enke , Pawlowska Joanna , D’Antiga Lorenzo , Jara Vega Paloma , Debray Dominique , Polak Wojciech G. , de Ville de Goyet Jean , Verkade Henkjan J. ,   European Liver and Intestine Transplant Association (ELITA) and all ELTR contributing centers
Published: September 2022

OBJECTIVES
The European Liver Transplant Registry has been collecting data on virtually all pediatric liver transplant (PLT) procedures in Europe since 1968. We analyzed patient outcome over time and identified parameters associated with long-term patient outcome.

METHODS
Participating centers and European organ-sharing organizations provided retrospective data to the European Liver Transplant Registry. To identify trends, data were grouped into consecutive time spans: era A: before 2000, era B: 2000 to 2009, and the current era, era C: since 2010.

RESULTS
From June 1968 until December 2017, 16 641 PLT were performed on 14 515 children by 133 centers. The children &lt;7 years of age represented 58% in era A, and 66% in the current era (P &lt;.01). The main indications for PLT were congenital biliary diseases (44%) and metabolic diseases (18%). Patient survival at 5 years is currently 86% overall and 97% in children who survive the first year after PLT. The survival rate has improved from 74% in era A to 83% in era B and 85% in era C (P &lt;.0001). Low-volume centers (&lt;5 PLT/year) represented 75% of centers but performed only 19% of PLT and were associated with a decreased survival rate. In the current era, however, survival rates has become irrespective of volume. Infection is the leading cause of death (4.1%), followed by primary nonfunction of the graft (1.4%).

CONCLUSIONS
PLT has become a highly successful medical treatment that should be considered for all children with end-stage liver disease. The main challenge for further improving the prognosis remains the early postoperative period.
Vandana Shiva e o mundo atual
Authors: Sautchuk Jaime 
Published: September 2022

A física nuclear indiana Vandana Shiva continua a mesma militante, o que tem mudado um bocado (para pior) é a realidade ao redor do planeta em que vivemos. Mas isso apenas reforça suas ideias, conceitos, pregações e ações na busca pelo desenvolvimento sustentável em plena sintonia com a justiça social. Sua formação acadêmica se deu em universidades da própria Índia, do Canadá e dos Estados Unidos. Mas ela prefere se dizer “formada na universidade da floresta”, numa referência Ã sua proximidade com movimentos populares, em particular dos camponeses de seu país. Sua farta obra, com mais de 30 livros publicados ”” além de centenas de artigos, palestras e propostas de lutas ””, há décadas granjeia simpatizantes mundo afora. “Estar ao lado dos últimos”, título de um de seus livros, expressa bem seu sentimento de combate Ã ganância, prepotência e descompromisso daqueles que levam a Humanidade para o caminho da autodestruição. Os “últimos” são aqueles que foram privados pela força de usufruir dos bens que são comuns, mas estão sendo apropriados por poucos. Os mesmos que desprezam a Natureza e se lixam para um futuro de harmonia entre os humanos e o meio em que vivem.
Prestação de Serviços Ambientais pode ser uma alternativa aos sistemas tradicionais da agricultura familiar no município de Pacajá, Amazônia Paraense ”“ Brasil?
Authors: Coelho Britto Guilherme , Ryohei Kato Osvaldo , Herrera José Antônio 
Published: September 2022

Os estabelecimentos familiares, em sua maioria, adotam o sistema tradicional de agricultura, usando a área por um ou dois anos, seguido de pousio. Essa produção, na Amazônia, tem sido identificada, por alguns, como problema social e vilã ecológica. Contraponto a essa visão, compreende-se a agricultura familiar como estratégica na manutenção do emprego, redistribuição da renda, garantia da soberania alimentar do país e a alternativa para o desenvolvimento sustentável, devido Ã diversificação nos sistemas de produção e características equilibradas na relação homem e natureza. Propõe-se no texto a reflexão sobre Prestação de Serviços Ambientais no município de Pacajá-PA. Adotou-se a ferramenta Eco-Cert. PROAMBIENTE desenvolvida pela Embrapa para identificar as práticas contribuintes com os serviços. Os resultados mostraram que a diversificação é fundamental para prestação de serviços ambientais e as famílias participantes do PROAMBIENTE aumentaram o potencial na prestação de serviços, principalmente por não derrubarem as florestas e reduzirem o uso do fogo.
Dossiê: “Políticas públicas de desenvolvimento territorial na América Latina”
Authors: Sabourin Eric , Sayago Doris 
Published: September 2022

O dossiê deste número é dedicado Ã s “Políticas públicas de desenvolvimento territorial em América Latina”. Artigos sobre políticas públicas de desenvolvimento rural ou sobre desenvolvimento territorial e ambiental já foram publicados na revista SeD; no entanto, aqui as duas temáticas foram cruzadas. Esse dossiê foi preparado pelos coordenadores de uma nova rede de pesquisa atuante em escala latinoamericana, a “Rede Políticas públicas e Desenvolvimento Rural na América Latina”.
Cytotoxic and Apoptotic Effects of Polyethylene Nanoparticles on Normal Monkey Kidney Vero E6 Cell Line
Authors: Hussien Nahed Ahmed , Malki Jamila S. Al , Mohammadein Amaal , Tantawy Ehab M. , Khattab Yassir 
Published: September 2022

Background: Nanoplastics (NPs) become one of the most threatening substances for living organisms in the aquatic and terrestrial environments. Due to their small size and high surface area, few studies have revealed their toxic impact on mainly marine organisms. However, there is scarcity on NPs impact on mammalian cells. Methods: We used 200-900 nm polyethylene nanoparticles (PE-NPs) to evaluate their cytotoxic and genotoxic effects on mammalian Vero E6 cell line using MTT and Comet assays. Result: Characterization of the selected PE-NPs confirmed their nano spherical shape, size and their low-density type. Serial dilution of PE-NPs decreases cell viability with 50% inhibition concentration (IC50) 91 μg/mL (at 24 h sampling time), 26 μg/mL (48 h) and 22 μg/mL (72 h) and an average IC50 = 46 μg/mL. Treatment of Vero E6 cells with the average IC50 significantly affects the genomic integrity by decrease of % DNA in head, increase of % DNA in tail, tail length (μm) and tail moment, in a time-dependent manner. Therefore, PE-NPs of the low-density type, that is widely used in different products including coatings and films, have cytotoxic and genotoxic effect on mammalian cells. NPs deserves more attention and further studies are needed to focus on their molecular mechanisms in vitro.
BIMBINGAN ROHANI: STRATEGI KONSELING ISLAM UNTUK MENINGKATKAN RELIGIUSITAS DI LINGKUNGAN PESANTREN
Authors: Syaifatul Jannah  , Ida  
Published: September 2022

Penelitian ini merupakan bimbingan yang diberikan kepada mahasantri berupa nilai-nilai ajaran agama Islam sehingga menjadikan mereka muslimah yang sejati. Adapun tujuan penelitian ini untuk mengetahui bagaimana pelaksanaan dan hasil dari bimbingan rohani islam yang diterapkan kepada mahasantri baru. Metode penelitian yang digunakan dalam penelitian ini yaitu metode kualitatif deskriptif, karena ingin menggambarkan dan mendeskripsikan apa adanya data tentang pelaksanaan bimbingan rohani Islam untuk meningkatkan religiusitas mahasantri baru. Sedangkan alat pengumpulan data menggunakan metode observasi, wawancara dan dokumentasi. Subjek penelitian ini terdiri dari dua subjek yaitu ustadzah bagian peribadatan dan mahasantri baru program intensif di Institut Dirosat Islamiyah Al-Amien Prenduan. Adapun hasil dari penelitian menunjukkan bimbingan rohani Islam yang diberikan berupa kegiatan bimbingan spiritual yaitu: wajib shalat berjama’ah, disunnahkan shalat tasbih, dzikir, shalat tahajjud, shalat sunnah ba’diyah dan qobliyah dan membaca Al-qur’an. Metode yang digunakan adalah metode ta’widiyah (pembiasaan), tulisan, mau’izhah (nasehat), Demonstrasi dan meniru atau jibril. Sedangkan materi yang digunakan berupa akidah. Adapun hasil dari pelaksanaan bimbingan rohani Islam adalah meningkatkan keimanan, dan ketakwaan mahasantri baru, memiliki sikap istiqamah dalam menjalankan perintah Allah SWT, dapat mengambil pelajaran dari apa yang dilihat, meningkatnya keyakinan kepada Allah SWT, memahami pentingnya religiusitas bagi diri dan memiliki akhlak mulia dalam bergaul.
IMPLEMENTASI LANGKAH KERJA KONSELING MODEL KIPAS DALAM MENGEMBANGKAN KARAKTER GENERASI ALPHA
Authors: Muhammad Nikman Naser  , Syukri Hamzah  , Andi Mappiare  
Published: September 2022

Konseling KIPAS merupakan suatu kerangka kerja konseling yang berbasis pada sistem nilai budaya Indonesia. Generasi Alpha yang cukup unik dewasa ini mengharuskan guru BK dan stakeholder untuk senantiasa berkolaborasi dalam membangun karakter siswa. Tujuan penelitian ini untuk mengimplementasikan langkah kerja konseling KIPAS yang terintegrasi pada proses pembelajaran di Sekolah. Penelitian ini menggunakan metode penelitian collaborative action research yaitu peneliti berkolaborasi dalam pelaksanaan layanan BK yang terintegrasi dengan manajamen sekolah dan PBM. Penelitian dilakukan dalam 5 siklus langkah kegiatan. Hasil penelitian menunjukkan setelah dilaksanakan langkah kerja konseling KIPAS terlihat suatu progres dalam memfasilitasi perkembangan karakter siswa.
Pengaruh Ekstrak Rasberi (Rubus occidentalis) terhadap Kadar Asam Urat Tikus Wistar Model Sindrom Metabolik
Authors: Phangadi Milana , Subandono Jarot , - Sarsono 
Published: September 2022

Pendahuluan: Sindrom metabolik yang mencakup hiperinsulinemia, hiperkolestrolemia, dislipidemia, hipertensi, dan juga obesitas dapat memengaruhi kadar asam urat dalam tubuh seseorang. Hiperinsulinemia akan menyebabkan gangguan metabolisme asam urat yang menyebabkan kondisi hiperurisemia. Rasberi merupakan buah yang kaya antosianin yang merupakan flavonoid natural yang menunjukan efektivitas dalam pengobatan sindrom metabolik namun efektivitasnya terhadap kadar asam urat masih kurang banyak diteliti. Penelitian ini bertujuan untuk membuktikan efektivitas rasberi dalam menurunkan kadar asam urat serta melihat pengaruh perbedaan dosis ekstrak rasberi terhadap kadar asam urat pada tikus wistar sindrom metabolik.
Metode: Penelitian ini merupakan penelitian eksperimental laboratorik dengan sampel 30 tikus Wistar dalam 5 kelompok (kontrol dan perlakuan). Tikus diinduksi diet HFFD selama 28 hari lalu diinjeksi STZ-NA dan diukur kadar asam uratnya (pretest) bersama dengan parameter lain (berat badan, glukosa, HDL, dan kolesterol total) untuk memastikan sampel memenuhi kriteria sindrom metabolik. Selanjutnya kelompok perlakuan diberi ekstrak rasberi (Rubus occidentalis) dengan dosis 125 mg/kgBB, 250 mg/kgBB, dan 375 mg/kgBB selama 21 hari lalu diukur kadar asam uratnya (posttest). Kadar asam urat didapat melalui serum darah vena retroorbital yang dianalisis dengan kit DiaSys. Kadar asam urat pretest dan posttest kelompok kontrol dan perlakuan dianalisis menggunakan uji T berpasangan dan One Way ANOVA.
Hasil: Kadar asam urat posttest menurun sebesar 6,39 mg/dL, 7,58 mg/dL, dan 8,74 mg/dL pada kelompok perlakuan. Terdapat perbedaan signifikan (p<0,05) antara rerata kadar asam urat pretest dan posttest serta rerata antar kelompok.
Kesimpulan: Rasberi (Rubus occidentalis) dapat menurunkan kadar asam urat dalam darah dan efeknya semakin besar sebanding dengan jumlah dosis yang diberikan.
Kata Kunci: Sindrom Metabolik, Rasberi (Rubus occidentalis), Asam Urat, Tikus Wiztar
Preoperative Stiffness is the most important Predictor of Postoperative Patient’s Satisfaction after Total Knee Arthroplasty.
Authors: Abdelhameed Mohammed Anter , Abdelnasser Mohammad Kamal , Zaky Bishoy Raafat , Bakr Hatem M. , Aziz Mirette , Mahran Mohamed 
Published: September 2022

Abstract
Purpose
to predict the most important preoperative factor affecting the patient satisfaction after total Knee arthroplasty (TKA) in trial to improve patient counselling process.
Methods
we retrospectively reviewed all patients who underwent primary TKA from 1st of January 2018 to 31st of January 2019 with minimum one year follow up for the previously collected patient reported outcome measures (PROMs) as Oxford Knee Score (OKS) and Knee Injury and Osteoarthritis Outcome Score for joint replacement (KOOS, JR) preoperative, 6 months and 12 months postoperative.
Results
By using Oxford knee score at 12 months as dependent variable, we found a negative moderate spearman correlation between age and oxford score at 12 months postoperative. Moderate negative spearman correlation was also found between oxford score at 12 months postoperative and KOOS pain, stiffness and function scores at preoperative and 6 months postoperative, denoting higher satisfaction at 12 months with less perceived stiffness, pain and limited function at baseline and 6 months postoperative. A multivariate regression analysis was done using the oxford knee score at 12 months as dependent variable to detect the predictors of oxford knee score at 12 months postoperatively and showed that younger age and less perception of stiffness at baseline were significant predictors of higher oxford score; higher satisfaction at 12 months postoperative.
Conclusion
Preoperative stiffness can predict the postoperative satisfaction score more than any other factor. We also address the importance of combining more than one PROM in assessing patients as OKS and KOOS, JR.
SymSwarm: A Two-Staged Decentralized Symmetrical Pattern Formation Paradigm for a Swarm of Mobile Robots
Authors: Istiak Md. Abrar , Ullah Md Saheed , Ashraf Zulqarnain Bin , Sarker Sudipta Chandra , Chowdhury Mortuza Minhaj , Ahbab Sadman Sakib 
Published: September 2022

Abstract
For several decades, cooperative control of autonomous mobile robots has been an active research area with potential applications in dynamic areas such as agriculture, industrial plants, and the military. Although numerous research studies on pattern formation using multiple mobile agents have been conducted, no algorithm for symmetric pattern formation that is independent of the number of agents and prioritizes user control has been introduced. This article demonstrates an attempt to manifest an end-to-end symmetrical pattern in a swarm of mobile robots. Here, a two-staged paradigm named SymSwarm is developed, which incorporates the novelty of forming symmetrical formations around a point within a coveted area via decentralized communication among the swarm. SymSwarm is built on a novel concept of a bio-inspired state model called CPSM (Compete and Point State Model), which enables smarter and more robust computation, and self-regulation. While most bio-inspired models focus on the characteristics of bees, ants, cats, chimps, and a variety of other animals, this paradigm focuses on the competitive sentiment and leadership ability of human beings to shape the CPSM mentioned above. The algorithm for acquiring symmetrical points is developed using the Circle Polygon analogy in cartesian geometry. The following sections propose a decentralized communication mechanism for adjacent consecutive robots, as well as a SymSwarm: A Two-Staged Decentralized Symmetrical Pattern heuristic nearest point finder algorithm. The proposed paradigm is evaluated using a robotics simulator (V-REP), and the results indicate that it is consistently successful and has a low rate of pattern formation error in the presence or absence of obstacles in the environment.
Cationic liposomes as promising vehicles forTimolol/Brimonidine combination ocular delivery in glaucoma: Formulation development and in vitro/in vivo evaluation
Authors: zadeh behzad sharif makhmal , Feghhi Mostafa 
Published: September 2022

Abstract
Glaucoma is a chronic eye disease in which the pressure inside the eye increases and leads to damage to the optic nerve, and eventually causes blindness. In this disease, it is often necessary to use a multi-drug treatment system. There is a fixed combination of Timolol maleate and Brimonidine tartrate among the combination drugs in glaucoma treatment. Liposomes are one of the most important targeted drug delivery systems to eye tissue, which leads to improved drug permeability and durability in ocular tissue.In this study, Thin Layer Hydration was used to make liposomal formulations containing Timolol maleate (TM) and Brimonidine tartrate (BT). After the necessary evaluations, one of the eight initial formulations was selected as an optimization formulation. Then, characteristics such as drug loading percentage, particle size, pH, zeta potential, and drug release were performed on the optimized formulation. The study of reducing intraocular pressure was performed on the optimized formulation. This study in total was performed on 18Rabbits in three groups. Hydroxypropyl methylcellulose (HPMC) polymer was injected into the anterior chamber to Experimental induce glaucoma.The selected formulation was within the acceptable range of ocular products in terms of physical properties. HPMC polymer injection successfully induced glaucoma in the animal model, resulting in a 79% increase in intraocular pressure. The results showed that the liposomal formulation significantly reduced the intraocular pressure compared to the simple formulation of the aqueous solution, and both formulations were able to significantly reduce the intraocular pressure compared to the control group(p < 0.001). The results also showed that liposomal formulation hasa therapeutic effect in reducing intraocular pressure and has a preventive effect and intraocular pressure return to normal value after 90 h. It seems that selected liposomal formulation made by Thin Layer Hydration can act as a suitable drug carrier to increase the effectiveness of the fixed combination of Timolol maleate and Brimonidine tartrate and be proposed as a new drug formulation for targeted and controlled drug delivery in the treatment of glaucoma.
Effect of different weekly frequencies of Chen-style Tai Chi in elders with chronic non-specific low back pain: Study protocol for a randomised controlled trial
Authors: Wan Ruihan , Shi Jian , Wang Yafei , Hu Kun , Jiang Xue , Yan Wangwang , Cao Mali , Wang Yuling 
Published: September 2022

Abstract
Background: Tai Chi (TC), as one of mild to moderate exercise therapies specifically recommended by multiple clinical guidelines, is a viable option for chronic non-specific low back pain (CNLBP) treatment. Nevertheless, limited studies focused on the effect of different weekly frequencies of TC in elders with CNLBP. This study aims to compare the differences of TC with different weekly frequencies in elders with CNLBP on the premise of proving its effectiveness, and to identify whether mindfulness mediates the effect of TC on treatment outcomes.
Methods: Totally 148 senior citizens aged 60 years old or above with CNLBP (as defined by the National Institutes of Health criteria) will be recruited in this single-centre, randomised, single-blinded, parallel controlled trial and conducted in the Sports Centre of Changsha First Social Welfare Institute, Hunan Province, China. Participants will be randomly divided into four groups: three different weekly frequencies Chen-style TC groups (1, 3, and 5 sessions/week, 60min/session, sustain for 12weeks on the basis of weekly health educational lecture), whereas the control group will only undergoweekly healthy educational lecture. Three months of follow-up visits will be conducted. The primary outcome is pain intensity, which will be measured at baseline, after every four weeksof intervention, and after the follow-up period via Visual Analogue Scale (VAS). Secondary outcomes include Beck Depression Inventory-II (BDI-II), Pain Catastrophising Scale (PCS) and Five Facet Mindfulness Questionnaire (FFMQ), Oswestry Disability Index (ODI), and Short Form-36 (SF-36), which will be measured before and after intervention and after the follow-up period. The intention-to-treat and per-protocol principles will be used to analyse primary and secondary outcomes with a setting at α = 0.05 as statistical significance.
Discussion: This comprehensive and detailed protocol will be the first trial to compare the effectiveness of different weekly frequencies of TC in elders with CNLBP. The outcomes may provide valuable data about the choice of ideal number of sessions to further normalise the application of exercise for clinicians.
Trial registration: Chinese clinical trial registry, ChiCTR2200058190, Registered on 1 April 2022. http://www.chictr.org.cn/showproj.aspx?proj=162729.
Different approaches for the treatment of myopic choroidal neovascular: a network meta-analysis
Authors: Wu Yajun , Feng Yuliang , Yang Jiasong , Fan Hua , Yu Zitong , Xie Xiaolin , Dai Yumeng , Li Wensheng 
Published: September 2022

Abstract
Purpose: In order to evaluate the efficacy of intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs, photodynamic therapy (PDT), and laser treatment (LT) for anatomical and functional improvement in myopic choroidal neovascularization (mCNV) patients were evaluated in a mesh meta-analysis.
Methods: Two researchers independently searched PubMed, Cochrane Library, Web of Science, CNKI, WanFang Data, Embase, and other databases to screen RCTs and retrospective studies comparing best-corrected visual acuity (BCVA) and foveal center thickness (FCT) changes after mCNV treatment. The retrieval time limit is from the database construction to November 30, 2021. ADDIS1.16.8 and R 3.5.3 software were used to conduct mesh meta-analyses of RCTs and retrospective studies, respectively.
Results: A total of 601 eyes in 8 RCTs involving 6 treatment options: intravitreal bevacizumab (IVB), intravitreal ranibizumab (IVR), intravitreal conbercept (IVC), intravitreal aflibercept (IVA), LT, PDT, sham first followed by IVA (Sham /IVA). The results of the mesh meta-analysis showed that: in the RCTs, IVB and IVR were superior to PDT [MD=0.18, 95%CI (0.01, 0.42)] in improving BCVA of mCNV patients, and all the therapeutic effects from high to low might be intravitreal IVA, IVB, IVR, LT, Sham/IVA, and PDT; the order of FCT thickness reduction from high to low is IVA, IVR, IVB, PDT. In addition, the results of BCVA after long-term treatment in retrospective studies showed that all the therapeutic effects from high to low might be IVA, IVC, IVB /IVR, IVB, IVR, PDT, PDT with IVB /IVR; as for the order of FCT thickness reduction from high to low is IVA, IVC, IVR, IVB, PDT.
Conclusions: Anti-VEGF treatment in patients with long-term improvement in mCNV vision effect is best, using IVB or IVR alone to treat mCNV may be better than IVB or IVR combined with PDT; There was no significant difference in the improvement of visual acuity and macular edema in mCNV patients with different anti-VEGF drugs. Due to the limited number and quality of included literature, the above conclusions need to be confirmed by more large-sample and high-quality articles.