bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability Indicating Method Development and Validation for Assay of Omeprazole Sodium for Injection by a Rapid RP-HPLC
Authors: Dande Aishwarya , Reddy Gummadi Rishitha , Saithya Gaddam Saithya 
Published: March 2022

Omeprazole,13 a member of proton pump inhibitor, used for the treatment of peptic ulcers, it supresses gastric acid secretion by inhibiting H+/K+ ATPase. A new fundamental, rapid and sensitive HPLC method was developed for the assay of Omeprazole sodium for injection. It was validated according to ICH and FDA guidelines 2. The HPLC analysis was performed on Dionex ultimate 3000 system equipped with C-18 (150cm*4.6mm) 5µ column, with a mixture of ammonium acetate and acetonitrile buffer in the ratio 65:35 v/v as the mobile phase at the wavelength (λ) 305nm. The total run time was 8 minutes. The calibration curve was linear for 50-150% range of the analytical concentration of 40mg/ml, r2 was found to be 0.9998. The precision was calculated and % RSD was 0.1 % and the recovery of omeprazole was within the range of 98-102%. Validation parameters like robustness, solution stability studies, specificity and forced degradation studies were performed and found to be within acceptance limits. As compared to other methods, this method was found to be more accurate, linear, precise and specific, with short run time. All the results were acceptable and confirmed that the method is suitable for its intended use in routine quality control analysis.
Antibacterial Activity Test of Ethanol Extract From Unripe Klutuk Banana Fruit (Musa Balbisiana Colla Bb) Towards Bacterial Of Staphylococcus Aureus And Escherichia Coli
Authors: M Misrahanum , Depi Ririn Edra , Helwati Hira 
Published: March 2022

Object : This study aims to look at antibacterial activity Ethanol extracts from the flesh and peel of unripe klutuk banana fruit (Musa balbisiana Colla BB) against Staphylococcus aureus and Escherichia coli.
Methods : Study included phytochemical screening, simplicial and extract characterization, antibacterial testing using a well diffusion method ethanol extracts from the flesh and peel of unripe klutuk banana fruit (Musa balbisiana Colla BB) against Staphylococcus aureus and Escherichia coli.
Results : The phytochemical test showed that both extracts contained alkaloid compounds, flavonoids, tannins, triterpenoids, and saponins. The fruit simplicial characterization of the flesh and peel contains 5% and 7.17% of water level; 14.55% and 11.61% of total ash level; 10.67% and 9.67% of water-soluble level; 9.67% and 9.67% of ethanol-soluble level. The ethanol extracts of the flesh and peel of unripe klutuk banana contains water level of 28.26% and 15.5%;total ash level of 10.16% and 14.09%; water-soluble level of 33.33% and 71.67%, and ethanol-soluble level of 69.16% and 78.33%. The highest activity of the peel ethanol extract towards S. aureus was obtained at 10% concentration with an inhibiting zone diameter of 9.3 mm and the highest activity of the flesh ethanol extract towards E. coli was obtained at 20% concentration with an inhibiting zone diameter of 8.63 mm.
Conclusion : Antibacterial activity against S. aureus by the ethanol extract from the peel was higher than ethanol extract from the flesh of the fruit. While antibacterial activity towards bacterial E. coli by the flesh of fruit showed better activity.
Preparation and Characterization of Different Types of Extruders and Its Techniques
Authors: Ogale Nikita , Kamble Komal 
Published: March 2022

The study on characterization of different types of extruder such as single screw cone type, axial type extruder, radial type extruder, die roller type extruder from excipient, enzyme and silica has been performed. The primary goal of the project focuses on making pellets from MCC+LACTOSE, MCC+STARCH, Enzyme and Silica. The process is extremely encouraged in several pharmaceutical industries. The below article will help us understand various aspects of techniques used in the extrusion of pellets. The extruder process of pellets are mainly mixing and extrusion. We will also discuss about the several factors that might influence the pellet quality which includes formulation - granulating liquid, excipients; Equipment (Rapid mixer granulator, various type of extruder, and size of extrusion screen) and process (Extrusion speed, extrusion time). The characterization of the pellets includes estimation of various parameters such as moisture content ,appearance, shape , bulk density, disintegration of the pellets are explained.
Randomized, open-label, two-way crossover bioequivalence study of Novirax (Drug International Ltd, Bangladesh) compared with Zovirax (Glaxo Wellcome, UK) – two brands of Acyclovir – in healthy male volunteers
Authors: Sarker Uttam Kumar , Hossain Mezbah , Islam Md. Atikul , Shamsuzzoha Md. , Najim Uddin Md. , Misbahuddin Mir , Mollah Md. Elias , Islam Md. Rabiul 
Published: March 2022

Objectives: A crossover-randomized bioequivalence study of two oral formulations of acyclovir 200 mg tablet was accomplished with 16 adults and physically fit male volunteers from Bangladesh. NOVIRAX™ (Drug International Ltd, Bangladesh) was the test variant whereas ZOVIRAX™ (GlaxoWellcome) was the reference one.
Methods: After a night fasting each volunteer was subjected to take a single dosage of tablet with 150 mL of water. After a week for complete washing out, a second dosage was applied. After that, blood samples were collected at a serial interval for a 24 hours period to observe the plasma concentration by HPLC technique. Several pharmacokinetic parameters like Cmax, Tmax, AUC0→24h, t1/2, and Kel were estimated.
Results: The mean (± SD) AUC0→24h for acyclovir of test variant NOVIRAXTM for 16 participants was 1057.5 ± 358.9 ng/hr/mL whereas it was 1134.9 ± 467.2 ng/hr/mL for acyclovir of ZOVIRAXTM. The relative bioavailability (NOVIRAXTM/ZOVIRAXTM ratio) was 93.2%. The Cmax, tmax, half-life of elimination (t1/2) and the rate of elimination (Kel) of acyclovir of test drug were 207.0 ± 86.9 ng/mL, 2.4 ± 0.4 hours, 3.2 ± 1.8 hour and 0.0898 respectively. The Cmax, tmax, half-life of elimination (t1/2) and the rate of elimination (Kel) of acyclovir of reference drug were 230.7 ± 107.2 ng/mL, 2.0 ± 0.9 hours, 2.8 ± 1.2 hour and 0.0921 respectively.
Conclusion: Depend on these statistical speculations; it was culminated that a NOVIRAX tablet is bioequivalent to a ZOVIRAX tablet.
Modulation of immune mechanisms during hepatoprotective effects of Dawa-Ul-Kurkum, a Unani polyherbal preparation in experimental model of paracetamol induced liver damage in rats
Authors: Rafi Reshi Mohd , Kavita Gulati , Arunabha Ray 
Published: March 2022

Objective: Iimmunomodulatory effects of Dawa-Ul-Kurkum, a Unani polyherbal preparation and the possible mechanisms in experimental model of paracetamol induced liver damage in rats.
Materials and methods: The drug Dawa-Ul- Kurkum has been prepared and provided by CRIUM, Hyderabad. Silymarin was purchased from Sigma-Aldrich (USA) and paracetamol (marketed by Cipla LTD) purchased from general pharmacy shop. Biochemical kits were purchased from ERBA Diagonostic Mannheim Gmbh. Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST) and serum alkaline phosphatase (ALP) were estimated by Kinetic method of International Federation of Clinical Chemistry (IFCC), serum bilirubin and total protein were estimated by End Point assay as per the instruction of the Kit Manufacture’s manual.Immunoglobulin and cytokine levels were assessed by ELISA kit manual method. Delayed type hypersensitivity reaction by Institoris et al method. Lipid peroxidation is measured spectrophotometrically as 2-thiobarbituric acid-reactive substance (TBARS), Glutathione (GSH) levels were estimated by the method of Ellman and NOx concentrations were determined by using the Griess reaction as described previously by Tracey et al.
Results: Liver damage was induced in Wistar rats by administration of paracetamol and the effects of various drug treatments were assessed on morphological, biochemical, immunoglobulin, cytokine level and histological markers of liver toxicity. In the vehicle treated experimental group, administration of paracetamol induced significant derangements in liver function as evidenced by increased levels of SGOT, SGPT, alkaline phosphatase bilirubin and decrease in total protein, and reductions in body weight and increased liver weights as compared to controls. Histopathological examination showed Periportal necrosis with haemorrhages in experimental control. Pretreatment with Dawa-Ul-Kurkum (DK, 250 and 500 mg/kg) and hydroalcoholic extract of DK (HA, 500 and 1000 mg/kg) showed protective effects against the paracetamol induced biochemical, immunoglobulin, cytokine, delayed type hypersensitivity reaction and histopathological derangements of liver function following paracetamol. Conclusion: Both DK and its 50% hydro-alcoholic extract were found to be effective against paracetamol induced liver damage as they significantly prevented the hepatotoxic damage induced in rats.
Evaluation of Anti-hyperlipidemic Activity of Red Onion In Experimental Animals
Authors: Kadam Pooja , Chaware Vitthal , Redasani Vivek 
Published: March 2022

Objective: To evaluate antihyperlipidemic effect of red onion on poloxamer 407 induced hyperlipidemia in wistar albino rats.
Methods: Hyperlipidemia was induced by intraperitoneal injection of poloxamer-407 (P-407) at a dose of 1.0g/kg body weight in wistar albino rats. Drug treatments were done by oral gavage for 21 days. At the end of the study, animals were kept fasted over night and then blood samples were collected. The serum total cholesterol (TC), triglycerides (TG), and High density lipoprotein (HDL) were measured while low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were calculated by Friedewald formula and atherogenic index was also calculated.
Results: From the present investigation, it was observed that ethanolic extract of red onion have shown significant reduction in serum cholesterol, triglyceride and lipoprotein levels and increase in HDL level in P-407 induced hyperlipidemia.
Conclusion: The findings in this study revealed the effectiveness of ethanolic extract of red onion against hyperlipidemic activity.
Potential of Piperaceae Plants as Antibacterial against Staphylococcus aureus and Escherichia coli: A Review
Authors: Magdalena Hottria , Fajrina Anzharni , Eriadi Aried , Asra Ridho 
Published: March 2022

Background: Infectious disease was one of the most common health problems in developing countries which are caused by microorganism, such as bacteria. Piper (Piperaceae) was a medicinal plant that has potential as an antibacterial. Some plants of the piperaceae family have antibacterial activity against Escherichia coli and Staphylococcus aureus, such as Piper cubeba, Piper nigrum, Piper betle, Piper crocatum, Piperomia pellucida, Piper longum, Piper sarmentosum, and Piper aduncum.
Purpose: This article described plant of the Piperaceae family that has antibacterial potential. This article reviewed the study of the antibacterial potential of the Piperaceae plant from various articles.
Data source: The database sources used include Google Scholar, Science Direct, and Media Published from 2010 to 2021.
Conclusion: It carried out by reviewing several libraries such as indexed national journals, international journals, and scientific articles regarding the potential of the Piperaceae plants as antibacterial against Staphylococcus aureus and Escherichia coli. The antibacterial activity of the Piperaceae plant originated from secondary metabolites of these plants including alkaloids, tannins, saponins, phenolic compounds, and flavonoids.
PENERAPAN PERMAINAN KOLABORATIF DALAM MENINGKATKAN ASPEK SOSIAL PADA ANAK USIA DINI
Authors: Suniarti Petty , Nuraeni Lenny 
Published: March 2022

Efforts to improve social aspects in early childhood by implementing collaborative games, to be able to improve social skills in children in group A, the role of teachers and parents are very much needed. To be able to provide a stimulus for social skills in children, it can be done through several collaborative games through games, including the traditional sondah game. This study uses a qualitative descriptive research method that aims to determine efforts to improve social aspects through the application of collaborative games. Data collection techniques using observation, interviews. Data analysis is based on the results of observations of initial activities or before being given stimulation, during and after getting stimulation. Researchers research the field through a reduction in presenting data. The results showed that the application of collaborative games through traditional sondah games could improve the social aspects of early childhood. This study concludes that traditional sondah games as part of collaborative games, can improve aspects of early childhood social development.Upaya meningkatkan aspek sosial pada anak usia dini dengan melakukan penerapan permainan kolaboratif,untuk dapat meningkatkan kemampuan sosial pada anak di kelompok A sangat diperlukan peran guru dan orang tua. Untuk dapat memberikan stimuluskemampuan sosialnya pada anak dapat melalui beberapa permainan kolaboratif melalui permainan, diantaranya permainan tradisional sondah.metode penelitian deskriftif kualitatif yang bertujuan untuk mengetahui upaya peningkatan aspek social melalui penerapan permainan kolaboratif dijadikan pada metode penelitian ini. Subjek penelitian ini terdapat 8 peserta didik yang terdiri dari 3 orang anak laki laki dan 5 orang anak perempuan di PAUD Al Ikhlas. Teknik pengumpulan data ini menggunakan observasi, wawancara. Hasil dari tekhnik pengumpulan data dianalisis dengan analisis data kualitatif. Setelah penelitian ini dilakukan maka diperoleh hasil penelitian menunjukkan penerapan permainan kolaboratif melalui permainan tradisional sondah dapat meningkatkan aspek social anak usia dini. Kesimpulan penelitian ini adalah melalui permainan tradisional sondah bagian dari permainan kolaboratif mampu meningkatkan aspek perkembangan sosial anak usia dini.
STIMULASI KECERDASAN SOSIAL EMOSIONAL ANAK MELALUI PENDEKATAN STEAM DI KOBER AL BANA
Authors: Handayani Tuti , Jumiatin Dedah 
Published: March 2022

Early Childhood is a child who has a very high curiosity, in addition to a very high sense of curiosity, children always have the desire to try various ways to help themselves when facing problems in their daily environment. One of the intelligence of children that must be developed is emotional-social intelligence. One method that can be used to develop children's emotional-social intelligence is through the STEAM (Science, Technology, Engineering, and Mathematics) approach with the STEAM approach. In Kober Al Bana, it can be seen that children's social-emotional intelligence is still low, especially in group A due to lack of stimulus, teachers play more in the room, therefore this study aims to improve children's emotional-social intelligence with the STEAM approach. The technique of this research is observation with qualitative data analysis. Subjects that the researchers took were 10 children, namely 5 girls and 5 boys. To stimulate the emotional-social intelligence of the children, the researchers used the game of taking the ball in groups outside the room. With these play activities, the researchers got the final result of 90% of children's social-emotional increase.Anak Usia Dini sesungguhnya anak yang memiliki rasa ingin tahu yang sangat tinggi, disamping rasa kaingin tahuannya yang sangat tinggi anakpun selalu mempunyai keinginan mencoba berbagai cara untuk menolong dirinya sendiri ketika menghadapi masalah dalam lingkungannya sehari-hari. Salah satu kecerdasan anak yang harus dikembangkan yaitu kecerdasan sosial emosional. Salah satu metode yang dapat digunakan untuk mengembangkan kecerdasan sosial emosional anak yaitu melalui pendekatan STEAM (Science, Technology, Engineering and Mathematics)dengan pendekatan STEAM bisa dilakukan dengan cara bermain salah satunya adalah dengan permainan ambil bola secara berkelompok. Di Kober Al Bana terlihat kecerdasan sosial emosional anak masih rendah khususnya kelompok A karena kurangnya stimulus, guru bermain lebih banyak didalam ruangan, oleh karena itu penelitian ini bertujuan untuk meningkatkan kecerdasan sosial emosional anak dengan pendekatan STEAM. Teknik penelitian ini adalah observasi dengan analisis data kualitatif Subjeg yang peneliti ambil berjumlah 10 anak yaitu 5 anak perempuan dan 5 anak laki-laki, Untuk menstimulus kecerdasan sosial emosional anak peneliti menggunakan permainan ambil bola secara berkelompok di luar ruangan. Dengan kegiatan bermain tersebut peneliti mendapatkan hasil akhir 90% sosial emosional anak meningkat.
Pelatihan Empati Pada Anak Kelas V SD Antonius 2 Banyumanik Kota Semarang
Authors: Sumijati Sri , Suparmi Suparmi 
Published: March 2022

Empati merupakan kemampuan yang sangat penting bagi relasi sosial yang baik, sehingga latihan empati harus diberikan kepada individu sejak masih kecil. Pengabdian masyarakat berupa pelatihan empati ini dilakukan terhadap kelompok sasaran, yaitu siswa kelas V SD Antonius 2, Banyumanik, Kota Semarang. Adapun tujuan pelatihan adalah untuk meningkatkan empati anak-anak tersebut. Sebanyak enambelas anak berpartisipasi dalam pelatihan, terdiri dari sebelas anak perempuan dan lima anak laki-laki dengan rentang usia 10 tahun 3 bulan – 11 tahun 11 bulan. Pelatihan dilakukan dalam empat sesi, dimana setiap sesi berlangsung selama 90 menit. Metode yang digunakan dalam pelatihan adalah mengajak anak berdiskusi tentang pengertian empati dan macam-macam emosi, menunjukkan video-gambar-foto dan membahasnya bersama anak, membaca cerita dan mendorong anak untuk bertanya atau berkomentar, meminta anak untuk menggambar dan berceritera tentang gambarnya, memberi tugas yang harus dikerjakan anak di rumah. Pelaksanaan pengabdian masyarakat ini berlangsung selama bulan Februari hingga Maret 2020, dan hasilnya menunjukkan bahwa secara kuantitatif tidak ada peningkatan empati pada anak-anak yang mengikuti pelatihan empati. Hal ini nampak dari tidak adanya perbedaan empati yang diukur sebelum dan setelah pelatihan. Meskipun demikian secara kualitatif ada indikasi peningkatan perilaku empatik yang muncul dalam interaksi anak dengan orang lain.
Penyuluhan Dan Konsultasi Hukum Bagi Guru-Guru Anggota Pgri Kabupaten Karanganyar Provinsi Jawa Tengah
Authors: Pratama Toebagus Galang Windi , Budoyo Sapto , Widodo Wahyu , Maryanto Maryanto 
Published: March 2022

Perlindungan Hukum bagi guru di dalam menjalankan tugas profesional nya amat diperlukan mengingat banyak nya kasus baik pidana maupun perdata yang seringkali menimpa guru. Hal ini menjadi dasar bagi tim pengabdi di dalam melakukan pengabdian dalam bentuk Penyuluhan dan Konsultasi Hukum Bagi Guru-Guru Anggota PGRI Kabupaten Karanganyar Provinsi Jawa Tengah. Metode Pelaksanaan Pengabdian ini direncanakan dibagi menjadi 4 Tahapan yakni Penyuluhan terkait Tugas Profesional Guru yang telah dilaksanakan pada hari Jumat, 09 April 2021 yang dilanjutkan dengan Konsultasi hukum Bagi Guru-Guru Anggota PGRI Kabupaten Karanganyar Provinsi Jawa Tengah dimana metode pelaksanaan nya ialah dengan Konsultasi Langsung di Jadwal yang sudah ditentukan selama periode 09 April 2021 hingga 09 Juni 2021 dan Konsultasi tidak langsung secara Online yang kemudian diakhiri dengan kegiatan monitoring dan Evaluasi. Terhadap pelaksanaan program pengabdian ini, telah mendapat reaksi yang positif dari guru guru anggota PGRI Kabupaten Karanganyar sebagaimana dapat dilihat dari banyaknya peserta yang hadir dan jumlah guru yang melakukan konsultasi. Target luaran dari kegiatan pengabdian ini yang sudah tercapai ialah meningkat nya pemahaman Guru-Guru Anggota PGRI Kabupaten Karanganyar Provinsi Jawa dan publikasi pada media massa.
Formation of Early Dissident Movements Ideology in USSR in 1960s Years: Ethics of Alexander Yesenin-Volpin
Authors: Gross A. A. 
Published: March 2022

The problem of the appearance of the Soviet dissident movement in 1965 is investigated. Particular attention is paid to the “Glasnost rally” on December 5, 1965, which, according to the recollections of the dissidents themselves, became the “assembly point” of the movement. The novelty of the research lies in the fact that the author offers an interpretation of the moral motives of the initiator of the rally, Alexander Yesenin-Volpin. The main sources of the study are the unpublished diaries of 1961—1965 and the political statement of Yesenin-Volpin in August 1965, kept in the archives of the International Memorial in Moscow. Particular attention is paid to the case of the publication of the “letter of repentance” by the well-known Moscow dissenter Alexander Ginzburg in the newspaper “Vechernyaya Moskva” in June 1965; it had not previously attracted the attention of researchers. It is shown that, having condemned the “repentance” of a dissenter in a political statement in August 1965, Yesenin-Volpin formulated a “dissident” ethic known in the late 1960s — early 1970s. It has been proven that the statement summed up the dissident’s moral reflections in his diaries and became the source of the slogans with which Yesenin-Volpin was preparing for the «Glasnost Rally». As a result of the study, the author comes to the conclusion that in the summer of 1965 in the imagination of the dissident there was already a social community united by “dissident” values.
Use of Dynamic Time Warping for Description of Combustion Process in a Biomass Boiler
Authors: Kucín Martin , Fajman Martin , Polcar Adam , Čupera Jiří 
Published: March 2022

Abstract
The efficient biomass energy use is a key prerequisite for the implementation of renewable energy development strategies on a regional level. For the highly efficient energy use in the combustion process, it is necessary to properly regulate the process based on its precise description. The paper aim is to evaluate whether dynamic time warping (DTW) methods can be used for this description, as well as for the recognition of the specific operating state of a biomass boiler. For the DTW analysis, operating records of more than 10 hours of a laboratory biomass boiler (P = 25 kW) were used, including an emission analysis, for which the operating modes were intentionally alternated in order to identify the stable and transient states of boiler operation. Based on the results, it can be stated that the identical partial operating sections of the controlled variables can be reliably identified in the operating variables of boiler by means of the DTW method, since its manifestations of operating regulation showed compliance with the given operating state, and it is possible to identify a partial quantity for estimating the total operating boiler state.