bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Sentiment Analysis of Textual Feedback in the Student-Faculty Evaluation using Machine Learning Techniques
Authors: Pacol Caren A. , Palaoag Thelma D. 
Published: August 2022

Sentiment Analysis has been an interesting and popular research area encouraging researchers and practitioners to adopt this tool in various fields such as the government, health care and education. In education, instruction evaluation is one of the activities that sentiment analysis has served. Though, it is a common practice that educational institutions periodically evaluate their teachers’ performance, students’ comments which are rich in insights are not easily taken into account because of lack of automated text analytics methods. In this study, supervised machine learning algorithms were used. Experiments were conducted to evaluate base models employing naïve bayes, support vector machines and logistic regression in comparison to ensemble combining the three. Random forest, an ensemble learning algorithm was also experimented. Machine learning techniques such as term-frequency – inverse document frequency (TF-IDF) and ngram were also explored to devise a model with the highest possible accuracy. Results show that in this case, tf-idf vectorization does not show significant improvement in sentiment classification. On the other hand, ngram vectorization improve performance of base models and has potential to improve ensemble models. Random forest showed higher performance measures than base models and ensemble of the three base models. However, it did not outperform ngram combined with support vector machines. In future work the model with highest accuracy found can be embedded in a sentiment analysis tool for students’ feedback on teaching performance. More advanced transformation techniques and other ensemble techniques may be explored to further improve accuracy in sentiment classification.
Mine water chemistry development in the R3 shaft of the Rozna I uranium mine, Czech Republic
Authors: Vokurka Michal , Mertová Lenka , Žilová Patricie 
Published: August 2022

The paper describes the current non-mining state of the Rozna I uranium mine which is located in the central part of the Czech Republic. The subject is a 1 200 m deep R3 shaft which is excavated from the surface. At the R3 shaft is carried out regular monitoring of mine water, specifically inflows to the deposit and their chemistry. Chemical monitoring is carried out by proper collection of mine water and their consequent chemical analysis in an accredited laboratory.
The results of the chemical analysis were processed using standard text and spreadsheet editors and using geochemical modeling software. The paper defines several types of water with slightly different chemistry, but the majority is calcium sulphate type of mine water. Occasional fluctuations in mine water concentrations were not dependent on the concentration of extraction, because at the R3 shaft was extraction of uranium ore terminated in 1996. Fluctuations are attributed only to technological interventions of maintenance work on the shaft. The development of chemistry of mine water was described at the shaft during the years 1994 – 2019. The mine water from the R3 shaft were analyzed for the saturation index. Minerals which could precipitate under specific conditions in the form of amorphous precipitates, coatings or other precipitates, were described.
Soil Loss Estimation within the Nun River Basin using Revised Universal Soil Loss Equation (RUSLE) integrated in Geographic Information Systems (GIS)
Authors: Ehiorobo Jacob , Ilaboya Rudolph Idowu , Onwo Nelson 
Published: August 2022

River bank erosion can cause undesired river bank expansion, distortion of the river course thereby slowing the river velocity and hindering the water carrying capacity of the river. Slow velocity of the river course can result in fast sediment accretion and accumulation at the bottom of the river. If these trends are not checked, the river may wind down and at best begin to become a delta at its middle course. The focus of this study is to apply GIS and analytical RUSLE equation to estimate soil loss within the Nun Basin.
Core sediment samples were collected from relatively undisturbed areas (nine different stations) using Uwitec Triple sediment cutter. The sediment samples were processed in the lab for sediment particle size analysis (PSA) and Pb-210 atmospheric deposition with age using alpha spectrophotometer. Spatial rainfall data of the study location were employed to generate the rainfall erosivity map in order to determine the erosivity factor (R). Particle size distribution analysis was validated using Scanning Electron Micrograph (SEM) and integrated with Geographic Information Systems (GIS) was employed to create the soil erodibility map which was subsequently used to determine the erodibility factor (K). The cover management factor (P) was determined using the land use land cover map and the resulting data were then employed to model the river bank erosion around the study area.
Result of the study revealed that the maximum annual average soil loss rate was estimated to be 0.66 tons/ha. /year around the Nun River based on GIS application using the Revised Universal Soil Loss Equation (RUSLE).
The Characteristics and Health Problems of International Tourists who Visited Sanglah General Hospital between 2017 and 2019
Authors: Utama I Made Susila , Purnamasidhi Cokorda Agung Wahyu , Sukmawati Ni Made Dewi Dian , Gayatri Anak Agung Ayu Yuli , Somia I Ketut Agus , Merati Tuti Parwati , Dwipayana Gede Arya , Janardhana Gus De 
Published: August 2022

Travel Medicine is one branch of medicine which specializes in preventing and treating medical problems for travelers especially when they are traveling. It is undeniable that there are differences in medical knowledge between developing and developed countries when dealing with traveler’s health problems. The purpose of this study is to comprehend the characteristics and health problems of travelers who visited Sanglah General Hospital between 2017 and 2019. This is a descriptive study which used consecutive sampling in every medical record of the patients to study their health problems. Every medical record recorded the name, age, sex, health insurance, inpatient or outpatient, and diagnosis of the patients. As many as 618 subjects’ medical record number was conducted at first with dominantly men (55.2%) and women (44.8%). The mean age of this study was 42,76 years old with the eldest age being 92 years old and the youngest being 18 years old. As many as 328 subjects (53.1%) of this study did not use health insurance and only 290 subjects (46.9%) used health insurance. The number of outpatients, which was 564 subjects (91.3%), was much more than the number of inpatients in this study. Frequent health problems that subjects suffered were malignancy (solid and hematologic) 116 subjects (18.7%), kidney problem 107 subjects (17.3%), and accident (wounds, fracture and head trauma) 44 subjects (7.1%). Descriptive study among travelers is not usually done in our hospital and this is an elementary study so that in the future there will be more study for travelers.Keywords: Travel medicine; Travel; Tourism.
Perfil dos enfermeiros que atuam nas Unidades de Saúde da Família e a qualidade da assistência prestada
Authors: Pontes Alice Fonseca , Estelita Rafaela Ribeiro de Oliveira , Sousa Giovanna Barreto de , Paixão Talita Bianca Lima da , Santos Amanda Monteiro dos , Gomes Júnior Alan de Oliveira , Araújo Sanmyra Lopes , Lima Maria Eduarda Ximenes do Rego , Rodrigues Natália Almeida , Andrade Ângela Roberta Lessa de 
Published: August 2022

O presente estudo é de cunho quantitativo realizado com enfermeiros que cuidam de Unidades de Saúde da Família (USF), no município de Olinda, Pernambuco, Brasil. Esse trabalho tem como objetivo verificar o perfil dos enfermeiros e a qualidade da assistência prestada por eles. Os dados foram coletados por meio de um questionário semiestruturado, onde na análise constatou-se que todos os enfermeiros entrevistados estavam na faixa etária de 20 a 40 anos; a maior parte desses profissionais eram mulheres, casadas, e tinham mais de 3 anos de atuação na assistência de enfermagem. Ademais, a maioria não possui pós-graduação no Programa de Saúde da Família (PSF), e dizem não ter segurança na realização dos procedimentos, e acreditam que a estratégia do PSF é bem desenhada, mas mal implementada. O presente estudo permitiu conhecer melhor o perfil desse tipo de profissional e a qualidade do trabalho que prestam nas equipes de saúde da família.
Eco-friendly production of thermostable, halotolerant and pH wide range biosurfactant by Issatchenkia orientalis UCP 1603
Authors: Fonseca Tainã Crisia de Souza , Rodriguez Dayana Montero , Mendonça Rafael de Souza , Ferreira Isabela Natália da Silva , Costa Luiz Oliveira , Campos-Takaki Galba Maria 
Published: August 2022

Microbial surfactants are amphiphilic molecules with attractive industrial prospects due to their advantages over commonly commercialized chemical surfactants, such as low toxicity, high biocompatibility and biodegradability, and efficiency at extreme conditions. However, the large-scale production of biosurfactants still becomes uncompetitive due to the low yields and onerous costs, being considered the use of renewable substrates as a viable strategy. In this sense, the present study aimed to investigate the sustainable production of biosurfactant by the yeast Issatchenkia orientalis UCP 1603 in 2 L of salt-based medium supplemented with 7.5% cassava wastewater, 5% corn steep liquor and 1% post-frying soybean oil. Fermentation was carried out in 2.8 L-Fernbach flasks for 72 h, at 28°C and 150 rpm, and reduction in surface tension to 30.1 mN/m was verified. The highest yield of the biosurfactant produced (4.02 g/L) was observed after extraction with 70% ethanol (2:1, v/v) and the isolated biosurfactant reduced the surface tension of the medium to 28.7 mN/m, the interfacial tension against n-hexadecane to 16.6 mN/m and has a CMC of 800 mg/L. The biocompound showed anionic and polymeric nature and did not present toxicity against cabbage (Brassica oleracea var. capitata) seeds. The stability in the range of pH 4-10, salinity 5-25% and temperature 5-100°C, evidenced a highly stable biosurfactant, with promising potential of application in several industrial activities or environmental processes in adverse conditions.
MAKNA SIMBOLIS TRADISI SEDEKAH LAUT LONGKANGAN DI PANTAI BLADO KECAMATAN MUNJUNGAN, KABUPATEN TRENGGALEK
Authors: Palanjuta Nandiata Ayu , Ruja I Nyoman 
Published: August 2022

Sedekah Laut (Coastal Thanksgiving) is a tradition inherent to coastal communities or fishermen in Indonesia. The implementation of Sedekah Laut has a characteristic difference, both from ritual addressing to implementation. Although sea charity has the same purpose - as a means of giving thanks to God Almighty for the blessings that have been given- Munjungan people also has a Sedekah Laut tradition commonly called the Longkangan traditional ceremony. This tradition is routinely held annually in the month of Dzulkaidah on the Hijri or Sela calendar on the Javanese calendar. The implementation of tradition has a procession and symbolic meaning. This research aims to describe and analyze the implementation process and the meaning of Longkangan Ceremony tradition. This research used descriptive qualitative research methods with data collection techniques consisting of observation; interview; and documentation. Triangulation technique was also used to analyze the data that has been collected to obtain the validity of data according to the theory of symbolic interactionism according to George Herbert Mead and the concept of customary ceremonies according to Koentjaningrat. The results of study are the stages of Longkangan traditional ceremonies held twice in one day, the procession of Labuh Laut by Tumpeng Agung in the morning followed by officials and the Muspika (District-Level Executive Conference) as the patron of Munjungan District and the core ceremony at night followed by guests Breng Kidul. Each stage of this tradition procession also has a specific symbolic meaning. Hopefully, the historical manuscript of Longkangan traditional ceremonies can be recorded and can be studied by the younger generation, especially the Munjungan community.
Intracoronary artery retrograde thrombolysis for ST-segment elevation myocardial infarction with a tortuous coronary artery: A case report and review of the literature
Authors: Shen Mingzhi , Lu Haihui , Liao Yichao , Wang Jian , Guo Yi , Zhou Xinger , Nong Yingqiao , Fu Zhenhong , Wang Jihang , Guo Yuting , Zhao Shihao , Fan Li , Tian Jinwen 
Published: August 2022

BackgroundHow to deal with large thrombus burdens of culprit’s blood vessel remains a great challenge in the treatment of acute myocardial infarction.Case presentationA 32-year-old Chinese man was diagnosed with ST-segment elevation myocardial infarction (STEMI). Coronary angiography revealed that the distal end of a tortuous left circumflex was completely occluded by a large amount of thrombus. Cutted balloon-directed intracoronary artery retrograde thrombolysis (ICART) with urokinase led to the restoration of coronary blood flow. Because there was no obvious plaque rupture or artery stenosis in the coronary artery, it was only dilated, and no stent was implanted.ConclusionCutted balloon-directed ICART can be performed effectively and safely in some STEMI patients with tortuous coronary vessels and large thrombus. (REST or named ICART ClinicalTrials.gov number, ChiCTR1900023849).
Telotristat ethyl reverses myxomatous changes in mice mitral valves
Authors: Wang Xinmei , Kuban-Johnston Danielle , Lapuerta Pablo , Lacerda Carla M. R. 
Published: August 2022

RationaleMyxomatous mitral valve degeneration is a common pathological manifestation of mitral valve regurgitation, with or without valvular prolapse. In addition to similarities between naturally occurring and serotonergic valve degeneration, an increasing body of evidence has recently suggested that serotonin signaling is a regulator of degenerative valvulopathies. Studies have found that serotonin can be synthesized locally by valvular cells and serotonin receptors in turn may be activated to promote signaling. Recently, telotristat ethyl (TE) has been introduced as a treatment for carcinoid disease, by selectively inhibiting tryptophan hydroxylase 1, the rate-limiting enzyme in peripheral serotonin synthesis. TE provides a unique tool to test inhibition of serotonin synthesis in vivo, without impacting brain serotonin, to further confirm the role of local serotonin synthesis on heart valves.ObjectiveTo confirm the link between serotonin and myxomatous valvular disease in vivo.Methods and resultsA hypertension-induced myxomatous mitral valve disease mouse model was employed to test the effect of TE on valvular degeneration. Circulating serotonin and local serotonin in valve tissues were tested by enzyme immunoassay and immunohistochemistry, respectively. TE was administrated in two modes: (1) parallel with angiotensin II (A2); (2) post A2 treatment. Myxomatous changes were successfully recapitulated in hypertensive mice, as determined by ECM remodeling, myofibroblast transformation, and serotonin signaling activation. These changes were at least partially reversed upon TE administration.ConclusionThis study provides the first evidence of TE as a potential therapeutic for myxomatous mitral disease, either used to prevent or reverse myxomatous degeneration.
Associations of body mass index with mortality in heart failure with preserved ejection fraction patients with ischemic versus non-ischemic etiology
Authors: Zeng Shan , Cai Xingming , Zheng Yuxiang , Liu Xiao , Ye Min 
Published: August 2022

BackgroundObesity could paradoxically improve prognosis in patients with heart failure (HF), termed the “obesity paradox.” Whether HF etiology could modify the “obesity paradox” is still controversial. In the present study, we aimed to assess the relationship between obesity and death in patients with heart failure with preserved ejection fraction (HFpEF) with non-ischemic versus ischemic etiologies.MethodsWe analyzed 3,360 HFpEF patients from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. Cox regression models were used to assess the association of obesity assessed by body mass index (BMI) with short-term and long-term death risk.ResultsOverweight and obesity were associated with a lower risk of long-term all-cause death in patients with non-ischemic HFpEF, even in those with class III obesity (adjusted HR: 0.61, 95% CI 0.38–0.97). However, in the ischemic subgroup, as obesity advanced, this paradoxical relationship was gradually attenuated and disappeared in class III obesity (adjusted HR: 0.93, 95% CI 0.56–1.57). Restricted cubic spline analyses confirmed the differential relationship of baseline BMI with risk of long-term death with a BMI higher than 30 kg/m2 in non-ischemic versus ischemic HFpEF. In the short-term follow-up, the beneficial effects of overweight and obesity on survival were consistently observed in all the BMI categories, with the nadirs of all-cause death risk at class III obesity category both in non-ischemic and ischemic subgroups.Conclusion“Obesity paradox” was evident both in non-ischemic and ischemic HFpEF during short-term follow-up, even in those with class III obesity. However, the beneficial effect of class III obesity disappeared during long-term follow-up in ischemic HFpEF.Clinical Trial Registration[https://clinicaltrials.gov], identifier [NCT00094302].
Case Report: Lack of Response to Givosiran in a Case of ALAD Porphyria
Authors: Graff Erica , Anderson Karl E. , Levy Cynthia 
Published: August 2022

Introduction: 5-Aminolevulinic acid dehydratase (ALAD) porphyria (ADP) is an autosomal recessive disease characterized by a profound deficiency in ALAD, the second enzyme in the heme biosynthetic pathway, and acute neurovisceral attacks with abdominal pain and peripheral neuropathy. Hemin infusions are often effective in treating and preventing such attacks. Givosiran was recently approved for prevention of attacks of acute hepatic porphyrias (AHPs), including ADP, but, to our knowledge, has not yet been applied in patients with this ultrarare disease.Case Description: We update the clinical course and report new treatment outcomes of a 32-year-old man with ADP managed for many years with weekly prophylactic hemin infusions. He has developed evidence of iron overload and was more recently found to have compensated cirrhosis. The patient was started on givosiran (Givlaari™, Alnylam), a small interfering RNA (siRNA) therapeutic that is effective in preventing frequently recurring attacks of acute intermittent porphyria (AIP), the most common type of AHP.Discussion: No adverse effects of givosiran on the liver were observed in this patient with cirrhosis during 6 months of treatment with givosiran. The patient has continued to have recurrent attacks, with transient decreases in ALA levels only as related to treatment of his attacks with hemin. Our experience limited to one patient with ADP suggests that givosiran may not be effective in this type of acute porphyria. Since ADP may have an erythropoietic component, treatment with hydroxyurea, which was beneficial in one previous case, is planned.
The commercialization of biospecimens from Indigenous Peoples: A scoping review of benefit-sharing
Authors: Tone-Pah-Hote Tarlynn , Redvers Nicole 
Published: August 2022

BackgroundThere is ongoing and increasing interest in the commercialization of biospecimen-derived products from Indigenous Peoples. Discourse on benefit-sharing specifically in the context of the commercialization of Indigenous Peoples biospecimens are currently lacking. A better understanding of the potential ethical imperatives is in need of exploration on this emerging topic. This review sought to elucidate through categorization the current discourse in the peer-reviewed literature on the commercialization of Indigenous Peoples' biospecimens from a benefit-sharing perspective.MethodsA scoping review methodology was utilized to perform a search of PubMed, CINAHL, Embase and Google Scholar. A two-stage screening process was used to assess the relevance of any included articles with subsequent manual open coding of articles. Content analysis was applied to identify the main categories and sub-categories within the article data.ResultsThirty-three articles met the inclusion criteria for analysis. Four overarching categories from the included articles were identified regarding the most common discourse on the commercialization of Indigenous Peoples' biospecimens from a benefit-sharing perspective, including: exploitation through biocolonialism, sovereignty and Indigenous rights, ethical considerations for benefit-sharing, and guidelines and standards concerns.ConclusionThis scoping review highlighted the crucial need to keep Indigenous communities at the center of research projects, ensuring any benefits, advancement, and potential commercial profits are returned to communities through clear and ethical agreements. We encourage all research institutions and institutional ethical review bodies to better clarify the collective needs and interests of Indigenous communities while centering their sovereignty and rights within the research process as it pertains to potential biospecimen product commercialization.
MicroRNA-451a and Th1/Th2 ratio inform inflammation, septic organ injury, and mortality risk in sepsis patients
Authors: Geng Feng , Liu Wei , Yu Li 
Published: August 2022

AimsMicroRNA-451a (miR-451a) regulates Th1/Th2 cell differentiation, inflammation, and septic organ injury in several experiments. Therefore, the present study aimed to explore the inter-correlation of miR-451a with the Th1/Th2 ratio, and their association with inflammation, septic organ injury, and mortality risk in patients with sepsis.MethodsConsecutively, 117 patients with sepsis and 50 healthy controls (HCs) were enrolled. Peripheral blood mononuclear cell samples were collected to detect miR-451a expression and the Th1/Th2 ratio in all subjects.ResultsMiR-451a (p &lt; 0.001), Th1 cells (p = 0.014), and the Th1/Th2 ratio (p &lt; 0.001) increased, while Th2 cells (p &lt; 0.001) declined in patients with sepsis compared with HCs. It was of note that miR-451a was positively correlated with Th1 cells (p = 0.002) and the Th1/Th2 ratio (p = 0.001), while it was negatively related to Th2 cells (p = 0.005) in patients with sepsis. Meanwhile, miR-451a and the Th1/Th2 ratio correlated with most of the following indexes: TNF-α, IL-1β, IL-6, C-reactive protein, sequential organ failure assessment (SOFA) score, or Acute Physiology and Chronic Health Evaluation II (APACHE II) score (most p &lt; 0.05). Moreover, miR-451a (p &lt; 0.001) and the Th1/Th2 ratio (p = 0.001) increased in deaths compared to survivors of sepsis; further ROC curve showed both miR-451a and the Th1/Th2 ratio possessed a certain value to predict mortality of patients with sepsis. Additionally, the Th1/Th2 ratio [odds ratio (OR): 2.052, p = 0.005] was independently related to 28-day mortality risk from multivariate logistic regression.ConclusionMiR-451a correlates with the Th1/Th2 ratio, and they both relate to inflammation, septic organ injury, and mortality risk in patients with sepsis.