bluuebunny/crossref_metadata_2025_split huggingface dataset:
A theory-informed, rapid cycle approach to identifying and adapting sustainability strategies: Optimizing depression treatment in primary care clinics seeking to sustain collaborative/integrated care (The Transform DepCare Study)”
Authors: Moise Nathalie , Paniagua-Avila Maria Alejandra , Barbecho Jennifer Mizhquiri , Blanco Luis , Dauber-Decker Katherine , Flores Samantha , McElhiney Martin , Serafini Maria , Straussman Darlene , Patel Sapana , Ye Siqin , Duran Andrea 
Published: May 2022

Abstract
Background: Few if any examples exist of how best to select and adapt sustainability strategies. We used a collaborative/integrated care use case to describe a novel, theory-informed, stakeholder engaged process for operationalizing sustainability strategies. Methods: Informed by the Behavior Change Wheel, we used mixed methods to identify key sustainability behaviors and determinants of sustainability before conducting a “sustainability mapping” phase to identify acceptable and equitable intervention functions and behavioral change techniques. Drawing on user centered design principles, we enlisted 22 national and local stakeholders to operationalize and adapt (e.g., content, functionality, workflow) a multi-level sustainability strategy to maximally target behavioral determinants of sustainability. Results: We identified ongoing provider treatment optimization and patient initiation as key sustainability behaviors in settings receiving external facilitation and fiscal implementation strategies. The most acceptable, equitable and feasible intervention functions included environmental restructuring, education, training, modeling, persuasion, and enablement. We determined that a waiting room delivered shared decision making and psychoeducation patient tool (DepCare) the results of which are delivered to providers as well as ongoing problem-solving/implementation team meetings with care managers would be the most acceptable and equitable multi-level strategy in diverse settings seeking to sustain CC programs. Key adaptations in response to contextual factors included expanding the DepCare tool to incorporate anxiety/suicide screening, triage support, multi-modal delivery, and patient activation (vs. shared decision making); pairing preference reports with decisional support as well as yearly onboarding/motivational provider and staff educational videos; shifting problem solving meetings from billing support to triage/reducing inappropriate referrals. Conclusion: We provide a roadmap for designing theory-informed, sustainability strategies and employing user centered design principles to adapt strategies to changing mental health landscapes.
FDI and Economic Growth in Indonesia: A Provincial and Sectoral Analysis
Authors: Fazaalloh Al Muizzuddin 
Published: May 2022

Abstract
Foreign direct investment (FDI) plays an essential role in growing the economy, where this role runs through two things, namely capital accumulation and technology transfer. However, in the literature, previous research findings are still inconclusive to show positive contributions of FDI on economic growth. Furthermore, while the impact of FDI on economic growth has been studied using sectoral data, there has been less research done using data at the provincial and sectoral levels. This study aims to analyze the impact of foreign direct investment (FDI) on economic growth employing sectoral data at the provincial level (33 provinces) in Indonesia over 2010-2019. Based on the fixed effects estimator (reghdfe), our estimation results prove that, in general, FDI significantly positively impacts economic growth in the Indonesian provinces. We also find that FDI in the mining, manufacturing, water, gas and electricity, hotels and restaurants, and real estate sectors has a significant positive effect on economic growth. Meanwhile, only FDI in the agricultural sector has a significant negative impact. Our estimation results confirm that FDI in the manufacturing sector contributes positively and has a considerable impact. The results are robust to the GMM System estimator, which considers the endogeneity problem.
Cost of Peer Mystery Shopping to Increase Cultural Competency in Community Clinics Offering HIV/STI Testing to Young Men Who Have Sex with Men: Results from the Get Connected trial
Authors: Phillips Victoria , Xue Zheng , Castillo Marne , Santiago Dalia , Wimbly Taylor , Hightow-Weidman Lisa , Stephenson Rob , Bauermeister Jose 
Published: May 2022

Abstract
Background: Cultural competency has been identified as a barrier to lesbian, gay, bisexual and transgender (LGBT) populations seeking care. Mystery shopping has been widely employed in the formal health care sector as a quality improvement (QI) tool to address specific client needs. The approach has had limited use in community-based organizations (CBO) due in part to lack of knowledge and resource requirement concerns. Several mystery shopping initiatives are now being implemented which focus on the LGBT population with the goal of reducing barriers to accessing care. One subset targets men who have sex with men (MSM) to increase uptake of HIV testing. No intervention investigates costs of these initiatives, a key aspect of sustainability. The Get Connected randomized control trial used peer-led, high intensity, mystery shopping to identify and help develop culturally competent HIV testing sites for young men who have sex with men (YMSM) in high incidence urban areas. Mystery shopping modelled use of centralized CBO, such as a public health department (PHD), to spearhead shopping in community clinics. Our objective was to determine the resource requirements and costs of using high-intensity, peer mystery initiated in the trial to inform sustainability. Methods: Through consultation with study staff, we identify a resource inventory for undertaking a mystery shopping program. We used activity-based costing to price each of the resource inputs. We classified costs as start-up and on-going implementation costs. We calculated costs for each category, total costs and cost per mystery shopper visit for the four-month trial and annually to reflect standard budgeting periods. Results: Recruitment and training of peer mystery shoppers were the most expensive tasks. Average start-up costs were $10,001 (SD $38,8). Four-month average implementation costs per visit were $228 (SD $1.97). Average annual implementation costs per visit were 33% lower at $151 (SD $5.60). Conclusions: Peer-led, mystery shopping of HIV-testing sites is feasible, and is likely affordable for medium to large public health departments.
Eoarchean/Hadean melts reveal arc-like trace element and isotopic chemistry
Authors: Chowdhury Wriju , Trail Dustin , Miller Martha , Savage Paul 
Published: May 2022

Abstract
Constraining the lithological diversity and geodynamic regime(s) of the earliest Earth is critical to understanding how our planet has evolved, and the discovery of Hadean- and Eoarchaean-age zircons has allowed us to directly analyse material from these eons. Here we use Jack Hills Zircon (JHZ) (3.3 - 4.2 Ga) analyses coupled with new experimental partitioning data to model the SiO2 wt.%, Si+O isotopic composition, and trace element (TE) contents of their parent melts; i.e., the composition of the Earth’s earliest crust. Comparing our derived JHZ parent melt Si+O isotopic compositions (-1.96≤ δ30SiNBS28 ≤0.39 ‰; 5.28 ≤δ18OVSMOW≤10.03 ‰) to younger continental crust lithologies, we conclude that the chemistry of the JHZ parent melts was influenced by the assimilation of serpentinites, cherts and silicified basalts, followed by igneous differentiation, leading to the formation of intermediate to felsic melts in the early Earth. Trace element measurements also show that the formational regime had an arc-like chemistry, consistent with the presence of mobile-lid tectonics in the Hadean. Moreover, based on the similarity of isotopic data derived for Eoarchaean and Hadean melts, we propose these continental-crust forming processes operated continuously, and uniformly, from the Hadean into the Archaean.
A prediction of the paths to equalization of basic public health services based on Gragh Neural Network(GNN)
Authors: Duan Min , Tan Tao , Zhang Binzhe , Zhou Xun 
Published: May 2022

Abstract
The contradiction between supply and demand of China's health resources has become increasingly prominent under the strategic requirement of “High-quality public health development”. Especially in the context of accelerated population aging and changes in the disease spectrum, chronic diseases and other health issues are increasingly concerned. The government, as the main supplier, have to solve the outstanding conflicts of imbalance in resource allocation in the region. Our study aims to analyze inequalities in the utilization behavior of basic public health services for chronic diseases, to explore the influence of both supply and demand elements, and to assess whether the balanced allocation of resources at different levels within a region can contribute to equalization of basic public health services. This study collected the health insurance swipe records of diabetic patients in S city, and visualizes the supply and demand of medical resources on a map. Secondly, we construct a heterogeneous graph neural network(GNN) of hospital-patient medical resource utilization to explore the combinatorial effects of unequal utilization. Finally, we predict the changes in patients' behavior after two supply optimization means of improving the service quality of primary care institutions and sinking of high-quality medical resources. The analysis shows that the utilization of regional healthcare resources is also influenced by the center-edge supply structure, and the concentration of high-quality resources in urban centers not only squeezes the utilization space of primary hospitals, but also causes difficulties in access to high-quality resources for patients in shortage areas, which results in an unreasonable trend of patient mobility. We predict that a balanced allocation of medical resources at all levels in the region will significantly reduce the need for chronic disease patients to seek high-quality medical resources over long distances, but the siphoning effect of regional medical centers still remains. The policy should further continue to increase the investment in primary health institutions while improving the radiation range of regional medical centers, and establish “close medical associations” to achieve equalization of basic public health services.
Development and validation of a surgical drill with a haptic interface in spine surgery
Authors: Yamanouchi Kento , Takano Shunya , Mima Yuichiro , Matsunaga Takuya , Ohnishi Kouhei , Matsumoto Morio , Nakamura Masaya , Shimono Tomoyuki , Yagi Mitsuru 
Published: May 2022

Abstract
Summary of Background Data.Real haptics is a technology that reproduces the sense of force and touch by transmitting contact information with real objects by converting human movements and the feel of objects into data. In recent years, real haptics technology could be installed in several surgical devices. Methods. A custom-made surgical drill was used to drill into the posterior lamina to verify the time required for penetration detection and the distance the drill advanced after penetration. The surgeon operated the drill, and the same aspects were measured and verified. All experiments were performed on female miniature pigs at 9 months of age with a mean body weight of 23.6 kg (range 9-10 months and 22.5-25.8 kg, n = 12) .Results.There were statistically significant differences in both the average reaction time and the distance travelled after penetration between a handheld drill and the drill with the penetration detection function (p<0.001, respectively). The reaction time to detect penetration and the distance after penetration were both significantly improved when compared with those of the handheld surgical drill without the penetration detection function, with mean differences of 0.049 ± 0.019 s [95% CI: 0.012, 0.086 s] and 2.511 ± 0.537 mm [95% CI: 1.505, 3.516 mm].Conclusions.In this study, we successfully conducted a performance evaluation test of a custom-made haptic interface surgical drill. A prototype high-speed drill with a haptic interface successfully detected the penetration of the porcine posterior lamina more accurately.
Dissecting the inheritance pattern of anemone type and the relevant floral traits of chrysanthemum in multiple segregating F1 populations
Authors: Yang Xiaodong , Su Jiangshuo , Qu Yixin , Jiang Jiafu , Guan Zhiyong , Fang Weimin , Chen Fadi , Zhang Fei 
Published: May 2022

Abstract
Anemone type, featuring prominent and colored in tubular florets, is an attractive flower shape in chrysanthemums and thus desired by breeders and consumers. Understanding the genetic basis of anemone-type flowers in chrysanthemum is crucial for breeding success. The current study conducted nine cross combinations from seven parents to investigate segregation patterns, parental effect, and the relationships between the heterosis of six tubular floral traits and parental genetic distance. The results showed significant (P < 0.05) differences between the parents and crosses in various tubular floral traits, and transgressive segregation was observed in both directions for most traits. The considerable variation was revealed for almost floral traits, thus indicating the substantial potential for selecting lines with the desirable traits. The segregation ratio of anemone to nonanemone followed 3:1 in anemone × anemone crosses and 1:3 in either nonanemone × anemone or anemone × nonanemone crosses, except for two reciprocal crosses derived from the parents ‘Nannong Xuefeng’ and ‘QX096’. The F1 hybrids’ performance was more inclined towards a vulnerable parent and involved less influence of maternal or paternal effects, displaying some extended declines and negative mid-parent heterosis (MPH). The phenotypic genetic distance was significantly negatively correlated with MPH for floral traits except for style length and disk flower diameter. In contrast, we observed no significant correlation between molecular marker-based genetic distance and MPH for all floral characteristics. The findings of the current work provide insights into the complex inheritance pattern of flower shapes and help achieve desirable improvement in anemone-type chrysanthemums.
Validation study of a nomogram for predicting probability of low risk of MammaPrint results in women with clinically high-risk breast cancer
Authors: Hwang Young Sol , Kim Hwa Jeong , Kim Jisun , Chung Il Yong , Ko Beom Seok , Kim Hee Jeong , Lee Jong Won , Son Byung Ho , Ahn Sei-Hyun , Lee Sae Byul 
Published: May 2022

Abstract
Purpose
MammaPrint (MMP) helps clinicians identify the ideal time for adjuvant treatment for patients with early HR+/HER2- breast cancer. We aimed to externally validate a nomogram designed to predict probability of low risk of MMP results and to evaluate the difference in survival outcome between two groups stratified by nomogram score.
Methods
In this retrospective cohort study, we evaluated 172 patients from Asan Medical Center, Seoul, Korea, who underwent breast cancer surgery and MMP during 2020–2021. We internally validated the nomogram by calculating the area under the curve (AUC) and using calibration. With the data of 1,835 T1-3N0-1M0 HR+/HER2- patients from Asan Medical Center during 2010–2013, we compared the disease-free survival (DFS), overall survival (OS), and breast cancer-specific survival (BCSS) rates by Kaplan-Meier analysis between the two groups divided by nomogram total point (TP) for externally validation.
Results
The AUC calculated by internal validation of 172 patients was 0.73 (95% confidence interval [CI], 0.77–0.87). The discrimination and calibration of the prediction model were satisfactory following external validation. The high-risk and low-risk groups had different 5-year OS (97.9% vs 98.1%, p = 0.056), DFS (98.6% vs 99.4%, p = 0.008), and BCSS rates (98.6% vs 99.4%, p = 0.002).
Conclusion
For treatment decision-making among clinically high-risk patients with HR+/HER2- and node-positive disease, the nomogram showed satisfactory performance in predicting patients with low genomic risk. Survival outcome significantly differed between two groups divided by nomogram TP. More studies are needed to validate this model in international cohorts and large prospective cohorts from other institutions.
Correlation of serum Nesfatin 1 level with metabolic and clinical parameters in Indian women with and without polycystic ovarian syndrome
Authors: Faeza Fatima , Pikee Saxena , Anju Jain 
Published: May 2022

Abstract
ObjectiveTo compare serum Nesfatin 1 levels in Indian women with and without PCOS and to evaluate the association of serum Nesfatin 1 with metabolic and clinical parameters.Methods and Material40 PCOS and 40 age and BMI matched non PCOS controls were enrolled. Comparison of hormonal (serum Nesfatin 1, AMH, FSH, LH, prolactin, testosterone, estadiol) metabolic (blood pressure, fasting and post prandial blood glucose and insulin, HOMA-IR ) and clinical (acne, acanthosis nigricans and hirsutism) parameters was done between two groups. Student’s t test, Mann Whitney test, Pearson’s correlation test were used. P value of < 0.05 was considered statistically significant.ResultsThere was a significant difference in levels of serum Nesfatin 1 in PCOS subjects and controls (8.6 ng/ml v.s 0.75 ng/ml, p < 0.01). Positive correlation was present between serum nesfatin 1 levels and post prandial plasma glucose (r = 0.009; p < 0.009). A positive correlation was also present between serum Nesfatin 1 levels and AMH (r = 0.512;p < 0.01). No correlation was found between serum Nesfatin 1 and other endocrine, cardiovascular and metabolic parameters. Serum LH levels, LH/FSH ratio, post prandial plasma glucose and post prandial insulin were significantly higher (P < 0.05). in PCOS subjects compared to controlsConclusionNesfatin1 levels were ten times higher in PCOS subjects compared to controls irrespective of age and BMI. A positive correlation was observed between serum Nesfatin 1 and post prandial plasma glucose levels which indicates Nesfatin 1 may be a reliable marker of PCOS suggesting energy homeostasis imbalance in these women.
Exploring the challenges faced by Kurdish migrant workers during the Covid-19 pandemic
Authors: khazaee-pool Maryam , Taymoori Parvaneh , Bahmani Afshin , ponnet koen , pashaei Tahereh 
Published: May 2022

Abstract
Background: With the outbreak of Covid-19, migrant workers have faced new and intensified problems. The present qualitative study aims to explore the challenges faced by Kurdish migrant workers during the Covid-19 pandemic.Methods: Applying a qualitative approach, we conducted 29 semi-structured in-depth qualitative interviews with Kurdish migrant workers who had temporarily migrated to Iraqi Kurdistan to find work. Inductive qualitative content analysis was employed to converge and compare themes in participant data.Results: The following five main themes emerged from the analysis: sociocultural challenges, economic challenges, psychological challenges, job challenges, and individual challenges. The findings revealed that the Covid-19 pandemic has had a negative effect on the physical, financial, psychological, and social well-being of migrant workers.Conclusions: This study emphasizes the importance of support measures for migrant workers during the Covid-19 pandemic, including insurance coverage and the provision of health services, such as access to vaccinations and border health screening, as well as the development of socio-economic support, the legislation of labor laws, and the obligation of employers to create a safe workplace during the Covid-19 pandemic.
The safety of time-lapse incubation system for embryo culture in assisted reproductive laboratory: A systematic review and meta-analysis
Authors: Liu Yongxiang , Shi Gaohui , Huang Guilan , Hou Wenhui , Cai Bing , Zhou Shaohu , Xu Yanwen 
Published: May 2022

Abstract
Background: To date, time-lapse incubation system (TLI) is widely used in assisted reproductive laboratory for continuously embryo observe and selection. But only few randomized controlled trials (RCT) have been published that evaluated the safety of TLI, especially the neonatal outcomes. We conducted a systematic review and meta-analyses to evaluate the neonatal outcomes between TLI and standard incubators (SI).Methods: A literature search up to October 2021 was carried out to search for clinical trials from electronic databases comparing TLI versus SI on neonatal outcomes. The summary measures were reported as odds ratio (OR) with 95% confidence-interval (CI). Results: A total of 5905 live-born infants were included from fresh embryos transfer cycles. Only singleton pregnancies were analyzed, no statistical differences were found with respect to gestational weeks at delivery (Mean difference=0.09; 95%CI, -0.18 to 0.35; I2=33%; P=0.52), preterm births (<37weeks) (OR=0.98; 95%CI 0.78 to 1.24; I2=0%; P=0.86), and early preterm birth (<32 weeks) (OR=0.41; 95%CI, 0.11 to 1.50; I2=50%; P=0.18). Besides, no statistical significances were also observed in TLI group on birth weight (Mean difference=71.61; 95%CI, -30.55 to 173.77; I2=62%; P=0.17), low birth weight rate (<2,500g) (OR=0.85; 95%CI, 0.64 to 1.13; I2=0%; P=0.26), very low birth weight rate (<1,500g) (OR=0.58; 95%CI, 0.17 to 1.96; I2=50%; P=0.38), and macrosomia rate (≥4,000g) (OR=1.11; 95%CI, 0.84 to 1.47; I2=0%; P=0.48). Moreover, incidences of malformations of babies delivered from TLI and SI groups were also similar (OR=1.19; 95%CI, 0.66 to 2.14; I2=0%; P=0.56). And finally, sex ratio analysis still showed no differences between the two groups (OR=2.16; 95%CI, 0.53 to 8.81; I2=96%; P=0.28). Conclusions: The strategy of culturing embryo in time-lapse incubation systems would not increase adverse risks of neonatal outcomes comparing to SI. Trial registration: PROSPERO (2018: CRD42020186807)
A missense variant in the nuclear localization signal of DKC1 causes Hoyeraal-Hreidarsson syndrome
Authors: TSENG Chi-Kang , Lee Ni-Chung , Chu Chia-Mei , Tsai Meng-Ju , Yu Hsin-Hui , Wu En-Ting , Yang Yun-Li , Lin Chin-Hsien , Lin Shin-Yu , Chien Yin-Hsiu , Hwu Wuh-Liang , Chen Wen-Pin 
Published: May 2022

Abstract
Hoyeraal-Hreidarsson syndrome (HHS) is the most severe form of dyskeratosis congenita (DC) and is caused by genes involved in telomere maintenance. Here, we identified male siblings from a family with HHS carrying a hemizygous mutation (c.1345C>G, p.R449G), located in the C-terminal nuclear localization signal (NLS) of the DKC1 gene. These patients exhibit progressive cerebellar hypoplasia, recurrent infections, pancytopenia due to bone marrow failure, and short leukocyte telomere lengths. Single-cell RNA sequencing analysis suggested defects in the NLRP3 inflammasome in monocytes and the activation and maturation of NK cells and B cells. In experiments using induced pluripotent stem cells (iPSCs) from patients, DKC1_R449G iPSCs had short telomere lengths due to reduced levels of human telomerase RNA (hTR) and increased cytosolic proportions of DKC1. Treatment with dihydroquinolizinone RG7834 and cordycepin rescued telomere length in patient-derived iPSCs. Together, our findings not only provide new insights into immunodeficiency in DC patients but also provide treatment options for telomerase insufficiency disorders.