bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanosilicate‐Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone
Authors: Sheng Renwang , Chen Jialin , Wang Hongmei , Luo Yifan , Liu Jia , Chen Zhixuan , Mo Qingyun , Chi Jiayu , Ling Chen , Tan Xin , Yao Qingqiang , Zhang Wei 
Published: June 2022

AbstractOsteochondral defects are characterized by injuries to both cartilage and subchondral bone, which is a result of trauma, inflammation, or inappropriate loading. Due to the unique biological properties of subchondral bone and cartilage, developing a tissue engineering scaffold that can promote dual‐lineage regeneration of cartilage and bone simultaneously remains a great challenge. In this study, a microporous nanosilicate‐reinforced enzymatically crosslinked silk fibroin (SF) hydrogel is fabricated by introducing montmorillonite (MMT) nanoparticles via intercalation chemistry. In vitro studies show that SF‐MMT nanocomposite hydrogel has improved mechanical properties and hydrophilicity, as well as the bioactivities to promote the osteogenic differentiation of bone marrow mesenchymal stem cells and maintain chondrocyte phenotype compared with SF hydrogel. Global proteomic analysis verifies the dual‐lineage bioactivities of SF‐MMT nanocomposite hydrogel, which are probably regulated by multiple signaling pathways. Furthermore, it is observed that the biophysical interaction of cells and SF‐MMT nanocomposite hydrogel is partially mediated by clathrin‐mediated endocytosis and its downstream processes. In vivo, the SF‐MMT nanocomposite hydrogel effectively promotes osteochondral regeneration as evidenced by macroscopic, micro‐CT, and histological evaluation. In conclusion, a functionalized SF‐MMT nanocomposite hydrogel is developed with dual‐lineage bioactivity for osteochondral regeneration, indicating its potential in osteochondral tissue engineering.
Turbostratic Boron–Carbon–Nitrogen and Boron Nitride by Flash Joule Heating
Authors: Chen Weiyin , Li John Tianci , Ge Chang , Yuan Zhe , Algozeeb Wala A. , Advincula Paul A. , Gao Guanhui , Chen Jinhang , Ling Kexin , Choi Chi Hun , McHugh Emily A. , Wyss Kevin M. , Luong Duy Xuan , Wang Zhe , Han Yimo , Tour James M. 
Published: June 2022

AbstractTurbostratic layers in 2D materials have an interlayer misalignment. The lack of alignment expands the intrinsic interlayer distances and weakens the optical and electronic interactions between adjacent layers. This introduces properties distinct from those structures with well‐aligned lattices and strong coupling interactions. However, direct and rapid synthesis of turbostratic materials remains a challenge owing to their thermodynamically metastable properties. Here, a flash Joule heating (FJH) method to achieve bulk synthesis of boron–carbon–nitrogen ternary compounds with turbostratic structures by a kinetically controlled ultrafast cooling process that takes place within milliseconds (103 to 104 K s−1) is reported. Theoretical calculations support the existence of turbostratic structures and provide estimates of the energy barriers with respect to conversion into the corresponding well‐aligned counterparts. When using non‐carbon conductive additives, a direct synthesis of boron nitride is possible. The turbostratic nature facilitates mechanical exfoliation and more stable dispersions. Accordingly, the addition of flash products to a poly(vinyl alcohol) nanocomposite film coating a copper surface greatly improves the copper's resistance to corrosion in 0.5 m sulfuric acid or 3.5 wt% saline solution. FJH allows the use of bulk materials as reactants and provides a rapid approach to large quantities of the hitherto hard‐to‐access turbostratic materials.
Formulating High‐Rate and Long‐Cycle Heterostructured Layered Oxide Cathodes by Local Chemistry and Orbital Hybridization Modulation for Sodium‐Ion Batteries
Authors: Xiao Yao , Wang Hong‐Rui , Hu Hai‐Yan , Zhu Yan‐Fang , Li Shi , Li Jia‐Yang , Wu Xiong‐Wei , Chou Shu‐Lei 
Published: June 2022

AbstractIt is still very urgent and challenging to simultaneously develop high‐rate and long‐cycle oxide cathodes for sodium‐ion batteries (SIBs) because of the sluggish kinetics and complex multiphase evolution during cycling. Here, the concept of accurately manipulating structural evolution and formulating high‐performance heterostructured biphasic layered oxide cathodes by local chemistry and orbital hybridization modulation is reported. The P2‐structure stoichiometric composition of the cathode material shows a layered P2‐ and O3‐type heterostructure that is explicitly evidenced by various macroscale and atomic‐scale techniques. Surprisingly, the heterostructured cathode displays excellent rate performance, remarkable cycling stability (capacity retention of 82.16% after 600 cycles at 2 C), and outstanding compatibility with hard carbon anode because of the integrated advantages of intergrowth structure and local environment regulation. Meanwhile, the formation process from precursors during calcination and the highly reversible dynamic structural evolution during the Na+ intercalation/deintercalation process are clearly articulated by a series of in situ characterization techniques. Also, the intrinsic structural properties and corresponding electrochemical behavior are further elucidated by the density of states and electron localization function of density functional theory calculations. Overall, this strategy, which finely tunes the local chemistry and orbitals hybridization for high‐performance SIBs, will open up a new field for other materials.
Blue LED‐Pumped Broadband Short‐Wave Infrared Emitter Based on LiMgPO4:Cr3+,Ni2+ Phosphor
Authors: Miao Shihai , Liang Yanjie , Zhang Yan , Chen Dongxun , Wang Xiao‐Jun 
Published: June 2022

AbstractBlue light‐emitting diode (LED) pumped short‐wave infrared (SWIR; 900–1700 nm) emitters are providing new solutions in the design of portable and cost‐effective infrared light sources for medical, surveillance, and spectroscopy applications by taking advantage of converter technology. However, desirable blue‐light‐excitable SWIR‐emitting phosphors with a peak wavelength longer than 1000 nm are lacking. Herein, a promising broadband SWIR phosphor is designed and developed by incorporating Cr3+‐Ni2+ ion pairs into LiMgPO4 host. Upon 450 nm blue light excitation, the as‐synthesized LiMgPO4:Cr3+,Ni2+ phosphor exhibits a broad and intense SWIR emission spanning from 1100–1600 nm with peak wavelength at 1380 nm and a full width at half maximum of 273 nm due to the efficient energy transfer from Cr3+ to Ni2+. Moreover, phosphor‐converted SWIR LED prototype device based on the combination of 450 nm blue LED chip and the optimized phosphor is fabricated as a new type of broadband illuminator covering the SWIR waveband, delivering a maximum radiant power of ≈2.7 mW at 120 mA driving current. Benefiting from the distinct spectral characteristics of SWIR light, the practical relevance of the fabricated SWIR illuminator is demonstrated in covert information identification and night vision lighting.
Discovery of a New Mcl‐1 Protein Inhibitor through the QSAR Approach and Molecular Docking Study
Authors: Byadi Said , Sadik Karima , Hachim Mouhi Eddine , Daoudi Mohamed , Podlipnik Črtomir , Aboulmouhajir Aziz 
Published: June 2022

AbstractIn this study, a quantitative structure‐activity relationship (QSAR) model of anticancer activity against myeloid cell leukemia 1 (Mcl‐1) for a series of 41 tricyclic indole diazepinone derivatives is established. Three different modeling methods, multiple linear regression (MLR), partial least square (PLS), and artificial neural network (ANN) are investigated to perform a QSAR model with significant predictiveness. A clustering method is also used for dividing all compounds into training and external test (ET) sets. Component principal analysis is used to eliminate the redundancy between descriptors. The accuracy and predictability of the proposed models are proven by comparing their key statistical terms. The good results obtained with the internal and external validations (EV) show that the proposed models can predict high‐performance activities and that the selected descriptors are pertinent. This model is also validated using internal validation (IV), mainly using cross‐validation (leave‐many‐out (LMOCV)). The applicability domain (AD) is identified. Based on the SAR map analysis, a novel Mcl‐1 inhibitor with a good predicted activity using the best model is proposed, the interaction of the designed compound with the binding site of Mcl‐1 protein is evaluated and its docking score is found high.
Selective Doping to Controllably Tailor Maximum Unit‐Cell‐Volume Change of Intercalating Li+‐Storage Materials: A Case Study of γ Phase Li3VO4
Authors: Deng Jianbin , Lv Changpeng , Jiang Tian , Ma Siyuan , Liu Xuehua , Lin Chunfu 
Published: June 2022

AbstractCapacity decay of an intercalating Li+‐storage material is mainly due to the its particle microcracks from stress‐causing volume change. To extend its cycle life, its unit‐cell‐volume change has to be minimized as much as possible. Here, based on a γ‐Li3VO4 model material, the authors explore selective doping as a general strategy to controllably tailor its maximum unit‐cell‐volume change, then clarify the relationship between its crystal‐structure openness and maximum unit‐cell‐volume change, and finally demonstrate the superiority of “zero‐strain” materials within 25–60 °C (especially at 60 °C). With increasing the large‐sized Ge4+ dopant, the unit‐cell volume of γ‐Li3+xGexV1−xO4 becomes larger and its crystal structure becomes looser, resulting in the decrease of its maximum unit‐cell‐volume change. In contrast, the doping with small‐sized Si4+ shows a reverse trend. The tailoring reveals that γ‐Li3.09Ge0.09V0.91O4 owns the smallest maximum unit‐cell‐volume change of 0.016% in the research field of intercalating Li+‐storage materials. Consequently, γ‐Li3.09Ge0.09V0.91O4 nanowires exhibit excellent cycling stability at 25/60 °C with 94.8%/111.5% capacity‐retention percentages after 1800/1500 cycles at 2 A g−1. This material further shows large reversible capacities, proper working potentials, and high rate capability at both temperatures, fully demonstrating its great application potential in long‐life lithium‐ion batteries.
Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection
Authors: Xu Shiqi , Yang Xi , Liu Wenhui , Jönsson Joakim , Qian Ruobing , Konda Pavan Chandra , Zhou Kevin C. , Kreiß Lucas , Wang Haoqian , Dai Qionghai , Berrocal Edouard , Horstmeyer Roarke 
Published: June 2022

AbstractNoninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well‐established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep‐tissue video reconstruction of decorrelation dynamics. In this work, a single‐photon avalanche diode array camera is utilized to simultaneously monitor the temporal dynamics of speckle fluctuations at the single‐photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. Then a deep neural network is applied to convert the acquired single‐photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. The ability to reconstruct images of transient (0.1–0.4 s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter‐scale resolution is demonstrated, and it is highlighted how the model can flexibly extend to monitor flow speed within buried phantom vessels.
Palladium‐Catalyzed Asymmetric Allylic Cycloaddition of Vinylethylene Carbonates with Nitroalkenes: A Route to Tetrahydrofurans bearing Vicinal Tetrasubstituted Stereocenters
Authors: Zhao Can , Khan Sardaraz , Khan Ijaz , Shah Babar Hussain , Zhang Yong Jian 
Published: June 2022

AbstractAn efficient method for the diastereo‐ and enantioselective construction of tetrahydrofurans bearing three continuous stereocenters including vicinal tetrasubstituted stereocenters via palladium‐catalyzed asymmetric allylic cycloaddition of vinylethylene carbonates with nitroalkenes was developed. By using a palladium complex generated in situ from [Pd2(dba)3] ⋅ CHCl3 and (R)‐BINAP ligand as a catalyst under mild reaction conditions, the process provides multi‐functionalized tetrahydrofurans in good yields with excellent stereoselectivities.
Well‐dispersed poly(ether‐ether‐ketone)/multi‐walled carbon nanotubes nanocomposite for harsh environment applications
Authors: Jiang Zhiyuan , Zhu Zewen , Zhao Mingzhen , Chen Hengxi , Sue Hung‐Jue 
Published: June 2022

AbstractReinforcing poly(ether‐ether‐ketone) (PEEK) with multi‐walled carbon nanotubes (MWCNT) is of great interest for harsh environment applications, such as seals for oil and gas recovery because of its expected superior thermal and mechanical properties and environmental stability. In this research, a PEEK nanocomposite containing 10 wt% of well‐dispersed MWCNT was successfully prepared using a solution mixing approach. Compared to a commercial PEEK/PBI (polybenzimidazole) blend benchmark, PEEK/MWCNT exhibits significantly increased Young's modulus, much lower water absorption, and better modulus retention under hot‐wet conditions. Based on a physics‐based Ngai's Coupling model and calculation of activation energy on stress relaxation, PEEK/MWCNT system shows stronger intermolecular interaction and higher energy barrier for chain mobility than PEEK/PBI system under hot‐wet environment. These enhanced properties of PEEK/MWCNT nanocomposite are suitable for many high performance, harsh environment applications.
Immunomodulatory effect of Linalool (Lin) against CCl4‐induced hepatotoxicity and oxidative damage in rats
Authors: Hsouna Anis Ben , Sadaka Carmen , Beyrouthy Marc El , Hfaiedh Mbarka , Dhifi Wissal , Brini Faical , Saad Rania Ben , Mnif Wissem 
Published: June 2022

AbstractThe current study explored the hepatoprotective and immunomodulatory effects of Linalool (Lin) against carbon tetrachloride (CCl4)‐induced toxicity in mice. Four study groups (n = 8 each) were used: (1) a negative control group and (2) a toxicity control group (single dose of CCl4 administered on day 14 as 1 mL/kg of CCL4 in 1% olive oil). Intraperitoneally (i.p.)), and two experimental groups where mice were treated with either (3) Lin (25 mg/kg b.w., orally, daily for 15 days) or (4) pretreated with Lin (25 mg/kg b.w., orally, daily for 14 days) and intoxicated with CCl4 (1 mL/kg of CCL4 in 1% olive oil. i.p.) on day 14. The levels of the anti‐inflammatory cytokine interleukin 10 (IL‐10), the proinflammatory cytokines TNF‐α, IL‐6, and TGF‐1β, and the histopathology of the liver were assessed. According to our findings, IL‐10 concentrations were significantly increased in Lin‐treated groups, while other cytokine levels were marked by a considerable decrease in the toxicity model group (CCl4‐treated group). Histopathological examinations of liver tissues showed that the Lin‐treated groups had an almost normal structure. The current findings showed that Lin could inhibit CCl4‐induced liver injury in mice, which warrants further investigation of Lin as a potential protective and therapeutic agent against hepatotoxicity.
Paradox lost: Concerted evolution and centromeric instability
Authors: Haig David 
Published: June 2022

AbstractHomologous centromeres compete for segregation to the secondary oocyte nucleus at female meiosis I. Centromeric repeats also compete with each other to populate centromeres in mitotic cells of the germline and have become adapted to use the recombinational machinery present at centromeres to promote their own propagation. Repeats are not needed at centromeres, rather centromeres appear to be hospitable habitats for the colonization and proliferation of repeats. This is probably an indirect consequence of two distinctive features of centromeric DNA. Centromeres are subject to breakage by the mechanical forces exerted by microtubules and meiotic crossing‐over is suppressed. Centromeric proteins acting in trans are under selection to mitigate the costs of centromeric repeats acting in cis. Collateral costs of mitotic competition at centromeres may help to explain the high rates of aneuploidy observed in early human embryos.
Benchmarking sustainable E‐commerce enterprises based on evolving customer expectations amidst COVID‐19 pandemic
Authors: Pratap Saurabh , Jauhar Sunil Kumar , Daultani Yash , Paul Sanjoy Kumar 
Published: June 2022

AbstractThe 2019 coronavirus disease (COVID‐19) pandemic has seriously impacted the performance of all types of businesses. It has given a tremendous structural boost to e‐commerce enterprises by forcing customers to online shopping over visiting physical stores. Moreover, customer expectations of the digital and operational capabilities of e‐commerce firms are also increasing globally. Thus, it has become crucial for an e‐commerce enterprise to reassess and realign its business practices to meet evolving customer needs and remain sustainable. This paper presents a comprehensive performance evaluation framework for e‐commerce enterprises based on evolving customer expectations due to the COVID‐19 pandemic. The framework comprises seven primary criteria, which are further divided into 25 sub‐criteria, including two sustainability factors, namely, environmental sustainability and carbon emissions. The evaluation approach is then practically demonstrated by analyzing the case of three Indian e‐commerce firms. The results are obtained using a multi‐criteria decision‐making (MCDM) method, namely, Fuzzy VIKOR, to capture the fuzziness of the inherent decision‐making problem. Further, numerical analysis is conducted to evaluate and rank various e‐commerce enterprises based on customer expectations and satisfaction benchmarks. The findings explain the most important criteria and sub‐criteria for e‐commerce businesses to ensure customer expectations along with their economic and environmental sustainability.
Nitrogen rate and cultivar effects on zoysiagrass putting greens in the transition zone
Authors: Carr Tyler Q. , Sorochan John C. , Dickson Kyley H. 
Published: June 2022

AbstractZoysiagrasses (Zoysiaspp. Willd.) have been predominately used as turfgrass for residential and commercial lawns in addition to golf course fairways and tees due to reduced input requirements compared with bermudagrass (Cynodonspp.). The recent development of fine‐textured zoysiagrass cultivars has sparked interest in using zoysiagrass on putting greens. A complete‐factorial field experiment was conducted over replicate trials in Knoxville, TN to evaluate the putting green performance and quality of four zoysiagrass cultivars under two nitrogen (N) rates in the transition zone. Four zoysiagrass cultivars (Lazer, M85, Prizm, and Trinity) were treated with either 0.93 or 1.9 g N m−2every 2 wk over a 16‐wk period from June to September in 2020 and 2021. Ball roll distance, surface firmness, and turfgrass color were evaluated weekly. Lazer and M85 consistently provided the greatest ball roll distance and turfgrass color over both seasons, whereas Prizm occasionally exhibited similar performance and color. Lazer produced the firmest greens, whereas Prizm exhibited the softest surface. Trinity had reduced turfgrass color over both years, implying that it should not be used on putting surfaces. The 1.9 g N m−2rate reduced ball roll distance and increased turfgrass color but had limited effect on surface firmness. Applying 0.93 g N m−2increased ball roll distance, reduced turfgrass color, and maintained surface firmness similar to 1.9 g N m−2. Additionally, cultivar selection will likely affect putting green performance, playability, and quality.
Evaluation of longitudinal 13C isotope ratio mass spectrometric data in antidoping analysis
Authors: de la Torre Xavier , Jardines Daniel , Botrè Francesco 
Published: June 2022

AbstractThe detection of testosterone and its precursors' abuse in antidoping sports analysis is based on the longitudinal evaluation of markers of the urinary endogenous steroid profile. A Bayesian statistical approach is applied, allowing the establishment of credible intervals of the selected parameters for every athlete. Samples showing values outside the acceptable boundaries are selected for additional confirmation by isotope ratio mass spectrometric (IRMS) analysis. The alterations of the IRMS values last longer than the alterations of the steroid profile. Then the application of IRMS to a larger number of samples, at a screening level, would presumably allow detection of additional positive cases. The steroid profile and IRMS data can be treated using the same Bayesian inference procedure. In nonsports population, we have demonstrated the stability of IRMS data. In this work, we studied the variability of these data in real conditions, in samples collected on athletes subjected to antidoping analyses over the years. The data obtained confirmed previous observations and the applicability of the proposed approach. The results of cases where confounding factors of the steroid profile were reported are discussed, showing that in most of the cases no significant changes are observed over the absolute delta values. Changes in diet may significantly change the absolute delta values but not the ones relative to endogenous reference compounds. Finally, a case that could have been evaluated as normal with the current approach without a thorough review of the data was detected as positive by the proposed approach, demonstrating the benefit of its application.
C‐reactive protein “at first sight”: Standard postoperative trend in gynecological surgery and a comparative analysis with white blood cell levels
Authors: De Cicco Nardone Carlo , De Luca Cristiana , Plotti Francesco , Fabris Silvia , Rossini Gianmarco , Montera Roberto , Luvero Daniela , Angioli Roberto , Terranova Corrado 
Published: June 2022

AbstractObjectiveThere is a lack of information about the normal trend of C‐reactive protein (CRP) blood levels in the postoperative days after gynecological benign surgery. We investigated the impact of different surgical techniques on CRP trend. We performed a comparative analysis between a CRP and white blood cell (WBC) trend in postoperative monitoring.MethodsWe studied 207 surgical patients for benign gynecological pathology. We analyzed CRP and WBC levels after surgery in the total number of women and separately by approaches.ResultsCRP mean log scores showed a typical behavior. Moreover, results from chi‐square test underline that the proportion of women with this result is independent from the type of surgery they underwent. Log score mean values of CPR differed between all groups and between times. No difference in the mean number of white cells between the second and the third day was found, as observed for CRP.ConclusionsOur study shows a trend reference model in postoperative monitoring of patients with benign gynecological surgery. The comparative analysis between the CRP and WBC trend in the postoperative days provided us data demonstrating the superiority of CRP in postsurgical patient outcomes monitoring.