bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and correlates of alcohol use and alcohol use disorder among undergraduate students in Johannesburg, South Africa: a cross-sectional study
Authors: Chen Cassandra , Mpinganjira Mafuno G , Motilal Asha , Matukane Sandile , Letsoalo Relebohile , McKee Tyler , Ntombela Zakithi , Mbulaheni Limuwani , Hargovan Taveer , Francis Joel M 
Published: November 2022

Abstract
Background: Alcohol use and alcohol use disorder (AUD) are a significant public health problem globally. Young people, including university students, are among the most affected populations. We conducted the study to determine the prevalence and correlates of alcohol use and AUD among undergraduate students in the Faculty of Health Sciences at the University of the Witwatersrand, South Africa.
Methods: We conducted a cross-sectional study using an anonymous, self-administered online survey in REDCap. The survey questionnaire consisted of socio demographic, and alcohol use questions using the AUD identification screening tool (AUDIT-C). We performed descriptive statistics, bivariate and multivariable logistic regression to determine factors associated with alcohol use and AUD. The p-value of <0.05 was considered statistically significant.
Results: The response rate was 15.7%, most participants were female (69.6%), in their 3rd and 4th year of study; and the largest racial representation was from those identifying as White (38.1%). The prevalence of reported ever use of alcohol was 79.1%, and among the ever users; 70.2% reported alcohol use in the last 12-months, 37.1% reported alcohol use in the last 30 days. The prevalence of AUD was 54.8% among ever drinkers. Factors significantly associated with reported current alcohol use were family members alcohol use as follows: siblings (aOR = 1.79, 95% CI: 1.02-3.15) and parents (aOR = 2.58, 95% CI: 1.39–4.80), white race (aOR = 5.70, 95% CI: 3.12–10.41), and high exposure to alcohol in the media (aOR = 3.31, 95% CI: 1.07–10.24). Whereas those associated with AUD were: Indian/Asian race (aOR = 2.82, 95% CI: 1.09-7.31), White race (aOR = 2.15, 95% CI: 1.14-4.04), and most of the time (aOR = 3.42, 95% CI: 1.29-9.04) and high (aOR = 3.31, 95% CI: 1.07-10.24) exposure to alcohol through media.
Conclusion: The reported alcohol use and AUD were common amongst undergraduate students at Wits university. There is an urgent need to design, pilot and adapt targeted interventions for this population group.
Antileukotriene drugs as a tool for improving the quality of life in patients with allergic rhinitis
Authors: Simsova V. A. , Ovchinnikov A. Yu. , Miroshnichenko N. A. , Ryabinin V. A. 
Published: November 2022

Introduction. Allergic rhinitis (AR) is immunoglobulin E (IgE) mediated disease. Which, after exposure to allergens, manifests itself with various symptoms such as sneezing, runny nose, nasal itching, and nasal congestion, which seriously affects the quality of life of patients. In some patients, AR poses a risk of developing serious mental disorders. Currently, various medicines are used for treatment. Objective. Consideration of the effectiveness of AR therapy with antileukotriene drugs, depending on the mental state of the patient. Materials and methods. The study involved 200 people diagnosed with AR. The patients were divided into 2 groups: group 1 (100 people) with basic therapy with intranasal glucocorticosteroids (inGCS – mometasone furoate) and group 2 (100 people) – inhalers in combination with an antileukotriene drug (montelukast). All were screened for the presence of a depressive disorder. The tactics of case management and prescription of drugs were defined by the level of depression. Patients with AR have mental health problems that correlate with AR symptoms. Results. Patients of the 1st group, who did not achieve complete relief of AR symptoms, when assessing their mental state using the PHQ-2 and PHQ-9 questionnaires, showed a mild depression (23 people). The symptoms of AR were stopped, when an anti-leukotriene drug was added to the therapy. Conclusions. With the ineffectiveness of the basic therapy of inGCS and a negative assessment of the patient’s mental state, the use of an antileukotriene drug is justified to improve the level of depressive mood and complete relief of symptoms of AR.
Therapeutic and diagnostic approaches in the treatment of chronic tonsillitis
Authors: Korkmazov M. Yu. , Yastremsky A. P. , Kornova N. V. , Lengina M. A. , Korkmazov A. M. 
Published: November 2022

Introduction. The relevance of the treatment of chronic tonsillitis is due to both the high prevalence and severity of the course of the disease with the variable development of tonsillogenic complications, both local and general. Important aspects are not always effective results of conservative methods of treatment, including the use of antibacterial drugs and, as a result, a decrease in the quality of life of patients. Objective. Based on the dynamics of blood leukocyte indices and local signs of chronic tonsillitis, to determine the effectiveness of a course of treatment using an effective antimicrobial agent of plant origin in patients of various age groups. Materials and methods. A prospective study was conducted in 494 patients aged 8 to 58 years who were treated on an outpatient basis for more than two years. Depending on the form of the disease and ongoing therapy, patients were randomly divided into 4 subgroups. Results and discussion. Evaluation of the effectiveness of treatment in groups of patients was carried out according to the indices in the leukocyte formula. A decrease in the average values of the indices was verified in most patients, which manifested itself in the activation of the phagocytic process with an antimicrobial herbal preparation and made it possible to reduce the manifestations of local and systemic clinical symptoms of chronic tonsillitis. Conclusion. Based on an objective assessment of the manifestations of local symptoms of chronic tonsillitis and an analysis of the dynamics of leukocyte blood indices, the effectiveness of a course of treatment with the inclusion of an antimicrobial agent of plant origin in patients of various age groups was shown.
The forgotten threat of cholera in Syria
Authors: Al-Abdulla Orwa , Alaref Maher 
Published: November 2022

Abstract
Cholera is an ancient disease that persists as an issue of public health in many conflict-affected countries worldwide. Cholera is a diarrheal infection caused by ingested water or food contaminated with the bacterium Vibrio cholerae. On 10 September 2022, the Ministry of Health in Syria declared a cholera outbreak. Poor water and sanitation systems, disease surveillance breakdown, the collapse of the health system, and deteriorated socioeconomic conditions are potential risk factors for the outbreak's spread. Identifying the context-related factors associated with the spread of disease is a core to developing practical response mechanisms. In this study, we suggested a multisectoral approach that addresses context-specific elements contributing to the cholera outbreak spread in Syria; public health determinants, geopolitics, risk factors, and pandemic fatigue.
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae
Semen with Hepatoprotective Effects
Authors: Zhang Ying , Xu Shuya , Liu Mengnan , Xu Xinfang , Han Ting , Jia Zhe , Li Xiangri , Lin Ruichao 
Published: November 2022

Background:
Salt-processed product of cuscutae semen (SCS), which is documented in Chinese pharmacopoeia
(2020 edition), is one of the processed products of cuscustae semen. SCS possesses hepatoprotective effects.
However, Pharmacokinetic/Pharmacodynamic (PK-PD) study of SCS with intervening acute liver injury (ALI) has
not been reported yet. Effective constituents are still not well addressed.

Objective:
This study was performed to study PK-PD properties with the purpose of linking SCS hepatoprotective
effects to key therapeutic outlines to guide therapeutic use in clinical settings.

Methods:
Rats were orally administered SCS after the acute liver injury model was established. Plasma biochemical
analysis, antioxidative analysis, and liver histopathology were measured to evaluate the hepatoprotective effects of
SCS. Blood samples were collected at different time points (0 h, 0.083 h, 0.25 h, 0.5 h, 1 h, 1.5 h, 2 h, 3 h, 4 h, 8 h,
12 h, 24 h) for PK/PD study after SCS administration. Contents of chlorogenic acid, hyperoside and astragalin were
estimated by UHPLC-ESI-MS. The relationship between concentrations of chlorogenic acid, hyperoside, and
astragalin and hepatoprotective effects was assessed by PK-PD modeling.

Results:
The results showed that SCS ameliorated liver repair and decreased the serum levels of alanine aminotransferase
(ALT), aspartate transaminase (AST) markedly. Hepatic oxidative stress was inhibited by SCS, as evidenced
by a decrease in malondialdehyde (MDA) and an increase in glutathione (GSH) and superoxide dismutase (SOD) in
the liver. PK-PD correlation analysis indicated that concentrations of chlorogenic acid, hyperoside, and astragalin
were negatively correlated with level of AST and ALT.

Conclusion:
The encouraging finding indicates that SCS has beneficial effects on CCl4-induced liver damage. Chlorogenic
acid, hyperoside, and astragalin are three effective constituents to exert hepatoprotective effects while astragalin
may have maximum pharmacological activity. PK-PD study reveals the positive relationship between drug concentration
and action intensity of SCS against liver injury. This research provides a robust foundation for future studies.
Antidepressant-like Properties of Melatonin and Atorvastatin Combination
following the Restraint Stress in Mice: A Study of Oxidative Stress
Factors
Authors: Nikoui Vahid , Hosseinzadeh Azam , Khotab Solmaz Javadi , Mousavi Seyyedeh Zahra , Abolmaali Meysam , Mehrzadi Saeed 
Published: November 2022

Background:
Antidepressant properties of melatonin and atorvastatin have been reported
by clinical and experimental studies. Since both melatonin and atorvastatin possess antioxidant
properties and considering the involvement of oxidative stress factors in depression, the aim of the
present investigation was to study the possible role of oxidative stress factors in the antidepressant-
like effect of melatonin and atorvastatin combination in mice forced swimming test.

Methods:
Following the induction of restraint stress, mice were randomly divided into eight
groups including the non-stressed and stressed vehicle-treated groups, melatonin- and atorvastatintreated
groups, a combination of melatonin and atorvastatin-treated group, and fluoxetineadministrated
group. The open field test (OFT) and forced swimming test (FST) were carried out,
and the hippocampus and prefrontal cortex were removed for the measurement of oxidative stress
factors.

Results:
Induction of restraint stress increased the immobility time in FST, and melatonin (10
mg/kg) significantly reduced it. Atorvastatin at both doses of 1 and 10 mg/kg could not alter the
immobility time, significantly. Co-administration of melatonin and atorvastatin (10 mg/kg) exerted
a significant antidepressant-like response and decreased the immobility time compared with melatonin
or atorvastatin (10 mg/kg), alone. Induction of restraint stress elevated the malondialdehyde
(MDA) levels in mice's hippocampus, while pretreatment of animals with atorvastatin (10 mg/kg)
could reverse it. The co-administration of melatonin and atorvastatin (10 mg/kg) increased the cortical
superoxide dismutase (SOD) activity compared with atorvastatin alone, but could not alter the
catalase (CAT) activity.

Conclusion:
It is concluded that atorvastatin might augment the antidepressant-like properties of
melatonin in FST.
Investigation of the Impact of Tropical Red Clay Soils' Mineralogical Composition on their Physical and Mechanical Properties– a Case Study Ruaka – Kenya
Authors: Hassan Samar Ali , Shitote Stanley Muse , Thuo Joseph Ng'ang'a 
Published: November 2022

Introduction:
Residual soils covering large areas of the earth have been chiefly discovered in the last 30 years in most volcanic tropical and subtropical countries. Understanding their behaviour is essential for various infrastructure developments.

Methods:
The physical and mechanical properties of the soils are affected by their mineralogical composition. There is a need to determine the mineralogical composition of the soils and investigate the impact on properties. This paper presents the results of a laboratory study conducted on red clay soil from Ruaka, a suburb in Kenya, to investigate the effect of mineral and chemical composition on the soil’s physical and mechanical properties. Disturbed and undisturbed samples were subjected to different tests such as Atterberg limits, soil classification, consolidation test, X-ray fluorescence, X-ray diffraction and petrology test based on the British Standard soil classification system (1377-1994). The soils were classified as clay with high plasticity, and high clay content varied between 59-79% resulting in mechanical instability of the soil in this site.

Results:
The mineral and chemical analysis indicated the formation of unique minerals like Halloysite, Quartz, Kaolinite, and Mica, which influenced the geotechnical properties of clay. The index properties of clay recorded high values; the moisture content and plastic limit varied between 37- 46% with a slight increase as depth increased; the liquid limit varied between 63-68% with increased depth.

Conclusion:
The average value of maximum dry density was reported as around 1247 kg/m3 with high optimum moisture content, reaching 35.5%. Besides that, the soil had a high void ratio of 1.145 to 1.63, which increased the permeability of the clay to 1.223E-5 cm/s. The properties of red clay soils in more than ten tropical regions in Kenya compared with the soil under study are also presented in this paper.
Auditor Style and Common Disclosure Issues: Evidence from SEC Comment Letters
Authors: Baugh Matthew D. , Schmardebeck Roy 
Published: November 2022

ABSTRACT
Policies and procedures that centralize decision making within an audit firm create auditor style effects. Prior research suggests this style increases financial-statement comparability, implicitly making financial statements more useful. However, a potential hazard of auditor style is the propagation of decision errors. We examine the association between auditor style and common disclosure issues among audit clients. We measure auditor style as the presence of a common auditor and use comments given in the Securities and Exchange Commission’s (SEC’s) filing-review process to measure the occurrence of common disclosure issues. We find that auditor style is associated with common disclosure issues among Big 4 clientele. We also find that clients with the same auditor converge in issues as tenure increases and some evidence that clients assume the issues of a subsequent auditor. These results provide the first evidence that auditor style has potential costs in the form of common disclosure issues.
Data Availability: All data are publicly available.
JEL Classifications: M41; M42.
Prediksi Financial Distress Sebelum dan Selama Masa Pandemi Covid-19
Authors: Kassidy Carissa Lorenza , Handoko Jesica 
Published: November 2022

This study aims to determine the differences in the predictions of financial distress before and during the pandemic. A single variable is used in the study from the calculation of the financial distress prediction model. The prediction model used in this study is the prediction model of Grover, Springate, Taffler and Zmijewski. The object of research is a manufacturing company listed on the Indonesia Stock Exchange in the 2018-2020 period. Hypothesis testing using Paired Sample T-Test. The results showed differences in the predictions of financial distress using the Springate and Taffler prediction models before and during the COVID-19 pandemic. Meanwhile, the results of predictions of financial distress with the prediction model of Grover and Zmijewski tend not to show any difference. This finding implies that the use of earnings before interest and tax ratios in the Springate model and the Taffler model is better able to predict financial distress before and during the pandemic than other models that use profit after tax indicators.
Keywords: Financial Distress; Grover; Springate; Taffler; Zmijewski
Manajemen Barang Milik daerah dan Optimalisasi Pengelolaan Aset Provinsi X
Authors: Periansya Periansya , Sari Yuliana , Azmi Farah 
Published: November 2022

This study aims to determine the relationship between regional property management to the optimization of asset management as well as planning, identification of BMD, BMD inventory and supervision and control as a variable. Data were collected from employees of the regional financial and asset management agency of South Sumatra Province through a structured questionnaire. The sample used was 56 employees at the Regional Financial and Asset Management Agency of South Sumatra Province and analyzed using SPSS version 25. The results showed that the Planning and Supervision and Control variables had a significant positive effect on the optimization of asset management, while the BMD Identification variable had a negative effect. Inventory BMD does not affect the optimization of asset management.
Keywords: Planning; Identification; Inventory; Supervision and Control; Optimization of Asset Management
Determinan Tax Compliance dengan Moral Wajib Pajak UMKM sebagai Variabel Moderasi
Authors: Susanto Freddy , Pituringsih Endar , Sakti Dwi Putra Buana 
Published: November 2022

The purpose of this study is to analyze the effect of tax incentives, tax sanctions on tax compliance where tax morale acts as a moderating variable during the pandemic on MSME taxpayers. The research was conducted in the city of Mataram, West Nusa Tenggara Province. The sampling technique used purposive sampling method with a sample of 100 respondents. Respondents consist of MSME taxpayers or have a turnover of less than 4.8 billion rupiah, be it a business entity or an individual entrepreneur, and take advantage of tax incentives during the pandemic. The data collected is processed using smartPLS 3. The test results found that tax incentives and tax sanctions have an effect on tax compliance. The results of this test are in accordance with attribution theory and justice theory. Where the influence of individual behavior is driven from internal and external where one of them is tax incentives and tax sanctions. However, the study did not find the effect of tax incentives and tax sanctions when moderated by tax morale on tax compliance.
Keywords: Tax Incentives; Tax Sanctions; Tax Morals; Tax Compliance
Peran Good Corporate Governance dalam Memoderasi Pengaruh Penghindaran Pajak dan Profitabilitas Pada Nilai Perusahaan
Authors: Putu Sisilia Dewi , Hasibuan Henny Triyana 
Published: November 2022

The purpose of this study was to determine the effect of tax avoidance and profitability on firm value with good corporate governance (GCG) as a moderating variable. The observed companies are manufacturing companies listed on the Indonesia Stock Exchange in 2018-2020. The number of samples used in the study were 77 companies with purposive sampling technique. The data analysis technique used is moderated regression analysis (MRA). The results showed that tax avoidance had no effect on firm value and good corporate governance (GCG) was unable to moderate the effect of tax avoidance on firm value. The study also found that profitability had a positive effect on firm value and good corporate governance (GCG) was able to strengthen the influence of profitability on firm value.
Keywords: Firm Value; Good Corporate Governance; Profitability, Tax Avoidance.
Penerapan Sistem E-Faktur dan Kepatuhan Pengusaha Kena Pajak dengan Pemahaman Internet Sebagai Variabel Moderasi
Authors: Kusumawati I Gusti Ayu Putu , Jati I Ketut 
Published: November 2022

The e-invoice system is an electronic tax invoice application provided by the Directorate General of Taxes that can be accessed via the internet to facilitate taxable entrepreneurs in carrying out their tax obligations. This study aims to determine the effect of the e-invoicing system on the compliance of taxable entrepreneurs with the understanding of the internet as a moderating variable. The research was conducted on taxable entrepreneurs registered at the South Badung Pratama Tax Service Office. The research sample amounted to 60 using the convenience sampling method. The data analysis technique used is Simple Linear Regression Analysis and Moderated Regression Analysis (MRA) Method. The results showed that the e-invoicing system variable had a positive and significant effect on the Compliance of Taxable Entrepreneurs, while the understanding of the internet did not moderate the effect of the Implementation of the E-Invoicing System on the Compliance of Taxable Entrepreneurs.
Keywords E-Invoices; Taxable Entrepreneur Compliance; Internet Understanding.
Kepemilikan Institusional, Likuiditas, Capital Expenditure, Profitabilitas dan Corporate Cash Holding di Masa Pandemi Covid-19
Authors: Ikhsani Misyka Qalbiya Nugrha , Gurendrawati Etty , Nasution Hafifah 
Published: November 2022

This study aims to determine how the influence of institutional ownership, liquidity, Capital Expenditure, and profitability on corporate cash holding (CCH) during the Covid-19 Pandemic. The research population is trading, service and investment sector companies listed on the Indonesia Stock Exchange (IDX) in 2020. The sample is 115 using purposive sampling technique. This study uses multiple linear regression analysis, with the type of secondary data processed through the IBM SPSS version 25 application. The results showed that institutional ownership and Capital Expenditure had no effect on CCH. Meanwhile, liquidity and profitability have a positive effect on CCH.
Keywords: Corporate Cash Holding; Institutional Ownership; Liquidity; Capital Expenditure; Profitability
Challenges and Strategies using Application in Online Teaching during Pandemic
Authors: Tukan Fransiska M. Ena 
Published: November 2022

This study aims to explain (1) the teacher’s challenges using the application in online teaching classroom during the COVID-19 pandemic, and (2) the strategies used by teachers in teaching using the application. The participants of the research were the English teachers at SMA/SMK/MA in Yogyakarta, Gunungkidul, Magelang, and Kebumen. A qualitative method was employed in this research and using interviews via WhatsApp as a data collection technique. The findings showed that teachers had the challenges such as (1) operating the application during online learning, (2) developing the material, assessment, and evaluation in teaching, (3) developing the teaching method, (4) combining the material and application, and (5) motivating the students and parents. The strategies used by the teacher when using the application in teaching such as (1) watching the video tutorial, (2) choosing a suitable application for teaching, (3) arranging the new learning schedule, (4) developing the creativity in designing the material, and (5) giving the simple material and task for the students.