bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of circadian rhythm and prognostic variability pre-and post-CEA or CAS treatment in patients with carotid artery stenosis
Authors: Quan Yi , Wang Zhongzhu , Zhang Tao , Sui Yanyong , Zhang Xin , Ji Xueliang , Liu Ao-fei , Jiang Weijian 
Published: January 2025

ObjectiveCarotid artery stenosis, primarily caused by atherosclerosis, is a major risk factor for ischemic stroke. Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are established interventions to reduce stroke risk and restore cerebral blood flow. However, the effect of these treatments on circadian rhythms, and their influence on stroke recovery, remains underexplored. This study aims to assess how disruptions in circadian rhythms—specifically sleep quality and blood pressure variability—impact recovery in patients undergoing CEA or CAS.MethodsWe conducted a prospective study involving 177 patients with carotid artery stenosis, all treated with either CEA or CAS. Patients were followed for 90 days post-treatment, with neurological outcomes evaluated using the NIHSS Stroke Scale (NIHSS). Circadian rhythm-related factors, including sleep quality (Pittsburgh Sleep Quality Index [PSQI]) and blood pressure variability (daytime systolic and nighttime diastolic BP), were assessed pre-and post-treatment. Stepwise regression was used to identify predictors of stroke recovery.ResultsIn a cohort of 177 patients with symptomatic carotid atherosclerotic stenosis, stepwise regression identified post-treatment changes in PSQI, nighttime diastolic blood pressure, and the presence of coronary heart disease as significant independent predictors of poor neurological outcomes (p &lt; 0.001). Both CEA and CAS significantly improved daytime systolic (p &lt; 0.01) and nighttime diastolic blood pressure (p &lt; 0.01). Patients with poorer prognosis had higher post-treatment PSQI scores (p &lt; 0.001). Additionally, increased physical activity after treatment was linked to improved neurological recovery.ConclusionThis study highlights the critical role of circadian rhythm regulation and cardiovascular health in stroke recovery following CEA or CAS. Stepwise regression analysis revealed that sleep quality, blood pressure stability, and coronary heart disease were key predictors of neurological outcomes, underscoring the importance of integrating circadian rhythm management into rehabilitation strategies. These results provide a robust scientific foundation for further investigation into the role of circadian rhythms in clinical practice.
Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series
Authors: Wagemann Olivia , Brendel Matthias , Franzmeier Nicolai , Nübling Georg , Gnörich Johannes , Zaganjori Mirlind , Prix Catharina , Stockbauer Anna , Wlasich Elisabeth , Loosli Sandra V. , Sandkühler Katja , Frontzkowski Lukas , Höglinger Günter , Levin Johannes 
Published: January 2025

Purpose of the reportAdults with Down Syndrome (DS) have a substantially increased risk for Alzheimer’s disease (AD) due to the triplicated amyloid-precursor-protein gene on chromosome 21, resulting in amyloid and tau accumulation. However, tau PET assessments are not sufficiently implemented in DS-AD research or clinical work-up, and second-generation tau tracers such as [18F]PI-2620 have not been thoroughly characterized in adults with DS. We aim at illustrating feasibility and potential diagnostic value of tau PET imaging with [18F]PI-2620 for the diagnosis of DS-AD.Materials and methodsFive adults with DS (40% female, aged 43–62) and cognitive decline underwent clinical assessments, neuropsychological testing, lumbar puncture and multimodal neuroimaging. All underwent [18F]PI-2620 tau PET. Visual read of tau PET scans was performed by three blinded raters, assessing increased tracer uptake in brain areas corresponding to the six Braak stage regions and basal ganglia.ResultsVisual read of tau burden revealed three tau-positive individuals which corresponded to their clinical decline while two cognitively stable individuals were rated as negative. Rating showed high inter-rater reliability for all Braak stages.ConclusionTau PET imaging is a feasible and important biomarker assessment in the differential diagnosis of cognitive decline in adults with DS at risk of developing AD.
The effect of Coriandrum sativum L. on yogurt: a comprehensive study of physicochemical, microbiological, sensory, and textural properties
Authors: Turgut Tamer , Diler Abdulkerim 
Published: January 2025

ObjectivesThe objective of this study was to investigate the effects of the addition of Coriandrum sativum L. (coriander) on the physicochemical, sensory, textural and microbiological properties of yogurt.MethodsTo conduct this study, 4 types of yogurt were prepared as control (C0) and with 1% (C1), 2% (C2) and 3% (C3) coriander, and the yogurts were analyzed on specific storage days.ResultsThe addition of coriander significantly influenced some physiochemical parameters (syneresis, titratable acidity) of yogurts (p &lt; 0.05). The storage time significantly affected the water holding capacity (WHC), syneresis and titratable acidity (TA). The TA of the yogurts increased during storage. The addition of coriander significantly influenced the color parameters (ΔE, C* and YI) of yogurts (p &lt; 0.05). The results of the statistical analysis indicated that storage time had a significant effect on the viability of yogurt bacteria (p &lt; 0.05). While the number of Lactobacillus bulgaricus decreased, an increase was observed in the number of Streptococcus thermophilus. The number of both yogurt bacteria remained above 7.46 log cfu/g throughout storage. The addition of coriander to yogurt led to changes in the number of yogurt bacteria. When the texture parameters of the yogurts were compared, no significant difference was seen between the yogurts. The sensory evaluation showed that yogurts with coriander had a higher overall acceptability than C0 yogurts.ConclusionThe results of the research indicate that the addition of coriander has a positive effect on the quality of yogurt. The results of this study suggest that the inclusion of coriander and other similar aromatic plants in yogurt production could be beneficial in terms of producing functional yogurt and the potential uses of these plants should be investigated.
Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women
Authors: Greed Elsa , Pritchard Jack , Struszczak Lauren , Bozbaş Esra , Ek Georgia , Acheson Jordan , Winney Ben , Qadir Aaliyah , Wong Karl Ka-Lam , Bowtell Joanna , O’Leary Mary 
Published: January 2025

IntroductionShatavari is a herbal dietary supplement that may increase skeletal muscle strength in younger and older adults. Shatavari contains compounds with both estradiol-like and antioxidant properties, which could enhance muscle function. Postmenopausal women may derive the greatest benefit, as estrogen deficiency adversely impacts skeletal muscle function. However, mechanistic insights are limited and the effects of shatavari on muscle function require further characterization.MethodsIn this randomized, double-blind trial, 17 young (23 ± 5 yr) and 22 older (63 ± 5 yr) women completed an 8-week leg resistance training programme. They consumed either a placebo or shatavari (1000 mg/d, equivalent to 26,500 mg/d fresh weight) supplement throughout. Pre and post training, measures of leg strength, neuromuscular function and vastus lateralis (VL) biopsies were obtained. Tandem-mass-tagged VL proteomic analyses were performed. Data were analyzed using a differential expression (Reactome) approach.ResultsShatavari supplementation increased 8-week training load in older women (leg press repetitions completed, p = 0.049, ηp2 = 0.198; maximum weight lifted each week, p = 0.03, ηp2 = 0.386; ANCOVA). There was no effect of shatavari on muscle strength post-training. VL half relaxation time was shortened post-training in older women supplemented with shatavari (post-training change: shatavari −11.74 ± 11.93%, placebo 0.42 ± 14.73%, p = 0.021; ANCOVA). Shatavari supplementation diminished the expression of extracellular matrix proteins in both cohorts. Expression of proteins related to striated muscle contraction, transcription and translation were decreased by shatavari supplementation in older women.DiscussionThese novel observations support the notion that shatavari supplementation confers resistance to neuromuscular fatigue in older women. This could ameliorate sarcopenic declines in skeletal muscle function.
International diet quality index and revised diet quality index relationship with type 2 diabetes disease: a case-control study
Authors: El-Sehrawy Amr Ali Mohamed Abdelgawwad , Mukhlif Bilal AbdulMajeed , Oghenemaro Enwa Felix , Rekha M. M. , Kumawat Rohit , Sharma Shilpa , Kumar M. Ravi , Shalaby Nagat Salah , Abosaoda Munthar Kadhim , Kadhim Abed J. 
Published: January 2025

BackgroundType 2 diabetes mellitus (T2DM) is a global health crisis linked to increased cardiovascular risk. Research indicates that better dietary quality—higher intake of fruits, vegetables, and whole grains, and lower intake of processed foods—reduces T2DM risk. This study examines the relationship between T2DM and dietary quality indices (DQI-I and DQI-R) to determine if adherence can lower diabetes risk. By analyzing dietary patterns in individuals with and without diabetes, the research aims to identify key nutritional factors influencing disease risk and provide evidence-based dietary recommendations for prevention and management.MethodsThis case-control study involved 128 T2DM patients and 256 controls, assessing dietary intake with a validated 168-item food frequency questionnaire to calculate the Dietary Quality Index-I (DQI-I) and Dietary Quality Index-R (DQI-R). Multivariable logistic regression analysis explored the relationship between DQI-I, DQI-R, and their components with T2DM development odds.ResultsThe mean (SD) age and body mass index (BMI) of participants, comprising 53.7% men, were 37.8 (7.8) years and 27.7 (3.3) kg/m2, respectively. In the final model, each standard deviation increase in the DQI-I score was associated with reduced odds of T2DM (odds ratio [OR] = 0.61; 95% confidence interval [CI] = 0.37–0.92; p = 0.046). Among the components of the DQI-I, a high adequacy score was significantly correlated with lower odds of T2DM (OR = 0.13; 95% CI = 0.05–0.36; p &lt; 0.001). Additionally, participants in the highest tertile of the DQI-R score exhibited lower odds of T2DM compared to those in the lowest tertile (OR = 0.29; 95% CI = 0.11–0.49; p &lt; 0.001). Furthermore, within the components of the DQI-R, a high moderation score was associated with a decreased risk of T2DM (OR = 0.19; 95% CI = 0.09–0.45; p &lt; 0.001).ConclusionThe case-control study suggests a potential protective effect of diets with higher scores on the Diet Quality Index-International (DQI-I) and Revised Diet Quality Index (DQI-R) in reducing T2DM risk. Future research should focus on larger sample sizes and prospective designs to further investigate the DQI-I, DQI-R, and their components in relation to T2DM and other chronic diseases.
NutriBase – management system for the integration and interoperability of food- and nutrition-related data and knowledge
Authors: Valenčič Eva , Beckett Emma , Bucher Tamara , Collins Clare E. , Koroušić Seljak Barbara 
Published: January 2025

IntroductionContemporary data and knowledge management and exploration are challenging due to regular releases, updates, and different types and formats. In the food and nutrition domain, solutions for integrating such data and knowledge with respect to the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles are still lacking.MethodsTo address this issue, we have developed a data and knowledge management system called NutriBase, which supports the compilation of a food composition database and its integration with evidence-based knowledge. This research is a novel contribution because it allows for the interconnection and complementation of food composition data with knowledge and takes what has been done in the past a step further by enabling the integration of knowledge. NutriBase focuses on two important challenges; data (semantic) harmonization by using the existing ontologies, and reducing missing data by semi-automatic data imputation made from conflating with existing databases.Results and discussionThe developed web-based tool is highly modifiable and can be further customized to meet national or international requirements. It can help create and maintain the quality management system needed to assure data quality. Newly generated data and knowledge can continuously be added, as interoperability with other systems is enabled. The tool is intended for use by domain experts, food compilers, and researchers who can add and edit food-relevant data and knowledge. However, the tool is also accessible to food manufacturers, who can regularly update information about their products and thus give consumers access to current data. Moreover, the traceability of the data and knowledge provenance allows the compilation of a trustworthy management system. The system is designed to allow easy integration of data from different sources, which enables data borrowing and reduction of missing data. In this paper, the feasibility of NutriBase is demonstrated on Slovenian food-related data and knowledge, which is further linked with international resources. Outputs such as matched food components and food classifications have been integrated into semantic resources that are currently under development in various international projects.
The effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with T2DM: a meta-analysis of randomized controlled trials
Authors: Tian Wende , Cao Shuyu , Guan Yongxin , Zhang Zihao , Liu Qiyu , Ju Jianqing , Xi Ruixi , Bai Ruina 
Published: January 2025

BackgroundThe dual burden of Type 2 Diabetes Mellitus (T2DM) and obesity is a critical public health issue. Low-carbohydrate diets have emerged as a potential intervention, yet clinical evidence remains inconclusive.PurposeThis meta-analysis assesses the impact of low-carbohydrate diets on metabolic profiles in overweight or obese T2DM patients, aiming to guide clinical practice.MethodsA systematic review identified randomized clinical trials (RCTs) comparing low-carbohydrate diets to control diets in T2DM patients from PubMed, Embase, and the Cochrane Library databases up to April 2023.ResultsSeventeen RCTs, encompassing 1,197 participants, demonstrated that low-carbohydrate diets significantly improved HbA1c levels and fasting plasma glucose (mean difference [MD] = −0.36, 95% CI −0.44 to −0.29, p &lt; 0.00001; MD = −10.71, 95% CI −14.39 to −7.03, p &lt; 0.00001). They also reduced triglycerides and increased HDL cholesterol (MD = −19.91, 95% CI −28.83 to −10.99, p &lt; 0.00001; MD = 2.49, 95% CI 1.07–3.91, p = 0.0006), without affecting LDL and total cholesterol. Weight loss, reduced BMI, lower diastolic blood pressure, and decreased waist circumference were additional benefits.ConclusionLow-carbohydrate diets may enhance glycemic control and lipid profiles in overweight or obese T2DM patients, warranting consideration in T2DM management. However, the variability in diet definitions and methodologies underscores the necessity for further research to standardize dietary guidelines and evaluate long-term effects.
Outcome of critically ill patients receiving systemic chemotherapy on the intensive care unit
Authors: Karagiannis Panagiotis , Klingler Felix , Arelin Viktor , Alsdorf Winfried , König Christina , Roedl Kevin , Fiedler Walter , Weisel Katja , Kluge Stefan , Bokemeyer Carsten , Wichmann Dominic 
Published: January 2025

ObjectiveAnalyze the outcomes of critically ill patients who developed new-onset organ dysfunction and received systemic chemotherapy during their ICU stay.DesignRetrospective cohort study.SettingA tertiary medical center in Germany with an Intensive Care Medicine department consists of 11 intensive care units comprising 140 beds, serving all subspecialties of adult intensive care medicine.Patients167 patients receiving systemic oncological treatment from January 1st, 2015 to December 31st, 2021, with a data cut-off on December 31st, 2022.InterventionsNone.Measurements and main resultsA total of 167 patients were included. The primary reasons for ICU admission were respiratory failure and shock/sepsis, each accounting for 34% of cases, while complications associated with oncological therapy accounted for less than 8%. The median age of hematological patients (n = 129) was 62 years (IQR 50–70), and for solid tumor patients (n = 38), it was 60 years (IQR 52–65). Predominant disease entities included lymphoma (43%) and acute myeloid leukemia (29%) among hematological patients, and lung cancer (47%) and gastrointestinal malignancies (17%) among solid tumor patients. Hematological patients had a significantly higher median Simplified Acute Physiology Score II (47 vs. 39 points; p=0.013), a higher need for invasive mechanical ventilation (59% vs. 50%; p=0.3), renal replacement therapy (54% vs. 24%; p &lt; 0.001), and a higher 1-year mortality rate (64% vs. 53%; p=0.2) compared to solid tumor patients. The hazard ratio for 1 year survival for male sex was 2.34 (1.31–3.49), for mechanical ventilation 2.01 (1.33–3.04), for vasopressor therapy 1.98 (1.27–3.10), and for renal replacement therapy 1.51 (1.03–2.23), respectively.ConclusionAdministering intravenous chemotherapy in an ICU setting remains challenging, and the experience to establish an indication for systemic chemotherapy is still challenging. However, the study demonstrates that, after careful interdisciplinary decision-making, a substantial number of patients can benefit from it.
Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway
Authors: Dai Guanqi , Lin Junhao , Jiang Yuchuan , Liu Xinhui , Chen Peng , Zhang Yixiao , Song Zhenghui , Zhuang Xuefen , Cong Jinge , Li Yingchun , Hong Xuanjia , Liu Yun , Xiao Dong , Li Aimin , Luo Yue 
Published: January 2025

AimsAurora kinase A (AURKA) has been implicated in promoting myeloid and renal fibrosis. This study aimed to investigate the impact and underlying mechanism of AURKA on liver fibrosis and to assess the therapeutic potential of MLN8237, a small-molecule AURKA inhibitor, in preventing liver fibrosis in mice.MethodsThe research used bioinformatics analysis and immunohistochemistry staining on fibrotic liver tissues from human and mouse models to assess AURKA expression. The cellular localization of AURKA was determined through double immunofluorescence staining in human fibrotic liver tissues and primary mouse hepatic stellate cells. RNA interference and AURKA antagonism were used to examine the effects of AURKA on liver fibrosis, while RNA-sequencing, qRT-PCR, and western blotting were employed to elucidate the potential molecular mechanisms of AURKA on hepatic stellate cell activation.ResultsThe results showed that AURKA was positively correlated with the progression of liver fibrosis and was predominantly expressed in activated HSCs. Silencing AURKA inhibited HSC activation and proliferation, and induced HSC apoptosis, effects that were similar to those observed with MLN8237 treatment. Additionally, silencing AURKA suppressed the glycogen synthase kinase-3β/β-catenin signaling pathway. Pharmacological inhibition of AURKA phosphorylation also resulted in reduced liver fibrosis in vivo.ConclusionIn conclusion, AURKA may promote HSC activation and liver fibrosis through the Wnt/β-catenin pathway, suggesting its potential as a therapeutic target for liver fibrosis.
Robot-assisted laparoscopic ipsilateral ureteroureterostomy for duplex kidneys in children: preliminary single-center experience
Authors: Yang Chao , Zhang Chi , Cao Yongsheng , Deng Qi-fei , Mao Changkun 
Published: January 2025

ObjectiveThis study evaluates the efficacy and safety of robot-assisted laparoscopic ipsilateral ureteroureterostomy (RAL-IUU) in treating children with duplex kidney ureteral malformations by detailing our early single-center experience.Materials and methodsWe conducted a retrospective analysis of clinical data from 14 children with complete duplex kidney ureteral malformations treated with RAL-IUU at our institution from December 2021 to January 2024. Clinical data included patient demographics, surgical details, and postoperative outcomes.ResultsThe operation time averaged 128.71 ± 22.35 min in 14 cases, intraoperative blood loss was 7.57 ± 2.77 ml, drainage tube placement lasted for 3.14 ± 0.66 days, and hospital stay averaged 4.79 ± 0.70 days. Stent placement lasted 43.58 ± 6.33 days. Notable changes were observed in the upper moiety anterior-posterior diameter (APD) before and after surgery (23.84 ± 8.05 mm vs. 6.71 ± 2.20 mm, P &lt; 0.001), diameter at the widest part of the upper moiety ureter (15.58 ± 6.07 mm vs. 4.61 ± 0.78 mm, P &lt; 0.001), and split renal function of the upper moiety (12.28 ± 3.04% vs. 16.50 ± 2.75%, P &lt; 0.001). Postoperative follow-up ranged from 6 to 18 months; during the period with a D-J stent, one case developed a urinary tract infection, one case had recurrent gross hematuria, and another child exhibited significant urinary irritative symptoms (frequency), with an abdominal plain film revealing that the D-J tube had descended completely into the bladder, and symptoms disappeared after the removal of the D-J tube. During the follow-up period post-D-J tube removal, none of the 14 children experienced a urinary tract infection again during the follow up period, urinary incontinence ceased.ConclusionRAL-IUU provides an excellent surgical field and operating space, precise suturing, and minimal surgical trauma. Postoperatively, there is a reduction in renal pelvis and ureteral hydronephrosis, recovery of split renal function, and minimal complications all with rapid recovery. RAL-IUU is a safe and feasible treatment option for children with complete duplex kidneys.
Endoscopic retrograde cholangiopancreatography in children with pediatric congenital biliary dilatation associated with pancreatobiliary maljunction: experience from a tertiary center
Authors: Rollo Giovanni , Balassone Valerio , Faraci Simona , Torroni Filippo , Dall'Oglio Luigi , De Angelis Paola , Caldaro Tamara 
Published: January 2025

BackgroundCongenital biliary dilatation (CBD) is a congenital malformation of the main biliary tract usually associated with the pancreatobiliary maljunction (PBM), determining stone formation, cholangitis, pancreatitis, and cholangiocarcinoma. The role of endoscopic retrograde cholangiopancreatography (ERCP) in treatment and diagnosis has not been established yet. Therefore, the aim of our study is to define the actual role of ERCP in children with CBD.MethodsA retrospective review of consecutive patients with congenital biliary dilatation undergoing preoperative ERCP and subsequent surgical treatment at our pediatric tertiary referral center (Endoscopy and Digestive Surgery, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy) was performed between 2012 and 2023.ResultsA total of 31 patients were included in the present study. Preoperative ERCP detected a PBM in 28 patients (90%). According to Todani's classification, 2 patients (6.5%) had choledochal cyst (CC) type IV, and 29 patients (93.5%) were diagnosed with CC type I. In 18 (58%) patients, ERCP was performed for treating acute pancreatitis. Sphincterotomy could be performed in 23 of 31 (74%) patients. Patients who did not undergo sphincterotomy had a higher number of acute episodes while awaiting surgery.ConclusionsThe present study is supportive of an essential role of ERCP in the diagnostic and preoperative management of children with CBD with acute presentation or inconclusive magnetic resonance cholangiopancreatography findings.