bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the antifungal effect of chlorogenic acid against strains of Candida spp. resistant to fluconazole: apoptosis induction and in silico analysis of the possible mechanisms of action
Authors: Rocha da Silva Cecília , Sá Lívia Gurgel do Amaral Valente , dos Santos Ermerson Vieira , Ferreira Thais Lima , Coutinho Tatiana do Nascimento Paiva , Moreira Lara Elloyse Almeida , de Sousa Campos Rosana , de Andrade Claudia Roberta , Barbosa da Silva Wildson Max , de Sá Carneiro Igor , Silva Jacilene , dos Santos Hélcio Silva , Marinho Emmanuel Silva , Cavalcanti Bruno Coelho , de Moraes Manoel Odorico , Júnior Hélio Vitoriano Nobre , Andrade Neto João Batista 
Published: May 2022

Introduction.Candidaspp. are commensal fungal pathogens of humans, but when there is an imbalance in the microbiota, or weak host immunity, these yeasts can become pathogenic, generating high medical costs.Gap Statement.With the increase in resistance to conventional antifungals, the development of new therapeutic strategies is necessary.This study evaluated thein vitroantifungal activity of chlorogenic acid against fluconazole-resistant strains ofCandidaspp.Mechanism of action through flow cytometry andin silicoanalyses, as well as molecular docking assays with ALS3 and SAP5, important proteins in the pathogenesis ofCandida albicansassociated with the adhesion process and biofilm formation.Results.The chlorogenic acid showedin vitroantifungal activity against the strains tested, causing reduced cell viability, increased potential for mitochondrial depolarization and production of reactive oxygen species, DNA fragmentation and phosphatidylserine externalization, indicating an apoptotic process. Concerning the analysis through docking, the complexes formed between chlorogenic acid and the targetsThymidylate Kinase, CYP51, 1Yeast Cytochrome BC1 ComplexeExo-B-(1,3)-glucanasedemonstrated more favourable binding energy. In addition, chlorogenic acid presented significant interactions with the ALS3 active site residues ofC. albicans,important in the adhesion process and resistance to fluconazole. Regarding molecular docking with SAP5, no significant interactions were found between chlorogenic acid and the active site of the enzyme.Conclusion.We concluded that chlorogenic acid has potential use as an adjuvant in antifungal therapies, due to its anti-Candidaactivity and ability to interact with important drug targets.
A nexus between intra-ASEAN outward FDI, intra-ASEAN exports and economic growth of ASEAN-10: evidence using panel causality analysis
Authors: Wong Koi Nyen , Tan Bee Wah , Goh Soo Khoon 
Published: May 2022

PurposeThe Association of Southeast Asian Nations (ASEAN) has evolved into ASEAN Economic Community (AEC), which aims to pursue a single market and production base to transform ASEAN into a dynamic, competitive and global region. ASEAN is inherently heterogeneous that potentially could promote further economic integration, fundamentally, through the interactions between intra-regional outward foreign direct investment (OFDI), export trade and economic growth. Hence, this paper attempts to explore the causal relationship between intra-ASEAN OFDI, intra-ASEAN exports and economic growth of ASEAN-10 countries.Design/methodology/approachThis paper attempts to explore the causal relationship between intra-ASEAN OFDI, intra-ASEAN exports and economic growth of ASEAN-10 countries, using regional panel data based on Dumitrescu and Hurlin (2012) non-causality analysis, which allows us to take into account of the heterogeneity in terms of causal relationships.FindingsThe empirical study shows bidirectional causality between intra-ASEAN export and intra-ASEAN OFDI, a bidirectional causality between intra-ASEAN export trade and intra-ASEAN economic growth and a unidirectional causality running from the real GDP of ASEAN-10 countries to intra-ASEAN OFDI.Research limitations/implicationsThe findings have implications for the extent of intra-ASEAN production fragmentation, policy formulations for furthering intra-regional OFDI, and trade to achieve the ASEAN integration agenda.Originality/valueThe main contribution of the current study is to use the panel causality analysis for an emerging dynamic region, specifically, the AEC. As far as we know, this is the first study ascertaining whether there is a causality relationship between intra-ASEAN OFDI, intra-ASEAN export trade and economic growth of ASEAN-10, which is a longstanding objective of ASEAN integration agenda.
Intellectual capital and bank performance: the moderating role of income diversification
Authors: Githaiga Peter Nderitu 
Published: May 2022

PurposeThis study examines whether income diversification moderates the relationship between intellectual capital and bank performance among East African banks.Design/methodology/approachThe study uses a sample of 53 East African banks and a panel dataset for the period 2010–2018. The hypotheses are tested through a hierarchical regression model.FindingsThe regression results indicate that intellectual capital (IC) significantly affects bank performance. Further, the study finds that income diversification has a negative and significant effect on bank performance. The results indicate that income diversification reduced the overall impact of IC (Value Added Intellectual Capital (VAIC)) efficiency on bank performance for the moderating influence. However, the moderating role of income diversification on the relationship between individual components of VAIC (HCE, SCE and CEE) varies. While income diversification enhanced the impact of structural capital efficiency (SCE) on bank performance, it also reduced the effect of human capital efficiency (HCE). Additionally, income diversification did not moderate the impact of capital employed efficiency (CEE) on bank performance.Originality/valueThis study contributes to the literature by demonstrating that non-traditional banking activities influence the IC and bank performance relationship, which is scanty in the existing literature.
Do normative triggers and motivations influence the intention to purchase organic food? An application of the goal-framing theory
Authors: Khan Kamran , Hameed Irfan , Akram Umair , Hussainy Syed Karamatullah 
Published: May 2022

PurposeHuman health, food safety and environmental concerns are growing issues for policymakers, firms and the general public. Food without chemicals and pesticides is healthy for the human body and hence, relevant motives to promote organic food consumption needs to be explored. This study used three motivational factors, i.e. hedonic, gain and normative motivations proposed by goal-framing theory (GFT) that affect sustainable consumption. Considering the local scenario, constructs like normative triggers and knowledge have also been incorporated into the model. Therefore, this study attempts to explore whether normative triggers and motivations influence the intention to purchase organic food with the application of GFT Design/methodology/approachData were collected from 467 consumers using the purposive sampling technique. The span of the collection of data collection was around five months. Partial least square structural equation modeling (PLS-SEM) has been applied and after checking the validity and reliability indicators, bootstrapping has been used for hypotheses testing.FindingsAll the motivational factors were found significant and positive to consumers' intentions toward organic food. Moreover, normative triggers also influence intentions. The construct knowledge was not found in a direct relationship with intentions; however, a moderating role was established between gain motivations and intentions.Research limitations/implicationsThe study validated and extended the concepts presented in the GFT. Motivational constructs were found important and can be implied in low-cost product categories. The policymakers are suggested to take appropriate measures, based on empirical results.Originality/valueThe study provides an understanding of motivational factors, normative triggers and knowledge in the organic food consumption extent. This will help administrative authorities, marketers and producers of organic food in making their policies, communication strategies and production preferences.
Rice farmers’ perceptions and response to climate variability, and determinants of adaptation strategies in the Republic of Benin
Authors: Gbemavo Charlemagne Dossou Seblodo Judes , Toffa Joelle , Tchakpa Cyrille , Loko Yêyinou Laura Estelle , Djedatin Gustave , Ewedje Eben-Ezer , Orobiyi Azize , Sedah Paulin , Sabot Francois 
Published: May 2022

Purpose
The purpose of this study is to evaluate rice farmers’ perceptions on the manifestations of the climate change and identify efficient strategies and determinants of adoption of these strategies in the Republic of Benin.

Design/methodology/approach
Surveys were conducted using participatory research appraisal tools and techniques, such as direct observation, individual interviews and field visits through a questionnaire for data collection. A total of 418 rice farmers across 39 villages located in the three climatic zones of the Republic of Benin were interviewed. Farmers’ perceptions, temperature from 1952 to 2018 and rainfall from 1960 to 2018 data obtained from meteorological stations were analysed using descriptive and inferences statistics.

Findings
All the surveyed farmers were aware of climate change and perceived diverse manifestations including the delay in rainfall regarded as the most important risk. They perceived that deforestation, no respect for the laws of nature and desacralization of morals, no respect for cultures and the traditional rainmakers are the main causes of climate change. The disruption of agricultural calendar and the reduction in rice yield were perceived as the main impacts of climate change in rice production. They used various approaches to adapt and mitigate climate change effects. The adoption of adaptation strategies was influenced either negatively or positively by the household size, land size, education level, membership to rice farmer’s association, training in rice production, access to extension services, use of improved varieties and the location in climatic zones.

Research limitations/implications
For each climatic zone of the Republic of Benin, weather data were collected in only one meteorological station.

Practical implications
The study showed that it is important to educate rice farmers on the scientific causes of climate change for better resilience. There is an urgent need to train rice farmers in irrigation and water management techniques to cope with climate variability. To promote irrigation, the authors suggest the establishment of a subsidy and credit mechanism by the government. Factors that influenced adoption of efficient adaptation strategies to climate events must be taken into account for future adaptation policies in the Republic of Benin.

Originality/value
This study provided an overview of the perceptions and adaptations of rice farmers along the climatic gradient in the Republic of Benin. Therefore, the knowledge of the determining factors of the adaptation strategies used by rice farmers could be used in the setting up of effective climate change resilience policies in Benin.
The interaction effects of congruence type, assessment perspective and social distance on visit intention
Authors: Wang Li , Shen Xiangdong , Yan Lei , Li Pengfei 
Published: May 2022

Purpose
The purpose of this study is to explore the three-way interaction effects among congruence type (proximal vs distal) of nonverbal ad messages, assessment perspective (internal vs external) of verbal ad messages and social distance (close vs faraway) on consumers’ visit intention.

Design/methodology/approach
After developing the four categories of restaurant advertisements and scenarios for each type of social distance, the authors used 780 observations collected from Chinese consumers via the online survey platform Sojump and WeChat. The authors conducted ANOVA to test the hypotheses.

Findings
The results reveal that in proximal congruence situations, consumers who feel a close social distance between themselves and their companions report higher visit intentions when exposed to internal versus external perspective-oriented ad messages; in distal congruence situations, external perspective-oriented ad messages elicit higher intention to visit advertised restaurant when consumers feel a far social distance between themselves and their companions.

Research limitations/implications
Future research can focus on the different categories of messages, such as functional and experiential messages, to find whether similar interaction effects are explored or not.

Practical implications
This paper suggests some practical implications for advertisers to maximize the impact of advertisements on consumers’ behavioral outcomes via combining the different characteristics of nonverbal and verbal messages effectively, especially according to their target consumers’ characteristics.

Originality/value
In the view of the three-way interaction effects, this paper offers a new lens on understanding how advertisements influence consumers’ behavioral outcomes, which could contribute to the advancement of advertisement theories.
Outcomes of environmental awareness
Authors: Bouzari Mona , Safavi Homayoun Pasha , Foroutan Taraneh 
Published: May 2022

Purpose
Grounded on the collected data and basic view of the belief-action-outcome, the current study aims to investigate the mediating role of environmental commitment (EC) in the relationship between environmental awareness (EA) and three outcomes, namely, pro-environmental behavior (PEB), willingness to sacrifice for the environment (WSE) and nongreen behaviors (NGB).

Design/methodology/approach
Data was gathered from 509 restaurant employees and 96 supervisors in two different waves through a 10-day time lag in India. Structural equation modeling was used to understand the relationships using LISREL 8.30.

Findings
This study verified that employees’ EA is significantly related to EC. Moreover, according to the results, employees’ EC is positively related to PEB and WSE while it is negatively related to NGB. The results similarly attested to the mediation impact of EC in the relationship between EA and the outcomes.

Research limitations/implications
Organizations’ employment of green and eco-friendly practices can make employees more familiar with environmental concepts and practices. The current study encourages restaurant managers to regularly invest and be involved in developing relevant environmental training, which can improve employees’ knowledge and awareness of environmental matters.

Originality/value
By highlighting overlooked concerns in the restaurant and service literature, the current study makes significant contributions in the context of the restaurant industry. To date, there is not a single indication of any study that analyzes the impact of EA on employee EC and its potential links to other employee outcomes.
Stakeholder analysis and landscape in a hospital project – elements and implications for value creation
Authors: Tampio Kari-Pekka , Haapasalo Harri , Ali Farooq 
Published: May 2022

PurposeThis study primarily aims to analyse stakeholder management challenges and how these emerge in the stakeholder landscape in a large hospital project. From this analysis, the authors aim to identify the implications that stakeholder management has on value creation in a hospital project.Design/methodology/approachThe research method is qualitative. Empirical data were collected in three cycles: project internal documentation, thematic interviews and survey. The literature related to hospital projects, stakeholder analysis and management, stakeholder salience and landscape is summarised, informing the qualitative design of the study.FindingsThe authors noted the importance of project-specific stakeholder identification, salience analysis and landscape description. The regulatory, formal and contractual stakeholders give an over-simplistic picture on stakeholder map. The operative stakeholder map and landscape describe the complexity, uncertainty, dynamism and institutional context inducing the challenges for the stakeholder management. There is an evident potential of utilising the stakeholder landscape and its elements in the resulting collaborative value creation in hospital projects. Multiple and changing stakeholders with differing expectations are an important opportunity to improve the value creation process.Originality/valueStakeholder management has recently attracted much attention in the industrial project setting. This research attempts to identify the operative stakeholder landscape in a large hospital project, not to mention its impact on value creation. This study offers a framework that can help academics and project management practitioners tackle the challenges amongst project stakeholders.
Exploring the role of augmented reality in online impulse behaviour
Authors: Kumar Harish , Srivastava Ritu 
Published: May 2022

PurposeThis study aims to examine the role of augmented reality (AR) in online impulse behaviour for highbody-involvement products. This study further explores whether flow and spatial presence mediate the link between AR and online impulse behaviour.Design/methodology/approachThe authors collected 255 responses from shopping mall visitors and used SPSS (21.0) (PROCESS macro) and AMOS 21.0 to test the hypothesised model.FindingsThe findings reveal that AR virtual try-on significantly influences online impulse behaviour by providing hedonic value and reducing product risk prior to purchase. Second, flow and spatial presence partially and complementarily mediate the relationship between AR characteristics, hedonic value, and product risk.Originality/valueTheoretically, this study extends the literature on AR and online impulse behaviour from a psychological perspective, and it broadens managers' understanding of how they can use AR as a tool to increase sales.
Model-based detection and isolation of the wheel slippage and actuator faults of a holonomic mobile robot
Authors: Şahin Osman Nuri , Dede Mehmet İsmet Can 
Published: May 2022

Purpose
Mobile robots may perform very critical tasks under difficult operating conditions. Faults encountered during their tasks may cause the task to be interrupted or failed completely. In the active fault tolerant control methods, it is very important not only to detect the faults that occur in the robot, but also to isolate these faults to develop a fault recovery strategy that is suitable for that specific type of fault. This study aims to develop a model-based fault detection and isolation method for wheel slippage and motor performance degradation that may occur in wheeled mobile robots.

Design/methodology/approach
In the proposed method, wheel speeds can be estimated via the dynamic model of the mobile robot, which includes a friction model between the wheel and the ground. Four residual signals are obtained from the differences between the estimated states and the measured states of the mobile robot. Mobile robot’s faults are detected by using these signals. Also, two different residual signals are generated from the calculation of the traction forces with two different procedures. These six residual signals are then used to isolate possible wheel slippage and performance degradation in a motor.

Findings
The proposed method for diagnosing wheel slip and performance degradation in motors are tested by moving the robot in various directions. According to the data obtained from the test results, a logic table is created to isolate these two faults from each other. Thanks to the created logic table, slippage in any wheel and performance degradation in any motor can be detected and isolated.

Originality/value
Two different recovery strategies are needed to recover temporary wheel slippage and permanent motor faults. Therefore, it is important to isolate these two faults that create similar symptoms in robot’s general movement. Thanks to the method proposed in this study, it is not only possible to isolate the slipping wheel with respect to the non-slipping wheels or to isolate the faulty motor from the non-faulty ones, but also to isolate these two different fault types from each other.
Designing for circularity: sustainable pathways for Australian fashion small to medium enterprises
Authors: Piller Lisa Westover 
Published: May 2022

PurposeAustralians consume twice the global average of textiles and are deeply engaged in a linear take/make/waste fashion model. Furthermore the Australian fashion sector has some unique supply chain complications of geographical distances, sparse population and fragmentation in processing and manufacturing. This research aims to examine how Australian fashion small to medium enterprises (SMEs) are overcoming these challenges to run fashion businesses built around core principles of product stewardship (PS) and circularity.Design/methodology/approachSMEs make up 88% of the Australian apparel manufacturing sector. This qualitative exploratory study included in-depth interviews with three Australian fashion SMEs engaged in circular design practice, and a focus group of 10 Western Australian fashion advocates of sustainability. Analytic coding and analysis of the data developed eight distinct themes.FindingsThis study examines the barriers to circular economy (CE) that exist in the Australian fashion sector, and maps the practice of Australian SMEs with circular business models in overcoming these barriers. In CE innovation, Australian SMEs may have an advantage over larger fashion companies with more unwieldy structures. Employing design-thinking strategies, Australian SMEs with a foundation of PS and circular purpose are creating new systems of viable closed-loop business models and design processes.Originality/valueThe themes from this research contribute to the limited literature on circular innovation examples that link CE theory with practice in the fashion sector. The model for circularity maps the practice of three SMEs built around core principles of PS and circularity in overcoming the barriers to CE in an Australian context, and may be used as a visual tool in education and understanding.