bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tumor core boost study: A feasibility study of radical dose escalation to the central part of large tumors with an integrated boost in the palliative treatment setting
Authors: Wittenstein Olaf , Krause Fabian , Fischer Mirko , Domschikowski Justus , Nitsche Mirko , Henkenberens Christoph , Habermehl Daniel , Dunst Juergen 
Published: July 2022

Abstract
Purpose
For patients with large tumors palliative radiotherapy often is the only local treatment option. To prevent toxicity the administered doses are low. Dose escalation to the tumor could be an option to better smyptom control and prolong local control rates. In this prospective study we used a very pragmatic approach with a simultaneously integrated boost (SIB) to an almost geometrically defined tumor core to achieve this. The primary endpoint was to demonstrate feasibility.

Method
Patients with solid tumors > 4 cm in diameter of different histologies were eligible in this single arm, prospective, multi-institutional clinical feasibility trial with two treatment concepts: 5 × 5 Gy with an integrated boost to the tumor core of 5 × 10 Gy or 10 × 3 Gy with a boost of 10 × 6 Gy. The objective of dose escalation in this study was to deliver a minimum dose of 150% of the prescribed dose to the gross tumor volume (GTV) tumor core and to reach a maximum of at least 200% in the tumor core.

Results
In all, 21 patients at three study sites were recruited between January 2019 and November 2020 and were almost evenly spread (9 to 12) between the two concepts. The treated planning target volumes (PTV) averaged 389.42 cm3 (range 49.4–1179.6 cm3). The corresponding core volumes were 72.85 cm3 on average (range 4.21–338.3 cm3). Dose escalation to the tumor core with mean doses of 167.7–207.7% related to the nonboost prescribed isodose led to PTV mean doses of 120.5–163.3%. Treatment delivery and short-term follow-up was successful in all patients.

Conclusions
Palliative radiotherapy with SIB to the tumor core seems to be a feasible and well-tolerated treatment concept for large tumors. The applied high doses of up to 50 Gy in 5 fractions (or 60 Gy in 10 fractions) did not cause unexpected side effects in the 42 day follow-up period. Further research is needed for more information on efficacy and long-term toxicity.
A note on Bridgeland moduli spaces and moduli spaces of sheaves on $$X_{14}$$ and $$Y_3$$
Authors: Liu Zhiyu , Zhang Shizhuo 
Published: July 2022

AbstractWe study Bridgeland moduli spaces of semistable objects of $$(-1)$$

(
-
1
)

-classes and $$(-4)$$

(
-
4
)

-classes in the Kuznetsov components on index one prime Fano threefold $$X_{4d+2}$$

X

4
d
+
2

of degree $$4d+2$$

4
d
+
2

and index two prime Fano threefold $$Y_d$$

Y
d

of degree d for $$d=3,4,5$$

d
=
3
,
4
,
5

. For every Serre-invariant stability condition on the Kuznetsov components, we show that the moduli spaces of stable objects of $$(-1)$$

(
-
1
)

-classes on $$X_{4d+2}$$

X

4
d
+
2

and $$Y_d$$

Y
d

are isomorphic. We show that moduli spaces of stable objects of $$(-1)$$

(
-
1
)

-classes on $$X_{14}$$

X
14

are realized by Fano surface $$\mathcal {C}(X)$$

C
(
X
)

of conics, moduli spaces of semistable sheaves $$M_X(2,1,6)$$

M
X

(
2
,
1
,
6
)

and $$M_X(2,-1,6)$$

M
X

(
2
,
-
1
,
6
)

and the correspondent moduli spaces on cubic threefold $$Y_3$$

Y
3

are realized by moduli spaces of stable vector bundles $$M^b_Y(2,1,2)$$

M
Y
b

(
2
,
1
,
2
)

and $$M^b_Y(2,-1,2)$$

M
Y
b

(
2
,
-
1
,
2
)

. We show that moduli spaces of semistable objects of $$(-4)$$

(
-
4
)

-classes on $$Y_{d}$$

Y
d

are isomorphic to the moduli spaces of instanton sheaves $$M^{inst}_Y$$

M
Y

inst

when $$d\ne 1,2$$

d
≠
1
,
2

, and show that there are open immersions of $$M^{inst}_Y$$

M
Y

inst

into moduli spaces of semistable objects of $$(-4)$$

(
-
4
)

-classes when $$d=1,2$$

d
=
1
,
2

. Finally, when $$d=3,4,5$$

d
=
3
,
4
,
5

we show that these moduli spaces are all isomorphic to $$M^{ss}_X(2,0,4)$$

M
X

ss

(
2
,
0
,
4
)

.
Angiogenesis in adipose tissue and obesity
Authors: Corvera Silvia , Solivan-Rivera Javier , Yang Loureiro Zinger 
Published: July 2022

AbstractWhile most tissues exhibit their greatest growth during development, adipose tissue is capable of additional massive expansion in adults. Adipose tissue expandability is advantageous when temporarily storing fuel for use during fasting, but becomes pathological upon continuous food intake, leading to obesity and its many comorbidities. The dense vasculature of adipose tissue provides necessary oxygen and nutrients, and supports delivery of fuel to and from adipocytes under fed or fasting conditions. Moreover, the vasculature of adipose tissue comprises a major niche for multipotent progenitor cells, which give rise to new adipocytes and are necessary for tissue repair. Given the multiple, pivotal roles of the adipose tissue vasculature, impairments in angiogenic capacity may underlie obesity-associated diseases such as diabetes and cardiometabolic disease. Exciting new studies on the single-cell and single-nuclei composition of adipose tissues in mouse and humans are providing new insights into mechanisms of adipose tissue angiogenesis. Moreover, new modes of intercellular communication involving micro vesicle and exosome transfer of proteins, nucleic acids and organelles are also being recognized to play key roles. This review focuses on new insights on the cellular and signaling mechanisms underlying adipose tissue angiogenesis, and on their impact on obesity and its pathophysiological consequences.
Sheet sealing in single and multilayer nanopapers
Authors: Ahadian Hamidreza , Sharifi Zamani Elaheh , Phiri Josphat , Coelho Miguel Alexandre Salvador , Maloney Thaddeus 
Published: July 2022

AbstractThis study addresses one of the limiting factors for producing micro and nanofibrillated cellulose (MNFC)-containing papers: poor water removal properties. We focus on the sheet sealing phenomenon during dewatering. A modified dynamic drainage analyzer (DDA) is used to examine both multilayer and single layer forming of MNFC and pulp mixtures. It was found that a thin layer of pulp fibers on the exit layer with the grammage as low as 5 gsm was enough to significantly improve the dewatering of MNFC. For example, the dewatering rate of a furnish with 50% MNFC increased from 0.6 mL/s for a mixed system to 2 mL/s for multilayer system. However, the sheet sealing behavior was completely different when a lower proportion of MNFC was used. For the furnishes with less than 20% MNFC content, the mixed furnishes dewatered faster because the high amount of pulp fibers were able to prevent MNFC from enriching on the exit layer. Surprisingly, we found that very high final solids content (couch solids) could sometimes be achieved when MNFC was used. The highest solids contents achieved were 34 and 29% for the mixed systems. This compares to the 15–20% range typical of standard papermaking furnishes without MNFC. Overall, the results show that contrary to current thinking MNFC containing papers may lead, under some circumstances, to enhanced wire section dewatering.
Growing Out of the Experience: How Subjective Experiences of Effort and Learning Influence the Use of Interleaved Practice
Authors: Onan Erdem , Wiradhany Wisnu , Biwer Felicitas , Janssen Eva M. , de Bruin Anique B. H. 
Published: July 2022

AbstractIn higher education, many students make poor learning strategy decisions. This, in part, results from the counterintuitive nature of effective learning strategies: they enhance long-term learning but also cost high initial effort and appear to not improve learning (immediately). This mixed-method study investigated how students make learning strategy decisions in category learning, and whether students can be supported to make effective strategy decisions through a metacognitive prompt, designed to support accurate monitoring of effort and learning. Participants (N = 150) studied painting styles through blocked and interleaved practice, rated their perceived effort and perceived learning across time, and chose between either blocked or interleaved practice. Half of the participants (N = 74) were provided with a metacognitive prompt that showed them how their subjective experiences per strategy changed across time and required them to relate these experiences to the efficacy of learning strategies. Results indicated that subjective experiences with interleaved practice improved across time: students’ perceived learning increased as their perceived effort decreased. Mediation analysis revealed that the increased feeling of learning increased the likelihood to select interleaved practice. The percentage of students who chose interleaved practice increased from 13 to 40%. Students’ learning strategy decisions, however, did not benefit from the metacognitive prompt. Qualitative results revealed that students initially had inaccurate beliefs about the efficacy of learning strategies, but on-task experiences overrode the influence of prior beliefs in learning strategy decisions. This study suggests that repeated monitoring of effort and learning have the potential to improve the use of interleaved practice.
Filtered Belief Revision: Syntax and Semantics
Authors: Bonanno Giacomo 
Published: July 2022

AbstractIn an earlier paper [Rational choice and AGM belief revision,Artificial Intelligence, 2009] a correspondence was established between the set-theoretic structures of revealed-preference theory (developed in economics) and the syntactic belief revision functions of the AGM theory (developed in philosophy and computer science). In this paper we extend the re-interpretation of those structures in terms of one-shot belief revision by relating them to the trichotomous attitude towards information studied in Garapa (Rev Symb Logic, 1–21, 2020) where information may be either (1) fully accepted or (2) rejected or (3) taken seriously but not fully accepted. We begin by introducing the syntactic notion offiltered belief revisionand providing a characterization of it in terms of a mixture of both AGM revision and contraction. We then establish a correspondence between the proposed notion of filtered belief revision and the above-mentioned set-theoretic structures, interpreted as semanticpartialbelief revision structures. We also provide an interpretation of the trichotomous attitude towards information in terms of the degree of implausibility of the information.
Arbitrary Public Announcement Logic with Memory
Authors: Baltag Alexandru , Özgün Aybüke , Sandoval Ana Lucia Vargas 
Published: July 2022

AbstractWe introduce Arbitrary Public Announcement Logic with Memory (APALM), obtained by adding to the models a ‘memory’ of the initial states, representing the information before any communication took place (“the prior”), and adding to the syntax operators that can access this memory. We show that APALM is recursively axiomatizable (in contrast to the original Arbitrary Public Announcement Logic, for which the corresponding question is still open). We present a complete recursive axiomatization, that includes a natural finitary rule, and study this logic’s expressivity and the appropriate notion of bisimulation. We then examine Group Announcement Logic with Memory (GALM), the extension of APALM obtained by adding to its syntax group announcement operators, and provide a complete finitary axiomatization (again in contrast to the original Group Announcement Logic, for which the only known axiomatization is infinitary). We also show that, in the memory-enhanced context, there is a natural reduction of the so-called coalition announcement modality to group announcements (in contrast to the memory-free case, where this natural translation was shown to be invalid).
Selection of dilution material for non-iodinated iodine as an oral contrast agent for esophageal cancer: a preliminary clinical trial
Authors: Xu Xia , Wu Zhifeng , Zhang Na , Guo Ziquan 
Published: July 2022

Abstract
Purpose
To investigate the filling state of the esophagus using different oral contrast agents for the diagnosis of esophageal cancer by computed tomography (CT).

Materials and methods
This preliminary clinical trial enrolled patients with suspected esophageal carcinoma and admitted from January 2015 to January 2018. The patients were randomized into the yogurt (mixed with ioversol), lotus root powder (mixed with ioversol), gas-producing powder, and control (pure iodine water) groups. Chest CT examinations were performed. The degree of esophageal filling and the detection of esophageal lesions were compared.

Results
Finally, 136 participants were enrolled (n = 34/group). There were no significant differences in esophageal filling degree among the yogurt, lotus root powder, and gas-producing powder groups (P = 0.093). There were 30/3/1 and 30/3/1 confirmed/false-negative/false-positive diagnoses in the yogurt and lotus powder groups, respectively, compared with 28/5/1 and 25/8/1 in the gas-producing powder and control groups, respectively. The concordance rates were the highest for the yogurt (88.2%, with 91.7% specificity and 86.4% sensitivity) and lotus root powder groups (88.2%, with 92.3% specificity and 85.7% sensitivity) and the lowest for the control group (73.5%, with 90.0% specificity and 66.7% sensitivity).

Conclusion
Yogurt mixed with ioversol could fill and expand the esophagus with minimal preparation, displaying the structure of the esophageal lumen and wall thickness. This mixture might be used as a positive contrast agent for esophageal CT. Similar results were observed for the lotus root powder mixed with ioversol, but its preparation was more arduous.
Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
Authors: Sanuki Naoko , Takeda Atsuya , Tsurugai Yuichiro , Eriguchi Takahisa 
Published: July 2022

AbstractIn the treatment of colorectal cancer patients with distant metastases, the development of new anticancer agents has considerably prolonged progression-free survival. Such survival benefits attributed to chemotherapy have increased the relative significance of local therapy in patients with limited metastases. The liver is recognized as the most common site of metastasis of colorectal cancer because of the intestinal mesenteric drainage to the portal veins. Hepatic resection of isolated liver metastases of colorectal cancer is the only option for a potential cure. However, hepatic metastases are resectable in only approximately 20% of the patients. For remaining patients with high-risk resectable liver metastases or those who are unfit for surgery, less invasive, local therapies including radiation therapy (stereotactic body radiation therapy, SBRT) may have a potential role in treatment. Although the local control rate of SBRT for colorectal liver metastases has room for improvement, its less-invasive nature and broad indications deserve consideration. Future research should include SBRT dose escalation or the selection of patients who benefit from local ablative therapies. SBRT may offer an alternative, non-invasive approach for the treatment of colorectal liver metastases in a multidisciplinary treatment strategy.
Is there any health danger by radioactivity on the use of dimensional stones?
Authors: Siegesmund Siegfried , Pereira Alcides , Sousa Luís , Rucker Stine , Kallas Leander , Kopka Bernd , Domingos Filipa , Seco Sérgio 
Published: July 2022

AbstractNatural building stones must be analysed according to a legally defined procedure to prove that the natural radioactivity they emit is below the so-called activity index given by European Commission. This applies in particular to rooms inside buildings or apartments that are used by people for longer periods of time. Gamma spectrometric measurements were determined for all nuclides involved, 40K, 226Ra and 232Th, which were finally summed up to a total dose for each sample. Measurements are prescribed to check whether the reference value of 1 milli-Sievert per year can be exceeded by radionuclides in the respective building materials. Natural stones, 82 in total from all over the world, such as various igneous, metamorphic and sedimentary rocks, which are currently used as building stones for interior and exterior finishing, as kitchen worktops, floor tiles, wall cladding, table tops, furniture cover plates, paving stones, terrace slabs, paving slabs, stairs, street furniture, etc., were selected. Additionally, Rn-222 and Rn-220 exhaled per unit mass were determined simultaneously on 54 selcted from the total 82 rocks by using the accumulation method. In addition, our results were statistically compared with literature data, according to which fesic igneous rocks, gneisses and clay mineral-rich rocks have the highest potential to be radiologically threatening. Limestones, marbles, quartzites, mafic igneous rocks and sandstones are generally less radiologically harmful, but even here there are exceptions depending on the geological formation history and mineralogical composition. The highest activity index of 1.87 was determined for the gneiss Giallo California. Model calculations to determine the expected radiation exposure for a human were used by applying two less complex approaches. Even with the extreme model “coffin”, which consists of the Gialo California, a human experiences only a maximum dose rate of 1.29 mSva−1, which is far below the maximum dose rate of 20 mSv a−1 allowed for occupational radiation exposure. The 220Rn and 222Rn are often neglected; however, their contribution to the dose rate received by the population may be significant. Model simulations for a room with 4 m × 3 m × 2.5 m where the walls and the floor coverd with tiles of 1 cm thickness show a maximum indoor radon concentration of less then 100 Bg m−3. With increase in thickness of the tiles up to 3 cm, 10 cm and 20 cm and for poorly ventilated rooms especially some granitoids, gneisses and the copper-rich shale are above the allowed limit of the European Commission.
Academic integrity in upper year nursing students’ work-integrated settings
Authors: Miron Jennie , Wilson Rosemary , Freeman John , Sears Kim 
Published: July 2022

AbstractWork-integrated learning (WIL) is an educational approach that aims to support students’ integration of theory to practice. These rich learning opportunities provide students with real-world experiences and introduce practice and ethical situations that help consolidate and bridge their knowledge and skill. Academic integrity has been defined as the ongoing commitment to values that are consistent with ethical practice: honesty, trust, fairness, respect, responsibility, and courage (International Centre for Academic Integrity, 2021). It is important to understand what specifically influences students’ intentions to behave with integrity in WIL settings. This paper reports on one study that explored predictors to students’ intentions to behave with integrity across three different WIL settings in their upper years of studies. The findings and recommendations from the research may help to inform other professional programs that include WIL through their educational offerings.
Leveraging the ExpandNet framework and operational partnerships to scale-up brief Cognitive Behavioral Therapy in VA primary care clinics
Authors: Boykin Derrecka M. , Wray Laura O. , Funderburk Jennifer S. , Holliday Steve , Kunik Mark E. , Kauth Michael R. , Fletcher Terri L. , Mignogna Joseph , Roberson Richard B. , Cully Jeffrey A. 
Published: July 2022

Abstract
Evidence-based psychotherapies (EBPs) are underused in health care settings. Aligning implementation of EBPs with the needs of health care leaders (i.e., operational stakeholders) can potentially accelerate their uptake into routine practice. Operational stakeholders (such as hospital leaders, clinical directors, and national program officers) can influence development and oversight of clinical programs as well as policy directives at local, regional, and national levels. Thus, engaging these stakeholders during the implementation and dissemination of EBPs is critical when targeting wider use in health care settings. This article describes how research–operations partnerships were leveraged to increase implementation of an empirically supported psychotherapy – brief Cognitive Behavioral Therapy (brief CBT) – in Veterans Health Administration (VA) primary care settings. The partnered implementation and dissemination efforts were informed by the empirically derived World Health Organization’s ExpandNet framework. A steering committee was formed and included several VA operational stakeholders who helped align the brief CBT program with the implementation needs of VA primary care settings. During the first 18 months of the project, partnerships facilitated rapid implementation of brief CBT at eight VA facilities, including training of 12 providers who saw 120 patients, in addition to expanded program elements to better support sustainability (e.g., train-the-trainer procedures).
THE SOUNDSCAPE OF THE HUAINANZI 淮南子: POETRY, PERFORMANCE, PHILOSOPHY, AND PRAXIS IN EARLY CHINA
Authors: Wong Peter Tsung Kei 
Published: July 2022

AbstractThis article proposes that oral performance could be a philosophical activity in early China. The focus is on the Huainanzi, a densely rhymed philosophical treatise compiled by Liu An in the second century b.c.e. I show that the tome contains various sound-correlated poetic forms that are intended not only to enable textual performance but also, by means of aural mimesis, to encourage the intuitive understanding of its philosophical messages. Thus scholars of ancient poetry, philosophy, or intellectual history, despite being habituated to reading silently and observing disciplinary boundaries, should be attentive to these sonic patterns in order to do justice to the poetic-cum-philosophical richness and originality of this text. More importantly, I argue that these poetic forms enable readers and audiences to experience, embody, and, above all, enact the Way through textual performance. Thanks to the sound patterns of the Huainanzi, the somatic processes of aural reading and philosophical praxis can occur simultaneously. Vocalization becomes an actionable and repeatable spiritual exercise, which facilitates the intuitive understanding and internalization of philosophical values. In other words, the perennial knowing–doing gap is heroically closed by the Huainanzi.
EXTENSIONAL REALIZABILITY AND CHOICE FOR DEPENDENT TYPES IN INTUITIONISTIC SET THEORY
Authors: FRITTAION EMANUELE 
Published: July 2022

AbstractIn [17], we introduced an extensional variant of generic realizability [22], where realizers act extensionally on realizers, and showed that this form of realizability provides inner models of
$\mathsf {CZF}$
(constructive Zermelo–Fraenkel set theory) and
$\mathsf {IZF}$
(intuitionistic Zermelo–Fraenkel set theory), that further validate
$\mathsf {AC}_{\mathsf {FT}}$
(the axiom of choice in all finite types). In this paper, we show that extensional generic realizability validates several choice principles for dependent types, all exceeding
$\mathsf {AC}_{\mathsf {FT}}$
. We then show that adding such choice principles does not change the arithmetic part of either
$\mathsf {CZF}$
or
$\mathsf {IZF}$
.