bluuebunny/crossref_metadata_2025_split huggingface dataset:
Striatal Hand Deformities in Parkinson's Disease: Hand Surgical Perspectives
Authors: Brogren Elisabeth , Dahlin Lars B. , Franzen Erika , Lindholm Beata 
Published: August 2022

ABSTRACTBackgroundThe knowledge about striatal hand deformities (SHD) in Parkinson's disease (PD), has recently increased but need more attention due to their early impact on dexterity. The focus of clinical studies has been on the staging of SHD severity and neurological features. However, a hand surgical perspective has not been considered.ObjectivesOur purpose was to examine SHD in patients with PD using hand surgical assessment methods and the recommended staging of SHD.MethodsIn this observational study, a specialist in neurological physiotherapy examined 100 consecutive PD patients and identified 35 with suspected SHD, who were then examined by two hand surgeons. Their hands were clinically evaluated for severity of SHD, according to a previous proposed staging, focusing on metacarpophalangeal (MCP) joint flexion, presence of intrinsic and extrinsic tightness, as well as other hand deformities.ResultsThree kinds of deformities were identified among 35 included patients: surgical diagnoses unrelated to PD (n = 5), SHD (n = 23), and PD related hand deformities with increased extrinsic tightness (n = 10); three of these 10 patients had also contralateral SHD, thus are included in SHD group. In addition to previously described MCP joint flexion, swan neck deformity and z‐thumb deformity, we found in most hands finger “clefting,” abduction of the little finger and/or an increased intrinsic tightness, indicating pathology of intrinsic muscles of the hand involved in SHD.ConclusionsSHD diagnosed with a modified staging method, including features of intrinsic and extrinsic hand deformities, should be considered in PD to implement early and more accurate treatment.
Apolipoprotein A4 Restricts Diet‐Induced Hepatic Steatosis via SREBF1‐Mediated Lipogenesis and Enhances IRS‐PI3K‐Akt Signaling
Authors: Cheng Cheng , Liu Xiao‐Huan , He Jing , Gao Jing , Zhou Jin‐Ting , Fan Jing‐Na , Jin Xi , Zhang Jianbo , Chang Liao , Xiong Zijun , Yu Jun , Li Shengbin , Li Xiaoming 
Published: August 2022

ScopeHepatic steatosis and insulin resistance (IR) are risk factors for many metabolic syndromes such as NAFLD and T2DM. ApoA4 improves glucose hemostasis by increasing glucose‐stimulated insulin secretion and glucose uptake via PI3K‐Akt activation in adipocytes. However, whether ApoA4 has an effect on hepatic steatosis or IR remains unclear.Methods and resultsApoA4‐knockout (KO) aggravates diet‐induced obesity, hepatic steatosis, and IR in mice promoted by increased hepatic lipogenesis gene expression based on RNA‐seq data. Conversely, liver‐specific overexpression of ApoA4 via AAV‐ApoA4 transduction reverses the effect in ApoA4‐KO mice, accompanied by suppressed hepatic lipogenesis, increased lipolysis, and fatty acid oxidation. Short‐term treatment with recombinant ApoA4 protein improves glucose clearance and liver insulin sensitivity, and reduces hepatic lipogenesis gene expression in the absence of insulin. Moreover, in primary hepatocytes and a hepatic cell line, ApoA4 improves hepatic glucose uptake via IRS‐PI3K‐Akt signaling and decreases fat deposition and hepatic lipogenesis gene expression by inhibiting SREBF1 activity.ConclusionApoA4 restricts hepatic steatosis by inhibiting SREBF1‐mediated lipogenesis and improves insulin sensitivity and glucose uptake via IRS‐PI3K‐Akt signaling in the liver. These findings indicate that ApoA4 may serve as a therapeutic target for obesity‐associated NAFLD.
Influence of carbon nanotube on interfacial and mechanical behavior of carbon fiber reinforced epoxy laminated composites
Authors: Jain Vaibhav , Jaiswal Satish , Dasgupta Kinshuk , Lahiri Debrupa 
Published: August 2022

AbstractReinforcing carbon fiber epoxy composite (CF‐EP) with carbon‐based nano‐fillers offers outstanding mechanical and interfacial properties by strengthening the weak fiber‐matrix interface (delamination) and enhancing the fiber pull‐out strength of neat CF‐EP. In this study, a multiscale CF‐EP laminated composite with CNT modified epoxy matrix has been fabricated by a vacuum‐assisted resin infusion method. Dispersion of 0.3 wt% CNTs into the epoxy are carried out using a probe sonicator. The outcomes indicate that the incorporation of 0.3 wt% CNTs in CF‐EP can improve the ultimate tensile strength (UTS) and interlaminar shears strength (ILSS) by 17% and 28%, respectively. Modulus gradient evaluation across the interface revealed the improvement in the stability of the interface with nanofiller addition. Further, energy absorption during delamination is also improved by 26.31% more due to better interfacial bonding offered by nanofillers.
Ground warming and permafrost degradation in various terrestrial ecosystems in northcentral Mongolia
Authors: Wang Qinxue , Okadera Tomohiro , Watanabe Masataka , Wu Tonghua , Ochirbat Batkhishig 
Published: August 2022

AbstractTo detect the response of permafrost to climate change in various terrestrial ecosystems, we established a permafrost monitoring network in 2007, which includes eight boreholes to monitor ground temperatures in forest, meadow, steppe, moderately dry steppe, and wetland ecosystems and three Automatic Weather Stations (AWS) to monitor climatic factors, such as wind speed (Ws), air temperature (Ta), relative humidity (RH), precipitation (P), solar radiation (Rs), net radiation (Rn), soil heat flux (SHF), soil temperature (Ts), and soil water content (SWC), in forest, meadow, and steppe ecosystems in north‐central Mongolia. Major indicators, including mean annual ground temperature (MAGT), active layer thickness (ALT), and depth of zero annual amplitude (DZAA), were estimated to detect permafrost degradation. The results show that MAGT has increased by 0.00–0.02°C per year (almost no change) in the ice‐poor permafrost areas and by 0.03–0.06°C per year in the ice‐rich permafrost on pingos and wetlands. ALT showed an annual increase of −0.78 to 0.36 cm (almost no change) in the forest and meadow ecosystems and 2.3–7.2 cm in wetland ecosystems, whereas it increased by 23.0–28.9 cm per year in the steppe ecosystems over the last decade. This implies that the permafrost has degraded more rapidly in the steppe ecosystems than in other ecosystems. Based on correlation analysis, ALT is correlated to P in the meadow ecosystems and to SWC in the forest ecosystem, and MAGT is correlated to RH. However, both ALT and MAGT show a close correlation with major climatic factors, such as Ta, RH, SHF, and SWC in the steppe ecosystem. DZAA shows a close negative correlation with Ta in all ecosystems. These results provide evidence for permafrost degradation and its different responses to climate change in various terrestrial ecosystems.
Distributed cohesive configuration controller for a swarm with low‐cost platforms
Authors: Lee Seoung Kyou 
Published: August 2022

AbstractThis study presents acohesive configuration controllerfor distributed space coverage by a swarm of robots. The goal is to build a dense, convex network that is robust against disconnection while robots are flocking with only incomplete knowledge about the network. The controller is an integrated framework of two different algorithms. First, we present aboundary forcealgorithm: physics‐based swarm intelligence that borrows the concept of surface tension force between liquid molecules. The combination of such a force with conventional flocking produces a convex and dense configuration without knowledge of the complete geometry of a robot network. Second, robots distributively determine when a configuration is on the verge of disconnection by identifying a local articulation point—a region where the removal of a single robot will change the local topology. When such a point is detected, robots switch their behavior toclustering, which aggregates them around the vulnerable region to remove every articulation point and retain a connected configuration. Finally, we introduced an index that objectively represents the level of risk of a robot configuration against the massive fragmentation, calledvulnerability index. We provide theoretical performance analyses of each algorithm and validate the results with simulations and experiments using a set of low‐cost robots.
Metal‐and Base‐Free Oxidative Cleavage of C(O)−C Bond in Ketones to Access Esters
Authors: Zhou Zhengrui , Pi Shaofeng , Wang Ru 
Published: August 2022

AbstractA novel strategy to selective cleavage and esterification of C(CO)−C bonds is described. The efficient approach showed a prominent merit compared to previously reported systems, without high temperature, high pressure, inert gas protection, and transition‐metal free. Meanwhile, a rational C−C bond cleavage possible mechanism is proposed by the control experiments.
Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano[2,3]pyrazole Derivatives
Authors: Moeinimehr Mahtab , Safaiee Maliheh , Zolfigol Mohammad Ali , Taherpour Avat Arman 
Published: August 2022

AbstractIn this study, we presented a description of designing and synthesizing an original nano‐N‐sulfonated (‐SO3H) phthalocyanine molten salt (vanadium‐oxo pyridiniumporphyrazinato sulfonic acid) [VO(TPPASO3H)]Cl as a recyclable and efficient heterogeneous catalyst with thermal stability for synthesizing pyrazole and dihydropyrano[2,3]pyrazole derivatives. After recycling and reapplying five times, this catalyst indicated no significant decrease in the catalytic activity.
K2S2O8 Mediated Three‐component Radical Cascade C3 Alkylation of Quinoxalin‐2(1H)‐ones with Vinylarenes and 4‐Hydroxycoumarins/4‐Hydroxy‐6‐methyl‐2‐pyrone
Authors: Sharma Suraj , Bhuyan Mayurakhi , Baishya Gakul 
Published: August 2022

AbstractQuinoxalin‐2(1H)‐ones undergo a three‐component radical cascade C3 alkylation reaction with 4‐hydroxycoumarins/4‐hydroxy‐6‐methyl‐2‐pyrone by using vinyl arenes as intermediary radical acceptors. K2S2O8 in dimethylsulfoxide (DMSO) works as the best reagent‐solvent combination, which promotes the reaction under metal‐, photocatalyst‐ and light‐free conditions producing the three‐component products in moderate yields. We also prove the involvement of radicals in the course of the reaction by performing several radical scavenging experiments with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO), diphenyl ethylene, and butylated hydroxytoluene (BHT).
Folate‐Receptor‐Mediated Uptake of Carbon Dots as a pH‐Responsive Carrier for Chemotherapy
Authors: Dubey Naveneet , Ramteke Suman , Jain N. K. , Dutta Tanoy , Lal Koner Apurba 
Published: August 2022

AbstractIn this work, we have synthesized Carbon Dots (CDs) through a single‐step microwave‐assisted method. The synthesized colloidal CDs have narrow size distribution and show excellent optical properties as well as biocompatibility. Folic acid was selected as a carbon precursor to introduce intrinsic folate receptor targeting capabilities of CDs and to achieve high water dispersibility. CDs were characterized by a series of spectroscopic and microscopic techniques followed by anticancer drug Doxorubicin (Dox) conjugation for potential drug release applications. In near‐physiological conditions, the drug loading and the release of Dox were investigated in detail. CDs‐Dox conjugates are sensitive toward pH and showed efficient drug release as monitored kinetically by fluorescence. Further, live‐cell fluorescence imaging using confocal microscopy establishes the pH‐responsiveness of the drug release mechanism and cellular uptake mediated by folate receptors. We believe that such biocompatible nanocomposite will be beneficial in cancer treatment.
Synthesis of 1,2,3‐Triazole Tethered Indole Derivatives: Evaluation of Anticancer Activity and Molecular Docking Studies
Authors: Veeranna Dharmasothu , Ramdas Lakavath , Ravi Guguloth , Bujji Sushmitha , Thumma Vishnu , Ramchander Jadav 
Published: August 2022

AbstractCancer is a major death‐causing disease all over the world for the past few decades. A novel series of 1,2,3‐triazole tethered indole (7a‐l) derivatives have been synthesized and their structures were confirmed by1HNMR,13CNMR, and mass spectral data. All these compounds (7a –l) were screened for anticancer activity against two human cancer cell lines such as MCF‐7 and HepG‐2 cells by MTT assay. Compounds substituted with4‐hydroxy, 4‐methoxy, 2‐methyl, and3‐acetylgroups exhibited more potent activity against MCF‐7 and HepG‐2 cell lines with best IC50values than standard reference Doxorubicin. Molecular docking studies performed on crystal structures of Aurora kinase‐1 and DNA topoisomerase‐2 alpha showed remarkable binding affinity values and key interactions as compared to the standard reference Doxorubicin.
Seeking ways of knowledge synthesis
Authors: Nakamori Yoshiteru 
Published: August 2022

AbstractThis paper begins with the story that systems science, born of modern Western civilization, began to pay attention to traditional Eastern wisdom to deal with management issues. The consequence of the story is that we should complementarily utilize quantitative and rational analysis results and qualitative and intuitive empirical knowledge to solve problems. As a methodology for implementing knowledge synthesis, this paper presents the knowledge construction systems methodology that promotes knowledge management enhanced by systems thinking. Based on this methodology, it introduces the concept of knowledge synthesis enablers, which are conditions or activities that facilitate knowledge synthesis when promoting research and businesses. This paper shows some results of covariance structure analysis using the evaluation data of applied systems research projects and examines the validity of the assumed enabler candidates.
Development of Fishing Vessel Identification Model Based on Deep Neural Network
Authors: Lin Ching‐Hai , Lin Chun‐Cheng , Chen Ren‐Hao , Yeh Cheng‐Yu , Hwang Shaw‐Hwa 
Published: August 2022

This paper presents a deep neural network (DNN)‐based model to recognize fishing vessels. In Taiwan, the vast majority of small fishing vessels are not equipped with an automatic identification system (AIS). As a consequence, the staff in a fishing port administration become heavily loaded when monitoring and managing the fishing vessels accessing a port. The workload is expected to be eased using this work. For the first time in the literature, a captured fishing vessel image was converted to a 128‐dimensional embedding for recognition purposes. The presented model gave a false positive rate (FPR) as low as 1.13% and an accuracy up to 99.47% at threshold = 0.772379. Finally, all the performance metrics, namely, the true positive rate (TPR), the FPR, precision and accuracy, are actually functions of the threshold which can be specified by users to meet specific requirements. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
The Specific Heat of Astro-materials: Review of Theoretical Concepts, Materials, and Techniques
Authors: Biele Jens , Grott Matthias , Zolensky Michael E. , Benisek Artur , Dachs Edgar 
Published: August 2022

AbstractWe provide detailed background, theoretical and practical, on the specific heat of minerals and mixtures thereof, ‘astro-materials,’ as well as background information on common minerals and other relevant solid substances found on the surfaces of solar system bodies. Furthermore, we demonstrate how to use specific heat and composition data for lunar samples and meteorites as well as a new database of endmember mineral heat capacities (the result of an extensive literature review) to construct reference models for the isobaric specific heat cP as a function of temperature for common solar system materials. Using a (generally linear) mixing model for the specific heat of minerals allows extrapolation of the available data to very low and very high temperatures, such that models cover the temperature range between 10 K and 1000 K at least (and pressures from zero up to several kbars). We describe a procedure to estimate cP(T) for virtually any solid solar system material with a known mineral composition, e.g., model specific heat as a function of temperature for a number of typical meteorite classes with known mineralogical compositions. We present, as examples, the cP(T) curves of a number of well-described laboratory regolith analogs, as well as for planetary ices and ‘tholins’ in the outer solar system. Part II will review and present the heat capacity database for minerals and compounds and part III is going to cover applications, standard reference compositions, cP(T) curves, and a comparison with new and literature experimental data.
Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging
Authors: Mostafa Dalia Kamal , Nayel Omnia A. , Abdulmalek Shaymaa , Abdelbary Ahmed A. , Ismail Cherine A. 
Published: August 2022

AbstractLong-term sun exposure is the commonest cause of photoaging, where mutual interplay between autophagy, oxidative stress, and apoptosis is incriminated. In combating photoaging, pharmacological approaches targeted to modulate autophagy are currently gaining more ground. This study aimed to examine repurposing metformin use in such context with or without the antioxidant coenzyme Q10 (coQ10) in ultraviolet A (UVA) irradiation-induced skin damage. The study was conducted on 70 female CD1 mice that were randomly assigned into seven groups (10/group): normal control, vehicle-treated-UVA-exposed mice, three metformin UVA-exposed groups (Topical 1 and 10%, and oral 300 mg/kg), topical coQ10 (1%)-treated mice, and combined oral metformin with topical coQ10-treated UVA-exposed mice. After UVA-exposure for 10 weeks (3 times/week), macroscopic signs of photoaging were evaluated. Mice were then euthanized, and the skin was harvested for biochemical estimation of markers for oxidative stress, inflammation, matrix breakdown, and lysosomal function. Histopathological signs of photoaging were also evaluated with immunohistochemical detection of associated changes in autophagic and apoptotic markers. Metformin, mainly by topical application, improved clinical and histologic signs of photoaging. This was associated with suppression of the elevated oxidative stress, IL-6, matrix metalloproteinase 1, and caspase, with induction of cathepsin D and subsequent change in anti-LC3 and P62 staining in skin tissue. In addition to metformin antioxidant, anti-inflammatory, and antiapoptotic activities, its anti-photoaging effect is mainly attributed to enhancing autophagic flux by inducing cathepsin D. Its protective effect is boosted by coQ10, which supports their potential use in photoaging.
Deviatoric behaviour of compacted unsaturated soils within ($${\varvec{q}},\boldsymbol{ }{{\varvec{v}}}_{\mathbf{w}},\boldsymbol{ }{\varvec{p}}$$) space—an experimental study
Authors: Abeyrathne Arunodi , Jayasundara Chathurika , Costa Susanga , Kodikara Jayantha 
Published: August 2022

AbstractThe coexistence of air and water as a mixture in void spaces in unsaturated soils, makes its mechanical behaviour relatively complex and difficult to be addressed by classical saturated soil mechanics principles. In addition, many engineering problems encountered in practical situations had some part to deal with unsaturated soils and therefore the clear understanding of various behavioural patterns of unsaturated soils is crucial. To date, a large number of attempts are reported in evaluating the mechanical behaviour of unsaturated soils in different stress spaces. The present study evaluates the deviatoric behaviour of compacted unsaturated soils in deviator stress–specific water volume–mean net stress ($$q, {v}_{\mathrm{w}}, p$$q,vw,p) space. The effect of moisture content, confinement and the stress history on the behaviour of compacted unsaturated kaolin subjected to triaxial compression was assessed and the results showed that there exists a critical state surface for compacted unsaturated soils in$$q- {v}_{\mathrm{w}}- p$$q-vw-pspace.
The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT
Authors: Rimini Margherita , Franco Pierfrancesco , Bertolini Federica , Berardino De Bari , giulia Zampino Maria , Stefano Vegge , Andrikou Kalliopi , Arcadipane Francesca , Napolitano Martina , Buno Lavajo Vieira , Alessandra Gerardi Marianna , Olivero Francesco , Ferreri Filippo , Ricardi Umberto , Cascinu Stefano , Casadei-Gardini Andrea 
Published: August 2022

Abstract
Background and Aim
Anal squamous cell carcinoma (SCC) and oropharyngeal cancer (OPC) are rare tumors associated with HPV infection. Bioumoral predictors of response to chemoradiation (CT-RT) are lacking in these settings. With the aim to find new biomarkers, we investigated the role of eosinophils in both HPV-positive anal SCC and HPV-related oropharyngeal cancer (OPC).

Methods
We retrieved clinical and laboratory data of patients with HPV-positive anal SCC treated with CT-RT in 5 institutions, and patients with locally advanced OPC SCC treated with CT-RT in 2 institutions. We examined the association between baseline eosinophil count (the best cutoff has been evaluated by ROC curve analysis: 100 × 10^9/L) and disease-free survival (DFS). Unadjusted and adjusted hazard ratios by baseline characteristics were calculated using the Cox proportional hazards model.

Results
Three hundred four patients with HPV-positive anal SCCs and 168 patients with OPCs (122 HPV-positive, 46 HPV-negative diseases) were analyzed. In anal SCC, low eosinophil count (< 100 × 10^9/L) correlates to a better DFS (HR = 0.59; p = 0.0392); likewise, in HPV-positive OPC, low eosinophil count correlates to a better DFS (HR = 0.50; p = 0.0428). In HPV-negative OPC, low eosinophil count confers worse DFS compared to high eosinophil count (HR = 3.53; p = 0.0098). After adjustment for age and sex, eosinophils were confirmed to be independent prognostic factors for DFS (HR = 4.55; p = 0.0139).

Conclusion
Eosinophil count could be used as a prognostic factor in anal HPV-positive SCC. The worse prognosis showed in HPV-positive patients with high eosinophil count is likely to derive from an unfavorable interaction between the HPV-induced immunomodulation and eosinophils, which may hamper the curative effect of RT.
Validation of the Attitude Scale to Lesbian, Gay, Bisexual and Transgender Old Age in a Colombian Sample
Authors: Sánchez-Fuentes María del Mar , Parra-Barrera Sandra M. , Fernandes de Araújo Ludgleydson , Pereira Monteiro Renan 
Published: August 2022

AbstractThe Attitude Scale to Lesbian, Gay, Bisexual and Transgender Old Age (EAFV-LGBT) evaluates attitudes towards LGBT older adults. The main goal of this research was to adapt and examine the psychometric properties in a Spanish-speaking sample. The sample consisted of 521 Colombian adults (36.3% men and 63.7% women) with a mean age equal to 27.39 (SD = 9.27). Participants completed a Socio-Demographic and Sexual History Questionnaire, the Hispanic translations of the EAFV-LGBT, the Subtle and Manifest Prejudice Scale towards Homosexuals, and the Big Five Personality Trait Short Questionnaire. The results showed that the Colombian EAFV-LGBT has good psychometric properties. The structure of the scale was unidimensional, and the internal consistency reliability was also adequate. Likewise, the convergent validity of the scale was verified by correlating it with another measure that evaluates explicit and implicit homophobia. In addition, it was found that there was a relationship between personality traits and attitudes towards LGBT adults. Specifically, participants with lower openness, extraversion, and agreeableness reported more negative attitudes toward older LGBT people.