bluuebunny/crossref_metadata_2025_split huggingface dataset:
50C fast-charge Li-ion batteries using graphite anode
Authors: Sun Chuangchao , Ji Xiao , Weng Suting , ruhong Li , Huang Xiaoteng , Zhu Chunnan , Xiao Xuezhang , Deng Tao , Chen Lixin , Wang Xuefeng , Wang Chunsheng , Fan Xiulin 
Published: May 2022

Abstract
Li-ion batteries (LIBs) now have made inroads into the electric vehicle market with high energy densities, yet they still suffer from slow kinetics limited by the graphite anode. Here, we design electrolytes enabling extreme fast charging (XFC) of microsized graphite anode without Li plating. The comprehensive characterizations and simulations on the diffusion of Li+ in the bulk electrolyte, charge-transfer process, and the solid electrolyte interphase (SEI) demonstrate that high ionic conductivity, low desolvation energy of Li+ and protective SEI are essential for XFC. Based on the criterion, two fast-charging electrolytes are designed. Low-voltage 1.8 M LiFSI in 1,3-Dioxolane (DOL) ether electrolyte is for LiFePO4||graphite cells, while high-voltage 1.0 M LiPF6 in a mixture of 4-Fluoroethylene Carbonate (FEC) and Acetonitrile (AN) (7:3 by vol.) is for LiNi0.8Co0.1Mn0.1O2||graphite cells. The former electrolyte enables the graphite electrode to achieve 180 mAh g−1 at 50C (1C=370 mAh g-1), which is 10 times higher than that with conventional electrolyte. The latter electrolyte enables LiNi0.8Co0.1Mn0.1O2||graphite cells (2 mAh cm−2, N/P ratio = 1) to provide a record-breaking reversible capacity of 170 mAh g-1 at 4C charge and 0.3C discharge. This work unveils the key mechanisms for XFC and provides instructive electrolyte design principles for practical fast-charging LIBs with graphite anodes.
Marine algae extracts effects on cell proliferation on a malignant melanoma cell line and an immortalized fibroblast cell line
Authors: Ramezanpour Zohreh , Pirbasti Fateme Ghanbari , Waaland J. Robert 
Published: May 2022

Abstract
Methanol extract fractions from three Persian Gulf seaweeds were tested for their effects on cell proliferation in a human malignant melanoma cell line (A375) and immortalized human foreskin fibroblast cell line (Hu02-KP). The seaweeds Gracilaria salicornia, Padina boergesenii, and Polycladia myrica were collected from the intertidal zone of Qeshm Island. Cell survival and proliferation were assessed by ELIZA and MTT assays. Some fractions from G. salicornia and P. boergesenii showed significant inhibition of proliferation in the melanoma cell line (41-58% and more than 85% respectively) but not the fibroblast cell line. The most abundant components identified in both species were 1, 2 –benzenedicarboxylic acid, diisooctyl ester and hexadecanoic acid, methyl ester.
Social determinants and mental health needs of Palestine refugees and UNRWA responses in Gaza during the Covid-19 pandemic: a qualitative assessment
Authors: Jamal Zeina , ElKhatib Zoheir , AlBaik Shatha , Horino Masako , Waleed Mohammed , Fawaz Farah , Loffreda Giulia , Akihiro Seita , Witter Sophie , Diaconu Karin 
Published: May 2022

Abstract
Background: Refugees are particularly vulnerable to the negative consequences of the pandemic due to pre-existing challenges, but the impact of the pandemic on this group remains to be understood. In this study, we aimed to uncover the effects of the Covid-19 pandemic on the mental health of Palestine refugees in Gaza, disentangling the role of social determinants. We further aimed to explore views on the effectiveness and acceptability of policies and strategies the United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) implemented during the pandemic.Methods: This qualitative study took place between August and November 2020. Twenty-nine key-informant interviews were conducted with UNRWA Headquarters, Gaza Field Office, Health and Relief and Social Service staff and with community leaders and members residing in Rafah and Jabalia camps. We collected information on UNRWA’s strategies, people’s perception of those strategies, and personal and professional stressors during the pandemic. Data was coded based on the framework for social determinant of mental health. Results: Interview data suggest that the pandemic and social determinants mutually aggravated one another resulting in a major impact on the physical and mental health of Gazans. Women, children and daily-paid workers were acutely more disadvantaged than other groups of the community, experiencing violence and anxieties. Financial strain, violence, food insecurity, and disruption in the education process were reported by all participants. UNRWA reconfigured its methods of service delivery to continue the provision of essential services. The strategies enacted by UNRWA during the pandemic were generally perceived as helpful, yet not enough to respond to Gazans’ needs.Conclusion: The pandemic serves as a stark reminder of the need to broaden the public health response beyond disease management and prevention to address social determinants in order to improve refugees’ health and decrease their vulnerability to future shocks. UNRWA deployed telemedicine and mental telehealth services at short notice and the need to evaluate these new modes of remote service delivery is essential. The use of a hybrid approach, a combination of online and face-to-face therapy, could be useful as a long-term solution.
Improved hLigI inhibition activity of Curcumin Monocarbonyl Analogue-Dithiocarbamate Hybrids: Design, Synthesis and Biology
Authors: Singh Deependra Kumar , Mandalapu Dhanaraju , Kumar Sushil , Maurya Pooja , Krishna Shagun , Thakur Subhadra , Pant Suyash , Siddiqi Mohammad Imran , Sharma Vishnu Lal , Banerjee Dibyendu 
Published: May 2022

Abstract
Human DNA ligase (hLigI) plays an important role in the process of DNA replication and repair, making it an important target for cancer. In our tireless efforts for finding selective inhibitors against hLigI, this article reports the design, synthesis and biological activity of a series of 71 curcumin-monocarbonyl-dithiocarbamate hybrid molecules. Many of the synthetic compounds tested in this study show a significant inhibitory effect on the human DNA ligase 1 (hLig1) activity (> 90% inhibition) and demonstrated significant anti-proliferative activity against colon cancer cells (DLD-1) in a concentration dependent manner. In addition, at a concentration of 10 µM, certain compounds showed selective activity towards DLD-1 cells as compared to the normal HEK-293 cells. Overall, our studies demonstrate that two compounds in this series (27 and 49) have significantly better DNA ligase 1 inhibition and anti-proliferative activities than the previously reported monocarbonyl-curcumin hybrid (compound 23*). This study brings us closer towards our quest to explore the molecular space for novel hLig1 inhibitors and to find inhibitors that will be suitable for clinical trials in cancer patients.
Association of domain-specific physical activity with depression: findings from NHANES 2007-2018
Authors: Zhang Hui , He Fan , Li Yi , Hu Zixin 
Published: May 2022

Abstract
It remains unclear whether all PA domains (e.g., occupation related [OPA], transportation related [TPA] and leisure-time [LTPA]) have equivalent beneficial effects. We aimed to investigate associations of OPA, TPA and LTPA with depression in adults. We included and analyzed 31221 participants (aged ≥18 years) from cross-sectional survey of 2007-2018 U.S. National Health and Nutrition Examination Survey (NHANES). The PA domains were assessed by self-reported questionnaire and categorized based on the PA Guidelines. Depressive symptoms were measured by the 9-item Patient Health Questionnaire. Participants achieving PA guidelines (≥150 min/week) were 26% (Odd ratio [OR] 0.74, 95% confidence interval [CI] 0.68-0.80) and 43% (OR 0.57, 95% CI 0.51-0.62) less likely to have depression depending on total PA and LTPA, respectively; while OPA or TPA was not demonstrated lower risks of depression. LTPA at levels of 1-149, 150-299 and ≥300 min/week was associated 31% (OR 0.69, 95% CI 0.60-0.78), 43% (OR 0.57, 95% CI 0.49-0.67) and 51% (OR 0.49, 95% CI 0.43-0.55) lower odds of depression, respectively. LTPA, but not OPA or TPA, at any amount, was associated with lower risk of depression, suggesting significant mental health would benefit from increased PA, even at levels below the recommendation.
The behavioral responses of Ceratitis capitata (Diptera: Tephritidae) to hydrolyzed yeast and some sugars
Authors: Tiring Gülsevim , Satar Serdar 
Published: May 2022

Abstract
Ceratitis capitata Wiedemann (Diptera: Tephritidae) is a major pest of fruits and vegetables worldwide. The nine different sugars and yeast were evaluated to determine the behavioral response of adult C. capitata using a four-arm olfactometer. The sugars used in the study are fructose, alpha glucose, galactose, ribose, arabinose, sucrose, trehalose, melibiose, and maltose. The results showed that C. capitata had a significantly higher attraction to ribose, arabinose, fructose, melibiose, and trehalose than the other four sugars tested. The number of C. capitata that responded to trehalose was higher than the other sugars, so we tested the behavioral response of adult C. capitata to hydrolyzed yeast, trehalose, hydrolyzed yeast + treholese, and control. Our study demonstrated that in four-arm olfactometer bioassays, C. capitata was more attracted to treated arms with hydrolyzed yeast + treholese than those treated with hydrolyzed yeast, trehalose, and untreated arm. These findings can provide insights into the development of more effective sugar-based toxic baits and attractants for traps for the operational application in C. capitata control programs.
Prevalence and Economic Burden of Dementia in The Arab World
Authors: Qassem Tareq , Itani Lynn , Al-Ayyat Dania , Javaid Syed Fahad , Al-Sinawi Hamed 
Published: May 2022

Abstract
BackgroundIn 2021 an estimated 55 million people were living with dementia globally, and this number is predicted to increase to 78 million by the end of this decade. As an irreversible, progressive condition, dementia poses a serious economic challenge to health systems worldwide. There is also an indirect economic burden on the informal carers and families looking after individuals living with dementia. Due to the scarcity of updated estimates about the cost of dementia in the Arab world, this article aims to calculate this economic burden for the year 2020. MethodsUsing the data relevant to the Arab countries, we estimated the number of individuals above 50 living with dementia in Arab countries. We calculated the direct cost of dementia, considering the cost per individual with dementia for the resources used to treat dementia related to the Gross Domestic Product per capita. We also calculated the indirect cost of dementia, defined as the cost of using the caregiver’s time. ResultsThe total direct cost of dementia in the region was estimated at $16,462.5 million for those over 50 and $15,463.8 million for those over 60. In the calculations for indirect cost, we considered the best-case scenario (1.6 hours per day of caregiver support with activities of daily living) and the worst-case scenario (3.7 hours per day). For those above the age of 50, the indirect cost was $2,699.2 million for the best-case scenario and $6,241.9 million for the worst-case scenario. For those above the age of 60, the indirect cost was $2,502.1 million for the best-case scenario and $5,786.0 million for the worst-case scenario. ConclusionsOur findings show that with the demographic changes occurring in the Arab world, dementia will represent a greater challenge, and the burden of the condition is predicted to increase. The results of this study are important for the allocation of resources and the financing of care for both patients and their caregivers. Further studies investigating the efficient use of resources and the cost-effectiveness of interventions in the region are highly recommended.
Comparison the cooking methods of Araujia sericifera on nutritional, physicochemical, antioxidant and sensory properties: multi-criteria decision-making analysis
Authors: Inanir Cansu , Dedebas Tugba , Capar Tugba Dursun , Ekici Lutfiye , Yalcin Hasan 
Published: May 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Outcomes of Vertex-Vertex vs. Vertex-Breech Presentation in Twin Pregnancy after Vaginal Delivery
Authors: Liu Huahua , Yan Shuhan , Wu Fan , Bai Ting , Zhang Feng 
Published: May 2022

Abstract
Background: Vertex-vertex and vertex-nonvertex presentations are the most common and advisable for vaginal delivery. We aimed to explore the maternal and neonatal outcomes of twin pregnancy between vertex and non-vertex presentations of the 2nd twin in vaginal delivery. Methods: In this unicentric retrospective cohort study, data of 213 mothers during twin pregnancy after vaginal delivery from January 2016 to July 2020 were collected. The women were divided into the vertex-vertex presentation group (VV) and vertex-breech presentation group (VB). Data of maternal and neonatal outcomes were compared between groups. Results: Among the 213 mother-infant dyads, there were 140 women in the VV group and 73 women in the VB group (65.73% vs. 34.27%). There were more males for the 1st fetus (60.3% vs. 35.7%, P=0.001), less twin-to-twin delivery interval (12.260±10.437 min vs. 9.360±6.509 min, P=0.032), less birthweight for the 2nd fetus (2218.160±42.698 g vs. 1999.040±66.288 g, P=0.045), greater birthweight discordance (233.814±16.576 g vs. 273.260±31.688 g, P=0.024), earlier gestational age (243.214±1.626 day vs. 235.2055±2.455 day, P=0.030), more breech extraction used (98.6% vs. 0, P<0.001) in the VB group. Infants in the VB group had a higher incidence of admission to NICU (P=0.017), lower 1-minute (P<0.001) and 5-minute Apgar score (P=0.043) for the 2nd twin. After the adjustment of the twin gender, birth weight, chorionic properties and gestational age, the 2nd twin in the VB group still had lower 1-minute Apgar scores. Adjusted linear regression showed that twin presentation remained associated with gestational age (P=0.045).Key Conclusions: The 2nd twins of the vertex-breech presentation have lower 1-minute Apgar scores compared with those in the vertex-vertex presentation. Fetal presentation is an independent factor for 1-minute Apgar score. Fetal presentation is associated with increased odds of preterm. However, further exploration of this relationship is still needed.
Is legal status associated with mental illness among newly arrived refugees in Sweden: an epidemiological study
Authors: Delilovic Sara , Hagström Ana , Shedrawy Jad , Hollander Anna Clara , Lönnroth Knut , Hasson Henna 
Published: May 2022

Abstract
Background: There are about 80 million forcibly displaced people globally. Migrants are at heightened risk for mental illness compared to host country populations. While previous research highlights the need to adequately assess mental illness, few have taken the diversity among newly arrived migrants into account. This study aims to estimate the prevalence and associated risk factors of mental illness among asylum seekers, quota and other refugees in Stockholm, Sweden.Methods: Using a cross-sectional design, data was collected as part of a mental health screening initiative integrated into routine health examinations in two health care clinics in Stockholm. Screening was done with the Refugee Health Screener, RHS-13, a validated instrument for assessing mental health in refugee populations. Results: A total of 1163 individuals were eligible for screening, of whom 566 participated (response rate 48.6 %). Among the participants 47.9% indicated symptoms of mental illness. Compared with asylum seekers, the risk of mental illness was lower among quota and other refugees (adjusted odds ratio 0.60, 95% confidence interval 0.37-1.00). Female gender, higher age, coming from a middle-income country and low probability of being granted asylum were significant predictors of mental illness.Conclusion: Refugee legal status is associated with mental illness. Asylum seekers are at greater risk of mental illness compared to quota and other refugees. Our findings call for screening for mental illness among newly arrived migrants, especially among those with pending residence permits.
2H-Pyrano[3,2-c]chromene-2,5(6H)-diones: Synthesis, characterization, photophysical and redox studies for potential optoelectronic applications
Authors: Kurma Siva Hariprasad , Somanaboina Ramya , Vanammoole Lakshmi Reddy , Srivi K. S. , Bhimapaka China Raju , Giribabu Lingamallu 
Published: May 2022

Abstract
Herein, we report the preparation of 2H-pyrano[3,2-c]chromene-2,5(6H)-diones 3a-x by reacting 4-hydroxycoumarins 1a-b with Baylis-Hillman adducts 2a-w having electron releasing or electron withdrawing groups on benzyl ring of the pyranochromene moiety and study of their photophysical properties. The study of optical and electrochemical properties of the prepared compounds reveals that the electron releasing and electron withdrawing groups has not much impact on ground and excited state electronic behavior on pyranochromene moiety. The density functional theory suggests the highest occupied molecular orbital and lowest unoccupied molecular orbitals spread on coumarin moiety of pyranochromene unit. Further, these compounds are thermally stable (up to 200 oC) and lead to blue or green emission that should facilitate the development of organic light emitting diodes (OLEDs).
The role of environmental heterogeneity on lizard assemblages along Cyprus riverbanks
Authors: Erotokritou Elena , Mammides Christos , N. Ioannis Vogiatzakis , Sfenthourakis Spyros 
Published: May 2022

Abstract
Despite global efforts to halt biodiversity loss, it continues to decline due to a combination of unsustainable actions, increasing the urgency for measures to reverse this trend. A major constraint regarding efficient biodiversity management is the lack of knowledge on most species' population size and abundance patterns. Reptiles are used in ecological research as model organisms due to their ease in handling, and their diversity in behaviour and ecology. Reptile diversity of Cyprus is high and includes several endemic species. The aim of this study was to compare lizard diversity patterns along riverbanks within and around designated protected areas. Riparian habitats have received less attention in conservation-oriented studies in Mediterranean regions, despite their ecological significance and the distinct communities they host, or their vulnerability to climate change. The role of environmental factors, seasonality, and habitat heterogeneity for lizard assemblages in riparian areas was evaluated along three rivers that flow inside and outside protected areas. The abundances of the four more common species (Ophisops elegans, Phoenicolacerta troodica, Laudakia cypriaca, and Acanthodactylus schreiberi) were evaluated separately. We recorded most of Cyprus’ lizard species in riparian habitats, but diversity and richness were not associated with any of the explanatory variables. The abundances of the four species exhibited different relationships each with elevation, season, and protection status, but not with habitat heterogeneity. The latter could be related to the fact that riparian habitat heterogeneity patterns are very similar throughout the study sites. Our results suggest that Cyprus’ lizard diversity and riparian habitats have not been considered much in the design of protected areas.
Electrospun Manuka Honey@PVP nanofibers enclosing Chitosan-Titanate for Highly Effective Wound Healing
Authors: El-Dek S.I. , kassem L.M. , El-Deen Ahmed G. , Zaki A.H 
Published: May 2022

Abstract
Abstract
The major challenge in skin tissue engineering is the creation of physically and functionally suitable extracellular matrix (ECM) scaffolds. Inspired by ECM macromolecular components, we suggest a new hybrid scaffold. Nanocarriers for drug delivery have been successfully created utilizing an electrospinning approach for a manuka honey treated polyvinyl pyrrolidine (Mh@PVP) hybrid composite. Different characterizations tools, including SEM, XRD, TEM, and FTIR. have been utilized to elucidate the fabricated electrospun nanofibrous scaffolds (ENS). The polyvinyl pyrrolidine (PVP) solutions' mechanical, tensile, and conductivity characteristics were greatly enhanced by adding increasing concentrations of Mh to the formula (15%, 20%, 25%). The width and direction of the ENS produced changed as the honey concentration increased. For wound healing, honey's ability to heal wounds faster may be boosted by a higher PVP concentration, which makes honey more easily incorporated. In an XRD investigation, honey and CT-TiONTs had a minor influence on the overall crystallinity of the ENS sample. Because of its burst-and-continuous methylglyoxal release patterns, which may last for up to seven days, manuka honey is an excellent choice for helping the body's healing process. The invivo assessment of the Mh@PVP nanocomposite nanofiber mat demonstrated a rapid and substantial increase in keratinocyte expression, reflecting great ability for high regenerative wound healing. Most significantly, there is no scarring associated with hair regrowth. This scaffold can mimic skin characteristics and stimulate keratinocyte development and act as a growth factor.
Metagenomic analysis reveals unexplored diversity of archaeal virome in the human gut
Authors: Li Ran , Wang Yongming , Hu Han , Tan Yan , Ma Yingfei 
Published: May 2022

Abstract
The human gut microbiome has been extensively explored, while the archaeal viruses remain largely unknown. Here, we conducted a comprehensive analysis to identify human gut archaeal virus sequences in 3,971 assembled metagenomes and the existing human gut virus collections using the CRISPR spacer and viral signature-based approach. This resulted in 1,279 archaeal viral species, of which, 95.2% infected Methanobrevibacteria_A, 85.1% were not found in existing virus collections, 43.5% shared identity < 95% with the proviruses in the UHGG archaeal genomes, 37.2% had a host range spanning > 2 archaeal species, and 55.7% were highly prevalent in > 1% of the human population. Besides viral hallmark genes, the archaeal viral genetic repertoire includes a methanogenic archaeal virus-specific gene peiW that frequently occurred in the viral sequences (n = 150). The analysis of 33 complete caudoviral genomes often discovered the genes (integrase,n = 29; MazE, n = 10) regulating the viral lysogenic-lytic cycle, demonstrating that the temperate viruses likely predominate in the human gut archaeal virome. Together, our work uncovers the considerable unexplored diversity of the human gut archaeal viruses, revealing the novel and unexpected facet of the human gut microbiome.