bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of immune hub genes participating in the pathogenesis and progression of Vogt-Koyanagi-Harada disease
Authors: Wang Yiqi , Ju Yahan , Wang Jiajing , Sun Na , Tang Zhimin , Gao Huiqin , Gu Ping , Ji Jing 
Published: July 2022

BackgroundVogt-Koyanagi-Harada (VKH) disease is an autoimmune inflammatory disorder characterized by bilateral granulomatous uveitis. The objective of this study was to identify immune hub genes involved in the pathogenesis and progression of VKH disease.MethodsHigh throughput sequencing data were downloaded from the Gene Expression Omnibus (GEO) and an immune dataset was downloaded from ImmPort. Immune differentially expressed genes (DEGs) were obtained from their intersection in the GEO and ImmPort datasets. Immune hub genes for VKH disease were selected through differential expression analyses, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Disease Ontology (DO), protein-protein interaction (PPI) network, and clustering analyses. Confidence in the immune hub genes was subsequently validated using box plots and receiver operating characteristic (ROC) curves.ResultsA total of 254 DEGs were screened and after the intersection with ImmPort, 20 genes were obtained as immune DEGs. Functional enrichment analysis indicated that the key genes were mainly involved in several types of immune pathways (such as the lymphocyte mediated and leukocyte mediated immune responses, natural killer cell mediated cytotoxicity, and antigen binding) and immunodeficiency diseases. Following PPI network analysis, the top seven genes in cluster 1 were selected as potential immune hub genes in VKH. After evaluating the accuracy of the hub genes, one gene (GNLY) was excluded because its expression level was statistically similar in VKH patients and healthy controls. Finally, six immune hub genes, namely KLRC2, KLRC3 SH2D1B, GZMB, KIR2DL3, and KIR3DL2 were identified as playing important roles in the occurrence and development of VKH disease.ConclusionSix immune hub genes (KLRC2, KLRC3 SH2D1B, GZMB, KIR2DL3, and KIR3DL2) identified by our bioinformatics analyses may provide new diagnostic and therapeutic targets for VKH disease.
A Cryptogenic Stroke Associated With Infective Endocarditis and Antiphospholipid Antibody Syndrome: Case Report and Literature Review
Authors: Chen Lei , Zhang Ping , Zhu Xuan , Zhang Minmin , Deng Benqiang 
Published: July 2022

IntroductionAccurate definition of stroke etiology is crucial, as this will guide effective targets for treatment. Both antiphospholipid antibody syndrome (APS) and infective endocarditis (IE) can be independent risk factors for ischemic stroke in young adults. When an embolic stroke occurs with IE and APS simultaneously, the origin of the embolic source is difficult to identify.Case ReportA 19-year-old man was admitted to the hospital for the onset of stroke. A diagnosis of APS accompanied by IE was made after a series of examinations. We identified aortic valve vegetation as the embolic source. Although both APS and IE can induce valve vegetation, we considered IE to be the primary cause according to the infective clues. Despite treatment with ampicillin, the patient's fever persisted, and surgical aortic valve replacement was performed urgently. The patient recovered without recurrence of stroke during the 1-year follow-up.ConclusionA considerable challenge for physicians is evaluating all the signs suggestive of embolic sources in acute stroke and identifying the primary etiology when there are multiple causes. Early diagnosis and surgical intervention for bicuspid aortic valve (BAV) vegetation complicated by acute stroke may yield favorable clinical results.
Risk factors for the progression from acute recurrent to chronic pancreatitis among children in China
Authors: Zeng Jingqing , Zhang Jiayu , Hu Yabin , Wang Xiumin , Deng Zhaohui 
Published: July 2022

BackgroundRisk factors for progression from acute recurrent pancreatitis (ARP) to chronic pancreatitis (CP) in children are poorly understood.AimTo summarize the clinical characteristics of children with ARP and CP, identify the risk factors of CP, and investigate the factors associated with rapid progression from initial onset of ARP to CP.MethodsThe following variables were included in the risk factor analysis: sex, age at onset, family history, pancreas or biliary tract structural abnormalities, and genetic variations. Univariate and multivariate logistic regression analyses were used to assess the risk factors of CP. The Kaplan–Meier curves of the ARP progression to CP for various risk factor groupings were constructed and compared using the log-rank test. The Cox proportional hazard regression model was fitted to estimate the hazard ratio (HR) of progression to CP for each risk variable.ResultsIn total, 276 children were studied, of whom 136 progressed to CP. Among them, 41 had pancreatic duct obstructive disease; 105 underwent genetic testing, of whom 68 were found to have genetic variations. Among the remaining 140 patients who did not progress to CP, 61 had biliary obstructions. Forty-three of these children underwent genetic testing, and 15 were found to have genetic variations. Risk factor analysis showed that children with gene mutations were at a higher risk of progressing to CP [odds ratio (OR) = 3.482; 95% confidence interval (CI): 1.444–8.398; P = 0.005]; children with pancreas divisum (PD) had a higher risk of CP than those without (OR = 8.665; 95% CI: 1.884, 9.851; P = 0.006). Further, children whose first ARP occurred at an older age might develop CP faster (HR = 1.070; 95% CI: 1.003, 1.141; P = 0.039). Children with gene mutations had a faster rate of progression to CP after onset than children without gene mutations (HR = 1.607; 95% CI: 1.024, 2.522; P = 0.039), PRSS1 gene mutations were more associated (P = 0.025). There was no difference in the rate of progression from ARP to CP in children with PD (P = 0.887); however, endoscopic retrograde cholangiopancreatography (ERCP) intervention delayed the progression to CP in ARP patients with PD (P = 0.033).ConclusionPRSS1 gene mutations and PD are key risk factors for ARP progression to CP in children. PD itself does not affect the disease progression rate, but therapeutic ERCP can be beneficial to patients with ARP with symptomatic PD and delay the progression to CP.
Figure-Disembedding Is Inferior in Non-autistic Compared to Autistic Individuals but Can Be Improved by Training
Authors: Falter-Wagner Christine M. , Bloch Carola , Robles Marta , Horch Lea , Vogeley Kai , Georgescu Alexandra Livia 
Published: July 2022

BackgroundFigure-disembedding is one of the most discussed visuo-cognitive functions, in which individuals with Autism Spectrum Disorder (ASD) have been reported to outperform non-autistic individuals. A local processing bias has been assumed to underlie such superior performance patterns. The aim of the current study is to investigate whether processing preferences can be modified by procedural priming.MethodThe current study used a procedural priming task (Navon figures) to induce more local or global processing in 25 autistic and 21 typically developing (TD) control participants, using hierarchical figures preceding the figure-disembedding task.ResultsParticipants with ASD outperformed non-autistic individuals in the unprimed baseline task version. The performance was not modulated by priming in either direction (toward a local or global processing style) in both groups. However, the performance of TD control participants was improved by training to the same level as that observed in the ASD group.ConclusionFigure-disembedding performance in ASD is superior to that in TD control participants and robust against procedural priming or training. In contrast, performance in the TD control group can be improved up to the level of the ASD group. Any studies reporting superiority in individuals with ASD in figure-disembedding should consider training effects when evaluating group differences.
Systematic review on somatization in a transcultural context among teenagers and young adults: Focus on the nosography blur
Authors: Salmon Mathilde , Sibeoni Jordan , Harf Aurélie , Moro Marie Rose , Ludot-Grégoire Maude 
Published: July 2022

AimsSomatic complaints are a frequent cause for consultation in primary care. In a transcultural context, somatic complaints are typically associated with psychological distress. A recent review about somatic symptom disorders in adolescence showed some nosographic heterogeneity and outlined various etiological hypotheses (traumatic, environmental, or neurologic), separate from the cross-cultural considerations. Migrants' children encounter specific problems involving cultural mixing-issues of filiation (familial transmission) and affiliation (belonging to a group). This paper aims to provide a systematic review of somatization in transcultural contexts among teenagers and young adults, aged 13 to 24, over the past decade.MethodsThis review adheres to the quality criteria set forth by the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Two authors queried three English databases (Medline, PsycInfo, WebOfScience) about somatization in transcultural contexts (migrant or non-Western population) among teenagers (13–18), young adults (19–24), or both. The methodological process comprised articles selection, data extraction, and then the analysis of emerging themes. Setting selection criteria to limit the transcultural field was difficult.ResultsThe study analyzed 68 articles. We present a descriptive analysis of the results, centered on three main themes. First, the literature highlights a nosographic muddle reflected in the combination of anxious and depressive symptoms together with the highly variable symptomatology. Second, discrimination issues were prevalent among the migrant population. Lastly, the literature review points out possibilities for improving a care pathway and reducing the diagnostic delay induced by migrants' hesitancy about Western care and the recurrent use of inappropriate diagnostic criteria.ConclusionThis review discusses the links between the nosographic muddle described here and the diagnostic delays these patients experience and raises concerns about rigid diagnostic compartmentalization. The work of the psychiatrist Frantz Fanon is here useful to understand externalized symptoms resulting from physical and psychological confinement. Discrimination issues raise questions about the cultural counter-transference health professionals experience in dealing with young migrants. Defining healthcare professionals' representations about somatic complaints in a transcultural context might be a fruitful path to explore in future research.Protocol PROSPERO registration numberCRD42021294132. Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021294132.
Meaning in life as a mediator of dark triad with confidence in treatment and subjective evaluation of treatment outcome among male drug abstainers
Authors: Shi Liping , Sun Shijin , Zhu Xueli , Geng Yaoguo 
Published: July 2022

BackgroundAlthough the roles of personality in predicting substance abuse have been widely documented, few studies have investigated the relationships the dark triad (DT) personalities had with confidence in treatment (CIT) and subjective evaluation of treatment outcome (SETO) in drug abstainers.ObjectiveThis study examined the relationship between DT and treatment-relevant variables, and the potential effect of meaning in life (MIL) in these links.MethodsParticipants were male inpatients who started substance abuse treatment between June and December 2018 in Henan Province, China. The inclusion criteria were the diagnosis of substance use disorders. The exclusion criteria were illiteracy, comorbidity with psychopathology disorders, intellectual disability, and refusal of consent. A total of 236 men (aged 21–62 years, M = 45.30, SD = 7.72) were randomly selected and reported their DT, MIL, CIT, and SETO.ResultsResults showed that DT was negatively correlated with MIL, CIT, and SETO. MIL was positively correlated with CIT and SETO. The dark triad is associated with CIT both directly and indirectly via MIL. DT is indirectly correlated with SETO via MIL. Higher levels of DT in drug abstainers can reduce CIT and SETO by decreasing individual's MIL.ConclusionThis study provides insights into the links between the DT and treatment-relevant variables, which can potentially impact the effectiveness of current substance abuse treatment programs.
Case report: Intranasal esketamine for severe major depressive disorder with psychotic features
Authors: Carter Maximilian , Solsrud Kassandra , Mischel Nicholas 
Published: July 2022

IntroductionAbout one third of patients with major depressive disorder (MDD) have treatment resistant depression (TRD). The difficulty of treating TRD especially in those with suicidal ideation and psychotic features demands treatments that are fast-acting, safe, and effective. Limited access, lack of viable options, and incomplete characterization of rapid-acting antidepressants has prevented widespread incorporation into treatment of patients with TRD. However, ketamine and its variations have shown promise of being effective treatment options for patients with TRD with psychotic features.Case descriptionThis 28-year-old patient with TRD with psychotic features received 14 treatments of intranasal esketamine over a 3-month period. This patient initially presented with anhedonia, difficulty sleeping, suicidal thoughts, and auditory hallucinations. The Quick Inventory of Depressive Symptomology (QIDS) was used to assess depression before each session.ResultsAfter her first two treatment sessions within a week, this patient experienced a reduction in depression from severe to moderate according to the QIDS. Over 14 sessions, she had no significant adverse effects, including no psychotic symptoms during esketamine treatment, and was stabilized to mild depression without suicidal ideations. One year after treatment, she continues to be stable. She has not had auditory hallucinations since the esketamine treatment.ConclusionsThis case report provides an example of a patient with severe TRD with psychotic features that showed significant improvement after treatment with intranasal esketamine. Larger studies are indicated to further elucidate the effectiveness and safety of intranasal esketamine, so it can be more widely used for patients with TRD with psychotic features.
Factors associated with the perception of inadequate sanitary control in 12 Latin American countries during the COVID-19 pandemic
Authors: Mejia Christian R. , Liendo-Venegas Daniela , García-Gamboa Fernanda , Mejía-Rodríguez Miguel A. , Valladares-Garrido Mario J. 
Published: July 2022

IntroductionSanitary control mechanisms differ greatly from country to country. Therefore, it is important to know citizens' perception of different realities. We aimed to determine the factors associated with the perception of inadequate sanitary control in 12 Latin American countries during the COVID-19 pandemic.MethodsThis is an analytical cross-sectional study. We asked about six perceptions in regard to different situations experienced by inhabitants of 12 Latin American countries during the pandemic. Frequencies according to country were described and associations vs. other important variables were obtained.ResultsOut of 8,489 participants, 68% stated that there were moments of collective hysteria. Honduras was the country that most perceived inadequate control mechanisms established by the government. Multivariate analysis showed that there were statistically significant differences among many of the countries according to the six evaluated items. The higher the level of education, the greater the perception of poor control in five of the aspects. Additionally, men had a lower perception of inadequate control. The older the age, the lower the perception of inadequate control regarding whether there was collective hysteria and shortages of basic essentials. Those with COVID-19 had a lower perception of medicine shortages.ConclusionThe population of multiple realities in Latin America have perceived a bad management of the pandemic. Citizens' perception is an important indicator of the performance of each government during the COVID-19 pandemic. This study may provide valuable information on the relationship between the effectiveness of government sanitary control and people's mental health, which ultimately helps to create objective prevention programs against post-traumatic stress disorder, depression, fear of contagion, and collective hysteria. In addition, governments could use this information to design effective mitigation plans for future unavoidable pandemic events based on the six criteria discussed here.
Analisis Valuasi Saham Menggunakan Metode Dividend Discounted Model pada Perusahaan Sub-Sektor Pulp & Kertas
Authors: Anggita Salsabila Dwi , Mai Muhammad Umar , Hadiani Fatmi 
Published: July 2022

Recently, the community has been shocked by a pandemic, namely the Corona Virus (Covid-19) which has an impact on all directions, one of which is the economic sector. The occurrence of global economic uncertainty triggers the Indonesian people to make efforts to maintain their economy. One of them is by investing, especially investing in stocks, especially now that millennials can reach the price of listed share on the IDX. Therefore, the ains of this papper to see the results of the comparison of the intrinsic value of the fair share price with its market price in the pulp & paper sub-sector listed on the IDX in 2016 - 2020 so that it will decide the investment resolve that will be taken by investors whether they are in poor condition. undervalued or overvalued by using the Dividend Discounted Models (DDM) method. The outcome of the analysis in this study obtained that all companies have shares in an overvalued position where the market price is less than the intrinsic value / fair price.
Uso del jengibre (Zinger officinale) y cúrcuma (Curcuma longa) como aditivos fitobioticos en lechones posdestete
Authors: Buenaño-Haro Cristian Xavier , Bravo-Sánchez Luis Ramón 
Published: July 2022

Se realizó la extracción, caracterización y evaluación de aceites esenciales de jengibre (Zingiber officinale) y cúrcuma (Curcuma longa) sobre el rendimiento productivo en lechones de posdestete. Se emplearon 32 lechones del cruce comercial Blanco Belga x Duroc x Pietrain de 10.82 ± 0.77 kg de peso, los cuales se distribuyeron de acuerdo con un diseño completamente aleatorizado en cuatro tratamientos: Control; 0.01; 0.05 y 0.1% de suplementación dietética de una mezcla 50:50 (p/p) de aceite esencial de jengibre y cúrcuma. La suplementación dietética con la mezcla de aceite esencial en los niveles establecidos ocasionó un efecto positivo sobre el consumo, ganancia de peso, conversión alimentaria y peso final de los animales. En conclusión, la suplementación dietética con 0.1% de la mezcla de aceite esencial de jengibre y cúrcuma podría mejorar los índices productivos en lechones posdestete, con superior efecto que los antibióticos y promotores de crecimiento sintéticos.
Percepción de la población sobre la política estatal en relación a los consejos locales de administración de salud (CLAS) de Atuncolla y Chancachi, Puno – Perú
Authors: Neira-Ortega Idaluz , Sánchez-Justo Clodoaldo , Espinoza-Zevallos Carlos 
Published: July 2022

Esta investigación surge frente a la escasa participación de la comunidad en el Consejo Local de Administración de Salud (CLAS) con actividades de carácter operativo (campañas, charlas, etc.) concentradas solo en la administración de los servicios, con escasa preocupación en la calidad de vida, los determinantes de la salud de la población y el cumplimiento de los derechos ciudadanos en salud; para los cuales hay ausencia de canales en la Cogestión y participación ciudadana. La investigación fue de tipo descriptivo con diseño comparativo, la población estuvo conformada por los habitantes de los distritos de Atuncolla y Chancachi, con una muestra de 338 y 291 respectivamente, cuya unidad de análisis estuvo constituida por el jefe de familia mediante la estimación proporción poblacional. La información se obtuvo mediante el cuestionario respecto al conocimiento (establecido en la escala de Likert). Los datos se procesaron a través del análisis estadístico de Chi Cuadrado. Los resultados determinan que el nivel de percepción que tiene la población sobre la política estatal en relación a los CLAS está conformado por un conocimiento deficiente. En el CLAS Chancachi los pobladores no conocen el significado CLAS, los órganos que lo conforman, los integrantes del Consejo Directivo, así como las funciones que cumplen, el responsable que maneja el presupuesto y requisitos para ser elegido representante de la asamblea general. En el CLAS Atuncolla, no conocen que órganos conforman el CLAS, quienes son los responsables del manejo del presupuesto, participantes en la contratación de personal, tiempo de renovación de los miembros de la Asamblea General. La mayoría de los pobladores muestran actitudes indiferentes con tendencia a ser negativa; mientras, en el CLAS Atuncolla la tendencia es, a ser positiva; los que incurrirán negativamente en la Cogestión y participación ciudadana. Ambas poblaciones beneficiarias muestran altas expectativas, sobre la organización y funcionamiento de los CLAS, los que permitirán mejorar y reformular la Política Estatal en Salud.
Pengembangan Media Pembelajaran Matematika Berbasis Android Pada Materi Lingkaran Kelas VIII SMP
Authors: Rohmatullah Indah , Afgani Muhammad Win , Nizar Harisman 
Published: July 2022

Tujuan riset ini adalah untuk menghasilkan media pembelajaran berbasis android pada materi lingkaran yang valid dan praktis. Jenis penelitian ini adalah penelitian pengembangan (development research) dengan model pengembangan ADDIE. Subjek penelitian terdiri dari 17 siswa. Data penelitian ini diperoleh dari angket, wawancara, dan dokumentasi. Penelitian ini menghasilkan : (1) Media pembelajaran yang tergolong valid berdasarkan komentar dan saran validator, (2) Media pembelajaran yang tergolong praktis berdasarkan hasil komentar dan saran siswa pada angket dan wawancara.
Meningkatkan Kemampuan Bepikir Kreatif melalui Penerapan Pendekatan Saintifik Berbantuan VBA Excel
Authors: Sugandi Asep Ikin , Bernard Martin , Linda Linda 
Published: July 2022

Masih rendahnya berpikir kreatif siswa SMP dan masih kurangnya penggunaan media belajar berbasis ICT merupakan masalah dalam penelitian ini . Adapun penelitian memiliki tujuan untuk mengetahui efektivitas pembelajaran saintifik dengan bantuan VBA Excel dalam berpikir kreatif siswa. Metode eksperimen merupak metode yang digunakan dalam penelitian ini dengan desain Non Equivalent Control Group Desain, sampel diambil dari dua kelas di satu SMP yang berada di kota Cimahi. Instrumen yang digunakan berbentuk tes kemampuann berpikir kreatif yang berjumlah 5 soal. Hasil dalam penelitian ini menyimpulkan bahwa pembelajaran saintifik dengan bantuan VBA Excel lebih efektif dari pembelajaran biasa dilihat dari kemampuan berpikir kreatif.
Ukraine — NATO: results of 2021
Authors: Onyshchuk Mykhaylo , Tatarinova Larysa 
Published: July 2022

The article analyzes the publications Ukrainian and foreign media on Ukraine's accession to The North Atlantic Treaty Organization also called the North Atlantic Alliance, the positions of the US, NATO, and Russian Federation leaders relatively to strategic course of Euro-Atlantic integration of our country.
The aspirations of our state and the support of Ukraine by the leaders of the Allied countries cover the content of the publications of some Ukrainian mass media on the activities of the Ukrainian authorities on the issue of Euro-Atlantic orientation. The article shows position of the Russian Federation, its readiness to carry out armed aggression against Ukraine if our country joins NATO.