bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upper Crustal Collapse Reconstructed the Topography and Remodeled the Fault System of the Chuandian Fragment in the Southeastern Edge of the Tibetan Plateau, Evidenced by Anisotropy of Magnetic Susceptibility Data Sets
Authors: Tong Yabo , Yang Zhenyu , Pei Junling , Wang Heng , Wu Zhonghai , Li Jianfeng 
Published: April 2022

AbstractThe steps of the southeastward stepwise‐descending topography of the Chuandian Fragment (CDF) in the southeastern edge of the Tibetan Plateau coincide with N‐S and NE‐SW trending faults that changed from thrusting to normal activity, indicating that since the Middle‐Late Miocene the CDF maintained an E‐W oriented extensional tectonic environment. However, the anisotropy of magnetic susceptibility (AMS) data sets presented herein, from the Cretaceous and Cenozoic sedimentary strata of the southeastern Tibetan Plateau and its edge, show that since ∼28.0 Ma the CDF remained within a stabilized compressional stress field, oriented NEE‐SWW. A comprehensive analysis of the AMS results, topography, fault systems, and geophysical observations indicate that the northward‐advancing eastern Himalaya syntaxis impeded the southeastward‐flowing viscous lower crust and correspondingly decreased its flux, which could have reduced the thickness of the lower crustal channel beneath the CDF. The original low‐gradient topography of the CDF formed by the viscous lower crustal flow could no longer be supported by the thinned lower crustal channel, and thus gravity drove the collapse of the uplifted CDF. This process reconstructed the topography and remodeled the preexisting fault systems of the CDF, resulting in the coexistence of the E‐W oriented extensional tectonic environment and the stabilized NEE‐SWW oriented compressional stress field of the western part of the CDF, since the Middle‐Late Miocene. Thus, the change in the status of the lower crustal channel related to block interactions provided a major geodynamic setting for shaping the topography of the southeastern edge of the Tibetan Plateau.
USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ
Authors: Tang Jianing , Luo Yongwen , Xiao Liang 
Published: April 2022

AbstractAnaplastic thyroid cancer (ATC) is one of the most lethal and aggressive human malignancies, with no effective treatment currently available. The Hippo tumor suppressor pathway is highly conserved in mammals and plays an important role in carcinogenesis. TAZ is one of major key effectors of the Hippo pathway. However, the mechanism supporting abnormal TAZ expression in ATC remains to be characterized. In the present study, we identified USP26, a DUB enzyme in the ubiquitin-specific proteases family, as a bona fide deubiquitylase of TAZ in ATC. USP26 was shown to interact with, deubiquitylate, and stabilize TAZ in a deubiquitylation activity-dependent manner. USP26 depletion significantly decreased ATC cell proliferation, migration, and invasion. The effects induced by USP26 depletion could be rescued by further TAZ overexpression. Depletion of USP26 decreased the TAZ protein level and the expression of TAZ/TEAD target genes in ATC, including CTGF, ANKRD1, and CYR61. In general, our findings establish a previously undocumented catalytic role for USP26 as a deubiquitinating enzyme of TAZ and provides a possible target for the therapy of ATC.
ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking
Authors: Kong Chang , Ni Xuqing , Wang Yixiu , Zhang Anqi , Zhang Yingying , Lin Feihong , Li Shan , Lv Ya , Zhu Jingwen , Yao Xinyu , Dai Qinxue , Mo Yunchang , Wang Junlu 
Published: April 2022

AbstractPrevious studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is an imperative molecule that could regulate inflammation and immune response in numerous illnesses, its function in cardiovascular disease, particularly in SIC, is still elusive. We confirmed that LPS significantly enhanced the expression of ICA69 in wild-type (WT) mice, macrophages, and cardiomyocytes. The knockout of ICA69 in lipopolysaccharide(LPS)-induced mice markedly elevated survival ratio and heart function, while inhibiting cardiac muscle and serum inflammatory cytokines, reactive oxygen (ROS), and ferroptosis biomarkers. Mechanistically, increased expression of ICA69 triggered the production of STING, which further resulted in the production of intracellular lipid peroxidation, eventually triggering ferroptosis and heart injury. Intriguingly, ICA69 deficiency only reversed the ferroptotic marker levels, such as prostaglandin endoperoxide synthase 2 (PTGS2), malonaldehyde (MDA), 4-hydroxynonenal (4HNE), glutathione peroxidase 4 (GPX4), superoxide dismutase (SOD), iron and lipid ROS, but had no effects on the xCT-dependent manner. Additionally, greater ICA69 level was identified in septic patients peripheralblood mononuclear cells (PBMCs) than in normal control groups. Generally, we unveil that ICA69 deficiency can relieve inflammation and ferroptosis in LPS-induced murine hearts and macrophages, making targeting ICA69 in heart a potentially promising treatment method for SIC.
Ibandronate promotes autophagy by inhibiting Rac1–mTOR signaling pathway in vitro and in vivo
Authors: Han Jie , Yang Jian , Wang Qiqi , Yin Xiang , Sun Zewei , Huang Chaoyang , Chen Guoping , Zheng Liangrong , Jiang Dongmei 
Published: April 2022

AbstractWe previously reported that ibandronate (IBAN) could improve endothelial function in spontaneously hypertensive rats. However, the mechanism by which IBAN improves endothelial function is unclear. The IBAN-induced autophagic process in vitro experiments were determined by detection of LC3, Beclin1, and P62 protein levels via western blotting. The autophagy flux was detected by confocal microscopy and transmission electron microscopy. For in vivo experiments, spontaneously hypertensive rats were orally administered with IBAN. Utilizing angiotensin II (Ang II) to stimulate the human umbilical vein endothelial cells (HUVECs) and human pulmonary microvascular endothelial cells (HPMECs) as a model of endothelial cell injury in hypertension, we found that IBAN promoted autophagy and protected cell viability in Ang II-treated-endothelial cells while these effects could be reversed by autophagy inhibitor. In terms of mechanism, IBAN treatment decreased the levels of Rac1 and mammalian target of rapamycin (mTOR) pathway. Activating either Rac1 or mTOR could reverse IBAN-induced autophagy. Furthermore, the in vivo experiments also indicated that IBAN promotes autophagy by downregulating Rac1-mTOR. Taken together, our results firstly revealed that IBAN enhances autophagy via inhibiting Rac1-mTOR signaling pathway, and thus alleviates Ang II-induced injury in endothelial cells.
N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
Authors: Zou Libin , Chen Wenbin , Zhou Xumin , Yang Taowei , Luo Junqi , Long Zining , Wu Jun , Lv Daojun , Mao Xiangming , Cen Shengren 
Published: April 2022

AbstractThe fat mass and obesity-associated protein (FTO) is an N6-Methyladenosine (m6A) demethylase, which has been revealed to play critical roles in tumorigenesis. However, its role in the development and progression of prostate cancer (PCa) remains poorly understood. Here, we aimed to investigate the function and clinical relevance of FTO in PCa. Our results demonstrated that FTO was notably downregulated in PCa tissues compared with the paired normal tissues. In addition, the decreased expression of FTO was correlated with poor prognosis of PCa. Functional experiments showed that depletion of FTO promoted the proliferation and metastasis of PCa both in vitro and in vivo. Conversely, ectopic expression of FTO exhibited the opposite effects. Combined with RNA-sequencing, MeRIP-RT-qPCR, and mRNA stability assays indicated chloride intracellular channel 4(CLIC4) was a functional target of FTO-mediated m6A modification. FTO depletion significantly increased the m6A level of CLIC4 mRNA and then reduced the mRNA stability. In conclusion, our findings suggest that FTO suppresses PCa proliferation and metastasis through reducing the degradation of CLIC4 mRNA in an m6A dependent manner. FTO may be used as a promising novel therapeutic target and prognostic evaluation biomarker for PCa.
DCR for nasolacrimal duct stenosis may be less effective than for complete obstruction
Authors: Shapira Yinon , Macri Carmelo , Usmani Eiman , Davis Garry , Selva Dinesh 
Published: April 2022

AbstractObjectivesTo ascertain the success of endo-DCR in nasolacrimal duct stenosis (NLDS) versus nasolacrimal duct obstruction (NLDO).MethodsConsecutive adult patients with epiphora attending a tertiary lacrimal clinic from February 2012 to February 2021 were reviewed. NLDS was diagnosed by patent lacrimal syringing and combined dacryocystography (NLD stenosis) and dacryoscintigraphy (post-sac delay) findings in all eyes. Cases with evidence of canalicular stenosis or other identifiable causes of epiphora were excluded. The epiphora resolution and improvement rates following endo-DCR were compared between NLDS and complete NLDO cases.ResultsDCRs in 24 NLDS (23 patients, 69.6% females, mean age 61.0 ± 17.07) and 58 NLDO (56 patients, 69.6% females, mean age 61.9 ± 17.4) were included. Resolution of epiphora was achieved in 10 (41.7% [95% CI 0.24–0.61]) of the NLDS cases compared to 40 (69.0% [95% CI 0.56–0.79]) in NLDO (p = 0.021). Improvement of epiphora (i.e., either improvement or resolution) was noted in 17 (70.8% [95% CI 0.51–0.85]) of NLDS and 53 (91.4% [95% CI 0.81–0.96]) of NLDO cases (p = 0.034). Three patients (12.5%) with NLDS had subsequent lacrimal procedures (one DCR revision, two Jones tube) at a median of 14 (range 11–21) months. 71.4% of the NLDS patients responded to a phone questionnaire at a median of 93 months postoperatively. Of these, 46.7% reported resolution or significant improvement, and 33.3% reported slight improvement. 64.3% said they would recommend DCR to others suffering from epiphora.ConclusionEndo-DCR may benefit approximately 70% of patients with NLDS. The success of endo-DCR in complete NLDO may be higher.
The efficacy of transcranial magnetic stimulation (TMS) for negative symptoms in schizophrenia: a systematic review and meta-analysis
Authors: Lorentzen Rasmus , Nguyen Tuan D. , McGirr Alexander , Hieronymus Fredrik , Østergaard Søren D. 
Published: April 2022

AbstractSeveral trials have shown preliminary evidence for the efficacy of transcranial magnetic stimulation (TMS) as a treatment for negative symptoms in schizophrenia. Here, we synthesize this literature in a systematic review and quantitative meta-analysis of double-blind randomized controlled trials of TMS in patients with schizophrenia. Specifically, MEDLINE, EMBASE, Web of Science, and PsycINFO were searched for sham-controlled, randomized trials of TMS among patients with schizophrenia. The effect of TMS vs. sham on negative symptoms in each study was quantified by the standardized mean difference (SMD, Cohen’s d) with 95% confidence intervals (95%CI) and pooled across studies using an inverse variance random effects model. We identified 57 studies with a total of 2633 participants that were included in the meta-analysis. The pooled analysis showed statistically significant superiority of TMS (SMD = 0.41, 95%CI: 0.26; 0.56, p-value < 0.001), corresponding to a number needed to treat of 5. Furthermore, stratified analyses suggested that TMS targeting the left dorsolateral prefrontal cortex and using a stimulation frequency >1 Hz was most efficacious. There was, however, substantial heterogeneity and high risk of bias among the included studies. In conclusion, TMS appears to be an efficacious treatment option for patients with schizophrenia suffering from negative symptoms, but the optimal TMS parameters are yet to be established.
Dental tissue remineralization by bioactive calcium phosphate nanoparticles formulations
Authors: Ionescu Andrei Cristian , Degli Esposti Lorenzo , Iafisco Michele , Brambilla Eugenio 
Published: April 2022

AbstractRecent health care products are based on formulations claimed to provide enamel remineralization and dentinal tubules occlusion through calcium-phosphate bioactive nanocompounds (ion-doped hydroxyapatite and precursor, amorphous calcium phosphate nanoparticles). This study aimed to characterize, test, and compare for the first time the structure and performance of a representative, market-available sample of remineralizing toothpastes and topical mousses. Formulations were characterized to determine their composition and investigate the presence of bioactive compounds and doping elements. A conventional fluoride-containing toothpaste was used as reference. The enamel remineralization and efficacy of dentinal tubules occlusion by tested formulations were investigated ex vivo on human hard tissues. All formulations containing Ca-P bioactive nanocompounds showed remineralizing ability by epitaxial growth of a layer showing the morphology and composition of human hydroxyapatite. Such layers also embedded nanosilica clusters. The presence of doping elements or casein phosphopeptide seemed essential to allow such performances, especially when hydroxyapatite and amorphous calcium phosphate compounds were doped with small amounts of CO32−, F−, Mg2+, and Sr2+. Topical mousse formulations showed a higher tubules occlusion capability than toothpastes, independently from their composition. Therefore, all tested formulations could be useful in restoring tooth structures in a biomimetic way, contrasting dental demineralization processes leading to caries.
Transparent and flexible passivation of MoS2/Ag nanowire with sputtered polytetrafluoroethylene film for high performance flexible heaters
Authors: Choi Seung-Gyun , Seok Hae-Jun , Kim Jihyun , Kang Joohoon , Kim Han-Ki 
Published: April 2022

AbstractWe demonstrated highly transparent and flexible polytetrafluoroethylene (PTFE) passivation for the MoS2/Ag nanowire (Ag NW) electrodes used in thin film heaters (TFHs). The electrical, optical, and mechanical properties of PTFE coated MoS2/Ag NW electrode were compared to the bare MoS2/Ag NW electrode to demonstrate effective passivation of the sputtered PTFE films before and after the 85 °C–85% temperature-relative humidity environment test. In addition, we investigated the performances of TFHs with PTFE/MoS2/Ag NW as a function of PTFE thickness from 50 to 200 nm. The saturation temperature (87.3 °C) of TFHs with PTFE/MoS2/Ag NW electrode is higher than that (61.3 °C) of TFHs with bare MoS2/Ag NW, even after the 85 °C–85% temperature-relative humidity environment test, due to effective passivation of the PTFE layer. This indicates that transparent PTFE film prepared by sputtering process provides effective thin film passivation for the two-dimensional (2D) MoS2 and Ag NW hybrid electrode against harsh environment condition.
Aryl hydrocarbon receptor and Krüppel like factor 10 mediate a transcriptional axis modulating immune homeostasis in mosquitoes
Authors: Kulkarni Aditi , Pandey Ashmita , Trainor Patrick , Carlisle Samantha , Yu Wanqin , Kukutla Phanidhar , Xu Jiannong 
Published: April 2022

AbstractImmune responses require delicate controls to maintain homeostasis while executing effective defense. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. The Krüppel-like factor 10 (KLF10) is a C2H2 zinc-finger containing transcription factor. The functions of mosquito AhR and KLF10 have not been characterized. Here we show that AhR and KLF10 constitute a transcriptional axis to modulate immune responses in mosquito Anopheles gambiae. The manipulation of AhR activities via agonists or antagonists repressed or enhanced the mosquito antibacterial immunity, respectively. KLF10 was recognized as one of the AhR target genes in the context. Phenotypically, silencing KLF10 reversed the immune suppression caused by the AhR agonist. The transcriptome comparison revealed that silencing AhR and KLF10 plus challenge altered the expression of 2245 genes in the same way. The results suggest that KLF10 is downstream of AhR in a transcriptional network responsible for immunomodulation. This AhR–KLF10 axis regulates a set of genes involved in metabolism and circadian rhythms in the context. The axis was required to suppress the adverse effect caused by the overactivation of the immune pathway IMD via the inhibitor gene Caspar silencing without a bacterial challenge. These results demonstrate that the AhR–KLF10 axis mediates an immunoregulatory transcriptional network as a negative loop to maintain immune homeostasis.
The influence of city development on urban pedodiversity
Authors: Pindral Sylwia , Kot Rafał , Hulisz Piotr 
Published: April 2022

AbstractThe aim of this study was to use a pedodiversity index (PI) to assess changes in the spatial structure of soil cover in Inowrocław, Poland during the twentieth and twenty-first centuries. An original cartographic approach based on landscape metrics was implemented using GIS techniques and statistical calculations. Based on maps of urban soil complexes and pedodiversity, it was revealed that land and soil cover changes in two studied periods (1934–1978 and 1978–2016) significantly affected pedodiversity in the city. In general, the spatio-temporal increase of the pedodiversity index was observed. The percentage of highest values of the PI ranged from 15.9% in 1934, 17.3% in 1978 to 20.9% in 2016. We revealed that pedodiversity index (PI) values are highly spatially and temporally variable and are associated with urban development and changes in the city’s internal structure. The applied approach allowed for the identification of both spatial patterns of changes in soil cover that closely reflect the successive stages of the city's development, and problem areas that require revitalization and the implementation of the principles of sustainable development. Therefore, the proposed method can be recommended for landscape monitoring and in determining ecosystem services in urban and landscape planning, and environmental management.
Production and characterization of a broad-spectrum antimicrobial 5-butyl-2-pyridine carboxylic acid from Aspergillus fumigatus nHF-01
Authors: Mandal Vivekananda , Ghosh Narendra Nath , Mitra Prashanta Kumar , Mandal Sukhendu , Mandal Vivekananda 
Published: April 2022

AbstractThe present study aims at the production optimization, purification, and characterization of a potent broad-spectrum antimicrobial compound (AMC) produced by Aspergillus fumigatus nHF-01 (GenBank Ac. No. MN190286). The culture conditions were optimized for a higher amount of AMC. The AMC was solvent extracted and characterized by UV–Vis, FT–IR, ESI–MS, and 1H-NMR spectroscopy. The MIC, MBC and mode of action were determined against a set of Gram-positive and Gram-negative human pathogenic bacteria. Its antibiofilm, synergistic and cytotoxic effects were also tested. The putative target site of action was evaluated through in silico molecular docking study. The stain A. fumigatus nHF-01 produced the maximum AMC (5-butyl-2-pyridine carboxylic acid) in 2% MEB (w/v) and 4% YE (w/v) at pH 6.0 and 20 °C temperature with 100 rpm agitation for ten days. It caused complete lethality of the Gram-positive and Gram-negative human pathogenic bacteria at a 129 µg/mL dose by rupture and entire dissolution of cell integrity. It showed moderate antibiofilm activity and had a synergistic activity with streptomycin and additive effects with ciprofloxacin and vancomycin. It targets a respiratory enzyme, Quinol-Fumarate Reductase (1l0v), with the highest binding affinities. It had cytotoxicity against human lung carcinoma A549 cell line and was stable up to 100 °C. Thus, the study revealed that the strain A. fumigatus nHF-01 produces a potent broad-spectrum AMC 5-butyl-2-pyridine carboxylic acid that could be used against human food and topical pathogenic bacteria. This is the first report of such a compound produced from the A. fumigatus.
Air2Land: A deep learning dataset for unmanned aerial vehicle autolanding from air to land
Authors: Zheng Xunchen , Hu Tianjiang 
Published: April 2022

AbstractIn this paper, a novel deep learning dataset, called Air2Land, is presented for advancing the state‐of‐the‐art object detection and pose estimation in the context of one fixed‐wing unmanned aerial vehicle autolanding scenarios. It bridges vision and control for ground‐based vision guidance systems having the multi‐modal data obtained by diverse sensors and pushes forward the development of computer vision and autopilot algorithms targeted at visually assisted landing of one fixed‐wing vehicle. The dataset is composed of sequential stereo images and synchronised sensor data, in terms of the flying vehicle pose and Pan‐Tilt Unit angles, simulated in various climate conditions and landing scenarios. Since real‐world automated landing data is very limited, the proposed dataset provides the necessary foundation for vision‐based tasks such as flying vehicle detection, key point localisation, pose estimation etc. Hereafter, in addition to providing plentiful and scene‐rich data, the developed dataset covers high‐risk scenarios that are hardly accessible in reality. The dataset is also open and available at https://github.com/micros‐uav/micros_air2land as well.The cover image is based on the Research Article Air2Land: A deep learning dataset for unmanned aerial vehicle autolanding from air to land by Tianjiang Hu et al., https://doi.org/10.1049/csy2.12045.
Reliability interdependencies and causality assessment for a converter‐penetrated power system
Authors: Zhang Bowen , Wang Mengqi , Su Wencong 
Published: April 2022

AbstractThis paper utilizes Bayesian network (BN) structure searching and scoring algorithms to identify critical nodes and investigate their reliability interdependencies for a power system under great converter penetration. As more converters are integrated into the system, reliability interactions among various converters will frequently emerge and consequently introduce system reliability concerns. However, reliability causal relations have rarely been explored and demonstrated in a clear manner. Therefore, the authors apply BN structure searching and scoring algorithms to visualize the proposed converter‐based BN structure. Moreover, reliability interactions among different nodes are quantified through information entropy theory. Numerical case studies illustrate the causal reliability relationship among various nodes while considering the reliability of all integrated converters. Critical nodes are identified such that system operators can improve the converter maintenance scheduling.
A new pilot protection scheme for modular multi‐level converter‐based HVDC system based on voltage matching factor
Authors: Ma Jing , Xiao Zhaohang , Li Yongli , Zhang Jun , Wu Bin , Li Zhenbin , Ma Ruichen , Huang Weibo , Cheng Peng 
Published: April 2022

AbstractConcerning the incorrect operation of line protection in modular multi‐level converter‐based multi‐terminal DC system, a pilot protection method based on voltage matching factor is proposed. First, the dynamic switching process of flexible DC converter sub‐module is analyzed, and the expression of DC voltage of converter station considering the influence of alternating current (AC) system is derived. On this basis, the model of DC line voltage considering the influence of AC injection current is built, and the equivalent DC line voltage is calculated according to the voltage model. Then, by constructing the distortion factor which reflects the difference between the equivalent DC line voltage and actual DC line voltage, the protection criterion for the identification of internal and external faults is established. Finally, simulation tests on real time laboratory (RT‐LAB) platform verify that the proposed scheme can correctly distinguish between internal and external faults in different fault cases, with fast operation speed and strong immunity to the fault resistance.