bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of an individualized home-based physical activity program in surgery-free non-endarterectomized asymptomatic stroke patients: a study protocol for the PACAPh interventional randomized trial
Authors: Mura Mathilde , Rivoire Emeraude , Dehina-Khenniche Leila , Weiss-Gayet Michèle , Chazaud Bénédicte , Faes Camille , Connes Philippe , Long Anne , Rytz Chantal L. , Mury Pauline , Delrieu Lidia , Gouraud Etienne , Bordet Marine , Della Schiava Nellie , Lermusiaux Patrick , Arsicot Matthieu , Millon Antoine , Pialoux Vincent 
Published: February 2022

Abstract
Background
Carotid atherosclerotic plaques remain silent until their rupture, which may lead to detrimental ischemic events such as strokes. This is due, in part, to intraplaque hemorrhages (IPH) and the resulting inflammatory processes, which may promote carotid plaque vulnerability. Currently, the benefits of carotid endarterectomy remain unclear for asymptomatic patients. Interestingly, the completion of physical activity (PA) may have beneficial effects; however, the paucity of current data warrants robust longitudinal interventions. We therefore aim to study the effects of a 6-month longitudinal personalized home-based PA program on IPH, biological, and inflammatory markers in asymptomatic stroke patients.

Methods
Eighty patients (≥ 18 years old) will be recruited for the Physical Activity and Carotid Atherosclerotic Plaque Hemorrhage (PACAPh) clinical trial from the Hospices Civils de Lyon. Patients will be eligible if they present with carotid stenosis ≥ 50% and are asymptomatic from any ischemic events for at least 6 months. Recruited patients will be randomized into either a PA or a control group, and assessed at baseline and after 6 months. At both time points, all patients will be assessed using magnetic resonance imaging to assess IPH, blood sampling to measure inflammatory markers and monocytic phenotyping, PA and sedentary behavior questionnaires, 6-min walking test, and maximal isometric quadricep contraction test. The randomized PA intervention will consist of reaching a daily walking step goal individually tailored to each patient. Steps will be collected using a wirelessly connected wristband. The number of steps completed by individuals in the PA group will be re-evaluated bimonthly to encourage walking habits.

Discussion
The PACAPh study is the first of its kind representing a feasible, easily accessible therapeutic strategy for asymptomatic stroke patients. We hypothesize that the personalized home-based PA program will reduce IPH and modulate inflammatory and biological parameters in patients presenting with carotid plaques. If the results of the PACAPh study prove to be beneficial on such health parameters, the implementation of such kind of intervention in the daily treatment of these patients would be an advantageous and cost-effective practice to adopt globally.

Trial registration
This study has been approved by the National Ethics Committee (IDRCB:2019-A01543-54/SI:19.06.21.40640). ClinicalTrials.gov NCT04053166
Autism and chronic ill health: an observational study of symptoms and diagnoses of central sensitivity syndromes in autistic adults
Authors: Grant Sarah , Norton Sam , Weiland Ricarda F. , Scheeren Anke M. , Begeer Sander , Hoekstra Rosa A. 
Published: February 2022

Abstract
Background
Autistic adults, particularly women, are more likely to experience chronic ill health than the general population. Central sensitivity syndromes (CSS) are a group of related conditions that are thought to include an underlying sensitisation of the central nervous system; heightened sensory sensitivity is a common feature. Anecdotal evidence suggests autistic adults may be more prone to developing a CSS. This study aimed to investigate the occurrence of CSS diagnoses and symptoms in autistic adults, and to explore whether CSS symptoms were related to autistic traits, mental health, sensory sensitivity, or gender.

Methods
The full sample of participants included 973 autistic adults (410 men, 563 women, mean age = 44.6) registered at the Netherlands Autism Register, who completed questionnaires assessing autistic traits, sensory sensitivity, CSS, physical and mental health symptoms. The reliability and validity of the Central Sensitization Inventory (CSI) in an autistic sample was established using exploratory and confirmatory factor analyses. Chi2 analyses, independent t-tests, hierarchical regression and path analysis were used to analyse relationships between CSS symptoms, autistic traits, measures of mental health and wellbeing, sensory sensitivity, age and gender.

Results
21% of participants reported one or more CSS diagnosis, and 60% scored at or above the clinical cut-off for a CSS. Autistic women were more likely to report a CSS diagnosis and experienced more CSS symptoms than men. Sensory sensitivity, anxiety, age and gender were significant predictors of CSS symptoms, with sensory sensitivity and anxiety fully mediating the relationship between autistic traits and CSS symptoms.

Limitations
Although this study included a large sample of autistic adults, we did not have a control group or a CSS only group. We also could not include a non-binary group due to lack of statistical power.

Conclusions
CSS diagnoses and symptoms appear to be very common in the autistic population. Increased awareness of an association between autism and central sensitisation should inform clinicians and guide diagnostic practice, particularly for women where CSS are common and autism under recognised.
Generalization of Montgomery identity via Taylor formula on time scales
Authors: Malik Sumaiya , Khan Khuram Ali , Nosheen Ammara , Awan Khalid Mahmood 
Published: February 2022

AbstractIn the current paper, a generalized Montgomery identity is obtained with the help of Taylor’s formula on time scales. The obtained identity is used to establish Ostrowski inequality, mid-point inequality, and trapezoid inequality. Moreover, the weighted versions of generalized Montgomery identity and respective Ostrowski inequality are also discussed. Special cases are obtained for different time scales to obtain new and existing results.
Internal feedback stabilization of multi-dimensional wave equations with a boundary delay: a numerical study
Authors: Ammari Kaïs , Chentouf Boumediène , Smaoui Nejib 
Published: February 2022

AbstractIn this paper, we consider two internal stabilization problems for the multi-dimensional wave equation with a boundary time-delay. We prove that the first problem is well-posed in an appropriate functional space. Subsequently, we numerically study the exponential stability in a two-dimensional case under Geometric Control Condition (GCC) derived by Lebeau. In addition, we provide a numerical investigation of the second wave system, which corresponds to the two-dimensional variant of the system studied by Datko et al.
Numerical and Empirical Models for Service Life Assessment of RC Structures in Marine Environment
Authors: Chen Xuandong , Ming Yang , Fu Feng , Chen Ping 
Published: February 2022

AbstractThe service life prediction of reinforced concrete (RC) structures in marine environment is essential in structural repair and health monitoring. In this paper, a numerical model for predicting the service life of reinforced concrete is first developed which considering the time-varying boundary of chloride concentration, critical chloride concentration and density of corrosion current. Based on the model, the effects of water–cement ratio, reinforcement diameter, concrete cover thickness and critical chloride ion concentration on the service life and deterioration duration of RC structures are investigated. The key factors affecting the service life of reinforced concrete structures are determined. More importantly, based on regression analysis, a new simplified empirical model for predicting the service life of RC structures is also developed. It provides a fast assessment tool for practical engineers. Both the numerical model and empirical model validated are suitable for practical engineering applications. The results show that with the increase of water–cement ratio, the service life of reinforced concrete structure decreases exponentially. And with the increase of the thickness of the concrete cover, the service life, deterioration duration, and safety reserve increase linearly. However, the influence of the diameter of the reinforcing bar on the service life can be ignored.
Economic and emotional impact of COVID-19 pandemic on phoniatricians’ practice in Egypt
Authors: Ibrahim Aisha Fawzy Abdel Hady , Sheikhany Ayatallah Raouf 
Published: February 2022

Abstract
Background
COVID-19 is not only a health crisis; it has the potential to create devastating social, as well as economic crises. Health care practitioners are the category with the highest diffusion of the contagion. The aim was to determine the economic and emotional impact of the COVID-19 pandemic on phoniatricians in Egypt in an attempt to analyze this data to determine the magnitude of this effect and if it is age and/or location specific.

Subjects and methods
An online structured Google-free form survey composed of 49 questions was created and sent online to phoniatricians all over Egypt. The survey was divided into three sections about demographic, economical then emotional-related questions. The studied group was further subdivided into 2 groups according to age and location for comparison purposes.

Results
82.5% of phoniatricians confirmed that the pandemic had a lot of negative impact on their practice. About 37.5% reduced their practices to urgent procedures and the same percentage closed their practice. The expenses of 56.3% exceeded their income. 91.2% had negative feelings when thinking about the pandemic. The economic problems have affected 71.3% of the participants emotionally. The pandemic had comparable negative impact on the economic and emotional aspects of both age groups. However, the younger age group suffered more from getting infected, and they thought more about career shift and was the group that needed psychological support during the pandemic. Outside Cairo organizations succeeded in providing the personal protective equipment to the phoniatricians in comparison to Cairo.

Conclusion
COVID-19 had a negative effect on the economical and emotional aspects of Egyptian phoniatricians’ lives. The pandemic economic burden was related to quarantine period, heath problems and getting infected, family requirements, and purchasing the protective equipment. The emotional burden was related most to the pandemic hazards and financial effect on the clients and chance of losing job. Few effects were age- and location-specific.
The current state of acute oncology training for emergency physicians: a narrative review
Authors: Bischof Jason J. , Caterino Jeffrey M. , Creditt Angela B. , Wattana Monica K. , Pettit Nicholas R. 
Published: February 2022

AbstractPatients with cancer represent a growing population of patients seeking acute care in emergency departments (ED) nationwide. Emergency physicians are expected to provide excellent, consistent care to all ED patients; however, emergency medicine (EM) education and training of acute oncology is lacking.To explore this topic, the Society for Academic Emergency Medicine Oncologic Emergencies Interest Group recruited experts in the field to provide a narrative description of the current state of EM education relating to acute oncology. This review of expert opinions explores the current state of acute oncology education in EM and identifies key content gaps that merit early investment.Current emergency physician training and knowledge relating to acute oncology likely reflects the American Board of Emergency Medicine Model of Clinical Practice. Key topics such as immunotherapy are absent from the most recent revision of the Model of Clinical Practice and consequently represent a knowledge gap for large numbers of emergency physicians. Additionally, there is limited penetration of guideline-based care for symptom management in the ED setting. As such, additional attention should be provided to training programs and research efforts to address these knowledge gaps.In conclusion, the current state of acute oncology education and training of emergency physicians is lacking and merits significant investment to assure the ability of emergency physicians to provide superior care for the growing population of patients with cancer.
Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage
Authors: Major Ajay , Palese Monica , Ermis Ebru , James Anthony , Villarroel Milena , Klussmann Federico Antillon , Hessissen Laila , Geel Jennifer , Khan Muhammad Saghir , Dalvi Rashmi , Sullivan Michael , Kearns Pamela , Frazier A. Lindsay , Pritchard-Jones Kathy , Nakagawara Akira , Rodriguez-Galindo Carlos , Volchenboum Samuel L. 
Published: February 2022

PURPOSEThe global pediatric oncology clinical research landscape, particularly in Central and South America, Africa, and Asia, which bear the highest burden of global childhood cancer cases, is less characterized in the literature. Review of how existing pediatric cancer clinical trial groups internationally have been formed and how their research goals have been pursued is critical for building global collaborative research and data-sharing efforts, in line with the WHO Global Initiative for Childhood Cancer.METHODSA narrative literature review of collaborative groups performing pediatric cancer clinical research in each continent was conducted. An inventory of research groups was assembled and reviewed by current pediatric cancer regional and continental leaders. Each group was narratively described with identification of common structural and research themes among consortia.RESULTSThere is wide variability in the structure, history, and goals of pediatric cancer clinical trial collaborative groups internationally. Several continental regions have longstanding endogenously-formed clinical trial groups that have developed and published numerous adapted treatment regimens to improve outcomes, whereas other regions have consortia focused on developing foundational database registry infrastructure supported by large multinational organizations or twinning relationships.CONCLUSIONThere cannot be a one-size-fits-all approach to increasing collaboration between international pediatric cancer clinical trial groups, as this requires a nuanced understanding of local stakeholders and resources necessary to form partnerships. Needs assessments, performed either by local consortia or in conjunction with international partners, have generated productive clinical trial infrastructure. To achieve the goals of the Global Initiative for Childhood Cancer, global partnerships must be sufficiently granular to account for the distinct needs of each collaborating group and should incorporate grassroots approaches, robust twinning relationships, and implementation science.
Curious Effect of Isotope-Labelled Substrate/Co-Enzyme on Catalytic Activity of CO2 Reduction by Formate Dehydrogenase from Candida Boidinii
Authors: Sato Ryohei , Amao Yutaka 
Published: February 2022

Abstract
The effects of isotope-labelled NADH and CO2 on formate dehydrogenase from Candida boidinii (CbFDH)-catalyzed CO2 reduction activity were investigated. It was found that the rate of CO2 reduction to formate with CbFDH decreased by using deuterium-labelled NADH (NADH-d4) as a co-enzyme. In contrast, the rate of CbFDH-catalyzed CO2 reduction to formate was unchanged in the use of 13CO2 as a substrate. In the substrate 12CO2 and 13CO2 is mixed, however, curious phenomenon on CbFDH-catalyzed CO2 reduction activity decrease was observed.
Case Report: Ovarian metastasis revealing primary gall bladder carcinoma
Authors: Bettaieb Hajer , Souayeh Nesrine , Ben Nar Mehdi , Mezghani Sana , Khanchel Fatma , Mbarki Wael , Laifi Safa , Helal Imen , Oueslati Hedhili , Hsayaoui Najeh , Mbarki Chaouki 
Published: February 2022

Ovaries can be an elective metastatic site for many cancers mostly in gastrointestinal tract, breast and endometrial cancers. Gallbladder and bile ducts cancers are rare, accounting for few ovarian metastatic tumors. We report a case of bilateral metastatic ovarian of gallbladder carcinoma in a 44 years old woman. Patient had pelvic pain, anorexia, weight loss and decreased visual acuity. Imagery showed bilateral ovarian tumor and polyp in the gallbladder. Furthermore, there were metastasis to the liver, lungs and choroid plexus. Liver biopsy confirmed the metastatic origin from gallbladder cancer. Patient underwent surgery. She had total hysterectomy with bilateral oophorectomy, omentectomy and cholecystectomy. She passed away six months later, after refusing additional adjuvant therapy.
Desire, acceptability, and expected resolution: A latent class analysis of current pregnancy orientation in the United States
Authors: Arcara Jennet , Caton Lauren , Gómez Anu Manchikanti 
Published: February 2022

AbstractBackgroundScant research has examined latent and contextual dimensions of pregnancy intentions, conventionally classifying unintended pregnancies as mistimed (wanted later) or unwanted (not wanted at all). Being at risk of mistimed pregnancy likely encompasses a broad spectrum of emotions and expectations regarding pregnancy and merits further exploration.MethodUsing a national sample from GfK's online KnowledgePanel of women aged 15–39 considered at risk of mistimed pregnancy in 2017 (n = 1278), we conducted a latent class analysis to assess underlying patterns of current pregnancy orientation using three items: pregnancy desire, pregnancy acceptability, and expected pregnancy resolution. As class structure varied by relationship status (serious or not), we stratified analyses by relationship status.ResultsAmong women in serious relationships, three classes emerged: “No,” “Slightly okay,” and “Acceptable.” For those not in serious relationships, there were two classes: “Strong no” and “Ambiguous.” Overall, the classes indicate varied patterns of wantedness, acceptability, and anticipated resolution to potential pregnancy.ConclusionsThis analysis reinforces that the construct of mistimed pregnancy is too restrictive to reflect the inherent diversity of prospective pregnancy orientation. The combination of relationship type as a grouping variable for stratified analyses, financial hardships' impact, and the overall effect of increasing age on increasing interest in pregnancy suggest the importance of locating pregnancy intentions within the broader reproductive life course. Scholars, clinicians, and public health programs should allow for multidimensionality of pregnancy perspectives, locate them within the broader life course, and acknowledge the potential impacts of stratified relationship formation on eventual pregnancy intentions.
FAKTOR-FAKTOR YANG MEMPENGARUHI BURNOUT PADA TENAGA KESEHATAN INSTALASI PELAYANAN RADIOLOGI DAN KEDOKTERAN NUKLIR RSUPN CIPTO MANGUNKUSUMO TAHUN 2021
Authors: Astuti Dita Ayu , Hernaya Ade , Nabila Anggun , Kusumaningtiar Devi Angeliana 
Published: February 2022

Health workers are workers who play an important role in hospitals, with daily work dealing with patients. Burnout syndrome is often found in professions that are human service, such as health workers. Burnout is exhaustion both physically, emotionally and mentally as a result of long-term involvement in situations with emotional demands. The purpose of this study was to determine the factors that influence burnout of health workers at the Radiology and Nuclear Medicine Service Installation at Cipto Mangunkusumo General Hospital. The type of research used is cross sectional with a quantitative approach. The study was conducted in July – September 2021. The population and sample were 66 health workers with total sampling method. Data analysis was carried out using univariate and bivariate tests using the chi-square statistical test with = 0.05. The conclusion from the results of this study is that health workers experienced high burnout by 36 pople (57,1 %), 27 people low burnout (42,9 %), health workers with a working period of 5 years 53 people (84.1%), years of service <5 years 10 people (15.9 %), very high workload 33 people (52.4 %), high workload 23 people (36.5 %), low workload 7 people (11.1% %), low social support 40 people (63.5 %), and high social support 23 people (36.5 %). Based on bivariate analysis, it was found that there was a relationship between burnout and workload (p-value = 0.028, with PR = 2.563). The risk factors for burnout of health workers in this study were years of work, workload, and social support
A study of highly efficient stochastic sequences for multidimensional sensitivity analysis
Authors: Dimov Ivan , Todorov Venelin , Sabelfeld Karl 
Published: February 2022

AbstractIn this paper, we present and study highly efficient stochastic methods, including optimal super convergent methods for multidimensional sensitivity analysis of large-scale ecological models and digital twins. The computational efficiency (in terms of relative error and computational time) of the stochastic algorithms for multidimensional numerical integration has been studied to analyze the sensitivity of the digital ecosystem, namely the UNI-DEM model, which is particularly appropriate for connecting and orchestrating the many autonomous systems, infrastructures, platforms and data that constitute the bedrock of predicting and analyzing the consequences of possible climate changes. We deploy the digital twin paradigm in our consideration to study the output to variation of input emissions of the anthropogenic pollutants and to evaluate the rates of several chemical reactions.
Recursive regression estimation based on the two-time-scale stochastic approximation method and Bernstein polynomials
Authors: Slaoui Yousri , Helali Salima 
Published: February 2022

Abstract
In this paper, we propose a recursive estimators of the regression function based on the two-time-scale stochastic approximation algorithms and the Bernstein polynomials. We study the asymptotic properties of this estimators. We compare the proposed estimators with the classic regression estimator using the Bernstein polynomial defined by Tenbusch. Results showed that, our proposed recursive estimators can overcome the problem of the edges associated with kernel regression estimation with a compact support. The proposed recursive two-time-scale estimators are compared to the non-recursive estimator introduced by Tenbusch and the performance of the two estimators are illustrated via simulations as well as two real datasets.
SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis
Authors: Zhang Jianxin , Shen Yanbing , Ma Dandan , Li Zhonghu , Zhang Zhiyong , Jin Weidong 
Published: February 2022

Abstract
In this study, we intended to figure out the biological significance of long non-coding RNAs (lncRNAs) solute carrier organic anion transporter family member 4A1 antisense RNA 1 (SLCO4A1-AS1) in pancreatic cancer (PC). Cell counting kit-8, colony formation, wound healing, transwell, and flow cytometry experiments were performed to reveal how SLCO4A1-AS1 influences PC cell proliferation, migration, invasion, and apoptosis. Thereafter, bioinformatics analysis, RNA immunoprecipitation assay, luciferase reporter assay, and RNA pull-down assay were applied for determining the binding sites and binding capacities between SLCO4A1-AS1 and miR-4673 or kinesin family member 21B (KIF21B) and miR-4673. The results depicted that SLCO4A1-AS1 was upregulated in PC, and SLCO4A1-AS1 knockdown suppressed PC cell growth, migration, invasion, and induced cell apoptosis. Furthermore, SLCO4A1-AS1 was verified to modulate the expression of KIF21B by binding with miR-4673. SLCO4A1-AS1 exerted an oncogenic function in PC. The overexpression of SLCO4A1-AS1 aggravated the malignant behaviors of PC via the upregulation of KIF21B by sponging miR-4673. Our findings revealed a novel molecular mechanism mediated by SLCO4A1-AS1, which might play a significant role in modulating the biological processes of PC.