bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a chair positioning session in awake non-intubated COVID-19 pneumonia patients: a multicenter, observational, pilot study using lung ultrasound
Authors: Lopez Alexandre , Simeone Pierre , Delamarre Louis , Duclos Gary , Arbelot Charlotte , Lakbar Ines , Pastene Bruno , Bezulier Karine , Dahan Samuel , Joffredo Emilie , Jay Lucille , Velly Lionel , Allaouchiche Bernard , Hraiech Sami , Leone Marc , Zieleskiewicz Laurent 
Published: March 2022

Abstract
BackgroundLung ultrasound (LUS) is a validated tool for the management of coronavirus disease 2019 (COVID-19)-related pneumonia. An awake prone positioning (PP) improves oxygenation and outcomes in COVID-19 non-intubated patients, but its tolerance remains an issue. A chair positioning (CP) may have beneficial effects on oxygenation and lung aeration. Thus, CP could be an easier alternative to PP. This study assessed the effects of a CP session on oxygenation (using SpO2:FiO2 ratio) and lung aeration (using lung reaeration score) changes in non-intubated COVID-19 patients. Methods An observational multicenter study was conducted in three university hospital intensive care units (ICUs). We retrospectively analyzed prospectively collected data from LUS exams performed before and after a CP session in non-intubated COVID-19 patients. Patients were divided into groups of responders or non-responders in terms of oxygenation and lung aeration.ResultsOf the 33 patients included in the study, 14 (44%) were oxygenation non-responders and 18 (56%) were oxygenation responders, and 13 (40.6%) and 19 (59.4%) patients were classified as lung aeration non-responders and responders, respectively. Changes in oxygenation and lung aeration before and after a CP session were not correlated (Pearson’s r = -0.19, p = 0.3, 95% CI: -0.5–0.17). The reaeration scores did not differ between oxygenation responders and non-responders (1 [-0.75–3.75] vs. 4, [-1–6], p = 0.41). The LUS score was significantly correlated with SpO2:FiO2 ratio before a CP session (Pearson’s r = 0.37, p = 0.04, 95% CI: 0.03–0.64) but not after (Pearson’s r = 0.17, p = 0.35, 95% CI: -0.19–0.50). Conclusion A CP session was associated with improved oxygenation and lung aeration in more than half of the non-intubated COVID-19 patients. However, oxygenation and lung aeration changes were not associated, suggesting that a CP session induces a ventilation:perfusion matching alteration.
Design and Synthesis of Novel 3- Arylil 2-oxindole for Sirtuin 2 Inhibition
Authors: Arabi Mehdi Sheikh , Asadi Pouyan , Khajeniazi Safoura 
Published: March 2022

Abstract
Class III histone deacetylases (sirtuins) have essential roles in many cellular processes. They are related to prolonged longevity and to the cancer pathogenesis and neuronal illnesses. Sirtuin 2 inhibition as a vital enzyme which are involved in overexpression and the process of aging, rise the lifespan of yeasts. According to the signs, these enzymes are incorporated in causing viral disorders and also mediate cancer. Although today potent inhibitors of SIRT2 are existing, 3-Arylideneindolin-2-ones byproducts as potent compounds with least side effects and high efficiency have been defined as the candidate for a new generation of SIRT2 inhibitors. In computational study, sunitinib was used as the template for reference drug. Molecular docking to identify potential hit compounds carried out. So as to confirm our hit compounds, molecular dynamics simulations and related analysis were done and the findings propose that our hit compound which can be potential inhibitors of the sirtuin 2. Novel sirtuin 2 inhibitors based on a 6,7-dichloro-2-oxindole scaffold with low micromolar activity are presented. In vitro activity was justified by docking studies, and sirtuin 2 targets hyperacetylation could be exhibited in cell culture.
Workforce situation of the Chinese mental health care system: results from a cross-sectional study
Authors: Yue Jing-Li , Li Na , Que Jian-Yu , Hu Si-Fan , Xiong Na-Na , Deng Jia-Hui , Ma Ning , Sun Si-Wei , Chi Rui , Shi Jie , Sun Hong-Qiang 
Published: March 2022

Abstract
Background High-quality mental health services can improve outcomes for disabled people with mental health problems and abate the burden of mental disorders. We sought to identify the challenges the country’s mental health system currently faces and provide recommendations on how the human resource situation in mental health could be addressed in China.Methods This study used a cross-sectional survey design. A web-based questionnaire approach and a convenience sampling method were adopted. It was carried out from September 2020 to January 2021 in China and we finally included 3824 participants in analysis. Descriptive statistical analysis of characteristics of study sample was performed. The risk factors for competence in psychological counseling/psychotherapy was assessed using multiple linear regression analysis. Results Workforces related to psychotherapy are scarce in China, especially in Western China and community mental health sectors. Psychiatrists (39.1%) and nurses (38.9%) were the main service providers of psychotherapy in psychiatric hospitals, and clinical psychologists (6.9%) and counsellors (5.0%) were seriously scarce in mental health care sectors. A total of 74.2% of the respondents had no systematic psychological training, and 68.4% and 69.2% of them had no self-experience and professional supervision respectively. Compared with clinical psychologists and counsellors, psychiatrists and nurses had less training. Systematic psychological training (β = -0.884), self-experience (β = -0.586) and professional supervision (β = -1.260) significantly influenced psychotherapy capacity (P＜0.001).Conclusions Sustained effort will be required to provide a high-quality, equitably distributed psychotherapy mental health workforce in China, despite challenges for community mental health sectors and western China being likely to continue for some time. Because mental illness is implicated in so many burgeoning social ills, addressing this shortfall could have wide-ranging benefits.
A comprehensive study of Iraqi marshlands, with the emphasis on the development possibilities
Authors: Alani Mina A. , Shen Jie , Koko Auwalu Faisal 
Published: March 2022

Abstract
Iraqi Marshes is one of the most important historical heritage in Iraq and in the middle east, it has a very important geographical location and unique architecture and landscape design. For many years, Iraqi marshlands was always appealing to the scholars from all around the word. In 2016, marshlands had been inscribed on the “World Heritage List” during the 40th session if the World Heritage Committee. Marshland’s Inhabits usually enjoy a very unique life style. This area have different kind of animal, birds, and plants. Back in the 90s, there was a destructive action that done by the former Iraqi government which involves drainage of the marshlands, that led the inhabitants to leave the area. After 2003 there was a refolding of the marshlands, however, despite the cultural and historical importance of the marshlands, until now this area is still neglected and not getting the enough attention for development, the paper focus on investigating and fully analyses these area using data collection from literature review for the possibilities of future development and emphasizing the importance of the environmental tourism that can play a major role in Iraq’s national income. The result of the research has shown a poor managements to the marshland, there is no any governmental plans to develop the marshlands. Thus we should shed a light on this area and put its development into consideration.
miR-539-5p inhibits proliferation and invasion of gallbladder cancer cells by targeting BACH1
Authors: Fang Jian , Zhu Huifen , Xu Pengcheng , Jiang Renya 
Published: March 2022

Abstract
Background: Gallbladder cancer (GBC) is a common biliary tract malignancy worldwide, with no definite molecular-targeted treatment. Previous studies have shown that miR-539-5p was observed to be aberrantly expressed in multiple tumors and was associated with the occurrence and progression of human cancers. However, the functional role and exact mechanism of miR-539-5p in GBC progression remain barely known.Methods: The expression of miR-539-5p and BACH1 in GBC tissues and cell lines was detected by qRT-PCR. Western blotting was utilized to detect the protein level of BACH1. CCK-8 assay, colony formation assay, and Transwell assay was employed to evaluate GBC cell proliferation and invasion. Dual-luciferase reporter gene assay was utilized to verify the target relationship between miR-539-5p and BTB domain and CNC homolog 1 (BACH1). Xenograft tumor experiments were conducted on nude mice to confirm antitumor effect of miR-539-5p on GBC in vivo.Results: Our results showed that miR-539-5p was downregulated in GBC tissues and cell lines. Overexpression of miR-539-5p significantly suppressed the proliferation and invasion abilities of GBC cells. Dual-luciferase reporter gene assay confirmed that BACH1 was a target gene of miR-539-5p. Moreover, knockdown of BACH1 exhibited anti-proliferation and anti-invasion effects on GBC cells. Mechanistically, miR-539-5p suppressed the malignant behaviors of GBC cells, which were largely counteracted by the overexpression of BACH1. In vivo experiments, miR-539-5p overexpression tremendously repressed GBC tumor growth.Conclusion: miR-539-5p inhibited GBC progression via directly targeting BACH1, which can be served as potential treatment targets against the progression of GBC.
Effect of thermal treatment at high temperature on phase stability and transformation of Yb2O3 and Y2O3 co-doped ZrO2 ceramics
Authors: Cao Zheng , An Shengli , Song Xiwen 
Published: March 2022

Abstract
Y2O3 doped ZrO2 (YSZ) ceramic material is used to protect alloy components worked in high-temperature. But its phase transformation occurred at high temperate leads to YSZ invalid. This study explored the process of phase changes of YSZ at high temperature. Besides, the phase stability and transformation details of Yb2O3 and Y2O3 co-doped ZrO2 (YbYSZ) ceramics were also discussed. The ceramic samples were synthesized using a solid-state reaction method. The results of X-ray diffraction and Raman spectra displayed that all bulks exhibited almost the same crystal structure. The phase transformation investigation through the thermal treatment at 1300 °C demonstrated that YbYSZ ceramics had better phase stability than YSZ. The content of the monoclinic phase calculated according to X-ray diffraction of ceramic samples heat-treated at 1300 °C for 0 – 358 hours showed a sigmoidal behavior. The content change of monoclinic phase of YbYSZ ceramics with heat treatment time at 1300 °C can be divided into three stages: (I) diffusion progress accompany by the transformation of t′→t+c→t+c+m, (II) drastic change from tetragonal phase to monoclinic phase, and (III) the content of monoclinic phase gets saturation.
Polarization-entangled photon pairs in the visible spectral band using intermodal spontaneous four-wave mixing
Authors: Lee Ju Han , Lee Kyungtaek , Jung Junha 
Published: March 2022

Abstract
The theoretical and experimental investigation results of the generation of the polarization-entangled photon pairs operating at visible wavelengths are reported. The generation of polarization-entangled photon pairs was based on intermodal spontaneous four-wave mixing (IM-SFWM) using standard step-index few-mode fiber. It was shown theoretically that several combinations of IM-SFWM processes could occur depending on spatial modes of a pump beam. A polarization-entangled photon pair source based on Sagnac loop incorporating a segment of few-mode fiber were then experimentally created. A two-photon interference fringe visibility of our implemented photon pair source were 91.7% and 88.8% in H/V bases and D/A bases, respectively. A quantum state tomography was also conducted to reconstruct the density matrix of the generated state with a fidelity to a maximum entangled state of 93.1%.
Research Polyphenylene Sulfide Fiber-Reinforced Elastic Wheel Polishing based on Soft Consolidation Abrasive
Authors: yisen zeng , xi zeng 
Published: March 2022

Abstract
In industry 4.0 background, traditional technical industry is mentioned more and more times. Technological innovation has been advanced in precision-machine internationally. Faced to remained peak of surface layer distributed non-uniformly, this article proposes polyphenylene sulfide fiber-reinforced method to get highly sophisticated surface. Based on different hard matrix rubber of wheels, fiber added into wheels to improve elastic modulus and guarantees abrasive particles which contacts with workpiece distributed evenly while polishing. This method reduces scratches and avoids subsurface damage when wheel polishes in declining angle. Compared to different proportional fiber, two hard wheels in 5% fiber can get smoother and parallel surface when wheel rotates in high speed. Predicted model of rubber built based on Halpin-Tsai empirical formula, which displays elastic modulus of fiber is much higher than matrix rubber and adds polyphenylene sulfide can enhance anti-truncation ability of wheel exponentially. Rubber surface layer supports soft consolidation abrasive elastically to ensure particles arranged horizontally which can be reflected from observing deformation and stress of wheel by ansys. This phenomenon called elastic support that guarantees every particle have same volume material removed on contact area to get smoother surface. In following polishing experiments, carbide surface polished by 5% fibrous elastic wheel is the best among 0%, 2% ,4% and 5% polyphenylene sulfide. Fiber-reinforced elastic wheel surely promotes carbide polished effectively.
Histological Manifestations of Diabetic Kidney Disease and its Relationship
with Insulin Resistance
Authors: Adeva-Andany María M. , Adeva-Contreras Lucía , Fernández-Fernández Carlos , Carneiro-Freire Natalia , Domínguez-Montero Alberto 
Published: March 2022

Abstract:
Histological manifestations of diabetic kidney disease (DKD) include mesangiolysis,
mesangial matrix expansion, mesangial cell proliferation, thickening of the glomerular basement
membrane, podocyte loss, foot process effacement, and hyalinosis of the glomerular arterioles, interstitial
fibrosis, and tubular atrophy. Glomerulomegaly is a typical finding. Histological features
of DKD may occur in the absence of clinical manifestations, having been documented in patients
with normal urinary albumin excretion and normal glomerular filtration rate. Furthermore, the histological
picture progresses over time, while clinical data may remain normal. Conversely, histological
lesions of DKD improve with metabolic normalization following effective pancreas transplantation.
Insulin resistance has been associated with the clinical manifestations of DKD
(nephromegaly, glomerular hyperfiltration, albuminuria, and kidney failure). Likewise, insulin resistance
may underlie the histological manifestations of DKD. Morphological changes of DKD are
absent in newly diagnosed type 1 diabetes patients (with no insulin resistance) but appear afterward
when insulin resistance develops. In contrast, structural lesions of DKD are typically present before
the clinical diagnosis of type 2 diabetes. Several heterogeneous conditions that share the occurrence
of insulin resistance, such as aging, obesity, acromegaly, lipodystrophy, cystic fibrosis,
insulin receptor dysfunction, and Alström syndrome, also share both clinical and structural manifestations
of kidney disease, including glomerulomegaly and other features of DKD, focal segmental
glomerulosclerosis, and C3 glomerulopathy, which might be ascribed to the reduction in the
synthesis of factor H binding sites (such as heparan sulfate) that leads to uncontrolled complement
activation. Alström syndrome patients show systemic interstitial fibrosis markedly similar to that
present in diabetes.
Inferior Vena Cava Agenesis Associated with Urogenital Anomalies: A
Case Report
Authors: Atay Musa , Kocakoc Ercan 
Published: March 2022

Background:
Inferior vena cava (IVC) agenesis, ectopic ureterocele, and ureteral duplication
are very rare congenital anomalies.

Case Presentation:
A-25-year-old female patient was referred with right flank pain, chills and dysuria.
Laboratory tests and CT showed findings consistent with acute pyelonephritis. The medical history
revealed only frequent urinary tract infections and Factor V Leiden mutation. The patient was treated
with antibiotherapy. CT examination demonstrated IVC agenesis (IVCA). Urogenital anomalies such
as vaginal ectopic ureterocele, ureteral duplication and septate uterine anomaly were also present.

Conclusion:
We report the first occurrence of IVC agenesis associated with multiple urogenital anomalies
in the literature.
An Electronic Evaluation of Symptoms in People of India Post-COVID-19
Vaccination
Authors: Kamboj Sweta , Kamboj Rohit , Kamboj Shikha , Dutt Rohit , Guarve Kumar , Bansal Kamal , Rohila Vivek 
Published: March 2022

Background:
Remarkable and groundbreaking performances of scientists all over the
globe have led to the evolution of COVID-19 vaccines, which are extensively viewed as means to
control the epidemic. The primary purpose of this research work was to discover the major side effects
of the vaccines, mainly in Homo sapiens.

Methods:
An online survey was conducted in various cities of Haryana, India, using a trial version
of QualtricsCoreXM software to prototype 20 questionnaires.

Result:
In the survey, 200 candidates participated, among which 83.5% had received Covishield
and 16.5% had been vaccinated with Covaxin. Overall 65% of respondents have reported side effects.
The major side effects reported were fever, tiredness, myalgia, diarrhea, headache, etc.

Conclusion:
Succeeding the survey related to the effects of COVID-19 vaccine on non-identical
Homo sapiens, generally with respect to their perspective regarding the symptoms of vaccine, both
the vaccines were found to have mild side effects which could be easily managed.
Formulation, Characterization, and Pharmacokinetic Evaluation of Novel
Glipizide-phospholipid Nano-complexes with Improved Solubility and
Bio-availability
Authors: Rathor Sandeep , Bhatt Dinesh Chandra 
Published: March 2022

Background:
The proposed study was aimed to formulate and evaluate the Glipizide-Phospholipid Nano-complex. Since Glipizide is a poorly soluble drug, its complexation with phospholipids is an ideal approach to improving solubility

Method:
To improve the oral potency of Glipizide, its phospholipid complex was prepared by employing the solvent evaporation method. The formulations were characterized using DSC, FT-IR, PXRD, SEM, TEM, and hot stage microscopy (HSM). Solubility tests of the Glipizide-Phospholipid Nano-complex revealed a significant increase in aqueous solubility compared to Glipizide's physical combination. The oral bioavailability of the Glipizide-Phospholipid Nano-complex was measured by using HPLC in Wistar rats’ plasma. FTIR and PXRD results revealed no significant interaction between the drug and the phospholipid in the formulation. SEM and TEM studies confirmed the morphology of the formulation assuring the conversion of crystalline form into an amorphous structure.

Results:
The Glipizide-Phospholipid Nano-complex had a greater peak plasma concentration (5.2 vs 3.8 g/mL), a larger AUC (26.31 vs 19.55 μgh/L), and a longer T1/2 (2.1 vs 4.1 h) than free Glipizide, indicating that it improved drug dissolution rate.

Conclusion:
The outcomes suggested that a phospholipid complexation is a potential approach to increasing water-insoluble drugs' oral bioavailability.
Влияние скорости деформации на эффект пластификации ультрамелкозернистого сплава Al-Cu-Zr в высокопрочном состоянии
Authors: Садыков Д.И. , Орлова Т.С. , Мурашкин М.Ю. 
Published: March 2022

Исследовалось влияние скорости деформации на эффект пластификации (ЭП) ультрамелкозернистого (УМЗ) сплава Al-1.47Cu-0.34Zr (wt&#37;), структурированного методом интенсивной пластической деформации кручением. Значительное увеличение пластичности (более чем в 2 раза) при сохранении высокого уровня прочности (предел прочности &#126;465 MPa) в УМЗ-сплаве было достигнуто в результате дополнительной деформационно-термической обработки (ДТО), состоящей из низкотемпературного отжига и небольшой дополнительной деформации. Показано, что ЭП после ДТО сохраняется при изменении скорости деформации от 10-4 до 10-3 s-1 и уменьшается вдвое при дальнейшем ее увеличении до 10-2 s-1. Определен коэффициент скоростной чувствительности для УМЗ-сплава Al-1.47Cu-0.34Zr (wt&#37;) в состояниях до и после ДТО. Обсуждаются возможные причины подавления ЭП при высоких скоростях деформации (&ge; 10-2 s-1). Ключевые слова: алюминиевые сплавы, интенсивная пластическая деформация, ультрамелкозернистая структура, прочность, пластичность, скоростная чувствительность.
1. Faptă tipică şi antijuridică împotriva siguranţei circulaţiei pe drumurile publice. Imposibilitatea confiscării vehiculului 2. Faptă tipică şi antijuridică pentru care prin rechizitoriu s-a dispus clasarea. Confiscare. Competenţă şi procedură
Authors: Ștefan Cristian Valentin 
Published: March 2022

1. În ipoteza săvârşirii unei fapte tipice şi antijuridice îndreptate împotriva siguranţei circulaţiei pe drumurile publice, vehiculul condus de subiectul activ nu poate fi confiscat în temeiul art. 112 alin. (1) lit. b) C. pen.
2. Dacă prin rechizitoriu se dispune clasarea pentru o faptă tipică şi antijuridică ce generează o confiscare specială, competenţa de luare a măsurii de siguranţă aparţine judecătorului de cameră preliminară, nu instanţei sesizate cu fapta pentru care prin acelaşi rechizitoriu s-a dispus trimiterea în judecată, iar procedura de urmat este cea specială de confiscare în cazul clasării, nu cea de drept comun, în care se judecă fapta pentru care s-a dispus trimiterea în judecată.
Provocările dreptului penal în faţa noilor mijloace de informare în masă
Authors: Caterini Mario , Șerban Doris Alina , Andone Diana 
Published: March 2022

Articolul prezintă în primul rând modul în care mass-media este înclinată să selecteze informaţii pe criterii pragmatice/comerciale şi nu neapărat folosind ca punct de referinţă relevanţa informaţiei. Rezultatul unei astfel de selecţii ar putea fi o reprezentare distorsionată a realităţii, care ar putea crea griji colective artificiale şi, în consecinţă, ar putea influenţa politica penală şi funcţionarea sistemului penal. A doua parte a articolului analizează tocmai influenţa reprezentării mass-media asupra politicii penale, în special în contextul actual al aşa-numitei „democraţii lichide” dezvoltată în jurul noilor mijloace de informare în masă (în special Internetul). Autorul se concentrează pe riscurile pe care le poate implica această formă de democraţie, în special pe încălcarea potenţială a unor principii fundamentale în sistemele moderne democratice. Concluzia este dedicată culturii dreptului penal, autorul promovând educarea publicului, respectiv o paideia politico-penală, adaptată nevoilor postmoderne democratice şi de masă, care să încerce să urmărească conţinutul ontologic al nivelurilor minime de cunoaştere a cetăţenilor, cum ar fi interiorizarea acelor valori fundamentale care constrâng etosul societăţii civile contemporane.