bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of Large-Scale Implementation of an Electronic Patient-Reported Outcome Remote Monitoring System for Patients on Active Treatment at a Community Cancer Center
Authors: Cherny Nathan I. , Parrinello Christina M. , Kwiatkowsky Lavi , Hunnicutt Jeff , Beck Thaddeus , Schaefer Eric , Thurow Tracy , Kolodziej Michael 
Published: October 2022

PURPOSE: The use of digital symptom monitoring with patient-reported outcomes (PROs) has been shown to improve patient outcomes. The evidence of benefit has been largely derived from research studies. The feasibility of adopting this technology in the real-world setting is unknown. METHODS: We report on the clinical implementation of a proprietary electronic patient-reported outcome (ePRO)–based digital symptom monitoring platform at the Highlands Oncology Group practice, a large community oncology practice. We present here our experience with patient enrollment, engagement, and retention; reasons for discontinued use; proportion of reports generating alerts and containing severe symptoms; and the responses to alerts including nursing telephone consultations and urgent office visits. RESULTS: Over an approximately 17-month period, 923 patients were successfully enrolled. Patients enrolled from June 20, 2020, through November 30, 2021, with follow-up through February 28, 2022. Retention rates at 3, 6, 9, and 12 months were 94%, 88%, 73%, and 67%, respectively, with greater retention at 12 months in patients age 65 years or older. Few patients discontinued use for reasons related to the platform (n = 47; 5%). Of the 25,311 ePRO reports submitted, 49% (n = 12,334) exceeded the predefined alert thresholds and 8% (n = 1,920) included severe symptoms. The nursing team responded within 24 hours by telephone to 31.2% (n = 3,910) of all reports with alerts. Of reports with severe symptoms, 72.7% (n = 1,395) received a call. Only 6.4% (n = 249) of phone calls required an office evaluation within 72 hours of the report. CONCLUSION: This single-center experience indicates that an ePRO-based digital symptom monitoring platform can be effectively implemented at a large scale with a high level of long-term patient engagement. Most reports could be effectively resolved by nurses, and physician intervention was infrequently required.
High-Dose Methotrexate in Patients With Lymphoma: Predictors of a Complicated Course
Authors: O'Donoghue Darragh F. , Truong Huong L. , Finnes Heidi D. , McDonald Jennifer S. , May Heather P. , Ansell Stephen M. , Bennani N. Nora , Habermann Thomas M. , Inwards David J. , Johnston Patrick B. , Khurana Arushi , Lin Yi , Micallef Ivana N. , Nowakowski Grzegorz S. , Paludo Jonas , Porrata Luis F. , Thanarajasingam Gita , Thompson Carrie A. , Villasboas Jose C. , Wang Yucai , Witzig Thomas E. , Leung Nelson 
Published: October 2022

PURPOSE:High-dose methotrexate (HDMTX; > 500 mg/m2) is an important component of lymphoma therapy. Serum MTX monitoring at 48 hours is the standard approach to identify those at increased risk of developing MTX toxicity. Our aim was to characterize the incidence of complications and their association with MTX levels.METHODS:A retrospective review of our institutional electronic medical record was conducted to identify patients with lymphoma who received HDMTX between January 1, 2002, and December 31, 2018. We characterized the incidence of acute kidney injury (AKI), intensive care unit (ICU) admission, length of hospital stay (LOS), and 30-day mortality across 48-hour MTX levels. To establish an association between 48-hour MTX levels and the complications listed, we performed chi-square analysis for dichotomous variables and Kruskal-Wallis for nonparametric data. Receiver operator characteristic curve analysis was performed to identify the MTX level where AKI grade ≥ 2 was more likely. Multivariate logistic regression analysis was performed to identify risk factors for this MTX level.RESULTS:We identified 642 patients with 2,804 cycles of HDMTX. The incidence of AKI was 19.1% with AKI grade ≥ 2 making up 21% of cases. Rates of AKI, ICU admission, and 30-day mortality are associated with elevated 48-hour MTX levels. There was a significant increase in median LOS with elevated MTX levels ( P < .001). Receiver operator characteristic curve analysis for AKI grade ≥ 2 demonstrated a 48-hour MTX level threshold of 1.28 μmol/L. Multivariate logistic regression analysis revealed age, male sex, elevated body surface area, higher MTX dose, monotherapy, and first cycle as independent factors.CONCLUSION:Elevated MTX levels are associated with a significant increased rate of AKI, ICU admission, prolonged LOS, and 30-day mortality. Elevated 48-hour MTX levels, particularly > 1.28 μmol/L, should alert clinicians for complications and to initiate measures to reduce MTX levels.
Geniculate Neuralgia: A Case Report and Systematic Review
Authors: Tatit Rafael Trindade , Raffa Paulo Eduardo Albuquerque Zito , Seba Maria Clara Cardoso , Franceschini Paulo Roberto , de Aguiar Paulo Henrique Pires 
Published: October 2022

BACKGROUND AND IMPORTANCE:
Geniculate neuralgia (GN) is a rare disorder characterized by brief paroxysms of pain felt deeply in the auditory canal, like shock. The diagnosis of GN is essentially clinical and requiring the exclusion of other causes. The aim of this study was to report a case of surgical treatment of the disease and perform a systematic review of surgical treatment options.

CLINICAL PRESENTATION:
A 62-year-old female patient has had severe, sharp pain in her left ear—like an ice pick—for the past 8 months, without any history of trauma or infection. She had triggers for pain, such as talking or swallowing. Imaging investigation showed a vessel touching VIIth and VIIIth nerves, possibly the anterior inferior cerebellar artery. After finding a clinical presentation compatible with GN, treatment with anticonvulsants, gabapentinoids, and opioids was attempted, but without success with such conservative treatments. Therefore, we opted for microvascular decompression and section of the nervus intermedius, which were performed without complications. Neurophysiological assessment was essential to monitor the long tracts and stimulate VIIth and VIIIth nerves to help identify the intermediate nerve. After the procedure, the patient was without pain, and after 12 months of follow-up, she remains without any pain.

CONCLUSION:
Surgical treatment of GN might be beneficial when medical treatment has not worked. Cranial nerves neurophysiological monitoring is not routinely performed, and the identification is based on anatomy. A more comprehensive knowledge of this condition will help in the surgical treatment choice and in achieving better results.
The Impact of Extended Lean Manufacturing Principles on the Economic Efficiency of Industrial Companies
Authors: Gan'kin N. 
Published: October 2022

The main purpose of this study is an analytical proof of the effect of the extended principles of lean manufacturing of economic products on the economic efficiency of industrial companies. To achieve this goal, the following tasks were performed: the tendency to increase the share of value-added operations was investigated, the analysis of existing cost accounting methods was carried out, it was proposed to consider the cost structure depending on the type of operation.
The object of research is modern industrial enterprises using the concept of lean manufacturing and its analogues. The subject of the study is the effect of the extended principles of lean manufacturing in the creation of economic products.
Methods of abstraction and comparative analysis were used to study the impact of the extended principles of lean manufacturing. In addition, methods of analysis and synthesis were used to study the existing methods of cost accounting. The historical method was also used in the work to analyze stable trends in the development of industry.
Based on empirical data, there is a tendency to increase the share of operations that add value to the final product. It was found that non-value-added operations account for 84% of the cost of an economic product, which confirms the need to apply the expanded concept of lean manufacturing in modern realities, as it will significantly reduce this share by eliminating material and especially information losses. As a result of the study of existing methods of cost accounting, it is proposed to consider the cost of any economic product structurally consisting of material and information components for operations that add and do not add value to the final product.
As a result of the conducted research, the influence of the expanded principles lean manufacturing of economic products on the economic efficiency of modern industrial enterprises was analytically proved and the expediency of applying the proposed concept of lean manufacturing was confirmed.
Detour-phased perovskite ultrathin planar lens using direct femtosecond laser writing
Authors: Yang Wenkai , Liu Lige , Dong Dashan , Zhang Xin , Lin Han , Wang Yunkun , Yang Hong , Gao Yunan , Zhong Haizheng , Jia Baohua , Shi Kebin 
Published: October 2022

Perovskite-enabled optical devices have drawn intensive interest and have been considered promising candidates for integrated optoelectronic systems. As one of the important photonic functions, optical phase modulation previously was demonstrated with perovskite substrate and complex refractive index engineering with laser scribing. Here we report on the new scheme of achieving efficient phase modulation by combining detour phase design with 40 nm ultrathin perovskite films composed of nanosized crystalline particles. Phase modulation was realized by binary amplitude patterning, which significantly simplifies the fabrication process. Perovskite nanocrystal films exhibit significantly weak ion migration effects under femtosecond laser writing, resulting in smooth edges along the laser ablated area and high diffractive optical quality. Fabrication of a detour-phased perovskite ultrathin planar lens with a diameter of 150 μm using femtosecond laser scribing was experimentally demonstrated. A high-performance 3D focus was observed, and the fabrication showed a high tolerance with different laser writing powers. Furthermore, the high-quality imaging capability of perovskite ultrathin planar lenses with a suppressed background was also demonstrated.
Improving Syrian refugees’ knowledge of medications and adherence following a randomized control trial assessing the effect of a medication management review service
Authors: Alalawneh Majdoleen , Berardi Alberto , Nuaimi Nabeel , Basheti Iman A. 
Published: October 2022

Background
Syrian refugees living in Jordan have many chronic conditions and use many medications. Pharmacists delivering the Medication Management Review (MMR) service can have a role in improving this growing global refugees’ problem.

Objectives
To assess the effect of the MMR service on adherence to treatment therapy and knowledge of chronic medications for Syrian refugees residing in Jordan.

Methods
This randomized intervention control single-blinded study was conducted in Jordan. Syrian refugees were recruited and randomized into intervention and control groups. Two home visits were delivered to each participant, at baseline and three months later. All participants completed questionnaires regarding adherence and knowledge. As a part of the MMR service, treatment-related problems (TRPs) were recognized for all patients; recommendations to resolve these TRPs were only delivered to intervention group refugees’ physicians; TRPs were corrected. At follow-up, TRPs assessment, adherence and medication knowledge were assessed for all refugee participants.

Results
Participants (n = 106; intervention n = 53, control n = 53) had a number of medications and diagnosed chronic diseases of 5.8 ± 2.1 and 2.97 ± 1.16 per participant respectively. A significant improvement in the adherence and knowledge scores were noted in the intervention (P < 0.001 for both) but not the control group (P = 0.229, P = 0.07 respectively).

Conclusion
The MMR service can significantly improve refugees’ TRPs, adherence to therapy and knowledge of chronic medications. If this approach was extended to the large scale, many refugees in need would be able to access a quality essential health-care service; a step towards achieving universal health coverage.

Trial registration
Registry: ClinicalTrials.gov Identifier: NCT04554810.
Role of interleukin-22 in tuberculosis patients
Authors: Gupta Shruti , Banerjee Mithu , Gauba Kavya , Mitra Prasenjit , Shekhawat Jyoti , Chauhan Nishant , Borana Hemant , Rao Mahadev , Yadav Dharmveer , Sharma Praveen 
Published: October 2022

Abstract

Objectives
Disease progression of tuberculosis (TB) depends on the balance between the microorganism’s virulence and the host defense systems (mainly T cell-mediated immune response). Interleukin-22 (IL-22) helps in cell proliferation and regeneration and provides protection against microbial diseases. The IL-22-producing T cells can migrate into the granulomas during TB infection. However, disparity exists in literature regarding its role. The present study aims to compare serum IL-22 levels and its’ expression in TB patients and healthy controls.

Methods
87 TB patients and 85 healthy subjects were enrolled in the study. Under aseptic conditions, venous blood was withdrawn. Serum IL-22 levels were estimated using enzyme-linked immunosorbent assay, and its gene expression was assessed using SYBR green-based quantitative PCR technology. A statistical analysis was performed using SPSS.

Results
The median (interquartile range) of serum IL-22 levels was significantly lower in TB patients (18.55 (5.08) pg/mL) when compared to controls (49.38 (162.88) pg/mL) (p<0.0001). The IL-22 expression was significantly upregulated with a fold change value of 29.44 in TB patients.

Conclusions
The IL-22 levels were found to be significantly decreased in patients, contradictory to its expression, which is upregulated. It plays a crucial role for the modulation of tissues in response to TB infection.
Conjugacy classes of maximal cyclic subgroups of metacyclic 𝑝-groups
Authors: Bianchi Mariagrazia , Camina Rachel , Lewis Mark L. 
Published: October 2022

Abstract
In this paper, we set

η
⁢

(
G
)

\eta(G)

to be the number of conjugacy classes of maximal cyclic subgroups of a finite group 𝐺.
We compute

η
⁢

(
G
)

\eta(G)

for all metacyclic 𝑝-groups.
We show that if 𝐺 is a metacyclic 𝑝-group of order

p
n

p^{n}

that is not dihedral, generalized quaternion, or semi-dihedral, then

η
⁢

(
G
)

≥

n
-
2

\eta(G)\geq n-2

, and we determine when equality holds.
Co3O4 nanoparticles embedded in electrospun carbon nanofibers as free-standing nanocomposite electrodes as highly sensitive enzyme-free glucose biosensors
Authors: Mohammadpour-Haratbar Ali , Mosallanejad Behrooz , Zare Yasser , Rhee Kyong Yop , Park Soo-Jin 
Published: October 2022

Abstract
Numerous researches have been directed toward enzyme-free biosensors to alleviate the shortcomings encountered with enzymatic biosensors, in particular the intricate enzyme immobilization procedure. Herein, Co3O4/electrospun carbon nanofiber (ECNF) nanocomposites are successfully prepared to be employed as enzyme-free biosensors for diagnosis of glucose. Two parameters including the carbonization time and the amount of Cobalt(ii) acetate tetrahydrate precursor are optimized, which are 5 h and 0.5 g, respectively. The 0.5 Co3O4/ECNF-5 h nanocomposite delivers superior sensitivity (475.72 μA·mM−1·cm−2), broad linear range (2–10 mM), and detection limit (LOD) less than 1 mM (0.82 Mm). In addition, the electrode shows excellent selectivity. The chronoamperometric analysis of 0.5 Co3O4/ECNF-5 h nanocomposite is performed by adding successively glucose analyte and interfering agents to the 0.1 M sodium hydroxide solution. No significant amperometric signal to the interfering agents including uric acid, ascorbic acid, and dopamine is delivered by this electrode, testifying the great selectivity of the electrode toward the diagnosis of target analyte (glucose) in spite of the existence of interfering species. Taking the aforementioned explanations into account, it can be concluded that the Co3O4/ECNF nanocomposite can be an appropriate free-stand electrode for high-performance enzyme-free glucose biosensor.
The effect of surveillance for differentiated thyroid carcinoma in childhood cancer survivors on survival rates: a decision-tree-based analysis
Authors: Heinzel Alexander , Müller Dirk , van Santen Hanneke M , Clement Sarah C , Schneider Arthur B , Verburg Frederik A 
Published: October 2022

Background
Childhood cancer survivors (CCS) who received radiation therapy exposing the thyroid gland are at increased risk of developing differentiated thyroid cancer (DTC). Therefore, the International Guideline Harmonization Group (IGHG) on late effects of childhood cancer therefore recommends surveillance. It is unclear whether surveillance reduces mortality.

Aim
The aim of this study was to compare four strategies for DTC surveillance in CCS with the aim of reducing mortality: Strategy-1, no surveillance; Strategy-2, ultrasound alone; Strategy-3, ultrasound followed by fine-needle biopsy (FNB); Strategy-4, palpation followed by ultrasound and FNB.

Materials and methods
A decision tree was formulated with 10-year thyroid cancer-specific survival as the endpoint, based on data extracted from literature.

Results
It was calculated that 12.6% of CCS will develop DTC. Using Strategy-1, all CCS with DTC would erroneously not be operated upon, but no CCS would have unnecessary surgery. With Strategy-2, all CCS with and 55.6% of CCS without DTC would be operated. Using Strategy-3, 11.1% of CCS with DTC would be correctly operated upon, 11.2% without DTC would be operated upon and 1.5% with DTC would not be operated upon. With Strategy-4, these percentages would be 6.8, 3.9 and 5.8%, respectively. Median 10-year survival rates would be equal across strategies (0.997).

Conclusion
Different surveillance strategies for DTC in CCS all result in the same high DTC survival. Therefore, the indication for surveillance may lie in a reduction of surgery-related morbidity rather than DTC-related mortality. In accordance with the IGHG guidelines, the precise strategy should be decided upon in a process of shared decision-making.
Processes involved in prostaglandin F2alpha autoamplification in heifers
Authors: Domingues Rafael R , Ginther OJ , Gomez-Leon Victor , Nunes da Silva Polyana , Castro Thadeu , Hoppmann August , Wiltbank Milo C 
Published: October 2022

In brief
Endometrial and luteal synthesis of prostaglandin F2alpha (PGF2A) occurs before and during luteolysis and is critical for luteal regression. This study demonstrates that PGF2A stimulates further PGF2A synthesis (autoamplification) apparently from the corpus luteum.

Abstract
Understanding the endocrine profile of prostaglandin F2alpha (PGF2A) autoamplification is fundamental to comprehend luteal and endometrial responses to PGF2A. On day 10 of postovulation (preluteolysis), heifers (n  = 6/group) were treated intrauterine with saline or PGF2A (0.5 mg; hour 0). A third group received flunixin meglumine + PGF (FM+PGF) to prevent endogenous synthesis of PGF2A. Exogenous PGF2A was metabolized at hour 2 as measured by PGF2A metabolite (PGFM). From hours 5 to 48, concentrations of PGFM were greatest in the PGF group, smallest in the FM+PGF, and intermediate in the control suggesting endogenous synthesis of PGF2A only in PGF group. Progesterone (P4) concentrations decreased transiently between hours 0 and 1 in PGF and FM+PGF groups but rebounded to pretreatment concentrations by hours 6 and 4, respectively. No control or FM+PGF heifers underwent luteolysis during the experimental period. Conversely, in the PGF group, one heifer had complete luteolysis (P4 < 1 ng/mL), two heifers had partial luteolysis followed by P4 and CL resurgence by hour 48, and three heifers did not undergo luteolysis. Endogenous PGF2A appears to be of luteal origin due to the lack of pulsatile pattern of PGFM and lack of endometrial upregulation of oxytocin receptor (typical of endometrial synthesis of PGF2A), whereas luteal downregulation of PGF receptor and HPGD indicates a classic luteal response to PGF2A signaling although other specific mechanisms were not investigated. The hypothesis was supported that a single PGF2A treatment simulating the peak of a natural luteolytic pulse and the uteroovarian transport of PGF2A stimulates measurable endogenous PGF2A production.
Peranan Jaksa Sebagai Dominus Liitis Dalam Menuntut Uang Pengganti Akibat Tindak Pidana Korupsi Yang Bersinggungan Dengan Tindak Pidana Perpajakan
Authors: Himawan Himawan , Kristiawanto Kristiawanto , Ismed Mohamad 
Published: October 2022

The criminal procedure law currently still has problems, because there are procedures that must be obeyed and obeyed by law enforcement officials in carrying out and enforcing the law which actually causes law enforcement itself to be useless. This is illustrated when the Prosecutor handles criminal acts of corruption, which in fact also intersects with tax crimes, and cannot carry out law enforcement simultaneously, because legally the current criminal procedure for tax crimes can only be investigated by the Directorate General of Taxes. This is a weakness in the current procedural law, because the redistribution of the findings will take a relatively long time and cost a relatively large amount of money to handle cases. The research method used is a qualitative method with an empirical normative approach. The results of the study state that efforts to overcome weaknesses in the Criminal Procedure Code require a response from law enforcement officials, especially prosecutors to make a breakthrough against the rigidity of the current criminal procedure law by prioritizing the benefits of law enforcement itself.Keywords: Replacement Money; Corruption Crimes; Tax Crime AbstrakHukum acara pidana saat ini masih memiliki permasalahan, karena adanya prosedur yang harus dipatuhi dan ditaati aparatur penegak hukum dalam menjalankan dan menengakkan hukum yang justru menyebabkan penegakan hukum itu sendiri menjadi tidak bermanfaat. Hal ini tergambar pada saat Jaksa menangani tindak pidana korupsi yang ternyata juga bersinggungan dengan tindak pidana perpajakan, dan tidak dapat melakukan penegakan hukumnya secara bersamaan, karena secara hukum acara pidana yang berlaku saat ini terhadap tindak pidana perpajakan hanya dapat disidik oleh Direktorat Jenderal Pajak. Hal inilah menjadi kelemahan dalam hukum acara saat ini, karena dengan dilimpahkannya kembali temuan tersebut akan memerlukan waktu yang relatif lama dan mengeluarkan uang penanganan perkara yang juga relatif tidak sedikit. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan normatif empiris. Hasil penelitian menyatakan bahwa upaya mengatasi kelemahan dalam KUHAP diperlukan respons para aparatur penegak hukum, terutama Jaksa untuk melakukan terobosan terhadap kekakuan hukum acara pidana saat ini dengan mengutamakan kemanfaatan dari penegakan hukum itu sendiri.Kata Kunci: Uang Pengganti; Tindak Pidana Korupsi; Tindak Pidana Perpajakan