bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humoral and cellular immune responses on SARS-CoV-2 vaccines in patients with anti-CD20 therapies: a systematic review and meta-analysis of 1342 patients
Authors: Schietzel Simeon , Anderegg Manuel , Limacher Andreas , Born Alexander , Horn Michael P , Maurer Britta , Hirzel Cedric , Sidler Daniel , Moor Matthias B 
Published: February 2022

BackgroundImmune responses on SARS-CoV-2 vaccination in patients receiving anti-CD20 therapies are impaired but vary considerably. We conducted a systematic review and meta-analysis of the literature on SARS-CoV-2 vaccine induced humoral and cell-mediated immune response in patients previously treated with anti-CD20 antibodies.MethodsWe searched PubMed, Embase, Medrxiv and SSRN using variations of search terms ‘anti-CD20’, ‘vaccine’ and ‘COVID’ and included original studies up to 21 August 2021. We excluded studies with missing data on humoral or cell-mediated immune response, unspecified methodology of response testing, unspecified timeframes between vaccination and blood sampling or low number of participants (≤3). We excluded individual patients with prior COVID-19 or incomplete vaccine courses. Primary endpoints were humoral and cell-mediated immune response rates. Subgroup analyses included time since anti-CD20 therapy, B cell depletion and indication for anti-CD20 therapy. We used random-effects models of proportions.FindingsNinety studies were assessed. Inclusion criteria were met by 23 studies comprising 1342 patients. Overall rate of humoral response was 0.40 (95% CI 0.35 to 0.47). Overall rate of cell-mediated immune responses was 0.71 (95% CI 0.57 to 0.87). A time interval >6 months since last anti-CD20 therapy was associated with higher humoral response rates with 0.63 (95% CI 0.53 to 0.72) versus <6 months 0.2 (95% CI 0.03 to 0.43); p=0<01. Similarly, patients with circulating B cells more frequently showed humoral responses. Anti-CD20-treated kidney transplant recipients showed lower humoral response rates than patients with haematological malignancies or autoimmune disease.InterpretationPatients on anti-CD20 therapies can develop humoral and cell-mediated immune responses after SARS-CoV-2 vaccination, but subgroups such as kidney transplant recipients or those with very recent therapy and depleted B cell are at high risk for non-seroconversion and should be individually assessed for personalised SARS-CoV-2 vaccination strategies. Potential limitations are small patient numbers and heterogeneity of studies included.FundingThis study was funded by Bern University Hospital.
MRI-Based Radiotherapy Planning to Reduce Rectal Dose in Excess of Tolerance
Authors: Schmidt Daniel R. , Bhagwat Mandar , Glazer Daniel I. , Chen Ming-Hui , Moteabbed Maryam , McMahon Elizabeth , Loffredo Marian J. , Tempany Clare M. , D’Amico Anthony V. 
Published: February 2022

Background and Purpose. Chronic rectal toxicity significantly decreases the quality of life for men who receive radiotherapy for prostate cancer. The most significant predictor of rectal toxicity is rectal dose-volume exceeding tolerance. To minimize the volume of rectum in the high dose field, it is essential to accurately define the prostate-rectum interface. This can be challenging to do by computed tomography (CT) imaging alone. The current study was undertaken to formally demonstrate in a clinical trial setting that image-guided intensity-modulated radiation therapy (IG-IMRT) planning using magnetic resonance imaging (MRI) can reduce the volume of rectum exceeding 70 Gy, a validated metric that predicts the risk of late rectal toxicity. Materials and Methods. This prospective single-arm study enrolled 15 men treated with IG-IMRT for localized prostate cancer. All participants received a dedicated 3 Tesla MRI examination of the prostate in addition to a pelvic CT examination for treatment planning. Two volumetric modulated arc therapy (VMAT) plans with a prescription dose of 79.2 Gy were designed using identical constraints based on CT- and MRI-defined consensus volumes. The volume of rectum exposed to 70 Gy or more was compared using the Wilcoxon paired signed rank test. Results. For CT-based treatment plans, the median volume of rectum receiving 70 Gy or more was 9.3 cubic centimeters (cc) (IQR 7.0 to 10.2) compared with 4.9 cc (IQR 4.1 to 7.8) for MRI-based plans. This resulted in a median volume reduction of 2.1 cc (IQR 0.5 to 5.3,

P

< .001). Conclusions. Using MRI to plan prostate IG-IMRT to a dose of 79.2 Gy reduces the volume of rectum receiving radiation dose in excess of tolerance (70 Gy or more) and should be considered in men who are at high risk for late rectal toxicity and are not good candidates for other rectal sparing techniques such as hydrogel spacer. This trial is registered with NCT02470910.
Trichoderma spp. promote root growth and high populations of Meloidogyne enterolobii on tomato crop
Authors: Almeida Sheila F. , Mello Sueli C.M. , Cardoso Ana L.B. , Santos Jansen R.P. , Carneiro Regina M.D.G. 
Published: February 2022

Summary
Meloidogyne enterolobii is an emerging pathogen in Brazil, considered highly destructive to tomato. Due to the lack of cultivars resistant to this nematode, the objective of this work was to evaluate the effect of Trichoderma spp. strains on the promotion of tomato growth and biological control of M. enterolobii populations. The use of eight strains from the CENARGEN collection and three formulated products at a concentration of 1.43 × 106 conidia ml−1 significantly increased the fresh weight of roots compared to control plants inoculated only with nematodes. These Trichoderma strains, except CEN316, also promoted a significant increase in the number of nematodes and in the reproduction factor (RF). With the increase of spore concentration (1 × 108 conidia ml−1) in the second assay, the inoculation of nematode or fungi plus nematode promoted an increase in the fresh weight of roots, except in treatments CEN162, CEN287, UFT 201, and CEN287 + nematodes, which maintained the fresh weight of roots equal to the control without nematodes. None of the spore concentrations (1.43 × 106 and 1 × 108 ml−1) of different Trichoderma spp. strains influenced the plant height (45 and 90 days after nematode inoculation) or the dry plant weight 90 and 110 days after nematode inoculation, respectively. However, there was a positive and significant correlation between RF and fresh root weight, eggs (g root)−1 and total eggs, in the two doses. Furthermore, the Trichoderma spp. strains did not result in control of M. enterolobii under glasshouse conditions after a complete life cycle of the tomato plant: high nematode infection was observed in both doses of the fungi, including in treatments with the commercial formulations.
Hearing God’s Voice
Authors: Harris Tania M. 
Published: February 2022

Abstract
The extra-biblical revelatory experience or, in common parlance, ‘hearing God’s voice’, is frequent among Pentecostals. These experiences involve the possibility of direct contact with God by the Holy Spirit apart from Scripture or human intermediaries. This article draws on the findings of an Australian PhD study to show that the theological approach of Pentecostals in the sample correlates more closely with the Catholic tradition than with the formal theology of their own tradition. This is largely because the Catholics share the Pentecostal position of experiential continuity with the biblical characters rather than the discontinuous framework of the Protestant tradition. Alignment occurs at all facets of the experience, including its content and function, and in the hearing, recognising, and response phases. The study highlights the deficits that have arisen as a result of the misalignment with Protestant theology and offers several helpful correctives for Pentecostal theology and practice.
Tercile Forecasts for Extending the Horizon of Skillful Hydrological Predictions
Authors: Bogner Konrad , Chang Annie Y.-Y. , Bernhard Luzi , Zappa Massimiliano , Monhart Samuel , Spirig Christoph 
Published: February 2022

AbstractMedium to subseasonal hydrological forecasts contain more information relevant to water and environmental management tasks than climatological forecasts. However, extracting this information at the most appropriate level of accuracy and spatiotemporal resolution remains a difficulty. Many studies show that the skill of the extended range forecasts with daily resolution tends toward zero after 7–14 days for small mountainous catchments. Beyond that forecast horizon the application of highly sophisticated pre- and postprocessing methods generally produce limited gains. Consequently, current forecasting techniques cannot effectively represent forecast extremes at extended ranges such as anomalously high and low runoff or soil moisture. To tackle these deficiencies, this study analyzes the value of tercile forecasts for weekly aggregates of runoff and soil moisture forecasts available at a daily resolution for Switzerland. The forecasts are classified into three categories: below, above, and normal conditions, which are derived from long-term simulations and correspond approximately to climatological conditions. To achieve improved reliability and skill of the predicted tercile probabilities, a nonparametric probabilistic classification method has been tested. It is based on Gaussian process (GP), which is attractive in machine learning (ML) applications because of its ability to estimate the predictive uncertainty. The outcome of these postprocessed forecasts was compared to preprocessing methods where the meteorological predictions are statistically corrected before passing to the hydrological model. Our results indicate that tercile forecasts of weekly aggregates produce a suitable skill up to 3 weeks lead time using the preprocessed input and up to 4 weeks lead time using the GP method.
Content and Accessibility of Surgical Critical Care Fellowship Websites in the United States
Authors: Ferre Alexandra C. , Ho Vanessa P. , Lasinski Alaina , Claridge Jeffrey A. 
Published: February 2022

Background Resident physicians are using the Internet to gather information about graduate medical education programs. The content of fellowship websites has been demonstrated to influence applicants’ decisions. The purpose of this study was to evaluate the content of the surgical critical care fellowship (SCCF) program websites. Methods A list of Eastern Association for the Surgery of Trauma (EAST) and American Association for the Surgery of Trauma (AAST) SCCF programs was obtained, and compared to the Accreditation Council for Graduate Medical Education (ACGME) list of accredited programs. The accessibility of each website was assessed through Google®. Content areas were assessed for each SCCF website. Results At the time of this study, 76 SCCF were listed on the EAST website and an additional 14 were supplied by the AAST database. 125 programs were listed in the ACGME database. Of the 76 SCCF listed by EAST, 44 (58%), 32 (42%), and 7 (9%) of SCCF programs had an EAST listing that was 3, 5, or 10 years or more out of date, respectively. Of the 90 SCCF programs listed on EAST or AAST sites, 36 programs (40%) had an inaccurate PD named on their listing. One hundred and nineteen of the 125 (95%) SCCF programs had websites accessible through Google®. Only 25 (20%) programs had a website containing a program description, faculty list, curriculum, and current/past fellows list. Conclusions Many SCCF websites lacked information regarding program specifics. Valuable information for potential applicants was inadequate across SCCF websites.
Evaluating Risk of Noise-Induced Hearing Loss in Otologic Surgery
Authors: Cass Nathan D. , Perkins Elizabeth L. , Bennett Marc L. , Ricketts Todd A. 
Published: February 2022

Objectives: To evaluate risk for noise-induced hearing damage from otologic surgery-related noise exposure, given recent research indicating that noise levels previously believed to be safe and without long-term consequence may result in cochlear synaptopathy with subsequent degeneration of spiral ganglion neurons, degradation of neural transmission in response to suprathreshold acoustic stimuli, and difficulty understanding in background noise. Methods: A prospective observational study of surgeon noise exposure during otologic and neurotologic procedures was performed in a tertiary care center. Surgeon noise exposure was recorded in A- and C-weighted decibel scales (dBA, dBC), including average equivalent (LAeq) and peak (LApeak, LCpeak) levels and noise dose. Results: Sound measurements taken at the ear with continuous recording equipment during cadaveric otologic surgery demonstrated LAeq 80-83 dBA, LApeaks of 105 dBA, LCpeaks of 127 dBC, with noise doses of 0.9% to 6.7%. Sound level measurements during live surgery translabyrinthine approaches yielded lower LAeq of 72 to 74 dBA and lower noise doses compared with temporal bone lab measurements. Raw sound recordings during live surgery demonstrated narrow band, high frequency, high amplitude spikes between 4 and 12 kHz. Conclusion: Noise exposure to surgeons, staff, and patients in the operating room is acceptable per NIOSH recommendations. Temporal bone lab noise exposures are greater, possibly due to poorly maintained drill systems and lack of noise shielding from microscope bulk, yet are also within NIOSH recommended levels.
Determinants of Export Diversification: Evidence from Fractional Logit Estimation Model
Authors: Swathi. M  , Sridharan P. 
Published: February 2022

This article empirically explores the key drivers of export diversification in a large panel of 101 countries consisting of 43 high-income, 47 middle-income, and 11 low-income countries from 1995 to 2019. Considering the fractional nature of the dependent variable (Herfindahl-Hirschman Index), the estimates are obtained using the fractional logit technique with a set of potential determinants of export diversification for all country samples and three sub-samples. The results reveal that human capital accumulation, GDP per capita, population, trade openness, the share of manufactured output to GDP, and FDI are important determinants of export diversification. However, the share of agriculture to GDP and official exchange rate promotes export concentration. Contrary to our all-country estimation, GDP per capita and population act as deterrents to export diversification in low-income countries. In addition, the results show that the value-added in agriculture plays a dominant role in strengthening the export structure of high-income countries. Our findings suggest that policymakers should implement and reform policies targeting human capital accumulation, trade openness, investment, and value addition in the manufacturing sector for diversifying the export structure. JEL Codes: C33, F14, J24, O1
The Rise of Academic Capitalism in Brazil’s Higher Education
Authors: Sigahi Tiago Fonseca Albuquerque Cavalcanti , Saltorato Patrícia 
Published: February 2022

Academic capitalism has become one of the most influential research lines related to higher education. However, its manifestations in developing countries need to be better understood. Changes are taking place in Brazil that can be attributed to a move toward academic capitalism, and concepts provided by the theory of academic capitalism offer a fertile framework for exploring them. Analysis of official documents, regulations, and the actions of a network of participants reveals the mechanisms that reconfigure the boundaries between the public and the private to establish an academic capitalism knowledge/learning regime. Academic capitalism in Brazil took its first steps after the 1968 reform and was consolidated in the 1990s and instrumentalized in the 2000s, and, judging from the associations between the current government and the business sector, it threatens to take an even more aggressive form in the coming years. O capitalismo acadêmico tem se configurado em uma das linhas de pesquisa mais influentes no campo da educação superior. Há, porém, que melhor se entender suas manifestações em países em desenvolvimento. Estão em curso no Brasil mudanças que podem ser atribuídas a um contexto voltado para um capitalismo acadêmico, e os conceitos oferecidos por ela fornecem um fértil framework para explorar tais mudanças. A análise de documentos oficiais, artefatos legais e da atuação de uma rede de atores, são explorados os mecanismos que reconfiguram as fronteiras entre o público e o privado, colocando em movimento um academic capitalism knowledge/learning regime. No Brasil, o capitalismo acadêmico dá seus primeiros passos após a reforma de 1968; ascende e ganha contornos mais intensos a partir da década de 80; consolida-se a partir da década de 90; instrumentaliza-se nos anos 2000 e, com base nas associações entre o atual governo e o setor empresarial, ameaça assumir uma forma ainda mais agressiva nos próximos anos.
Effectiveness of Family-Focused Nurse-led Intervention on Functional Improvement of Patients with Bipolar Disorder at a Tertiary Hospital in South India: A Randomized Controlled Trial
Authors: Kavitha Rajendran Rangasamy , Kamalam Sethuramachandran , Rajkumar Ravi Philip 
Published: February 2022

Background Bipolar affective disorder (BPAD) is a chronic, episodic illness that can create problems and disruptions in the social, occupational, and family functioning of a client. Families are frequently most affected by their bipolar member and have a sense of helplessness to fix bipolar symptoms. The current study aimed to assess the effectiveness of Family-focused Nursing Interventions (FFNI) on functional improvement in the sample of symptomatic bipolar affective disorder clients. Method In this experimental study, 149 patients with BPAD were interviewed along with family members through the consecutive sampling technique from the inpatient ward. Varying block randomization was used to allocate the patients to the control and experimental groups. After obtaining ethical clearance, the study was registered under the Clinical trail registry India (CTRI). Baseline sociodemographic and clinical variables, and the functional levels, were assessed using Longitudinal Interval Follow-up Evaluation-Range of Impaired Functioning Tool and Functional Assessment Short Test. The control group (74) received routine treatment; the experimental group (75) received routine treatment along with FFNI in seven sessions, and posttest was conducted at discharge, one-month, and at two-month follow-up at OPD. The collected data were analyzed using SPSS 20 (IBM Corp. Released 2011. IBM SPSS Statistics for Windows Version 20.0, Armonk, NY: IBM Corp.), independent sample t-test, analysis of variance, and Pearson correlation used. A P-value of less than 0.05 was considered as a statistically significant result. Results At the end of the study, 149 clients completed the treatment and follow-up. Both the groups were comparable at baseline in demography as well as clinical variables. There was significant improvement in the functional level after FFNI. The total score of LIFE-RIFT and the Functional Assessment Short Test score were significantly lower in the experimental group than the control group with P = 0.001. Conclusion The current study concluded that adjuvant to routine treatment FFNI will improve the functional ability of the client along with routine psychiatric treatment for BPAD.
Opioids in acute pain: Towards getting the right balance
Authors: Pattullo Gavin G 
Published: February 2022

Misuse of prescription opioids forced an inevitable response from authorities to intervene with consequences felt by all. In the Australian community one person will die for approximately every 3600 adults prescribed opioids, while in the hospital setting a postoperative patient managed primarily with opioids, as opposed to epidural analgesia, has an additional risk of death as high as between one in 56 to 477. Opioids maintain a valid role in acute pain management when use is reasoned and with full awareness of the harms and how they are to be avoided, such as in those at risk of ongoing use, the opioid naïve, and when opioid-induced ventilatory impairment may occur. Clinicians managing acute pain can focus on assessing pain versus nociception, strategically apply antinociceptive medications and neural blockade when indicated, assess pain with an emphasis on the degree of bothersomeness and functional impairment and, finally, optimise the use of framing and placebo-enhancing communication to minimise reliance on medications.
Characteristics of pre-cluster symptoms in cluster headache: A cross-sectional multicentre study
Authors: Cho Soohyun , Cho Soo-Jin , Lee Mi Ji , Park Jeong Wook , Chu Min Kyung , Moon Heui-Soo , Chung Pil-Wook , Sohn Jong-Hee , Kim Byung-Su , Kim Daeyoung , Kim Jae-Moon , Chung Jae Myun , Oh Kyungmi , Ahn Jin-Young , Gil Young Eun , Chung Chin-Sang , Kim Byung-Kun 
Published: February 2022

Background Contrary to pre-attack symptoms before an individual cluster headache attack, little is known about the pre-cluster symptoms before the onset of cluster bouts. We previously described pre-attack symptoms before cluster headache attacks. The aim of this study was to investigate characteristics of pre-cluster symptoms in patients with episodic cluster headache. Methods In this multicentre study, 184 patients with episodic cluster headache were recruited between October 2018 and December 2020. They were interviewed by investigators and completed a structured questionnaire. To investigate pre-cluster and pre-attack symptoms, we assessed 20 symptoms and signs using the questionnaire. Results The upcoming cluster bout was predictable in 35.3% (n = 65/184) of the patients. When present, pre-cluster symptoms occurred at a median duration of 7 days (interquartile range, 2.3–14 days) before the onset of the cluster bout. Patients with pre-cluster symptoms showed a higher proportion of women, prevalence of pre-attack symptoms and seasonal rhythmicity, frequency of cluster headache attacks per day, and total number of cluster bouts compared to patients without pre-cluster symptoms. In univariable and multivariable logistic regression analyses, female sex was associated with the predictability of pre-cluster symptoms (odds ratio = 2.297, p = 0.016). Conclusions The upcoming cluster bout was predicted in approximately 35% of patients with episodic cluster headache, which may allow for an earlier preventive treatment and help understand the pathophysiology.