bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immature platelet fraction predicts early marrow recovery in febrile neutropenia
Authors: Salvador Christina , Meryk Andreas , Hetzer Benjamin , Bargehr Caroline , Kropshofer Gabriele , Meister Bernhard , Anliker Markus , Crazzolara Roman 
Published: May 2022

Abstract
Purpose: Febrile neutropenia secondary to chemotherapy is one of the most critical complications in cancer treatment. The aim of this study was to determine if an increase in the percentage of immature platelet fraction (IPF%) might predict early neutrophil recovery following cytostatic-dependent aplasia.Methods: A retrospective cohort study compared serial complete blood counts and the level of C-reactive protein (CRP) following induction chemotherapy for Ewing sarcoma. The measurements were taken on a Sysmex XE-2100 instrument. A total of 114 paired samples from 11 children after the first cycle of chemotherapy were analyzed to test if an increase in the IPF% anticipated the CRP peak and recovery of neutrophil count.Results: The nadir of neutrophils, reticulocytes and platelets was reached at 9.7 ± 1.5, 11.0 ± 1.7 and 11.9 ± 0.9 days (mean ± SD), respectively, after start of induction chemotherapy. Still in severe neutropenia, IPF% was the first parameter that significantly increased and anticipated the CRP peak (11.9 ± 1.6 days, mean ± SD). The IPF% continuously increased (maximum = 6.56% ± 2.8%, mean ± SD) and peaked at 12.2 ± 1.4 days (mean ± SD) after commencement of chemotherapy. Compared to neutrophil recovery (14.6 ± 1.4 days, mean ± SD), the IPF% peak was anticipated by 2.4 days (p = 0.0085).Conclusion: IPF% increased significantly at > 48 hours before neutrophil recovery in patients treated with chemotherapy. IPF% is an inexpensive parameter and may be valuable in the management of febrile neutropenia.
Resveratrol attenuates hydrogen peroxide-induced injury of rat ovarian 1 granulosa-lutein cells by resisting oxidative stress via the SIRT1/Nrf2/ARE 2 signaling pathway
Authors: Cai Minghui , Wang Jiao , Sun Haijuan , Guo Qi , Zhang Chi , Yao Haixu , Zhao Chen , Jia Yuhan , Zhu Hui 
Published: May 2022

Abstract
Background: The ovarian granulosa-lutein cells injury and apoptosis induced by oxidative stress may be responsible for female luteal phase deficiency. The antioxidant function of resveratrol has been confirmed, however, its effect on the expression of antioxidant enzymes and regulatory mechanism in ovarian granulosa-lutein cells remains unclear. Results: The H2O2 treatment induced the primary ovarian granulosa-lutein cells injury shown as decreased cell viability, impaired cellular morphology, decreased levels of progesterone and estradiol. The H2O2 treatment also exacerbated cell apoptosis demonstrated as more apoptotic cells stained by Hoechst staining, decreased level of anti-apoptosis protein Bcl-2 and increased level of pro-apoptosis protein Bax. These effects of cell injury and apoptosis induced by H2O2 can be ameliorated by resveratrol. Resveratrol also alleviated oxidative stress induced by H2O2 supported by decreased superoxide anion and cellular total ROS, decreased levels of malondialdehyde and protein carbonyl, increased total antioxidant capacity and biological activity of SOD. Western blot results demonstrated resveratrol reversed the H2O2-induced decrease in levels of antioxidant enzymes containing ARE sequences and activated SIRT1/Nrf2 pathway. Further treatment by siRNA-Nrf2 suggested resveratrol was unable to activate the expression of antioxidant enzymes under a condition of inhibition of Nrf2. Conclusions: In conclusion, these results indicated that resveratrol attenuated oxidative stress to protect H2O2-induced rat ovarian granulosa-lutein cells injury and apoptosis via SIRT1/Nrf2/ARE signaling pathway.
A technique for a more accurate and convenient in coracoclavicular ligament reconstruction of acromioclavicular joint dislocation
Authors: Yu Yun-fei , Yan Song-he , Liu Xiao-fen , Wu Mao 
Published: May 2022

Abstract
Background: The Tight-Rope technique, as a widely accepted strategy for the treatment of acromioclavicular(AC) joint dislocation, is undergoing constant improvement due to the disadvantages of complex operation, long learning curve, reliance on clinical experience and auxiliary equipment, etc. The purpose of this study was to propose a simple and cost-effective improved Tight-Rope technique for reconstructing coracoclavicular(CC) ligament for the treatment of acute AC joint dislocations. Methods: This was a retrospective single-center study conducted between January 2015 and March 2021, involving 23 adult patients with Rockwood Type 3 AC joint dislocations. We performed minimally invasive reconstruction of CC ligament using an improved single-tunnel adjustable Tight-Rope system assisted with a portable Kirchner wire positioning technique and the nice knot. Clinical outcomes of the length of incision, operative time, intraoperative blood loss, post-operative and the number of intraoperative fluoroscopy were assessed using the preoperative and final follow-up Constant Murley system score and postoperative complications such as infection, redislocation, implant loosening, fracture, and hardware pain. Results: 23 patients were followed up from 12 to 18 months. The length of incision was an average of (1.84±1.08) cm. The operative time was an average of (54.61±9.36) min. The intraoperative blood loss was an average of (14.57±9.76) ml. The number of intraoperative fluoroscopy was an average of (11.22±2.68). In these cases, 1 patient had loose internal fixation, 1 patient had postoperative coracoid process fracture, while no complications such as wound infection, internal fixation failure or fracture were found in the other cases. The mean constant score was (37.91 ± 10.26) preparatively, compared to (93.39 ± 6.06) at the final follow-up evaluation. The difference was statistically significant (P < 0.05). Conclusions: This study proposes a simple, accurate and cost-effective technique with a short learning curve for anatomic reconstruction of acute AC joint dislocations. The preliminary clinical and radiographic results of this technique have been very encouraging.
Increased HDL, ApoA1 and decreased Atherogenic Indices after Sleeve Gastrectomy
Authors: Ozener Onur , Mayir Burhan , Yilmaz Esin , Yilmaz Necat 
Published: May 2022

Abstract
PurposeOxidative stress (OS) and dysregulation of lipid metabolism are thought to be pathophysiological mechanisms linking high-density lipoprotein cholesterol (HDL-C) dysfunction to obesity. The aim of this study is to determine the dynamic changes in HDL-C functionality and possible changes in atherogenic risk indices in patients after sleeve gastrectomy (SG).MethodsThis is a prospective study in which 30 patients who underwent SG for morbid obesity were evaluated preoperatively (preop) and postoperatively (postop). Preoperative and postoperative atherogenic risk indices were calculated, and serum paraoxonase-1 (PON-1) and apolipoprotein-A1 (Apo-A1) and platelet activating factor acetyl hydrolase (PAF-AH) levels were measured to evaluate the change in HDL-C function. In addition, the amount of oxidized low-density lipoprotein (Ox-LDL), which is the indicator of OS, was measured.ResultsWe observed improvements in atherogenic risk indices after SG and dynamically measurements of HDL-C functionality. Most importantly, statistically significant increases in HDL-C and HDL-C-associated Apo-A1 levels were seen as early as 6 months after surgery. In addition, triglycerides (TGs), PON-1 levels and also atherogenic risk indices decreased statistically significantly within 6 months. While there was no statistically significant change in blood total cholesterol (TC) and Ox-LDL levels, similarly, PAF-AH levels in HDL-C structure did not show any statistically significant change after SG. ConclusionTo the best of our knowledge, there is no study in the literature that examines dynamic changes in atherogenic risk indices, PON-1, Apo-A1 and Ox-LDL parameters with SG. Presently, this preliminary study supports the role of SG in the treatment of obesity-related HDL-C dysfunctionality.
Comparative Study of Single Biological Neuron model with a proposed Artificial Neuron model
Authors: Panda Sashmita 
Published: May 2022

Abstract
In an attempt to propose a closer model of a single biological neuron, various artificial neural models have been reported in the literature. Many articles are available on artificial neurons which tried to mimic a single biological neuron but those models are unable to produce the spiking patterns of a real biological neuron. Hence there is further scope to develop and investigate alternative improved spiking neural models which will better represent the activities of a biological neuron. With this motivation, much modification is done in an artificial neuron model in order to generate the spike patterns that a real biological neuron produces. The proposed modified single artificial neuron model exhibits the activities of a biological neuron. Modeling of a spiking bio-neuron is still an important exercise in view of possible applications of the underlying features in the areas of neuromorphic engineering, cognitive radio, and spiking neural networks
The use of hydromulching increases yield and quality of artichoke (Cynara cardunculus var. scolymus) by improving soil physicochemical and biological properties
Authors: Romero-Muñoz Miriam , Gálvez Amparo , Amor Francisco del , Albacete Alfonso , López-Marín Josefa 
Published: May 2022

Abstract
We hypothesized that organic liquid mulching formulations called hydromulching can be used in sustainable agricultural production through its direct influence on physicochemical and biological soil properties to improve crop yield and quality. To test this hypothesis, artichoke plants were grown using three hydromulching treatments, rice hulls (RH), wheat straw (WS), and mushroom substrate (MS), and two control treatments, soil covered with polyethylene (PE) and bare soil (BS). Hydromulched soils showed an increase in organic matter, organic carbon, moisture, and mineral contents of K+, P, Cu2+, Mn2+, and Zn2+, particularly in the MS-covered soil. Importantly, plant water relationships were superior in all mulching treatments giving rise to the improvement of crop yield and the most important physical quality parameters in artichoke, namely color, firmness, and size. Furthermore, the content of some important nutrient elements in artichoke (K+ and N) were greater in RH and MS treatments, while sugar concentrations were higher in BS compared to the other treatments. Our data demonstrate that hydromulching is a sustainable alternative to plastic mulching that regulates plant hydric status and soil moisture and fertility, thus improving yield and physical quality characteristics of artichoke heads, and maintaining their chemical and nutritional quality over bare soil.
Response Surface Mesh with the Outer Input Method
Authors: Duarte Francisco Daniel Filip 
Published: May 2022

Abstract
Artificial intelligence in general and optimization tasks applied to the design ofvery efficient structures rely on response surfaces to forecast the output of functions, and are vitalpart of these methodologies. Yet they have important limitations, since greater precisions requiregreater data sets, thus, training or updating larger response surfaces become computationallyexpensive or unfeasible. This has been an important bottle neck limitation to achieve morepromising results, rendering many optimization and AI tasks with a low performance.To solve this challenge, a new methodology created to segment response surfaces is herebypresented. Differently than other similar methodologies, this algorithm named outer input methodhas a very simple and robust operation, generating a mesh of near isopopulated partitions ofinputs which share similitude. The great advantage it offers is that it can be applied to any dataset with any type of distribution, such as random, Cartesian, or clustered, for domains with anynumber of coordinates, significantly simplifying any metamodel with a mesh ensemble.This study demonstrates how one of the most known and precise metamodel denominatedKriging, yet with expensive computation costs, can be significantly simplified with a responsesurface mesh, increasing training speed up to 567 times, while using a quad-core parallelprocessing. Since individual mesh elements can be parallelized or updated individually, its fasteroperational speed has its speed increased.
Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction
Authors: Kamath Mohan S. , Kamath Vandana , Chacko Mary Purna 
Published: May 2022

Abstract:
In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal
screening tool, it has gained recognition for its sensitivity and specificity in the detection of common
aneuploidies. This review mainly focuses on the emerging role of NIPT in pregnancies following
assisted reproductive technology (ART) in the light of current evidence and recommendations. It also
deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies,
with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded
as the Achilles’ heel of most pre-natal screening platforms. Future directions for exploration towards
improving the performance and extending the scope of NIPT are also addressed.
Outpatient Use of Electrical Impedance Tomography in Patients with
Chronic Obstructive Pulmonary Disease: A Scoping Review
Authors: Benavides-Cordoba Vicente , Medina Diana Quintero , Luna Esther Cecilia Wilches 
Published: May 2022

Objective:
Electrical Impedance Tomography (EIT) has emerged as a non-invasive, radi-ation-free imaging modality that allows monitoring at the patient's bedside, providing real-time in-formation on the regional distribution of pulmonary ventilation. Although there has been increasing research on EIT in Intensive Care Units (ICUs), few studies use this tool in patients with spontane-ous breathing. The objective is to describe the current evidence regarding the outpatient use of EIT in patients with chronic obstructive pulmonary disease (COPD).

Methods:
A scoping review was performed. An extensive search was conducted in seven health-based databases, Scopus, Medline, OVID, Scielo, PEDro, EBSCO, and VHL search portal. In this scoping review, the checklist recommended by PRISMA was used. To assess the quality of the studies, the BEME protocol of "questions to ask about the evidence of an investigation or evalua-tion" was used.

Results:
In this scoping review, 7 studies published between 2009 and 2019 related to the outpatient use of EIT in COPD patients were identified. The evidence reviewed allowed us to identify that the frequent use is related to the evaluation of the distribution of ventilation, the evaluation of regional respiratory mechanics, and the degree of pre- and post-bronchodilator obstruction.

Conclusion:
EIT is used on an outpatient basis in patients with COPD as an evaluation tool that complements the information regarding the clinical results of pulmonary function tests, improving the monitoring of the course of the disease in real-time, non-invasively, and without ionizing radiation.
Predictors of Early Pregnancy Fatigue among Iranian Women during the
COVID-19 Pandemic: A Cross Sectional Study
Authors: Veisy Afsaneh , Charandabi Sakineh Mohammad Alizadeh , Abbas-Alizadeh Shamci , Ghaderi Fariba , Haghighi Mahmonir , Mirghafourvand Mojgan 
Published: May 2022

Background:
Fatigue is a common problem in pregnancy and is associated with negative
outcomes.

Objective:
This study aimed to determine the predictors of fatigue in pregnant women.

Methods:
This cross-sectional study was conducted on 150 pregnant women with a gestational age
of 12-18 weeks visiting the healthcare centers in Mahabad-Iran, 2021. Fatigue was assessed via the
modified Multidimensional Assessment of Fatigue (MAF) checklist, depression via the Edinburgh
Postnatal Depression Scale (EPDS), stress and anxiety via Depression, Anxiety and Stress Scale-21
(DASS-21), well-being via WHO-5, and positive and negative affect via International Positive and
Negative Affect Schedule-Short Form (I-PANAS-SF). The general linear model was used to estimate
the degree of the effect of each independent variable (sociodemographic characteristics, depression,
stress, anxiety, positive and negative affect, and well-being) on the dependent variable
(early pregnancy fatigue).

Results:
The mean (SD) fatigue score was 21.91 (7.07), within the 0-50 possible range. The majority
of pregnant women (87.3%) suffered from fatigue. Based on the Pearson or Spearman correlation
analysis, a significant correlation was observed between fatigue and depression (r= 0.334, P<0.001),
anxiety (r= 0.327, P<0.001), stress (r=0.329, P< 0.001), well-being (r= -0.279, P<0.001), and negative
affect (r= 0.308, P<0.001). Based on the adjusted general linear model, the education, stress and
negative affect variables were predictors of fatigue.

Conclusion:
The education, stress and negative affect predict fatigue in pregnant women, and their
identification contributes to the designation of interventions to mitigate fatigue in this group. More
studies are required to identify the causes of fatigue during pregnancy.
Integrative Medicine in the Treatment of COVID-19: An Indian Perspective
Authors: Namdeo Ajay G. , Varghese Ryan , Kapase Yogita , Kumbhar Pradnya 
Published: May 2022

Background:
Over recent years, evidence-based modern medicine has overshadowed the use and efficacy of natural and traditional medicines. However, in the wake of the pandemic, the interest in the quest for therapeutic resources linked to traditional, complementary, and integrative medicine has substantially increased. This has further facilitated the research and development of potential therapeutic crude drugs or their formulations in the management of COVID-19 and the symptoms associated with the latter. This article attempts to provide a comprehensive review of the various traditional medicines used as integrative medicines in alleviating symptoms attributed to the COVID-19 infection.

Methods:
The literature was thoroughly browsed for recent research articles, systematic reviews, case studies, and review articles on ScienceDirect, PubMed, and Google Scholar using keywords like complementary medicine, alternative medicine, and holistic approach to enlist a few. Subsequently, they were thoroughly screened to include only recent studies and evidence. Additionally, the official guidelines published by the Government and other regulatory bodies were also sought to be included in the article.

Study Design:
The review article follows the narrative literature review method. However, the primary data was skimmed for relevance and only recent shreds of evidence, pertinent to the review were included.

Results:
The review elucidated the pharmacological activity of various treatment regimens in different systems of medicine, with available supportive clinical evidence. Additionally, it also underscored the importance of holistic health interventions, and how these traditional and integrative systems of medicine cater to the same.

Conclusions:
The recent evidence presents a broad-spectrum effect of these therapeutic interventions, primarily in the fields of mental health, mild to moderate, and even severe forms of the infection, employing various pharmacological pathways. These studies primarily include studies and statistics pertaining to the SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) but may include supporting evidence from other respiratory viruses. This information may prove imperative in guiding new research, and also to design and support an integrative treatment regimen. Conclusively, any suspicion pertaining to the COVID-19 infection should be sought by following the protocols recommended by the concerned health authorities of the respective region/country.
Therapeutic Evaluation of Safoof-e-Pattharphori with Sharbat BazooriMoatadil in Patients of Renal Stone
Authors: Rehman Fazlur , Ansari Mohammad Shakeel , Nizam Rabia , Hamiduddin Hamiduddin 
Published: May 2022

Background and Objective:
Stone formation is one of the common urological disorders;the Unani system of medicine provides an immense treasure of single and compound formulations for the safe management of urolithiasis. The objective of the study is to evaluate the effect of Unani Medicine formulation Safoof-e-Pattharphori with Sharbat Bazoori Moatadil in patients of Hasat-ul-Kulya (Renal stone) as conservative treatment.

Method:
This was a single-arm; open-labeled, pre and post without control clinical trial entailing 30 diagnosed cases of Hasat-ul-Kulya (Renal Stone)up to 10mm diagnosed by USG, belonging to 18-65 years of age, either sex and who had agreed to sign the informed consent form and follow up the protocol. The patients were exposed with Unani formulation i.e., 5gm of Safoof-e-Pattharphori orally once daily with 50ml of Sharbat Bazoori Moatadil up to 45 days with three follow-ups. The assessments of subjective parameters were done at every 15th day of follow-up by using an arbitrary scale. The assessments of objective parameters were carried out before and after the trial. The results were analyzed statistically using Wilcoxon signed-rank test, Student’s paired t-test (two-tailed), and proportion test.

Results:
The subjective parameters like pain in the abdomen showed significant relief with (p < 0.001). Objective parameters like USG abdomen showed significant results (p <0.001). The size of the stone showed a statistically significant reduction (p <0.001). No significant adverse changes were observed in safety parameters during and after the trial.

Conclusion:
It can be concluded that the Unani formulation Safoof-e-Pattharphori with Sharbat bazoori moatadil is safe and effective in renal stone treatment.
Clinical Trials Registry of India
An impact evaluation of an education bundle for patients at risk of developing venous thromboembolism
Authors: Boyer Nicole , Skinner Robert , Breck Andrew 
Published: May 2022

Aim:
Among hospitalized patients, venous thromboembolism (VTE) is a preventable cause of morbidity and mortality. This study analyzed the effects of a large-scale adoption of a prompt response and education protocol to increase VTE prophylaxis adherence in the USA.
Methods:
A Markov model was developed that simulates outcomes and costs of delivering a VTE education bundle versus not, to hospitalized at-risk patients.
Results:
The education bundle could avert more than 134,000 VTEs, 552,000 hospital days and 19,000 deaths over 5 years. Patients could save 13 million hours in work absenteeism and travel time, valued at US$237 million. Total societal savings could amount to US$2.8 billion. In scenario analyses with assumed lower-effectiveness estimates, the bundle averts 16,000 VTEs, 67,000 hospital days and 2000 deaths.
Conclusion:
A nationwide rollout of an education bundle to reduce missed doses of prescribed prophylaxis could improve quality of care, resulting in a decline in VTEs and mortality.