bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical-Blocks―A Platform for Exploration, Management, Analysis, and Sharing of Data in Biomedical Research: System Development and Integration Results
Authors: Valenzuela Waldo , Balsiger Fabian , Wiest Roland , Scheidegger Olivier 
Published: March 2022

Background
Biomedical research requires health care institutions to provide sensitive clinical data to leverage data science and artificial intelligence technologies. However, providing researchers access to health care data in a simple and secure manner proves to be challenging for health care institutions.

Objective
This study aims to introduce and describe Medical-Blocks, a platform for exploration, management, analysis, and sharing of data in biomedical research.

Methods
The specification requirements for Medical-Blocks included connection to data sources of health care institutions with an interface for data exploration, management of data in an internal file storage system, data analysis through visualization and classification of data, and data sharing via a file hosting service for collaboration. Medical-Blocks should be simple to use via a web-based user interface and extensible with new functionalities by a modular design via microservices (blocks). The scalability of the platform should be ensured through containerization. Security and legal regulations were considered during development.

Results
Medical-Blocks is a web application that runs in the cloud or as a local instance at a health care institution. Local instances of Medical-Blocks access data sources such as electronic health records and picture archiving and communication system at health care institutions. Researchers and clinicians can explore, manage, and analyze the available data through Medical-Blocks. Data analysis involves the classification of data for metadata extraction and the formation of cohorts. In collaborations, metadata (eg, the number of patients per cohort) or the data alone can be shared through Medical-Blocks locally or via a cloud instance with other researchers and clinicians.

Conclusions
Medical-Blocks facilitates biomedical research by providing a centralized platform to interact with medical data in collaborative research projects. Access to and management of medical data are simplified. Data can be swiftly analyzed to form cohorts for research and be shared among researchers. The modularity of Medical-Blocks makes the platform feasible for biomedical research where heterogeneous medical data are required.
A Data-Driven Algorithm to Recommend Initial Clinical Workup for Outpatient Specialty Referral: Algorithm Development and Validation Using Electronic Health Record Data and Expert Surveys (Preprint)
Authors: Ip Wui , Prahalad Priya , Palma Jonathan , Chen Jonathan H 
Published: March 2022

BACKGROUND

Millions of people have limited access to specialty care. The problem is exacerbated by ineffective specialty visits due to incomplete prereferral workup, leading to delays in diagnosis and treatment. Existing processes to guide prereferral diagnostic workup are labor-intensive (ie, building a consensus guideline between primary care doctors and specialists) and require the availability of the specialists (ie, electronic consultation).

OBJECTIVE

Using pediatric endocrinology as an example, we develop a recommender algorithm to anticipate patients’ initial workup needs at the time of specialty referral and compare it to a reference benchmark using the most common workup orders. We also evaluate the clinical appropriateness of the algorithm recommendations.

METHODS

Electronic health record data were extracted from 3424 pediatric patients with new outpatient endocrinology referrals at an academic institution from 2015 to 2020. Using item co-occurrence statistics, we predicted the initial workup orders that would be entered by specialists and assessed the recommender’s performance in a holdout data set based on what the specialists actually ordered. We surveyed endocrinologists to assess the clinical appropriateness of the predicted orders and to understand the initial workup process.

RESULTS

Specialists (n=12) indicated that &lt;50% of new patient referrals arrive with complete initial workup for common referral reasons. The algorithm achieved an area under the receiver operating characteristic curve of 0.95 (95% CI 0.95-0.96). Compared to a reference benchmark using the most common orders, precision and recall improved from 37% to 48% (<i>P</i>&lt;.001) and from 27% to 39% (<i>P</i>&lt;.001) for the top 4 recommendations, respectively. The top 4 recommendations generated for common referral conditions (abnormal thyroid studies, obesity, amenorrhea) were considered clinically appropriate the majority of the time by specialists surveyed and practice guidelines reviewed.

CONCLUSIONS

An item association–based recommender algorithm can predict appropriate specialists’ workup orders with high discriminatory accuracy. This could support future clinical decision support tools to increase effectiveness and access to specialty referrals. Our study demonstrates important first steps toward a data-driven paradigm for outpatient specialty consultation with a tier of automated recommendations that proactively enable initial workup that would otherwise be delayed by awaiting an in-person visit.
Streamlined versus traditional consent for low-risk comparative effectiveness trials: a randomized experimental study to measure patients' and public attitudes
Authors: Kass Nancy E , Faden Ruth R , Morain Stephanie R , Hallez Kristina , Stametz Rebecca A , Milo Amanda R , Clarke Deserae 
Published: March 2022

Aim:
Streamlining consent for low-risk comparative effectiveness research (CER) could facilitate research, while safeguarding patients' rights.
Materials & methods:
2618 adults were randomized to one of seven consent approaches (six streamlined and one traditional) for a hypothetical, low-risk CER study. A survey measured understanding, voluntariness, and feelings of respect.
Results:
Participants in all arms had a high understanding of the trial and positive attitudes toward the consent interaction. Highest satisfaction was with a streamlined approach showing a video before the medical appointment. Participants in streamlined were more likely to mistakenly think a signature was required.
Conclusion:
Streamlined consent was no less acceptable than traditional, signed consent. Streamlined and traditional approaches achieved similar levels of understanding, voluntariness and a feeling that the doctor–patient interaction was respectful.
Contra-colonialidades nos coletivos juvenis
Authors: Alves Fontes Jean Vitor , Akemi Takeiti Beatriz , Lopes Correia Ricardo 
Published: March 2022

Este artigo trata de um recorte de uma pesquisa participante e tem como objetivo discutir pistas contra-coloniais nas ações, movimentos e modos de organização de um coletivo cultural de jovens urbanos periféricos da Zona Oeste do Rio de Janeiro. Os saberes compartilhados e discutidos aqui partiram de uma produção coletiva e horizontal, inspirada na Investigação Ação-Participante de Orlando Fals Borda. Esta escolha metodológica parte de um compromisso ético e social com os participantes e suas pautas sociopolíticas. O desenvolvimento do artigo perpassa pelos modos de organização e atuação do coletivo Cultura Zona Oeste no território, pelas suas produções artístico culturais e as dimensões políticas nelas pautadas, articulando, desta forma, teorias e conceitos que nos possibilitam refletir as ações contra-coloniais presentes na movimentação do coletivo pelo território.
Protein Content of Tempe from Pumpkin Seeds (Cucurbita moschata) and Its Use as a Learning Media
Authors: Hasrina Hasrina , Nurdin Musdalifah 
Published: March 2022

Pumpkin seeds (Cucurbita moschata) in daily life is used only limited to pumpkin seed snack, whereas pumpkin seeds can be processed in various forms. One of them is pumpkin seed tempeh. Tempeh is a traditional fermented food rhizopus sp. made by fermentation and can be used as a food source that has economic value which has high protein. This study aims to determine the protein levels in pumpkin seed tempeh and its use as a learning media. The research type is an explorative descriptive research. Tempe pumpkin seeds were analyzed for protein levels by using micro Kjedhal analysis through three stages, namely destruction, distillation and titration as many as three repetitions. The results show the average protein level of pumpkin seed tempeh is 24.66%. Based on the results of validation tests by a team of experts in content, design and media as well as 20 students, the results of the study are very worthy to be used as a learning media in the form of posters with a feasibility percentage of 81.49%.
Обоснование применения модели смешанного обучения в преподавании физической культуры в школе
Authors: Голикова Елена , Панкратович Татьяна , Нефедова Виктория 
Published: March 2022

Цель исследования: обосновать эффективность модели смешанного обучения в преподавании физической культуры в школе.
Методика и организация исследования. В рамках научной работы проведен анализ тенденции перехода к цифровому образованию и возможности включения информационно-телекоммуникационных ресурсов в программу по физической культуре. В первой части исследования проведен опрос учителей физической культуры, изучены слабые стороны современных электронно-коммуникативных платформ, предлагаемых для внедрения в образовательную практику. Вторая часть посвящена разработке тематического плана по физической культуре, отражающего как практико-ориентированную направленность дисциплины, так и комплект информационных ресурсов. Тематический план транслирован в образовательные организации Оренбургской области с использованием модели смешанного обучения «перевернутый класс».
Результаты исследования и выводы. Результативность предложенного материала отслеживалась во фронтальном эксперименте по разработанным показателям: знаниевый компонент, самостоятельность и активность обучающихся. Результаты в основной группе увеличились на (14% и 30%), тогда как в контрольной группе повысились на (4% и 4%).
Yield, quality and plant nutrient contents of lettuce under different deficit irrigation conditions
Authors: Demir Halil , Kaman Harun , Sönmez İlker , Mohamoud Salahudin Saed , Polat Ersin , Üçok Zafer 
Published: March 2022

This research was carried out in two separate periods (spring and autumn) in 2018 to reveal the lettuce response of yield, some quality, and plant nutrient content under different water stress conditions. In the study, the effects of different irrigation levels applied with traditional deficit irrigation (TI) and partial rootzone drying (PRD) techniques on lettuce growing were investigated. Lettuce (Lactuca sativa var. crispa cv. ‘Campania’) was used as plant material. There were traditional farmers’ method of irrigation (TF), 125% traditional irrigation (TI-125), 100% traditional irrigation (TI-100), 75% traditional irrigation (TI-75), 50% traditional irrigation (TI-50), 125% partial root-zone drying technique (PRD-125), 100% partial root-zone drying technique (PRD-100), 75% partial root-zone drying technique (PRD-75), 50% partial root-zone drying (PRD-50) technique treatments. According to the results of the research, it was determined that different water stress applications were effective on the criteria examined in lettuce. The highest total and marketable yield values were obtained from the TF application, the second-highest values from the TI-125 application, and the lowest yield from the PRD-50 in the autumn period. In the spring season, the lowest yield was obtained from TI-50 and PRD-50 applications. Based on the treatments, the yield values were decreased and changes were experienced with the increase of the water stress in other examined criteria.
Investigating the altitude impact on the eco-phytochemical parameters of Ziziphora clinopodioides and Sophora alopecuroides in the different regions of northern Iran
Authors: Khatami Moghaddam Mohammadreza , Fallah Hormoz , Niknejad Yosoof , Dastan Salman 
Published: March 2022

Various environmental factors such as altitude significantly affect the pharmacological and chemical properties of the plant. Here, the effect of three different altitudes of 1800 m (Rineh region), 2300 m (Polur region) and 2800 m (Lar region) above sea level on growth traits, yield and compositions of essential oil of two medicinal plants (Ziziphora clinopodioides Lam and Sophora alopecuroides L.) during two successive years (2018 and 2019) was investigated. The results showed that increasing the altitude from 1800 to 2800 m above sea level increased the morphological traits such as height, side branch number, root length and root volume, however, decreased the dry and fresh weight of both Ziziphora and Sophora plants. In Sophora plant, increasing the altitude enhanced the yield of essential oil and the highest yield of essential oil was obtained in Lar region. However, in Ziziphora, elevating the altitude from 1800 to 2300 m decreased the yield of essential oil, but further increase to 2800 m significantly increased the yield of essential oil. In Ziziphora, the highest amount of sophoramine, sophoridane and sophocarpine compounds was obtained at 1800 m, while the highest rates of adenocarpine, vinylphenol and matridin was obtained at 2800 m. For Sophora, the highest amount of sophoramine and vinylphenol was obtained at 2300 m, while sophocarpine showed the highest rate at 2800 m. Therefore, altitude is one of the important parameters of natural ecosystems that effectively change the quantitative and qualitative parameters of medicinal plants.
Examination of morphological and molecular changes in tomato (Solanum lycopersicum L.) seedlings with the application of tebuconazole
Authors: Öztürk Halil İbrahim , Bulut Hüseyin , Dursun Atilla 
Published: March 2022

This study aims to determine the effects of tebuconazole substance used at different doses on the quality of tomato seedlings, retrotransposon mobility caused by this substance in the plants and its genotoxic effects and to determine the optimum dose to be used in practice in seedling production. Tebuconazole applied different concentrations (25, 50, 75, 100, 125 and 150 ppm) were tested. According to the study results, the seedling length and stem length significantly according to the applied doses. The study found out that the stem, leaf and root dry matter contents and leaf chlorophyll content (SPAD values) also statistically significantly changed based on the applied doses. According to the data obtained, the lowest seedling length (12.68 cm) and stem length (4.75 cm) were obtained from a dose of 150 ppm. The highest dry matter content in seedlings was obtained at a dose of 50 ppm in stem (22%) and at 0 ppm (control) in leaves (25.01%) and root. In the study, the highest leaf chlorophyll content (SPAD values) was determined at doses of 150 ppm, 125 ppm and 75 ppm, respectively. This study revealed that various doses of tebuconazole had a positive effect on controlling the height of tomato seedlings and specific quality characteristics of seedlings. In addition, molecular analyzes showed that polymorphism ratios in plants that were applied the substance at different doses varied between 4.70% and 38.09% and the GTS (genomic template stability) value varied between 61.91% and 95.30%. Analyses indicated that the polymorphism ratio increased depending on the increase in dose whereas the GTS value decreased.
X-ray tube operators can be exposed to equal or higher scattered radiation doses to the hand as cassette holders during diagnostic radiographic procedures of the equine vertebral column and limbs
Authors: Belotta Alexandra F. , Mayer Monique N. , Waldner Cheryl L. , Sidhu Narinder P. , Robinson Kate A. , Carmalt James L. , Freitas Fernando P. , Koehncke Niels K. 
Published: March 2022

Abstract

OBJECTIVE
The objectives of this study were to investigate scattered radiation doses to the hands of equine workers holding the cassette and the x-ray tube by hand, for both limb and vertebral column studies, and to compare the scattered radiation attenuation of lead with radiation protection lead-free gloves. Radiation doses to the hands of the cassette holder in the primary beam were also investigated.

SAMPLE
A whole-body horse cadaver.

PROCEDURES
A portable x-ray unit was used to simulate 6 radiographic study types in the horse cadaver. Doses were measured with no shielding and, for cassette holders, with the ion chamber enclosed in a lead glove and a lead-free glove. Thirty exposures were performed for each study view and condition (n = 1,920).

RESULTS
Mean scattered doses to x-ray unit operators were higher than doses to cassette holders for ungula (hoof), thoracic vertebrae, and lumbar vertebrae studies, whereas doses to cassette holders were higher than doses to x-ray tube operators for studies of the metacarpophalangeal joint (fetlock) and tarsus (hock). Doses did not differ for the stifle joint. Mean percentage decrease in scattered radiation dose was 99.58% with lead gloves and 98.9% with lead-free gloves.

CLINICAL RELEVANCE
X-ray tube operators can be exposed to equal or higher scattered radiation doses to the hand as cassette holders. Lead-free hand shielding should only be considered as an alternative to lead gloves if their lighter weight increases frequency of use by workers.
MicroRNAs are differentially expressed in the serum and renal tissues of cats with experimentally induced chronic kidney disease: a preliminary study
Authors: Grimes Janet A. , Lourenço Bianca N. , Coleman Amanda E. , Rissi Daniel R. , Schmiedt Chad W. 
Published: March 2022

Abstract

OBJECTIVE
To identify differentially expressed microRNA in the serum and renal tissues of cats with experimentally induced chronic kidney disease (CKD).

SAMPLE
Banked renal tissues and serum from 4 cats.

PROCEDURES
Cats previously underwent 90-minute unilateral ischemia with delayed contralateral nephrectomy 3 months after ischemia. Tissues were collected from the contralateral kidney at the time of nephrectomy and from the ischemic kidney 6 months after nephrectomy (study end). Serum was collected prior to ischemia (baseline serum) and at study end (end point serum). Total RNA was isolated from tissues and serum, and microRNA sequencing was performed with differential expression analysis between the contralateral and ischemic kidney and baseline and end point serum.

RESULTS
20 microRNAs were differentially expressed between ischemic and contralateral kidneys, and 52 microRNAs were differentially expressed between end point and baseline serum. Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum. Predicted target search for these microRNA revealed multiple genes previously shown to be involved in the pathogenesis of feline CKD, including hypoxia-inducible factor-1α, transforming growth factor-β, hepatocyte growth factor, fibronectin, and vascular endothelial growth factor A.

CLINICAL RELEVANCE
MicroRNAs were differentially expressed after CKD induction in this preliminary study. Regulation of renal fibrosis in feline CKD may occur through microRNA regulation of mRNAs of pro- and anti-fibrotic genes.
How to create an engagement-friendly environment in reward-based crowdfunding?
Authors: Bielicki Marcin , Rydzewski Rafał 
Published: March 2022

Abstract
Crowdfunding appears to be an innovative way of fundraising various projects. Although it is a relatively new and unique way of financing, competition for potential backers increases every year. While recent works have explored the role of engagement and involvement in crowdfunding, there is still a lack of understanding of how creators can stimulate backers’ activity. Therefore the aim of this paper is to identify and classify the methods used for crowdfunding by the top creators to boost and maintain backer engagement. Drawing from the Theoretical Model of Customer Engagement and Theory of Intrinsically Motivating Instruction, we propose a theoretical model that is backer engagement-based. It presents the unique role of involvement and participation in engagement and its interrelationship with value and community involvement. We investigate the top 30 most funded campaigns on Kickstarter in the tabletop games category. Based on our cross-case study, we identify and categorise tactics that create engagement-friendly environments. Our findings suggest that over time creators tend to focus on shorter but more dynamic campaigns with the higher engagement of backers. The creators of the best campaigns use similar tactics that affect both engagement and involvement. The important but often ignored factor that influences engagement is social interaction.
A Single-Center Evaluation of Environmental Emissions from ENDS and Combustible Cigarettes
Authors: Caraway John W. , Jin Tao , Schmidt Eckhardt , Nelson Paul R. 
Published: March 2022

Summary
As the use of electronic nicotine delivery systems (ENDS) continues to increase, there is a need to evaluate their impact on indoor air quality. This study evaluated the differences in concentrations of volatile and particulate compounds (including formaldehyde, benzene, glycerol, propylene glycol, nicotine, and particulate matter) in secondhand vapor (SHV) after ad libitum subject vaping of cig-a-like ENDS, after-subject smoking of combustible cigarettes (CC), and after-subject non-smoking/non-vaping (blank) in an environmental test chamber. A single-center, open-label, parallel-group study was conducted. Seventy-one generally healthy smokers and vapers were randomized to one of six cohorts: Marlboro Gold Pack, Newport Box, Vuse non-menthol (14 mg nicotine/cartridge and 29 mg nicotine/cartridge), Vuse menthol (29 mg nicotine/cartridge), and market-sample ENDS. Concentrations of most secondhand constituents were similar after e-cigarette vaping and blank sessions. Constituent concentrations in SHV after ENDS use were significantly lower than in secondhand smoke (SHS) from CC, with the exception of glycerol and propylene glycol. Secondhand nicotine concentrations after ENDS use were 88–99% lower than after cigarette smoking. Emission factors between the three Vuse products were also similar with the exception of propylene glycol. Concentrations of some secondhand constituents after ENDS use were compared to existing indoor and occupational air quality guidelines and did not show potential to contribute appreciably to indoor air quality. These findings indicate that SHV from ENDS differs qualitatively and quantitatively from the SHS from CC.