bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine-Scale Three-Dimensional Characterization of a Reservoir Comprising Braided River Sand Bodies with a Complex Stacking Pattern in a Cratonic Basin
Authors: Lou Jingyao , Zhao Zhongxiang , Shao Yanlin , Li Yang , Xu Xiaohong , He Youbin 
Published: October 2022

Abstract
The complex stacking pattern of braided river sand bodies in the cratonic basins results in a multilevel and multistage spatial distribution of reservoir units, which increases the difficulty of characterizing the spatial distribution pattern of reservoir parameters. Therefore, when characterizing the spatial regularity of this type of reservoir, it is necessary to consider the stacking pattern of the sand bodies to select the constraints. In this paper, the He 8 section of the Sulige 120 area in the Ordos Basin, China, is taken as an example. First, based on analysis of the development scale and genetic type of sand bodies in the area, four sand body stacking patterns and plan-view distribution patterns are identified. Second, a study on how to improve the accuracy of braided river sand body models is carried out, and a sand body model is established. Finally, a three-dimensional model of reservoir properties is established by using the sequential Gaussian simulation method under the constraint of the phase control model. The model results show that the three-dimensional model of the sand bodies established by the multipoint geostatistical method has better connectivity and is more suitable for constructing sand body models under complex sand body stacking conditions. The training images established by the target body method can clearly identify the boundary of the main channel of the braided river and solve the discontinuity of the sand body distribution. The reservoir model established under the constraint of the sand body model can effectively simulate the nonhomogeneity in the reservoir parameters, which can play a crucial role in accurately predicting the porosity and permeability distribution patterns of reservoirs with complex sand body stacking pattern. The present study provides a new idea for characterizing complexly stacked sand body reservoirs in a cratonic basin.
Improving Run Life in PCP Wells with CO2 and H2S Concentrations Using Tungsten-Alloy-Coated Rods and Couplings
Authors: Al Asmi Azzan , Landgraf Christian , Al Abri Hilal , Montilla Benigno , Caridad Jose , Perez Pedro , Wyninegar William 
Published: October 2022

Abstract
The company Petrogas E&P was established in 1999 by acquiring onshore block 7 in Oman. Over 23 years, Petrogas E&P has continuously grown by acquiring several blocks in Oman, India, Mozambique, Egypt, Netherlands, Germany, Denmark and in the United Kingdom.
The main operations are in Oman, Netherlands and in the UK. Since 2007, Petrogas is the operator of Rima Cluster small fields in southern Oman. Artificial lift, mainly rod driven Progressive Cavity Pumps (PCPs) and Beam Pumps (BPs), is required to produce oil with an average specific gravity of 21 °API to surface. Parted rods are the main reasons of well failures and rods present the weakest part of the completion. Some of the wells in Petrogas Rima show high angles of inclination, complex trajectories and certain levels of hydrogen sulfide (H2S) & carbon dioxide (CO2). Completion failures due to parted rods lead to production deferment and workover interventions because of required rod string replacement. In general, sucker rods are made of a certain grade of steel and these steels are prone to corrosion in an aggressive environment due to the presence of carbon dioxide and sulfide in the crude oil.
A coating solution for sucker rods and couplings was implemented to reduce the influence of corrosive environment in some wells. The lower coefficient of friction resulting from the coating reduces the abrasion between the coupling and the tubing. In that way, the risk of tubing holes can be reduced. After a coating solution was implemented in selected problematic wells, the rod run life could in average been tripled with no failures observed as of this writing.
Dopamine error signal to actively cope with lack of expected reward
Authors: Ishino Seiya , Kamada Taisuke , Sarpong Gideon , Kitano Julia , Tsukasa Reo , Mukohira Hisa , Sun Fangmiao , Li Yulong , Kobayashi Kenta , Honda Naoki , Oishi Naoya , Ogawa Masaaki 
Published: October 2022

Abstract
To obtain more of a particular uncertain reward, animals must learn to actively overcome the lack of reward and adjust behaviour to obtain it again. The neural mechanisms underlying such coping with reward omission remain unclear. Here we developed a task in rats to monitor active behavioural switch toward the next reward after no-reward. We discovered that some dopamine neurons in the ventral tegmental area exhibited increased responses to unexpected reward omission and decreased responses to unexpected reward, following the opposite responses of the well-known dopamine neurons that signal reward prediction error (RPE). The dopamine increase reflected in the nucleus accumbens correlated with behavioural adjustment to actively overcome unexpected no-reward. We propose that these responses signal error to actively cope with lack of expected reward. The dopamine error signal thus cooperates with the RPE signal, enabling adaptive and robust pursuit of uncertain reward to ultimately obtain more reward.
T cell activation, immune synapse formation, and organ infiltration by leukemic T cells require cortactin
Authors: Castellanos-Martínez Ramón , León-Vega Iliana I. , Guerrero-Fonseca Idaira M. , Vargas-Robles Hilda , Jiménez-Camacho Karina E. , Hernández-Galicia Gabriela , Ortiz-Navarrete Vianney F. , Rottner Klemens , Medina-Contreras Oscar , Schnoor Michael 
Published: October 2022

Abstract

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that is still fatal in many cases. T cell blasts are characterized by hyperactivation and strong proliferative and migratory capacities. The chemokine receptor CXCR4 is involved in mediating malignant T cell properties and cortactin has been shown to control CXCR4 surface localization in T-ALL cells. We have previously shown that cortactin overexpression is correlated with organ infiltration and relapse in B-ALL. However, the role of cortactin in T cell biology and T-ALL remains elusive. Here, we analyzed the functional relevance of cortactin for T cell activation and migration and the implications for T-ALL development. We found that cortactin is upregulated in response to TCR engagement and recruited to the immune synapse in normal T cells. Loss of cortactin caused reduced IL-2 production and proliferation. Cortactin-depleted T cells showed defects in immune synapse formation and migrated less due to impaired actin polymerization in response to TCR and CXCR4 stimulation. Leukemic T cells expressed much higher levels of cortactin compared to normal T cells that correlated with greater migratory capacity. Xenotransplantation assays in NSG mice revealed that cortactin-depleted human leukemic T cells colonized the bone marrow significantly less and failed to infiltrate the central nervous system suggesting that cortactin overexpression drives organ infiltration, which is a major complication of T-ALL relapse. Thus, cortactin could serve as a potential therapeutic target for T-ALL and other pathologies involving aberrant T cell responses.
Characterization of a unique Sikkimese yak population of India: A Multivariate approach
Authors: AGGARWAL RAK , Kour Aneet , GANDHI R.S. , NIRANJAN SAKET , PAUL VIJAY , BHUTIA TENZING LOBSANG , BHUTIA KARMA DOMA 
Published: October 2022

Abstract

Native Sikkimese yak in Sikkim state of India is a pastoral treasure being raised through centuries-old transhumance practices and has evolved in response to natural and man-made selection. Currently, the population of Sikkimese yak is at risk with about five thousand total headcounts. Characterization is essential for taking appropriate decisions for conservation of any endangered population. In an attempt to characterize the Sikkimese yaks, this study recorded phenotypic morphometric traits information viz. body length (LG), Height at withers (HT), Heart Girth (HG), Paunch Girth (PG), Horn Length (HL), Horn Circumference (HC), Distance between Horns (DbH), Ear Length (EL), Face Length (FL), Face Width (FW) and Tail Length with Switch (TL) on 2154 yaks of both sexes. Multivariate approach used to analyze the recorded data revealed high positive correlations between HG and PG in both the sexes and three principal components (PCs) were found to explain more than 70 percent of the population variance cumulatively. Subsequently, discriminant analysis indicated an overall genetic uniformity within Sikkimese yak population. Phenotypic characterization of Sikkimese yaks can further pave the way for preparing future conservation strategy.
Effectiveness of Antenatal Dexamethasone in Reducing Respiratory Distress Syndrome and Mortality in Preterm Neonates: a Nested Case Control Study
Authors: Kibanga Wema , Mutagonda Ritah F. , Moshiro Robert , Mareale Alphonce , Kilonzi Manase , JMlyuka Hamu , Mikomangwa Wigilya P , Kunambi Peter P. , Kamuhabwa Appolinary , Minzi Omary Mashiku 
Published: October 2022

Abstract

Background: Respiratory distress syndrome (RDS) is a significant cause of preterm neonatal morbidity and mortality globally. Measures like the use of antenatal corticosteroids (ACS) and immediate resuscitation of the newborn after birth are taken to abate preterm related complications. Most studies that evidenced the benefit of ACS were done in high resource settings. However, some studies in low resource settings reported no benefit of ACS in improving preterm neonatal outcomes. Therefore, this study was conducted to assess the effectiveness of ACS in reducing RDS and neonatal mortality in preterm neonates in resource-limited settings.
Methods: A three months nested case-control study (1:2 unmatched) was conducted at Muhimbili National Hospital and Amana regional referral hospital in Dar es salaam, Tanzania. Neonates delivered at 28 to 34 gestational weeks were enrolled and followed up until discharge. Cases were neonates with RDS and controls were those without. Data analysis was done using the statistical package of social sciences version 23. Logistic regression analysis was used to determine the predictors of RDS among preterm neonates. All tests were considered statistically significant at p <0.05.
Results: Out of 330 preterm neonates enrolled, 110 were cases and 220 were controls. The median gestational age at delivery was 30 weeks and 6 days (28-34) among cases and 33 weeks (28-34) among controls. One-minute APGAR score of less than 7 (AOR: 3.11; 95% CI 1.54-6.30), and neonatal birth weight (AOR: 0.998; 95% CI 0.997-0.999) were significantly associated with RDS. No significant association was observed between ACS exposure and RDS occurrence (AOR: 0.81; 95% CI 0.69-0.94). The overall mortality rate was 9 per 1000 neonates. Neonatal mortality occurred only among cases whereby, a unit increase in gestational age was associated with a 30% reduction in neonatal mortality (Adjusted hazard ratio, AHR: 0.70, 95% CI: 0.5-0.92, p=0.011).
Conclusion: Decrease in gestational age, one minute APGAR score of < 7 and low birth weight were associated with RDS among preterm neonates. ACS was not associated with reduced RDS occurrence and neonatal mortality rates. Moreover, increase in gestation age was the only factor found to be protective against preterm neonatal mortality.
Eye2Gene: prediction of causal inherited retinal disease gene from multimodal imaging using deep-learning
Authors: Pontikos Nikolas , Woof William , Veturi Advaith , Javanmardi Behnam , Ibarra-Arellano Miguel , Hustinx Alexander , Moghul Ismail , Liu Yichen , Heß Kristina , Georgiou Michalis , Pfau Maximilian , Shah Mital , Yu Jing , Al-Khuzaei Saoud , Wagner Siegfried , Varela Malena Daich , de Guimarães Thales Cabral , Sen Sagnik , Kabiri Nathaniel , Nguyen Quang , Furman Jennifer , Liefers Bart , Lee Aaron , De Silva Samantha , Texeira Caio , Motta Fabiana , Fujinami-Yokokawa Yu , Arno Gavin , Fujinami Kaoru , Sallum Juliana , Madhusudhan Savita , Downes Susan , Holz Frank , Balaskas Konstantinos , Webster Andrew , Mahroo Omar , Krawitz Peter , Michaelides Michel 
Published: October 2022

AbstractRare eye diseases such as inherited retinal diseases (IRDs) are challenging to diagnose genetically. IRDs are typically monogenic disorders and represent a leading cause of blindness in children and working-age adults worldwide. A growing number are now being targeted in clinical trials, with approved treatments increasingly available. However, access requires a genetic diagnosis to be established sufficiently early. Critically, the timely identification of a genetic cause remains challenging. We demonstrate that a deep-learning algorithm, Eye2Gene, trained on the largest imaging dataset of patients with IRDs currently available, provides expert-level accuracy for genetic diagnosis for the 36 most common molecular causes (top-5 accuracy = 85.6%). This algorithm has been deployed online (app.eye2gene.com) and externally validated on data provided by four different clinical centers. Eye2Gene can facilitate access to diagnostic expertise, only currently available in a limited number of specialist centers globally, and thereby dramatically accelerate the genetic diagnostic odyssey.
Too many dogs in the park I: Comparing four methods for estimating the abundance of open populations of free-ranging dogs in the Tehuacan-Cuicatlan Biosphere Reserve, Mexico.
Authors: Reina-Ponce Orlando , Weber Manuel , Perez-Jimenez Juan Carlos , Zapata-Rios Galo 
Published: October 2022

Abstract
The Tehuacan Cuicatlan Biosphere Reserve (TCBR), encompasses several human settlements, in addition to a garbage dump that serves as the main subsidy to maintain populations of free-ranging dogs (FRD) and feral dogs (FD), Canis lupus familiaris. Little is known about the best monitoring methods to estimate population indicators of FRD. Four monitoring methods were applied: one method applied exclusively for the garbage dump, and three different methods in two sampling sites, over the same spatial scale, to estimate the population indicators that guide decision-making on mitigation measures in the presence of FRD in protected natural areas (PNA). FRD monitoring is an essential activity for the management and control of their free-living populations, mainly in PNA, where they can become harmful to the environment. Through the application of four different monitoring methods to estimate FRD population indicators, we determined which of these are best adapted to varied sampling efforts. Traditional monitoring methods and, specifically, the capture-mark-recapture method applied to FRD are mainly designed for closed populations. Due to the complexity of free-living monitoring, and since FRD are reclusive in the presence of humans, we adapted a method for an open population at a landfill, mainly based on a study conducted in India. The four methods used in FRD monitoring in open populations show advantages and disadvantages, but we consider that in some situations (e.g., costs, execution time, materials, etc.) the capture-mark-recapture (C-M-R) model based on photographs and individual identification best fits most sampling models in relation to sampling effort, analysis, and expected outcomes.
Sex-specific switching of responsive immune pathways in vaccinated diabetic murine model exposed to influenza infection
Authors: Sengupta Anirban , Al-Otaibi Noha , Hinkula Jorma 
Published: October 2022

Abstract
Seasonal influenza vaccination has different implications on the immune response depending on the comorbidities. Diabetes is one such critical disease that increases the patient’s susceptibility to influenza and suppresses vaccine efficacy and immunity. The sex of the individuals also plays a definitive role in it. This study aims to understand the efficacy of the seasonal vaccine against influenza in diabetic groups and undergoing immune mechanisms in both sexes. There is a switching of the female with diabetes towards stronger cell-mediated immunity and Th1/Th17 response with suppressed humoral immunity. They show enhanced proinflammatory activities within T cells, CD8T activation, Th17 proliferation, and the majority of IgG2 antibody subtypes with reduced neutralization potential. Males with diabetes exhibit enhanced humoral Th2-immunity than the non-diabetic group. They exhibit higher MHCII, and DEC205 levels in dendritic cells, an increase in plasma B lymphocytes, and influenza-haemagglutinin specific IgG titer with stronger virus neutralization potential. This study highlights the critical immune mechanisms and sex-specific swapping of their preferred immune response pathways against influenza after vaccination during diabetes. We propose a need for a sex-specific customized vaccine regimen to be implemented against influenza for individuals having diabetes to exploit the manifested strength and weakness in their protective immunity.
UHPLC-HRMS-Based Serum Untargeted Lipidomics: PCs and SMs are the Main disturbed lipid markers to Distinguish Colorectal Advanced Adenoma from Cancer
Authors: Zhu Yifan , Zhou Hailin , Chen Hongwei , Zhang Jiahao , Liang Yunxiao , Zhu Pingchuan , Hua Chaolei , Zhang Qisong 
Published: October 2022

Abstract
Background
Colorectal advanced adenoma (CAA) is a key precancerous lesion of colorectal cancer (CRC), and early diagnosis can lessen CRC morbidity and mortality. Although abnormal lipid metabolism is associated with the development of CRC, there are no studies on the biomarkers and mechanisms of lipid metabolism linked to CAA carcinogenesis. Methods: The serum lipidomics was investigated with CAA (N = 46) and CRC (N = 50) patients by ultra high-performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) in both electrospray ionization (ESI) modes. Differential lipids were selected by univariate and multivariate statistics analysis, and their diagnostic performance was evaluated using a receiver operating characteristic curve (ROC) analysis.
Results
Combining P < 0.05 and variable importance in projection (VIP) > 1, 59 differential lipids were obtained totally. Ten of them showed good discriminant ability for CAA and CRC (AUC > 0.900). Especially, the lipid panel consisting of PC 44:5, PC 35:6e, and SM d40:3 showed the highest selection frequency and outperformed (AUC = 0.952). Additionally, phosphatidylcholine (PC) and sphingomyelin (SM) were the main differential and high-performance lipids.
Conclusions
PC and SM are the main biomarker candidates to distinguish CAA from CRC, and dysregulated metabolism of them may play a key role in CAA carcinogenesis.
Tidal effect on nitrate and dissolved organic carbon concentrations in river water in the Bekanbeushi River watershed in eastern Hokkaido, northern Japan
Authors: Shibata Hideaki , Takeuchi Shota , Ding Manhui , Shiraiwa Takayuki , Katsuyama Masanori , Nakaoka Masahiro , Nakada Satoshi , Nagao Seiya 
Published: October 2022

Abstract
Downstream wetlands play an important role as an interface between terrestrial and coastal areas, and nutrients and dissolved organic matter in downstream rivers are recognized as important parameters for various ecosystem functions and services in the watershed ecosystem. In this study, nitrate nitrogen and dissolved organic carbon in river water were observed with high temporal resolution at 10-minute intervals using water quality sensors in the downstream wetland area of the Bekanbeushi River watershed in northern Japan. The river water flow was similarly measured to examine the relationship between water quality and riverine volume transport in downstream river water under the influence of tidal fluctuations. The tidally induced cycles of riverine volume transport (i.e., discharge (tidal ebb) and backflow (tidal flood)) had a nonnegligible effect on the concentration-flow (C-Q) relationships of nitrate nitrogen and dissolved organic carbon. Tidal saltwater upwelling was also found to disturb the C-Q relationship by increasing the nitrate-nitrogen concentrations and decreasing the dissolved organic carbon concentrations. Intense rainfall infiltration also contributed to the reduction in the concentrations of both components. The results suggest that changes in hydrologic processes due to tidal fluctuations and heavy rainfall have a nonnegligible effect on nutrient and dissolved organic matter concentrations in downstream watersheds.
GBA/GBN-position on the feedback of incidental findings in biobank-based research: consensus-based workflow development and pilot implementation
Authors: Geiger Joerg , Fuchs Jörg , Starke Madeline , Neumann Michael , Baber Ronny , Nussbeck Sara , Kiehntopf Michael , Specht Cornelia , Illig Thomas , Hummel Michael , Jahns Roland 
Published: October 2022

Abstract
Incidental research findings pose a considerable challenge to clinical biobanks since they are acting as intermediaries between healthcare and research. In a joint action the centralized biobank ibdw (Interdisciplinary Bank of Biomaterials and Data Wuerzburg) together with local authorities drafted a coherent concept to manage incidental research findings in full compliance with ethical and data privacy regulations. The concept was developed and elaborated in close collaboration with the German Biobank Alliance (GBA). The first implementation was piloted and evaluated in a testbed. Comprehensive documentation of all steps guarantees the traceability of the process. By a mandatory assessment of the findings prior to re-identification of the individual concerned, unnecessary measures can be avoided. The individual's right to “not to know” is respected according to the stipulations of the informed consent. As a general principle any communication with the individual occurs exclusively through the hospital and by competent physicians with appropriate knowledge and communication skills. We propose this scheme as a blueprint for reporting workflows for incidental research findings at hospital-integrated biobanks.
Performance and Protection of Pre-Engineered Buildings Subjected to Blast and Earthquake Excitations
Authors: Kangda Muhammed Zain , Sah Subhash Kumar , Bakre Sachin 
Published: October 2022

Abstract
Technological advancements and improvements with time have significantly contributed to improve the living standards with new kind of products and utilities. An example of such technological improvement in structural engineering is Pre-Engineered Building (PEB). This concept includes pre-designing and pre-fabrication processes. A Pre-Engineered Building (PEB) refers to a building which is pre-designed at a factory using some simulation and modelling software as per the specifications, codes and the loads that will be acting on the structure before production of the building components and then finally assembled at site thereby reducing the completion time. In the current study, a case study of an existing PEB structure subjected to wind analysis has been investigated. The main objective of the present study is to evaluate the retrofitting ability of passive control dampers in the event of an earthquake or blast phenomenon. The study shows the effectiveness of vibration control techniques in the form of passive dampers in improving the performance of PEB structure subjected to blast and earthquake using fluid viscous dampers. The study also discusses the impact of different damper placements and properties on the structural performance of PEB structure subjected to blast and earthquake. Primarily three damper placement techniques are incorporated in the present study namely single diagonal, V-shaped damper and inverted V-shaped damper. The structural performance of PEB structure has been studied using finite element tool considering the non-linear analysis and comparing the structural responses for with and without damper conditions. The V-shaped and inverted V-shaped damper placement technique is the most effective approach in resisting the damaging effects against blasts and earthquakes for the selected PEB structure in comparison to the conventional diagonal braced dampers.