bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of circulating small extracellular vesicle-derived miRNAs as diagnostic biomarkers for differentiating between different pathological types of early lung cancer
Authors: Jiang Yi-fang , Wei Shan-na , Geng Nan , Qin Wen-wen , He Xin , Wang Xiu-huan , Qi Yao-pu , Song Shan , Wang Ping 
Published: October 2022

AbstractLung cancer is the leading cause of cancer-related death worldwide. MicroRNAs (miRNAs) in circulating small extracellular vesicles (sEVs) have been suggested to be potential biomarkers for cancer diagnosis. The present study was designed to explore whether plasma-derived sEV miRNAs could be utilized as diagnostic biomarkers for differentiating between early-stage small cell lung cancer (SCLC) and early-stage non-small cell lung cancer (NSCLC). We compared the miRNA profiles of plasma-derived sEVs from healthy individuals, patients with early-stage SCLC and patients with early-stage NSCLC. Next-generation sequencing was used to screen for differentially expressed miRNAs (DEMs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to predict the potential functions of these DEMs. Weighted gene coexpression network analysis (WGCNA) was used to identify the different pathology-related miRNA modules. We found that 22 DEMs were significantly different among healthy individuals, patients with early-stage SCLC, and patients with early-stage NSCLC. We selected six representative DEMs for validation by qRT‒PCR, which confirmed that miRNA-483-3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA-152-3p and miRNA-1277-5p could be used for the diagnosis of early-stage NSCLC respectively.
Nanosheet fabrication from magnon thermal conductivity cuprates for the advanced thermal management
Authors: Kinoshita Hiroya , Terakado Nobuaki , Takahashi Yoshihiro , Miyazaki Takamichi , Ishikawa Chitose , Naruse Koki , Kawamata Takayuki , Fujiwara Takumi 
Published: October 2022

AbstractSpin-chain–spin-ladder cuprates, such as La5Ca9Cu24O41, have notable electronic and thermal properties because of their unique electron spin arrangement. Among them, magnon thermal conductivity, which originates from the excitation of paired electron spins, is promising for the advanced thermal management applications that enable dynamic control of heat flow. This is because of its high, anisotropic thermal conductivity at room temperature and its dynamic controllability. In this study, we report nanosheet fabrications from polycrystalline La5Ca9Cu24O41 to enhance the control width. We obtained that the nanosheets with a thickness of about 3 nm are obtained via immersion of the polycrystals in a NaOH aqueous solution. We propose the exfoliation model based on the chemical reaction between the (La/Ca)2Cu2O3 subsystem and NaOH solution. The nanosheet fabrications can also lead to new research development on spin-ladder system and other strongly correlated cuprates.
Wildfires disproportionately affected jaguars in the Pantanal
Authors: de Barros Alan Eduardo , Morato Ronaldo Gonçalves , Fleming Christen H. , Pardini Renata , Oliveira-Santos Luiz Gustavo R. , Tomas Walfrido M. , Kantek Daniel L. Z. , Tortato Fernando R. , Fragoso Carlos Eduardo , Azevedo Fernando C. C. , Thompson Jeffrey J. , Prado Paulo Inácio 
Published: October 2022

AbstractThe Pantanal wetland harbours the second largest population of jaguars in the world. Alongside climate and land-use changes, the recent mega-fires in the Pantanal may pose a threat to the jaguars’ long-term survival. To put these growing threats into perspective, we addressed the reach and intensity of fires that have affected jaguar conservation in the Pantanal ecoregion over the last 16 years. The 2020 fires were the most severe in the annual series, burned 31% of the Pantanal and affected 45% of the estimated jaguar population (87% of these in Brazil); 79% of the home range areas, and 54% of the protected areas within home ranges. Fires consumed core habitats and injured several jaguars, the Pantanal’s apex predator. Displacement, hunger, dehydration, territorial defence, and lower fecundity are among the impacts that may affect the abundance of the species. These impacts are likely to affect other less mobile species and, therefore, the ecological stability of the region. A solution to prevent the recurrence of mega-fires lies in combating the anthropogenic causes that intensify drought conditions, such as implementing actions to protect springs, increasing the number and area of protected areas, regulating fire use, and allocating fire brigades before dry seasons.
Photoelectrocatalytic hydrogen generation coupled with reforming of glucose into valuable chemicals using a nanostructured WO3 photoanode
Authors: Jakubow-Piotrowska Katarzyna , Witkowski Bartłomiej , Augustynski Jan 
Published: October 2022

AbstractCoupling the photo-oxidation of biomass derived substrates with water splitting in a photoelectrochemical (PEC) cell is a broadly discussed approach intended to enhance efficiency of hydrogen generation at the cathode. Here, we report a PEC device employing a nanostructured semitransparent WO3 photoanode that, irradiated with simulated solar light achieves large photocurrents of 6.5 mA cm−2 through oxidation of glucose, a common carbohydrate available in nature that can be obtained by processing waste biomass. The attained photocurrents are in a large part due to the occurrence of the photocurrent doubling, where oxidation of glucose by the photogenerated positive hole is followed by injection by the formed intermediate of an electron into the conduction band of WO3. Selection of an appropriate supporting electrolyte enabled effective reforming of glucose into valuable products: gluconic and glucaric acids, erythrose and arabinose with up to 64% total Faradaic yield attained at ca 15% glucose conversion.
A Dynamic Adjust‐Head Siamese network for object tracking
Authors: Qiu Shoumeng , Gu Yuzhang , Chen Minghong , Yuan Zeqiang , Yao Zehao , Zhang Xiaolin 
Published: October 2022

AbstractSiamese network based trackers formulate tracking as a similarity matching problem between a target template and a search region. Virtually all popular Siamese trackers use cross‐correlation to measure the similarity between the deep feature of template and search image. However, the emphasis for feature extraction in different parts of the image are the same. Besides, the global matching between the template and search region also seriously neglects the part‐level information and the deformation of targets during tracking. In this study, to tackle the above issues, a simple but effective Dynamic Adjust‐Head (SiamDAH) model is proposed to extract features from different parts of an object. In addition, an improved pixelwise cross‐correlation model (PWCC) is designed to enhance the naive cross‐correlation operation to produce multiple similarity maps associated with different parts of the target. Experiments on serval challenging benchmarks including OTB‐100, GOT‐10k, LaSOT, and TrackingNet demonstrate that the proposed SiamDAH outperforms many state‐of‐the‐art trackers and achieves leading performance.
GS 121–05–037: A new Galactic chimney candidate with signs of triggered star formation
Authors: Suad L. A. , Molina Lera J. A. , Cichowolski S. 
Published: October 2022

Aims. The goal of this study is to analyze the H i supershell GS 121–05–037 and its role in triggering star formation.
Methods. To characterize the supershell, we analyzed the H i 21-cm line and the far-infrared emission distributions. In addition, to study the star formation processes related to GS 121-05-037, we used the Gaia survey, together with spectrophotometric calculations, and derived a method to look for massive OB–type stars.
Results. The H i characterization of GS 121–05–037 shows an expanding structure centered at (l, b) ~ (121°.3, −4°.8) in the velocity range from −47.8 to −25.2km s−1. It is located at 3.2 ± 1.0 kpc from the Sun and has a kinetic energy of Ek = (2.1 ± 1.3) × 1050 erg. GS 121 −05−037 presents, in the H i emission distribution, an open morphology toward the Galactic halo. The analysis of the IR emission reveals the presence of 32 Hii regions seen projected into the borders of GS 121–05–037. A spectrophotometric analysis to look for the ionizing stars of these regions reveals that 12 of them would be located at a similar distance to GS 121–05–037.
Conclusions. The relative location between GS 121–05–037 and the Hii regions, together with their age difference, led us to conclude that the ionizing stars could have been created due to the expansion of the H i supershell. On the other hand, the Hii regions located on the interface of two or more supershells could have originated from the collision of the H i structures. Finally, the open morphology of GS 121 –05–037 toward the halo suggests that this large structure could be a Galactic chimney.
L’activité physique adaptée comme stratégie de prévention et de traitement des maladies chroniques : les cas du diabète de type II
et de la dépression
Authors: Boiche Julie , Carré François , Fervers Béatrice , Freyssenet Damien , Gremy Isabelle , Guiraud Thibaut , Moro Cédric , Nguyen Christelle , Poiraudeau Serge , Ninot Grégory , Perrin Claire , Varray Alain , Vinet Agnès , Walther Guillaume 
Published: October 2022

L’activité physique adaptée (APA) se définit comme une activité physique ou sportive adaptée aux
capacités de personnes à besoins spécifiques : atteintes de maladies chroniques, vieillissantes, en situation
de handicap ou vulnérables. Elle mobilise des connaissances scientifiques pluridisciplinaires pour évaluer
les ressources et les besoins des individus et concevoir avec eux des dispositifs et des projets
d’intervention sportifs ou artistiques adaptées à des fins de prévention, de réadaptation, d’inclusion,
d’éducation ou de participation sociale. Au-delà de l’accessibilité de la pratique, elle cherche surtout à
créer les conditions du développement d’un projet personnel d’activité physique durable, qui s’intègre au
parcours de vie des individus. Sollicitée par le ministère des Sports, l’Inserm a réalisé une expertise
collective faisant le bilan des connaissances scientifiques sur l’APA, afin d’analyser, dans le cadre des
maladies chroniques, son impact et sa place dans le parcours de soin. S’appuyant sur les résultats de cette
expertise collective, ce nouveau numéro de Question de Santé Publique présente le cas du diabète de type
II et de la dépression. Face au vieillissement de la population, l’APA est aujourd’hui devenue un nouvel
enjeu de santé publique dont les conditions politiques, sociales, organisationnelles et professionnelles de
son émergence restent à définir, ainsi que les caractéristiques des programmes d’activité les plus
efficients. Pour le diabète de type II et la dépression, comme pour les autres pathologies chroniques, les
bénéfices des programmes d’APA sont bien supérieurs aux risques, lorsque les conseils et les
recommandations de pratiques sont respectées et que celles-ci sont personnalisées en fonction des
caractéristiques individuelles et du contexte de vie de chaque patient.
COVID-19 in der Schwangerschaft: Ursache für eine
intrakranielle Blutung bei einem Frühgeborenen?
Authors: Klüßendorf Anne , Richter Manuela F. , Webermann Santje , Schild Ralf L. , Morfeld Christine A. 
Published: October 2022

AbstractMaternity clinics are increasingly being confronted with pregnant women suffering
from Covid-19. This poses great challenges for obstetricians, since some
questions have not yet been adequately researched scientifically. Not much is
known about COVID-19 during pregnancy and its effects on the unborn and newborn
child.
Reconfiguring a Chinese superhero through the dubbed versions of Monkey King: Hero is Back (2015)
Authors: Liang Lisi 
Published: October 2022

AbstractThe paper aims to investigate how a Chinese heroic legend was reconfigured for Western viewers through the English-dubbed versions of a case-study film, Monkey King: Hero is Back (2015). The ultimate goal of the study is to shed new light on how dubbing practice may better cater to Western target audiences. Based on two macrolevel translation theories, three translation models, and the two microlevel translation strategies, this paper discusses the most commonly used film translation strategies for English dubbing in the case-study film and their implications for the effectiveness of translation. The findings suggest that driven by the target-audience orientation, English-dubbing strategies often use standard language constrained by linguistic and cultural disparities as opposed to dynamic, adaptive Chinese dubbing.
Jacobi equations of geodetic brane gravity
Authors: Capovilla Riccardo , Cruz Giovany , Rojas Efraín 
Published: October 2022

Abstract
We consider brane gravity as described by the Regge–Teitelboim geometric model, in any co-dimension. In brane gravity our spacetime is modelled as the time-like world volume spanned by a space-like brane in its evolution, seen as a manifold embedded in an ambient background Minkowski spacetime of higher dimension. Although the equations of motion of the model are well known, apparently their linearization has not been considered before. Using a direct approach, we linearize the equations of motion about a solution, obtaining the Jacobi equations of the Regge–Teitelboim model. They take a formidable aspect. Some of their features are commented upon. By identifying the Jacobi equations, we derive an explicit expression for the Morse index of the model. To be concrete, we apply the Jacobi equations to the study of the stability of a four-dimensional Schwarzschild spacetime embedded in a six-dimensional Minkowski spacetime. We find that it is unstable under small linear deformations.
Efficient derivative-free Bayesian inference for large-scale inverse problems
Authors: Huang Daniel Zhengyu , Huang Jiaoyang , Reich Sebastian , Stuart Andrew M 
Published: October 2022

Abstract
We consider Bayesian inference for large-scale inverse problems, where computational challenges arise from the need for repeated evaluations of an expensive forward model. This renders most Markov chain Monte Carlo approaches infeasible, since they typically require

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model runs, or more. Moreover, the forward model is often given as a black box or is impractical to differentiate. Therefore derivative-free algorithms are highly desirable. We propose a framework, which is built on Kalman methodology, to efficiently perform Bayesian inference in such inverse problems. The basic method is based on an approximation of the filtering distribution of a novel mean-field dynamical system, into which the inverse problem is embedded as an observation operator. Theoretical properties are established for linear inverse problems, demonstrating that the desired Bayesian posterior is given by the steady state of the law of the filtering distribution of the mean-field dynamical system, and proving exponential convergence to it. This suggests that, for nonlinear problems which are close to Gaussian, sequentially computing this law provides the basis for efficient iterative methods to approximate the Bayesian posterior. Ensemble methods are applied to obtain interacting particle system approximations of the filtering distribution of the mean-field model; and practical strategies to further reduce the computational and memory cost of the methodology are presented, including low-rank approximation and a bi-fidelity approach. The effectiveness of the framework is demonstrated in several numerical experiments, including proof-of-concept linear/nonlinear examples and two large-scale applications: learning of permeability parameters in subsurface flow; and learning subgrid-scale parameters in a global climate model. Moreover, the stochastic ensemble Kalman filter and various ensemble square-root Kalman filters are all employed and are compared numerically. The results demonstrate that the proposed method, based on exponential convergence to the filtering distribution of a mean-field dynamical system, is competitive with pre-existing Kalman-based methods for inverse problems.
Effects of dipolar coupling on an entanglement storage device
Authors: Saha Saptarshi , Bhattacharyya Rangeet 
Published: October 2022

Abstract
Quantum computation requires efficient long-term storage devices to preserve quantum states. An attractive candidate for such storage devices is qubits connected to a common dissipative environment. The common environment gives rise to persistent entanglements in these qubit systems. Hence these systems act efficiently as a storage device of entanglement. However, the existence of a common environment often requires the physical proximity of the qubits and hence results in direct dipolar coupling between the qubits. In this work, we investigate effects of the secular and the nonsecular part of the dipolar coupling on the environment-induced entanglement using a recently-proposed fluctuation-regulated quantum master equation (Chakrabarti and Bhattacharyya 2018 Phys. Rev. A 97 063837). We show that nonsecular part of the dipolar coupling results in reduced entanglement and hence less efficiency of the storage devices. We also discuss the properties of efficient storage that mitigates the detrimental effects of the dipolar coupling on the stored entanglement.
Kinetic models of quantum size effect-directed nanocluster self-assembly in atomic corrals
Authors: Khenner Mikhail 
Published: October 2022

Abstract
Two simple kinetic models of quantum size effect-directed nanocluster self-assembly in circular atomic corrals are discussed. The models correspond to an adsorption (either a physisorption or a chemisorption) and an adsorption-diffusion regimes that are typical at low and high temperatures, respectively. Small magnitudes of a variation of the electronic local density of states is shown to be the prime factor that impedes self-assembly in the latter regime.
Estimation method for the anisotropic electrical conductivity of in vivo human muscles and fat between 10 kHz and 1 MHz
Authors: Kangasmaa Otto , Laakso Ilkka 
Published: October 2022

Abstract

Objective. In low frequency dosimetry the variability in the electrical conductivity values assigned to body model tissues represents a major source of uncertainty. The aim of this study is to propose a method for estimating the conductivity of human anisotropic skeletal muscle and fat in vivo in the frequency range from 10 kHz to 1 MHz. Approach. A method based on bounded electrical impedance tomography was used. Bioimpedance measurements were performed on the legs of ten subjects. Anatomically realistic models of the legs were then created using magnetic resonance images. The inverse problem of the tissue conductivities was solved using the finite element method. The results were validated using resampling techniques. These findings were also used to study the effects of muscle anisotropy on magnetic field exposure. Main results. The estimated conductivities for anisotropic muscle were found to be in good agreement with values found in existing literature and the anisotropy was shown to decrease with increasing frequency, with the ratio of lateral to longitudinal conductivity increasing from 37% to 64%. The conductivity of fat was found to be almost a constant 0.07 S m−1 in the frequency range considered. Significance. The proposed method was shown to be a viable option when estimating in vivo conductivity of human tissue. The results can be used in numerical dosimetry calculations or as limits in future investigations studying conductivity with bioimpedance measurements.
Highly efficient stable blue organic light-emitting diodes based on a novel anthracene[2,3-b]benzofuran framework
Authors: Sun Jun , Li Fei , Tian Mi , Yan Ziqiang , Hu Zongxue , Wang Chen , He Haixiao , Liu Kaipeng , Xu Fengjie , Zhang Hongke 
Published: October 2022

Abstract
Organic blue fluorescent emitters’ emissions are highly desirable for high-resolution organic light-emitting diode (OLED) display technology. In this work, a design strategy to realize narrowband emission of organic blue fluorescent emitters by connecting carbazole and amine, named ABFCz and ABFAn, respectively, with anthracene[2,3-b]benzofuran as rigid groups is reported for the first time. The developed materials can achieve high efficiency and long life. Studies of the doped devices show that ABFCz-based blue-emitting OLEDs achieve a maximum current efficiency of 6.96 cd A−1 with a narrow full width at half maximum (FWHM) of 44 nm, as well as a Commission Internationale de l’Eclairage (CIE) coordinate of (0.15, 0.14). A maximum external quantum efficiency (EQEmax) of 7.7% is also achieved. Meanwhile, the ABFAn emitter-based devices exhibit blue emission with a maximum current efficiency of up to 9.20 cd A−1 (EQEmax of 11.4%) with a FWHM of 44 nm, as well as a CIE coordinate of (0.14, 0.13). The devices are based on an ABFAn operating lifetime test LT90 (luminance decays to 90% of the initial brightness) of 202 h at an initial luminance of 1000 cd m−2. The results show that anthracene[2,3-b]benzofuran can be modified with a higher glass transition temperature (T
g) to achieve high-efficiency and stable-operating-lifetime blue light devices. Our work may provide a new approach for designing high-efficiency blue materials.
Feshbach spectroscopy of Cs atom pairs in optical tweezers
Authors: Brooks R V , Guttridge A , Frye Matthew D , Ruttley Daniel K , Spence S , Hutson Jeremy M , Cornish Simon L 
Published: October 2022

Abstract
We prepare pairs of 133Cs atoms in a single optical tweezer and perform Feshbach spectroscopy for collisions of atoms in the states (f = 3, m

f
= ±3). We detect enhancements in pair loss using a detection scheme where the optical tweezers are repeatedly subdivided. For atoms in the state (3, −3), we identify resonant features by performing inelastic loss spectroscopy. We carry out coupled-channel scattering calculations and show that at typical experimental temperatures the loss features are mostly centred on zeroes in the scattering length, rather than resonance centres. We measure the number of atoms remaining after a collision, elucidating how the different loss processes are influenced by the tweezer depth. These measurements probe the energy released during an inelastic collision, and thus give information on the states of the collision products. We also identify resonances with atom pairs prepared in the absolute ground state (f = 3, m

f
= 3), where two-body radiative loss is engineered by an excitation laser blue-detuned from the Cs D2 line. These results demonstrate optical tweezers to be a versatile tool to study two-body collisions with number-resolved detection sensitivity.