bluuebunny/crossref_metadata_2025_split huggingface dataset:
Government support for regional economy in the context of modern turbulence
Authors: Grishkov V. F. 
Published: November 2022

Aim. The presented study aims to analyze the instruments of government support for regional development in the context of political and economic turbulence caused by anti-Russian sanctions.Tasks. Through the example of the Leningrad region, the author describes the directions and effects of the macroeconomic shock caused by external sanctions on regional economy and systematizes measures of government support for the regional economy in the context of political and economic turbulence.Methods. This study uses the methods of retrospective and comparative analysis, analogy and observation, expert assessments, scenario approach, and special methods of regional research.Results. The performed analysis indicates that the impact of the macroeconomic shock caused by anti-Russian sanctions (2022) on the Russian economy is multidirectional. The degree and nature of its impact vary significantly by region and type of economic activity. However, despite its generally negative nature, this impact has not yet become critical. The analysis results show that the regional economy is sufficiently resistant to crisis challenges. At the same time, the negative impact manifested as a general drop in production volumes or a decrease in real wages is gradually increasing. Therefore, the authorities should be proactive in combating crisis phenomena. In the Leningrad region, such measures are taken actively and efficiently. These need to be focused primarily on supporting import substitution programs and reducing the level of import dependence.Conclusions. In the context of unprecedented sanctions, reducing the risks of import dependence is one of the key goals of sustainable economic development. The successful solution of import substitution problems today, i.e. as quickly as possible, is important not only for quickly curbing crisis phenomena and restoring the Russian economy back to normal, but also from the perspective of changing the region's economic specialization. The observed turbulence is causing a structural shift in the economy driven by the macroeconomic shock. It is recommendable to ensure the progressivity of the structural shift in the Leningrad region as it will be much more difficult to do this after the transition process is complete. In the context of the transition to a new technological paradigm in the economy, this will limit the competitiveness of the region.
Categorización de pacientes con sospecha de síndrome coronario agudo, según la definición universal
Authors: Ardila Sabogal Camila , Cano-Arenas Nairo , Acosta-Wilches Laura C. , Acosta-Gutiérrez Estivalis 
Published: November 2022

Objetivo: describir las características clínicas, imagenológicas y de laboratorio de pacientes llevados a arteriografía coronaria con diagnóstico presuntivo de síndrome coronario agudo, en el periodo comprendido entre enero de 2107 y diciembre 2019; así como las frecuencias de los tipos de infarto según la definición universal.
Metodología: estudio observacional de corte transversal, de pacientes mayores de 18 años llevados a coronariografía, en un hospital universitario de Bogotá. Mediante el software STATA, se realizó el análisis estadístico, con cálculo de frecuencias absolutas, proporciones, medidas de tendencia central y dispersión según el comportamiento de las variables. Se realizó la clasificación de pacientes según la cuarta definición universal de infarto, identificando cada una de las frecuencias respectivas.
Resultados: se analizaron 714 historias clínicas, correspondientes a 459 hombres y 255 mujeres, con hipertensión arterial, dislipidemia, obesidad, diabetes y enfermedad coronaria previa como factores de riesgo cardiovascular más frecuentes. El 68.9% de pacientes tuvo un electrocardiograma interpretado como anormal y solo 43.8% de pacientes tuvo lesiones obstructivas, de los cuales 33.2% correspondió a pacientes con infarto tipo I. Se encontró una prevalencia de 12.2% para infarto tipo II y del 17% para la categoría de MINOCA. La mortalidad intrahospitalaria fue de 2.5%, principalmente por choque cardiogénico.
Conclusiones: la población masculina con factores de riesgo cardiovascular, predominó en la presentación del síndrome coronario agudo. Para este estudio, la mayoría de los pacientes no tuvo lesiones obstructivas en la arteriografía. Sin embargo, dentro de los tipos de infarto; el infarto tipo I fue el más frecuente
INDIVIDUAL WORK PERFORMANCE, PUBLIC LEADERSHIP, AND PUBLIC SERVICE MOTIVATION: A CAUSAL MODEL ON PROFESSIONALISM AMONG THE PACIFICATION COMMITTEE (LUPONG TAGAPAMAYAPA) IN THE BARANGAYS
Authors: Leila Plaza-Saligumba  , Victoria O. Ligan  , Alger P. Dura  
Published: November 2022

This non-experimental quantitative study found a best-fit structural model of professionalism among 400 Lupong Tagapamayapa [LP] (Pacification) members in the barangays of Panabo City. Statistical tools used in analyzing data were the weighted mean, Pearson r, multiple linear regression, and structural equation modeling (SEM). Results exposed the high-level work performance, public leadership, public service motivation, and professionalism of the Lupong Tagapamayapa. Moreover, the correlation test yielded a significant linear relationship between leadership and professionalism and public service motivation and professionalism. However, the relationship between work performance and professionalism was insignificant. Subsequently, the regression result revealed a combined predictive capability of work performance, leadership, and public service motivation on professionalism. Furthermore, the structural equation modeling revealed that public leadership and public service motivation are predictors of professionalism with specific manifest variables: accountability and network governance for public leadership; compassion and self-sacrifice for public service motivation. These manifest variables can only predict professional ethos and challenge under the professionalism construct. Finally, the studys findings have implications for effective and efficient mediation protocols in the barangays. The paper contained further discussions and inferences about the results.
KEYWORDS:	public administration, lupong tagapamayapa, work performance, public leadership, public service motivation, professionalism, structural equation modeling, Panabo barangays
Relevés de température et méthodes d'étalonnage des thermomètres à l'Observatoire de Paris (1683-1732)
Authors: Chassefière Éric 
Published: November 2022

Cet article présente les mesures de température atmosphérique figurant dans les journaux d'observation des astronomes de l'Observatoire de Paris entre 1683 et 1732, en se focalisant sur le préalable indispensable que constitue l'étalonnage des thermomètres utilisés pour pouvoir convertir les données en degrés Celsius. À cette fin, nous caractérisons chacun des trois thermomètres à alcool utilisés, possédant son propre système de graduations, par deux températures de référence, celle observée dans les caves de l'Observatoire et celle mesurée quand l'eau gèle à proximité du lieu de la mesure. Nous obtenons ainsi une précision absolue sur les températures restituées de l'ordre de ±1 °C entre 0 et 20 °C, ±2 °C aux extrêmes. Une exploration préliminaire des données montre des écarts significatifs entre nos températures restituées et celles des séries historiques existantes, incitant à entreprendre une analyse plus détaillée du jeu de données de l'Observatoire, permettant notamment de combler le chaînon manquant de mesures de température in situ à Paris entre 1713 et 1732.
This article presents the atmospheric temperature measurements in the observation journals of the astronomers of the Paris Observatory between 1683 and 1732, focusing on the indispensable prerequisite of the calibration of the thermometers used to convert the data into °C. To this end, we characterize each of the three alcohol thermometers used, having its own system of graduations, by two reference temperatures, the one observed in the cellars of the Observatory and the one measured when the water freezes in the vicinity of the place of the measurement. We thus obtain an absolute precision on the temperatures returned of the order of ±1 °C between 0 and 20 °C, ±2 °C at the extremes. A preliminary exploration of the data shows significant discrepancies between our reconstructed temperatures and those of the existing historical series, prompting a more detailed analysis of the Observatory's dataset, allowing in particular to fill the missing link of in situ temperature measurements in Paris between 1713 and 1732.
Effect of Administration of Apium graveolens (Linn.) Extract on the Number of Neutrophils, Angiogenesis, and Fibroblast Density Areas in Sprague Dawley Rats Incision Wounds
Authors: Wijaya Yanuar Hendra , Najatullah  
Published: November 2022

Background: Wounds are a challenging clinical problem with complications that often lead to morbidity and mortality. The herbal plant Apium graveolens (Linn.) has anti-oxidant and anti-inflammatory effects, which are thought to accelerate the wound healing process. The number of neutrophils, angiogenesis, and the area of fibroblast density are elements that play an important role in the wound healing process. Thus, the administration of Apium graveolens (Linn.) extract is expected to assist in the wound healing process, which can be viewed from the number of neutrophils, angiogenesis, and the area of fibroblast density.
Methods: An experimental in vivo study with a randomized post-test approach with a control group of rats that were given an incision on their back. Random allocation was performed to divide 20 Sprague Dawley rats into 4 groups. Neutrophil count, angiogenesis, and area of fibroblast density were seen histopathologically. Data were analyzed and processed using SPSS 25 software in univariate, bivariate, and multivariate ways.
Results: The number of neutrophils, angiogenesis, and area of fibroblast density in the Apium graveolens (Linn.) extract group was lower than the group given the cream without Apium graveolens (Linn.) extract (p < 0.05), and there was no difference compared to the group given gentamicin cream. 0.1% (p > 0.05). Extract Apium graveolens (Linn.) had the lowest number of neutrophil and angiogenesis compared to the other groups (p < 0.05).
Conclusion: The administration of Apium graveolens (Linn.) extract cream was effective in the incision wound healing process in terms of a decrease in the number of neutrophils, angiogenesis, and the area of fibroblast density. The administration of Apium graveolens (Linn.) extract cream was more effective than 50% extract cream.
Pioartrite Em Recém-Nascido: Relato De Caso
Authors: Rodrigues Renan Brocchi de Moraes , Guerra Priscilla 
Published: November 2022

Introdução: A pioartrite (PIOA), também conhecida como artrite séptica, é uma monoartrite aguda causada principalmente por bactérias comuns, como as dos gêneros Staphylococcus ou Streptococcus. Embora a PIOA em crianças não seja comum, não deve ser subestimada, pois pode estar associada à sepse e resultar em disfunção grave ou morte se não tratada precocemente e de forma adequada. Objetivo: Relatar um caso de PIOA em recém-nascido atendido no Serviço de Pediatria do Hospital Universitário São Francisco na Providência de Deus (HUSF), localizado na cidade de Bragança Paulista, SP.
Relato do Caso: Tratou-se de um recém-nascido de 14 dias cujos pais relataram queixas de irritabilidade, choro excessivo à manipulação e diminuição da motilidade do membro inferior esquerdo, que se apresentava edemaciado e ruborizado na região do quadril. O paciente foi avaliado pela equipe de Ortopedia, que o diagnosticou com PIOA, realizando limpeza e drenagem do quadril afetado, seguida de 21 dias de antibioticoterapia combinada, com remissão completa da doença.
Conclusão: Por conta de sua raridade, alta taxa de morbidade e mortalidade e falta de consenso internacional sobre a melhor antibioticoterapia a ser administrada, a PIOA em recém-nascidos e crianças continua sendo um grande desafio. Seu diagnóstico deve ser realizado com brevidade, buscando evitar a ocorrência de sequelas como o encurtamento de membros ou óbito.
Cytotoxicity of curcumin-loaded magnetic nanoparticles against normal and cancer cells as a breast cancer drug delivery system
Authors: Alnooj Ali Mollaie Ghanat , Ghobadi Melika , Mousavi-Khattat Mohammad , Zohrabi Dina , Sekhavati Mohammad , Zarrabi Ali 
Published: November 2022

Recently, therapeutic applications of modified magnetic nanoparticles have attracted the attention of many researchers. The reason is the ability to develop nano drugs as cancer treatment agents. For this purpose, these particles must have a tiny size, intrinsic magnetic properties, imaging effectiveness, the ability to target the drug, and high drug absorption. Although studies have been performed on the anti-cancer properties of curcumin/nanoparticles, no comprehensive research has been performed to evaluate its anti-cancer and the normal cell toxicity of this drug system for breast cancer treatment. This study designed a curcumin-loaded MNPs (MNPs@CUR) formulation to accomplish these unique features. Using the diffusion process, chemical precipitation was used to make MNPs, which were then loaded with curcumin (CUR). Transmission electron microscopy (TEM) was used to study the morphology and size of MNP-CUR. The fabricated MNPs had spherical shapes with an average length of 23.22 nm. The presence of curcumin on the surface of MNPs was approved using Fourier transform infrared (FTIR) analysis. The X-ray diffraction (XRD) diffractogram confirmed the face cubic center (fcc) character of MNPs. After 24 hours of incubation with 4t1 breast cancer cells, MNPs@CUR anticancer effects were evaluated. MNPs@CUR displayed a concentration-dependent preference for applying anticancer effects on 4t1cells (IC50=108 µg/ml). Separated in vivo anti-tumor studies of coated/naked nanoparticles and curcumin also demonstrated that MNPs@CUR eliminated tumor mass. The cytotoxicity and genotoxicity against normal peripheral blood mononuclear cells (PBMC) were also measured by 2,5-diphenyl-2H-tetrazolium bromide (MTT) electrophoresis DNA digestion methods respectively for MNPs@CUR and naked MNPs. Cytotoxicity was demonstrated at high concentrations of MNP@CUR (991 µg/ml), while naked nanoparticles showed approximately no toxicity and neither had genotoxicity.
Two Example GRBs Where Fermi LAT “Extended” Data Gives a Better Photon List than “Photon”
Authors: Aldrich E. Casey , Mukherjee Oindabi , Nemiroff Robert J. 
Published: November 2022

Abstract
When analyzing Fermi LAT data for temporally contained events like gamma-ray bursts (GRBs), the best data type for analyses is “Extended,” not “Photon.” Although this is already recommended by the online Fermi website, it is easy to overlook and can lead to inferior analyses. Most extended “events” that are temporally and angularly consistent with GRBs are probably photons. While preparing GRB data for other research projects, the authors encountered this counter-intuitive fact several times. The data from two GRBs are presented with a simple analysis as a demonstration.
Complementary Mass Spectral Analysis of Isomeric O-bearing Organic Compounds and Fragmentation Differences through Analog Techniques for Spaceborne Mass Spectrometers
Authors: Khawaja Nozair , Hillier Jon , Klenner Fabian , Nölle Lenz , Zou Zenghui , Napoleoni Maryse , Reviol Rene , Postberg Frank 
Published: November 2022

Abstract
Mass spectrometers on board spacecraft typically use either impact ionization or electron ionization (EI) as ion sources. Understanding the similarities and differences in the spectral signatures and fragmentation patterns produced by different techniques in mass spectrometry could elucidate the composition of organic compounds. Here we present a comparison between the mass spectra obtained through laser-induced liquid beam ion desorption (LILBID; proven to simulate the impact ionization mass spectra of ice grains) and EI mass spectra of pairs of low-mass, isomeric aldehydes and ketones. Our comparison confirms that EI produces more fragmentation of carbonyl compounds, particularly aldehydes, than LILBID. We find protonated molecular ions [M+H]+ in LILBID but molecular ions [M]+ in EI spectra. From the evaluated species, LILBID generally produces oxygen-carrying fragment ions (e.g., [CHO]+ and [C2H3O]+) in the mass ranges 26–30 and 39–44 u, while in EI, most ions in these ranges correspond to hydrocarbon fragments. The LILBID spectra additionally show mostly protonated oxygen-bearing fragments [CH3O]+ and [C2H5O]+ at m/z 31 and 45, less commonly observed in EI spectra. We observe a decrease in the relative intensities of cation fragment mass lines between m/z 26 and 33 and an increase between m/z 39 and 45, with an increasing carbon number for ketones and aldehydes with LILBID and EI, respectively. Our study provides a basis for complementary compositional analysis to identify the structural properties of organic species in a space environment using different spaceborne mass spectrometers (e.g., SUrface Dust Analyzer and MAss Spectrometer for Planetary EXploration) on board NASA’s future Europa Clipper space mission.
Topical Losartan for Treating Corneal Fibrosis (Haze): First Clinical Experience
Authors: Pereira-Souza Amanda Luiza , Ambrósio Renato , Bandeira Francisco , Salomão Marcella Q. , Souza Lima Acacio , Wilson Steven E. 
Published: November 2022

PURPOSE:
To report the first clinical experience with topical losartan for treating a case of severe corneal haze after complicated laser in situ keratomileusis (LASIK).

METHODS:
A 36-year-old woman presented with corneal haze in the left eye after femtosecond laser–assisted LASIK. The left eye had flap dislocation and significant striae, which had been re-lifted. Uncorrected distance visual acuity (UDVA) was 20/200 and corrected distance visual acuity was 20/30 in the left eye at the first presentation, 52 days after the first procedure. A dense layer of subepithelial opacity (haze) was noted in the left cornea. The patient elected to start the off-label treatment with topical losartan 0.8 mg/mL six times per day.

RESULTS:
Four and one-half months after initiating topical losartan, UDVA improved to 20/30 and CDVA improved to 20/25 in the left eye. A significant reduction of corneal haze was observed at the slit lamp and using Scheimpflug corneal tomography (Pentacam AXL; Oculus Optikgeräte GmbH) and anterior segment optical coherence tomography (Revo NX 130; Optopol).

CONCLUSIONS:
Losartan is an inhibitor of transforming growth factor-β signaling. Topical treatment is promising to treat corneal haze formation after corneal injuries, chemical burns, and surgeries. Further clinical studies are needed to optimize losartan dosages and treatment durations.

[
J Refract Surg
. 2022;38(11):741–746.]
Travail du laiton et production de mforowa parmi les Akan de la côte du Ghana du xviie au xxe siècle
Authors: DeCorse Christopher R. 
Published: November 2022

Cet article traite de la fabrication et de la datation des ornements, outils et boites en laiton produits par les Akan dans les régions côtières du Ghana, en particulier les mforowa (sing. forowa), récipients en feuilles de laiton spécifiques utilisés pour y conserver le beurre de karité et qui sont associés à des rituels mortuaires. Les fouilles archéologiques ont permis de retrouver une variété d’artefacts fabriqués localement à partir de laiton européen importé, souvent en étroite association avec des objets de traite européens. Comme les gammes de production de nombreuses manufactures européennes sont connues et peuvent être bien circonscrites dans le temps – souvent à quelques décennies près –, les marchandises de traite offrent un moyen de dater précisément les artefacts qui leur sont associés et de manière plus assurée que ce qui est souvent possible pour les sites archéologiques africains des 500 dernières années. Cet affinage chronologique apporte un élément nouveau sur les traditions de travail des alliages de cuivre parmi les Akan côtiers, en particulier l’utilisation et la réutilisation du laiton importé. Cet article passe en revue les connaissances actuelles sur les origines de la métallurgie et la transformation du métal dans la région côtière du Ghana, et sur le développement du travail du laiton avec l’avènement du commerce européen. Les données archéologiques provenant de la ville africaine d’Elmina suggèrent que la production de mforowa a débuté au xviie siècle et que ses origines stylistiques trouvent leurs racines dans la tradition antérieure des nkuduo (sing. kuduo) en laiton coulé. Le contexte des découvertes archéologiques fournit également un aperçu des cadres culturels dans lesquels les mforowa ont été utilisés.
Deux millénaires ou deux siècles de constructions mégalithiques au Sénégal et en Gambie ? Nouvelles dates pour Wanar et révision des contextes archéologiques
Authors: Laporte Luc , Lefèvre Jean-Claude , Ndiaye Matar , Oberlin Christine , Delvoye Adrien , Stern Mathilde , Faye Abdoul Kader , Ballouche Aziz , Cros Jean-Paul , Djouad Selim , Quesnel Laurent 
Published: November 2022

Les mégalithes du Sénégal et de la Gambie comptent près de 30 000 pierres dressées qui ont été répertoriées sur une superficie d’environ 30 000 km². La toute première date radiocarbone associée aux mégalithes du Sénégal et de la Gambie a été publiée en 1965. La plupart des dates radiocarbone obtenues depuis lors concernent la partie la plus occidentale du mégalithisme sénégambien. Plus de 28 dates supplémentaires, pour la seule nécropole de Wanar (Sénégal), peuvent désormais être ajoutées aux 25 dates précédemment disponibles. Des modèles bayésiens, intégrant les contraintes stratigraphiques propres à chaque séquence pour chacun des monuments étudiés, indépendamment les uns des autres, nous permettent de préciser ces données, et de proposer un scénario historique. Elles illustrent une séquence régionale de peuplement sur plus de deux millénaires, alors que la construction des cercles de pierres dressées pourrait ne pas avoir duré plus de 200 à 300 ans. Deux dates radiocarbone sur des dents humaines fixent le décès des personnes inhumées au cours des xie ou xiie siècles AD.
Panal que cela su oro: (auto)censura, traducción, cartas y versos de amor de Gabriela Mistral a Doris Dana y a Paulita Brook
Authors: Madrigal Elena , Bermúdez Callejas Sulemi 
Published: November 2022

A partir de una lectura feminista y queer, analizamos diversos ethos escriturales de Gabriela Mistral, que se presentan en tres instancias: sus diarios, el epistolario amoroso que sostuvo con Doris Dana y el poema “La dichosa”, dedicado a Paulita Brook. Este acercamiento revela un yo multifacético, oscilante entre su prestigio público y un lesbianismo en consecuencia disidente, alejado del escándalo. En consonancia con los nuevos estudios mistralianos, proponemos tres perspectivas para el estudio de su ethos: su configuración icónica como defensora de los derechos de las mujeres, el fenómeno de la (auto) censura, así como la relectura de una composición poética. Al sumar algunos hitos biográficos y detalles contextuales, sostenemos que la admisión de la orientación sexual de Mistral posibilita interpretar sus escritos de manera novedosa así como entender la parcialidad de las traducciones de su obra al inglés y la tardía publicación de su obra completa, a contracorriente de la insistencia aún vigente de interpretaciones reduccionistas.