bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of clinical and subclinical endometritis impacts on the reproductive performance and milk production of dairy cows in Brazilian herds
Authors: Paiano Renan Braga , Bonilla Jeannine , Pugliesi Guilherme , Moreno Andrea Micke , Baruselli Pietro Sampaio 
Published: December 2022

AbstractClinical endometritis (CE) and subclinical endometritis (SE) are two of the main uterine diseases in dairy cows during the puerperium period that can directly affect milk production and fertility in dairy herds. The first objective of this study was to investigate the effects of the CE and SE on the subsequent reproductive performance and milk production of dairy cows in Brazilian herds, and the second objective was to evaluate the reproductive performance and milk production of dairy cows according to the positive or negative isolation of bacteria in the uterine environment. A total of 279 lactating Holstein dairy cows (28–33 days in milk) from six commercial farms were studied. These were classified into three groups: healthy cows (without CE and SE, n = 161), cows with CE (vaginal discharge score = 3 and ≥18% PMNL, n = 83) and cows with SE (absence of signs of CE and >18% PMNL, n = 35). According to the presence of bacteria isolated from the uterine environment, the animals were classified as healthy cows (n = 161), CE cows with positive (n = 68) and negative (n = 15) bacterial isolation; and SE cows with positive (n = 21) and negative (n = 14) bacterial isolation. Cows with CE (20.5%) and SE (31.4%) had a lower (p < .05) conception rate at first AI than healthy cows (47.8%). Furthermore, both cows with CE (3.1) and SE (2.8) needed more service to become pregnant than healthy cows (1.7) and more days to be pregnant (50.3 days in CE and 43.1 days in SE than healthy group; p < .001). Cows with CE (23.8 kg) and SE (23.7 kg) produced less milk than healthy cows on the day of sampling (28.2 kg); however, milk production during 305 DIM of cows with CE and SE was not impaired when compared to healthy cows. The logistic regression showed that parity, body condition score, 305 days milk production, last calving (eutocia or dystocia), twin birth and stillbirth were not associated with the incidence of CE and SE. In addition, we highlight that cows with CE and SE, but with negative bacteria isolation, did not have reproductive performance and milk production impaired during the postpartum period. These results support that the use of antibiotics would not be beneficial in these cows, contributing to the strategic and rational use of antibiotic therapy on dairy farms.
The role of perceived risk on dishonest decision making during a pandemic
Authors: Dawson Ian G. J. , Hanoch Yaniv M. 
Published: December 2022

AbstractThe COVID‐19 pandemic presented serious risks to the health and financial wellbeing of millions of people across the world. While many individuals adapted to these challenges through a variety of prosocial and protective behaviors (e.g., social distancing, working from home), many others also engaged in dishonest behaviors (e.g., lying to obtain vaccines or furlough payments). Hence, the COVID‐19 pandemic provided a unique context in which to obtain a better understanding of the relationship between risk and dishonesty. Across three preregistered studies, we assessed whether objective risk and perceived risk influenced the decision to behave dishonestly in order to gain access to vaccines and furlough payments during a pandemic. We also assessed the extent to which such dishonesty was deterred by the probability of the dishonesty being detected. We found that heightened health risk perceptions were positively related with lying to obtain a vaccine (Studies 1 and 2), but found no evidence of the same relationship between financial risk perceptions and lying to access furlough payments (Study 2). We also found that the probability of dishonesty being detected had a negative relationship with dishonest behavior (Study 3). In addition, across the three studies, we found that (i) dishonesty was consistently evident in approximately one‐third of all of our samples, and (ii) greater dishonesty was associated with older age. We discuss how our findings could be utilized by policy makers to better deter and detect dishonest behaviors during future similar crises.
Seeing beyond the spikes: reconstructing the complete spatiotemporal membrane potential distribution from paired intra‐ and extracellular recordings
Authors: Meszéna Domokos , Barlay Anna , Boldog Péter , Furuglyás Kristóf , Cserpán Dorottya , Wittner Lucia , Ulbert István , Somogyvári Zoltán 
Published: December 2022

AbstractAlthough electrophysiologists have been recording intracellular neural activity routinely ever since the ground‐breaking work of Hodgkin and Huxley, and extracellular multichannel electrodes have also been used frequently and extensively, a practical experimental method to track changes in membrane potential along a complete single neuron is still lacking. Instead of obtaining multiple intracellular measurements on the same neuron, we propose an alternative method by combining single‐channel somatic patch‐clamp and multichannel extracellular potential recordings. In this work, we show that it is possible to reconstruct the complete spatiotemporal distribution of the membrane potential of a single neuron with the spatial resolution of an extracellular probe during action potential generation. Moreover, the reconstruction of the membrane potential allows us to distinguish between the two major but previously hidden components of the current source density (CSD) distribution: the resistive and the capacitive currents. This distinction provides a clue to the clear interpretation of the CSD analysis, because the resistive component corresponds to transmembrane ionic currents (all the synaptic, voltage‐sensitive and passive currents), whereas capacitive currents are considered to be the main contributors of counter‐currents. We validate our model‐based reconstruction approach on simulations and demonstrate its application to experimental data obtained in vitro via paired extracellular and intracellular recordings from a single pyramidal cell of the rat hippocampus. In perspective, the estimation of the spatial distribution of resistive membrane currents makes it possible to distiguish between active and passive sinks and sources of the CSD map and the localization of the synaptic input currents, which make the neuron fire.
imageKey points
A new computational method is introduced to calculate the unbiased current source density distribution on a single neuron with known morphology.
The relationship between extracellular and intracellular electric potential is determined via mathematical formalism, and a new reconstruction method is applied to reveal the full spatiotemporal distribution of the membrane potential and the resistive and capacitive current components.
The new reconstruction method was validated on simulations.
Simultaneous and colocalized whole‐cell patch‐clamp and multichannel silicon probe recordings were performed from the same pyramidal neuron in the rat hippocampal CA1 region, in vitro.
The method was applied in experimental measurements and returned precise and distinctive characteristics of various intracellular phenomena, such as action potential generation, signal back‐propagation and the initial dendritic depolarization preceding the somatic action potential.
La cobertura de incapacidad total y permanente a la luz de la normativa costarricense – una propuesta de estandarización
Authors: Breedy Arguedas Said , Moreno Arroyo Andrea 
Published: December 2022

La cobertura de incapacidad total y permanente comprende dentro de la configuración del siniestro varios elementos que en su conjunto obligan a la entidad aseguradora a la indemnización. Tomando como base la legislación costarricense, se analiza la configuración del siniestro para los seguros de accidentes e incapacidad, su delimitación de cobertura, periodo de ocurrencia, la limitación de las preexistencias y factores como la disputabilidad, todas expresamente reguladas en la Ley Reguladora del Contrato de Seguro (Ley 8956) para luego constatar que existen algunas diferencias en los condicionados generales respecto a lo que consideramos la ideal aproximación respecto a la interpretación de las normas. Se aborda también la teoría de la causalidad adecuada a efectos de confirmar que los elementos evento (accidente o enfermedad) que causa lesión con algún grado de incapacidad y la declaratoria de incapacidad total y permanente deben realizarse en una ventana de tiempo determinada para que se configure el siniestro.
On the First-Order Optimization Methods in Deep Image Prior
Authors: Cascarano Pasquale , Franchini Giorgia , Porta Federica , Sebastiani Andrea 
Published: December 2022

Abstract
Deep learning methods have state-of-the-art performances in many image restoration tasks. Their effectiveness is mostly related to the size of the dataset used for the training. Deep image prior (DIP) is an energy-function framework which eliminates the dependency on the training set, by considering the structure of a neural network as an handcrafted prior offering high impedance to noise and low impedance to signal. In this paper, we analyze and compare the use of different optimization schemes inside the DIP framework for the denoising task.
Rewiring the logic board of IFN signaling
Authors: MacMicking John D. 
Published: December 2022

Interferons (IFNs) activate cell-autonomous immunity to combat infection and control inflammation. In this issue of
Science Signaling
, Boccuni
et al.
reveal how macrophages incorporate stress signals through the p38 MAPK pathway to enhance IFN-induced responses against intracellular pathogens.
First Synthesis of 2-Amino-5-hydroxy-4H-chromene-3-carbonitriles from 4-(2-Pyridylazo)resorcinol
Authors: Dotsenko V. V. , Varzieva E. A. , Buriy D. S. , Aksenov N. A. , Aksenova I. V. 
Published: December 2022

Abstract
4-(2-Pyridylazo)resorcinol (PAR) sodium salt reacts with aromatic aldehydes and malononitrile in aqueous ethanol to form 2-amino-4-aryl-5-hydroxy-6-(2-pyridylazo)-4H-chromene-3-carbonitriles.
Diabetes-related shame among people with type 2 diabetes: an internet-based cross-sectional study
Authors: Inagaki Satoshi , Matsuda Tomokazu , Muramae Naokazu , Abe Kozue , Kato Kenji 
Published: December 2022

IntroductionEmerging evidence suggests that diabetes stigma and negative emotions associated with it may impair the quality of life of people with diabetes. Among these psychological distresses, shame is considered the most distressing of all human emotional experiences and may be a condition to which diabetes clinicians should pay attention. This epidemiological study focused on diabetes-related shame and aimed to determine the prevalence of diabetes-related shame, its factors, and its association with psychological indicators.Research design and methodsA cross-sectional online survey was conducted among people with type 2 diabetes preregistered with a research firm. The questionnaire included experience of diabetes-related shame and demographic data such as age, clinical characteristic measures such as hemoglobin A1c (HbA1c), and psychological indicators, including the WHO Five Well-Being Index (WHO-5) and Problem Areas In Diabetes-5 (PAID-5). Differences in each indicator between people with diabetes who experienced shame and those who did not were analyzed with the unpaired t-test. As supplemental analysis, binomial logistic regression analysis was used to identify factors associated with the prevalence of diabetes-related shame.ResultsOf the 510 participants, 32.9% experienced diabetes-related shame and 17.5% concealed their disease from colleagues or friends. Those who had experienced diabetes-related shame showed significantly lower WHO-5 and higher PAID-5 scores (p<0.001). However, no significant difference was found in HbA1c (p=0.36). Binomial logistic regression revealed that women, young adults, those without a college degree, those with low self-efficacy, and those with a strong sense of financial burden or external pressure were at higher risk of experiencing diabetes-related shame.ConclusionsAmong people with type 2 diabetes mellitus, diabetes-related shame was associated with diabetes-specific emotional distress and low psychological well-being. Further research and care development are needed to address diabetes-related shame and improve the quality of life of people with diabetes.
Efficacy of periodontal soft tissue augmentation prior to orthodontic treatment on preventing gingival recession: study protocol for a randomised controlled trial
Authors: Chen Jing , Lv Jiashu , Zhang Fan , Zhang Wei , Wang Yuhui , Xu Yichen , Pan Yichen , Li Qiang 
Published: December 2022

IntroductionIn adult patients with thin phenotype, gingival recession is obvious in the mandibular incisors after a large amount of lingual tooth movement. A systematic review indicated that soft tissue augmentation before orthodontic treatment might yield satisfactory results with respect to the progression of gingival recession. However, the studies included had a low-to-moderate level of evidence. This study was designed to investigate the efficacy of soft tissue augmentation prior to orthodontic treatment on the prevention of gingival recession.Method and analysisThis is a single-centre, single-blind, randomised controlled, double-armed parallel group comparison trial. This study was initiated in December 2021 and end in December 2025 (anticipated). Patients with mild crowding in the lower arch and a thin gingival type was enrolled and randomly assigned in a 1:1 ratio to either group A (having soft tissue augmentation prior to orthodontic treatment) or group B (having orthodontic treatment only). The planned number of enrolled patients was 48 (24 patients × 2 groups). The primary endpoint was the mean change in recession of the gingival margin. Secondary endpoints included the probing depth, gingival phenotype, frequency of complete root coverage, gingival thickness, width of the keratinised gingiva, clinical attachment level, gingival recession class, full-mouth plaque score, alveolar bone thickness in the faciolingual dimension of the lower anterior teeth and lower incisor inclination.Ethics and disseminationThe study protocol was approved by the Ethical Committee of the Shanghai Stomatological Hospital (certificate number (2021)016). The study was conducted in accordance with the Declaration of Helsinki, the Clinical Trials Act and other current legal regulations in China. Written informed consent was obtained from all the participants. The results of this study will be reported in journal publications.Trial registration numberChiCTR2100050892.
Implementation of effective blended periconception lifestyle care in a tertiary hospital in the Netherlands: a cross-sectional study on determinants and patient satisfaction
Authors: van der Windt Melissa , Schoenmakers Sam , van der Kleij Rianne MJJ , van Rossem Lenie , Steegers-Theunissen Régine PM 
Published: December 2022

ObjectiveTo identify implementation determinants of blended periconception lifestyle care, and to evaluate patient satisfaction.DesignCross-sectional study.SettingThe outpatient clinic of the department of Obstetrics and Gynaecology of the Erasmus MC.ParticipantsImplementation part: counsellors providing blended periconception lifestyle care. Patient satisfaction part: women who received blended periconception lifestyle care.MethodsBlended periconception lifestyle care, including face-to-face counselling and 26 weeks of lifestyle coaching via the online platform ‘Smarter Pregnancy’, was implemented between June–December 2018. The Measurement Instrument for Determinants of Innovations questionnaire was used as input for the consolidated framework for implementation research to assess determinants of implementation. To evaluate patient satisfaction, patients receiving lifestyle care filled out an evaluation questionnaire, including questions on the needs for lifestyle counselling, information provision during counselling, and motivation and lifestyle change after counselling.Primary and secondary outcome measuresIdentification of implementation determinants and the level of patient satisfaction.ResultsFacilitators were reported in the implementation domains ‘characteristics of the intervention’ and ‘characteristics of the individuals’. Barriers were in the implementation domains ‘inner setting’ and ‘implementation process’. Regarding patient satisfaction on nutrition counselling, 31% of the respondents wanted information prior to the counselling session, 22% received new information after consultation, 51% got motivated to change and 40% changed their nutritional behaviour.ConclusionsA considerable number of patients improved lifestyle after counselling, although, a relatively small number wanted lifestyle counselling prior to consultation.This study underlines the importance of implementation science and the information it provides for improving the implementation process.
Only eye study 3 (OnES 3): a qualitative study into how surgeons approach surgery in patients with only one seeing eye
Authors: Whyte Jonathan P , Lee Graham , Jones Lee , Shah Peter 
Published: December 2022

ObjectivePerforming surgery on an ‘only eye’ patient is considered high stakes. The purpose of this study is to explore the process of only eye surgery from the perspective of ophthalmic surgeons and improve both patient and surgeon experience.Design, setting and participantsA cohort of 76 Australian consultant ophthalmologists, divided into three focus groups, were recruited via online webinar to participate in a guided focus group discussion about only eye surgery. Qualitative data regarding participant experience of performing only eye surgery were collected in audio and text form. Thematic analysis was conducted to identify patterns in the data.Main outcome measureIdentification of themes relevant to only eye surgery.ResultsFive overarching themes relevant to only eye surgery were identified: (1) differences in the surgical decision-making process; (2) differences in the approach to consent, (3) implementation of additional risk reduction strategies, (4) value of having colleagues to discuss and plan surgery with and (5) psychological challenges. A divergent theme was identified: (6) that all surgery, only eye or not, should be treated the same.ConclusionsThis study identifies challenges associated with clinical management of only eye patients across their surgical journey. A conceptual framework to guide surgeons when managing only eye patients is provided which has potential to promote a more unified approach to treating this high-stakes cohort.
Poverty, education and health insurance coverage among women of reproductive ages in the Democratic Republic of the Congo: a cross-sectional and multilevel analysis
Authors: Tsala Dimbuene Zacharie , Muanza Nzuzi Raphaël , Nzita Kikhela Paul-Denis 
Published: December 2022

ObjectiveTo investigate inequalities of health insurance coverage (outcome) at subnational level, and the effects of education and poverty on the outcome.DesignSecondary analysis of Demographic and Health Surveys. The outcome variable was health insurance ownership.SettingThe Democratic Republic of the Congo.SubjectsWomen aged 15–49 years (n=18 827).ResultsFindings indicated significant spatial variations of the health insurance ownership which ranged from 1.2% in Bandundu and Kasaï Oriental to 15.5% in Kinshasa the Capital City. Furthermore, findings showed that an additional year of women education increased by 10% the chance of health insurance ownership (adjusted OR, AOR 1.098; 95% CI 1.065 to 1.132). Finally, living in better-off households increased by 150% the chance of owing a health insurance (AOR 2.501; 95% CI 1.620 to 3.860) compared with women living in poor households.ConclusionsGiven the low levels of health insurance coverage, the Democratic Republic of the Congo will not reach the Sustainable Development Goal 3, aimed at improving maternal and child health unless a serious programmatic health shift is undertaken in the country to tackle inequalities among poor and uneducated women via universal health coverage.
Examining interprofessional collaboration in oncogenetic service delivery models for hereditary cancers: a scoping review protocol
Authors: Espinoza Moya Maria Eugenia , Guertin Jason Robert , Dorval Michel , Lapointe Julie , Bouchard Karine , Nabi Hermann , Laberge Maude 
Published: December 2022

IntroductionIn a context of limited genetic specialists, collaborative models have been proposed to ensure timely access to high quality oncogenetic services for individuals with inherited cancer susceptibility. Yet, extensive variability in the terminology used and lack of a clear understanding of how interprofessional collaboration is operationalised and evaluated currently constrains the development of a robust evidence base on the value of different approaches used to optimise access to these services. To fill in this knowledge gap, this scoping review aims to systematically unpack the nature and extent of collaboration proposed by these interventions, and synthesise the evidence available on their implementation, effectiveness and economic impact.Methods and analysisFollowing the Joanna Briggs Institute guidelines for scoping reviews, a comprehensive literature search will be conducted to identify peer-reviewed and grey literature on collaborative models used for adult patients with, or at increased risk of, hereditary breast, ovarian, colorectal and prostate cancers. An initial search was developed for Medline, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane and Web of Science on 13 June 2022 and will be complemented by searches in Google and relevant websites. Documents describing either the theory of change, planning, implementation and/or evaluation of these interventions will be considered for inclusion. Results will be summarised descriptively and used to compare relevant model characteristics and synthesise evidence available on their implementation, effectiveness and economic impact. This process is expected to guide the development of a definition and typology of collaborative models in oncogenetics that could help strengthen the knowledge base on these interventions. Moreover, because we will be mapping the existing evidence on collaborative models in oncogenetics, the proposed review will help us identify areas where additional research might be needed.Ethics and disseminationThis research does not require ethics approval. Results from this review will be disseminated through peer-reviewed articles and conferences.