bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coparenting‐focused preventive intervention reduces postnatal maternal BMI and buffers impact of cortisol
Authors: Moran Lisa J. , Lee Jin‐Kyung , Jones Damon , Fronberg Kaitlin , Feinberg Mark E. 
Published: July 2022

AbstractObjectiveThe postpartum period is a key life stage, contributing to increased maternal obesity risk. Current lifestyle interventions do not consider the role of a woman's partner in reducing stress and supporting lifestyle change. The objective of this study was to assess the effect of an intervention that seeks to enhance coparenting relationship quality on maternal BMI from before conception to 12 months post partum and whether the intervention moderated the association of changes in cortisol and BMI.MethodsA randomized controlled trial was used to assess an intervention (eight classes: four during and four following pregnancy) focusing on enhancing couple coparenting relationships during pregnancy and post partum (n = 57) compared with standard care (n = 53).ResultsThe main outcome measures were changes in maternal BMI and cortisol. There was a smaller increase in BMI for mothers in intervention compared with control groups (mean [SE], −1.03 [0.42] kg/m2, p = 0.015). There was an interaction between intervention status and cortisol change predicting BMI change (p = 0.026), such that cortisol change significantly predicted BMI change among mothers in the control (p = 0.049) but not the intervention groups (p = 0.204).ConclusionsA coparenting intervention improved maternal postpartum BMI, with this effect potentially related to ameliorating the negative effect of stress, as measured by cortisol, on BMI. The role of enhanced coparenting in improving maternal anthropometry warrants urgent attention.
Childhood acute lymphoblastic leukemia: Four years evaluation of protocols 2013 and 2016 in a single center in Indonesia, a lower‐middle‐income country
Authors: Sutaryo Sutaryo , Widjajanto Pudjo Hagung , Mulatsih Sri , Ardianto Bambang , Pangarso Alexandra Widita Swipratami , Supriyadi Eddy , Purwanto Ignatius , Adelin Claudia Priska , Lestari Rahmadani Puji , Sagoro Lintang , Christian Scholastika Dita , Sabrina Dea Sella , Verena Natasha , Kors Wijnanda Adriana , Kaspers Gertjan J. L. , Veerman Anjo J. P. 
Published: July 2022

AbstractBackgroundThe prognosis of childhood acute lymphoblastic leukemia (ALL) in Indonesia, a lower‐middle‐income country (LMIC), is lower than in high income countries (HICs). The Indonesian ALL2013 protocol resulted in too many toxic deaths (21%) and abandonments (11%). Therefore, we drafted an adapted protocol, ALL2016. Main changes: no anthracyclines in standard risk (SR), prednisone replaced dexamethasone at induction in high risk (HR), and anthracyclines and cyclophosphamide were rescheduled in HR.ProcedurePatients (aged: 1–18 years) were stratified into SR and HR. HR was defined as age over 10 years, leucocyte count over 50 × 109/L, central nervous system (CNS) involvement, mediastinal mass, T‐cell phenotype, testicular involvement, or poor prednisone response.ResultsALL2013 included 174 patients (106 SR and 68 HR) and ALL2016 188 (91 SR and 97 HR). Although the number of HR patients was significantly higher in ALL2016 (51.6% vs. 39.1%; p = .017), the outcome of ALL2016 improved over ALL2013 (4‐year‐probable overall survival (pOS) 60.1% vs. 50.0%; p = .042 and 4‐year‐probable event‐free survival (pEFS) 49.5% vs. 36.8%; p = .018). ALL2016 showed a nonsignificant advantage for SR patients (4‐year‐pEFS 56.0% vs. 47.2%; p = .220 and 4‐year‐pOS 70.3% vs. 61.3%; p = .166), but less toxic deaths (7% vs. 20%; p = .011). In HR group, the outcomes were significantly better in ALL2016 (4‐year‐pEFS 43.3% vs. 20.6%; p = .004; 4‐year‐pOS 50.5% vs. 32.4%; p = .014) especially due to less relapses (31% vs. 62%; p = .001). Isolated CNS relapses went down from 18 to 8% in HR (p = .010) and 11 to 5% in SR (p = .474). Both SR and HR showed lower numbers of abandonment in ALL2016 (6% vs. 14%; p = .039).ConclusionsOverall ALL2016 results improved over ALL2013. Modest changes in protocol resulted in less initial toxicity and abandonments.
Pediatric hematology providers’ contraceptive practices for female adolescents and young adults with sickle cell disease: A national survey
Authors: Askew Megan A. , Smaldone Arlene M. , Gold Melanie A. , Smith‐Whitley Kim , Strouse John J. , Jin Zhezhen , Green Nancy S. 
Published: July 2022

AbstractBackgroundAdolescent and young adult (AYA) women with sickle cell disease (SCD) have increased pregnancy‐related health risks and are prescribed potentially teratogenic medications, yet limited data are available regarding pediatric SCD provider contraceptive practices. We aimed to assess pediatric hematology providers’ beliefs, practices, motivators, and barriers for providing contraceptive care to female AYAs with SCD.MethodsGuided by the Health Belief Model (HBM), we developed a 25‐question, web‐based survey to assess practices. Survey links were distributed nationwide to pediatric SCD and/or general hematology providers through their publicly available emails and by request to directors of U.S.‐accredited Pediatric Hematology‐Oncology fellowship programs for distribution to their SCD providers. Data analysis included descriptive statistics, chi‐square analysis, and logistic regression.ResultsOf 177 respondents, 160 surveys meeting inclusion criteria were analyzed. Most providers reported counseling (77.5%) and referring female AYA patients for contraception (90.8%), but fewer reported prescribing contraception (41.8%). Proportionally fewer trainees provided counseling compared with established providers (54% vs. 85%, p < .001), with a similar trend for prescribing (p = .05). Prescription practices did not differ significantly by provider beliefs regarding potential teratogenicity of hydroxyurea. Key motivators included patient request and disclosure of sexual activity. Key barriers included inadequate provider training, limited visit time, and perceived patient/parent interest.ConclusionProvider contraceptive practices for female AYAs with SCD varied, especially by provider status. Health beliefs regarding teratogenic potential of hydroxyurea did not correlate with contraceptive practices. Clinical guidelines, provider training, and patient/parent decision‐making tools may be tested to assess whether provider contraceptive practices could be improved.
Rivaroxaban treatment among children with cancer‐associated thromboembolism: Real‐world data
Authors: Barg Assaf Arie , Levy‐Mendelovich Sarina , Gilad Oded , Yacobovich Joanne , Tamarin Ilia , Budnik Ivan , Golan Hana , Toren Amos , Kenet Gili 
Published: July 2022

AbstractThis is the first study examining real‐life data of pediatric cancer patients treated with rivaroxaban. Children with thrombocytopenia and high bleeding risk were excluded from previous clinical trials. Data regarding the safety and efficacy of rivaroxaban in pediatric cancer‐associated thrombosis are scarce. Our case series included 16 children aged 7.5–17 years. Thrombus resolution rate in our study was comparable to results of previous studies. However, higher rates of thrombotic and bleeding complications were seen in our study as compared to previous reports, especially among patients with relapsed or refractory disease.
Thermal and acoustic properties of silane and hydrogen peroxide treated oil palm/bagasse fiber based biophenolic hybrid composites
Authors: Ramlee Nor Azlina , Jawaid Mohammad , Zainudin Edi Syams , Yamani Shaikh Abdul Karim , Alamery Salman , Fouad Hassan , Santulli Carlo , Sarmin Siti Noorbaini 
Published: July 2022

AbstractThe consequence of 2% v/v silane‐treated and 4% v/v H2O2‐treated upon thermal and acoustic behavior of hybrid oil palm EFB (OPEFB) and sorghum stalks bagasse fiber (SCB) reinforced phenolic composites for wall thermal insulation application is discussed in this paper. Hand lay‐up approach was adopted to manufacture plain and hybrid composites with diverse formulation ratios such as 70:30 (7OPEFB:3SCB), 50:50 (5OPEFB:5SCB), and 30:70 (3OPEFB:7SCB). The experimental samples were manufactured with a purpose density of 0.5 g/cm3. Plain and hybrid composites were investigated for thermal analysis and thermal conductivity testing. Impedance tubes were used for acoustic behavior analysis of composites. Hybridization of H2O2 treated HT 50:50 (5OPEFB:5SCB) showed greater thermal cohesion with a final residual of 58.69%, followed by hybridization of silane‐treated ST 50:50 (5OPEFB:5SCB) with a residual of 45.10%. This study looks at four distinct air gap thicknesses (0 mm, 10 mm, 20 mm, and 30 mm). The results reveal that silane‐treated ST 50:50 (5OPEFB:5SCB) hybrid composites and H2O2‐treated HT 50:50 (5OPEFB:5SCB) hybrid composites improved sound absorption coefficients more than 0.50. Thus, we concluded that thermal and sound absorption performances of hybrid composites from agro waste promise an environmentally friendly alternative solution in wall building material production.
Critical strain energy release rate of woven carbon/epoxy composites subjected to thermal cyclic loading
Authors: Sabaghi Mohammad , Taheri‐Behrooz Fathollah , Salamat‐Talab Mazaher 
Published: July 2022

AbstractIn the current study, experimental and numerical approaches were adopted to investigate the effect of thermal cyclic load on the delaminated beam behavior of woven carbon/epoxy laminated composites. For this purpose, composite specimens were prepared according to ASTM standard and subjected to 175 thermal cycles in the range of −30 to 60°C before conducting the mode I and mode II interlaminar fracture tests. Experimental results revealed that thermal cycles lead to a drop in maximum loading capacity of the delaminated beam as well as the interlaminar fracture toughness of the woven carbon/epoxy composites. The beam fracture toughness at initiation and propagation decreased by 8% and 12% under mode I loading and by 13.84% and 15.64% under mode II loading, respectively. In the numerical analysis, the cohesive zone model was utilized in order to predict the global response of the delaminated beams. The micro and scanning electron microscope images of fracture surfaces provide efficient insights into the identification of the main mechanisms contributing to decreasing fracture toughness under cyclic thermal load. These images show that specimens subjected to cyclic thermal load exhibited smoother surfaces, which could be due to weaker bonding between matrix and fibers after cyclic thermal loading.
Improving bonding strength of injection Overmolded composites
Authors: Akpınar Serkan , Metin Merve , Koçoğlu Hürol , Kodal Mehmet , Sezen Meltem , Özkoç Güralp , Altan M. Cengiz 
Published: July 2022

AbstractThe overmolding of short fiber reinforced polymer compounds onto continuous fiber reinforced composite substrates provides design flexibility and the ability to tailor stiffness, strength, and damage tolerance for structural applications. In this work, a novel molding approach that enhances the bonding strength by mechanical interlocking is presented. The effectiveness of the proposed approach was validated by characterization of the bonding strength between a short glass fiber PP (SGFPP) composite overmolded onto a continuous glass fiber reinforced PP (CGFRPP) prepreg. Enhancement of the bonding strength was achieved by judiciously drilling tapered holes on the CGFRPP substrate before molding, which facilitated better interlocking with the injection molded SGFPP composite. The overmolding of preheated composites with tapered holes yielded up to 60% improvement in bonding strength. In general, having multiple holes helped improve bonding up to certain hole diameter. Similarly, preheating of the substrate over a short time improved the interfacial adhesion, while extended preheating resulted in a reduction of bonding quality. SEM analysis of the fracture surfaces after the tensile debonding test revealed that the SGFPP filled the holes on the substrate during overmolding.
The Arabidopsis T‐DNA mutant SALK_008491 carries a 14‐kb deletion on chromosome 3 that provides rare insights into the plant response to dynamic light stress
Authors: Lopez Laura S. , Völkner Carsten , Day Philip M. , Lewis Chance M. , Lewis Chase L. , Schneider Dominik , Correa Galvis Viviana , Cruz Jeffrey A. , Armbruster Ute , Kramer David M. , Kunz Hans‐Henning 
Published: July 2022

AbstractIn nature, plants experience rapid changes in light intensity and quality throughout the day. To maximize growth, they have established molecular mechanisms to optimize photosynthetic output while protecting components of the light‐dependent reaction and CO2 fixation pathways. Plant phenotyping of mutant collections has become a powerful tool to unveil the genetic loci involved in environmental acclimation. Here, we describe the phenotyping of the transfer‐DNA (T‐DNA) insertion mutant line SALK_008491, previously known as nhd1‐1. Growth in a fluctuating light regime caused a loss in growth rate accompanied by a spike in photosystem (PS) II damage and increased non‐photochemical quenching (NPQ). Interestingly, an independent nhd1 null allele did not recapitulate the NPQ phenotype. Through bulk sequencing of a backcrossed segregating F2 pool, we identified an ~14‐kb large deletion on chromosome 3 (Chr3) in SALK_008491 affecting five genes upstream of NHD1. Besides NHD1, which encodes for a putative plastid Na+/H+ antiporter, the stromal NAD‐dependent D‐3‐phosphoglycerate dehydrogenase 3 (PGDH3) locus was eradicated. Although some changes in the SALK_008491 mutant's photosynthesis can be assigned to the loss of PGDH3, our follow‐up studies employing respective single mutants and complementation with overlapping transformation‐competent artificial chromosome (TAC) vectors reveal that the exacerbated fluctuating light sensitivity in SALK_008491 mutants result from the simultaneous loss of PGDH3 and NHD1. Altogether, the data obtained from this large deletion‐carrying mutant provide new and unintuitive insights into the molecular mechanisms that function to protect the photosynthetic machinery. Moreover, our study renews calls for caution when setting up reverse genetic studies using T‐DNA lines. Although second‐site insertions, indels, and SNPs have been reported before, large deletion surrounding the insertion site causes yet another problem. Nevertheless, as shown through this research, such unpredictable genetic events following T‐DNA mutagenesis can provide unintuitive insights that allow for understanding complex phenomena such as the plant acclimation to dynamic high light stress.
Multi‐omics analysis reveals expression complexity and functional diversity of mouse kinome
Authors: Huang Xin , Li Ling , Zhou Suiping , Kong Dehui , Luo Jie , Lu Lu , Xu Hai‐Ming , Wang Xusheng 
Published: July 2022

AbstractProtein kinases are a crucial component of signaling pathways involved in a wide range of cellular responses, including growth, proliferation, differentiation, and migration. Systematic investigation of protein kinases is critical to better understand phosphorylation‐mediated signaling pathways and may provide insights into the development of potential therapeutic drug targets. Here we perform a systems‐level analysis of the mouse kinome by analyzing multi‐omics data. We used bulk and single‐cell transcriptomic data from the C57BL/6J mouse strain to define tissue‐ and cell‐type‐specific expression of protein kinases, followed by investigating variations in sequence and expression between C57BL/6J and DBA/2J strains. We then profiled a deep brain phosphoproteome from C57BL/6J and DBA/2J strains as well as their reciprocal hybrids to infer the activity of the mouse kinome. Finally, we performed phenome‐wide association analysis using the BXD recombinant inbred (RI) mice (a cross between C57BL/6J and DBA/2J strains) to identify any associations between variants in protein kinases and phenotypes. Collectively, our study provides a comprehensive analysis of the mouse kinome by investigating genetic sequence variation, tissue‐specific expression patterns, and associations with downstream phenotypes.
Prospective observational study to evaluate the clinical and biological safety profile of pyronaridine–artesunate in a rural health district in Burkina Faso
Authors: Rouamba Toussaint , Sondo Paul , Yerbanga Isidore W. , Compaore Adelaide , Traore‐Coulibaly Maminata , Hien Franck S. , Diande Nassirou A. , Valea Innocent , Tahita Marc Christian , Baiden Rita , Binka Fred , Tinto Halidou 
Published: July 2022

AbstractThe assessment in real‐life conditions of the safety and efficacy of new antimalarial drugs is of greatest interest. This study aimed to monitor and evaluate both clinical and biological safety of pyronaridine‐artesunate (PA) in real‐life conditions in Burkina Faso's health system. This was a single‐arm, open‐label study, where patients attending Nanoro health facilities with uncomplicated malaria were consented to be part of a cohort event monitoring (CEM). At inclusion (day‐0), PA was administered orally once a day for 3 days. Patients spontaneous reported any clinical adverse events (AEs) occurring within 28 days following the treatment. Additionally, the study focused on AEs of special interest (AESI), namely clinical signs related to hepatotoxicity and increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST). A nested subset of patients with blood sample collection at day‐0 and day‐7 were monitored to investigate the effect of PA on biochemistry parameters. From September 2017 to October 2018, 2786 patients were treated with PA. About 97.8% (2720/2786) of patients did not report any AE. The most commonly reported events were respiratory, thoracic, and mediastinal disorders (8.3 per 1000), infections and infestations (7.9 per 1000), and gastrointestinal disorders (7.2 per 1000). No clinical or biological hepatotoxicity event related to PA was reported during the follow‐up. Changes in biochemistry parameters remained within laboratory reference ranges. The study showed that PA is a well‐tolerated drug and should be considered as a good option by malaria control programs in countries where existing first‐line antimalarial drugs are continuously threatened by the emergence of drug resistance.
Evaluating response‐adaptive randomization procedures for recurrent events and terminal event data using a composite endpoint
Authors: Mau Yu‐Lin , Su Pei‐Fang 
Published: July 2022

AbstractRecurrent event and terminal event data commonly arise in clinical and observational studies. To evaluate the efficacy of a treatment effect for both types of events, a composite endpoint has been used as a possible assessment, particularly when faced with high costs and a longer follow‐up study. To model recurrent event processes complicated by the existence of a terminal event, joint frailty modeling has been typically employed. In this study, the objective was to develop some target‐driven response adaptive randomization strategies using a composite endpoint based on joint frailty modeling. We first implemented a balanced randomized design and then investigated the response adaptive randomization. The former is intuitively first adopted while the latter is expected to be desirable and ethical in terms of allocating more subjects to the more effective treatment. The results show that the proposed procedures using a composite endpoint are capable of reducing the number of trial participants who receive inferior treatment while simultaneously reaching a desired optimal target as compared to a balanced randomized design. The R shiny application for calculating the sample size and allocation probabilities is also available. Finally, two clinical trials were used as pilot datasets to introduce the proposed procedures.
Gas source localization and mapping with mobile robots: A review
Authors: Francis Adam , Li Shuai , Griffiths Christian , Sienz Johann 
Published: July 2022

AbstractWithin the last couple of decades, there has been increasing research into the use of mobile robots for gas sensing applications. This has led to many different branches of research, most notably on the topics of gas distribution mapping and source localization. This paper aims to provide an up to date and comprehensive overview of the research on these topics for both controlled and uncontrolled environments with ground‐based or aerial robots. To complement other review papers, a greater focus is placed on recent probabilistic algorithms developed for both single robot and multirobot applications.
Application of DLLME‐SFO as a Green Analytical Tool for Determination of Trace Amounts of Cadmium and Lead in Vegetables and Fruits using FAAS: Optimization Using Box‐Behnken Design**
Authors: Mahmoudian Masoumeh , Sarrafi Amir Hossein Mohsen , Konoz Elaheh , Niazi Ali 
Published: July 2022

AbstractIn this study, dispersive liquid‐liquid microextraction method based on solidification of floating organic drop (DLLME‐SFO) was developed for the preconcentration of trace amount of Pb(II) and Cd(II) in vegetable and fruit extracts (DIW, Apple, Kiwi, Banana, Orange, Mint, Dill, Savory, and Thyme) and determination of these ions by flame atomic absorption spectroscopy (FAAS). The proposed method is based on the formation of an ion association Pb‐ 4‐(2‐thiazolylazo) resorcinol (TAR) ‐ zephiramine chloride (ZCl) and Cd‐4‐(2‐thiazolylazo) resorcinol (TAR) ‐ zephiramine chloride (ZCl) and then extraction of the resulting complex in micro‐droplets of the extraction solvent. Response surface methodology (RSM) based on the Box‐Behnken Design (BBD) was applied to optimize the experimental variables and evaluate the effect of factors. Optimal conditions were obtained with pH=6, 0.6 mL of the ligand solution 4‐(2‐thiazolylazo) resorcinol 0.2 %, 221 μL of 0.2 % zephiramine chloride, 130 μL of 1‐undecanol as solvent extraction, and 530 μL of acetonitrile. The linear range was 3.8‐200 and 1.0–160.0 μg L−1 with a coefficient of determination (R2) of 0.9976 and 0.9985 for Pb (II) and Cd(II), respectively. The limit of detection (LOD) was found to be 1.2 and 0.3 μg L−1 for Pb (II) and Cd(II), respectively. According to the results of market samples, the recovery (%) of the interday and intraday related to the Pb(II) were in the range of 94.67 % to 103.33 % and 95.33 % to 104.00 % for fruits and vegetables, respectively. Also, the relative standard deviation (RSD%) values of Pb(II) corresponding to the interday and intraday were found to be 1.52 % to 4.36 % and 2.15 % to 4.54 % for fruits and vegetables, respectively. In addition, the recoveries of Cd(II) were obtained 96.33 % to 104.00 % and 97.33 % to 103.33 % for fruits and vegetables, respectively. The RSD values of Cd(II) were 2.09 % to 4.19 % and 2.15 % to 4.54 % for fruits and vegetables, respectively. DLLME‐SFO uses an extraction solvent with lower toxicity instead of highly toxic solvents in other methods and high extraction recovery within a short period of time is possible.