bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing tailored theoretically informed goal-setting interventions for rehabilitation services: a co-design approach
Authors: Baker Amanda , Cornwell Petrea , Gustafsson Louise , Stewart Claire , Lannin Natasha A. 
Published: June 2022

Abstract
Background
Several active ingredients contribute to the purposes and mechanisms of goal-setting in rehabilitation. Active ingredients in the goal-setting process include, interdisciplinary teamworking, shared decision-making, having meaningful and specific goals, and including action planning, coping planning, feedback, and review. Clinicians have expressed barriers and enablers to implementing these active ingredients in rehabilitation teams. Interventions designed to improve goal-setting practices need to be tailored to address context specific barriers and enablers. Attempts to understand and enhance goal-setting practices in rehabilitation settings should be supported using theory, process models and determinant frameworks. Few studies have been undertaken to enhance goal-setting practices in varied case-mix rehabilitation settings.

Methods
This study is part of a larger program of research guided by the Knowledge to Action (KTA) framework. A multisite, participatory, codesign approach was used in five sites to address three stages of the KTA. (1) Focus groups were conducted to understand barriers and enablers to implementing goal-setting at each site. Following the focus groups three staff co-design workshops and one consumer workshop were run at each site to (2) adapt knowledge to local context, and to (3) select and tailor interventions to improve goal-setting practices. Focus groups were analysed using the Theoretical Domains Framework (TDF) and informed the selection of behaviour change techniques incorporated into the implementation plan.

Results
Barriers and enablers identified in this study were consistent with previous research. Clinicians lacked knowledge and understanding of the differences between a goal and an action plan often confusing both terms. Clinicians were unable to demonstrate an understanding of the importance of comprehensive action planning and review processes that extended beyond initial goal-setting. Interventions developed across the sites included staff training modules, a client held workbook, educational rehabilitation service flyers, interdisciplinary goal-based case conference templates, communication goal boards and a key worker model. Implementation plans were specifically established for each site.

Conclusions
Rehabilitation teams continue to struggle to incorporate a truly client-centred, interdisciplinary model of goal-setting in rehabilitation. Whilst clinicians continue to lack understanding of how they can use aspects of goal-setting to enhance client outcomes and autonomy in rehabilitation settings.
Evaluation of safety and anti-obesity effects of DWP16001 in naturally obese dogs
Authors: Rhee Beomseok , Mahbubur Rahman Md , Jin Changfan , Choi Ji-Soo , Lim Hyun-Woo , Huh Wan , Park Joon Seok , Han Jumi , Kim Sokho , Lee Youngwon , Park Jinho 
Published: June 2022

Abstract
Background
The aim of this study was to investigate the anti-obesity effects of DWP16001, a sodium-glucose cotransporter-2 (SGLT2 inhibitor), in naturally obese dogs. A total of 20 dogs were divided into four equal groups: one obese control (OC group), and three treated groups; DWP0.2 group, DWP0.5 group, and DWP1 group. OC group fed with food for maintenance and treated groups were fed with food for maintenance with 0.2 mg/kg DWP16001, 0.5 mg/kg DWP16001 and 1 mg/kg DWP16001, respectively. The food for maintenance was provided to dogs as 2 RER (Resting energy requirement) in kcal and DWP16001-supplemented food was administered once a day for 8 weeks.

Results
Body condition score, body weight, and fat thickness were significantly reduced (P < 0.05) in the DWP0.2 group compared with the OC group, respectively without affecting the food consumption. At the 10th week the food consumption rate was 101.35 ± 2.56, 166.59 ± 4.72, 98.47 ± 1.44 and 123.15 ± 2.45% compared with initial food consumption rate. Body fat percentage, chest and waist circumference, blood glucose, and insulin were reduced compared to OC group but not significantly different from those of the OC group during experimental period. Serum alanine aminotransferase, alkaline phosphatase, creatine phosphokinase, and creatinine were significantly reduced in DWP0.2 group on 8 weeks. Serum cholesterol and triglycerides were reduced but not significantly. No specific adverse effects were observed throughout the experiment, and hematological parameters were unchanged. The results indicate that DWP16001 was not harmful to the dogs in our study and might have anti-obesity effects in naturally obese dogs.

Conclusions
The above results and discussion suggest that DWP16001 is safe and might have anti-obesity effects in naturally obese dogs.
Fucoidan with three functions extracted from Sargassum aquifolium integrated rice-husk synthesis dual-imaging mesoporous silica nanoparticle
Authors: Lee Zui-Harng , Lee Meng-Feng , Chen Jung-Huang , Tsou Min-Hsuan , Wu Zhi-Yuan , Lee Cheng-Zhang , Huang Yu-Ya , Lin Showe-Mei , Lin Hsiu-Mei 
Published: June 2022

AbstractIn this study, we used the nanoparticle delivery system to reduce the side effect of conventional cancer treatment- radiation therapy and chemotherapy. We used rice husk silicon source mesoporous silica nanoparticle doped in Eu3+and Gd3+as the carrier in the delivery system and to enable fluorescence and MRI dual-imaging functions for follow-up therapy. In addition, we choose a popular seaweed extract—fucoidan was extracted from the same brown algae—Sargassum aquifoliumcollected from Taiwan-Pingtung-Kenting-Chuanfan Rock. In this research, we used acid hydrolysis to prepared two different molecular weight fucoidan, the small molecular fucoidan (Fus) as drug, and the molecular weight approximately 1 kDa fucoidan (Ful) as the nanoparticle gatekeeper, and as targeting molecule for overexpressed P-selectin on the surface of the metastatic tumors. The results of the cell cytotoxicity experiment showed that HCT116 cancer cells have a survival rate of approximately 58.12% when treated with 200 μg/mL fucoidan. Dual-imaging rice husk mesoporous silica nanoparticles (rMSN-EuGd) were modified with 1 kDa fucoidan (Ful) as the gatekeeper and target, and the small molecule fucoidan (Fus) was loaded into nanoparticles (Ful-Fus@rMSN-EuGd) at a concentration of 200 μg/mL. The HCT116 cancer cells had a survival rate of approximately 55.56%. The cell cytotoxicity experiment results show that Ful-Fus@rMSN-EuGd can improve the anticancer effect of fucoidan, and the nanoparticle drug delivery system using fucoidan as a drug, target, and gatekeeper was successfully synthesized.
GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients
Authors: Zeng Juanzi , Wu Heming , Liu Donghua , Li Liang , Li Jiaquan , Wang Qiuming , Ye Min , Huang Qingyan , Yu Zhikang , Zhang Jinfeng 
Published: June 2022

Abstract
Background
The link between glutathione S-transferase P1 (GSTP1) c.313A > G polymorphism and chemotherapy-related adverse events remains controversial. The goal of this study was to assess how this variant affected the toxicity of anthracycline-/paclitaxel-based chemotherapy in patients with breast cancer.

Methods
This study retrospectively investigated pharmacogenetic associations of GSTP1 c.313A > G with chemotherapy-related adverse events in 142 breast cancer patients who received anthracycline and/or paclitaxel chemotherapy.

Results
There were 61 (43.0%), 81 (57.0%), 43 (30.3%), and 99 (69.7%) patients in the T0-T2, T3-T4, N0-N1, and N2-N3 stages, respectively. There were 108 (76.1%) patients in clinical stages I–III and 34 (23.9%) patients in clinical stage IV. The numbers of patients with luminal A, luminal B, HER2 + , and triple-negative breast cancer (TNBC) were 10 (7.0%), 77 (54.2%), 33 (23.2%), and 22 (15.5%), respectively. The numbers of patients who carried GSTP1 c.313A > G A/A, A/G, and G/G genotypes were 94 (66.2%), 45 (31.7%), and 3 (2.1%), respectively. There were no statistically significant differences in the proportion of certain toxicities in patients with A/G, G/G, and A/G + G/G genotypes, except for neutropenia, in which the proportion of patients with A/G + G/G (χ2 = 6.586, P = 0.035) genotypes was significantly higher than that with the AA genotype. The logistic regression analysis indicated that GSTP1 c.313A > G mutation (A/G + G/G vs. A/A genotype) (adjusted OR 4.273, 95% CI 1.141–16.000, P = 0.031) was an independent variable associated with neutropenia.

Conclusions
The findings of this study indicate that the GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity in breast cancer patients induced by anthracycline-/paclitaxel-based chemotherapy.
Dissociation of early and late face-related processes in autism spectrum disorder and Williams syndrome
Authors: Gomez Alice , Lio Guillaume , Costa Manuela , Sirigu Angela , Demily Caroline 
Published: June 2022

Abstract
Background
Williams syndrome (WS) and Autism Spectrum Disorders (ASD) are neurodevelopmental conditions associated with atypical but opposite face-to-face interactions patterns: WS patients overly stare at others, ASD individuals escape eye contact. Whether these behaviors result from dissociable visual processes within the occipito-temporal pathways is unknown.
Using high-density electroencephalography, multivariate signal processing algorithms and a protocol designed to identify and extract evoked activities sensitive to facial cues, we investigated how WS (N = 14), ASD (N = 14) and neurotypical subjects (N = 14) decode the information content of a face stimulus.

Results
We found two neural components in neurotypical participants, both strongest when the eye region was projected onto the subject's fovea, simulating a direct eye contact situation, and weakest over more distant regions, reaching a minimum when the focused region was outside the stimulus face. The first component peaks at 170 ms, an early signal known to be implicated in low-level face features. The second is identified later, 260 ms post-stimulus onset and is implicated in decoding salient face social cues.
Remarkably, both components were found distinctly impaired and preserved in WS and ASD. In WS, we could weakly decode the 170 ms signal based on our regressor relative to facial features, probably due to their relatively poor ability to process faces’ morphology, while the late 260 ms component was highly significant. The reverse pattern was observed in ASD participants who showed neurotypical like early 170 ms evoked activity but impaired late evoked 260 ms signal.

Conclusions
Our study reveals a dissociation between WS and ASD patients and points at different neural origins for their social impairments.
Psychological and health behaviour outcomes following multi-gene panel testing for hereditary breast and ovarian cancer risk: a mini-review of the literature
Authors: Carlsson Lindsay , Thain Emily , Gillies Brittany , Metcalfe Kelly 
Published: June 2022

Abstract
Introduction
Knowledge of the genetic mechanisms driving hereditary breast and ovarian cancer (HBOC) has recently expanded due to advances in gene sequencing technologies. Genetic testing for HBOC risk now involves multi-gene panel testing, which includes well characterized high-penetrance genes (e.g. BRCA1 and BRCA2), as well as moderate- and low-penetrance genes. Certain moderate and low penetrance genes are associated with limited data to inform cancer risk estimates and clinical management recommendations, which create new sources of genetic and clinical uncertainty for patients.

Purpose
The aim of this review is to evaluate the psychological and health behaviour outcomes associated with multi-gene panel testing for HBOC risk. The search was developed in collaboration with an Information Specialist (Princess Margaret Cancer Centre) and conducted in the following databases: MEDLINE, EMBASE, EMCare, PsycINFO, Epub Ahead of Publication.

Results
Similar to the BRCA1/2 literature, individuals with a pathogenic variant (PV) reported higher levels of testing-related concerns and cancer-specific distress, as well as higher uptake of prophylactic surgery in both affected and unaffected individuals compared to those with variant of uncertain significance (VUS) or negative result. A single study demonstrated that individuals with a PV in a moderate penetrance gene reported higher rates of cancer worry, genetic testing concerns and cancer-related distress when compared to women with high penetrance PV. Analysis of cancer screening and prevention outcomes based upon gene penetrance were limited to two studies, with conflicting findings.

Conclusion
The findings in this review emphasize the need for studies examining psychological and health behavior outcomes associated with panel testing to include between group differences based upon both variant pathogenicity and gene penetrance. Future studies evaluating the impact of gene penetrance on patient-reported and clinical outcomes will require large samples to be powered for these analyses given that a limited number of tested individuals are found to have a PV.
Association of clinic setting with quality indicator performance in systemic lupus erythematosus: a cross-sectional study
Authors: Sreedharan Sidha , Li Ning , Littlejohn Geoff , Buchanan Russell , Nikpour Mandana , Morand Eric , Hoi Alberta , Golder Vera 
Published: June 2022

AbstractBackgroundHealthcare quality for systemic lupus erythematosus (SLE) is a modifiable target for improving patient outcomes. We aimed to assess the quality of care processes in different clinic settings, comparing a subspecialty lupus clinic with hospital-based and private general rheumatology clinics.MethodsPatients with SLE (n= 258) were recruited in 2016 from a subspecialty lupus clinic (n= 147), two hospital general rheumatology clinics (n= 56) and two private rheumatology clinics (n= 55). Data were collected from medical records and patient questionnaires. Quality of care was assessed using 31 validated SLE quality indicators (QI) encompassing diagnostic work-up, disease and comorbidity assessments, drug monitoring, preventative care and reproductive health. Per-QI performance was measured as a percentage of patients that met the QI relative to the number of patients eligible. Per-patient QI performance was calculated as a percentage of QIs met relative to the number of eligible QIs for each patient. Per-QI and per-patient QI performance were compared between the three clinic settings, and multiple regression performed to adjust for sociodemographic, disease and healthcare factors.ResultsPer-QI performance was generally high across all clinic settings for diagnostic work-up, comorbidity assessment, lupus nephritis, drug monitoring, prednisolone taper, osteoporosis and pregnancy care. Median [IQR] per-patient performance on eligible QIs was higher in the subspeciality lupus clinic (66.7% [57.1–74.1]) than the hospital general rheumatology (52.7% [47.5–58.1]) and private rheumatology (50.0% [42.9–60.9]) clinics (p<0.001) and the difference remained significant after multivariable adjustment. The subspecialty lupus clinic recorded higher per-QI performance for documentation of disease activity, disease damage, cardiovascular risk factor and drug toxicity assessments, pre-immunosuppression hepatitis and tuberculosis screening, new medication counselling, vaccinations, sun avoidance education and contraception counselling.ConclusionsSLE patients managed in a subspecialty lupus clinic recorded higher per-patient QI performance compared to hospital general rheumatology and private rheumatology clinics, in part related to better documentation on certain QIs.
Modelling transmission of Mycobacterium avium subspecies paratuberculosis between Irish dairy cattle herds
Authors: Biemans Floor , Tratalos Jamie , Arnoux Sandie , Ramsbottom George , More Simon J. , Ezanno Pauline 
Published: June 2022

AbstractBovine paratuberculosis is an endemic disease caused by Mycobacterium avium subspecies paratuberculosis (Map). Map is mainly transmitted between herds through movement of infected but undetected animals. Our objective was to investigate the effect of observed herd characteristics on Map spread on a national scale in Ireland. Herd characteristics included herd size, number of breeding bulls introduced, number of animals purchased and sold, and number of herds the focal herd purchases from and sells to. We used these characteristics to classify herds in accordance with their probability of becoming infected and of spreading infection to other herds. A stochastic individual-based model was used to represent herd demography and Map infection dynamics of each dairy cattle herd in Ireland. Data on herd size and composition, as well as birth, death, and culling events were used to characterize herd demography. Herds were connected with each other through observed animal trade movements. Data consisted of 13 353 herds, with 4 494 768 dairy female animals, and 72 991 breeding bulls. We showed that the probability of an infected animal being introduced into the herd increases both with an increasing number of animals that enter a herd via trade and number of herds from which animals are sourced. Herds that both buy and sell a lot of animals pose the highest infection risk to other herds and could therefore play an important role in Map spread between herds.
Degradation characteristics of biodegradable film and its effects on soil nutrients in tillage layer, growth and development of taro and yield formation
Authors: Wang An , Chang Qingtao , Chen Chunsheng , Zhong Xiaoquan , Yuan Kexiang , Yang Meihua , Wu Wei 
Published: June 2022

AbstractThis study investigated the degradation characteristics of different biodegradable film and its effects on soil nutrients in tillage layer, growth and development of taro and yield formation. Field experiment with biodegradable films, including poly-(butylene adipate-co-butylene terephthalate) PBAT, (poly-carbon dioxide) PCO2, (poly propylene carbonate) PPC, as well as common mulch film (CK1) and uncovered mulch film (CK2) were conducted on Longxiang taro in 2020 and 2021 respectively. The degradation rate of the three biodegradable films was PBAT > PPC > PCO2. Compared with CK1, the alkali-hydrolyzed N of PBAT at the growth stage and fruiting stage significantly increased in 2020 and 2021, respectively (both, P < 0.05). The average content of available P of PPC at seedling stage was higher than that in PCO2, and CK1 was significantly decreased compared with that in CK2 (all, P < 0.05). The content of soil available K and organic matter in different growth stages of taro in all film mulching treatments were decreased in comparison to CK2. Moreover, compared with CK2, PCO2 biodegradable film significantly increased plant height at seedling and growth stage, stem diameter at growth stage, and leaf area index at fruiting stage (all, P < 0.05). Similarly, the yield of mother and filial bulbs of PPC, PCO2 and PBAT were significantly higher than those of CK2 in 2020 and 2021, respectively (all, P < 0.05). However, no significant differences were found in starch, polysaccharide and protein contents among different treatments. The three biodegradable films, especially PCO2, can significantly affect soil nutrient content, promote plant growth and improve taro yield.
Effects of monthly evaluations on the rates of irrational antimicrobial prescription in the outpatient and emergency departments at Ningbo No. 6 Hospital, Ningbo, China
Authors: Yang Qiong , Yuan Fangfang , Li Li , Jin Jianfeng , He Junhong 
Published: June 2022

Abstract
Background
Antibiotic resistance is a major global public health problem. The primary cause of antibiotic resistance is inappropriate antibiotic use. In this study, we aimed to verify whether the monthly evaluation of antibiotic prescription improves clinical antibiotic use in outpatient and emergency departments.

Methods
A minimum of 25% of the prescriptions for antibacterial drugs were randomly selected at the outpatient and emergency departments to enter the monthly evaluation system from July 2016 to June 2019. We analysed the rate of irrational prescription of antibiotics, proportion of the use of antibiotics, and consistency between the evaluation and expert groups after implementing the monthly assessment to validate the role of monthly evaluations.

Results
After 3 years of monthly evaluations of antibiotic prescriptions, the utilisation rate of single antibiotics in the outpatient and emergency departments was found to increase each year. Each year, a decreasing trend was observed for the irrational use of antibiotics, whereas the proportion of antibiotics to the total drugs prescribed gradually decreased in the same period. In addition, the consistency of prescription evaluation results between the evaluation and expert groups increased continuously.

Conclusions
Monthly evaluation of antibiotic prescriptions is an effective management tool for the rational use of antibiotics in clinical practice. This practice could help reduce the combinative use of antibiotics, rate of irrational antibiotic prescription, and antibiotic use ratio, and play an important role in safe clinical drug use.
Flexural Behavior and Prediction Model of Basalt Fiber/Polypropylene Fiber-Reinforced Concrete
Authors: Fu Qiang , Zhang Zhaorui , Xu Wenrui , Zhao Xu , Zhang Lu , Wang Yan , Niu Ditao 
Published: June 2022

AbstractThe flexural behavior of basalt fiber (BF)/polypropylene fiber (PF)-reinforced concrete (BPRC) was investigated. When the content of BF and PF is 0.1%, the addition of fibers increases the compressive strength of concrete. A BF content of 0.1% has the most obvious effect on improving the compressive strength, but a hybrid fiber content of 0.2% exhibits a negative effect on the compressive strength. The addition of BF and PF can increase the flexural strength and the expansion tortuosity of the fracture cracks, thus enhancing the ductility of concrete. The hybrid fibers with content of 0.1% are most beneficial to increase the flexural strength. However, the ductility of concrete and the tortuosity of fracture crack decrease with the matrix strength, and the improvement proportion of fibers on the flexural strength also decreases. When the BF and PF are mixed, compared to the case of single fiber added, there is no significant change in the damage of BF, whereas the damage of PF is more severe. The flexural toughness index FTδ effectively characterizes the change in the flexural toughness of BPRC. The hybrid fiber contents of 0.1% and 0.2% exhibit the most significant improving effect on FT-l/600 and FT-l/150, respectively. Considering the influence of fibers on the compressive strength, flexural strength and flexural toughness of concrete, a hybrid content of 0.1% is the optimal choice of fiber content. A prediction model for flexural strength of BPRC is proposed based on the composite material theory.