bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel probiotic treatment of autism spectrum disorder associated social behavioral symptoms in two rodent models
Authors: Mintál Kitti , Tóth Attila , Hormay Edina , Kovács Anita , László Kristóf , Bufa Anita , Marosvölgyi Tamás , Kocsis Béla , Varga Adorján , Vizvári Zoltán , Cserjési Renáta , Péczely László , Ollmann Tamás , Lénárd László , Karádi Zoltán 
Published: March 2022

AbstractThe prevalence of autism spectrum disorder (ASD) has rapidly increased in the past decades, and several studies report about the escalating use of antibiotics and the consequent disruption of the gastrointestinal microbiome leading to the development of neurobehavioral symptoms resembling to those of ASD. The primary purpose of this study was to investigate whether depletion of the gastrointestinal microbiome via antibiotics treatment could induce ASD-like behavioral symptoms in adulthood. To reliably evaluate that, validated valproic acid (VPA) ASD animal model was introduced. At last, we intended to demonstrate the assessed potential benefits of a probiotic mixture (PM) developed by our research team. Male Wistar rats were used to create antibiotics treated; antibiotics and PM treated; PM treated, VPA treated; VPA and PM treated; and control groups. In all investigations we focused on social behavioral disturbances. Antibiotics-induced microbiome alterations during adulthood triggered severe deficits in social behavior similar to those observed in the VPA model. Furthermore, it is highlighted that our PM proved to attenuate both the antibiotics- and the VPA-generated antisocial behavioral symptoms. The present findings underline potential capacity of our PM to improve social behavioral alterations thus, indicate its promising therapeutic power to attenuate the social-affective disturbances of ASD.
Engineering nonlinear epileptic biomarkers using deep learning and Benford’s law
Authors: Caffarini Joseph , Gjini Klevest , Sevak Brinda , Waleffe Roger , Kalkach-Aparicio Mariel , Boly Melanie , Struck Aaron F. 
Published: March 2022

AbstractIn this study, we designed two deep neural networks to encode 16 features for early seizure detection in intracranial EEG and compared them and their frequency responses to 16 widely used engineered metrics to interpret their properties: epileptogenicity index (EI), phase locked high gamma (PLHG), time and frequency domain Cho Gaines distance (TDCG, FDCG), relative band powers, and log absolute band powers (from alpha, beta, theta, delta, low gamma, and high gamma bands). The deep learning models were pretrained for seizure identification on the time and frequency domains of 1 s, single-channel clips of 127 seizures (from 25 different subjects) using “leave-one-out” (LOO) cross validation. Each neural network extracted unique feature spaces that were interpreted using spectral power modulations before being used to train a Random Forest Classifier (RFC) for seizure identification. The Gini Importance of each feature was calculated from the pretrained RFC, enabling the most significant features (MSFs) for each task to be identified. The MSFs were extracted to train another RFC for UPenn and Mayo Clinic’s Seizure Detection Kaggle Challenge. They obtained an AUC score of 0.93, demonstrating a transferable method to identify and interpret biomarkers for seizure detection.
The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer
Authors: Haruna Miya , Ueyama Azumi , Yamamoto Yoko , Hirata Michinari , Goto Kumiko , Yoshida Hiroshi , Higuchi Naoko , Yoshida Tetsuya , Kidani Yujiro , Nakamura Yamami , Nagira Morio , Kawashima Atsunari , Iwahori Kota , Shintani Yasushi , Ohkura Naganari , Wada Hisashi 
Published: March 2022

AbstractRegulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, we investigated the features of CCR8+ Tregs in lung cancer patients. CCR8+ Tregs were highly activated and infiltration of CCR8+ Tregs in tumors was associated with poor prognosis in lung cancer patients. We also investigated their immune suppressive function, especially the influence on cytotoxic T lymphocyte cell function. The Cancer Genome Atlas analysis revealed that CD8 T cell activities were suppressed in high CCR8-expressing tumors. Additionally, depletion of CCR8+ cells enhanced CD8 T cell function in an ex vivo culture of lung tumor-infiltrating cells. Moreover, CCR8+ Tregs, but not CCR8− Tregs, induced from human PBMCs markedly suppressed CD8 T cell cytotoxicity. Finally, we demonstrated the therapeutic effect of targeting CCR8 in a murine model of lung cancer. These findings reveal the significance of CCR8+ Tregs for immunosuppression in lung cancer, especially via cytotoxic T lymphocyte cell suppression, and suggest the potential value of CCR8-targeted therapy for cancer treatment.
Ecological and societal effects of Central Asian streamflow variation over the past eight centuries
Authors: Chen Feng , Yuan Yujiang , Trouet Valerie , Büntgen Ulf , Esper Jan , Chen Fahu , Yu Shulong , Shen Miaogen , Zhang Ruibo , Shang Huaming , Chen Youping , Zhang Heli 
Published: March 2022

AbstractUnderstanding changes in water availability is critical for Central Asia; however, long streamflow reconstructions extending beyond the period of instrumental gauge measurements are largely missing. Here, we present a 785-year-long streamflow reconstruction from spruce tree rings from the Tien Shan Mountains. Although an absolute causal relationship can not be established, relatively high streamflow rates coincided roughly with the period of Mongol expansion from 1225 to 1260 CE and the rise of the Timurid Empire from 1361 to 1400 CE. Since overall wetter conditions were further found during the Zunghar Khanate period 1693–1705 CE, we argue that phases of streamflow surplus likely promoted oasis and grassland productivity, which was an important factor for the rise of inner Eurasian steppe empires. Moreover, we suggest that the streamflow variation might be critical for plague outbreaks in Central Asia, and propose several explanations for possible links with Europe’s repeated Black Death pandemics. We demonstrate that 20th-century low streamflow is unprecedented in the past eight centuries and exacerbated the Aral Sea crisis, which is one of the most staggering ecological disasters of the twentieth century.
Phonon-dressed states in an organic Mott insulator
Authors: Sono Naoki , Otaki Takashi , Kitao Takayuki , Yamakawa Takashi , Sakai Daiki , Morimoto Takeshi , Miyamoto Tatsuya , Okamoto Hiroshi 
Published: March 2022

AbstractIn an electronic system of solids excited by a femtosecond laser pulse, new quantum states called photon-dressed states are created via the coupling of original electron wavefunctions and periodic electric fields of light. The study of photon-dressed states is a central issue in nonlinear optical science, as a coherent response associated with a photon-dressed state can cause ultrafast optical-switching phenomena. In general, however, phase-sensitive dynamics of photon-dressed states are difficult to observe due to their short lifetime. Here, we show that excitation of the organic Mott insulator potassium-tetracyanoquinodimethane with a strong mid-infrared pulse induces a couple of intramolecular vibrations, which add temporally periodic potentials to the electronic system, giving rise to phonon-dressed states in the picosecond time domain. Through sub-cycle spectroscopy using a phase-stable mid-infrared pulse as an excitation and an ultrashort visible pulse as a probe, we observe optical radiation consisting of four kinds of coherent oscillations with double, sum, and differential frequencies of two intramolecular vibrations. The probe-energy dependence of each oscillation can be well interpreted with phonon-dressed states in the framework of Floquet theory. These findings open a possibility for Floquet engineering in correlated electron materials with strong charge–phonon couplings.
GaN LEDs with in situ synthesized transparent graphene heat-spreading electrodes fabricated by PECVD and penetration etching
Authors: Xiong Fangzhu , Sun Jie , Cole Matthew T. , Guo Weiling , Yan Chunli , Dong Yibo , Wang Le , Du Zaifa , Feng Shiwei , Li Xuan , Guo Tailiang , Yan Qun 
Published: March 2022

High-quality and patterned graphene is grown directly on GaN LED arrays for transparent and heat-spreading electrodes. The CVD is done at 600 °C for 2 min. Sacrificial Co acts both as GaN mesa etching mask and transfer-free graphene growth catalyst.
Preparation of in-situ ZrB2/A356 composites and high-temperature tribological studies
Authors: Li Hui , Li Chuying , Qiao Yuanpeng , Lu Shengbo , Wang Feng , Sun Caizhi , Jiao Lei , Andrii Zatulovskiy , Volodymyr Shcheretskyi 
Published: March 2022

Abstract
The ZrB2/A356 composite material was prepared by using chemical in situ reaction technology. The high-temperature friction and wear test of ZrB2/A356 aluminum matrix composites was carried out. The friction and wear test temperatures were normal temperatures, 50 °C, 100 °C, 150 °C, 200 °C, 250 °C, and 300 °C. XRD, TEM, SEM, and XPS were used to analyze the microstructure, phase and the formation of surface compounds of the composites under different wear temperatures. The results show that the composite phase is composed of ZrB2 and ɑ-Al, and there is a small amount of Al-Si eutectic phase; ZrB2 particles are small, hexagonal nearly elliptical, flocculent and well bonded to the matrix; Combined with the stress-strain curve and tensile fracture morphology analysis, the composite material is a ductile fracture, and the plasticity of the A356 alloy is higher than that of the composite material; The wear properties of composites are susceptible to temperature changes, and the wear rate is small below 200 °C. The wear mechanism is mainly oxidative wear and abrasive wear. When the temperature reaches above 250 °C, the wear rate begins to rise sharply, and a large number of plastic deformation traces and wear debris appear on the surface of the wear spot, and the surface of the wear debris adheres to the protrusions. The primary wear mechanism is adhesive wear. In the stages of oxidative wear, and abrasive wear, although the friction coefficient changes, it is stable. But in the adhesive wear stage, the friction coefficient becomes very unstable and a sharp peak appears. XPS analysis showed that the compounds formed in the wear scar were mainly Al2O3.
Effect of MOSFET dosimeters’ calibration method on calibration factors and radiation doses measured with the dosimeters in radiology
Authors: Happonen Emilia , Husso Minna , Matikka Hanna 
Published: March 2022

Abstract
MOSFET dosimeters have widely been used to measure radiation doses caused by x-rays. When using the MOSFET dosimeters, calibration factors (CFs) have a direct effect on reliability of dose measurements. The aim of this paper was to study the effect of various calibration methods on the CFs of the MOSFET dosimeters. The CFs were measured on clinical digital x-ray angiography (XA) and computed tomography (CT) devices using a calibrated CT ionization chamber and a standard polymethyl methacrylate (PMMA) phantom. The measurements were conducted by having the dosimeters (1) in air, (2) on the surface of the PMMA phantom and (3) inside the phantom. A statistically significant difference was seen between the CFs measured on the XA and CT devices. The CFs measured on the CT device were 20%–165% higher than those measured with the XA device (p < 0.001) in every calibration geometry. Furthermore, the calibration geometry had a notable effect on the CFs on CT. The CFs on the surface of the phantom were 18%–25% higher than in air (p < 0.05), and the CFs inside the phantom were 32%–39% smaller than in air (p < 0.05). These results suggest that the calibration of the MOSFET dosimeters should be conducted with the same device that is used in actual dose measurements. Also, the scattering conditions and the calibration geometry should be similar in the calibration and subsequent dose measurements.
Gated Tomographic Radionuclide Angiography Using 3D-Ring CZT StarGuide SPECT/CT Head-To-Head Comparison With a Cardiac-Dedicated CZT Camera
Authors: Carsuzaa Thibaut , Thibault Frédérique , Bailly Matthieu 
Published: March 2022

Abstract
Gated tomographic radionuclide angiography can assess and monitor left cardiac function. Dedicated cardiac CZT cameras have enabled dose reduction and quicker acquisitions. New 3D-ring CZT general purpose systems are now available. We report 50 patients who underwent a 7-minute acquisition on a cardiac-dedicated CZT camera and 9 minutes on a new 3D-ring CZT system after mean injection of 321.4 ± 55.9 MBq 99mTc-labelled human serum albumin. There was no significant difference in left ventricular volumes, and left and right ventricular ejection fractions. These preliminary results seem to validate the use of 3D-ring CZT system for LEVF and cardiac function evaluation.
Acoustic signatures in cavefish populations inhabiting different caves
Authors: Hyacinthe Carole , Attia Joël , Schutz Elisa , Casane Didier , Rétaux Sylvie 
Published: March 2022

AbstractComplex patterns of acoustic communication exist throughout the animal kingdom, including underwater. The river-dwelling and the Pachón cave-adapted morphs of the fish Astyanax mexicanus share a repertoire of sounds, but their trigger, use and meaning has changed in cavefish after their recent colonization of the subterranean environment. Here, we explored whether and how sounds produced by blind cavefishes inhabiting different Mexican caves may have evolved, too. We compared acoustic parameters of sounds produced by wild cavefish, recorded in their natural settings, in six different caves located in three mountains ranges in North-East Mexico. Multi-parametric analyses show that the six cavefish populations sampled present cave-specific acoustic signatures, as well as possible individual signatures. The variations in acoustic parameters do not seem related to fish phenotypes, phylogeography or ecological conditions. We propose that the evolution of such acoustic signatures would be neutral and occur by drift, progressively leading to the differentiation of local accents that may prevent interbreeding and thus contribute to speciation.
Organizational learning and knowledge performance at middle-cost Pakistani schools: implications for leaders
Authors: Thomas Martin , Machado Crystal 
Published: March 2022

Purpose
There is limited research in Pakistan that describes how organizational learning, which is not contingent on funding, can be used to improve the quality of education in developing countries. This study addresses this gap in the literature with a study that examines the perceptions of educators at medium-cost schools in Karachi, Pakistan.

Design/methodology/approach
As part of a larger mixed-method QUAN-qual study, this study used an instrument based on Watkins and Marsick’s Dimensions of the Learning Organization, to collect survey data from 21 head teachers/coordinators, 653 teachers at 32 urban schools. This paper presents an analysis of survey data and findings related to two research questions. This paper used exploratory factor analysis and simultaneous regression analysis to test four hypotheses.

Findings
The findings suggest that of the four levels of learning, global and school level learning predict knowledge performance at medium-cost urban schools in Karachi, Pakistan.

Practical implications
The paper includes implications for both school leaders and the education leadership faculty who prepare them to play a vital role in schools.

Originality/value
The paper adds to a limited body of literature that describes how organizational learning can be used to improve the quality of education in developing countries such as Pakistan.
The relative performance of ex‐ante and ex‐post measures to mitigate hypothetical and strategic bias in a stated preference study
Authors: Colombo Sergio , Budziński Wiktor , Czajkowski Mikołaj , Glenk Klaus 
Published: March 2022

AbstractBias related to the hypothetical setting remains controversial regarding the reliability and validity of value estimates from discrete choice experiments (DCEs). This has motivated a large body of literature to investigate approaches for mitigating hypothetical and strategic bias. Our study provides further evidence to inform this debate by testing whether a combination of ex‐ante or ex‐post mitigation strategies might be effective in reducing bias in DCEs. Specifically, we employ individual and multiple ex‐ante reminders alongside an ex‐post data treatment and analyse how their individual or joint use affects willingness to pay (WTP) estimates. The econometric analysis makes use of innovative semi‐parametric logit‐mixed logit in addition to the state‐of‐the‐art mixed logit model. The empirical case study focuses on preferences for the environmental and social impacts of organic olive production. By comparing the three experimental treatments with a control treatment, we test whether ex‐ante cheap talk, a reminder of the project's relative spatial extent, or a combination of both affect stated WTP. In addition, we use an ex‐post data treatment to correct WTP estimates. WTP estimates of treatments related to ex‐ante mitigation strategies did not differ significantly from those obtained from a control treatment with standard budget constraint reminders. However, the ex‐post approach results in a significant reduction in mean WTP estimates and is used to investigate whether the observed choice inconsistencies are due to unintentional errors or strategic behaviour. We argue that ex‐post mechanisms deserve greater attention and highlight the need to distinguish strategic behaviour from other sources of hypothetical bias.
Factors influencing parental functioning and satisfaction for veteran mothers during civilian transition
Authors: Morgan Nicole R. , Karre Jennifer K. , Aronson Keith R. , McCarthy Kimberly J. , Bleser Julia A. , Perkins Daniel F. 
Published: March 2022

AbstractObjectiveRisk and protective factors associated with parental functioning (i.e., meeting child's emotional needs) and satisfaction (i.e., closeness) were examined among post‐9/11 veteran mothers during their civilian transition.BackgroundPost–military‐separation stressors (e.g., relocation, benefit changes) can strain well‐being and familial relationships. Stress, particularly in the presence of unresolved trauma from military‐specific risks, can impinge upon parental functioning and satisfaction, negatively influencing child outcomes (e.g., social–emotional, academic, behavioral).MethodA prospective cohort was identified from all active duty service members who separated in May–September 2016. Logistic regression analyses of surveys completed by post‐9/11 veteran mothers (n = 711) assessed effects of protective (i.e., resilience) and military‐specific risk factors (i.e., deployments) on parental functioning and satisfaction. Interactions between protective factors and deployments and combat (patrols and corollaries) were explored.ResultsCoping characteristics (e.g., healthy behaviors), absence of mental health conditions, and social supports were positively associated with parental functioning and satisfaction. Household financial security was not. Mothers who had deployed reported higher parental functioning and satisfaction. Mothers experiencing combat patrols were less likely to report high parental functioning.ConclusionMalleable protective factors positively influence parenting but do not buffer against combat exposure.ImplicationsInterventions bolstering protective factors for veteran mothers can foster coping, reintegration, and positive child outcomes.
Effective learning activity to facilitate post‐graduate nursing students' utilization of nursing theories – Using the fundamentals of care framework
Authors: Jangland Eva , Gunnarsson Anna‐Karin , Hauffman Anna , Edfeldt Katarina , Nyholm Lena , Fröjd Camilla 
Published: March 2022

AbstractAimsTo explore how postgraduate nursing students used the Fundamentals of Care framework in a written assignment based on a clinical situation, and describe their learning process in using the framework.DesignA qualitative descriptive study design applying the Fundamentals of Care framework.MethodsPostgraduate nursing students' theoretical written assignments (n = 35) based on self‐experienced clinical cases were included. The data were collected in 2021 in five specialties in a postgraduate nursing programme in Sweden. The data were analysed using content analysis.ResultsApplying the framework to a self‐experienced clinical case illuminated the importance of nurse–patient relationships and clarified the meaning of person‐centred care. The students assessed the framework as easy‐to‐use bedside as a guide to providing nursing care. By using the framework, the students were aided in reasoning about the fundamental values of care such as ethics, equality in healthcare and patient rights. When students reflected on their learning process, they stated that the assignment taught them how to use the framework, as well as paving the way for finding and applying other theories of nursing.ConclusionLearning activities with an opportunity to practice analysing nursing care guided by a theory, combined with a self‐evaluating element, are conducive to deepening students' learning and improving their ability to use theories in clinical practice.ImpactThe framework illuminated the importance of the nurse–patient relationship in nursing care to the students and made them recognize and value the clinical use of theories. It is the responsibility of leaders in nurse education and healthcare to provide the next generation of specialist nurses—future nursing leaders—with regular opportunities to analyse nursing care through theories and frameworks. Nurses call for continuous learning on theories; leaders in nurse education and healthcare must meet these needs.