bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Potential Drug Therapy for Dermatofibrosarcoma Protuberans
with Bioinformatics and Deep Learning Technology
Authors: Xu Yingbin , Liu Muge , Yang Fan 
Published: August 2022

Background:
Dermatofibrosarcoma protuberans (DFSP) is a rare mesenchymal tumor that is
primarily treated with surgery. Targeted therapy is a promising approach to help reduce the high rate of
recurrence. This study aims to identify the potential target genes and explore the candidate drugs acting
on them effectively with computational methods.

Methods:
dentification of genes associated with DFSP was conducted using the text mining tool pubmed2ensembl. Further gene screening was carried out by conducting Gene Ontology (GO) and Kyoto
Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Protein-Protein Interaction
(PPI) network was constructed by using the Search Tools for the Retrieval of Interacting (STRING) database and visualized in Cytoscape. The gene candidates were identified after a literature review. Drugs
targeting these genes were selected from Pharmaprojects. The binding affinity scores of Drug-Target Interaction (DTI) were predicted by a deep learning algorithm Deep Purpose.

Results:
total of 121 genes were found to be associated with DFSP by text mining. The top 3 statistically functionally enriched pathways of GO and KEGG analysis included 36 genes, and 18 hub genes
were further screened out by constructing a PPI networking and literature retrieval. A total of 42 candidate drugs targeted at hub genes were found by Pharmaprojects under our restrictions. Finally, 10 drugs
with top affinity scores were predicted by DeepPurpose, including 3 platelet-derived growth factor receptor beta kinase (PDGFRB) inhibitors, 2 platelet-derived growth factor receptor alpha kinase (PDGFRA)
inhibitors, 2 Erb-B2 receptor tyrosine kinase 2 (ErbB-2) inhibitors, 1 tumor protein p53 (TP53) stimulant,
1 vascular endothelial growth factor receptor (VEGFR) antagonist, and 1 prostaglandin-endoperoxide
synthase 2 (PTGS2) inhibitor.

Conclusion:
Text mining and bioinformatics are useful methods for gene identification in drug discovery.
DeepPurpose
Acute Myocardial Infarction in Young Patients and its Correlation with Obesity Status at Pre-adolescent Stage: A Narrative Review
Authors: Chrissini Maria K. , Panagiotakos Demosthenes B. 
Published: August 2022

Background:
Cardiovascular diseases (CVD), especially acute myocardial infarction (AMI), remain a worldwide major cause of premature morbidity and mortality, with considerable health care costs. Metabolic, behavioural, environmental, and social risk factors are significant drivers of AMI, with obesity being a key determinant among them. Childhood obesity constitutes a major health threat that is considered a global epidemic of the 21st century.

Objective:
To assess whether excess weight from the first years of life acts as a predisposing factor in increasing the risk of AMI in young adults.

Methods:
This is a narrative review of the evidence concerning the epidemiology of early AMI and obesity, using PubMed and Google Scholar.

Results:
There is substantial evidence showing that excess weight during childhood multiplies the risk of AMI at an early age.

Conclusion:
Premature AMI seems to have significant drivers related to lifestyle factors, such as childhood obesity. In the era of a childhood obesity epidemic, the aforementioned relationship underlines the need for early prevention and management.
Status of Childhood Eye Care Services in the Kingdom of Saudi Arabia: Eye Care Professionals’ Perspectives
Authors: Moafa Majid A. , Alrasheed Saif H. 
Published: August 2022

Background:
The World Health Organization (WHO) reported that there are approximately 19 million visually impaired children worldwide, and most of the conditions are treatable by early intervention at the primary, secondary, and tertiary levels.

Objective:
To assess the status of paediatric eye care services in the Kingdom of Saudi Arabia

Methods:
A cross-sectional study was conducted among eye care professionals (optometrists and ophthalmologists) in public sector hospitals in various regions of Saudi Arabia. Data were collected through an online self-administered paediatric eye care service questionnaire based on a validated questionnaire.

Results:
A total of 137 completed questionnaires were obtained, with a response rate of 83%. The highest percentage of trained paediatric teams at hospitals was recorded at 95% in the eastern region (p= 0.024), while the lowest percentage was 44% in the southern region. Trained paediatric nurses were available in 88% of the eastern region hospitals, followed by 56% of the central region hospitals (p= 0.001). Services such as separate paediatric optometry clinics, dedicated ophthalmology outpatient clinics, and advanced diagnostic equipment were significantly higher in number in the eastern region than in the other regions (p˂0.001). The general status of human resources of eye professionals reveals that 73% of the facilities had both trained optometrists and ophthalmologists, approximately 70.8% had anaesthesiologists available, and almost 73.7% had easy access to available paediatricians.

Conclusion:
The overall quality of paediatric eye-related health care is satisfactory in most Saudi regions. However, there are some discrepancies among the regions in paediatric eye care services and facility types, which may need to be addressed by decision-makers in the Ministry of Health.
Validated Reverse Phase-High-Performance Liquid Chromatography
Method for Simultaneous Determination of Vanillic acid and Glyburide in
Amphiphilic Polymeric Micelles
Authors: Singh Sachin Kumar , Kaur Jaskiran , Gulati Monica , Pandey Narendra Kumar , Kumar Bimlesh , Singh Saurabh 
Published: August 2022

Background:
A new sensitive and rapid reverse phase HPLC method was developed for the
simultaneous determination of vanillic acid (VA) and glyburide in the formulation and validated according
to (ICH) Q2 (R1) guidelines.

Methods:
The HPLC analysis was performed using the C-18 reverse phase column and a mobile phase
consisting of acetonitrile and orthophosphoric acid (0.1% v/v) of ratio 70:30 v/v at 1 mL/min of flow rate.
The detection was performed at the wavelength (λ) of 234 nm (isosbestic point), and the retention time of
VA and glyburide was found around 2.6 and 5.4 min. The calibration plot gave a linear relationship over
the concentration range of 2–10 μg/mL with a regression coefficient of 0.999. The LOD and LOQ for VA
were 0.34 and 1.04 μg/mL, while for glyburide it was 0.38 μg/mL and 1.17 μg/mL respectively. The accuracy
of the proposed method was determined by recovery studies and was in the range of 95% to 105%.
The RSD% of the determination of precision was <2%.

Results:
The results of the robustness study were within the acceptable limits in response to changes in
flow rate, ratio of mobile phase, and pH. The method was successfully applied for the determination of
EE% and drug release from amphiphilic polymeric micelles.

Conclusion:
The EE% of both the drugs prepared in a liquid formulation of amphiphilic polymeric micelles
was found to be greater than 90%. The results of drug release studies indicated almost 100% VA
and 85.3% glyburide release using pH-gradient method within 4 and 48 h respectively.
Selection of Suitable Dielectric Substrate for Miniaturization of Microstrip
Patch Antenna Using DGS Fractals
Authors: Mohanty Saumendra Kumar , Dash Shibanee 
Published: August 2022

Background:
Antennas size reduction with good performance characteristics is an essential part of designing a microstrip patch antenna (MPA) to select a suitable dielectric substrate.

Methods:
A conventional MPA is designed at 10GHz frequency, and later Minkowski fractal (1st
iteration) defected ground structure (DGS) technique is applied for size reduction. The design is
made to keep the radiation and reflection characteristics in contention.

Results:
A miniaturized MPA with 11% size reduction has been simulated using HFSS. The simulation results show the realization and selection of the substrate materials in the design process. Here,
five different substrates are judiciously implemented and later compared. The comparison is made
based on return loss, bandwidth, impedance, gain and efficiency

Conclusion:
We found a miniaturized MPA using the proposed first iteration of Minkowski fractal
DGS. This MPA is suitable for X-band satellite communication and may be applied in government
institutions, civil, military, monitoring weather, air traffic, defence tracking, maritime vessel traffic,
etc., due to conformal and planar shape with reduced electrical length at 10GHz operating frequency
Controlled impacts for structure formation and properties of cement concretes
Authors: Ivaschenko Yu. G. , Mameshov R. T. 
Published: August 2022

Objective. The paper considers controlled effects on changes in the properties of components and the control effect of technological methods and techniques for obtaining composite building materials with a set of specified properties.Method. Methods of mechano-physical, physicochemical, nanotechnological influence were applied.Result. The system-structural approaches are systematized and generalized by control actions at the stage of structure formation, technological stages, formation of the optimal structure and properties of cement concrete. The physicochemical principles and mechanisms of structure formation are given, based on establishing the role of controlling the mechano-physical, physico-chemical, nanotechnological methods of influencing the cement-water system. The possibility of controlling structural transformations in binder systems, including through the use of technological influences, has been revealed.Conclusion. The implementation of the impacts on the components of cement concretes will ensure the targeted design of the structures of modern building materials.
Investigation of various types of biological corrosion of concrete
Authors: Loginova S. A. , Petrenko A. A. 
Published: August 2022

Objective. Determination of the degree of development of various types of microorganisms and their effect on the physical and mechanical properties of concrete.Method. Assessment of the possibility of concrete to serve as a substrate for various types of biodestructors was carried out using the determination of moisture absorption and pH of water drawing of concrete samples.Result. Experimental mechanism of action of various microorganisms on concrete is established. Taxonomic composition of microorganisms most aggressive to concrete is determined. The impact of biofouling on the physical and mechanical properties of concrete was assessed.Conclusion. The results of the investigation serve as the basis for competent selection of the most effective methods of corrosion protection of concrete structures operating in biologically aggressive environments.
Information security of business networks
Authors: Losev A. S. 
Published: August 2022

Objectives. The aim of the work is to improve the information security of businesstype networks, as the most susceptible to external threats for the purpose of commercial espionage.Method. The study is based on the use of an original mathematical algorithm that allows clustering networks of arbitrary topology and constructing a partial order matrix. On the one hand, clustering allows you to identify network agents that have the same information access to the network, on the other hand, partial order reflects the position of a single cluster in the hierarchical structure of the entire network.Result. This approach allows assessing the potential threat to the network depending on the position of the agent in the network that has been attacked. On its basis, a methodology has been developed to determine the degree of openness of an entrepreneurial network to the influence of external factors for each agent of the network. It allows you to identify network agents that require increased security in relation to external influences, since a potential attack on them has the most negative consequences for the entire connection, which emphasizes the practical significance of the result.Conclusion. The developed technique is practically significant and can be used to assess the information security or integrity of a network of any nature, represented as a directed graph.
Invariants in problems of pattern recognition and control of states of complex objects
Authors: Melekhin V. B. , Khachumov V. M. , Khachumov M. V. 
Published: August 2022

Objective. The aim of the study is to build emulators of the main sensors of a small spacecraft (SC).Method. The quality of recovery is determined by the standard deviation (RMS) of the data from the standards. The study is based on the application of the dynamic programming method.Result. A review of works in the field of application of stable characteristics - invariants, in the applied areas of pattern recognition and state control of complex technical systems is carried out. A method aimed at identifying failures and building small spacecraft sensor emulators based on the analysis of stable indicators: correlation and covariance coefficients is proposed and tested. The proposed approach makes it possible to increase the overall reliability of the information-measuring system of a small spacecraft (SC). In the future, to emulate a failed sensor, it is planned to use multiple correlation of time sequences.Conclusion. In the general case, recognition is reduced to comparing the graph structures of objects to the correct matching of hierarchical image models based on various invariants. Control of the states of complex systems is based on the use of stable characteristics that act as invariant or subinvariant descriptors. Invariants in various applications help to recognize the current situation with a sufficient degree of accuracy, usually reducing the dimension of the problem.
Patients’ and Health Care Providers’ Perceptions on mHealth Use After High-Altitude Climate Therapy for Severe Asthma: Mixed Methods Study
Authors: Khusial Rishi , van Koppen Sophia , Honkoop Persijn , Rijssenbeek-Nouwens Lucia , Fieten Karin Berthine , Keij Sascha , Drijver-Messelink Marieke , Sont Jacob 
Published: August 2022

Background
Asthma is a common chronic disease with various clinical presentations. Although most patients are able to reach good asthma control, some patients are not able to reach sufficient asthma control following the regular treatment guidelines and could be referred to high-altitude climate therapy (HACT). HACT includes environmental trigger avoidance in the alpine climate with multidisciplinary clinical treatment. Patients with severe and difficult-to-control asthma, who are unable to reach asthma control at sea level, can follow a 12-week lung rehabilitation program at 1600 m above sea level. Mobile health (mHealth) tools can be used to enhance self-management in these patients when they return home. For an mHealth system to be effective, it must meet the expectations of the end users.

Objective
In this Davos@home study, we explored the attitudes toward mHealth aimed at supporting the self-management of patients with severe, difficult-to-control asthma who underwent HACT and asthma health care providers.

Methods
In the first stage, interviews with referrers to HACT and focus groups with patients with asthma who participated in or completed HACT were conducted. The data were then analyzed thematically. On the basis of these results, a questionnaire was developed. In the second stage of the study, this questionnaire, combined with the Asthma Control Questionnaire and the Individual Innovativeness Questionnaire, was provided to patients who completed HACT.

Results
In total, 11 interviews and 3 focus groups (n=18, age 47.6, SD 12.1 years, Asthma Control Questionnaire score 2.6, SD 1.0) were conducted. A total of 3 themes were identified: potential goals, useful measurements, and perceived barriers and facilitators. The questionnaire developed in stage 2 included items based on these results. The most agreed-upon goal among the 52 patients who completed the questionnaire was to increase their asthma control (45/52, 86% of the patients).

Conclusions
Different patients reported that they would benefit the most from different functionalities. Therefore, it is important to tailor functionalities to individual (treatment) goals. When developing an mHealth intervention, it is important to allow personalization to avoid overwhelming the users.
Digital Health Care Industry Ecosystem: Network Analysis
Authors: Park Yoonseo , Park Sewon , Lee Munjae 
Published: August 2022

Background
As the need for digital health care based on mobile devices is increasing, with the rapid development of digital technologies, especially in the face of the COVID-19 pandemic, gaining a better understanding of the industrial structure is needed to activate the use of digital health care.

Objective
The aim of this study was to suggest measures to revitalize the digital health care industry by deriving the stakeholders and major issues with respect to the ecosystem of the industry.

Methods
A total of 1822 newspaper articles were collected using Big Kings, a big data system for news, for a limited period from 2016 to August 2021, when the mobile health care project was promoted in Korea centered on public health centers. The R and NetMiner programs were used for network analysis.

Results
The Korean government and the Ministry of Health and Welfare showed the highest centrality and appeared as major stakeholders, and their common major issues were “reviewing the introduction of telemedicine,” “concerns about bankruptcy of local clinics,” and “building an integrated platform for precision medicine.” In addition, the major stakeholders of medical institutions and companies were Seoul National University Hospital, Kangbuk Samsung Hospital, Ajou University Hospital, Samsung, and Vuno Inc.

Conclusions
This analysis confirmed that the issues related to digital health care are largely composed of telemedicine, data, and health care business. For digital health care to develop as a national innovative growth engine and to be institutionalized, the development of a digital health care fee model that can improve the regulatory system and the cost-effectiveness of patient care, centering on the Ministry of Health and Welfare as a key stakeholder, is essential.
Ranolazine Versus Allopurinol for Eligible Symptomatic Patients With a History of Angioplasty: Comparative Efficacy Study
Authors: Rahmani Reza , Moradi Farsani Ehsan , Bahrami Sima 
Published: August 2022

Background
Recurrent angina, which is defined as a return of chest pain or chest discomfort, occurs in many patients undergoing coronary interventions.

Objective
This study aims to compare the antianginal efficacy of ranolazine versus allopurinol for eligible symptomatic patients with a history of angioplasty.

Methods
A total of 62 eligible symptomatic patients with a history of angioplasty were randomly allocated into two groups. For group A, 300 mg of allopurinol was administered twice daily, while for group B, 1000 mg of ranolazine daily was prescribed for a duration of 4 weeks. An initial screening visit was done for all participants where patients’ medical history was recorded and a physical examination was given; electrocardiography, blood pressure, and heart rate measurements were done as well. The patients were also given a blood and exercise test. At the end of the medication period, participants were revisited, and the tests were done again. All the required data were collected via a researcher-made form, and data analysis was conducted using SPSS. The study was approved by a formal ethics committee.

Results
The mean age of participants in the two groups (A and B) was 57.36 (SD 8.36) and 60.27 (SD 9.17) years, respectively. Among the 62 patients, 34 (59%) were men, while 28 (41%) were women. Creatinine, fasting blood sugar, C-reactive protein, N-terminal prohormone of brain natriuretic protein, uric acid, white blood cell, and hemoglobin levels of participants were not significantly different between groups (P>.05). Both allopurinol and ranolazine increased the total exercise time and decreased the ST depression of the patients. Additionally, they both improved the chest pain severity and Duke Treadmill Score of patients. At the same time, ranolazine had a statistically greater effect on ST depression reduction (mean 2.64, SD 0.74 vs mean 1.57, SD 0.49), while allopurinol showed better efficacy in reducing chest pain severity (mean 1.86, SD 0.37 vs mean 0.59, SD 0.21) and the Duke Treadmill Score (mean –14.77, SD 3.65 vs mean –6.88, SD 1.93).

Conclusions
Based on the results, the antianginal efficacy of allopurinol and ranolazine was approved but with different effects on ST depression, chest pain severity, and the Duke Treadmill Score. Therefore, the precise differences in their effects need to be explored further.
The Effects of Virtual Reality Tele-exergaming on Cardiometabolic Indicators of Health Among Youth With Cerebral Palsy: Protocol for a Pilot Randomized Controlled Trial
Authors: Lai Byron , Davis Drew , Young Raven , Kimani-Swanson Erin , Wozow Cynthia , Wen Huacong , Kim Yumi , Wilroy Jereme , Rimmer James 
Published: August 2022

BackgroundYouth with cerebral palsy do not have enjoyable, accessible, and scalable exercise options that can empower them to independently maintain their cardiometabolic health.ObjectiveThe primary aim is to examine the preliminary efficacy of a 12-week home-based virtual reality tele-exergaming intervention on several indicators of cardiometabolic health in youth with cerebral palsy compared to the wait list control. A secondary aim is to describe feasibility metrics, namely, recruitment, retention, and adherence rates; perceived enjoyment; intervention safety; and management issues. The tertiary aim is to generate a theory that reveals critical behavioral mechanisms of adherence to tele-exergaming.MethodsIn this parallel group design randomized controlled trial, 34 inactive youths with cerebral palsy are randomly allocated to one of two groups: a group that immediately receives 12 weeks of virtual reality exergaming with tele–physical education or a wait list control group that undergoes their habitual activity for 12 weeks. Participants are recruited from a Children’s Hospital and community network. At baseline (week 0), week 6, and week 12, high sensitivity C-reactive protein and blood insulin, hemoglobin A1c, triglycerides, cholesterol, and pressure are measured by the youth and a caregiver at home using a blood spot test kit and blood pressure cuff. They will also self-measure their lung function and body weight using a peak flow meter and bathroom scale, respectively. Collections are supervised by research staff via videoconference. Changes in outcomes are compared between and within groups using exploratory statistical analyses and descriptive statistics. At postintervention or dropout, participants will undergo semistructured interviews to identify behavioral mechanisms that underly participation.ResultsRecruitment procedures started in June 2022. All data are expected to be collected by October 2023. Full trial results are expected to be published by February 2024. Secondary analyses of data will be subsequently published.ConclusionsThis trial tests an innovative serious exergaming virtual reality program that includes a completely remote enrollment, assessment, and intervention tele-protocol. The knowledge obtained will inform the development of a larger effectiveness trial for improving the health and well-being of youth with cerebral palsy.Trial RegistrationClinicalTrials.gov NCT05336227; https://clinicaltrials.gov/ct2/show/NCT05336227International Registered Report Identifier (IRRID)PRR1-10.2196/40708