bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enzyme-treated chicory for cosmetics: application assessment and techno-economic analysis
Authors: Häkkinen Suvi Tuulikki , Cankar Katarina , Nohynek Liisa , Suomalainen Marjut , van Arkel Jeroen , Siika-Aho Matti , Twarogowska Anna , Van Droogenbroeck Bart , Oksman-Caldentey Kirsi-Marja 
Published: December 2022

AbstractChicory (Cichorium intybus L.) is an important industrial crop that produces large quantities of the dietary fiber inulin in its roots. Following inulin extraction, the bagasse is typically used as animal feed, but it contains numerous bioactive secondary metabolites with potential applications in healthcare and cosmetic products. Here we assessed the antimicrobial properties of chicory biomass pre-treated with various enzymes alone and in combination to release the bioactive compounds and increase their bioavailability. We found that pre-treatment significantly increased the antimicrobial activity of this industrial by-product, yielding an extract that inhibited typical skin pathogens in a cosmetic formula challenge test. We also evaluated the valorization of chicory biomass as a bioactive cosmetic ingredient. Economic feasibility was estimated by combining our experimental results with a conceptual techno-economic analysis. Our results suggest that chicory biomass can be utilized for the sustainable production of efficacious cosmetic ingredients.
The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study
Authors: Pan Guo-Qiang , Yang Chun-Cheng , Shang Xiao-ling , Dong Zhao-Ru , Li Tao 
Published: December 2022

Abstract
Background
Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response to treatment. The influence of white blood cell (WBC) subtype counts on HCC progression remains unclear.

Methods
In this study, we performed a Mendelian randomization (MR) study with the validation of two datasets. The summary data for WBC counts were extracted from a recent large GWAS of individuals of European ancestry. The GWAS data related to HCC were obtained from the UK Biobank (UKB). Univariable and multivariable MR analyses were used to identify risk factors genetically associated with HCC risks.

Results
In the discovery dataset, multivariable MR analysis revealed that sum basophil neutrophil counts had an independent causal effect on the occurrence of HCC, with the sum basophil neutrophil counts as follows: (OR = 0.437, P = 0.003, CI 0.252–0.757). Similarly, in the validation dataset, total basophil neutrophil counts were also been identified as an independent risk factor for HCC. The sum basophil neutrophil counts were as follows: (OR = 0.574, P = 0.021, CI 0.358–0.920).

Conclusion
In the European population, genetically predicted lower total basophil neutrophil counts might be an independent risk factor for HCC.
Building capacity in quantitative research and data storytelling to enhance knowledge translation: a training curriculum for peer researchers
Authors: Lo Hog Tian Jason M. , Watson James R. , Deyman Megan , Tran Billy , Kerber Paul , Nanami Kajiko , Norris Deborah , Samson Kim , Cioppa Lynne , Murphy Michael , Mcgee A. , Ajiboye Monisola , Chambers Lori A. , Worthington Catherine , Rourke Sean B. 
Published: December 2022

Abstract
Background
Many community-based HIV research studies incorporate principles of greater involvement and meaningful engagement of people living with HIV (GIPA/MEPA) by training people with HIV as peer researchers. Unfortunately, there are still some aspects of research (e.g., quantitative data analysis and interpretation) where many projects fall short in realizing GIPA/MEPA principles. To address these gaps, we developed an eight-week training course that aimed to build the capacity of peer researchers around the understanding and interpretation of quantitative data and incorporating lived experience to increase the impact of the knowledge transfer and exchange phase of a study.

Methods
Peer researchers (n = 8) participated from British Columbia, Alberta, and Ontario and lessons learned from the training were implemented throughout the dissemination of research findings from the People Living with HIV Stigma Index study. This paper presents the curriculum and main training components, course evaluation results, and challenges and lessons learned. The manuscript was created in collaboration with and includes the perspectives of both the peer researchers involved in the training, as well the course facilitators.

Results
Throughout the course, peer researchers’ self-assessed knowledge and understanding of quantitative research and data storytelling improved and, through interactive activities and practice, they gained the confidence to deliver a full research presentation. This improved their understanding of research findings, which was beneficial for discussing results with community partners and study participants. The peer researchers also agreed that learning about integrating lived experience with quantitative data has helped them to make research findings more relatable and convey key messages in a more meaningful way.

Conclusions
Our training curriculum provides a template for research teams to build capacity in areas of research where peer researchers and community members are less often engaged. In doing so, we continue to uphold the principles of GIPA/MEPA and enhance the translation of research knowledge in communities most greatly affected.
Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls
Authors: Saremi Leila , Shafizadeh Marziyeh , Ghaffari Mohammad Ebrahim , Aliniagerdroudbari Ehsan , Amid Reza , Kadkhodazadeh Mahdi 
Published: December 2022

Abstract
Background
Chronic periodontitis (CP) is a prevalent infectious disease caused by an interplay between pathogens and immune responses. Gene polymorphisms are among the factors that affect susceptibility to CP. This study aimed to assess the association between CP and single nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10), interleukin 1ß (IL-1ß), and tumor necrosis factor-α (TNF-α) genes.

Methods
A total of 87 patients with CP and 89 healthy controls were included in this study. Venous blood samples were obtained, and DNA was extracted and purified. Segments containing the relevant genes were amplified by polymerase chain reaction (PCR). Electrophoresis was performed after restriction fragment length polymorphism (RFLP) to determine genotype and allele frequencies.

Results
The CP group showed significantly different allele and genotype frequencies for three out of five SNPs: IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, and IL-1ß + 3954 C/T (p < 0.05). Additionally, the frequency of the TNF-α ─ 857 AA genotype was significantly lower in patients compared with controls (p = 0.034); however, no significant differences were found in allele frequencies (p > 0.05). Logistic regression analysis revealed that carriers of IL-10 ─ 592 A allele and IL-1ß + 3954 T allele are at higher risk of CP (p < 0.001). Allele and genotype frequencies for TNF-α ─ 308 G/A did not differ significantly between patients and controls (p > 0.05).

Conclusions
This study showed specific genotypes of IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, IL-1ß + 3954 C/T, and TNF-α ─ 857 G/A SNPs may be associated with an increased risk of CP development.
Cardiac imaging findings in anomalous origin of the coronary arteries from the pulmonary artery; narrative review of the literature
Authors: Ajam Ali , Rahnamoun Zahra , Sahebjam Mohammad , Sattartabar Babak , Razminia Yasaman , Ahmadi Tafti Seyed Hossein , Hosseini Kaveh 
Published: December 2022

Abstract
Introduction
Anomalous origin of the right coronary artery from the pulmonary artery (ARCAPA) is a rare coronary artery malformation with an incidence of 0.002% in patients undergoing coronary angiography. It can lead to an increased risk of myocardial infarction (MI) and sudden cardiac death, even in asymptomatic patients.

Methods
We conducted a review of published cases of ARCAPA using PubMed and Scopus databases and included patients over 18 years old with adequate echocardiographic data.

Results
We evaluated 28 patients with ARCAPA with a mean age of 42.8 from 1979 to 2021. Patients were diagnosed mostly by angiography and echocardiography, the most performed treatment was reimplantation (15, 53.6%) and the main echocardiographic findings were dilated coronary arteries (9, 32.1%), coronary collaterals (8, 28.6%), and retrograde flow from right coronary arteries to main pulmonary trunk (7, 25%).

Conclusion
Although ARCAPA is rare and not as deadly as the anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) still there is a chance of serious outcomes, therefore surgical treatment should be performed upon diagnosis. Angiography is the gold standard for diagnosis, but echocardiography can be a convenient, non-invasive, and most reliable method as the primary step whenever ARCAPA is suspected.
Understanding the Impact of Medicaid-Serving Primary Care Team Functioning and Clinical Context on Cancer Care Treatment Quality: Implications for Addressing Structural Inequities
Authors: O'Malley Denalee M. , Doose Michelle , Howard Jenna , Cantor Joel C. , Crabtree Benjamin F. , Tsui Jennifer 
Published: December 2022

PURPOSE: Primary care factors related to Medicaid enrollees' receipt of guideline concordant cancer treatment is understudied; however, team structure and processes likely affect care disparities. We explore Medicaid-serving primary care teams functioning within multiteam systems to understand performance variations in quality of breast and colorectal cancer care. METHODS: We conducted a comparative case study, using critical case sampling of primary care clinics in New Jersey, to provide maximum variation on clinic-level care performance rates (Medicaid enrollees' receipt of guideline-concordant treatment). Site evaluations, conducted from 2019 to 2020, included observation (2-3 days) and interviews. Using a multistep analytic process, we explored contextual factors within primary care that may contribute to cancer care performance variations. RESULTS: We identified performance variations stemming from adaptations of multiteam system inputs and processes on the basis of contextual factors (ie, business model, clinic culture). Team 1 (average performer), part of a multisite safety-net clinic system, mainly teamed outside their organization, relying on designated roles, protocol-based care, and quality improvement informed by within-team metrics. Team 2 (high performer), part of a for-profit health system, remained mission-driven to improve urban health, teamed exclusively with internal teams through electronically enabled information exchange and health system–wide quality improvement efforts. Team 3 (low performer), a physician-owned private practice with minimal teaming, accepted Medicaid enrollees to diversify their payer mix and relied on referral-based care with limited consideration of social barriers. CONCLUSION: Primary care team structures and processes variations may (in part) explain performance variations. Future research aiming to improve care quality for Medicaid populations should consider primary care teams' capacity and context in relation to composite teams to support care quality improvements in subsequent prospective trials.
The genome sequence of the setaceous Hebrew character, Xestia c-nigrum, (Linnaeus, 1758)
Authors: Broad Gavin R. , Boyes Douglas ,   Natural History Museum Genome Acquisition Lab,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: December 2022

We present a genome assembly from an individual male Xestia c-nigrum (the setaceous Hebrew character; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 760 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the assembled Z sex chromosome. The mitochondrial genome has also been assembled and is 15.3 kilobases in length.
Hair loss following COVID-19 infection - the state of current knowledge and treatment approaches.
Authors: Rudziński Gracjan , Kusak Natalia , Brzuszkiewicz Kinga , Łozowski Borys , Grunwald Arkadiusz , Dalmata Weronika 
Published: December 2022

Introduction: Telogen effluvium is a non-scarring hair loss that can occur after COVID-19 infection. It usually occurs after about 3 months, causes diffused hair loss and lasts up to 6 months. The purpose of this narrative review is to collect and summarize the effects of potential methods to promote hair regrowth in patients after COVID-19 infection.
Material and method: The article reviews available in PubMed and ResearchGate databases, studies on telogen effluvium and SARS-CoV-2. Due to the limited literature, articles on telogenetic hair loss progressing independently of COVID-19 were also included in the review.
Results: Hair loss after COVID-19 infection occurs in almost 30% of patients. This is likely related to pro-inflammatory cytokines released during infection and the pro-thrombotic effect of the virus. Telogen effluvium is the most common type of alopecia occurring after COIVD-19 infection - about 86% of all cases. It affects women more often than men. It seems that its severity may correlate with the severity of the infection. Other than female gender and a history of chronic disease, it is unlikely to find any other contributing factors. Effective treatments seem to include the use of oral supplements such as vitamin D, polyunsaturated fatty acids and zinc. In addition, topical application of minoxidil and high-platelet plasma treatments have shown good outcomes.
Conclusions: Given the fairly common occurrence of hair loss after COVID-19 infection, it seems reasonable to seek the most effective strategies for its treatment. At present, it appears that the best results are obtained by combining different treatment approaches.
High-bandwidth image-based predictive laser stabilization via optimized Fourier filters
Authors: Natal Joseph , Barber Samuel , Isono Fumika , Berger Curtis , Gonsalves Anthony J. , Fuchs Matthias , van Tilborg Jeroen 
Published: December 2022

Controlling the delivery of kHz-class pulsed lasers is of interest in a
variety of industrial and scientific applications, from
next-generation laser-plasma acceleration to laser-based x-ray
emission and high-precision manufacturing. The transverse position of
the laser pulse train on the application target is often subject to
fluctuations by external drivers (e.g., room cooling and
heating systems, motorized optics stages and mounts, vacuum systems,
chillers, and/or ground vibrations). For typical situations where the
disturbance spectrum exhibits discrete peaks on top of a
broad-bandwidth lower-frequency background, traditional PID
(proportional-integral-derivative) controllers may struggle, since as
a general rule PID controllers can be used to suppress vibrations up
to only about 5%–10% of the sampling frequency. Here, a predictive
feed-forward algorithm is presented that significantly enhances the
stabilization bandwidth in such laser systems (up to the Nyquist limit
at half the sampling frequency) by online identification and filtering
of one or a few discrete frequencies using optimized Fourier filters.
Furthermore, the system architecture demonstrated here uses
off-the-shelf CMOS cameras and piezo-electric actuated mirrors
connected to a standard PC to process the alignment images and
implement the algorithm. To avoid high-end, high-cost components, a
machine-learning-based model of the piezo mirror’s dynamics was
integrated into the system, which enables high-precision positioning
by compensating for hysteresis and other hardware-induced effects. A
successful demonstration of the method was performed on a 1 kHz laser
pulse train, where externally-induced vibrations of up to 400 Hz were
attenuated by a factor of five, far exceeding what could be done with
a standard PID scheme.
Fabrication of biconvex spherical and aspherical lenses using 3D printing
Authors: Aguirre-Aguirre Daniel , Gonzalez-Utrera Dulce , Villalobos-Mendoza Brenda , Díaz-Uribe Rufino 
Published: December 2022

In this work, we present the methods of fabrication and characterization of biconvex spherical and aspherical lenses with 25 and 50 mm diameters that have been created via additive technology using a Formlabs Form 3 stereolithography 3D printer. After the prototypes are postprocessed, fabrication errors

≤

2.47

%

for the radius of curvature, the optical power, and the focal length are obtained. We show eye fundus images captured with an indirect ophthalmoscope using the printed biconvex aspherical prototypes, proving the functionality of both the fabricated lenses and the proposed method, which is fast and low-cost.
Full-field x-ray fluorescence imaging using a Fresnel zone plate coded aperture
Authors: Soltau Jakob , Meyer Paul , Hartmann Robert , Strüder Lothar , Soltau Heike , Salditt Tim 
Published: December 2022

We present an approach to full-field x-ray fluorescence imaging that uses a Fresnel zone plate as a coded aperture positioned between the object and detector. For this particular coded aperture, the incoherent image formation is identical to the coherent propagation image (inline hologram) of an equivalent absorption object. In the first experiment, we show that prior knowledge of the coded aperture structure and position is no longer required. Fast and robust reconstruction algorithms well known from coherent imaging can be applied. We demonstrate the approach using x-ray fluorescence excited by a collimated Cu-

K
α

beam at an ordinary laboratory x-ray source. Images are recorded with a field of view of

1

m
m

2

and resolution of 35 µm. The simple and efficient imaging scheme is well suited for further dissemination of x-ray fluorescence imaging and translation to a broader user community, which could take advantage of full-field imaging with chemical contrast. More generally, the scheme also enables full-field imaging of other incoherent radiation processes for which lenses are either not available at all or not with sufficient numerical apertures. Examples include Compton imaging, imaging of inelastic neutron scattering, or

γ

-ray imaging in nuclear medicine.
Comparison of neural mobilization and conservative treatment on pain, range of motion, and disability in cervical radiculopathy: A randomized controlled trial
Authors: Rafiq Shazia , Zafar Hamayun , Gillani Syed Amir , Waqas Muhammad Sharif , Zia Amna , Liaqat Sidrah , Rafiq Yasir 
Published: December 2022

Objective
The objective of the study was to compare the effectiveness of neural mobilization technique with conservative treatment on pain intensity, cervical range of motion, and disability.

Methods
It was a randomized clinical trial; data was collected from Mayo Hospital, Lahore. Eighty-eight patients fulfilling the sample selection criteria were randomly assigned into group 1 (neural mobilization) and group 2 (conventional treatment). Pain intensity was measured on a numeric pain rating scale, range of motion with an inclinometer, and functional status with neck disability index (NDI). Data were analyzed using SPSS, repeated measure ANOVA for cervical ranges and the Friedman test for NPRS and NDI were used for within-group analysis. Independent samples t-test for cervical ranges and Mann-Whitney U test for NPRS and NDI were used for between-group comparisons.

Results
There was a significant improvement in pain, disability, and cervical range of motion after the treatment in both groups compared to the pre-treatment status (p < 0.001), and when both groups were compared neural mobilization was more effective than conventional treatment in reducing pain and neck disability (p < 0.001), but there was no significant difference present in the mean score of cervical range of motion between both groups. (p>0.05).

Conclusions
The present study concluded that both neural mobilization and conservative treatment were effective as an exercise program for patients with cervical radiculopathy, however, neural mobilization was more effective in reducing pain and neck disability in cervical radiculopathy.

Trial registration
RCT20190325043109N1.
The Modern Short Story and Magazine Culture, 1880-1950, Elke D’hoker and Chris Mourant (eds) (2021)
Authors: Tura Vecino Aleix 
Published: December 2022

Review of: The Modern Short Story and Magazine Culture, 1880-1950, Elke D’hoker and Chris Mourant (eds) (2021)
Edinburgh: Edinburgh University Press, 336 pp.,
ISBN 978-1-47446-108-5, h/bk,
ISBN 978-1-47446-110-8, e-book, £90 hardback, £90
pre-order in paperback, £24.99
MEMAHAMI SEMANGAT HUKUM ISLAM
Authors: Mawaddah Rifqiyah 
Published: December 2022

Ketika Allah SWT. dan Rasul Muhammad SAW. menetapkan aturan-aturan hukum untuk umat manusia, sudah barang tentu hal tersebut memiliki maksud dan tujuan yang hendak dicapai. Dalam literatur hukum Islam, maksud dan tujuan hukum itu dikenal dengan istilah maqasid al-syari’ah. Melalui al-Qur’an—kitab yang turun kepada Nabi Muhammad SAW,—Allah SWT. menjelaskan secara universal maksud dan tujuan dari syari’ah sebagai Islamic Law itu sendiri, yakni, demi terwujudnya keselamatan dan kemaslahatan umat manusia, baik di dunia maupun di akhirat kelak. Al-Qur’an telah memproklamirkan diri sebagai sebagai kitab petunjuk dan rahmat bagi umat manusia. Ia juga menyatakan bahwa Nabi Muhammad SAW. diutus ke dunia untuk memberikan rahmat bagi alam semesta (rahmatan lil’alamin), dengan tujuan untuk menyempurnakan etika umat manusia di muka bumi ini.
METODE IJTIHAD DALAM HUKUM ISLAM: Studi Pemikiran K.H. Ali Yafie dan H. M. Atho’ Mudzhar
Authors: Amrullah Muh. Jazuli 
Published: December 2022

The emergence of new ideas in the realm of thought and method of ijtihad that done by the jurists in through ijtihad is a necessity. In the midst of the problems of human life increasingly complex, the role of religious leaders in particular is very important in addressing any problems that occur. In this context appears K.H. Ali Yafie and HM Atho 'Mudzhar, which has its own characteristics and patterns of thought in the development of Islamic law. Conceptually K.H. Ali Yafie and Atho 'Mudzhar offers ideas and methods that Islamic law could dialectic with social reality and social unrest. KH Ali Yafie maintain the classic methods of the previous scholars who contextualize the social reality as fard kifayah and fard 'ain, Nask mansukh. While H.M. Atho 'Mudzhar in thought and method of ijtihad, see a product of Islamic law not only of social reality, but also as a product of social history, as well as the influence of socio-political and socio-cultural. Implications of methods and ideas K.H. Ali Yafie is open mindset and thinking among Muslims, so that critical thinking and rational discourse to grow and thrive, while the implications of the method and thought HM Atho 'Mudzhar, for a mujtahid can not deny the history and influence of socio-cultural and socio-politics that surrounded it.