bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-interactive Boolean Searchable Asymmetric Encryption With Bilateral Access Control
Authors: Wang Xiwen , Zhang Kai , Li Jinguo , Wen Mi , Xu Shengmin , Ning Jianting 
Published: November 2022

Abstract
Searchable asymmetric encryption (SAE) enables a client to search over a data owner’s encrypted data. Nevertheless, state-of-the-art SAE schemes allow a data owner to specify access control policy for a client, while they have not considered the threat case of a malicious data owner. To address the problem, this work presents a non-interactive SAE scheme with bilateral access control: (i) allowing data owner and client to both specify policies toward the other party; (ii) allowing client to perform arbitrary boolean queries with sub-linear search complexity. Technically, we extend Cash et al.’s highly scalable SSE into an asymmetric setting and introduce the property of data owner authenticity. By refining identity-based matchmaking encryption, we formalize the syntax and security definition of our SAE with identity-based bilateral access control. Moreover, the security of the proposed SAE can be reduced to discrete logistic assumption and decisional bilinear Diffie–Hellman assumption. As an enhanced extension, we present a non-interactive multi-client SAE scheme with fuzzy identity-based bilateral access control. In addition, we implement the proposed schemes in real cloud platform and evaluate their performance on a real-world dataset. The result confirms that our SAE schemes achieve bilateral access control for both data owner and client with highly acceptable efficiency.
The effect of a game-based mobile app ‘MyHeartMate’ to promote lifestyle change in coronary disease patients: a randomized controlled trial
Authors: Gallagher Robyn , Chow Clara K , Parker Helen , Neubeck Lis , Celermajer David S , Redfern Julie , Tofler Geoffrey , Buckley Thomas , Schumacher Tracy , Hyun Karice , Boroumand Farzaneh , Figtree Gemma 
Published: November 2022

Abstract

Aims
Secondary prevention reduces coronary heart disease (CHD) progression. Traditional prevention programs including cardiac rehabilitation are under-accessed, which smartphone apps may overcome. To evaluate the effect of a game-based mobile app intervention (MyHeartMate) to improve cardiovascular risk factors and lifestyle behaviours.

Methods and results
Single-blind randomized trial of CHD patients in Sydney, 2017–2021. Intervention group were provided the MyHeartMate app for 6 months. Co-designed features included an avatar of the patient’s heart and tokens earned by risk factor work (tracking, challenges, and quizzes). The control group received usual care. Primary outcome was self-reported physical activity [metabolic equivalents (METs), Global Physical Activity Questionnaire] and secondary outcomes included lipid levels, blood pressure (BP), body mass index, and smoking. Pre-specified sample size was achieved (n = 390), age 61.2 ± 11.5 years; 82.5% men and 9.2% current smokers. At 6 months, adjusted for baseline levels, the intervention group achieved more physical activity than control (median difference 329 MET mins/wk), which was not statistically significant (95% CI −37.4, 696; P = 0.064). No differences occurred between groups on secondary outcomes except for lower triglyceride levels in the intervention [mean difference −0.3 (95% CI −0.5, −0.1 mmoL/L, P = 0.004)]. Acceptability was high: 94.8% of intervention participants engaged by tracking exercise or BP and completing missions; 26.8% continued to engage for ≥30 days. Participants (n = 14) reported the app supported tracking behaviours and risk factors, reinforcing and improving self-care confidence, and decreasing anxiety.

Conclusion
A game-based app proved highly acceptable for patients with CHD but did not improve risk factors or lifestyle behaviours other than triglyceride levels.
The Kähler–Ricci Flow With Log Canonical Singularities
Authors: Chau Albert , Ge Huabin , Li Ka-Fai , Shen Liangming 
Published: November 2022

Abstract
We establish the existence of the Kähler–Ricci flow on projective varieties with log canonical singularities. This generalizes some of the existence results of Song–Tian [36] in case of projective varieties with klt singularities. We also prove that the normalized Kähler–Ricci flow will converge to the Kähler–Einstein metric with negative Ricci curvature on semi-log canonical models in the sense of currents. Finally, we also construct Kähler–Ricci flow solutions performing divisorial contractions and flips with log canonical singularities.
Famine, Inequality, and Conflict
Authors: Meriläinen Jaakko , Mitrunen Matti , Virkola Tuomo 
Published: November 2022

Abstract
This paper employs newly collected historical data from Finland to present evidence of historically contingent, long-run consequences of a famine. We document high levels of local inequality in terms of income and land distribution until a violent uprising in 1918. These inequalities partly originated from the famine of 1866–1868, which increased the concentration of land and power to large landowners. We further show that regions with more exposure to the famine had more labor coercion by the early 1900s. These inner tensions led to violent conflict following the Russian Revolution and the Finnish independence from the Russian Empire. Using microdata on all the casualties of the 1918 Finnish Civil War, we demonstrate that the famine plausibly contributed to local insurgency participation through these factors. Although unsuccessful in replacing the government, the insurgency led to significant policy changes, including radical land redistribution and a full extension of the franchise. These national reforms led to a more drastic shift toward equality in locations more affected by the famine with greater pre-conflict inequality. Our findings highlight how historical shocks can have large and long-lasting, but not straightforward impacts.
The Regulation of Hazardous Substances and Activities During Warfare
Authors: de Hemptinne Jérôme 
Published: November 2022

Abstract
Although hazardous activities and substances create significant environmental risks and damage during warfare, international humanitarian law contains very few provisions that specifically address this question. To reinforce the protection of the environment, these provisions should be interpreted in light of — and complemented by — international environmental instruments adopted during the last decades. Indeed, these instruments envisage important rules, mechanisms, and institutions which aim at preventing and redressing environmental threats and damage resulting from the production and use of hazardous substances and the dumping of wastes during peacetime. This article seeks precisely to examine how these rules, mechanisms and institutions could apply in the context of war-related incidents, not only during an armed conflict, but also before and after its occurrence. The article will show that sophisticated safety measures that help in preventing such incidents, which often create irreversible consequences, must be designed, tested, and implemented well before hostilities are taking place. Furthermore, environmental remediation of contaminated areas should also be considered after the end of the conflict.
On algebraic and topological semantics of the modal logic of common knowledge S4CI
Authors: Shamkanov Daniyar 
Published: November 2022

AbstractFor the modal logic $\textsf {S4}^{C}_{I}$, we identify the class of completable $\textsf {S4}^{C}_{I}$-algebras and prove for them a Stone-type representation theorem. As a consequence, we obtain strong algebraic and topological completeness of the logic $\textsf {S4}^{C}_{I}$ in the case of local semantic consequence relations. In addition, we consider an extension of the logic $\textsf {S4}^{C}_{I}$ with certain infinitary derivations and establish the corresponding strong completeness results for the enriched system in the case of global semantic consequence relations.
Law Applicable
Authors: Bork Reinhard 
Published: November 2022

AbstractThis chapter explains which laws should a jurisdiction court apply in particular circumstances amidst cross-border proceedings. It also notes the general rule and application in applying the law of another Member State while also covering the exceptions, rationales, and commonalities of the law governing insolvency proceedings. The system is required to be uniform and comprehensive while simultaneously covering procedural and substantive law. In line with EIR’s Article Seven, the rule of lex fori concurus coincides with private international law and the law applicable to insolvency proceedings. Moreover, the unclear boundaries of insolvency law remain a major issue when using international jurisdictions determined by the COMI and the applicable law of the insolvency proceedings.
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger
Authors: Hata Keiichi , Kobayashi Naohiro , Sugimura Keita , Qin Weihua , Haxholli Deis , Chiba Yoshie , Yoshimi Sae , Hayashi Gosuke , Onoda Hiroki , Ikegami Takahisa , Mulholland Christopher B , Nishiyama Atsuya , Nakanishi Makoto , Leonhardt Heinrich , Konuma Tsuyoshi , Arita Kyohei 
Published: November 2022

Abstract
Ubiquitin-like with PHD and RING finger domain-containing protein 1 (UHRF1)-dependent DNA methylation is essential for maintaining cell fate during cell proliferation. Developmental pluripotency-associated 3 (DPPA3) is an intrinsically disordered protein that specifically interacts with UHRF1 and promotes passive DNA demethylation by inhibiting UHRF1 chromatin localization. However, the molecular basis of how DPPA3 interacts with and inhibits UHRF1 remains unclear. We aimed to determine the structure of the mouse UHRF1 plant homeodomain (PHD) complexed with DPPA3 using nuclear magnetic resonance. Induced α-helices in DPPA3 upon binding of UHRF1 PHD contribute to stable complex formation with multifaceted interactions, unlike canonical ligand proteins of the PHD domain. Mutations in the binding interface and unfolding of the DPPA3 helical structure inhibited binding to UHRF1 and its chromatin localization. Our results provide structural insights into the mechanism and specificity underlying the inhibition of UHRF1 by DPPA3.
Intelligent indoor metasurface robotics
Authors: Zhao Hanting , Hu Shengguo , Zhang Hongrui , Wang Zhuo , Dong Hao , del Hougne Philipp , Cui Tie Jun , Li Lianlin 
Published: November 2022

ABSTRACTIntelligent indoor robotics is expected to rapidly gain importance in crucial areas of our modern society such as at-home health care and factories. Yet, existing mobile robots are limited in their ability to perceive and respond to dynamically evolving complex indoor environments because of their inherently limited sensing and computing resources that are, moreover, traded off against their cruise time and payload. To address these formidable challenges, here we propose intelligent indoor metasurface robotics (I2MR), where all sensing and computing are relegated to a centralized robotic brain endowed with microwave perception; and I2MR’s limbs (motorized vehicles, airborne drones, etc.) merely execute the wirelessly received instructions from the brain. The key aspect of our concept is the centralized use of a computation-enabled programmable metasurface that can flexibly mold microwave propagation in the indoor wireless environment, including a sensing and localization modality based on configurational diversity and a communication modality to establish a preferential high-capacity wireless link between the I2MR’s brain and limbs. The metasurface-enhanced microwave perception is capable of realizing low-latency and high-resolution three-dimensional imaging of humans, even around corners and behind thick concrete walls, which is the basis for action decisions of the I2MR’s brain. I2MR is thus endowed with real-time and full-context awareness of its operating indoor environment. We implement, experimentally, a proof-of-principle demonstration at ∼2.4 GHz, in which I2MR provides health-care assistance to a human inhabitant. The presented strategy opens a new avenue for the conception of smart and wirelessly networked indoor robotics.
Activating sulfur oxidation reactionviasix-electron redox mesocrystal NiS2 for sulfur-based aqueous batteries
Authors: Yang Zhoudong , Wang Boya , Chen Yongjin , Zhou Wanhai , Li Hongpeng , Zhao Ruizheng , Li Xinran , Zhang Tengsheng , Bu Fanxing , Zhao Zaiwang , Li Wei , Chao Dongliang , Zhao Dongyuan 
Published: November 2022

ABSTRACTSulfur-based aqueous batteries (SABs) are deemed promising candidates for safe, low-cost, and high-capacity energy storage. However, despite their high theoretical capacity, achieving high reversible value remains a great challenge due to the thermodynamic and kinetics problems of elemental sulfur. Here, the reversible six-electron redox electrochemistry is constructed by activating the sulfur oxidation reaction (SOR) process of the elaborate mesocrystal NiS2 (M-NiS2). Through the unique 6e− solid-to-solid conversion mechanism, SOR efficiency can reach an unprecedented degree of ca. 96.0%. The SOR efficiency is further revealed to be closely associated with the kinetics feasibility and thermodynamic stability of the M-NiS2 intermedium in the formation of elemental sulfur. Benefiting from the boosted SOR, compared with the bulk electrode, the M-NiS2 electrode exhibits a high reversible capacity (1258 mAh g−1), ultrafast reaction kinetics (932 mAh g−1 at 12 A g−1), and long-term cyclability (2000 cycles at 20 A g−1). As a proof of concept, a new M-NiS2‖Zn hybrid aqueous battery exhibits an output voltage of 1.60 V and an energy density of 722.4 Wh kgcath−1, which opens a new opportunity for the development of high-energy aqueous batteries.
Effective transport network driven by tortuosity gradient enables high-electrochem-active solid-state batteries
Authors: Liu Qing-Song , An Han-Wen , Wang Xu-Feng , Kong Fan-Peng , Sun Ye-Cai , Gong Yu-Xin , Lou Shuai-Feng , Shi Yi-Fan , Sun Nan , Deng Biao , Wang Jian , Wang Jia-Jun 
Published: November 2022

ABSTRACT
Simultaneously achieving high electrochemical activity and high loading for solid-state batteries has been hindered by slow ion transport within solid electrodes, in particular with an increase in electrode thickness. Ion transport governed by ‘point-to-point’ diffusion inside a solid-state electrode is challenging, but still remains elusive. Herein, synchronized electrochemical analysis using X-ray tomography and ptychography reveals new insights into the nature of slow ion transport in solid-state electrodes. Thickness-dependent delithiation kinetics are spatially probed to identify that low-delithiation kinetics originate from the high tortuous and slow longitudinal transport pathways. By fabricating a tortuosity-gradient electrode to create an effective ion-percolation network, the tortuosity-gradient electrode architecture promotes fast charge transport, migrates the heterogeneous solid-state reaction, enhances electrochemical activity and extends cycle life in thick solid-state electrodes. These findings establish effective transport pathways as key design principles for realizing the promise of solid-state high-loading cathodes.
An Elastic Net Regression Model for Identifying Long COVID Patients Using Health Administrative Data: A Population-Based Study
Authors: Binka Mawuena , Klaver Braeden , Cua Georgine , Wong Alyson W , Fibke Chad , Velásquez García Héctor A , Adu Prince , Levin Adeera , Mishra Sharmistha , Sander Beate , Sbihi Hind , Janjua Naveed Z 
Published: November 2022

Abstract

Background
Long coronavirus disease (COVID) patients experience persistent symptoms after acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Healthcare utilization data could provide critical information on the disease burden of long COVID for service planning; however, not all patients are diagnosed or assigned long COVID diagnostic codes. We developed an algorithm to identify individuals with long COVID using population-level health administrative data from British Columbia (BC), Canada.

Methods
An elastic net penalized logistic regression model was developed to identify long COVID patients based on demographic characteristics, pre-existing conditions, COVID-19-related data, and all symptoms/conditions recorded &gt;28–183 days after the COVID-19 symptom onset/reported (index) date of known long COVID patients (n = 2430) and a control group (n = 24 300), selected from all adult COVID-19 cases in BC with an index date on/before October 31, 2021 (n = 168 111). Known long COVID cases were diagnosed in a clinic and/or had the International Classification of Diseases, Tenth Revision, Canada (ICD-10-CA) code for “post COVID-19 condition” in their records.

Results
The algorithm retained known symptoms/conditions associated with long COVID, demonstrating high sensitivity (86%), specificity (86%), and area under the receiver operator curve (93%). It identified 25 220 (18%) long COVID patients among the remaining 141 381 adult COVID-19 cases, &gt;10 times the number of known cases. Known and predicted long COVID patients had comparable demographic and health-related characteristics.

Conclusions
Our algorithm identified long COVID patients with a high level of accuracy. This large cohort of long COVID patients will serve as a platform for robust assessments on the clinical course of long COVID, and provide much needed concrete information for decision-making.
Rapid onset and unpredicted findings of a giant nodular melanoma arising on a congenital nevus: a case report
Authors: Mallouhy Alin , Kounsselie Edwar , Bitar Amira , Makhoul Ebrahim , Al-janabi Moatasem Hussein , Alshehabi Zuheir , Georgeos Michael 
Published: November 2022

ABSTRACTMelanoma is a malignancy that develops from pigment-producing cells known as melanocytes. Although it is considered one of the most fatal tumors in the world, its early diagnosis is associated with a better prognosis and overall survival. A 49-year-old man was admitted to the dermatology department with a 15 cm lesion on the left arm. It was growing on a congenital nevus to reach an enormous size. Surgical excision was not possible and the treatment was controversial as the patient showed unpredicted resistance to immunotherapy. Further evaluations revealed false-negative BRAF mutation, which completely changed the course of treatment. Cutaneous melanoma is a rare malignancy, accounting only for 1% of skin cancer cases, and having it arising on a pre-existing congenital nevus is even much rarer. Although there is no decisive definition of giant melanoma, some authors define it as a lesion of more than 10 cm in diameter. Through the literature, only a few cases of giant melanoma on the arm have been reported. Through our paper, we are revealing the importance of early diagnosis and treatment of melanoma and confirming the significant role of regular follow-up for patients with a congenital melanocytic nevus. Moreover, we are showing the importance of having alternative methods for detecting BRAF mutations to avoid false-negative results and have better outcomes.
Management of Lung Cancer in the Patient with Interstitial Lung Disease
Authors: Frank Angela J , Dagogo-Jack Ibiayi , Dobre Ioana A , Tait Sarah , Schumacher Lana , Fintelmann Florian J , Fingerman Leah M , Keane Florence K , Montesi Sydney B 
Published: November 2022

Abstract
Patients with interstitial lung disease (ILD), especially those with pulmonary fibrosis, are at increased risk of developing lung cancer. Management of lung cancer in patients with ILD is particularly challenging. Diagnosis can be complicated by difficulty differentiating lung nodules from areas of focal fibrosis, and percutaneous biopsy approaches confer an increased risk of complications in those with pulmonary fibrosis. Lung cancer treatment in these patients pose several specific considerations. The degree of lung function impairment may preclude lobectomy or surgical resection of any type. Surgical resection can trigger an acute exacerbation of the underlying ILD. The presence of ILD confers an increased risk of pneumonitis with radiotherapy, and many of the systemic therapies also carry an increased risk of pneumonitis in this population. The safety of immunotherapy in the setting of ILD remains to be fully elucidated and concerns remain as to triggering pneumonitis. The purpose of this review is to summarize the evidence regarding consideration for tissue diagnosis, chemotherapy and immunotherapy, radiotherapy, and surgery, in this patient population and discuss emerging areas of research. We also propose a multidisciplinary approach and practical considerations for monitoring for ILD progression during lung cancer treatment.
Phase Ib Study of Ulixertinib Plus Gemcitabine and Nab-Paclitaxel in Patients with Metastatic Pancreatic Adenocarcinoma
Authors: Grierson Patrick M , Tan Benjamin , Pedersen Katrina S , Park Haeseong , Suresh Rama , Amin Manik A , Trikalinos Nikolaos A , Knoerzer Deborah , Kreider Brent , Reddy Anupama , Liu Jingxia , Der Channing J , Wang-Gillam Andrea , Lim Kian-Huat 
Published: November 2022

Abstract

Background
Ulixertinib is a novel oral ERK inhibitor that has shown promising single-agent activity in a phase I clinical trial that included patients with RAS-mutant cancers.

Methods
We conducted a phase Ib trial combining ulixertinib with gemcitabine and nab-paclitaxel (GnP) for untreated metastatic pancreatic adenocarcinoma. The trial comprised a dose de-escalation part and a cohort expansion part at the recommended phase II dose (RP2D). Primary endpoint was to determine the RP2D of ulixertinib plus GnP and secondary endpoints were to assess toxicity and safety profile, biochemical and radiographic response, progression-free survival (PFS) and overall survival (OS).

Results
Eighteen patients were enrolled. Ulixertinib 600 mg PO twice daily (BID) with GnP was initially administered but was de-escalated to 450 mg BID as RP2D early during dose expansion due to poor tolerability, which ultimately led to premature termination of the study. Common treatment-related adverse events (TRAEs) were anemia, thrombocytopenia, rash and diarrhea. For 5 response evaluable patients, one patient achieved a partial response and 2 patients achieved stable disease. For 15 patients who received the triplet, median PFS and OS were 5.46 and 12.23 months, respectively.

Conclusion
Ulixertinib plus GnP had similar frequency of grade ≥3 TRAEs and potentially efficacy as GnP, however was complicated by a high rate of all-grade TRAEs (ClinicalTrials.gov Identifier: NCT02608229).