bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relación de las Habilidades Sociales con el rendimiento académico en estudiantes Universitarios
Authors: Cosio Herbert , Núñez Miguel , Lazo Liceth 
Published: January 2022

Él objetivo fue establecer la relación de las Habilidades Sociales y el Rendimiento Académico de los estudiantes universitarios. La investigación se desarrolló dentro del paradigma cuantitativo, se utilizó el método deductivo, de alcance relacional y analítico. La unidad de análisis estuvo constituido por estudiantes de la universidad Andina de Cusco. La muestra estuvo constituido por 201 estudiantes, mediante un muestreo probabilístico aleatorio simple. La prueba de hipótesis fue contratada mediante el estadístico paramétrico de correlación de Pearson. El resultado obtenido fue a mayores habilidades sociales, mayor el rendimiento académico en los estudiantes, se obtuvo una correlación de Pearson de 0,829 con un factor de determinación del 68,6%. Se concluye que existe asociación directamente proporcional entre las Habilidades Sociales y rendimiento académico de los estudiantes de Medicina Humana de la Universidad Andina de Cusco.
Combined Surfactant and Enzyme-Assisted Extraction of Pectin from Hawthorn (Crataegus monogyna Jacq.) Fruits
Authors: Novikova Anastasia , Skrypnik Liubov 
Published: January 2022

Introduction. Commercial pectin is usually obtained from apples or citrus fruits. However, some wild fruits, such as hawthorn, are also rich in pectin with valuable nutritional and medical properties. The research objective was to study and improve the process of combined surfactant and enzyme-assisted extraction of pectin from hawthorn fruits.
Study objects and methods. The study involved a 1% solution of Polysorbate-20 surfactant and a mix of two enzymes, namely cellulase and xylanase, in a ratio of 4:1. The response surface methodology with the Box-Behnken experimental design improved the extraction parameters. The experiment featured three independent variables – temperature, time, and solvent-to-material ratio. They varied at three levels: 20, 40, and 60°C; 120, 180, and 240 min; 15, 30, and 45 mL per g. Their effect on the parameters on the pectin yield was assessed using a quadratic mathematical model based on a second order polynomial equation.
Results and discussion. The response surface methodology made it possible to derive a second order polynomial regression equation that illustrated the effect of extraction parameters on the yield of polyphenols. The regression coefficient (R2 = 98.14%) and the lack-of-fit test (P > 0.05) showed a good accuracy of the model. The optimal extraction conditions were found as follows: temperature = 41°C, time = 160 min, solvent-to-material ratio = 32 mL per 1 g. Under the optimal conditions, the predicted pectin yield was 14.9%, while the experimental yield was 15.2 ± 0.4%. The content of galacturonic acid in the obtained pectin was 58.5%, while the degree of esterification was 51.5%. The hawthorn pectin demonstrated a good complex-building ability in relation to ions of copper (564 mg Cu2+/g), lead (254 mg Pb2+/g), and cobalt (120 mg Co2+/g).
Conclusion. Combined surfactant and enzyme-assisted extraction made improved the extraction of pectin from hawthorn fruits. The hawthorn pectin can be used to develop new functional products.
Fermented Milk Beverages Fortified with Soy Protein
Authors: Statsenko Ekaterina , Litvinenko Oksana , Kodirova Galina , Kubankova Galina , Korneva Nadezhda , Pokotilo Olesya 
Published: January 2022

Introduction. Fermented milk beverages with various vegetable additives expand the range of functional foods with probiotics, vitamins, and minerals. The research objective was to develop a new technology for fermented milk drinks fortified with soy protein.
Study objects and methods. Heat-treated cow’s milk with Direct Vat Set bacterial starter served as the control sample, while the experimental samples featured fermented milk fortified with soy additives. The soy protein ingredient was obtained from powdered sprouted soybean. Soybeans were pre-germinated in a thermostat at 26°C for 24 h and blanched with steam for 15 min. After that, 1–9% of the soy substance was added to pasteurized milk and fermented at 38–40°C for 6–8 h. The resulting sample was tested for quality indicators and physicochemical composition.
Results and discussion. The best sensory properties belonged to the sample with 5% mass fraction of the soy additive. As a result, the soy-fortified beverages entitled Bifivit and Immunovit had a better nutritional value: protein – by 1.92 and 1.79 g, fat – by 0.77 and 0.75 g, vitamin E – by 0.16 mg, choline – by 23.82 mg, potassium – by 149 mg, phosphorus – by 19 and 22 mg, calcium – by 25 and 24 mg, magnesium – by 22 and 23 mg, respectively. One portion (100 g) of these drinks contained over 15% of recommended daily intake of protein, vitamin B2, potassium, magnesium, calcium, and phosphorus. The content of lactic acid and bifidobacteria remained above the norm (1×108) both in fresh products and by the end of their shelf life.
Conclusion. The article introduces a technology of new functional soy-fortified fermented milk drinks with improved chemical and sensory properties.
Effect of Oat-Based Ingredients on the Quality of Pastry Products
Authors: Shcherbakova Natalia , Misteneva Svetlana , Rudenko Oxana , Kondrat’ev Nikolay , Baskakov Andrew 
Published: January 2022

Introduction. Whole grain products can prevent some chronic diseases. Oats and oat-based foods are rich in beta-glucan, which makes them a perfect ingredient for functional foods. The present research objective was to introduce oat-based ingredients into the formulation of sugar cookies and study the quality of the finished product.
Study objects and methods. The study involved various formulations of sugar cookies with different proportions of oat meal and composite flour. Sensory, physicochemical, rheological, structural, and mechanical properties were determined according to standard methods.
Results and discussion. The mass shares of protein, fat, and dietary fiber increased together with the share of oat meal: protein – 11.9–12.5%, fat – 2.3–3.7%, dietary fiber – 4.1–4.5%. The swelling rates were 3.41–4.60, which was higher than in the wheat flour sample (2.94). Oat meal increased the viscosity of the model suspensions from 50 to 500 Pa·s The sample with the biggest share of oat meal had the greatest strength (1700 g). The water absorption also increased (193%): it was 220 when the share of oat meal was 20% and 221% when it was 30%. Oat meal decreased the water activity from 0.360 to 0.290 as its concentration grew.
Conclusion. The optimal amount of oat meal was 30% and that of oatmeal flakes – 10% of the flour amount. The research also defined the effect of oat meal and oat flakes on the composite flour blend, model dough, and sugar cookes. The article introduces a new commercial formulation of sugar biscuits.
Adsorption of phosphorus onto nanoscale zero-valent iron/activated carbon: removal mechanisms, thermodynamics, and interferences
Authors: Adly Adel , Mostafa Nagwan G. , Elawwad Abdelsalam 
Published: January 2022

Abstract
This study investigated removal mechanisms, thermodynamics, and interferences of phosphorus adsorption onto nanoscale zero-valent iron (nZVI)/activated carbon composite. Activated carbon was successfully used as support for nZVI particles to overcome shortcomings of using nZVI include its tendency to aggregate and separation difficulties. A comprehensive characterization was done for the composite particles, which revealed a high specific surface area of 72.66 m2/g and an average particle size of 37 nm. Several adsorption isotherms and kinetic models have been applied to understand the removal mechanisms. Adsorption isotherm is best fitted by Freundlich and Langmuir models, which indicates that the estimated maximum phosphorus adsorption capacity is 53.76 mg/g at pH 4. Adsorption kinetics showed that the chemisorption process behaved according to a pseudo-second-order model. An adsorption mechanism study conducted using the intra-particle diffusion and Boyd kinetic models indicated that the adsorption rate is limited by surface diffusion. A thermodynamic study showed that phosphorus removal efficiency increased as the solution temperature increased from 15 to 37 °C. Finally, the results of an interference study showed that the presence of Ni2+, Cu2+, Ca2+, Na+ cations, nitrate ions (), and sodium acetate improves removal efficiency, while the presence of sulfate ions () and urea reduces removal efficiency.
Chemical Constituents of the Roots of Astragalus polycladus var. nigrescens
Authors: Zhang Yu , Yang Han , Dong Xiang , Xiao Chao-Jiang , Jiang Bei 
Published: January 2022

Abstract:
A new cycloartane triterpenoid, 24-acetylcyclocantogenin (1), along with five cycloartane
triterpenoids (2-6), eight steroids (7-14) and nine other known compounds (15-23), was obtained from
the methanol extract of roots of Astragalus polycladus var. nigrescens. Their structures were elucidated
based on extensive spectroscopic analysis (1D and 2D-NMR, MS and IR). They were isolated from A.
polycladus var. nigrescens for the first time.
2′,7′-Dichlorofluorescein: Biological, Analytical, and Industrial Progress
Authors: Kousar Shazia , Mudassir Muhammad Ahmad , Bibi Fehmeeda , Irfan Madiha , Alyas Mohammad , Bukhari Syed Waqas , Qadir Salman 
Published: January 2022

Abstrack:
Fluorescein derivatives have attracted a great deal of attention for ubiquitous applications
on account of their unique properties. Particularly, the 2′,7′-dichlorofluorescein (DCF) is of paramount
importance in biological, analytical, and industrial fields. Mainly, DCF has been employed as
a reactant in reactive oxygen species (ROS) formation reactions in biological applications. It has
been utilized in oxidative stress and cell spreading measurement. It has been extensively explored to
analyze oxidative, respiratory burst, secretory peroxidase, and multidrug resistance-associated proteins
(MRPs). It has been widely investigated for detecting/quantification of H2O2, glucose, lipid,
cholesterol, other hydroperoxides, and polycationic protamine.
Moreover, it has been applied to differentiate dopamine from ascorbic acid. It has also shown immense
potential in biolabeling, cancer imaging, and drug delivery. Several studies demonstrated the
great promise of DCF as a fluorescent probe for real-time monitoring/quantification of mercury,
cadmium, zinc, arsenite, acetate, fluoride, thiocyanate, azide ions, hydrogen peroxide, ammonia,
ozone, sulfur dioxide, and drug molecules. Furthermore, the use of DCF to manufacture dyesensitized
solar cells and Schottky barrier devices opens up avenues for its industrial applications.
Apart from presenting a comprehensive account of the immense potential of DCF in the areas mentioned
above, the present review also intends to provide insight into its broader future scope for a
myriad of applications to emerge.
Developing high-quality human resources in quang ngai province (Viet Nam) currently
Authors: Quyet Nguyen Thi 
Published: January 2022

Currently, developing the high-quality human resources to meet the socio-economic development requirements of Vietnam in general and Quang Ngai province in particular is a very urgent need, is a very urgent need. This is a both fundamental and long-term issue in order to realize the strong and happy national aspirations. Located in the central key economic region with Dung Quat economic zone whose core is Dung Quat oil refinery, Quang Ngai is developing day by day. Presently, Dung Quat economic zone together with industrial clusters of the province have been creating a huge value of industrial output, especially heavy industry - an important spearhead industry in the process of industrialization, modernization, creating momentum to promote the development of industry and service in the whole region, and play an important role in creating the driving force for the development of the central region. Due to the specific requirements of industries with modern technology, Quang Ngai is required to have highly qualified and skilled human resources. Being well aware of this, Quang Ngai province has paid great attention to the development of high-quality human resources and initially achieved certain achievements over the past time.
Using Facebook Advertisements for Women’s Health Research: Methodology and Outcomes of an Observational Study
Authors: Farr Deeonna E , Battle Darian A , Hall Marla B 
Published: January 2022

Background
Recruitment of diverse populations for health research studies remains a challenge. The COVID-19 pandemic has exacerbated these challenges by limiting in-person recruitment efforts and placing additional demands on potential participants. Social media, through the use of Facebook advertisements, has the potential to address recruitment challenges. However, existing reports are inconsistent with regard to the success of this strategy. Additionally, limited information is available about processes that can be used to increase the diversity of study participants.

Objective
A Qualtrics survey was fielded to ascertain women’s knowledge of and health care experiences related to breast density. This paper describes the process of using Facebook advertisements for recruitment and the effectiveness of various advertisement strategies.

Methods
Facebook advertisements were placed in 2 rounds between June and July 2020. During round 1, multiple combinations of headlines and interest terms were tested to determine the most cost-effective advertisement. The best performing advertisement was used in round 2 in combination with various strategies to enhance the diversity of the survey sample. Advertisement performance, cost, and survey respondent data were collected and examined.

Results
In round 1, a total of 45 advertisements with 5 different headlines were placed, and the average cost per link click for each headline ranged from US $0.12 to US $0.79. Of the 164 women recruited in round 1, in total 91.62% were eligible to complete the survey. Advertisements used during recruitment in round 2 resulted in an average cost per link click of US $0.11. During the second round, 478 women attempted the survey, and 87.44% were eligible to participate. The majority of survey respondents were White (80.41%), over the age of 55 years (63.94%), and highly educated (63.71%).

Conclusions
Facebook advertisements can be used to recruit respondents for health research quickly, but this strategy may yield participants who are less racially diverse, more educated, and older than the general population. Researchers should consider recruiting participants through other methods in addition to creating Facebook advertisements targeting underrepresented populations.
A Novel Experience Sampling Method Tool Integrating Momentary Assessments of Cognitive Biases: Two Compliance, Usability, and Measurement Reactivity Studies
Authors: Boemo Teresa , Socastro Angela , Blanco Ivan , Martin-Garcia Oscar , Pacheco-Romero Ana Mar , Rodríguez-Carvajal Raquel , Sanchez-Lopez Alvaro 
Published: January 2022

Background
Experience sampling methods (ESMs) are increasingly being used to study ecological emotion dynamics in daily functioning through repeated assessments taken over several days. However, most of these ESM approaches are only based on self-report assessments, and therefore, studies on the ecological trajectories of their underlying mechanisms are scarce (ie, cognitive biases) and require evaluation through experimental tasks. We developed a novel ESM tool that integrates self-report measures of emotion and emotion regulation with a previously validated app-based cognitive task that allows for the assessment of underlying mechanisms during daily functioning.

Objective
The objective of the study is to test this new tool and study its usability and the possible factors related to compliance with it in terms of latency and missing responses. Among the compliance predictors, we considered psychological and time-related variables, as well as usability, measurement reactivity, and participants’ satisfaction with the tool.

Methods
We conducted 2 extensive ESM studies—study 1 (N=84; a total of 3 assessments per day for 5 days) and study 2 (N=135; a total of 3 assessments per day for 10 days).

Results
In both studies, participants found the tool highly usable (average usability score >81). By using mixed regression models, we found both common and specific results for the compliance predictors. In both study 1 and study 2, latency was significantly predicted by the day (P<.001 and P=.003, respectively). Participants showed slower responses to the notification as the days of the study progressed. In study 2 but not in study 1, latency was further predicted by individual differences in overload with the use of the app, and missing responses were accounted for by individual differences in stress reactivity to notifications (P=.04). Thus, by using a more extensive design, participants who experienced higher overload during the study were characterized by slower responses to notifications (P=.01), whereas those who experienced higher stress reactivity to the notification system were characterized by higher missing responses.

Conclusions
The new tool had high levels of usability. Furthermore, the study of compliance is of enormous importance when implementing novel ESM methods, including app-based cognitive tasks. The main predictors of latency and missing responses found across studies, specifically when using extensive ESM protocols (study 2), are methodology-related variables. Future research that integrates cognitive tasks in ESM designs should take these results into consideration by performing accurate estimations of participants’ response rates to facilitate the optimal quality of novel eHealth approaches, as in this study.
Mobile App Intervention on Reducing the Myeloproliferative Neoplasm Symptom Burden: Pilot Feasibility and Acceptability Study
Authors: Win Hninyee , Russell Samantha , Wertheim Betsy C , Maizes Victoria , Crocker Robert , Brooks Audrey J , Mesa Ruben , Huberty Jennifer , Geyer Holly , Eckert Ryan , Larsen Ashley , Gowin Krisstina 
Published: January 2022

Background
Myeloproliferative neoplasms (MPNs) are a group of myeloid malignancies associated with significant symptom burden. Despite pharmacological advances in therapies, inadequate management of MPN symptoms results in reduced quality of life.

Objective
This study aims to determine the feasibility of a 12-week global wellness mobile app intervention in decreasing MPN symptom burden. The University of Arizona Andrew Weil Center for Integrative Medicine’s global wellness mobile app, My Wellness Coach (MWC), guides patients to improve their health and well-being through facilitating behavior changes.

Methods
Of the 30 patients enrolled in a 12-week intervention, 16 (53%) were retained through the final assessment. Feasibility was assessed by the ease of recruitment, participant adherence, and mobile app acceptability. App acceptability was measured using the user version of the Mobile Application Rating Scale. MPN symptom burden was measured at baseline and 12 weeks after the intervention.

Results
Recruitment was efficient, with the participant goal reached within a 60-day period, suggestive of a demand for such an intervention. Adherence was less than the target within study design (75%), although similar to mobile device app use in other studies (53%). The app was deemed acceptable based on the mean user version of the Mobile Application Rating Scale 3-star rating by participants. Finally, there were statistically significant improvements in several MPN symptoms, quality of life, and total score on the Myeloproliferative Neoplasm Symptom Assessment Form surveys.

Conclusions
Our 12-week intervention with the MWC app was feasible and was associated with a decrease in MPN symptom burden. Further investigation of the MWC app for use as a self-management strategy to reduce the symptom burden in patients with MPN is warranted.
The Cole Relaxation Frequency as a Parameter to Identify Cancer in Lung Tissue: Preliminary Animal and Ex Vivo Patient Studies
Authors: Bogdanowicz Les , Fidaner Onur , Ceres Donato , Grycuk Alexander , Guidetti Martina , Demos David 
Published: January 2022

Background
Lung cancer is the world’s leading cause of cancer deaths, and diagnosis remains challenging. Lung cancer starts as small nodules; early and accurate diagnosis allows timely surgical resection of malignant nodules while avoiding unnecessary surgery in patients with benign nodules.

Objective
The Cole relaxation frequency (CRF) is a derived electrical bioimpedance signature, which may be utilized to distinguish cancerous tissues from normal tissues.

Methods
Human testing ex vivo was conducted with NoduleScan in freshly resected lung tissue from 30 volunteer patients undergoing resection for nonsmall cell lung cancer. The CRF of the tumor and the distant normal lung tissue relative to the tumor were compared to histopathology specimens to establish a potential algorithm for point-of-care diagnosis. For animal testing in vivo, 20 mice were implanted with xenograft human lung cancer tumor cells injected subcutaneously into the right flank of each mouse. Spectral impedance measurements were taken on the tumors on live animals transcutaneously and on the tumors after euthanasia. These CRF measurements were compared to healthy mouse lung tissue. For porcine lung testing ex vivo, porcine lungs were received with the trachea. After removal of the vocal box, a ventilator was attached to pressurize the lung and simulate breathing. At different locations of the lobes, the lung's surface was cut to produce a pocket that could accommodate tumors obtained from in vivo animal testing. The tumors were placed in the subsurface of the lung, and the electrode was placed on top of the lung surface directly over the tumor but with lung tissue between the tumor and the electrode. Spectral impedance measurements were taken when the lungs were in the deflated state, inflated state, and also during the inflation-deflation process to simulate breathing.

Results
Among 60 specimens evaluated in 30 patients, NoduleScan allowed ready discrimination in patients with clear separation of CRF in tumor and distant normal tissue with a high degree of sensitivity (97%) and specificity (87%). In the 25 xenograft small animal model specimens measured, the CRF aligns with the separation observed in the human in vivo measurements. The CRF was successfully measured of tumors implanted into ex vivo porcine lungs, and CRF measurements aligned with previous tests for pressurized and unpressurized lungs.

Conclusions
As previously shown in breast tissue, CRF in the range of 1kHz-10MHz was able to distinguish nonsmall cell lung cancer versus normal tissue. Further, as evidenced by in vivo small animal studies, perfused tumors have the same CRF signature as shown in breast tissue and human ex vivo testing. Inflation and deflation of the lung have no effect on the CRF signature. With additional development, CRF derived from spectral impedance measurements may permit point-of-care diagnosis guiding surgical resection.