bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of multidrug resistant organism acquisition in an adult specialist burns service: a retrospective review
Authors: Cleland Heather , Tracy Lincoln M. , Padiglione Alex , Stewardson Andrew J. 
Published: June 2022

AbstractBackgroundMultidrug resistant organisms (MDROs) occur more commonly in burns patients than in other hospital patients and are an increasingly frequent cause of burn-related mortality. We examined the incidence, trends and risk factors for MDRO acquisition in a specialist burns service housed in an open general surgical ward, and general intensive care unit.MethodsWe performed a retrospective study of adult patients admitted with an acute burn injury to our specialist statewide tertiary burns service between July 2014 and October 2020. We linked patient demographics, injury, treatment, and outcome details from our prospective burns service registry to microbiology and antimicrobial prescribing data. The outcome of interest was first MDRO detection, stratified into the following groups of interest: methicillin-resistantStaphylococcus aureus(MRSA), vancomycin-resistant Enterococcus (VRE), two groups ofPseudomonas(carbapenem resistant, and piperacillin-tazobactam or cefepime resistant), carbapenem-resistantAcinetobacterspecies,Stenotrophomonas maltophilia, carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-PE). We used a Cox proportional hazards model to evaluate the association between antibiotic exposure and MDRO acquisition.ResultsThere were 2,036 acute admissions, of which 230 (11.3%) had at least one MDRO isolated from clinical specimens, most frequently wound swabs. While acquisition rates of individual MDRO groups varied over the study period, acquisition rate of any MDRO was reasonably stable over time. Carbapenem-resistantPseudomonaswas acquired at the highest rate over the study period (3.5/1000 patient days). The 12.8% (29/226) of MDROs isolated within 48 h were predominantly MRSA andStenotrophomonas.Median (IQR) time from admission to MDRO detection was 10.9 (5.6–20.5) days, ranging from 9.8 (2.7–24.2) for MRSA to 23.6 (15.7–36.0) for carbapenem-resistantP. aeruginosa. Patients with MDROs were older, had more extensive burns, longer length of stay, and were more likely to have operative burn management. We were unable to detect a relationship between antibiotic exposure and emergence of MDROs.ConclusionsMDROs are a common and consistent presence in our burns unit. The pattern of acquisition suggests various causes, including introduction from the community and nosocomial spread. More regular surveillance of incidence and targeted interventions may decrease their prevalence, and limit the development of invasive infection.
Reviewing the effects of deploying building information modelling (BIM) on the adoption of sustainable design in Gulf countries: a case study in Saudi Arabia
Authors: Alghamdi Mushref S. , Beach Thomas H. , Rezgui Yacine 
Published: June 2022

AbstractSustainable construction is a challenging prospect in Gulf countries such as Saudi Arabia and the use of Building Information Modelling (BIM) is often suggested as a solution. However, achieving improvement is associated with considerable challenges, particularly regarding energy efficiency improvements. Furthermore, the extreme environmental conditions in Saudi Arabia increase the demand for energy. As energy consumption in buildings is one of the main problems related to the built environment in both dry and hot climates, although in hot climates especially the issue is exacerbated by the particularly great need for cooling systems in buildings. On the other hand, one of the most important factors that affect Saudi Arabia’s building design is gender and function, demonstrating how the culture of Saudi Arabia, significantly influenced by the Islamic religion, affects design. This paper aims to present a literature review of the area of sustainable building design and the impact of cultural issues, focusing on the case of Saudi Arabia. This paper has analysed related literature in the area of sustainable building design and the influence of cultural issues, focusing on the case of Saudi Arabia. This review has identified the lack of using technology to support designs in Saudi Arabia, lack of achieving sustainability in Saudi Arabia, culture issues effect on designing in Saudi Arabia, and lack of using Building Information Modelling (BIM) in Saudi Arabia for both public and private project. These issues have led to a series of recommendations that have the potential to improve the adoption of sustainable design in Saudi Arabia by using (BIM). Some of these recommendations are developing and understanding the influence of cultural issues on achieving sustainable design. Secondly, analysing the different viewpoints on sustainability between the experts and members of the public. Furthermore, developing a framework of measures of sustainable design for buildings with consideration of specific factors. Additionally, showing the current level of using BIM technologies. Finally, developing a methodology, supported by BIM, for both government and private projects.
From pomiculture waste to biotechnological raw material: efficient transformation using ligninosomes and cellulosomes from Pleurotus spp.
Authors: Ćilerdžić Jasmina , Galić Milica , Stajić Mirjana 
Published: June 2022

AbstractThe goal of this study was to determine the capacity of Pleurotus spp. lignocellulosome to transform frequent pomiculture residues (grapevine-, plum-, and raspberry sawdust) into raw materials for biotechnological processes. All three lignocellulosics induced the synthesis of ligninolytic and cellulolytic enzymes in the tested species. Laccase was dominant in the ligninolytic cocktail, with a maximum activity of 40,494.88 U L−1 observed after the cultivation of P. pulmonarius on grapevine sawdust. Grapevine sawdust also proved to be the optimal substrate for the synthesis of versatile peroxidases especially in P. eryngii (1010.10 U L−1), while raspberry sawdust favored the production of Mn-dependent peroxidase in P. pulmonarius (479.17 U L−1). P. pulmonarius was the dominant cellulolytic agent and raspberry sawdust was optimal for the synthesis of xylanases, and endo- and exo-cellulases (15,746.35 U L−1, 9741.56 U L−1, and 836.62 U L−1), while grapevine sawdust mostly induced β-glucosidase activity (166.11 U L−1). The degree of residues delignification was more substrate- than species-dependent, ranging between 6.44 and 23.72% after the fermentation of grapevine and raspberry sawdust with P. pulmonarius. On the other hand, the lowest level of cellulose consumption was also observed on raspberry sawdust after the cultivation of P. eryngii, which together with high delignification also induced the highest selectivity index (1.27). The obtained results show the exceptional lignocellulolytic potential of Pleurotus spp. enzyme cocktails which opens up many possibilities for their application in numerous biotechnological processes.
Graphical Abstract
NEMA characterization of the SAFIR prototype PET insert
Authors: Khateri Parisa , Lustermann Werner , Ritzer Christian , Tsoumpas Charalampos , Dissertori Günther 
Published: June 2022

AbstractBackgroundThe SAFIR prototype insert is a preclinical Positron Emission Tomography (PET) scanner built to acquire dynamic images simultaneously with a 7 T Bruker Magnetic Resonance Imaging (MRI) scanner. The insert is designed to perform with an excellent coincidence resolving time of 194 ps Full Width Half Maximum (FWHM) and an energy resolution of 13.8% FWHM. These properties enable it to acquire precise quantitative images at activities as high as 500 MBq suitable for studying fast biological processes within short time frames (< 5 s). In this study, the performance of the SAFIR prototype insert is evaluated according to the NEMA NU 4-2008 standard while the insert is inside the MRI without acquiring MRI data.ResultsApplying an energy window of 391–601 keV and a coincidence time window of 500 ps the following results are achieved. The average spatial resolution at 5 mm radial offset is 2.6 mm FWHM when using the Filtered Backprojection 3D Reprojection (FBP3DRP) reconstruction method, improving to 1.2 mm when using the Maximum Likelihood Expectation Maximization (MLEM) method. The peak sensitivity at the center of the scanner is 1.06%. The Noise Equivalent count Rate (NECR) is 799 kcps at the highest measured activity of 537 MBq for the mouse phantom and 121 kcps at the highest measured activity of 624 MBq for the rat phantom. The NECR peak is not yet reached for any of the measurements. The scatter fractions are 10.9% and 17.8% for the mouse and rat phantoms, respectively. The uniform region of the image quality phantom has a 3.0% STD, with a 4.6% deviation from the expected number of counts per voxel. The spill-over ratios for the water and air chambers are 0.18 and 0.17, respectively.ConclusionsThe results satisfy all the requirements initially considered for the insert, proving that the SAFIR prototype insert can obtain dynamic images of small rodents at high activities ($$\sim$$∼500 MBq) with a high sensitivity and an excellent count-rate performance.
A d-axis based current differential protection scheme for an active distribution network
Authors: Zang Lindong , Zou Guibin , Zhou Chenghan , Zheng Maoran , Du Tao 
Published: June 2022

AbstractThe emergence of distributed generators has changed the operational mode and fault characteristics of the distribution network, in a way which can severely influence protection. This paper proposes a d-axis-based current differential protection scheme. The d-axis current characteristics of inverter-interfaced distributed generators and synchronous generators are analyzed. The differential protection criterion using sampling values of the d-axis current component is then constructed. Compared to conventional phase-based current differential protection, the proposed protection reduces the number of required communication channels, and is suitable for distribution networks with inverter-interfaced distributed generators with complex fault characteristics. Finally, a 10 kV active distribution network model is built in the PSCAD platform and protection prototypes are developed in RTDS. Superior sensitivity and fast speed are verified by simulation and RTDS-based tests.
Inclusion of information technology-based assessments of health-related quality of life in routine oncology practice in Uruguay
Authors: Castillo Cecilia , Alfonso Ana Laura , Dapueto Juan J. , Camejo Natalia , Silva Martín 
Published: June 2022

Abstract
Background
Previous research has shown that the inclusion of patient-reported outcomes measures in the patient’s visit to the oncologists might improve the quality of global health care. The aim of the study was to assess the feasibility, acceptance, and utility perceived by patients and oncologists of health-related quality of life (HRQL) assessments obtained prior to clinical visits, and to evaluate if this has an impact on patient’s well-being in a sample of Spanish-speaking patients from Uruguay.

Methods
Patients assisted regularly in the Oncology Clinic were randomized into two groups: an intervention group that completed a set of questionnaires (European Organisation for Research and Treatment of Cancer-Quality of Life Questionnaire-C30 (EORTC QLQ-C30) and Hospital Anxiety and Depression Scale using a touch screen device and a control group that did not respond to these questionnaires. At 2 months, the responses of all the participants to the Functional Assessment of Cancer Therapy-General (FACT-G) were collected over a telephone to determine whether there were differences in the HRQL between the intervention and control groups. The graphed scores of the intervention group were included in the clinical history of the patient during consultation. Patients and physicians completed the questionnaires on the usefulness of these measurements.

Results
In total, 58 patients participated in this study: 36 in the intervention group and 22 in the control group; 65% of the participants were female, and median age was 59 years (18–79). Regarding patients, 97% found the questionnaires easy to complete and thought that they included important questions. As for oncologists, 68.8% used the information and 87.5% found it useful for the consultation. There were no significant differences in the FACT-G scores between the intervention and control groups.

Conclusions
The routine HRQL assessments using an electronic device prior to the consultations were positively valued by almost all patients and physicians. This could significantly contribute to a better understanding of the patient's overall problems during consultation. These results confirm the benefits of integrating the patient’s self-reported quality of life outcomes into consultations.
Mental health impact on healthcare workers due to the COVID-19 pandemic: a U.S. cross-sectional survey study
Authors: Biber Joshua , Ranes Bethany , Lawrence Shanieek , Malpani Vishal , Trinh Trong Tony , Cyders Andrew , English Steven , Staub Charles L. , McCausland Kristen L. , Kosinski Mark , Baranwal Nishtha , Berg Daniel , Pop Rodica 
Published: June 2022

Abstract
Background
The COVID-19 pandemic has impacted the mental health and well-being of health care workers (HCWs). This study examined mental health outcomes and COVID-related stress impacts among a diverse sample of ambulatory HCWs, including clinicians and support staff, as well as the associations between mental health outcomes and work impairments in this population. Detailing these results can help in designing interventions to alleviate this burden.

Methods
“The Health Care Worker Stress Survey” was administered to ambulatory care providers and support staff at three multispecialty care delivery organizations as part of an online, cross-sectional study conducted between June 8, 2020, and July 13, 2020.

Results
The greatest stress impact reported by HCWs was the uncertainty regarding when the COVID-19 outbreak would be under control, while the least reported concern was about self-dying from COVID-19. Differences in COVID-19 stress impacts were observed by age, gender, and occupational risk factors. Approximately 50% of participants reported more than a minimal level of anxiety, including 22.5% who indicated moderate to severe levels of anxiety. Higher levels of anxiety were observed with younger ages and female gender, while occupational roles with increased exposure risk did not report higher levels of anxiety. Roughly two-thirds of the sample reported less than good sleep quality and one-third to one-half of the sample reported other sleep related problems that differed by age and gender. Role limitations due to emotional health correlated with COVID-19 related stress, anxiety and sleep problems.

Conclusions
Using established, validated measures, we quantified mental health outcomes within a diverse sample of ambulatory care HCWs during the pandemic. Younger and female HCWs reported greater anxiety burden; HCWs with higher occupational risk of COVID exposure did not report higher levels of anxiety. Notable proportions of HCWs reported sleep and work impairments. Due to the cross-sectional nature of the study, it is difficult to attribute these patterns to the pandemic. These results underscore the depth and extent of mental health outcomes in HCWs in ambulatory settings and raise important questions on new interventions to relieve that burden. Further research is needed to study specific interventions to support the mental health and wellbeing of HCWs.
Comparative performance of the EuroQol EQ-5D-5L and the CDC healthy days measures in assessing population health
Authors: Derkach Maryna , Al Sayah Fatima , Ohinmaa Arto , Svenson Lawrence W. , Johnson Jeffrey A. 
Published: June 2022

Abstract
Objectives
To examine the comparative performance of EuroQol EQ-5D-5L and Center for Disease Control Healthy Days measures in assessing population health.

Methods
Using data from 2014 Alberta Community Health Survey, a cross-sectional population-based survey (N = 7559), conducted in Alberta, Canada, we examined construct validity of the measures as indicators of population health. Differences in EQ-5D-5L index score, visual analogue scale (EQ-VAS), and CDC unhealthy days index across socio-demographic subgroups were tested by Mann–Whitney and Kruskal–Wallis tests using known-groups approach.

Results
EQ-5D-5L and CDC Healthy Days provided comparable assessments of population health in this sample. Both measures discriminated between subgroups defined by self-perceived health status, level of education, and material deprivation. The discriminative ability of CDC Healthy Days was limited in capturing variability in health among age groups compared to the EQ-5D-5L. Among participants who reported 0 unhealthy days, the proportion of those with level 3 problems in pain/discomfort varied from 1.1% for participants aged 18–24 to 19.2% for those over 75 years.

Conclusions
EQ-5D-5L demonstrated better construct validity than CDC Healthy Days in assessing health in a population-based sample of adults.
Healthcare provider and medical cannabis patient communication regarding referral and medication substitution: the Canadian context
Authors: Holman Alexis , Kruger Daniel J. , Lucas Philippe , Ong Kaye , Bergmans Rachel S. , Boehnke Kevin F. 
Published: June 2022

Abstract
Background
Patients use medical cannabis for a wide array of illnesses and symptoms, and many substitute cannabis for pharmaceuticals. This substitution often occurs without physician oversight, raising patient safety concerns. We aimed to characterize substitution and doctor-patient communication patterns in Canada, where there is a mature market and national regulatory system for medical cannabis.

Methods
We conducted an anonymous, cross-sectional online survey in May 2021 for seven days with adult Canadian federally-authorized medical cannabis patients (N = 2697) registered with two global cannabis companies to evaluate patient perceptions of Primary Care Provider (PCP) knowledge of medical cannabis and communication regarding medical cannabis with PCPs, including PCP authorization of licensure and substitution of cannabis for other medications.

Results
Most participants (62.7%, n = 1390) obtained medical cannabis authorization from their PCP. Of those who spoke with their PCP about medical cannabis (82.2%, n = 2217), 38.6% (n = 857) reported that their PCP had “very good” or “excellent” knowledge of medical cannabis and, on average, were moderately confident in their PCP’s ability to integrate medical cannabis into treatment. Participants generally reported higher ratings for secondary care providers, with 82.8% (n = 808) of participants rating their secondary care provider’s knowledge about medical cannabis as “very good” or “excellent.” Overall, 47.1% (n = 1269) of participants reported substituting cannabis for pharmaceuticals or other substances (e.g., alcohol, tobacco/nicotine). Of these, 31.3% (n = 397) reported a delay in informing their PCP of up to 6 months or more, and 34.8% (n = 441) reported that their PCP was still not aware of their substitution. Older, female participants had higher odds of disclosing cannabis substitution to their PCPs.

Conclusion
Most of the surveyed Canadian medical cannabis patients considered their PCPs knowledgeable about cannabis and were confident in their PCPs’ ability to integrate cannabis into treatment plans. However, many surveyed patients substituted cannabis for other medications without consulting their PCPs. These results suggest a lack of integration between mainstream healthcare and medical cannabis that may be improved through physician education and clinical experience.
Antiplatelets or anticoagulants? Secondary prevention in cervical artery dissection: an updated meta-analysis
Authors: The Ei Zune , Lin Ne Naing , Chan Ching Jocelyn , Loon Jason Cher Wei , Tan Benjamin Yong-Qiang , Seet Chee Seong Raymond , Teoh Hock Luen , Vijayan Joy , Yeo Leong Litt Leonard 
Published: June 2022

AbstractBackgroundExtracranial artery dissection involving either internal carotid artery or vertebral artery is a major cause of stroke in adults under 50 years of age. There is no conclusive evidence whether antiplatelets or anticoagulants are better suited in the treatment of extracranial artery dissection.ObjectivesTo determine whether antiplatelets or anticoagulants have advantage over the other in the treatment of extracranial artery dissection for secondary prevention of recurrent ischemic events or death.MethodsPresent meta-analysis followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement. Database search was done in Medline, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov from inception to May 2021 using pre-defined search strategy. Additional studies were identified from reference lists from included studies, reviews and previous meta-analyses. Outcome measures were ischaemic stroke, ischaemic stroke or transient ischaemic attack (TIA), and death.ResultsTwo RCTs and 64 observational studies were included in the meta-analysis. While the outcome measures of stroke, stroke or TIA and death were numerically higher with antiplatelet use, there were no statistically significant differences between antiplatelets and anticoagulants.ConclusionWe found no significant difference between antiplatelet and anticoagulation treatment after extracranial artery dissection. The choice of treatment should be tailored to individual cases.
St. Jude Total Therapy studies from I to XVII for childhood acute lymphoblastic leukemia: a brief review
Authors: Omar Abdallah A. , Basiouny Lina , Elnoby Ahmed S. , Zaki Abeer , Abouzid Mohamed 
Published: June 2022

AbstractThe therapy design of childhood acute lymphoblastic leukemia (ALL) has evolved over the past 60 years. The St. Jude Children’s Research Hospital has developed 17 treatment protocols from 1962 to 2017, aiming to have the most effective and least toxic treatment form. This review summarizes each protocol’s objectives, inclusion criteria, treatment phases, pharmacological agents, irradiation therapy, response criteria, risk stratification, type of relapse, and overall survival. The enhancement and successful application of preventive therapy for ALL and following a risk-stratified approach have progressively improved the cure rate of childhood ALL, with relatively few adverse sequelae. Moreover, St. Jude’s scientific theme serves as a reminder of the principal factor of research directed to a catastrophic disease such as ALL.