bluuebunny/crossref_metadata_2025_split huggingface dataset:
Young people don’t tend to ask for help more than once: Child and adolescent psychiatrists’ views on ailing mental health services for young New Zealanders
Authors: Every-Palmer Susanna , Grant Marion L , Thabrew Hiran 
Published: August 2022

Objectives To explore the views of New Zealand doctors working in child and adolescent psychiatry regarding the state of public mental health services. Methods All practicing child and adolescent psychiatrists/advanced trainees were electronically surveyed in August 2021. Quantitative and qualitative analysis of feedback was undertaken. Results Almost 100 specialists responded, an 80% response rate. High levels of dissatisfaction with current services and future service plans were identified. Content analysis identified an overarching theme that child and adolescent services were under great pressure, with subthemes of increased demand, a stretched workforce and social issues driving complex presentations. Recommendations were made for addressing workforce, service design and wider issues. Conclusions Multiple measures are needed to improve currently ailing child mental health services, including urgently expanding the number of psychiatrists and other clinical staff.
Early Radiographic and Clinical Outcomes of a Novel, Fixed-Bearing Fourth-Generation Total Ankle Replacement System
Authors: Kim Jaeyoung , Rajan Lavan , Bitar Rogerio , Caolo Kristin , Fuller Robert , Henry Jensen , Deland Jonathan , Ellis Scott J. , Demetracopoulos Constantine 
Published: August 2022

Background: The Cadence Total Ankle System is a 2-component, fixed-bearing fourth-generation total ankle arthroplasty (TAA) system that was introduced for clinical use in 2016. The purpose of this study was to report non–inventor, non–industry funded survivorship, radiographic and clinical outcomes, and early complications following use of this implant at a minimum of 2 years. Methods: This single-center retrospective study included patients who underwent TAA by 2 surgeons with this novel fixed-bearing system between January 2017 and September 2018. Forty-eight patients were evaluated at an average of 33.6 months. Radiographic outcomes included preoperative and postoperative tibiotalar angle on anteroposterior radiographs of the ankle, sagittal tibial angle (STA) on lateral radiographs of the ankle, and periprosthetic lucency formation and location. Revision and reoperation data were collected, and patient-reported outcomes were assessed using Patient Reported Outcomes Measurement Information System (PROMIS). Subgroup analysis assessed associations between preoperative deformity, postoperative implant alignment, PROMIS scores, and periprosthetic lucency formation. Results: Survivorship of implant was 93.7%, with 3 revisions, 1 due to infection and 2 due to loosening of the implant (1 tibial and 1 talar component). Three patients had reoperations (6.3%): 2 for superficial infection and 1 for gutter debridement due to medial gutter impingement. Fifteen patients (35.8%) developed periprosthetic lucencies, all on the tibial side. PROMIS scores improved after surgery in all domains except Depression. Patients with significant postoperative periprosthetic lucency had worse postoperative PROMIS Physical function scores than patients without lucency ( P < .05). Conclusion: This study demonstrated excellent minimum 2-year clinical and radiographic outcomes and low revision and reoperation rates of this new fourth-generation TAA system. Future studies with longer follow-up, especially on patients with periprosthetic lucency, are necessary to investigate the long-term complications and understand the long-term functional and radiographic outcomes of this implant.
Consumer Insights into Changing Water Consumption Behavior: A Social Marketing Formative Study
Authors: Ibrahim Ali , Rundle-Thiele Sharyn , Almestarihi Ra’d 
Published: August 2022

Background and Situation Analysis The United Nations has announced serious global water crises at the beginning of the 21st century. In the United Arab Emirates (UAE), the problem of water shortage is more significant than in other parts of the world, due to lack of the natural freshwater resources and extremely harsh weather. All of this compounded with the highest individual water consumption in the world; the average consumption per capita is 500 L a day, around 82% above the global average. Focus of the Article The main objectives of this study were to gain insights about factors that might impact residents water consumption behavior and open more avenues for using social marketing to influence residents’ behaviors. Research question The research questions are: RQ1: What beliefs are held about the UAEs current water situation? RQ2: What are the current water consumption behaviors of UoS residents? RQ3: What would facilitate lower water consumption? Importance to the Social Marketing Field The importance of this study is to develop a model which may be employed to change individual water consumption behavior using social marketing principles Method A case study methodology was applied to collect data from the University of Sharjah for this study, using the focus groups method. A convenience sample of six focus groups with a total of 39 participants of students, faculty members, administrative staff, and other stakeholders formed the basis of the current study. Results This study revealed that the residents lacked accurate knowledge about the water situation inside the country. In addition, consumers showed mismatch between their religious beliefs and actual consumption behaviors. Recommendations for research/or practice More studies and research should take place in this field, especially in connection with personal behavior issues where individuals need encouragement and incentives to change underlying habits, such as over-consumption of water, obesity, and road accidents.
‘If you had taken the lead…’ – a qualitative study of patients with chronic conditions and their perspective in clinical encounters with medical students
Authors: Rieffestahl Anne Marie , Mogensen Hanne O. , Morcke Anne Mette , Risør Torsten 
Published: August 2022

Objectives To explore what patients with chronic conditions emphasize as important in the patient-medical student conversation, and how the patients’ experiences relate to trust. Methods Twenty-one video-recorded sessions of patients’ feedback in simulation-based communication courses for medical students were observed, transcribed, analyzed inductively and organized into three themes. Results In the patients’ feedback, three aspects were emphasized as important relating to trust: a) when the medical student relates medical information to the patient's lifeworld, b) when the student leads the patient throughout the conversation, and c) when the patient gets emotional support from the student. The patients felt that being met this way by the students grows trust and allows them to lean into the uncertainties they experience while still feeling safe. Discussion The patients emphasize three aspects of importance in conversations with the medical students that grow trust. We argue that these aspects cannot be found in the traditional authority-led practice but can be found in leadership, which imply empathy and willingness to learn from patients. We suggest that students should learn that to effectively communicate with patients infers such leadership. By doing so, medical students can walk alongside their patients to build a relationship and nurture trust.
A Machine Learning Approach to Predicting Higher COVID-19 Care Burden in the Primary Care Safety Net: Hispanic Patient Population Size a Key Factor
Authors: Goldstein Evan V. , Wilson Fernando A. 
Published: August 2022

Introduction The federal government legislated supplemental funding to support community health centers (CHCs) in response to the COVID-19 pandemic. Supplemental funding included standard base payments and adjustments for the number of total and uninsured patients served before the pandemic. However, not all CHCs share similar patient population characteristics and health risks. Objective To use machine learning to identify the most important factors for predicting whether CHCs had a high burden of patients diagnosed with COVID-19 during the first year of the pandemic. Methods Our analytic sample included data from 1342 CHCs across the 50 states and D.C. in 2020. We trained a random forest (RF) classifier model, incorporating 5-fold cross-validation to validate the RF model while optimizing the model's hyperparameters. Final performance metrics were calculated following the application of the model that had the best fit to the held-out test set. Results CHCs with a high burden of COVID-19 had an average of 65.3 patients diagnosed with COVID-19 per 1000 patients in 2020. Our RF model had 80.9% accuracy, 80.1% precision, 25.0% sensitivity, and 98.1% specificity. The percentage of Hispanic patients served in 2020 was the most important feature for predicting whether CHCs had high COVID-19 burden. Conclusions Findings from our RF model suggest patient population race and ethnicity characteristics were most important for predicting whether CHCs had a high burden of patients diagnosed with COVID-19 in 2020, though sensitivity was low. Enhanced support for CHCs serving large Hispanic patient populations may have an impact on addressing future COVID-19 waves.
Complication Rates Are Similar Between Patients Aged <50 and >50 Years in Calcaneus Fractures Treated With the Sinus Tarsi Approach
Authors: Reed Logan A. , Mihas Alexander , Andrews Nicholas A. , Agarwal Abhinav , Wall Kevin C. , Spitler Clay A. , Johnson Michael D. 
Published: August 2022

Background: The sinus tarsi (ST) approach for calcaneus fractures has gained popularity in recent years with an increased interest in shifting to less invasive approaches for calcaneal fracture fixation allowing for adequate fixation if complications do not arise. Although the ST approach has gained acceptance as standard for calcaneus fracture fixation, the literature surrounding early complications rates based on age differences for this specific approach and pathology is lacking. The objective of this study was to determine if rates of complications based on age varied for patients undergoing open reduction and internal fixation (ORIF) of closed calcaneus fractures using the ST approach. Methods: A retrospective review of patients undergoing ORIF for closed calcaneus fractures from 2012 to 2020 was performed. Inclusion criteria were based on an age greater than 18 years, surgical management of a closed calcaneus fracture using a ST approach, requirement of a preoperative computed tomographic scan, and a minimum of 180 days’ follow-up. Patients were divided into 2 groups: those aged <50 years and those aged >50 years. Results: A total of 196 fractures were included with 114 fractures in the <50-year age group and 82 fractures in the >50-year age group. Mean age was 34.2 and 59.7 years in the younger and older groups, respectively. The older group had similar rates of wound dehiscence (1.2% vs 4.4%, P = .204), superficial surgical site infection (1.2% vs 2.6%, P = .490), deep infection (9.8% vs 7.9%, P = .648), and nonunion (4.9% vs 3.5%, P = .633) compared with the younger group. Rates of 30-day readmission, unplanned reoperation, and symptomatic hardware were not significantly different. Postoperative Bohler and Gissane angles were not significantly different between both groups. Conclusion: Older patients with intraarticular calcaneus fractures treated via the ST approach maintain complication rates similar to those in younger individuals. Level of Evidence: Level III, retrospective study.
Initial Impact of the COVID-19 Pandemic on a US Orthopaedic Foot and Ankle Clinic
Authors: Mehta Nabil , Hur Edward S. , Michalski Joseph , Fitch Ashlyn A. , Sayari Arash J. , Bohl Daniel D. , Holmes George B. 
Published: August 2022

Background: In the United States, the COVID-19 pandemic led to a nationwide quarantine that forced individuals to adjust their daily activities, potentially impacting the burden of foot and ankle disease. The purpose of this study was to compare diagnoses made in an orthopaedic foot and ankle clinic during the shelter-in-place period of the COVID-19 pandemic to diagnoses made during the same months of the previous year. Methods: A retrospective review of new patients presenting to the clinics of 4 fellowship-trained orthopaedic foot and ankle surgeons in a major United States city was performed. Patients in the COVID-19 group presented between March 22 and July 1, 2020, during the peak of the quarantine for this city. Patients in the control group presented during the same period of 2019. Final diagnosis, chronicity of symptoms (acute: ≤1 month), and mechanism of disease were compared between groups. Results: A total of 1409 new patient visits were reviewed with 449 visits in the COVID-19 group and 960 visits in the control group. The COVID-19 group had a significantly higher proportion of ankle fractures (8.7% vs 5.4%, P = .020) and stress fractures (4.2% vs 2.2%, P = .031), but a smaller proportion of Achilles tendon ruptures (0.7% vs 2.5%, P = .019). The COVID-19 group had a higher proportion of acute injuries (35.4% vs 23.5%, P < .001). Conclusion: There was a shift in prevalence of pathology seen in the foot and ankle clinic during the COVID-19 pandemic, which may reflect the adoption of different activities during the quarantine period and reluctance to present for evaluation of non-urgent injuries. Level of Evidence: Level III, retrospective cohort study.
Managing genetic diversity in breeding programs of small populations: the case of French local chicken breeds
Authors: Restoux Gwendal , Rognon Xavier , Vieaud Agathe , Guemene Daniel , Petitjean Florence , Rouger Romuald , Brard-Fudulea Sophie , Lubac-Paye Sophie , Chiron Geoffrey , Tixier-Boichard Michèle 
Published: August 2022

Abstract
Background
On-going climate change will drastically modify agriculture in the future, with a need for more sustainable systems, in particular regarding animal production. In this context, genetic diversity is a key factor for adaptation to new conditions: local breeds likely harbor unique adaptive features and represent a key component of diversity to reach resilience. However, local breeds often suffer from small population sizes, which puts these valuable resources at risk of extinction. In chickens, population management programs were initiated a few decades ago in France, relying on a particular niche market that aims at promoting and protecting local breeds. We conducted a unique comprehensive study of 22 French local breeds, along with four commercial lines, to evaluate their genetic conservation status and the efficiency of the population management programs.

Results
Using a 57K single nucleotide polymorphism (SNP) chip, we demonstrated that both the between- and within-breed genetic diversity levels are high in the French local chicken populations. Diversity is mainly structured according to the breeds’ selection and history. Nevertheless, we observed a prominent sub-structuring of breeds according to farmers’ practices in terms of exchange, leading to more or less isolated flocks. By analysing demographic parameters and molecular information, we showed that consistent management programs are efficient in conserving genetic diversity, since breeds that integrated such programs earlier had older inbreeding.

Conclusions
Management programs of French local chicken breeds have maintained their genetic diversity at a good level. We recommend that future programs sample as many individuals as possible, with emphasis on both males and females from the start, and focus on a quick and strong increase of population size while conserving as many families as possible. We also stress the usefulness of molecular tools to monitor small populations for which pedigrees are not always available. Finally, the breed appears to be an appropriate operational unit for the conservation of genetic diversity, even for local breeds, for which varieties, if present, could also be taken into account.
Characterization and phylogenetic analysis of multiple C2 domain and transmembrane region proteins in maize
Authors: Zhao Yujun , Qin Qianqian , Chen Li , Long Yun , Song Nannan , Jiang Haiyang , Si Weina 
Published: August 2022

Abstract
Background
Multiple C2 domain and transmembrane region proteins (MCTPs) are evolutionarily conserved and important signaling molecules. However, the MCTP gene family has not been comprehensively analyzed in maize.

Results
In this study, 385 MCTP genes were identified in all surveyed 38 species. Moreover, gene duplication mode exploration showed that whole genome duplication (WGD) mainly contributed to the expansion of MCTP genes in angiosperms. Phylogeny reconstruction with all surveyed species by the maximum-likelihood (ML) method showed five clades of MCTPs, Clades I to V. Each clade of MCTPs had conservative structures and motifs. Focusing on maize, 17 MCTPs were identified, and a neighborjoining (NJ) phylogenetic tree with only ZmMCTPs was also constructed. As expected, 17 MCTPs showed similar phylogenetic relationships in the neighbor-joining (NJ) tree with those in the maximum-likelihood (ML) tree and could also be divided into five subclades. Moreover, ZmMCTP members in different clades showed specific gene structure, conserved motif, and domain structure compositions. Intriguingly, most ZmMCTP genes were intronless. Analyses of isoelectric points (pIs) and grand averages of hydropathicity (GRAVYs) indicated that the N-terminus was more dispersive than the C-terminus. Further tissue-specific expression analysis indicated that duplicated ZmMCTP pairs involved in whole genome duplication (WGD) had similar expression trends. Finally, ZmMCTPs were transcriptionally altered under diverse abiotic stresses and hormone treatments.

Conclusions
Our results contribute to deciphering the evolutionary history of MCTPs in maize and other plants, facilitating further functional analysis of these factors, and provide a basis for further clarification of the molecular mechanism of stress responses.
The effect of DC electric field on the elongation growth, proton extrusion and membrane potential of Zea mays L. coleoptile cells; a laboratory study
Authors: Karcz Waldemar , Burdach Zbigniew 
Published: August 2022

Abstract
Background
In this study, we investigated the effect of an electric field, with an intensity similar to that of the Earth’s field, on plant cells growth. The molecular mechanism underlying this effect remains unclear.

Results
It was found that the electric field, depending on the applied voltage, its duration and the polarization of the maize seedlings, stimulated or inhibited the growth of the seedling organs (root, mesocotyl and coleoptile). Moreover, it was also noticed that the gravitropic response of maize seedlings was inhibited at all voltages studied. Simultaneous measurements of growth and external medium pH show that auxin(IAA, indole-3-acetic acid)- and fusicoccin(FC)-induced elongation growth and proton extrusion of maize coleoptile segments were significantly inhibited at higher voltages. The ionic current flowing through the single coleoptile segment during voltage application was 1.7-fold lower in segments treated with cation channel blocker tetraethylammonium chloride (TEA-Cl) and 1.4-fold higher with IAA compared to the control. The electrophysiological experiments show that the electric field caused the depolarization of the membrane potential of parenchymal coleoptile cells, which was not reversible over 120 min.

Conclusion
It is suggested that a DC electric field inhibits the plasma membrane H+ pump activity and K+ uptake through voltage-dependent, inwardly rectifying ZMK1 channels (Zea mays K+ channel 1). The data presented here are discussed, taking into account the “acid growth hypothesis” of the auxin action and the mechanism of gravitropic response induction.
Chronotype, chrononutrition and glucose tolerance among prediabetic individuals: research protocol for a prospective longitudinal study Chrono-DM™
Authors: Chong Guey Yong , Kaur Satvinder , Talib Ruzita Abd , Loy See Ling , Tan Hui Yin , Harjit Singh Sarjit Singh , Abdullah Rosmiza Binti , Mahmud Hanisah Binti , Siah Woan Yie , Koo Hui Chin 
Published: August 2022

Abstract
Background
Chronotype and chrononutrition, both are emerging research interests in nutritional epidemiology. However, its association with glycemic control in the Asia population is less clear. A better understanding of how activity/eating time can influence glucose levels in Asian prediabetic individuals may improve strategies for blood glucose control in Asian countries. The present paper describes the research protocol which aims to determine the associations of chronotype and chrononutrition with glucose tolerance among Malaysian prediabetic individuals.

Methods
This is a prospective longitudinal study named Chrono-DM™, that targets to recruit 166 newly diagnosed prediabetic individuals from the community clinics in Malacca, Malaysia. Respondents will be followed-up for 6 months: (1) baseline (1st oral glucose tolerance test (OGTT)); (2) second visit (at 3rd month); and (3) third visit (2nd OGTT at 6th month). Data collection includes sociodemographic and anthropometry measurements (weight, height, body fat, visceral fat, waist and hip circumference). Dietary intake and meal timing are collected using the 3-day dietary record while data on sleep pattern, light exposure, chronotype and chrononutrition will be collected using validated questionnaires. Physical activity will be recorded using a validated IPAQ questionnaire and pedometer during periods of using continuous glucose monitoring (CGM) sensor. CGM, fasting blood sugar (FBS), OGTT and HbA1c are performed to assess glycemic outcomes.

Discussion
The Chrono-DM™ study represents a novel approach to determining the association of chronotype and chrononutrition with glycemic control. We anticipate that this study will not only review the association of chronotype with glycemia measure but also provide greater insight into optimal meal time for glycemic control among prediabetic individuals in the Asian population.

Trial registration
NCT05163964 (Clinicaltrial.gov). Trial registration date: 20 December 2021.
Psychological coherence, inclusive leadership and implicit absenteeism in obstetrics and gynecology nurses: a multi-site survey
Authors: Jin Yu , Bi Qingquan , Song Guiqi , Wu Jun , Ding Hui 
Published: August 2022

AbstractBackgroundImplicit absenteeism is very common among clinical nurses. We aimed to evaluate the role of psychological coherence in the inclusive leadership and implicit absenteeism among obstetrics and gynecology nurses, to provide evidence to the clinical management of nurses.MethodsThrough the convenience sampling method, a survey of gynecology nurses in tertiary hospitals in 16 cities of Anhui Province, China was conducted using the General Information Questionnaire, the Stanford Implicit Absence Scale, the Inclusive Leadership Scale and the Sense of Coherence Scale. Statistical analysis was performed by SPSS 20.ResultsA total of 1080 nurses were included with an effective response rate of 93.5%. The average score of nurses' recessive absenteeism in this study was (16.8 ± 0.15). The average of inclusive leadership score was (34.25 ± 7.23). The average score of psychological coherence score of obstetrics and gynecology nurses was (55.79 ± 8.28). Pearson correlation analysis showed that there was a relationship between implicit absenteeism behavior, inclusive leadership, and the level of psychological coherence in obstetrics and gynecology nurses (allP < 0.05). Linear regression analysis indicated that psychological coherence played a partial mediating role between inclusive leadership and obstetrics and gynecology nurses' implicit absenteeism (allP < 0.05).ConclusionsObstetrics and gynecology nurses have serious recessive absenteeism with low sense of psychological coherence and inclusive leadership. Nursing managers should improve the psychological coherence through effective interventions, thereby reducing the incidence of implicit absenteeism.