bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open innovation: the key to advancing brain health
Authors: Eyre Harris A. , Searfoss Jason , Hopwood Malcolm , Berk Michael , Chen Shuo , Cummings Jeffrey , Veron Francois , Zikopoulou Vicki , Ibanez Agustin , Kelly Kacie , Soares Jair C. , Smith Erin , Gilbert Barnabas J. 
Published: July 2022

AbstractWith the exponential growth in investment attention to brain health—solutions spanning brain wellness to mental health to neurological disorders—tech giants, payers, and biotechnology companies have been making forays into this field to identify technology solutions and pharmaceutical amplifiers. So far, their investments have had mixed results. The concept of open innovation (OI) was first coined by Henry Chesbrough to describe the paradigm by which enterprises allow free flow of ideas, products, and services from the outside to the inside and vice versa in order to remain competitive, particularly in rapidly evolving fields where there is abundant, relevant knowledge outside the traditional walls of the enterprise. In this article, we advocate for further exploration and advancement of OI in brain health.
Plasma optics improving plasma accelerators
Authors: Döpp Andreas 
Published: July 2022

AbstractPlasma accelerators driven by high-power lasers can provide high-energy electron beams on a dramatically smaller scale than conventional radio-frequency accelerators. However, the performance of these accelerators is fundamentally limited by the diffraction of the laser. Laser-generated plasma waveguides can mitigate this problem and, combined with a controlled injection method for electrons, highlight the potential of novel laser-plasma optics.
Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients
Authors: Zhao Liuyang , Zhang Xiang , Zhou Yunfei , Fu Kaili , Lau Harry Cheuk-Hay , Chun Tommy Wai-Yiu , Cheung Alvin Ho-Kwan , Coker Olabisi Oluwabukola , Wei Hong , Wu William Ka-Kei , Wong Sunny Hei , Sung Joseph Jao-Yiu , To Ka Fai , Yu Jun 
Published: July 2022

AbstractLarge-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role and clinical significance of P. micra in colorectal tumorigenesis. The abundance of P. micra was examined in 309 fecal samples and 165 colon biopsy tissues of CRC patients and healthy subjects. P. micra was significantly enriched in fecal samples from 128 CRC patients compared to 181 healthy subjects (P < 0.0001); and in colon tissue biopsies from 52 CRC patients compared to 61 healthy subjects (P < 0.0001). Multivariate analysis showed that P. micra is an independent risk factor of poor survival in CRC patients (Hazard Ratio: 1.93). P. micra strain was isolated from feces of a CRC patient. Apcmin/+ mice gavaged with P. micra showed significantly higher tumor burden and tumor load (both P < 0.01). Consistently, gavage of P. micra significantly promoted colonocyte proliferation in conventional mice, which was further confirmed by germ-free mice. P. micra colonization up-regulated genes involved in cell proliferation, stemness, angiogenesis and invasiveness/metastasis; and enhanced Th17 cells infiltration and expression of Th17 cells-secreted cytokines (Il-17, Il-22, and Il-23) in the colon of Apcmin/+, conventional and germ-free mice. P. micra-conditioned medium significantly promoted the differentiation of CD4+ T cells to Th17 cells (IL-17+CD4+ phenotype) and enhanced the oncogenic Wnt signaling pathway. In conclusion, P. micra promoted colorectal tumorigenesis in mice by inducing colonocyte proliferation and altering Th17 immune response. P. micra may act as a prognostic biomarker for poor survival of CRC patients.
Cytotoxic evaluation and chemical investigation of tomatoes from plants (Solanum lycopersicum L.) grown in uncontaminated and experimentally contaminated soils
Authors: Russo Chiara , Barone Daniela , Lavorgna Margherita , Piscitelli Concetta , Macaluso Marcella , Pacifico Severina , Piccolella Simona , Giordano Antonio , Isidori Marina 
Published: July 2022

AbstractThe aim of this study was to evaluate the cytotoxic activity and the chemical composition of the tomato extracts coming from, Pomodoro Giallo and San Marzano Cirio 3, and then to evaluate the potential changes when plants were grown in soils contaminated by cadmium, chromium and lead. Extracts were investigated by UHPLC-HRMS and UV–Vis. Cell viability (CellTiter-Glo Luminescent assay), enzyme aldehyde dehydrogenase activity (ALDEFLOUR Assay), cell cycle progression (Accuri C6 Flow Cytometer), apoptosis and necrosis (Annexin V-FITC assay) were evaluated on two gastric cancer (AGS and NCI-N87) and two colorectal cancer (HT-29 and HCT 116) cell lines. Different content of polyphenol and carotenoid constituents was observed. Extracts from uncontaminated soil induced cytotoxic activity towards all selected cancer cells, while extracts coming from contaminated soils showed the aberrant phenotype increased in colorectal cancer cells. Chloroform extracts exerted the highest cytotoxic activity. AGS and HT-29 were the most sensitive to cell cycle arrest and to apoptosis. No necrotic effect was observed in HCT 116. The contrasting effects on cancer cells were observed based on tomato variety, the extract polarity, heavy metal identity, and tested cell line. The investigation of potential adverse health effects due to Cd in the fruits should be explored.
Findlater jet induced summer monsoon memory in the Arabian Sea
Authors: Kushwaha Vikas Kumar , Kumar S. Prasanna , Feba F , Ashok Karumuri 
Published: July 2022

AbstractA cross-equatorial low-level wind, known as Findlater Jet (FJ), modulates the thermocline in the Arabian Sea (AS) during summer monsoon (June to September). By analysing ocean and atmospheric data, we show that the FJ signal gets ‘trapped’ in the AS in the form of upper ocean heat content till the following winter months (December to February). This memory is the consequence of the combined effect of FJ-induced wind stress curl and the annual downwelling Rossby waves in the AS. During the summer monsoon months, the strong low-level westerly winds cause a negative wind stress curl in the south of the FJ axis over the central AS, resulting in a deep thermocline and high magnitude of heat being trapped. In winter monsoon months, though the wind stress curl is positive over large parts of the AS and could potentially shoal the thermocline and reduce the upper ocean heat content in the central AS, this does not happen due to two reasons. Firstly, winds are weaker, and spread over a larger area over the AS making the magnitude of the wind stress curl low. Secondly, westward propagating downwelling Rossby wave radiated from the eastern AS deepens the thermocline and prevents ventilation of the trapped heat. During the following spring, the collapse of the Rossby waves leads to the shoaling and mixing of underlying waters with surface waters thereby resurfacing of the trapped heat. The resurfacing of the trapped heat makes the AS a memory bank of the FJ induced signal.
Chlorophytes response to habitat complexity and human disturbance in the catchment of small and shallow aquatic systems
Authors: Celewicz Sofia , Kozak Anna , Kuczyńska-Kippen Natalia 
Published: July 2022

AbstractHuman-originated transformation in the catchment area may be reflected in the water quality and ecological state of the aquatic environment. Chlorophytes, the most common and diverse group of microalgae, may be a valuable tool for studies of small water bodies, ecosystems poorly recognized but extremely sensitive to the climate changes. Here we investigated the response of the chlorophytes to abiotic and biotic factors in different habitats and ponds’ catchments. Chlorophytes demonstrated a prevalence towards a specific type of catchment area. Field ponds supported chlorophytes typical for nutrient-rich/high-organic and shallow well-mixed waters. Forest ponds supported high chlorophyte diversity. A high importance of desmids, tolerant to light deficiency, confirms their preferences towards lower pH and lower trophic state in the forest ponds. Habitat type strongly impacted the distribution of chlorophytes. Great abundance and fertile-water species were associated with the open water, whereas aquatic plants hosted relatively low chlorophyte abundance which is a derivate of the filtrators grazing as well as the nutrient uptake and shadowing by macrophytes. Macrophyte-dominated zones created favorable conditions for some periphytic desmids and filamentous chlorophytes, species preferring lower trophic state and co-occurring with zooplankton. We assume that cosmopolitan chlorophytes can be adapted for determination of the ecological value of small water bodies, including the level of habitat heterogeneity. But chlorophytes clearly react to the level of human impact in the ponds’ catchment, both specific species and functional groups. Thus, we recommend them, particularly desmids, for water quality state assessment in ponds.
Organic amendment additions to cadmium-contaminated soils for phytostabilization of three bioenergy crops
Authors: Taeprayoon Puntaree , Homyog Kunaporn , Meeinkuirt Weeradej 
Published: July 2022

AbstractThe effects of organic amendments on the phytoremediation of cadmium (Cd) in acacia (Acacia mangium), jatropha (Jatropha curcas), and cassava (Manihot esculenta) were investigated. The bone meal/bat manure and leonardite/bat manure amendments resulted in better growth performance in both acacia and cassava (growth rate in dry biomass; GRDB 24.2 and 22.2, respectively), while bone meal (GRDB 17.2) was best for jatropha. The lower root/shoot ratio values of jatropha and acacia suggest that these species were better suited than cassava on Cd-contaminated soil. Cassava experienced toxicity symptoms after harvest (3 months). Acacia root accumulated somewhat greater Cd concentrations (up to 5.1 mg kg−1) than cassava and jatropha roots (2.2–3.9 and 2.7–4.1 mg kg−1, respectively). The bone meal and chicken manure (BMCM) treatment for jatropha had the highest bioconcentration factor for root (1.3) and the lowest translocation factor (0.7). Despite the fact that this treatment had substantial Cd concentrations in the soil (3.1 mg kg−1), low Cd accumulation value (3.2 mg kg−1) and the lowest Cd uptake value (127.8 mg plant−1) were observed, clearly indicating that this amendment reduced Cd bioavailability. When growth performance of the study plants is considered, jatropha and acacia may be suitable for phytomanagement of Cd-contaminated soil.
Socio-psychological determinants of Iranian rural households' adoption of water consumption curtailment behaviors
Authors: Savari Moslem , Mombeni Ameneh Savari , Izadi Hamed 
Published: July 2022

AbstractDealing with a growing population and a shortage of drinking water is a major challenge for politicians and planners. A key factor in ensuring a sustainable water supply is water conservation at the household level, which can increase productivity and save water resources. Therefore, promoting water consumption curtailment behavior will contribute significantly to reducing the global water crisis, especially in arid and semi-arid regions. Water consumption curtailment behaviors depend on individuals’ encouragement to choose and adopt voluntary behaviors and cannot be enforced by any political or planning power. In order to encourage water conservation those social and psychological factors should be considered that influence individuals to participate or adopt water consumption curtailment behaviors. Therefore, the study of factors influencing rural households' water consumption curtailment behaviors is of great importance. This study aimed to describe the socio-psychological factors influencing water consumption curtailment behaviors among rural households in southwestern Iran. The extended theory of planned behavior (ETPB) was used as a theoretical framework in this study along with descriptive norms (DN), moral norms (MN), habits, and justification. Data were collected using a questionnaire and analyzed using structural equation modeling (SEM). The results showed that ETPB can explain 35% and 54% of intention and water consumption curtailment behaviors among rural households in Iran. Our findings may assist policymakers in reducing domestic water consumption.
A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment
Authors: Cornelison R. C. , Yuan J. X. , Tate K. M. , Petrosky A. , Beeghly G. F. , Bloomfield M. , Schwager S. C. , Berr A. L. , Stine C. A. , Cimini D. , Bafakih F. F. , Mandell J. W. , Purow B. W. , Horton B. J. , Munson J. M. 
Published: July 2022

AbstractGlioblastoma is an aggressive brain cancer characterized by diffuse infiltration. Infiltrated glioma cells persist in the brain post-resection where they interact with glial cells and experience interstitial fluid flow. We use patient-derived glioma stem cells and human glial cells (i.e., astrocytes and microglia) to create a four-component 3D model of this environment informed by resected patient tumors. We examine metrics for invasion, proliferation, and putative stemness in the context of glial cells, fluid forces, and chemotherapies. While the responses are heterogeneous across seven patient-derived lines, interstitial flow significantly increases glioma cell proliferation and stemness while glial cells affect invasion and stemness, potentially related to CCL2 expression and differential activation. In a screen of six drugs, we find in vitro expression of putative stemness marker CD71, but not viability at drug IC50, to predict murine xenograft survival. We posit this patient-informed, infiltrative tumor model as a novel advance toward precision medicine in glioblastoma treatment.
Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development
Authors: Yang Jihong , Li Yangbai , Li Suying , Zhang Yan , Feng Ruizhi , Huang Rui , Chen Minjian , Qian Yun 
Published: July 2022

AbstractIn order to investigate the metabolic characteristics of human follicular fluid (FF) and to reveal potential metabolic predictors of follicular development (FD) with clinical implications, we analyzed a total of 452 samples based on a two-stage study design. In the first stage, FF samples from both large follicles (LFs) and matched-small follicles (SFs) of 26 participants were analyzed with wide-spectrum targeted metabolomics. The metabolic signatures were described by multi-omics integration technology including metabolomic data and transcriptomic data. In the second stage, the potential biomarkers of FD were verified using enzyme-linked immunoassay with FF and blood serum from an independent 200 participants. We describe the FF metabolic signatures from ovarian follicles of different developmental stages. Lysophosphatidylcholine (LPC) can be used as a biomarker of FD and ovarian sensitivity, advancing the knowledge of metabolic regulation during FD and offering potential detection and therapeutic targets for follicle and oocyte health improvements in humans.
SNGuess: A method for the selection of young extragalactic transients
Authors: Miranda N. , Freytag J. C. , Nordin J. , Biswas R. , Brinnel V. , Fremling C. , Kowalski M. , Mahabal A. , Reusch S. , van Santen J. 
Published: July 2022

Context.With a rapidly rising number of transients detected in astronomy, classification methods based on machine learning are increasingly being employed. Their goals are typically to obtain a definitive classification of transients, and for good performance they usually require the presence of a large set of observations. However, well-designed, targeted models can reach their classification goals with fewer computing resources.Aims.The aim of this study is to assist in the observational astronomy task of deciding whether a newly detected transient warrants follow-up observations.Methods.This paper presents SNGuess, a model designed to find young extragalactic nearby transients with high purity. SNGuess works with a set of features that can be efficiently calculated from astronomical alert data. Some of these features are static and associated with the alert metadata, while others must be calculated from the photometric observations contained in the alert. Most of the features are simple enough to be obtained or to be calculated already at the early stages in the lifetime of a transient after its detection. We calculate these features for a set of labeled public alert data obtained over a time span of 15 months from the Zwicky Transient Facility (ZTF). The core model of SNGuess consists of an ensemble of decision trees, which are trained via gradient boosting.Results.Approximately 88% of the candidates suggested by SNGuess from a set of alerts from ZTF spanning from April 2020 to August 2021 were found to be true relevant supernovae (SNe). For alerts with bright detections, this number ranges between 92% and 98%. Since April 2020, transients identified by SNGuess as potential young SNe in the ZTF alert stream are being published to the Transient Name Server (TNS) under the AMPEL_ZTF_NEW group identifier. SNGuess scores for any transient observed by ZTF can be accessed via a web servicehttps://ampel.zeuthen.desy.de/api/live/docs. The source code of SNGuess is publicly availablehttps://github.com/nmiranda/SNGuess.Conclusions.SNGuess is a lightweight, portable, and easily re-trainable model that can effectively suggest transients for follow-up. These properties make it a useful tool for optimizing follow-up observation strategies and for assisting humans in the process of selecting candidate transients.
A method for identifying metal-poor stars with Gaia BP/RP spectra
Authors: Xylakis-Dornbusch T. , Christlieb N. , Lind K. , Nordlander T. 
Published: July 2022

Context. The study of the oldest and most metal-poor stars in our Galaxy promotes our understanding of the Galactic chemical evolution and the beginning of Galaxy and star formation. However, they are notoriously difficult to find, with only seven stars at [Fe/H] < −5.0 having been detected to date. Thus, the spectrophotometric data of 219 million sources which became available in the third Gaia Data Release comprise a very promising dataset for the identification of metal-poor stars.
Aims. We want to use the low-resolution Gaia Blue Photometer/Red Photometer (BP/RP) spectra to identify metal-poor stars. Our primary aspiration is to help populate the poorly constrained tail of the metallicity distribution function of the stellar halo of the Galaxy.
Methods. We developed a metal-poor candidate selection method based on flux ratios from the BP/RP Gaia spectra, using simulated synthetic spectra.
Results. We found a relation between the relative iron abundance and the flux ratio of the Ca H & K region to that of the Hβ line. This relation is temperature and surface gravity dependent, and it holds for stars with 4800 K ≤ Teff ≤ 6300 K. We applied it to noisy simulated synthetic spectra and inferred [Fe/H] with an uncertainty of σ[Fe/H] ≲ 0.65 dex for −3 ≤ [Fe/H] ≤ 0.5 and G = 15–17 mag, which is sufficient to identify stars at [Fe/H] < −2.0 reliably. We predict that by selecting stars with inferred [Fe/H] ≤ −2.5 dex, we can retrieve 80% of the stars with [Fe/H] ≤ −3 and have a success rate of about 50%, that is one in two stars we select would have [Fe/H] ≤ −3. We do not take into account the effect of reddening, so our method should only be applied to stars which are located in regions of low extinction.
Secret et ravage : un nouage dans la douleur
Authors: Lorriot Simon 
Published: July 2022

L’article se propose d’étudier la fibromyalgie dans des perspectives psychanalytiques et psychopathologiques à partir d’une situation clinique. La fibromyalgie, où la douleur et l’épuisement constituent les principaux symptômes, reste souvent appréhendée par la médecine comme une énigme sans substrat organique bien identifié. Les ressorts inconscients de la plainte douloureuse sont ici à l’étude. Ce travail interroge dans un premier temps la douleur comme l’expression psychosomatique d’un secret de famille. Puis dans un second temps elle est envisagée comme le lieu d’inscription d’une énigme : celle de la féminité, à partir du concept de ravage.
Laser produced soft x-ray source diagnostics with temporal, spectral, and spatial resolution
Authors: Fraenkel M. , Ehrlich Y. , Rubin D. , Ferber Y. , Sturm G. 
Published: July 2022

We demonstrate the use of three diagnostic tools which simultaneously view the target from nearly the same direction, and their results are combined to provide temporally, spectrally, and spatially resolved absolutely calibrated target emission information. To demonstrate this capability, Au targets were irradiated by 1.8 kJ, 3 ns laser pulses to produce broadband soft x-ray emission in the 0.1–3.5 keV spectral range. Target diagnostics included a time-resolved x-ray diode array, each measured a partial spectral band, time-integrated spectrally resolved absolutely calibrated transmission grating spectrometer, and static and time-resolved soft x-ray imagers coupled to a charge-coupled device camera and to a streak camera, respectively, measuring spatially and temporally resolved radiation at the main Au target emission bands. The combined temporally, spectrally, and spatially resolved absolutely calibrated target emission result can be compared to simulations and be used to design and analyze experiments in which the source emission is used as a drive for various physical processes.
Naïve English-speaking learners’ use of indirect positive evidence
Authors: Li Ying , Goad Heather 
Published: July 2022

Abstract
When second language learners are faced with acquiring a grammar that is a subset of their native language
grammar, direct positive evidence is unavailable. We question whether learners can instead use indirect positive evidence:
evidence drawn from errors in the learner’s L1 made by native speakers of the learner’s L2. We examine if naïve English-speaking
learners of Mandarin can determine from plural omission errors in Mandarin speakers’ English productions that Mandarin marks
plural in a subset of conditions under which English does. Participants were exposed to indirect positive evidence via an
English-medium dialogue where a native Mandarin-speaking interlocutor produced all contextually plural nouns as singulars.
Subsequently, participants learnt 12 Mandarin-like nouns in singular contexts, after which their word learning was tested using
both singular and plural pictures as prompts. Forty percent of participants correctly deduced that strings to which they had
assigned singular interpretations were also appropriate in plural contexts. Follow-up questions revealed that they noticed the
errors in the dialogue and used these to inform their understanding of plural marking in Mandarin. This result suggests that
indirect positive evidence may be an effective tool for real language learners to acquire a grammar that is a subset of their
native grammar.
Review of scaling effects on physical properties and practicalities of cantilever sensors
Authors: Yang C-K , van der Drift E W J M , French P J 
Published: July 2022

Abstract
Reducing sensor dimension is a good way to increase system sensitivity and response. However the advantages gained must be weighed against other effects which also became significant during the scaling process. In this paper, the scaling effect of cantilever sensors from micrometre to nanometre regimes is reviewed. Changes in the physical properties such as Q-factor, Young’s modulus, noise and nonlinear deflections, as well as effects on practical sensor applications such as sensor response and sensor readouts, are presented. Since cantilever is an elemental transducer and device building block, its scaling effects can be further extrapolated to other sensing systems and applications.