bluuebunny/crossref_metadata_2025_split huggingface dataset:
Literacy (Dis)Orientations in a Secondary Classroom: Possibilities and Limits of an IntersectionalLGBTQ+‐Inclusive Curriculum
Authors: Schey Ryan 
Published: November 2022

AbstractDrawing from a yearlong literacy ethnography conducted at a high school in a Midwestern U.S. city, this article extends queer literacies and queer pedagogies scholarship by exploring the frictions and resonances between strategies of inclusion and queering. While inclusion strategies emphasize using expanded representations of sexuality and gender, such as of LGBTQ+ life, queering approaches often trouble inclusion through, for instance, questioning normativities and epistemologies and embracing partiality, uncertainty, and crisis in learning. To unpack interconnections between inclusion and queering, I present an ethnographic case of a lesson in a sophomore humanities course, focusing on the teacherly moves of an English language arts educator leading an instructional conversation about a nonfiction article describing intersections among sexuality, gender, race, ethnicity, and class with respect to food insecurity. Engaging Ahmed's (2006) queer theorization of orientations, I develop the heuristic ofliteracy (dis)orientationsto describe the layered mixture of classroom literacy performances challenging and reifying oppressive values regarding intersections among sexuality, gender, race, ethnicity, and class. The teacher disoriented students away from (homo)normativities regarding knowledge of LGBTQ+ communities and reoriented them toward and around nuanced, intersectional understandings of queer and trans life. However, these anti‐oppressive possibilities were limited by orientations around a banking model of education and binaries. This ethnographic case suggests that educators sanctioning literacy orientationstowardintersectional LGBTQ+‐inclusive curriculum presents possibilities for liberatory social change insofar as they disorient students away from education‐as‐banking and epistemological binaries and reorient themaroundalternative ways of knowing, specifically intersectionality as a queering epistemology.
Predicting nanomaterials pulmonary toxicity in animals by cell culture models: Achievements and perspectives
Authors: Di Ianni Emilio , Jacobsen Nicklas Raun , Vogel Ulla , Møller Peter 
Published: November 2022

AbstractAnimal experiments are highly relevant models for the assessment of toxicological effects of engineered nanomaterials (ENMs), due to lack of biomonitoring and epidemiological studies. However, the expanding number of ENMs with different physico‐chemical properties strains this approach, as there are ethical concerns and economical challenges with the use of animals in toxicology. There is an urgent need for cell culture models that predict the level of toxicological responses in vivo, consequently reducing or replacing the use of animals in nanotoxicology. However, there is still a limited number of studies on in vitro–in vivo correlation of toxicological responses following ENMs exposure. In this review, we collected studies that have compared in vitro and in vivo toxic effects caused by ENMs. We discuss the influence of cell culture models and exposure systems on the predictability of in vitro models to equivalent toxic effects in animal lungs after pulmonary exposure to ENMs. In addition, we discuss approaches to qualitatively or quantitatively compare the effects in vitro and in vivo. The magnitude of toxicological responses in cells that are exposed in submerged condition is not systematically different from the response in cells exposed in air–liquid interface systems, and there appears to be similar ENMs hazard ranking between the two exposure systems. Overall, we show that simple in vitro models with cells exposed to ENMs in submerged condition can be used to predict toxic effects in vivo, and identify future strategies to improve the associations between in vitro and in vivo ENMs‐induced pulmonary toxicity.This article is categorized under:
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Bismuth nanomaterials as contrast agents for radiography and computed tomography imaging and their quality/safety considerations
Authors: Yu Huan , Guo Haoxiang , Wang Yong , Wang Yangyun , Zhang Leshuai 
Published: November 2022

AbstractContrast agents for radiography and computed tomography (CT) scans are substances that can enhance the contrast of blood vessels and soft tissue with detailed imaging information of the diseased sites. However, the large doses, short circulation time and adverse effects are the intrinsic limitations of CT contrast agents, preventing their extended and safe use in the clinical setting. Bismuth nanoparticles (NPs) have gained attention for the high X‐ray absorption of bismuth elements with acceptable biocompatibility, showing their potential to be translated into commercialized CT contrast agents. Compared with traditional iodine contrast agents, bismuth NPs are characterized by prolonged circulation time and enhanced contrast, largely due to the surface modification and enhanced permeability and retention effect of NPs. Bismuth NPs can also be flexibly upgraded into sophisticated nanoagents for multimodal imaging and therapeutic purposes by complexation with supporting chemicals, small molecule drugs, fluorescence labels, and other functional agents. Additionally, the affinity and retention of the bismuth NPs in the diseased sites can be further improved by modification of the targeting moiety on the NPs surface. However, a simple synthetic process and low complexity of bismuth NPs are highly recommended for scaling out and quality control of nanoagents with commercialization potential. Since product safety is a prerequisite for the translation of bismuth NPs from bench to the clinic, we focus on recent advances in the distribution, elimination, and toxicity of bismuth NPs previously reported. Finally, we delineate the associated mechanisms for nephrotoxicity and the strategy to reduce the toxicity of bismuth NPs.This article is categorized under:
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
A 13-year patient journey of infant giant clival chordoma: case report and literature review
Authors: Apps J. , Gagen R. , Neumann E. , Solanki G. , English M. 
Published: November 2022

Abstract
Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case to present without skull base involvement and the fourth case of chordoma in a patient with tuberous sclerosis (TS) Kombogiorgas (Childs Nerv Syst 22(10):1369–1374, 2006). In this report, we provide an update on this patient’s journey through a range of therapeutic options and summarize an update of the literature, since 2006, for this patient group.
All-suture anchors for distal biceps tendon repair: a preliminary outcome study
Authors: Lappen Sebastian , Geyer Stephanie , Kadantsev Pavel , Hinz Maximilian , Kleim Benjamin , Degenhardt Hannes , Imhoff Andreas B. , Siebenlist Sebastian 
Published: November 2022

Abstract
Introduction
The aim of this study was to retrospectively evaluate the clinical outcome of double intramedullary all-suture anchors’ fixation for distal biceps tendon ruptures.

Materials and methods
A retrospective case series of patients who underwent primary distal biceps tendon repair with all-suture anchors was conducted. Functional outcome was assessed at a minimum follow-up of at 12 months based on the assessments of the Mayo Elbow Performance Score (MEPS), Andrews–Carson Score (ACS), Quick Disabilities of the Arm, Shoulder, and Hand questionnaire (QuickDASH), and the Visual Analog Scale (VAS) for pain. Maximum isometric strength test for flexion and supination as well as postoperative range of motion (ROM) were determined for both arms.

Results
23 patients treated with all-suture anchors were assessed at follow-up survey (mean age 56.5 ± 11.4 years, 96% male). The follow-up time was 20 months (range Q0.25–Q0.75, 15–23 months). The following outcome results were obtained: MEPS 100 (range Q0.25–Q0.75, 100–100); ACS 200 (range Q0.25–Q0.75, 195–200); QuickDASH 31 (range Q0.25–Q0.75, 30–31); VAS 0 (range Q0.25–Q0.75, 0–0). The mean strength compared to the uninjured side was 95.6% (range Q0.25–Q0.75, 80.9–104%) for flexion and 91.8 ± 11.6% for supination. There was no significant difference in ROM or strength compared to the uninjured side and no complications were observed in any patient.

Conclusion
Distal biceps tendon refixation using all-suture anchors provides good-to-excellent results in terms of patient-reported and functional outcome. This repair technique appears to be a viable surgical option, although further long-term results are needed.

Level of evidence
Level IV (case series)
Assessment of atlantoaxial rotation: how accurate is clinical measurement? a comparative study of cervical range of motion using MRI and standard orthopedic techniques
Authors: Mayer Michael , Koller Juliane , Auffarth Alexander , von Amelunxen Berndt , Ortmaier Reinhold , Hitzl Wolfgang , Koller Heiko 
Published: November 2022

Abstract
Purpose
Measurement of neck rotation is currently reliant on radiologic imaging. Given the radiation exposure for CT imaging and the additional inconvenience for the patients, an alternative assessment is needed. Goniometers are comfortably to use and easy to access, also for private consulting. The aim of this study was the assessment of whether a handheld goniometer can be used for accurately measuring the rotation of C1-C2.

Methods
Clinical measurement of rotation was taken in flexed position of the neck. As comparison functional MRI was used. The measured rotation of C1-C2 was compared to identify the accuracy of the goniometer, in comparison to functional MRI scan.

Results
Analysis of accuracy using a goniometer and dynamic MRI to assess C1-2 axial rotation showed significant differences for absolute values, but not regarding the percentage of rotation compared to total neck rotation.

Conclusion
The goniometer is exact to impartially determine the percentage contribution of C1-2 rotation to total neck rotation.
Unlike severe periodontitis, caries does not associate with intracranial aneurysms or aneurysmal subarachnoid hemorrhage
Authors: Hallikainen Joona , Pessi Tanja , Vehkalahti Miira , Suominen Anna Liisa , Pyysalo Mikko , Frösen Juhana 
Published: November 2022

Abstract
Purpose
Periodontal diseases and caries are common oral diseases that predispose to tooth loss if untreated. In this study, we investigated whether loss of teeth or caries associate with intracranial aneurysm (IA) pathology similar to periodontal diseases.

Methods
A total of 166 patients with either IA or aneurysmal subarachnoid hemorrhage (aSAH) underwent oral examination in Kuopio University Hospital and Tampere University Hospital. Findings were compared to geographically matched controls acquired from cross-sectional Health2000 survey. This study consisted of three sequential steps. First, we compared the number of missing teeth and prevalence of caries in IA and aSAH patients and geographically matched control population, second step was a multivariate analysis including other risk factors, and third step was a 13-year follow-up of the Health2000 survey participants with missing teeth or caries at baseline.

Results
Loss of teeth did not significantly differ between IA patients and controls. In logistic regression model adjusted for known risk factors and demographic data, 1–4 caries lesions (OR: 0.40 95%Cl 0.2–0.9, p = 0.031) was associated with lack of IAs, while age (OR: 1.03 95%Cl 1.01.1 p = 0.024), current smoking (OR: 2.7 95%Cl 1.4–5.1, p = 0.003), and severe periodontitis (OR: 5.99 95%Cl 2.6–13.8, p < 0.001) associated to IA formation. In the cox-regression, severe periodontitis at baseline increased the risk of aSAH (HR: 14.3, 95%Cl 1.5–135.9, p = 0.020) during a 13-year follow-up, while caries or missing teeth did not.

Conclusion
Unlike severe periodontitis, caries does not increase the risk of IAs and aSAHs. However, cariogenic bacteria may participate to IA pathology by disseminating to circulation via inflamed gingival tissue.
Posterolateral transpedicular approach for ventrally seated cervicothoracic spinal cord lesions: how I do it
Authors: Cristaldi P. M. F. , Parlangeli A. , Nicoli D. , Incerti M. 
Published: November 2022

Abstract

Background
Surgical exposure of lower cervical and upper thoracic intradural extramedullary lesions located along the ventral medulla are among the most complexes to address in spinal surgery, and their surgical removal carries a high risk.

Methods
We describe the surgical steps of a posterolateral transpedicular approach for resection of an intradural extramedullary lesion located anterolaterally at C7-T1 level.

Conclusions
A posterolateral transpedicular approach is a safe and efficient surgical corridor to explore the ventral spinal cord and to have a direct access to lower cervical-upper thoracic lesions without the extensive manipulation of the spinal cord and the spine instability.
Co-operative Learning in Undergraduate Mathematics and Science Education: A Scoping Review
Authors: Møgelvang Anja , Nyléhn Jorun 
Published: November 2022

AbstractTo cope with an unpredictable future, higher education in mathematics and science (MS) needs to educate a knowledgeable and skilled workforce. Co-operative learning (CL) is a teaching method associated with increased academic achievement and development of generic skills. Thus, the purposes of this scoping review are to assess the evidence base of CL in undergraduate MS education to inform teaching practices and to identify potential knowledge gaps to inform future research. The review covers 24 empirical studies conducted from 2010 to 2020 on the prevalence, uses, and outcomes of CL elements in undergraduate MS education. The results show that there are few such studies, and these are rarely conducted outside the US or in disciplines other than chemistry. The most frequently implemented CL elements in the included studies are heterogeneous group formation, the use of roles, and different CL structures. The most prevalent student outcome of implemented CL elements in the reviewed studies is enhanced academic success, followed by student attitudes, generic skills, and psychological health. The results have implications for future implementation of and research on CL in international MS higher education.
Novel high-performance QCA Fredkin gate and designing scalable QCA binary to gray and vice versa
Authors: Safaiezadeh Behrouz , Kettunen Lauri , Haghparast Majid 
Published: November 2022

AbstractIn the design of digital logic circuits, QCA technology is an excellent alternative to CMOS technology. Its advantages over CMOS include low power consumption, fast circuit switching, and nanoscale design. Circuits that convert data between different formats are code converters. Code converters have an essential role in high-performance computing and signal processing. In this paper, first, we proposed a novel QCA structure for the quantum reversible Fredkin gate. Second, we proposed 4-bit and 8-bit QCA binary-to-gray converter and vice versa. For the second proposal, both reversible and irreversible structures are suggested. The proposed structures are scalable up to N bits. To change the conversion type from B2G to G2B, we use a 2:1 QCA multiplexer. The proposed QCA Fredkin is applied in the reversible design of QCA code converters as multiplexers. The suggested designs are simulated using the QCADesigner tool. Then we calculated figures of merit, including cell counts, occupied areas, and clock zones. Finally, we compare the proposed structures to existing research. Our proposed approach is the first quantum-dot cellular automata design to perform B2G conversion and G2B in a single QCA circuit. The proposed designs are scalable. Specifications are reported.
The Ethics of ‘Deathbots’
Authors: Lindemann Nora Freya 
Published: November 2022

AbstractRecent developments in AI programming allow for new applications: individualized chatbots which mimic the speaking and writing behaviour of one specific living or dead person. ‘Deathbots’, chatbots of the dead, have already been implemented and are currently under development by the first start-up companies. Thus, it is an urgent issue to consider the ethical implications of deathbots. While previous ethical theories of deathbots have always been based on considerations of the dignity of the deceased, I propose to shift the focus on the dignity and autonomy of the bereaved users of deathbots. Drawing on theories of internet-scaffolded affectivity and on theories of grief, I argue that deathbots may have a negative impact on the grief process of bereaved users and therefore have the potential to limit the emotional and psychological wellbeing of their users. Deathbot users are likely to become dependent on their bots which may make them susceptible to surreptitious advertising by deathbot providing companies and may limit their autonomy. At the same time, deathbots may prove to be helpful for people who suffer from prolonged, severe grief processes. I caution against the unrestricted usage of deathbots and suggest that they should be classified as medical devices. This classification would not the least mean that their non-harm, as well as their helpfulness for people suffering from prolonged grief needs to be proven and that their potential for autonomy infringements is reduced.
A memetic procedure for global multi-objective optimization
Authors: Lapucci Matteo , Mansueto Pierluigi , Schoen Fabio 
Published: November 2022

AbstractIn this paper we consider multi-objective optimization problems over a box. Several computational approaches to solve these problems have been proposed in the literature, that broadly fall into two main classes: evolutionary methods, which are usually very good at exploring the feasible region and retrieving good solutions even in the nonconvex case, and descent methods, which excel in efficiently approximating good quality solutions. In this paper, first we confirm, through numerical experiments, the advantages and disadvantages of these approaches. Then we propose a new method which combines the good features of both. The resulting algorithm, which we call Non-dominated Sorting Memetic Algorithm, besides enjoying interesting theoretical properties, excels in all of the numerical tests we performed on several, widely employed, test functions.
Single cell profiling of γδ hepatosplenic T-cell lymphoma unravels tumor cell heterogeneity associated with disease progression
Authors: Song Wei , Zhang Haixi , Yang Fan , Nakahira Kiichi , Wang Cheng , Shi Keqian , Zhang Ruoyu 
Published: November 2022

Abstract
Purpose
Hepatosplenic T-cell lymphoma (HSTCL), mostly derived from γδ T cells, is a rare but very aggressive lymphoma with poor outcomes. In this study, we generated the first single cell landscape for this rare disease and characterized the molecular pathogenesis underlying the disease progression.

Methods
We performed paired single cell RNA-seq and T cell receptor (TCR) sequencing on biopsies from a HSTCL patient pre- and post- chemotherapy treatments. Following by a series of bioinformatics analysis, we investigated the gene expression profile of γδ HSTCS as well as its tumor microenvironment (TME).

Results
We characterized the unique gene expressing signatures of malignant γδ T cells with a set of marker genes were newly identified in HSTCL (AREG, PLEKHA5, VCAM1 etc.). Although the malignant γδ T cells were expanded from a single TCR clonotype, they evolved into two transcriptionally distinct tumor subtypes during the disease progression. The Tumor_1 subtype was dominant in pre-treatment samples with highly aggressive phenotypes. While the Tumor_2 had relative mild cancer hallmark signatures but expressed genes associated with tumor survival signal and drug resistance (IL32, TOX2, AIF1, AKAP12, CD38 etc.), and eventually became the main tumor subtype post-treatment. We further dissected the tumor microenvironment and discovered the dynamically rewiring cell–cell interaction networks during the treatment. The tumor cells had reduced communications with the microenvironment post-treatment.

Conclusions
Our study reveals heterogenous and dynamic tumor and microenvironment underlying pathogenesis of HSTCL and may contribute to identify novel targets for diagnosis and treatment of HSTCL in the future.
Practical workflow for assessment of seismic hazard in low enthalpy geothermal systems
Authors: Hettema Marc 
Published: November 2022

AbstractIt is of vital importance to be able to determine the seismic hazard in advance of any geothermal operation in the subsurface, especially in a densely populated area such as The Netherlands. The author aims to arrive at a practical assessment of the seismic hazard in low-enthalpy geothermal doublet systems specifically designed for heat exchange in porous and permeable aquifers operated on a volume balance, at a depth range of 1800 to 3300 m having temperatures in the range of 60 °C to 100 °C. The article presents a practical workflow aiming to determine the probability distribution for mechanical re-activation along pre-existing weak faults. After presenting the tectonic structural setting the criticality criterion based on shear mobilisation is introduced. Existing stress models are reviewed and a practical manner to estimate and limit all geomechanical input parameters is presented, including fault mechanical properties. The workflow is demonstrated both for early period operation times and at final thermal breakthrough. The uncertainty is addressed through probabilistic logic tree analysis quantifying the variation of the four most uncertain input parameters: fault cohesion and friction coefficient, the thermal stress parameter and the initial minimum Earth stress. The probabilistic hazard assessment is characterised by four output parameters: the expected value, the probability that unity is exceeded and two more probabilities. In case unity is exceeded the range of fault dips prone to mechanical re-activation is shown. Exceedance of this first necessary condition requires the assessment of the other two necessary conditions: seismogeneity and moment magnitude.Article highlightsThe article presents a practical workflow to assess the seismic hazard associated with geothermal operations.To be able to perform the necessary uncertainty analysis, four main input parameters are treated probabilistic.The first necessary condition for seismicity to occur is characterised by four probabilities: the expected probability, the probability that seismicity can occur and two higher probabilities.