bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pesticide exposure and lung cancer risk: A case-control study in Nakhon Sawan, Thailand
Authors: Kangkhetkron Teera , Juntarawijit Chudchawal 
Published: November 2022

Background: Pesticide exposure might increase risk of lung cancer. The purpose of this study was to investigate the association between the historical use of pesticides and lung cancer using a case-control design. Methods: This case-control study compared a lifetime pesticide exposure of 233 lung cancer cases, and 447 healthy neighbours matched for gender, and age (±5 years). Data on demographic, pesticide exposure and other related factors were collected using a face-to-face interview questionnaire. Associations between lung cancer and types of pesticides as well as individual pesticides were analysed using logistic regression adjusted for gender, age, cigarette smoking, occupation, cooking fumes exposure, and exposure to air pollution. Results: It was found that lung cancer was positively associated with lifetime use of herbicides and insecticides. Compared to people in the non-exposed groups, those in Q3-Q4 days of using herbicides and insecticides had an elevated risk of lung cancer, with odds ratio (OR) between 2.20 (95% confidence interval (CI) 1.24-3.89), and 3.99 (95% CI 1.62-7.11) (p < 0.001). For individual pesticides, those presenting a significant association with lung cancer were dieldrin (OR = 2.56; 95% CI 1.36-4.81), chlorpyrifos (OR = 3.29; 95 % CI 1.93-5.61), and carbofuran (OR = 2.10; 95% CI 1.28-3.42). It was also found, for the first time, carbofuran, glyphosate, and paraquat to be significantly associated with lung cancer. Conclusions: The results reconfirmed the association between pesticides exposure and lung cancer. In the study, five individual pesticides, e.g. dieldrin, chlorpyrifos, carbofuran, glyphosate, and paraquat were identified as a potential risk factors for the disease. More studies are still required to confirm the results and to identify more individual pesticides that could cause lung cancer. The issues should receive more attention since these chemicals are used widely.
Pancreatic cancer grading in pathological images using deep learning convolutional neural networks
Authors: Mohamad Sehmi Muhammad Nurmahir , Ahmad Fauzi Mohammad Faizal , Wan Ahmad Wan Siti Halimatul Munirah , Wan Ling Chan Elaine 
Published: November 2022

Background: Pancreatic cancer is one of the deadliest forms of cancer. The cancer grades define how aggressively the cancer will spread and give indication for doctors to make proper prognosis and treatment. The current method of pancreatic cancer grading, by means of manual examination of the cancerous tissue following a biopsy, is time consuming and often results in misdiagnosis and thus incorrect treatment. This paper presents an automated grading system for pancreatic cancer from pathology images developed by comparing deep learning models on two different pathological stains. Methods: A transfer-learning technique was adopted by testing the method on 14 different ImageNet pre-trained models. The models were fine-tuned to be trained with our dataset. Results: From the experiment, DenseNet models appeared to be the best at classifying the validation set with up to 95.61% accuracy in grading pancreatic cancer despite the small sample set. Conclusions: To the best of our knowledge, this is the first work in grading pancreatic cancer based on pathology images. Previous works have either focused only on detection (benign or malignant), or on radiology images (computerized tomography [CT], magnetic resonance imaging [MRI] etc.). The proposed system can be very useful to pathologists in facilitating an automated or semi-automated cancer grading system, which can address the problems found in manual grading.
Significant deterioration in quality of life and increased frailty in patients waiting more than six months for total hip or knee arthroplasty
Authors: Clement Nick D. , Wickramasinghe Neil R. , Bayram John M. , Hughes Katie , Oag Erlend , Heinz Nicholas , Fraser Ewen , Jefferies James G. , Dall Graham F. , Ballantyne Andy , Jenkins Paul J. 
Published: November 2022

Aims The primary aim of this study was to assess whether patients waiting six months or more for a total hip (THA) or knee (KA) arthroplasty had a deterioration in their health-related quality of life (HRQoL). Secondary aims were to assess changes in frailty and the number of patients living in a state considered to be worse than death (WTD), and factors associated with changes in HRQoL and frailty. Methods This cross-sectional study included 326 patients, 150 males (46.0%) and 176 females (54.0%), with a mean age of 68.6 years (SD 9.8) who were randomly selected from waiting lists at four centres and had been waiting for six months or more (median 13 months, interquartile range 10 to 21) for a primary THA (n = 161) or KA (n = 165). The EuroQol five-dimension questionnaire (EQ-5D) and visual analogue scores (EQ-VAS), Rockwood Clinical Frailty Scale (CFS), and 36-Item Short Form Survey subjective change in HRQoL were assessed at the time and recalled for six months earlier. A state that was WTD was defined as an EQ-5D of less than zero. Results There were significant deteriorations in the EQ-5D (mean 0.175, 95% confidence interval (CI) 0.145 to 0.204; p < 0.001), EQ-VAS (mean 8.6, 95% CI 7.0 to 10.4; < 0.001), and CFS (from 3 “managing well” to 4 “vulnerable”; p < 0.001), and a significant increase in the number of those in a state that was WTD (n = 48; p < 0.001) during the previous six months for the whole cohort. A total of 110 patients (33.7%) stated that their health was much worse and 107 (32.8%) felt it was somewhat worse compared with six months previously. A significantly greater EQ-5D (-0.14, 95% CI 0.08 to 0.28; p = 0.038) and a state that was not WTD (-0.14, 95% CI 0.01 to 0.26; p = 0.031) were associated with a deterioration in the EQ-5D. THA (0.21, 95% CI 0.07 to 0.34; p = 0.002) or a lower (better) CFS (0.14, 95% CI 0.07 to 0.20; p < 0.001) were independently significantly associated with a deterioration in the CFS. Conclusion Patients waiting more than six months for THA or KA had a significant deterioration in their HRQoL and increased frailty, with two-thirds of patients feeling that their health had worsened. Cite this article: Bone Joint J 2022;104-B(11):1215–1224.
Systemic administration with melatonin in the daytime has a better effect on promoting osseointegration of titanium rods in ovariectomized rats
Authors: Zhou Mao-Sheng , Tao Zhou-Shan 
Published: November 2022

Aims This study examined whether systemic administration of melatonin would have different effects on osseointegration in ovariectomized (OVX) rats, depending on whether this was administered during the day or night. Methods In this study, a titanium rod was implanted in the medullary cavity of one femoral metaphysis in OVX rats, and then the rats were randomly divided into four groups: Sham group (Sham, n = 10), OVX rat group (OVX, n = 10), melatonin day treatment group (OVX + MD, n = 10), and melatonin night treatment group (OVX + MN, n = 10). The OVX + MD and OVX + MN rats were treated with 30 mg/kg/day melatonin at 9 am and 9 pm, respectively, for 12 weeks. At the end of the research, the rats were killed to obtain bilateral femora and blood samples for evaluation. Results Micro-CT and histological evaluation showed that the bone microscopic parameters of femoral metaphysis trabecular bone and bone tissue around the titanium rod in the OVX + MD group demonstrated higher bone mineral density, bone volume fraction, trabecular number, connective density, trabecular thickness, and lower trabecular speculation (p = 0.004) than the OVX + MN group. Moreover, the biomechanical parameters of the OVX + MD group showed higher pull-out test and three-point bending test values, including fixation strength, interface stiffness, energy to failure, energy at break, ultimate load, and elastic modulus (p = 0.012) than the OVX + MN group. In addition, the bone metabolism index and oxidative stress indicators of the OVX + MD group show lower values of Type I collagen cross-linked C-telopeptide, procollagen type 1 N propeptide, and malondialdehyde (p = 0.013), and higher values of TAC and SOD (p = 0.002) compared with the OVX + MN group. Conclusion The results of our study suggest that systemic administration with melatonin at 9 am may improve the initial osseointegration of titanium rods under osteoporotic conditions more effectively than administration at 9 pm. Cite this article: Bone Joint Res 2022;11(11):751–762.
Retention, mobility, and successful transition to independence of health sciences postdocs
Authors: Shaaban C. Elizabeth , Dennis Tammy L. , Gabrielson Stephen , Miller Laura J. , Zellers Darlene F. , Levine Arthur S. , Rosano Caterina 
Published: November 2022

Introduction
Obtaining a tenure track faculty position (TTFP) after postdoctoral appointment (PDA) completion is considered an indicator of successful transition to independence (TTI). Whether cross-institutional mobility (CIM)—moving to a different institution from that of the PDA—contributes to TTI is unclear, as data evaluating retention and mobility is lacking. We tested the hypothesis that, for postdocs (PDs) at R1 institutions, CIM is a significant predictor of successful TTI defined as TTFP-status 3 years post-PDA.

Materials and methods
Using University of Pittsburgh data for health sciences PDs we tested the association of CIM at PDA completion (moved to a different institution (CIM = 1) or retained at Pitt (CIM = 0)) with TTFP-status 3 years post-PDA (TTFP, non-TTFP, or left faculty position) using multinomial logistic regression models.

Results
Among all 622 Pitt PDs, 3-year retention in a faculty position at Pitt was 21%, while 14% had a faculty position outside of Pitt. Among the analytic sample of PDs with an academic career outcome during the study period (N = 238; 50% women, 8% underrepresented minorities (URM)), at baseline PDA completion 39% moved to a different institution (CIM = 1), and 61% remained at Pitt (CIM = 0) in any job type. Those with CIM = 1 had greater odds of having a TTFP at follow-up than those with CIM = 0 [adjusted OR (95% CI): 4.4 (2.1, 9.2)].

Discussion
One fifth of Pitt PDs were retained by Pitt as faculty. While Pitt PDs were equally likely to get a faculty position whether they were retained at Pitt or left, those who left had greater odds of obtaining a TTFP. Future work with longer follow-up times, expanded markers of TTI, and samples from other R1 institutions is needed to better understand the reason for these results. This knowledge can lead to better support for the next generation of PDs as they successfully transition to faculty.
Changes in the proverb formula in Finnish Bibles from 1642 to 1992
Authors: Priiki Katri 
Published: November 2022

Abstract
The article studies a subtype of the Finnish generalizing relative clause, referred to as the proverb formula. A generalizing relative clause refers to any person who fills the described condition. The proverb formula is used frequently in the Finnish translations of the Bible in the Book of Proverbs. The study examines two aspects that vary in this structure in Finnish editions from 1642 to 1992: the head pronoun of the relative clause and the order of the relative clause and the main clause. In the oldest of the studied translations, the most frequent one variant or the proverb formula begins with the relative clause, and the relative clause head in the main clause is a personal pronoun (hän). For the order of the structure, a clear model is found in the source texts of the translation. In later editions, personal pronoun heads were eliminated. Interestingly, they are not replaced with demonstrative heads, which would follow the most frequent proverb formula structure in Finnish vernacular and would also be recommenced by grammar guides. Instead, a variant with omission of the head pronoun gains in frequency. Variations within the proverb formula increase when the order with the main clause preceding the relative clause gains in frequency. The preference for omission of the head pronouns is not easily explainable. The article proposes that this variant was a conscious stylistic choice for solemn, biblical language.
Impact on neonatal morbidities after a change in policy to administer antenatal corticosteroids to mothers at risk for late preterm delivery
Authors: Mally Pradeep , Katz Julia , Verma Sourabh , Purrier Sheryl , Wachtel Elena V. , Trillo Rebecca , Bhutada Kiran , Bailey Sean M. 
Published: November 2022

Abstract

Objectives
Antenatal corticosteroids (ACS) administered to mothers at risk for preterm delivery before 34 weeks has been standard care to improve neonatal outcomes. After introducing a new obstetric policy based on updated recommendations advising the administration of ACS to pregnant women at risk for late preterm (LPT) delivery (34–36 6/7 weeks), we set out to determine the short-term clinical impact on those LPT neonates.

Methods
Retrospective chart review of LPT neonates delivered at NYU Langone Medical Center both one year before and after the policy went into place. We excluded subjects born to mothers with pre-gestational diabetes, multiple gestations, and those with congenital/genetic abnormalities. We also excluded subjects whose mothers already received ACS previously in pregnancy. Subjects were divided into pre-policy and post-policy groups. Neonatal and maternal data were compared for both groups.

Results
388 subjects; 180 in the pre-policy and 208 in the post-policy group. This policy change resulted in a significant increase in ACS administration to mothers who delivered LPT neonates (67.3 vs. 20.6%, p<0.001). In turn, there was a significant reduction in LPT neonatal intensive care unit (NICU) admissions (44.2 vs. 54.4%, p=0.04) and need for respiratory support (27.9 vs. 42.8%, p<0.01). However, we also found an increased incidence of hypoglycemia (49.5 vs. 28.3%, p<0.001).

Conclusions
This LPT ACS policy appears effective in reducing the need for LPT NICU level care overall. However, clinicians must be attentive to monitor for adverse effects like hypoglycemia, and there remains a need for better understanding of potential long-term impacts.
Parameter least-squares estimation for time-inhomogeneous Ornstein–Uhlenbeck process
Authors: Pramesti Getut 
Published: November 2022

Abstract
We address the least-squares estimation of the drift coefficient parameter

θ
=

(
λ
,
A
,
B
,

ω
p

)

\theta=(\lambda,A,B,\omega_{p})

of a time-inhomogeneous Ornstein–Uhlenbeck process that is observed at high frequency, in which the discretized step size ℎ satisfies

h
→
0

h\to 0

.
In this paper, under the conditions

n
⁢
h

→
∞

nh\to\infty

and

n
⁢

h
2

→
0

nh^{2}\to 0

, we prove the consistency and the asymptotic normality of the estimators.
We obtain the convergence of the parameters at rate

n
⁢
h

\sqrt{nh}

, except for

ω
p

\omega_{p}

at

n
3

⁢

h
3

\sqrt{n^{3}h^{3}}

.
To verify our theoretical findings, we do a simulation study.
We then illustrate the use of the proposed model in fitting the energy use of light fixtures in one Belgium household and the stock exchange.
Functional Intraregional and Interregional Heterogeneity between Myenteric Glial Cells of the Colon and Duodenum in Mice
Authors: Seguella Luisa , McClain Jonathon L. , Esposito Giuseppe , Gulbransen Brian D. 
Published: November 2022

Enteric glia are a unique population of peripheral neuroglia that regulate homeostasis in the enteric nervous system (ENS) and intestinal functions. Despite existing in functionally diverse regions of the gastrointestinal tract, enteric glia have been approached scientifically as a homogeneous group of cells. This assumption is at odds with the functional specializations of gastrointestinal organs and recent data suggesting glial heterogeneity in the brain and ENS. Here, we used calcium imaging in transgenic mice of both sexes expressing genetically encoded calcium sensors in enteric glia and conducted contractility studies to investigate functional diversity among myenteric glia in two functionally distinct intestinal organs: the duodenum and the colon. Our data show that myenteric glia exhibit regionally distinct responses to neuromodulators that require intercellular communication with neurons to differing extents in the duodenum and colon. Glia regulate intestinal contractility in a region-specific and pathway-specific manner, which suggests regionally diverse engagement of enteric glia in local motor patterns through discrete signaling pathways. Further, functional response profiles delineate four unique subpopulations among myenteric glia that are differentially distributed between the colon and duodenum. Our findings support the conclusion that myenteric glia exhibit both intraregional and interregional heterogeneity that contributes to region-specific mechanisms that regulate digestive functions. Glial heterogeneity adds an unexpected layer of complexity in peripheral neurocircuits, and understanding the specific functions of specialized glial subtypes will provide new insight into ENS physiology and pathophysiology.SIGNIFICANCE STATEMENTEnteric glia modulate gastrointestinal functions through intercellular communication with enteric neurons. Whether heterogeneity exists among neuron–glia interactions in the digestive tract is not understood. Here, we show that myenteric glia display regional heterogeneity in their responses to neuromodulators in the duodenum and the colon, which are functionally distinct organs. Glial-mediated control of intestinal motility is region and pathway specific. Four myenteric glial subtypes are present within a given gut region that are differently distributed between gut regions. These data provide functional and regional insights into enteric circuit specificity in the adult enteric nervous system.
The Health-Seeking Behavior of Diabetes Mellitus Patients during the COVID-19 Pandemic in Brebes Regency
Authors: Faisal Hiro Putra , Adiyatma Chrestella , Tyastuti Dwi 
Published: November 2022

Background: The COVID-19 pandemic in Indonesia has impacted patients with non-communicable diseases such as Diabetes Mellitus (DM). The impacts include health services, treatment management, and patients' health-seeking behavior. This study aims to determine the DM patients' health-seeking behavior in the Salem sub-district, Brebes district, Central Java.Methods: This research was a qualitative descriptive study conducted cross-sectionally using a survey. The purposive sampling technique was employed to obtain the data with a total sample of 106 respondents.Results: Most DM patients still visited health facilities during the pandemic (73%). Some efforts to control DM were regularly taking medication (27.7%) and maintaining a healthy diet (34%). However, most respondents stated that they have uncontrolled blood glucose levels (54.7%). During the pandemic, respondents communicated with health workers (75.5%), via telephone (64.2%), and through messaging applications (45.3%). In addition, they search information, especially when they felt symptoms (90.6%), and tried to find information about complications due to the coronavirus (68.9%) with the source from health workers (94.3%). Most respondents had good access (99.1%).Conclusion: The COVID-19 pandemic has resulted changes in DM patients' health-seeking behavior through all aspects. This study shows that most respondents visited health facilities, made efforts to control DM by taking the medication regularly and maintaining a healthy diet, and had high adherence to medication. In addition, respondents had an easy access to health information and communicate with health workers via telephone and messaging applications. The majority of respondents sought information about diabetes and its relationship with COVID-19 during the pandemic.
MATHEMATICAL MODELING OF THE STRENGTH OF HETEROGENEOUS GEL FORMING SYSTEMS BASED ON GELLING AGENTS OF POLYSACCHARIDE AND PROTEIN ORIGINS
Authors: Foshchan A. , Yevlash V. , Potapov V. 
Published: November 2022

This paper is devoted to solving an important task of the food industry - the rational use of food raw materials, including gelling agents of various origins. The innovative strategy of this study is based on the possibility of using gelatin and modified potato or pea starch, as a cheap ingredient in the production of gel semi-finished products and confectionery based on traditional, but expensive raw materials such as agar and agar from Furcellaria - furcelaran. Food gelatin (Ukraine), agar (Germany), furcelaran (Estonia), modified potato starch OPV-1 (Ukraine), modified potato starch Farinex VA-40 (Netherlands), modified pea starch Emden ESH-15 (Germany) were used in the work. The experimental study has been performed concerning the strength of gel-forming heterogeneous systems ‘gelatin - MS - agar – water’ and ‘gelatin - MS - fercellaran – water’, and homogeneous systems: ‘agar - water’, ‘fursalaran - water’, ‘gelatin – water’. Mathematical models have been obtained that relate the strength of the investigated gel-forming systems to the mass concentration of their components. The equation has been obtained that allows calculating the mass concentration of the components of the studied gel-forming compositions with the given level of strength of systems. It is shown that for a given level of strength of a heterogeneous gel-forming system there is an optimal concentration of its components in terms of the least full cost of the system. The equation that allows to calculate the optimal concentration of components of a heterogeneous gel-forming system has been obtained. The adequate mathematical model for forecasting the strength of modelling systems of gel-forming, depending on the mass concentration of components is obtained. It is envisaged to formulate the initial requirements for the parameters of gel-forming, which will allow obtaining an integral elastic structure at optimum duration of the technological process, by modelling the systems of gel-forming, as a technological system, within the framework of the functioning of individual subsystems (the creation of prescription concentrations and ratios of gel-forming agents). The obtained mathematical models can be used for the analysis of other heterogeneous gel-forming compositions in the presence of the data on the strength of such systems depending on the concentration of components.