bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review and meta-analysis on the therapeutic reference range for escitalopram: Blood concentrations, clinical effects and serotonin transporter occupancy
Authors: Eichentopf Luzie , Hiemke Christoph , Conca Andreas , Engelmann Jan , Gerlach Manfred , Havemann-Reinecke Ursula , Hefner Gudrun , Florio Vincenzo , Kuzin Maxim , Lieb Klaus , Reis Margareta , Riemer Thomas G. , Serretti Alessandro , Schoretsanitis Georgios , Zernig Gerald , Gründer Gerhard , Hart Xenia M. 
Published: October 2022

IntroductionA titration within a certain therapeutic reference range presupposes a relationship between the blood concentration and the therapeutic effect of a drug. However, this has not been systematically investigated for escitalopram. Furthermore, the recommended reference range disagrees with mean steady state concentrations (11–21 ng/ml) that are expected under the approved dose range (10–20 mg/day). This work systematically investigated the relationships between escitalopram dose, blood levels, clinical effects, and serotonin transporter occupancy.MethodsFollowing our previously published methodology, relevant articles were systematically searched and reviewed for escitalopram.ResultsOf 1,032 articles screened, a total of 30 studies met the eligibility criteria. The included studies investigated escitalopram blood levels in relationship to clinical effects (9 studies) or moderating factors on escitalopram metabolism (12 studies) or serotonin transporter occupancy (9 studies). Overall, the evidence for an escitalopram concentration/effect relationship is low (level C).ConclusionBased on our findings, we propose a target range of 20–40 ng/ml for antidepressant efficacy of escitalopram. In maintenance treatment, therapeutic response is expected, when titrating patients above the lower limit. The lower concentration threshold is strongly supported by findings from neuroimaging studies. The upper limit for escitalopram’s reference range rather reflects a therapeutic maximum than a tolerability threshold, since the incidence of side effects in general is low. Concentrations above 40 ng/ml should not necessarily result in dose reductions in case of good clinical efficacy and tolerability. Dose-related escitalopram concentrations in different trials were more than twice the expected concentrations from guideline reports.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=215873], identifier [CRD42020215873].
The knowledge, attitudes and practices of hand, foot, and mouth disease prevention strategies amongst parents and educators of children under 5 years amidst COVID-19 pandemic: A cross-sectional study
Authors: Wang Min Xian , Pang Junxiong 
Published: October 2022

BackgroundHand, foot, and mouth disease (HFMD) is endemic in Singapore. Prevention efforts have been ramped up since major outbreaks in the early 2000's. This study aims to assess the current knowledge, and attitudes towards and practise (KAP) levels of HFMD prevention strategies (HFMD-PS) amongst parents and teachers of children under 5 years amidst the COVID-19 pandemic.Methods and resultsA convenience sample of 240 teachers and 404 parents responded to a self-administered standardised questionnaire between mid-October and December 2020. A scoring framework was used to assess responses in the ‘knowledge', ‘attitude', and ‘practice' domains. A multivariable analysis was adjusted for ethnicity and attitudes towards getting children to follow proper handwashing steps and regularly disinfecting children's toys amongst parents, knowledge about HFMD's infectious period, and the responses to a child turning symptomatic in the childcare centre amongst teachers. Existing levels of knowledge and attitudes of parents and teachers were not high, and only a small proportion practised high levels of prevention measures (99 parents and 28 teachers). Key facilitators for a higher practise level in parents include the following: (1) awareness of regular liquid soap's efficacy as a disinfectant, (2) toy cleaning before and after playtime, and (3) the cleaning agent used for this practise. Teachers had no significant factors associated with higher practise levels.ConclusionThis study suggested potential gaps between positive knowledge and attitudes towards prevention strategies and their actual adoption levels in homes and childcare centres during COVID-19 pandemic. These evidences suggest the importance of continuous promotion of HFMD prevention practise in homes and childcare centres, even amidst pandemics.
The safety and feasibility of laparoscopic right posterior sectionectomy vs. open approach: A systematic review and meta-analysis
Authors: Wang Meng-Xiao , Xiang Ji-Feng , Chen Sheng-Kai , Xiao Lin-Kang 
Published: October 2022

BackgroundLaparoscopic right posterior sectionectomy (LRPS) is one of the most technically challenging and potentially hazardous procedures in laparoscopic liver resection. Although some available literature works demonstrated the safety and feasibility of LRPS, these data are limited to reports from a single institution and a small sample size without support from evidence-based medicine. So, we performed a meta-analysis to assess further the safety and feasibility of LRPS by comparing it with open right posterior sectionectomy (ORPS).MethodsMEDLINE, Embase, and Cochrane Library were systematically searched for eligible studies comparing LRPS and open approaches. Random and fixed-effects models were used to calculate outcome measures.ResultsFour studies involving a total of 541 patients were identified for inclusion: 250 in the LRPS group and 291 in the ORPS group. The postoperative complication and margin were not statistically different between the two groups (OR: 0.49, 95% CI: 0.18 to 1.35, P = 0.17) (MD: 0.05, 95% CI: −0.47 to 0.57, P = 0.86), respectively. LRPS had a significantly longer operative time and shorter hospital stay (MD: 140.32, 95% CI: 16.73 to 263.91, P = 0.03) (MD: −1.64, 95% CI: −2.56 to −0.72, P = 0.0005) respectively.ConclusionData from currently available literature suggest that LRPS performed by an experienced surgeon is a safe and feasible procedure in selected patients and is associated with a reduction in the hospital stay.
Comprehensive clinical analysis of patients with primary malignant tumor of pituitary gland: A population-based study
Authors: Sun Xu , Huo Lanqing , Wang Xin , Zhang Chunlan , Zhao Ailin 
Published: October 2022

Background and ObjectivesThis study aims to perform a comprehensive clinical analysis of patients with primary malignant pituitary tumors (PMPT) that involves incidence, demographics, treatments, long-term survival, and death causes.Materials and methodsPatients with PMPT were identified from registries of the Surveillance, Epidemiology, and End Results (SEER) database. Frequencies and average annual age-adjusted rate (AAR) were calculated for incidence trend analyses using Join-point regression. Univariate and multivariate Cox regression analyses were conducted to identify potential prognostic factors associated with patients' survival outcomes. Using the Kaplan–Meier method and log-rank test, survival curves were plotted and compared, respectively. Propensity score matching (PSM) was performed to balance baseline characteristics.ResultsThe AAR for PMPT was 0.233 (95%CI: 0.205–0.264) per 1,000,000 using nine SEER registries from 1975 to 2017. The incidence trend has declined over years but without significance (–1.04% per year, P = 0.10). Besides, older age may indicate a higher incidence rate for both pediatric and adult patients. From 18 SEER registries, a total of 501 PMPT patients were also identified. Univariate and multivariate Cox regression showed age, sex, tumor extent, and marital status were independent prognostic factors for malignant pituitary tumors. Via PSM, we found that patients who received surgery, radiotherapy, and chemotherapy did not demonstrate significantly different survival than those who did not.ConclusionThis study first conducts a comprehensive clinical analysis of patients with PMPT and provides guide effects on future study designs. More studies should be conducted to focus on its characteristics and therapy.
Survival Prediction of Glioma Patients from Integrated Radiology and Pathology Images Using Machine Learning Ensemble Regression Methods
Authors: Rathore Faisal Altaf , Khan Hafiz Saad , Ali Hafiz Mudassar , Obayya Marwa , Rasheed Saim , Hussain Lal , Kazmi Zaki Hassan , Nour Mohamed K. , Mohamed Abdullah , Motwakel Abdelwahed 
Published: October 2022

Gliomas are tumors of the central nervous system, which usually start within the glial cells of the brain or the spinal cord. These are extremely migratory and diffusive tumors, which quickly expand to the surrounding regions in the brain. There are different grades of gliomas, hinting about their growth patterns and aggressiveness and potential response to the treatment. As part of routine clinical procedure for gliomas, both radiology images (rad), such as multiparametric MR images, and digital pathology images (path) from tissue samples are acquired. Each of these data streams are used separately for prediction of the survival outcome of gliomas, however, these images provide complimentary information, which can be used in an integrated way for better prediction. There is a need to develop an image-based method that can utilise the information extracted from these imaging sequences in a synergistic way to predict patients’ outcome and to potentially assist in building comprehensive and patient-centric treatment plans. The objective of this study is to improve survival prediction outcomes of gliomas by integrating radiology and pathology imaging. Multiparametric magnetic resonance imaging (MRI), rad images, and path images of glioma patients were acquired from The Cancer Imaging Archive. Quantitative imaging features were extracted from tumor regions in rad and path images. The features were given as input to an ensemble regression machine learning pipeline, including support vector regression, AdaBoost, gradient boost, and random forest. The performance of the model was evaluated in several configurations, including leave-one-out, five-fold cross-validation, and split-train-test. Moreover, the quantitative performance evaluations were conducted separately in the complete cohort (n = 171), high-grade gliomas (HGGs), n = 75, and low-grade gliomas (LGGs), n = 96. The combined rad and path features outperformed individual feature types in all the configurations and datasets. In leave-one-out configuration, the model comprising both rad and path features was successfully validated on the complete dataset comprising HGFs and LGGs (R=0.84 p=2.2×10−16). The Kaplan–Meier curves generated on the predictions of the proposed model yielded a hazard ratio of 3.314 [95%CI:1.718−6.394], log−rank(P)=2×10−4 on combined rad and path features. Conclusion: The proposed approach emphasizes radiology experts and pathology experts’ clinical workflows by creating prognosticators upon ‘rad’ radiology images and digital pathology ‘path’ images independently, as well as combining the power of both, also through delivering integrated analysis, that can contribute to a collaborative attempt between different departments for administration of patients with gliomas.
Molecular Epidemiological Investigation of Piroplasms and Anaplasmataceae Bacteria in Egyptian Domestic Animals and Associated Ticks
Authors: Abdel-Shafy Sobhy , Abdullah Hend H. A. M. , Elbayoumy Mohamed K. , Elsawy Bassma S. M. , Hassan Mohamed R. , Mahmoud Mona S. , Hegazi Ahmed G. , Abdel-Rahman Eman H. 
Published: October 2022

Piroplasmosis and anaplasmosis are serious tick-borne diseases (TBDs) that are concerning for the public and animal health. This study aimed to detect the molecular prevalence and epidemiological risk factors of Piroplasma and Anaplasma species in animal hosts and their associated ticks in Egypt. A total of 234 blood samples and 95 adult ticks were collected from animal hosts (112 cattle, 38 sheep, 28 goats, 26 buffaloes, 22 donkeys, and 8 horses) from six provinces of Egypt (AL-Faiyum, AL-Giza, Beni-Suef, Al-Minufia, Al-Beheira, and Matruh). Blood and tick samples were investigated by polymerase chain reaction coupled with sequencing targeting 18S and 16S RNA genes for Piroplasma and anaplasmataceae, respectively. Statistical analysis was conducted on the potential epidemiological factors. Of the 234 animals examined, 54 (23.08%) were positive for pathogens DNA distributed among the six provinces, where 10 (4.27%) were positive for Piroplasma, 44 (18.80%) for anaplasmataceae, and 5 (2.14%) were co-infected. Co-infections were observed only in cattle as Theileria annulata and Anaplasma marginale plus Babesia bigemina, A. marginale plus B. bigemina, and T. annulata plus B. bigemina. Piroplasmosis was recorded in cattle, with significant differences between their prevalence in their tick infestation factors. Animal species, age, and tick infestation were the potential risk factors for anaplasmosis. All ticks were free from piroplasms, but they revealed high prevalence rates of 72.63% (69/95) with anaplasmataceae. We identified T. annulata, B. bigemina, and A. marginale in cattle; A. platys in buffaloes; A. marginale and A. ovis in sheep; for the first time, A. ovis in goats; and Ehrlichia sp. in Rhipicephalus annulatus ticks. Our findings confirm the significant prevalence of piroplasmosis and anaplasmosis among subclinical and carrier animals in Egypt, highlighting the importance of the government developing policies to improve animal and public health security.
The Tube-Web Spiders of the Genus Ariadna (Araneae: Segestriidae) from South Australia and Victoria
Authors: Marsh Jessica R. , Stevens Mark I. , Bradford Tessa , Framenau Volker W. 
Published: October 2022

The tube-web spider genus Ariadna Audouin, 1826 has been revised for South Australia and Victoria, revealing a remarkable diversity, particularly centred in the arid north of South Australia. We describe 23 species as new, ten of which are supported by molecular data, where these were available. We recognise two species groups for some of the species based on a combination of genitalic morphology, macrosetae patterns and somatic characters: the clavata species group, which includes Ariadna clavata Marsh, Baehr, Glatz & Framenau, 2018 and A. spinosa sp. nov. from South Australia, and A. otwayensis sp. nov. and A. sinuosa sp. nov. from Victoria, and the formosa species group, including A. formosa sp. nov. and A. umbra sp. nov. from South Australia, and A. tria sp. nov. from Victoria. Seventeen new species could not be placed into these two species groups: A. arenacea sp. nov., A. bellatula sp. nov., A. curvata sp. nov., A. deserta sp. nov., A. diucrura sp. nov., A. flavescens sp. nov., A. inflata sp. nov., A. insula sp. nov., A. pollex sp. nov., A. propria sp. nov., A. rutila sp. nov., Ariadna simplex sp. nov., A. subplana sp. nov., A. una sp. nov., A. ungua sp. nov., A. valida sp. nov. and A. woinarskii sp. nov. We provide updated diagnoses and distributional data for A. clavata and A. tangara Marsh, Baehr, Glatz & Framenau, 2018; however, the holotype of A. burchelli (Hogg, 1900) from Victoria could not be located for this project.
Peran Serta Masyarakat dengan Angka Kejadian Diare
Authors: Nurhaedah Nurhaedah , Pannyiwi Rahmat , Suprapto Suprapto 
Published: October 2022

Pendahuluan: Diare merupakan salah satu penyebab paling umum dari morbiditas dan mortalitas anak, diperburuk oleh air yang tidak memadai, layanan sanitasi dan kebersihan, dan kekurangan gizi, terutama di negara-negara berkembang.
Tujuan: Mengetahui peran serta masyarakat dengan angka kejadian diare.
Metode: Desain penelitian kuantitatif menggunakan pendekatan analitik observasional dengan Cross Sectional. Jumlah sampel 69 orang, pengumpulan data wawancara mendalam, observasi, dan telaah dokumen, dianalisis univariat dan bivariat dengan bantuan SPSS versi 21.
Hasil: Menunjukan uji statistik chi-square diperoleh nilai p = 0,000 < 0,05 peran masyarakat.
Kesimpulan: Bahwa ada hubungan peran masyarakat dengan angka kejadian Diare. Oleh karena itu, dalam melakukan sosialisasi dan edukasi atau penyuluhan tentang kejadian Diare kepada seluruh masyarakat dengan bekerja sama dengan tenaga kesehatan sehingga bisa meningkatkan peran aktif masyarakat tentang kesehatan
Long wavelength red to green emissions from {11

2¯

2} semipolar multi-quantum wells on fully relaxed InGaN underlayer
Authors: Tawarazako Yuya , Nishi Naoya , Nakata Atsuto , Okada Narihito , Kurai Satoshi , Yamada Yoichi , Tadatomo Kazuyuki 
Published: October 2022

Abstract
In this study, we present {11

2

¯

2} InGaN underlayers of high In composition and multi-quantum wells (MQWs) grown using the m-plane sapphire substrate. Fully relaxed InGaN templates with high In composition (In: ∼18%) were investigated. We used an InGaN template with an In composition of 16.5%. The photoluminescence (PL) spectrum of MQWs on the InGaN template exhibited higher emission intensity and longer emission wavelength than that on a GaN template. Moreover, an InGaN barrier was found to be more suitable than a GaN barrier for the long-wavelength (red) region in the InGaN underlayer. The intensity of the PL spectrum of InGaN/InGaN MQWs was twice as high as that of InGaN/GaN MQWs in the red emission region. Finally, we analyzed the optical polarization of the MQWs on {11

2

¯

2} InGaN underlayers and its characteristics were discussed using theoretical equations.
Re-evaluation of energy dependence of electronic stopping cross-section for Al ions into 4H-SiC (0001)
Authors: Mochizuki Kazuhiro , Nishimura Tomoaki , Mishima Tomoyoshi 
Published: October 2022

Abstract
To apply channeled-ion implantation to cost-effective multi-epitaxial growth for 4H-SiC superjunction devices, we re-evaluated the Al-ion energy (E) dependence of the electronic stopping cross section (S
e) in 4H-SiC based on the recently reported secondary-ion mass spectrometry measured depth profiles. By including the effect of stripping of the ion electrons on the E dependence of S
e, we successfully reproduced the reported maximum channeled ranges of Al into 4H-SiC (0001), ranging from 0.6 μm at the implantation-energy (E
0) of 60 keV to 7.2 μm at E
0 of 8 MeV.
Using hard X-ray photoelectron spectroscopy to study a SiO2/HfO2-based interface dipole modulation stack embedded in a metal–insulator-metal structure
Authors: Kirihara Yoshiharu , Tsujiguchi Ryota , Ito Shunichi , Yasui Akira , Miyata Noriyuki , Nohira Hiroshi 
Published: October 2022

Abstract
Hard X-ray photoelectron spectroscopy was used to examine the interface dipole modulation of SiO2/1-monolayer titanium oxide/HfO2 stack embedded in a metal–insulator–metal structure. Reversible shifts in the Si 1 s, Hf 3d, and Ti 1 s photoelectron peaks were induced by electrical stress, and they indicate the switching of the potential profile inside the SiO2/titanium oxide/HfO2 stack. Moreover, a proportion change in the Ti3+ component correlates with the potential switching, and that correlation suggests that the structural change around the interface titanium atoms leads to the interface dipole modulation.
Similarity-based Multi-source Transfer Learning Approach for Time Series Classification
Authors: Senanayaka Ayantha , Al Mamun Abdullah , Bond Glenn , Tian Wenmeng , Wang Haifeng , Fuller Sara , Falls TC , Rahimi Shahram , Bian Linkan 
Published: October 2022

This study aims to develop an effective method of classification concerning time series signals for machine state prediction to advance predictive maintenance (PdM). Conventional machine learning (ML) algorithms are widely adopted in PdM, however, most existing methods assume that the training (source) and testing (target) data follow the same distribution, and that labeled data are available in both source and target domains. For real-world PdM applications, the heterogeneity in machine original equipment manufacturers (OEMs), operating conditions, facility environment, and maintenance records collectively lead to heterogeneous distribution for data collected from different machines. This will significantly limit the performance of conventional ML algorithms in PdM. Moreover, labeling data is generally costly and time-consuming. Finally, industrial processes incorporate complex conditions, and unpredictable breakdown modes lead to extreme complexities for PdM. In this study, similarity-based multi-source transfer learning (SiMuS-TL) approach is proposed for real-time classification of time series signals. A new domain, called "mixed domain," is established to model the hidden similarities among the multiple sources and the target. The proposed SiMuS-TL model mainly includes three key steps: 1) learning group-based feature patterns, 2) developing group-based pre-trained models, and 3) weight transferring. The proposed SiMuS-TL model is validated by observing the state of the rotating machinery using a dataset collected on the Skill boss manufacturing system, publicly available standard bearing datasets, Case Western Reserve University (CWRU), and Paderborn University (PU) bearing datasets. The results of the performance comparison demonstrate that the proposed SiMuS-TL method outperformed conventional Support Vector Machine (SVM), Artificial Neural Network (ANN), and Transfer learning with neural networks (TLNN) without similarity-based transfer learning methods.
Holey SIW Horn Antenna Based on an H-plane Lens-wise Wavefront Collimation
Authors: Biedma-Pérez Andrés , Padilla Pablo , Segura-Gómez Cleofás , Palomares-Caballero Ángel 
Published: October 2022

<p>This paper presents an H-plane SIW horn antenna whose directivity is enhanced using holey unit cells along the horn flaring. By wisely drilling the horn antenna, it is possible to reduce the phase error in the aperture which is a common problem in horn antennas if the optimum dimensions are not employed. An analysis of the distribution of the unit cells along the horn antenna has been carried out to achieve the desired equivalent refractive indices. By changing the hole radius, different equivalent refractive indices can be tuned with a wideband performance. This fact enables the implementation of a collimation zone inside the horn antenna which transforms the pseudo-circular wavefront into a quasi-planar one in the radiating aperture. The produced directivity is similar to the horn antenna with the optimum dimensions but a longitudinal reduction of 53.7% and a higher realized gain are achieved. A holey SIW horn antenna is designed and manufactured. The measured results show an impedance bandwidth performance below -10 dB from 34.3 GHz to 44.5 GHz (25.9%) with a realized gain above 10 dBi. The gain difference regarding a SIW horn antenna without the collimation zone is about 2-3 dBi in the operating frequency range. </p>