bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender inequality in PGY1 residency leadership positions and conferral of health-system pharmacy professional awards
Authors: Payne-Cardona Monique , Arnold Lindsay M , Jaiprasert Sorraya , Leonard Joy , Panahi Sara , Farrell Natalija M 
Published: March 2022

Abstract

Purpose
To address gender inequality, the American Society of Health-System Pharmacists (ASHP) created a steering committee that recommended the collection of baseline and ongoing metrics of pharmacy leadership. The purpose of this study was to quantify gender inequality in distributions of residency program director (RPD) and director of pharmacy (DOP) positions and to investigate gender distributions among recipients of ASHP professional leadership awards.

Methods
RPD and DOP information for postgraduate year 1 (PGY1) programs included in the online ASHP residency directory were collected in December of 2020. Publicly available records were used to collect information on recipients of the Harvey A.K. Whitney Award and John W. Webb Award during the periods 1950-2020 and 1985-2020, respectively. Gender information for RPDs, DOPs, and award recipients was collected from listed pronouns available in public records. A χ 2 test was used for analysis of the collected data.

Results
A total of 1,176 PGY1 residency programs were included. Of the RPD positions assessed, 66% (n = 775) were filled by women pharmacists (P &lt; 0.0001), while the percentage of DOP leadership positions held by women was 42% (n = 496) (P &lt; 0.0001). Evaluation of data on recipients of the Harvey A.K. Whitney Award and John W. Webb Award revealed the occurrence of female recipients is 19.7% (n = 14) and 16.7% (n = 6), respectively (P &lt; 0.0001).

Conclusion
RPD positions have a higher prevalence of being filled by women. DOP positions remain male-dominated and revealed gender inequality among senior-level leadership roles. Pharmacy leadership award analysis identified further gender inequality. The results from the study serve as a baseline of current gender metrics for pharmacy leaderships in hospital systems with PGY1 residency programs.
Reimagining cholinergic therapy for Alzheimer’s disease
Authors: Giacobini Ezio , Cuello A Claudio , Fisher Abraham 
Published: March 2022

AbstractCurrently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors represents the main available approach to treat cognitive and behavioural symptoms of the early as well as late stages of Alzheimer’s disease. Restoring the cholinergic system has been a primary means of improving cognition in Alzheimer’s disease, as four of the six approved therapies are acetylcholinesterase inhibitors.Memantine is an N-methyl-d-aspartate antagonist with a well-documented clinical effect on behavioural symptoms, which is often added to cholinesterase inhibitors to potentiate their effect and aducanumab, targeting the amyloid pathology, has recently been approved.The early, progressive and selective degeneration of the cholinergic system together and its close relation to cognitive deficits supports the use of cholinergic therapy for Alzheimer’s disease.This review provides an updated view of the basal forebrain cholinergic system, its relation to cognition and its relevance for therapy of Alzheimer’s disease. It deals with the three main aspects that form the basis of the cholinergic-oriented therapy of Alzheimer’s disease, its origin, its mechanism of action, its clinical effects, advantages and limits of a cholinergic therapeutic approach. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer’s disease as well as the recent development of new and highly selective M1 muscarinic receptor agonists with disease-modifying potential. It also addresses the discovery of a novel nerve growth factor metabolic pathway responsible for the trophic maintenance of the basal forebrain system and its deregulation in Alzheimer’s disease. It discusses new clinical studies and provides evidence for the long-term efficacy of cholinesterase inhibitor therapy suggesting a disease-modifying effect of these drugs.The classical symptomatic cholinergic therapy based on cholinesterase inhibitors is judiciously discussed for its maximal efficacy and best clinical application. The review proposes new alternatives of cholinergic therapy that should be developed to amplify its clinical effect and supplement the disease-modifying effect of new treatments to slow down or arrest disease progression.
Digitalization, Digitization and Datafication: The "Three D" Transformation of Forced Migration Management
Authors: Witteborn Saskia 
Published: March 2022

AbstractDigitalization, digitization, and datafication—referred to as the three Ds transforming forced migration management—are composed of practices of abstraction which constitute socio-spatial processes and the imaginary supporting these processes. Against the backdrop of migration management initiatives in Germany and in the European Union, the article highlights how practices like data sharing and predictive modeling create a space of abstraction which is consolidated by the imaginary of quantification and automation. This space and imaginary, based on the premises of efficiency, transparency, and control and actualized by a technocratic apparatus, define the management of migration as well as the figure of the migrant. The article concludes that the three Ds will increasingly shape forced migrants’ lives through the leveling logics of technocratic control. Academic attention to data ownership and data justice is more important than ever.
Ethnography of community governance: a case of COVID-19 response of an urban slum in Bangladesh
Authors: Zaman Shahaduz , Hossain Faruq , Matin Imran 
Published: March 2022

Abstract
Although COVID-19 cases and deaths in different clusters of Bangladesh were increasing rapidly for most of the year 2020, surprisingly very few cases were reported in the urban slums, identified as the potential hotspots of Coronavirus. While the epidemiological puzzle of the low incidence of COVID-19 in slums remains unresolved, an ethnography in an urban slum in Dhaka, the capital city of Bangladesh, reveals how, in the context of indifference from the state, the slum dwellers themselves initiated several informal but robust interventions to tackle the pandemic. This study reveals the power of community governance from below, which we understand using Bayat’s (2013) concept of ‘quiet encroachment’ and Roy’s (2009) argument about the role of informality in urban governance. To adapt to the pandemic situation, we applied an innovative ‘peer research’ approach for data collection.
Distinct functional levels of human voice processing in the auditory cortex
Authors: Staib Matthias , Frühholz Sascha 
Published: March 2022

AbstractVoice signaling is integral to human communication, and a cortical voice area seemed to support the discrimination of voices from other auditory objects. This large cortical voice area in the auditory cortex (AC) was suggested to process voices selectively, but its functional differentiation remained elusive. We used neuroimaging while humans processed voices and nonvoice sounds, and artificial sounds that mimicked certain voice sound features. First and surprisingly, specific auditory cortical voice processing beyond basic acoustic sound analyses is only supported by a very small portion of the originally described voice area in higher-order AC located centrally in superior Te3. Second, besides this core voice processing area, large parts of the remaining voice area in low- and higher-order AC only accessorily process voices and might primarily pick up nonspecific psychoacoustic differences between voices and nonvoices. Third, a specific subfield of low-order AC seems to specifically decode acoustic sound features that are relevant but not exclusive for voice detection. Taken together, the previously defined voice area might have been overestimated since cortical support for human voice processing seems rather restricted. Cortical voice processing also seems to be functionally more diverse and embedded in broader functional principles of the human auditory system.
“Cheap Talk” in International Trade Law
Authors: Park Tae Jung 
Published: March 2022

Abstract
There is a dilemma in the field of international trade law: Many negotiating countries fail to complete treaties during the renegotiation period.1 Due to tight schedules in the primary negotiation, the parties normally insert a renegotiation clause to postpone completion of a treaty. However, the parties frequently postpone the completion of the treaty even in the renegotiation phase. The literature has neglected to consider the existence and causes of these issues, as well as the solutions to them. This article aims to remedy this neglect.
Patterns of Labour Market Adjustment to Trade Shocks with Imperfect Capital Mobility
Authors: Artuc Erhan , Brambilla Irene , Porto Guido 
Published: March 2022

Abstract
We explore how different investment frictions affect the patterns of responses of labour markets to tariff cuts. To investigate these patterns, we formulate a multi-sector dynamic model featuring capital and labour adjustment costs that we fit to Argentine data. Using counterfactual simulations of a tariff decline in the textile sector, we show that capital adjustment can create long-run responses of real wages that are larger than the short-run responses. This happens as textile firms disinvest during the transition. We also show that the reduction of tariffs on capital inputs boosts investment and real wages across sectors.
Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f
Authors: Siswanto Ferbian Milas , Sakuma Rika , Oguro Ami , Imaoka Susumu 
Published: March 2022

Abstract
Chlorogenic acid (CGA) is the most abundant polyphenol in coffee. It has been widely reported to exhibit antioxidant activity by activating nuclear factor erythroid 2-related factor 2 (Nrf2) potentially via the canonical Kelch-like-ECH-associated protein 1 (Keap1)-Nrf2 pathway. We herein demonstrated that the knockdown of WD40 repeat protein 23 (WDR23), but not Keap1, abolished the effects of CGA on the activation of Nrf2. CGA decreased the expression of DDB1, an adaptor for WDR23-Cullin 4A-RING ligase (CRL4AWDR23). FOXO3, a major target for inactivation by the PI3K/Akt pathway, was identified as the transcription factor responsible for the basal and CGA-inhibited expression of the DDB1 gene. CGA blocked FOXO3 binding to importin-7 (IPO7), thereby inhibiting the nuclear accumulation of FOXO3, down-regulating the expression of DDB1, inhibiting the activity of CRL4WDR23, and ultimately increasing that of Nrf2. This pathway was conserved in Caenorhabditis elegans, and CGA extended the lifespan partly through this pathway. We found that in C. elegans, the isoform DAF-16a, but not DAF-16f, regulated the expression levels of ddb-1 mRNA and SKN-1 protein. CGA prolonged the mean lifespan of DAF-16a- and DAF-16f-rescued worms by 24% and 9%, respectively, suggesting that both isoforms involve in lifespan-extending effects of CGA, with DAF-16a being more important than DAF-16f. Based on these results, we established a novel Akt-FOXO3/DAF16a-DDB1 axis that links nutrient sensing and oxidative stress response pathways. Our results also provide a novel molecular mechanism for Nrf2/SKN-1 activation by CGA and the increased lifespan of C. elegans by CGA via this pathway.
The Clinical Effectiveness of a Physiotherapy Delivered Physical and Psychological Group Intervention for Older Adults With Neurogenic Claudication: The BOOST Randomized Controlled Trial
Authors: Williamson Esther , Boniface Graham , Marian Ioana R , Dutton Susan J , Garrett Angela , Morris Alana , Hansen Zara , Ward Lesley , Nicolson Philippa J A , Rogers David , Barker Karen L , Fairbank Jeremy C , Fitch Judith , French David P , Comer Christine , Mallen Christian D , Lamb Sarah E ,   BOOST Research Group, Maredza Mandy , Petrou Stavros , Bruce Julie , Griffith Frances , Collins Gary , Hutchinson Charles , Gagen Richard , Slack Mandy , Conway Oliver , Fitch Judith , Turner Eileen , Arden John , Torgerson David , Sackley Catherine , McCabe Candy , Taylor Stephanie , Hewitt Catherine , Forster Anne , Bearne Lindsey , Watson Jim 
Published: March 2022

Abstract

Background
Neurogenic claudication (NC) is a debilitating spinal condition affecting older adults’ mobility and quality of life.

Methods
A randomized controlled trial of 438 participants evaluated the effectiveness of a physical and psychological group intervention (BOOST program) compared to physiotherapy assessment and tailored advice (best practice advice [BPA]) for older adults with NC. Participants were identified from spinal clinics (community and secondary care) and general practice records and randomized 2:1 to the BOOST program or BPA. The primary outcome was the Oswestry Disability Index (ODI) at 12 months. Data were also collected at 6 months. Other outcomes included ODI walking item, 6-minute walk test (6MWT), and falls. The primary analysis was intention-to-treat.

Results
The average age of participants was 74.9 years (standard deviation [SD] 6.0) and 57% (246/435) were female. There was no significant difference in ODI scores between treatment groups at 12 months (adjusted mean difference [MD]: −1.4 [95% confidence intervals (CI) −4.03, 1.17]), but, at 6 months, ODI scores favored the BOOST program (adjusted MD: −3.7 [95% CI −6.27, −1.06]). At 12 months, the BOOST program resulted in greater improvements in walking capacity (6MWT MD: 21.7m [95% CI 5.96, 37.38]) and ODI walking item (MD: −0.2 [95% CI −0.45, −0.01]) and reduced falls risk (odds ratio: 0.6 [95% CI 0.40, 0.98]) compared to BPA. No serious adverse events were related to either treatment.

Conclusions
The BOOST program substantially improved mobility for older adults with NC. Future iterations of the program will consider ways to improve long-term pain-related disability.
Clinical Trials Registration Number: ISRCTN12698674
Association of Indication for Hospitalization With Subsequent Amyloid Positron Emission Tomography and Magnetic Resonance Imaging Biomarkers
Authors: Sprung Juraj , Laporta Mariana L , Knopman David S , Petersen Ronald C , Mielke Michelle M , Jack Clifford R , Martin David P , Hanson Andrew C , Schroeder Darrell R , Schulte Phillip J , Przybelski Scott A , Valencia Morales Diana J , Weingarten Toby N , Vemuri Prashanthi , Warner David O 
Published: March 2022

AbstractBackgroundHospitalization in older age is associated with accelerated cognitive decline, typically preceded by neuropathologic changes. We assess the association between indication for hospitalization and brain neurodegeneration.MethodsIncluded were participants from the Mayo Clinic Study of Aging, a population-based longitudinal study, with ≥1 brain imaging available in those older than 60 years of age between 2004 and 2017. Primary analyses used linear mixed-effects models to assess association of hospitalization with changes in longitudinal trajectory of cortical thinning, amyloid accumulation, and white matter hyperintensities (WMH). Additional analyses were performed with imaging outcomes dichotomized (normal vs abnormal) using Cox proportional hazards regression.ResultsOf 2 480 participants, 1 966 had no hospitalization and 514 had ≥1 admission. Hospitalization was associated with accelerated cortical thinning (annual slope change −0.003 mm [95% confidence interval (CI) −0.005 to −0.001], p = .002), but not amyloid accumulation (0.003 [95% CI −0.001 to 0.006], p = .107), or WMH increase (0.011 cm3 [95% CI −0.001 to 0.023], p = .062). Interaction analyses assessing whether trajectory changes are dependent on admission type (medical vs surgical) found interactions for all outcomes. While surgical hospitalizations were not, medical hospitalizations were associated with accelerated cortical thinning (−0.004 mm [95% CI −0.008 to −0.001, p = .014); amyloid accumulation (0.010, [95% CI 0.002 to 0.017, p = .011), and WMH increase (0.035 cm3 [95% CI 0.012 to 0.058, p = .006). Hospitalization was not associated with developing abnormal cortical thinning (p = .407), amyloid accumulation (p = .596), or WMH/infarctions score (p = .565).ConclusionsMedical hospitalizations were associated with accelerated cortical thinning, amyloid accumulation, and WMH increases. These changes were modest and did not translate to increased risk for crossing the abnormality threshold.
Optimizing Translational Research for Exceptional Health and Life Span: A Systematic Narrative of Studies to Identify Translatable Therapeutic Target(s) for Exceptional Health Span in Humans
Authors: Raghavachari Nalini , Wilmot Beth , Dutta Chhanda 
Published: March 2022

AbstractBackgroundExceptional longevity as manifested by the lower incidence and delayed onset of age-related disabilities/diseases that include cardiovascular disease, Alzheimer’s disease, cancer is believed to be influenced by inherent protective molecular factors in exceptionally long-lived individuals. Unraveling these protective factors could lead to the discovery of therapeutic target(s) and interventions to promote healthy aging.MethodsIn this context, the National Institute on Aging has established a collection of translational longevity research projects (ie, the Long-Life Family Study, the Longevity Consortium, Longevity Genomics, and the Integrative Longevity Omics) which are generating large omics data sets spanning the human genome to phenome and have embarked on cross-species multiomic data analyses integrating human and nonhuman species that display wide variation in their life spans.ResultsIt is expected that these studies will discover key signaling pathways that influence exceptional health span and identify therapeutic targets for translation to enhance health and life span. Other efforts related to translational longevity research include the “Comprehensive Evaluation of Aging-Related Clinical Outcomes and Geroproteins study,” which focuses on potential effects in humans of polypeptides/proteins whose circulating levels change with age, and for which experimental evidence indicates reversal or acceleration of aging changes. The “Predictive Human Mechanistic Markers Network” is devoted to the development of predictive markers of aging, for target engagement when testing novel interventions for healthy aging.ConclusionWe describe here the significance, the unique study design, categories of data sets, analytical strategies, and a data portal to facilitate open science and sharing of resources from these longevity studies to identify and validate potential therapeutic targets for healthy aging.
Chromosome-level genome assembly, annotation, and phylogenomics of the gooseneck barnacle Pollicipes pollicipes
Authors: Bernot James P , Avdeyev Pavel , Zamyatin Anton , Dreyer Niklas , Alexeev Nikita , Pérez-Losada Marcos , Crandall Keith A 
Published: March 2022

Abstract

Background
The barnacles are a group of &gt;2,000 species that have fascinated biologists, including Darwin, for centuries. Their lifestyles are extremely diverse, from free-swimming larvae to sessile adults, and even root-like endoparasites. Barnacles also cause hundreds of millions of dollars of losses annually due to biofouling. However, genomic resources for crustaceans, and barnacles in particular, are lacking.

Results
Using 62× Pacific Biosciences coverage, 189× Illumina whole-genome sequencing coverage, 203× HiC coverage, and 69× CHi-C coverage, we produced a chromosome-level genome assembly of the gooseneck barnacle Pollicipes pollicipes. The P. pollicipes genome is 770 Mb long and its assembly is one of the most contiguous and complete crustacean genomes available, with a scaffold N50 of 47 Mb and 90.5% of the BUSCO Arthropoda gene set. Using the genome annotation produced here along with transcriptomes of 13 other barnacle species, we completed phylogenomic analyses on a nearly 2 million amino acid alignment. Contrary to previous studies, our phylogenies suggest that the Pollicipedomorpha is monophyletic and sister to the Balanomorpha, which alters our understanding of barnacle larval evolution and suggests homoplasy in a number of naupliar characters. We also compared transcriptomes of P. pollicipes nauplius larvae and adults and found that nearly one-half of the genes in the genome are differentially expressed, highlighting the vastly different transcriptomes of larvae and adult gooseneck barnacles. Annotation of the genes with KEGG and GO terms reveals that these stages exhibit many differences including cuticle binding, chitin binding, microtubule motor activity, and membrane adhesion.

Conclusion
This study provides high-quality genomic resources for a key group of crustaceans. This is especially valuable given the roles P. pollicipes plays in European fisheries, as a sentinel species for coastal ecosystems, and as a model for studying barnacle adhesion as well as its key position in the barnacle tree of life. A combination of genomic, phylogenetic, and transcriptomic analyses here provides valuable insights into the evolution and development of barnacles.
The crustal and uppermost mantle dynamics of the Tengchong–Baoshan region revealed by P-wave velocity and azimuthal anisotropic tomography
Authors: Shen Wenhao , Liu Shaolin , Yang Dinghui , Wang Wenshuai , Xu Xiwei , Yang Shuxin 
Published: March 2022

SUMMARY
The Tengchong–Baoshan region (TBR) is located at the margin of the southeastern Tibetan Plateau (SETP) and is subject to the complex interaction among multiple tectonic blocks. Therefore, the TBR is approximate for investigating the mechanism responsible for the interaction among the SETP and its surrounding blocks. Based on eikonal equation-based seismic tomography, we obtain high-resolution P-wave velocity and azimuthal anisotropy at depths of 0–40 km beneath the TBR. We discover a large magma reservoir (with horizontal scale of ∼50 km and vertical scale of ∼15 km) in the middle-lower crust beneath the Tengchong volcanic zone, which is directly fed by hot materials from the uppermost mantle. We also detect a shallow magma chamber in the uppermost crust above the large reservoir. These magma reservoirs at different depths constitute a multiscale magma system. Furthermore, we observe a low-velocity belt beneath the Weixi–Qiaohou–Weishan and Nantinghe faults and postulate that it corresponds to lower crustal flow and hot mantle upwelling. Additionally, we infer that two M &gt; 7.0 earthquakes that have occurred in Baoshan block nucleated in the transition zone between low- and high-velocity anomalies. Based on the azimuthal anisotropy tomography results, we consider that incoherent deformation in the crust causes the uneven accumulation of stress, which facilitated the occurrence of these two events. The 2021 Ms 6.4 Yangbi earthquake also occurred in the transition zone between low- and high-velocity anomalies. Based on the P-wave velocity tomography results, we suggest that hot material decreases the fault strength and leads to the instability of the fault.