bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using language models and ontology topology to perform semantic mapping of traits between biomedical datasets
Authors: Liu Yi , Elsworth Benjamin L , Gaunt Tom R 
Published: August 2022

AbstractMotivationHuman traits are typically represented in both the biomedical literature and large population studies as descriptive text strings. Whilst a number of ontologies exist, none of these perfectly represent the entire human phenome and exposome. Mapping trait names across large datasets is therefore time-consuming and challenging. Recent developments in language modelling have created new methods for semantic representation of words and phrases, and these methods offer new opportunities to map human trait names in the form of words and short phrases, both to ontologies and to each other. Here we present a comparison between a range of established and more recent language modelling approaches for the task of mapping trait names from UK Biobank to the Experimental Factor Ontology (EFO), and also explore how they compare to each other in direct trait-to-trait mapping.ResultsIn our analyses of 1191 traits from UK Biobank with manual EFO mappings, the BioSentVec model performed best at predicting these, matching 40.3% of the manual mappings correctly. The BlueBERT-EFO model (finetuned on EFO) performed nearly as well (38.8% of traits matching the manual mapping). In contrast, Levenshtein edit distance only mapped 22% of traits correctly. Pairwise mapping of traits to each other demonstrated that many of the models can accurately group similar traits based on their semantic similarity.Availability and ImplementationOur code is available at https://github.com/MRCIEU/vectology.
A minimum Bayes Factor based threshold for activation likelihood estimation
Authors: Costa Tommaso , Liloia Donato , Cauda Franco , Fox Peter , Mutta Francesca Dalla , Duca Sergio , Manuello Jordi 
Published: August 2022

AbstractActivation likelihood estimation (ALE) is among the most used algorithms to perform neuroimaging meta-analysis. Since its first implementation, several thresholding procedures had been proposed, all referred to the frequentist framework, returning a rejection criterion for the null hypothesis according to the critical p-value selected. However, this is not informative in terms of probabilities of the validity of the hypotheses. Here, we describe an innovative thresholding procedure based on the concept of minimum Bayes factor (mBF). The use of the Bayesian framework allows to consider different levels of probability, each of these being equally significant. In order to simplify the translation between the common ALE practice and the proposed approach, we analised six task-fMRI/VBM datasets and determined the mBF values equivalent to the currently recommended frequentist thresholds based on Family Wise Error (FWE). Sensitivity and robustness toward spurious findings were also analyzed. Results showed that the cutoff log10(mBF)=5 is equivalent to the FWE threshold, often referred as voxel-level threshold, while the cutoff log10(mBF)=2 is equivalent to the cluster-level FWE (c-FWE) threshold. However, only in the latter case voxels spatially far from the blobs of effect in the c-FWE ALE map survived. Therefore, when using the Bayesian thresholding the cutoff log10(mBF)=5 should be preferred. However, being in the Bayesian framework, lower values are all equally significant, while suggesting weaker level of force for that hypothesis. Hence, results obtained through less conservative thresholds can be legitimately discussed without losing statistical rigor. The proposed technique adds therefore a powerful tool to the human-brain-mapping field.
FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1
Authors: Jung Suna , Shah Sneha , Han Geongoo , Richter Joel D. 
Published: August 2022

AbstractFragile X Syndrome (FXS) is a neurodevelopmental disorder that is often modeled inFmr1knockout mice where the RNA binding protein FMRP is absent. Here we show that inFmr1-deficient mice, RNA mis-splicing occurs in several brain regions and peripheral tissues. To assess molecular mechanisms of splicing mis-regulation, we employed N2A cells depleted ofFmr1. In the absence of FMRP, RNA-specific exon skipping events are linked to the splicing factors hnRNPF, PTBP1, and MBNL1. FMRP regulates the translation ofMbnl1mRNA as well asMbnl1RNA auto-splicing. ElevatedMbnl1auto-splicing in FMRP-deficient cells results in the loss of a nuclear localization signal (NLS)-containing exon. This in turn alters the nucleus-to-cytoplasm ratio of MBNL1. This re-distribution of MBNL1 isoforms inFmr1-deficient cells could result in downstream splicing changes in other RNAs. Indeed, further investigation revealed that splicing distruptions resulting fromFmr1depletion could be rescued by overexpression of nuclear MBNL1. AlteredMbnl1auto-splicing also occurs in human FXS post-mortem brain. These data suggest that FMRP-controlled translation and RNA processing may cascade into a general dys-regulation of splicing inFmr1-deficient cells.
SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
Authors: Kotler Oron , Khrapunsky Yana , Shvartsman Arik , Dai Hui , Plant Leigh D. , Goldstein Steven A.N. , Fleidervish Ilya 
Published: August 2022

AbstractVoltage-gated sodium channels located in axon initial segments (AIS) trigger action potentials (AP) and play pivotal roles in the excitability of cortical pyramidal neurons. The differential electrophysiological properties and distributions of NaV1.2 and NaV1.6 channels lead to distinct contributions to AP initiation and backpropagation. While NaV1.6 at the distal AIS promotes AP initiation and forward propagation, NaV1.2 at the proximal AIS promotes backpropagation of APs to the soma. Here, we show the Small Ubiquitin-like Modifier (SUMO) pathway modulates persistent sodium current (INaP) generation at the AIS to increase neuronal gain and the speed of backpropagation. Since SUMO does not affect NaV1.6, these effects were attributed to SUMOylation of NaV1.2. Moreover, SUMO effects were absent in a mouse engineered to express NaV1.2-Lys38Gln channels that lack the site for SUMO linkage. Thus, SUMOylation of NaV1.2 exclusively controls INaP generation and AP backpropagation, thereby playing a prominent role in synaptic integration and plasticity.Significance StatementResolving a long-standing controversy, SUMOylation of NaV1.2 channels is revealed to regulate the excitability of cortical neurons by augmenting persistent sodium current at critical subthreshold voltages. SUMOylation increases the speed of action potential backpropagation from the axon initial segment to the soma, a phenomenon critical to long-term potentiation, spike-time dependent plasticity, and release of retrograde factors essential to synaptic plasticity and development.
Combining Sodium MRI, Proton MR Spectroscopic Imaging and Intracerebral EEG in Epilepsy
Authors: Azilinon Mikhael , Scholly Julia , Zaaraoui Wafaa , Villalon Samuel Medina , Viout Patrick , Roussel Tangi , El Mendili Mohamed Mounir , Ridley Ben , Ranjeva Jean-Philippe , Bartolomei Fabrice , Jirsa Viktor , Guye Maxime 
Published: August 2022

AbstractWhole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. In this study we combined sodium MRI (23Na MRI) and 1H-MR Spectroscopic Imaging (1H-MRSI) and compared ionic/metabolic changes probed by this multimodal approach to intracerebral stereotactic-EEG (SEEG) recordings.We applied a multi-echo density adapted 3D projection reconstruction pulse sequence at 7T (23Na MRI) and a 3D echo planar spectroscopic imaging sequence at 3T (1H-MRSI) in 19 patients suffering from drug-resistant focal epilepsy who underwent presurgical SEEG. We investigated 23Na MRI parameters including total sodium concentration (TSC) and the sodium signal fraction associated of with the short component of T2* decay (f), alongside the level of metabolites N-acetyl aspartate (NAA), choline compounds (Cho) and total creatine (tCr). All measures were extracted from spherical regions of interest (ROIs) centered between two adjacent SEEG electrode contacts and z-scored against the same ROI in controls.Group comparison showed a significant increase in f only in the epileptogenic zone (EZ) compared to controls and compared to patients propagation zone (PZ) and non-involved zone (NIZ). TSC was significantly increased in all patients’ regions compared to controls. Conversely, NAA levels were significantly lower in patients compared to controls, and lower in the EZ compared to PZ and NIZ. Multiple regression analyzing the relationship between sodium and metabolites levels revealed significant relations in PZ and in NIZ but not in EZ.Our results are in agreement with the energetic failure hypothesis in epileptic regions associated with widespread tissue reorganization.
Spatial-temporal dynamics and recurrence of chikungunya virus in Brazil
Authors: de Souza William M. , Lima Shirlene T. S. , Simões Mello Leda M. , Candido Darlan S. , Buss Lewis , Whittaker Charles , Claro Ingra M. , Chandradeva Nilani , Granja Fabiana , de Jesus Ronaldo , Lemos Poliana S. , Toledo-Teixeira Daniel A. , Barbosa Priscilla P. , Firmino Antonio Carlos L. , Amorim Mariene R. , Duarte Larissa M. F. , Pessoa Ivan B. , Forato Julia , Vasconcelos Irihane L. , Maximo Ana Carolina B. M. , Araújo Emerson L. L. , Perdigão Mello Liana , Sabino Ester C. , Proença-Módena José Luiz , Faria Nuno R. , Weaver. Scott C. 
Published: August 2022

AbstractChikungunya virus (CHIKV) is an Aedes mosquito-borne virus that has caused explosive epidemics linked to acute, chronic, and severe clinical outcomes. Since 2014, Brazil has had the highest number of chikungunya fever (CHIKF) cases in the Americas. Here, we report and contextualize the spatiotemporal dynamic of CHIKF in Brazil and combine genomic, epidemiological, and vector analyses to investigate CHIKF recurrence in several Brazilian states. From 2013 to 2022, CHIKV caused seven epidemic waves across Brazil, affecting 59.5% (3,316 of 5,570) of the country’s municipalities. To date, Ceará State in the northeast has been the most affected, with 81,274 cases during the two largest epidemic waves in 2016 and 2017, and the ongoing third wave in 2022. The 2022 CHIKF recurrence was associated with a new introduction of an East/Central/South African strain. Also, the CHIKV recurrences in Ceará, Tocantins, and Pernambuco States were limited to municipalities with few or no prior reported cases in the previous epidemic waves, suggesting that spatial heterogeneity of CHIKV spread and population immunity may explain the recurrence pattern in the country. In addition, the population density metrics of main CHIKV vector in Brazil, Ae. aegypti, were not correlated spatially with locations of CHIKF recurrence in Ceará and Tocantins States. Also, we show that CHIKF disproportionally affected females, and we estimated the case-fatality ratio in Ceará at ∼1.3 deaths per 1,000 cases. These findings more comprehensively describe CHIKV epidemics in Brazil and contribute to understanding CHIKF recurrence in urban settings. Overall, this information may help guide public health policy to mitigate and reduce the burden of urban arboviruses.
Consistency and applicability of return to activity guidelines in tactical-athletes with exertional heat illness. A systematic review
Authors: O’Reilly Matthew , Hu Yao-Wen Eliot , Gruber Jonathan , Jones Douglas M. , Daniel Arthur , Marra Janelle , Fraser John J. 
Published: August 2022

ABSTRACTObjectiveTo assess the consistency of return to sport and occupation recommendations following EHI provided in published clinical practice guidelines, consensus statements, position statements, and practice alerts. A secondary aim was to evaluate the consistency of medical policies governing the return to duty following EHI between the branches of the United States Armed Forces and the agreement with published recommendations.MethodsOvid MEDLINE, Web of Science, and CINAHL databases were searched for clinical practice guidelines and position statements published at any time that guided return to activity in individuals with EHI. Methodological quality was assessed and the specific recommendations for clinical management were extracted. Consistency of recommendations was evaluated.Agreement between published guidelines and the policies governing return to activity in military tactical athletes with heat injury were also evaluated.ResultsTwo professional societal guidelines provided recommendations pertaining to return to function following EHI. There was consistency between guidelines regarding recommendations that addressed abstinence from activity; medical follow-up; graded resumption of activity; and return to function. Pertaining to military policy, contemporary regulations published in recent years reflected the best evidence provided in the professional guidelines. The greatest incongruency was noted in older military policies.ConclusionsThis systematic review highlights the need for consistent recommendation across all branches of the military when it comes to returning servicemembers to duty after EHI.
Structural insights into ATP-sensitive potassium channel mechanics: a role of intrinsically disordered regions
Authors: Walczewska-Szewc Katarzyna , Nowak Wiesław 
Published: August 2022

AbstractCommonly used techniques, such as CryoEM or Xray, are not able to capture the structural reorganizations of disordered regions of proteins (IDR), therefore it is difficult to assess their functions in proteins based exclusively on experiments. To fill this gap, we used computational molecular dynamics simulations methods to capture IDR dynamics and trace biological function-related interactions in the Kir6.2/SUR1 potassium channel. This ATP-sensitive octameric complex, one of the critical elements in the insulin secretion process in human pancreatic β-cells, has four to five large, disordered fragments. Using unique MD simulations of the full Kir6.2/SUR1 channel complex, we present an in-depth analysis of the dynamics of the disordered regions and discuss the possible functions they could have in this system. Our MD results confirmed the crucial role of the N-terminus of the Kir6.2 fragment and the L0-loop of the SUR1 protein in the transfer of mechanical signals between domains that trigger insulin release. Moreover, we show that the presence of IDRs affects natural ligands binding. Our research takes us one step further towards understanding the action of this vital complex.
The fashion retailer's opportunity: effect of deal-seeking behavior on mobile shopping intention of showroomers
Authors: Chokkannan Pradeepkumar , Bhavani Shankar Saripalli , Pattusamy Murugan 
Published: August 2022

PurposeThis study aims to examine the positive impact of showrooming on the fashion retail business by examining the interrelationship between deal-seeking on mobile devices and digital coupon redemption intention on mobile shopping intention.Design/methodology/approachPurposive sampling was used to obtain data from 496 fashion apparel customers using the database of an online survey collection platform. Stimulus organism response (S-O-R) theory was used to examine the influence of showrooming on showroomers' mobile shopping intentions.FindingsThe findings suggest price consciousness is negatively related to showrooming and product involvement is positively related. In addition, showrooming affects the intention to redeem digital coupons and mobile deal-seeking. The intention to redeem digital coupons boosted mobile deal-seeking behavior. The impact of mobile deal-seeking on showroomers' mobile purchase intention is significant.Research limitations/implicationsThis research focused on fashion product consumers and generalization of the findings may be limited. The literature on positive effect of showrooming phenomenon on brick-and-mortar stores are scarce further extensive research may provide substantial generalization.Practical implicationsThis demonstrates how showroomers may be successfully enticed to make purchases on the Brick-and-Mortar (B&M) store's online channel.Originality/valueThis study provides insights on navigating the showroomers into online channel customers.
Has COVID-19 influenced the perceived quality of service of hotels?
Authors: Díaz-Santamaría Carlos , Bulchand-Gidumal Jacques , Melián-González Santiago 
Published: August 2022

Purpose
The purpose of this paper is to analyze the perceived quality of service by guests in the reopening process during the COVID-19 pandemic.

Design/methodology/approach
The authors analyzed 1,679 TripAdvisor reviews from 2019 and 2020 that were written for hotels in Gran Canaria, Spain. The authors compared the average rating for 2019 and 2020 and the authors performed a content analysis of the reviews.

Findings
Guests perceived the quality of their stay to be worse during 2020, especially regarding food and beverage and staff behavior. The only service quality dimension that showed an improvement was related to open-air hotel installations.

Research limitations/implications
The authors only analyzed reviews in one language. The authors were not able to determine if the lower ratings in 2020 were due to the way in which they perceived the quality of service or to the fact that the quality of service was objectively worse.

Originality/value
This paper contributes to theory development in the field of hospitality management by providing new insights into how external events can influence hotel services and guests’ perceptions. This research shows how a health crisis that is external to the tourism industry has caused an impact on hotel staff management and on how hotel staff behavior is perceived. However, it is also possible that regardless of anything managers do, the rating that a guest awards a hotel will be lower than it would have been before the pandemic.
Effect of network position on inter-team conflict and project success in megaprojects
Authors: Liu Cong , Cao Jiming , Duan Kaifeng , Wu Guangdong 
Published: August 2022

PurposeThis study investigates the impact of network positions on inter-team conflicts and project success in megaprojects.Design/methodology/approachNetwork position is measured with centrality and structural holes. Substantive conflict and affective conflict reflect inter-team conflicts. A questionnaire survey was implemented in Chinese megaprojects, and 309 valid questionnaires were collected. The data were analyzed using structural equation modeling and bootstrapping methods.FindingsThe results show that centrality negatively impacts project success, while the presence of a team in a structural hole has no significant impact on project success. Centrality is negatively related to substantive conflict and is positively related to affective conflict. The team in a structural hole has a positive effect on substantive conflict and a negative effect on affective conflict. Substantive conflict and affective conflict have positive and negative effects on project success, respectively. The effect of network position on project success is mediated by inter-team conflict.Research limitations/implicationsThis research provides a reference for megaproject managers to better conduct network governance, manage inter-team conflict, and successfully manage projects. The study did not investigate the effects of changes in teams' network positions on project success. Future research should explore this facet of megaprojects.Originality/valueThis research adds to existing research on network position, and reveals that project network governance is important for megaproject success. This provides a new direction for megaproject management. Furthermore, the results validate constructive and non-constructive roles and the mediating role of inter-team conflict. This complements the literature on conflict management, providing a reference for megaproject managers when managing inter-team conflict.
Ascertaining the place of UN sustainable development goals in public libraries: how much progress have public libraries made in Bangladesh?
Authors: Islam Md. Anwarul , Sultana Rafia , Widén Gunilla 
Published: August 2022

Purpose
This study aims to investigate the sustainable development goals (SDGs) awareness of public librarians, their perceived understanding of public libraries to achieve United Nation Sustainable Development Goals (UNSDGs) and identify the challenges affect the library adoption to SDGs.

Design/methodology/approach
In this study, a quantitative survey method was used to collect responses. The study population was all head of public libraries in Bangladesh. Seventy-one personalized individual e-mails with a link to a Web-based questionnaire were sent out to the public librarians (head of public libraries) inviting them to participate in this study. Fifty-nine responded to the survey, which was 83.09% of all population.

Findings
The findings revealed that public librarians working in different public libraries were generally aware of UNSDGs. The perceived understanding on the role of public libraries to achieve SDGs varies from SDG#1 to SDG1#7. However, most of the librarians’ responses ranked well in line with SDGs#1, #2, #3, #4 and #17, and they believed that their public libraries are doing well on some of these goals. Out of 17 SDGs, public libraries are working well on 7 goals. Lack of SDG-related activities, awareness, funds, implementation plan and unwillingness of the policymakers are challenges identified in this study.

Originality/value
There are not many studies on public libraries in Bangladesh, and the research areas are not diverse. There are only few studies in this area, and there is a need for different kinds of studies to reach a better overview and understanding when developing public library services to support SDGs. This could serve as the basis for a deeper study.
Barriers to the deployment of solar photovoltaic in public universities in South Africa: a Delphi study
Authors: Geh Nutifafa , Emuze Fidelis , Das Dillip Kumar 
Published: August 2022

PurposeThe deployment of solar photovoltaic (PV) in higher education institutions is beneficial and critical for attaining sustainable campus goals. However, various barriers hamper the adoption of the technology, and unless these challenges are identified, formulating tailor made solutions to boost deployment will be challenging. Thus, this study aimed to identify the barriers to the deployment of PV in the public university sector in South Africa.Design/methodology/approachA critical review of the literature was conducted to identify the factors that negatively impact PV deployment. By screening the barriers identified from the literature using a conceptual framework, the barriers that were considered relevant to deployment within a university context were selected. Thereafter, the selected barriers and additional barriers recommended by panellists were verified through a three-round Delphi survey. The factors were either accepted or rejected as barriers in the sector based on the factors' mean score and interquartile range values.FindingsThe study observed that 12 barriers hamper PV deployment in the public university sector. The findings indicated that the top five barriers were the lack of incentives, lack of green building targets, lack of financial resources, high initial cost, and lack of clear policy direction. However, the study found that deployment was not hindered because there was resistance to change or uncertainty of recouping investment costs. The deployment was also not hindered because there was a lack of demand from electricity end-users or a lack of suitable installation space.Originality/valueGiven the lack of empirical studies on the subject in the region, the present study contributes to the body of knowledge by identifying the significant barriers that impede PV deployment in the public university sector. Furthermore, insight is provided on measures that relevant stakeholders can take to motivate and support universities to deploy the technology further.