bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender differences in the correlation between body mass index and cognitive impairment among the community-dwelling oldest-old in China: a cross-sectional study
Authors: Chen Na , Cao JiaWei , Zhang Wei , Chen Yanan , Xu Ling 
Published: November 2022

ObjectiveThis study investigates gender differences in the correlation between body mass index (BMI) and cognitive impairment among Chinese community-dwelling oldest-old.SettingTwenty-three provinces in China. Participants’ mini-mental state examination (MMSE) scores <24 were considered cognitive impairment. Furthermore, the assessment standards of BMI status were classified into four categories: obese (BMI >30), overweight (25≤BMI≤30), normal (18.5≤BMI<25) and underweight (BMI <18.5).ParticipantsA total of 9218 older adults (age 80+) were included from the 2018 wave of Chinese Longitudinal Healthy Longevity Study.MethodsCognitive impairment, BMI and other covariates consisted of the sociodemographic variables, health behaviours and health status were collected. Cognitive impairment was assessed by the MMSE. Inverse probability weighting procedure was adopted to deal with bias due to dropout.Logistic regression was conducted to examine the correlation between BMI and cognitive impairment.ResultsAmong 9218 respondents, 3837 were males. Overall, the percentage of participants with cognitive impairment was 44.7%, with 32.1% among males and 53.7% among females. After controlling for other variables, males who were either overweight or underweight and females who were underweight were found to have higher risk of cognitive impairment among the oldest-old. Age, education, economic status, physical activity, activities of daily living, hypertension as well as heart disease were the predicting factors of cognitive impairment.ConclusionsThe relationship between BMI and cognitive impairment differs between male and female oldest-old, suggesting that we should pay attention to different BMI groups and adopt precise prevention strategies based on gender.
Todurujo na Kadurok (empowering youth): study protocol of an HIV self-testing and edutainment comic cluster randomised trial among refugee youth in a humanitarian setting in Uganda
Authors: Logie Carmen H , Okumu Moses , Loutet Miranda G , Coelho Madelaine , Berry Isha , Gittings Lesley , Odong Lukone Simon , Kisubi Nelson , Atama Malon , Kyambadde Peter 
Published: November 2022

IntroductionRefugees experience HIV vulnerabilities due to the confluence of displacement, violence and poverty. HIV self-testing, understudied with refugees, is a promising method to increase testing uptake, yet challenges remain with linkages to confirmatory testing following a positive HIV self-test. This study aims to evaluate the effectiveness of HIV self-testing kits and ‘edutainment’ comics in increasing HIV testing and HIV status knowledge among refugee youth aged 16–24 years in Bidi Bidi Refugee Settlement, Uganda.Methods and analysisThis study will be conducted in Bidi Bidi. We conducted a qualitative formative phase with focus groups (n=40) to generate knowledge of barriers and facilitators of HIV prevention, testing and care among refugee youth (aged 16–24) in Bidi Bidi. These findings were used to create comic scenarios aligning with edutainment approaches to health promotion and inform a four-arm cluster randomised controlled trial in Bidi Bidi using a 2×2 factorial design: (1) HIV self-testing alongside edutainment comics, (2) HIV self-testing alone, (3) edutainment comic alone and (4) standard of care. The target sample size will be 120 youth (30 per arm), who will be enrolled in the trial and followed for 3 months. Data will be collected at baseline and 3 months after enrolment. The primary outcomes (HIV testing frequency, HIV status knowledge) and secondary outcomes (linkage to confirmatory HIV testing, HIV care linkage, HIV self-test kit use, HIV-related stigma, HIV knowledge, safer sex efficacy, condom use, adolescent sexual and reproductive health (SRH) stigma, sexual relationship power, access to SRH services) will be evaluated using descriptive statistics and regression analyses.Ethics and disseminationThis study was approved by the University of Toronto Research Ethics Board, Mildmay Uganda Research Ethics Committee and the Uganda National Council for Science and Technology. Results will be shared in peer-reviewed publications and community knowledge sharing.Trial registration numberNCT05213689.
Systematic literature review of adopting eHealth in pharmaceutical care during COVID-19 pandemic: recommendations for strengthening pharmacy services
Authors: Cen Zhi Feng , Tang Pou Kuan , Hu Hao , Cavaco Afonso , Zeng Luoxin , Lei Sut Leng , Ung Carolina Oi Lam 
Published: November 2022

ObjectivesThe study aimed to determine how eHealth was adopted in pharmaceutical care (PC), the outcome reported and the contextual factors.DesignSystematic literature review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesLiterature was searched in six databases including PubMed, Scopus, Medline, Web of Science, Science Direct and China National Knowledge Infrastructure.Eligibility criteriaStudies which reported the usage experiences of eHealth in any aspects of PC by pharmacists during the COVID-19 pandemic, written in English or Chinese, and published in peer-reviewed journals between December 2019 and March 2022 were included. Opinion articles, conference abstracts, correspondence, letters and editorials were excluded.Data extraction and synthesisThe literature search was completed on 15 April 2022. Two researchers independently conducted the literature search and extracted the data into an Excel table informed by the logic model with the key components of goals, input, activities, output and contextual factors.ResultsForty-three studies were included in this review. During the COVID-19 pandemic, hospital pharmacists, community pharmacists and specialist pharmacists in 17 countries continued to educate, consult, monitor and manage the patients and the general public via phone calls, videoconferences, mobile applications, social media, websites and/or enhanced interoperability of electronic medical records. Assuring the continuity of pharmacy care, reduced need for hospital visits, and improved work accuracy and efficiency were the benefits of eHealth mostly reported. Contextual factors affecting the adoption of eHealth were multifaceted, prompting supporting actions at the levels of government, hospital/pharmacy, pharmacists and patients.ConclusionThis study revealed the wide adoption of eHealth in PC during the pandemic and the emerging evidence for its importance. Proper adoption of eHealth will help reshape the mode of pharmacy services to ensure continuity, quality and efficiency of care amid the challenges of the pandemic.PROSPERO registration numberCRD42022299812.
Clinically assisted hydration in patients in the last days of life (‘CHELsea II’ trial): a cluster randomised trial
Authors: Davies Andrew , Waghorn Melanie , Roberts Megan , Gage Heather , Skene Simon S 
Published: November 2022

IntroductionProvision of clinically assisted hydration (CAH) at the end of life is one of the most contentious issues in medicine. The aim of the ‘CHELsea II’ trial is to evaluate CAH in patients in the last days of life. The objectives are to assess the effect of CAH on delirium, audible upper airway secretions, pain and other symptoms, and overall survival, as well as the tolerability of CAH, and the health economic impact.Methods and analysisThe study is a cluster randomised trial, involving 80 sites/clusters (mainly hospices) and 1600 patients. Sites will be randomised to an intervention, and this will become the standard of care during the trial. Intervention ‘A’ involves continuance of drinking (if appropriate), mouth care and usual end-of-life care. Intervention ‘B’ involves continuance of drinking, mouth care, usual end-of-life care and CAH, that is, parenteral fluids. The fluid may be given intravenously or subcutaneously, the type will be dextrose saline (4% dextrose, 0.18% sodium chloride) and the volume will be dependent on weight.Participants will be assessed every 4 hours by the clinical team. The primary endpoint is the proportion of participants who develop delirium determined using the Nursing Delirium Screening Scale (using a cut-off score of ≥2). A mixed-effects logistic regression will be used to assess the difference in the odds of developing delirium between the interventions.Ethics and disseminationEthical committee approval has been granted by the Brighton and Sussex Research Ethics Committee (REC) (main REC for the UK: reference—IRAS 313640), and by the Scotland A REC (REC for adults with incapacity in Scotland: reference—22/SS/0053-IRAS-317637). The consent process follows the Mental Capacity Act: if the patient has capacity, then consent will be sought in the normal way; if the patient does not have capacity, then a personal/nominated consultee will be approached for advice about the patient entering the study. The consent process is slightly different in Scotland.The results of the trial will be published in general medical/palliative care journals, and presented at general medical/palliative care conferences.Trial registration numberISRCTN65858561.
Characterisation of the safety profile of evobrutinib in over 1000 patients from phase II clinical trials in multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus: an integrated safety analysis
Authors: Montalban Xavier , Wallace Daniel , Genovese Mark C , Tomic Davorka , Parsons-Rich Dana , Le Bolay Claire , Kao Amy H , Guehring Hans 
Published: November 2022

ObjectiveAnalyse the integrated safety profile of evobrutinib, a Bruton’s tyrosine kinase inhibitor (BTKi), using pooled data from multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) trials.MethodsPhase II, randomised, double-blind, placebo-controlled trial data were analysed (N=1083; MS: n=213, 48 weeks (W); RA: n=390, 12W; SLE: n=480, 52W). The analysis included all patients who received ≥1 dose of evobrutinib (25 mg or 75 mg once daily, or 50 mg or 75 mgtwice daily) or placebo. Descriptive statistics and exposure-adjusted incidence rates (EAIR) were used to report treatment-emergent adverse events (TEAEs).ResultsData from 1083 patients were pooled: evobrutinib, n=861; placebo, n=271 (sum >1083 due to MS trial design: n=49 received both placebo (W0–24) and evobrutinib 25 mg (W25–48)); median follow-up time (pt-years): evobrutinib, 0.501; placebo, 0.463. Across indications, the proportion of patients with TEAEs and the EAIR were similar for evobrutinib and placebo (66.2% (247.6 events/100 pt-years) vs 62.4% (261.4 events/100 pt-years)). By indication, the EAIR (events/100 pt-years) of TEAEs for evobrutinib versus placebo were: MS: 119.7 vs 148.3; RA: 331.8 vs 306.8; SLE: 343.0 vs 302.1. Two fatal events occurred (in SLE). The serious infections EAIR was 2.7 and 2.1 events/100 pt-years for evobrutinib and placebo. For previously reported BTKi-class effects, the EAIR of transient elevated alanine aminotransferase/aspartate aminotransferase TEAEs (events/100 pt-years) with evobrutinib versus placebo was 4.8 vs 2.8/3.5 vs 0.7, respectively. IgG levels were similar in evobrutinib/placebo-treated patients.ConclusionsThis is the first BTKi-integrated safety analysis that includes patients with MS. Overall, evobrutinib treatment (all doses) was generally well tolerated across indications.Trial registration numbersNCT02975349,NCT03233230,NCT02975336.
The role of hyperbaric oxygen therapy in the management of perioperative peripheral nerve injury: a scoping review of the literature
Authors: Brenna Connor TA , Khan Shawn , Katznelson Rita , Brull Richard 
Published: November 2022

Background/importancePeripheral nerve injury is an uncommon but potentially catastrophic complication of anesthesia and surgery, for which there are limited effective treatment options. Hyperbaric oxygen therapy is a unique medical intervention which improves tissue oxygen delivery and reduces ischemia via exposure to oxygen at supra-atmospheric partial pressures. While the application of hyperbaric oxygen therapy has been evidenced for other medical conditions involving relative tissue ischemia, its role in the management of peripheral nerve injury remains unclear.ObjectiveThis scoping review seeks to characterize rehabilitative outcomes when hyperbaric oxygen therapy is applied as an adjunct therapy in the treatment of perioperative peripheral nerve injury.Evidence reviewThe review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines for scoping reviews, using a systematic screening and extraction process. The search included articles published from database inception until June 11, 2022, which reported clinical outcomes (in both human and non-human models) of peripheral nerve injury treated with hyperbaric oxygen therapy.FindingsA total of 51 studies were included in the narrative synthesis. These consisted of animal (40) and human studies (11) treating peripheral nerve injury due to various physiological insults. Hyperbaric oxygen therapy protocols were highly heterogenous and applied at both early and late intervals relative to the time of peripheral nerve injury. Overall, hyperbaric oxygen therapy was reported as beneficial in 88% (45/51) of included studies (82% of human studies and 90% of animal studies), improving nerve regeneration and/or time to recovery with no reported major adverse events.ConclusionsExisting data suggest that hyperbaric oxygen therapy is a promising intervention in the management of perioperative peripheral nerve injury, in which tissue ischemia is the most common underlying mechanism of injury, neurological deficits are severe, and treatment options are sparse. This positive signal should be further investigated in prospective randomized clinical trials.
Eimeria infection-related intestinal dynamics and microbiome, growth performance, and nutrient utilization in broiler chickens fed diets supplemented with multienzyme
Authors: Yuan Jing , Johnson Timothy A. , Ajuwon Kolapo M. , Adeola Olayiwola 
Published: November 2022

Coccidiosis is an infectious parasitic disease. Increasing drug resistance and variable vaccine effectiveness have stimulated interests in developing alternate control strategies. Our research studied the effects of dietary supplementation of multienzyme (phytase, xylanase, β-glucanase, amylase, hemicellulase, and pectinase) in broiler chickens infected with coccidial pathogens by assessing ( i) nutrient utilization, immunological response, and gut health-related indicators in small intestine; and ( ii) intestinal microbiome modulations. One-day-old male Ross 708 chicks were assigned to 4 treatments in a 2 × 2 factorial arrangement comprising of 0 or 50 g·kg−1 multienzyme and oral challenge with phosphate buffer saline or mixed Eimeria spp. oocysts (250 000 E. acervulina, 50 000 E. maxima, and 50 000 E. tenella). Multienzyme reduced ( P < 0.05) Eimeria-induced loss in feed efficiency and nutrient utilization, partially explained by reduced decrease of b0,+ amino acid transporter in jejunum. Multienzyme suppressed ( P < 0.05) the overexpression of interleukin-8 in duodenum and jejunum and ameliorated ( P = 0.05) the decreased expression of antioxidant heme oxygenase 1 in ileum induced by Eimeria infection. Multienzyme facilitated ( P < 0.01) the bloom of short-chain fatty acid-producing and fiber-degrading microbes. Multienzyme supplementation partly mitigated the adverse effects of Eimeria infection through multiple mechanisms: improving nutrient utilization, reducing local inflammation, and restoring microbial homeostasis.
Structural core observations in a siliciclastic reservoir-scale framework
Authors: Fossen Haakon 
Published: November 2022

Abstract
Detailed knowledge of subseismic structures and their influence on reservoir production performance is important for optimal reservoir management. Predicting subseismic structures from seismic-scale structural interpretations is inherently difficult without the use of core data. Cores allow direct measurements of porosity and permeability of deformed rocks and enable researchers to make detailed investigation of deformation mechanisms and cementation processes. Frequency, distribution and sometimes orientation of planar structures can be constrained. Such observations are then used together with location relative to seismically mapped fault and fold structures, and with respect to lithology and stratigraphy. However, a significant gap exists between the scale of core observation and the size of structures mappable from seismic data. Bridging this gap requires a sound general understanding of the different structures that occur in reservoirs, which, in addition to faults, includes drag folds, veins, fractures and the many types of deformation bands that can exist in porous rocks. Proper understanding of such subseismic structures is primarily based on outcrop-based observations and analyses, aided by physical experiments and numerical modelling. We stress that integrating such cutting-edge knowledge with core, seismic and other case-specific subsurface data in an appropriate tectonic context is paramount for realistic reservoir characterization and successful reservoir management.
DPIVE: A Regionalized Location Obfuscation Scheme with Personalized Privacy Levels
Authors: Zhang Shun , Lan Pengfei , Duan Benfei , Chen Zhili , Zhong Hong , Xiong Neal N. 
Published: November 2022

The popularity of cyber-physical systems is fueling the rapid growth of location-based services. This poses the risk of location privacy disclosure. Effective privacy preservation is foremost for various mobile applications. Recently, geo-indistinguishability and expected inference error are proposed for limiting location leakages. In this article, we argue that personalization means regionalization for geo-indistinguishability, and we propose a regionalized location obfuscation mechanism called DPIVE with personalized utility sensitivities. This substantially corrects the differential and distortion privacy problem of the PIVE framework proposed by Yu et al. on NDSS 2017. We develop DPIVE with two phases. In Phase I, we determine disjoint sets by partitioning all possible positions such that different locations in the same set share the Protection Location Set (PLS). In Phase II, we construct a probability distribution matrix in which the rows corresponding to the same PLS have their own sensitivity of utility (PLS diameter). Moreover, by designing a QK-means algorithm for more search space in 2-D space, we improve DPIVE with a refined location partition and present fine-grained personalization, enabling each location to have its own privacy level endowed with a customized privacy budget. Experiments with two public datasets demonstrate that our mechanisms have the superior performance, typically on skewed locations.
Semantic Completion and Filtration for Image–Text Retrieval
Authors: Yang Song , Li Qiang , Li Wenhui , Li Xuan-Ya , Jin Ran , Lv Bo , Wang Rui , Liu Anan 
Published: November 2022

Image–text retrieval is a vital task in computer vision and has received growing attention, since it connects cross-modality data. It comes with the critical challenges of learning unified representations and eliminating the large gap between visual and textual domains. Over the past few decades, although many works have made significant progress in image–text retrieval, they are still confronted with the challenge of incomplete text descriptions of images, i.e., how to fully learn the correlations between relevant region–word pairs with semantic diversity. In this article, we propose a novel semantic completion and filtration (SCAF) method to alleviate the above issue. Specifically, the text semantic completion module is presented to generate a complete semantic description of an image using multi-view text descriptions, guiding the model to explore the correlations of relevant region–word pairs fully. Meanwhile, the adaptive structural semantic matching module is presented to filter irrelevant region–word pairs by considering the relevance score of each region–word pair, which facilitates the model to focus on learning the relevance of matching pairs. Extensive experiments show that our SCAF outperforms the existing methods on Flickr30K and MSCOCO datasets, which demonstrates the superiority of our proposed method.
(Digital Presentation) The Role of Mg in Cut-Edge Corrosion Protection of 55 Mass% Al-Zn-Mg Coated Steel Under a Wet-Dry Cyclic Condition
Authors: Sugawara Yu , Ebina Ko , Suga Takumi , Fujii Takashi , Ueda Kohei 
Published: November 2022

Pre-painted hot-dip 55 mass% Al-Zn coated steel sheets are widely used as a building material due to their superior corrosion resistance. In consideration of its long-term service, a pre-painted hot-dip 55 mass% Al-Zn-2 mass% Mg coated steel sheet with enhanced corrosion resistance has been developed in recent years.1 It has been shown that the addition of 2 mass% Mg not only reduced the corrosion rate by 1/3 but also inhibited the delamination of organic paints from the cut-edge. As yet, however, the role of Mg in the cut-edge corrosion protection of the 55 mass% Al-Zn-2 mass% Mg coated steel has not been completely clear. In this study, we focused on the influence of Mg-containing corrosion products on the electrochemical properties of the coating layer and the steel substrate.
Hot-dip 55 mass% Al-Zn-2 mass% Mg-1.6 mass% Si and 55 mass% Al-Zn-1.6 mass% Si coated steel sheets were used in this study. The Al-Zn-Mg coating layer is composed of Al-rich, Zn-rich, and Mg-Si phases. Our previous study has reported that for the Al-Zn-Mg coating layer, the Zn-rich phase preferentially dissolves during the initial process of cut-edge corrosion.2 In addition, Mg also preferentially dissolves from the Mg-Si phase in the Al-Zn-Mg coating layer.
The wet and dry cyclic corrosion test showed that the formation of the Zn-based corrosion products at the cut-edge for the Al-Zn-Mg coated steel was more inhibited than that for the Al-Zn coated steel. In addition, the sacrificial corrosion protection ability of the Al-Zn-Mg coated steel was higher than the Al-Zn coated steel. It was found that the dense corrosion products including Mg were formed on the steel substrate at the cut-edge for the Al-Zn-Mg coated steel 1 hour after the onset of the corrosion test. The Mg-containing corrosion products slightly reduced the cathodic current for the oxygen reduction reaction, and this is thought to be one of the factors for the improved cut-edge corrosion resistance.
1) N. Shimoda, Y. Morimoto, Y. Kubo, S. Fujii, and S. Shiragaki, Galvatech 2015 Proceedings, 802 (2015).
2) S. Tokuda, I. Muto, Y. Sugawara, M. Takahashi, M Matsumoto, and N. Hara, Corros. Sci, 129, 126 (2017).