bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of MEDAG and SERPINE1 Related to Hypoxia in Abdominal Aortic Aneurysm Based on Weighted Gene Coexpression Network Analysis
Authors: Teng Biyun , Xie Chaozheng , Zhao Yu , Zeng Qiu , Zhan Fangbiao , Feng Yangyang , Wang Zhe 
Published: July 2022

Purpose: Abdominal aortic aneurysm (AAA) is a severe cardiovascular disease that often results in high mortality due to sudden rupture. This paper aims to explore potential molecular mechanisms and effective targeted therapies to prevent and delay AAA rupture.Methods: We downloaded two microarray datasets (GSE98278 and GSE17901) from the Gene Expression Omnibus (GEO) database. Differential analysis and single-sample gene set enrichment analysis (ssGSEA) of hypoxia scores were performed on 48 AAA patients in GSE98278. We identified hypoxia- and ruptured AAA-related gene modules using weighted gene coexpression network analysis (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed using the R package clusterProfiler. For candidate genes, validation was conducted on the mouse dataset GSE17901. Finally, we predicted drug candidates associated with the hub genes using the HERB Chinese medicine database.Results: Eighty-two differentially expressed genes were screened in the ruptured and stable groups; 103 differentially expressed genes were identified between the high- and low-hypoxia groups; and WGCNA identified 58 differentially expressed genes. Finally, nine candidate genes were screened, including two hub genes (MEDAG and SERPINE1). We identified pathways such as cytokine–cytokine receptor interaction and T-helper 1-type immune response involved in AAA hypoxia and rupture. We predicted 93 traditional Chinese medicines (TCMs) associated with MEDAG and SERPINE1.Conclusion: We identified the hypoxic molecules MEDAG and SERPINE1 associated with AAA rupture. Our study provides an additional direction for the association between hypoxia and AAA rupture.
Help-Seeking Behaviors and Related Factors in Chinese Patients With Major Depressive Disorder: A Community-Based Cross-Sectional Study
Authors: Cui Xiaojuan , Li Minghui , Li Peijun , Li Jinhao , Hou Xiaofei , Yan Guoli , Li Peiyao , Su Xuyang , Qin Danni , Zhang Yijiao , Gu Yan , Yin Huifang , Xu Guangming 
Published: July 2022

BackgroundAlthough evidence-based and effective treatments are available for people with major depressive disorder (MDD), a substantial number do not seek or receive help. Therefore, this study aimed to (1) investigate the total help-seeking rate and first-time help-seeking choices; (2) explore the perceived helpfulness of 23 potential sources; and (3) evaluate the factors related to help-seeking behaviors among patients with MDD.Materials and MethodsData came from the Tianjin Mental Health Survey (TJMHS), which included a representative sample of adult community residents (n = 11,748) in the Chinese municipality of Tianjin. Of these, 439 individuals were diagnosed with lifetime MDD according to the Diagnostic and Statistical Manual-fourth edition (DSM-IV) and administered a help-seeking questionnaire.ResultsIn a survey, 28.2% of patients with MDD living community reported that they had ever sought any help during their entire lifetime before the interview, with 8.2% seeking help in mental healthcare settings, 8.0% only in other healthcare settings, and 12.0% only in non-healthcare sources (e.g., family, friends, and spiritual advisor). Among help-seekers, the first help mainly was sought in non-healthcare sources (61.3%), followed by healthcare settings (25.8%) and mental healthcare settings (12.9%). The majority of MDD individuals thought the non-healthcare sources were not helpful and mental healthcare settings were helpful or possibly helpful to solve mental problems. Female, having 10–12 or higher education years, comorbid anxiety disorders were associated with increased help-seeking.ConclusionA small percentage of individuals with MDD living in community of Tianjin sought help. They preferred non-healthcare sources to healthcare settings. Demographic and clinical features were associated with help-seeking behaviors.
Poor Physical Capacity Combined With High Body Fat Percentage as an Independent Risk Factor for Incident Hypertension in Chinese Suburb-Dwelling Older Adults
Authors: Han Peipei , Zhang Yuanyuan , Chen Xiaoyu , Liang Zhenwen , Yu Xing , Liu Yuewen , Sang Sijia , Mao Jiayin , Liu Jingxuan , Chen Wuxiong , Li Junxue , Cheng Yazhou , Zheng Yaqing , Zhang Ziwei , Li Ming , Guo Qi 
Published: July 2022

BackgroundThis study examined the effects of poor physical capacity and high body fat percentage (BF%) on the incidence of hypertension in Chinese suburb-dwelling older adults.MethodsThis study was conducted on 368 Chinese suburb-dwelling participants aged ≥ 60 years without hypertension (mean age: 66.74 ± 5.59 years, 48.9% men). Poor physical capacity is defined by the Asian Working Group for Sarcopenia (AWGS) criteria as grip strength &lt; 26 kg for men and &lt; 18 kg for women or walking speed &lt;0.8 m/s. High BF% was defined as values that are greater than the upper tertile for BF% as stratified by sex. The outcome was the incidence of hypertension.ResultsOverall, 5.7% of subjects had both poor physical capacity and high BF%. After the average follow-up duration of 2 years, the incidence of hypertension was 39.7%, and those experiencing both poor physical capacity and high BF% had the highest incidence (81.0%). After multivariate adjustments, the incidence of hypertension was associated with the combination of poor physical capacity and high BF% [odds ratio (OR) = 6.43, 95% CI = 1.91–21.64] but not solely with poor physical capacity (OR = 1.11, 95% CI = 0.55–2.25) or only high BF% (OR = 1.37, 95% CI = 0.80–2.34).ConclusionThe combination of poor physical capacity and high BF% can significantly increase the incidence of hypertension in Chinese suburb-dwelling older adults. For hypertension prevention, ideally, we should strive toward decreasing body fat mass while simultaneously improving physical capacity.
The Impact of the COVID-19 Pandemic on the Lives of People With Gender Dysphoria
Authors: Guadagnin Fernanda , da Silva Dhiordan Cardoso , Schwarz Karine , Villas Bôas Anna Paula , Lobato Maria Inês Rodrigues 
Published: July 2022

ObjectiveTo analyze the impact on the psychological and social aspects caused by the COVID-19 pandemic in individuals diagnosed with Gender Dysphoria (GD).MethodsGoogle Forms inventory was sent via WhatsApp, including qualitative and quantitative questions evaluating three life dimensions denominated as Sociodemographic, Economic, and COVID-19 pandemic. It was applied in two periods: At the beginning of the pandemic (June-2020) (P1) and one year later (June-2021) (P2). The inventory also included questions about economic dimensions before the pandemic for individual comparison purposes (P0). 48 individuals (28 transsexual women, 20 transsexual men) participated in both periods.Results77.1% (n = 37) lived in Rio Grande do Sul, 50.0% (n = 24) refereed incomplete high school; Monthly Income increased significantly between the periods (P0) and (P1). Emergence aid approval was significantly higher in (P2), 56.3% (n = 27), compared to (P1), 39.6% (n = 19). A statistically significant difference was detected in the feeling of depression in the (P2) among the cases that requested Emergency Aid.ConclusionThe studied population presented deterioration regarding their condition of social vulnerability in relation to formal employment, access to health services, and mental health.
Telemedicine Is Becoming an Increasingly Popular Way to Resolve the Unequal Distribution of Healthcare Resources: Evidence From China
Authors: Gao Jinghong , Fan Chaolin , Chen Baozhan , Fan Zhaohan , Li Lifeng , Wang Linlin , Ma Qianqian , He Xianying , Zhai Yunkai , Zhao Jie 
Published: July 2022

BackgroundFew studies focused on the general situation of telemedicine in China.ObjectivesThe purpose of this review is to investigate telemedicine in China, from the aspects of necessity, history, scale, and operation procedure, to improve the further development and implementation of telemedicine service.MethodsA literature search for peer-reviewed studies was conducted using the primary electronic databases. Additional documents from the official websites of Chinese government departments involved telemedicine was also collected. We extracted telemedicine related information focused on China from the final retrieved materials, and the general situation of telemedicine was drawn.ResultsIn China, telemedicine offers a feasible solution to the unequal allocation of healthcare resources, which makes telemedicine increasingly become an important alternative to close the gap between rural and urban in the capability and quality of medical services. China initiated telemedicine in the late 1980s. In 2018, China's telemedicine network has covered more than 3,000 hospitals across the country. As of 2019, almost all of the 31 provinces and municipalities in mainland have established regional telemedicine centers, and the market size of telemedicine reached about USD 2.68 billion. Based on the telemedicine network, remote rural patients can apply for healthcare services of top-tier urban hospitals through local county-level medical institutions.ConclusionsThrough improving the capacity, quality, and efficiency of healthcare in underserved areas, and reducing the unequal distribution of medical resources, telemedicine can help solve the problems of the difficulty and high cost to access to medical services in China.
Practicing COVID-19 Public Health Measures Is Associated With Anxiety and Depression in Undergraduate University Students
Authors: Holladay Kelley , Lardier David , Amorim Fabiano T. , Zuhl Micah , Coakley Kathryn E. 
Published: July 2022

BackgroundCOVID-19 has affected mental health globally, increasing depression and anxiety. This study examined relationships between practicing COVID-19-related public health measures and depression and anxiety in young adult students.MethodsA sample of 755 undergraduate students 18–25 years of age at a large public university completed a cross-sectional survey in fall 2020 during the pandemic (response rate = 18.9%). The survey included demographic questions, anxiety and depression screeners (GAD-7 and PHQ-9), and questions on practicing public health measures (stay-at-home orders, quarantining, social distancing, etc.) since March 2020. Multivariate logistic regression was utilized to calculated adjusted odds between practicing public health measures and anxiety and depression.ResultsThe majority of respondents reported practicing public health measures; however, 53% experienced anxiety (GAD-7 score &gt;10) and 57% experienced depression (PHQ-9 score &gt;10) in the 2 weeks prior to completing the survey. Participants who quarantined had significantly higher odds of anxiety (AOR = 1.44; 95% CL 1.07, 1.96) and depression (AOR = 1.77; 95% CL 1.30, 2.41) than those who did not. Participants who self-isolated also had significantly higher odds of anxiety (AOR = 1.53; 95% CL 1.13, 2.08) and depression (AOR = 1.87; 95% CL 1.37, 2.56) compared to those who did not. Moving/changing living situations in response to the pandemic also increased odds of depression (AOR = 1.86; 95% CL 1.33, 2.60).ConclusionYoung adult undergraduate students experienced a high prevalence of anxiety and depression. Quarantining, self-isolating, and moving/changing living situations increased odds of anxiety and/or depression. The public health measures necessary for COVID-19 control and prevention may adversely affect mental health.
Seroprevalence and Risk Factors Associated with Toxoplasma gondii and Chlamydophila abortus Infection in Domestic Small Ruminants in Cameroon
Authors: Nankam Roland Chimi , Kouamo Justin , Kouengoua Armelle Prudence Kouengoua , Tchinze Grace Jedida Toukem , Dzousse Müller Fotsac , Gapgueu Sandra Vanessa , Guefack Noumedem Ranyl Nguena , Ngoula Ferdinand 
Published: July 2022

Toxoplasmosis and chlamydiosis remain among the primary causes of abortion and fetal loss in small ruminants. Consequently, they are a source of considerable economic losses for farmers. The objectives of this study were to determine the seroprevalence and highlight the risk factors associated with Toxoplasma gondii and Chlamydophila abortus infection in small ruminants in Cameroon. A cross-sectional study was conducted in 200 small ruminant farms during a period from April to October 2021. A total of 1061 small ruminants were sampled, and the sera obtained were analyzed using the indirect ruminant multi-species ELISA test for specific IgG antibody detection for T. gondii and C. abortus at the National Veterinary Laboratory. A questionnaire was constructed to collect information about flock management and risk factors possibly associated with T. gondii and C. abortus infection in goats and sheep. Overall, 329 small ruminants tested positive for T. gondii-specific IgG antibodies and 45 for C. abortus-specific IgG antibodies with a seroprevalence of 31.1% (95% CI: 28.2–33.8) for T. gondii and 4.2% (95% CI: 3.0–5.5) for C. abortus, respectively. However, a significant co-infection of 1.8% (95% CI: 0.37–3.3) was obtained between T. gondii and C. abortus (p = 0.02). Linear regression model analysis revealed that, the seroprevalence of T. gondii at the flock level was significantly correlated with the region (0.22 CI: 0.17; 0.26) the breeding objectives (0.36 CI: 0.17; 0.56) the level of hygiene (0.11 CI: 0.01; 0.21) and presence abortions (0.55 CI: 0.46; 0.64) on the farms and that of C. abortus was significantly correlated with the regions (0.01 CI: 0.00–0.02) and degree of abortion on the farms (−0.26 CI: −039; −0.14). At the individual level, a significant correlation was observed between the seroprevalence of T. gondii and region (−0.09 CI: −0.14; −0.04), species (0.07 CI: 0.01–0.14), sex (−0.11 CI: −0.18; −0.03), age (0.08 CI: 0.04–0.12) and physiological status (0.21 CI: 0.18; 0.24). For C. abortus seroprevalence, a significant correlation was observed with the regions (0.02 CI: 0.00; 0.03) and breed (0.01 CI: 0.01; 0.02) of small ruminants reared in the northern regions of Cameroon. These results could be used to implement efficient management measures to prevent and control T. gondii and C. abortus infection in goats and sheep in Cameroon.
Polynomial Approximation of Power System Eigenvalues for Fast Small Signal Stability Analysis
Authors: Khodaei Farhad 
Published: July 2022

<p>In power system dynamic analysis, computation of eigenvalues of state equations for various active dispatched powers is important. This concept provides a better understanding of the system dynamic behavior. In this paper, an approximate equation extraction technique is proposed for fast computation of real-part of the most critical eigenvalue of New England 39-bus power system. Simulation by using MATLAB PSAT toolbox is carried out as a source of the initial data for finding a proper approximate function and also its verification. As an application example, the obtained polynomial approximate function has been applied to small signal stability constrained optimal power flow by using GAMS optimization package. The obtained polynomial function can be used with various optimization criteria in the valid interval of the approximation. Also this polynomial function can be re-used when generation cost functions are changed, without need for a new dynamic analysis. All of the dynamic analyses by PSAT toolbox are performed by using automatic intermediate codes cooperating with functions and variables of the PSAT toolbox and handy registration of numbers is avoided. </p>
Denúncias da enfermagem brasileira sobre a exposição a riscos laborais durante a pandemia de COVID-19
Authors: Guimarães Ximenes Neto Francisco Rosemiro , Machado Maria Helena , Pinheiro Freire Neyson , Neri da Silva Manoel Carlos , Pereira dos Santos Betânia Maria , Carvalho de Mesquita Werner Wermelinger Mônica 
Published: July 2022

Objetivo: Refletir sobre os aspectos relacionados ao trabalho da equipe de Enfermagem, durante a pandemia da COVID-19 no Brasil. Métodos: Trata-se de uma reflexão sobre alguns aspectos das condições de trabalho e a exposição aos riscos í saúde dos profissionais de Enfermagem no Brasil, fundamentada nas informações do Observatório de Enfermagem e dos relatórios de fiscalização do Conselho Federal de Enfermagem (COFEN), e da Pesquisa Perfil da Enfermagem no Brasil. Resultados: Os profissionais de Enfermagem brasileiros tem enfrentado duras condições de trabalho, a exemplo da insuficiência e a inadequação dos Equipamentos de Proteção Individual (EPI) e o subdimensionamento das equipes, com isso aumentando os riscos í saúde dos trabalhadores. Conclusões: A pandemia exacerbou problemas enfrentados pelos profissionais de Enfermagem, e o déficit de EPI com o subdimensionamento das equipes e a sobrecarga de trabalho podem estar associados ao elevado número de óbitos de profissionais durante o perí­odo analisado.
Condutas do enfermeiro em cuidados paliativos: uma revisão integrativa
Authors: De Souza Tony José , Machao dos Santos Coelho Amanda Gabrielly , Correia de Lima Laiane Luzia , Vicente de Assis Julia Maria , Conceição Santos Pires Jussara , Da Silva Lima Solange 
Published: July 2022

Objetivo: Reconhecer as principais condutas do profissional enfermeiro na assistência de enfermagem ao paciente em cuidados paliativos. Método: Revisão integrativa de literatura realizada entre março a junho de 2021, desenvolvida obedecendo as seguintes etapas: 1ª etapa (elaboração da pergunta norteadora); 2ª etapa (definição das fontes de informações, e critérios de inclusão e exclusão; 3ª etapa (coleta de dados, leitura e seleção dos artigos); 4ª etapa (interpretação dos resultados e elaboração das reflexões do estudo). Resultados: A coleta de dados utilizando os descritores cuidados paliativos; cuidados paliativos na terminalidade da vida; enfermagem de cuidados paliativos na terminalidade da vida resultou na seleção de 81 artigos, dos quais 08 artigos atenderam os critérios de inclusão e foram utilizados para elaboração deste estudo. Considerações finais: As condutas do profissional enfermeiro resultam na prestação de cuidados alicerçados na humanização e bioética, garantindo o respeito í dignidade humana do paciente e incluem a intervenção em sintomas de natureza fí­sica, social e emocional.
PENAMBATAN MOLEKUL SENYAWA VOLATIL EKSTRAK DIKLOROMETANA SAMBILOTO TERHADAP JALUR PENSINYAL EPIDERMAL GROWTH FACTOR RECEPTOR
Authors: Faisal Muhammad , Nurlaili Nurlaili , Graidist Potchanapond , Tipmanee Varomyalin 
Published: July 2022

EGFR oncoprotein has been commonly studied in combating cell cancer development. However, until this moment the EGFR inhibitors were reported to cause other health issues. Plant extracts are trusted as the potential inhibitor of EGFR expression level without affect our health. We previously observed seventeen volatile compounds in the dichloromethane extract of Andrographis paniculata. Our objective was to analyze the interaction of volatile compounds from the dichloromethane extract of Andrographis paniculata on human EGFR pathway. In silico technique with ligand-receptor molecular docking was used in this study. The structure of volatile compounds was set as the ligands. EGFR, PIK3CA, KRAS-GTP, BRAF V600E, and AKT protein structures were assigned as the receptors. PyRx and Biovia Discovery Studio were used in this docking study. Drug-likeness and lead-likeness properties were appraised by SwissADME and Pre-ADME/Tox web tools. Beta-amyrin and stigmasterol showed the highest binding affinity to EGFR oncoproteins. PIK3CA, AKT, and KRAS-GTP, BRAF V600E was bound to beta-amyrin and stigmasterol, respectively. Those compounds structurally showed drug-likeness and non-mutagenic. Briefly, beta-amyrin and stigmasterol will be potentially used as the inhibitors of selected oncoproteins. In vitro technique and animal model are suggested to be performed to validate the mutagenic mechanisms of beta-amyrin and stigmasterol
TOKSISITAS GETAH EUPHORBIA MILII TERHADAP PERTUMBUHAN RUMPUT TEKI (CYPERUS ROTUNDUS)
Authors: Habibi Mohammad Wildan , As'ari Hasyim 
Published: July 2022

Arus penelitian saat ini menunjukkan bahwa pengendalian tanaman gulma secara hayati dengan prinsip back to nature menjadi marak dikarenakan faktor keamanan, jumlah populasi, nilai ekonomi yang jauh lebih baik dibandingkan dengan menggunakan penggunaan pembasmi gulma buatan yang cenderung merusak ekosistem dan pencemaran lingkungan sekitarnya. Alternatif bahan yang dapat digunakan dalam bioherbisida ini yaitu menggunakan getah tanaman euphorbia milii. Tujuan penelitian ini untuk mengetahui toksisitas getah tanaman Euphorbia milii dalam rangka menghambat tanaman rumput teki (Cyperus rotundus). Pendekatan dalam penelitian ini merupakan eksperimen laboratoris. Sedangkan jenis penelitian ini termasuk deskriptif eksploratif. Hasil dari penelitian ini dapat disimpulkan bahwa granul Euphorbia milii memiliki nilai LC50 = 1,08%, nilai LT50 = 8,31 hari, yang berarti untuk mebunuh 50% rumput teki membutuhkan konsentrasi 1,08% dalam waktu 8,31 hari.
Precise Positions of Five Major Uranian Satellites During 2008–2014 Based on Gaia EDR3*
Authors: Zhang H. Y. , Qiao R. C. , Yu Y. , Yan D. , Cheng X. , Tang K. , Mao Y. D. 
Published: July 2022

Abstract
The five major Uranian satellites (Ariel, Umbriel, Titania, Oberon, and Miranda) were observed by a 1.56 m telescope at Sheshan Station of Shanghai Astronomical Observatory during 2008–2014 and a total of 1915 positions of these five satellites were presented in this paper. Since all five satellites are close to Uranus, their positions are affected by the uneven background, which is caused by the halo of Uranus. The median filtering method is used to remove the influence of the halo of the bright Uranus, which also made the rate of target detection increase by 30%–100%, especially for Miranda. Gaia EDR3 is used as the reference catalog when calculating positions of the five satellites. A comparison between our positions with the theoretical positions of the satellites from IMCCE is given. Such precise positions over a long time will be very helpful to improve the orbit parameters of the five major Uranian satellites.
LoVoCCS. I. Survey Introduction, Data Processing Pipeline, and Early Science Results
Authors: Fu Shenming , Dell’Antonio Ian , Chary Ranga-Ram , Clowe Douglas , Cooper M. C. , Donahue Megan , Evrard August , Lacy Mark , Lauer Tod , Liu Binyang , McCleary Jacqueline , Meneghetti Massimo , Miyatake Hironao , Montes Mireia , Natarajan Priyamvada , Ntampaka Michelle , Pierpaoli Elena , Postman Marc , Sohn Jubee , Umetsu Keiichi , Utsumi Yousuke , Wilson Gillian 
Published: July 2022

Abstract
We present the Local Volume Complete Cluster Survey (LoVoCCS; we pronounce it as “low-vox” or “law-vox,” with stress on the second syllable), an NSF’s National Optical-Infrared Astronomy Research Laboratory survey program that uses the Dark Energy Camera to map the dark matter distribution and galaxy population in 107 nearby (0.03 < z < 0.12) X-ray luminous ([0.1–2.4 keV] L
X500 > 1044 erg s−1) galaxy clusters that are not obscured by the Milky Way. The survey will reach Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) Year 1–2 depth (for galaxies r = 24.5, i = 24.0, signal-to-noise ratio (S/N) > 20; u = 24.7, g = 25.3, z = 23.8, S/N > 10) and conclude in ∼2023 (coincident with the beginning of LSST science operations), and will serve as a zeroth-year template for LSST transient studies. We process the data using the LSST Science Pipelines that include state-of-the-art algorithms and analyze the results using our own pipelines, and therefore the catalogs and analysis tools will be compatible with the LSST. We demonstrate the use and performance of our pipeline using three X-ray luminous and observation-time complete LoVoCCS clusters: A3911, A3921, and A85. A3911 and A3921 have not been well studied previously by weak lensing, and we obtain similar lensing analysis results for A85 to previous studies. (We mainly use A3911 to show our pipeline and give more examples in the Appendix.)