bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma metabolomic signatures of obesity and risk of type 2 diabetes
Authors: Pan Xiong‐Fei , Chen Zsu‐Zsu , Wang Thomas J. , Shu Xiang , Cai Hui , Cai Qiuyin , Clish Clary B. , Shi Xu , Zheng Wei , Gerszten Robert E. , Shu Xiao‐Ou , Yu Danxia 
Published: September 2022

AbstractObjectiveThe mechanisms linking obesity to type 2 diabetes (T2D) are not fully understood. This study aimed to identify obesity‐related metabolomic signatures (MESs) and evaluated their relationships with incident T2D.MethodsIn a nested case‐control study of 2076 Chinese adults, 140 plasma metabolites were measured at baseline, linear regression was applied with the least absolute shrinkage and selection operator to identify MESs for BMI and waist circumference (WC), and conditional logistic regression was applied to examine their associations with T2D risk.ResultsA total of 32 metabolites associated with BMI or WC were identified and validated, among which 14 showed positive associations and 3 showed inverse associations with T2D; 8 and 18 metabolites were selected to build MESs for BMI and WC, respectively. Both MESs showed strong linear associations with T2D: odds ratio (95% CI) comparing extreme quartiles was 4.26 (2.00‐9.06) for BMI MES and 9.60 (4.22‐21.88) for WC MES (both p‐trend < 0.001). The MES‐T2D associations were particularly evident among individuals with normal WC: odds ratio (95% CI) reached 6.41 (4.11‐9.98) for BMI MES and 10.38 (6.36‐16.94) for WC MES. Adding MESs to traditional risk factors and plasma glucose improved C statistics from 0.79 to 0.83 (p < 0.001).ConclusionsMultiple obesity‐related metabolites and MESs strongly associated with T2D in Chinese adults were identified.
Behavior of melt electrospinning/blowing for polypropylene fiber fabrication
Authors: Lim Jihwan , Choi Sejin , Kim Han Seong 
Published: September 2022

AbstractThe fabrication process of polymer fibers has been analyzed in various ways, and several studies have been conducted to develop new processes and optimize existing ones. Several studies have been conducted on the electrospinning process, which can easily fabricate nanofibers, and the development of materials manufactured through electrospinning has also been investigated. However, research on the nanofiber fabrication and processing of thermoplastic polymers, such as polypropylene (PP), polyethylene and polyethylene terephthalate, is relatively lacking. Therefore, research on nanofiber fabrication is essential. In this study, PP fibers were successfully manufactured through a melt electrospinning/blowing process, which combined melt blowing and electrospinning. To analyze the melt electrospinning/blowing process, the dynamic behavior of the spinning process was observed using a charge‐coupled device camera in real time, and the effects of the different spinning conditions were compared and analyzed. As the hot air or high voltage was increased, the spinning jet area tended to increase. In addition, the average diameter of the fabricated fibers tended to decrease as a high voltage was applied at a hot air pressure of 0.01 MPa; conversely, the average diameter tended to increase at a hot air pressure of 0.03 MPa. A similar trend was observed for the tensile stresses in the PP web fabrics. The polymer fibers produced by this melt electrospinning/blowing process can be applied as a production process for nanomembranes, filters and battery separators. © 2022 Society of Industrial Chemistry.
Automated imaging of duckweed growth and development
Authors: Cox Kevin L. , Manchego Jordan , Meyers Blake C. , Czymmek Kirk J. , Harkess Alex 
Published: September 2022

AbstractDuckweeds are the smallest angiosperms, possessing a simple body architecture and highest rates of biomass accumulation. They can grow near‐exponentially via clonal propagation. Understanding their reproductive biology, growth, and development is essential to unlock their potential for phytoremediation, carbon capture, and nutrition. However, there is a lack of non‐laborious and convenient methods for spatially and temporally imaging an array of duckweed plants and growth conditions in the same experiment. We developed an automated microscopy approach to record time‐lapse images of duckweed plants growing in 12‐well cell culture plates. As a proof‐of‐concept experiment, we grew duckweed on semi‐solid media with and without sucrose and monitored its effect on their growth over 3 days. Using the PlantCV toolkit, we quantified the thallus area of individual plantlets over time, and showed that L. minor grown on sucrose had an average growth rate four times higher than without sucrose. This method will serve as a blueprint to perform automated high‐throughput growth assays for studying the development patterns of duckweeds from different species, genotypes, and conditions.
Cibalackrot‐type compounds: Stable singlet fission materials with aromatic ground state and excited state
Authors: Zeng Weixuan , Szczepanik Dariusz W. , Bronstein Hugo 
Published: September 2022

AbstractSinglet fission is a multiexciton generation process, where one singlet exciton is absorbed and two triplet excitons are produced. The potential of more efficient photovoltaic devices utilizing singlet fission materials has attracted wide interests for tuneable, stable organic chromophores with suitable excited‐state ordering. The strict energetic requirements hinder the exploration of novel organic materials, and most well‐known singlet fission materials, linear acenes, are considered to be unstable in their excited states. To solve the stability issue, excited‐state aromaticity provides a feasible research option, from which a few chromophores have been designed and studied. This review describes indolonaphthyridine (IND) derivative chromophores and discusses their ability to undergo singlet fission with superior ambient stability. Deepened theoretical analysis taking into account the excited‐state Hückel‐aromatic and diradical characters rationalizes the special properties of these chromophores. Moreover, the improved understanding of the aromatic character enables us to outline a feasible design strategy suitable for other scaffolds undergo singlet fission and excited‐state aromaticity. Hopefully, this review can light a fire on the way toward various novel singlet fission chromophores designed based on the excited‐state aromatic view.
Reintroduction of Buchanania barberi, a critically endangered tree endemic to the south Western Ghats of Kerala, India
Authors: Dhyani Anurag , Bindu Syamala , Abinlal Kavungulla Chalil , Anilkumar Chandran 
Published: September 2022

Societal Impact StatementIndia is credited with 2603 tree species, and the Global Tree Assessment confirmed that 469 of these species are threatened with extinction. Urgent restoration and conservation efforts are required to prevent the loss of tree diversity. The present study is the first published attempt to reintroduce Buchanania barberi, a Critically Endangered tree endemic to the south Western Ghats (UNESCO World Heritage Site) of Kerala, India, which has only two surviving mature individuals. The techniques and approaches applied here may provide guidance for implementing translocation programmes for this rare species and also for other International Union for Conservation of Nature (IUCN) Red Listed species of the genus globally.
Modeling statically indeterminate reinforced concrete slabs and beams under fire conditions
Authors: Bischof Patrick , Morf Urias , Bamonte Patrick , Kaufmann Walter 
Published: September 2022

AbstractEN 1992‐1‐2 generally limits the redistribution of bending moments from the intermediate supports to the span for continuous reinforced concrete slabs and beams in fire conditions to 15%. While higher redistributions are allowed if sufficient rotation capacity is provided, EN 1992‐1‐2 does not indicate how to assess the rotation capacity. However, plastic hinges caused by the rotation demand under fire conditions are highly relevant when predicting the global response and structural safety of a structure (partially) exposed to fire. Rotation capacity is specifically necessary at support regions subjected to negative bending and fire, where concrete in compression undergoes thermal degradation while the tension chord remains close to ambient temperature. This article presents a comprehensive model for the behavior of statically indeterminate members in fire conditions, enabling to estimate whether sufficient rotation capacity is provided. Material properties specified by EN 1992‐1‐2 are applied combined with complementary considerations concerning (i) the biaxial compressive strength of concrete, (ii) strain hardening and limitations of the ultimate strain of reinforcement, as well as (iii) tension stiffening. Tension stiffening detrimentally influences the ductility of the tension chord, limiting the rotation capacity. When comparing predictions obtained by the model to experimental results given in the literature, the correlation is good for the investigated one‐way continuous slabs and beams. However, considerable uncertainty exists regarding the type of concrete aggregate used. Moreover, uncertainties concerning the behavior of concrete under compression and fire conditions are highly relevant for modeling the region of supports with rotational restraint.
ODDE and Gender
Authors: von Prümmer Christine 
Published: September 2022

AbstractGender and the concern with gender issues is important for open and distance education (ODE) which is associated with the provision of educational opportunities for minority groups. In countries and cultures the world over, including Western industrialized societies, girls and women are educationally disadvantaged compared to their male counterparts. This educational discrimination is especially prevalent in social minorities. Since 1982, with the start of the Women’s International Network WIN within the International Council for Open and Distance Education ICDE, women working in ODE have brought a feminist and gender perspective to their own situation and to that of women distance students. A manifestation of this was the proliferation of women’s/gender studies into ODE curricula. With the goal of equal access and conditions for women to succeed, women working in ODE researched and analyzed the cultural and social factors underlying the inequalities and identified ways for redressing gender imbalances. The paper discusses four areas of inequality and points out ways for the empowerment of women: (1) gender roles and the social division of labor, (2) learning environments, (3) access equity, and (4) course content and choice of subject. A focus on gendered access and use of technology highlights factors affecting women’s participation in e-learning and the way in which they use electronic communication for overcoming isolation, for networking, and for empowerment.
Macaulay matrix for Feynman integrals: linear relations and intersection numbers
Authors: Chestnov Vsevolod , Gasparotto Federico , Mandal Manoj K. , Mastrolia Pierpaolo , Matsubara-Heo Saiei J. , Munch Henrik J. , Takayama Nobuki 
Published: September 2022

Abstract
We elaborate on the connection between Gel’fand-Kapranov-Zelevinsky systems, de Rham theory for twisted cohomology groups, and Pfaffian equations for Feynman Integrals. We propose a novel, more efficient algorithm to compute Macaulay matrices, which are used to derive Pfaffian systems of differential equations. The Pfaffian matrices are then employed to obtain linear relations for $$ \mathcal{A} $$
A
-hypergeometric (Euler) integrals and Feynman integrals, through recurrence relations and through projections by intersection numbers.
Celestial blocks and transverse spin in the three-point energy correlator
Authors: Chen Hao , Moult Ian , Sandor Joshua , Zhu Hua Xing 
Published: September 2022

Abstract
Quantitative theoretical techniques for understanding the substructure of jets at the LHC enable new insights into the dynamics of QCD, and novel approaches to search for new physics. Recently, there has been a program to reformulate jet substructure in terms of correlation functions, $$ \left\langle \mathcal{E}\left({\overrightarrow{n}}_1\right)\mathcal{E}\left({\overrightarrow{n}}_2\right)\cdots \mathcal{E}\left({\overrightarrow{n}}_k\right)\ \right\rangle $$

E

n
→

1

E

n
→

2

⋯
E

n
→

k

, of light-ray operators, $$ \mathcal{E}\left(\overrightarrow{n}\right) $$
E

n
→

, allowing the application of techniques developed in the study of Conformal Field Theories (CFTs). In this paper we further develop these techniques in the particular context of the three-point correlator $$ \left\langle \mathcal{E}\left({\overrightarrow{n}}_1\right)\mathcal{E}\left({\overrightarrow{n}}_2\right)\mathcal{E}\left({\overrightarrow{n}}_3\right)\ \right\rangle $$

E

n
→

1

E

n
→

2

E

n
→

3

, using recently computed perturbative data in both QCD and $$ \mathcal{N} $$
N
= 4 sYM. We derive the celestial blocks appearing in the light-ray operator product expansion (OPE) of the three-point correlator, and use the Lorentzian inversion formula to extract the spectrum of light-ray operators appearing in the expansion, showing, in particular, that the OPE data is analytic in transverse spin. Throughout our presentation, we highlight the relation between the OPE approach, and more standard splitting function based approaches of perturbative QCD, emphasizing the utility of the OPE approach for incorporating symmetries in jet substructure calculations. We hope that our presentation introduces a number of new techniques to the jet substructure community, and also illustrates the phenomenological relevance of the study of light-ray operators in the OPE limit to the CFT community.
Bone marrow aspirate concentrate quality is affected by age and harvest site
Authors: Cavallo Carola , Boffa Angelo , de Girolamo Laura , Merli Giulia , Kon Elizaveta , Cattini Luca , Santo Emma , Grigolo Brunella , Filardo Giuseppe 
Published: September 2022

Abstract
Purpose
To compare the number and properties of bone marrow stromal cells (BMSCs) collected from bone marrow aspirate concentrate (BMAC) obtained from different harvest sites and from patients of different ages.

Methods
BMAC was obtained from two groups of patients based on age (n = 10 per group): 19.0 ± 2.7 years for the younger and 56.8 ± 12.5 for the older group. In the latter, BMAC was obtained from both iliac crest and proximal tibia for a donor-matched analysis. Mononucleated cell count and CFU-F assay were performed, together with phenotype characterization of BMSCs from iliac crest and proximal tibia, the study of chondrogenic and osteogenic differentiation capacity, histological staining and spectrophotometric quantification, and the analysis of mRNAs expression.

Results
Cells derived from iliac crest and proximal tibia showed the same phenotypic pattern at flow cytometry, as well as similar chondrogenic and osteogenic potential. However, a significantly higher number of mononuclear cells per ml was observed in younger patients (3.8 ± 1.8 × 107) compared to older patients (1.2 ± 0.8 × 107) (p < 0.0005). The latter yield, obtained from the iliac crest, was significantly higher than resulting from the BMAC harvested from the proximal tibia in the same group of patients (0.3 ± 0.2 × 107, p < 0.0005). This result was confirmed by the CFU-F analysis at day 10 (15.9 ± 19.4 vs 0.6 ± 1.0, p = 0.001) and day-20 (21.7 ± 23.0 vs 2.9 ± 4.2, p = 0.006).

Conclusion
Harvest site and age can affect the quality of BMAC. BMSCs obtained from iliac crest and proximal tibia present comparable mesenchymal markers expression as well as osteogenic and chondrogenic differentiation potential, but iliac crest BMAC presents a four times higher number of mononucleated cells with significantly higher clonogenic capacity compared to the tibia. BMAC of younger patients also had a three-time higher number of mononucleated cells. The identification of BMAC characteristics could help to optimize its preparation and to identify the most suitable indications for this orthobiologic treatment in the clinical practice.
Reduced two-bound core games
Authors: Gong Doudou , Dietzenbacher Bas , Peters Hans 
Published: September 2022

AbstractThis paper studies Davis–Maschler reduced games of two-bound core games and shows that all these reduced games with respect to core elements are two-bound core games with the same pair of bounds. Based on associated reduced game properties, we axiomatically characterize the core, the nucleolus, and the egalitarian core for two-bound core games. Moreover, we show that the egalitarian core for two-bound core games is single-valued and we provide an explicit expression.
Microbiological findings in prepubertal and pubertal girls with vulvovaginitis
Authors: Baka Stavroula , Demeridou Stiliani , Kaparos George , Tsoutsouras Konstantinos , Touloumakos Sotirios , Dagre Maria , Meretaki Sofia , Chasiakou Anthia , Koumaki Vasiliki , Tsakris Athanasios 
Published: September 2022

AbstractVulvovaginitis is a common and challenging gynaecological problem in prepubertal and pubertal girls. Such an infection, owing to a wide range of aetiologies, if not responding to hygienic measures, needs further investigation through vaginal cultures, since treatment should be tailored accordingly. This study aimed to investigate the pathogens isolated in prepubertal and pubertal girls with signs and symptoms of vulvovaginitis. A total of 2314 symptomatic girls, 1094 prepubertal and 1220 pubertal, aged 2 to 16 years, were included. Vaginal samples were inoculated on specific culture plates followed by incubation in aerobic, anaerobic or CO2 atmosphere at 37 °C for 24 or 48 h, as appropriate. The identification of the isolated pathogens was carried out using Gram stain, conventional methods and the automated system VITEK 2 (BioMerieux, Marcy l’Etoile, France). Positive cultures were obtained from 587 (53.7%) of prepubertal girls and 926 (75.9%) of pubertal girls. A total of 613 and 984 pathogens were detected in prepubertal and pubertal subjects, respectively. Isolated bacteria included 40.1% and 22.8% Gram-positive cocci, 35.6% and 24.8% Gram-negative rods in the prepubertal and pubertal groups, respectively, with faecal pathogens being the most prevalent. Bacterial vaginosis was diagnosed in 22.8% of prepubertal and 37.9% of pubertal girls. Candida species were isolated mostly in the pubertal girls (14.5%).Conclusion: Culture results should be evaluated with caution in children with vulvovaginitis. In the prepubertal girls, the most common isolated pathogens were opportunistic bacteria of faecal origin while girls in late puberty were more susceptible to bacterial vaginosis and vulvovaginal candidiasis.

What is Known:• Vulvovaginitis is the most frequent and challenging reason for referral to paediatric and adolescent gynaecology services.• Microbiological examination can prove to be a significant tool to help diagnosis although results should be evaluated with caution in children.

What is New:• Significantly more positive vaginal cultures and pathogens were recorded in symptomatic pubertal girls compared to prepubertal children.• The prevalence of bacterial vaginosis was increased in both prepubertal and pubertal girls with vulvovaginitis although significantly more in girls at puberty.
Behavioral Interventions Targeting Base of Tongue to Posterior Pharyngeal Wall Approximation: A Scoping Review
Authors: Doeltgen Sebastian H. , Francis Rebecca , Daniels Stephanie K. , Kaur Harsharan , Mohammadi Leila , Murray Joanne 
Published: September 2022

AbstractPharyngeal pressure generated by approximation of the base of tongue to the posterior pharyngeal wall (BOT-PPW approximation) is critical for efficient pharyngeal bolus passage and is a frequent goal of dysphagia management. This scoping review evaluated behavioral interventions available to improve BOT-PPW approximation. We searched MEDLINE, CINAHL, Ovid Emcare, Web of Science, SCOPUS, and ProQuest for studies that met the following criteria: (i) behavioral interventions targeting BOT-PPW approximation, which (ii) were assessed using BOT-PPW-specific outcome measures, and (iiia) performed over a period of time (Review Part 1) or (iiib) studied immediate effects (Review Part 2). Study quality was rated using the GRADE framework. Data were extracted and synthesized into dominant themes. Of the 150 studies originally identified, three examined long-term effects (two single cases studies of individuals with dysphagia, and a third study evaluating effortful swallowing in healthy individuals). BOT-PPW approximation only increased in the two single case studies. Twenty-one studies evaluating immediate effects were categorized as follows: (1) effortful swallowing, (2) Mendelsohn maneuver, (3) tongue-hold maneuver, (4) super supraglottic swallowing maneuver, and (5) non-swallowing exercises. Across all studies, varying levels of success in increasing BOT-PPW approximation were reported. Four of 21 immediate effects studies evaluated patients with demonstrated swallowing impairment, whereas 17 studies evaluated healthy adults. Quality assessment revealed low strength of the existing evidence base. The evidence base for rehabilitative interventions targeting BOT-PPW approximation is severely limited and translation is hindered by small sample sizes and methodological limitations. Further clinical research is warranted.
Education and Study Concepts at the European University Alliance EURECA-PRO
Authors: Drebenstedt Carsten , Sishchuk Julia , Palmer Luke , Bongaerts Jan , Kleeberg Kirstin 
Published: September 2022

AbstractEducation is an essential core task of EURECA-PRO and consists of designing and implementing new study programmes at all levels (Bachelor’s, Master’s, and doctoral), developing new, supplementary modules and promoting innovative teaching methods. While spreading and encouraging excellence in learning and teaching is a fundamental part of all higher education institutions, it is especially important for EURECA-PRO in the development of new programmes, courses, and educational concepts across all partner universities. This development presents an opportunity to cement and enhance excellence in teaching and learning across the alliance and to prioritise students’ educational experience.
Computable centering methods for spiraling algorithms and their duals, with motivations from the theory of Lyapunov functions
Authors: Lindstrom Scott B. 
Published: September 2022

AbstractFor many problems, some of which are reviewed in the paper, popular algorithms like Douglas–Rachford (DR), ADMM, and FISTA produce approximating sequences that show signs of spiraling toward the solution. We present a meta-algorithm that exploits such dynamics to potentially enhance performance. The strategy of this meta-algorithm is to iteratively build and minimize surrogates for the Lyapunov function that captures those dynamics. As a first motivating application, we show that for prototypical feasibility problems the circumcentered-reflection method, subgradient projections, and Newton–Raphson are all describable as gradient-based methods for minimizing Lyapunov functions constructed for DR operators, with the former returning the minimizers of spherical surrogates for the Lyapunov function. As a second motivating application, we introduce a new method that shares these properties but with the added advantages that it: (1) does not rely on subproblems (e.g. reflections) and so may be applied for any operator whose iterates have the spiraling property; (2) provably has the aforementioned Lyapunov properties with few structural assumptions and so is generically suitable for primal/dual implementation; and (3) maps spaces of reduced dimension into themselves whenever the original operator does. This makes possible the first primal/dual implementation of a method that seeks the center of spiraling iterates. We describe this method, and provide a computed example (basis pursuit).