bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical, mechanical, and antimicrobial properties of bio‐based composites of poly(L‐lactic acid) and D‐limonene/β‐cyclodextrin inclusion complex
Authors: Dobrzyńska‐Mizera Monika , Knitter Monika , Szymanowska Daria , Mallardo Salvatore , Santagata Gabriella , Di Lorenzo Maria Laura 
Published: January 2022

AbstractComposites made of poly(l‐lactic acid) (PLLA) and β‐cyclodextrin/D‐limonene inclusion complex (CD‐Lim) are prepared to develop novel food packaging material with antibacterial properties. The composites are formulated with bio‐based materials that are also biodegradable. The addition of CD‐Lim to PLLA results in enhanced permeability and water uptake. Optical properties of PLLA/CD‐Lim composites also significantly vary compared to plain PLLA, with partial loss of transparency and gloss, but sizably increased barrier to UV light, which imparts protection from oxidation to lipid‐containing food. The mechanical properties of the composite films are also affected by composition. Most notably, PLLA films containing CD‐Lim display significant antibacterial and antifungal properties, proving their potential as active food packaging films.
Ligand effects in rhodium complexes for chemical NADH regeneration
Authors: Fard Pegah Tavakoli , Kim Kayoung , Lee Sohyun , Kim Jinheung 
Published: January 2022

AbstractVarious (pentamethylcyclopentadienyl)‐rhodium(III) complexes comprising aromatic bidentate ligands [(Cp*)Rh(L)Cl]+ (Cp* = pentamethylcyclopentadienyl, L = 2,2′‐bipyridine, 1,10‐phenanthroline, and their derivatives) were prepared to compare their reactivities of chemical cofactor regeneration. When the catalytic NADH regeneration was performed with sodium formate−, the reaction rates were compared with six Rh(III) complexes. The kinetics of the reactions including kinetic isotope effects are also studied in the chemical NADH regeneration. The Rh(III) complexes react with formate efficiently to afford the intermediates [(Cp*)Rh(L)(H)]+ and CO2. The electronic and steric effects of the ligands of the Rh complexes were observed on the reaction rates. The overall reaction rates of the NADH regeneration were also obtained using DCOO− in H2O. Such H/D exchange rates of [(Cp*)Rh(L)(H)]+ and the observation of a deuterium kinetic isotope provide valuable mechanistic insight into the catalytic NADH regeneration.
Sensitivity of time‐resolved diffraction data to changes in internuclear distances and atomic positions
Authors: Jeong Haeyun , Ki Hosung , Kim Jong Goo , Kim Jungmin , Lee Yunbeom , Ihee Hyotcherl 
Published: January 2022

AbstractTime‐resolved x‐ray liquidography (TRXL) is a powerful technique to study molecular structural dynamics in the solution phase. Typically, a TRXL experiment is conducted during limited beamtime at a beamline of a synchrotron or an x‐ray free‐electron laser, demanding a proper design and careful planning. In this regard, the optimal q range needs to be determined to find the optimal x‐ray energy and sample‐to‐detector distance. For such purpose, here, we present effective ways to quantify the sensitivity of the TRXL data as a function of q to various factors such as the atomic positions, internuclear distances, solvent cage, and bulk solvent. The developed approaches are also applicable to other types of time‐resolved diffraction, such as ultrafast electron diffraction.
Exploring antecedents of innovations for small‐ and medium‐sized enterprises' environmental sustainability: An interpretative framework
Authors: Castellano Rosalia , Punzo Gennaro , Scandurra Giuseppe , Thomas Antonio 
Published: January 2022

AbstractThe need to pursue sustainable development has become a central topic in Western countries due to citizens' greater sensitivity to improving environmental and social conditions. Companies can reach this objective more easily through green innovations, which are now considered a strategic opportunity that simultaneously allows for adherence to sustainable development criteria and the pursuit of competitive advantages. Scholars have identified the determinants that encourage companies to adopt green innovations, but the outcomes of their investigations thus far have often been ambiguous and contradictory. Our paper proposes an interpretative framework for addressing such inconsistencies. Using the partial least squares structural equation modelling (PLS‐SEM) methodology, we validate this framework on a sample of small‐ and medium‐sized enterprises (SMEs) and show that SMEs' choices are influenced by cultural elements and stimulated by the prospect of obtaining economic advantages over competitors. SMEs also pay close attention to stakeholder solicitations, while public administration does not affect their eco‐innovating choices. The results have policy implications for executives and insiders.
The impact of environmental dynamism on low‐carbon practices and digital supply chain networks to enhance sustainable performance: An empirical analysis
Authors: Sharma Manu , Kumar Anil , Luthra Sunil , Joshi Sudhanshu , Upadhyay Arvind 
Published: January 2022

AbstractDigital supply chains have revolutionised manufacturing firms by helping them address the challenges of a dynamic environment. Firms implement low‐carbon practices to achieve environmental sustainability. This paper explores whether digital supply chain networks can influence the sustainable performance of manufacturing firms and the mediating effect of low‐carbon practices in the contingency factor of environmental dynamism (ED). The relationship is examined in terms of information processing theory and stakeholder theory and from the perspective of a resource‐based view (RBV). The proposed framework is tested using structural equation modelling. The results show that low‐carbon practices have a partial mediation effect on digital supply chains and the sustainable performance of manufacturing firms. Furthermore, ED moderates the relationship of low‐carbon practices and digital supply chain networks. The study can support managers as they design strategies to move towards a low‐carbon economy, enhancing the firm's sustainable performance in accordance with ED. The current study strongly contributes to the literature on business strategy and the environment, as it has both theoretical and practical implications.
Predictors and long‐term outcomes of in‐hospital switching from clopidogrel to ticagrelor among patients with acute coronary syndrome undergoing percutaneous coronary intervention
Authors: Chen Sanbao , Li Jing , Qiu Miaohan , Ma Sicong , Jiang Zaixin , Na Kun , Qi Zizhao , Li Yuzhuo , Li Yi , Han Yaling 
Published: January 2022

AbstractThis study evaluated clinical outcomes of switching from clopidogrel to ticagrelor in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The clinical benefit of in‐hospital switching from clopidogrel to ticagrelor in these patients remains unclear. Among patients with ACS initially receiving clopidogrel, logistic regression was used to identify independent predictors of switching to ticagrelor. Multivariable Cox regression was used to compare efficacy and safety between switching to ticagrelor and continuing clopidogrel. The primary endpoint was net adverse clinical events (NACEs) at 12 months, a composite of major adverse cardiovascular events (MACE) and Bleeding Academic Research Consortium (BARC) type 2/3/5 bleeding. Among 10,519 patients initially receiving clopidogrel, 1405 (13.4%) were switched to ticagrelor at discharge. Stent number, left main artery lesions, diabetes, male sex, age, estimated glomerular filtration rate of <45 ml/min/1.73 m2, and history of PCI or stroke were identified as independent predictors of switching to ticagrelor. The rate of NACE (hazard ratio [HR]: 1.51; 95% confidence interval [CI]: 1.18–1.91) or BARC type 2/3/5 bleeding (HR: 2.01; 95% CI: 1.52–2.66) was significantly higher in patients switching to ticagrelor than in those continuing clopidogrel. The risk of MACE was comparable between both the groups (HR: 0.71; 95% CI: 0.41–1.22). In real‐world practice, in‐hospital switching from clopidogrel to ticagrelor was independently associated with several clinical factors. Patients switching to ticagrelor had a higher rate of NACE or BARC type 2/3/5 bleeding than those continuing clopidogrel, without any reduction in the MACE rate.
Effects of warming on starch structure, rice flour pasting property, and cooked rice texture in a double rice cropping system
Authors: Yang Taotao , Yang Huifang , Zhang Bin , Wu Longmei , Huang Qing , Zou Jixiang , Jiang Yu , Zhang Nan 
Published: January 2022

AbstractBackground and objectivesClimate warming has significant effects on rice quality. However, the effects of warming on starch structure, rice flour pasting properties, and cooked rice texture are unclear in double rice cropping systems. Therefore, a free‐air temperature increase experiment was conducted with two indica rice cultivars. The objectives of this study were to explore the changes in rice flour pasting properties and cooked rice texture under warming conditions and their relationships with starch structures.FindingsUnder warming conditions, rice starch had a lower amylose content (Peak 3) and proportion of long amylopectin branch chains (B3 chains) but a higher proportion of short amylopectin branch chains (A chains and B1 chains), amylopectin branching degree, relative crystallinity, ratio of 1045/1022 cm−1, and swelling power. Compared to the control treatment, warming significantly increased the peak viscosity, breakdown, and pasting temperature but decreased the setback of rice flour. Moreover, the hardness of cooked rice was significantly decreased, while its stickiness was significantly increased under warming conditions.ConclusionsThe changes in starch molecular structures resulted in lower hardness and setback but a higher stickiness, peak viscosity, breakdown, and pasting temperature of cooked rice or rice flour, which means better eating quality and worse cooking quality of double‐cropped indica rice under climate warming conditions.Significance and noveltyThese findings are expected to provide important information for improving rice cooking and eating quality and developing the rice industry under future climate warming conditions.
Unexplained left Mullerian agenesis with agenesis of left kidney: A case report
Authors: Mamah Johnbosco E. , Ofodile Obiamaka O. , Onyebuchi Azubuike K. , Otu Chichetaram R. , Aliyu‐Abubakar Zubaida , Egbuonu Nnaemeka 
Published: January 2022

AbstractThe exact incidence of Mullerian agenesis is unknown because women with this condition might be asymptomatic and diagnosis is mostly incidental. We report an incidental finding of left Mullerian agenesis involving the left fallopian tube, left ovary, and the left kidney following evaluation and treatment for a right tubal ectopic pregnancy.
Fatal outcome following multiple bee stings: A rare case
Authors: Fakhar Mahdi , Zakariaei Zakaria , Sharifpour Ali , Soleymani Mostafa , Zakariaei Ashkan 
Published: January 2022

AbstractAnaphylactic shock is an unexpected, life‐threatening, and sometimes fatal occurrence that affects patients in 75% of instances without a prior history of allergies. The severity of the reaction can vary among individuals. We report a case who died suddenly after being stung by bees in various parts of his body.
Ni(OH)2/NiSe Nanoparticles Supported on Carbon Microspheres for Long‐Life and High‐Performance Asymmetric Supercapacitors
Authors: Zhang Junye , Guo Hao , Yang Fan , Wang Mingyue , Zhang Tingting , Zhang Hao , Yang Wu 
Published: January 2022

AbstractThe application of Ni‐MOF in supercapacitors has received widespread attention, but its poor conductivity and bad stability hinder its application. Therefore, Ni‐MOF derived CMs@Ni(OH)2/NiSe with a core‐shell structure was designed. Here, carbon microspheres (CMs) were explored as the conductive substrate to enhance the stability and in situ prepared Ni‐MOF was anchored on the surface of CMs. Then, alkali‐treatment and selenylation were carried out on CMs@Ni−MOF to improve stability and conductivity. The obtained core‐shell nanostructure material possesses a high contact area, excellent synergistic effect and can provide more reactive active sites. The prepared CMs@Ni(OH)2/NiSe shows a higher specific capacitance (2106 F g−1) and excellent cycling performance with a capacitance retention of 95 % after 30000 cycles. Furthermore, the assembled CMs@Ni(OH)2/NiSe//AC device delivers a high energy density of 70.84 Wh kg−1 at the power density of 756.8 W kg−1 and maintains 100 % of the initial capacitance after 40000 cycles.
Structure‐Performance Relationship of LaFe1‐xCoxO3Electrocatalysts for Oxygen Evolution, Isopropanol Oxidation, and Glycerol Oxidation
Authors: Brix Ann Cathrin , Dreyer Maik , Koul Adarsh , Krebs Moritz , Rabe Anna , Hagemann Ulrich , Varhade Swapnil , Andronescu Corina , Behrens Malte , Schuhmann Wolfgang , Morales Dulce M. 
Published: January 2022

AbstractMitigating high energy costs related to sustainable H2production via water electrolysis is important to make this process commercially viable. Possible approaches are the investigation of low‐cost, highly active oxygen evolution reaction (OER) catalysts and the exploration of alternative anode reactions, such as the electrocatalytic isopropanol oxidation reaction (iPOR) or the glycerol oxidation reaction (GOR), offering the possibility of simultaneously lowering the anodic overpotential and generating value‐added products. A suitable class of catalysts are non‐noble metal‐based perovskites with the general formula ABO3, featuring rare‐earth metal cations at the A‐ and transition metals at the B‐site. We synthesised a series of LaFe1‐xCoxO3materials with x=0–0.70 by automated co‐precipitation at constant pH and subsequent calcination at 800 °C. X‐ray diffraction studies revealed that the phase purity was preserved in samples with x≤0.3. The activity towards the OER, iPOR, and GOR was investigated by rotating disk electrode voltammetry, showing a relation between structure and metal composition with the activity trends observed for the three reactions. Additionally, GOR product analysis via high‐performance liquid chromatography (HPLC) was conducted after 24 and 48 h electrolysis in a circular flow‐through cell setup, pointing out a trade‐off between activity and selectivity.
Transition Metal‐Free Synthesis of meta‐Bromo‐ and meta‐Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction
Authors: Staudt Markus , Cetin Adnan , Bunch Lennart 
Published: January 2022

AbstractAnilines are key constituents in biologically active compounds and often obtained from transition metal‐catalyzed coupling of an aryl halide with an amine. In this work, we report a transition metal‐free method for the synthesis of meta‐bromo‐ and meta‐trifluoromethylanilines starting from 3‐tribromomethylcyclopentanone or 3‐(2‐bromo‐2‐chloro‐1,1,1‐trifluoroethyl)cyclopentanone, respectively. The scope of the transformation is shown by application of primary, secondary and aromatic amines. The reaction proceeds in acceptable to high yields (20–81 %), and allows for the synthesis of anilines with substitution patterns otherwise difficult to access.
Electrochemical Synthesis of Isoxazolines: Method and Mechanism
Authors: Holman Samuel D. L. , Wills Alfie G. , Fazakerley Neal J. , Poole Darren L. , Coe Diane M. , Berlouis Leonard A. , Reid Marc 
Published: January 2022

AbstractAn electrochemical method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline in an electrochemically enabled regio‐ and diastereoselective reaction with electron‐deficient alkenes. Additionally, in‐situ reaction monitoring methods compatible with electrochemistry equipment have been developed in order to probe the reaction pathway. Supporting analyses from kinetic (time‐course) modelling and density functional theory support a stepwise, radical‐mediated mechanism, and discounts hypothesised involvement of closed shell [3+2] cycloaddition pathways.
Myocardial viability assessment and utility in contemporary management of ischemic cardiomyopathy
Authors: Katikireddy Chandra K. , Samim Arang 
Published: January 2022

AbstractBackgroundIn clinical practice, we encounter ischemic cardiomyopathy (ICM) with underlying viable, dysfunctional myocardium on a regular basis. Evidence from the Surgical Treatment for Ischemic Heart failure (STICH) and its Extension Study is supportive of improved outcomes with coronary revascularization, irrespective of myocardial viable status. However, Dobutamine stress echocardiography (DSE) and single‐photon emission computed tomography (SPECT), used in STICH to assess myocardial viability may fail to distinguish hibernating myocardium from scar due to suboptimal image resolution and poor tissue characterization.HypothesisCardiac magnetic resonance (CMR) and positron emission tomography (PET) can precisely quantify myocardial scar and identify metabolically active, viable myocardium respectively. Unlike DSE and SPECT, CMR and PET allow examining myocardial status as a contiguous spectrum from viable to partially viable myocardium with varying degrees of subendocardial scar and nonviable myocardium with predominantly transmural scar, the therapeutic and prognostic determinants of ICM.MethodsUnder the guidance of CMR and PET imaging, myocardium can be distinguished viable from partially viable with subendocardial scar and predominantly transmural scar. In ICM, optimal medical therapy and coronary revascularization of viable/partially viable myocardium but not transmural scar may improve outcomes in patients with acceptable procedural risk.ResultsCoronary revascularization of partially viable and viable myocardial territory may improve clinical outcomes by preventing future ischemic, infarct events and further worsening of left ventricular remodeling and function.ConclusionsWhen deciding if coronary revascularization is appropriate in a patient with ICM, it is essential to take a patient‐tailored, comprehensive approach incorporating myocardial viability, ischemia, and scar data with others such as procedural risk, and patient's comorbidities.
Radiation necrosis in renal cell carcinoma brain metastases treated with checkpoint inhibitors and radiosurgery: An international multicenter study
Authors: Lehrer Eric J. , Gurewitz Jason , Bernstein Kenneth , Patel Dev , Kondziolka Douglas , Niranjan Ajay , Wei Zhishuo , Lunsford L. Dade , Malouff Timothy D. , Ruiz‐Garcia Henry , Patel Samir , Bonney Phillip A. , Hwang Lindsay , Yu Cheng , Zada Gabriel , Mathieu David , Trudel Claire , Prasad Rahul N. , Palmer Joshua D. , Jones Brianna M. , Sharma Sonam , Fakhoury Kareem R. , Rusthoven Chad G. , Deibert Christopher P. , Picozzi Piero , Franzini Andrea , Attuati Luca , Lee Cheng‐Chia , Yang Huai‐Che , Ahluwalia Manmeet S. , Sheehan Jason P. , Trifiletti Daniel M. 
Published: January 2022

BACKGROUNDPatients with renal cell carcinoma (RCC) brain metastases are frequently treated with immune checkpoint inhibitors (ICIs) and stereotactic radiosurgery (SRS). However, data reporting on the risk of developing radiation necrosis (RN) are limited.METHODSRN rates were compared for concurrent therapy (ICI/SRS administration within 4 weeks of one another) and nonconcurrent therapy with the χ2 test. Univariable logistic regression was used to identify factors associated with developing RN.RESULTSFifty patients (23 concurrent and 27 nonconcurrent) with 395 brain metastases were analyzed. The median follow‐up was 12.1 months; the median age was 65 years. The median margin dose was 20 Gy, and 4% underwent prior whole‐brain radiation therapy (WBRT). The median treated tumor volume was 3.32 cm3 (range, 0.06‐42.38 cm3); the median volume of normal brain tissue receiving a dose of 12 Gy or higher (V12 Gy) was 8.42 cm3 (range, 0.27‐111.22 cm3). Any‐grade RN occurred in 17.4% and 22.2% in the concurrent and nonconcurrent groups, respectively (P = .67). Symptomatic RN occurred in 4.3% and 14.8% in the concurrent and nonconcurrent groups, respectively (P = .23). Increased tumor volume during SRS (odds ratio [OR], 1.08; 95% confidence interval [CI], 1.01‐1.19; P = .04) was associated with developing RN, although V12 Gy (OR, 1.03; 95% CI, 0.99‐1.06; P = .06), concurrent therapy (OR, 0.74; 95% CI, 0.17‐2.30; P = .76), prior WBRT, and ICI agents were not statistically significant.CONCLUSIONSSymptomatic RN occurs in a minority of patients with RCC brain metastases treated with ICI/SRS. The majority of events were grade 1 to 3 and were managed medically. Concurrent ICI/SRS does not appear to increase this risk. Attempts to improve dose conformality (reduce V12) may be the most successful mitigation strategy in single‐fraction SRS.
The impact of intestinal microbiota in antithymocyte globulin–based myeloablative allogeneic hematopoietic cell transplantation
Authors: Gu Zhenyang , Xiong Qian , Wang Lu , Wang Lili , Li Fei , Hou Cheng , Dou Liping , Zhu Baoli , Liu Daihong 
Published: January 2022

BACKGROUNDThe correlation between intestinal microbiota and clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo‐HCT) has been reported in platforms with T‐cell depletion or postcyclophosphamide‐based graft‐vs‐host disease (GVHD) prophylaxis regimens. It is still unclear whether it is the same in platforms of antithymocyte globulin (ATG)–based myeloablative allo‐HCT.METHODSA total of 603 fecal specimens from 100 consecutive patients receiving allo‐HCT were collected between December 2018 and July 2020. Fetal samples were profiled with next‐generation sequencing of bacterial 16S ribosomal RNA (rRNA) genes.RESULTSThe diversity decreased to the lowest level at approximately day 12 after allo‐HCT and then increased over time. According to the diversity of 314 samples that were collected from 86 patients during the engraftment period, patients were grouped into the low‐ and high‐diversity groups. Two‐year overall survival in the high‐diversity group was significantly longer than that in the low‐diversity group (83.7% vs 60.6%, P = .026). Further analysis revealed that worse outcomes for patients with low diversity were associated with increased risk of worse outcomes for patients with low diversity (adjusted hazard ratio, 4.95; P = .046). Its association with relapse and GVHD was not found. Compositional analysis of fecal microbiota revealed that the abundance of bacteroides decreased greatly during allo‐HCT, whereas that of Enterococcus, Klebsiella, and Escherichia was found to be increased.CONCLUSIONSThis study indicates that gut dysbiosis in platforms of ATG‐based myeloablative allo‐HCT featured loss of bacterial diversity. The diversity of the intestinal flora at the engraftment period was an independent predictor of longer survival.LAY SUMMARY

The correlation between intestinal microbiota and clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo‐HCT) is reported in platforms with T‐cell depletion or postcyclophosphamide‐based graft‐vs‐host disease (GVHD) prophylaxis regimens.

It is still unclear whether it is the same pattern in platforms of antithymocyte globulin (ATG)–based T‐cell repletion myeloablative allo‐HCT.

Our study indicated that gut dysbiosis in platforms of ATG‐based myeloablative allo‐HCT also features loss of bacterial diversity. The diversity of the intestinal flora at the engraftment period is an independent predictor of longer survival.