bluuebunny/crossref_metadata_2025_split huggingface dataset:
Branding Berbasis Digital Content Kopi Arabica Tanah Karo Dan Peningkatan Produktifitas Untuk Hilirisasi Industri Kopi Desa Lingga Kecamatan Kaban Jahe Sumatera Utara
Authors: Destiadi Rezha , Chan Andi Supriadi , Tumanggor Orli Binta 
Published: February 2022

Desa lingga di kabupaten karo merupakan salah satu desa yang menjadi penghasil kopi arabica di sumatera utara. Dilihat dari letak desa lingga yang berada pada dataran tinggi maka jenis tanah disini adalah tanah lembab sehingga tanaman yang ada didominasi oleh pertanian seperti kopi , jeruk dan usaha mikro lainnya yang memiliki Potensi untuk di kembangkan.salah satunya adalah UMKM yang bergerak di pengolahan kopi. Usaha ini dikelola oleh beberapa orang dan memanfaatkan masyarakat sekitar sebagai karyawan. Beberapa permasalahan yang dihadapi oleh kelompok produktif ini seperti pemasaran yang bersifat konvensional dan manajemen pengolahan belum baik dan peralatan produksi dengan kapasitas minim. Tujuan pengabdian kepada masyarakat yang dilakukan oleh Tim Pengabdi ini untuk menyelesaiakan permasalahan yang dihadapi oleh mitra Maju dengan penerapan Iptek yang dibuat untuk menyelesaikan permasalahan dengan cara pelatihan digital content untuk pemasaran dan penjualan menggunakan foto dan video, pelatihan pengolahan proses kopi dengan standatr tinggi serta penyediaan alat giling kopi untuk menjaga mutu dan kualitas produk. Iptek yang akan di implementasikan pada mitra produktif yang berada di desa lingga adalah mesin giling kopi untuk produksi. Kemudian pelatihan digital content berbasis foto dan video, penyediaan website untuk promosi dan penjualan serta pelatihan pengolahan pasca panen kepada petani yang dimiliki agar dapat berkembang menjadi lebih baik dan mandiri. Metode yang digunakan pada kegiatan ini adalah pemberdayaan masyarakat dengan konsep berbasis masyarakat kelompok produktif (Community base Education)
Brain Regeneration Resembles Brain Cancer at Its Early Wound Healing Stage and Diverges From Cancer Later at Its Proliferation and Differentiation Stages
Authors: Demirci Yeliz , Heger Guillaume , Katkat Esra , Papatheodorou Irene , Brazma Alvis , Ozhan Gunes 
Published: February 2022

Gliomas are the most frequent type of brain cancers and characterized by continuous proliferation, inflammation, angiogenesis, invasion and dedifferentiation, which are also among the initiator and sustaining factors of brain regeneration during restoration of tissue integrity and function. Thus, brain regeneration and brain cancer should share more molecular mechanisms at early stages of regeneration where cell proliferation dominates. However, the mechanisms could diverge later when the regenerative response terminates, while cancer cells sustain proliferation. To test this hypothesis, we exploited the adult zebrafish that, in contrast to the mammals, can efficiently regenerate the brain in response to injury. By comparing transcriptome profiles of the regenerating zebrafish telencephalon at its three different stages, i.e., 1 day post-lesion (dpl)-early wound healing stage, 3 dpl-early proliferative stage and 14 dpl-differentiation stage, to those of two brain cancers, i.e., low-grade glioma (LGG) and glioblastoma (GBM), we reveal the common and distinct molecular mechanisms of brain regeneration and brain cancer. While the transcriptomes of 1 dpl and 3 dpl harbor unique gene modules and gene expression profiles that are more divergent from the control, the transcriptome of 14 dpl converges to that of the control. Next, by functional analysis of the transcriptomes of brain regeneration stages to LGG and GBM, we reveal the common and distinct molecular pathways in regeneration and cancer. 1 dpl and LGG and GBM resemble with regard to signaling pathways related to metabolism and neurogenesis, while 3 dpl and LGG and GBM share pathways that control cell proliferation and differentiation. On the other hand, 14 dpl and LGG and GBM converge with respect to developmental and morphogenetic processes. Finally, our global comparison of gene expression profiles of three brain regeneration stages, LGG and GBM exhibit that 1 dpl is the most similar stage to LGG and GBM while 14 dpl is the most distant stage to both brain cancers. Therefore, early convergence and later divergence of brain regeneration and brain cancer constitutes a key starting point in comparative understanding of cellular and molecular events between the two phenomena and development of relevant targeted therapies for brain cancers.
Energy-Saving Synthesis of Functional CoS2/rGO Interlayer With Enhanced Conversion Kinetics for High-Performance Lithium-Sulfur Batteries
Authors: Feng Junan , Li Yahui , Yuan Jinshi , Zhao Yuling , Zhang Jianmin , Wang Fengyun , Tang Jie , Song Jianjun 
Published: February 2022

Lithium sulfur (Li-S) battery has exhibited great application potential in next-generation high-density secondary battery systems due to their excellent energy density and high specific capacity. However, the practical industrialization of Li-S battery is still affected by the low conductivity of sulfur and its discharge product (Li2S2/Li2S), the shuttle effect of lithium polysulfide (Li2Sn, 4 ≤ n ≤ 8) during charging/discharging process and so on. Here, cobalt disulfide/reduced graphene oxide (CoS2/rGO) composites were easily and efficiently prepared through an energy-saving microwave-assisted hydrothermal method and employed as functional interlayer on commercial polypropylene separator to enhance the electrochemical performance of Li-S battery. As a physical barrier and second current collector, the porous conductive rGO can relieve the shuttle effect of polysulfides and ensure fast electron/ion transfer. Polar CoS2 nanoparticles uniformly distributed on rGO provide strong chemical adsorption to capture polysulfides. Benefitting from the synergy of physical and chemical constraints on polysulfides, the Li-S battery with CoS2/rGO functional separator exhibits enhanced conversion kinetics and excellent electrochemical performance with a high cycling initial capacity of 1,122.3 mAh g−1 at 0.2 C, good rate capabilities with 583.9 mAh g−1 at 2 C, and long-term cycle stability (decay rate of 0.08% per cycle at 0.5 C). This work provides an efficient and energy/time-saving microwave hydrothermal method for the synthesis of functional materials in stable Li-S battery.
First-Principles Study on the Half-Metallicity of New MXene Materials Nd2NT2 (T = OH, O, S, F, Cl, and Br)
Authors: Yang Kun , Ren Shuning , Huang Haishen , Wu Bo , Shen Guangxian , Zhou Tingyan , Liu Xiaoying 
Published: February 2022

This work systematically studied the structure, magnetic and electronic properties of the MXene materials Nd2N and Nd2NT2 (T = OH, O, S, F, Cl, and Br) via first-principles calculations based on density functional theory. Results showed that Nd2NT2 (T = OH, O, S, F, Cl, and Br) have half-metallic characteristics whose half-metallic band gap width is higher than 1.70 eV. Its working function ranges from 1.83 to 6.50 eV. The effects of strain on its magnetic and electronic structures were evaluated. Results showed that the structure of Nd2NT2 (T = OH, O, S, and Br) transitions from a ferromagnetic half-metallic semiconductor to a ferromagnetic metallic and ferromagnetic semiconductor under different strains. By contrast, the structures of Nd2NF2 and Nd2NS2 were observed to transition from a half-metallic semiconductor to a ferromagnetic metallic semiconductor under different strains. Calculations of the electronic properties of different proportions of the surface functional groups of Nd2NTx (T = OH, O, and F; x = 0.5, 1(I, II), and 1.5) revealed that Nd2NO1.5 has the characteristics of semiconductors, whereas Nd2NO(II) possesses the characteristics of half-metallic semiconductors. The other structures were observed to exhibit the characteristics of metallic semiconductors. Prediction of Nd2NT2 (T = OH, O, S, F, Cl, and Br) increases the types of lanthanide MXene materials. They are appropriate candidate materials for preparing spintronic devices.
Boosting the Electrochemical Performance of PI-5-CA/C-SWCNT Nanohybrid for Sensitive Detection of E. coli O157:H7 From the Real Sample
Authors: Wang Huan , Fan Yanmiao , Yang Qiaoli , Sun Xiaoyu , Liu Hao , Chen Wei , Aziz Ayesha , Wang Shenqi 
Published: February 2022

Redox activity is an important indicator for evaluating electrochemical biosensors. In this work, we have successfully polymerized indole-5-carboxylic acid into poly-5-carboxyindole nanomaterials (PI-5-CA), using its superior redox activity, and introduced carboxylated single-walled carbon nanotubes (C-SWCNTs) to synthesize a composite material. Finally, a synthesized composite material was used for the modification of the glass carbon electrode to fabricate the PI-5-CA/C-SWCNTs/GCE-based immunosensor and was successfully applied for the sensitive detection of E. coli O157:H7. The fabricated immunosensor exhibited an outstanding electrocatalytic activity toward the detection of E. coli O157:H7 with a remarkably lowest limit of detection (2.5 CFU/ml, LOD = 3 SD/k, n = 3) and has a wide linear range from 2.98×101 to 2.98×107 CFU/ml. Inspired from the excellent results, the fabricated electrode was applied for the detection of bacteria from real samples (water samples) with a good recovery rate (98.13–107.69%) as well as an excellent stability and specificity. Owing to its simple preparation, excellent performance, and detection time within 30 min, our proposed immunosensor will open a new horizon in different fields for the sensitive detection of bacteria from real samples.
Combined Lifestyle Factors and Risk of All-Cause and Cause-Specific Mortality Among Participants in the Linxian Nutrition Intervention Trial: A Cohort, Observational Study
Authors: Fan Jin-hu , Wang Jian-bing , Yang Huan , Dawsey Sanford M. , Taylor Philip R. , Qiao You-lin , Abnet Christian C. 
Published: February 2022

BackgroundSeveral studies have indicated that combinations of lifestyle and dietary factors are associated with risk of total mortality and death from cardiovascular disease and cancer, but limited data are available from long-term follow-up studies in China.MethodsThis study was a observational cohort study. We prospectively examined the associations of combined lifestyle factors and risk of total and cause-specific mortality in the Linxian General Population Nutrition Intervention Trial (NIT) cohort that included 29,584 healthy adults. A points system method was used to calculate a combined risk score of five lifestyle factors, including smoking, alcohol drinking, body mass index, vegetable intake and fruit intake. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs).ResultsOverall, adjusted hazard ratios for mortality increased progressively with an increasing combined risk score. Compared to individuals with a score of zero or one, HRs (95%CIs) for a score of five or above were 1.59 (1.44–1.75) for all-cause mortality, 1.67 (1.48–1.88) for heart disease, 1.69 (1.52–1.88) for stroke, and 1.34 (1.21, 1.47) for cancer. This association for mortality was seen consistently, regardless of gender and age at baseline.ConclusionsA higher combined risk score was positively associated with risk of total, heart disease, stroke, and cancer mortality. These findings could provide further evidence for the idea that healthy lifestyle is the optimal way to reduce the risk of premature death, and encourage behavior change.
Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts
Authors: Vekstein Andrew M. , Wendell David C. , DeLuca Sophia , Yan Ruorong , Chen Yifan , Bishawi Muath , Devlin Garth W. , Asokan Aravind , Poss Kenneth D. , Bowles Dawn E. , Williams Adam R. , Bursac Nenad 
Published: February 2022

BackgroundThe optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus compared targeted IM against less invasive, catheter-based intra-coronary (IC) delivery to porcine myocardium for the acute retention of nanoparticles using cardiac magnetic resonance (CMR) imaging and viral vector transduction using qPCR.MethodsFerumoxytol iron oxide (IO) nanoparticles (5 ml) were administered to Yorkshire swine (n = 13) by: (1) IM via thoracotomy, (2) catheter-based IC balloon-occlusion (BO) with infusion into the distal left anterior descending (LAD) coronary artery, (3) IC perforated side-wall (SW) infusion into the LAD, or (4) non-selective IC via left main (LM) coronary artery infusion. Hearts were harvested and imaged using at 3T whole-body MRI scanner. In separate Yorkshire swine (n = 13), an adeno-associated virus (AAV) vector was similarly delivered, tissue harvested 4–6 weeks later, and viral DNA quantified from predefined areas at risk (apical LV/RV) vs. not at risk in a potential mid-LAD infarct model. Results were analyzed using pairwise Student's t-test.ResultsIM delivery yielded the highest IO retention (16.0 ± 4.6% of left ventricular volume). Of the IC approaches, BO showed the highest IO retention (8.7 ± 2.2% vs. SW = 5.5 ± 4.9% and LM = 0%) and yielded consistent uptake in the porcine distal LAD territory, including the apical septum, LV, and RV. IM delivery was limited to the apex and anterior wall, without septal retention. For the AAV delivery, the BO was most efficient in the at risk territory (Risk: BO = 6.0 × 10−9, IM = 1.4 × 10−9, LM = 3.2 × 10−10 viral copies per μg genomic DNA) while all delivery routes were comparable in the non-risk territory (BO = 1.7 × 10−9, IM = 8.9 × 10−10, LM = 1.2 × 10−9).ConclusionsDirect IM injection has the highest local retention, while IC delivery with balloon occlusion and distal infusion is the most effective IC delivery technique to target therapeutics to a heart territory most in risk from an infarct.
Generational Perspectives on Technology's Role in Mental Health Care: A Survey of Adults With Lived Mental Health Experience
Authors: Woerner Molly , Sams Nichole , Rivera Nales Cristian , Gorstein Tara , Johnson Morgan , Mosser Brittany A. , Areán Patricia A. 
Published: February 2022

IntroductionPersonal technology (e.g., smartphones, wearable health devices) has been leveraged extensively for mental health purposes, with upwards of 20,000 mobile applications on the market today and has been considered an important implementation strategy to overcome barriers many people face in accessing mental health care. The main question yet to be addressed is the role consumers feel technology should play in their care. One underserved demographic often ignored in this discussion are people over the age of 60. The population of adults 60 and older is predicted to double by 2,050 signaling a need to address how older adults view technology for their mental health care.ObjectiveThe objective of this study is to better understand why digital mental health tools are not as broadly adopted as predicted, what role people with lived mental health experience feel technology should play in their care and how those results compare across age groups.MethodIn a mixed-methods approach, we analyzed results from a one-time cross-sectional survey that included 998 adults aged 18–83 with lived experience of mental health concerns recruited from Prolific, an online research platform. We surveyed participant's use of technology including their perspectives on using technology in conjunction with their mental health care. We asked participants about their previous use of digital mental health tools, their treatment preferences for mental health care, and the role technology should play in their mental health care.ResultsAcross all age groups, respondents had favorable views of using digital mental health for managing mental health care. However, older adults rated their acceptability of digital mental health tools lower than middle-aged and younger adults. When asked what role technology should play in mental health care in an open-ended response, most participants responded that technology should play a complementary role in mental health care (723/954, 75.8%).ConclusionDigital mental health is seen as a valuable care management tool across all age groups, but preferences for its role in care remain largely administrative and supportive. Future development of digital mental health should reflect these preferences.
The Huapinghsu Channel/Mienhua Canyon System as a Sediment Conduit Transporting Sediments From Offshore North Taiwan to the Southern Okinawa Trough
Authors: Chiang Cheng-Shing , Yu Ho-Shing , Noda Atsushi , TuZino Taqumi 
Published: February 2022

By examining bathymetric and seismic reflection data in the shelf-slope region offshore northeast of Taiwan, the morphology of the Huapinghsu Channel/Mienhua Canyon System was refined and the occurrence of axial incision in the major erosional trough of the Mienhua Canyon was identified. The Huapinghsu Channel extends from its head at a water depth of 120 m seaward across the shelf-slope region and merges with the Mienhua Canyon before finally emptying into the Southern Okinawa Trough. This review with a new idea illustrates this channel/canyon system as a sediment conduit transporting sediments from western Taiwan rivers to the Southern Okinawa Trough. Within the proximal reach of the Mienhua Canyon, in situ suspended particles were found associated with bottom nepheloid layers, which transport resuspended particles along the canyon course, and eventually into the Southern Okinawa Trough even during sea-level highstand. The shelf area around the channel head is subject to the influence of frequent occurrences of large typhoons and seasonal migrations of oceanic currents. Numerical examinations indicate that the flow velocities related with large waves or currents satisfy the critical values to the threshold of the motion of fine sand, implying gravity flows occur around the channel head, sweep unconsolidated sediments in the channel head, or even incise the channel floor at the present day. In this paper, sea level changes from the Last Glacial Maximum (LGM, ∼21 ka BP) to the present and sediment input to the head of the Huapinghsu Channel head are considered the major factors in the control of the Huapinghsu Channel/Mienhua Canyon system, which functions as a sediment conduit in the study area. Tectonics and climate are the minor factors that contribute to shelf sediment transport to the Southern Okinawa Trough via this channel/canyon system.
The Early Cretaceous Zaduo Granite, Eastern Qiangtang Terrane (China)—An Attempt to Constrain its Paleolatitude and Tectonic Implications
Authors: Fu Qiang , Yan Maodu , Dekkers Mark J. , Guan Chong , de Boer Rosa A. , Yu Liang , Xu Wanlong , Li Bingshuai , Shen Miaomiao , Zhang Jingyu , Xu Zunbo 
Published: February 2022

The Eastern Qiangtang Terrane is an orogenic-like belt around the Eastern Himalayan syntaxis (EHS). The deformation history of this terrane must be known to understand how the EHS region responded to the Lhasa-Qiangtang collision and the closure of the Bangong-Nujiang Ocean (BNO). Here, we present a new paleomagnetic investigation on an Early Cretaceous granite (∼126 Ma) in the Zaduo area, Eastern Qiangtang Terrane. Petrographic observations reflect crystallization from primary melts with only limited subsequent alteration (chloritization of biotite). Magnetite appears to be the dominant carrier of the characteristic remanent magnetization (ChRM) based on stepwise demagnetization of the natural remanent magnetization, supplemented by detailed rock magnetic measurements, including magnetization versus temperature, and acquisition curves of the isothermal and anhysteretic remanent magnetization. End-member modeling of those acquisition curves helped to constrain the paleomagnetic analysis. The inconsistent demagnetization behavior between alternating field (AF) demagnetization at high levels and thermal demagnetization was attributed to the development of gyroremanent magnetization in the AF demagnetization generated by fine-grained single domain magnetite. The ChRM directions from 92 granite samples in geographic coordinates yield an average of declination (Dg) of 2.6° and inclination (Ig) of 38.6° (precision parameter k = 51.4, and 95% confidence cone α95 = 2.1°). The amount of tilting of the granite is poorly constrained which makes proper correction rather tedious. We compared the expected bedding attitudes (Strikeexp = 43.1°, Dipexp = 46.1°) derived from published data (Huang et al., 1992;Tong et al., 2015) with the average observed bedding attitudes (Strikeobs = 54°, Dipobs = 32°) of the Middle-Upper Jurassic sandstones of the Yanshiping Group that was intruded by the Early Cretaceous granite. The discrepancy between the expected and measured bedding attitudes implies that the strata of the Yanshiping Group in the Zaduo area were already tilted prior to the intrusion of the ∼126 Ma Zaduo granite, which was attributed to the Lhasa-Qiangtang collision and the closure of the BNO. The collision led to a series of geological events, such as the tilting of the strata, the ophiolite emplacement, the development of a peripheral foreland basin, and the magmatic activity gap. The tilting/folding of the strata was generally delayed by the layer parallel shortening processes during the early stages of the deformation, thus suggesting an older Lhasa-Qiangtang collision (i.e., &gt;126 Ma).
A Surgeon-Centered Neuromuscular Block Protocol Improving Intraoperative Neuromonitoring Outcome of Thyroid Surgery
Authors: Lu I-Cheng , Hsu Chiung-Dan , Chang Pi-Ying , Wu Sheng-Hua , Huang Tzu-Yen , Lin Yi-Chu , Ko How-Yun , Dionigi Gianlorenzo , Chai Young Jun , Chiang Feng-Yu , Kuo Yi-Wei , Wu Che-Wei 
Published: February 2022

BackgroundNeuromuscular blocking agents provide muscular relaxation for tracheal intubation and surgery. However, the degree of neuromuscular block may disturb neuromuscular transmission and lead to weak electromyography during intraoperative neuromonitoring. This study aimed to investigate a surgeon-friendly neuromuscular block degree titrated sugammadex protocol to maintain both intraoperative neuromonitoring quality and surgical relaxation during thyroid surgery.MethodsA total of 116 patients were enrolled into two groups and underwent elective thyroid surgery with intraoperative neuromonitoring. All patients followed a standardized intraoperative neuromonitoring protocol with continuous neuromuscular transmission monitoring and received 0.6 mg/kg rocuronium for tracheal intubation. Patients were allocated into two groups according to the degree of neuromuscular block when the anterior surface of the thyroid gland was exposed. The neuromuscular block degree was assessed by the train-of-four (TOF) count and ratio. Patients in group I received sugammadex 0.25 mg/kg for non-deep neuromuscular block degree (TOF count = 1~4). Patients in group II were administered sugammadex 0.5 mg/kg for deep neuromuscular block degree (TOF count = 0). The quality of the intraoperative neuromonitoring was measured using the V1 electromyography (EMG) amplitude. An amplitude less than 500 μV and greater than 500 μV was defined as weak and satisfactory, respectively.ResultsThe quality of the intraoperative neuromonitoring was not different between groups I and II (satisfactory/weak: 75/1 vs. 38/2, P = 0.14). The quality of surgical relaxation was acceptable after sugammadex injection and showed no difference between groups [55/76 (72.3%) in group I vs. 33/40 (82.5%) in group II, P = 0.23].ConclusionsThis surgeon-centered sugammadex protocol guided by neuromuscular block degree (0.5 mg/kg for deep block and 0.25 mg/kg for others) showed comparably high intraoperative neuromonitoring quality and adequate surgical relaxation. The results expanded the practicality of sugammadex for precise neuromuscular block management during monitored thyroidectomy.