bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing research into the social psychology of sexual orientations and gender identities: Current research and future directions
Authors: Salvati Marco , Koc Yasin 
Published: June 2022

AbstractOver the past decades, LGBTQ+ issues have been at the centre of politics, social movements, and human rights discussions across the world. Consistent with these developments, there is a growing interest in social psychological research into sexual orientation and gender identities. The emerging research not only taps recent societal developments and the effects of these on LGBTQ+ people; but also focuses on very old research questions of stereotypes and prejudice that are still relevant today. In this special issue, we bring together nine papers addressing several of these issues using qualitative, correlational, and experimental methods with sexual majority and minority samples across different cultural contexts. We discuss the current state of the field and how further research could enhance our understanding of LGBTQ+ issues.
Analyzing interactive call, default, and conversion policies for corporate bonds
Authors: Liu Liang‐Chih , Dai Tian‐Shyr , Zhou Lei , Chang Hao‐Han 
Published: June 2022

AbstractThis paper studies the timings of interactive call and conversion decisions made by bond issuers and holders, respectively, due to the presence of different embedded options. We develop a risk‐neutral‐valuation‐based game option model featuring bondholder–stockholder conflicts of interest. The presence of conversion (call) options possessed by the bondholders (issuers) accelerates the call (conversion) decisions. Granting bondholders additional put options further hastens call decisions and hence conversion decisions in response to call accelerations. Our empirical studies are consistent with past call policy research and support our interactive exercise analyses that explain the rationales behind early call and conversion phenomena.
Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B
Authors: Xu Cong , Fan Jieqing , Liu Danyang , Tuerdi Aimaier , Chen Juanjuan , Wei Yuning , Pan Yanfang , Dang Huaixin , Wei Xiong , Yousif Ashraf Siddig , Yogaratnam Jeysen , Zhou Qiong , Lichenstein Henri , Xu Tian 
Published: June 2022

Background and Aims:
In the treatment of chronic hepatitis B (CHB) infection, stimulation of innate immunity may lead to hepatitis B virus (HBV) cure. Alpha‐kinase 1 (ALPK1) is a pattern recognition receptor (PRR) that activates the NF‐κB pathway and stimulates innate immunity. Here we characterized the preclinical anti‐HBV efficacy of DF‐006, an orally active agonist of ALPK1 currently in clinical development for CHB.

Approach and Results:
In adeno‐associated virus (AAV)‐HBV mouse models and primary human hepatocytes (PHHs) infected with HBV, we evaluated the antiviral efficacy of DF‐006. In the mouse models, DF‐006 rapidly reduced serum HBV DNA, hepatitis B surface antigen, and hepatitis B e antigen levels using doses as low as 0.08 μg/kg, 1 μg/kg, and 5 μg/kg, respectively. DF‐006 in combination with the HBV nucleoside reverse transcriptase inhibitor, entecavir, further reduced HBV DNA. Antiviral efficacy in mice was associated with an increase in immune cell infiltration and decrease of hepatitis B core antigen, encapsidated pregenomic RNA, and covalently closed circular DNA in liver. At subnanomolar concentrations, DF‐006 also showed anti‐HBV efficacy in PHH with significant reductions of HBV DNA. Following dosing with DF‐006, there was upregulation of NF‐κB‐targeted genes that are involved in innate immunity.

Conclusion:
DF‐006 was efficacious in mouse and PHH models of HBV without any indications of overt toxicity. In mice, DF‐006 localized primarily to the liver where it potently activated innate immunity. The transcriptional response in mouse liver provides insights into mechanisms that mediate anti‐HBV efficacy by DF‐006.
Exploring resting frontal EEG and reflective functioning in maternal substance use
Authors: Ngoh Gwendolyn , Wu Jia , Potenza Marc N. , Mayes Linda C. , Rutherford Helena J. V. 
Published: June 2022

AbstractMaternal substance use is associated with altered neural activity and poor offspring outcomes, which may be facilitated by suboptimal caregiving in the form of impaired parental reflective functioning (PRF). To investigate these associations, the resting‐state frontal electroencephalography (EEG) power of 48 substance‐using mothers and 37 non‐substance‐using mothers were examined, specifying seven frequency bands: delta, theta, alpha, alpha1, alpha2, beta, and gamma. Substance‐using mothers exhibited enhanced beta and gamma spectral power compared to non‐substance‐using mothers, potentially reflecting higher arousal states in substance‐using mothers. There were no between‐group differences in any component of PRF (i.e., levels of pre‐mentalizing, certainty, and interest and curiosity). Whole‐sample analyses revealed significant positive correlations between pre‐mentalizing and delta spectral power. Taken together, these findings suggest potential neural correlates of maternal substance use and PRF, providing an important next step into examining associations between maternal substance use and poor child outcomes.
Low‐dose rapamycin prevents Ang‐II‐induced toxicity in Leydig cells and testicular dysfunction in hypertensive SHR model
Authors: Kuo Wei‐Wen , Baskaran Rathinasamy , Lin Jing‐Ying , Day Cecilia Hsuan , Lin Yueh‐Min , Ho Tsung‐Jung , Chen Ray‐Jade , Lin Mei‐Yi , Padma Viswanadha Vijaya , Huang Chih‐Yang 
Published: June 2022

AbstractHypertension is a common chronic cardiovascular disease reported among both men and women. Hypertension in males affects the testis and reproduction function; however, the pathogenesis is poorly understood. Rapamycin has been reported to have a variety of beneficial pharmacological effects; however, high‐doses rapamycin does have side effects such as immunosuppression. The present study investigates whether low‐dose rapamycin can reduce the damage caused by hypertension to the testis of spontaneously hypertensive rats (SHRs) and further examines molecular mechanism of low‐dose rapamycin in preventing testicular toxicity induced by angiotensin II (Ang II). Low rapamycin dose restores the testicle size, histological alterations, 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expression, and prevents apoptosis in SHR rats. Ang II downregulates angiotensin‐converting enzyme‐2 (ACE2) expression through AT1R, p‐ERK, and MAS receptor in LC‐540 Leydig cells in a dose‐dependent manner. Low doses of rapamycin effectively upregulate steroidogenic enzymes, steroidogenic acute regulatory protein and 3β‐HSD expression in Leydig cells. Rapamycin upregulates ACE2 expression through p‐PKAc and p‐PI3k in Ang II‐treated cells. Further, rapamycin curbs mitochondrial superoxide generation and depleted mitochondrial membrane potential induced by Ang II through activation of Nrf2‐mediated Gpx4 and superoxide dismutase 2 expression. Our results revealed the involvement of ACE2, AT1R, AT2R, PKAc, and oxidative stress in Ang‐II‐induced testicular toxicity, suggesting low‐dose rapamycin could be a potential therapeutic candidate to attenuate testicular toxicity.
PARP‐1 modulates the expression of miR‐223 through histone acetylation to involve in the hydroquinone‐induced carcinogenesis of TK6 cells
Authors: Ling Xiaoxuan , Pan Zhijie , Zhang Haiqiao , Wu Minhua , Gui Zhiming , Yuan Qian , Chen Jialong , Peng Jianming , Liu Zhidong , Tan Qiang , Huang Dongsheng , Xiu Liangchang , Liu Linhua 
Published: June 2022

AbstractThe upstream regulators of microRNAs were rarely reported. Hydroquinone (HQ) is the main metabolite of benzene, one of the important environmental factors contributing to leukemia and lymphoma. In HQ‐induced malignant transformed TK6 (TK6‐HT) cells, the expression of PARP‐1 and miR‐223 were upregulated. When in PARP‐1 silencing TK6‐HT cells, miR‐223 was downregulated and the apoptotic cell number correspondingly increased. In TK6 cells treated with HQ for different terms, the expression of miR‐223 and PARP‐1 were dynamically observed and found to be decreased and increased, respectively. Trichostatin A could increase the expression of miR‐223, then the expression of HDAC1–2 and nuclear factor kappa B were found to be increased, but that of mH2A was decreased. PARP‐1 silencing inhibited the protein expression of H3Ac, mH2A, and H3K27ac. By co‐immunoprecipitation experiment, PARP‐1 and HDAC2 were found to form a regulatory complex. In conclusion, we demonstrated that the upregulation of PARP‐1 mediated activation of acetylation to promote the transcription of miR‐223 possibly via coregulating with HDAC2, an epigenetic regulation mechanism involved in cell malignant transformation resulting from long‐term exposure to HQ, in which course, H3K27ac might be a specific marker for the activation of histone H3, which also gives hints for benzene exposure research.
Advancing access to Medicare‐funded mental health treatment during the opioid epidemic: A counselor advocacy analysis
Authors: Westcott Jordan B. , Fullen Matthew C. , Jordan Justin 
Published: June 2022

AbstractAlthough advocacy is a priority for counseling professionals, little is known about counseling advocates’ participation in the legislative advocacy process. Recent legislation to address the opioid crisis allowed counseling advocates to provide public comments to advance counselor inclusion in the Medicare program. A thematic analysis of 548 public comments provided on behalf of the counseling profession yielded four categories: advocacy on behalf of (1) the proposed rule change; (2) broader Medicare inclusion; (3) the proposed rule change with an additional request for broader Medicare reimbursement; and (4) no clear advocacy. Subthemes included increasing access to care, qualifications necessary to provide care, and the urgency of the opioid epidemic, among others. Implications for the counseling profession and counselor advocacy are discussed.
The role of sense of community in improving the health‐related quality of life among Black Americans
Authors: Wippold Guillermo M. , Garcia Kaylyn A. , Frary Sarah Grace 
Published: June 2022

AbstractBlack Americans have the lowest life expectancy and health‐related quality of life (HRQoL; a strong predictor of premature mortality) of any racial/ethnic group in the United States. Low rates of physical activity and engagement in healthy eating are two known contributors to low HRQoL. Black Americans are more likely to live in environments that inhibit engagement in these two contributors. The present study examined sense of community as a buffer against the adverse effects of low physical activity and healthy eating on HRQoL among Black Americans. A sample of 290 Black American adults were recruited for the present study. Results indicate that sense of community buffers against the adverse effects of low physical activity on HRQoL. The results of the present study can be used by health promotion interventionists and policy‐makers to improve HRQoL and reduce premature mortality among Black Americans.
What works? Lessons from a pretrial qualitative study to inform a multi‐component intervention for refugees and asylum seekers: Learning Through Play and EMDR Group Traumatic Episode Protocol
Authors: Kaptan Safa Kemal , Yilmaz Betul , Varese Filippo , Andriopoulou Panoraia , Husain Nusrat 
Published: June 2022

AbstractAlmost half of the trials failed to recruit their targeted sample size of which 89% could be preventable. Successful implementation of mental health trials in a context of forcibly displaced individuals can be even more challenging. Mental health difficulties have the potential to impact parenting skills, which are linked to poor development in children, while parenting interventions can improve parents' mental health and parenting behaviors. However, the evidence on parenting interventions for refugees is limited. A parenting intervention, Learning Through Play Plus Eye Movement Desensitization and Reprocessing Group Treatment Protocol, has been designed to address parental mental health. This pretrial qualitative study, conducted with refugees, asylum seekers and professionals, aimed to explore their perceptions of the intervention and to identify barriers and recommendations for better engagement, recruitment, and delivery. Three themes were generated from thematic analysis: the content of the intervention, suggestions for improvement and implementation, and understanding the role of the facilitator. These themes provided insights into the issues that might predict the barriers for delivery of the intervention and offered several changes, including destigmatization strategies to improve engagement.
3D printed controllable microporous scaffolds support embryonic development in vitro
Authors: Guo Jia , Li Yuanyuan , Gao Zili , Lyu Jiawei , Liu Wenli , Duan Yongchao , Zhou Lixun , Gu Qi 
Published: June 2022

AbstractLittle is known about the complex molecular and cellular events occurring during implantation, which represents a critical step for pregnancy. The conventional 2D culture could not support postimplantation embryos' normal development, and 3D conditions shed light into the “black box”. 3D printing technology has been widely used in recapitulating the structure and function of native tissues in vitro. Here, we 3D printed anisotropic microporous scaffolds to culture embryos by manipulating the advancing angle between printed layers, which affected embryo development. The 30° and 60° scaffolds promote embryo development with moderate embryo‐scaffold attachments. T‐positive cells and FOXA2‐positive cells were observed to appear in the posterior region of the embryo and migrated to the anterior region of the embryo on day 7. These findings demonstrate a 3D printed stand that supports embryonic development in vitro and the critical role of 3D architecture for embryo implantation, in which additive manufacturing is a versatile tool.
COVID‐19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta‐analysis
Authors: Lim Yeong Jer , Khan Umair , Karpha Indrani , Ross Andrew , Saif Muhammad , Remberger Mats , Kalakonda Nagesh , Pettitt Andrew R. , Floisand Yngvar 
Published: June 2022

AbstractUp‐to‐date information on coronavirus disease 2019 (COVID‐19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID‐19 mitigation strategies. We performed a meta‐analysis to address this knowledge gap. All studies with at least five patients who reported COVID‐19‐related deaths in HCT recipients were included. The primary outcome was COVID‐19‐related death. Secondary outcomes were COVID‐19‐related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID‐19‐related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%–24%), while MV and ITU admission rates were 14% (95% CI 11%–17%) and 18% (95% CI 14%–22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID‐19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09–3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38–3.20) or in the context of active graft‐versus‐host disease (RR 2.38, 95% CI 1.10–5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID‐19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID‐19 outcomes.
Convective precipitation over a Mediterranean area: From identification to trend analysis starting from high‐resolution rain gauges data
Authors: Treppiedi Dario , Cipolla Giuseppe , Noto Leonardo Valerio 
Published: June 2022

AbstractHeavy rainfall events are likely to become more frequent and severe in the next future, under the effects of a changing climate. In this context, the scientific literature is characterized by a relevant number of studies trying to identify the convective component of precipitation, since this kind of phenomena, due to their short duration and high intensity, may lead to an increased risk of flash floods or debris flows and, consequently, human life losses and economic damages. In this study, a separation between the convective and stratiform precipitation, starting from the subhourly precipitation time series recorded over Sicily (Italy), is provided on a monthly scale. Results show that the percentage of convective precipitation increases as the associated intensity increases, following what is generally known about convective events. Moreover, during the summer months, higher percentages of convective rainfall are generally reached for lower values of intensity, since this season favours the occurrence of these phenomena due to high temperature and relative humidity. In addition to the regional analysis, even an at‐site analysis has been carried out, through the definition of a critical intensity threshold to identify the predominant convective component for each rain gauge. This analysis has pointed out that such convective events have occurred mainly in the east part of the island mainly due to the complex orography of this area, which favours the occurrence not only of such phenomena but of flash floods and debris flows as well.
The power of sharing meaningful moments: A Buberian analysis of a counseling intervention
Authors: van de Goor Jacky , Sools Anneke M. , Smits Micole M. , Westerhof Gerben J. 
Published: June 2022

Abstract“All real living is meeting”. This study presents an empirical study of the way a sense of meaning‐as‐connectedness is brought about in a group counseling intervention in which meaningful moments are shared. Results from a thematic analysis exemplify and at one point extend Buber's philosophy of meeting.
Ice‐sheet deglaciation and Loch Lomond Readvance in the eastern Cairngorms: implications of a Lateglacial sediment record from Glen Builg
Authors: Carter‐Champion Alice , Abrook Ashley M. , Pike Joshua H. , Matthews Ian P. , Palmer Adrian P. , Lowe J. John 
Published: June 2022

AbstractWe present new lithostratigraphic, pollen‐stratigraphic and tephrochronological data obtained from a sediment sequence in a small lake basin in Glen Builg, eastern Cairngorms, with mapping of the surrounding glacial geomorphological features. The collective evidence indicates that basin organic sediment accumulation started during the Windermere Interstadial at ~14.3 ka. The new results reaffirm the conclusions of Clapperton et al. (1975), that any occupation of the eastern Cairngorms by Loch Lomond (‘Younger Dryas’) Stadial glacier ice was spatially restricted. The record also suggests that harsh climatic conditions prevailed throughout the Windermere Interstadial, probably due to the relatively high altitude of the site (~460 m) and its proximity to major Cairngorm peaks. Our new, more comprehensive study provides a robust chronology, and reveals several palaeoenvironmental signals congruent with other recently reported Scottish Highlands records. Key similarities with regional records are: (i) a short climatic reversal corresponding to GI‐1d in the Greenland stratotype sequence; (ii) a two‐phased Loch Lomond Stadial, with a transition around the Vedde Ash, dating to ~12.1 ka; and (iii) a delayed response to Early Holocene climatic warming of ~250 years, before soils were sufficiently stabilised to permit shrub vegetation establishment.
Diagnostic laparoscopy is underutilized in the staging of gastric adenocarcinoma regardless of hospital type: An US safety net collaborative analysis
Authors: Leder Macek Aleeza J. , Wang Annie , Turgeon Michael K. , Lee Rachel M. , Russell Maria C. , Porembka Matthew R. , Alterio Rodrigo , Ju Michelle , Kronenfeld Joshua , Goel Neha , Datta Jashodeep , Maker Ajay V. , Fernandez Manuel , Richter Harry , Berman Russell S. , Correa‐Gallego Camilo , Lee Ann Y. 
Published: June 2022

AbstractBackgroundDiagnostic laparoscopy (DL) is a key component of staging for locally advanced gastric adenocarcinoma (GA). We hypothesized that utilization of DL varied between safety net (SNH) and affiliated tertiary referral centers (TRCs).MethodsPatients diagnosed with primary GA eligible for DL were identified from the US Safety Net Collaborative database (2012–2014). Clinicopathologic factors were analyzed for association with use of DL and findings on DL. Overall survival (OS) was analyzed by Kaplan–Meier method.ResultsAmong 233 eligible patients, 69 (30%) received DL, of which 24 (35%) were positive for metastatic disease. Forty percent of eligible SNH patients underwent DL compared to 21.5% at TRCs. Lack of insurance was significantly associated with decreased use of DL (OR 0.48, p < 0.01), while African American (OR 6.87, p = 0.02) and Asian race (OR 3.12, p ≤ 0.01), signet ring cells on biopsy (OR 3.14, p < 0.01), and distal tumors (OR 1.62, p < 0.01) were associated with increased use. Median OS of patients with a negative DL was better than those without DL or a positive DL (not reached vs. 32 vs. 12 months, p < 0.005, Figure 1).ConclusionsResults from DL are a strong predictor of OS in GA; however, the procedure is underutilized. Patients from racial minority groups were more likely to undergo DL, which likely accounts for higher DL rates among SNH patients.
Patterns of disease relapse and posttreatment follow‐up of patients with resected pancreatic adenocarcinoma: A single‐center analysis
Authors: Gonzales Beatriz A. , Diniz Alessandro L. , Torres Silvio M. , Salvador de Castro Ribeiro Héber , Correia de Farias Igor , Luís de Godoy André , Coimbra Felipe J. F. , Fonseca de Jesus Victor H. 
Published: June 2022

AbstractBackground and ObjectivesTo describe the patterns of disease relapse and follow‐up of patients with resected pancreatic adenocarcinoma. Additionally, we looked at patients' characteristics at relapse and survival.MethodsWe included patients with potentially resectable pancreatic adenocarcinoma diagnosed from 2008 to 2018 who were submitted to resection with clear macroscopic margins and started posttreatment surveillance.ResultsThe study population consists of 73 patients. The median interval between imaging studies was 3.2 months during the first 2 years of follow‐up and 5.1 months thereafter. Forty‐eight patients (65.8%) experienced disease relapse. The most frequent single site of relapse was locoregional (N = 21; 43.8%). At relapse, 31 patients (64.6%) were symptomatic and forty‐two patients (87.6%) had Eastern Cooperative Oncology Group performance status 0 or 1. Most patients were able to undergo additional anticancer therapy (N = 41; 85.4%). Patients with asymptomatic relapses experienced longer median postrelapse survival (25.4 vs. 11.3 months; p = 0.015).ConclusionsA follow‐up protocol that included imaging studies every 3 months in the first 2 years and every 6 months thereafter is able to diagnose disease relapse when patients have adequate performance status and are still able to undergo additional anticancer treatment.