bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near‐Infrared Aggregation‐Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease
Authors: Zhang Tianfu , Chen Xiaoyu , Yuan Congmin , Pang Xiaobin , Shangguan Ping , Liu Yisheng , Han Lulu , Sun Jianwei , Lam Jacky W. Y. , Liu Yang , Wang Jiefei , Shi Bingyang , Zhong Tang Ben 
Published: November 2022

AbstractOptimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis encounter failures due to the blood–brain barrier (BBB) penetration challenge and blind intervention time window. Herein, we design a near‐infrared (NIR) aggregation‐induced emission (AIE) probe, DNTPH, via balanced hydrophobicity‐hydrophilicity strategy. DNTPH binds selectively to Aβ fibrils with a high signal‐to‐noise ratio. In vivo imaging revealed its excellent BBB permeability and long‐term tracking ability with high‐performance AD diagnosis. Remarkably, DNTPH exhibits a strong inhibitory effect on Aβ fibrosis and promotes fibril disassembly, thereby attenuating Aβ‐induced neurotoxicity. DNTPH treatment significantly reduced Aβ plaques and rescued learning deficits in AD mice. Thus, DNTPH serves as the first AIE in vivo theranostic agent for real‐time NIR imaging of Aβ plaques and AD therapy simultaneously.
Formyl Radical Generation from α‐Chloro N‐Methoxyphthalimides Enables Selective Aldehyde Synthesis
Authors: Liu Dan , Yang Kai , Fang Di , Li Shi‐Jun , Lan Yu , Chen Yiyun 
Published: November 2022

AbstractThe aldehydes installation by radical formylation constitutes an attractive synthetic strategy. However, the generation of formyl radicals for organic synthesis applications remains unknown. Herein we report the first formyl radical generation from α‐chloro N‐methoxyphthalimides, which selectively synthesize aldehydes by alkene hydroformylation under mild photoredox conditions. The aldehydes can be installed on acrylates, acrylamides, vinyl sulfones, vinyl ketones, and complex steroids by radical hydroformylation in excellent chemoselectivity and regioselectivity. The concerted hydrochloride elimination for the formyl radical generation from α‐chloro methoxy radicals is established by experimental and computational approaches.
A High‐Performance Nonlinear Optical Crystal with a Building Block Containing Expanded π‐Delocalization
Authors: Li Yanqiang , Huang Weiqi , Zhou Yang , Song Xianyu , Zheng Jieyu , Wang Han , Song Yipeng , Li Minjuan , Luo Junhua , Zhao Sangen 
Published: November 2022

AbstractCommon nonlinear optical (NLO) crystals consist of traditional functional building blocks with inherent optical limitation. Herein, inspired by traditional (B3O6)3− inorganic building block, we theoretically identified a new type of organic functional building blocks and then successfully synthesized the first cyamelurate NLO crystal, Ba(H2C6N7O3)2 ⋅ 8 H2O. To our surprise, the constituent (H2C6N7O3)− building block is not in structurally optimal arrangement, but Ba(H2C6N7O3)2 ⋅ 8 H2O exhibits excellent optical properties including wide band gap of 4.10 eV, very large birefringence of 0.24@550 nm, and exceptionally strong second‐harmonic generation (SHG) response of about 12×KH2PO4. Both the SHG response and birefringence are much larger than those of commercial NLO crystal β‐BaB2O4 with optimally aligned (B3O6)3− building block. Theoretical calculations suggest that the expanded π‐conjugation delocalization within (H2C6N7O3)− vs (B3O6)3− should be responsible to the enhanced performance. This work implies that there is still much room to develop new NLO crystals with excellent functional building blocks that may be longly neglected.
A monomolecular organophosphate for enhancing the flame retardancy, thermostability and crystallization properties of polylactic acid
Authors: Liu Lubin , Yan Chentao , Zhang Wenjia , Xu Yue , Xu Miaojun , Hong Yukai , Qiu Yong , Li Bin 
Published: November 2022

AbstractPolylactic acid (PLA) is regarded as one of the most promising bioplastics. However, its inherent high flammability of PLA seriously limits its application in the emerging fields. Although the traditional phosphate flame retardants showed excellent flame retardant efficiency in PLA, they often failed to meet the processing requirements of PLA and the thermal stability of PLA composites was decreased after their addition. Herein, an organophosphate flame retardant pentaerythritol bis(phenyl phosphonate) (PBPP) with high thermal stability and phosphorus content was synthesized by the nucleophilic substitution reaction in our laboratory. The introduction of PBPP simultaneously improved the flame retardancy, thermostability and crystallization properties of PLA. Only 3 wt% PBPP endowed PLA composites with UL‐94 V‐0 grade and higher LOI of 28.3% due to its excellent gas phase effect. Moreover, the crystallinity of PLA/PBPP4 was enhanced from 14.2% of PLA to 32.2% with the improvement of 127%. Because of the similar structure and good compatibility between organophosphate flame retardant and PLA matrix, flame retardant PLA/PBPP maintained almost the same strength as neat PLA. This study provided a novel way for the preparation of a high‐performance flame retardant PLA composites with excellent comprehensive properties and it was important to expand the application value of multifunctional PLA materials.
Osteology and reassessment of Dineobellator notohesperus, a southern eudromaeosaur (Theropoda: Dromaeosauridae: Eudromaeosauria) from the latest Cretaceous of New Mexico
Authors: Jasinski Steven E. , Sullivan Robert M. , Carter Aja M. , Johnson Erynn H. , Dalman Sebastian G. , Zariwala Juned , Currie Philip J. 
Published: November 2022

AbstractDromaeosaurids (Theropoda: Dromaeosauridae), a group of dynamic, swift predators, have a sparse fossil record, particularly at the end of the Cretaceous Period. The recently described Dineobellator notohesperus, consisting of a partial skeleton from the Upper Cretaceous (Maastrichtian) of New Mexico, is the only diagnostic dromaeosaurid to be recovered from the latest Cretaceous of the southwestern United States. Reinterpreted and newly described material include several caudal vertebrae, portions of the right radius and pubis, and an additional ungual, tentatively inferred to be from manual digit III. Unique features, particularly those of the humerus, unguals, and caudal vertebrae, distinguish D. notohesperus from other known dromaeosaurids. This material indicates different physical attributes among dromaeosaurids, such as use of the forearms, strength in the hands and feet, and mobility of the tail. Several bones in the holotype exhibit abnormal growth and are inferred to be pathologic features resulting from an injury or disease. Similar lengths of the humerus imply Dineobellator and Deinonychus were of similar size, at least regarding length and/or height, although the more gracile nature of the humerus implies Dineobellator was a more lightly built predator. A new phylogenetic analysis recovers D. notohesperus as a dromaeosaurid outside other previously known and named clades. Theropod composition of the Naashoibito Member theropod fauna is like those found in the more northern Late Cretaceous North American ecosystems. Differences in tooth morphologies among recovered theropod teeth from the Naashoibito Member also implies D. notohesperus was not the only dromaeosaurid present in its environment.
Morphological and functional brain changes in chronic cancer‐related pain: A systematic review
Authors: Vande Vyvere Thijs , De Groote Amber , De Groef An , Haenen Vincent , Tjalma Wiebren , Van Dyck Pieter , Meeus Mira 
Published: November 2022

AbstractThe purpose of this study was to perform a systematic review of the available literature on morphological and functional brain changes measured by modern neuroimaging techniques in patients suffering from chronic cancer‐related pain. A systematic search was conducted in PubMed, Embase, and Web of Science using different keyword combinations. In addition, a hand search was performed on the reference lists and several databases to retrieve supplementary primary studies. Eligible articles were assessed for methodological quality and risk of bias and reviewed by two independent researchers. The search yielded only four studies, three of which used MRI and one PET‐CT. None of the studies measured longitudinal morphological (i.e., gray or white matter) changes. All studies investigated functional brain changes and found differences in specific brain regions and networks between patients with chronic cancer‐related pain and pain‐free cancer patients or healthy volunteers. Some of these alterations were found in brain networks that also show changes in non‐cancer populations with chronic pain (e.g., the default mode network and salience network). However, specific findings were inconsistent, and there was substantial variation in imaging methodology, analysis, sample size, and study quality. There is a striking lack of research on morphological brain changes in patients with chronic cancer‐related pain. Moreover, only a few studies investigated functional brain changes. In the retrieved studies, there is some evidence that alterations occur in brain networks also involved in other chronic non‐cancer pain syndromes. However, the low sample sizes of the studies, finding inconsistencies, and methodological heterogeneity do not allow for robust conclusions.
Endocranial anatomy of the Guercy 1 early Neanderthal from Baume Moula‐Guercy (Soyons, Ardèche, France)
Authors: Richards Gary D. , Jabbour Rebecca S. , Guipert Gaspard , Defleur Alban 
Published: November 2022

AbstractWe provide the first comparative description of the endocranium of the Guercy 1 Early Neanderthal and examine its affinities to Preneanderthals, Neanderthals, and Homo sapiens. The Guercy 1 cranium derives from deposits chronostratigraphically and biostratigraphically dated to the Eemian Interglacial (MIS 5e). For comparative purposes, we compiled a sample of European and Southwest Asian subadult and adult Middle‐to‐Late Pleistocene hominins (≈MIS 12–MIS 1; N = 65). We sampled both a Preneanderthal–Neanderthal group and a Homo sapiens group. The Preneanderthal–Neanderthal group was further divided into three time‐successive subgroups defined by associated MIS stages. Metric and morphological observations were made on original fossils and physical and virtual endocranial reconstructions. Guercy 1 and other Early Neanderthals, differ from Preneanderthals by increased development of the prefrontal cortex, precentral and postcentral gyri, inferior parietal lobule, and frontoparietal operculum. Early Neanderthal differ, in general, from Late Neanderthals by exhibiting less development in most of the latter brain structures. The late group additionally differentiates itself from the early group by a greater development of the rostral superior parietal lobule, angular gyrus, superior and middle temporal gyri, and caudal branches of the superior temporal gyrus. Endocranial morphology assessed along the Preneanderthal–Neanderthal sequence show that brain structures prominent in Preneanderthals are accentuated in Early‐to‐Late Neanderthals. However, both the Early and Late groups differentiate themselves by also showing regionally specific changes in brain development. This pattern of morphological change is consistent with a mosaic pattern of neural evolution in these Middle‐to‐Late Pleistocene hominins.
Understanding the influence of alkali cations and halogen anions on the cooperativity of cyclic hydrogen‐bonded rosettes in supramolecular stacks
Authors: Petelski Andre Nicolai , Fonseca Guerra Célia 
Published: November 2022

AbstractHydrogen‐bonded supramolecular systems are known to obtain extra stabilization from the complexation with ions, like guanine quadruplex (GQ). They experience strong hydrogen bonds due to cooperative effects. To gain deeper understanding of the interplay between ions and hydrogen‐bonding cooperativity, relativistic dispersion‐corrected density functional theory (DFT‐D) computations were performed on triple‐layer hydrogen‐bonded rosettes of ammeline interacting with alkali metal cations and halides. Our results show that when ions are placed between the stacks, the hydrogen bonds are weakened but, at the same time, the cooperativity is strengthened. This phenomenon can be traced back to the shrinkage of the cavity as the ions pull the monomers closer together and therefore the distance between the monomers becomes smaller. On one hand this results in a larger steric repulsion, but on the other hand, the donor‐acceptor interactions are enhanced due to the larger overlap between the donating and accepting orbitals leading to more charge donation and therefore an enhanced electrostatic attraction.
H∞ containment of networked MASs with disturbances, position, and velocity constraints
Authors: Chen Jie , Wang Yalin , Luo Danni , Hou Hailiang , Gui Weihua 
Published: November 2022

AbstractThe objective is to achieve the constrained containment of discrete‐time multiagent systems with external disturbances in directed networks. In contrast to the existing constrained containment results that ignore disturbances, this work incorporates the disturbances, the position, and velocity constraints of followers simultaneously. A projection‐based control protocol is developed to pull all followers into a target area formed by some leaders, and meanwhile, a certain level of disturbance attenuation performance is satisfied. By utilizing the multiple model transformations, convexity analysis, and the Lyapunov approach, a sufficient condition is derived to realize the constrained containment with
performance. Some simulation results are provided to demonstrate the disturbance‐rejection performance of the proposed control method.
Metal–organic frameworks for NH3 adsorption by different NH3 operating pressures
Authors: Bae Cheongwon , Gu Mingyu , Jeon Yuri , Kim Duckjong , Kim Juyeong 
Published: November 2022

AbstractNH3 has been used in wide applications, such as fertilizers, hydrogen sources, and working fluids, where proper NH3 adsorbents are required to minimize human health risks in daily NH3 exposure as well as to achieve energy efficiency in energy conversion systems. As NH3 operating pressure differs from each usage, the structure and properties of the NH3 adsorbent need to be optimized in each NH3 operating pressure. Metal–organic frameworks (MOFs) have emerged as promising NH3 adsorbents, which would be customizable for different NH3 pressures due to great structural tunability. We introduce up‐to‐date reports with MOFs as NH3 adsorbents and classify them by the NH3 pressure, from high in adsorption heat pumps to extremely low in daily life sensing. MOFs with high NH3 adsorption capacity and durability are suggested in different NH3 pressure ranges, and their structural factors are discussed to help design high‐performance MOFs for NH3 adsorption in different NH3 pressures.
Urine metabolomic characteristics of female patients with occupational chronic cadmium poisoning after 15 years of treatment
Authors: Chen Xingyu , Li Guoliang , Zhang Weipeng , Ou Jiayi , Li Hecheng , Huang Yiqi , He Shuirong , Zhou Jiazhen , Zhao Zhiqiang , Chen Jiabin , Meng Xiaojing , Liu Lili 
Published: November 2022

AbstractOccupational chronic cadmium poisoning (OCCP) can cause irreversible organ damage. Currently, no effective treatment is available for OCCP, and effective and sensitive biomarkers for treatment evaluation are still lacking. In this study, metabolomics techniques were used to analyze changes in endogenous metabolites in the urine of patients with OCCP after 15 years of treatment. Thirty urine samples from female patients with OCCP and healthy female controls (n = 15 per group) were assessed using gas chromatography–time‐of‐flight mass spectrometry and ultra‐high‐performance liquid chromatography–Q‐Exactive mass spectrometry. The OCCP group had higher concentrations of blood urea nitrogen and urinary cadmium but near‐normal urinary concentrations of β2‐microglobulin and retinol‐binding protein. Compared with the control group, the OCCP group had 66 significantly different metabolites with a variable importance in projection score >1 and p < 0.05. These differential metabolites were involved in various metabolic pathways, such as creatine metabolism, nicotinate and nicotinamide metabolism, the pentose phosphate pathway, d‐glutamine and d‐glutamate metabolism, and amino acid metabolism. Compared with the control group, the OCCP group had significantly higher urinary concentrations of creatine, glutamic acid, quinolinic acid and nicotinic acid. In a receiver operator characteristic analysis, the area under the curve of creatine was higher than those for glutamic acid, quinolinic acid and nicotinic acid, indicating that urinary concentrations of creatine could be used as a sensitive biomarker for the diagnosis and prognosis of OCCP and for monitoring its treatment.
Fast determination of free metronidazole in rat plasma and peritoneal fluid using HPLC‐UV method
Authors: dos Anjos Michele Vaz , Bergoza Larissa , Fonseca Gisele , Possa Eduarda , dos Santos Paulo , Moura e Silva Sidnei , Tasso Leandro 
Published: November 2022

AbstractPeritonitis refers to the inflammatory reaction of the peritoneum to aggression. In addition, it contributes significantly to sepsis. The presence of free concentrations of antimicrobials above the minimum inhibitory concentration at the site of infection is critical to therapeutic response. Metronidazole (MTZ) is an antimicrobial used to treat peritonitis because of its effectiveness against anaerobic microorganisms. This study investigates free MTZ concentrations in peritoneal microdialysate in Wistar rats. A C18 column (150 × 4.0 mm, 5 μm) was used for the analysis conducted at 40°C under isocratic conditions. The mobile phase consisted of acetonitrile and an aqueous solution of 50‐mM monobasic phosphate buffer and 0.1% triethylamine, with pH 3.0 (10:90, v/v). MTZ calibration was linear in the range of 0.5–30.0 μg/ml. The intra‐ and inter‐day precision was satisfactory with relative standard deviation ≤5.67%. The accuracy ranged from 90.64 to 103.77%, and the lower limit of quantification was 0.5 μg/ml. The developed method was successfully applied in a pilot pharmacokinetic study after MTZ administration (30 mg/kg, intravenously) in rats. The main advantage of the employed method is that it does not require sample processing and protein removal steps. This is the first study to be conducted using MTZ in rats.
Development, validation and application of a gas chromatography method for the determination of dillapiole from Piper aduncum essential oil in skin permeation samples
Authors: Braga Carneiro Simone , Kreutz Tainá , Limberger Renata Pereira , da Veiga Júnior Valdir Florêncio , Koester Letícia Scherer 
Published: November 2022

AbstractThe essential oil extracted from the leaves of Piper aduncum has antifungal, insecticidal and antibacterial activity. Studies with its main compound, dillapiole (DIL) revealed antibacterial and anti‐inflammatory potential. Despite all this bioactivity, there is no updated report on the development and validation of analytical and bioanalytical methodology to quantify DIL in skin samples. A selective, precise, accurate and adequate method for the determination of DIL in solutions, porcine ear skin samples and receptor fluid was developed and validated by headspace extraction–gas chromatography with flame ionization detection (HS–GC–FID). HS–GC–FID was applied to determine DIL in Franz cell permeation and retention studies using porcine ear skin samples. In the HS–GC–FID method, matrix‐related interferences were not observed at the peak of the DIL retention time. The results showed a high recovery (>97%) after the extraction procedure, allowing the quantification of DIL in complex matrices. In vitro permeation/retention for DIL showed cumulative amounts permeated in the order: receptor fluid (21.98 ± 1.19 μg/cm2) > epidermis (15.40 ± 1.20 μg/cm2) > dermis (9.52 ± 1.13 μg/cm2). HS–GC–FID was successfully validated and the results point to DIL transdermal permeation and to the potential to develop pharmaceutical formulations for skin delivery to treat inflammation or infections.
Abnormal downregulation of 10‐formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway
Authors: Qu Yi , He Ying , Ruan Hanjin , Qin Lizheng , Han Zhengxue 
Published: November 2022

AbstractBackground10‐formyltetrahydrofolate dehydrogenase (ALDH1L1) is a major folate enzyme, which is usually underexpressed in malignant tumors and competes with tumors for the same folate substrate. However, the specific role and mechanisms of ALDH1L1 in oral squamous cell carcinoma (OSCC) remainsobscure.MethodsThe expression level of ALDH1L1 in paired OSCC tissues and adjacent noncancerous tissues were detected by quantitative realtime PCR, Western blot and immunohistochemistry. The relationship between ALDH1L1 expression and clinical characteristics was analyzed. Besides, CCK8, EdU staining, colony formation, wound healing, transwell invasion, apoptosis, cell cycle assays and nude mice tumor bearing experiments were employed to assess the role of ALDH1L1 in OSCC. To explore the underlying mechanisms of these effects, cell cycle‐related markers were examined.ResultsIn this study, we revealed that ALDH1L1 expression was significantly reduced in OSCC, and its downregulation was associated with the malignancy of the tumor and poor prognosis of patients. In vivo and in vitro experiments, downregulation of ALDH1L1 in OSCC significantly inhibited the occurrence of NADP+‐dependent catalytic reactions and facilitated tumor cell growth, migration, invasion, survival, cell cycle progression, and xenograft tumor growth. On the contrary, re‐expression of ALDH1L1 plays a similar role to anti‐folate therapy, promoting NADPH production and suppressing the progression of OSCC. Furthermore, ALDH1L1 overexpressing obviously inhibited the expression of PI3K, p‐Akt, CDK2, CDK6, Cyclin D1, Cyclin D3, and Rb in OSCC cells, and promoted the expression of p27. LY294002 and 740 Y‐P were used to confirm the inhibitory effects of ALDH1L1 on OSCC progression through PI3K/Akt/Rb pathway.ConclusionOur findings highlight the clinical value of ALDH1L1 as a prognostic marker and the potential of a new target for anti‐folate therapy.
Comparison of different methods of obturator nerve block in transurethral resection of bladder tumors: A systematic review and network meta‐analysis
Authors: Wu Jinhao , Gao Yafen , Xiong Zhiyong , Xiao Xiong , Yang Jun , Yang Xiong , Huang Yu 
Published: November 2022

AbstractBackgroundBladder cancer is the most common malignancy of the urinary system, and accounts for 3% of newly diagnosed tumors. Transurethral resection of bladder tumor plays a key role in treating bladder cancer, among which one of the most serious complications is bladder perforation caused by obturator nerve reflex. Obturator nerve reflex can be prevented by inducing obturator nerve block after lumbar anesthesia. However, No study so far has compared the inhibitory effect of different obturator nerve block approaches on intraoperative obturator nerve reflex and bladder perforation.MethodIn this study, we conducted a network meta‐analysis (NMA) of studies comparing the efficacy of different obturator nerve block approaches performed after lumbar anesthesia in operation.ResultThe distal obturator nerve block guided by peripheral nerve stimulator is the best approach for preventing obturator reflex. The proximal obturator nerve block guided by ultrasound is the best approach for preventing bladder perforation.ConclusionSpinal anesthesia combined with the distal obturator nerve block guided by peripheral nerve stimulator is the most optimal approach to prevent the obturator nerve reflex. But the doctor should choose the appropriate anesthesia method according to the patient's general condition, tumor location, and doctor's proficiency in puncture techniques.