bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paradoxical increase in global longitudinal strain by handgrip exercise despite left ventricular diastolic dysfunction
Authors: Motoi Ko , Iwano Hiroyuki , Ishizaka Suguru , Nakamura Kouske , Tamaki Yoji , Aoyagi Hiroyuki , Nakabachi Masahiro , Yokoyama Shinobu , Nishino Hisao , Murayama Michito , Kaga Sanae , Anzai Toshihisa 
Published: December 2022

Abstract
Background
Although global longitudinal strain (GLS) is recognized as a sensitive marker of intrinsic left ventricular (LV) dysfunction, its afterload dependency has also been pointed. We hypothesized that GLS during handgrip exercise could be more sensitive marker of intrinsic myocardial dysfunction.
Methods
Handgrip exercise-stress echocardiography was performed in 90 cardiovascular disease patients with preserved LV ejection fraction. LV diastolic function was graded according to the guidelines. Diastolic wall stress (DWS) and ratio of left atrial (LA) volume index to late-diastolic mitral annular velocity (LAVI/a¢) were measured at rest as LV stiffness. As well, LA strains were measured to assess LA function. GLS was expressed as absolute value and significant changes in GLS by handgrip exercise was defined as changes over prespecified mean absolute test-retest variability (2.65%).
Results
While mean value of GLS did not change by the exercise, substantial patients showed significant changes in GLS: decreased (group I, n=28), unchanged (group II, n=34), and increased (group III, n=28). Unexpectedly, patients in group I did not show any clinical and echocardiographic characteristics, while those in group III were characterized by elevated natriuretic peptide levels, blunted heart rate response to handgrip exercise, and advanced LV diastolic dysfunction. Multivariable analyses revealed that DWS, left atrial booster strain, and grade II or more diastolic dysfunction determined the increase in GLS even after adjustment for elevated natriuretic peptides and the changes in heart rate by the exercise.
Conclusion
Paradoxical increase in GLS by handgrip exercise could be associated with advanced LV diastolic dysfunction in cardiovascular patients with preserved LV ejection fraction.
An analysis of the hot forming characteristics of diffusion bonded TC4 alloy using processing maps
Authors: Muhammad Imran Sardar , LI Can , LANG Lihui , LI Yong , ZANG Bo , ULLAH Sattar , LI Xiaoxing 
Published: December 2022

Abstract

Since the hot forming of TC4 alloy after diffusion bonding has extensive applications in aerospace and medical industries, it is practically significant to explore the influence of diffusion bonding on the alloy's hot formability and identify the optimal forming parameters. Therefore, dual-stage diffusion bonding of aviation grade TC4 is carried out firstly at 900 °C for 1 hr and then at 930 °C for 2 hr under 2 MPa normal pressure in 5.0 x 10-3 Pa vacuum atmosphere. Another block of the as-received alloy is subjected to the same thermal loading as the diffusion bonding process. The diffusion-bonded and heat-treated alloys are then subjected to uniaxial tensile tests at 750 – 900 °C and 0.0001 – 0.1 s-1. Based on the tensile test data, the constitutive and dynamic material models are developed to investigate diffusion bonding effects on the alloy's hot forming behavior and identify optimal forming conditions. The developed constitutive model showed good predictability. The apparent activation energy of diffusion bonded (440 – 510 kJ • mole-1) and heat-treated (400 kJ • mole-1) alloys indicated that dynamic recrystallization and recovery are the primary deformation mechanisms. The processing maps revealed that diffusion bonding expanded the instability domain and lowered the dissipation efficiency, limiting the safe working conditions of the alloy. The analysis of deformed microstructure validated the findings of processing maps. The optimal processing conditions of 800 °C/ 0.0001 s-1 and 850 °C/ 0.0001 s-1 are discovered for diffusion-bonded and heat-treated alloys, respectively.
Experimental Study of the Long-term Performance of BFRP Composite Laminates under Flexural Fatigue Test
Authors: Chhorn Buntheng , Lee SangMoon , Jung WooYoung 
Published: December 2022

Abstract
The main objective of the present study is to investigate the flexural fatigue performance of unidirectional basalt fiber/epoxy (BFRP). Three types of composite laminate, i.e., configuration 1 with 0° and 90° directional denoted by [C1/0], [C1/90], respectively, and configuration 2 with 0° directional denoted by [C2/0] were considered. The composite laminates were manufactured using vacuum infusion technique with average thickness (3.2 ± 0.1) mm. Displacement-controlled flexural fatigue test was conducted with a frequency of 10 Hz at a stress ratio of 1. The failure criterion was taken to be a 2 % reduction of the initial flexural stiffness. The failure modes of flexural fatigue test specimens were investigated. The S − N curves of different types of composite laminates were constructed using five specimens for each one as the design curve. Two-parameter Weibull distribution function was used to statistically analyze the long-term fatigue performance of BFRP. Also, the function was implemented to incorporate failure probability into the S − N relationships. Finally, it is observed that both the plies stacking sequence, and the specimen configurations, have significant effects on the S − N relationship.
Stability of Lyophilised Platelet Lysate From Leukocyte-poor Platelet Concentrate as Growth Medium Supplement for Bone Marrow-derived Mesenchymal Stem Cells Culture
Authors: Chitchongyingcharoen Narong , Hassan Shirmeela , Tawonsawatruk Tulyapruek , Tragoonlugkana Patcharapa , Toso Montree , Cotivongsa Pongsaporn , Supokawej Aungkura 
Published: December 2022

Abstract
Mesenchymal stem cells (MSCs) have been extensively studied for clinical purposes due to their positive therapeutic properties. MSCs showed potential roles in immunomodulation and paracrine effects for tissue regeneration. The preparation of MSCs for human use must be conducted under a good manufacturing process (GMP). Human platelet lysate (HPL) is currently recommended for MSC expansion by minimizing content variability and safety concerns from xeno-contamination. However, prolonged storage and temperature volatility may destabilize HPL shelf life. In this study, freeze-drying (lyophilization) was applied to evaluate the quality of lyophilized platelet lysate (LPL) after two years of storage. Media containing FBS, fresh human platelet lysate (fHPL), fresh lyophilized platelet lysate (fLPL), stored human platelet lysate (sHPL), and stored lyophilized platelet lysate (sLPL) were applied in human bone marrow mesenchymal stem cells (BMSCs) expansion. Total cell number, BMSC surface markers, and tri-lineage differentiation were studied. Population doubling time (PDT) of BMSCs cultured in fHPL, fLPL, sHPL and sLPL had rapid growth in comparison with FBS at 32.91 (± 1.34), 34.50 (± 1.25), and 52.04 (± 1.99) hours, respectively. BMSC characteristics, such as cell surface markers and mesodermal differentiation potential, were studied. Adipogenic and chondrogenic differentiation potentials were similar in all culture conditions. Meanwhile, osteogenic differentiation of BMSCs in sHPL and sLPL was enhanced and demonstrated a strong positive stain to Alizarin Red S. BMP-2 and PDGF-BB levels were quantitatively determined in HPL and LPL samples. This study revealed that lyophilization process can preserve the properties of HPL over 2 years storage while also support BMSCs expansion.
Construction of a peptidase gene-based prognostic prediction model for esophageal carcinoma and identification of IMMP1L as a potential tumor biomarker
Authors: jiang jie , Yang Xue-Lian , Wang Zhen , Zhang Dong-Ni , Xie Shi-Yun , Fu Qiu-Xia 
Published: December 2022

Abstract
Background
Esophageal carcinoma (ESCA) is among the most prevalent malignant tumors worldwide, with a high incidence and fatality rate. However, there are presently few biomarkers connected to early diagnosis and treatment. It is essential to find the ideal biomarkers and construct reliable prognostic models.
Methods and Results
We identified 60 peptidase genes with differential expression in the ESCA using expression profiling data in The Cancer Genome Atlas (TCGA). Based on these genes, a prognostic risk model for ESCA was constructed by completing lasso regression analysis, ten-fold cross-validation, univariate Cox proportional hazard regression analysis, and multivariate Cox proportional hazard regression analysis. According to Kaplan-Meier survival analyses, the model demonstrated excellent performance on both the TCGA and the GEO datasets. The nomogram established by the peptidase gene and clinical variables also matched the projected and actual patient survival rates. According to the results of multivariate regression analysis, Inner Mitochondrial Membrane Peptidase Subunit 1 (IMMP1L) can be used as an independent prognostic factor for ESCA. We verified the mRNA expression level of IMMP1L in 15 esophageal cancer tissues, 12 of which were significantly increased. And we have identified the hub genes potentially targeted by IMMP1L.
Conclusions
we constructed and validated a prognostic risk prediction model for ESCA. And it can accurately predict survival in patients by integrating genes and tumor stage. Our results also show that IMMP1L could be used as a prospective biomarker for ESCA. These could help in the early detection and treatment of ESCA, increasing patient survival rates.
Ecological Mortar from Recycled Composite Powder with Waste Clay Brick and Coal Gangue
Authors: Wang Binglei , Li Jun , Lyu Boning , Ma Jianhua 
Published: December 2022

Abstract
The clay brick and powder recycled from construction and industrial waste may be utilized as recycled construction materials. To alleviate the negative environmental impact of the cement industry’s CO2 emission, waste clay brick was used as fine aggregate, clay brick powder (CBP), and coal gangue powder (CGP) were utilized as supplementary materials to partly substitute the cement. The physical properties, mechanical properties, and durability of ecological mortar were investigated with microstructure analysis and revealed that the replacement of cement with recycled composite powder generally harms the performance of ecological mortar, and this impact is found to be less significant in proper mix proportions (5:5). Furthermore, a limited clay brick fine aggregate (CBFA) replacement rate under 20% exhibited higher mechanical properties. The hydration products of pozzolanic activity resulted in densification and enhanced the microstructure of the mortar framework. The result obtained by the investigation help promote the development of the synergetic application of waste clay brick and coal gangue as supplementary cementitious materials in the full component ecological mortar and green construction materials.
Genetic profile of gamma irradiated Locusta migratoria migratorioides: A futuristic eco-friendly control approach
Authors: Ali Hanaa , Fathy Zeinab , Ibrahim Samah , Sayed Rehab 
Published: December 2022

AbstractThe most common species of grasshopper in Africa is calledLocusta migratoria migrotaria (L.), and it is thought to pose a severe danger to agriculture worldwide. TheLocusta migratoriaspecies developed resistance to insecticides because of overuse, which also polluted the environment. As a result, opportunities to investigate new control strategies appeared. The purpose of the current study is to assess the effectiveness of gamma radiation in eradicating Locusta species and to look into the DNA alterations caused by radiation exposure in both male and female insects. Males and female adults (around one-month-old) received radiation treatments of 10, 20, 30, and 40 Gy. DNA isolation and Start codon targeted polymorphism (SCoT-PCR) analysis were done, along with mortality percentage calculations. The death rate increased significantly over time as a result of gamma irradiations resulting in an estimated LD50value for males and females of 33.94 and 51.55Gy, respectively. According to the SCoT research, the adults' radiation exposure resulted in the disappearance of some bands and the appearance of new additional bands. The similarity index was used to create a dendrogram. It was determined that irradiating the pest may be used as a technique to kill the insect and stop its spread. In addition, it resulted in certain genetic alterations within this species. Conclusions: The control ofL.may be suggested by utilizing radiation technology, after further field studies.
Evaluation of active labor market policy reform: Employment outcomes of employment rehabilitation services
Authors: Pesor Renee , Põder Kaire 
Published: December 2022

Abstract

Purpose
The purpose of this study is to examine the effect of the Estonian active labor market reform in 2016, which introduced a new policy concerning employment rehabilitation services. As a research question, we investigate how such services may have affected the employment outcomes of people with mental and/or physical impairments.
Methods
Our sample includes 9,244 people from 2016 to 2020, with a mean age of 46 years. Due to multiple entries to the services, we have more than 11,000 episodes, and monthly panel property increases the number of observations by over 100,000. We use propensity score matching in combination with fixed effects panel regressions to analyze how the completion of the scheduled rehabilitation plan affected monthly employment duration.
Results
Our results indicate that completing the rehabilitation service yields on average 2.6 months longer post-rehabilitation employment, compared to matched individuals who discontinued the service. This effect was larger when already employed and male participants entered the service, while weaker effects were observed in the case of individuals with only mental disabilities.
Conclusions
Overall, we conclude that while completing the scheduled rehabilitation plan has a positive effect on employment outcomes, still maintaining employment status seems to remain a challenge, based on the relatively modest effect sizes. Thus, we question the economic arguments behind the reform.
Development and validation of Adaptability to Return-to-Work Scale (ARTWS) for cancer patients
Authors: Li Jia-mei , Gu Li-pei , Xu Jia-shuo , Su Xiao-qin , Guo Yu-jie 
Published: December 2022

Abstract
Objective: To develop the Adaptability to Return-to-Work Scale (ARTWS) for cancer patients and evaluate its psychometric properties.
Methods: In stage 1, the items of the initial scale were compiled based on the theoretical model, interview coding topics, and literature review results. Afterward, through two rounds of Delphi expert consultation and a pilot survey, the initial scale was further checked and revised. In stage 2, the psychometric properties of the ARTWS were assessed. Reliability was assessed by internal consistency and test-retest reliability evaluation. Exploratory Factor Analyses (EFA) and Confirmatory factor analysis (CFA) were performed to examine the construct validity. Moreover, the content validity was evaluated by the scale level content validity index (S-CVI).
Results: The final ARTWS for cancer Patients consisted of 24 items. EFA extracted "Focusing on rehabilitation", "Rebuilding Self- efficiency", and "Adjusting plans" as common factors in determing adaptability of cancer patients to return-to-work, and the cumulative variance contribution rate for these three factors was 66.6%. The S-CVI of the total scale was 0.979. The Cronbach's α coefficient was 0.937. The 2-week test-retest reliability was 0.814. CFA showed that after model modification, the fitting of the model was within the acceptable range.
Conclusion: The developed ARTWS for adult cancer patients has good reliability and validity, which can be used as a tool to measure the adaptability of cancer patients' return-to-work.
Ultrasonic-Assisted Dyeing of Nylon 6 Electrospun Nanofibers
Authors: Khatri Awais , Ali Shamshad , Javeed Alishba 
Published: December 2022

Abstract
This study was carried out to address sustainability aspect of ultrasonic-assisted dyeing of nylon 6 electrospun polymeric nanofibers with reactive dyes using batchwise dyeing process specially in terms of reducing the wastewater pollution and energy. For this, nylon 6 nanofibers were prepared on an electrospinning technique and then dyed with reactive dyes by both conventional (CN) and ultrasonic (US) assisted dyeing methods. The influence of factors that may affect the dyeability of nylon 6 nanofiber with reactive dyes were simultaneously carried out using both CN and US dyeing methods. The spectrophotometric measurement of dyed samples was carried out to determine the color coordinates and color yield values. Colour yield (K/S) value up to 1.72 was achieved using US energy in dyeing nylon 6 nanofibrous mats with reactive dyes. As an additional experiment, the TDS contents of the effluent of US dyeing was reduced to 28% comparing to that of the CN dyeing, demonstrating the ecological merit of the US dyeing process. And, the potential of saving in thermal energy (up to1200 kcal), dyeing time (66.7%) and amount of reactive dye (up to 25%) were realized in US dyeing in comparison to the CN dyeing. Moreover, scanning electron microscopy and ATR-FTIR spectroscopy analysis were also carried out for this study.
Clinical Characteristics and Risk Factors of Acute Lymphoblastic Leukemia Children Complicated with Severe Infection during the Maintenance treatment
Authors: Yin Tiantian , Han Juan , Hao Jinjin , Yu Hui , Qiu Yining , Xu Jiawei , Peng Yun , Wu Xiaoyan , Zhou Fen , Jin Runming 
Published: December 2022

Abstract

Purpose
Infection is the most common adverse event of acute lymphoblastic leukemia (ALL) treatment and also one of the main causes of death. To investigate the clinical characteristics and risk factors of severe infection during the maintenance phase of ALL treatment, we conducted a retrospective study.
Methods
We collected clinical data of ALL children, and analyzed the clinical features and risk factors of severe infection by χ2 test and binary Logistic regression.
Results
A total of 181 children were eligible, and 46 patients (25.4%) suffered from 51 events of severe infection, most of which occurred in the first half year of the maintenance phase (52.9%). The most common infection was pulmonary infection (86.3%) and followed by bloodstream infection (19.6%). The positive rate of pathogen detection was low (17.6%, 44/250), and the most common one was fungal infection. The main symptoms of ALL patients with pulmonary infection were fever, cough and shortness of breath. The main manifestations of CT were ground glass shadow (56.8%), consolidation shadow (27.3%) and streak shadow (25%). Binary logistic regression analysis showed that agranulocytosis, agranulocytosis ≥ 7 days, anemia and low globulin level were independent risk factors for severe infection during the maintenance phase (all P < 0.05).
Conclusion
Blood routine examinations and protein levels should be monitored regularly for ALL patients in the maintenance phase, especially in the first six months. For ALL patients with the risk factors, preventive anti-infective therapy or supportive therapy can be given as appropriate to reduce the occurrence of severe infection.
Powdery mildew-induced changes in phyllosphere microbial community dynamics of cucumber
Authors: yue cong , Du Changxia , Tan Yinqing , Liu Xingchen , Fan Huaifu 
Published: December 2022

Abstract
As an important habitat for microorganisms, the phyllosphere has an important impact on plant health and growth. The changes of the phyllosphere microorganisms are closely related to the occurrence of leaf diseases. However, little is known about how the microbial community changes in the phyllosphere under the infection of pathogen. Here, we analyzed the microbial communities in the phyllosphere at different disease levels (L1 ≤ 10%, 30% ≤ L2 < 50%, and L3 ≥ 50%) to explore the dynamic changes of the phyllosphere microorganisms. The analysis showed that bacterial microbial community diversity increased with disease severity and fungal diversity gradually decreased. There were no significant differences in the community structure and composition of phyllosphere microorganisms at different levels of incidence, the relative abundance of species changed significantly. The relative abundance of rosenbergiella, rickettsia and cladosporium was negatively correlated with the severity of the disease, while bacillus, pantoea, kocuria and podosphaera were positively correlated with the severity of the disease. Co-occurrence network showed that both fungal and bacterial communities L1 have relatively stable and complex ecological networks. The bacterial network tends to be unstable with the increase in disease degree, and the fungal network gradually stabilizes. These studies showed that the severity of the disease will have a certain impact on the phyllosphere microbial community, which provides a new reference for cucumber powdery mildew control from a microbial perspective.
Membranous Septum Length Predicts New Conduction Abnormalities in Surgical Aortic Valve Replacement - A novel predictor for PPMI after SAVR
Authors: Nakashima Makoto , Jilaihawi Hasan , He Yuxin , Williams David , Pushkar Illya , Williams Mathew , Hisamoto Kazuhiro 
Published: December 2022

Abstract
PURPOSE
The membranous septum (MS) length measured by cardiac computed tomography (CT) is useful for the prediction of permanent pacemaker implantation (PPMI) and new left bundle branch block (LBBB) after transcatheter aortic valve replacement. However, its predictive value for patients undergoing surgical aortic valve replacement (SAVR) is unknown.
Methods
A total of 2531 consecutive patients were registered in the institutional Society of Thoracic Surgeons database between July 2017 and June 2020. Excluding non-SAVR procedures, prior pacemaker/implantable cardioverter defibrillator, prior SAVR, no pre-procedural CT assessment and suboptimal CT imaging.
Results
A total of 126 SAVR with pre-procedural CT assessment were analyzed. Bicuspid aortic valve morphology was confirmed on CT in 59.5% of patients. There were three new PPMIs and five new LBBBs observed after SAVR at the time of discharge. In-hospital mortality was 0.8%. Low left ventricular ejection fraction (< 50%), left ventricular (LV) mass index > 120 g/m2, large right coronary artery height and MS length < 1.5 mm predicted new PPMI/LBBB. Multivariate analysis showed LV mass index > 120 g/m2 (odds ratio: 9.165; 95% confidence interval: 1.644-51.080; p = 0.011) and MS length < 1.5 mm (odds ratio: 14.449; 95% confidence interval: 1.632-127.954; p = 0.016) were independent predictors for new PPMI/LBBB.
Conclusion
Short MS length on preoperative cardiac CT is a powerful and novel predictor for the risk of new PPMI/LBBB after SAVR. Special care should be taken in patients with short MS length to avoid suture-mediated trauma.