bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of green innovation on manufacturing small and medium enterprises corporate social responsibility fulfillment: The moderating role of regional environmental regulation
Authors: Yu Feifei , Jiang Dong , Wang Teng 
Published: January 2022

AbstractResearchers have found that small and medium enterprises (SMEs) are also socially responsible, but corporate social responsibility (CSR) literature has been predominantly examined of larger enterprises. Besides, SMEs experience mo re difficulty than larger enterprises in CSR fulfillment. Based on resource‐based theory and green innovation theory, this paper contributes to CSR literature by examining the impact of SMEs’ green innovation on their CSR and the moderating roles of governmental regulations. By analyzing the questionnaire data from 269 manufacturing SMEs, we empirically find that: (1) There is an inverse U‐shaped curve between green innovation and manufacturing SMEs CSR; (2) Command‐and‐control environmental regulations and market‐based environmental regulations both have a moderating effect on the relationship between green innovation and manufacturing SMEs CSR fulfillment. The conclusions can effectively guide the executives of SMEs to fulfill their CSR and guide the formulation of relevant environmental policies for local government.
An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery
Authors: Wang Yang‐Yang , Chang En‐Qiang , Zhu Rui‐Lou , Liu Xiao‐Zhuan , Wang Guang‐Zhi , Li Ning‐Tao , Zhang Wei , Zhou Jun , Wang Xiang‐Dong , Sun Ming‐Yang , Zhang Jia‐Qiang 
Published: January 2022

AbstractBackgroundThe number of patients receiving anaesthesia is increasing, but the impact of general anaesthesia on the patient's immune system remains unclear. The aim of the present study is to investigate dynamics of systemic immune cell responses to anaesthesia during perioperative period at a single‐cell solution.MethodsThe peripheral blood mononuclear cells (PBMCs) and clinical phenomes were harvested and recorded 1 day before anaesthesia and operation, just after anaesthesia (0 h), and 24 and 48 h after anaesthesia. Single‐cell sequencing of PBMCs was performed with 10× genomics. Subsequently, data analysis was performed with R packages: Seurat, clusterProfiler and CellPhoneDB.ResultsWe found that the cluster of CD56+ NK cells changed at 0 h and the cluster of monocytes increased at 24 and 48 h after anaesthesia. The characteristic genes of CD56+ NK cells were mainly enriched in the Jak‐STAT signalling pathway and in cell adhesion molecules (24 h) and carbon metabolism (48 h). The communication between CD14+ monocytes and other cells decreased substantially 0 and 48 h after operation. The number of plasma cells enriched in protein export in men was substantially higher than that in women, although the total number in patients decreased 24 h after operation. CD14+ monocytes dominated that cell‐cell communications appeared in females, while CD8+ NKT cells dominated that cell‐cell communications appeared in male. The number of plasma cells increased substantially in patients with major surgical trauma, with enrichments of pentose phosphate pathway. The communications between plasma cells with other cells varied between surgical severities and anaesthetic forms. The intravenous anaesthesia caused major alterations of cell types, including CD14+ monocytes, plasmas cells and MAIT cells, as compared with inhalation anaesthesia.ConclusionWe initially reported the roles of perioperative anaesthesia/surgery in temporal phenomes of circulating immune cells at a single‐cell solution. Thus, the protection against immune cell changes would benefit the recovery from anaesthesia/surgery.
Automated online dried blood spot sample preparation and detection of anabolic steroid esters for sports drug testing
Authors: Jing Jing , Shan Yuanhong , Liu Zhao , Yan Hui , Xiang Ping , Chen Peijie , Xu Xin 
Published: January 2022

AbstractDried blood spots (DBSs) provide a valuable complementary sample matrix for routine doping analysis, and the full automation of analysis for DBS samples is achievable to avoid extensive and repetitive manual laboratory work. In the current study, a fully automated online DBS preparation and detection method for the screening and quantification analysis of 13 anabolic steroid esters by means of the DBSA‐TLX‐HRMS system was developed and validated, based on the purpose for the determination of the abuse of anabolic steroid esters in athletes. Validation of the method yielded linear (R2 > 0.99), precise, and accurate (RSD% and Re% < 20% at low, medium, and high concentration levels) results. The LOD of testosterone laurate was established at 0.5 ng/ml and at 0.2 ng/ml for other steroid esters. The extraction recovery of the target compounds from DBS ranged from 10.5% to 88.9%, and matrix effects were moderate. Furthermore, the developed and validated method was applied in the analysis of DBS samples collected after the oral administration of a single dose of 80 mg testosterone undecanoate demonstrating its applicability. Evaluation of analyte stability showed that testosterone undecanoate are more stable (8 weeks) in DBS samples of administration study when stored in frozen (−20°C) condition compared with cold storage (4°C). Collectively, these findings demonstrate the applicability of automated DBS analysis in doping control for detection of anabolic steroid esters.
Conformational Analysis and Through‐Chain Charge Propagation in Ferrocenyl‐Conjugated Homopeptides of 2,3‐Diaminopropionic acid (Dap)
Authors: Biondi Barbara , Bisello Annalisa , Cardena Roberta , Schiesari Renato , Facci Martino , Cerveson Laura , Rancan Marzio , Formaggio Fernando , Santi Saverio 
Published: January 2022

AbstractThis work reports a detailed conformational and electrochemical study of two series of ferrocene (Fc)‐peptide conjugates, based on the side‐chain protected, 2,3‐diaminopropionic acid (L−Dap). In one series Fc is linked to the N‐terminus, in the other to the C‐terminus of the Dap homo‐peptides. The conformational analysis carried out in solution (IR absorption and NMR) and in the crystal state (X‐ray diffraction) suggests that these peptides adopt a 310‐helical structure. Cyclic voltammetry showed that the peptide length positively or negatively affects the oxidation potential of Fc. The two opposite trends are correlated to the different orientation of the macrodipole moment of the 310‐helix in the two series with respect to the position of the Fc group in the chain. Finally, the variation of the IR absorptions upon chemical oxidation indicates that our 310‐helical conjugates are very efficient in transferring the positive charge along the peptides through the H‐bond network.
Circular RNA hsa_circ_0000285 regulates the microRNA‐599/G‐protein subunit gamma 12 (miR‐599/GNG12) axis to promote glioma progression
Authors: Liu Fei , Duan Chen , Han Ya 
Published: January 2022

AbstractObjectiveGlioma is the most common, rapidly progressing, lethal brain tumor. However, underlying mechanisms behind its abnormal progression remain largely unknown. This study aimed to investigate mechanism of action and effects of the hsa_circ_0000285 on glioma progression.MethodsRT‐qPCR was utilized to study RNA expression in glioma tissues and cell lines. The effects of hsa_circ_0000285 on glioma progression were studied by measuring cell proliferation and migration, apoptosis, tumor volume and weight in both glioma cells and xenograft glioma mice. The features of hsa_circ_0000285 were identified using chromatin fractionation and RNase digestion. Its mechanism of action was analyzed using bioinformatics, RNA‐binding protein immunoprecipitation, and luciferase reporter assay.ResultsWe found glioma tissues and cell lines were overexpressing hsa_circ_0000285. While hsa_circ_0000285 promoted cell proliferation and migration, it inhibited apoptosis in vitro. It also increased tumor volume and weight in vivo. Using bioinformatic analysis and verification experiments for studying its mechanisms, we confirmed that hsa_circ_0000285 sponged miR‐599, which negatively regulated GNG12 by binding to its mRNA.ConclusionHsa_circ_0000285 is overexpressed in the glioma and promotes its progression by directly regulating the miR‐599/GNG12 axis. This novel mechanism, therefore, shows that the hsa_circ_0000285/miR‐599/GNG12 axis may be a promising therapeutic target for glioma treatment.
A simple and efficient approach for the clickability of super‐bulky aryl azides
Authors: Adinarayana Mannem , Siddhant Kumar , Vaddamanu Moulali , Sathyanarayana Arruri , Rengan Aravind Kumar , Hisano Kyohei , Tsutsumi Osamu , Prabusankar Ganesan 
Published: January 2022

AbstractThe new super bulky 2‐benzhydryl‐4,6‐dimethyl azide (2) was synthesized and used in click reaction for the synthesis of super‐bulky 1‐(2‐benzhydryl‐4,6‐dimethylphenyl)‐4‐phenyl‐1H‐1,2,3‐traizole (3). Further, the 1‐(2‐benzhydral‐4,6‐dimethylphenyl)‐3‐methyl‐4‐phenyl‐1H‐1,2,3‐traizol‐3‐ium iodide (4) was isolated from the reaction between 3 and methyl iodide. These molecules were examined by FT‐IR, TGA, CHN analysis, (1H and 13C) multinuclear NMR, UV–Vis, fluorescence, and SCXRD techniques. Molecules 2 and 3 depict the CH····π intermolecular interactions, while 4 exhibits a rare intermolecular I····HC(sp2) interactions (2.821 Å). The thermal stability of new super bulky triazole (3) and triazolium salt (4) was further exhibited by thermogravimetric analysis. The photophysical properties were investigated.
SARS‐CoV‐2 intralineage variation and temporal patterns of COVID‐19 risk factors in three cities of southeastern Brazil: Age, sex, and race
Authors: Eterovic André , Sperança Márcia Aparecida , de Campos Ivana Barros , Colpas Daniela Rodrigues , Rodart Itatiana Ferreira , Carmo Andréia Moreira dos Santos , de Mattos Elaine Cristina , Daros Vilma dos Santos Menezes Gaiotto , Cergole‐Novella Maria Cecilia 
Published: January 2022

AbstractThe Santo André Regional Center from Adolfo Lutz Institute evaluated 91 537 samples by reverse transcription‐polymerase chain reaction (RT‐PCR) to detect severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) from March 2020 to April 2021. The age, sex, and race of patients from three cities in southeastern Brazil, namely São Bernardo do Campo (SBC), Diadema, and Mauá were assessed in association to the rate of positive results using generalized linear models. Circulating lineages were obtained from GISAID and intralineage genetic variation was investigated employing Lasergene software. A declining number of reported cases around October to November 2020 separate two epidemic waves in the three cities. Mauá differed by the highest positive RT‐PCR scores in January and February. GISAID classification of 38 SARS‐CoV‐2 complete genomic sequences showed the circulation of lineages P.1, B.1.1.28, P.2, B.1.1.332; P.1, P.2, B.1.1.28, B.1.1.33; and P.1, P.2 in SBC, Diadema and Mauá, respectively. Intralineage variation revealed a significant amino‐acid substitution in the ORF3a encoding protein (A33S) present in four out of six (67%) P.1 Mauá isolates. As ORF3a encodes a nonselective Ca2+permeable cation channel, supposed to interfere in airway homeostasis, specific mutations could increase its pathogenic effect resulting in a higher number of symptomatic individuals explaining why the second wave was more intense in Mauá city.
Bio‐engineering of microalgae: Challenges and future prospects toward industrial and environmental applications
Authors: Muthukrishnan Lakshmipathy 
Published: January 2022

AbstractMicroalgae are complex metabolic machineries whose potential has been continuously tapped for wide range of applications. Their suboptimal biomass yield and bioactives production remain the mainstay for their commercialization. To surpass the limitations, genetic engineering and its decisive role in strain improvement have led to the enhancement of quality and yield of products. Meanwhile, the sporadic use of genetic engineering tools specifically toward microalgal strains has limited their applicability. In this context, this article was mainly prepared to highlight the characteristics of microalgae and the introduction of omics approach for the improvement of strain for biorefinery processes. Furthermore, genome editing and gene‐interfering tools to augment algal research using reference strains have been described. The progress made by genetic engineering in editing a gene using CRISPR‐Cas9 and metabolic engineering of microalgae for biofuel production and CO2 sequestration have been critically reviewed. As a futuristic alternative, the transgenic microalgae would compete with the existing resources reducing the dependency on fossil fuel in terms of cost, energy production, and efficacy.
Systematic investigation on anode etching residue widely generated in manufacturing of low‐temperature polycrystalline‐Si active matrix organic light‐emitting diode
Authors: Jin Yu , Ao Wei , Liu Bin , Lu Yunlei , Li Lei , Xi Wangfeng , Jiang Jijun , Ma Mingdong , Hu Fei , Fu Dongzhi , Wang Dongping , Wang Enlai , Jiang Song 
Published: January 2022

AbstractEtching residue is a kind of thorny technological issue in the manufacturing of flat panel. In this work, we report on a systematic investigation on anode etching residue which is widely generated in the manufacturing of low temperature polycrystalline Si‐active matrix organic light emitting diode (LTPS‐AMOLED). Firstly, we proposed three kinds of residue formation mechanisms, including the Bernoulli equation‐based dynamic process, as well as two other situations caused by absence of electrochemical accelerated reaction and organic residue in preprocessing, respectively. Then, residue related failure model of product defects was clarified and considered to give rise to ~3.1% product yield loss owing to the related phenomenon named dark line. Finally, we provided three solutions based on the formation mechanism and failure model, and superior process and design implementation conditions were obtained with detailed experimental verifications, which can be promising methods to solve other related issues in the manufacturing to bring cost down.
Cerium citrate as ecologically friendly corrosion inhibitor for AA7075 alloy
Authors: Marunkić Dunja , Pejić Jovanka , Jegdić Bore , Marinković Aleksandar , Radojković Bojana 
Published: January 2022

AbstractThe corrosion behaviour of high‐strength AA7075 aluminium alloy in NaCl solution, without and in the presence of environmentally friendly corrosion inhibitors (Ce‐chloride and Ce‐citrate) in low concentrations (<0.5 mM), was analysed. The degree of precipitation of the solid solution of AA7075 alloy was determined by measuring the electrical conductivity, while the surface morphology and appearance of intermetallic compounds before and after corrosion testing were analysed by SEM/EDS method. The general corrosion resistance of the tested alloy in NaCl solution and the degree of the inhibitory effect of the corrosion inhibitors were determined on the basis of electrochemical impedance spectroscopy and polarization measurements, while resistance to pit formation on the bases of Epit. AA7075 alloy showed high resistance to general corrosion in the presence of both tested inhibitors, while resistance to pit formation was significantly higher in the presence of Ce‐citrate (concentration 0.5 mM). Also, Ce‐citrate present in NaCl solution at lower concentrations provides satisfactory resistance of AA7075 alloy to general and pitting corrosion. A mechanism of protective action of Ce‐citrate inhibitor has been proposed.
Optimal convergence rates for Galerkin approximation of operator Riccati equations
Authors: Burns John A. , Cheung James 
Published: January 2022

AbstractIn this paper we consider the problem of determining optimal convergence rates of Galerkin approximations to infinite dimensional operator Riccati equations (OREs). Optimal rates are obtained for a class of abstract distributed parameter systems evolving in an infinite dimensional Hilbert space. These general results are then applied to systems modeled by partial differential equations that generate compact and analytic semigroups. The estimates apply to distributed control and observation of classical parabolic equations and to certain vibration problems with sufficiently strong damping. The ORE is formulated as an equivalent operator‐valued Bochner integral equation and the Brezzi–Rappaz–Raviart theorem is used to obtain convergence rates. First we establish smoothing property and bounds for the solutions of the infinite dimensional ORE. Then it is shown that, under sui\ assumptions on the coefficients and domain geometry, the hp‐finite element approximations of the classical solution converges on the order of . Furthermore, these optimal error bounds are shown to hold for the functional gains that define observer and control gain operators. We provide numerical examples that corroborate the theoretical convergence rates.
Fetal echocardiographic markers to differentiate between a right and double aortic arch
Authors: Van Poppel Milou P. M. , Zidere Vita , Simpson John M. , Vigneswaran Trisha V. 
Published: January 2022

AbstractObjectivesTo describe the fetal echocardiographic features of a double aortic arch (DAA) and secondly, to assess the performance of these features to differentiate between a right aortic arch with left duct (RAA‐LD) in a blinded cohort of vascular rings.MethodsReview of records to identify surgically confirmed cases of DAA diagnosed prenatally from 2014 to 2018 (cohort‐A). Prenatal echocardiograms were reviewed and the segments of the aortic arches anterior and posterior to the trachea, aortic isthmuses and the presence/absence of the Z‐sign were described. The utility of these markers were assessed in a separate cohort (B) of fetuses with surgically confirmed cases of DAA or RAA‐LD.ResultsCohort‐A comprised 34 cases with DAA; there was a dominant RAA in 32/34 (94%) and balanced left aortic arch (LAA) and RAA in two cases. The proximal LAA was seen in 29/34 (85%), distal LAA in 15/34 (44%) and the LAA aortic isthmus in 4/34 (12%). The “Z” configuration was present in 29/34 (85%) cases. The most predictive marker for DAA in cohort‐B was the Z‐sign (sensitivity: 100%, specificity: 81%).ConclusionThe “Z” sign is a useful differentiator between RAA‐LD and DAA. The absence of visualization of the left aortic isthmus does not preclude the presence of a DAA.
How does the Untire app alleviate cancer‐related fatigue? A longitudinal mediation analysis
Authors: Spahrkäs Simon S. , Looijmans Anne , Sanderman Robbert , Hagedoorn Mariët 
Published: January 2022

AbstractObjectiveA waiting‐list randomized controlled trial supported the effectiveness of the multimodal Untire app in reducing cancer‐related fatigue (CRF) in cancer patients and survivors. However, little is known about the causal mechanisms of different app components through which the intervention effect was achieved. We aim to examine whether specifically targeted factors (i.e., fatigue catastrophizing, depression, mindfulness, sleep, and physical activity) mediated the intervention effects of the Untire app on fatigue outcomes.MethodsSeven hundred ninety‐nine persons with CRF were randomized (2:1) into intervention (n = 519) and waiting‐list control (n = 280) groups. Self‐report data on the primary outcome fatigue severity and interference and the abovementioned potential mediators were collected at baseline and 12 weeks. Participants who completed the 12‐week assessment were included in the analyses (intervention = 159; control = 176). We performed longitudinal multi‐categorical multiple mediation analysis using PROCESS macro to examine whether the potential mediators explained the overall intervention effects.ResultsImprovements in fatigue catastrophizing (bootstrap 95% CI (−0.110; −0.011)), depression (bootstrap 95% CI (−0.082; −0.004)), and mindfulness (bootstrap 95% CI (−0.082; −0.002)), significantly mediated the intervention effect on fatigue severity, whereas sleep quality (bootstrap 95% CI (−0.081; 0.009)), sleep disturbance (bootstrap 95% CI (−0.038; 0.029)), and physical activity (bootstrap 95% CI (−0.068; 0.000)) did not. Similar associations were found for fatigue interference.ConclusionsUntire app access reduces fatigue severity and interference mainly by decreasing fatigue catastrophizing, depression, and by increasing mindfulness. Supporting these psychological mechanisms is crucial for reducing fatigue among cancer patients and survivors.
Disparities in tracheostomies and gastrostomy tubes in infants at the edge of viability
Authors: Elgendy Marwa M. , Aly Hany , Adisa Afeez , Mohamed Mohamed A. 
Published: January 2022

AbstractObjectivesTo assess trends of clinical practice of tracheostomy and gastrostomy tube (G‐tube) placement over a 25‐year period and to assess the association of both procedures with outcomes in extremely low birth weight (ELBW) infants (<1000 g).MethodsWe reviewed and analyzed data obtained from the National Inpatient Sample dataset from 1993 to 2018. ELBW infants who received a tracheostomy and or G‐tube were included. Regression analysis was performed to assess the association of tracheostomy and/or G‐tube placement with mortality after controlling for confounding variables.ResultsA total of 620,061 ELBW infants were identified in the weighted sample. Of them, 221,339 were included. G‐tube was placed on 4867 (2.2%) infants, tracheostomy was placed on 1788 (0.8%) infants, and both procedures were placed on 1026 (0.46%). Mortality was highest (26.9%) in infants who received tracheostomy only and lowest (5.5%) in those who had G‐tube only and (17.8%) in those who had both procedures with adjusted odds ratios of 7.1 (6.3–7.9), 0.7 (0.6–0.8), and 3.7 (3.1–4.4), respectively. The length of stay (LOS) was highest with the combined procedure (219 ± 171), and lowest in the nonintervention group (88 ± 57). The trend of G‐tube placement has increased over the years (p < 0.01) but tracheostomy placement has decreased over time.ConclusionTracheostomy is associated with increased mortality in ELBW infants and increased LOS in survivors whereas the placement of both tracheostomy and G‐tube is independently associated with decreased mortality. Prospective studies are needed to assess the relationship between clinical presentation, the timing of the procedure, and outcomes.