bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finally, some “me time”: A new theoretical perspective on the benefits of commuting
Authors: Pindek Shani , Shen Winny , Andel Stephanie 
Published: October 2022

Most research on commuting has focused on its negative aspects and consequences (i.e., stress). However, some work has also begun to recognize that there may be positive aspects to commuting. In this paper, we develop a perspective that has so far received limited attention, highlighting how the commute can be experienced as desired and beneficial “me time”, due to the fact that it inhabits a “third space” that is less associated with work or home role requirements. Drawing upon and integrating theories and research on commuting, leisure, recovery, and identity, we first define this construct and then develop a theoretical model that aims to address key questions regarding predicting motivation to engage in “me time”, beneficial outcomes of “me time”, and potential moderators of these effects. Consequently, our proposed model offers both research and practical implications for commuting employees as well as their employers, families, and society. Plain Language Summary The majority of research on commuting has focused on its negative aspects and consequences (i.e., stress). However, increasingly, some work has also begun to recognize that there may be some positive aspects of commuting. Despite some scholars acknowledging the potential benefits of commuting, most still conceptualize the commute as simply a necessary transition between domains (i.e., work and home). In this paper, we seek to bring a new perspective to the literature, highlighting how the commute can be experienced as desired “time to myself”. We therefore develop a theoretical model that aims to address key questions surrounding this phenomenon, including what is “me time” during the commute, who is more likely to uses the commute for “me time”, what are the situational factors that facilitate or inhibit choosing “me time”, what positive outcomes can be expected when engaging in “me time”, and what conditions are likely to affect this process. We also discuss the underlying mechanisms for this process. As a result, our proposed model presents both research and practical implications for commuting employees as well as their employers, families, and society.
Study on dynamic response and safety control of reinforced concrete rigid frame structure under foundation pit blasting
Authors: Zhang Shuoyan , Zhou Chuanbo 
Published: October 2022

Subway station is usually located in the dense area of urban buildings (structures). The blasting construction of subway station foundation pit is bound to have adverse effects on adjacent buildings (structures). Therefore, it is necessary to study the dynamic response of the building (structure) and propose the safety threshold of vibration velocity. Based on the foundation pit blasting project of Hejialong Station of Wuhan Rail Transit Line 12, the vibration monitoring of the field blasting test is carried out. Combined with LS-DYNA numerical simulation software, the dynamic response characteristics of a reinforced concrete rigid frame natatorium near the foundation pit are studied, and safety thresholds for structural vibration velocities are derived. It is worth noting that the structure is a large span reinforced concrete rigid frame structure, which is different from the general reinforced concrete frame structure. The safe allowable vibration velocity in the specification is not fully applicable to the structure. Therefore, it is necessary to focus on the dynamic response of the structure under the blasting effect and propose the safety threshold of structural vibration velocity, which can provide reference for the subsequent foundation blasting. The results are as follows: Blasting seismic waves in different propagation media, their energy attenuation is different. By analyzing the vibration velocity of reinforced concrete rigid frame structures, it is found that the high-level amplification effect occurred at specific height range. In addition, the vibration velocity changes abruptly at the parts where the shape and dimensions of the rigid frame cross-section change. The peak vibration velocity and the maximum principal stress of the concrete elements were statistically analyzed to obtain the linear relationship equation, and the vibration velocity safety control threshold of the structure was predicted to be V = 5.089 cm/s.
Exploring low-income migrant workers’ health information-seeking behavior during COVID-19 in Taiwan: A qualitative study
Authors: Lee Tuan-he , Jarupreechachan Weerachaya , Tseng Yuan-Chi 
Published: October 2022

Background COVID-19 pandemic is reported to exacerbate existing vulnerabilities of marginalized groups, and the lack of self-care can lead to the spread of the virus across society. Therefore, effective responses to the challenges imposed by the health crisis should consider the health information needs of migrant workers. Objective We aimed to explore how migrant low-income workers seek health information and how their health-related information needs were met during a health crisis. We also investigated migrant workers’ preferred information sources and types of content with the theoretical concept of health literacy to understand the development of health competencies among migrant workers. Methods We conducted semi-structured interviews with Thai low-income migrant workers. A total of 13 Thai migrant workers participated in the study, among whom five were undocumented. The interviews were audio-taped, transcribed, and analyzed with the thematic analysis approach. Results Our findings indicated that migrant workers’ health literacy and health information behavior could be improved through technology when facing a health crisis. We found that participants sought health information proactively to reduce their perceived risks. However, there is still space for design to support the ability to process jargon information and apply local policy, such as providing easy-to-understand, accurate, and timely information. The findings of this study provide some insights for the authority and technological design to respond to migrant workers’ health information needs. Conclusions This study acknowledges and understands the needs of vulnerable migrant workers in society. The findings of this study provide insights for the authority and technological design to respond to migrant workers’ health information needs. We also outline the areas worth further investigation, such as the communication between information seekers and providers, and the navigation of the healthcare system for migrants in the host country.
Outcomes After Revision Fixation With Cement Augmentation for Failed Intertrochanteric Fracture Fixation in Older Adult Patients
Authors: Huyke-Hernández Fernando A. , Only Arthur J. , Sorich Megan , Onizuka Naoko , Switzer Julie A. , Cunningham Brian P. 
Published: October 2022

Introduction Intertrochanteric (IT) fractures that fail fixation are traditionally treated with arthroplasty, introducing significant risk of morbidity and mortality in frail older adult patients. Revision fixation with cement augmentation is a relatively novel technique that has been reported in several small scale international studies. Here we report a clinical series of 22 patients that underwent revision fixation with cement augmentation for IT fracture fixation failure. Methods This retrospective case series identified all patients that underwent revision intramedullary nailing from 2018 to 2021 at two institutions within a large metropolitan healthcare system. Demographics, injury characteristics, Charlson Comorbidity Index score, and surgical characteristics were extracted from the electronic medical record. Outcomes were extracted from the electronic medical record and included radiographic findings, pain, functional outcomes, complications, and mortality. Results Average follow-up after revision surgery was 15.2 ± 10.6 months. Twenty patients (90.9%) reported improved pain and achieved union or progressive healing after surgery. Most of these patients regained some degree of independent ambulation (19 patients, 86.4%), with only 5 patients (22.7%) requiring increased assistance for their activities of daily living (ADLs). One-year mortality was 13.6% (3 patients). Of the 5 patients (22.7%) that experienced complications, 2 patients (9.1%) required revision hemiarthroplasty for subsequent fixation failure. The other 3 patients did well when complications resolved. Conclusions Revision fixation with cement augmentation can be an effective, safe, cost-effective alternative to arthroplasty for the management of cases involving non-infected failed IT fracture fixation with implant cut-out or cut-through limited to the femoral head in older adult patients that have appropriate acetabular bone stock.
Safety and efficacy of atezolizumab with rituximab and CHOP in previously untreated diffuse large B-cell lymphoma
Authors: Younes Anas , Burke John M. , Cheson Bruce D. , Diefenbach Catherine S. , Ferrari Silvia , Hahn Uwe H. , Hawkes Eliza A. , Khan Cyrus , Lossos Izidore S. , Musuraca Gerardo , Tani Monica , Vitolo Umberto , Yuen Sam , Raval Aparna , Shivhare Mahesh , Nielsen Tina G. , Sellam Gila , Sharman Jeff P. 
Published: October 2022

Abstract
Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the current standard therapy for patients with diffuse large B-cell lymphoma (DLBCL) and is curative in ∼60% of patients. Atezolizumab is a humanized immunoglobulin G1 monoclonal antibody that targets programmed death–ligand 1 and has previously shown antitumor activity in several tumor types. In a phase 1b/2 trial (NCT02596971), we evaluated the safety and efficacy of atezolizumab in combination with R-CHOP (atezo–R-CHOP; for 6-8 cycles) in patients with previously untreated DLBCL. Patients achieving a complete response (CR) at the end of induction received consolidation therapy with atezolizumab on day 1 of each 21-day cycle for an additional 17 cycles. Overall, 42 patients with DLBCL were included in this analysis. The primary endpoint, CR rate at the end of induction, as assessed by an independent review committee (modified Lugano 2014 criteria), was 77.5% (95% confidence interval [CI], 64.0-87.7; n = 40). Investigator-assessed progression-free survival and overall survival at 3 years were 77.4% (95% CI, 59.7-88.0) and 87.2% (95% CI, 71.9-94.5), respectively. All treated patients experienced ≥1 adverse event (AE; 32 patients [76.2%] had grade 3-4 AE). One patient had a fatal AE (unconfirmed progressive multifocal leukoencephalopathy) that was considered related to atezolizumab and rituximab, and 17 patients (40.5%) experienced atezolizumab-related AEs of special interest. In previously untreated patients with DLBCL, atezo–R-CHOP demonstrated encouraging clinical efficacy and a safety profile consistent with the known toxicities of the individual drugs. This trial was registered at www.clinicaltrials.gov as #NCT02596971.
Transporter-dependent uptake and metabolism of myocardial interstitial serotonin in the rat heart
Authors: Sonobe Takashi , Akiyama Tsuyoshi , Pearson James T. 
Published: October 2022

AbstractTo investigate the roles of the serotonin (5-HT) transporter (SERT) and plasma membrane monoamine transporter (PMAT) in 5-HT uptake and its metabolism in the heart, we monitored myocardial interstitial levels of 5-HT and 5-HIAA, a metabolite of 5-HT by monoamine oxidase (MAO), in anesthetized rats using a microdialysis technique. Fluoxetine (SERT inhibitor), decynium-22 (PMAT inhibitor), or their mixture was locally administered by reverse-microdialysis for 60 min. Subsequently, pargyline (MAO inhibitor) was co-administered. Fluoxetine rapidly increased dialysate 5-HT concentration, while decynium-22 gradually increased it. The mixture induced a larger increase in dialysate 5-HT concentration compared to fluoxetine or decynium-22 alone. Fluoxetine increased dialysate 5-HIAA concentration, and this increase was abolished by pargyline. Decynium-22 and the mixture did not change dialysate 5-HIAA concentration, which were not affected by pargyline. Both SERT and PMAT regulate myocardial interstitial 5-HT levels by its uptake; however, 5-HT uptake via PMAT leads to 5-HT metabolism by MAO.
Comparison of anther transcriptomes in response to cold stress at the reproductive stage between susceptible and resistant Japonica rice varieties
Authors: Guo Zhenhua , Ma Wendong , Cai Lijun , Guo Tao , Liu Hao , Wang Linan , Liu Junliang , Ma Bo , Feng Yanjiang , Liu Chuanxue , Pan Guojun 
Published: October 2022

Abstract
Background
Rice is one of the most important cereal crops in the world but is susceptible to cold stress (CS). In this study, we carried out parallel transcriptomic analysis at the reproductive stage on the anthers of two Japonica rice varieties with contrasting CS resistance: cold susceptible Longjing11 (LJ11) and cold resistant Longjing25 (LJ25).

Results
According to the obtained results, a total of 16,762 differentially expressed genes (DEGs) were identified under CS, including 7,050 and 14,531 DEGs in LJ25 and LJ11, respectively. Examining gene ontology (GO) enrichment identified 35 up- and 39 down-regulated biological process BP GO terms were significantly enriched in the two varieties, with ‘response to heat’ and ‘response to cold’ being the most enriched. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified 33 significantly enriched pathways. Only the carbon metabolism and amino acid biosynthesis pathways with down-regulated DEGs were enriched considerably in LJ11, while the plant hormone signal transduction pathway (containing 153 DEGs) was dramatically improved. Eight kinds of plant hormones were detected in the pathway, while auxin, abscisic acid (ABA), salicylic acid (SA), and ethylene (ETH) signaling pathways were found to be the top four pathways with the most DEGs. Furthermore, the protein-protein interaction (PPI) network analysis identified ten hub genes (co-expressed gene number ≥ 30), including six ABA-related genes. Various DEGs (such as OsDREB1A, OsICE1, OsMYB2, OsABF1, OsbZIP23, OsCATC, and so on) revealed distinct expression patterns among rice types when the DEGs between LJ11 and LJ25 were compared, indicating that they are likely responsible for CS resistance of rice in cold region.

Conclusion
Collectively, our findings provide comprehensive insights into complex molecular mechanisms of CS response and can aid in CS resistant molecular breeding of rice in cold regions.
De novo transcriptome profiling unveils the regulation of phenylpropanoid biosynthesis in unripe Piper nigrum berries
Authors: Sreekumar Sweda , Divya Kattupalli , Joy Nisha , Soniya E. V. 
Published: October 2022

Abstract
Background
Black pepper (Piper nigrum L.) is rich in bioactive compounds that make it an imperative constituent in traditional medicines. Although the unripe fruits have long been used in different Ayurvedic formulations, the mechanism of gene regulation resulting in the production of the bioactive compounds in black pepper is not much investigated. Exploring the regulatory factors favouring the production of bioactive compounds ultimately help to accumulate the medicinally important content of black pepper. The factors that enhance the biosynthesis of these compounds could be potential candidates for metabolic engineering strategies to obtain a high level production of significant biomolecules.

Results
Being a non-model plant, de novo sequencing technology was used to unravel comprehensive information about the genes and transcription factors that are expressed in mature unripe green berries of P. nigrum from which commercially available black pepper is prepared. In this study, the key gene regulations involved in the synthesis of bioactive principles in black pepper was brought out with a focus on the highly expressed phenylpropanoid pathway genes. Quantitative real-time PCR analysis of critical genes and transcription factors in the different developmental stages from bud to the mature green berries provides important information useful for choosing the developmental stage that would be best for the production of a particular bioactive compound. Comparison with a previous study has also been included to understand the relative position of the results obtained from this study.

Conclusions
The current study uncovered significant information regarding the gene expression and regulation responsible for the bioactivity of black pepper. The key transcription factors and enzymes analyzed in this study are promising targets for achieving a high level production of significant biomolecules through metabolic engineering.
How can clinicians choose between conflicting and discordant systematic reviews? A replication study of the Jadad algorithm
Authors: Lunny C , Thirugnanasampanthar Sai Surabi , Kanji S , Ferri N , Pieper D , Whitelaw S , Tasnim S , Nelson H , Reid EK , Zhang Jia He , Kalkat Banveer , Chi Yuan , Abdoulrezzak Reema , Zheng Di Wen , Pangka Lindy R.S. , Wang Dian , Safavi Parisa , Sooch Anmol , Kang Kevin T. , Tricco Andrea C, 
Published: October 2022

Abstract
Introduction
The exponential growth of published systematic reviews (SRs) presents challenges for decision makers seeking to answer clinical, public health or policy questions. In 1997, an algorithm was created by Jadad et al. to choose the best SR across multiple. Our study aims to replicate author assessments using the Jadad algorithm to determine: (i) if we chose the same SR as the authors; and (ii) if we reach the same results.

Methods
We searched MEDLINE, Epistemonikos, and Cochrane Database of SRs. We included any study using the Jadad algorithm. We used consensus building strategies to operationalise the algorithm and to ensure a consistent approach to interpretation.

Results
We identified 21 studies that used the Jadad algorithm to choose one or more SRs. In 62% (13/21) of cases, we were unable to replicate the Jadad assessment and ultimately chose a different SR than the authors. Overall, 18 out of the 21 (86%) independent Jadad assessments agreed in direction of the findings despite 13 having chosen a different SR.

Conclusions
Our results suggest that the Jadad algorithm is not reproducible between users as there are no prescriptive instructions about how to operationalise the algorithm. In the absence of a validated algorithm, we recommend that healthcare providers, policy makers, patients and researchers address conflicts between review findings by choosing the SR(s) with meta-analysis of RCTs that most closely resemble their clinical, public health, or policy question, are the most recent, comprehensive (i.e. number of included RCTs), and at the lowest risk of bias.
Prescription characteristics associated with fall-related injury risk among older adults prescribed benzodiazepines: a cohort study
Authors: Maust Donovan T. , Bohnert Amy S. B. , Strominger Julie , Alexander Neil , Min Lillian , Hoffman Geoffrey J. , Goldstick Jason E. 
Published: October 2022

Abstract
Background
Benzodiazepines (BZD) are widely prescribed to older adults despite their association with increased fall injury. Our aim is to better characterize risk-elevating factors among those prescribed BZD.

Methods
A retrospective cohort study using a 20% sample of﻿ Medicare beneficiaries with Part D prescription drug coverage. Patients with a BZD prescription (“index”) between 1 April 2016 and 31 December 2017 contributed to incident (n=379,273) and continuing (n=509,634) cohorts based on prescriptions during a 6-month pre-index baseline. Exposures were index BZD average daily dose and days prescribed; baseline BZD medication possession ratio (MPR) (for the continuing cohort); and co-prescribed central nervous system-active medications. Outcome was a treated fall-related injury within 30 days post-index BZD, examined using Cox proportional hazards adjusting for demographic and clinical covariates and the dose prescribed.

Results
Among incident and continuing cohorts, 0.9% and 0.7% experienced fall injury within 30 days of index. In both cohorts, injury risk was elevated immediately post-index among those prescribed the lowest quantity: e.g., for <14-day fill (ref: 14-30 days) in the incident cohort, risk was 37% higher the 10 days post-fill (adjusted hazard ratio [HR] 1.37 [95% confidence interval [CI] 1.19-1.59]). Risk was elevated immediately post-index for continuing users with low baseline BZD exposure (e.g., for MPR <0.5 [ref: MPR 0.5-1], HR during days 1-10 was 1.23 [CI 1.08-1.39]). Concurrent antipsychotics and opioids were associated with elevated injury risk in both cohorts (e.g., incident HRs 1.21 [CI 1.03-1.40] and 1.22 [CI 1.07-1.40], respectively; continuing HRs 1.23 [1.10-1.37] and 1.21 [1.11-1.33]).

Conclusions
Low baseline BZD exposure and a small index prescription were associated with higher fall injury risk immediately after a BZD fill. Concurrent exposure to antipsychotics and opioids were associated with elevated short-term risk for both incident and continuing cohorts.
Tuberculosis treatment adherence in the era of COVID-19
Authors: Lippincott Christopher K. , Perry Allison , Munk Elizabeth , Maltas Gina , Shah Maunank 
Published: October 2022

Abstract
Background
In-person directly observed therapy (DOT) is commonly used for tuberculosis (TB) treatment monitoring in the US, with increasing usage of video-DOT (vDOT). We evaluated the impact of COVID-19 on TB treatment adherence, and utilization and effectiveness of vDOT.

Methods
We abstracted routinely collected data on individuals treated for TB disease in Baltimore, Maryland between April 2019 and April 2021. Our primary outcomes were to assess vDOT utilization and treatment adherence, defined as the proportion of prescribed doses (7 days/week) verified by observation (in-person versus video-DOT), comparing individuals in the pre-COVID and COVID (April 2020) periods.

Results
Among 52 individuals with TB disease, 24 (46%) received treatment during the COVID-19 pandemic. vDOT utilization significantly increased in the COVID period (18/24[75%]) compared to pre-COVID (12/28[43%], p = 0.02). Overall, median verified adherence was similar pre-COVID and COVID periods (65% versus 68%, respectively, p = 0.96). Adherence was significantly higher overall when using vDOT (median 86% [IQR 70–98%]) compared to DOT (median 59% [IQR 55-64%], p < 0.01); this improved adherence with vDOT was evident in both the pre-COVID (median 98% vs. 58%, p < 0.01) and COVID period (median 80% vs. 62%, p = 0.01).

Conclusion
vDOT utilization increased during the COVID period and was more effective than in-person DOT at verifying ingestion of prescribed treatment.