bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors
Authors: Pudakalakatti Shivanand , Titus Mark , Enriquez José S. , Ramachandran Sumankalai , Zacharias Niki M. , Shureiqi Imad , Liu Yi , Yao James C. , Zuo Xiangsheng , Bhattacharya Pratip K. 
Published: January 2022

Peroxisome proliferator-activated receptor delta (PPARD) is a nuclear receptor known to play an essential role in regulation of cell metabolism, cell proliferation, inflammation, and tumorigenesis in normal and cancer cells. Recently, we found that a newly generated villin-PPARD mouse model, in which PPARD is overexpressed in villin-positive gastric progenitor cells, demonstrated spontaneous development of large, invasive gastric tumors as the mice aged. However, the role of PPARD in regulation of downstream metabolism in normal gastric and tumor cells is elusive. The aim of the present study was to find PPARD-regulated downstream metabolic changes and to determine the potential significance of those changes to gastric tumorigenesis in mice. Hyperpolarized [1-13C] pyruvate magnetic resonance spectroscopy, nuclear magnetic resonance spectroscopy, and liquid chromatography-mass spectrometry were employed for metabolic profiling to determine the PPARD-regulated metabolite changes in PPARD mice at different ages during the development of gastric cancer, and the changes were compared to corresponding wild-type mice. Nuclear magnetic resonance spectroscopy-based metabolomic screening results showed higher levels of inosine monophosphate (p = 0.0054), uracil (p = 0.0205), phenylalanine (p = 0.017), glycine (p = 0.014), and isocitrate (p = 0.029) and lower levels of inosine (p = 0.0188) in 55-week-old PPARD mice than in 55-week-old wild-type mice. As the PPARD mice aged from 10 weeks to 35 weeks and 55 weeks, we observed significant changes in levels of the metabolites inosine monophosphate (p = 0.0054), adenosine monophosphate (p = 0.009), UDP-glucose (p = 0.0006), and oxypurinol (p = 0.039). Hyperpolarized [1-13C] pyruvate magnetic resonance spectroscopy performed to measure lactate flux in live 10-week-old PPARD mice with no gastric tumors and 35-week-old PPARD mice with gastric tumors did not reveal a significant difference in the ratio of lactate to total pyruvate plus lactate, indicating that this PPARD-induced spontaneous gastric tumor development does not require glycolysis as the main source of fuel for tumorigenesis. Liquid chromatography-mass spectrometry-based measurement of fatty acid levels showed lower linoleic acid, palmitic acid, oleic acid, and steric acid levels in 55-week-old PPARD mice than in 10-week-old PPARD mice, supporting fatty acid oxidation as a bioenergy source for PPARD-expressing gastric tumors.
Formación de valores en el Licenciado en Educación, Economía. Experiencias en la Universidad de Holguín
Authors: Almarales Fernández Mariela , Sánchez Arencibia Alba , Laguna Cruz Jorge Alejandro 
Published: January 2022

El objetivo del trabajo fue presentar algunas experiencias sobre la formación de valores a través de la obra de Ernesto Guevara en estudiantes de la Licenciatura en Educación, Economía, de la Universidad de Holguín, a partir del trabajo pedagógico, con base en el currículo, así como fortalecer el trabajo metodológico de los colectivos de carrera, año y disciplinas, teniendo en cuenta la precisión de los contenidos de dicha obra y su concreción en la práctica educativa. En la investigación se utilizaron métodos del nivel teórico y empírico. Entre los teóricos: la revisión documental, el analítico-sintético e inductivo-deductivo. Como empíricos, la observación, el pre experimento pedagógico, la entrevista, la encuesta, la técnica proyectiva de completamiento de frases, y la triangulación. Los principales resultados se evidencian en las transformaciones logradas en los modos de actuación de los estudiantes y su impacto positivo en la sociedad. Esto se manifiesta en los egresados de la carrera que se insertan en las instituciones de Educación Técnica y Profesional desempeñándose como docentes guías y otros cargos directivos. Como conclusiones, los autores afirman que las experiencias presentadas constituyeron una salida para cumplir con el encargo social de la profesión, dado el potencial del modelo del profesional y el plan de estudio.
Rise in prescribing for anxiety in UK primary care between 2003 and 2018: a population-based cohort study using Clinical Practice Research Datalink
Authors: Archer Charlotte , MacNeill Stephanie J , Mars Becky , Turner Katrina , Kessler David , Wiles Nicola 
Published: January 2022

BackgroundLittle is known about trends in prescribing of anxiolytics (antidepressants, benzodiazepines, beta-blockers, anticonvulsants, and antipsychotics) for treatment of anxiety. Several changes may have affected prescribing in recent years, including changes in clinical guidance.AimTo examine trends in prescribing for anxiety in UK primary care between 2003 and 2018.Design and settingA population-based cohort study using Clinical Practice Research Datalink (CPRD) data.MethodAnalysis of data from adults (n = 2 569 153) registered at CPRD practices between 2003 and 2018. Prevalence and incidence rates were calculated for prescriptions of any anxiolytic and also for each drug class. Treatment duration was also examined.ResultsBetween 2003 and 2018, prevalence of any anxiolytic prescription increased from 24.9/1000 person-years-at-risk (PYAR) to 43.6/1000 PYAR, driven by increases in those starting treatment, rather than more long-term use. Between 2003 and 2006, incidence of any anxiolytic prescription decreased from 12.8/1000 PYAR to 10.0/1000 PYAR; after which incidence rose to 13.1/1000 PYAR in 2018. Similar trends were seen for antidepressant prescriptions. Incident beta-blocker prescribing increased over the 16 years, whereas incident benzodiazepine prescriptions decreased. Long-term prescribing of benzodiazepines declined, yet 44% of prescriptions in 2017 were longer than the recommended 4 weeks. Incident prescriptions in each drug class have risen substantially in young adults in recent years.ConclusionRecent increases in incident prescribing, especially in young adults, may reflect better detection of anxiety, increasing acceptability of medication, or an earlier unmet need. However, some prescribing is not based on robust evidence of effectiveness, may contradict guidelines, and there is limited evidence on the overall impact associated with taking antidepressants long term. As such, there may be unintended harm.
PERLINDUNGAN HAK NARAPIDANA WANITA YANG MENGANDUNG DI LAPAS KELAS II B CIANJUR
Authors: Subroto Mitro , Sukmawijaya Agung 
Published: January 2022

ABSTRAKSistem Pemasyarakatan adalah upaya pembinaan yang dilaksanakan di Lembaga pemasyarakatan di Indonesia, pembinaan tersebut ditujukan bagi warga binaan yang melakukan tindak pidana dan dijatuhi hukuman penjara. Dalam proses pembinaan tersebut warga binaan diayomi dan dibina oleh petugas pemasyarakatan dan dilindungi hak-haknya sebagai warga negara. Dalam pelaksanaan peraturan-peraturan yang memuat ide-ide pemasyarakatan, maupun di dalam pelaksanaan Undang-undang Pemasyarakatan aparat pelaksana menjalankan tugas berdasarkan peraturan yang berlaku, di mana dalam kondisi tertentu aparat pelaksana mengambil keputusan-keputusan yang disesuaikan dengan kondisi dan situasi, agar ide-ide pemasyarakatan tersebut tetap dapat terwujud. Dalam pelaksanaan peraturan-peraturan tersebut banyak kendala-kendala yang menghambat terwujudnya tujuan pemasyarakatan. Kenadala-kendala tersebut ada yang dikarenakan keberadaan undang-undang itu sendiri, Dalam peraturan perundang-undangan khususnya dalam Undang-undang Nomor 12 tahun 1995 tentang Pemasyarakatan, ternyata masalah perlindungan hukum terhadap narapidana wanita belum diatur. Karena dalam undang-undang tersebut hanya disebutkan narapidana saja, tidak dibedakan antara narapidana laki-laki maupun Wanita. Sehingga perlu ditelaah ulang bagaimana Undang-Undang Pemasyarakatan melindungi hak-hak terhadap narapidana wanita khususnya bagi yang sedang mengandung. ABSTRACTThe Correctional System is a coaching effort carried out in correctional institutions in Indonesia, the guidance is intended for inmates who commit criminal acts and are sentenced to prison. In the coaching process, the inmates are protected and nurtured by correctional officers and their rights are protected as citizens. In the implementation of regulations that contain correctional ideas, as well as in the implementation of the Correctional Law, the implementing officers carry out their duties based on the applicable regulations, where under certain conditions the implementing officers make decisions that are adapted to the conditions and situations, so that ideas the correctional idea can still be realized. In the implementation of these regulations, there are many obstacles that hinder the realization of the correctional goals. These obstacles are caused by the existence of the law itself. In the legislation, especially in Law Number 12 of 1995 concerning Corrections, it turns out that the problem of legal protection for female prisoners has not been regulated. Because the law only mentions convicts, it does not differentiate between male and female prisoners. So it is necessary to review how the Correctional Law protects the rights of female prisoners, especially those who are pregnant.
PEMILIHAN KEPALA DAERAH DALAM PERSPEKTIF INDONESIA SEBAGAI NEGARA DEMOKRASI PANCASILA
Authors: Erita Rozalinda 
Published: January 2022

AbstrakKedaulatan rakyat dan demokrasi perlu ditegaskan dengan pelaksanaan Pemilihan Gubernur, Bupati, dan Walikota secara langsung oleh rakyat, dengan melakukan beberapa perbaikan mendasar atas berbagai permasalahan pemilihan langsung yang selama ini telah dilaksanakan, dengan perspektif Indonesia sebagai negara Demokrasi Pancasila. Penelitian bersifat deskriptif analitis dengan metode pendekatan yuridis normatif. Teknik pengumpulan data dengan cara penelitian kepustakaan yang kemudian dianalisis secara kualitatif. Penulis menghasilkan Model Pilkada Pancasilais sehingga Pilkada langsung dapat dilaksanakan dengan memperhatikan kaidah-kaidah yang termaktub dalam Pancasila. AbstractThe people's sovereignty and democracy need to be emphasized by the direct election of Governors, Regents, and Mayors by the people, by making some basic improvements to various problems of direct elections that have been carried out so far, with the perspective of Indonesia as a Pancasila Democracy country. The research is descriptive analytical with a normative juridical approach. Data collection techniques by means of library research which is then analyzed qualitatively. The author produces a Pancasilaist Pilkada Model so that direct elections can be carried out by paying attention to the rules contained in Pancasila.
ФЕНОМЕН ЖІНОЧОГО МИСТЕЦТВА СКУЛЬПТОРКИ ПРОПЕРЦІЇ ДЕ РОССІ У КУЛЬТУРІ ЧИНКВЕЧЕНТО БОЛОНЬЇ
Authors: Гончарова Олена 
Published: January 2022

На основі антропоцентричного підходу до аналізу візуальних самопрезентацій Проперції де Россі у творах скульптури, які виступають й засобами пізнання сутності людини, представлено художню творчість як феномен культури чинквеченто Болоньї. Проведене дослідження не лише надає інформацію про «авторську особистість» скульпторки, але й дають вихід на стереотипи соціуму певної історичної доби.
Використано низку методів історичного дослідження: біографічний, історико-хронологічний, історико-порівняльний. До них додано іконографічний та іконологічний методи. Наукова новизна полягає в авторській методиці аналізу творів образотворчого мистецтва з точки зору антропоцентричного підходу, а також розгляді генези та іконографії художньої творчості Проперції де Россі у стилістиці М. Раймонді, Рафаеля, Мікеланджело, що породжує нову культурну реальність.
Заперечено стереотип щодо другорядності мистецтва, створеного жінками. Встановлено, що соціалізація жінки скульпторки в культурі чинквеченто Болоньї відбувалася складніше, ніж чоловіка. Значний вплив на культурний розвиток Болоньї і жінок-мисткинь здійснював Болонський університет (1088 р.), у якому дозволялося вчитися жінкам. З’ясовано, що більш успішною у професії мисткині могла стати черниця у монастирі, або донька художника у майстерні батька. Вдома жінці дозволяли брати уроки рисування і живопису, займатися різьбленням, але коли це ставало її професією, вона потребувала маркетингу, комерціалізації свого мистецтва, шукала замовників та меценатів серед нобілітету, долаючи їхній скептицизм та отримуючи меншу грошову оплату, ніж художники-чоловіки. Твори цієї скульпторки уособлювали філософію її жіночого мистецтва, пов’язаного з релігійною тематикою. Її соціальне становище підвищувалося і наближалося до соціального статусу гуманістичної інтелігенції, ніж до статусу ремісниці культури чинквеченто в Болоньї.
CYBER VULNERABILITY OF JAPANESE BANKING/FINANCIAL SYSTEM
Authors: Davtyan Anna 
Published: January 2022

This study discusses the cyber vulnerability of Japanese Banking System and possible correlation with aging and considerably, less financial technologies educated population. As for 2020 there were taking place many major events regarding financial system databases leaked and in case Dokomo NTT Docomo Inc., the nation’s largest mobile phone carrier, about ¥28 million has been stolen from bank accounts linked to an e-money service operated by NTT Docomo Inc. When many of victims were not aware of their accounts connection to the NTT Docomo.
As nowadays we use financial services online more frequently, it should be given more attention to customer awareness of possible cyber crimes and warn them appropriately.
EXPLORATORY RESEARCH ON THE RELATIONSHIP BETWEEN DIGITAL SERVICE SUPPLY CHAIN CAPABILITY AND SUPPLY CHAIN PERFORMANCE
Authors: Ji Yuan 
Published: January 2022

Cross-border e-commerce (CBEC) has developed rapidly in the recent years, with continuous formation of new patterns in international and domestic double cycle development in the post-epidemic era. CBEC will be playing a more important role and undertake the task of foreign trade transformation and driving domestic economic growth. In this case, the corresponding service supplies chain capability（SSCC）becomes a key part of whether the CBEC platform could complete the task. Based on the grounded theory, this research has collected data through interviews with the relevant people working in the supply chain department of the CBEC platform to systematically explore the key factors behind dynamic service capability of the digital supply chain within the CBEC platform service ability. Then, the author constructs the theoretical model of the Digital Service Supply Chain Capability. The results show that the CBEC digital service supply chain capability consists of the logistics, capital flows and information flows. Data analysis includes internal data and external data, while internal data consists of the three main categories — customer demand forecast, product quality prediction and internal data collection & analysis. Finally, external data consists of the three main categories: market intelligence collection, assessing supplier risks and big data.
On-chip leakage current variation measurement using external-reference-free current-to-time conversion for densely placed MOSFETs
Authors: Islam Mahfuzul , Harada Shogo 
Published: January 2022

Abstract
This paper proposes a time-domain leakage current measurement circuit that uses an external-reference-free current-to-time conversion. Our proposed current-to-time converter (CTC) utilizes a dual inverter-based conversion to provide a stable reference. We share the CTC among the devices under test (DUTs) for accurate characterization of variation. Our CTC, along with a tree-based switch structure, allows us to densely place and route the DUT transistors using a cell-based design flow similar to a digital circuit design. We demonstrate our circuit by measuring subthreshold leakage currents of 256 minimum sized nMOSFETs in a 65 nm bulk low-power CMOS process. We could successfully extract the variations in subthreshold coefficient and subthreshold leakage current at different temperatures. Our circuit is also robust to supply voltage fluctuation making the circuit suitable for accurate characterization of MOSFET parameters for subthreshold operation.
Solution-processed light-emitting diodes consisting of metal-oxide and organic–inorganic hybrid emissive thin films
Authors: Kasuga Ryota , Tachibana Misato , Ohtani Naoki 
Published: January 2022

Abstract
We prepared organic–inorganic hybrid emissive thin films using a simple sol-gel method containing an emissive polymer for improving the operating lifetime of organic materials. The hybrid films can be developed using a precursor solution of tetraethoxysilane (TEOS) and an emissive polymer. In the films, the emissive polymer is encapsulated in SiO2 and not exposed to the atmosphere, thus improving the photoluminescence lifetime of the hybrid films with this sealing effect. We also prepared vanadium pentoxide (V2O5) thin films using a vanadium(V) oxytriisopropoxide (VTIP) precursor solution for application to hole-injection layers in light-emitting diodes (LEDs). The fabricated LEDs consisting of a solution-processed bilayer (hybrid and V2O5) showed improved operating lifetime. These results clearly demonstrate that a good sealing effect on the emissive polymer can be realized in hybrid films using a simple sol-gel method and that V2O5’s hygroscopicity and strong acidity are better than those of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS).
Even-denominator fractional quantum Hall state in conventional triple-gated quantum point contact
Authors: Hayafuchi Yasuaki , Konno Ryota , Noorhidayati Annisa , Fauzi Mohammad Hamzah , Shibata Naokazu , Hashimoto Katsushi , Hirayama Yoshiro 
Published: January 2022

Abstract
The even-denominator states have attracted considerable attention owing to their possible applications in future quantum technologies. In this letter, we first report a 3/2 diagonal resistance, indicating the existence of a 3/2 state in a nanometer-sized triple-gated quantum point contact (QPC) fabricated on a high-mobility (not ultra-high-mobility) single-layer two-dimensional (2D) GaAs wafer. The center gate plays a crucial role in realizing the QPC’s 3/2 state. Our observation of the 3/2 state using a conventional QPC device, which is a suitable building block for semiconductor quantum devices, paves a new path for the development of semiconductor-based quantum technologies.
أثر القواعد الفقهية في حماية الوقف
Authors: الحريري إبراهيم , العيساوي إسماعيل 
Published: January 2022

سعى الباحثان في هذا العمل إلى إظهار أثر القواعد الفقهية في حماية الوقف، وبيان أثرها في الحفاظ على أصل الوقف، وكان ما سبق الهدفَ الأسمى للبحث، وبدأ التمهيد بالتعريف بالمواضيع ذات الصلة، فقسّم الباحثان عملهما إلى مبحثين: فأما المبحث الأول، فسلّط الضوء على طرق حماية الوقف بما يجري عليه من التصرفات، وكيف ساهمت القواعد الفقهية القائمة على المصلحة، الممهورة بفقه المآل في ضمان سلامة أصل الوقف من عوارض الزمن، ولم يكن ذلك فحسب، بل تشبث البحث بالقواعد الفقهية التي تنظر في فقه التوقع وتغليب الاقتضاء التبعي على الاقتضاء الأصلي، وأما المبحث الثاني، فهو في وسائل حماية الوقف عند تعرض الوقف للزوال، القائم على القواعد الفقهية القائمة على فتح الذرائع، والتي تشهد بتقديم المصلحة الراجحة على المفسدة المتوقعة الكامنة، وكان بارزاً إعمال القواعد الفقهية في ترجيح المقاصد الشرعية للوقف على الوسائل، وختم البحث بذكر الخاتمة والنتائج ومن أهمّها :مشروعية مخالفة شرط الواقف بتقديم العمارة على المستحقين، وجواز بيع الوقف واستبداله بإذن القاضي ومشورة أهل الخبرة، ووجوب الادخار من الغلة للعمارة بقدر الحاجة، وذيّل البحث بتوصياتٍ، ومن أهمّها: إعمال مبدأ المرونة في الأعيان الموقوفة تماشياً مع مبدأ المصلحة، وتفعيل دور أهل الخبرة في مسائل الوقف.
Pengaruh Daun Binahong (Anredera cordifolia) terhadap Kadar Kolesterol Darah Tikus Wistar (Rattus norvegicus) Hiperkolesterolemia
Authors: Dewajanti Anna Maria , Limanto Agus , Taslim Yanfrin 
Published: January 2022

Aterosklerosis adalah penyakit kardiovaskuler yang menempati urutan pertama penyebab mortalitas dan morbiditas global. Penyakit ini ditandai dengan perubahan pada dinding pembuluh darah arteri yaitu terjadi penebalan dan kekakuan. Salah satu faktor penyebab terjadinya aterosklerosis adalah mengkonsumsi makanan berlemak dan tinggi kolesterol. Daun Binahong (Anredera cordifolia (Ten.)Steenis) dipercaya oleh masyarakat dapat menurunkan kadar kolesterol. Untuk mendapatkan zat dan bahan aktifnya maka daun binahong dibuat dalam bentuk ekstrak. Pada penelitian ini daun binahong diekstrak dalam etanol 96% dan untuk pengukuran kadar kolesterol total digunakan easy touch GCU. Penelitian ini menggunakan hewan coba tikus putih (Rattus norvegicus). Tikus dibagi menjadi 4 kelompok yaitu kelompok tikus hiperkolesterolemia tanpa perlakuan (kontrol), kelompok tikus hiperkolesterolemia dengan pemberian simvastatin (kontrol positif), kelompok tikus hiperkolesterolemia dengan pemberian ekstrak daun binahong (1.000 mg/kgbb dan 1.500 mg/kgbb). Dari hasil uji statistik disimpulkan bahwa pemberian ekstrak daun binahong 1.500 mg/kgbb memiliki efek dalam penurunan kadar kolesterol total darah secara signifikan pada hari ke-14.
Hubungan Kelelahan Kerja dengan Sif Kerja pada Petugas Keamanan
Authors: William  , Rumiati Flora , Antoni Marcel , Agustina Wahyu Ari 
Published: January 2022

Kelelahan kerja merupakan salah satu permasalahan kesehatan dan keselamatan kerja yang dapat menjadi faktor risiko terjadinya kecelakaan kerja. Risiko kelelahan kerja akan meningkat pada pekerja yang menjalankan sif kerja. Penelitian ini bertujuan untuk mengetahui hubungan antara sif kerja dengan kelelahan kerja pada petugas keamanan di Universitas X. Penelitian ini menggunakan pendekatan cross sectional. Responden adalah petugas keamanan yang melakukan sif pagi dan sif malam. Pengukuran kelelahan kerja objektif menggunakan waktu reaksi dan subjektif dengan kuesioner alat ukur perasaan kelelahan kerja (KAUPK2). Digunakan uji statistik Kolmogorov-Smirnov untuk melihat hubungan sif kerja dengan kelelahan kerja. Didapatkan 73,33% petugas keamanan sif pagi, dan 66,67% sif malam berusia dewasa. Sebanyak 80% sif pagi dan 80% sif malam berstatus sudah menikah. Petugas sif pagi 56,67% memiliki masa kerja baru, dan 76,67% petugas keamanan sif malam memiliki masa kerja lama. Sebanyak 50% responden sif pagi, dan 56,66 sif malam dalam kategori berat badan lebih. Selama menjalankan sif kerja, 60% responden sif pagi dan 83,33% sif malam tertidur di jam bertugas. Di dapatkan nilai p > 0,05 untuk perbedaan kelelahan kerja objektif dan subjektif pada petugas keamanan sif pagi dan sif malam. Dapat disimpulkan tidak terdapat hubungan antara kelelahan kerja dengan sif kerja petugas keamanan di Universitas X.
Identifying Teaching Writing Strategies Used by English Teachers at SMK N 3 Singaraja During Remote Teaching
Authors: Handayani Ni Nengah Diah , Suputra Putu Eka Dambayana , Juniarta Putu Adi Krisna 
Published: January 2022

The current study was carried out to identify the teaching writing strategies in remote teaching setting. This study was a case study. The study was conducted at SMK N 3 Singaraja. The participants of the current study were X grade English teachers of the 2020-2021 academic year, which consist of four teachers (2 females and 2 males). In conducting the study, observation and interview guide were used. The data were analyzed with guidance of analyzing qualitative data by Miles, Huberman, & Saldana (2014). The findings showed that the teaching writing strategies implemented by English teachers were guided writing, mind mapping, scaffolding, and dictogloss. In this remote teaching setting, English teachers are encouraged to be more creative in designing instruction and carrying the teaching strategies for teaching writing. Further study is suggested to identify teaching strategies used by English teacher in remote teaching for different language skills.