bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized, double-blinded, placebo-controlled, single dose analgesic study of preoperative intravenous ibuprofen for tonsillectomy in children
Authors: Cui Xiaohuan , Zhang Jianmin , Gao Zhengzheng , Sun Lan , Zhang Fuzhou 
Published: August 2022

PurposeTonsillectomy is a recognized treatment for children with tonsil hypertrophy and results in significant postoperative oropharyngeal pain. Fentanyl and other morphine-like analgesics are widely used as perioperative analgesia but are associated with side effects such as vomiting, nausea, and respiratory depression. As the least toxic non-steroidal anti-inflammatory drug, ibuprofen may be effective and safe for pain control after tonsillectomy. We aimed to explore whether the addition of intravenous (IV) ibuprofen administered at induction can reduce the need for early postoperativeanalgesics.Study design and methodsThis randomized, double-blind, controlled clinical trial enrolled 95 pediatric patients who underwent tonsillectomy. Participants aged 6 months to 12 years were randomly assigned to either the experimental and control groups (1:1). The children were premedicated 15 min before surgery with IV ibuprofen 10 mg kg−1 or placebo (normal saline). Pain was scored at 15, 30, and 120 min after extubation, and IV fentanyl (0.5 mcg kg−1) was administered when the Faces, Legs, Activity, Cry, and Consolability (FLACC) Scale was ≥7 and deemed appropriate by the nursing staff in the post-anesthesia care unit (PACU). The visual analog scale was used as a supplementary evaluation for older children (≥7 years old) who were awake and could self-report pain. The primary outcome variable was the number of patients who received postoperative analgesia.ResultsThe requirement for rescue fentanyl was reduced by 18% with the addition of IV ibuprofen (P = 0.043). There were no signficant differences in the amount of fentanyl administered postoperatively (P = 0.127). Compared with the placebo group, the number of children who needed more than one dose of rescue fentanyl decreased in the experimental group, but the differences were not significant (P = 0.056). There were no significant differences between the groups in terms of operative blood loss (P = 0.978), vomiting, or postoperative bleeding (P = 0.474).ConclusionIt is safe to administer IV ibuprofen 15 min before tonsillectomy, and it can significantly reduce the need for rescue fentanyl. IV ibuprofen should be considered as an important part of the multimodal approach for postoperative analgesia in children.Clinical trial registrationChictr.org.cn, identifier: ChiCTR2100044508.
Steviol glycosides as an alternative osmotic agent for peritoneal dialysis fluid
Authors: Kopytina Valeria , Pascual-Antón Lucía , Toggweiler Nora , Arriero-País Eva-María , Strahl Lisa , Albar-Vizcaíno Patricia , Sucunza David , Vaquero Juan J. , Steppan Sonja , Piecha Dorothea , López-Cabrera Manuel , González-Mateo Guadalupe-Tirma 
Published: August 2022

Background: Peritoneal dialysis (PD) is a renal replacement technique that requires repeated exposure of the peritoneum to hyperosmolar PD fluids (PDFs). Unfortunately, it promotes alterations of the peritoneal membrane (PM) that affects its functionality, including mesothelial-mesenchymal transition (MMT) of mesothelial cells (MCs), inflammation, angiogenesis, and fibrosis. Glucose is the most used osmotic agent, but it is known to be at least partially responsible, together with its degradation products (GDP), for those changes. Therefore, there is a need for more biocompatible osmotic agents to better maintain the PM. Herein we evaluated the biocompatibility of Steviol glycosides (SG)-based fluids.Methods: The ultrafiltration and transport capacities of SG-containing and glucose-based fluids were analyzed using artificial membranes and an in vivo mouse model, respectively. To investigate the biocompatibility of the fluids, Met-5A and human omental peritoneal MCs (HOMCs) were exposed in vitro to different types of glucose-based PDFs (conventional 4.25% glucose solution with high-GDP level and biocompatible 2.3% glucose solution with low-GDP level), SG-based fluids or treated with TGF-β1. Mice submitted to surgery of intraperitoneal catheter insertion were treated for 40 days with SG- or glucose-based fluids. Peritoneal tissues were collected to determine thickness, MMT, angiogenesis, as well as peritoneal washings to analyze inflammation.Results: Dialysis membrane experiments demonstrated that SG-based fluids at 1.5%, 1%, and 0.75% had a similar trend in weight gain, based on curve slope, as glucose-based fluids. Analyzing transport capacity in vivo, 1% and 0.75% SG-based fluid-exposed nephrectomized mice extracted a similar amount of urea as the glucose 2.3% group. In vitro, PDF with high-glucose (4.25%) and high-GDP content induced mesenchymal markers and angiogenic factors (Snail1, Fibronectin, VEGF-A, FGF-2) and downregulates the epithelial marker E-Cadherin. In contrast, exposition to low-glucose-based fluids with low-GDP content or SG-based fluids showed higher viability and had less MMT. In vivo, SG-based fluids preserved MC monolayer, induced less PM thickness, angiogenesis, leukocyte infiltration, inflammatory cytokines release, and MMT compared with glucose-based fluids.Conclusion: SG showed better biocompatibility as an osmotic agent than glucose in vitro and in vivo, therefore, it could alternatively substitute glucose in PDF.
Alleviating insomnia should decrease the risk of irritable bowel syndrome: Evidence from Mendelian randomization
Authors: Bao Wenzhao , Qi Li , Bao Yin , Wang Sai , Li Wei 
Published: August 2022

Background: Associations have been reported between sleep and irritable bowel syndrome (IBS). However, whether there exists a causation between them is still unknown.Methods: We employed the Mendelian randomization (MR) design to explore the causal relationship between sleep and IBS. All genetic associations with sleep-related traits reached genome-wide significance (p-value &lt; 5 × 10-8). The genetic associations with IBS were obtained from two independent large genome-wide association studies (GWAS), where non-FinnGen GWAS was in the discovery stage and FinnGen GWAS was in the validation stage. Primarily, the inverse-variance weighted method was employed to estimate the causal effects, and a meta-analysis was performed to combine the MR estimates.Results: In the discovery, we observed that genetic liability to the “morning” chronotype could lower the risk of IBS [OR = 0.81 (0.76, 0.86)]. Also, the genetic liability to insomnia can increase the risk of IBS [OR = 2.86 (1.94, 4.23)] and such causation was supported by short sleep duration. In the validation stage, only insomnia displayed statistical significance [OR = 2.22 (1.09, 4.51)]. The meta-analysis suggested two genetically-determined sleep exposures can increase the risk of IBS, including insomnia [OR = 2.70 (1.92, 3.80)] and short sleep duration [OR = 2.46 (1.25, 4.86)]. Furthermore, the multivariable MR analysis suggested insomnia is an independent risk factor for IBS after adjusting for chronotype [OR = 2.32 (1.57, 3.43)] and short sleep duration [OR = 1.45 (1.13, 1.85)]. IBS cannot increase the risk of insomnia in the reverse MR analysis.Conclusion: Genetic susceptibility to insomnia can increase the risk of IBS, and improving sleep quality, especially targeting insomnia, can help to prevent IBS.
Modulation of Leukocyte Subsets Mobilization in Response to Exercise by Water Immersion Recovery
Authors: Ottone Vinícius de Oliveira , De Paula Fabrício , Brozinga Paula Fernandes Aguiar , Matos Mariana Aguiar de , Duarte Tamiris Campos , Costa Karine Beatriz , Garcia Bruna Caroline Chaves , Silva Thyago José , Magalhães Flavio De Castro , Coimbra Cândido Celso , Esteves Elizabethe Adriana , Pinto Kelerson Mauro de Castro , Amorim Fabiano Trigueiro , Rocha-Vieira Etel 
Published: August 2022

Purpose:To investigate the effect of different water immersion temperatures on the kinetics of blood markers of skeletal muscle damage and the main leukocyte subpopulations.Methods:Eleven recreationally trained young men participated in four experimental sessions consisting of unilateral eccentric knee flexion and 90 min of treadmill running at 70% of peak oxygen uptake, followed by 15 min of water immersion recovery at 15, 28 or 38°C. In the control condition participants remained seated at room temperature. Four hours after exercise recovery, participants completed a performance test. Blood samples were obtained before and immediately after exercise, after immersion, immediately before and after the performance test and 24 h after exercise. The number of leukocyte populations and the percentage of lymphocyte and monocytes subsets, as well as the serum activity of creatine kinase and aspartate aminotransferase were determined.Results:Leukocytosis and increase in blood markers of skeletal muscle damage were observed after the exercise. Magnitude effect analysis indicated that post-exercise hot-water immersion likely reduced the exercise-induced lymphocytosis and monocytosis. Despite reduced monocyte count, recovery by 38°C immersion, as well as 28°C, likely increased the percentage of non-classical monocytes in the blood. The percentage of CD25+cells in the CD4 T cell subpopulation was possibly lower after immersion in water at 28 and 15°C. No effect of recovery by water immersion was observed for serum levels of creatine kinase and aspartate aminotransferase.Conclusions:Recovery by hot-water immersion likely attenuated the leukocytosis and increased the mobilization of non-classical monocytes induced by a single session of exercise combining resistance and endurance exercises, despite no effect of water immersion on markers of skeletal muscle damage. The monocyte response mediated by hot water immersion may lead to the improvement of the inflammatory response evoked by exercise in the skeletal muscle.
Efecto del aislamiento por la COVID-19 en el comportamiento de compra y lealtad de marca en los mexicanos
Authors: Fischer Laura , López-Celis Diana María , Peñalosa Mónica Eugenia , Larios-Gómez Emigdio 
Published: August 2022

El impacto de la COVID-19 se ha sentido de inmediato, debido a las diferentes acciones que los gobiernos han implantado en sus países, situación que ya persiste por la aparición de diferentes mutaciones del virus que ha causado durante casi dos años graves y profundos impactos económicos, políticos, sociales y psicológicos, El confinamiento a lo que ha sido sometida la población, ha traído consigo cambios en las conductas de los individuos, en la compra y consumo de productos y a la lealtad hacia las marcas
Teniendo como objetivo conocer los patrones de compra y lealtad de marca durante el confinamiento provocado por la pandemia de la COVID-19. Se realizó una investigación descriptiva con enfoque cuantitativo, a una muestra de 1004 sujetos, 64% mujeres y 36% hombres residentes en la República Mexicana, Evaluando para este fin, 3 dimensiones respecto al consumo: 1) aumento del consumo, 2) cambio de marca o cambio de hábitos y 3) continuidad en el consumo de las mismas marcas (lealtad); todas estas, durante la contingencia de la pandemia; lo cual conlleva a la lealtad de marca, considerando como categorías de primera necesidad en consumo, el hogar, los alimentos, los medicamentos, el cuidado personal, la higiene y la limpieza, Como hallazgos tenemos que existe una correlación de manera global, en todas las categorías de producto analizadas con respecto a las marcas consumida en época de confinamiento y la continuidad de ellas después del confinamiento, esta situación no se presenta igual en cada una de las categorías evaluadas, siendo la categoría de productos de limpieza la que muestra un mayor consumo y una menor lealtad a la marca en este mismo periodo
Risk Reducing of the Radiation-Induced Cardiovascular Damage in Patients with Breast Cancer
Authors: Демешко П.Д. 
Published: August 2022

Рак молочной железы (РМЖ) занимает ведущее место среди злокачественных новообразований у женского населения. За последние десятилетия в связи с совершенствованием методов диагностики и лечения отмечен значительный рост опухолево-специфической выживаемости. В частности, данные литературы демонстрируют эффективность проведения адъювантного курса лучевой терапии как компонента комплексного лечения РМЖ в отношении повышения локо-регионарного контроля заболевания. Вместе с тем с улучшением показателей выживаемости возрастает вероятность развития поздних осложнений лечения со стороны сердечно-сосудистой системы, негативно влияющих на качество жизни и ухудшающих прогноз общей выживаемости пациентов. В статье представлен обзор современных методик проведения ЛТ при РМЖ и возможности снижения риска развития радиационно-индуцированных повреждений сердечно-сосудистой системы.
Breast cancer (BC) is the leading malignant neoplasms in the female population. Over the past decades, due to the improvement of diagnostic and treatment methods, a significant increase in tumor-specific survival has been noted. In particular, literature data demonstrate the effectiveness of an adjuvant course of radiation therapy, as a component of the complex treatment of breast cancer, in terms of increasing the loco-regional control of the disease. At the same time, with the improvement of survival rates, the likelihood of developing late complications of treatment from the cardiovascular system increases, negatively affecting the quality of life and worsening the prognosis of the overall survival of patients. The article presents an overview of the state of modern methods of conducting RT in breast cancer and the possibility of reducing the risk of developing radiation-induced damage to the cardiovascular system.
Experience in the diagnosis and treatment of multiple neuroendocrine tumor of the stomach
Authors: Маевская Т.В. , Слободин Ю.В. 
Published: August 2022

Нейроэндокринные опухоли желудка (НЭОЖ) представляют собой новообразования, происходящие из энтерохромаффиноподобных гистаминсекретирующих клеток (ECL клеток) слизистой оболочки желудка.НЭОЖ подразделяются на три типа, каждый из которых имеет важные различия с точки зрения клинической картины, прогноза и тактики лечения, от типа нейроэндокринных опухолей (НЭО) зависит выбор методики эндоскопического или хирургического лечения образования.В статье представлен опыт эндоскопического и хирургического отделений ГУ «Республиканский клинический медицинский центр» Управления делами Президента Республики Беларусь (ГУ «РКМЦ») в диагностике и лечении множественной НЭОЖ 1-го типа на примере клинического случая, когда вместо стандартного при данном типе НЭО эндоскопического лечения возникла необходимость применения хирургического лечения.
Neuroendocrine tumors of the stomach (NETS) are neoplasms derived from enterochromaffin-like histamine-secreting cells (ECL cells) of the gastric mucosa. There are three types of NETS. Each type of NETS has important differences in terms of the clinical picture, prognosis and treatment tactic. The type of neuroendocrine tumor (NET) determines the choice of methods for endoscopic or surgical treatment of the mass.The article presents a clinical case of treatment of NETS type 1 in the endoscopic and surgical departments of the Republican Clinical Medical Center of the Presidential Administration of the Republic of Belarus.
Trimetazidine as a Modifier of Chemotherapy-Induced Endothelium Homeostasis Disturbances
Authors: Авагимян А.А. , Кактурский Л.В. 
Published: August 2022

Введение. Настоящее исследование направлено на изучение взаимосвязи между эндотелиальной дисфункцией, кардиотоксичностью АС-режима химиотерапии и триметазидином опосредованной вазопротекции.Цель. Изучить вазотоксический потенциал AC-режима химиотерапии наряду с одновременной оценкой вазопротекторного потенциала триметазидина.Материалы и методы. Проведенное исследование характеризуется как фундаментальное, рандомизированное, контролируемое, экспериментальное, in vivo. С целью проведения экспериментальной работы было задействовано 80 инбредных крыс линии Wistar, которые были рандомно разделены на 4 равные группы. Модель эндотелиальной дисфункции была получена с использованием химиотерапевтического коктейля, состоящего из доксорубицина и циклофосфамида. В качестве вероятного стабилизатора функционирования эндотелия был выбран триметазидин. Курсовая дозировка доксорубицина составила 15 мг/кг, циклофосфамида – 150 мг/кг, а триметазидина – 42 мг/кг. Продолжительность эксперимента – 14 дней.Результаты. В рамках настоящего исследования оценены девиации эндотелина-1, оксида азота, а также факторов адгезии VCAM и ICAM, маркер воспаления – С-реактивный белок. Полученные данные показали, что триметазидин модифицировал усиление эндотелиальной дисфункции.Выводы: 1. АС-режим химиотерапии оказывает выраженное эндотелий-дискоординирующее воздействие. 2. Триметазидин обладает значимым вазопротекторным потенциалом.
Introduction. Our research was determined to investigate the link between endothelial dysfunction, AC-mode of chemotherapy and trimetazidine-driven vasoprotection.Purpose. To investigate the AC-mode of chemotherapy-induced endothelium dysfunction and rationality of TMZ prescription.Materials and methods. The conducted study is characterized as a fundamental, randomized, controlled, experimental in vivo study. To carry out the experimental work, 80 inbred Wistar rats were involved, which were randomly divided into 4 equal groups. A model of endothelial dysfunction was generated using a direct combination of doxorubicin and cyclophosphamide. Trimetazidine was used as a probable stabilizer of endothelial activity. Course dose of doxorubicin – 15 mg/kg, course dose of cyclophosphamide – 150 mg/kg, course dose of trimetazidine – 42 mg/kg. The duration of the experiment was 14 days.Results. Within the framework of this study, deviations of endothelin-1, nitric oxide, as well as adhesion factors VCAM and ICAM, and an inflammatory marker, C-reactive protein, were evaluated.Conclusions: 1. AC-mode of chemotherapy provide pronounced endothelium discoordinating impact. 2. TMZ has sufficient vasoprotective properties.
The Importance of Echocardiography in the Detection of Early Chronic Heart Failure in Elderly Patients
Authors: Агабабян И.Р. , Ярашева З.Х. , Насретдинова М.Т. 
Published: August 2022

Цель. Изучить состояние центральной гемодинамики у пациентов пожилого возраста по данным эхокардиографии с целью выявления доклинической фазы хронической сердечной недостаточности.Материалы и методы. В исследование включены пациенты в возрасте 65–75 лет (средний возраст 76,17±3,29 года), которым выполнено стентирование коронарных артерий после перенесенного инфаркта миокарда (40 человек), и пациенты, которые остались на стандартной терапии ишемической болезни сердца после перенесенного инфаркта миокарда (40 человек). Производилась оценка характера послеоперационных изменений эхокардиографических значений.Результаты. В ходе исследования обнаружено, что у лиц пожилого возраста, которым было проведено стентирование коронарных артерий, отмечается достоверное снижение фракции выброса левого желудочка по сравнению с группой пациентов, которые остались на стандартной терапии ишемической болезни сердца. У пациентов, перенесших инфаркт миокарда, которым проведено стентирование коронарных артерий, несмотря на сохранную систолическую функцию левого желудочка, величина фракции выброса левого желудочка была достоверно ниже, чем в группе сравнения.Заключение. Вопрос стентирования коронарных артерий у пациентов пожилого возраста должен тщательно обсуждаться, особенно когда имеется коморбидная патология. Необходимо проводить исследования, направленные на длительное наблюдение пациентов после чрескожного коронарного вмешательства, а также для подтверждения или исключения хронической сердечной недостаточности у всех пациентов изучить уровень натрийуретического пептида.
Purpose. To study the state of central hemodynamics in elderly patients according to echocardiography in order to identify the preclinical phase of chronic heart failure.Materials and methods. The study included patients aged 65–75 years (average age 76.17±3.29 years) who underwent coronary artery stenting after a myocardial infarction (40 patients) and patients who remained on standard therapy for coronary heart disease after a myocardial infarction (40 patients). The nature of postoperative changes in echocardiographic values was evaluated.Results. During the study, it was found that in elderly people who had coronary artery stenting, there was a significant decrease in the left ventricular ejection fraction compared to the group that remained on standard therapy for coronary HEART disease. In patients with myocardial infarction who underwent coronary artery stenting, despite the preserved systolic function of the left ventricle, the value of the left ventricular ejection fraction was significantly lower than in the comparison group.Conclusion. The issue of coronary artery stenting in elderly patients should be carefully discussed, especially when there is a comorbid pathology. It is necessary to conduct studies aimed at long-term follow-up of patients after per cutaneous intervention, as well as to confirm or exclude chronic heart failure, all patients should study the level of natriuretic peptide.
الصناعات الغذائية الأردنية في قرن: مراجعة
Authors: Amr Ayed , Abdullah Mai 
Published: August 2022

شهد قطاع الصناعات الغذائية كباقي القطاعات الاقتصادية الأخرى نموا متسارعا ليواكب التغيرات الديموغرافية والصناعية والزراعية والاجتماعية بشتى مناحيها خلال المئة سنة الفائتة منذ تأسيس المملكة الأردنية الهاشمية سنة 1921. فمن بدايات متواضعة تمثلت في منشآت بسيطة لتلبية متطلبات المستهلك من الإنتاج الزراعي المحفوظ بالطرق البسيطة والطبيعية الى شركات متطورة جدا تنتج منتجات متنوعة تغطي احتياجات السوق المحلي وتصدر الى العشرات من دول العالم.
تبرز أهمية الصناعات الغذائية بالإضافة لدورها في تحقيق الأمن الغذائي في دعمها لقطاع الزراعة الأردني لاعتمادها على المنتج الزراعي كمادة أولية، كذلك الأمر, فإن قطاع الصناعات الغذائية يوفر فرص عمل لنسبة عالية من العمالة المحلية الماهرة وغير الماهرة.
رافقت نهضة الصناعات الغذائية ودعمتها عدة عوامل منها التشريعات بمستوياتها المتنوعة التي سنتها الدولة لحماية المستهلك والمنتج وتوفير البيئة الاستثمارية المناسبة، وتوفر الأعداد الهائلة من المهندسين المؤهلين للعمل في مصانع الأغذية وإدارتها , وتطور البنية التحتية الضرورية لنمو القطاع التي تشمل الى جانب مقومات البنية التقليدية من مواصلات واتصالات وشبكة كهرباء ومياه تشمل بعض الصناعات الميكانيكية المتخصصة في إنتاج بعض آلات الأغذية وبعض المكونات ومنافذ التسويق والشركات الاستشارية المتخصصة في إدارة الجودة والمختبرات الصناعية في القطاعين العام والخاص.
غير أن هذا القطاع يعاني كبقية القطاعات الاقتصادية من عدد من المشاكل أهمها المنافسة من البضائع الأجنبية والاعتماد على المواد الأولية المستوردة وارتفاع كلفة مدخلات الإنتاج وبعض السياسات الاقتصادية المعيقة لنمو القطاع، ما يؤكد الحاجة الى المزيد من الدعم الحكومي. وبالرغم من كل هذه المعيقات فإن القطاع صامد ومستمر في النمو ومن المتوقع أن يتسارع نموه كما ونوعا في السنين القادمة ليبقى رافدا أساسياً للزراعة والصناعة. سنقوم في هذه الورقة ببحث أهم محطات تطور قطاع الصناعات الغذائية، بمناسبة المئوية الأولى لتأسيس المملكة، وإلقاء الضوء على خواصه ومشاكله ومواطن قوته وضعفه وكيف يمكننا تعظيم الاستفادة من التطورات التكنولوجية والديموغرافية التي من المتوقع حدوثها في السنين القادمة.