bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’être et le temps dans le Parménide et dans le Timée de Platon
Authors: Karfík F. 
Published: September 2022

Abstract
Two of Plato’s dialogues, the Parmenides and the Timaeus, deal explicitly with the relationship between being and time. The former builds on the assumption that whatever is must be temporal, while the latter makes being and time mutually exclusive. This paper begins by examining how the argument develops in the Parmenides, specifically in the corresponding sections 140e1-142a1 and 151e3-155e3 of the first and the second deductions of the dialectical exercise, as well as in the corollary to the second deduction at 155e4-157b5. It then compares this argument with the account of time given in Timaeus 37e6-39e2, which alludes to the account given in the Parmenides. In stressing the incompatibility of these two accounts, it highlights a remarkable feature they both share. Parmenides’ argument starts from the assumption that whatever is in time must be present, past or future, whether a process or a state resulting from a process. As he advances further in the game of Zenonian antilogies, however, he reduces the dimension of the present to a mere ‘now’, conceived of as a ‘stop’ in the process of becoming. In the corollary, he eventually removes the present from time the ‘instant’ in which a change between two mutually exclusive processes or states occurs. Timaeus, for his part, immediately rules out that the present is a temporal dimension, by restricting temporality to the past and the future. Thus, in both accounts, the present vanishes from time and temporal processes are made dependent on extratemporal conditions. However, Parmenides’ argument points to an extratemporal principle of indeterminacy allowing for change, while, for Timaeus, there are two extratemporal conditions for temporal processes, namely the being of the intelligible Forms, on the one hand, and a pre-cosmic, disorderly becoming in space, on the other.
Resisting to the Beat: Exploring the Theological and Educational Significance of Hip Hop as an Act of Resistance
Authors: Cloete Anita 
Published: September 2022

Abstract
The article wishes to explore the theological significance of Hip Hop as an everyday practice of resistance that warrants practical-theological reflection. The first section provides a short background of how Hip Hop came into existence and highlights its core elements, like the role of memory, resistance, social analysis, and critique in a local and global context. This is followed by an explanation of the practical-theological focus of the article. The second section offers a detailed discussion of the religious and theological value of Hip Hop, while the final section focuses on how this act of resistance provides a platform that could shape agency, especially among youth, and dissects the educational value of Hip Hop as cultural text. Considering the context and content of Hip hop, it is argued that it could be instrumental in being a voice for the voiceless and marginalised as an essential aspect of popular culture in contexts like South Africa and Brazil.
Italian Prisoners Who Died During and After the First World War: A Quantitative Assessment
Authors: Fornasin Alessio , Freni Giuliana 
Published: September 2022

Abstract
The number of Italian military prisoners who died in enemy hands stands, according to the Italian historiography on the First World War, at 100,000 or more. In this paper, we offer an alternative estimate of the number of deaths using both individual and aggregate data. The reconstruction distinguishes between soldiers who died in captivity and soldiers who died as a consequence of captivity during and after the war. The results demonstrate that the number 100,000 is too high. The correct number would be, for the period from 25 May 1915 to 31 December 1925, above 57,000 and probably lower than 73,000.
Functional changes in long-term incubated rat precision-cut lung slices
Authors: Nußbaum Sarah Marie , Krabbe Julia , Böll Svenja , Babendreyer Aaron , Martin Christian 
Published: September 2022

Abstract
Background
Respiratory diseases represent a global health burden. Because research on therapeutic strategies of airway diseases is essential, the technique of precision-cut lung slices (PCLS) has been developed and widely studied. PCLS are an alternative ex vivo model and have the potential to replace and reduce in vivo animal models. So far, the majority of studies was conducted with short-term cultivated PCLS (≤ 72 h). As there is large interest in research of chronic diseases and chronic toxicity, feasibility of cultivating human PCLS long-term over 2 weeks and recently over 4 weeks was investigated by another research group with successful results. Our aim was to establish a model of long-term cultivated rat PCLS over a period of 29 days.

Methods
Rat PCLS were cultured for 29 days and analysed regarding viability, histopathology, reactivity and gene expression at different time points during cultivation.

Results
Cultivation of rat PCLS over a 29-day time period was successful with sustained viability. Furthermore, the ability of bronchoconstriction was maintained between 13 and 25 days, depending on the mediator. However, reduced relaxation, altered sensitivity and increased respiratory tone were observed. Regarding transcription, alteration in gene expression pattern of the investigated target genes was ascertained during long-term cultivation with mixed results. Furthermore, the preparation of PCLS seems to influence messenger ribonucleic acid (mRNA) expression of most target genes. Moreover, the addition of fetal bovine serum (FBS) to the culture medium did not improve viability of PCLS. In contrast to medium without FBS, FBS seems to affect measurements and resulted in marked cellular changes of metaplastic and/or regenerative origin.

Conclusions
Overall, a model of long-term cultivated rat PCLS which stays viable for 29 days and reactive for at least 13 days could be established. Before long-term cultivated PCLS can be used for in-depth study of chronic diseases and chronic toxicity, further investigations have to be made.
Feasibility and acceptability of electronic EQ-5D-5L for routine measurement of HRQOL in patients with chronic musculoskeletal problems in Hong Kong primary care
Authors: Ng Amy Pui Pui , Liu Kiki Sze Nga , Cheng Will Ho Gi , Wong Carlos King Ho , Cheng John King Yiu , Lam Joyce Sau Mei , Or Calvin Kalun , Tse Emily Tsui Yee , Lam Cindy Lo Kuen 
Published: September 2022

Abstract
Background
Information on HRQOL can enhance patient diagnosis and management but it is rarely available in routine clinical practice. This mixed-method study evaluated the feasibility and acceptability of the electronic EQ-5D-5L measurement of HRQOL in patients with chronic musculoskeletal problems in primary care.

Methods
In three primary care clinics, 665 patients with musculoskeletal problems completed the electronic EQ-5D-5L and Visual Analogue Scale (e-EQ-5D-5L/VAS), and a questionnaire on socio-demographics, perceived ease of use (PEOU), and perceived usefulness (PU) at baseline and two follow-ups. Patient completion and response rates, and time to complete the e-EQ-5D-5L/VAS were measured. During the same consultations, 49 doctors reviewed the e-EQ-5D-5L/VAS reports and completed a clinician questionnaire on PEOU, PU, and time spent to address each report. Individual interviews along with focus group discussions were conducted on patients, doctors, and research assistants for further exploration.

Results
Mean completion time reduced from baseline to first and second follow-up (120.66, 83.99, and 105.22 s, respectively). Completion and response rates were high at each follow-up visit (> 99.8% and > 91.11%, respectively). Doctors needed less than 2 min to read the report but felt the time required to address the report was a significant barrier. Some patients had difficulties using e-platforms, in understanding or answering questions; but, PEOU improved with time (p < 0.001). Most patients found the e-platforms useful (> 85.3%). Clinicians agreed a great majority of the reports were easy to use (76.0–85.1%) and useful (69.2–72.0%), particularly aiding with a holistic view of the patient's musculoskeletal problem.

Conclusion
The e-EQ-5D-5L/VAS is a feasible and acceptable measurement of HRQOL of patients with chronic musculoskeletal problems in routine primary care in Hong Kong which can assist real-time management decisions.
Trial registration: NCT03609762.
The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors
Authors: Tosi Anna , Parisatto Beatrice , Menegaldo Anna , Spinato Giacomo , Guido Maria , Del Mistro Annarosa , Bussani Rossana , Zanconati Fabrizio , Tofanelli Margherita , Tirelli Giancarlo , Boscolo-Rizzo Paolo , Rosato Antonio 
Published: September 2022

Abstract
Background
Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- and second-line settings. However, only 15–20% of patients benefit from this treatment, a feature increasingly ascribed to the peculiar characteristics of the tumor immune microenvironment (TIME).

Methods
Immune-related gene expression profiling (GEP) and multiplex immunofluorescence (mIF) including spatial proximity analysis, were used to characterize the TIME of 39 treatment-naïve oropharyngeal squamous cell carcinomas (OPSCC) and the corresponding lymph node metastases. GEP and mIF results were correlated with disease-free survival (DFS).
HPV-positive tumors disclosed a stronger activation of several immune signalling pathways, as well as a higher expression of genes related to total tumor-infiltrating lymphocytes, CD8 T cells, cytotoxic cells and exhausted CD8 cells, than HPV-negative patients. Accordingly, mIF revealed that HPV-positive lesions were heavily infiltrated as compared to HPV-negative counterparts, with a higher density of T cells and checkpoint molecules. CD8+ T cells appeared in closer proximity to tumor cells, CD163+ macrophages and FoxP3+ cells in HPV-positive primary tumors, and related metastases. In HPV-positive lesions, PD-L1 expression was increased as compared to HPV-negative samples, and PD-L1+ tumor cells and macrophages were closer to PD-1+ cytotoxic T lymphocytes. Considering the whole cohort, a positive correlation was observed between DFS and higher levels of activating immune signatures and T cell responses, higher density of PD-1+ T cells and their closer proximity to tumor cells or PD-L1+ macrophages. HPV-positive patients with higher infiltration of T cells and macrophages had a longer DFS, while CD163+ macrophages had a negative role in prognosis of HPV-negative patients.

Conclusions
Our results suggest that checkpoint expression may reflect an ongoing antitumor immune response. Thus, these observations provide the rationale for the incorporation of ICI in the loco-regional therapy strategies for patients with heavily infiltrated treatment-naïve OPSCC, and for the combination of ICI with tumor-specific T cell response inducers or TAM modulators for the “cold” OPSCC counterparts.
Burnout syndrome among pediatric dentists in Egypt
Authors: Radwan Mohamed Zayed , Morsy Mahmoud 
Published: September 2022

Abstract
Background
Pediatric dentists in Egypt are exposed to chronic stress associated with pediatric dental care. After long years of specialization, training, and practice, they seem to be unsatisfied. An increased prevalence of burnout could be the reason. This study aimed to determine the prevalence of occupational burnout among Egyptian pediatric dentists.
This study is a cross-sectional, observational study, which was carried by a self-administered online survey questionnaire that was sent to active members in the Egyptian Pediatric Dentistry Associations. A total number of 100 pediatric dentists participated in this study. All of them were offered to fulfill the questionnaires including that of Maslach Burnout Inventory and the semi-structured questionnaire to complete their sociodemographic and work-related data.

Results
It was found that the number of kids raised up by the practitioner is significantly associated with the level of depersonalization. It was also found that the number of working hours per week and number of patients treated per day have a significant association with the level of exhaustion, depersonalization, and personal accomplishment. There were no gender differences in the prevalence of burnout or depression.

Conclusions
Burnout prevalence among pediatric dentist in Egypt is high and higher than its prevalence among other dentists. Marriage and sleeping in home with the family have protective effects against burnout statistically. There is significant association between high number of working hours of the pediatric dentist per week and burnout.
Postoperative hyponatremia in neonates with esophageal atresia and tracheoesophageal fistula receiving restricted hypotonic fluids
Authors: Dogra Shivani , Malik Muneer A. , Peters Nitin J. , Samujh Ram 
Published: September 2022

Abstract
Background
During the postoperative course following neonatal surgery, several stimuli like respiratory distress, pain, and stress cause the release of the antidiuretic hormone which can induce hyponatremia. This hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) in neonates can lead to neurologic impairment and in severe cases can cause significant morbidity and mortality. Lung involvement in neonates undergoing TEF makes this subset of patients vulnerable to this entity because most of them are sick and require ventilation in the postoperative period. The incidence of postoperative hyponatremia following neonatal surgery has not been studied vastly. To the best of our knowledge, this is the first prospective study that has analyzed the incidence of postoperative hyponatremia in this vulnerable population.

Methods
Prospective observational study to assess the incidence of postoperative hyponatremia in neonates with esophageal atresia and tracheoesophageal fistula (EA and TEF) receiving restricted hypotonic fluids. As per the unit policy N/4 5% D is given in the postoperative period. Most neonatal units follow a protocol in which fluid is hiked daily to reach 150 ml/kg/day in 5–7 days. However, in our neonatal surgical unit a protocol to restrict the maintenance fluid at 100 ml/kg/day irrespective of day of life is followed.

Results
Out of a total of 90 neonates (270 sodium measurements), we identified 16 with hyponatremia (11%). Most of the neonates had mild hyponatremia(130–135 meq/l). The incidence of moderate and severe hyponatremia was low.

Conclusion
Postoperative restriction of fluids especially in neonates who are at a high risk for developing SIADH can lead to decreased incidence of severe hyponatremia.
Progressive retinal degeneration of rods and cones in a Bardet-Biedl syndrome type 10 mouse model
Authors: Mayer Sara K. , Thomas Jacintha , Helms Megan , Kothapalli Aishwarya , Cherascu Ioana , Salesevic Adisa , Stalter Elliot , Wang Kai , Datta Poppy , Searby Charles , Seo Seongjin , Hsu Ying , Bhattarai Sajag , Sheffield Val C. , Drack Arlene V. 
Published: September 2022

ABSTRACT
Bardet-Biedl syndrome (BBS) is a multi-organ autosomal-recessive disorder caused by mutations in at least 22 different genes. A constant feature is early-onset retinal degeneration leading to blindness. Among the most common forms is BBS type 10 (BBS10), which is caused by mutations in a gene encoding a chaperonin-like protein. To aid in developing treatments, we phenotyped a Bbs10 knockout (Bbs10−/−) mouse model. Analysis by optical coherence tomography (OCT), electroretinography (ERG) and a visually guided swim assay (VGSA) revealed a progressive degeneration (from P19 to 8 months of age) of the outer nuclear layer that is visible by OCT and histology. Cone ERG was absent from at least P30, at which time rod ERG was reduced to 74.4% of control levels; at 8 months, rod ERG was 2.3% of that of controls. VGSA demonstrated loss of functional vision at 9 months. These phenotypes progressed more rapidly than retinal degeneration in the Bbs1M390R/M390R knock-in mouse. This study defines endpoints for preclinical trials that can be utilized to detect a treatment effect in the Bbs10−/− mouse and extrapolated to human clinical trials.
Neuromechanics of The Rate of Force Development
Authors: Del Vecchio Alessandro 
Published: September 2022

ABSTRACT
The rate at which an individual can develop force during rapid voluntary contractions can be influenced by both the neural drive to a muscle and its intrinsic musculotendinous properties. We hypothesize that the maximal rate of force development across human individuals is mainly attributable to the rate of motor unit recruitment.

Summary for table of contents

The rate of force development varies greatly across individuals. In the present review we discuss the neuromechanical factors that explain this variability.
Ketogenic Diets and Mitochondrial Function: Benefits for Aging but not for Athletes
Authors: Pathak Suraj J. , Baar Keith 
Published: September 2022

Abstract
As humans age, we lose skeletal muscle mass, even in the absence of disease (sarcopenia), increasing the risk of death. Low mitochondrial mass and activity contributes to sarcopenia. It is our hypothesis that, a ketogenic diet improves skeletal muscle mitochondrial mass and function when they have declined due to aging or disease, but not in athletes where mitochondrial quality is high.
Dentists’ perceptions on present and future dental practice during the COVID-19 pandemic: An embedded study
Authors: Shenoy Ramya , Das Deeksha , Mukherjee Megha , Baranya Shrikrishna Suprabha , Denny Ceena , D’Souza Violet 
Published: September 2022

Background: The emergence of the COVID-19 pandemic has placed a significant burden on everyone. Although dental professionals are at an increased risk of COVID-19 infection, currently, very little is known about how oral health professionals and their professions could be affected by the pandemic. This study aims to investigate dentists' perceptions on present and future dental practice in light of the COVID-19 pandemic. Methods: We conducted an embedded mixed-methods study at Manipal College of Dental Sciences, Mangalore, with Indian dentists registered with the Dental Council of India. Results: Of the 976 participating dentists, 61% were females, 32% were 40 years of age or younger. Nearly half of the respondents (54%) acknowledged that the lockdown measures caused them a severe financial burden, and 56% were seriously concerned about being a source of infection to their family, friends, and community. Although 79% felt very comfortable or somewhat comfortable going back to work, they were all worried that Personal Protective Equipment (PPE) use would increase their financial burden and impact the number of patients seeking care. Even though a vast majority received the necessary information regarding returning to practice from their concerned dental regulatory bodies, some were unsure about the reuse of the PPEs because of the conflicting information they received. Conclusion: The COVID-19 pandemic affected participants' professional lives negatively. Their major concerns were being a source of infection to their families and community. Providing information to dental professionals in a timely manner may prepare dentists to provide safe care to their patients while protecting themselves, their staff, and their families.
Paravertebral vs. Epidural Analgesia for Liver Surgery (PEALS): Protocol for a randomized controlled pilot study
Authors: Mizubuti Glenio B. , Ho Anthony M.-H. , DuMerton Deborah , Phelan Rachel , Hopman Wilma M. , Cheng Camilyn , Xiong Jessica , Shelley Jessica , Vowotor Elorm , Nanji Sulaiman , Jalink Diederick , Lima Lais Helena Navarro e 
Published: September 2022

Background: Perioperative thoracic epidural analgesia (TEA) is commonly used in hepatectomy patients since it is opioid-sparing and reduces cardiorespiratory complications. However, TEA has a high failure rate and is associated with potentially devastating complications (particularly spinal haematoma) and the risk is likely increased with hepatectomy. Thus, some centres favour systemic opioid-based modalities which, in turn, are associated with inferior analgesia and well-known risks/side-effects. Hence, alternative analgesic methods are desirable. Paravertebral block (PVB) has been used in liver resection with advantages including hemodynamic stability, low failure rates, and low risk of spinal haematoma. Our purpose is to conduct a blinded, pilot RCT with hepatectomy patients randomised to receive TEA or PVB for perioperative analgesia. Our hypothesis is that opioid consumption, time to first analgesic request, and pain scores will be comparable between groups, but PVB patients will require fewer perioperative vasopressors/blood products, and have fewer adverse events and a shorter hospital stay. Methods: With ethics approval, this non-inferiority, pilot RCT with a convenience sample of 50 hepatectomy patients will examine whether PVB imparts analgesia comparable to TEA but with fewer adverse effects. Primary outcomes are surrogates of analgesia for 72 h postoperatively (i.e., opioid consumption, time to first analgesic request and pain scores at rest and with coughing); Secondary outcomes are blood products/fluids administered; side effects/complications until 72 h postoperatively; length of hospital stay. The results will be used to plan a large multicentre trial comparing TEA vs. PVB in hepatectomy patients. This study has a high potential to positively impact the quality/safety of patient care. ClinicalTrials.gov registration: NCT02909322 (09-21-2016); Available at URL: https://clinicaltrials.gov/ct2/show/NCT0290932
Incorporating reading strategies for EFL undergraduate learners in Saudi Arabia: A think-aloud study
Authors: Al-Ahdal Arif Ahmed Mohammed Hassan , Alolaywi Yasamiyan 
Published: September 2022

Background: In language learning, reading is a skill that enables interaction with a text in whatever field of knowledge the learner is pursuing. Readers tend to use strategies such as comprehension, interpretation and conception of decoding written language and texts to enhance their reading capacity. This research explores the reading strategies applied by Saudi English as a Foreign Language (EFL) learners and compares the reading abilities of male and female EFL students. Methods: The study interviewed three EFL students about the reading strategies they applied while reading passages and texts. Then an International English Language Testing System (IELTS) reading test was handed over to 26 randomly selected students. Results: The study found that the reading strategies used by the students interviewed involved skimming, scanning, guessing the meaning from context, identifying the mean idea, and summarizing the body of the text in question. Moreover, the study revealed that both male and female students scored low in the IELTS tests that the researchers conducted. The average mean score they reached was 7.15 out of 20. However, even in the low scoring ratio, female students (M=7.69) outperformed male students (M= 6.62) and the difference between them remained significant, P=.000. Conclusions: The study recommends that the language instructors help EFL learners in developing their reading strategies and applying them every time they read any text.