bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-Base station hybrid positioning algorithm based on LOS identification
Authors: Gao Yang , Dou Xiaoyuan , Jiao Zihan , Fan Jiancun 
Published: November 2022

Abstract
In the complex and unknown positioning environment, the positioning effect is often not ideal. This paper proposes a single-base station (BS) hybrid positioning algorithm based on line-of-sight (LOS) identification, which improves the positioning accuracy in a complex and unknown positioning environment. We first use multiple features with significant differences in statistical distribution in the LOS environment and the not-line-of-sight (NLOS) environment, and combine with classification algorithms such as Gradient Boosting Decision Tree (GBDT), to determine whether there is a LOS path in the environment. Then we use different positioning methods in different positioning environments according to the LOS identification results, and achieve the purpose of improving positioning accuracy through hybrid positioning. For the environment with LOS path, the estimation of signal parameters via rotation invariant technology (ESPRIT) algorithm is used to jointly estimate the angle of arrival (AOA) and time delay of the LOS path, so as to realize the position estimation. For the environment where there is no LOS path, we propose a method to directly use the NLOS path for positioning. The advantage of this method is that it can meet the positioning of a single BS and can achieve relatively high positioning accuracy. Simulation results show that the proposed hybrid positioning algorithm can achieve high-precision positioning in the complex unknown positioning environment.
A pilot randomized controlled trial to assess the feasibility of a sham anti-inflammatory diet: Can inflammation neutrality and participant blinding be achieved?
Authors: Allison David J. , Agudelo Alexandria Roa , Lawson Arden , Gazzellone Giuseppe , Ditor David S. , Loh Eldon 
Published: November 2022

Abstract
Context: While randomized, double-blind, placebo-controlled trials are the gold standard for investigating the effects of dietary interventions, the complexity of designing such trials has limited their use.
Study Design: Single centre, randomized, double-blind, controlled trial.
Objective: Primary objectives included the assessment of the impact of a sham anti-inflammatory diet on inflammation and participant blinding.
Methods: This dietary advice trial involved participants with spinal cord injury (SCI), randomized to either a sham-diet condition (n=8) or non-dieting control condition (n=8). Participants in the sham-diet group were told they would be randomized to either an anti-inflammatory diet condition, or a sham diet designed to be inflammation-neutral. Participants randomized to the sham-condition completed a diet consultation prior to beginning the diet for a period of 4-weeks. Primary outcomes of interest included the change in inflammation as assessed by plasma concentrations of C-reactive protein (CRP), and participant blinding assessed upon completion of the trial.
Results: All members of the control group and 6 of 8 members of the sham-diet group completed the intervention. Blinding was successful as all 6 members who completed the sham-diet believed they were on the true anti-inflammatory diet. Further, the sham diet was shown to have no significant effect on inflammation over the 4-week intervention period as demonstrated by plasma CRP concentrations.
Conclusion: This pilot study provides preliminary evidence for the utility of a sham-anti-inflammatory diet and could be used to strengthen the design of future dietary interventions utilizing anti-inflammatory diets.
Incidence and clinical characteristics of adverse neurological events and stroke-like syndrome associated with immune stress-related response after COVID-19 vaccination
Authors: Sirisuk Wikawee , Limvorapitak Wasithep , Lolekha Praween , Methaset Kanthida , Kulkantrakorn Kongkiat 
Published: November 2022

Abstract
AEFIs (adverse events following immunizations) , especially ISRR ( immune stress related response ) which similar to stroke symptoms may affect the vaccine roll-out campaign to prevent the coronavirus 2019 outbreak. This study aimed to describe the incidence and clinical characteristics of neurological AEFIs and stroke-like syndrome associated with ISRR after COVID-19 vaccination. Characteristics of ISRR were compared to minor ischemic stroke patients during the same period of the study. During March to September 2021, we retrospectively collected data of participants aged ≥ 18 years who received COVID-19 vaccine and developed AEFIs from Thammasat university vaccination center (TUVC). Data of neurological AEFIs patients and minor ischemic stroke patients were collected from hospital electronic medical record system. COVID-19 vaccine were administered at TUVC for 245,799 doses. AEFIs were reported in 129,652 instances (52.6%). ChADOx-1 nCoV-19 viral vector vaccine has the most frequent occurrence of AEFIs (58.0%), and neurological AEFIs (12.6%). Of 119 patients who received COVID-19 vaccine from anywhere with neurological AEFIs and presented to TUH, ISRR was diagnosed in 107 patients (89.9%) and all patients who has follow-up data (30.8%) showed clinical improvement. In comparison with minor ischemic stroke (116 patients), ISRR patients had significantly less ataxia, facial weakness, weakness of arm/leg and speech disturbances (P < 0.001). In conclusion, the incidence of neurological AEFIs after COVID-19 vaccination was much higher among recipients of ChAdOx-1 nCoV-19 vaccine (12.6%) than inactivated vaccine (6.2%) and mRNA vaccine (7.5%). However, most neurological AEFIs were ISRR, had mild severity and resolved within 30 days. Stroke-like symptoms occurred significantly less than patients with minor ischemic stroke.
Lenalidomide Derivative and PROTAC for Controlling Neosubstrate Degradation
Authors: Sawasaki Tatsuya , Yamanaka Satoshi , Furihata Hirotake , Imai Yuuki , Yanagihara Yuta , Nagaoka Koya , Shoya Yuki , Yoshida Shuhei , Shibata Norio , Taya Akihito , Nagasaka Takato , Usui Mai , Kosako Hidetaka , Nishino Kohei , Miyakawa Takuya , Tanokura Masaru 
Published: November 2022

Abstract
Lenalidomide, an immunomodulatory drug (IMiD), is commonly used as first-line therapy in many haematological cancer diseases, such as multiple myeloma (MM) and 5q myelodysplastic syndromes (5q MDS), and it functions as a molecular glue for the protein degradation of neosubstrates by CRL4CRBN 1–4. Proteolysis-targeting chimeras (PROTACs) using IMiDs with a target protein binder also induce the degradation of target proteins5,6. The targeted protein degradation (TPD) of neosubstrates is crucial for IMiD therapy2–4,7. However, current IMiDs and IMiD-based PROTACs also unexpectedly break down neosubstrates involved in embryonic development and disease progression2–4,8–10. Here, we showed that 6-position modifications of lenalidomide are essential for controlling neosubstrate selectivity; 6-fluoro lenalidomide induced the selective degradation of IKZF1, IZKF3, and CK1α, which are involved in anti-haematological cancer activity2–4, and showed stronger antiproliferative effects on MM and 5q MDS cell lines than lenalidomide. PROTACs using the new lenalidomide derivatives for BET proteins induced the selective degradation of BET proteins with the same neosubstrate selectivity. PROTACs also exerted antiproliferative effects in all cell lines examined, including MM and neuroblastoma cell lines. Thus, 6-position-modified lenalidomide is a key strategy for selective TPD using thalidomide derivatives and PROTACs.
Spatiotemporal change and driving factors of ecological status in Inner Mongolia based on the modified remote sensing ecological index
Authors: Zongfan Bai , Ling Han , Huiqun Liu , Xuhai Jiang , Liangzhi Li 
Published: November 2022

Abstract

Remote sensing monitoring of regional ecological quality has advanced significantly with the rapid developments of remote sensing technology. At present, remote sensing ecological index (RSEI) has been widely used in ecological status monitoring. However, RSEI was proposed for urban environments, and the rationality and accuracy of its applicability to desert-dominated arid zone ecosystems need to be demonstrated. Therefore, in this study, we incorporated desertification monitoring index (DMI) and salinity monitoring index (SMI) to RSEI and developed the modified remote sensing ecological index (MRSEI) for arid regions. Moreover, we analyzed the stability of MRSEI in ecological status monitoring for arid regions. The MRSEI was then used to evaluate the ecological quality of Inner Mongolia from 2000 to 2020 and exploring its causes. The results show that (1) Although the evaluation results of RSEI and MRSEI are more consistent in areas with high ecological status grades, the MRSEI results are more cautious and reliable in extreme conditions (e.g., desertification, salinization) than the RSEI. (2) Approximately 87.66% of ecological quality have improved or remain stable from 2000 to 2020, but the remaining areas (accounting for 12.34% of the whole area) are still under degraded conditions. This demonstrates that although local governments have made some progress in ecological conservation, the areas that are fluctuating or degraded still require protection or management. (3) In Inner Mongolia, the ecological quality which drove by precipitation (P) & temperature (T) accounting for 26.67% of the study area, population density (D) and GDP per capita (G) affected 13.23% of regional ecological quality. Overall, this research is crucial for evaluating spatial and temporal changes in arid region ecology and establishing conservation strategies.
Anxiety, depression and perceived social support among covid-19 patients admitted to a Covid Care Centre in Uttarakhand, India
Authors: KHAN MOHD NAJMUL AQIB , MAROOF MOHD , . PREETI , Gupta Rupali , Naaz Azmi , Awasthi Sadhana 
Published: November 2022

Abstract
Background: Mental illnesses including depression and anxiety are very common across all age groups. Even individuals with minimal or undetectable COVID-19 symptoms have felt the effects of this burden, which the COVID-19 pandemic has intensified.
Methods: A cross-sectional study was conducted on 346 COVID-19 patients with asymptomatic or mild illness. Depression and anxiety were measured using the Hospital Anxiety and Depression Scale (HADS), and perceived social support was measured using the Multidimensional Scale of Perceived Social Support (MSPSP). Version 16 of SPSS was utilised to analyse the data. We employed ANOVA, Pearson's rank correlation, independent t-tests, and multivariate linear regression. P values less than 0.05 were considered statistically significant.
Results: 13.8 percent patients had comorbid depression and 32 percent, anxiety. 35.2 percent patients did not have enough support. Significant correlation between depression and anxiety, depression and social support, and anxiety and social support was observed. Regression analysis showed age, marital status, covid case in family, and hypertension had significant association with both anxiety and depression. Association of diabetes mellitus with anxiety was also observed. Perceived social support was found to be significantly associated with age, covid case in family, and presence of diabetes mellitus and hypertension.
Conclusion:Significant number of COVID-19 patients displayed signs of anxiety, depression and lack of social support. Clinico-social factors found associated with anxiety, depression and perceived social support should be better taken care of in a future crisis like COVID-19.
Identification of cuproptosis-related subtypes, the establishment of a prognostic model, and exploration of drug candidates in urothelial carcinoma
Authors: Wang Yanhao , Chen Yixin , Yang Wentao , Jin Shengming , Xu Pei-hang , Ye Dingwei , Shen Yijun 
Published: November 2022

Abstract
Background
Urothelial carcinoma (UC) originates from the urinary tract and can arise from the renal pelvis, ureter, urinary bladder, and urethra. This new kind of programmed cell death, called cuproptosis, is linked to tumor advancement and microenvironment homeostasis. Nevertheless, the biological functions of cuproptosis-related genes (CRGs) in UCs are yet unknown.
Methods
The three Gene Expression Omnibus datasets (GEO) datasets and The Cancer Genome Atlas (TGCA) database were utilized to obtain data from 972 UC patients. R software was utilized to identify different cancer clusters and comprehensively depicted their relationships with clinical pathological characteristics and tumor microenvironment.
Results
Firstly, 972 UC patients underwent classification to obtain three CRG clusters based on 17 prognostic CRGs, showing significantly different prognoses, clinical features, and immune infiltration statuses (P < 0.001). Specifically, we found that cluster C displayed more like an immune-inflamed phenotype and cluster B was more consistent with the immune-desert pattern. Also, three cuproptosis gene clusters were identified according to differentially expressed genes (DEGs), displaying significantly different prognoses (P < 0.001). Secondly, we developed and validated a cuproptosis risk model and the formula we utilized was: CRG_score = (-0.0887 * HSD17B2) + (0.2014 * KDELR3) + (0.1125* EFEMP1) + (0.1118 * TMEM45A). All samples were randomly divided into the training and validation sets, and the high-risk score group was strongly correlated with poor prognosis in both sets. Besides, the two risk groups displayed significant differences in the tumor microenvironment, mutation landscape, and anti-tumor agent sensitivity. Finally, a nomogram was constructed to predict individual risk, with AUC values of 0.78, 0.79, and 0.81 for 1-, 3-, and 5-year periods, correspondingly.
Conclusions
This study revealed the underlying biological patterns of cuproptosis-related genes in UC. We developed a CRG risk score that could act as a practical prognostic model to predict the clinical outcome of individual UC patients.
Patient Handoffs and Trainee Perspectives Across an Institution: A Mixed Methods Study Informing Best Practices and an Expanded Conceptual Framework for Handoffs
Authors: Williams Sarah R. , Sebok-Syer Stefanie S. , Caretta-Weyer Holly , Katznelson Laurence , Dohn Ann M. , Park Yoon Soo , Gisondi Michael A. , Tekian Ara 
Published: November 2022

Abstract
Background: Safe and effective physician-to-physician patient handoffs are integral to patient safety. Unfortunately, poor handoffs continue to be a major cause of medical errors. Developing a better understanding of challenges faced by health care providers is critical to address this continued patient safety threat. This study addresses the gap in the literature exploring broad, cross-specialty trainee perspectives around handoffs and provides a set of trainee-informed best practices for both training programs and institutions.
Methods: Using a constructivist paradigm, the authors conducted an explanatory-sequential mixed method study to investigate trainees’ experiences with patient handoffs across Stanford Health Care, a large academic medical center. The authors designed and administered a survey instrument including Likert-style and open-ended questions to solicit information about trainee experiences from multiple specialties. The authors performed a thematic analysis of open-ended responses.
Results: 687/1138 (60.4%) of residents and fellows responded to the survey, representing 46 training programs. There was wide variability in handoff content and process, most notably code status not being consistently mentioned a third of the time for patients who were not full code. Supervision and feedback about handoffs were inconsistently provided. Trainees identified multiple health-systems level issues that complicated handoffs and suggested solutions to these threats. Our thematic analysis identified five important aspects of handoffs: 1) handoff elements, 2) health-systems-level factors, 3) impact of the handoff, 4) agency (duty), and 5) blame and shame.
Conclusions: Health systems, interpersonal, and intrapersonal issues affect handoff communication. The authors propose an expanded theoretical framework for effective patient handoffs and provide a set of best practices that training programs and sponsoring institutions should implement to protect patient safety. Cultural and health-systems issues must be prioritized and addressed, as an undercurrent of blame and shame permeates the clinical environment.
Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands (11C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors
Authors: Cai Lisheng , Liow Jeih-San , Morse Cheryl L. , Telu Sanjay , Davies Riley , Manly Lester S. , Zoghbi Sami S. , Chin Frederick T. , Innis Robert B. , Pike Victor W. 
Published: November 2022

Abstract
We recently reported 11C-NR2B-SMe ([S-methyl-11C](R,S)-7-thiomethoxy-3-(4-(4-methyl-phenyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol) and its enantiomers as candidate radioligands for imaging the GluN2B subunit within rat N-methyl-D-aspartate receptors. However, these radioligands gave unexpectedly high and displaceable binding in rat cerebellum, possibly due to cross-reactivity with sigma-1 (σ1) receptors. This study investigated 11C-labeled enantiomers of a close analogue (7-methoxy-3-(4-(p-tolyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol; NR2B-Me) of 11C-NR2B-SMe as new candidate GluN2B radioligands. PET was used to evaluate these radioligands in rats and to assess potential cross-reactivity to σ1 receptors. Methods: NR2B-Me was assayed for binding affinity and selectivity to GluN2B in vitro. 11C-NR2B-Me and its enantiomers were prepared by Pd-mediated treatment of boronic ester precursors with 11C-iodomethane. Brain PET scans were conducted after radioligand intravenous injection into rats. Various ligands for GluN2B receptors or σ1 receptors were administered at set doses in pre-blocking or displacement experiments to assess their impact on imaging data. 18F-FTC146 and enantiomers of 11C-NR2B-SMe were used for comparison. Radiometabolites from brain and plasma were measured ex vivo and in vitro. Results: NR2B-Me enantiomers showed high NR2B affinity and selectivity in vitro. 11C-NR2B-Me enantiomers gave high early whole rat brain uptake of radioactivity, including high uptake in cerebellum, followed by slower decline. Radioactivity in brain at 30 minutes ex vivo was virtually all unchanged radioligand. Only less lipophilic radiometabolites appeared in plasma. When 11C-(R)-NR2B-Me was used, three high-affinity GluN2B ligands—NR2B-SMe, Ro25-6981, and CO101,244—showed increasing pre-block of whole brain radioactivity retention with increasing dose. Two σ1 receptor antagonists, FTC146 and BD1407, were ineffective pre-blocking agents. Together, these results strongly resemble those obtained with 11C-NR2B-SMe enantiomers, except that 11C-NR2B-Me enantiomers showed faster reversibility of binding. When 18F-FTC146 was used as a radioligand, FTC146 and BD1407 showed strong pre-blocking effects whereas GluN2B ligands showed only weak blocking effects. Conclusion: 11C-NR2B-Me enantiomers showed specific binding to GluN2B receptors in rat brain in vivo. High unexpected specific binding in cerebellum was not due to σ1 receptors. Additional investigation is needed to identify the source of the high specific binding.
Family physicians partnering for system change: A multiple-case study of Ontario Health Teams in development
Authors: Grady Colleen , Chan-Nguyen Sophy , Mathies David , Alam Nadia 
Published: November 2022

Abstract
Background
The Ontario Health Teams (OHT) model is a form of integrated care that seeks to provide coordinated delivery of care to communities across Ontario, Canada. Primary care is positioned at heart of the Ontario Health Teams model, yet physician participation and representation has been severely challenged at planning and governance tables.
Methods
The purpose of this multiple case study is to examine 1) processes and structures to enable family physician participation in OHTs and 2) describe prevalent challenges to family physician participation. We conducted semi-structured interviews with stakeholders (administrators, physicians) from OHT communities and carried out an analysis of internal and external documents to contextualize interview findings. Thematic analysis was first applied within case and then between cases.
Results
Four OHT communities participated in this study. Thirty-nine participants (17 family physicians; 22 other stakeholders) participated in the study. Over 60 documents were provided and analyzed. The study took place between June and December 2021.
Conclusions
Within-case analysis found that structures and processes should be formalized and established to facilitate physician participation. Skepticism, burnout, heavy workload, and the COVID-19 pandemic were challenges to participation. Between-case analysis found that participation varied amongst cases. Face-to-face communication processes were favoured in all cases and history of collaboration facilitated relationship-building. All cases faced similar challenges to physician participation despite regional differences.
Numerical investigation of vertical borehole heat exchanger heat transfer under coupled conditions of groundwater seepage and layered subsurface
Authors: Zhao Peng , Li Xiaozhao , Zhang Donghai , Lin Yungzhi , Zhang Ye , Ji Yukun 
Published: November 2022

Abstract
Vertical borehole heat exchangers (VBHEs) have been considered to be one of the best sustainable geotechnical technologies for building heating or cooling. In most of the current numerical models for the analysis of VBHE heat transfer, the assumption of subsurface homogeneity is considered. However, the actual subsurface presents a layered structure, and some aquifer groups have groundwater seepage. An improved numerical model is proposed that takes into account not only the coupled condition of groundwater seepage and the layered subsurface but also the heat transfer of VBHEs at different locations, including inside the borehole, borehole wall and outside the borehole. The model is further verified by comparing numerical predictions with in-situ experimental data. The heat transfer characteristic at these different locations under groundwater seepage and layered subsurface coupled condition is investigated. Moreover, the model is applied to investigate the thermal behaviors of VBHE arrays in two typical arrangements (matrix and staggered arrangement). Furthermore, the influence of groundwater seepage in different layers on the heat transfer ability of the VBHE is discussed. The results demonstrate that the model can comprehensively consider the influencing factors inside or outside the borehole, and can reflect the actual geological conditions of the VBHEs.