bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing word meanings in biomedical literature reveal pandemics and new technologies
Authors: Nicholson David N. , Alquaddoomi Faisal , Rubinetti Vincent , Greene Casey S. 
Published: June 2022

AbstractWhile we often think of words as having a fixed meaning that we use to describe a changing world, words are also dynamic and changing. Scientific research can also be remarkably fast-moving, with new concepts or approaches rapidly gaining mind share. We examined scientific writing, both preprint and pre-publication peer-reviewed text, to identify terms that have changed and examine their use. One particular challenge that we faced was that the shift from closed to open access publishing meant that the size of available corpora changed by over an order of magnitude in the last two decades. We developed an approach to evaluate semantic shift by accounting for both intra- and inter-year variability using multiple integrated models. Using this strategy and examining year-by-year changes revealed thousands of change points in both corpora. We found change points for tokens including ‘cas9’, ‘pandemic’, and ‘sars’ among many others. The consistent change-points between pre-publication peer-reviewed and preprinted text were largely related to the COVID-19 pandemic. We developed a web app for exploration (https://greenelab.github.io/word-lapse/) that enables users to investigate individual terms. To our knowledge, this analysis is the first to examine semantic shift in biomedical preprints and pre-publication peer-reviewed text, and it lays the foundation for future work to examine how terms acquire new meaning and the extent to which that process is encouraged or discouraged by peer review.
Use of statins and other lipid-modifying agents across pregnancy – a nationwide drug utilization study of 822 071 pregnancies in Norway in 2005-2018
Authors: Christensen Jacob J. , Bogsrud Martin P. , Holven Kirsten B. , Retterstøl Kjetil , Veierød Marit B. , Nordeng Hedvig 
Published: June 2022

AbstractBackgroundStatins are becoming more widely used among women of reproductive age; however, nationwide data on statin use across pregnancy is scarce. We therefore aimed to describe the drug utilization patterns for statins and other lipid-modifying agents (LMAs) before, during, and after pregnancy, for all pregnancies in Norway from 2005 to 2018.MethodsWe linked individual-level data from four nationwide electronic health care registries in Norway and characterized the prescription fills of statins and other LMAs across pregnancy. We also examined trends in pregnancy-related LMA use, and characterized women using statins and other LMAs on parameters of health status and co-morbidity.ResultsIn total 822 071 pregnancies for 503 723 women were included. The number of statin prescription fills decreased rapidly during first trimester and returned to pre-pregnancy levels about one year postpartum. Pregnancy-related statin use increased from 2005 (approx. 0.11 % of all pregnancies) to 2018 (approx. 0.29 % of all pregnancies); however, in total, few statin prescriptions were filled within any trimester of pregnancy (n = 331, 0.04 % of all pregnancies). Statin use was more common in women with higher age, higher weight, smoking, and comorbidities such as hypertension and diabetes mellitus; also, statin users often had co-medication pertinent to these conditions.ConclusionsAlthough statins and other LMAs were increasingly being used around the time of pregnancy among women in Norway, drug use was mostly discontinued during first trimester. Our results suggest that pregnancy-related statin use should be monitored, and that drug safety analyses for maternal and offspring health outcomes are needed.
DNA Methylation Age Acceleration, Type 2 Diabetes, and its Complications: Cross-sectional and Longitudinal Data from the Berlin Aging Study II (BASE-II)
Authors: Vetter Valentin Max , Spieker Johanne , Sommerer Yasmine , Buchmann Nikolaus , Kalies Christian Humberto , Regitz-Zagrosek Vera , Bertram Lars , Demuth Ilja 
Published: June 2022

AbstractPatients with diabetes mellitus are at risk for micro- and macrovascular complications that are responsible for a substantial part of the individual health burden and socio-economic costs. Therefore, implementable risk scores are needed to improve targeted prevention for patients that are particularly susceptible to complications. The “epigenetic clock” estimates an individual’s biological age using DNA methylation profiles and was previously shown to be associated with morbidity and mortality.In this study, we examine older adults of the BASE-II study that were reexamined on average 7.4 years after baseline assessment as part of the GendAge study. For DNA methylation age (DNAmA) estimation we used the 7-CpG clock which was available for two timepoints (n=1,071 at follow-up). In addition, we determined epigenetic age using Horvath’s clock, Hannum’s clock, PhenoAge and GrimAge which were available at follow-up only (n=1,067). The deviation of DNAmA from chronological age, DNA methylation age acceleration (DNAmAA), was calculated as residuals of a leukocyte cell count adjusted linear regression analysis. Diabetes associated complications were assessed with the Diabetes Complications Severity Index (DCSI).Cross-sectionally, a statistically significant association between oral glucose tolerance test results and Hannum (ß=0.8, SE=0.3, p=0.02, n=762) and PhenoAge DNAmAA (ß=0.8, SE=0.3, p=0.003, n=762) was found. PhenoAge was also associated with fasting glucose (ß=0.3, SE=0.1, p=0.013, n=966). In contrast, we observed no cross-sectional association after covariate adjustment between DNAmAA and a diagnosis of diabetes mellitus with any of the five clocks employed. This was true for longitudinal analyses with the 7-CpG clock as well. However, longitudinal analyses showed that every year in the 7-CpG-based DNAmAA estimate at baseline increased the risk for developing of one or more additional complications or worsening of an already existing complication during the follow-up period by 11% in male participants with diabetes mellitus type 2. This association persisted after adjustment for DCSI at baseline, chronological age, smoking, alcohol, diabetes medication, and BMI (OR =1.11, p=0.045, n=56). No statistically significant association was found in the subgroup of women or when the whole dataset was analyzed (p>0.05).Although our findings still need to be independently validated, the 7-CpG clock appears to be a promising biomarker which is informative about the individual risk for diabetic complications independent of age, sex, lifestyle factors, or complications at baseline.
Hospital Perinatal Transmission Dynamics of Antimicrobial Resistance, Bangladesh, 2020
Authors: Styczynski Ashley , Amin Mohammed Badrul , Parveen Shahana , Pervez Abu , Zeba Dilruba , Akhter Akhi , Pitchik Helen , Islam Mohammad Aminul , Hossain Muhammed Iqbal , Saha Sumita Rani , Gurley Emily S. , Luby Stephen 
Published: June 2022

AbstractAntimicrobial resistance (AMR) is a growing global health threat that contributes to substantial neonatal mortality. Bangladesh has reported some of the highest rates of AMR among bacteria causing neonatal sepsis. To better understand routes of AMR transmission to newborns, we aimed to characterize the frequency of and risk factors for AMR colonization of mothers and newborns during hospitalization for delivery. We enrolled 177 pregnant women presenting for delivery to a tertiary care hospital in Faridpur, Bangladesh, during February-October 2020. We collected vaginal and rectal swabs from mothers on presentation and after delivery as well as rectal swabs from newborns. We also collected swabs from the hospital environment proximal to the patients. Swabs were plated on chromogenic agars selective for extended-spectrum-beta-lactamase producing organisms (ESBL) and carbapenem-resistant organisms (CRO). We performed univariable and multivariable analyses to determine factors associated with ESBL/CRO colonization. Prior to delivery, 17% of mothers had vaginal colonization and 71% had rectal colonization with ESBLs; 4% had vaginal colonization and 13% had rectal colonization with CROs. Seventy-nine percent of women underwent cesarean deliveries (C-section). Ninety-eight percent of women received prophylactic antibiotics during hospitalization. Following delivery, nearly 90% of mothers and newborns were colonized with ESBLs and over 70% with CROs. Of the 290 environmental samples, 77% were positive for ESBLs, and 69% were positive for CROs. Maternal and newborn colonization at discharge were both associated with C-section (RR for maternal 1.4; 95% CI 1.0-1.8 and newborn 1.3; 95% CI 1.1-1.7). Facility-based deliveries increase exposure to AMR organisms, likely driven by intense use of antibiotics and frequent C-sections. Greater attention should be given to the use of perinatal antibiotics, indications for C-sections, and infection prevention practices to reduce the high prevalence of colonization with antibiotic resistant bacteria.
Early visual cortex tracks speech envelope in the absence of visual input
Authors: Bednaya Evgenia , Mirkovic Bojana , Berto Martina , Ricciardi Emiliano , Martinelli Alice , Federici Alessandra , Debener Stefan , Bottari Davide 
Published: June 2022

AbstractNeural entrainment to continuous speech is typically observed within the language network and can be modulated by both low-level acoustic features and high-level meaningful linguistic units (e.g., phonemes, phrases, and sentences). Recent evidence showed that visual cortex may entrain to speech envelope, however its putative role in the hierarchy of speech processing remains unknown. We tested blindfolded participants who listened to semantically meaningful or meaningless stories, either in quiet or embedded in multi-talker babble noise. Entrainment to speech was assessed with forward linear modeling of participants’ EEG activity. We investigated (1) low-level acoustic effects by contrasting neural tracking of speech presented in quiet or noise and (2) high-level linguistic effects by contrasting neural tracking to meaningful or meaningless stories. Results showed that envelope tracking was enhanced and delayed for speech embedded in noise compared to quiet. When semantic information was missing, entrainment to speech envelope was fastened and reduced. Source modeling revealed that envelope tracking engaged wide neural networks beyond the auditory cortex, including early visual cortex. Surprisingly, while no clear influence of semantic content was found, the magnitude of visual cortex entrainment was affected by low-level features. The decrease of sound SNR-level dampened visual cortex tracking, suggesting an active suppressing mechanism in challenging listening conditions. Altogether, these findings provide further evidence of a functional role of early visual cortex in the entrainment to continuous speech.
Enhancing value in healthcare: towards a trans-disciplinary approach
Authors: Maguire William , Murphy Lyn 
Published: June 2022

PurposeThe purpose of this paper is to suggest how decision-makers may work towards a broader perspective on value than that expressed in financial economics-based accounting terms to enhance value in healthcare.Design/methodology/approachThe authors review published academic research and reports on practice across a range of disciplines.FindingsThe authors find that while value is a multidimensional concept, which is open to perceptions that differ across stakeholders in healthcare, financial economics-based accounting is essentially mono-disciplinary and dominates decisions. Enhancing value in health is a wicked problem, and a trans-disciplinary approach has the potential to enable decision-makers to enhance value.Practical implicationsThe suggest that a trans-disciplinary approach, which dissolves disciplinary boundaries, is capable of enabling decision-makers to work towards understanding and enhancing value by fostering awareness of stakeholders' perceptions of value. A critical caveat is that a trans-disciplinary approach does not guarantee ready-made or immediate solutions; it does, however, offer the means to struggle towards a destination which may be continually shifting.Originality/valueThis study highlights the importance of a broader understanding of the concept of value than that implied by financial economics-based accounting and recognises the perceptions of stakeholders. It explores the inter-relationship among “the view from nowhere”, wicked problems and trans-disciplinarity and recommends a trans-disciplinary approach with a view to enhancing value in that broader sense. In this way, it contributes to the accounting literature, which has previously paid little attention to some of these aspects.
Can intellectual capital promote the competitive advantage? Service innovation and big data analytics capabilities in a moderated mediation model
Authors: Alkhatib Ayman Wael , Valeri Marco 
Published: June 2022

PurposeThis study explores the connection between intellectual capital (IC) components and the competitive advantage (CA) of the hospitality sector in Jordan through the mediating role of service innovation as well as the moderating role of big data analytics capabilities.Design/methodology/approachData were collected through a self-administered questionnaire from the hospitality sector with a sample of 402 respondents. Data were analysed using SmartPLS, a bootstrapping technique was used to analyse the data. The mediating effect for service innovation and the moderating effect for big data analytics capabilities were performed.FindingsThe results showed that the proposed moderated-mediation model was accepted because the relationships between the constructs were statistically significant. The results of the data analysis supported a positive relationship between human capital, structural capital and relational capital and the CA as well as a mediating effect of service innovation. The findings confirmed that there is a moderating relationship for big data analytics capabilities between service innovation and CA. The results illustrate the importance of IC and service innovation in enhancing CA in the Jordanian hospitality sector in light of the big data analytics capabilities.Research limitations/implicationsThis cross-sectional study provides a snapshot at a given moment in time, a methodological limitation that affects the generalisation of the limitation's results, and the results are limited to one sector.Originality/valueThis research developed a theoretical model to incorporate IC components, service innovation, big data analytics capabilities and CA. This paper offers new theoretical and practical contributions that add value to the innovation and CA literature by testing the moderated-mediation model of these constructs in the hospitality sector which has been greatly affected by the coronavirus disease 2019 (COVID-19) pandemic. This study is distinguished from other studies by highlighting the role of IC and service innovation in enhancing CA as service innovation contributes to the formation of many organisational advantages in the Jordanian hospitality sector.
Foodstagramming as a self-presentational behavior: perspectives of tourists and residents
Authors: Lin Bingna , Fu Xiaoxiao , Lu Lu 
Published: June 2022

Purpose
This study aims to investigate diners’ self-presentation mechanism as manifested in foodstagramming. Drawing upon the social cognitive and self-presentation theories, this study develops a conceptual model to examine the relationships among food experiential value (i.e. extrinsic value and intrinsic value), self-efficacy, strategic self-presentation and self-presentation outcomes.

Design/methodology/approach
The authors adopt a multi-study approach with two empirical studies (Study 1: tourists, n = 254; Study 2: residents, n = 252) and use partial least squares structural equation modeling to test the proposed model.

Findings
The results consistently show significant effects of extrinsic value, intrinsic value and self-efficacy on strategic self-presentation, which subsequently evokes perceived enjoyment and behavioral intention. The impact of food experiential value on self-efficacy varies between tourists and residents. The mediating effects of self-efficacy and strategic self-presentation are also confirmed.

Practical implications
Restaurant managers and destination marketers should acknowledge the importance of food experience as expressive capital and recognize self-presentation as a meaningful tool that links restaurant food experience with consumers’ personal branding. Businesses should strive to create a desired experiential setting shaped by food price, restaurant service, food aesthetics and consumers’ feelings, allowing diners to translate these stimuli into self-presentational resources.

Originality/value
This study dives into an important, yet under-examined, phenomenon of foodstagramming. To the best of the authors’ knowledge, this study is the first to theoretically link food experience to foodstagramming behavior via a self-presentation mechanism. Findings provide important theoretical and managerial implications.
The power of institutions on international marketing: reflections on the COVID-19 pandemic can inform international marketing activities
Authors: Griffith David A. , Yalcinkaya Goksel 
Published: June 2022

PurposeThe COVID-19 pandemic highlights the influence that nation-states can have on the engagement of international marketing activities. The purpose of this study is to understand the influence of the institutional response to the COVID-19 pandemic on international marketing activities and to highlight the need to formally incorporate institutional economics into the study of international marketing phenomena.Design/methodology/approachThe paper uses institutional economics as the environmental element of the general theory of competitive rationality to present a foundation for understanding how state actions influence marketing and international marketing activities. Data are presented and empirically tested, demonstrating the heterogeneity of government influence on personal and economic freedoms during the pandemic, both of which influenced international marketing activities. To broaden the implications of this work, we also provide anecdotal illustrations unrelated to the COVID-19 pandemic to demonstrate the breadth of nation-state influence on international marketing activities.FindingsHeterogeneity in nation-state formal and informal institutional elements influence international marketing activities during the COVID-19 pandemic. However, other incidents, unrelated to the COVID-19 pandemic, demonstrate the importance of contextualizing international marketing activities under a holistic institutional framework.Originality/valueThe paper employs the general theory of competitive rationality along with institutional economics to provide a theoretical foundation to better understand the differential impact on international marketing as a result of formal and informal institutional influences. This general framework can be employed to provide a holistic understanding of both international and cross-national marketing activities.
Validating the antecedents of customer M-payment loyalty: an empirical investigation
Authors: Tripathi Shalini Nath , Malik Nishtha , Rana Nripendra P. , Vishnani Sushma , Srivastava Shalini 
Published: June 2022

PurposeThe study aims to explore antecedents and consequences of customer experience (CE) by positing a comprehensive framework taking cognizance of customer loyalty (CL), customer advocacy (CA), customer value dimensions, and subjective norms (SN).Design/methodology/approachThe study adopted a mixed-method sequential explanatory design where data were collected in two stages. In the initial stage (quantitative study), data were collected using a structured questionnaire from 395 respondents at two different periods and the data were analyzed using the partial least squares structural equation modeling (PLS-SEM) technique. These results were further verified in the second stage (qualitative study) by conducting semi-structured interviews of 37 respondents for which the data were analyzed using NVivo.FindingsThe results suggested a positive and significant relationship between utilitarian value (UV) and CA, hedonic value (HV) and CA as well as with CE. Further, the relationship between UV and CA is sequentially mediated by CE and CL; and the relationship between HV and CA is sequentially mediated by CE and CL. SN was also found to moderate the relationship between CE and CL. The qualitative analysis of the transcripts indicated major themes including HV (enjoyment), UV (usefulness and convenience), recommending mobile payment (M-payment) services, advocating for M-payment services and talking positively about the service provider.Originality/valueThe current study uses the mixed-method approach and comprehensively explores key dimensions of customer value associated with CE and CA, formalizes a relationship between all the facets, delivering valuable takeaways for academics and practitioners (for designing effective CE programs). The current study's uniqueness lies in the fact that the study is one of the first studies to explore the mediating roles of CE and CL using a serial-mediation approach, between UV, HV, SV, and CA. The moderating role of SN between CE and CL is also a novel contribution to the existing body of literature.
The role of leadership skills in the adoption of business intelligence and analytics by SMEs
Authors: Wee Mak , Scheepers Helana , Tian Xuemei 
Published: June 2022

PurposeA key finding in the extant literature on adopting information systems has been the importance of management support and a champion. Further research has indicated that business managers need to have appropriate IT knowledge and skills to lead adoption adequately. In the context of small and medium enterprises (SMEs), this role is usually assumed by the owner/manager. This research aims to synthesise these two tenets by identifying and understanding the type of business intelligence and analytics (BI&A) leadership skills that owners/managers need to develop during the adoption of BI&A.Design/methodology/approachFive BI&A knowledge areas are identified and connected to different types of BI&A leadership skills through qualitative in-depth case studies of fourteen Australian SMEs.FindingsThe case studies reveal that several BI&A leadership skills need to be developed to bring SMEs to higher stages of BI&A adoption.Practical implicationsThis study proposes a BI&A leadership skills development framework that allows practitioners to develop progressive BI&A skills concerning managing data, analytical skills, business processes, social and cultural change, and investment decisions to achieve sustainable operational, management and strategic goals.Originality/valueThe paper takes a unique approach that links five knowledge areas to BI&A leadership skills that owners/managers need to ensure for effective adoption and orchestration of BI&A in their organisations. The BI&A leadership framework includes a developmental approach that relates to the iterative and complex nature of BI&A adoption.