bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors
Authors: Malkova A. M. , Orlova R. V. , Zhukova N. V. , Gubal A. R. , Sharoiko V. V. 
Published: May 2022

The aim of the study. to analyse possible markers of an effective antitumor cellular immune response.Material and methods. using the keywords «checkpoint inhibitors, immunotherapy, t-lymphocytes, exhausted t-lymphocytes, anti-tumor immune response», review and original articles (n=34) published from 2005 to 2020 in the Pubmed, Web Of Science, Elsevier databases were selected.Results. the study revealed possible markers reflecting a high activity of an adaptive immune response based on effective recognition of tumor antigens through MHC molecules, a sufficient number of T-lymphocytes and a predominance of T-cytotoxic cells, as well as a low level of expression of inhibitory receptors and small molecules. the presence of single nucleotide polymorphisms in the HLA-I and HLA-II genes encoding MHC-I and MHC-II proteins, respectively, a high level of lymphocytes, among which the most important is the predominance of CD8+ t cells and a low level of T-regulatory cells (T-reg), as well as the presence of single nucleotide polymorphisms in the genes encoding FcγR receptors of T-lymphocytes showed their predictive significance. the diagnostic significance of determining the expression of inhibitory receptors for T-lymphocytes (TIM3, LAG3, TIGIT), especially in combination with the determination of PD-1 expression, was also revealed.Conclusion. the results obtained may be relevant for applying new methods for the assessment of the functional activity of the T-cell immune response before starting therapy with checkpoint inhibitors, as well as for the development of new diagnostic panels, which may be of interest to employees of clinical diagnostic laboratories and research centers.
Rare case of primary hepatoid adenocarcinoma of the lung
Authors: Toneev E. A. , Martynov A. A. , Lazarevsky M. M. , Pikin O. V. 
Published: May 2022

Hepatoid adenocarcinoma is a rare type of adenocarcinoma with hepatocellular differention, which is characterized by early metastatic spread and poor prognosis. The treatment strategy in not clearly defined due to an extreme rarity of the tumor. Surgery is the most effective tool as a part of multimodality concept. So far, only 51 cases have been described in the literature, and only one in Russia.Clinical case description.We report a case of metastatic hepatoid adenocarcinoma of the lung in a 54-year-old male patient. The difficulties in morphologic differential diagnosis between adenocarcinoma of the lung and primary liver cancer were described. The strategy for managing patients with hepatoid adenocarcinoma of the lung was demonstrated.Conclusion.Hepatoid adenocarcinoma of the lung is a rare tumor with unfavourable outcome.
Comparative analysis of tumor control gene and microRNA expression profiles in tumor and adjacent tissues in patients with colorectal cancer
Authors: Sluzhev M. I. , Zaraisky M. I. , Semiglazov V. V. , Semiglazova T. Yu. , Tkachenko E. V. , Kondratev S. V. , Brish N. A. , Alekseeva Yu. V. , Petrik Iu. V. , Sidorova A. N. 
Published: May 2022

Background. Various tumor control genes and microRNAs (miRNa) play an important role in the development and progression of colorectal cancer (CRC). the expression of these genes can differ significantly in tumor and adjacent healthy tissues. there is no exact data at what distance from the tumor the adjacent healthy tissue is located in terms of gene expression.The aim of the investigation was to study the tumor control genes (E2F3, TGFB, NFKB, KLF-12, EGFR and MMP9), as well as the microRNA genes (microRNA-15, -16, -21 and -210) expression profiles in tumor and adjacent healthy tissues.Material and methods. the study included 19 patients diagnosed with colorectal cancer. the tumor control genes (E2F3, TGFB, NFKB, KLF-12, EGFR and MMP9), as well as the miRNA genes (miRNA-15, -16, -21 and -210) expression levels were investigated in tumor and adjacent normal tissue samples taken during colonoscopy.Results. a decrease in the level of expression of E2F3 (median 3,73, Q1-Q3 2,64 Reu vs. median 6.5, Q1-Q3 6,39 REU, p=0,01) and miRNA-16 (median 2,83, Q1-Q3 4,74 REU vs. median 4,29, Q1-Q3 3,73 REU, p=0,027) and an increase in the expression level of miRNA-21 (median 2,64, Q1-Q3 1,38 REU vs. median 1,41, Q1-Q3 1,21 REU, p<0,001) were found in tumor tissue compared to normal tissue of patients with CRC.Conclusion. significant differences in the E2F3, miRNA-16 and miRNA-21 gene expressions were revealed. an increased level of E2F3 and miRNA-16 expressions at a distance of 1–2 cm from the tumor may be a predictor of tumor recurrence and progression, and an increased miRNA-21 expression in tumor tissue as compared to adjacent tissue may be a negative prognostic factor. this information can be used in further clinical research.
Safety and benefits of early oral nutrition as part of the fast-track program among patients who have undergone gastrectomy for stomach cancer
Authors: Pavlov R. V. , Timofeeva K. O. , Chernykh M. A. , Danilin V. N. 
Published: May 2022

Over the past decade, stomach cancer continues to be one of the most common diseases in the world. Currently, the methods of conservative and surgical treatment of this disease are fairly standardized. However, the issue of postoperative management of patients, including the timing of the start of oral nutrition after surgery still remains debatable. In addition, modern methods of treatment are based on the use of protocols for enhanced recovery after surgery, the safety of which remains controversial and requires discussion.Study object was to explore the safety and benefits of early oral nutrition among patients who have undergone gastrectomy for stomach cancer.Material and methods. The authors present their own experience of nutritional support for patients who underwent gastrectomy. The study included 82 patients with locally advanced stomach cancer who received surgical treatment at the n.i. Pirogov clinic of high medical technologies in the period from 2016 to 2019.Results. The safety and positive effect of the use of early oral feeding was proved. It was associated with shorter first exhaust time (2.8 ± 1.0 days vs 3.9 ± 1.2 days, p=0.001), shorter postoperative length of stay in the hospital (5.4 ± 1.5 days vs 9.5 ± 2.3 days; p=0.001), as well as a more dynamic recovery of laboratory parameters.Conclusion. Early per oral nutrition after gastrectomy can reduce the length of hospital stay without increasing the incidence of concomitant complications, which indicates its safety, expediency and potential benefit for patients with gastric cancer.
Acidentes de trabalho em uma maternidade pública de referência
Authors: Costa Maria Carolina Da Silva , Gouveia Márcia Teles de Oliveira , Nunes Açucena Barbosa , Moraes Hylda Mara Cruz de , Fernandes Márcia Astrês , Costa Jéssica Pereira 
Published: May 2022

Objetivo: Analisar os acidentes de trabalho ocorridos em uma maternidade pública de referência para o nordeste brasileiro. Método: Estudo transversal realizado com dados de registros de 102 profissionais acidentados em uma maternidade pública de referência. Realizou-se análise estatística descritiva e aplicou-se o teste exato de Fisher. Resultados: O estudo apontou maior prevalência anual de acidentes de trabalho no ano de 2017 (2,44%), com predominância do sexo feminino (75,5%) e trabalhadores com 1 a 5 anos de tempo de serviço (32%). A categoria profissional mais acometida foi a de Técnico (a) de Enfermagem (38,6%); sendo mãos/dedos como as partes do corpo mais afetadas (53,6%) e os perfuro cortantes como os agentes causadores mais mencionados (48,5%). Conclusão: Evidenciou-se a necessidade de maior investimento nas ações de educação permanente em relação à notificação e às medidas preventivas com vistas à diminuição da ocorrência dos agravos relacionados ao trabalho.
Netnografia e a pesquisa em Enfermagem em ambiente virtual: experiência com adolescentes no Facebook
Authors: Aragão Joyce Mazza Nunes , Gubert Fabiane Do Amaral , Vieira Neiva Francenely Cunha 
Published: May 2022

Objetivo: relatar o uso da netnografia para pesquisa em enfermagem no Facebook com adolescentes escolares. Método: estudo qualitativo, netnográfico de observação participante, realizado em dois grupos da rede social Facebook, criados para a prática educativa em saúde de enfermagem junto a adolescentes. Resultados: O uso da netnografia possibilitou evidenciar a cibercultura no contexto da adolescência e como esta intervém no processo de ensino-aprendizagem online. As relações de ensino-aprendizagem em saúde mediadas pelo Facebook, consolidaram-se em rede de colaboração entre enfermeira e adolescentes. Considerações finais: A netnografia é uma técnica com potencial na pesquisa, especialmente na atualidade, todavia, é pouco referida na área da saúde e Enfermagem. O estudo procurou contornar esse desafio do conhecimento, apresentando a abordagem da netnografia para pesquisa online com junto a adolescentes no Facebook, ampliando assim, essas possibilidades.
Percepções de pessoas com sequelas pela hanseníase acerca do autocuidado
Authors: Costa Rayla Maria Pontes Guimarães , Mendes Layza Castelo Branco , Santos Gerarlene Ponte Guimarães , Almeida Joelson dos Santos 
Published: May 2022

Objetivo: o estudo teve como objetivo conhecer as percepções de pessoas com sequelas pela hanseníase acerca das ações de autocuidado, à luz do seu contexto cultural. Método: estudo descritivo, exploratório com abordagem qualitativa, realizado com 12 pessoas com sequelas pela hanseníase, atendidas em um hospital colônia no estado do Piauí. Foram utilizadas entrevistas semiestruturadas, que posteriormente foram submetidas à técnica do Discurso do Sujeito Coletivo, tendo como suporte neste processo o software Iramuteq versão 0.7. Resultados: evidenciou-se que as percepções das pessoas relacionadas ao autocuidado estão ligadas às práticas de higiene corporal e oral, necessitando de apoio ao autocuidado por meio da compreensão do seu universo cultural. Considerações Finais: o autocuidado abrange uma dimensão integral de cuidados que deve ser inserido no contexto cultural das pessoas, que realizado de forma eficiente, proporciona melhorias no bem-estar e na qualidade de vida.
Prevalência de sepse em um centro de terapia intensiva de um hospital de ensino
Authors: Rodrigues de Carvalho Mayara Kelle , Rocha Duarte de Carvalho Marianne 
Published: May 2022

Objetivo: Avaliar a prevalência de sepse, em um Centro de Terapia Intensiva, de um hospital de ensino. Metodologia: Estudo descritivo, exploratório, retrospectivo, com abordagem quantitativa, realizado em Centro de Terapia Intensiva de um hospital de referência em Teresina-PI, Brasil, cujos dados foram coletados em 221 prontuários de pacientes internados nesse setor, no ano de 2018. A análise dos dados foi realizada com o Stastistical Package for the Social Sciennces, por meio de estatística descritiva e inferencial. Resultados: A prevalência de sepse no Centro de Terapia Intensiva investigado foi de 20,36% (n=45). A média de permanência neste foi de 10,73 dias (DP ± 15,53) e a maioria evoluiu para óbito 62,2% (n=28). Conclusões: A prevalência de sepse no presente estudo foi baixa, se comparada ao índice mundial que é mais elevado. Trata-se de problema de saúde pública, de alto custo para os serviços e que acarreta mortalidade. Descritores: Sepse; Prevalência; Unidades de Terapia Intensiva.
Virtual Reality Applications in Chronic Pain Management: Systematic Review and Meta-analysis
Authors: Goudman Lisa , Jansen Julie , Billot Maxime , Vets Nieke , De Smedt Ann , Roulaud Manuel , Rigoard Philippe , Moens Maarten 
Published: May 2022

BackgroundVirtual reality (VR) is a computer technology that immerses a user in a completely different reality. The application of VR in acute pain settings is well established. However, in chronic pain, the applications and outcome parameters influenced by VR are less clear.ObjectiveThis review aimed to systematically identify all outcome parameters that are reported in relation to VR in patients with chronic pain.MethodsA total of 4 electronic databases (PubMed, Scopus, Web of Science, and Embase) were searched for relevant studies. Multilevel random-effect meta-analyses were performed, whereby the standardized mean difference was chosen as the effect size to denote the difference between measurements before and after a VR intervention.ResultsThe initial database search identified 1430 studies, of which 41 (2.87%) were eventually included in the systematic review. Evidence has been found for the effects of VR on pain, functioning, mobility, functional capacity, psychological outcomes, quality of life, neuropsychological outcomes, and physical sensations. The overall effect size (a total of 194 effect sizes from 25 studies) based on a three level meta-analysis was estimated at 1.22 (95% CI 0.55-1.89; z=3.56; P<.001), in favor of improvements after a VR intervention. When categorizing effect sizes, the overall effect sizes were reported as follows: 1.60 (95% CI 0.83-2.36; z=4.09; P<.001) for the effect of VR on pain (n=31), 1.40 (95% CI 0.13-2.67; z=2.17; P=.03) for functioning (n=60), 0.49 (95% CI −0.71 to 1.68; z=0.80; P=.42) for mobility (n=24), and 0.34 (95% CI −1.52 to 2.20; z=0.36; P=.72) for functional capacity (n=21).ConclusionsThis systematic review revealed a broad range of outcome variables influenced by an intervention of VR technology, with statistically significant pain relief and improvements in functioning. These findings indicate that VR not only has applications in acute pain management but also in chronic pain settings, whereby VR might be able to become a promising first-line intervention as complementary therapy for patients with chronic pain.Trial RegistrationPROSPERO International Prospective Register of Systematic Reviews CRD42021227016; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=227016
REDES DE SERVIÇOS HOSPITALARES: GOVERNANÇA COMO PRÁTICA DE CONTROLE E REGULAÇÃO DOS PROCESSOS BUROCRÁTICOS
Authors: Fernandez Veloso Cristiane , Bazanini Roberto , Machado Júnior Celso , Adra Ricardo Daniel 
Published: May 2022

Objetivo: Este artigo tem como objetivo analisar o perfil da governança no setor hospitalar.
Método / abordagem: A abordagem da pesquisa se caracteriza por utilizar o método dedutivo, de natureza aplicada e caráter exploratório de abordagem qualitativa, apoiada em um estudo multicasos em redes de serviços hospitalares. A coleta de dados envolveu três diferentes técnicas: entrevista semiestruturada com gestores das instituições, aplicação de questionário junto aos funcionários e análise de documentação interna das instituições.
Principais resultados: Os principais resultados da pesquisa indicam que as categorias que se referem aos procedimentos de controles do comportamento e do processo são os mais valorizados em detrimento dos aspectos que se voltam para os relacionamentos sociais como fatores estratégicos promotores da confiança e/ou comprometimento.
Contribuições do estudo: A pesquisa apresenta como contribuição gerencial e teórica o entendimento de que governança da área da saúde está direcionada a práticas de controle e exercício de poder e regulação de processos burocráticos.
Originalidade / relevância: A relevância da pesquisa se estabelece pelo esclarecimento de uma lacuna no entendimento da governança na área da saúde hospitalar, que conforme os dados desta pesquisa, apresenta diferenças em relação aos outros setores da economia.
EFEITO DO EVENTO CLIMÁTICO ADVERSO DA ESTIAGEM NAS CARACTERÍSTICAS COERCITIVAS E HABILITANTES DO ORÇAMENTO
Authors: De Jesus Silva Thiago Bruno , Facin Lavarda Carlos Eduardo , Mendes de Oliveira Renata 
Published: May 2022

Objetivo: Este estudo buscou compreender o efeito do evento climático adverso da estiagem na utilidade do orçamento agrupada no planejamento e diálogo de uma organização do agronegócio brasileiro.
Método / abordagem: A pesquisa classifica-se como estudo de caso único, sendo realizada em uma organização que atua no segmento do agronegócio. A coleta de dados foi realizada por meio de roteiro de entrevista aplicado ao gestor e observação de documentos disponibilizados pela organização. A análise dos dados compreendeu a triangulação, com análise do texto da entrevista, bem como a observação dos registros internos e documentos. O Nvivo 10 auxiliou na operacionalização ao gerar relatório, por categoria codificada, com trechos da entrevista e do material observado.
Principais resultados: Constatou-se em momentos de estiagem, a alta administração emite regras com o intuito de conduzir, de forma obrigatória, o seu cumprimento. Embora não se tenha observado presença de diálogo para tomada de decisões e o não estímulo a interação entre as distintas hierarquias, foi perceptível o aprendizado organizacional contínuo e que dissemina conhecimento para alcançar os objetivos.
Contribuições metodológicas / sociais / gerenciais: Os achados da pesquisa contribuem com o fluxo de estudos que visam explicar a importância dos controles no âmbito organizacional. Contribui ainda para a prática da gestão, destacando a necessidade de ampliação da utilidade do orçamento no que concerne ao uso orgânico.
Originalidade / relevância: Destaca-se a relevância da pesquisa ao considerar o contexto do agronegócio, campo ainda pouco explorado, principalmente, no que tange à abordagem das práticas de gestão.
Defisit Anggaran dan Implikasinya terhadap Perkembangan Ekonomi dan Kinerja Keuangan Kabupaten Tebo
Authors: Prihatiningsih Astuti , Rachmad R M. , HM Syamsuddin 
Published: May 2022

This study aims to 1) To analyze the determinants that will influence the budget deficit in Tebo district budget. 2) To analyze whether there is a correlation between the budget deficit with Tebo regency economic development. 3) To analyze whether there is a correlation between the financial performance of the budget deficit with Tebo regency. The method used in this study is a secondary data analysis methods. Based on the results of testing the model regression shows the value of the F-count is high at 12 130. With an alpha of 0.05 df1 = 3, DF2 = 4 obtained F-table at 6:59. so the F-count> F-table. this indicates that the independent variables are jointly significant effect on the dependent variable, so that personnel expenditure, capital expenditure and spending on goods and services during the period 2004-2011 are jointly significant effect on the budget deficit in Tebo regency. Each there is an increase of 1 billion budget deficit, it will cause a reduction in personnel expenses amounted to 4.52 billion Tebo regency. Any increased capital expenditure budget of 1 billion budget deficit will increase by 5.01 billion. Any increased budget allocation of goods and services amounted to 1 billion, the budget deficit will increase by 8.17 billion. the greatest influence on the budget deficit from the budget allocation of goods and services. The results of the analysis of the budget deficit relationship with economic development in Tebo regency during 2006-2010 showed that the budget deficit by using a simple Pearson correlation test has a relationship of -0.07986. These results illustrate that the budget deficit has a negative relationship with economic development. The results of the analysis of the relationship with the budget deficit in the region's financial performance during the period 2006-2010 Tebo regency showed that the budget deficit with the financial performance using tools Pearson correlation test has a relationship of -0.04703. The results illustrate that the budget deficit has a negative relationship with financial performance. Keywords: budget deficit, budget allocation, capital expenditure budget
Analisis Pendapatan Usaha Pengrajin Gula Aren Di Desa Tulo’a Kecamatan Bulango Utara Kabupaten Bone Bolango
Authors: Saleh Yanti 
Published: May 2022

Penelitian ini bertujuan untuk menganalisis besarnya pendapatan pengrajin gula aren di Desa Tulo’a dan untuk menganalisis besarnya keuntungan pengrajin gula aren di Desa Tulo’a. Penelitian ini dilaksanakan pada bulan mei sampai bulan juli 2013. Metode yang digunakan dalam penelitian ini adalah metode survey yang terdiri dari data primer yang diperoleh melalui wawancara dengan pengrajin gula aren dengan menggunakan kuisioner/daftar pertanyaan dan data sekunder diperoleh dari Kantor Desa Tulo’a serta Dinas Perindustrian dan Perdagangan Kabupaten Bone Bolango. Teknik pengambilan sampel dilakukan dengan menggunakan metode sampling jenuh atau sensus dimana semua anggota populasi responden dijadikan sampel. Analisis data yang digunakan yaitu biaya tetap, biaya variabel, total biaya, penerimaan, pendapatan, dan analisis R/C Ratio. Hasil penelitian menunjukkan bahwa rata-rata pendapatan bersih/keuntungan yang diperoleh pengrajin gula aren di Desa Tulo’a yaitu sebesar Rp. 1.395.684/bulan atau Rp. 16.748.208/tahun. Dengan nilai R/C Ratio sebesar 2,12. Berdasarkan kriteria nilai R/C Ratio lebih dari satu berarti dapat dikatakan usaha pengrajin gula aren di Desa Tulo’a menguntungkan dan layak untuk diusahakan. Keywords: Pengrajin, Gula Aren, Pendapatan, Keuntungan
Analisis Produksi dan Pendapatan Petani Karet di Kabupaten Bungo
Authors: Ali Jonni , Delis Arman , Hodijah Siti 
Published: May 2022

The purpose of this study was to identify the characteristics of rubber farmers, to determine and analyze revenue and profit rubber production in the sample, to determine and analyze the level of income inequality rubber farmers of the people in the sample, and to identify and analyze the factors that affect smallholder rubber production in the sample. Based on these results suggested to the government should work closely with farmers in encouraging the opening of degraded land through various cooperation for optimal land use, because the land proved to have a significant influence on people's rubber production in Bungo.
Analisis Keterkaitan Industri Pengolahan dalam Perekonomian Provinsi Jambi (Pendekatan Input Output)
Authors: Firmansyah Muhammad , Haryadi Haryadi , Umiyati Etik 
Published: May 2022

Abstract. Analysis of the manufacturing sector in the province of Jambi found that: 1) The manufacturing sector which has the greatest value of direct forward linkage is the fertilizer industry sector, while the manufacturing sector which has the gratest value of direct and indirect forward linkage is the CPO industry sector ; 2) The manufacturing sector that has the largest value of backward linkage is fertilizer industry sector, while the manufacturing sector which has has the greatest value of direct and indirect backward linkage is CPO industry sector; 3) The results of the simulation injection indirect spending generates economic growth is small, while simulating the injection of direct expenditure economic growth is relatively large compared to injection of indirect expenditures. Keyword : Input Output , forward linkage, backward linkage Abstrak. Hasil analisis terhadap sektor industri pengolahan di Provinsi Jambi menemukan bahwa: 1) Industri pengolahan yang memiliki nilai keterkaitan langsung ke depan terbesar adalah industri pupuk, sedangkan yang memiliki nilai keterkaitan langsung dan tidak langsung kedepan terbesar adalah sektor industri CPO; 2) Industri pengolahan yang memiliki nilai keterkaitan ke belakang terbesar adalah industri pupuk, sedangkan yang memiliki nilai keterkaitan langsung dan tidak langsung kebelakang terbesar adalah industri CPO; 3) Hasil simulasi injeksi belanja tidak langsung secara keseluruhan menghasilkan pertumbuhan ekonomi yang kecil, sedangkan simulasi injeksi belanja langsung secara keseluruhan mampu menghasilkan pertumbuhan ekonomi yang relatif besar dibandingkan injeksi belanja tidak langsung. Kata Kunci :Input Output, Keterkaitan Kedepan, Keterkaitan Kebelakang