bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turning the lens in the study of precarity: On experimental social psychology's acquiescence to the settler‐colonial status quo in historic Palestine
Authors: Hakim Nader , Abi‐Ghannam Ghina , Saab Rim , Albzour Mai , Zebian Yara , Adams Glenn 
Published: November 2022

AbstractThis review examines the coloniality infused within the conduct and third reporting of experimental research in what is commonly referred to as the ‘Israeli‐Palestinian conflict’. Informed by a settler colonial framework and decolonial theory, our review measured the appearance of sociopolitical terms and critically analysed the reconciliation measures. We found that papers were three times more likely to describe the context through the framework of intractable conflict compared to occupation. Power asymmetry was often acknowledged and then flattened via, for instance, adjacent mentions of Israeli and Palestinian physical violence. Two‐thirds of the dependent variables were not related to material claims (e.g. land, settlements, or Palestinian refugees) but rather to the feelings and attitudes of Jewish Israelis and Palestinians. Of the dependent measures that did consider material issues, they nearly universally privileged conditions of the two‐state solution and compromises on refugees' right of return that would violate international law. The majority of the studies sampled Jewish–Israeli participants exclusively, and the majority of authors were affiliated with Israeli institutions. We argue that for social psychology to offer insights that coincide with the decolonization of historic Palestine, the discipline will have to begin by contextualizing its research within the material conditions and history that socially stratify the groups.
Anomalies in neurovascular coupling during early diabetes: A review
Authors: Fletcher Erica L. , Dixon Michael A. , Mills Samuel A. , Jobling Andrew I. 
Published: November 2022

AbstractDiabetic retinopathy is the most feared complication for those with diabetes. Although visible vascular pathology traditionally defines the management of this condition, it is now recognised that a range of cellular changes occur in the retina from an early stage of diabetes. One of the most significant functional changes that occurs in those with diabetes is a loss of vasoregulation in response to changes in neural activity. There are several retinal cell types that are critical for mediating so‐called neurovascular coupling, including Müller cells, microglia and pericytes. Although there is a great deal of evidence that suggests that Müller cells are integral to regulating the vasculature, they only modulate part of the vascular tree, highlighting the complexity of vasoregulation within the retina. Recent studies suggest that retinal immune cells, microglia, play an important role in mediating vasoconstriction. Importantly, retinal microglia contact both the vasculature and neural synapses and induce vasoconstriction in response to neurally expressed chemokines such as fractalkine. This microglial‐dependent regulation occurs via the vasomediator angiotensinogen. Diabetes alters the way microglia regulate the retinal vasculature, by increasing angiotensinogen expression, causing capillary vasoconstriction and contributing to a loss of vascular reactivity to physiological signals. This article summarises recent studies showing changes in vascular regulation during diabetes, the potential mechanisms by which this occurs and the significance of these early changes to the progression of diabetic retinopathy.
Effects of different management strategies on long‐term trends of Australian threatened and near‐threatened mammals
Authors: Tulloch Ayesha I. T. , Jackson Micha V. , Bayraktarov Elisa , Carey Alexander R. , Correa‐Gomez Diego F. , Driessen Michael , Gynther Ian C. , Hardie Mel , Moseby Katherine , Joseph Liana , Preece Harriet , Suarez‐Castro Andrés Felipe , Stuart Stephanie , Woinarski John C. Z. , Possingham Hugh P. 
Published: November 2022

AbstractMonitoring is critical to assess management effectiveness, but broadscale systematic assessments of monitoring to evaluate and improve recovery efforts are lacking. We compiled 1808 time series from 71 threatened and near‐threatened terrestrial and volant mammal species and subspecies in Australia (48% of all threatened mammal taxa) to compare relative trends of populations subject to different management strategies. We adapted the Living Planet Index to develop the Threatened Species Index for Australian Mammals and track aggregate trends for all sampled threatened mammal populations and for small (<35 g), medium (35–5500 g), and large mammals (>5500 g) from 2000 to 2017. Unmanaged populations (42 taxa) declined by 63% on average; unmanaged small mammals exhibited the greatest declines (96%). Populations of 17 taxa in havens (islands and fenced areas that excluded or eliminated introduced red foxes [Vulpes vulpes] and domestic cats [Felis catus]) increased by 680%. Outside havens, populations undergoing sustained predator baiting initially declined by 75% but subsequently increased to 47% of their abundance in 2000. At sites where predators were not excluded or baited but other actions (e.g., fire management, introduced herbivore control) occurred, populations of small and medium mammals declined faster, but large mammals declined more slowly, than unmanaged populations. Only 13% of taxa had data for both unmanaged and managed populations; index comparisons for this subset showed that taxa with populations increasing inside havens declined outside havens but taxa with populations subject to predator baiting outside havens declined more slowly than populations with no management and then increased, whereas unmanaged populations continued to decline. More comprehensive and improved monitoring (particularly encompassing poorly represented management actions and taxonomic groups like bats and small mammals) is required to understand whether and where management has worked. Improved implementation of management for threats other than predation is critical to recover Australia's threatened mammals.
Antecedents of top management team and board gender diversity: A review and an agenda for research
Authors: Yao Ting 
Published: November 2022

AbstractResearch Question/IssueThe paper aims to understand the factors hindering and facilitating women's access to top management teams (TMTs) and boards of directors. It provides a systematic review of extant scholarly work on the antecedents of TMT and board gender diversity.Research Findings/InsightsReviewing and integrating research from over 200 journal publications, I develop an integrative review of the antecedents of gender diversity for two types of research contexts—TMT and board—at three levels: person centered, situation centered, and social‐system centered. I also identify knowledge gaps and suggest areas for future research.Theoretical/Academic ImplicationsThis comprehensive review of extant research simultaneously considers antecedents of TMT gender diversity and board gender diversity, providing insights into divergent trends of TMT and board gender diversity while highlighting understudied areas. Hopefully, the review will inspire more research to advance knowledge of the antecedents of TMT and board gender diversity, areas that have received relatively little attention compared with extensive research on the consequences of gender diversity.Practitioner/Policy ImplicationsGender diversity in corporate leadership is a topic of great interest. The growth in board gender diversity is unprecedented, but growth in TMT gender diversity has been stagnant. I offer a synthesis of extant literature to understand the social, situational, and individual drivers of TMT and board gender diversity, providing valuable insights for policymakers, investors, executives, and directors who seek to improve corporate leadership gender diversity.
Pediatric CYP2D6 metabolizer status and post‐tonsillectomy nausea and vomiting after ondansetron
Authors: Black Katherine , Brenn B. Randall , Gaedigk Andrea , Wanderer Jonathan P. , Van Driest Sara L. 
Published: November 2022

AbstractThe goal of this study was to determine whether CYP2D6 metabolizer status within the ondansetron‐treated pediatric tonsillectomy population is associated with risk of postoperative nausea and vomiting (PONV) in the post‐anesthesia care unit. We conducted a retrospective cohort study of pediatric patients (<18 years) who underwent tonsillectomy and received ondansetron on the day of the procedure. Data were obtained from BioVU, an institutional biobank that links DNA to de‐identified electronic health record data. Subjects were tested for 10 CYP2D6 allelic variants and copy number variation, and genotype data translated into CYP2D6 metabolizer status. The cohort included 652 individuals, 105 (16.1%) of whom had PONV. Rates of PONV were similar across groups: ultrarapid metabolizers (UMs), 1 of 9 (11.1%); normal metabolizers (NMs), 64 of 354 (18.1%); intermediate metabolizers (IMs), 33 of 234 (14.1%); poor metabolizers (PMs), 6 of 39 (15.4%); and ambiguous phenotypes, 1 of 16 (6.3%). In multivariable analysis adjusted for age, sex, and time under anesthesia, CYP2D6 metabolizer status was not associated with PONV, with an odds ratio of 1.37 (95% confidence interval 0.9, 2.1) when comparing PM/IM versus NM/UM. In this large pediatric population, no significant differences were detected for PONV based on CYP2D6 metabolizer status. Further investigation is needed to determine mechanisms for ondansetron inefficacy in children.
Chordoma metastatic to skin: A report of two cases and a brief review of the literature
Authors: Dimopoulos Yiannis P. , Ivan Doina , Prieto Victor G. , Aung Phyu P. 
Published: November 2022

AbstractChordomas are rare, locally aggressive tumors of notochordal origin usually arising in the spine or base of the skull. Skin involvement is rare and typically occurs via direct extension of the primary tumor to the skin. Although there are increasing reports of the skin being involved as a distant metastatic site in patients with chordoma, this remains an exceedingly rare occurrence. We present two cases of patients diagnosed with metastasis of chordoma to the skin that represented distant metastasis. In the first case, a patient with a primary thoracic/lumbar chordoma presented with isolated metastasis to the skin of the left lower jaw 9 years after initial diagnosis of the chordoma. To our knowledge, this is the first reported case of a chordoma of this site to develop distant skin metastasis. In the second case, a patient with a primary sacral chordoma presented with metastasis to the skin of the right side of his chin 6 years after initial diagnosis of the chordoma, following previous metastatic spread to the liver and lung. Finally, we briefly review the literature on chordoma metastasis to the skin and highlight salient features to raise awareness of this uncommon occurrence.
The relationship between pesi score and pulmonary venous flow parameters in patients with acute pulmonary embolism
Authors: Aydınyılmaz Faruk , Özbeyaz Nail Burak , Algül Engin , Aksakal Alperen , Guliyev İlkin , Şahan Haluk Furkan , Aksakal Emrah , Saraç İbrahim , Kalkan Kamuran 
Published: November 2022

AbstractBackgroundAcute pulmonary embolism (APE) is an important cause of cardiovascular morbidity and mortality. PESI scoring is used in risk classification. This study was designed to determine the relationship between echocardiographic pulmonary vein measurements and PESI score, which is an important tool in diagnosis and treatment.MethodsA total of 210 patients were evaluated. Pulmonary vein measurements and PESI scores of the patients at the time of diagnosis were calculated. Correlation analysis was performed to determine the relationship between the two parameters.ResultsTotal PESI scores were 112.9 ± 33.9. The pulmonary vein S wave .39 ± .14, the D wave .48 ± .18, and the S/D ratio was found to be .86 ± .35. It was determined that there was a significant correlation between pulmonary S/D ratio and PESI score. (Pearson correlation coefficient = −.693, R2 Linear:.484; p < .001) The AUC of S/D for mortality prediction was .729 (95% CI = .653–.804; p < .001), the cutoff value was .63, the sensitivity and specificity were 55.6% and 55.7%, respectively.ConclusionPulmonary vein measurements were found to be correlated with the PESI score and were found to be a parameter that could predict mortality.
Mortality and basal area growth following precommercial thinning in stands affected by Armillaria, Laminated and Tomentosus root diseases in southern British Columbia
Authors: Morrison Duncan J. , Rönnberg Jonas , Pellow Kevin , Cleary Michelle 
Published: November 2022

AbstractPrecommercial thinning aims to reduce the density of immature stands to stimulate growth of well‐spaced crop trees of preferred species and free from defects and disease. The chronic persistence of Armillaria, Laminated and Tomentosus root diseases in coniferous forests of British Columbia, Canada may offset potential gains in timber yield of commercially important tree species by creating stumps that the fungi utilize as an energy source to infect neighbouring trees. In juvenile plantations and naturally regenerated stands in six biogeoclimatic (BEC) zones with evidence of root disease caused by Armillaria ostoyae (8 sites), Coniferiporia sulphurascens (2 sites) or Onnia tomentosa (1 site), five of ten 20 m square plots per site were randomly selected for thinning to British Columbia Ministry of Forests specifications. Crop tree diameter at breast height and mortality from all causes were recorded at establishment and periodically thereafter up to 19 years post‐thinning. Logistic regression analysis of mortality rates showed significant differences among root disease pathogens, between planted and natural stands, and among ecological zones. Yet over all sites, differences between thinned and control plots were not significant. At the final assessment, crop tree basal area was higher in thinned than in control plots at 10 of 11 sites. Root disease, including infected and dead trees and other lethal biotic and abiotic agents, reduced potential yield in both treatments (thinned and control). At several Armillaria sites, mortality was slightly to substantially higher in thinned than in control plots, suggesting that thinning can increase the amount and potential of inoculum which may continue to adversely impact productivity of those stands. Recommendations for silvicultural management of the three root diseases are discussed.
Successful removal of a functional parathyroid adenoma using a radio‐guided parathyroidectomy technique with a hand‐held gamma detector and technetium Tc 99m sestamibi scintigraphy in a horse
Authors: Connard Shannon S. , Hodge Elizabeth A. , Demchur Jolie A. , Wulster Kathryn B. , Johnson Amy L. , Ross Michael W. , Levine David G. 
Published: November 2022

SummaryThis clinical case report details the use of a radio‐guided parathyroidectomy technique using a hand‐held gamma detector and technetium Tc 99m sestamibi scintigraphy for detection and removal of a functional parathyroid adenoma in a horse. An 18‐year‐old Arabian gelding was diagnosed with primary hyperparathyroidism based on persistent hypercalcaemia and increased parathyroid hormone concentration. Single gland disease was suspected after technetium Tc 99m sestamibi scintigraphy showed focal increased radiopharmaceutical uptake (IRU) at the thoracic inlet. Ultrasonography failed to identify a discrete mass in the region of IRU. Surgical excision was recommended; however, due to unreliable preoperative localisation, a radio‐guided parathyroidectomy technique was elected. A radio‐guided parathyroidectomy technique was performed under general anaesthesia using a hand‐held gamma detector and technetium Tc 99m sestamibi scintigraphy to identify the parathyroid adenoma, which was subsequently excised. The horse recovered from the procedure without complication. Successful removal of the parathyroid adenoma was confirmed based on histopathological and serum bioch findings. Following the procedure, the horse showed no evidence of hyperparathyroidism and returned to light pleasure riding. Three years postoperatively, the gelding died of unrelated natural causes; a post‐mortem examination was not performed. This radio‐guided parathyroidectomy technique was effective in facilitating the removal of a parathyroid adenoma in this gelding and might be useful in other equids that have primary hyperparathyroidism IRU on technetium Tc 99m sestamibi scintigraphy, particularly if a discrete mass cannot be identified ultrasonographically.
Clinicopathological features of rhabdomyosarcoma with novel FET::TFCP2 and TIMP3::ALK fusion: report of two cases and literature review
Authors: Duan Fang‐Lei , Yang Hong , Gong Xiaojin , Zuo Zuo , Qin Sheng , Ji Juan , Zhou Chengmin , Dai Jie , Guo Peng , Liu Yang 
Published: November 2022

AimsThe aim of this study was to evaluate the clinicopathological features, immunophenotype, differential diagnosis, molecular genetic features and prognosis of spindle cell rhabdomyosarcoma with TFCP2 rearrangement.MethodsTwo cases of spindle cell rhabdomyosarcoma with FET::TFCP2 gene fusion were included in this study. Samples were collected and evaluated through histological observation, immunohistochemistry, fluorescence in‐situ hybridisation and high‐throughput gene sequencing and previous findings.ResultsThe tumour tissues mainly comprised spindle cells and epithelioid cells, which expressed striated muscle markers, and exhibited high expression levels of CK and ALK protein markers. Molecular detection showed that the FET::TFCP2 gene was fused. A rare case with TIMP3::ALK and FUS::TFCP2 double‐fusion was observed in this study.ConclusionsA case with double fusion of ALK and TFCP2 was reported in rhabdomyosarcoma for the first time in this study, which provides information on the molecular characteristic of the tumour. Spindle cell rhabdomyosarcoma with FET::TFCP2 fusion is characterised by histological, immunohistochemical and genetic changes. The tumour is aggressive, with poor prognosis and poor response to radiotherapy and chemotherapy. The efficacy of targeted therapy for ALK should be explored through more clinical studies.
Improving mitotic cell counting accuracy and efficiency using phosphohistone‐H3 (PHH3) antibody counterstained with haematoxylin and eosin as part of breast cancer grading
Authors: Ibrahim Asmaa , Toss Michael S. , Makhlouf Shorouk , Miligy Islam M. , Minhas Fayyaz , Rakha Emad A. 
Published: November 2022

BackgroundMitotic count in breast cancer is an important prognostic marker. Unfortunately, substantial inter‐ and intraobserver variation exists when pathologists manually count mitotic figures. To alleviate this problem, we developed a new technique incorporating both haematoxylin and eosin (H&E) and phosphorylated histone H3 (PHH3), a marker highly specific to mitotic figures, and compared it to visual scoring of mitotic figures using H&E only.MethodsTwo full‐face sections from 97 cases were cut, one stained with H&E only, and the other was stained with PHH3 and counterstained with H&E (PHH3–H&E). Counting mitoses using PHH3–H&E was compared to traditional mitoses scoring using H&E in terms of reproducibility, scoring time, and the ability to detect mitosis hotspots. We assessed the agreement between manual and image analysis‐assisted scoring of mitotic figures using H&E and PHH3–H&E‐stained cells. The diagnostic performance of PHH3 in detecting mitotic figures in terms of sensitivity and specificity was measured. Finally, PHH3 replaced the mitosis score in a multivariate analysis to assess its significance.ResultsPathologists detected significantly higher mitotic figures using the PHH3–H&E (median ± SD, 20 ± 33) compared with H&E alone (median ± SD, 16 ± 25), P < 0.001. The concordance between pathologists in identifying mitotic figures was highest when using the dual PHH3–H&E technique; in addition, it highlighted mitotic figures at low power, allowing better agreement on choosing the hotspot area (k = 0.842) in comparison with standard H&E (k = 0.625). A better agreement between image analysis‐assisted software and the human eye was observed for PHH3‐stained mitotic figures. When the mitosis score was replaced with PHH3 in a Cox regression model with other grade components, PHH3 was an independent predictor of survival (hazard ratio [HR] 5.66, 95% confidence interval [CI] 1.92–16.69; P = 0.002), and even showed a more significant association with breast cancer‐specific survival (BCSS) than mitosis (HR 3.63, 95% CI 1.49–8.86; P = 0.005) and Ki67 (P = 0.27).ConclusionUsing PHH3–H&E‐stained slides can reliably be used in routine scoring of mitotic figures and integrating both techniques will compensate for each other's limitations and improve diagnostic accuracy, quality, and precision.
Gender differences in suicidal ideation, suicide attempts, and suicide death among people living with HIV: A systematic review and meta‐analysis
Authors: Hu Fei‐Hong , Zhao Dan‐Yan , Fu Xue‐Lei , Zhang Wan‐Qing , Tang Wen , Hu Shi‐Qi , Shen Wang‐Qin , Chen Hong‐Lin 
Published: November 2022

AbstractObjectiveAlthough excess mortality, especially suicide, is a critical trait in people living with HIV, consensus about gender differences in these areas is lacking. We conducted meta‐analyses to examine gender differences in suicidal ideation, suicide attempts, and suicide death among people living with HIV.MethodsWe systematically searched PubMed and Web of Science for studies written in English. In this review, suicide among people living with HIV includes suicide death, suicidal ideation, and suicide attempts. Studies reporting the suicide prevalence among males and females living with HIV were eligible for inclusion in our review. Odds ratios (ORs) and 95% confidence intervals (CIs) served as the effect size index. Fixed‐effects or random‐effects meta‐analyses were chosen based on the size of the heterogeneity.ResultsA total of 27 studies comprising 801 017 participants from 11 countries were included in the meta‐analysis. The overall prevalence of suicidal ideation was 18.0% (95% CI 13.3%–22.8%) in males and 20.8% (95% CI 16.4%–25.1%) in females, and there was a statistically significant higher risk of suicidal ideation in females living with HIV (OR 1.30; 95% CI 1.09–1.56; p < 0.05). The overall prevalence of suicide attempts was 16.8% (95% CI 9.0%–24.5%) in males and 24.7% (95% CI 12.4%–37.1%) in females, and there was a statistically significant higher risk of suicide attempts in females living with HIV (OR 1.34; 95% CI 1.02–1.75; p < 0.05). The pooled prevalence of suicide death was 1.2% (95% CI 0.5%–1.9%) among males and 0.2% (95% CI 0.1%–0.3%) among females, and the risk of suicide death between genders was not statistically significant (OR 0.78; 95% CI 0.50–1.24; p = 0.298).ConclusionsThere were gender differences in suicidal ideation and suicide attempts among people living with HIV. Females living with HIV were more likely to experience suicidal ideation and make suicide attempts, but there were no statistically significant gender differences in suicide death. Appropriate initiatives to optimize the recognition, treatment, and management suicide behaviours of males and females living with HIV may narrow this gender gap.