bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Trends in Postpartum Opioid Prescribing, Opioid Use, and Pain Control Satisfaction
Authors: Badreldin Nevert , DiTosto Julia D. , Grobman William , Yee Lynn M. 
Published: March 2022

Objective The objective was to assess temporal trends in postpartum opioid prescribing, opioid use, and pain control satisfaction.
Study Design This is a prospective observational study of postpartum patients who delivered at a large tertiary care center (May 2017–July 2019). Inpatient patients were screened for eligibility; those meeting eligibility criteria who used inpatient opioids were approached for prospective survey participation which probed inpatient and outpatient postpartum pain control. The amount of opioids used during inpatient hospitalization and the amount of opioids prescribed at discharge were obtained from medical records. The primary outcome was the difference in opioid prescribing at discharge over time, measured by (1) the proportion of participants who received an opioid prescription at discharge and (2) for those who received an opioid prescription, the total morphine milligram equivalents of the prescription. Additional outcomes were inpatient and outpatient opioid use and patient-reported satisfaction with postpartum pain control. Trends over time were evaluated using nonparametric tests of trend.
Results Of 2,503 postpartum patients screened for eligibility, a majority (N = 1,425; 60.8%) did not use an opioid as an inpatient. Over the study period, there was a significant decline in the proportion of patients who used an opioid while inpatient (z-score =  − 11.8; p < 0.01). Among these participants enrolled in the prospective survey study (N = 494), there was a significant decline over time in the amount of inpatient opioid use (z-score =  − 2.4; p = 0.02), the proportion of participants who received an opioid prescription upon discharge (z-score =  − 8.2; p < 0.01), and, when an opioid was prescribed at discharge, the total prescribed morphine milligram equivalents (z-score =  − 4.3; p < 0.01). Both inpatient and outpatient satisfactions with pain control were unchanged over this time (z-score = 1.1, p = 0.27; z-score = 1.1, p = 0.29, respectively).
Conclusion In this population, both the frequency and amount of opioid use in the postpartum period declined from 2017 to 2019. This decrease in opioid prescribing was not associated with changes in patient-reported satisfaction with pain control.
Key Points
The ADA (Age-D-Dimer-Albumin) Score to Predict Thrombosis in SARS-CoV-2
Authors: Violi Francesco , Pignatelli Pasquale , Vestri Anna Rita , Spagnoli Alessandra , Cipollone Francesco , Ceccarelli Giancarlo , Oliva Alessandra , Amitrano Maria , Pirro Matteo , Taliani Gloria , Cangemi Roberto , Lichtner Miriam , Pugliese Francesco , Falcone Marco , D'Ardes Damiano , Venditti Mario , Mastroianni Claudio Maria , Loffredo Lorenzo ,   the ADA GROUP
Published: March 2022

Abstract
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related pneumonia is associated with venous and arterial thrombosis. Aim of the study was to find out a new score for predicting thrombosis in patients with SARS-CoV-2.
Methods We included a cohort of 674 patients affected by SARS-CoV-2, not requiring intensive care units, and followed-up during the hospitalization until discharge. Routine analyses performed at in-hospital admission included also serum albumin and D-dimer while arterial and venous thromboses were the endpoints of the study.
Results During the follow-up, 110 thrombotic events were registered; patients with thrombotic events were older and had lower albumin and higher D-dimer, compared with thrombotic event-free ones. On multivariable logistic regression with step-by-step procedure age, serum albumin, and D-dimer were independently associated with thrombotic events. The linear combination of age, D-dimer, and albumin allowed to build-up the ADA (age-D-dimer-albumin) score, whose area under the curve (AUC) was 0.752 (95% confidence interval [CI], 0.708–0.795). ADA score was internally validated by bootstrap sampling procedure giving an AUC of 0.752 (95% CI: 0.708–0.794).
Conclusion Combination of age, D-dimer, and albumin in the ADA score allows identifying SARS-CoV-2 patients at higher risk of thrombotic events.
Associations of Hemostatic Variables with Cardiovascular Disease and Total Mortality: The Glasgow MONICA Study
Authors: Lowe Gordon D. O. , Peters Sanne A. E. , Rumley Ann , Tunstall-Pedoe Hugh , Woodward Mark 
Published: March 2022

AbstractThe associations of plasma levels of hemostatic factors, other than fibrinogen, with risks of cardiovascular disease (CVD) and all-cause mortality are not well defined. In two phases of the Glasgow MONICA study, we assayed coagulation factors (VII, VIII, IX, and von Willebrand factor), coagulation inhibitors (antithrombin, protein C, protein S), coagulation activation markers (prothrombin fragment 1 + 2, thrombin–antithrombin complexes, D-dimer), and the fibrinolytic factors, tissue plasminogen activator (t-PA) antigen and plasminogen activator inhibitor type 1. Over 15 to 20 years, we followed up between 382 and 1,123 men and women aged 30 to 74 years, without baseline CVD, for risks of CVD and mortality. Age- and sex-adjusted hazard ratios (HRs) for CVD (top third vs bottom third) were significant only for factor VIII (1.30; 95% confidence interval [CI], 1.06–1.58) and factor IX (1.18; 95% CI, 1.01–1.39); these HRs were attenuated by further adjustment for CVD risk factors: 1.17 (95% CI, 0.94–1.46) and 1.07 (95% CI, 0.92–1.25), respectively. In contrast, factor VIII (HR, 1.63; 95% CI, 1.35–1.96), D-dimer (HR, 2.34; 95% CI, 1.26–4.35), and t-PA (HR, 2.81; 95% CI, 1.43–5.54) were strongly associated with mortality after full risk factor adjustment. Further studies, including meta-analyses, are required to assess the associations of these hemostatic factors with the risks of stroke and heart disease and causes of mortality.
Screening of Perinatal Depression Using the Edinburgh Postpartum Depression Scale
Authors: Oliveira Tenilson Amaral , Luzetti Guilherme Guarany Cardoso Magalhães , Rosalém Márcia Maria Auxiliadora , Mariani Neto Corintio 
Published: March 2022

Abstract
Objective To detect depression during pregnancy and in the immediate postpartum period using the Edinburgh postpartum depression scale (EPDS).
Methods Cross sectional study of 315 women, aged between 14 and 44 years, who received perinatal care at the Leonor Mendes de Barros Hospital, in São Paulo, between July 1st, 2019 and October 30th, 2020. The cutoff point suggesting depression was ≥ 12.
Results The screening indicated 62 (19.7%) patients experiencing depression. Low family income, multiparity, fewer prenatal appointments, antecedents of emotional disorders, dissatisfaction with the pregnancy, poor relationship with the partner, and psychological aggression were all risk factors associated with depression in pregnancy or in the immediate postpartum period. Antecedents of depression and psychology aggression during pregnancy were significant variables for predicting perinatal depression in the multivariate analysis.
Conclusion There is a significant association between the occurrence of perinatal depression and the aforementioned psychosocial factors. Screening patients with the EPDS during perinatal and postpartum care could facilitate establishing a line of care to improve the wellbeing of mother and infant.
Prospective Determination of Orbital Perfusion Dominance before Intra-Arterial Chemotherapy for Retinoblastoma Using Time-of-Flight Magnetic Resonance Angiography
Authors: Monroe Eric J. , Otjen Jeffrey P. , Wright Jason N. , Perez Francisco A. , Chick Jeffrey Forris Beecham , Hallam Danial K. , Ferguson Mark R. 
Published: March 2022

AbstractIntra-arterial chemotherapy (IAC) represents a mainstay in the treatment of retinoblastoma. In a minority of cases, the external carotid artery (ECA) serves as the dominant supply to the central retinal artery and is associated with prolonged fluoroscopy times and higher intraprocedural radiation doses. The aim of this study was to evaluate the utility of time-of-flight (TOF) magnetic resonance angiography (MRA) for prospective determination of internal (ICA) versus ECA dominance for procedural planning. Between April 2017 and December 2020 (44 months), staging MR prior to IAC for retinoblastoma included variant spatial saturation band position TOF angiography. Exams were then retrospectively reviewed for concordance of ICA versus ECA dominance between the two modalities. Eight consecutive patients were included in the study. Mean patient age at time of diagnosis was 20.3 ± 10.7 months (range: 2.7–33.2 months). Ten affected eyes were included (2 cases of bilateral disease), with stage D disease in eight eyes and stage B disease in two eyes. MRA techniques demonstrated antegrade ophthalmic artery (OA) flow in 9/10 (90%) of affected eyes. Subsequent catheter angiography confirmed ICA dominant supply in 9/9 (100%). For a single affected eye (10%), the OA was demonstrated as orthotopic by T2 flow void, nonvisualized on anterior saturation TOF sequences, and faintly visualized on posterior saturation TOF sequences. Aggregate MRA to catheter angiographic concordance was 10/10 (100%). Variant saturation TOF MRA predicts ICA versus ECA dominant supply to the central retinal artery in retinoblastoma.
The Effects of COVID-19 on Oxidative Stress and Antioxidant Defense Mechanism in Children
Authors: Aydin Orkun , Kaynak Mustafa O. , Sabuncuoglu Suna , Girgin Gozde , Oygar Pembe D. , Ozsurekci Yasemin , Teksam Ozlem 
Published: March 2022

Abstract
Objective Oxidative stress and antioxidants play an important role in infections' response. We aimed to investigate the potential association between oxidative stress and the pathogenesis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection.
Methods We analyzed oxidant and antioxidant parameters from serum samples of children with novel corona virus disease 2019 (COVID-19) besides demographic and clinical data of children. Serum levels of the 8-hydroxy deoxyguanosine (8-OHdG), protein carbonyl (CO), malondialdehyde (MDA), total glutathione (GSH), superoxide dismutase (SOD), catalase (CT), and glutathione peroxidase (GPx) enzyme activities were evaluated and compared between groups.
Results A total of 96 children were evaluated, including 32 patients with confirmed COVID-19 (group 1), 35 patients with symptomatic infections without COVID-19 (group 2), and 29 healthy patients as a control group (group 3). Group 1 included 7 (21.8%) asymptomatic, 22 (68.7%) mild, and 3 (9.5%) moderate patients according to the severity of the disease. In all groups, there were no significant differences in oxidative stress and antioxidant parameter levels (p > 0.05). Furthermore, no statistical difference was found when the parameters of patients with COVID-19 and healthy children were evaluated according to disease course.
Conclusion Serum levels of oxidant and antioxidant parameters were similar in children infected with SARS-CoV-2 and other infectious agents. However, further studies, including children with severe to critical disease, are necessary to characterize the oxidative stress, antioxidants, cytokine responses in COVID-19, and elucidate the pathogenesis.
Treatment of Medial Shoulder Joint Instability by Stabilization with an Arthroscopically Guided Prosthetic Ligament: A Cadaveric Feasibility Study in Dogs
Authors: Llido Marie , Livet Véronique , Carozzo Claude , Viguier Éric , Cachon Thibaut 
Published: March 2022

Abstract
Objective The aim of this study was to assess the feasibility and efficiency of an arthroscopically guided ligamentoplasty of the medial glenohumeral ligament to treat medial shoulder joint instability.
Study Design Six Beagle cadavers were used (12 limbs). Both arms of the medial glenohumeral ligament were severed using arthroscopic guidance. Arthroscopically guided reconstruction of the ligament was performed. Threaded sutures were fixed with a bone anchor on the medial aspect of the glenoidal cavity of the scapula, passed through a humeral tunnel and finally tensioned with a suture button on lateral aspect of the humerus. Shoulder abduction angles were measured before and after the section of the medial glenohumeral ligament, and following the surgery. Two orthogonal radiographic projections and dissections were performed after each procedure to grade the placement of the implants.
Results Surgical repairs were achieved in 10 out of 12 limbs. The abduction angles after repair with ligamentoplasty were not significantly different from the abduction angles measured before the section of the medial glenohumeral ligament.
Conclusion Arthroscopically guided ligamentoplasty with a scapular bone anchor and a humeral drilling tunnel is feasible in cadavers, and efficient to restore acutely shoulder abduction angle in a minimally invasive manner. Further clinical studies are required to assess in vivo results.
Effect of Preferred Volume Setting on Speech Audibility in Different Hearing Aid Circuits
Authors: Souza Pamela E. , Kitch Virginia J. 
Published: March 2022

AbstractThis study compared preferred volume setting for linear peak clipping, compression limiting, and wide dynamic range compression (WDRC) amplification and quantified speech audibility at the preferred volume setting for each amplification type. Ten listeners with mild-to-moderate hearing loss were fitted monaurally with a behind-the-ear hearing aid programmed sequentially with WDRC, compression limiting, and linear peak clipping amplification. Speech was presented in quiet and in noise at a range of input levels. In each condition, the listener adjusted the volume for maximum clarity. Signal levels were measured using a probe microphone system. There was no significant difference in speech audibility between amplification strategies for any speech level regardless of the presence or absence of background noise. These results imply that the improved audibility advantage of WDRC over linear amplification demonstrated in controlled environments may not be maintained in situations where the hearing aid wearer controls the volume.
Abbreviations: AAI = Aided Audibility Index, AI = Articulation Index, ANOVA = analysis of variance, NAL-R = National Acoustic Laboratories-Revised, SIR = Speech Intelligibility Rating, WDRC = wide dynamic range compression
Evaluation of a Revised Speech in Noise (RSIN) Test
Authors: Cox Robyn M. , Gray Ginger A. , Alexander Genevieve C. 
Published: March 2022

AbstractA revised version of the Speech in Noise (SIN) test was developed by reallocating the recorded test material on the compact disc into different lists (blocks). The goal was to increase the equivalence and reliability of the test blocks to enhance their usefulness in research settings. The Revised Speech in Noise test has four blocks of sentences. Each block comprises twice as many sentences as in the original SIN test. There are also practice sentences for each condition. Forty-two elderly subjects with normal hearing for their age and gender provided data on the equivalence of the new test blocks. The remaining inequalities in mean scores were mostly eliminated using score weighting. Critical differences were developed to promote interpretation of scores from the same individual under different conditions. The revisions substantially improved the equivalence of test blocks and their sensitivity to performance changes. Increased test time is the associated drawback.
Abbreviations: CD = critical difference, MDB = modified dual block, RAU = rationalized arcsine unit, RSIN = Revised Speech in Noise test, SBR = signal-to-babble ratio, SBR-50 = the signal-to-babble ratio corresponding to a score of 50 percent correct, SIN = Speech in Noise test, WRAU = weighted rationalized arcsine unit
Distortion-Product Otoacoustic Emissions in Schoolchildren: Effects of Ear Asymmetry, Handedness, and Gender
Authors: Keogh Tegan , Kei Joseph , Driscoll Carlie , Smyth Veronica 
Published: March 2022

AbstractThe present study examined effects of ear asymmetry, handedness, and gender on distortionproduct otoacoustic emissions (DPOAEs) obtained from schoolchildren. A total of 1003 children (528 boys and 475 girls), with a mean age of 6.2 years (SD = 0.4, range = 5.2–7.9 years), were tested in a quiet room at their schools using the GSI-60 DPOAE system. A distortion-product (DP)-gram was obtained for each ear, with f2 varying from 1.1 to 6.0 kHz and the ratio of f2/f 1 at 1.21. The signal-to-noise ratios (SNRs) (DPOAE amplitude minus the mean noise floor) at the tested frequencies 1.1,1.5, 1.9, 2.4, 3.0, 3.8, 4.8, and 6.0 kHz were measured. The results revealed a small but significant difference in SNR between ears, with right ears showing a higher mean SNR than left ears at 1.9, 3.0, 3.8, and 6.0 kHz. At these frequencies, the difference in mean SNR between ears was less than 1 dB. A significant gender effect was also found. Girls exhibited a higher SNR than boys at 3.8, 4.8, and 6.0 kHz. The difference in mean SNR, as a result of the gender effect, was about 1 to 2 dB at these frequencies. There was no significant difference in mean SNR between left-handed and right-handed children for all tested frequencies.
Abbreviations: DPOAE = distortion-product otoacoustic emission, OAE = otoacoustic emission, SNR = signal-to-noise ratio, SOAE = spontaneous otoacoustic emission, TEOAE = transient evoked otoacoustic emission
On the selection of relevant historical demand data for revenue management applied to transportation
Authors: Ahlberg Ernst , Mirkina Irina , Olsson Alfred , Söyland Christian , Carlsson Lars 
Published: March 2022

AbstractThe success of revenue management models depends to a large extent on the quality of historical data used to forecast future bookings. Several theoretical models and best practices of handing historical data have been developed over the years, that all rely on assumptions about underlying distribution and seasonality in the historical data. In this paper, we describe a novel method that compares the fingerprints of the departure to optimise and selects historical departures without making assumptions on data distribution or seasonality. By evaluating the method at the departure level and using the Nemenyi rank test, we show the method’s application in the ferry transportation business and discuss its advantages.
An unproblematized truth: Foucault, biopolitics, and the making of a sociological canon
Authors: Meloni Maurizio 
Published: March 2022

AbstractFoucault’s argument that a major break occurred in the nature of power in the European Eighteenth century—an unprecedented socialization of medicine and concern for the health of bodies and populations, the birth of biopolitics—has become since the 1990s a dominant narrative among sociologists but is rarely if ever scrutinized in its premises. This article problematizes Foucault’s periodization about the politics of health and the way its story has been solidified into an uncritical account. Building on novel historiographic work, it challenges the modernist bias of histories of biopolitics and public health and considers an earlier and more plural history of collective practices of health of which the story told by Foucault is just one important episode. Finally, it discusses the implications of this revised model for wider sociological debates on the link between modernity, health and the body.
Voices from the past: economic and political vulnerabilities in the making of next generation EU
Authors: Armingeon Klaus , de la Porte Caroline , Heins Elke , Sacchi Stefano 
Published: March 2022

AbstractIn this article, we show that Next Generation EU (NGEU) is mainly a response to the economic and political imbalances left over from the Eurozone crisis. It is a pre-emptive intervention, especially targeted at structurally weak economies with rising Euroscepticism, to avoid costly ex-post bailouts as in the Great Recession. We demonstrate, using quantitative analysis, that pre-existing vulnerabilities, rather than the impact of the pandemic, drove the allocation of NGEU resources: per capita grants largely correspond to past economic vulnerabilities, as well as to political ones. Countries most vulnerable to another adjustment by austerity after the COVID-19 economic crisis receive most resources. Also, countries with strong anti-EU sentiments are entitled to larger NGEU grants per capita. In contrast, grants are not correlated with the severity of the health crisis. Then, we show the domestic relevance of economic and political vulnerabilities through qualitative case studies of national political debates and domestic positions on NGEU in Italy, Germany and the Netherlands. Despite its innovative traits, NGEU is a politically constrained solution to address the mess from the previous decade, and as such, it is a Janus solution: promising a fresh start, but haunted by the past.
Testing the performance of secondary anvils shaped with focused ion beam from the single-crystal diamond for use in double-stage diamond anvil cells
Authors: Khandarkhaeva Saiana , Fedotenko Timofey , Krupp Alena , Glazyrin Konstantin , Dong Weiwei , Liermann Hanns-Peter , Bykov Maxim , Kurnosov Alexander , Dubrovinskaia Natalia , Dubrovinsky Leonid 
Published: March 2022

The success of high-pressure research relies on the inventive design of pressure-generating instruments and materials used for their construction. In this study, the anvils of conical frustum or disk shapes with flat or modified culet profiles (toroidal or beveled) were prepared by milling an Ia-type diamond plate made of a (100)-oriented single crystal using the focused ion beam. Raman spectroscopy and synchrotron x-ray diffraction were applied to evaluate the efficiency of the anvils for pressure multiplication in different modes of operation: as single indenters forced against the primary anvil in diamond anvil cells (DACs) or as pairs of anvils forced together in double-stage DACs (dsDACs). All types of secondary anvils performed well up to about 250 GPa. The pressure multiplication factor of single indenters appeared to be insignificantly dependent on the shape of the anvils and their culets’ profiles. The enhanced pressure multiplication factor found for pairs of toroidally shaped secondary anvils makes this design very promising for ultrahigh-pressure experiments in dsDACs.
Global patterns in the predator satiation effect of masting: A meta-analysis
Authors: Zwolak Rafał , Celebias Paulina , Bogdziewicz Michał 
Published: March 2022

SignificanceMasting, or synchronous production of large seed crops, is widespread among plants. The predator satiation hypothesis states that masting evolved to overwhelm seed predators with an excess of food. Yet, this popular explanation faced few rigorous tests. We conducted a meta-analysis of studies that related the magnitude of seed production to the intensity of seed predation. Our results validate certain theoretical notions (e.g., that predator satiation is more effective at higher latitudes) but challenge others (e.g., that specialist and generalist consumers differ in the type of functional response to masting). We also found that masting is losing its ability to satiate consumers, probably because global warming affected masting patterns. This shift might considerably impair the reproduction of masting plants.