bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum immanants, double Young–Capelli bitableaux and Schur shifted symmetric functions
Authors: Brini A. , Teolis A. 
Published: June 2022

In this paper, we introduced two classes of elements in the enveloping algebra [Formula: see text]: the double Young–Capelli bitableaux [Formula: see text] and the central Schur elements [Formula: see text], that act in a remarkable way on the highest weight vectors of irreducible Schur modules. Any element [Formula: see text] is the sum of all double Young–Capelli bitableaux [Formula: see text], [Formula: see text] row (strictly) increasing Young tableaux of shape [Formula: see text]. The Schur elements [Formula: see text] are proved to be the preimages — with respect to the Harish-Chandra isomorphism — of the shifted Schur polynomials [Formula: see text]. Hence, the Schur elements are the same as the Okounkov quantum immanants, recently described by the present authors as linear combinations of Capelli immanants. This new presentation of Schur elements/quantum immanants does not involve the irreducible characters of symmetric groups. The Capelli elements [Formula: see text] are column Schur elements and the Nazarov elements [Formula: see text] are row Schur elements. The duality in [Formula: see text] follows from a combinatorial description of the eigenvalues of the [Formula: see text] on irreducible modules that is dual (in the sense of shapes/partitions) to the combinatorial description of the eigenvalues of the [Formula: see text]. The passage [Formula: see text] for the algebras [Formula: see text] is obtained both as direct and inverse limit in the category of filtered algebras, via the Olshanski decomposition/projection.
Targeting Therapeutic Resistance and Multinucleate Giant Cells in CCNE1-Amplified HR-Proficient Ovarian Cancer
Authors: Bai Shoumei , Taylor Sarah E. , Jamalruddin Mohd Azrin , McGonigal Stacy , Grimley Edward , Yang Dongli , Bernstein Kara A. , Buckanovich Ronald J. 
Published: June 2022

AbstractApproximately 20% of high-grade serous ovarian cancers (HGSOC) have CCNE1 amplification. CCNE1-amplified tumors are homologous recombination (HR) proficient and resistant to standard therapies. Therapy resistance is associated with increased numbers of polyploid giant cancer cells (PGCC). We sought to identify new therapeutic approaches for patients with CCNE1-amplified tumors. Using TCGA data, we find that the mTOR, HR, and DNA checkpoint pathways are enriched in CCNE1-amplified ovarian cancers. Furthermore, Interactome Mapping Analysis linked the mTOR activity with upregulation of HR and DNA checkpoint pathways. Indeed, we find that mTOR inhibitors (mTORi) downregulate HR/checkpoint genes in CCNE1-amplified tumors. As CCNE1-amplified tumors are dependent on the HR pathway for viability, mTORi proved selectively effective in CCNE1-amplified tumors. Similarly, via downregulation of HR genes, mTORi increased CCNE1-amplifed HGSOC response to PARPi. In contrast, overexpression of HR/checkpoint proteins (RAD51 or ATR), induced resistance to mTORi. In vivo, mTORi alone potently reduced CCNE1-amplified tumor growth and the combination of mTORi and PARPi increased response and tumor eradication. Tumors treated with mTORi demonstrated a significant reduction in ALDH+ PGCCs. Finally, as a proof of principle, we identified three patients with CCNE1 amplified tumors who were treated with an mTORi. All three obtained clinical benefits from the therapy. Our studies and clinical experience indicate mTORi are a potential therapeutic approach for patients with CCNE1-amplified tumors.
Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma
Authors: Castellano Gina M. , Zeeshan Saman , Garbuzenko Olga B. , Sabaawy Hatim E. , Malhotra Jyoti , Minko Tamara , Pine Sharon R. 
Published: June 2022

Abstract
Only a small percentage (&lt;1%) of patients with late-stage lung squamous cell carcinoma (LUSC) are eligible for targeted therapy. Because PI3K/AKT/mTOR signaling, particularly Phosphatidylinositol 3-kinase CA (PIK3CA), is dysregulated in two-thirds of LUSC, and DNA damage response pathways are enriched in LUSC, we tested whether CC-115, a dual mTORC1/2 and DNA-PK inhibitor, sensitizes LUSC to chemotherapy. We demonstrate that CC-115 synergizes with carboplatin in six of 14 NSCLC cell lines, primarily PIK3CA-mutant LUSC. Synergy was more common in cell lines that had decreased basal levels of activated AKT and DNA-PK, evidenced by reduced P-S473-AKT, P-Th308-AKT, and P-S2056-DNA-PKcs. CC-115 sensitized LUSC to carboplatin by inhibiting chemotherapy-induced AKT activation and maintaining apoptosis, particularly in PIK3CA-mutant cells lacking wild-type (WT) TP53. In addition, pathway analysis revealed that enrichments in the IFNα and IFNγ pathways were significantly associated with synergy. In multiple LUSC patient-derived xenograft and cell line tumor models, CC-115 plus platinum-based doublet chemotherapy significantly inhibited tumor growth and increased overall survival as compared with either treatment alone at clinically relevant dosing schedules. IHC and immunoblot analysis of CC-115–treated tumors demonstrated decreased P-Th308-AKT, P-S473-AKT, P-S235/236-S6, and P-S2056-DNA-PKcs, showing direct pharmacodynamic evidence of inhibited PI3K/AKT/mTOR signaling cascades. Because PI3K pathway and DNA-PK inhibitors have shown toxicity in clinical trials, we assessed toxicity by examining weight and numerous organs in PRKDC-WT mice, which demonstrated that the combination treatment does not exacerbate the clinically accepted side effects of standard-of-care chemotherapy. This preclinical study provides strong support for the further investigation of CC-115 plus chemotherapy in LUSC.
Incentivizing Demand for Supply-Constrained Care: Institutional Birth in India
Authors: Andrew Alison , Vera-Hernández Marcos 
Published: June 2022

Abstract
If overcrowding harms health care quality, the impacts of encouraging more people to use services are not obvious. Impacts will depend on whether marginal entrants benefit and whether they benefit enough to offset the congestion externalities imposed on inframarginal users. We develop a general-equilibrium model that formalizes these ideas. We examine them empirically by studying JSY, a program in India that paid women to give birth in medical facilities. We find evidence that JSY increased perinatal mortality in areas with low health-system capacity, was particularly harmful in more-complex births, reduced the quality of facilities' postnatal care, and generated harmful spillovers onto other services.
Moved to Vote: The Long-Run Effects of Neighborhoods on Political Participation
Authors: Chyn Eric , Haggag Kareem 
Published: June 2022

Abstract
How does one's childhood neighborhood shape political engagement later in life? We study voting rates of children who were displaced by public housing demolitions and moved to higher opportunity areas using housing vouchers. Those displaced during childhood had 11% (2 pp) higher participation in the 2016 Presidential election and were 10% (2.9 pp) more likely to vote in any general election. We argue that the results are unlikely to be driven by changes in incarceration or parental outcomes but rather by political socialization or improvements in education and earnings. These results suggest that housing assistance programs may reduce inequality in political participation.
The influence of L2 experience on L1 speech perception: Evidence from Mandarin–English bilinguals
Authors: Zhao Rong , Jiao Lu , Wang Min , Wei Hang 
Published: June 2022

Aims: Previous studies have documented that consonants contribute more to lexically related processes than vowels in English, whereas an opposite pattern occurs in Mandarin Chinese processing. The current study aims to examine how the long-term learning of English (L2) influences Mandarin (L1) consonant, vowel, and tone perception in bilingual adults. It also attempts to examine the multi–competence theory at the level of speech perception. Methodology: A total of 73 Mandarin–English bilinguals with different L2 proficiency levels performed the L1 syllable perception task in an active oddball paradigm. The deviant syllables differed from the standard in consonant, vowel, or tone. Participants were asked to press a button whenever they heard a different syllable. Data and analysis: The reaction time and accuracy of each deviant syllable were recorded by E-prime 2.0. These data were analyzed using mixed-effects models. Findings/conclusions: Results showed that the relative role of vowel was the strongest, followed by consonant, and then by tone in L1 speech perception. The pattern of their relative roles/phonological bias was not influenced by L2 proficiency, indicating that the phonological bias in L1 speech perception is not affected by a transfer from non-native to native processing, but determined by the acoustic/phonological cues and lexical information carried by consonant, vowel, and tone. However, the perceptual sensitivity to L1 speech increased with L2 proficiency, demonstrating a positive L2 effect on L1 at the level of speech perception. Originality: The current study first investigated the influence of L2 experience on L1 phonological bias in bilinguals whose first and second languages were typologically distant. Significance/implications: Our findings lend support to the multi-competence theory and extend it to the level of speech perception.
Outcomes of older patients with diffuse large B-cell lymphoma treated with R-CHOP: 10-year follow-up of the LNH03-6B trial
Authors: Camus Vincent , Belot Aurélien , Oberic Lucie , Sibon David , Ghesquières Hervé , Thieblemont Catherine , Fruchart Christophe , Casasnovas Olivier , Michot Jean-Marie , Molina Thierry Jo , Bosly André , Joubert Clémentine , Haioun Corinne , Nicolas-Virelizier Emmanuelle , Feugier Pierre , Fitoussi Olivier , Delarue Richard , Tilly Hervé 
Published: June 2022

Abstract
The LNH03-6B trial was a phase 3 randomized trial evaluating the efficacy of first-line rituximab, cyclophosphamide, doxorubicine, vincristine and prednisone (R-CHOP) delivered every 2 weeks (R-CHOP14) or 3 weeks (R-CHOP21) in patients with diffuse large B-cell lymphoma (DLBCL) aged 60 to 80 years with an aaIPI (age-adjusted International Prognostic Index) score ≥1 (registered as NCT00144755). We implemented a prospective long-term follow-up program at the end of this trial. The primary endpoints were progression-free survival (PFS) and overall survival (OS). Relapse patterns, PFS and OS after the first progression (PFS2 and OS2) were secondary endpoints. LNH03-6B was registered with ClinicalTrials.gov #NCT00144755. In the LNH03-6B trial, 304 and 296 patients were assigned to receive 8 cycles of R-CHOP14 or R-CHOP21, respectively. Long-term follow-up data were investigated for 256 of 384 (67%) patients still alive at the primary analysis. With a median follow-up of 10.1 years, 213 patients progressed, and 140 patients died without progression. The 10-year PFS was 40.4% (95% confidence interval, 35.9-44.9). Ten-year OS was based on 302 deaths and estimated at 50% (43-56). Of the 213 patients, 105 (49%) progressed after second-line therapy, and 77 patients died without a second progression (36%). The 1-year PFS2 and 1-year OS2 were estimated at 37.9% (95% confidence interval, 31.4-44.5) and 55.8% (95% confidence interval, 48.8-62.2), respectively. Ten years after randomization, the outcomes of patients treated for DLBCL were similar according to PFS and OS between the RCHOP-14 and R-CHOP21 groups. Progression or relapse led to poor prognosis after second-line chemotherapy in the pre CAR-T-cell era. Novel approaches in first-line and alternative treatments in second-line treatments are warranted in this population.
Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells
Authors: Rabcuka Julija , Blonski Slawomir , Meli Athinoula , Sowemimo-Coker Samuel , Zaremba Damian , Stephenson Daniel , Dzieciatkowska Monika , Nerguizian David , Cardigan Rebecca , Korczyk Piotr M. , Smethurst Peter A. , D’Alessandro Angelo , Swietach Pawel 
Published: June 2022

AbstractStored red blood cells (RBCs) incur biochemical and morphological changes, collectively termed the storage lesion. Functionally, the storage lesion manifests as slower oxygen unloading from RBCs, which may compromise the efficacy of transfusions where the clinical imperative is to rapidly boost oxygen delivery to tissues. Recent analysis of large real-world data linked longer storage with increased recipient mortality. Biochemical rejuvenation with a formulation of adenosine, inosine, and pyruvate can restore gas-handling properties, but its implementation is impractical for most clinical scenarios. We tested whether storage under hypoxia, previously shown to slow biochemical degradation, also preserves gas-handling properties of RBCs. A microfluidic chamber, designed to rapidly switch between oxygenated and anoxic superfusates, was used for single-cell oxygen saturation imaging on samples stored for up to 49 days. Aliquots were also analyzed flow cytometrically for side-scatter (a proposed proxy of O2 unloading kinetics), metabolomics, lipidomics, and redox proteomics. For benchmarking, units were biochemically rejuvenated at 4 weeks of standard storage. Hypoxic storage hastened O2 unloading in units stored to 35 days, an effect that correlated with side-scatter but was not linked to posttranslational modifications of hemoglobin. Although hypoxic storage and rejuvenation produced distinct biochemical changes, a subset of metabolites including pyruvate, sedoheptulose 1-phosphate, and 2/3 phospho-d-glycerate, was a common signature that correlated with changes in O2 unloading. Correlations between gas handling and lipidomic changes were modest. Thus, hypoxic storage of RBCs preserves key metabolic pathways and O2 exchange properties, thereby improving the functional quality of blood products and potentially influencing transfusion outcomes.
A study to investigate the prevalence of headache disorders and migraine among people registered in a health insurance association in Japan
Authors: Sakai Fumihiko , Hirata Koichi , Igarashi Hisaka , Takeshima Takao , Nakayama Takeo , Sano Hiromi , Kondo Hiroyuki , Shibasaki Yoshiyuki , Koga Nobuyuki 
Published: June 2022

Abstract
Background
Migraine is a chronic disease characterized by episodic headache attacks. No recent studies have, however been conducted on the epidemiology of migraine or the treatment landscape in Japan. This study was conducted as a fact-finding survey using medical claims data and an online survey on migraine and headaches, conducted among members of health insurance associations with the objective of gaining an understanding of migraine prevalence and the treatment status in Japan.

Methods
The study methodology utilized a unique approach of combined data sources. The data sources used in this study are medical claims data and linked online survey data provided by DeSC Healthcare Inc (DeSC). The primary outcomes (from survey responses) were: the overall number and proportion of migraine patients; and the overall prevalence of migraine, stratified by age and sex. The secondary outcomes (from survey responses) were use of medical care; and clinical features/headache symptoms. The analysis population included all individuals who had response data for surveys conducted by DeSC. The online survey data and medical claims data were summarized.

Results
The data population comprised 21,480 individuals. On the basis of the survey results, including probable cases, the overall prevalence of migraine was 3.2%. The highest prevalence of migraine was observed in patients aged 30–39 years. The prevalence of migraine in women was 4.4 times higher than in men. The percentage of migraine patients who had not been seen by a doctor was 81.0%. More than 80% of patients were taking over-the-counter drugs and 6.1% took prescription medicines only. Approximately 52.9% of patients considered that the intensity of pain symptoms was severe. Moreover, the majority of patients (72.9%) considered that the impairment of daily life activities was of moderate or severe degree.

Conclusions
In Japan, the percentage of people with migraine who did not receive medical attention is as high as 80%. Additionally, the majority of patients tend to endure symptoms and continue with everyday activities. With innovative treatment approaches becoming available it is necessary to disseminate information that migraine is not a simple headache but an illness that requires medical treatment and consultation.
A structural equation model linking health literacy, self efficacy and quality of life in adults with coronary heart disease
Authors: Du Shaoying , Feng Zhimin , Wang Wen , Tian Licong , Wang Yan 
Published: June 2022

Abstract
Background
Cardiovascular disease is the world major cause of death. There is sufficient evidence that patients with coronary heart disease (CHD) experience poor quality of life. Health literacy and self efficacy are modifiable psychosocial factors that could affect quality of life, and these factors should be considered as targets for intervention. As the relationships among health literacy, self efficacy, and quality of life in the CHD population have not been well understood. Thus, we constructed the structure equation model in these valuables.

Methods
A cross-sectional study of a convenience sample among 200 patients with CHD were participated from outpatient clinics in three tertiary general hospitals in Baoding City in mainland China, from December 2018 to June 2019. Data regarding demographic features, health literacy, self efficacy and quality of life were assessed. A structure equation model was used to construct and validate the pathways.

Results
The mean age of the study sampled patients was 65.37 years old. The average level of health literacy, self efficacy and quality of life were 9.6 ± 3.5, 28.8 ± 13.9 and 381.8 ± 130.1 respectively. Significant associations were observed from health literacy to quality of life, and self efficacy played a partial mediating role between health literacy and quality of life in the CHD population. Health literacy and self efficacy explained for 59.6% of the variance in quality of life.

Conclusions
Health literacy had a direct influence on quality of life, and an indirect influence on quality of life via self efficacy in the patients with CHD.
Experiences and expectation with the use of health data: a qualitative interview study in primary care
Authors: Suija Kadri , Mardo Laura Alexandra , Laidoja Reet , Nahkur Siim , Parvelo Anu , Kalda Ruth 
Published: June 2022

Abstract
Background
Health data is important, however, not always well managed. The aim of this study was to investigate the experiences of patients and primary care physicians, their expectations and the obstacles encountered when using health data – both patient-generated as well as physician-generated.

Methods
We conducted a qualitative interview study. We included adult persons who were ready to talk about the topic. Participants were recruited from primary care. The interviews were recorded using a dictaphone, transcribed verbatim and analysed using a content analysis method.

Results
Altogether, we conducted 14 individual interviews, with patients (n = 7) and with physicians (n = 7). We found that both patients and physicians emphasized the importance of easy access to health data in digital health information systems. However, patients may not always understand medical terminology and physicians found that the quality of medical documents needs inspection. Both parties found that patient-generated data is a useful source of information, and that it should be used more often.

Conclusions
The pandemic has highlighted the value of easy access to health data. The development of a health information system is useful to health care providers and patients, enables the transfer of evidence-based medicine, and supports health literacy.
Factors associated with older persons’ perceptions of dignity and well-being over a three-year period. A retrospective national study in residential care facilities
Authors: Roos Charlotte , Alam Moudud , Swall Anna , Boström Anne-Marie , Hammar Lena Marmstål 
Published: June 2022

Abstract
Background
Dignity and well-being are central concepts in the care of older people, 65 years and older, worldwide. The person-centred practice framework identifies dignity and well-being as person-centred outcomes. Older persons living in residential care facilities, residents, have described that they sometimes lack a sense of dignity and well-being, and there is a need to understand which modifiable factors to target to improve this. The aim of this study was to examine the associations between perceptions of dignity and well-being and the independent variables of the attitudes of staff, the indoor-outdoor-mealtime environments, and individual factors for residents over a three-year period.

Methods
A national retrospective longitudinal mixed cohort study was conducted in all residential care facilities within 290 municipalities in Sweden. All residents aged 65 years and older in 2016, 2017 and 2018 were invited to responded to a survey; including questions regarding self-rated health and mobility, the attitudes of staff, the indoor-outdoor-mealtime environments, safety, and social activities. Data regarding age, sex and diagnosed dementia/prescribed medication for dementia were collected from two national databases. Descriptive statistics and ordinal logistic regression models were used to analyse the data.

Results
A total of 13 763 (2016), 13 251 (2017) and 12 620 (2018) residents answered the survey. Most of them (69%) were women and the median age was 88 years. The odds for satisfaction with dignity did not differ over the three-year period, but the odds for satisfaction with well-being decreased over time. Residents who rated their health as good, who were not diagnosed with dementia/had no prescribed medication for dementia, who had not experienced disrespectful attitudes of staff and who found the indoor-outdoor-mealtime environments to be pleasant had higher odds of being satisfied with aspects of dignity and well-being over the three-year period.

Conclusions
The person-centred practice framework, which targets the attitudes of staff and the care environment, can be used as a theoretical framework when designing improvement strategies to promote dignity and well-being. Registered nurses, due to their core competencies, focusing on person-centred care and quality improvement work, should be given an active role as facilitators in such improvement strategies.