bluuebunny/crossref_metadata_2025_split huggingface dataset:
SERS using nanostar‐in‐cavity structures
Authors: Zalaffi Maria Sole , Ugo Paolo , Marti Almudena , Bowden Bethany M. , Russell Andrea E. , Bartlett Philip N. 
Published: June 2022

AbstractParticle in cavity nanostructures were produced by sedimentation of silver nanostars (AgNSs) onto sphere segment void (SSV) cavity structures produced by electrodeposition of gold around templates formed by assembling close packed monolayer arrays of 220 or 600 nm diameter polystyrene spheres. The resulting AgNS@SSV nanostructures were characterized by scanning electron microscopy and their performance as substrates for surface enhanced Raman spectroscopy (SERS) was examined. The enhancement factors obtained for the different structures were evaluated using benzenethiol as Raman probe, which adsorbs on Ag and Au to form a monolayer with uniform coverage, so allowing the enhancement to be quantified. Higher enhancements were obtained for the AgNSs@SSV substrates as compared with the gold SSV structures. The greatest enhancements were obtained when matching cavity and nanostar dimension so that only one nanostar could be accommodated in the cavity. The AgNS@SSV substrates were then shown to be promising substrates for the highly sensitive detection of dyes and, particularly, for the lake‐pigment cochineal lake, providing useful information and novel analytical tool for application in the field of cultural heritage diagnostics and conservation.
Reverting to a Healthy Diet during Lactation Normalizes Maternal Milk Lipid Content of Diet‐Induced Obese Rats and Prevents Early Alterations in the Plasma Lipidome of the Offspring
Authors: Castillo Pedro , Kuda Ondrej , Kopecky Jan , Pomar Catalina Amadora , Palou Andreu , Palou Mariona , Picó Catalina 
Published: June 2022

ScopeThis study aims to assess in rats whether normalizing maternal diet during lactation prevents the harmful effects of western diet (WD) consumption during the whole perinatal period on the lipidomic profile in maternal milk and offspring plasma.Methods and ResultsControl dams (CON‐dams), fed with standard diet (SD); WD‐dams, fed with WD prior and during gestation and lactation; and reversion dams (REV‐dams), fed as WD‐dams but moved to SD during lactation are followed. Lipidomic analysis is performed in milk and plasma samples from pups. Milk of WD‐dams presents a different triacylglycerol composition and free fatty acid (FA) profile compared to CON‐dams, including an increased ratio of pro‐inflammatory to anti‐inflammatory long‐chain polyunsaturated FA. Such alterations, which are also present in the plasma of their offspring, are widely reversed in the milk of REV‐dams and the plasma of their pups. This is related with the recovery of control adiponectin expression levels in the mammary gland, and the presence of decreased expression of pro‐inflammatory factors.ConclusionImplementing a healthy diet during lactation prevents early alterations in the plasma lipidome of pups associated to the maternal intake of an obesogenic diet, which may be related to the normalization of milk lipid content and the inflammatory state in the mammary gland.
Global optimization point‐set registration based on translation/rotation decoupling for image‐guided surgery applications
Authors: Fu Kexue , Chen Xinrong , Wang Manning 
Published: June 2022

AbstractPurposeIn image‐guided surgery systems, image‐to‐patient spatial registration is to get the spatial transformation between the image space and the actual operating space. Although the image‐to‐patient spatial registration methods using paired point or surface matching are used in some image‐guided neurosurgery systems, the key problem is that the global optimization registration result cannot be achieved. Therefore, this paper proposes a new rotation invariant feature for decoupling rotation and translation space, based on which global optimization point set registration method is proposed.MethodsThe new rotation invariant features, constructed based on the edges and the angles, are the rotation invariant, which has high feature resolution. Some of them are not only the rotation invariant, but also the translation invariant. To obtain the global optimal solution, branch and bound search strategy is used to search the parameter space of the translation and the computational cost is reduced simultaneously. The registration accuracy of the spatial registration method is analyzed by comparing the difference between the estimated transform and the standard transform to calculate the registration error.ResultsTo validate the performance of the spatial registration method proposed, the registration performance was analyzed by comparing the experimental results with the results of the two mainstream registration methods (the iterative closest point [ICP] registration method and the coherent point drift method). In the experiments, the comparison was based on the registration accuracy and the execution time. We show our registration method can obtain higher accuracy in a shorter time in most cases. At the same time, when using ICP to further refine our results, the ICP method can converge in a very short time, which also shows that our method provides a good initial pose for the ICP method and can help the ICP converge to the global optimal solution faster. Our method can achieve an average rotation error of 0.124 degrees and an average translation error of 0.38 mm on 10 clinical data.ConclusionsThe results reveal that the surface registration method based on translation rotation decoupling can achieve superior performance regarding both the registration accuracy and the time efficiency in the image‐to‐patient spatial registration.
Trendbericht Biochemie 2022: Strukturbiologie an der Schnittstelle zwischen Mensch und Mikrobe
Authors: Roderer Daniel 
Published: June 2022

AbstractÜber spezialisierte Enzyme, Affinitätsselektionsmethoden, um bioaktive Substanzen zu entdecken, hochauflösende Strukturanalyse von Proteinkomplexen und die Kombination von Bio‐ und Photokatalyse.
Improving Salmonid Monitoring by Nocturnal Counting in Rivers
Authors: Kambestad Marius , Hellen Bjart Are , Jensen Knut Helge Midtbø , Sægrov Harald 
Published: June 2022

Abstract
Accurate abundance estimates are crucial for evidence-based fisheries management. In rivers, drift dive counting and electrofishing are commonly used for quantifying fish abundance. However, the likelihood that fish are detected by these counting methods is affected by a range of factors, with substantial potential implications for the outcomes. Fish behavior and distribution also differs with light intensity, yet diel variation in abundance estimates produced by common enumeration methods has received little attention. Here, we present a comparison of diurnal and nocturnal counts of the landlocked population of Atlantic Salmon Salmo salar, known as “småblank,” and Brown Trout Salmo trutta in a Norwegian river. Six drift dive transects and 12 electrofishing sites were surveyed at day and night in early autumn. During drift dives, småblank were exclusively observed at night. Brown Trout were observed by snorkelers both day and night but in significantly higher numbers at night (six times more Brown Trout per 100 m at night versus in the day). Catch per unit effort of backpack electrofishing was significantly higher at night than at daytime for both småblank and Brown Trout older than age 0 (202% and 108% higher, respectively). We argue that differences in drift dive counts were mainly caused by fish hiding in the substrate during the day and being more active at night, resulting in diel differences in detection rate. Further studies are needed to determine whether differences in electrofishing catches were caused by diel fish migrations or higher catchability at night.
State estimation in nonlinear parametric time dependent systems using tensor train
Authors: Damiano Lombardi 
Published: June 2022

AbstractIn the present work, we propose a reduced‐order method to solve the state estimation problem when nonlinear parametric time‐dependent systems are at hand. The method is based on the approximation of the set of system solutions by means of a tensor train format. The particular structure of tensor train makes it possible to set up both a variational and a sequential method. Several numerical experiments are proposed to assess the behavior of the method.
Total Synthesis of Resveratrone andiso‐Resveratrone
Authors: Fritsch Stefan , Aldemir Nazli , Balszuweit Jan , Bojaryn Kevin , Voskuhl Jens , Hirschhäuser Christoph 
Published: June 2022

AbstractThe first total synthesis of resveratrone andiso‐resveratrone based on an epoxide olefination approach is described. The pivotal reaction proceeds by insertion of the lithiated epoxide into a boronic ester and subsequentsyn‐elimination. Resveratrone has been described to have remarkable photophysical properties, including two‐photon absorption. Therefore, an azide derivative has been prepared to allow for use as a biological label.
Thermal conductivity and compressive strength of silicone rubber composites enhanced by aligned carbon nanofiber scaffold
Authors: Zhan Chen , Cui Wenzhi , Li Longjian , Quan Xiaojun , Zhang Yuqi , Xu Yong , Xiao Fei , Li Weiping 
Published: June 2022

AbstractPolymer composites with high enough thermal conductivity, known as thermal interface materials (TIMs), are continuously pursued in the thermal management of high‐power density electronic and energy devices. In this article, to improve the heat transfer performance of TIMs, we constructed an aligned carbon nanofiber (CNFs) scaffold via the freeze‐casting method to serve as heat conduction paths in the TIMs. The composites of aligned CNF scaffold and silicone rubber were obtained by immersing the aligned scaffold into the silicone rubber with vacuum assist. We studied the influences of different CNFs diameters on the thermal conductivity of the composites, the pore sizes of the aligned CNF scaffold and the thermal conductivity of the composites fabricated under different freezing temperatures, and also the mechanical properties of the composites. Owing to the aligned scaffold, providing directional and continuous heat conduction paths, the thermal conductivity of the composites reached 3.17 W/(m·K) at 7.73 vol% CNFs. Additionally, the compressive strength and fracture strain of the composites were also greatly improved.
Quantitative structure–property relationship for the critical temperature of saturated monobasic ketones, aldehydes, and ethers with molecular descriptors
Authors: Huoyu Rao , Zhiqiang Zhu , Zhanggao Le , Zhenzhen Xu 
Published: June 2022

AbstractDensity functional theory calculations on saturated monobasic ketones, aldehydes, and ethers were carried out using Gaussian‐16 software. For each compound, the most stable molecule with the lowest energy and no imaginary frequency was found, and the molecular descriptors were calculated using the Alvadesc software based on the optimized geometry. The stepwise MLR method was used to develop a four‐parameter linear regression equation between the critical temperatures and molecular descriptors of 50 compounds in the training set, with a correlation coefficient of .9991. The QSPR model was robust and reliable, according to the Fisher and student‐t tests, the Durbin‐Watson test, cross‐validation and external validation, and application domain analysis.
Effect of lymphotoxin blockage on different stages of Sjogren's syndrome in an animal model
Authors: Jacob Alexander , Shen Long , He Jing , Nealon Kelly , Alexander Jessy J. , Ambrus Julian L. 
Published: June 2022

AbstractBackgroundLymphotoxin (LT) is an important mediator in Sjogren's syndrome (SS), both in patients and in animal models. Deletion of the LT alpha gene prevented the development of disease manifestations in the interelukin alpha transgenic mouse (IL14αTG) mouse model of SS.AimsThe current study was designed to evaluate the use of LT inhibitors at different stages of the disease in IL14αTG mice.Materials and MethodsIL14αTG mice were treated with anti‐LTa monoclonal antibody, LTb receptor‐immunoglobulin fusion protein (LTBR‐Ig) or isotype control during different stages of disease and analysis of salivary gland function, immunoglobulins, autoantibodies and histology of internal organs performed.Results and DiscussionThe inhibitors were very effective in maintaining salivary gland function and preventing infiltration of the glands with lymphocytes when used in the early stages of the disease. Blocking LT at later stages of the disease did not recover salivary gland function but was still effective in limiting extra glandular manifestations including eye disease and tumor development. Some differences were noted in the effectiveness of anti‐LTα versus LTBR‐Ig in limiting particular disease manifestations.ConclusionLT inhibitors deserve further investigation in the management of SS at whatever stage is identified.
Disturbance estimation for robotic systems using continuous integral sliding mode observer
Authors: Zhang Zengjie , Wollherr Dirk , Najjaran Homayoun 
Published: June 2022

AbstractThis article presents a novel force‐sensor‐less method for the estimation of external forces for a general class of second‐order robotic systems. The method is based on the integral sliding mode observer (ISMO) which serves as a second‐order differentiator for the position measurement of the system. As a result, the system states and disturbance are estimated without explicitly using force and velocity measurements. To apply the ISMO to the general second‐order systems, a proper assumption is proposed to address their nonlinearity and discontinuity. The boundary‐layer method is applied to ensure that the virtual inputs of the observer are continuous such that the chattering phenomenon is attenuated. A Lyapunov‐based method is used to analyze the influence of the boundary layers on the convergence of the state‐ and disturbance‐estimation errors. This influence, mainly determined by the boundary‐layer scalars, is given in analytical forms as a reference for parameter selection. The method is evaluated by numerical simulation on a robot manipulator system and compared with a conventional sliding mode observer (SMO). The validation of the performance of the continuous ISMO indicates its generalizability to general second‐order robotic systems. Also, the advantage of continuous ISMO over the conventional SMO is reflected by its small estimation errors and superior responsiveness. In general, the proposed method in this paper may interest those who are seeking solutions for haptic robotic tasks without using force sensors.
Polysaccharide‐Polyplex Nanofilm Coatings Enhance Nanoneedle‐Based Gene Delivery and Transfection Efficiency
Authors: Hachim Daniel , Zhao Juzhi , Bhankharia Jash , Nuñez‐Toldra Raquel , Brito Liliana , Seong Hyejeong , Becce Michele , Ouyang Liliang , Grigsby Christopher L. , Higgins Stuart G. , Terracciano Cesare M. , Stevens Molly M. 
Published: June 2022

AbstractNon‐viral vectors represent versatile and immunologically safer alternatives for nucleic acid delivery. Nanoneedles and high‐aspect ratio nanostructures are unconventional but interesting delivery systems, in which delivery is mediated by surface interactions. Herein, nanoneedles are synergistically combined with polysaccharide‐polyplex nanofilms and enhanced transfection efficiency is observed, compared to polyplexes in suspension. Different polyplex‐polyelectrolyte nanofilm combinations are assessed and it is found that transfection efficiency is enhanced when using polysaccharide‐based polyanions, rather than being only specific for hyaluronic acid, as suggested in earlier studies. Moreover, results show that enhanced transfection is not mediated by interactions with the CD44 receptor, previously hypothesized as a major mechanism mediating enhancement via hyaluronate. In cardiac tissue, nanoneedles are shown to increase the transfection efficiency of nanofilms compared to flat substrates; while in vitro, high transfection efficiencies are observed in nanostructures where cells present large interfacing areas with the substrate. The results of this study demonstrate that surface‐mediated transfection using this system is efficient and safe, requiring amounts of nucleic acid with an order of magnitude lower than standard culture transfection. These findings expand the spectrum of possible polyelectrolyte combinations that can be used for the development of suitable non‐viral vectors for exploration in further clinical trials.
Systematic analysis of software development in cloud computing perceptions
Authors: Khan Habib Ullah , Ali Farhad , Nazir Shah 
Published: June 2022

AbstractCloud computing is characterized as a shared computing and communication infrastructure. It encourages the efficient and effective developmental processes that are carried out in various organizations. Cloud computing offers both possibilities and solutions of problems for outsourcing and management of software developmental operations across distinct geography. Cloud computing is adopted by organizations and application developers for developing quality software. The cloud has the significant impact on utilizing the artificial complexity required in developing and designing quality software. Software developmental organization prefers cloud computing for outsourcing tasks because of its available and scalable nature. Cloud computing is the ideal choice utilized for development modern software as they have provided a completely new way of developing real‐time cost‐effective, efficient, and quality software. Tenants (providers, developers, and consumers) are provided with platforms, software services, and infrastructure based on pay per use phenomenon. Cloud‐based software services are becoming increasingly popular, as observed by their widespread use. Cloud computing approach has drawn the interest of researchers and business because of its ability to provide a flexible and resourceful platform for development and deployment. To determine a cohesive understanding of the analyzed problems and solutions to improve the quality of software, the existing literature resources on cloud‐based software development should be analyzed and synthesized systematically. Keyword strings were formulated for analyzing relevant research articles from journals, book chapters, and conference papers. The research articles published in (2011–2021) various scientific databases were extracted and analyzed for retrieval of relevant research articles. A total of 97 research publications are examined in this SLR and are evaluated to be appropriate studies in explaining and discussing the proposed topic. The major emphasis of the presented systematic literature review (SLR) is to identify the participating entities of cloud‐based software development, challenges associated with adopting cloud for software developmental processes, and its significance to software industries and developers. This SLR will assist organizations, designers, and developers to develop and deploy user‐friendly, efficient, effective, and real time software applications.
Dopamine‐transporter heterozygous rats carrying maternal wild‐type allele are more vulnerable to the development of compulsive behavior
Authors: Festucci Fabiana , Annunzi Eugenia , Pepe Martina , Curcio Giuseppe , D'Addario Claudio , Adriani Walter 
Published: June 2022

AbstractCompulsivity is defined as an unstoppable tendency toward repetitive and habitual actions, which are reiterated despite negative consequences. Polydipsia is induced preclinically by intermittent reward, leading rodents to ingest large amounts of fluids. We focused on the role of dopamine transporter (DAT) and inheritance factors in compulsive behavior. Our sample consisted of DAT heterozygous (HET) rats with different genetic inheritance (MAT‐HET, born from WT‐dams × KO‐fathers; MIX‐HET, born from HET‐dams × KO‐fathers). As controls, we used both wild‐type (WT) rats and their socially‐isolated (WTi) siblings. We ran the schedule‐induced polydipsia (SIP) protocol, to induce compulsive behavior; then the Y‐maze and marble‐burying tests, to verify its actual development. Only MAT‐HET (who inherited the functional DAT allele from the WT mother) is vulnerable to developing compulsive behavior. MAT‐HET rats drank increasingly more water during SIP; they showed significant perseverance in the Y‐maze test and exhibited compulsive actions in the marble‐burying test. Interestingly, compulsive behaviors of MAT‐HET rats correlated with expression ex vivo of different genes in different areas. Regarding the prefrontal cortex (PFC), D2R correlated with Y‐maze “perseverance” in addition to BDNF; considering the amygdala (AMY), both D3R and OXTR correlated with SIP “licks.” Indeed, compulsivity may be linked to D2R and BDNF in PFC, while extreme anxiety in MAT‐HET rats may be associated with D3R and OXTR in the AMY. These results confirm some similarities between MAT‐HET and DAT‐KO subjects, and link the epigenetic context of the DAT gene to the development of compulsive behavior.
Prosociality in an International Perspective: Civic Engagement and Volunteering
Authors: Gökce Habibe Erdiş , Sjö Sofia , Nynäs Peter , Lagerström Martin 
Published: June 2022

AbstractIn many studies of young adults, prosocial attitudes and behaviors are on the agenda. The often reported decline in civic engagement among young adults is generally presented as a concern. Prosocial attitudes and behaviors have been linked to aspects of well-being; high scores on some prosocial attitude indicators are seen as a sign of positive adjustment. Prosocial attitudes and behaviors are also key in discussions of civic engagement, volunteering, and altruism – aspects, in a sense, of the well-being of a society, and they are also of interest in discussions of religion. Commonly, a link between prosociality and religion has been indicated.In this chapter, we bring together findings from the research project Young Adults and Religion in Global Perspective (YARG) for an overview of prosocial attitudes and behaviors among young adult university students. We focus particularly on civic engagement and volunteering. Based on survey data, we first briefly explore who expresses prosocial attitudes and behaviors and the values connected to prosocial behaviors. This perspective offers only tentative answers. For a more in-depth view, we continue by exploring the data from the Faith Q-Sort. Finally, we zoom in on two examples, Turkey and Sweden, and compare the views on civic engagement and volunteering among young adults in these two contexts.