bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medium to long-term patterns of soil properties in forest restoration models in seasonally dry Atlantic Forest biome
Authors: Paula Ranieri Ribeiro 
Published: January 2022

Abstract

The medium- to long-term impacts of forest restoration models on soil properties are not well documented in the Atlantic Forest biome, especially in a seasonally dry climate. We assessed patterns of topsoil fertility, soil organic carbon (SOC) storage, and isotopic signatures of 13C in gradient with three areas with natural regeneration of native forest (NF) with 50 years of old, two areas with monocultures of N2-fixer and non-N2-fixer tree species, six years after planting on grass pasture, and one area with grass pasture in the last 40 years of age. In each area, three to nine composite soil samples were collected at 0-20 cm soil depth during the rainy season for analysis. The topsoil of the NF regenerated after coffee was the most depleted soil fertility and SOC storage in our vegetation gradient. The grass pasture and forest plantations showed smaller soil acidity and a larger base concentrations than the NF areas. The SOC storage was larger in NF after grass pasture and selective cutting, followed by grass pasture, with 80, 76, and 69 Mg ha-1, respectively. The planting of legume trees decreased SOC storage by approximately 35% during SOC storage, independent of N2-fixing capacity. The SOC derived from trees increased rapidly in the first six years of tree plantation (≈ 3 Mg SOC ha-1 year-1). The recovery of soil fertility and SOC storage by long-term natural regeneration differs according to historical land use. Differences in N2-fixation capacity had little effect on soil properties in the medium term.
A Numerical Study of Automotive Body Panel Draw Dies Defects Using Finite Element Simulation
Authors: Yadegari Farzad , Sehhat M. Hossein , Mahdianikhotbesara Ali 
Published: January 2022

Abstract
Among the advantages of the sheets used in the car body, it can mention the high strength, low thickness and suitable ductility. crack and wrinkling of the sheet are the most common types of defects in the drawing process. Therefore, it seems necessary to know the process factors that affect the sheet metal forming behavior. One of the critical tools of simulation and subsequent process optimization is the finite element method. In this research, with the help of AutoForm software, finite element simulation of the process is performed. After designing the appropriate Taguchi experiment, the parameters affecting the outputs, including thickness strain and surface strain on the production part, are investigated, and optimal values ​​are introduced. The known effective parameters on the process output include the forming limit diagram, sheet strength, friction coefficient, die balancers, and used sheet thickness.
Origin of Probability in Quantum Mechanics and the Physical Interpretation of the Wave Function
Authors: Wen Shuming 
Published: January 2022

Abstract
The theoretical results of quantum mechanics (QM) have been verified by experiments, but the probabilistic Copenhagen interpretation is still controversial, and many counterintuitive phenomena are still difficult to understand. To trace the origin of probability in QM, we construct the state function of a multiparticle quantum objective system and find that the probability in QM originates from the particle number distribution rate in a unit volume near position r at time t in the multiparticle quantum objective system. Based on the origin of probability, We find that the state function of an elementary particle (hereinafter called particle for short) has precise physical meaning; that is, the particle periodically and alternately exhibits the particle state and wave state in time and space, obtain the localized and nonlocalized spatiotemporal range of the particle, the apparent trajectory of the particle motion. Based on this, through rigorous mathematical derivation and analysis, we propose new physical interpretations of the quantum superposition state, wave-particle duality, the double-slit experiment, the Heisenberg uncertainty principle, and the quantum tunnelling effect, and these interpretations are physically logical and not counterintuitive.
Dendronized Porphyrins: Molecular Design and Synthesis
Authors: Vonlanthen Mireille , Cuétara-Guadarrama Fabián , Porcu Pasquale , Sorroza-Martínez Kendra , González-Méndez Israel , Rivera Ernesto 
Published: January 2022

Abstract:In this review, we report different methods and strategies to synthesize flexible and rigid dendronized porphyrins. We will focus on porphyrin dendrimers that have been reported in the last 10 years. Particularly, in our research group, we have designed and synthesized different series of dendronized porphyrins (free base and metallated) with pyrene units at the periphery and Fréchet-type dendritic arms. The Lindsey methodology has allowed the synthesis of meso-substituted porphyrins with various substitution patterns, such as symmetric, dissymmetric, or unsymmetric. Porphyrin dendrimers have been prepared by different synthetic methodologies; one of the most reported being the convergent method, where the dendrons are first prepared and further linked to a meso-substituted functionalized porphyrin unit, which will constitute the core of the dendrimer. Another interesting synthetic approach is the use of a reactive dendron bearing a terminal aldehyde functional group to form the final porphyrin core. In this way, a two-armed dendronized dissymmetric porphyrin core can be prepared from a dendritic precursor and a dipyrromethene derivative. This strategy is very convenient to prepare low-generation dendritic porphyrins. The divergent approach is another well-known methodology for porphyrin dendrimer synthesis, mostly used for achieving highgeneration dendrimers. Click chemistry reaction has been advantageous for the development of more complex porphyrin dendritic structures. This reaction presents important advantages, such as high yields and mild reaction conditions, which permit the assembly of different multiporphyrin dendritic structures. In the constructs presented in this review, the emission of the porphyrin moiety has been observed, leading to potential applications in artificial photosynthesis, sensing, nanomedicine, and biological sciences.
Scientific and Technological Prospecting of 1H-1,2,3-Triazoles
Authors: Caiana Rodrigo Ribeiro Alves , Santos Cosme Silva , de Oliveira Ronaldo Nascimento , Freitas Juliano Carlo Rufino 
Published: January 2022

Abstract:
The use of 1H-1,2,3-triazoles has become an important scaffold for applications in
different technological sectors. Therefore, we sought to carry out technological monitoring to
understand the international scenario involving 1H-1,2,3-triazoles from the patents filed, in
addition to evaluating the relationship between the growth in the number of patents and the
improvement of strategies for obtaining these compounds via a metal-catalyzed azide-alkyne
cycloaddition reaction. Technological monitoring was performed with the support of the PatentInspiration
® platform, using the keywords "1,2,3-triazol", "1,2,3-triazole", and "1,2,3-
triazolyl". A total of 960 registered patents were found, most for the years 2014 and 2019. The
main filers were prestigious multinational companies, such as Syngenta, Merck, Sandoz,
Pfizer, and Bayer. The United States, China, Japan, and Germany lead patent registrations,
mainly addressing innovations in chemistry and metallurgy, human needs, and new technologies. These results help
to understand the state of innovation for this topic, pointing out the characteristics of the main discoveries concerning
1H-1,2,3-triazole derivatives.
Synergy based Extracts of Medicinal Plants: Future Antimicrobials to Combat
Multidrug Resistance
Authors: Husain Syed Akhtar , Ahmad Sayeed , Abass Sageer , Parveen Rabea , Irfan Mohammad , Jan Bisma 
Published: January 2022

Abstract:
The use of herbal medicines and supplements in the last thirty years has increased enormously. Herbal medication has demonstrated promising and effective potential against vari-ous diseases. Herbal and phytoconstituent medications are gaining popularity globally and many people are adopting herbal remedies to deal with different health issues. The indiscriminate use of antibiotics, due to the development of antimicrobial resistance, poses an unprecedented prob-lem for human civilization. Bacterial infections are difficult to cure because of the propensity of microbes to acquire resistance to a wide range of antimicrobial drugs. New compounds are being explored and quantified for possible antibacterial activity with little or no side effects. Research-ers are investigating the range of therapeutic plants mentioned in Unani, Ayurveda, and Siddha around the globe. Known and commonly acclaimed global databases such as PubMed, Research Gate, Science Direct, Google Scholar were searched using different search strings such as Indian medicinal plants, multidrug resistance (MDR), thin layer chromatography (TLC), antimicrobials, and Synergism were used in diverse combinations to reclaim numerous citations associated with this area. Thus, the current review aims to shed a light on the information of medicinal plants as a potential foundation of herbal drugs and elucidate how synergism and TLC bioautography play a crucial role in finding antimicrobial compounds.
Developing 3D Technology for Drug Discovery
Authors: Hosseinkhani Hossein 
Published: January 2022

Abstract:
Developing 3D living systems will open many doors and lead to significant improve-ments in biological tools, drug discovery process, lead identification as well as therapeutic ap-proaches. The miniaturization of this approach allows one to perform many more experiments than previously possible more simply. 3D in vitro technology aims to develop a set of tools that are simple, inexpensive, portable, and robust that could be commercialized and used in various fields of biomedical sciences, such as drug discovery, diagnostic tools, therapeutic approaches, and regenerative medicine.
Nanotechnology-based Medicinal Products and Patents: A Promising Way
to Treat Psoriasis
Authors: Ali Faraat , Neha Kumari , Sharma Kamna , Khasimbi Shaik , Chauhan Garima 
Published: January 2022

Abstract:
Psoriasis is an autoimmune skin disorder that is characterised by chronic inflammation and
erythematous scaly patches. It has a significant impact on the patient's quality of life and can cause psychological
stress. There are several aspects that cause psoriasis, for instance, environmental issues, immune
disorders, bacterial infections, and genetic issues. Plentiful therapeutic means or treatments are
accessible, but not any of them can completely and effectively cure psoriasis without hindering patient
compliance. Hence, it becomes challenging to discover a new drug moiety or any drug delivery method
to cure psoriasis. Conventional treatment of psoriasis involves anti-inflammatory agents, immune suppressants,
phototherapy, and biological treatment, which were given in different forms such as topical,
oral, or systemic formulations, but these all were unsuccessful to accomplish complete reduction of
psoriasis as well as causing adverse side effects. In terms of dose frequency, doses, efficacy, and side
effects, nanotechnology-based new formulations are the most promising prospects for addressing the
challenges and limits associated with present psoriasis formulations. Hence, our major goal of this review
is to present various advanced nanotechnological approaches for the effective topical treatment of
psoriasis. In short, nano-formulations continue to be formed as very promising modalities in the treatment
of psoriasis as they suggest improved penetration, targeted delivery, increased safety, and efficacy.
Cardiovascular Risk Prediction Equations Underestimate Risk in People
Living with HIV: Comparison and Cut-point Redefinition for 19 Cardiovascular
Risk Equations
Authors: Grand Marina , Díaz Alejandro , Bia Daniel 
Published: January 2022

Background:
Rates of cardiovascular disease are higher in people living with HIV. Early
detection of high-risk subjects (applying cardiovascular risk equations) would allow preventive
actions. D:A:D, ASCVD, and FRS:CVD equations are the most recommended. However, controversies
surround these equations and cut-points, which have the greatest capacity to discriminate
high-risk subjects.

Objectives:
The study aims (i) to assess the association/agreement between cardiovascular risk levels
obtained with D:A:D and fifteen other cardiovascular risk equations, (ii) to detect cardiovascular
risk equation’s capability to detect high-risk subjects, and (iii) to specify the optimal cardiovascular
risk equation´s cut points for the prediction of carotid plaque presence, as a surrogate of high
cardiovascular risk.

Methods:
86 adults with HIV were submitted to the clinical, laboratory, and cardiovascular risk
evaluation (including carotid ultrasound measurements). Cardiovascular risk was evaluated
through multiple risk equations (e.g., D.A.D, ASCVD, and FRS equations). Association and agreement
between equations (Correlation, Bland-Altman, Williams´test) and equation’s capacity to detect
plaque presence (ROC curves, sensitivity, specificity) were evaluated.

Results:
Cardiovascular risk equations showed a significant and positive correlation with plaque
presence. Higher high-cardiovascular risk detection capability was obtained for ASCVD and
D:A:D. Full D:A:D5y>0.88 %, ASCVD>2.80 %, and FRS:CVD>2.77 % correspond to 80 % sensitivity.

Conclusion:
All cardiovascular risk equations underestimate the true risk in HIV subjects. The cut--
points for high cardiovascular risk were found to vary greatly from recommended in clinical guidelines.
Efficient Fluorescent Detection of Mercuric Ions Based on 2-Thienyl
benzimidazole/Cucurbit[7]uril Complexes
Authors: Al-Handawi Marieh B. , Graham John P. , Eldeab Hany A. , Saleh Na'il 
Published: January 2022

Aim:
2-Thienylbenzimidazole (TBI)/cucurbit[7]uril (CB7) host/guest
complex was used to significantly improve the detection of Hg2+ in water samples.

Methods:
The unique mechanism of the sensing process is based on the binding of CB7 host to TBI
guest. The host-guest complexation was confirmed by UV-visible absorption, time-resolved fluorescence,
and proton NMR spectroscopy. The complexations of TBI and TBI/CB7 with Hg2+ ions in
solid-state were confirmed by FTIR, mass, and TGA. The most stable structures were unfolded by
DFT calculations.

Results:
In an aqueous solution, a five-fold higher stability constant of the protonated TBIH+/CB7
complex was observed when compared to the neutral TBI/CB7 complex as manifested in an increase
in pKa values by ~ 0.5 unit in an excited state. The static fluorescence quenching of TBI on
binding to Hg2+ ions was significantly enhanced in the presence of CB7.

Conclusion:
Macrocycles are useful additives for the highly sensitive recovery of mercury ions in
water samples.
Molecular Docking and Dynamics Simulation Studies of a Dataset of NLRP3
Inflammasome Inhibitors
Authors: dos Santos Nascimento Igor J. , de Aquino Thiago M. , da Silva-Júnior Edeildo F. 
Published: January 2022

Background:
The organism’s defense against aggressive agents is performed by the innate
immune system via activation of pattern-recognition receptors (PRRs). Initially, these agents
are recognized by the immune system, resulting in the inflammatory response that activates the
pathogen elimination and tissue repair. Inflammasomes are macromolecules related to the host’s response
to endo or exogenous aggressive agents. Thus, inflammation mediated by inflammasomes
plays an important role in the pathogenesis of diseases, such as neurodegenerative disorders, autoimmune
diseases, and type 2 diabetes, justifying their attractiveness as drug targets. One of the
most important tasks remains in the ATPase nucleotide-binding oligomerization domain nucleotide-
binding domain leucine-rich repeat-containing receptors protein 3 (NLRP3), in which the
blocking of its oligomerization is related to the functional inhibition of inflammasomes. Here, we
performed molecular docking and dynamics simulations for NP3-146, an analog of MCC950, to obtain
information about the complex stability and main interactions with amino acid residues from
NLRP3.

Methods:
By using the crystalized structure recently deposited in the protein data bank (7alv),
molecular docking in GOLD software and molecular dynamics simulations in GROMACS software
were performed to generate the RMSD RMSF, Rg, SASA, and H-bond plots.

Results:
The results of RMSD, RMSF, Rg, SASA, and H-bond plots of both complexes confirmed
the stability at the active site. Besides, the analyses of the most stable conformation showed that
the main interactions are performed with Ala227, Ala228, Pro352, Ile411, Phe575, and Arg578 residues.

Conclusion:
This report confirmed the stability of NP3-146, similar to the known inhibitor MCC950,
providing useful information for designing NLRP3 inhibitors.
Web Portals for Patients With Chronic Diseases: Scoping Review of the Functional Features and Theoretical Frameworks of Telerehabilitation Platforms
Authors: Morimoto Yuh , Takahashi Tetsuya , Sawa Ryuichi , Saitoh Masakazu , Morisawa Tomoyuki , Kagiyama Nobuyuki , Kasai Takatoshi , Dinesen Birthe , Hollingdal Malene , Refsgaard Jens , Daida Hiroyuki 
Published: January 2022

Background
The COVID-19 pandemic has required an increased need for rehabilitation activities applicable to patients with chronic diseases. Telerehabilitation has several advantages, including reducing clinic visits by patients vulnerable to infectious diseases. Digital platforms are often used to assist rehabilitation services for patients in remote settings. Although web portals for medical use have existed for years, the technology in telerehabilitation remains a novel method.

Objective
This scoping review investigated the functional features and theoretical approaches of web portals developed for telerehabilitation in patients with chronic diseases.

Methods
PubMed and Web of Science were reviewed to identify articles associated with telerehabilitation. Of the 477 nonduplicate articles reviewed, 35 involving 14 portals were retrieved for the scoping review. The functional features, targeted diseases, and theoretical approaches of these portals were studied.

Results
The 14 portals targeted patients with chronic obstructive pulmonary disease, cardiovascular, osteoarthritis, multiple sclerosis, cystic fibrosis diseases, and stroke and breast cancer survivors. Monitoring/data tracking and communication functions were the most common, followed by exercise instructions and diary/self-report features. Several theoretical approaches, behavior change techniques, and motivational techniques were found to be utilized.

Conclusions
The web portals could unify and display multiple types of data and effectively provide various types of information. Asynchronous correspondence was more favorable than synchronous, real-time interactions. Data acquisition often required assistance from other digital tools. Various functions with patient-centered principles, behavior change strategies, and motivational techniques were observed for better support shifting to a healthier lifestyle. These findings suggested that web portals for telerehabilitation not only provided entrance into rehabilitation programs but also reinforced participant-centered treatment, adherence to rehabilitation, and lifestyle changes over time.
Клінічні результати одновиросткового ендопротезування колінного суглоба при медіальному остеоартрозі
Authors: Bilonozhkin G.G. 
Published: January 2022

У роботі наведені результати одновиросткового ендопротезування при медіальному остеоартрозі колінного суглоба у 48 пацієнтів (54 суглоба), середній вік — 64 роки. Оперативні втручання виконувались з використанням імплантатів Oxford (фаза 3). При вивченні результатів до 5 років після операції відмінні результати за шкалою Міжнародної асоціації колінного суглоба отримані в 69,2 % випадків, хороші — у 30,8 %. З урахуванням суворих показань до операції одновиросткового ендопротезування колінного суглоба її малоінвазивна техніка є органозберігаючою, скорочує терміни реабілітації пацієнтів, дозволяє досягти сприятливих функціональних результатів.
Діагностика й лікування хворих із травматичними ушкодженнями периферичних нервів в умовах бойових дій
Authors: Tsymbaliuk V.I. , Luzan B.N. , Tsymbaliuk I.V. 
Published: January 2022

Зважаючи на наявність збройного конфлікту на Сході України, розв’язання проблеми ефективного та адекватного надання допомоги пораненим із вогнепальними ушкодженнями периферичних нервів є актуальним та необхідним.За останній період нами проліковано 88 пацієнтів із вогнепальними ушкодженнями периферичних нервів. Вік пацієнтів становив від 21 до 54 років, середній вік — 31 рік. Хворі надходили для спеціалізованого лікування в термін від 1 до 6 місяців. Ушкодження сідничного нерва спостерігалося у 26,15 % випадків, ліктьового — у 20,45 %, серединного — у 19,32 %, променевого — у 14,77 %, великогомілкового — в 11,36 %, малогомілкового — у 7,95 % випадків. Ступінь відновлення рухів оцінювали за шкалою від M0 до M5, чутливості — від S0 до S5. Проводилося електронейроміографічне дослідження для визначення функціонального стану уражених нервів.Залежно від ушкодження нервів проводився невроліз (72,73 % випадків, у тому числі в поєднанні з імплантацією електростимуляційних систем), шов нерва (19,32 %), а у випадку великих дефектів — автопластика литковим нервом (7,95 %). Ступінь відновлення рухової функції до M0–M2 спостерігався у 39,77 % пацієнтів, до M3 — у 32,95 %, до M4 — у 18,18 %, до M5 — у 9,1 %. Ступінь відновлення чутливості до S0–S2 зареєстрований у 36,37 %, до S3 — у 39,77 %, до S4 — у 18,18 %, до S5 — у 5,68 %. Після хірургічного лікування регрес больового синдрому спостерігався у 89,77 % випадків.Будо зроблено висновки, що:— оперативні втручання при вогнепальних ушкодженнях периферичних нервів повинні проводитися в спеціалізованих закладах;— результати хірургічного лікування вогнепальних уражень периферичної нервової системи в цілому гірші, ніж інших видів ушкоджень;— імплантація електростимуляційних систем покращує результати лікування вогнепальних уражень периферичних нервів.
Лікування остеопорозу у людей старшого віку після первинного ендопротезування кульшового суглоба
Authors: Shimon V.M. , Lytvak V.V. , Sheregiy A.A. 
Published: January 2022

На сьогодні одним із найактуальніших питань у травматології і ортопедії є відновлення функцій руху в суглобах і опорності кінцівок. Лікування переломів шийки стегна, особливо у людей літнього віку, вимагає додаткових витрат, як матеріальних, так і моральних. Питання хірургічного лікування хворих літнього віку в даний час не викликає дискусій. Звідси висновок: лікування переломів шийки стегна у хворих похилого віку — це ендопротезування. Воно ефективне й доступне для хворого, який у найкоротші строки стає працездатним.