bluuebunny/crossref_metadata_2025_split huggingface dataset:
A think-aloud study of the feasibility of patients with end-stage organ failure completing the ICECAP-SCM
Authors: Nwankwo Henry , Coast Joanna , Hewison Alistair , Kinghorn Philip , Madathil Shyam , Bailey Cara 
Published: September 2022

Background: The ICECAP-Supportive Care Measure (SCM) is a self-complete measure developed to inform economic decision making at the end-of-life. Previous research has demonstrated its feasibility in hospice and nursing home settings. This is the first study of its use with patients on the organ failure trajectory. Aim: To determine the feasibility of using the ICECAP-SCM with patients experiencing end-stage organ failure in a hospital setting. Design: Participants were asked to ‘think aloud’ when completing the ICECAP-SCM, ICECAP-A and EQ-5D-5L measures. The interviews were transcribed verbatim and examined for errors in comprehension, retrieval, judgement, and response by five raters. Qualitative data were collected to explore reasons for errors in completing the measures and participants’ views about the measures. Setting/participants: Sixty patients (with end-stage renal failure n = 18; end-stage heart failure n = 21; end-stage chronic obstructive pulmonary disease n = 21) participated. Senior clinicians applied prognostic criteria to determine eligibility. Results: Participants reported that the measures were acceptable, clear, and easy to complete. Error rates in completing the measures were low (ICECAP-A = 3%,and ICECAP-SCM = 5.7% and EQ-5D-5L = 6.3%). There was some variation in responses between patients with different end-stage conditions, particularly those with symptom fluctuation. Some patients had not considered their end-of-life (i.e. advance care planning) and reported finding questions about this difficult to answer. Conclusion: It is feasible to use the ICECAP-SCM with patients with end-stage organ failure receiving care in hospital settings. This study provides evidence for researchers and policy makers involved in measuring end-of-life care globally. The ICECAP-SCM can be recommended for research with patients in end-stage organ failure to appropriately capture the broader benefits of end-of-life care.
Establishment of 6 pediatric rhabdomyosarcoma patient’s derived xenograft models closely recapitulating patients’ tumor characteristics
Authors: Gasparini Patrizia , Casanova Michela , Centonze Giovanni , Borzi Cristina , Bergamaschi Luca , Collini Paola , Testi Adele , Chiaravalli Stefano , Massimino Maura , Sozzi Gabriella , Ferrari Andrea , Moro Massimo 
Published: September 2022

Introduction: The prognosis for patients with metastatic and recurrent pediatric rhabdomyosarcoma (RMS) remains poor. The availability of preclinical models is essential to identify promising treatments We established a series of pediatric RMS patient derived xenografts (PDXs), all faithfully mirroring primary tumor characteristics and representing a unique tool for clarifying the biological processes underlying RMS progression and relapse. Methods: Fresh tumor samples from 12 RMS patients were implanted subcutaneously in both flanks of immunocompromised mice. PDXs were considered as grafted after accomplishing three passages in mice. Characterization of tumor tissues and models was performed by comparing both morphology and immunoistochemical and fluorescence in situ hybridization (FISH) characteristics. Results: Six PDXs were established, with a successful take rate of 50%. All models closely mirrored parental tumor characteristics. An increased grafting rate for tumors derived from patients with worse outcome (p = 0.006) was detected. For 50% PDXs grafting occurred when the corresponding patient was still alive. Conclusion: Our findings increase the number of available RMS PDX models and strengthen the role of PDXs as useful preclinical tools for patients with unmet medical needs and to develop personalized therapies.
Shall Children Play? Evidence from Arts in Late Imperial China
Authors: Ping-chen Hsiung 
Published: September 2022

AbstractThis article examines various positions on whether children should be allowed to play in late imperial China. Demonstrating distinctly different views from Neo-Confucian thinkers, professional genre painters of “Children at Play” (yingxi tu 嬰戲圖), and the emerging pediatric specialists, the article maintains that clearly multi-vocal forces coexisted during the Song Dynasty, including a persuasive child-favoring stance that remains unique in global humanities on this issue.
Personality development in immigrant and non-immigrant adolescents: Disruption or maturation?
Authors: Gillespie Sarah , Shiner Rebecca , Masten Ann S. , Motti-Stefanidi Frosso 
Published: September 2022

This study examined gender and immigrant status differences in stability and change in the Big Five traits in a sample of early adolescents in Greece from economically disadvantaged schools with a high immigrant composition (65% first- or second-generation immigrants). Youth in the sample ( N = 1252, 46% female, ages 12–13 at time 1) self-reported Big Five traits annually for 3 years. Mean-level and rank-order stability were examined separately by gender and immigration history. Growth modeling of mean-level scores showed declines in all five personality traits for both genders between ages 12 and 14, followed by increases in conscientiousness for girls and boys, and increases in agreeableness and openness to experience for boys only. In sensitivity analyses, boys showed disruption at all levels of perceived economic stress, but only girls with high levels of perceived economic stress showed disruption. Trajectories were similar for immigrant and non-immigrant youth, suggesting that immigrant youth did not show greater mean-level disruption. However, immigrant youth reported lower means on all traits except emotional stability. Rank-order stability was moderately strong over 3 years and comparable across both genders and immigration histories. Results in this high-risk sample supported the disruption hypothesis and suggest that immigration experiences are associated with personality development.
Mechanical properties of calcium phosphate reinforced polyhydroxyalkanoate (PHA) biocomposite
Authors: Najah MI , Aisyah R , Adzila S , Haq RHA 
Published: September 2022

In the area of bone tissue engineering, the concept of using biomaterials based bone scaffolds in the regeneration of critical size bone defects is a key element to development of alternatives to allogenic and autogolous bone graft. Globally, countries all over the world is experiencing population aging besides other bone defects related case including trauma, pathology and congenital defects. Calcium phosphate (CaP) has received much interest for broad range of bone substitutes since its physicochemical properties can be conveniently tailored with close resemblance to human bone constituents. In this study the mechanical properties of Polyhydroxyalakanoate (PHA)/CaP composite were investigated. CaP was reinforced in PHA in the range from 5 wt% to 30 wt% and the tensile and impact properties of the composite were investigated. The addition of CaP showed fluctuation value in both tensile strength and impact strength starting with drop at approximately three times lower than neat PHA. The maximum tensile stress recorded at 15 wt% of CaP was 7.93 MPa along with elastic modulus of 102.416 MPa while the minimum tensile stress recorded at 30 wt% of CaP was 2.423 MPa with elastic modulus of 49.455 MPa. In parallel, the highest impact strength showed at 15 wt% of CaP was 5.761 kJ/m2 while the lowest mechanical strength recorded at 30 wt% of CaP content. Morphological analysis demonstrates the crack surface of each sample with CaP inclusion in supporting the development of brittleness in nature of biocomposite throughout the inclusion of CaP osteo-filler. Admittedly, the finding of this study will contribute to development of PHA based scaffolds for bone tissue with compromise mechanical properties along with their biological performance identical or similar to that of an ancient graft or transplant upon implantation.
Transmissibility response analysis of a human body in semi-supine posture exposed to low-frequency vibrations
Authors: Govindan Rajesh , Saran V Huzur , Harsha Suraj Prakash 
Published: September 2022

The study presents transmissibility responses of 14 male subjects exposed to vertical sinusoidal vibration (2.0–16.0 Hz) at five vibration magnitudes (0.5–1.5 m s−2 r.m.s.). The vibration magnitudes are measured at five body locations: head (at the forehead), sternum, abdomen, thigh, and leg, for which the transmissibility at each body location is statistically analyzed. The nonlinearity in the transmissibility response, that is, decrease in resonance frequency with an increase in vibration magnitude, is evident for the sternum, abdomen, thigh, and leg. The higher vibration magnitude causes greater segmental transmissibility at excitation frequency lower than the resonance frequency. The highest vibration transmissibility has been observed for the abdomen, followed by the thigh, sternum, and head. The findings indicate that the higher energy content associated with the sinusoidal waveform further softens the tissues in contact with the vibrating surface. Practitioner Summary: The present study provides transmissibility responses of the semi-supine posture of humans at the head, sternum, abdomen, thigh, and leg under vertical sinusoidal excitation (2.0–16.0 Hz). Pronounced transmissibility is obtained for the abdomen among the other body segments, followed by the thigh, as both consist of a majority of soft tissues.
Awareness of HIV pre-exposure prophylaxis among men who have sex with men using apps for sexual encounters in Turkiye
Authors: Nazli Arzu , Garner Alex , Gokengin Deniz 
Published: September 2022

Background New HIV diagnoses are rising in Turkiye. Men who have sex with men (MSM) are estimated to be the main driver of the epidemic. Pre-exposure prophylaxis (PrEP) was proven to be effective in reducing new HIV diagnoses and PrEP recently became available in Turkiye. Objective To assess awareness of and willingness to use PrEP and the level of off-licence use among MSM. Methods An anonymous self-completed questionnaire was sent out over the Hornet Gay Social Network from December 2019 to February 2020, available in Turkish and Arabic. It included 20 questions on HIV and STI testing, PrEP awareness, PrEP use, willingness to use, chemsex and sexual happiness level. Results Overall 4761 respondents who responded to more than 1/3 of the questions were eligible for analyses; 5.5% was Arabic speaking. The mean age was 30.5 years, 31.4% had never tested for HIV, 40.5% knew what PrEP was, the most common source of knowledge was the internet (44.5%), 2.5% (120) had used PrEP in the last 12 months and 1.7% (83) was current users. PrEP users had accessed drugs over the internet (47.6%), pharmacy (23%), and friends (13.8%). Almost 40% were willing to use PrEP in the following 6 months. Younger and Arabic speaking respondents had lower rates of HIV testing ( p = .001) and lower awareness for PrEP than comparators ( p = .004). Conclusion Awareness and willingness to use PrEP is high among MSM in Turkiye. The recent availability of PrEP in the country is a big step forward in terms of prevention.
Depression, anxiety, and sleep quality in childhood onset systemic lupus erythematosus and relationship with brain-derived neurotrophic factor
Authors: Baba Ozge , Kisaoglu Hakan , Bilginer Cilem , Ozkaya Esra , Kalyoncu Mukaddes 
Published: September 2022

Background The association between brain-derived neurotrophic factor (BDNF) and systemic lupus erythematosus (SLE) is controversial, and no study investigated the clinical associations of BDNF in patients with childhood onset systemic lupus erythematosus (cSLE). In this study, we aimed to investigate the serum levels of BDNF in patients with cSLE and examine whether a relationship of BDNF exists among depression, anxiety, and sleep quality. Methods Thirty patients and age-sex matched healthy controls were included. Depression, anxiety, sleep quality and quality of life were assessed by relevant questionnaires. Disease activity was assessed according to the SLE disease activity index (SLEDAI) and serum BDNF level was measured by the enzyme-linked immunosorbent assay method. Results Serum BDNF level was significantly lower in cSLE patients than healthy controls (21981 vs 29905 pg/mL, p = 0.001) and significantly decreased level was observed in active cSLE (SLEDAI >0), then those with SLEDAI = 0 (17110 vs 26852 pg/mL, p = 0.005). Although the scores of the depression, anxiety, sleep quality and quality of life questionnaires were strongly correlated with each other, no correlation was observed with serum BDNF levels. Conclusions In patients with cSLE, serum level of BDNF was significantly decreased compared to healthy controls. Our results suggest that serum BDNF levels were not associated with the presence of anxiety, depression and poor sleep quality and might be dictated by the pathophysiological process of SLE rather than mood disorders.
Surge detection of magnetic suspension fluid machinery based on rotor axial displacement signal and normalized second-order generalized integrator-frequency locked loop with prefilter
Authors: Guan Xudong , Zhou Jin , Jin Chaowu , Lin Yingzhe 
Published: September 2022

A surge detection method according to rotor axial displacement signal and normalized second-order generalized integrator-frequency locked loop with prefilter (SOGI-FLL-WPF) is proposed to solve the surge detection problem of magnetic suspension fluid machinery, which has important practical significance. To improve the anti-disturbance performance of surge detection, SOGI is introduced as a prefilter. As a prefilter, SOGI can eliminate the interference in the surge signal, and normalized SOGI-FLL can estimate the amplitude and frequency of the surge signal. Normalized SOGI-FLL and prefilter are combined to form normalized SOGI-FLL-WPF. First, the disturbance transfer model between rotor axial displacement signal and pressure signal is deduced. Then, the surge is detected by normalized SOGI-FLL-WPF. This method has the merit of fast response, small computation, and good disturbance resistance without additional detection units. Finally, the test is implemented on 105 kW and 150 kW magnetic suspension blowers. The results demonstrate that the proposed method can quickly detect surge signal after the surge occurs.
Diffuse large b-cell lymphoma of the ocular adnexa with flow cytometry analysis and review of the literature
Authors: Mitamura Mizuho , Kase Satoru , Suzuki Yasuo , Sakaguchi Takatoshi , Suimon Yuka , Sinohara Toshiya , Shimizu AI , Matsuno Yoshihiro , Sakai Hajime , Kase Manabu , Ishida Susumu 
Published: September 2022

Purpose The aim of this study was to evaluate the clinicopathological features and flow cytometry (FCM) of tumor tissues in ocular adnexal diffuse large B-cell lymphoma (DLBCL). Methods This retrospective, multicenter case study was designed to evaluate the clinical and immunohistochemical features of tumors. DLBCL was diagnosed based on histopathology, immunoglobulin (Ig) heavy chain gene rearrangement, and FCM in all surgically removed periocular tumor tissues. This study involved assessing percentages (%) of B-cell/T-cell markers, a natural killer cell marker, and cell-surface Ig kappa/lambda (κ/λ) expression measured by FCM analysis in tumor tissues. Results Eleven DLBCL patients (4 men and 7 women) with 11 tumors were enrolled in this study. The median age at the time of initial presentation was 73 years. The tumor cells were immunohistochemically positive for cluster of differentiation (CD) 20, while CD5 was negative in all 8 cases tested. At the time of ophthalmic diagnosis, two cases already showed systemic dissemination of DLBCL throughout the body. FCM of tumor tissues detected a high percentage of B-cell markers including CD19 and CD20 in all 11 tumors. One case with high CD10 levels in FCM was histologic transformation from follicular lymphoma. One case with a relatively low CD20 population involved a history of systemic treatments including intravenous rituximab. Conclusion Although caution should be exercised when interpreting the data, FCM is useful for not only supportive diagnosis complementary to immunohistochemistry, but also facilitates a better understanding of immunopathology including histologic transformation of follicular lymphoma to DLBCL in the ocular adnexa.
Impact of the Patency of Inferior Mesenteric Artery on 7-Year Outcomes After Endovascular Aneurysm Repair
Authors: Ide Toru , Shimamura Kazuo , Kuratani Toru , Shijo Takayuki , Sakaniwa Ryoto , Watanabe Yoshiki , Maeda Koichi , Masada Kenta , Yamashita Kizuku , Matsumoto Ryota , Miyagawa Shigeru 
Published: September 2022

Purpose: The impact of preoperative patent inferior mesenteric artery (IMA) on late outcomes following endovascular aneurysm repair (EVAR) remains unclear. This study aimed to investigate the specific influence of IMA patency on 7-year outcomes after EVAR. Materials and Methods: In this retrospective cohort study, 556 EVARs performed for true abdominal aortic aneurysm cases between January 2006 and December 2019 at our institution were reviewed. Endovascular aneurysm repairs performed using a commercially available device with no type I or type III endoleak (EL) during follow-up and with follow-up ≥12 months were included. A total of 336 patients were enrolled in this study. The cohort was divided into the patent IMA group and the occluded IMA group according to preoperative IMA status. The late outcomes, including aneurysm sac enlargement, reintervention, and mortality rates, were compared between both groups using propensity-score-matched data. Results: After propensity score matching, 86 patients were included in each group. The median follow-up period was 56 months (interquartile range: 32–94 months). The incidence of type II EL at discharge was 50% in the patent IMA group and 19% in the occluded IMA group (p<0.001). The type II EL from IMA and lumbar arteries was significantly higher in the patent IMA group than in the occluded IMA group (p<0.001 and p=0.002). The rate of freedom from aneurysm sac enlargement with type II EL was significantly higher in the occluded IMA group than in the patent IMA group (94% vs 69% at 7 years; p<0.001). The rate of freedom from reintervention was significantly higher in the occluded IMA group than in the patent IMA group (90% vs 74% at 7 years; p=0.007). Abdominal aortic aneurysm–related death and all-cause mortality did not significantly differ between groups (p=0.32 and p=0.34). Conclusions: Inferior mesenteric artery patency could affect late reintervention and aneurysm sac enlargement but did not have a significant impact on mortality. Preoperative assessment and embolization of IMA might be an important factor for improvement in late EVAR outcomes. Clinical Impact The preoperative patency of the inferior mesenteric artery was significantly associated with a higher incidence of sac enlargement and reintervention with type II endoleak following endovascular aneurysm repair, even after adjustment for patient background. Preoperative assessment and embolization of inferior mesenteric artery might be an important factor for improvement in late EVAR outcomes.
Endovascular repair of an intrathoracic subclavian artery aneurysm with a single-branched thoracic endograft in a hostile anatomy
Authors: Bonvini Stefano , Spadoni Nicola , Tasselli Sebastiano 
Published: September 2022

Objective Subclavian artery aneurysms (SAA) are rare and usually involve the proximal segment of the artery. In this setting traditional surgical treatment or hybrid procedures are associated with significative morbidity rate so that new endovascular solutions are preferred. Methods Authors report a case of a patient with an intrathoracic left SAA involving the aortic arch’s outer curve. Patient’s comorbidities contraindicated open surgical treatment while anatomical issues were not favourable to hybrid or standard endovascular solutions. Thus a single-branched custom-made thoracic stent-graft (Castor, MicroPort Medical, Shanghai, China) was implanted. Results Technical success was achieved with no intra-operative complications and technical steps of the procedure are accurately described. A pre-discharge CT scan showed the correct position of the endograft, complete aneurysm exclusion and branch patency. Conclusion Single-branched thoracic stentgrafts could be a good option in unfavourable anatomies with supra-aortic vessels disease involving the aortic arch, with good results in terms of morbidity and early outcomes.
Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors
Authors: Frade-Sosa Beatriz , Ponce Andrés , Inciarte-Mundo José , Morlà Rosa , Ruiz-Esquide Viginia , Macías Laura , Azuaga Ana Belen , Ramirez Julio , Cañete Juan D. , Yague Jordi , Auge Josep M. , Gomez-Puerta José A. , Sanmarti Raimon 
Published: September 2022

Objectives: To analyse the accuracy of plasma calprotectin in patients with rheumatoid arthritis (RA) receiving monoclonal antibodies against IL-6 receptors (anti-rIL-6) or JAK inhibitors (JAKis) in detecting ultrasound (US) synovitis and compare it with acute phase reactants [high-sensitivity C-reactive protein (hs-CRP) and ESR]. Methods: An observational cross-sectional study of RA patients receiving anti-rIL-6 (tocilizumab or sarilumab) or JAKi, (baricitinib or tofacitinib) was made. Plasma calprotectin for the diagnosis of US synovitis [synovial hypertrophy grade (SH) ⩾ 2 plus power Doppler signal (PD) ⩾ 1] was analysed using receiver operating characteristic curves (ROCs). The performance of ESR and hs-CRP was also studied. The three ROC curves were compared to determine which had the highest discriminatory power. Associations between plasma calprotectin and US scores were made using correlation analysis. Results: Sixty-three RA patients were included. Mean plasma calprotectin levels were significantly higher in patients with US synovitis than in those without (0.89 ± 0.85 vs 0.30 ± 0.12 μg/ml; p = 0.0003). A moderate correlation between calprotectin and all US scores (HS score Rho = 0.479; PD score Rho = 0.492; and global score Rho = 0.495) was found. The discriminatory capacity of plasma calprotectin showed an AUC of 0.795 (95% CI: 0.687–0.904). The AUC of hs-CRP and ESR was 0.721 and 0.564, respectively. hs-CRP serum levels showed a low positive correlation with the three US scores (Rho < 0.40). After analysis according to the drugs administered, the correlation disappeared in patients receiving anti-rIL-6. Conclusion: Plasma calprotectin may be a sensitive biomarker of synovial inflammation in RA patients treated with anti-rIL-6 or JAKi.