bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Behavioral Therapy Plus a Serious Game as a Complementary Tool for a Patient With Parkinson Disease and Impulse Control Disorder: Case Report
Authors: Mena-Moreno Teresa , Munguía Lucero , Granero Rosario , Lucas Ignacio , Sánchez-Gómez Almudena , Cámara Ana , Compta Yaroslau , Valldeoriola Francesc , Fernandez-Aranda Fernando , Sauvaget Anne , Menchón José M , Jiménez-Murcia Susana 
Published: September 2022

Background
Impulse control disorders (ICDs) are commonly developed among patients who take dopamine agonist drugs as a treatment for Parkinson disease (PD). Gambling disorder and hypersexuality are more frequent in male patients with PD, with a prevalence over 4% in dopamine agonists users. Although impulsive-compulsive behaviors are related to antiparkinsonian medication, and even though ICD symptomatology, such as hypersexuality, often subsides when the dopaminergic dose is reduced, sometimes ICD persists in spite of drug adjustment. Consequently, a multidisciplinary approach should be considered to address these comorbidities and to explore new forms of complementary interventions, such as serious games or therapies adapted to PD.

Objective
The aim of this study is to present the case of a patient with ICD (ie, hypersexuality) triggered by dopaminergic medication for PD. A combined intervention was carried out using cognitive behavioral therapy (CBT) for ICD adapted to PD, plus an intervention using a serious game—e-Estesia—whose objective is to improve emotion regulation and impulsivity. The aim of the combination of these interventions was to reduce the harm of the disease.

Methods
After 20 CBT sessions, the patient received the e-Estesia intervention over 15 sessions. Repeated measures, before and after the combined intervention, were administered to assess emotion regulation, general psychopathology, and emotional distress and impulsivity.

Results
After the intervention with CBT techniques and e-Estesia, the patient presented fewer difficulties to regulate emotion, less emotional distress, and lower levels of impulsivity in comparison to before the treatment. Moreover, the frequency and severity of the relapses also decreased.

Conclusions
The combined intervention—CBT and a serious game—showed positive results in terms of treatment outcomes.
A Conceptual Model of Experiences With Digital Technologies in Aging in Place: Qualitative Systematic Review and Meta-synthesis
Authors: Hechinger Mareike , Hentschel Diana , Aumer Christine , Rester Christian 
Published: September 2022

Background
Older adults with chronic illnesses or dependency on care who strive to age in place need support and care depending on their illness. Digital technology has enabled the possibility of supporting older adults in their wishes to age in place. However, current studies have mainly focused on the solitary evaluation of individual technologies or on evaluating technologies for specific illnesses.

Objective
This study aimed to synthesize research on the experiences of older people from the Western culture with chronic illnesses or care needs and their families with digital technology for aging in place. From the meta-synthesis, a model was derived that can be useful for the development of assistive devices in old age and that can support health care providers and professionals in their work with affected individuals.

Methods
A systematic review and qualitative meta-synthesis was performed using an inductive approach, as proposed by Sandelowski and Barroso. We performed a systematic literature search in 6 databases from 2000 to 2019, with an update in 2021 and, in addition, conducted a hand search in 2 databases, relevant journals, and reference lists. The results of each study were analyzed using initial and axial coding, followed by theoretical coding. A conceptual model was derived.

Results
A total of 7776 articles were identified. Articles were screened independently by 2 authors based on the eligibility criteria. Finally, of the 7776 studies, 18 (0.23%) were included in the meta-synthesis. The derived conceptual model describes older adults with chronic illnesses or dependency on care and their family members in an individual process of reflection and decision-making, starting with the use of a digital device. Older adults live in times of change. They experience stable and unstable times of illness as they are part of a changing digital world. Hence, older adults and their families consider digital technology a solution to their current situation. As they become familiar with a specific digital technology, they refine their needs and demands, gain confidence in its use, and note its advantages and disadvantages. They weigh hopes, needs, demands, and experiences in a process of reflection to decide on convenience and inconvenience. Independent of their decision, they achieve peace of mind either with or without digital technology. This process can restart repeatedly during the illness trajectory of older adults.

Conclusions
This study promotes a differentiated understanding of older adults’ experiences with digital technology. The conceptual model can be useful for the development of assistive technology in old age. Moreover, it can guide health care professionals in their work with older adults and their families to provide individual counseling to find the appropriate digital technology for their respective situations.
Assessing the Acceptability of Home Blood Monitoring for Patients With Cancer Who Are Receiving Systemic Anticancer Therapy From a Patient, Caregiver, and Clinician Perspective: Focus Group and Interview Study
Authors: Vercell Amy , Taylor Sally , Yorke Janelle , Dowding Dawn 
Published: September 2022

Background
Regular blood testing is an integral part of systemic anticancer therapy delivery. Blood tests are required before every administration of treatment to ensure that a patient is sufficiently well to receive it. Blood testing is burdensome for patients as they require either an extra visit within 48 hours of planned administration of treatment or a significantly long visit if performed on the day of treatment. The additional time for appointments can have a significant impact on the quality of life of someone who is living with cancer. In the United Kingdom, the COVID-19 pandemic created unprecedented disruption to the delivery of cancer care. Face-to-face hospital visits were reduced, resulting in the need to develop more innovative ways of working to minimize treatment interruptions. This led to significant uptake of digital technologies, with new models of care rapidly deployed across the UK health service to meet these challenges.

Objective
This study aimed to explore the acceptability of a point-of-care home blood monitoring device for people with cancer who are receiving systemic anticancer therapy, which is being developed in response to the increased need for remote care for patients with cancer.

Methods
Qualitative focus groups and semistructured interviews were conducted with patients (23/47, 49%), caregivers (6/47, 13%), and health care professionals (18/47, 38%) over a 19-month time frame from May 2019 to December 2020. Data were analyzed using framework analysis guided by the Unified Theory of Acceptance and Use of Technology model.

Results
Analysis identified 4 overarching themes: performance expectancy, effort expectancy, social influence, and facilitating conditions.

Conclusions
This study found that patients with cancer, their caregivers, and health care professionals had positive perceptions about home blood monitoring. Although they are often considered synonymously, self-testing and self-management are not mutually exclusive, and this study illustrated some disparity in opinions regarding patient self-management. Home blood monitoring has the potential to provide patients with cancer with a convenient option for blood monitoring. It would minimize hospital attendances, decrease late treatment deferrals, and provide prompt recognition of cancer treatment toxicities, thus enhancing the existing nurse-led protocols and clinical pathways. Home blood monitoring would create a long-term sustainable transformation for the delivery of cancer care, using digital health to act as a facilitator to address a pertinent issue regarding improving the efficiency of hospital resources and increasing the delivery of personalized patient care. Further studies are needed to determine how and where home blood monitoring would fit within clinical pathways, in a way that is robust and equitable.
Group Antenatal Care in Ghana: Protocol for a Cluster Randomized Controlled Trial
Authors: Lori Jody R , Williams John E O , Kukula Vida A , Apetorgbor Veronica E A , Awini Elizabeth A , Amankwah Georgina , Zielinski Ruth , Lockhart Nancy , James Katherine H , Moyer Cheryl A 
Published: September 2022

Background
While group antenatal care (ANC) has been delivered and studied in high-income countries for over a decade, it has only recently been introduced as an alternative to individual care in sub-Saharan Africa. Although the experimental design of the studies from high-resource countries have been scientifically rigorous, findings cannot be generalized to low-resource countries with low literacy rates and high rates of maternal and newborn morbidity and mortality. The Group Antenatal Care Delivery Project (GRAND) is a collaboration between the University of Michigan in the United States and the Dodowa Health Research Centre in Ghana. GRAND is a 5-year, cluster randomized controlled trial (RCT). Our intervention—group ANC—consists of grouping women by similar gestational ages of pregnancy into small groups at the first ANC visit. They then meet with the same group and the same midwife at the recommended intervals for care.

Objective
This study aims to improve health literacy, increase birth preparedness and complication readiness, and optimize maternal and newborn outcomes among women attending ANC at seven rural health facilities in the Eastern Region of Ghana.

Methods
Quantitative data will be collected at four time points using a secure web application for data collection and a database management tool. Data will be analyzed on an intention-to-treat basis to test the differences between the two arms: women randomized to group-based ANC and women randomized to routine individual ANC. We will conduct a process evaluation concurrently to identify and document patient, provider, and system barriers and facilitators to program implementation.

Results
The study was funded in September 2018. Recruitment and enrollment of participants and data collection started in July 2019. In November 2021, we completed participant enrollment in the study (n=1761), and we completed data collection at the third trimester in May 2022 (n=1284). Data collection at the additional three time points is ongoing: 6 weeks postpartum, 6 months postpartum, and 1 year postpartum.

Conclusions
This study is significant and timely because it is among the first RCTs to be conducted to examine the effects of group ANC among low-literacy and nonliterate participants. Our findings have the potential to impact how clinical care is delivered to low-literacy populations, both globally and domestically, to improve maternal and newborn outcomes.

Trial Registration
ClinicalTrials.gov NCT04033003; https://clinicaltrials.gov/ct2/show/NCT04033003

International Registered Report Identifier (IRRID)
DERR1-10.2196/40828
Prevalence of Apparent Treatment-Resistant Hypertension in Chronic Kidney Disease in Two Large US Health Care Systems
Authors: An Jaejin , Kurella Tamura Manjula , Odden Michelle C. , Ni Liang , Thomas I-Chun , Montez-Rath Maria E. , Sim John J. 
Published: September 2022

Background and objectives
More intensive BP goals have been recommended for patients with CKD. We estimated the prevalence of apparent treatment-resistant hypertension among patients with CKD according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA; BP goal <130/80 mm Hg) and 2021 Kidney Disease Improving Global Outcomes (KDIGO; systolic BP <120 mm Hg) guidelines in two US health care systems.

Design, setting, participants, & measurements
We included adults with CKD (an eGFR <60 ml/min per 1.73 m2) and treated hypertension from Kaiser Permanente Southern California and the Veterans Health Administration. Using electronic health records, we identified apparent treatment-resistant hypertension on the basis of (1) BP above the goal while prescribed three or more classes of antihypertensive medications or (2) prescribed four or more classes of antihypertensive medications regardless of BP. In a sensitivity analysis, we required diuretic use to be classified as apparent treatment-resistant hypertension. We estimated the prevalence of apparent treatment-resistant hypertension per clinical guideline and by CKD stage.

Results
Among 44,543 Kaiser Permanente Southern California and 241,465 Veterans Health Administration patients with CKD and treated hypertension, the prevalence rates of apparent treatment-resistant hypertension were 39% (Kaiser Permanente Southern California) and 35% (Veterans Health Administration) per the 2017 ACC/AHA guideline and 48% (Kaiser Permanente Southern California) and 55% (Veterans Health Administration) per the 2021 KDIGO guideline. By requiring a diuretic as a criterion for apparent treatment-resistant hypertension, the prevalence rates of apparent treatment-resistant hypertension were lowered to 31% (Kaiser Permanente Southern California) and 23% (Veterans Health Administration) per the 2017 ACC/AHA guideline. The prevalence rates of apparent treatment-resistant hypertension were progressively higher at more advanced stages of CKD (34%/33%, 42%/36%, 52%/41%, and 60%/37% for Kaiser Permanente Southern California/Veterans Health Administration eGFR 45–59, 30–44, 15–29, and <15 ml/min per 1.73 m2, respectively) per the 2017 ACC/AHA guideline.

Conclusions
Depending on the CKD stage, up to a half of patients with CKD met apparent treatment-resistant hypertension criteria.
Entre la extinción y la reconversión: ¿por qué la radio se escucha cada vez menos?
Authors: Trejo Delarbre Raúl 
Published: September 2022

<p class="Cuerpo"><span lang="ES-TRAD">Hoy en día solamente 3.5 de cada 10 mexicanos escuchan radio. En 2005 casi 90 % de los hogares en México tenía, por lo menos, un aparato radiorreceptor; quince años después, solamente lo tenían en 51 % de las residencias. Esa caída de audiencias, principalmente, es resultado de la expansión de plataformas digitales y no está directamente vinculada con la situación socioeconómica de los radioescuchas. En este artículo se documenta esta drástica disminución de audiencias y, a partir de información de instituciones como el <span>inegi</span>, se muestra el interés por consumir este medio en cada estado del país. Se perfilan algunas explicaciones para comprender dicho cambio en la recepción de la radio. Como conclusión, planteamos que las opciones para el consumo de contenidos audiovisuales se han multiplicado, las nuevas audiencias buscan formatos más</span><span lang="es-419">flexibles</span><span lang="ES-TRAD"> y muchas personas diseñan su menú </span><span lang="es-419">de consumo mediático</span><span lang="ES-TRAD">, entre otras circunstancias. Finalmente, en México, su excesiva comercialización ha limitado la diversidad y calidad de sus contenidos.</span></p>
A Comparable genetic diversity between chicken ecotypes of different zones using DNA barcoding
Authors: Sabry Ayman , Ahmed  Mohamed Alaa , Hassan Mohamed , E. M. Abo-Aba Salah 
Published: September 2022

Objectives: The purpose of the current study was to verify the reliability of COI bar- codes in the assessment of genetic diversity of two ecotypes from different ecozones.
Methods: The DNA sequences of cytochrome oxidase I (COI) barcodes of 50 hens belonging to two ecotypes of Ismalia Egypt (ISM) and Taif Saudi Arabia (TA) were isolated and analyzed.
Results: This study results showed that no noticeable great differences among all barcode’s sequences of both ecotypes. The aver- age length of both ecotypes was 589 bp. ISM ecotypes have a relatively wider length range. The overall mean of GC% content was 48±0.01. Both ecotypes have the same number of sites 548 bp. ISM ecotype has 523 monomorphic sites whereas TA ecotype has slightly fewer monomorphic sites 517. The ISM ecotype has 7 singleton sites and 18 Parsimony informative sites. TA ecotype has little more polymorphic, that is 12 singleton sites and 19 Par- simony informative sites. The number of mutations (η) was larger in ISM (46) compared to 38 mutations for TA ecotype. Both ecotypes had the same number of Haplotypes (25), and haplotypes diversity (1) as well as the variance of haplotype diversity.
Conclusion: These results indicated a comparable level of genetic diversity of both ecotypes, which in turn may refer to a similarity of evolutionary forces that affect both ecotypes. Based on the present results, COI gene can be used in barcoding. The COI provides an objective the foundation for identification of ecotypes and therefore could be used for a rapid establishment of a variety of identifications.
Supporting Information for "Ingestible Functional Magnetic Robot with Localized Flexibility (MR-LF)"
Authors: Greenwood Taylor E. , Cagle Henry , Pulver Benson , Pak On Shun , Kong Yong Lin 
Published: September 2022

This Supporting Information includes information regarding the magnetic
field of the actuator magnet, MR-LF-S (which has the same geometry as
MR-LF and a soft compartment), and a table comparing MR-LF to other
small-scale, flexible magnetic crawler robots.
Corresponding author email: yong.kong@utah.edu
Haptoglobin Genotype Does Not Confer a Risk of Stroke in Type 1 Diabetes
Authors: Syreeni Anna , Dahlström Emma H. , Hägg-Holmberg Stefanie , Forsblom Carol , Eriksson Marika I. , Harjutsalo Valma , Putaala Jukka , Groop Per-Henrik , Sandholm Niina , Thorn Lena M. , Group on behalf of the FinnDiane Study 
Published: September 2022

<p>The exon copy number variant in the haptoglobin gene is associated with cardiovascular and kidney disease. For stroke, previous research is inconclusive. We aimed to study the relationship between haptoglobin Hp1/2 genotype and stroke in individuals with type 1 diabetes from the Finnish Diabetic Nephropathy Study. We included two partially overlapping cohorts: one with haptoglobin genotypes determined using genotyping for 179 stroke cases and 517 matched controls, and the other using haptoglobin genotype imputation for a larger cohort of 500 stroke cases and 3,806 controls. We observed no difference in the Hp1-1, Hp2-1, and Hp2-2 genotype frequencies between the stroke cases and controls, neither in the genotyping nor the imputation cohorts. Haptoglobin genotypes were also not associated with the ischemic or hemorrhagic stroke subtypes. In our imputed haptoglobin cohort, 61% of individuals with stroke died during follow-up. However, the risk of death was not related to the haptoglobin genotype. Diabetic kidney disease and cardiovascular events were common in the cohort, but the haptoglobin genotypes were not associated with stroke when stratified by these complications. To conclude, the Hp1/2 genotypes did not affect the risk of stroke or survival after stroke in our type 1 diabetes cohort.<br>
</p>
Monitoring the work of the test laboratory by participating in the proficiency testing program in the field of the laser performance measurements
Authors: Kolobrodov Valentin , Sokol Viktoriia , Polikarpov Oleksii , Sokol Bohdan 
Published: September 2022

Monitoring the validity result is the critical requirement of the international standard ISO/IEC 17025:2017 for test and calibration laboratories to provide objective evidence of their technical competence. Applying the interlaboratory comparison, using alternative instrumentation that has been calibrated, functional checks of measuring and testing equipment, and other methods for monitoring the validity of results is not enough to have confidence in the quality of test results. Modern standards in the field of quality for test and calibration laboratories require applying other forms for assessing the characteristics of the used test method. Particularly, it concerns the participation in interlaboratory comparisons.
One of the tools that could be used for monitoring the validity result is comparing laboratory test results with the results that are obtained by other laboratories, e.g. proficiency testing. This paper presents the result of a proficiency testing program for laser performance measurements that was organized by the International provider IFM Quality Services PTY Ltd. in 2021. The purpose of the paper is to demonstrate the results of the participation of the SE “Ukrmetrteststandard” in proficiency testing of measuring laser performance, to reveal the correlation of the results comparing with the previous years and different tasks and to assess the possible causes of outliers. Twenty-two laboratories that had been accredited by the ISO/IEC 17025 standard participated in the proficiency testing. The results were evaluated using the Z-score as the performance criterion.
Potential risks of proficiency testing with a small number of participants and possible causes of results outliers were assessed.
Metrological research of a reference installation based on a high-pressure vessel
Authors: Serediuk Orest , Serediuk Denis , Vynnychuk Anna 
Published: September 2022

The urgency of development and metrological research of reference installations based on high-pressure vessels, which meet the requirements of the implementation of traceability of instruments for measuring gas volume and gas volume flow rate, is considered. The operation algorithm of the specified reference installations when transferring the unit of gas volume to the gas meters under consideration is studied. Based on the algorithm and features of the operation of PVTt-type standards, a list of the analysed uncertainties of type A is formulated when estimating the volume of the calibrated high-pressure vessel; when measuring the absolute pressure and absolute temperature of gas due to the influence of instability of pressure and temperature on the gas meter under consideration due to the presence of a temperature gradient in the vessel. Uncertainties of type B, which are determined by metrological characteristics of measuring instruments, as well as the uncertainty of parameters evaluated by means of calculation, in particular the compressibility factor of the working environment, the influence of water vapour on the working environment and the influence of the discreteness of the device for collecting information about measurements from the gas meter are considered.
Formulas to quantify the combined uncertainty of measuring the volume of the calibrated vessel, the absolute pressure and absolute temperature as well as to calculate the air compressibility factor for the operating conditions of the installation are given. These parameters are the absolute pressure and absolute temperature of the gas and the compressibility factor of the working environment in the vessel at the beginning and at the end of the reproduction of the reference volume as well at the inlet of the gas meter. The expressions for calculating the combined and expanded uncertainties of PVTt-type standards are given.