bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorbidity and Polypragmasia in High and Very High Cardiovascular Risk Patients
Authors: Izmozherova N. V. , Popov A. A. , Kuryndina A. A. , Gavrilova E. I. , Shambatov M. A. , Bakhtin V. M. 
Published: March 2022

Aim. Assessment of the level and structure of polymorbidity, features of pharmacotherapy therapy in patients of different age groups, belonging to the category of high and extremely high cardiovascular risk, observed in outpatient clinics.Material and methods. The single-stage study included 282 patients of high and very high cardiovascular risk who were divided into three groups: (1) age 45-59 years, (2) 60-74 years, (3) ≥75 years. The structure of polymorbidity and features of pharmacotherapy in different age groups patients were evaluated. The frequency of polypragmasia was determined, and treatment adequacy in patients over 65 years of age was analyzed using the STOPP / START criteria and the Beers criteria of 2019.Results. High and very high cardiovascular risk patients have been found to be highly polymorbid, polimorbidity level increasing with age. Thus, among elderly patients, ischemic heart disease, chronic heart failure (CHF) were more often detected, as well as a high frequency of concomitant and background conditions, especially bone and joint system involvement (osteoarthritis, rheumatoid arthritis). Polypragmasia (administration of ≥5 drugs) was detected in 150 patients (53.2%) and was more common among elderly patients. According to Beers criteria, there were 48 cases of inadequate medication prescribing in 46 (28.0%) elderly patients. According to 80 STOPP criteria, 75 cases of prescribing potentially non-recommended drugs to 55 patients (32.1%) were detected. According to 34 START criteria, 116 cases of non-prescribing of necessary drugs to 52 (30.4%) elderly patients were found. When assessing the frequency of prognosis modifying medication prescribing, patients with CHF in 107 (63.0%) cases received angiotensin converting enzyme inhibitors, and in 42 cases (24.5%) angiotensin II receptor antagonists had been prescribed. Thus, 87.5% CHF patients were receiving renin-angiotensin-aldosterone system blockers. Statins were administered in 225 (79.8%) cases, antiplatelet agents were pre-scribed in 157 (67.9%) cases, and 23 persons (9.9%) were on oral anticoagulants for atrial fibrillation.Conclusion. In the structure of the studied cohort most of the high and very high cardiovascular risk outpatients were polimorbid, elderly and senile. Polypragmasia has been detected in more than half of elderly outpatients (53%), irrational medication was found in 28% to 30% elderly patients. Most patients with CHF were on statins, antithrombotic therapy, and renin-angiotensin-aldosterone system blockers.
Metformin in the management of patients with diabetes and advanced heart failure (HFrEF): a propensity score-matched analysis
Authors: Benes Jan , Kotrc Martin , Kroupova Katerina , Wohlfahrt Peter , Kovar Jan , Franekova Janka , Hegarova Marketa , Hoskova Lenka , Hoskova Eva , Pelikanova Terezie , Jarolim Petr , Kautzner Josef , Melenovsky Vojtech 
Published: March 2022

Abstract
Background: The role of metformin (MET) in the treatment of patients with advanced HFrEF and type 2 diabetes mellitus (DM) is not firmly established. We studied the impact of MET on metabolic profile, quality of life (QoL) and survival in these patients. Methods: A total of 847 stable patients with advanced HFrEF (57.4± 11.3 years, 67.7% NYHA III/IV, LVEF 23.6± 5.8%) underwent clinical and laboratory evaluation and were prospectively followed for a median of 1126 (IQRs 410; 1781) days for occurrence of death, urgent heart transplantation or mechanical circulatory support implantation. Results: A subgroup of 380 patients (44.9%) had DM, 87 of DM patients (22.9%) were treated with MET. Despite worse insulin sensitivity and more severe DM (higher BMI, HbA1c, worse insulin resistance), MET-treated patients exhibited more stable HF marked by lower BNP level (400 vs. 642 ng/L), better LV and RV function, lower mitral and tricuspid regurgitation severity, were using smaller doses of diuretics (all p< 0.05). Further, they had higher eGFR (69.23 vs. 63.34 ml/min/1.73m2) and better QoL (MLHFQ: 36 vs. 48 points, p= 0.002). Compared to diabetics treated with other glucose-lowering agents, MET-treated patients had better event-free survival even after adjustment for BNP, BMI and eGFR (p= 0.035). Propensity score-matched analysis with 17 covariates yielded 81 pairs of patients and showed a significantly better survival for MET-treated subgroup (p= 0.01).Conclusion: MET treatment in patients with advanced HFrEF and DM is associated with better quality of life and improved outcome, by mechanisms beyond the improvement of blood glucose control.
Training-induced change of tendon and muscle stiffness of the lower limb in professional female athletes: Assessment with shear wave elastography
Authors: Römer Claudia , Legerlotz Kirsten , Czupajllo Julia , Fischer Thomas , Wolfarth Bernd , Lerchbaumer Markus Herbert 
Published: March 2022

Abstract
Background: Shear Wave Elastography (SWE) is currently used to detect tissue pathologies. For preventive medicine, it may also be applied to uncover structural changes early on before they lead to functional impairment. Hence, it is important to examine the sensitivity of SWE and to investigate how stiffness measures are affected by methodological variables.Objective: To evaluate the acute effects of exercise activity on tendon and muscle stiffness measured by SWE.Methods: Standardized SWE examination of both lower limb tendon and muscles (achilles tendon (AT), Musculus soleus insertion (MS) and Musculus gastrocnemius (MG)) in longitudinal plane were performed in 24 healthy professional female athletes. Measurements were taken before and after a standardized treadmill exercise test. Baseline characteristics and parameters of performance were acquired. Results: In the overall cohort, baseline SWE assessment demonstrated a moderate to strong correlation between pre-exercise and post-exercise stiffness for MS (r=0.613), MG (r=0.609) and AT (r=0.583). In both muscles (Musculus soleus insertion and Musculus gastrocnemius) and achilles tendon, the linear regression shows an increase in stiffness for lower pre-exercise values and decreasing stiffness for higher pre-exercise values. This covariance between pre-exercise values and changes in stiffness is highly significant (p<0.001).Conclusion: SWE measurement revealed that in professional athletes acute exercise induces individually different tissue stiffness changes. Differences and changes of stiffness in professional athletes after acute exercise needed to be considered for diagnosing tendinopathy and injuries. More precise and comparable research protocols in MSK-SWE may be of great benefit for sports medicine but also for rehabilitation and preventive medicine.
Artificial intelligence-based imaging analysis of stem cells: a systematic scoping review protocol
Authors: Issa Julien , Chaar Mazen Abou , Kempisty Bartosz , Mozdziak Paul , Dyszkiewicz-Konwińska Marta 
Published: March 2022

Abstract

Objective: This scoping review aims to map and identify the available artificial intelligence-based imaging analysis of different stem cells types and characterization of stem cells differentiation and transdifferentiation pathways.Introduction: Stem cells are cells that can transform into more specialized cells and include pluripotent, embryonic, and adult subtypes. They are currently receiving huge attention due to the advancing technology of artificial intelligence(AI), a field that has found its way into many disciplines and reaching clinical settings. AI adopts multiple algorithms such as machine learning (ML), and the more useful deep learning (DL) as it provides convolutional neural networks (CNNs) capable of characterizing various stem cell differentiation pathways and classifying images based on their morphology, textures, and physical features thus allowing for future clinical utilization in regenerative medicine.Methods: Five different electronic databases (PubMed, Medline, Web of Science, Cochrane, and Scopus) will be searched, based on a specific searching strategy, for published studies investigating the artificial intelligence-based imaging analysis technique on various types of stem cells. Two independent reviewers will be screening the titles and abstracts of the collected studies, stored in Zotero 5.0, against the inclusion criteria; all potential studies will be subjected to a second examination for the full text before the final decision. Afterward, data will be extracted from the included articles and presented in a table.
Correlation between flooding and settlement planning in Nairobi
Authors: Owuor Martin Ochieng , Mwiturubani Donald Anthony 
Published: March 2022

Abstract
Globally, climate change triggers flooding through unpredictable, intermittent and incessant precipitation. Flooding in Nairobi is multi-factorial in causation. This has raised the question of necessary interventions in the design of urban settlements in order to reduce the impacts of extreme rainfall events that result in floods. This paper seeks to analyse the reciprocal correlation between settlement planning and pluvial flooding in Nairobi. Censuses data were obtained from the Kenya National Bureau of Statistics (KNBS) and daily rainfall records from the Kenya Meteorological Department spanning from 1961 to 2018. Other key parameters were drawn from extensive thematic content analyses of the existing literature. The data were subjected to trend and correlation analyses using the Stata and SPSS software to determine patterns and possible causal relationships. The results showed that there was an insignificant but positive relationship between the two variables with Pearson and Spearman coefficients of correlation of 0.211 and 0.111, respectively. The results of this study repudiate the perceived notion that occurrences of pluvial flooding in Nairobi have increased due to erratic precipitation patterns and improper planning of settlements. The null hypothesis is therefore upheld at 95% confidence level.
Long-term trends and projections of hydrological fluxes under RCP climate change scenarios for a mountainous river catchment of northeast India
Authors: Murasingh S. , Kuttippurath J. , Sandeep Dash S. , Raj S. , Remesan R. , Jha Madan K. , Kumar P. 
Published: March 2022

AbstractThe estimate of changes in hydrological fluxes from a climate change perspective is inevitable for assessing the sustainability of watersheds and conserving water resources. Here, we quantify and assess the changes in different hydrological flux components for the Manu-Deo River Basin (MDRB) of northeast India using Soil and Water Assessment Tool (SWAT) simulations and multi-temporal data at various resolutions. Sequential Uncertainty Fitting (SUFI-2) optimization is used to calibrate and validate the simulations for the periods 1984–2006 and 2007–2016 and for the four future representative concentration pathway (RCP) scenarios. The model performed reasonably well for the calibration and validation of daily data, in accordance with the Nash–Sutcliffe efficiency and coefficient of determination (0.54/0.55 and 0.52/0.72, respectively). The analysis for the period 1985–2013 reveals a decreasing trend in streamflow, which indicates increasing trends of drought there. Furthermore, it shows an increasing trend in evapotranspiration (ET) and decreasing trend for baseflow (BF), suggesting an adverse impact on agricultural production during lean periods. In addition, the RCP 2.6 and 6.0 scenarios for the monsoon season in future time scales are expected to cause a reduction in different flow components, although RCP 8.5 shows increased water availability there. The sub-basin-scale quantification and multi-temporal analysis of water availability under the present and future climate scenarios, as presented here, can assist water managers in formulating a suitable operational policy to implement a better decision-making framework for river and waterbody management. This is particularly important for mountainous regions, where input data are sparse and modelling of hydrological fluxes is challenging.
Curcumin as a Natural Modulator of B Lymphocytes: Evidence from In Vitro and In Vivo Studies
Authors: Haftcheshmeh Saeed Mohammadian , Mohammadi Asadollah , Mashayekhi Kazem , Navashenaq Jamshid Gholizadeh 
Published: March 2022

Abstract:
B cells are the only player of humoral immune responses by the production of various types of antibodies. However, B cells are also involved in the pathogenesis of several immune-mediated diseases. Moreover, different types of B cell lymphoma have also been characterized. Selective depletion of B cells by anti-CD20 and other B cell-depleting agents in the clinic can improve a wide range of immune-mediated diseases. B cells' capacity to act as cytokine-producing cells explains how they can control immune cells' activity and contribute to disease pathogenesis. Thus, researchers investigated a safe, low-cost, and effective treatment modality for targeting B cells. In this respect, curcumin, the biologically active ingredient of turmeric, has a wide range of pharmacological activities. Evidence showed that curcumin could affect various immune cells, such as monocytes and macrophages, dendritic cells, and T lymphocytes. However, there are few pieces of evidence about the effects of curcumin on B cells. This study aims to review the available evidence about curcumin's modulatory effects on B cells' proliferation, differentiation, and function in different states. Apart from normal B cells, the modulatory effects of curcumin on B cell lymphoma will also be discussed.
Proton Pump Inhibitors’ Use and Risk of Iron Deficiency Anaemia: A Systematic
Review and Meta-analysis
Authors: Ali Mohammad Daud 
Published: March 2022

Aim:
Various research was conducted during the last decade, with inconsistent findings regarding
iron death anaemia (IDA) perils vis-à-vis utilization of proton-pump inhibitors (PPIs). Consequently,
recent systematic review and meta-analysis were implemented to evaluate IDA-related perils
concerning the utilization of proton-pump inhibitors.

Methods:
The databases of EBSCOhost, PubMed® and Cochrane Central were searched from the research
outset until February 28, 2021 purposely to identify all research with objectives that align with
the present research investigation. The Newcastle-Ottawa Scale (NOS) was utilized for the evaluation
of the research investigation standard. The prime (1º) goal of the research was to gauge IDA peril
among users of proton-pump inhibitors (PPI). For data processing, RevMan (Review Manager) version
5.4 was employed.

Results:
In total, fourteen investigations research was employed in this systematic review and metaanalysis.
The combined relative risk of nine research exhibited a numerically consequential interrelation
betwixt the utilization of proton-pump inhibitors and IDA peril (RR 2.56 [95% CI 1.43–4.61], p <
0.00001). Contemporary systematic review and meta-analysis examination posit that proton-pump inhibitor
consumers are prone to greater peril of coming down with IDA in comparison to non-PPI users.

Conclution:
In keeping with the findings of my research, prescriber physicians should exercise caution
when prescribing PPIs to individuals taking it for a long time to avoid the peril of IDA. Additionally,
their serum iron level should be checked to ensure that proton-pump inhibitors are safe.
Peningkatan pengetahuan dan keterampilan pengelola bank sampah melalui sistem cerdas komunikasi pemasaran
Authors: Rozalena Agustin 
Published: March 2022

Munculnya keraguan dari masyarakat dalam mengelola bank sampah di Desa Sumbersari, Kecamatan Ciparay, Kabupaten Bandung sejauh ini dikarenakan masih terbatasnya pengetahuan dan pemahaman pengelolaan bank sampah secara umum. Informasi pengolahan sampah masih belum dianggap sebagai “sahabat” dalam menjaga kebersihan, lebih bermanfaat dan memiliki dampak ekonomi bagi hidup masyarakat. Salah satu alternatif dalam mendukung program penguatan bank sampah melalui peningkatan pengetahuan, pemahaman serta dukungan keterampilan di bidang komunikasi pemasaran. Bagi pengelola bank sampah, kegiatan ini dapat meningkatkan kemampuan komunikasi pemasaran dalam upaya lebih kreatif menyampaikan manfaat bank sampah dan prospek pemasaran sampah. Metoda pelaksanaan dalam mewujudkan program peningkatkan pengetahuan dan keterampilan pengelola bank sampah melalui metode penyuluhan terintegrasi dan pelatihan secara sistematis. Hasil pengabdian menunjukkan pengelola semakin memahami dan terampil dalam menerapkan praktik komunikasi pemasaran bank sampah kepada calon nasabah. Pengelola bank sampah lebih percaya diri dalam mengemban program kebersihan dan manfaat sampah ini, sehingga harapan masyarakat yang “bersahabat” dengan sampah dan kepedulian terhadap desa berbasis ecovillage dapat terwujud. Improvement of knowledge and skill of waste bank officers through marketing communication smart systems AbstractThe emergence of doubts from the community in managing the waste bank in Sumbersari Village, Ciparay District, Bandung Regency so far is due to the limited knowledge and understanding of waste bank management in general. Information about waste management is not yet considered as a "friend" in maintaining cleanliness, is more useful and has an economic impact on people's lives. One alternative is to support the garbage bank strengthening program through increased knowledge, understanding and skills support in the field of marketing communication. For officers, this activity can improve marketing communication skills in a more creative effort to convey the benefits of waste banks and the prospects for waste marketing. Implementation method in realizing the program to improve the knowledge and skills of waste bank officers through integrated counselling methods and systematic training. The results of the dedication show that officers are increasingly understanding and skilled in applying the practice of marketing communications of the waste bank to prospective customers. The officers are more confident in carrying out the cleanliness program and the benefits of this waste so that the hope of people who are "friendly" to waste and concern for the village based on ecovillage can be realized.
Pemberdayaan ekonomi kreatif berbasis kearifan lokal masyarakat dengan pendekatan outcome mapping
Authors: Sanuri Sanuri 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui penerapan pendekatan outcome mapping pada proses pemberdayaan ekonomi kreatif berbasis kearifan lokal masyarakat di kampung Kais-Tapuri, Distrik Kais, Kabupaten Sorong selatan, Papua barat. Penelitian ini merupakan penelitian participatory action research dengan menggunakan pendekatan kualitatif dan kuantitatif. Subjek penelitian terdiri dari 20 perempuan usia produktif. Data penelitian diperoleh dengan teknik observasi, wawancara, dan dokumentasi. Hasil penelitian adalah sebagai berikut: (1) Perencanaan partisipatoris untuk identifikasi kebutuhan terkait ekonomi rumah tangga bersama dengan kepala kampung, aparat kampung, perwakilan perempuan di dua kampung (2) Penentuan mitra langsung dan stakeholder potensial, mitra langsung yang terpilih terdiri dari 20 perempuan usia produktif dari dua kampung, dan stakeholder potensial terdiri dari kepala kampung, pendeta, kepala suku, dan kader posyandu (3) Desain program yaitu berupa rancangan terarah yang terdiri dari: visi dan misi, mitra langsung, capaian dambaan, penanda kemajuan (4) Menentukan rencana kerja berupa pelatihan dan pendampingan (5) Indikator keberhasilan pelatihan adalah adanya perubahan perilaku mitra langsung yang dapat dilihat pada penanda kemajuan yang sudah dibuat selama semester pertama Creative economy empowerment based on community local wisdom with outcome mapping approach AbstractThis research aims to determine the application of the outcome mapping approach to the process of creating economic empowerment based on local wisdom in the Kais-Tapuri village, Kais District, South Sorong Regency, West Papua. This research is participatory action research with qualitative and quantitative approaches. The research subjects consisted of 20 productive age women (housewives). The research data were obtained through observation, interview, and documentation techniques. The results of the research were as follows: (1) Participatory planning consisted of identifying needs related to household economics together with village heads, village officials, women representatives in two villages (2) Determination of Boundary partners and potential stakeholders, selected Boundary partners consisting of 20 women productive age of two villages, and potential stakeholders consist of village heads, pastors, chiefs, and Posyandu cadres (3) Program design is an intentional design consisting of vision and mission, boundary partners, Outcome challenges, progress marker (4) Determine work plans in the form of training and assistance (5) Indicators of successful training are changes in the behaviour of boundary partners that can be seen in the marker of progress made during the first semester
Model GELPITAS (gerak & lagu, picture & picture, talking stick) untuk meningkatkan perkembangan bahasa Inggris anak taman kanak-kanak
Authors: Purwanti Ratna , Suhaimi Suhaimi 
Published: March 2022

Tujuan Penelitian ini untuk mendeskripsikan motivasi dan aktivitas siswa serta hasil perkembangan bahasa inggris anak dengan menggunakan Gelpitas, karena pentingnya Bahasa Inggris untuk anak usia dini di masa emas agar dapat bersaing di dunia global ketika mereka beranjak dewasa nanti. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian yaitu Penelitian Tindakan Kelas (PTK) dalam empat pertemuan. Hasil penelitian menunjukan bahwa motivasi anak meningkat dan aktivitas anak secara klasikal dengan kategori sangat aktif. Hasil kemampuan anak mencapai ketuntasan klasikal dengan berkembang sangat baik dan telah memenuhi indikator keberhasilan. Dapat disimpulkan bahwa melalui Gelpitas (gerak dan lagu, model picture and picture, model Talking Stick) dapat meningkatkan kemampuan anak dalam perkembangan bahasa (Bahasa Inggris) pada anak Kelompok B Taman Kanak-kanak. GELPITAS model (gerak lagu, picture picture, talking stick) to improve development English early childhood AbstractThe purpose of this research is to describe student motivation and activities, the results of students' English development using Gelpitas, because of the importance of English for early childhood in the golden age to be able to compete in the global world when they grow up later. This study uses a qualitative approach to the type of research that is Classroom Action Research (CAR) in four meetings. The result shows that children motivation increases and the classical activities of children with a very active category. The results of children's ability to achieve classical completeness by developing very well and have met the indicators of success. It can be concluded that through Gelpitas (motion and song, picture and picture model, Talking Stick model) can improve children's ability in language development (English) in Group B Kindergarten children.