bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing Dynamic Impacts of Deagriculturalization on CO2 Emissions in Selected Asian Economies: A Tale of Two Shocks
Authors: Lin Siyuan , Zhou Ning , Jahangir Junaid , Sohail Sidra 
Published: January 2022

Abstract
The study investigates the symmetric and asymmetric impact of agriculturalization on environmental quality in sample of selected Asian economies for time period 1991 to 2019. For empirical analysis, the study adopted ARDL-PMG and NARDL-PMG approaches. The long-run findings of ARDL-PMG reveal that agriculturalization tends to significantly improve the quality of environment. The empirical outcomes of NARDL-PMG infer that positive shock in agriculturalization results in enhancing environmental quality, however, the negative shock in agriculturalization (i.e., de-agriculturalization) leads to deterioration of environmental quality in the long-run. The findings demonstrate that agriculturalization improves environmental quality and de-agriculturalization mitigates environmental quality. Based on these findings, the study recommends that the relevant authorities should formulate such reforms in the agriculture sector that controls and reduces carbon emissions in Asian economies.
Correction of Class II division 2 with crowding and bilateral fully transposed impacted mandibular canines
Authors: Han Lei , Mei Li , Zhang Caixia , Wu Tuojiang , Wang Congyue , Li Huang 
Published: January 2022

Abstract

Background
Maxillary canine impaction has been extensively reported, but studies of mandibular canine impaction are relatively few. Clinical studies and reports of experience treating mandibular canine impaction are of clinical benefit to both orthodontists and dentists.

Aims
This report introduces a Class II division 2 crowded case with severely impacted, fully transposed, mandibular canines treated by a non-extraction approach and mandibular arch expansion.

Methods
The completely transposed, impacted, mandibular canines were successfully aligned. The crowding was relieved by arch expansion and incisor proclination without obvious radiographic alveolar bone loss. The two severely labially displaced mandibular canines assisted in the expansion of the narrow mandibular arch.

Results
The maxillary and mandibular arches were expanded and well aligned, and Class II molar and canine relationships and a normal overjet and overbite were established. The mandibular canines were aligned in advantageous positions. There was no regional alveolar bone resorption around the mandibular canines.

Conclusion
The treatment approach provided an example of significant bone remodelling. Using the impacted mandibular canines for anchorage, the age of the patient provided an opportunity to adopt a relatively conservative and unique treatment approach which may be applied to relieve crowding.
A qualitative study of barriers and facilitators to adequate environmental health conditions and infection control for healthcare workers in Malawi
Authors: Tu Raymond , Elling Hayley , Behnke Nikki , Tseka Jennifer Mmodzi , Kafanikhale Holystone , Mofolo Innocent , Hoffman Irving , Cronk Ryan 
Published: January 2022

Abstract
The burden of healthcare-associated infections (HAIs) is high in low- and middle-income countries. Inadequate environmental health (EH) conditions and work systems contribute to HAIs in countries like Malawi. We collected qualitative data from 48 semi-structured interviews with healthcare workers (HCWs) from 45 healthcare facilities (HCFs) across Malawi and conducted a thematic analysis. The facilitators of infection prevention and control (IPC) practices in HCFs included disinfection practices, patient education, and waste management procedures. HCWs reported barriers such as lack of IPC training, bottlenecks in maintenance and repair, hand hygiene infrastructure, water provision, and personal protective equipment. This is one of the most comprehensive assessments to date of IPC practices and environmental conditions in Malawian HCFs in relation to HCWs. A comprehensive understanding of barriers and facilitators to IPC practices will help decision-makers craft better interventions and policies to support HCWs to protect themselves and their patients.
Estimation of greenhouse gas emissions of a tropical reservoir in Colombia
Authors: Rodríguez Diana C. , Peñuela Gustavo A. 
Published: January 2022

Abstract
Tropical reservoirs are generally flooded in soils with a high content of organic matter. This, combined with high temperatures, favors the generation of carbon dioxide and methane by biological degradation, contributing to the impact on climate change. A tropical reservoir in Colombia was monitored for 7 years in the pre-fill, fill and post-fill stages, for the last of these during the day and night. Emissions from diffusive fluxes at the surface of the water were measured using a floating static chamber, while inverted funnel methodology was used to measure the fluxes by bubbling. The samples collected in the field were analyzed in the laboratory using a gas chromatograph with a mass detector. The results showed average emissions of 70892.51±41079.16-ton CO2eq/year for pre-filling; 178254.53±105838.01-ton CO2eq/year for filling; and 466946.57-ton CO2eq/year for post-filling (for 5 years), concluding that the weather conditions and the filling percentage had an impact on the generation of greenhouse gases at filling and post-filling stages, as did the organic matter present in the area of influence of the sampling point. Higher greenhouse gas emissions were found during the day compared to the results at night, indicating that temperature affects these processes especially in tropical reservoirs.
Pumping test analysis for assessment of hydraulic parameters and aquifer system formation in hilly terrain
Authors: Singh Sonu , Tripura Joseph 
Published: January 2022

Abstract
Groundwater conditions (GWCs) of an area depends on aquifer hydraulic parameters such as storativity () or storage coefficient (), transmissivity () and hydraulic conductivity (). It plays a key role concerning groundwater flow modeling, well performance, solute and contaminant transport assessment and also for identification of areas for additional hydrologic testing. Specifically, the geologic formation of a region controls the porosity and permeability; however, in hilly terrain prospecting ground water potential is more challenging due to its limited extent and its occurrences that are usually confined to fractures and weathered rocks. The present study aims at estimating the hydraulic parameters through pumping test analysis to assess aquifer system formation on hilly terrain from 16 bore wells. The aforesaid parameters were examined through a case study in some selective regions of Hamirpur district of Himachal Pradesh, India. The study area is controlled under two main geological horizons that is the post-tertiary and tertiary. The papers end with comparative results of hydraulic parameters and the aquifer systems formation on different GWCs, which may be helpful in the outlook of sustainable groundwater resource in the regions.
Nitrogen resource recovery from mature leachate via heat extraction technology: An engineering project application
Authors: Xiong Jianying , Zhang Chen , He Pinjing , He Jun , Dai Xiaodong , Li Wudong , Yang Xiaoying , Li Xueting , Huang Xiaowen , Feng Jia 
Published: January 2022

Abstract
A large pool of ammonia in mature leachate is challenging to treat with a membrane bioreactor system to meet the discharge Standard for Pollution Control on the Landfill Site of Municipal Solid Waste in China (GB 16889-2008) without external carbon source addition. In this study, an engineering leachate treatment project with a scale of 2,000 m3/d was operated to evaluate the ammonia heat extraction system (AHES), which contains preheat, decomposition, steam-stripping, ammonia recovery, and centrifuge dewatering. The operation results showed that NH3-N concentrations of raw leachate and treated effluent from an ammonia heat extraction system (AHES) were 1,305–2,485 mg/L and 207–541 mg/L, respectively. The ratio of COD/NH3-N increased from 1.40–1.84 to 7.69–28.00. Nitrogen was recovered in the form of NH4HCO3 by the ammonia recovery tower with the introduction of CO2, wherein the mature leachate can offer 37% CO2 consumption. The unit consumptions of steam and power were 8.0% and 2.66 kWh/m3 respectively, and the total operation cost of AHES was 2.06 USD per cubic metre of leachate. These results confirm that heat extraction is an efficient and cost-effective technology for the recovery of nitrogen resource from mature leachate.
O URBANO, O PERIURBANO E O RURAL NA REGIÃO METROPOLITANA DE FORTALEZA
Authors: Gomes Iara , Amorim Noberto Pinto Deborah 
Published: January 2022

O artigo debate como a interação rural-urbana na Região Metropolitana de Fortaleza resulta em diversidade da agricultura e inovação rural. A área de influência da RMF ultrapassa o estado do Ceará, e se estende ao Rio Grande do Norte, Piauí e Maranhão. Sua produção agrícola abastece a área metropolitana, beneficiando-se de mercados próximos. Ademais, a pluriatividade de sua produção instiga-nos a compreender a mudança no sentido clássico da dinâmica rural. Nossa intenção é discutir as noções de periurbanidade e a singularidade do rural metropolitano. Expomos aqui elementos de pesquisa focada em evidenciar Caucaia, como município integrante da RMF, que se firma, enquanto componente desta região, por desempenhar diversas funções urbanas, e ao mesmo tempo por possuir uma agricultura que ocupa papel substancial para sua economia, a qual geralmente está associada com o rural.

Palavras-chaves: Urbano; Periurbano; Rural Metropolitano.
Sprawozdanie z konferencji naukowej „W poszukiwaniu przyrodniczego, filozoficznego i teologicznego obrazu Wszechświata”, Instytut Filozofii UKSW w Warszawie, 15.05.2021 r.
Authors: Świeżyński Adam 
Published: January 2022

15 maja 2021 roku odbyła się konferencja naukowa W poszukiwaniu przyrodniczego, filozoficznego i teologicznego obrazu Wszechświata, zorganizowana przez Instytut Filozofii Uniwersytetu Kardynała Stefana Wyszyńskiego w Warszawie. Okazją do zorganizowania konferencji była przypadająca 17 maja 2021 roku pierwsza rocznica śmierci ks. dr. hab. Grzegorza Bugajaka (1966-2020), wieloletniego pracownika Instytutu Filozofii UKSW i jego dyrektora w latach 2016-2020 oraz sekretarza redakcji czasopisma filozoficznego Studia Philosophiae Christianae w latach 1997-2020, redagowanego w Instytucie Filozofii UKSW. W konferencji, oprócz zaproszonych prelegentów, wzięli udział pracownicy Instytutu Filozofii UKSW oraz przedstawiciele innych ośrodków naukowych, a także przyjaciele i znajomi ks. Grzegorza Bugajaka.
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Zgłoszono: 07/08/2021. Zrecenzowano: 29/08/2021. Zaakceptowano do publikacji: 11/09/2021.
Pharmacokinetics-based Chronotherapy
Authors: Lu Danyi , Wang Zhigang , Wu Baojian 
Published: January 2022

Abstract:Dosing time-dependency of pharmacokinetics (or chronopharmacokinetics) has been long recognized. Studies in recent years have revealed that daily rhythmicity in expression of drug-metabolizing enzymes and transporters (DMETs) are key factors determining chronopharmacokinetics. In this article, we briefly summarize current knowledge with respect to circadian mechanisms of DMETs and discuss how rhythmic DMETs are translated to drug chronoeffects. More importantly, we present our perspectives on pharmacokinetics-based chronotherapy.
Cyclosporine Ameliorates Silica-Induced Autoimmune Hepatitis in
Rat Model by Altering the Expression of Toll-Like Receptor-4,
Interleukin-2, and Tumor Necrosis Factor-α
Authors: Abdelwahab Sayed F. , Mohammed Moustafa M. , Okasha Ahmed M. M. , Naiem Amany H. Abdel , Mohamed Reham F. , Mohamed Hatem A. 
Published: January 2022

Background:
Autoimmune hepatitis (AIH) is an inflammatory liver disease
that is characterized histologically by interface hepatitis, biochemically by elevated
transaminase levels, and serologically by the presence of autoantibodies. Toll-like
receptor (TLR)-4 is a TLR family member that, upon activation in hepatocytes, initiates a
cascade of events. Interleukin-2 (IL-2) and tumour necrosis factor α (TNF-α) are potent
inflammatory cytokines secreted in AIH, playing an important role in the early
development of inflammation and hepatocyte damage.

Objective:
This study examined the role of cyclosporine in AIH and illustrated its
actions on altered hepatic function in the silica-induced AIH model.

Methods:
AIH was induced in Wistar rats using sodium silicate. The rats were divided
into four groups: the control group, silica-AIH group, cyclosporine-treated group, and
prevention group. TLR-4 and IL-2 mRNA expressions in liver tissues were tested by RTPCR.

Results:
AIH was associated with up-regulation of liver enzymes, IL-2 and TLR-4 gene
expression, while cyclosporine significantly down-regulated the expression of both. The
relative quantity of TLR-4 mRNA was 1±0, 13.57±1.91, 4±0.38, and 2±0 in control, AIH,
cyclosporine, and prevention groups, respectively (p<0.001). Also, the relative quantity
of IL-2 mRNA was 1±0, 14.79±1.42, 7.07±0.96, and 3.4±0.55 in control, AIH,
cyclosporine, and prevention groups, respectively (p<0.001). Additionally,
immunohistochemical staining for TNF-α in liver sections was increased in the silica-AIH
group but was found to decrease in the cyclosporine-treated and prevention groups.

Conclusion:
This study advocates the therapeutic role of cyclosporine in treating
immune-mediated hepatic diseases. Cyclosporine improves histological alterations in the
liver and inhibits the production of proinflammatory cytokines.
Downregulation of CCKBR Expression Inhibits the Proliferation of Gastric
Cancer Cells, Revealing a Potential Target for Immunotoxin Therapy
Authors: Li Meng , Chang Jiang , Ren Honglin , Song Defeng , Guo Jian , Peng Lixiong , Zhou Xiaoshi , Zhao Ke , Lu Shiying , Liu Zengshan , Hu Pan 
Published: January 2022

Background:
Increased CCKBR expression density or frequency has been reported in
many neoplasms.

Objective:
We aimed to investigate whether CCKBR drives the growth of gastric cancer (GC) and
its potential as a therapeutic target of immunotoxins.

Methods:
A lentiviral interference system was used to generate CCKBR-knockdown gastric cancer
cells. Cell Counting Kit-8 and clonogenic assays were used to evaluate cell proliferation. Woundhealing
and cell invasion assays were performed to evaluate cell mobility. Cell cycle was analyzed
by flow cytometry. Tumor growth in vivo was investigated using a heterologous tumor transplantation
model in nude mice. In addition, we generated the immunotoxin FQ17P and evaluated the combining
capacity and tumor cytotoxicity of FQ17P in vitro.

Results:
Stable downregulation of CCKBR expression resulted in reduced proliferation, migration
and invasion of BGC-823 and SGC-7901 cells. The impact of CCKBR on gastric cancer cells was
further verified through CCKBR overexpression studies. Downregulation of CCKBR expression also
inhibited the growth of gastric tumors in vivo. Furthermore, FQ17P killed CCKBR-overexpressing
GC cells by specifically binding to CCKBR on the tumor cell surface.

Conclusion:
The CCKBR protein drives the growth, migration, and invasion of gastric cancer
cells, and it might be a promising target for immunotoxin therapy based on its aberrant expression,
functional binding interactions with gastrin, and subsequent internalization.
Novel 1,2-Thiazine-Pyridine Hybrid: Design, Synthesis, Antioxidant Activity and Molecular Docking Study
Authors: Bakr Rania B. , Elkanzi Nadia A.A. 
Published: January 2022

Background and Objectives:1,2-thiazine and pyridine heterocycles drew much attention due to their biological activities, including antioxidant activity. Based on fragment-based drug design, novel pyrido[1,2]thiazines 9a-c, thiazolidinopyrido[1,2], thiazines 10a-c and azetidinopyrido[1,2]thiazines 11ac were designed and prepared.Methods:These novel derivatives 9a-c, 10a-c and 11a-c were subjected to screening for their antioxidant activity via various assays as DPPH radical scavenging potential, reducing power assay and metal chelating potential.Results:All the assayed derivatives exhibited excellent antioxidant potential and the tested compounds 9a, 9b, 10a, 10b, 11a and 11b exhibited higher DPPH scavenging potential (EC50 = 32.7, 53, 36.1, 60, 40.6 and 67 μM, respectively) than ascorbic acid (EC50 = 86.58 μM). While targets 9a, 10a and 11a (RP50 = 52.19, 59.16 and 52.25 μM, respectively) exhibited better reducing power than the ascorbic acid (RP50 = 84.66 μM). The computational analysis had been utilized to prophesy the bioactivity and molecular properties of the target compounds.Conclusion:To predict the binding manner of the novel derivatives as antioxidants, in-silico docking study was performed on all the newly prepared compounds inside superoxide dismutase (SOD) and catalase (CAT) active site. The most active antioxidant candidate 9a (EC50 = 32.7 μM, RP50 = 52.19 μM) displayed excellent binding with Lys134 amino acid residing at Cu-Zn loop of SOD with binding energy score = -7.54 Kcal/mol, thereby increasing SOD activity and decreasing reactive oxygen species.
Identification of Plasmodium Secreted Proteins Based on MonoDiKGap
and Distance-Based Top-n-Gram Methods
Authors: Liao Xinyi , Gu Xiaomei , Peng Dejun 
Published: January 2022

Background:
Many malarial infections are caused by Plasmodium falciparum. Accurate
classification of the proteins secreted by the malaria parasite, which are essential for the development of
anti-malarial drugs, is necessary

Objective:
This study aimed at accurately classifying the proteins secreted by the malaria parasite

Methods:
Therefore, in order to improve the accuracy of the prediction of Plasmodium secreted proteins, we established a classification model MGAP-SGD. MonodikGap features (k=7) of the secreted
proteins were extracted, and then the optimal features were selected by the AdaBoost method. Finally,
based on the optimal set of secreted proteins, the model was used to predict the secreted proteins using
the Stochastic Gradient Descent (SGD) algorithm

Results:
We used a 10-fold cross-validation set and independent test set in the stochastic gradient descent
(SGD) classifier to validate the model, and the accuracy rates were found to be 98.5859% and
97.973%, respectively.

Results:
We used a 10-fold cross-validation set and independent test set in the stochastic gradient descent (SGD) classifier to validate the model, and the accuracy rates were found to be 98.5859% and
97.973%, respectively

Conclusion:
This study confirms the effectiveness and robustness of the prediction results of the
MGAP-SGD model that can meet the prediction requirements of the secreted proteins of Plasmodium
An Overview of the International Literature on Health-Related Quality of Life, Mental Health and Psychosocial Issues in People with Cancer
Authors: Lindert Jutta , Sancassiani Federica , Massa Elena , Nardi Antonio Egidio 
Published: January 2022

Background:
Cancer is one of the most important leading causes of death worldwide. Early detection, screening and diagnosis have been demonstrated to significantly improve patients’ survival rates and increase awareness of the benefit of prompt therapies and healthy lifestyles. In this context, Health-related Quality of Life (HRQoL) and several psychosocial difficulties are of relevance as prognostic factors for the trajectory of the diseases of people living with cancer.

Methods:
This Special Issue aims to present a set of systematic reviews and research studies focusing on several psychosocial aspects in people suffering from hematologic and solid cancer.

Results:
Three systematic reviews regard HRQoL, the quality of patient-physician communication, depression and other stress-related difficulties, respectively. One review pointed out the difficulties in diagnosing depression in the elderly with solid cancer; another one regards the risk of cancer in severe mental illnesses, such as schizophrenia, bipolar disorders, and severe depressive disorders. One additional review regards HRQoL in people with cancer in the present era of COVID-19 pandemic. Furthermore, some research studies pointed out the usefulness of a validated instrument to assess satisfaction with care in the oncology field, as well as of the self-reinforcing feedback loop to improve fatigue, insomnia and depression in people with cancer. Other two research studies evaluate, respectively, the attributable burden in worsening HRQoL in people suffering both from cancer and depression and the Type D personality as a risk factor for stress-related difficulties in women with breast cancer.

Conclusion:
This Special Issue is a contribution to enhance future research mainly about such interventions useful to assess and improve HRQoL and overall well-being in people with cancer.
Novel Coumarin Derivatives Containing a Triazole Moiety: A Study on Synthesis, Cytotoxicity, Membrane Dysfunction, Apoptosis, Cell Cycle, and Antiangiogenic Effects
Authors: Güner Adem , Bektaş Hakan , Menteşe Emre 
Published: January 2022

Background:
Coumarin is a functional compound with a pronounced wide range of biological activities and
has recently been shown to have anticancer effects on various human cancer cells. Cisplatin is widely used in treating
many cancers, but its effectiveness is limited due to acquired resistance and dose-related side effects.

Objective:
This study aimed to reveal the chemosensitizing ability of novel synthesized coumarin-triazole hybrid compounds
(3a-f) compared to the cisplatin in A549, MCF-7, and HeLa cancer cells.

Methods:
Cytotoxicity was determined by MTT assay. Lactate dehydrogenase (LDH), antioxidant/oxidant status, and
DNA fragmentation were determined spectrophotometrically using commercial kits. Muse™ Cell Analyzer was used
to assess cell cycle progression. Pro/anti-apoptotic gene expressions were determined by Real-Time qPCR. The antiangiogenic
activity was determined by VEGF expression and Hen's chorioallantoic membrane model.

Results:
Compounds 3c, -d, -e, and -f potentiated the cisplatin-induced cytotoxicity by increasing LDH release and
DNA fragmentation, inducing G2/M cell cycle arrest, overproducing oxidative stress, and decreasing cellular antioxidant
levels. These compounds combined with cisplatin caused upregulation in the pro-apoptotic Bax, Bıd, caspase-3,
caspase-8, caspase-9, Fas, and p53 gene expressions while downregulating anti-apoptotic DFFA, NFkB1, and Bcl2
gene expressions. These combinations caused vascular loss and a reduction in VEGF expression.

Conclusion:
These results suggest that a combinational regimen of coumarin compounds with cisplatin could enhance
the effect of cisplatin in A549 cells. Besides, these compounds exhibit relatively low toxicity in normal cells, thus
decreasing the dose requirement of cisplatin in cancer treatments.