bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial Risk Factors for Health-Related Quality of Life in Adult Congenital Heart Disease
Authors: Fteropoulli Theodora , Tyagi Manavi , Hirani Shashivadan P. , Kennedy Fiona , Picaut Nathalie , Cullen Shay , Deanfield John E. , Newman Stanton P. 
Published: March 2022

Background
There is variability in the impact of adult congenital heart disease (ACHD) on health-related quality of life (HRQoL). A greater insight into the impact of ACHD may be gained from investigating HRQoL in various diagnostic groups and considering the importance of psychosocial risk factors for poor HRQoL.

Objective
We compared the HRQoL of people with ACHD with normative data from the general population and among 4 diagnostic groups and identified risk factors for poor HRQoL in ACHD from a comprehensive set of sociodemographic, clinical, and psychosocial factors.

Methods
We conducted a cross-sectional study with 303 participants from 4 diagnostic groups Simple, Tetralogy of Fallot, Transposition of the Great Arteries, Single Ventricle who completed measures of illness perceptions, coping, social support, mood, and generic and disease-specific HRQoL. Data were analyzed using 1-sample t tests, analysis of variance, and hierarchical multiple regressions.

Results
There was diminished psychosocial HRQoL in the Simple group compared with the general population. Consistently significant risk factors for poor HRQoL included younger age, a perception of more severe symptoms due to ACHD, depression, and anxiety. Clinical factors were poor predictors of HRQoL.

Conclusions
The findings highlight the need to develop intervention studies aiming to improve HRQoL in people with ACHD and the routine assessment of illness perceptions and mood problems during key periods in people's lives. This will help address patient misconceptions that could be tackled by clinicians or specialist nurses during routine outpatient appointments and identify people in need of psychological support.
Four Questions Nurses Can Ask to Predict PTSD 1 Year After a Motor Vehicle Crash
Authors: Leroy Arnaud , Cottencin Olivier , Labreuche Julien , Mascarel Pauline , De Pourtales Marie-Atéa , Molenda Sylvie , Paget Virgine , Lemogne Cédric , Bougerol Thierry , Gregory Thomas , Chantelot Christophe , Demarty Anne-Laure , Meyer Samantha , Warembourg Frédérique , Duhem Stephane , Vaiva Guillaume 
Published: March 2022

BACKGROUND:
The role of nurses in screening for posttraumatic stress disorder is crucial in trauma units.

OBJECTIVES:
To create and evaluate an easy and brief tool for nurses to predict chronic posttraumatic stress disorder 1 year after a motor vehicle crash.

METHODS:
We performed a 1-year follow-up multicenter study from 2007 to 2015, including 274 patients injured in a motor vehicle crash who were hospitalized in an orthopedic trauma unit. Nurses administered the DEPITAC questionnaire. Posttraumatic stress disorder was measured by the Post-Traumatic Stress Disorder Checklist of symptoms during the first year following the crash. A multivariable logistic regression model was implemented to select items significantly associated with posttraumatic stress disorder to improve the DEPITAC questionnaire. Predictive performance to predict posttraumatic stress disorder 1 year after the motor vehicle crash was examined for these different models.

RESULTS:
Of 274 patients studied, a total of 75.9% completed the questionnaire at 1 year of follow-up. We found that only two questions and two simple elements of the patient's medical record (other injury or a person dying during the crash, perception of vital threat, number of children, and length of stay in trauma) predicted posttraumatic stress disorder 1 year after a motor vehicle crash.

CONCLUSIONS:
The brevity of this evaluation, simple scoring rules, and screening test performance suggest that this new screening tool can be easily administered in the acute care setting by nurses.
Association Between Body Mass Index and Morbidity and Mortality During Hospitalization After Trauma
Authors: Soliman Sara S. , Durling-Grover Renay , Bilaniuk Jaroslaw W. , Kong Karen , Renna Lauren , Hakakian Daniel , Rolandelli Rolando H. , Antonioli Luca , Nemeth Zoltan H. 
Published: March 2022

BACKGROUND:
Literature suggests that unhealthy body mass index is a risk factor for adverse clinical outcomes.

OBJECTIVES:
To study the association between unhealthy body mass index and morbidity and mortality after trauma using the 2016 American College of Surgeons Trauma Quality Improvement Program database.

METHODS:
A retrospective review was conducted comparing the normal weight control group to the underweight, overweight, obese, severely obese, and morbidly obese groups for differences in demographic factors, injury severity score, comorbidities, length of stay, and complications.

RESULTS:
Underweight, overweight, obese, severely obese, and morbidly obese body mass indexes, in comparison to normal weight body mass index, were associated with a higher probability of developing at least one complication after trauma. Additionally, we observed a J-shaped curve when analyzing body mass index and mortality, suggesting that both high and low body mass indexes are positively associated with mortality. In fact, morbidly obese patients had the highest mortality rate, followed by underweight patients (p < .001). Interestingly, however, multivariate logistic regression demonstrated that, compared with normal weight body mass index, overweight and obese body mass indexes were independently associated with 9.6% and 10.5% lower odds of mortality, respectively (p < .001 and p = .001).

CONCLUSION:
Irrespective of preexisting comorbidities, injury severity score, and mechanism of injury, underweight, overweight, obese, severely obese, and morbidly obese body mass indexes were independently associated with higher risks of morbidity, whereas overweight and obese body mass indexes were associated with lower mortality risks. These findings emphasize the complex relationship between body mass index and clinical outcomes for trauma patients.
Monitoring during extracorporeal membrane oxygenation
Authors: Castro Diana Morales , Morris Idunn , Teijeiro-Paradis Ricardo , Fan Eddy 
Published: March 2022

Purpose of review
Extracorporeal membrane oxygenation (ECMO) offers advanced mechanical support to patients with severe acute respiratory and/or cardiac failure. Ensuring an adequate therapeutic approach as well as prevention of ECMO-associated complications, by means of timely liberation, forms an essential part of standard ECMO care and is only achievable through continuous monitoring and evaluation. This review focus on the cardiorespiratory monitoring tools that can be used to assess and titrate adequacy of ECMO therapy; as well as methods to assess readiness to wean and/or discontinue ECMO support.

Recent findings
Surrogates of tissue perfusion and near infrared spectroscopy are not standards of care but may provide useful information in select patients. Echocardiography allows to determine cannulas position, evaluate cardiac structures, and function, and diagnose complications. Respiratory monitoring is mandatory to achieve lung protective ventilation and identify early lung recovery, surrogate measurements of respiratory effort and ECMO derived parameters are invaluable in optimally managing ECMO patients.

Summary
Novel applications of existing monitoring modalities alongside evolving technological advances enable the advanced monitoring required for safe delivery of ECMO. Liberation trials are necessary to minimize time sensitive ECMO related complications; however, these have yet to be standardized.
Small bowel lymphoma: clinical update and challenges for the gastroenterologist
Authors: Oka Priya , Sidhu Reena 
Published: March 2022

Purpose of review
The diagnosis of small bowel lymphoma (SBL) can be challenging, as they are very rare and also have a varied presentation. In this review, we aim to provide a broad overview of the types of SBL and also about the various modalities used for their diagnosis. We also discuss the overview of treatment strategies for a gastroenterologist.

Recent findings
Small bowel capsule endoscopy (SBCE) and devise-assisted enteroscopy (DAE) has revolutionized the way we investigate the small bowel. DAE also makes it possible to obtain histological samples for further characterization of SBL. This has led to a significant improvement in diagnosis and management of the disease in conjunction with cross-sectional imagining.

Summary
The diagnosis and management of small bowel lymphoma remains challenging despite the development of newer techniques such as SBCE and DAE. The current available diagnostic modalities have limitations; in the absence of a gold standard, the current investigative modalities compliment each other in reaching the final diagnosis.
The role of novel imaging in prostate cancer focal therapy: treatment and follow-up
Authors: Rothberg Michael B. , Enders Jacob J. , Kozel Zachary , Gopal Nikhil , Turkbey Baris , Pinto Peter A. 
Published: March 2022

Purpose of review
Multiparametric magnetic resonance imaging (mpMRI) has fundamentally changed how intraprostatic lesions are visualized, serving as a highly sensitive means for detecting clinically significant prostate cancer (csPCa) via image-targeted biopsy. However, limitations associated with mpMRI have led to the development of new imaging technologies with the goal of better characterizing intraprostatic disease burden to more accurately guide treatment planning and surveillance for prostate cancer focal therapy. Herein, we review several novel imaging modalities with an emphasis on clinical data reported within the past two years.

Recent findings
7T MRI, artificial intelligence applied to mpMRI, positron emission tomography combined with either computerized tomography or MRI, contrast-enhanced ultrasound, and micro-ultrasound are novel imaging modalities with the potential to further improve intraprostatic lesion localization for applications in focal therapy for prostate cancer. Many of these technologies have demonstrated equivalent or favorable diagnostic accuracy compared to contemporary mpMRI for identifying csPCa and some have even shown improved capabilities to define lesion borders, to provide volumetric estimates of lesions, and to assess the adequacy of focal ablation of planned treatment zones.

Summary
Novel imaging modalities with capabilities to better characterize intraprostatic lesions have the potential to improve accuracy in treatment planning, real-time assessment of the ablation zone, and posttreatment surveillance; however, many of these technologies require further validation to determine their clinical utility.
CDC26 Is a Key Factor in Human Oocyte Aging
Authors: Li Li , Xia Ye , Yang Yang , Zhang Wuwen , Yan Hua , Yin Ping , Li Kai , Chen Yuanyuan , Lu Lu , Tong Guoqing 
Published: March 2022

(Abstracted from Hum Reprod 2021;36:3095–3107)
Declining oocyte fertilization capacity and developmental potential, involving deficits in both nucleus and cytoplasm contributing to aberrant meiosis, is the major contributor to declining fertility and increased rate of congenital birth defects in women older than the age of 35 years. Oocyte aging is directly affected by a variety of factors, both environmental and intrinsic; however, the precise mechanism remains unclear.
The IARC Perspective on Cervical Cancer Screening
Authors: Bouvard Véronique , Wentzensen Nicolas , Mackie Anne , Berkhof Johannes , Brotherton Julia , Giorgi-Rossi Paolo , Kupets Rachel , Smith Robert , Arrossi Silvina , Bendahhou Karima , Canfell Karen , Chirenje Z. Mike , Chung Michael H. , del Pino Marta , de Sanjosé Silvia , Elfström Miriam , Franco Eduardo L. , Hamashima Chisato , Hamers Françoise F. , Herrington C. Simon , Murillo Raúl , Sangrajrang Suleeporn , Sankaranarayanan Rengaswamy , Saraiya Mona , Schiffman Mark , Zhao Fanghui , Arbyn Marc , Prendiville Walter , Indave Ruiz Blanca I. , Mosquera-Metcalfe Isabel , Lauby-Secretan Béatrice 
Published: March 2022

(Abstracted from N Engl J Med 2021;385:1908–1918)
In May 2018, the World Health Organization (WHO) called for the elimination of global cervical cancer as a major public health priority, with a 2-pronged approach focusing on effective vaccination against human papillomavirus (HPV) and the screening for and treatment of early cervical cancer. Cervical cancer is considered largely preventable through these programs; however, it continues to be disproportionately prevalent in countries with the lowest values on the Human Development Index.
The Effect of Arch Cartilage Graft and Tajima Reverse U Approach in the Secondary Reconstruction of Unilateral Cleft Lip Nasal Deformity
Authors: Lai Bo-Ru , Lo Chi-Chin , Lo Lun-Jou 
Published: March 2022

Abstract:
Secondary cleft lip nasal deformity is complicated with wide spectrum of defect and varied reconstructive procedures. There has been no unanimous solution for a given problem. In case of a localized alar depression in unilateral cleft lip nasal deformity, the conchal cartilage applied as arch graft was proposed. Patients were recruited from database of craniofacial center who received Tajima method and arch cartilage graft. Inclusion criteria were patients with unilateral cleft lip nasal deformity after skeletal maturity. Through a reverse U incision, the lower lateral cartilage was dissected and released from the skin and the contralateral cartilage. The harvested conchal cartilage graft was trimmed to 25 to 30 by 8mm in size, and inserted as arch shape overlying the cleft side lower lateral cartilage. Transdomal fixation sutures were made. Outcome assessment was performed, and the nostril and alar dimensions were measured. Thirty-nine patients were eligible for evaluation of the surgical outcome. Majority of patients underwent simultaneous lip revision (97%). No surgery-related complications were noted in this series. Satisfaction to the nasal reconstruction was reported in 85% of patients. Further minor nasal revisions were performed in 6 patients (15%). Quantitative measurement showed statistically significant improvement in nostril height, alar height and alar width after the surgery. It is concluded that the Tajima reverse U approach plus arch cartilage graft is an effective method for secondary reconstruction of the unilateral cleft lip nasal deformity in selected patients presenting with cleft side alar depression.5
Herpes Zoster Opthalmicus–Related Ophthalmoplegia: Anatomical, Pathogenetic, and Therapeutic Perspectives
Authors: Pupic–Bakrač Ana , Pupić–Bakrač Jure , Gabrić Ivana , Vukojević Nenad , Jukić Tomislav 
Published: March 2022

Objective:
To investigate the anatomical, pathogenetic, and pharmacological characteristics of herpes zoster ophthalmicus (HZO)– related ophthalmoplegia.

Methods:
Case report–based systematic review was performed.

Results:
This study included 96 patients (54 [56.25%] women and 42 [43.75%] men [P = 0.221]). The mean age at presentation was 64.32 ± 17.48 years. All the patients included in the study had HZO– related ophthalmoplegia, with rash presenting as initial symptom in 87 (90.62%) cases, and diplopia in 9 (9.38%) cases. Thirty–seven (38.54%) patients achieved complete recovery, whereas 59 (61.46%) patients had permanent ophthalmoplegia. Females recovered in 26/54 cases and males in 11/42 cases (P = 0.028). Recovery rates after peroral versus intravenous antivirals (15/38 versus 19/46) and > 10 days versus ≤10 days antiviral treatment (22/54 versus 12/30) did not significantly differ (P = 0.865 and P = 0.947, respectively). immunocompetent patients treated with corticosteroids had significantly better recovery rates compared to immunodeficient counterparts (17/34 [50.00%] and 5/22 [22.73%], respectively [P = 0.041]).

Conclusions:
The outcome of HZO–related ophthalmoplegia is associated with gender, immune status, corticosteroid use, and time of antiviral treatment initiation.
Inner Ear Anomalies in Children With Apert Syndrome: A Radiological and Audiological Analysis
Authors: Hogg Emma S. , Turgut Nesrettin F. , McCann Emma , Avula Shivaram , De Sujata , Sharma Sunil D. 
Published: March 2022

Introduction:
Apert syndrome is a multisystem genetic disorder typically characterized by craniosynostosis and syndactyly. Studies also report an increased incidence of hearing loss in children with Apert syndrome in comparison to the general population. The aim of this study was to gain an understanding of the inner ear radiological anatomical variations seen in children with Apert syndrome and correlate these with audiological outcomes.

Materials and Methods:
This was a retrospective review of computed tomography imaging of patients with Apert syndrome. Radiological images were examined for anatomical variations in inner ear structures. These were correlated with audiological testing.

Results:
Nineteen patients were included in the study. The most commonly observed anomaly was an absent bony window of the lateral semi-circular canal (SCC) in 11 patients (58%), followed by an enlarged lateral SCC in 12 patients (63%). This combination of anomalies was seen collectively in 42% of patients and together these give the appearance of a ’rectangular vestibular cavity’. Audiological results were available in 11 patients and 9 of these patients had a conductive hearing loss.

Conclusion:
To the authors’ knowledge, this is the first study that reports radiological findings alongside audiological testing in Apert syndrome and describes the appearance of a ’rectangular vestibular cavity’.
Nurses’ experience of using video consultation in a digital care setting and its impact on their workflow and communication
Authors: Razavi SeyedehMaryam , Farrokhnia Nasim , Davoody Nadia 
Published: March 2022

AbstractSweden as many other countries uses video consultation to increase patients’ access to primary healthcare services particularly during the COVID-19 pandemic. Working in digital care settings and using new technologies, in this case video consultations, require learning new skills and adoption to new workflow. The aim of this study is to explore nurses’ experience of using video consultation in a digital care setting and its impact on their workflow and communication. Fifteen semi-structured interviews were carried out with registered nurses recruited from a private digital healthcare provider. Interviews were recorded, transcribed, and analysed using an abductive approach. Nurses’ workflow was modeled, and several categories and subcategories were identified: nurses’ workflow (efficiency, flexibility, and information accessibility); communication (interaction with patients and interprofessional communication); user experience (change and development of the platform, challenges, and combining digital and physical care). Even though providing online care has its limitations, the nurses were positive towards using video consultations.
Gut microbiome composition better reflects host phylogeny than diet in breeding wood-warblers
Authors: Baiz Marcella D. , Benavides C. Andrea , Miller Eliot T. , Wood Andrew W. , Toews David P. L. 
Published: March 2022

AbstractUnderstanding the factors that shape microbiomes can provide insight on the importance of host-symbiont interactions and on co-evolutionary dynamics. Unlike for mammals, previous studies have found little or no support for an influence of host evolutionary history on avian gut microbiome diversity and instead have suggested a greater influence of the environment or diet due to fast gut turnover. Because effects of different factors may be conflated by captivity and sampling design, examining natural variation using large sample sizes is important. Our goal was to overcome these limitations by sampling wild birds to compare environmental, dietary, and evolutionary influences on gut microbiome structure. We performed fecal metabarcoding to characterize both the gut microbiome and diet of fifteen wood-warbler species across a four-year period and from two geographic localities. We find host taxonomy generally explained ∼10% of the variation between individuals, which is ∼6-fold more variation of any other factor considered, including diet diversity. Further, gut microbiome similarity was more congruent with the host phylogeny than with host diet similarity and we found little association between diet diversity and microbiome diversity. Together, our results suggest evolutionary history is the strongest predictor of gut microbiome differentiation among wood-warblers. Although the phylogenetic signal of the warbler gut microbiome is not very strong, our data suggest that a stronger influence of diet (as measured by diet diversity) does not account for this pattern. The mechanism underlying this phylogenetic signal is not clear, but we argue host traits may filter colonization and maintenance of microbes.
Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization
Authors: Trindade Pablo , Nascimento Juliana M. , Casas Bárbara S. , Faúndez Tomás Monteverde , Gasparotto Juciano , Ribeiro Camila Tiefensee , Devalle Sylvie , Sauma Daniela , Moreira José Claudio Fonseca , Gelain Daniel Pens , Porciuncula Lisiane O. , Palma Verónica , Martins-de-Souza Daniel , Rehen Stevens Kastrup 
Published: March 2022

SummaryMolecular and functional abnormalities of astrocytes have been implicated in the etiology and pathogenesis of schizophrenia (SCZ). In this study, we examined the proteome, inflammatory responses, and secretome effects on vascularization of human induced pluripotent stem cell (hiPSC)-derived astrocytes from patients with SCZ. Proteomic analysis revealed alterations in proteins related to immune function and vascularization. Reduced expression of the nuclear factor kappa B (NF-κB) p65 subunit was observed in these astrocytes, with no incremental secretion of cytokines after tumor necrosis factor alpha (TNF-α) stimulation. Among inflammatory cytokines, secretion of interleukin (IL)-8 was found particularly elevated in SCZ-patient-derived– astrocyte conditioned medium (ASCZCM). In a chicken chorioallantoic membrane (CAM) assay, ASCZCM reduced the diameter of newly grown vessels, and this effect could be mimicked with exogenous addition of IL-8. Taken together, our results suggest that SCZ astrocytes are immunologically dysfunctional and may consequently affect vascularization through secreted factors.