bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal diagnosis for fetuses with isolated and non‐isolated congenital heart defects using chromosomal microarray and exome sequencing
Authors: Xing Ya , Zhang Yun , Chen Jianping , Wu Fengyu , Yuan Meizhen , Zou Gang , Yang Yingjun , Zhou Fenhe , Zhou Jia , Sun Luming 
Published: May 2022

AbstractObjectiveTo investigate the use of chromosomal microarray (CMA) and Exome sequencing (ES) in fetuses with congenital heart disease (CHD).MethodsThe Fetal Medicine Unit of Shanghai First Maternity and Infant Hospital records were reviewed to ascertain all cases diagnosed with CHD by level 2 ultrasound examination between 2016 and 2019. Cases were categorized as isolated or associated with other abnormalities or fetal growth restriction. CMA was offered to all cases as a first‐line genetic test followed by ES when CMA was non‐diagnostic.ResultsOf the 586 ascertained, 84 (14.3%) had causative CMA abnormality, of which 8.8% (35/400) were in fetuses with isolated CHD and 26.3% (49/186) in those with other abnormalities. ES was performed in 47 cases with a negative CMA. Causative variants were identified in two (10.5%, 2/19) isolated cases and four(14.3%, 4/28) with other abnormalities.ConclusionInvasive procedures with CMA should be offered in pregnancies complicated by both non‐isolated and isolated cardiac abnormalities. When CMA is not diagnostic, ES can add diagnostic value in both groups and should be considered even for fetuses with an isolated CHD.
New data toward fulfilling the promise of the ICD‐11 severity criterion
Authors: Sharp Carla 
Published: May 2022

AbstractGreat progress has been made in furthering our understanding of the long‐term course of personality pathology. However, our knowledge about the long‐term outcomes of personality disorder, thus far, is based on a polythetic and categorical definition of personality disorder. This special issue brings together a set of papers reporting on the results of the 30‐year prospective study, the Nottingham Study of Neurotic Disorder, in addition to presenting a study protocol for a future study, the Boston (UK) Personality Project, and results from a study of lived experience of individuals who have been in treatment for personality challenges. Together, these papers highlight the value in viewing personality pathology not as a categorically defined disorder, but as a severity criterion related to functioning. This special issue paves the way for considering how to further refine and conceptualize the general severity criterion common to all manifestations (types) of personality disorder.
Molecular docking, synthesis, anticancer activity, and computational investigations of thiazole‐based ligands and their Cu(II) complexes
Authors: Jain Preeti , Guin Mridula , De Anindita , Singh Megha 
Published: May 2022

AbstractPresent work describes the preparation of Schiff base ligands named 2‐methoxy‐6‐[(E)‐(1,3‐thiazol‐2‐ylimino) methyl] phenol and its structure and activity comparison with another Schiff base N‐[(E)‐pyridin‐2‐ylmethylidene]‐1,3‐thiazol‐2‐amine. Cu(II) complex of both the ligands were prepared in 2:1 ratio in basic medium. UV‐Vis, FTIR, NMR spectroscopy, and other physicochemical techniques were used for characterization of synthesized compounds. The FTIR spectra of the ligands and their Cu(II) complexes evident the tetra dentate behavior of ligands and indicates the presence of nitrate groups. The geometry of synthesized ligands and complexes was optimized using density functional theory (DFT) with hybrid B3LYP functional. It confirms that the Cu(II) metal surrounded by tetra dentate ligand moiety was coordinated with oxygen atom of one nitrate group with bond lengths of 1.9668 Å for complex 1 and 2.2420 Å and 2.6220 Å for complex 2. Molecular docking study of synthesized molecules was performed against EGFR kinase (PDB:1m17) and tyrosine kinase (PDB:1 t46) molecular targets. The complex 1 has shown maximum inhibition with a binding energy of −10.40 kcal/mol against 1t46 molecular target. Further, ligand and complexes were analyzed by ADMET study, drug likeness, and bioactivity score by using online servers. Since these studies provided very significant results in terms of their binding energy with the target molecules and drug likeness score, time‐dependent in vitro anticancer activity of all compounds was also tested by using MTT assay against SCC4 cancer cell line. Complex 1 has shown promising activity with an IC50 value of 31.1 μM at 72 h time interval.
Temperature evolution and runoff contribution of three rock glaciers in Switzerland under future climate forcing
Authors: Pruessner Luisa , Huss Matthias , Farinotti Daniel 
Published: May 2022

AbstractWith ongoing climate change water availability in the source regions of alpine streams are at stake. In particular, dry mountain regions which currently rely on glacial meltwater will need to adapt. Since rock glaciers are more resilient to climate change and occur in nearly all high‐mountain catchments around the globe with some form of glacierization, it is of interest to investigate their contribution to runoff under different climate scenarios. Three well‐monitored rock glacier sites in the Swiss Alps (Murtèl, Ritigraben, and Schafberg) have been investigated under the climate change scenarios corresponding to low, medium and high greenhouse gas emissions to determine how their runoff contribution is affected. By the end of the 21st century, runoff from permafrost melting could account for 5–12% (12.0% for Murtèl, 7.0% for Ritigraben, and 5.0% for Schafberg) of monthly catchment runoff at maximum in an average year, and up to 50% in extreme years. For the low‐emission scenario, little change in the runoff contribution from rock glaciers is found, while the medium‐emission scenario shows increased variability and a shift in the seasonal runoff peak to earlier in the year. The high‐emission scenario indicates a further increase in the variability of the permafrost runoff contribution and also the development of a secondary seasonal peak in autumn, most prominently in the late century.
Gut microbiota dysbiosis in 4‐ to 6‐year‐old children with obstructive sleep apnea–hypopnea syndrome
Authors: Wu Junhua , Lu Yanbo , Cai Xiaohong , Chen Yuanyuan , Shen Zhisen , Lyv Qin 
Published: May 2022

AbstractObjectiveSeveral experiments on animals have reported the relationship between obstructive sleep apnea–hypopnea syndrome (OSAHS) and gut microbiota. We investigated the gut microbiota composition of children aged 4–6 years with OSAHS to complement the pathogenesis and clinical screening methods of OSAHS.MethodsWe collected feces from 43 children with OSAHS and 45 controls aged 4–6 years. We extracted total bacterial DNA from feces and analyzed the composition of gut microbiota through 16S ribosomal RNA sequencing.ResultsThere were significant differences in bacteria producing short‐chain fatty acids (SCFAs) between OSAHS children and controls, including Faecalibacterium, Roseburia, and a member of Ruminococcaceae. A gut microbiota model for pediatric OSAHS screening showed that the receiver operating characteristic‐area under the curve (ROC‐AUC) was 0.794 with 79.1% and 80.0% sensitivity and specificity, respectively. Functional analysis of the gut microbiota revealed several alterations in metabolism.ConclusionThe composition of gut microbiota in OSAHS children is partially changed. The altered intestinal flora may provide a new screening method for the diagnosis of children with OSAHS. The prediction of gut microbiota function suggests that intestinal metabolic function may be altered in OSAHS children.
Child maltreatment and asthma
Authors: Gaietto Kristina , Celedón Juan C. 
Published: May 2022

AbstractA growing body of evidence suggests a potential link between child maltreatment and asthma. Determining whether and how child maltreatment causes or worsens asthma would have major implications for disease prevention and treatment, as well as public health policy. In this article, we examine epidemiologic studies of child maltreatment and asthma and asthma‐related outcomes, review the evidence for potential mechanisms underlying the child maltreatment‐asthma association, and discuss future directions. To date, a child maltreatment‐asthma link has been reported in most studies of children and adults, though the type of maltreatment associated with asthma has differed across studies. Such discrepant findings are likely explained by differences in study design and quality. All studies have been limited by potential under‐reporting of child maltreatment and selection bias, and nonthorough assessment of asthma. Despite these limitations, the aggregate evidence from epidemiologic studies suggests a possible causal link between child maltreatment and asthma, though the relative contributions of various types of maltreatment (physical, sexual, emotional, or neglect) are unclear. To date, there is insufficient evidence of an association between child maltreatment and lung function in children or adults. Limited evidence further suggests that child maltreatment could influence the development or severity of asthma through direct effects on stress responses and anxiety‐ or depressive‐related disorders, immunity, and airway inflammation, as well as indirect effects such as increased obesity risk. Future prospective studies should aim to adequately characterize both child maltreatment and asthma, while also assessing relevant covariates and biomarkers of stress, immune, and therapeutic responses.
Back Cover Image, Volume 78, Issue 6
Authors: Yang Xiaoxue , Wang Zeyu , Geng Lili , Chi Baoyan , Liu Rongmei , Li Haitao , Gao Jiguo , Zhang Jie 
Published: May 2022

The back cover image is based on the Research Article Vip3Aa domain IV and V mutants confer higher insecticidal activity against Spodoptera frugiperda and Helicoverpa armigera by Xiaoxue Yang et al., https://doi.org/10.1002/ps.6858.image
The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects
Authors: Nattagh‐Eshtivani Elyas , Gheflati Alireza , Barghchi Hanieh , Rahbarinejad Pegah , Hachem Kadda , Shalaby Mohammed Nader , Abdelbasset Walid Kamal , Ranjbar Golnaz , Olegovich Bokov Dmitry , Rahimi Pegah , Gholizadeh Navashenaq Jamshid , Pahlavani Naseh 
Published: May 2022

AbstractThe prevalence of chronic diseases has increased significantly with the rising trend of sedentary lifestyles, reduced physical activity, and dietary modifications in recent decades. Inflammation and oxidative stress play a key role in the pathophysiology of several chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders. Since chronic diseases are not completely curable, various methods have been proposed for their control. Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. Furthermore, some previous studies have shown that PYC could effectively reduce inflammation through signaling the downstream of insulin receptors, inhibiting the phosphorylation of the serine residues of insulin receptor substrate‐1, reducing pro‐inflammatory cytokines and oxidative stress indices through the stimulation of antioxidant pathways, increasing free radical scavenging activities, preventing lipid peroxidation, and protecting the erythrocytes in glucose‐6‐phosphate dehydrogenase‐deficient individuals, although these effects have not been fully proved. The present study aimed to comprehensively review the evidence concerning the positive physiological and pharmacological properties of PYC, with an emphasis on the therapeutic potential of this natural component for enhancing human health.
Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review
Authors: Hipólito‐Reis Mariana , Neto Ana Catarina , Neves Delminda 
Published: May 2022

AbstractEndometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self‐controlled interventions including dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin, and resveratrol can act as natural interventions to control endometriosis. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines. A comprehensive search was carried out in PubMed, Scopus, and Web of Science to gather together all the articles that study the specific actions of curcumin, resveratrol, or quercetin in endometriosis pathophysiology. All types of study designs including experimental data were considered. Thirty articles, including a clinical trial, were included. For the assessment of the quality of the selected studies that globally have “good quality”, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used. By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis, angiogenesis and glucose and lipid metabolism, curcumin, quercetin, and resveratrol showed to have beneficial effects, evidencing their potential application in the endometriosis treatment. However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
Potential intestinal infection and faecal‐oral transmission of human coronaviruses
Authors: Ning Tingting , Liu Si , Xu Junxuan , Yang Yi , Zhang Nan , Xie Sian , Min Li , Zhang Shutian , Zhu Shengtao , Wang Youchun 
Published: May 2022

AbstractHuman coronaviruses (HCoVs) were first described in 1960s for patients experiencing common cold. Since then, increasing number of HCoVs have been discovered, including those causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the circulating coronavirus disease 2019 (COVID‐19), which can cause fatal respiratory disease in humans on infection. HCoVs are believed to spread mainly through respiratory droplets and close contact. However, studies have shown that a large proportion of patients with HCoV infection develop gastrointestinal (GI) symptoms, and many patients with confirmed HCoV infection have shown detectable viral RNA in their faecal samples. Furthermore, multiple in vitro and in vivo animal studies have provided direct evidence of intestinal HCoV infection. These data highlight the nature of HCoV GI infection and its potential faecal‐oral transmission. Here, we summarise the current findings on GI manifestations of HCoVs. We also discuss how HCoV GI infection might occur and the current evidence to establish the occurrence of faecal‐oral transmission.
Confining ZnS/SnS2 Ultrathin Heterostructured Nanosheets in Hollow N‐Doped Carbon Nanocubes as Novel Sulfur Host for Advanced Li‐S Batteries
Authors: Yan Bo , Li Yan , Gao Lin , Tao Huachao , Zhang Lulu , Zhong Shengkui , Li Xifei , Yang Xuelin 
Published: May 2022

AbstractHollow nanostructured hosts are important scaffolds to achieve high sulfur loading, fast charge transfer, and conspicuous restraint of lithium polysulfides (LiPSs) shuttling in lithium‐sulfur (Li‐S) batteries. However, developing high‐efficiency hollow hosts for improving utilization and conversion of aggregated sulfur in the hollow chamber remains a longstanding challenge. Herein, hollow N‐doped carbon nanocubes confined petal‐like ZnS/SnS2 heterostructures (ZnS/SnS2@NC) as a conceptually novel host for Li‐S batteries are reported. Specifically, compared to consubstantial hollow double‐shelled hosts, the ZnS/SnS2@NC with higher effective active surface area brings dense contact with sulfur and enhances efficient adsorption sites for binding LiPSs and accelerating their conversion. Benefiting from the unique structure and sophisticated composition, the resulting S@ZnS/SnS2@NC cathodes exhibit 1294 mAh g−1 at 0.2 C, an ultralow capacity decay of 0.016% per cycle over 500 cycles at 1.0 C, and a high area capacity of 4.77 mAh cm−2 at 0.5 C (5.9 mg cm−2). Meanwhile, the performance evolution of S@ZnS/SnS2@NC cathodes under various sulfur loadings is further investigated by using EIS, which provides the beneficial guidance to explore viable strategies further optimizing their performance. This work sheds new insights into the design of hollow nanostructured hosts with a distinguished ability to regulate LiPSs in Li‐S batteries.
A secure neural network‐based ranking approach for document searching in cloud data center
Authors: Malhotra Sheenam , Singh Williamjeet 
Published: May 2022

AbstractCloud computing has gained attention due to its sophisticated processing architecture and data storage capabilities in the last couple of years. Due to high volume data and the endless number of possible users, the security of the account holder's stored data and privacy becomes essential for this paradigm. This article focuses on the encryption architecture of data storage and retrieval by creating an encrypted searchable index, which is inspired by symmetric searchable encryption. Ranking becomes a need for providing the best out of the search results to the user. This research article proposes an efficient and flexible artificial neural network (ANN) based ranking scheme to search for documents from the cloud server. The proposed algorithm architecture is segmented into three parts. The first part is the generation of the encryption index over the uploaded data, the second part is query analysis, and the third part is ranking. To consolidate the encryption mechanism, RSA, NTRU, and AES were used based on the requirement of the data. To orient the retrieval part, the degree of the top keyword in the server is determined by using term frequency with inverse document frequency schemes. The retrieved documents are further ranked using ANNs. The simulation setup was done on MATLAB 2016b having datasets from Kaggle (Twitter data) and FIRE dataset.
Trace level detection and quantification of genotoxic impurities 3‐amino‐4‐methylbenzoate, 3‐amino‐4‐methylbenzoic acid, and 3‐(4‐methyl‐1H‐imidazol‐1‐yl)‐5‐(trifluoromethyl) aniline in Nilotinib dihydrochloride active pharmaceutical ingredient using liquid chromatography‐tandem mass spectrometry
Authors: Puppala Ravi Kumar , Subbaiah Nelaturi , Maheswaramma K Sesha 
Published: May 2022

AbstractA selective and sensitive novel methods were developed and validated for identification and trace level quantification (0.5 ppm) of genotoxic impurities Methyl 3‐amino‐4‐methylbenzoate, 3‐amino‐4‐methylbenzoic acid, and 3‐(4‐methyl‐1H‐imidazol‐1‐yl)‐5‐(trifluoromethyl) aniline in Nilotinib dihydrochloride active pharmaceutical ingredient by using liquid chromatography‐tandem mass spectrometry. The developed and validated methods were more accurate and capable to confirm the m/z values of parent and fragment ions through mass spectrometry and tandem mass spectrometry for further fragmentation. In addition, the developed methods were validated through current regulatory guidelines with a lower detection level of 0.15 ppm and a quantification level of 0.5 ppm for all the three genotoxic impurities. The correlation coefficient was observed as 0.9997 for Methyl 3‐amino‐4‐methylbenzoate genotoxic impurity‐I, 0.9998 for 3‐amino‐4‐methylbenzoic acid, and > 0.9999 for 3‐(4‐methyl‐1H‐imidazol‐1‐yl)‐5‐(trifluoromethyl) aniline. The recovery percentage of all the three genotoxic impurities was found to be between 93% to 105%.
Ersatzneubau der Schwebefähre an der Eisenbahnhochbrücke Rendsburg
Authors: Schmachtenberg Richard 
Published: May 2022

AbstractDie Schwebefähre an der Eisenbahnhochbrücke Rendsburg versah von Dezember 1913 bis zur Kollision mit einem Frachtschiff im Januar 2016 ihren täglichen Dienst. Die Fähre musste wegen der Kollision neu gebaut werden. Am 4. März 2022 wurde der Ersatzneubau für den Verkehr freigegeben. Die Schwebefähre ist mit der Eisenbahnhochbrücke Rendsburg ein historisches Wahrzeichen und ein Zeugnis deutscher Ingenieurkunst.
Effect of dietary roasted and autoclaved full‐fat soybean on the performance of laying hens and egg quality traits
Authors: Karimi Zohreh , Torki Mehran , Abdolmohammadi Alireza 
Published: May 2022

AbstractContextFull fat soybean (FFSB) can be used in poultry diets as a source of fat and protein, without extra cost for oil extraction; however, raw FFSB contains several anti‐nutritional factors.AimsInvestigating the effects of replacing dietary soybean meal (SBM) with processed (roasted or autoclaved) FFSB on the performance of laying hens and egg quality traits.MethodsA total of 324 Bovans White strain laying hens were randomly selected and distributed in 54 replicate cages. Based on a completely randomized design with a 2 × 4 factorial arrangement of treatments plus a control group, nine diets in which SBM were replaced with 25%, 50%, 75% and 100℅ roasted or autoclaved FFSB, with six replicates (with six hens each), were evaluated during an 8‐week trial period (60–68 weeks).Key resultsSignificantly increased feed intake (FI) was observed in hens fed diets including autoclaved FFSB (p < 0.05). The interactions between SBM replacement level and processing on feed conversion ratio (FCR), egg production (EP) and egg mass (EM) were significant (p < 0.01). Hens fed the diet with 100% roasted FFSB instead of SBM showed poor performance in terms of FCR, EP and EM during the experimental period. The main effect of SBM‐replacing level on Haugh unit was significant (p < 0.05). The main effect of processing on shell thickness was significant (p < 0.05), so autoclaved FFSB caused higher eggshell thickness than control and roasted FFSB.ConclusionsReplacement of dietary SBM with autoclaved FFSB can improve laying hens’ performance in terms of FCR, EP, EM and eggshell quality and yolk colour.ImplicationsThe use of autoclaved FFSB to replace commercial SBM and its oil in the diet of laying hens is recommended. Feed factories can formulate the diets of laying hens with autoclaved FFSB without extra cost due to oil extraction soybeans.
A variant of multiple endocrine neoplasia type 1 in a dog?
Authors: Borgonovi Simona , Scudder Christopher J 
Published: May 2022

AbstractA 9‐year‐old male neutered Cockerpoo dog was presented with pyrexia and was diagnosed with sterile idiopathic panniculitis. During initial investigations, advanced imaging revealed a suspected left‐sided cervical paraganglioma and bilateral adrenal masses. The dog underwent immunosuppression and achieved remission of the sterile idiopathic panniculitis. Bilateral adrenalectomy and paraganglioma excision were then performed. Histopathology identified bilateral adrenocortical carcinoma and cervical neuroendocrine carcinoma. Three months later, the dog was diagnosed with primary hyperparathyroidism. Despite left total thyroidectomy and parathyroidectomy, mild hypercalcaemia persisted for several months. Eight months later the dog became persistently hypokalaemic refractory to potassium supplementation, with metabolic alkalosis and systemic hypertension. The dog was euthanised 5 months later due to clinical deterioration. On postmortem examination, right parathyroid hyperplasia and metastatic neuroendocrine carcinoma involving liver, jejunum, pancreas and tracheobronchial lymph node were identified. This is the first report describing the concurrent presence of these types of endocrine neoplasms in a dog.