bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased Expression of ACADSB Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
Authors: Liu Xianhui , Zhang Weiyu , Wang Huanrui , Zhu Lin , Xu Kexin 
Published: January 2022

BackgroundPrevious reports have shown that short/branched chain acyl-CoA dehydrogenase (ACADSB) plays an important role in glioma, but its role in clear cell renal carcinoma (ccRCC) has not been reported.MethodsThe TIMER and UALCAN databases were used for pan-cancer analysis. RNA sequencing and microarray data of patients with ccRCC were downloaded from the Cancer Genome Atlas and Gene Expression Omnibus database. The differential expression of ACADSB in ccRCC and normal kidney tissues was tested. Correlations between ACADSB expression and clinicopathological parameters were assessed using the Wilcoxon test. The influences of ACADSB expression and clinicopathological parameters on overall survival were assessed using Cox proportional hazards models. Gene set enrichment analysis (GSEA) was performed to explore the associated gene sets enriched in different ACADSB expression phenotypes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on genes with similar expression patterns to ACADSB. Correlations between ACADSB and ferroptosis-related genes were assessed using Spearman’s correlation analysis.ResultsPan-cancer analysis revealed that ACADSB is down-regulated in multiple cancers, and decreased expression of ACADSB correlates with poor prognosis in certain types of cancer. Differential expression analyses revealed that ACADSB was down-regulated in ccRCC, indicating that ACADSB expression could be a single significant parameter to discriminate between normal and tumor tissues. Clinical association analysis indicated that decreased ACADSB expression was associated with high tumor stage and grade. The Cox regression model indicated that low ACADSB expression was an independent risk factor for the overall survival of patients with ccRCC. GSEA showed that 10 gene sets, including fatty acid (FA) metabolism, were differentially enriched in the ACADSB high expression phenotype. GO and KEGG pathway enrichment analysis revealed that ACADSB-related genes were significantly enriched in categories related to FA metabolism, branched-chain amino acid (BCAA) metabolism, and iron regulation. Spearman’s correlation analysis suggested that the expression of ACADSB was positively correlated with the expression of ferroptosis driver genes.ConclusionsACADSB showed good diagnostic and prognostic abilities for ccRCC. The downregulation of ACADSB might promote tumorigenesis and tumor progression by inhibiting FA catabolism, BCAA catabolism, and ferroptosis in ccRCC.
Factors Predicting Oncological Outcomes of Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma in Taiwan
Authors: Chen I-Hsuan Alan , Chang Chao-Hsiang , Huang Chi-Ping , Wu Wen-Jeng , Li Ching-Chia , Chen Chung-Hsin , Huang Chao-Yuan , Lo Chi-Wen , Yu Chih-Chin , Tsai Chung-You , Wu Wei-Che , Tseng Jen-Shu , Lin Wun-Rong , Jiang Yuan-Hong , Lee Yu-Khun , Jou Yeong-Chin , Cheong Ian-Seng , Hsueh Thomas Y. , Chiu Allen W. , Chen Yung-Tai , Chen Jih-Sheng , Chiang Bing-Juin , Tsai Yao-Chou , Lin Wei Yu , Wu Chia-Chang , Lin Jen-Tai , Yu Chia-Cheng 
Published: January 2022

BackgroundTaiwan is one of the endemic regions where upper tract urothelial carcinoma (UTUC) accounts for approximately a third of all urothelial tumors. Owing to its high prevalence, extensive experience has been accumulated in minimally invasive radical nephroureterectomy (RNU). Although a variety of predictive factors have been explored in numerous studies, most of them were on a single-center or limited institutional basis and data from a domestic cohort are lacking.ObjectiveThis study aims to identify significant predicting factors of oncological outcomes, including overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and intravesical recurrence-free survival (IVRFS), following RNU for UTUC in Taiwan.MethodsA multicenter registry database, Taiwan UTUC Collaboration Group, was utilized to analyze oncological outcomes of 3,333 patients undergoing RNU from 1988 to 2021 among various hospitals in Taiwan. Clinicopathological parameters were recorded according to the principles established by consensus meetings. The Kaplan-Meier estimator was utilized to estimate the survival rates, and the curves were compared using the stratified log-rank test. Univariate and multivariate analyses were performed with the Cox proportional hazard model to explore potential predicting factors.ResultsWith a median follow-up of 41.8 months in 1,808 patients with complete information, the 5-year IVRFS, DFS, CSS, and OS probabilities were 66%, 72%, 81%, and 70%, respectively. In total, 482 patients experienced intravesical recurrence, 307 died of UTUC, and 583 died of any cause. Gender predominance was female (57%). A total of 1,531 patients (84.7%) had high-grade tumors; preoperative hydronephrosis presented in 1,094 patients (60.5%). Synchronous bladder UC was identified in 292 patients (16.2%). Minimally invasive procedures accounted for 78.8% of all surgeries, including 768 hand-assisted laparoscopic (42.5%) and 494 laparoscopic (27.3%) approaches. Synchronous bladder UC was the dominant adverse predicting factor for all survival outcomes. Other independent predicting factors for OS, CSS, and DFS included age ≧70, presence of preoperative hydronephrosis, positive surgical margin, LVI, pathological T and N staging, and laparoscopic RNU.ConclusionSynchronous UC of the urinary bladder is an independent adverse prognostic factor for survival in UTUC. The presence of preoperative hydronephrosis was also corroborated as a disadvantageous prognostic factor. Our multivariate analysis suggested that laparoscopic RNU might provide better oncological control.
Transcriptomic and Lipidomic Profiles in Nasal Polyps of Glucocorticoid Responders and Non-Responders: Before and After Treatment
Authors: Zhu Zhenzhen , Wang Weiqing , Zha Yang , Wang Xiaowei , Wang Lei , Han Jinbo , Zhang Jianmin , Lv Wei 
Published: January 2022

Background:The pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and mechanisms underlying different responses to systemic glucocorticoids (GC) remain unclear. The major aim of this study was to explore the transcriptomic and oxidative lipidomic signatures and the effects of GC in patients with different clinical responses.Methods:Nasal polyp biopsies were obtained before and after 14-day oral GC treatment from 16 patients with CRSwNP, and normal nasal mucosa specimens were collected from 12 control subjects. RNA sequencing and oxidative lipidomics were performed, and differential gene expression analysis was conducted in the Responder and Non-responder groups at baseline and after treatment.Results:In the Responder group, GC significantly improved clinical symptoms and reduced tissue eosinophil infiltration. Meanwhile, GC led to a pronounced transcriptomic reversion with robust suppression of inflammatory responses and abnormal metabolism of extracellular matrix, as well as restoration of cilia function. However, non-responders were mainly characterized by epithelial hyperplasia and keratinization, with much less transcriptomic improvement after GC treatment. Higher expression of type 2 inflammatory molecules (CCL13, IGHE, CCL18, CCL23, CCR3,andCLC) with lower levels ofLACRT, PPDPFL, DES, C6, MUC5B,andSCGB3A1were related to a stronger clinical response to GC. Besides decreased prostaglandins and increased leukotrienes, increased dysregulation in other oxylipid mediators derived from polyunsaturated fatty acids was determined in nasal polyps, which was ameliorated by GC treatment.Conclusion:Systemic GC exert anti-inflammatory effects, improve tissue remodeling, restore cilia function, and ameliorate dysregulation of oxylipid mediator pathway in CRSwNP. GC-responders exhibited different transcriptomic signatures from non-responders.
Fluorescence Record Diagnostics of 3D Rough-Surface Landscapes With Nano-Scale Inhomogeneities
Authors: Angelsky O. V. , Bekshaev A. Y. , Zenkova C. Yu. , Ivansky D. I. , Zheng J. , Tkachuk V. M. 
Published: January 2022

The paper proposes a new approach that enables the structure analysis and reconstruction of a rough surface where the height of inhomogeneities (from the depression to the upper point) varies within the spread about 20 nm. For the surface diagnostics, carbon nanoparticles are used, which serve as sensitive probes of the local surface height. A single nanoparticle can be positioned at a desirable point of the studied surface with the help of an optical tweezer employing the He-Ne laser radiation. Then the particle is illuminated by the strongly focused exciting beam of 405 nm wavelength, with the waist plane precisely fixed at a certain distance from the surface base plane. The particle’s luminescence response (in the yellow-green spectral range) strongly depends on the distance between the exciting beam waist and the particle, thus indicating the local height of the surface. After scanning the surface area and the consecutive interpolation, the surface “vertical” landscape can be reconstructed with a high accuracy: the numerical simulation shows that the RMS surface roughness is restored with an accuracy of 6.9% while the landscape itself is reconstructed with the mean error 7.7%.
Relationships Between Self-Rated Health at Three Time Points: Past, Present, Future
Authors: Hinz Andreas , Friedrich Michael , Luck Tobias , Riedel-Heller Steffi G. , Mehnert-Theuerkauf Anja , Petrowski Katja 
Published: January 2022

Background: Multiple studies have shown that people who have experienced a serious health problem such as an injury tend to overrate the quality of health they had before that event. The main objective of this study was to test whether the phenomenon of respondents overrating their past health can also be observed in people from the general population. A second aim was to test whether habitual optimism is indeed focused on events in the future.Method: A representatively selected community sample from Leipzig, Germany (n = 2282, age range: 40–75 years) was examined. Respondents were asked to assess their current health, their past health (5 years before), and their expected future health (in 5 years) on a 0–100 scale. In addition, the study participants completed several questionnaires on specific aspects of physical and mental health.Results: Respondents of all age groups assessed their health as having been better in the past than it was at present. Moreover, they also assessed their earlier state of health more positively than people 5 years younger did their current state. Habitual optimism was associated with respondents having more positive expectations of how healthy they will be in 5 years time (r = 0.37), but the correlation with their assessments of their current health was nearly as high (r = 0.36).Conclusion: Highly positive scores of retrospectively assessed health among people who have experienced a health problem cannot totally be accounted for by a response to that health problem.
The Concept of Health-Promoting Collaboration—A Starting Point to Reduce Presenteeism?
Authors: Komp Rebecca , Kauffeld Simone , Ianiro-Dahm Patrizia 
Published: January 2022

Background: Since presenteeism is related to numerous negative health and work-related effects, measures are required to reduce it. There are initial indications that how an organization deals with health has a decisive influence on employees’ presenteeism behavior.Aims: The concept of health-promoting collaboration was developed on the basis of these indications. As an extension of healthy leadership it includes not only the leader but also co-workers. In modern forms of collaboration, leaders cannot be assigned sole responsibility for employees’ health, since the leader is often hardly visible (digital leadership) or there is no longer a clear leader (shared leadership). The study examines the concept of health-promoting collaboration in relation to presenteeism. Relationships between health-promoting collaboration, well-being and work ability are also in focus, regarding presenteeism as a mediator.Methods: The data comprise the findings of a quantitative survey of 308 employees at a German university of applied sciences. Correlation and mediator analyses were conducted.Results: The results show a significant negative relationship between health-promoting collaboration and presenteeism. Significant positive relationships were found between health-promoting collaboration and both well-being and work ability. Presenteeism was identified as a mediator of these relationships.Conclusion: The relevance of health-promoting collaboration in reducing presenteeism was demonstrated and various starting points for practice were proposed. Future studies should investigate further this newly developed concept in relation to presenteeism.
Gender Differences of Schizophrenia Patients With and Without Depressive Symptoms in Clinical Characteristics
Authors: Liu Ruimei , Fang Xinyu , Yu Lingfang , Wang Dandan , Wu Zenan , Guo Chaoyue , Teng Xinyue , Ren Juanjuan , Zhang Chen 
Published: January 2022

Objectives: To investigate the differences in psychotic symptoms and cognitive function in schizophrenics with and without depression and to compare gender differences in the correlation between depressive symptoms and clinical characteristics in those patients.Methods: A total of 190 schizophrenia patients and 200 healthy controls were recruited in the study. We used the Positive and Negative Symptom Scale (PANSS), the Calgary Depression Scale for Schizophrenia (CDSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to evaluate the psychiatric symptoms, depressive symptoms and cognitive function, respectively. Patients with CDSS score ≥7 were divided into depression group, and CDSS &lt; 7 was viewed as without depression.Results: Patients with schizophrenia had lower total scores of RBANS and five subscale (immediate memory, visual span, verbal function, attention, and delayed memory) scores compared to healthy controls. In the case group, patients who concomitant with depression had higher PANSS scores (Ps &lt; 0.001) and lower RBANS (Ps &lt; 0.05) scores than those without depression. After gender stratification, PANSS total scores and subscale scores were significantly different between schizophrenics with and without depressive symptoms in both male and female groups (Ps &lt; 0.001). For cognitive function, there were significant differences in RBANS total score and subscale scores except attention between female patients with and without schizophrenia but not in male schizophrenia patients. Furthermore, the correlation analysis showed that the total CDSS score was positively correlated with PANSS score (P &lt; 0.001) and RBANS score in male and female groups (male: P = 0.010, female: P = 0.001).Conclusion: Our findings provided evidence supporting the gender differences in psychiatric symptoms and cognitive function between schizophrenia patients with and without depressive symptoms.
Perceived Support and Sense of Social Belonging in Young Adults Who Have a Parent With a Mental Illness
Authors: Villatte Aude , Piché Geneviève , Benjamin Sylvie 
Published: January 2022

This participatory action research explores the perceived social support of youth whose parents have a mental illness during their transition to adulthood. Social support is an important protection factor during this developmental period, but few studies have explored how these young adults perceive their social support. Nor has any study assessed whether participation in a group-based participatory action research project could improve these youth's sense of support.Purpose: (1) identify which aspects of social support these youth spontaneously address when talking about their experiences in Photovoice workshops; (2) explore how participants view these types of workshops as a good way to improve their sense of social support and belonging.Methodology: Ten young adults (nine women and one man) between the ages of 18 and 25 who have at least one parent with a mental illness participated in Photovoice meetings in 2019. These group meetings aimed to explore and share their experiences as young adults whose parents have a mental illness. The testimonies were combined with data obtained from the abbreviated version of the Social Provisions Scale and the Scale of Social Belonging.Results: The quantitative results suggest that participants consider their social support levels to be high, but their qualitative statements highlight low level or absence of parental support in terms of emotional, informative or instrumental levels. They see themselves as an important source of support for their parent and discuss the importance of having other supports figures (romantic partner, employer, friends, sibling, etc.). Conversely, they have difficulty asking for help for various reasons (including fear of stigma). They consider that their participation in this Photovoice project allowed them to feel heard, supported and to develop a sense of belonging to a group.Discussion: To conclude, clinical issues to be considered for psychosocial intervention with young adults of parents with a mental illness are discussed.
A Web-Based Prediction Model for Cancer-Specific Survival of Elderly Patients With Early Hepatocellular Carcinoma: A Study Based on SEER Database
Authors: He Taiyu , Chen Tianyao , Liu Xiaozhu , Zhang Biqiong , Yue Song , Cao Junyi , Zhang Gaoli 
Published: January 2022

Background: Primary liver cancer is a common malignant tumor primarily represented by hepatocellular carcinoma (HCC). The number of elderly patients with early HCC is increasing, and older age is related to a worse prognosis. However, an accurate predictive model for the prognosis of these patients is still lacking.Methods: Data of eligible elderly patients with early HCC in Surveillance, Epidemiology, and End Results database from 2010 to 2016 were downloaded. Patients from 2010 to 2015 were randomly assigned to the training cohort (n = 1093) and validation cohort (n = 461). Patients' data in 2016 (n = 431) was used for external validation. Independent prognostic factors were obtained using univariate and multivariate analyses. Based on these factors, a cancer-specific survival (CSS) nomogram was constructed. The predictive performance and clinical practicability of our nomogram were validated. According to the risk scores of our nomogram, patients were divided into low-, intermediate-, and high-risk groups. A survival analysis was performed using Kaplan–Meier curves and log-rank tests.Results: Age, race, T stage, histological grade, surgery, radiotherapy, and chemotherapy were independent predictors for CSS and thus were included in our nomogram. In the training cohort and validation cohort, the concordance indices (C-indices) of our nomogram were 0.739 (95% CI: 0.714–0.764) and 0.756 (95% CI: 0.719–0.793), respectively. The 1-, 3-, and 5-year areas under receiver operating characteristic curves (AUCs) showed similar results. Calibration curves revealed high consistency between observations and predictions. In external validation cohort, C-index (0.802, 95%CI: 0.778–0.826) and calibration curves also revealed high consistency between observations and predictions. Compared with the TNM stage, nomogram-related decision curve analysis (DCA) curves indicated better clinical practicability. Kaplan–Meier curves revealed that CSS significantly differed among the three different risk groups. In addition, an online prediction tool for CSS was developed.Conclusions: A web-based prediction model for CSS of elderly patients with early HCC was constructed and validated, and it may be helpful for the prognostic evaluation, therapeutic strategy selection, and follow-up management of these patients.
Factores climático determinantes del rendimiento y la producción de papa en el distrito de Juli, Puno–Perú, 2000-2018
Authors: Quispe Mamani Julio Cesar , Apaza Mamani Edson , Marca Flores Omar Henry , Calcina Álvarez Dominga Asunción , Pumacallahui Salcedo Eliseo , Yapuchura Saico Cristóbal Rufino 
Published: January 2022

El objetivo fue encontrar los factores climáticos que determinan el rendimiento y la producción de papa en el distrito de Julia, entre los periodos 2000-2018, para lo cual se utilizó la información estadística de la Dirección Regional Agraria Puno y del Servicio Nacional de Meteorología e Hidrología de Puno. Se utilizó la metodología descriptiva y correlacional, considerando el modelo econométrico de tipo log-log. Se determinó que las variables climáticas como la temperatura mínima, la temperatura máxima determinan de manera positiva en el rendimiento de la producción y en la producción de papa y las precipitaciones de la lluvia determinan de manera negativa en el rendimiento de la producción y en la producción de papa. Finalmente, la temperatura mínima, la temperatura máxima y las precipitaciones explican al rendimiento de la producción y en la producción de papa en 97.96% y 97.95% respectivamente.
Propiedades físico-químicas y digestibilidad in vitro de mezclas alimenticias de cultivos andinos y cereales extruidos
Authors: Huanatico Suárez Elizabeth , Arisaca Parillo Adaliht Jhony , Quispe Alberto , Calla Florez Miriam , Zavaleta Huampa Percy , Quispe Callo Edgar Alcides 
Published: January 2022

El objetivo de la investigación fue formular una mezcla alimenticia a base de quinua, maca, cebada y arroz destinada a adultos mayores de acuerdo a las especificaciones de productos instantáneos. Asimismo, se determinó el efecto de cocción extrusión en las propiedades físico-químicas y digestibilidad in vitro de las mezclas seleccionadas. Para obtener la mejor formulación se utilizó el score de aminoácidos obteniendo 25 mezclas y que evaluadas por su calidad proteica, se tomaron 03 muestras, sometiéndose a un proceso de cocción por extrusión con una temperatura entre 140 y 165 °C y una humedad inicial entre 10 y 15 %, obteniéndose productos extruidos con un índice de gelatinización entre 94.34 a 95.87 %, 0.98 a 1.15 a meq/kg para el índice de peróxidos, valor proteico entre 7.4 y 10.33 %, y entre 1.54 y 1.73 % de fibra. La digestibilidad in vitro presentó valores entre 67.0 y 86.00. Se concluye que la mezcla óptima de acuerdo a los parámetros evaluados es la mezcla 3 compuesta por 30 % de maca, 25 % quinua, 35 % cebada y 10 % de arroz con un índice de gelatinización de 95.87 %, índice de peróxidos 0.98 meq/kg, Digestibilidad in vitro de 86 %, proteína 7.4%, fibra 1.54 %, grasa 2.5 %, las propiedades físico- químicas fueron influenciadas por la humedad inicial (10 y 15 %) y temperatura (160 – 165°C), en cuanto al análisis microbiológico de la mezcla seleccionada están dentro de los límites establecidos por la normativa vigente.
Relación entre la Planificación Estratégica y Gestión del Conocimiento
Authors: Gomez Zuñiga Fiorella 
Published: January 2022

En la actualidad, las instituciones muestran gran preocupación por la planificación de sus objetivos y actividades, asimismo requieren de conocimientos necesarios que permita cubrir las expectativos de sus usuarios o clientes. De ahí la necesidad de que conozcan estrategias de planificación y gestionen el conocimiento a fin de maximizar sus ganancias. por ello, este artículo tiene como finalidad analizar la relación entre la planificación estratégica y la gestión del conocimiento, específicamente dentro de la academia. Para ello, se realizó un estudio descriptivo correlacional, se usaron dos cuestionarios para el desarrollo de las dimensiones. Los resultados señalan que, definitivamente, se establece una correlación entre ambas variables en los profesores de la muestra elegida. También, se evidencia que hay correlación entre estas dimensiones de la planificación estratégica y las dimensiones de la gestión del conocimiento. Además, se encuentra del mismo modo, que los colaboradores de las sedes de Lima- Metropolitana los cuales se ubican en cinco distritos, sobre todo en Cercado de Lima.