bluuebunny/crossref_metadata_2025_split huggingface dataset:
. Reflection of individual typological properties in the tremorogram (Predicting the indicators of Rusalov’s test according to the indicators of the tremorogram)
Authors: Lobasyuk B. A. , Akimova L. N. , Stoyanov A. N. , Zamkovaya A. V. 
Published: January 2022

Rationale for choosing. An increase in physiological tremor (Tr) in emotionally saturated situations is reflected not only in fiction, but also in scientific literature. In other words, tremors and emotional responses are interconnected. Purpose. To investigate the reflection of individual-typological properties in a tremorogram using V. M. Rusalov’s mathematical modeling. Material and methods. Tr was recorded using a linear transducer. Tr was recorded under postural load (arms extended forward). The sensor was alternately placed on the outstretched right and left arms in front of oneself, under conditions of “eyes open” (operative rest). The analysis of the tremorogram (TrG) files was carried out after the end of the study using the "Analist - 2" software according to the half - period analysis algorithm. To study the individual psychological characteristics of the personality, we used the method of determining the properties of the temperament by V.M. Rusalov. Each of the many indicators of Rusalov’s test selected in the analysis was considered as a target feature (Y-s), and the amplitudes and frequencies of TrG were considered as influencing variables (sets of X - s) and multiple linear regression equations of the form were built: The parameters of the amplitude and frequency of EEG rhythms were used as Xs. Own research. In multiple regression analysis of the influence of TrG indices of the right hand on the indices of Rusalov’s test, 12 statistically significant regression coefficients were determined, and 11 statistically significant regression coefficients for the left hand. After obtaining the diagnostic equations of multiple linear regression, describing the influence of TrG indicators on the indicators of Rusalov’s test, an attempt was made, using these equations, to obtain the indicators of Rusalov’s test, using the tremor indicators. On average, the% discrepancy between the determined and predicted indicators was 97.42% for the right hand, and 101.98 for the left. Conclusions. 1. With the use of diagnostic equation, it was possible to predict the indicators of psychological testing according to Rusalov’s test by the indicators of tremor of the right and left hands.2. Influence of Rusalov’s test indicators on TrG indicators were less in modulus than the influence of TrG indicators on the indicators of Rusalov’s test, i.e. did not participate in the control of the mechanisms of TrG generation.3. The results obtained indicate that tremor indicators contain information about the subject-activity and communicative aspects of temperament according to V. M. Rusalov.
Pecularities of mental pathology at psychiatric patient with the comorbid somatic disorders
Authors: Oprya Ye. , Pustovoyt M. , Biesieda Ya. , Kozishkurt Ye. 
Published: January 2022

The paper presents the results of a comprehensive clinical and psychopathological examination of patients with schizophrenia comorbid with somatic pathology. The etiological factors and preconditions for the formation of schizophrenia combined with somatic pathology, general clinical and dynamic characteristics, and features of mental disorders, severity and specificity of clinical and psychopathological manifestations of schizophrenia are analyzed. It was found that the combination of schizophrenia with somatic diseases is more "malignant" variants of the course of psychotic disorders, including an increase in the number of hospitalizations, earlier manifestation, significant increase duration and greater severity of psychopathological symptoms.
The specificity of mental disorders in patients with schizophrenia with somatic disorders was manifested by a predominance of disorders of sensation and perception in the form of senestopathy (schizophrenia with CVD and F 20 with obesity), hyperesthesia (schizophrenia with diabetes 2) and complex hallucinations.
An important characteristic of mental disorders in patients with schizophrenia with somatic pathology is the presence of emotional disorders in the form of rigidity (in schizophrenia with CVD and obesity) and explosiveness (in schizophrenia with diabetes 2) emotional reactions, as well as depressive and anxiety (schizophrenia with CVD) and dysphoric (in schizophrenia with diabetes 2 and obesity) mood disorders. According to the frequency analysis of clinical-biological and social factors of formation, as well as features of clinical-psychopathological structure of schizophrenia in patients of the examined groups, diagnostic clinical-psychopathological signs (risk markers) of combination of schizophrenia with specific variants of somatic disorders are established.
The obtained results show that the combination of schizophrenia with somatic disorders is reflected in the deepening and peculiarities of psychopathological symptoms, reducing the level of social realization of patients and requires the attention of clinicians in developing treatment strategies.
The practices of antibiotics application in neurosurgical patients in Ukraine: a cohort study
Authors: Berezhna Antonina , Makarova Victoria , Chumachenko Tetyana 
Published: January 2022

Introduction. The outcomes of potential complications of surgical interventions in neurosurgical patients can cause a death. Efficient antibiotic prophylaxis decreases the risks of infection and improves the quality of health care.
Purpose. To estimate the appropriateness of prescribing antibiotics in a neurosurgical ward from the perspective of evidence-based medicine.
Material and method. A retrospective cohort study has been carried out in a neurosurgical ward of multidisciplinary healthcare setting of Ukraine. Data from 131 in-patient medical cards (MC) of neurosurgical patients has been analyzed. Descriptive statistics methods have been used for data analysis. The relative risk (RR) with the 95% confidence interval (95% CI) has been calculated.
Results. We found that among the patients, females prevailed (n = 81 / 61.8%). The patients’ mean age was 49.83 ± 13.90 years. The frequency of antibiotics prescriptions was higher significant in patients, who received surgical procedures in comparison with patients, who did not receive surgical procedures (RR = 1.827; 95% CI: 1,137 – 2.935). Antibiotics were prescribed mostly during the postoperative period. The use of interchangeable antibiotics of the same group has been occurred. The use of antibiotics for prevention in the most cases was of unreasonably long duration.
Conclusion. The practice of the use of antibiotics in neurosurgical ward does not correspond to scientifically founded recommendations. It is needed to clearly define the indications for prescribing antibiotics. Duration of antibiotic use should depend on specialization of wards in multidisciplinary healthcare setting. It is expedient to conduct an audit on the use of antibiotics at healthcare settings on a regular basis with involving a specialist in infection control, a clinical pharmacist, and a clinical microbiologist.
Cumulative cardiotoxic effect of bleomycin in experiment
Authors: Gozhenko A. , Bestanchuk O. , Kaschenko O. , Narbutova T. 
Published: January 2022

The aim of the study was to evaluate the cumulative toxic effect of bleomycin under experimental conditions
Material and Methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021. The experimental model of the cardiotoxic effect of the bleomycin was performed using the medication "Bleocin" manufactured by Nippon Kayaku Co., Ltd. (Japan). According to the task, the study was performed on 10 mature rats of both sexes of the Wistar line with a body weight of 237 ± 20 g.
Rats were housed in standard vivarium conditions of Odessa National Medical University. Animals were divided into 2 groups: experimental group (n = 5) and control (n = 5). Bleomycin animals of the experimental group were obtained intraperitoneally at a dose of 0.5 IU / kg on 1st and 8th days. Withdrawal of animals from the experiment was performed on the 5th, 14th and 28th day of the experiment, followed by morphological and morphometric examination.
The material after weighing and morphometry was fixed with a neutral 10% formalin solution and poured into paraffin. Histological sections were stained with hematoxylin-eosin, MSB, Van Gizon. Performed light microscopy.
After two weeks there was a decrease in myocardial weight by 7-10% from baseline, there were pronounced dystrophic changes in the myocardium. Repeated administration of bleomycin has a cumulative cardiotoxic effect leading to irreversible changes in the myocardium and endothelial dysfunction clinically manifested by heart attack, vascular pathology at significant cumulative doses of bleomycin. Morphofunctional changes of the right ventricle are prominent and considered to be pathognomic for bleomycin toxicity.
Conclusions: 1. Bleomycin has a cumulative toxic effect on the myocardium of mammals
2. The severity of the cardiotoxic effect of bleomycin is proportional to the tissue concentration of the drug, which is proportional to the duration of exposure
Social adaptive potential of mentally ill patients with concomitant pathology
Authors: Oprya Ye. , Melnyk E. , Biesieda Ya. , Kozishkurt Ye. 
Published: January 2022

The paper presents the results of research devoted to determination of social-adaptive potential of schizophrenic patients with concomitant somatic pathology by analyzing the parameters of socio-personal functioning, quality of life and compliance. The analysis of social and personal functioning of patients was carried out according to the results of the PSP scale (Personal and Social Performance Scale), which allowed to assess the social status of patients and their functioning in certain areas of life.
The quality of life of patients with schizophrenia in the surveyed groups was assessed using the results of the health questionnaire The 36-Item Short Form Survey (SF-36). According to the results of the research, it was found that when schizophrenia is combined with somatic disorders, there is a decrease in the level of socio-personal functioning, quality of life and compliance of patients. The social and personal functioning of patients with schizophrenia in its combination with somatic disorders was especially complicated in the areas of socially useful activities and self-care (in schizophrenia with obesity) and in the field of social relations and restless/aggressive patterns of behavior (in schizophrenia with DM 2).
According to the assessment of quality of life in certain areas, it was found that in patients with schizophrenia with CVD and obesity, there was a decrease in physical functioning and limitation of daily functioning due to physical condition, as well as mental depression (the presence of severe depression and anxiety); in patients with schizophrenia with DM 2 - a decrease in daily functioning, due to emotional state; and in patients with obesity - also a decrease in social functioning; and a general decline in general health that was common to all patients with somatic disorders. The decrease in the level of compliance of patients with schizophrenia with somatic disorders was due to insufficient formation of factors related to the patient (perception and awareness of the disease, features and severity of symptoms, relapses, features of social functioning and adaptation) and attitudes towards treatment. According to the data obtained, the most dangerous in focus of social functioning it was the combination of schizophrenia with obesity.
The results of the study show that the combination of schizophrenia with somatic diseases is associated with a decrease in social functioning, quality of life and compliance with patients, which leads to a negative social prognosis and requires the attention of clinicians.
Glutamine synthetase expression in the brain during experimental acute liver failure (immunohistochemical study)
Authors: Shulyatnikova T. , Tumanskiy V. 
Published: January 2022

The aim of the study was to determine the immunohistochemical level of glutamine synthetase (GS) expression in different brain regions in the conditions of experimental acute liver failure in rats.
Materials and methods. The study was conducted in Wistar rats: 5 sham (control) animals and 10 rats with acetaminophen induced liver failure model (AILF). The immunohistochemical study of GS expression in the sensorimotor cortex, white matter, hippocampus, thalamus, caudate nucleus/putamen was carried out in the period of 12-24 h after acetaminophen treatment.
Results. Beginning from the 6th hour after acetaminophen treatment all AILF-animals showed the progressive increase in clinical signs of acute brain disfunction finished in 6 rats by comatose state up to 24 h - they constituted subgroup AILF-B, “non-survived”. 4 animals survived until the 24 h - subgroup AILF-A, “survived”. In the AILF-B group, starting from 16 to 24 hours after treatment, a significant (relative to control) regionally-specific dynamic increase in the level of GS expression was observed in the brain: in the cortex – by 307.33 %, in the thalamus – by 249.47%, in the hippocampus – by 245.53%, in the subcortical white matter – by 126.08%, from 12th hour – in the caudate nucleus/putamen, by 191.66 %; with the most substantive elevation of GS expression in the cortex: by 4.07 times.
Conclusion. Starting from the 16th hours after the acetaminophen treatment (from the 12th h in the caudate nucleus/putamen region) and up to 24 h, it is observed reliable compared to control dynamic increase in GS protein expression in the cortex, white matter, hippocampus, thalamus, caudate nucleus/putamen of the rat brain with the most significant elevation in the cortex among other regions. The heterogeneity in the degree of GS expression rising in different brain regions potentially may indicate regions more permeable for ammonia and/or other systemic toxic factors as well as heterogeneous sensitivity of brain regions to deleterious agents in conditions of AILF. Subsequently, revealed diversity in the GS expression reflects the specificity of reactive response of local astroglia in the condition of AILF-encephalopathy during specific time-period. The dynamic increase in the GS expression associated with impairment of animal state, indicates involvement of increased GS levels in the mechanisms of experimental acute hepatic encephalopathy.
Organizational aspects of neurorehabilitation at the outpatient stage
Authors: Khramtsov D. , Vorokhta Yu. , Vikarenko M. , Busel S. , Sazonov B. 
Published: January 2022

The study was aimed to evaluate the effectiveness of IRP implementation in patients of a specialized clinic providing long-term care to neurological and neurosurgical patients.
Material and methods. The study was conducted in 2020-2021. on the basis of the MC "Expert Health" (Odessa, Ukraine). 83 patients undergoing neurorehabilitation program were examined. The correspondence of the fulfillment of key rehabilitation tasks in terms of time and quality was assessed. Additionally, the level of motivation and compliance of the patient was assessed using the MOT-Q questionnaires (for patients with previous TBI (n = 13), SRMS (for patients with stroke (n = 54) and with SRQ-E (for patients with other types of neurological pathology (n = 16). The overall level of compliance was assessed using the General Rehabilitation Adherence Scale (GRAS). The level of safety was assessed according to the following criteria: the presence of FAST certificates for personnel, a system for monitoring vital functions, equipment and consumables for the provision of emergency care. Statistical processing was carried out by methods of variance and correlation analysis, using the MedCalc 1.3 software.
Results. There were not recorded any significant violations of safety principles in the provision of rehabilitation assistance in the certification of personnel according to FAST. The frequency of detecting cases of improper implementation of IRP did not exceed 6.0% (5 cases out of 83 analyzed). When assessing the relationship between the effectiveness of IRP and the level of compliance, a strong positive correlation was found - r = 0.78
Conclusion. 1. Provision of rehab services for neurological patients in the long term requires coordination of the actions of specialists at the intra-, inter-, and transdisciplinary levels. 2. A necessary condition for the functioning of a multidisciplinary team in the provision of rehabilitation care is certification of staff in the BLS systems - for allied health specialists and ACLS for physicians. 3. The effectiveness of IRP depends on the patient's compliance level (r = 0.78). 4. For the continuity of the rehabilitation process, it is necessary to involve relatives and facilitate their training in the basics of "home" rehabilitation.
Adaptive griffiths scale − modern experience in assessing the psychomotor development of preschool children
Authors: Bedrii Nataliia 
Published: January 2022

Premature newborns build a specific category of children due to their innate morpho-functional immaturity and specific pathological conditions that determine significant survival, morbidity and postnatal care results as compared to children of other weight categories. In the long-term adverse effects of preterm birth, the incidence of neuropathy remains high and requires further improvements in diagnostic methods and timely corrections for a better developmental prognosis. Although over the past three decades, numerous tools have been invented to predict long-term adverse effects of preterm neonates as well as methods for determining degree of disorders, neither these tools nor their weak and strong points have undergone a comprehensive overview. Aim of the research was to improve long-term preterm birth outcomes by using the adaptive Griffiths scale for preschoolers. The psychomotor development of 105 preschoolers was evaluated. Assessment of indicators of psychomotor development was carried out by the adaptive Griffiths scale and the conventional method. In the course of the study, this category of children was under doctors' from Neonates Post-discharge Follow-ups Department with systematic evaluation of their health condition. Dynamic examination was performed during the first year of life once per 3 months, from the 2nd to the 6th year of life – corresponding to an individual rehabilitation plan. Patients (n=105) were divided into 3 groups depending on the severity of the disabling pathology.
The analysis of indicators of psychomotor development (by traditional methods) of prematurely born preschoolers, divided into 3 groups in accordance with severity degree of disabling pathology:
Group A children with severe long-term consequences that led to disability – 54 (51.4%)
Group B. Children with long – term consequences who are subject to correction - 24 (22.8%)
Group C. Children with long-term consequences not significantly affecting their health condition -27 (25.7%).
The conducted survey suggests, that above 70% of the children had various patterns of delayed psychomotor development. The assessment of psychomotor development showed that the cause structure of delayed psychomotor development of preschoolers has the same trend according to different examination methods, but the assessment by the adaptive Griffiths scale shows more accurate values for each patient, enables quick detection of long-term adverse consequences of premature birth, recommendations for parents for neonates' rehabilitation and habilitation, as well as examination in dynamics.
In the flow of the research, the adaptive Griffiths scale of psychomotor development proved to be a valid diagnostic tool for determining indicators of preschoolers' psychomotor development, estimating their intellectual coefficient and forming individual patient's profile.
Ocena zachowań zdrowotnych wśród studentów wybranych kierunków
Authors: Gałuszka Aleksandra 
Published: January 2022

Prowadzenie zdrowego trybu życia jest jednym z czynników warunkujących sprawność funkcjonowania i zdolność człowieka do pełnienia wybranych przez siebie ról społecznych. Tryb życia studentów uwarunkowany jest obciążeniami związanymi z procesem edukacji- presją czasu, stresem , odległością uczelni od miejsca zamieszkania, małą wiedzą związaną ze zdrowym trybem życia itd. W funkcjonowanie studentów wpisują się również zachowania, które pozwalają odreagować obciążenie psychiczne i fizyczne, dlatego włączane są: picie alkoholu, palenie papierosów i inne. Młody wiek sprzyja aktywności rozrywkowej, studenci uczestniczą w imprezach towarzyskich i kulturalnych, co w połączeniu z procesem edukacji powoduje przemęczenie a nawet wyczerpanie organizmu. Sposób funkcjonowania młodych ludzi jest niezwykle istotny, ponieważ poziom aktualnie doświadczanego stresu, presja czasu, to są zjawiska przemijające, natomiast skutki nimi spowodowane mogą posiadać charakter długodystansowy. Mogą wieźć do utrwalenia negatywnych wzorców (np. prowadzić do rozwoju nałogów, niehigienicznego trybu życia) lub wywołania schorzeń spowodowanych niewłaściwym trybem życia (otyłość, nowotwory i inne). Badaniem objęto studentów trzech kierunków: ekonomii, mechaniki i fizjoterapii.
Musicians’ medicine – potential health problems among violinists and violists caused by playing the string instrument – the review of the literature
Authors: Ręka Gabriela , Machowiec Piotr , Maksymowicz Marcela , Piecewicz-Szczęsna Halina 
Published: January 2022

Introduction and purpose
Musicians' medicine has received increasing attention recently. It is known that listening to music or playing an instrument has beneficial effects on cognitive and neural functions. Playing the string instrument demands repetitive precise movements of fingers and arms in a non-ergonomic posture that might give rise to health problems.
The study aims to present the current state of knowledge regarding different potential health problems among violinists and violists. The article reviews the 24 newest scientific publications available on PubMed and Google Scholar.
A brief description of the state of knowledge
The literature review indicated several potential health consequences of excessive playing the violin or viola, as follows: Fiddler's neck and skin allergy, Garrod’s pads, temporomandibular disorders, carpal tunnel syndrome, cubital tunnel syndrome, tennis elbow, compression of the right ulnar nerve in the ulnar (Guyon's) canal, rotator cuff tendonitis, tenosynovitis, bursitis, focal dystonia, thoracic outlet syndrome, bone asymmetry, pain in the neck, cheeks, fingers, wrist, forearm, shoulder, waist, and the back.
Conclusions
Musicians should be aware of potential health problems that occur during prolonged playing the violin or the viola. An important issue is maintaining the accurate proportions between the amount of time spent playing the instrument and resting. The first signs of neurological or musculoskeletal changes should prompt the musician to seek professional medical help to prevent the disorder's progression.