bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental noise exposure is associated with atherothrombotic risk
Authors: Koczorowski Magali , Bernard Nadine , Mauny Frédéric , Chagué Frederic , Pujol Sophie , Maza Maud , Cottin Yves , Zeller Marianne ,   ENVI-MI Study Group
Published: February 2022

AbstractThere is growing evidence that environmental noise exposure could increase the risk of atherothrombotic events, including acute myocardial infarction (MI). We analysed the burden of environmental noise on atherothrombotic risk in MI patients. From the RICO survey, 879 consecutive MI patients included from 2004 to 2008 and living in an urban unit of > 237,000 inhabitants were analysed. Atherothrombotic risk was calculated using the TRS-2P score. TRS-2P categories were split into low (TRS-2P = 0/1) (40.8%), medium–low (TRS-2P = 2) (25.7%), medium–high (TRS-2P = 3) (21.8%) and high risk (TRS-2P ≥ 4) (11.6%). Noise exposure was associated with atherothrombotic risk, with the LAeq,24 h(OR (95% CI): 1.165 (1.026–1.324)) and Lnight(OR (95CI): 1.157 (1.031–1.298)), for each 10 dB(A) increase. After adjustment, noise exposure remained a predictor of atherothrombotic risk, with LAeq,24 h(OR (95% CI): 1.162 (1.011–1.337)) and with Lnight(OR (95% CI): 1.159 (1.019–1.317)). The relationship with transportation Lnightwas significant for men (OR (95% CI): 1.260 (1.078–1.472)) but not for women (OR (95% CI): 0.959 (0.763–1.205)). We found a significant association between residential traffic noise exposure and atherothrombotic risk in men but not in women. These results could have major consequences for secondary prevention.
MicroRNA editing patterns in Huntington’s disease
Authors: Guo Shiyong , Yang Jun , Jiang Bingbing , Zhou Nan , Ding Hao , Zhou Guangchen , Wu Shuai , Suo Angbaji , Wu Xingwang , Xie Wenping , Li Wanran , Liu Yulong , Deng Wei , Zheng Yun 
Published: February 2022

AbstractHuntington’s disease (HD) is a neurodegenerative disease. MicroRNAs (miRNAs) are small non-coding RNAs that mediate post-transcriptional regulation of target genes. Although miRNAs are extensively edited in human brains, the editome of miRNAs in brains of HD patients is largely unknown. By analyzing the small RNA sequencing profiles of brain tissues of 28 HD patients and 83 normal controls, 1182 miRNA editing sites with significant editing levels were identified. In addition to 27 A-to-I editing sites, we identified 3 conserved C-to-U editing sites in miRNAs of HD patients. 30 SNPs in the miRNAs of HD patients were also identified. Furthermore, 129 miRNA editing events demonstrated significantly different editing levels in prefrontal cortex samples of HD patients (HD-PC) when compared to those of healthy controls. We found that hsa-mir-10b-5p was edited to have an additional cytosine at 5’-end in HD-PC, and the edited hsa-mir-10b repressed GTPBP10 that was often downregulated in HD. The down-regulation of GTPBP10 might contribute to the progression of HD by causing gradual loss of function of mitochondrial. These results provide the first endeavor to characterize the miRNA editing events in HD and their potential functions.
The decay and consolidation of effector-independent motor memories
Authors: Bao Shancheng , Wang Jinsung , Wright David L. , Buchanan John J. , Lei Yuming 
Published: February 2022

AbstractLearning a motor adaptation task produces intrinsically unstable or transient motor memories. Despite the presence of effector-independent motor memories following the learning of novel environmental dynamics, it remains largely unknown how those memory traces decay in different contexts and whether an “offline” consolidation period protects memories against decay. Here, we exploit inter-effector transfer to address these questions. We found that newly acquired motor memories formed with one effector could be partially retrieved by the untrained effector to enhance its performance when the decay occurred with the passage of time or “washout” trials on which error feedback was provided. The decay of motor memories was slower following “error-free” trials, on which errors were artificially clamped to zero or removed, compared with “washout” trials. However, effector-independent memory components were abolished following movements made in the absence of task errors, resulting in no transfer gains. The brain can stabilize motor memories during daytime wakefulness. We found that 6 h of wakeful resting increased the resistance of effector-independent memories to decay. Collectively, our results suggest that the decay of effector-independent motor memories is context-dependent, and offline processing preserves those memories against decay, leading to improvements of the subsequent inter-effector transfer.
Classification of endogenous and exogenous bursts in collective emotions based on Weibo comments during COVID-19
Authors: Wu Qianyun , Sano Yukie , Takayasu Hideki , Takayasu Misako 
Published: February 2022

AbstractBursts and collective emotion have been widely studied in social physics field where researchers use mathematical models to understand human social dynamics. However, few researches recognize and separately analyze the internal and external influence on burst behaviors. To bridge this gap, we introduce a non-parametric approach to classify an interevent time series into five scenarios: random arrival, endogenous burst, endogenous non-burst, exogenous burst and exogenous non-burst. In order to process large-scale social media data, we first segment the interevent time series into sections by detecting change points. Then we use the rule-based algorithm to classify the time series based on its distribution. To validate our model, we analyze 27.2 million COVID-19 related comments collected from Chinese social media between January to October 2020. We adopt the emotion category called Profile of Mood States which consists of six emotions:Anger,Depression,Fatigue,Vigor,TensionandConfusion. This enables us to compare the burst features of different collective emotions during the COVID-19 period. The burst detection and classification approach introduced in this paper can also be applied to analyzing other complex systems, including but not limited to social media, financial market and signal processing.
Mycorrhizal fungi arbuscular in forage grasses cultivated in Cerrado soil
Authors: dos Santos Lucas Leidiane , Neto Aurelio Rubio , de Moura Jadson Belem , de Souza Rodrigo Fernandes , Santos Maria Eduarda Fernandes , de Moura Lorena Fernandes , Xavier Elitania Gomes , dos Santos José Mateus , Nehring Ryan , Dutra e Silva Sandro 
Published: February 2022

AbstractThe Cerrado is one of the most important regions for agricultural development in the world and is the main productive breadbasket of the Americas. One of the main agricultural activities in the region is high-tech livestock. Cerrado soils are predominantly low in fertility, and arbuscular mycorrhizal fungi play a fundamental role in plant nutrition in this biome. Understanding the behavior of mycorrhizal fungi in the soil under pasture is essential for the development of more efficient and sustainable management practices. Thus, this work aims to verify the activity of arbuscular mycorrhizal fungi in different species of forage grasses cultivated in cerrado soil. To measure mycorrhizal activity, soil spore density factors and mycorrhizal colonization rates in roots of 14 forage grass genotypes were investigated. No significant differences were identified in spore density values between the investigated genotypes. Panicum maximum cv and Mombasa showed the lowest values of mycorrhizal colonization, and the highest values were found in the roots of Brachiaria decumbens. Among the identified genera associated with the rhizosphere of the genotypes studied, Gigaspora, Scutelospora and Sclerocysts are less frequent, which indicates that the association with these fungal genera is less recurrent than with the others.
Associations among autistic traits, cognitive and affective empathy, and personality traits in adults with autism spectrum disorder and no intellectual disability
Authors: Shirayama Yukihiko , Matsumoto Kazuki , Hamatani Sayo , Muneoka Katsumasa , Okada Akihiro , Sato Koichi 
Published: February 2022

AbstractReported empathy deficits in autism spectrum disorder (ASD) could be attributable to other ASD-related features. We evaluated 28 ASD adults with no intellectual disability and 24 age-matched non-ASD control subjects using the Autism-Spectrum Quotient (AQ), Questionnaire of Cognitive and Affective Empathy (QCAE), Interpersonal Reactivity Index (IRI), and NEO Personality Inventory-Revised (NEO). Compared to the controls, ASD participants showed lower scores for perspective taking, online simulation, cognitive empathy, and peripheral responsivity on the QCAE, and lower scores for perspective taking and empathic concern on the IRI. Within the ASD group, the AQ scores showed significant relationships with perspective taking, online simulation and cognitive empathy on the QCAE, and perspective taking on the IRI. The ASD group also showed higher scores for neuroticism and lower scores for extraversion on the NEO compared to the controls. However, there were no relationships between AQ scores and NEO factors within the ASD group. Multiple regression analysis with stepwise linear regression demonstrated that perspective taking score on the QCAE and extraversion score on the NEO were good predictor variables to autistic traits on the AQ. These findings help us to understand empathy and personality traits in ASD adults with no intellectual disability.
Double zero tillage and foliar phosphorus fertilization coupled with microbial inoculants enhance maize productivity and quality in a maize–wheat rotation
Authors: Harish M. N. , Choudhary Anil K. , Kumar Sandeep , Dass Anchal , Singh V. K. , Sharma V. K. , Varatharajan T. , Dhillon M. K. , Sangwan Seema , Dua V. K. , Nitesh S. D. , Bhavya M. , Sangwan S. , Prasad Shiv , Kumar Adarsh , Rajpoot S. K. , Gupta Gaurendra , Verma Prakash , Kumar Anil , George S. 
Published: February 2022

AbstractMaize is an important industrial crop where yield and quality enhancement both assume greater importance. Clean production technologies like conservation agriculture and integrated nutrient management hold the key to enhance productivity and quality besides improving soil health and environment. Hence, maize productivity and quality were assessed under a maize–wheat cropping system (MWCS) using four crop-establishment and tillage management practices [FBCT–FBCT (Flat bed–conventional tillage both in maize and wheat); RBCT–RBZT (Raised bed–CT in maize and raised bed–zero tillage in wheat); FBZT–FBZT (FBZT both in maize and wheat); PRBZT–PRBZT (Permanent raised bed–ZT both in maize and wheat], and five P-fertilization practices [P100 (100% soil applied-P); P50 + 2FSP (50% soil applied-P + 2 foliar-sprays of P through 2% DAP both in maize and wheat); P50 + PSB + AM-fungi; P50 + PSB + AMF + 2FSP; and P0 (100% NK with no-P)] in split-plot design replicated-thrice. Double zero-tilled PRBZT–PRBZT system significantly enhanced the maize grain, starch, protein and oil yield by 13.1–19% over conventional FBCT–FBCT. P50 + PSB + AMF + 2FSP, integrating soil applied-P, microbial-inoculants and foliar-P, had significantly higher grain, starch, protein and oil yield by 12.5–17.2% over P100 besides saving 34.7% fertilizer-P both in maize and on cropping-system basis. P50 + PSB + AMF + 2FSP again had significantly higher starch, lysine and tryptophan content by 4.6–10.4% over P100 due to sustained and synchronized P-bioavailability. Higher amylose content (24.1%) was observed in grains under P50 + PSB + AMF + 2FSP, a beneficial trait due to its lower glycemic-index highly required for diabetic patients, where current COVID-19 pandemic further necessitated the use of such dietary ingredients. Double zero-tilled PRBZT–PRBZT reported greater MUFA (oleic acid, 37.1%), MUFA: PUFA ratio and P/S index with 6.9% higher P/S index in corn-oil (an oil quality parameter highly required for heart-health) over RBCT-RBCT. MUFA, MUFA: PUFA ratio and P/S index were also higher under P50 + PSB + AMF + 2FSP; avowing the obvious role of foliar-P and microbial-inoculants in influencing maize fatty acid composition. Overall, double zero-tilled PRBZT–PRBZT with crop residue retention at 6 t/ha per year along with P50 + PSB + AMF + 2FSP while saving 34.7% fertilizer-P in MWCS, may prove beneficial in enhancing maize productivity and quality so as to reinforce the food and nutritional security besides boosting food, corn-oil and starch industry in south-Asia and collateral arid agro-ecologies across the globe.
TUSC2 immunogene enhances efficacy of chemo-immuno combination on KRAS/LKB1 mutant NSCLC in humanized mouse model
Authors: Meraz Ismail M. , Majidi Mourad , Shao RuPing , Meng Feng , Ha Min Jin , Shpall Elizabeth , Roth Jack A. 
Published: February 2022

AbstractKRAS/LKB1 (STK11) NSCLC metastatic tumors are intrinsically resistant to anti-PD-1 or PD-L1 immunotherapy. In this study, we use a humanized mouse model to show that while carboplatin plus pembrolizumab reduce tumor growth moderately and transiently, the addition of the tumor suppressor gene TUSC2, delivered systemically in nanovesicles, to this combination, eradicates tumors in the majority of animals. Immunoprofiling of the tumor microenvironment shows the addition of TUSC2 mediates: (a) significant infiltration of reconstituted human functional cytotoxic T cells, natural killer cells, and dendritic cells; (b) induction of antigen-specific T cell responses; (c) enrichment of functional central and memory effector T cells; and (d) decreased levels of PD-1+ T cells, myeloid-derived suppressor cells, Tregs, and M2 tumor associated macrophages. Depletion studies show the presence of functional central and memory effector T cells are required for the efficacy. TUSC2 sensitizes KRAS/LKB1 tumors to carboplatin plus pembrolizumab through modulation of the immune contexture towards a pro-immune tumor microenvironment.
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis
Authors: Hards Kiel , Cheung Chen-Yi , Waller Natalie , Adolph Cara , Keighley Laura , Tee Zhi Shean , Harold Liam K. , Menorca Ayana , Bujaroski Richard S. , Buckley Benjamin J. , Tyndall Joel D. A. , McNeil Matthew B. , Rhee Kyu Y. , Opel-Reading Helen K. , Krause Kurt , Preiss Laura , Langer Julian D. , Meier Thomas , Hasenoehrl Erik J. , Berney Michael , Kelso Michael J. , Cook Gregory M. 
Published: February 2022

AbstractIncreasing antimicrobial resistance compels the search for next-generation inhibitors with differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium tuberculosis has been clinically validated as a promising new drug target for combatting drug-resistant strains of M. tuberculosis. Here, we show that HM2-16F, a 6-substituted derivative of the FDA-approved drug amiloride, is an anti-tubercular inhibitor with bactericidal properties comparable to the FDA-approved drug bedaquiline (BDQ; Sirturo®) and inhibits the growth of bedaquiline-resistant mutants. We show that HM2-16F weakly inhibits the F1Fo-ATP synthase, depletes ATP, and affects the entry of acetyl-CoA into the Krebs cycle. HM2-16F synergizes with the cytochrome bcc-aa3 oxidase inhibitor Q203 (Telacebec) and co-administration with Q203 sterilizes in vitro cultures in 14 days. Synergy with Q203 occurs via direct inhibition of the cytochrome bd oxidase by HM2-16F. This study shows that amiloride derivatives represent a promising discovery platform for targeting energy generation in drug-resistant tuberculosis.
Type Ia SN progenitors: pre-explosion phase in nearly Chandrasekhar mass WDs
Authors: Domínguez Inma , Piersanti Luciano , Bravo Eduardo , Straniero Oscar , Cristallo Sergio 
Published: February 2022

Type Ia supernovae are used as distance indicators to measure the expansion rate of the Universe and to constrain the nature of dark energy. Current and upcoming surveys will allow to extend supernova Hubble diagrams to higher redshifts and to improve further their statistics.
It is accepted that Type Ia supernovae are thermonuclear explosions of carbon-oxygen white dwarfs in binary systems. However, the identification of their progenitors, the evolutionary path leading to the explosion and the explosion mechanism itself have not been identified yet. This is critical, as we need to understand the potential evolution of their luminosity with cosmic time and, thus, with their stellar progenitors.
We will review the current situation, considering observational hints. We will focus on our recent models, that follow the evolution of carbon-oxygen white dwarfs accreting mass up to thermonuclear runaway, and on their dependence with the initial metallicity of the white dwarf progenitors.
Compton Imaging and Machine-Learning techniques for an enhanced sensitivity in key stellar (n,γ) measurements
Authors: Lerendegui-Marco J. , Babiano-Suárez V. , Balibrea-Correa J. , Babiano-Suárez V. , Caballero L. , Calvo D. , Domingo-Pardo C. , Ladarescu I. , Real D. , Calviño F. , Casanovas A. , Tarifeño-Saldivia A. , Alcayne V. , Guerrero C. , Millán-Callado M.A. , Rodríguez-González T. , Barbagallo M. , Chiera N.M , Dressler R. , Heinitz S. , Maugeri E.A , Schumann D. , Köster U. 
Published: February 2022

Neutron capture cross-section measurements are fundamental in the study of astrophysical phenomena, such as the slow neutron capture (s-) process of nucleosynthesis operating in red-giant stars. To enhance the sensitivity of such measurements we have developed the i-TED detector. i-TED is an innovative detection system which exploits the Compton imaging technique with the aim of obtaining information about the incoming direction of the detected γ-rays. The imaging capability allows one to reject a large fraction of the dominant γ-ray background, hence enhancing the (n,γ) detection sensitivity.
This work summarizes the main results of the first experimental proof-of-concept of the background rejection with i-TED carried out at CERN n_TOF using an early i-TED demonstrator. Two state-of-the-art C6D6 detectors were also used to benchmark the performance of i-TED. The i-TED prototype built for this study shows a factor of ~3 higher detection sensitivity than C6D6 detectors in the ~10 keV neutron-energy range of astrophysical interest. This works also introduces the perspectives of further enhancement in performance attainable with the final i-TED array and new analysis methodologies based on Machine-Learning techniques. The latter provide higher (n,γ) detection efficiency and similar enhancement in the sensitivity than the analytical method based on the Compton scattering law. Finally, we present our proposal to use this detection system for the first time on key astrophysical (n,γ) measurements, in particular on the s-process branching-point 79Se, which is especially well suited to constrain the thermal conditions of Red Giant and Massive Stars.
Underground measurement at LUNA found no evidence for a low-energy resonance in the 6Li(p, γ)7Be reaction
Authors: Piatti Denise ,   for the LUNA Collaboration
Published: February 2022

The 6Li(p,γ)7Be reaction is involved in all three main nucleosynthesis scenarios: Big Bang Nucleosynthesis, the interaction of cosmic rays with interstellar matter, and stellar nucleosynthesis.
Conflicting experimental results have been reported in literature for the 6Li(p,γ)7Be reaction cross section trend at astrophysical energies. A recent direct measurement found a resonance-like structure at Ec.m. = 195 keV, corresponding to an excited state at Ex ~ 5800 keV in 7Be which, however, has not been confirmed by either theoretical calculations or other direct measurements. In order to clarify the existence of this resonance, a new experiment was performed at the Laboratory for Underground Nuclear Astrophysics, located deep underground at Laboratori Nazionali del Gran Sasso (Italy). The 6Li(p,γ)7Be cross section was measured in the energy range Ec.m. = 60-350 keV with unprecedented sensitivity and no evidence for the alleged resonance was found.
HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis
Authors: Zhao Tiejun , Wang Zhilong , Fang Jinyong , Cheng Wenzhao , Zhang Yiling , Huang Jinhua , Xu Lingling , Gou Hongwei , Zeng Linghui , Jin Zhigang , Matsuoka Masao 
Published: February 2022

Significance
The Hippo pathway plays critical roles in controlling cell proliferation, and its dysregulation is widely implicated in numerous human cancers. YAP, a Hippo signaling effector, often acts as a nexus and integrator for multiple prominent signaling networks. In this study, we discover NF-κB cross talk with the Hippo pathway and identify p65 as a critical regulator for YAP nuclear retention and transcriptional activity. Furthermore, we find that p65-induced YAP activation is essential for maintaining the proliferation of ATL cells in vitro and in vivo. Our findings unravel the functional interplay between NF-κB and YAP signaling and provide mechanistic insights into the YAP-dependent growth control pathway and tumorigenesis.
Switchable assembly and function of antibody complexes in vivo using a small molecule
Authors: Martinko Alexander J. , Simonds Erin F. , Prasad Suchitra , Ponce Alberto , Bracken Colton J. , Wei Junnian , Wang Yung-Hua , Chow Tiffany-Lynn , Huang Zhong , Evans Michael J. , Wells James A. , Hill Zachary B. 
Published: February 2022

Significance
Reported here, we describe a molecular protein technology to enable switchable assembly of functional antibody complexes. This approach, which we call ligand-induced transient engagement (LITE), allows for control of an antibody’s intended function in vivo through the dosing of a small-molecule activator. Chemical regulation of antibody therapeutics represents a treatment paradigm to provide physicians with precise control over the therapeutic activity of a biologic drug after it is administered to a patient. Ultimately, this approach may result in a new class of antibody drugs with improved efficacy and safety profiles and the potential to greatly impact the treatment of human disease.
Chinese certificate translation in the Australian context
Authors: Ko Leong 
Published: February 2022

Abstract
All countries issue certificates – marriage certificates, birth certificates, medical certificates, graduation certificates, degrees, driver’s licenses, and business permits – for various purposes, so the translation of certificates is common in the translation market. For cultural, practical, and administrative reasons, certificates issued by different countries and in different languages often take different forms and contain different information. Because translated certificates may be required for specific purposes, the appropriate translation of certificates can therefore pose challenges for translators. This paper presents a study on the translation of various certificates from Chinese into English. It attempts to compare and analyze different features of certificates in Chinese and English, identify issues encountered in the translation of certificates, and explore different translation strategies, taking into account linguistic, pragmatic, cultural, and communicative factors. Based on the findings of the data analysis, the study suggests that when translating Chinese certificates into English, it is necessary to consult the potential users of the translated certificates to identify the purposes of the translation and decide which translation strategy is appropriate.