bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congenitally corrected transposition of the great arteries outcomes of different surgical techniques in a paediatric population: A single-centre report
Authors: Di Santo Marisa , Stelmaszewski Erica V. , Dilascio Mauricio , Barreta Jorge , Garcia Delucis Pablo , Cornelis Javier , Villa Alejandra 
Published: July 2022

AbstractBackground:Congenitally corrected transposition of the great arteries is a complex pathology characterised by atrioventricular and ventriculo-arterial discordance. Optimal surgical approaches are still a matter of debate.Objective:To evaluate the outcomes of different surgical treatments in a single centre.Methods:Between 1998 and 2020, 89 patients were studied. The cohort was divided into three groups: physiologic, anatomic, and univentricular repair.Result:Physiologic correction (56.18%) was associated with significant tricuspid valve regurgitation progress (42%) and complete AV block (30%) compared to anatomic repair. Right ventricular systolic dysfunction was developed in 14%. Instead, anatomic correction (30.34%) (double switch 59% and Rastelli type 40.7%) presented moderate to severe aortic regurgitation (4%) and left ventricular systolic dysfunction (11%). Complete AV block was developed in 14.8%. Rate of reintervention was 34% for physiologic and 26% for anatomic. Univentricular palliation (13.8%) presented no complications or late mortality during the follow-up. The overall survival at 5 and 10 years, respectively, was 80% (95% CI 69, 87) and 75% (95% CI 62, 84). There was no statistically significant difference in mortality between the groups (p log-rank = 0.5752).Conclusion:Management of congenitally corrected transposition of the great arteries remains a challenge. In this cohort, outcomes after physiologic repair were satisfactory in spite of the progression of tricuspid regurgitation and the high incidence of AV block. Anatomic repair improved tricuspid regurgitation but increased the risk of aortic regurgitation and left ventricular systolic dysfunction. The Fontan group showed the lowest incidence of complications.
A pilot trial investigating the feasibility of a future randomised controlled trial of Individualised Placement and Support for people unemployed with chronic pain recruiting in primary care
Authors: Walker-Bone Karen , Fraser Simon DS , Price Cathy , Maguire Nick , Cooper Cyrus , Madan Ira , Ntani Georgia , Linaker Cathy L 
Published: July 2022

Abstract

Background:
We investigated the feasibility of recruiting patients unemployed for more than 3 months with chronic pain using a range of methods in primary care in order to conduct a pilot trial of Individual Placement and Support (IPS) to improve quality of life outcomes for people with chronic pain.

Methods:
This research was informed by people with chronic pain. We assessed the feasibility of identification and recruitment of unemployed patients; the training and support needs of employment support workers to integrate with pain services; acceptability of randomisation, retention through follow-up and appropriate outcome measures for a definitive trial. Participants randomised to IPS received integrated support from an employment support worker and a pain occupational therapist to prepare for, and take up, a work placement. Those randomised to Treatment as Usual (TAU) received a bespoke workbook, delivered at an appointment with a research nurse not trained in vocational rehabilitation.

Results:
Using a range of approaches, recruitment through primary care was difficult and resource-intensive (1028 approached to recruit 37 eligible participants). Supplementing recruitment through pain services, another 13 people were recruited (total n = 50). Randomisation to both arms was acceptable: 22 were allocated to IPS and 28 to TAU. Recruited participants were generally not ‘work ready’, particularly if recruited through pain services.

Conclusion:
A definitive randomised controlled trial is not currently feasible for recruiting through primary care in the UK. Although a trial recruiting through pain services might be possible, participants could be unrepresentative in levels of disability and associated health complexities. Retention of participants over 12 months proved challenging, and methods for reducing attrition are required. The intervention has been manualised.
Cognitive behavioural group therapy with mindfulness for kleptomania: an open trial
Authors: Asami Yuka , Nomura Kazutaka , Shimada Hironori , Nakagawa Keiko , Sugano Mayuka , Koshiba Azusa , Ohishi Yasufumi , Ohishi Hiroyo , Ohishi Masayuki 
Published: July 2022

Abstract
Kleptomania is an addiction to stealing without an economic motive; therefore, an examination of effective interventions as a preventive measure is needed. The effectiveness of cognitive behavioural therapy (CBT) combined with mindfulness for the treatment of addiction has been previously indicated, and it is presumed to be effective for kleptomania; however, this relationship remains unstudied. Therefore, this study aimed to examine the effectiveness of cognitive behavioural group therapy (CBGT) combined with mindfulness for treating kleptomania. The results of a 12-session programme of CBGT combined with mindfulness for 22 patients with kleptomania showed that kleptomania symptoms and quality of life (QOL) improved. Furthermore, the recovery process revealed that the improvement of distress tolerance affected the improvement of kleptomania symptoms and that the improvement of reward perception and distress tolerance affected the improvement of stress response and QOL. These results suggest that CBGT combined with mindfulness may be effective in improving symptoms and QOL in kleptomania.

Key learning aims

(1)
To understand the clinical features of patients suffering from kleptomania.

(2)
To learn about CBT interventions for patients with kleptomania.

(3)
To gain an increased understanding of the mechanisms of recovery in patients with kleptomania.
Deep Ocean Learning of Small Scale Turbulence
Authors: Mashayek Ali , Reynard Nick , Zhai Fangming , Srinivasan Kaushik , Jelley Adam , Naveira Garabato Alberto , Caulfield Colm‐cille P. 
Published: July 2022

AbstractTurbulent mixing at the sub‐meter scale is an essential component of the ocean's meridional overturning circulation and its associated global redistribution of heat, carbon, nutrients, pollutants, and other tracers. Whereas direct turbulence observations in the ocean interior are limited to a modest collection of field programs, basic information such as temperature, salinity, and depth is available globally. Here, we show that supervised machine learning algorithms can be trained on the existing turbulence data to develop skillful predictions of the key properties of turbulence from T, S, Z, and topographic data. This constitutes a promising first step toward a hybrid physics‐artificial intelligence approach to parameterization of turbulent mixing in ocean and climate models.
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci
Authors: Deak Joseph D. , Zhou Hang , Galimberti Marco , Levey Daniel F. , Wendt Frank R. , Sanchez-Roige Sandra , Hatoum Alexander S. , Johnson Emma C. , Nunez Yaira Z. , Demontis Ditte , Børglum Anders D. , Rajagopal Veera M. , Jennings Mariela V. , Kember Rachel L. , Justice Amy C. , Edenberg Howard J. , Agrawal Arpana , Polimanti Renato , Kranzler Henry R. , Gelernter Joel 
Published: July 2022

AbstractDespite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of OUD in individuals of European (EUR) and African (AFR) ancestry, optimizing genetic informativeness by performing MTAG (Multi-trait analysis of GWAS) with genetically correlated substance use disorders (SUDs). Meta-analysis included seven cohorts: the Million Veteran Program, Psychiatric Genomics Consortium, iPSYCH, FinnGen, Partners Biobank, BioVU, and Yale-Penn 3, resulting in a total N = 639,063 (Ncases = 20,686;Neffective = 77,026) across ancestries. OUD cases were defined as having a lifetime OUD diagnosis, and controls as anyone not known to meet OUD criteria. We estimated SNP-heritability (h2SNP) and genetic correlations (rg). Based on genetic correlation, we performed MTAG on OUD, alcohol use disorder (AUD), and cannabis use disorder (CanUD). A leave-one-out polygenic risk score (PRS) analysis was performed to compare OUD and OUD-MTAG PRS as predictors of OUD case status in Yale-Penn 3. The EUR meta-analysis identified three genome-wide significant (GWS; p ≤ 5 × 10−8) lead SNPs—one at FURIN (rs11372849; p = 9.54 × 10−10) and two OPRM1 variants (rs1799971, p = 4.92 × 10−09; rs79704991, p = 1.11 × 10−08; r2 = 0.02). Rs1799971 (p = 4.91 × 10−08) and another OPRM1 variant (rs9478500; p = 1.95 × 10−08; r2 = 0.03) were identified in the cross-ancestry meta-analysis. Estimated h2SNP was 12.75%, with strong rg with CanUD (rg = 0.82; p = 1.14 × 10−47) and AUD (rg = 0.77; p = 6.36 × 10−78). The OUD-MTAG resulted in a GWAS Nequivalent = 128,748 and 18 independent GWS loci, some mapping to genes or gene regions that have previously been associated with psychiatric or addiction phenotypes. The OUD-MTAG PRS accounted for 3.81% of OUD variance (beta = 0.61;s.e. = 0.066; p = 2.00 × 10−16) compared to 2.41% (beta = 0.45; s.e. = 0.058; p = 2.90 × 10−13) explained by the OUD PRS. The current study identified OUD variant associations at OPRM1, single variant associations with FURIN, and 18 GWS associations in the OUD-MTAG. The genetic architecture of OUD is likely influenced by both OUD-specific loci and loci shared across SUDs.
A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice
Authors: Strohmeier Shirin , Amanat Fatima , Campbell John D. , Traquina Paula , Coffman Robert L. , Krammer Florian 
Published: July 2022

AbstractInfluenza virus infections pose a significant threat to global health. Vaccination is the main countermeasure against influenza virus spread, however, the effectiveness of vaccines is variable. Current seasonal influenza virus vaccines mostly rely on the immunodominant hemagglutinin (HA) glycoprotein on the viral surface, which usually leads to a narrow and strain-specific immune response. The HA undergoes constant antigenic drift, which can lead to a dramatic loss in vaccine effectiveness, requiring the annual reformulation and readministration of influenza virus vaccines. Recently, it has been demonstrated that the subdominant glycoprotein, neuraminidase (NA), is an attractive target for vaccine development. Here, we tested a newly developed recombinant influenza virus N1 neuraminidase vaccine candidate, named N1-MPP, adjuvanted with CpG 1018, a TLR9 agonist. Additionally, N2-MPP and B-NA-MPP vaccine constructs have been generated to cover the range of influenza viruses that are seasonally circulating in humans. These constructs have been characterized in vitro and in vivo regarding their functionality and protective potential. Furthermore, a trivalent NA-MPP mix was tested. No antigenic competition between the individual NA constructs was detected. By adjuvating the recombinant protein constructs with CpG 1018 it was possible to induce a strong and robust immune response against the NA, which provided full protection against morbidity and mortality after high lethal challenges in vivo. This study provides important insights for the development of a broadly protective NA-based influenza virus vaccine candidate.
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice
Authors: Tolani Bhairavi , Celli Anna , Yao Yanmin , Tan Yong Zi , Fetter Richard , Liem Christina R. , de Smith Adam J. , Vasanthakumar Thamiya , Bisignano Paola , Cotton Adam D. , Seiple Ian B. , Rubinstein John L. , Jost Marco , Weissman Jonathan S. 
Published: July 2022

AbstractMutations in Ras family proteins are implicated in 33% of human cancers, but direct pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct inhibition, we screened for sensitivities in Ras-mutant cells and discovered 249C as a Ras-mutant selective cytotoxic agent with nanomolar potency against a spectrum of Ras-mutant cancers. 249C binds to vacuolar (V)-ATPase with nanomolar affinity and inhibits its activity, preventing lysosomal acidification and inhibiting autophagy and macropinocytosis pathways that several Ras-driven cancers rely on for survival. Unexpectedly, potency of 249C varies with the identity of the Ras driver mutation, with the highest potency forKRASG13D and G12V both in vitro and in vivo, highlighting a mutant-specific dependence on macropinocytosis and lysosomal pH. Indeed, 249C potently inhibits tumor growth without adverse side effects in mouse xenografts ofKRAS-driven lung and colon cancers. A comparison of isogenic SW48 xenografts with differentKRASmutations confirmed thatKRASG13D/+ (followed by G12V/+) mutations are especially sensitive to 249C treatment. These data establish proof-of-concept for targeting V-ATPase in cancers driven by specificKRASmutations such asKRASG13D and G12V.
Na+ riboswitches regulate genes for diverse physiological processes in bacteria
Authors: White Neil , Sadeeshkumar Harini , Sun Anna , Sudarsan Narasimhan , Breaker Ronald R. 
Published: July 2022

AbstractOrganisms presumably have mechanisms to monitor and physiologically adapt to changes in cellular Na+ concentrations. Only a single bacterial protein has previously been demonstrated to selectively sense Na+ and regulate gene expression. Here we report a riboswitch class, previously called the ‘DUF1646 motif’, whose members selectively sense Na+ and regulate the expression of genes relevant to sodium biology. Many proteins encoded by Na+-riboswitch-regulated genes are annotated as metal ion transporters, whereas others are involved in mitigating osmotic stress or harnessing Na+ gradients for ATP production. Na+ riboswitches exhibit dissociation constants in the low mM range, and strongly reject all other alkali and alkaline earth ions. Likewise, only Na+ triggers riboswitch-mediated transcription and gene expression changes. These findings reveal that some bacteria use Na+ riboswitches to monitor, adjust and exploit Na+ concentrations and gradients, and in some instances collaborate with c-di-AMP riboswitches to coordinate gene expression during osmotic stress.
Machine learning-based analysis of overall stability constants of metal–ligand complexes
Authors: Kanahashi Kaito , Urushihara Makoto , Yamaguchi Kenji 
Published: July 2022

AbstractThe stability constants of metal(M)-ligand(L) complexes are industrially important because they affect the quality of the plating film and the efficiency of metal separation. Thus, it is desirable to develop an effective screening method for promising ligands. Although there have been several machine-learning approaches for predicting stability constants, most of them focus only on the first overall stability constant of M-L complexes, and the variety of cations is also limited to less than 20. In this study, two Gaussian process regression models are developed to predict the first overall stability constant and the n-th (n > 1) overall stability constants. Furthermore, the feature relevance is quantitatively evaluated via sensitivity analysis. As a result, the electronegativities of both metal and ligand are found to be the most important factor for predicting the first overall stability constant. Interestingly, the predicted value of the first overall stability constant shows the highest correlation with the n-th overall stability constant of the corresponding M-L pair. Finally, the number of features is optimized using validation data where the ligands are not included in the training data, which indicates high generalizability. This study provides valuable insights and may help accelerate molecular screening and design for various applications.
An inertial mechanism behind dynamic station holding by fish swinging in a vortex street
Authors: Harvey Sam Tucker , Muhawenimana Valentine , Müller Stephanie , Wilson Catherine A. M. E. , Denissenko Petr 
Published: July 2022

AbstractMany aquatic and aerial animal species are known to utilise their surrounding flow field and/or the induced flow field of a neighbour to reduce their physical exertion, however, the mechanism by which such benefits are obtained has remained elusive. In this work, we investigate the swimming dynamics of rainbow trout in the wake of a thrust-producing oscillating hydrofoil. Despite the higher flow velocities in the inner region of the vortex street, some fish maintain position in this region, while exhibiting an altered swimming gait. Estimates of energy expenditure indicate a reduction in the propulsive cost when compared to regular swimming. By examining the accelerations of the fish, an explanation of the mechanism by which energy is harvested from the vortices is proposed. Similar to dynamic soaring employed by albatross, the mechanism can be linked to the non-equilibrium hydrodynamic forces produced when fish encounter the cross-flow velocity generated by the vortex street.
Reflection of vortex beam from relativistic flying mirror
Authors: Chen Weixin , Zhang Xiaomei , Xu Dirui , Guo Xinju , Shen Baifei 
Published: July 2022

AbstractIn this study, the change in the angular momentum of a vortex beam after reflection from a relativistic flying mirror is investigated. This change is determined by performing full three-dimensional particle-in-cell simulations. The results confirm that the spin angular momentum and linear momentum carried by the reflected beam are collinear. In addition, we show that the orbital angular momentum is not collinear with the linear momentum carried by the reflected beam owing to the Doppler effect.
Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness
Authors: Joo Jaehyun , Mak Angel C. Y. , Xiao Shujie , Sleiman Patrick M. , Hu Donglei , Huntsman Scott , Eng Celeste , Kan Mengyuan , Diwakar Avantika R. , Lasky-Su Jessica A. , Weiss Scott T. , Sordillo Joanne E. , Wu Ann C. , Cloutier Michelle , Canino Glorisa , Forno Erick , Celedón Juan C. , Seibold Max A. , Hakonarson Hakon , Williams L. Keoki , Burchard Esteban G. , Himes Blanca E. 
Published: July 2022

AbstractVariability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator response (BDR) to identify potential mechanisms of drug response and risk factors for worse asthma outcomes. Genome-wide association studies of bronchodilator response (BDR) were performed using TOPMed Whole Genome Sequencing data of the Asthma Translational Genomic Collaboration (ATGC), which corresponded to 1136 Puerto Rican, 656 Mexican and 4337 African American patients with asthma. With the population-specific GWAS results, a trans-ethnic meta-analysis was performed to identify BDR-associated variants shared across the three populations. Replication analysis was carried out in three pediatric asthma cohorts, including CAMP (Childhood Asthma Management Program; n = 560), GACRS (Genetics of Asthma in Costa Rica Study; n = 967) and HPR (Hartford-Puerto Rico; n = 417). A genome-wide significant locus (rs35661809; P = 3.61 × 10–8) in LINC02220, a non-coding RNA gene, was identified in Puerto Ricans. While this region was devoid of protein-coding genes, capture Hi-C data showed a distal interaction with the promoter of the DNAH5 gene in lung tissue. In replication analysis, the GACRS cohort yielded a nominal association (1-tailed P < 0.05). No genetic variant was associated with BDR at the genome-wide significant threshold in Mexicans and African Americans. Our findings help inform genetic underpinnings of BDR for understudied minority patients with asthma, but the limited availability of genetic data for racial/ethnic minority children with asthma remains a paramount challenge.
Adsorption, thermodynamic, and quantum chemical investigations of an ionic liquid that inhibits corrosion of carbon steel in chloride solutions
Authors: Abbas Mohamed A. , Ismail Amr S. , Zakaria K. , El-Shamy A. M. , El Abedin S. Zein 
Published: July 2022

AbstractThe purpose of this work lies in the use of ionic liquids as corrosion inhibitors due to the difficulty in some oil fields with the solubility of corrosion inhibitors and these materials can be miscible with water and thus provide a solution to such problems in the industry. The second purpose is concerned with the lower toxicity of these compounds compared with the most common corrosion inhibitors. The study covered the corrosion inhibition performance of the ionic liquid 1-butyl-3-methylimidazolium trifluoromethyl sulfonate ([BMIm]TfO) for carbon steel in 3.5% NaCl solutions. The study comprised electrochemical, adsorption, and quantum chemical investigations. The results manifested that [BMIm]TfO can be considered a promising corrosion inhibitor and the inhibition efficacy intensifies as the concentration rises. The observed inhibitive effect can be correlated to the adsorption of the ionic liquid species and the creation of protecting films on the surface. The mode of adsorption follows the Langmuir adsorption isotherm. The polarization results showed that the ionic liquid [BMIm]TfO functions as a mixed inhibitor. Reliance of the corrosion influence on the temperature in the existence and absence of [BMIm]TfO was demonstrated in the temperature range of 303–333 K using polarization data. Activation parameters were determined and discussed. The observed inhibition performance of [BMIm]TfO was correlated with the electronic properties of the ionic liquid using a quantum chemical study.
Role of mineral nutrients, antioxidants, osmotic adjustment and PSII stability in salt tolerance of contrasting wheat genotypes
Authors: Hussain Nadeem , Sohail Younas , Shakeel Nasir , Javed Muhammad , Bano Hussan , Gul Hafiza Saima , Zafar Zafar Ullah , Frahat Zaky Hassan Islam , Ghaffar Abdul , Athar Habib-ur-Rehman , Ajaj Rahaf 
Published: July 2022

AbstractGlobal food production is threatened due to increasing salinity and can be stabilized by improving salt tolerance of crops. In the current study, salt tolerance potential of 40 local wheat cultivars against 150 mM NaCl stress was explored. Salt treatment at seedling stage caused less reduction in biomass, K+ and P while more decline of Na+ in tolerant cultivars due to reduced translocation and enhanced exclusion of Na+ from leaves. Principal component analysis based selected S-24, LU-26S, Pasban-90 (salt tolerant) and MH-97, Kohistan-97, Inqilab-91 and Iqbal-2000 (salt sensitive) cultivars were evaluated at adult stage applying 150 mM salinity. Osmotic adjustment by accumulation of soluble sugars and proline and accelerated antioxidant enzymes activities caused efficient scavenging of reactive oxygen species making S-24 and LU-26S tolerant while in MH-97 and Kohistan-97, high MDA represent greater membrane damage due to oxidative stress making them salt sensitive. Chlorophyll a fluorescence transients confirmed better efficiency of photosystem II in S-24 and LU-26S based on energy fluxes (ABS/RC, TRo/RC, ETo/RC and DIo/RC), performance index (PIABS) and maximum quantum yield (Fv/Fm). These findings can be correlated using molecular techniques to identify genes for salt exclusion, osmotic adjustment and photosynthetic activity for use in molecular breeding programs.