bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transformation mechanism of ofloxacin (OFL) by chlorine dioxide disinfection in water distribution system: kinetics, byproducts and toxicity
Authors: Chen Peng , Hu Shaowei , Ma Guangyu , Wang Fei , Liu Fang , Wang Yong , He Guilin 
Published: August 2022

Abstract
There is a research gap on the transformation of ofloxacin (OFL) in water supply systems under the action of ClO2. The degradation kinetics of OFL under different ClO2 concentrations, pH and pipe materials, and formation of intermediates, as well as the toxicity of water in water supply systems were first studied. The results showed that the degradation of OFL in PE pipe and deionized water increased with the increase of ClO2 concentration, and the reaction of OFL followed the second-order kinetic model. The removal rate of OFL in deionized water was faster than that in PE pipe. The degradation rate of OFL in PE tube and deionized water were positively correlated with pH. In addition, degradation efficiency of OFL in different pipes followed: cast iron pipe &gt; stainless steel pipe &gt; PE pipe. The detection of OFL intermediates showed that the cleavage of piperazine groups were the main and initial products in the degradation process of OFL. In addition, the decarboxylation intermediates of quinolone groups were also detected. The aquatic toxicity test showed that the degradation of OFL by ClO2 would increase the toxicity of water, therefore, the decrease of OFL may not mean the decrease of water toxicity.
Nickel removal from aqueous solutions using flow-electrode capacitive deionization (Optimization by Response Surface Methodology (RSM))
Authors: Pelarti Mahdieh Mohammadi , Mirbagheri Seyed Ahmad , Dehghan Khadijeh , Alam Mahdi 
Published: August 2022

Abstract
Nowadays, wastewater and water treatment with an efficient system for the removal of heavy metals is a serious challenge. Nickel is one of the main heavy metal pollutants that exist in the wastewater of various industries. Several technologies have been developed for removal of nickel, including the new electrochemical processes. In this experimental study, nickel removal by flow-electrode capacitative deionization (FCDI) in batch-mode is investigated. FCDI experiments with water-fed nickel concentrations of 10, 25, and 40 mg/l, input water pH of 5, 6, and 7, and sodium chloride content of 0, 0.1, and 0.2 M in the flow electrode was investigated to achieve the highest nickel removal rate. Finally, the data were analyzed by response surface methodology (RSM). Accordingly, the best nickel removal performance of the system was achieved at pH of about 6.2, electrolyte NaCl concentration of 0.13 M, and input nickel concentration of 10 mg/l.
Irisin Relaxes Rat Trachea via KV Channels, KATP Channels, and BKCa
Channels
Authors: Demirel Sadettin , Ozyener Fadil 
Published: August 2022

Background/Objective:
This study aimed to investigate the effects of irisin on rat
tracheal smooth muscle contraction-relaxation responses and the roles of voltage-gated potassium
(KV) channels, ATP-sensitive potassium (KATP) channels, and large-conductance calcium-activated
potassium (BKCa) channels in these effects.

Methods:
Isometric contraction and relaxation responses of tracheal segments were measured using
the tissue bath method. Submaximal contractions were induced by ACh (10-5 M) or KCl (60 mM),
and then concentration-response curves of irisin (10-9 to 10-6 M) were obtained. For the temporal
control, a double-distilled water group was formed. ACh and irisin were added to the baths after
tracheal segments were incubated with 4-AP (KV channel blocker), glibenclamide (KATP channel
blocker), TEA, and iberiotoxin (BKCa channel blockers) to assess the role of K+ channels. In
addition, a vehicle group was performed for the solvent dimethyl sulfoxide (DMSO).

Results:
Irisin exhibited the relaxant effects in tracheal segments precontracted with both ACh and
KCl at concentrations of 10-8-10-6 M (p<0.05). Besides, incubations of 4-AP, glibenclamide, TEA,
and iberiotoxin significantly inhibited the irisin-mediated relaxation (p<0.05), whereas DMSO
incubation did not modulate irisin responses (p>0.05).

Conclusion:
In conclusion, the first physiological results on the relaxant effects of irisin in rat
trachea were obtained. Our findings demonstrated that irisin mediates concentration-dependent
relaxation in rat tracheas. Moreover, the present study reported for the first time that irisin-induced
bronchorelaxation is associated with the activity of the K+ channels.
Repurposing Metformin for Vascular Disease
Authors: Triggle Chris R. , Marei Isra , Ye Kevin , Ding Hong , Anderson Todd J. , Hollenberg Morley D. , Hill Michael A. 
Published: August 2022

Abstract:
Metformin has been used as an oral anti-hyperglycaemic drug since the late
1950s; however, following the release in 1998 of the findings of the 20-year United Kingdom
Prospective Diabetes Study (UKPDS), metformin use rapidly increased and today is
the first-choice anti-hyperglycaemic drug for patients with type 2 diabetes (T2D). Metformin
is in daily use by an estimated 150 million people worldwide. Historically, the benefits
of metformin as an anti-diabetic and cardiovascular-protective drug have been linked
to effects in the liver, where it acts to inhibit gluconeogenesis and lipogenesis, as well as
reduce insulin resistance and enhance peripheral glucose utilization. However, direct protective
effects on the endothelium and effects in the gut prior to metformin absorption are
now recognized as important. In the gut, metformin modulates the glucagon-like peptide-
1 (GLP-1) - gut-brain axis and impacts the intestinal microbiota. As the apparent
number of putative tissue and cellular targets for metformin has increased, so has the interest
in re-purposing metformin to treat other diseases that include polycystic ovary syndrome
(PCOS), cancer, neurodegenerative diseases, and COVID-19. Metformin is also
being investigated as an anti-ageing drug. Of particular interest is whether metformin provides
the same level of vascular protection in individuals other than those with T2D, including
obese individuals with metabolic syndrome, or in the setting of vascular thromboinflammation
caused by SARS-CoV-2. In this review, we critically evaluate the literature
to highlight clinical settings in which metformin might be therapeutically repurposed
for the prevention and treatment of vascular disease.
Iron Oxide Nano Particles and its Applications to Cure HER2-Positive
Mediated Breast Cancer
Authors: Singh Dilpreet , Kurmi Balak Das , Sarma G.S. , Bhattacharya Sankha , Nagdev Sanjay 
Published: August 2022

Background:
Breast cancer is the second leading cause of death in women worldwide. The extremely rapid rate of metastasis and the propensity to develop resistance to all non-traditional treatments make them equally difficult to treat, which are the causes of increased morbidity and death in breast melanoma patients. Experts all around the world have been focusing on the first detection of a breast lump so that action can be taken at the earliest possible time. Furthermore, traditional treatment procedures such as chemotherapy, radiation, and local surgical treatment suffer from a slew of drawbacks, including toxicity, normal cell genetic modification, and cancer cell spread to healthy tissues. As a result, new therapy regimens with little toxicity to normal cells must be developed very away.

Methods:
Iron oxide nanoparticles are still widely utilized for heat targeting and imaging of breast development cells. Using an external magnetic field, they can be coupled with medicines, proteins, enzymes, antibodies, or nucleotides and delivered to target organs, tissues, or malignancies.

Results:
Both in vitro and in vivo, iron oxide nanoparticles have been found to be effective as theranostics treating breast cancer. Furthermore, their interactions with pharmaceuticals or functional biomolecules improve drug delivery efficiency and reduce drug systemic toxicity.

Conclusion:
The multipurpose presentations of superparamagnetic iron oxide nanoparticles on the analysis, behavior, and perceiving development of breast disease remedy are emphasized in this assessment. Because of their remarkable superparamagnetic, biocompatible, and biodegradable qualities, they are widely used.
Caracterización anatomopatológica de neumonías en cuyes producidas por Streptococcus pneumoniae en crianza intensiva
Authors: Villanueva-Guzmán Betty , Ramírez-Marina Rosario , Morales Cauti Siever 
Published: August 2022

Objetivo. Caracterizar macroscópica y microscópicamente las lesiones causadas por Streptococcus pneumoniae en muestras de pulmón de cuyes (Cavia porcellus) de crianza intensiva de Lima. Materiales y métodos. Se hizo la necropsia de 138 cuyes con signos clínicos de neumonía, y se tomó la muestra de los pulmones afectados. Se realizó el aislamiento bacteriano para la identificación de Streptococcus pneumoniae, utilizando agar sangre y pruebas bioquímicas; se realizó el procesamiento histopatológico utilizando la coloración hematoxilina eosina (HE) de las muestras de tejidos conservados en formol al 10%. Resultados. Del total de los pulmones diagnosticados con neumonía en necropsia, el 17.4 % (24/138) resultó positivo a Streptococcus pneumoniae; De estos, el 75% (18/24) mostró características macroscópicas de neumonía intersticial/Neumonía broncointersticial y 25% (6/24) características macroscópicas de bronconeumonía. En la evaluación microscópica se encontró que el 37.5% presentó tanto para neumonía intersticial y neumonía broncointersticial, y un 25% de ellas corresponden a bronconeumonía. Conclusión. la neumonía intersticial, neumonía broncointersticial y bronconeumonía con diagnóstico de Streptococcus pneumoniae son patrones lesionales encontradas en sistemas de crianza intensiva de Lima.
Potencialidades del consorcio microbiano Curvularia kusanoi -Trichoderma pleuroticola como pretratamiento biológico para la degradación de fuentes fibrosas
Authors: Alberto-Vazquez Maryen , Valiño-Cabreras Elaine C. , Torta Livio , Laudicina Vito Armando , Sardina Maria Teresa , Mirabile Giulia 
Published: August 2022

Objetivo. Evaluar la potencialidad del consorcio microbiano Curvularia kusanoi L7- Trichoderma pleuroticola como método biológico de pretratamiento de alimentos altos en fibra destinados a la producción animal. Materiales y métodos. Se utilizaron las cepas Curvularia kusanoi L7 y Trichoderma pleuroticola. Se evaluó el potencial degradativo a través de las cinéticas de producción de las enzimas celulolítica (endo-1,4-β- glucanasa y exo-1,4-β- glucanasa) y ligninolíticas (lacasa y peroxidasa) en fermentación sólido sumergido de salvado de trigo y de bagazo de caña de azúcar. Se analizó el crecimiento del cocultivo en placas. Se determinó el efecto del consorcio sobre la mineralización del carbono de la paja de trigo cruda y se evaluó el grado de degradación de la fibra por espectroscopía infrarroja (IR). Resultados. Ambas cepas mostraron alta producción celulolítica . Solo C. kusanoi L7 mostró actividad ligninolítica, con actividad lacasa máxima de 1400 U/L. No se encontró antagonismo entre las cepas y los resultados de mineralización del carbono y evaluación de sus productos finales mediante IR, indican la efectividad del consorcio para degradar la pared celular de forma más eficiente que cada una de las cepas de manera individual. Conclusiones. Se concluye que el consorcio microbiano C. kusanoi L7-T.pleuroticola presenta grandes potencialidades para emplearse en la modificación estructural de fuentes fibrosas destinadas a la alimentación animal.
Aspek Seksualitas pada Pasien dengan Kanker Serviks
Authors: Subagya Ami Novianti , Udiani Ni Nyoman , Firdaus Suci Amalia 
Published: August 2022

Background: Sexuality is an important aspect of life. Cancer and its treatment not only affect the physical and psychological wellbeing of patients but also can affect their sexual health.Objective: The objective of this review is to conduct a review of the literature regarding sexuality in cervical cancer patients, after taking into consideration the principal changes produced by the disease and its treatment.Method: This review considered references through a search of PubMed by use of the search terms “cervical cancer patients,” “therapy OR treatment,” in combination with “sexuality.”Result: patients with cervical cancer mostly experience sexual problems, such as decreased interest and sexual activity, pain during intercourse, difficulty reaching orgasm, lack of lubrication, dyspareunia and vaginal shortness. Treatment with surgery, chemotherapy, radiotherapy, are factors that can affect sexuality and quality of life in patients with cancer.Conclusion: Several sexuality problems found among majority of cervical cancer patients. The presence of sexual dysfunction in cervical cancer is caused by the disease and its treatment. Cervical cancer patients need nursing care intervention in sexuality aspect. ABSTRAKLatar Belakang: Seksualitas merupakan aspek penting dalam kehidupan. Kanker beserta pengobatannya tidak hanya berdampak pada kesejahteraan fisik dan psikologis pasien, namun juga dapat memengaruhi kesejahteraan seksualitas seorang individu.Tujuan: Tinjauan literatur ini bertujuan untuk melihat aspek seksualitas pada pasien kanker serviks, berdasarkan perubahan utama yang disebabkan oleh penyakit dan pengobatannya.Metode: pencarian literatur dilakukan pada 3 database yaitu PubMed, Science Direct dan Cochrane, menggunakan istilah pencarian “cervical cancer patients,” “therapy OR treatment,” dan "sexuality." Diperoleh sebanyak 7 orisinal artikel yang berkaitan dengan aspek seksualitas pada pasien dengan kanker serviks dalam Bahasa Inggris pada kurun tahun 2014 – 2019.Hasil: Pasien dengan kanker serviks sebagian besar mengalami masalah seksualitas, antara lain penurunan minat dan aktivitas seksual, rasa sakit selama hubungan seksual, kesulitan untuk mencapai orgasme, kurangnya lubrikasi, dyspareunia, serta vaginal shortness. Pengobatan dengan pembedahan, kemoterapi, terapi hormon, radioterapi, dan obat-obatan menjadi faktor yang dapat memengaruhi seksualitas pada pasien dengan kanker.Kesimpulan: Berbagai masalah seksualitas ditemukan pada sebagian besar pasien dengan kanker serviks. Adanya gangguan seksual pada pasien dengan kanker serviks disebabkan oleh penyakit dan pengobatannya. Diperlukan intervensi perawatan aspek seksualitas pada pasien kanker serviks.
Java Sparrow <i>Lonchura oryzivora</i> at Bali Barat National Park: Do They Still Persist?
Authors: Yuni Luh Putu Eswaryanti Kusuma , Wijaya I Made Saka , Untung Mas , Widiyavedanta Gde Oka , Congdenjit Egmont , Yuda Pramana 
Published: August 2022

The main purpose of the establishment Bali Barat National Park was to conserve the endemic endangered Bali Starling. However, based on data on 2004, one endangered species, Java Sparrow Lonchura oryzivora also resided in there. Current official report of sighting is ultimately required since it acts as reference in the management of a conservation area. We reported four sightings of Java Sparrow flocks occurred in June, 2021 at the Prapat Agung Peninsula, 28 individuals in total consisted of 13 adults and 15 juveniles, in a transition area of monsoon forest and savannah. The biggest flock sighted was eleven individuals. This study therefore confirmed that the Java Sparrow was still persisted at the Bali Barat National Park in 2021, in Prapat Agung Peninsula in particular.
Adaptación del Parenting Stress Index-4 Short Form en Madres Mexicanas de Preescolares
Authors: Hernández Trejo Laura Amada , Lucio Gómez-Maqueo María Emilia , Vega Pérez Lizbeth Obdulia 
Published: August 2022

La escala Parenting Stress Index-4-Short Form (PSI-4-SF) es uno de los instrumentos más utilizados en la medición del estrés parental en el ámbito de la investigación sobre este tema. El propósito de este estudio fue analizar la estructura factorial y confiabilidad de una versión traducida y adaptada a la población mexicana. Los reactivos de la prueba fueron traducidos y adaptados al español, utilizando el procedimiento estándar de traducción y retraducción. Participaron voluntariamente 332 mujeres entre 18 y 51 años de edad (M=34.27 D.E.=7.34) que cumplieron los criterios de inclusión; quienes contestaron individualmente la escala en línea. Mediante Análisis Factorial Exploratorio, emergieron dos factores que explicaron el 50.26% de la varianza (KMO=.848): Factor I Distrés parental (33.26% de la varianza explicada, α ordinal= .822) y Factor II Malestar por el cuidado de los hijos (17% de la varianza explicada, α ordinal= .869). En esta adaptación solo se conservaron 20 de los 36 reactivos que constituyen la escala original. Con lo obtenido se plantea la posibilidad de una medición eficaz del estrés parental en madres de preescolares en población mexicana, lo que permite continuar con esta línea de investigación.
‘Ibadurrahman dalam Perpekstif Al-Qur’an: Studi Hermeneutics/Tafsir Maudhu’i
Authors: Suhemi Emi 
Published: August 2022

‘Ibadurrahman is an expression in Arabic which consists of 2 words, namely Ibad and arrahman. Ibad means servant, in the Qur'an it is usually indicated for those who believe, those who obey the commands of Allah and His Messenger. While arrahman means the most merciful. So, ‘Ibadurrahman is a servant of Allah who was given honor by Allah as a most merciful servant. This research is entitled ‘Ibadurrahman in the perspective of the Koran Al-Quran by using a hermeneutics approach (tafsir maudhu'i). The steps taken in this approach are collecting verses with the theme of ‘Ibadurrahman in the Al-Quran, then also collecting hadiths on the theme of ‘Ibadurrahman criteria, and also using several dictionaries which are used as tools to find an etymological understanding of Ibadurrahman's criteria. The purpose of this research is to know the criteria of Ibadurrahman in the Al-Quran. The result of this research is that it is found that there are ten criteria from ‘Ibadurrahman.ABSTRAK‘Ibadurrahman adalah ungkapan dalam bahasa Arab yang terdiri dari 2 kata yaitu Ibad dan ar-Rahman. Ibad artinya hamba, dalam al-Qur'an biasa ditunjukkan untuk orang-orang yang beriman, orang-orang yang ta'at kepada perintah Allah dan Rasul-Nya. Sedangkan ar-Rahman artinya yang maha pengasih. Jadi, ‘Ibadurrahman adalah hamba Allah yang diberi kemulian oleh Allah sebagai hamba yang maha penyayang. Penelitian ini berjudul ‘Ibadurrahman dalam Perspektif Al-Quran penelitian ini menggunakan pendekatan hermeneutics (tafsir maudhu’i). Adapun langkah-langkah yang ditempuh dalam pendekatan ini yaitu mengumpulkan ayat-ayat yang bertemakan ‘Ibadurrahman di dalam al-Qur’an, kemudian juga mengumpulkan hadist-hadist yang bertemakan kriteria ‘Ibadurrahman, dan juga menggunakan beberapa kamus yang dijadikan alat untuk menemukan pemahaman kriteria ‘Ibadurrahman secara etimologi. Adapun tujuan dari penelitian ini adalah mengetahui kriteria ‘Ibadurrahman dari sudut pandang penafsiran al-Qur’an. Hasil dari penelitian ini adalah ditemukan pemahaman yang bervariasi tentang penafsiran dari kriteria ‘Ibadurrahman.
Konstruksi Pemikiran Moderasi Beragama Perspektif Hermeneutika Hadis
Authors: Sabri Muhammad 
Published: August 2022

The conflict of religion is fundamentally caused by understanding and perception. This paper aims to build objectivity of thinking in understanding hadith, so as not to fall into a radical and liberal understanding. With this, the researcher explores the hermeneutics of hadith as construction in religious moderation thinking. This study uses a descriptive qualitative approach. By taking reference sources from books, and scientific articles related to hadith hermeneutics using Google Sholar and other websites. The data analysis technique is reading, critically analyzing and drawing conclusions. The findings in this study show that hadith hermeneutics can be positioned as a construct of religious moderation thinking because in hadith hermeneutics there is critical thinking, comprehensive thinking and comparative thinking. These three thoughts are the urgency in understanding the arguments in the midst of religious communities, between religions and nations. ABSTRAKKonflik suatu agama secara fundamental disebabkan oleh pemahaman dan persepsi. Tulisan ini bertujuan membangun objektivitas berpikir dalam memahami hadis, agar tidak terjerumus kepada pemahaman radikal dan liberal. Dengan ini, peneliti mengeksplorasi hermeneutika hadis sebagai konstruksi dalam pemikiran moderasi beragama. Penelitian ini menggunakan pendekatan Kualitatif deskriptif. Dengan mengambil sumber referensi dari buku, artikel ilmiah yang berkaitan dengan hermeneutika hadis dengan menggunakan Google Sholar dan web lainnya. Teknik analis data yakni, adalah membaca, menganalisis secara kritis dan menarik kesimpulan. Adapun hasil temuan pada penelitian ini, bahwa hermeneutika hadis bisa diposisikan sebagai konstruksi pemikiran moderasi beragama, karena dalam hermeneutika hadis terdapat berpikir kritis, berpikir secara komprehensif dan berpikir secara komparatif. Tiga pemikiran ini adalah urgensi dalam memahami dalil di tengah umat beragama, antar agama dan bangsa.
A palavra na literatura e em outras artes
Authors: Ferreira Dias Ana Rosa , Vecchia da Rocha e Silva Rejane 
Published: August 2022

O presente número da Revista FronteiraZ traz um dossiê de artigos reunidos sob a temática A palavra na literatura e em outras artes. A literatura, como repositório das experiências humanas vividas e imaginadas, potencializa a palavra dando-lhe corporeidade. Matéria prima dos diálogos, produzidos com propósitos estéticos, aproxima-se da expressividade natural da fala e se abre a diferentes contextos de práticas interacionais. A palavra escrita, lida, vocalizada, ouvida é franqueada às diversas artes. Nas Artes Cênicas, ganha as dimensões do próprio corpo, de seu saber sensível, no trabalho do ator em seu processo de composição poética da voz. Em Artes outras, para além das literárias e performáticas, a palavra compõe visualidades e demarca sua expansão para os mais amplos territórios de manifestação estética.
Os artigos que FronteiraZ acolhe neste número flagram a expressividade da palavra em diversas manifestações artísticas, analisando-a à luz de sólidos aportes teóricos que orientam e embasam as reflexões.
Elza Miné: A edição crítica de textos literários
Authors: Fronteiraz Revista 
Published: August 2022

Entrevista com a professora Elza Assumpção Miné sobre sua paixão pela palavra, sua formação híbrida e seu trânsito pela filologia, literatura e ensino. Graduada em Letras Neolatinas pela Pontifícia Universidade Católica de São Paulo (1957), com Doutorado em Letras (Literatura Portuguesa) pela Universidade de São Paulo (1970), Pós Doutorado no Kings College da Universidade de Londres (1973) e Livre Docência pela Universidade de São Paulo (1991), foi professora visitante do Programa de Pós Graduação em Estudos Literários na Universidade de Mato Grosso (2013-2017), e é professora colaboradora (aposentada) da Área de Pós Graduação em Estudos Comparados de Literaturas de Língua Portuguesa na Universidade de São Paulo (desde 1975 até o presente). Nessa entrevista, a professora relembra sua atuação na PUC-SP e seu trabalho no campo da edição crítica de textos literários, com ênfase nas obras de Eça de Queirós e Jaime Batalha Reis.
Edição: Ana Paula Rodrigues da Silva, Thiago Fonseca (TV-PUC)Música: PIPA estúdioRevista FronteiraZ 28 - Julho/2022