bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of deformation with damage progression behavior around a notch tip under creep and fatigue conditions for W-added 9Cr steel including weld joint
Authors: Yokobori A. Toshimitsu , Ishikawa Haruki , Sugiura Ryuji , Ohmi Toshihito , Tabuchi Masaaki 
Published: May 2022

Research concerning heat-resistant steels for the application in fossil-fired power plants has progressed remarkably during the past 60 years. This has resulted in improvements in the electrical efficiency of fossil-fired power plants. Currently, there are plans and programs to develop ultra-supercritical plants designed to operate at steam temperature and pressure conditions of 600/650 °C and 32 MPa. The W-added 9%Cr ferritic heat-resistant steel, that is, ASME grade P92, has been developed as a boiler material for this ultra-supercritical plant. Boiler materials, whose performance is critical for ultra-supercritical plant, are required to possess high creep resistant properties. In addition, these materials are exposed to fatigue induced by thermal stresses, that is, they are operated under creep-fatigue interacting conditions. In this study, mechanical tests under the condition of high temperature creep-fatigue interaction were conducted for P92 steel under stress-controlled and various load frequency conditions using the in-situ observational creep-fatigue testing machine to observe the damage formation behavior around a notch tip composed of voids in mesoscale. On the basis of these results, the effects of damage formation behavior on crack growth life were clarified. Furthermore, for the case of creep deformation, the numerical analyses of vacancy diffusion and concentration around a notch tip were conducted using our proposed numerical method of local stress-induced vacancy diffusion behavior, which is a nanoscale phenomenon to relate these behaviors to the damage formation behavior in mesoscale (μm scale).
Molar heat capacity of liquid Ti, Al20Ti80 and Al50Ti50 measured in electromagnetic levitation
Authors: Brillo Juergen , Wessing Johanna J. , Kobatake Hidekazu , Fukuyama Hiroyuki 
Published: May 2022

Temperature dependent isobaric molar heat capacity cP was measured in a containerless way for liquid Ti and two AlTi binary liquid alloys. The technique of electromagnetic levitation was used in combination with laser modulation calorimetry.
In all cases, linear temperature dependencies were found: At the corresponding liquidus temperatures, cP equals 49.75(±2.0) J∙K-1mol-1, 57.43(±2.9) J∙K-1mol-1, and 42.60(±2.2) J∙K-1mol-1, for Ti, Al20Ti80 and Al50Ti50, respectively. The respective temperature coefficients amount to -1.67∙10-2J∙K-2mol-1, -2.73∙10-2J∙K-2mol-1, and +7.83∙10-2J∙K-2mol-1. For liquid Ti, there is a good agreement with existing literature data. The results are discussed in relation to the Neumann-Kopp rule.
Implementación de un sistema de adquisición de datos, Convertidor Análogo Digital (CAD) de 16 Bits a bajo ruido
Authors: Moreno Rocha Christian Manuel , Medina Guzmán Andrés Alfredo 
Published: May 2022

En la actualidad existe un presuroso desarrollo de la electrónica y la microelectrónica, esto ha motivado que todas las esferas de la vida humana se estén automatizando, por ejemplo: la industria, el hogar, los comercios, la agricultura, la ganadería, el transporte, las comunicaciones, etc. En todo ese proceso de automatización el microprocesador y el microcontrolador toman un papel de suma importancia. Estos han permitido el desarrollo de sistemas inteligentes que son capaz de resolver los más diversos problemas, y son los llamados Sistemas de Adquisición de Datos.
El objetivo básico de los Sistemas de Adquisición de Datos es la unificación de los diferentes recursos que lo integran tales como: Transductores, multiplexores, amplificadores, conversores A/D y D/A, de memorias y puertos externos y creando con todo ello un sistema que se encargue de una aplicación específica como por ejemplo, es chequear unas variables (PH, humedad relativa, temperatura, iluminación, tensión eléctricas, concentración, etc ) para una posterior utilización de la misma ya sea con resultados para docentes, científicos, de almacenamiento o control y utilización de la misma.
Es por esto por lo que el objetivo principal de este proyecto fue el diseño y la elaboración de un dispositivo de adquisición de datos basado en conversor analógico digital de 16 bits y una etapa de acondicionamiento de bajo ruido, este dispositivo permite obtener, registrar y visualizar la información en un computador para su posterior estudio. La aplicación de este dispositivo puede estar proyectada para realizarse en el campo de la sismología, la medicina, la ingeniería civil, eléctrica o electrónica, etc., por ejemplo, si se deseara utilizar en la sismología, el equipo diseñado cuenta con un sensor magnético el cual podrá registrar y medir las variaciones en los movimientos terrestres ya provengan estos de terremotos o vibraciones provocadas para la exploración sísmica etc, sean de alta o baja magnitud.
Otro campo de aplicación del equipo diseñado puede ser en el registro de actividad electrodérmica, el cual es una técnica no invasiva que se utiliza para estudiar las reacciones corporales a diversos estímulos y tiene múltiples aplicaciones en el campo biomédico (dermatología, endocrinología, psicopatología, neurología, etc.).
Este artículo presenta la implementación de un sistema de adquisición de datos a 16 bits, donde se realizan mediciones de diferentes magnitudes de tensión y en presencia de muy bajo ruido gracias a la electrónica implementada, lo cual hace al dispositivo muy confiable y eficiente. El diseño se ha procurado poder brindar las siguientes características claves: tamaño reducido, conectividad con un ordenador personal, seguridad eléctrica, muy bajo ruido, posibilidad de incorporar nuevas funcionalidades y que sea de bajo costo y fácil adquisición y manipulación.
Identification of Angiogenesis-Related Prognostic Biomarkers Associated With Immune Cell Infiltration in Breast Cancer
Authors: Tao Dan , Wang Ying , Zhang Xin , Wang Can , Yang Dingyi , Chen Jing , Long Yanyan , Jiang Yong , Zhou Xian , Zhang Ningning 
Published: May 2022

Background: This study aimed to explore the prognostic value of angiogenesis-related genes (ARGs) and their association with immune cell infiltration (ICI) in breast cancer (BC).Methods: Transcriptome data of BC were obtained from the TCGA and GEO databases. Differentially expressed ARGs were identified by the limma package. The identification of key genes and construction of the risk score model were performed by univariate and multivariate Cox regression algorithms. The prognostic value of the risk score was assessed by ROC curves and nomogram. GO, KEGG pathway, and GSEA were used to investigate the biological functions of differentially expressed genes (DEGs), and CIBERSORT, ssGSEA, and xCell algorithms were performed to estimate the ICI in high-risk and low-risk groups. The correlations between prognostic biomarkers and differentially distributed immune cells were assessed. Moreover, a ceRNA regulatory network based on prognostic biomarkers was constructed and visualized by Cytoscape software.Results: A total of 18 differentially expressed ARGs were identified between tumor and adjacent normal tissue samples. TNFSF12, SCG2, COL4A3, and TNNI3 were identified as key prognostic genes by univariate and multivariate Cox regression analyses. The risk score model was further constructed based on the four-gene signature and validated in GSE7390 and GSE88770 datasets. ROC curves and nomogram indicated that the risk score had good accuracy for determining BC patient survival. Biological function analysis showed that DEGs in high- and low-risk groups had a high enrichment in immune-related biological processes and signaling pathways. Moreover, significantly different ICIs were found between high- and low-risk groups, such as memory B cells, CD8+ T cells, resting memory CD4+ T cells, follicular helper T cells, regulatory T cells, monocytes, M2 macrophages, and neutrophils, and each prognostic biomarker was significantly correlated with one or more immune cell types.Conclusion: The current study identified novel prognostic ARGs and developed a prognostic model for predicting survival in patients with BC. Furthermore, this study indicated that ICI may act as a bond between angiogenesis and BC. These findings enhance our understanding of angiogenesis in BC and provide novel guidance on developing therapeutic targets for BC patients.
Investigating the Impact of the TUITEK® Patient Support Programme, Designed to Support Caregivers of Children Prescribed Recombinant Human Growth Hormone Treatment in Taiwan
Authors: Su Pen-Hua , Malik Sumaira , Jheeta Amrit , Lin Yen-Fan , Su Su-Huei , Koledova Ekaterina , Graham Selina 
Published: May 2022

PurposePoor adherence to recombinant human growth hormone (r-hGH) treatment presents a significant barrier to achieving optimal growth outcomes. It is important to identify and address the treatment adherence-related needs of children prescribed r-hGH treatment, and develop new approaches to improve adherence. We aimed to measure the impact of the TUITEK® patient support programme, a multi-component personalized service intervention, on caregivers’ knowledge, beliefs, and perceptions of short stature and adherence to its treatment.Patients and MethodsThe evaluation of the TUITEK® patient support programme was conducted among 31 caregivers of children with short stature and receiving r-hGH treatment via the easypod™ auto-injector device in Taiwan. Caregivers within the ‘high risk’ category for knowledge, beliefs and perception factors influencing adherence to r-hGH treatment (disease and treatment coherence, emotional burden, self-administration, and treatment-related anxiety) were identified via the TUITEK® personalization questionnaire and followed up with bi-weekly telephone calls by a nurse practitioner over a 3-month period. A Wilcoxon signed-rank test was used to compare changes in questionnaire-based scoring patterns between baseline and follow-up.ResultsBetween baseline and follow-up, the percentage of caregivers scoring as ‘high risk’ for emotional burden reduced by 37%; there was an improvement in confidence of self-administration by 57% and the percentage of caregivers scoring as ‘high risk’ for treatment-related anxiety reduced by 52%. At follow-up, all caregivers classified as ‘high risk’ within the disease and treatment coherence item at baseline moved into the ‘low risk’ category. Statistically significant changes in questionnaire scores between baseline and follow-up for disease and treatment understanding, emotional burden, self-administration, and treatment-related anxiety were also observed.ConclusionThese findings indicate that the TUITEK® patient support programme can positively address disease and treatment-related barriers amongst caregivers regarding optimal adherence of their children to r-hGH treatment, which has the potential to positively impact on adherence levels and patient clinical health outcomes.
Worldwide Research Trends on Artemisinin: A Bibliometric Analysis From 2000 to 2021
Authors: Dong Yankai , Liu Lina , Han Jie , Zhang Lianqing , Wang Yi , Li Juan , Li Yuexiang , Liu He , Zhou Kun , Li Luyao , Wang Xin , Shen Xue , Zhang Meiling , Zhang Bo , Hu Xiaofei 
Published: May 2022

ObjectiveArtemisinin is an organic compound that comes from Artemisia annua. Artemisinin treatment is the most important and effective method for treating malaria. Bibliometric analysis was carried out to identify the global research trends, hot spots, scientific frontiers, and output characteristics of artemisinin from 2000 to 2021.MethodsPublications and their recorded information from 2000 to 2021 were retrieved through the Web of Science Core Collection (WoSCC). Using VOSviewer and Citespace, the hotspots and trends of studies on artemisinin were visualized.ResultsA total of 8,466 publications were retrieved, and for the past 22 years, the annual number of publications associated with artemisinin kept increasing. The United States published most papers. The H-index and number of citations of the United States ranked first. The University of Oxford and MALARIA JOURNAL were the most productive affiliation and journal, respectively. A paper written by E.A. Ashley in 2011 achieved the highest global citation score. Keywords, such as “malaria,” “artesunate,” “plasmodium-falciparum,” “in-vitro,” “artemisinin resistance,” “plasmodium falciparum,” “resistance,” and “artemether-lumefantrine,” appeared most frequently. The research on artemisinin includes clinical research and animal and cell experiments.ConclusionThe biosynthesis, drug resistance mechanism, and combination of artemisinin have become more popular than before. Studies on artemisinin treating coronavirus disease 2019 (COVID-19) have been carried out, and good research results have been obtained.
Clinical Effects of Rehabilitation on Balance in People With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Authors: Canales-Díaz María Belén , Olivares-Valenzuela Carolina , Ramírez-Arriagada Amanda , Cruz-Montecinos Carlos , Vilaró Jordi , Torres-Castro Rodrigo , Núñez-Cortés Rodrigo 
Published: May 2022

BackgroundPatients with chronic obstructive pulmonary disease (COPD) have systemic damage secondary to the primary pulmonary impairment, expressed in impaired peripheral musculature and a deficit in postural control compared to healthy subjects. This study aimed to determine the effects of rehabilitation on balance in patients with COPD.MethodsAn exhaustive search was conducted in four databases (Pubmed, Cochrane Library, EMBASE, Web of Science). Articles with a population of COPD receiving rehabilitation (therapeutic exercise, pulmonary rehabilitation, or physical therapy modalities) in an outpatient setting were included. Two independent reviewers selected and assessed the study quality. The risk of bias was assessed with the Cochrane Risk of Bias Tool for Randomized Controlled Trials.ResultsA total of eight studies involving 284 patients were included in the qualitative synthesis. The meta-analysis showed an overall result in favor of balance training for the Berg Balance Scale (mean difference 3.91 points; 95% CI: 1.51 to 6.31; P = 0.001), Timed Up and Go test (mean difference −1.58 s; 95% CI: −2.63 to −0.53; P = 0.003) and Unipedal stance test (mean difference 3.56 s, 95% CI: 2.58 to 4.54; P).ConclusionThis meta-analysis revealed that rehabilitation improve static and dynamic balance in patients with COPD.Systematic Review RegistrationPROSPERO ID: CRD42020218367.
Attitudes of Primary School Teachers and Its Associated Factors Toward Students With Attention Deficit Hyperactivity Disorder in Debre Markos and Dejen Towns, Northwest Ethiopia
Authors: Amha Haile , Azale Telake 
Published: May 2022

BackgroundAlthough most instructors appear to understand visible disability, they appear to have a negative attitude toward children with attention deficit hyperactivity disorder (ADHD), considering them to be lazy or purposefully disruptive. In Ethiopia, there is a scarcity of data on teachers’ attitudes toward children with ADHD.MethodsAn institution-based cross-sectional study was conducted. A pre-tested questionnaire that contains a case vignette was administered through face-to-face interview with 417 teachers. The data was entered into Epi-data version 4.2 and exported into SPSS version 25.0 for analysis. Multiple linear regression analyses were used to assess the correlates of attitude in the participants and a B coefficient with 95% confidence interval (CI) were used. The statistical significance was accepted at p-value &lt; 0.05.ResultsThe mean score of the teachers’ attitude toward ADHD was 41.6 ± 5.4 (95% CI; 41.12, 42.16) and 46% of the participants had unfavorable attitudes. Low level of educational status, knowledge, teaching experience, familiarity in teaching students with ADHD, and having training were significantly associated with attitude of the teachers.ConclusionThe study revealed that nearly half of the participants had an unfavorable attitude toward students with ADHD. Based on the findings, it was recommended that it is better to strengthen training of teachers to recognize students with ADHD.
Case Report: Role of Ketone Monitoring in Diabetic Ketoacidosis With Acute Kidney Injury: Better Safe Than Sorry
Authors: Tinti Davide , Savastio Silvia , Peruzzi Licia , De Sanctis Luisa , Rabbone Ivana 
Published: May 2022

BackgroundType 1 Diabetes (T1D) is a well-known endocrinological disease in children and adolescents that is characterized by immune-mediated destruction of pancreatic β-cells, leading to partial or total insulin deficiency, with an onset that can be subtle (polydipsia, polyuria, weight loss) or abrupt (Diabetic Keto-Acidosis, hereafter DKA, or, although rarely, Hyperosmolar Hyperglycemic State, hereafter HHS). Severe DKA risk at the onset of T1D has recently significantly increased during the SARS-CoV-2 pandemic with life-threatening complications often due to its management. DKA is marked by low pH (&lt;7.3) and bicarbonates (&lt;15 mmol/L) in the presence of ketone bodies in plasma or urine, while HHS has normal pH (&gt;7.3) and bicarbonates (&gt;15 mmol/L) with no or very low ketone bodies. Despite this, ketone monitoring is not universally available, and DKA diagnosis is mainly based on pH and bicarbonates. A proper diagnosis of the right form with main elements (pH, bicarbonates, ketones) is essential to begin the right treatment and to identify organ damage (such as acute kidney injury).Case PresentationsIn this series, we describe 3 case reports in which the onset of T1D was abrupt with severe acidosis (pH &lt; 7.1) in the absence of both DKA and HHS. In a further evaluation, all 3 patients showed acute kidney injury, which caused low bicarbonates and severe acidosis without increasing ketone bodies.ConclusionEven if it is not routinely recommended, a proper treatment that included bicarbonates was then started, with a good response in terms of clinical and laboratory values. With this case series, we would like to encourage emergency physicians to monitor ketones, which are diriment for a proper diagnosis and treatment of DKA.
Are We Ready for Newborn Genetic Screening? A Cross-Sectional Survey of Healthcare Professionals in Southeast China
Authors: Wu Xian , Yang Yuqi , Zhou Lingna , Long Wei , Yu Bin 
Published: May 2022

ObjectivesTo understand the knowledge, attitude, willingness, and ability of healthcare professionals working in newborn screening (NBS) centers regarding newborn genetic screening (nGS).MethodsThe questionnaire consisted of four sections with 27 questions and the data were collected by the WJX platform. All participants accessed the questionnaire by scanning a specific QR code with their mobile phones. Two researchers independently completed the summary and analysis.ResultsA total of 258 valid questionnaires were collected from 43 NBS centers in six provinces of southeast China. In total, 209 (81.01%) participants were interested in nGS, and almost all participants (97.67%) thought that nGS was necessary in China. About 89.53% of participants thought that it could be used to effectively expand the diseases that could be screened, but 72.87% also worried about the inability to provide genetic counseling. About 55.34% suggested that nGS and tandem mass spectrometry (TMS) screening could be applied in a unite screening mode. The higher the institution and personal education levels, the higher the interest healthcare professionals displayed toward nGS. However, they also showed greater concern about the inability to provide genetic counseling and ethical issues. If a center had engaged in TMS screening, its staff would have been more likely to believe that nGS had great advantages. In addition, most participants had ethical concerns, such as “the psychological burden caused by carrying information regarding adult morbidity risk.”ConclusionMost participants were interested and considered nGS necessary. The inability to provide genetic counseling may be the primary impediment to clinical practice. Three important influencing factors were level of education, institution level, and engagement in TMS screening.
Screening for Distress in Oncological Patients: The Revised Version of the Psychological Distress Inventory (PDI-R)
Authors: Rossi Alessandro Alberto , Marconi Maria , Taccini Federica , Verusio Claudio , Mannarini Stefania 
Published: May 2022

BackgroundPsychological research in oncological settings is steadily increasing and the construct of psychological distress has rapidly gained popularity—leading to the development of questionnaires aimed at its measurement. The Psychological Distress Inventory (PDI) is one of the most used instruments, but its psychometric properties were not yet deeply evaluated. The present studies aimed at investigating the psychometric properties of the PDI (Study 1) and providing a revised version of the tool (Study 2).MethodsOncological outpatients were enrolled at the Department of Medical Oncology of the Presidio Ospedaliero of Saronno, ASST Valle Olona, Italy. For the first study (N= 251), an Exploratory Graph Analysis was used to explore the item structure of the PDI. In the second study (N= 902), the psychometric properties of the revised PDI (PDI-R) were deeply assessed.ResultsStudy 1 showed that the PDI has a not clear structure and it should be reconsidered. On the opposite, Study 2 showed that the revised version (PDI-R) has a solid factorial structure, it is invariant across gender and age, and it has good psychometric properties.ConclusionResults suggest that the PDI-R is a reliable measure of psychological distress in different samples of oncological patients, with stronger psychometric properties than the original version. Its use in the clinical and research field is therefore recommended to improve the quality of both assessment and treatment of psychological distress in patients with oncological problems.
Attitudes of Primary School Teachers Toward Inclusive Education
Authors: Radojlovic Jasmina , Kilibarda Tatjana , Radevic Svetlana , Maricic Milena , Parezanovic Ilic Katarina , Djordjic Milan , Colovic Sofija , Radmanovic Branimir , Sekulic Marija , Djordjevic Ognjen , Niciforovic Jovan , Simic Vukomanovic Ivana , Janicijevic Katarina , Radovanovic Snezana 
Published: May 2022

BackgroundThe aims of our study are related to examining the relevance of teachers' attitudes toward the implementation of inclusive education. In addition, its subject is related to the implications on inclusive education policies, limitations of the existing study along with the recommendations for our future research endeavors.MethodsThe research is a cross-sectional study type. The sample included 64 primary school teachers in the lower grades of primary school (grades 1–4), selected by using simple random sampling, in three primary schools on the territory of Belgrade, Serbia in 2021 (26, 17, and 21 primary school teachers). The Questionnaire for Teachers, which was used as a research instrument, was taken from the Master's Thesis Studen Rajke, which was part of the project “Education for the Knowledge Society” at the Institute for Educational Research in Belgrade. Dependent variables measured in the study referred to the attitudes of primary school teachers toward inclusive education. Categorical variables are represented as frequencies and the Chi-square test was used to determine if a distribution of observed frequencies differed from the expected frequencies.ResultsOne in three teachers (32.8%) thought that inclusion was useful for children with disabilities (29.7%), of them thought that schools did not have the conditions for inclusive education, whereas one in four teachers (25.0%) believed that inclusion was not good. No statistically significant differences were found in the attitudes of professors, when observed in terms of their gender, age and length of service.ConclusionInvesting more resources and time in developing and implementing special education policies can promote successful inclusive education.