bluuebunny/crossref_metadata_2025_split huggingface dataset:
An attempt to valorize the only black meat chicken breed of India by delineating superior functional attributes of its meat
Authors: Sharma Rekha , Sehrawat Renuka , Ahlawat Sonika , Sharma Vivek , Parmar Alka , Thakur M. S. , Mishra A. K. , Tantia M. S. 
Published: March 2022

AbstractKadaknath, the only black chicken indigenous to India, faces the threat of extinction due to declining numbers. Its meat is used in tribal medicine for invigorating and health-promoting properties. Expectations of immune-boosting and therapeutic properties in its meat are creating a buzz these days. Thus, Kadaknath meat was explored and further compared with the commercial Cobb 400 broiler (Cobb) for the functional traits that might be contributing towards proclaimed pharmacological benefits. Birds (n = 20/ group) were raised under similar management conditions and the two primal chicken meat cuts (breast and thigh) were collected at the marketing age. Kadaknath meat was found to be an enriched source of functional biomolecules (carnosine, anserine, creatine). Its breast meat carnosine content was more than double of the Cobb broiler, 6.10 ± 0.13 and 2.73 ± 0.1 mg/ g of wet tissue, respectively. Similarly, the thigh meat of Kadaknath was a significantly (P < 0.05) richer source of carnosine. The genetic background was a key determinant for muscle carnosine content as a significant abundance of CARNS1 and SLC36A1 expression was identified in the Kadaknath breast. The superior functional property of Kadaknath meat was established by the antioxidant capacity established by the Oxygen radical absorbance capacity assay and a stronger ability to inhibit the formation of advanced glycation end products (AGEs). The identification of fairly unknown nutritional and functional advantages of Kadaknath meat could potentially change the paradigm with its meat consumption. It will help in developing a brand name for Kadaknath products that will propel an increase in its market share and ultimately conservation of this unique but endangered poultry germplasm.
On track to achieve no net loss of forest at Madagascar’s biggest mine
Authors: Devenish Katie , Desbureaux Sébastien , Willcock Simon , Jones Julia P. G. 
Published: March 2022

AbstractMeeting the UN Sustainable Development Goals requires reconciling development with biodiversity conservation. Governments and lenders increasingly call for major industrial developments to offset unavoidable biodiversity loss but there are few robust evaluations of whether offset interventions ensure no net loss of biodiversity. We focus on the biodiversity offsets associated with the high-profile Ambatovy mine in Madagascar and evaluate their effectiveness at delivering no net loss of forest. As part of their efforts to mitigate biodiversity loss, Ambatovy compensate for forest clearance at the mine site by slowing deforestation driven by small-scale agriculture elsewhere. Using a range of methods, including extensive robustness checks exploring 116 alternative model specifications, we show that the offsets are on track to avert as much deforestation as was caused by the mine. This encouraging result shows that biodiversity offsetting can contribute towards mitigating environmental damage from a major industrial development, even within a weak state, but there remain important caveats with broad application. Our approach could serve as a template to facilitate other evaluations and so build a stronger evidence-base of the effectiveness of no net loss interventions.
Quality of life and metabolic outcomes after total pancreatectomy and simultaneous islet autotransplantation
Authors: Ludwig Stefan , Distler Marius , Schubert Undine , Schmid Janine , Thies Henriette , Welsch Thilo , Hempel Sebastian , Tonn Torsten , Weitz Jürgen , Bornstein Stefan R. , Ludwig Barbara 
Published: March 2022

Abstract
Background
Pancreas surgery remains technically challenging and is associated with considerable morbidity and mortality. Identification of predictive risk factors for complications have led to a stratified surgical approach and postoperative management. The option of simultaneous islet autotransplantation (sIAT) allows for significant attenuation of long-term metabolic and overall complications and improvement of quality of life (QoL). The potential of sIAT to stratify a priori the indication for total pancreatectomy is yet not adequately evaluated.

Methods
The aim of this analysis was to evaluate the potential of sIAT in patients undergoing total pancreatectomy to improve QoL, functional and overall outcome and therefore modify the surgical strategy towards earlier and extended indications. A center cohort of 24 patients undergoing pancreatectomy were simultaneously treated with IAT. Patients were retrospectively analyzed regarding in-hospital and overall mortality, postoperative complications, ICU stay, hospital stay, metabolic outcome, and QoL.

Results
Here we present that all patients undergoing primary total pancreatectomy or surviving complicated two-stage pancreas resection and receiving sIAT show excellent metabolic outcome (33% insulin independence, 66% partial graft function; HbA1c 6,1 ± 1,0%) and significant benefit regarding QoL. Primary total pancreatectomy leads to significantly improved overall outcome and a significant reduction in ICU- and hospital stay compared to a two-stage completion pancreatectomy approach.

Conclusions
The findings emphasize the importance of risk-stratified pancreas surgery. Feasibility of sIAT should govern the indication for primary total pancreatectomy particularly in high-risk patients. In rescue completion pancreatectomy sIAT should be performed whenever possible due to tremendous metabolic benefit and associated QoL.
Case Study: Using H5P to design and deliver interactive laboratory practicals
Authors: Unsworth Amanda J. , Posner Mareike G. 
Published: March 2022

AbstractWe describe the use of HTML5P (H5P) content collaboration framework to deliver an interactive, online alternative to an assessed laboratory practical on the Biomedical Cell Biology unit at the Manchester Metropolitan University, U.K. H5P is free, open-source technology to deliver bespoke interactive, self-paced online sessions. To determine if the use of H5P affected learning and student attainment, we compared the student grades among three cohorts: the 18/19 cohort who had ‘wet’ laboratory classes, the 19/20 cohort who had ‘wet’ laboratory classes with additional video support and the 20/21 cohort who had the H5P alternative. Our analysis shows that students using the H5P were not at a disadvantage to students who had ‘wet’ laboratory classes with regard to assessment outcomes. Student feedback, mean grade attained and an upward trend in the number of students achieving first-class marks (≥70%), indicate H5P may enhance students’ learning experience and be a valuable learning source augmenting traditional practical classes in the future.
Test Your Health at Home: Comparing Online Screening Tests of Hearing, Cognition, and Cardiovascular Health
Authors: Goodwin Maria V. , Hogervorst Eef , Maidment David W. 
Published: March 2022

Purpose:
The purpose of this study was to investigate the extent to which validated online screening measures of cognitive impairment, psychosocial well-being, and cardiovascular health are associated with a validated hearing screener in a sample of adults based in the United Kingdom.

Method:

Sixty-one adults (43 female;
M
age
= 44.7 years) participated in a cross-sectional study delivered remotely. Participants completed the hearWHO smartphone application, a digits-in-noise hearing screener, and the Modified Telephone Interview for Cognitive Status (TICS-M), a screening tool for cognitive impairment. Psychosocial well-being (social isolation and loneliness) and cardiovascular health were assessed through self-report.

Results:
Separate independent analyses of variance, with age, gender, and education as covariates, demonstrated participants who failed the hearWHO screener had poorer scores on the TICS-M, engaged in less physical activity, and reported more sedentary behavior and greater social isolation. Multivariate regression analyses revealed that lower TICS-M scores, having obtained less education, identifying as female, and reporting greater sedentary behavior and social isolation were the strongest predictors of lower hearWHO scores.

Conclusions:
The results from this study suggest that poorer hearing, as measured by the hearWHO screener, is independently associated with having worse cognitive function, more time spent being sedentary, and greater social isolation. Thus, this study demonstrates the potential of online screening measures to identify additional health conditions that confer risk to chronic disease as hearing loss manifests. This could help to inform the development of tailored treatment and support to improve an individual's readiness to seek help for and manage both their general and hearing health.

Supplemental Material:

https://doi.org/10.23641/asha.19251956
Individual Differences in the Development of Gendered Speech in Preschool Children: Evidence From a Longitudinal Study
Authors: Munson Benjamin , Lackas Natasha , Koeppe Kiana 
Published: March 2022

Purpose:
We evaluated whether naive listeners' ratings of the gender typicality of the speech of children assigned male at birth (AMAB) and children assigned female at birth (AFAB) were different at two time points: one at which children were 2.5–3.5 years old and one when they were 4.5–5.5 years old. We also examined whether measures of speech, language, and inhibitory control predicted developmental changes in these ratings.

Method:

A group of adults (
N
= 80) rated single-word productions of 55 AMAB and 55 AFAB children on a continuous scale from “definitely a boy” to “definitely a girl.” Children's productions were taken from previous longitudinal study of phonological development and vocabulary growth. As part of that study, children completed a battery of standardized and nonstandardized tests at both time points.

Results:
Listener ratings for AMAB and AFAB children were significantly different at both time points. The difference was larger at the later time point, and this was due entirely to changes in the ratings of AMAB children's speech. A measure of language production and a measure of inhibitory control predicted developmental changes in these ratings, albeit only weakly, and not in a consistent direction.

Conclusions:
The gender typicality of AMAB and AFAB children's speech is perceptibly different for children as young as 2.5 years old. Developmental changes in perceived gender typicality are driven by changes in the speech of AMAB children. The learning of gendered speech is not constrained or facilitated by overall speech and language skill.
A Midsagittal-View Magnetic Resonance Imaging Study of the Growth and Involution of the Adenoid Mass and Related Changes in Selected Velopharyngeal Structures
Authors: Perry Jamie L. , Haenssler Abigail E. , Kotlarek Katelyn J. , Fang Xiangming , Middleton Shea , Mason Robert , Kuehn David P. 
Published: March 2022

Purpose:
The adenoids, or pharyngeal tonsils, consist of a pad of lymphoid tissue, located on the posterior pharyngeal wall of the nasopharynx. During childhood, the adenoid pad serves as a contact site for the soft palate to assist with velopharyngeal closure during oral speech. During adenoidal involution, most children are able to maintain appropriate velopharyngeal closure necessary for normal speech resonance. The purpose of this study is to determine age-related trends of normal adenoid growth and involution from infancy through adulthood.

Method/Description:
Lateral view magnetic resonance imaging was used to analyze velopharyngeal variables among 270 participants, between 3 months and 34 years of age. The velopharyngeal measures of interest included velar length, effective velar length, pharyngeal depth, adenoid height, adenoid thickness, adenoid depth, and adenoid area. Participants were divided into four age groups for statistical comparison.

Results:

There was a statistically significant difference (
p
< .05) in all linear and area measurements between the four age groups. Adenoid depth reached peak growth at age 4 years, whereas adenoid height and adenoid thickness peaked at 8 years of age. Qualitatively, adenoid growth progresses in an anterior and inferior direction whereas involution occurs in a posterior and superior direction.

Conclusions:
This study contributes to the knowledge of time specific changes across an age span for adenoid growth and involution and presents a visualization of the shape and growth trends of adenoids. A new sequence of involution is reported beginning first with adenoid depth, followed by adenoid height at a slightly faster rate than adenoid thickness.
A novel spoke‐type PM motor with asymmetric rotor for low torque pulsation under MTPA control condition
Authors: Liu Zeyu , Hu Yan , Zhang Bingyi , Feng Guihong , Wu Jiacheng 
Published: March 2022

AbstractThis article presents a novel asymmetric spoke‐type rotor structure. It is used to reduce rotor magnetic flux leakage, torque ripple and no‐load back‐EMF distortion rate while increasing the motor output torque. The traditional method of optimizing torque pulsation is the inverse cosine function, which gives a sinusoidal distribution of the air‐gap magnetic field under no‐load conditions of the motor. The fundamental wave magnetic field of the air‐gap synthetic magnetic field under the load is offset from the no‐load air‐gap magnetic field. This paper presents the design theory and method of the new type of the asymmetric rotor. Asymmetric spatial harmonics are introduced to the rotor so that the motor has a sinusoidal distribution of the rated load air‐gap field under MTPA control. In order to verify the superiority of the new rotor, the performance of four different spoke‐type rotor structure motors under the same pole‐slot combination was compared. Finally, an experimental prototype is built to verify the theoretical reliability against the design of this paper.
Ovalbumin loaded CuS nanoparticle for tumour modulation and enhanced immunotherapy of osteosarcoma
Authors: Cui Xintao , Rong Jiesheng , Cong Chunlei 
Published: March 2022

AbstractThe CuS nanoparticle was firstly synthesized and then loaded with ovalbumin (OVA) as a platform (CuS/OVA) for combination of photothermal and immunogenic therapy of osteosarcoma. The CuS with photothermal activity was able to generate heat under laser irradiation to kill cancer cells. Moreover, the enzymatic activity was shown to exert the potential to catalyse the degradation of H2O2 in the tumour microenvironment to alleviate the hypoxia condition. Due to this tumour modulation effect, the delivered antigen OVA can be effectively presented to the dendritic cell (DC) for enhanced immunotherapy of osteosarcoma.
Robust control strategies for a two‐stage soft‐switching heating power supply of silicon growth furnace
Authors: Guo Xin 
Published: March 2022

AbstractAs a key element of the silicon growth furnace, the heating power supply plays an important role to form the required thermal field for mono‐silicon growth. The performance of the heating power supply system is critical to implement the function, which is determined by both hardware topology and control strategies. In this paper, a novel two‐stages soft‐switching power supply topology is employed to improve the efficiency of the power supply system. Meanwhile, the robust control methods are proposed for both stages converter to achieve high power factor (PF), low total harmonic distortion (THD) and stable output DC voltage under parameters uncertainty or load perturbation. The simulation and experiment results show the correctness of analysis and the effectiveness of the proposed methods. The robust control strategies combined with the advanced soft switching topology improve the system performance for the practical applications.
Performance of coherent‐state quantum target detection in the context of asymmetric hypothesis testing
Authors: Spedalieri Gaetana , Pirandola Stefano 
Published: March 2022

AbstractDue to the difficulties of implementing joint measurements, quantum illumination schemes that are based on signal‐idler entanglement are difficult to implement in practice. For this reason, one may consider quantum‐inspired designs of quantum lidar/radar where the input sources are semi‐classical (coherent states) while retaining the quantum aspects of the detection. The performance of these designs could be studied in the context of asymmetric hypothesis testing by resorting to the quantum Stein’s lemma. However, here the authors discuss that, for typical finite‐size regimes, the second‐ and third‐order expansions associated with this approach are not sufficient to prove quantum advantage.
Interferometric ISAR imaging under squint model using phase cancellation compensation method of combined processing data
Authors: Tian Biao , Chen Chengzeng , Liu Yang , Guo Rui 
Published: March 2022

AbstractThis paper proposes a new interferometric inverse synthetic aperture radar (InISAR) image registration method under squint model based on phase cancellation compensation of combined processing data. Firstly, the residue translational motion component (RTMC) in range profile and the mismatching in the ISAR images induced by joint motion compensation with the same parameters to each antenna are analysed. Then, the RTMC compensation is applied to re‐align the range profile sequences of the received antenna. The phase cancellation compensation is carried out to eliminate the mismatching in the range and azimuth direction, respectively. Simulation results demonstrate that the mismatching between the ISAR images can be compensated effectively, achieving high quality InISAR 3D images consequently.
Funktionelle Neuroanatomie der Depression
Authors: Kammer Thomas 
Published: March 2022

ZUSAMMENFASSUNGZur funktionellen Neuroanatomie der Depression gehört schon lange die Einsicht, dass es kein „Depressionszentrum“ gibt, sondern vielmehr Bereiche von grauer Substanz (kortikale Areale und subkortikale Kerne), die durch Nervenfaserbündel verbunden sind und daher oft als „Netzwerke“ oder „Schaltkreise“ bezeichnet werden. In den letzten Jahrzehnten ist es besonders durch die funktionelle Bildgebung möglich geworden, diese Netzwerke sowohl bei gesunden Probanden als auch bei Patienten mit Depression darzustellen, und Änderungen in der funktionellen Verknüpfung der Netzwerke zu identifizieren, die im Zusammenhang mit der Psychopathologie stehen. Vor diesem Hintergrund ist auch das Verständnis gewachsen, wie Hirnstimulationsverfahren wie die tiefe Hirnstimulation (THS) oder die repetitive transkranielle Magnetstimulation (rTMS) durch Modulation der Netzwerkfunktion ihre therapeutische Wirkung entfalten. In einem Rückblick wird die Entwicklung der funktionellen Bildgebung sowie der Hirnstimulationsverfahren nachgezeichnet und es werden aktuelle Entwicklungen des Einsatzes dieser Verfahren erörtert. Neuere Studien zur rTMS-Behandlung postulieren, dass der optimale Stimulationsort in Abhängigkeit von der psychopathologischen Ausprägung der Depression ausgewählt werden kann, unter Berücksichtigung der veränderten Konnektivität. Im Bereich der THS ist ein Fallbericht erschienen, in dem zunächst ein Mapping mit 10 implantierten Elektroden durchgeführt wurde. Verschiedene Stimulationsorte haben zu reproduzierbaren instantanen Veränderungen der Psychopathologie geführt. Die Patientin ist nun mit einer Closed-loop-Stimulation chronisch versorgt, die über Aktivität der rechten Amygdala geregelt wird.
Leveraging Potential of Nanotherapeutics in Management of Diabetic
Foot Ulcer
Authors: Pandey Supriya , Shaif Mohammad , Ansari Tarique M , Shamim Arshiya , Kushwaha Poonam 
Published: March 2022

AbstractDiabetic foot ulcers (DFUs) are the most common complications associated with
diabetes mellitus. DFUs are displayed as open sores or wounds located on the
bottom of the foot as a secondary complication of diabetes mellitus (DM). DFUs
are associated with significant morbidity and mortality and can subsequently
lead to hospitalization and lower limb amputation if not recognized and treated
on time. An immense challenge to conventional treatments is caused by the
chronic nature of diabetic foot syndrome and it has led to the emergence of
nanotechnology-based therapeutics. The greatest advantages of these
nanotherapeutics are their unique biological, chemical, and physical properties.
The present review highlights the augmentation of bacterial infections relating
to delayed healing of DFUs and the potential of nanotherapeutics such as
polymeric nanoparticles, metallic nanoparticles, siRNA-based nanoparticles,
lipid nanoparticles, and nanofibers in accelerating wound healing in diabetic
foot ulcers.
Using Restricted Bond Rotations to Enforce Excited-State Behavior of Organic Molecules
Authors: Sivaguru Jayaraman , Kandappa Sunil Kumar , Ahuja Sapna , Singathi Ravichandranath , Valloli Lakshmy Kannadi , Baburaj Sruthy , Parthiban Jayachandran 
Published: March 2022

This account highlights the role of restricted bond rotations in influencing the excited-state reactivity of organic molecules. It highlights the photochemical reactivity of various organic molecules and the design strategies that could be exploited by chemists to utilize restricted bond rotations to uncover new excited-state reactivity and to achieve selectivity.1	Introduction.2	NEER-Principle and Restricted Bond Rotations in the Excited State3	[2+2]-Photocycloaddition of Enamides4	[3+2]-Photocycloaddition vs. Paternò–Büchi Reaction of Enamides5	Divergent Photoreactivity of Enones Dictated by Restricted Bond Rotations: Norrish–Yang reactions vs. 6π-Photocyclization6	Divergent Photoreactivity of Imides with Alkenes: [2+2]-Photocycloaddition vs. Photoene Reaction7	Summary and Outlook