bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic-assisted versus laparoscopic rectal surgery in obese and morbidly obese patients: ACS-NSQIP analysis
Authors: Albayati Sinan , Hitos Kerry , Berney Christophe R. , Morgan Matthew J. , Pathma-Nathan Nimalan , El-Khoury Toufic , Richardson Arthur , Chu Daniel I. , Cannon Jamie , Kennedy Greg , Toh James Wei Tatt 
Published: October 2022

AbstractLaparoscopic rectal surgery within the confines of a narrow pelvis may be associated with a high rate of open conversion. In the obese and morbidly obese patient, the complexity of laparoscopic surgery increases substantially. Robotic technology is known to reduce the risk of conversion, but it is unclear if it can overcome the technical challenges associated with obesity. The ACS NSQIP database was used to identify obese patients who underwent elective laparoscopic or robotic-assisted rectal resection from 2015 to 2016. Obesity was defined as a body mass index (BMI) greater than or equal to 30 kg/m2. Morbid obesity was defined as a BMI greater than or equal to 35 kg/m2. The primary outcome was unplanned conversions to open. Other outcomes measures assessed included anastomotic leak, operative time, surgical site infections, length of hospital stay, readmissions and mortality. Statistical analyses were performed using SPSS 22.0 (IBM SPSS, USA). 1490 patients had robotic-assisted and 4967 patients had laparoscopic rectal resections between 2015 and 2016. Of those patients, 561 obese patients had robotic-assisted rectal resections and 1824 patients underwent laparoscopic rectal surgery. In the obese cohort, the rate of unplanned conversion to open in the robotic group was 14% compared to 24% in the laparoscopic group (P < 0.0001). Median operative time was significantly longer in the robotic group (248 min vs. 215 min, P < 0.0001). There was no difference in anastomotic leak or systemic sepsis between the laparoscopic and robotic rectal surgery groups. In morbidly obese patients (BMI ≥ 35 kg/m2), the rate of unplanned conversion to open in the robotic group was 19% compared to 26% in the laparoscopic group (P < 0.027). There was no difference in anastomotic leak, systemic sepsis or surgical site infection rates between robotic and laparoscopic rectal resection. Multivariate analysis showed that robotic-assisted surgery was associated with fewer unplanned conversions to open (OR 0.28, P < 0.0001). Robotic-assisted surgery is associated with a decreased risk of conversion to open in obese and morbidly obese patients when compared to conventional laparoscopic surgery. However, robotic surgery was associated with longer operative time and despite improvement in the rate of conversion to open, there was no difference in complications or length of stay. Our findings are limited by the retrospective non-randomised nature of the study, demographic differences between the two groups, and the likely difference in surgeon experience between the two groups. Large randomised controlled studies are needed to further explore the role of robotic rectal surgery in obese and morbidly obese patients.
Alterations in Stem Cell Populations in IGF-1 Deficient Pediatric Patients Subjected to Mecasermin (Increlex) Treatment
Authors: Kamil Grubczak , Karolina Stożek , Aleksandra Starosz , Filip Bossowski , Marta Pasławska , Artur Bossowski , Marcin Moniuszko 
Published: October 2022

AbstractPathway involving insulin-like growth factor 1 (IGF-1) plays significant role in growth and development. Crucial role of IGF-1 was discovered inter alia through studies involving deficient patients with short stature, including Laron syndrome individuals. Noteworthy, despite disturbances in proper growth, elevated values for selected stem cell populations were found in IGF-1 deficient patients. Therefore, here we focused on investigating role of these cells—very small embryonic-like (VSEL) and hematopoietic stem cells (HSC), in the pathology. For the first time we performed long-term observation of these populations in response to rhIGF-1 (mecasermin) therapy. Enrolled pediatric subjects with IGF-1 deficiency syndrome were monitored for 4–5 years of rhIGF-1 treatment. Selected stem cells were analyzed in peripheral blood flow cytometrically, together with chemoattractant SDF-1 using immunoenzymatic method. Patients’ data were collected for correlation of experimental results with clinical outcome. IGF-1 deficient patients were found to demonstrate initially higher levels of VSEL and HSC compared to healthy controls, with their gradual decrease in response to therapy. These changes were significantly associated with SDF-1 plasma levels. Correlations of VSEL and HSC were also reported in reference to growth-related parameters, and IGF-1 and IGFBP3 values. Noteworthy, rhIGF-1 was shown to efficiently induce development of Laron patients achieving at least proper rate of growth (compared to healthy group) in 80% of subjects. In conclusion, here we provided novel insight into stem cells participation in IGF-1 deficiency in patients. Thus, we demonstrated basis for future studies in context of stem cells and IGF-1 role in growth disturbances.
Graphical abstract
Timing of additional neoadjuvant chemotherapy in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy and total mesorectal excision
Authors: He Fang , Chen Mo , Liu Yan-ping , Sun Jiachun , Zheng Jian 
Published: October 2022

Abstract
Background
In locally advanced rectal cancer (LARC), the optimal sequence of neoadjuvant chemotherapy in relation to neoadjuvant chemoradiotherapy and before total mesorectal excision is unknown.

Methods
A total of 426 LARC patients, treated with neoadjuvant chemoradiotherapy followed by total mesorectal excision, between January 2010 and December 2018, were studied retrospectively. Patients were divided into induction and consolidation chemotherapy groups. Overall, disease-free, locoregional relapse-free, and distant metastasis-free survival rates for the 2 groups were compared. Multivariate analysis hazard ratios (HR) with 95% confidence intervals (CI) to identify survival predictors.

Results
Median follow-up was 37 (range, 7–162) months. The 3-year overall, disease-free, locoregional relapse-free, and distant metastasis-free survival rates were 93.8%, 71.6%, 93.5%, and 74.4%, respectively. For those receiving either induction or consolidation chemotherapy, 3-year disease-free survival rates were 82.5% and 67.7%, respectively (P = 0.021), distant metastasis-free rates were 85.4% and 70.8%, respectively (P = 0.024), and both overall and locoregional relapse-free survival rates did not differ significantly. Absence of neural invasion was an independent predictor of disease-free (HR = 0.49, 95% CI 0.25–0.97, P = 0.04) and distant metastasis-free (HR = 0.49, 95% CI 0.25–0.98, P = 0.04) survival. Both ypTN stage III (vs.0-II) and consolidation (vs. induction) chemotherapy were independent predictors of disease relapse (HR = 1.95, 95% CI 1.47–2.58, P < 0.001; HR = 1.68, 95% CI 1.01–2.79, P = 0.046; respectively) and distant metastasis (HR = 2.04, 95% CI 1.51–2.76, P < 0.001; HR = 1.75, 95% CI 1.03–2.99, P = 0.04; respectively).

Conclusions
LARC patients receiving neoadjuvant chemoradiotherapy and total mesorectal excision had better disease-free and distant metastasis-free survival, with induction rather than consolidation neoadjuvant chemotherapy.
Social network interventions in the space of topological relationships between communities
Authors: Corcoran Padraig , Reinecke Philipp , Innes Martin 
Published: October 2022

AbstractA social network intervention is a process of intentionally altering a social network to achieve an objective. The objective in question may concern accelerating behaviour change or improving organisational performance. In this work we propose a novel model of social network interventions which considers topological properties of relationships existing between communities. Broadly speaking, topological properties of such relationships include properties described by natural language descriptions such as contains, partial overlap and disjoint. The proposed model provides an abstraction which in many cases is useful for solving problems involving social network interventions. We demonstrate this by simulating interventions on a number of hypothetical and real social networks in the domains of health and security.
Gender differences in reading and numeracy achievement across the school years
Authors: Thomas Damon P. , Hopwood Belinda , Hatisaru Vesife , Hicks David 
Published: October 2022

AbstractDeveloping students’ reading and numeracy skills remain key goals of contemporary schooling. In Australia, the National Assessment Program – Literacy and Numeracy (NAPLAN) tests have assessed these skills since 2008. Previous research found a significant gender gap in favour of females for the NAPLAN writing test, yet no study has examined whether gender gaps exist for reading and numeracy or their developmental pattern across the school years. Given the educational and public interest in NAPLAN and its considerable costs, it is important to understand what these tests reveal about student outcomes. The paper presents the first investigation of patterns of male and female student achievement on the NAPLAN reading and numeracy tests from 2008 to 2021. It applies the equivalent year level technique to explain the pedagogical significance of NAPLAN achievement and compares the findings with the writing gender gap to present a fuller picture of male and female achievement.
Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy
Authors: Viol Fabrice , Sipos Bence , Fahl Martina , Clauditz Till S. , Amin Tania , Kriegs Malte , Nieser Maike , Izbicki Jakob R. , Huber Samuel , Lohse Ansgar W. , Schrader Jörg 
Published: October 2022

Abstract
Purpose
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) form a rare and remarkably heterogeneous group of tumors. Therefore, establishing personalized therapies is eminently challenging. To achieve progress in preclinical drug development, there is an urgent need for relevant tumor models.

Methods
We successfully established three gastroenteropancreatic neuroendocrine tumor (GEP-NET) cell lines (NT-18P, NT-18LM, NT-36) and two gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) cell lines (NT-32 and NT-38). We performed a comprehensive characterization of morphology, NET differentiation, proliferation and intracellular signaling pathways of these five cell lines and, in addition, of the NT-3 GEP-NET cell line. Additionally, we conducted panel sequencing to identify genomic alterations suitable for mutation-based targeted therapy.

Results
We found that the GEP-NEN cell lines exhibit a stable neuroendocrine phenotype. Functional kinome profiling revealed a higher activity of serine/threonine kinases (STK) as well as protein tyrosine kinases (PTK) in the GEP-NET cell lines NT-3 and NT-18LM compared to the GEP-NEC cell lines NT-32 and NT-38. Panel sequencing revealed a mutation in Death Domain Associated Protein (DAXX), sensitizing NT-18LM to the Ataxia telangiectasia and Rad3 related (ATR) inhibitor Berzosertib, and a mutation in AT-Rich Interaction Domain 1A (ARID1A), sensitizing NT-38 to the Aurora kinase A inhibitor Alisertib. Small interfering RNA-mediated knock down of DAXX in the DAXX wild type cell line NT-3 sensitized these cells to Berzosertib.

Conclusions
The newly established GEP-NET and GEP-NEC cell lines represent comprehensive preclinical in vitro models suitable to decipher GEP-NEN biology and pathogenesis. Additionally, we present the first results of a GEP-NEN-specific mutation-based targeted therapy. These findings open up new potentialities for personalized therapies in GEP-NEN.
Effect of Vanadium Nitride (VN) Particles on Microstructure and Mechanical Properties of Extruded AZ31 Mg Alloy
Authors: Qiu Wei , Xie Wen , Li Qi-Feng , Huang Wei-Ying , Zhou Li-Bo , Chen Wei , Chen Jian , Ren Yan-Jie , Yao Mao-Hai , Xiong Ai-Hu , Zeng Zhuo-Ran 
Published: October 2022

AbstractThe effect of vanadium nitride (VN) particles additives on microstructure and mechanical properties of the extruded AZ31 Mg alloy was systematically investigated. The experimental results revealed that the addition of 0.5 wt% VN decreased the average grain size of AZ31 Mg alloy from 6.4 to 4.9 µm. With the increase in VN content, the refining effect would weaken because excessive VN particles would negatively affect the dynamic recrystallization process of the alloys. The scanning electron microscopy and energy-dispersive spectroscopy indicated that AlN, VN and Al–V–N particles with different morphologies were distributed in the streamline along the extrusion direction during the extrusion process. The mechanical properties of AZ31 Mg alloy vary with the addition of VN. The extruded AZ31 + 0.5 wt% VN Mg alloy possesses an excellent combination of high strength and ductility. The yield strength and ultimate tensile strength of the extruded AZ31 + 0.5 wt% VN Mg alloy were increased without sacrificing ductility. This is mainly due to the grain refinement caused by double-heterogeneous nucleation particles. With a further increase in VN content, the presence of excessive VN particles increases the stress concentration, and the initiation source of microcracks in the alloy during alloy deformation makes the cracks more easily propagated and results in a decrease in the ductility of the extruded alloy.
Informing care through lived experiences: perspectives of consumers and carers regarding dietetic care for eating disorders in Australia
Authors: Heafala Alana , Mitchell Lana J. , Ball Lauren 
Published: October 2022

Abstract
Purpose
Dietitians are important members of eating disorder treatment teams. Previous research indicates little is known about the experience of receiving nutrition care for eating disorders. This study aimed to explore the perspectives of consumers and carers regarding the care received from primary care dietitians for eating disorders.

Methods
This study qualitatively explored the perceptions of individuals aged ≥ 15 years, who (i) identified as having an eating disorder or (ii) had cared for someone with an eating disorder, and had received care from a dietitian in a primary care setting. Thematic analysis was used to identify themes from interview transcripts. Synthesized member checking was utilized to assess whether the identified themes resonated with participants’ experiences. Twenty-four individuals (21 consumers, 3 carers) participated in a semi-structured interview. Seventeen participants completed member checking and all supported the identified themes and subthemes.

Results
Three themes emerged inductively from the data: (1) valuing a person-centered approach to dietetic care; (2) the therapeutic alliance is central to engaging in dietetic care; and (3) sharing the complex journey.

Conclusions
This study advances the understanding of the aspects of dietetic care perceived as most helpful by consumers and carers. These insights highlight the importance of person-centeredness, empathy, trust and collaboration within eating disorder care. The findings can be used by dietitians and health professionals to inform practice. Further research is needed to understand how dietitians can be supported to provide optimal nutrition care to people and families impacted by eating disorders.

Level of evidence
V. Qualitative study.
No elevated levels of orthorexic eating behavior in a sample of adults with allergies and food intolerances
Authors: Barthels Friederike , Bamberg Leonie , Pietrowsky Reinhard 
Published: October 2022

Abstract
Purpose
To compare orthorexic eating behavior in a sample of adults with and without self-reported allergies and food intolerances.

Methods
N = 52 individuals with and n = 102 individuals without self-reported allergies and food intolerances (80% with medical diagnosis; in total 74.6% female, 23.7% male; age: M = 28.13, SD = 11.96 years) completed an online survey with the Düsseldorf Orthorexia Scale and answered several questions regarding their allergies/intolerances.

Results
The groups did not differ in their orthorexic eating behavior. In the sample of individuals with allergies/intolerances, orthorexic eating behavior correlated with the perceived severity of the allergic symptoms and the number of consequences that the allergies had for eating behavior.

Conclusions
In line with previous findings, orthorexic eating behavior does not seem to be elevated in individuals with allergies/intolerances. However, focusing on a healthy diet despite adverse food reactions and experiencing a number of allergy-related consequences for one’s eating behavior might be associated with orthorexic eating behavior.

Level of evidence
III, case–control analytic study.
Congenital adrenal hyperplasia in patients with adrenal tumors: a population-based case–control study
Authors: Sahlander F. , Patrova J. , Mannheimer B. , Lindh J. D. , Falhammar H. 
Published: October 2022

Abstract
Purpose
Congenital adrenal hyperplasia (CAH) has been associated with adrenal tumors (ATs) but the relationship is still unclear. The aim was to investigate if CAH was more common in patients with adrenal tumors and their characteristics.

Methods
Using national registers all patients with an AT diagnosis (cases) and selected matched controls without AT diagnosis were included from 1st January 2005 to 31st December 2019. The patients with a CAH diagnosis were scrutinized in detail.

Results
ATs were diagnosed in 26,573 individuals and in none of 144,124 controls. In 20 patients with ATs and 1 control, a CAH diagnosis was present. The odds for having CAH in patients with ATs was 109 (95% CI 15–809; P < 0.0001). Among cases, 5 had a CAH diagnosis before the discovery of ATs and 15 afterwards. Half were females and two had been screened for CAH neonatally. The mean age when the ATs was discovered was 55.6 years. Adrenalectomy was performed in seven patients. Five patients had unilateral adrenalectomy before the CAH diagnosis and did not have any glucocorticoid protection. After the CAH diagnosis, 15 were initiated on glucocorticoids and 6 on mineralocorticoids. The majority diagnosed with CAH before index date had classic CAH. In individual diagnosed after index date, only three had classic CAH. The rest had nonclassical CAH. During the follow-up time of 9 years, six deceased, two of them in an adrenal crisis.

Conclusions
The prevalence of CAH was greater in patients with ATs than in patients without. In all patients with ATs, CAH should be considered.
The Gender Gaps in Time-Use Within Italian Households During 2002–2014
Authors: Barigozzi Francesca , Di Timoteo Cesare , Monfardini Chiara 
Published: October 2022

AbstractHow are Italian parents sharing family duties when they are both working full-time? We estimate gender gaps in the allocation of time by young Italian couples with children and document their trends over the years 2002–2014, disentangling time use on weekdays and weekend days. We show that the gaps in time devoted to Market work and Household work have narrowed over the years 2002–2014, while the gap in Basic childcare and Leisure remained almost constant. But the negative gap (females-males) in Market work shrunk much more than the positive gap in Household work (46% against 25%) The best-case scenario for gender parity is the one in which partners share similar work responsibilities and are relatively young; however, we show that family duties remain heavily unbalanced across gender in this sample. In 2014, full-time working mothers devote to Total work (paid and unpaid) 11 h per week more and to Leisure 9.7 h per week less than their partners. On the positive side, the gender gap in Quality childcare exhibits a reversed sign, which is driven by fathers’ engagement on weekend days.
“Reading Enjoyment” is Ready for School: Foregrounding Affect and Sociality in Children’s Reading for Pleasure
Authors: Boyask Ruth , Harrington Celeste , Milne John , Smith Bradley 
Published: October 2022

AbstractWhile debate on declines in children’s literacy is ongoing in Aotearoa New Zealand, very little attention in research and policy is paid to reading enjoyment and its capacity to support the reading development of children. Developed alongside a series of studies on children’s reading for pleasure this article makes a theoretically informed argument to place reading enjoyment at the centre of literacy education in schools. Our argument is underpinned by a psycho-social conceptualisation of enjoyment that emphasises the fundamental sociality of emotion. Foregrounding affect and sociality in children and young people’s reading speaks to the potential of teachers being with childrenandtheir whānau together reading for pleasure. When children are at school they can participate in the sociality of reading for pleasure, sharing its enjoyment with other class members and teachers without coming into conflict with the priorities of life outside of school. If schools embed reading enjoyment in their programmes, they might then have greater capacity to follow the literacy and communication strategy and work towards sharing the collective enjoyment of reading with families, whānau, and communities.
A second demographic transition in Indonesia?
Authors: Utomo Ariane , Ananta Aris , Setyonaluri Diahhadi , Aryaputra Calvin 
Published: October 2022

AbstractAs a predominantly Muslim and ethnically diverse new democracy in Asia, Indonesia is a timely case to study how the contending forces of development and social change are reflected in changing norms and practices around family formation. This paper examines the extent to which the second demographic transition (SDT) theory can provide a primary framework to understand contemporary patterns of fertility, marriage and family change in Indonesia. Against the backdrop of socio-political change followingReformasi in1998, we found emerging demographic features typically associated with societies in later stages of fertility transition. These include fertility below replacement in some regions; increasing age at first marriage, non-marriage, and divorce rates; and growing diversity in household/family forms. As the vast regions of Indonesia is economically, culturally, and demographically heterogeneous, these key features of SDT are not likely to emerge and unfold in a uniform manner. Further, these demographic shifts are taking place amidst multiple tensions and contradictions in the nature and direction of ideational change pertaining to marriage and the family. We argue that the prevailingideational changedriving the shifts in marriage, fertility, and the family within Indonesia is neither unilinear nor singular in nature. Emerging ideational change embodying individualism, secularism, and post-materialism—originally proposed in SDT theory to be the primary drivers of fertility decline in post-industrial Western Europe—can overlap with popular values promoting de-secularization and the strengthening of familial institutions. As a demographic framework, the SDT theory is an important and useful starting point. But it needs to be reevaluated by considering the complex socio-political and increasingly precarious economic terrains behind fertility transition, as well as marriage and family change in post-ReformasiIndonesia.