bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying and understanding disease burden in patients with inflammatory bowel disease on biological therapy
Authors: Christensen Katrine Risager , Ainsworth Mark Andrew , Skougaard Marie , Steenholdt Casper , Buhl Sine , Brynskov Jørn , Kristensen Lars Erik , Jørgensen Tanja Schjødt 
Published: April 2022

Abstract
Background: Physicians tend to focus on biomedical targets (endoscopic remission), while little is known about issues important to patients. We aimed to identify critical concepts impacting inflammatory bowel disease (IBD) patients.Methods: We performed a survey of patients with IBD in biologic therapy (n=172) and used a validated qualitative method called concept mapping (CM) in patient workshops. The survey included 13 questions on attitudes toward symptoms and issues related to IBD. In the eight CM workshops, patients (n=26) generated statements later clustered into concepts identifying issues impacting a patient’s life. Patients ranked the statements by importance.Results: In the questionnaire survey, patients identified fatigue (57%) and stool frequency (46%) as the most critical symptoms impacting their daily lives regardless of disease activity. In the CM workshops with Crohn’s disease (n=13), 335 statements divided among ten concepts were generated, and the three most important concepts were “Positive attitudes,” (mean 4.3) “Accept and recognition” (mean 4), and “Personal experiences with Crohn’s disease,” (mean 4). In the workshops with ulcerative colitis (n=13), 408 statements divided into 11 concepts were generated; the most important concepts were “Take responsibility and control over your life” (mean 4), “Medication” (mean 3.9), and “Everyday life with ulcerative colitis” (mean 3.7)Conclusion: While symptoms such as fatigue and stool frequency impacted daily life regardless of disease activity, patients with IBD rated concepts focusing on psychosocial factors as having the most significant impact on everyday life.Trial registration: The Copenhagen University Hospital, Herlev and Gentofte approved the questionnaire and methodology (work-zone no.: 18015429).
Naringenin improves muscle endurance via activation of the Sp1-ERRγ transcriptional axis
Authors: lv Zhenyu , Meng Jiao , Yao Sheng , Xiao Fu , Cui Chen , Chen Kaixian , Luo Xiaomin , Ye Yang , Chen Chang 
Published: April 2022

Abstract
Skeletal muscle function declines in aging process or disease; however, until now, skeletal muscle has remained one of the organs most undertreated with medication. In this study, naringenin (NAR) was found to build muscle endurance and ameliorate muscle dysfunction during aging and in mdx mice by increasing oxidative myofiber numbers and aerobic metabolism. The transcription factor Sp1 was identified as a direct target of NAR and approved to mediate the function of NAR according to the results that Sp1 deficiency suppressed the benefit effect of NAR. Moreover, the binding site was further validated to be GLN-110. NAR enhances the binding of Sp1 to the CCCTGCCCTC sequence of the Esrrg promoter by promoting Sp1 phosphorylation, thus upregulates Esrrg expression. The discovery of the Sp1-ERRγ transcriptional axis is of great significance in basic muscle research, and the new function of NAR has potential implications for the prevention of age-or disease-related muscle atrophy.
In utero Repair of Myelomeningocele with Bovine Pericardial Patch. Case Report
Authors: Talabaev Mikle , Venegas Kevin , Beluga Maxim , Vasiljev Sergei , Bogomolov Alexandr , Salauyeva Hanna 
Published: April 2022

Abstract
We present the first case of meningomyelocele (MMC) in utero repair with the bovine pericardial patch performed in Belarus. We followed the maternal and fetal inclusion and exclusion criteria used by the MOMS trial. Prenatal fetal magnetic resonance imaging (MRI) shows the anomaly of cerebellar tonsils, brain stem herniation and MMC at the level of L5-S1 vertebra. During the standard surgical hysterectomy, we performed exposure of the fetus and applied microsurgical repair of the MMC defect with the use of bovine pericardial patch. In our case, we demonstrated the use of bovine pericardial patch for MMC defect repair as optimal and safe material which resulted into skin epithelialization by the first month of life.
Ticagrelor alleviates pyroptosis in myocardial ischemia reperfusion-induced acute lung injury
Authors: Dai Yi-Ning , Wang Li-Tao , Zhang Ye-Shen , He Peng-Cheng , Tan Ning , Liu Yuan-Hui 
Published: April 2022

Abstract
Background: Pulmonary infection is highly prevalent in patients with acute myocardial infarction undergoing percutaneous coronary intervention. However, the potential mechanism is unknown. Myocardial ischemia-reperfusion injury (MIRI) was shown to induce acute lung injury (ALI) related to pulmonary infection and inflammation. Whether MIRI induces pyroptosis in the lungs remains unclear. Method: Sprague-Dawley rats were randomly divided into four groups: control, MIRI, low ticagrelor (30 mg/kg), and high ticagrelor (100 mg/kg). Rats were treated with ticagrelor or saline via intragastric gavage before undergoing surgery. Serum parameters of CK-MB and LDH were measured using automatic biochemistry analyzers. HE staining to obtain HE scores was performed following the calculation of the wet-to-dry ratio. NLRP3, ASC, and cleaved caspase-1 in lung tissue were detected by western blot, and IL-1β was assessed by ELISA. Immunohistochemistry was used to determine the MPO+, NLRP3+, and cleaved caspase-1+ area. Results: The HE score, wet-to-dry ratio, and MPO+ area were increased in the MIRI group, and attenuated after ticagrelor treatment. Pyroptosis-associated proteins including NLRP3, ASC, and cleaved caspase-1 were elevated in MIRI, and eliminated by ticagrelor. Similar results were observed using immunohistochemistry assays. Conclusions: Pyroptosis was augmented in lung tissue after MIRI, and pre-treatment with ticagrelor attenuated these effects.
Performance Evaluation of Bimetallic Surface Plasmon Resonance Biosensor Based on Copper and MXene(Ti3C2Tx)
Authors: Wei Kaihua , Su Xianglong , Zhang Libin , Wu Pinghui , Zhu Hairong , Wu Kaihua , Guo Yan 
Published: April 2022

Abstract
Copper having high electrical conductivity can be a candidate for the plasmonic metal. MXene (Ti3C2Tx) is an emerging two-dimensional material can be used in the biosensing field considering its excellent metallic conductivity and hydrophilic fictionalized surface terminations. Here, we employ copper and nickel as the plasmonic metals and MXene as the sensing interface to achieve significant improvement in sensitivity through angular interrogation. We propose three structures based on bimetallic materials of copper and nickel. Through systematic optimization of all parameters, three optimum sensing configurations from these structures have been achieved, where the highest sensitivity can be obtained is 626 º/RIU with 564% increment compared with that of pure copper-based sensor, and the limit of detection of the refractive index change can be as low as 1.5 × 10− 6 RIU.
Polyvinyl chloride-based dielectric elastomer with high permittivity and low viscoelasticity for actuation and sensing
Authors: Huang Jianjian , Zhang Xiaodie , Liu Ruixue , Ding Yonghui , Guo Dongjie 
Published: April 2022

Abstract
Dielectric elastomers (DEs) have been widely used and shown great promises in soft actuation and sensing applications. However, existing DEs suffer from inherent low permittivity and high viscoelasticity, thus DE actuator requires high driving electrical field and exhibits high mechanical loss and large strain shift. Also, DE sensor exhibits low sensitivity, slow response and large signal drift. To overcome these limitations, this study demonstrates a novel and practical strategy to produce a polyvinyl chloride (PVC)-based elastomer with unprecedented properties, i.e. high permittivity and low viscoelasticity. Specifically, an introduction of cyanoethyl cellulose (CEC) into a plasticized PVC confers a high dielectric permittivity (18.9 at 1kHZ) and low viscoelastic effects with extremely low mechanical loss (tan δ = 0.05 at 1 Hz), which represent 4-fold increase in permittivity and 95% reduction in mechanical loss compared to commercial 3M VHB acrylic elastomer. Moreover, the resulted CEC/PVC DEs demonstrate superior performance in actuation and sensing as compared to the pristine PVC and other commonly used DEs. The CEC/PVC based actuator generates significantly larger strain of 12.22% and blocking force of 300 g under a low electrical field, i.e. 9.09 V/µm. The viscoelastic drift of CEV/PVC based actuator is only 3.5% over 1000 cycles, i.e. 1000 s, which is negligible when compared to 3M VHB based actuator (232.1% drift in 500 s). In addition, the CEC/PVC based sensor shows high sensitivity, stability, and fast response, which enables faithful monitoring of multiple human motions. The reported strategy can be readily applied and will be an asset to many applications, such as artificial muscle and electronic sensory skin.
Application of 9.4 Tesla resting-state functional MRI to Assess Neuronal function and Detect Microglial Density in AKI Rat Model
Authors: Yu Ziyang , Pang Huize , Yang Yifan , Xu Chenxi , Zheng Haiping , Huang Zicheng , Wu Ziqian , Hu Jingyi , Ren Ke 
Published: April 2022

Abstract
Background
Converging evidence increasingly implicates acute kidney injury (AKI) contribute to a series of brain injury. However, the neurobiological mechanisms of AKI induced brain alterations remains unclear. Examining the neurobiology of AKI induce brain injury and an early detection using non-invasive imaging method is critical for the early diagnosis and target treatment.
Methods
The AKI Sprague-Dawley male rats and the healthy control group performed the Morris water maze and acquired rs-fMRI images with 9.4-Tesla Bruker BioSpec system at 24, 48 and 72 hours following administering contrast medium or saline. Whole brain amplitude of Low-Frequency Fluctuations (ALFF) at each time course was compared among groups. The AKI rats were then euthanized immediately, followed by H&E staining and immunohistochemistry (IHC). Besides, Flow cytometry analysis, Western blotting and immunofluorescence were performed to evaluate neuron and activated microglia.
Results
In contrast to HC group, lower ALFF in bilateral Cornu Ammonis (CA1) were observed in AKI-CI group. Specifically, there were significant differences in the ALFF values in the CA1 between the 48 h and 72 h in AKI groups. In addition, the percentages of microglia increased in AKI group at 24 h (range from 15.07 to 41.70%) and dramatically increased after 24h (range from 41.70–82.57%). Moreover, quantitative Flow cytometry analysis of microglial proportion is strongly correlated with the mALFF value (|r|༞0.80, P༜0.001).
Conclusions
Aberrant functional activity in the hippocampus, mainly CA1, contributes to the AKI induced brain injury. The ALFF of hippocampus may be an effective imaging biomarker for detecting grading of microglial proportion and have implications for early target treatment.
Economic Income and Life Satisfaction of Rural Chinese Older Adults: The Effects of Physical Health and Ostracism
Authors: Wang Yichen , Zhang Denghao 
Published: April 2022

Abstract
Purpose
This study aims to explore the serial mediating effect of physical health and ostracism between economic income and life satisfaction.
Methods
The study data was taken from the large cross-sectional survey: “Thousands of People and Hundreds of Villages (2019)”. A total of 1514 rural older adults were included in the analyses. Ostracism was assessed using the Ostracism Experience Scale (OMES), and life satisfaction was assessed using the Life Satisfaction Scale (LSS).
Results
The results showed that (1) economic income is positively related to the life satisfaction of rural older adults, and (2) physical health and ostracism experiences serially mediated the relationship between income and life satisfaction.
Conclusion
Thus, this study confirmed the serial mediating effect of health and ostracism between income and life satisfaction.
Trends in Psychiatric Admissions of Children and Adolescents During Early Corona Period Year (2020) Compared to Pre-Corona Year (2018): A Cross Sectional Study in Israel
Authors: Saad Ali , Hamady Hadeel , Kronos Tanya , Sandler Ludmila , Itah Dorit 
Published: April 2022

Abstract
Background: the current study sought to assess the patterns and characteristics of psychiatric admissions among children and adolescents during the early corona period (2020) compared to a year before the corona pandemic started (2018), and analyzing on a deeper level the psychiatric admissions that were related directly to corona stressors and their correlations with sociodemographic variables.Method: a cross-sectional study was conducted in The Child and Family Guidance Unit in The Galilee Medical Center, a psychiatric department for patients aged 6-18 years. The medical records of psychiatric admissions in the year 2020 and 2018 were analyzed on the same dates. Statistical analyses were performed with SPSS v.20. Since all the variables were not normally distributed according to Shapiro-Wilk, non-parametric tests were conducted, including Mann-Whitney U and Chi-Square tests.Results: the study showed 17% increase in psychiatric admissions in 2020 compared with 2018. In 2018 most admissions were at November while in 2020 most of them were at May. The most common cause of admissions in 2018 was outbursts and violence 43% while in 2020 it was suicidal thoughts and behaviors 36%. Almost a third of patients admitted in 2020 reported a corona stressor in their admission, the majority was changes in daily routines. Conclusion: Changing daily routine and inconsistency in school attendance may have been the main stress factor on children and adolescents and might have caused a rise in hospital admissions caused by suicidal thoughts and behaviors. Thus, future studies should monitor the mental health of children and adolescents during the continual corona pandemic.
Risk factors for remnant gastric cancer after distal gastrectomy for gastric cancer: a retrospective database review
Authors: Sakamoto Shinya , Wada Ikuo , Omichi Kiyohiko , Furuke Shunsaku , Kitnai Yusuke , Takegami Masayuki , Nasu Keiichi , Inada Kentaro , Takahama Yukiko , Takahashi Michiro , Imamura Kazuhiro , Maeshiro Tsuyoshi 
Published: April 2022

Abstract
Background: The number of patients with remnant gastric cancer (RGC) following gastrectomy for gastric cancer (GC) is increasing due to the increasing number of patients undergoing function-preserving gastrectomy and improved outcomes for patients with GC. Male sex, old age, intestinal type, tumor depth, and synchronous multiple GC were all associated with RGC development in a few studies with a small number of cases. However, the risk factors for RGC development remain unclear. This study aimed to examine the clinicopathological features of patients with GC; these patients were followed up after they underwent distal gastrectomy and the potential risk factors for RGC development were evaluated.Methods: A retrospective database review of 438 patients who underwent distal gastrectomy for GC at a single institution, from 2006 to 2017, was conducted. We used Cox proportional hazards analysis to estimate the relationship between clinicopathological features, operative findings, and postoperative course with RGC development. The cumulative incidence rates of RGC were calculated using the Kaplan–Meier method.Results: We retrospectively analyzed 405 cases. The median patient age was 69 years, and the patient cohort consisted of 263 men and 142 women. The Billroth-I reconstruction method was used in 204 cases, the Billroth-II method was used in 3 cases; the Roux-en Y method was used in 198 cases. RGC was diagnosed in 11 of the 405 patients. The median follow-up period was 5 years. The cumulative incidence rates of RGC calculated using the Kaplan–Meier method were 3.0%, 4.1%, and 9.1% at 5, 10, and 15 years after distal gastrectomy, respectively. During the initial surgery, intestinal-type GC was significantly associated with RGC development (hazard ratio [HR], 4.71; 95% confidence interval [CI], 1.02–21.80; p = 0.05). Male sex (HR, 2.97; 95%CI, 0.64–13.75; p = 0.16), old age (≥70) (HR, 2.72; 95%CI, 0.78–9.47; p = 0.11), and synchronous multiple GC (HR, 1.31; 95%CI, 0.28–6.08; p = 0.37) were not associated with RGC development.Conclusions: Distal gastrectomy for intestinal-type GC was significantly associated with RGC development. Hence, patients who underwent distal gastrectomy for intestinal-type GC would require intensive endoscopic surveillance.
Interest of Thoracic Trauma Severity (TTS) score for predict acute respiratory failure after mild blunt chest trauma : result of an observational study
Authors: Coularet Charlotte , Carvelli Julien , Gainnier Marc , Bouzana Fouad , Lesaux Audrey , Boucekine Mohamed , David Tonon , Cauchoix Emi , Bichon Amandine , Michelet Pierre , Bourenne Jeremy 
Published: April 2022

Abstract
Introduction: Non-life-threatening blunt chest trauma (BCT) admitted in emergency department (ED) are at risk of acute respiratory failure (ARF) and respiratory complications during their intensive care unit (ICU) follow-up. They may require a special focus to adopt specific prophylactic strategies and proper orientation. The aim of this study was to identify different risk factors for ARF in mild BCT.Methods: This retrospective, monocentric study from January 2015 to December 2020 included all patients with mild BCT admitted to the ED and managed in ICU for at least 48 hours with spontaneous breathing at admission. Occurrence of ARF was defined by PaO2/FiO2 ratio (PaFI) under 200 and need of ventilator support in the first 72 hours after admission. Using univariate and multivariate analysis, the risk factors of ARF incidence after BCT were investigated. We also studied the global ability of the TTS score to predict ARF occurrence by a ROC curve. Finally, we assessed the most significant and sensitive TTS score threshold. Results: A total of 190 BCT patients was included and 23.7% of them developed an ARF. A TTS score greater than 8 was independently associated with early ARF. A TTS score threshold of 6 significantly predicted the ARF incidence with a sensitivity (91%) and negative predictor value (94%) in mild BCT. The others risk factors independently associated with ARF were chronic respiratory disease, high score SOFA and loco regional analgesia.Conclusion: A significant amount of risk factors of ARF following mild BCT were highlighted in our study and must be considered for the proper management of those patient. It is the first study to enhance that a low TTS score threshold could help the mass screening and proper orientation of mild BCT. This study provides the basis for the development of a new risk stratification tool (TTS score) for mild BCT patients who may develop respiratory complications.
Morphometric analysis of the cervical intervertebral foramina: Establishment of a normative database in Jordanians using 3-D reconstructed computed tomography images
Authors: Momani Esraa A. , Ghaida Jamal H. Abu , Marashdeh Wael , Aldaoud Osamah , Al-Mousa Arwa A. , Bataineh Ziad 
Published: April 2022

Abstract
Purpose
Despite overwhelming clinical importance, no accurate threshold values of linear measurements of cervical intervertebral foramina exist that signify the switch of cases from asymptomatic to symptomatic state. The pattern of change of relevant morphometric values with regard to different parameters remain inconclusive. In Jordan, morphometric analysis of normal cervical intervertebral foramina is still absolutely lacking. We intend to establish a normative database of the linear measurements of the cervical intervertebral foramina in a representative sample of normal Jordanian population. Age-, gender-, vertebral level-, and laterality-dependent differences of these measurements are to be explored.
Methods
Parasagittal computerized tomographic images of 320 normal Jordanians, 16–37 years of age, were stratified according to age and gender, three-dimensionally reconstructed, and foraminal height and width at the levels C2/C3 through C7/T1 were bilaterally measured and statistically analyzed.
Results
The overall average foraminal height and foraminal width measured: 10.15, 8.09, 8.00, 8.18, 8.43, and 7.97, and 6.34, 5.73, 6.03, 6.11, 6.83, and 7.33 (in mm), for the levels C2/C3 through C7/T1, respectively with mean ratio Width/Height was 0.77. A consistent reciprocal cranio-caudal pattern of decrease of height and increase of width was evident. Males showed consistently higher height and width values with level of significance reached at upper and lower intervertebral levels. Although statistically insignificant, the Adolescent age group showed the highest values of height and width among all other age groups. Significant side-related differences were lacking.
Conclusions
The linear parameters of normal cervical intervertebral foramina in Jordanians correspond well with other published studies, and follow differential, gender- and age-dependent, craniocaudal pattern of change relative to multiple variables.
BRANEnet: Embedding Multilayer Networks for Omics Data Integration
Authors: Jagtap Surabhi , Pirayre Aurélie , Bidard Fréderique , Duval Laurent , Malliaros Fragkiskos D. 
Published: April 2022

Abstract
Background: Gene expression is regulated at different molecular levels, including chromatin accessibility, transcription, RNA maturation, and transport. These regulatory mechanisms have strong connections with cellular metabolism. In order to study the cellular system and its functioning, omics data at each molecular level can be generated and efficiently integrated. Here, we propose BRANEnet, a novel multi-omics integration framework for multilayer heterogeneous networks. BRANEnet is an expressive, scalable, and versatile method to learn node embeddings, leveraging random walk information within a matrix factorization framework. Our goal is to efficiently integrate multi-omics data to study different regulatory aspects of multilayered processes that occur in organisms. We evaluate our framework using multi-omics data of Saccharomyces cerevisiae, a well-studied yeast model organism. Results: We test BRANEnet on transcriptomics (RNA-seq) and targeted metabolomics (NMR) data for wild-type yeast strain during a heat-shock time course of 0, 20, and 120 minutes. Our framework learns features for differentially expressed bio-molecules showing heat stress response. We demonstrate the applicability of the learned features for targeted omics inference tasks: transcription factor (TF)-target prediction, integrated omics network (ION) inference, and module identification. The performance of BRANEnet is compared with existing network integration methods. Our model outperforms baseline methods by achieving high prediction scores for a variety of downstream tasks.