bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation in Atrial Fibrillation Associated with Mitral Stenosis
Authors: da Silva Rose Mary Ferreira Lisboa 
Published: March 2022

Abstract:
Rheumatic valve disease is present in 0.4 % of the word population, mainly in lowincome
countries. Rheumatic mitral stenosis affects more women and between 40 to 75 % of patients
may have atrial fibrillation (AF), more frequently in upper-middle income countries. This
rhythm disturbance is due to increased atrial pressure, chronic inflammation, fibrosis, and left atrial
enlargement. There is also an increase in the prevalence of AF with age in patients with mitral
stenosis. The risk of stroke is 4 % per year. Success rates for cardioversion, Cox-Maze procedure,
and catheter ablation are low. Therefore, anticoagulation with vitamin K antagonist is mandatory
for Evaluated Heart valves, Rheumatic or Artificial (EHRA) classification type 1. However, this
anticoagulation is used by less than 80 % of those eligible and less than 30 % have the international
normalized ratio in the therapeutic range. The safety and efficacy of using rivaroxaban, a direct
factor Xa inhibitor anticoagulant, were demonstrated in the RIVER trial with a sample of 1005
patients with AF and bioprosthetic mitral valve. The indication for valve replacement, that is, if
severe mitral stenosis or severe mitral regurgitation, was not specified. A randomized, open-label
study (DAVID-MS) is underway to compare the effectiveness and safety of dabigatran and warfarin
therapy for stroke prevention in patients with AF and moderate or severe mitral stenosis. Thus,
the applicability of the use of direct anticoagulants in patients with AF and mitral stenosis and also
in those undergoing mitral bioprostheses surgery will be the subject of further studies. The findings
may explain if specific atrial changes of mitral stenosis even after the valve replacement will influence
thromboembolic events with direct anticoagulants.
Biological Importance of a Biflavonoid ‘Bilobetin’ in the Medicine:
Medicinal Importance, Pharmacological Activities and Analytical Aspects
Authors: Patel Dinesh Kumar 
Published: March 2022

Background:
Flavonoid class phytochemicals are natural compounds present in different
medicinal plants, vegetables and fruits. Ginkgo biloba contains significant amounts of bioflavonoid
‘bilobetin’. Bilobetin is an active phytochemical used for the treatment of human health complications
due to its medicinal properties and therapeutic benefit. The purpose of this work is to collect and
reviewed scientific data on bilobetin from different literature sources; highlight their biological
properties, pharmacological activities and analytical aspects.

Methods:
Health beneficial aspects of bilobetin have been investigated in the present work through
scientific data analysis. PubMed, Google Scholar, Google, Scopus, etc. have been searched in the present
work in order to collect scientific information on bilobetin. Medicinal importance and therapeutic
benefit of bilobetin has been searched in the present work through these databases of bilobetin. Detailed
pharmacological activities of bilobetin have been reviewed in the present work through literature
data analysis of various scientific research works. However, analytical data of bilobetin were also collected
and reviewed in the present reaserch.

Results:
Literature data analysis of bilobetin in the present work revealed the medicinal properties and
therapeutic potential of bilobetin mainly due to its anti-fungal, anti-inflammatory, anti-oxidant, antihyperlipidemic,
and anti-proliferative activities. Literature data analysis revealed the effectiveness of
bilobetin on osteoporosis, glucose metabolism, adipocytes, SARS CoV-2, Influenza A virus and human
thrombin. Scientific data also revealed the importance of different analytical techniques for the
isolation, separation, identification, and quantification of bilobetin.

Conclusion:
Scientific data analysis revealed biological importance and pharmacological activities of
bilobetin in the health sector.
An Updated Review on Complicated Mechanisms of COVID-19 Pathogenesis
and Therapy: Direct Viral Damage, Renin-angiotensin System
Dysregulation, Immune System Derangements, and Endothelial Dysfunction
Authors: Falahi Shahab , Maleki Maryam , Kenarkoohi Azra 
Published: March 2022

Abstract:
SARS-CoV-2 was reported as the cause of coronavirus disease 2019 (COVID-19) in late
December 2019. According to sequencing and phylogenetic studies, the new virus belongs to Coronaviridae
family and Betacoronavirus genus. Genomic sequence analysis has shown SARS-CoV-2 to
be similar to SARS. SARS-CoV-2 is more infectious, and the high level of COVID-19 community
transmission has led to a growing pandemic. Although infections in most patients with COVID-19 are
moderate or mild, 20% of the patients develop a severe or critical form of the disease. COVID-19 may
affect a wide range of organs and tissues, including the respiratory system, digestive system, nervous
system, and skin. Patients with COVID-19 have been confirmed to have renal, cardiovascular, gastrointestinal,
and nervous system problems in addition to pulmonary involvement. The pathogenesis of
SARS-CoV-2 is being investigated, but it is possible that the organ damage might in part be caused by
direct viral damage (detection of inclusion bodies in tissues, such as the kidneys), dysregulation of the
immune system, renin-angiotensin system, bradykinin pathway, and coagulation, as well as host genetic
factors and their polymorphisms, which may affect the disease severity. In this review, an update on
the possible pathogenesis pathways of COVID-19 has been provided. It is hoped that the best care
strategy will be developed for patients with COVID-19 by identifying its pathogenesis pathways.
Powerful Stress Relieving Medicinal Plants for Anger, Anxiety,
Depression, and Stress During Global Pandemic
Authors: Shahrajabian Mohamad Hesam 
Published: March 2022

Abstract:
Consideration and improvement for anxiety and depression are important during
a global pandemic. Appropriate healthcare can be obtained by paying more attention to
traditional medicinal sciences. The adverse effects of stress with various symptoms can be
managed by introducing plants that boost mental health. The most relevant psychological
reactions in the general population related to the global pandemic are pervasive anxiety,
frustration and boredom, specific and uncontrolled fear, disabling loneliness, significant
lifestyle changes, and psychiatric conditions. Ginseng, chamomile, passionflower, herbal
tea, lavender, saffron, kava, rose, cardamom, Chinese date, and some chief formula like
yokukansan, Dan-zhi-xiao-yao-san, so-ochim-tang-gamiband, and saikokaryukotsuboreito
are notable herbal treatments for mental health problems. The most common medicinal
plants that have been used in Iran for the cure of stress and anxiety are Viper’s-buglosses,
Dracocephalum, valerian, chamomile, common hop, hawthorns, and lavender. Medicinal
plants and herbs can be used for the treatment and alleviation of the negative effects of
stress, anger, and depression during the global pandemic.
New, Fast, and Sustainable Method by HPLC for Simultaneous Determination
of Ascorbic Acid and Nicotinamide in the Study of Cosmetic Emulsions
Authors: Spagnol Caroline Magnani , Martins Camila Jandira , Kogawa Ana Carolina , Isaac Vera Lucia Borges , Salgado Hérida Regina Nunes , Corrêa Marcos Antonio 
Published: March 2022

Aims:
This study aimed to develop a new, fast and sustainable method by high-performance liquid chromatography (HPLC) for simultaneous determination of ascorbic acid and nicotinamide in the cosmetic emulsion.

Background:
Nicotinamide (NIC) and ascorbic acid (AA) are powerful antioxidants. AA presents excellent reducing power and protects the cell from oxidation. NIC is a precursor of NADPH and NADH, substances that present a strong reduction power, resulting in a huge antioxidant capacity.

Objective:
A new, fast and sustainable method using HPLC was developed and validated for simul-taneous quantification of AA and NIC in the cosmetic emulsion.

Method:
For this purpose, purified water with 0.01 % of trifluoracetic acid and ethanol (95:5, v/v), Symmetry Shield column (4.6 x 250 mm, 5 μm), 20 μL, 1.7 mL min-1 at 254 nm were used. The method was validated according to the ICH, AOAC, and ANVISA, following parameters of lineari-ty, detection and quantification limits, selectivity, accuracy, precision, and robustness.

Result:
The method was fast (2.7 min for AA and 3.2 min for NIC), linear between 20 and 80 μg mL-1 (r = 0.9991 for AA and r = 0.9999 for NIC), precise (RSD< 5 % for AA and NIC), accurate (RSD 0.53 % for AA and 1.02 % for NIC), and selective for the emulsion base, and also robust to small changes in flow rate, injection volume, and purified water source.

Conclusions:
This work shows an ecologically alternative for the quantification of AA and NIC in the study of cosmetic emulsion by HPLC, which contemplates the requirements of the current green and sustainable analytical chemistry.
Using Psychedelics in Clinical Practice: Comparing Therapeutic Uses and Potential Harms
Authors: Tariq Rabeet 
Published: March 2022

Abstract:Psychedelics might be the oldest psychoactive agents known to be used for inducing religious or mystical experiences. Their strong psychoactive effect was discovered accidentally in 1943 after the synthesis of Lysergic acid diethylamide (LSD) in 1937. These drugs became a mainstream area of research following the synthesis of LSD; however, several political and social factors led to their ban in 1966, after which research on psychedelics remained limited. These drugs became a major topic of scientific and ethical debate in the 1990’s and the recent times have seen a ‘Psychedelic renaissance’ where the therapeutic value of psychedelics is being reconsidered. This article reports the historical perspective of psychedelics, pharmacologic action by 5-HT2A receptor agonism, and psychological effects and compares the proposed therapeutic uses, including uses in depression, PTSD, anxiety- related disorders, drug and alcohol addiction, neurodegenerative diseases, and auto-immune diseases to potential harms including the development of tolerance, hallucinogen persisting perception disorder, and potential psychosis. An analysis of history, pharmacology, and comparison of benefits and harms lead to the conclusion that the potential therapeutic benefits significantly outweigh the potential harms; thus, further research and clinical trials need to be conducted across different countries and cultures for their legal approval in clinical use.
Detección de Agave angustifolia y Agave cupreata con técnicas geomáticas en Guerrero, México
Authors: Olvera-Vargas Luis Alberto , Pardo-Nuñez Joaliné , Aguilar-Rivera Noé , Contreras-Medina David Israel 
Published: March 2022

La planta del agave tiene un significativo valor económico y cultural, pues no solo se considera un producto agrícola y forestal, sino que además se emplea en la elaboración de una cantidad importante de productos. En México, uno de los derivados más representativos del agave son las bebidas destiladas de mezcal y tequila, cuya venta se ha incrementado fuera del país. En respuesta a esta demanda, Guerrero ha reportado un crecimiento anual de la producción de mezcal del 1,5 %, con un aumento en la superficie de más de 1.000 hectáreas entre 2015 y 2020. Este auge comercial ha generado una expansión e intensificación de la siembra y producción de la Agave spp. (Asparagaceae), así como el uso de técnicas agrícolas de producción inadecuadas y cambios en la tecnología tradicional. Es por ello que el objetivo de este trabajo fue localizar espacialmente el agave mezcal, en particular las especies Agave cupreata Trel. & Berger y Agave angustifolia Haw., con tecnologías geomáticas para identificar los ambientes diversificados del agave (silvestre o cultivado) que fortalezcan los procesos agroproductivos y potencien los subproductos del cultivo. El estudio encontró que la superficie potencial del cultivo de agave es superior a lo reportado por fuentes oficiales en más de 25.000 hectáreas y que los cálculos realizados con tecnologías geomáticas tienen una precisión del 91 % para identificar áreas adecuadas para el aprovechamiento y la conservación de estas dos especies de importancia económica.
Online Knowledge Translation Program Involving Video Games and University Student–Led Tutorials About Cannabis and Psychosis for Black Youth: Mixed Method Feasibility Study
Authors: Jani Payal , Song Nuri , Artna Erin , Lyeo Joonsoo , Assam Ashley , Maelzer Faith , Murphy Andriene , Grant Angelo , Archie Suzanne 
Published: March 2022

Background
We have piloted a new online knowledge translation (KT) program created to educate youth about cannabis effects, which uniquely focuses on mental health risks for Black youth. Youth are generally unaware of the research linking underage usage and the risk of psychosis. Youth from some Black racialized communities in Ontario may be disproportionately affected and in need of this knowledge.

Objective
Because very little is known about the acceptability and feasibility of programs educating Black youth about cannabis and psychosis risk, we evaluated this KT program, which consists of tutorials facilitated by university students and video games.

Methods
This mixed methods pilot study evaluates the transfer of knowledge about cannabis and psychosis risk before and after the online KT program and, at the same time, explores participant satisfaction with the program and views about underage use. Eligible participants were youth 16-19 years of age of Black African or Caribbean descent. Trained undergraduate students from McMaster University administered a quiz (psychosis and cannabis test; PCT) to evaluate knowledge before and after the KT program. After playing the psychoeducational video games, participants attended two tutorial group sessions led by undergraduate students. The undergraduate students facilitated the online tutorials about cannabis and psychosis. The tutorials augmented the educational content embedded within the gameplay: participants discussed what they learned from the video games and their understanding of psychosis and the effects of cannabis. In addition, undergraduate students qualitatively analyzed the tutorial discussions for themes, and the prequiz and postquiz scores were analyzed for significant differences in scores.

Results
A total of 9 Black youth were recruited and completed this pilot study. The mean PCT scores were 5.67 (SD 1.7) and 7.78 (SD 1.8) before and after the KT program, respectively. There was a significant improvement in scores (P<.05) post-KT program. Thematic analysis of the facilitated tutorials revealed three major themes: video game satisfaction, marijuana and psychosis literacy, and help-seeking awareness. Overall, participants showed an increased awareness and understanding of the subject matter after the gameplay and tutorial intervention.

Conclusions
When supplemented with tutorial sessions, the Back to Reality Series shows promise for addressing the gap in knowledge about cannabis and psychosis, and the results provide preliminary evidence that the games appeal to Black youth.
Sociotechnical Factors Affecting Patients’ Adoption of Mobile Health Tools: Systematic Literature Review and Narrative Synthesis
Authors: Jacob Christine , Sezgin Emre , Sanchez-Vazquez Antonio , Ivory Chris 
Published: March 2022

Background
Mobile health (mHealth) tools have emerged as a promising health care technology that may contribute to cost savings, better access to care, and enhanced clinical outcomes; however, it is important to ensure their acceptance and adoption to harness this potential. Patient adoption has been recognized as a key challenge that requires further exploration.

Objective
The aim of this review was to systematically investigate the literature to understand the factors affecting patients’ adoption of mHealth tools by considering sociotechnical factors (from technical, social, and health perspectives).

Methods
A structured search was completed following the participants, intervention, comparators, and outcomes framework. We searched the MEDLINE, PubMed, Cochrane Library, and SAGE databases for studies published between January 2011 and July 2021 in the English language, yielding 5873 results, of which 147 studies met the inclusion criteria. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and the Cochrane Handbook were followed to ensure a systematic process. Extracted data were analyzed using NVivo (QSR International), with thematic analysis and narrative synthesis of emergent themes.

Results
The technical factors affecting patients’ adoption of mHealth tools were categorized into six key themes, which in turn were divided into 20 subthemes: usefulness, ease of use, data-related, monetary factors, technical issues, and user experience. Health-related factors were categorized into six key themes: the disease or health condition, the care team’s role, health consciousness and literacy, health behavior, relation to other therapies, integration into patient journey, and the patients’ insurance status. Social and personal factors were divided into three key clusters: demographic factors, personal characteristics, and social and cultural aspects; these were divided into 19 subthemes, highlighting the importance of considering these factors when addressing potential barriers to mHealth adoption and how to overcome them.

Conclusions
This review builds on the growing body of research that investigates patients’ adoption of mHealth services and highlights the complexity of the factors affecting adoption, including personal, social, technical, organizational, and health care aspects. We recommend a more patient-centered approach by ensuring the tools’ fit into the overall patient journey and treatment plan, emphasizing inclusive design, and warranting comprehensive patient education and support. Moreover, empowering and mobilizing clinicians and care teams, addressing ethical data management issues, and focusing on health care policies may facilitate adoption.
Bridging the gap between oncology clinical trials and real-world data: evidence on replicability of efficacy results using German claims data
Authors: Ghiani Marco , Maywald Ulf , Wilke Thomas , Heeg Bart 
Published: March 2022

Aims:
Using German claims, the authors replicated the CHAARTED trial in metastatic hormone-sensitive prostate cancer.
Methods:
The authors identified metastatic hormone-sensitive prostate cancer patients replicating the inclusion/exclusion criteria of CHAARTED. Patients treated with docetaxel in combination with androgen deprivation therapy (ADT) at first line (docetaxel group) were compared with patients treated with ADT monotherapy (ADT mono group). After propensity score matching, overall survival was compared between the matched cohorts.
Results:
The authors included 441 patients. After propensity score matching, two equally sized matched cohorts of 74 patients each were compared in terms of overall survival. The hazard ratio (HR) was 0.71 (95% CI: 0.42–1.19), comparable to the HR in CHAARTED (HR: 0.72; 95% CI: 0.59–0.89).
Conclusions:
Using early comparative evidence from real-world data for regulatory and health technology assessment decisions is useful.
KESANTUNAN BERBAHASA JOKO WIDODO DALAM TALK SHOW MATA NAJWA
Authors: Putra Ida Bagus Gede Dharma , Wijana I Dewa Putu 
Published: March 2022

ABSTRAKTujuan penelitian ini adalah untuk mengetahui bentuk pematuhan dan pelanggaran maksim kesantunan berbahasa Joko Widodo dalam memberi tanggapannya terkait pandemi Covid-19 sehingga melalui penelitian ini dapat terlihat bagaimana perilaku kebahasaan Joko Widodo dalam menjalin komunikasi. Sumber data diperoleh dari media sosial Youtube. Penelitian ini menggunakan pendekatan prinsip kesopanan dari Leech. Data dikumpulkan dengan mentranskrip video Talk Show Mata Najwa episode Jokowi diuji pandemi yang diunggah di laman media sosial Youtube Najwa Shihab, peneliti kemudian menyimak dan mengklasifikasi data berdasarkan pematuhan prinsip kesantunan dan bentuk-bentuk pelanggaran prinsip kesantunan. Hasil penelitian menunjukkan bahwa Joko Widodo dalam menjalin komunikasi di program Talk Show Mata Najwa lebih dominan mematuhi prinsip kesantunan berbahasa. Sebanyak 70% tuturan Jokowi mengandung pematuhan prinsip kesantunan dan 30% tuturan Jokowi mengandung pelanggaran prinsip kesantunan. Dengan demikian, perilaku berbahasa Joko Widodo saat diundang di program Talk Show Mata Najwa telah menunjukkan perilaku berbahasa yang santun. Mengingat Joko Widodo yang bertindak sebagai kepala negara, secara implisit telah memberikan contoh kepada masyarakat dalam hal berperilaku santun saat menjalin sebuah komunikasi.Kata kunci: kesantunan berbahasa, Joko Widodo, Talk Show Mata Najwa ABSTRACT The purpose of the study is to find out the politeness and violations of politeness maxims in Joko Widodo's language in responding to the COVID-19 pandemic so that through this research it can be seen how Joko Widodo's language is in establishing communication. The data source is obtained from the social media Youtube. This research used Leech's politeness principle approach. Data was collected by transcribing the video Talk Show Mata Najwa episode Jokowi tested for pandemic which was uploaded on social media page Youtube Najwa Shihab's, the researcher then listened and classified the data based on compliance with politeness principles and forms of violation of politeness principles. that the results show that Joko Widodo in establishing communication in the Mata Najwa Talk Show program is more dominant in obeying the principles of language politeness. It is known that 70% of Jokowi's speeches contain compliance with politeness principles and 30% of Jokowi's speeches contain violations of politeness principles. Thus, Joko Widodo's language behavior when invited to the Mata Najwa Talk Show program has shown polite language behavior. Considering that Joko Widodo, who acts as head of state, has implicitly set an example for the community in terms of behaving politely when establishing communication.