bluuebunny/crossref_metadata_2025_split huggingface dataset:
High frequency ultrasound examination of inflammatory skin lesions
Authors: Jovanovic Dragan L , Ljubenovic Milanka , Jovanovic Maja R Slavkovic , Stevanovic Goran , Petrovic Aleksandar , Pesic Pavle 
Published: March 2022

Abstract
Although the use of high-frequency (higher than 20MHz) ultrasound dates back to the 1980s, its use has not yet become routine in everyday dermatological practice. High-frequency ultrasound is now used as an additional diagnostic method, primarily in the examination of cutaneous tumors. Only a few examinations dealt with the possibilities of high-frequency ultrasound in the examination of inflammatory skin changes We wanted to analyze the echographic manifestations of inflammation in different inflammatory dermatoses. The analyzed skin lesions were biopsied and the clinical diagnosis was confirmed pathohistologically, and the pathohistological characteristics were corelated with echographic manifestations. Regarding inflammation, cellularity of lesions (presence and amount of inflammatory infiltrate), oedema, dilated lumen of blood vessels was the most significant pathohistological changes that reflect on echosonografic manifestation of inflammatory skin lesions. In addition to collagen (its amount and distribution), the echogenicity of inflammatory skin changes is significantly affected by the cellularity of changes, and both hypercellularity (primarily inflammatory infiltrate) and hypocellularity (changes in the type of blisters). Monitoring of these data can potentially be used in monitoring the evolution of the disease, but also in monitoring the effectiveness of applied therapy in certain dermatoses.
Gross motor development and malnutrition in Ecuadorian children: A cross-sectional study
Authors: Cavagnari Brian , Guerrero-Vaca Darío Javier , Carpio-Arias Tannia Valeria , Duran Samuel , Vinueza-Veloz Andrés Fernando , Robalino-Valdivieso María Paulina , Morejón-Terán Yadira Alejandra , Vinueza-Veloz María Fernanda 
Published: March 2022

Abstract
ObjectiveThe objective of the present work was to study the relationship between malnutrition and gross motor development. Methodology: Sample included 6087 infants under 24 months of age, participants of the ENSANUT-ECU study. To evaluate nutritional status we calculated z-scores by sex for body mass index/age (BAZ) and height/age (HAZ). Six gross motor milestones were evaluated: sitting without support, crawling, standing and walking with support, standing and walking without support. Data was analysed using logistic regression models in R.ResultsIndependently form age, sex and other socio-economic factors, the achievement of three gross motor milestones was significantly associated to nutritional status: sitting without support, crawling and walking without support. Compared to infants with normal HAZ, the odds of sitting without support was significantly lower among infants at risk of chronic undernutrition (OR, 0.688; 95%CI, 0.496–0.954) or with chronic undernutrtion (OR, 0.601; 95%CI, 0.433–0.833). The odds of crawling (OR, 0.730; 95%CI, 0.635–0.860) and walking alone (OR, 0.741; 95%CI, 0.590–0.933) were also significantly lower among infants with chronic undernutrition in comparison to infants with normal HAZ. In general obesity/overweight were not associated with the achievement of gross motor milestones, except for sitting without support. Obese infants showed higher a odds of sitting without assistance in comparison with children with normal BAZ (OR, 1.650; 95%CI, 1.160–2.245).ConclusionsChronic undernutrition is related to delayed gross motor development. In Ecuador, public health measures are needed to be implemented in order to prevent malnutrition and its detrimental effects on infant development.
Food Insecurity During COVID-19 in Children with End-Stage Kidney Disease: A Pilot Study
Authors: Chan Melvin , Mokiao Reya , Wilson Amy C. , Pottanat Neha , Hingorani Sangeeta , Starr Michelle 
Published: March 2022

Abstract
Background
Food insecurity, an important social determinant of health among children, has become more common during the COVID-19 pandemic. Children with chronic diseases including end-stage kidney disease (ESKD) are at higher risk of food insecurity due to their complex care needs, medication burden, and dietary restrictions. No data exists describing food insecurity prevalence in pediatric ESKD patients during the COVID-19 pandemic.
Methods
Food insecurity was assessed among families of children (age 0-18 years) with ESKD on chronic dialysis at two pediatric academic medical centers. Families were screened in April 2020 using the Hunger Vital Sign, a validated 2-question screening tool. We assessed impact of COVID-19 on food insecurity. We compared serum phosphorus “pre-COVID” (January/February 2020) to “during COVID” (April/May 2020).
Results
A total of 29 families enrolled in this study. 62% (18/29) of children with ESKD lived in food insecure households, and of those, 72% (13/18) reported that COVID-19 had worsened their food insecurity status. During the COVID-19 pandemic, food insecure patients experienced greater rise in their serum phosphorus levels (p=0.03) and decreased likelihood of having adequate phosphorus control (p=0.03).
Conclusion
Food insecurity was common among children with ESKD on chronic dialysis during the COVID-19 pandemic. Children with food insecurity had a greater increase in their phosphorus levels during the pandemic than did food secure children. Further exploration into how food resources such as an onsite food pantry impacts food insecurity and phosphorus control in children with ESKD is essential.
To Study Clinicopathological and Immunohistochemical Expression of Estrogen Receptor, Progesterone Receptor and Her-2/Neu in Prostate Carcinoma
Authors: Kaur Manpreet , Khanna Menka , Kaur Harjot , Gupta Rajeev 
Published: March 2022

Background: Prostate carcinoma is leading cause of cancer related deaths amongst men. This study evaluated expression of ER, PR, HER-2/neu in Prostatic carcinoma and its correlation with Gleason score and other clinical parameters.
Methods: 50 histopathologically proven PCa cases were subjected to IHC for ER, PR, HER-2/neu.
Result: Most common age group involved was 61-80years. Retention of urine was most frequent complaint. Most prominent Gleason score was (3+4) and group grade was 2. ER expression in tumor epithelial cells was 24% and in stromal cells was 36%. PR expression in stromal cells was 32%. HER-2/neu Cytoplasmic positivity was seen in 6% cases. It was seen that with increase in Gleason grade, ER, PR, HER-2/neu positivity was decreased.
Conclusion: ER, PR, HER-2/neu can be used as biomarkers in PCa management.
Morphology of WBCs on Peripheral Blood Smear of COVID 19 Positive Patients
Authors: Khandelwal Dr Archana , Shrivastava Rashmi , Pawar Shubhangi , Pandey Avantika 
Published: March 2022

Background: Covid-19 pandemic has affected almost all the inhabited areas on our planet. Researchers are working hard to bring this disease to its resolution. There is emerging evidence everyday to point towards the altered parameters in our body. Complete blood picture and peripheral blood smears are also showing considerable changes. These changes can help to raise suspicion of Covid-19 infection at the earliest. This can help us in future to differentiate from diseases with similar findings on peripheral blood smear.
Methods: This is a prospective observational study in which 500 peripheral smears of Covid-19 infected patients were observed and the findings were recorded. All the morphological changes in WBCs, total WBC count and neutrophilic lymphocyte ratio were recorded over a span of six months from June2020-December 2020. This data was analyzed statistically.
Result: Our study reveals that there is not much change in WBC counts in initial stage of the disease. Increased Neutrophil Lymphocyte ratio is seen in almost all the patients as the disease progresses. Presence of toxic granules in the cytoplasm of cells of neutrophilic series was the earliest noticeable change in the morphology of WBCs. Earliest response is seen in lymphocytes as azurophilic granules in cytoplasm and large indented nuclei.
Conclusion: With the above study, we can conclude that there are significant and specific changes observed in the morphology of WBCs of the affected patients. This simple and easily available test can be an effective tool in helping to raise suspicion of the infection. This in turn will lead to early diagnosis and treatment.
Gravity currents with large salinity in a gravel bed valley: an experimental study
Authors: Keramaris E. , Vasileiou C. , Sagiannis K. 
Published: March 2022

Abstract
In the current study experiments in a valley (a composite cross-sectional tank consisting of a rectangular upper cross section and a lower trapezoidal) were performed. The purpose of this research is to study the gravel bed in gravity currents with large salinity. The tank is separated in two parts by a vertical gate, which separates the fresh water with the gravel bed from the salt water with the impermeable bed. When the gate opens, a flow is created due to density difference. The salinity densities are large (from 1,050 to 1,090 kg/m3). These specific densities have been chosen to simulate liquid wastes that affect the environment. Compared to experiments in the same tank without a gravel bed, it is observed that the gravel bed reduces the propagation of currents and mainly reduces the current with the smallest density difference at the lowest height. The main conclusion of this study is that the kind of channel bed plays a key role in the propagation of gravity currents. The gravel bed affects significantly the velocity and the distance traveled by the currents in comparison with impermeable bed.
Festas Religiosas no Espaço Virtual
Authors: ALVES MARIA LUCIA , ALVES MARIA LUCIA , Azevedo Lima de Barros Aline Gisele , Melo Santos Adriana , Melo Santos Adriana , Marques da Silvia Sylvana Kelly 
Published: March 2022

O artigo resulta da análise de duas festas religiosas no estado do Rio Grande do Norte: Santa Rita de Cássia e Protomártires do Brasil que, já estruturadas em suas dinâmicas, re-organizaram seus espaços, deslocando as celebrações para os meios digitais - devido ao isolamento social provocado pela pandemia do Coronavírus (SARS-CoV-2). O objetivo é analisar as festividades no espaço virtual ligadas à cultura religiosa transmitida de geração em geração. Trata-se de um estudo de caso múltiplo com abordagem qualitativa resultante da observação, questionários via comunicador instantâneo (messenger), participação em live, eventos online e discussões no meio virtual. Questiona-se, quais alterações as festas religiosas do catolicismo popular sofrem ao se deslocar para o ambiente virtual?
Probing the Interaction of Selonsertib with Human Serum Albumin: In
silico and In vitro Approaches
Authors: Baig Mohammad Hassan , Gupta Preeti , Khan Mohd. Imran , Alajmi Mohamed F. , Hussain Afzal , Hassan Md. Imtaiyaz , Dong Jae-June 
Published: March 2022

Introduction:
Selonsertib, the most recently developed selective inhibitor of apoptosis signal-regulating kinase 1. We elucidated the binding characteristics, mechanism of interaction, and dynamic behaviors of selonsertib with human serum albumin (HSA), a major circulatory transport protein.

Method:
Different biophysical approaches (fluorescence quenching and isothermal titration calo-rimetry (ITC) were combined with various in silico techniques to examine the binding of selonsertib to HSA. Molecular docking results, analysis of molecular dynamics trajectories, and essential dy-namics investigations indicated the stable binding of selonsertib to HSA. Further in vitro studies were performed to validate the observed interaction.

Result:
ITC results confirmed the robust binding and high affinity of selonsertib and HSA. Like-wise, the fluorescence quenching results highlighted the binding affinity of selonsertib and HSA. Collectively, our findings offer deeper insight into the binding mechanism of selonsertib and HSA, emphasizing the selonsertib-mediated structural changes within HSA, along with a comprehensive rationale for the biological transport and accumulation of selonsertib in the blood plasma.

Conclusion:
Therefore, considering the bioavailability and effectiveness of selonsertib, assessing the interactions of this inhibitor with carrier proteins is crucial to elucidate its biological processes at the molecular level. This evidence carries the considerable scientific potential for future drug de-sign.
Recent Developments of Nanomaterials and Sensor Performance for
Electronic Skin
Authors: Xu Ke , Su Rong 
Published: March 2022

Abstract:
Throughout the research of flexible nanomaterials and sensing technology in recent years,
electronic skin has been widely developed as well as applied in many fields. As a bionic flexible
tactile sensor, electronic skin can simulate the touching of human skin with external signals as well
as collect and detect dynamic information of the physical surface. This paper reviews the flexible
substrate materials and electrode nanomaterials of electronic skin. The stable support of the flexible
substrate largely determines the mechanical properties of the electronic skin. At the outset, this article
introduces the flexible substrate materials commonly used in electronic skins. PDMS, PI, and
PET are typical representatives of flexible substrate materials. Then, the nanomaterials used for electrodes
are discussed, including one-dimensional and two-dimensional nanomaterials, especially emphasizing
the innovation of the sensor performance about the advanced electronic skin along with the
use of different nanomaterials under the integrated application background. In addition, these electrode
nanomaterials need to be appropriately embedded in flexible substrate materials. The response
time, sensitivity, detection limit, response range, and the cycle of electronic skin are selected for
comparison. Finally, the opportunities and challenges of electronic skin in nanomaterials and sensing
technology are summarized.
Black Fungus: An Alarming Infection During Novel Coronavirus: A Review
Authors: Das Raneet , Roy Jayita , Ashique Sumel 
Published: March 2022

Abstract:
Mucormycosis is the most emerging angioinvasive fungal infection of filamentous fungi of the
Zygomycetes class, which, when neglected, causes severe disseminated infection along with significant
chances of morbidity and mortality. The diagnosis and treatment remain challenging for the doctors. It
has been observed that people who have been suffering from different diseases, such as hematological
malignancies and uncontrolled diabetes, or who have gone through different surgeries, such as hematopoietic
stem cell transplant, and solid transplantation, are the most affected ones. On the other hand, people
who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) typically
show the symptoms of mucormycosis after 1-2 weeks of successful recovery. Standard treatment of mucormycosis
is traditionally considered an amphotericin B intravenous (IV) drug as initial therapy, although
posaconazole and isavuconazole are also used. The core objective of the review is to typically
focus on the area of the sudden cause of mucormycosis in the patients who have already recovered from
SARS-CoV-2.
MULHERES NO FIO DA NAVALHA: FEMINICÍDIO, BARBÁRIE E PEDAGOGIA DA CRUELDADE
Authors: De Sá Pereira da Silva Rosária de Fatima 
Published: March 2022

Este artigo pretende elucidar o feminicídio enquanto um fenômeno estrutural e atinente ao movimento histórico do capital, no qual para sua compreensão, incorporaremos a análise, a partir dos seguintes eixos: 1) Apresentação do debate conceitual sobre as relações de gênero e violência; 2) Exame do processo de constituição do patriarcado moderno e problematização e reconhecimento do feminicídio enquanto um fenômeno sustentado pelo capitalismo e pelo patriarcado; 3) Análise dos dados sobre mortalidade violenta de mulheres no Brasil.
Persepsi dan Sikap Calon Guru Biologi Terhadap Potensi Instagram Sebagai Sarana Edutainment dalam Pembelajaran Biologi
Authors: Utami Aprillyana Dwi , Kurniasiih Mike Dewi 
Published: March 2022

The purpose of this study was to examine prospective biology teachers’ perceptions and attitudes towards Instagram as a potential edutainment tool in biology learning. The study involved 87 prospective biology teachers from 4 public universities in Indonesia. Participants answered 15 closed questions and three open questions. Then data were analysed quantitatively and qualitatively. The results demonstrated that prospective biology teachers had highly positive perceptions of Instagram as an edutainment tool in biology learning. Respondents strongly agree that Instagram is easier to use than other learning platforms to create and upload learning content. Prospective biology teachers’ attitudes show that they agree to use Instagram as an edutainment tool in biology learning. The use of Instagram also has the potential to increase motivation, interaction, and creativity and is enjoyable in learning biology.
Key words: Instagram, edutainment, perceptions, prospective biology teacher

Abstrak. Tujuan dari penelitian ini adalah untuk menguji persepsi dan sikap calon guru biologi terhadap Instagram sebagai sarana edutainment yang potensial dalam pembelajaran biologi. Penelitian ini melibatkan 87 calon guru biologi dari 4 perguruan tinggi negeri di Indonesia. Partisipan menjawab 15 pertanyaan tertutup dan tiga pertanyaan terbuka. Kemudian data dianalisis secara kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa calon guru biologi memiliki persepsi yang sangat positif terhadap Instagram sebagai sarana edutainment dalam pembelajaran biologi. Responden sangat setuju bahwa Instagram lebih mudah digunakan dibandingkan platform pembelajaran lain untuk membuat dan mengunggah konten pembelajaran. Sikap calon guru biologi menunjukkan bahwa mereka setuju untuk menggunakan Instagram sebagai sarana edutainment dalam pembelajaran biologi. Penggunaan Instagram juga berpotensi untuk meningkatkan motivasi, interaksi, dan kreativitas serta menyenangkan dalam pembelajaran biologi.
Kata kunci: Instagram, edutainment, persepsi, calon guru biologi,
Caracterización clínico-epidemiológica del tromboembolismo pulmonar en autopsias del Instituto de Medicina Legal de Medellín 2010-2020
Authors: Pareja Pineda Jorge Iván , Londoño Betancur Sara Vanessa , Cardona Arias Jaiberth Antonio 
Published: March 2022

Introducción: A pesar de disponer de métodos diagnósticos y terapéuticos eficaces, el tromboembolismo pulmonar (TEP) es una afección que a lo largo de décadas ha causado una elevada morbilidad y mortalidad.
Objetivo: Describir las características clínico-epidemiológicas y anatomo-patológicas de los diagnósticos de TEP en cadáveres que ingresaron por muerte súbita al Instituto Nacional de Medicina Legal y Ciencias Forenses de Medellín 2010-2020.
Métodos: Estudio descriptivo de una cohorte retrospectiva, formada por los casos que ingresaron al Instituto de Medicina Legal por muerte súbita con causa de muerte por establecer, diagnosticados con TEP. Los análisis se realizaron con frecuencias y medidas de resumen en SPSS 27.0.
Resultados: Entre 46097 necropsias médico legales realizadas en el período estudiado, 164 casos (0,36 %) corresponden a TEP. La edad media fue 57,0±19,3 años y 51,2% mujeres. El 57,9% fue muerte natural, en 37,2% se presentó trauma y 36,0% otro evento circulatorio. En la mayoría de los casos, el deceso ocurrió en la vivienda (47,0%) y la vía pública (25,6%). En la trombosis, 45,1% fue de la arteria pulmonar (trombo cabalgado); 34,8% de arterias pulmonares intraparenquimatosas y 52,4% de los fallecidos presentaron trombosis venosa profunda de miembros inferiores.
Conclusión: El TEP es una importante causa de muerte en pacientes intra y extrahospitalarios, a pesar de los métodos diagnósticos, farmacológicos y no farmacológicos existentes para su prevención. La realización de un mayor número de autopsias clínicas permitirá revelar el verdadero impacto en nuestro medio de esta complicación y mejorar la calidad en el cuidado de los pacientes.
Effects Real Earnings Management and Liquidity Leverage Relation Analysis Case study: accepted plants into Tehran stock exchange
Authors: Aryannejad Abbas 
Published: March 2022

The main purpose of the present research is to investigate the relationship between liquidity leverage and real earnings management of the accepted plants into Tehran stock exchange in 2014. Through determination the concept of creation steps or liquidity leverage expansion as well as real earnings management, this paper is going to describe how this kind of thought is created in accepted plants. Methodology: Having explained its effective factors, they are analyzed and classified and finally combining various presented models and theories, they are analyzed by specialists. In this research 91 plants out of accepted ones in Tehran stock exchange which have got particular properties are analyzed and used to investigate the relationship between liquidity leverage and real earnings management. Results: Finally, considering concluded meaningful relations of studied secondary hypotheses, the first hypothesis which there is a meaningful relation between liquidity leverage and real earnings management is absolutely verified. Having studied hypotheses using T-test, they can be classified based on their averages. This classification demonstrates that cash conversion cycle index has got the most related to the real earnings management. Conclusion: Research conclusions demonstrate that there is a meaningful relation between liquidity leverage and real earnings management. Considering the conclusions, some suggestions are presented, too.
PELATIHAN SELF MANAGEMENT BAGI PERAWAT SEBAGAI UPAYA PENINGKATAN KUALITAS HIDUP PENYANDANG THALASSEMIA DI TASIKMALAYA
Authors: Mariani Dini , Badriah Siti 
Published: March 2022

Thalassemia adalah suatu kelompok kelainan genetika dari sintesis rantai globin alpha atau beta secara total atau parsial. Tanda dan gejala bervariasi tergantung dari jumlah dan tipe rantai globin yang dipengaruhi. Jumlah penyandang thalassemia dari tahun ke-tahun meningkat terus termasuk jumlah penyandang thalassemia di Tasikmalaya dan memerlukan perawatan secara komprehensif untuk meningkatkan kualitas hidup penyandang thalassemia. Sasaran dari kegiatan pengabdian masyarakat ini adalah perawat yang memberikan perawatan pada penyandang thalassemia di Tasikmalaya. Metode pelatihan yang digunakan menggunakan ceramah, tanya jawab, simulasi dan role play. Jumlah peserta pelatihan sebanyak 35 orang., peserta merupakan perawat yang memberikan asuhan keperawatan kepada penyandang thalassemia. Hasil menunjukkan terjadinya peningkatan pengetahuan pada perawat setelah diberikan pelatihan. Pelatihan self management bagi perawat menjadi salah satu pilihan intervensi dalam upaya peningkatan kualitas hidup penyandang thalassemia. Disarankan agar pelatihan self management bagi perawat bisa diselenggarakan dalam skala besar sehingga semua unit thalassemia dapat menerapkan dukungan self management bagi para penyandang thalassemia.