bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of mast cells in the pathogenesis of chronic obstructive pulmonary disease
Authors: Budnevsky A. V. , Avdeev S. N. , Ovsyannikov E. S. , Savushkina I. A. , Shkatova Ya. S. , Shishkina V. V. 
Published: November 2022

Chronic obstructive pulmonary disease (COPD) is one of major causes of chronic noncommunicable diseases and mortality worldwide. The roles of macrophages, T-lymphocytes, neutrophils, and other cells in the development of chronic inflammation in this disease are well studied, but more and more researchers have focused on mast cells (MC) in recent years.The aim of this work is to summarize the data of experimental and clinical studies on the possible role of MCs in the pathogenesis of COPD. To this end, the review analyzed data on the relationship between MCs and respiratory function parameters in COPD, as well as the distribution of MCs subpopulations in different parts of the respiratory tract. The involvement of proteases (chymase and tryptase) in the development of inflammatory and fibrotic changes in COPD is discussed. The review presents research findings that indicate the possible involvement of chymase in pulmonary artery remodeling, increased secretion of mucins, and slowing down the airway epithelial repair. The role of MC tryptase in the development of fibrotic changes in the lungs and airways in COPD is also highlighted. A separate section of the review is devoted to chemokines that promote MC migration and their specific receptor. Chemokines play a special role in the development of inflammation in COPD.Conclusion. The available data suggest that MCs play a major role in the pathogenesis of COPD. Because of the inconsistency of some results, further clinical studies in larger cohorts of patients are needed.
Arystokrata i lektury epoki przełomu, czyli o Janie Feliksie Amorze Tarnowskim jako czytelniku
Authors: Deszczyńska Martyna 
Published: November 2022

Artykuł podejmuje problematykę historii czytelnictwa w epoce przełomu XVIII i XIX wieku, czyli między polskim oświeceniem a epoką romantyzmu, na przykładzie arystokratycznego czytelnika i właściciela bogatego księgozbioru – Jana Feliksa Amora Tarnowskiego (zm. 1842). Rodzinne relacje Tarnowskiego, podróże i wpływy jego nauczycieli, a także studia w bibliotekach ukształtowały jego osobowość intelektualną i dały mu głęboką erudycję. Był działaczem ruchu kulturalnego, członkiem towarzystw naukowych i masonerii, senatorem. Zastosowana w tekście metodologia opiera się na naukach historycznych jako najbardziej odpowiednich w tego rodzaju problemach. Teza dotycząca lektury Tarnowskiego została potwierdzona na podstawie jego rękopisów, notatek i niepublikowanych fragmentów z archiwum rodzinnego (przechowywanego w Archiwum Narodowym w Krakowie) oraz monografii drukowanej (1819), w której ślady cytatów i tytuły książek zostały uznane za pewne dowody ich czytania. Jego zainteresowania koncentrowały się na średniowiecznej i wczesnonowożytnej historii, religii i literaturze, pozostawały pod wpływem historyzmu oświeceniowego, historii kultury i językoznawstwa, ale także religijnego odrodzenia katolickiego, mistycyzmu i religijności czasów Restauracji. Tarnowski jako czytelnik wybierał klasyczną literaturę europejską i światową, pośród której chciał umieścić książki autorów polskich.
The Pragmatics of AIN’T within Academic and Social Context
Authors: Jumanto Jumanto , Asmarani Rahmanti , Syamsu Rizal Sarif , Sulistyorini Haryati 
Published: November 2022

This paper has explored the form, the meaning, and the function of the contraction AIN’T, with the corpus data retrieved from English-affiliated URLs or Websites (web-data), through interpretive techniques and a coding analysis. The utterance AIN’T belongs to non-standard or informal English, which represents or is derived from the forms AM NOT, IS NOT, ARE NOT, HAS NOT, HAVE NOT, DO NOT, DOES NOT, DID NOT, and the others. The meaning of AIN’T implies different aspects, i.e. informality, topic area, low social class, emphasis, and content. The utterance AIN’T is part of close language, or is used for close people for friendship or camaraderie. AIN’T belongs to informal utterances, as it is incomplete, shorter, cut-down (or contracted) from other forms. The utterance AIN’T should be taught academically in classrooms or other teaching and learning encounters as informal language with its various derived constructions, and students or learners should be made aware that AIN’T is part of close language which is used to close people for friendship or camaraderie within interpersonal or social context. Use of AIN’T to not close people or superiors or others in a formal situation may lead to a rude situation, and a probable disharmony entails. Keywords: pragmatics; politeness; camaraderie; informal English; AIN’T.
Profil Efikasi Diri Mahasiswa dalam Mata Kuliah Micro Teaching (Studi pada Mahasiswa SI PGSD STKIP Muhammadiyah Blora)
Authors: Palupi Bening Sri 
Published: November 2022

Mata kuliah <em>micro teaching</em> di persiapkan untuk mahasiswa S1 PGSD sebagai bekal keterampilan mengajar saat mereka sudah menjadi guru <em>in-service</em>. Tugas mata kuliah ini melibatkan banyak unsur yang kompleks mulai dari kemantapan teori dan strategi mengajar, penyusunan skenario pembelajaran sampai pada praktik mengajar. Praktik mengajar inilah yang sangat ditentukan dari dalam diri mahasiswa yang bersangkutan, utamanya efikasi diri. Artikel ini bertujuan untuk mengambarkan profil efikasi diri mahasiswa dalam perkuliahan <em>micro teaching</em>. Pengumpulan data dilakukan pada 30 mahasiswa PGSD dengan isntrumen angket, observasi, dan wawancara. Uji keabsahan data dilakukan dengan triangulasi teknik, sumber, dan metode. Analisis interaktif Milles &amp; Huberman digunakan sebagai teknik analisis data. Hasil penelitian menunjukkan bahwa: (1) mahasiswa lebih percaya diri pada praktik ketiga; (2) sebagian besar mahasiswa termotivasi oleh media teman sekelasnya; dan (3) dukungan teman sekelas mempengaruhi efikasi diri mahasiswa dalam praktik mengajar. Jadi, efikasi diri mahasiswa memiliki peran yang substansial terhadap mata kuliah <em>micro teaching</em>. Oleh karenanya, dosen pengampu mata kuliah juga perlu memperhatikan faktor pendukung dan penghambat perfoma mengajar mahasiswa, utamanya terkait pengkondisian situasi belajar pada perkuliahan.
Pengembangan Buku Ajar Statistika Dasar Untuk Penelitian Pendidikan Fisika
Authors: Reski Andi 
Published: November 2022

<p>Penelitian ini bertujuan untuk mengembangankan buku ajar pada matakuliah Statistika Dasar yang layak dijadikan sebagai sumber belajar oleh mahasiswa pendidikan Fisika dalam perkuliahan dan penyusunan tugas akhir. Research and Development (R&amp;D) dipilih sebagai metode penelitian ini dan menggunakan model pengembangan ADDIE sampai pada tahap <em>development</em>. Pada penelitian ini, produk yang dikembangkan divalidasi dan diuji keterbacaan untuk menilai kelayakan. Sebanyak 20 orang mahasiswa pendidikan fisika dipilih menjadi sampel uji keterbacaan yang dipilih melalui teknik <em>purposive sampling</em>. Instrumen pengumpulan data menggunakan lembar angket validasi dan lembar angket uji keterbacaan produk. Adapun nilai rata-rata dari validator ahli materi dan ahli media adalah 93,1 dan hasil pengujian keterbacaan oleh mahasiswa pendidikan fisika diperoleh nilai sebesar 92,4. Berdasarkan data-data kuantitatif yang diperoleh dan diinterpretasikan ke dalam data kualitatif maka buku ajar Statistika Dasar untuk penelitian pendidikan Fisika masuk dalam ketegori layak untuk digunakan sebagai sumber belajar. Namun, dalam penelitian masih terdapat keterbatasan karena hanya dilaksanakan sampai tahap <em>development </em>sehingga perlu adanya penelitian lanjutan untuk menilai keefektifan buku ajar Statistika Dasar ini dengan cara melanjutkan ke tahap keempat yakni <em>implementation </em>dan tahap kelima yakni evaluation.</p>
Dados Abertos Governamentais e Mobilidade Urbana: Análise Comparada de Buenos Aires e Rio de Janeiro
Authors: Garcia Giulia , Vaz José Carlos , Matheus Ricardo , Martin Jayo 
Published: November 2022

Objetivo da pesquisa: Caracterizar e interpretar as estratégias para uso e disponibilização de dados abertos de mobilidade urbana em duas metrópoles latino-americanas, Buenos Aires e Rio de Janeiro, entendidas como casos relevantes para o estudo da abertura de dados de mobilidade urbana no contexto regional, por conta de suas características e trajetórias de gestão, uso e abertura de dados.
Enquadramento teórico: Incorporou os principais modelos analíticos e explicativos sobre as estratégias e instrumentos de abertura de dados governamentais, com destaque para o modelo de Cinco Estrelas de Berners-Lee e os 15 Princípios de Dados Abertos do Opengovdata.
Metodologia: Baseou-se em um estudo de caso coletivo aplicado a dois casos, conforme Robert Stake (1995), sem prejuízo de sua expansão futura a mais casos.
Resultados: Tanto individualmente – para cada governo local – quanto nas comparações realizadas, foi possível compreender as estratégias utilizadas, bem como sua relação com o contexto e os limites e potenciais da abertura de dados nesse campo. Os casos guardam diferenças entre si, em suas políticas de governo aberto e mecanismos de dados abertos, mas também compartilham elementos comuns, como os tipos de dados de mobilidade urbana disponibilizados e a natureza de algumas estratégias e iniciativas de dados abertos adotadas.
Originalidade: Além da originalidade do modelo teórico, que pode embasar o estudo de outros casos, as análises produzidas aportam uma contribuição original para o estudo da abertura de dados em mobilidade urbana em duas significativas metrópoles latino-americanas.
Contribuições teóricas e práticas: O estudo abre caminho para a aplicação do modelo em outras cidades e para o aprofundamento do conhecimento sobre abertura de dados governamentais de mobilidade urbana.
Destinação de Bens Públicos: o Dilema do Desfazimento dos Bens da Extinta Rede Ferroviária Federal S.A.
Authors: Leal Guimarães Duanne Emanuel , Da Silva de Oliveira Raimunda Macilena , Ferreira Dias Gessé , Sausen Soares Cristiano 
Published: November 2022

Contexto do caso: Este caso de ensino apresenta uma situação vivenciada no setor público, apontando a complexidade de se resolver questões referentes à gestão dos bens públicos, especialmente quanto ao seu desfazimento.
Dilema do caso: No caso particular, os bens móveis não operacionais da extinta Rede Ferroviária Federal S.A. (RFFSA) foram destinados ao Departamento Nacional de Infraestrutura de Transportes (DNIT), contudo, a autarquia tem a intenção de realizar o desfazimento desses bens, haja vista serem inservíveis para o desempenho de suas atividades. O discente foi convidado a ocupar a posição da comissão de desfazimento, bem como dos gestores, indicando as possíveis ações para o reconhecimento, mensuração, evidenciação e destinação dos bens provenientes da RFFSA.
Fechamento do caso: No desfecho do caso, recomenda-se que o docente expositor comente, em linhas gerais, sobre como o DNIT vem procedendo em relação ao dilema, abordando tanto as questões contábeis quanto as de escolha da modalidade de desfazimento de bens.
Characteristics and Formation Mechanism of Multiscale Storage Spaces in Ancient Deep Tight Reservoirs: Examples from the Cambrian Yurtus Formation in the Northern Tarim Basin, China
Authors: Xu Qilu , Cheng Yongzhi , You Donghua , Zhang Yu , Li Xinle , Xu Jin , Chen Xudong 
Published: November 2022

AbstractUnder the background of complicated diagenetic fluids, high-temperature pressure in superimposed basin, the pore-forming and pore-preserving effects of deep tight reservoirs are complex, and the formation mechanism of high-quality reservoirs has always been the core issue. With the discovery of oil and gas in ultradeep drilling in Tarim Basin, the most unconventional tight reservoir of Lower Cambrian Yuertus Formation in Tabei area began to receive attention. Based on the research of typical field outcrops in Tabei area, the lithofacies, reservoir space differences, and reservoir formation mechanism are systematically analyzed. (1) The stratum has undergone complex multistage diagenetic fluid transformation, and the rock types are diverse with great differences; siliceous rock and dolomite are the main rock types, often in thin-medium layered distribution. (2) After long-term deep burial transformation, siliceous rock and dolomite can still retain a large number of effective storage spaces; hydrothermal dissolution pores, organic acid dissolution pores, atmospheric freshwater dissolution pores, and intercrystalline pores are the main pore types, which provide main storage spaces. Multiscale pores are developed in siliceous rock and dolomite, with good connectivity and good pore structure. (3) The large-scale storage spaces mainly come from the effective maintenance of primary pores, organic matter, and hydrothermal dissolution. The siliceous minerals and dolomite have stable properties and strong resistance to compaction and can effectively maintain the early pores. (4) The large-scale reservoir space was formed in the early diagenetic stage; the pressure-solution and cementation are the two most important diagenetic processes for reducing storage spaces; however, under the pore-forming and pore-preserving effects of early silicification and dolomitization, various types of dissolution, and oil charging, the tight lithology can still maintain effective storage spaces. The related research has important theoretical and practical significance for studying the formation mechanism of tight reservoirs in deep ancient strata and predicting high-quality reservoirs.
Propagating Hydraulic Fractures from Wellbores: Effects of In-Situ Stress and Near-Wellbore Stress Redistribution
Authors: Gao Qian , Zhou Desheng , Ghassemi Ahmad , Liu Xiong , Liu Yafei , Guo Minhao 
Published: November 2022

Summary
As a mature technology to enhance the permeability of geological formations, hydraulic fracturing has widely been used in geothermal energy development and in the petroleum industry. Due to its effectiveness in practical applications, it attracts many research efforts. Because of the complexity of hydraulic fracturing itself and the complex distribution of stresses around wellbores, accurately describing the behaviors of hydraulic fractures is still a challenging task. In this study, a numerical model is developed to simulate curved propagation of hydraulic fractures from a wellbore, and emphases are placed on influence of in-situ stress and near wellbore stress redistribution.
In the developed hydromechanical model, special considerations are given to its ability to simulate curved propagation of hydraulic fractures. The propagation of fractures is modeled through the phase-field method. Several cases on hydraulic fracture initiation and propagation from horizontal wellbores are studied through the proposed model. The model has been successfully verified through analytical solutions. The influence of stress redistribution caused by wellbore pressurization on hydraulic fracture initiation from wellbores is analyzed. Under different in-situ stress configurations and initial fracture orientations (perforation or flaws around wellbores are represented by the initial fractures), several patterns of hydraulic fracture propagation around the wellbores are recognized. It is found that the stress redistribution in the close vicinity of wellbores has great influences on the fracture initiation and propagation, and it makes hydraulic fractures propagate in nonplanar, complex manners. As hydraulic fractures propagate away from the stress redistribution regions around the wellbores, in-situ stress then determines the directions of fracture propagation; the curvature of fracture growth paths is mainly determined by the difference in in-situ stress, for example, σv − σhmin in this study. It has also been demonstrated that, when analyzing fracture propagation from wellbores, the wellbore stability or nonlinear deformation of a wellbore should be considered together with the fracture propagation conditions.
IGF2BP3 Mediates the mRNA Degradation of NF1 to Promote Triple-Negative Breast Cancer Progress via an m6A-Dependent Manner
Authors: Ding Qiang , Zhang Xu , Shi Liang , Sun Handong , Wang Zi-Wen , Xu Feng , wei Ji-Fu 
Published: November 2022

Abstract
N6-methyladenosine (m6A) is the most abundant reversible modification of eukaryotic mRNA. Emerging evidence has supported that m6A plays a vital role in tumorigenesis. As a crucial reader, IGF2BP3 usually mediates the stabilization of mRNAs in an m6A-dependent manner. However, the functions and m6A mechanism of IGF2BP3 have not been reported in triple-negative breast cancer (TNBC). Here we showed that IGF2BP3 was highly expressed in TNBC tissues and cell lines and was associated with poor prognosis. TET3-mediated IGF2BP3 promoter hypomethylation leads to upregulation of IGF2BP3 expression in TNBC. Knocking down IGF2BP3 markedly inhibited the proliferation and increased the apoptosis of TNBC in vitro and in vivo. Intersection co-assays revealed that IGF2BP3 decreased NF1 stabilization in an m6A-dependent manner. NF1 expression was negatively correlated with IGF2BP3, and knockdown of NF1 could rescue the phenotypes of IGF2BP3 knockdown cells partially in vitro and in vivo. Mechanistically, m6A reader IGF2BP3 promoted proliferation and inhibited the apoptosis of TNBC by destabilizing NF1 mRNA in an m6A-dependent manner. TET3-mediated IGF2BP3 promoter hypomethylation leads to upregulation of IGF2BP3 expression in TNBC. It suggested that IGF2BP3 has the potential to be the target for TNBC treatment.
A novel filter bank design for speech emotion recognition
Authors: PARLAK Cevahir , ALTUN Yusuf 
Published: November 2022

Abstract
In this study, a novel filter bank design is proposed for speech emotion recognition to replace current state-of-the-art MFCC (Mel Filter Cepstral Coefficients) and Mel filter banks. These novel filter banks are considered to have a great impact and pave the way for great developments and improvements over speech emotion recognition applications. Many filter banks have been proposed to model speech recognition applications but these models either contain too many banks or need some cumbersome mathematical operations to compute. MFCC requires the calculation of DCT (Discrete Cosine Transform), and it is also too difficult to interpret the MFCC coefficients. Mel filters are easy to interpret but they contain too many filters. The novel filter banks are faster and easier to compute. Moreover, they can be interpreted better compared to the MFCC and Mel filters. We apply these filter banks with NVIDIA’s CNN and ResNet deep convolutional networks. We also implement feature selection, data augmentation, and various techniques to combat problems of imbalanced datasets to show the effectiveness of proposed filter banks.
Promoting sustainable development by optimizing city-level solar photovoltaic deployment
Authors: Li Jiashuo , Guo Jinqiang , Zhang Ning , Liu Xi , Feng Kuishuang 
Published: November 2022

Abstract
Motivated by carbon neutrality, the large-scale installation of low-carbon solar photovoltaic (PV) will be accelerated in the coming decades. Large-scale PV also signficantly contributes to the sustainable development goals (SDGs), however, where and how much PV need to be installed to promote SDGs need to be thoroughly answered. Here we comprehensively assessed and compared the multiple benefits and SDGs progress under different city-level PV deployment scenarios, by incorporating a set of environmental-resource-social factors. We find different goal-oriented deployment scenarios result in enormous variations in PV distribution as well as tradeoffs/synergies between SDGs in different cities. The water-saving-oriented scenario witnesses the greatest carbon-air quality-water co-benefits, as well as the biggest improvement in SDGs. While the greatest promotion in employment-related SDG is realized at the expense of compromising the environmental-water benefits under the job creation-oriented scenario. SDGs in less developed cities gain greater improvement than that of rich cities under all scenarios. This study underscores the necessity of considering the spatial heterogeneity and the underlying trade-offs between various SDGs and regions when formulating energy transition strategies.
Age and cancer type: Associations with increased odds of receiving a Late Diagnosis in people with advanced cancer.
Authors: Mills Sarah Elizabeth Ellen , Buchanan Deans , Donnan Peter T , Smith Blair H 
Published: November 2022

Abstract

Purpose:
COVID has increased the rates of late cancer diagnoses. Clinicians need to be aware of which patients are at higher risk of receiving a late cancer diagnosis, in order to deliver appropriate and timely care planning and minimise avoidable late diagnoses. We aimed to determine which demographic and clinical factors are associated with receiving a ‘late’ cancer diagnosis (within the last 12 weeks of life).
Method:
Retrospective cohort study of 2,443 people who died from cancer (‘cancer decedents’) in 2013-2015. Demographic and cancer registry datasets linked using patient-identifying Community Health Index numbers. Analysis used binary logistic regression, with univariate and adjusted odds ratios (SPSS v25).
Results :
One third (n=831,34.0%) received a late diagnosis. Age and cancer type were significantly associated with late cancer diagnosis (p<0.001). Other demographic factors were not associated with receiving a late diagnosis. Cancer decedents with lung cancer[i]were more likely to have late diagnosis than those with bowel (95%CI 1.52 (1.12 to 2.04)), breast or ovarian (95%CI 3.33 (2.27 to 5.0) or prostate (95%CI (9.09 (4.0 to 20.0)) cancers. Cancer decedents aged >85 years had higher odds of late diagnosis (95%CI 3.45 (2.63 to 4.55)), compared to those aged <65 years.
Conclusions:
Cancer decedents who were older and those with lung cancer were significantly more likely to receive late cancer diagnoses than those who were younger or who had other cancer types.
[i] Odds Ratios presented in abstract are the inverse of those presented in the main text, where lung cancer is the reference category. Presented as 1/(OR multivariate).
Analysis of Phytochemical Composition and Antioxidant Activities of Aqueous and Methanol Extracts of Black, Green, Purple, and White Teas Grown in Kenya
Authors: Muriuki Joseph , Adan Asma , Maina Edward , Mureithi Haddison , Lagat Nancy , Baliach Caroline , Lwembe Raphael , Ndemwa Philip , Irungu Beatrice 
Published: November 2022

AbstractBackground Tea, a widely consumed beverage worldwide increasingly elicits interest due to reported high levels of polyphenols. Polyphenols have been extensively investigated, as they are a potential source of natural antioxidants. Methods The aim of the study was to determine and compare the phytochemical composition and antioxidant activities of aqueous and methanol extracts of black, green, purple, and white teas found in selected regions of Kenya.A total of 56 samples were obtained from tea classified as black, green,purple, and white tea in various factories. The samples were then grounded and extracted using methanol and de-ionized water for 48 hours. The composition of phenolic and tannin contents was determined using Folin- Ciocalteu method. Flavonoids content was determined through the formation of the flavonoids– aluminum complex assay. Antioxidant activity was determined through the DPPH scavenging activity and the iron-reducing power of the extracts. Results The phenolic contents in all samples were significantly higher than flavonoid and tannin levels. In samples extracted with water, the phenolic contents were high (41.74 ± 5.25) mg/g, while flavonoid (0.58 ± 0.06 mg/g) and tannin levels (2.47 ± 0.79) mg/g were relatively low. There was a negative correlation between phytochemicals and the antioxidant activity of the various teas. Conclusions The findings suggest that the different teas have high levels of phytochemicals and are natural antioxidants, however there is no significant variation at p = 0.05 in the composition of phytochemical compounds among the different tea groups.