bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipidome‐ and Genome‐Wide Study to Understand Sex Differences in Circulatory Lipids
Authors: Tabassum Rubina , Ruotsalainen Sanni , Ottensmann Linda , Gerl Mathias J. , Klose Christian , Tukiainen Taru , Pirinen Matti , Simons Kai , Widén Elisabeth , Ripatti Samuli 
Published: October 2022

Background
Despite well‐recognized differences in the atherosclerotic cardiovascular disease risk between men and women, sex differences in risk factors and sex‐specific mechanisms in the pathophysiology of atherosclerotic cardiovascular disease remain poorly understood. Lipid metabolism plays a central role in the development of atherosclerotic cardiovascular disease. Understanding sex differences in lipids and their genetic determinants could provide mechanistic insights into sex differences in atherosclerotic cardiovascular disease and aid in precise risk assessment. Herein, we examined sex differences in plasma lipidome and heterogeneity in genetic influences on lipidome in men and women through sex‐stratified genome‐wide association analyses.

Methods and Results

We used data consisting of 179 lipid species measured by shotgun lipidomics in 7266 individuals from the Finnish GeneRISK cohort and sought for replication using independent data from 2045 participants. Significant sex differences in the levels of 141 lipid species were observed (
P
<7.0×10
−4
). Interestingly, 121 lipid species showed significant age‐sex interactions, with opposite age‐related changes in 39 lipid species. In general, most of the cholesteryl esters, ceramides, lysophospholipids, and glycerides were higher in 45‐ to 50‐year‐old men compared with women of same age, but the sex differences narrowed down or reversed with age. We did not observe any major differences in genetic effect in the sex‐stratified genome‐wide association analyses, which suggests that common genetic variants do not have a major role in sex differences in lipidome.

Conclusions
Our study provides a comprehensive view of sex differences in circulatory lipids pointing to potential sex differences in lipid metabolism and highlights the need for sex‐ and age‐specific prevention strategies.
COVIC: Collecting Visualizations of COVID-19 to Outline a Space of Possibilities
Authors: Kahn Paul , Dubberly Hugh , Rodighiero Dario 
Published: October 2022

Abstract
We describe the COVID-19 Online Visualization Collection (COVIC), its goals, how it came to be, and why we propose such a collection as a new path for design research. The COVIC database contains a collective visualization response to the COVID-19 pandemic gathered from approximately 3,000 articles, each containing one or more visualizations (about 12,000 in total). We have sought to create a resource for design research—a boundary object—that will be useful to any of the disciplines brought together through their response to the pandemic event.
A Legal Analysis of the Protection of the Rights of Persons with Disabilities During the COVID-19 Pandemic in Nigeria
Authors: Animashaun Oyesola , Chitimira Howard 
Published: October 2022

Abstract
Persons with disabilities are often discriminated against in society on the basis and/or grounds such as race, ethnicity, cultural beliefs, as well as religious beliefs. Moreover, there is a general negative societal attitude and a negative perception against persons with disabilities globally. For instance, persons with disabilities are negatively treated as a charitable problem of the society in many countries, including Nigeria. This approach could have deliberately or inadvertently led to the omission of the specific rights of persons with disabilities from the list of fundamental rights under the Nigerian Constitution, 1999. However, the recent enactment of the Discrimination Against Persons with Disabilities (Prohibition) Act, 2018, could be a positive step in addressing numerous challenges such as poverty, unemployment, discrimination, and health care problems that are faced by persons with disabilities in Nigeria, especially in the wake of the novel coronavirus (COVID-19) pandemic. Against this background, the article discusses the challenges that are encountered by persons with disabilities in Nigeria during the COVID-19 pandemic. This is undertaken to, inter alia, assess the adequacy of the legal and constitutional protection on the rights of persons with disabilities, especially during the ongoing COVID-19 pandemic in Nigeria. Moreover, the flaws and gaps in the current legal and constitutional regime for the protection of the rights of persons with disabilities in Nigeria are discussed. Thereafter, possible recommendations to curb such flaws in Nigeria are provided.
Post-Pandemic Legislation in Indonesia
Authors: Arifin Saru 
Published: October 2022

Abstract
Since the imposition of lockdowns or restrictions on social mobility in response to pandemics in 2020, the operations of many governments have undergone a radical transformation. Indonesia’s compliance with the new health protocols did not stand out as exceptional in this regard. This article investigates how and to what extent the Indonesian Parliament utilized ict during the pandemic, as well as the future viability of ict as a legislative tool. This article argues that the Parliament’s use of ict during the pandemic improved its effectiveness, efficiency, and openness in carrying out its responsibilities. In addition, the number of mp s in attendance – albeit virtual – increased. This article suggests that appropriate regulation is required to authorize the use of ict in legislative activities and that trained human resources are necessary to address cyber-related errors resulting from external threats. Additionally, the adoption of ict should not be limited to digitizing legislative activities. It must be founded on the institution’s core business.
First record of three alien Auchenorrhyncha species from Europe: Acanalonia bivittata (Say, 1825), Branchana xanthota Li, 2011, and Dryadomorpha pallida Kirkaldy 1906 (Hemiptera: Auchenorrhyncha: Acanaloniidae, Cicadellidae)
Authors: SANNA FRANCESCO , POGGI FRANCESCO 
Published: October 2022

Three alien Auchenorrhyncha species are recorded for the first time from Europe (northern Italy): the Nearctic planthopper Acanalonia bivittata (Say, 1825), the Asian leafhopper Branchana xanthota Li, 2011, and the leafhopper Dryadomorpha pallida Kirkaldy 1906, present in the Afrotropical, Palearctic, Oriental and Australian regions. Observations on morphology and data on biology and host plants are provided. The 5th instar nymph of Dryadomorpha pallida is described.
Considerations and data about the increase of alien Auchenorrhyncha species in Europe are discussed.
Diurnal Variation of Precipitation over the High Mountain Asia: Spatial Distribution and Its Seasonality
Authors: Zhao Dingchi , Dong Wenhao , Lin Yanluan , Hu Yang , Cao Dianbin 
Published: October 2022

Abstract
Using abundant rainfall gauge measurements and Global Precipitation Mission (GPM) data, spatial patterns of rainfall diurnal cycles and their seasonality over high mountain Asia (HMA) were examined. Spatial distributions of rainfall diurnal cycles over the HMA have a prominent seasonality regulated by circulations at different spatiotemporal scales, within which large regional contrasts are embedded. Rainfall diurnal variability is relatively weak in the premonsoon season, with larger amplitude over the western HMA, the southeastern HMA, as well as southern periphery regions, characterized by a dominant late afternoon to morning rainfall preference. The pattern of rainfall spatial distributions is closely related to the midlatitude westerlies. Both the mean rainfall and amplitudes of diurnal cycles become more pronounced with the advance of monsoon season but weaken during postmonsoon. The widespread late afternoon to night pattern over HMA migrating with seasonal atmospheric circulation is consistent with the lifetime of convective systems, which become active from the afternoon due to radiative heating and decay during the night. Stationary terrain-dependent night-to-morning rainfall patterns are visible in those east–west-orientated valleys over HMA and the Qaidam basin throughout the seasons. This salient geographical dependence is associated with local circulation produced by the strong differential thermal conditions over mountains and valleys, which can lift the warm moist air at the mouth of the valley and trigger nocturnal convection.

Significance Statement
The main purpose of this study is to explore how spatial patterns of rainfall diurnal cycles over high mountain Asia vary with the seasons. Our results show that the widespread late afternoon to night rainfall over high mountain Asia migrating with seasonal atmospheric circulation is consistent with the lifetime of convective systems. Stationary terrain-dependent night-to-morning rainfall patterns are visible in those east–west-orientated valleys over high mountain Asia and the Qaidam basin throughout the seasons. These results highlight the importance of large-scale atmospheric circulation and local circulation on precipitation, which is critical for water resources over high mountain Asia.
Langmuir Circulations Transfer Kinetic Energy from Submesoscales and Larger Scales to Dissipative Scales
Authors: Hypolite Delphine , Romero Leonel , McWilliams James C. , Dauhajre Daniel P. 
Published: October 2022

Abstract
Surface gravity wave effects on currents (WEC) cause the emergence of Langmuir cells (LCs) in a suite of high horizontal resolution (Δx = 30 m), realistic oceanic simulations in the open ocean of central California. During large wave events, LCs develop widely but inhomogeneously, with larger vertical velocities in a deeper mixed layer. They interact with extant submesoscale currents. A 550-m horizontal spatial filter separates the signals of LCs and of submesoscale and larger-scale currents. The LCs have a strong velocity variance with small density gradient variance, while submesoscale currents are large in both. Using coarse graining, we show that WEC induces a forward cascade of kinetic energy in the upper ocean up to at least a 5-km scale. This is due to strong positive vertical Reynolds stress (in both the Eulerian and the Stokes drift energy production terms) at all resolved scales in the WEC solutions, associated with large vertical velocities. The spatial filter elucidates the role of LCs in generating the shear production on the vertical scale of Stokes drift (10 m), while submesoscale currents affect both the horizontal and vertical energy fluxes throughout the mixed layer (50–80 m). There is a slightly weaker forward cascade associated with nonhydrostatic LCs (by 13% in average) than in the hydrostatic case, but overall the simulation differences are small. A vertical mixing scheme K-profile parameterization (KPP) partially augmented by Langmuir turbulence yields wider LCs, which can lead to lower surface velocity gradients compared to solutions using the standard KPP scheme.
The Impact of Caprini Guideline Indicated Venous Thromboembolism Prophylaxis in Colorectal Surgery Patients: Experience of a Single Health System
Authors: Hyman David W. , Brennan Emily R. , Spaulding Aaron C. , Colibaseanu Dorin T. , Akram Hussain Md Walid , Muraleedharan Divya , Casler John D. , Schreier Diana J. , Thompson Kristine M. , Edwards Michael A. 
Published: October 2022

Background Venous thromboembolism (VTE) is the most common cause of preventable mortality following colorectal surgery (CRS), occurring in about 2% of patients. As a result, prophylaxis including discharge chemoprophylaxis is recommended. While VTE risk assessment tools are available, the consistent adoption and utilization of these tools remains elusive. Our study objectives were to determine the utilization and impact of risk adjusted VTE prophylaxis in CRS patients. Study Design CRS cases performed between 1/1/2016 and 5/31/2021 were retrospectively analyzed. Caprini score and implemented VTE prophylaxis measures were determined. The primary outcome measure was receiving Caprini guideline indicated VTE prophylaxis. Secondary outcomes included VTE and bleeding. Categorical variables were compared by chi-square and Fisher’s exact tests, and continuous variables by Kruskal-Wallis test. Logistic regression models were used to determine predictors of receiving appropriate VTE prophylaxis or experiencing postoperative VTE and bleeding. Results 10,422 CRS cases were analyzed and 90.6% were high risk for VTE. In-hospital appropriate prophylaxis rates in low, moderate, high, and very high-risk category patients were 91.2%, 56.1%, 61.0%, and 63.1%, respectively. Inpatient VTE was reduced by 75% in those receiving appropriate VTE prophylaxis. At discharge, 5.8% of patients received appropriate prophylaxis, in whom there were no VTE events at 30- and 90 days from discharge. Increasing Caprini score positively correlated with VTE risk in both the inpatient and discharge cohorts, but inversely correlated with the likelihood of receiving appropriate prophylaxis at discharge (OR .31, P <.0001). Conclusion Caprini guideline indicated VTE prophylaxis in CRS patients reduced VTE events without increasing bleeding complications.
Longitudinal Predictors of Informant-Rated Involvement of People with Dementia in Everyday Decision-Making: Findings from the IDEAL Program
Authors: Sabatini Serena , Martyr Anthony , Gamble Laura D. , Collins Rachel , Matthews Fiona E. , Morris Robin G. , Rusted Jennifer M. , Pentecost Claire , Quinn Catherine , Clare Linda ,   behalf of the IDEAL study team
Published: October 2022

The extent to which people with dementia are involved in everyday decision-making is unclear. We explored informant-rated involvement of people with dementia in everyday decision-making over 2 years and whether functional, behavioral, and psychological factors related to the person with dementia and the caregiver explain variability in involvement of people with dementia in everyday decision-making. We used IDEAL data for 1182 people with dementia and their caregivers. Baseline mean score on the decision-making involvement scale was 31/45; it minimally declined over time. People with dementia who were female, single, and/or whose caregiver was younger had greater involvement in everyday decision-making than those without these characteristics. Better cognition, fewer functional difficulties, fewer neuropsychiatric symptoms, less caregiver stress, and better informant-rated relationship quality were associated with higher involvement in everyday decision-making. Cognitive and functional rehabilitation, and educational resources for caregivers, could prolong involvement of people with dementia in everyday decision-making.
Opportunities for Community Pharmacists to Counsel Patients With Epilepsy and Seizure Clusters to Overcome Barriers and Foster Appropriate Treatment
Authors: Gidal Barry , Welty Timothy , Cokley Jon , Farrell Michelle , Shafer Patricia , Rabinowicz Adrian L. , Carrazana Enrique 
Published: October 2022

Some patients with epilepsy experience seizure clusters, which may be defined as 2 or more seizures occurring within 24 hours. Left untreated, seizure clusters increase the risk for physical injury and may progress to status epilepticus, irreversible neurologic injury, and death. Rescue therapy is based on benzodiazepine treatment. Prompt, appropriate use should be specified in patients’ individualized seizure action plans. Most seizure clusters occur outside the hospital setting. The ideal rescue therapy allows for easy and quick administration by a nonmedical person, which may minimize the need for intervention by emergency medical personnel or transportation to the hospital. In the 2 decades before the approval of 2 intranasal benzodiazepines in 2019 and 2020, rectal diazepam was the only route of administration approved by the US Food and Drug Administration specifically for seizure clusters. Each of the approved intranasal formulations has a unique profile. Both offer a convenient and socially acceptable route of administration. Recognition of seizure clusters and timing of proper administration are key to successful use of rescue therapy. Pharmacists’ counseling plays an important role in reinforcing when and how to appropriately administer rescue therapies and the importance of consistently using rescue treatment when indicated to promote effective management. This review includes resources for pharmacists, patients, and caregivers; reviews currently available treatments; and discusses seizure action plans that support effective treatment of seizure clusters.
Teaching through Pain: Finding Peace, of Sorts, after Unimaginable Loss
Authors: Wright Robin Redmon 
Published: October 2022

This evocative autoethnography is an exploration of learning and perseverance during a particularly dark time in my personal and professional life. In a period of just over 3 years, my spouse and I dealt with the need for several surgeries, the Covid-19-Delta pandemic and subsequent isolation, social unrest, an insurrection in the U.S., and the tragic death of our son. Then, the D.Ed. program in which I teach was closed. Through this writing, I attempt to make meaning from these events and to share what I have learned.
Cerebral blood flow alterations in migraine patients with and without aura: An arterial spin labeling study
Authors: Fu Tong , Liu Lindong , Huang Xiaobin , Zhang Di , Gao Yujia , Yin Xindao , Lin Hai , Dai Yongming , Wu Xinying 
Published: October 2022

Abstract
Background
Migraine aura is a transient, fully reversible visual, sensory, or other central nervous system symptom that classically precedes migraine headache. This study aimed to investigate cerebral blood flow (CBF) alterations of migraine with aura patients (MwA) and without aura patients (MwoA) during inter-ictal periods, using arterial spin labeling (ASL).

Methods
We evaluated 88 migraine patients (32 MwA) and 44 healthy control subjects (HC) who underwent a three-dimensional pseudo-continuous ASL MRI scanning. Voxel-based comparison of normalized CBF was conducted between MwA and MwoA. The relationship between CBF variation and clinical scale assessment was further analyzed. The mean CBF values in brain regions showed significant differences were calculated and considered as imaging features. Based on these features, different machine learning–based models were established to differentiate MwA and MwoA under five-fold cross validation. The predictive ability of the optimal model was further tested in an independent sample of 30 migraine patients (10 MwA).

Results
In comparison to MwoA and HC, MwA exhibited higher CBF levels in the bilateral superior frontal gyrus, bilateral postcentral gyrus and cerebellum, and lower CBF levels in the bilateral middle frontal gyrus, thalamus and medioventral occipital cortex (all p values < 0.05). These variations were also significantly correlated with multiple clinical rating scales about headache severity, quality of life and emotion. On basis of these CBF features, the accuracies and areas under curve of the final model in the training and testing samples were 84.3% and 0.872, 83.3% and 0.860 in discriminating patients with and without aura, respectively.

Conclusion
In this study, CBF abnormalities of MwA were identified in multiple brain regions, which might help better understand migraine-stroke connection mechanisms and may guide patient-specific decision-making.
lncRNA PVT1: a novel oncogene in multiple cancers
Authors: Li Ruiming , Wang Xia , Zhu Chunming , Wang Kefeng 
Published: October 2022

AbstractLong noncoding RNAs are involved in epigenetic gene modification, including binding to the chromatin rearrangement complex in pre-transcriptional regulation and to gene promoters in gene expression regulation, as well as acting as microRNA sponges to control messenger RNA levels in post-transcriptional regulation. An increasing number of studies have found that long noncoding RNA plasmacytoma variant translocation 1 (PVT1) plays an important role in cancer development. In this review of a large number of studies on PVT1, we found that PVT1 is closely related to tumor onset, proliferation, invasion, epithelial–mesenchymal transformation, and apoptosis, as well as poor prognosis and radiotherapy and chemotherapy resistance in some cancers. This review comprehensively describes PVT1 expression in various cancers and presents novel approaches to the diagnosis and treatment of cancer.
Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development
Authors: Xu Xiaohan , Tao Jing , Xing Anqi , Wu Zichen , Xu Yuqin , Sun Yi , Zhu Jiangyuan , Dai Xiang , Wang Yuhua 
Published: October 2022

Abstract
Background
Tea plant (Camellia sinensis (L.) O. Kuntze) is an important economic tea crop, but flowering will consume a lot of nutrients of C. sinensis, which will seriously affect the nutritional growth of C. sinensis. However, there are few studies on the development mechanism of C. sinensis flower, and most studies focus on a single C. sinensis cultivar.

Results
Here, we identified a 92-genes’ C. sinensis flower development core transcriptome from the transcriptome of three C. sinensis cultivars ('BaiYe1', 'HuangJinYa' and 'SuChaZao') in three developmental stages (bud stage, white bud stage and blooming stage). In addition, we also reveal the changes in endogenous hormone contents and the expression of genes related to synthesis and signal transduction during the development of C. sinensis flower. The results showed that most genes of the core transcriptome were involved in circadian rhythm and autonomous pathways. Moreover, there were only a few flowering time integrators, only 1 HD3A, 1 SOC1 and 1 LFY, and SOC1 played a dominant role in the development of C. sinensis flower. Furthermore, we screened out 217 differentially expressed genes related to plant hormone synthesis and 199 differentially expressed genes related to plant hormone signal transduction in C. sinensis flower development stage.

Conclusions
By constructing a complex hormone regulation network of C. sinensis flowering, we speculate that MYC, FT, SOC1 and LFY play key roles in the process of endogenous hormones regulating C. sinensis flowering development. The results of this study can a provide reference for the further study of C. sinensis flowering mechanism.