Effectiveness and Tolerance of Neoadjuvant Chemotherapy for Treatment of Locally Advanced Gastric Cancer
Authors: Van Tu Dao , Khac Dung Nguyen , Thi Ha Nguyen , Thi Thu Hien Tran , Thi Phuong Lan Nguyen 
Published: July 2022

This study aims to assess effectiveness and tolerance with neoadjuvant chemotherapy in patients with locally advanced gastric cancer in the period of 2018-2020. The study used the descriptive cross-sectional method to investigate 70 patients diagnosed with locally advanced gastric cancer, assigned to ECX/ECF or FLOT neoadjuvant chemotherapy regimens at Vietnam National Cancer Hospital. The results show that the partial response rates in the ECX/ECF and FLOT groups were 69.70% and 89.20%, respectively. There was no significant difference in the response level between the two groups (p = 0.716). 78.79% in the ECX/ECF group and 88.56% in the FLOT group underwent surgery. Neutropenia was an adverse event with the highest rate of grades 3 and 4 in both regimens (FLOT regimen was 10.81%, ECX/ECF regimen was 24.24%). There is a statistically significant difference in the incidence of events between the groups with prophylaxis and non-prophylaxis by granulocyte colony-stimulating factor. Taken together, there was no significant difference in the response level between the two groups; regarding the event of neutropenia, it could be controlled by prophylaxis in terms of benefits and risks for each patient.
Keywords:
Gastric cancer, effectiveness, safety, neoadjuvant chemotherapy.
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