bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tungsten-Steel Functionally Graded Coatings for Nuclear Fusion Applications Manufactured by Cold Gas Spraying
Authors: Mauer Georg , Rauwald Karl-Heinz , Sohn Yoo Jung 
Published: December 2022

AbstractIn nuclear fusion reactors, the first wall is the name given to the surface which is in direct contact with the plasma. A part of it is the divertor which is a device that removes fusion products from the plasma and impurities that have entered into it from the vessel lining. It is covered with water cooled tiles which have to withstand high temperatures and high heat fluxes. Moreover, resistance to neutron bombardment, low tritium absorption and low hydrogen permeation are additional demands. One materials concept under research is the application of a Reduced Activation Ferritic Martensitic Steel (RAFM) as a structural material with a tungsten protective coating. Since there is a considerable thermal mismatch between, a functional-graded materials concept was proposed.As the formation of undesired intermetallic Fe-W phases as well as oxidation should be avoided, cold gas spraying was chosen as manufacturing process. Two powder blends of EUROFER97 RAFM steel and a fine tungsten powder cut on the one hand and a coarser one on the other hand were tested in different ratios. The coatings were characterized with respect to their porosity and surface structure. Furthermore, the deposition efficiencies for steel and tungsten were determined each. It turned out that the deposition process is a complex mixed situation of bonding and erosion mechanisms as the deposition windows of these very different materials obviously diverge. Thus, a lower working gas temperature and pressure was advantageous in some cases. Unexpectedly, the coarser tungsten powder in general enabled to achieve better results.
Out-of-pocket payments and loss of income among long-term breast cancer survivors in Germany: a multi-regional population-based study
Authors: Schneider Jana , Hernandez Diego ,   CAESAR study group, Schlander Michael , Arndt Volker ,   on behalf of the CEASAR study group
Published: December 2022

Abstract

Purpose
This study aims to examine the magnitude of out of pocket (OOP) payments and income loss, as well as to identify socioeconomic and clinical factors among long-term breast cancer (BC) survivors in Germany.

Methods
We examine data from 2654 long-term BC survivors in Germany that participated in the “CAncEr Survivorship – A multi-Regional population-based study” (CAESAR) and who were at least 5 years post diagnosis. BC-related OOP payments and income loss both within the 12 months prior to the survey were analyzed. Two-part regression models were performed to identify socioeconomic and clinical factors.

Results
OOP payments were incurred by 51.9% of survivors with a total mean spending of 566 euros. Income loss was present among 9.6% of survivors and averaged 5463 euros among those reporting such. Socioeconomic and clinical factors associated with higher OOP payments (p ≤ 0.05) included age at time of diagnosis (65–79 years), education (10–11 years), (early) retirement, stage of diagnosis (stage III), time from diagnosis (more than 10 years), comorbidities (at least 1), and the use of rehabilitation services. Regarding income loss, age at time of diagnosis (50–59 years), (early) retirement, stage of diagnosis (stage II), time from diagnosis (5–7 years), comorbidities (at least 1), and receiving chemotherapy treatment were associated with higher losses.

Conclusions
For some survivors in Germany, financial burden can be considerably high despite comprehensive healthcare and support from social security.

Implications for Cancer Survivors
OOP payments related to domestic help and nursing staff as well as to outpatient care are most frequent.
Effects of gastric bypass surgery on brain connectivity responses to hypoglycemia
Authors: Fanni Giovanni , Kagios Christakis , Roman Erika , Sundbom Magnus , Wikström Johan , Haller Sven , Eriksson Jan W. 
Published: December 2022

Abstract
Introduction
Roux-en-Y gastric bypass (RYGB) leads to beneficial effects on glucose homeostasis, and attenuated hormonal counterregulatory responses to hypoglycemia are likely to contribute. RYGB also induces alterations in neural activity of cortical and subcortical brain regions. We aimed to characterize RYGB-induced changes in resting-state connectivity of specific brain regions of interest for energy homeostasis and behavioral control during hypoglycemia.

Method
Ten patients with BMI > 35 kg/m2 were investigated with brain PET/MR imaging during a hyperinsulinemic normo- and hypoglycemic clamp, before and 4 months after RYGB. Hormonal levels were assessed throughout the clamp. Resting-state (RS) fMRI scans were acquired in the glucose-lowering phase of the clamp, and they were analyzed with a seed-to-voxel approach.

Results
RS connectivity during initiation of hypoglycemia was significantly altered after RYGB between nucleus accumbens, thalamus, caudate, hypothalamus and their crosstalk with cortical and subcortical regions. Connectivity between the nucleus accumbens and the frontal pole was increased after RYGB, and this was associated with a reduction of ACTH (r = −0.639, p = 0.047) and cortisol (r = −0.635, p = 0.048) responses. Instead, connectivity between the caudate and the frontal pole after RYGB was reduced and this was associated with less attenuation of glucagon response during the hypoglycemic clamp (r = −0.728, p = 0.017), smaller reduction in fasting glucose (r = −0.798, p = 0.007) and less excess weight loss (r = 0.753, p = 0.012). No other significant associations were found between post-RYGB changes in ROI-to-voxel regional connectivity hormonal responses and metabolic or anthropometric outcomes.

Conclusion
RYGB alters brain connectivity during hypoglycemia of several neural pathways involved in reward, inhibitory control, and energy homeostasis. These changes are associated with altered hormonal responses to hypoglycemia and may be involved in the glucometabolic outcome of RYGB.
Endogenous hyperinsulinemic hypoglycemia: case series and literature review
Authors: Zhang Chenyang , Zhang Hui , Huang Wen 
Published: December 2022

Abstract
Purpose
Endogenous hyperinsulinemic hypoglycemia (EHH) is an uncommon disease characterized by inappropriately high plasma insulin levels despite low plasma glucose levels. Some rare etiologies can lead to EHH. Correct diagnosis is a prerequisite for treatment. Hence, although challenging, it is crucial for patients with EHH to identify the different causes.

Methods
We describe a case series of three patients, all of whom had obvious hypoglycemic symptoms and extraordinary hyperinsulinemia. Their plasma glucose, insulin, and C-peptide levels were tested simultaneously when hypoglycemia occurred. Moreover, other biochemical indices and relevant antibody levels were measured and imaging examinations were conducted.

Results
According to their medical history, physical examination, laboratory results, and imaging findings, the three patients were diagnosed with insulinoma, type B insulin resistance syndrome, and insulin autoimmune syndrome. After precise treatments, hypoglycemia was ultimately eliminated.

Conclusion
Although these diseases have similar symptoms and biochemical abnormalities, the treatment and prognosis are different. The case series presented here highlights the challenges in the differential diagnosis of EHH. An accurate diagnosis is necessary for hypoglycemia treatment.
Vasopressin induces apoptosis but does not enhance the antiproliferative effect of dynamin 2 or PI3K/Akt inhibition in luminal A breast cancer cells
Authors: Alkafaas Samar Sami , Loutfy Samah A. , Diab Thoria , Hessien Mohamed 
Published: December 2022

AbstractBreast cancer cells abnormally express vasopressin (AVP) and its receptors. The effect of AVP is largely orchestrated through its downstream signaling and by receptor-mediated endocytosis (RME), in which Dynamin 2 (Dyn2) plays an integral role in vesicle closure. In this work, luminal A breast cancer cells were treated with AVP, and then Dynasore (DYN) was employed to inhibit Dyn2 to explore the combined effect of AVP and Dyn2 inhibition on the survival of breast cancer cells. The results revealed that DYN alone demonstrated a concentration-dependent cytotoxic effect in AVP untreated cells. Apoptosis developed in 29.7 and 30.3% of cells treated with AVP or AVP+DYN, respectively, compared to 32.5% in cells treated with Wortmannin (Wort, a selective PI3K pathway inhibitor). More apoptosis was observed when cells were treated with DYN+Wort in presence or absence of exogenous AVP. Besides, 2 or 4- fold increases in the expression of Bax and Caspase-3, were observed in cells exposed to AVP in absence or presence of DYN, respectively. This was associated with higher levels of the autophagy marker (LC3II protein). Meanwhile, the activation of Akt protein, sequentially decreased in the same pattern. Cell’s invasion decreased when they were exposed to AVP alone or combined with DYN or/and Wort. Conclusively, although many reports suggested the proliferative effect of AVP, the results predict the antiproliferative and antimetastatic effects of 100 nM AVP in luminal A breast cancer cells. However, the hormone did not enhance the cytotoxic effect of Dyn 2 or PI3K pathway inhibition.
Graphical Abstract
Summary of the Dynamin 2 independent AVP antiproliferative effects. Breast cancer cells expresses AVP as a Prohormone (A). At high dose of AVP, the hormone is liganded with AVP receptor (B) to initiate RME, where the endosomed complex (C) is degraded through the endosome-lysosome system, as a part of signal management. These events consume soluble Dyn2 in neck closure and vesicle fission (D). This makes the cells more substitutable to the direct apoptotic effect of DYN (E). Alternatively, at lower AVP doses the liganded AVP may initiate cAMP-mediated downstream signaling (F) and cellular proliferation. In parallel, Wort inhibits PIP2-PIP3 conversion (G) and the subsequent inhibition of PI3K/Akt/mTOR pathway leading to cell death.
miR-200a-3p Regulates PRKACB and Participates in Aluminium-Induced Tau Phosphorylation in PC12 Cells
Authors: Li Huan , Liu Qun , Zhang Qinli , Xue Xingli , Zhang Jingsi , Zhang Jing , Lin Li , Niu Qiao 
Published: December 2022

AbstractAluminium (Al) is an environmental neurotoxin that humans are widely exposed to, but the molecular mechanism of its toxic effects is not fully understood. Many studies have shown that exposure to Al can cause abnormal phosphorylation of the tau protein that is believed as one of pathological features of Alzheimer’s disease. Increasing evidence indicates that microRNAs (miRNAs) may be involved in the pathological processes of neurodegenerative diseases and are potential regulatory factors for related target genes. Phosphorylation at Ser-133 of cAMP response element-binding protein (CREB) is one of the major pathways of CREB activation, and phosphorylation at this site is controlled by protein kinase A (PKA). The catalytic subunit of PKA, cAMP-dependent protein kinase catalytic subunit beta (PRKACB), phosphorylates CREB. The target gene prediction software TargetScan showed that PRKACB was one of the target mRNAs of miR-200a-3p. The purpose of this study was to investigate whether miR-200a-3p regulates the PKA/CREB pathway by targeting PRKACB and leads to abnormal phosphorylation of the tau protein in nerve cells. The results showed that Al exposure increased the expression level of miR-200a-3p, and miR-200a-3p increased the expression of targeted downregulated PRKACB, and then decreased the PKA/CREB signalling pathway activity, leading to abnormal hyperphosphorylation of tau.Graphical Abstract
Approaching predictors of success for sports clubs by applying the organizational capacity framework
Authors: Post Carina 
Published: December 2022

AbstractMany previous scientific investigations of sports clubs have lacked an appropriate approach for reflecting the diversity of sports-related organizations. The purpose of this paper is to measure sports clubs’ performance by considering the problems they experience. To perform this, the organizational capacity framework (OCF), which captures various internal and external resources possessed by organizations, is used to investigate various human, financial, and structural capacities of sports clubs located in Rhineland, Germany (n = 1000). This research also serves to test the organizational capacity framework’s applicability in this context. The results of multiple regression analysis showed that the framework is suitable for measuring the characteristics of sports clubs; however, further research is required to obtain more precise data. Regarding organizational problems, the present findings indicate that having sufficient board members, possessing good finances, and engaging in strategic planning are the factors with the greatest influence on reducing problems among sports clubs.
River flow prediction based on improved machine learning method: Cuckoo Search-Artificial Neural Network
Authors: Zanial Wan Norsyuhada Che Wan , Malek Marlinda Binti Abdul , Reba Mohd Nadzri Md , Zaini Nuratiah , Ahmed Ali Najah , Sherif Mohsen , Elshafie Ahmed 
Published: December 2022

AbstractOne of the largest hydropower facilities currently in operation in Malaysia is the Terengganu hydroelectric facility. As a result, for hydropower generation to be sustainable, future water availability in hydropower plants must be known. Therefore, it is necessary to precisely estimate how the river flow will alter as a result of changing rainfall patterns. Finding the best value for the hyper-parameters is one of the problems with machine learning algorithms, which have lately been adopted by many academics. In this research, Artificial Neural Network (ANN) is integrated with a nature-inspired optimizer, namely Cuckoo search algorithm (CS-ANN). The performance of the proposed algorithm then will be examined based on statistical indices namely Root-Mean-Square Error (RSME) and Determination Coefficient (R2). Then, the accuracy of the proposed model will be then examined with the stand-alone Artificial Neural Network (ANN). The statistical indices results indicate that the proposed Hybrid CS-ANN model showed an improvement based on R2 value as compared to ANN model with R2 of 0.900 at training stage and R2 of 0.935 at testing stage. RMSE value, for ANN model, is 127.79 m3/s for training stage and 12.7 m3/s at testing stage. While for the proposed Hybrid CS-ANN model, RMSE value is equal to 121.7 m3/s for training stage and 10.95 m3/s for testing stage. The results revealed that the proposed model outperformed the stand-alone model in predicting the river flow with high level of accuracy. Although the proposed model could be applied in different case study, there is a need to tune the model internal parameters when applied in different case study.
Pre-rainy Season Rainstorms in South China—Risk Perception of the 11 April 2019 Rainstorm in Shenzhen City
Authors: Sun Xuran , Zhou Wei , Zhang Guoming , Liu Lianyou , Wang Guangpeng , Xiang Mingzhu , Xiao Yuting , Qu Shufeng , Li Shouwei , Li Jiaxue 
Published: December 2022

AbstractWith the acceleration of urbanization in South China, rainstorms and floods are threatening the safety of people in urban areas. The 11 April 2019 (4·11 hereafter) rainstorm in Shenzhen City was a typical pre-rainy season rainstorm that caused great damage, yet such pre-rainy season events have not attracted sufficient attention in research. Risk perception of the public may indirectly affect their disaster preparedness, which is important for disaster management. In this study, we conducted a questionnaire survey that considered demographic factors and the level of risk perception, knowledge of risk, impact of the 4·11 rainstorm event on public risk perception, and degree of trust in the government. We used a two-factor model of risk perception to evaluate the factors that influenced public risk perception of the 4·11 rainstorm in Shenzhen. The main conclusions are: The 4·11 rainstorm improved public awareness of both risk and impact through the medium term, but the public’s perceived low probability of disaster occurrence and lack of knowledge of the pre-rainy season rainstorm phenomenon led to serious losses during this event. Although the public has high trust in the Shenzhen government, the management of rainstorm disasters in the pre-rainy season needs to be further improved.
A theoretical justification of the slip index concept in fretting analysis
Authors: Argatov Ivan I. , Chai Young S. 
Published: December 2022

AbstractFretting in the partial-slip and gross-slip regimes under a constant normal load is considered. The tangential force—displacement relations for the forward and backward motions are described based the generalized Cattaneo—Mindlin theory of tangential contact and Masing’s hypothesis on modelling the force—displacement hysteretic loop. Besides the critical force and displacement parameters (characterizing the triggering of sliding), the model includes one dimensionless fitting parameter that tunes the tangential contact stiffness of the friction—contact interface. Explicit expressions are derived for the main tribological parameters of the fretting loop, including the slip index and the signal index. The presented phenomenological modelling approach has been applied to the analysis of two sets of experimental data taken from the literature. It has been shown that the experimentally observed simple relation of a rational type between the slip index and the slip ratio corresponds to the gross-slip asymptotics of the corresponding model-based predicted relation. The known quantitative criteria for the transition from the partial slip regime to the gross slip regime are expressed in terms of the stiffness parameter, and a novel geometric transition criterion is formulated.
Blended Care Therapy for Depression and Anxiety: Outcomes across Diverse Racial and Ethnic Groups
Authors: Owusu Jocelynn T. , Wang Pam , Wickham Robert E. , Cottonham Danielle P. , Varra Alethea A. , Chen Connie , Lungu Anita 
Published: December 2022

Abstract

Background
Studies have reported positive outcomes of blended care therapy (BCT), which combines face-to-face care with internet modules. However, there is insufficient evidence of its effectiveness across racial and ethnic groups. This study evaluated outcomes of a BCT program, which combined video psychotherapy with internet cognitive-behavioral modules, across race and ethnicity.

Methods
Participants were 6492 adults, with elevated anxiety (Generalized Anxiety Disorder-7 [GAD-7] ≥ 8) and/or depression (Patient Health Questionnaire-9 [PHQ-9] ≥ 10) symptoms, enrolled in employer-offered BCT. Changes in anxiety (GAD-7) and depression (PHQ-9) symptoms during treatment were evaluated using individual growth curve models. Interaction terms of time with race and ethnicity tested for between-group differences. Treatment satisfaction was assessed using a Net Promoter measure (range = 1 (lowest satisfaction) to 5 (greatest satisfaction)).

Results
Participants’ self-reported race and ethnicity included Asian or Pacific Islander (27.5%), Black or African American (5.4%), Hispanic or Latino (9.3%), and White (47.2%). Anxiety symptoms decreased during treatment (p < 0.01), with greater reductions among Hispanic or Latino participants compared to White participants (p < 0.05). Depressive symptoms decreased across treatment (p < 0.01), with significantly greater decreases among some racial and ethnic groups compared to White participants. Declines in anxiety and depressive symptoms slowed across treatment (p’s < 0.01), with statistically significant differences in slowing rates of depressive symptoms across some racial and ethnic groups. Among participants with responses (28.45%), average treatment satisfaction ranged from 4.46 (SD = 0.73) to 4.67 (SD = 0.68) across race and ethnicity (p = 0.001). Racial and ethnic differences in outcomes were small in magnitude.

Conclusions
BCT for anxiety and depression can be effective across diverse racial and ethnic groups.
Policy decision of curling in real competition scenes
Authors: Xiao Qian , Li Zongmin , Wang Xiangdong , Liu Yujie , Li Yachuan , Yang Chaozhi , Li Feimo 
Published: December 2022

AbstractPolicy decision of curling refers to providing strategy suggestions for curling competition with the help of computers. Existing curling agents have achieved good results in the digital scenarios, but cannot make correct decisions when applied to actual competition and training scenes. In this paper, a strategies decision agent in the real scene has been proposed. The competition situation was acquired by a Situation-Aware Network and mapped by a Digital Extraction module. We designed Curling MCTS to explore the best strategy in continuous space. The effectiveness of our framework has been verified by experiments and evaluated by China’s wheelchair curling team at China Disabled Sports Management Center. With the help of our system, China’s wheelchair curling team trained effectively and won the championship in the XIII Paralympic Winter Games (2022, Beijing). In addition, a new curling target detection dataset was provided.
Facilitating Employee Recovery From Work: The Role of Leader-Member-Exchange
Authors: Volmer Judith , Schulte Eva-Maria , Fritz Charlotte 
Published: December 2022

AbstractBuilding on Affective Events Theory (AET), this study examined within-person relationships between employee perceptions of day-level leader-member exchange (LMX) and day-level positive affect as well as between positive affect and recovery from work in the evening (i.e., relaxation, mastery, control, and psychological detachment from work). In addition, LMX variability was examined as a moderator of these within-person relationships. Employees (N = 160) completed surveys at the end of the workday and in the evening across five consecutive workdays. Results indicate direct relationships between perceptions of LMX and employee positive affect at work. In addition, positive affect was positively associated with two of the four recovery experiences (mastery and relaxation). Furthermore, LMX variability across the workweek moderated these positive indirect effects such that the indirect associations between the perceptions of LMX and employees’ recovery experiences during the evening via positive affect was only positive when LMX variability was low. The indirect effects, however, were nonsignificant when LMX variability was moderate or high. The present study expands LMX research by adopting a dynamic within-person perspective and by connecting the literature on workplace leadership with the literature on recovery from work, indicating that perceptions of LMX can potentially impact employees’ nonwork time.
The Digital Euro and Energy Considerations: Can the ECB Introduce the Digital Euro Considering the Potential Energy Requirements?
Authors: Mooij Annelieke A.M. 
Published: December 2022

AbstractThe ECB has two mandates its primary and secondary mandate. Its primary mandate has been the focus of many discussions but its secondary mandate is less frequently discussed. Nevertheless this mandate has important objectives and should not be considered obsolete. This article examines the legal status of the secondary mandate of the ECB with regard to climate change. In particular this article will consider the role of the secondary mandate with regard to the Digital Euro and energy targets. The Digital Euro can be used as a monetary tool and improve payment systems. However, depending on its design the Digital Euro can use a considerable amount of energy. This article concludes that if the design of the Digital Euro does not impact the monetary objectives, the secondary mandate of the ECB determines the design of the Digital Euro.