bluuebunny/crossref_metadata_2025_split huggingface dataset:
The performance of [68Ga]Ga-FAPI-04 PET/CT in head and neck squamous cell carcinoma: a prospective comparison with [18F]FDG PET/CT
Authors: Jiang Yaqun , Wen Bing , Li Chongjiao , Tian Yueli , Xiao Zhiwei , Xu Kui , Xing Diankui , Yu Zili , Huang Jing , Jia Jun , He Yong 
Published: November 2022

Abstract
Purpose
This study aimed to compare the performance of [68Ga]Ga-FAPI-04 and [18F]FDG PET/CT for initial staging and recurrence detection of head and neck squamous cell carcinoma (HNSCC).
Methods
Prospectively, 77 patients with histologically proven or highly suspected HNSCC, who presented for either initial staging (n = 67) or restaging (n = 10), were referred to paired [18F]FDG and [68Ga]Ga-FAPI-04 PET/CT within one week. The diagnostic performance was compared for the two imaging approaches, especially for N staging. SUVmax, SUVmean, and target-to-background ratio (TBR) were assessed for paired positive lesions. Furthermore, change in management by [68Ga]Ga-FAPI-04 PET/CT and histopathologic FAP expression of some lesions were explored.
Results
[18F]FDG and [68Ga]Ga-FAPI-04 PET/CT exhibited comparable detection rates for primary tumors (100%) and recurrence (62.5%). In the twenty-nine patients receiving neck dissection, [68Ga]Ga-FAPI-04 PET/CT showed higher specificity and accuracy in evaluating preoperative N staging than [18F]FDG based on patients (p = 0.031 and p = 0.070), neck sides (p = 0.002 and p = 0.006) and neck levels (p < 0.001 and p < 0.001). As for distant metastasis, [68Ga]Ga-FAPI-04 PET/CT detected more positive lesions than [18F]FDG (25 vs 23), and with higher SUVmax (7.99 ± 9.04 vs 3.62 ± 2.68, p = 0.002) by the lesion-based analysis. The types of neck dissection in 9 cases (9/33) were altered by [68Ga]Ga-FAPI-04. Overall, clinical management was significantly changed in 10 patients (10/61). Three patients underwent a follow-up [68Ga]Ga-FAPI-04 PET/CT after neoadjuvant therapy: one showed complete remission, and the others showed progression. The [68Ga]Ga-FAPI-04 uptake intensity was confirmed to be consistent with FAP expression.
Conclusion
[68Ga]Ga-FAPI-04 outperforms [18F]FDG PET/CT in evaluating preoperative N staging in patients with HNSCC. Furthermore, [68Ga]Ga-FAPI-04 PET/CT also shows the potential in clinical management and monitoring response to treatment.
Clinical Trial Registration:
This prospective study was reviewed and approved by the Medical Ethics Committee of Zhongnan Hospital, Wuhan University, and was registered online at NIH ClinicalTrials.gov (NCT05034146 & NCT05030597).
Uveitis secondary to Whipple’s disease immune reconstitution inflammatory syndrome: a new entity ?
Authors: LEQUAIN Hippolyte , BRUNET Olivier , SEILLER Julien , ABUKHASHBAH Amro , BURILLON Carole , VIGNOT Emmanuelle , SEVE Pascal 
Published: November 2022

Abstract
Background: Whipple's disease is a rare infectious systemic condition caused by Tropheryma whipplei which, can involve several organs such as the gastrointestinal tract, joins, skin, central nervous system, and eyes. Because of its non-specific symptoms and frequent join involvement preceding other Whipple's disease symptoms, a relevant percentage of patients are treated as inflammatory arthritis and received immunosuppressive treatment such as tumor necrosis factor α inhibitors, associated with Immune Reconstitution Inflammatory Syndrome (IRIS), complicating antibiotic therapy.
Case presentation: A 53-year-old male presented with bilateral knee arthritis, a weight loss of 30 kg in 6 months without diarrhea, a chronic febricula at 38°C, and cognitive disorders. He was under treatment with tumor necrosis factor α for a misdiagnosis of presumed post-viral spondyloarthritis. Given the unusual clinical presentation for spondyloarthritis, further tests were performed as Polymerase Chain Reaction (PCR) in blood, saliva, stools, joint fluid of the left knee, and cerebrospinal fluid and revealing the presence of the T. whipplei genome, confirming the diagnosis of WD and antibiotic treatment was started. In addition, an ophthalmic examination revealed that the patient presented bilateral posterior uveitis and an aqueous humor sample confirmed the presence of T.whippley.
Thus, the patient was treated with classical Whipple’s disease therapy and subconjunctival corticosteroid injections. At three months, he presented persistent ocular posterior segment inflammation, leading to repeated PCR tests in blood, saliva, cerebrospinal fluid, stools, and aqueous humor, which were negatives. Therefore, an ocular IRIS was considered in the context of posterior uveitis recurrence after the effectiveness of antibiotic therapy and negative samples. Thus, the patient was treated with systemic corticosteroid therapy, allowing ocular inflammatory signs to disappear in both eyes.
Conclusions: This case revealed the existence of IRIS-induced uveitis complicating Whipple’s disease. Therefore, ophthalmologists, rheumatologists, and internists should be aware of this rare complication, particularly in the context of previous immunosuppressive therapy.
Filtration efficiency of medical and community face masks using viral and bacterial bioaerosols
Authors: DJEGHDIR Sana , PEYRON Aurélien , SARRY Gwendoline , LECLERC Lara , VERHOEVEN Paul O , POURCHEZ Jérémie 
Published: November 2022

Abstract
Face masks are often recommended in community settings to prevent the airborne transmission of respiratory viruses or bacteria. Our first objective was to develop an experimental bench to assess the viral filtration efficiency (VFE) of a mask with a methodology similar to the normative measurement of bacterial filtration efficiency (BFE) used to determine the filtration performance of medical masks. Then, using three categories of masks of increasing filtration quality (two types of community masks and one type of medical mask), filtration performances measured ranged from 61.4–98.8% of BFE and from 65.5–99.2% of VFE. A strong correlation (r = 0.983) between bacterial and viral filtration efficiency was observed for all types of masks and for the same droplets size in the 2–3 µm range. This result confirms the relevance of the EN14189:2019 standard using bacterial bioaerosols to evaluate mask filtration, to also extrapolate mask performances whatever their filtration quality against viral bioaerosols. Indeed, it appears that the filtration efficiency of masks (for micrometer droplet sizes and low bioaerosol exposure times) depends mainly on the size of the airborne droplet, rather than on the size of the infectious agent contained in that droplet.
Insular cortex to ventral striatum synapses encode valence of social interaction
Authors: Bellone Camilla , Espinosa Pedro , Girard Benoit , Lucchini Mattia , Campanelli Federica , Tiriticco Valentina 
Published: November 2022

Abstract
The decision to approach or avoid a conspecific is fundamental for survival. Affiliative
(prosocial) interactions favor approach behaviors, while antagonistic (aggressive) contacts trigger avoidance. Here we ask how the brain encodes the valence of social
interaction. We focused on the nucleus accumbens (NAc), a brain region implicated in social reward processing. We observed that social interactions activate D1-expressing medium spiny neurons (D1-MSNs) regardless of their valence. However, afferent D1-
expressing neurons of the anterior insular cortex (AIC) exhibited distinct activity patterns coding for prosocial and aggressive social interaction, respectively. As a result, distinct forms of synaptic plasticity were elicited at the AIC to NAc synapses. Thus, the valence of social interaction induces distinct neural activity in the AIC, which teaches the animal to approach and avoid conspecifics in the future.
Influences of lateral boundary forcings on the 2020 extreme Meiyu in the Yangtze-Huaihe River valley
Authors: Zhu Xiaoyu , Hu Yijia , Sun Xuguang , Zhong Zhong , Ha Yao 
Published: November 2022

AbstractIn this study, a Regional Climate Model (RegCM4.6) is employed to simulate the extreme Meiyu in the Yangtze-Huaihe River valley (YHRV) from June to July 2020. The influences of lateral boundary forcings in different directions on the 2020 Meiyu are explored through a series of sensitivity experiments with realistic or climatological lateral boundary conditions in the south, north and east directions, respectively. The results show that the 2020 Meiyu occurs under unique atmospheric forcings, and if all lateral boundary conditions are replaced by climatological mean state, heavy rainfall will not occur. Specifically, the south atmospheric signals provide moisture and heat for the occurrence of Meiyu. The atmospheric longwave activities in the north bring cold air to YHRV which can lift the warm air, provide instability conditions, and make the distribution of Meiyu similar to the teleconnection pattern of summer precipitation in East Asia. The western Pacific subtropical high (WPSH) in the east is important in anchoring the rainband locations in YHRV. In addition, the contributions of anomalous atmospheric signals in different directions change with time. Before June 10, the WPSH mainly contributes to the Meiyu evolution. From June 11 to July 3, the combined effects of forcings in the south and north are dominant. From July 3 to July 10, the cold air from the north plays a major role. After July 10, the 2020 atmospheric circulation conditions and Meiyu evolution are similar to the climatological mean state.
Transcriptional changes of tissue-specific genes in multiple endocrine organs: a study of lethal COVID-19 cases
Authors: Poma Anello Marcello , Bonuccelli Diana , Macerola Elisabetta , Niballi Sara , Basolo Alessio , Santini Ferruccio , Basolo Fulvio , Toniolo Antonio 
Published: November 2022

Abstract
Altered blood hormone and metabolite levels during and post-COVID-19 have been extensively reported. Yet, studies of gene expression at the tissue level that can help identify the causes of endocrine dysfunctions are scarce. We analyzed transcript levels of endocrine-specific genes in five endocrine organs of lethal COVID-19 cases. Overall, 116 autoptic specimens from 77 individuals (50 COVID-19 and 27 uninfected controls) were included. All samples were tested for SARS-CoV-2 genome. Investigated organs included adrenals, pancreas, ovary, thyroid and white adipose tissue (WAT). Transcript levels of 42 endocrine-specific and 3 IFN-stimulated genes (ISGs) were measured and compared between COVID-19 cases (virus-positive and virus-negative in tissue) and uninfected controls. ISG transcript levels were enhanced in tissues positive for SARS-CoV-2. Endocrine-specific genes (e.g., HSD3B2, INS, IAPP, TSHR, FOXE1, LEP, CRYGD) were deregulated in COVID-19 cases in an organ-specific manner. Transcription of organ-specific genes was suppressed in virus-positive specimens of ovary, pancreas and thyroid but enhanced in adrenals. In WAT of COVID-19 cases transcription of ISGs and leptin was enhanced independently of the presence of virus. Our findings suggest that, in COVID-19, endocrine dysfunctions may arise especially when SARS-CoV-2 invades endocrine organs and that transcriptional alterations of endocrine-specific genes may contribute to endocrine manifestations.
Leishmania infantum chagasi detection in blood donors living in an endemic area
Authors: Lopes Elizandra Aparecida de Oliveira , Florencio-Henschel Patrícia , Jordão Felipe Trovalim , Sperança Márcia Aparecida , Martins Luciamare Perinetti Alves , Suzuki Rodrigo Buzinaro 
Published: November 2022

Abstract
Human Visceral Leishmaniasis (HVL) is a neglected disease that occurs in 98 countries on five continents, and it is endemic in tropical and subtropical regions. In South America, the etiological agent of HVL is Leishmania infantum chagasi, mainly transmitted through the bite of an infected sandfly female from the genus Lutzomyia. In American HVL endemic areas, is common the occurrence of asymptomatic infection, which contribute with the possibility of L. infantum chagasi transmission during a blood transfusion. To know the prevalence of L. infantum chagasi asymptomatic infection in blood donors from the microregion of Adamantina, we investigated 324 peripheral blood samples from donors through Immunofluorescence (IFAT) and PCR-RFLP techniques. Seven blood samples (2.16%) tested positive for Leishmania by IFAT, and from that six presented positive results by PCR (85.71%), which were later identified as L. infantum chagasi by RFLP. The presence of L. infantum chagasi in the peripheral blood of blood donors supported the hypothesis of transmission by blood transfusion and points to the need to include tests for visceral leishmaniasis in blood bank screening tests and pre-storage measures, especially in endemic areas to prevent the exponential increase of HVL by blood transfusion.
Constructed wetlands as treatment systems: An overview and bibliometric analysis
Authors: Reshadi Mir Amir Mohammad , Sabour Mohammad Reza , Mojtahedi Alireza 
Published: November 2022

Abstract
Constructed wetlands have gained a major role in treating various forms of wastewaters. According to their cost-effectiveness and myriads of side benefits, a substantial body of research has grown around this topic in recent years. Being situated at the center of studies from diverse fields, there is a demand for a study to show different themes inside this field of research. This paper aims to explore research connected to the application of constructed wetlands for water and wastewater treatment using bibliometric analysis of data retrieved from Scopus database from the first appearance of this topic to 2021. The results suggest that more than three thousand papers have been published by 503 journals. About 8000 scholars have contributed to this topic, who are mostly from China, United States, United Kingdom, Spain, and India. The analysis on author keywords interaction network found 4 major clusters, each indicating to various parts of research on constructed wetlands. Finally, most recent research trends were detected via overlay network, indicating the focus on micropollutants and emerging contaminants (such as antibiotics) and microbial fuel cells as trends of future study in this field.
Evaluation of the usefulness of a paper–pencil group cognitive assessment for older adults in the community
Authors: Cho Daisuke , Suzuki Hiroyuki , Ogawa Susumu , Takahashi Tomoya , Sato Kenichiro , Iizuka Ai , Kobayashi Momoko , Yamauchi Misako , Kinai Anna , Li Yan , Fujiwara Yoshinori 
Published: November 2022

Abstract
Background
As the older population increases, the need for early detection of cognitive decline is also increasing. In this study, we examined whether our paper–pencil type group examination for cognitive assessment (PAPLICA) could detect the effects of years of education and aging.
Methods
PAPLICA was conducted on 829 older people. One examiner conducted the test on a group of approxmately 10–20 people in approximately 25 minutes. Participants were briefed on tackling the issues projected on the projector, and their answers were recorded in a response booklet.
Results
An independent samples t-test was performed for years of education, and ANCOVA was performed for aging. Analysis results indicate that the newer tests were generally able to detect the effects of years of education and aging, but the detection of the effects of aging varied from test to test.
Conclusions
The PAPLICA, similar to other neuropsychological tests, was able to detect the effects of years of education and aging. Future testing should be conducted on different demographics to identify the differences in patterns of cognitive decline.
The role of female managers in enhancing employee well-being: A path through workplace resources
Authors: Xie Jun , Piao Xiangdan , Managi Shunsuke 
Published: November 2022

Abstract
Following the job demands-resources theory, this study explores how female managers affect employee well-being through multiple levels of workplace resources, including task, group, and worksite levels. The test is based on a large-scale job stress survey of around 96,000 employee-year observations from 2017 to 2019. The structural equational model is applied to construct the latent variables of workplace resources at each level and test the mediating effects. The findings give supporting evidence for the transformational leadership behaviors of female managers. The female presence at the management level is associated with better workplace resources and employee well-being, especially workplace cohesiveness, work engagement, and occupational stress. Workplace resources significantly mediate these relationships, which shed light on the underlying mechanisms. Notably, the positive indirect effects via workplace resources could offset the negative direct effects of female managers. Female middle managers present more substantial impacts than top managers, providing further implications for gender diversity issues in management teams.
A rare case of mimicry of insulinoma: presenting mainly in terms of clinical symptoms, imaging and molecular markers
Authors: Yi Zhiqiang , Gu Jin , Li Taolang , Yao Jin , Wang Jinjing , Chen Hua , Mei Zanzan , Wu Huichao , Li Hongping , Ma Zhiyuan , Deng Zilin , Tuo Biguang , Zhao Lijing , Liu Xuemei 
Published: November 2022

Abstract
Background

Nesidioblastosis and insulinomas are caused by dysfunctional β cells, which in turn can cause endogenous hyperinsulinemia. In adults, the clinical and histomorphological features of nesidioblastosis and insulinoma may be remarkably similar, implying that it can be difficult to differentiate the two entities with preoperative biochemical and diagnostic imaging.

Case presentation

We report a 48-year-old man diagnosed with adult focal nesidioblastosis. We used contrast-enhanced magnetic resonance imaging (ceMRI), [68Ga]-DOTATATE positron-emission tomography/computed tomography (PET/CT), endoscopic ultrasonography (EUS)-guided fine-needle aspiration (FNA) and other tests before surgery, all of which highly suggested insulinoma. However, the final pathological diagnosis was focal neuroblastoma.

Conclusion

Adult focal nesidioblastosis is very rare. In this case, we focused on differentiating focal nesidioblastosis from insulinoma. We reviewed relevant literature reports and found that it is sometimes difficult to differentiate the two diseases with the results of preoperative examinations. For pancreatic space-occupying lesions that can clinically present as either of these two diseases, the focus should be on distinguishing between the presence and absence of metastases as well as precise pancreatic localization.
Along-Strike Forearc and Subducted Upper Slab Structure beneath North Chile and their Implications towards occurrence of Slow Slip
Authors: Mukherjee Pousali , Ito Yoshihiro , Borah Kajaljyoti , Mpuang Admore Phindani , Garcia Emmanuel Soliman , Plata-Martinez Raymundo 
Published: November 2022

Abstract
We estimated the lithospheric structure beneath the forearc of North Chile subduction zone, extending from Iquique to Valparaiso, with overlapping slow slip areas. Thickness and velocity of subducted oceanic crust, slab top, subducted oceanic Moho, continental Moho, and wedge mantle velocity were computed. We investigated relative differences of seismic velocities around plate interface, especially from lower wedge mantle bottom, upper subducted oceanic crust and oceanic mantle, near and away from the slow slip areas. Here we show that the disparities were more pronounced near south of Iquique szone (19oS-25oS). Near Valparaiso, the velocities of upper oceanic mantle differ. These discrepancies in velocities are regarded as presence of fluids from subducted ridges and seamounts, which might alter seismicity in the area. We hypothesize that seismological structure could potentially regulate slow slip in Iquique, as a combined effect from lower wedge mantle, oceanic crust, and subducting mantle.
Probing the binding behavior and kinetic studies of amphiphilic acrylate copolymers with bovine serum albumin
Authors: Mushtaq Shehla , Abbas Muhammad Asad , Nasir Habib , Mahmood Azhar , Iqbal Mudassir , Janjua Hussnain A. , Ahmad Nasir M. 
Published: November 2022

Abstract
In this study, a series of copolymers poly(methyl methacrylate) (pMMA), poly(3-sulfopropyl methacrylate-co-methyl methacrylate) p(SPMA-co-MMA), and poly(dimethylaminoethyl methacrylate-co-methyl methacrylae) p(DMAEMA-co-MMA) were synthesized via free radical polymerization and the impact of surface charge on amphiphilic copolymers and its interactions with the bovine serum albumin (BSA) was studied. These amphiphilic copolymers are thermally stable at 100 oC and with Tg 82 and 132 oC. These copolymers pMD1 and pMS1 have -56.6 and -72.6 mV at pH 7.4 in PBS buffer solution that controls bovine serum albumin (BSA) adsorption capacity on polymers surface. AFM analysis further confirm minimum BSA film thickness of 0.474 and 0.324 nm for pMD1 and pMS1 as compared to pMMA. BSA adsorption for pMD1 and pMS1 was 0.9 and 1.5 mg/g while kinetic studies shown the suitability of best fitting of pseudo-first-order model that showed physisorption which was attained at pH 7.4 within 24 hours at 25oC.
The etiology and prognosis of non-traumatic impaired consciousness in patients admitted to the emergency department: a prospective cohort study
Authors: Sharifi Mohammad Davood , Vafadar Elnaz , Foroughian Mahdi , Esfahani Golnaz Latifian , Torshizian Ashkan 
Published: November 2022

Abstract
Background and aim
Altered level of consciousness(LOC) is a common complaint in patients admitted to the emergency department(ED). Altered LOC occurs with various causes. Emergent diagnosis and treatment of patients with altered LOC are vital to prevent irreversible brain damage. In this study, we aimed to acquire a better vision of non-traumatic altered LOC’s prevalent etiologies. The association between patients’ initial condition and survival was also assessed.
Methods
This prospective cohort study enrolled 1000 patients with altered LOC referred to two tertiary hospitals in 2020 and 2021. Patients with ALOC who had GCS < 14, and a final diagnosis, were included and followed for a month. We also collected all initial data gathered by ED triage and investigated the association of these entities with survival and their distribution among different final diagnoses.
Results
We studied 1000 patients. 52.4% of the population consisted of males. The mean age was 59.85 ± 16.06. Sepsis(38.3%) was the most common etiology, followed by: stroke(9.2%), heart failure(8%), myocardial infarction(7.3%), meningitis(7.2%), hepatic encephalopathy(6.5%) and alcohol intoxication(5.8%). Deceased patients had higher pulse rates(P = .030) and lower blood glucose(P = .049) and blood pressure(P = .001) at admission. Prior history of stroke(P = .003) and hyperlipidemia(P = .012) were associated with reduced survival odds.
Conclusion
Our data reveal high one-month mortality(56%) in patients with altered LOC. Also, patients with hyperlipidemia and a history of previous stroke seem to have worse outcomes. Due to this high mortality rate, patients with altered LOC should be treated intensively and prioritized, especially in crowded EDs.