bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indoor environmental quality-based space categorization framework: the case of health-care facilities
Authors: Budaiwi Ismail Mohammed , Mohammed Mohammed Alhaji , Harbi Hammad Ali 
Published: September 2022

Purpose
Indoor environmental quality (IEQ) in buildings has an impact on people’s health, productivity and comfort. Maintaining the highest possible IEQ level in complex buildings, such as health care, is difficult due to economic and organizational constraints. This study aims to categorize the vicinities in a typical health-care facility in terms of importance and criticality in relation to the various IEQ factors, as well as to develop an IEQ assessment procedure.

Design/methodology/approach
A comprehensive literature review, established standards and structured interviews with industrial hygiene professionals in health-care settings were used in this study. To test the applicability of the developed IEQ assessment procedure, a pilot study was conducted in an existing health-care facility.

Findings
This study categorized health-care facilities into various vicinities and discovered three respondents group had varying IEQ perceptions (facility managers, environmental health specialists and nurses). According to the findings, indoor air quality is the most important and dominant factor influencing overall IEQ in health-care facilities. The trial application of the framework shows that much work is needed to improve the level of response and readiness of facility management and occupants to allow for the effective use of the developed procedure.

Originality/value
Previous research did not include a detailed categorization of vicinities in health-care buildings based on IEQ requirements. The findings of this study will help to close this knowledge gap and guide facility managers and operators in recognizing the relative importance of different IEQ factors, maintaining functional requirements and identifying priorities when developing maintenance and operational procedures and allocating resources.
The moderating effect of managerial discretion on cross-border knowledge search and the innovation quality of high-tech firms in a global health emergency: evidence from China
Authors: Duan Yunlong , Liu Shuling , MU Chang , Liu Xiangwei , Cheng Edwin , Liu Yongsong 
Published: September 2022

PurposeThis study aims to analyze the moderating effect of managerial discretion on the relationship between cross-border knowledge search and the high-tech firms’ innovation quality in a global health emergency and addresses the following issues: the influence mechanism of different types of cross-border knowledge search on the high-tech firms’ innovation quality in a global health emergency; and the moderating role of different dimensions of manager discretion on the above relationship.Design/methodology/approachBased on the firms’ strategy selection methods, the authors divided cross-border knowledge search into three aspects, namely, breadth, depth and balance, and analyzed the impact of cross-border knowledge search on the innovation quality of high-tech firms in a global health emergency, taking managerial discretion as the moderating variable, and divided it into position rights, pay rights and operation rights according to the key rights of firms’ strategic management. Furthermore, the authors constructed a theoretical model, and for an analysis sample, the authors collected data from Chinese high-tech firms from 2013 to 2021.FindingsThe empirical results show that there is an inverted U-shaped relationship between cross-border knowledge search breadth, depth and balance and the innovation quality of high-tech firms. The position rights, pay rights and operation rights of managerial discretion have partially significant moderating effects on the relationship between cross-border knowledge search breadth, depth and balance and the high-tech firms’ innovation quality.Originality/valueConsiderable literature has grown around the theme of the impact of knowledge search on the firms’ innovation quality. Nevertheless, only a few studies draw on the combination of global health emergency, cross-border knowledge search and the innovation quality; in particular, no literature has analyzed the relationship between the three from the managerial discretion perspective. Exploring the above relationships has great theoretical value for enriching and improving knowledge management and innovation management theories and provides a theoretical basis and practical support for high-tech firms to face challenges of a global health emergency and to break through the innovation dilemma.
Randomised controlled trial: effects of gluten‐free diet on symptoms and the gut microenvironment in irritable bowel syndrome
Authors: Algera Joost P. , Magnusson Maria K. , Öhman Lena , Störsrud Stine , Simrén Magnus , Törnblom Hans 
Published: September 2022

SummaryBackgroundA gluten‐free diet reduces symptoms in some patients with irritable bowel syndrome (IBS) through unclear mechanisms.AimsTo assess the effects of gluten‐free versus gluten‐containing diet on symptoms and the gut microenvironment, and to identify predictors of response to the gluten‐free diet in IBSMethodsTwenty patients with IBS and 18 healthy controls (HC) followed a gluten‐free diet during two 14‐day intervention periods where they sprinkled either gluten (14 g/day) or rice flour powder over their meals. Primary outcomes included effects of the interventions on IBS symptoms (IBS‐SSS) and bowel habits. Secondary outcomes included effects of gluten‐free diet on faecal microbiota and metabolite profile.ResultsIBS symptoms improved during the gluten‐free (p = 0.02), but not the gluten‐containing period, with no difference between the interventions. IBS patients reported fewer loose stools during the gluten‐free intervention (p = 0.01). Patients with IBS and HC presented distinct metabolite profiles based on the effects of the gluten‐free diet (p < 0.001). True responders (reduced IBS‐SSS by ≥50 solely after gluten‐free period) and non‐responders were discriminated based on the effects of the gluten‐free diet on the microbiota (p < 0.01) and metabolite profiles (p < 0.001). The response to the gluten‐free diet could be predicted by the metabolite profile before the intervention (p < 0.001).ConclusionsA gluten‐free diet may influence symptoms in a subset of patients with IBS, with a particular effect on bowel habits. A gluten‐free diet seems to impact the gut microenvironment. Responsiveness to the gluten‐free diet may be predicted by the metabolite profile. Clinicaltrials.gov: NCT03869359.
Effect of compassion‐focused therapy on self‐criticism and self‐soothing: A meta‐analysis
Authors: Vidal Joana , Soldevilla Joan Miquel 
Published: September 2022

AbstractObjectiveCompassion is oriented towards perceiving and relieving suffering. Hence, its development is beneficial for mental health. Many interventions aimed at cultivating compassion in patients have been empirically supported. This meta‐analysis analyses the effectiveness of compassion‐focused therapy (CFT) in decreasing self‐criticism, a vulnerability factor that has been related to several mental health problems, and in increasing self‐soothing.MethodsA literature search was conducted in the PsycInfo, Web of Science, Medline and Scopus databases, through which 7 controlled trials (N = 640) and 7 observational studies (N = 207) were retrieved.ResultsThe results of the meta‐analysis determine that CFT decreases the level of self‐criticism and increases the ability to experience soothing. The size of the effect varies depending on the design of the study and the subscale of the test used to measure self‐criticism (Forms of Self‐Criticizing/Attacking and Self‐Reassuring Scale).ConclusionsCFT has proven to be an effective intervention for reducing self‐criticism. However, given that the number of studies is small and that only half of them are controlled trials, the results must be interpreted cautiously. More randomized controlled trials comparing CFT with other therapies are needed to determine the effect of this intervention on self‐criticism with more scientific evidence.
Challenges of vaccination and herd immunity in COVID‐19 and management strategies
Authors: She Jun , Hou Dongni , Chen Cuicui , Bi Jing , Song Yuanlin 
Published: September 2022

AbstractCoronavirus disease 2019 (COVID‐19), the highly contagious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has spread worldwide with millions of cases and more than 5 million deaths to date. SARS‐CoV‐2 has caused serious damage all over the world with many countries experiencing the third or the fourth wave of the viral disease outbreaks, mainly due to the emergence of mutant variants. Those who unvaccinated remain most vulnerable to COVID‐19 and its variants. COVID‐19 vaccination, along with prevention strategies, is a critical measure to defense against the disease. COVID‐19 vaccination can reduce the spread of virus and help protect susceptible population. Although herd immunity might not be realized solely by vaccination, COVID‐19 vaccines have been proved to be effective in reducing the risk of severe disease, hospitalization, and even death. It is recommended that people get vaccinated as soon as they are eligible. This review summarizes the recent SARS‐CoV‐2 variants that brought challenges for vaccination and herd immunity and discusses promising management strategies.
Liquid biopsy‐based targeted gene screening highlights tumor cell subtypes in patients with advanced prostate cancer
Authors: Derderian Seta , Vesval Quentin , Wissing Michel D. , Hamel Lucie , Côté Nathalie , Vanhuyse Marie , Ferrario Cristiano , Bladou Franck , Aprikian Armen , Chevalier Simone 
Published: September 2022

AbstractProstate cancer (PCa) clinical heterogeneity underscores tumor heterogeneity, which may be best defined by cell subtypes. To test if cell subtypes contributing to progression can be assessed noninvasively, we investigated whether 14 genes representing luminal, neuroendocrine, and stem cells are detectable in whole blood RNA of patients with advanced PCa. For each gene, reverse transcription quantitative polymerase chain reaction assays were first validated using RNA from PCa cell lines, and their traceability in blood was assessed in cell spiking experiments. These were next tested in blood RNA of 40 advanced PCa cases and 40 healthy controls. Expression in controls, which was low or negative, was used to define stringent thresholds for gene overexpression in patients to account for normal variation in white blood cells. Thirty‐five of 40 patients overexpressed at least one gene. Patients with more genes overexpressed had a higher risk of death (hazard ratio 1.42, range 1.12–1.77). Progression on androgen receptor inhibitors was associated with overexpression of stem (odds ratio [OR] 7.74, range 1.68–35.61) and neuroendocrine (OR 13.10, range 1.24–142.34) genes, while luminal genes were associated with taxanes (OR 2.7, range 1.07–6.82). Analyses in PCa transcriptomic datasets revealed that this gene panel was most prominent in metastases of advanced disease, with diversity among patients. Collectively, these findings support the contribution of the prostate cell subtypes to disease progression. Cell‐subtype specific genes are traceable in blood RNA of patients with advanced PCa and are associated with clinically relevant end points. This opens the door to minimally invasive liquid biopsies for better management of this deadly disease.
Publicly subsidised smoking cessation medicines in times of COVID‐19 in Australia: An interrupted time series analysis
Authors: Baliunas Dolly , Gartner Coral , Hollingworth Samantha A. , Sullivan Clair , Comans Tracy , Pole Jason D. 
Published: September 2022

AbstractIntroductionIn Australia, the available published literature demonstrated a spike in dispensed prescription medicines after the onset of the COVID‐19 pandemic that subsequently returned to expected levels. Smoking cessation medicines may not follow this pattern because quit attempts are influenced by a range of factors. Knowledge of whether dispensing of these medicines has changed since the pandemic is lacking. We explored the change in dispensing of publicly subsidised smoking cessation medicines since the pandemic.MethodsAustralia's universal health‐care system provides access to government‐subsidised medicines via the Pharmaceutical Benefits Scheme and records of dispensed medicines are publicly available on a nationally aggregated level. We retrieved Pharmaceutical Benefits Scheme data from January 2016 to January 2021. We used interrupted time series modelling to quantify the impact of COVID‐19 on dispensing of nicotine replacement therapy (NRT) patches, varenicline and all smoking cessation treatments combined separately.ResultsAfter an initial spike in medicines at the onset of the pandemic, the monthly rate of prescriptions dispensed for varenicline was predominantly within predicted ranges, while that of NRT patches was predominantly below predicted ranges.Discussion and ConclusionsThere has been a differential change in the number of subsidised smoking cessation medicines supplied in Australia since the COVID‐19 pandemic, with varenicline prescriptions largely within, and NRT patches largely lower than, expected ranges. The reasons for the apparent change in dispensing of subsidised smoking cessation medicines are unclear.
“Spread too thin”: Parents' experiences of burnout during COVID‐19 in Australia
Authors: Wiemer Samira , Clarkson Larissa 
Published: September 2022

AbstractObjectiveWe aimed to investigate parental burnout (PB) within an Australian context during COVID‐19.BackgroundLittle is known about how the increase in the parental burden created by COVID‐19 restrictions has affected parents and whether this has resulted in increased PB.MethodA mixed‐methods approach examined PB in a sample of Australian parents (N = 403) during COVID‐19. Regression analyses were conducted to identify predictors of PB, and multivariate analysis of covariance (MANCOVA) was used to compare PB scores to scores collected prior to COVID‐19. Thematic analysis was used to understand the qualitative experience of parenting during lockdowns.ResultsPB scores obtained during COVID‐19 were significantly higher than pre–COVID‐19, and prevalence of PB almost doubled. Age of the parent was the most significant predictor of PB, although gender of the parent, average age of children, and number of children were also predictors on the PB subscales. Qualitatively, parents reported increased stress and a loss of coping mechanisms during lockdown, and this commonly led to negative outcomes.ConclusionResults suggest that parents struggled to cope with the additional responsibilities and the reductions to resources created by COVID‐19 restrictions.ImplicationsThese findings support researchers globally who call for interventions that support parents during periods of COVID‐19 restrictions.
Effect of absorbed power and dopant content on densification during rapid microwave sintering of Bi2O3‐doped ZnO
Authors: Egorov Sergei V. , Eremeev Anatoly G. , Kholoptsev Vladislav V. , Plotnikov Ivan V. , Rybakov Kirill I. , Sorokin Andrei A. , Rostokina Elena Ye. , Balabanov Stanislav S. 
Published: September 2022

AbstractZnO samples with an addition of 0, 0.035, 0.1, and 0.35 mol.% Bi2O3were microwave sintered at heating rates 10 and 50°C/min to a maximum temperature of 1200°C with zero hold time. The densification curves obtained by optical dilatometry have been studied in their dependence on the dopant concentration and the heating rate. Direct volumetric absorption of microwave radiation resulted in a 50–60°C shift of the densification curves toward low temperatures compared to susceptor‐assisted heating. An analysis of the effect of the volumetrically absorbed microwave power on the formation of grain‐boundary phases that facilitate densification is presented.
Collateralized Loan Obligations: A Primer
Authors: Martin John , Sayrak Akin 
Published: September 2022

In recent years, collateralized loan obligations, or CLOs, have become the largest nonbank lender in the U.S. This added source of financing, which lies outside the purview of banking regulation, has given rise to the concept of a “shadow banking system.” And the lack of transparency and regulatory oversight of CLOs and shadow banking have led to concern that this growing market might contribute to a financial crisis similar to the GFC of 2007‐2008, which was triggered by the securitization of subprime mortgages.The authors provide a first look at CLOs and their distinctive features as a securitization vehicle that allowed them not only to weather the 2007‐2008 financial crisis but to thrive in the post‐GFC world. Though the collateral performance of CLOs suffered during GFC, their recovery was faster and stronger than that of mortgage‐backed CDOs. Furthermore, the return performance of CLO tranches has in general also been superior to the returns from the comparable leveraged loans upon which CLOs are based—though there are difficulties in measuring returns for CLO tranches since transaction prices are not public information, especially in the case of the equity tranche.After describing their remarkable growth, the authors focus on two fundamental risks posed by CLOs. The first risk relates to the reliability of credit ratings—though it's important to note that the extensive due diligence behind leverage loans versus mortgage loans effectively reduces CLO investors' reliance on the rating agencies. The second risk relates to the systematic risk borne by the CLO investors, which is lower than that of MBS if only by virtue of the fact that CLOs are based on shorter‐term floating rate instruments than 30‐year mortgages. More important, what happens in most MBS, CLO managers can actively manage their loan portfolios in the secondary markets, and effective and active management of collateral works to limit both default risk and the possible effects of systemic shocks.
Do You Really Know Your Cost of Capital?
Authors: Keloharju Matti , Linnainmaa Juhani , Nyberg Peter 
Published: September 2022

We argue that the cost of equity capital varies much less across firms than previously thought. We find that expected return differences across stocks are short term in nature and become empirically indistinguishable from zero in five years. When we aggregate expected returns over longer periods of time, our results translate into 99% of the firms having their cost of equity within 1% of the market‐wide average. The amount of variation in the cost of capital implied by these results is of the order of one‐fifth or perhaps only of one‐tenth of the variation in firms' discount rates indicated by surveys. Our results suggest that high‐risk firms apply much higher, and low‐risk firms much lower, discount rates than they should.Why do differences in firms' cost of equity capital converge in just a few years? This is because the differences in firm characteristics translating into cost of equity differences vanish over time. For example, competition in the product market makes it hard for profitable firms to maintain their edge, allowing less profitable firms to catch up. As a result, firms representing different levels of risk can, over time, be expected to become more like one another. Some differences in firm characteristics, such as in the ratio of the book and market value of equity, can also stem from the mispricing of stocks. Financial markets are arguably more efficient than product markets, so potential differences in mispricing can be expected to converge even faster than differences in firm characteristics.
Quality assessment of consumer‐facing websites on sodium reduction
Authors: Hussain Tasfia , Ahmedna Taha , Marklund Matti , Appel Lawrence J. , Henry Megan E. 
Published: September 2022

AbstractThe purpose of this paper is to evaluate the quality of information and guidance on dietary sodium reduction available on consumer‐facing websites. Google Trends was used to identify the five most‐used search terms related to dietary sodium reduction. For each term, websites on the first two pages were collected (n = 18–20). Of 93 websites collected, 24 were excluded due to defective links, duplicate websites, or not being consumer‐focused. The remaining 69 websites were evaluated using a novel instrument, JHU‐SALT, that includes 14 questions on topics related to salt reduction. The questions are grouped into three domains (“information,” “guidance,” and “accuracy”). For each question, websites were scored using a 3‐step ordinal scale (“topic not addressed,” “topic somewhat addressed,” or “topic addressed adequately”). Only three of 14 JHU‐SALT questions were addressed adequately by a majority of websites. Many websites provided information on the adverse health effects of a high sodium diet (74%, n = 51) or mentioned intake recommendations (64%, n = 44). Information on fundamental concepts was largely missing. The majority of websites (80%, n = 55) provided information on lifestyle strategies to reduce blood pressure, but most did not provide guidance to help implement those strategies. While missing information was common, misinformation was uncommon. The DISCERN questionnaire was utilized as well. Consumers seeking information and guidance on dietary sodium reduction will find that most available websites provide accurate but limited information, and insufficient guidance on how to lower sodium intake. Websites that provide both relevant information and guidance are needed to help consumers effectively reduce dietary sodium.
Hypertension differentially impacts cognition in men and women in early midlife
Authors: Shields Hannah L. , Konishi Kyoko , Aroner Sarah , Aizley Harlyn , Remington Anne , Lee Hang , Buka Stephen , Goldstein Jill M. 
Published: September 2022

AbstractThe current study aimed to understand how sex differences in the timing of hypertension onset contribute to early midlife risk for cognitive decline that may differ by sex and whether sex‐dependent advantages in normotensive populations are influenced by the presence of hypertension. One hundred and ninety‐five adults aged 45–55 from the New England Family Study underwent neuropsychological testing to assess attention, executive function, and memory. Physician‐diagnosed hypertension status was self‐reported via questionnaire. Mid‐adulthood hypertension was associated with worse performance on measures of attention and memory, but the cognitive domains impacted varied by sex. Hypertension was associated with only attention in men, whereas in women it was associated with attention and associative and working memory. Sex differences in midlife cognitive performance found in normotensive adults were attenuated in those with hypertension. Our results underscore the importance of accounting for sex when assessing the impact of hypertension on midlife cognition that could be indicative of later decline and risk for cognitive impairment and dementia, given hypertension is an independent risk factor.