bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying research priorities for road safety in Nepal: a Delphi study
Authors: Pant Puspa Raj , Rana Pranita , Pradhan Kriti , Joshi Sunil Kumar , Mytton Julie 
Published: April 2022

ObjectiveTo identify and prioritise the research needed to help Nepali agencies develop an improved road safety system.DesignDelphi study.SettingNepal.ParticipantsStakeholders from government institutions, academia, engineering, healthcare and civil society were interviewed to identify knowledge gaps and research questions. Participants then completed two rounds of ranking and a workshop.ResultsA total of 93 participants took part in interviews and two rounds of ranking. Participants were grouped with others sharing expertise relating to each of the five WHO ‘pillars’ of road safety: (1) road safety management; (2) safer roads; (3) safer vehicles; (4) safer road users and (5) effective postcrash response. Interviews yielded 1019 research suggestions across the five pillars. Two rounds of ranking within expert groups yielded consensus on the important questions for each pillar. A workshop involving all participants then led to the selection of 6 questions considered the most urgent: (1) How can implementing agencies be made more accountable? (2) How should different types of roads, and roads in different geographical locations, be designed to make them safer for all road users? (3) What vehicle fitness factors lead to road traffic crashes? (4) How can the driver licensing system be improved to ensure safer drivers? (5) What factors lead to public vehicle crashes and how can they be addressed? and (6) What factors affect emergency response services getting to the patient and then getting them to the right hospital in the best possible time?ConclusionsThe application of the Delphi approach is useful to enable participants representing a range of institutions and expertise to contribute to the identification of road safety research priorities. Outcomes from this study provide Nepali researchers with a greater understanding of the necessary focus for future road safety research.
Comparing opioid types in the persistence of opioid use following surgical admission: a study protocol for a retrospective observational linkage study comparing tapentadol and oxycodone in Australia
Authors: Lam Tina , Biggs Nicholas , Xia Ting , Evans John , Stevens Jennifer , da Gama Mike , Lubman Dan I , Nielsen Suzanne 
Published: April 2022

IntroductionEach year, an estimated two million Australians commence opioids, with 50 000 developing longer-term (persistent) opioid use. An estimated 3%–10% of opioid-naïve patients prescribed opioids following surgery develop persistent opioid use. This study will compare rates of persistent opioid use between two commonly used postoperative opioids, oxycodone and tapentadol, to understand if initial postoperative opioid type is important in determining longer-term outcomes.Methods and analysisA retrospective data linkage study that analyses administrative data from hospital and community pharmacies. Data will be obtained from at least four pharmacies that service large hospitals with comparable supplies of oxycodone and tapentadol. The study will include at least 6000 patients who have been dispensed a supply of oxycodone or tapentadol to take home following their discharge from a surgical ward. The primary outcome measure will be persistent opioid use at 3 months postdischarge for opioid naïve people who receive either immediate release tapentadol or immediate release oxycodone. Hierarchical logistic regression models will be used to predict persistent opioid use, controlling for covariates including comorbidities.Ethics and disseminationEthics approval has been obtained through the Monash University Human Research Ethics Committee (29977). We will present project findings in a peer-reviewed journal article, in accordance with the REporting of studies Conducted using Observational Routinely-collected health Data statement.
‘That time of the month’ … for the biggest event of your career! Perception of menstrual cycle on performance of Australian athletes training for the 2020 Olympic and Paralympic Games
Authors: McNamara Alice , Harris Rachel , Minahan Clare 
Published: April 2022

ObjectiveThis study explored the perceived effect of the menstrual cycle (MC) on the performance of Australian female athletes, preparing for the Tokyo Olympic and/or Paralympic Games.Methods195 female athletes, nominated by 24 National Sporting Organisations as preparing for the Tokyo Olympic and/or Paralympic Games, completed an online questionnaire (‘MCq perceptions’). The MCq perceptions investigated menstrual symptoms, hormonal contraceptive (HC) use and a preferred competition window within the MC.ResultsTwo-thirds (65.6%) athletes reported that their MC affected their performance; in training (65.6%) compared with competition (58.0%).Aesthetic-sport athletes were most likely to perceive their performance to be affected by their MC (RR=1.40) compared with endurance (RR=0.88) and strength-sport (RR=1.04) athletes. Athletes experiencing three or more symptoms were twice as likely to identify as affected. Athletes who reported pain (RR=1.89) or the use of analgesia (RR=1.45) were more likely to identify as affected by their MC.A preferred competition window was identified by athletes as ‘just after your period’ (41.5%). For athletes not using HC, this window was identified by 53.7%.ConclusionIn Australia, elite-female athletes perceive their MC to affect their performance, and many have a preferred performance window. Performance-focused strategies should be created for ‘affected’ athletes, aiming to provide these athletes with education, and where appropriate, control over predictability, timing and symptoms of their MC.
Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits
Authors: Brenton J Nicholas , Lehner-Gulotta Diana , Woolbright Emma , Banwell Brenda , Bergqvist A G Christina , Chen Shanshan , Coleman Rachael , Conaway Mark , Goldman Myla D 
Published: April 2022

BackgroundDietary changes impact human physiology and immune function and have potential as therapeutic strategies.ObjectiveAssess the tolerability of a ketogenic diet (KD) in patients with relapsing multiple sclerosis (MS) and define the impact on laboratory and clinical outcome metrics.MethodsSixty-five subjects with relapsing MS enrolled into a 6-month prospective, intention-to-treat KD intervention. Adherence was monitored with daily urine ketone testing. At baseline, fatigue, depression and quality of life (QoL) scores were obtained in addition to fasting adipokines and MS-related clinical outcome metrics. Baseline metrics were repeated at 3 and/or 6 months on-diet.ResultsEighty-three percent of participants adhered to the KD for the study duration. Subjects exhibited significant reductions in fat mass and showed a nearly 50% decline in self-reported fatigue and depression scores. MS QoL physical health (67±16 vs 79±12, p<0.001) and mental health (71±17 vs 82±11, p<0.001) composite scores increased on-diet. Significant improvements were noted in Expanded Disability Status Scale scores (2.3±0.9 vs 1.9±1.1, p<0.001), 6-minute walk (1631±302 vs 1733±330 ft, p<0.001) and Nine-Hole Peg Test (21.5±3.6 vs 20.3±3.7 s, p<0.001). Serum leptin was lower (25.5±15.7 vs 14.0±11.7 ng/mL, p<0.001) and adiponectin was higher (11.4±7.8 vs 13.5±8.4 µg/mL, p=0.002) on the KD.ConclusionKDs are safe and tolerable over a 6-month study period and yield improvements in body composition, fatigue, depression, QoL, neurological disability and adipose-related inflammation in persons living with relapsing MS.Trial registration informationRegistered on ClinicalTrials.gov under registration numberNCT03718247, posted on 24 October 2018. First patient enrolment date: 1 November 2018. Link:https://clinicaltrials.gov/ct2/show/NCT03718247?term=NCT03718247&draw=2&rank=1.
Risk factors for severe lower extremity ischemia following venoarterial extracorporeal membrane oxygenation: an analysis using a nationwide inpatient database
Authors: Honda Akira , Michihata Nobuaki , Iizuka Yoichi , Uda Kazuaki , Morita Kojiro , Mieda Tokue , Takasawa Eiji , Ishiwata Sho , Tajika Tsuyoshi , Matsui Hiroki , Fushimi Kiyohide , Yasunaga Hideo , Chikuda Hirotaka 
Published: April 2022

ObjectivesVenoarterial extracorporeal membrane oxygenation is increasingly being used as a life-saving modality in critically ill patients. Despite its necessity, severe lower extremity ischemia associated with venoarterial extracorporeal membrane oxygenation remains a potentially devastating complication. We aimed to investigate the incidence and risk factors for severe lower extremity ischemia requiring fasciotomy or amputation following venoarterial extracorporeal membrane oxygenation.MethodsAll patients who received venoarterial extracorporeal membrane oxygenation during hospitalization were identified in a Japanese national inpatient database from July 1, 2010 to March 31, 2018. The primary outcome was occurrence of severe lower extremity ischemia that required fasciotomy or amputation. We used cause-specific proportional hazard models to examine the associations between potential risk factors and outcomes. We also performed a competing-risk analysis to estimate the cause-specific HR for severe lower extremity ischemia using a multivariable competing-risk Cox proportional hazard model with adjustment for potential risk factors.ResultsA total of 29 231 patients who underwent venoarterial extracorporeal membrane oxygenation during hospitalization were identified. Of these, 98 patients (0.3%) had lower extremity ischemia requiring fasciotomy or amputation. The young group (≤18 years) had a significantly higher proportion of severe lower extremity ischemia cases than the adult (19–59 years) and elderly (≥60 years) groups (1.4%, 0.5%, and 0.2%, respectively; p<0.001). In a multivariable competing-risk Cox proportional hazards regression model, younger age (HR 3.06; 95% CI 1.33 to 7.02; p<0.008) and consciousness disturbance on admission (HR 2.53; 95% CI 1.60 to 3.99; p<0.001) were significantly associated with higher likelihood of severe lower extremity ischemia.ConclusionIn this study using a nationwide database, younger age and consciousness disturbance on admission were associated with higher risk of severe lower extremity ischemia following venoarterial extracorporeal membrane oxygenation.Level of evidenceLevel Ⅲ—prognostic and epidemiological.
Factors affecting river turbidity in a degrading permafrost environment: the Tasiapik River, Umiujaq (Nunavik)
Authors: Manseau Frédéric , Bhiry Najat , Molson John , Cloutier Danielle 
Published: April 2022

This study focuses on spatiotemporal changes in water turbidity in relation to permafrost to document the impact of meteorological conditions and water flow on hydro-sedimentary processes in northern regions. Starting in June of 2019, water turbidity data were collected at six sites along the Tasiapik River (Nunavik). A statistical analysis was completed based on records of water turbidity, precipitation, water flow, and air temperature. Our results show a significant correlation between air temperatures and turbidity, with a correlation of up to r = 0.59. These correlations depend on the location of the site along the river and the time of the study period (June–October 2019). The flow rate was the primary factor that caused variations in the turbidity of the Tasiapik River. Our results showed that following an increase in flow rate, there was an almost simultaneous increase in turbidity due to erosion of the banks. The duration and intensity of precipitation events are also important factors affecting the process of sediment transport. Even though meteorological conditions play an important role in turbidity variation, other characteristics of the site such as the topography and the existence of thermokarst lakes are additional factors that influence the dynamics of sediment transport in the Tasiapik River.
Q-Balls formation and the production of gravitational waves with non-minimal gravitational coupling
Authors: Wang Fei , Wang Rui 
Published: April 2022

AbstractWe propose to introduce non-minimal couplings of Affleck–Dine (AD) field to gravity by adding the coupling of AD field to the Ricci scalar curvature. As the Jordan frame supergravity always predict $$|\Phi |^2 {{\mathcal {R}}}/6$$

|
Φ
|

2

R
/
6

type coupling for scalars with canonical kinetic terms, we propose a way to realize the required $$c_0|\Phi |^2 {{\mathcal {R}}}$$

c
0

|
Φ
|

2

R

-type couplings with generic $$c_0$$

c
0

for canonical complex scalar fields after SUSY breaking. The impacts of such non-minimal gravitational couplings for AD field is shown, especially on the Q-balls formation and the associated gravitational wave (GW) productions. New form of scalar potential for AD field in the Einstein frame is obtained. By numerical simulations, we find that, with non-minimal gravitational coupling to AD field, Q-balls can successfully form even with the choice of non-negative K parameter for $$\xi >0$$

ξ
>
0

. The associated GW productions as well as their dependences on the $$\xi $$
ξ
parameter are also discussed.
NodeSim: node similarity based network embedding for diverse link prediction
Authors: Saxena Akrati , Fletcher George , Pechenizkiy Mykola 
Published: April 2022

AbstractIn real-world complex networks, understanding the dynamics of their evolution has been of great interest to the scientific community. Predicting non-existent but probable links is an essential task of social network analysis as the addition or removal of the links over time leads to the network evolution. In a network, links can be categorized as intra-community links if both end nodes of the link belong to the same community, otherwise inter-community links. The existing link-prediction methods have mainly focused on achieving high accuracy for intra-community link prediction. In this work, we propose a network embedding method, called NodeSim, which captures both similarities between the nodes and the community structure while learning the low-dimensional representation of the network. The embedding is learned using the proposed NodeSim random walk, which efficiently explores the diverse neighborhood while keeping the more similar nodes closer in the context of the node. We verify the efficacy of the proposed embedding method over state-of-the-art methods using diverse link prediction. We propose a machine learning model for link prediction that considers both the nodes’ embedding and their community information to predict the link between two given nodes. Extensive experimental results on several real-world networks demonstrate the effectiveness of the proposed method for both inter and intra-community link prediction.
Two-wavelet theory and two-wavelet localization operators on the q-Dunkl harmonic analysis
Authors: Tyr Othman , Daher Radouan 
Published: April 2022

In this paper, using the [Formula: see text]-Dunkl harmonic analysis introduced in Bettaibi and Bettaieb [q-Analog of the Dunkl transform on the real line, Tamsui Oxf. J. Math. Sci. 25(2) (2007) 117–205] and motivated by Wong’s approach [M. W. Wong, Wavelet Transforms and Localization Operators, Vol. 136 (Springer Science & Business Media, Berlin, 2002)], we first define and study the [Formula: see text]-wavelets, the continuous [Formula: see text]-wavelet transforms. Next, we introduce the two-wavelet localization operators, the Schatten–von Neumann properties of these localization operators are established, and for trace class localization operators, the traces and the trace class norm inequalities are presented.
Translating “Big Data” in Oncology for Clinical Benefit: Progress or Paralysis
Authors: Barker Anna D. , Lee Jerry S.H. 
Published: April 2022

Abstract
The molecular characterization of cancer through genomics, data from multiomics technologies, molecular-driven clinical trials, and internet-enabled devices capturing patient context and real-world data are creating an unprecedented big data revolution across the cancer research-care continuum. While big data has translated to benefit for some patients, it has also created new problems. Our intent in this brief communication is to explore some examples of progress and key challenges that remain. The problems are not intractable, but success will require rethinking and rebuilding an information and evidence-based learning system that moves beyond paralysis to shape a better future for patients with cancer.
Heterarchy
Authors: Urciuoli Emiliano R. 
Published: April 2022

Abstract
Transferred from neurophysiology and cybernetics to the humanities and the social sciences by settlement archeologist Carole L. Crumley, the notion of heterarchy, in particular, and heterarchical thinking, in general, have contributed to changing the way in which power structures other than hierarchies are seen as patterns for order in complex societies. The very idea of social complexity has been transformed by challenging the conflation of order with ranked order. New models for cultural evolution also appear when hierarchy is uncoupled from complexity and heterarchical relations are observable all the way to the historical development of a society as well as at different levels of a system. Opening the special issue, this article aims to introduce the concept of heterarchy to specialists of religion by showing benefits and drawbacks of its application to the study of urban religion. Eventually, the purpose of the selected articles is to leverage this promising category to explore and deepen understanding of the millennia-long coevolution of religion and urbanity.
Religious Gentrification as Heterarchies of Urban Planning
Authors: Luz Nimrod 
Published: April 2022

Abstract
This article explores the ways in which religion(s) and religious groups are increasingly contributing to changes in the politics of planning of cities and challenge the hierarchical modern planning order. Following the notion of heterarchy as suggesting a diversity of relationships among elements in a system, the argument is made that the religious-cum-ethnic component is becoming part of an urban habitus that influences and redefines modern urban planning. Taking the case of a recently developed gentrified religious Jewish neighborhood in Acre, a multi-ethnic and multi-religious town in northern Israel, the article follows the ways in which urban planning is being shaped by three interrelated processes: the production of space driven by forms of capitalism intertwined with local heterarchical projects of space and power; a set of social struggles over urban space; and the framing of religious and ethnic urban identity.
Going Unseen in the Medieval and Early Modern Jewish Magical Tradition
Authors: Bellusci Alessia 
Published: April 2022

Abstract
After a brief methodological introduction, the article reconstructs invisibility magic, its uses and rationale in medieval and early modern Jewish culture, based on a rich selection of manuscript texts, many of which remain unpublished. In contrast to other treatments of invisibility magic, it argues that in this specific cultural context the desire of going unseen was often motivated by contingent purposes such as protection on the road and self-defense. Some techniques of Jewish invisibility magic exhibit a marked Jewish character, some were inspired by the observation of nature, others were modulated on popular motifs shared cross-culturally. This study demonstrates that, regardless to their nature, most of these techniques were reworked according to a Jewish taste, proving that invisibility magic was not an extravagant import from foreign traditions, but an integral part of a magical culture shared by many Jews during the Middle Ages and early modern period.
New Culture Turns One Hundred: A Centennial Reflection on the May Fourth and New Culture Movement in Singapore
Authors: Kenley David 
Published: April 2022

Abstract
Centennial commemorations of the May Fourth Movement in Singapore demonstrate how practices of remembrance reinforce but also transcend national and cultural boundaries. Throughout 2019, Singaporeans reflected on the iconoclastic, anti-imperialist, and pro-democracy elements of May Fourth while simultaneously challenging public memories as observed in China. As such, these commemorations shed important light on memory studies, postcoloniality, and Singapore Chinese identity.
Chinese-Medicine Doctors Healing Australians: On the Frontline of Healthcare from the Colonial Period to the Twenty-First Century
Authors: Flowers James 
Published: April 2022

Abstract
This article traces Chinese-medicine doctors as an occupational group that played a key role in colonial Australian healthcare. The current narrative of recent history mostly credits prc migrants, beginning from the 1990s and the prc state in the 2000s, with the field’s achievement of professional registration. This established view is shortsighted and distorts the past. Rather, Chinese medicine traveled to Australia with Chinese migrants since the mid-nineteenth century; they brought with them sophisticated business acumen along with medical expertise, as seen in commercialized raw and patent medicines brought from a highly developed pharmaceutical industry in mainland China and Hong Kong. They were competitive with Western-trained doctors, as seen in court documents as well as in newspaper advertisements of the time, and established their status through lineage connections and acupuncture associations before any influence from the prc.
Suprachoroidal injection of triamcinolone acetonide using a custom-made needle to treat diabetic macular edema post pars plana vitrectomy: a case series
Authors: Marashi Ameen , Zazo Aya 
Published: April 2022

Objective Diabetic macular edema (DME), the most common cause of diabetes-related visual impairment, may occur following pars plana vitrectomy (PPV) to manage proliferative diabetic retinopathy complications. This retrospective single-centre case series evaluated the efficacy and safety of injecting 4 mg/0.1 ml triamcinolone into the suprachoroidal space using a custom-made needle to treat DME post PPV. Methods Data regarding central macular thickness (CMT) using spectral domain-optical coherence tomography and best-corrected visual acuity (by Snellen chart) at baseline (pre-injection), and at 1, 4, and 8 weeks following injection were analysed, along with intraocular pressure (IOP), cataract progression, and ocular safety. Results Eleven eyes in 10 patients received 11 suprachoroidal injections. Vision improvement was noted (0.75 log minimum angle of resolution (MAR) at baseline to 0.40 log MAR after treatment). CMT reduced significantly from 456.45 ± 113.42 μm at baseline to 247.63 ± 53.40 μm at 8 weeks following injection. No rise in IOP, or cataract development in the single treated phakic eye, was observed during 8 weeks of follow-up. Conclusion Suprachoroidal injection of triamcinolone using a custom-made needle to treat DME post PPV shows promising results with acceptable safety outcomes. Large clinical trials with longer follow-up are needed to evaluate this treatment option for countries with limited health-care resources.