bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Promyelocytic Leukemia Masquerading as Sero-negative Polyarthritis: Case Report
Authors: Chauhan Priyanka , Gupta Anshul , Panambur Chandni Bhandary , Chandra Dinesh , Kashyap Rajesh 
Published: September 2022

AbstractMusculoskeletal manifestations as the sole presentation in acute leukemia is rare in adults. Acute promyelocytic leukemia (APML) is a subtype of acute myeloid leukemia (AML) with reported incidence of 10 to 15% of total AML cases. APML presenting as polyarticular arthritis has never been reported in the literature. We present an interesting case of 20-year-old male patient who manifested with polyarticular arthritis mainly of small joints as the initial presentation, followed by pancytopenia and eventually was diagnosed as a case of APML on bone marrow morphology and molecular analysis for PML-RARα transcript. He was successfully treated with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO). Arthritis also resolved with complete remission of APML. Arthritis in a case with pancytopenia should promptly be evaluated prior to treatment with steroids and anti-metabolites. Arthritis can be a presenting manifestation of APML and responds to prompt management of leukemia as in other cases of leukemic arthritis.
A Promising Future for Hands-On At-Home Training in Pediatric Surgery
Authors: Joosten Maja , Wijnen Rene , de Blaauw Ivo , Botden Sanne M. B. I. 
Published: September 2022

Abstract
Introduction Sufficient training is needed to acquire and retain the procedural skills needed for the surgical correction of congenital anatomical malformations. This study aims to assess the opinions of trainees and pediatric surgeons on the use of simulation-based continued at-home training, which can help to acquire these skills.
Methods This study consisted of two parts. First, an international survey among trainees and pediatric surgeons assessed their opinions on simulation-based at-home training for pediatric surgical procedures (5-point Likert scale). Second, participants of pediatric colorectal courses were instructed to practice the posterior sagittal anorectoplasty procedure at-home on a simulation model and, subsequently, complete a questionnaire regarding their opinions on continuous at-home training (5-point Likert scale).
Results A total of 163 participants (83% pediatric surgeons) completed the international survey (response rate 43%). Overall, participants considered the training useful for both laparoscopic (mean 4.7) and open procedures (mean 4.2) and agreed that it may be used at home after a hands-on course (mean 4.3).Twenty participants completed the questionnaire on continued training (response rate 36%). All agreed that at-home training was of added value (mean 4.5) and that the skills were transferable to the clinical setting (mean 4.3). At-home training was regarded a suitable exercise after a hands-on workshop (mean 4.3), but less so without a workshop (mean 3.7, p=0.017).
Conclusion Participating trainees and pediatric surgeons were of the opinion that simulation models and at-home training have added value. This implies that simulation-based training may be used more often in pediatric surgical training.
The Utility of NATEM Assay in Predicting Bleeding Risk in Critically Ill Neonates
Authors: Sokou Rozeta , Georgiadou Petroula , Tsantes Andreas G. , Parastatidou Stavroula , Konstantinidi Aikaterini , Ioakeimidis Georgios , Makrogianni Athanasia , Theodoraki Martha , Kokoris Styliani , Iacovidou Nicoletta , Kriebardis Anastasios G. , Piovani Daniele , Bonovas Stefanos , Tsantes Argirios E. 
Published: September 2022

AbstractWe aimed to investigate the hemostatic status of diseased neonates using nonactivated rotational thromboelastometry (ROTEM) assay (NATEM) assay and, in addition, to evaluate the discriminative power of NATEM parameters in predicting the risk of bleeding in critically ill neonates and compare it to that of EXTEM (extrinsically activated ROTEM) parameters. This cohort study included 158 consecutive, critically ill neonates with presumed sepsis, perinatal hypoxia, or respiratory distress syndrome. The EXTEM and NATEM assays were performed on the first day of disease onset. The neonatal bleeding assessment tool was used to record and assess clinical bleeding events on the day of ROTEM analysis. Several EXTEM and NATEM ROTEM parameters differed between neonates with and without clinical bleeding events, indicating a hypo-coagulable state in neonates with clinical bleeding. NATEM parameters had comparable predictive performance for clinical bleeding events with EXTEM parameters for clotting time, clot formation time (CFT), A10 (clot amplitude at 10minutes), maximum clot firmness, lysis index at 60minutes, and maximum clot elasticity (p>0.05). However, NATEM A20, A30, and α angle demonstrated better predictive ability than EXTEM A20, A30, and α angle, respectively (p<0.05). A NATEM CFT value ≥147seconds presented 95.2% sensitivity (95% confidence interval [CI]: 76.1–99.8%) and 65.6% specificity (95% CI: 57.1–73.5%) to detect neonates with clinical bleeding, while a NATEM A10 value ≤42mm had 80.8% sensitivity (95% CI: 71.8–85.9%) and 76.0% specificity (95% CI: 52.8–91.7%) to detect neonates with clinical bleeding events. The NATEM assay has shown remarkable sensitivity in predicting bleeding in critically ill neonates, exceeding EXTEM performance in some selected parameters. The incorporation of NATEM test parameters in predictive models for neonatal hemorrhage seems promising.
Thromboelastography-Guided Therapy Enhances Patient Blood Management in Cirrhotic Patients: A Meta-analysis Based on Randomized Controlled Trials
Authors: Hartmann Jan , Dias Joao D. , Pivalizza Evan G. , Garcia-Tsao Guadalupe 
Published: September 2022

AbstractPatients with cirrhosis often have abnormal hemostasis, with increased risk of hemorrhage and thrombosis. Thromboelastography provides a rapid assessment of the coagulation status and can guide product transfusions in adult patients with cirrhosis. This study aimed to determine whether the use of thromboelastography in adult patients with cirrhosis decreases blood product use and impacts adverse events or mortality compared with standard practice. A registered (PROSPERO CRD42020192458) systematic review and meta-analysis was conducted for randomized controlled trials (RCTs) comparing thromboelastography-guided hemostatic management versus standard practice (control). Co-primary outcomes were the number of transfused platelet units and fresh frozen plasma (FFP) units. Secondary outcomes were mortality, adverse events, utilization of individual blood products, blood loss or excessive bleeding events, hospital/intensive care unit stay, and liver transplant/intervention outcomes. The search identified 260 articles, with five RCTs included in the meta-analysis. Platelet use was five times lower with thromboelastography versus the control, with a relative risk of 0.17 (95% confidence interval [CI]: [0.03–0.90]; p = 0.04), but FFP use did not differ significantly. Thromboelastography was associated with less blood product (p < 0.001), FFP + platelets (p < 0.001), and cryoprecipitate (p < 0.001) use. No differences were reported in bleeding rates or longer term mortality between groups, with the thromboelastography group having lower mortality at 7 days versus the control (relative risk [95% CI] = 0.52 [0.30–0.91]; p = 0.02). Thromboelastography-guided therapy in patients with cirrhosis enhances patient blood management by reducing use of blood products without increasing complications.
Pediatric Acute Myeloid Leukemia in India: A Systematic Review
Authors: Srinivasan Shyam , Gollamudi Venkata Rama Mohan , Dhariwal Nidhi 
Published: September 2022

AbstractBackground Lower-middle-income countries face unique problems in the management of pediatric acute myeloid leukemia (AML) due to which the outcomes have not kept pace with developed nations. In India, data on childhood AML is sparsely available, thus making a true assessment of disease trends difficult. The current systematic review was undertaken to assess the outcomes of childhood AML from published literature from India over a period of 10 years (2011–2021).Materials and Methods A systematic search of MEDLINE, Google Scholar, and SCOPUS was performed as per preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement from January 1, 2011 to December 31, 2021. In addition, International Society of Pediatric Oncology (SIOP) conference abstracts were also screened for relevant studies on AML from India. This study was registered in PROSPERO (ID42021273218).Results A total of 1,210 patients from 19 studies were included. Standard 3 + 7 and MRC AML based regimens were commonly adopted regimens for induction. Remission rates varied between 56 and 95%. Overall treatment-related mortality across studies was 23.2% (95% confidence interval [CI]: 10.3–35.9%). The mean incidence of treatment abandonment was 19.3% ( 95% CI: 10.9–27.5%). Event-free survival and overall survival were in the range of 28 to 55% and 15 to 66%, respectively. Hematopoietic stem cell transplantation was performed only on a small subset of patients.Conclusion  Outcomes of pediatric AML in India continue to be suboptimal with high treatment abandonment and toxic deaths. Ensuring uniform access to therapy and supportive care along with a robust social support system would improve outcomes of childhood AML in India.
Effect of Patellofemoral Arthroplasty on Patellar Height in Patients with Patellofemoral Osteoarthritis
Authors: Lee Hannah , Fletcher Connor , Hartwell Matthew , Strickland Sabrina M. 
Published: September 2022

AbstractOsteoarthritis (OA) in the knee is common, painful, and may be uni- or multicompartmental. The compartment affected by arthritis may be due to trauma, malalignment (varus or valgus), or in the case of patellofemoral OA, patella alta. Patellofemoral arthroplasty (PFA) is an effective partial knee replacement surgery for patellofemoral OA. We hypothesized that PFA can decrease patellar height. In addition, we predicted better outcomes for patients with patella alta before PFA and those whose patellar heights decreased after PFA. This is a retrospective cohort study of PFA patients from 2012 to 2020. Before and after PFA, we measured patellar heights on X-ray images and collected patient-reported outcome measures (PROMs) (International Knee Documentation Committee score, Kujala Anterior Knee Pain Score, and Veterans RAND 12-Item Health Survey for mental and physical health). Statistical analyses assessed PROMs and compared outcomes based on pre- and postoperative patella height. Of 133 knees, 73% presented with patella alta and 61% had patellar heights that decreased after PFA. Compared with patients who did not present with patella alta, patients with patella alta reported similar outcomes with respect to knee function, pain, and general physical and mental health. Compared with patients whose patellar heights decreased after PFA, patients whose knees did not decrease in height reported greater improvements in pain and function. Our findings suggest that patella alta is commonly found in patients with patellofemoral OA and that PFA can decrease patellar height. Future studies are needed to assess whether patellofemoral OA patients with greater degrees of patella alta would benefit from staged or concurrent tibial tubercle distalization.
Race/Ethnicity and Perception of Care: Does Patient–Provider Concordance Matter?
Authors: Adams Constants , Francone Nicolás , Chen Liqi , Yee Lynn M. , Horvath Madeleine , Premkumar Ashish 
Published: September 2022

Objective We determine whether racial concordance between postpartum patients and obstetric providers (dyads) impacts the perception of quality of care among people undergoing intrapartum obstetrical procedures.
Study Design This is a prospective cohort study of postpartum people who underwent operative vaginal or cesarean deliveries in the second stage of labor. Participants were asked to identify the race of their primary provider and complete the Interpersonal Processes of Care (IPC) survey, which assesses communication, patient-centered decision-making, and interpersonal style. The association of participant-identified patient–provider racial concordance with IPC scores was determined. The primary outcome was the IPC subdomain related to discrimination, and secondary outcomes included other IPC subdomains and IPC results by participant racial identity (Black, LatinX vs. White). Sociodemographic and biomedical data were extracted from the medical record. Bivariable analyses were performed.
Results Of 168 patients who were approached, 107 (63.6%) agreed to participate and 87 (81.3%) completed the survey. The majority (n=49) identified a racially discordant provider. Participants in racially concordant dyads were more likely to be older, White, use English as a primary language, complete a higher degree of education, and have a higher household income when compared with racially discordant dyads. Intrapartum outcomes were not significantly different between groups. Median IPC subtest scores were not significantly different between groups or between racial/ethnic identities.
Conclusion There were no significant differences in perceptions of IPC between racially concordant versus discordant dyads. However, there is an ongoing need to further clarify measures of quality of care in high-acuity obstetrical situations to remediate ongoing racial and ethnic disparities in adverse health outcomes.
Key Points
Assessment of Psychological Distress Among Indian Adolescents and Young Adults with Solid Cancer Using the National Comprehensive Cancer Network Distress Thermometer
Authors: Shrivastava Shiv Prasad , Elhence Aditya , Jinwala Prutha , Bansal Shashank , Chitalkar Prakash , Bhatnagar Shweta , Patidar Rajesh , Asati Vikas , Reddy Pradeep Kumar 
Published: September 2022

Purpose The incidence of cancer has increased in India with a visible impact on the young population (aged 15–39 years). The present study aims to evaluate psychological distress among Indian adolescents and young adults (AYAs) with solid cancer using the National Comprehensive Cancer Network (NCCN) distress thermometer.
Methods The demographic and clinical characteristics of AYAs patients (age 15–39 years) with cancer were recorded. Assessment of psychological distress of patients using the NCCN distress thermometer was performed at three time points over a period of 3 months. Distress thermometer scale and a self-administered questionnaire in English and Hindi languages was handed over to participants at three time points: at treatment commencement (T1), at 1 month, and 3 months (T2 and T3, respectively) into therapy.
Results Of the 259 patients, 63% were women and 37% men; the median age was 34 years. In total, 71 (27%) were ≤ 24 years old and 188 (73%) were>24 years old. Bone sarcoma (39%) was common cancer in AYA patients aged ≤ 24 years and breast cancer (21%) in >24 years of age. The distress scores in both the groups were the highest at diagnosis (T1) followed by that measured at 1 (T2) and 3 months (T3) after diagnosis. The distress score in the age ≤ 24 years was the highest (6.7) at T1, followed by those measured at T2 (2.6) and T3 (1.1) and among age>24 years was the highest (6.6) at T1, followed by those measured at T2 (2.6) and T3 (1.2). Among AYA patients>24 years old, worry, nervousness, sadness, transportation, and sleep were the top five identified problems and in ≤ 24 years old, the top identified problems were worry, financial support, sleep, nervousness, and sadness.
Conclusion Adolescents and young adults experience some level of distress associated with the cancer diagnosis, effects of the disease, treatment regardless of the stage and various transitions throughout the trajectory of the disease. The distress thermometer is an easy and useful tool for the assessment of psychological distress in AYA cancers. Early identification of distress burden with the distress thermometer leads to effective interventions in patients with cancer which could improve outcomes including survival in AYAs with cancer in India.
Validity and reliability of a questionnaire developed to explore quality assurance components for teaching and learning in vocational and technical education
Authors: Wafudu Satumari John , Kamin Yusri Bin , Marcel Daniel 
Published: September 2022

AbstractMost vocational and technical education (VTE) educational systems invest in quality assurance for teaching and learning to improve the skills of the workforce that would contribute to socio-economic development. Quality assurance provides confidence in educational services to meet the quality desires of teaching and learning settings. Yet it has been reported that there are challenges in teaching and learning effectiveness due to a lack of technological breakthroughs among students, resulting in an insufficiently skilled workforce. The primary aim of this study is to develop and validate a questionnaire for quality assurance for teaching and learning in vocational and technical education. The questionnaire was developed based on the data obtained by item generation through an interview with quality managers, administrators, and lecturers and a literature review. The content validity of the quality assurance for teaching and learning (QATL) questionnaire was validated using expert judgment. The principal component analysis (PCA) and orthogonal varimax techniques examined the structures and validity of the quality components. After exploratory factor analysis on the quality components under input, process, and output domains, the input quality factors explained 78.81% of the cumulative variance, the process quality factors explained 72.679% of the cumulative variance, and the output quality factors explained 75.027% of the cumulative variance. The analysis used Cronbach’s alpha to test the internal consistency reliability, and the alpha values ranged from 0.835 to 0.963, indicating very high reliability. Present findings suggest that the QATL is a valid and reliable instrument for assessing quality components of quality assurance for teaching and learning in vocational and technical education. These quality components enable optimal VTE objective achievement if implemented in teaching and learning.
How transient effects can change the inferred plasma temperatures when using K-shell sulfur line ratios in a time dependent iron sulfide plasma
Authors: Rilloraza Francisco , Martin Madison E. , London Richard A. , Nilsen Joseph 
Published: September 2022

This paper describes how the steady state atomic kinetics approximation can underestimate the electron temperature determined from K-shell lines in ps-time-scale transient plasmas. In particular, we model the temperature determination of solid FeS targets used in opacity experiments at the Orion laser facility from the ratio of sulfur He-α to Ly-α lines. Such experiments use short-pulse lasers to heat a thin microdot of FeS buried in a plastic target to temperatures of more than 1 keV and densities of approximately 1–2 g/cm3. Using atomic kinetics calculations based on a temperature history from a radiation hydrodynamic simulation of the target evolution, the peak temperature inferred from the sulfur line ratios is 1.29 keV at 3.1 ps as compared with the input peak temperature of 1.41 keV at 2.0 ps. There is a time lag of 1.2 ps at the peak, and an overall 0.5 ps time lag in the temporal history of the temperature as the plasma cools over the next 10 ps.
Aggressive banners, dialect-shouting village heads, and their online fame
Authors: Zhou Feifei 
Published: September 2022

Abstract
At the beginning of the Covid-19 outbreak in China, the state quickly declared a nationwide anti-Covid campaign.
This article looks at how the rural space was transformed during this early anti-Covid campaign. Unlike the official state
discourses, rural officials resorted to direct, down-to-earth, and ‘cold-hearted’ messages to persuade the villagers to comply
with the rules. Based on a study of widely circulated banners and videos online, drawing on Linguistic Landscape studies and discourse
analysis, I investigate the discursive strategies employed in rural LL. Moreover, I discuss how the intended/imagined audiences of
these multimodal signing practices are disconnected from the changed rural population. These discrepancies will be further
examined in light of the online subcultural practices of ‘tuwei culture’. I will argue that much-needed discussion of the actual
difficulties that rural officials face is displaced in the online consumption of rural LL.
A sign in the window
Authors: Douglas Gordon C. C. 
Published: September 2022

Abstract
The proliferation of handmade signage, physical installations, and other neighborhood scale visual communication in the months following the outbreak of Covid-19 presented a unique opportunity to consider how new norms of social conduct and community solidarity are established and negotiated in public space. This study examines the cultural and spatial implications of this informal visual communication through street-level photographic analysis conducted over 18 months in communities around the United States, producing a typology of observed phenomena and highlighting differences across time, place, politics, and intentions. In particular, the author illustrates how the signs not only work to negotiate new norms for public conduct during a time of fear, misinformation, and inconsistent guidelines, but in doing so effectively demonstrate what a grassroots community response looks like to this unusual kind of extreme event.
Signs at work
Authors: Modan Gabriella , Wells Katie J. 
Published: September 2022

Abstract
We use a geographically informed notion of landscape and Williams’ (1977) framework structure of feeling to examine ‘closed’, masking, and social distancing signs on businesses in the Washington, DC central-city neighborhood of Adams Morgan. We argue that the semantic content and discursive structure of the Covid signs, together with the in-the-moment feeling of walking down empty streets while a little-understood virus had just started raging, promoted a reconceptualization of labor relations tied to solidarity, public health, and communal responsibility, and making visible the working conditions of low-wage workers. This new structure of feeling opens up a space – however narrow – of political possibility.
Hybrid places
Authors: Tufi Stefania 
Published: September 2022

Abstract
This article is about adaptations to the regimentation of public and private living through the reorganisation of domestic space and time routines a year into changeable Covid-related restrictions. The discussion is based on narratives and audio-visual artefacts generated by participants from 20 UK households through the methodology of photovoice and that articulate domestic-related boundary-making processes and forms of space hybridisation in the ongoing changes caused by the pandemic. In the article, Covid-19 signage is represented by language and other semiotic markings that engender an inside spatial and social semiotics and that stands in a dialogic relationship with the outside spatial and social semiotics as dictated by the pandemic, and where domestic landscapes articulate forms of transmedia code-mixing that invest written words, sounds, and screens.