bluuebunny/crossref_metadata_2025_split huggingface dataset:
In situ deletions reveal regulatory components for expression of an intracellular immune receptor gene and its co‐expressed genes in Arabidopsis
Authors: Yu Huiyun , Yang Leiyun , Li Zhan , Sun Feng , Li Bo , Guo Shengsong , Wang Yong‐Fei , Zhou Tong , Hua Jian 
Published: November 2022

AbstractIntracellular immune receptor nucleotide‐binding leucine‐rich repeats (NLRs) are highly regulated transcriptionally and post‐transcriptionally for balanced plant defence and growth. NLR genes often exist in gene clusters and are usually co‐expressed under various conditions. Despite of intensive studies of regulation of NLR proteins, cis‐acting elements for NLR gene induction, repression or co‐expression are largely unknown due to a larger than usual cis‐region for their expression regulation. Here we used the CRISPR/Cas9 genome editing technology to generate a series of in situ deletions at the endogenous location of a NLR gene SNC1 residing in the RPP5 gene cluster. These deletions that made in the wild type and the SNC1 constitutive expressing autoimmune mutant bon1 revealed both positive and negative cis‐acting elements for SNC1 expression. Two transcription factors that could bind to these elements were found to have an impact on the expression of SNC1. In addition, co‐expression of two genes with SNC1 in the same cluster is found to be mostly dependent on the SNC1 function. Therefore, SNC1 expression is under complex local regulation involving multiple cis elements and SNC1 itself is a critical regulator of gene expression of other NLR genes in the same gene cluster.
ABA‐responsive AREB1/ABI3‐1/ABI5 cascade regulates IAA oxidase gene SlDAO2 to inhibit hypocotyl elongation in tomato
Authors: Lei Lei , Zhang Jing‐Ya , Pu Dan , Liu Bing‐Zhu , Meng Xian‐Min , Shang Qing‐Mao , Duan Yun‐Dan , Zhang Feng , Zhang Meng‐Xia , Dong Chun‐Juan 
Published: November 2022

AbstractHypocotyl elongation is dramatically influenced by environmental factors and phytohormones. Indole‐3‐acetic acid (IAA) plays a prominent role in hypocotyl elongation, whereas abscisic acid (ABA) is regarded as an inhibitor through repressing IAA synthesis and signalling. However, the regulatory role of ABA in local IAA deactivation remains largely uncharacterized. In this study, we confirmed the antagonistic interplay of ABA and IAA during the hypocotyl elongation of tomato (Solanum lycopersicum) seedlings. We identified an IAA oxidase enzyme DIOXYGENASE FOR AUXIN OXIDATION2 (SlDAO2), and its expression was induced by both external and internal ABA signals in tomato hypocotyls. Moreover, the overexpression of SlDAO2 led to a reduced sensitivity to IAA, and the knockout of SlDAO2 alleviated the inhibitory effect of ABA on hypocotyl elongation. Furthermore, an ABA‐responsive regulatory SlAREB1/SlABI3‐1/SlABI5 cascade was identified to act upstream of SlDAO2 and to precisely control its expression. SlAREB1 directly bound to the ABRE present in the SlDAO2 promoter to activate SlDAO2 expression, and SlABI3‐1 enhanced while SlABI5 inhibited the activation ability of SlAREB1 by directly interacting with SlAREB1. Our findings revealed that ABA might induce local IAA oxidation and deactivation via SlDAO2 to modulate IAA homoeostasis and thereby repress hypocotyl elongation in tomato.
Tumor necrosis factor‐α inhibitor‐induced morphea and psoriasiform dermatitis in a pediatric patient with Crohn's disease
Authors: Reinhart Jacob P. , Aird Jenna L. , Stephens Michael C. , Asch Sarah , Orandi Amir B. , Tollefson Megha M. 
Published: November 2022

AbstractTumor necrosis factor‐alpha inhibitor therapy for inflammatory bowel disease may be associated with paradoxical cutaneous adverse events, most commonly psoriasiform eruptions. We present the case of a pediatric female patient with Crohn's disease who developed multiple concurrent cutaneous eruptions while on infliximab treatment, including morphea, psoriasiform dermatitis, and genital lichen sclerosus. Although refractory to skin‐directed treatments, all three conditions resolved upon discontinuation of infliximab, supporting their development as a paradoxical reaction to infliximab therapy.
The IPTA Nashville consensus conference on Post‐Transplant lymphoproliferative disorders after solid organ transplantation in children: II—consensus guidelines for prevention
Authors: Green Michael , Squires James E. , Chinnock Richard E. , Comoli Patrizia , Danziger‐Isakov Lara , Dulek Daniel E. , Esquivel Carlos O. , Höcker Britta , L'Huillier Arnaud G. , Mazariegos George Vincent , Visner Gary A. , Bollard Catherine M. , Dipchand Anne I. , Ferry Judith A. , Gross Thomas G. , Hayashi Robert , Maecker‐Kolhoff Britta , Marks Stephen , Martinez Olivia M. , Metes Diana M. , Michaels Marian G. , Preiksaitis Jutta , Smets Françoise , Swerdlow Stephen H. , Trappe Ralf U. , Wilkinson James D. , Allen Upton , Webber Steven A. , Dharnidharka Vikas R. 
Published: November 2022

AbstractThe International Pediatric Transplant Association (IPTA) convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post‐transplant lymphoproliferative disorder after solid organ transplantation in children. In this report from the Prevention Working Group, we reviewed the existing literature regarding immunoprophylaxis and chemoprophylaxis, and pre‐emptive strategies. While the group made a strong recommendation for pre‐emptive reduction of immunosuppression at the time of EBV DNAemia (low to moderate evidence), no recommendations for use could be made for any prophylactic strategy or alternate pre‐emptive strategy, largely due to insufficient or conflicting evidence. Current gaps and future research priorities are highlighted.
Induction of ovulation using repeated doses of sulpiride, a dopamine antagonist, in ewe lambs
Authors: Kivrak Mehmet Bugra , Aydin Ibrahim 
Published: November 2022

AbstractThis study aimed to test the hypothesis that sulpiride can increase the concentration of circulating gonadotropin that can promote puberty in pre‐pubertal ewe lambs. Here, 12 1–3‐year‐old Merino rams and 60 7–9‐month‐old Merino sheep were included in the study. The sheep were randomly divided into sulpiride (n = 30) and control (n = 30) groups. The sulpiride group was subcutaneously injected with 0.6 mg/kg sulpiride twice daily (morning and evening) for 9 days. During these 9 days, blood samples were taken from the sheep before drug administration and at 4 h after every drug administration. The number of ovulating animals in the sulpiride group was significantly higher than that in the control group (90% vs. 32%). No oestrous signs were observed in either group during ram release. Further, there were no differences in the levels of mean follicle‐stimulating hormone in the two groups based on treatment (p = .2), time (p = .3) or treatment‐by‐time interaction (p = .3). After sulpiride administration, the luteinizing hormone (LH) levels of the sulpiride group rapidly increased and remained stable for a long time, whereas physiological LH fluctuations in the control group remained unchanged. Within‐group changes in terms of LH concentrations were significant for both groups (p < .001), whereas LH pulse frequency was significantly different between the sulpiride group (p = .03). Therefore, it is concluded that sulpiride can be used as a non‐steroidal alternative to stimulate pre‐pubertal ewe lambs and sheep during anoestrus.
Social investments in the knowledge economy: The politics of inclusive, stratified, and targeted reforms across the globe
Authors: Garritzmann Julian L. , Häusermann Silja , Palier Bruno 
Published: November 2022

AbstractAs countries transition from industrial to post‐industrial knowledge economies, education and skills are crucial. Consequently, policy‐makers around the globe have increasingly focused on social investment, that is, policies aiming to create, mobilize, or preserve skills. Yet, countries around the globe have developed social investments to different degrees and in highly different forms. Our goal is twofold: First, we introduce a new typology of social investment policies, distinguishing nine types along two dimensions: three distributive profiles (inclusive, stratified, targeted) and three functions (skill creation, preservation, mobilization). This differentiation allows fine‐grained analyses of the causes and consequences of different kinds of social investments, thus offering a perspective to study the relationship between efficiency and inclusiveness in a way that goes beyond the mere discussion how social investment policies grosso modo affect inequalities (‘equalizing’ versus ‘Matthew Effects’). Second, we theorize on the politics of social investment. We argue that the interaction of policy legacies and socioeconomic factors is the main explanation for which functions of social investment policies are introduced, whereas their distributive profiles are crucially shaped by political coalitions. We illustrate with empirical material from democracies around the globe.
Study on soil cracks in pneumatic subsoiling based on LSTM
Authors: Li Xia , Wang Sichao , Jiang Zhangjun , Li Xinglong , You Birong , Rui Chengjie 
Published: November 2022

AbstractThis paper reports research based on pneumatic subsoiling and the design of a pneumatic subsoiling mechanism to overcome the problems of high resistance and high energy consumption of subsoiling. By analysing soil‐specific resistance, soil disturbance rate and soil bulkiness under different air pressure conditions, it is concluded that pneumatic subsoiling can effectively break the soil plough pan and reduce resistance to subsoiling. In order to analyse the impact of air pressure on subsoiling, in this study, principal component analysis was used to analyse the pneumatic subsoiling disturbance parameters (working air pressure, working depth and working speed), and the test results show that the contribution of air pressure to subsoiling resistance and subsoiling disturbance surface reached 24% and 25%, respectively. An orthogonal test was used to analyse the specific resistance of subsoiling, and its significance coefficient is 0.95. Long short‐term memory neural networks (LSTM) and bidirectional long short‐term memory neural networks Bi‐LSTM. are used to predict the cracks on the disturbed surface of subsoiling. LSTM is a method to predict future occurrence using time series data, which can be used to predict the cracks on the disturbed surface of soil, while Bi‐LSTM network is an innovative computing paradigm, which learns bidirectional long‐term correlation between time step and sequence data, to predict the trend of fissures on the disturbed soil surface. The RSME of LSTM and Bi‐LSTM are 4.80 and 6.55, and their determinative factor R2 is 0.95 and 0.94 respectively, which indicates that LSTM and Bi‐LSTM can effectively predict the cracks of pneumatic subsoiling. By analysing the specific resistance of pneumatic subsoiling, it can be shown that pneumatic subsoiling can reduce subsoiling resistance and expand the disturbance surface of subsoiling so as to achieve the effects of subsoiling, drag reduction and reduction of fuel consumption.
On deducing ethical egoism from psychological egoism
Authors: Tilley John J. 
Published: November 2022

AbstractA familiar question is whether psychological egoism (suitably supplemented with plausible further premises) entails ethical egoism. This paper considers this question, treating it much more thoroughly than do any previous treatments. For instance, it discusses all the most common understandings of ethical and psychological egoism. It further discusses many strategies and arguments relevant to the question addressed. Although this procedure creates complexity, it has value. It forestalls the suspicion, aroused by so many treatments of this subject, that the results stem largely from leaving stones unturned—for instance, from ignoring many natural argumentative strategies and many familiar understandings of the views discussed. The paper's conclusion is that psychological egoism (suitably supplemented …) does not entail ethical egoism.
‘Cute face and quiet … but her look don't match her personality’: Commodifying flesh, shaping labour expectations and domestic workers' treatment in Singapore
Authors: Antona Laura 
Published: November 2022

AbstractWhile it is well established that domestic work has long been commodified, this paper builds on existing literature to show how employment agencies use the production of biodata to simultaneously, and strategically, homogenise and differentiate domestic workers in Singapore as racialised commodities. As such, and building on existing literatures on racialisation, bodily commodification, corporeality and domestic labour, this paper develops the concept of ‘fleshly commodity’ to convey domestic workers' positioning as racialised, captive, fungible and simultaneously homogenised and differentiated corporeal objects. Moreover, this paper will bring attention to the broader implications of the processes by which employment agencies market, fetishize, and then sell domestic workers. It does so by illuminating how recruitment practices shape the labour required/expected of domestic workers, before demonstrating how their living and working conditions and relations are also impacted. Through engagement with ethnographic data, this paper also demonstrates how domestic workers' humanity, personhood and agency continually contest and undo attempts to render them fleshly commodities.
Dancers as diplomats? Quiet diplomacy and post‐conflict geopolitics in the 1990 Cambodian National Dance Company Tour to the UK
Authors: Rogers Amanda 
Published: November 2022

AbstractThis paper examines the relationship between performance and diplomacy during the 1990 Cambodian National Dance Company Tour to the UK. The tour stemmed from Oxfam UK's Kampuchea Campaign, which attempted to restore bilateral aid to the State of Cambodia by pushing for international recognition and a brokered peace settlement. Contributing to geographical work on diplomacy, the paper examines the different agents involved in the tour and their response to the dancers as diplomatic actors, examining the different types of performance in operation and their relationship to diplomacy. Dance was often oriented towards geopolitical ends, but there were also moments when dancers used their artistic performances to open up new modes of subjectivity and identity. The paper attends to these experiences and to how the dancers' actions extend existing conceptions of diplomatic subjectivity by considering vulnerability. In examining these dynamics, the paper also contributes to existing work on art and geopolitics, both through its diplomatic focus and its analysis of how diplomatic and creative practices were intertwined through an aesthetic of quietness. It thus attends to how geopolitical aesthetics matter, and how, in this instance, quiet aesthetics were a mark of international disempowerment.
Influenza D virus exposure among US cattle workers: A call for surveillance
Authors: Leibler Jessica H. , Abdelgadir Anfal , Seidel James , White Roberta F. , Johnson W. Evan , Reynolds Stephen J. , Gray Gregory C. , Schaeffer Joshua W. 
Published: November 2022

AbstractAlthough cattle are a reservoir for influenza D virus (IDV), little is known about human exposure to IDV. We assessed IDV exposure and associated health effects among United States dairy workers, a population at heightened risk of cattle zoonoses. In prospective, cross‐shift sampling of 31 workers employed at five large‐herd dairy operations in two states, we found evidence of IDV in the nasal washes of 67% of participants at least once during the 5‐day study period. IDV exposure was not associated with respiratory symptoms in these workers. These findings suggest that IDV is present in dairy cattle environments and can result in worker exposure.
Elliptical Bladed Savonius Rotor for Wind Energy: Efficacy of RANS Modeling for Flow Characteristics
Authors: Dewan Anupam , Bishnoi Ashok Kumar , Singh Tej Pratap , Tomar Shivam Singh 
Published: November 2022

Abstract
Wind energy is a key contributor to renewable energy production. Vertical axis wind turbine (VAWT) of Savonius type is advantageous in places of small-scale power production and low wind speed regions. It is a VAWT of the drag-based type. The disadvantage of a Savonius rotor is its low efficiency due to the generation of negative torque on the returning blade. To reduce the negative torque, the performance parameters of a Savonius rotor need to be optimized. The shear-stress transport variant of k–ω turbulence model is used in the current study to compute 2D unsteady Reynolds-averaged Navier–Stokes calculations for an ellipse shape blade Savonius rotor to capture its aerodynamic behavior. The flow complexities, such as vortex generation and circulation, are analyzed for four different azimuthal angles 0deg, 45deg, 90deg, and 135deg for a tip speed ratio (TSR) of 0.8. A rise in CD to 1.0 at TSR equal to 0.9 indicates an adverse pressure gradient region on the forward-moving blade. The circulation studied in the present paper could be of practical importance in situations involving an array of Savonius rotors to find an optimum rotor position and rotational direction as in the case of horizontal axis wind turbine (HAWT).
Brain Endurance Training Improves Physical, Cognitive, and Multitasking Performance in Professional Football Players
Authors: Staiano Walter , Merlini Michele , Romagnoli Marco , Kirk Ulrich , Ring Christopher , Marcora Samuele 
Published: November 2022

Purpose: Brain endurance training (BET)—the combination of physical training with mentally fatiguing tasks—could help athletes adapt and increase their performance during sporting competitions. Here we tested whether BET completed after standard physical training improved physical and mental performance more than physical training alone during a preseason football training camp. Methods: The study employed a pretest/training/posttest design, with 22 professional football players randomly assigned to BET or a control group. Both groups completed 40 physical training sessions over 4 weeks. At the end of a day of physical training, the BET group completed cognitive training, whereas the control group listened to neutral sounds. Players completed the 30–15 Intermittent Fitness Test, repeated sprint ability random test, soccer-specific reactive agility test, and Stroop and psychomotor vigilance tests pretraining and posttraining. Mixed analysis of variance was used to analyze the data. Results: In the posttest (but not pretest) assessments, the BET group consistently outperformed the control group. Specifically, the BET group was faster (P = .02–.04) than the control group during the 30–15 Intermittent Fitness Test, the directional phase of the repeated sprint ability random test, and the soccer-specific reactive agility test. The BET group also made fewer errors (P = .02) during the soccer-specific reactive agility test than the control group. Finally, the BET group responded faster (P = .02) on the Stroop test and made fewer (P = .03) lapses on the psychomotor vigilance test than the control group. Conclusion: The inclusion of BET during the preseason seems more effective than standard physical training alone in improving the physical, cognitive, and multitasking performance of professional football players.
Dynamics of a SIR epidemic model with variable recruitment and quadratic treatment
Authors: Mukherjee Manisha , Mondal Biswajit 
Published: November 2022

The dynamical behavior of a variable recruitment SIR model has been investigated with the nonlinear incidence rate and the quadratic treatment function for a horizontally transmitted infectious disease that sustains for a long period (more than one year). For a long duration, we have incorporated human fertility in variable recruitment. The societal effort, i.e. all types of medical infrastructures, have a vital role in controlling such a disease. For this reason, we have considered the quadratic treatment function, which divides the system into two subsystems. We have established the existence and stability of different equilibrium points that depend mainly on the societal effort parameter in both subsystems and also global stability. Different rich dynamics such as forward bifurcation, Hopf bifurcation, limit cycle, and Bogdanov–Takens bifurcation of co-dimension 2 have been established by using bifurcation theory and the biological significance of these dynamics has been explained. Different numerical examples have been considered to illustrate the theoretical results. Finally, we have discussed the advantage of our model with the model by Eckalbar and Eckalbar [Nonlinear Anal.: Real World Appl. 12 (2011) 320–332].
Fairing of discrete planar curves to integrable discrete analogue of Euler’s elasticae
Authors: Zurita Sebastián Elías Graiff , Kajiwara Kenji , Suzuki Toshitomo 
Published: November 2022

We construct a method for fairing a given discrete planar curve by using the integrable discrete analog of Euler’s elastica, which is a discrete version of the approximation algorithm presented by Brander et al. We first give a brief review of the integrable discrete analog of Euler’s elastica proposed by Bobenko and Suris, then we present a detailed account of the fairing algorithm, and we apply this method to an architectural problem of characterizing the keylines of Japanese handmade pantiles.
Qu'est-ce qu'une épopée "nationale" ?
Authors: Boris Maeva 
Published: November 2022

Cette étude centrée sur le discours critique vise à interroger les formes de nationalisation dans le commentaire : c’est-à-dire l’ensemble des opérations mises en œuvre par la critique quand elle commente un texte à l’aune d’un espace national. On se propose à cet effet d’étudier un ensemble de commentaires d’épopées dans lesquelles évoluent l’expression « épopée nationale ». On interrogera le degré de lexicalisation de la formule afin de comprendre dans quelle mesure la critique peut présupposer l’existence d’une catégorie générique « épopée nationale », s’y référer et l’intégrer dans des stratégies herméneutiques, sans pour autant la nommer textuellement. On mettra en regard des pratiques discursives contemporaines avec un ensemble d’études de la fin du XIXe siècle déterminé par un contexte épistémique tributaire d’une pensée nationaliste de la littérature.
Mots-Clefs: critique littéraire; genre littéraire; épopée; nation.
On mettra en regard des pratiques discursives contemporaines avec un ensemble d’études de la fin du XIXe siècle déterminés par un contexte épistémique tributaire d’une pensée nationaliste de la littérature.