bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anomaly detection by using a combination of generative adversarial networks and convolutional autoencoders
Authors: Luo Xukang , Jiang Ying , Wang Enqiang , Men Xinlei 
Published: November 2022

AbstractWith the development of full digitalization, the amount of time series data generated by sensors is ever-increasing; thus, time series outlier detection has become crucial. Moreover, in practice, discovering and flagging anomalies is very time-consuming and expensive. To solve this problem, unsupervised anomaly detection methods have often been used in the past, in which the model is trained with normal data to learn its behavioral patterns. Generative adversarial networks (GANs) can simulate complex and high-dimensional distributions of data and can be used to learn the behavioral patterns of normal data for unsupervised anomaly detection. However, because of the problem of convergence, GANs are difficult to train. Thus, USADs (an unsupervised anomaly detection model) utilize an autoencoder (AE) to undertake the task of the generator and discriminator and enhance the stability during adversarial training by using the AE to alleviate the problem of non-convergence encountered in GANs. Therefore, in this study, we used the USAD’s generative adversarial training architecture combined with convolutional AEs to improve the model’s feature extraction capabilities. In addition, to reduce false-positive outcomes caused by the prominent sharp points in the reconstructed data, we used the exponential weighted moving average method to smooth the reconstruction error, thereby improving the anomaly detection accuracy of the model. Finally, we experimented with real-world time-series data (ECG and 2D gesture) and verified that our approach could improve accuracy. Compared to the best in the comparison method, our model improved by 0.028% in AUROC, 0.233% in AUPRC, and 0.187% in F1 on average.
Using a theoretical framework to inform implementation of the patient-centred medical home (PCMH) model in primary care: protocol for a mixed-methods systematic review
Authors: Mazevska Deniza , Pearse Jim , Tierney Stephanie 
Published: November 2022

Abstract
Background
The patient-centred medical home (PCMH) was conceived to address problems that primary care practices around the world are facing, particularly in managing the increasing numbers of patients with multiple chronic diseases. The problems include fragmentation, lack of access and poor coordination. The PCMH is a complex intervention combining high-quality primary care with evidence-based disease management. Becoming a PCMH takes time and resources, and there is a lack of empirically informed guidance for practices. Previous reviews of PCMH implementation have identified barriers and enablers but failed to analyse the complex relationships between factors involved in implementation. Using a theoretical framework can help with this, giving a better understanding of how and why interventions work or do not work. This review will aim to refine an existing theoretical framework for implementing organisational change — the Consolidated Framework for Implementation Research (CFIR) — to apply to the implementation of the PCMH in primary care.

Methods
We will use the ‘best-fit’ framework approach to synthesise evidence for implementing the PCMH in primary care. We will analyse evidence from empirical studies against CFIR constructs. Where studies have identified barriers and enablers to implementing the PCMH not represented in the CFIR constructs, we will use thematic analysis to develop additional constructs to refine the CFIR. Searches will be undertaken in MEDLINE (Ovid), Embase (Ovid), Web of Science Core Collection (including Science Citation Index and Social Science Citation Index) and CINAHL. Gaps arising from the database search will be addressed through snowballing, citation tracking and review of reference lists of systematic reviews of the PCMH. We will accept qualitative, quantitative and mixed methods primary research studies published in peer-reviewed publications. A stakeholder group will provide input to the review.

Discussion
The review will result in a refined theoretical framework that can be used by primary care practices to guide implementation of the PCMH. Narrative accompanying the refined framework will explain how the constructs (existing and added) work together to successfully implement the PCMH in primary care. The unpopulated CFIR constructs will be used to identify where further primary research may be needed.

Systematic review registration
PROSPERO CRD42021235960
Water, land, and air: how do residents of Brazilian remote rural territories travel to access health services?
Authors: Almeida Patty Fidelis de , Santos Adriano Maia dos , Silva Cabral Lucas Manoel da , Anjos Eduarda Ferreira dos , Fausto Márcia Cristina Rodrigues , Bousquat Aylene 
Published: November 2022

Abstract
Background
Ensuring adequate and safe means of travel is essential for maintaining and improving the health and well-being of residents of rural communities worldwide. This article maps costs, distances, travel times, and means of elective and urgent/emergency health transport in Brazilian remote rural municipalities.

Methods
Multiple case studies were conducted in 27 remote rural municipalities using a qualitative method. A total of 178 key informants (managers, doctors, and nurses) were interviewed. Secondary data from national information systems were analyzed for the socioeconomic characterization, to identify the costs, distances, and travel times. Through the thematic content analysis of the interviews, the means of transport, and strategies developed by managers, professionals and users for their provision were identified.

Results
The costs of traveling between remote rural municipalities and locations where most of specialized and hospital services are centered can compromise a significant part of the families’ income. The insufficiency, restriction of days, times, and routes of health transport affects the selection of beneficiaries based on socioeconomic criteria in places of high vulnerability and less investment in road infrastructure. In remote rural municipalities, travelling to seek health care involves inter-municipal and intra-municipal flows, as their territories have dispersed populations. Several means of transport were identified – air, river, and land – which are often used in a complementary way in the same route. Some patients travel for more than 1000 km, with travel times exceeding 20 h, especially in the Amazon region. While the demands for urgent and emergency transport are partially met by national public policy, the same is not true for the elective transport of patients. The impossibility of providing health transport under the exclusive responsibility of the municipalities is identified.

Conclusions
For the remote rural municipalities populations, the absence of national public policies for sufficient, continuous, and timely provision of transport for health services worsens the cycle of inequities and compromises the assumption of the universal right to health care.
Success rates of MRSA decolonization and factors associated with failure
Authors: Yiek Wing-Kee , Tromp Mirjam , Strik-Albers Riet , van Aerde Koen , van der Geest-Blankert Nannet , Wertheim Heiman F. L. , Meijer Corianne , Tostmann Alma , Bleeker-Rovers Chantal P. 
Published: November 2022

Abstract
Background
We evaluated the success rate of MRSA decolonization directly after treatment and after one year in patients who were treated at the outpatient MRSA clinic of a large university medical centre to identify potential contributing factors to treatment success and failure.

Methods
Data from November 1, 2013 to August 1, 2020 were used. Only patients who had undergone complete MRSA decolonization were included. Risk factors for MRSA treatment failure were identified using a multivariable logistic regression model.

Results
In total, 127 MRSA carriers were included: 7 had uncomplicated carriage, 91 had complicated carriage, and 29 patients had complicated carriage in combination with an infection. In complicated carriers and complicated carriers with an infection final treatment was successful in 75.0%. Risk factors for initial treatment failure included having one or more comorbidities and not testing the household members. Risk factors for final treatment failure were living in a refugee centre, being of younger age (0–17 years), and having one or more comorbidities.

Conclusions
The results of this study indicate that patients with a refugee status and children treated at the paediatric clinic have a higher risk of MRSA decolonisation treatment failure. For this reason, it might be useful to revise decolonization strategies for these subgroups and to refer these patients to specialized outpatient clinics in order to achieve higher treatment success rates.
Evaluation of interrelatedness of cities in the territorial space of Russia
Authors: Manaeva Inna , Rastvortseva Svetlana , Kanishcheva Aleksandra 
Published: November 2022

AbstractThe purpose of the article is to carry out the analysis of interrelatedness of cities in the territorial space of Russia. The evaluation method is based on the calculation of global and local Moran's indexes for determination of interrelatedness of the adjacent territories by the following parameters: "population size", "population density", "average monthly salary", "shipping volume per capita". Represented as the study object were cities of the Volga Federal District of Russia with a population size over 100 thousand people in 2017. As a result of the calculations performed the leading cities were determined for all researched parameters. The quantitative evaluations obtained by the authors can be used for investigation of the leading cities effects and determination of the region development strategies.
Preliminary validation of the pica, ARFID and rumination disorder interview ARFID questionnaire (PARDI-AR-Q)
Authors: Bryant-Waugh Rachel , Stern Casey M. , Dreier Melissa J. , Micali Nadia , Cooke Lucy J. , Kuhnle Megan C. , Burton Murray Helen , Wang Shirley B. , Breithaupt Lauren , Becker Kendra R. , Misra Madhusmita , Lawson Elizabeth A. , Eddy Kamryn T. , Thomas Jennifer J. 
Published: November 2022

Abstract
Background
The Pica, ARFID, and Rumination Disorder Interview (PARDI) is a structured interview that can be used to determine diagnosis, presenting characteristics, and severity across three disorders, including avoidant/restrictive food intake disorder (ARFID). The purpose of this study was to evaluate the psychometric properties of a questionnaire focused specifically on ARFID (PARDI-AR-Q), which has the potential to provide related information with less participant burden.

Methods
Adolescents and adults (n = 71, ages 14–40 years) with ARFID (n = 42) and healthy control participants (HC, n = 29) completed the PARDI-AR-Q and other measures. A subset of the ARFID group (n = 27) also completed the PARDI interview.

Results
An exploratory factor analysis of proposed subscale items identified three factors corresponding to the ARFID phenotypes of avoidance based on the sensory characteristics of food, lack of interest in eating or food, and concern about aversive consequences of eating. Further analyses supported the internal consistency and convergent validity of the PARDI-AR-Q subscales, and subscale ratings on the questionnaire showed large and significant correlations (all p-values < 0.001; r’s ranging from 0.48 to 0.77) with the corresponding subscales on the interview. The ARFID group scored significantly higher than HC on all subscales. Furthermore, 90% of the ARFID group scored positive on the PARDI-AR-Q diagnostic algorithm while 93% of the HC scored negative.

Conclusions
Though replication in larger and more diverse samples is needed, findings provide early support for the validity of the PARDI-AR-Q as a self-report measure for possible ARFID in clinical or research settings.
Home care nurses’ management of high-risk medications: a cross-sectional study
Authors: Dumitrescu Irina , Casteels Minne , De Vliegher Kristel , Mortelmans Laura , Dilles Tinne 
Published: November 2022

AbstractBackgroundHigh-risk medications use at home entails an increased risk of significant harm to the patient. While interventions and strategies to improve medications care have been implemented in hospitals, it remains unclear how this type of medications care is provided in the home care setting. The objective was to describe home care nurses’ management of high-risk medications.MethodsA cross-sectional, descriptive design was set up in home care nurses in Flanders, Belgium. Participants were recruited through convenience sampling and could be included in the study if they provided medications care and worked as a home care nurses. Participants completed an online structured questionnaire. Questions were asked about demographic information, work experience, nurses’ general attitude regarding high-risk medications, contact with high-risk medications and the assessment of risk and severity of harm, specific initiatives undertaken to improve high-risk medications care and the use of additional measures when dealing with high-risk medications. Descriptive statistics were used.ResultsA total of 2283 home care nurses participated in this study. In our study, 98% of the nurses reported dealing high-risk medications. Home care nurses dealt the most with anticoagulants (96%), insulin (94%) and hypnotics and sedatives (87%). Most nurses took additional measures with high-risk medications in less than 25% of the cases, with the individual double check being the most performed measure for all high-risk medications except lithium. Nurses employed by an organization received support mostly in the form of a procedure while self-employed nurses mostly look for support through external organizations and information sources.ConclusionsThe study shows several gaps regarding high-risk medications care, which can imply safety risks. Implementation and evaluation of more standardized high-risk medications care, developing and implementing procedures or guidelines and providing continuous training for home care nurses are advised.
Clinical performance of immediately placed and restored progressive-type implants in the esthetic zone: a prospective observational study
Authors: Trimpou G. , Schwarz F. , Begić A. , Hess P. , Lermen J. , Keim N. , Obreja K. , Parvini P. 
Published: November 2022

Abstract
Purpose
To assess implant success and survival of immediately placed and restored progressive-type implants in the esthetic zone.

Material and methods
A total of n = 21 patients (21 implants) had received an immediate placement of a tapered, two-part implant with a progressive thread design (PL) for a single tooth replacement in the anterior maxilla. An immediate ‘non full-functional loaded’ restoration was provided upon adequate primary stability on a final patient-specific abutment (one abutment-one time concept). The final restoration was provided at 12 weeks (baseline). Implant survival and success (e.g. bleeding on probing—BOP, probing pocket depth—PD, mucosal recession—MR, pink esthetic score—PES) as well as patient- reported outcomes (PROM`S) were recorded at 6 and 12 months.

Results
An adequate primary implant stability (i.e. insertion torque > 35 Ncm) was obtained at all but one sites. At 12 months, implant survival (n = 20 patients) amounted to 100%. Non-significant changes to baseline were noted for mean BOP (2.5 ± 28.2%), PD (− 0.26 ± 0.73 mm), and MR (0.0 ± 0.4 mm) values. PES values amounted to 12.9 ± 1.14 and 13.2 ± 0.84 at 6 and 12 months. Technical and mechanical complications were not observed. Patients expressed an overall high satisfaction.

Conclusions
The presented immediacy protocol was associated with high survival and success rates on the short-term.

Graphical Abstract
Intraoperative chlorhexidine-induced anaphylaxis suggesting an immunoglobulin-E-dependent mechanism indicated by basophil activation tests: two case reports
Authors: Orihara Masaki , Takazawa Tomonori , Horiuchi Tatsuo , Nagumo Kazuhiro , Maruyama Noboru , Tomioka Akihiro , Saito Shigeru 
Published: November 2022

Abstract
Background
Although chlorhexidine allergy has been shown to be mediated by immunoglobulin (Ig) E, few reports investigated the mechanism of chlorhexidine-induced anaphylaxis using basophil activation tests (BATs).

Case presentation
A 79-year-old man underwent cholecystectomy under general anesthesia. Anaphylaxis was diagnosed based on the clinical symptoms and high serum tryptase and histamine levels. Skin tests showed positive results only for chlorhexidine. Subsequently, BATs demonstrated that the causative agent was likely chlorhexidine. The inhibitory effect of wortmannin, an inhibitor of phosphoinositide 3-kinase, on basophil activation suggested an IgE-dependent mechanism underlying chlorhexidine-induced anaphylaxis.
An 89-year-old man underwent inguinal hernioplasty under general anesthesia. Anaphylaxis was diagnosed based on the clinical symptoms and high serum tryptase and histamine levels. Skin tests and BATs with wortmannin were performed, showing similar results to case 1.

Conclusions
BATs suggested an IgE-dependent mechanism for chlorhexidine-induced anaphylaxis and might be useful for investigating the mechanisms underlying drug-induced anaphylaxis.
Effect of cup, syringe, and finger feeding on time of oral feeding of preterm neonate’s: a randomized controlled clinical trial
Authors: Alinezhad Shebilouysofla Parinaz , Mostafa Gharebaghi Manizheh , Sattarzadeh Jahdi Niloufar , Abdoli Najmi Leila , Hakimi Sevil 
Published: November 2022

Abstract
Background
The oral nutrition is big challenge for preterm neonates. Since the best oral feeding method for preterm neonates is not yet known, the present study aimed to evaluate the effect of cup, syringe, and finger feeding methods on reaching the time of full oral feeding and weight gain among preterm neonates.

Method
This randomized clinical trial study was conducted on 99 preterm neonate’s, born at 30–34 weeks gestation, admitted to the neonatal intensive care unit (NICU) of Al-Zahra and Taleghani Therapeutic-Educational Centers in Tabriz, Iran. Subjects were assigned into finger feeding (n = 33), cup feeding (n = 33), and syringe feeding (n = 33) groups in the allocation ratio of 1:1:1 using block randomization with a block size 6 and 9. They were studied in terms of reaching the time of full oral feeding and weight gain. The data were analyzed using SPSS/version21 software, and ANOVA, chi-square, and ANCOVA tests.

Results
There was no significant difference in the mean score of reaching the time of full oral feeding among cup, finger, and syringe feeding groups (p = 0.652). The mean score of daily weight gain, oxygen saturation (SaO2), and heart rate after feeding was not significantly different among the three groups (p > 0.05). The effect of confounding variables, including birth weight and age, arterial oxygen saturation, and heart rate before feeding, was controlled.

Conclusion
Based on the results, one of the cup, finger, and syringe feeding methods can be applied in the NICU, considering the staff’s proficiency in feeding neonates.
Trial registration IRCT20150424021917N11.
Psychological burden in spinal muscular atrophy patients and their families: a systematic review
Authors: Sari Dian Marta , Wijaya Laurentia Cindy Gani , Sitorus Wintoro Duraman Roives , Dewi Mia Milanti 
Published: November 2022

Abstract
Background
Spinal muscular atrophy (SMA) is an autosomal-recessive disorder that manifests in paralysis and skeletal muscle weaknesses. This neuromuscular problem is caused by degeneration of the spinal cord anterior horn cells.

Main body of the abstract
SMA leads to a decreased motoric function that affects patients’ daily activity and eventually induces the psychological burden. Given the increasing psychological burden of the patients and their families, this review summarizes the studies assessing the psychological burden of SMA patients and their families. We aimed to highlight the leading causes of their psychological burden. We systematically searched literature from the period 2011 to 2020 in two electronic databases by using the keywords “Spinal Muscular Atrophy”, “Psychology”, “Caregivers”, and “Burden”, then filtered it with the eligibility criteria and screened the abstract of the studies. By searching, screening, and filtering the studies, we included seven studies in this review. This review showed an increasing psychological burden in SMA patients, moreover for the parents. The dependency mainly causes the psychological burden since they eagerly struggle to achieve an everyday life.

Conclusion
Health professionals’ understanding capability regarding the mental condition of patients and their families is a potential aspect that can create better care. This review is encouraging for researchers and clinicians to have an enormous understanding of SMA.
Subdural collection after transcortical approach for pediatric brain tumors; avoidance, consequence and solutions
Authors: Elhabashy Abdelrahman Magdy , Fayed Ahmed Abdelaziz , Khedr Wael M. 
Published: November 2022

Abstract
Introduction
Subdural collections, following brain surgeries in pediatrics, are common and unfortunately not always easily treated; especially in huge parenchymal tumors, intraventricular tumors and paraventricular tumors. Different approaches for prevention and treatment of theses subdural collections have been discussed by several studies, but till now no solid consensus has been reached. One of these approaches is to approximate incised cortical edges by suturing the pia, use of fibrin adhesive glue and subsequent Ringer inflation. The aim of our study is to avoid cortical mantle collapse and to prevent the development of progressive pressurizing subdural fluid collections.

Patients and methods
This study included 12 pediatric cases operated for large sized brain tumors between 2014 and 2019, in the department of Pediatric Neurosurgery at Alexandria University. All cases were operated via transcortical approach. Patients were followed prospectively for postoperative complications including postoperative subdural collections. In all patients, gel foam and fibrin glue on the cortical and ependymal edges, with suture approximation of the cortical edges and subsequent Ringer lactate inflation in the residual cavity were routinely done.

Results
With the consecutive follow-up images, six cases (50%) showed persistent subdural collection following tumor resection. Three cases had 5–6 mm asymptomatic subdural collection thickness that resolved within 3 to 6 months, and the rest three cases showed more than 7 mm thickness subdural collection. In these 3/12 (25%) cases patients had symptomatic and progressive increase in the subdural fluid collections. A subdural-peritoneal shunt was necessary only for 1 patient (8%). After finishing his adjuvant therapy, it was possible to remove the subdural-peritoneal shunt. While in the other 2 patients, the subdural collection was managed surgically with just a burr hole evacuation. The clinical manifestations resolved postoperatively but complete resolution of these 2 subdural collections occurred within 7 and 9 months.

Conclusion
The use of sutures and fibrin adhesive to seal surgical defects with inflation of the residual cavity with Ringer lactate solution might decrease the development of subdural fluid collections, through avoiding the cortical mantle collapse.