bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunologic constant of rejection signature is prognostic in soft-tissue sarcoma and refines the CINSARC signature
Authors: Bertucci Francois , Niziers Vincent , de Nonneville Alexandre , Finetti Pascal , Mescam Léna , Mir Olivier , Italiano Antoine , Le Cesne Axel , Blay Jean-Yves , Ceccarelli Michele , Bedognetti Davide , Birnbaum Daniel , Mamessier Emilie 
Published: January 2022

BackgroundSoft-tissue sarcomas (STSs) are heterogeneous and aggressive tumors, with high metastatic risk. The immunologic constant of rejection (ICR) 20-gene signature is a signature of cytotoxic immune response. We hypothesized that ICR might improve the prognostic assessment of early-stage STS.MethodsWe retrospectively applied ICR to 1455 non-metastatic STS and searched for correlations between ICR classes and clinicopathological and biological variables, including metastasis-free survival (MFS).ResultsThirty-four per cent of tumors were classified as ICR1, 27% ICR2, 24% ICR3, and 15% ICR4. These classes were associated with patients’ age, pathological type, and tumor depth, and an enrichment from ICR1 to ICR4 of quantitative/qualitative scores of immune response. ICR1 class was associated with a 59% increased risk of metastatic relapse when compared with ICR2-4 class. In multivariate analysis, ICR classification remained associated with MFS, as well as pathological type and Complexity Index in Sarcomas (CINSARC) classification, suggesting independent prognostic value. A prognostic clinicogenomic model, including the three variables, was built in a learning set (n=339) and validated in an independent set (n=339), showing greater prognostic precision than each variable alone or in doublet. Finally, connectivity mapping analysis identified drug classes potentially able to reverse the expression profile of poor-prognosis tumors, such as chemotherapy and targeted therapies.ConclusionICR signature is independently associated with postoperative MFS in early-stage STS, independently from other prognostic features, including CINSARC. We built a robust prognostic clinicogenomic model integrating ICR, CINSARC, and pathological type, and suggested differential vulnerability of each prognostic group to different systemic therapies.
Herpes zoster in SLE: prevalence, incidence and risk factors
Authors: Kwan Andrew , Rayes Hanan Al , Lazova Tijana , Anderson Nicole , Bonilla Dennisse , Su Jiandong , Touma Zahi 
Published: January 2022

ObjectivesThis study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events and describe its associated factors in a study of patients with SLE.Methods491 consecutive SLE participants were screened for HZ events using a patient-reported questionnaire to capture outcomes on pain and other characteristics associated with HZ events. Sociodemographic, clinical and laboratory measures were also analysed, and time-dependent Cox regression survival analyses were performed to investigate factors associated with HZ events.ResultsPrevalence of HZ was 30.5%, incidence was 14.3 cases per 1000 person-years. Lymphopenia and glucocorticoid dosing were significantly associated with HZ events.ConclusionsHZ is highly prevalent in SLE, which may be linked to disease-related and treatment-related effects on cellular immunity. Our results suggest that the presence of certain risk factors may be useful to allow identification of patients at risk of HZ and improve its management in patients with SLE.
Long-term exposure to air pollution and COVID-19 incidence: a prospective study of residents in the city of Varese, Northern Italy
Authors: Veronesi Giovanni , De Matteis Sara , Calori Giuseppe , Pepe Nicola , Ferrario Marco M 
Published: January 2022

ObjectivesTo investigate the association between long-term exposure to airborne pollutants and the incidence of SARS-CoV-2 up to March 2021 in a prospective study of residents in Varese city.MethodsCitizens of Varese aged ≥18 years as of 31 December 2019 were linked by residential address to 2018 average annual exposure to outdoor concentrations of PM2.5, PM10, NO2, NO and ozone modelled using the Flexible Air quality Regional Model (FARM) chemical transport model. Citizens were further linked to regional datasets for COVID-19 case ascertainment (positive nasopharyngeal swab specimens) and to define age, sex, living in a residential care home, population density and comorbidities. We estimated rate ratios and additional numbers of cases per 1 µg/m3increase in air pollutants from single- and bi-pollutant Poisson regression models.ResultsThe 62 848 residents generated 4408 cases. Yearly average PM2.5exposure was 12.5 µg/m3. Age, living in a residential care home, history of stroke and medications for diabetes, hypertension and obstructive airway diseases were independently associated with COVID-19. In single-pollutant multivariate models, PM2.5was associated with a 5.1% increase in the rate of COVID-19 (95% CI 2.7% to 7.5%), corresponding to 294 additional cases per 100 000 person-years. The association was confirmed in bi-pollutant models; excluding subjects in residential care homes; and further adjusting for area-based indicators of socioeconomic level and use of public transportation. Similar findings were observed for PM10, NO2and NO. Ozone was associated with a 2% decrease in disease rate, the association being reversed in bi-pollutant models.ConclusionsLong-term exposure to low levels of air pollutants, especially PM2.5, increased the incidence of COVID-19. The causality warrants confirmation in future studies; meanwhile, government efforts to further reduce air pollution should continue.
Differential impact of the Canadian point-of-sale tobacco display bans on quit attempts and smoking cessation outcomes by sex, income and education: longitudinal findings from the ITC Canada Survey
Authors: Usidame Bukola , Xie Yanmei , Thrasher James F , Lozano Paula , Elliott Michael R , Fong Geoffrey T , Fleischer Nancy L 
Published: January 2022

SignificanceThis study examines the differential effects of Canadian point-of-sale (POS) tobacco display bans across provinces on quit attempts and smoking cessation, by sex, education and income.MethodsWe analysed survey data from five waves (waves 4–8) of the International Tobacco Control Canada Survey, a population-based, longitudinal survey, where provinces implemented display bans between 2004 and 2010. Primary outcomes were quit attempts and successful cessation. We used generalised estimating equation Poisson regression models to estimate associations between living in a province with or without a POS ban (with a 24-month threshold) and smoking outcomes. We tested whether these associations varied by sex, education and income by including interaction terms.ResultsAcross survey waves, the percentage of participants in provinces with POS bans established for more than 24 months increased from 5.0% to 95.8%. There was no association between POS bans and quit attempts for provinces with bans in place for 0–24 months or more than 24 months, respectively (adjusted relative risk (aRR)=0.99, 95% CI: 0.89 to 1.10; 1.03, 95% CI: 0.88 to 1.20). However, we found a differential impact of POS bans on quit attempts by sex, whereby bans were more effective for women than men for bans of 0–24 months. Participants living in a province with a POS ban for at least 24 months had a higher chance of successful cessation (aRR=1.49; 95% CI: 1.08 to 2.05) compared with those in a province without a ban. We found no differences in the association between POS bans and quit attempts or cessation by education or income, and no differences by sex for cessation.ConclusionPOS bans are associated with increased smoking cessation overall and more quit attempts among women than men.
Can phytogenic additives improve the performance of broilers and replace growth-promoting antibiotics? A meta-analytic approach
Authors: Polycarpo Gustavo do Valle , Lima Gabrieli Andressa de , Ávida Thaís de Souza , Rosas Fábio Sampaio , Cruz-Polycarpo Valquíria Cação , Biller Jaqueline Dalbello , Barbosa Bárbara Fernanda da Silva , Burbarelli Maria Fernanda de Castro 
Published: January 2022

Phytogenic additives have been studied intensively in broiler chicken production to substitute growth-promoting antibiotics. However, the comprehensive literature on this topic makes it difficult to understand overall results because there are a noticeable number of studies with conflicting conclusions. While several research studies have shown that phytogenic additives may increment broiler chicken’s performance, others make the opposite evident. This study aimed to organize and understand information through meta-analysis considering a great number of publications and the factors that may interfere in the results of phytogenic additives, evaluating whether phytogenic additives can be used as a performance-enhancing additive for broilers, when compared with the effectiveness of growth-promoting antibiotics. The main factor that interferes in the evaluation of phytogenic additives is the microbiological challenge. Phytogenic additives improved average daily gain (ADG) (P < 0.001) and feed conversion (P < 0.001) regardless of microbiological challenge; however, they were worse compared with antibiotics under higher challenge (P < 0.020). A meta-regression of ADG in function of average daily feed intake confirmed that phytogenic additives increased the feed efficiency of broilers, but with less effectiveness than antibiotics. The blends of phytogenic additives increased the ADG in relation to the isolated use of only one phytogenic additive.
On stringy origin of minimal flavor violation
Authors: Kobayashi Tatsuo , Otsuka Hajime 
Published: January 2022

AbstractWe study the minimal flavor violation in the context of string effective field theory. Stringy selection rules indicate that n-point couplings among fermionic zero-modes and lightest scalar modes in the string effective action are given by a product of Yukawa couplings which are regarded as spurion fields of stringy and geometrical symmetries. Hence, Yukawa couplings determine the dynamics of flavor and CP violations. This observation strongly supports the hypothesis of minimal flavor violation in the Standard Model effective field theory.
New limits on double-beta decay of $$^{190}$$Pt and $$^{198}$$Pt
Authors: Danevich F. A. , Hult M. , Junghans A. , Kasperovych D. V. , Kropivyansky B. N. , Lutter G. , Marissens G. , Polischuk O. G. , Romaniuk M. V. , Stroh H. , Tessalina S. , Tretyak V. I. , Ware B. 
Published: January 2022

AbstractA search for double-beta decay of $$^{190}$$

190

Pt and $$^{198}$$

198

Pt with emission of $$\gamma $$
γ
-ray quanta was realized at the HADES underground laboratory with a 148 g platinum sample measured by two ultralow-background HPGe detectors over 8946 h. The isotopic composition of the platinum sample has been measured with high precision using inductively coupled plasma mass spectrometry. New lower limits for the half-lives of $$^{190}$$

190

Pt relative to different channels and modes of the decays were set on the level of $$\lim T_{1/2}\sim 10^{14}$$

lim

T

1
/
2

∼

10
14

–$$10^{16}$$

10
16

year. A possible exact resonant $$0\nu KN$$

0
ν
K
N

transition to the 1,2 1326.9 keV level of $$^{190}$$

190

Os is limited for the first time as $$T_{1/2} \ge 2.5 \times 10^{16}$$

T

1
/
2

≥
2.5
×

10
16

year. A new lower limit on the double-beta decay of $$^{198}$$

198

Pt to the first excited level of $$^{198}$$

198

Hg was set as $$T_{1/2} \ge 3.2\times 10^{19}$$

T

1
/
2

≥
3.2
×

10
19

year, one order of magnitude higher than the limit obtained in the previous experiment.
On a spanning subgraph of the annihilating-ideal graph of a commutative ring
Authors: Visweswaran S. 
Published: January 2022

The rings considered in this paper are commutative with identity which are not integral domains. Let [Formula: see text] be a ring. Let us denote the set of all annihilating ideals of [Formula: see text] by [Formula: see text] and [Formula: see text] by [Formula: see text]. With [Formula: see text], we associate an undirected graph, denoted by [Formula: see text], whose vertex set is [Formula: see text] and distinct vertices [Formula: see text] and [Formula: see text] are adjacent in this graph if and only if [Formula: see text] and [Formula: see text]. The aim of this paper is to study the interplay between the graph-theoretic properties of [Formula: see text] and the ring-theoretic properties of [Formula: see text].
xDNN: Inference for Deep Convolutional Neural Networks
Authors: D'Alberto Paolo , Wu Victor , Ng Aaron , Nimaiyar Rahul , Delaye Elliott , Sirasao Ashish 
Published: January 2022

We present xDNN, an end-to-end system for deep-learning inference based on a family of specialized hardware processors synthesized on Field-Programmable Gate Array (FPGAs) and Convolution Neural Networks (CNN). We present a design optimized for low latency, high throughput, and high compute efficiency with no batching. The design is scalable and a parametric function of the number of multiply-accumulate units, on-chip memory hierarchy, and numerical precision. The design can produce a scale-down processor for embedded devices, replicated to produce more cores for larger devices, or resized to optimize efficiency. On Xilinx Virtex Ultrascale+ VU13P FPGA, we achieve 800 MHz that is close to the Digital Signal Processing maximum frequency and above 80% efficiency of on-chip compute resources.
On top of our processor family, we present a runtime system enabling the execution of different networks for different input sizes (i.e., from 224× 224 to 2048× 1024). We present a compiler that reads CNNs from native frameworks (i.e., MXNet, Caffe, Keras, and Tensorflow), optimizes them, generates codes, and provides performance estimates. The compiler combines quantization information from the native environment and optimizations to feed the runtime with code as efficient as any hardware expert could write. We present tools partitioning a CNN into subgraphs for the division of work to CPU cores and FPGAs. Notice that the software will not change when or if the FPGA design becomes an ASIC, making our work vertical and not just a proof-of-concept FPGA project.
We show experimental results for accuracy, latency, and power for several networks: In summary, we can achieve up to 4 times higher throughput, 3 times better power efficiency than the GPUs, and up to 20 times higher throughput than the latest CPUs. To our knowledge, we provide solutions faster than any previous FPGA-based solutions and comparable to any other top-of-the-shelves solutions.
A Pilot Study of Gene Expression Analysis in Peripheral Blood Mononuclear Cells in Response to a Hypocaloric Mediterranean Diet
Authors: de Luis Daniel , Primo David , Izaola Olatz , Aller Rocío 
Published: January 2022

Background. Few studies have examined gene expression in peripheral blood mononuclear cells (PBMCs) after a dietary intervention. Objective. Our study is aimed at evaluating in a pilot study the peripheral blood gene expression in obese patients after weight loss secondary to a hypocaloric Mediterranean diet. Design. A sample of 11 obese subjects without metabolic syndrome was enrolled. Biochemical, anthropometric parameters and microarray analysis were performed at baseline and after 6 months of dietary intervention. Results. The mean age was

43.1
±
6.3

years, and the mean body mass index (BMI) was

38.6
±
8.1

kg/m2. All the next improvements were statistically significant: body weight

−
7.4
±
1.9

kg, BMI -

2.5
±
0.2

kg, fat mass

−
5.7
±
1.2

kg, waist circumference

−
5.8
±
1.2

cm, triglycerides

−
17.4
±
6.5

mg/dl, C-reactive protein

−
3.1
±
1.5

mg/dL, insulin

−
2.1
±
1.0

mUI/L, and HOMA-IR

−
0.7
±
0.2

units. We identified 634 differentially expressed genes: 262 genes with relative higher expression levels and 372 with lower expression levels. Cluster analysis showed 35 genes in nutritional disease and 17 genes in endocrine system. The most relevant gene was thyroid peroxidase (TPO), and this gene was overexpressed, and the next genes carbonic anhydrase VI (CA6), caveolin protein 1 (CAV1) and solute carrier family type 12 (SLLC12A3), soluble carrier family type 12 (SLLC12A3), beta 3 receptor (ADRB3), and glutamate receptor ionotropic N methyl D aspartate 2 A (GRIN2A) were all underexpressed. Conclusion. In PBMC from obese patients after a diet with a Mediterranean pattern, the expression of 634 genes, of the endocrine system and of nutritional disease, is modified.
Abstract IA-01: Health disparity research: The new frontier of research
Authors: Winn Robert A. 
Published: January 2022

Abstract
In 2020, the AACR's U.S. Cancer Disparities Progress Report showed that the there is still a significant gap in cancer incidence and mortality between white Americans and other racial and ethnic groups. That's not because the science hasn't progressed or because people of color are biologically predisposed to cancer. It's because the systems and structures put in place decades ago continue to harm the health of racial and ethnic minorities. Red-lining in the 1930s created segregated housing, and then the creation of the national highway system decimated majority-Black neighborhoods, leaving them treeless, polluted, and lacking healthy food and medical facilities. As a result, people living in these neighborhoods are more likely to get cancer and also more likely to die from it. So, when COVID-19 hit, many of us were not surprised that communities of color were disproportionately affected. And the current situation with COVID-19 vaccines is a great demonstration that while science is necessary for improving health, it's not sufficient. Those amazingly effective vaccines can't keep hospitals from being overwhelmed if a large chunk of the population won't get the shot, just as advances in cancer screening and treatment can't end disparities if they're predominantly going to wealthy white people. This realization has been one of our blind spots as scientists and physicians. Not only must work toward equitable access to care, but we must also work on building trust in medicine, which we do by demonstrating that we're trustworthy. There's a science to it, though we're going to have to allow for greater flexibility and messiness than we're accustomed to.
Citation Format: Robert A. Winn. Health disparity research: The new frontier of research [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-01.
TARA: Training and Representation Alteration for AI Fairness and Domain Generalization
Authors: Paul William , Hadzic Armin , Joshi Neil , Alajaji Fady , Burlina Philippe 
Published: January 2022

AbstractWe propose a novel method for enforcing AI fairness with respect to protected or sensitive factors. This method uses a dual strategy performing training and representation alteration (TARA) for the mitigation of prominent causes of AI bias. It includes the use of representation learning alteration via adversarial independence to suppress the bias-inducing dependence of the data representation from protected factors and training set alteration via intelligent augmentation to address bias-causing data imbalance by using generative models that allow the fine control of sensitive factors related to underrepresented populations via domain adaptation and latent space manipulation. When testing our methods on image analytics, experiments demonstrate that TARA significantly or fully debiases baseline models while outperforming competing debiasing methods that have the same amount of information—for example, with (% overall accuracy, % accuracy gap) = (78.8, 0.5) versus the baseline method's score of (71.8, 10.5) for Eye-PACS, and (73.7, 11.8) versus (69.1, 21.7) for CelebA. Furthermore, recognizing certain limitations in current metrics used for assessing debiasing performance, we propose novel conjunctive debiasing metrics. Our experiments also demonstrate the ability of these novel metrics in assessing the Pareto efficiency of the proposed methods.
Active Classification With Uncertainty Comparison Queries
Authors: Cui Zhenghang , Sato Issei 
Published: January 2022

Abstract
Noisy pairwise comparison feedback has been incorporated to improve the overall query complexity of interactively learning binary classifiers. The positivity comparison oracle is extensively used to provide feedback on which is more likely to be positive in a pair of data points. Because it is impossible to determine accurate labels using this oracle alone without knowing the classification threshold, existing methods still rely on the traditional explicit labeling oracle, which explicitly answers the label given a data point. The current method conducts sorting on all data points and uses explicit labeling oracle to find the classification threshold. However, it has two drawbacks: (1) it needs unnecessary sorting for label inference and (2) it naively adapts quick sort to noisy feedback. In order to avoid these inefficiencies and acquire information of the classification threshold at the same time, we propose a new pairwise comparison oracle concerning uncertainties. This oracle answers which one has higher uncertainty given a pair of data points. We then propose an efficient adaptive labeling algorithm to take advantage of the proposed oracle. In addition, we address the situation where the labeling budget is insufficient compared to the data set size. Furthermore, we confirm the feasibility of the proposed oracle and the performance of the proposed algorithm theoretically and empirically.
The 1994 Positive Indian Ocean Dipole Event as Investigated by the Transfer Routes of Oceanic Wave Energy
Authors: Li Zimeng , Aiki Hidenori 
Published: January 2022

Abstract
The present study investigates the interannual variability of the tropical Indian Ocean (IO) based on the transfer routes of wave energy in a set of 61-yr hindcast experiments using a linear ocean model. To understand the basic feature of the IO dipole mode, this paper focuses on the 1994 pure positive event. Two sets of westward transfer episodes in the energy flux associated with Rossby waves (RWs) are identified along the equator during 1994. One set represents the same phase speed as the linear theory of equatorial RWs, while the other set is slightly slower than the theoretical phase speed. The first set originates from the reflection of equatorial Kelvin waves at the eastern boundary of the IO. On the other hand, the second set is found to be associated with off-equatorial RWs generated by southeasterly winds in the southeastern IO, which may account for the appearance of the slower group velocity. A combined empirical orthogonal function (EOF) analysis of energy-flux streamfunction and potential reveals the intense westward signals of energy flux are attributed to off-equatorial RWs associated with predominant wind input in the southeastern IO corresponding to the positive IO dipole event.

Significance Statement
The present study gains a new insight into the mechanism of the Indian Ocean dipole events using a new diagnostic scheme for wave energy based on 61-yr hindcast experiments. The results have shown the existence of two sets of westward transfer of wave energy at the equator during 1994. One set of westward signals shows the same group velocity with theoretical equatorial Rossby waves that appear reasonably along the equator. The other set of westward signals at the equator represents a slightly slower group velocity than the theoretical equatorial Rossby waves, which is associated with abnormally extended southeasterly winds during the Indian Ocean dipole event.