bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyad learning versus individual learning under medical simulation conditions: a systematic review
Authors: Ding Jack , Xiao Xin , Biagi Shanon , Varkey Thomas 
Published: November 2022

Background: Dyad learning is a two-person learning dynamic in which one student observes the other performing tasks, with their roles then being reversed such that both students experience the observer and the performer role. The efficacy of dyad learning has been tested in medical education contexts, such as in medical simulation. To our knowledge, this is the first systematic review that has evaluated the efficacy of dyad learning in a medical simulation context. Methods: PubMed, Google Scholar, Cochrane Library databases were searched in September 2021 and January 2022. Prospective studies of randomized design that compared dyad learning to a single medical student or physician learning in a medical simulation were included. Non-English language studies, secondary literature papers, non-human based studies, and papers that were published prior to 2000 were excluded. The methodological quality of these studies was assessed using the Medical Education Research Study Quality Instrument (MERSQI). The Kirkpatrick model was used to conceptualize study outcomes. Results: The identified papers included eight studies from four countries that totaled 475 participants. Students reported positively on their experiences as dyads, especially regarding the social aspects of it. Studies showed non-inferior learning outcomes for dyads. As most studies were one or two days long, there is limited evidence that this non-inferiority extends to longer term training modules. There is some evidence to suggest that dyad learning outcomes may be replicable in a clinical context following simulation training. Conclusions: Dyad learning in medical simulation is a pleasant experience for students and may be as effective as conventional learning. These findings set the foundation for future studies of longer duration, which is needed to determine the efficacy of dyad learning in lengthier curriculums and long-term knowledge retention. While cost-reduction is an implied benefit, studies that explicate cost reduction are needed to formalize this.
Prevalence of hypertension and possible risk factors of hypertension unawareness among individuals aged 30–75 years from two Panamanian provinces: Results from population-based cross-sectional studies, 2010 and 2019
Authors: Del Rio Angela Isabel , Moreno Velásquez Ilais , Roa Reina , Montenegro Mendoza Roger , Motta Jorge , Quintana Hedley K. 
Published: November 2022

Background
Recent estimates of hypertension in Panama remain unknown. We aim to describe the variation in prevalence and unawareness of hypertension in two Panamanian provinces using two different cross-sectional population-based studies and to investigate risk factors associated with hypertension unawareness.

Methods
Data were derived from a sub-national study conducted in the provinces of Panama and Colon (PREFREC-2010 [2,733 participants]) and from a nationally representative study (ENSPA-2019), in which we restricted our analyses to the same provinces (4,653 participants). Individuals aged 30–75 years who had (a) self-reported history of hypertension or (b) blood pressure (BP) ≥140/90mmHg or (c) a combination or both were classified as hypertensive. Participants with BP≥140/90mmHg who denied a history of hypertension were considered unaware of the condition. Multivariable logistic regression models were used to estimate the association between risk factors and unawareness, expressed as odds ratios (OR) and 95% confidence interval (CI).

Findings
In 2010, the prevalence and unawareness of hypertension in men were 51.6% (95% CI: 45.7–57.5) and 32.3% (25.4–40.1), respectively, and in women 46.0% (42.1–49.9) and 16.1% (12.6–20.4), respectively. In 2019, the prevalence and unawareness of hypertension in men were 46.5% (42.1–51.0) and 52.3% (45.9–58.6), and in women 42.1% (39.6–44.7) and 33.3% (29.8–37.0). Men (2010 and 2019), age <50 years (2010 and 2019), having no/primary education (2010), and living in a non-urban region (2019) were positively associated with hypertension unawareness, whereas obesity (2010), physical inactivity (2010), family history of hypertension (2019), and BP assessment in the year before study enrollment (2010 and 2019) were inversely associated with hypertension unawareness.

Interpretation
Benefits of a decrease in the prevalence of hypertension are being undermined by an increase in hypertension unawareness. Actions should be encouraged to strengthen the implementation of the existing healthcare program for cardiovascular risk factor control.
Opioid and gabapentinoid prescriptions in England from 2015 to 2020
Authors: Xia Yixue , Forget Patrice 
Published: November 2022

Purpose
Concerns gradually arose about misuse of gabapentinoids (gabapentin and pregabalin), especially when used in combination with opioids. Because it can be a driver of usage, trends in prescribing habits may be interesting to analyse. The aim of this study is to examine the evolution of prescriptions of opioids and gabapentinoids in England from 2015 to 2020 at a regional level.

Methods
This study included data from April 2015 to February 2020, focusing on prescribing data, extracted the OpenPrescribing database. We described the evolution of the prescriptions of opioids and gabapentinoids and calculated their ratios for each month. We used Analyses of Variance (ANOVAs) to compare data between and within regions (over time).

Results
During this period, opioid prescriptions remained stable (from -3.3% to +2.2%/year) and increased for gabapentinoids generally (from +1.5% to +2.2%). The ratio between gabapentinoid to opioid prescriptions increased by more than 20% in 2020 compared to 2015, variably between regions (F(6,406) = [120.2]; P<0.001; LSD Test: P<0.001; ANOVA for repeated measures: P<0.05). In 2019, a decline in the ratio occurred in all regions, but only persisting in the London commissioning region in 2020 (-14.4% in comparison with 2018, 95%CI: -12.8 to -16.3).

Conclusions
Gabapentinoids are increasingly prescribed in England. The ratio of gabapentinoid to opioid prescriptions in England increased from 2015 to 2020. The reclassification of gabapentinoids as controlled drugs, in 2019, may have been associated with a significant reduction, although larger prescribers may have been less influenced.
Iodine status, household salt iodine content, knowledge and practice assessment among pregnant women in Butajira, South Central Ethiopia
Authors: Tadesse Senait , Hymete Ariaya , Lieberman Marya , Gebreyesus Seifu Hagos , Ashenef Ayenew 
Published: November 2022

Background
Iodine is one of the crucial micronutrients needed by the human body, and is vitally important during pregnancy. This study aimed to determine the relationship between the iodine status of pregnant women and their knowledge, and practices regarding iodized salt. All participants were enrolled in the Butajira nutrition, mental health and pregnancy (BUNMAP) cohort, Butajira, Ethiopia in February-May, 2019.

Methods
In this cross-sectional study, 152 pregnant women without hypertension or known thyroid disease before or during pregnancy were randomly selected from the BUNMAP mother to child cohort (n = 832). Spot urine samples were collected to estimate the level of urinary iodine concentration (UIC). Salt samples were also collected from their homes. The Sandall-Kolthoff (S-K) method was used to measure the level of iodine in the urine samples, and iodometric titration was used to measure the level of iodine in the salt. Data was entered and cleaned using Epi-info version 3.5.3 and then exported to SPSS version 20 for further analysis. Multivariate logistic regression analysis was performed to identify associations in the collected data.

Results
The WHO recommended level of iodine for populations of pregnant women is 150–249 F06Dg/L. The median UIC among pregnant women in this study was 151.2 μg/L [interquartile range (IQR) = 85.5–236.2 F06Dg/L], at the low end of this range. About half (49.65%) of the participants were likely to be iodine deficient. There was a significant association between having a formal job (AOR = 2.56; CI = 1.11–5.96) and iodine sufficiency. Based on a cutoff of >15 ppm (mg/kg), 91.7% (95% CI: 87.2–96.2) of the salts collected from the household had adequate iodine content. The median iodine level of the collected salt samples was 34.9 mg/kg (ppm) (IQR = 24.2–44.6 mg/kg).

Conclusions
The UNICEF 2018 guidelines for adequate iodine nutrition in pregnant women include both a recommended median range of 150–249 μg/L, and an upper limit of 20% on the fraction of the population with UIC below 50 μg/L. Because our study population’s median level is 151.2 μg/L and the percentage of pregnant women with urinary iodine concentration of less than 50 μg/L is 9.7% (14/145), the women received adequate iodine nutrition. The availability of adequately iodized salt in households is more than 90%, as recommended by WHO. In light of previous iodine deficiency in this region of Ethiopia, the salt iodization program promotes the health of babies and mothers.
Tuberculosis in individuals who recovered from COVID-19: A systematic review of case reports
Authors: Alemu Ayinalem , Bitew Zebenay Workneh , Seid Getachew , Diriba Getu , Gashu Emebet , Berhe Nega , Mariam Solomon H. , Gumi Balako 
Published: November 2022

BackgroundThe emergence of COVID-19 overwhelmed tuberculosis (TB) prevention and control, resulting in a decrease in TB detection rate and an increase in TB deaths. Furthermore, the temporary immunosuppressive effects, lung inflammation, and the corticosteroids used to treat COVID-19, may play a direct role in immunosuppression, leading to reactivation of either previous infection or latent TB or the development of new TB. Thus, the aim of this study was to review TB incidence in individuals who recovered from COVID-19.MethodsWe conducted a systematic search of available databases for previously published studies that reported TB in COVID-19 survivors. The PRISMA checklist was used to guide the review, and the JBI checklist was used to evaluate the study’s quality. The descriptive data were summarized.ResultsData were extracted from 21 studies conducted in 13 countries having 33 cases. The median age was 44 years (range; 13.5–80), and more than half (18, 54.5%) were males. Twelve patients immigrated from TB endemic settings. All 17 patients assessed for HIV were seronegative, and all 11 patients assessed for BCG vaccination status were vaccinated. The majority (20, 69%) of patients had some type of comorbidity with diabetes (12/29) and hypertension (9/29) being the most common. Four patients (30.77%) had a history of TB. Corticosteroids were used to treat COVID-19 in 62.5% (10) of individuals. Dexamethasone, remdesivir, azithromycin, hydroxychloroquine, and enoxaparin were the most commonly used drugs to treat COVID-19. The most common TB symptoms were fever, cough, weight loss, dyspnea, and fatigue. Twenty, eleven, and two patients developed pulmonary, extrapulmonary, and disseminated/miliary TB respectively. It may take up to seven months after COVID-19 recovery to develop tuberculosis. Data on the final treatment outcome was found for 24 patients, and five patients died during the anti-TB treatment period.ConclusionTuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era. The immunosuppressive nature of the disease and its treatment modalities may contribute to post COVID-19 TB. Thus, we recommend a further study with a large sample size. Furthermore, we recommend feasibility studies to assess and treat latent TB in COVID-19 patients residing in TB endemic counties since treatment of latent TB is done only in TB non-endemic countries.
Illness perspectives in patients with primary aldosteronism
Authors: Ragnarsson Oskar , Muth Andreas , Johannsson Gudmundur , Gkaniatsa Eleftheria , Ung Eva Jakobsson , Jakobsson Sofie 
Published: November 2022

Objective
The burden of symptoms and treatment in patients with primary aldosteronism (PA), as well as the patients’ experience of the health care is sparsely studied. The objectives of this study were to describe symptoms considered to be the most troublesome by patients with PA, and to explore health related worries and expectations following treatment.

Methods
This was an explorative qualitative study where 25 patients with PA, diagnosed between 2017 and 2019, were included; 13 patients who had undergone adrenalectomy and 12 who were receiving medical treatment. Data was collected during six group interviews and analyzed using a thematic approach.

Results
Three main themes were identified: 1) Distress of the past, where the most important issues were struggle to receive a correct diagnosis, impaired well-being and the consumption of a large number of tablets, 2) Satisfaction after receiving a correct diagnosis, both in patients with unilateral and bilateral disease, but also dissatisfaction with lack of information about the disease, and 3) Future concerns, where worries about the long-term effects of PA on health in general dominated.

Conclusions
Our findings illustrate several important issues related to PA where improvements in patient care are needed, including actions aiming at shortening the long diagnostic delay, a thorough information to the patients about the disease is of great importance, and that all patients with PA, regardless of treatment, would benefit from a structured long-term follow-up.
“I feel I have been taken seriously” Women’s experience of greater trochanteric pain syndrome treatment—A nested qualitative study
Authors: Andreasen Jane , Fearon Angela , Morissey Dylan , Hjørnholm Laura H. , Kristinsson Jens , Jorgensen Jens Erik , Mølgaard Carsten M. 
Published: November 2022

Background
Women experiencing greater trochanteric pain syndrome (GTPS) report high levels of pain and reduced quality of life. Exploring how they manage GTPS in a daily life context can provide important knowledge about individual coping strategies. Education, extracorporeal shockwave therapy (ESWT) and exercise have good group level evidence for efficacy in clinical trials and are increasingly used in routine care for patients with GTPS. Exploring women’s experiences of such treatment may help understand the mechanisms underpinning these positive results and inform treatment strategies. We therefore aimed to explore how women with GTPS experience and manage their daily life, and their experience of the combined treatment of education, ESWT and exercises.

Methods
This qualitative study was nested within a cohort study based in a hospital outpatient clinic and a physiotherapy clinic in Denmark assessing the combined treatment of education, ESWT and exercises. Data was collected from eleven women using in-person, individual, semi-structured interviews which were audio recorded. Transcripts were coded and analysed using an inductive thematic analysis approach.

Findings
Five themes were identified: (1) Daily life was controlled and structured by pain; (2) The condition was acknowledged and taken seriously by treating professionals; (3) The participants´ experiences of the intervention–information is key; (4) Improved capability and autonomy in pain management and (5) The women´s perspectives on improving and expanding the intervention. Learning how to manage pain was experienced as the most important element of the program to the women to be able to minimize pain and manage daily life.

Conclusion
Exploration of how women with greater trochanteric pain syndrome experienced and managed daily hip pain, and how they experienced and adapted to treatment are important novel findings that will inform clinical practice. This new knowledge may be used to inform an individualized patient education, treatment and evaluation strategy for women with the painful and debilitating condition of GTPS.
A study on the adsorption property and mechanism of β-cyclodextrin/polyvinyl alcohol/polyacrylic acid hydrogel for ciprofloxacin
Authors: Tian Jintao , Zhang Hongyu , Zhao Xinyu , Liu Wanyi , Fakhri Yasser 
Published: November 2022

Abstract
Polyvinyl alcohol (PVA), acrylic acid (AA), and β-cyclodextrin (β-CD) were used as monomers, and ammonium persulfate was used as an initiator. Orthogonal tests were optimized the experimental condition, and aqueous polymerization was used to prepare poly-β-cyclodextrin/polyvinyl alcohol/polyacrylic acid (β-CD/PVA/PAA) hydrogel. The samples were characterized by FT-IR (Fourier transform infrared), SEM (Scanning electron microscopy), and XRD (X-ray diffraction). β-CD/PVA/PAA hydrogel was analyzed, which influenced external environmental factors on the β-CD/PVA/PAA hydrogel adsorption performance, and the kinetic behavior of β-CD/PVA/PAA hydrogel on ciprofloxacin (CIP) adsorption was explored. The results concluded that the prepared β-CD/PVA/PAA hydrogel has a well-defined three-dimensional network structure. The decrease in the pH of the CIP solution and the adsorption temperature reduces the adsorption reaction of β-CD/PVA/PAA hydrogel on CIP. The kinetics of CIP adsorption by β-CD/PVA/PAA hydrogel confirmed the pseudo-second-order kinetic model (R
2 > 0.997), the maximum equilibrium adsorption amounts is 372.12 mg/g, the removal rate reaches 74.42%. The adsorption process was mainly chemisorption, the adsorption isotherm fits the Freundlich adsorption isotherm model (R
2 > 0.946), and the adsorption process was heterogeneous with multi-molecular layer adsorption. The adsorption process inclined more toward the adsorption of inhomogeneous multi-molecular layers. The β-CD/PVA/PAA hydrogel retained 80% adsorption properties after three adsorption-desorption under optimal conditions.
EDM-GNSS distance comparison at the EURO5000 calibration baseline: preliminary results
Authors: Wezka Kinga , García-Asenjo Luis , Próchniewicz Dominik , Baselga Sergio , Szpunar Ryszard , Garrigues Pascual , Walo Janusz , Luján Raquel 
Published: November 2022

Abstract
At the Pieniny Klippen Belt in Poland, the novel primary reference baseline EURO5000 is required as part of the European Research project GeoMetre to both validate refractivity-compensated EDM prototypes and investigate the metrological traceability of GNSS-based distances. Since the aimed uncertainty is 1 mm at 5 km (k = 2), the design, construction, and validation must be carefully prepared to fulfil the high standards of the GeoMetre field campaigns which are planned to be carried out in May 2022. This contribution describes the main features of the EURO5000 and presents the results of the preliminary validation which includes a first comparison between the results obtained by using precise currently available EDMs as well as GNSS techniques following the standard GNSS geodetic processing algorithms, on the one hand, and the improved GNSS-Based Distance Meter (GBDM+) approach developed at UPV, on the other hand. The preliminary validation presented in this contribution also permits (1) to detect potential problems in the use of the baseline such as potential geodynamic problems, atmospheric refraction or multipath limitations, (2) to produce a set of reliable results, and (3) to pave the way for the final field comparisons between the novel EDMs and the GBDM+ approach. The result of this metrological experiment may significantly contribute to overcome the limitations of current high-precision deformation monitoring applications that require their scale to be consistent with the SI-metre within 0.1 ppm in several km.
Examination of α′′, α′ and ω phases in a β-type titanium–niobium metal
Authors: Sun Jin-hui 
Published: November 2022

Abstract
In this study, titanium–niobium (Ti-Nb) alloy samples containing β, α′′, ω and α′ were used to investigate the effect of each phase on the mechanical properties. The results show that the content of each phase affects the shape of the tensile curve. When the fraction of ω phase is relatively large, the tensile curve exhibits obvious upper yield point and lower yield point. However, the fraction of α′′ phase is relatively large; the tensile curve has a single peak yield stage. A small amount of α′ phase can significantly improve the yield strength, however, the elongation decreased significantly. In addition, some ω phase surrounded in α′′ matrix was also observed, and it can be inferred that the micro-crack may first appear at the incoherent ω/α′′ interface under the application of external stress.
Influence of acidic media and chlorides on protective properties of epoxy coatings
Authors: Alar Vesna , Stojanović Ivan , Šimunović Vinko , Kurtela Marin , Samardžija Marina , Ivaniš Dalibor 
Published: November 2022

AbstractOrganic coatings are used as one of the key surface protection methods to protect cast iron pipelines against corrosion due to their cost efficiency and a variety of applications. In most metallic systems that are protected by organic coatings, the performance depends on the response of the coating to corrosion stresses to which they are exposed during operation. One of the most dangerous factors causing chemical damage to coatings are the acidic and chloride aggressive media. Such damage reduces the protection effectiveness thus leading to blistering, cracking, increase in pore volume and number, as well as loss of adhesion. Moreover, the influence of aggressive media impairs also aesthetic characteristics. In the experimental part of the paper, analyses of the physical and chemical properties of epoxy coatings applied on the metal substrate in phosphoric acid, acetic acid and 3.5 wt% NaCl solutions were carried out. The test results showed that the physical properties of epoxy coatings were satisfactory in the acidic medium, but electrochemical tests in 3.5 wt% NaCl solution showed reduced corrosion protection.
Friction stir welding for manufacturing of a light weight combat aircraft structure
Authors: Rajendran Chinnasamy , Srinivasan Kasi , Balasubramanian Visvalingam , Sonar Tushar , Balaji Haridasu 
Published: November 2022

Abstract
This paper aims to validate the viability of friction stir welding process (FSW) to join high strength aerospace grade AA2014-T6 aluminium alloy for manufacturing light-weight combat aircraft (LCA) structure as a replacement to riveting process. FSW is used to overcome the heat input-related problems in fusion welding of AA2014-T6 aluminium alloy such as coarse grain fusion zone microstructure, softening in HAZ and lower joint efficiency. The 2 mm thick AA2014-T6 aluminium alloy sheets were used as the base material (BM). Friction stir butt (FBW) and friction stir lap (FLP) joints were developed, and its performance was compared with double cover riveted butt (DRB) joint in butt (RBJ) and lap (RLJ) joint configuration. Results showed that the load-carrying capability of FSW joints is greater than the riveted joints. The superior load-carrying capacities of FBW and FLW joints refers to evolution of refined grains and strengthening precipitates in stirred zone (SZ), which ensures superior metallurgical bonding between the joining surfaces. The riveted joints disclosed inferior load-carrying capacities due to the lack of metallurgical connection between the joining surfaces.