bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men
Authors: Abdulla Haitham , Phillips Bethan , Wilkinson Daniel , Gates Amanda , Limb Marie , Jandova Tereza , Bass Joseph , Lewis Johnathan , Williams John , Smith Kenneth , Idris Iskandar , Atherton Philip 
Published: October 2022

AbstractIntroductionAgeing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypothesized exogenous GLP-1 infusions would enhance muscle perfusion and positively affect glucose metabolism during fed-state clamps in older people.MethodsEight men (71 ± 1 years) were studied in a randomized crossover trial. Basal blood samples were taken before postprandial (fed-state) insulin and glucose clamps, accompanied by amino acid infusions, for 3 hours. Reflecting this, following insertions of peripheral and femoral vessels cannulae and baseline measurements, peripheral IV infusions of octreotide, insulin (Actrapid), 20% glucose, and mixed amino acids; Vamin 14-EF with or without a femoral arterial GLP-1 infusion were started. GLP-1, insulin, and C-peptide were measured by ELISA. Muscle microvascular blood flow was assessed via contrast enhanced ultrasound. Whole-body glucose handling was assayed by assessing glucose infusion rate parameters.ResultsSkeletal muscle microvascular blood flow significantly increased in response to GLP-1 vs feeding alone (5.0 ± 2.1 vs 1.9 ± 0.7 fold-change from basal, respectively; P = 0.008), while also increasing whole-body glucose uptake (area under the curve 16.9 ± 1.7 vs 11.4 ± 1.8 mg/kg−1/180 minutes−1, P = 0.02 ± GLP, respectively).ConclusionsThe beneficial effects of GLP-1 on whole-body glycemic control are evident with insulin clamped at fed-state levels. GLP-1 further enhances the effects of insulin on whole-body glucose uptake in older men, underlining its role as a therapeutic target. The effects of GLP-1 in enhancing microvascular flow likely also affects other glucose-regulatory organs, reflected by greater whole-body glucose uptake.
Meeting report – Cell size and growth: from single cells to the tree of life
Authors: Chatzitheodoridou Dimitra , D'Ario Marco , Jones Ian , Piñeros Liliana , Serbanescu Diana , O'Donnell Frank , Cadart Clotilde , Swaffer Matthew P. 
Published: October 2022

ABSTRACT
In April 2022, The Company of Biologists hosted their first post-pandemic in-person Workshop at Buxted Park Country House in the Sussex countryside. The Workshop, entitled ‘Cell size and growth: from single cells to the tree of life’, gathered a small group of early-career and senior researchers with expertise in cell size spanning a broad range of organisms, including bacteria, yeast, animal cells, embryos and plants, and working in fields from cell biology to ecology and evolutionary biology. The programme made ample room for fruitful discussions and provided a much-needed opportunity to discuss the most recent findings relating to the regulation of cell size and growth, identify the emerging challenges for the field, and build a community after the pandemic.
Closing the Gender Profit Gap?
Authors: Batista Catia , Sequeira Sandra , Vicente Pedro C. 
Published: October 2022

We examine the impact of providing access to mobile savings accounts and improving financial management skills on the performance of microenterprises in Mozambique. The effects are highly heterogeneous: Combining both types of support is associated with a large increase in both short- and long-term firm profits and in financial security for female microentrepreneurs. This allowed female-headed microenterprises, particularly those with a higher level of profits at baseline, to close the gender profit gap in performance and skills relative to their male counterparts. The main drivers of improved business performance are improved financial management practices (bookkeeping), an increase in accessible savings, and reduced transfers to friends and relatives. Providing access to mobile money as a tool to save and manage finances also increases long-term profits of female microentrepreneurs, particularly for those with higher profits at baseline. However, neither treatment has any impact on male-led enterprises. Uncovering this heterogeneity in impact across different types of microenterprises can help improve the targeting of these interventions in the future. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: This work was supported by the International Growth Centre and the U.S. Agency for International Development [Grant AIO-OAA-F-12-00015]. Supplemental Material: The data files and Online Appendix are available at https://doi.org/10.1287/mnsc.2022.4579 .
Gaiola em decomposição, a história do Edifício São Pedro
Authors: Araújo Alessandra Oliveira , Alves Virna Maria Benevides 
Published: October 2022

O presente artigo é resultado de pesquisa bibliográfica, documental e de campo sobre o Edifício São Pedro, primeiro prédio com mais de três andares construído na orla de Fortaleza. Iniciamos com uma contextualização histórica do período conhecido como Belle Époque de Fortaleza, usando Ponte (2000) como principal referência. Depois, descreveremos a história do Edifício, desde sua inauguração até o momento de realização da pesquisa, para nos embasar, usamos Jucá (2000), Ponte (2000), Berman (2007), além de documentos do Arquivo Nirez, matérias de jornais locais e documentário produzido sobre o prédio. Por fim, apresentamos uma etapa da pesquisa de campo em que fomos ao prédio e conhecemos seus espaços internos, objetos deixados pelos últimos moradores e vimos a situação em que o prédio se encontra. Ao final, refletimos sobre o processo de construção e demolição citadino e o quanto esse movimento pode prejudicar a construção da memória e sentimento de pertença na cidade.
O verbo em Giovanni Verga: considerações sobre o uso dos tempos e dos modos e os desafios para a tradução
Authors: Arêas Alcebíades Martins , Santos Maria Aparecida Cardoso , Belizário Edvaldo Sampaio 
Published: October 2022

RESUMO: O presente trabalho tem por objetivo apresentar a tradução de fragmentos retirados de alguns contos escritos por Giovanni Verga com foco na tradução para o português de alguns tempos e modos verbais do italiano. Nossa estratégia de tradução obedece ao escopo de buscar a melhor forma e o melhor conteúdo privilegiando a clareza e o sentido dos textos escolhidos para a língua portuguesa e partindo, sempre que possível e necessário, de uma perspectiva comparatista em que a tradução para outras línguas pode corroborar nossas escolhas.Palavras-chave: Giovanni Verga. Tempo Verbal. Modo Verbal. Tradução. ABSTRACT: Il presente lavoro si propone di presentare la traduzione di frammenti tratti da alcuni racconti scritti da Giovanni Verga, concentrandosi sulla traduzione in portoghese di alcuni tempi e modi verbali italiani. La nostra strategia di traduzione segue lo scopo di ricercare la migliore forma ed il miglior contenuto, dando priorità alla chiarezza e al significato dei testi scelti per la lingua portoghese e partendo, ove possibile e necessario, da una prospettiva comparativa in cui la traduzione in altre lingue può confermare le nostre scelte.Parole chiave: Giovanni Verga. Tempo Verbale. Modo Verbale. Traduzione. ABSTRACT: The present work aims to present the translation of fragments taken from some short stories written by Giovanni Verga, focusing on the translation into Portuguese of some Italian verbal tenses and modes. Our translation strategy follows the scope of seeking the best form and the best content, prioritizing the clarity and meaning of the texts chosen for the Portuguese language and departing, whenever possible and necessary, from a comparative perspective in which the translation into other languages can corroborate our choices.Keywords: Giovanni Verga. Verbal Tense. Verbal Mode. Translation.
A cost–consequence analysis of eLearning videos designed to supplement the consent process in lower limb arthroplasty
Authors: Brock J , Sale A , Jayaraju U , Chandetreya A , Lee P 
Published: October 2022

Introduction Since the Montgomery ruling in 2015 surgeons have been tasked with identifying material risk when taking informed consent. Despite this, there has been limited uptake of technological aids to supplement the consent process although such aids are shown to improve patient knowledge and satisfaction. ConsentPLUS is a free-to-access website with bite-sized educational videos designed to clearly explain lower limb arthroplasty procedures to patients and aid their consent. Methods The authors performed a prospective cost–consequence analysis, outlining any costs associated with the intervention and any quantitative or qualitative impacts the intervention may have on patients. Results A total of 3,143 consecutive patients were identified who were undergoing total knee or hip replacement in 25 elective NHS orthopaedic units. The total cost of development and projected 10-year running fees for ConsentPLUS total £75,000. Health Foundation support means the service is free-to-access for centres throughout the UK. Mean exposure time per patient was 10min 29s, equivalent to £185,437 of additional contact time according to the National Tariff. Mean clinic time was reduced by 17min owing to the earlier identification of material risk. Patient knowledge on pre- and post-video quizzes increased from 7.01 to 9.08 following eLearning (paired t-test = 0.998). The process had an overall satisfaction rate of 97%. Conclusion Educational eLearning videos are an accessible and digestible way to supplement the consent process. This enables earlier identification of material risk in clinics owing to improved patient knowledge, leading to increased patient satisfaction with arthroplasty consenting.
Outpatient secondary care pathways for head and neck cancer referral result in patient delays for cancer treatment
Authors: Chakravarty PD , Ton T , Scott A , Doherty C , Douglas CM , Montgomery J 
Published: October 2022

Introduction The majority of head and neck cancer referrals are received through primary care. A proportion of cancer referrals are received through secondary care specialties. Local delivery plan (LDP) targets in Scotland for cancer investigation are set at 31 days for diagnosis and 62 days to start treatment. The aim was to audit referrals made through non-primary care pathways compared with the standard primary care pathways against LDP targets. Methods New head and neck cancer patients between 1 January 2014 and 1 January 2019 were included. Pathway points were recorded between referral to outpatient clinic, time to multidisciplinary team discussion (MDT) and finally MDT to treatment. Results 1,276 new patient referrals were received over a 5-year period. Of these, 136 (10%) were referred via non-primary care pathways. The mean time for urgent suspicion of cancer (USoC) referrals to start treatment was 77 days (15 days over target) and for outpatient secondary care referrals was 102 days (40 days over target) (p<0.05). When treatment intent was considered, 841/1,131 (75%) of patients referred via primary care were treated curatively compared with 49/99 (49%) (p<0.05) of patients referred through the secondary outpatient pathway. Conclusion Patients with head and neck cancer referred from other outpatient specialties face delays commencing cancer treatment and are also associated with a greater likelihood of being treated with palliative intent.
Evaluating diagnostic accuracies of Panbio™ test and RT-PCR for the detection of SARS-CoV-2 in Addis Ababa, Ethiopia using Bayesian Latent-Class Models (BLCM)
Authors: Sisay Abay , Hartnack Sonja , Tiruneh Abebaw , Desalegn Yasin , Tesfaye Abraham , Desta Adey Feleke 
Published: October 2022

BackgroundRapid diagnostics are vital for curving the transmission and control of the COVID-19 pandemic. Although many commercially available antigen-based rapid diagnostic tests (Ag-RDTs) for the detection of SARS-CoV-2 are recommended by the WHO, their diagnostic performance has not yet been assessed in Ethiopia. So far, the vast majority of studies assessing diagnostic accuracies of rapid antigen tests considered RT-PCR as a reference standard, which inevitably leads to bias when RT-PCR is not 100% sensitive and specific. Thus, this study aimed to evaluate the diagnostic performance of Panbio™jointly with the RT-PCR for the detection of SARS-CoV-2.MethodsA prospective cross-sectional study was done from July to September 2021 in Addis Ababa, Ethiopia, during the third wave of the pandemic involving two health centers and two hospitals. Diagnostic sensitivity and specificity of Panbio™and RT-PCR were obtained using Bayesian Latent-Class Models (BLCM).Results438 COVID-19 presumptive clients were enrolled, 239 (54.6%) were females, of whom 196 (44.7%) had a positive RT-PCR and 158 (36.1%) were Panbio™positive. The Panbio™and RT-PCR had a sensitivity (95% CrI) of 99.6 (98.4–100) %, 89.3 (83.2–97.6) % and specificity (95% CrI) of 93.4 (82.3–100) %, and 99.1 (97.5–100) %, respectively. Most of the study participants, 318 (72.6%) exhibited COVID-19 symptoms; the most reported was cough 191 (43.6%).ConclusionAs expected the RT-PCR performed very well with a near-perfect specificity and a high, but not perfect sensitivity. The diagnostic performance of Panbio™is coherent with the WHO established criteria of having a sensitivity ≥80% for Ag-RDTs. Both tests displayed high diagnostic accuracies in patients with and without symptoms. Hence, we recommend the use of the Panbio™for both symptomatic and asymptomatic individuals in clinical settings for screening purposes.
Experiences from COVID-19-driven use of telephone consultations in a cardiology clinic—The CoviTel study
Authors: Hundebøll Astrid Brink , Rosenstrøm Stine , Jensen Magnus Thorsten , Dixen Ulrik 
Published: October 2022

Introduction
The COVID-19 pandemic triggered a rapid shift towards telephone consultations (TC) in the out-patient clinic setting with little knowledge of the consequences. The aims of this study were to evaluate patient-centred experiences with TC, to describe patterns in clinical outcomes from TC and to pinpoint benefits and drawbacks associated with this type of consultations.

Methods
This mixed methods study combined an analysis of quantitative and qualitative data. A quantitative, retrospective observational study was conducted employing data from all 248 patients who received TC at an out-patient cardiology clinic during April 2020 with a one-month follow-up. Semi-structured interviews were conducted; Ten eligible patients were recruited from the outpatient clinic by purposive sampling.

Results
Within the follow-up period, no patients died or were acutely hospitalised. Approximately one in every four patients was transferred to their general practitioner, while the remaining three-quarter of the patients had a new examination or a new consultation planned. The cardiologist failed to establish contact with more than a fifth of the patients, often due to missing phone numbers. Ten patients were interviewed. Five themes emerged from the interviews: 1) Knowing an estimated time of the consultation is essential for patient satisfaction, 2) TC are well perceived when individually adapted, 3) TC can be a barrier to patient questions, 4) Video consultations should only be offered to patients who request it, and 5) Prescriptions or instructions made via TC do not cause uncertainty in patients.

Conclusions
The TC program was overall safe and the patients felt comfortable. Crucial issues include precise time planning, the patient’s availability on the phone and a correct phone number. Patients stressed that TC are unsuitable when addressing sensitive topics. A proposed visitation tool is presented.
METODOLOGIA DE ANÁLISE E AÇÃO NAS INTERVENÇÕES URBANAS NO BAIRRO REBOUÇAS EM CURITIBA-PR
Authors: Dos Santos Maria da Graça Rodrigues , C. de Freitas-Firkowski Olga Lucia 
Published: October 2022

Este artigo tem por objetivo apresentar uma metodologia de análise das intervenções urbanas que vêm ocorrendo em parte do Bairro Rebouças, em Curitiba, e, para alcançá-lo, aponta para ações que, associadas ao desenvolvimento urbano, possibilitem a preservação do seu antigo núcleo industrial-ferroviário. Faz-se, portanto, uso de diferentes elementos interpretativos - da geografia, da arquitetura e urbanismo, da sociologia e da história - sem perder o rigor na utilização dos conceitos de referência nas análises. A definição clara das terminologias que caracterizam as intervenções e a análise por escalas, adotada no desenvolvimento do método, revela o jogo de interesses de agentes públicos e privados, produtores do espaço urbano; as mudanças que a lei induz; e seus reflexos no espaço real. As análises são acompanhadas de mapas resultantes de levantamentos in loco e pesquisa documental, que compõem um diagnóstico, permitindo estabelecer critérios para preservação, sem comprometer o desenvolvimento urbano.
Health Outcomes, Income and Income Inequality: Revisiting the Empirical Relationship
Authors: Alexiou Constantinos , Trachanas Emmanouil 
Published: October 2022

Abstract
In this paper we revisit the relationship between health outcomes, income, and income inequality by applying alternative panel methodologies to a dataset of high-income countries spanning the time period 1980–2017. In this direction, we adopt alternative methodological frameworks in order to provide a) meaningful results by taking into account standard errors that alleviate problems of cross-sectional (spatial) and temporal dependence, and b) insights into the underlying relationships at several points of the conditional distribution of the health outcomes dependent variables. The evidence strongly supports the significant role that income plays in determining health outcomes. The findings relating to income inequality and nonlinear terms are more fragmented in that their significance and sign-direction depend on the functional form and the respective quantiles of the distribution the relationships are evaluated.
Open Educational Resources-Praxis an Hochschulen
Authors: Warkentin Charlotte 
Published: October 2022

Zusammenfassung
Der pandemiebedingte Digitalisierungsschub der Hochschullehre ermöglicht, das Potential von Open Educational Resources (OER) noch stärker zu erkennen und zu nutzen. In diesem Artikel werden anhand einer Literaturanalyse ermittelte relevante Kompetenzen für die OER-Praxis beschrieben. Mit dem Ziel, einen Workflow zu entwickeln, der Lehrende im Umgang mit OER lokal unterstützt, wurde exemplarisch die aktuelle OER-Praxis an der Fachhochschule Potsdam mit einer Sekundäranalyse von Umfragedaten untersucht und bestehende hochschulinterne Serviceeinrichtungen identifiziert, deren Angebote auch OER-spezifische Kompetenzen abdecken. Grundlage des Artikels bildet die Bachelorarbeit mit demselben Titel, die im Wintersemester 21/22 von der Autorin an der Fachhochschule Potsdam unter der Betreuung von Frau Prof. Dr. jur. Ellen Euler und Gabriele Fahrenkrog im Studiengang Bibliothekswissenschaft entstanden ist.
Quantifying the importance of morphomic structure, semantic values, and frequency of use in Romance stem alternations
Authors: Herce Borja 
Published: October 2022

AbstractStem alternations in Romance have recently been argued to be regulated largely by autonomously morphological (aka morphomic) organizational principles. Here, I assess the relative contribution of morphomic structures vis à vis alternative principles, namely semantic structure, and token frequency. Results confirm the exceptional importance of autonomously morphological domains on Romance verb stem alternations; however, inherent inflectional values and token frequency also play a decisive role in the overall stem-morphological similarity of different paradigm cells.
‘Leftover women’: A sociolinguistic study of gender bias in Chinese
Authors: He Lin , Chen Rong , Dong Ming 
Published: October 2022

Abstract
This study is an investigation of a newly-created Chinese lexeme shengnü ‘leftover women’, referring to single women beyond the socially expected marrying age. Data from an online survey of 416 respondents reveals the various aspects of gender bias against women as seen in the coined term. They also provide evidence that gender bias is waning, as younger and female respondents are more likely to view shengnü as more offensive, to see the reasons for being ‘leftover’ as women’s desire for independence and freedom, and to identify society as the source of pressure for women to marry. Our study contributes to the field of sociolinguistics via its investigation of shengnü with other aspects of the Chinese language, by adopting a social media survey data gathering method – which offered us a sizable sample – and by being possibly the first empirical sociolinguistic study of gender bias via a detailed investigation of the various aspects of a particular lexeme in the Chinese language.
The Curious Case of Ditransitive Pity, or the Productivity of an Unproductive Pattern
Authors: Colleman Timothy 
Published: October 2022

Abstract
This article starts out from the observation that, in present-day English, pity is occasionally used in the ditransitive [Subj V Obj1 Obj2] argument structure pattern, although the verb denotes an emotional state and can hardly be construed as encoding an event by means of which a transfer of possession is potentially brought about. Since the English ditransitive construction is undergoing a semantic specialization process, one hypothesis that comes directly to mind is that the sporadic uses of ditransitive pity are a relic from a formerly more well-entrenched use. Data from the CLMET 3.1 corpus and from COHA suggest that this scenario is unlikely, though. Instead, it will be argued that ditransitive pity – as well as uses with other emotion verbs such as rue and resent – are low-level extensions starting from the verb-specific [Subj envy Obj1 Obj2] pattern, which is thus less unproductive as has been assumed in the existing literature.
Additive Manufacturing—Nondestructive Testing—Intentionally Seeding Flaws in Metallic Parts
Authors:   ASTM International
Published: October 2022

Description
This document provides information for intentionally seeding flaws in additively manufactured parts and complements ISO/ASTM TR 52905.* The different additive manufacturing (AM) building descriptions can be found readily in published standards (see ISO 17296-2) and scientific papers. Jargon commonly used in the literature describing AM metal process defects includes “balling,” “fireworks,” and “smoke,” which often are not specific to the morphology of the defect and result from widely differing mechanisms of formation. When defining terms specific to AM metal flaws, it may be useful to review some examples related to welding technology.