bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volume‐Outcome Relationships for Percutaneous Coronary Intervention in Acute Myocardial Infarction
Authors: Saito Yuichi , Tateishi Kazuya , Kanda Masato , Shiko Yuki , Kawasaki Yohei , Kobayashi Yoshio , Inoue Takahiro 
Published: March 2022

Background
Lower primary percutaneous coronary intervention (PCI) volume is known to be associated with worse outcomes in patients with acute myocardial infarction (MI) at hospital level. The present study aimed to evaluate the relations of primary, elective, and total PCI volume and primary/total PCI volume ratio per hospital to in‐hospital mortality in patients with acute MI undergoing primary PCI.

Methods and Results
Using a large nationwide administrative database, we included a total of 83 076 patients from 154 hospitals in Japan undergoing PCI for either acute MI or elective cases. Relations of annual procedural volumes for primary, elective, and total PCI to in‐hospital mortality after acute MI at hospital level were evaluated. The ratio of primary to total PCI volume per hospital was also assessed. The primary end point was the ratio of observed to predicted mortality. Of 83 076 patients, 26 913 (32.4%) underwent primary PCI for acute MI, among whom 1561 (5.8%) died during hospitalization. Overall, observed in‐hospital mortality after acute MI and observed/predicted mortality ratio were higher in hospitals with lower primary, elective, and total PCI volumes. Observed/predicted in‐hospital mortality ratio was higher in hospitals with low primary/total PCI volume ratio, even in those with high total PCI volume.

Conclusions
Primary, elective, and total PCI volume at hospitals were inversely associated with in‐hospital mortality in patients with acute MI undergoing primary PCI. Lower ratio of primary to total PCI volume were related to higher in‐hospital mortality, suggesting primary/total PCI volume ratio as an institutional indicator of quality of care for acute MI.
Atrial Structural Remodeling in Patients With Atrial Fibrillation Is a Diffuse Fibrotic Process: Evidence From High‐Density Voltage Mapping and Atrial Biopsy
Authors: Yamaguchi Takanori , Otsubo Toyokazu , Takahashi Yuya , Nakashima Kana , Fukui Akira , Hirota Kei , Ishii Yumi , Shinzato Kodai , Osako Ryosuke , Tahara Mai , Kawano Yuki , Kawaguchi Atsushi , Aishima Shinichi , Takahashi Naohiko , Node Koichi 
Published: March 2022

Background
Low‐voltage areas (LVAs) in the atria of patients with atrial fibrillation are considered local fibrosis. We hypothesized that voltage reduction in the atria is a diffuse process associated with fibrosis and that the presence of LVAs reflects a global voltage reduction.

Methods and Results

We examined 140 patients with atrial fibrillation and 13 patients with a left accessory pathway (controls). High‐density bipolar voltage mapping was performed using a grid‐mapping catheter during high right atrial pacing. Global left atrial (LA) voltage (V
GLA
) in the whole LA and regional LA voltage (V
RLA
) in 6 anatomic regions were evaluated with the mean of the highest voltage at a sampling density of 1 cm
2
. Patients with atrial fibrillation were categorized into quartiles by V
GLA
. LVAs were evaluated at voltage cutoffs of 0.1, 0.5, 1.0, and 1.5 mV. Twenty‐eight patients with atrial fibrillation also underwent right atrial septum biopsy, and the fibrosis extent was quantified. Voltage at the biopsy site (V
biopsy
) was recorded. V
GLA
results by category were Q1 (<4.2 mV), Q2 (4.2–5.6 mV), Q3 (5.7–7.0 mV), and Q4 (≥7.1 mV). V
RLA
at any region was reduced as V
GLA
decreased. V
GLA
and V
RLA
did not differ between Q4 and controls. The presence of LVAs increased as V
GLA
decreased at any voltage cutoff. Biopsies revealed 11±6% fibrosis, which was inversely correlated with both V
biopsy
and V
GLA
(
r
=–0.71 and –0.72, respectively). V
biopsy
was correlated with V
GLA
(
r
=0.82).

Conclusions
Voltage reduction in the LA is a diffuse process associated with fibrosis. Presence of LVAs reflects diffuse voltage reduction of the LA.
Endangered Blue Whale Survival in the North Atlantic: Lagging Scientific and Governance Responses, Charting Future Courses
Authors: Koubrak Olga , VanderZwaag David L. , Worm Boris 
Published: March 2022

Abstract
Populations of blue whales were heavily depleted across the globe by industrial whaling and are still considered globally endangered today. In the Northwest Atlantic, an estimated 400–600 individuals remain, but these numbers are highly uncertain. Ship strikes, fishing gear entanglement, and marine debris are thought to be leading causes of contemporary human-caused mortality in blue whales, with anthropogenic noise possibly causing sublethal stress and injury. Climate change is recognised as an emerging and intensifying threat that is likely to affect food supply and could limit the capacity of the population to recover. Both Canada and the United States have protected blue whales through their domestic legislation. This article reviews law and policy responses in the two countries, as well as bilateral, regional and international frameworks that address anthropogenic threats to blue whales. Future scientific directions, as well as recommendations for improvements to domestic legislation and multilevel cooperation are outlined.
Pierre Bayle’s Erasmus
Authors: Regier Willis Goth 
Published: March 2022

Abstract
Desiderius Erasmus (1466?-1536) and Pierre Bayle (1647–1706) are two of the most respected figures in the Republic of Letters. Their names are often joined due to similarities in their thinking and concerns, their ties to Rotterdam, their coincidental circumstances, and Bayle’s own praise of Erasmus. Bayle read Erasmus carefully, quoted him often, cited him more often still, and noted his flaws. This paper tracks Bayle’s explicit references to Erasmus in his journalism, books, and letters. It indicates what he read and what he apparently preferred among Erasmus’ writings. It observes Bayle’s rare ensemble of Erasmian affinities, his contributions to Erasmus scholarship, and his uses of Erasmus in his own work.
Ettore Romagnoli traduttore delle Baccanti
Authors: Troiani Sara 
Published: March 2022

Abstract
At the beginning of the Twentieth Century the Italian philologist Ettore Romagnoli popularised ancient classical culture through his work as translator and director of performances of Greek and Roman dramas. In his plays he attempted to reproduce the unity of the arts that belonged to the mousikē technē and to achieve a modern recreation of ancient sounds and rhythms. The paper aims to analyse the translation of Euripides’ Bacchae by Romagnoli (1912), comparing it with his studies on Greek music and tragedy and with operas. On the one hand, Romagnoli’s translation in Italian verses is based on the musicological theories about the close relationship between music and metrics in ancient Greek poetry; on the other, the adoption of operatic language to translate specific lines of Euripides’ drama is probably oriented to the Italian audience, which would have recognised conventional expressions from the libretti or from famous arias.
Two Auloi from Megara
Authors: Terzḗs Chrḗstos , Hagel Stefan 
Published: March 2022

Abstract
Two aulos pairs (Δ1965 and Δ1964), unearthed in 1980 and 2005 respectively at Megara (Attica), are exhibited in the city’s Archaeological Museum. Both are associated with metal sliding keys (resembling the keys on the well-known Pergamon aulos model), either mounted on the pipes (Δ1964) or displayed next to them (Δ1965). The present paper describes the parts, proposes a meaningful re-assemblage of the bone sections, and gives a detailed account of the sliding mechanism, which is here for the first time attested on finds of actual musical instruments, including an entirely new technology of speaker hole keys. A musical analysis, based on determining plausible reed configurations using software modelling, suggests that the finds represent a partially standardised design of professional modulating auloi, playing attested harmoníai while hovering between the enharmonic and chromatic.
Re-Stringing the Daphnē Harp?
Authors: Hagel Stefan 
Published: March 2022

Abstract
D. Najock has criticised a tentatively proposed diatonic-chromatic tuning for the triangular frame harp found at Daphnē and suggested a different enharmonic-diatonic stringing. While his criticism may well be justified, it is argued that his alternative proposal is physically problematic and historically implausible. A possible compromise is discussed.
Ancient ‘Solmisation’ and the Meaning of Notes
Authors: Hagel Stefan 
Published: March 2022

Abstract
When contextualising the ancient Greek solmisation system, known from Aristides Quintilianus and one of Bellermann’s Anonymi, within its musical and linguistic environment, it emerges that it hardly predates the Roman Imperial period, an important part of whose musical schooling it appears to have formed. The system seems based on a combination of the various vowels’ intrinsic F2 pitch and intensity and reflects the harmonic hierarchies of contemporary music, shedding a much more favourable light on the music-psychological relevance of Aristides’ gendered musical notes than is conventionally assumed.
Phylum Nematoda: trends in species descriptions, the documentation of diversity, systematics, and the species concept
Authors: HODDA M. 
Published: March 2022

This paper summarizes the trends in nematode species description and systematics emerging from a comparison of the latest comprehensive classification and census of Phylum Nematoda (Hodda 2022a, b) with earlier classifications (listed in Hodda 2007). It also offers some general observations on trends in nematode systematics emerging from the review of the voluminous literature used to produce the classification. The trends in nematodes can be compared with developments in the systematics of other organisms to shed light on many of the general issues confronting systematists now and into the future.
The Time-Dependent Response of a Two-Basin Ocean to a Sudden Surface Temperature Change
Authors: Chang Chiung-Yin , Jansen Malte F. 
Published: March 2022

Abstract
Building on previous work using single-basin models, we here explore the time-dependent response of the Atlantic meridional overturning circulation (AMOC) to a sudden global temperature change in a two-basin ocean–ice model. We find that the previously identified mechanisms remain qualitatively useful to explain the transient and the long-term time-mean responses of the AMOC in our simulations. Specifically, we find an initial weakening of the AMOC in response to warming (and vice versa for cooling), controlled by the mid-depth meridional temperature contrast across the Atlantic basin. The long-term mean response instead is controlled primarily by changes in the abyssal stratification within the basin. In contrast to previous studies we find that for small-amplitude surface temperature changes, the equilibrium AMOC is almost unchanged, as the abyssal stratification remains similar due to a substantial compensation between the effects of salinity and temperature changes. The temperature-driven stratification change results from the differential warming/cooling between North Atlantic Deep Water and Antarctic Bottom Water, while the salinity change is driven by changes in Antarctic sea ice formation. Another distinct feature of our simulations is the emergence of AMOC variability in the much colder and much warmer climates. We discuss how this variability is related to variations in deep-ocean heat content, surface salinity, and sea ice in the deep convective regions, both in the North Atlantic and in the Southern Ocean, and its potential relevance to past and future climates.
Distal radial artery as an alternative approach to forearm radial artery for perioperative blood pressure monitoring: a randomized, controlled, noninferiority trial
Authors: Xiong Jingwei , Hui Kangli , Xu Miaomiao , Zhou Jiejie , Zhang Jie , Duan Manlin 
Published: March 2022

Abstract
Background
The novel distal radial artery (dRA) approach is a popular arterial access route for interventional cardiology and neurointerventions. We explored the dRA as an alternative site to the classic forearm radial artery (RA) for perioperative blood pressure monitoring. We hypothesized that dRA catheterization is noninferior to RA for the first attempt success rate.

Methods
This was a single-center, prospective, randomized controlled, noninferiority study. Adult patients who underwent elective surgery at the Jinling Hospital from May 2021 to August 2021 were enrolled. The primary endpoint was to test the noninferiority of the first attempt success rate between the groups. Secondary endpoints included anatomical characteristics, catheterization time, arterial posterior wall puncture rate, postoperative compression time, dampened arterial pressure waveforms, and complications.

Results
Totally, 161 patients who received either dRA (n = 81) or RA (n = 80) catheterization were analyzed. The first attempt success rates were 87.7 and 91.3% in the dRA and RA groups, respectively, with a mean difference of − 3.6% (95% CI, − 13.1 to 5.9%). The dRA diameter and cross-sectional area were significantly smaller than those of the RA (P < 0.001). The subcutaneous depth of dRA was significantly greater than that of the RA (P < 0.001). The dRA had a longer catheterization time (P = 0.008) but a shorter postoperative compression time (P < 0.001). The arterial posterior wall puncture rate of dRA was significantly higher than that of the RA (P = 0.006). The dRA had fewer dampened arterial waveforms than RA (P = 0.030) perioperatively.

Conclusions
The dRA is a rational alternative approach to RA for perioperative arterial pressure monitoring and provides a noninferior first attempt success rate.

Trial registration
This study is registered in the Chinese Clinical Trials Registry (registration number: ChiCTR2100043714, registration date: 27/02/2021).
Lived experiences of Palestinian patients with COVID-19: a multi-center descriptive phenomenological study of recovery journey
Authors: Alkaissi Aidah , Zaben Fadi , Abu-Rajab Mohammad , Alkony Mahdia 
Published: March 2022

AbstractBackgroundExploring lived experiences of recovered COVID-19 patients might have scientific, social, and policy relevance that can apply to the healthcare infrastructure. This multi-center descriptive phenomenological study was conducted to explore lived experiences of Palestinian patients who recovered from COVID-19. MethodsThis was a descriptive phenomenological study. A purposive sampling technique was used to recruit the study participants. Semi-structured qualitative interviews were conducted with patients who recovered from COVID-19 (n = 20). The interviews were transcribed verbatim. The transcripts were analyzed using Colaizzi’s phenomenological approach which consisted of the following steps: 1) familiarization, 2) identification of significant statements, 3) formulation of the meanings, 4) clustering the themes, 5) development of an exhaustive description of the phenomenon, 6) production of the fundamental structure, and 7) verification of the fundamental structure.ResultsSemi-structured interviews were conducted with 14 male and 6 female patients who recovered from COVID-19. The total duration of the interview time was 998 min (16.6 h). The qualitative data collected during the interviews were categorized into 5 major themes and 16 subthemes that exhaustively described the phenomenon. The major themes were relevant to: 1) emotions after learning about the infection, 2) experiencing social exclusion and stigma, 3) the experienced symptoms, 4) supportive treatments, herbs, rituals, and social support, 5) and life after recovery.ConclusionThe interviewees recounted experiencing negative emotions, social exclusion, and stigma because of their infection. It may be important for mental health promotion to be an integral part of the care plan for patients with COVID-19. More studies are still needed to investigate if introducing mental healthcare providers to the care team of patients with COVID-19 can improve the experiences of the patients.
Fat infiltration of paraspinal muscles as an independent risk for bone nonunion after posterior lumbar interbody fusion
Authors: Han Gengyu , Zou Da , Liu Zexiang , Zhang Bo , Gong Chunjie , Zhou Siyu , Li Wei , Sun Zhuoran , Li Weishi 
Published: March 2022

Abstract
Background
The prognosis value of paraspinal muscle degeneration on clinical outcomes has been revealed. However no study has investigated the effect of the fat infiltration (FI) of paraspinal muscles on bone nonunion after posterior lumbar interbody fusion (PLIF).

Methods
Three hundred fifty-one patients undergoing PLIF for lumbar spinal stenosis with 1-year follow-up were retrospectively identified. Patients were categorized into bone union (n = 301) and bone nonunion (n = 50) groups based on dynamic X-ray at 1-year follow-up. The relative total cross-sectional area (rTCSA) and FI of multifidus (MF) and erector spinae (ES), and the relative functional CSA (rFCSA) of psoas major (PS) were measured on preoperative magnetic resonance imaging.

Results
The nonunion group had a significantly higher MF FI and a higher ES FI and a smaller MF rTCSA than the union group (p = 0.001, 0.038, 0.026, respectively). Binary logistic regression revealed that MF FI (p = 0.029, odds ratio [OR] = 1.04), lumbosacral fusion (p = 0.026, OR = 2193) and length of fusion (p = 0.001, OR = 1.99) were independent factors of bone nonunion. In subgroup analysis, in one or two-level fusion group, the patients with nonunion had a higher MF FI and a higher ES FI than those of the patients with union (all p < 0.05). Similarly, in lumbosacral fusion group, the patients with nonunion had a higher MF FI and a higher ES FI than those of the patients with union (all p < 0.05). The logistic regressions showed that MF FI remained an independent factor of bone nonunion both in the patients with one or two-level fusion (p = 0.003, OR = 1.074) and in the patients with lumbosacral fusion (p = 0.006, OR = 1.073).

Conclusions
Higher fatty degeneration was strongly associated with bone nonunion after PLIF. Surgeons should pay attention to the FI of paraspinal muscles when performing posterior surgery for patients, especially those who need short-segment fusion or to extend fusion to S1.
Incidence of upper extremity deep vein thrombosis in the retrosternal reconstruction after esophagectomy
Authors: Yamada Leo , Saito Motonobu , Suzuki Hiroya , Mochizuki Shotaro , Endo Eisei , Kase Koji , Ito Misato , Nakano Hiroshi , Yamauchi Naoto , Matsumoto Takuro , Kaneta Akinao , Kanke Yasuyuki , Onozawa Hisashi , Hanayama Hiroyuki , Okayama Hirokazu , Fujita Shotaro , Sakamoto Wataru , Watanabe Yohei , Hayase Suguru , Saze Zenichiro , Momma Tomoyuki , Ohki Shinji , Kono Koji 
Published: March 2022

Abstract
Background
Upper extremity deep vein thrombosis (UEDVT) is relatively rare but cannot be negligible because it can cause fatal complications. Although it is reported that the occurrence rate of UEDVT has increased due to central venous catheter (CVC), cancer, and surgical invasion, there is still limited information for esophagectomy. The aim of this study was to evaluate the clinical factors, including CVC placement and thromboprophylaxis approach, as well as retrosternal space’s width as a predictive factor for UEDVT in patients receiving esophagectomy.

Methods
This study included 66 patients who underwent esophagectomy with retrosternal reconstruction using a gastric tube. All patients routinely underwent contrast-enhanced computed tomography (CT) on the 4th postoperative day. Low-molecular-weight-heparin (LMWH) was routinely administered by the 2nd postoperative day. To evaluate retrosternal space’s width, (a) The distance from sternum to brachiocephalic artery and (b) the distance from sternum to vertebra were measured by preoperative CT, and the ratio of (a) to (b) was defined as the width of retrosternal space.

Results
Among all patients, 11 (16.7%) suffered from UEDVT, and none was preoperatively received CVC placement, while 7 were inserted in non-UEDVT cases. Retrosternal space’s width in patients with UEDVT was significantly smaller than that in patients without UEDVT (0.17 vs. 0.26; P < 0.0001). A cutoff value of the width was 0.21, which has high sensitivity (87%) and specificity (82%) for UEDVT prediction, respectively.

Conclusion
The existence of CVC may not affect the development of UEDVT, but preoperative evaluation of retrosternal ratio may predict the occurrence of UEDVT.
Infliximab therapy in refractory sarcoidosis: a multicenter real-world analysis
Authors: Sakkat Abdullah , Cox Gerard , Khalidi Nader , Larche Maggie , Beattie Karen , Renzoni Elisabetta A. , Morar Nilesh , Kouranos Vasilis , Kolb Martin , Hambly Nathan 
Published: March 2022

Abstract
Background
Infliximab is a monoclonal antibody that binds and neutralizes circulating tumor necrosis factor-alpha, a key inflammatory cytokine in the pathophysiology of sarcoidosis. Despite the paucity of randomized clinical trials, infliximab is often considered a therapeutic option for refractory disease. Our study aimed to investigate the effectiveness of infliximab in patients with refractory sarcoidosis.

Methods
Sarcoidosis patients from three tertiary centres were retrospectively identified by pharmacy records based on treatment with infliximab. Treatment with Infliximab was initiated in patients who failed first and second line immunomodulators as determined by a multidisciplinary team of Respirologists, Dermatologists, ENT specialists, Rheumatologists, and Neurologists. Participants were characterized by the primary organ for which infliximab was initiated and the total number of organs involved. Clinical outcomes were categorized as treatment success versus failure. We defined treatment success as (A) improvement of cutaneous, upper airway, lymph node, gastrointestinal, eye, or joint manifestations; or (B) improvement or no change in central nervous system (CNS) or pulmonary manifestations.

Results
33 patients with refractory sarcoidosis were identified. The proportion of treatment success was 100% (95% CI 54.1–100) in CNS, 91.7% (95% CI 61.5–99.8) in cutaneous, 78.6% (95% CI 49.2–95.3) in pulmonary and 71.5% (95% CI 29.0–96.3) in upper airway disease. The use of infliximab was associated with a reduction prednisone dose by 50%.

Conclusion
Infliximab is possibly an effective therapy for refractory sarcoidosis, with the greatest value in neurologic and cutaneous manifestations. Across all disease presentations, infliximab facilitated a clinically relevant reduction in corticosteroid dose. Relapse is common after discontinuation of infliximab.