bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice
Authors: Shyu Yu‐Chiau , Liao Po‐Cheng , Huang Ting‐Shou , Yang Chun‐Ju , Lu Mu‐Jie , Huang Shih‐Ming , Lin Xin‐Yu , Liou Cai‐Cin , Kao Yu‐Hsiang , Lu Chi‐Huan , Peng Hui‐Ling , Chen Jim‐Ray , Cherng Wen‐Jin , Yang Ning‐I , Chen Yung‐Chang , Pan Heng‐Chih , Jiang Si‐Tse , Hsu Chih‐Chin , Lin Gigin , Yuan Shin‐Sheng , Hsu Paul Wei‐Che , Wu Kou‐Juey , Lee Tung‐Liang , Shen Che‐Kun James 
Published: July 2022

AbstractThe quest for rejuvenation and prolonged lifespan through transfusion of young blood has been studied for decades with the hope of unlocking the mystery of the key substance(s) that exists in the circulating blood of juvenile organisms. However, a pivotal mediator has yet been identified. Here, atypical findings are presented that are observed in a knockin mouse model carrying a lysine to arginine substitution at residue 74 of Krüppel‐like factor 1 (KLF1/EKLF), the SUMOylation‐deficient Klf1K74R/K74R mouse, that displayed significant improvement in geriatric disorders and lifespan extension. Klf1K74R/K74R mice exhibit a marked delay in age‐related physical performance decline and disease progression as evidenced by physiological and pathological examinations. Furthermore, the KLF1(K74R) knockin affects a subset of lymphoid lineage cells; the abundance of tumor infiltrating effector CD8+ T cells and NKT cells is increased resulting in antitumor immune enhancement in response to tumor cell administration. Significantly, infusion of hematopoietic stem cells (HSCs) from Klf1K74R/K74R mice extends the lifespan of the wild‐type mice. The Klf1K74R/K74R mice appear to be an ideal animal model system for further understanding of the molecular/cellular basis of aging and development of new strategies for antiaging and prevention/treatment of age‐related diseases thus extending the healthspan as well as lifespan.
Phosphorus‐Doped Graphene Aerogel as Self‐Supported Electrocatalyst for CO2‐to‐Ethanol Conversion
Authors: Yang Fangqi , Liang Caihong , Yu Haoming , Zeng Zheling , Lam Yeng Ming , Deng Shuguang , Wang Jun 
Published: July 2022

AbstractElectrochemical reduction of carbon dioxide (CO2) to ethanol is a promising strategy for global warming mitigation and resource utilization. However, due to the intricacy of C─C coupling and multiple proton–electron transfers, CO2‐to‐ethanol conversion remains a great challenge with low activity and selectivity. Herein, it is reported a P‐doped graphene aerogel as a self‐supporting electrocatalyst for CO2 reduction to ethanol. High ethanol Faradaic efficiency (FE) of 48.7% and long stability of 70 h are achieved at −0.8 VRHE. Meanwhile, an outstanding ethanol yield of 14.62 µmol h−1 cm−2 can be obtained, outperforming most reported electrocatalysts. In situ Raman spectra indicate the important role of adsorbed *CO intermediates in CO2‐to‐ethanol conversion. Furthermore, the possible active sites and optimal pathway for ethanol formation are revealed by density functional theory calculations. The graphene zigzag edges with P doping enhance the adsorption of *CO intermediate and increase the coverage of *CO on the catalyst surface, which facilitates the *CO dimerization and boosts the EtOH formation. In addition, the hierarchical pore structure of P‐doped graphene aerogels exposes abundant active sites and facilitates mass/charge transfer. This work provides inventive insight into designing metal‐free catalysts for liquid products from CO2 electroreduction.
Developing a supervised machine‐learning model capable of distinguishing fiber orientation of polymer composite samples nondestructively tested using active ultrasonics
Authors: Bedrosian Austin D. , Thompson Michael R. , Hrymak Andrew , Lanza Gisela 
Published: July 2022

AbstractThis study evaluated the paired performance of different signal processing techniques and supervised learning models being capable of identifying subtle differences in otherwise similar acoustic signals related to detecting the fiber orientation of a polymer composite. Projection of Latent Structures models demonstrated poor predictive capabilities of the composite structure based on spectral analysis of the acoustic signal. AI based models showed great improvements to the capabilities, with artificial neural network modeling exceeding Convolutional Neural Networks for correct classification accuracies. The continuous wavelet transfer highlighted the greatest degree of differences in the signal response compared with fast Fourier Transformation or short time Fourier transformation. The use of regression‐based predictions over classification‐based was found to greatly improve the predictive capabilities of the models, especially when multiple fiber orientations were present in a sample. A time‐based analysis of spectral data showed the frequencies of the signal changed based on the orientation of the fibers. The acoustic signals for the samples with multiple fiber orientations contained individual artifacts representing components of each individual orientation. Use of the frequency domain was shown as capable of observing the targeted fiber information within the bulk material in real‐time. This work shows great promise for composite material predictions using active ultrasonics, with the potential to be implemented into in‐line systems.
A Mechanochemical, Catalyst‐Free Cascade Synthesis of 1,3‐Diols and 1,4‐Iodoalcohols Using Styrenes and Hypervalent Iodine Reagents
Authors: Pan Liangkun , Zheng Long , Chen Ye , Ke Zhihai , Yeung Ying‐Yeung 
Published: July 2022

AbstractA mechanochemical and solvent/catalyst‐free functionalization of olefins with hypervalent iodine reagents has been developed, enabling the synthesis of 1,3‐dioxygenated compounds. Under similar reaction conditions with the addition of molecular iodine, 1,4‐iodoalcohols can be synthesized. These valuable products are non‐trivial to achieve via standard solution‐phase methods. Mechanistic study reveals that the hypervalent iodine reagent might dimerize at solid state with the help of mechanical force. The active monomeric form of hypervalent iodine reagent might trigger the 1,3‐ and 1,4‐difunctionalization reactions in an intermolecular cascade manner.
Dual Reactivity of a Geometrically Constrained Phosphenium Cation
Authors: Volodarsky Solomon , Bawari Deependra , Dobrovetsky Roman 
Published: July 2022

AbstractA geometrically constrained phosphenium cation in bis(pyrrolyl)pyridine based NNN pincer type ligand (1+) was synthesized, isolated and its preliminary reactivity was studied with small molecules.1+reacts with MeOH and Et2NH, activating the O−H and N−H bonds via a P‐center/ligand assisted path. The reaction of1+with one equiv. of H3NBH3leads to its dehydrogenation producing5. Interestingly, reaction of1+with an excess H3NBH3leads to phosphinidene (PI) species coordinating to two BH3molecules (6). In contrast, [1+][OTf] reacts with Et3SiH by hydride abstraction yielding1‐Hand Et3SiOTf, while [1+][B(C6F5)4] reacts with Et3SiH via an oxidative addition type reaction of Si−H bond to P‐center, affording a new PVcompound (8). However,8is not stable over time and degrades to a complex mixture of compounds in matter of minutes. Despite this, the ability of [1+][B(C6F5)4] to activate Si−H bond could still be tested in catalytic hydrosilylation of benzaldehyde, where1+closely mimics transition metal behaviour.
Highly Regioselective Cobalt‐Catalyzed Hydroboration of Internal Alkynes
Authors: Zhang Yan‐Dong , Li Xiao‐Yu , Mo Qian‐Kun , Shi Wen‐Bin , Zhao Jia‐Bao , Zhu Shou‐Fei 
Published: July 2022

AbstractHerein, we report the development of new Co complexes that have cyclopropane‐based diphosphine ligands and can catalyze highly chemo‐, regio‐, and stereoselective hydroboration reactions of unsymmetrical internal alkynes. These reactions exhibited unusual regioselectivity: specifically, reactions of aryl alkyl internal alkynes showed excellent cis‐β‐addition selectivity, and reactions of dialkyl internal alkynes gave excellent cis‐α‐addition selectivity. Highly regioselective hydroboration of unsymmetrical dialkyl internal alkynes cannot be achieved by other known methods. The reactions described herein are highly synthetically useful, particularly for the stereoselective synthesis of trisubstituted alkenylborates and alkenes. Mechanistic studies indicate that a CoI−H species is a plausible active catalyst and the rigid structure of the cyclopropane skeleton of the ligands and the crowded reaction pocket were responsible for the unprecedented regioselectivity.
Mass Spectrometry Detection and Imaging of a Non‐Covalent Protein–Drug Complex in Tissue from Orally Dosed Rats
Authors: Illes‐Toth Eva , Hale Oliver J. , Hughes James W. , Strittmatter Nicole , Rose Jonathan , Clayton Ben , Sargeant Rebecca , Jones Stewart , Dannhorn Andreas , Goodwin Richard J. A. , Cooper Helen J. 
Published: July 2022

AbstractHere, we demonstrate detection by mass spectrometry of an intact protein–drug complex directly from liver tissue from rats that had been orally dosed with the drug. The protein–drug complex comprised fatty acid binding protein 1, FABP1, non‐covalently bound to the small molecule therapeutic bezafibrate. Moreover, we demonstrate spatial mapping of the [FABP1+bezafibrate] complex across a thin section of liver by targeted mass spectrometry imaging. This work is the first demonstration of in situ mass spectrometry analysis of a non‐covalent protein–drug complex formed in vivo and has implications for early stage drug discovery by providing a route to target‐drug characterization directly from the physiological environment.
High‐Performance Thermoelectric α‐Ag9Ga1−xTe6 Compounds with Ultralow Lattice Thermal Conductivity Originating from Ag9Te2 Motifs
Authors: Tang Yingfei , Yu Yimeng , Zhao Na , Liu Keke , Chen Haijie , Stoumpos Constantinos C. , Shi Yixuan , Chen Shuo , Yu Lingxiao , Wu Jinsong , Zhang Qingjie , Su Xianli , Tang Xinfeng 
Published: July 2022

AbstractWe have determined the complex atomic structure of high‐temperature α‐Ag9GaTe6 phase with a hexagonal lattice (P63mc space group, a=b=8.2766 Å, c=13.4349 Å). The structure has outer [GaTe4]5− tetrahedrons and inner [Ag9Te2]5+ clusters. All of the Ag ions are disorderly distributed in the lattice. Seven types of the Ag atoms constitute the cage‐like [Ag9Te2]5+ clusters. The highly disordered Ag ions vibrate in‐harmonically, producing strong coupling between low frequency optical phonons and acoustic phonons. This in conjunction with a low sound velocity of 1354 m s−1 leads to an ultralow thermal conductivity of 0.20 W m−1 K−1 at 673 K. Meanwhile, the deficiency of Ga in Ag9Ga1−xTe6 compounds effectively optimizes the electronic transport properties. Ag9Ga0.91Te6 attains a highest power factor of 0.40 mW m−1 K−2 at 673 K. All these contribute to a much‐improved ZT value of 1.13 at 623 K for Ag9Ga0.95Te6, which is 41 % higher than that of the pristine Ag9GaTe6 sample.
Reactions of Frustrated Lewis Pairs with Chloro‐Diazirines: Cleavage of N=N Double Bonds
Authors: Mandal Dipendu , Chen Ting , Qu Zheng‐Wang , Grimme Stefan , Stephan Douglas W. 
Published: July 2022

AbstractThe reactions of FLPs with diazomethanes leads to the rapid loss of N2. In contrast, in this work, we reported reactions of phosphine/borane FLPs with chlorodiazirines which led to the reduction of the N=N double bond, affording linked phosphinimide/amidoborate zwitterions of the general form R3PNC(Ar)NR′BX(C6F5)2. A detailed DFT mechanistic study showed that these reactions proceed via FLP addition to the N=N bond, followed by subsequent group transfer reactions to nitrogen and capture of the halide anion.
Azulene‐Fused Acenes
Authors: Ong Albert , Tao Tao , Jiang Qing , Han Yi , Ou Yaping , Huang Kuo‐Wei , Chi Chunyan 
Published: July 2022

AbstractNon‐alternant non‐benzenoid π‐conjugated polycyclic hydrocarbons (PHs) are expected to exhibit very different electronic properties from the all‐benzenoid PHs. Herein, we report the synthesis and physical properties of three azulene‐fused acene molecules (1, 2 and 3), which are isoelectronic to the pentacene, hexacene and heptacene, respectively. X‐ray crystallographic analysis, NMR spectra, and theoretical calculations reveal a localised aromatic backbone comprising all the six‐ and five‐membered rings while the seven‐membered ring remains non‐aromatic. They display properties of both azulene and acenes and are much more stable than the respective acenes. The dications of 1, 2 and 3 were formed by chemical oxidation. Notably, 32+ exhibited an open‐shell diradical character (y0=30.2 %) as confirmed by variable‐temperature NMR and ESR measurements, which can be explained by recovery of aromaticity of an 2,6‐anthraquinodimethane unit annulated with two aromatic tropylium rings.
Soft pneumatic actuator from particle reinforced silicone rubber: Simulation and experiments
Authors: Lv Zhongming , Hao Wentao , Xiao Feiyun , Chen Pin , Liu Zhengshi , Wang Yong 
Published: July 2022

AbstractSoft actuators are important parts of soft robotics. Particle reinforcement can effectively improve their durability, reliability and life span. However, there is a lack of such actuators. Herein, we report experiments and simulation on soft pneumatic actuators from silicone rubber embedding ultrahigh molecular weight polyethylene (UHMWPE) particles. The experimental results indicate that the UHMWPE particles are uniformly distributed in silicone rubber matrix, leading to improved puncture resistance and hardness. Meanwhile, the obtained soft actuators show controllable bending angle and contact force via tuning the input air pressure. The simulation results by finite element method agree well with that from experiments in most cases, proving its applicability in the design and prediction of soft actuators composed from particle embedding rubbers. This work gives a good example to the research on soft actuators from particle embedding rubber composites, including the multifunctional actuators with conductive or magnetic particles.
Stretchable, conductive poly(acrylamide‐co‐maleic acid)/triethylene glycol/NaCl double‐crosslinked organohydrogel with excellent antifreezing and sensing properties
Authors: Liu Guanfei , Guo Meiling , Xue Shishan , Yang Xi , Wang Li , Zhao Chuanxia , Xiang Dong , Li Hui , Lai Jingjuan , Li Zhenyu , Wu Yuanpeng 
Published: July 2022

AbstractRecently, the wearable electronic devices have attracted extensive attention while the low stretchability and freezing‐induced performance deterioration largely limit the applications in many fields. In this work, the poly(acrylamide‐co‐maleic acid) hydrogels are immersed in the triethylene glycol/sodium chloride/water solution to establish the dual‐crosslinked organohydrogels, which present the extraordinary stretchability (1322 ± 75%) ascribed to the energy dissipation of physical interactions and stability of chemical crosslinked networks. Triethylene glycol forms strong hydrogen bonds with water, which interfere with the formation of intermolecular hydrogen bonds among water molecules at low temperatures and inhibit the formation of ice crystals in the organohydrogel networks. Sodium chloride imparts excellent electrical conductivity to the organohydrogel. As a result, a stretchable electronic sensor based on the organohydrogel is fabricated, which is strain‐sensitive with a wide strain sensing window (0%–440%) and excellent stability. More importantly, the sensor based on the as‐prepared organohydrogel could precisely detect various activities of the human model at −30°C leading to the widely application prospects.
Superhydrophobic tough hierarchical porous thermal insulation composites prepared by in situ formation of silica aerogel in collagen fiber matrix
Authors: Yang Kaifeng , Zhang Zetian , Liu Yang , Li Shan , Chen Deyan , Li Zhengjun 
Published: July 2022

AbstractThe serious problem of energy consumption and the requirement for sustainable development has attracted people's extensive attention. The application of high‐efficiency thermal insulation materials can reduce consumption and waste in the process of energy transfer, and is the most effective way to save energy and protect the environment. Among many thermal insulation materials, silica aerogel, especially biomass fiber‐reinforced silica aerogel with good mechanical strength, shows great practical application potential. In this article, the collagen fiber‐silica aerogel composite (MCFF@SiO2) was successfully prepared by in situ sol–gel method and freeze‐drying method, innovatively using skin collagen fiber matrix with natural porous skeleton as reinforcing template. MCFF@SiO2 has good thermal stability, and has a hierarchical porous structure formed by filling nanoscale mesopores of silica aerogel in the macropores of collagen fiber matrix, thus delaying the spread of heat. Particularly, MCFF@SiO2 exhibits good thermal insulation performance, and its thermal conductivity is 0.068 W/(m K), which is lower than that of MCFF. In addition, MCFF@SiO2 shows superhydrophobicity, good mechanical properties, excellent flame retardancy, and self‐extinguishing performance. The prepared composite aerogels have potential application value in the field of thermal management, and this work is expected to provide inspiration for the preparation of biomass‐based porous functional materials.
Safety and Efficacy of Bimekizumab in Patients With Active Ankylosing Spondylitis: Three‐Year Results From a Phase IIb Randomized Controlled Trial and Its Open‐Label Extension Study
Authors: Baraliakos Xenofon , Deodhar Atul , Dougados Maxime , Gensler Lianne S. , Molto Anna , Ramiro Sofia , Kivitz Alan J. , Poddubnyy Denis , Oortgiesen Marga , Vaux Thomas , Fleurinck Carmen , Shepherd‐Smith Julie , de la Loge Christine , de Peyrecave Natasha , van der Heijde Désirée 
Published: July 2022

ObjectiveTo assess the long‐term safety, tolerability, and efficacy of bimekizumab in patients with active ankylosing spondylitis (AS).MethodsPatients with active AS who completed the dose‐ranging, 48‐week BE AGILE randomized controlled trial were eligible to participate in an open‐label extension (OLE) study, in which patients received 160 mg of bimekizumab every 4 weeks. We present the safety and efficacy results through 156 weeks. Missing efficacy data were imputed using nonresponder imputation analysis for binary outcomes and multiple imputation for continuous outcomes.ResultsFrom weeks 0–156, 280 of 303 patients (exposure‐adjusted incidence rate 141.0 per 100 patient‐years) experienced ≥1 treatment‐emergent adverse event; the most frequent adverse events were nasopharyngitis (8.1 per 100 patient‐years) and upper respiratory tract infection (5.0 per 100 patient‐years). Additionally, 67 of 303 patients (9.8 per 100 patient‐years) had mild to moderate localized fungal infections (28 of 303 patients had Candida infections [3.7 per 100 patient‐years] and 23 of 303 patients had oral candidiasis [3.0 per 100 patient‐years]), 10 patients had serious infections (1.3 per 100 patient‐years), and no cases of active tuberculosis were reported. Active inflammatory bowel disease (1.1 per 100 patient‐years), anterior uveitis (0.7 per 100 patient‐years), and adjudicated major adverse cardiovascular events (0.3 per 100 patient‐years) were infrequent. The efficacy of bimekizumab treatment demonstrated at week 48 was sustained in the OLE study. At week 156, nonresponder imputation analysis showed that 53.7% of patients (72.6% of observed cases) met the Assessment of SpondyloArthritis international Society criteria for 40% improvement and 28.0% of patients (37.9% of observed cases) achieved partial remission; Ankylosing Spondylitis Disease Activity Scores were reduced from baseline (mean ± SEM 3.9 ± 0.1) to week 48 (2.1 ± 0.1) and week 156 (1.9 ± 0.1) (multiple imputation). Patients showed sustained improvements in pain, fatigue, physical function, and health‐related quality of life.ConclusionThe safety profile of bimekizumab was found to be consistent with previously demonstrated findings, and no new safety signals were identified. The efficacy of bimekizumab in patients with AS was sustained through 3 years of treatment.
Telomere Length and Development of Systemic Lupus Erythematosus: A Mendelian Randomization Study
Authors: Wang Xu‐Fan , Xu Wen‐Jing , Wang Fei‐Fei , Leng Rui , Yang Xiao‐Ke , Ling Hua‐Zhi , Fan Yin‐Guang , Tao Jin‐Hui , Shuai Zong‐Wen , Zhang Li , Ye Dong‐Qing , Leng Rui‐Xue 
Published: July 2022

ObjectivePrevious observational studies demonstrated that a subset of patients with systemic lupus erythematosus (SLE) have markedly short telomere length in leukocytes. This study was undertaken to test whether leukocyte telomere length is causally associated with risk of SLE.MethodsA 2‐sample Mendelian randomization (MR) analysis was conducted to estimate causality of telomere length on SLE in European populations. A replication 2‐sample MR study using Asian genetic data was also conducted. A reverse MR analysis was then performed to test the effects of SLE on telomere length. The autoantibodies targeting telomere‐associated protein (telomeric repeat–binding factor 1 [TERF1] autoantibodies) were detected in patients with SLE, healthy controls, and patients with rheumatoid arthritis.ResultsThe results of the inverse variance–weighted method (odds ratio [OR] 2.96 [95% confidence interval (95% CI) 1.58–5.55], P < 0.001) showed strong evidence for a causal relationship between longer telomere length and risk of SLE in people with European ancestry. The outcomes of MR‐Egger regression analysis (OR 29.46 [95% CI 3.02–287.60], P = 0.033) and MR pleiotropy residual sum and outlier analysis (OR 3.62 [95% CI 2.03–6.46], P = 0.002) also showed that longer telomere length was significantly associated with increased risk of SLE in a European population. Sensitivity analyses using different methods and summary data sets showed that the results were still broadly consistent. A replication MR study using Asian genetic data yielded similar findings. However, the reverse MR analysis showed that genetically predicted SLE was not causally associated with telomere length. In addition, we found that TERF1 autoantibodies were present in 2 of 40 SLE patients (5.0%).ConclusionIn contrast with previous observational studies, MR analyses show that longer telomere length is significantly associated with increased risk of SLE.
Photoluminescent and photochromic smart window from recycled polyester reinforced with cellulose nanocrystals
Authors: Al‐Balakocy Naser G. , Abdelrahman Meram S. , Ahmed Hend , Badawy Abdelrahman A. , Ghanem Ahmed F. , Wassel Ahmed R. , Wen Zhen , Khattab Tawfik A. 
Published: July 2022

AbstractSmart windows with long‐persistent phosphorescence, ultraviolet (UV) light protection, high transparency, and high rigidity were developed by easily immobilizing varying ratios of lanthanide‐activated aluminate phosphor nanoscale particles within a composite of recycled polyester/cellulose nanocrystals (RPET/CNC). Cellulose nanocrystals were prepared from rice straw waste. Cellulose nanocrystals were used at low concentration as both crosslinker and drier to improve both transparency and hardness. The phosphor nanoscale particles must be distributed into the recycled polyester/cellulose nanocrystals composite bulk without agglomeration to produce transparent RPET/CNC substrates. Photoluminescence characteristics were also studied using spectroscopic profiles of excitation/emission and decay/lifetime. The hardness efficiency was also examined. This transparent recycled polyester waste/cellulose nanocrystals nanocomposite smart window has been shown to change colour under UV light to strong green and to greenish‐yellow when it is dark, as proved by Commission Internationale de l'éclairage (CIE) laboratory colour parameters. It was found that the afterglow RPET/CNC smart window had phosphorescence intensities of 428, 493, and 523 nm upon excitation at 368 nm. There was evidence of improved UV shielding, photostability, and hydrophobic activity. In the presence of a low phosphor ratio, the luminescent RPET/CNC substrates showed quick and reversible fluorescence photochromic activity when exposed to UV radiation.