bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of agricultural sustainability in European Union countries: a group-based multivariate trajectory approach
Authors: Magrini Alessandro 
Published: March 2022

AbstractSustainability of agriculture is difficult to measure and assess because it is a multidimensional concept that involves economic, social and environmental aspects and is subjected to temporal evolution and geographical differences. Existing studies assessing agricultural sustainability in the European Union (EU) are affected by several shortcomings that limit their relevance for policy makers. Specifically, most of them focus on farm level or cover a small set of countries, and the few exceptions covering a broad set of countries consider only a subset of the sustainable dimensions or rely on cross-sectional data. In this paper, we consider yearly data on 12 indicators (5 for the economic, 3 for the social and 4 for the environmental dimension) measured on 26 EU countries in the period 2004–2018 (15 years), and apply group-based multivariate trajectory modeling to identify groups of countries with common trends of sustainable objectives. An expectation-maximization algorithm is proposed to perform maximum likelihood estimation from incomplete data without relying on an explicit imputation procedure. Our results highlight three groups of countries with distinguished strong and weak sustainable objectives. Strong objectives common to all the three groups include improvement of productivity, increase of personal income in rural areas, reduction of poverty in rural areas, increase of production of renewable energy, rise of organic farming and reduction of nitrogen balance. Instead, enhancement of manager turnover and reduction of greenhouse gas emissions are weak objectives common to all the three groups of countries. Our findings represent a valuable resource to formulate new schemes for the attribution of subsidies within the Common Agricultural Policy (CAP).
Conservation of Latin America freshwater biodiversity: beyond political borders
Authors: Kuemmerlen Mathias , Batista-Morales Angélica María , Bruder Andreas , Turak Eren , de Oliveira Roque Fabio 
Published: March 2022

AbstractLatin America’s tremendous socio-cultural and biological diversity has evolved along tightly intertwined, far-reaching river networks. Decisions taken by any one country, may have strong impacts on the regional and even global biodiversity conservation agenda, such as the Convention on Biological Diversity. Here we comment on four perspectives complementing actions suggested by Azevedo-Santos et al. (2021) in their Commentary “Conservation of Brazilian freshwater biodiversity: Thinking about the next 10 years and beyond”. This contribution aims at attaining an effective conservation of freshwater biodiversity in Latin America, particularly in the context of the ongoing negotiations on the Global Biodiversity Framework. Our suggestions put forward cross-border perspectives, urging governments to engage in actions that consider the reality of and threats to transnational ecosystems such as many river basins of Latin America and elsewhere.
Making Sense of Vicarious Responsibility: Moral Philosophy Meets Legal Theory
Authors: Glavaničová Daniela , Pascucci Matteo 
Published: March 2022

AbstractVicarious responsibility is a notoriously puzzling notion in normative reasoning. In this article we will explore two fundamental issues, which we will call the “explication problem” and the “justification problem”. The former issue concerns how vicarious responsibility can plausibly be defined in terms of other normative concepts. The latter issue concerns how ascriptions of vicarious responsibility can be justified. We will address these two problems by combining ideas taken from legal theory and moral philosophy. Our analysis will emphasise the importance of the voluntary involvement of the normative parties considered liable in a relation with other normative parties who causally contributed to a prohibited state-of-affairs.
A Change of Heart: Human Cardiac Tissue Engineering as a Platform for Drug Development
Authors: Bremner Samantha B. , Gaffney Karen S. , Sniadecki Nathan J. , Mack David L. 
Published: March 2022

Abstract
Purpose of Review
Human cardiac tissue engineering holds great promise for early detection of drug-related cardiac toxicity and arrhythmogenicity during drug discovery and development. We describe shortcomings of the current drug development pathway, recent advances in the development of cardiac tissue constructs as drug testing platforms, and the challenges remaining in their widespread adoption.

Recent Findings
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have been used to develop a variety of constructs including cardiac spheroids, microtissues, strips, rings, and chambers. Several ambitious studies have used these constructs to test a significant number of drugs, and while most have shown proper negative inotropic and arrhythmogenic responses, few have been able to demonstrate positive inotropy, indicative of relative hPSC-CM immaturity.

Summary
Several engineered human cardiac tissue platforms have demonstrated native cardiac physiology and proper drug responses. Future studies addressing hPSC-CM immaturity and inclusion of patient-specific cell lines will further advance the utility of such models for in vitro drug development.
Impact of metal mining on per capita family income in Peru
Authors: Mamani René Paz Paredes , Mayta Roberto Arpi , Flores Roberto Chávez , Uchiri Faustino Ccama 
Published: March 2022

Abstract
The objective of the research was to measure the impact of metal mining production on per capita family income at the district level, during the period 2003 and 2019. For this purpose, the data from the United Nations report and the econometric methodology of difference in differences were used with and without spatial effects. The results without spatial effect show that the impact of mining on monthly per capita family income between 2003 and 2019 was 207.42 soles. However, considering the effects of spatial spillover, the total impact was 291.61 soles, which is decomposed into a direct and indirect impact of 189.77 soles and 101.84 soles, respectively. Likewise, the results suggest that there is a total impact of 77.25 soles on the per capita family income of the neighboring non-mining district. These results suggest that there is ample space for the design and implementation of public policies for the mining sector.
21-Component compositionally complex ceramics: Discovery of ultrahigh-entropy weberite and fergusonite phases and a pyrochlore-weberite transition
Authors: Qin Mingde , Vega Heidy , Zhang Dawei , Adapa Sarath , Wright Andrew J. , Chen Renkun , Luo Jian 
Published: March 2022

AbstractTwo new high-entropy ceramics (HECs) in the weberite and fergusonite structures, along with the unexpected formation of ordered pyrochlore phases with ultrahigh-entropy compositions and an abrupt pyrochlore-weberite transition, are discovered in a 21-component oxide system. While the Gibbs phase rule allows 21 equilibrium phases, 9 out of the 13 compositions examined possess single HEC phases (with ultrahigh ideal configurational entropies: ∼2.7kB per cation or higher on one sublattice in most cases). Notably, (15RE1/15)(Nb1/2Ta1/2)O4 possess a single monoclinic fergusonite (C2/c) phase, and (15RE1/15)3(Nb1/2Ta1/2)1O7 form a single orthorhombic (C2221) weberite phase, where 15RE1/15 represents Sc1/15Y1/15La1/15Pr1/15Nd1/15Sm1/15Eu1/15Gd1/15Tb1/15Dy1/15Ho1/15Er1/15Tm1/15 Yb1/15Lu1/15. Moreover, a series of eight (15RE1/15)2+x(Ti1/4Zr1/4Ce1/4H1/4)2−2x(Nb1/2Ta1/2)xO7 specimens all exhibit single phases, where a pyrochlore-weberite transition occurs within 0.75 < x < 0.8125. This cubic-to-orthorhombic transition does not change the temperature-dependent thermal conductivity appreciably, as the amorphous limit may have already been achieved in the ultrahigh-entropy 21-component oxides. These discoveries expand the diversity and complexity of HECs, towards many-component compositionally complex ceramics (CCCs) and ultrahigh-entropy ceramics.
State of the art review on physiochemical and engineering characteristics of fly ash and its applications
Authors: Ram Amit Kumar , Mohanty Supriya 
Published: March 2022

AbstractThe focus of this study is to critically review the physiochemical and engineering properties of the fly ash and its applications in various fields. The utilization of fly ash has become a widespread area, but the amount of utilization is still a serious issue. It has many beneficial qualities (such as pozzolanic property, fineness, spherical shape, lightweight, etc.), which enhance its properties and make it suitable for its utilization as a new construction material. For the bulk utilization of fly ash, it should be employed in the areas independent of any other parameters. So that, the disposal problem can be reduced significantly. The knowledge of its physiochemical characteristic helps in the judgment of appropriate fly ash for any particular type of work. Fly ash can be utilized in other areas such as asphalt concrete, geopolymer concrete, ground improvement, agricultural sector, roller compacted concrete, brick, etc. that will reduce the existing ashes, and also the disposal problem can be solved appreciably. The implementation of fly ash must be avoided below the natural ground water level and below 4 °C temperature conditions.
Perfusion-Based Recellularization of Rat Livers with Islets of Langerhans
Authors: Demko Peter , Hillebrandt Karl H. , Napierala Hendrik , Haep Nils , Tang Peter , Gassner Joseph M. G. V. , Kluge Martin , Everwien Hannah , Polenz Dietrich , Reutzel-Selke Anja , Raschzok Nathanael , Pratschke Johann , Sauer Igor M. , Struecker Benjamin , Dobrindt Eva M. 
Published: March 2022

Abstract
Purpose
Artificial organs might serve as alternative solutions for whole organ transplantation. Decellularization of a liver provides a non-immunogenic matrix with the advantage of three afferent systems, the portal vein, the hepatic artery and the bile duct. This study aims to evaluate the recellularization of rat livers with islets of Langerhans via the bile duct and the portal vein for the comparison of different perfusion routes.

Methods
Rat livers were decellularized in a pressure-controlled perfusion manner and repopulated with intact isolated islets of Langerhans via either the portal vein or the bile duct.

Results
Repopulation via the portal vein showed islet clusters stuck within the vascular system demonstrated by ellipsoid borders of thick reticular tissue around the islet cluster in Azan staining. After recellularization via the bile duct, islets were distributed close to the vessels within the parenchymal space and without a surrounding reticular layer. Large clusters of islets had a diameter of up to 1000 µm without clear shapes.

Conclusion
We demonstrated the bile duct to be superior to the portal vein for repopulation of a decellularized rat liver with islets of Langerhans. This technique may serve as a bioengineering platform to generate an implantable and functional endocrine neo-pancreas and provide scaffolds with the anatomic benefit of three afferent systems to facilitate co-population of cells.
Understanding the Impact of Spot Market Electricity Price on Wastewater Asset Management Strategy
Authors: Do Phuong , Chow Christopher W. K. , Rameezdeen Raufdeen , Gorjian Nima 
Published: March 2022

Abstract
Development of an advanced pumping control scheme is one of the useful methods that can be applied in operational optimisation of wastewater pumps. Optimisation of pumping control can benefit the utility by overall cost saving using different electricity pricing schemes from the energy market. As electricity prices can be varied based on the spot market in some countries such as Australia, the consideration of operating the pumps at the most favourable electricity price, when managed correctly, can offer remarkable savings. This paper provides understanding on the electricity spot price behaviour of South Australia in the National Electricity Market (NEM). Half-hourly electricity spot price data of over 22 years from January 1999 to June 2021 were analysed to investigate the key characteristics of spot prices, including seasonality (intraday, intraweek and seasonal price patterns), spiky behaviour and occurrences of negative prices. In addition, the possible impacts of other factors on electricity spot prices such as electricity demand and weather conditions on pump control were examined. Results indicate a strong relationship between electricity demand and spot price with the Pearson correlation coefficient up to R = 0.95, and extreme high spot prices tended to occur on scorching days with the maximum temperature above 35 °C when air-conditioner usage was high. This paper also explains the importance of electricity spot prices in the wastewater pump on/off operations and analyses opportunities for cost savings by including electricity spot price forecasts as an input of the smart controller to enhance the efficiency of the real-time pumping control.
Impact of engine oil volatility and viscosity on blow-by aerosol formation
Authors: Scheiber Kai-Michael , Nowak Niclas , Lorenz Magnus Lukas , Pfeil Jürgen , Koch Thomas , Kasper Gerhard 
Published: March 2022

AbstractParticulate emissions from diesel engines are a matter of public concern and continued industrial development. For an internal combustion engine, particles may originate either from the after treatment box or from the crankcase ventilation system. This paper quantifies and discusses particle sources within the crankcase ventilation system of a medium-duty 4-cylinder and a heavy-duty 6-cylinder engine and their dependence on the engine oil parameters viscosity (expressed as Noack number) and HTHS volatility. Crankcase aerosol spectra were measured by an optical particle counter in the size range of 0.3–5 µm. For a few cases data of filter samples downstream the separator unit are discussed for the total blow-by aerosol. Engines were found to behave very similarly with regard to changes in either oil parameter, with volatility generally being the far stronger factor of influence. Total particle mass concentration increased by a factor of up to 5 for a rise in Noack volatility of about 13–25%. The mass concentration downstream of the separator also increases with oil volatility. A variation of HTHS viscosity from 3.5 to 2.6 mPas generated a marginal change in aerosol output by a factor of about 1.2. However, and unexpectedly, the most viscose oil generated the relatively highest particle mass concentrations for both engines.
Preparation and Properties of Antibacterial Polyhexamethylene Biguanide/Palygorskite Composites as Zearalenone Adsorbents
Authors: Kang Yu R. , Mu B. , Zhu G. , Zhu Yong F. , Wang Ai Q. 
Published: March 2022

AbstractDue to the environmental problems derived from the use of common surfactants as modifiers for clay mineral adsorbents to mitigate mycotoxin contamination of animal feeds, finding non-toxic modifiers to prepare safe and efficient adsorbents is necessary. The objective of the present study was, therefore, to modify acidified palygorskite with polyhexamethylene biguanide (PHMB) to obtain antibacterial polyhexamethylene biguanide/palygorskite (PHMB/Plg) composites for the removal of zearalenone, a common mycotoxin. The PHMB/Plg composites were characterized and analyzed by X-ray diffraction, Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy, and isothermal nitrogen adsorption analysis. The adsorption properties of the composites with respect to zearalenone and their antibacterial activity with respect toEscherichia coliandStaphylococcus aureuswere studied. The results indicated that the hydrophobicity of palygorskite was enhanced after modification with PHMB, which could effectively improve the adsorption property of palygorskite toward the nonpolar zearalenone molecules. The adsorption capacity of PHMB/Plg increased with increasing amounts of polyhexamethylene biguanide and increasing pH. The adsorption data were described well by pseudo-second order kinetics and by the Langmuir adsorption model. The maximum adsorption capacity was 2777 μg/g. When the amount of PHMB added increased to 15 wt.%, the composites obtained exhibited good antibacterial performance, and the minimum inhibitory concentrations forEscherichia coliandStaphylococcus aureuswere both at 2.5 mg/mL.
Generalized Bloch type periodicity and applications to semi-linear differential equations in banach spaces
Authors: Wei Yanyan , Chang Yong-Kui 
Published: March 2022

AbstractIn this paper, we mainly introduce some new notions of generalized Bloch type periodic functions namely pseudo Bloch type periodic functions and weighted pseudo Bloch type periodic functions. A Bloch type periodic function may not be Bloch type periodic under certain small perturbations while it can be quasi Bloch type periodic in sense of generalized Bloch type periodic functions. We firstly show the completeness of spaces of generalized Bloch type periodic functions and establish some further properties such as composition and convolution theorems of such functions. We then apply these results to investigate existence results for generalized Bloch type periodic mild solutions to some semi-linear differential equations in Banach spaces. The obtained results show that for each generalized Bloch type periodic input forcing disturbance, the output mild solutions to reference evolution equations remain generalized Bloch type periodic.
Probability, valuations, hyperspace: Three monads on top and the support as a morphism
Authors: Fritz Tobias , Perrone Paolo , Rezagholi Sharwin 
Published: March 2022

AbstractWe consider three monads on
$\mathsf{Top}$
, the category of topological spaces, which formalize topological aspects of probability and possibility in categorical terms. The first one is the Hoare hyperspace monad H, which assigns to every space its space of closed subsets equipped with the lower Vietoris topology. The second one is the monad V of continuous valuations, also known as the extended probabilistic powerdomain. We construct both monads in a unified way in terms of double dualization. This reveals a close analogy between them and allows us to prove that the operation of taking the support of a continuous valuation is a morphism of monads
$V \to H$
. In particular, this implies that every H-algebra (topological complete semilattice) is also a V-algebra. We show that V can be restricted to a submonad of
$\tau$
-smooth probability measures on
$\mathsf{Top}$
. By composing these morphisms of monads, we obtain that taking the supports of
$\tau$
-smooth probability measures is also a morphism of monads.
Hydrogen Flooding of a Coal Core: Effect on Coal Swelling
Authors: Iglauer Stefan , Akhondzadeh Hamed , Abid Hussein , Paluszny Adriana , Keshavarz Alireza , Ali Muhammad , Giwelli Ausama , Esteban Lionel , Sarout Joel , Lebedev Maxim 
Published: March 2022

AbstractHydrogen is a clean fuel which has the potential to drastically decarbonize the energy supply chain. However, hydrogen storage is currently a key challenge; one solution to this problem is hydrogen geo‐storage, with which very large quantities of H2 can be stored economically. Possible target formations are deep coal seams, and coal permeability is a key parameter which determines how fast H2 can be injected and withdrawn again. However, it is well known that gas injection into coal can lead to coal swelling, which drastically reduces permeability. We thus injected H2 gas into a coal core and measured dynamic permeability, while imaging the core via x‐ray micro‐tomography at reservoir conditions. Importantly, no changes in coal cleat morphology or permeability were observed. We conclude that H2 geo‐storage in deep coal seams is feasible from a fundamental petro‐physical perspective; this work thus aids in the large‐scale implementation of a hydrogen economy.
Parameterizing Tabular‐Iceberg Decay in an Ocean Model
Authors: Huth A. , Adcroft A. , Sergienko O. 
Published: March 2022

AbstractLarge tabular icebergs account for the majority of ice mass calved from Antarctic ice shelves, but are omitted from climate models. Specifically, these models do not account for iceberg breakup and as a result, modeled large icebergs could drift to low latitudes. Here, we develop a physically based parameterization of iceberg breakup based on the “footloose mechanism” suitable for climate models. This mechanism describes breakup of ice pieces from the iceberg edges triggered by buoyancy forces associated with a submerged ice foot fringing the iceberg. This foot develops as a result of ocean‐induced melt and erosion of the iceberg freeboard explicitly parameterized in the model. We then use an elastic beam model to determine when the foot is large enough to trigger calving, as well as the size of each child iceberg, which is controlled with the ice stiffness parameter. We test the breakup parameterization with a realistic large iceberg calving‐size distribution in the Geophysical Fluid Dynamics Laboratory OM4 ocean/sea‐ice model and obtain simulated iceberg trajectories and areas that closely match observations. Thus, the footloose mechanism appears to play a major role in iceberg decay that was previously unaccounted for in iceberg models. We also find that varying the size of the broken ice bits can influence the iceberg meltwater distribution more than physically realistic variations to the footloose decay rate.
Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis
Authors: Han Daewon , Kim Haeil , Kim Soojin , Le Qui Anh , Han Seung Yun , Bae Jeongyun , Shin Hye Won , Kang Hyun-Goo , Han Kyung Ho , Shin Jongdae , Park Hwan-Woo 
Published: March 2022

AbstractChronic exposure to bile acid in the liver due to impaired bile flow induces cholestatic liver disease, resulting in hepatotoxicity and liver fibrosis. Sestrin2, a highly conserved, stress-inducible protein, has been implicated in cellular responses to multiple stress conditions and the maintenance of cellular homeostasis. However, its role in cholestatic liver injury is not fully understood. In this study, we investigated the role of hepatic Sestrin2 in cholestatic liver injury and its underlying mechanisms using in vivo and in vitro approaches. Hepatic Sestrin2 expression was upregulated by activating transcription factor 4 (ATF4) and CCAAT/enhancer-binding protein-β (C/EBP-β) after treatment with bile acids and correlated with endoplasmic reticulum (ER) stress responses. Bile-duct ligation (BDL)-induced hepatocellular apoptosis and liver fibrosis were exacerbated in Sestrin2-knockout (Sesn2−/−) mice. Moreover, Sestrin2 deficiency enhanced cholestasis-induced hepatic ER stress, whereas Sestrin2 overexpression ameliorated bile acid-induced ER stress. Notably, the mammalian target of rapamycin (mTOR) inhibitor rapamycin and the AMP-activated protein kinase (AMPK) activator AICAR reversed bile acid-induced ER stress in Sestrin2-deficient cells. Furthermore, Sestrin2 deficiency promoted cholestasis-induced hepatic pyroptosis by activating NLRP3 inflammasomes. Thus, our study provides evidence for the biological significance of Sestrin2 and its relationship with cholestatic liver injury, suggesting the potential role of Sestrin2 in regulating ER stress and inflammasome activation during cholestatic liver injury.