bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality from arterial hypertension in the regions of the Russian Federation in the period from 2013 to 2019
Authors: Samorodskaya I. V. , Semenov V. Yu. 
Published: January 2022

Aim To analyze the dynamics of mortality from arterial hypertension (AH) between 2013 and 2019.Material and methods Arterial hypertension (AH) is one of the most common diseases. At the same time, there are no unified international criteria for establishing the primary cause of death from AH. Data were studied for the period between the end of the program for modernization of health care and the start of the Federal Project “Program for combatting cardiovascular diseases”. Data for 2013-2019 by AH-related codes were provided by the Federal Service of State Statistics on request via the C15 form, “Mortality by gender and one-year age groups”. A standardized mortality ratio, its mean value, standard deviation, and a coefficient of variation were determined for each “cause”. The standardized mortality ratio was calculated using the European standard.Results In Russia during the studied period, the standardized mortality ratio for the death from AH yearly decreased (1.7 times for 6 years; the standardized mortality ratio decreased 1.15 times). However, only in 7 regions, the standardized mortality ratio yearly decreased while in the other regions of the Russian Federation, the standardized mortality ratio changed wavily. In 17 regions of the Russian Federation, the standardized mortality ratio increased in 2019 compared to 2013, including the 31.7 time increase in the Republic of North Ossetia-Alania. In the Penza Region and the Republic of Kalmykia in 2018, there were no cases of death related with AH. The highest value of the standardized mortality ratio was observed in the Chukotka Autonomous District in 2019 (85.13 per 100,000 population) and the lowest value was observed in the Penza Region (0.14 per 100,000 population). The ratio of maximal to minimal values of the standardized mortality ratio was 622. The coefficient of variation for regional standardized mortality ratios increased by 42.3 % (from 86.8 to 123.5 %).Conclusion Although the standardized mortality ratio for death from AH, in general, decreased in the Russian Federation, Russian regions showed variable dynamics and a high variability of the standardized mortality ratio. The study results together with results of international studies showed that differences in standardized mortality ratios for death from AH are largely due to different approaches to determining the primary cause of death. An international consensus on the terminology and criteria for determining the primary cause of death is required.
Evaluation of the effectiveness of the chronic heart failure therapy using the device cardiac contractility modulation according to the new non-invasive method of the myocardium work analysis
Authors: Dobrovolskaya S. V. , Saidova M. A. , Safiullina A. A. , Uskach T. M. , Tereshchenko S. N. 
Published: January 2022

Aim To analyze echocardiographic parameters that reflect left ventricular (LV) myocardial contractility, using a novel method for evaluation of myocardial performance in patients with chronic heart failure (CHF) and atrial fibrillation (AF) during heart contractility modulation (HCM).Material and methods Standard echocardiographic parameters and indexes of myocardial strain and work were analyzed for 66 patients (52 men and 14 women; median age, 60 [54; 66] years). 36 patients had paroxysmal AF and 30 patients had permanent AF. All patients had CHF with a duration of 17 [4; 60] months; duration of AF was 12 [6; 36] months. At baseline, the left ventricular ejection fraction (LV EF) was 33 [27; 37] %.Results After one year of HCM, LV EF significantly increased from 33 [27; 37] to 38 [33; 44] % (р=0.001). Also, there were improvements in the myocardial global longitudinal strain (from –6.00 [ – 8; – 4] to –8 [ – 10; – 6] %; р=0.001) and parameters of myocardial work, including the global work efficiency (from 74 [65; 79] to 80 [73; 87] mm Hg%; р=0.001), global constructive work (from 699 [516; 940] to 882 [714; 1242] mm Hg%; р=0.001), and global myocardial work index (from 460 [339; 723] to 668 [497; 943] mm Hg%; р=0.001). A segmentary analysis of LV work parameters showed positive changes in the myocardial constructive work in the area of the interventricular septal apical segment (at baseline, 844 [614; 1224]; after HCM, 1027 [800; 1520] mm Hg%; р=0.05) and the medium segment of the LV anteroseptal wall (at baseline, 593 [312; 1000]; after HCM, 877 [494; 1145] mm Hg%; р=0.05).Conclusion This method for analysis of the myocardial work provides a more detailed examination of LV structural and functional remodeling and mechanisms for its effects on the LV contractile function in patients with CHF. This method is promising and merits further study in various clinical situations.
Factors associated with an increase in spatial and frontal QRS-T angles in patients with anterior myocardial infarction
Authors: Sakhnova T. A. , Blinova E. V. , Merkulova I. N. , Shakhnovich R. M. , Zhukova N. S. , Sukhinina T. S. , Barysheva N. A. , Staroverov I. I. 
Published: January 2022

Aim To determine existence of a relationship between any clinical, echocardiographic and coronarographic factors and increased spatial QRS-T (sQRS-T) angle and frontal QRS-T (fQRS-T) angle in patients with anterior myocardial infarction.Material and methods This study included 137 patients aged 62 [53; 72] years with anterior acute myocardial infarction managed at the A.L. Myasnikov Institute of Clinical Cardiology. fQRS-T was calculated as the module of difference between the frontal plane QRS complex axis and the T wave axis. sQRS-T was calculated as a spatial angle between QRS and T integral vectors from a synthesized vectorcardiogram.Results fQRS-T values for a group (median [25th; 75th percentile]) were 81 [37; 120]°; sQRS-T values were 114 [80; 141]°. The correlation coefficient between fQRS-T and sQRS-T values was 0.41 (p<0.001). fQRS-T weakly but statistically significantly correlated with patients’ age (r=0.28; p=0.001), left ventricular ejection fraction (LV EF, r= –0.22; p=0.01), and glomerular filtration rate (r=–0.32; p=0.0002). sQRS-T weakly but statistically significantly correlated with left ventricular end-diastolic dimension (r=0.24; p=0.0048), LV EF (r=–0.28; p=0.0009), and the number of affected segments according to echocardiography data (r=0.27; p=0.002). fQRS-T values were significantly higher in the presence of concurrent arterial hypertension. sQRS-T values were significantly higher in the presence of a history of chronic heart failure. Both fQRS-T and sQRS-T values increased with increasing number of affected blood vessels and Killip class of acute heart failure.Conclusion In patients after anterior acute myocardial infarction, increases in fQRS-T and sQRS-T are associated with more severe damage of the vasculature, decreased LV EF, and, thus, more severe clinical course of disease.
Analysis of undiagnosed neoplasms identified at post-mortem: A descriptive study
Authors: Chaurasia Zini , Agarwal Swapnil , Gupta Renu , Cheta Singh  , Malik Dishant Kumar 
Published: January 2022

Autopsy which is also known as post-mortem examination has been derived from the greek term “autopsia” meaning “to see for one self”. Autopsies performed by the forensic medicine specialists are followed by histopathological examination of various concerned organs for underlying cause of death. histopathological examination of various organs thus always present an interesting plethora of unsuspected findings. These findings could have been present ante mortem with symptoms or completely asymptomatic. The undetectable lesions could have contributed to the death of the person. There fore the alertnesss and inquisitiveness of a pathologist while examining the autopsy cases can contribute significantly towards the subject of pathology and also serve as a learning process for the clinician to establish clinicopathological correlations. This study has been conducted with the following aims & objectives in mind:To analyse the neoplastic lesions detected incidentally on histopathology and correlate with the symptoms if any present ante mortem. Settings and design: this is a retrospective, descriptive study done in the department of pathology, dr. bsa hospital, delhi.A retrospective study of medicolegal autopsies for five years was undertaken in a tertiary care centre to analyse the tumors incidentally detected on histopathological examination. Autopsy records of 663 cases were reviewed and cases where a histopathological diagnosis of tumor was given were included in our study. Gross and histopathologic findings were noted and the salient features were studied. Clinical data of these cases were noted in detail from the forensic post mortem records and tabulated. This study includes 12 cases of tumor out of 663 cases. Most common benign tumor was leiomyoma and most common malignant tumor was adenocarcinoma. An interesting case of hodgkins lymphoma in spleen and liver was also documented. A single case of meningioma, squamous cell carcinoma metastasis to heart and astrocytic tumor were noted.This study highlights the various undetected tumors both benign and malignant. This study also gives a perspective to correlate ante mortem findings with post mortem findings to the clinician and pathologist.
КОНВЕРТАЦІЙНІ ЦЕНТРИ, ЯК ІНСТРУМЕНТ ТІНЬОВОЇ ЕКОНОМІКИ: ВИЗНАЧЕННЯ, ХАРАКТЕРИСТИКА, ШЛЯХИ ПОДОЛАННЯ
Authors: Пеньков С. , Волошина М. 
Published: January 2022

Анотація. Метою статті є загальний аналіз виконання державою своїх соціальних зобов’язань закріплених Конституцією, рівня «тінізації» економіки України, характеристика конвертаційних центрів та схем мінімізації податкових платежів, що застосовуються їх організаторами та учасниками, умов та причин, що унеможливлюють їх знешкодження, пошук шляхів їх усунення, в першу чергу на законодавчому рівні. Проаналізовано сучасний стан наповнюваності державного бюджету України, основні джерела бюджетних надходжень, структуру бюджетних видатків в розрізі виконання соціальних зобов’язань. Визначено високий рівень тіньової економіки, як один з найбільш вагомих чинників, що перешкоджає забезпеченню достатнього рівня соціального захисту населення. Надано характеристику конвертаційних центрів, їх ознаки і структуру, запроваджуваних їх організаторами та учасниками злочинних схем, як одного з інструментів ділків тіньового бізнесу у скоєнні злочинів у сфері господарської діяльності, перш за все ухилення від сплати податків зборів (обов'язкових платежів), легалізації (відмивання) майна, одержаного злочинним шляхом та інших. Запропоновано авторське поняття «конвертаційний центр» для використання у практичній діяльності правоохоронних органів. Поставлено питання щодо визначення на законодавчому рівні поняття «конвертаційний центр» та вирішення питання щодо введення кримінальної відповідальності за організацію їх діяльності. Зроблено висновок про збільшення рівня тіньової економіки України до загрозливого стану, а необхідність боротьби з конвертаційними центрами визначено, як один з пріоритетних напрямків діяльності знов створеного Бюро економічної безпеки України.
Ключові слова: соціальні зобов’язання, бюджет, податкові надходження, конвертаційний центр, тіньова економіка, готівка, фіктивний суб’єкт господарювання.
Формул: 0, рис. 1, табл.: 2 бібл.: 20.
РОЗВИТОК ІНДУСТРІЇ ГОСТИННОСТІ В СУЧАСНИХ УМОВАХ: ТЕНДЕНЦІЇ ТА ЗАХОДИ ПОСИЛЕННЯ КОНКУРЕНТНИХ ПЕРЕВАГ
Authors: Вахович І. , Матвійчук Л. , Смаль Б. 
Published: January 2022

Анотація. Присвячено дослідженню тенденцій розвитку індустрії гостинності в регіонах України. Розглянуто зміст та значення індустрії гостинності в соціально-економічному розвитку регіонів. Визначено зміст досліджуваних дефініцій, узагальнено та сформульовано підходи до визначення співвідношень понять «індустрія гостинності» й «індустрія туризму». Визначено основні показники, що характеризують споживання послуг індустрії гостинності. Доведено що основними такими показниками є внесок індустрії туризму у ВВП, обсяги туристичного збору. Визначено, що стан і розвиток індустрії гостинності характеризують також обсяги капітальних інвестицій за видами економічної діяльності у сфері тимчасового розміщення та організації харчування. Проведено аналіз зазначених показників у динаміці та в регіональному розрізі. Охарактеризовано тенденції розвитку індустрії гостинності в сучасних умовах. Виявлено суттєві регіональні диференціації щодо сплати туристичного збору в Україні, а також зниження майже всіх показників розвитку індустрії гостинності. Проаналізовано дані Всесвітньої ради з подорожей і туризму щодо стану індустрії гостинності в Україні. Виявлено скорочення загального внеску подорожей і туризму в зайнятість України 2020 року до 6,3 %. Визначено напрями і заходи посилення конкурентних переваг індустрії гостинності в регіонах України.
Визначено умови діяльності суб’єктів господарювання індустрії гостинності, до яких віднесено гнучкість і здатність швидко адаптуватися до сучасних умов ринку, упровадження заходів безпеки та гігієни, оптимізації форм підприємницької діяльності, розвиток цифрових технологій, посилення ролі здорового харчування, розширення асортименту продукції та послуг туристичних регіонів, швидкий розвиток послуг доставки, орієнтація на екологічну діяльність, посилення вимоги до кваліфікації персоналу тощо.
Доведено, що перспективними напрямами підвищення конкурентних переваг індустрії гостинності в сучасних умовах є підвищення рівня фінансування галузі, активізація зусиль органів місцевого самоврядування щодо цільового використання коштів від туристичного збору на місцях, а також застосування інструментів стратегування та програмування розвитку індустрії гостинності регіонів, об’єднання стейкхолдерів індустрії в кластери, альянси тощо.
Ключові слова: конкурентні переваги, індустрія гостинності, регіональний розвиток, туристичний збір.
Формул: 0; рис.: 3; табл.: 1; бібл.: 14.
Adult-onset of Langerhans cell histiocytosis: a clinical case
Authors: Chernysheva Olga V. , Dorokhina Olga V. , Khlebnikova Albina N. , Selezneva Elena V. 
Published: January 2022

Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation in adult age is quite uncommon. Skin rashes may be non-specific and mimic a number of dermatoses. Therefore, the clinical diagnosis is challenging and as a rule, such patients are misinterpreted and managed for other disorders by a dermatologist for some years.
We present a clinical case of Langerhans cell histiocytosis with skin involvement in a 35-year female patient, who had been treated by a dermatologist for 2 years for pyoderma, seborrheic dermatitis, and skin fold candidiasis. Taking into account the clinical signs and symptoms and age of manifestation, we initially suspected familial benign pemphigus (Hailey-Hailey disease) or follicular dyskeratosis (Darier's disease). However, the histological assessment showed Langerhans cell histiocytosis confirmed by immunohistochemistry with anti-langerin, anti-CD1a, and anti-protein S-100 antibodies. The patient was referred to a hematologist for further work-upand specific treatment.
In cases of any treatment resistant disorders, which do not respond to long-term conventional treatment, it is necessary to reconsider the diagnosis by means of histological investigation. It would allow for identification of a disease, which is uncommon in dermatology practice.
INFORMATION AND COMMUNICATION TECHNOLOGY: MENDORONG EFISIENSI KINERJA AUDITOR SELAMA PANDEMI COVID-19
Authors: Nabila Khansaa , Sasmita Maulidya Eka , Adawiyah Robbiatul , Putri Dhika Maha 
Published: January 2022

The evolution of information technology is going rapidly, supported by the COVID-19 pandemic where all activities related to face-to-face and gathering activities are limited. Many companies already have implemented ‘work from home’ policies for their employees, including auditors. Responding to this phenomenon, many companies have finally changed the auditor’s work system by applying remote audit techniques based on the use of ICT tools.The application of Information and Communication Technology (ICT) will minimize direct contact, and also reduce audit. The purpose of this study is to examine the effectiveness and efficiency of auditor's performance by applying remote audit techniques using ICT. In this study uses a qualitative approach. By to obtain a depth understanding of the object of research related to the existing problems such as the risks and to find out whether the application of ICT in remote audit techniques is effective and efficient when it’s carried out during a pandemic. A literature study is employed to assess the efficiency of ICT performance in remote audit techniques. The results of this study indicate that the application of ICT in supporting the remote audit process during the Covid-19 pandemic is the best way. However, we should still paying attention to the appropriateness of the devices, the signal, and data security protection so that the evidences provided by the auditee to the auditors are remains usable and reliable.
UNSUR INTRINSIK NOVEL "AROMA KARSA" KARYA DEE LESTARI DAN PEMANFAATANNYA SEBAGAI MATERI AJAR SASTRA DI KELAS XII SMA
Authors: Wibowo Bagus Juniarto , Andayani Andayani , Hastuti Sri 
Published: January 2022

<p>Penelitian ini bertujuan untuk mendeskripsikan (1) unsur intrinsik (alur, tema, amanat, tokoh dan penokohan, latar, serta sudut pandang) pada novel <em>Aroma Karsa</em> karya Dee Lestari; (2) hubungan antarunsur intrinsik pada novel <em>Aroma Karsa</em> karya Dee Lestari; (3) pemanfaatan analisis struktural pada novel <em>Aroma Karsa</em> karya Dee Lestari sebagai materi ajar sastra kelas XII SMA. Jenis penelitian ini adalah penelitian deskriptif kualitatif, menggunakan pendekatan struktural sastra. Sumber data dalam penelitian ini adalah dokumen novel <em>Aroma Karsa</em> karya Dee Lestari. Teknik pengambilan sampel menggunakan metode <em>purposive sampling</em>. Teknik pengumpulan_data yang digunakan yaitu dengan cara analisis dokumen dan wawancara. Peneliti menggunakan triangulasi teori dan sumber data sebagai uji validitas data. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik analisis model interaktif. <strong> </strong>Hasil penelitian ini dapat dikemukakan bahwa 1) terdapat unsur intrinsik novel <em>Aroma Karsa</em> karya Dee Lestari meliputi tema, alur, penokohan, latar, sudut pandang, dan amanat; 2) Setiap unsur yang terdapat dalam novel <em>Aroma Karsa</em> karya Dee Lestari memiliki hubungan dan tidak dapat berdiri sendiri; 3) Novel <em>Aroma Karsa</em> karya Dee Lestari dapat dimanfaatkan sebagai materi ajar sastra kelas XII SMA pada KD 3.9 menggunakan metode <em>Jigsaw, Talking Sticking</em> dan lain-lain.</p><p> </p>
Pre-treatment and continuous administration of simvastatin during sepsis improve metabolic parameters and prevent CNS injuries in survivor rats
Authors: Catalão Carlos Henrique Rocha , Souza Anderson de Oliveira , Santos-Junior Nilton Nascimento , Costa Luis Henrique Angenendt da , Santos Jonathas Rodrigo dos , Alberici Luciane Carla , Rocha Maria José Alves 
Published: January 2022

Abstract
Sepsis causes overproduction of inflammatory cytokines, organ dysfunction and cognitive impairment in survivors. In addition to inflammation, metabolic changes occur according to the stage and severity of the disease. Understanding the role and place of metabolic disturbances in the pathophysiology of sepsis is essential to evaluate the framework of septic patients, predict the syndrome progress and define treatment strategies. We investigated the effect of simvastatin on the disease time course and on metabolic alterations, especially with respect to their possible consequences in the CNS of surviving rats. The animals of this study were weighed daily and followed for 10 days to determine the survival rate. In the first experiment, control or CLP-animals were randomized in 24 h, 48 h and 10 days after septic induction, for bacterial load determination and, quantification of cytokines. In the second experiment, control or CLP-animals were treated or not with simvastatin and randomized in the same three time points for cytokines quantification and assessment of their body metabolism and locomotor activity (at 48 h and 10 days), as well as the evaluation of cytoarchitecture and astrogliosis (at 10 days). The CLP-rats treated with simvastatin showed a reduction in plasma cytokines and improvement in metabolic parameters and locomotor activity, followed by minor alterations compatible with apoptosis and astrogliosis in the hippocampus and prefrontal cortex. These results suggest that the anti-inflammatory effect of simvastatin plays a crucial role in restoring energy production, maintaining a hypermetabolic state necessary for the recovery and survival of these CLP-rats.
Antibacterial Activity and Phytochemical Screening of Leaf Extracts of Sida acuta From North-Central Nigeria.
Authors: Oluleye Isaac Olubunmi , Folahan Faith Feranmi , Nnabuike Chukwuemeka Prince , Ahmed Motolani Mohammed 
Published: January 2022

Abstract
This study was carried out to examine the antibacterial activity and phytochemical compositions of extracts from the leaf of Sida acuta . Using water and 70% ethanol, active components of Sida acuta were extracted and tested against six authenticated clinical isolates: Eschericia coli , Pseudomonas aeruginosa , Bacillus subtilis , Staphylococcus aureus , Klebsiella pneumoniae and Salmonella typhi .
The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of extracts were determined using broth dilution and recovery plate methods respectively, while Thin Layer Chromatography (TLC) and Gas Chromatography Mass Spectrometry (GC-MS) were used in determining the presence and quantity of phytochemicals in the extracts.
All clinical isolates, except P. aeruginosa , were markedly susceptible to Sida acuta leaf extracts, with inhibition zones ranging from 6.0mm to 20.0mm. The least MIC (3.13 mg/ml) and MBC (3.13 mg/ml) was observed in ethanolic leaf extract against S. aureus , while the highest (150 mg/ml and 150.00mg/ml) were observed in the ethanolic leaf extract against K. pneumoniae .
Phytochemical tests identified flavonoids as the most dominant compound while tannins was the least. TLC analysis showed Rf values ranging from 0.10 to 0.98, while the GC-MS identified scopoletin (45.8%) and vomifoliol (41.0%) as the most abundant compounds from the aqueous extract. Evofolin-A, 4-ketopinoresinol, assamicin I and assamicin II were also observed from the leaf extracts.
The findings of this study reveals the potency of Sida acuta leaf extracts as an antibacterial, thus suggesting its possible use in treating common infections as well as a potential candidate for further research on antibacterial therapeutics.
Keywords: Sida acuta , leaf extracts, antibacterial, phytochemicals, scopoletin, vomifoliol.