bluuebunny/crossref_metadata_2025_split huggingface dataset:
A population-based retrospective study of the modifying effect of urban blue space on the impact of socioeconomic deprivation on mental health, 2009–2018
Authors: Georgiou Michail , Tieges Zoë , Morison Gordon , Smith Niamh , Chastin Sebastien 
Published: July 2022

AbstractThe incidence of mental health disorders in urban areas is increasing and there is a growing interest in using urban blue spaces (urban waterways, canals, lakes, ponds, coasts, etc.) as a tool to manage and mitigate mental health inequalities in the population. However, there is a dearth of longitudinal evidence of the mechanisms and impact of blue spaces on clinical markers of mental health to support and inform such interventions. We conducted a 10-year retrospective study, following STROBE guidelines, using routinely collected population primary care health data within the National Health Service (NHS) administrative area of Greater Glasgow and Clyde for the North of Glasgow city area. We explored whether living near blue space modifies the negative effect of socio-economic deprivation on mental health during the regeneration of an urban blue space (canal) from complete dereliction and closure. A total of 132,788 people (65,351 female) fulfilling the inclusion criteria were entered in the analysis. We established a base model estimating the effect of deprivation on the risk of mental health disorders using a Cox proportional hazards model, adjusted for age, sex and pre-existing comorbidities. We then investigated the modifying effect of living near blue space by computing a second model which included distance to blue space as an additional predicting variable and compared the results to the base model. Living near blue space modified the risk of mental health disorders deriving from socio-economic deprivation by 6% (hazard ratio 2.48, 95% confidence interval 2.39–2.57) for those living in the most deprived tertile (T1) and by 4% (hazard ratio 1.66, 95% confidence interval 1.60–1.72) for those in the medium deprivation tertile (T2). Our findings support the notion that living near blue space could play an important role in reducing the burden of mental health inequalities in urban populations.
Multiparametric cloth-based wearable, SimpleSense, estimates blood pressure
Authors: Kumar Prashanth Shyam , Rai Pratyush , Ramasamy Mouli , Varadan Venkatesh K. , Varadan Vijay K. 
Published: July 2022

AbstractTargeted maintenance of blood pressure for hypertensive patients requires accurate monitoring of blood pressure at home. Use of multiparametric vital signs ECG, heart sounds, and thoracic impedance for blood pressure estimation at home has not been reported previously. In an observational multi-site study, 120 subjects (female (N = 61, 52%)) between 18 and 83 years of age were recruited with the following stratification (Normal (20%), prehypertensive (37%), stage 1(26%), and stage 2 (18%). From these subjects, 1686 measurements of blood pressure from a sphygmomanometer were associated with simultaneously acquired signals from the SimpleSense device. An ensemble of tree-based models was trained with inputs as metrics derived from the multiparametric and patient demographics data. A test Mean Absolute Difference (MAD) of ± 6.38 mm of Hg and ± 5.10 mm of Hg were obtained for systolic and diastolic blood pressures (SBP; DBP), respectively. Comparatively, the MAD for wrist-worn blood pressure cuff OMRON BP6350 (GUDID—10073796266353) was ± 8.92 mm of Hg and ± 6.86 mm of Hg, respectively. Machine learning models trained to use multiparametric data can monitor SBP and DBP without the need for calibration, and with accuracy levels comparable to at-home cuff-based blood pressure monitors.
Unlocking the access to oxidized coenzyme A via a single-step green membrane-based purification
Authors: Mouterde Louis M. M. , Willig Gaëlle , Langlait Maxime M. J. , Brunois Fanny , Chadni Morad , Allais Florent 
Published: July 2022

AbstractA new membrane-based strategy to purify oxidized coenzyme A ((CoAS)2) from adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) has been developed. Commercially available membranes were screened and studied (permeate flux and overall compounds retention) which allowed the identification of one efficient membrane (GK from Suez Water Technologies & Solutions). Different total compounds concentrations solutions were used in the system in order to find the following working conditions: 4 bars with a total compounds solution of 5.19 g L−1. Applying these conditions to a dia-filtration set-up allowed us to reach 68% pure (CoAS)2 in 4.8 diafiltration volumes (DV) and a 95% (CoAS)2 purity can be predicted in 8.5 DV. A comparative study of green metrics—i.e. process mass index (PMI)—of the classic chromatography vs the membrane-based one demonstrated the great advantages of the latter in terms of sustainability. This strategy unlocks the access to the essential and central cofactor that is coenzyme A.
Association between a dietary pattern high in saturated fatty acids, dietary energy density, and sodium with coronary heart disease
Authors: Abu Bakar Nur Ain Fatinah , Ahmad Aryati , Wan Musa Wan Zulaika , Shahril Mohd Razif , Wan-Arfah Nadiah , Abdul Majid Hazreen , Piernas Carmen , Ramli Ahmad Wazi , Naing Nyi Nyi 
Published: July 2022

AbstractThis study aimed to determine the association between dietary pattern (DP) and coronary heart disease (CHD) among high-risk adults as determined by metabolic syndrome (MetS) criteria in Malaysia. This cross-sectional study involved 365 participants with (CHD = 178; non-CHD = 187) who were recruited from selected health clinics. Dietary intake was measured using a 189-item semi-quantitative foods frequency questionnaire (FFQ) whilst anthropometry and clinical data were measured by trained researcher and biochemical data were obtained from medical records. The reduced rank regression (RRR) method was used to derive DPs scores and binary logistic regression was used to assess the associations between identified DPs and CHD. The main DP found in this study was characterised by “high saturated fatty acid (SFA), high dietary energy density (DED), high sodium”. This DP, which is attributed to high consumption of coconut-based dishes, fast foods and snacks, rice dishes, fat spread, seasoning sauces, salted and processed foods, and low intake of fruits, green leafy vegetables, white rice and other vegetables were associated with CHD (OR:1.32, 95% CI:1.03, 1.69) p value = 0.026 when, adjusted for age, sex, race, education level, household income, family history of CHD, marital status, smoking status, physical activity, stress level and BMI. This study suggests that individuals with a DP of high SFA, high DED, and high sodium have a significantly increased likelihood of having CHD compared to those who do not practice this DP.
Spatiotemporal changes in influenza A virus prevalence among wild waterfowl inhabiting the continental United States throughout the annual cycle
Authors: Kent Cody M. , Ramey Andrew M. , Ackerman Joshua T. , Bahl Justin , Bevins Sarah N. , Bowman Andrew S. , Boyce Walter M. , Cardona Carol J. , Casazza Michael L. , Cline Troy D. , E. De La Cruz Susan , Hall Jeffrey S. , Hill Nichola J. , Ip Hon S. , Krauss Scott , Mullinax Jennifer M. , Nolting Jacqueline M. , Plancarte Magdalena , Poulson Rebecca L. , Runstadler Jonathan A. , Slemons Richard D. , Stallknecht David E. , Sullivan Jeffery D. , Takekawa John Y. , Webby Richard J. , Webster Robert G. , Prosser Diann J. 
Published: July 2022

AbstractAvian influenza viruses can pose serious risks to agricultural production, human health, and wildlife. An understanding of viruses in wild reservoir species across time and space is important to informing surveillance programs, risk models, and potential population impacts for vulnerable species. Although it is recognized that influenza A virus prevalence peaks in reservoir waterfowl in late summer through autumn, temporal and spatial variation across species has not been fully characterized. We combined two large influenza databases for North America and applied spatiotemporal models to explore patterns in prevalence throughout the annual cycle and across the continental United States for 30 waterfowl species. Peaks in prevalence in late summer through autumn were pronounced for dabbling ducks in the generaAnasandSpatula, but notMareca. Spatially, areas of high prevalence appeared to be related to regional duck density, with highest predicted prevalence found across the upper Midwest during early fall, though further study is needed. We documented elevated prevalence in late winter and early spring, particularly in the Mississippi Alluvial Valley. Our results suggest that spatiotemporal variation in prevalence outside autumn staging areas may also represent a dynamic parameter to be considered in IAV ecology and associated risks.
Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients
Authors: Nakamura Kimihiko , Isoyama Naohito , Nakayama Yuki , Hiroyoshi Toshiya , Fujikawa Koki , Miura Yutaka , Kurosu Hiroshi , Matsuyama Hideyasu , Kuro-o Makoto 
Published: July 2022

AbstractCalciprotein particles (CPPs) are circulating colloidal mineral-protein complexes containing crystalline and/or non-crystalline (amorphous) calcium-phosphate (CaPi). Serum CPP levels correlate with vascular stiffness and calcification in patients with chronic kidney disease (CKD). In vitro studies showed that CPPs containing crystalline CaPi were more arteriosclerogenic and inflammogenic than CPPs without containing crystalline CaPi. Thus, we hypothesized that not only the quantity but also the quality of CPPs (the phase of CaPi) might affect clinical outcomes. To test this hypothesis, we quantified amorphous CaPi ratio defined as the ratio of the amorphous CaPi amount to the total CaPi amount in serum CPPs from 183 hemodialysis patients and explored its possible correlation with serum parameters associated with prognosis of hemodialysis patients. Multivariate analysis revealed that the amorphous CaPi ratio correlated positively with hemoglobin and negatively with fibroblast growth factor-21 (FGF21), which remained significant after adjusting for the total CaPi amount. Because low hemoglobin and high FGF21 are associated with increased mortality, the present study warrants further studies to determine whether low amorphous CaPi ratio in circulating CPPs may be associated with poor prognosis in hemodialysis patients.
Diurnal changes of noninvasive parameters of ocular surface in healthy subjects before and after continuous face mask wearing during the COVID-19 pandemic
Authors: Giannaccare Giuseppe , Pellegrini Marco , Borselli Massimiliano , Senni Carlotta , Bruno Angela , Scorcia Vincenzo 
Published: July 2022

AbstractTo investigate whether diurnal changes in noninvasive ocular surface parameters and subjective symptoms occur in healthy subjects wearing face mask who were analyzed before and after 8 h of continuous use. In this prospective cross-sectional study, healthy volunteers attending the same workplace environment underwent a noninvasive ocular surface workup by means of Keratograph 5 M (Oculus, Wetzlar, Germany) in the same day at 2 different time points: (i) in the early morning before wearing face mask (T0); (ii) after 8 h of continuous face mask use (T1). Noninvasive break-up time (NIBUT), tear meniscus height (TMH), ocular redness and meibomian gland dropout were measured. All subjects were asked to complete the Ocular Surface Disease Index (OSDI) questionnaire before and after 8 h of face mask wearing. Data from 20 healthy subjects (10 males and 10 females, mean age 25.1 ± 3.9 years) were included. Mean value of TMH decreased significantly from 0.29 ± 0.07 at T0 to 0.23 ± 0.07 mm at T1 (P < 0.001); conversely, mean values of NIBUT, redness score and meibomian gland dropout did not change significantly after continuous face mask wearing (alwaysP > 0.532). Concerning ocular discomfort symptoms, mean value of OSDI score worsened significantly at T1 compared to T0 (from 12.9 ± 12.6 to 19.4 ± 12.0;P = 0.017). Continuous face mask wearing for 8 h led to decreased TMH associated with the onset of ocular discomfort symptoms in young healthy subjects.
Paradoxical effects of altruism on efforts to mitigate climate change
Authors: Fossas-Tenas A. , Ibelings B. W. , Kasparian J. , Krishnakumar J. , Laurent-Lucchetti J. 
Published: July 2022

AbstractIt is common wisdom that altruism is a crucial element in addressing climate change and other public good issues. If individuals care about the welfare of others (including future generations) they can be expected to unilaterally adapt their behaviour to preserve the common good thus enhancing the wellbeing of all. We introduce a network game model featuring both altruism and a public good (e.g. climate) whose degradation affects all players. As expected, in an idealistic fully connected society where all players care about each other, increasing altruism results in a better protection of the public good. However, in more realistic networks where people are not all related to each other, we highlight an intrinsic trade-off between the effects of altruism on reducing inequality and the preservation of a global public good: the consumption redistribution generated by a higher altruism is partly achieved by lowering income transfers towards protection of the public good. Therefore, it increases overall consumption and is thereby detrimental to the public good. These results suggest that altruism, although good from a welfarist point of view, is not in itself sufficient to simultaneously solve public good and inequality issues.
Applying the concept of liquid biopsy to monitor the microbial biodiversity of marine coastal ecosystems
Authors: Ferchiou Sophia , Caza France , de Boissel Philippine Granger Joly , Villemur Richard , St-Pierre Yves 
Published: July 2022

Abstract
Liquid biopsy (LB) is a concept that is rapidly gaining ground in the biomedical field. Its concept is largely based on the detection of circulating cell-free DNA (ccfDNA) fragments that are mostly released as small fragments following cell death in various tissues. A small percentage of these fragments are from foreign (nonself) tissues or organisms. In the present work, we applied this concept to mussels, a sentinel species known for its high filtration capacity of seawater. We exploited the capacity of mussels to be used as natural filters to capture environmental DNA fragments of different origins to provide information on the biodiversity of marine coastal ecosystems. Our results showed that hemolymph of mussels contains DNA fragments that varied considerably in size, ranging from 1 to 5 kb. Shotgun sequencing revealed that a significant amount of DNA fragments had a nonself microbial origin. Among these, we found DNA fragments derived from bacteria, archaea, and viruses, including viruses known to infect a variety of hosts that commonly populate coastal marine ecosystems. Taken together, our study shows that the concept of LB applied to mussels provides a rich and yet unexplored source of knowledge regarding the microbial biodiversity of a marine coastal ecosystem.
Detection of an unidentified soft X-ray emission feature in NGC 5548
Authors: Gu Liyi , Mao Junjie , Kaastra Jelle S. , Mehdipour Missagh , Pinto Ciro , Grafton-Waters Sam , Bianchi Stefano , Landt Hermine , Branduardi-Raymont Graziella , Costantini Elisa , Ebrero Jacobo , Petrucci Pierre-Olivier , Behar Ehud , di Gesu Laura , De Marco Barbara , Matt Giorgio , Mitchell Jake A. J. , Peretz Uria , Ursini Francesco , Ward Martin 
Published: July 2022

Context.NGC 5548 is an X-ray bright Seyfert 1 active galaxy. It exhibits a variety of spectroscopic features in the soft X-ray band, in particular including the absorption by the active galactic nucleus (AGN) outflows of a broad range of ionization states, with column densities up to 1027m−2, and having speeds up to several thousand kilometers per second. The known emission features are in broad agreement with photoionized X-ray narrow and broad emission line models.Aims.We report on an X-ray spectroscopic study using 1.1 MsXMM-Newtonand 0.9 MsChandragrating observations of NGC 5548 spanning two decades. The aim is to search and characterize any potential spectroscopic features in addition to the known primary spectral components that are already modeled in high precision.Methods.For each observation, we modeled the data using a global fit including an intrinsic spectral energy distribution of the AGNs and the known distant X-ray absorbers and emitters. We utilized as much knowledge from previous studies as possible. The fit residuals were stacked and scanned for possible secondary features.Results.We detect a weak unidentified excess emission feature at ∼18.4 Å (18.1 Å in the restframe). The feature is seen at > 5σstatistical significance taking the look-elsewhere effect into account. No known instrumental issues, atomic transitions, or astrophysical effects can explain this excess. The observed intensity of the possible feature seems to anticorrelate in time with the hardness ratio of the source. However, even though the variability might not be intrinsic, it might be caused by the time-variable obscuration by the outflows. An intriguing possibility is the line emission from charge exchange between a partially ionized outflow and a neutral layer in the same outflow, or in the close environment. Other possibilities, such as emission from a highly ionized component with high outflowing speed, cannot be fully ruled out.
Correlation of Trigeminopontine Angle with Severity of Trigeminal Neuralgia due to Neurovascular Conflict over Medial Aspect of Nerve: Can We Prognosticate the Reduction in Pain in Patients on Medical Management?
Authors: Lamani Pundalik Umalappa , Arora Abhishek J. , Kona Kiran Kumar Reddy , Yarlagadda Jyotsna 
Published: August 2022

Abstract
Background Neurovascular conflicts (NVCs) are one of the major causative factors in patients presenting with trigeminal neuralgia (TN). We found a wide range of variation in degrees of acute angle formed between medial border of trigeminal nerve and anterior border of pons in patients with TN, i.e., medial trigeminopontine angle (mTPA), and tried to find its correlation with pain severity due to NVC over the medial aspect of nerve (mNVC).
Aims and Objectives To correlate mTPA measurement with severity of TN due to mNVC. To calculate the reduction in pain in patients kept on medical management and its correlation with mTPA.
Materials and Methods This was a retrospective observational study conducted between May 2018 and October 2020. A total of 41 patients presenting with TN and showing corresponding NVC were included in the study. Out of the total cases with NVC, 30 cases showed NVC over the medial surface of the nerve. All the patients were evaluated on MAGNETOM Skyra 3T magnetic resonance imaging (MRI; Siemens). Using the two-line Cobb angle method, the trigeminopontine angle was calculated. Pretreatment pain intensity and posttreatment pain relief of each patients were assessed by using the numeric rating scale (NRS) with numbers from 0 to 10 (“no pain” to “worst pain imaginable”). Relevant clinical details regarding pre- and posttreatment pain score, after a standard treatment plan of 600 mg of oxcarbazepine for 2 weeks, were collected.
Results Patients showing response of more than or equal to 50% (≥50%) are considered as “good response” and those with response of less than 50% (<50%) are considered as “poor response.” In our study with trigeminopontine angle threshold of 45 degrees, 7 out of 8 (87.5%) patients with >45° mTPA showed poor response and 15/22 (68.2%) patients with ≤45° showed good response to medical management for TN with statistical significance difference with a p-valve of 0.007.
Conclusion We found a negative correlation between the mTPA and percentage pain relief in patients kept on medical management and realized that mTPA measurement could become an important tool for prognosticating pain relief for patients of TN on medical therapy; however, more evidence and multicentric studies are required for the same.
Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy
Authors: Bhatt Shuchi , Mandal Samrat , Mehrotra Gopesh , Arora Vipin , Singh Usharani 
Published: August 2022

Abstract
Background Computed tomography perfusion (CTp), a useful technique in oncology, is not widely utilized due to the high radiation dose delivered from it. It involves scanning the region of interest every second for 50 seconds following intravenous contrast administration. Doubling sampling interval (SI) to 2 seconds will half the radiation dose, but may impact its effectiveness, which needs to be evaluated.
Objectives To evaluate a dose reduction strategy in CTp by determining agreement between standard dose (SD) CTp (acquisition with SI 1 second) and low-dose CTp techniques with SI of 2 seconds (achieved either by reconstruction only or true low-dose acquisition).
Materials and methods This cross-sectional study was conducted on histopathology-proven head and neck squamous cell carcinoma (HNSCC) patients who underwent CTp on 64 slice multidetector CT. A total of 56 patients had SD and 24 patients underwent true low dose (LD) acquisition. SD data were also reconstructed at SI 2 seconds to obtain a dataset simulating low dose (low-dose reconstruction [LDr]). Paired t-test was applied to compare CTp in SD and LDr groups and the Bland–Altman plot drawn to calculate 95% confidence limit of agreement. The Kolmogorov–Smirnov test compared CTp parameters for LDr and LD groups.
Results There was no statistical difference in CTp parameters (except blood flow in malignant) in SD and LDr groups for both malignant and normal tissues. CTp of malignant tissue was not statistically different in LDr and LD groups but the radiation dose was half in the LD group.
Conclusion Reduction of radiation dose to half achieved by doubling the SI does not affect the CTp parameters significantly. So LD acquisitions will increase the use of CTp in HNSCC.
Study on jet characteristics of a dual-structure converter oxygen lance based on hydrodynamics
Authors: Jia Hongbin , Li Yanxin , Liu Kun , Feng Lianghua 
Published: July 2022

Oxygen lance is the key piece of equipment for iron and steel smelting. During the entire steelmaking process, the performance of the oxygen lance determines the occurrence of decarburization, slagging, heating, and splashing. In this paper, the influence of structural and process parameters on converter steelmaking is studied using a six-nozzle staggered oxygen lance and the traditional six-nozzle oxygen lance by performing jet tests, numerical simulation, and water model experiments. The research results show that, compared with the traditional oxygen lance nozzle, a stepwise fusion of the jet streams of the staggered oxygen lance nozzles occurs, which increases the fusion distance to varying degrees, reduces the amount of splash at the furnace mouth, and increases the effective impact area. For the six-nozzle staggered oxygen lance nozzle, the most ideal structure and maximum performance are obtained at an inner nozzle angle of 14° with a flow ratio of 55% and an outer nozzle angle of 18° with a flow ratio of 45%. The results show that the fusion distance of the inner nozzle and outer nozzle is 2.1 and 2.25 m, respectively; compared to the traditional oxygen lance nozzle, the splash amount of 0.19 g at the furnace mouth is reduced to only 16%, while the effective impact area has doubled to reach a value of 0.47 m2. With the increase in the oxygen lance position, the effective impact area of the jet of the oxygen lance nozzle on the molten pool first increases and then decreases, and the best position of the traditional and staggered oxygen lance nozzles is determined as 30.0 and 35.0–37.5 de, respectively.