bluuebunny/crossref_metadata_2025_split huggingface dataset:
An antibody‐free enrichment approach enabled by reductive glutaraldehydation for monomethyllysine proteome analysis
Authors: Li Zhouxian , Wang Qi , Wang Keyun , Zhang Weibing , Ye Mingliang 
Published: May 2022

AbstractProtein lysine monomethylation is an important post‐translational modification participated in regulating many biological processes. There is growing interest in identifying these methylation events. However, the introduction of one methyl group on lysine residues has negligible effect on changing the physical and chemical properties of proteins or peptides, making enriching and identifying monomethylated lysine (Kme1) proteins or peptides extraordinarily challenging. In this study, we proposed an antibody‐free chemical proteomics approach to capture Kme1 peptides from complex protein digest. By exploiting reductive glutaraldehydation, 5‐aldehyde‐pentanyl modified Kme1 residues and piperidine modified primary amines were generated at the same time. The peptides with aldehyde modified Kme1 residues were then enriched by solid‐phase hydrazide chemistry. This chemical proteomics approach was validated by using several synthetic peptides. It was demonstrated that it can enrich and detect Kme1 peptide from peptide mixture containing 5000‐fold more bovine serum albumin tryptic digest. Besides, we extended our approach to profile Kme1 using heavy methyl stable isotope labeling by amino acids in cell culture (hmSILAC) labeled Jurkat T cells and Hela cells. Totally, 29 Kme1 sites on 25 proteins were identified with high confidence and 11 Kme1 sites were identified in both two types cells. This is the first antibody‐free chemical proteomics approach to enrich Kme1 peptides from complex protein digest, and it provides a potential avenue for the analysis of methylome.
Stabilization of a class of stochastic nonlinear systems using a bang‐bang controller
Authors: Barbata Asma , Zasadzinski Michel , Souley Ali Harouna 
Published: May 2022

AbstractIn this article, a bang‐bang control strategy is proposed to almost surely exponentially stabilize a class of nonlinear stochastic systems driven by multiplicative noises. Two cases are considered: first, a state feedback control if the whole state is measured and, second, an observer‐based feedback control if the state is partially measured.
Model-free data-driven simulation of inelastic materials using structured data sets, tangent space information and transition rules
Authors: Ciftci Kerem , Hackl Klaus 
Published: May 2022

AbstractModel-free data-driven computational mechanics replaces phenomenological constitutive functions by numerical simulations based on data sets of representative samples in stress-strain space. The distance of strain and stress pairs from the data set is minimized, subject to equilibrium and compatibility constraints. Although this method operates well for non-linear elastic problems, there are challenges dealing with history-dependent materials, since one and the same point in stress-strain space might correspond to different material behaviour. In recent literature, this issue has been treated by including local histories into the data set. However, there is still the necessity to include models for the evolution of specific internal variables. Thus, a mixed formulation of classical and data-driven modeling is obtained. In the presented approach, the data set is augmented with directions in the tangent space of points in stress-strain space. Moreover, the data set is divided into subsets corresponding to different material behaviour. Based on this classification, transition rules map the modeling points to the various subsets. The approach will be applied to non-linear elasticity and elasto-plasticity with isotropic hardening.
Methodological approach to spatial analysis of agricultural pest dispersal in olive landscapes
Authors: Moreno A. , Rescia A. J. , Pascual S. , Ortega M. 
Published: May 2022

Abstract
The effectiveness of a Geographical Information Systems cost-distance tool for detecting landscape permeability in relation to the movement of pests in olive landscapes was established. The simplification of agricultural systems is linked to an increased incidence of pests on crops. Therefore, it is important to understand the impact of different land uses surrounding olive groves on pests. In this work, we analysed the effect of the structure of the olive landscape on the movement of two main olive pests—the olive fruit fly, Bactrocera oleae (Rossi) (Diptera: Tephritidae) and the olive moth, Prays oleae (Bernard) (Lepidopetera: Praydidae). We applied linear mixed effects models to analyse the relationship between pest abundance and cost-distance, using different hypotheses to evaluate those land uses that are favourable or unfavourable for the movement of these pests. The results show that this methodology is effective in detecting possible unfavourable land uses with a barrier effect, such as woodland and artificial land uses, and favourable land uses with a corridor effect such as olive groves. Whether other land uses, such as scrubland or riverbanks, act as a barrier or corridor depends on the pest and its life cycle stage. The effect that different land uses have in maintaining low levels of pest populations and ensuring the long-term sustainability of these agricultural systems are discussed. The implications of landscape permeability for the physical structure of the landscape and the dispersal of organisms, and the potential of that landscape to impact the continuous flow of natural processes are also addressed.
Five-dimensional gauge theories and the local B-model
Authors: Brini Andrea , Osuga Kento 
Published: May 2022

AbstractWe propose an effective framework for computing the prepotential of the topological B-model on a class of local Calabi–Yau geometries related to the circle compactification of five-dimensional $$\mathcal {N}=1$$

N
=
1

super Yang–Mills theory with simple gauge group. In the simply laced case, we construct Picard–Fuchs operators from the Dubrovin connection on the Frobenius manifolds associated with the extended affine Weyl groups of type $$\mathrm {ADE}$$
ADE
. In general, we propose a purely algebraic construction of Picard–Fuchs ideals from a canonical subring of the space of regular functions on the ramification locus of the Seiberg–Witten curve, encompassing non-simply laced cases as well. We offer several precision tests of our proposal for simply laced cases by comparing with the gauge theory prepotentials obtained from the K-theoretic blow-up equations, finding perfect agreement. Whenever there is more than one candidate Seiberg-Witten curve for non-simply laced gauge groups in the literature, we employ our framework to verify which one agrees with the K-theoretic blow-up equations.
Citizen Science in Deliberative Systems: Participation, Epistemic Injustice, and Civic Empowerment
Authors: Herzog Lisa , Lepenies Robert 
Published: May 2022

AbstractIn this paper, we bring together the literature on citizen science and on deliberative democracy and epistemic injustice. We argue that citizen science can be seen as one element of “deliberative systems,” as described by Mansbridge et al. But in order to fulfil its democratic potential, citizen science needs to be attentive to various forms of exclusion and epistemic injustice, as analyzed by Fricker, Medina and others. Moreover, to tap the potentials of citizen science from the perspective of deliberative democracy, it needs to move towards a more empowered approach, in which citizens do not only deliver data points, but also, in invited or uninvited settings, participate in discussions about the goals and implications of research. Integrating citizen science into the deliberative systems approach embeds it in a broader framework of democratic theory and suggests the transmission of certain practical strategies (e.g., randomized sampling). It can also contribute to realism about both the potentials and the limits of citizen science. As part of a deliberative system, citizen science cannot, and need not, be the only place in which reforms are necessary for creating stronger ties between science and society and for aligning science with democratic values.
Improving the efficiency counting of Cherenkov detector by using high transmittance photonic crystal materials
Authors: El-Shemy Shimaa , Eissa M. F. , Sayed Hassan , Alrakshy M. F. , Matar Z. S. , Aly Arafa H. 
Published: May 2022

AbstractIn this study, a new type of photonic crystal (PC) designed as a transmitter. The transmittance spectra of the one-dimensional (1D) photonic crystal which are consist of silicon dioxide/magnesium fluoride (SiO2/MgF2). We are simulated the results using different incident angles, and the results showed a high transmittance (99.5%) within the wavelength range of (200–700 nm). Simulations of two-dimensional (2D) photonic crystals were studied, as well as the transmittance values were investigated. As a transmitter, photonic crystals in a one-dimensional array of SiO2 and MgF2 with periodicities N = 5 were employed around the wall of the Cherenkov counter vial. The high transmittance of the SiO2/MgF2 PC allows Cherenkov light to pass without any losing in its initial incident intensity which improves the Cherenkov counting efficiency, which is utilized in a wide range of applications. By replacing the traditional polyethylene (generally used to fabricate the walls of the counter vial) with the high transmittance photonic crystal SiO2/MgF2 which is allow to the most of the emitted Cherenkov radiation to reach the photomultiplier tube without any losing in its way to the tube. Subsequently, the efficiency of the Cherenkov counter was improved. Comparing the counting efficiency for both the polyethylene and the SiO2/MgF2 photonic crystal, it was found that the counting efficiency will be increased by 15% in one-dimension and 9.5% in two-dimensions if the polyethylene walls of the vial were replaced by SiO2/MgF2.
The Dirichlet Problem for p-minimizers on Finely Open Sets in Metric Spaces
Authors: Björn Anders , Björn Jana , Latvala Visa 
Published: May 2022

AbstractWe initiate the study of finep-(super)minimizers, associated withp-harmonic functions, on finely open sets in metric spaces, where$1 < p < \infty $1<p<∞. After having developed their basic theory, we obtain thep-fine continuity of the solution of the Dirichlet problem on a finely open set with continuous Sobolev boundary values, as a by-product of similar pointwise results. These results are new also on unweightedRn. We build this theory in a complete metric space equipped with a doubling measure supporting ap-Poincaré inequality.
Remembering James Barber (1940–2020)
Authors: Nixon Peter J. , Telfer Alison 
Published: May 2022

AbstractJames Barber, known to colleagues and friends as Jim, passed away in January 2020 after a long battle against cancer. During his long and distinguished career in photosynthesis research, Jim made many outstanding contributions with the pinnacle achieving his dream of determining the first detailed structure of the Mn cluster involved in photosynthetic water oxidation. Here, colleagues and friends remember Jim and reflect upon his scientific career and the impact he had on their lives and the scientific community.
Improvement of Rainwater Harvesting Analysis Through an Hourly Timestep Model in Comparison with a Daily Timestep Model
Authors: Alam Imteaz Monzur , Boulomytis Vassiliki 
Published: May 2022

AbstractFor the analysis of rainwater tank outcomes, some researchers used monthly water balance model, which ignores an important factor such as overflow from the tank. Recently, to improve the accuracy of such analysis facilitated by the availability of daily rainfall data, many researchers started using daily timestep models. In the daily timestep models, the daily rainwater demand is deducted from the available storage, once in a day and there are debates on whether to apply that deduction at the beginning of the day or at the end of the day. Moreover, there is significant diurnal variation of water demand, which can not be accounted for in a daily timestep model. To overcome this, current study investigates an hourly timestep model considering hourly rainfall data and hourly variable rainwater demands. Hourly rainfall data was collected from the Australian Bureau of Meteorology for a raingauge station located in Melbourne. An earlier developed daily water balance model was converted to hourly scale incorporating hourly variable rainwater demands. Model simulated results for three distinct years (dry, average and wet) were compared with the results using a daily timestep model with the same data. Variations of water savings and overflow amounts are presented under four combinations of roof area and daily rainwater demand with tank sizes varying from 2500 L to 20,000 L. It is found that in all the selected years, the daily timestep model underestimated the annual water savings compared to the hourly timestep model and the highest difference was estimated to be 13,750 L for a smaller tank size connected with a bigger roof having higher rainwater demand.
SysML modeling of service-oriented system-of-systems
Authors: Delsing Jerker , Kulcsár Géza , Haugen Øystein 
Published: May 2022

AbstractThe success of the ongoing fourth industrial revolution largely depends on our ways to cope with the novel design challenges arising from a combination of an enormous increase in process and product complexity, as well as the expected autonomy and self-organization of complex and diverse industrial hardware–software installments, often called systems-of-systems. In this paper, we employ the service-oriented architectural paradigm, as materialized in the Eclipse Arrowhead framework, to represent modern systems engineering principles and their open structural principles and, thus, relevance to flexible and adaptive systems. As for adequately capturing the structural aspect, we propose using model-based engineering techniques and, in particular, a SysML-based specialization of systems modeling. The approach is illustrated by a real-life use-case in industrial automation.
Basin-scale spatiotemporal distribution of ayu Plecoglossus altivelis and its relationship with water temperature from summer growth to autumn spawning periods
Authors: Nagayama Shigeya , Sueyoshi Masanao , Fujii Ryoji , Harada Morihiro 
Published: May 2022

AbstractAs climate warming progresses, it becomes necessary to study the effects of water temperature on the basin-scale dynamic distribution of riverine fish. This study examined the spatiotemporal distribution of Plecoglossus altivelis using the environmental DNA approach and its relationship with water temperature from summer growth to autumn spawning periods in the Nagara River basin, central Japan. The overall results of the spatiotemporal distribution of P. altivelis were consistent with the known life history: a wide-range distribution in the basin during summer and aggregation in the middle mainstem during autumn. Additionally, this study found three intriguing distribution patterns depending on water temperature. During summer (August), the warmest period, P. altivelis was distributed in the upper mainstem, one tributary, and the mainstem downstream of the tributary confluences in relation to the relatively colder water (< 25 °C). During early autumn (September–early October), it spread widely in the middle and upper mainstem without the constraint of the upper limit of water temperature. During late autumn (late October–November), it steadily aggregated to the middle mainstem because of downstream migration for spawning at water temperatures below 20 °C. This study suggests the importance of river connectivity for P. altivelis migration to suitable habitats during its freshwater life stages, upper mainstem and tributaries as summer growth habitats, and cooling effects of tributaries on the mainstem during mid-summer.
Agent models of customer journeys on retail high streets
Authors: Torrens Paul M. 
Published: May 2022

AbstractIn this review paper, we aim to make the case that a concept from retail analytics and marketing—the customer journey—can provide promising new frameworks and support for agent-based modeling, with a broad range of potential applications to high-resolution and high-fidelity simulation of dynamic phenomena on urban high streets. Although not the central focus of the review, we consider agent-based modeling of retail high streets against a backdrop of broader debate about downtown vitality and revitalization, amid a climate of economic challenges for brick-and-mortar retail. In particular, we consider how agent-based modeling, supported by insights from consideration of indoor shopping, can provide planning and decision support in outdoor high street settings. Our review considers abstractions of customers through conceptual modeling and customer typology, as well as abstractions of retailing as stationary and mobile. We examine high-level agency of shop choice and selection, as well as low-level agency centered on perception and cognition. Customer journeys are most often trips through geography; we therefore review path-planning, generation of foot traffic, wayfinding, steering, and locomotion. On busy high streets, journeys also manifest within crowd motifs; we thus review proximity, group dynamics, and sociality. Many customer journeys along retail high streets are dynamic, and customers will shift their journeys as they come into contact with experiences and service offerings. To address this, we specifically consider treatment of time and timing in agent-based models. We also examine sites for customer journeys, looking in particular at how agent-based models can provide support for the analysis of atmospherics, artifacts, and location-based services. Finally, we examine staff-side agency, considering store staff as potential agents outdoors; and we look at work to build agent-based models of fraud from customer journey analysis.
Zum Streit verurteilt?
Authors: Weber Sascha 
Published: May 2022

ZusammenfassungDer Beitrag versucht mit Hilfe einer organisationstheoretischen Perspektive auf Soziale Arbeit und Justiz die bislang wenig beachtete Auslöser für die notorischen Probleme bei der Zusammenarbeit zu identifizieren. Dabei werden historische, rechtsstaatliche, politische und funktionssystematische Voraussetzungen und Grenzen einer effektiveren Kooperation mit ihren jeweiligen Präventions- bzw. Repressionsformen aus dem Blick eines system- und differenzierungstheoretischen Bezugsrahmens mit Hilfe des Governance-Ansatzes analysiert.
Lehren und Studieren in der Zukunft
Authors: Domann Sophie , Oelker Birgit 
Published: May 2022

ZusammenfassungDer Beitrag veranschaulicht Ansätze einer informellen Lehrenden-Community aus den Bereichen Sozial- und Organisationspädagogik, die zu Beginn der Corona-Pandemie entstand, um mit adäquaten Szenarien der Studien- und Lehr‑/Lernorganisation seit 2020, also eines nunmehr weitgehend digitalisierten Studienangebots zu entsprechen.
Multiple myeloma with high-risk cytogenetics and its treatment approach
Authors: Hanamura Ichiro 
Published: May 2022

AbstractDespite substantial advances in anti-myeloma treatments, early recurrence and death remain an issue in certain subpopulations. Cytogenetic abnormalities (CAs) are the most widely accepted predictors for poor prognosis in multiple myeloma (MM), such as t(4;14), t(14;16), t(14;20), gain/amp(1q21), del(1p), and del(17p). Co-existing high-risk CAs (HRCAs) tend to be associated with an even worse prognosis. Achievement of sustained minimal residual disease (MRD)-negativity has recently emerged as a surrogate for longer survival, regardless of cytogenetic risk. Information from newer clinical trials suggests that extended intensified treatment can help achieve MRD-negativity in patients with HRCAs, which may lead to improved outcomes. Therapy should be considered to include a 3- or 4-drug induction regimen (PI/IMiD/Dex or PI/IMiD/Dex/anti-CD38 antibody), auto-transplantation, and consolidation/maintenance with lenalidomide ± a PI. Results from ongoing clinical trials for enriched high-risk populations will reveal the precise efficacy of the investigated regimens. Genetic abnormalities of MM cells are intrinsic critical factors determining tumor characteristics, which reflect the natural course and drug sensitivity of the disease. This paper reviews the clinicopathological features of genomic abnormalities related to adverse prognosis, focusing on HRCAs that are the most relevant in clinical practice, and outline current optimal therapeutic approaches for newly diagnosed MM with HRCAs.
Association Between VACS Index and Health-Related Quality of Life in Persons with HIV: Moderating Role of Fruit and Vegetable Consumption
Authors: Campbell Laura M. , Montoya Jessica L. , Fazeli Pariya L. , Marquine Maria J. , Ellis Ronald J. , Jeste Dilip V. , Moore David J. , Moore Raeanne C. 
Published: May 2022

Abstract
Background
The health status of people with HIV (PWH) influences their health-related quality of life (HRQOL). Modifiable lifestyle factors may improve HRQOL. This study (1) explores the association between modifiable lifestyle factors (physical activity and nutrition) and HRQOL and (2) examines if these lifestyle factors moderate the association health status and HRQOL.

Methods
Participants included 91 community dwelling PWH (age 36–65 years) from the university lab. Participants reported mental and physical HRQOL via the Medical Outcome Study 36-Item Short-Form (SF-36). Physical activity was examined via the International Physical Activity Questionnaire and nutrition (i.e., fruit and vegetable consumption) was assessed with the By-Meal Screener. Health status was ascertained via the Veterans Aging Cohort Study (VACS) Index.

Results
Aim 1 analyses indicated that neither physical activity nor nutrition was related to mental HRQOL (p’s > .05). However, greater physical activity (β = .33, p < .01) and nutrition (β = .23, p = .03) were each independently related to better physical HRQOL and remained significant after accounting for co-occurring medical conditions. For aim 2, the interaction between health status and nutrition was statistically significant (β = .24, p = .02), such that the association between worse health status and worse physical HRQOL was weaker with better nutrition. There was not a statistically significant interaction between physical activity and health status on physical HRQOL (p > .05).

Conclusion
Physical HRQOL is related to self-reported physical activity and nutrition, with nutrition showing a moderating effect on the association between health status and physical HRQOL. Thus, future interventional studies designed to improve physical HRQOL should target both physical activity and nutrition.
URS: een kostbare aangelegenheid?
Authors: Hendriks Nora , Duijvesz Diederick , Bosmans Judith E. , Maas Daniël C. , Zweers Joep , Pelger Rob C. M. , Beerlage Harrie P. , Kamphuis Guido M. , van den Brink Luna , Schout Barbara M. A. 
Published: May 2022

SamenvattingDe kosten van de gezondheidszorg stijgen. Bewustwording van daadwerkelijke kosten (in plaats van gemiddelde DBC-prijzen) is van groot belang om kosten te beteugelen. Hiertoe hebben wij voor 72 ureterorenoscopie (URS) procedures de gegevens over proceduretijd, materiaal, aanwezig personeel op OK, opname en follow-up prospectief geregistreerd. De totale kosten van een URS bedroegen gemiddeld € 2.819. De grootste kostenpost bestond uit chirurgische kosten (€ 2.075; 67,0%), gevolgd door opnamekosten (€ 514; 22,8%) en follow-upkosten (€ 230; 10,2%). Bij acht procedures bleek de steen gepasseerd ten tijde van de operatie en bleek de preoperatieve CT-scan ouder dan één maand. De kosten van deze procedures hadden voorkomen kunnen worden door een extra preoperatieve CT-scan te maken. Het verrichten van deze CT-scan zou een besparing kunnen opleveren van gemiddeld € 62 euro per procedure. De werkelijke kosten van een URS in dit cohort waren € 2.819, met als grootste kostenpost chirurgische kosten (€ 2.075). Het waarborgen van recente preoperatieve beeldvorming zou onnodige operaties en kosten kunnen besparen.