bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracheal Intubation in Emergency Departments in China: A National Cross-Sectional Survey
Authors: Dai Yili , Walline Joseph Harold , Yu Heng , Zhu Huadong , Xu Jun , Yu Xuezhong 
Published: February 2022

BackgroundTracheal intubation is a necessary but risky procedure performed in emergency departments (EDs) around the world. Relatively high morbidity has been encountered in Chinese EDs, which has raised concerns about peri-intubation ED management. This study aimed to investigate intubation procedures and identify any areas for improvement in Chinese EDs.MethodsThis was a questionnaire-based survey lasting 1 month (March 2021) in 41 tertiary-care hospital EDs in mainland China. The primary outcome was complications associated with intubation. Secondary outcomes were the first-pass success rate and blood pressure variations during intubation. Univariate and binary logistic regression analyses were used to find possible risk factors for first-pass intubation failure.ResultsIn total, 1,020 replies were analyzed out of 1,080 surveys submitted (94.4% response rate). Most patients were elderly men with severe medical conditions like cardiac arrest (24.8%). In total, 97.2% of patients were given preoxygenation, and 48.1% received some form of pretreatment. Induction drugs (e.g., etomidate and ketamine) were less often used: 39.9% of intubations used sedatives, 5.5% used analgesics, and only 5.3% used muscle relaxants. The overall first-pass intubation success rate was 85.7% and was accompanied by a 19.8% adverse event rate. A marked decrease in blood pressure after intubation was also identified.ConclusionThis survey found an 85.7% tracheal intubation first-pass success rate (which is relatively high compared to other countries) and a 19.8% adverse event rate (which is also relatively high). Given the very low rate of using induction medications (5.3% used muscle relaxants), future education should focus on induction drugs and traditional intubation techniques.
Soluble Interleukin-2 Receptor Predicts Treatment Outcome in Patients With Autoimmune Tubulointerstitial Nephritis. A Preliminary Study
Authors: Shiratori-Aso Satoka , Nakazawa Daigo , Nishio Saori , Ueda Yusho , Eguchi Mina , Yokoyama Ai , Yoshikawa Junpei , Kudo Takashi , Watanabe-Kusunoki Kanako , Takeda-Otera Sayo , Yamamoto Junya , Matsuoka Naoko , Kaneshima Nobuharu , Hattanda Fumihiko , Iwasaki Sari , Tsuji Takahiro , Fukasawa Yuichiro , Atsumi Tatsuya 
Published: February 2022

BackgroundAutoimmune tubulointerstitial nephritis (TIN) is characterized by immune-mediated tubular injury and requires immunosuppressive therapy. However, diagnosing TIN and assessing therapeutic response are challenging for clinicians due to the lack of useful biomarkers. Pathologically, CD4+T cells infiltrate to renal tubulointerstitium, and soluble interleukin-2 receptor (sIL-2R) has been widely known as a serological marker of activated T cell. Here, we explored the usefulness of serum sIL-2R to predict the treatment outcome in patients with autoimmune TIN.MethodsStudy Design: Single-center retrospective observational study.Participants62 patients were diagnosed of TIN from 2005 to April 2018 at Hokkaido University Hospital. Among them, 30 patients were diagnosed with autoimmune TIN and treated with corticosteroids. We analyzed the association between baseline characteristics including sIL-2R and the change of estimated glomerular filtration rate (eGFR) after initiation of corticosteroids.ResultsThe serum sIL-2R level in patients with autoimmune TIN was significantly higher than that in chronic kidney disease patients with other causes. Mean eGFR in autoimmune TIN patients treated with corticosteroids increased from 43.3 ± 20.4 mL/min/1.73 m2(baseline) to 50.7 ± 19.9 mL/min/1.73 m2(3 months) (ΔeGFR; 22.8 ± 26.0%). Multivariate analysis revealed that higher sIL-2R (per 100 U/mL, β = 1.102,P&lt; 0.001) level was independently associated with the renal recovery. In ROC analysis, sIL-2R had the best area under the curve value (0.805) and the cutoff point was 1182 U/mL (sensitivity = 0.90, 1-specificity = 0.45).ConclusionsOur study showed that elevated serum sIL-2R levels might become a potential predictive marker for therapeutic response in autoimmune TIN.
Cognitive Deficit and Aberrant Intrinsic Brain Functional Network in Early-Stage Drug-Naive Parkinson’s Disease
Authors: Zhang Lan , Yang Tao , Chen Yuping , Zheng Denise , Sun Dong , Tu Qiang , Huang Jinbai , Zhang Junjian , Li Zezhi 
Published: February 2022

BackgroundAlthough cognitive deficit is a common non-motor symptom of Parkinson’s disease (PD), the mechanism and valid biomarkers of it have not been identified. To our best knowledge, this was the first study to investigate the intrinsic dysconnectivity pattern of whole-brain functional networks in early-stage drug-naive (ESDN) PD patients and its association with cognitive deficit of PD using voxel-wise Degree Centrality (DC) approach.MethodsA total of 53 ESDN PD patients and 53 healthy controls (HC) were recruited. Resting-state fMRI (rs-fMRI) data were acquired, and voxel-wise DC approach was applied. Electrophysiological testing at P300 amplitude was recorded. The Montreal Cognitive Assessment (MoCA) was conducted to evaluate cognitive performance.ResultsESDN PD patients had lower MoCA scores and P300 amplitudes, but higher P300 latency, than HC (all p &lt; 0.0001). PD patients displayed higher DC in the right inferior frontal gyrus (IFG), left medial frontal gyrus (MFG) and left precentral gyrus (PreCG); but lower DC in the left inferior parietal lobule (IPL), left inferior temporal gyrus (ITG), right occipital lobe, and right postcentral gyrus (PoCG) (pBonferroni correction &lt; 0.0001). Interestingly, the DC values of left MFG, right PoCG and right occipital lobe were negatively associated with P300 latency but positively associated with P300 amplitudes and MoCA scores (all pBonferroni correction &lt; 0.0001).ConclusionsOur results indicate the cognitive deficit and abnormal intrinsic brain functional network in ESDN PD patients. The damage of Default Mode Network (DMN) may be contributes to the pathogenesis of cognitive dysfunction in ESDN PD.
Dopamine Transporter Imaging for Frontotemporal Lobar Degeneration With Motor Neuron Disease
Authors: Kobayashi Ryota , Kawakatsu Shinobu , Ohba Makoto , Morioka Daichi , Kanoto Masafumi , Otani Koichi 
Published: February 2022

IntroductionFrontotemporal lobar degeneration (FTLD) is a clinical syndrome with pathological heterogeneity, including Pick’s disease and trans-activating response region (TAR) DNA-binding protein with a molecular mass of 43 kDa (TDP-43) proteinopathy (FTLD-TDP). A previous study reported abnormal findings on dopamine transporter (DAT) imaging in 30% of patients with frontotemporal dementia (FTD) in FTLD. However, the previous study did not consider the pathological heterogeneity of FTD regarding the pathomechanism leading to abnormal DAT findings. Recently, abnormal DAT findings were reported in two patients with FTLD with motor neuron disease (MND), of which FTLD-TDP type B was the most common pathological presentation. This study investigated the DAT findings of patients with a final diagnosis of FTLD-MND to determine the frequency of occurrence of DAT abnormalities in FTLD-MND.MethodsTwenty patients with FTLD who underwent DAT single photon emission computed tomography (DAT-SPECT) were screened, and six patients with a final diagnosis of FTLD-MND were ultimately included. The patients’ DAT-SPECT findings were analyzed visually and quantitatively. Neuronal loss and astrogliosis in brain regions (substantia nigra, caudate, and putamen) that could possibly affect DAT findings were evaluated in the three pathologically confirmed cases.ResultAll six patients with FTLD-MND showed abnormal visual DAT-SPECT findings. In addition, in a quantitative assessment, the specific binding ratio in the striatum calculated by the Southampton method was below the lower limit of the 95% prediction interval of the healthy controls by age in all the present cases. Interestingly, three of the six patients showed abnormal findings on DAT-SPECT more than half a year before the onset of MND. Neuronal loss and astrogliosis in brain regions that may affect DAT findings were observed in three pathologically confirmed cases.ConclusionDopamine transporter single photon emission computed tomography revealed abnormal findings in patients with FTLD-MND, which may manifest even before the onset of MND symptoms. We believe that the possibility of future development of MND should be considered if DAT-SPECT shows abnormal findings in FTLD.
A Predictive Nomogram for Early Death in Pheochromocytoma and Paraganglioma
Authors: Li Huiyang , Abbas Kirellos Said , Abdelazeem Basel , Xu Yao , Lin Yile , Wu Haixiao , Chekhonin Vladimir P. , Peltzer Karl , Zhang Chao 
Published: February 2022

BackgroundPheochromocytoma (PHEO) and paraganglioma (PGL) are relatively rare neuroendocrine tumors. The factors affecting patients with early death remain poorly defined. We aimed to study the demographic and clinicopathologic pattern and to develop and validate a prediction model for PHEO/PGL patients with early death.MethodsData of 800 participants were collected from the Surveillance Epidemiology and End Results (SEER) database as a construction cohort, while data of 340 participants were selected as a validation cohort. Risk factors considered included the year of diagnosis, age at diagnosis, gender, marital status, race, insurance status, tumor type, primary location, laterality, the presence of distant metastasis. Univariate and multivariate logistic regressions were performed to determine the risk factors. R software was used to generate the nomogram. Calibration ability, discrimination ability, and decision curve analysis were analyzed in both construction and validation cohorts.ResultsPHEO and PGL patients accounted for 54.3% (N=434) and 45.7% (N=366), respectively. More than half of tumors (N=401, 50.1%) occurred in the adrenal gland, while 16.9% (N=135) were in aortic/carotid bodies. For the entire cohort, the median overall survival (OS) was 116.0 (95% CI: 101.5-130.5) months. The multivariate analysis revealed that older age (versus age younger than 31; age between 31 and 60: OR=2.03, 95% CI: 1.03-4.03, P=0.042; age older than 60: OR=5.46, 95% CI: 2.68-11.12, P&lt;0.001), female gender (versus male gender; OR=0.59, 95% CI: 0.41-0.87, P=0.007), tumor located in aortic/carotid bodies (versus tumor located in adrenal gland; OR=0.49, 95% CI: 0.27-0.87, P=0.015) and the presence of distant metastasis (versus without distant metastasis; OR=4.80, 95% CI: 3.18-7.23, P&lt;0.001) were independent risk factors of early death. The predictive nomogram included variables: age at diagnosis, gender, primary tumor location, and distant metastasis. The model had satisfactory discrimination and calibration performance: Harrell’s C statistics of the prediction model were 0.733 in the construction cohort and 0.716 in the validation cohort. The calibration analysis showed acceptable coherence between predicted probabilities and observed probabilities.ConclusionsWe developed and validated a predictive nomogram utilizing data from the SEER database with satisfactory discrimination and calibration capability which can be used for early death prediction for PHEO/PGL patients.
Tuberculosis Prevalence and Predictors Among Health Care-Seeking People Screened for Cough of Any Duration in Ethiopia: A Multicenter Cross-Sectional Study
Authors: Mohammed Hussen , Oljira Lemessa , Roba Kedir Teji , Ngadaya Esther , Manyazewal Tsegahun , Ajeme Tigest , Mnyambwa Nicholaus P. , Fekadu Abebaw , Yimer Getnet 
Published: February 2022

BackgroundTuberculosis (TB) remains a major cause of morbidity and mortality in sub-Saharan Africa. This high burden is mainly attributed to low case detection and delayed diagnosis. We aimed to determine the prevalence and predictors of TB among health care-seeking people screened for cough of any duration in Ethiopia.MethodsIn this multicenter cross-sectional study, we screened 195,713 (81.2%) for cough of any duration. We recruited a sample of 1,853 presumptive TB (PTB) cases and assigned them into three groups: group I with cough ≥2 weeks, group II with cough of &lt;2 weeks, and group III pregnant women, patients on antiretroviral therapy, and patients with diabetes. The first two groups underwent chest radiograph (CXR) followed by sputum Xpert MTB/RIF assay or smear microscopy. The third group was exempted from CXR but underwent sputum Xpert MTB/RIF assay or smear microscopy. TB prevalence was calculated across the groups and TB predictors were analyzed using modified Poisson regression to compute adjusted prevalence ratio (aPR) with a 95% confidence interval (CI).ResultsThe overall prevalence of PTB was 16.7% (309/1853). Of the positive cases, 81.2% (251/309) were in group I (cough ≥2 weeks), 14.2% (44/309) in group II (cough of &lt;2), and 4.5% (14/309) in group III (CXR exempted). PTB predictors were age group of 25–34 [aPR = 2.0 (95% CI 1.3–2.8)], history of weight loss [aPR = 1.2 (95% CI 1.1–1.3)], and TB suggestive CXRs [aPR = 41.1 (95% CI 23.2–72.8)].ConclusionThe prevalence of confirmed PTB among routine outpatients was high, and this included those with a low duration of cough who can serve as a source of infection. Screening all patients at outpatient departments who passively report any cough irrespective of duration is important to increase TB case finding and reduce TB transmission and mortality.
Research on Health and Thermal Comfort of Unit-Type Student Apartments in the Western China Science and Technology Innovation Harbor
Authors: Wang Zanshe , Wu Yue , Jia Zhaoying , Gao Qi , Gu Zhaolin 
Published: February 2022

BackgroundIn China, the collective living mode of “multiple people living in one room” is widely used in college students' dormitories; the space environment has high personnel density and poor thermal comfort and healthy environment. The unit-type apartments were completed in the western China science and technology innovation harbor that considers personal independence and public activity spaces.AimThe purpose of this study is to explore the applicability, thermal comfort, healthy environment, and the correlation of influencing variables of the new unit-type apartment. Especially the influence of physical parameters on personal space under heating in winter and air conditioning in summer.MethodThe field investigations and questionnaires to conduct a personal study of architectural space, healthy environment, and thermal comfort were carried out, and the measurement tests of the building's physical environment were carried out in winter and summer semesters.ResultsThe questionnaires survey shows that the privacy of the unit apartment is satisfactory, and the independent learning and communication is increased. The field measurement results show that due to the narrow space of the private room, the floor radiant heating mode still forms a hot and dry thermal environment in winter, and the temperature fluctuates significantly after the air conditioner is turned on in summer.ConclusionsThe unit-type apartments align with young students' physiological and psychological characteristics and the behavioral aspects of postgraduates, with high comprehensive satisfaction up to 80%. However, the indoor thermal environment quickly fluctuates due to the narrow independent space. Moreover, 90% of the window ventilation ratio shows that it has become the main measure to actively regulate the indoor climate, which is beneficial to students' health but increases energy waste and further aggravates the fluctuation of the thermal environment. More refined regulations should be executed for heating in winter and air conditioning in summer.
Clinical and Functional Outcomes of Patients Receiving Cerebral Reperfusion Therapy: A Stroke Databank Study in Brazil
Authors: Furlan Natalia Eduarda , Luvizutto Gustavo José , Hamamoto Filho Pedro Tadao , Zanati Bazan Silmeia Garcia , Modolo Gabriel Pinheiro , Ferreira Natalia Cristina , Miranda Luana Aparecida , de Souza Juli Thomaz , Winckler Fernanda Cristina , Vidal Edison Iglesias de Oliveira , de Freitas Carlos Clayton Macedo , Martin Luis Cuadrado , Bazan Rodrigo 
Published: February 2022

ObjectivesCerebral reperfusion therapy is recommended for the treatment of acute ischemic stroke. However, the outcomes of patients receiving this therapy in middle- and low-income countries should be better defined. This study aimed to evaluate the clinical and functional outcomes of cerebral reperfusion therapy in patients with ischemic stroke.Materials and MethodsThis retrospective study included patients with ischemic stroke treated with cerebral reperfusion therapy, including intravenous thrombolysis (IVT), mechanical thrombectomy (MT), and IVT with MT. The primary outcomes were death and disability, assessed using the modified Rankin scale (mRS), and stroke severity, assessed using the National Institutes of Health Stroke Scale (NIHSS), after intervention and 90 days after ictus. The association between the type of treatment and the primary outcome was assessed using binary logistic regression after adjusting for confounding variables. Furthermore, receiver operating characteristic (ROC) curves were generated to identify the cutoff point of the NIHSS score that could best discriminate the mRS score in all types of treatments.ResultsPatients (n = 291) underwent IVT only (n = 241), MT (n = 21), or IVT with MT (n = 29). In the IVT with MT group, the incidence of death within 90 days increased by five times (OR, 5.192; 95% CI, 2.069–13.027; p = 0.000), prevalence of disability increased by three times (OR, 3.530; 95% CI, 1.376–9.055; p = 0.009) and NIHSS score increased after IVT (from 14.4 ± 6.85 to 17.8 ± 6.36; p = 0.045). There was no significant difference between the initial NIHSS score and that after MT (p = 0.989). Patients' NIHSS score that increased or decreased by 2.5 points had a sensitivity of 0.74 and specificity of 0.65, indicating severe disability or death in these patients.ConclusionAltogether, a 2.5-point variation in NIHSS score after reperfusion is an indicator of worse outcomes. In our particular context, patients receiving the combination of IVT and MT had inferior results, which probably reflects challenges to optimize MT in LMIC.
External Validation and Comparison of Two Nomograms Predicting the Probability of Lymph Node Involvement in Patients subjected to Robot-Assisted Radical Prostatectomy and Concomitant Lymph Node Dissection: A Single Tertiary Center Experience in the MRI-Era
Authors: Frego Nicola , Paciotti Marco , Buffi Nicolò Maria , Maffei Davide , Contieri Roberto , Avolio Pier Paolo , Fasulo Vittorio , Uleri Alessandro , Lazzeri Massimo , Hurle Rodolfo , Saita Alberto , Guazzoni Giorgio Ferruccio , Casale Paolo , Lughezzani Giovanni 
Published: February 2022

IntroductionTo externally validate and directly compare the performance of the Briganti 2012 and Briganti 2019 nomograms as predictors of lymph node invasion (LNI) in a cohort of patients treated with robot-assisted radical prostatectomy (RARP) and extended pelvic lymph node dissection (ePLND).Materials and MethodsAfter the exclusion of patients with incomplete biopsy, imaging, or clinical data, 752 patients who underwent RARP and ePLND between December 2014 to August 2021 at our center, were included. Among these patients, 327 (43.5%) had undergone multi-parametric MRI (mpMRI) and mpMRI-targeted biopsy. The preoperative risk of LNI was calculated for all patients using the Briganti 2012 nomogram, while the Briganti 2019 nomogram was used only in patients who had performed mpMRI with the combination of targeted and systematic biopsy. The performances of Briganti 2012 and 2019 models were evaluated using the area under the receiver-operating characteristics curve analysis, calibrations plot, and decision curve analysis.ResultsA median of 13 (IQR 9–18) nodes per patient was removed, and 78 (10.4%) patients had LNI at final pathology. The area under the curves (AUCs) for Briganti 2012 and 2019 were 0.84 and 0.82, respectively. The calibration plots showed a good correlation between the predicted probabilities and the observed proportion of LNI for both models, with a slight tendency to underestimation. The decision curve analysis (DCA) of the two models was similar, with a slightly higher net benefit for Briganti 2012 nomogram. In patients receiving both systematic- and targeted-biopsy, the Briganti 2012 accuracy was 0.85, and no significant difference was found between the AUCs of 2012 and 2019 nomograms (p = 0.296). In the sub-cohort of 518 (68.9%) intermediate-risk PCa patients, the Briganti 2012 nomogram outperforms the 2019 model in terms of accuracy (0.82 vs. 0.77), calibration curve, and net benefit at DCA.ConclusionThe direct comparison of the two nomograms showed that the most updated nomogram, which included MRI and MRI-targeted biopsy data, was not significantly more accurate than the 2012 model in the prediction of LNI, suggesting a negligible role of mpMRI in the current population.
Arumugam Novel in Anthropology Perspectives
Authors: K Suresh Kumar 
Published: February 2022

The disciplines of Anthropology which study the human ethnicities is systematically and scientifically register the intricacies of various ethnic groups. In this article, the novel Arumugam by Imayam is seen through the parameters of literal anthropology. The primary objective of this article is that if we approach the novels and short stories which depict about the downtrodden through anthropological perspectives, it is possible that these communities can improve considerably in every respect. In order to establish this hypothesis this article is being built on the assumption that literature in general is concerned about the human societies. Through this article it is proved with evidence that if we can approach novel literature on the perspectives of the discipline literal anthropology, it is possible to understand more scientifically and clearly various ethnic groups and establish their ethnic specific behavior. Further, this article could infer that the main cause for the sufferings of the downtrodden communities is their economic backwardness. Apart from this, the article could identify and explain vividly that the down trodden communities though they have attained sophistication in culture and habits, still their status is below the general standard and the other communities are treating them and approaching them with a different yard stick.
Las instituciones y las organizaciones educativas como objeto de análisis y producción de conocimiento situado. Notas para pensar la formación
Authors: Nicastro Sandra 
Published: February 2022

En este trabajo nos interesa reflexionar acerca de nuestro lugar como formadorxs que, atravesadxs y conmovidxs ante los escenarios actuales, reflexionamos acerca del abordaje de las instituciones y las organizaciones educativas como objetos de análisis y producción de conocimiento situado. Para ello proponemos un trabajo de elucidación permanente sobre nuestra posición implicada, como una oportunidad para pensar a otrxs y con otrxs, los efectos de dispersión que esos contextos portan y tienen sobre los procesos de subjetivación y de pensamiento colectivos, y entendiendo que se trata de un lugar que se construye en determinados tiempos y espacios institucionales, sociales, históricos, políticos.
Nuestra reflexión se apoya en los trabajos de algunxs representantes del análisis institucional francés, latinoamericano y argentino que reconocieron que al pensar la posición que asumimos frente al análisis es importante tener en cuenta una serie de cuestiones relativas a la relación de las instituciones, las organizaciones, los grupos y los sujetos desde perspectivas situadas y contextualizadas.