bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinicopathological features of programmed death ligand-1 expression in colorectal carcinoma
Authors: Al-Jussani Ghada N. , Alsughayer Anas , Yousuf Mustafa S. , Mullahuwash Yaseen , Dabbagh Tamara , Sughayer Maher A. 
Published: May 2022

Background Few studies have addressed the clinicopathological features of colorectal cancer (CRC) that express programed death-ligand 1 (PD-L1). Various assays and scoring methodologies were used and thus inconsistent results were obtained. In this study, we aimed to investigate the relationship of PD-L1 expression in CRC with various clinicopathological variables using a standardized assay and scoring algorithm. Design Tissue microarrays were constructed from 91 random cases of CRC diagnosed at King Hussein Cancer Center (KHCC). Immunohistochemical (IHC) staining using the monoclonal antibody 22C3 was performed. Scoring using the standard “Combined Positive Score” (CPS) method was done. CPS of ≥1 was considered positive. Various clinicopathological features were collected from the medical records of the patients. Results Of the 91 cases, 49 (53.8%) were PD-L1 positive (CPS ≥1). PD-L1 expression was more frequent among moderately differentiated carcinomas (43 of 72 (59.7%) were positive compared to 6 of 19 (31.5%) poorly differentiated cases ( P = 0.029)); among node negative cases (21 of 24 (87.5%) N0 cases were PD-L1 positive in contrast to 28 of 67 (41.8%) N1/N2 cases ( P = <0.001)); among mucinous subtype (12 of 15 (80%) of cases ( P = 0.02)); and among mismatch repair deficient (dMMR) (16 of 16 (100%) versus 11 of 30 (36.6%) MMR proficient ( P = <0.001)). Age, gender, localization, and T or M stages were not significantly associated with PD-L1 expression. Conclusion PD-L1 expression in CRC is associated with favorable prognostic features; namely, lower grade, N0, mucinous variant, and dMMR tumors.
Proton pump inhibitor induced subacute cutaneous lupus erythematosus: Clinical characteristics and outcomes
Authors: Poh Yih Jia , Alrashid Abdulrahman , Sangle Shirish R , Higgins Eleanor , Benton Emma , McGibbon David , D’Cruz David P 
Published: May 2022

Background There is a growing literature reporting the association between proton pump inhibitor (PPI) use and subacute cutaneous lupus erythematosus (SCLE). Aims To compare the clinical characteristics of a cohort of patients with PPI-induced SCLE, their clinical course and treatment with a control group of primary SCLE patients not exposed to PPI. Methods We conducted a matched case–control study in a tertiary referral setting at the Louise Coote Lupus Unit. There were 64 SCLE patients: 36 with PPI-induced SCLE and 28 patients with primary SCLE. Results Twenty-six patients (72%) had pre-existing SLE in the PPI-induced SCLE group. Lower limb skin lesions were significantly more prevalent in the PPI group ( p < 0.0001). The prevalence of anti-Ro and anti-Ro-52 antibodies was numerically higher in the PPI group (64% and 60%), respectively, compared with 46% and 42% in the primary SCLE group. Peripheral blood eosinophils were normal in all patients in the PPI group. Thirteen patients underwent skin biopsy in the PPI group and 12 had histology in keeping with SCLE. The median time to presentation was 8 months with a median resolution period of 6 weeks. PPIs were stopped in 34 patients, while 2 patients continued treatment for other clinical indications. Twelve patients received concurrent oral corticosteroids. Two patients had severe SCLE in the form of Toxic Epidermal Necrolysis requiring critical care admission and were managed with corticosteroids, IV immunoglobulin and/or belimumab. Conclusion Lower limb involvement is a pointer to PPI-induced SCLE which is likely a class effect with all PPI.
Medicare-subsidised mental health services from the beginning of Better Access in 2006–2007 to 2019–2020: Descriptive analysis by state, profession and consultation profile
Authors: Looi Jeffrey C.L. , Maguire Paul A. , Allison Stephen , Bastiampillai Tarun 
Published: May 2022

Objective Since 2006, the Australian Federal Government has aimed at expanding mental healthcare through the ‘Better Access’ programme of Medicare-subsidised services by private practitioners. We comment on population access to subsidised mental health treatment via health professionals in Australia. Methods We descriptively analysed Australian Institute of Health and Welfare (AIHW) data. Results Increasing percentages of the Australian population of people received Medicare-subsidised services from 2008–09 to 2019–20. Population access to mental health treatment increased from 5.7% to 10.7%. In 2019–20, psychiatrists provided services for 1.7% of the population, while GPs provided for 8.8%, clinical psychologists 2.2%, registered psychologists 2.9%, and other allied health providers 0.4%. Over the period, numbers of Australian psychiatrists providing services increased, but the numbers of patients seen per year, and other indicators, have either been flat or declined. GP, Psychologist, Clinical Psychologist and other allied health consultations increased overall, but again the numbers of sessions have decreased. Conclusions Medicare-subsidised private practice has greatly increased population access to mental health treatment. However, there appear to be a relatively limited number of consultations per patient for most provider groups. Further research is required on the effectiveness of treatment through collecting data on casemix and outcomes.
Operating room waste management: A case study of primary hip operations at a leading National Health Service hospital in the United Kingdom
Authors: Pegg Melissa , Rawson Rebecca , Okere Uchechukwu 
Published: May 2022

Objective This research examines current waste management within an operating room at a large United Kingdom National Health Service (NHS) hospital. The study measured the volume and type of waste produced for primary hip operations (PHOs) and estimated the total waste produced across the United Kingdom by the procedure. Methods Three PHOs were audited to measure and compare the waste volumes generated. Results The average volume of waste per surgical procedure was 10.9 kg, consisting of clinical (84.4%), recyclable (12.8%) and bio-bin (2.8%) waste. This research also found that single-use devices contribute significantly to operating room waste. In addition, it was estimated that there is a missed opportunity to reduce clinical waste volume in each procedure, where approximately 15% of clinical waste disposal consisted of visibly clean recyclable waste material, including cardboard and plastics. Conclusions It was estimated that in the NHS approximately 1043 tonnes of waste is produced annually by PHOs alone. A significant volume of this waste could be prevented through improved recycling and reduced use of single-use devices.
Use of azurocidin (heparin binding protein) and interleukin-1ß as prognostic indicators in COVID-19 patients
Authors: Akın Şen İrem , Karaşahin Ömer , Şebin Engin , Şen Cem 
Published: May 2022

Objective: Considering the published manuscripts on this subject, it is thought that IL-1B and azurocidin may be diagnostic and prognostic factors in severe COVID-19 disease. This study aimed to determine whether azurocidin and IL-1β are useful biomarkers and are associated with disease exacerbation in patients needing advanced treatment options. Material and Method: Our study was performed retrospectively. The data of a total of 291 patients followed in the hospital due to COVID-19 were collected. Among these patients, 66 randomly selected patients were included in this study. The control group consisted of 24 healthy individuals referred to the infectious disease outpatient clinic who weren’t no diagnosis of COVID-19 infection or any other infection. After the samples were taken into tubes without anticoagulant, they were kept at room temperature for 30 min. Afterwards, it was centrifuged at 1000xg for 15 min at +4° according to the instructions of the ELISA kit we used. The remaining serum was transferred to Eppendorf tubes and stored at −80° throughout this study. Results: A statistically significant strong positive correlation was determined between IL1β and azurocidin. A statistically significant weak positive correlation was found between IL1β and CRP, ferritin and neutrophil count, weak negative correlation with albumin, and moderately strong positive correlation with leukocyte count. Moreover, a statistically significant weak positive correlation was found between azurucidin and CRP, ferritin, and neutrophil counts. Conclusion: Azurocidin and IL-1β may serve as a potential therapeutic target for patients at risk of developing systemic multi-organ failure, with improved patient prognosis and prevention of death in severely ill patients. Although these results may contribute to the improvement of the follow-up and treatment of the patients and reduce mortality rates, there is a need for randomized controlled studies with a larger number of patients to be performed in the future.
Beyond dyadic communication: Network of communication in inflammatory arthritis teams
Authors: Ghanouni Parisa , Inouye Kristy , Gowan Chelsey , Hartford Wendy , McKinnon Annette , McQuitty Shanon , Backman Catherine L. , Li Linda C. , Nimmon Laura 
Published: May 2022

Following diagnosis, individuals with chronic conditions such as inflammatory arthritis (IA) face learning how to manage multiple new healthcare relationships. Despite existing literature on team care for people with IA, little is known about how teams negotiate care from perspectives of all team members. Objective To explore how communication is perceived and care is negotiated amongst IA healthcare teams by drawing on the perspectives of each team member. Method This analysis drew on data from an ongoing three-year study exploring team-based IA care. We interviewed 11 participants including two men with IA and their family care providers and healthcare providers. We used a three-staged analytic process and integrated broad tenets of social network theory to understand the relational dimensions of team members experiences. Result Analysis revealed three themes regarding communication and care: (1) seeking/sharing information, (2) striving to coordinate unified care, and (3) providing patients a voice. Discussion This study emphasizes the importance of understanding team dynamics beyond the dyad of patient and care provider. Negotiating power and decision-making in IA care is a dynamic process involving shifting levels of responsibility amongst a care team. Communication-based strategies that extend dyadic interactions may enhance teamwork and health outcomes in chronic conditions.
Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States
Authors: Titcomb Tyler J. , Bao Wei , Du Yang , Liu Buyun , Snetselaar Linda G. , Wahls Terry L. 
Published: May 2022

Background Multiple sclerosis (MS) has been associated with increased mortality ratios, but few studies have investigated the independent association of MS with mortality. Objective To examine the prospective association of MS with risk of mortality in a nationally representative sample of U.S. adults. Methods This prospective study included 23,053 adults aged 45–79 years who participated in the National Health Interview Survey in 2002 and 2008. Physician-diagnosed MS was reported by participants during household interviews. These participants were linked to death records from survey date through December 31, 2015. Results Among the 23,053 participants included in this study, 120 reported a physician’s diagnosis of MS, with a higher prevalence in females (0.85%) than in males (0.31%). During on average 9.4 years (maximum 13.8 years) of observation, 4208 deaths occurred. After adjustment for age, sex, race/ethnicity, socioeconomic factors, lifestyle factors, and BMI, participants with MS had an 80% higher risk of mortality (HR 1.80; 95% CI, 1.11–2.92), compared with those without MS. The association remained significant (HR 1.75; 95% CI, 1.07–2.87) after further adjustment for baseline diabetes, cardiovascular disease, chronic lung disease, and cancer. Conclusion In this nationally representative sample of U.S. adults, MS was associated with an increased risk of mortality.
Sustainable Care: Care as a Communal Virtue in Early Childhood Education
Authors: Eidsvåg Gunnar Magnus 
Published: May 2022

Purpose Care is a core concern for early childhood education and care (ECEC) institutions. Care may be understood as a basic form of interaction and a foundational need for human beings. For these reasons, care also presents challenges for ECEC staff. The staff must seek practical solutions to problems that philosophers have raised on a theoretical basis concerning ethical traditions, such as the ethics of care. These are the problems of justice, parochialism, and self-sacrifice. Design/Approach/Methods This article develops a theory concerning the ethics of care in ECEC institutions. The theory is informed by qualitative interviews with ECEC teachers reflecting on their caring practices. The study is therefore located at the intersection of normative ethics and applied ethics. In seven in-depth interviews, the informants discussed how to create a caring ECEC environment that is fair and possible to maintain over time. Findings Through analyzing the interviews, I found that caring practices that work toward these ideals can be described as sustainable care. These practices take care of all the children and provide the staff with opportunities to regain the strength they need to create a caring and educating setting. Originality/Value The theory this article develops makes ethics of care applicable and practically relevant to ECEC institutions.
Evaluation of the relationship between miR-337-3p and RAP1A gene in endometriosis
Authors: Dehghanian Mehran , Yarahmadi Ghafour , Fazeli Javad , Vahidi Mehrjardi Mohammad Yahya , Javaheri Atiyeh , Kalantar Seyed Mehdi , Dehghani Mohammadreza 
Published: May 2022

Background: Endometriosis, a prevalent multifactorial condition, has a different effect on mental and physical health in women. MicroRNAs have been reported as a main epigenetic factor in endometriosis pathogenesis. However, the role of miR-337-3p and its direct target gene, RAP1A, in endometriosis tissues have not been investigated. Objective: The aim of this study was to evaluate the expression level of miR-337-3p and RAP1A gene in endometriosis tissues and normal endometrium tissues. Materials and methods: We measured the expression levels of miR-337-3p and RAP1A gene by quantitative polymerase chain reaction (qRT-PCR) in 15 eutopic and ectopic tissue samples of superficial peritoneal lesions from women with endometriosis and 15 normal endometrial tissue samples from women without any symptom of endometriosis. Results: The results showed the expression level of RAP1A gene significantly increased in endometriosis tissue samples (both of ectopic and eutopic tissues), while miR-337-3p expression level decreased significantly in these tissues compared to the normal endometrium. Conclusion: In this study, we observed an inverse relationship between miR-337-3p and RAP1A gene expression in endometriosis. Dysregulation of these genes can also be interpreted as their role in the pathogenesis and progression of endometriosis.
Evaluation of Voice After Open Airway Surgery in Children: A Systematic Review
Authors: Arantes Mariah de Souza , Almeida Amanda Sampaio , Constantini Ana Carolina , Prata Luciahelena , Pazinatto Debora Bressan , Oliveira Ana Paula de Morais e , Maunsell Rebecca 
Published: May 2022

ObjectiveThis review aims to describe the methods used to assess the vocal quality and quality of life of children after airway reconstruction and their limitations.Data SourcesA systematic review was carried out in 10 databases for articles published between 2000 and 2021 following the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta‐analyses).Review MethodsArticles were included that described perceptual voice assessment with or without acoustic measures and/or voice quality impact questionnaires. Articles with no description of a specific voice assessment were excluded.ResultsA total of 12 studies were included, yielding 263 patients. The mean age at evaluation was 9 years. Follow‐up varied from 5 months to 20 years with most patients being evaluated at least a year after surgery. Methods used to evaluate voice were perceptual, aerodynamic, and acoustic analysis and quality of life questionnaires. CAPE‐V (Consensus Auditory Perceptual Evaluation–Voice) was the most used auditory‐perceptual instrument (72.7%). Of the acoustic parameters, fundamental frequency and maximum phonation time were the most described (58.3%), and among the quality of life assessment questionnaires, pVHI (Pediatric Voice Handicap Index) was the most used (54.5%).ConclusionMultidimensional evaluations tailored to the individual child can be recommended after open airway surgery. CAPE‐V scale, fundamental frequency, maximum phonation time, and pVHI are the most frequently used methods; therefore, their use may help broaden communication among authors. In the multitude of methods available, cognitive ability and degree of voice disturbance should be considered since they are the most important limiting factors in this population.
Internal Defects Detection Method of the Railway Track Based on Generalization Features Cluster Under Ultrasonic Images
Authors: Wu Fupei , Xie Xiaoyang , Guo Jiahua , Li Qinghua 
Published: May 2022

AbstractThere may be several internal defects in railway track work that have different shapes and distribution rules, and these defects affect the safety of high-speed trains. Establishing reliable detection models and methods for these internal defects remains a challenging task. To address this challenge, in this study, an intelligent detection method based on a generalization feature cluster is proposed for internal defects of railway tracks. First, the defects are classified and counted according to their shape and location features. Then, generalized features of the internal defects are extracted and formulated based on the maximum difference between different types of defects and the maximum tolerance among same defects’ types. Finally, the extracted generalized features are expressed by function constraints, and formulated as generalization feature clusters to classify and identify internal defects in the railway track. Furthermore, to improve the detection reliability and speed, a reduced-dimension method of the generalization feature clusters is presented in this paper. Based on this reduced-dimension feature and strongly constrained generalized features, the K-means clustering algorithm is developed for defect clustering, and good clustering results are achieved. Regarding the defects in the rail head region, the clustering accuracy is over 95%, and the Davies-Bouldin index (DBI) index is negligible, which indicates the validation of the proposed generalization features with strong constraints. Experimental results prove that the accuracy of the proposed method based on generalization feature clusters is up to 97.55%, and the average detection time is 0.12 s/frame, which indicates that it performs well in adaptability, high accuracy, and detection speed under complex working environments. The proposed algorithm can effectively detect internal defects in railway tracks using an established generalization feature cluster model.
The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review
Authors: Tavalaee Marziyeh , Rahmani Mohsen , Drevet Joël R. , Nasr-Esfahani Mohammad Hossein 
Published: May 2022

AbstractBackgroundInfertility related to varicocele, infections, metabolic dysfunctions, oxidative stress and environmental toxicants is also associated with inflammatory processes that ultimately lead to the activation of the inflammasome pathway (IP). IP is classically activated by DAMPs, MAMPs or LAMPs, which stand for Damage-, Microbe- or Lifestyle-Associated Molecular Patterns, respectively. The most important player in IP activation is the NLRP3 (NOD[Nuclear oligomerization domain]-, LRR[Leucine rich repeat]- and pyrin domain-containing protein 3) which functions as an intracellular sensor of D/M/L-AMPs resulting in activation of caspase-1, promotion of apoptosis, pyroptosis and generation of inflammatory cytokines. This review addresses the question of whether IP activation might be associated with male infertility situations.Results & conclusionsWe conducted a systematic review of articles published in the Google Scholar, and PubMed databases through October 2021. It turns out that inflammasome activation and its consequences including cytokine storms, apoptosis and pyroptosis could be associated with the reduced sperm count as well as the structural and functional sperm defects recorded in several situations associated with male infertility suggesting that anti-inflammatory therapeutic strategies could be possibly considered to restore male fertility in future research.
Overlapping group screening for detection of gene-environment interactions with application to TCGA high-dimensional survival genomic data
Authors: Wang Jie-Huei , Wang Kang-Hsin , Chen Yi-Hau 
Published: May 2022

Abstract
Background
In the context of biomedical and epidemiological research, gene-environment (G-E) interaction is of great significance to the etiology and progression of many complex diseases. In high-dimensional genetic data, two general models, marginal and joint models, are proposed to identify important interaction factors. Most existing approaches for identifying G-E interactions are limited owing to the lack of robustness to outliers/contamination in response and predictor data. In particular, right-censored survival outcomes make the associated feature screening even challenging. In this article, we utilize the overlapping group screening (OGS) approach to select important G-E interactions related to clinical survival outcomes by incorporating the gene pathway information under a joint modeling framework.

Results
Simulation studies under various scenarios are carried out to compare the performances of our proposed method with some commonly used methods. In the real data applications, we use our proposed method to identify G-E interactions related to the clinical survival outcomes of patients with head and neck squamous cell carcinoma, and esophageal carcinoma in The Cancer Genome Atlas clinical survival genetic data, and further establish corresponding survival prediction models. Both simulation and real data studies show that our method performs well and outperforms existing methods in the G-E interaction selection, effect estimation, and survival prediction accuracy.

Conclusions
The OGS approach is useful for selecting important environmental factors, genes and G-E interactions in the ultra-high dimensional feature space. The prediction ability of OGS with the Lasso penalty is better than existing methods. The same idea of the OGS approach can apply to other outcome models, such as the proportional odds survival time model, the logistic regression model for binary outcomes, and the multinomial logistic regression model for multi-class outcomes.