bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: Association of metabolic syndrome with TyG index and TyG-related parameters in an urban Chinese population: a 15-year prospective study
Authors: Zhang Xin , Zhang Ting , He Sen , Jia Shanshan , Zhang Zhipeng , Ye Runyu , Yang Xiangyu , Chen Xiaoping 
Published: June 2022

Abstract
Background
The metabolic syndrome (Mets) is a multiplex risk factor for atherosclerotic cardiovascular diseases. The aims of the study were to assess the association of the Mets with TyG index and TyG-related parameters in an urban Chinese population.

Methods
The data were collected in 1992 and then again in 2007 from the same group of 590 individuals (363 males and 227 females) without Mets in 1992. The fasting lipid profile and blood glucose were measured. TyG index and related parameters were calculated, and Mets defined according to the harmonized criteria. The area under the curve (AUC) of receiver operating characteristic curves was used to evaluate TyG index and related parameters for their diagnostic ability to identify people with Mets. Odd ratios (OR) for Mets prediction were calculated using stepwise logistic regression analyses.

Results
The incidence of Mets was 18.64% over the 15-year follow-up period.During 15 years’ follow-up, TyG-waist to height ratio (TyG-WHtR) shows the largest AUC for Mets detection (0.686) followed by TyG-waist circumference (TyG-WC) (0.660), TyG-waist-to-hip ratio (TyG-WHpR) (0.564), and TyG index (0.556) in all participants. Gender analysis revealed that TyG-WHtR and TyG-WC have the largest AUC in both genders. TyG-WHtR significantly predicted Mets in all participants, with an unadjusted odds ratio of 5.63 (95% CI 3.23–9.83 P < 0.001). Associations remained significant after adjustment for smoking, drinking, physical exercise and components of Mets.

Conclusions
TyG-WHtR might be a strong and independent predictor for Mets in all participants in an urban Chinese population. TyG-related markers that combine obesity markers with TyG index are superior to other parameters in identifying Mets in both genders.
The effect of probiotics on the clinical status of adult patients with atopic dermatitis: a systematic review
Authors: Sodré Camila Stofella , Vieira Mayra Stambovsky , Estefan Juliany Lima , Moraes Cristiane , Cavalcante Fernanda Sampaio , dos Santos Kátia Regina Netto , de Carvalho Ferreira Dennis 
Published: June 2022

Abstract
Objectives
To describe, through a literature review, the results and benefits of oral and topical probiotics for adult patients with atopic dermatitis.

Design
A systematic review of articles published over a 13-year period was conducted to answer the following questions: (1) what information is given in the scientific literature concerning the use of probiotics in adult patients with atopic dermatitis? (2) Was there an improvement in the clinical status of the patients? (3) Was there a change in the microbial profile in patients after using such approaches? (4) Among the probiotics used, which was the most used in adult AD patients? (5) What was the average time of these interventions? (6) What were the outcomes?

Results
Seven studies with different sample sizes, ranging from 16 to 109 patients, were included in this review. These studies were all clinical trials (7/7), and probiotics (7/7) was the model of intervention chosen. Probiotics showed a potential to relieve the symptoms of the study groups with a reduction of pruritus and SCORAD when compared to the placebo groups. However, their effectiveness varied according to the strain, period, and form of administration.

Conclusions
Many studies have demonstrated that probiotics improve the symptoms of atopic dermatitis and even its prevention. However, there is still much controversy and divergence concerning the real benefits. Despite this, probiotics have demonstrated a fair ability in improving AD adult patients’ symptoms in terms of decreasing pruritus and severity related to SCORAD.
Assessment of the accuracy of imaging software for 3D rendering of the upper airway, usable in orthodontic and craniofacial clinical settings
Authors: Lo Giudice Antonino , Ronsivalle Vincenzo , Gastaldi Giorgio , Leonardi Rosalia 
Published: June 2022

Abstract
Background
Several semi-automatic software are available for the three-dimensional reconstruction of the airway from DICOM files. The aim of this study was to evaluate the accuracy of the segmentation of the upper airway testing four free source and one commercially available semi-automatic software. A total of 20 cone-beam computed tomography (CBCT) were selected to perform semi-automatic segmentation of the upper airway. The software tested were Invesalius, ITK-Snap, Dolphin 3D, 3D Slicer and Seg3D. The same upper airway models were manually segmented (Mimics software) and set as the gold standard (GS) reference of the investigation. A specific 3D imaging technology was used to perform the superimposition between the upper airway model obtained with semi-automatic software and the GS model, and to perform the surface-to-surface matching analysis. The accuracy of semi-automatic segmentation was evaluated calculating the volumetric mean differences (mean bias and limits of agreement) and the percentage of matching of the upper airway models compared to the manual segmentation (GS). Qualitative assessments were performed using color-coded maps. All data were statistically analyzed for software comparisons.

Results
Statistically significant differences were found in the volumetric dimensions of the upper airway models and in the matching percentage among the tested software (p < 0.001). Invesalius was the most accurate software for 3D rendering of the upper airway (mean bias = 1.54 cm3; matching = 90.05%) followed by ITK-Snap (mean bias =  − 2.52 cm3; matching = 84.44%), Seg 3D (mean bias = 3.21 cm3, matching = 87.36%), 3D Slicer (mean bias =  − 4.77 cm3; matching = 82.08%) and Dolphin 3D (difference mean =  − 6.06 cm3; matching = 78.26%). According to the color-coded map, the dis-matched area was mainly located at the most anterior nasal region of the airway. Volumetric data showed excellent inter-software reliability (GS vs semi-automatic software), with coefficient values ranging from 0.904 to 0.993, confirming proportional equivalence with manual segmentation.

Conclusion
Despite the excellent inter-software reliability, different semi-automatic segmentation algorithms could generate different patterns of inaccuracy error (underestimation/overestimation) of the upper airway models. Thus, is unreasonable to expect volumetric agreement among different software packages for the 3D rendering of the upper airway anatomy.
Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study
Authors: Gadelmawla Mohamed H. A. , Alazzouni Ahmed S. , Farag AbdelRazik H. , Gabri Mohamed S. , Hassan Basma N. 
Published: June 2022

Abstract
Background
Colorectal cancer is considered a potential causative agent of morbidity and death, making it a particularly dangerous malignancy. The current study aims to assess the efficacy of ferulic acid (FA) to attenuate the harmful side effect of 5-fluorouracil (5FU) in colon cancer tissues induced by 1,2-dimethylhydrazine (DMH).

Results
Regarding the colon tissues of male Wistar-albino rats (Rattus norvegicus), combined FA and 5FU showed the approximately normal structure of mucosa. The treated groups showed a remarkable reduction in Ki67, Ck20, and an elevation in caspase-3 and P53. There was significant upregulation of P53 in both 5FU and combined FA–5FU groups (p < 0.001 and p < 0.00001, respectively).

Conclusions
The present results revealed a potential role of the combined therapy by 5FU and FA in the suppression of colon cancer induced by DMH by upregulation of apoptosis with the clear effect of FA in attenuating the side effects of 5FU on the normal cells.
An entirely suprasellar Rathke’s cleft cyst: a rare case report with review of literature
Authors: Patankar Amey P. , Chaudhary Shivani 
Published: June 2022

Abstract
Background
A Rathke’s cleft cyst is a benign intrasellar cystic lesion, with suprasellar extension reported in a few cases. An entirely suprasellar Rathke’s cleft cyst without any intrasellar component, though previously reported, is rare.

Case presentation
We report a case of an entirely suprasellar Rathke’s cyst in a 25-year-old female presenting with headache and visual complaints. The patient was treated surgically by drainage of the cyst and removal of the cyst wall by transcranial approach. Histopathology and immunohistochemistry confirmed the diagnosis of Rathke’s cyst. We review the relevant literature and discuss its neuroembryologic pathogenesis, pathology and the factors influencing the recurrence of the cyst.

Conclusions
To the best of our knowledge, only 62 cases of an entirely suprasellar Rathke’s cyst have been reported till date.
Comparison of nalbuphine versus magnesium sulfate as an adjuvant to intrathecal hyperbaric bupivacaine (0.5%) in infraumbilical surgeries
Authors: Kapdi Manisha S. , Shah Devanshi , Desai Shruti 
Published: June 2022

Abstract
Background
Spinal anesthesia with bupivacaine is very common for infraumbilical surgeries. Various adjuvants are added to it to improve the quality of the block and post-operative analgesia. The study period for this study was from October 2017 to March 2018, and it was a randomized double-blinded prospective observational study. In this study, we aim to compare nalbuphine and MgSO4 (magnesium sulfate) as adjuvant to hyperbaric bupivacaine in terms of sensorimotor blockage characteristics, hemodynamic stability, and postoperative analgesia. Ninety patients of ASA grades I and II, between 18 and 60 years of age of either sex posted for elective infraumbilical surgeries, after approval from the institutional review board and written informed consent, were allocated into 3 groups of 30 patients each. With the help of the randomization table, random numbers were generated, and the randomization was done at the time of giving intrathecal anesthesia.
Group A: 3 mL of 0.5% heavy bupivacaine 15 mg + 0.2 mL of 0.9% normal saline to a total volume of 3.2 mL
Group B: 3 mL of 0.5% heavy bupivacaine 15 mg + 0.1 mL of 1 mg preservative-free nalbuphine with 0.1 ml of 0.9% normal saline to a total volume of 3.2 mL
Group C: 3 mL of 0.5% heavy bupivacaine 15 mg + 0.2 ml of 50% preservative-free (100 mg) magnesium sulfate to a total volume of 3.2 mL
The primary outcome was to assess the postoperative analgesia, and the secondary outcome was to assess the perioperative hemodynamic stability and adverse effects during the study period.

Results
The onset of sensory and motor blockade was earlier in the nalbuphine group as compared with the other two groups. It was also observed that the duration of postoperative analgesia was longer in the patients who received magnesium sulfate as compared with the patients in the other two groups. Adverse effects (pruritus, nausea, vomiting) were more in the nalbuphine group as compared with the other two groups.

Conclusions
In a nutshell, preservative-free intrathecal 1 mg nalbuphine and 100 mg magnesium sulfate both are good adjuvants to hyperbaric bupivacaine. Nalbuphine provides faster sensory and motor onset than magnesium sulfate, whereas magnesium sulfate provides prolonged postoperative analgesia than nalbuphine.
Examining the usability and viability of using a simulated classroom environment to prepare preservice science teachers during and after the COVID-19 pandemic
Authors: Mikeska Jamie N. , Howell Heather , Kinsey Devon 
Published: June 2022

AbstractEducator preparation programs experienced extreme challenges during the COVID-19 pandemic, as many universities and K-12 schools moved to fully online or hybrid instructional models. These abrupt changes significantly limited preservice teachers’ opportunities to engage in classroom-based practice teaching experiences, which are a bedrock of educator preparation programs to support preservice teachers in learning how to teach effectively. In this study, we examined the usability and viability of integrating simulated teaching experiences, which occur in an online, virtual classroom environment consisting of five student avatars, into elementary science method courses during the COVID-19 pandemic to prepare preservice science teachers to engage in one critical science teaching practice: facilitating discussions that engage students in scientific argumentation. This study uses qualitative content analysis of survey data and a focus group interview to identify patterns and themes in how four elementary science teacher educators and 49 of their preservice teachers perceived the use of this tool within elementary science teacher education, particularly the opportunities and challenges this tool afforded during the pandemic and possibilities for use in the post-COVID era. Study findings suggest that these elementary science teacher educators and preservice teachers perceived the simulated teaching experience as valuable for supporting teacher learning, addressing COVID-related challenges, and tackling perennial challenges in science teacher education. They also noted challenges related to implementation and concerns with future access. A discussion of key factors that may support and hinder the use of such tools within elementary science teacher education and implications for leveraging lessons learned post-COVID are included.
A psychoeducational intervention for teachers about bullying behavior prevention among secondary school students
Authors: El Fatah Wafaa Osman Abd , El-Maksoud Mona Mohamed Abd , Elkhalek Hanem Ahmed Abd 
Published: June 2022

Abstract
Background
Bullying among peers in schools is a significant public health problem that contributes to unhealthy outcomes for those who bully or are bullied.

Aim
The aim of the study is to evaluate the effect of a psychoeducational intervention for teachers about bullying behavior prevention among secondary school students.

Results
The present study shows that there is highly statistical significance between total intervention regarding bullying at school and total bullying perceptions post-psychoeducational intervention.

Conclusions
It is important for teachers to receive a psychoeducational intervention from time to time to help them teach students how to solve their problems that can redirect potentially negative or passive behaviors to positive problem-solving and leadership skills.
Autistic traits and obsessive-compulsive personality traits in OCD patients
Authors: Abd Elgawad A. , Elbatrawy A. , Shorub E. , Ramadan M. , Elkhatib H. 
Published: June 2022

Abstract
Background
Studies have reported a high prevalence of autism spectrum disorder in young people with obsessive-compulsive disorder with a negative effect on psychosocial functioning. However, the extent to which autism spectrum disorder and obsessive-compulsive personality disorder traits overlap and by inference, the extent to which these separately classified Diagnostic and Statistical Manual of Mental Disorders disorders five (obsessive-compulsive personality disorder, personality disorder, autism spectrum disorder, neurodevelopmental disorder) may share a nosological relationship has not so far been systematically investigated in clinical samples.
This study is done to detect the frequency of obsessive-compulsive personality traits and autistic traits in a sample of patients with obsessive-compulsive disorder.

Results
Results revealed that younger patients had significantly more severe and extreme obsessive-compulsive disorder scores. Moreover, Structured Clinical Interview for DSM-IV (SCID-II) and Autism Spectrum Quotient analysis revealed that younger patients had a significantly higher prevalence of personality traits and autistic traits respectively. Statistical significance as many patients with severe and extreme Yale-Brown Obsessive-Compulsive Scale showed criteria of obsessive-compulsive personality disorder. No association of statistical significance was found between obsessive-compulsive disorder severity and autistic trait presence. On the contrary, statistical significance was found between autistic traits and obsessive-compulsive personality disorder.

Conclusions
There is the presence of comorbidity of obsessive-compulsive personality traits and autism spectrum traits in obsessive-compulsive disorder patients. Obsessive-compulsive personality traits prevalence in obsessive-compulsive disorder patients was higher than in autistic traits. Several factors of genetic predisposition, environmental factors like education and marital status, employment, and intrinsic factors as age of patients all exhibited a pivotal role in obsessive-compulsive disorder prevalence and severity.
Thermal and gastric stability of antimicrobial activity of juices and aqueous extracts prepared from common eligible herbs and traditional medicinal plants against Burkholderia pseudomallei and other enteric bacteria
Authors: Trinh Trung Thanh , Vu Tai Anh , Bui Linh Nguyen Hai , Nguyen Ha Viet , Nguyen Dzung Tuan Huu , Dang Nghiem Xuan , Le Tran Quyen Thi 
Published: June 2022

Abstract
Background
Burkholderia pseudomallei is a causative agent of melioidosis, a fatal infectious disease highly prevalent in the tropics where traditional medicinal plants are widely used for the treatment of various human ailments. In this study, we aimed to evaluate the in vitro antibacterial activity of common eligible herbs and medicinal plants against B. pseudomallei. Thermal and gastric stability, antibacterial spectrum, bactericidal activity, and cell cytotoxicity were also tested to verify the possible usage of these plants in the treatment of melioidosis.

Results
Eighteen eligible herbs and twenty-one medicinal plants were collected. Herb juices and aqueous plant samples extracted at different temperatures were prepared for antibacterial testing. A higher proportion of aqueous plant extracts (17/21; 80.9%) against B. pseudomallei was observed, in comparison with that of herb juices (8/18; 44.5%). Two herb juices and twelve aqueous plant extracts were selected for further tests. The juices of A. sativum and A. tuberosum decreased their antimicrobial activity when treated at higher temperatures whereas the aqueous plant extracts increased their antimicrobial activity when prepared at 70 and 100 °C. The herb juices showed a broader spectrum of antimicrobial activity than the aqueous plant extracts. All samples showed less cytotoxicity on the HT29, HepG2, and HEK293 cell lines. At the 2× minimal inhibitory concentration (MIC), aqueous extracts of Blechnum orientale, Breynia fruticose, Psidium guajava, Rhodomyrtus tomentosa, Rosa odorata, and Schima wallichii showed similar bactericidal activity to that of amoxicillin clavulanic acid. The antimicrobial activity of Mangifera indica, Punica granatum, and R. tomentosa remained under the stimulated gastric conditions.

Conclusion
Our data indicate that traditional medicinal plants prepared by decoction could be effectively used to treat melioidosis via the oral route. Further in vivo investigations are needed to explore other alternative therapies for the prevention and treatment of tested pathogenic bacterial species.
The Lower Devonian (Ovinparmian) reservoir: Prospects in the offshore part of the Timan-Pechora petroleum basin
Authors: Vilesov Aleksandr Petrovich , Zagranovskaya Dzhulia Egorovna , Rasskazova Svetlana Nikolaevna , Stepanova Valeria Sergeevna , Zakharova Oksana Aleksandrovna , Shashel Vadim Aleksandrovich 
Published: June 2022

The offshore part of the Timan-Pechora petroleum basin is one of the most promising areas to search for new petroleum accumulations. The commercial potential of the Carboniferous-Lower Permian play has already been proven by exploratory drilling in the Dolginskoye uplift, whereas the Prirazlomnoye field has been in production since 2013. However, significant petroleum resources in this area may be confined to the Ordovician-Lower Devonian play. The purpose of the study is to evaluate the potential of the Lower Devonian (Ovinparmian) reservoirs within the Pechora Sea shelf based on new geologic and geophysical data. We identified multiple prospects within the Dolginsko-Papaninskaya structural zone and estimated its resources. The potential of the Lower Devonian within the study area is comparable with that of the Carboniferous-Lower Permian play. Based on the new 3D seismic data performed in three offshore license blocks, we identified several unconformities, where the Timanian-Sargaevian regional seal onlaps carbonate rocks of the Ovinparmian horizon (Lochkovian stage, Lower Devonian). We hypothesize that due to the Middle Devonian structural deformations, the Lower Devonian carbonate deposits have been exposed to subaerial erosion and surface and subsurface karst. Diagenetic alterations of the Ovinparmian sediments (i.e., dolomitization, dissolution, and fracturing) are favorable for the development of high-porosity reservoirs. In our study, we consider some sedimentation, diagenesis, and catagenesis models of the Ovinparmian carbonates. Furthermore, we designed an exploration program with a view to further study the Lower Devonian reservoirs.
A Three-Gene Signature Predicts Response to Selinexor in Multiple Myeloma
Authors: Restrepo Paula , Bhalla Sherry , Ghodke-Puranik Yogita , Aleman Adolfo , Leshchenko Violetta , Melnekoff David T. , Agte Sarita , Jiang Joy , Madduri Deepu , Richter Joshua , Richard Shambavi , Chari Ajai , Cho Hearn Jay , Jagannath Sundar , Walker Christopher J. , Landesman Yosef , Laganà Alessandro , Parekh Samir 
Published: June 2022

PURPOSE Selinexor is the first selective inhibitor of nuclear export to be approved for the treatment of relapsed or refractory multiple myeloma (MM). Currently, there are no known genomic biomarkers or assays to help select MM patients at higher likelihood of response to selinexor. Here, we aimed to characterize the transcriptomic correlates of response to selinexor-based therapy. METHODS We performed RNA sequencing on CD138+ cells from the bone marrow of 100 patients with MM who participated in the BOSTON study, followed by differential gene expression and pathway analysis. Using the differentially expressed genes, we used cox proportional hazard models to identify a gene signature predictive of response to selinexor, followed by validation in external cohorts. RESULTS The three-gene signature predicts response to selinexor-based therapy in patients with MM in the BOSTON cohort. Then, we validated this gene signature in 64 patients from the STORM cohort of triple-class refractory MM and additionally in an external cohort of 35 patients treated in a real-world setting outside of clinical trials. We found that the signature tracks with both depth and duration of response, and it also validates in a different tumor type using a cohort of pretreatment tumors from patients with recurrent glioblastoma. Furthermore, the genes involved in the signature, WNT10A, DUSP1, and ETV7, reveal a potential mechanism through upregulated interferon-mediated apoptotic signaling that may prime tumors to respond to selinexor-based therapy. CONCLUSION In this study, we present a present a novel, three-gene expression signature that predicts selinexor response in MM. This signature has important clinical relevance as it could identify patients with cancer who are most likely to benefit from treatment with selinexor-based therapy.