bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Serum Long-Chain Fatty Acids with Multiple Organ Involvements in Patients with Sarcoidosis
Authors: Suzuki Takahito , Karayama Masato , Inoue Yusuke , Hozumi Hironao , Suzuki Yuzo , Furuhashi Kazuki , Fujisawa Tomoyuki , Enomoto Noriyuki , Nakamura Yutaro , Inui Naoki , Suda Takafumi 
Published: March 2022

Abstract
Background
Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis.
Methods
The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated.
Results
The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission.
Conclusions
Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity.
Application and Feasibility of Bedside Cranial Ultrasound in Patients with a Translucent Cranial Implant: A Potential Path for an Introduction of a “Neurosurgical Stethoscope”
Authors: Doron Omer , Rosenberg Ashley , D’Amico Randy S , Langer David J 
Published: March 2022

Abstract
Background: Imaging is the cornerstone of management of neurosurgical patients. The use of ultrasound (US) in neurosurgery can potentially avoid some of the disadvantages of computed tomography (CT), including the need for patient transport, and radiation exposure. Traditionally limited in neurosurgical patients due to lack of skull penetrance, the recent introduction of translucent cranial implants can facilitate acoustic-based imaging. Objective: In this study, we sought to examine the feasibility of a bed-side US done post-operatively in patients with translucent cranial implants, and to qualitatively compare the accuracy of this modality in diagnosing basic neurosurgical “red flags” on imaging, to a head CT.Methods: We reviewed 5 cases operated in our institution which underwent implantation of sonolucent cranial implants. Implant size ranged from a burr hole cover to a fronto-temporo-parietal cranioplasty implant (2 – 15cm). Indications for surgery included: normal pressure hydrocephalus, complex hydrocephalus, superficial temporal artery to middle cerebral artery bypass, resection of a falcine meningioma and cranioplasty after decompressive hemicraniectomy. Patients were scanned by ultrasound between post-operative days 1 and 3, immediately prior to a CT scan ordered for a change in clinical status based on attending neurosurgeon’s decision. Results: Relevant anatomy correlated between US and CT in all cases. This included: ventricles contour and size, midline shift, the presence of a mass or mass effect, and catheter tip position when available. Bedside US evaluations were all obtained within 5 minutes (range: 2:00 – 5:30 minutes:seconds) using a handheld probe with standard sonication settings and minimal patient discomfort.Conclusion: Cranial sonolucent implants create an opportunity to use bedside US as a non-invasive imaging modality capable of enhancing the post-operative neurosurgical exam in an acute setting. Further study is needed to refine the use of this modality and characterize the relative advantages it may offer for neurosurgical patients.
Bacterial volatiles elicit differential olfactory responses in insect species from the same and different trophic levels
Authors: Neerbos Francine Antoinette Cornelus van , Dewitte Peter , Wäckers Felix , Wenseleers Tom , Jacquemyn Hans , Lievens Bart 
Published: March 2022

Abstract
Insect communities consist of several trophic levels that have to forage for suitable resources among and within larger patches of non-resources. To locate their resources, insects use diverse stimuli, including olfactory, visual, acoustic, tactile and gustatory cues. While most research has focused on cues derived from plants and other insects, there is mounting evidence that insects also respond to volatile organic compounds (VOCs) emitted by microorganisms. However, to date only very little is known about the olfactory responses of insects to microbial VOCs within and across different trophic levels. In this study, using Y-tube bioassays and chemical analysis of VOCs we assessed how volatile compounds emitted by bacteria affect the olfactory response of insects of different trophic levels. Experiments were performed using two aphid species (Amphorophora idaei and Myzus persicae var. nicotianae), their most important primary parasitoid species (Aphidius colemani, A. ervi, and A. matricariae), and two of their hyperparasitoid species (Asaphes suspensus and Dendrocerus aphidum). Olfactory responses were evaluated for three bacterial strains (Bacillus pumilus ST18.16/133, Curtobacterium sp. ST18.16/085, and Staphylococcus saprophyticus ST18.16/160) isolated from the habitat of the insects. Results revealed that insects from all trophic levels responded to bacterial volatiles, but responses varied between and within trophic levels. All bacteria produced the same set of volatile compounds but often in different relative concentrations. For a number of these volatiles we found contrasting correlations between their concentration and the behaviour of the primary parasitoids and hyperparasitoids. Exploitation of such contrasting responses may lead to novel semiochemical-based strategies to improve biological aphid control.
Serum glycated albumin is associated with in-stent restenosis in patients with acute coronary syndrome after percutaneous coronary intervention with drug-eluting stents : An observational study
Authors: Lin Xiao Long , Li Qiu Yu , Sun Hao Xuan , Zhao Dong Hui , Liu Jing Hua , Fan Qian 
Published: March 2022

Abstract
Background: Glycated albumin (GA) is a useful glycaemic index that reflects short-term blood glucose control. Previous studies have been confirmed the predicted value of GA in atherosclerotic cardiovascular disease (ASCVD). However, The relationship between GA and the development of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation has not been verified in patients with the acute coronary syndrome (ACS).Method: A total of 797 patients diagnosed with ACS who underwent re-coronary angiography more than six months after the first successful DES-based percutaneous coronary intervention (PCI) were eventually included in this study. Patients were categorized into two groups based on the median GA levels of 14.94%. Moreover, multivariate logistic regression analysis models, the net reclassification improvement (NRI) and integrated differentiation improvement (IDI) risk models were also constructed to assess the relationship between the GA and DES-ISR with ACS patients.Results: A total of 202 ( 25.3%) patients had DES-ISR during the follow-up period. The GA was significantly association with an increased risk of DES-ISR, Upon adjusting for confounding factors (As nominal variate: OR 1.868, 95% CI 1.191–2.932, P = 0.007; As continuous variate: OR 1.109, 95% CI 1.040–1.183, P =0.002). The addition of GA to a baseline risk model and an incremental effect on the predictive value for DES-ISR (AUC: GA vs. Baseline model, 0.714 vs. 0.692, comparison P = 0.017; Category-free net reclassification improvement (NRI) 0.080, P = 0.035; integrated discrimination improvement (IDI) 0.023, P < 0.001).Conclusion: GA level was significantly associated with a high risk of DES-ISR in patients with ACS treated with PCI. Moreover, the addition of the GA to a baseline risk model has an incremental effect on the predictive potential for DES-ISR.
Prediction method of radial heat affected zone width in nanosecond pulsed laser ablation of TC4
Authors: Wang Xulin , Jia Zhenyuan , Ma Jianwei , Han Dongxu , Qi Xiaoqian , Gui Chuanheng , Liu Wei 
Published: March 2022

Abstract
Nanosecond pulsed laser ablation (NPLA) is widely used in micromachining. However, during the machining process, the radial heat-affected zone (RHAZ) will deteriorate the machining quality and accuracy of the microgroove, which is the basic unit of the ridge surface used to reduce frictional resistance in spacecraft walls. Its effective prediction is crucial for the processing precision control of microgrooves to ensure the drag reduction performance of the ridge surface. For this reason, this paper proposes an effective method to predict the RHAZ width. TC4, commonly used in aerospace, is the target material in this work. By comprehensively considering the thermal accumulation effect of laser pulses and the superimposability of the temperature field, and based on the point heat source method, a dynamic temperature distribution model in NPLA is established. Then, the RHAZ width is initially predicted by combining the graphical method and the RHAZ definition. Finally, to improve the prediction accuracy of the RHAZ width. A correction factor is obtained by the NPLA of microgrooves on TC4. The relative error between the predicted RHAZ width and observed values is less than 7% after introducing the correction factor, which verifies the reliability and validity of the proposed prediction method for the RHAZ width. Furthermore, the RHAZ width in NPLA of TC4 is on the order of hundreds of microns, which should be considered to ensure its processing quality when the ridge surface is designed on TC4. The research method in this paper will guide the design of high-density functional patterns and their high-precision preparation and has significant engineering practical value.
Study on helical hole-making process of CFRP/Al alloy laminated materials
Authors: Li Xue , Jiao Anyuan , Liu Binghong , Zhang Yue , Liu Guojun , Zhang Zhen 
Published: March 2022

Abstract
To ensure assembly accuracy and efficiency, lots of holes are made directly on the laminated material composed of CFRP and Al alloys. However, because the different laminated sequence, the optimal process parameters are also different, which affects the hole-making quality of the laminated materials. First, the motion of helical milling was analyzed. Level values of influence the quality of the hole-making are determined, such as spindle speed, pitch and preload. The response surface method (RSM) was used to design experiments, and the burr height between Al alloy interlayer and the tear value of CFRP were used as the standard to analyze the experimental results. The optimal parameters combination for different laminated sequences were predicted and used for cutting force analysis. Secondly, the hole-making processes with variable parameters study were carried out, and the method of micro-lifting tool is proposed for the experimental study of the sudden change of axial force in the transition between interlayer with constant parameters. The results show that the aperture of the hole-making with variable parameters of the laminated materials using the optimal process parameters all meets the H9. The interlayer burr of the Al alloy and the tear value of the CFRP at the entrance and exit conform to the technical requirements. The hole-making axial forces of the laminated material are less than 50 N and 60 N, which are 70% and 83% of constant parameters milling. The effectively reduce the sudden change of axial force between interlayer.
Blast-Induced Ground Vibration Prediction and Uncertainty Quantification in Granite Quarries Using Deep Ensembles Model
Authors: Erten Gamze Erdogan , Keser Sinem Bozkurt , Yavuz Mahmut 
Published: March 2022

Abstract
Ground vibration is one of the most dangerous environmental problems associated with blasting operations in mining. Therefore, accurate prediction and controlling the blast-induced ground vibration are imperative for environmental protection and sustainable development. The empirical approaches give inaccurate results as obvious in the literature, hence, numerous researchers have started to use the fast-growing soft computing approaches with satisfying prediction performance. However, not only achieving the high-prediction performance but also detecting prediction uncertainty is very important for especially blasting operations which is a safety-critical system. This study aims to propose the deep ensembles model to predict the blast-induced ground vibration and quantify the prediction uncertainty, which is usually not addressed. The deep ensembles model includes training an ensemble of deep neural networks (DNN) on the same data, by initializing each network randomly, to yield multiple predictions on both the predicted value and the uncertainty value. In this study, 200 published data from ten granite quarry sites in Ibadan and Abeokuta areas, Nigeria were used. The input parameters were the distance from the blasting face and the weight of the charge per delay, while the targeted output was the peak particle velocity (PPV). For comparison, a single DNN model and an empirical equation (USBM equation) were applied. According to the coefficient of determination\({\text{R}}^{2}\), root mean squared error (RMSE), negative log-likelihood (NLL), mean prediction interval width (MPIW), and prediction interval coverage probability (PICP), the deep ensembles model gave both the most accurate predictions and the most reliable predictive uncertainty quantification.
A Simulation Approach To Invent CYP1A1 Gene Variants Affecting The Protein Structure And Stability In Oral Cancer
Authors: Zaker Uzma Shaheen , Padmavathi Pannuru , Singh Narendra , Swamy Kakumani Venkateswara , Singh Shri Abhiav , Badri Kameswara Rao , Reddy Vaddi Damodara 
Published: March 2022

Abstract
Chronic exposure to environmental carcinogens like tobacco smoke and smokeless tobacco increases the CYP1A1 gene expression. The CYP1A1 gene polymorphisms and overexpression have been linked to oral cancer. Non-synonymous polymorphism in the gene coding region affects the structural stability and function of the CYP1A1 protein due to the substitution of amino acids. We screened all the 1693 polymorphisms reported for the CYP1A1 gene and filtered down to 25 Non-synonymous SNPs (nsSNPs) that are relevant in cancer. Further, we investigated all 25 SNPs using various in silico methods, to predict whether any of these SNPs cause changes in the structure and possible function of the protein. Among the three substitutions, the T461N (rs1799814), I462F (rs1048943) were found to be deleterious and functionally significant, whereas I462V (rs1048943), reported as functionally significant in some populations, but observed as a tolerated neutral variant by in silico analysis. Furthermore, by molecular dynamics simulation, it was observed that T461N and I462F variants lead to structural changes when compared to the native protein and I462V variants. Eventually, these nsSNPs in CYP1A1 would provide prior information for identifying the functionally valid SNPs as a genetic risk factor and may be targeted for cancer prevention studies and therapies.
Geochemical Numerical Simulation of Low Salinity Waterflooding in Sandstone Reservoirs
Authors: Elagab Oubai Mishal Abdelrasool 
Published: March 2022

Abstract
In this paper, the underlying mechanisms behind the low salinity waterflooding were investigated. It has been ascertained that wettability alteration towards more water-wet is the leading cause to enhance oil recovery and observe the low salinity effect (LSE). The double-layer expansion mechanism has been considered the most probable reason for the wettability alteration due to low salinity waterflooding. Therefore, mechanistic modeling of low salinity waterflooding was approached by developing a diffuse layer surface complexation-based model that accounts for the double-layer expansion phenomena. The model was developed using the geochemical reaction path code PHREEQC, wherein the speciation and surface charge development at the oil-brine and kaolinite-brine interfaces were determined. Consequently, both the electrostatic pair linkages and the electrostatic forces were calculated, which led to predicting the qualitative change in the rock wetness owing to the low salinity effect. Wettability alteration owing to low salinity water flooding was predicted as a function of the oil composition, pH environment, ionic strength, divalent ions of the injected brine, and the concentration of the divalent cations in the formation water. The wettability change was qualitatively estimated using three approaches: bond product sum, zeta potential, and stability number.Overall, the high levels of pH in the system and the high acid content in the oil composition proved to have a beneficial impact in observing the low salinity effect and thus wettability alteration towards more water-wet. In contrast, increasing the ionic strength and the divalent cation concentrations at both formation water and injected brine suppressed the low salinity effect. Also, the abundance of Ca+2 in the formation water was more pronounced than Mg+2 to suppress the LSE. The results also showed that the bond product sum approach could not predict the wettability alteration owing to low salinity waterflooding when the pH level is higher than five.
Filamentous Crystal Growth In Organic Liquids And Selection Of Crystal Morphology
Authors: Yashima Takumi , Tani Marie , Kurita Rei 
Published: March 2022

Abstract
Filamentous crystals such as whisker crystals are often seen not only in metallic liquids, but also in organic liquids and solutions. They are interested as reinforce materials. However, it remains challenging to induce filamentous crystals due to an incomplete understanding of the mechanisms behind their formation. In this paper, we investigate filamentous crystal growth in viscous organic liquids. It is found that filamentous crystals grow via an extraordinary dynamical path, where the molecules locally evaporate to bubbles and then redeposite to the tip of growing crystalline filaments. We also succeeded in controlling whether filamentous or faceted crystal growth is selected by inducing or suppressing the bubbles.
Cryoglobulinemia in Systemic Lupus Erythematosus: A Retrospective Study of 213 Patients
Authors: Roubertou Yoann , Sabine Mainbourg , Hot Arnaud , Fouque Denis , Confavreux Cyrille , Chapurlat Roland , Debarbieux Sebastien , Jullien Denis , Sève Pascal , Juillard Laurent , Kolopp-Sarda Marie-Nathalie , Lega Jean-Christophe 
Published: March 2022

Abstract
Objectives
The clinical value of cryoglobulinemia (CG) in systemic lupus erythematosus (SLE) is largely unknown. The aim of this retrospective study was to describe the characteristics of CG in SLE, its impact on SLE phenotype, and the features associated with cryoglobulinemic vasculitis (CryoVas) in SLE patients.
Methods
This retrospective study conducted in a French university hospital, reviewed the data from 213 SLE patients having been screened for CG between January, 2013 and December, 2017. SLE patients positive for CG were compared to SLE patients without CG. Patients were classified as CryoVas using the criteria of De Vita et al.
Results
Of the 213 SLE patients included (mean age 28 years, female sex 85%), 142 (66%) had at least one positive CG in their history, 67% of them having a persistent CG at follow-up. CG was type III in 114 (80%) cases and type II in 27 (19%) cases. The mean concentration of the cryoprecipitate was 40mg/L (range 0-228). Patients with CG had significantly more complement consumption for C3, C4, and CH50 and received more corticosteroids (p = 0.002) and rituximab (p = 0.02) during follow-up. Among patients with CG, 21 (15%) developed a CryoVas. These patients had a higher SLEDAI at SLE diagnosis than CG + patients without CryoVas (17 vs. 13.6, respectively, p = 0.03). The clinical involvement of patients with CryoVas was mainly cutaneous (purpura, ulcers, digital ischemia) and articular, without any death at follow-up. Severe manifestations of CG included glomerulonephritis in 1/21 (5%) patient and central nervous system involvement in 4/21 (19%) patients. A response to first line treatments was observed in 12/13 (92%) patients; but relapses were observed for 3 of them.
Conclusion
CG is frequent in SLE, but mostly asymptomatic. CryoVas features involve mostly joints, skin, and general symptoms. CryoVas in SLE appears to be a specific condition, with a low prevalence of neuropathy, membranoproliferative glomerulonephritis, and severe involvement.
Social inequality in Health: Non-Communicable Diseases in Bolivia, determinants, and current challenges at the Municipal
Authors: Eyzaguirre Soraya Roman , Olivera Pamela Córdova 
Published: March 2022

Abstract
Background: The social gradient of Non-Communicable Diseases (NCD) has been widely studied. However, little has been done to understand health inequality across populations within a country, such as between municipalities. We use Bolivian municipal data to analyze the social inequality in the incidence of NCDs and identify social determinants that contribute to this inequality.Methods: First, we estimate curves and concentration indices (CI) of NCDs incidence, measuring the municipal socioeconomic status by the index of Unsatisfied Basic Needs. We rank municipalities from the poorest to the least poor. Then, we decompose the CI into some of its main social determinants using Wagstaff decomposition analysis. The information related to the incidence of NCDs is from the National Health Management Information System (HMI). Incidence rates are standardized by municipal demographics and availability of health services to control for these confounders during the analysis. Socioeconomic data at the municipal level for 2018 comes from the National Institute of Statistics, Sustainable Development Solutions Network - Bolivia, and projections.Results: The CI for NCDs incidence is 0.20 (95% confidence interval: [0.06,0.34]), which shows that the population with NCDs concentrates in relatively less poor municipalities. Consistent with global patterns, hypertension and diabetes have the highest incidence and inequality. We separate the contribution of five social determinants to the inequality of hypertension and diabetes: (1) urbanization rate, (2) education, (3) indigenous people, (4) sanitation, and (5) the percentage of women with anemia. We find that the most relevant are the urbanization rate and education. The rate of urbanization contributes positively to inequality, while years of education contribute negatively. Conclusion: There is an unequal distribution of NCDs that disadvantages municipalities of higher socioeconomic status. One of the main determinants is the urbanization rate. These results are consistent with the hypothesis that, in developing countries, rapid and unplanned urbanization tends to change people’s way of life, potentially leading them to develop behavioral risk factors that contribute to the incidence of NCDs. Thus, policies on healthy urban environments and health education focused on municipalities with high incidence could help to curb the increase of NCDs in Bolivia.