bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Concerns and Health Needs of Transgender
Authors: Ahmad Mansoor 
Published: March 2022

Abstract
Transgender people are a diverse population of individuals who cross or transcend culturally defined categories of gender. Transgender is often used as an umbrella term to signify individuals who defy rigid, binary gender constructions and who express or present a breaking and blurring of culturally prevalent stereotypically gender roles. Since time immemorial people belonging to transgender category face a wide variety of discriminatory barriers in enjoying full equality throughout the World. Their social exclusion from the mainstream society is being documented in the modern epoch, especially spotlighting social barriers and disabilities in attaining opportunities for a socially productive life. They experience stigmatization, discrimination, sexual abuse, lack of civil rights and harassment accessing health services due to their transgender identity. According to WHO, transgender have lower access to health and HIV services due to a range of issues including legal barriers and stigma and discrimination. WHO works with international and country partners to address the varied health needs of transgender, including HIV prevention, diagnosis and treatment and also to address structural barriers which impact service access by transgender (WHO, 2019). Therefore, the aim of this study is to explore the health needs of transgenders and the barriers and issues faced by transgenders while accessing health services, considering the social aspects of transgender. This study employed quantitative methods, which involved 120 in-depth interviews and focus group discussions conducted in various parts of Kashmir. The thematic analysis of data revealed that transgenders had to face severe social and cultural, mental, physical and financial problems in relation to the health care needs.
Elevated Histamine Etiology Model for Most Major Vaccine Associated Adverse Events including SARS-CoV-2 Spike Vaccines
Authors: Ricke Darrell O. 
Published: March 2022

Abstract
Vaccinees experience no adverse events, mild adverse events, multiple adverse events, or serious adverse events post vaccination. Many of these vaccine adverse events occur with different vaccines with different occurrence frequencies. Many of these adverse events are generally considered as associated with immune responses to the active vaccine components (antigens) and/or to possibly one or more of the vaccine excipients. Most of these vaccine adverse events are self-limiting and resolve within days. Many of these adverse events symptoms overlap symptoms associated with elevated histamine levels. Based on these observations, the hypothesis that the majority of vaccine associated reactogenicity adverse events are caused by temporal histamine intolerance in vaccinees is proposed. This hypothesis is based on a model of innate immune responses releasing a surge of inflammatory molecules including histamine; this surge is hypothesized to exceed the normal histamine tolerance level for vaccinees with reactogenicity adverse events. Further, these symptoms resolve as histamine levels fall below the vaccinee’s tolerance threshold. This model can be evaluated by the detection of elevated histamine levels in vaccinees corresponding to timing of symptoms onset. If confirmed, a direct consequence of this model predicts that some antihistamine treatments, mast cell stabilizers, and possibly diamine oxidase enzyme may reduce the incidence or severity of adverse events experienced by vaccinees post vaccinations for most or all high reactogenicity vaccines including coronavirus disease 2019 (COVID-19) Spike vaccines.
Strong Correlations in a Biological System as a Cause of Sustained Epidemic Waves: Implications for Understanding the COVID-19 Pandemic
Authors: Dimaschko Juri , Shlyakhover Vladimir , Iabluchanskyi Mykola 
Published: March 2022

Abstract
We consider an epidemic in a strongly correlated biological system, where the influence of the environment on the individual state and immune response of the infected is decisive. This leads to the 3D Lotka-Volterra system and explains the existence of sustained epidemic waves that are absent in the conventional SIRS model. Taking the biological correlations into account turns the population into a single organism, as a result of which the course of the epidemic reproduces all phases of an individual's infection. We argue that strong correlation effects are critical in shaping the COVID-19 epidemic, which is adequately described by the 3D Lotka-Volterra equations.
Finding Correlation in Clinical and Pathological Diagnosis in Reemerging Context of Leprosy in India: A Tertiary Care Center Experience
Authors: Prajapati Ajeet Kumar , Afrose Ruquiya , Maurya Geeta , Khan Nazoora , Alam Kiran 
Published: March 2022

Background:
Leprosy was supposed to be eliminated by WHO from the world by the end of the year 2000. However, it still affects the major population in India. It is well realized that even after elimination target has been achieved, new leprosy cases will keep coming for at least some years due to continuation of some level of disease transmission or manifestation of disease by subclinical cases. Hence there is the need to review this disease with proper understanding.
Objective:
To determine the current leprosy profile and its relation between clinical and pathological diagnosis, at our centre catering the population of Western Uttar Pradesh.
Methods and Material:
It’s a retrospective study and was carried out on skin biopsy samples sent for histopathological diagnosis in clinical suspicion of leprosy at Jawaharlal Nehru Medical College and Hospital, Aligarh, from June 2015 to November 2017. Tissue Sections were stained with Haematoxylin and Eosin stain for morphological studies, and modified fite stain to identify acid fast bacilli.
Results:
Out of 325 clinically suspected leprosy cases, we diagnosed leprosy in 282 cases with 86.7% parity. Most commonly affected age group was between 16 -30 years (110 cases). Tuberculoid leprosy was the most common histological subtype (69/282, 24.4%) followed by lepromatous leprosy (58/282, 20.56%), borderline tuberculoid (53/282, 18.7%), borderline lepromatous (42/282, 14.8%), indeterminate leprosy (34/282, 12%) and mid borderline leprosy (22/282, 7.8%). Additionally, histioid type of leprosy was diagnosed histologically in 1.4% (4/282) of the cases.
Conclusions:
Identification of suspicious skin patch as leprosy with prompt histological diagnosis especially in population of below 30 years is required for timely intervention and eradication. Both clinician and pathologist should have a focused approach especially in diagnosing indeterminate leprosy.
La inclusión del uso de itinerarios de aprendizaje en Educación Superior
Authors: Villatoro Moral Sofia , De-Benito Crosetti Bárbara 
Published: March 2022

La formación tiene el objetivo de adaptarse al alumnado y a los constantes cambios que están ocurriendo en la sociedad sin dejar de lado la inclusión y la adquisición de competencias en Educación Superior. Este trabajo presenta los datos obtenidos sobre un estudio de caso desarrollado mediante entrevistas a un grupo de alumnos del Grado de Educación Primaria que han desarrollado una asignatura mediante itinerarios de aprendizaje.
Los resultados muestran el grado de satisfacción con la metodología, destacando la flexibilidad en la libre elección de secuencias que componen su itinerario, la importancia del seguimiento docente durante todo el proceso y la planificación como eje principal para finalizarlo. Entre los aspectos positivos señalados por el grupo de estudiantes destacan la evaluación continua, la libre elección de secuencias, el aprendizaje transferible a otros contextos, las tutorías y el seguimiento docente. Por otra parte, los aspectos negativos aparecen con menor frecuencia, pero destacan la carga de trabajo o la preferencia por una evaluación no continuada en algunos casos. Las conclusiones sirven como punto de partida para la creación de un modelo de implementación de itinerarios de aprendizaje y para la realización de mejoras en próximas implementaciones.
Incorporación de las TIC en la formación inicial del profesorado mediante Flipped Classroom para potenciar la educación inclusiva
Authors: Blasco-Serrano Ana Cristina , Bitrián González Irene , Coma-Roselló Teresa 
Published: March 2022

La aplicación pedagógica de la Tecnología de la Información y la Comunicación (TIC) es un importante desafío al que se enfrenta la educación en la actualidad. En este artículo, las TIC se integran en los cursos de educación superior utilizando la estrategia Flipped Classroom (FC). Los estudiantes aprenden la teoría en casa a través de tutoriales en línea antes del trabajo práctico en clase basado en la teoría. También pueden evaluar su propio desempeño utilizando el Sistema de Respuesta de la Audiencia (ARS). El objetivo es profundizar en la inclusión de la tecnología en la formación docente a partir de los modelos TPCK, utilizando FC y ARS. Con un enfoque mixto (cualitativo y cuantitativo), 134 estudiantes de la carrera de Magisterio de Primaria y Diplomatura Profesional participaron en una encuesta ad hoc. Los resultados muestran la importancia del aprendizaje activo, el valor de las tutorías previas a la clase y la calidad de su diseño. Otra ventaja fue que los estudiantes podían recibir retroalimentación durante el proceso de aprendizaje. Los datos indican que esta metodología potencia la atención a la diversidad, mejorando la comprensión y permitiendo que los alumnos aprendan a su propio ritmo.
Los resultados destacan la necesidad de que los docentes reciban formación pedagógica, tecnológica y de contenidos para mejorar sus competencias digitales durante la educación superior inicial.
Understanding factors that contribute to farmers' water conflict behavior
Authors: Tatar Maryam , Papzan Abdolhamid , Ahmadvand Mostafa 
Published: March 2022

AbstractUnderstanding water conflict behaviors and their contributing factors is critical for developing effective agricultural water resource management. Hence, this paper examines how water conflict behaviors are addressed in a model guided by the Theory of Planned Behavior and whether there is a potential to develop the model further to include quality of life (QoL), perception of water crisis, sense of place, and social capital in explaining the farmers' water conflicts. Stratified random sampling was used to survey 212 farmers in the villages that benefited from the Gawshan dam in the Kermanshah region, Iran. Based on the results, the causal role of subjective norms in influencing intention to manifest conflict has not been established, while low social capital was of importance for intention to create conflict. Furthermore, low QoL, as well as high perception of water crisis, was found to be important for attitude formation toward conflict. These results enrich the empirical evidence in support of improving the understanding of farmers' water conflict behaviors.
#TER FÉ SEM AGLOMERAR NO BOMJÉ
Authors: Ramos Silvana Pirillo , Lima Renata Mayara Moreira de 
Published: March 2022

Em 2021, diante da Pandemia de Covid-19 e das restrições sanitárias, a Festa do Bom Jesus dos Navegantes de Penedo/AL, na sua 137ª edição, aconteceu seguindo as recomendações das autoridades de saúde, preservando-se os rituais litúrgicos, mas com cancelamento dos mega shows artísticos, que imprimiu à festividade, ao longo dos anos, o status de evento turístico. Levando isso em consideração, o objetivo desse artigo é analisar o processo de planejamento e organização da Festa em meio a Pandemia de Covid-19 e do aproveitamento das imagens de todo esse processo para a promoção turística de Penedo, por meio das postagens da Prefeitura Municipal no Instagram. Quanto aos procedimentos metodológicos, adotou-se uma abordagem qualitativa de caráter exploratório, com a realização de análise de conteúdo, a partir de leitura flutuante, leitura aprofundada e produção de inferências das postagens realizadas. Os principais resultados evidenciam uma série de adaptações na Festa de Bom Jesus dos Navegantes, mudando-se práticas e rituais religiosos secularmente instituídos. Fica evidente que as ações que buscaram minimizar a aglomeração só foram possíveis em virtude do planejamento conjunto entre gestão pública e diocese local, com o envolvimento de várias secretarias. Verificou-se ainda um paradoxo na promoção da Festa, enquanto festividade religiosa e evento turístico. Ao mesmo tempo em que há a exaltação do “resgate” das tradições, do alinhamento da festividade a sua verdadeira origem; há também uma espetacularização da festa com fotos e vídeos dignos de portfólios de destinos turísticos.
Palavras-chave: Bom Jesus dos Navegantes. Covid-19. Penedo. Promoção do Turismo.
Natural Bioactive Compounds from Medicinal Plants as Antibacterial
Drugs: Mechanism Insights and Clinical Perspectives
Authors: El Omari Nasreddine , Guaouguaou Fatima-Ezzahrae , Bouyahya Abdelhakim 
Published: March 2022

Abstract:
The coevolution in microbes has generated major functional consequences leading bacte-ria to develop resistance to antibiotics. Indeed, bacterial strains have been able to develop and adapt to the action of antibiotics via several resistance mechanisms. In this context, researchers are cur-rently conducting many studies to screen natural antibacterial substances such as secondary metabo-lites of medicinal plants. Indeed, the potential of many plants used in traditional medicine in the treatment of infectious diseases was confirmed experimentally, namely Anethum graveolens, Elet-taria cardamomum, Foeniculum vulgare, Trachyspermum ammi, Viola odorata, Dioscorea dregeana, Cheilanthes viridis, Vernonia colorata, etc. Bioactive molecules from different medicinal plants include terpenoids, flavonoids, and phenolic acids, which were shown to have significant an-ti-bacterial effects. The mechanisms of action of these molecules are different and can include struc-tural, cellular, and molecular levels, which suggests them as real candidates for the development of natural antibiotics. However, the clinical trials of these molecules have not been very well studied which limits their clinical use against infectious diseases of bacterial origin.
Improvement in Polycystic Ovarian Syndrome using Pharmacological and Non- Pharmacological Approaches: Current Perspectives and Principles
Authors: Corrie Leander , Singh Sachin Kumar , Gulati Monica , Awasthi Ankit , Khursheed Rubiya , Kaur Jaskiran , Vishwas Sukriti 
Published: March 2022

Abstract:Polycystic ovarian syndrome (PCOS) is characterized by a wide range of metabolic and endocrine abnormalities, which can be quite complex in the diagnosis and treatment. The pathogenesis of PCOS is unclear. Therefore, symptoms of this condition differ from person to person, and it becomes difficult to treat PCOS. So far, many pharmacological interventions such as antilipidemic, ovulatory stimulants, and oral contraceptives have been used alone or in combination for the treatment of PCOS and have not been significantly effective. Precision medicine could be of importance in the treatment of PCOS, and the use of artificial intelligence could be beneficial in understanding the pathogenesis and management of this condition. Biotechnological interventions using small mRNA have been explored for this condition. Moreover, it is also hypothesized that the gut microbiota has a key role in regulating hormones through the gut-brain axis. Herbal remedies have also been used, but it is limited due to improper standardization. The treatment of PCOS is based on providing symptomatic relief and limiting the perpetuation of this condition. Understanding the use of different interventions is important to bring out better clinical outcomes.
FDG PET/CT Volume-Based Quantitative Data and Survival Analysis in
Breast Cancer Patients: A Systematic Review of the Literature
Authors: Evangelista Laura , Urso Luca , Caracciolo Matteo , Stracuzzi Federica , Panareo Stefano , Cistaro Angelina , Catalano Onofrio 
Published: March 2022

Purpose:
The study aims to assess the role of SUVs, MTV, TLG, and other FDG PET metric
data in predicting the prognosis of patients with newly diagnosed BC.

Materials and methods:
A systematic review was conducted by using three different databases: Pub-
Med, Web of Science, and EMBASE, in the period between January 2011 and May 2021. Studies on
the use of FDG PET in BC patients concerning the utility of metric PET data and survival were retrieved.
The following keywords were used in diverse combinations: “breast cancer”, “18F-FDG”,
“FDG”, “PET”, “PET/CT”, “FDG PET”, “volumetric parameters”, “metabolic tumor volume”,
“MTV”, “total lesion glycolysis”, “TLG”, “prognosis”, “prognostic”. No limits were applied. The
quality of selected papers was assessed by using specific criteria.

Results:
Totally 123 articles were retrieved, but only 14 studies were selected. In the selected papers, overall, the number of patients was 1850. Overall survival (OS) was the main outcome in three studies, while both OS and disease-free survival (DFS) were considered in the remainder of most papers. PET/CT was performed in patients with BC, before surgery or neoadjuvant chemotherapy in 6 studies and in metastatic BC in 8. At multivariable analyses, diverse PET metrics, such as SUVmax, MTV and TLG were correlated to recurrence or OS. However, a large heterogeneity for the proposal cut-off, able to discriminate between poor and good prognosis, was found.

Conclusion:
Totally 123 articles were retrieved, but only 14 studies were selected. In the selected papers,
overall, the number of patients was 1850. Overall survival (OS) was the main outcome in three studies,
while both OS and disease-free survival (DFS) were considered in the remainder of most papers.
PET/CT was performed in patients with BC before surgery or neoadjuvant chemotherapy in 6 studies
and in metastatic BC in 8. At multivariable analyses, diverse PET metrics, such as SUVmax, MTV,
and TLG, were correlated to recurrence or OS. However, a large heterogeneity for the proposal cut-off,
able to discriminate between poor and good prognosis, was found.
B-Cell Lymphoma Associated with COVID‐19 Infection: A Case Report
Authors: Yan Zhihan , Chen Feng , Yang Lili , He Jiawei , Lin Xiaoji , Zhao Dandan , Lin Xianhui 
Published: March 2022

Purpose:
Most common publications are related to COVID-19 diagnosis in hematological
malignancy patients. However, here we report a case involving a patient diagnosed with B-cell lymphoma
while undergoing treatment for COVID‐19, including the changes in major clinical symptoms
and medical examinations, then explain the probable causes of the case.

Case Presentation:
A 74-year-old woman with a previous history of oesophageal cancer was admitted
to the hospital after having cough and sputum for 15 days. Despite the COVID-19 symptoms, this patient
did not have a fever at the time of the onset. Results of routine blood tests were normal at first but
then declined with persistent fever, and A whole-body C.T. examination ruled out the possibility of
tumor-metastasis–related fever. This patient had no hepatosplenomegaly or regional lymphadenopathy,
and there was no concrete evidence of haemophagocytic lymphohistiocytosis or lymphoma until bone
marrow biopsy results confirmed the latter.

Conclusion:
We describe an uncommon case of COVID-19 who was finally diagnosed with B-cell
lymphoma. An awareness of persistent fever and declined routine blood tests caused by hematological
malignancies instead of COVID-19 itself can aid in providing appropriate guidelines for management
and treatment.
Synthesis, Assessment of Antineoplastic Activity, and Molecular Docking
of Novel 2-Thioxo-oxazolidin-4-one Derivatives
Authors: Ramalho Eduardo Augusto Vasconcelos de Freitas , Viana Douglas Carvalho Francisco , Mendonça da Costa Valécia de Cassia , Pitta Maira , Rêgo Moacyr Jesus Barreto de Melo , Pitta Ivan da Rocha , Pitta Marina Galdino da Rocha 
Published: March 2022

Background:
Oxazolidinones display several biological effects, including anticancer activity.
The purpose of this present work was to investigate a series of novel oxazolidinone derivatives
with potential antineoplastic activity. Their mechanisms of death induction and effects in the cell
cycle were also evaluated. A molecular docking study was accomplished through proteins of the
Cyclin-Dependent Kinases family (CDK). The new compound LPSF/NBM-2 was appeared to promote
cell cycle arrest at the G2/M phase and increase the percentage of apoptotic cells.

Methods:
Oxazolidinone derivatives were obtained through Knoevenagel condensation. The cytotoxic
assay was evaluated through the MTT method. Moreover, flow cytometry was performed in order
to investigate the effects of the new compounds on the cell cycle, induction of cell death, and apoptosis.
A blind docking was performed through the SwissDock online server and the analysis of the
results was performed using the UCSF Chimera and Biovia discovery studio software.

Results:
LPSF/NBM-1 and LPSF/NBM-2 displayed the most cytotoxic activity against HL-60 (IC50
= 54.83 μM) and MOLT-4 (IC50 = 51.61 μM) cell lines. LPSF/NBM-2 showed an increased percentage
of cell population at the G2/M phase. Molecular-docking results of LPSF/NBM-1 and
LPSF/NBM-2 suggested a binding affinity with the evaluated CDK proteins.

Conclusion:
LPSF/NBM-1 and LPSF/NBM-2 displayed cytotoxic profiles against Hl-60 and
MOLT-4. LPSF/NBM-2 increased cell population percentage at the G2/M phase and promoted cell
death compared to non-treated cells in the MOLT-4 cell line. Based on these findings, oxazolidinone
derivatives could be highlighted as possible cytostatic agents against lymphoma cells. Molecular
docking results suggested the action of LPSF/NBM-1 and LPSF/NBM-2 compounds on enzymes of
cyclin-dependent kinases family, however, more studies are needed to establish this correlation.