bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Salinity by Using Wavelet Modeling
Authors: Dökmen Funda , ASLAN Zafer 
Published: January 2022

Abstract
Every year, due to the salinity resulting from improper irrigation practices, almost 10 billion ha of agricultural lands across the world cannot be used. Among the main elements (cations) for salinity in regions with dry or semi-dry climate are potassium (K+), sodium (Na+), calcium (Ca+2) and magnesium (Mg+’2). Using proper irrigation methods as well as ensuring the quality of irrigation water are of great importance in terms of the salinity of agricultural soils. In this study, laboratory analyses of ground water resources for salinity parameters were conducted in the province of Yalova (Taşköprü, Çiftlikköy, and Altınova regions). In the explanation of the analysis results, variations and effects based on the level of salinity were taken into account and the role of small, meso and large scale factors were determined through the use of the wavelet model. The study results would be of use in the estimation of salinity contents of soils with respect to groundwater irrigation in agricultural areas.
Erythropoietin in Acute Kidney Injury (EAKI): a Pragmatic Randomized Clinical Trial
Authors: Aoun Mabel , Sleilaty Ghassan , Boueri Celine , Younes Eliane , Gabriel Kim , Kahwaji Reine-Marie , Hilal Najla , Hawi Jenny , Araman Rita , Chelala Dania , Beaini Chadia 
Published: January 2022

Abstract
Background Treatment with erythropoietin is well established for anemia in chronic kidney disease patients but not well studied in acute kidney injury.MethodsThis is a multicenter, randomized, pragmatic controlled clinical trial. It included 134 hospitalized patients with anemia defined as hemoglobin <11 g/dL and acute kidney injury defined as an increase of serum creatinine of 0.3 mg/dL within 48 hours or 1.5 times baseline. One arm received recombinant human erythropoietin 4000 UI subcutaneously every other day (intervention; n=67) and the second received standard of care (control; n=67) during the hospitalization until discharge or death. The primary outcome was the need for transfusion; secondary outcomes were death, renal recovery, need for dialysis.ResultsThere was no statistically significant difference in transfusion need (RR=1.05, 95%CI 0.65,1.68; p=0.855), in renal recovery full or partial (RR=0.96, 95%CI 0.81,1.15; p=0.671), in need for dialysis (RR=11.00, 95%CI 0.62, 195.08; p=0.102) or in death (RR=1.43, 95%CI 0.58,3.53; p=0.440) between the erythropoietin and the control group. ConclusionsErythropoietin treatment had no impact on transfusions, renal recovery or mortality in acute kidney injury patients with anemia. The trial was registered on ClinicalTrials.gov (NCT03401710, 17/01/2018).
Mitotic kinesin-like protein 1, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
Authors: Li Zhi , Yang Hai-Yan , Zhang Xiao-Lan , Zhang Xu , Huang Yu-Zhou , Dai Xin-Yuan , Shi Liang , Zhou Guo-Ren , Wei Ji-Fu , Ding Qiang 
Published: January 2022

Abstract
Background: Triple negative breast cancer (TNBC) is highly malignant and has a worse prognosis, compared with other subtypes of breast cancer due to the absence of therapeutic targets. MKLP1 plays a crucial role in tumorigenesis and cancer progression. However, the role of MKLP1 in triple negative breast cancer and the underlying mechanism remain unknown. The study aimed to elucidate the biological function regulatory mechanism of MKLP1 in triple negative breast cancerMethods: Quantitative real-time PCR and Western blotting were used to determine the MKLP1 expression in breast cancer tissues and cell lines. Then, functional experiments in vitro and in vivo were performed to investigate the effects of MKLP1 on tumor growth and metastasis in triple negative breast cancer. Chromatin immunoprecipitation assay was conducted to illustrate the potential regulatory mechanisms of MKLP1 in triple negative breast cancer.Results: We found that MKLP1 was significantly up-regulated and associated with poor prognosis in triple negative breast cancer. MKLP1 could promote triple negative breast cancer proliferation, migration and invasion in vitro and in vivo. MKLP1 could activate Wnt/β-catenin pathway and promote EMT progression. In addition, FOXM1, upregulated by WDR5 via H3K4me3 modification, directly bound to the promoter of MKLP1 gene to promote its transcription and accelerated TNBC progression via Wnt/β-catenin pathway. Both of small inhibitor of FOXM1 and WDR5 could inhibit TNBC progression. Conclusions: Our findings elucidate WDR5/FOXM1/MKLP1/Wnt/β-catenin axis is associated with TNBC progression and may provide a novel and promising therapeutic target for TNBC treatment.
ReTEECA Trial. Rescue TransEsophageal Echocardiography for In-Hospital Cardiac Arrest.
Authors: Usman Asad Ali , Stein Samantha , Spelde Audrey , Teran-merino Felipe , Augoustides John , Weiss Stuart , Clapp Justin , Vernick William , Abella Benjamin , Gutsche Jacob 
Published: January 2022

Abstract
This trial is aimed at studying the utility and interventional outcomes of rescue transesophageal echocardiography (RescueTEE) to aid in diagnosis, change in management, and outcomes during CPR by using a point of care RescueTEE protocol in the evaluation of in-hospital cardiac arrest (IHCA). This is an interventional prospective convenience sampled partially blinded phase II clinical trial with primary outcomes of survival to hospital discharge (SHD) with RescueTEE image guided ACLS versus conventional ACLS.
Breast Filariasis Presenting Fibroadenoma like Nodules: A Rare Diagnosis
Authors: KUMAR PRABHAT , Priyadharisini J , Singh Ashish Ranjan 
Published: January 2022

Abstract
India has still not eradicated filariasis, which is still endemic throughout the country. This study focuses on the breast as a non-typical but not uncommon site of breast disease characterized by nematodes causing obstruction of lymphatic vessels caused by filariasis. The case described herein involves a 26-year-old married female who presented as a subcutaneous nodule in her left breast. Clinical interrogation of this case as part of the pathological diagnosis, phlebotomy was performed by venepuncture in order to examine peripheral blood smears under a microscope. Nonetheless, the peripheral blood smear did not show microfilariae of the disease. Furthermore, fine needle aspiration cytology was also performed to identify possible things for the study. It was diagnosed that filariasis with fibroadenoma was found to be carrying microfilariae present in fine-needle aspiration cytology smears of various lesions. Conclusively the lymphatic swelling was confirmed to be caused by Wuchereria bancrofti in fine-needle aspiration cytology examination without evidence in peripheral blood smears. It was shown that the subject had filariasis, and the patient responded well to daily treatment with diethylcarbamazine citrate for 42 days.
Documenting Research Software in Engineering Science
Authors: Hermann Sibylle , Fehr Jörg 
Published: January 2022

Abstract
The reuse of research software needs good documentation, however, the documentation in particular is often criticized. Especially in non-IT specific disciplines, the lack of documentation is attributed to the lack of training, the lack of time or missing rewards. This article addresses the hypothesis that scientists do document but do not know exactly what they need to document, why, and for whom. In order to evaluate the actual documentation practice of research software, we examined existing recommendations, and we evaluated their implementation in everyday practice using a concrete example from the engineering sciences and compared the findings with best practice examples. In order to get a broad overview of what documentation of research software entailed, we defined categories and used them to conduct the research. Our results show that the big picture of what documentation of research software means is missing. Recommendations do not consider the important role of developers whose documentation takes mainly place in their research articles. Moreover, we show that research software always has a history that influences the documentation.
Applying Runthrough Guidewire To Transseptal Puncture Without Iodinated Contrast Agent
Authors: wang Jinfeng , Fang Ping , Liu Jichun , Wei Youquan , Wang Xianghai , Yang Hao 
Published: January 2022

Abstract
Aims: Conventional transseptal puncture(TSP) relies on fluoroscopy and iodinated contrast agent to distinctly position the transseptal needle at the left atrium, however, there exists great challenges in clinic in patients with contrast hypersensitivity or allergy-like reactionsin the procedure. This study aimed to evaluate a novel approach to TSP assisted by Runthrough guidewire and fluoroscopy without use of iodinated contrast agent. Methods: Sixty patients with paroxysmal atrial fibrillation undergone radiofrequency catheter ablation were enrolled from February 2021 to October 2021, and randomised to routine TSP group and Runthrough guidewire assisted group. The two groups were compared regarding the total operative time, length of fluoroscopy exposure, difference of radiation dose in X-ray, and the safety was evaluated in the patients undergone TSP without iodinated contrast agent. Results: There were no differences in baseline demographics or clinical characteristics between the two groups. Although the total procedure time[(1.98±0.29) min vs.(2.11±0.14) min, P<0.04],length of fluoroscopic exposure [(1.83±0.30) vs.(1.98±0.14), P<0.19] and radiation dose in X-ray[(27.83±3.21) uGym2vs.(29.13±1.57) uGym2, P<0.30] were somewhat statistically different between groups, yet the difference was insignificant. No complications, including pericardial tamponade and aortic perforation, occurred in all patients. Conclusion: Iodine-free TSP under the guidance of Runthrough guidewire and fluoroscopy can be a simple, safe, economical and effective approach to TSP, and may be reproduced as a novel option for TSP in patients with contrast hypersensitivity or allergy-like reactions.
Ketone Body Rescued Seizure Behavior Of LRP1 Deficiency By Modulating Glutamate Transport
Authors: Zhang Jin-Ming , Chen Ming-Jie , He Jiong-Hui , Li Ya-Ping , Li Zhi-Cai , Ye Zi-Jing , Bao Yong-Hui , Huang Bing-Jun , Zhang Wen-Jie , Kwan Ping , Mao Yu-Ling , Qiao Jing-Da 
Published: January 2022

Abstract
LRP1, the low-density lipoprotein receptor 1, would be a novel candidate epilepsy gene according to our bioinformatic results and the animal study. In this study, we explored the role of LRP1 in Epilepsy and whether Beta-hydroxybutyrate, the principal ketone body of the ketogenic diet can treat epilepsy caused by LRP1 deficiency. UAS/GAL4 system was used to establish different genotype models. Flies were given Standard, High-sucrose, and ketone body food randomly. The bang-sensitive test was performed on flies and seizure-like behavior was assessed. Morphologic alteration of LRP1 defect in the brain was detected under GPF expression flies. We established global, astrocytic, and neuronal LRP1 knockdown flies. Whole body and glia LRP1 defect flies had a higher seizure rate compared to the control group in the behavior test. Ketone body decreased the seizure rate in behavior test in all LRP1 defect flies, compared to Standard and High sucrose diet. In morphologic experiments, we found that LRP1 deficiency caused partial loss of the ellipsoidal body and partial destruction of the fan-shaped body. Overexpression of glutamate transporter gene Eaat1 could mimic the ketone body effect on LRP1 deficiency flies. This study demonstrated that LRP1 defect globally or in astrocytes or neurons could induce epilepsy. The ketone body efficaciously rescued epilepsy caused by LRP1 knockdown. The results support screening for LRP1 mutations as discriminating conduct for individuals who require clinical attention and further clarify the mechanism of the ketogenic diet in Epilepsy, which could help Epilepsy patients making a precise treatment case by case.
Geometrical and Hemodynamic Variables for Thrombotic Risk Stratification in Kawasaki Disease
Authors: Yao Qiong , Peng Chen , Wang Sheng-zhang , Hu Xi-hong 
Published: January 2022

Abstract
Objectives
Thrombosis is a major adverse outcome for coronary artery aneurysms (CAA) in Kawasaki disease (KD). We investigated the geometric and hemodynamic abnormalities in patients with CAA and identified the risk factors for thrombosis by computational fluid dynamics (CFD) simulation.
Methods
We retrospectively studied 27 KD patients with 77 CAAs, including 20 CAAs with thrombosis in 12 patients. Patient-specific anatomic models obtained from cardiac magnetic resonance imaging (CMRI) were constructed to perform a CFD simulation. From the simulation results, we produced local hemodynamic parameters comprising of time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and relative resident time (RRT). The CAA’s maximum diameter (Dmax) and Z-score were measured on CMRI.
Results
Giant CAAs tended to present with more severe hemodynamic abnormalities. Thrombosed CAAs exhibited lower TAWSS (1.551 ± 1.535 vs. 4.235 ± 4.640dynes/cm2, p = 0.002), higher Dmax (10.905 ± 4.125 vs. 5.791 ± 2.826mm, p = 0.008), Z-score (28.301 ± 13.558 vs. 13.045 ± 8.394, p = 0.002), OSI (0.129 ± 0.132 vs. 0.046 ± 0.080, p = 0.01), and RRT (16.780 ± 11.982s vs. 9.123 ± 11.770s, p = 0.399) than the non-thrombosed group. An ROC analysis for thrombotic risk proved that all of the five parameters had area under the ROC curves (AUC) above 0.7, with Dmax delineating the highest AUC (AUCDmax = 0.871) and a 90% sensitivity, followed by Z-score (AUCZ−score = 0.849).
Conclusions
It is reasonable to combine the geometric index with hemodynamic information to establish a severity classification for KD cases.
Validation of the Modified Alvarado Score in Patients Attending A&amp;E Unit With Suspected Appendicitis – Prospective Clinical Study
Authors: Mán Eszter , Simonka Zsolt , Rárosi Ferenc , Pető Zoltán , Szilágyi András , Lázár György 
Published: January 2022

Abstract
BackgroundThe aim of our prospective study was to confirm the validity, diagnostic accuracy of the modified Alvarado score developed in the Department of Surgery, University of Szeged.Methods138 patients were enrolled in our study between 01 January 2019 and 01 January 2020. The patient’s modified Alvarado score was calculated in the Emergency Department before surgical consultation and decision of further therapy. The score was validated based on the final histology finding of the removed appendix. Additionally, potential correlation was examined between the frequency of drain usage, hospital stay, antibiotic use and the severity of the inflammation. ResultsComparing the scores with the histological findings, specificity of the modified Alvarado score was 84.78%, its sensitivity was 97.83% (with cutoff value of 5.5). Spearman's rank correlation (0.796) and ROC analysis (area under the curve 0.968) confirmed that the modified Alvarado score has an excellent predictive value in the diagnosis of acute appendicitis. Based on the result of the Fisher's exact test, cross tabulation and Spearman’s rank correlation correlation was found between the severity of the inflammation determined by the histology finding, the selected antibiotic and the duration of the antibiotic therapy, the average duration of hospitalization and drain insertion. ConclusionsBased on the results of our study, predictive value of the new, modified score system is excellent, using this score system is safe in the differential diagnosis of acute appendicitis as an aid for non-surgical consultants in emergency care. This new score system may decrease the number of unnecessary surgical consultations, decrease waiting time of the patients and some unnecessary examinations can be avoided. Trial RegistrationValidation of the modified Alvarado score in patients presenting in the Emergency Department with right lower abdominal complaints, ethical license number: 248/2018/SZTE, date of registration: 2018.11.04., name of ethics committee: SZTE SZAKK Regionális és Intézményi Humán Orvosbiológiai Kutatásetikai Bizottság- Clinical Research Coordination Office of the University of Szeged
Prediction of Retention Time and Collision Cross Section (CCSH+, CCSH- and CCSNa+) of emerging contaminants using Multiple Adaptive Regression Splines
Authors: Celma Alberto , Bade Richard , Sancho Juan V. , Hernández Félix , Humpries Melissa , Bijslma Lubertus 
Published: January 2022

Abstract
Ultra-high performance liquid chromatography coupled to ion mobility separation and high-resolution mass spectrometry instruments have proven very valuable for screening of emerging contaminants in the aquatic environment. However, when applying suspect or non-target approaches (i.e. when no reference standards are available) there is no information on retention time (RT) and collision cross section (CCS) values to facilitate identification. In-silico prediction tools of RT and CCS can therefore be of great utility to decrease the number of candidates to investigate. In this work, Multiple Adaptive Regression Splines (MARS) was evaluated for the prediction of both RT and CCS. MARS prediction models were developed and validated using a database of 477 protonated molecules, 169 deprotonated molecules and 249 sodium adducts. Multivariate and univariate models were evaluated showing a better fit for univariate models to the empirical data. The RT model (R2=0.855) showed a deviation between predicted and empirical data of ± 2.32 min (95% confidence intervals). The deviation observed for CCS data of protonated molecules using CCSH model (R2=0.966) was ± 4.05% with 95% confidence intervals. The CCSH model was also tested for the prediction of deprotonated molecules resulting in deviations below ± 5.86% for the 95% of the cases. Finally, a third model was developed for sodium adducts (CCSNa, R2=0.954) with deviation below ± 5.25% for the 95% of the cases. The developed models have been incorporated in an open access and user-friendly online platform which represents a great advantage for third-party research laboratories for predicting both RT and CCS data.
Design of a Novel Integrated Ultrasonic Tool Holder for Friction Stir Welding
Authors: Ju Jianzhong , Long Zhili , Ye Shuyuan , Liu Yongzhi , Zhao Heng 
Published: January 2022

Abstract
Ultrasonic vibration used in friction stir welding (FSW) has shown advantages in reducing welding defects and improving welding quality. How to design an ultrasonic tool holder is a challenge because the holder is rotating in a confined space. In this study, we design a 20 kHz integrated ultrasonic tool holder in FSW. This novel configuration can be applied in general machining equipment. The elastic modulus is measured by non-destructive acoustic testing to attain the precise frequency. Three FSW transducers with alloy steel are designed by the modal analysis and the transducer prototypes are fabricated. The effect of pre-tightening force on transducer frequency is investigated, where the prestress of the piezoelectric stack instead of the torque is tested to achieve an optimal working frequency. The vibration of the transducers is measured by a Doppler Vibrometer System. It proved that the resonant frequencies are well consistent between simulation model and the experiment by the elastic modulus testing and the pre-tightening optimization. Moreover, the experiment demonstrates that the vibration amplitude is significantly different, even in a slight difference of steel material properties are adopted. The dynamic performance of the designed transducers is acceptable by the vibration measurement.
Semilinear Transformations in Coding Theory: A New Technique in Code-Based Cryptography
Authors: Guo Wenshuo , Fu Fang-Wei 
Published: January 2022

Abstract
This paper presents a new technique for disturbing the algebraic structure of linear codes in code-based cryptography. Specifically, we introduce the so-called semilinear transformations in coding theory and then apply them to the construction of code-based cryptosystems. Note that Fqm can be viewed as an Fq -linear space of dimension m , a semilinear transformation φ is therefore defined as an Fq -linear automorphism of Fqm . Then we impose this transformation to a linear code C over Fqm . It is clear that φ (C) forms an Fq -linear space, but generally does not preserve the Fqm -linearity any longer. Inspired by this observation, a new technique for masking the structure of linear codes is developed in this paper. Meanwhile, we endow the underlying Gabidulin code with the so-called partial cyclic structure to reduce the public-key size. Compared to some other code-based cryptosystems, our proposal admits a much more compact representation of public keys. For instance, 2592 bytes are enough to achieve the security of 256 bits, almost 403 times smaller than that of Classic McEliece entering the third round of the NIST PQC project.
A Brief Overview of Road Accidents and Recent Preventive Methodologies for Accident Hotspots in the United Arab Emirates
Authors: Ali Ijaz 
Published: January 2022

Abstract
This paper highlights major causes of road accidents in the United Arab Emirates (UAE) and explores the possibility of reducing them through modern in-vehicle control technologies. Mostly, road safety data from the Global Road Safety Facility (GSRF), Road Safety Polices and Regulations for UK and UAE have been reviewed for comparison and analysis. It contains a descriptive analysis of road accident data which was taken from Ministry of Interior (MOI) - UAE website. It shows how the Pareto Principle applies to most of the road accidents in the UAE with young males’ poor driving habits and higher maximum speed limits being the major causes and, a systematic approach as per the Nilsson Power Model, to tackle these issues. It ends with the conclusion that, although high speed limits on urban roads and highways are some of the critical factors in causing dangerous road accidents but, it can be tackled with by implementing strict road safety policies and enforcing them with modern in vehicle technologies.