bluuebunny/crossref_metadata_2025_split huggingface dataset:
Control of flow separation over a wing model with plasma synthetic jets
Authors: SU Zhi , SONG Guozheng , ZONG Haohua , LIANG Hua , LI Jun , XIE Like , LIU Xuecheng , KONG Weiliang 
Published: February 2022

AbstractAn array of 30 plasma synthetic jet actuators (PSJAs) is deployed using a modified multichannel discharge circuit to suppress the flow separation over a straight-wing model. The lift and drag of the wing model are measured by a force balance, and the velocity fields over the suction surface are captured by a particle imaging velocimetry system. Results show that the flow separation of the straight wing originates from the middle of the model and expands towards the wingtips as the angle of attack increases. The flow separation can be suppressed effectively by the PSJAs array. The best flow control effect is achieved at a dimensionless discharge frequency ofF+= 1, with the peak lift coefficient increased by 10.5% and the stall angle postponed by 2°. To further optimize the power consumption of the PSJAs, the influence of the density of PSJAs on the flow control effect is investigated. A threshold of the density exits (with the spanwise spacing of PSJAs being 0.2 times of the chord length in the current research), below which the flow control effect starts to deteriorate remarkably. In addition, for comparison purposes, a dielectric barrier discharge (DBD) plasma actuator is installed at the same location of the PSJAs. At the same power consumption, 4.9% increase of the peak lift coefficient is achieved by DBD, while that achieved by PSJAs reaches 5.6%.
Characteristics of water volatilization and oxides generation by using positive and negative corona
Authors: CHEN Ke , WAN Lianghao , CHEN Bingyan , CHU Tao , GENG Renyue , SONG Deyu , HE Xiang , SU Wei , YIN Cheng , SHAN Minglei , JIANG Yongfeng 
Published: February 2022

Abstract
The physical and chemical properties have significant differences for the positive and negative charged particles generated by discharge. In this work, a positive and negative corona discharge system was established, and two discharge reactors for charged particles restraining and acting were designed by a needle electrode covered with a quartz tube and a plate electrode filled with water. The corona discharges happened within the needle-plate electrodes were excited by a positive and negative high voltage source, and the characteristics of both water volatilization and oxides generation were examined within influence of the distances of both quartz tube inside and outside. The results show that the characteristics of both the water volatilization and oxides generation can be affected by the distances of both quartz tube inside and outside. When the distances of tube inside were increased from 5.00 to 13.00 mm, the water volatilizations decreased under negative corona, and increased firstly and declined immediately under positive corona. The maximum value of the water volatilization appeared in the distances of tube inside with 6.00–8.00 mm. In addition, the concentrations of the HNO
x
and H2O2 in treated water decreased with increasing the distances of tube inside. Moreover, with increasing the distances of tube outside from 4.00 to 14.00 mm, the change trends of both the water volatilizations and oxides presented the same as the distances of tube inside, and the maximum value of the water volatilization and oxides appeared in the distance of tube outside with about 9.00 mm. Overall, the positive corona can generate more water volatilizations and oxides in water than negative corona, and non H2O2 can be produced by negative corona. The results reflect the difference between positive and negative corona interaction with water, which can provide reference for plasma application.
Relationship of mode transitions and standing waves in helicon plasmas
Authors: WU Mingyang , XIAO Chijie , WANG Xiaogang , LIU Yue , XU Min , TAN Chang , XU Tianchao , YU Xiuming , HE Renchuan , XU Andong 
Published: February 2022

Abstract
Helicon wave plasma sources have the well-known advantages of high efficiency and high plasma density, with broad applications in many areas. The crucial mechanism lies with mode transitions, which has been an outstanding issue for years. We have built a fluid simulation model and further developed the Peking University Helicon Discharge code. The mode transitions, also known as density jumps, of a single-loop antenna discharge are reproduced in simulations for the first time. It is found that large-amplitude standing helicon waves (SHWs) are responsible for the mode transitions, similar to those of a resonant cavity for laser generation. This paper intends to give a complete and quantitative SHW resonance theory to explain the relationship of the mode transitions and the SHWs. The SHW resonance theory reasonably explains several key questions in helicon plasmas, such as mode transition and efficient power absorption, and helps to improve future plasma generation methods.
Designing a System of Contractual Liability: Jacques Cujas Inspired by Roman Law
Authors: Kordasiewicz Stanisław 
Published: February 2022

Abstract
Jacques Cujas is one of the most respected and esteemed jurists in Western legal tradition. According to prevailing views, he was primarily focused on the interpretation of Roman law. However, this perception does not take fully into account the diversity of his contributions. Preliminary results arising from this research article indicate that under the veil of the reconstruction of ancient Roman law, Cujas presented new ideas and challenged traditional ways of approaching risk and liability. His innovative interpretation of a crucial classical text about liability rules was not limited to historical explanations of Roman law, but instead was intended to find practical solutions. The result was the first coherent liability system based on an improved reading of the Digest. This pilot study focuses on the process of designing a system of contractual liability. The research is based on the analysis of Cujas’s creative interpretation of a cornerstone text about Roman liability rules. It shows how recourse to the humanist method led to a profound change in the interpretation of fundamental legal concepts. In his commentary on classical liability standards (D.50.17.23), Cujas added several contracts that were unknown to Roman law (eg the contract of divorce). Moreover, he held that a group of four legal relationships (mandate, managing of others’ affairs, loan for use, and guardianship) should include an extremely high standard of liability. The author also redefined remaining liability criteria and allocated them to particular contracts. Thus the study argues that one of the most respected members of the historical school of French legal humanism was at the same time an ingenious liability system designer. Further research will determine if and how consistently Cujas applied this system throughout his work.
Service Users’ Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists?
Authors: Dhital Ranjita , Coleman Rachel , Day Ed , Drummond Colin , Lingford-Hughes Anne , Marsden John , Phillips Tom , Sinclair Julia , Strang John , Weinman John , Whittlesea Cate , Widyaratna Kideshini , Donoghue Kim 
Published: February 2022

Abstract

Aims
To understand service users' views and experiences of alcohol relapse prevention medication, views of a telephone behavioural modification intervention delivered by pharmacists and the use of Contingency Management (CM) to support acamprosate adherence following assisted alcohol withdrawal.

Methods
Four focus groups were conducted within four alcohol treatment and recovery groups across England (UK), with service users with lived experience of alcohol dependence (26 participants). Semi-structured topic guide was used to explore participants' views and experiences of alcohol relapse prevention medication, a telephone behavioural modification medication intervention delivered by pharmacists, and the use of CM to support acamprosate adherence. These were audio-recorded, transcribed verbatim and thematically analysed inductively and deductively.

Results
Four themes were identified: concerns about support and availability of alcohol relapse prevention medication; lack of knowledge and understanding about acamprosate treatment; positive perceptions of acamprosate adherence telephone support from pharmacists; and negative perceptions of CM to support acamprosate adherence. There were misunderstandings about acamprosate's mode of action and strong negative beliefs about CM. However, most were positive about pharmacists' new role to support acamprosate adherence.

Conclusion
This study highlighted challenges service users face to commence alcohol relapse prevention medication. It appears service users could benefit from a pharmacist-led telephone intervention to improve understanding about acamprosate medication, particularly, if delivered in an engaging and motivating way.
A Single-Center Pilot Study to Classify Signs of Dorsal Hand Aging Using 3 Grading Scales
Authors: Wamsley Christine E , Vingan Nicole , Barillas Jennifer , Culver Abby , Turer David M , Kenkel Jeffrey M 
Published: February 2022

Abstract

Background
While validated scales must be created in order to systemically evaluate patients and quantify outcomes of aesthetic hand treatments, scales currently available are limited to the analysis of volume loss alone.

Objectives
The purpose of this study was to develop 3 validated scales for the assessment of dorsal hand aging that also take into consideration wrinkling and pigmentation.

Methods
Fifty (50) healthy volunteers (40 females and 10 males) with Fitzpatrick skin types I-IV were recruited, and standard photographs of their left and right dorsal hands were taken with a Nikon D7100 (Nikon; Minato, Tokyo, Japan) camera. Using 25 randomized photographs, 11 plastic surgery physicians (3 chief residents, 6 senior residents, and 2 aesthetic surgery fellows) were trained on the 3 scales under investigation as well as the already-validated Merz Hand Grading Scale (MHGS). The evaluators then viewed the remaining 75 photographs independently and assigned a grade for each of the 4 scales to each photograph. Inter-rater variability was calculated for each scale.

Results
The Kappa score for the MHGS was 0.25, indicating fair agreement; 0.40 for wrinkle scale, indicating fair agreement; and 0.48 and 0.46 for the pigmentation density and intensity scales, respectively, indicating moderate agreement (P &lt; 0.001).

Conclusions
The results show that after receiving training, the inter-rater agreement for the 3 scales under investigation was similar or slightly higher than that for the MHGS. These 3 photographic classification systems can be used consistently and reliably to characterize multiple signs of dorsal hand aging.

Level of Evidence: 2
Refining Reproduction Number Estimates to Account for Unobserved Generations of Infection in Emerging Epidemics
Authors: Brizzi Andrea , O’Driscoll Megan , Dorigatti Ilaria 
Published: February 2022

Abstract

Background
Estimating the transmissibility of infectious diseases is key to inform situational awareness and for response planning. Several methods tend to overestimate the basic (R0) and effective (Rt) reproduction numbers during the initial phases of an epidemic. In this work we explore the impact of incomplete observations and underreporting of the first generations of infections during the initial epidemic phase.

Methods
We propose a debiasing procedure that utilizes a linear exponential growth model to infer unobserved initial generations of infections and apply it to EpiEstim. We assess the performance of our adjustment using simulated data, considering different levels of transmissibility and reporting rates. We also apply the proposed correction to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incidence data reported in Italy, Sweden, the United Kingdom, and the United States.

Results
In all simulation scenarios, our adjustment outperforms the original EpiEstim method. The proposed correction reduces the systematic bias, and the quantification of uncertainty is more precise, as better coverage of the true R0 values is achieved with tighter credible intervals. When applied to real-world data, the proposed adjustment produces basic reproduction number estimates that closely match the estimates obtained in other studies while making use of a minimal amount of data.

Conclusions
The proposed adjustment refines the reproduction number estimates obtained with the current EpiEstim implementation by producing improved, more precise estimates earlier than with the original method. This has relevant public health implications.
Language Use and Identity in Minority Hungarian and Hungarian–Romanian Deaf Families
Authors: Belenyi Emese , Flora Gavril 
Published: February 2022

Abstract
This paper discusses language use and identity patterns in families set up by deaf partners living in Romania, where at least one of the spouses belongs to the ethnic Hungarian minority. Language use and transmission of identity to children in ethnically homogenous (Hungarian) or heterogeneous (Hungarian–Romanian) families of deaf are explored. The research is based on a survey conducted among members of the ethnic Hungarian Deaf community (including ethnic Romanian spouses), life-path interviews with selected deaf persons and interviews with special school educators. The research results denote that in the case of deaf people living in ethnically homogeneous marriages who graduated from Hungarian language special school the transmission of Hungarian identity, Hungarian sign language/oral language knowledge—combined with the components of Deaf culture—tends to be a natural and usually undisturbed process. However, if one of the spouses is Romanian, the language of communication within the family will probably be the Romanian sign language/oral language. On the other hand, in the families where ethnic minority and ethnic majority family members are present, with typical and atypical hearing, complex, multifaceted linguistic communication models might prevail, favoring specific multicultural modes of intrafamilial identity development and transmission.
The value and limitations of new oral anticoagulant plasma level assessments
Authors: Van der Linden Lorenz , Hias Julie , Vanassche Thomas 
Published: February 2022

abstract
The class of new oral anticoagulants (NOACs) has been developed to provide reliable oral anticoagulation without the need for therapeutic drug monitoring. Based on phase I and II trials and pharmacokinetic and pharmacodynamic modeling, fixed drug doses have been selected for large phase III clinical trials for each currently available NOAC. In these trials, the use of the fixed dose without plasma level assessments was shown to be at least as effective and at least as safe as vitamin K antagonists with continuous therapeutic drug monitoring. Real world evidence reaffirms that the use of a fixed NOAC dose without plasma level assessment is safe and effective in a large variety of patients. Nevertheless, measurement of NOAC plasma levels can add information that may be useful in some clinical scenarios. This review discusses the possible use cases, the limitations, and the practical implementation of measuring NOAC plasma concentrations.
Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans
Authors: Ike Yasuaki , Tomioka Masahiro , Iino Yuichi 
Published: February 2022

Abstract
The ubiquitin-proteasome system is associated with various phenomena including learning and memory. In this study, we report that E3 ubiquitin ligase homologs and proteasome function are involved in taste avoidance learning, a type of associative learning between starvation and salt concentrations, in Caenorhabditis elegans. Pharmacological inhibition of proteasome function using bortezomib causes severe defects in taste avoidance learning. Among 9 HECT-type ubiquitin ligase genes, loss-of-function mutations of 6 ubiquitin ligase genes cause significant abnormalities in taste avoidance learning. Double mutations of those genes cause lethality or enhanced defects in taste avoidance learning, suggesting that the HECT-type ubiquitin ligases act in multiple pathways in the processes of learning. Furthermore, mutations of the ubiquitin ligase genes cause additive effects on taste avoidance learning defects of the insulin-like signaling mutants. Our findings unveil the consequences of aberrant functions of the proteasome and ubiquitin systems in learning behavior of Caenorhabditis elegans.
RNA-sequencing Reveals a Gene Expression Signature in Skeletal Muscle of a Mouse Model of Age-associated Postoperative Functional Decline
Authors: Asche-Godin Samantha L , Graham Zachary A , Israel Adina , Harlow Lauren M , Huang Weihua , Wang Zhiying , Brotto Marco , Mobbs Charles , Cardozo Christopher P , Ko Fred C 
Published: February 2022

Abstract
This study aimed to characterize the effects of laparotomy on postoperative physical function and skeletal muscle gene expression in male C57BL/6N mice at 3, 20, and 24 months of age to investigate late-life vulnerability and resiliency to acute surgical stress. Pre and postoperative physical functioning was assessed by forelimb grip strength on postoperative day (POD) 1 and 3 and motor coordination on POD 2 and 4. Laparotomy-induced an age-associated postoperative decline in forelimb grip strength that was the greatest in the oldest mice. While motor coordination declined with increasing age at baseline, it was unaffected by laparotomy. Baseline physical function as stratified by motor coordination performance (low functioning vs high functioning) in 24-month-old mice did not differentially affect postlaparotomy reduction in grip strength. RNA sequencing of soleus muscles showed that laparotomy-induced age-associated differential gene expression and canonical pathway activation with the greatest effects in the youngest mice. Examples of such age-associated, metabolically important pathways that were only activated in the youngest mice after laparotomy included oxidative phosphorylation and NRF2-mediated oxidative stress response. Analysis of lipid mediators in serum and gastrocnemius muscle showed alterations in profiles during aging and confirmed an association between such changes and functional status in gastrocnemius muscle. These findings demonstrate a mouse model of laparotomy which recapitulated some features of postoperative skeletal muscle decline in older adults, and identified age-associated, laparotomy-induced molecular signatures in skeletal muscles. Future research can build upon this model to study molecular mechanisms of late-life vulnerability and resiliency to acute surgical stress.
Experimental investigation of hot water cogeneration using a carbonizer fit out with a preheating system
Authors: Kpelou Pali , Kongnine Damgou Mani , Asse Roger , Mouzou Essowè 
Published: February 2022

Abstract
Carbonization is a thermochemical process that generates thermal energy and charcoal. The system allowing to recover the heat energy for co-, tri- and multi-generation is currently more investigated. The use of multi-generation systems is beneficial from the standpoint of increasing the usage of biomass, energy efficiency and reducing the impact on forests.
The aim of this article was to design a carbonizer fit out with a thermal insulation layer and use it for the carbonization of some local biomasses, namely wood chips and teak wood. A heat recovery system was then incorporated into the carbonizer to cogenerate hot water from the thermal energy induced by the carbonization process. The results obtained with the designed carbonizer were 20% and 26% in mass yield respectively for teck wood and wood chips. The system developed that heat recovery was able to generate 25 L/h hot water at 45°C and 50°C during the first and the last phases respectively for wood chips and teak wood carbonization. The introduction of the preheating system induced a significant rise of the water’s temperature. The highest maximum value of the hot water temperature was 62°C obtained during the carbonization of both studied fuels.
Vicarious Interactions in Online Support Communities: The Roles of Visual Anonymity and Social Identification
Authors: Dai Yue (Nancy) , Shi Jingyuan 
Published: February 2022

Abstract
Online information seekers often do not actively post or engage in interactions with others, inviting research on how passive users of online communities benefit from the information they see. Based on the social identity model of deindividuation effects model (SIDE) and social identity theory, we proposed and tested the idea that observers of a supportive interaction online could relate to the observed support seeker based on their shared gender and, in turn, become vicariously influenced by the support provider’s message to the support seeker. An experiment using a sample of young adults (N = 326) in the United States provided support to the proposition. Furthermore, the outcomes of the vicarious interaction were qualified by the genders of the observed interactants and enhanced by the lack of profile photos. The findings advance the understandings of vicarious interaction in online context and guide the design of online communities to promote mental well-being.
Lay Summary
Ample evidence shows that people benefit tremendously from participating in online health support communities, but less is understood about how people who do not actively participate in interactions benefit from these communities. We conducted an online experiment using a sample of young adults in the United States. The results showed that females, compared with males, are more likely to be persuaded to seek professional counseling for mental health issues from observing a supportive conversation online. The persuasive effect of reading supportive interactions was enhanced when female participants shared the same gender with the observed support seeker and when the observed interactants had no profile photos.
An efficient IoT forensic approach for the evidence acquisition and analysis based on network link
Authors: Khalid Alabdulsalam Saad , Duong Trung Q , Raymond Choo Kim-Kwang , Le-Khac Nhien-An 
Published: February 2022

Abstract
In an Internet of Things (IoT) environment, IoT devices are typically connected through different network media types such as mobile, wireless and wired networks. Due to the pervasive nature of such devices, they are a potential evidence source in both civil litigation and criminal investigations. It is, however, challenging to identify and acquire forensic artefacts from a broad range of devices, which have varying storage and communication capabilities. Hence, in this paper, we first propose an IoT network architecture for the forensic purpose that uses machine learning algorithms to autonomously detect IoT devices. Then we posit the importance of focusing on the links between different IoT devices (e.g. whether one device is controlled or can be accessed from another device in the system), and design an approach to do so. Specifically, our approach adopts a graph for modelling IoT communications’ message flows to facilitate the identification of correlated network traffic based on the direction of the network and the associated attributes. To demonstrate how such an approach can be deployed in practice, we provide a proof of concept using two IoT controllers to generate 480 commands for controlling two IoT devices in a smart home environment and achieve an accuracy rate of 98.3% for detecting the links between devices. We also evaluate the proposed autonomous discovering of IoT devices and their activities in a TCP network by using real-world measurements from a public dataset of a popular off-the-shelf smart home deployed in two different locations. We selected 39 out of 81 different IoT devices for this evaluation.