bluuebunny/crossref_metadata_2025_split huggingface dataset:
circ_0085296 inhibits the biological functions of trophoblast cells to promote the progression of preeclampsia via the miR-942-5p/THBS2 network
Authors: Liu Jiyi , Yang Yan , Liu Wenlan , Lan Ruilun 
Published: March 2022

Abstract
Insufficient invasion of trophoblast cells is one of the important causes of preeclampsia (PE). Circular RNA (circRNA) has been proven to regulate the biological functions of trophoblast cells and mediate the progression of PE. The expression of circ_0085296, microRNA (miR)-942-5p, and thrombospondin 2 (THBS2) was detected by quantitative real-time PCR. In addition, the interaction between miR-942-5p and circ_0085296 or THBS2 was confirmed by dual-luciferase reporter assay and RIP assay. Our data showed that circ_0085296 was upregulated in the placental tissues of PE patients. Silenced circ_0085296 could enhance the proliferation, migration, invasion, and angiogenesis of HTR-8/SVneo cells. Besides, circ_0085296 was found to act as miR-942-5p sponge. Function analysis results suggested that miR-942-5p inhibitor reversed the positive regulation of circ_0085296 knockdown on the biological functions of HTR-8/SVneo cells. Moreover, THBS2 was a target of miR-942-5p, and its overexpression also reversed the promotion effect of miR-942-5p on the proliferation, migration, invasion, and angiogenesis of HTR-8/SVneo cells. Also, circ_0085296 was discovered to positively regulate THBS2 by sponging miR-942-5p. To sum up, our results revealed that circ_0085296 could inhibit trophoblast cells proliferation, migration, invasion, and angiogenesis by regulating miR-942-5p/THBS2, confirming that circ_0085296 might be a potential therapeutic target for PE.
Interleukin-35 in autoimmune dermatoses: Current concepts
Authors: Xie Yuming , Zhang Huilin , Huang Junke , Zhang Qing 
Published: March 2022

AbstractInterleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregulatory functions of T cells, B cells, macrophages, and other immune cell types. Although there is currently limited research on the roles of IL-35 in human autoimmunity, many studies have demonstrated that IL-35 may mediate immunosuppression. Therefore, it plays an essential role in some autoimmune dermatoses, including systemic lupus erythematosus, psoriasis, systemic sclerosis, and dermatomyositis. We will introduce the structure and biological characteristics of IL-35 and summarize its effects on the occurrence and development of autoimmune dermatoses in this article. It is suggested that IL-35 is a possible target for therapy in the aforementioned diseases.
“Adverbs and functional heads” twenty years later: cartographic methodology, verb raising and macro/micro-variation
Authors: Tescari Neto Aquiles 
Published: March 2022

AbstractAdverbs and Functional Heads: a Cross-Linguistic perspective(Cinque, Guglielmo. 1999.Adverbs and functional heads: A cross-linguistic perspective. New York & Oxford: Oxford University Press)—one of the founding works of “Syntactic Cartography”—combines some of the developments in Syntactic Theory from the 1980s and 1990s with insightful contributions from Linguistic Typology. This paper has two interrelated goals. First, it aims to review the fundamental theses of Cinque’s monography of 1999—which are far from controversial among scholars working in Cartography—; at the same time it provides conceptual support to them. Secondly, it aims to explore some methodological tools of Syntactic Cartography presented and discussed by Cinque, Guglielmo. 1999.Adverbs and functional heads: A cross-linguistic perspective. New York & Oxford: Oxford University Press, namely the so-calledprecedence-and-transitivity tests—after a brief discussion on methodology used to recognise the functional categories, namely the criterion by Jackendoff, Ray. 1972.Semantic interpretation in generative grammar. Cambridge, MA: MIT Press—and the use of the hierarchies as tools to detect intra and interlinguistic variation. With regard to this latter issue, the paper gathers data from Brazilian Portuguese, Canadian English and Colombian Spanish on verb raising. The discussion of the data not only favours Cinque, Guglielmo. 2017. On the status of functional categories (heads and phrases).Language and Linguistics18(4). 521–576 recent updates of his theoretical approach to the cartography of the clause but also shows how Cartography offers a natural scenario for a methodological approach to both micro and macro-variation.
Las oraciones de relativo predicativas en español: pronombres reasuntivos y variación dialectal
Authors: Agulló Jorge 
Published: March 2022

AbstractPredicative or pronominal relative clauses in Spanish take a pronominal category as their head. These configurations show some grammatical traits and a geographical variation which have not yet been inquiried into. These structures, as it is argued in this paper, may host two different types of resumptive pronouns: what will be called asymmetric resumption, triggered by subject-object asymmetries; and resumption as a case-matching mechanism, available in non-matching semi-free relative clauses. As for the head of the construction, dialects of Peninsular Spanish are grouped into those which resort to the explicit pronoun and those which show a propensity to use the implicit pronominal category. The variant headed by the implicit pronoun is similar in some respects to relative clause extraposition, but some new data are brought to the fore that distinguish one construction from the other.
Suha György: Bevezetés a szangó nyelvbe. Magyar-szangó szójegyzékkel
Authors: A. Gergely András 
Published: March 2022

A. Gergely András a következő művet mutatta be:
Suha György: Bevezetés a szangó nyelvbe. Magyar-szangó szójegyzékkel. Publikon Kiadó, Pécs – Budapest, 2020., 129 oldal
„Emlékeink tárháza”
Authors: Batalka Krisztina 
Published: March 2022

A tanulmány a Budapesti Műszaki és Gazdaságtudományi Egyetem Levéltárában található fotógyűjteményt mutatja be. Részletesen kitér a fotóállomány összetételére, a fényképek készítésének céljaira, valamint az egyetemi és a magánforrásból származó fényképek leírásának és feldolgozásának nehézségeire. Ismerteti a fotók további gyűjtésével és (online) közzétételével kapcsolatos szempontokat, hangsúlyozva a topotékák mint közösségi építésű helytörténeti fotógyűjtemények szerepét. Az írás felvillantja, hogy a fotók vizuális forrásként hogyan tudnak hasznosulni az egyetemtörténet-írással foglalkozók vagy más kutatási területeket művelők, illetve az egyetem és polgárai számára.
Fotó: Budapesti Műszaki és Gazdaságtudományi Egyetem Levéltár
Fényképek a művészeti képzés hátterében
Authors: Peternák Miklós 
Published: March 2022

Az MKE fényképgyűjteménye a szó szoros értelmében lappangó anyag volt közel száz éven át, mivel a 19. századi, főként műtárgyreprodukciókból álló fényképek a technika változásával kikerültek a napi használatból. Az 1990-es évek legelején figyelt fel a könyvtár akkori igazgatója, B. Majkó Katalin erre a kivételes corpusra, s szorgalmazta szakszerű feldolgozását, mely lényegében még ma is tart. 2016-ban és 2018-ban az egyetem két kiállítás és egy könyv formájában mutatta be a közönség számára ezt a nemzetközi szempontból is jelentős képanyagot. E munka során számos korábban ismeretlen történet is feltárult az idén 150 éves intézmény múltjából, melyekből néhányat mutat be az itt közölt dolgozat.
Fotó: Magyar Képzőművészeti Egyetem fotógyűjtemény
A typology of proportional quantifiers: Evidence from Polish partitives
Authors: Wągiel Marcin 
Published: March 2022

AbstractIn this paper, I investigate the distribution and semantic behavior of various proportional quantifiers (PQs) in Polish. Based on novel evidence including corpus data, I conclude that Polish PQs do not constitute a uniform category, but rather can be divided into four distinct classes based on the following properties: i) (in)compatibility with numerals and measure words, ii) (in)compatibility with approximative modifiers, iii) (in)compatibility with cumulative predicates and iv) (non)occurrence of spatial integrity effects. I propose that such a typology results from an interplay between more primitive semantic notions. In particular, the data call for combining degree semantics with a mereotopological approach to the meaning of PQs.
Formação continuada de professores e a teoria histórico-cultural: uma análise bibliográfica
Authors: Brazier Fabio , Rocha Maria Silvia Pinto de Moura Librandi da 
Published: March 2022

Este estudo busca identificar o que revelam as pesquisas realizadas no período entre 2000 a 2018, sobre a formação continuada de professores, com fundamentação teórica na abordagem histórico-cultural. Para alcançar esse objetivo foi feita pesquisa bibliográfica parametrizada na Biblioteca Digital de Teses e Dissertações (BDTD). Por meio do levantamento realizado foi possível mapear tendências de apropriações teóricas no campo da formação de professores, identificando elementos que caracterizem os processos formativos adotados, quais as temáticas abordadas, segmentos pesquisados e os principais conceitos teóricos utilizados para tratar a questão formativa. A análise aponta para a presença de ações formativas baseadas na abordagem histórico-cultural, com predominância de estudos envolvendo práticas pedagógicas, no segmento do Ensino Fundamental. No entanto, essas ainda necessitam de uma elaboração teórica mais adensada especificando os conceitos teóricos assumidos, bem como a compreensão do desenvolvimento humano como processo histórico, cultural e social.
QUANDO A ESCOLA PÚBLICA PRESTA SOCORRO AOS BOMBEIROS: A PESQUISA E A EXTENSÃO EM PROL DA COMUNIDADE LOCAL
Authors: Gonino Gabriel Murilo Ribeiro , Stahnke Eduardo 
Published: March 2022

O presente trabalho visou defender o espírito colaborativo que deve estar presente em ações que envolvem a escola pública e a sociedade, em que o fortalecimento do protagonismo técnico-científico de estudantes da educação básica por meio de pesquisa e extensão será cada vez mais desejável em prováveis tempos de negacionismo. No contexto do presente trabalho, percebe-se que as corporações de bombeiros voluntários são associações sem fins lucrativos que geralmente necessitam de parcerias público-privadas para se manter. No entanto, é comum que passem por dificuldades financeiras que afetam sua finalidade primeira de salvar vidas e patrimônio material. Uma corporação de bombeiros voluntários de uma pequena cidade do interior do estado de Santa Catarina pediu socorro a uma escola pública, e esta esteve pronta a atender quem tanto nos acode, dando início ao trabalho aqui apresentado. É oneroso manter um sistema digital comercial para gerenciar uma corporação. Pensando na autonomia financeira da corporação parceira e no protagonismo transformador dos estudantes, iniciamos o desenvolvimento de um sistema gratuito que serviu de pano de fundo para esta ação dialógica.
Knowledge, Attitude and Clinical Practice of Dentists about Extraction of First Permanent Molars
Authors: Demir Pınar , Aydoğdu Hatice , SarI Şaziye 
Published: March 2022

Purpose: The extraction of permanent first molar (PFM) teeth with poor prognosis allows the build of a new-and-ideal occlusion with the spontaneous movement of the healthy second and third molars by taking advantage of the patient’s development. This study aimed to evaluate dentists’ knowledge level about controlled tooth extractions and determine their information needs.
Study design: The survey, consisting of 9 questions about balance and compensation extractions, was prepared on Google Forms and sent via email to dentists.
Results: The questionnaire was sent to 3137 dentists and 472 (15.04%) of them answered. While deciding on PFM extraction, the rate of those who checked the presence of permanent 3rd molar tooth was found to be 64.4%. Although 79% of pedodontists stated that they knew about balance extractions, only 60.9% of them apply it in the clinic. After maxillary PFM extraction, the rate of oral and maxillofacial surgeons who think that “mandibular PFM over-erupt” was 92.8%, and the rate of orthodontists was 68.7%. 87.1% of the participants stated that they needed more information about controlled extractions.
Clinical Significance: It is possible to raise awareness, encourage the common and follow-up of correct clinical practices, and avoid complications; by adding controlled extractions to the undergraduate education program.
JUVENTUDE, SUSTENTABILIDADE E CAPITALISMO VERDE <br/><br/>YOUTH, SUSTAINABILITY AND GREEN CAPITALISM
Authors: Barros Antonio Teixeira de 
Published: March 2022

O artigo tem como objetivo analisar as percepções da juventude brasileira sobre o capitalismo verde, suas práticas e discursos, baseado em questionário eletrônico com 1.225 jovens. O questionário indaga sobre o que os jovens entendem por capitalismo verde, como percebem o papel do Estado, do mercado e da sociedade e também sobre as práticas de consumo verde. O suporte teórico utiliza contribuições da sociologia ambiental, da sociologia da juventude e da sociologia do consumo. As principais conclusões indicam que jovens apresentam um elevado nível de conhecimento sobre sustentabilidade ambiental, com várias ações práticas já incorporadas individualmente e pelas suas famílias. Os informantes compreendem que o êxito da sustentabilidade ambiental e do consumo verde depende de uma articulação entre Estado, mercado e sociedade. Em suma, os dados mostram como os jovens são agentes desse novo processo civilizador, representado pela ambientalização das práticas e das relações de consumo.AbstractThe article aims to analyze the perceptions of Brazilian youth about green capitalism, its practices and speeches, based on websurvey with 1,225 young people. The survey inquires about what young people mean by green capitalism, how they perceive the role of the State, the Market and Society and also the practices of green consumption. The theoretical support uses contributions from environmental sociology and the sociology of youth. The main conclusions indicate that young people present a high level of knowledge aboutenvironmental sustainability, with several practical actions already incorporated individually and by their families. The informants understand that the success ofenvironmental sustainability and green consumption depends on a link betweenState, market and society. In sum, the data show how young people are agents of this new civilizing process, represented by the environmentalization of practices and social relations.
Conseguenze della COVID-19 e delle misure di lockdown tra le persone che vivono con HIV in Italia.
Authors: Ranzani Alice , al. et 
Published: March 2022

È stata realizzata un’intervista per indagare le conseguenze della COVID-19 sui pazienti HIV-positivi durante la prima ondata pandemica. L’intervista è stata realizzata presso l’ambulatorio di Malattie Infettive dell’Ospedale San Gerardo di Monza tra maggio e settembre 2020. I pazienti sono stati sottoposti ad un’intervista che includeva domande sull’impatto di COVID-19 dal punto di vista personale, economico e dell’accesso alle cure. Abbiamo inoltre indagato la presenza di fattori di rischio che favorivano l’interruzione della ART e un rebound della carica virale. Sono stati intervistati 243 pazienti (76.5% uomini, 81% Italiani, 27.1% MSM, 21.4% >60 anni). Quattro (1.6%) avevano ricevuto una diagnosi di COVID-19 con conferma microbiologica, 18 (7.4%) avevano manifestato sintomi compatibili ma non avevano effettuato tampone nasofaringeo. Tredici avevano perso un familiare a causa di COVID-19; 1 su 5 riferiva importanti perdite economiche e 1 su 4 stress psicologico. Due terzi dei pazienti avevano dovuto posporre le visite di controllo per l’infezione da HIV e 21 riferivano problematiche di salute che non era stato possibile gestire durante il periodo di lockdown. Ventidue pazienti hanno riferito un’aderenza subottimale alla ART e per 6 è stata documentata una carica virale >50 cp/ml; i pazienti di origine non italiana presentavano un rischio aumentato di interrompere la ART (19.6% vs. 2%; p<0.001) e di fallimento virologico (8.7% vs. 1%; p<0.001). Le misure di contenimento del COVID-19 hanno avuto quindi effetti indiretti sul benessere delle persone HIV-positive; la stessa epidemia può rappresentare un’occasione per riflettere su possibili nuovi modelli di gestione delle cure.
Cuantificando daños por ilícitos antitrust, ¿quo vadimus?
Authors: Martín Martín Gustavo Andrés 
Published: March 2022

El expediente de la estimación judicial está jugando un importante papel en la determinación del daño por parte de los tribunales españoles en el caso del cártel de los camiones. Establecido el marco general de los criterios utilizados por los tribunales españoles en estos casos de cártel, cabe preguntarse por la aplicación concreta que los tribunales están realizando de dicho expediente. Del presente estudio se advierte que el expediente de estimación judicial del daño opera en dos planos diferenciados con importantes consecuencias sustantivas y procesales.
La donación mortis causa como pacto sucesorio
Authors: Goñi Urriza Natividad 
Published: March 2022

La sentencia del Tribunal de Justicia de 9 septiembre 2021 en el asunto UM se pronuncia sobre el concepto de pacto sucesorio contenido en el art. 3.1 del Reglamento 650/2012, de 4 de julio de 2012, relativo a la competencia, la ley aplicable, el reconocimiento y la ejecución de las resoluciones, a la aceptación y la ejecución de los documentos públicos en materia de sucesiones mortis causa y a la creación de un certificado sucesorio europeo.
La interpretación autónoma y uniforme del Reglamento de sucesiones debe favorecer el objetivo de ayudar a los herederos y a las personas próximas al causante y también a los acreedores de la herencia a ejercer sus derechos en situaciones de sucesión mortis causa con repercusiones transfronterizas, así como permitir a los ciudadanos de la Unión preparar su sucesión. Esta sentencia al clarificar el concepto de pacto sucesorio y determinar la aplicación del Reglamento de sucesiones facilita la identificación de la norma de Derecho Internacional Privado de la Unión a las transmisiones mortis causa y, con ello, la seguridad jurídica en las situaciones con elemento extranjero.
JOSÉ JUAN CASTELLÓ PASTOR (Dir). Desafíos jurídicos ante la integración digital: aspectos europeos e internacionales
Authors: Antón Juárez Isabel 
Published: March 2022

Este artículo reseña: José Juan Castelló Pastor (Dir), Desafíos jurídicos ante la integracióndigital:aspectos europeos e internacionales. Pamplona, Editorial Aranzadi, 2021,ISBN:978-84-1345-003-2
A2-Type Granites from the Bastar Craton, South-Central India, and Their Implication in Archean-Paleoproterozoic Tectonics in Indian Peninsula
Authors: Satpathi Kausik , Hifzurrahman  , Xie Hang-Qiang , Ganaie Ab Majeed , Misra Sagar , Nasipuri Pritam 
Published: March 2022

Abstract
This communication reports novel geochemical and geochronological data of granite from the southeastern part of the Bastar Craton, Central India. The studied samples are leucocratic in appearance and composed of quartz, K-feldspar, plagioclase feldspar, and biotite in decreasing order of abundances. Apatite, sphene, and zircon occur as accessory minerals. The SiO2 and Al2O3 content of the studied sample varies between 61 and 69 wt.% and 13 and 15 wt.%, respectively. The alkali oxides, K2O, and Na2O content ranges between 3 and 6 wt.% and 2 and 3 wt. %, respectively. In the primitive mantle normalized spider diagram, the granites exhibit a negative Nb–Ti, Sr anomaly, and a positive Pb–Th anomaly. Similarly, in the REE normalized spider plot, the granites exhibit a strongly fractionated trend La/YbCN=10.90−28.4 with a negative Eu anomaly (0.42-0.70). The zircon saturation in silicate melt yields crystallization temperature (Tzr) ~650 to 800°C for the Eastern Bastar Craton rocks. The P-T pseudosection modeling implies EBC granites which are crystallized at 700-750°C, at 0.4 to 0.6 GPa. The SHRIMP U-Pb ages from magmatic zircon yield an upper intercept at ~2470 Ma and a lower intercept at ~2100 Ma. When combined with the results of P-T pseudosection modeling, the geochemical and geochronological data classifies the Eastern Bastar Craton rocks as A2 granites that were emplaced during the amalgamation of Archean blocks leading to extended Ur formation. The ~2100 Ma age is correlated with mafic dyke emplacement and the Bastar Craton–Yilgarn Craton block disintegration before Paleoproterozoic Columbia supercontinent assembly.
Data-Driven Integrated Reservoir Development of a Mature Condensate-Rich Gas Field in the Sultanate of Oman
Authors: van Gilst Roeland , Al Kindi Ahmed , Al Balushi Naila , Abri Al Mutasem , Al Busaidy Ahmed , Al-Khusaibi Aida 
Published: March 2022

Abstract
Recent observations indicate a distinct hydrocarbon composition change in a mature condensate rich gas field in the Sultanate of Oman, which will drastically change the next development decisions.
The new insights were a result of: 1) data analysis and visualization and 2) collaboration between Development Planning (DP), Well & Reservoir Management (WRM) and Exploration. Field data such as well tests, fluid samples and production logging tests were integrated with geological concepts to deliver reservoir models that could assist late field life decision making.
The outcome of the data analysis was summarized in the so-called "Plumbing Diagram", which combines reservoir architecture, structural elements, fluid fill and a reservoir connectivity analysis. The diagram was also used as a collaboration tool between Development, WRM and Exploration, which enabled the non-core team members to quickly understand the key uncertainties, risks and opportunities.
Field data indicated vertical changes in hydrocarbon composition across the field. These new observations were combined with exploration burial diagrams and thin section analysis from core data. This led to the insight that the gas field is not just rich in condensate, but has gone through various hydrocarbon charge stages starting with an initial oil charge. A recently drilled well confirmed the existence of the oil charge with solid bitumen indicating a subsequent thermal cracking phase.
Integration with wire line log evaluations made it possible to define two field-wide fluid zones, referred to by the team as: 1) Free Gas (FG) and 2) Condensate Rich Gas (CRG). The split of the two fluid zones will have a major impact on the field Development and WRM strategy as the focus is shifting towards development of the CRG zone, which is more challenging mainly due to the fluid fill mixture of oil, bitumen, gas and condensate.
This paper describes how field data, observations and collaboration between teams improved the total hydrocarbon system understanding driving the future development decisions. The success of the changes in the development and WRM strategy will serve as blueprint for condensate rich gas fields with a similar burial and charge history in the north of Oman.