bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 booster vaccine willingness among patients with chronic kidney disease in Taizhou, China
Authors: Chen He-Dan , Xu Guang-Biao , Chen Yan , Lin Xiao-Qing , Lv Li , Tung Tao-Hsin , Zhu Jian-Sheng 
Published: August 2022

Abstract

Purpose
Investgate the willingness of CKD patients to receive a COVID-19 booster vaccine dose and analyze the related factors of COVID-19 booster vaccine willingness in such patients.
Methods
An online questionnaire investigation addressing participants’ willingness to receive a booster dose of COVID-19 vaccine was organized among patients with chronic kidney disease in Taizhou, China.
Result
A total of 350 valid copies were retrieved, among which 246 respondents (70.29%) were willing to receive a COVID-19 booster vaccine dose. Binary logistic regression analysis showed that high perceived vaccine safety and effectiveness, non-hemodialysis treatment, and one or two rounds of COVID-19 vaccine were related to COVID-19 booster vaccine willingness of CKD patients. Therefore, enhancing propaganda on safety and efficacy of COVID-19 vaccine for CKD patients, raising their awareness about vaccination, and increasing vaccination of the first and second rounds can help increase the COVID-19 booster vaccination rate.
Portable and cost-effective genetic detection and characterization of Plasmodium falciparum hrp2 using the MinION sequencer
Authors: Sabin Susanna , Jones Sophie , Patel Dhruviben , Subramaniam Gireesh , Kelley Julia , Aidoo Michael , Talundzic Eldin 
Published: August 2022

Abstract
The prevalence of Plasmodium falciparum hrp2 (pfhrp2)-deleted parasites threatens the efficacy of the most used and sensitive malaria rapid diagnostic tests and highlights the need for continued surveillance for this gene deletion. While PCR methods are generally adequate for determining pfhrp2 presence or absence, they offer a limited view of its genetic diversity. Here, we present a portable sequencing method using the MinION. Pfhrp2 amplicons were generated from individual samples, barcoded, and pooled for sequencing. To overcome potential crosstalk between barcodes, we implemented a coverage-based threshold for pfhrp2 deletion confirmation. Amino acid repeat types were then counted and visualized with custom Python scripts following de novo assembly. We evaluated this assay using well-characterized reference strains and 152 field isolates with and without pfhrp2 deletions, of which 38 were also sequenced on the PacBio platform to provide a standard for comparison. Of 152 field samples, 93 surpassed the positivity threshold, and of those samples, 62/93 had a dominant pfhrp2 repeat type. PacBio-sequenced samples with a dominant repeat-type profile from the MinION sequencing data matched the PacBio profile. This field-deployable assay may supplement the World Health Organization’s existing protocol for surveilling pfhrp2 deletions and facilitate timely implementation of diagnostic policy change when needed.
Inverse-designed universal quantum logic gates for super-compact quantum circuits
Authors: He Lu , Liu Dongning , Gao Jingxing , Zhang Huizhen , Feng Xue , Liu Fang , Cui Kaiyu , Huang Yidong , Zhang Wei , Zhang Xiangdong 
Published: August 2022

Abstract
Integrated quantum photonic circuits are a promising approach to realizing future quantum information processing. To achieve large-scale quantum photonic circuits, as many quantum logic gates as possible are expected to be integrated on chips. This requires quantum logic gates to be as small as possible. Here, we report the implementation of super-compact universal quantum logic gates on silicon photonic chips by inverse design. The sizes for the fabricated optical controlled-NOT gate and single-qubit gates (Hadamard gate) on the chip are about one vacuum wavelength, which are the smallest optical quantum gates ever verified in the world. The quantum circuit by these cascaded fundamental gates is shrunk several orders compared to those previous quantum photonic circuits that perform arbitrary quantum processing. Our study paves the way for the realization of large-scale quantum photonic chips with integrated sources for practical quantum information processes.
Impact of P pocket in Doping Less Tunnel Field Effect Transistor
Authors: Haneef Nazia Haneef Nazia , Raushan Mohd Adil Raushan Mohd Adil , Bas Md Yasir Bashir Md Yasir , Siddiqui Mohammad Jawaid Siddiqui Mohammad Jawaid 
Published: August 2022

Abstract
In this paper, we have proposed the doping less dual material double gate Tunnel field-effect transistor with a P+ pocket (PP- DMG TFET). This gate engineered technique is ordinarily used in a MOSFET for performance augmentation. The P+ pocket is embedded at the source side to enhance the performance of pocket engineered PP- DMG TFET device. This paper compares the performance of four DG-TFET based devices i.e. single material gate TFET (SMG), single material gate with P+ pocket TFET (PP-SMG), dual material gate TFET (DMG DG), dual material gate with P+ pocket (PP-DMG). Electrostatic doping based on charge plasma notion forms the requisite structure n-i-p + for tunneling formed on a thin intrinsic silicon layer. The proposed device (PP-DMG) has a high on-current capability, high ON/OFF ratio and lower point subthreshold of 15.3 mV/dec, and an average subthreshold of 18.6 mV/dec. The analog parameters evaluated include transconductance (gm) and cutoff frequency (fT) have shown impressive improvement. We have also discussed the device efficiency and transconductance frequency product (TFP) finally we have done the linearity and distortion analysis on parameters such as VIP2, VIP3, IIP3, and IMD3 analysis.
STUDY PROTOCOL
A multinational, phase 2, randomised, adaptive protocol to evaluate immunogenicity and reactogenicity of different COVID-19 vaccines in adults ≥75 already vaccinated against SARS-CoV-2 (EU-COVAT-1-AGED): A trial conducted within the VACCELERATE network
Authors: Neuhann Julia Maria , Stemler Jannik , Carcas Antonio , Frías-Iniesta Jesús , Bethe Ullrich , Heringer Sarah , Tischmann Lea , Zarrouk Marouan , Cüppers Arnd , König Franz , Posch Martin , Cornely Oliver A. 
Published: August 2022

Abstract
Background: In the ongoing COVID-19 pandemic, advanced age is a risk factor for a severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and research should focus on optimal vaccination schedules. In addition to each individual’s medical history, immunosenescence warrants further research in this population. This study investigates vaccine-induced immune response over one year.Methods/Design: EU-COVAT-1-AGED is a randomised controlled, adaptive, multicentre phase II protocol evaluating different booster strategies in individuals aged ≥75 years (n=600) already vaccinated against SARS-CoV-2. The initial protocol foresaw a 3rd vaccination (1st booster) as study intervention. The present modified Part B of this trial foresees testing of mRNA-1273 (Spikevax®) vs. BNT162b2 (Comirnaty®) as 4th vaccination dose (2nd booster) for comparative assessment of their immunogenicity and safety against SARS-CoV-2 wild-type and variants. The primary endpoint of the trial is to assess the rate of 2-fold antibody titre increase 14 days after vaccination measured by quantitative enzyme-linked immunosorbent assay (Anti-RBD-ELISA) against wild-type virus. Secondary endpoints include the changes in neutralising antibody titres (Virus Neutralisation Assay) against wild-type as well as against Variants of Concern (VOC) at 14 days and up to 12 months. T-cell response measured by qPCR will be performed in subgroups at 14 days as exploratory endpoint. Biobanking samples are being collected for neutralising antibody titres against potential future VOC. Furthermore, potential correlates between humoral immune response, T-cell response and neutralising capacity will be assessed.The primary endpoint analysis will be triggered as soon as for all patients the primary endpoint (14 days after the 4th vaccination dose) has been observed.Discussion: The EU-COVAT-1-AGED trial Part B compares immunogenicity and safety of mRNA-1273 (Spikevax®) and BNT162b2 (Comirnaty®) as 4th SARS-CoV-2 vaccine dose in adults ≥75 years of age. The findings of this trial have the potential to optimise the COVID-19 vaccination strategy for this at-risk population.
Comparison of percutaneous endoscopic interlaminar discectomy and conventional discectomy for double- segmental lumbar disc herniation: a retrospective non- randomized study
Authors: Liu Zixiang , Qin Wanjin , Tang Yingchuang , li Hanwen , Liu Hao , Yang Huilin , Mao Haiqing , Zhang Kai , Chen Kangwu 
Published: August 2022

Abstract
Objective: The objective of this study was to compare the outcomes of percutaneous endoscopic interlaminar discectomy (PEID) with the conventional lumbar discectomy (CLD) for treatment of double-segmental lumbar disc herniation (LDH).Methods: This is a retrospective non-randomized study. Forty-six patients with double-segmental LDH were enrolled. The CLD group included 14 male and 8 female patients, with the mean age of 38.0 ± 9.2 year. All the demographic files were collected, with clinical outcomes evaluated by the visual analog scale (VAS), the Oswestry Disability Index (ODI) and the modified Macnab criteria. The operation time, intra-operation exposure time, postoperative bed-rest time, hospital-stay and complications were recorded at each follow-up point.Results: Data were evaluated with a minimum of 12 months follow-up period. In both groups, the VAS and ODI scores were significantly improved. The proportion of excellent or good outcome cases in each group was 91.7% and 86.4%, respectively. Two cases from PEID group and three cases from CLD group presented complications. The bed-rest time and hospital-stay period were significantly shortened (P < 0.05), while the operation time and intra-operation exposure time were longer in PEID group as compared to CLD group (P < 0.05).Conclusions: Both PEID and CLD are safe and effective approaches for treatment of double-segmental LDH and the PEID technique is less invasive, which accelerates patients’ recovery after surgery.
Robust adaptive predefined-time control tracking for a quadrotor with disturbances
Authors: Labbadi Moussa , Abadi Amine , Tahri Omar , Djemai Mohamed 
Published: August 2022

Abstract
This article deals with the robust finite-time stabilization of a quadrotor subject to perturbations. First, new nonsingular terminal sliding mode variables (NTSMV) are proposed for altitude and attitude that speeds the controlled system’s convergence both before and after it reaches the sliding manifolds of the system. The uniqueness comes in the design of time-varying (TV) sliding surfaces without prior knowledge of the initial system states, resulting in insensitivity to beginning state uncertainty. Then, a robust TV nonsingular terminal sliding mode control scheme is developed based on the results of FTSMV, in which the singularity problem of traditional terminal sliding mode (TSM) control systems is solved by restricting TSM surfaces to non-singular areas. The proposed control strategy applied to the altitude and attitude of a quadrotor guarantees the tracking errors’ finite-time convergence to the origin, as well as the quadrotor overall robustness in the face of enormous uncertainties and unforeseen environmental perturbations. In addition, adaptive tuning laws are designed to estimate the lumped uncertainty’s unknown upper bounds, which is useful in practice, also, the stability of all proposed techniques is proved. All results are illustrated in simulations are compared to others control algorithms.
Low prevalence of current and past SARS-CoV-2 infections among visitors and staff members of homelessness services in Amsterdam at the end of the second wave of infections in the Netherlands
Authors: Generaal Ellen , Santen Daniela van , Campman Sophie , Booij Marjolein , Price Dylan , Buster Marcel , Dijk Christa van , Boyd Anders , Bruisten Sylvia , Dam Alje van , Lubben Mariken van der , Duijnhoven Yvonne van , Prins Maria 
Published: August 2022

Abstract
Background People experiencing homelessness (PEH) may be at increased risk of SARS-CoV-2 infection and severe COVID-19. The Dutch government established emergency shelters and introduced preventive measures for homelessness services and there were no major SARS-CoV-2 outbreak noticed among PEH during the first two waves of infections. This study aimed to assess the prevalence of current and past infections among PEH and staff at the end of the second COVID-19 wave by conducting an on-site COVID-19 screening project at homelessness services in Amsterdam, the Netherlands. Methods We assessed the proportion of visitors and staff members of four homelessness services at two locations in Amsterdam with positive SARS-CoV-2 qPCR and antibody results (IgG/IgM Rapid Test, Biozek) in May 2021. We also assessed sociodemographic, clinical and lifestyle characteristics, compliance with basic prevention measures and intention to vaccinate against COVID-19 among PEH and staff.Results A total of 138 visitors and 53 staff members filled out a questionnaire and were tested. Among PEH, the SARS-CoV-2 positivity rate was 0% (0/133;95%CI=0-1.9) and the antibody positivity rate was 1.6% (2/131;95%CI=0.8-7.5). Among staff, these percentages were 3% (1/32;95%CI=0.1-16.2) and 11% (5/53;95%CI=3.6-23.6), respectively. Most participants were frequently compliant with the basic preventive measures ‘not shaking hands’, ‘wearing a face mask’ and ‘washing hands’, but not with ‘physical distancing’. Overall, intention to vaccinate for COVID-19 was low (30% for visitors, 10% for staff) or medium (28% for visitors, 35% for staff). Trust in COVID-19 policies were also, for the most part, low (27% for visitors, 17% for staff) or neutral (32% for visitors, 53% for staff).Conclusions We observed a low prevalence of past and current SARS-CoV-2 infections among PEH, which may be explained by instated shelter policies, limited daily activities of PEH and compliance with certain prevention measures. Vaccine hesitancy and mistrust among visitors and staff could hinder vaccination uptake, suggesting that improvements in public heath communication and interventions towards visitors and staff of homelessness services are needed.
HPK1 inhibitor enhanced tumor response to anti-PD-1 immunotherapy in Non-Hodgkin lymphoma
Authors: Yang Lin , Zhao Qiuling , Chen Ting , Liu Wenbin , Qiu Xiuliang 
Published: August 2022

Abstract
Anti-PD-1 immunotherapy has been widely applied in patients with some types of lymphomas. The classical Hodgkin's lymphoma is highly sensitive to immunotherapy but Non-Hodgkin's lymphoma (NHL) is not good response. Therefore, it is valuable to optimize PD-1 blockade treatment in NHL patients. Studies indicated that HPK1 suppressed T cells and reduced the anti-tumor immunity. Therefore, HPK1 inhibitor may restore and elicit antitumor immune responses and is a promising candidate drug target for cancer immunotherapy. We initially explored the Gene Expression Profile Interactive Analysis (GEPIA) databases and it predicted that HPK1 expression increased in DLBCL and was associated with NLRP3. We investigated whether the HPK1 inhibitor could enhance tumor response to anti-PD-1 immunotherapy in NHL and the association between HPK1 and NLRP3. Employing shHPK1 and inhibitor, our study demonstrated that HPK1 inhibitor increased the anti-PD-1 mediated T cell cytotoxicity on BJAB and WSU-DLCL2 co-cultured with peripheral blood mononuclear cells (PBMCs). HPK1 inhibitor increased PD-1, PD-L1, Bax, p53 and NK-kB but decreased NLRP3. These indicated that HPK1 inhibitor was associated with apoptosis and NLRP3 inflammasome pathway in anti-PD-1 mediated T cell cytotoxicity. Our data also demonstrated that HPK1 inhibitor enhanced the efficiency of anti-PD-1 immunotherapy on NHL in in vivo zebrafish xenograft models. In summary, this study provided the evidence that HPK1 inhibitor enhanced tumor response to anti-PD-1 immunotherapy for NHL by promoting apoptosis and blocking NLRP3 pathway. This provides a potential therapeutic option for NHL with combination HPK1 inhibitor and anti-PD-1 immunotherapy.
MBSaNet : A combination of convolutional neural networks and self-attention for the identification of fundus diseases
Authors: Wang Keya , Xu Chuanyun , Li Gang , Zheng Yu , Sun Chengjie , Zhang Yang 
Published: August 2022

Abstract
Early detection of lesions is of great significance for treating fundus diseases. Fundus photography is an effective and convenient screening technique by which common fundus diseases can be detected. In this study, we use color fundus images to distinguish among multiple fundus diseases. Existing research on fundus disease classification has achieved some success through deep learning techniques, but there is still much room for improvement in model evaluation metrics using only deep convolutional neural network (CNN) architectures with limited global modeling ability; the simultaneous diagnosis of multiple fundus diseases still faces great challenges. Therefore, given that the self-attention (SA) model with a global receptive field may have robust global-level feature modeling ability, we propose a multistage fundus image classification model —MBSaNet —which combines CNN and SA mechanism. The convolution block extracts the local information of the fundus image, and the SA module further captures the complex relationships between different spatial positions, thereby directly detecting one or more fundus diseases in retinal fundus image. In the initial stage of feature extraction, we propose a multiscale feature fusion stem, which uses convolutional kernels of different scales to extract low-level features of the input image and fuse them to improve recognition accuracy. The training and testing were performed based on the ODIR-5k dataset. The experimental results show that MBSaNet achieves state-of-the-art performance with fewer parameters. The wide range of diseases and different fundus image collection conditions confirmed the applicability of MBSaNet.
UV assisted size modification of green synthesized silver nanoparticles, and its potential antibacterial study
Authors: S Shivananda C , B Lakshmeesha Rao , Y Sangappa 
Published: August 2022

Abstract
Silver nanoparticles (AgNPs) were successfully synthesized from aqueous silk fibroin solution by using UV-irradiation technique. Here the SF solution acts as stabilizer, the effect UV-irradiation time influence the particle size and shape of the AgNPs. The UV-Visible studies evidence the strong surface plasmon resonance (SPR) band at 428 nm, which confirm the reduction of Ag+ to Ag0 in the aqueous SF solution. Transmission electron microscope (TEM) images investigate that the AgNPs are well dispersed in aqueous SF solution, increasing the irradiation time the large number of particles agglomerates of grains with narrow size distribution. The synthesized AgNPs structurally characterized by X-ray diffraction technique. The XRD pattern the peaks are good agreement with the synthesized AgNPs are face centered cubic structure (FCC) with a lattice constant of a = 0.485. The dynamic light scattering (DLS) investigates the particle size distribution and average size of the synthesized AgNPs. The size control and UV irradiation time of AgNPs can affect the significant antibacterial activity against four bacterial stains, i.e. Staphylococcus aureus, Bacillus subtilis (Gram positive) and Escherichia coli, salmonella typhi (Gram negative).
Iteration methods to solve Sylvester equation AX+XB=C
Authors: Yu Siting , Peng Jingjing , Li Rui , Tang Zengao , Peng Zhenyun 
Published: August 2022

Abstract
In this paper, the multiple constraint least squares solution of Sylvester equation AX+XB=C is discussed. The necessary and sufficient conditions for the existence of solutions to the considered problem are given. Noting that the alternating direction method of multipliers (ADMM) is an one-step iterative method, a multi-step alternating direction method of multipliers (MSADMM) to solve the considered problem is proposed and some convergence results of the proposed algorithm are proved. Problems which should be studied in near future are listed. Numerical comparisons between MSADMM and ADMM are included.2010 Mathematics subject Classiflcations. 15A39, 65F30.
WITHDRAWN: Addressing social determinants of health is a priority for managing COVID-19 in Arctic Indigenous communities: results of a scoping review
Authors: Kolahdooz Fariba , Jang Se Lim , Deck Sarah , Ilkiw David , McKeen Jennifer , Omoro Gertrude , Rautio Arja , Pirkola Sami , Moeller Helle , Ferguson Gary , Evengard Birgitta , Mantla-Look Lianne , Milligan Crystal , DeLancey Debbie , Corriveau Andre , Irlbacher-Fox Stephanie , Wagg Adrian , Roache Cindy , Oystrek Rachel , Rittenbach Katherine , Conter Henry J , Falk Ryan , Kurtz Donna , Sharma Sangita 
Published: August 2022

Abstract
Background. Arctic Indigenous communities are unique, geographically remote and/or isolated, and currently among the most susceptible populations in the world to the effects of the coronavirus disease 2019 (COVID-19) pandemic. Since colonization, Indigenous communities have been particularly susceptible to infectious disease outbreaks. Methods. This study reviewed current knowledge regarding social determinants of health (SDH) and pandemics in Arctic Canada and highlighted the implications of the current COVID-19 pandemic on individuals, families, and communities in Arctic Canada.Studies published in English and French pertaining to SDH or pandemics in the Canadian Arctic were located using key search words in three databases (PubMed, Medline, and CINAHL) as well as reference tracking of relevant articles up to September 2021. Studies were categorized according to infectious disease (COVID-19, H1N1 influenza, and tuberculosis) or SDH (healthcare access, food security, mental health, socioeconomic status, cultural continuity, housing, and community infrastructure). NVivo was used to theme and sub-theme findings of selected studies.Results. One hundred studies were included in this scoping review. Two articles related to COVID-19, five to influenza, and five to TB; 27 healthcare access, 19 to food security, 17 to mental health, nine to SES, seven to cultural continuity, six to housing, and three to community infrastructure. Documented lessons learned from previous pandemics in Arctic communities provides evidence to inform public health policies and culturally safe programs for the current COVID-19 pandemic where many SDH exist as challenges for Indigenous communities. The SDH included limited healthcare access, food insecurity, mental health challenges, low socioeconomic status, limited cultural considerations in healthcare, and suboptimal housing. These findings are also relevant to Indigenous communities in other Arctic regions facing similar challenges due to the pandemic.Conclusions.: It is essential to understand how SDH underlie the health and wellbeing of Indigenous communities in the Arctic and to utilize this information to inform critical policy and practice decisions for COVID-19 prevention, management, and treatment. This review indicated that many SDH are unique to Canadian Arctic settings and pose specific challenges for the prevention and management of infectious diseases, such as COVID-19.