bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum biomarker-based osteoporosis risk prediction and the systemic effects of Trifolium pratense ethanolic extract in a postmenopausal model
Authors: Quah Yixian , Yi-Le Jireh Chan , Park Na-Hye , Lee Yuan Yee , Lee Eon-Bee , Jang Seung-Hee , Kim Min-Jeong , Rhee Man Hee , Lee Seung-Jin , Park Seung-Chun 
Published: June 2022

Abstract
Background
Recent years, a soaring number of marketed Trifolium pratense (red clover) extract products have denoted that a rising number of consumers are turning to natural alternatives to manage postmenopausal symptoms. T. pratense ethanolic extract (TPEE) showed immense potential for their uses in the treatment of menopause complications including osteoporosis and hormone dependent diseases. Early diagnosis of osteoporosis can increase the chance of efficient treatment and reduce fracture risks. Currently, the most common diagnosis of osteoporosis is performed by using dual-energy x-ray absorptiometry (DXA). However, the major limitation of DXA is that it is inaccessible and expensive in rural areas to be used for primary care inspection. Hence, serum biomarkers can serve as a meaningful and accessible data for osteoporosis diagnosis.

Methods
The present study systematically elucidated the anti-osteoporosis and estrogenic activities of TPEE in ovariectomized (OVX) rats by evaluating the bone microstructure, uterus index, serum and bone biomarkers, and osteoblastic and osteoclastic gene expression. Leverage on a pool of serum biomarkers obtained from this study, recursive feature elimination with a cross-validation method (RFECV) was used to select useful biomarkers for osteoporosis prediction. Then, using the key features extracted, we employed five classification algorithms: extreme gradient boosting (XGBoost), random forest, support vector machine, artificial neural network, and decision tree to predict the bone quality in terms of T-score.

Results
TPEE treatments down-regulated nuclear factor kappa-B ligand, alkaline phosphatase, and up-regulated estrogen receptor β gene expression. Additionally, reduced serum C-terminal telopeptides of type 1 collagen level and improvement in the estrogen dependent characteristics of the uterus on the lining of the lumen were observed in the TPEE intervention group. Among the tested classifiers, XGBoost stood out as the best performing classification model with the highest F1-score and lowest standard deviation.

Conclusions
The present study demonstrates that TPEE treatment showed therapeutic benefits in the prevention of osteoporosis at the transcriptional level and maintained the estrogen dependent characteristics of the uterus. Our study revealed that, in the case of limited number of features, RFECV paired with XGBoost model could serve as a powerful tool to readily evaluate and diagnose postmenopausal osteoporosis.
The pleiotropic roles of adipocyte secretome in remodeling breast cancer
Authors: Zhou Xiaomei , Zhang Jun , Lv Wenchang , Zhao Chongru , Xia Yu , Wu Yiping , Zhang Qi 
Published: June 2022

Abstract
Background
Breast cancer is the leading female cancer type and the cause of cancer-related mortality worldwide. Adipocytes possess important functions of energy supply, metabolic regulation, and cytokine release, and are also the matrix cell that supports mammary gland tissue. In breast cancer tumor microenvironment (TME), adipocytes are the prominent stromal cells and are implicated in inflammation, metastatic formation, metabolic remodeling, and cancer susceptibility.

Main body
It is well-established that adipocyte secretome is a reservoir engaged in the regulation of tumor cell behavior by secreting a large number of cytokines (IL-6, IL-8, and chemokines), adipokines (leptin, adiponectin, autotaxin, and resistin), lipid metabolites (free fatty acids and β-hydroxybutyrate), and other exosome-encapsulated substances. These released factors influence the evolution and clinical outcome of breast cancer through complex mechanisms. The progression of breast cancer tumors revolves around the tumor-adipose stromal network, which may contribute to breast cancer aggressiveness by increasing the pro-malignant potential of TME and tumor cells themselves. Most importantly, the secretome alterations of adipocytes are regarded as distinctly important targets for breast cancer diagnosis, treatment, and drug resistance.

Conclusion
Therefore, this review will provide a comprehensive description of the specific adipocyte secretome characteristics and interactions within TME cell populations, which will enable us to better tailor strategies for tumor stratification management and treatment.
Narrative review on the management of moderate-severe atopic dermatitis in pediatric age of the Italian Society of Pediatric Allergology and Immunology (SIAIP), of the Italian Society of Pediatric Dermatology (SIDerP) and of the Italian Society of Pediatrics (SIP)
Authors: Galli Elena , Fortina Anna Belloni , Ricci Giampaolo , Maiello Nunzia , Neri Iria , Baldo Ermanno , Berti Irene , Bonamonte Domenico , Capra Lucetta , Carboni Elena , Carello Rossella , Caroppo Francesca , Cavagni Giovanni , Chinellato Iolanda , Cipriani Francesca , Comberiati Pasquale , Diociaiuti Andrea , Di Lernia Vito , Duse Marzia , Filippeschi Cesare , Giannetti Arianna , Giovannini Mattia , Licari Amelia , Marseglia Gian Luigi , Pace Manuela , Patrizi Annalisa , Pajno Giovanni Battista , Peroni Diego , Villani Alberto , Eichenfield Lawrence 
Published: June 2022

AbstractCurrently, there are a few detailed guidelines on the overall management of children and adolescents with moderate-severe atopic dermatitis. AD ​​is a complex disease presenting with different clinical phenotypes, which require an individualized and multidisciplinary approach. Therefore, appropriate interaction between primary care pediatricians, pediatric allergists, and pediatric dermatologists is crucial to finding the best management strategy. In this manuscript, members of the Italian Society of Pediatric Allergology and Immunology (SIAIP), the Italian Society of Pediatric Dermatology (SIDerP), and the Italian Society of Pediatrics (SIP) with expertise in the management of moderate-severe atopic dermatitis have reviewed the latest scientific evidence in the field. This narrative review aims to define a pathway to appropriately managing children and adolescents with moderate-severe atopic dermatitis.
Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas
Authors: Li Hui-hui , Sai Lin-tao , Liu Yuan , Freel Colman I. , Wang Kai , Zhou Chi , Zheng Jing , Shu Qiang , Zhao Ying-jie 
Published: June 2022

Abstract
Background
Systemic lupus erythematosus (SLE) can cause placental dysfunctions, which may result in pregnancy complications. Long noncoding RNAs (lncRNAs) are actively involved in the regulation of immune responses during pregnancy. The present study aimed to determine the lncRNA expression profiles in placentas from women with SLE to gain new insights into the underlying molecular mechanisms in SLE pregnancies.

Methods
RNA sequencing (RNA-seq) analysis was performed to identify SLE-dysregulated lncRNAs and mRNAs in placentas from women with SLE and normal full-term (NT) pregnancies. Bioinformatics analysis was conducted to predict the biological functions of these SLE-dysregulated lncRNAs and mRNAs.

Results
RNA-seq analysis identified 52 dysregulated lncRNAs in SLE placentas, including 37 that were upregulated and 15 downregulated. Additional 130 SLE-dysregulated mRNAs were discovered, including 122 upregulated and 8 downregulated. Bioinformatics analysis revealed that SLE-dysregulated genes were associated with biological functions and gene networks, such as regulation of type I interferon-mediated signaling pathway, response to hypoxia, regulation of MAPK (mitogen-activated protein kinase) cascade, response to steroid hormone, complement and coagulation cascades, and Th1 and Th2 cell differentiation.

Conclusions
This is the first report of the lncRNA profiles in placentas from SLE pregnancies. These results suggest that the aberrant expression and the potential regulatory function of lncRNAs in placentas may play comprehensive roles in the pathogenesis of SLE pregnancies. SLE-dysregulated lncRNAs may potentially serve as biomarkers for SLE.
Growth rate determines prokaryote-provirus network modulated by temperature and host genetic traits
Authors: Liu Zhenghua , Yan Qingyun , Jiang Chengying , Li Juan , Jian Huahua , Fan Lu , Zhang Rui , Xiao Xiang , Meng Delong , Liu Xueduan , Wang Jianjun , Yin Huaqun 
Published: June 2022

AbstractBackgroundProkaryote-virus interactions play key roles in driving biogeochemical cycles. However, little is known about the drivers shaping their interaction network structures, especially from the host features. Here, we compiled 7656 species-level genomes in 39 prokaryotic phyla across environments globally and explored how their interaction specialization is constrained by host life history traits, such as growth rate.ResultsWe first reported that host growth rate indicated by the reverse of minimal doubling time was negatively related to interaction specialization for host in host-provirus network across various ecosystems and taxonomy groups. Such a negative linear growth rate-specialization relationship (GrSR) was dependent on host optimal growth temperature (OGT), and stronger toward the two gradient ends of OGT. For instance, prokaryotic species with an OGT ≥ 40 °C showed a stronger GrSR (Pearson’sr= −0.525,P< 0.001). Significant GrSRs were observed with the presences of host genes in promoting the infection cycle at stages of adsorption, establishment, and viral release, but nonsignificant with the presence of immune systems, such as restriction-modification systems and CRISPR-Cas systems. Moreover, GrSR strength was increased with the presence of temperature-dependent lytic switches, which was also confirmed by mathematical modeling.ConclusionsTogether, our results advance our understanding of the interactions between prokaryotes and proviruses and highlight the importance of host growth rate in interaction specialization during lysogenization.
A scrutiny of the relationship between cognitive load and difficulty estimates of language test items
Authors: Noroozi Shadi , Karami Hossein 
Published: June 2022

AbstractRecently, researchers have expressed their growing concern over the scrutiny of language test items in light of cognitive load theory (CLT). While cognitive load has been central to language learning research, it has not enjoyed due attention in high-stakes language tests. The current study set out to delve into the relationship between difficulty estimates and cognitive load of language test items. To measure cognitive load, examinees’ perceived level of difficulty and response time were considered. In this regard, empirical data were collected from 60 MA students and graduates through a quantitative correlational design. The current study further employed the Rasch model to estimate difficulties of the vocabulary and grammar items of the Iranian university entrance examination (IUEE) for MA in English majors held in 2018 and 2019. The study’s findings revealed statistically significant correlations between difficulty estimates and perceived level of difficulty for vocabulary items. As for grammar items, no statistically significant correlations were detected between the variables. Whereas the results indicated strong positive correlations between response time and difficulty estimates regarding vocabulary items, no statistically significant correlations were observed between the variables concerning grammar items. All in all, perceived level of difficulty, response time, and difficulty estimates appeared to be sound indicators of cognitive load with respect to vocabulary test items, but not with regard to grammar test items. The implications of the findings will be discussed.
A cross-cultural study of the proximity of clothing to self between millennial women in South Korea and Mongolia
Authors: Choi Sun Young , Jo Jeyeon , Lee Yuri , Ha Jisoo , Lee Joeun 
Published: June 2022

AbstractAs a part of material culture, clothing embodies the cultural specificity based on the influence of that culture on individuals. The cultural value model of Hofstede broadly describes the dimensional characteristics of each country. At the same time, the proximity of clothing to a self-scale represents the level of psychological closeness of clothing to identity. Even though it is theoretically correct that these two concepts—culture and clothing that expresses one’s self—are related, few studies have highlighted this connection. In this study, we investigated the effect of cultural values on how the individuals involve their clothing with their social identity by focussing on the differences between two culturally different countries: South Korea and Mongolia. Quantitative surveys from 179 in South Korea and 262 in Mongolia and t-tests showed cultural differences in both countries’ individualism and indulgence vs their restrained disposition. The multiple regression analysis results revealed that uncertainty avoidance and indulgence correlate with three dimensions in the proximity of clothing to self: clothing to self as structure, clothing as a response to others’ judgements, and clothing-related to self-esteem. The moderating effect of each country was not found. This result implies that knowing the cultural values of a particular group can infer their clothing consciousness. Thus, when fashion companies target millennial women in South Korea and Mongolia and establish a more significant presence abroad, examining a country’s or a group’s culture helps identify the target market's clothing perceptions.
Falciform ligament abscess with disseminated intrahepatic foci: a case report
Authors: Kuribara Tadao , Shigeyoshi Itaru , Ichikawa Tatsuo , Osa Kiyoshi , Inoue Takeshi , Ono Satoshi , Asanuma Kozo , Kaneko Shiori , Sano Takayuki , Matsubara Kouta , Irie Naoko , Suzuki Kanako , Iai Akira , Ishizu Hideki 
Published: June 2022

AbstractBackgroundFalciform ligament abscess (FLA) is a rare disease, and its diagnosis can be challenging without typical image findings of an abscess. We report a patient with FLA that presented as a mass, with an indistinct border between it and the liver, in addition to disseminated foci within the liver. This made it difficult to determine whether it was FLA or a malignancy.Case presentationA 69-year-old man presented with epigastric pain. Contrast-enhanced computed tomography revealed a 25-mm mass below the middle of the diaphragm. Based on an initial diagnosis of infection of the falciform ligament, we administered conservative antibiotic treatment and there was initial improvement in the patient’s clinical condition and laboratory data. However, he continued to experience mild epigastric pain. A month later, imaging studies revealed enlargement of the falciform ligament mass and the emergence of a new nodule in the liver, whereas laboratory findings showed re-elevated C-reactive protein levels. Since conservative treatment had failed, we decided to perform surgery. Considering the imaging study findings, malignant disease could not be ruled out. Based on the operative findings, we performed combined resection of the falciform ligament, left liver, and gallbladder. Histopathological examination of the resected specimens revealed extensive neutrophil infiltration and the presence of giant cells and foam cells within the lesions. These findings were indicative of abscess.Pseudomonas aeruginosawas cultured from the pus in the falciform ligament mass and bile in the gallbladder. Although multiple abscesses postoperatively developed in the residual portion of the liver, they could be treated through antibiotic therapy.ConclusionsFLA can spread to both adjacent and distant organs via its rich vascular and lymphatic networks. When FLA displays atypical image findings and/or an atypical clinical course, it can be difficult to distinguish it from malignant disease. In such cases, surgical treatment, with intraoperative pathological diagnosis, should be attempted.
Anemia and its associated factor among adolescent school girls in GODEY and DEGEHABUR council Somali region, eastern Ethiopia
Authors: Ahmed Abdirahman , Mohammed Abdulkarim 
Published: June 2022

AbstractA cross-sectional study was conducted in a higher secondary school in Godey and Degehabur council to estimate the prevalence of anaemia among school-going adolescent girls and to identify the associated factors. Haemoglobin levels were assessed directly in the school. Data related to socio-demographic, socio-economic characteristics, dietary habits, past health status and anaemia related knowledge among adolescents’ girls were collected by interview method and analyzed with the help of SPSS version 25. The prevalence of anaemia was found to be 31.5% among adolescent girls. Family size ≥5 people and lack of anaemia knowledge were independent predictors of anaemia. Therefore, the present study emphasizes the need for development of health and nutrition education strategies to improve dietary habits, family planning, and intermittent iron-folic acid supplementation with intensifying adolescent anemia prophylaxis programs.
Efficacy of a digital cognitive behavioral therapy for insomnia in people with low back pain: a feasibility randomized co-twin and singleton-controlled trial
Authors: Ho Kevin K. N. , Simic Milena , Pinheiro Marina B. , Miller Christopher B. , Ferreira Manuela L. , Grunstein Ronald R. , Hopper John L. , Ordoñana Juan R. , Ferreira Paulo H. 
Published: June 2022

Abstract
Background
Digital cognitive behavioral therapy for insomnia (CBT-i) in people with low back pain (LBP) may be efficacious in improving both sleep and pain; and twin trial designs provide greater precision of treatment effects by accounting for genetic and early environmental factors. We aimed to determine the feasibility of a trial investigating the efficacy of a digital CBT-i program in people with comorbid symptoms of insomnia and LBP, in twins and people from the general community (singletons).

Methods
Thirty-two twins (16 pairs) and 66 singletons with comorbid symptoms of insomnia and LBP (> 6 weeks duration) were randomized to digital CBT-i (intervention) or educational program (control) for 6 weeks. The digital CBT-I, Sleepio (developed by Big Health Inc.), was an online interactive, automated, personalized course comprising of six sessions, once a week. The education program was six emails with general sleep information, once a week. Participants were blinded to their group allocation and offered the alternative intervention at the completion of the study. Feasibility outcomes included recruitment and follow-up rates, data collection and outcome measure completion, contamination (communication about trial interventions), acceptability (adherence), credibility, and participants’ experience of the intervention.

Results
Sixteen out of 722 contacted twin pairs were recruited (recruitment rate = 2.2%). Twins were recruited between September 2015 and August 2018 (35 months) and singletons between October 2017 and Aug 2018 (10 months). Follow-up rates for post-intervention and 3-month follow-up were 81% and 72% for twins and 82% and 78% for singletons respectively. Adherence rates (percentage of sessions completed out of six) for the digital CBT-i were 63% for twins and 55% for singletons. Contamination (speaking about the study to each other) was present in two twin pairs (13%). Written or verbal feedback (n = 21) regarding the digital CBT-i intervention from participants were positive (n = 11), neutral (n = 5), or negative (n = 6).

Conclusions
Online CBT-i was received favorably with people with comorbid symptoms of insomnia and LBP. While the online data collection was successful, strategies need to be implemented to improve adherence, follow-up, control group credibility (for digital CBT-i), and twin recruitment rates (for twin trials).

Trial registration
Australian New Zealand Clinical Trials Registry (ACTRN12615000672550). Registered 29 June 2015
Exploring how to improve access to psychological therapies on acute mental health wards from the perspectives of patients, families and mental health staff: qualitative study
Authors: Berry Katherine , Raphael Jessica , Haddock Gillian , Bucci Sandra , Price Owen , Lovell Karina , Drake Richard J. , Clayton Jade , Penn Georgia , Edge Dawn 
Published: June 2022

Background
Psychological therapy is core component of mental healthcare. However, many people with severe mental illnesses do not receive therapy, particularly in acute mental health settings.

Aims
This study identifies barriers to delivering and accessing psychological therapies in acute mental health settings, and is the first to recommend how services can increase access from the perspectives of different stakeholders (staff, patients and carers).

Method
Sixty participants with experiences of acute mental health wards (26 staff, 22 patients and 12 carers) were interviewed about barriers to accessing therapy in in-patient settings and how therapies should be delivered to maximise access.

Results
Four themes were identified: (a) ‘Models of care’, including the function of in-patient wards, beliefs about the causes of mental health problems and the importance of strong leadership to support psychosocial interventions; (b) ‘Integrated care’, including the importance of psychologists being ward-based, as well as having strong links with community teams; (c) ‘Acute levels of distress’, including factors that aggravate or ameliorate the impact of this on engagement in therapy; and (d) ‘Enhancing staff capability and motivation’, which is influenced by contextual issues.

Conclusions
It is possible to improve access to therapy through strong leadership (that is supportive of talking treatments), flexible delivery of therapy (that considers short admissions) and a whole-systems approach that promotes ward staff understanding of the psychosocial causes of mental illness and staff well-being. It is essential to ensure continuity between in-patient and community therapy services, and for wards to have physical space to carry out therapy.