bluuebunny/crossref_metadata_2025_split huggingface dataset:
The temperature effect on the compressive performance of laminated bamboo lumber
Authors: Xu Wei , Li Haitao , Chen Chen , Yao Lianshu , Corbi Ottavia 
Published: September 2022

Abstract
In order to study the temperature effect on the compression performance of laminated bamboo lumber (LBL), a total of 11 temperatures were set, and 198 specimens were tested in three loading directions: parallel to the grain, perpendicular to the grain in the flatwise and edgewise section. Based on the results, the color changes and failure modes at different temperatures were analyzed. The difference of the failure process under different temperatures was compared, and the changes of the microstructure such as the vascular bundle were observed, which was helpful to further discuss the influence of temperature on the failure mechanism of LBL. It was found that the compressive strength parallel to the grain is obviously greater than that perpendicular to the grain, and the compressive strength perpendicular to the grain in the flatwise and edgewise section was close. The results showed that the average compressive strength of the specimens in three loading directions at 20℃ was 45.07 MPa, 12.13 MPa, and 10.75 MPa respectively. Compared with that, the compressive strength in three directions increased by more than 80% at low temperature (-60℃), and the loss of compressive strength exceeded 70% at high temperature (200℃). Therefore, an empirical formula of compressive strength reduction (increase) factor was established by regression analysis.
The effect of delaying composite resin restoration after silver diamine fluoride pretreatment on the Shear Bond Strength of the final restoration : An in-vitro study
Authors: Aboulsaood Eman H. , Bakry Niveen S. , Zeitoun Sarah I. , Aboulgheit Salma A. 
Published: September 2022

AbstractBackground:Silver Diamine Fluoride (SDF) is a promising caries arresting material that can prevent recurrent caries when applied prior to composite resin. However, SDF can negatively affect the shear bond strength (SBS) of dental adhesives. Thus, the aim of the current study was to investigate the effect of delaying final restoration for one week after SDF pretreatment on shear bond strength of composite resin.Materials and methods:Sixty-six extracted sound primary teeth were randomly allocated to one of three groups as follows ; Group 1 (Control group): composite restoration without pretreatment, group 2: 38% SDF pretreatment + immediate composite restoration, group 3: 38% SDF pretreatment + 1-week aging + composite restoration. Each group was further divided into two subgroups according to the bonding protocol used as follows: (Subgroup ER) etch-and-rinse technique and (Subgroup SE) self-etch technique. SDF and composite resin were applied to the flattened buccal dentinal surfaces. SBS was measured using universal testing machine. Mode of failure was assessed by stereomicroscope. Elemental contents and depth of penetration were assessed using energy dispersive x-ray stereoscopy (EDS).Results:A statistically significant difference in mean SBS was found between group 2 (39.88±27.35) and group 1 (85.17 ± 40.43), but no significant difference was found between group 3 (96.70 ± 30.28)and group 1 (85.17 ± 40.43). Moreover, there was a statistically significant difference in mean SBS between subgroup 2ER (52.23 ± 30.13) and 2SE (27.53± 18.11). EDS analysis revealed deeper penetration of silver ions over time.Conclusions: Delaying composite resin restoration bonding to primary dentin for one week after SDF pretreatment eliminated any negative impact on SBS of the final restoration.
High-resolution structural variation catalogue in a large-scale whole genome sequenced bovine family cohort data
Authors: Lee Young-Lim , Bosse Mirte , Takeda Haruko , Moreira Gabriel Costa Monteiro , Karim Latifa , Druet Tom , Oget-Ebrad Claire , Coppieters Wouter , Veerkamp Roel F. , Groenen Martien A. M. , Georges Michel , Bouwman Aniek C. , Charlier Carole 
Published: September 2022

Abstract

Background
Structural variations (SVs) are chromosomal segments that differ between genomes, such as deletions, duplications, insertions, inversions and translocations. The genomics revolution enabled the discovery of sub-microscopic SVs via array and whole-genome sequencing (WGS) data, paving the way to unravel the functional impact of SVs. Recent human expression QTL mapping studies demonstrated that SVs play a disproportionally large role in altering gene expression, underlining the importance of including SVs in genetic analyses. Therefore, this study aimed to generate and explore a high-quality bovine SV catalogue exploiting a unique cattle family cohort data (total 266 samples, forming 127 trios).
Results
We curated 13,731 SVs segregating in the population, consisting of 12,201 deletions, 1,509 duplications, and 21 multi-allelic CNVs (> 50-bp). Of these, we validated a subset of copy number variants (CNVs) utilising a direct genotyping approach in an independent cohort, indicating that at least 80% of the CNVs are true variants, segregating in the population. Among gene-disrupting SVs, we prioritised two likely high impact duplications, encompassing ORM1 and POPDC3 genes, respectively. Liver expression QTL mapping results revealed that these duplications are likely causing altered gene expression, confirming the functional importance of SVs. Although most of the accurately genotyped CNVs are tagged by single nucleotide polymorphisms (SNPs) ascertained in WGS data, most CNVs were not captured by individual SNPs obtained from a 50K genotyping array.
Conclusion
We generated a high-quality SV catalogue exploiting unique whole genome sequenced bovine family cohort data. Two high impact duplications upregulating the ORM1 and POPDC3 are putative candidates for postpartum feed intake and hoof health traits, thus warrants further investigation. Generally, CNVs were in low LD with SNPs on the 50K array. Hence, it remains crucial to incorporate CNVs via means other than tagging SNPs, such as investigation of tagging haplotypes, direct imputation of CNVs, or direct genotyping as done in the current study. The SV catalogue and the custom genotyping array generated in the current study will serve as valuable resources accelerating utilisation of full spectrum of genetic variants in bovine genomes.
Allogeneic Blood or Marrow Transplantation with Post-transplantation Cyclophosphamide for Peripheral T-cell Lymphoma: Importance of Graft Source
Authors: Sterling Cole , Hughes Michael , Tsai Hua-Ling , Yarkony Kathryn , Fuchs Ephraim , Swinnen Lode , Paul Suman , Bolaños-Meade Javier , Luznik Leo , Imus Philip , Ali Syed , Jain Tania , Ambinder Alexander , DeZern Amy , Huff Carol , Gocke Christian , Varadhan Ravi , Wagner-Johnston Nina , Jones Richard John , Ambinder Richard 
Published: September 2022

Abstract

While allogeneic blood or marrow transplantation (alloBMT) is an effective therapy for peripheral T-cell lymphoma (PTCL), the optimal approach in this patient population remains to be determined. Here we review outcomes in 65 consecutive patients with PTCL who underwent alloBMT with non-myeloablative (NMA) conditioning and post-transplantation cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis. The graft source was bone marrow (BM) in 46 patients (71%) and peripheral blood (PB) in 19 patients (29%); all patients in the BM cohort received 200 cGy TBI, and most in the PB cohort (15/19) received 400 cGy TBI. With a median follow up of 2.8 years (range, 290 days-14.2 years), the 2-year PFS for the entire cohort was 49% (95% confidence interval [CI] 38–64%), and the 2-year OS was 55% (95% CI 44–69%). Outcomes were significantly improved in those receiving PB, including 2-year PFS of 79% (95% CI 63–100%) vs. 39% (95% CI 27–56%), 2-year OS of 84% (95% CI 69–100%) vs. 46% (95% CI 33–63%), and 1-year cumulative incidence of (CuI) relapse of 5% (95% CI 0–16%) vs. 33% (95% CI 19–46%), with no difference in GVHD or non-relapse mortality (NRM).
Adherence of kelp (Saccharina latissima) gametophytes on ropes with different binder treatments and flow regimes
Authors: Visch Wouter , Larson Ann , Åberg Per , Toth Gunilla B. 
Published: September 2022

Abstract
The cultivation of kelp typically involves two stages, where an indoor hatchery phase proceeds the grow-out phase at-sea. The in situ adhesion of microscopic propagules onto specifically designed substrates using binders has been proposed as an alternative to conventional hatchery methods where juvenile seaweeds are cultured on seeded twine, aimed at saving resources while increasing productivity as it obviates the hatchery phase. Here we tested how well kelp (Saccharina latissima) gametophytes adhere to cultivation ropes using two binder types (agar and κ-carrageenan) and application treatment (separate or mixed application) under two ecologically relevant flow regimes (5 and 15 cm s− 1), and a control condition (0 cm s− 1) in a laboratory flume. Our findings indicate that the effectiveness of a binder to retain S. latissima gametophytes onto cultivation rope, measured by the sporophyte density, was comparable for all binder types in the high flow velocity (15 cm s− 1) treatments, including the non-binder control treatment. Sporophyte densities were highest in the low flow velocities (0 and 5 cm s− 1) in the absence of a binder compared to all other treatment combinations. In conclusion, our results highlight that the effectiveness of binder assisted seeding of kelp propagules did not differ between the binder and non-binder treatments and was unaffected by flow velocities for the binder treatments. These findings are important in the development of novel methods and further optimisation of existing binder-based methods aimed at retaining seaweed propagules onto cultivation rope.
The association between concomitant rheumatoid arthritis and peripheral arterial and health-related quality of life and functional capacity: a systematic review
Authors: Zoubi Tayser , Hendry Gordon 
Published: September 2022

Abstract
Background
Patients with rheumatoid arthritis (RA) are at an increased risk of cardiovascular disease and vascular morbidity. The association between peripheral arterial disease (PAD) and RA has not been previously investigated within the scope of a review. Conjoined disease manifestations may impact patient well-being, perpetuating increased mortality and quality of life deficits.
Objective
To investigate the association between RA and PAD, along with RA and the ankle-brachial pressure index (ABPI). The impact of disease concomitance on health-related quality of life (HRQOL) and functional capacity (FC) was also investigated.
Methods
Individual study appraisal was completed using the Crowe Critical Appraisal Tool (CCAT). A level of evidence analysis was conducted using the American Society of Plastic Surgeons (ASPS) Evidence Rating Scale for Prognostic/Risk Studies. Data Sources: AMED®, CINAHL®, Health Source: Nursing/Academic Edition, MEDLINE®, AHFS®, Cochrane Library and Google scholar.
Results
10 studies produced a CCAT rating of ≥ 30 (75%) and were deemed high quality, while a single study demonstrated a score of 26 (65%) indicating moderate quality. A grade “II” level of evidence was determined for a positive association between RA and PAD. A grade of “I” was assigned to the association between ABPI and RA. The impact of concomitant manifestations on HRQOL and FC did not qualify for a level of evidence analysis.
Conclusion
The systematic inflammatory nature of RA likely contributes to the increased incidence of PAD within the population. Further investigations are required to ascertain the impact of conjoined disease manifestations on HRQOL and FC.
Implementing Big Data Analytic Platform in Healthcare The Israeli experience
Authors: Tal Orna , Rapoport Micha J. 
Published: September 2022

Abstract
Background: Medical big-data processing enables analysis of complex multifactorial clinical situations, assessing medical decisions alongside hospital strategic planning and business goals. However, accessing this data is challenging due to legal-ethical, technical and methodological barriers. It also requires the cooperation of multiple partners. Other health systems also struggle to balance scientific innovation and regulations.Purpose: to establish a practical functional integrative model to overcome these substantial barriers.Methods: An anonymous big data cloud based data warehouse was created de novo using artificial intelligence algorithm. Major barriers to data access and anonymization were identified and targeted solutions were constructed.Results: An operating model provided secured anonymous data to ongoing four internal research projects in a single tertiary state medical center. Additional four state medical centers joined the program.Conclusions: our experience demonstrates the feasibility of creating an integrated functional dynamic medical big data, accessible by multiple users in a virtual cloud. Further studies will determine its cost-effectiveness and potential value for medical research and biomedical industry.A step by step implementation, involving all relevant stakeholders enables an acceptable national model despite local barriers.
Phosphorus use efficiency, uptake and apparent balance response to substituting long-term chemical fertilizer with organic fertilizer in a double-rice cropping system
Authors: Hayatu Nafiu , Yiren Liu , Shuxiang Zhang , Jing Huang , Tianfu Han , Jiangxue Du , Khan Muhammad Numan , Daba Nano Alemu , Zhenzhen Lv , Hongqian Hou , Xianjin Lan , Jianhua Ji , Huimin Zhang 
Published: September 2022

Abstract

The overuse of chemical phosphorus (P) fertilizer commonly practiced in southern China can reduce P use efficiency and threaten environmental safety. To greatly exploit organic manure and reduce the rate of chemical fertilizer; a 35-year fertilization study was conducted under continuous double-rice cropping system to assess the long-term effects of replacing chemical fertilizer by organic fertilizer on grain yield, P use efficiency, uptake and balance. Treatments involved an unfertilized control (CK), chemical phosphorus and potassium fertilizer (PK), chemical nitrogen and phosphorus fertilizer (NP), chemical NK fertilizer (NK), chemical NPK fertilizer (NPK), and 30% NPK fertilizer with 70% organic manure (NPKM). The results revealed that the grain yield was more than 11.0 t ha-1 with NPK and NPKM treatments during 1984-2018. The grain yield with NPKM treatment was significantly (p<0.05) higher than with NPK treatment, except during 1984-1995. The soil P contents and P uptake were significantly (p<0.05) increased under manure amended treatment. The mean P use efficiencies under PK, NP, NPK and NPKM treatments were 10.7%, 20.2%, 36.1% and 44.2%, respectively. Phosphorus balance was positive under treatments with P addition, and negative in the without P addition treatments. Soil properties and P input were the key factors regulating P uptake and balance, and P activation coefficient. The results suggested that relatively high grain yield and P use efficiency can be achieved through rational chemical fertilizer, but, substituting 70% of the chemical fertilizer with manure might be the promising strategy seeing the increases in the soil fertility and P use efficiency.
The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
Authors: Berthold Elisabet , Dahlberg Alma , Jöud Anna , Tydén Helena , Månsson Bengt , Kahn Fredrik , Kahn Robin 
Published: September 2022

Abstract

Background
Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.
Methods
The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980–2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all health care contacts in the region, from 1998 to 2019. We used Cox proportional models for the calculation of hazard ratios.
Results
During the study period, 1998 to 2019, 93 (14.5%) of the individuals in the JIA group were diagnosed with depression, and 111 (17.3%) with anxiety. Corresponding numbers among the references was 474 (14.8%) with depression and 557 (17.4%) with anxiety. Hazard ratio for depression was 1.1 (95% CI 0.9–1.5) in females and 0.8 (95% CI 0.5–1.4) in males, and for anxiety 1.2 (95% CI 0.9–1.5) in females and 0.6 (95% CI 0.4–1.1) in males. There were no statistically significant hazard ratios when analyzing subgroups of JIA patients with long disease duration or treatment with disease-modifying antirheumatic drugs.
Conclusions
Individuals with JIA do not have any statistically increased risk of depression or anxiety compared to matched references.
Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT in mammary organoids
Authors: Chanda Ayan , Sarkar Anusi , Deng Lili , Bonni Azad , Bonni Shirin 
Published: September 2022

Abstract
Protein post-translational modification by the small ubiquitin-like modifier (SUMO) regulates the stability, subcellular localization, and interactions of protein substrates with consequences on cellular responses including epithelial-mesenchymal transition (EMT). Transforming growth factor beta (TGFβ) is a potent inducer of EMT with implications in cancer invasion and metastasis. The transcriptional coregulator SnoN suppresses TGFβ-induced EMT in a sumoylation-dependent manner, but the underlying mechanisms have remained largely unknown. Here, we find that sumoylation promotes the interaction of SnoN with the epigenetic regulators histone deacetylase 1 (HDAC1) and histone acetylase p300 in epithelial cells. In gain and loss of function studies, HDAC1 suppresses, whereas p300 promotes, TGFβ-induced morphogenetic changes associated with EMT in three-dimensional multicellular structures derived from mammary epithelial cells or carcinomas. These findings suggest that sumoylated SnoN acts via regulation of histone acetylation to modulate EMT in breast cell organoids. Our study may facilitate the discovery of new biomarkers and therapeutics in breast cancer and other epithelial cell-derived cancers.
Serum lipids profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-centre retrospective study
Authors: Xu Yunyi , Zhao Yiqi , Xu Xiaoqin , Yan Qiqi , Yang Liwei 
Published: September 2022

Abstract
Backgroud: Thyroid function was widely considerated as one of regulators in lipids metabolism. Studies on lipids metabolism in the pregnant women with low FT4 levels are few and inconclusive. Because it is not known whether maternal FT4 deficiency during pregnancy is associated with adverse metabolic parameters, our study aimed to further investigate the association between maternal FT4 levels and lipids profile and the therapeutic effects of levothyroxine treatment(L-T4) on these lipids profile.Methods: This retrospective study comprised 164 IH patients(FT4 levels below the 5th percentile with normal serum thyroid-stimulating hormone(TSH) levels according to the gestational-specific reference range established by Zhejiang Provincial People's Hospital previously) and 208 euthyroidism(CON group) who had regular antenatal checks at this hosptial from 2019 to 2021. IH patients were divided into levothyroxine treatment group(Treatment group, n=77) and dietary iodine supplement group(Non-Treatment group, n=87) owing to the hospital’s treatment policy and clinical experience. The intervention lasted at least 4 weeks. Metabolic parameters, including thyroid function and lipids parameters, were collected at least two times before and after the intervention. Several general characteristics were included likewise, such as maternal age, history of abortion, progestation body mass index(BMI) and gestational weight gain(Fig. 1). Results: Compared with the CON group, the IH group displayed higher levels of dyslipidaemia, reflected in elevated total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C), and apolipoprotein B(Apo B). In IH patients, a significant and negative correlation was found between FT4 and TG levels, which remained after adjusting for progestation BMI. After levothyroxine treatment, the Treatment group demonstrated a significantly slower rate of progression of hypercholesterolaemia during pregnancy. In addition, there was a relationship between the therapeutic effect and the degree of disease, with the main factors being FT4, TSH and TG levels prior to starting treatment. Conclusions: Low FT4 level status is associated with elevated blood lipids. Thyroid function and lipid levels could be improved to some extent after medical intervention in IH patients.
Rapid immune perturbations during sepsis and necrotising enterocolitis in preterm babies
Authors: Das Abhishek , Ariyakumar Gaayathri , Kamdar Shraddha , Barugahare Adele , Deveson Deanna , Gee Sarah , Costeloe Kate , Davey Martin , Fleming Paul , Gibbons Deena 
Published: September 2022

Abstract
Deaths complicated by infection are a major cause of mortality in preterm babies. Here we study the influence of bacterial sepsis and the gut inflammatory disorder necrotising enterocolitis (NEC), frequently associated with bacterial complications, on host immune dysregulation in extremely preterm babies. We identify a peripheral blood immune signature that distinguishes sepsis and NEC from other cases of suspected, though microbiologically unconfirmed, sepsis. Some signature traits could even make this distinction in babies with low or undetectable C-reactive protein, a common clinical test to alert infection. Our analysis incorporates longitudinal single-cell genomic evaluation of peripheral blood immune cells, elucidating amphiregulin as a key differentially expressed gene during sepsis and NEC, which was validated as a plasma analyte that correlated with disease-associated clinical signs. Collectively, signature immune traits provide insight into dysregulated sepsis and NEC-associated pathways and highlight candidate markers, pending validation, that could improve diagnostic-led, targeted antibiotic prescribing.