bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource
Authors: Styrkarsdottir Unnur , Lund Sigrun H. , Thorleifsson Gudmar , Saevarsdottir Saedis , Gudbjartsson Daniel F. , Thorsteinsdottir Unnur , Stefansson Kari 
Published: October 2022

ObjectiveThe level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an independent population.MethodsIn this study, 1,462 plasma proteins were measured in 54,265 participants from the UK Biobank on the Olink Explore platform. We analyzed the association of plasma proteins with prevalent OA, incident OA, and progression to joint replacement. We assessed the specificity of OA association through comparison of associations with inflammatory joint diseases and with previous joint replacement.ResultsThe CRTAC1 protein showed the strongest association with prevalent knee OA (odds ratio [OR] 1.34 [95% confidence interval (95% CI) 1.27, 1.41]) and was associated with hip OA (OR 1.19 [95% CI 1.11, 1.28]). It predicted incident diagnosis of OA in the knee (hazard ratio [HR] 1.40 [95% CI 1.35, 1.46]) and hip (HR 1.25 [95% CI 1.19, 1.31]), as well as progression to joint replacement (HR 1.20 [95% CI 1.08, 1.33] for the knee and HR 1.22 [95% CI 1.08, 1.38] for the hip), while no association was found with inflammatory joint diseases. Individuals in the highest quintile of risk based on CRTAC1 level, age, sex, and body mass index had a 10‐fold risk of knee or hip OA within 5 years compared to those in the lowest quintile. Adding aggrecan core protein (ACAN) and neurocan core protein (NCAN) to the model improved the prediction of OA but not joint replacement. Furthermore, we replicated the association of CUB domain–containing protein 1 with prior joint replacement.ConclusionPlasma CRTAC1 is a specific biomarker for OA and a predictor of OA risk and progression to joint replacement. Adding ACAN and NCAN protein levels to the CRTAC1 model improved the prediction of OA.
Dorsal striatal hypoconnectivity predicts antipsychotic medication treatment response in first‐episode psychosis and unmedicated patients with schizophrenia
Authors: Nelson Eric A. , Kraguljac Nina V. , Maximo Jose O. , Armstrong William , Lahti Adrienne C. 
Published: October 2022

AbstractIntroductionThe dorsal striatum, comprised of the caudate and putamen, is implicated in the pathophysiology of psychosis spectrum disorders. Given the high concentration of dopamine receptors in the striatum, striatal dopamine imbalance is a likely cause in cortico‐striatal dysconnectivity. There is great interest in understanding the relationship between striatal abnormalities in psychosis and antipsychotic treatment response, but few studies have considered differential involvement of the caudate and putamen. This study's goals were twofold. First, identify patterns of dorsal striatal dysconnectivity for the caudate and putamen separately in patients with a psychosis spectrum disorder; second, determine if these dysconnectivity patterns were predictive of treatment response.MethodsUsing resting state functional connectivity, we evaluated dorsal striatal connectivity using separate bilateral caudate and putamen seed regions in two cohorts of subjects: a cohort of 71 medication‐naïve first episode psychosis patients and a cohort of 42 unmedicated patients with schizophrenia (along with matched controls). Patient and control connectivity maps were contrasted for each cohort. After receiving 6 weeks of risperidone treatment, patients’ clinical response was calculated. We used regression analyses to determine the relationship between baseline dysconnectivity and treatment response.ResultsThis dysconnectivity was also predictive of treatment response in both cohorts.DiscussionThese findings suggest that the caudate may be more of a driving factor than the putamen in early cortico‐striatal dysconnectivity.
The bioresorbable magnesium scaffold (Magmaris)—State of the art: From basic concept to clinical application
Authors: Rola Piotr , Włodarczak Szymon , Doroszko Adrian , Lesiak Maciej , Włodarczak Adrian 
Published: October 2022

AbstractSince its introduction to clinical practice, coronary artery stent implantation has become a crucial part of the therapy of coronary artery disease (CAD). Despite the undeniable evolution of percutaneous coronary revascularization procedures, drug‐eluting stent (DES) technology shows some limitations. To overcome these limitations bioresorbable vascular scaffolds (BRS) were designed as a vessel‐supporting technology allowing for anatomical and functional restoration of the vessel after the scaffold intended resorption. Various materials have been proposed as the basis of the scaffold backbone. In this narrative review, we present second‐generation magnesium‐alloy bioresorbable scaffold devices (Magmaris; Biotronik). Additionally, we discuss available preclinical and clinical data regarding this new magnesium BRS.
Milder presentation of autosomal dominant fatty acyl CoA reductase 1‐related syndrome: Report of the first Middle Eastern patient and review of the literature
Authors: Almuqbil Mohammed , AbuMelha Ahlam , Albokhari Daniah 
Published: October 2022

AbstractThe FAR1‐related phenotypes caused by the FAR1 gene encodes the peroxisomal protein fatty acyl‐CoA reductase 1 (FAR1), which is required to reduce fatty acids to fatty alcohols used to form ether‐linked alkyl bonds. Biallelic loss‐of‐function variants have been associated with severe psychomotor developmental delay, seizures, cataracts, growth retardation with microcephaly, and spasticity. However, heterozygous variants in FAR1 have been recently linked to a rare genetic disorder called cataracts, spastic paraparesis, and speech delay (CSPSD). Here, we present the first Middle Eastern patient with a de novo pathogenic heterozygous variant in FAR1 identified by exome sequencing (ES) analysis and a detailed overview of the reported clinical phenotypes and genotypes. Our patient represents the milder end of the clinical spectrum, with medication‐free seizures by the first year of life, proper speech and fine motor development, as well as an absence of other previously reported features such as learning difficulties, axial hypotonia, and joint contracture. In addition, she had developmental dysplasia of the hip (DDH) that failed medical management, as well as faltering growth. Our patient adds to the small number of patients recognized to date and expands the clinical spectrum to provide better clinical delineation, improve diagnosis, and develop precision medicine approaches for this disorder.
Aqueous Supercapacitors with Low Cost and High Voltage Enabled by Co‐Solute Crowding Effect of Electrolyte
Authors: Wang Chengshuai , Pu Yunxun , Feng Jianze , Xu Yongtai , Su Kailimai , Yang Bingjun , Lang Junwei , Tian Guangke 
Published: October 2022

AbstractDeveloping high‐voltage and environmentally friendly aqueous electrolytes have become a significant trend in supercapacitors (SCs). However, achieving this goal usually requires the use of “water‐in‐salt” (WIS) electrolytes, inevitably increasing manufacturing costs and sometimes posing problems such as environmental pollution. Here, we developed a water/organic solvent hybrid electrolyte (8 m NaClO4‐20 % H2O‐30 % ACN‐50 % PEG‐200) with low cost and high‐voltage capacity using the water‐miscible polymer polyethylene glycol (PEG) as a crowding agent to suppress water activity, and acetonitrile (ACN) as a co‐solvent to improve the ion transport properties. The synergistic advantages of the two co‐solvents allow SCs using this electrolyte to have a high operative voltage window of up to 2.6 V, currently the highest operating voltage for aqueous carbon‐based SCs, excellent capacity retention (over 11000 cycles) and high energy densities (31.2 Wh kg−1). This work provides a promising method for developing green and inexpensive high‐voltage window aqueous electrolytes.
BODIPY‐Equipped Benzo‐Crown‐Ethers as Fluorescent Sensors for pH Independent Detection of Sodium and Potassium Ions
Authors: Sprenger Tobias , Schwarze Thomas , Müller Holger , Sperlich Eric , Kelling Alexandra , Holdt Hans‐Jürgen , Paul Jérôme , Martos Riaño Vera , Nazaré Marc 
Published: October 2022

AbstractHerein, we report on fluorescent probes which enable the selective quantification of Na+ and K+ in water by fluorescence enhancement (FE) independent of the pH value. These fluorescent probes, so called fluoroionophores, consist of benzo‐crown‐ether derivatives as ionophores, a benzo‐15‐crown‐5 (cf. 5) or a benzo‐18‐crown‐6 (cf. 6), respectively, to selectively bind either Na+ or K+ and a 4,4‐difluoro‐1,3,5,7‐tetramethyl‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY) fluorophore. The fluoroionophore 5 shows a FE factor of 7.3 in the presence of 1000 mM Na+ and 6 of 4.7 upon addition of 250 mM K+ in an acidic environment. The dissociation constants (Kd) for 5+Na+ is 276 mM and for 6+K+ is 18 mM enabling the fluorometric determination of biological relevant Na+ or K+ levels. The fluorescence intensities of 5 and 6 were not impacted over a broad range of proton concentrations (pH stable from 3.5 to 9.5) and by the presence of other biologically relevant cations.
A retrospective analysis of Journal of Forecasting: From 1982 to 2019
Authors: Yu Dejian , Sheng Libo , Shi Shunshun 
Published: October 2022

AbstractThis research offers a thorough examination of Journal of Forecasting (JoF) from two angles. On the one hand, this research examines a total of 1403 publications indexed by Web of Science (WoS) from 1982 to 2019. Not only some fundamental statistics like the number of publications and citations each year, the most prolific countries/regions/authors, the highly cited countries/regions/authors, and papers are counted, but content analysis is also done to look at things like document co‐citation clusters and hot and emerging subjects. On the other hand, to illustrate the knowledge flow of JoF that underlies citation connections, this research, which is based on the citing papers of JoF publications, exposes the direction of JoF knowledge dissemination from Economics and Management (i.e., the categories where JoF belongs) to other categories. Moreover, a deeper investigation on semantic clustering of five representative categories is conducted to figure out what topics are the citing papers of JoF are most interested in and whether there is any relationship between the knowledge of these categories and the knowledge produced by JoF. The framework for journal evaluation presented in this research is novel and comprehensive. With this comprehensive perspective, we are able to look back on past accomplishments, identify historical patterns of knowledge spread, illustrate the current course of development, and partially predict future dynamics.
Trends of seasonal forage yield changes of triticale in the southern Great Plains of the United States
Authors: Kumssa Tadele T. , Anderson Joshua D. , Johnson James P. , Norton Shawn , Saha Malay C. , Trammell Michael A. , Rogers James K. , Butler Twain J. , Ma Xue‐Feng 
Published: October 2022

AbstractBackgroundThe focus of triticale breeding in the southern Great Plains of the United States has been to increase forage yield for autumn–winter seasons when most other forage species are dormant. This study aims to estimate the trends of seasonal yield changes over time.MethodsYield trials had been conducted in a randomized complete block design for up to two decades. Seasonal yield changes over time were estimated using linear regression analysis.ResultsThe analysis revealed a significant positive relation between autumn forage yield (relative to common checks) and calendar years when the trials were conducted. The estimated improvement of autumn forage yield was about 1.9% per year on medium and heavy soil at Ardmore, Oklahoma, and about 5.4% per year on light soil at Burneyville, Oklahoma. However, winter forage yield change was minimal and the spring forage yield increase was negative, although this decline was not significant. Total forage yield improvements were about 0.6% and 0.7% per year at Ardmore and Burneyville, respectively. Similar results were also observed when years of cultivars' introduction were used instead.ConclusionsThe results indicate a significant gain in autumn forage yield, but a minor gain in the total forage yield due to the yield tradeoff between the autumn and spring seasons.
What's data got to do with it? A scoping review of data used as evidence in policies promoting the health of Aboriginal and Torres Strait Islander children in the Northern Territory, Australia
Authors: Lloyd‐Johnsen Catherine , Eades Sandra , D'Aprano Anita , Goldfeld Sharon 
Published: October 2022

AbstractIssue addressedAccurate data on the health of Australia's First Nations peoples is critical in determining appropriate public health programs and establishing a baseline against which to measure progress. The effective translation of evidence into practice continues to be a challenge for Australian health departments and policymakers. The objective of this scoping review was to (i) determine the extent and range of policies relevant to the health and well‐being of Aboriginal and Torres Strait Islander children in the Northern Territory (NT); to (ii) identify what data is reported to be used as evidence to reconcile policy goals with outcomes, (iii) to describe issues acknowledged by policy makers relating to data availability and/or limitations, and to (iv) examine how principles of Indigenous inclusion and self‐determination are included in these policies.MethodsA search for current policy documents, strategic plans/initiatives or frameworks was conducted across Ovid Medline, PubMed, Informit, Scopus, in addition to a web‐based search for grey literature. Current policy documents for the period 2010‐2021 were included providing at least one of the goals or objectives were relevant to the health and well‐being of Australian Aboriginal and Torres Strait Islander children from the NT.ResultsThe search located 2610 unique citations. Full‐text screening was conducted on 85 documents, a total of 49 policy documents or strategic plans/frameworks were included in the final synthesis. The source of data being used as evidence was unclear or absent in 10 of the 49 (20.4%) identified policy documents. Limitations of the available data were mentioned to some extent, but detailed information on quality and completeness was largely absent. In mapping the key principles of working in Aboriginal and Torres Strait Islander health contexts, only two policies articulated the need for information sharing and data governance.ConclusionsThis review underscores the importance of providing clear information about which data is being used to inform policy decisions so that they may be evaluated and critiqued in meaningful ways that ensure decision makers are accountable.So what?Specific data items and/or indicators should be explicitly referenced as evidence used in the development of policies promoting the health of Aboriginal and Torres Strait Islander children and their communities from the outset so that evaluation is clear and policy makers are held accountable.
Preoperative sonographic sliding sign for prediction of intra‐abdominal adhesions before repeat cesarean delivery
Authors: Charernjiratragul Kla , Suntharasaj Thitima , Pranpanus Savitree , Chanwadi Suthiraphorn , Kwankaew Noppasin , Petpichetchian Chusana 
Published: October 2022

AbstractObjectiveTo evaluate the usefulness of the uterine sliding sign for predicting intra‐abdominal adhesions in women undergoing repeat cesarean section (CS) and the association of the sliding sign with other operative and neonatal outcomes.MethodsA prospective cohort study was conducted among pregnant women with at least one previous CS. Transabdominal ultrasonography was performed and classified as a positive or negative sliding sign. Surgeons blinded to the sonographic results assessed intra‐abdominal adhesions. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated. Operative and neonatal outcomes of the positive and negative sliding sign groups were compared. Factors associated with intraoperative adhesions were also analyzed.ResultsA total of 380 women were recruited. The sensitivity and specificity of the uterine sliding sign to detect moderate‐to‐thick adhesions were 60.6% and 91.9%, respectively. A negative sliding sign was significantly associated with a higher incidence of adhesions, longer skin‐to‐delivery time, longer total operative time, and lower 5‐min APGAR score in newborns. A negative sliding sign and history of two or more previous CS were significant predictors of moderate‐to‐thick adhesions.ConclusionThe uterine sliding sign is an independent predictor of intraoperative adhesions, with acceptable sensitivity and high specificity and negative predictive value.
Metabolite profiling of human‐originated Lachnospiraceae at the strain level
Authors: Abdugheni Rashidin , Wang Wen‐Zhao , Wang Yu‐Jing , Du Meng‐Xuan , Liu Feng‐Lan , Zhou Nan , Jiang Cheng‐Ying , Wang Chang‐Yu , Wu Linhuan , Ma Juncai , Liu Chang , Liu Shuang‐Jiang 
Published: October 2022

AbstractThe human gastrointestinal (GI) tract harbors diverse microbes, and the family Lachnospiraceae is one of the most abundant and widely occurring bacterial groups in the human GI tract. Beneficial and adverse effects of the Lachnospiraceae on host health were reported, but the diversities at species/strain levels as well as their metabolites of Lachnospiraceae have been, so far, not well documented. In the present study, we report on the collection of 77 human‐originated Lachnospiraceae species (please refer hLchsp, https://hgmb.nmdc.cn/subject/lachnospiraceae) and the in vitro metabolite profiles of 110 Lachnospiraceae strains (https://hgmb.nmdc.cn/subject/lachnospiraceae/metabolites). The Lachnospiraceae strains in hLchsp produced 242 metabolites of 17 categories. The larger categories were alcohols (89), ketones (35), pyrazines (29), short (C2–C5), and long (C > 5) chain acids (31), phenols (14), aldehydes (14), and other 30 compounds. Among them, 22 metabolites were aromatic compounds. The well‐known beneficial gut microbial metabolite, butyric acid, was generally produced by many Lachnospiraceae strains, and Agathobacter rectalis strain Lach‐101 and Coprococcus comes strain NSJ‐173 were the top 2 butyric acid producers, as 331.5 and 310.9 mg/L of butyric acids were produced in vitro, respectively. Further analysis of the publicly available cohort‐based volatile‐metabolomic data sets of human feces revealed that over 30% of the prevailing volatile metabolites were covered by Lachnospiraceae metabolites identified in this study. This study provides Lachnospiraceae strain resources together with their metabolic profiles for future studies on host–microbe interactions and developments of novel probiotics or biotherapies.
Recent advances in interface engineering strategy for highly‐efficient electrocatalytic water splitting
Authors: Du Yunmei , Li Bin , Xu Guangrui , Wang Lei 
Published: October 2022

AbstractThe hydrogen energy generated by the electrocatalytic water splitting reaction has been established as a renewable and clean energy carrier with ultra‐high energy density, which can well make up for shortcomings of conventional renewable energy sources, such as geographical limitations, climatic dependence, and energy wastage. Notably, the introduction of electrocatalysts can enhance the efficiency of the water splitting process to generate hydrogen. Particularly, the heterostructure electrocatalysts constructed by coupling multiple components (or phases) have emerged as the most promising option for water splitting due to the well‐known electronic and synergistic effects. The existing reviews on interface engineering for electrocatalyst design mostly focus on the relationship between the heterostructures and specific electrocatalytic reactions. However, a comprehensive overview of the integration of model building, directional synthesis, and electrocatalytic mechanism has been rarely reported. To this end, in this review, the development of heterostructure catalysts is systematically introduced from the perspective of interface classification, interface growth and synthesis, and regulation of electrocatalytic performance based on the interfacial microenvironment (bonding, electronic configuration, lattice strain, etc.), thereby offering useful insights on the design and construction of interfacial models. Besides, combined with the current development and applications of interface engineering strategies, the challenges of future heterostructure catalysts are discussed and relevant solutions are proposed. Overall, this review can serve as a useful theoretical reference for the integration of interfacial model building, directional synthesis, and electrocatalytic mechanism, which can further promote the development of hydrogen production technologies with low energy consumption and high yield.image
Phosphorylase phosphatase and flash activation of skeletal muscle glycogen phosphorylase—A tribute to Edmond H. Fischer
Authors: Brautigan David L. 
Published: October 2022

AbstractGlycogen is a polymerized form of glucose that serves as an energy reserve in all types of organisms. In animals glycogen synthesis and degradation, especially in liver and skeletal muscle, are regulated by hormonal and physiological signals that reciprocally control the opposing activities of glycogen synthase and glycogen phosphorylase. These enzymes are under allosteric control by binding of metabolites (e.g., ATP, AMP, G6P) and covalent control by reversible phosphorylation by kinase and phosphatase all assembled together on glycogen. More than 50 years ago Edmond Fischer and colleagues showed “flash activation” of phosphorylase in glycogen particles. This involved transient and extensive inhibition of protein phosphatase but even today the phenomenon is not understood. Phosphatase regulation is known to rely on regulatory subunits including glycogen binding subunits that serve as scaffolds, binding catalytic subunit, glycogen, and substrates. This tribute article to Edmond Fischer highlights his thoughts and ideas about the transient inhibition of phosphorylase phosphatase during flash activation of phosphorylase and speculates that phosphatase regulation in glycogen particles might involve a/b hybrids of phosphorylase.