bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Alzheimer and Lewy Body Disease Pathologies on Brain Metabolism
Authors: Lee Young‐gun , Jeon Seun , Park Mincheol , Kang Sung Woo , Yoon So Hoon , Baik Kyoungwon , Lee Phil Hyu , Sohn Young Ho , Ye Byoung Seok ,   the Alzheimer's Disease Neuroimaging Initiative
Published: March 2022

ObjectiveThis study aimed to determine the pattern of 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) related to postmortem Lewy body disease (LBD) pathology in clinical Alzheimer disease (AD).MethodsFDG‐PET scans were analyzed in 62 autopsy‐confirmed patients and 110 controls in the Alzheimer's Disease Neuroimaging Initiative. Based on neuropathologic evaluations on Braak stage for neurofibrillary tangle, Consortium to Establish a Registry for AD score for neuritic plaque, and Lewy‐related pathology, subjects were classified into AD(−)/LBD(−), AD(−)/LBD(+), AD(+)/LBD(−), and AD(+)/LBD(+) groups. The association between postmortem LBD and AD pathologies and antemortem brain metabolism was evaluated.ResultsAD and LBD pathologies had significant interaction effects to decrease metabolism in the cerebellar vermis, bilateral caudate, putamen, basal frontal cortex, and anterior cingulate cortex in addition to the left side of the entorhinal cortex and amygdala, and significant interaction effects to increase metabolism in the bilateral parietal and occipital cortices. LBD pathology was associated with hypermetabolism in the cerebellar vermis, bilateral putamen, anterior cingulate cortex, and basal frontal cortex, corresponding to the Lewy body‐related hypermetabolic patterns. AD pathology was associated with hypometabolism in the bilateral hippocampus, entorhinal cortex, and posterior cingulate cortex regardless of LBD pathology, whereas LBD pathology was associated with hypermetabolism in the bilateral putamen and anterior cingulate cortex regardless of AD pathology.InterpretationPostmortem LBD and AD pathologies had significant interaction effects on the antemortem brain metabolism in clinical AD patients. Specific metabolic patterns related to AD and LBD pathologies could be elucidated when simultaneously considering the two pathologies. ANN NEUROL 2022;91:853–863
EPDM‐g‐MAH toughened bio‐based polyamide 56 to prepare thermoplastic polyamide elastomer and the performance characterization
Authors: Xu Yuhan , Zhao Chenyu , Guo Zhiyuan , Dong Wenjie , Liu Xiucai , Guo Weihong 
Published: March 2022

AbstractPolyamide is an engineering plastic, which has been widely used in industry and life. Polyamide 56, as a green and environmentally friendly bio‐based product, is gradually replacing traditional petroleum‐based products. However, in terms of auto parts, communication equipment, and mechanical products, a single polyamide monomer is difficult to meet the end‐use standard. EPDM‐g‐MAH (ethylene propylene diene monomer grafted with maleic anhydride) is melt blended with bio‐based polyamide 56 (PA56) in a twin‐screw extruder to obtain polyamide elastomers with different formulations. Subsequently, its morphology and structure, thermodynamic properties, crystallinity, and mechanical properties were analyzed. The test results show that the composites containing 10% EPDM‐g‐MAH have better impact resistance and thermal properties in the range of adding 0‑20 wt% EPDM‐g‐MAH. In the fracture morphology analysis, it is found that the interface between the rubber phase and the polyamide phase fused well, and the elastomer showed the ductile fracture.
The first complete mitochondrial genome of Dufouriellini (Hemiptera: Anthocoridae) and implications for its phylogenetic position
Authors: Zhang Danli , Xu Le , Wang Shujing , Liang Jingyu , Li Min , Zhang Haiguang 
Published: March 2022

AbstractThe mitochondrial genome (mitogenome) is extensively used to better understand the phylogenetic relationships within the family level, but there are still limited representations at the tribe level of Anthocoridae. Here we describe the first complete mitogenome of Dufouriellini. The mitogenome of Cardiastethus sp. is 15,209 bp in size, containing 13 typical protein‐coding genes, 22 transfer RNAs, 2 ribosomal RNAs, and a control region. All genes are arranged in the same gene order as the most other known cimicomorphan mitogenomes. The phylogenetic relationships based on mitogenomes using Bayesian inference and maximum likelihood methods show that Dufouriellini is sister to Anthocorini, and then both of them together form sister group with Oriini. The monophyly of each superfamily of Cimicomorpha is generally well supported. Reduvioidea is basal within Cimicomorpha. The topology of the remaining superfamily is as follows: (Miroidea + (Cimicoidea + (Velocipedoidea + Nabioidea))). This study will help to enhance our understanding of mitochondrial genomic evolution and phylogenetic relationships in the tribe level of Anthocoridae and also superfamily level of Cimicomorpha.
Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells
Authors: Sacco Sarah A. , Tuckowski Angela M. , Trenary Irina , Kraft Lauren , Betenbaugh Michael J. , Young Jamey D. , Smith Kevin D. 
Published: March 2022

AbstractThe glutamine synthetase (GS) expression system is commonly used to ensure stable transgene integration and amplification in Chinese hamster ovary (CHO) host lines. Transfected cell populations are typically grown in the presence of the GS inhibitor, methionine sulfoximine (MSX), to further select for increased transgene copy number. However, high levels of GS activity produce excess glutamine. We hypothesized that attenuating the GS promoter while keeping the strong IgG promoter on the GS‐IgG expression vector would result in a more efficient cellular metabolic phenotype. Herein, we characterized CHO cell lines expressing GS from either an attenuated promoter or an SV40 promoter and selected with/without MSX. CHO cells with the attenuated GS promoter had higher IgG specific productivity and lower glutamine production compared to cells with SV40‐driven GS expression. Selection with MSX increased both specific productivity and glutamine production, regardless of GS promoter strength. 13C metabolic flux analysis (MFA) was performed to further assess metabolic differences between these cell lines. Interestingly, central carbon metabolism was unaltered by the attenuated GS promoter while the fate of glutamate and glutamine varied depending on promoter strength and selection conditions. This study highlights the ability to optimize the GS expression system to improve IgG production and reduce wasteful glutamine overflow, without significantly altering central metabolism. Additionally, a detailed supplementary analysis of two “lactate runaway” reactors provides insight into the poorly understood phenomenon of excess lactate production by some CHO cell cultures.
Pursuing sustainability advantage: The dynamic capabilities of born sustainable firms
Authors: Knoppen Desirée , Knight Louise 
Published: March 2022

Abstract‘Born sustainable firms’ (BSFs) — firms founded with an explicit strategic intent to operate in a sustainable manner play an important role in the sustainability transition and represent a significant but underutilized research site. Adopting the dynamic capabilities (DC) perspective, this paper explores BSFs' pursuit of their environmental and social goals. Having first assessed and confirmed its relevance to the BSF context, a high level framework of DC processes is operationalized. Through a dialogic approach, comparing the literature and empirical material from 12 BSFs from a wide range of sectors and locations, an in‐depth picture of 28 processes underlying sensing, seizing and transforming meta‐capabilities emerges. All but one of the detailed processes can be linked to prior research and are specific, though not unique, to BSF. Whilst the operationalized framework of DC processes in the BSF context extends prior research, the established notion of competitive advantage — framing organizational goals and impact in terms of financial outcomes and strategic performance relative to rivals — is problematic in this context. We therefore reconceptualize BSF's organizational goals and impact in terms of ‘sustainability advantage’, that is, maximization of environmental and social performance within the constraint of economic viability. In addition, we identify two key dimensions of advantage: time horizon, which ranges from immediate to longer term impact, and scope, which ranges from organization‐centred to system‐wide impact. The findings have clear implications not only for sustainable entrepreneurship but also for incumbent firms moving towards genuine sustainability.
A review study on the investigation of the effects of using robots in education on metacognitive behaviors
Authors: Özkan Sibel B. , Toz Metin 
Published: March 2022

AbstractIn today's technology, robots are now involved in all aspects of life. Therefore, it is inconceivable that robots will not affect the field of education either. In this study, the use of robots in education has been explicitly discussed in terms of the development of metacognitive abilities. For this purpose, literature studies have been conducted both on the development of metacognitive skills and on how robots are used in education. According to the results obtained, although robots have been used in many fields of education, they have not been used primarily in the field of developing metacognitive skills. From this point of view, in this study, some research questions and suggestions for the application of metacognitive models through robots and, therefore, the use of robots to improve metacognitive skills are presented to the researchers. It is expected that it will benefit researchers related to this question and the proposed topic to direct their research and help close the lack of research in this area.
Prostate cancer incidence and survival in relation to prostate cancer as second cancer in relatives
Authors: Zheng Guoqiao , Sundquist Jan , Sundquist Kristina , Ji Jianguang 
Published: March 2022

AbstractObjectivesTo investigate if the risk of prostate cancer (PC) differs based on the order of primary PC diagnosed in first‐degree relatives (FDRs) given possibly different risk factors for PC as first primary cancer (PCa‐1) and second primary cancer (PCa‐2).Subjects and MethodsIn this Swedish nationwide cohort, PC diagnosis was followed for among 149,985 men with one FDR affected by PCa‐1, 10,972 with one FDR affected by PCa‐2 and 2,896,561 without any FDRs affected by cancer in a maximum of 57 years. PC patients were further followed for death due to PC since diagnosis. Relative risk (RR) of PC was estimated with Poisson regression and hazard ratio (HR) with Cox proportional hazard model.ResultsCompared to men without any FDRs affected by cancer, the RRs of PC in men with one FDR affected by PCa‐1 and PCa‐2 were 2.12 (95% confidence interval [CI]: 2.07–2.17) and 1.69 (1.54–1.85), respectively. The risk in men with one FDR affected by PCa‐2 was significantly lower than those with one FDR affected by PCa‐1 after additionally adjusting for family relationship (father‐son and brothers) and age at diagnosis of PC in FDR (RR PCa‐2 vs PCa‐1, 0.85, 95% CI, 0.78–0.94). PC patients with a family history of PCa‐2 were more likely to be detected at late‐stage and less likely to be diagnosed by screening, compared to those with a family history of PCa‐1. Patients whose PC was diagnosed after the diagnosis of PCa‐1 in FDRs had a better survival than those without a family history of cancer (HR, 0.88, 95% CI, 0.80–0.97), but no such association was observed among patients with a family history of PCa‐2.ConclusionOur study indicates a discrepancy between PC risks associated with a family history of PCa‐1 and PC‐2 and the reason behind it may be multifactorial.
BRCA1/2 testing among young women with breast cancer in Massachusetts, 2010–2013: An observational study using state cancer registry and All‐Payer claims data
Authors: Pace Lydia E. , Ayanian John Z. , Wolf Robert E. , Knowlton Richard , Gershman Susan T. , Hawkins Summer Sherburne , Keating Nancy L. 
Published: March 2022

AbstractBackgroundTesting for BRCA1/2 pathogenic variants is recommended for women aged ≤45 years with breast cancer. Some studies have found racial/ethnic and socioeconomic disparities in testing. We linked Massachusetts' All‐Payer Claims Database with Massachusetts Cancer Registry data to assess factors associated with BRCA1/2 testing among young women with breast cancer in Massachusetts, a state with high levels of access to care and equitable insurance coverage of breast cancer gene (BRCA) testing.MethodsWe identified breast cancer diagnoses in the Massachusetts Cancer Registry from 2010 to 2013 and linked registry data with Massachusetts All‐Payer Claims Data from 2010 to 2014 among women aged ≤45 years with private insurance or Medicaid. We used multivariable logistic regression to examine factors associated with BRCA1/2 testing within 6 months of diagnosis.ResultsThe study population included 2424 women; 80.3% were identified as non‐Hispanic White, 6.4% non‐Hispanic Black, and 6.3% Hispanic. Overall, 54.9% received BRCA1/2 testing within 6 months of breast cancer diagnosis. In adjusted analyses, non‐Hispanic Black women had less than half the odds of testing compared with non‐Hispanic White women (adjusted odds ratio [OR] = 0.45, 95% CI = 0.31, 0.64). Medicaid‐insured women had half the odds of testing compared with privately‐insured women (OR = 0.51, 95% CI = 0.41, 0.63). Living in lower‐income areas was also associated with lower odds of testing. Having an academically‐affiliated oncology clinician was not associated with testing.ConclusionSocioeconomic and racial/ethnic disparities exist in BRCA1/2 testing among women with breast cancer in Massachusetts, despite equitable insurance coverage of testing. Further research should examine whether disparities have persisted with growing testing awareness and availability over time.
Stroke after transcatheter aortic valve replacement: A severe complication with low predictability
Authors: Eschenbach Lena K. , Erlebach Magdalena , Deutsch Marcus‐André , Ruge Hendrik , Bleiziffer Sabine , Holzer Lisa , Krane Markus , Voss Stephanie , Lange Ruediger , Burri Melchior 
Published: March 2022

AbstractObjectivesWe aimed to describe stroke and transient ischemic attacks (TIAs) after transcatheter aortic valve replacement (TAVR) and to identify associated risk factors.BackgroundStroke/TIA after TAVR is a major complication.MethodsA total of 1919 concomitant patients underwent TAVR in a single center from 2007 to 2017. Pre‐, intra‐, and postprocedural data were collected prospectively in a database and analyzed retrospectively. Stroke and TIA were documented according to the Valve Academic Research Consortium‐II criteria. Logistic regression was used to determine risk factors for stroke after TAVR.ResultsMean age was 79.5 ± 6.8 years, mean logistic EuroScore was 17.6% ± 12.8%, and 51.8% (n = 994) of the patients were female. Stroke/TIA occurred in 76 patients (3.9%), 1.9% were disabling, and 1.6% nondisabling. The predominant type of stroke were territorial ischemic lesions (82.4%), with primary bleeding in 4.4% and border zone infarctions in 4.4%. Left‐sided lesions were more common (45.6% left sided vs. 25% right sided) and 13.2% of the lesions were bilateral (4.4% no finding and 11.8% missing data). In multivariate logistic regression, prior stroke (odds ratio [OR] = 1.83, p = 0.046) and initial experience (first 300 TAVR implanted at our center) were identified as independent risk factors for stroke/TIA during the first 30 days (OR = 1.95, p = 0.045). Overall, the occurrence of stroke had a highly significant impact on a 30‐day mortality (13.2% vs. 4.9% in patients without stroke (p = 0.005).ConclusionStroke within the first 30 days after TAVR severely impairs 30‐day survival. We identified prior stroke and initial experience as significant independent risk factors for the occurrence of stroke after TAVR.
Volume of contrast to creatinine clearance ratio predicts early mortality and AKI after TAVI
Authors: Venturi Gabriele , Scarsini Roberto , Pighi Michele , Kotronias Rafail A. , Piccoli Anna , Lunardi Mattia , Del Sole Paolo , Mainardi Andrea , Gambaro Alessia , Tavella Domenico , De Maria Giovanni L. , Kharbanda Rajesh , Pesarini Gabriele , Banning Adrian , Ribichini Flavio 
Published: March 2022

AbstractThe volume of contrast to creatinine clearance ratio (CV/CrCl) is a useful indicator of the risk of acute kidney injury (AKI) in patients undergoing percutaneous interventional procedures. Association between CV/CrCl and adverse outcome after transcatheter aortic valve implantation (TAVI) was suggested but it is not well established. A large retrospective multicenter cohort of 1381 patients treated with TAVI was analyzed to assess the association between CV/CrCl and the risk of AKI and mortality at 90 days and 1 year after TAVI. Patients receiving renal replacement therapy at the time of TAVI were excluded. CV/CrCl ≥ 2.2 was associated with the risk of AKI and 90 days mortality after TAVI after adjustment for age, sex, diabetes, baseline left ventricular function, baseline chronic kidney disease (CKD), previous myocardial infarction and peripheral vascular disease (hazard ratio [HR]: 1.16, 95% confidence interval [CI]: 1.09–1.22, p < 0.0001). Importantly, CV/CrCl was associated with the adverse outcome independently from the presence of baseline CKD (p for interaction = 0.22). CV/CrCl was independently associated with the individual components of the composite primary outcome including AKI (odds ratio: 1.18, 95% CI: 1.08–1.28, p < 0.0001) and 90 days mortality (HR: 1.90, 95% CI: 1.01–3.60, p = 0.047) after TAVI. AKI (HR: 1.94, 95% CI: 1.21–3.11, p = 0.006) but not CV/CrCl was associated with the risk of 1‐year mortality after TAVI. CV/CrCl is associated with excess renal damage and early mortality after TAVI. Procedural strategies to minimize the CV/CrCl during TAVI may improve early clinical outcomes in patients undergoing TAVI.
Device entrapment during percutaneous coronary intervention
Authors: Sanz‐Sánchez Jorge , Mashayekhi Kambis , Agostoni Pierfrancesco , Egred Mohaned , Avran Alexandre , Kalyanasundaram Arun , Garbo Roberto , Colombo Antonio , Regazzoli Damiano , Reimers Bernhard , Brilakis Emmanouil S. , Gasparini Gabriele L. 
Published: March 2022

AbstractIntroductionDevice entrapment is a life‐threatening complication during percutaneous coronary intervention (PCI). However, the success for its management is predominantly based on operator experience with limited available guidance in the published literature.MethodsA systematic review was performed on December 2021; we searched PubMed for articles on device entrapment during PCI. In addition, backward snowballing (i.e., review of references from identified articles and pertinent reviews) was employed.ResultsA total of 4209 articles were retrieved, of which 150 studies were included in the synthesis of the data. A methodical algorithmic approach to prevention and management of device entrapment can help to optimize outcomes. The recommended sequence of steps are as follows: (a) pulling, (b) trapping, (c) snaring, (d) plaque modification, (e) telescoping, and (f) surgery.ConclusionsIn‐depth knowledge of the techniques and necessary tools can help optimize the likelihood of successful equipment retrieval and minimization of complications.
Eye movement desensitization and reprocessing as a therapy for rape victims: A case series
Authors: Rostaminejad Akbar , Alishapour Maryam , Jahanfar Abdolhadi , Fereidouni Zhila , Behnammoghadam Mohammad 
Published: March 2022

AbstractA case series was conducted on three rape victims who were hospitalized with a diagnosis of major depressive disorder (MDD). Eye movement desensitization and reprocessing (EMDR) was employed to reduce their risk of suicide or suicidal ideations. EMDR can be an effective treatment to reduce the level of suicidal ideation in rape victims.
A case report of a teenager with hepatitis B surface antigen‐positive multifocal hepatocellular carcinoma in a noncirrhotic liver
Authors: Danso Kwadwo Apeadu , Akuaku Rosemary Sefakor , Taylor Rebekah Ruth , Amoako Emmanuella , Ulzen‐Appiah Kofi , Jimah Bashiru Babatunde , Tagoe Lily Gloria 
Published: March 2022

AbstractHepatitis B virus is a known carcinogen for hepatocellular carcinoma, which is rare in the pediatric population. We report a 13‐year‐old patient with hepatitis B surface antigen‐positive multifocal hepatocellular carcinoma in a noncirrhotic liver. Her APRI score was 0.24. Her BCLC stage was C, and her caregiver opted for palliative care.
Acquired double pylorus presenting as a gastrointestinal bleeding
Authors: Laabidi Sarra , Ben Mohamed Asma , Khsiba Amal , Yakoubi Manel , Mahmoudi Moufida , Medhioub Mouna , Hamzaoui Lamine , Azouz Mohamed Mssadak 
Published: March 2022

AbstractWe present the case of a 65‐year‐old man without a past medical history who was admitted for gastrointestinal bleeding. The case shows an acquired double pylorus due to probable pre pyloric ulcer.
Designing Nanosheet Heterostructures of CuO Grown on Bi2MoO6 as a Photoelectrochemical Biosensor for Detecting Alpha‐Fetoprotein
Authors: Zhao Mingxia , Yang Liqin , Zhao Jun , Jiang Junbing , Wang Zheng , Wang Yuman , Cai Zhenyu , Zhao Zhiju 
Published: March 2022

AbstractBi2MoO6 (BM) was modified with various amounts of CuO. Photoelectrochemical (PEC) tests of the resulting CuO‐doped BM materials showed improved PEC performance. The best PEC performance was obtained for BM containing 5 wt % of CuO. CuO/BM‐5 % was then used as an active material for an Alpha‐fetoprotein (AFP) PEC biosensor. A PEC biosensor‐based CuO/BM‐5 % detected AFP linearly from 0.01–1200 ng ⋅ L−1 with a detection limit of 0.005 ng ⋅ L−1. The photoelectron potential of the CuO/BM‐5 % heterojunction reduced the electron/hole recombination, which explains the excellent PEC performance of this material.
Experimental design optimization and isotherm modeling for removal of copper(II) by calcium‐terephthalate MOF synthesized from recycled PET waste
Authors: Zolgharnein Javad , Dermanaki Farahani Saeideh 
Published: March 2022

AbstractIn this research, a calcium‐terephthalate metal–organic framework ([Ca(BDC)(H2O)3]) was synthesized by a new high yield solvothermal method as an efficient adsorbent. Terephthalate ligand recovered from polyethylene terephthalate (PET) waste was used as a precursor in the synthesis process. The adsorption ability of this compound to remove copper(II) from aqueous solutions was investigated. Experimental designs involving Plackett–Burman and Doehlert designs were used for the optimization of the adsorption process. Plackett–Burman design was used for screening the effective factors such as pH, adsorbent dosage, and initial concentration of Cu(II). Running Doehlert design (DD) as an optimization approach led to find a model for relation between response and effective factors and maximized uptake capacity (q) of Cu(II) (q = 351.3 mg˖g−1) under optimum conditions (pH = 5, adsorbent dosage = 1.50 mg and initial concentration of Cu(II) = 150 mgL−1). Infrared spectroscopy (FTIR), X‐ray diffraction (XRD), energy‐dispersive X‐ray (EDX), and field‐emission scanning electron microscopy (FESEM) analyses were applied to investigate the chemical and crystal structure of [Ca(BDC)(H2O)3]. Furthermore, kinetics, isotherms, thermodynamics, and desorption studies are complementary divisions of this research.