bluuebunny/crossref_metadata_2025_split huggingface dataset:
A network-based analysis for evaluating conditional covariance estimates
Authors: Scozzari Andrea , Drago Carlo 
Published: March 2022

Abstract
Modeling and forecasting of dynamically varying covariances have received much attention in the literature. The two most widely used conditional covariances and correlations models are the BEKK and the DCC ones. In this paper, we advance a new method based on Network analysis and a new targeting approach for both the two above models with the aim of better estimate covariance matrices associated with financial time series. Our approach is based on specific groups of highly correlated assets in a financial market, and assuming that these relationships remain unaltered at least in the long run. Based on the estimated parameters, we evaluate our targeting method on simulated series by referring to two well-known loss functions introduced in the literature. Furthermore we find and analyze all the maximal cliques in correlation graphs to evaluate the effectiveness of our method. Results from an empirical case study are encouraging, mainly when the number of assets is not large.
Is a 6-month Treatment for Isoniazid-resistant Tuberculosis Effective?
Authors: Kulizhskaya A. I. , Gurieva T. I. , Nikishova E. I. , Eliseev P. I. , Perkhin D. V. , Maryandyshev А. O. 
Published: March 2022

The objective: to compare treatment efficacy and relapse rates in patients with isoniazid-resistant tuberculosis treated with 9- and 6-month courses of chemotherapy.Subjects and Methods. A retrospective cohort study was conducted. The period from 2010 to 2015 was evaluated. The cases of tuberculosis registered on the territory of Arkhangelsk Region were studied. In 2010-2013, all patients with isoniazid-resistant tuberculosis (n = 130) in the region received a 9-month course of treatment. From 2014 to 2015, the duration of treatment for isoniazid-resistant tuberculosis in the region was reduced from 9 to 6 months. The patients (n = 54) received short-course treatment: aminoglycoside or polypeptide (2 months), rifampicin, pyrazinamide, fluoroquinolone, and ethambutol.There was no statistically significant difference in treatment outcomes of isoniazid-resistant tuberculosis between two regimens: The outcome of effective treatment made 76.2% for the 9-month regimen and 74.1% for the 6-month regimen. The relapse rate per 100 person-years was 0.7 (95% CI 0.1-1.9) for the 9-month regimen and 1.9 (95% CI 0.2-6.7) for the 6-month regimen. This study confirmed the need to decrease the duration of treatment for isoniazid-resistant tuberculosis to 6 months.
Ninety Years of Pentamidine: The Development and Applications of
Pentamidine and its Analogs
Authors: Zhang Bo , Jin Yushan , Zhang Lei , Wang Hongshuang , Wang Xiaohui 
Published: March 2022

Abstract:
Pentamidine, an FDA-approved human drug for many protozoal infections,
was initially synthesized in the late 1930s and first reported to be curative for parasitosis
in the 1940s. After ninety years of sometimes quiet growth, pentamidine and its derivatives
have gone far beyond antibacterial agents, including but not limited to the ligands
of DNA minor groove, modulators of PPIs (protein-protein interactions) of the transmembrane
domain 5 of lateral membrane protein 1, and the blockers of the SARS-CoV-2 3a
channel. This mini-review highlights the development and applications of pentamidine
and its analogs, aiming to provide insights for further developing pentamidine derivatives
in the following decades.
Thiophene Ring-Opening Reactions V. Expedient Synthesis of 1,3,4-
Thiadiazoline-Sulfanyl[1,3]thiazin-4-one Hybrids
Authors: Jarrar Abdullah K. , El-Abadelah Mustafa M. , Sabri Salim S. , Zahra Jalal A. , Hamdan Mohammad S. 
Published: March 2022

Abstract:
The preparation of 6-chloro-5-nitrothieno[3,2-e][1,3]thiazin-4-one incorporating 2-(Nmorpholinyl)
moiety is achieved via a conventional route. Interaction of the latter substrate with a set
of N'-(aryl) benzothiohydrazides 1a-f, in the presence of triethylamine, led to a thiophene ring-opening
process with the consequent generation of the respective thiolate salts 8a-f. Alkylation of the latter,
using methyl iodide or allyl chloride, generated the respective novel 1,3,4-thiadiazoline–6-sulfanyl-1,3-
thiazin-4-one hybrids, the structures of which were verified by HRMS and NMR spectral data.
†Dedicated to the memory of our friend and advisor Professor Dr. Wolfgang Voelter.
Idiopathic Nephrotic Syndrome in Pediatrics: An Up-to-date
Authors: Simões e Silva Ana Cristina , da Silva Filha Roberta , Burini Kassia , Pires Laura Gregório , Brant Pinheiro Sérgio Veloso 
Published: March 2022

Background:Idiopathic or Primary Nephrotic Syndrome (INS) is a common glomerular disease in pediatric population, characterized by proteinuria, edema and hypoalbuminemia with var-iable findings in renal histopathology.Objective:This review aims to summarize current data on the etiopathogenesis diagnosis, protocols of treatment and potential therapeutic advances in INS.Methods:This narrative review searched for articles on histopathology, physiopathology, genetic causes, diagnosis and treatment of INS in pediatric patients. The databases evaluated were PubMed and Scopus.Results:INS is caused by an alteration in the permeability of the glomerular filtration barrier with unknown etiology. There are several gaps in the etiopathogenesis, response to treatment and clinical course of INS that justify further investigation. Novel advances include the recent understanding of the role of podocytes in INS and the identification of genes associated with the disease. The role of immune system cells and molecules has also been investigated. The diagnosis relies on clinical find-ings, laboratory exams and renal histology for selected cases. The treatment is primarily based on steroids administration. In case of failure, other medications should be tried. Recent studies have al-so searched for novel biomarkers for diagnosis and alternative therapeutic approaches.Conclusion:The therapeutic response to corticosteroids still remains the main predictive factor for the prognosis of the disease. Genetic and pharmacogenomics tools may allow the identification of cases not responsive to immunosuppressive medications.
Domain-Specific Sedentary Behaviour and Health-Related Quality of Life
by Age among Japanese Living in Malaysia
Authors: Izawa Kazuhiro P. , Oka Koichiro 
Published: March 2022

Background:
Recently, the number of Japanese people living in Asia has increased. A pre-vious study suggested that obesity and overweight are growing health problems both in Malaysia and worldwide that result from lifestyle changes such as a decrease in physical activity, an increase in sedentary behaviour, and poor eating habits.

Objective:
The purpose of the present study was to investigate the effects of differences in social de-mographic factors and domain-specific sedentary behaviour and health-related quality of life by age in Japanese living overseas.

Methods:
We surveyed 109 participants by self-entry questionnaire for social demographic factors and domain-specific sedentary behaviour by life scenario and by Short Form-36 (SF-36) for health-related quality of life. The subjects were divided into the ≥65 years group and <65 years group.

Results:
Significant differences were noted in age, employment, alcohol intake, and marital status be-tween the groups, whereas none were noted for transportation, driving, television viewing, and smartphone/personal computer use. Work time and total sitting time of sedentary behaviour were higher, and leisure-time activity and SF-36 Mental Component Score for health-related quality of life were lower in the <65 years group.

Conclusion:
By assessing differences in social demographic factors and discouraging sedentary be-haviour, sitting time in overseas-dwelling Japanese residents may be reduced, and effective strategies to improve health-related quality of life can be developed to combat such behaviour.
Development of Fluorescently Labeled Self-Emulsifying Drug Delivery
Systems (SEDDS) for Prolonged Stability, In Vitro Sustained Release, and
Cellular Uptake
Authors: Malkawi Ahmad Saleh , Haddad Razan , Malkawi Azhar , Alrabadi Nasr 
Published: March 2022

Aim:
In this study, four fluorescein hydrophobic ionic complexes were formed with the
cationic polymers Eudragit RS, Eudragit RL, Eudragit E, and polyethyleneimine (PEI) to provide
fluorescein sustained release, sustained cellular uptake, and stability.

Methods:
Complexes were loaded in a self-emulsifying drug delivery system (SEDDS) composed
of 40% Tween 80, 20% Kolliphor EL, 15% 2-n-Octyl-1-dodecanol, and 25% dipropylene glycol.
SEDDS were investigated regarding their size, polydispersity index (PDI), zeta potential, and cytotoxicity.
Fluorescein release from SEDDS was performed in phosphate buffer (pH 6.8 and pH 8),
and the released fluorescein was evaluated for cellular uptake. Moreover, fluorescein from all of
the SEDDS pre-concentrates was released at different time points to check its long-term stability
over six months.

Results:
The average fluorescein load in SEDDS was 0.045%. SEDDS showed an average droplet
size of 24.9 ± 1.6 nm with PDI ≤ 0.3. SEDDS complexes diluted 1:100 increased the zeta potential
from -7.3 mV to +3.7 mV and provided > 85% cell viability. A 92.27 ± 3.18% fluorescein exhibited
a few seconds of immediate release when used as control or PEI complex in SEDDS. On the
contrary, Eudragit-fluorescein complexes in SEDDS showed sustained release of 87.01 ± 5.22%
fluorescein in ≤ 70 min with 22.19 ± 14.56% and 59.27 ± 16.57% released at 10 min in pH 6.8 and
pH 8 release media, respectively. Comparatively, the medium at pH 6.8 maintained a significantly
improved sustained fluorescein release (p ≤ 0.001). Furthermore, Eudragit RS/RL compared to
Eudragit E, significantly exhibited a slower fluorescein release rate from SEDDS (p ≤ 0.01). The
cellular uptake of the released fluorescein was 72.4 ± 8.2% for all SEDDS complexes after 3 h.
Eudragit complexes compared to PEI complex in SEDDS significantly showed m ore sustained
fluorescein cellular uptake at 1 h and 2 h (p ≤ 0.001). However, SEDDS complexes showed the
longest fluorescein stability with PEI after six months, whereas fluorescein stability for SEDDS
containing fluorescein as Eudragit complex and control showed 39.1% and 82.5% fluorescence
decrease, respectively, after three months.

Conclusion:
In the developed SEDDS, the presence of hydrophobic ionic complexes can significantly
promote longer stability and sustained cellular uptake of fluorescein while releasing in a
sustained manner.
Investigation of Intervention Solutions to Enhance Adherence to Oral Anticancer Medicines in Adults: Overview of Reviews
Authors: Dang Thu Ha , Forkan Abdur Rahim Mohammad , Wickramasinghe Nilmini , Jayaraman Prem Prakash , Alexander Marliese , Burbury Kate , Schofield Penelope 
Published: March 2022

Background
Adherence to anticancer medicines is critical for the success of cancer treatments; however, nonadherence remains challenging, and there is limited evidence of interventions to improve adherence to medicines in patients with cancer.

Objective
This overview of reviews aimed to identify and summarize available reviews of interventions to improve adherence to oral anticancer medicines in adult cancer survivors.

Methods
A comprehensive search of 7 electronic databases was conducted by 2 reviewers who independently conducted the study selection, quality assessment using the A Measurement Tool to Assess Systematic Reviews 2, and data extraction. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist was adapted to report the results.

Results
A total of 29 reviews were included in the narrative synthesis. The overall quality of the systematic reviews was low. The 4 main strategies to promote adherence were focused on education, reminders, behavior and monitoring, and multicomponent approaches. Digital technology–based interventions were reported in most reviews (27/29, 93%). A few interventions applied theories (10/29, 34%), design frameworks (2/29, 7%), or engaged stakeholders (1/29, 3%) in the development processes. The effectiveness of interventions was inconsistent between and within reviews. However, interventions using multiple strategies to promote adherence were more likely to be effective than single-strategy interventions (12/29, 41% reviews). Unidirectional communication (7/29, 24% reviews) and technology alone (11/29, 38% reviews) were not sufficient to demonstrate improvement in adherence outcomes. Nurses and pharmacists played a critical role in promoting patient adherence to oral cancer therapies, especially with the support of digital technologies (7/29, 24% reviews).

Conclusions
Multicomponent interventions are potentially effective in promoting patient adherence to oral anticancer medicines. The seamless integration of digital solutions with direct clinical contacts is likely to be effective in promoting adherence. Future research for developing comprehensive digital adherence interventions should be evidence-based, theory-based, and rigorously evaluated.
PERANCANGAN KEAMANAN SISTEM PENDATAAN GUDANG KOPI MENGGUNAKAN ALGORITMA TRIPLE VIGENERE CHIPER
Authors: Nugraha Elfan , Ummi Khairul 
Published: March 2022

<p><em>Setiap perusahaan memiliki banyak hal yang hanya perusahaan tersebut yang tau, bahkan hanya orang-orang khusus yang ada didalamnya yang mengetahui mengenai kebijakan ataupun data penting milik perusahaan tersebut. Ditambah dengan persaingan dunia bisnis yang ketat dan panasnya persaingan di dunia bisnis keamanan data pribadi perusahaan haruslah tetap terjaga aman.dengan adanya sistem yang canggih di era sekarang ini belum tentu dapat melindungi data-data perusahaan tersebut dari serangan hacker ataupun pihak internal perusahaan yang dengan sengaja menyebarluaskan. </em><em>karena pentingnya menjaga keamanan data perusahaan dan riskannya data untuk dicuri dan disalahgunakan membuat pihak perusahaan menjadi gencar untuk meningkatkan keamanan data perusahaan itu sendiri dengan cara apapun</em><em> </em><em>Dengan adanya sistem ini akan lebih meningkatkan keamanan dari data-data perusahaan. Karena data yang di inputkan oleh karyawan akan terenkripsi dan hanya admin yang dapat memeriksa keaslian data tersebut. Perancangan sistem gudang disini menggunakan bahasa pemrograman php dengan database mysql yang berbasis website dengan menggunakan metode algoritma Triple Vigenere Cipher.</em></p>
PERANCANGAN APLIKASI MOBILE E-COMMERCE PERANGKAT ELEKTRONIK DENGAN MENGGUNAKAN REST API BERBASIS ANDROID
Authors: Surya Wahfiuddin , Syahputra Andrian 
Published: March 2022

<p><em>Sistem pemesanan barang elektronik untuk melengkapi dari costumer masih dilakukan secara bertahap dengan menggunakan brosur ke toko. Sistem pemesanan bertahap ini memiliki beberapa kelemahan, antara lain proses pemesanan barang yang lambat dan kurang efisien. Dari permasalahan diatas maka penulis mengusulkan untuk merancang dan membangun suatu sistem untuk melaksanakan pemesanan barang elektronik dengan memanfaatkan teknologi informasi yang disebut aplikasi dengan istilah sekarang bernama </em>e-commerce <em>menggunakan rest api diaplikasikan melalui smartphone andorid yang dirancang dengan sangat sederhana dan biaya yang relatif murah serta menghemat waktu dalam proses pemesanan barang sehingga memudahkan para costumer. Penggunaan teknologi </em>smartphone android<em> saat ini banyak dipakai untuk ketersediaan transaksi elektronik, karena kecepatan, keamanan dan ketepatan data yang dihasilkan. Aplikasi e-commerce menggunakan teknologi <em>berbasis android </em>dirancang dengan sangat sederhana sehingga memudahkan para pengguna agar dapat dijadikan sebagai media alternatif untuk pemesanan barang secara elektronik.</em></p>
SISTEM PENDUKUNG KEPUTUSAN KELAYAKAN KENAIKAN GAJI PEGAWAI MENGGUNAKAN METODE WASPAS
Authors: Negoro Wahyu Saptha , Wahyuni Linda 
Published: March 2022

<em>Gaji pegawai merupakan hasil kinerja yang diperoleh pegawai selama bekerja, adapun dari kenaikan gaji dikarenakan dari kelayakan atau keberhasilan pegawai dalam mencapai progress yang telah ditentukan oleh pihak perusahaan.</em> S<em>uatu upaya untuk meningkatkan kinerja pada PT. Dwi Tama Prima Sakti adalah memberikan kenaikan gaji kepada pegawai yang layak mendapatkannya. Dalam pemberian kenaikan gaji kadang kala tidak sesuai dengan hasil kinerjanya. Pemberian kenaikan gaji sering kali dipukul rata atau kadang kala pemberian kenaikan gaji hanya dengan memperkirakannya saja, tanpa penerapan perhitungan.</em> <em>PT. Dwi Tama Prima Sakti bergerak di bidang rental construction equipment dimana perusahaan ini menerima jasa pengerjaan tanah, memindahkan bahan bangunan, serta rental alat untuk bangunan</em> <em>yang mana</em> <em>dalam penentuan kenaikan gaji pegawainya belum menggunakan aplikasi komputer. Penentuan kriteria dalam pemilihan kelayakan dari kenailkan gaji ada 4 kriteria diantaranya masa kerja, prestasi, beban kerja dan pendidikan. Sehingga dari 20 data pegawai yang bisa diambil keputusan Layak atau tidaknya dalam penentuan kenaikan gaji diranking lebih besar dari nilai 8 terhadap perhitungan metode WASPAS.</em>
Pengaruh Santan Kelapa Terhadap Laju Pertumbuhan Rumput Laut Eucheuma cottonii
Authors: Tamala Efi , Slamet Agus , Jumiati Jumiati 
Published: March 2022

Rumput laut Eucheuma cottonii merupakan alga yang mengandung karaginan yang berguna dalam berbagai industri. Kualitas rumput laut yang baik dapat ditentukan berdasarkan ukuran talus yang besar. Salah satu upaya untuk mendapatkan talus yang besar adalah dengan memanfaatkan bahan alami berupa santan kelapa yang diperkirakan berperan sebagai zat pengatur tumbuh bagi rumput laut. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian santan kelapa dengan lama perendaman yang berbeda terhadap laju pertumbuhan Eucheuma cottonii. Metode penelitian yang digunakan adalah metode eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan satu faktor yaitu lama perendaman 0, 6, 12, 18 jam. Data yang diperoleh dianalisis menggunakan Analis of varian (ANOVA) pada taraf kepercayaan 95%. Perbedaan hasil antar perlakuan dianalisis dengan Duncan Multiple Range Test (DMRT). Hasil penelitian menunjukkan bahwa pemberian santan kelapa dengan lama perendaman yang berbeda memberikan pengaruh signifikan terhadap pertumbuhan Eucheuma cottonii. Berdasarkan rata-rata parameter pengamatan yang meliputi berat basah, panjang dan kadar air, pemberian santan kelapa dengan lama perendaman 12 jam memberikan laju pertumbuhan Eucheuma cottonii yang lebih tinggi dibandingkan durasi waktu perendaman yang lain.
Model Kepribadian Multikultural Generasi Milenial Memanfaatkan Teknologi Informasi di Masa Pandemi Covid-19 Sebagai Upaya Menumbuhkan Enterpreneur
Authors: Suyono Hadi , Amanda Chintia , Fitroh Rahmah 
Published: March 2022

Penelitian bertujuan mengembangkan model kepribadian multikultural melalui empati dan kepercayaan diri. Metode memilih pendekatan kuantitatif. Pengumpulan data dengan skala likert. Subjeknya adalah 239 siswa di Kabupaten Deli Serdang. Teknik analisis data yang dipilih structural equation modelling menggunakan confirmatory factor analysis first order. Hasil analisis data menunjukkan model kepribadian multikultultural prediktor empati dan kepercayaan diri memenuhi goodness of fit statistics seperti chi-square 563,02, df 517, p-value 0,07905, dan RMSEA 0,019. Berdasarkan hasil analisis data dapat dijelaskan empati dan kepercayaan diri memberi kontribusi pada pembentukan kepribadian multikultural perlu ditumbuhkan untuk memberi manfaaat sebagai soft skills generasi milenial menjadi entrepreneur dalam mengelola bisnis berbasis teknologi informasi.
SISTEM PAKAR DIAGNOSA GEJALA PENYAKIT TUBERKOLOSIS DENGAN METODE DEMPSTER-SHAFER (STUDI KASUS : UPTD PUSKESMAS II TEMON)
Authors: Hidayat Ahmad Yusuf 
Published: March 2022

AbstrakTuberkulosis merupakan penyakit menular yang umum dalam beberapa kasus penyakit yang bersifat mematikan. Penyakit ini disebabkan oleh berbagai strain mikobakteria, umumnya mycobacterium tuberculosis. Tuberkulosis biasanya menyerang paru-paru, namun juga bisa berdampak pada bagian tubuh lainnya.Tujuan penulis dalam penelitian ini adalah Membuat desain prototip Sistem Pakar diagnosa gejala penyakit Tuberkolosis dengan metode Dempster-Shafer berbasis website dan Pengimplementasian metode Dempster-Shafer pada pembuatan sistem pakar. Dari hasil uji yang dilakukan kedua nilai kepercayaan yang di hasilkan secara perhitungan manual dan perhitungan pada sistem telah mencapai diatas 80% dari perhitungan probibalitas saat menentukan dentitas jinis penyakit dari perhitungan dengan metode Dempster-shafer. Kata Kunci: Kecerdasan Buatan,Sistem Pakar,Diagnosa,Tuberkolosis,Dempster-Shafer.
Pengaruh Kejelasan Sasaran Anggaran, Pengendalian Akuntansi dan Sistem Pelaporan terhadap Akuntabilitas Kinerja Instansi Pemerintah dengan Kepatuhan Terhadap Regulasi sebagai Variabel Pemoderasi
Authors: Mulya Helin Gustri , Fauzihardani Eka 
Published: March 2022

This research aimed on analyzing of budget goal clarity, accounting controls and systems reporting for performance accountability government agencies with regulatory compliance as moderating variable. In this research, officials who served as a head agency, finance program and evaluation chiefs, treasurers and finance staff at 30 SKPD in Sungai Penuh district were as a respondent . The sampling method uses purposive sampling, while the data processing method uses multiple linear regression analysis. The amount of samples in this study was 90 respondents. The statistic testing result showed that accounting controls and systems reporting have no effect on performance accountability of government agencies, but variable budget goal clarity have positive significant effect on performance accountability of government agencies. The regulatory compliance as moderating variable could moderated the relationship between variable budget goal clarity, controls accounting and systems reporting with performance accountability of government agencies Sungai Penuh. Suggestions for further research to increase the sample and add new variables that may have an effect.