bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Update on Recently Developed Analytical and Bio-analytical Methods for Some Anticancer Drugs
Authors: Kumar Bhupinder , Akhtar Md Jawaid , Paul Joyson , Singh Karanvir , Pannu Sumit , Pal Rohit , Khan Shah Alam 
Published: November 2022

Abstracts:According to the WHO’s data for 2018, the global cancer burden was estimated to have risen to 18.1 million new cases and which alone accounted for 9.6 million deaths. Cancer is a group of diseases known as tumors that often spreads throughout the body, and may cause harm to multiple organs in the body. The global pharmaceutical spending is around 19% of the R&D cost annually to discover new and potent therapeutic agents. The major problems associated with currently available anticancer drugs are drug resistance and their side effects. They are the most widely explored groups of drugs either using instrumental or bioanalytical methods. In this review, we have compiled and reviewed the analytical and bio-analytical methods of some anticancer drugs developed by different authors. The review also briefly discusses the broad categories of cytotoxic drugs and targeted-based anticancer drugs. The analytical and bioanalytical methods of cytotoxic drugs such as alkylating agents, antimetabolites, hormones, and targetedbased drugs reported earlier and in recent research, articles are discussed in detail. These analytical methods are prerequisites for both the pharmaceutical industry and academics for their impurities profiling and qualitative as well as quantitative estimation. The accuracy, precision, LOD, and LOQ studies by UV-HPLC, LC-MS, and fluorometry HPLC are discussed. Some of the advanced methods developed, in the case of ifosfamide using Au/Pd@rGO@p(L-Cys) and the production of vincristine by endophytic fungi, are also included. This will further embolden the efforts of different researchers working in this field and ease the challenges they face through the analytical development of these drugs.
Evaluation of Water Sorption and Solubility of Nano Titania Enriched Glass Ionomer Cement Considering the Storage Solution and Time
Authors: Hussein Fatma 
Published: November 2022

Background:
A biocompatible additive to glass ionomer cement types without affecting their stability in moisture and dry conditions in demand.TiO2NPs are stable and bioactive nanoparticles that improved the mechanical properties of GICs, but their impact on water sorption and solubility remains undetermined.

Purpose:
This study aimed to evaluate the water sorption/solubility of glass ionomer cement incorporating titanium dioxide nanoparticles (TiO2NPs) in different storage solutions over time.

Methods:
A total of 60 glass ionomer discs were fabricated, and they were divided into two groups (n=30); conventional glass ionomer (control), TiO2 NPs modified glass ionomer. Each group was subdivided into three subgroups according to the type of storage solution used (n=10); artificial saliva, mouthwash with alcohol, and mouthwash without alcohol. Water sorption% and solubility% were recorded after immersion of specimens in the storage solutions according to the subdivided groups; at 24hrs, 1 week, and 1 month.

Results:
TiO2NPs were associated with a significant decrease in sorption% in artificial saliva at 1 week, alcohol at 24hrs, and a significant decrease in solubility% in all storage solutions at 24hrs and artificial saliva at 1 week. There was a significant decrease in water uptake associated with both materials in artificial saliva, also with TiO2NPs modified type in alcohol-free mouth washes. There was a gradual significant increase in solubility% for conventional GIC in artificial saliva and TiO2NPs modified type in alcohol (p≤0.05).

Conclusion:
TiO2NPs may play a promising role in improving water sorption and solubility of conventional GIC, considering the type of storage solution and time.
Patterns in the Use of Heart Failure Telemonitoring: Post Hoc Analysis of the e-Vita Heart Failure Trial
Authors: Brons Maaike , ten Klooster Iris , van Gemert-Pijnen Lisette , Jaarsma Tiny , Asselbergs Folkert W , Oerlemans Marish I F J , Koudstaal Stefan , Rutten Frans H 
Published: November 2022

Background
Research on the use of home telemonitoring data and adherence to it can provide new insights into telemonitoring for the daily management of patients with heart failure (HF).

Objective
We described the use of a telemonitoring platform—including remote patient monitoring of blood pressure, pulse, and weight—and the use of the electronic personal health record. Patient characteristics were assessed in both adherent and nonadherent patients to weight transmissions.

Methods
We used the data of the e-Vita HF study, a 3-arm parallel randomized trial performed in stable patients with HF managed in outpatient clinics in the Netherlands. In this study, data were analyzed from the participants in the intervention arm (ie, e-Vita HF platform). Adherence to weight transmissions was defined as transmitting weight ≥3 times per week for at least 42 weeks during a year.

Results
Data from 150 patients (mean age 67, SD 11 years; n=37, 25% female; n=123, 82% self-assessed New York Heart Association class I-II) were analyzed. One-year adherence to weight transmissions was 74% (n=111). Patients adherent to weight transmissions were less often hospitalized for HF in the 6 months before enrollment in the study compared to those who were nonadherent (n=9, 8% vs n=9, 23%; P=.02). The percentage of patients visiting the personal health record dropped steadily over time (n=140, 93% vs n=59, 39% at one year). With univariable analyses, there was no significant correlation between patient characteristics and adherence to weight transmissions.

Conclusions
Adherence to remote patient monitoring was high among stable patients with HF and best for weighing; however, adherence decreased over time. Clinical and demographic variables seem not related to adherence to transmitting weight.

Trial Registration
ClinicalTrials.gov NCT01755988; https://clinicaltrials.gov/ct2/show/NCT01755988
Frailty, Comorbidity, and Associations With In-Hospital Mortality in Older COVID-19 Patients: Exploratory Study of Administrative Data
Authors: Heyl Johannes , Hardy Flavien , Tucker Katie , Hopper Adrian , Marchã Maria J M , Navaratnam Annakan V , Briggs Tim W R , Yates Jeremy , Day Jamie , Wheeler Andrew , Eve-Jones Sue , Gray William K 
Published: November 2022

Background
Older adults have worse outcomes following hospitalization with COVID-19, but within this group there is substantial variation. Although frailty and comorbidity are key determinants of mortality, it is less clear which specific manifestations of frailty and comorbidity are associated with the worst outcomes.

Objective
We aimed to identify the key comorbidities and domains of frailty that were associated with in-hospital mortality in older patients with COVID-19 using models developed for machine learning algorithms.

Methods
This was a retrospective study that used the Hospital Episode Statistics administrative data set from March 1, 2020, to February 28, 2021, for hospitalized patients in England aged 65 years or older. The data set was split into separate training (70%), test (15%), and validation (15%) data sets during model development. Global frailty was assessed using the Hospital Frailty Risk Score (HFRS) and specific domains of frailty were identified using the Global Frailty Scale (GFS). Comorbidity was assessed using the Charlson Comorbidity Index (CCI). Additional features employed in the random forest algorithms included age, sex, deprivation, ethnicity, discharge month and year, geographical region, hospital trust, disease severity, and International Statistical Classification of Disease, 10th Edition codes recorded during the admission. Features were selected, preprocessed, and input into a series of random forest classification algorithms developed to identify factors strongly associated with in-hospital mortality. Two models were developed; the first model included the demographic, hospital-related, and disease-related items described above, as well as individual GFS domains and CCI items. The second model was similar to the first but replaced the GFS domains and CCI items with the HFRS as a global measure of frailty. Model performance was assessed using the area under the receiver operating characteristic (AUROC) curve and measures of model accuracy.

Results
In total, 215,831 patients were included. The model using the individual GFS domains and CCI items had an AUROC curve for in-hospital mortality of 90% and a predictive accuracy of 83%. The model using the HFRS had similar performance (AUROC curve 90%, predictive accuracy 82%). The most important frailty items in the GFS were dementia/delirium, falls/fractures, and pressure ulcers/weight loss. The most important comorbidity items in the CCI were cancer, heart failure, and renal disease.

Conclusions
The physical manifestations of frailty and comorbidity, particularly a history of cognitive impairment and falls, may be useful in identification of patients who need additional support during hospitalization with COVID-19.
Pengaruh laba kotor, laba operasi, laba bersih, dan modal kerja dalam memprediksi arus kas di masa mendatang pada perusahaan infrastruktur yang terdaftar di Bursa Efek Indonesia Periode 2016-2019
Authors: Aritonang Putri Yunita , Arisandy Aruan Deasy , Sari Manurung Renta , Siti Azzahra Tifa , Rosanti Pasaribu Lisa 
Published: November 2022

This study aims to understand the effect of gross profit, operating profit, net profit, and working capital on future cash flows in infrastructure companies listed on the Indonesia Stock Exchange for the 2016-2019 period. This research uses quantitative methods. The data used is secondary data obtained through the website www.IDX.co.id. The analytical method used is the multiple linear regression analysis method. The results obtained partially gross profit and net profit have a positive and significant effect on cash flows in the future. Meanwhile, operating profit and working capital have no significant effect on future cash flows. Simultaneously gross profit, operating profit, net profit, and working capital have a significant effect on future cash flows in infrastructure companies listed on the Indonesia Stock Exchange for the 2016-2019 period.
Pengaruh penyaluran bantuan langsung tunai , beras miskin, dan subsidi LPG 3 Kg terhadap jumlah rumah tangga miskin di Kabupaten Gresik
Authors: Zidan Izani Muhammad , Taufiq M 
Published: November 2022

The purpose of this research is to estimate the impact of direct cash assistance (BLT), rice for the poor (Raskin), and LPG subsidies on the number of poor families from 2008 to 2020 using multiple linear analytic techniques and secondary data. The results of the study conclude that what is proven to reduce the number of poor households is BLT, because the cash form of the poor can be used to improve their standard of living such as business capital, while the other two variables, namely Raskin and LPG subsidies, actually increase the number of poor households in the form of basic commodities to support daily life - days so there is minimal opportunity to improve the standard of living.
MINAT MEMBACA GENERASI MILLENIAL TERHADAP MEDIA CETAK DAN MEDIA ONLINE DI KECAMATAN PUSAKO KABUPATEN SIAK
Authors: Saputri Azi , Elfiandri Elfiandri 
Published: November 2022

Generasi millenial sebagai sumber daya manusia Indonesia sangat dibutuhkan ide dan pendapatnya untuk membangun negeri ini. Kualitas SDM ini sangat terkait dengan minat membaca yang dimiliki millenial. Kebiasaan membaca dapat dibentuk kepribadian individu dengan menumbuhkan minat bacanya melalui sebuah media baik cetak maupun online. Penelitian ini bertujuan untuk mengetahui bagaimana minat baca generasi millenial terhadap media cetak & media online di kecamatan pusako kabupaten siak. Metode penelitian yang digunakan adalah deskriptif kuantitatif persentase. Sedangkan teknik pengumpulan data yang digunakan yaitu kuisioner dan dokumentasi. Populasi yang digunakan dalam penelitian ini berjumlah 1.861 populasi dengan sampel berjumlah 332 responden. Pengambilan sampel dilakukan dengan metode probability sampling dengan teknik random sampling. Yang menjadi responden yaitu millenial dipilih secara acak di kecamatan pusako kabupaten siak. Hasil penelitian yang didapatkan dalam penelitian ini menunjukkan minat membaca millenial terhadap media cetak dengan skor 38,92, sedangkan minat membaca millenial terhadap media online dengak skor 38,72. Jadi minat membaca millenial terhadap media cetak dan media online tergolong sama-sama kurang baik, namun ada berbedaan skor yaitu 2 poin minat membaca media cetak lebih tinggi dari pada minat membaca media online.
PENERAPAN MEDIA STREAMING YOUTUBE OLEH GEMILANG TV SEBAGAI WADAH INFORMASI DI INDRAGIRI HILIR
Authors: Yudihastira Rizky , Mutia Tika 
Published: November 2022

Televisi merupakan salah satu media mainstream yang selalu mengalami perubahan dan inovasi dalam melakukan siaran. ini disebabkan karena banyak fenomena media baru (new media) yang saat ini bermunculan, salah satunya adalah adanya media sosial berbasis video streaming. media sosial yang memiliki fitur tersebut adalah YouTube. Saat ini, televisi bisa memanfaatkan YouTube sebagai sarana dalam melakukan penyiaran dan berbagi informasi. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana penerapan media streaming YouTube oleh Gemilang TV sebagai wadah informasi yang ada di Indragiri Hilir. Penelitian ini menggunakan paradigma interpretif dengan pendekatan studi kasus. Teknik pengumpulan data menggunakan observasi, wawancara mendalam, dan penelusuran online. teknik pengumpulan data dalam penelitian ini mencakup wawancara, observasi dan dokumentasi. Hasil penelitian menunjukan bahwa Penerapan media streaming YouTube dapat membantu proses produksi Gemilang TV menjadi lebih mudah. Selain itu ditemukan manfaat dari digunakannya media streaming YouTube sebagai wadah untuk berbagi informasi, kemudian menambah produktifitas, mempertinggi efektifitas dan mengembangkan kinerja pekerjaan
APRESIASI MASYARAKAT PEKANBARU DALAM MENDENGARKAN RADIO SIARAN
Authors: Riswandi Riswandi 
Published: November 2022

ABSTRAKApresiasi merupakan sebuah proses yang melibatkan mendengar, menghayati, menilai, menjiwai dan membandingkan atau menghargai suatu karya seni. Penelitian ini bertujuan untuk mengetahui bagaimana apresiasi masyarakat Pekanbaru dalam mendengarkan radio siaran. Subjek penelitian ini adalah masyarakat Pekanbaru. Jenis penelitian ini adalah penelitian deskriptif kuantitatif dan instrumen yang digunakan berupa kuensioner. Populasi dalam penelitian ini berjumlah 1.011.467 jiwa, penulis hanya mengambil 400 orang dijadikan sampel yang telah dibagi dengan rumus Slovin. Teknik analisis data menggunakan analisis deskriptif persentase. Keabsahan data diperoleh melalui validitas dan reliabilitas R (tabel) R (hitung).Hasil penelitian secara parsial menunjukkan bahwa: (1) Berdasarkan hasil analisis Apresiasi Masyarakat Pekanbaru dalam mendengarkan Radio Siaran dari indikator penikmatan dimana mendapatkan hasil sebanyak 68%. (2) Berdasarkan hasil analisis Apresiasi Masyarakat Pekanbaru dalam mendengarkan Radio Siaran dari indikator pemahaman dimana mendapatkan hasil sebanyak 77%. (3) Berdasarkan hasil analisis Apresiasi Masyarakat Pekanbaru dalam mendengarkan Radio Siaran dari indikator penghargaan dimana mendapatkan hasil sebanyak 75%.Secara umum, bahwa Apresiasi Masyarakat Pekanbaru dalam mendengarkan Radio Siaran memiliki apresiasi sebanyak 73% yang dikategorikan Cukup Baik dari hasil deskriptif persentase.
PENERAPAN APLIKASI SIMKAH WEB KEMENTRIAN AGAMA DAN HUBUNGAN TERHADAP APRESIASI MASYARAKAT MENGENAI PELAYANAN PERNIKAHAN DI KUA KECAMATAN TUALANG
Authors: Aprilisma Aprilisma , Elfiandri Elfiandri 
Published: November 2022

Simkah web adalah sebuah inovasi terbaru dalam mengoptimalkan kinerja Kantor Urusan Agama. Rumusan masalah penelitian adalah adakah hubungan dari penerapan Aplikasi Simkah Web terhadap apresiasi masyarakat mengenai pelayanan pernikahan di Kua Tualang. Penelitian ini menggunakan metode penelitian kuantitatif menggunakan teknik sampel proportional random sampling. hasil penelitian yang diperoleh yaitu pada hubungan penerapan aplikasi simkah web dengan apresiasi masyarakat indikator pelayanan dalam bentuk pengamatan memiliki hubungan positif dengan nilai sebesar 0,457 dengan tingkat signifikan 0,000 < 0,05, pada indikator pelayanan bentuk perbuatan dengan nilai sebesar 0,523 dengan tingkat signifikan 0,000 < 0,05, pada indikator pelayanan dalam bentuk perkataan dengan nilai sebesar 0,431dengan tingkat signifikan 0,000 < 0,05, pada indikator pelayanan bentuk pendapat/penilaian dengan nilai sebesar 0,511 dengan tingkat signifikan 0,000 < 0,05 dan hubungan penerapan aplikasi simkah web dengan apresiasi masyarakat mengenai pelayanan pernikahan di Kua Kecamatan Tualang memiliki hubungan positif dengan nilai sebesar 0,635 dengan tingkat signifikan 0,000 < 0,05.
ICT Competence for Prospective Tutors and Teachers
Authors: Balginbayeva Karina 
Published: November 2022

This article shows the effectiveness using electronic portfolio as a means of informatization training aimed at forming the ICT competence for future tutors and teachers taking into account its systematic use in the information and educational environment of the university.
The authors developed the structure and content of the electronic portfolio, as well as the ICT competency model for prospective tutors and teachers while studying the core disciplines by the informatics cycle using the e-portfolio. This model includes the following components: motivational-target, structural-content, procedural-technological, evaluation and result-oriented.
The principle of selection content and structure disciplines aimed at forming ICT-competence has been formulated.
Applying Psychological and Educational Health Models to Determine the Effect of Cognitive and Behavioral Interventions on Tuberculosis Treatment Outcomes in Plateau State, Nigeria
Authors: Sariem Comfort Nanbam , Dapar Maxwell Patrick , Lenka Nenman Musa , Kolawole Jacob , Aguiyi John 
Published: November 2022

Background: The prolonged multi-drug treatment regimen for tuberculosis (TB) can lead to non-adherence and unsuccessful treatment outcomes. Educational and psychological health models can be used to design cognitive and behavioral interventions to improve adherence and treatment outcomes.
Objective: To determine the effect of cognitive and behavioral interventions on TB treatment outcomes.
Methods: The quasi-experimental study conducted in six TB treatment centers involved reinforced medication education and adherence counseling (MEAC), designed from a structured validated psychometric scale. Data were collected three different times during the intensive and continuation phases of treatment from 463 TB patients (232 in the control and 231 in the intervention group). Baseline demographic and clinical characteristics were compared between the groups. The generalized estimating equation model was used to analyze the repeated measures by determining if treatment success was associated with the cognitive and behavioral interventions and medication adherence.
Results: The males made up 290(62.6 %) of the population. The mean age was 36.75±13.9. Most of the TB patients were newly diagnosed 413(89.2%) and HIV negative 315(68%), with secondary level of education 216(46.6%). There was no significant difference in baseline characteristics between the groups. The intervention group was four times more likely to have treatment success (p<0.01; CI=1.5-8.4), compared to the control group. Medication-adherent TB patients were 24 times more likely to have treatment success than patients who did not adhere (p<0.001; 10.8-52.1). TB patients’ emotions, attitudes, and perceptions of their medicines were predictors of treatment success (p<0.05; 1.0 – 1.1).
Conclusion: The cognitive and behavioral interventions administered to TB patients improved successful treatment outcomes.
Efektivitas bentuk latihan Skipping dan Squat Jump terhadap kemampuan Jump Shoot
Authors: Hasanuddin Muhammad Irfan , Syahruddin Syahruddin 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh latihan skipping dan squat jump terhadap kemampuan jump shoot. Jenis penelitian ini adalah eksperimen, variable perlakuan yaitu latihan skipping dan latihan squat jump, sedangkan variable terikat adalah kemampuan jump shoot dalam permainan basket. Populasi penelitian ini adalah siswa ektrakurikuler basket SMA Negeri 10 Makassar sejumlah 200 orang. Sampel dalam penelitian ini adalah siswa ektrakurikuler basket SMA Negeri 10 Makassar yang berjumlah 30 orang, jenis kelamin putra dengan teknik pengambilan sampel menggunakan simple random sampling, dengan pembagian kelompok menggunakan Matched Subjek Ordinal Pairing. Teknik analisis data yang digunakan adalah analisis deskriptif, uji persyaratan, dan uji perbedaan (uji-t) dengan bantuan program SPSS 20.00 pada taraf signifikan 95% atau α 0,05. Hasil penelitian menunjukkan bahwa; 1) Ada pengaruh yang signifikan latihan skipping terhadap kemampuan jump shoot pada siswa ekstrakurikuler basket di SMA Negeri 10 Makassar (p<0,05). 2) Ada pengaruh yang signifikan latihan squat jump terhadap kemampuan jump shoot pada siswa ekstrakurikuler basket di SMA Negeri 10 Makassar (p<0,05), dan 3) Latihan squat jump lebih efektif meningkatkan kemampuan jump shoot daripada latihan skipping (p<0,05).
Learning Management for Productive Technical and Motorcycle Business Subjects at Public Vocational High School 1 Warungasem
Authors: Haryadi Syamsu , Murniati Ngurah Ayu Nyoman , Soedjono Soedjono 
Published: November 2022

This research was motivated in the midst of limited face-to-face learning restrictions that took place during the covid 19 pandemic, but the Warungasem State Vocational High School 1 was still able to excel in the Student Skills Competition at the Central Java Province, by winning 2nd place for the bicycle engineering and business competition. Motorcycle. This study aims to determine the Learning Management of Productive Subjects of Motorcycle Engineering and Business at Public Vocational High School 1 Warungasem. This study uses qualitative research methods, located at the Public Vocational High School 1 Warungasem. Research time in July 2022. Data collection techniques with the method of observation, interviews, and documentation. Test the validity of the data using triangulation. Data analysis includes: data collection, data condensation, data presentation and drawing conclusions. Research results 1) Planning includes (a) preparing the vision, mission and objectives of skill competence (b) preparing work programs (c) preparing planning for productive practice tools and budgets (d) planning for industrial work practices (e) preparing plans for skill competency tests. 2) Organizing includes: (a) formation of management, (b) division of work tasks according to their respective potentials, (c) standard SOPs for implementing tasks (d) coordination and communication in all fields. 3) Implementation includes: (a) theoretical learning in the classroom and (b) practical learning in practice rooms and industrial internships. 4) Supervision includes: (a) internal supervision is carried out by the Principal, and the Deputy Head of Curriculum. (b) external supervision is carried out by Supervisors from the Branch Office of Education Region XIII. Keywords: management, productive learning, motorcycle business engineering