bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudoaneurysm of Distal Anterior Cerebral Artery Secondary to External Ventricular Drain: A Case Report and Review of the Literature
Authors: Reisen Breanne E. , Kinachtchouk Nickolas S. , Hudson Michael L. , Adel Joseph G. 
Published: June 2022

BACKGROUND AND IMPORTANCE:
External ventricular drain (EVD) placement is a common neurosurgical procedure. The risk of hemorrhage is well documented, and the associated risk of pseudoaneurysm is quite rare. Our objective is to report our case of EVD-associated pseudoaneurysm, review the published literature, and suggest management.

CLINICAL PRESENTATION:
A 66-year-old woman presented with subarachnoid hemorrhage secondary to a ruptured posterior communicating artery aneurysm, hydrocephalus was managed with bilateral EVD placement, and the ruptured aneurysm treated with coil embolization. The EVDs were removed, and a tract hemorrhage was noted on the right. Routine imaging 3 months later revealed a cortical pseudoaneurysm along the previous right-sided EVD tract. The pseudoaneurysm was successfully treated with clipping, and the patient is neurologically intact.

CONCLUSION:
This is the first case to report pseudoaneurysm diagnosis after tract hemorrhage upon EVD removal. Prompt treatment is imperative. We recommend considering vascular imaging in any case with hemorrhage upon EVD removal.
Chemical Synthesis of an HIV-1 Protease Analog with Some Amides in a Polypeptide Main Chain Replaced by Disulfide Bonds
Authors: Cui Yan , Taguchi Akihiro , Shida Hayate , Konno Sho , Takayama Kentaro , Taniguchi Atsuhiko , Hayashi Yoshio 
Published: June 2022

AbstractIn this paper, we describe the chemical synthesis of a large artificial protein human immunodeficiency virus type 1 protease (HIV-1 PR) analog with a 115-mer polypeptide chain on which some amide bonds in the main chain have been replaced by disulfide bonds. In this synthesis, a new 3-nitro-2-pyridine (Npy)-sulfenylation agent Npys-OPh(pF), which can form an active disulfide by reaction with a t-Bu protected cysteine residue, was found to be applicable to the efficient and sequential disulfide ligation producing disulfide polypeptides. Two sequential disulfide ligations in three peptide fragments were accomplished for the construction of an HIV-1 PR disulfide analog. In the Trp-containing fragment 2, mesitylenesulfonyl (Mts) protection avoided a side reaction of Npys-OPh(pF), probably at an indole residue. The HIV-1 PR disulfide analog was successfully synthesized from fragment 1 with an isolated yield of 11% by two disulfide ligations of the fragments and the final Mts deprotection of the Trp residue.
Performance Evaluation of a Commercially Available Desiccant-Based Seed Drying System
Authors: Dien Alice , Momin Md Abdul , Ying Tianyu , Spang Edward S. , Kornbluth Kurt , Donis-González Irwin R. 
Published: June 2022

HighlightsDesiccant-based convective drying systems can remove moisture from agricultural commodities.More than 85% of FlexiDry system’s energy consumption was used for desiccant regeneration.Desiccant regeneration provides an opportunity to switch from natural gas or propane combustion to electricity.Greenhouse gas emissions can be reduced in desiccant drying systems by the increased use of renewable electricity.Abstract. FlexiDry® is a commercially available desiccant-based drying system designed to reduce seed moisture content and promote seed preservation. The purpose of this study was to evaluate FlexiDry in drying 130 kg of whole yellow corn kernels (Zea mays) for large-scale human and animal consumption. FlexiDry was tested in two treatments, using heated (HA) and unheated (UA) air, and compared to conventional heated-air (CHA) drying. The desiccant (Drying Beads) was regenerated (moisture removed) at 250°C using a furnace within the FlexiDry system. All treatments properly dried the corn below the target value of 15% dry basis moisture content (MD). The CHA and HA treatments yielded an average moisture extraction rate (MER) of 1.42 kg h-1, compared to 0.58 kg h-1 for the UA treatment. In terms of energy consumption, the specific moisture extraction rate (SMER) was 0.20, 0.44, and 1.11 kg kWh-1 for the UA, HA, and CHA treatments, respectively. The coefficient of performance (COP), i.e., the ratio between the theoretical heat delivered and the total energy consumed, was 0.14, 0.30, and 0.75 for the UA, HA, and CHA treatments, respectively. The FlexiDry treatments (HA and UA) consumed more energy than the CHA treatment, with more than 85% of the energy consumption used to regenerate the Drying Beads. The system yielded a global warming potential (GWP) of 0.931 and 0.425 kg CO2-eq kg-1 of water removed for the UA and HA treatments, respectively. These values are higher than the GWP of the U.S. corn industry drying standard, which is reported as 0.383 kg CO2-eq kg-1 water. Thus, if the regeneration process can be optimized, there is potential for reductions in energy intensity and GWP with large-scale, desiccant-based drying of agricultural commodities. Keywords: ,Dehydration, Energy, Food safety, Moisture, Regeneration.
Development of protective equipment for endoscopic treatment and surgery in otorhinolaryngology
Authors: Matsuwaki Yoshinori , Ariyoshi Daiki , Iwamoto Risa , Morishima Tetsuya , Kimura Keita , Kikuchi Daisuke 
Published: June 2022

Objective
The coronavirus disease pandemic has raised concerns regarding the transmission of infections to healthcare workers. We developed a new protective device to reduce the risk of aerosol diffusion and droplet infection among healthcare workers. Here, we report the results of a theoretical evaluation of the efficacy of this device.

Methods
We used suction-capable masks with and without rubber slits, sleeves for the insertion section of endoscopes and treatment tools, and a cover for the control section of the endoscope. To simulate droplet spread from patients, we created a droplet simulation model and an aerosol simulation model. The results with and without the devices attached and with and without the suction were compared.

Results
The droplet simulation model showed a 95% reduction in droplets with masks with rubber slits; furthermore, a reduction of 100% was observed when the insertion sleeve was used. Evaluation of aerosol simulation when suction was applied revealed an aerosol reduction of 98% and >99% with the use of the mask without rubber slits and with the combined use of the mask and insertion sleeve, respectively. The elimination of droplet emission upon instrument removal confirmed that the instrument sleeve prevented the diffusion of droplets. The elimination of droplets upon repeated pressing of the suction button confirmed that the cover prevented the diffusion of droplets.

Conclusion
We developed a device for infection control, in collaboration with a gastrointestinal endoscopist and Olympus Medical Systems Corporation, that was effective in reducing droplet and aerosol diffusion in this initial theoretical assessment.
Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Authors: Villena-Ortiz Yolanda , Castellote-Bellés Laura , Martinez-Sanchez Luisa , Benítez-Carabante María I. , Miarons Marta , Vima-Bofarull Jaume , Barquin-DelPino Raquel , Paciucci Rosanna , Rodríguez-Frías Francisco , Ferrer-Costa Roser , Casis Ernesto , López-Hellín Joan 
Published: June 2022

Abstract

Objectives
Administration of busulfan is extending rapidly as a part of a conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Monitoring blood plasma levels of busulfan is recommended for identifying the optimal dose in patients and for minimizing toxicity. The aim of this research was to validate a simple, rapid, and cost-effective analytical tool for measuring busulfan in human plasma that would be suitable for routine clinical use. This novel tool was based on liquid chromatography coupled to mass spectrometry.

Methods
Human plasma samples were prepared using a one-step protein precipitation protocol. These samples were then resolved by isocratic elution in a C18 column. The mobile phase consisted 2 mM ammonium acetate and 0.1% formic acid dissolved in a 30:70 ratio of methanol/water. Busulfan-d8 was used as the internal standard.

Results
The run time was optimized at 1.6 min. Standard curves were linear from 0.03 to 5 mg/L. The coefficient of variation (%CV) was less than 8%. The accuracy of this method had an acceptable bias that fell within 85–115% range. No interference between busulfan and the interfering compound hemoglobin, lipemia, or bilirubin not even at the highest concentrations of compound was tested. Neither carryover nor matrix effects were observed using this method. The area under the plasma drug concentration-time curves obtained for 15 pediatric patients who received busulfan therapy prior to HSCT were analyzed and correlated properly with the administered doses.

Conclusions
This method was successfully validated and was found to be robust enough for therapeutic drug monitoring in a clinical setting.
Impacto de la vacunación primaria con BNT162b2 y una dosis de refuerzo homóloga en los anticuerpos IgA contra SARS-CoV-2 en profesionales sanitarios seronegativos
Authors: Salvagno Gian Luca , Henry Brandon M. , Pighi Laura , De Nitto Simone , Lippi Giuseppe 
Published: June 2022

Resumen

Objetivos
En el presente estudio investigamos la respuesta de los anticuerpos IgA a la vacunación primaria con BNT162b2 y una dosis de refuerzo homóloga, en profesionales sanitarios inicialmente seronegativos.

Métodos
La población de estudio consistió en 69 receptores sanos de la vacuna BNT162b2 (dos dosis), seguida de una única dosis de refuerzo homóloga a los ocho meses. Se extrajeron muestras de sangre a lo largo del estudio, con la primera extracción habiéndose realizado previamente a la primera dosis de la vacuna, y la última hasta un mes después de la dosis de refuerzo. Se midieron los niveles séricos de anticuerpos IgA contra el SARS-CoV-2 con el kit Euroimmun Anti-SARS-CoV-2 Spike S1 ELISA IgA.

Resultados
un mes después de la segunda dosis de BNT162b2, se produjo un pico en los niveles de anticuerpos IgA contra el SARS-CoV-2, tras lo cual, fueron disminuyendo paulatinamente los niveles de anticuerpos hasta estabilizarse a los seis meses. La dosis de refuerzo de BNT162b2 (tercera dosis) provocó un segundo pico comparable al observado un mes después de la segunda dosis (p=0,100). Hallamos una correlación muy significativa entre los valores séricos de IgA contra el SARS-CoV-2 antes y después de la dosis de refuerzo (r=0,41; p<0,001), mientras que no se observaron diferencias significativas determinadas por la edad (r=0,10; p=0,416) o el sexo (r=0,04; p=0,729). El índice de receptores seropositivos para IgA contra el SARS-CoV-2 se incrementó del 0% antes de la vacunación, al 80% tras la primera dosis y al 97% tras la segunda dosis de la vacuna, para después disminuir progresivamente al 74% a los tres meses y al 54% a los seis meses, tras lo cual los niveles se estabilizaron. La dosis de refuerzo de BNT162b2 devolvió el índice de seropositividad al 99%.

Conclusiones
Estos resultados fundamentan la propuesta de administrar las dosis de refuerzo de la vacuna tres meses después de la vacunación primaria, con el fin de elevar los niveles de IgA a niveles de protección, especialmente en aquellos grupos de población con mayor riesgo de infección por SARS-CoV-2 o de desarrollar complicaciones.
Various notions of module amenability on weighted semigroup algebras
Authors: Bodaghi Abasalt , Tanha Somaye Grailoo 
Published: June 2022

Abstract
Let

S

S

be an inverse semigroup with the set of idempotents

E

E

. In this article, we find necessary and sufficient conditions for the weighted semigroup algebra

l

1

(

S
,
ω

)

{l}^{1}\left(S,\omega )

to be module approximately amenable (contractible) and module character amenable (as

l

1

(

E

)

{l}^{1}\left(E)

-module).
English as a lingua franca and European identity – parallelisms in their development
Authors: Mocanu Vasilica 
Published: June 2022

AbstractThis paper examines the relationship between English as a lingua franca (henceforth ELF) and European identity. In the first place, the ELF phenomenon and its status in the European context, where multilingual policies prevail, are discussed. Secondly, this article addresses how globalization has triggered identification processes that are novel and should be treated as such and it analyses the characteristics of an alleged European identity, triggered by the pulse of globalizing processes. The role ELF may play in identification processes with Europe is examined. Finally, this article demonstrates that the flexible and hybrid nature of both ELF and European identity make them two very similar phenomena that add an extra layer to localized languages and national identities, respectively. Under this light, the hypothesis is presented that ELF and European identity are interconnected, and that ELF may be an essential condition for a sense of European identity to form.
Residual strength and strengthening capacity of reinforced concrete columns subjected to fire exposure by numerical analysis
Authors: Mohammed Hadeer Riyadh , Said AbdulMuttalib I. 
Published: June 2022

AbstractThis study is a numerical investigation of the performance of reinforced concrete (RC) columns after fire exposure. This study aims to investigate the effect of introducing lateral ties and using the RC jacket on improving post-fire behavior of these columns, the effect of the duration of the fire on ultimate load of columns. The analysis was performed through ABAQUS, a 3D – non-linear finite element program. 4 m tall lengthening square RC column with a cross- section of 0.4 m × 0.4 m was used as a test specimen. The RC column was reinforced by 4Ø28 mm longitudinal bars bonded by steel tie bars of Ø10 mm spaced at 400 mm. The firing temperature was increased to 600°C for 60 min. The results indicated that as the fire load duration increases, the load’s capacity diminishes. The effect of increasing the steel ratio of the RC column resulted in a decrease in the percentage of load reduction following combustion. It was concluded that strengthening columns by RC jackets is efficient and that the axial load capacity of reinforced columns was enhanced.
Synthesis and crystal structure of one new cadmium coordination polymer constructed by phenanthroline derivate and 1,4-naphthalenedicarboxylic acid
Authors: Xu Na , Cui Minghe , Zhang Yueyue , Chang Limin , Kong Zhiguo , Xu Zhanlin 
Published: June 2022

Abstract
A cadmium coordination polymer, [Cd(1,4-NDC)(L)]
n
(1), has been hydrothermally synthesized by using 1-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)naphthalen-2-ol (L) and 1,4-naphthalenedicarboxylic acid (1,4-H2NDC). The complex 1 was characterized by diffraction and elemental analyses. In complex 1, the cadmium ion is distorted octahedral coordinated linking the deprotonated 1,4-NDC anion to form a two-dimensional (2D) layer, and the 2D layer are associated into 3D supramolecular structure via the strong π–π stacking interactions from the conjugated L ligands. In addition, thermogravimetry, powder X-ray diffraction, and the solid-state photoluminescent properties of complex 1 were also studied.
Electrical control of Förster resonant energy transfer across single-layer graphene
Authors: Liu Yansheng , Niño Ortí Miguel Angel , Luo Feng , Wannemacher Reinhold 
Published: June 2022

Abstract
In artificial structures of molecular or quantum dot emitters in contact with single-layer graphene (SLG) Förster-type resonant energy transfer (FRET) can occur unconditionally due to the gapless band structure of SLG. A significant breakthrough for applications, however, would be the electrical modulation of FRET between arbitrary FRET pairs, using the SLG to control this process and taking advantage of the particular band structure and the monatomic thickness of SLG, far below the typical Förster radius of a few nanometers. For a proof of concept, we have therefore designed a Sandwich device where the SLG was transferred onto holey Si3N4 membranes and organic molecules were deposited on either side of the SLG. The relative photoluminescence (PL) intensities of donor and acceptor molecules changed continuously and reversibly with the external bias voltage, and a variation of about 6% of FRET efficiency has been achieved. We ascribe the origin of the electrical modulation of FRET to important doping-dependent nonlocal optical effects in the near field of SLG in the visible range.
Regularity-based spectral clustering and mapping the Fiedler-carpet
Authors: Bolla Marianna , Winstein Vilas , You Tao , Seidl Frank , Abdelkhalek Fatma 
Published: June 2022

Abstract
We discuss spectral clustering from a variety of perspectives that include extending techniques to rectangular arrays, considering the problem of discrepancy minimization, and applying the methods to directed graphs. Near-optimal clusters can be obtained by singular value decomposition together with the weighted

k

k

-means algorithm. In the case of rectangular arrays, this means enhancing the method of correspondence analysis with clustering, while in the case of edge-weighted graphs, a normalized Laplacian-based clustering. In the latter case, it is proved that a spectral gap between the

(

k
−
1

)

\left(k-1)

st and

k

k

th smallest positive eigenvalues of the normalized Laplacian matrix gives rise to a sudden decrease of the inner cluster variances when the number of clusters of the vertex representatives is

2

k
−
1

{2}^{k-1}

, but only the first

k
−
1

k-1

eigenvectors are used in the representation. The ensemble of these eigenvectors constitute the so-called Fiedler-carpet.
La réforme municipale au Nouveau-Brunswick : ses impacts sur le développement territorial
Authors: Simard Majella 
Published: June 2022

La réforme municipale, déposée en novembre 2021 par le gouvernement du Nouveau-Brunswick, étaitattendue depuis longtemps. Le dernier exercice de restructuration territoriale tenu au sein de cette province canadienne remonte au milieu des années 1960. Plus qu’une simple réorganisation municipale, la réforme proposée suggère des changements majeurs en matière de gouvernance, de développement économique et communautaire, mais aussi d’aménagement du territoire. Ces changements seront essentiellement sous la houlette des commissions de services régionaux (CSR). Quels seront les impacts de cette réforme en matière de développement territorial? Telle est la question à laquelle cet article tente de répondre. Compte tenu des fortes disparités locales et régionales qui se manifestent toujours avec beaucoup d’acuité au Nouveau-Brunswick, il demeure impératif que cette réforme, pour qu’elle puisse entraîner des effets bénéfiques sur le développement, soit couplée à une stratégie misant à la fois sur la correction des problèmes structurels et sur le renforcement des capacités des acteurs sociaux.
The municipal reform tabled in November 2021 by the Government of New Brunswick was long overdue. The last territorial restructuring exercise held in this Canadian province took place back to the mid-1960s. More than a simple municipal reorganization, the reform proposes major changes in governance, economic and community development as well as land-use planning. These changes will be essentially held under the leadership of the regional service commissions (RSC). What will be the impacts of this reform in terms of territorial development? This is the question this article attempts to answer. Given the strong local and regional disparities that are still very evident in New Brunswick, it remains imperative that this reform, so that it can have beneficial effects on development, be coupled with a strategy focusing on the correction of structural problems and on the capacity building of social actors.
L’élaboration d’outils pour l’intervention auprès des travailleuses et travailleurs migrants temporaires au Québec
Authors: Frozzini Jorge , Mvogo Balla Valérie 
Published: June 2022

La présence grandissante des travailleuses et des travailleurs migrants temporaires (TMT) sur le territoirecanadien et québécois à travers le Programme des travailleurs étrangers temporaires (PTET) fait en sorte queles demandes pour combler leurs besoins (socioéconomiques, socioculturels, etc.) augmentent année après année. Dans ce contexte, les organismes communautaires sont de plus en plus sollicités pour venir en aide aux TMT afin de faciliter leur accès aux services (médicaux, psychologiques, juridiques) ou simplement afin de clarifier des informations. Malheureusement, ces organismes communautaires ont souvent très peu de ressources pour répondre à toutes les demandes. Ce texte présente une initiative d’élaboration de trois outils (une carte, un répertoire et un guide) pour faciliter le travail d’intervention des acteurs du terrain auprès des TMT. La première section présente les outils et les besoins auxquels ils répondent. La deuxième section se concentre sur les défis rencontrés lors de la conception de ces outils ainsi que de la réception que le projet et les outils ont eue à ce jour. Le texte termine par une réflexion générale.
The growing presence of temporary migrant workers (TMW) in Canada and Quebec through the Temporary Foreign Worker Program (TFWP) means that the demands to meet their needs (socio-economic, socio-cultural, etc.) increase year after year. In this context, community organizations are increasingly solicited to help TMTs, in order to facilitate their access to services (medical, psychological and legal) or simply to clarify information. Unfortunately, these community organizations often have very few resources to respond to all the requests. This text presents an initiative to develop three tools (a map, a directory and a guide) to facilitate the work on the field. The first section presents the tools and the needs they address. The second section focuses on the challenges encountered during the design of these tools and the reception that the project and the tools have had to date. The text concludes with a general reflection.
Using optimal subset regression to identify factors associated with insulin resistance and construct predictive models in the US adult population
Authors: Gong Rongpeng , Liu Yuanyuan , Luo Gang , Yin Jiahui , Xiao Zuomiao , Hu Tianyang 
Published: June 2022

Background
In recent decades, with the development of the global economy and the improvement of living standards, insulin resistance (IR) has become a common phenomenon. Current studies have shown that IR varies between races. Therefore, it is necessary to develop individual prediction models for each country. The purpose of this study was to develop a predictive model of IR applicable to the US population.

Method
In total, 11 cycles of data from the NHANES database were selected for this study. Of these, participants from 1999 to 2010 (n  =  14931) were used to establish the model, and participants from 2011 to 2020 (n  =  13,646) were used to validate the model. Univariate and multivariable logistic regression was used to analyze the factors associated with IR. Optimal subset regression was used to filter the best modeling variables. ROC curves, calibration curves, and decision curve analysis were used to determine the strengths and weaknesses of the model.

Results
After screening the variables by optimal subset regression, variables with covariance were excluded, and a total of seven factors (including HDL, LDL, ALB, GLB, GLU, BMI, and waist) were finally included to establish the prediction model. The AUCs were 0.851 and 0.857 in the training and validation sets, respectively, and the Brier value of the calibration curve was 0.153.

Conclusion
The optimal subset predictive model proposed in this study has a great performance in predicting IR, and the decision curve analysis shows that it has a high net clinical benefit, which can help clinicians and epidemiologists easily detect IR and take appropriate interventions as early as possible.