bluuebunny/crossref_metadata_2025_split huggingface dataset:
State estimation for aoristic models
Authors: van Lieshout Maria N. M. , Markwitz Robin L. 
Published: October 2022

AbstractAoristic data can be described by a marked point process in time in which the points cannot be observed directly but are known to lie in observable intervals, the marks. We consider Bayesian state estimation for the latent points when the marks are modeled in terms of an alternating renewal process in equilibrium and the prior is a Markov point process. We derive the posterior distribution, estimate its parameters and present some examples that illustrate the influence of the prior distribution. The model is then used to estimate times of occurrence of interval censored crimes.
Impaired cell growth under ammonium stress explained by modeling the energy cost of vacuole expansion in tomato leaves
Authors: Poucet Théo , Beauvoit Bertrand , González‐Moro María Begoña , Cabasson Cécile , Pétriacq Pierre , Flandin Amélie , Gibon Yves , Marino Daniel , Dieuaide‐Noubhani Martine 
Published: October 2022

SUMMARYAmmonium (NH4+)‐based fertilization efficiently mitigates the adverse effects of nitrogen fertilization on the environment. However, high concentrations of soil NH4+ provoke growth inhibition, partly caused by the reduction of cell enlargement and associated with modifications of cell composition, such as an increase of sugars and a decrease in organic acids. Cell expansion depends largely on the osmotic‐driven enlargement of the vacuole. However, the involvement of subcellular compartmentation in the adaptation of plants to ammonium nutrition has received little attention, until now. To investigate this, tomato (Solanum lycopersicum) plants were cultivated under nitrate and ammonium nutrition and the fourth leaf was harvested at seven developmental stages. The vacuolar expansion was monitored and metabolites and inorganic ion contents, together with intracellular pH, were determined. A data‐constrained model was constructed to estimate subcellular concentrations of major metabolites and ions. It was first validated at the three latter developmental stages by comparison with subcellular concentrations obtained experimentally using non‐aqueous fractionation. Then, the model was used to estimate the subcellular concentrations at the seven developmental stages and the net vacuolar uptake of solutes along the developmental series. Our results showed ammonium nutrition provokes an acidification of the vacuole and a reduction in the flux of solutes into the vacuoles. Overall, analysis of the subcellular compartmentation reveals a mechanism behind leaf growth inhibition under ammonium stress linked to the higher energy cost of vacuole expansion, as a result of alterations in pH, the inhibition of glycolysis routes and the depletion of organic acids.
An Experimental Study of Feasibility of a Mini-Invasive Fixator for Rib Osteosynthesis
Authors: Puglisi Lucrezia , Ceccarelli Marco , Ambrogi Vicenzo 
Published: October 2022

AbstractAlternatives to the current invasive rib implants are discussed as from the current solutions with their constraints and disadvantages mainly in surgery application and clinical consequences. A novel rib fixator is presented with an experimental validation and characterization for a potential implementation in facilitating osteosynthesis of multifractured ribs. Testing is designed with lab facilities replicating normal breathing with the possibility of simulating cough too. Results of lab test with a ribolution rib fixator prototype are discussed from experiences with pig ribs with satisfactory results in behavior and numerical values.
Effect of Direct Liquid Cooling Technology With Flow Guide Integration on Avionics Devices Thermal and Electrical Performance
Authors: Qi Wenliang , Liu Tingting , Zhang Zichun , Wang Bin , Liu Qi , Xu Yingjie 
Published: October 2022

Abstract
With the application of various high-power electronic devices to improving aircraft comprehensive performance, there has been a significant interest in the use of high heat flux dissipation technology to maintain an effective and safe operation for electronic devices. This article presents a numerical study on the thermal and electrical performance of the avionics server module by using single-phase immersion cooling technology with flow distributor and investigates the influence of heat dissipation capacity on the thermal performance of the avionics server module and DC IR-drop of printed circuit board power distribution network (PDN). The simulation results showed that a higher dielectric fluid flowrate can be provided b flow distributor with the same pumping power, and the maximum temperature of the hot spot was 4–8 °C lower than the module without a flow distributor. The result confirmed the improved flow performance and enhances heat transfer of the hot spot for the module with a flow distributor. However, the module without the flow distributor showed better comprehensive cooling performance with about 10–15% reduction in average Nusselt number with an increase in Re. The discrepancy of PDN DC IR-drop under different Re values was constant at 3% for different design geometries, which means the effect of the flow distributor on power delivery capability can be neglected.
Investigation of Surge in a Transonic Centrifugal Compressor With Vaned Diffuser—Part I: Surge Signature
Authors: Lou Fangyuan , Harrison Herbert M. , Key Nicole L. 
Published: October 2022

Abstract
The identification of stall inception mechanisms and stability-limiting components in a centrifugal compressor is required for the development of effective surge suppression approaches. Part I of this two-part paper investigates the surge signature of a centrifugal compressor at subsonic, transonic, and supersonic inlet tip conditions, and Part II considers the relationship of the surge signature with the compressor static pressure characteristics, as well as the impeller leading edge relative tip Mach number. Experiments were performed in the single stage centrifugal compressor (SSCC) facility at Purdue University with both steady performance and dynamic pressure data recorded. Results show the presence of both mild and deep surges on the compressor map. Deep surge occurs at subsonic and supersonic impeller tip relative Mach numbers while the mild surge is observed as the tip relative Mach number nears unity. Long length-scale modal oscillations can be detected only at the transonic operating condition while spike disturbances are identified as the precursor to instability at subsonic and supersonic tips relative Mach numbers. Finally, the impeller is determined to be the origin of instability throughout most of the compressor map. The observation of impeller-induced instability refreshes the conventional understanding that the diffuser is typically the stability-limiting component for centrifugal compressors with vaned diffusers and suggests various surge suppression approaches may be necessary to achieve range extension throughout a compressor map.
New Concept for Design in Turbomachinery Applications Using Full RANS Gradient Methodology
Authors: Del Rio Armando , Casartelli Ernesto , Fleischli Benno , Mangani Luca 
Published: October 2022

Abstract
Centrifugal compressors are mainly designed with the best efficiency point in mind and the focus oriented toward the impeller. The vaned diffuser geometry is usually developed using simple shapes, such as prismatic blades or wedges, which are unable to account for the flow distortion at the impeller outlet. Investigations of diffuser modifications using computational fluid dynamics (CFD) during the design phase can help to extend the operating range. In order to assess the effect of such modifications, simulations in off-design conditions need to be performed. Accurate predictions of local flow structures at such conditions require a robust flow solver with mixing-plane interfaces and advanced turbulence modeling capabilities. In recent years diffuser modifications were performed mainly based on manual trial-and-error approaches and show considerable potential for improvements. To accelerate the process and allow automation, which is crucial in industrial applications, it is suggested to use an adjoint-based optimization algorithm for diffuser shape design. In this work, a discrete adjoint solver implemented into a robust pressure-based CFD framework was used. While many optimization studies follow the frozen-turbulence approach, which essentially ignores the dependency of the sensitivity on the turbulence quantities, the present adjoint solver fully includes such effects. Automatic differentiation even allows for flexibility with respect to the choice of turbulence model. Any model available in the primal solver can also be used in the adjoint solver. In this particular case, the k–ɛ enhanced wall treatment model was used, since it shows good convergence behavior and is capable of predicting the machine characteristic even at off-design conditions. Mesh morphing was realized via the free-form deformation method, which provides stable mesh deformation and offers a simple and fast setup procedure. Several optimizations were conducted for the RWTH Aachen “Radiver” centrifugal compressor case with vaned diffuser. It was shown that an optimization strategy using a multi-operating point approach, considering part- and overload conditions, is capable of improving the peak efficiency as well as the overall shape of the machine characteristic.
Techno-Economic Comparison of Several Technologies for Waste Heat Recovery of Gas Turbine Exhausts
Authors: Ghilardi Alessandra , Frate Guido Francesco , Baccioli Andrea , Ulivieri Dario , Ferrari Lorenzo , Desideri Umberto , Cosi Lorenzo , Amidei Simone , Michelassi Vittorio 
Published: October 2022

Abstract
The waste heat recovery from the gas turbine (GT) exhaust is typical for increasing performance and reducing CO2 emissions in industrial facilities. Nowadays, numerous already operating gas turbine plants could be retrofitted and upgraded with a bottoming cycle powered by the exhaust gasses. In this case, the standard solution would be to use a water steam Rankine cycle. However, even if this technology usually yields the best efficiency, other alternatives are often preferred on the lower size scale. Organic Rankine cycles (ORCs) are the commercial alternatives to steam Rankine cycles, but many other alternative cycles exist or can be developed, with potential benefits from safety, technical or economic points of view. This study compares several alternative technologies suited to recover gas turbine waste heat, and a detailed cost analysis for each is presented. On this basis, a guideline is proposed for the technology choice considering a wide range of application sizes and temperature levels typical for waste heat recovery from gas turbines. The compared technologies are ORCs, Rankine cycles (RCs) with water and ammonia mixtures at constant composition, supercritical CO2 cycles (sCO2), sCO2 cycles with mixtures of CO2 and other gasses. As it resulted, ORCs can achieve the lowest levelized cost of energy (32 $/MWh–46 $/MWh) if flammable fluids can be employed. Otherwise, Rankine cycles with a constant composition mixture of water and ammonia are a promising alternative, reaching a levelized cost of energy (LCOE) of 36–58 $/MWh.
Increased blood pressure variability during general anaesthesia is associated with worse outcomes after mechanical thrombectomy: a prospective observational cohort study
Authors: Xu Chao , Jin Tianyu , Chen Zhicai , Zhang Zheyu , Zhang Kemeng , Mao Hui , Ye Sasa , Geng Yu , Shi Zongjie 
Published: October 2022

ObjectivesOptimal periprocedural blood pressure (BP) management during mechanical thrombectomy (MT) for acute ischaemic stroke is still controversial. The aim of this study was to investigate the association between intraprocedural BP variability (BPV) and outcomes in patients with large vessel occlusion (LVO) following MT with general anaesthesia.DesignA prospective observational cohort study.SettingThis study was conducted in a single tertiary hospital of Hangzhou in Zhejiang province.ParticipantsA total of 141 patients with LVO treated with MT were finally included between January 2018 and September 2020.Main outcome measuresIntraprocedural BP was recorded every 5 min throughout the procedure. BPV was measured as SD, coefficient of variation (CV), max-min (RANGE) and successive variation. Haemorrhagic transformation was assessed on 24-hour CT images according to European Cooperative Acute Stroke Study III trial. Poor functional outcome was defined as 90-day modified Rankin Scale score 3–6. Binary logistic regression analysis was used to investigate the association of BPV parameters with the incidence of parenchymal haemorrhage (PH) and poor functional outcome.ResultsAfter controlling for age, female, history of smoking, hypertension and atrial fibrillation, baseline National Institutes of Health Stroke Scale, baseline systolic BP (SBP), baseline Alberta Stroke Program Early CT Score, bridging thrombolysis and times of retrieval attempts, the results demonstrated that intraprocedural SBPRANGE (OR 1.029; 95% CI 1.003 to 1.055; p=0.027), SBPSD (OR 1.135; 95% CI 1.023 to 1.259; p=0.017) and SBPCV (OR 1.189; 95% CI 1.053 to 1.342; p=0.005) were independently associated with poor functional outcome. However, the independent association between intraprocedural BPV and PH at 24 hours has not been established in this study.ConclusionsIncreased intraprocedural BPV was more likely to have poor functional outcome in patients with LVO following MT with general anaesthesia. This finding indicates that special precautions should be taken to minimise BP fluctuation during procedure.
Effect of family-centred care on parental mental health and parent–infant interactions for preterm infants: a systematic review protocol
Authors: Cai Qian , Wang Hua , Chen Danqi , Xu Wenli , Yang Rui , Xu Xinfen 
Published: October 2022

IntroductionUnexpected premature delivery and separation from preterm infants are common problems that parents of preterm infants must handle with. Parents of preterm infants may suffer from severe psychological distress. Family-centred care (FCC) can effectively ease parents’ psychological distress and strengthen connections between parents and their preterm infants. The purpose of this systematic review will be to systematically review and evaluate the impacts of FCC interventions on the mental health of parents of preterm infants and the parent–infant relationship.Methods and analysisThis protocol for this systematic review will be conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol. We will search databases including PubMed, Embase, The Cochrane Library, CINAHL, Web of Science, PsycINFO, Scopus and ProQuest, CNKI, SinoMed and Wanfang Data from 1 July 2012 to 1 July 2022. An additional search of OpenGrey will be conducted to identify grey literature. Randomised controlled trials related to FCC inventions for preterm infants≤37 weeks’ gestational age and their parents will be included, and the outcome measures will be parental mental health and parent–infant interaction. Two reviewers will independently conduct title and abstract screening, full-text screening, data extraction and study quality assessment. Risk of bias for the studies will be evaluated using the Cochrane Collaboration Risk of Bias V.2.0. Any disagreements will be solved by a third reviewer to reach a consensus. If appropriate, a meta-analysis will be conducted to assess the effect of FCC on parental mental health and parent–infant relationship.Ethics and disseminationResearch ethics approval will not be required for this review since it will not involve the collection of primary data and will only use published literature. The results will be disseminated in a peer-reviewed journal through publication or by presentation at relevant academic conference.PROSPERO registration numberCRD42022299203.
Impact of a sanitation intervention on quality of life and mental well-being in low-income urban neighbourhoods of Maputo, Mozambique: an observational study
Authors: Ross Ian , Greco Giulia , Adriano Zaida , Nala Rassul , Brown Joe , Opondo Charles , Cumming Oliver 
Published: October 2022

ObjectivesToilet users often report valuing outcomes such as privacy and safety more highly than reduced disease, but effects of urban sanitation interventions on such outcomes have never been assessed quantitatively. In this study, we evaluate the impact of a shared sanitation intervention on quality of life (QoL) and mental well-being.DesignWe surveyed individuals living in intervention and control clusters of a recent non-randomised controlled trial, and used generalised linear mixed regression models to make an observational comparison of outcomes between arms.SettingLow-income unsewered areas of Maputo City, Mozambique.ParticipantsWe interviewed 424 participants, 222 from the prior trial’s intervention group and 202 from the control group.InterventionsThe control group used low-quality pit latrines. The intervention group received high-quality shared toilets, with users contributing 10%–15% of capital cost.OutcomesOur primary outcome was the Sanitation-related QoL (SanQoL) index, which applies respondent-derived weights to combine perceptions of sanitation-related disgust, privacy, safety, health and shame. Secondary outcomes were the WHO-5 mental well-being index and a sanitation Visual Analogue Scale.ResultsThe intervention group experienced a 1.6 SD gain in SanQoL compared with the control group. This adjusted SanQoL gain was 0.34 (95% CI 0.29 to 0.38) on a 0–1 scale with control mean 0.49. Effect sizes were largest for safety and privacy attributes. Intervention respondents also experienced a 0.2 SD gain in mental well-being. The adjusted gain was 6.2 (95% CI 0.3 to 12.2) on a 0–100 scale with control mean 54.4.ConclusionsQoL outcomes are highly valued by toilet users and can be improved by sanitation interventions. Such outcomes should be measured in future sanitation trials, to help identify interventions which most improve people’s lives. Since SanQoL weights are derived from respondent valuation, our primary result can be used in economic evaluation.
Mapping continuous learning using social network research: a social network study of Australian Genomics as a Learning Health System
Authors: Ellis Louise A , Long Janet C , Pomare Chiara , Mahmoud Zeyad , Lake Rebecca , Dammery Genevieve , Braithwaite Jeffrey 
Published: October 2022

ObjectivesTo explore a macrolevel Learning Health System (LHS) and examine if an intentionally designed network can foster a collaborative learning community over time. The secondary aim was to demonstrate the application of social network research to the field of LHS.DesignTwo longitudinal online questionnaires of the Australian Genomics learning community considering relationships between network members at three time points: 2016, 2018, 2019. The questionnaire included closed Likert response questions on collaborative learning patterns and open-response questions to capture general perceptions of the community. Social network data were analysed and visually constructed using Gephi V.0.9.2 software, Likert questions were analysed using SPSS, and open responses were analysed thematically using NVivo.SettingAustralian Genomic Health Alliance.ParticipantsClinicians, scientists, researchers and community representatives.ResultsAustralian Genomics members highlighted the collaborative benefits of the network as a learning community to foster continuous learning in the ever-evolving field of clinical genomics. The learning community grew from 186 members (2016), to 384 (2018), to 439 (2019). Network density increased (2016=0.023, 2018=0.043), then decreased (2019=0.036). Key players remained consistent with potential for new members to achieve focal positions in the network. Informal learning was identified as the most influential learning method for genomic practice.ConclusionsThis study shows that intentionally building a network provides a platform for continuous learning—a fundamental component for establishing an LHS. The Australian Genomics learning community shows evidence of maturity and sustainability in supporting the continuous learning culture of clinical genomics. The network provides a practical means to spread new knowledge and best practice across the entire field. We show that intentionally designed networks provide the opportunity and means for interdisciplinary learning between diverse agents over time and demonstrate the application of social network research to the LHS field.
Testosterone and long pulse width stimulation (TLPS) for denervated muscles after spinal cord injury: a study protocol of randomised clinical trial
Authors: Gorgey Ashraf S , Khalil Refka E , Alrubaye Malak , Gill Ranjodh , Rivers Jeannie , Goetz Lance L , Cifu David X , Castillo Teodoro , Caruso Deborah , Lavis Timothy D , Lesnefsky Edward J , Cardozo Christopher C , Adler Robert A 
Published: October 2022

IntroductionLong pulse width stimulation (LPWS; 120–150 ms) has the potential to stimulate denervated muscles and to restore muscle size in denervated people with spinal cord injury (SCI). We will determine if testosterone treatment (TT)+LPWS would increase skeletal muscle size, leg lean mass and improve overall metabolic health in persons with SCI with denervation. We hypothesise that the 1-year TT+LPWS will upregulate protein synthesis pathways, downregulate protein degradation pathways and increase overall mitochondrial health.Methods and analysisTwenty-four male participants (aged 18–70 years with chronic SCI) with denervation of both knee extensor muscles and tolerance to the LPWS paradigm will be randomised into either TT+neuromuscular electrical stimulation via telehealth or TT+LPWS. The training sessions will be twice weekly for 1 year. Measurements will be conducted 1 week prior training (baseline; week 0), 6 months following training (postintervention 1) and 1 week after the end of 1 year of training (postintervention 2). Measurements will include body composition assessment using anthropometry, dual X-ray absorptiometry and MRI to measure size of different muscle groups. Metabolic profile will include measuring of basal metabolic rate, followed by blood drawn to measure fasting biomarkers similar to hemoglobin A1c, lipid panels, C reactive protein, interleukin-6 and free fatty acids and then intravenous glucose tolerance test to test for insulin sensitivity and glucose effectiveness. Finally, muscle biopsy will be captured to measure protein expression and intracellular signalling; and mitochondrial electron transport chain function. The participants will fill out 3 days dietary record to monitor their energy intake on a weekly basis.Ethics and disseminationThe study was approved by Institutional Review Board of the McGuire Research Institute (ID # 02189). Dissemination plans will include the Veteran Health Administration and its practitioners, the national SCI/D services office, the general healthcare community and the veteran population, as well as the entire SCI community via submitting quarterly letters or peer-review articles.Trial registration numberNCT03345576.