bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRANSFORMASI MEDIA CETAK KE PLATFORM DIGITAL (Analisis Mediamorfosis Harian SOLOPOS)
Authors: Suryawati Indah , Alam Sukma 
Published: November 2022

Terjadinya peningkatan jumlah pengguna media berita online dalam lima tahun terakhir dibanding dengan pengguna media berita konvensional memaksa media cetak untuk melakukan transformasi ke platform digital. Salah satu media yang telah melakukan transformasi media (mediamorfosis) adalah Harian SOLOPOS yang terbit di Solo, Jawa Tengah. Tujuan penelitian ini adalah pertama, untuk mengetahui dan mendeskripsikan mediamorfosis Harian SOLOPOS ke platform digital; dan kedua, untuk menemukan dan menjelaskan model perubahan yang terjadi setelah konsep mediamorfosis diimplementasikan oleh Harian SOLOPOS. Penelitian ini adalah penelitian kualitatif dengan menggunakan paradigma konstruktivis. Adapun metode penelitian yang digunakan adalah metode studi kasus karena objek penelitian ini fokus pada mediamorfosis di Harian SOLOPOS. Hasil penelitian menunjukkan bahwa Harian SOLOPOS benar-benar bermigrasi ke dalam pengelolaan secara digital dengan mendirikan SOLOPOS.com. PT Aksara Solopos, penerbit Harian SOLOPOS, mendirikan Solopos Digital Media yang terdiri atas layanan berupa produk-produk penyebar informasi yang menggunakan teknologi digital. Penataan juga menyentuh perubahan struktur organisasi dan manajerial, pengelolaan Sumber Daya Manusia (SDM), alur dan pola kerja serta dilakukan konvergensi. Di mana konvergensi media SOLOPOS dilakukan dengan mengintegrasikan SOLOPOS (media cetak), SOLOPOS.com (media online), SOLOPOS FM (radio) dan SOLOPOS TV (TV streaming). Model perubahan yang terjadi, SOLOPOS menerapkan tata kelola single newsroom untuk memaksimalkan pengelolaan Harian SOLOPOS, SOLOPOS.com dan SOLOPOS TV. Bahkan reporter SOLOPOS bukan lagi “menjadi’ reporter koran, melainkan berubah menjadi reporter multiplatform baik online, radio maupun TV. Tata kelola seperti ini berdampak pada pemasukan iklan. Meski SOLOPOS.com terlihat lebih unggul dibanding Harian SOLOPOS maupun SOLOPOS TV terkait pemasukan iklan, namun pola pengelolaan iklan dibuat sedemikian rupa dalam bentuk penawaran paket iklan. Kata kunci: Media cetak, Mediamorfosis, Platform digital
#WHATSYOURWAVE DAN #CATCHYOURWAVE DARI MICROGRAM SEBAGAI BENTUK SOSIALISASI ACARA ARCHIPELAGO DI KOTA BANDUNG
Authors: Pratama Yudhi , Hafiar Hanny , Subekti Priyo 
Published: November 2022

Buruknya edukasi, networking serta treatment dalam ekosistem musik mendorong Archipelago dan Microgram untuk mengkampanyekan #WhatsYourWave dan #CatchYourWave Yang mengajak anak-anak muda untuk terus beradaptasi. Melalui penelitiaan ini, peneliti bermaksud untuk mengetahui manajemen kampanye yang dilakukan oleh Microgram Entertainment, mulai dari perencanaan, pelaksanaan hingga evaluasi. Melalui metode penelitian deskriptif serta pengumpulan data dengan wawancara observasi, studi dokumentasi, dan metode penelusuran data daring menghasilkan data sebagai berikut, Langkah pertama adalah perencanaan yaitu kampanye bertema "gelombang" untuk mengubah perilaku target sasaran kampanye; langkah kedua adalah pelaksanaan, yang dimana sebagian besar kampanye bersifat daring, ditambah satu kegiatan luring; langkah ketiga adalah evaluasi, dimana pengukuran keberhasilan kampanye berfokus pada metriks media sosial. Simpulan dari penelitian ini adalah, manajemen kampanye ini tidak sepenuhnya sesuai konsep manajemen kampanye. Pada tahap perencanaan, penetapan tujuan & tolak ukur tidak berkaitan dengan dampak di dunia nyata. Pada tahap pelaksanaan, terdapat kegagalan dalam beberapa tindakan kampanye. Pada tahap evaluasi, hasilnya tidak bisa digunakan untuk mengukur dampak kampanye di dunia nyata. Saran pada penelitian ini pada tahap perencanaan adalah menyusun tujuan yang berkaitan dengan perubahan perilaku. Pada tahap pelaksanaan, mengantisipasi berbagai kemungkinan dengan kru cadangan dan sumber daya gratis/murah. Pada tahap evaluasi, dapat dilakukan dengan mengadakan survei daring sebelum dan sesudah kampanye. Kata kunci: kampanye, manajemen kampanye,
EVALUASI KINERJA PANGKALAN PENDARATAN IKAN HIGIENIS KOTA KENDARI BERDASARKAN ASPEK SANITASI
Authors: Subhany Fajri , Tadjuddah Muslim , Alimina Naslina 
Published: November 2022

Pangkalan Pendaratan Ikan (PPI) Kota Kendari saat ini telah dimanfaatkan dalam kegiatan pembongkaran dan pemasaran ikan baik untuk lokal dan antar pulau, untuk itu mutu dan kualitas hasil tangkapan harus dapat terjamin dengan cara mengoptimalkan fungsi pelabuhan dari aspek sanitasi. Pemanfaatan Pelabuhan ini terus mengalami peningkatan termasuk didalamnya jumlah produksi. Berdasarkan kondisi tersebut maka perlu adanya suatu evaluasi kinerja PPI Kota Kendari yang berbasis tempat pemasaran ikan higienis. Diharapkan dari pelaksanaan penelitian ini dapat memberikan perbaikan pelayanan dalam hal ini peralatan sanitasi dan peningkatan efisiensi agar kinerja PPI Kota Kendari dapat meningkat yang selanjutnya dapat berdampak pada peningkatan mutu hasil tangkapan dan mendorong peningkatan pengembangan sektor perikanan di wilayah ini. Penelitian ini tujuan mengevaluasi kinerja PPI Kota Kendari berdasarkan aspek sanitasi yang sesuai dengan standar teknis TPI Higienis. Penelitian ini diharapkan dapat memberikan manfaat dan sumbangan informasi dalam pengembangan pelabuhan perikanan yang di Kota Kendari berbasis TPI Higienis. Aspek Sanitasi yang dikaji dalam penelitian antara lain : optimalisasi sarana dan prasarana, kebutuhan fasilitas khusus, operator sanitasi, prosedur sanitasi menurut SOP. Dengan responden yang berasal dari UPTD dan Pengelola PPI, kelompok nelayan, pengurus kapal, pengguna PPI yaitu pengunjung atau pembeli. Metode penelitian yang digunakan adalah metode survei. Hasil penelitian menujukkan fasilitas yang terdapat di PPI higienis Kota Kendari belum mendukung pelaksanaan kegiatan TPI higienis berdasarkan aspek sanitasi, dalam operasionalisasi sehari-hari belum melaksanakan sesuai arahan dengan petunjuk teknis TPI higienis
PENGARUH PENAMBAHAN PROPORSI KERANG POKEA (Batissa violacea var. celebensis, von Martens 1897) ASAP YANG BERBEDA TERHADAP NILAI ORGANOLEPTIK DAN PROKSIMAT SAMBAL
Authors: Dari Wulang , Isamu Kobajashi Togo , Nadia Laode Muhamad Hazairin 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan proporsi kerang pokea (Batissa violacea var. celebensis, von Martens 1897) asap terhadap nilai orhanoleptik dan proksimat pada sambal. Parameter yang diuji yaitu uji organoleptik secara deskriptif dan hedonik dan uji proksimat sambal kerang pokea asap. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan menggunakan tiga perlakuan (penambahan proporsi kerang pokea asap sebanyak 40 g, 50 g dan 60 g) masing-masing tiga kali ulangan. Data hasil pengujian dianalisis menggunakan ANOVA (Analysis of Varian), apabila berpengaruh nyata maka dilanjutkan dengan uji DMRT (Duncan Multiple Range Test) pada taraf kepercayaan 95% (α=0,05). Berdasarkan hasil uji organoleptik secara deskriptif dengan parameter warna, aroma, rasa dan tingkat kepedasan berpengaruh nyata terhadap sambal, sedangkan untuk tekstrur tidak berpengaruh terhadap sambal dan organoleptik secara hedonik atau tingkat kesukaan panelis berpengaruh terhadap penambahan proporsi pokea asap kedalam sambal terhadap parameter warna, aroma, rasa dan tekstur yang dimana semakin banyak penambahan proporsi kerang pokea asap maka semakin rendah tingkat kesukaan panelis. Proksimat sambal kerang pokea asap dengan penambahn proporsi kerang pokea asap 40 g, 50 g dan 60 g yaitu kadar air 13,84-18,32%, kadar protein 24,46-29,46%, kadar lemak 36,92-45,82%, kadar abu 3,84-6,15% dan kadar karbohidrat 3,77-8,71%
Analisis Kemampuan Berpikir Kreatif Matematis Ditijau dari Self-Efficacy pada Siswa Kelas VIIb MTS Al Hidaya Tosiba
Authors: Jumriani Jumriani , Salam Mohamad , Awaluddin Awaluddin 
Published: November 2022

Tujuan penelitian ini untuk menganalisis (1) kemampuan berpikir kreatif matematis siswa yang memiliki Self-Efficacy tinggi; (2) kemampuan berpikir kreatif matematis siswa yang memiliki Self-Efficacy sedang; (3) kemampuan berpikir kreatif matematis siswa yang memiliki self-efficacy rendah. Hasil penelitian menunjukkan bahwa: (1) kemampuan berpikir kreatif matematis siswa yang memiliki Self-Efficacy tinggi telah mencapai dua indikator yaitu indikator kelancaran (Fluency), dan indikator keluwesan (Flexibility), belum mencapai untuk indikator keaslian (Originality) maupun indikator keterincian (Elaboration); (2) kemampuan berpikir kreatif matematis siswa yang memiliki Self-Efficacy sedang telah mencapai satu indikator yaitu indikator kelancaran (Fluency), belum mencapai indikator keluwesan (Flexibility), indikator keaslian (Originality) maupun indikator keterincian (Elaboration); (3) kemampuan berpikir kreatif matematis siswa yang memiliki Self-Efficacy rendah yakni tidak ada satupun indikator yang dicapai (indikator kelancaran (Fluency), keluwesan (Flexibility), keaslian (Originality), dan keterincian (Elaboration).
Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5)
Authors: Sibi Joy Manohar , Mohan Viswanathan , Deepa Mohan , Babu Subash , Aravindhan Vivekanandhan 
Published: November 2022

AimMetabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.MethodsWe quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.ResultsMS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both LF- and LF+) subjects. MS-LF+ subjects had significantly increased levels of glucagon, ghrelin, GIP and GLP-1 and decreased levels of adipsin, compared to MS-LF- subjects. Interestingly this effect was short-lived and was not seen in the follow-up samples.ConclusionOverall, LF infection might confer limited short-term beneficial effects against MS, by means of modulating the incretin levels,either directly or indirectly.
Forensic age estimation from human blood using age-related microRNAs and circular RNAs markers
Authors: Wang Junyan , Zhang Haixia , Wang Chunyan , Fu Lihong , Wang Qian , Li Shujin , Cong Bin 
Published: November 2022

Aging is a complicated process characterized by progressive and extensive changes in physiological homeostasis at the organismal, tissue, and cellular levels. In modern society, age estimation is essential in a large variety of legal rights and duties. Accumulating evidence suggests roles for microRNAs (miRNAs) and circular RNAs (circRNAs) in regulating numerous processes during aging. Here, we performed circRNA sequencing in two age groups and analyzed microarray data of 171 healthy subjects (17–104 years old) downloaded from Gene Expression Omnibus (GEO) and ArrayExpress databases with integrated bioinformatics methods. A total of 1,403 circular RNAs were differentially expressed between young and old groups, and 141 circular RNAs were expressed exclusively in elderly samples while 10 circular RNAs were expressed only in young subjects. Based on their expression pattern in these two groups, the circular RNAs were categorized into three classes: age-related expression between young and old, age-limited expression-young only, and age-limited expression-old only. Top five expressed circular RNAs among three classes and a total of 18 differentially expressed microRNAs screened from online databases were selected to validate using RT-qPCR tests. An independent set of 200 blood samples (20–80 years old) was used to develop age prediction models based on 15 age-related noncoding RNAs (11 microRNAs and 4 circular RNAs). Different machine learning algorithms for age prediction were applied, including regression tree, bagging, support vector regression (SVR), random forest regression (RFR), and XGBoost. Among them, random forest regression model performed best in both training set (mean absolute error = 3.68 years, r = 0.96) and testing set (MAE = 6.840 years, r = 0.77). Models using one single type of predictors, circular RNAs-only or microRNAs-only, result in bigger errors. Smaller prediction errors were shown in males than females when constructing models according to different-sex separately. Putative microRNA targets (430 genes) were enriched in the cellular senescence pathway and cell homeostasis and cell differentiation regulation, indirectly indicating that the microRNAs screened in our study were correlated with development and aging. This study demonstrates that the noncoding RNA aging clock has potential in predicting chronological age and will be an available biological marker in routine forensic investigation to predict the age of biological samples.
Improving the prediction for the response to radiotherapy of clinical tumor samples by using combinatorial model of MicroRNA expression
Authors: Tang Chao , Qi Jun , Wu Yan , Luo Ling , Wang Ying , Wu Yongzhong , Shi Xiaolong 
Published: November 2022

Purpose: Radiation therapy (RT) is one of the main treatments for cancer. The response to radiotherapy varies widely between individuals and some patients have poor response to RT treatment due to tumor radioresistance. Stratifying patients according to molecular signatures of individual tumor characteristics can improve clinical treatment. In here, we aimed to use clinical and genomic databases to develop miRNA signatures that can predict response to radiotherapy in various cancer types.Methods: We analyzed the miRNAs profiles using tumor samples treated with RT across eight types of human cancers from TCGA database. These samples were divided into response group (S, n = 224) and progressive disease group (R, n = 134) based on RT response of tumors. To enhance the discrimination for S and R samples, the predictive models based on binary logistic regression were developed to identify the best combinations of multiple miRNAs.Results: The miRNAs differentially expressed between the groups S and R in each caner type were identified. Total 47 miRNAs were identified in eight cancer types (p values &lt;0.05, t-test), including several miRNAs previously reported to be associated with radiotherapy sensitivity. Functional enrichment analysis revealed that epithelial-to-mesenchymal transition (EMT), stem cell, NF-κB signal, immune response, cell death, cell cycle, and DNA damage response and DNA damage repair processes were significantly enriched. The cancer-type-specific miRNA signatures were identified, which consist of 2-13 of miRNAs in each caner type. Receiver operating characteristic (ROC) analyses showed that the most of individual miRNAs were effective in distinguishing responsive and non-responsive patients (the area under the curve (AUC) ranging from 0.606 to 0.889). The patient stratification was further improved by applying the combinatorial model of miRNA expression (AUC ranging from 0.711 to 0.992). Also, five miRNAs that were significantly associated with overall survival were identified as prognostic miRNAs.Conclusion: These mRNA signatures could be used as potential biomarkers selecting patients who will benefit from radiotherapy. Our study identified a series of miRNA that were differentially expressed between RT good responders and poor responders, providing useful clues for further functional assays to demonstrate a possible regulatory role in radioresistance.
Urine metabolomics and microbiome analyses reveal the mechanism of anti-tuberculosis drug-induced liver injury, as assessed for causality using the updated RUCAM: A prospective study
Authors: Wang Ming-Gui , Wu Shou-Quan , Zhang Meng-Meng , He Jian-Qing 
Published: November 2022

BackgroundAnti-tuberculosis drug-induced liver injury (ATB-DILI) is one of the most common adverse reactions that brings great difficulties to the treatment of tuberculosis. Thus, early identification of individuals at risk for ATB-DILI is urgent. We conducted a prospective cohort study to analyze the urinary metabolic and microbial profiles of patients with ATB-DILI before drug administration. And machine learning method was used to perform prediction model for ATB-DILI based on metabolomics, microbiome and clinical data.MethodsA total of 74 new TB patients treated with standard first-line anti-TB treatment regimens were enrolled from West China Hospital of Sichuan University. Only patients with an updated RUCAM score of 6 or more were accepted in this study. Nontargeted metabolomics and microbiome analyses were performed on urine samples prior to anti-tuberculosis drug ingestion to screen the differential metabolites and microbes between the ATB-DILI group and the non-ATB-DILI group. Integrating electronic medical records, metabolomics, and microbiome data, four machine learning methods was used, including random forest algorithm, artificial neural network, support vector machine with the linear kernel and radial basis function kernel.ResultsOf all included patients, 69 patients completed follow-up, with 16 (23.19%) patients developing ATB-DILI after antituberculosis treatment. Finally, 14 ATB-DILI patients and 30 age- and sex-matched non-ATB-DILI patients were subjected to urinary metabolomic and microbiome analysis. A total of 28 major differential metabolites were screened out, involving bile secretion, nicotinate and nicotinamide metabolism, tryptophan metabolism, ABC transporters, etc. Negativicoccus and Actinotignum were upregulated in the ATB-DILI group. Multivariate analysis also showed significant metabolic and microbial differences between the non-ATB-DILI and severe ATB-DILI groups. Finally, the four models showed high accuracy in predicting ATB-DILI, with the area under the curve of more than 0.85 for the training set and 1 for the validation set.ConclusionThis study characterized the metabolic and microbial profile of ATB-DILI risk individuals before drug ingestion for the first time. Metabolomic and microbiome characteristics in patient urine before anti-tuberculosis drug ingestion may predict the risk of liver injury after ingesting anti-tuberculosis drugs. Machine learning algorithms provides a new way to predict the occurrence of ATB-DILI among tuberculosis patients.
Advanced primary vaginal squamous cell carcinoma: A case report and literature review
Authors: Shen Yue , Meng Xiangkai , Wang Lili , Wang Xiaoxiao , Chang Hua 
Published: November 2022

BackgroundVaginal carcinoma is a gynecological malignancy with low incidence, and there are few relevant and specific guidelines for vaginal cancer in our country and abroad. Here, we report the case who was diagnosed with advanced, primary vaginal squamous cell carcinoma and underwent integrated treatment successfully.Case introductionA 64-year-old Chinese woman underwent subtotal hysterectomy for uterine fibroids in 1998 and laparoscopic extensive residual cervical resection, bilateral ovarian salpingectomy, and pelvic lymph node dissection for residual cervical adenocarcinoma (stage IB1) in the First Affiliated Hospital of China Medical University in 2018. There was no postoperative review. The patient experienced vaginal discharge in March 2020, and vaginal bleeding occurred in July 2020. Our patient was diagnosed with stage IVA vaginal squamous cell carcinoma, based on a gynecological examination, colposcopy biopsy with histopathological examination, computed tomography scan, and tumor marker levels by two professors. After three phases of treatment (sequential treatment with chemotherapy plus radiotherapy, chemotherapy combined with immune checkpoint inhibitors, and immune checkpoint inhibitors combined with tyrosine kinase inhibitors therapy), her condition improved. Her current state is generally good, and she has achieved complete remission.ConclusionWe report a rare case of a patient with primary advanced vaginal carcinoma combined with cervical adenocarcinoma. The patient was treated for approximately 2 years, and her personalized treatment showed promising results. We will continue to follow up with the patient and monitor her response to the current treatment process.
Enhanced phycocyanin production of Arthrospira maxima by addition of mineral elements and polypeptides using response surface methodology
Authors: Yao Ting , Huang Jianke , Su Bocheng , Wei Liang , Zhang Ai-Hua , Zhang Dao-Feng , Zhou Yongsheng , Ma Guangyuan 
Published: November 2022

IntroductionAs a pigment protein, phycocyanin has been widely used in the fields of food, nutraceutical and biotechnology due to its excellent biological activities of antioxidant. So far, Arthrospira has been generally considered as a great species for phycocyanin production.MethodsIn this study, independent and interactive effect of three factors, NaCl, Bainengsi (BS) and Bainengtai (BT) on microalgae growth and phycocyanin production were explored by response surface methodology (RSM). Using Box-Behnken design (BBD) method, the well-fitting quadratic models were established based on experimental results.ResultsMoreover, the maximum phycocyanin concentration reached 704.66 mg L-1 at the optimal condition (185 mM NaCl, 200 mg L-1 BS, and 20 mg L-1 BT), while the maximum phycocyanin content of 19.03% was obtained at another optimal condition (136 mM NaCl, 200 mg L-1 BS, and 50 mg L-1 BT). Compared to control, the concentration and content of phycocyanin were increased by 22.98% and 16.73%, respectively.DiscussionOverall, this study demonstrated that addition of exogenous substances (BS, BT) into culture medium optimized by RSM was an effective approach to increase phycocyanin production, which paved a potential way to realizing high efficient production of algal biomass and bioactive substances.
Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
Authors: Liu Mengxi , Li Fang , Wang Xiaoqing , Liu Zhenru , Wong Hoi Shiwn , Zhou Yuan , Wang Daguang 
Published: November 2022

BackgroundOnychopapilloma is generally recognized as a benign tumor of the nail bed and distal matrix. However, the origin of onychopapilloma has not been explained yet.ObjectiveTo clarify the origin of onychopapilloma, we detected the expression patterns of hair-related keratins and epithelial keratins, which are expressed specifically in the nail unit.Materials and methodsThe clinical and histopathologic features of 11 patients with onychopapilloma were analyzed, and the expression patterns of hair-related and epithelial keratins were detected.ResultsHistologically, all subjects showed acanthosis, papillomatosis and matrix metaplasia within the nail bed. Immunohistochemically, the expression pattern of keratins in our standard nail unit was consistent with previous reports. “Nail matrix-related keratins” HK31, HK34, HK85, and HK86 were only expressed in the nail matrix, and “Nail bed-related keratins” HK75 and K6/K16 were only expressed in the nail bed. However, in onychopapilloma, whether adjacent to the matrix or in the distal nail bed, all cases were positive for nail bed-related keratins and HK31 but negative for other nail matrix-related keratins.ConclusionOur study suggests that onychopapilloma may originate from the nail bed rather than the nail matrix. Furthermore, the expression of nail bed-related keratins and HK31 could be used as diagnostic markers of onychopapilloma.