bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Same Tone, but a New Sound—Understanding the Story of the Soul as Pathway to Regenerative Civilizations
Authors: Zettel Christa 
Published: March 2022

AbstractThis chapter takes not only into a historic perspective that looks at human consciousness development over many millennia, but emphasizes the importance of mythology as the most deeply ingrained way of humankind to keep learning for transformations. The author argues, contrary to the modern mind’s needs, that the creative aspect of change or transformation is not order, but disorder or chaos. To avoid the final fragmentation or destruction of our world, the intuitive ‘universal power of self-renewal’ (the life instinct) needs to be reintegrated into rational science, to fill our scientific particularization (the death instinct) with meaning, which is adequate to living in a humane way on our planet. This makes the story of the soul (Greek: psyche), which is passed on by peoples and cultures in a nonlinear-out-of-time-way, not only an important resource to understand the entire civilizational process and subsequently the development of regenerative civilizations. By allowing the forthcoming of an innate integral structure in the human mind, which uses both rationality and intuition, creative mythology is a discipline important for transformation literacy. It can contribute to the so much needed acceleration and speed up the process of collective regeneration, because this is a creative act and unleashes what was previously impossible.
Setting the Scene: Viewing the World as Interconnected Systems
Authors: Ragnarsdottir Kristin Vala 
Published: March 2022

AbstractThis chapter gives a conceptual overview for viewing the world as interconnected systems. Systems have interconnected stock and flows, and change in one part of the system has nonlinear effects on the whole system due to causes and effects that can be mapped. The systems that are outlined are the Earth system, the economic system, the financial system, the education system, and the innovation system. Other systems that are briefly mentioned include the food system, the biological system, the climate system, and community systems. All of these systems (and more) are interconnected in a complex manner, and to achieve a regenerative global system, it is not enough to focus in our education system on environmental and sustainability literacy but on an overarching transformation literacy as outlined in this book. Thus, due to of the interconnectedness of the various systems, holistic education and environmental policy making alone will not achieve the transformations called for.
Everything is Connected—Envisioning How a Regenerative World Looks Like
Authors: Ragnarsdottir Kristin Vala 
Published: March 2022

AbstractThe rationale for why visioning a regenerative world in the future is presented. Based on the visioning strategy of Donella Meadows, the future is envisioned from 2021 on. In addition to answering the questions of Meadows of how a regenerative world would look like, the importance of building a sustainable economy is outlined, an economy that regenerates the natural world and communities. Several models have been outlined, and in this chapter, the focus is on the wellbeing economy, the regenerative economy in service of life, and the doughnut economy. An action plan of how to direct the economy to be within planetary boundaries based on degrowth for the global North is presented. Other systems are briefly outlined as being important including sustainable natural- and food systems. All of these systems are interconnected in a complex manner and therefore need to be studied together.
Holographic complexity of quantum black holes
Authors: Emparan Roberto , Frassino Antonia Micol , Sasieta Martin , Tomašević Marija 
Published: March 2022

Abstract
We analyze different holographic complexity proposals for black holes that include corrections from bulk quantum fields. The specific setup is the quantum BTZ black hole, which encompasses in an exact manner the effects of conformal fields with large central charge in the presence of the black hole, including the backreaction corrections to the BTZ metric. Our results show that Volume Complexity admits a consistent quantum expansion and correctly reproduces known limits. On the other hand, the generalized Action Complexity picks up large contributions from the singularity, which is modified due to quantum backreaction, with the result that Action Complexity does not reproduce the expected classical limit. Furthermore, we show that the doubly-holographic setup allows computing the complexity coming purely from quantum fields — a notion that has proven evasive in usual holographic setups. We find that in holographic induced-gravity scenarios the complexity of quantum fields in a black hole background vanishes to leading order in the gravitational strength of CFT effects.
Spectral functions of heavy quarkonia in a bulk-viscous quark gluon plasma
Authors: Thakur Lata , Hirono Yuji 
Published: March 2022

Abstract
We study the properties of quarkonia inside a bulk-viscous quark gluon plasma. The non-equilibrium nature of the medium is encoded in the deformed distribution functions of thermal quarks and gluons, with which we compute the dielectric permittivity within the hard thermal loop approximation at one-loop. The modified dielectric permittivity is used to calculate the in-medium heavy quark potential, and using the potential we compute spectral functions, which reflect the physical properties of heavy quarkonia. We discuss how the bulk viscous effect influences quantities such as binding energies and thermal widths. Based on those properties, we discuss the implications of the bulk viscous effect on the physical observables such as ψ′ to J/ψ ratio and the nuclear modification factor, RAA. In particular, we argue that the nuclear modification factors of excited and ground states show different sensitivities to the bulk viscous nature of a plasma, which is potentially useful for the critical point search.
Thermalization of holographic excited states
Authors: Martínez Pedro Jorge , Silva Guillermo A 
Published: March 2022

Abstract
We propose a real time holographic framework to study thermalization processes of a family of QFT excited states. The construction builds on Skenderis-van Rees’s holographic duals to QFT Schwinger-Keldysh complex-time ordered paths. Thermalization is explored choosing a set of observables Fn which essentially isolate the excited state contribution. Focusing on theories defined on compact manifolds and with excited states defined in terms of Euclidean path integrals, we identify boundary conditions that allow to avoid any number of modes in the initial field state. In the large conformal dimensions regime, we give precise prescriptions on how to compute the observables in terms of bulk geodesics.
Wormholes and spectral statistics in the Narain ensemble
Authors: Collier Scott , Maloney Alexander 
Published: March 2022

Abstract
We study the spectral statistics of primary operators in the recently formulated ensemble average of Narain’s family of free boson conformal field theories, which provides an explicit (though exotic) example of an averaged holographic duality. In particular we study moments of the partition function by explicit computation of higher-degree Eisenstein series. This describes the analog of wormhole contributions coming from a sum of over geometries in the dual theory of “U(1) gravity” in AdS3. We give an exact formula for the two-point correlation function of the density of primary states. We compute the spectral form factor and show that the wormhole sum reproduces precisely the late time plateau behaviour related to the discreteness of the spectrum. The spectral form factor does not exhibit a linear ramp.
VH + jet production in hadron-hadron collisions up to order $$ {\alpha}_{\mathrm{s}}^3 $$ in perturbative QCD
Authors: Gauld R. , Gehrmann-De Ridder A. , Glover E. W. N. , Huss A. , Majer I. 
Published: March 2022

Abstract
We present precise predictions for the hadronic production of an on-shell Higgs boson in association with a leptonically decaying gauge boson and a jet up to order $$ {\alpha}_{\mathrm{s}}^3 $$

α
s
3

. We include the complete set of NNLO QCD corrections to both charged- and neutral-current Drell-Yan type contributions, as well as the previously known leading heavy quark loop induced contributions which involve a direct Higgs-quark coupling. As an application, we study a range of differential observables in proton-proton collisions at $$ \sqrt{s} $$

s

= 13 TeV for both the charged- and neutral-current production modes. For each Higgs production process, we assess the improvement in the theoretical uncertainty for both the exclusive (njet = 1) and inclusive (njet ≥ 1) jet categories. We find that the inclusion of the NNLO corrections to the Drell-Yan type contributions is essential in stabilising the predictions and in reducing the theoretical uncertainty for both inclusive and exclusive jet production for all three modes. This is particularly true in the kinematical regimes associated with low to medium values of the transverse momentum of the produced vector boson and where the differential cross sections are the largest. For the neutral-current process, we find that the heavy quark loop induced contributions have their largest phenomenological impact (an increase in the size of the NNLO corrections, a distortion of the distribution shape and an enlargement of the left over remaining uncertainties) in kinematical regions associated to large values of pT,Z (typically above 150 GeV) where the cross sections are smaller.
All-multiplicity amplitudes with four massive quarks and identical-helicity gluons
Authors: Lazopoulos Achilleas , Ochirov Alexander , Shi Canxin 
Published: March 2022

Abstract
We explore the on-shell recursion for tree-level scattering amplitudes with massive spinning particles. Based on the factorization structure encoded in the same way by two different recursion relations, we conjecture an all-multiplicity formula for two gauged massive particles of arbitrary spin and any number of identical-helicity gluons. Specializing to quantum chromodynamics (QCD), we solve the on-shell recursion relations in the presence of two pairs of massive quarks and an arbitrary number of identical-helicity gluons. We find closed-form expressions for the two distinct families of color-ordered four-quark amplitudes, in which all gluons comprise a single color-adjacent set. We compare the efficiency of the numerical evaluation of the two resulting analytic formulae against a numerical implementation of the off-shell Berends-Giele recursion. We find the formulae for both amplitude families to be faster for large multiplicities, while the simpler of the two is actually faster for any number of external legs. Our analytic results are provided in a computer-readable format as two files in the supplementary material.
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease
Authors: Marengo Liana , Armbrust Fred , Schoenherr Caroline , Storck Steffen E. , Schmitt Ulrich , Zampar Silvia , Wirths Oliver , Altmeppen Hermann , Glatzel Markus , Kaether Christoph , Weggen Sascha , Becker-Pauly Christoph , Pietrzik Claus U. 
Published: March 2022

Abstractβ-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the major described β-secretase to generate Aβ peptides in Alzheimer’s disease (AD). However, all therapeutic attempts to block BACE1 activity and to improve AD symptoms have so far failed. A potential candidate for alternative Aβ peptides generation is the metalloproteinase meprin β, which cleaves APP predominantly at alanine in p2 and in this study we can detect an increased meprin β expression in AD brain. Here, we report the generation of the transgenic APP/lon mouse model of AD lacking the functional Mep1b gene (APP/lon × Mep1b−/−). We examined levels of canonical and truncated Aβ species using urea-SDS-PAGE, ELISA and immunohistochemistry in brains of APP/lon mouse × Mep1b−/−. Additionally, we investigated the cognitive abilities of these mice during the Morris water maze task. Aβ1-40 and 1–42 levels are reduced in APP/lon mice when meprin β is absent. Immunohistochemical staining of mouse brain sections revealed that N-terminally truncated Aβ2–x peptide deposition is decreased in APP/lon × Mep1b−/− mice. Importantly, loss of meprin β improved cognitive abilities and rescued learning behavior impairments in APP/lon mice. These observations indicate an important role of meprin β within the amyloidogenic pathway and Aβ production in vivo.
Positive Jantzen sum formulas for cyclotomic Hecke algebras
Authors: Mathas Andrew 
Published: March 2022

AbstractThis paper proves a “positive” Jantzen sum formula for the Specht modules of the cyclotomic Hecke algebras of type A and uses it to obtain new bounds on decomposition numbers. Quite remarkably, our results are proved entirely inside the cyclotomic Hecke algebras. Our positive sum formula shows that, in the Grothendieck group, the Jantzen sum formula can be written as an explicit non-negative linear combination of modules $$[E^{\varvec{\nu }}_{f,e}]$$

[

E

f
,
e

ν

]

, which are the modular reductions of simple modules of related Hecke algebras in characteristic zero. The coefficient of $$[E^{\varvec{\nu }}_{f,e}]$$

[

E

f
,
e

ν

]

in the sum formula is determined by the graded decomposition numbers in characteristic zero, which are known, and by the characteristic of the field. As a consequence we give an explicit upper bound for the decomposition numbers in characteristic $$p>0$$

p
>
0

in terms of linear combinations of decomposition numbers of a cyclotomic Hecke algebra at $$ep^r$$

e

p
r

th roots of unity in characteristic zero, for $$r\ge 0$$

r
≥
0

. Finally, we prove a new and more elegant “classical” Jantzen sum formula for these algebras.
Multiple phenotypic traits predict male mating success in a critically endangered frog
Authors: Kelleher Shannon R. , Silla Aimee J. , McFadden Michael S. , Stares Mitchell G. , Endler John A. , Byrne Phillip G. 
Published: March 2022

AbstractComplex sexual signals spanning multiple sensory modalities may be common in nature, yet few studies have explored how combinations of phenotypic traits influence male attractiveness and mating success. Here, we investigate whether combinations of multiple male phenotypic traits (both within and across sensory modalities) predict male mating and fertilization success in the critically endangered southern corroboree frog,Pseudophryne corroboree. We conducted breeding trials in a standardized captive environment where females were given the opportunity to choose between multiple males over the duration of the breeding season. For each male, we measured multiple call traits, aspects of coloration, body size, and age. We found that complex interactions between multiple traits best predicted male mating and fertilization success. In general, males with lower call frequency, lower call rate, and shorter call duration had the highest mating and fertilization success. Fertilization success was additionally linked to male body size and age. These findings suggest that femaleP. corroboreeselect mates based on a suite of acoustic traits, adding to a growing body of evidence that females use multiple traits to assess male quality. Our results also suggest that females may combine information from multiple signals non-additively. Moreover, our results imply that females gain direct fertility benefits from their mate choice decisions. We argue that understanding female mate choice based on various signals across multiple sensory modalities has important implications for the integration of mate choice into conservation breeding programs and needs to be considered when developing behavior-based captive breeding strategies.Significance statementSexual signals are often highly complex, yet we know little about how multiple signal components both within and across various sensory modalities predict male mating success. We investigated whether combinations of multiple phenotypic traits (within and across sensory modalities) predicted male breeding success in threatened corroboree frogs. We conducted captive breeding trials in a homogeneous environment, where females could choose between multiple males over the duration of a single breeding season. We found that interactions between multiple male traits predicted mating and fertilization success. Males with lower call frequency, call rate, and duration had higher mating success. Fertilization success was also linked to acoustic signals, body size, and age. Understanding mate choice for multiple traits further elucidates the complexity of female mate choice. This study is one of the first to consider the conservation implications of multimodal signaling in mate choice.
The role of computed tomography in the assessment of tumour extent and the risk of residual disease after upfront surgery in advanced ovarian cancer (AOC)
Authors: Asp Mihaela , Malander Susanne , Wallengren Nils-Olof , Pudaric Sonja , Bengtsson Johan , Sartor Hanna , Kannisto Päivi 
Published: March 2022

Abstract
Purpose
Epithelial ovarian cancer is usually diagnosed in the advanced stages. To choose the best therapeutic approach, an accurate preoperative assessment of the tumour extent is crucial. This study aimed to determine whether the peritoneal cancer index (PCI), the amount of ascites, and the presence of cardiophrenic nodes (CPLNs) visualized by computed tomography (CT) can assess the tumour extent (S-PCI) and residual disease (RD) for advanced ovarian cancer (AOC) patients treated with upfront surgery.

Methods
In total, 118 AOC cases were included between January 2016 and December 2018 at Skåne University Hospital, Lund, Sweden. Linear regression and interclass correlation (ICC) analyses were used to determine the relationship between CT-PCI and S-PCI. The patients were stratified in complete cytoreductive surgery (CCS) with no RD or to non-CCS with RD of any size. The amount of ascites on CT (CT-ascites), CA-125 and the presence of radiological enlarged CPLNs (CT-CPLN) were analysed to evaluate their impact on estimating RD.

Results
CT-PCI correlated well with S-PCI (0.397; 95% CI 0.252–0.541; p < 0.001). The risk of RD was also related to CT-PCI (OR 1.069 (1.009–1.131), p < 0.023) with a cut-off of 21 for CT-PCI (0.715, p = 0.000). The sensitivity, specificity, positive predictive value and negative predictive value were 58.5, 70.3, 52.2 and 75.4%, respectively. CT-ascites above 1000 ml predicted RD (OR 3.510 (1.298–9.491) p < 0.013).

Conclusion
CT is a reliable tool to assess the extent of the disease in advanced ovarian cancer. Higher CT-PCI scores and large volumes of ascites estimated on CT predicted RD of any size.
Complex hereditary peripheral neuropathies caused by novel variants in mitochondrial-related nuclear genes
Authors: Hiramatsu Yu , Okamoto Yuji , Yoshimura Akiko , Yuan Jun-Hui , Ando Masahiro , Higuchi Yujiro , Hashiguchi Akihiro , Matsuura Eiji , Nozaki Fumihito , Kumada Tomohiro , Murayama Kei , Suzuki Mikiya , Yamamoto Yuki , Matsui Naoko , Miyazaki Yoshimichi , Yamaguchi Masamitsu , Suzuki Youji , Mitsui Jun , Ishiura Hiroyuki , Tanaka Masaki , Morishita Shinichi , Nishino Ichizo , Tsuji Shoji , Takashima Hiroshi 
Published: March 2022

AbstractMitochondrial disorders are a group of clinically and genetically heterogeneous multisystem disorders and peripheral neuropathy is frequently described in the context of mutations in mitochondrial-related nuclear genes. This study aimed to identify the causative mutations in mitochondrial-related nuclear genes in suspected hereditary peripheral neuropathy patients. We enrolled a large Japanese cohort of clinically suspected hereditary peripheral neuropathy patients who were mutation negative in the prescreening of the known Charcot–Marie–Tooth disease-causing genes. We performed whole-exome sequencing on 247 patients with autosomal recessive or sporadic inheritance for further analysis of 167 mitochondrial-related nuclear genes. We detected novel bi-allelic likely pathogenic/pathogenic variants in four patients, from four mitochondrial-related nuclear genes: pyruvate dehydrogenase beta-polypeptide (PDHB), mitochondrial poly(A) polymerase (MTPAP), hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, beta subunit (HADHB), and succinate-CoA ligase ADP-forming beta subunit (SUCLA2). All these patients showed sensory and motor axonal polyneuropathy, combined with central nervous system or multisystem involvements. The pathological analysis of skeletal muscles revealed mild neurogenic changes without significant mitochondrial abnormalities. Targeted screening of mitochondria-related nuclear genes should be considered for patients with complex hereditary axonal polyneuropathy, accompanied by central nervous system dysfunctions, or with unexplainable multisystem disorders.
Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositis
Authors: Johari Mridul , Vihola Anna , Palmio Johanna , Jokela Manu , Jonson Per Harald , Sarparanta Jaakko , Huovinen Sanna , Savarese Marco , Hackman Peter , Udd Bjarne 
Published: March 2022

Abstract
Objective
Inclusion body myositis (IBM) has an unclear molecular etiology exhibiting both characteristic inflammatory T-cell activity and rimmed-vacuolar degeneration of muscle fibers. Using in-depth gene expression and splicing studies, we aimed at understanding the different components of the molecular pathomechanisms in IBM.

Methods
We performed RNA-seq on RNA extracted from skeletal muscle biopsies of clinically and histopathologically defined IBM (n = 24), tibial muscular dystrophy (n = 6), and histopathologically normal group (n = 9). In a comprehensive transcriptomics analysis, we analyzed the differential gene expression, differential splicing and exon usage, downstream pathway analysis, and the interplay between coding and non-coding RNAs (micro RNAs and long non-coding RNAs).

Results
We observe dysregulation of genes involved in calcium homeostasis, particularly affecting the T-cell activity and regulation, causing disturbed Ca2+-induced apoptotic pathways of T cells in IBM muscles. Additionally, LCK/p56, which is an essential gene in regulating the fate of T-cell apoptosis, shows increased expression and altered splicing usage in IBM muscles.

Interpretation
Our analysis provides a novel understanding of the molecular mechanisms in IBM by showing a detailed dysregulation of genes involved in calcium homeostasis and its effect on T-cell functioning in IBM muscles. Loss of T-cell regulation is hypothesized to be involved in the consistent observation of no response to immune therapies in IBM patients. Our results show that loss of apoptotic control of cytotoxic T cells could indeed be one component of their abnormal cytolytic activity in IBM muscles.