bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of serial C-reactive protein (CRP) measurements in hospitalized patients with bacteremia
Authors: Hanuka Aviv , Schwartz Yuval , Bdolah-Abram Tali , Assous Marc , Yinnon Amos , Munter Gavriel 
Published: December 2022

Abstract
Background: CRP is increasingly used as inflammatory marker in sepsis.
Aim of study: Assessment of the cost-effectiveness of CRP in the treatment of patients with bacteremia.
Methods: This was a retrospective study of two patient cohorts, one in 2015 (cohort A) and the other in 2018 (cohort B), each included 200 consecutively diagnosed patients with proven bacteremia. We assessed the following outcome markers: antibiotic use, duration of admission and in-hospital mortality.
Results: Baseline demographic and clinical data of the cohorts were similar. In cohort A, a single CRP test was obtained from 5% of the patients, while in cohort B, 95% of patients had CRP tests with a mean of 5.7 tests/person. Empiric, appropriate antibiotic treatment, increased from 72% in cohort A to 75% in cohort B (NS). Duration of antibiotic treatment did not change (10±8 days). The in-hospital mortality rate decreased from 38.5% in cohort A to 30.5% in cohort B (NS), as did mortality <7 days after diagnosis of bacteremia, from 17.5% to 14% respectively)(NS).
Conclusion: We found statistically insignificant differences between the cohorts. It is difficult to establish a causal relationship between the described changes and the widespread use of serial CRP tests. There is currently no evidence that supports serial use of CRP tests in the treatment of patients with bacteremia.
Internet Gaming Disorder and Mental Health in Pakistani youth: A Path Analysis with Impulsivity and Emotional Intelligence
Authors: Khalid Amna , Mukhtar Nadia 
Published: December 2022

Abstract
Background
Over the past decade the research on Internet gaming disorder IGD in youth has increased substantially due to its impact on young people’s mental health. One of the established risk factor of IGD is impulsivity. However, there is very little literature exploring its pathway of association with emotional intelligence leading to IGD especially in context of Pakistan.
Methods
We collected an online sample of 387 Pakistani, 15–24 years-olds who were involved in online gaming. Participants filled Barratt Impulsiveness Scale; BIS; WHO-5 wellbeing scale; Wong and Law Emotional Intelligence Scale (WLEIS) and Internet Gaming Disorder Scale–Short-Form (IGDS9-SF).
Results
The levels of IGD were high (58.9%) among youth involved in online gaming in Pakistan. We used Mplus to run path analysis showing that impulsivity partially mediates the association between emotional intelligence and IGD which then reduced wellbeing. Furthermore, impulsivity showed very strong association with IGD.
Conclusion
Interventions enhancing emotional intelligence among youth may account for some of the negative repercussions of impulsivity. There is need for further research in this area among youth from low and middle income countries to support the study findings. Association between IGD and participants background characteristics have also be discussed.
Combined use of voltage mapping and right ventriculography to guide ablation for arrhythmogenic right ventricular cardiomyopathy ventricular tachycardia：a case report
Authors: Yang Chengying , Liao Lei , Zeng Di , Liu Xiongtao , peng Chen , Wei Yan , Fan Xinrong 
Published: December 2022

Abstract
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial inherited cardiomyopathy associated with ventricular arrhythmias. With the development of molecular biology, histology, imaging, and other diagnostic techniques, the diagnosis rate and incidence of ARVC have gradually increased. However, ARVC remains rare in clinical practice. Currently, there is no specific treatment to eliminate arrhythmia. In this case report, we describe a clinical case of radiofrequency ablation in the treatment of ARVC with ventricular tachycardia and discuss the relevant literature.
Development and validation of a mobile application for graphical representation of pediatric urological anomalies: The Uro Map software
Authors: Ocáriz Rodrigo Campos , Miranda Márcio Lopes , Dias Ulisses Martins , Takei Danilo Yoiti , Pegolo Patrícia Traballi de Carvalho , Bustorff-Silva Joaquim Murray 
Published: December 2022

Abstract
Purpose:
The Uro Map application for smartphones was developed to help healthcare providers in the treatment of children with urological malformations, raising the possibility of graphically representing each urinary tract unit as an schematic illustration and associating it with relevant data from the patient’s medical history, producing an illustration representing the child’s urinary tract status that can be both archived and/or shared among caregivers. This app was submitted to a group of caregivers to test its accuracy and the results of this survey was the basis of the present report.
Methods:
Common pediatric urological situations were simulated through the application, generating ten images, which were attached to a form. For each figure, a multiple-choice question was assigned, with only one correct answer per question. The forms were sent to 875 Pediatric Surgeons and 400 Pediatric Nephrologists through their national scientific associations.
Results:
174 Pediatric Surgeons, 53 Pediatric Nephrologists, 18 Pediatric Surgery Residents, 26 urologists and 12 other healthcare providers answered the questionnaire. The latter 2 groups were formed due to the sharing of the form by the participants themselves. The mean score in each group was: pediatric surgeons 9.51, pediatric nephrologists 9.52, pediatric surgery residents 9.88, urologists 9.69 and other participants 8.8.
Conclusion:
The Uro Map application was successfully developed and based on the participants’ scores, it can be considered effective to represent the most diverse pediatric urological disorders.
End to End Delay Analysis of Dynamic Cooperative Spectrum Sensing Mechanism in IEEE 802.22 WRAN
Authors: Bino J , Bhuvaneswari P T V 
Published: December 2022

Abstract
IEEE 802.22 Wireless Regional Area Networks (WRAN) utilizes the Cognitive Radio dynamic spectrum access technique in TV bands. When allocating available spectrum to Secondary Users (SUs), in the absence of Primary Users (PUs), it is essential to ensure the Quality of Service (QoS) of SUs. The motivation behind this research is to devise a mechanism to ensure the QoS of SUs. The End to End delay (EED) experienced by SU through the devised mechanism need to be kept within the threshold suggested by WRAN standard. To achieve the above requirement, Dynamic Cooperative Spectrum Sensing (DCSS) is developed in this research. Two entities namely Spectrum Manager (SM) in Base Station (BS) and Spectrum Automation (SA) in SUs are engaged to realize them. They does the sensing of channel occupancy by the PUs. Further, a concept of Urgent Coexistence Situation (UCS) notification is issued by BS to indicate the re-arrival of PUs to SUs. Buffer mechanism is provisioned to restore the ongoing traffic of SUs until further resource allocation is accomplished. This strategy assures guaranteed data delivery of SUs traffic. However, this may introduce EED. Hence, this research investigates the performance of the developed DCSS mechanism in Netsim version 12 Simulator. The scenario with 1 Base Station, 3 PUs and 1 pair of SUs is constructed. Three different SUs traffic namely CBR, Voice and Video is considered. The impact of modulation schemes, occurrence of PUs traffic on average EED is analysed. From the simulation results, the modulation scheme that provides average EED within the threshold as per IEEE 802.22 is identified, thereby ensuring the QoS of the SUs.
Combustion regimes in turbulent non-premixed flames for space propulsion
Authors: Sanchis Daniel Martinez , Sternin Andrej , Haidn Oskar , Tajmar Martin 
Published: December 2022

Abstract
Direct numerical simulations of non-premixed fuel-rich methane-oxygen flames at 20 bar are conducted to investigate the turbulent mixing burning of gaseous propellants in rocket engines. The reacting flow is simulated using the EBI-DNS solver, within the OpenFOAM frame. The transport of species is resolved with finite rate chemistry, using a complex skeletal mechanism that entails 21 species. Two different flames at low and high Reynolds numbers are considered to study the sensitivity of the flame dynamics to turbulence. Regime markers are used to measure the probability of the flow to burning in premixed and non-premixed conditions at different regions. The local heat release statistics are studied to understand the drivers in the development of the turbulent diffusion flame. Despite the eminent non-premixed configuration, a significant amount of combustion takes place in premixed conditions. Premixed combustion is viable in both lean and fuel-rich regions, relatively far from the stoichiometric line. It is found that a growing turbulent kinetic energy is detrimental to combustion in fuel-rich premixed conditions. This is motivated by the disruption of the local premixed flame front, which promotes fuel transport into the diffusion flame. In addition, at downstream positions, higher turbulence enables the advection of methane into the lean core of the flame, enhancing the burning rates in these regions. Hence, the primary effect of turbulence is to increase the fraction of propellants burnt in oxygen-rich and near stoichiometric conditions. As a consequence, the mixture fraction of the products shifts towards lean conditions, influencing combustion completion at downstream positions.
How Low Can You Go? Broiler Breast Muscle Possesses a Mitochondrial Content of Just 2%
Authors: Soumeh Elham A. , Bottje Walter G. , Hudson Nicholas J. 
Published: December 2022

Abstract

In 1977 the pectoralis major (breast) muscle mitochondrial content of domestic broiler chickens, Gallus gallus domesticus, was estimated at 4.1%. This very low value is unsurprising in light of the bird’s unique muscle fibre composition, being exclusively composed of low aerobic capacity type IIB fibres. However, in the subsequent ~ 45 years broilers have been further modified by sustained intensive genetic selection on feed conversion efficiency and breast muscle mass. Objective With a view to understanding the metabolic implications of this historic selection – and also laying a foundation to better interpret current commercial performance - we quantitated the cellular bioenergetic structure of modern broilers. The breast muscle of 4 64 d old Ross308 broilers was subject to morphometric analysis based on transverse Transmission Electron Microscopy (TEM) images. Results This approach determined an average mitochondrial content, diameter and circularity ratio of 2.1%, 0.42 µm and 0.72, respectively. Broiler breast mitochondrial content has thus approximately halved in the last 45 years, and represents one of the lowest contents recorded for the muscle of any eukaryotic species. We have provided an updated benchmark for interpreting broiler muscle biochemistry and reinforce the view that domestic chickens are unique models of minimal aerobic capacity.
Glaucoma-related posts from a Chinese social media: An exploratory study
Authors: Fu Junxia , Yang Junrui , Li Qiuman , Huang Danqing , Yang Hongyang , Xie Xiaoling , Xu Huaxin , Zhang Mingzhi , Zheng Ce 
Published: December 2022

Abstract
Purpose: Our study aims to discuss glaucoma patients' needs and Internet habits using big data analysis and Natural Language Processing (NLP) based on deep learning (DL). We also developed and validated DL models to recognize social media data.
Methods: In this retrospective study, we used web crawler technology to crawl glaucoma-related topic posts from the glaucoma bar of Baidu Tieba. According to the contents of topic posts, we classified them into posts with or without seeking medical advice. Word Cloud and frequency statistics were used to analyze the contents and visualize the keywords. Two DL models, Bidirectional Long Short-Term Memory (Bi-LSTM) and Bidirectional Encoder Representations from Transformers (BERT), were trained to identify the posts seeking medical advice. The evaluation matrices included: accuracy, F1 value, and the area under the ROC curve (AUC).
Results: A total of 10,892 topic posts were included, among them, most were seeking medical advice (N=7071, 64.91%), and seeking advice regarding symptoms or examination (N=4913, 45.11%) dominated the majority, followed by searching for social support , expressing emotions, and sharing knowledge. The word cloud analysis showed that ocular pressure, visual field, examination, and operation were the most frequent words. The accuracy, F1 score, and AUC were 0.891, 0.891, and 0.931 for BERT model, 0.82, 0.821, and 0.890 for Bi-LSTM model.
Conclusion: Social media can help enhance the patient-doctor relationship by providing patients’ concerns and cognition about glaucoma. DL models performed well in classifying Chinese medical-related texts, which could play an important role in public health monitoring.
Experimental study on disaster mechanism of completely weathered granite landslide induced by extreme rainfall
Authors: Liu Honghua , Yu Peng , Lu Haitao , Xie Yongjian , Wang Zhongsheng , Hao Shengyou , Liu Hongjun , Fu Yunxia 
Published: December 2022

Abstract
With the increased frequency of extreme weather, landslides induced by extremely heavy rainfall pose a major threat to human lives and property safety. Taking the 7.23 Fanling landslide in Laoshan, Qingdao, a typical strongly weathered granite area, as an example, based on the similarity criterion, three groups of indoor model tests under different extreme rainfall conditions were conducted using a large landslide model test box. The rainfall infiltration responses under different rainfall intensities, deformation processes, and failure modes of the slope were analyzed. The inducing mechanism and rainfall disaster process of granite landslides induced by extreme rainfall in strongly weathered areas were summarized. The results showed that (1) a completely weathered granite landslide induced by rainfall had four stages, i.e., infiltration erosion, surface deformation, damage deepening, and overall instability, and the slope was characterized by "sheet slip". (2) With greater rainfall intensities, the rainfall infiltration rate was higher, the changes in soil pressure, pore water pressure, water content, and matrix suction were faster, and the hysteresis effect was weaker. (3) A certain spatial distribution pattern was observed between slope deformation/damage and rainfall infiltration, and the research results could provide references for landslide warning and treatment in strongly weathered granite areas.
Spontaneous Intracerebral Haemorrhage Secondary to 5-ALA-induced Thrombocytopaenia in a Paediatric Patient: Case Report and Literature Review
Authors: Mui Olivia , Murray Daniel B , Walsh Bill , Crimmins Darach W , Caird John D 
Published: December 2022

Abstract
Introduction
The primary objective of neurosurgical management of malignant gliomas is maximal safe resection of the tumour. One of the main obstacles in achieving this is the ability to accurately discriminate between tumour edges and the surrounding healthy brain tissue. The use of fluorescence-guided surgery utilising 5-aminolevulinic acid (5-ALA), first introduced more than twenty years ago, has become an invaluable adjunct in high-grade glioma surgery in adults. However, as 5-ALA is not licensed for use in paediatric patients, the safety profile for such use remains undetermined.
Case Report
We describe the case of a four year-old boy who underwent 5-ALA-guided resection of a fourth ventricle anaplastic ependymoma. Although complete resection was achieved and the patient awoke from surgery well with no neurological deficits, the patient developed acute transaminitis, anaemia, thrombocytopaenia and coagulopathy post-operatively. The patient had a sudden neurological deterioration on post-operative day two; imaging revealed that he had suffered a spontaneous right frontal intracerebral haemorrhage. The patient returned to theatre for surgical decompression and evacuation of the haematoma, and ultimately went on to make a full recovery.
Conclusion
The use of 5-ALA in paediatric patients can be helpful in maximising surgical resection, but the associated safety profile remains undefined. Further research is urgently warranted in order to characterise the efficacy and risk of the use of 5-ALA in the paediatric population.
New method for the isotopic study of ancient conchiolin from archaeological shells of freshwater mussels (Unionoida)
Authors: García-Vázquez Ana , Radu Valentin , Lazăr Cǎtǎlin 
Published: December 2022

Abstract

Freshwater mussels shells are common remains in archaeological sites of the Gumelnița culture (5th millennium BC, Romania), and were part of the diet of its ancient inhabitants. The proteins of these shells are often preserved and can be used for paleodietary and paleoecosystem reconstructions by stable isotopes. To obtain the empirical relationship between the isotopic composition of sell organic matrix and soft tissues, we analysed the body (foot and mantle), the muscle, the conchiolin of the shell and stomach contents of modern individuals of Unio tumidus from the Danube. In addition, modern shells were digested in 5M HCl and archaeological in 1M HCl to obtain the shell organic matrix or conchiolin. We established a quality criterion for freshwater mussel shell conchiolin of 3.6 (± 0.3) for the C:N and obtained an offset of Δ15Nconchiolin−defatted body = + 0.95‰, Δ13Cconchiolin−defatted body = + 0.93‰ for the soft tissues, and an offset of Δ15Nconchiolin−muscle = + 1.7‰, Δ13Cconchiolin−muscle = + 0.3‰ for the muscle. Freshwater mussels from Gumelnița showed that they came from different sources (rivers, lakes, ponds…) but which not necessarily have to come from long distances since all these different habitats were present in the vicinity of the site.
Emoji-based Opinion Mining using Deep Learning Techniques
Authors: Pathan Azizkhan F , Prakash Chetana 
Published: December 2022

Abstract
Informal media, such as Twitter, are more relevant today than ever before. Twitter is still a valuable tool for friends to communicate, but it has evolved into a public bulletin board where ordinary people, companies, and even big personalities like politicians and sports routinely publish their thoughts and participate in conversations. Since, Twitter is so extensively utilized throughout the world, the ability to do reliable opinion mining and gauge public opinion and perception on a variety of issues is more vital than ever. Emojis are frequently used to communicate feelings or sentiments that are difficult to express succinctly in language. For emoji-based opinion mining, a deep learning framework is presented to model the influence of emojis on text sentiment polarity. The emojis and words in microblog posts are combined to create emoji representations that include contextual information.
Embolic microspheres for transarterial chemo-embolization (TACE) featuring inherent radiopacity and carrying crystalline drugs at their surface, in dimples or inside major cavities
Authors: Koole Leo H. , Shen Meitong 
Published: December 2022

Abstract
Transarterial chemoembolization (TACE) using drug-eluting embolic (DEE) microparticles is a minimally invasive treatment technique that finds more and more applications in oncology, particularly in the treatment of patients with hepatocellular carcinoma. The last decade has seen marked developments in TACE, mainly due to innovations regarding the embolic microparticles. We studied a new versatile approach for charging TACE embolic particles (3D-crosslinkled polymer microspheres) with crystalline (cytostatic) drugs. The crystals are physically attached to the microporous particles. This approach provides a promising alternative for the ion-exchange regime that underlies the mechanism of action of all TACE/DEE products which are currently available commercially. Moreover, chemical synthesis is reported of new nearly spherical polymeric microparticles which either have a cavity or one or more dimples in their surface. These particles are remarkable since (i), the cavity or dimples can accommodate relatively large drug crystals in a stable manner, and (ii), their size is 1–2 orders of magnitude larger than similar shapes known in the literature. The large diameter (ranging from 200 to 600 µm roughly) renders the new particles suitable for TACE/DEE. It is argued and underpinned that the use of crystalline drug formulations according to this methodology can open new possibilities for TACE in the treatment of different solid cancers, particularly since (i), larger drug payloads can be achieved, and (ii), new options emerge to use lipophilic crystalline drugs which have been incompatible with TACE hitherto. Since many potent cytostatic medicines fall into this category, the new technique can likely become scope-widening for the TACE technique.
Novel quantitative trait locus qSDR3.1 represses Oryza sativa. L seed dormancy
Authors: Guo Naihui , Tang Shengjia , Wang Yakun , Chen Wei , An Ruihu , Ren Zongliang , Hu Shikai , Tang Shaoqing , Wei Xiangjin , Shao Gaoneng , Jiao Guiai , Xie Lihong , Wang Ling , Chen Ying , Zhao Fengli , Sheng Zhonghua , Hu Peisong 
Published: December 2022

Abstract
Preharvest sprouting (PHS), a deleterious phenotype that occurs frequently in rice growing regions with high temperature and precipitation, negatively affects yield, quality, and processing. Seed dormancy can prevent PHS. We report discovery of qSDR3.1, a new quantitative trait locus (QTL) for seed dormancy in rice. knockout lines of qSDR3.1 exhibited significant reduction in PHS. The qSDR3.1 locus negatively regulated seed dormancy by directly inhibiting the transcriptional activity of ABSCISIC ACID INSENSITIVE5 (ABI5). Haplotype analysis showed that qSDR3.1 was divided into five haplotypes and three amino acid (aa) types. The 102nd (aa102) and 105th (aa105) amino acids of qSDR3.1 were the key amino acids responsible for the differences in dormancy between Xian and Geng. Genetic diversity analysis revealed that qSDR3.1 was artificially selected during domestication. We proposed a two-line model for the process of rice dormancy domestication from wild rice to Xian and Geng, and we provide new candidate genes and germplasm for genetic improvement of rice seed dormancy.