bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of AS04‐HPV‐16/18 vaccine in Chinese women aged 26 years and older and long‐term protective effect in women vaccinated at age 18–25 years: A 10‐year follow‐up study
Authors: Zhao Fanghui , Jastorff Archana , Hong Ying , Hu Shangying , Chen Wen , Xu Xiaoqian , Zhu Yejiang , Zhu Jiahong , Zhang Xun , Zhang Wenhua , Xu Dacheng , Wang Dali , Tang Rong , Sun Yonghong , Shen Yiping , Pan Qinjing , Yin Jian , Liu Daokuan , Liu Bin , Karkada Naveen , Jiang Chunmei , Cui Jianfeng , Chen Feng , Bi Jun , Bao Yuqing , Zhou Xin , Cartier Cyrille , Hu Yuemei , Borys Dorota 
Published: September 2022

AbstractIntroductionThe pivotal efficacy study assessed efficacy and safety of GSK's AS04‐HPV‐16/18 vaccine in Chinese women aged 18–25 years up to 6 years. The present extension study, performed 4 years later, offered AS04‐HPV‐16/18 vaccination to placebo recipients. Vaccine safety and its long‐term protective effect were assessed at Year 10.MethodsAll 6051 women who received AS04‐HPV‐16/18 or the placebo during the initial study (NCT00779766) were invited to phase III/IV, open‐label, partially controlled extension Year 10 study (NCT03629886). Placebo recipients were offered three‐dose AS04‐HPV‐16/18 vaccination and followed up over 12 months to assess the safety. Cervical samples from all women were examined. Vaccine efficacy (VE) against incident infections and cytological lesions associated with HPV‐16/18 and other oncogenic types was assessed as exploratory objective.ResultsAmong 3537 women (out of 6051) enrolled in the extension study, 1791 women (mean age 32.7 years; standard deviation 1.8 years) received AS04‐HPV‐16/18 and reported no serious adverse events, potential immune‐mediated diseases, or adverse pregnancy outcomes related to vaccination. Among 6051 women, VE against incident HPV‐16, ‐18, and ‐16/18 infections up to Year 10 was 82.8% (95% confidence interval: 72.5–89.7), 79.8% (64.5–89.2), and 80.8% (72.4–87.0), respectively. VE against HPV‐16/18 ASC‐US+, CIN1+, and CIN2+ was 92.7% (82.2–97.7), 94.8% (67.4–99.9), and 90.5% (34.6–99.8), respectively.ConclusionAS04‐HPV‐16/18 vaccine showed an acceptable safety profile in Chinese women vaccinated at age 26 years or above, and a long‐term protection similar to other efficacy trials worldwide.
Isoniazid level and flu‐like symptoms during rifapentine‐based tuberculosis preventive therapy: A population pharmacokinetic analysis
Authors: Lee Ming‐Chia , Fujita Yuito , Muraki Shota , Huang Hung‐Ling , Lee Chih‐Hsin , Wang Jann‐Yuan , Ieiri Ichiro 
Published: September 2022

AimA population pharmacokinetic (PPK) study of the correlation of adverse drug reactions (ADRs) with the 3HP regimen (weekly high‐dose rifapentine plus isoniazid for 12 doses) for latent tuberculosis infection (LTBI) remains lacking. The purpose of this study is to determine the association of rifapentine or isoniazid concentration and ADRs.MethodsThis prospective, multicentre, observational study enrolled LTBI contacts receiving 3HP treatment between January 2017 and August 2020. The concentrations of rifapentine, isoniazid and their metabolites (25‐desacetyl‐rifapentine and acetyl‐isoniazid) in plasma samples collected monthly after 3HP treatment were determined. A PPK model was constructed to predict the maximum concentration (Cmax) and area under the concentration–time curve from 0 to 24 h (AUC). Their association with ADRs was evaluated by applying three multivariate logistic regression models with adjustment for various covariates.ResultsA total of 415 LTBI cases were ultimately enrolled; 355 (85.5%) completed the 3HP treatment. Among them, 47 (11.3%) experienced systemic drug reactions and 291 (70.0%) experienced one or more flu‐like symptom. The plasma concentration–time profiles of isoniazid, rifapentine and their metabolites were adequately described by the developed models. A higher Cmax of isoniazid was significantly correlated with a higher risk of any ADR (adjusted odds ratio and 95% confidence interval: 3.04 [1.07–8.65]) and any or at least two flu‐like symptoms (all severity grades) (2.76 [1.06–7.17]).ConclusionsIsoniazid may be responsible for ADRs, especially flu‐like symptoms, during 3HP treatment.
Safety of off‐label dose reduction of non‐vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
Authors: van den Dries Carline J. , Pajouheshnia Romin , van den Ham Hendrika A. , Souverein Patrick , Moons Karel G. M. , Hoes Arno W. , Geersing Geert‐Jan , van Doorn Sander 
Published: September 2022

AimTo investigate the effects of off‐label non‐vitamin K oral anticoagulant (NOAC) dose reduction compared with on‐label standard dosing in atrial fibrillation (AF) patients in routine care.MethodsPopulation‐based cohort study using data from the United Kingdom Clinical Practice Research Datalink, comparing adults with non‐valvular AF receiving an off‐label reduced NOAC dose to patients receiving an on‐label standard dose. Outcomes were ischaemic stroke, major/non‐major bleeding and mortality. Inverse probability of treatment weighting and inverse probability of censoring weighting on the propensity score were applied to adjust for confounding and informative censoring.ResultsOff‐label dose reduction occurred in 2466 patients (8.0%), compared with 18 108 (58.5%) on‐label standard‐dose users. Median age was 80 years (interquartile range [IQR] 73.0‐86.0) versus 72 years (IQR 66‐78), respectively. Incidence rates were higher in the off‐label dose reduction group compared to the on‐label standard dose group, for ischaemic stroke (0.94 vs 0.70 per 100 person years), major bleeding (1.48 vs 0.83), non‐major bleeding (6.78 vs 6.16) and mortality (10.12 vs 3.72). Adjusted analyses resulted in a hazard ratio of 0.95 (95% confidence interval [CI] 0.57‐1.60) for ischaemic stroke, 0.88 (95% CI 0.57‐1.35) for major bleeding, 0.81 (95% CI 0.67‐0.98) for non‐major bleeding and 1.34 (95% CI 1.12‐1.61) for mortality.ConclusionIn this large population‐based study, the hazards for ischaemic stroke and major bleeding were low, and similar in AF patients receiving an off‐label reduced NOAC dose compared with on‐label standard dose users, while non‐major bleeding risk appeared to be lower and mortality risk higher. Caution towards prescribing an off‐label reduced NOAC dose is therefore required.
How do students' self‐regulation skills affect learning satisfaction and continuous intention within desktop‐based virtual reality? A structural equation modelling approach
Authors: Liu Zheyu , Yu Ping , Liu Jiale , Pi Zhongling , Cui Weijin 
Published: September 2022

AbstractVirtual reality, as an excellent supportive instructional technology, has gained increasing attention from educators and professionals, where desktop‐based virtual reality (DVR) is broadly adopted due to its affordability and accessibility. However, when evaluating students' learning experiences such as flow experiences in DVR environments, most studies adopt a single construct (the total score of flow experience) rather than multiple constructs (enjoyment, engagement, concentration, presence and time distortion). This study implemented desktop‐based virtual reality for a STEM bridge designing program with a total of 254 undergraduates to investigate the relationship between self‐regulation skills, five dimensions of flow experience, learning satisfaction and continuous intention when engaging in a DVR learning environment. The results revealed that self‐regulated learning exerted a dominant impact on students' learning attitudes in DVR learning, in which students' flow experience had a significant mediating effect. Notably, although DVR exhibited poor time distortion, higher satisfaction and continuous intention were still predicted by the mentality of flow experience (ie, enjoyment, engagement, concentration and presence). The findings of this study contribute to the consideration of learning experiences and attitudes, which has insights for the future design of desktop‐based virtual reality environments and related instructional activities.
Practitioner notesWhat is already known about this topic

Students are different in self‐regulation skills, which influences their satisfaction and continuous intention in learning.
Students' self‐regulation skills are one of the important variables in predicting their flow experience.
A high level of flow experience contributes to a coherent and efficient learning experience within desktop‐based virtual reality (DVR) environments.
What this paper adds

Students' self‐regulation skills positively predicted their flow experience and satisfaction in DVR environments.
The components of flow experience (enjoyment, concentration and presence) partially mediated the relationship between self‐regulation skills and satisfaction.
Students' self‐regulation skills indirectly affect continuous intention by the enjoyment and engagement of flow experiences.
Implications for practice and/or policy

When delivering DVR‐based learning activities educators should be supportive of students with low levels of self‐regulation skills.
Emphasis on promoting flow experiences such as enjoyment, engagement, concentration and presence in designing a DVR‐based classroom could enhance student satisfaction and continuous intention.
Embedding scaffolding or feedback in DVR settings would support self‐regulated learning and subsequently improve student satisfaction and persistence through enhanced flow experience.
Intravenous immunoglobulin in the management of severe early onset red blood cell alloimmunisation
Authors: Vlachodimitropoulou Evangelia , Lo Tsz Kin , Bambao Clarissa , Denomme Greg , Seaward Gareth R. , Windrim Rory , Tessier Francine , Kelly Edmond , Van Mieghem Tim , Ryan Greg 
Published: September 2022

SummaryOur objective was to assess the effect of maternal intravenous immunoglobulin (IVIG) administration for severe red blood cell (RBC) alloimmunisation on fetal outcomes. This is a case–control study. Women with a history of severe early onset alloimmunisation resulting in fetal loss in a previous pregnancy and high anti‐D or anti‐K antibody titres received IVIG in a subsequent pregnancy. We assessed gestational age at first transfusion and fetal outcomes in the subsequent pregnancy and compared these with the outcomes in the previous pregnancy. The most responsible antibody was anti‐D in 17 women and anti‐K in two others, whilst seven had more than one antibody. In all, 19 women received IVIG in 22 pregnancies, two of which did not even need an intrauterine transfusion (IUT). For previous early losses despite transfusion, IVIG was associated with a relative increase in fetal haemoglobin between treated and untreated pregnancies of 36.5 g/L (95% confidence interval 19.8–53.2, p = 0.0013) and improved perinatal survival (eight of eight vs. none of six, p = 0.001). For previous losses at <20 weeks, it enabled first transfusion deferral in subsequent pregnancies to at least 19.9 weeks (mean 23.2 weeks). Overall, IVIG decreases the severity of haemolytic disease of the fetus and newborn and allows deferral of the first IUT to a safer gestation in severe early‐onset RBC alloimmunisation and rarely may even avoid the need for IUT entirely.
Crickets as indicators of ecological succession in tropical systems, New Caledonia
Authors: Anso Jeremy , Gasc Amandine , Bourguet Edouard , Desutter‐Grandcolas Laure , Jourdan Hervé 
Published: September 2022

AbstractCrickets (Ensifera, Grylloidea) are not commonly used as ecological indicators in contrary to other Orthoptera (e.g., grasshoppers and katydids). However, they are sensitive to environmental changes and abundant in tropical regions. To evaluate whether crickets are relevant bioindicators of tropical ecosystems, we investigated cricket assemblages along a tropical ecological gradient. We collected crickets during both day and night in southern New Caledonia for three stages of ecological succession: open shrubland, preforest, and forest. Simultaneously, we measured several environmental variables, such as temperature and relative humidity, at each sampling site. Cricket species assemblages showed a clear response to ecological succession. The highest and lowest species richness and abundances of individuals were, respectively, found in forest and shrubland, with species specialized in each ecological stage revealing the conservation value of each of these stages. Similar results were found when considering only the part of cricket communities with the ability to acoustically communicate. This work is part of a larger research program about Neocaledonian crickets and contributes to support the use of acoustic approaches to monitor tropical environments. In conclusion, these findings highlight the potential value of crickets as an environmental indicator in tropical ecosystems. The results also contribute to the discussion of the intrinsic conservational value of shrublands in New Caledonia and similar ecotypes.Abstract in French is available with online material.
Detection and genetic variation analysis of apple chlorotic leaf spot virus and apple stem grooving virus in wild apple (Malus sieversii) from Xinjiang, China
Authors: Jia Xiao‐Jun , Zhang Zun‐Ping , Fan Xu‐Dong , Ren Fang , Dong Ya‐Feng , Hu Guo‐Jun 
Published: September 2022

AbstractHere, we produced nucleotide and amino acid sequences of the movement protein (MP) and the coat protein (CP) genes of apple chlorotic leaf spot virus (ACLSV) and apple stem grooving virus (ASGV) from wild apple of Xinjiang, the main progenitor of the domesticated apple. Genetic variation and phylogenetics were assessed using these and previously reported sequences. Phylogenetic analysis of ACLSV nucleotide and amino acid data sets assigned some ACLSV variants to known groups and others to novel clades. In an MP‐based phylogenetic tree, ASGV sequences downloaded from GenBank and those of wild apple isolates were assigned to separate groups. A recombinant sequence was identified in a ACLSV variant (MS‐GL‐1‐c‐3) of wild apple, and both parents of the recombinant had been isolated from the same plant (GL). Two potential recombination events of ASGV (MS‐GL‐2‐g‐3 and MS‐NF‐1‐g‐3) were identified in this study. These findings may constitute a valuable basis for future studies on variability of virus genetics and pathogenicity.
Review of glucocorticoid therapy in horses: Intra‐articular corticosteroids
Authors: Boorman Sophie , McMaster Mattie A. , Groover Erin , Caldwell Fred 
Published: September 2022

SummaryThis is the third article in a review series on the use of glucocorticoids to treat medical and musculoskeletal conditions in horses. This article in the series reviews the use of corticosteroids in the treatment of osteoarthritis and includes an appraisal of the most commonly used corticosteroids in equine practice. The regulatory rules concerning the use of corticosteroids are discussed, along with incidence, diagnosis and treatment of possible complications relating to intra‐articular therapy.
RETRACTED: Natural language processing with deep learning enabled hybrid content retrieval model for digital library management
Authors: Ragab Mahmoud , Almuhammadi Anas , Mansour Romany F. , Kadry Seifedine 
Published: September 2022

AbstractIn recent times, natural language processing (NLP) technique has received significant attention in content retrieval (CR) domain. The emergence of digital libraries, in recent years, enables people from across the globe to access and store books, documents, and literature of multiple kinds. The development of NLP models has considerably improved the performance in terms of digital library management. In this scenario, artificial intelligence‐based expert systems are required to handle massive quantities of data that exist in digital libraries and achieve effective CR performance. In this background, the current study designs NLP with deep learning enabled hybrid content retrieval (NLPDL‐HCR) model for digital library management. The aim of the presented NLPDL‐HCR is to effectually retrieve the images as well as textual data from digital libraries based on a user's query. The proposed NLPDL‐HCR model encompasses two major stages namely, text retrieval and image retrieval (IR). During text retrieval process, the proposed NLPDL‐HCR model includes term frequency inverse document frequency vectorizer with optimal gated recurrent unit (GRU) model. The hyperparameters of the GRU model are optimally adjusted with the help of RMSProp approach. Besides, the IR process involves three sub‐processes namely, densely connected networks‐based feature extraction, butterfly optimization algorithm‐based hyperparameter tuning, and Euclidean distance‐based similarity measurement. The experimental analysis results, accomplished by the proposed NLPDL‐HCR model using benchmark datasets, highlighted its superior performance over recent state‐of‐the‐art approaches.
Inhibition of kidney potassium channels by fluoxetine: In vivo and in vitro studies
Authors: Vieira‐Coelho Maria A. , Martel Fátima 
Published: September 2022

AbstractIn vitro studies have demonstrated that fluoxetine, a commonly used antidepressant drug, can modulate the activity of K+ channels. In the present study, we investigated the in vivo effect of acute and sub‐chronic treatment of rats with fluoxetine on K+ renal transport. Furthermore, OK cells, a kidney epithelial cell line, were used in order to evaluate the in vitro effect of fluoxetine on K+ currents. In the sub‐chronic study, fluoxetine was administrated daily (10 mg/kg, p.o.) for 15 days to male adult Wistar rats. In the acute study, rats were given increasing doses of fluoxetine (1, 3, 10, 30 and 50 mg/kg, p.o.) for 24 h.Results from the sub‐chronic study show that urinary K+ content (in mmol/L) was markedly reduced in the fluoxetine‐treated animals (fluoxetine: 83 ± 9; control: 131 ± 10; P < 0.001). K+ fractional renal excretion (in %) was also significantly lower in the fluoxetine group (fluoxetine: 6 ± 1; control: 13 ± 2; P < 0.001). No significant changes was observed in creatinine clearance and on renal tubular Na+,K+‐ATPase activity. Results obtained from the acute study demonstrate that, after a 24‐h administration, fluoxetine produced a dose‐dependent decrease in urinary K+, with an ED50 (in mg/kg) of 4.2 (2.8; 5.5) and a maximal effect of 62% reduction. In vitro, fluoxetine produced a concentration‐dependent inhibition of K+ currents in OK cells, with an EC50 of 107 (84.8; 129.5) μM. In conclusion, fluoxetine produces a marked reduction on urinary K+ excretion; this effect constitutes an in vivo evidence for the inhibitory action of fluoxetine on kidney epithelial K+ channels.
Avoiding growing pains in reproductive trait databases: the curse of dimensionality
Authors: Ginther Samuel C. , Cameron Hayley , White Craig R. , Marshall Dustin J. 
Published: September 2022

AbstractAimReproductive output features prominently in many trait databases, but the metrics describing it vary and are often untethered to temporal and volumetric dimensions (e.g., fecundity per bout). The use of such ambiguous reproductive measures to make broad‐scale comparisons across taxonomic groups will be meaningful only if they show a 1:1 relationship with a reproductive measure that explicitly includes both a volumetric and a temporal component (i.e., reproductive mass per year). We sought to map the prevalence of ambiguous and explicit reproductive measures across taxa and to explore their relationships with one another to determine the cross‐compatibility and utility of reproductive metrics in trait databases.LocationGlobal.Time period1990–2021.Major taxa studiedWe searched for reproductive measures across all Metazoa and identified 19,785 vertebrate species (Chordata), and 440 invertebrate species (Arthropoda, Cnidaria or Mollusca).MethodsWe included 37 databases, from which we summarized the commonality of reproductive metrics across taxonomic groups. We also quantified scaling relationships between ambiguous reproductive traits (fecundity per bout, fecundity per year and reproductive mass per bout) and an explicit measure (reproductive mass per year) to assess their cross‐compatibility.ResultsMost species were missing at least one temporal or volumetric dimension of reproductive output, such that reproductive mass per year could be reconstructed for only 4,786 vertebrate species. Ambiguous reproductive measures were poor predictors of reproductive mass per year; in no instance did these measures scale at 1:1.Main conclusionsAmbiguous measures systematically misestimate reproductive mass per year. Until more data are collected, we suggest that researchers should use the clade‐specific scaling relationships provided here to convert ambiguous reproductive measures to reproductive mass per year.
Patient‐related outcomes and Oral Health‐Related Quality of Life in endodontics
Authors: Doğramacı Esma J. , Rossi‐Fedele Giampiero 
Published: September 2022

AbstractThere is increased interest in outcome measures that complement the classic goal of endodontics, being the prevention and healing of apical periodontitis. Possible outcome measures can be subdivided into patient‐centred outcomes (PCOs), encompassing data collected by nonpatients aiming to assess the effectiveness of an intervention and patient‐reported outcomes (PROs), which are reported directly by the patient. PROs can be subsequently classed into PRO measures that ascertain patients' view of their symptoms, their functional status, and their health‐related quality of life, and patient‐reported experience measures that focus on aspects including the humanity of care, patient satisfaction, patient preference and adherence, personal costs, expectation fulfilment, and decision regrets. The present review aims to define various patient‐related outcomes and discuss the literature available regarding PCOs and PROs in endodontics. This includes those proposed to assess the effectiveness of endodontic treatment for pulpitis and apical periodontitis for use in the development of European Society of Endodontology S3‐level clinical practice guidelines that have been included by all working groups, except for the radiographic assessment of apical periodontitis. Based on limited evidence in the field, it can be summarized that after recall periods of various lengths, endodontic treatment is associated with a high likelihood of tooth survival and limited need for further intervention, including extraction and further restorative procedures. Oral Health‐Related Quality of Life (OHRQoL) is likely to improve following the completion of treatment. Nonetheless, the literature assessing the association between OHRQoL and endodontics is hampered by the use of instruments that have not been previously validated. Amongst the remaining outcome measures discussed in the present review, it is worth highlighting that there is only one study assessing exacerbations in teeth with the presence of endodontic pathosis, which suggests a very low incidence of this adverse effect following endodontic treatment. Patients' expectation fulfilment, adherence, and satisfaction are closely inter‐related and depend also on various nonclinical factors. Further studies assessing PCOs and PROs, in association with healing and prevention of apical periodontitis, are required to better understand endodontic treatment from the perspective of patients.