bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Use of Chitosan-PGLA Nerve Grafts and Bone Marrow Mononuclear
Cells to Repair a 50-mm-long Median Nerve Defect Combined
with an 80-mm-long Ulnar Nerve Defect in the Human Upper Arm
Authors: Gu Xiaokun , Yi Sheng , Deng Aidong , Liu Hong , Xu Lai , Gu Jianhui , Gu Xiaosong 
Published: April 2022

Background:
Severe peripheral nerve injury, especially the long-distance peripheral nerve
defect, causes severe functional disability in patients. There is always a lack of effective repair methods
for clinic, and those in practice are associated with side effects. A case study was performed to observe
the regenerative outcomes of the surgical repair of long-distance peripheral nerve defects in the upper arm
with chitosan-poly(glycolide-co-lactide) (PGLA) nerve grafts combined with bone marrow mononuclear
cells (BMMCs).

Methods:
The right upper arm of a 29-year-old woman was injured, leaving a 50-mm-long median nerve
defect, an 80-mm-long ulnar nerve defect, and muscle and blood vessel disruptions. The nerve defects
were repaired by implanting BMMC-containing chitosan-PGLA nerve grafts on the 40th day after injury.
A series of functional assessments were carried out from 2 weeks to 66 months after surgical repair. Sensory
function was assessed by the pinprick test, two-point discrimination test and Semmes-Weinstein
monofilament test. Motor function was evaluated by the range of motion of the wrist joint and muscle
power. Autonomic function was monitored by laser-Doppler perfusion imaging (LDPI). Tissue morphology
was observed through ultrasonic investigations.

Results:
No adverse events, such as infection, allergy, or rejection, caused by the treatment were detected
during the follow-up period. Sensory and pinprick nociception in the affected thumb, index, and middle
fingers gradually restored at 6th month after surgery. The monofilament tactile sensation was 0.4 g in the
terminal finger pulp of the thumb and index finger, 2.0 g in the middle finger, and greater than 300 g in
the ring finger and little finger at the 66th month. Motor function recovery was detected at the 5th month
after surgery, when the muscle strength of the affected forearm flexors began to recover. At the 66th
month after surgery, the patient's forearm flexor strength was grade 4, with 80° of palmar flexion, 85° of
dorsal extension, 8° of radial deviation, 40° of ulnar deviation, 40° of anterior rotation, and 85° of posterior
rotation of the affected wrist. The patient could perform holding, picking up, and some other daily
activities with the affected hand. The patient's sweating function of the affected hand was close to the
level of the healthy hand. LDPI showed that the skin blood flow perfusion was significantly increased,
with perfusion similar to on the normal side in some areas. Neuromusculoskeletal ultrasonography
showed the presence of nerve structures.

Conclusions:
These results suggest that chitosan-PGLA nerve grafts combined with BMMCs could effectively
repair long-distance nerve defects and achieve good clinical results.
A Full-Dimensional ab initio Intermolecular Potential Energy Surface and
Dipole Moment Surfaces for H2O-Ar
Authors: Liu Qiong , Wang Junyan , Zhou Yanzi , Xie Daiqian 
Published: April 2022

Background:
The H2O–Ar system has attracted significant interest in recent years because
it is an important model to study inelastic scattering between atoms and triatomic molecules.
A high-accuracy intermolecular potential energy surface (IPES) is the foundation for theoretical
study on molecular collision dynamics for H2O–Ar. In addition, dipole moment surfaces (DMSs) are
one of the prerequisites for spectral simulation.

Objective:
This study aimed to obtain a full-dimensional intermolecular potential energy surface and
dipole moment surfaces for the van der Waals complex H2O–Ar.

Methods:
In this study, ab initio energy points were computed at the frozen-core (FC) explicitly
correlated coupled-cluster [FC-CCSD(T)-F12a] level, with the augmented correlation-consistent
polarized valence quadruple-zeta basis set plus bond functions. The permutation invariant polynomial
neural network (PIP-NN) approach is adopted to fit the IPES, while the DMSs are constructed
at the MP2/AVTZ level and fitted by the NN approach.

Results:
With a root-mean-square-error (RMSE) of 0.284 cm-1, the IPES can accurately describe the
motion of the H2O–Ar complex between R = 4 and 20 a0 in the energy range up to 10000 cm-1. The
fitting errors of all the data points are 6.192 and 6.509 mDebye for the X and Z components, respectively.
The global minimum of -140.633 cm-1 has the plane geometry, while the dipole moment of
H2O–Ar is 1.853 Debye at the equilibrium structure.

Conclusion:
In summary, we report a full-dimensional intermolecular potential energy surface for
H2O–Ar. The IPES precisely reproduces CCSD(T)-F12a electronic energies with a large basis set.
The corresponding dipole moment surfaces have also been reported. In comparison with previous
work, the employment of the high-level ab initio method will make our IPES more reliable. Several
typical 2D contour plots of the IPES and DMSs are also shown. The argon atom has a weak effect
on the dipole moment of the H2O–Ar complex. The FORTRAN codes to generate 6D potentials and
dipole moments reported here are available on request from the authors.
Petrología y geoquímica de los Ortoneises aflorantes en los sectores central y este en el Macizo de Santander, Andes Colombianos
Authors: García-Ramírez Carlos Alberto , Rey-León Vanessa 
Published: April 2022

Los Ortoneises aflorantes en los sectores central y este en el Macizo de Santander, consisten en intercalaciones de neis hornbléndico, neis biotítico y neis cuarzo–feldespático, predominando las dos primeras variedades. En estos ortoneises aparecen lentes esporádicos de anfibolita. Los ortoneises son el resultado del emplazamiento sintectónico de granitoides en rocas de los Esquistos del Silgará, durante el pico metamórfico de esta unidad metasedimentaria. Se observan algunas diferencias estructurales y composicionales en los ortoneises de los sectores central y este; la foliación más desarrollada, se observa en el sector central y la presencia de moscovita, al parecer se restringe solo al sector este. Las características geoquímicas evidencian que los ortoneises del sector central son de composición granítica, mientras que, para los ubicados en el sector este, su composición varía entre granito y granodiorita. Estos ortoneises fueron formados en una margen continental activa. El contenido de Tierras raras (REE) en los ortoneises evidencian tres patrones diferentes de comportamiento: 1) Los ortoneises félsicos muestran un paulatino empobrecimiento en las REE ligeras (La–Sm) y un empobrecimiento en REE pesadas (Eu–Lu); 2) ortoneises con clara anomalía negativa en Eu* y 3) La anfibolita está muy empobrecida en REE ligeras y va incrementando el contenido de REE pesadas con ausencia de anomalía en Eu*. Las condiciones P–T de metamorfismo para los ortoneises del sector central fueron: T = 690–770 °C y P = 0.53–0.85 GPa, mientras que, en el este, la temperatura obtenida varía entre 680 y 693 °C. La ocurrencia, relaciones de campo entre los ortoneises estudiados con unidades metasedimentarias y las edades, son muy similares a la de los ortoneises aflorantes a lo largo de los Andes y el sureste de México, evidenciando un arco magmático desarrollado a lo largo del protomargen de Gondwana Occidental.
Un conjunto de foraminíferos planctónicos del Aptiano tardío y framboides de pirita provenientes del “Otates Horizon”, Cerro Boludo, Hidalgo, México: implicaciones peleoecológicas y paleoambientales
Authors: Omaña Lourdes , López-Caballero Iriliana , Nuñez-Useche Fernando 
Published: April 2022

Los depósitos carbonatados del Cretácico están ampliamente distribuidos a lo largo del cinturón de pliegues y cabalgaduras de la Sierra Madre Oriental desde el norte de Veracruz hasta el sur de Nuevo León. En la localidad de Cerro Boludo (Hidalgo) se colectaron muestras de margas calcáreas provenientes del “Otates Horizon” que incluye un conjunto de foraminíferos planctónicos bien conservados, compuesto por Globigerinelloides algerianus Cushman and ten Dam, 1948, Globigerinelloides ferreolensis (Moullade, 1961), Globigerinelloides barri (Bolli, Loeblich and Tappan, 1957) Globigerinelloides aptiensis Longoria, 1974, Globigerinelloides blowi (Bolli, 1959), Hedbergella roblesae (Obregón de la Parra, 1959), H. occulta Longoria, 1974, H. luterbacheri Longoria, 1974, H. trochoidea Longoria, 1974, H. similis Longoria, 1974, Pseudoplanomalina cheniourensis (Sigal, 1952) and Schackoina cenomana (Schacko, 1897). Los radiolarios también están presentes.
Con base en el conjunto de foraminíferos planctónicos fue reconocida la Zona de Rango Total Globigerinelloides algerianus de la parte temprana a media del Aptiano tardío. La reconstrucción paleoambiental deducida de la litología y de la asociación de foraminíferos sugiere un depósito pelágico abierto; además la presencia de framboides de pirita y materia orgánica indican condiciones de disminución de oxígeno en condiciones meso a eutróficas vinculadas probablemente al “evento anóxico del Aptiano tardío”.
ANALYSIS OF FACTORS AFFECTING PROFIT MANAGEMENT IN PROPERTY COMPANIES
Authors: Renofa Simanjuntak Desi , Nelsari Malau Yois , Kencana Wari Yuni 
Published: April 2022

This study aims to determine the effect of Financei Leverage, Return on Assets, Net Profit Margin, Company Size on Management in Property Companies listed on Bursa Efek Indonesia 2017-2019. The data used is sourced from annual data via the www.idx.co.id website, which has been selected based on predetermined criteria. The population used in this company is all property companies, totaling 15 companies, using a purposive sample of 45 samples. This research is expected to become a science that can help further researchers and can also help students or the general public who need information from this research. From this research, it can be seen that Finance Leverage and partially old management have no influence on Return.On in Property Companies, while Net Profit Margin and Company Size partially affect Profit Management in Property Companies
A abordagem dos três momentos pedagógicos: aplicação no estudo de funções orgânicas e meio ambiente
Authors: Diniz Francisco Espedito , Da Silva Clécio Danilo Dias , Bizerra Ayla Márcia Cordeiro , Dos Santos Daniele Bezerra 
Published: April 2022

O trabalho objetivou analisar as contribuições de uma Sequência Didática (SD) fundamentada nos três momentos pedagógicos (TMP), no processo de ensino-aprendizagem de estudantes do Ensino Médio sobre os conteúdos de funções orgânicas e suas relações com o meio ambiente. A pesquisa demonstrou que a aplicação da SD facilitou o processo de construção do conhecimento dos alunos sobre os conteúdos químicos, contextualizando-os com um problema socioambiental. Pode-se inferir que a SD fundamentada nos TMP pode ser utilizada por professores dentro da disciplina de química, visto que ela é de fácil aplicação e apresenta flexibilidade para adaptação a realidades, conteúdos e públicos diversos.
OS DILEMAS E OS DESAFIOS NA FORMAÇÃO DOCENTE
Authors: Barreto Denise Brito , Guedes Neide Cavalcante 
Published: April 2022

Este artigo apresenta considerações de uma pesquisa que teve como problemática central analisar os dilemas e os desafios na formação docente e no desenvolvimento das aulas neste cenário atual. Sendo assim, este estudo conduziu-se por meio de uma pesquisa qualitativa com três (3) professoras de escolas públicas do ensino básico, na cidade de Vitória da Conquista, no estado da Bahia. Por seu caráter exploratório, a pesquisa qualitativa provocou, nas entrevistadas, reflexão sobre o tema abordado, apontando aspectos subjetivos que constituem o seu fazer pedagógico. Priorizamos a abordagem qualitativa por ser a que melhor oferece condições de explorar a temática aqui scocializada e por atribuir, à nossa pesquisa investigação, o aspecto descritivo. Nos diálogos realizados, nesse contexto, os acontecimentos e as relações sociais foram analisadas pelas docentes para melhor exporem os seus pensamentos e as suas ações sobre dilemas e desafios na formação docente.
PROMOVER O DESENVOLVIMENTO DO PENSAMENTO CIENTÍFICO QUÍMICO BASEADO EM MODELOS DIDÁTICOS COMO MEDIADORES NA APRENDIZAGEM DO EQUILÍBRIO QUÍMICO
Authors: Duran Alexandra Castaño , Garay Fredy Ramon Garay 
Published: April 2022

A análise dos conhecimentos profissionais, práticos e básicos que um professor deve utilizar para projetar, validar e executar uma estratégia didática, com o objetivo de ensinar um conceito químico que estrutura o corpus conceitual da química, levou a propor a modelagem como estratégia de ensino da "Mudança Química", tendo como objetivo a aprendizagem dos alunos do décimo ano, baseando a estruturação da proposta nas formulações teóricas da didática da química. A estratégia de intervenção foi concebida e validada com base na modelagem científico-escolar, o que permitiu determinar e comparar as interpretações dos alunos do décimo ano sobre o modelo científico de mudança química. Os estudantes tiveram que analisar vários fenômenos cotidianos, priorizando, dentro da estratégia, as habilidades de trabalho colaborativo, criatividade, observação, indagação e argumentação. Os resultados mostram que as dificuldades dos estudantes estavam relacionadas a interpretações microscópicas da matéria. Os recursos didáticos utilizados pelo professor mostram erros conceituais em relação às teorias e conceitos anteriores e fundamentais para a compreensão do conceito. Conclui-se que a didática da química deve ser reforçada, a pesquisa sobre educação em química deve ser realizada e as estratégias de ensino para esta ciência devem ser repensadas.
Higher Mortality Rates Associated with Clostridioides difficile Infection in Hospitalized Children with Cystic Fibrosis
Authors: Santhanam Prathipa , Egberg Matthew , Kappelman Michael D. 
Published: April 2022

Objective(s): To determine the impact of Clostridioides
difficile Infection (CDI) among pediatric Cystic Fibrosis (CF)
hospitalizations using a large nationally representative pediatric
hospital database .Study design: We identified Cystic
Fibrosis-related hospitalizations during the years 1997 to 2016 in the
Kids’ Inpatient Database [KID] and compared in-hospital mortality,
Length of Stay [LOS], and hospital charges among hospitalizations
with and without a coexisting diagnosis of C. difficile using
logistic regression models for mortality and general linear models with
gamma distribution and logarithmic transformation for LOS and hospital
charges. We also evaluated temporal trends in the proportion of CF
hospitalizations with concomitant CDI using data published triennially
Results: We analyzed 21, 616 pediatric CF hospitalizations
between the years 1997 to 2016 and found a total of 240 (1.1%)
hospitalizations with concurrent CDI diagnosis. Adjusted analyses
demonstrated an association of CDI with increased mortality (OR 5.2,
95% 95% CI 2.5-10.7), longer LOS (46.5% increment, 95% CI
36.0-57.1), and higher charges (65.8% increment, 95% CI 53.5-78.1) for
all comparisons. The proportion of CF hospitalizations with CDI
increased over time from 0.64% in 1997 to 1.73% in 2016
(p<0.001). Conclusion(s): As CDI is associated with
excess mortality, LOS, and cost in children hospitalized for CF, efforts
to reduce infection rates and aggressive diagnosis and treatment of
active infections should be prioritized to improve hospital outcomes
among children with CF.
Trends and Demographic Disparities in Diabetes Hospital Admissions: Analyses of Serial Cross-Sectional National and State Data, 2008–2017
Authors: Turbow Sara D. , Uppal Tegveer S. , Haw J. Sonya , Chehal Puneet , Fernandes Gail , Shah Megha , Rajpathak Swapnil , Ali Mohammed K. , Narayan K.M. Venkat 
Published: April 2022

OBJECTIVE
To analyze national and state-specific trends in diabetes-related hospital admissions and determine whether disparities in rates of admission exist between demographic groups and geographically dispersed states.

RESEARCH DESIGN AND METHODS
We conducted serial cross-sectional analyses of the National Inpatient Sample (2008, 2011, 2014, and 2016) and State Inpatient Databases for Arizona, Florida, Kentucky, Iowa, Maryland, Nebraska, New Jersey, New York, North Carolina, Utah, and Vermont for 2008, 2011, 2014, and 2016/2017 among adult patients with type 1 and type 2 diabetes–related ICD codes (ICD-9 [250.XX] or ICD-10 [E10.XXX, E11.XXX, and E13.XXX]. We measured hospitalization rates for people with diabetes (all-cause hospitalizations) and for admissions with a primary diagnosis of diabetes or diabetes-related complications (diabetes-specific hospitalizations) per 10,000 people per year.

RESULTS
Nationally, all-cause and diabetes-specific hospitalizations declined by 3.1% (95% CI −5.5, −0.7) and 19.1% (95% CI −21.6, −16.6), respectively, over 2008 to 2016. The analysis of individual states showed that diabetes-specific admissions in individuals ≥65 years old declined during this time (16.3–48.8% decrease) but increased among patients 18–29 years old (10.5–81.5% increase) and that rural diabetes-specific admissions decreased in just over half of the included states (15.2–69.2% decrease). There were no differences in changes in admission rates among different racial/ethnic groups.

CONCLUSIONS
Overall, rates of diabetes-related hospitalizations decreased over 2008 to 2016/2017, but there were large state-level differences across subgroups of patients. The rise in diabetes hospitalizations among young adults is a cause for concern. These state- and subpopulation-level differences highlight the need for state-level policies and interventions to address disparities in diabetes health care use.
A Critical Discourse Analysis of “Discrimination Starts Before and Lasts Our Entire Lives” Speech by Charlotte Helene Fien: Discrimination Through Termination
Authors: Ayuningtyas Inggita Pramesti , Kusumawardani Maria Regina Anna Hadi 
Published: April 2022

Down syndrome people are often underestimated by society. It is because of their disability to do difficult things and their physical appearances. This common opinion has been broken by Charlotte Helene Fien, a representative of Down Syndrome people at the United Nations. This issue results in a social wrong which is covered by the society’s justification. This social wrong is indirectly depicted in Charlotte’s speech. The aim of this research is to uncover the social wrong that evolves in our society. The method used in this research is four stages by Roy Bhaskar (1986). SFG is utilized in this research to give linguistic evidence in interpreting the speech. The results show that social wrong found in the speech is termination of Down Syndrome babies. It is hard to be found because society is a lack of awareness about life values and it is considered as normal and true. However, this social wrong is still needed in the society because it gives benefits for parents and improves society’s standard of living. In order to stop this social wrong, society has to change their opinion, take real actions, and make policies to protect people with Down Syndrome.Keywords: Down Syndrome, social wrong, Systemic Functional Grammar, Charlotte
PENGARUH MODEL DIRECT INTRUCTION BERBANTUAN MEDIA HAND OUT TERHADAP HASIL BELAJAR DASAR POLA
Authors: Ampera Dina , Naibaho Emma Natalia , . Nurhayati , . Farihah 
Published: April 2022

Abstrak : Penelitian ini bertujuan untuk mengetahui efek dari model direct instruction berbantuan media hand out terhadap hasil belajar pola dasar di kelas X di Sekolah Menengah Kejuruan 1 Stabat. Jenis penelitian adalah quasi-experiment dengan desain Post Test Only Design. Sampel diambil dengan menggunakan total sampling, yaitu kelas X-2 yang berjumlah 35 orang sebagai kelas eksperimen menggunakan model direct instruction berbantuan media hand out dan X-1 yang berjumlah 35 orang sebagai kelas kontrol menggunakan model pembelajaran konvensional berbantuan media hand out. Instrumen yang digunakan dalam penelitian ini adalah lembar observasi yang telah dinyatakan valid oleh validator. Hasil perhitungan pengujian hipotesis dengan uji t diperoleh thitung > ttabel (20,05 > 1,66), yang berarti bahwa hipotesis alternatif (Ha) diterima. Adanya pengaruh positif dan signifikan terhadap hasil pembelajaran pola dasar membuat tubuh bagian atas dengan teknik mengalungkan menggunakan model intrusi langsung dibantu media dengan cara kelas X di Sekolah Menengah Kejuruan 1 Stabat. Kata kunci: Intrusi Langsung, Hand Out, Hasil Belajar Abstract :This researh have purpose to know the effect of direct instruction model aided hand out media toward learning outcomes of basic patterns in class X fashion at vocational high school 1 Stabat in academic. The type of researh is quasi-experiment with design Post Test Only Design. The sampel was take by using total sampling, that is class X-2 which totaled 35 people as experiment class using direct intruction model assisted hand out media and X-1 which totaled 35 people as control class using conventional learning models aided hand outs media. The instrument used in this research is the observation sheet that has been declared valid by the validator. The calculation result of hypothesis testing by t test obtained tcount > ttable (20.05 > 1.66), which means that the alternative hypothesis (Ha) is accepted. the existence of positive and significant influence on the learning result of basic pattern making upper body with a draping technique using direct intruction model aided hand out media in class X fashion at vocational high school 1 Stabat. Keywords: Direct Intruction, Hand Out, Learning Outcomes
Formulasi Sabun Antibakteri Fraksi N-Heksan Daun Karamunting (Rhodomyrtus tomentosa) Terhadap Staphylococcus aureus
Authors: Leny Leny , Noverita Tetty , Simatupang Adelina , Iskandar Benni 
Published: April 2022

Bakteri merupakan uniseluler, pada umumnya tidak berklorofil, dan mempunyai ukuran yang sangat kecil dimana hanya dapat dilihat dengan bantuan mikroskop. Tujuan penelitian untuk mengetahui ekstrak fraksi n-heksan daun karamunting (Rhodomyrtus tomentosa) dengan konsentrasi 2% dapat diformulasikan menjadi sediaan sabun mandi padat yang stabil menurut SNI 06-3532-2016 dan sebagai antibakteri terhadap bakteri Staphylococcus aureus.Penelitian ini merupakan penelitian eksperimental yang dimulai dengan pembuatan ekstrak fraksi n-heksan dari daun karamunting (Rhodomyrtus tomentosa), dilanjutkan dengan memformulasikan ekstrak menjadi bentuk sabun padat yang terbagi atas 3 konsentrasi yaitu 2%, 4%, dan 6%. Sediaan sabun padat kemudian diuji karakteristik fisik sediaan dan aktivitas antibakterinya terhadap Staphylococcus aureus.Hasil penelitian menunjukkan bahwa ekstrak fraksi n-heksan daun karamunting (Rhodomyrtus tomentosa) dapat diformulasikan ke dalam bentuk sabun padat yang stabil menurut SNI 06-3532-2016 dan ekstrak fraksi n-heksan daun karamunting (Rhodomyrtus tomentosa) dengan konsentrasi 2% mempunyai aktivitas sebagai antibakteri terhadap bakteri Staphylococcus aureus dengan hambat sebesar 9,91 mm, konsentrasi 4% sebesar 9,95 mm, dan konsentrasi 6% sebesar 10,6 mm, dimana pada penelitian ini digunakan pembanding dengan kontrol negatif dan pada kontrol positif menggunakan sabun asepso yang mempunyai daya hambat sebesar 18,51 mm.Kesimpulan dalam penelitian ini adalah formula sabun mandi padat dengan penambahan ekstrak fraksi n-heksan sebanyak 2% dapat menghambat pertumbuhan bakteri Staphylococcus aureus dalam kategori sedang, konsentrasi 6% mampu menghambat dalam kategori kuat namun tidak menunjukkan daya hambat yang signifikan antar kelompok F1, F2, dan F3.