bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of CD229 as novel marker in measurable residual disease assessment in multiple myeloma—An evidence‐based approach
Authors: Rai Sandeep , Das Nupur , Gupta Ritu , Kumar Lalit , Sharma Atul , Singh Saroj , Prajapati Vijay K. 
Published: November 2022

AbstractIntroductionCD229 has been found to be a useful plasma cell (PC) gating marker in multiple myeloma (MM). This study analyses the expression profile of CD229 on various bone marrow compartments namely, PC, non‐PC and hematogones (HGs) using Multiparameter flow cytometry (MFC). Furthermore, it evaluates the ability of CD229 to delineate normal PC (NPC) from aberrant PC (APC) in measurable residual disease assessment (MRD) in MM.MethodsBone marrow aspirates from patients diagnosed with MM (per standard IMWG criteria) were collected in EDTA and processed for MFC using a single tube 14‐color antibody panel as per standard operating procedure.ResultsA total of 74 patients with a diagnosis of MM (26 treatment naïve and 48 on therapy) were evaluated. The expression of CD229 was homogenous on both the PC and HG compartments as compared to CD138 and CD38. On comparing the expression of individual markers, it was found to be statistically significant between PC, HGs and non‐PC for all three markers (p < 0.001). APC showed lower median expression of CD38 and higher median expression of CD138 and CD229 as compared to NPC and was found to be statistically significant for all markers (p < 0.001). In terms of differential expression on NPC and APC; CD38 was found to be the most aberrantly expressed (70%; 52/74) followed by CD229 (7%; 5/74) and CD138 (5%; 4/74).ConclusionsCD229 can be used for the identification of PC and due to relatively homogenous expression; it can be used as a suitable marker for targeted therapies. However, precise discrimination of NPC from APC cannot be reliably achieved with CD229, limiting its utility as a useful marker of diagnostic relevance and MRD assessment in MM.
Emergency typhoid immunisation after the fall of Singapore 1942
Authors: Shanks G. Dennis 
Published: November 2022

AbstractSingapore surrendered to the Japanese invasion in February 1942 after its water supply collapsed. At the suggestion of the colonial medical authorities, an emergency typhoid immunisation campaign was then begun using locally manufactured vaccine from extemporary materials; within 3 months, >600 000 had been immunised. Comparison with prewar statistics suggests that a postsurrender typhoid fever epidemic was prevented despite an increase in other enteric infections. Public health crises with disrupted supply chains may make locally manufactured vaccines of increasing importance in the future.
Intersectional organizing: Building solidarity through radical confrontation
Authors: Lee Tamara L. , Tapia Maite 
Published: November 2022

AbstractIR scholars reference intersectionality in relation to organizing, but the field lacks a theoretical construct. Based on 2 years of intimate data access, we examine the 2017 U.S. Women's March as a critical case of “intersectional organizing.” We ground this empirical case study in Critical Race and Intersectionality Theory to show how the intersectional organizing model employed by the Women's March handles identity‐based fragmentation, with lessons for building a more inclusive labor movement.
I can(not) control myself: The role of self‐transcendence values and situational strength in explaining depleted managers' interpersonal injustice
Authors: Behrendt Philine , Camps Jeroen , Klumb Petra L. 
Published: November 2022

AbstractThis study investigated whether, and under what conditions, self‐control demands (SCD) are associated with less interpersonal justice (politeness or respect) and more interpersonal injustice (degrading or inappropriate remarks) behavior. Drawing from extended self‐control theory and integrating the motivation literature, we posit that (1) SCD have a stronger effect on actors' attempts not to be unfair than on their attempts to be fair because avoidance behavior is more demanding than approach behavior. Further, extended self‐control theory posits that people control themselves more effectively when they are personally motivated and external standards are present. Accordingly, we further posit that (2) emphasizing self‐transcendence values (i.e., the stable motivational goal to consider others' welfare) and (3) acting in strong situations (i.e., the presence of external normative standards on appropriate behavior) buffer the SCD effect. Results from two realistic simulation studies show that SCD were related to actors' interpersonal justice and injustice behavior. Across both studies, different results patterns, and relationships with the other variables for justice and injustice emerged. Thus, although the stronger effect of SCD on injustice (vs. justice) was not generally supported, the finding suggests that adhering to and not violating interpersonal justice rules are indeed different from one another. In addition, SCD were less detrimental among actors with higher self‐transcendence values and when actors operated in strong (vs. weak) contexts. A three‐way interaction showed that especially among actors with low self‐transcendence values, who act in weak contexts, SCD provoked injustice. We discuss theoretical and practical implications.
Who owns the land? Territorial ownership understandings and intergroup relations in a settler society
Authors: Nooitgedagt Wybren , Martinović Borja , Verkuyten Maykel , Yogeeswaran Kumar 
Published: November 2022

AbstractConflicts over the ownership of territory have shaped intergroup relations between indigenous and nonindigenous groups in settler societies. Using latent profile analysis, we found four different subgroups of individuals among a sample of European New Zealanders based on their perceived ingroup (NZ European) and outgroup (Māori) ownership. Most people (75.9%) perceived shared territorial ownership, but there were also individuals predominantly recognizing ingroup ownership (8.2%), outgroup ownership (6.4%), or no territorial ownership (9.4%). These subgroups differed in meaningful ways in their support for principles of ownership, perceived rights and responsibilities, compensation for Māori, and support for strict immigration policies.
SNP‐ and haplotype‐based single‐step genomic predictions for body weight, wool, and reproductive traits in North American Rambouillet sheep
Authors: Araujo Andre C. , Carneiro Paulo L. S. , Oliveira Hinayah R. , Lewis Ronald M. , Brito Luiz F. 
Published: November 2022

AbstractRambouillet sheep are commonly raised in extensive grazing systems in the US, mainly for wool and meat production. Genomic evaluations in US sheep breeds, including Rambouillet, are still incipient. Therefore, we aimed to evaluate the feasibility of performing genomic prediction of breeding values for various traits in Rambouillet sheep based on single nucleotide polymorphisms (SNP) or haplotypes (fitted as pseudo‐SNP) under a single‐step GBLUP approach. A total of 28,834 records for birth weight (BWT), 23,306 for postweaning weight (PWT), 5,832 for yearling weight (YWT), 9,880 for yearling fibre diameter (YFD), 11,872 for yearling greasy fleece weight (YGFW), and 15,984 for number of lambs born (NLB) were used in this study. Seven hundred forty‐one individuals were genotyped using a moderate (50 K; n = 677) or high (600 K; n = 64) density SNP panel, in which 32 K SNP in common between the two SNP panels (after genotypic quality control) were used for further analyses. Single‐step genomic predictions using SNP (H‐BLUP) or haplotypes (HAP‐BLUP) from blocks with different linkage disequilibrium (LD) thresholds (0.15, 0.35, 0.50, 0.65, and 0.80) were evaluated. We also considered different blending parameters when constructing the genomic relationship matrix used to predict the genomic‐enhanced estimated breeding values (GEBV), with alpha equal to 0.95 or 0.50. The GEBV were compared to the estimated breeding values (EBV) obtained from traditional pedigree‐based evaluations (A‐BLUP). The mean theoretical accuracy ranged from 0.499 (A‐BLUP for PWT) to 0.795 (HAP‐BLUP using haplotypes from blocks with LD threshold of 0.35 and alpha equal to 0.95 for YFD). The prediction accuracies ranged from 0.143 (A‐BLUP for PWT) to 0.330 (A‐BLUP for YGFW) while the prediction bias ranged from −0.104 (H‐BLUP for PWT) to 0.087 (HAP‐BLUP using haplotypes from blocks with LD threshold of 0.15 and alpha equal to 0.95 for YGFW). The GEBV dispersion ranged from 0.428 (A‐BLUP for PWT) to 1.035 (A‐BLUP for YGFW). Similar results were observed for H‐BLUP or HAP‐BLUP, independently of the LD threshold to create the haplotypes, alpha value, or trait analysed. Using genomic information (fitting individual SNP or haplotypes) provided similar or higher prediction and theoretical accuracies and reduced the dispersion of the GEBV for body weight, wool, and reproductive traits in Rambouillet sheep. However, there were no clear improvements in the prediction bias when compared to pedigree‐based predictions. The next step will be to enlarge the training populations for this breed to increase the benefits of genomic predictions.
Social distancing and trouble sleeping during COVID‐19 pandemic among older adults in Europe: Mediating and moderating effects
Authors: Khalaila Rabia , Shiovitz‐Ezra Sharon 
Published: November 2022

AbstractPurposeWe examined the association between social distancing and trouble sleeping during the COVID‐19 outbreak in adults 65+, and underlying potential mechanisms.MethodsWe used data from the extensive Survey of Health, Aging, and Retirement in Europe (SHARE). Logistic regression analysis tested the direct and indirect associations between social distancing and trouble sleeping during the pandemic, the mediation effect of depression, and the moderating‐mediation effects of perceived economic status and employment status.FindingsSocial distancing was associated with a higher probability of sleeping problems, partially mediated by depression and moderated by employment status and perceived economic status. Depression had a greater effect on trouble sleeping among those unemployed and those who perceived their economic status as difficult or partially difficult.ConclusionCOVID‐19 policy of lockdowns and physical distancing has negative consequences on sleeping and the development of depressive symptoms among older adults.Clinical and policy relevanceClinicians should be aware of sleep problems in older adults during the pandemic and after, and try to reduce depressive symptoms. Policymakers should determine future policies and regulations that encourage employment among older adults and improve their economic resilience during pandemics.
Impulsivity in patients with acne excoriee
Authors: Öğüt Çağrı , Öğüt Neslihan Demirel 
Published: November 2022

AbstractBackgroundImpulsivity is the tendency to make decisions and act quickly without adequate planning and anticipating risks. Impulsivity is among the core symptoms of many psychiatric disorders. In addition, impulsivity can affect the course of various diseases shaped by behaviors.AimsThis study aimed to evaluate the relationship between the presence of acne excoriee and different impulsivity dimensions.Study DesignA case–control study.MethodsThirty patients with acne excoriee (AE+) and 30 acne vulgaris patients without excoriated lesions (AE‐) enrolled in this study. Impulsivity was evaluated by The Barratt Impulsivity Scale (BIS). In addition, The Beck Anxiety Inventory, The Beck Depression Inventory, and The Skin Picking Scale were applied to assess the clinical characteristics of the participants.ResultsAE+ patients had higher non‐planning subscale scores of BIS than AE‐ patients in this study. In addition, the acne‐picking severity score determined by The Skin Picking Scale was positively correlated with non‐planning subscale scores of BIS. There was no significant difference between the groups regarding the Beck Depression Inventory and Beck Anxiety Inventory.ConclusionsThese results indicate that AE patients have a lack of forethought. In other words, it has been shown that impulsive personality traits, which indicate a lack of planning for the future, may be associated with the acne‐picking behavior of the patients.
Perceived employability and employee strain: A meta‐analysis
Authors: Harari Michael B. , McCombs Kate M. , Thams Yannick 
Published: November 2022

AbstractThis meta‐analysis addresses the association between perceived employability (PE) and employee strain (k = 34). Consistent with expectations, PE was negatively related to strain (ρ = −.12, 95% CI = −.16 to −.08). Moderator analysis showed that this relationship was stronger post‐2008 (ρ = −.20, 84% CI = −.23 to −.17) versus pre‐2008 (ρ = −.06, 84% CI = −.08 to −.05) and in high (ρ = −.17, 84% CI = −.21 to −.14) versus low (ρ = −.07, 84% CI = −.09 to −.06) uncertainty avoidant cultures. Our results suggest that career competency development interventions can be effective for reducing employee strain and that national uncertainty avoidance need be incorporated into models of boundaryless careers, especially as it relates to employee health and well‐being.
Perceptions of School Climate Shape Adolescent Health Behavior: A Longitudinal Multischool Study
Authors: Ko Michelle Y. , Rosenberg Sofia M. , Meza Benjamin P. L. , Dudovitz Rebecca N. , Dosanjh Kulwant K. , Wong Mitchell D. 
Published: November 2022

ABSTRACTBackgroundAdolescent behaviors and academic outcomes are thought to be shaped by school climate. We sought to identify longitudinal associations between school climate measures and downstream health and academic outcomes.MethodsData from a longitudinal survey of public high school students in Los Angeles were analyzed. Eleventh‐grade health and academic outcomes (dependent variables, eg, substance use, delinquency, risky sex, bullying, standardized exams, college matriculation), were modeled as a function of 10th‐grade school climate measures (independent variables: institutional environment, student‐teacher relationships, disciplinary style), controlling for baseline outcome measures and student/parental covariates.ResultsThe 1114 student respondents (87.8% retention), were 46% male, 90% Latinx, 87% born in the United States, and 40% native English speakers. Greater school order and teacher respect for students were associated with lower odds of multiple high risk behaviors including 30‐day alcohol use (odds ratio [OR] 0.81; 95% confidence interval [CI] [0.72, 0.92] and OR 0.73; [0.62, 0.85]) and 30‐day cannabis use (OR 0.74; [0.59, 0.91] and OR 0.76; [0.63, 0.92]). Neglectful disciplinary style was associated with multiple poor health and academic outcomes while permissive disciplinary style was associated with favorable academic outcomes.Implications for School Health Policy, Practice, and EquitySchool health practitioners may prospectively leverage school environment, teacher‐student relationships, and disciplinary style to promote health and learning.ConclusionsOur findings identify specific modifiable aspects of the school environment with critical implications for life course health.
Leveraging Comprehensive Sexuality Education as a Tool for Knowledge, Equity, and Inclusion
Authors: Woolweaver Ashley B. , Drescher Anne , Medina Courtney , Espelage Dorothy L. 
Published: November 2022

AbstractBACKGROUNDSexual education programs in the United States are rooted in inequitable structures and are often inadequate at educating marginalized student groups such as students of color, Lesbian, Gay, Bisexual, Transgender, Queer (LGBTQ+), women, and disabled students.CONTRIBUTIONS TO THEORYCurrent sexual education is irregularly implemented and often excludes or misrepresents the experiences of students with marginalized identities. This theoretical paper specifically discusses ways that sexual education has been harmful or exclusionary for marginalized student groups and how a shift toward making sexual education inclusive and equitable will improve outcomes for students of all identities.IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITYThis paper discusses several recommendations on improving access to equitable sexual health education for all students including reviewing and improving sexual education curriculum and delivery, as well as the need for additional research focused on this topic.CONCLUSIONSThis article provides an overview on the current sexual education system, its inadequacies, and how comprehensive sexuality education programs can be leveraged as a tool for equity for students of all backgrounds, but particularly those who are underrepresented in sexual education curricula.
Toward quantification of loop diuretic responsiveness for congestive heart failure
Authors: Oyama Mark A. , Adin Darcy 
Published: November 2022

AbstractDiuretics, such as furosemide, are routinely administered to dogs with congestive heart failure (CHF). Traditionally, dose and determination of efficacy primarily are based on clinical signs rather than quantitative measures of drug action. Treatment of human CHF patients increasingly is guided by quantification of urine sodium concentration (uNa) and urine volume after diuretic administration. Use of these and other measures of diuretic responsiveness is associated with decreased duration of hospitalization, complication rates, future rehospitalization, and mortality. At their core, loop diuretics act through natriuresis, and attention to body sodium (Na) stores and handling offers insight into the pathophysiology of CHF and pharmacology of diuretics beyond what is achievable from clinical signs alone. Human patients with low diuretic responsiveness or diuretic resistance are at risk for difficult or incomplete decongestion that requires diuretic intensification or other remedial strategies. Identification of the specific etiology of resistance in a patient can help tailor personalized interventions. In this review, we advance the concept of loop diuretic responsiveness by highlighting Na and natriuresis. Specifically, we review body water homeostasis and congestion in light of the increasingly recognized role of interstitial Na, propose definitions for diuretic responsiveness and resistance in veterinary subjects, review relevant findings of recent studies, explain how the particular cause of resistance can guide treatment, and identify current knowledge gaps. We believe that a quantitative approach to loop diuretic usage primarily involving natriuresis will advance our understanding and care of dogs with CHF.
Contrasting effects of vegetation cover and site condition on biocrust communities in subhumid drylands
Authors: Mallen‐Cooper Max , Ding Jingyi , Eldridge David J. 
Published: November 2022

AbstractQuestionsBiocrusts perform critical functional roles in drylands, where they are regulated predominantly by differences in climate and soils. We asked whether biocrust cover and composition differ among sites of varying vegetation cover and condition.LocationSubhumid drylands in the Namoi Region, eastern Australia.MethodsWe assessed the effects of different vegetation strata (trees, shrubs, groundcover) and site vegetation condition (index of quality based on vascular plant richness, and the proportion of perennial and native vascular plants) on the cover, richness and composition of biocrust communities at 43 sites in semi‐arid eastern Australia.ResultsWoody plant cover at our sites was negatively related to biocrust cover and richness, but there was only a weak relationship between groundstorey plant cover and biocrusts, suggesting that woody plants are not facilitating biocrusts in this environment. Conversely, greater site condition was strongly associated with richer and more extensive biocrust communities, likely driven by a common response to livestock grazing intensity. There was also a significant multivariate association between biocrust composition and vegetation condition. For example, sites of poorer condition were occupied by generalist taxa, typically short mosses and squamulose lichens, while sites in better condition were characterised by a richer assemblage that included foliose and fruticose lichens, and taller, disturbance‐sensitive mosses.ConclusionsOur study provides empirical evidence of the negative relationship between woody plant cover and biocrusts (amensalism), and the filtering effect of vegetation condition on different biocrust taxa. Predicted drier climates could enhance biocrust dominance by suppressing woody plant growth, while intensified land‐use disturbances are likely to filter biocrust specialists such as fruticose and foliose lichens that are associated with sites in better condition.
Comprehensible to Whom? Examining Rater, Speaker, and Interlocutor Perspectives on Comprehensibility in an Interactive Context
Authors: NAGLE CHARLIE L. , TROFIMOVICH PAVEL , GRANTHAM O'BRIEN MARY , KENNEDY SARA 
Published: November 2022

AbstractComprehensibility has emerged as a useful and intuitive means of globally evaluating second language (L2) speakers in many research and instructional contexts. In most cases, L2 speakers’ comprehensibility is assessed by external listeners who do not engage in extensive communication with the speakers, even though the degree to which a speaker is comprehensible is presumably of greatest concern to their interlocutor. If comprehensibility is defined as the ease with which speakers come to understand one another, then interaction‐based assessments, which would include self and peer ratings, might provide different insight into interactive comprehensibility compared to assessments by external listeners. To examine this issue, in this study, 20 pairs of L2 English interactants rated themselves and their partner on 7 occasions distributed throughout a 17‐minute interaction encompassing 3 communicative tasks, and recordings of the interaction were subsequently presented to external raters for evaluation. Mixed‐effects models were used to compare the shape of the comprehensibility curves over time and the self, partner, and rater scores at each rating episode. Results demonstrated that self and partner assessments were always aligned, but raters consistently assigned significantly lower comprehensibility scores to the interactants. These findings have implications for how comprehensibility, and indeed other listener‐based constructs, are assessed.