bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of spdC gene expression on virulence and antibiotic resistance in clinical Staphylococcus aureus isolates
Authors: Bakr Mayada E. , Kashef Mona T. , Hosny Alaa El-Dien M. S. , Ramadan Mohammed A. 
Published: May 2022

Abstract
Surface protein display C (SpdC) protein was described as a novel virulence factor of Staphylococcus aureus that affects biofilm formation and pathogenesis and favors resistance to antimicrobials targeting cell wall. We evaluated the possible correlation between spdC gene expression level and virulence as well as antibiotic resistance phenotypes in S. aureus clinical isolates. The antimicrobial susceptibility of S. aureus clinical isolates (n = 100) was determined by the disk diffusion method. Vancomycin susceptibility was determined by the broth microdilution method. The level of the extracellular proteases and delta-hemolysin was evaluated by measuring the proteolysis and hemolysis zone diameters in skim milk and blood agar plates, respectively. Biofilm formation was assayed using the 96-well microtiter plate method. Most of the isolates (81%) were multidrug-resistant and about half of the isolates (49%) were methicillin-resistant S. aureus. Hemolysin, protease, and biofilm production were detectable in 79%, 71%, and 96% of the isolates. No significant correlation was detectable between the level of spdC gene expression and the activity of tested virulence factors or the antimicrobial resistance phenotype. Therefore, the role of SpdC protein as a virulence regulator in S. aureus needs further evaluation together with the determination of the predominant regulators for each virulence factor.
Potential effects of heavy metal pollution from a cement factory near Saudi Arabia’s largest green turtle rookery
Authors: Tanabe Lyndsey K. , Carvalho Susana , Dasari Vijayalaxmi , Nasif Areen , O’Toole Kaitlyn A. , Berumen Michael L. 
Published: May 2022

AbstractSand samples were collected from four beaches near a cement factory in Ras Baridi, north of Yanbu, which hosts the largest green turtle rookery in Saudi Arabia. Heavy metal concentrations (Cd, Pb, Fe, Cr, Ni, Se, Sb, As, and Cu) were measured at three different depths. For most elements, there were no significant differences in concentrations among depths; however, significant differences were found among the nesting beaches in Ras Baridi, which were likely influenced by the wind direction from the factory. Fe, Cr, Cu, and Ni had elevated contamination factor values, suggesting that the nesting beaches downwind and adjacent to the cement factory contained moderately contaminated sand. Given the possibility of heavy metals being absorbed through eggshells, there is a potential risk of heavy metal contamination in clutches laid in Ras Baridi. The rising threat to the local ecology in Saudi Arabia due to recent coastal developments for tourism projects highlights the importance of monitoring heavy metal concentrations over time.
Mapping and Making Meaning from Undergraduate Student Engagement in High-Impact Educational Practices
Authors: Trogden Bridget G. , Kennedy Cazembe , Biyani Nathan K. 
Published: May 2022

AbstractInstitutions of higher education often have multiple entry points for first-time and transfer college students to engage in high-impact educational practices (HIPs), well documented to advance student learning outcomes. Some students may seek out repeated opportunities while others engage very little or not at all in activities such as student-faculty research, study abroad, internships, first-year cohort programs, service-learning, and the like. When institutions maintain decentralized data and records on students’ participation, obtaining a true understanding of the "who, what, when, and where" of HIPs can be difficult. In this paper, we present an institutional strategy for longitudinal collection of data for nearly 5,000 entering students across six years and nine different categories of HIPs, and we discuss the opportunities and implications of performing such a study. Additionally, we provide examples of how disaggregation of student data is crucial for using the results to improve curriculum and resource alignment for institutional research and institutional change purposes, supporting the goal of inclusive and equitable college engagement portfolios for all students.
Removal of lindane using electrokinetic soil flushing coupled with air stripping
Authors: de Melo Henrique João Miller , Isidro Julia , Saez Cristina , Dos Santos Elisama V. , Rodrigo Manuel A. 
Published: May 2022

Abstract
This paper evaluates the remediation of soil spiked with lindane using a combined treatment consisting of electrokinetic soil flushing (EKSF) with air stripping to elucidate the main processes occurring in the soil when electric fields of 0.75 V cm−1 and 1.50 V cm−1 are applied. The results demonstrate that lindane is efficiently transported to the anodic and cathodic wells using flushing fluids containing sodium dodecyl sulfate (SDS). Additionally, an important amount is volatilized and stripped with the injected air. In the cathodic well, lindane is rapidly transformed into other species because of the strongly alkaline media. These other species are also found in the portions of soil next to this well, confirming the efficient transport of chlorinated organics with SDS. After 14 days of operation, nearly 50% of the spiked lindane can be removed from the soil. Operation with large electric fields does not improve the performance of the treatment technology and results in lower current intensities and electro-osmotic fluxes and in higher evaporated water, despite the water content in the soil matrix, indicating the coexistence of multiple inputs in these processes.
Graphical abstract
Innovating teaching and instruction in turbulent times: The dynamics of principals’ exploration and exploitation activities
Authors: Pietsch Marcus , Tulowitzki Pierre , Cramer Colin 
Published: May 2022

AbstractIn turbulent environments, schools have to adapt to constantly changing conditions. According to ambidexterity theory, whether they are successful in this primarily depends on their leaders and how they manage the tension between the use of current knowledge (exploitation) and the search for new knowledge (exploration). Through unique top-down and bottom-up pathways, they thus influence the innovation outcome of a school. However, it is so far unclear whether these assumptions are correct. Using data from a panel of principals who are representative of Germany and were surveyed before and during the COVID-19 pandemic, we therefore investigate if and how school leaders adapted to the turbulent environment caused by the pandemic and evaluate the extent to which this had an impact on their schools’ innovations in teaching and instruction. The results demonstrate that principals’ exploration activities increased markedly during the pandemic, while their exploitation activities decreased noticeably. Further, a focus on the use and refinement of existing knowledge in comparatively predictable (pre-COVID-19) environments harmed principals’ readiness to explore new knowledge in increasingly uncertain environments. Nevertheless, exploitation had positive consequences for the innovativeness of schools, and exploration goes along with more radical innovations in teaching and instruction. Our research suggests that schools that innovatively addressed the COVID-19 pandemic had school leaders who were able to quickly shift between the two modes of exploitation and exploration. A capacity to transition seamlessly between these modes of thinking and working thus appears to be vital for the longevity of schools.
Individual Differences in Conversational Self-Touch Frequency Correlate with State Anxiety
Authors: Pang Hio Tong , Canarslan Feride , Chu Mingyuan 
Published: May 2022

AbstractSelf-touches are frequently performed in everyday conversations. Although self-touch appears to relate to itching skin sensations or grooming needs, there has been cumulating evidence that the production of self-touch is associated with emotional regulation and cognitive control. Yet, individuals vary greatly in how often they perform self-touch in conversations. The present study investigated how individuals’ anxiety levels (i.e., state and trait anxiety), personality traits (i.e., neuroticism, agreeableness, extraversion, conscientiousness, and openness), and inhibition ability can contribute to the individual differences in conversational self-touch frequency. Spontaneous self-touch was elicited from a hundred and twenty-seven participants in an animated cartoon description task and a social dilemma-solving task. Results from the correlational analysis showed that the self-touch frequency was significantly positively related to individuals’ state and trait anxiety levels and their neuroticism scores but was significantly negatively related to their agreeableness scores. However, when all predictor variables were entered simultaneously into a multiple regression analysis, the result showed that the state anxiety score was the only significant predictor of the conversational self-touch frequency. This result is consistent with the proposal that self-touch behaviors are produced to regulate negative emotional states such as anxiety and stress. The findings of the present study shed new light on the function of self-touch behaviors in conversations, and highlight the importance of using a broad correlational approach with simultaneous consideration of multiple predictors in future research aiming to understand individual differences in self-touch behaviors.
On a Generalized Central Limit Theorem and Large Deviations for Homogeneous Open Quantum Walks
Authors: Carbone Raffaella , Girotti Federico , Melchor Hernandez Anderson 
Published: May 2022

AbstractWe consider homogeneous open quantum walks on a lattice with finite dimensional local Hilbert space and we study in particular the position process of the quantum trajectories of the walk. We prove that the properly rescaled position process asymptotically approaches a mixture of Gaussian measures. We can generalize the existing central limit type results and give more explicit expressions for the involved asymptotic quantities, dropping any additional condition on the walk. We use deformation and spectral techniques, together with reducibility properties of the local channel associated with the open quantum walk. Further, we can provide a large deviation principle in the case of a fast recurrent local channel and at least lower and upper bounds in the general case.
Antimicrobial peptides: features, applications and the potential use against covid-19
Authors: Mabrouk Dalia Mamdouh 
Published: May 2022

Abstract
Background
Antimicrobial peptides (AMPs) are a diverse class of molecules that represent a vital part of innate immunity. AMPs are evolutionarily conserved molecules that exhibit structural and functional diversity. They provide a possible solution to the antibiotic-resistance crisis.

Main text
These small cationic peptides can target bacteria, fungi, and viruses, as well as cancer cells. Their unique action mechanisms, rare antibiotic-resistant variants, broad-spectrum activity, low toxicity, and high specificity encourage pharmaceutical industries to conduct clinical trials to develop them as therapeutic drugs. The rapid development of computer-assisted strategies accelerated the identification of AMPs. The Antimicrobial Peptide Database (APD) so far contains 3324 AMPs from different sources. In addition to their applications in different fields, some AMPs demonstrated the potential to combat COVID-19, and hinder viral infectivity in diverse ways.

Conclusions
This review provides a brief history of AMPs and their features, including classification, evolution, sources and mechanisms of action, biosynthesis pathway, and identification techniques. Furthermore, their different applications, challenges to clinical applications, and their potential use against COVID-19 are presented.
One-dimensional pattern generation by cellular automata
Authors: Kutrib Martin , Malcher Andreas 
Published: May 2022

AbstractTo determine the computational capacity of cellular automata they are often investigated towards their ability to accept formal languages within certain time constraints. In this paper, we take up an opposite position and look at cellular automata towards their ability to generate patterns, within certain time constraints. As an example we describe a construction of a cellular automaton that generates prefixes of the Oldenburger–Kolakoski sequence within real time. Furthermore, we study the real-time generation of unary and non-unary patterns in depth. In the unary case, we obtain a characterization by time-constructible functions and their corresponding unary formal languages. In the non-unary case, we provide constructions that generate any arbitrary given properly thin context-free language as well as all prefixes of any given automatic sequence.
Acceptability of Overdose Prevention Sites in the Business Community in Baltimore, Maryland
Authors: Sherman Susan G. , Rouhani Saba , White Rebecca Hamilton , Weicker Noelle , Morris Miles , Schneider Kristin , Park Ju Nyeong , Barry Colleen 
Published: May 2022

Abstract
Intervetions are urgently needed to reduce the trajectory of the US opioid overdose epidemic, yet implementation is often hampered by resistance or opposition from key community stakeholders. While businesses are economically and physically impacted by the opioid epidemic, they are rarely engaged in efforts to reduce its impact. The establishment of overdose prevention sites (OPS) is being discussed throughout many US jurisdictions with limited attention to the potential positive role of businesses in that process. We surveyed business owners and employees of businesses located in neighborhoods with concentrated drug markets. The study’s primary aim was to examine their attitudes to locally-placed OPS. An iterative, two-phase sampling strategy was used to identify recruitment zones. In person (December 2019–March 2020) and telephone-based (April–July 2020) surveys were administered to distinct business owners and employees (N = 149). Sixty-five percent of participants supported OPS in their neighborhood and 47% had recently witnessed an overdose in or around their workplace. While 70% had heard of naloxone, and 38% reported having it on the premises. Correlates of supporting an OPS locally included living in the same neighborhood as work (adjusted odds ratio (aOR) 1.99, 95% confidence intervals (CI): 1.30–3.05); having a more positive attitude towards people who use drugs (aOR 1.33, 95% CI: 1.13–1.58); and having recently seen an overdose in/around the workplace (aOR 2.86, 95% CI: 1.11–7.32). Lack of support being an owner (aOR 0.35, 95% CI: 0.15–0.83). These data indicate the extent to which businesses are directly impacted by the opioid epidemic and the power of personal experience in shaping OPS support in advocacy efforts.
Revisiting the Internationalization-Performance Relationship: A Twenty-Year Meta-Analysis of Emerging Market Multinationals
Authors: Wu Sihong , Fan Di , Chen Liang 
Published: May 2022

AbstractWith the rapid growth of emerging market multinational enterprises (EMNEs), increasing interest has been focused on exploring the internationalization-performance (I-P) relationship of EMNEs. Yet findings on the relationship remain contradictory. Although researchers emphasize the home-country-bounded nature of EMNEs, less is known about how home-government features and the EMNEs’ political mindset affect their internationalization and performance. This study integrates and extends the literature on the I-P relationship of EMNEs using a meta-analysis covering a dataset of 218 effect sizes from 186 retrieved studies published between 1998 and 2021. Findings show that the I-P relationship is overall positive, yet it varies across diverse research designs and emerging markets and regions. Also, our findings indicate that home-country government quality and transformability exert significant positive impacts on the relationship, while nationalism negatively moderates the government’s impacts on the relationship. This study pushes the boundaries of EMNE literature through conceptualizing home-government features and incorporating consideration of nationalism in this research field.
A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System
Authors: Bell Kara , Bordenstein Seth R. 
Published: May 2022

AbstractSpecies are fundamental units of biology that exemplify lineage diversification, while symbiosis of microbes and macrobial hosts exemplify lineage unification between the domains of life. While these conceptual differences between speciation and symbiosis often dominate the narrative of the respective fields, Lynn Margulis argued for interconnection between these two subdisciplines of biology in a manner that left a legacy for scholars and students alike to pursue, detail, and discover. The Margulian perspective has always been that host evolutionary processes such as speciation are more impacted by microbial symbioses than typically appreciated. In this article, we present and review the case system that she long envisioned, one in which layers of microbial symbiosis reduce species interbreeding and assist species diversification among a closely related group of small, metallic green, parasitoid wasps from the genus Nasonia.
MoNA: A Forensic Analysis Platform for Mobile Communication
Authors: Spranger Michael , Xi Jian , Jaeckel Lukas , Felser Jenny , Labudde Dirk 
Published: May 2022

AbstractMobile communication devices are a popular means of planning, commissioning and carrying out criminal offenses. In particular, data from messengers such as WhatsApp or Telegram often contain conclusive information. Organized crime also usually involves many devices, but not all of them contain the full history of communication. Rather, it is heavily fragmented due to individual deletions of messages or different joining times to groups. A singular evaluation of individual devices is therefore often not expedient, since important relationships cannot be recognized. Furthermore, communication is often distributed across different channels and modalities and can only be fully and correctly understood through a joint semantic analysis. The linking of related communications of different devices enables an almost complete reconstruction of the communication with a simultaneous reduction in reading effort by merging identical messages. Grouping coherent messages into conversations enables efficient comparison with a knowledge model. Building such a model is complex, but can be supported by a term recommender system. In this paper, MoNA is presented as a platform that implements these approaches and enables an assisted analysis of mobile communications.
Smoke pollution must be part of the savanna fire management equation: A case study from Darwin, Australia
Authors: Jones Penelope J. , Furlaud James M. , Williamson Grant J. , Johnston Fay H. , Bowman David M. J. S. 
Published: May 2022

AbstractSavanna fire management is a topic of global debate, with early dry season burning promoted as a large-scale emissions reduction opportunity. To date, discussions have centred on carbon abatement efficacy, biodiversity and cultural benefits and/or risks. Here we use a case study of Darwin, Australia to highlight smoke pollution as another critical consideration. Smoke pollution from savanna fires is a major public health issue, yet absent so far from discussions of program design. Here, we assess the likely impacts of increased early dry season burning on smoke pollution in Darwin between 2004 and 2019, spanning the introduction and expansion of carbon abatement programs. We found increased smoke pollution in the early dry season but little change in the late dry season, contributing to a net annual increase in air quality standard exceedances. Geospatial analysis suggests this relates to increased burning in the path of early dry season trade winds. This study highlights the complex health trade-offs involved with any large-scale prescribed burning, including for carbon abatement.
Trusting social robots
Authors: Sweeney Paula 
Published: May 2022

AbstractIn this paper, I argue that we need a more robust account of our ability and willingness to trust social robots. I motivate my argument by demonstrating that existing accounts of trust and of trusting social robots are inadequate. I identify that it is the feature of a façade or deception inherent in our engagement with social robots that both facilitates, and is in danger of undermining, trust. Finally, I utilise the fictional dualism model of social robots to clarify that trust in social robots, unlike trust in humans, must rely on an independent judgement of product reliability.
First Glimpse of Gut Microbiota of Quarantine Insects in China
Authors: Yu Yanxue , Wang Qi , Zhou Ping , Lv Na , Li Wei , Zhao Fangqing , Zhu Shuifang , Liu Di 
Published: May 2022

Abstract
Quarantine insects are economically important pests that frequently invade new habitats. A rapid and accurate monitoring method to trace the geographical sources of invaders is required for their prevention, detection, and eradication. Current methods based on genetics are typically time-consuming. Here, we developed a novel tracing method based on insect gut microbiota. The source location of the insect gut microbiota can be used to rapidly determine the geographical origin of the insect. We analyzed 179 gut microbiota samples from 591 individuals of 22 quarantine insect species collected from 36 regions in China. The gut microbiota of these insects primarily included Actinobacteria, Bacteroidetes, Cyanobacteria, Firmicutes, Proteobacteria, and Tenericutes. The diversity of the insect gut microbiota was closely associated with geographical and environmental factors. Different insect species could be distinguished based on the composition of gut microbiota at the phylum level. Populations of individual insect species from different regions could be distinguished based on the composition of gut microbiota at the phylum, class, and order levels. A method for determining the geographical origins of invasive insect species has been established; however, its practical application requires further investigations before implementation.