bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and immunophenotype of abnormal lymphoblast populations at diagnosis of chronic myeloid leukaemia in chronic phase
Authors: Barge Luani , Cleary Rebecca , Morris Kirk , Simleit Erin 
Published: March 2022

AbstractChronic myeloid leukaemia most commonly presents in chronic phase (CML-CP) and it is characterised by granulocytic proliferation. Many patients have an excellent response to tyrosine kinase inhibitor therapy; however, a small proportion will develop lymphoid or myeloid blast crisis, with inferior clinical outcomes. Detection of lymphoblasts at diagnosis of CML-CP has been reported in small case series with conflicting results on the risk of subsequent blast crisis. The aim of this study was to identify the incidence and immunophenotype of abnormal lymphoblast populations in CML-CP. Retrospective review of bone marrow flow cytometry results of consecutive patients with newly diagnosed CML-CP between June 2012 and February 2021 was performed. Lymphoblasts, myeloblasts, haematogones, and mature lymphocytes were evaluated. Fifty-nine patients had bone marrow flow cytometry results available for review. Abnormal lymphoblast populations were detected in four patients (7%) comprising 0.05–0.19% of bone marrow events. The immunophenotype was similar but distinct from haematogones. The most common distinguishing features of the abnormal lymphoblast populations were abnormally bright expression of CD19 or CD10, weak CD38 or aberrant CD20 expression on CD34 + cells. The clinical case of one of the patients with abnormal lymphoblasts detected at diagnosis who went on to subsequent blast crisis is discussed. Abnormal lymphoblasts can be identified in CML-CP and may be under-recognised. Their detection requires careful analysis in order to distinguish them from normal precursors. The clinical significance of such populations requires further study.
Obtaining EPA-rich polar lipids from microalga Nannochloropsis sp. by silica-gel chromatography using non-toxic solvents
Authors: Sánchez María D. Macías , Callejón María J. Jiménez , Medina Alfonso Robles , Moreno Pedro A. González , López Elvira Navarro , Cerdán Luis Esteban , Grima Emilio Molina 
Published: March 2022

Abstract
Current research indicates that n-3 polyunsaturated fatty acids (PUFAs) bind to polar lipids (phospholipids and glycolipids) seem to exert a greater bioavailability compared to their neutral forms. The aim of this work was to obtain eicosapentaenoic acid (EPA) rich polar lipids from the saponifiable lipids (SLs) extracted from the microalga Nannochloropsis sp. (33.4 ± 0.1% of EPA; 60 ± 0.6% polar lipids) by fractionation using silica-gel columns and importantly, non-polar and polar (ethanol) non-toxic solvents. Nowadays, few studies have been conducted towards the extraction and purification of polar lipids. Firstly, the solvent type for obtaining the neutral saponifiable lipid (NSL) fraction (ethyl acetate, EA, butyl acetate, BA) and the SL/silica-gel, SL/BA, and SL/ethanol ratios were optimized in a small silica-gel cartridge (0.69 g silica gel). The optimized conditions were an SL/silica-gel ratio of 22.6 mg/g, an SL/BA ratio of 1.56 mg/mL and an SL/ethanol ratio of 0.312 mg/mL. Next, the fractionation scale was increased to a column containing 10 g of silica-gel. At this scale, a BA SL fraction was obtained with 96.2 ± 0.5% of NSLs, and an ethanol SL fraction containing 97.7 ± 0.3% of polar lipids and 44.9 ± 0.2% of EPA. In the ethanol fraction, 86.6 ± 0.2% of the polar lipids and 71.5 ± 0.4% of the EPA from the SL microalgal extract were recovered. Consequently, EPA-rich polar lipids were obtained at high yields and purities, which could be used as a source of n-3 PUFAs with greater bioavailability than those based on neutral lipids.
A Comparison of the Sealing, Forming and Moisture Vapour Transmission Properties of Polylactic Acid (PLA), Polyethene (PE) and Polyethylene Terephthalate (PET) Coated Boards for Packaging Applications
Authors: McCurdy Conor , Dixion Dorian , Archer Edward , Dooher Thomas , Edwards Ian 
Published: March 2022

AbstractDue to the waste problems associated with plastic packaging and the desire to reduce fossil fuel-based packaging, many retailers and brand owners have set ambitious targets to reduce the use of non-renewable polymers. One aspect of this trend has been an increase in the use of bio-coated boards as an alternative to boards coated with traditional petroleum-based polymers such as PE and PET. This paper identifies the polymers used in a number of commercial boards coated with conventional or biopolymers and compares their performance in terms of the moisture vapour barrier, sealing behaviour, and their ability to be folded without cracking. It was found that PLA was the biopolymer used to coat the two bioboards studied, and while it compares favourably to PE and PET coated boards in terms of heat sealing capabilities, it has potential conversion issues due to it’s brittleness and has inferior moisture barrier properties compared to traditional petroleum-based coated boards.
Investigation of the effect of mineral additives on concrete strength using ANN
Authors: Al-Gburi Majid , Yusuf Salim A. 
Published: March 2022

AbstractIn addition to cement, sand, gravel, and water, the current investigation of the influence of additives on the compressive strength of concrete at 28 days includes fly ash, silica fume, and slag. 315 concrete compositions with various amounts of additives are trained and tested using an artificial neural network. Concrete strength is largely affected by the specific gravity of cement and the specific gravity of fine and coarse particles, according to the studies. For greater compressive strength, it is preferable to use materials with a higher specific gravity. Compressive strength has grown as the amount of silica fumes has increased. Increased amounts of slag or superplasticizer resulted in the same behavior. When the amount of fly ash was increased, the compressive strength of the material decreased.
Defining a Global Map of Functional Group-Based 3D Ligand-Binding Motifs
Authors: Yang Liu , He Wei , Yun Yuehui , Gao Yongxiang , Zhu Zhongliang , Teng Maikun , Liang Zhi , Niu Liwen 
Published: March 2022

Abstract
Uncovering conserved 3D protein–ligand binding patterns on the basis of functional groups (FGs) shared by a variety of small molecules can greatly expand our knowledge of protein–ligand interactions. Despite that conserved binding patterns for a few commonly used FGs have been reported in the literature, large-scale identification and evaluation of FG-based 3D binding motifs are still lacking. Here, we propose a computational method, Automatic FG-based Three-dimensional Motif Extractor (AFTME), for automatic mapping of 3D motifs to different FGs of a specific ligand. Applying our method to 233 naturally-occurring ligands, we define 481 FG-binding motifs that are highly conserved across different ligand-binding pockets. Systematic analysis further reveals four main classes of binding motifs corresponding to distinct sets of FGs. Combinations of FG-binding motifs facilitate the binding of proteins to a wide spectrum of ligands with various binding affinities. Finally, we show that our FG–motif map can be used to nominate FGs that potentially bind to specific drug targets, thus providing useful insights and guidance for rational design of small-molecule drugs.
Comprehensiveness of Online Information in Gender-Affirming Surgery: Current Trends and Future Directions in Academic Plastic Surgery
Authors: Aryanpour Zain , Nguyen Christine T. , Blunck Conrad K. , Cooper Kasey M. , Kovac Stefan , Ananthasekar Shivani , Peters Blair R. 
Published: March 2022

ABSTRACTBackgroundDespite high rates of online misinformation, transgender and gender diverse (TGD) patients frequently utilize online resources to identify suitable providers of gender-affirming surgical care.AimThe objective of this study was to analyze the webpages of United States academic plastic surgery programs for the types of gender-affirming surgery (GAS) procedures offered and to determine how this correlates with the presence of an institutional transgender health program and geographic region in order to identify potential gaps for improvement.MethodsOnline institutional webpages of 82 accredited academic plastic surgery programs were analyzed for the presence of the following: GAS services, specification of type of GAS by facial, chest, body and genital surgery, and presence of a concomitant institutional transgender health program. This data was analyzed for correlations with geographic region and assessed for any significant associations.OutcomesFrequencies of GAS services, specification of the type of GAS by facial, chest, body and genital surgery, presence of a concomitant institutional transgender health program, and statistical correlations between these items are the primary outcomes.ResultsOverall, 43 of 82 (52%) academic institutions offered GAS. Whether an institution offered GAS varied significantly with the presence of an institutional transgender health program (P &lt; .001) but not with geographic region (P = .329). Whether institutions that offer GAS specified which anatomic category of GAS procedures were offered varied significantly with the presence of an institutional transgender health program (P &lt; .001) but not with geographic region (P = .235).Clinical ImplicationsThis identifies gaps for improved transparency in the practice of communication around GAS for both physicians and academic medical institutions.Strengths & LimitationsThis is the first study analyzing the quality, content, and accessibility of online information pertaining to GAS in academic institutions. The primary limitation of this study is the nature and accuracy of online information, as current data may be outdated and not reflect actuality.ConclusionBased on our analysis of online information, many gaps currently exist in information pertaining to GAS in academic settings, and with a clear and expanding need, increased representation and online availability of information regarding all GAS procedure types, as well as coordination with comprehensive transgender healthcare programs, is ideal.
The Metaphysics of the Narrative Self
Authors: REA MICHAEL 
Published: March 2022

AbstractThis essay develops a theory of identities, selves, and ‘the self’ that both explains the sense in which selves are narratively constituted and also explains how the self relates to a person's individual autobiographical identity and to their various social identities. I argue that identities are the contents of narratively structured representations, some of which are hosted individually and are autobiographical in form, and others of which are hosted collectively and are biographical in form. These identities, in turn, give rise to selves of various sorts—true selves, autobiographical selves, public and private selves, merely possible selves, and so on—which are the characters (or presupposed subjects) that appear in our various identities. Although the theory I develop bears some obvious affinities with the view that selves are fictional characters, the two views are in fact distinct, for reasons explained at the end.
Effectiveness of an electronic health system−based best-practice advisory to enhance the time to de-escalation of vancomycin for respiratory indications
Authors: Gibbs Amanda C. , Jackson Daniel A. , Runjaic Senka , Toncray Vanessa J. , Bosch Wendelyn , Mendez Julio C. , Epps Kevin L. 
Published: March 2022

Abstract

Objective:
Methicillin-resistant Staphylococcus aureus (MRSA) infection is highly unlikely when nasal-swab results are negative. We evaluated the impact of an electronic prompt regarding MRSA nasal screening on the length of vancomycin therapy for respiratory indications.

Design:
Retrospective, single-center cohort study.

Setting:
Tertiary-care academic medical center (Mayo Clinic) in Jacksonville, Florida.

Patients:
Eligible patients received empiric treatment with vancomycin for suspected or confirmed respiratory infections from January through April 2019 (preimplementation cohort) and from October 2019 through January 2020 (postimplementation cohort).

Intervention:
The electronic health system software was modified to provide a best-practice advisory (BPA) prompt to the pharmacist upon order verification of vancomycin for patients with suspected or confirmed respiratory indications. Pharmacists were prompted to order a MRSA nasal swab if it was not already ordered by the provider.

Methods:
We reviewed patient records to determine the time from vancomycin prescription to de-escalation. The secondary end point was incidence of acute kidney injury.

Results:
The study included 120 patients (preimplementation, n = 61; postimplementation, n = 59). Median time to de-escalation was significantly shorter for the postimplementation cohort: 76 hours (interquartile range [IQR], 52–109) versus 42 hours (IQR, 37–61; P = .002). Acute kidney injury occurred in 11 patients (18%) in the preimplementation cohort and in 3 patients (5%) in the postimplementation cohort (P = .01; number needed to treat, 8).

Conclusions:
Implementation of a BPA notification for MRSA nasal screening helped decrease the time to de-escalation of vancomycin.
Adherence to Anticoagulation Interruption Guidelines in Patients with Atrial Fibrillation
Authors: Siddique Mujtaba , Butt Asif , Sultan Nazeem , Ahmed Farhat , Shuaib Ashfaq 
Published: March 2022

ABSTRACT:Introduction:Annually, 15% of patients who receive oral anticoagulation require interruption for surgery or an invasive procedure. This study evaluates the adherence of patients with atrial fibrillation with a history of stroke or transient ischemic attack to the Thrombosis Canada Perioperative guidelines for the discontinuation and reinitiation of anticoagulation treatment.Methods:We collected data from a prospective patient survey at the Stroke Prevention Clinic in the University of Alberta hospital. Patients’ charts were reviewed from the electronic medical records, and adherence was looked at according to the Thrombosis Canada Perioperative guidelines for the interruption of anticoagulants.Results:During the study period (2016–2019), there were 509 patients surveyed. Anticoagulation treatment was interrupted in 150 patients with 98 interrupted for surgical or invasive procedures. The interruption was adherent to guidelines in only 29 (29.6%) of patients and inappropriate or nonadherent in 69 (70.4%) patients. There were seven ischemic strokes recorded during the period of interruption. The proportion of strokes was higher in patients whose anticoagulation interruption was longer than what the guidelines recommended (6/61 or 9.8%) when compared to those who adhered to recommended perioperative anticoagulation guidelines (1/29 or 3.4%).Conclusion:Our results indicate that significant discrepancy with following the recommended perioperative anticoagulation guidelines is common in real-life practice. Delay in re-anticoagulation may increase the risk of complications.
A drastic change in glacial dynamics at the beginning of the seventeenth century on Novaya Zemlya coincides in time with the strongest volcanic eruption in Peru and the Great Famine in Russia
Authors: Rusakov Valeriy , Kuz'mina Тat'yana , Borisov Alexander , Gromyak Irina , Dogadkin Denis , Romashova Тat'yana , Solovi'eva Galina , Lukmanov Ruslan 
Published: March 2022

AbstractIn this study, we reconstructed for the first time the recent 1000-yr-long history of Goluboi tidewater glacier at the eastern side of the Novaya Zemlya, Kara Sea, based on accelerator mass spectrometry 14C dating with higher-resolution age control on the basis of 210Pb and 137Cs radionuclides for the time period after AD 1885, using multiproxy analyses (lithology, mineralogy, and geochemistry) of proximal glaciomarine sediments from the Oga Fjord. Against the background of the active glacial dynamics and the intense meltwater runoff until the end of the sixteenth century, there was a sudden cooling at the beginning of the seventeenth century, which manifested itself in a significant decrease in the sedimentation rates. In time, this event coincides with the strongest volcanic eruption, AD 1600, in South America (in Peru) in the history of human settlement of the continent, which may have plunged the globe into cold climate chaos (Witze, 2008), and caused the Great Famine, AD 1601 to AD 1603, in Russia. The synchronicity of the described events may be an additional fact confirming the global impact of the eruption on the climate of our planet.
Pleistocene small-mammal and arthropod trackways from the Cape south coast of South Africa
Authors: Lockley Martin G. , Helm Charles W. , Cawthra Hayley C. , De Vynck Jan C. , Dixon Mark G. , Venter Jan A. 
Published: March 2022

AbstractA trackway and burrows of a small rodent-sized bounding mammal (attributed to the Cape gerbil,Gerbilliscus afra) and a traceway of a large arachnid (spider) from the Pleistocene Waenhuiskrans Formation represent two biological groups not previously reported from this track-rich dune facies, which is widely distributed along the Cape south coast of South Africa. This may be due to biases against the preservation of small tracks. Trackways of hopping or bounding rodent-sized mammals are rare in the fossil record, occurring at only two known Mesozoic sites and three Cenozoic sites. Where these occur in dune facies, they are commonly associated with arachnid and other arthropod surface trails. The arachnid trace fossils commonly include the spider tracewayOctopodichnus, known from the Permian to Recent, which is also the temporal range of the eponymousOctopodichnusichnofacies. The abundance of small-mammal tracks associated with dune ichnofaunas led to the naming of the late Palaeozoic and MesozoicChelichnusichnofacies, which is largely co-extensive with theOctopodichnusichnofacies at this time. However, the recognition of similar mammal–arthropod dune facies assemblages in the Cenozoic requires adjusting our understanding of their distribution in space and time, and extends the known distribution of dune ichnofacies.
Quality appraisal of clinical nutrition practice guidelines for critically ill adult patients: a systematic review using the Advancing Guideline Development, Reporting and Evaluation in Health Care instrument II (AGREE-II) and AGREE-Recommendation Excellence (AGREE-REX)
Authors: Cattani Aline , Teixeira Paula Portal , Eckert Igor da Conceição , Busnello Fernanda , Gabriel Franciele , Stein Airton , Silva Flávia Moraes 
Published: March 2022

AbstractNutritional therapy should follow evidence-based practice, thus several societies regarding nutrition and critical care have developed specific Clinical Practice Guidelines (CPG). However, to be regarded as trustworthy, the quality of the CPG for critically ill patients and its recommendations need to be high. This systematic review aimed to appraise the methodology and recommendations of nutrition CPG for critically ill patients. We performed a systematic review (protocol number CRD42020184199) with literature search conducted on PubMed, Embase, Cochrane Library and other four specific databases of guidelines up to October 2021. Two reviewers, independently, assessed titles and abstracts and potentially eligible full-text reports to determine eligibility and subsequently four reviewers appraised the guidelines quality using the Advancing Guideline Development, Reporting and Evaluation in Health Care instrument II (AGREE-II) and AGREE-Recommendation Excellence (AGREE-REX). Ten CPG for nutrition in critically ill patients were identified. Only Academy of Nutrition and Dietetics and European Society of Intensive Care Medicine had a total acceptable quality and were recommended for daily practice according AGREE-II. None of the CPG recommendations had an overall quality score above 70 %, thus being classified as moderate quality according AGREE-REX. The methodological evaluation of the critically ill adult patient CPG revealed significant discrepancies and showed a need for improvement in its development and/or reporting. In addition, recommendations about nutrition care process presented a moderate quality.
Timing of infant formula introduction in relation to BMI and overweight at ages 1 and 3 years: the Born in Guangzhou Cohort Study (BIGCS)
Authors: Yuan Mingyang , Lu Minshan , Guo Yixin , Lam Kin Bong Hubert , Lu Jinhua , He Jianrong , Shen Songying , Wei Dongmei , Thomas G. Neil , Cheng Kar Keung , Qiu Xiu 
Published: March 2022

AbstractMounting evidence suggests that the first few months of life are critical for the development of obesity. The relationships between the timing of solid food introduction and the risk of childhood obesity have been examined previously; however, evidence for the association of timing of infant formula introduction remains scarce. This study aimed to examine whether the timing of infant formula introduction is associated with growth z-scores and overweight at ages 1 and 3 years. This study included 5733 full-term (≥ 37 gestational weeks) and normal birth weight (≥ 2500 and < 4000 g) children in the Born in Guangzhou Cohort Study, a prospective cohort study with data collected at 6 weeks, 6, 12 and 36 months. Compared with infant formula introduction at 0–3 months, introduction at 4–6 months was associated with the lower BMI, weight-for-age and weight-for-length z-scores at 1 and 3 years old. Also, introduction at 4–6 months was associated with the lower odds of at-risk of overweight at age 1 (adjusted OR 0·72, 95 % CI 0·55, 0·94) and 3 years (adjusted OR 0·50, 95 % CI 0·30, 0·85). Introduction at 4–6 months also decreased the odds of overweight at age 1 year (adjusted OR 0·42, 95 % CI 0·21, 0·84) but not at age 3 years. Based on our findings, compared with introduction within the first 3 months, introduction at 4–6 months has a reduction on later high BMI risk and at-risk of overweight. However, these results need to be replicated in other well-designed studies before more firm recommendations can be made.
Un constructivisme enraciné : élucidation, ontologie et création de concepts chez Cornelius Castoriadis
Authors: Tranchant Thibault 
Published: March 2022

RésuméJean-Marc Ferry objectait à Cornelius Castoriadis que sa philosophie repose sur une décision ontologique arbitraire transgressant les limites de la critique kantienne de la raison. Dans cet article, je réponds à cette objection en commentant l'opération méthodologique sur laquelle repose l'ontologie de Castoriadis : l’élucidation. Je montre qu'elle ne dépasse pas les limites prescrites par la finitude kantienne et qu'elle lui permet de justifier ses concepts ontologiques. J'explique ensuite dans quelle mesure on peut qualifier la méthode de Castoriadis de « constructivisme enraciné » et quel est son apport pour les théories philosophiques constructivistes.
Rare case of anomalous origin of the left coronary artery from the pulmonary artery in a 4-year-old child
Authors: Landry Lily M. , Osakwe Onyekachukwu , Arya Sandeep 
Published: March 2022

AbstractAnomalous origin of the left coronary artery from the pulmonary artery is an exceedingly rare and potentially fatal congenital coronary anomaly that typically presents early in infancy. We report an unusual case of anomalous origin of the left coronary artery from the pulmonary artery in a 4-year-old child who presented later in life with vague respiratory and gastrointestinal symptoms and was found to have severe global cardiac dysfunction with evidence myocardial ischaemia.