bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency of chemotherapy GemCap + mitotane as second and subsequent lines of therapy for metastatic adrenocortical cancer
Authors: Zhulikov Ya. A. , Kovalenko E. I. , Bokhyan V. Yu. , Khoroshilov M. V. , Goryainov D. A. , Roslyakova A. A. , Magamedova S. S. , Evdokimova E. V. , Artamonova E. V. 
Published: September 2022

Background. Combination of gemcitabine, metronomic capecitabine and mitotane (GemCap + m) is the most studied regimen in second and subsequent lines of therapy for advanced adrenocortical cancer (ACC). Previously published studies do not give a definitive answer to the question- what plays a key role in realizing the response to treatment: chemotherapy or mitotane in therapeutic concentration.Aim. Evaluation the efficacy and safety of GemCap + m combination with the standard dosing regimen of capecitabine in patients with metastatic ACC.Materials and methods. This retrospective single-center clinical study included patients over 18 years of age with histologically confirmed ACC with disease progression after completion of platinum-containing therapy. They received chemotherapy regimen gemcitabine 800 mg/m2 for days 1, 8 and capecitabine 1000 mg/m2 orally 2 times at days 1–14 of the 21-day cycle with mitotane. we evaluated objective response, stabilization of disease, 6-months disease control rate and median progression-free and overall survival. Radiological assessment according to RECIST 1.1 criteria was carried out every 6–8 weeks of treatment.Results. The study included 25 patients. mitotane concentration above 14 ng/mL was achieved in 22 (88 %) patients, of which 21 (84 %) reached therapeutic concentration in previous treatment lines. 80 % of patients received treatment as 2nd line, 20 % as 3rd and subsequent lines. The objective responses and disease stabilization was observed in 1 (4 %) and 11 (44 %) of patients, respectively. Disease control for at least 6 months rate was 24 %. median progression-free and overall survival were 3.2 months and 12.17 months, respectively. Toxicity grade 3–4 was observed in 28 % of patients. gemcitabine dose reductions due to thrombocytopenia grade 1–2 were required in 2 cases (8 %), no capecitabine reductions were necessary.Conclusion. This study demonstrates the effectiveness of a new dose regimen of chemotherapy GemCap + m in the second and subsequent lines of therapy for metastatic ACC. The progression of the disease against the background of previous lines of therapy at a therapeutic concentration of mitotane in the majority of patients indicates the effectiveness of the chemotherapeutic component of gemCap in a cohort of patients resistant to platinum and mitotane.
Analysis of acne relapses in women after systemic retinoid therapy
Authors: Elkin V. D. , Kobernik M. Yu. , Kuznetsov I. D. 
Published: September 2022

Objective. To analyze the conditions and factors contributing to the development of acne recurrence after therapy with systemic retinoids. Acne is a chronic inflammatory dermatosis characterized by the formation of open and closed comedones, papules, pustules, nodes on skin areas rich in sebaceous glands, significantly disrupting the quality of life of patients. The most effective drugs for its treatment are systemic retinoids. They allow one to achieve complete cleansing of the skin, but even after their use relapses of the disease are possible.
Materials and methods. The study involved 65 women 1 year after the end of acne treatment with systemic retinoids, who were divided into two groups: group I was formed by 30 women with the development of acne relapses; group II included 35 women without acne relapses. The exclusion criteria were the following: severe endocrine pathology, the presence of cardiovascular diseases, liver disease, pregnancy and lactation, alcoholism, smoking. The study consisted of general clinical techniques and standard laboratory methods, including biochemical blood analysis with the determination of lipid and carbohydrate metabolism, the level of pituitary hormones and sex hormones. Methods of parametric and nonparametric statistics were used to account for and analyze the results.
Results. In half of the cases, acne relapses were observed after a new coronavirus infection; much less often, in equal proportions, they developed after stress and menstrual cycle failure, there were patients who could not identify the factors preceding the recurrence of acne. The average age of patients with acne relapses after treatment with systemic retinoids was 24.6 2.4 years, patients without acne relapses after appropriate therapy 17.3 1.8 years (p = 0.028). Burdened heredity for acne, combination of acne with seborrheic dermatitis and/or menstrual dysfunction by the type of menstrual arrhythmia were significantly more often determined in patients with acne relapses after therapy with systemic retinoids. In the same group, lipid metabolism disorders and hormonal changes in the form of increased levels of progesterone and androgens were observed significantly more often.
Conclusions. Acne, even after the therapy with systemic retinoids, can have a recurrent course. The main external factor, preceding relapse is a new coronavirus infection. Relapses after acne treatment with systemic retinoids are developed against the background of burdened heredity for acne, changes in lipid metabolism, persistent imbalance of sex hormones, as well as when acne is combined with seborrheic dermatitis. For pubertal acne without pronounced metabolic and endocrine changes, relapses after therapy with systemic retinoids are not typical.
Effectiveness of complex treatment associated with ozone therapy on clinical indicators and immunity status in children with atopic dermatitis and concomitant allergic rhinitis
Authors: Illek Ya. Yu. , Suetina I. G. , Khlebnikova N. V. , Suslova E. V. , Galanina A. V. 
Published: September 2022

Objective. To evaluate the effectiveness of complex treatment in combination with ozone therapy in children with moderate atopic dermatitis and concomitant moderate persistent allergic rhinitis.
Materials and methods. Under observation were children of preschool and primary school age with moderate atopic dermatitis and concomitant moderate persistent allergic rhinitis. In these children, we studied clinical indicators, the content of populations and subpopulations of lymphocytes in the blood, immunoglobulins and circulating immune complexes in the blood serum, phagocytosis indicators, expression of toll-like receptors on leukocytic cells. Patients were divided into two groups depending on the therapy. The first group received complex conventional therapy, the second group received complex treatment in combination with ozone therapy.
Results. It was found that in the first group of patients during the period of clinical remission, changes in immunological reactivity persisted. In the second group of patients, a more rapid onset of clinical remission was recorded, during which normalization of most immunity parameters was noted. The duration of complete clinical remission in the second group of patients more than twofold exceeded its duration in the first group of patients.
Conclusions. The inclusion of ozone therapy in complex treatment of preschool and primary school children suffering from moderate atopic dermatitis and concomitant moderate persistent allergic rhinitis provides a more rapid onset of clinical remission. During the period of clinical remission, normalization of most immunity parameters, a pronounced increase in the expression of toll-like receptors-2 and toll-like receptors-6 on lymphocytes, monocytes and neutrophils are recorded. This indicates an increase in nonspecific antibacterial resistance. Conducting a repeated course of complex treatment in combination with ozone therapy ensures the preservation of complete clinical remission, the duration of which is twice as long as in the first group. High therapeutic effect of ozone, the availability of ozone therapy, the absence of complications and adverse reactions when using complex treatment in combination with ozone therapy allow us to recommend the widespread use of this method in children of preschool and primary school age suffering from moderate atopic dermatitis and concomitant moderate persistent allergic rhinitis.
Pengembangan Bahan Ajar BIPA: Membaca untuk Pemula Bermuatan Budaya Jawa Timur
Authors: Proklawati Desy , Roekhan Roekhan , Susanto Gatut 
Published: September 2022

<p><strong>Abstract: </strong>This research was conducted with the aim of (1) Producing BIPA teaching materials: reading for beginners (A1) containing East Javanese culture. This study uses a research design using the Research and Development (R &amp; D) development model which refers to the ADDIE development model consisting of 5 main steps, namely: Analysis, Design, Development, Implementation, and Evaluation. Based on the research results, it was concluded (1) the results of the validation of the material experts obtained a validity value of 91% and were included in the valid and suitable criteria for learning, (2) the results of the design expert validation obtained a validity value of 96% and entered into valid criteria and suitable for learning (3) validation results Overall, the validity value is 94% and is included in the valid and suitable criteria for learning, (4) Practitioners' responses obtained a value of 94.00% and were declared feasible and accepted as teaching materials.</p><strong>Abstrak:</strong> Penelitian ini dilaksanakan dengan tujuan menghasilkan bahan ajar BIPA membaca untuk pemula (A1) bermuatan budaya Jawa Timur. Penelitian ini menggunakan rancangan penelitian menggunakan model pengembangan <em>Research and Development</em> (R&amp;D) yang merujuk pada model pengembangan ADDIE ini terdiri dari lima langkah utama, yaitu <em>Analysis</em> (Analisis), <em>Design</em> (Perancangan), <em>Development</em> (Pengembangan), <em>Implementation</em> (Implementasi), dan <em>Evaluation</em> (Evaluasi). Berdasarkan hasil penelitian diperoleh kesimpulan (1) hasil validasi ahli materi diperoleh nilai kevalidan mencapai 91% dan masuk dalam kriteria valid dan layak digunakan untuk pembelajaran, (2) hasil validasi ahli desain diperoleh nilai kevalidan mencapai 96% dan masuk dalam kriteria valid dan layak digunakan untuk pembelajaran, (3) hasil validasi secara keseluruhan diperoleh nilai kevalidan mencapai 94% dan masuk dalam kriteria valid dan layak digunakan untuk pembelajaran, dan (4) tanggapan praktisi diperoleh nilai 94,00% dan dinyatakan layak dan diterima sebagai bahan ajar.<strong> </strong>
The Effect of Using Youtube Videos on Students’ Writing Descriptive Text Across Learning Styles
Authors: Felanie Rakhmad 
Published: September 2022

<p><strong>Abstract:</strong> Investigating the effect of using Youtube videos toward student’s writing descriptive text across student’s learning styles is the objective of this research. The research is quasi-experimental factorial research. Non-randomized sampling technique was applied in this research. The sample of the research were 10<sup>th </sup>grade of Multimedia 1 class student. The Instrument used in this research were pretest and posttest as means to measure students’ writing achievement, and questionnaire as means to identify students’ learning styles. Two way Anova (Analysis of Variance) was used to analyze the data. It was found that the achievement of students who were taught using Youtube videos were higher than the students who were not taught by using Youtube videos. Writing achievement of visual learning style students were better than auditory learning style students in experimental class. It was also found that the significant value of interaction between the usage Youtube videos and student writing achievement was .04. The significant level was less than .05 (04&lt; .05). However, learning style has no effect to writing achievement.</p><strong>Abstrak: </strong>Meneliti pengaruh penggunaan video YouTube terhadap prestasi menulis teks deskriptif siswa dihubungkan dengan gaya belajar mereka adalah tujuan dari penelitian ini. Peneliatian ini adalah penelitian kuasi eksperimental. Sampel non acak diterapkan dalam penelitian ini. Sampel dari penelitian adalah siswa kelas 10 Multimedia. Instrument yang dipakai dalam penelitian ini adalah pretest dan posttest sebagai alat mengukur prestasi menulis siswa dan angket sebagai alat mengidentifikasi gaya belajar siswa. Two way Anova digunakan untuk menganalisa data. Ditemukan bahwa prestasi siswa yg diajar menggunakan video YouTube lebih baik prestasinya daripada siswa yang tidak menggunakan video YouTube. Prestasi menulis siswa gaya belajar visual lebih baik daripada siswa gaya belajar audio di dalam grup ekperimental. Ditemukan juga nilai signinfikan dari interaksi antara penggunaan video YouTube dan prestasi menulis siswa sebesar 0.4. Level signifikan kurang dari .05 (04&lt; .05). Akan tetapi, <em>learning</em> <em>style </em>tidak berpengaaruh kepada prestasi menulis.
Adopsi Nilai Moral Panton Aceh Dalam Focus Group Discussion sebagai Teknik Konseling Model KIPAS
Authors: Afriadi Nasrizal , Mappiare-AT Andi , Muslihati Muslihati 
Published: September 2022

<div align="center"><table class="KisiTabel1" width="645" border="1" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="439"><p><strong>Abstract:</strong> This a research constructs of the focus group discussion with moral values in Panton Aceh to develop a new technique based on local culture, namely the Panton Aceh culture so that this a technique can be an effective and attractive to be used in the group counseling of setting service, so that guidance counseling teachers can helped to do group counseling services at the school. In the process of implementing focus group discussion technique containing Panton Aceh, following the model counseling steps KIPAS consisting of kabar gembira (good news), integrasi data, perencanaan kegiatan (plan of action), aktualiasi kegiatan (actualization of plan), and selebrasi (celebrtion). The focus of this research is how the description of moral values that can be taken in Panton Aceh and how the construction of moral values in Panton Aceh that can be adopted becomes the content of the focus group discussion technique to modify student character. The method used in this study is qualitative with the type of research Hemeneutika Gradamerian. The results of a research study, there are found that five moral values contained in Panton Aceh, namely humility, honesty, hard work, self control, and love to share. Next, the researcher constructs the implementation of focus group discussion techniques with moral values in the Panton Aceh.</p><p><strong>Abstrak:</strong><em> </em>Penelitian ini mengonstruksikan teknik focus group discussion bermutan nilai moral dalam Panton Aceh untuk menggembangkan teknik baru yang berbasis budaya lokal yaitu budaya Panton Aceh supaya tenik ini dapat menjadi salah satu teknik yang efektif dan menarik untuk digunakan dalam setting layanan konseling kelompok, sehingga guru bimbingan konseling dapat terbantu untuk melakukan layanan konseling kelompok di sekolah. Dalam proses pelaksanaan teknik focus group discussion bermuatan Panton Aceh mengikuti langkah-langkah konseling model KIPAS yang terdiri dari kabar gembira, integrasi data, perencanaan kegiatan, aktualisasi kegiatan dan selebrasi. Fokus penelitian ini adalah bagaimanakah deskripsi nilai moral yang dapat diambil dalam Panton Aceh dan bagaimanakah konstruksi nilai moral dalam Panton Aceh yang dapat di adopsi menjadi isi teknik focus group discussion untuk memodifikasi karakter siswa. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan jenis penelitian Hemeneutika Gradamerian. Hasil kajian penelitian, peneliti menemukan ada lima nilai moral yang terdapat dalam Panton Aceh yaitu rendah hati, kejujuran, kerja keras, kontrol diri, dan gemar berbagi. Selanjutnya peneliti mengkonstruksi pelaksanaan teknik focus group discussion bermuatan nilai moral dalam Panton Aceh.</p></td></tr></tbody></table></div>
Manajemen Pembelajaran Guru Sekolah Dasar Islam Terpadu Pada Masa COVID-19
Authors: Sulastri Sulastri , AR Murniati , Usman Nasir 
Published: September 2022

<div align="center"><table width="645" border="1" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="439"><p><strong>Abstract:</strong> This study aims to describe the learning management of Ibn Mas'ud integrated Islamic elementary school teachers, Pidie Regency, during the Covid-19 pandemic. The research method used is a qualitative method with a descriptive approach and data obtained from observations, interviews and relevant literature studies. This study found that learning planning by the Ibn Mas'ud Integrated Islamic Elementary School teacher conducted in a participatory manner by involving all education stakeholders. Then, the teachers' learning implementation and evaluation structured, and teachers also optimize students' parents' roles. Thus, the learning management implementation has a positive impact on teaching and learning activities even in the covid-19 pandemic.</p><p class="Abstract"><strong>Abstrak:</strong><em> </em>Penelitian ini bertujuan untuk mendeskripsikan tentang manajemen pembelajaran guru Sekolah Dasar Islam Terpadu Ibnu Mas’ud Kabupaten Pidie pada masa darurat Covid-19. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan deskriptif, dan diperoleh dari hasil observasi, wawancara, dan studi literatur yang relevan. Hasil penelitian ini menunjukkan bahwa perencanaan pembelajaran oleh guru Sekolah Dasar Islam Terpadu Ibnu Mas’ud dilakukan secara partisipatif dengan melibatkan semua <em>stakeholder</em> pendidikan yang ada di sekolah. Implementasi dan evaluasi pembelajaran oleh guru juga dilaksanakan secara partisipatif dan guru mampu mengoptimalkan peran orangtua siswa. Dengan demikian, dapat disimpulkan bahwa pengaplikasian manajemen pembelajaran berdampak positif pada kegiatan belajar mengajar meskipun dalam kondisi pandemi covid-19.</p></td></tr></tbody></table></div>
Berbahasa Fatis Dalam Interaksi Sosial di Pesantren (Kajian Etnografi Komunikasi)
Authors: Risnawati Risnawati , Ibrahim Abdul Syukur , Saryono Djoko 
Published: September 2022

<p><strong>Abstract:</strong> This qualitative study with the ethnographic design of communication aims to clarify the manifestations of phatic language in social interaction in <em>Pesantren</em>. Ethnographic communication research emphasizes the existence of culture, language and other factors in the community. The data of this study is a speech containing a vivid language of social interaction in an Islamic boarding school. Speech data containing fat language were then transcribed using written text with contextual explanations. The data of this study were taken from July 12, 2019 to December 20, 2019. The source of this research was 16 female students, 3 religious teachers and 2 religious teachers at Al Irtiqo Islamic boarding school in Malang. The results of the study found forty-nine data related to the three unity language focus, namely (1) form, (2) function, and (3) form and function strategy.</p><strong>Abstrak:</strong><em> </em>Penelitian kualitatif dengan desain etnografi komunikasi ini bertujuan untuk mendeskripsikan wujud bahasa fatis dalam interaksi sosial di pondok pesantren. Penelitian etnografi komunikasi menekankan pada adanya keterkaitan budaya, bahasa, dan faktor lain dalam lingkungan sekitar masyarakat. Data penelitian ini berupa tuturan yang mengandung bahasa fatis dalam interaksi sosial di pondok pesantren. Data tuturan yang mengandung bahasa fatis kemudian ditranskrip ke dalam teks tulis beserta penjelasan konteksnya. Data penelitian ini diambil dari 12 Juli 2019 sampai 20 Desember 2019. Sumber data penelitian ini adalah 16 santri putri, 3 ustaz dan 2 ustazah di pondok pesantren putri Al Irtiqo’ Malang. Hasil penelitian ditemukan tiga fokus bahasa fatis yang memiliki sembilan puluh empat data secara <em>unity</em>, yaitu (1) wujud, (2) fungsi, dan (3) strategi bahasa fatis.
Tindak Tutur Direktif dalam Khotbah Pendeta di Gereja Kristen Protestan Kota Malang
Authors: Bongo Ade Rikky , Ibrahim Abd. Syukur , Susanto Gatut 
Published: September 2022

<p><strong>Abstract:</strong> This study aims to describe the use of directive speech acts in the context of Protestant Christian sermons. This research is a type of pragmatic research that examines the meaning of a speech in a particular context. The data source of this research was obtained from reverend sermons in five churches in Malang. The results showed that the preaching speech of the reverend in a Protestant Christian church in Malang used directive speech acts to express order to the congregation. These orders are studied based on the form of directive speech, the function of directive speech, and the strategy for delivering a directive speech. </p><strong>Abstrak:</strong><em> </em>Penelitian ini bertujuan untuk mendeskripsikan penggunaan tindak tutur direktif dalam konteks khotbah keagamaan Kristen Protestan. Penelitian ini merupakan jenis penelitian pragmatik yang mengkaji makna dari sebuah tuturan dalam konteks tertentu. Sumber data penelitian ini diperoleh dari tuturan khotbah pendeta di lima gereja yang berada di Kota Malang. Hasil penelitian menunjukkan bahwa tuturan khotbah pendeta di gereja Kristen Protestan yang berada di kota Malang menggunakan tindak tutur direktif untuk menyatakan suatu perintah kepada jemaat. Perintah tersebut dikaji berdasarkan wujud tuturan direktif, fungsi tuturan direktif, dan strategi penyampaian tuturan direktif.
Persepsi Mahasiswa terhadap Pembelajaran Daring Selama Pandemi Covid-19 Berdasarkan Perspektif Gender
Authors: Muzaki Helmi 
Published: September 2022

<p><strong>Abstract:</strong> This study aims to describe student perceptions of online learning during the covid-19 pandemic based on a gender perspective. The method in this study uses a descriptive quantitative approach. The sample of this study amounted to 120 people consisting of 52 men and 68 women. The data analysis technique uses IBM SPSS 26. The results of this study show that there are significant differences in perceptions between men and women in online learning during the Covid-19 pandemic. These differences are: women feel more comfortable answering questions given in online lectures, women prefer to be at home when participating in online learning, and women choose more learning to be done online than men after the Covid-19 pandemic ends.</p><strong>Abstrak:</strong> Penelitian ini bertujuan untuk mendeskripsikan persepsi mahasiswa terhadap pembelajaran daring selama pandemi Covid-19 berdasarkan perspektif gender. Mentode dalam penelitian ini menggunakan pendekatan kuantitatif deskriptif. Sampel penelitian ini berjumlah 120 orang yang terdiri 52 laki-laki dan 68 perempuan. Teknik analisis data menggunakan IBM SPSS 26. Hasil penelitian ini menunjukan terdapat perbedaan persepsi yang signifikan antara laki-laki dan perempuan dalam pembelajaran daring selama pandemi Covid-19. Perbedaan tersebut, yaitu perempuan merasa lebih nyaman menjawab pertanyaan-pertanyaan yang diberikan dalam perkuliahan daring, perempuan lebih suka berada di rumah ketika mengikuti pembelajaran daring dan perempuan memilih lebih banyak pembelajaran dilakukan secara daring daripada laki-laki setelah pandemi Covid-19 berakhir.<strong> <em><br /></em></strong>