bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unpacking EFL Teachers’ TPACK thru the Distance Education
Authors: Imania Sofia , Anugerahwati Mirjam , Tresnadewi Sintha 
Published: September 2022

<p><strong>Abstract:</strong> The growth of distance education provides an accessibility of teaching-and-learning-process involving the use of ICT. Hence, teachers’ competencies regarding the integration of ICT also one of the key success of teaching. Through TPACK, this study aims at investigating EFL teachers’ skills on technology integration and their preferable ICT based learning system amidst distance education. Moreover, this study also intends to analyze whether EFL teachers’ TPACK are significantly different in terms of teaching categories and gender. This survey study implicated 139 in-service EFL teacher in the city of Malang, East Java, Indonesia. The data were collected through questionnaire and analyzed by computing the frequency, ANOVA, and t-test. The finding revealed that the EFL teachers’ TPACK was decent. Furthermore, gender and teaching categories were not regarded as the factors that influenced EFL teachers’ TPACK. Lastly, Google Classroom was perceived as the most preferable ICT based learning system according to the teachers. Regarding the result of analysis, recommendation for teachers and educational stakeholders were also made in this study.</p><strong>Abstrak:</strong> Perkembangan Pendidikan Jarak Jauh (PJJ) menawarkan aksesibilitas proses belajar-mengajar yang sangat melibatkan penggunaan TIK. Karenanya, kompetensi guru terhadap integrasi TIK juga diangap sebagai salah satu kunci keberhasilan pembelajaran. Melalui TPACK, penelitian ini bertujuan untuk menginvestigasi ketrampilan guru EFL terkait integrasi teknologi dan sistem pembelajaran berbasis TIK yang guru EFL gunakan saat Pembelajaran Jarak Jauh (PJJ). Selain itu, penelitian ini juga bermaksud untuk menganalisa perbedaan TPACK guru EFL berdasarkan kategori mengajar dan gender. Penelitian survei ini melibatkan 139 guru EFL di Kota Malang, Jawa Timur, Indonesia. Pengumpulan data dilakukan menggunakan kuesioner dan dianalisa dengan menghitung frekuensi jawaban responden, ANOVA, dan t-test. Hasil penlitian menunjukkan bahwa TPACK guru EFL baik. Kemudian, gender dan kategori mengajar bukanlah faktor yang membedakan TPACK guru EFL. Terakhir, <em>Google Classroom </em>merupakan media pembelajaran yang paling disukai oleh guru. Berdasarkan hasil analisa, rekomendasi untuk guru dan beberapa pihak terkait juga dibuat dalam penelitian ini.
A Design of Interactive Augmented Reality Mobile-Learning Application for iOS-Based Device: Phytochemical Screening Material
Authors: Kristanty Ruth Elenora , Hakiem Nashrul 
Published: September 2022

<p class="Abstrak"><strong>Abstract:</strong> Augmented Reality (AR) in the study of phytochemical screening is a technology that combines observation of experimental results in phytochemical screening as virtual objects with real environments. This study aimed to develop interactive learning media for phytochemical screening materials in the Phytochemistry Practicum at the Pharmaceutical and Food Analysis Department of Poltekkes Kemenkes Jakarta II. This interactive learning media application using AR technology was applied to iOS-based smartphones and designed for phytochemistry learning in the laboratory. The methods used in this study were descriptive exploratory for phytochemistry analysis and Multi-Media Development Life Cycled (MDLC) for AR development. 3D objects were resulting from phytochemical screening of Simplicia powder studied by using blender application, with Unity as a game engine and Vuforia as a library. The development of AR technology resulted in iOS-based mobile application named AR Fitokimia that visualized the phytochemical screening results. The application would help improve students' understanding and participation in distance learning. An interactive AR mobile learning application for iOS-based smartphones was designed for the entire class with an iFamily device in handling distance learning of phytochemical screening in the laboratory.</p><strong>Abstrak:</strong> Augmented Reality (AR) dalam kajian penapisan fitokimia merupakan teknologi yang menggabungkan pengamatan hasil eksperimen penapisan fitokimia sebagai objek virtual dengan lingkungan nyata. Tujuan penelitian ini adalah mengembangkan media pembelajaran interaktif untuk materi skrining fitokimia pada mata kuliah Praktikum Fitokimia di Jurusan Analisis Farmasi dan Makanan Poltekkes Kemenkes Jakarta II. akan diterapkan pada smartphone berbasis iOS dan dirancang untuk pembelajaran fitokimia di laboratorium. Metode yang digunakan dalam penelitian ini adalah deskriptif eksploratif untuk analisis fitokimia dan Multi-Media Development Life Cycled (MDLC) untuk pengembangan AR. Hasil skrining fitokimia beberapa serbuk simplisia dijadikan sebagai objek 3D menggunakan aplikasi Blender, dengan Unity sebagai <em>game engine</em> dan Vuforia sebagai <em>library</em>. Pengembangan teknologi AR menghasilkan aplikasi mobile berbasis iOS dengan nama AR Fitokimia yang memvisualisasikan hasil skrining fitokimia. Aplikasi ini akan membantu meningkatkan pemahaman dan partisipasi siswa dalam pembelajaran jarak jauh. Aplikasi pembelajaran mobile AR interaktif untuk smartphone berbasis iOS dapat dirancang untuk seluruh kelas dengan perangkat i-Family dalam mengatasi pembelajaran jarak jauh skrining fitokimia di laboratorium.
PENGEMBANGAN OPEN ENDED PLAY UNTUK MENINGKATKAN KOMPETENSI ABAD 21 (4CS) PADA ANAK USIA 4-6 TAHUN
Authors: Sutama I Wayan , Astuti Wuri , Pramono Pramono , Nur'Aini Dewi Endah , Sangadah Lailatus 
Published: September 2022

Abstrak: Tujuan pelatihan ini adalah meningkatkan pemahaman dan keterampilan guru dalam mengembangkan open ended play untuk meningkatkan kompetensi abad 21 pada anak usia 4-6 tahun. Fakta menunjukkan bahwa pembelajaran yang dilakukan oleh guru mengarah pada capaian perkembangan lower order thinking skills sehingga kurang mendukung tercapainya kompetensi tersebut. Metode yang digunakan meliputi pendalaman materi, workshop, peer review, uji coba lapangan dan finalisasi permainan. Hasil pelatihan menunjukkan tingkat partisipasi, keaktivan dan kemampuan mengembangkan open ended play tergolong sangat tinggi. Hal ini dapat dicapai karena sebagian besar peserta menganggap kegiatan ini sangat sesuai, menarik dan menantang untuk diimplementasikan dalam pembelajaran. Abstract: The purpose of this training is to improve the understanding and skills of teachers in developing open ended play to improve 21st century competence in children aged 4-6 years. The facts show that the learning carried out by the teacher leads to the achievement of the lower order thinking skills development so that it does not support the achievement of these competencies. The methods used include deepening the material, workshops, peer reviews, field trials and finalization of the game. The results of the training show that the level of participation, activity and ability to develop open ended play is very high. This was achieved because most of the participants considered this activity very appropriate, interesting and challenging to implement in learning.
​Performance of Pigeon Pea [Cajanus cajan (L.) Millsp] Genotypes under Cold Stress
Authors: Tiwari T.N. , Dutta D. , Tewari Kalpana 
Published: September 2022

Background: In north India, pigeon pea experiences low temperature stress during winter months (December-January). Information’s regarding cold stress and its impact on morphological characters, physio-biochemical processes and yield attributes in pigeon pea crop is very limited. Keeping the above facts in to consideration, the experiment was formulated to screen suitable genotypes of pigeon pea tolerant to cold stress based on morpho-physiological traits and ability to set flower and pods and yield performance. Methods: Field experiments with 98 genotypes of pigeon pea were conducted in augmented design including checks with all recommended cultural practices in 2018-19 and 2019-20 at New Research Farm, ICAR-IIPR, Kanpur. Morphological, biochemical and yield parameters were recoded periodically. Result: Based on the reaction of pigeon pea genotypes against the exposer of cold stress in terms of flower/pod drop and flower/pod retention, cold injury at the apical meristems and post regeneration of apical portion, the genotypes like IPA 15F, Dhule-D, JBT46/27, IPACT-6, IPACT-14, IPAC-1-17, IPACT-68, IPACT-22 showed greater than 90% flower/pod drop and retained only 0-10% flowers/pods, greater than 90% apical damage and less than 10% recovery of apical portion and were considered highly sensitive to cold stress. Genotypes namely MA-3, IPA 9F, ICP 15-9-1, VKG 27/161, H-26, ICPL 7035, LRG-30, PBT/SSL 2/73, KPL 1034-31, IPA 15-15, KPL 34, ICP 2073, IPACT-5, IPAB 10-66, IPACT-10, IPACT-11, IPAHT-26, IPACT-15, IPAD 2-8, IPACT-16, IPAD-8, IPACT-17, IPAHT-43, IPACT-21 showed greater than 80% flower/pod drop and retained 10-20% flower/pods, greater than 80%apical damage and less than 20% recovery of apical portion and considered moderately susceptible to cold stress. Genotypes NDA-2, MAL-13, ICP-2275, IPACT-2 showed around 20-40% flower/pod drop and have retained 60-80% flowers/pods, less than 20% apical damage and greater than 80% recovery of apical portion were considered as the highly tolerant to cold stress. The nitrogen balance index, chlorophyll and flavonols showed higher values in tolerant group whereas lower in susceptible group. The average yield/plant of pigeon pea genotypes tolerant to cold stress is considerably higher than the susceptible group of pigeon pea genotypes.
EKSTRAKSI DAN UJI POTENSI ANTIOKSIDAN DARI SENYAWA POLIFENOL JANTUNG PISANG CAVENDIS (Cavendis varadishii) YANG DIFERMENTASI ASAL PT. NUSANTARA TROPICAL FARM (NTF) LAMPUNG
Authors: Kurniawati N. , Khasbullah F. , Priyadi Priyadi 
Published: September 2022

Banana blossom is waste, especially in PT. Nutrition Tropical Farm (NTF) as the largest bananaexporter in Lampung. Cavendis banana blossom in PT. NTF cannot be consumed like some other particular banana blossoms. Cavendis banana blossom from the company has a bitter tastebecause it contains high polyphenol compounds. High polyphenol compounds in the banana blossom can be acquired through an extraction process that furthermore can be used as antioxidants. By utilizing the polyphenol compounds in the banana blossom, it is possible to utilize and optimize the use value and economic value of the waste or by products of banana plant cultivation. The purposes of this study are 1) Increasing the acquisition of polyphenol extracts in Cavendis banana blossom extract from PT. NTF, 2) antioxidant activity by polyphenol compounds extract of Cavendis banana blossom from PT. Nusantara Tropical Farm. The result shows that spontaneous fermentation of the banana blossom affects the lignocellulose component and the acquisition of bioactive compounds. The highest yield of bioactive components extracts produced from 3 th day incubation for total polyphenols (982 mg/100mg), anthocyanin (25.34 mg/100 mg) and the highest antioxidant activity of catechin (37.74%) produced form 3 th day incubation.
HUBUNGAN TEKNIS AGRONOMI PELIBURAN TANAMAN JERUK SIAM BANJAR (Citrus reticulata) DENGAN WAKTU PEMATANGAN BUAH BERDASARKAN TIPE LUAPAN DI KABUPATEN BARITO KUALA
Authors: Dewi Karina Citra , Rusmayadi Gusti , Adriani Dewi Erika 
Published: September 2022

Peliburan is a term, that raised up the mud from the channels to the mound (called tukungan/guludan in local language) or raise beds as one of agronomic technics based on local indigenous of tidal swamplands farmers in South Kalimantan. Peliburan has many benefits for Siam Banjar citrus plant, namely creating a suitable microclimate so that it might be used to determine the appropriate time for ripening and harvesting of citrus fruits. The objectives of this study were to: 1) Determine the effect of peliburan on ripening time of Siam Banjar citrus fruit based on the type of overflow in Barito Kuala Regency, 2) Determine the joint or simultaneous effect, and partial effect of peliburan on ripening time of the Siam Banjar citrus fruit in Barito Kuala Regency 3) Determine the direct effect of peliburan on ripening time of Siam Banjar citrus fruit in Barito Kuala Regency. The recent study used survey and observation methods. The research location was chosen in purposive sampling method by considering the type of overflow and farmers as respondents in the selected villages with high productivity of Siam Banjar citrus. The study was conducted in four district in Barito Kuala Regency, namely Mandastana District, Belawang District, Cerbon District and Barambai District. The data analysis used to determine the effect of Peliburan was multiple regression analysis with a dummy variable consisted of 7 variables, namely X1 : time of peliburan, X2 : shape of peliburan, X3 : diameter of peliburan (cm), X4 : height of peliburan (cm), X5 : spacing between peliburan (population), X6 : age of peliburan (years) and X7 : Soil temperature (oC). The results showed that agronomic technics that is shape of peliburan, height of peliburan, spacing between peliburan and soil temperature had an effect on ripening time of Siam Banjar citrus fruit both at type A and type B overflow in Barito Kuala Regency. Simultaneously, all independent variables of peliburan had a significant linear relationship with the dependent variable that is ripening time of Siam Banjar citrus fruit in Barito Kuala Regency. Partially, at type A overflow, time of peliburan, diameter of peliburan, spacing between peliburan , height of peliburan, and soil temperature had a significant effect, whereas at type B overflow, time of peliburan, diameter of peliburan, height of peliburan, spacing between peliburan and age of peliburan had a significant effect on ripening time of Siam Banjar citrus fruit. The dominant direct effect of peliburan at type A and type B overflow was the soil temperature and height of peliburan.
DAMPAK LINGKUNGAN PEMBANGUNAN PABRIK FARMASI XYZ DI JAWA TENGAH
Authors: Yusuf Muhamad 
Published: September 2022

The construction of a pharmaceutical factory has an impact in the form of a decline in the surrounding environment. This study aims to determine the environmental impact arising from construction a pharmaceutical factory. A descriptive qualitative approach was used. Analyses show that the development meets the environmental baseline in terms of the geo-physical aspect, but for the water around the location for several parameters it is above the quality standard, in terms of the biological environmental baseline it meets as a project development area, and In terms of the socio-economic and cultural components of the community. Some of the components that influence and cause a decline in development include: Physical and Chemical Environment, community social environment, environmental health. To overcome the problems that arise, recommendations are given for the water that will be used for factory operations by making a storage pond to accommodate rainwater and treated water from the WWTP so that it can be processed into clean water in the RWTP unit and management is carried out on all components of activities that have an impact. As a result, the pharmaceutical factory can be constructed according to plan.
Coaching, Separate from Mentoring, May Provide Skill Acquisition, Improved Well-Being, and Career Advancement in Orthopaedic Surgery
Authors: Samora Julie Balch , Brown Gregory A. , Clohisy Denis , Weber Kristy 
Published: September 2022

Abstract:
Coaching is separate from mentoring, and can include life coaching, skills coaching, and behavior coaching. Life coaching can focus on purpose, work-life balance, well-being, and career path. Skills coaching encourages mastery and promotes autonomy. Behavior coaching may be mandated for a disruptive surgeon. Coaching has been shown to reduce burnout and promote well-being and can potentially advance a surgeon’s career trajectory and leadership skills.
Adjuvant trastuzumab without chemotherapy for treating early HER2-positive breast cancer in older patients: a propensity score-adjusted analysis of a prospective cohort study
Authors: Sawaki Masataka , Taira Naruto , Uemura Yukari , Saito Tsuyoshi , Baba Shinichi , Kobayashi Kokoro , Kawashima Hiroaki , Tsuneizumi Michiko , Sagawa Noriko , Bando Hiroko , Takahashi Masato , Yamaguchi Miki , Takashima Tsutomu , Nakayama Takahiro , Kashiwaba Masahiro , Mizuno Toshiro , Yamamoto Yutaka , Iwata Hiroji , Toyama Tatsuya , Tsugawa Koichiro , Kawahara Takuya , Mukai Hirofumi 
Published: September 2022

Abstract

Purpose To gauge the effects of treatment practices on prognosis for all older patients with HER2-positive early breast cancer, particularly to determine whether adjuvant trastuzumab alone can offer benefit over no adjuvant therapy. This report accompanies the RESPECT study, a randomized-controlled trial (RCT) comparing trastuzumab monotherapy with trastuzumab-plus-chemotherapy.Patients and methods Patients who declined the RCT were treated based on the physician’s discretion. We studied the (1) trastuzumab-plus-chemotherapy group, (2) trastuzumab-monotherapy group, and (3) non-trastuzumab group (no therapy or anticancer therapy without trastuzumab). The primary endpoint was disease-free survival (DFS), which was compared using the propensity-score method. Relapse-free survival (RFS) and health-related quality of life (HRQoL) were also assessed.Results We enrolled 123 eligible patients, aged over 70 years, with HER2-positive invasive breast cancer in this cohort study. The median age was 74.5 years. Among cohort study treatment categories were as follows: (1) trastuzumab-plus-chemotherapy group (n = 36, 30%), (2) trastuzumab-monotherapy group (n = 52, 43%), and (3) non-trastuzumab group (n = 32, 27%). A total of 73% of patients received trastuzumab-containing regimens, with or without chemotherapy. The 3-year DFS was 92.3% in the trastuzumab-plus-chemotherapy group, 89.2% in the trastuzumab-monotherapy group, and 82.5% in the non-trastuzumab group. DFS in the non-trastuzumab group was lower than in the trastuzumab-plus-chemotherapy and trastuzumab-monotherapy groups (propensity-adjusted HR: 3.29; 95% CI: 1.15–9.39; P = 0.026). The RFS in the non-trastuzumab group was lower than in the trastuzumab-plus-chemotherapy and trastuzumab monotherapy groups (propensity-adjusted HR = 7.80; 95% CI: 2.32–26.2, P < 0.0001). There were no significant intergroup differences in the proportions of patients showing QoL deterioration (P = 0.717) and improvement (P = 0.652) at 36 months.Conclusions Trastuzumab-treated patients had better prognoses than patients not treated with trastuzumab without deterioration of HRQoL. Thus, trastuzumab monotherapy can be considered for patients who reject chemotherapy.Trial registration number The protocol was registered on the website of the University Hospital Medical Information Network (UMIN), Japan (protocol ID: UMIN 000028476).
The Whistleblower’s Dilemma: An Evolutionary Game Analysis of the Public Health Early Warning System
Authors: Cao Feng , Zhang Ling , Wu Yihan 
Published: September 2022

Abstract

Although the ability to manage public health emergencies in China has improved significantly, there are still many challenges to the existing information transmission mechanism in pandemic early warning systems. In this context, a tripartite evolutionary game model composed of the local government, the whistleblower, and the public is formulated. By using Matlab, the dynamic evolution path of the game model is stimulated under different conditions. Stable strategies for an early warning system for public health emergencies are also being explored. The results indicate that the cost of whistleblowing, the cost of response, and the benefit of attention significantly influence strategic decisions among three parties. This study highlights the importance of whistleblowing in managing public health emergencies. Yet our findings provide theoretical support for policy recommendations for promoting public health emergency preparedness.
Prevalence, trend and associated risk factors of Mother-to-Child Transmission of HIV among HIV-exposed infants
Authors: Gutema Gadissa , Hailu Habteyes , Fikadu Dinka , Leta Dereje , Bejiga Birra , Bulti Jaleta , Abdela Saro , Mamo Hassen 
Published: September 2022

Abstract
Background
The Human Immunodeficiency Virus (HIV) Mother-To-Child-Transmission (MTCT) can primarily occur during pregnancy, birth and breastfeeding. However, there is limited recent evidence from large-scale study on MTCT of HIV in Ethiopia. Thus, this study was aimed to determine the prevalence, trend and associated risk factors of MTCT among HIV-exposed infants.
Methodology
: A cross-sectional study was conducted on 5,679 infants whose specimen referred to Ethiopian Public Health Institute HIV referral laboratory from January 01, 2016 to December 31, 2020. Required information was obtained from Early Infant Diagnosis (EID) database. Frequencies and percent were used to describe the distribution of the infants. Logistic regression analysis was used to identify factors associated with HIV infection. The level of significance was set at 5%.
Results
The mean age of the infants was 12.64 (± 14.62) weeks with 4 to 72 weeks range. Half of the infants (51.4%) were female. Prevalence of HIV infection over the course of five years among HIV-exposed infants (HEI) was 2.6%. The prevalence of MTCT decreased from 2.9% in 2016 to 0.9% in 2020. After adjusting for covariates; infant testing after six weeks (Adjusted odds ratio (AOR) = 2.7; 95% confidence interval (CI): (1.8–4.0, )) p-value < 0.001, absence of Prevention of Mother-To-Child-Transmission (PMTCT) service (AOR = 4.6; 95% CI: (2.9–7.4)) p-values = 0.001, lack of obtaining nevirapine prophylaxis (AOR = 2.0; 95% CI: (1.3–3.2)) p-value < 0.001, and mother HIV status before date of delivery (AOR = 11; 95% CI: (5.5–22.1)) p-value < 0.001 were significantly associated with MTCT of HIV.
Conclusion
The prevalence of MTCT of HIV is considerable. However, the prevalence was declining during the study period. Tested after six weeks for EID, unavailability of PMTCT service were the factors associated with HIV infection among HEI. Strengthen PMTCT service and early HIV screening of pregnant women are critical to reduce HIV infection among HEI.
α-Synuclein oligomers induce the loss of dopaminergic neurons via mitochondrial dysfunction and oxidative stress in an intragastric rotenone mouse model of Parkinson’s disease
Authors: Huang Teng , Chen Juan , Hong Mei , Huang Mengyang , Jiang Hong , Zhou Honglian , Zhu Suiqiang , Hu Qi 
Published: September 2022

Abstract
Background
α-Synuclein (α-Syn) oligomers play a critical role in the pathogenesis of Parkinson's disease (PD). Neuronal death induced by α-Syn oligomers is thought to be associated with mitochondrial dysfunction and oxidative stress. This study investigated the effect of α-Synuclein oligomers on mitochondrial dysfunction and oxidative stress in an intragastric rotenone mouse model of Parkinson’s disease and the human dopaminergic neuroblastoma (SH-SY5Y) cells.
Methods
A chronic PD mouse model was established by daily intragastric administration of rotenone (5 mg/kg, 12 weeks). α-Syn aggregation in midbrain was detected by western blot and immunofluorescence. Oxidative stress levels and mitochondrial morphology in neurons of the substantia nigra in these mice were tested by levels of malondialdehyde (MDA), super oxide dismutase (SOD), and glutathione peroxidase (GSH-Px) and transmission electron microscopy (TEM). The above results were validated in vitro by lentiviral overexpression and RNAi silencing of α-Syn expression in SH-SY5Y cells.
Results
α-Syn oligomers were accumulated in the midbrain of wild-type mice and the number of dopaminergic neurons was significantly reduced in the rotenone-treated mice. These mice also exhibited increased reactive oxygen species levels and morphological alterations of mitochondria in the midbrain. These results were reproduced in the α-Syn-transfected SH-SY5Y cells.
Conclusion
α-Syn oligomers induce neuronal death via mitochondrial dysfunction and oxidative stress.