bluuebunny/crossref_metadata_2025_split huggingface dataset:
Load–Velocity Relationship to Estimate the One-Repetition Maximum in the Hexagonal Bar Deadlift Exercise in Women
Authors: Gantois Petrus , Gilo Drumond , Denise Ana , Muñoz-López Alejandro , Nakamura Fábio Yuzo , de Souza Fonseca Fabiano 
Published: September 2022

In this study, we examined the load–velocity relationship in the hexagonal bar deadlift exercise in women. Twenty-seven resistance-trained women were recruited. Participants performed a progressive load test up to the one-repetition maximum (1RM) load for determining the individual load–velocity relationship in the hexagonal bar deadlift exercise. Bar velocity was measured in every repetition through a linear encoder. A very strong and negative relationship was found between the %1RM and bar velocity for the linear (R2 = .94; standard error of the estimation = 5.43% 1RM) and second-order polynomial (R2 = .95) regression models. The individual load–velocity relationship provided even better adjustments (R2 = .98; coefficient of variation = 1.77%) than the general equation. High agreement level and low bias were found between actual and predicted 1RM for the general load–velocity relationship (intraclass correlation coefficient = .97 and 95% confidence interval [0.90, 0.99]; bias = −2.59 kg). In conclusion, bar velocity can be used to predict 1RM with high accuracy during hexagonal bar deadlift exercise in resistance-trained women.
The age limit for euthanasia requests in the Netherlands: a Delphi study among paediatric experts
Authors: de Keijzer Sedona Celine , Widdershoven Guy , Verhagen A A Eduard , Pasman H Roeline 
Published: September 2022

BackgroundThe Dutch Euthanasia Act applies to patients 12 years and older, which makes euthanasia for minors younger than 12 legally impossible. The issue under discussion specifically regards the capacity of minors to request euthanasia.ObjectiveGain insight in paediatric experts’ views about which criteria are important to assess capacity, from what age minors can meet those criteria, what an assessment procedure should look like and what role parents should have.MethodsA Delphi study with 16 experts (paediatricians, paediatric nurses and paediatric psychologists) who work in Children Comfort Teams in Dutch academic hospitals. The questionnaire contained statements concerning criteria for capacity and procedural criteria. Consensus was defined as ≥80% agreement.ResultsThe experts agreed that five criteria for capacity, found in a previous literature study, are all important. They agreed that some children between ages 9 and 11 could meet all the criteria. Consensus was reached for the statements that the entire medical team should be involved in the decision making and that a second independent expert must assess the case. Experts agreed that the parents’ opinion is relevant and should always be taken into account, but it need not be decisive.ConclusionThis study shows that the age limit of 12 years in the Dutch Euthanasia Act is too strong according to paediatric experts. Letting go of the age limit or lowering the age limit combined with adequate capacity assessment for minors younger than 12 are options that should be discussed further.
On the equivalence of two definitions of conformal primary fields in d > 2 dimensions
Authors: Campos Delgado Ruben 
Published: September 2022

AbstractConformal primary fields are of central importance in a conformal field theory with d > 2 spacetime dimensions. They can be defined in two ways. A first definition involves commutators between the field and the generators of the conformal group; a second definition characterizes a primary field according to its behaviour under a finite conformal transformation. In the existing literature, the proof of the equivalence of the definitions is either omitted or carried out with little details. In this paper we present a clear and concise review of the two definitions and provide a simple and detailed proof for their equivalence, using some minimal results from quantum field theory and basic properties of conformal transformations. The paper is intended as a tutorial for an introductory lecture course in conformal field theory.
SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in De Novo Metastatic Castration-Sensitive Prostate Cancer
Authors: Swami Umang , Graf Ryon P. , Nussenzveig Roberto H. , Fisher Virginia , Tukachinsky Hanna , Schrock Alexa B. , Li Gerald , Ross Jeffrey S. , Sayegh Nicolas , Tripathi Nishita , Mathew Thomas Vinay , Oxnard Geoffrey R. , Antonarakis Emmanuel S. , Agarwal Neeraj 
Published: September 2022

Abstract

Purpose:
Intensification of androgen deprivation therapy (ADT) with either docetaxel or androgen receptor axis–targeted therapies (ARAT) are the current standard of care for patients with metastatic castration-sensitive prostate cancer (mCSPC). However, biomarkers guiding treatment selection are lacking. We hypothesized that ADT intensification with ARAT, but not with docetaxel, would be associated with improved outcomes in patients with de novo (dn)-mCSPC harboring SPOP mutations.

Experimental Design:
Patient-level data from a deidentified nationwide (U.S.-based) prostate cancer clinico-genomic database between January 2011 and December 2021 were extracted. Eligibility criteria: diagnosis of metastatic disease within 30 days of original prostate cancer diagnosis, genomic profiling of a tissue biopsy collected within 90 days of original diagnosis, and initiation of ARAT or docetaxel within 120 days of initial diagnosis. The log-rank test and Cox proportional hazards models were used to compare time to castration-resistant prostate cancer (TTCRPC) and overall survival (OS) for patients with and without SPOP mutations undergoing ADT intensification with ARAT or docetaxel.

Results:
In the ARAT cohort, presence of SPOP mutation compared with wild-type was associated with more favorable TTCRPC [not reached (NR) vs. 16.7 months; adjusted HR (aHR), 0.20; 95% confidence interval (CI), 0.06–0.63; P = 0.006] and OS (NR vs. 27.2 months; aHR, 0.19; 95% CI, 0.05–0.79; P = 0.022). In contrast, SPOP mutation status was not associated with TTCRPC or OS in docetaxel-treated cohort.

Conclusions:
In real-world settings, SPOP mutations were associated with improved outcomes to ADT plus ARAT (but not ADT plus docetaxel) in patients with dn-mCSPC. This may serve as a predictive biomarker to guide treatment selection for patients with mCSPC.
Abstract IA015: ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops
Authors: Jones Kevin B. 
Published: September 2022

Abstract
Aberrant transcription in alveolar soft part sarcoma and some Xp11-rearranged renal cell carcinomas is orchestrated by the fusion oncoprotein, ASPSCR1-TFE3, expressed from a t(X;17) chromosomal translocation-mediated fusion gene. Here, proteomic analysis of proteins co-immunoprecipitated with ASPSCR1-TFE3 from human cell lines and mouse genetically-induced tumors revealed strong enrichment of a AAA+ ATPase with known segregase function. Native gel and electron microscopy found that ASPSCR1-TFE3 associates multi-valently with segregase hexamers. Forward and reverse genetic experiments with ASPSCR1-TFE3 and the segregase demonstrated that they function co-dependently for cancer cell proliferation. The presence, hexamer assembly, and enzymatic function of the segregase enabled the transcriptional impact of ASPSCR1-TFE3. The two proteins co-distributed across chromatin genome-wide, associated with enhancers, indicated by flanking H3K27ac enrichment in human cell lines, human tumors, and genetically engineered mouse tumors. These assembled into higher-order chromatin conformation structures demonstrated by HiChIP and downregulated by loss of ASPSCR1-TFE3 or the segregase. Thus, a segregase was found to assemble chromatin into three-dimensional structures as a co-factor of oncogenic transcriptional regulation.
Citation Format: Kevin B. Jones. ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops [abstract]. In: Proceedings of the AACR Special Conference: Sarcomas; 2022 May 9-12; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2022;28(18_Suppl):Abstract nr IA015.
Aphids, sex, chromosomes and molecular biology (Hemiptera: Aphidoidea)
Authors: HALES DINAH 
Published: September 2022

In this paper, I summarise work at Macquarie University on aphid diversity in Australia, chromosome numbers, and chromosome behaviour during spermatogenesis and during sex determination in the aphid embryo. Much of this was inspired by Dr Roger Blackman, and some was done in direct collaboration with him. During the 1990s, the Macquarie group developed molecular techniques to investigate aphid population genetics and major questions such as the evolution of sex. These experiments built on the earlier work on aphid karyotypic races and the cytology of egg maturation and spermatogenesis. "From little things, big things grow".1

1 Title of song by Paul Kelly and Kev Carmody, first recorded in 1991.
Immigration of Medical Workers and Variable Labour Supply
Authors: Okawa Masayuki 
Published: September 2022

This paper studies the effects of immigration policy on the immigration of foreign medical workers on the welfare and income distribution of home medical workers and labourers. We set up a simple small open economy with two traded goods and non-traded medical care services. In the economy, there exists a constant rate of labourers who get ill health and must leave their jobs and thereby lose part of their income. But they can reduce the loss of working time and income by consuming medical services. There are two channels that consumption of the medical service affects the welfare of consumers: (i) consumption of medical service raises the state of health and increases utility, and (ii) consumption of medical service reduces the leave period of labourers and raises their wage income (labour supply-enhancing effect). We see that the above second effect makes the effective price of the medical service for the consumer lower than its market price and causes consumption bias towards the consumption of medical services. To introduce the above properties of consumption of medical service, we define the effective expenditure function of the labourers and examine its properties and conduct comparative static analyses. JEL codes: F13, F22
Temporal changes in the Swiss flora: implications for flower-visiting insects
Authors: Abrahamczyk Stefan , Kessler Michael , Roth Tobias , Heer Nico 
Published: September 2022

Abstract
Background
Local floristic diversity has massively decreased during the twentieth century in Central Europe even though in the 1990s diversity began increasing again in several regions. However, little is known whether this increase is equally distributed among plant groups with different reproductive traits.

Methods
Our study is based on data of the Swiss Biodiversity Monitoring Program. In this program, plant species occurrence is recorded since 2001 in 450 regularly distributed 1 km2 study sites. For all 1774 plant species registered in the study, we researched data on flower/pseudanthium type and colour, reproductive system, and groups of flower visitors. We then tested whether temporal changes in species frequency were equally distributed among species with different trait states.

Results
Species richness and functional richness significantly increased in the study sites while functional evenness decreased. The frequency of wind-pollinated species increased more strongly than that of insect-pollinated species. Further, the frequency of species with simple, open insect-pollinated flowers and pseudanthia visited by generalist groups of insects increased slightly more strongly than the frequency of species with complex flowers visited by more specialized groups of flower visitors. Additionally, the frequency of self-compatible species increased significantly more than that of self-incompatible species. Thus, the overall increase in local plant species richness in Switzerland is mostly driven by wind- and generalist insect-pollinated, self-compatible species. In contrast, species with complex flowers, which are essential for specialized groups of flower visitors and species with self-incompatible reproductive systems profited less.

Conclusions
Our study thus emphasizes the need to consider functional traits in the planning and monitoring of conservation activities, and calls for a special focus on plant species with specialized reproductive traits.
Post-operative uric acid: a predictor for 30-days mortality of acute type A aortic dissection repair
Authors: Ma Shulun , Xu Qian , Hu Qinghua , Huang Lingjin , Wu Dongkai , Lin Guoqiang , Chen Xuliang , Luo Wanjun 
Published: September 2022

Abstract
Background
Hyperuricemia is associated with aortic dissection and cardiovascular diseases. The implication of high serum uric acid (UA) level after acute aortic dissection repair remains unknown. The aim of this study is to explore the role of peri-operative serum UA level in predicting 30-days mortality with acute type A aortic dissection (AAAD) patients, who underwent surgery.

Methods
This study retrospectively enrolled 209 consecutive patients with AAAD, who underwent surgery in Xiangya Hospital from 2017 to 2020. Post-operative laboratory examinations were measured within 24 h after surgery. Univariate analysis and logistic regression analysis were used for predictor finding.

Results
209 consecutive AAAD patients were included, 14.3% (n = 30) were dead within 30 days after surgery. By univariate analysis, we found AAAD repair patients with 30-days mortality had a higher prevalence of cerebral malperfusion, lower pre-operative fibrinogen, longer cardiopulmonary bypass and aortic crossclamp time, and higher post-operative day 1 (POD1) creatinine and urea levels. Both pre-operative (433.80 ± 152.59 vs. 373.46 ± 108.31 mmol/L, p = 0.038) and POD1 (559.78 ± 162.23 vs. 391.29 ± 145.19 mmol/L, p < 0.001) UA level were higher in mortality group than in survival group. In regression model, only cerebral malperfusion (OR, 7.938, 95% CI 1.252–50.323; p = 0.028) and POD1 UA level (OR, 2.562; 95% CI 1.635–4.014; p < 0.001) were independent predictors of 30-days mortality in AAAD repair patients. According to the ROC curve, the POD1 UA level provided positive value for 30-days mortality in AAAD repair patients with 0.799 areas under the curve. The optimum cutoff value selected by ROC curve was 500.15 mmol/L, with a sensitivity of 65% and a specificity of 86%.

Conclusion
Pre- and post-operative hyperuricemia are potentially associated with worsened outcomes in AAAD surgery patients. The POD1 UA level has a predictive role in 30-days mortality in AAAD repair patients.
Dynamic regulation of HIF-1 signaling in the rhesus monkey heart after ischemic injury
Authors: Wang Tao , Xiao Ying , Zhang Jingyao , Jing Fujia , Zeng Guodan 
Published: September 2022

Abstract
Background
Hypoxia inducible factor-1 (HIF-1) plays a key role in modulating post-infarct healing after myocardial ischemic injury through transcriptional regulation of hundreds of genes involved in diverse cardiac remodeling processes. However, the dynamic changes in HIF-1 target gene expression in the ischemic heart after myocardial infarction (MI) have not been well characterized.

Methods
We employed a rhesus monkey model of MI induced by left anterior descending artery ligation and examined the expression pattern of HIF-1 target genes in the ischemic heart at 1, 7, and 28 days after injury by bulk RNA-sequencing analysis.

Results
Myocardial transcriptomic analysis demonstrated a temporal-specific regulation of genes associated with the inflammatory response, cell proliferation, fibrosis and mitochondrial metabolism during the pathological progression of MI. HIF-1 target genes involved in processes related to glycolysis, angiogenesis, and extracellular matrix (ECM) remodeling also exhibited distinct expression patterns during MI progression. Copper concentrations were gradually decreased in the heart after ischemic injury, which was positively correlated with the expression of HIF-1-mediated angiogenic and glycolytic genes but negatively correlated with the expression of HIF-1-mediated ECM remodeling genes. Moreover, genes related to intracellular copper trafficking and storage were suppressed along with the loss of myocardial copper in the ischemic heart.

Conclusions
This study demonstrated a dynamic, functional-specific regulation of HIF-1 target gene expression during the progression of MI. The fine-tuning of HIF-1 signaling in the ischemic heart may be relate to the alteration in myocardial copper homeostasis. These findings provide transcriptomic insights into the distinct roles of HIF-1 signaling in the heart after ischemic injury, which will help determine the beneficial cutoff point for HIF-1 targeted therapy in ischemic heart diseases.
Clinical characteristic and pathogenesis of tumor-induced acute pancreatitis: a predictive model
Authors: Zheng Linlin , Zhao Ping , Peng Xiaoqian , Zhou Yunhui , Bao Yichen , Sun Yuling , Zhou Lin 
Published: September 2022

Abstract
Background
The aim of our study was to investigate the clinical characteristics and pathogenesis of tumor-induced acute pancreatitis (AP), and to develop a reliable prediction model of the clinical features to guide the diagnosis and treatment.

Methods
Patients with AP between January 2013 and December 2021 were enrolled in the study and were subdivided into the tumor group and the non-tumor group. The tumor group was subdivided into three groups based on the primary sites. Characteristic parameters, laboratory and imaging results were compared between groups. Least absolute shrinkage and selection operator regression model, XGBoost and random forest model were used to select the predictors associated with tumor-induced AP. Logistic regression analysis was used to validate the performance of the selected predictors and a nomogram was established to provide individualized probability of a tumor origin for AP.

Results
A total amount of 8970 patients were admitted for AP during the study period, and 8637 AP patients were enrolled in the study. Of these, 100 cases (1.16%) were tumor-induced AP. The tumor group was significantly older than the non-tumor group (t = 6.050, p = 0.000). Mild AP was observed in 90 cases, moderate AP in 9 cases and severe AP in one case. Tumors respectively originated from distal bile duct (14 cases), ampulla (13 cases) and pancreas (73 cases). The median time from initial AP to tumor diagnosis was 8.57 weeks and the median number of episode was 2 in the tumor group, which significantly surpassed the non-tumor group (p = 0.000). Age, white blood cell count, percentage of neutrophils, pancreatic or bile duct dilation and recurrent attacks were selected independent predictors for tumor origin. A nomogram model based on these factors was established.

Conclusion
For patients with agnogenic AP, elderly man, recurrent attacks, pancreatic or bile duct dilatation and continuous no significant increase of inflammatory markers prompt to further screening of pancreatic biliary and ampulla.
The psychosocial health, experiences and needs of older adults and care partners during the first surge of the COVID-19 pandemic: a mixed-methods study
Authors: Marziliano Allison , Burns Edith , Pampanini Taline , Tom Jennifer , Ardito Suzanne , Ilyas Anum , Carney Maria T. , Diefenbach Michael A. , Makhnevich Alex , Sinvani Liron 
Published: September 2022

Abstract
Background
Minimal research has leveraged qualitative data methods to gain a better understanding of the experiences and needs of older adults (OAs) and care partners of OAs with and without Alzheimer’s Disease (AD) and AD-related dementias (AD/ADRD) during the first surge of the COVID-19 pandemic. In this study, we: 1) quantitatively evaluated the psychosocial health of community-dwelling OAs; 2) quantitatively evaluated the perceived stress of care partners for OAs; 3) qualitatively characterized the experiences and needs of community-dwelling OAs and their care partners; and 4) explored differences in the experiences of care partners of OAs with and without AD/ADRD during the first surge of the COVID-19 pandemic in the New York metropolitan area.

Methods
In this mixed-methods study, telephone interviews were conducted with 26 OAs and 29 care partners (16 of whom cared for OAs with AD/ADRD) from April to July 2020. Quantitative data included: demographics; clinical characteristics (Katz Index of independence in activities of daily living (Katz ADL) and the Lawton-Brody instrumental activities of daily living scale (Lawton-Brody)); and psychosocial health: stress was assessed via the Perceived Stress Scale (PSS), social isolation via the Lubben Social Network Scale (LSNS), loneliness via the DeJong Loneliness Scale (DeJong), and depression and anxiety via the Patient Health Questionnaire-Anxiety and Depression (PHQ). Qualitative questions focused on uncovering the experiences and needs of OAs and their care partners.

Results
OAs (N = 26) were mostly female (57.7%), and White (76.9%), average age of 81.42 years. While OAs were independent (M = 5.60, Katz ADL) and highly functional (M = 6.92, Lawton-Brody), and expressed low levels of loneliness, stress, depression and anxiety (M = 1.95 on DeJong; M = 12.67 on PSS; M = 1.05 on PHQ depression; and M = 1.09 on PHQ anxiety), open-ended questions elicited themes of fear and worry. Care partners (N = 29) were mostly female (75.9%), White (72.4%), and married (72.4%), and reported moderate stress (M = 16.52 on the PSS), as well as a psychological impact of the pandemic.

Conclusions
Early in the pandemic, OAs reported minimal stress and loneliness; this may have been related to their reports of frequent interaction with family, even if only virtually. By contrast, care partners were moderately stressed and worried, potentially more than usual due to the additional challenges they face when trying to meet their loved ones’ needs during a pandemic.