bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children: Serious Illness
Authors: Rafferty Katherine A. , Lipovac Melissa , Nemmers‐Bello Stephanie , Magsamen‐Conrad Kate 
Published: September 2022

Abstract
Communication is vital to the management of serious illness in children. While the definition of serious illness in pediatrics is not yet agreed upon, these different acute, chronic, complex, and sometimes life‐limiting or life‐threatening illnesses present many communication challenges and barriers. These challenges are particularly evident for parents and legal guardians who are often charged with the responsibilities of managing their child's care and coordinating it with various healthcare clinicians. New caregiving responsibilities for parents create a host of uncertainties for them and their child that require a collaborative discussion with their child's healthcare team. The involvement of a pediatric palliative care team can facilitate successful collaborations that promote shared decision making, empower the sick child and his or her family, and facilitate difficult conversations weighing the risks and benefits of medical interventions, including but not limited to care in emergency medical situations – as may be outlined in an advance care planning document. Noting the complexity of the health information, it is of utmost importance that clinicians take into consideration the families' health literacy, culture, and language in order to ensure clear, transparent, and supportive communication.
Predictors of survival outcomes among patients with gastric cancer in a leading tertiary, teaching and referral hospital in Kenya
Authors: Degu Amsalu , Karimi Peter N. , Opanga Sylvia A. , Nyamu David G. 
Published: September 2022

AbstractIntroductionThe incidence of gastrointestinal malignancies in Kenya is increasing, although there is a paucity of data on survival outcomes among gastric cancer patients. Hence, this study aimed to assess survival outcomes among adult gastric cancer patients at Kenyatta National Hospital.MethodsA retrospective cohort study design was used to assess the survival outcomes among 247 gastric cancer patients. All medical records of adult (≥18 years) gastric cancer patients with complete medical records of diagnosis, stage of cancer, and treatment regimen in the study setting in the last 5 years (2016–2020) were included. A simple random sampling technique was employed to select the study participants. Data were collected using a data abstraction tool composed of socio‐demographic and clinical characteristics. Survival outcomes were reported as the percentage of mortality, mean survival estimate, and mean cancer‐specific survival. The data were entered and analyzed using version 20.0 SPSS statistical software. The mean survival estimates and predictors of mortality were computed using the Kaplan–Meier and Cox regression analysis.ResultsThe study showed that 33.3% (64) had new distant metastasis, and 42.1% (104) had disease progression. Besides, the mortality rate was high (33.6%), and 14.6% and 7.7% of patients had complete and partial responses, respectively. The five‐year survival was 32.7% among gastric cancer patients. Comorbidity (p = 0.014), advanced‐stage diseases (p = 0.03), chemotherapy (p = 0.008), and gastrectomy (p = 0.016) were significant determinants of mortality.ConclusionsA significant proportion of patients had distant metastasis, disease progression, and a low five‐year survival rate. Hence, early cancer‐screening programs are indispensable to circumvent disease progression and improve survival outcomes.
miR‐31/QKI‐5 axis facilitates cell cycle progression of non‐small‐cell lung cancer cells by interacting and regulating p21 and CDK4/6 expressions
Authors: Zhu Wangyu , Yu Yun , Fang Kexin , Xiao Sisi , Ni Lianli , Yin Changtian , Huang Xiangjie , Wang Xinchen , Zhang Yongkui , Le Han‐Bo , Cui Ri 
Published: September 2022

AbstractBackgroundRNA‐binding protein Quaking‐5 (QKI‐5), a major isoform of QKIs, inhibits tumor progression in non‐small cell lung cancer (NSCLC). However, the underlying molecular mechanisms of QKI‐5 in the cell cycle of NSCLC are still largely unknown.MethodsMTT, flow cytometry, and colony formation assays were used to investigate cellular phenotypic changes. Mice xenograft model was used to evaluate the antitumor activities of QKI‐5. Co‐immunoprecipitation, RNA immunoprecipitation (RIP), and RIP sequencing were used to investigate protein–protein interaction and protein–mRNA interaction.ResultsThe QKI‐5 expression was downregulated in NSCLC tissues compared with that in paired normal adjacent lung tissues. Overexpression of QKI‐5 inhibited NSCLC cell proliferative and colony forming ability. In addition, QKI‐5 induced cell cycle arrest at G0/G1 phase through upregulating p21Waf1/Cip1 (p21) expression and downregulating cyclin D1, cyclin‐dependent kinase 4 (CDK4), and CDK6 expressions. Further analyses showed that QKI‐5 interacts with p21 protein and CDK4, CDK6 mRNAs, suggesting a critical function of QKI‐5 in cell cycle regulation. In agreement with in vitro study, the mouse xenograft models validated tumor suppressive functions of QKI‐5 in vivo through altering cell cycle G1‐phase‐associated proteins. Moreover, we demonstrated that QKI‐5 is a direct target of miR‐31. The QKI‐5 expression was anticorrelated with the miR‐31 expression in NSCLC patient samples.ConclusionOur results suggest that the miR‐31/QKI‐5/p21‐CDK4–CDK6 axis might have critical functions in the progression of NSCLC, and targeting this axis could serve as a potential therapeutic strategy for NSCLC.
The effect of training about child sexual, physical and emotional abuse
Authors: Erdoğan Çiğdem 
Published: September 2022

AbstractObjectiveThis study aims to evaluate whether the training offered about child abuse and neglect to families in which there are disagreements and problems between parents will be effective in enhancing awareness.BackgroundEven if families are the places where children are the safest, they sometimes constitute the risky groups in terms of neglect and abuse. Parents could perpetrate physical and emotional abuses against their children due to conflicts with their spouses.MethodThe research was conducted as a pre‐test–post‐test quasi‐experimental study. A total of 142 parents (71 couples) took part in the research. The Socio‐Demographic Information Form, the Abuse Awareness Scale – Parent Form and the Revised Dyadic Adjustment Scale were used as the data collection tools. Awareness training on child neglect and abuse, created by the researcher, was given to parents.ResultsBefore the training, the mean of pre‐test scores obtained by participant parents from the AAS‐PF was 62.5 ± 7.77 points. The mean of post‐test scores obtained by participant parents from the AAS‐PF was 47.5 ± 4.94 points. There was a statistically significant relationship between participant parents' AAS‐PF and RDAS scores.ImplicationsIn line with the findings obtained from the research, disagreements between spouses pose a risk for children in terms of neglect and abuse. The education program on child neglect and abuse given to parents raises awareness and reduces the risk.
Synthesis of Esters Containing Cinnamoyl Motif with Potential Larvicide Action: A Computational, Ecotoxicity and in Vitro Cytotoxicity Assessments
Authors: dos Santos Correia Paulo Ricardo , de Carvalho Cenira Monteiro , da Silva Cunha Cristhyan Rychard , da Silva Rafael Antonio Santos , de Oliveira Lima Monaly , França Saraliny Bezerra , de Oliveira Barreto Emiliano , Tonholo Josealdo , da Paz Lima Dimas José 
Published: September 2022

AbstractAn increasing morbidity and mortality rate has been related to arboviruses transmitted by Aedes aegypti. Compounds with cinnamoyl moiety represent an alternative against mosquitos, considering their larvicidal activity. This study aimed to assess the larvicidal activity of cinnamic ester derivates against Aedes aegypti larvae, along with evaluating their toxicity effect to assess its safety as a larvicide. Ethyl cinnamate demonstrated larvicidal activity (LC50=48.59 μg/mL). Morphological changes in larvae were detected, as a degenerative response in the thorax. Through molecular docking, the molecular binding mode between 3b, 3c, and acetylcholinesterase showed strong hydrogen bond interactions. Preliminary in vitro cell viability revealed the non‐cytotoxicity of 3c. Ecotoxicity results indicated a sensitivity of Artemia salina to cinnamic esters. The phytotoxicity bioassays show potential for cinnamic compounds to enhance germination and root development. These findings suggest that compound 3c is more suitable as a larvicide since it demonstrated low toxicity.
Membrane Fabrication for Carbon Dioxide Separation: A Critical Review
Authors: Shi Linggao , Lai Li Sze , Tay Wee Horng , Yeap Swee Pin , Yeong Yin Fong 
Published: September 2022

AbstractMembrane fabrication methods, mechanisms, and modification of membranes for CO2 separation are discussed. Various types of membrane materials with high CO2 separation performance are summarized. Rapid prototyping can achieve precise control of the thickness of membranes and freely design the spatial structure of membranes, which provides a new development direction for material application and process combination. Hence, a critical comparison of membrane fabrication using different methods can provide a comprehensive overview on the potential of the rapid prototyping technology in membrane fabrication. This is important to demonstrate the prospects of the membrane technology development for CO2 separation.
Embedded active impedance source inverter: Analysis and implementation
Authors: Ranjbarizad Vida , Babaei Ebrahim , Cecati Carlo 
Published: September 2022

AbstractIn this paper, a new active impedance source inverter with a suitable control method based on the pulse‐width modulation (PWM) technique is proposed. Based on the proposed control method, the analysis of the proposed inverter in different operating modes is given, and its boost factor is calculated. Then, the fundamental equations to design the values of inductors and capacitors are presented. Also, comparative analysis from different points of view, such as boost factor, voltage stresses on capacitors, and total voltage blocked by diodes and switches, between the proposed topology and conventional structures to examine the advantage and disadvantages is done. Comparison results show that the proposed topology has fewer voltage stresses on capacitors and total voltage blocked by diodes and switches. Also, it has fewer elements and continues input current and a more straightforward structure. The proposed topology's losses and efficiency at different loads are fully calculated. Finally, a prototype of the proposed topology is designed, and its experimental results along with simulation results by PSCAD to check the proposed topology's good performance and correctness of the obtained equations in different operating modes are provided.
Future scenarios for improving Iran's overall destination image and attractiveness: A supply‐side perspective
Authors: Nematpour Mohammad , Khodadadi Masood , Makian Sarasadat , Ghaffari Mohammad 
Published: September 2022

AbstractSince overall image and attractiveness can play a key role in developing a destination's tourism market, the current study attempts to identify the main factors influencing Iran's overall image and attractiveness from a supply‐side perspective. To reduce the uncertainties in Iran's future tourism market development, we first used factor analysis to identify factors that affect Iran's tourism market. Second, we used multiple linear regressions to examine the relationships between the identified factors and Iran's overall image and attractiveness as a destination. According to the findings, political, product, and service factors significantly affect Iran's overall image and attractiveness. Third, we provided scenarios for improving Iran's overall image and attractiveness based on cross‐impact balanced analysis.
Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted CEST (GluCEST) imaging
Authors: Lucas Alfredo , Nanga Ravi Prakash Reddy , Hadar Peter , Chen Stephanie , Gibson Adam , Oechsel Kelly , Elliott Mark A. , Stein Joel M. , Das Sandhitsu , Reddy Ravinder , Detre John A. , Davis Kathryn A. 
Published: September 2022

AbstractTemporal lobe epilepsy (TLE) is one of the most common subtypes of focal epilepsy, with mesial temporal sclerosis (MTS) being a common radiological and histopathological finding. Accurate identification of MTS during presurgical evaluation confers an increased chance of good surgical outcome. Here we propose the use of glutamate‐weighted chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) at 7 Tesla for mapping hippocampal glutamate distribution in epilepsy, allowing to differentiate lesional from non‐lesional mesial TLE. We demonstrate that a directional asymmetry index, which quantifies the relative difference between GluCEST contrast in hippocampi ipsilateral and contralateral to the seizure onset zone, can differentiate between sclerotic and non‐sclerotic hippocampi, even in instances where traditional presurgical MRI assessments did not provide evidence of sclerosis. Overall, our results suggest that hippocampal glutamate mapping through GluCEST imaging is a valuable addition to the presurgical epilepsy evaluation toolbox.
Comprehensive guide to managing a chronic automated red cell exchange program in sickle cell disease
Authors: Cunard Robyn , Gopal Srila , Kopko Patricia M. , Dang Minh‐Uyen , Hazle Kathryn M. , Sanchez Amber P. 
Published: September 2022

AbstractSickle cell disease (SCD) is associated with significant morbidity and mortality, and limits both the quality and quantity of life. Transfusion therapy, specifically automated red cell exchange (aRCE), plays a key role in management of SCD and is beneficial for certain indications in the chronic, outpatient setting. The approach to maintain a successful chronic aRCE program for SCD is multifaceted. This review will highlight important considerations including indications for aRCE, patient selection, transfusion medicine pearls, vascular access needs, complications of therapy, aRCE prescription, and therapy optimization. Moreover, the importance of a multidisciplinary approach with frequent communication between the services involved cannot be overstated. Ultimately, the underlying goal of a chronic RCE program is to improve the quality of life and longevity of patients with SCD.
“Ghost imaging” in pericardial cavity: Disappeared “tumor‐like” masses in tuberculous pericarditis
Authors: Chen Tienan , Wang Tingting , Yan Yingqun , Qiao Shuai , Xu Xiaona , Che Jingjin , Li Guangping , Fu Huaying 
Published: September 2022

AbstractA 66‐year‐old woman was admitted to our hospital due to chest distress and shortness of breath during 1 week. Transthoracic echocardiography (TTE) revealed massive pericardial effusion and multiple, irregular and high‐density echo “tumor‐like” masses on the heart, with the largest one on the apex. However, there were no masses found by computed tomography (CT) scan, except for increased lipids around the coronary artery. We performed emergency pericardiocentesis and drainage to relieve symptoms. The positron emission tomography/CT (PET/CT) also showed several ununiformly high accumulations in pericardial cavity. However, the high‐density echo “tumor‐like” masses cannot be seen by TTE after pericardiocentesis, and also cannot be detected when surgery. Pericardiotomy was performed due to severe pericardial adhesion. The diagnosis of tuberculosis (TB) was confirmed by pericardiotomy and pericardial biopsy.
Systematic review and meta‐analysis of sleep quality in inactive inflammatory bowel disease
Authors: Barnes Alex , Mountifield Réme , Baker Justin , Spizzo Paul , Bampton Peter , Mukherjee Sutapa 
Published: September 2022

AbstractPoor sleep in people with inflammatory bowel disease (IBD) has been demonstrated to be prevalent and has been associated with disease activity. This meta‐analysis aimed to assess the prevalence of poor sleep in inactive IBD and in controls by considering cohort and cross‐sectional studies. Electronic databases were searched for publications from inception to 1 November 2021. Poor sleep and IBD activity were defined according to self‐reported subjective sleep measures. A random effects model was used to determine the standardized mean difference between poor sleep in inactive IBD and healthy controls. Publication bias was assessed by funnel plot and Egger's test. Five hundred and nineteen studies were screened with 9 studies included in the meta‐analysis incorporating a total of 729 people with IBD and 508 controls. A random effects model showed a standardized mean difference with poor sleep being more frequent in those with inactive IBD than controls with moderate effect size (Hedge's g 0.41, CI [0.22–0.59]) and no significant heterogeneity. There was no publication bias evident. Poor sleep is more common in individuals with inactive IBD than healthy controls. Further studies should consider potential mechanisms to explain this result, including the role of subclinical inflammation and psychosocial factors that may influence sleep quality in people with IBD.
The Effects of Leader Support for Creativity and Leader Gender on Subordinate Creative Problem‐Solving Performance
Authors: Maliakkal Nadine T. , Reiter‐Palmon Roni 
Published: September 2022

ABSTRACTAmple correlational research shows that leader support for creativity is related to subordinate creativity, yet research examining the causality of this relationship experimentally is scant. Furthermore, most studies that demonstrate support for this relationship have used relatively subjective creativity measures that do not tap as effectively into the creative problem‐solving process. Thus, we experimentally examined whether leader support for creativity affects subordinate creative problem‐solving performance. We also examined whether this relationship depends on leader gender. We used experimental vignette methodology and a sample of 247 working adults to test these relationships. We found that high (vs. low) leader support for creativity resulted in a significantly higher number of ideas generated. Additionally, posthoc analyses showed that high (vs. low) leader support for creativity resulted in a significantly higher number of original ideas and higher number of quality ideas generated. We also found that when the leader was a woman (vs. man), average originality of ideas was significantly higher. We found no significant interactive effects of leader support for creativity and leader gender. We discuss how this study further elucidates our understanding of leader support for creativity, as well as avenues for future creativity research involving leader gender.
Baricitinib for atopic dermatitis patients who responded inadequately to dupilumab treatment: First daily practice results
Authors: de Wijs Linde , Schreurs Corine , Schlösser Anne , Nijsten Tamar , Hijnen Dirk Jan 
Published: September 2022

AbstractBackgroundBaricitinib is the first JAK inhibitor registered for the treatment of moderate‐to‐severe atopic dermatitis (AD). Efficacy and safety were shown in clinical trials, but daily practice data is sparse.ObjectivesTo evaluate the effectiveness and safety of baricitinib treatment in daily practice in AD patients who have inadequately responded to dupilumab.MethodsIn this prospective observational cohort study, AD patients who failed dupilumab treatment and started baricitinib treatment in context of standard care at the Erasmus MC (the Netherlands) were included. We analysed physician‐reported scores and patient‐reported outcome measure scores (PROMs).ResultsTwenty‐five patients were included. Baricitinib treatment resulted in significant improvement of Eczema Area and Severity Index (EASI) scores and PROMs. Seven patients showed a good and sustained response (EASI50), eight patients showed no response (<EASI50), and five patients showed an initial response but worsening of EASI scores in time. Overall, baricitinib was well tolerated. Four patients discontinued baricitinib treatment due to ineffectiveness or side effects.ConclusionsBaricitinib can be an effective treatment for a subset of AD patients who failed dupilumab treatment in daily practice. We found three different treatment response groups including responders, temporarily responders, and non‐responders.
Effect of boiling and roasting processing on nutritional quality of two Sudanese peanuts (Arachis hypogaea) cultivars
Authors: Eltom Hind A. E. , Sulieman Mashair A. , Hassan Amro B. 
Published: September 2022

AbstractThis study was conducted to investigate the effect of boiling, roasting and boiling followed by roasting treatments on the nutritional quality of two Sudanese peanut cultivars, Sodari and Madani. Both cultivars are rich in fat content, protein content and bioavailability of macroelements and microelements. The thermal treatments were critical, reduced the antinutrients factors, and significantly (P < 0.05) enhanced the in vitro protein digestibility of the peanut samples. The highest values 78% and 79.2%, for Madani and Sodari cultivars, were obtained after boiling and roasting processing. However, the thermal processing caused a reduction in the vitamin E content of peanuts. In general, boiled and roasted peanuts could serve as a critical, underutilized by‐product, particularly after combining boiling and roasting treatments, for potential applications in food formulations.
Easy care of silk fabrics realized by crosslinking thermo‐responsive copolymer film on its surface
Authors: Zhu Xiaoju , Hu Neng , Xu Zheng , Cai Xin , Müller‐Buschbaum Peter , Zhong Qi 
Published: September 2022

AbstractAn easy care of silk fabrics is realized by crosslinking a thermo‐responsive copolymer film onto its surface. The thermo‐responsive copolymer poly(N‐isopropylacrylamide‐co‐oligo[ethylene glycol] methyl ether methacrylate‐co‐ethylene glycol methacrylate), abbreviated as P(NM‐co‐OA300‐co‐EA360), is synthesized by sequential atom transfer radical polymerization. By applying 1,2,3,4‐butanetetracarboxylic acid as crosslinker, the thermo‐responsive P(NM‐co‐OA300‐co‐EA360) film can be immobilized onto the silk fabrics. The transition temperature (TT) of the P(NM‐co‐OA300‐co‐EA360) film crosslinked on silk fabrics is around 46 °C. The reversible transition behavior can effectively reduce the attachment between lipophilic stains and P(NM‐co‐OA300‐co‐EA360) film, inducing a high efficiency of stain removal. Simply rinsing with deionized water at 25 °C (below its TT) for 30 s, 60% of stains can be removed. Moreover, the crosslinked P(NM‐co‐OA300‐co‐EA360) film turns hydrophobic during outdoor activities or drying. Thus, the repelled water molecules can be easily evaporated from the silk fabrics and the drying process is 25% faster than that without crosslinked P(NM‐co‐OA300‐co‐EA360) film. Based on the excellent performance of stain removal and quick drying, the silk fabrics crosslinked with thermo‐responsive copolymer film can be broadly used to design silk‐based costumes for daily use.