bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Statewide Limitations of Practice on High School Injury Incidence During the COVID-19 Season: An Ecological Study
Authors: Bullock Garrett , Prats-Uribe Albert , Thigpen Charles A. , Boyer Lisa , Varnado Kate , Pequette Jason , Shanley Ellen 
Published: June 2022

Background: Abrupt training stoppage can increase injury incidence and risk following return to sport. The rate of coronavirus disease 2019 (COVID-19) infections in the general population has resulted in the abrupt stoppage of high school education and sport. The objective of this study was to (1) compare injury incidence proportion (IP) and excess injury in high school athletes before and during the COVID-19 pandemic; and (2) stratify by identified gender. Hypothesis: The COVID-19 academic year will demonstrate increased injury incidence, and injury incidence will be similar between genders. Study Design: Ecological. Level of Evidence: Level 2. Methods: High schools (6 states; 176 high schools) were matched between prepandemic and pandemic years. Injury IP with 95% confidence interval (CI) was calculated. Interrupted time series models with robust errors were performed to assess the IP ratio and excess injury incidence between prepandemic and pandemic academic calendar years. Results: A total of 98,487 athletes participated in high school sport in the prepandemic year and 72,521 athletes in the pandemic year; 15,477 injuries were reported in the prepandemic year compared with 14,057 injuries during the pandemic year. Injury IP (CI) was 15.7 (15.5-15.9) and 19.4 (19.1-19.7) for the prepandemic and pandemic years, respectively. Injury incidence ratio increased by 1.3 (1.2-1.5) between the prepandemic and pandemic years. Excess injuries were 1812 greater in the pandemic year compared with the prepandemic year. Female and male athlete incidence ratios were similar. Conclusion: Prolonged sport stoppage due to the COVID-19 pandemic resulted in increased injury incidence compared with the previous high school academic year. Clinical Relevance: High school sports stakeholders should consider longer periods of ramp up for training in lieu of future sport stoppages compared with usual preseason training. These data may also have more generalizable implications to other abrupt sport and physical activity stoppage scenarios such as earthquakes and hurricanes.
Telehealth: A new paradigm? Paediatric surgical subspecialty telemedicine survey in the COVID-19 Pandemic at a tertiary care centre
Authors: Shin Yu Jin , Mohanty Amrita , Kang Audry , Judge Clark E , Baroody Fuad M , Shogan Andrea , Rodriguez Sarah H , Reid Russell R , Frim David , Chokshi Nikunj K , Mak Grace , Slidell Mark B , Lee Thomas K , Kandel Jessica , Truehart Amber , Gundeti Mohan S 
Published: June 2022

Background: Although the technology has been available and several pilot studies have shown success, use of telemedicine has previously been limited in the United States, especially among surgeons. This study aimed to investigate the benefits and obstacles for successful implementation of telemedicine visits in paediatric surgical subspecialties amid the COVID-19 pandemic. Methods: We analysed survey data from telemedicine visits with paediatric surgical subspecialists from May 1 through June 30, 2020 at our paediatric surgery subspecialty clinics. Univariate logistic regression was used to determine associations in survey responses and various demographic factors. Results: There were 164 respondents to the survey. The most frequently cited barrier to care was ability to get time off work (46.3%). Overall satisfaction with the telemedicine visit was 93.8%, and 55.6% responded that they would choose video telemedicine rather than an in-person or telephone visit. Those living at least 25 miles from the hospital had increased odds of indicating interest in using telemedicine for future visits (OR = 2.56, 95% CI = 1.12–5.86, p = 0.026). The average respondent saved between 30 minutes and 1 hour, and 45 minutes using telemedicine. Conclusions: The implementation of telemedicine at our institution in the paediatric surgical subspecialties has proven to be effective and well-received. Given the benefits of time and money saved for families, paired with high satisfaction rates and continued interest, paediatric surgical subspecialists should work to incorporate virtual visits into regular patient care, even well after the COVID-19 pandemic. Level of Evidence: Level IV
Perceived severity of COVID-19, social support, and pandemic-related stress associated with lifestyle changes among undergraduate students in Indonesia
Authors: Khaira Fathiyyatul , Sari Liliyana 
Published: June 2022

Introduction: COVID-19 affects lifestyles, including those of undergraduate students who are one of the most vulnerable populations. This study aimed to describe changes in lifestyle-related behaviors and assess the correlation between the perceived risk of COVID-19, social support, perceived stress, and lifestyle changes among undergraduate students during the pandemic. Design and methods: A total of 547 students from 32 provinces in Indonesia completed online questionnaires comprising four measures: perceived risk of COVID-19, the Lifestyle-related Behavior Questionnaire, the Multidimensional Scale of Perceived Social Support, and the Pandemic-related Perceived Stress Scale. Results: Undergraduate students who lived with their families had healthier lifestyles than students who lived alone ( p = 0.007). Furthermore, The Pearson’s correlation showed a significant correlation between lifestyle changes with perceived severity ( r = 0.107; p < 0.05), social support ( r = 0.237; p < 0.001and pandemic-related stress ( r = −0.304, p < 0.001). Higher perceived severity of COVID-19 and social support were associated with a healthier lifestyle, whereas increased stress correlated with a less healthy lifestyle. Conclusion: Psychological factors correlated with lifestyle changes of Indonesian undergraduate students during the pandemic. Therefore, psychological aspects should be more considered by relatives and institutions to ensure healthier lifestyles of students.
Relationship of heat stress with acute kidney disease and chronic kidney disease: A literature review
Authors: Alayyannur Putri Ayuni , Ramdhan Doni Hikmat 
Published: June 2022

Introduction: Heat stress is a physical hazard and a potential health risk which can result in various conditions ranging from discomfort, headaches, psychological disorders, heat stroke and even death in extreme cases. Factors which cause heat stress include high ambient temperature, limited air movement, strenuous physical work and direct exposure to the heat of the engine/ sun. Continuous heat stress, exacerbated by dehydration, can lead to kidney disease. This study is a literature review conducted to explore factors that influence heat stress and the relationship of heat stress with acute kidney disease and chronic kidney disease. Methods: Literature search was conducted in September 2021. Research sources were taken from several databases, namely Science Direct, ProQuest, PubMed, and Google Scholar. From the databases, 23,316 articles were from Science Direct, 140,319 articles were from ProQuest, 670 articles were from PubMed, and 288,000 articles were from Google Scholars. Out of the total database only 24 articles met the inclusion criteria. The variables in this study were heat stress, acute kidney disease, and chronic kidney disease. Results: This literature review shows that several factors which can affect heat stress are heat exposure, workload, rehydration, and rest period arrangements. Heat stress experienced by workers can cause decreased kidney function and chronic kidney disease. Heat stress conditions that are continuously experienced by workers can cause chronic kidney disease. Conclusion: Heat stress can be experienced by workers due to heat exposure, heavy workload, poor rehydration, and poor rest period arrangements. Heat stress can cause acute kidney disease and chronic kidney disease.
Influence of Patellofemoral Anatomy on Outcomes of Isolated Medial Patellofemoral Ligament Reconstruction for Recurrent Patellar Instability
Authors: Pappa Nicholas , Flanigan David C. , Long Joseph , Dorweiler Matthew , Fowler Brian , Duerr Robert , Dibartola Alex C. , Kaeding Christopher K. , Magnussen Robert A. 
Published: June 2022

Background: Patella alta and elevated tibial tubercle–trochlear groove (TT-TG) distance can predispose patients to lateral patellar dislocations and recurrent instability. Their influence on patient-reported outcomes (PROs) after medial patellofemoral ligament (MPFL) reconstruction is less clear. Hypothesis: We hypothesized that neither moderately increased TT-TG distance nor patella alta would negatively affect PROs after isolated MPFL reconstruction in patients with relatively normal patellar tracking (no large J-sign). Study Design: Cohort study; Level of evidence, 3. Methods: We identified patients who underwent isolated MPFL reconstruction at a single institution between 2008 and 2016. The decision to perform an isolated MPFL reconstruction was at the discretion of the operating surgeon but was not performed in the setting of a large J-sign. Patient characteristics and surgical details were collected, and patients completed the Norwich Patellar Instability Score, Knee injury and Osteoarthritis Outcome Score, and Marx activity score. Patellar height (Caton-Deschamps Index [CDI]) was assessed on preoperative lateral radiographs, and TT-TG distance was measured on preoperative axial magnetic resonance imaging (MRI) scans. Patients were grouped based on CDI and TT-TG distance, and outcomes were compared. Linear regression modeling was performed to determine whether patella alta or elevated TT-TG distance was associated with poorer PRO scores. Results: Of 165 knees in 152 patients who underwent isolated MPFL reconstruction, 115 patients (125 knees; 76%) with minimum 1-year follow-up were contacted at a mean of 5.2 years after surgery. Recurrent dislocation occurred in 5 of 125 knees (4%). Preoperative radiographs were available in 111 knees (89%), and preoperative MRI scans were available in 89 knees (71%). Mean CDI was 1.13, and 35% had a CDI ≥1.20. Mean TT-TG distance was 17.5 mm, and 26% had a TT-TG distance >20 mm. After adjusting for patient age, sex, body mass index, and graft choice, we observed that neither patella alta nor elevated TT-TG distance were associated with poorer PROs. Conclusion: Isolated MPFL reconstruction in the setting of moderately elevated TT-TG distance or patella alta was not associated with worse PROs in this cohort with relatively normal patellar tracking (no large J-sign).
Characteristics of Cyber Sextortion in India: Content Analysis of Online Newspapers Published in 2019–2021
Authors: Mondal Himel , Sahoo Manas Ranjan , Mondal Shaikat 
Published: June 2022

Introduction: Smartphones and Internet connection help people to stay connected to virtual social media where predators may disguise and obtain intimate text, audio, photographs, and video from the victim. These are then used to extort money, sexual act, or any other favors. Aim: We aimed to observe the characteristics of cyber sextortion in India in recent years (2019–2021). Methods: This was a cross-sectional observational study conducted in February 2022. The cases of cyber sextortion reported in newspapers between 2019 and 2021 were considered for qualitative analysis. The cases were thematically analyzed by 2 authors individually and a consensus was reached for the finalization of the finding. Results: Social media and dating applications are used to lure the victims to exchange sexual text, intimate photo, or video. The contents are saved and used as a tool to extort money, sexual acts, or other favors. The males are commonly extorted for money but females are extorted for money and sexual acts. The victim may be called for a sexual act in a place and a group of extortionists may appear in the scene. Exchange of text messages or audio calls are also recorded for extortion. Personal intimate contents obtained from remote access of device or access through a third person or morphing videos are also used for sextortion. Conclusion: Social media engagement and a desire of exploring sexual relations with unknown persons expose the victims for sextortion. Storing and sharing intimate content should be avoided even when in trusted relations to minimize the risk.
Greater Perceptions of Economic Deprivation in Childhood Are Associated With More Sexual Risk Behaviors in Adulthood via Younger Age of Sexual Initiation
Authors: Hammett Julia F. , Davis Kelly Cue 
Published: June 2022

Introduction: Sexual risk behaviors are a public health concern. Although sexual risk behaviors are overrepresented among economically disadvantaged individuals, the mechanisms underlying the link from economic deprivation to sexual risk behaviors are not well understood. Aim: The purpose of this study was to investigate whether one of the earliest indicators of sexual risk, age of sexual initiation, mediates the link between young men’s perceptions of economic deprivation while growing up and sexual risk behaviors in adulthood. Method: Six-hundred twenty-four men provided data on background variables and risk. Path analyses were conducted in Mplus Version 8. Results: Perceptions of economic deprivation while growing up were related to younger age of sexual initiation, which in turn was related to higher risk for sex earlier in a relationship, condomless sex, sexually transmitted infections, unintended pregnancy, and condom use resistance. Conclusion: These findings highlight important avenues for sexual health and health equity promotion.
Hyb4mC: a hybrid DNA2vec-based model for DNA N4-methylcytosine sites prediction
Authors: Liang Ying , Wu Yanan , Zhang Zequn , Liu Niannian , Peng Jun , Tang Jianjun 
Published: June 2022

Abstract
Background
DNA N4-methylcytosine is part of the restrictive modification system, which works by regulating some biological processes, for example, the initiation of DNA replication, mismatch repair and inactivation of transposon. However, using experimental methods to detect 4mC sites is time-consuming and expensive. Besides, considering the huge differences in the number of 4mC samples among different species, it is challenging to achieve a robust multi-species 4mC site prediction performance. Hence, it is of great significance to develop effective computational tools to identify 4mC sites.

Results
This work proposes a flexible deep learning-based framework to predict 4mC sites, called Hyb4mC. Hyb4mC adopts the DNA2vec method for sequence embedding, which captures more efficient and comprehensive information compared with the sequence-based feature method. Then, two different subnets are used for further analysis: Hyb_Caps and Hyb_Conv. Hyb_Caps is composed of a capsule neural network and can generalize from fewer samples. Hyb_Conv combines the attention mechanism with a text convolutional neural network for further feature learning.

Conclusions
Extensive benchmark tests have shown that Hyb4mC can significantly enhance the performance of predicting 4mC sites compared with the recently proposed methods.
Multi-probe attention neural network for COVID-19 semantic indexing
Authors: Gu Jinghang , Xiang Rong , Wang Xing , Li Jing , Li Wenjie , Qian Longhua , Zhou Guodong , Huang Chu-Ren 
Published: June 2022

AbstractBackgroundThe COVID-19 pandemic has increasingly accelerated the publication pace of scientific literature. How to efficiently curate and index this large amount of biomedical literature under the current crisis is of great importance. Previous literature indexing is mainly performed by human experts using Medical Subject Headings (MeSH), which is labor-intensive and time-consuming. Therefore, to alleviate the expensive time consumption and monetary cost, there is an urgent need for automatic semantic indexing technologies for the emerging COVID-19 domain.ResultsIn this research, to investigate the semantic indexing problem for COVID-19, we first construct the new COVID-19 Semantic Indexing dataset, which consists of more than 80 thousand biomedical articles. We then propose a novel semantic indexing framework based on the multi-probe attention neural network (MPANN) to address the COVID-19 semantic indexing problem. Specifically, we employ a k-nearest neighbour based MeSH masking approach to generate candidate topic terms for each input article. We encode and feed the selected candidate terms as well as other contextual information as probes into the downstream attention-based neural network. Each semantic probe carries specific aspects of biomedical knowledge and provides informatively discriminative features for the input article. After extracting the semantic features at both term-level and document-level through the attention-based neural network, MPANN adopts a linear multi-view classifier to conduct the final topic prediction for COVID-19 semantic indexing.ConclusionThe experimental results suggest that MPANN promises to represent the semantic features of biomedical texts and is effective in predicting semantic topics for COVID-19 related biomedical articles.
In silico characterization, molecular phylogeny, and expression profiling of genes encoding legume lectin-like proteins under various abiotic stresses in Arabidopsis thaliana
Authors: Biswas Subhankar , Mondal Raju , Srivastava Akanksha , Trivedi Maitri , Singh Sunil Kumar , Mishra Yogesh 
Published: June 2022

Abstract
Background
Lectin receptor-like kinases (Lec-RLKs), a subfamily of RLKs, have been demonstrated to play an important role in signal transduction from cell wall to the plasma membrane during biotic stresses. Lec-RLKs include legume lectin-like proteins (LLPs), an important group of apoplastic proteins that are expressed in regenerating cell walls and play a role in immune-related responses. However, it is unclear whether LLPs have a function in abiotic stress mitigation and related signaling pathways. Therefore, in this study, we examined the possible role of LLPs in Arabidopsis thaliana (AtLLPs) under various abiotic stresses.

Results
The study was initiated by analyzing the chromosomal localization, gene structure, protein motif, peptide sequence, phylogeny, evolutionary divergence, and sub-cellular localization of AtLLPs. Furthermore, the expression profiling of these AtLLPs was performed using publicly accessible microarray datasets under various abiotic stresses, which indicated that all AtLLPs were differently expressed in both root and shoot tissues in response to abiotic stresses. The cis-regulatory elements (CREs) analysis in 500 bp promoter sequences of AtLLPs suggested the presence of multiple important CREs implicated for regulating abiotic stress responses, which was further supported by expressional correlation analysis between AtLLPs and their CREs cognate transcription factors (TFs). qRT-PCR analysis of these AtLLPs after 2, 6, and 12 h of cold, high light, oxidative (MV), UV-B, wound, and ozone stress revealed that all AtLLPs displayed differential expression patterns in most of the tested stresses, supporting their roles in abiotic stress response and signaling again. Out of these AtLLPs, AT1g53070 and AT5g03350 appeared to be important players. Furthermore, the mutant line of AT5g03350 exhibited higher levels of ROS than wild type plants till 12 h of exposure to high light, MV, UV-B, and wound, whereas its overexpression line exhibited comparatively lower levels of ROS, indicating a positive role of this gene in abiotic stress response in A. thaliana.

Conclusions
This study provides basic insights in the involvement of two important representative AtLLPs, AT1g53070 and AT5g03350, in abiotic stress response. However, further research is needed to determine the specific molecular mechanism of these AtLLPs in abiotic stress mitigation and related signaling pathways in A. thaliana.
Acute hepatitis B virus infection despite vaccination in a patient treated by infliximab: a case report
Authors: Besombes Juliette , Souala Faouzi , Bouguen Guillaume , Guyader Dominique , Grolhier Claire , Thibault Vincent , Pronier Charlotte 
Published: June 2022

Abstract
Background
Despite an effective vaccine, hepatitis B remains a major global health problem due to its significant morbidity and mortality. Vaccination in immunosuppressed patients such as those treated for an inflammatory bowel disease (IBD) can be less effective. This case describes an uncommon original diagnosis of an acute hepatitis B infection occurring in a vaccinated but immunocompromised IBD patient under long-term infliximab treatment. A low anti-HBs titer and the presence of HBsAg escape mutations are possible hypotheses to explain this unexpected infection.

Case presentation
A 28-year-old Caucasian male, regularly followed-up for a Crohn’s disease treated by infliximab, was regularly screened for sexually transmissible infections because of at-risk behaviors. Despite a correct immunization scheme against hepatitis B virus (HBV), an active HBV infection was diagnosed during one of those screenings. Retrospective testing of a sample collected 6 months earlier was in favor of an evolution from an acute hepatitis B toward a chronic hepatitis B. The patient has always had a low anti-HBs antibody levels (near the threshold of 10 IU/L) possibly explaining his infection. In addition, HBV sequencing revealed a genotype A2 HBV strain, carrying the sD144A substitution on the S protein, known as a potential immune escape variant. Dual therapy combining tenofovir disoproxil fumarate and emtricitabine, active against HBV but also efficient as an HIV pre-exposure prophylaxis, was initiated. Ten months after treatment initiation, all surrogate biochemical and virological endpoints for HBV functional cure were achieved. Treatment and periodical monitoring are being maintained.

Conclusion
Emphasis should be placed on HBV screening, vaccination and regular monitoring of patients under long-term immunosuppressive therapy, particularly those with at-risk behaviors.