bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of math anxiety and its remediation through a digital training program in mathematics for first and second graders
Authors: Ng Chan‐Tat , Chen Yin‐Hua , Wu Chao‐Jung , Chang Ting‐Ting 
Published: March 2022

AbstractIntroductionMath anxiety severely impacts individuals’ learning and future success. However, limited is understood about the profile in East Asian cultures where students genuinely show high‐level math anxiety, despite that they outperform their Western counterparts. Here, we investigate the relation between math anxiety and math achievement in children as young as first and second graders in Taiwan. Further, we evaluate whether intensive exposure to digital game‐based learning in mathematics could ameliorate math anxiety.MethodsThe study first evaluated a group of 159 first and second graders’ math anxiety and its correlation with math performance. Subsequently, a quasi‐experimental design was adopted: 77 of the children continued and participated in multi‐component digital game training targeting enumeration, speeded calculation, and working memory. Post‐assessment was administered afterward for further evaluation of training‐associated effects.ResultsResults confirmed that math anxiety was negatively associated with school math achievement, which assessed numerical knowledge and arithmetic calculation. Furthermore, children's math anxiety was remarkably reduced via digital training in mathematics after 6‐week intensive remediation. Crucially, this math anxiety relief was more prominent in those with high‐level math anxiety. Although the children who underwent the training showed training‐induced math achievement and working memory enhancement, this cognitive improvement appeared to be independent of the math anxiety relief.ConclusionOur findings demonstrate that students can show highly negative emotions and perceptions toward learning even in high‐achieving countries. Auspiciously, the feeling of distress toward learning has the feasibility to be relieved from short‐term intensive training. Our study suggests a new approach of early treatments to emotional disturbance that can lead to permanent consequences in individuals.
Performance status (PS) as a predictor of poor response to immune checkpoint inhibitors (ICI) in recurrent/metastatic head and neck cancer (RMHNSCC) patients
Authors: Chalker Cameron , Voutsinas Jenna M. , Wu Qian Vicky , Santana‐Davila Rafael , Hwang Victoria , Baik Christina S. , Lee Sylvia , Barber Brittany , Futran Neal D. , Houlton Jeffrey J. , Laramore George E. , Liao Jay Justin , Parvathaneni Upendra , Martins Renato G. , Eaton Keith D. , Rodriguez Cristina P. 
Published: March 2022

AbstractBackgroundAnti‐PD1 checkpoint inhibitors (ICI) represent an established standard‐of‐care for patients with recurrent/metastatic head and neck squamous cell carcinoma (RMHNSCC). Landmark studies excluded patients with ECOG performance status (PS) ≥2; the benefit of ICI in this population is therefore unknown.MethodsWe retrospectively reviewed RMHNSCC patients who received 1+ dose of ICI at our institution between 2013 and 2019. Demographic and clinical data were obtained; the latter included objective response (ORR), toxicity, and any unplanned hospitalization (UH). Associations were explored using uni‐ and multivariate analysis. Overall survival (OS) was estimated using a Cox proportional hazards model; ORR, toxicity, and UH were evaluated with logistic regression.ResultsOf the 152 patients, 29 (19%) had an ECOG PS ≥2. Sixty‐six (44%) experienced toxicity; 54 (36%) had a UH. A multivariate model for OS containing PS, smoking status, and HPV status demonstrated a strong association between ECOG ≥2 and shorter OS (p < 0.001; HR = 3.30, CI = 2.01–5.41). An association between OS and former (vs. never) smoking was also seen (p < 0.001; HR = 2.17, CI = 1.41–3.35); current smoking did not reach statistical significance. On univariate analysis, poor PS was associated with inferior ORR (p = 0.03; OR = 0.25, CI = 0.06–0.77) and increased UH (p = 0.04; OR = 2.43, CI = 1.05—5.71). There was no significant association between toxicity and any patient characteristic.ConclusionsWe observed inferior OS, ORR, and rates of UH among ICI‐treated RMHNSCC patients with ECOG 2/3. Our findings help frame discussion of therapeutic options in this poor‐risk population.
Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2
Authors: Bennett Megan , Ducrot Laurine , Vergne‐Vaxelaire Carine , Grogan Gideon 
Published: March 2022

AbstractNative amine dehydrogenases (nat‐AmDHs) have recently emerged as a potentially valuable new reservoir of enzymes for the sustainable and selective synthesis of chiral amines, catalyzing the NAD(P)H‐dependent ammoniation of carbonyl compounds with high activity and selectivity. MATOUAmDH2, recently identified from the Marine Atlas of Tara Oceans Unigenes (MATOUv1) database of eukaryotic genes, displays exceptional catalytic performance against its best identified substrate, isobutyraldehyde, as well as having broader substrate scope than other nat‐AmDHs. In the interests of providing a platform for the rational engineering of this and other nat‐AmDHs, we have determined the structure of MATOUAmDH2 in complex with NADP+and also with the cofactor and cyclohexylamine. Monomers within the structure are representative of more open and closed conformations of the enzyme and illustrate the profound changes undergone by nat‐AmDHs during the catalytic cycle. An alanine screen of active site residues revealed that M215A and L180A are more active than the wild‐type enzyme for the amination of cyclohexanone with ammonia and methylamine respectively; the latter suggests that AmDHs have the potential to be engineered for the improved production of secondary amines.
Detection of disease‐causing mutations in prostate cancer by NGS sequencing
Authors: Mangolini Alessandra , Rocca Christian , Bassi Cristian , Ippolito Carmelo , Negrini Massimo , Dell'Atti Lucio , Lanza Giovanni , Gafà Roberta , Bianchi Nicoletta , Pinton Paolo , Aguiari Gianluca 
Published: March 2022

AbstractGene mutations may affect the fate of many tumors including prostate cancer (PCa); therefore, the research of specific mutations associated with tumor outcomes might help the urologist to identify the best therapy for PCa patients such as surgical resection, adjuvant therapy or active surveillance. Genomic DNA (gDNA) was extracted from 48 paraffin‐embedded PCa samples and normal paired tissues. Next, gDNA was amplified and analyzed by next‐generation sequencing (NGS) using a specific gene panel for PCa. Raw data were refined to exclude false‐positive mutations; thus, variants with coverage and frequency lower than 100× and 5%, respectively were removed. Mutation significance was processed by Genomic Evolutionary Rate Profiling, ClinVar, and Varsome tools. Most of 3000 mutations (80%) were single nucleotide variants and the remaining 20% indels. After raw data elaboration, 312 variants were selected. Most mutated genes were KMT2D (26.45%), FOXA1 (16.13%), ATM (15.81%), ZFHX3 (9.35%), TP53 (8.06%), and APC (5.48%). Hot spot mutations in FOXA1, ATM, ZFHX3, SPOP, and MED12 were also found. Truncating mutations of ATM, lesions lying in hot spot regions of SPOP and FOXA1 as well as mutations of TP53 correlated with poor prognosis. Importantly, we have also found some germline mutations associated with hereditary cancer‐predisposing syndrome. gDNA sequencing of 48 cancer tissues by NGS allowed to detect new tumor variants as well as confirmed lesions in genes linked to prostate cancer. Overall, somatic and germline mutations linked to good/poor prognosis could represent new prognostic tools to improve the management of PCa patients.
International percutaneous coronary intervention complication survey
Authors: Simsek Bahadir , Kostantinis Spyridon , Karacsonyi Judit , Hall Allison , Rangan Bavana V. , Croce Kevin J. , Azzalini Lorenzo , McEntegart Margaret , Shishehbor Mehdi , Egred Mohaned , Mastrodemos Olga C. , Sorajja Paul , Banerjee Subhash , Lombardi William , Sandoval Yader , Brilakis Emmanouil S. 
Published: March 2022

AbstractObjectivesTo investigate the perceptions of interventional cardiologists (IC) regarding the frequency, impact, and management strategies of percutaneous coronary intervention (PCI) complications.BackgroundThe perceptions and management strategies of ICs of PCI complications have received limited study.MethodsOnline survey on PCI complications: 46 questions were distributed via email lists and Twitter to ICs.ResultsOf 11,663 contacts, 821 responded (7% response rate): 60% were from the United States and the median age was 46–50 years. Annual PCI case numbers were <100 (26%), 100–199 (37%), 200–299 (21%), and ≥300 (16%); 42% do not perform structural interventions, others reported performing <40 (30%), or >100 (11%) structural cases annually. On a scale of 0–10, participating ICs were highly concerned about potential complications with a median score of 7.2 (interquartile range: 5.0–8.7). The most feared complication was death (39%), followed by coronary perforation (26%) and stroke (9%). Covered stents were never deployed by 21%, and 32% deployed at least one during the past year; 79% have never used fat to seal perforations; 64% have never used coils for perforations. Complications were attributed to higher patient/angiographic complexity by 68% and seen as opportunities for improvement by 70%; 97% of participants were interested in learning more about the management of PCI complications. The most useful learning methods were meetings (66%), webinars (48%), YouTube (32%), and Twitter (29%).ConclusionICs who participated in the survey are highly concerned about complications. Following complication management algorithms and having access to more experienced operators might alleviate stress and optimize patient outcomes.
Silver Cyanide Powder‐Catalyzed Selective Epoxidation of Cyclohexene and Styrene with its Surface Activation by H2O2(aq) and Assisted by CH3CN as a Non‐Innocent Solvent
Authors: Lu Yu‐Jhang , Janmanchi Damodar , Natarajan Thiyagarajan , Lin Zhi‐Han , Wanna Wondemagegn H. , Hsu I‐Jui , Tzou Der‐Lii M. , Ayalew Abay Tigist , Yu Steve S.‐F. 
Published: March 2022

AbstractWe undertake silver cyanide (AgCN) powder for its catalytic epoxidation of cyclohexene or styrene in CH3CN with variable substrate‐to‐solvent volume ratios using H2O2(aq) at 60 °C. The reaction mixtures can facilely separate into organic and aqueous layers. Cyclohexene oxide can be produced in the organic layer with 100 % selectivity from the substrate cyclohexene, while styrene oxide was identified with 80 % selectivity against benzaldehyde in styrene oxidation. After reactions, we can recycle the AgCN particles with comparable bulk property clarified via XRD, XPS, XAS, FT‐IR, and 13C‐SS NMR spectroscopy. Using H218O2 as the oxidant, both epoxide products and acetamide are highly enriched with 18O‐atom, indicating that the π bond‐activation is essential for forming the cyclohexene/styrene oxides in the organic and acetamide in the aqueous layers. The oxidation of cyclohexene/styrene catalyzed by AgCN powder through surface activation by H2O2(aq) and assisted by the non‐innocent CH3CN‐originated acetamide can achieve highly selective π‐bond activation with high reactivity.
pH‐Triggered Removal of Nitrogenous Organic Micropollutants from Water by Using Metal‐Organic Polyhedra
Authors: Hernández‐López Laura , Cortés‐Martínez Alba , Parella Teodor , Carné‐Sánchez Arnau , Maspoch Daniel 
Published: March 2022

AbstractWater pollution threatens human and environmental health worldwide. Thus, there is a pressing need for new approaches to water purification. Herein, we report a novel supramolecular strategy based on the use of a metal‐organic polyhedron (MOP) as a capture agent to remove nitrogenous organic micropollutants from water, even at very low concentrations (ppm), based exclusively on coordination chemistry at the external surface of the MOP. Specifically, we exploit the exohedral coordination positions of RhII‐MOP to coordinatively sequester pollutants bearing N‐donor atoms in aqueous solution, and then harness their exposed surface carboxyl groups to control their aqueous solubility through acid/base reactions. We validated this approach for removal of benzotriazole, benzothiazole, isoquinoline, and 1‐napthylamine from water.
Influence of Si Doping on Dislocations and Mechanical Properties of GaAs Crystals Grown by Modified Vertical Bridgman Method
Authors: Zhang Hongli , Jin Min , Shen Hui , Xu Jiayue 
Published: March 2022

AbstractGaAs crystals are important III–V compound semiconductor materials and the bandgap and quantum efficiency can be optimized by doping. However, the doping may bring some problems to the crystal growth. In this paper, Si‐doped GaAs crystals are grown by the modified vertical Bridgman method and the influence of Si doping on dislocations and mechanical properties are discussed. It is found that a proper amount of Si doping significantly reduces the dislocation density of GaAs crystals. The mechanical properties of (100), (110), (111), and (511) planes are measured, and the results show that the mechanical properties of Si‐doped GaAs crystals have obvious anisotropy. The (111) plane has the strongest mechanical properties among them. The Vickers hardness, fracture toughness, nanoindentation hardness, and elastic modulus of the (111) plane are 6.05 GPa, 0.69 MPa m1/2, 10.82 GPa, 138.7 GPa, respectively. Moreover, Si doping can improve the mechanical properties of GaAs crystals.
One‐Step Fabrication of CdS/Ag2S Heterojunction Composites and Its Enhanced Visible‐Light Photocatalytic Degradation Performance
Authors: Wang Shuang , Yu Minghui , Yu Hao , Cheng Yuye , Dou Minghao , Gong Xiaoyu , Li Zhiqiang , Shao Hongyu , Chen Guangyu , Li Shenjie , Chen Yanyan 
Published: March 2022

AbstractThe design and construction of Ag2S heterostructures capable of significantly separating photocarriers is a significant challenge in photocatalysis. In this study, CdS/Ag2S heterojunction composite photocatalyst is fabricated through a simple one‐step hydrothermal method. The composite structure is characterized by X‐ray diffraction, transmission electron microscopy, scanning electron microscopy, X‐ray photoelectron spectroscopy, and UV‐visible diffuse reflection spectroscopy. Under visible light irradiation, the photocatalytic activity of the sample is evaluated by degradation of methyl orange. The photoelectric chemical performance of the CdS nanoparticles modified by Ag2S is closely related to the ratio of Cd/Ag cation. The experimental results show that the sample ACS‐2 (CdS‐Ag2S = 1:1) composite has higher charge transfer/separation efficiency and longer carrier life. The degradation efficiency reaches 74.4% within 30 min, and the degradation rate constant is 0.047 min−1. After four cycles, the degradation efficiency of the catalyst only decreases slightly, indicating that the CdS/Ag2S catalyst has good stability and repeatability. Meanwhile, the study of the photocatalytic mechanism shows that •O1− is the primary active substance in the catalytic process, and h+ and •OH play a secondary role. This work provides a great significance for constructing efficient Ag2S‐based heterojunction photocatalyst systems.
Health‐related quality of life in patients with chronic orofacial pain compared with other chronic pain patients
Authors: Tanner Johanna , Teerijoki‐Oksa Tuija , Kautiainen Hannu , Vartiainen Pekka , Kalso Eija , Forssell Heli 
Published: March 2022

AbstractBackgroundHealth‐related quality of life (HRQoL) of orofacial pain patients is lower than that of the general population and impaired in multiple dimensions. The aim of the present study was to investigate HRQoL of orofacial pain patients in comparison with patients suffering from other chronic pain disorders.Materials and MethodsOne hundred and fifty‐one tertiary care facial pain patients (mean age, 50 years; standard deviation [SD], 15; 119 females), were compared with 312 other non‐cancer chronic pain patients (mean age, 46 years; SD, 13; 204 women), recruited from three multidisciplinary pain clinics in Finland. The groups were compared using the 15D, and pain‐related measures such as pain interference, pain acceptance, anxiety, depression, and sleep. Statistical comparisons between groups were done using t test, χ2 test, or analysis of covariance. Multivariate linear regression analysis was used to study whether pain‐related aspects influencing HRQoL are similar between the patient groups.ResultsThe 15D score was significantly higher in facial pain patients (0.823; SD, 0.114) indicating better HRQoL in comparison with other chronic pain patients (0.732; SD, 0.107) (p < .001). The 15D profiles of studied populations resembled each other but orofacial pain patients showed significantly higher scores for most individual 15D dimensions. Dimensions regarding discomfort and symptoms and sleep were most affected in both groups. Orofacial pain patients showed less psychosocial disability and better acceptance of their pain. Pain acceptance was a weaker explanatory factor of HRQoL in orofacial pain patients.ConclusionCompared to other non‐cancer chronic pain, chronic pain in the orofacial area causes less impairment in HRQoL. Orofacial pain patients showed less psychosocial disability and better pain acceptance.
Two case reports using a proposed oral risk assessment tool for older people near the end of life
Authors: Tanaka Kumi , Kikutani Takeshi , Tohara Takashi , Sato Shiho , Ichikawa Yoko , Takahashi Noriaki , Tamura Fumiyo 
Published: March 2022

AbstractObjectivesWe developed a prototype technique that expresses the need for intervention and the effectiveness of the treatment when “not being at risk of injury to the oral cavity or to general health” due to the presence of teeth or prostheses is taken as the desired outcome of dental treatment for older people near the end of life. The objective of this study was to use the prototype risk assessment matrix to identify the risk for each patient according to their course and show the effectiveness of treatment.Material and MethodsWe produced a prototype Dental Risk Map (Dental R‐map) based on the risk map method of risk management. Risk is classified into three levels according to the level of tolerability: (A) Risk for which watchful waiting should be included among measures to be considered; (B) risk for which intervention should be considered; or (C) risk requiring urgent intervention.ResultsWe report the application of this technique to two men in their 80s. Both were assessed as risk tolerability Level C, requiring immediate intervention. Dental treatment eliminated this risk in one and reduced it to Level B in the other.ConclusionsWe developed the prototype Dental R‐map to identify oral risks and indicate the need for intervention to address these risks and the effectiveness of treatment for older people near the end of life. We used the Dental R‐map for two patients and successfully avoided oral risks that might cause physical injury in both cases until their deaths.
Testing the stakeholder pressure, relative advantage, top management commitment and green human resource management linkage
Authors: Yong Jing Yi , Yusliza Mohd Yusoff , Ramayah Thurasamy , Seles Bruno Michel Roman Pais 
Published: March 2022

AbstractScholars have acknowledged the importance of green human resource management (HRM). Green HRM has been considered a vital mechanism for companies to move towards a sustainable organisation. However, the factors that drive green HRM have not been thoroughly investigated. This study investigated how green HRM interacts with the linkages among relative advantage, stakeholder pressure, and top management commitment based on the Stakeholder Theory and Resource‐based view theory. Data were collected from 112 large manufacturing firms using a survey. Partial least squares modelling was used to test the hypotheses in the research. All hypotheses were accepted except for relative advantage concerning green analysis and description of job positions, green recruitment and green rewards. Overall, it offers guidelines for decision makers on how to emphasise these factors in organisations and subsequently create a culture of environmentally friendly organisations particularly from the perspective green HRM.
A new seven‐level ANPC inverter structure with semiconductor device reduction
Authors: Siddique Marif Daula , Husain Mohammed Aslam , Wasiq Mohammad , Babu Thanikanti Sudhakar , Mekhilef Saad 
Published: March 2022

AbstractAn active neutral point clamped‐type multilevel inverter (ANPC‐MLI) with self‐voltage balancing capability is being suggested for this study. A new switched capacitor cell with eight switches is used for seven‐level generation in the proposed topology. The topology proposed has decreased the power element count with the ability to self‐balancing of capacitor voltages and boosting ability. The distinguishing characteristics of the proposed topology are emphasized and compared with other recent 7L‐SCMLI topologies. Experimental testing on a prototype hardware is conducted to validate the feasibility of the proposed topology.
Comorbidities present in hidradenitis suppurativa
Authors: Stokes Madison M. , Holahan Heather M. 
Published: March 2022

AbstractHidradenitis suppurativa (HS) is characterized by a chronic, inflammatory cascade that occurs within the apocrine glands and produces inflammatory papules and nodules, abscesses, and scarred, fistulizing sinus tracts. Despite evidence that patients with HS have a two‐fold greater comorbidity burden in comparison to both psoriasis patients and the unaffected, healthy population; the identification of risk factors and the spectrum of co‐existent medical illnesses have not been fully characterized. Recent data has elucidated increased prevalence of several cutaneous, psychologic, gastrointestinal, musculoskeletal, endocrine, conditions in patients with HS. Treatment modalities can be optimized based on shared cytokine profiles and immune dysregulation. Screening guidelines have been recommended based on prevalence, in order to provide better health outcomes for these patients.
Linking genetic diversity and species diversity through plant–soil feedback
Authors: Bolin Lana G. , Lau Jennifer A. 
Published: March 2022

AbstractGenetic diversity and species diversity are typically studied in isolation despite theory showing they likely influence one another. Here, we used simplified communities of one or two populations of one or two species to test whether linkages between genetic and species diversity can be mediated by interactions between plants and their soil microbiota, or microbe‐mediated plant–soil feedback (PSF). Interspecific PSF promotes the maintenance of species diversity when plants grow better with heterospecific soil microbes than with conspecific microbes. Similarly, intraspecific PSF promotes the maintenance of genetic diversity when plants grow better with heterogenotypic than with congenotypic microbes. In a two‐phase greenhouse experiment, we conditioned the soil microbial community with pairs of plants that were either two individuals of the same species (lower species diversity) or one individual of each of two species (higher species diversity), and with pairs of plants that were either two individuals from the same population (lower genetic diversity) or one individual from each of two populations (higher genetic diversity). We then tested the effects of these microbial communities on plant growth in a second phase. We found that higher genetic diversity reduced the ability of interspecific PSF to promote plant species diversity, and for one of our two study species, higher species diversity reduced the ability of intraspecific PSF to promote plant genetic diversity. If these patterns occur in more diverse communities, then our results suggest that PSF may dampen the negative effects of diversity loss by promoting diversity at other levels of biological organization.