bluuebunny/crossref_metadata_2025_split huggingface dataset:
When yeast cells change their mind: cell cycle “Start” is reversible under starvation
Authors: Irvali Deniz , Schlottmann Fabian P , Muralidhara Prathibha , Nadelson Iliya , Kleemann Katja , Wood N Ezgi , Doncic Andreas , Ewald Jennifer C 
Published: November 2022

AbstractEukaryotic cells decide in late G1 phase of the cell cycle whether to commit to another round of division. This point of cell cycle commitment is termed “Restriction Point” in mammals and “Start” in the budding yeastSaccharomyces cerevisiae. At Start, yeast cells integrate multiple signals such as pheromones and nutrients, and will not pass Start if nutrients are lacking. However, how cells respond to nutrient depletionafterthe Start decision remains poorly understood. Here, we analyze how post‐Start cells respond to nutrient depletion, by monitoring Whi5, the cell cycle inhibitor whose export from the nucleus determines Start. Surprisingly, we find that cells that have passed Start canre‐import Whi5 into the nucleus. In these cells, the positive feedback loop activating G1/S transcription is interrupted, and the Whi5 repressor re‐binds DNA. Cells which re‐import Whi5 become again sensitive to mating pheromone, like pre‐Start cells, and CDK activation can occur a second time upon replenishment of nutrients. These results demonstrate that upon starvation, the commitment decision at Start can be reversed. We therefore propose that cell cycle commitment in yeast is a multi‐step process, similar to what has been suggested for mammalian cells.
Batik Sumber Ide Ratu Kalinyamat dan Ornamen Masjid Mantingan Jepara
Authors: Fadillah Icha Zulita , Naam Muh Fakhrihun 
Published: November 2022

Ratu Kalinyamat sebagai tokoh wanita yang inspiratif dan fenomenal di Jepara dan peninggalan bangunan sejarah berupa ornamen yang ada di Masjid Mantingan menjadi ide dasar terciptanya karya batik tulis berupa jarik. Penelitian ini bertujuan untuk mengetahui proses penciptaan motif batik dan mendeskripsikan hasil karya batik dengan sumber ide dari Ratu Kalinyamat dengan kereta kencana dan ornamen masjid makam Mantingan Jepara. Metode yang digunakan dalam penelitian ini adalah metode penelitian Research and Development (RnD). Teknik pengumpulan data dengan observasi, wawancara dengan juru kunci dan expert judgement, dan dokumentasi. Teknik analisis datanya menggunakan metode kualitatif deskriptif meliputi reduksi data dari narasumber dan expert judgement, display data berupa deskripsi atau narasi karya, kesimpulan atau verifikasi. Hasil penelitian karya batik berjudul “Sang Ratu dan Kereta Kencana Penikmat Senja” pada bahan katun primissima dengan teknik batik tulis yang terdiri tahap mencuci kain, molani, nyanting, nemboki, nyolet, nglorod, dan pengemasan. Teknik pewarnaan colet menggunakan pewarna remasol dan fiksasi waterglass, karya batik dideskripsikan berdasarkan unsur dan prinsip desain yang meliputi aspek estetika , aspek bahan, aspek fungsional, aspek kualitas, dan aspek simbolik.
The apudessive in Lithuanian
Authors: Petit Daniel 
Published: November 2022

The paper describes the rise of the apudessive preposition pàs in Lithuanian. The apudessive meaning (‘at someone’s home’) was rare in Old Lithuanian, where pàs denoted spatial proximity in competition with priẽ. The preposition pàs underwent a multi-stage evolution [behind] > [adessive] (first only directional) > [adessive] (both directional and positional) > [apudessive] (both directional and positional).
FUNDAMENTOS HIPOTÉTICOS PARA INVESTIGAR LA CRISIS ECONÓMICA
Authors: Reuben Soto Sergio 
Published: November 2022

El artículo pretende integrar los desarrollos teóricos en el campo de los mercados imperfectos y monopólicos, y el funcionamiento de la firma en tales condiciones, con las teorías de la distribución del ingreso; particularmente entre los grandes agregados macroeconómicos del capital y el trabajo. Formulando así, hipótesis de trabajo desde una perspectiva integral, para enfocar el rompimiento del proceso de acumulación de capital expresado en la crisis económica actual.
STATISTICIAN’S NEW ROLE AS A DETECTIVE – TESTING DATA FOR FRAUD
Authors: Ely Kossovsky Alex 
Published: November 2022

El objetivo de este trabajo es proporcionar al estadístico con un método para la difícil tarea de decidir si un determinado conjunto de datos podría haber sido inventado en forma fraudulenta o en aparente autenticidad. Esto no se hace mediante el examen de los números en sí, pero, sorprendentemente, se hace investigando el lenguaje digital utilizado en escribir esos números! Lo que las letras son para las palabras, los dígitos son para los números. La técnica se basa en la Ley de Benford, una ley estadística que se refiere a la consistencia y predictibilidad de las proporciones relativas a los dígitos que ocurren en los datos típicos de la vida real, estableciendo que dígitos bajos son mucho más frecuentes que los dígitos altos. La ley es extremadamente útil como una herramienta para detectar el fraude, especialmente el fraude fiscal, ya que los estafadores tienden a inventar números donde los dígitos tienen aproximadamente las mismas proporciones, debido a la intuición equivocada de que todos los dígitos aparecen en los datos con igualdad de oportunidades. Al comparar la distribución teórica de Benford con la distribución real de dígitos de los datos de la contabilidad de las empresas, el estadístico puede fácilmente descubrir el fraude en relación con datos falsos o inventados. Estas pruebas forenses digitales son ahora los procedimientos habituales en los departamentos de los ingresos fiscales de la mayoría de los gobiernos de todo el mundo, así como en la contabilidad de las grandes compañías de auditoría.
ESTRATEGIAS PARA LA CREACIÓN DE NUEVAS EMPRESAS, UN ENFOQUE SOCIOCULTURAL O INSTITUCIONAL
Authors: Chávez-Jiménez Enore Adriana , Vargas-Hernández, M. B. A.; Ph.D José G. 
Published: November 2022

El presente trabajo tiene la finalidad de recapitular las principales teorías desde un enfoque sociocultural o institucional que fomentan la creación de nuevas empresas. Dado este contexto, se planteó la importancia del estudio teórico de los factores que influyen para tomar decisiones en el desarrollo de nuevas empresas y cómo afecta el entorno en el cual se desenvuelven los mismos empresarios. El método de investigación empleado es la revisión de la literatura existente mediante el análisis de las principales teorías que intervienen en la creación de empresas, enfatizándose en el enfoque sociocultural. El análisis concluye profundizando en cómo la actividad de entrepreneurship ha fomentado la creación de empresas, siendo un factor importante en el desarrollo económico del país.
DAMP-mediated inflammation and regulated cell death in immunoinflammatory rheumatic diseases
Authors: Saidov M. Z. 
Published: November 2022

The state of autoreactivity of innate immunity dominates in the pathogenesis of immunoinflammatory rheumatic diseases, inducing non-infectious “sterile” inflammation. The distinctive properties of this inflammation include multiorgan affection and recurrent clinical course. The extracellular and intracellular “danger signals” called DAMPs, seem to be a key factor in progression of the inflammatory events. These factors are released by the loose fibrous connective tissue in the course of main substance disorganization, as well as regulated and accidental local cell death. In immune/inflammatory rheumatic diseases, the DAMP-induced patterns of regulated cell death include autophagy, apoptosis, necroptosis, pyroptosis and netosis. Membrane and cytosolic PRR receptors, interacting with DAMPs, promote these DAMP-induced forms of regulated cell death. At the same time, the DAMP-induced modes of regulated cell death are often combined with simultaneous reaction of PRR receptors to the pathogens that preexist in dead cells. TLR-DAMP interaction activates similar signaling pathways, adaptive molecules, transcription factors, forming the same pro-inflammatory inflammasomes as with TLR-PAMP interaction. In these processes, the antigen-presenting function of dendritic cells is expressed to the maximal extent. Given the important role of infections as etiological factors in immunoinflammatory rheumatic diseases, these processes may be the key factor inducing the phenomenon of antigenic cross-presentation. Interactions of DAMPs with PRR receptors of innate immunity cells cause the formation of a DAMP-mediated vicious circle. At the same time, increased levels of proinflammatory DAMPs, both in situ and in systemic circulation, leads, via the PRR-DAMP interactions, to incresing number of cells prone to regulated cell death and to even more pronounced tissue damage. In turn, these processes significantly increase the levels of pro-inflammatory DAMPs in tissues, thus causing progression of “sterile” inflammation to immunoinflammatory rheumatic diseases. The signaling pathways, adaptive molecules, transcription factors, and pro-inflammatory inflammasomes have been identified in all types of regulated cell death induced by PRR-DAMP interaction. The available research results allow us to determine appropriate targets which may be subjected to pharmacological correction. In this respect, significant progress has been made in search for medicinal tools of regulating inflammation in SLE, RA, Sjogren’s syndrome, SSD, etc. Of sufficient importance are both evaluation of serum DAMP levels as diagnostic and prognostic biomarkers, along with their determination for assessing treatment efficiency in immunoinflammatory rheumatic diseases.
Features of post-vaccination humoral immune response in the persons who underwent COVID-19 of various severity
Authors: Ivanova I. A. , Filippenko A. V. , Trufanova A. A. , Omelchenko N. D. , Chemisova O. S. , Noskov A. K. 
Published: November 2022

The studies on humoral immune response in the individuals who have undergone COVID-19 and vaccinated with anti-COVID vaccines allows us to assess the development of “hybrid” immunity, which contributes to understanding the mechanisms of its formation from the effector phase to the step of immunological memory. We assessed the relative and absolute contents of B cell populations and subpopulations, development of humoral immunity in the patients who suffered with COVID-19 of varying severity being thereafter vaccinated with “KoviVak” and “Sputnik V”. The study involved volunteers (age 47.3±14.5 years) who beared COVID-19 asymptomatically (n = 32), at moderate severity (n = 21), or had severe form of the disease (n = 12), then being vaccinated with “KoviVak” and “Sputnik V” 6-9 months after their recovery. The groups of vaccinated persons consisted of those who beared severe disease being vaccinated with “KoviVak” (n = 6) or “Sputnik V” (n = 6); moderate cases, vaccinated with “KoviVak” (n = 10) and “Sputnik V” (n = 11); asymptomatic cases vaccinated with “KoviVak” (n = 10) and “Sputnik V” (n = 22). We have determined relative and absolute numbers of B lymphocytes (CD45+CD19+), B1 lymphocytes (CD45+CD5+CD19-CD27-), B2 lymphocytes (CD45+CD19+CD5-CD27-), total population of memory B cells (CD45+CD19+CD5-CD27+), non-switched (CD45+CD19+IgD+CD27+), and switched (CD45+CD19+IgD-CD27+) memory B cells; mature naive B lymphocytes (CD45+CD19+CD27-IgD+), plasmoblasts (CD45+CD19+CD38+++IgD-CD27+), as well as presence of IgG to S(RBD)-SARS-CoV-2 protein.We have found that the humoral immunity among survivors of COVID-19 of varying severity is expressed for up to nine months. The largest number of volunteers who raised antibodies to SARS-CoV-2 S-protein was registered in the group of seriously ill patients. As soon as 1 month after “Sputnik V” vaccination and until the end of the observation, all the examined subjects in this group became seropositive. 4-5 months after injection of this vaccine, specific immunoglobulins were present in all patients who had asymptomatic or average-severity infection. All volunteers who received “KoviVak” had antibodies to the COVID-19 viral S protein from the beginning to the end of the study. Vaccination, especially with “KoviVak”, contributed to the highest increase, both in relative and absolute numbers of memory B lymphocytes in asymptomatic patients. Less pronounced changes in the content of B lymphocytes in COVID-19 patients who had severe and moderate clinical course may be associated with higher levels of these cells prior to injection of the vaccines. A positive correlation was found between the number of memory B cells and presence of immunoglobulins to the S protein SARS-CoV-2 in all examined patients.
Subpopulation composition of peripheral blood lymphocytes in COVID-19
Authors: Svirshchevskaya E. V. , Konovalova M. V. , Sadykov V. F. , Pyregov A. V. , Poltavtseva R. A. 
Published: November 2022

The pathogenesis of severe coronavirus infection COVID-19 is associated with activation of immune system, cytokine storm, impaired blood clotting, microvascular thrombosis, organ ischemia and multiple organ dysfunction syndrome. The role of various lymphocyte subpopulations in COVID-19 is still debated. The aim of our study was to analyze the subpopulational profile of peripheral blood lymphocytes in COVID-19 patients as compared with healthy donors.The study included 20 COVID-19 patients (11 males and 9 females,) and 26 healthy donors. Average age of the patients was 52 and 56 years, respectively. Clinical examinations were performed by standard laboratory methods. Peripheral blood lymphocytes were isolated in the Ficoll gradient. The cells were stained with antibodies to specific antigens of main lymphocyte populations, endothelial cells, and apoptotic cell markers. The analysis was performed by flow cytometry. The results showed that all patients had elevated C-reactive protein (14- to 35-fold), ferritin (1.2- to 13-fold), D-dimers (1.2- to 90-fold). 55% of men had a decrease in the absolute number of lymphocytes, in women this index was at the low normal limit. Cytometric analysis showed that, among peripheral blood lymphocytes, the proportion of functional cells expressing the CD45 marker ranged from 2 to 12% in 70% of patients, as compared with 80-99% among the donors. The proportion of CD45+ lymphocytes significantly correlated with the level of hemoglobin, but not with the levels of inflammatory biochemical markers. Among the functional lymphocytes of patients, there was a decrease in the proportion of CD3+, CD4+, CD8+T cells, increased proportion of natural killer CD56+ and the apoptotic (AnnexinV+) cell contents, but the proportion of CD19 and HLA-DR+B cells was not changed. Analysis of the lymphocyte (LC) subpopulations that did not express CD45 marker showed that this fraction contained different lymphocyte subsets with reduced expression of CD4, CD8, CD19, CD56 etc. in the blood of patients and donors. Higher percentage of endothelial cells expressing CD62P marker made the difference between patients and donors.Laboratory determination of lymphocyte subsets in blood samples of COVID-19 patients does not reflect the real severity pattern of the disease, thus requiring studies of the CD45-expressing functional cell populations.
Cricotracheal resection: a rare procedure in adults
Authors: Luna Ortiz Kuauhyama , Ochoa Cesar O. Cabrera , Ramon Luis C. Zacarias , Peteul Zelik Luna , Ortega Dorian Y. García 
Published: November 2022

<p>Benign or malignant tumors originating in the cricotracheal region (cricoid cartilage and first tracheal ring) are considered rare events in adult patients. Although there are several treatment options for benign tumors, cricotracheal resection remains the gold standard treatment for malignant tumors. The objective of the present study is to describe the cases that have been treated at our institutions. We selected five cases from a database of 800 clinical records. Three cases were treated at the national cancer institute, Mexico, and two in other institutions. All cases were treated by the same surgeon. Out of four women and one man, with a median age of 52 years, there were two cases of adenoid cystic carcinoma, two of idiopathic stenosis, and one of hemangiopericytoma. All underwent cricotracheal resection with laryngotracheal anastomosis and are still alive. Stenosis or primary tumors of the cricotracheal region can be initially treated with endoscopy. However, cricotracheal resection remains the gold standard treatment as it is a safe surgical procedure with minimal and acceptable sequelae. It also improves disease-free period, overall survival, and quality of life, albeit with a low and acceptable morbidity rate.</p><p> </p>
Uji Kemampuan Adsorpsi Komposit Keratin Bulu Itik-Polietilena Terhadap Ion Besi(III)
Authors: Fauzy Oktavia Hesti , Santoso Uripto Trisno , Utami Umi Baroroh Lili 
Published: November 2022

Research on the adsorption of iron(III) ion using an adsorbent from duck feather-polyethylene composite has been studied. This study aimed to determine the optimum pH conditions and the optimum contact time required in the iron(III) ion adsorption process. Optimum pH and contact time are then measured using AAS to determine the amount of iron(III) ion adsorbed with the duck feather-polyethylene composite adsorbent. The determination of the optimum pH was carried out with pH variations which are 2, 3, 4, 5, 6, 7, and 8, while determination of the optimum contact time was carried out with contact time variations which are 40, 60, 80, 100, 120, 140, and 160 minutes. The result of this research showed that optimum conditions for iron(III) ion adsorption at pH 6 and contact time at 80 minutes, which each adsorption capacity are 68.33% and 79.78%.
Acetyl-11-keto-β-boswellic acid Restrains Inflammation and Extracellular Matrix Degradation of Osteoarthritis via Suppression of NF-κB Pathway
Authors: Zhou Jing , Han Zeyu , Li Xueyan , Shao Zhiqiang , Qian Yinhua , Bai Lang , Han Qibin , Zhang Xiaoyu , Chen Qi , Gao Maofeng , Xue Yi , Geng Dechun , Yang Xing , Hao Yuefeng 
Published: November 2022

Abstract
Background: Mechanical stress along with inflammation play causative roles in the development of osteoarthritis (OA), which decreases the quality of life and causes economic loss. Inflammation and extracellular matrix (ECM) degradation have been identified as key factors in the development of OA. As the main active component in frankincense, acetyl-11-keto-β-boswellic acid (AKBA) has been shown to have positive effects on inflammation. However, the effects of AKBA in cartilage inflammation and ECM degradation are currently elusive.
Methods: We demonstrated the role of inflammation and ECM degradation in the pathogenesis of OA and determined the protective effect of AKBA on both Hulth-Telhagrat OA model and lipopolysaccharide (LPS)-induced rat chondrocytes.
Results: We found increased inflammatory expression and decreased ECM expression in OA model cartilage and LPS-induced chondrocytes. Meanwhile, the protective effect of AKBA and its inhibitory effects on inflammation as well as ECM-related markers were also observed in the rat Hulth-Telhag model. Furthermore, activation of NF-κB attenuated nuclear p65 protein levels in chondrocytes upon LPS stimulation. In addition, AKBA was found to subsequently reversed the LPS-induced activation of NF- κB signal and inflammation-related ECM degradation in chondrocytes.
Conclusions: Suppression of NF-κB pathway activation by AKBA restrains OA development via inhibition of inflammation and ECM degradation. AKBA is a promising therapeutic agent for the treatment of OA.
Identification of stressors and quantification of stress among veterinary students in India using a cross- sectional questionnaire survey
Authors: Grakh Kushal , Jadhav Vijay Jayawant , Panwar Diksha , Khurana Rajesh , Bangar Yogesh Chanderkant , Yadav Dheeraj 
Published: November 2022

Abstract
Veterinary education, being a rigorous professional training programme, exposes students to significant academic and non-academic pressures. Identifying the stressors and evaluating stress levels among veterinary students can help with the development of coping techniques to protect students' mental health. A 44-item based cross-sectional questionnaire survey was prepared and disseminated among veterinary students in India with the goal of identifying the stressors responsible, measuring the amount of stress, and relating stress to characteristics like as gender and family income. The data from the questionnaire was evaluated using a variety of statistical factors. The survey had a high level of internal consistency. More than 95% of pupils were found to be stressed, with levels ranging from moderate to severe. Academic stressors were the primary cause of increased overall stress. In comparison to male students, female students reported higher levels of overall stress, academic stress, and intrapersonal and interpersonal stress. Students from lower-income families experienced increased overall stress as well as stress connected to family expectations. Gender, family income, academic stressors, intrapersonal, interpersonal, and career-related stressors, and social activities-related stressors all positively predicted overall stress among students. These factors should be given special consideration when developing any stress-reduction or stress-reduction strategies for Indian veterinary students. To the best of our knowledge, this is the first study in India to identify stressors and quantify stress among veterinary students.
An improved probability-based discrete particle swarm optimization algorithm for solving the product portfolio planning problem
Authors: Liu Xiaojie , Li An-Da 
Published: November 2022

Abstract
Product portfolio planning (PPP) is one of the most critical decisions for companies to gain an edge in the competitive market. It seeks for the optimal combination of products and attribute levels offered for customers in the target market, which is an NP-hard combinatorial optimization problem. In this paper, we propose a probability-based discrete particle swarm optimization (PDPSO) algorithm to solve the PPP problem. In PDPSO, the particle is encoded as discrete values, which can be straightforwardly used to represent the product portfolio with discrete attributes. PDPSO adopts a probability-based mechanism to update particles. Specifically, a probability vector is used to decide the probability of three search behaviors, i.e., learning from the personal best position, global best position, or random search. In experiments, we have compared the search performance of PDPSO with that of a genetic algorithm (GA) and a simulated annealing (SA) algorithm on generated PPP problem cases with different sizes. The results indicate that PDPSO obtains significantly better optimization results than GA and SA in most cases and obtains desirable/near-optimal solutions on various PPP problem cases. A case study of notebook computer portfolio planning is also presented to illustrate the efficiency and effectiveness of PDPSO.