bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Recent Revival of Western Disturbances Govern the Karakoram Anomaly?
Authors: Javed Aaquib , Kumar Pankaj , Hodges Kevin I. , Sein Dmitry V. , Dubey Aditya K. , Tiwari Gaurav 
Published: April 2022

Abstract
The global retreat in glaciers is considered to be one of the critical indicators of climate change. However, the glaciers of the Karakoram (KR) region of the Karakoram–Himalayas (KH) stand out because of their divergent response, displaying a surge as opposed to glaciers in other regions. This phenomenon is known as the “Karakoram anomaly.” Although many factors control the establishment and sustenance of the anomaly, the present study establishes winter precipitation associated with western disturbances (WDs) over the KH as one of the key drivers behind its emergence. To examine the role of WDs, a tracking algorithm is applied to 39 seasons (November–March) for three separate (ERA5, MERRA-2, and NCEP-CFSR/CFSv2) reanalysis datasets. The associated reanalysis ensemble statistics of WD properties produced in terms of their intensity, precipitation/snowfall volumes, and wind speed suggest a revival in recent years over the core-anomaly regions. However, the frequency has remained steady. The Karakoram has witnessed a rise of ∼10% in precipitation intensity associated with WDs in recent decades. The high percentage of snowfall received by the Karakoram (∼65%) from WDs relative to the total seasonal snowfall suggests a crucial role in modulating the regional mass-balance anomaly. Simultaneously, the amount of snowfall from non-WD sources in the Karakoram has had a statistically significant decline of ∼17% in recent decades, coinciding with the anomaly period. The enhanced intensity of WDs is found to be associated with changes in increased baroclinic instability and a shift of the subtropical westerly jet mean latitudinal position.
Inferior Vena Cava Ligation and Pancreaticoduodenectomy in a Patient With Penetrating Abdominal Trauma
Authors: Williams Eric M. , Croft Chasen A. , Taylor Jessica E. 
Published: April 2022

IntroductionInjury to the inferior vena cava (IVC) is often fatal. Pancreaticoduodenectomy for trauma is also rare. This case describes a patient who underwent both procedures.Case PresentationA 30-year-old male presented status post gunshot to the abdomen. He was taken to the operating room and found to have 6 cm defect in the IVC, which was ligated. Despite resuscitation, the patient required emergent return to the OR where bleeding from the pancreaticoduodenal artery was noted in addition to injuries in the stomach, duodenum, and pancreas. He subsequently underwent a pancreaticoduodenectomy. He was discharged after a month-long hospital stay.ConclusionsThis case demonstrates that IVC ligation is a form of damage of control surgery. Pancreaticoduodenectomy is rarely performed during the index operation for trauma patients. Patient with injuries to the pancreaticoduodenal complex can be life-threatening if not rapidly controlled. This patient is a rare example of someone who survived two morbid trauma surgery interventions.
Prognostic Impact of the Preoperative Systemic Inflammation Score in Patients With Pancreatic Ductal Adenocarcinoma
Authors: Iguchi Tomohiro , Iseda Norifumi , Hirose Kosuke , Itoh Shinji , Harada Noboru , Ninomiya Mizuki , Sugimachi Keishi , Honboh Takuya , Maeda Takashi , Sadanaga Noriaki , Matsuura Hiroshi 
Published: April 2022

Backgroud The systemic inflammation score (SIS), which is based on the preoperative lymphocyte-to-monocyte ratio (LMR) and serum albumin (Alb) level, is a prognostic indicator for several cancer types. However, the prognostic significance of the SIS in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Methods Seventy-eight patients who underwent radical surgery for PDAC were categorized as follows: SIS 0 (LMR ≥3.51 and Alb ≥4.0 g/dl), n = 26; SIS 1 (LMR <3.51 or Alb <4.0 g/dl), n = 29 and SIS 2 (LMR <3.51 and Alb <4.0 g/dl), n=23. Results The tumour size sequentially increased in SIS 0, 1 and 2 groups. A higher SIS was associated with increased vascular invasion, perineural invasion and surgical margin positivity rate. Recurrence-free survival (RFS) rates between the SIS 1 and 2 groups showed no significant difference However, patients of the SIS 1 and 2 groups had poorer outcomes than those of the SIS 0 group for RFS. Overall survival (OS) rates between the SIS 1 and 2 groups also showed no significant difference. However, patients of the SIS 1 and 2 groups had poorer outcomes than those of the SIS 0 group for OS. The SIS was an independent prognostic factor for RFS and OS. Discussion The SIS is a simplified prognostic factor for patients with PDAC.
A Cost-Utility Analysis of the Use of Closed-Incision Negative Pressure System in Vascular Surgery Groin Incisions
Authors: Bloom Joshua A. , Tian Tina , Homsy Christopher , Singhal Dhruv , Salehi Payam , Chatterjee Abhishek 
Published: April 2022

Objective Closed-incision negative pressure therapy (CINPT) with the Prevena system has been used and clinically evaluated in high-risk groin incisions to reduce the risk of postoperative complications. We performed a cost-effectiveness analysis evaluating CINPT in femoral-popliteal bypass with prosthetic graft. Methods A literature review looking at prospective randomized trials determined the probabilities and outcomes for femoral-popliteal bypass with and without CINPT. Reported utility scores were used to estimate the quality adjusted life years (QALYs) associated with a successful procedure and postoperative complications. Medicare current procedure terminology and diagnosis-related group codes were used to assess the costs for a successful surgery and associated complications. A decision analysis tree was constructed with rollback analysis to highlight the more cost-effective strategy. An incremental cost-effectiveness ratio (ICER) analysis was performed with a willingness to pay at $50,000. Deterministic and probabilistic sensitivity analyses were performed to validate the robustness of the results, and to accommodate for the uncertainty in the literature. Results Femoral-popliteal bypass with CINPT is less costly ($40,138 vs $41,774) and more effective (6.14 vs 6.13) compared to without CINPT. This resulted in a negative ICER of −234,764.03, which favored CINPT, indicating a dominant strategy. In one-way sensitivity analysis, surgery without CINPT was more cost-effective if the probability of successful surgery falls below 84.9% or if the cost of CINPT exceeds $3139. Monte Carlo analysis showed a confidence of 99.07% that CINPT is more cost-effective. Conclusions Despite the added device cost of CINPT, it is cost-effective in vascular surgical operations using groin incisions.
Replicate and repeat faecal immunochemical tests in symptomatic patients: A systematic review
Authors: Farkas Nicholas G , Fraser Callum G , Maclean William , Jourdan Iain , Rockall Tim , Benton Sally C 
Published: April 2022

Background Faecal Immunochemical tests (FITs) in the assessment of patients presenting with symptoms have generally used a single sample. Little evidence pertains to the use of replicate, where a number of tests are done prior to decision-making or repeat FIT, where additional FIT are performed following clinical decision-making. Overwhelmingly, research has focussed on FIT to help identify colorectal cancer (CRC). The aim of this review is to assess the available literature concerning replicate and repeat FIT in symptomatic patients to help generate consensus and guide future research. Methods The terms ‘faecal immunochemical test’ or ‘FIT’ were combined with ‘multiple’ or ‘repeat’. EMBASE, Medline and PubMed database and other searches were conducted. All papers published in English were included with no exclusion date limits until November 2021. Results Of the 161 initial papers screened, seven were included for review. Qualitative and quantitative FIT outcomes were assessed in the studies. The primary aims of most related to whether replicate FIT increased diagnostic yield of CRC, with colonoscopy used as the reference standard. One publication assessed the impact of a new COVID-adapted pathway on CRC detection. No consensus on replicate FIT was apparent. Some concluded that FITs may help minimise missed CRC diagnoses: others showed no increase in diagnostic yield of CRC. Conclusions Current evidence on replicate and repeat FIT is both minimal and conflicting. FIT is a superb clinical tool, but significant gaps surrounding application remain. Further studies relating to replicate and repeat FIT are required.
The politics of job retention schemes in Britain: The Coronavirus Job Retention Scheme and the Temporary Short Time Working Compensation Scheme
Authors: Wiggan Jay , Grover Chris 
Published: April 2022

The UK Government's introduction of the Coronavirus Job Retention Scheme (CJRS) in March 2020 was pitched as unprecedented. Yet, during the 1970s and 1980s, UK governments also operated wage subsidy job retention schemes. Indeed, despite their professed liberal market orientation, Thatcher's radical right Conservative governments presided over the expansive Temporary Short Time Working Compensation Scheme (TSTWCS) between 1979 and 1984. Drawing upon the work of Gallas (2016) , we contend this embrace of wage subsidy schemes by Conservative governments almost 40 years apart emanate from a class politics focused on securing the subordination of labour. In our analysis, the TSTWCS is understood as a mechanism to dampen disquiet with the early Thatcher Government's project to restore employer dominance. And the CJRS is a mechanism to preserve the labour market relations of domination and exploitation successfully embedded by the Conservatives in the 1980s.
Ideas on Universal Ethics in Mahāyāna Buddhism
Authors: Braarvig Jens 
Published: April 2022

AbstractBuddhism in all its expressions is often characterised as a ‘World Religion’. Thus, in principle, it harbours a universal message transcending any ethnicity and national boundaries, and it may be argued that it is historically the most important common ideology for all of South, East and Central Asia. In its canonical literature and religious thinking, Buddhism presents a number of elements easily characterised as global ethics, with an egalitarian and altruistic tone. As such, with its philosophically grounded virtues and morality, Buddhism can represent a reference point and a multifaceted background for an informed discussion of global ethics. The present paper describes in brief a few topics relevant to such a discussion.
Comparison of clinical outcomes between patellar resurfacing and patellar non-resurfacing in cruciate retaining total knee arthroplasty
Authors: Noh Jung Ho , Kim Nam Yeop , Song Ki Ill 
Published: April 2022

Background It is not established whether patellar resurfacing is better than patellar non-resurfacing during total knee arthroplasty (TKA). This study was to compare the clinical outcomes between groups with patellar resurfacing and non-resurfacing during cruciate retaining (CR) TKA. Methods In this retrospective cohort study, subjects undergoing primary CR TKA for osteoarthritis between 2012 and 2019 were included. Of 500 subjects, 250 had patellar resurfacing (group 1) and 250 had patellar non-resurfacing (group 2) CR TKA. Knee society knee score (KSKS), knee society function score (KSFS), Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scale, Kujala score, anterior knee pain, patellar compression test and range of motion (ROM) of the replaced knee were assessed and compared between the two groups. Results There were no significant differences in KSKS, KSFS, WOMAC scale, Kujala score, prevalence of anterior knee pain and ROM of the replaced knee between the two groups at the last follow-up ( p > .05). Group 2 had more subjects with positive patellar compression test than group 1 at the last follow-up ( p = .010). Conclusions Clinical and functional outcomes of the replaced knee were not different between patellar resurfacing and non-resurfacing groups. Anterior knee pain was significantly reduced after total knee arthroplasty regardless of patellar resurfacing. Level of evidence Retrospective cohort study, Level III.
Balanced Salt Solutions for Critically Ill Patients: Nonplused and Back to Basics
Authors: Kopp Brian J. , Lenney Morgan , Erstad Brian L. 
Published: April 2022

Objectives The purpose of this article is to summarize the results of major randomized controlled trials (RCTs) comparing clinical outcomes of critically ill patients treated with normal saline (NS) or balanced salt solutions (BSSs), address discordant results of these studies, and provide direction for future investigations. Data Sources PubMed (2011 to January 2022) with bibliographies of retrieved articles searched for additional articles. Study Selection and Data Extraction RCTs comparing NS and BSSs in critically ill adult patients. Data Synthesis Recently published large RCTs comparing NS with BSSs in heterogeneous populations of intensive care unit patients did not find significant differences in mortality, despite positive findings in some end points in prior RCTs. However, there were a number of methodologic issues common to the RCTs including: varying study designs and end points, clinician discretion for the majority or all treatments other than the primary intervention fluid, heterogeneous patients with varying levels of acuity, and lack of power to investigate potential subgroup differences. In addition, there were problematic issues related to blinding and use of nonstudy fluids. Relevance to Patient Care and Clinical Practice Intravenous fluids are a mainstay of supportive care for critically ill patients. Similar to the so-called crystalloid-colloid debate, there has been a long-standing debate among critical care clinicians and researchers concerning the preferred crystalloid solution, NS versus one of the available BSSs. Conclusions Despite the recent publication of large multicenter RCTs, the preferred resuscitation fluid, NS or a BSS, for critically ill patients is still open for debate, although the available investigations do provide some direction for clinicians and for future investigations.
Health-Related and Behavioral Factors Associated With Lung Cancer Stage at Diagnosis: Observations From Alberta’s Tomorrow Project
Authors: Aktary Michelle L. , Ghebrial Monica , Wang Qinggang , Shack Lorraine , Robson Paula J. , Kopciuk Karen A. 
Published: April 2022

Background Lung cancer is the leading cause of cancer death in Canada, with stage at diagnosis among the top predictors of lung cancer survival. Identifying factors associated with stage at diagnosis can help reduce lung cancer morbidity and mortality. This study used data from a prospective cohort study of adults living in Alberta, Canada to examine factors associated with lung cancer stage at diagnosis. Methods This cohort study used data from adults aged 35–69 years enrolled in Alberta’s Tomorrow Project. Partial Proportional Odds models were used to examine associations between sociodemographic characteristics and health-related factors and subsequent lung cancer stage at diagnosis. Results A total of 221 participants (88 males and 133 females) developed lung cancer over the study period. Nearly half (48.0%) of lung cancers were diagnosed at a late stage (stage IV), whereas 30.8 % and 21.3% were diagnosed at stage I/II and III, respectively. History of sunburn in the past year was protective against late-stage lung cancer diagnosis (odds ratio (OR) .40, P=.005). In males, a higher number of lifetime prostate specific antigen tests was associated with reduced odds of late-stage lung cancer diagnosis (odds ratio .66, P=.02). Total recreational physical activity was associated with increased odds of late-stage lung cancer diagnosis (OR 1.08, P=.01). Discussion Lung cancer stage at diagnosis remains a crucial determinant of prognosis. This study identified important factors associated with lung cancer stage at diagnosis. Study findings can inform targeted cancer prevention initiatives towards improving early detection of lung cancer and lung cancer survival.
Local damage characteristics of reinforced concrete slabs subjected to hard/deformable projectile impact
Authors: Beppu Masuhiro , Kataoka Shinnosuke , Mori Koki , Ichino Hiroyoshi 
Published: April 2022

This study aims to investigate the local failure mechanism of reinforced concrete slabs subjected to hard and deformable projectile impacts. This is done by conducting impact tests and numerical simulations. In a series of impact tests, a hard/deformable steel projectile (8.3–8.4 kg) collided with a reinforced concrete slab with a thickness of 10–30 cm at an impact velocity of 64–90 m/s, and the impact and reaction forces were measured. The numerical simulation demonstrated that the failure of the reinforced concrete slab was affected by the rigidity of the projectile in terms of the maximum impact force and impulse.
Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol
Authors: Brunet Jennifer , Wurz Amanda , Hussien Julia , Pitman Anne , Conte Ellen , Ennis Julie K. , Herry Christophe L. , Seely Andrew J. E. , Seely Dugald 
Published: April 2022

Background: Following cancer treatment, adults commonly report worsened patient-reported outcomes (PROs) such as anxiety, stress, depression, persistent and upsetting cognitive complaints, unrelenting fatigue, and reduced quality of life. Poorer PROs are associated with disrupted autonomic nervous system functioning as measured by heart rate variability (HRV), both of which have been associated with greater morbidity and mortality. Interventions to improve HRV and PROs among adults following cancer treatment are needed. Yoga therapy holds promise as an intervention to improve HRV and PROs. Therefore, we conducted a single-subject exploratory experimental study to investigate the effects of yoga therapy on HRV and specific PROs (ie, cancer-related fatigue, anxiety, cognitive function, depression, stress, quality of life) in adults treated for cancer. To reduce publication bias, improve reproducibility, and serve as a reference for forthcoming reporting of study results, we present the study protocol for this study herein. Methods: Participants were adults who completed cancer treatment that were recruited from the Ottawa Integrative Cancer Centre. Consenting and eligible participants received one 1:1 yoga therapy session (ie, 1 participant, 1 Yoga Therapist) and 6 weekly group-based yoga therapy sessions (ie, 2-3 participants, 1 Yoga Therapist). Participants completed assessments 7 times: 3 times prior to the program (ie, −6 weeks, −3 weeks, immediately prior to the 1:1 yoga therapy session), immediately following the 1:1 yoga therapy session, prior to the first group-based yoga therapy session, after the last group-based yoga therapy session, and at a 6-week follow-up. Hierarchical linear modeling will be used to test the average effects of the yoga therapy program across participants. Discussion: This study will explore several novel hypotheses, including whether yoga therapy can improve HRV and/or specific PROs among adults treated for cancer acutely (ie, during a 1:1 yoga therapy session) and/or through repeated exposure (ie, after completing 6 weeks of group-based yoga therapy). Although the findings will require confirmation or refutation in future trials, they may provide initial evidence that YT may benefit adults treated for cancer. Trial registration: ISRCTN registry, ISRCTN64763228. Registered on December 12, 2021. This trial was registered retrospectively. URL of trial registry record: https://www.isrctn.com/ISRCTN64763228
Clomid after failed Onco-microsurgical testicular sperm extraction: A case for delaying contralateral surgical sperm retrieval
Authors: Khan Nawal , Yap Tet , Kopeika Julia , Shabbir Majed 
Published: April 2022

Background & Objectives: Onco-microsurgical testicular sperm extraction (Onco-microTESE) allows the microsurgical extraction of testicular sperm from the unaffected regions of the tumour-bearing testis at the time of radical orchidectomy. We report the case of a 36-year-old hypogonadotropic male with a testicular tumour and non-obstructive azoospermia. Method: A left radical orchidectomy was performed with simultaneous onco-microTESE. Although some sperm were found during the procedure, these were unsuitable for cryopreservation due to abnormal morphology. Given his low testosterone level (4.1 nmol/L), contralateral surgical sperm retrieval at the same sitting was not performed. Histology of the affected testicle demonstrated a classical seminoma and ‘Sertoli cell only’ appearance. He was subsequently started on clomiphene citrate. Results: After 9 months of clomiphene citrate, repeat semen analysis showed a total of 2.8 million sperm (1 million/mL), with 80% motility. Four vials of semen were cryopreserved, and this ejaculated sperm was used for in vitro-fertilisation (IVF) with intracytoplasmic sperm injection (ICSI). All six harvested eggs were fertilised. By day 5, there were two top grade blastocysts available, one of which was transferred and another frozen. After 9 months, the couple welcomed the birth of a healthy male infant. Conclusion: To our knowledge, this case is the first to demonstrate the benefit of clomiphene citrate in a patient with testis cancer resulting in a reversal of azoospermia and a subsequent live birth with assisted conception. Level of evidence: Not applicable
Pre-Operative Planning in Complex Deformities and Use of Patient-Specific UNiD™ Instrumentation
Authors: Ou-Yang David , Burger Evalina L. , Kleck Christopher J. 
Published: April 2022

Study Design Review of current literature and authors experience. Objective Pre-operative planning is an integral part of complex spine surgery. With the advent of computer-assisted planning, multiple surgical plans can be evaluated utilizing alignment parameters, and the best plan for individual patients selected. However, the ability to evaluate and measure surgical correction goals intraoperatively are still limited. The use of patient-specific UNiD rods, created based on pre-operative plans, provided an initial tool for implementation of pre-operative plans in the operative setting. Methods A literature review for the use of patient-specific UNiD rods in thoracolumbar spine complex surgery was performed. The articles were selected and reviewed for the initial experience/outcomes of these techniques. Further, the initial experience of the authors at The University of Colorado is described. Results The use of UNiD patient-specific rods, in combination with pre-operative planning has been shown to provide a higher rate of patients with spinopelvic alignment parameters within currently accepted ranges. This includes improvement of sagittal vertical axis (SVA) < 50 mm and pelvic incidence (PI)–lumbar lordosis (LL) = ± 10°. Multiple authors have shown improvement in pelvic tilt to age adjusted values but note continued difficulties in obtaining correction goals. Conclusions The use of pre-operative planning software and UNiD patient-specific rods has been shown to improve surgeon’s ability to achieve spinopelvic alignment parameters, specifically SVA and PI-LL, along with other possible benefits. Further research is needed regarding long-term value of the technology.