bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salivary Proteomics Identifies Transthyretin as a Biomarker of Early Dementia Conversion
Authors: Eldem Ece , Barve Aatmika , Sallin Olivier , Foucras Sandrine , Annoni Jean-Marie , Schmid Adrien W. , Alberi Auber Lavinia 
Published: January 2022

Background: Alzheimer’s disease (AD) remains to date an incurable disease with a long asymptomatic phase. Early diagnosis in peripheral biofluids has emerged as key for identifying subjects at risk and developing therapeutics and preventative approaches. Objective: We apply proteomics discovery to identify salivary diagnostic biomarkers for AD, which are suitable for self-sampling and longitudinal biomonitoring during aging. Methods: 57 participants were recruited for the study and were categorized into Cognitively normal (CNh) ( n = 19), mild cognitive impaired (MCI) ( n = 21), and Alzheimer’s disease (AD) ( n = 17). On a subset of subjects, 3 CNh and 3 mild AD, shot-gun filter aided sample preparation (FASP) proteomics and liquid chromatography mass spectroscopy (LC-MS/MS) was employed in saliva and cerebrospinal fluid (CSF) to identify neural-derived proteins. The protein level of salivary Transthyretin (TTR) was validated using western blot analysis across groups. Results: We found that 19.8% of the proteins in saliva are shared with CSF. When we compared the saliva and CSF proteome, 24 hits were decreased with only one protein expressed more. Among the differentially expressed proteins, TTR with reported function in amyloid misfolding, shows a significant drop in AD samples, confirmed by western blot showing a 0.5-fold reduction in MCI and AD compared to CNh. Conclusion: A reduction in salivary TTR appears with the onset of cognitive symptoms. More in general, the proteomic profiling of saliva shows a plethora of biomarkers worth pursuing as non-invasive hallmarks of dementia in the preclinical stage.
Does Ethnicity Influence Recruitment into Clinical Trials of Parkinson’s Disease?
Authors: Lau Yue Hui , Podlewska Aleksandra , Ocloo Josephine , Gupta Atul , Gonde Christopher , Bloem Bastiaan R. , Chaudhuri K. Ray 
Published: January 2022

Background: Lack of participation of black and minority ethnic communities (BAME) in registered clinical trials is a concern as data emerging from these studies are used to licence new drugs or other interventions, even though findings made in such selected study populations have limited external validity in the aforesaid ethnic groups. Objective: We used Parkinson’s disease (PD), the fastest rising neurodegenerative disorder in the world, as an exemplar condition to test our hypothesis that participants from BAME communities are underrepresented in clinical trials. Methods: A systematic search of clinical trials registered on a Clinicaltrials.gov database which queried for PD with racial distribution data from 2017 to 2021. Results: Out of 266 trials considered, 54 trials were published in peer reviewed journals. Among these, only 23 (42.65%) publications reported data regarding the racial distribution of the participants. Out of these, five studies involved mixed racial participation and two trials included black subjects. Conclusion: We found that inclusion of under-represented BAME groups in recently published clinical trials is low, at only 21.57%, and is not even considered in most studies. Out of the reviewed trials, only 5 (21.75%) studies reported detailed demographic categories with black minorities enrolment. This constitutes a severe under-representation when compared to the proportion of Black or African American in the UK population (3%). Results of this study identified the need for better reporting of racial composition in clinical trials. We strongly recommend that future studies should consider ethnicity and other issues around diversity when designing and implementing the clinical trials, not only in the PD field but also beyond.
COMPARATIVE STUDY OF WOUND COMPLICATIONS IN OBESE PATIENTS V/S NON-OBESE PATIENTS UNDERGOING EMERGENCY ABDOMINAL SURGERY.
Authors: Mehta Smit , Kumar Akhendar , Shah Samir M , Dekhaiya Firdaus A 
Published: January 2022

Background :This is a prospective, comparative, observational study done amongst the obese and non-obese patients who are admitted and undergone emergency abdominal surgery during the duration of one year to compare incidence of complications in both obese and non-obese group of patients.
Objective :Prospective, comparative, observational study amongst the obese and non-obese patients who are undergone emergency abdominal surgery to compare the incidence of complications among them. Methods :All post-operative patients who are admitted in ward of department of general surgery, Sir T general hospital, Bhavnagar during the study duration of 1 year. We had applied aseptic dressings on all the postoperative patients and then divide them into obese and non-obese group according to their BMI and during study time period we will compare the role of obesity in wound complications.
Result :The incidence rate of post-operative complication as fever in obese(80%) & non-obese(35%), hemorrhage/hematoma in obese(15%) & nonobese(0%) , septicemia in obese(45%) & non-obese(15% ) ,atelectasis in obese(25%) & non-obese(0%) , as pneumonitis in obese(25%) & nonobese(0%) , as fistula both groups had 0%, as wound infection in obese(45%) & non-obese(10%) , as seroma in obese(25%) & nonobese(0%) and dehiscence in obese(15%) & non-obese(0%) patients.
Conclusion: The wound complications are significantly associated with obesity in patients undergoing abdominal surgery and incidence of complications are more in obese as compared to in non-obese patients.
Key words: Obese, non-obese, Wound, Complications, emergency abdominal Surgery
Review Bandar Udara Dari Sisi Landside dengan Meninjau Segi Kepuasan Penumpang
Authors: Estikhamah Fithri , Aryaseta Bagas 
Published: January 2022

Bandara dibagi menjadi dua bagian: udara (sisi udara) dan sisi darat (sisi darat). Bangunan terminal menghubungkan infrastruktur sisi udara dan sisi darat bandara . Berdasarkan fitur-fitur ini, bangunan terminal dibagi menjadi empat bagian: akses antarmuka, proses, area penyimpanan, dan sirkulasi internal. Gedung terminal memiliki fasilitas pelayanan seperti tiket penumpang, penanganan barang dagangan (bagasi), ruang tunggu, kantor imigrasi, dan kantor operasional maskapai. Kepuasan pelanggan adalah prioritas utama di semua industri berorientasi layanan. Tak terkecuali industri penerbangan sipil. Lalu lintas udara di dunia yang sangat kompetitif berarti bahwa maskapai yang berbeda bersaing untuk posisi teratas, yang membuat layanan pelanggan menjadi sangat penting. Skytrax merespons dari bandara, yang dilengkapi dan diservis lengkap. Setiap tahun, Skytrax memberikan penghargaan kepada bandara-bandara yang telah memenuhi persyaratan menjadi bandara kelas dunia. Surat ini menargetkan untuk menemukan elemen yang dibutuhkan untuk meningkatkan kepuasan pelanggan. Dalam hal ini, penumpang dan pengunjung di bandara.
“COVID-19 Pandemisi Sürecinde Okulu Yönetmek” Olgusuna İlişkin Okul Yöneticilerinin Metaforik Algıları
Authors: Bozkurt Bayram , Aktaş Halil İbrahim 
Published: January 2022

Bu araştırmanın amacı okul yöneticilerinin COVID-19 pandemisi sürecinde okulu yönetmek olgusuna ilişkin algılarını metaforlar aracılığıyla ortaya koymaktır. Araştırmada nitel araştırma desenlerinden olgu bilim (fenomenoloji) deseni kullanılmıştır. Araştırmanın çalışma grubunu, maksimum çeşitlilik örnekleme yöntemine göre belirlenen ve Gaziantep’te görev yapan 114 okul yöneticisi oluşturmaktadır. Çalışma grubundaki katılımcıların çeşitliliği çalıştıkları okul kademesi, cinsiyet, yaş, eğitim durumu ve kıdem gibi demografik özellikler ile sağlanmıştır. Elde edilen veriler içerik analizine tâbi tutulmuştur. Yapılan analizler sonucunda COVID-19 pandemisi sürecinde okul yönetimi olgusuna ilişkin oluşturulan 114 metafor; krizi yönetmek, belirsizlikle yaşamak, risk altında olmak, sorumluluk taşımak, liderlik yapmak, boşuna çabalamak, değişimi yönetmek, mücadele etmek, keyif almamak, yetki eksikliği ve yoğun iş yükü olmak üzere 11 kategori altında sınıflandırılmıştır. Elde edilen bulgular ve sonuçlar doğrultusunda önerilerde bulunulmuştur.
BAHASA DAN IDENTITAS DALAM STUDENT HIDJO: TINJAUAN SOSIOLOGI SASTRA
Authors: Galuh Sakti Bandini  
Published: January 2022

Abstrak
Dunia sastra Indonesia sebelum kemerdekaan cukup unik. Ditinjau dari segi bahasa, ada dua jenis sastra Indonesia yang beredar di Hindia Belanda, yaitu karya sastra yang menggunakan bahasa Melayu Tinggi dan Bahasa Melayu Pasar. Masing-masing bahasa mewakili ideologi tertentu. Tulisan ini membahas penggunaan bahasa dalam Student Hidjo karya Mas Marco Kartodikromo dan kaittannya dengan identitas, ditinjau dari sudut pandang sosiologi sastra. Dari penelitian ini terlihat bahwa penggunaan bahasa Melayu Rendah yang dicampur bahasa Belanda di dalam Student Hidjo tidak hanya menunjukkan identitas tokoh sebagai intelektualis muda, tapi juga sebagai bentuk perlawanan Mas Marco terhadap kolonialisme.
Kata Kunci: Student Hidjo, Mas Marco, Bahasa, identitas, sosiologi sastra.

Abstract
The world of Indonesian literature before independence was unique. In terms of language, there are two types of Indonesian literature circulating in the Dutch East Indies, literary works that use the High Malay and the Pasar/low Malay. Each language represents a certain ideology. This paper discusses the use of language in Mas Marco Kartodikromo's Student Hidjo and its relation to identity from the sociology of literature. From this research, it can be seen that the use of Low Malay mixed with Dutch in Student Hidjo not only shows the identity of the character as a young intellectual but also as a form of Mas Marco's resistance to colonialism.
Keyword: Student Hidjo, Mas Marco, language, identity, sociology of literature
Leukocyte Telomere Length Shortening Implies Plaque Instability and Major Adverse Cardiovascular Events in Patients With Angiographically Intermediate Lesions
Authors: Zhang Alian , Fan Li , Bao Xiaolu , Xu Zuojun , Yin Zhaofang , Zhuo Yang , Zhang Junfeng , Gu Jun , Chang Alex C. Y. , Fan Yuqi , Wang Changqian 
Published: January 2022

BackgroundTelomere shortening, an indicator of aging, is associated with age-related diseases. This study aims to investigate the association between leukocyte telomere length (LTL) and thin-capped fibroatheromata (TCFA) and the impact of using LTL cutoff to determine the incidence of major adverse cardiovascular events (MACEs) in patients with angiographically intermediate coronary lesions.MethodsThis was a signal-center retrospective study focusing on patients who underwent coronary angiography and optical coherence tomography (OCT). The degree of coronary stenosis was assessed by angiography. The presence of TCFA was determined by OCT imaging. A total of 156 patients with angiographically intermediate coronary lesions were enrolled.ResultsLeukocyte telomere lengths were significantly shorter in the TCFA group compared with non-TCFA group [11.95 (10.56, 15.21) kb vs. 13.81 (12.06, 16.11) kb, p = 0.003]. The short-LTL group and long-LTL group were divided according to the optimal cut-off value which was determined by the receiver operating characteristic (ROC) curve analysis. Logistic regression model revealed that short-LTL was independently associated with TCFA incidence (odds ratio [OR] 4.387, 95% CI: 1.902–10.120, p = 0.001) after adjusting for confounding factors. Over a 24-months follow-up, the MACE incidence among patients with short-LTL was significantly higher than those in the long-LTL group (12.5 vs. 2.0%, p = 0.006 by log-rank test). Multivariable cox regression analysis indicated that short-LTL (hazard ratio [HR] 9.716, 95% CI: 1.995–47.319, p = 0.005) was an independent prognostic factor of MACE incidence in angiographically intermediate coronary lesions patients.ConclusionsShort-LTL was independently associated with the incidence of TCFA and may serve as a prognostic factor for MACE risk on top of conventional risk factors.
Investigating Stress Transfer Between the Tuz Gölü Fault Zone and Hasan Dağ Volcano (Turkey)
Authors: Hedger Emily , Gottsmann Jo 
Published: January 2022

Faulting, magmatism and volcanism are intrinsically linked by plate tectonics. Fault slip imparts stress changes to the surrounding crust and other faults and fractures. Volcano-tectonic hazard assessment in areas with long recurrence intervals of volcanic and tectonic activity requires an assessment of current stress levels. Here we investigate stress transfer between the Akhisar-Kiliç fault segment (AKFS) of the seismically active Tuz Gölü fault zone in the Central Anatolian Volcanic Province and the active Hasan Dağ volcanic complex. Current stress accumulation by protracted gradual slip on the AKFS since its most recent rupture (5.45 ka±0.16 BP) is quantified using the Coulomb Failure Stress change (ΔCFS). We calculate currently accrued ΔCFS magnitudes of between 2.5±0.2 and 15±0.5 MPa on the fault plane for published lower and upper-bound estimates of right-lateral slip rates, respectively. These changes are sufficient to promote failure of the segment. The M5.1 September 20, 2020 earthquake SW of Hasan Dağ occurred in a volume predicted by this study to have undergone fault unclamping by gradual slip along the AKFS. We also show that gradual slip of the AKFS contributes to the progressive unclamping of fractures and transtensional opening of potential magma pathways oriented perpendicularly to the AKFS both above and below Hasan Dağ’s magma reservoir, while pathways oriented parallel to the AKFS are being clamped. Earthquake moment magnitudes of between Mw5.94 and Mw6.76 due to hypothetical partial or complete rupture of the segment exacerbate these trends. The spatial pattern of Coulomb failure stress changes on Hasan Dağ’s magma reservoir is predominantly controlled by the location of rupture relative to the reservoir with the magnitude of the earthquake playing a subordinate role. We explore implications of our findings for the assessment of interconnected seismo-volcanic hazards and associated risks.
PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas
Authors: Zhu Kejing , Cheng Xueting , Wang Shuman , Zhang Hong , Zhang Yu , Wang Xiong , Chen Yonggang , Wu Jinhu 
Published: January 2022

BackgroundProlactinoma is the most common type of pituitary tumors, and its resultant tumor occupying and hormone disturbance greatly damage the health of patients. In this study, we investigated a protein kinase-PDZ Binding Kinase (PBK)/T-LAK Cell-Originated Protein Kinase (TOPK) as a candidate protein regulating prolactin (PRL) secretion and tumor growth of prolactinomas.MethodsDownloaded prolactinoma transcriptome dataset from Gene Expression Omnibus (GEO) database, and screened differentially expressed genes (DEGs) between normal pituitary tissues and prolactinoma tissues. Then, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of DEGs were performed, a protein-protein interaction (PPI) network was constructed and the hub genes were identified. After a literature search, TOPK was presumed as an candidate target regulating the prolactinoma. We found a specific inhibitor of TOPK to investigate its effects on the proliferation, migration, apoptosis and PRL secretion of pituitary tumor cells. Finally, the regulation of TOPK inhibitor on its downstream target-p38 Mitogen Activated Protein Kinase (p38 MAPK) was detected to explore the potential mechanism.ResultsA total of 361 DEGs were identified, and 20 hub genes were screened out. TOPK inhibitor HI-TOPK-032 could suppress the proliferation &amp; migration and induce apoptosis of pituitary tumor cells in vitro, and reduce PRL secretion and tumor growth in vivo. HI-TOPK-032 also inhibited the phosphorylation level of the downstream target p38 MAPK, suggesting that TOPK inhibitors regulate the development of prolactinoma by mediating p38 MAPK.ConclusionOur study of identification and functional validation of TOPK suggests that this candidate can be a promising molecular target for prolactinoma treatment.
Candida Infection as an Early Sign of Subsequent Sjögren's Syndrome: A Population-Based Matched Cohort Study
Authors: Chen Chia-Lun , Chang Fang-Cherng , Hung Yao-Min , Chou Mei-Chia , Yip Hei-Tung , Chang Renin , Wei James Cheng-Chung 
Published: January 2022

BackgroundCandida infection is prevalent in patients with Sjögren's syndrome (SjS), which usually takes years to reach diagnosis. Is the link a two-way street? The role of Candida infection before SjS has not been examined clearly. This study was conducted to provide epidemiological evidence regarding the relationship between the first acquisition of Candida infection and subsequent SjS.MethodsTotally, 23,494 individuals newly diagnosed with Candida infection were enrolled from 2000, to 2012. Controls (N = 93,976) were selected at a 1:4 ratio through propensity score matched (PSM) using the greedy algorithm. Exposure was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes.Main Outcomes and MeasuresSjS was recorded in the Registry for Catastrophic Illness Patients Database (RCIPD). Cox proportional hazard model was used to analyze the association and sensitivity analyses for cross-validation.ResultsOf 117,470 individuals (106,077 [89%] women), 23,494 individuals (20.0%) had Candida infection and 104 individuals (0.1%) developed SjS. The incidence of SjS was higher in the exposed group compared with the controls (1.92 vs. 0. 98 per 10,000 person-years) with adjusted hazard ratio (aHR) 1.90 (95% CI, 1.25–2.87). The aHRs in subgroups of aged 18–30 years, oral candidiasis and depression were 4.30 (95% CI, 1.60–11.55), 4.70 (4.70–13.93) and 6.34 (2.16–18.66). Sensitivity analyses yield consistent results.ConclusionsResidents in Taiwan with Candida infection have higher risk of SjS. For early diagnosis of SjS, clinicians are advised to take Candida infection into account in some situation.
Integrative Genomic Analyses of 1,145 Patient Samples Reveal New Biomarkers in Esophageal Squamous Cell Carcinoma
Authors: Zou Binbin , Guo Dinghe , Kong Pengzhou , Wang Yanqiang , Cheng Xiaolong , Cui Yongping 
Published: January 2022

Due to the lack of effective diagnostic markers and therapeutic targets, esophageal squamous cell carcinoma (ESCC) shows a poor 5 years survival rate of less than 30%. To explore the potential therapeutic targets of ESCC, we integrated and reanalyzed the mutation data of WGS (whole genome sequencing) or WES (whole exome sequencing) from a total of 1,145 samples in 7 large ESCC cohorts, including 270 ESCC gene expression data. Two new mutation signatures and 20 driver genes were identified in our study. Among them, AP3S1, MUC16, and RPS15 were reported for the first time. We also discovered that the KMT2D was associated with the multiple clinical characteristics of ESCC, and KMT2D knockdown cells showed enhanced cell migration and cell invasion. Furthermore, a few neoantigens were shared between ESCC patients. For ESCC, compared to TMB, neoantigen might be treated as a better immunotherapy biomarker. Our research expands the understanding of ESCC mutations and helps the identification of ESCC biomarkers, especially for immunotherapy biomarkers.
Diagnostic, Prognostic, and Recurrence Monitoring Value of Plasma CYFRA21-1 and NSE Levels in Patients With Esophageal Squamous Cell Carcinoma
Authors: Ju Mengyang , Ge Xiaolin , Di Xiaoke , Zhang Yumeng , Liang Liang , Shi Yujing 
Published: January 2022

This study was aimed to evaluate the clinical values of single markers and combination in the diagnosis, short-term efficacy and recurrence risk assessment of esophageal squamous cell carcinoma (ESCC).MethodsTotally 50 patients with I-IVa stage ESCC, 50 healthy controls and 11 patients with recurrent esophageal cancer after comprehensive treatment were enrolled. Serum biomarkers were collected and evaluated. Serum concentrations of carcinoembryonic antigen (CEA), cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and neuron specific enolase (NSE) were measured by enzyme-linked immunosorbent assay before and after treatment.ResultsThe diagnostic efficacy ROC curve area of CEA, CYFRA21-1 and NSE in esophageal cancer was 0.70, 0.71 and 0.64(all P &lt;0.05), respectively, the sensitivity was 80%, 88.89% and 60% respectively, and the specificity was 53%, 58.5% and 58% respectively. The sensitivity and specificity of the combined detection were 68% and 78% respectively. The area under ROC curve was 0.75. CEA, CYFRA21-1 and NSE were significantly higher than the healthy control group and thus can be used as diagnostic markers of esophageal cancer (all P &lt;0.05). After standard treatment, the clinical CR and PR rate of patients with positive CYFRA21-1 or NSE before treatment was significantly lower than that of patients with negative CYFRA21-1 or NSE (X2 = 4.52,P =0.03). A significant negative correlation was found between N stage and clinical efficacy (HR 2.48, 95%CI 1.07-5.73). After comprehensive treatment, the serum CYFRA21-1 and NSE levels in recurrent patients also increased significantly(all P&lt;0.05), indicating these two markers play obvious roles in recurrence monitoring.ConclusionCYFRA21-1 and NSE may help to predict the response of ESCC to CRT, and play important roles in the diagnosis and recurrence monitoring of esophageal cancer. These markers have a diagnostic value of esophageal cancer when combined with CEA.
Peritoneal Cytokines as Early Biomarkers of Colorectal Anastomotic Leakage Following Surgery for Colorectal Cancer: A Meta-Analysis
Authors: Qi Xin-Yu , Liu Mao-Xing , Xu Kai , Gao Pin , Tan Fei , Yao Zhen-Dan , Zhang Nan , Yang Hong , Zhang Cheng-Hai , Xing Jia-Di , Cui Ming , Su Xiang-Qian 
Published: January 2022

BackgroundPostoperative colorectal anastomotic leakage (CAL) is a devastating complication following colorectal resection. However, the diagnosis of anastomotic leakage is often delayed because the current methods of identification are unable to achieve 100% clinical sensitivity and specificity. This meta-analysis aimed to evaluate the predictive value of peritoneal fluid cytokines in the detection of CAL following colorectal surgery.MethodsA comprehensive search was conducted on PubMed, Embase, Cochrane Library, and Web of Science before June 2021 to retrieve studies regarding peritoneal fluid cytokines as early markers of CAL. Pooled analyses of interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF) were performed. The means (MD) and standard deviations (SD) of the peritoneal fluid cytokines were extracted from the included studies. Review Manager Software 5.3 was used for data analysis.ResultsWe included eight studies with 580 patients, among which 85 (14.7%) and 522 (44.5%) were evaluated as the CAL and non-CAL groups, respectively. Compared to the non-CAL group, the CAL group had significantly higher peritoneal IL-6 levels on postoperative day (POD) 1–3 (P = 0.0006, 0.0002, and 0.002, respectively) and slightly higher TNF levels on POD 4 (P = 0.0002). Peritoneal levels of IL-1β and IL-10 were not significantly different between the two groups in this study.ConclusionPeritoneal IL-6 levels can be a diagnostic marker for CAL following colorectal surgery, whereas the value of TNF needs further exploration in the future.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/#myprospero], PROSPERO (CRD42021274973)