bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomic assessment of oesophageal adenocarcinoma: a critical review of 18F-FDG PET/CT, PET/MRI and CT
Authors: O’Shea Robert J. , Rookyard Chris , Withey Sam , Cook Gary J. R. , Tsoka Sophia , Goh Vicky 
Published: June 2022

Abstract
Objectives
Radiomic models present an avenue to improve oesophageal adenocarcinoma assessment through quantitative medical image analysis. However, model selection is complicated by the abundance of available predictors and the uncertainty of their relevance and reproducibility. This analysis reviews recent research to facilitate precedent-based model selection for prospective validation studies.

Methods
This analysis reviews research on 18F-FDG PET/CT, PET/MRI and CT radiomics in oesophageal adenocarcinoma between 2016 and 2021. Model design, testing and reporting are evaluated according to the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) score and Radiomics Quality Score (RQS). Key results and limitations are analysed to identify opportunities for future research in the area.

Results
Radiomic models of stage and therapeutic response demonstrated discriminative capacity, though clinical applications require greater sensitivity. Although radiomic models predict survival within institutions, generalisability is limited. Few radiomic features have been recommended independently by multiple studies.

Conclusions
Future research must prioritise prospective validation of previously proposed models to further clinical translation.
Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial
Authors: Valenzuela Michael , Duncan T. , Abey A. , Johnson A. , Boulamatsis C. , Dalton M. A. , Jacobson E. , Brunel L. , Child G. , Simpson D. , Buckland M. , Lowe A. , Siette J. , Westbrook F. , McGreevy P. 
Published: June 2022

Abstract
Background
Older companion dogs naturally develop a dementia-like syndrome with biological, clinical and therapeutic similarities to Alzheimer disease (AD). Given there has been no new safe, clinically effective and widely accessible treatment for AD for almost 20 years, an all-new cell therapeutic approach was trialled in canine veterinary patients, and further modelled in aged rats for more detailed neurobiological analysis.

Methods
A Phase 1/2A veterinary trial was conducted in N = 6 older companion dogs with definitive diagnosis of Canine Cognitive Dysfunction (CCD). Treatment comprised direct microinjection of 250,000 autologous skin-derived neuroprecursors (SKNs) into the bilateral hippocampus using MRI-guided stereotaxis. Safety was assessed clinically and efficacy using the validated Canine Cognitive Dysfunction Rating Scale (CCDR) at baseline and 3-month post treatment. Intention to treat analysis imputed a single patient that had a surgical adverse event requiring euthanasia. Three dog brains were donated following natural death and histology carried out to quantify Alzheimer pathology as well as immature neurons and synapses; these were compared to a brain bank (N = 12) of untreated aged dogs with and without CCD. Further, an age-related memory dysfunction rat model (N = 16) was used to more closely evaluate intrahippocampal engraftment of canine SKN cells, focusing on mnemonic and synaptic effects as well as donor cell survival, neurodifferentation and electrophysiologic circuit integration in a live hippocampal slice preparation.

Results
Four out-of-five dogs improved on the primary clinical CCDR endpoint, three fell below diagnostic threshold, and remarkably, two underwent full syndromal reversal lasting up to 2 years. At post mortem, synaptic density in the hippocampus specifically was nine standard deviations above non-treated dogs, and intensity of new neurons also several fold higher. There was no impact on AD pathology or long-term safety signals. Modelling in aged rats replicated the main canine trial findings: hippocampally-dependent place memory deficits were reversed and synaptic depletion rescued. In addition, this model confirmed donor cell survival and migration throughout the hippocampus, neuronal differentiation in situ, and physiologically-correct integration into pyramidal layer circuits.

Conclusions
With further development, SKN cell therapy may have potential for treating carefully chosen AD patients based on neurosynaptic restoration in the hippocampus.
Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma
Authors: Kitamura Koji , Suzuki Hidefumi , Abe Ryota , Inohara Hidenori , Kaneda Yasufumi , Takahashi Hidehisa , Nimura Keisuke 
Published: June 2022

AbstractRNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription machinery. Hence, some RNA splicing factors may play a role in transcription. Here, we show that the splicing factor SF3B2 binds to gene regulatory elements and mRNA to modulate transcription and RNA stability in head and neck squamous cell carcinoma cells. High SF3B2 expression leads to poor prognosis in patients with head and neck squamous cell carcinoma and to progression of tumor growth in mice. SF3B2 promotes tumor growth, owing to its involvement in activation of gene expression associated with mitochondrial electron transport and transcription regulatory region DNA binding. SF3B2 is enriched around the promoter element on chromatin and the transcription termination site on RNA. SF3B2 is involved in the regulation of RNA stability. According to the SF3B2-binding profile, SF3B2 regulates RNA polymerase II activity, in addition to regulating RNA splicing. Mechanistically, SF3B2 promotes the binding of structural maintenance of chromosomes 1A and CCCTC-binding factor (CTCF) to the SF3B2-binding genomic regions. SF3B2 also modulates CTCF transcriptional activity. Our findings indicate that SF3B2 has a dual function in both transcription and RNA stability, leading to head and neck squamous cell carcinoma progression.
Legal concerns in health-related artificial intelligence: a scoping review protocol
Authors: Da Silva Michael , Horsley Tanya , Singh Devin , Da Silva Emily , Ly Valentina , Thomas Bryan , Daniel Ryan C. , Chagal-Feferkorn Karni A. , Iantomasi Samantha , White Kelli , Kent Arianne , Flood Colleen M. 
Published: June 2022

Abstract
Background
Medical innovations offer tremendous hope. Yet, similar innovations in governance (law, policy, ethics) are likely necessary if society is to realize medical innovations’ fruits and avoid their pitfalls. As innovations in artificial intelligence (AI) advance at a rapid pace, scholars across multiple disciplines are articulating concerns in health-related AI that likely require legal responses to ensure the requisite balance. These scholarly perspectives may provide critical insights into the most pressing challenges that will help shape and advance future regulatory reforms. Yet, to the best of our knowledge, there is no comprehensive summary of the literature examining legal concerns in relation to health-related AI. We thus aim to summarize and map the literature examining legal concerns in health-related AI using a scoping review approach.

Methods
The scoping review framework developed by (J Soc Res Methodol 8:19-32, 2005) and extended by (Implement Sci 5:69, 2010) and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for scoping reviews (PRISMA-ScR) guided our protocol development. In close consultation with trained librarians, we will develop a highly sensitive search for MEDLINE® (OVID) and adapt it for multiple databases designed to comprehensively capture texts in law, medicine, nursing, pharmacy, other healthcare professions (e.g., dentistry, nutrition), public health, computer science, and engineering. English- and French-language records will be included if they examine health-related AI, describe or prioritize a legal concern in health-related AI or propose a solution thereto, and were published in 2012 or later. Eligibility assessment will be conducted independently and in duplicate at all review stages. Coded data will be analyzed along themes and stratified across discipline-specific literatures.

Discussion
This first-of-its-kind scoping review will summarize available literature examining, documenting, or prioritizing legal concerns in health-related AI to advance law and policy reform(s). The review may also reveal discipline-specific concerns, priorities, and proposed solutions to the concerns. It will thereby identify priority areas that should be the focus of future reforms and regulatory options available to stakeholders in reform processes.

Trial registration
This protocol was submitted to the Open Science Foundation registration database. See https://osf.io/zav7w.
Dietary supplementation with branched-chain amino acids enhances milk production by lactating sows and the growth of suckling piglets
Authors: Rezaei Reza , Gabriel Ana San , Wu Guoyao 
Published: June 2022

Abstract
Background
Under current dietary regimens, milk production by lactating sows is insufficient to sustain the maximal growth of their piglets. As precursors of glutamate and glutamine as well as substrates and activators of protein synthesis, branched-chain amino acids (BCAAs) have great potential for enhancing milk production by sows.

Methods
Thirty multiparous sows were assigned randomly into one of three groups: control (a corn- and soybean meal-based diet), the basal diet + 1.535% BCAAs; and the basal diet + 3.07% BCAAs. The ratio (g/g) among the supplemental L-isoleucine, L-leucine and L-valine was 1.00:2.56:1.23. Diets were made isonitrogenous by the addition of appropriate amounts of L-alanine. Lactating sows had free access to drinking water and their respective diets. The number of live-born piglets was standardized to 9 per sow at d 0 of lactation (the day of parturition). On d 3, 15 and 29 of lactation, body weights and milk consumption of piglets were measured, and blood samples were obtained from sows and piglets 2 h and 1 h after feeding and nursing, respectively.

Results
Feed intake did not differ among the three groups of sows. Concentrations of asparagine, glutamate, glutamine, citrulline, arginine, proline, BCAAs, and many other amino acids were greater (P < 0.05) in the plasma of BCAA-supplemented sows and their piglets than those in the control group. Compared with the control, dietary supplementation with 1.535% and 3.07% BCAAs increased (P < 0.05) concentrations of free and protein-bound BCAAs, glutamate plus glutamine, aspartate plus asparagine, and many other amino acids in milk; milk production by 14% and 21%, respectively; daily weight gains of piglets by 19% and 28%, respectively, while reducing preweaning mortality rates by 50% and 70%, respectively.

Conclusion
Dietary supplementation with up to 3.07% BCAAs enhanced milk production by lactating sows, and the growth and survival of their piglets.
An exploratory examination of executive functioning as an outcome, moderator, and predictor in outpatient treatment for adults with anorexia nervosa
Authors: Keegan Ella , Byrne Susan , Hay Phillipa , Touyz Stephen , Treasure Janet , Schmidt Ulrike , McIntosh Virginia V. W. , Wade Tracey D. 
Published: June 2022

Abstract
Objective
People with anorexia nervosa often exhibit inefficiencies in executive functioning (central coherence and set shifting) that may negatively impact on treatment outcomes. It is unclear from previous research whether these inefficiencies can change over treatment. We aimed to (1) investigate whether executive functioning can improve over treatment, (2) determine whether baseline executive functioning moderates treatment outcome, and (3) examine whether baseline executive functioning predicts early change (i.e., increase in body mass index over the first 13 weeks of treatment) or remission.

Method
We conducted linear mixed model and logistic regression analyses on data from the Strong Without Anorexia Nervosa trial (Byrne et al. in Psychol Med 47:2823–2833, 2017). This study was a randomised controlled trial of three outpatient treatments for people with anorexia nervosa: Enhanced Cognitive Behavioural Therapy, Maudsley Model Anorexia Nervosa Treatment for Adults, and Specialist Supportive Clinical Management.

Results
While set shifting clearly improved from baseline to end of treatment, the results for central coherence were less clear cut. People with low baseline central coherence had more rapid reductions in eating disorder psychopathology and clinical impairment than those with high baseline central coherence. Baseline executive functioning did not predict early change or remission.

Discussion
The detail-focused thinking style commonly observed among people with anorexia nervosa may aid treatment outcomes. Future research that is more adequately powered should replicate this study and examine whether the same pattern of results is observed among people with non-underweight eating disorders.
Blue pigments in Cave 256, Mogao Grottoes: a systematic analysis of murals and statues in Five dynasties, Song Dynasty and Qing Dynasty
Authors: Shui Biwen , Yu Zongren , Cui Qiang , Wang Zhuo , Yin Zhiyuan , Sun Manli , Su Boming 
Published: June 2022

Abstract
Murals of Cave 256, Mogao Grottoes consist of several layers, with the outermost layer overlays all others. The bottom layer was painted in the five dynasties. The outermost layer was mural of the Song Dynasty. Statues were repainted in the Qing Dynasty. We found that different blue pigments are used in multilayer murals which reflects the social development at that time to a certain extent. In order to know the type of blue pigments, technology such as X-ray diffraction, microscopic FTIR spectroscopy and polarizing microscope were used for analysis of trace samples based on non-destructive research through the portable X-ray fluorescence. As a result, we know that Lazurite was used as blue pigment in murals of the Five Dynasties and Azurite was used in the Song Dynasty. Smalt used in statues of the Qing Dynasty was first discovered in Mogao Grottoes. It can be inferred from the discovery of smalt that statues of the Qing Dynasty in Cave 256 were repainted in the first half of the nineteenth century.
A better entity detection of question for knowledge graph question answering through extracting position-based patterns
Authors: Yani Mohammad , Krisnadhi Adila Alfa , Budi Indra 
Published: June 2022

AbstractEntity detection task on knowledge graph question answering systems has been studied well on simple questions. However, the task is still challenging on complex questions. It is due to a complex question is composed of more than one fact or triple. This paper proposes a method to detect entities and their position on triples mentioned in a question. Unlike existing approaches that only focus on detecting the entity name, our method can determine in which triple an entity is located. Furthermore, our approach can also define if an entity is a head or a tail of a triple mentioned in a question. We tested our approach to SimpleQuestions, LC-QuAD 2.0, and QALD series benchmarks. The experiment result demonstrates that our model outperforms the previous works on SimpleQuestions and QALD series datasets. 99.15% accuracy and 96.15% accuracy on average, respectively. Our model can also improve entity detection performance on LC-QuAD 2.0 with a merged dataset, namely, 97.4% accuracy. This paper also presents Wikidata QALD series version that is helpful for researchers to assess the knowledge graph question answering system they develop.
Extracorporeal cardiopulmonary resuscitation with temperature management could improve the neurological outcomes of out-of-hospital cardiac arrest: a retrospective analysis of a nationwide multicenter observational study in Japan
Authors: Sakurai Toshihiro , Kaneko Tadashi , Yamada Shu , Takahashi Takeshi 
Published: June 2022

Abstract
Background
Target temperature management (TTM) is an effective component of treating out-of-hospital cardiac arrest (OHCA) after return of spontaneous circulation in conventional cardiopulmonary resuscitation. However, therapeutic hypothermia (32–34 °C TTM) is not recommended based on the results of recent studies. Extracorporeal cardiopulmonary resuscitation (ECPR) with veno-arterial extracorporeal membrane oxygenation is another promising therapy for OHCA, but few studies have examined the effectiveness of ECPR with TTM. Therefore, we hypothesized that ECPR with TTM could have the effectiveness to improve the neurological outcomes for adults following witnessed OHCA, in comparison to ECPR without TTM.

Methods
We performed retrospective subanalyses of the Japanese Association for Acute Medicine OHCA registry. We focused on adults who underwent ECPR for witnessed OHCA. We performed univariate (the Mann–Whitney U test and Fisher’s exact test), multivariable (logistic regression analyses), and propensity score analyses (the inverse probability of the treatment-weighting method) with to compare the neurological outcomes between patients with or without TTM, among all eligible patients, patients with a cardiogenic cause, and patients divided into subgroups according to the interval from collapse to pump start (ICPS) (> 30, > 45, or > 60 min).

Results
We analyzed data for 977 patients. Among 471 patients treated with TTM, the target temperature was therapeutic hypothermia in 70%, and the median interval from collapse to target temperature was 249 min. Propensity score analysis showed a positive association between TTM and favorable neurological outcomes in all patients (odds ratio 1.546 [95% confidence interval 1.046–2.286], P = 0.029), and in patients with ICPS of > 30 or > 45 min, but not in those with ICPS of > 60 min. The propensity score analysis also showed a positive association between TTM and favorable neurological outcomes in patients with a cardiogenic cause (odds ratio 1.655 [95% confidence interval 1.096–2.500], P = 0.017), including in all ICPS subgroups (> 30, > 45, and > 60 min).

Conclusion
Within patients who underwent ECPR following OHCA, ECPR with TTM could show the potential of improvement in the neurological outcomes, compared to ECPR without TTM.
Climatic zonation of Egypt based on high-resolution dataset using image clustering technique
Authors: Hamed Mohammed Magdy , Nashwan Mohamed Salem , Shahid Shamsuddin 
Published: June 2022

AbstractEgypt, a predominantly arid and hyper-arid country, is one of the environmentally most fragile regions of the world. The country became a hot spot for climatic extremes and aridity change in the global warming context. The unavailability of a detailed and reliable climate zonation map is a major hindrance to climatic studies in Egypt. This study attempted to generate a high-resolution climate zone map of Egypt based on a novel image analysis technique. For this purpose, a colored image representing Egypt's composite climatology was developed using three high-resolution (1-km) climate variables: rainfall, maximum temperature and minimum temperature during 1979–2013. A spherical evolution algorithm was used to classify the image into different climate zones. Subsequently, the climate zones representing similar climate distribution were merged to generate the climate map of Egypt. The study revealed that Egypt’s distinguishable climate zones could be recognized when the land area was classified into nine zones using the image analysis technique. The statistical analysis of climate variables of each zone revealed similar climatology only in two pairs of zones. The merging of similar climate zones yielded seven climate zones having distinct climate characteristics. The validation of climate zonation using various statistical tests revealed the robustness of the proposed method in classifying climate. The climate zone map generated in the study can be used as a reference for climate change analysis in Egypt.
Human-mimetic binaural ear design and sound source direction estimation for task realization of musculoskeletal humanoids
Authors: Omura Yusuke , Kawaharazuka Kento , Nagamatsu Yuya , Koga Yuya , Nishiura Manabu , Toshimitsu Yasunori , Asano Yuki , Okada Kei , Kawasaki Koji , Inaba Masayuki 
Published: June 2022

AbstractHuman-like environment recognition by musculoskeletal humanoids is important for task realization in real complex environments and for use as dummies for test subjects. Humans integrate various sensory information to perceive their surroundings, and hearing is particularly useful for recognizing objects out of view or out of touch. In this research, we aim to realize human-like auditory environmental recognition and task realization for musculoskeletal humanoids by equipping them with a human-like auditory processing system. Humans realize sound-based environmental recognition by estimating directions of the sound sources and detecting environmental sounds based on changes in the time and frequency domain of incoming sounds and the integration of auditory information in the central nervous system. We propose a human mimetic auditory information processing system, which consists of three components: the human mimetic binaural ear unit, which mimics human ear structure and characteristics, the sound source direction estimation system, and the environmental sound detection system, which mimics processing in the central nervous system. We apply it to Musashi, a human mimetic musculoskeletal humanoid, and have it perform tasks that require sound information outside of view in real noisy environments to confirm the usefulness of the proposed methods.
Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up
Authors: Cui Guang-Ying , Rao Ben-Chen , Zeng Zhao-Hai , Wang Xue-Mei , Ren Tong , Wang Hai-Yu , Luo Hong , Ren Hong-Yan , Liu Chao , Ding Su-Ying , Tan Jun-Jie , Liu Zhen-Guo , Zou Ya-Wen , Ren Zhi-Gang , Yu Zu-Jiang 
Published: June 2022

Abstract
Background
Due to the outbreak and rapid spread of coronavirus disease 2019 (COVID-19), more than 160 million patients have become convalescents worldwide to date. Significant alterations have occurred in the gut and oral microbiome and metabonomics of patients with COVID-19. However, it is unknown whether their characteristics return to normal after the 1-year recovery.

Methods
We recruited 35 confirmed patients to provide specimens at discharge and one year later, as well as 160 healthy controls. A total of 497 samples were prospectively collected, including 219 tongue-coating, 129 stool and 149 plasma samples. Tongue-coating and stool samples were subjected to 16S rRNA sequencing, and plasma samples were subjected to untargeted metabolomics testing.

Results
The oral and gut microbiome and metabolomics characteristics of the 1-year convalescents were restored to a large extent but did not completely return to normal. In the recovery process, the microbial diversity gradually increased. Butyric acid-producing microbes and Bifidobacterium gradually increased, whereas lipopolysaccharide-producing microbes gradually decreased. In addition, sphingosine-1-phosphate, which is closely related to the inflammatory factor storm of COVID-19, increased significantly during the recovery process. Moreover, the predictive models established based on the microbiome and metabolites of patients at the time of discharge reached high efficacy in predicting their neutralizing antibody levels one year later.

Conclusions
This study is the first to characterize the oral and gut microbiome and metabonomics in 1-year convalescents of COVID-19. The key microbiome and metabolites in the process of recovery were identified, and provided new treatment ideas for accelerating recovery. And the predictive models based on the microbiome and metabolomics afford new insights for predicting the recovery situation which benefited affected individuals and healthcare.