bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines
Authors: Cavalcanti Jacqueline V. J. , Selting Kimberly A. , Ngo Mai T. , Tran Hoang Christine K. , Schaeffer David J. , Fan Timothy M. , Harley Brendan A. C. , Phillips Heidi 
Published: May 2022

Abstract

OBJECTIVE
To evaluate feline injection site-associated sarcoma (FISAS) and oral squamous cell carcinoma (FOSCC) cells in 3-D hydrogel-based cell cultures to determine chemosensitivity to carboplatin at concentrations comparable to those eluted from carboplatin-impregnated calcium sulfate hemihydrate (C-ICSH) beads.

SAMPLE
2 immortalized cell lines, each from a histologically confirmed primary FISAS and FOSCC.

PROCEDURES
Hydrogels (10% wt/vol) were formed via UV exposure from methacrylamide-functionalized gelatin dissolved in PBSS. For each cell line, approximately 100,000 cells were encapsulated per hydrogel. Three cell-seeded 3-D hydrogels were evaluated for each carboplatin concentration (0, 150, 300, 450, and 600 µM) across 3 experiments. Drug efficacy was assessed by luminescence assay 72 hours after treatment. Growth of tumor cells treated with 300 µM or 600 µM carboplatin was evaluated using live-cell morphology imaging and confocal microscopy at 3, 7, and 14 days after treatment.

RESULTS
Mean half-maximal inhibitory concentration (IC50) values for FISAS and FOSCC cells ranged from 123 to 171 µM and 155 to 190 µM, respectively, based on luminescence assay. Viability at 3, 7, and 14 days for both cell lines at 300 µM carboplatin was 50%, 25%, and 5% and at 600 µM carboplatin was 25%, 10%, and < 5%.

CLINICAL RELEVANCE
3-D hydrogel cell culture systems supported growth of feline tumor cells for determination of in vitro chemosensitivity. IC50s of each cell line were within the range of carboplatin concentrations eluted from C-ICSH beads. Cells from FISAS and FOSCC cell lines treated with carboplatin showed dose-dependent and time-dependent decreases in viability.
Veterinarians’ use of the Talking Physical Exam as a communication tool
Authors: da Costa Judith C. , Coe Jason B. , Blois Shauna L. , Stone Elizabeth A. 
Published: May 2022

Abstract

OBJECTIVE
To describe veterinarians’ communication of the companion animal physical exam (CAPE) to veterinary clients and to identify factors associated with the number of physical exam components communicated by veterinarians to clients.

SAMPLE
376 video-recorded veterinarian-client-patient interactions, involving 60 veterinarians.

PROCEDURES
18 CAPE components were studied in relation to veterinarians’ use of 7 communication-related parameters. A mixed linear regression model was used to assess veterinarian, patient, and appointment factors associated with the number of components conveyed by a veterinarian.

RESULTS
Veterinarians conveyed 1,566 of 2,794 (56.1%) of the components that they examined to clients, as having been examined. Of those components that were examined and conveyed by veterinarians, the impact of the finding was communicated for 496 of 1,566 (31.7%) of the components. Visual aids and take-home literature were each used in relation to an examined component during 15 of the 376 interactions (4%). A significant association was found between number of CAPE components conveyed and gender of the veterinarian (females conveyed 1.31 more), as well as the type of appointment (2.57 more were conveyed in wellness appointments and 1.37 more in problem appointments, compared to rechecks).

CLINICAL RELEVANCE
Findings identify an opportunity for veterinarians to further emphasize components of the CAPE, which may in turn increase clients’ perceived value of the CAPE due to understanding the benefits for their pet. This may be accomplished with the Talking Physical Exam, in which veterinarians discuss CAPE components findings with clients in real time, and the relevance of the findings to the patient’s health.
Bronchoscopic Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage-induced Acute Respiratory Failure in MPO-ANCA Vasculitis: A Case Report
Authors: Smesseim Illaa , Schaepman-Ruys Titia , Duitman Jan Willem , Vegting Yosta , Raasveld Jorinde , Hilhorst Marc , Vlaar Alexander , van Es Josien , Bonta Peter 
Published: May 2022

Abstract

Introduction
Diffuse alveolar haemorrhage (DAH) is a potentially life-threatening disease, characterized by diffuse accumulation of red blood cells within the alveoli. It can be caused by a variety of disorders. In case DAH results in severe respiratory failure, veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be required. Since VV-ECMO coincides with the need for anticoagulation therapy, this results in a major clinical challenge in DAH patients with hemoptysis.

Case presentation
We report a patient case with severe DAH-induced acute respiratory failure and hemoptysis in need for VV-ECMO complicated by life-threatening membrane oxygenator thrombosis. The DAH-induced hemoptysis was successfully treated with local bronchoscopic recombinant factor VIIa (rFVIIa), allowing systemic anticoagulation to prevent further membrane oxygenator thrombosis. Neither systemic clinical side effects nor differences in the serum coagulation markers occurred after applying recombinant factor VIIa (rFVIIa) treatment endobronchially.

Conclusion
This is, to our knowledge, the first case that reports the use of rFVIIa in a patient with DAH due to vasculitis and in need for VV-ECMO complicated by membrane oxygenator thrombosis.
Severe Coronary Artery Vasospasm after Mitral Valve Replacement in a Diabetic Patient with Previous Stent Implantation: A Case Report
Authors: Stoica Alexandra Iulia , Harpa Marius , Banceu Cosmin Marian , Kovacs Judith , Suciu Horatiu 
Published: May 2022

Abstract
Postoperative coronary vasospasm is a well-known cause of angina that may lead to myocardial infarction if not treated promptly. We report a case of a 70-year-old female with severe mitral regurgitation submitted to mitral valve replacement, and a history of diabetes mellitus type II, stroke, idiopathic thrombocytopenic purpura on steroid therapy, and previous percutaneous coronary intervention (PCI) for severe obstruction of the circumflex coronary artery, 4 months prior to surgery. Immediately after intensive care unit admission, the patient developed pulseless electrical activity which required extracorporeal membrane oxygenation for hemodynamic support. The coronary angiography showed diffuse occlusive coronary artery vasospasm, ameliorated after intra-coronary administration of nitroglycerin. The following postoperative evolution was marked by cardiogenic shock and multiple organ dysfunction syndrome. Subsequent echocardiographic findings showed an increase in left ventricular function with an EF of 40%, and extracorporeal membrane oxygenation (ECMO) support was weaned after seven days. However, after a few hours, the patient progressively deteriorated, with cardiac arrest and no response to resuscitation maneuvers. Hemodynamic instability following the surgical procedure in a patient with previous PCI associated with an autoimmune disease and diabetes mellitus should raise the suspicion of a coronary artery vasospasm.
Ecological and morphological differentiation among COI haplotype groups in the plant parasitic nematode species Mesocriconema xenoplax
Authors: Matczyszyn Julianne N. , Harris Timothy , Powers Kirsten , Everhart Sydney E. , Powers Thomas O. 
Published: May 2022

Abstract
DNA barcoding with the mitochondrial COI gene reveals distinct haplotype subgroups within the monophyletic and parthenogenetic nematode species, Mesocriconema xenoplax. Biological attributes of these haplotype groups (HG) have not been explored. An analysis of M. xenoplax from 40 North American sites representing both native plant communities and agroecosystems was conducted to identify possible subgroup associations with ecological, physiological, or geographic factors. A dataset of 132 M. xenoplax specimens was used to generate sequences of a 712 bp region of the cytochrome oxidase subunit I gene. Maximum-likelihood and Bayesian phylogenies recognized seven COI HG (≥99/0.99 posterior probability/bootstrap value). Species delimitation metrics largely supported the genetic integrity of the HG. Discriminant function analysis of HG morphological traits identified stylet length, total body length, and stylet knob width as the strongest distinguishing features among the seven groups, with stylet length as the strongest single distinguishing morphological feature. Multivariate analysis identified land cover, ecoregion, and maximum temperature as predictors of 53.6% of the total variation (P = 0.001). Within land cover, HG categorized under “herbaceous,” “woody wetlands,” and “deciduous forest” were distinct in DAPC and RDA analyses and were significantly different (analysis of molecular variance P = 0.001). These results provide empirical evidence for molecular, morphological, and ecological differentiation associated with HG within the monophyletic clade that represents the species Mesocriconema xenoplax.
Dynamics of hydrological droughts propagation in mountainous catchments
Authors: Kozek Malwina , Tomaszewski Edmund 
Published: May 2022

Abstract
In the study, hydrological drought was identified assuming that the occurrence of river low-flow is a symptom of drought, and is also a good estimator of its progress. The research was conducted in the upper Dunajec river catchment, for which a series of daily discharges from 20 gauging stations during the period 1989–2018 were available. The low-flow periods were identified on the basis of the Threshold Level Method, which corresponds to the seventieth percentile of the flow duration curve. On the basis of a developed algorithm, 41 drought events were identified. Analysis included spatial parameters referring to range, severity, concentration, continuation, and the development pace of hydrological drought. Finally, on the basis of cluster analysis, five dynamic types of hydrological drought were identified.
Municipal investment expenditures by pork-barrel mayors: evidence from a transition economy
Authors: Leśniewska-Napierała Katarzyna , Napierała Tomasz 
Published: May 2022

Abstract
The focus of this study is electoral accounting practices employed by mayors in municipalities in a selected, exemplary region in a post-socialist country – the Lodz region in Central Poland. The goal is to identify characteristics of pork-barrel mayors responsible for municipal investment expenditures: their terms of office, partisan affiliation, and gender. The generalised method of moments was applied to estimate the impact that the electoral accounting practices of mayors had on municipal investment expenditures. All 177 municipalities in the Lodz region were investigated, from 2003 until 2019. Contrary to expectations, it was found that electoral accounting was practised by next-term and independent mayors rather than first-term or party-affiliated ones.
SIX NEW SPECIES OF WURFBAINIA (ZINGIBERACEAE) FROM THAILAND
Authors: Kaewsri W. , Sangvirotjanapat S. 
Published: May 2022

Six new species are described from Thailand: Wurfbainia ellipticarpa, W. geostachyoides, W. globosa, W. longiflora, W. parviflora and W. yingyongii. A line drawing and photographs, information on phenology, distribution, ecology and etymology, and a proposed IUCN conservation category are provided for each species. A key to the species of Wurfbainia in Thailand is also provided.
O uso de agrotóxicos no Brasil a partir de uma visão histórica acerca das bases legislativas
Authors: Sousa Damiao sampaio de , Mendes Francisco Rogênio da Silva , Vasconcelos Sandro Olímpio Silva , Santos Hélcio Silva dos , Marinho Gabrielle Silva , Marinho Márcia Machado , Marinho Emmanuel Silva 
Published: May 2022

Introdução: O Brasil tornou-se um dos maiores consumidores de agrotóxicos do mundo, devido ao sistema agrícola convencional, arcabouço tecnológico e influência política, fatores esses que contribuíram para uma industrialização rápida, imprudente e precoce. Entretanto, a preocupação com a preservação ambiental e saúde pública foram negligenciados, pois os interesses das empresas multinacionais e políticos prevaleceram acerca das questões sanitárias. Objetivo: O estudo é uma reflexão acerca da temática dos agrotóxicos no cenário brasileiro, com ênfase na faixa histórica da legislação brasileira, na perspectiva da proteção ambiental e saúde coletiva. Metodologia: Foi baseada em uma análise legislativa dos agrotóxicos no Brasil fundamentada em uma faixa histórica de antes e depois da Constituição Federal de 1988 visando investigar os avanços e retrocessos políticos no aspecto ambiental. Resultados: A partir do referencial histórico percebe-se que anterior a Lei dos Agrotóxicos a liberação de agrotóxicos no Brasil foi facilitada pela criação de diversos instrumentos legislativos com influências sociais, econômicas e políticas. As demais legislações instituídas após 1988, nota-se as perceptíveis tentativas de retrocessos diante dos aspectos de monitoramento e liberação de agrotóxicos. Conclusão: Aponta-se que a legislação dos agrotóxicos apesar de seus avanços está perante um retrocesso histórico após diversas lutas e vitórias, apresentando de forma contundente, que essa nova construção histórica ambiental envolve em sua maior componente influências políticas.
دبلوماسية إقليم كوردستان في حل المشاكل المائية مع دول الجوار(2014-2020)
Authors: حسن ميران حسين , رحمان هژار عثمان , عثمان بێستون عبدالمجید 
Published: May 2022

ان المشاكل المائية تعد من المشاكل الرئيسية والتي تعاني منها دول العالم في الوقت الحاضر بسبب التغييرات المناخية وانخفاض معدلات الامطار على مستوى العالم ،مما دفع جميع الدول بترشيد استهلاك المياه وانشاء المشاريع المائية. وان العراق واقليم كوردستان تعانيان من مشكلة قيام كل من ايران وتركيا بانشاء المشاريع المياه على المصادر المائية والتي تدخل العراق ،مما يتطلب جهود دبلوماسية كبيرة لحل هذه المشكلة، وان اقليم كوردستان باعتباره كيان قانوني ودستوري ان يمارس دورا في حل المشاكل مع الدول المجاورة في كافة المجالات لما يمتلكه مع ادوات ضغط على الدول ووجود علاقات متميزة بين الاقليم وهذه الدول.
The Impact of Information and Communication Technology on Marketing Performance:
Authors: Hamad Zana O. , Rashid Pshtiwan T. , Ahmed Rzgar H. 
Published: May 2022

Technology advancement has supported the market performance around the world even in the developing world. Moreover, firms in the market seek finding best means to reach to customers and also develop their business gradually and efficiently. This study is a quantitative study, the survey aims to identify and clarify how information and communication technology affect marketing performance at Majid Mall in Sulaimania. The survey has close-ended question, seeking the answers of the questions aimed at examining all of the hypotheses tested in this study. The research community in this study consisted of employees at Majid mall supermarket in Sulemani. This survey is descriptive and correlational. This survey was a random sampling for employees in Majid mall, in which 120 participants from the administrative staff of the mall have taken part voluntarily. For analyzing the collected empirical data the researchers used the software package for statistical analysis SPSS V.21 and for testing all hypotheses through the regression method. The results showed that the statistical process of hypothesis testing has revealed the remarkable role of ICT based on using (network, database, and software) is the greatest significance where (Beta= 0.366, Sig= 0.004) it positively and straightway retreats on marketing performance. The researchers recommend improving ICT facilities in Majid mall shopping for the sake of improving their market performance in the long-run. Moreover, it supports employee's development in terms of quantity, quality, and promotes the ICT culture through the formulation and implementation of more frequent technology-specific training programs for their staff.
Pedagogical development of the relationship between the creativity of V. V. Mayakovsky, A.M. Gorky and Mordovian literature
Authors: Сергушина Е. С. , Кабанов О. В. , Парфенов Е. А. , Редников Д. В. 
Published: May 2022

В данной статье рассмотрена взаимосвязь творчества В. В. Маяковского и А. М. Горького и мордовской литературы. Авторы статьи приходят к выводу, что В. В. Маяковский и А. М. Горький оказали огромное влияние на развитие не только русской литературы ХХ века, но и мордовской. Авторы отмечают, что влияние В. В. Маяковского на мордовскую литературу состоит не в подражании, а имеет творческий характер. Многое сближает мордовских писателей с русским поэтом, привлекавшим к себе гуманной заостренностью своей поэзии, стремлением к поискам новых форм. В Горьком их привлекает любовь к жизни, к человеку и его гуманизм.
This article examines the relationship between the creativity of V. V. Mayakovsky and A.M. Gorky and Mordovian literature. The authors of the article come to the conclusion that V. V. Mayakovsky and A.M. Gorky had a huge impact on the development of not only Russian literature of the twentieth century, but also Mordovian literature. The authors note that the influence of V. V. Mayakovsky on Mordovian literature does not consist in imitation, but has a creative character. There are many things that bring Mordovian writers closer to the Russian poet, who attracted to himself the humane sharpness of his poetry, the desire to search for new forms. In Gorky, they are attracted by the love of life, to man and his humanism.
Methodological potential of the dystopia genre in the development of students' reading competence
Authors: Ушакова Е. В. 
Published: May 2022

В статье рассматриваются характерные черты антиутопий и анализируются причины их популярности среди студентов. Обозначен круг проблем, затронутых в этих произведениях, и намечены возможности обращения к данному жанру в обучении, его значительный потенциал в формировании читательской компетентности студентов. Отмечается, что в современной ситуации, когда происходит падение интереса к чтению, именно данный жанр может помочь увлечь обучающихся в мир литературы. Немаловажным аспектом является и использование на занятиях элементов сопоставления произведений современного кинематографа и художественной литературы, выявление схожих сюжетных особенностей и проблематики, что способствует развитию критического мышления. Разработаны вопросы и задания, рекомендации по работе на занятиях по истории литературы в колледже и вузе, определены условия и этапы проведения семинаров и дискуссий. Представлены пути решения проблемы повышения интереса студентов к изучению творчества русских и зарубежных писателей. Предложенные для анализа романы-антиутопии затрагивают проблемы свободы и независимости личности, обретения ценностных ориентиров, роли прогресса и господства современных научных технологий в развитии человечества как наиболее близких для молодого поколения в поисках самоопределения.
The article discusses the characteristic features of dystopias and analyzes the reasons for their popularity among students. The range of problems raised in these works is outlined, and the possibilities of turning to this genre in education, its significant potential in shaping the reading competence of students are outlined. It is noted that in the current situation, when there is a drop in interest in reading, it is this genre that can help to captivate students into the world of literature. An important aspect is the use in the classroom of elements of comparing modern cinema and fiction works, the identification of similar plot features and issues, which contributes to the development of critical thinking. Questions and assignments, recommendations for work in the history of literature classes at colleges and universities have been developed, conditions and stages for holding seminars and discussions have been determined. The ways of solving the problem of increasing the students’ interest in the study of the work of Russian and foreign writers are presented. The dystopian novels proposed for analysis touch upon the problems of freedom and independence of the individual, obtaining value orientations, the role of progress and the dominance of modern scientific technologies in the development of mankind as the closest for the younger generation in search of self-determination.
Les noces gitanes dévoilées : étude et traduction des alboreás de Rafael Romero
Authors: GARCÍA PLATA-GÓMEZ Mercedes 
Published: May 2022

Le présent article propose l’étude et la traduction des alboreás enregistrées par Rafael Romero pour la Antología del cante flamenco dirigée par Perico el del Lunar (Hispavox, [1954] 1958). La traduction du chant, l’inventaire des variantes des coplas qui le composent et leur classement systématique ont permis de mettre au jour différents motifs thématiques que la copla dite des « trois roses » (la plus enregistrée et diffusée) ne laissait pas percevoir de prime abord. Le commentaire de ce chant d’anthologie — c’était la première fois que des alboreás, habituellement réservées aux noces gitanes figuraient sur un enregistrement sonore — apporte ainsi les éléments de contexte nécessaires à sa compréhension, en particulier sur le déroulement du rituel nuptial.
Qui cause ? Qui dose ? Qui ose ?À l’infini poème apporter une fin
Authors: Souchier Emmanuël , Pomian Joanna 
Published: May 2022

Situant son propos dans l’espace théorique de « l’énonciation éditoriale » et du « numérique comme écriture », l’auteur interroge les paradigmes de la pensée linguistique et statistique qui président à la constitution des algorithmes de recherche dédiés à l’analyse des données textuelles ; il invite à questionner les épistémies qui conduisent à leur conception avant d’envisager les résultats qu’ils produisent ; il s’interroge sur les bienfaits d’outils d’aide à l’édition critique des textes dans le cadre d’un programme de recherche en Intelligence artificielle sur la critique littéraire (Cattleya) et revient sur les bienfaits de l’activité médiévale de lettrure (lecture-écriture) pour l’édition scientifique des textes littéraires. Avec Joanna Pomian, il s’enquiert des acquis conceptuels, théoriques et méthodologiques de Cattleya. En toile de fond, quarante années de recherche et une interrogation sur les conditions politiques et intellectuelles de la recherche actuelle : et si on faisait confiance aux jeunes chercheurs en songeant à des « humanités » non plus « numériques » mais bien « intellectuelles » ?
Du StopCovid au « Pass sanitaire » : l’évolution du QR code au cours de la crise sanitaire de COVID-19
Authors: ZHANG Yuwen 
Published: May 2022

Au fil du développement de la crise sanitaire liée à la COVID-19, de plus en plus de pays ont adopté le dispositif de type « pass sanitaire » pour tenter d’endiguer la propagation du virus. Cet article prend le « pass sanitaire » français comme objet de recherche, en le comparant avec le QR code de santé chinois. Il affirme que, premièrement, la conception et l’usage du « pass sanitaire » favorise l’indépendance technologique et la gouvernance numérique en France. Deuxièmement, bien que l’usage technique du QR code soit différent, de StopCovid au « pass sanitaire », il construit tout de même une surveillance du grand public à travers un dispositif numérique en France comme en Chine. Enfin, cette QR code-isation sociale renforce une potentielle classification des individus reposant sur la collecte des données personnelles.