bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningitis due to inflammatory reaction to Echinococcus antigen after the resection of cerebral alveolar hydatid cyst
Authors: Yoshida Taishin , Yamamoto Shota , Yuzawa Sayaka , Takano Takuma , Sanada Takahiro , Saito Masato , Tanino Mishie , Kinoshita Manabu 
Published: February 2025

Abstract
Meningitis after resection of a cerebral alveolar hydatid cyst (CAHC) is rare. Although several etiologies are proposed for meningitis, including recurrence or inflammatory reaction to dead echinococcal antigens, the effectiveness of treatment strategies specifically targeting the inflammatory reaction has not been reported. A 72-year-old patient presented with a brain cyst suggestive of CAHC. The cyst ruptured during resection, which was immediately replaced with 95% ethanol to obliterate the viable larvae, followed by cyst removal. One-month post-surgery, the patient showed signs of meningitis suggestive of a recurrence of cerebral hydatidosis. However, the negative sign of the recurrence on the brain and whole spine MRI suggested an inflammatory reaction to the obliterated Echinococcus antigen. An increased dose of prednisone resulted in the patient’s complete recovery without recurrence for 1.8 years. Adding steroids to the anthelmintic maintenance treatment could be reasonable if the inflammatory reaction is more likely to be the cause.
Small bowel obstruction unmasking an internal hernia through a broad ligament defect: a case report
Authors: Slimi Youness , Frikal Mohammed , Mahmoudi Mohammed , Haddar Karim , Boukabous Houssam , Guellil Abdelali , Jabi Rachid , Skiker Imane , Bouziane Mohammed 
Published: February 2025

Abstract
Internal hernias are rare occurrences in which abdominal organs protrude through a mesenteric defect. Among these, herniation through the broad ligament is an especially uncommon type, comprising only 4% of all internal hernias. This condition can present with a wide spectrum of symptoms, ranging from abdominal pain to acute small bowel obstruction. Diagnosis is often difficult due to nonspecific clinical and radiological signs, making the condition a challenge to detect preoperatively. We present the case of a 30-year-old woman who developed an acute small bowel obstruction, identified through a CT scan. Surgical exploration revealed an incarcerated internal hernia passing through a defect in the broad ligament. After releasing the incarcerated bowel and closing the hernial orifice, the patient made a full recovery. This case provides additional insight into broad ligament hernias and the surgical approach to this rare condition.
Potential unrecognized redox-active atypical thioredoxins in eukaryote photosynthetic organisms
Authors: de Bont Linda , Donnay Natacha , Favier Frédérique , Couturier Jérémy , Didierjean Claude , Rouhier Nicolas 
Published: February 2025

Abstract
Photosynthetic organisms have a high diversity of proteins belonging to the thioredoxin (TRX) superfamily. It comprises more than 150 proteins distributed in different families and classes, including in particular thioredoxins, glutaredoxins, protein disulfide isomerases, thiol peroxidases or glutathione transferases, which share the thioredoxin structural fold. Many of them have one or two redox-active cysteines and a characteristic cis-proline at specific positions, but also additional domains or secondary structures at either end or inserted into the protein core. With the aim of further describing the TRX family in plants, we identified a set of 17 atypical TRX-like proteins from Arabidopsis thaliana, which have not been considered before despite having both a TRX fold and the CxxC/S signature typical of redox-active TRX. The in silico sequence and structure analyses revealed that they are distributed in eight distinct classes with unique active site signatures and structures, some with DsbA and peroxiredoxin-like folds. The distinct subcellular localizations (plastids, mitochondria, extracellular space) and gene expression profiles suggest that these proteins are involved in diverse cellular processes, further expanding the set of proteins involved in redox regulation and/or stress adaptation. These results further reveal the diversity in structure and function of atypical TRXs in plants.
Postural Sway Measurement Using a Body-Worn Movement Sensor in Clinical Stroke Rehabilitation: Exploring Sensitivity to Change and Responsiveness
Authors: Geerars Marieke , Wouda Natasja C , Felius Richard A W , Visser-Meily Johanna M A , Pisters Martijn F , Punt Michiel 
Published: February 2025

Abstract

Importance
During rehabilitation, stroke survivor’s balance is commonly monitored using the Berg Balance Scale (BBS) and Mini-BESTest. These tests evaluate the ability to maintain balance in an upright position while performing tasks. Currently, clinical practice lacks an adequate assessment of balance impairments like the increased postural sway post-stroke. Integrating postural sway measurement with a body-worn Inertial Measurement Unit (IMU) could offer clinicians an objective, and rapid measurement method.

Objective
Sensitivity to change and responsiveness of postural sway measurement during stroke rehabilitation were explored.

Design
A longitudinal study was conducted.

Setting
Data were collected in five rehabilitation centers.

Participants
Ninety-four stroke survivors were included in the study.

Intervention
Sensitivity to change was evaluated by comparing the percentages of participants who exceeded the Minimal Detectable Change (MDC) for both the conventional and IMU tests. Responsiveness was assessed through hypotheses testing, utilizing both a criterion approach (external criterion: a 5-point retrospective Global Rating of Change score) and a construct approach.

Results
At discharge, only 3.2% to 23.9% of the participants showed genuine improvement (ie, had a lower postural sway) on the IMU test, compared to 33% to 60% on the conventional tests. In total, 67.4% of the hypotheses were rejected.

Conclusions
The sensitivity to change and responsiveness of postural sway measurement in stroke survivors are limited. Restoring balance to achieve functional independence is not necessarily dependent on, or associated with, the level of postural sway. At present, integrating postural sway measurement into clinical stroke rehabilitation seems to provide no added value for monitoring balance.

Relevance
A novel approach to balance assessment in clinical stroke rehabilitation was investigated. It was found that while most participants improved in terms of functionality and independence, only a small percentage exhibited a significant change in postural sway. Therefore, postural sway may not effectively serve as an indicator of improved movement quality. This insight is crucial for both researchers and clinicians involved in neurorehabilitation.
The top 50 most cited articles in carpometacarpal arthritis: A bibliometric analysis
Authors: Zieminski Colin , Pottanat Paul , Allen J. Ryan , Daly Charles 
Published: February 2025

Background:
Carpometacarpal (CMC) arthritis is common and can be debilitating and disabling for patients. While a common pathology, treatment may vary. Understanding the current literature and evidence regarding therapy is paramount. This study analyzed the most prolific studies, authors, and journals regarding CMC arthritis. We predict they will be in hand journals from academic institutions in the U.S. by fellowshiptrained hand surgeons.

Methods:
The Elsevier Scopus database was queried for articles related to carpometacarpal arthritis. Search results were filtered by citations. The top 50 articles were reviewed, and multiple data points were collected. Citation density and h-index were identified for the articles and high producing authors.

Results:
The search yielded 1,288 articles from 1920-2024. The articles ranged from years 1968 to 2017. These papers were cited 6,608 times, ranging from 69 to 706 and averaged 132 citations. The average citation density was 5.3. The most prolific institution was Columbia University (n=6). Authors with the most publications were R.G Eaton (n=8), R.I Burton (n=5) and V.D Pellegrini (n=5). The U.S. produced the most articles (n=36). The Journal of Hand Surgery published the most articles with 20. The most common level of evidence was IV and case series was the most used type of study.

Conclusion:
Highly cited papers on carpometacarpal arthritis were most likely case series produced in the United States from a few institutions that evaluated postoperative outcomes of surgical techniques. The list provides a group of highly impactful papers that can be included in a curriculum for surgical trainees.
Society of Critical Care Medicine 2024 Guidelines on Adult ICU Design
Authors: Hamilton D. Kirk , Gary Jodie C. , Scruth Elizabeth , Anderson Harry L. , Cadenhead Charles D. , Oczkowski Simon J. , Lau Vincent I. , Adler Jason , Bassily-Marcus Adel , Bassin Benjamin S. , Boyd Joel , Busl Katharina M. , Crabb James R. , Harvey Clifford , Hecht Jason P. , Herweijer Milee , Gunnerson Kyle J. , Ibrahim Abdullahi S. , Jabaley Craig S. , Kaplan Lewis J. , Monchar Sarah , Moody Andrew , Read Julie Lindeman , Renne B. Christian , Sarosi Michael G. , Swoboda Sandra M. , Thompson-Brazill Kelly A. , Wells Chris L. , Anderson Diana C. 
Published: February 2025

Rationale:
Advances in technology, infection control challenges—as with the COVID-19 pandemic—and evolutions in patient- and family-centered care highlight ideal aspects of ICU design and opportunities for enhancement.

Objectives:
To provide evidence-based recommendations for clinicians, administrators, and healthcare architects to optimize design strategies in new or renovation projects.

Panel Design:
A guidelines panel of 27 members with experience in ICU design met virtually from the panel’s inception in 2019 to 2024. The panel represented clinical professionals, architects, engineers, and clinician methodologists with expertise in developing evidence-based clinical practice guidelines. A formal conflict of interest policy was followed throughout the guidelines-development process.

Methods:
Embase, Medline, CINAHL, Central, and Proquest were searched from database inception to September 2023. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to determine certainty in the evidence and to formulate recommendations, suggestions, and practice statements for each Population, Intervention, Control, and Outcomes (PICO) question based on quality of evidence and panel consensus. Recommendations were provided when evidence was actionable; suggestions, when evidence was equivocal; and practice statements when the benefits of the intervention appeared to outweigh the risks, but direct evidence to support the intervention did not exist.

Results:
The ICU Guidelines panel issued 17 recommendations based on 15 PICO questions relating to ICU architecture and design. The panel strongly recommends high-visibility ICU layouts, windows and natural lighting in all patient rooms to enhance sleep and recovery. The panel suggests integrated staff break/respite spaces, advanced infection prevention features, and flexible surge capacity. Because of insufficient evidence, the panel could not make a recommendation around in-room supplies, decentralized charting, and advanced heating, ventilation, and air conditioning systems.

Conclusions:
This ICU design guidelines is intended to provide expert guidance for clinicians, administrators, and healthcare architects considering erecting a new ICU or revising an existing structure.
The Definition of the Intensivist in the Era of Global Healthcare: 2024 Consensus Statement From the Society of Critical Care Medicine Defining Intensivist Task Force
Authors: Wu Daniel , Dzierba Amy L. , Ablordeppey Enyo A. , Dorman Todd , Du Bin , Dulu Alina O. , Gunnerson Kyle , Holly Pamela B. , Jansen van Rensburg Johannes , Kortz Teresa B. , Livesay Sarah L. , Lorenzo Javier , Madden Maureen A. , Mathur Piyush , Myatra Sheila Nainan , Roberts Kathryn E. , Rodríguez-Vega Gloria M. , Szakmany Tamas , Taha Ahmed , Tisherman Samuel A. 
Published: February 2025

Objectives:
The goal of this task force was to examine the 1992 definition of the intensivist, identify gaps, and initiate a path forward to define a concise and practical definition that could be applied globally.

Design:
A modified Delphi technique was used to develop a revised definition and roles of the intensivist. We determined a priori that 75% or greater participant agreement for the definition and essential roles of the intensivist was required.

Setting:
A task force consisting of physicians, a respiratory therapist, advanced practice providers, and a pharmacist that practice in critical/intensive care medicine, in various settings, was established with the goal of evaluating and revising the previous definition considering evolving healthcare.

Subjects:
The task force participated in online questionnaires related to the definition and roles of the intensivist.

Interventions:
None.

Measurements and Main Results:
The task force agreed on the following definition of an intensivist: “A physician who has successfully completed an accredited program or equivalent critical care/intensive care medicine training and maintains advanced certification (if available); and shows dedication to the area of critical/intensive care medicine in the way of professional work.” Additionally, the task force determined a list of essential roles of the intensivist categorized into Direct Clinical Care, Unit Management/Unit Involvement, Responsibility to the Community, and Administration and Leadership.

Conclusions:
The revised definition of the intensivist seeks to integrate the intensivist in the current realm of team-based healthcare. The intensivist is a physician who provides care to critically ill patients in collaboration with an interprofessional team. Establishment of a single, revised definition is intended to render clarity of an intensivist’s role and responsibilities for patients, families, and the interprofessional team.
The burden of prostate cancer and metastatic prostate cancer in Italy in 2024
Authors: Crocetti Emanuele , Ravaioli Alessandra , Falcini Fabio , Vattiato Rosa , Mancini Silvia , Baldacchini Flavia , Zamagni Federica , Vitali Benedetta , Balducci Chiara , Bucchi Lauro , Giuliani Orietta 
Published: February 2025

Objective
The epidemiologic scenario of prostate cancer (PC) is changing rapidly. The present study updates to 2024 the estimates of PC in Italy, including incident and prevalent cases, deaths, and metastatic PC (mPC), which is further subdivided into de novo mPC (metastasis detected at diagnosis) and recurrent mPC (metachronous metastasis).

Methods
The study was based on updated data from the Italian Network of Cancer Registries and the National Institute of Statistics and the age-specific short-term PC projections made available by the International Agency for Cancer Research. For mPC, we applied the age-specific ratios between deaths and estimated de novo and recurrent mPCs for the USA to the Italian age-specific deaths.

Results
In Italy, in 2024, we expect 8400 PC deaths, approximately 39 000 new diagnoses, 4900 of whom are diagnoses of mPC, and almost 670 000 prevalent cases, about 36 000 of whom are mPCs.

Conclusion
These estimates provide updated and realistic information to policy makers, clinicians, and the community to properly address the needs of patients with PC in Italy from diagnosis to end-of-life care.
Safety and Performance of RHA4 in the Midface Using the Multilayering Technique: Preclinical and Clinical Evidence
Authors: Flégeau Killian , Ballarini Stefania , Brusini Romain , Vantou Camille , Liao Zhifeng , Hirt-Burri Nathalie , Bourdon François , Tseng Fang-Wen , Faivre Jimmy 
Published: February 2025

Background:
Resilient hyaluronic acid (RHA) fillers are used to treat dynamic wrinkles or provide tissue lifting in facial aesthetics. This study explored the biological, biomechanical, and clinical safety and performance of RHA4, a volumizing hyaluronic acid filler tailored for tissue support in dynamic facial areas, upon interaction with human subcutaneous adipose tissue (AT).

Methods:
RHA4 underwent cytocompatibility testing with human fibroblasts and adipose stem cells. A 1-year rat in vivo implantation study tracked tissue integration, local effects, and filler degradation. Biomechanical tests assessed RHA4’s impact on subcutaneous AT mechanics. Clinical outcomes, safety, injection volumes, and techniques were evaluated in 35 patients, treated in midface deep and superficial fat compartments via a multilayering methodology. Dynamic outcomes and 2-year follow-up of RHA4 in the midface using multilayer treatments were described.

Results:
RHA4 demonstrated excellent biocompatibility and tissue integration both in vitro and in vivo, exhibiting minimal local inflammation and rapid collagen bundle formation within the filler. It integrated gradually over time and was well tolerated, allowing for increased extracellular matrix presence, neovascularization, denser collagen deposition, and AT growth. Ex vivo, RHA4 did not impede fat motion biomechanics but visibly lifted the tissue. Clinically, RHA4 proved safe and effective for lifting both deep and superficial fat compartments in the midface without affecting facial expressiveness.

Conclusions:
Preclinical and clinical evidence confirmed that RHA4 is a versatile filler capable of lifting tissue efficiently, whether deep or superficial, particularly through the multilayering treatment approach. Importantly, RHA4 preserves AT biomechanics, adapts to the dynamism of the face, and ensures natural-looking outcomes.
Emergency Department and Critical Care Use of Clevidipine for Treatment of Hypertension in Patients With Acute Stroke
Authors: Brehaut Scott S. , Roche Angelina M. 
Published: February 2025

Background and Purpose:
Clevidipine is a parenteral dihydropyridine calcium channel blocker that received Food and Drug Administration approval in 2008 for the reduction of blood pressure (BP) when oral therapy is not feasible or not desirable. Soon after approval, our institution incorporated clevidipine into protocols for the management of hypertension among acute stroke patients, based on the drug’s rapid onset of action and straightforward titration to goal. A subsequent retrospective review of its use in otherwise alteplase-eligible ischemic stroke patients with BP greater than 185/110 mm Hg (n = 32, in 2014) revealed that clevidipine in that setting demonstrated the shortest median time to BP control, the shortest median door-to-alteplase administration time, and the lowest administered volume of any parenteral antihypertensive used. As a result, clinical protocols in our institution were modified to make clevidipine first-line antihypertensive in both ischemic and hemorrhagic acute stroke. In this study, we report our institution’s experience with clevidipine in acute stroke, comprising the largest such report to date.

Methods:
We conducted a retrospective chart review of all acute stroke patients who received clevidipine in the emergency department (ED) or intensive care unit (ICU) (n = 295) for the management of clinically significant hypertension between January 1, 2015, and December 31, 2017. Metrics analyzed included target (goal) BP for thrombolysis eligibility among patients intended for lytic therapy according to stroke management guidelines in effect at the time of care.

Results:
The median time for initial parenteral antihypertensive dose to goal (DTG) BP for all ischemic stroke patients (both those intended for and those not intended for lytic therapy) with complete data (n = 71 of 204) was 15 minutes; median time for door-to-IV-alteplase administration for ischemic stroke patients with complete data (n = 14 of 34 treated patients) was 59 minutes. The median time for initial parenteral antihypertensive DTG BP for all hemorrhagic stroke patients with complete data (n = 33 of 91 treated patients) was 39 minutes.

Conclusions:
We conclude that the salutary findings of the initial small study are valid across a larger patient sample of all acute stroke types. Based on these data, clevidipine is shown to be safe, consistent, and effective in the treatment of acute hypertension in ischemic and hemorrhagic stroke events, and is a reasonable first-line treatment option for acute hypertension in this setting.
Unveiling emerging threats: Langya and Mojiang—A dance with unfamiliar foes
Authors: Nayak Snehasis 
Published: February 2025

Abstract
Langya henipavirus (LayV) and Mojiang henipavirus (MojV) are emerging zoonotic pathogens that were first identified in China in 2018 and 2012 respectively, and are classified within the Henipavirus genus. This article presents an in-depth review of LayV and MojV, focusing on their structural properties, viral entrance, and consequences for human health. The pathogenic potential of these viruses is investigated in depth as well as the current diagnostic methods for identifying LayV and MojV. Furthermore, treatment methods for controlling LayV and MojV infections are assessed, with a particular emphasis on the critical need for tailored antiviral research. This review serves as a critical resource for researchers and healthcare professionals, offering an up-to-date synthesis of knowledge on LayV and MojV while underscoring their significance in public health.
Enhancing supportive medication patient education for oncology nurses
Authors: Prosdocimo Brittni 
Published: February 2025

Abstract:
This article discusses a quality improvement project that developed and implemented supportive care medication cards to enhance patient education in outpatient oncology settings. Recognizing the challenges oncology nurses face in delivering effective education amidst the complexities of cancer treatment, the project evaluates the impact of these cards on patient understanding and adherence to prescribed therapies. Results from a trial period indicate significant improvements in both nurse workflow and patient comprehension, ultimately contributing to safer and more effective oncology care.
Breast cancer in males
Authors: Pullen Richard L. 
Published: February 2025

Abstract:
Male breast cancer (BC) is a rare but clinically significant disease, accounting for approximately 1% of all BC diagnoses. This article examines the unique risk factors, including genetic mutations (such as BRCA2), hormonal influences, and social determinants of health that contribute to the incidence of BC in males. In addition, this article highlights the need for improved awareness, targeted screening, and tailored treatment strategies to address the distinct challenges faced by male patients with BC.