bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terapi Aktivitas Kelompok untuk Menurunkan Keluhan Psikologis Pre-Menopause
Authors: Sasnitiari Ni Nyoman , Budhi Ni Gusti Made Ayu Agung 
Published: July 2022

<p align="center"><em>Menopausal syndrome has an impact on decreasing the quality of life of menopausal women. This study aims to determine the effect of group activity therapy on psychological complaints in pre-menopausal women in the city of Bogor. The design of this research is pretest-posttest with control group. Differences in psychological complaints were analyzed by the Wilcoxon test. The results of the analysis show p-value = 0.020, so it can be said that there are differences in pre-menopausal psychological complaints between before and after the intervention. Thus, it is concluded that group activity therapy can reduce pre-menopausal psychological complaints.</em></p><p><strong><em>Keywords</em></strong><em>: pre-menopause; psychological symptoms; group activity therapy</em></p><p align="center"><strong> </strong></p><p align="center"><strong>ABSTRAK</strong></p><p align="center"><strong> </strong></p><p>Sindroma menopause berdampak pada penurunan kualitas hidup perempuan menopause. Penelitian ini bertujuan untuk mengetahui pengaruh terapi aktivitas kelompok terhadap keluhan psikologis pada ibu <em>pre-menopause</em> di Kota Bogor. Rancangan penelitian ini adalah <em>pretest-posttest with control group</em>. Perbedaan keluhan psikologis dianalisis dengan uji Wilcoxon. Hasil analisis menunjukkan <em>p-value</em> = 0,020, sehingga dapat dikatakan ada perbedaan keluhan psikologis <em>pre-menopause</em> antara sebelum dan ssudah intervensi. Dengan demikian disimpulkan bahwa terapi aktivitas kelompok dapat menurunkan keluhan psikologis <em>pre</em><em>-</em><em>menopause</em>.</p><p><strong>Kata kunci</strong>: pre-menopause; gejala psikologis; terapi aktivitas kelompok <strong><em></em></strong></p><p><strong><em> </em></strong></p>
Detection of Carbohydrate Antigen 50 Based on a Novel Miniaturized Chemiluminescence Analyzer Enables Large-Scale Cancer Early Screening in Grassroots Community
Authors: Liu Yu , He Xiaowei , Zou Jingjing , Ouyang Xiuyun , Huang Chunrong , Yang Xiao , Wang Yu 
Published: July 2022

Early screening of cancer can effectively prolong survival time and reduce cancer mortality. However, the existing health-monitoring devices can only be carried out in professional laboratories, so large-scale early cancer screening in resource-limited settings is hardly achieved. To embrace the challenge, we developed a novel chemiluminescence immunoassay (CLIA) analyzer that does not require a professional operation. Then, it was applied to detect carbohydrate antigen 50 (CA50), a non–organ-specific tumor marker for screening various cancers. As a result, the analyzer exhibited excellent performance that the total assay time was only 15 min, and the detection limit reached 0.057 U ml−1. A coefficient of variance (CV) less than 15% was well-controlled for both intra- and inter-assay precision, and the linear range was 0–500 U ml−1. More importantly, this analyzer can continuously detect 60 samples per hour without any professional paramedic. Finally, this analyzer has been applied to evaluate clinical samples and the detected results showed a good correlation with the clinical test results (correlation coefficient, 0.9958). These characteristics exactly meet large-scale and high-throughput early screening of cancer. Thus, this miniaturized analyzer for CA50 detection is promising to achieve early large-scale screening of cancer in the resource-limited grassroots community.
TFAP2B Haploinsufficiency Impacts Gastrointestinal Function and Leads to Pediatric Intestinal Pseudo-obstruction
Authors: Zada Almira , Kuil Laura E. , de Graaf Bianca M. , Kakiailatu Naomi , Windster Jonathan D. , Brooks Alice S. , van Slegtenhorst Marjon , de Koning Barbara , Wijnen René M. H. , Melotte Veerle , Hofstra Robert M. W. , Brosens Erwin , Alves Maria M. 
Published: July 2022

Background: Pediatric Intestinal Pseudo-obstruction (PIPO) is a congenital enteric disorder characterized by severe gastrointestinal (GI) dysmotility, without mechanical obstruction. Although several genes have been described to cause this disease, most patients do not receive a genetic diagnosis. Here, we aim to identify the genetic cause of PIPO in a patient diagnosed with severe intestinal dysmotility shortly after birth.Methods: Whole exome sequencing (WES) was performed in the patient and unaffected parents, in a diagnostic setting. After identification of the potential disease-causing variant, its functional consequences were determined in vitro and in vivo. For this, expression constructs with and without the causing variant, were overexpressed in HEK293 cells. To investigate the role of the candidate gene in GI development and function, a zebrafish model was generated where its expression was disrupted using CRISPR/Cas9 editing.Results: WES analysis identified a de novo heterozygous deletion in TFAP2B (NM_003221.4:c.602-5_606delTCTAGTTCCA), classified as a variant of unknown significance. In vitro studies showed that this deletion affects RNA splicing and results in loss of exon 4, leading to the appearance of a premature stop codon and absence of TFAP2B protein. Disruption of tfap2b in zebrafish led to decreased enteric neuronal numbers and delayed transit time. However, no defects in neuronal differentiation were detected. tfap2b crispants also showed decreased levels of ednrbb mRNA, a downstream target of tfap2b.Conclusion: We showed that TFAP2B haploinsufficiency leads to reduced neuronal numbers and GI dysmotility, suggesting for the first time, that this gene is involved in PIPO pathogenesis.
Fe3O4-Fused Magnetic Air Stone Prepared From Wasted Iron Slag Enhances Denitrification in a Biofilm Reactor by Increasing Electron Transfer Flow
Authors: Wu Yifeng , Liu Xiangru , Wang Qi , Han Dongxu , Lin Shanshan 
Published: July 2022

nFe3O4 was prepared from waste iron slag and loaded onto air stone (named magnetic air stone or MAS in the following text). The main component of air stone is carborundum. To study the magnetic effects of MAS on denitrification, a biofilm reactor was built, and its microbial community structure and electron transfer in denitrification were analyzed. The results showed that MAS improved the performance of the reactor in both carbon and nitrogen removal compared with air stone (AS) control, and the average removal efficiencies of COD, TN, and NH4+-N increased by 17.15, 16.1, and 11.58%, respectively. High-throughput sequencing revealed that magnetism of MAS had a significant effect on the diversity and richness of microorganisms in the biofilm. The MAS also reduced the inhibition of rotenone, mipalene dihydrochloride (QDH), and sodium azide on the respiratory chain in denitrification and enhanced the accumulation of nitrite, in order to provide sufficient substrate for the following denitrification process. Therefore, the denitrification process is accelerated by the MAS. The results allowed us to deduce the acceleration sites of MAS in the denitrification electron transport chain.The existence of MAS provides a new rapid method for the denitrifying electron transport process. Even in the presence of respiratory inhibitors of denitrifying enzymes, the electron transfer acceleration provided by MAS still exists objectively. This is the mechanism through which MAS can restore the denitrification process inhibited by respiratory inhibitors to a certain extent.
Features and Formation Mechanism of the Jiaopenba Landslide, Southwestern Sichuan Province, China
Authors: Shen Tong , Wang Yunsheng , Zhao Xun , Liu Heng , Wu Xuyang , Chu Yapei , Zhai Panpan , Han Yang 
Published: July 2022

The Jiaopenba landslide, which represents a typical large basalt high-speed remote landslide, is located in Emeishan City, southwestern Sichuan province, China. Based on the field investigation, the characteristics of the Jiaopenba landslide have been revealed. The Jiaopenba landslide occurred on the steep Mount Emei. Landslide materials with a volume of approximately 6.75×108 m3 slid down from a high position, forming a large-scale high-speed remote debris flow, with the farthest sliding distance of about 7.5 km. The landslide area is located in the west wing of the Emeishan anticline, which is cut by faults to form a monoclinal fault-block mountain. Although the shear outlet of the landslide is near the slope toe and does not have good free conditions, there are faults passing through the slope toe of the bedding slope of the fault hanging wall, the landslide is affected by the fault activity, and the integrity of the layered slope is poor. When the foot of the slope is empty, the fault zone is compressed and plastic extrusion, which leads to bedding slip of the slope rock mass and greatly weakens the interlayer bonding force. When coupled with long structural planes on both sides to form side crack planes, a large-scale inclined plate structure is formed. Under the action of a strong earthquake and other external forces, the rock mass near the fault can be damaged by tension, and a large-scale high-position landslide can be formed by the mode of compression-slip-tension fracture.
A Network Meta-Analysis of the Dose–Response Effects of Dapagliflozin on Efficacy and Safety in Adults With Type 1 Diabetes
Authors: Li Yinhui , Li Hui , Dong Liming , Lin Dandan , Xu Lijuan , Lou Pengwei , Zang Deng , Wang Kai , Ma Li 
Published: July 2022

BackgroundMost patients with type 1 diabetes (T1DM) do not reach the blood glucose goal with treatment of insulin. In our research, we intended to estimate the therapeutic effect and safety of additional different doses of dapagliflozin on insulin treatment in T1DM.MethodsWe performed direct and indirect network meta-analysis using Bayesian models and graded different dosages of dapagliflozin by mixed therapy contrasts. We retrieved information from the PubMed, Embase, The Cochrane Library, Web of Science, China Biology Medicine (CBM) disc, China National Knowledge Infrastructure (CNKI), Wanfang Data, and WEIPU Data. Our research included randomized controlled trials (RCTs) including T1DM treated with insulin and additional dapagliflozin 5 mg or dapagliflozin 10 mg from January 2012 to June 2021. Thirteen RCTs with 10,701 participants were divided into three groups as below: insulin alone, dapagliflozin 5 mg + insulin, and dapagliflozin 10 mg + insulin.ResultsDapagliflozin dose-dependently exhibited reductions in glycated hemoglobin (HbA1c), total insulin daily dose (TDD), and body weight. Neither dapagliflozin 5 mg nor 10 mg could induce hypoglycemia or severe hypoglycemia. However, both doses of dapagliflozin increased the incidence of diabetic ketoacidosis (DKA) and genital infection.ConclusionsDapagliflozin 10 mg could achieve a better outcome in efficacy and could not increase the risk of hypoglycemia. Although it may induce a higher risk of DKA and genital infection, there was no significant difference between dapagliflozin 10 mg and 5 mg. Our outcomes indicate that dapagliflozin 10mg has a high reliability of being graded prior as a supplementary treatment to insulin in T1DM.
A Prospective Study on Risk Factors for Acute Kidney Injury and All-Cause Mortality in Hospitalized COVID-19 Patients From Tehran (Iran)
Authors: Rostami Zohreh , Mastrangelo Giuseppe , Einollahi Behzad , Nemati Eghlim , Shafiee Sepehr , Ebrahimi Mehrdad , Javanbakht Mohammad , Saadat Seyed Hassan , Amini Manouchehr , Einollahi Zahra , Beyram Bentolhoda , Cegolon Luca 
Published: July 2022

BackgroundSeveral reports suggested that acute kidney injury (AKI) is a relatively common occurrence in hospitalized COVID-19 patients, but its prevalence is inconsistently reported across different populations. Moreover, it is unknown whether AKI results from a direct infection of the kidney by SARS-CoV-2 or it is a consequence of the physiologic disturbances and therapies used to treat COVID-19. We aimed to estimate the prevalence of AKI since it varies by geographical settings, time periods, and populations studied and to investigate whether clinical information and laboratory findings collected at hospital admission might influence AKI incidence (and mortality) in a particular point in time during hospitalization for COVID-19.MethodsHerein we conducted a prospective longitudinal study investigating the prevalence of AKI and associated factors in 997 COVID-19 patients admitted to the Baqiyatallah general hospital of Tehran (Iran), collecting both clinical information and several dates (of: birth; hospital admission; AKI onset; ICU admission; hospital discharge; death). In order to examine how the clinical factors influenced AKI incidence and all-cause mortality during hospitalization, survival analysis using the Cox proportional-hazard models was adopted. Two separate multiple Cox regression models were fitted for each outcome (AKI and death).ResultsIn this group of hospitalized COVID-19 patients, the prevalence of AKI was 28.5% and the mortality rate was 19.3%. AKI incidence was significantly enhanced by diabetes, hyperkalemia, higher levels of WBC count, and blood urea nitrogen (BUN). COVID-19 patients more likely to die over the course of their hospitalization were those presenting a joint association between ICU admission with either severe COVID-19 or even mild/moderate COVID-19, hypokalemia, and higher levels of BUN, WBC, and LDH measured at hospital admission. Diabetes and comorbidities did not increase the mortality risk among these hospitalized COVID-19 patients.ConclusionsSince the majority of patients developed AKI after ICU referral and 40% of them were admitted to ICU within 2 days since hospital admission, these patients may have been already in critical clinical conditions at admission, despite being affected by a mild/moderate form of COVID-19, suggesting the need of early monitoring of these patients for the onset of eventual systemic complications.
The Clinical Observation of Acupuncture Combined With Antiemetic Drugs in the Prevention and Treatment of CINV in Breast Cancer Patients
Authors: Kong Fanming , Wang Ziwei , Wang Na , Zhao Lu , Mei Qingyun , Yu Yongchao , Zhang Dou , Li Xiaojiang , Jia Yingjie 
Published: July 2022

ObjectiveThe present study aimed to explore the effectiveness of acupuncture combined with antiemetic drugs in prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) among breast cancer patients receiving postoperative adjuvant chemotherapy. MethodsWe retrospectively collected the clinical records of 81 postoperative breast cancer patients at our hospital from January 2021 to December 2021. These patients were divided into the acupuncture group and the control group. The efficacy of the antiemetic drugs combined with acupuncture for CINV was analysed. The primary endpoints were total, acute, and delayed nausea and vomiting grade and remission rate. Safety and overall patient quality of life were secondary endpoints.ResultsDuring the whole observation period, compared with the control group, the frequency of nausea and vomiting was decreased in the acupuncture group (P=0.034). And the ECOG-PS score in the acupuncture group was significantly improved (P=0.004). In addition, the adverse events, such as abdominal (12.2% vs. 5.0%, P=0.252), distention (19.5% vs. 5.0%, P=0.049), and diarrhea (9.7% vs. 0, P=0.044), were decreased by acupuncture.ConclusionsAcupuncture combined with antiemetics could reduce the incidence of CINV, improve the quality of life of patients and reduce the incidence of adverse side effects of antiemetic drugs.
Urethral Plate Characteristics in Cases of Non-proximal Hypospadias May Not Be Associated With a Higher Risk of Complications When a Two-Stage Repair Is Applied
Authors: Marcou Marios , Bobbe Sarah-Magdalena , Wullich Bernd , Hirsch-Koch Karin 
Published: July 2022

PurposeTo investigate whether a two-stage repair of distal- and mid-shaft hypospadias (non-proximal hypospadias) could eliminate the risk factors resulting from adverse urethral plate characteristics and eventually reduce complication rates.MethodsWe retrospectively reviewed all cases of primary surgical repair of non-proximal hypospadias performed in our center between 2009 and 2018. In all cases where adverse urethral plate characteristics were found, such as meatal stenosis, a shallow urethral groove, a thick web of tissue between the native meatus and the urethral groove or in the presence of a very “thin,” skin-like distal urethra, a two-stage repair was routinely undertaken. In cases of native meatal stenosis, a meatotomy, and meatoplasty were performed. In cases of a very “thin” distal urethra we incised the skin proximally up to the point of a normal urethral fold and a meatoplasty was performed at that point. Hypospadias repair was then performed in a second operation, 3–6 months following the first procedure. Urethroplasty, both in cases of a single-stage repair and in cases of a two-stage repair, was always performed using the Thiersch-Duplay technique. Patients with a follow-up of less than 12 months were excluded from this study.ResultsOver a period of 10 years, 208 boys underwent primary surgical repair of non-proximal hypospadias. Eighty-nine of the 208 patients (42.8%) underwent single-stage hypospadias repair. Two-stage repair of the hypospadias was required in 119 (57.2%) of the patients. The overall complication rate was 3.4% in the group operated in a single stage and 7.6% in the group that required a two-stage repair (p = 0.09). The most frequent complication reported was urethrocutaneous fistula (p = 0.31), followed by meatal stenosis (p = 0.37), urethral stricture (p = 0.08) and wound dehiscence (p = 0.16). There was no significant difference between the complication rates of the two groups.ConclusionPatients with distal hypospadias and poor urethral plate characteristics repaired in a two-stage approach have comparable low-complications to those with favorable urethral plate characteristics repaired in a single-stage.
Gaming Disorder Seen Through the Prism of Dual Diagnosis: Prevalence and Associated Factors
Authors: Barrangou-Poueys-Darlas Malcolm , Cabelguen Clémence , Garrouste Vincent , Leboucher Juliette , Rocher Bruno , Challet-Bouju Gaëlle , Grall-Bronnec Marie 
Published: July 2022

IntroductionDual diagnosis (DD) is defined as the co-occurrence of at least a psychiatric disorder and at least an addictive disorder. Most studies about DD considered substance use disorders. In 2018, gaming disorder (GD) was recognized as a formal disorder and integrated into the category of addictive disorders in the 11th version of the International Classification of Diseases. Our objectives were to measure DD prevalence among GD patients and to assess factors associated with the presence of DD.MethodsAs part of the EVALuation of behavioral ADDictions (EVALADD) cohort, 92 patients with GD were included in the present study. Psychiatric disorders, including anxiety, mood, and psychotic disorders, were explored with the Mini International Neuropsychiatric Interview (MINI 5.0.0). Probable adult attention-deficit/hyperactivity disorder (ADHD) was screened with the Wender Utah Rating Scale (WURS) in childhood and with the ADHD Self-Report Scale-V1.1 (ASRS) in adulthood. Finally, personality was assessed using the 125-item version of the Temperament and Character Inventory (TCI-125), motives for gaming with the Videogame Motives Questionnaire (VMQ) and attachment styles with the Relationship Scales Questionnaire (RSQ). To measure the prevalence of DD among GD patients, we considered the occurrence of current GD with current anxiety, mood, or psychotic disorders, or with probable current ADHD. We also performed a multivariate analysis to identify independent factors associated with DD.ResultsMore than half (55.4%) of GD patients suffered from DD. We found a high prevalence of probable ADHD (38%) and anxiety disorders (29% suffering from generalized anxiety disorder, social, agoraphobia or panic disorder). Four variables were significantly associated with DD: suicidal thoughts [odds ratio (OR) = 6.83, 95% confidence interval (95%CI) (1.66–28.09)], VMQ “coping” scores [OR = 1.18, 95%CI (1.01–1.38)], TCI-125 “harm avoidance” scores [OR = 1.04, 95%CI (1.01–1.07)] and “novelty seeking” scores [OR = 1.03, 95%CI (1.00–1.06)].DiscussionThe prevalence of certain psychiatric disorders among GD patients far exceeded that observed in the general population. Both ADHD and suicidal ideations should particularly be screened among GD patients. Specific interventions targeting personality dimensions associated with DD but also on the management of negative affect should represent new treatment opportunities.
Leader Humility, Sense of Power, and Interpersonal Deviance Relationship Model in the Bureaucratic Culture
Authors: Hadmar Ambo Sakka , Hendryadi Hendryadi , Suratna Suratna , Karyatun Subur 
Published: July 2022

PurposeDrawing on the approach—inhibition theory of power and the containment theory of control—we propose a relationship model of leader humility, sense of power, and interpersonal deviance, by placing bureaucratic culture as a boundary condition.Design/Methodology/ApproachUsing a moderated mediation model, this study applies hierarchical regression and bootstrapping analyses to data obtained from online questionnaire responses of 428 employees from various sectors in Indonesia.FindingsThe results reveal a positive relationship between leader humility and employees perceptions of the sense of power, as well as between the sense of power to interpersonal deviance. In addition, we confirmed the mediating role of the sense of power on the relationship between leader humility and interpersonal deviant. Bureaucratic culture has been confirmed to moderate the relationship between a sense of power and interpersonal deviance.Practical ImplicationsCompanies can provide leadership training to leaders to convey to them when and where to demonstrate humility. Furthermore, the effectiveness of leaders' humility can be increased and their sense of power and interpersonal deviance reduced if the company adopts a low-level bureaucratic culture.Originality/ValueThe current study contributes to the extant literature by revealing the moderating effects of bureaucratic culture on the relationship between the sense of power and interpersonal deviance, clarifying how, and when employees' sense of power stimulates interpersonal deviance in the Asian context.