bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delay of initial radioactive iodine therapy beyond 3 months has no effect on clinical responses and overall survival in patients with thyroid carcinoma: A cohort study and a meta‐analysis
Authors: Cheng Fang , Xiao Juan , Huang Fengyan , Shao Chunchun , Ding Shouluan , Yun Canhua , Jia Hongying 
Published: February 2022

AbstractBackgroundMore than a third of thyroid carcinoma (TC) patients require treatment with radioactive iodine (RAI), but the timing of initial RAI therapy after thyroidectomy remains controversial.MethodsWe included 1224 differentiated thyroid carcinoma (DTC) patients during 2015–2019, divided them into the early (≤3 months) and the delayed (>3 months) groups based on the interval between surgery and the initial RAI. Clinical outcomes were assessed within 6–8 months of treatment with RAI, including excellent response (ER), indeterminate response (IDR), biochemical incomplete (BIR) and structural incomplete response (SIR). Further transformed them into dichotomous outcomes, we therefore introduced the ordered/binary logistic regression to assess the relation of time interval and quaternary/dichotomous outcomes, respectively. Finally, we conducted a meta‐analysis for cohort study to investigate the effect of timing of RAI therapy on the prognosis of TC.ResultsDelay RAI therapy beyond 3 months reduced the IR (BIR + SIR) rate in the present cohort study (RR = 0.67, 95% CI: 0.49–91). Following meta‐analysis including 38,688 DTC patients confirmed these results (RR = 0.77, 95% CI: 0.66–0.91), further revealed the duration of treatment does not influence OS (pooled RR = 1.05, 95% CI: 0.83–1.33).ConclusionDelayed initial RAI therapy beyond 3 months but no later than 6 months did not impair the prognosis of TC.
CCL2 activates AKT signaling to promote glycolysis and chemoresistance in glioma cells
Authors: Qian Yafang , Ding Peng , Xu Jie , Nie Xiaohu , Lu Bin 
Published: February 2022

AbstractThe incidence of gliomas is increasing. Although great progress in glioma treatment has been made, the clinical outcome remains unsatisfactory. Chemokine (C‐C motif) ligand 2 (CCL2) plays a key role in different types of cancers, including glioma. However, the function of CCL2 in glioma chemoresistance is not fully understood. In the current study, CCL2 was significantly upregulated in glioma. More importantly, CCL2 and CCR2 were significantly upregulated in temozolomide (TMZ)‐resistant glioma. TMZ‐resistant malignant glioblastoma cells (U251/TMZ) had higher expressions of CCL2 and CCR2 and a higher level of glycolysis as compared to its parental cell line U251. Silencing of CCL2 in U251/TMZ cells inhibited glycolysis. Overexpression of CCL2 reduced TMZ‐induced apoptosis through activation of the AKT pathway and promotion of glycolysis. Moreover, overexpression of CCL2 significantly reduced the antitumor effect of TMZ in vivo. In conclusion, CCL2 overexpression reduced the antitumor effect of TMZ by enhancing glycolysis through activation of AKT signaling. The findings highlighted the importance of CCL2/CCR2/glycolysis and its potential value in developing new treatment for glioma.
Fungal, parasitological, and bacterial coinfection in a severely ill COVID‐19 patient in Peru
Authors: Moya‐Salazar Jeel , Sauñe Sharon S. , Valer Roxana , Salazar‐Hernandez Richard , Loza Wilfredo , Suxe Evelyn , Chicoma‐Flores Karina , Contreras‐Pulache Hans 
Published: February 2022

AbstractCOVID‐19 patients are prone to coinfections during their hospitalization. These coinfections are challenging as they involve longer hospital stays, high costs, and higher risk of mortality. Here, we present a case of a patient with multi‐infection by resistant parasites, fungi, and bacteria during his hospitalization in a hospital in Lima, Peru.
Slow‐growing pedunculated nodule
Authors: Kouki Chaima , Kammoun Nadine , Sellami Khadija , Bahloul Emna , Mallouli Manel , Ayadi Lobna , Boudaouara Tahya , Turki Hamida 
Published: February 2022

AbstractThere have been limited reported cases of pedunculated basal cell carcinoma(BCC). Our case is original, and it combines two rare aspects of CBC: Pedunculated and giant. This uncommon aspect is rarely encountered.
The roles of between‐ and within‐person self‐knowledge in career decision‐making
Authors: Xu Hui 
Published: February 2022

AbstractWhile social comparison is likely a common practice in career decision‐making, little is known about whether the knowledge products of such comparisons are beneficial and the extent to which they are beneficial. Using a sample of U.S. individuals (n = 296), the current study examined the unique and multiplicative predictions of between‐person self‐knowledge (i.e., knowledge about the relative standings of attributes in society) and within‐person self‐knowledge (i.e., knowledge about the dominant areas within psychological profiles) for career decision‐making difficulty. The results revealed that between‐person self‐knowledge negatively predicted choice/commitment anxiety. The results also supported the positive moderation of between‐person self‐knowledge in the prediction of within‐person self‐knowledge for choice/commitment anxiety. In general, the present study suggests that between‐person self‐knowledge is an important assessment and intervention area that is auxiliary to within‐person self‐exploration in facilitating career decision‐making.
Linker‐Modulated Peroxide Electrosynthesis Using Metal‐Organic Nanosheets**
Authors: Kuruvinashetti Kiran , Kornienko Nikolay 
Published: February 2022

AbstractThe electrochemical synthesis of hydrogen peroxide (H2O2), a widely used oxidant, is emerging as a green alternative to the conventional anthraquinone method. In this work, Ni‐based metal‐organic nanosheet (Ni−MON) catalysts constructed using a variety of linkers were studied as oxygen reduction catalysts. Using a host of analytical techniques, we reveal how modulating the terephthalic acid linker with hydroxy, amine, and fluorine groups impacts the resulting physical and electronic structure of the Ni catalytic sites. These changes further impact the catalysts’ Faradaic Efficiency for H2O2, with the Ni−Amine−MON reaching near 100 % FE at minimal overpotential for the 2e− H2O2 pathway in alkaline electrolyte. Finally, we translate the Ni−Amine−MON catalyst to a gas‐diffusion reaction geometry and demonstrate a H2O2 partial current density of 200 mA/cm2 while maintaining 85 % Faradaic efficiency. In all, this study puts forth a simple route to catalyst modulation for highly effective H2O2 electrosynthesis.
Applicability of TiO2‐Laden Asphalt Pavements in Reducing the Vehicular Pollution of Chandigarh, India
Authors: Singh Harjinder , Thind Parteek Singh , Singh Sandeep , John Siby 
Published: February 2022

AbstractVehicular emissions play a significant role in urban‐environmental pollution. Therefore, in the present investigation, efforts are made to estimate the applicability of Titanium dioxide (TiO2)‐laden asphalt pavements in degrading the ambient Nitrogen Dioxide (NO2) in Chandigarh, India. In this regard, an artificial environment is created, and experiments are designed to degrade NO2 and Sulfur dioxide (SO2) using photocatalysis. Further, the process parameters, viz., concentration of TiO2 emulsion (25 to 125 mL m−2), Ultraviolet UV‐A irradiance (1 to 5 mW cm−2), and proportion of bitumen (4 to 6%), are optimized to achieve the maximum degradation of NO2 and SO2. Results reveal that maximum degradation of NO2 and SO2, that is, 61.91 and 55.39%, respectively, is achieved at 81.67 mL m−2 of TiO2 emulsion, 5 mW cm−2 of UV‐A irradiance, and 5.78% of bitumen. The optimized conditions of photocatalytic application are further used to treat the ambient NO2 of Chandigarh, India. Analysis of the ambient air data of Chandigarh, India, from 2005 to 2015, depicts significant contribution of vehicular emissions. It is also predicted that by 2031 the ambient concentration of NO2, may exceed the permissible limits. However, layering of asphalt payments with TiO2 could prevent such situation by 2114.
Institutional force and firm performance: Do employee green involvement and flexibility‐oriented culture matter?
Authors: Zhang Qiansong , Feng Taiwen , Cheng Long , He Qingsong 
Published: February 2022

AbstractDespite the increasing awareness in perceived institutional force, whether and how it affects firm performance has not been confirmed. According to stakeholder theory, this article explores how perceived institutional force influences different types of firm performance via employee green involvement, as well as the moderating role of flexibility‐oriented culture. We collect two round data from 317 Chinese manufacturers to examine the hypotheses. The findings manifest that both perceived business and social force promote employee green involvement. Employee green involvement partially mediates the effect of perceived business force on financial performance, while fully mediates the effect of perceived business force on environmental performance. Additionally, employee green involvement partially mediates the effects of perceived social force on financial and environmental performance. Our research also indicates that flexibility‐oriented culture positively moderates the impacts of perceived business and social force on employee green involvement. This research enriches the institutional force literature by verifying how and under what conditions it impacts firm performance.
Ni‐Fe Layered Double Hydroxide Nanosheets Supported on Exfoliated Graphite for Efficient Urea Oxidation in Direct Urea Fuel Cells
Authors: Zhao Xiaolong , Wang Yifei , Zhang Yingguang , Luo Shijing , Zhang Huimin , Leung Dennis Y. C. 
Published: February 2022

AbstractUrea‐rich wastewater can cause serious eutrophication problem to the water environment. On the other hand, urea is a potential fuel with high energy density, which can be effectively utilized by direct urea fuel cell. In this work, exfoliated graphite (EG) with high surface area and electrical conductivity was obtained by microwave irradiation, which was used to support the Ni−Fe layered double hydroxide (LDH), leading to a highly efficient and low‐cost urea oxidation catalyst. Compared with commercial RuO2, the as‐prepared Ni−Fe LDH/EG exhibited a lower onset potential of 1.25 V vs. reversible hydrogen electrode as well as a lower Tafel slope of 44 mV dec−1. The catalyst durability was also proved to be excellent. The optimized Ni/Fe molar ratio was confirmed to be 3 : 1, while the most suitable catalyst/EG ratio was 3 : 50. When applied in a dual‐electrolyte direct urea fuel cell, the peak power density reached 12 mW cm−2, and the long‐term discharge was also stable with negligible voltage loss at 10 mA cm−2 for 3 h. Such a low‐cost and efficient urea oxidation catalyst can be widely utilized in future direct urea fuel cells, which achieve wastewater treatment and renewable electricity generation at the same time.
A series of case studies illustrating the role of flow cytometry in the diagnostic work‐up of myelodysplastic syndromes
Authors: Westers Theresia M. , Saft Leonie , van der Velden Vincent H. J. , te Marvelde Jeroen G. , Dunlop Alan , Ireland Robin , Valent Peter , Porwit Anna , Béné Marie C. , van de Loosdrecht Arjan A. 
Published: February 2022

AbstractCurrent guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work‐up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision‐making in inconclusive and clinically ‘difficult’ cases.
The Wnt1‐Cre2 transgene is active in the male germline
Authors: Dinsmore Colin J. , Ke Chen‐Yeh , Soriano Philippe 
Published: February 2022

SummaryThe Wnt1‐Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WNT1 itself, which can cause undesired phenotypes. To address this, we and others previously developed a Wnt1‐Cre2 line based on the same regulatory elements as Wnt1‐Cre but without ectopic Wnt1 expression. However, while Wnt1‐Cre2 exhibits normal activity when transmitted from female mice, it exhibits unexpected activity in the male germline. The Wnt1‐Cre2 transgene was previously mapped to the E2f1 locus. Several genes in this genomic region exhibit significant expression in spermatogonia or spermatocytes, suggesting that local regulatory elements may be driving ectopic transgene expression. The Wnt1‐Cre2 line can therefore be used both as a neural crest specific and a general deleter, and care should be taken when setting up genetic crosses.
Fungal spore transport by omnivorous mycophagous slug in temperate forest
Authors: Kitabayashi Keiko , Kitamura Shumpei , Tuno Nobuko 
Published: February 2022

AbstractSlugs are important consumers of fungal fruiting bodies and expected to carry their spores. In this study, we examined whether slugs (Meghimatium fruhstorferi) can act as effective dispersers of spores of basidiomycetes. The microscopic observation confirmed the presence of basidiospores in feces of field‐collected slugs, and the DNA metabarcoding study revealed that Ascomycota and Basidiomycota were major fungal taxa found in the feces. In Basidiomycota, the dominant order was Agaricales followed by Trichosporonales and Hymenochaetales. The laboratory experiments using Tylopilus vinosobrunneus showed that slugs carried a large number of spores in their digestive tracts. It was also observed that Pleurotus, Armillaria, and Gymnopilus spores excreted by slugs had a higher germination capacity than control spores collected from spore prints. The field experiments showed that slugs traveled 10.3 m in 5 h at most by wandering on the ground, litter layers, wood debris, and tree trunks. These results suggest that slugs could carry spores of ectomycorrhizal, saprophytic, and wood‐decaying fungi to appropriate sites for these fungi to establish colonies.
Clinical features and predictors of atrial fibrillation in patients with light‐chain or transthyretin cardiac amyloidosis
Authors: Papathanasiou Maria , Jakstaite Aiste‐Monika , Oubari Sara , Siebermair Johannes , Wakili Reza , Hoffmann Julia , Carpinteiro Alexander , Hagenacker Tim , Thimm Andreas , Rischpler Christoph , Kessler Lukas , Rassaf Tienush , Luedike Peter 
Published: February 2022

AbstractAimsThe study aimed to investigate the prevalence, phenotypic characteristics, and predictors of atrial fibrillation (AF) in patients presenting with cardiac amyloidosis (CA) of light‐chain (AL) or transthyretin (ATTR) type.Methods and resultsClinical, biochemical, and echocardiographic data of patients presenting with CA between 2005 and 2020 were retrospectively collected. CA staging was based on established biomarker systems. Binomial logistic regression was run to analyse the effects of clinical variables on the likelihood of AF. The study included 133 patients [53% AL, 41% wild‐type (wt) ATTR‐CA, & 6% hereditary ATTR‐CA]. Mean age was 71 years, and 80% were male patients. AF was diagnosed in 64 (48%) patients (28% in AL‐CA, 80% in wtATTR, 13% in hATTR, P < 0.001). Patients with AF were older (74 vs. 69 years, P < 0.001), more likely to have wtATTR‐CA (67 vs. 16%, P < 0.001), exhibited more often New York Heart Association ≥ III symptoms (66 vs. 45%, P = 0.02) and carried a higher burden of comorbidities. AF patients had lower left ventricular ejection fraction (47 vs. 53%, P < 0.005), higher left atrial volume index (54 vs. 46 mL/m2, P = 0.007), higher pulmonary artery pressure (42 vs. 31 mmHg, P = 0.008), and worse tricuspid annular plane systolic excursion values (17 vs. 20 mm, P = 0.01). Mitral regurgitation ≥ Grade 2 was more frequent in AF (56 vs. 25%, P < 0.001). Higher ATTR‐CA stage was associated with higher AF prevalence (47% vs. 74% vs. 94%, P < 0.001, for Stages I, II, & III, respectively). Higher AL‐CA stage was associated with lower AF prevalence (0% vs. 40% vs. 31% vs. 18%, P < 0.001, for Stages I, II, IIIa, & IIIb, respectively). Three independent predictors for AF were identified in a multivariate logistic regression model with 81.5% classification accuracy: AL type [odds ratio (OR) 0.1, confidence interval (CI) 0.01–0.29, P = 0.001], estimated glomerular filtration rate (OR 0.9, CI 0.93–0.99, P = 0.03), and body mass index (OR 1.3, CI 1.07–1.66, P = 0.01). ATTR amyloidosis was associated with a 10‐fold higher risk of AF. During 1 year follow‐up, only one episode of ischaemic stroke was reported.ConclusionsAtrial fibrillation affects nearly half of all patients with CA. Patients presenting with AF have more severe symptoms and higher burden of comorbidities. ATTR type of amyloidosis is the strongest predictor of AF. Prospective screening for occult AF may be considered in ATTR‐CA.
Organocatalytic Dynamic Kinetic Resolution: An Update
Authors: Pellissier Hélène 
Published: February 2022

AbstractIt is only in the two last decades that the first examples of organocatalytic dynamic kinetic resolutions (DKRs) have been disclosed. These methodologies allow resolving racemic compounds with up to quantitative yield. Today, a variety of chiral organocatalysts are capable of providing excellent enantioselectivities in many types of transformations evolving through DKR. The goal of this review is to update the field of organocatalytic DKRs since 2016. It is divided into six sections, according to the different types of organocatalysts employed in these reactions, such as Brønsted acid catalysts, hydrogen‐bonding catalysts, N‐heterocyclic carbene catalysts, Lewis base catalysts, phase‐transfer catalysts, and cinchona alkaloid‐based Brønsted base catalysts.
Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores
Authors: Abdulkadir Mohamed , Hübel Christopher , Herle Moritz , Loos Ruth J. F. , Breen Gerome , Bulik Cynthia M. , Micali Nadia 
Published: February 2022

AbstractBackgroundEating disorder (ED) symptoms are prevalent in the general population, but their shared genetic underpinnings with psychiatric, metabolic, and anthropometric traits are not known. Here, we examined if polygenic scores (PGSs) of traits associated with anorexia nervosa are also associated with adolescent ED symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC).MethodsA total of 8654 participants with genotype data and at least one phenotypic measure were included from the ALSPAC study. We associated PGS from 25 traits (16 psychiatric, 4 metabolic, and 5 anthropometric) with eight ED symptoms, including behaviours such as fasting for weight loss and cognitions such as body dissatisfaction.ResultsHigher attention deficit hyperactivity disorder PGS and lower educational attainment PGS were associated with fasting for weight loss. Higher insomnia PGS was associated with increased body dissatisfaction. We found no evidence of an association between metabolic trait PGS and any ED symptom. Fat‐free mass, fat mass, and body fat percentage PGSs, were positively associated with binge eating, excessive exercise, fasting for weight loss, body dissatisfaction, and weight and shape concern.ConclusionsED symptoms are genetically associated with psychiatric and anthropometric, but not with metabolic traits. Our findings provide insights for future genetic research investigating on why some individuals with ED symptoms progress to develop threshold EDs while others do not.
Discrete choice analysis of health worker job preferences in Ethiopia: Separating attribute non‐attendance from taste heterogeneity
Authors: Arora Nikita , Quaife Matthew , Hanson Kara , Lagarde Mylene , Woldesenbet Dorka , Seifu Abiy , Crastes dit Sourd Romain 
Published: February 2022

AbstractWhen measuring preferences, discrete choice experiments (DCEs) typically assume that respondents consider all available information before making decisions. However, many respondents often only consider a subset of the choice characteristics, a heuristic called attribute non‐attendance (ANA). Failure to account for ANA can bias DCE results, potentially leading to flawed policy recommendations. While conventional latent class logit models have most commonly been used to assess ANA in choices, these models are often not flexible enough to separate non‐attendance from respondents' low valuation of certain attributes, resulting in inflated rates of ANA. In this paper, we show that semi‐parametric mixtures of latent class models can be used to disentangle successfully inferred non‐attendance from respondent's “weaker” taste sensitivities for certain attributes. In a DCE on the job preferences of health workers in Ethiopia, we demonstrate that such models provide more reliable estimates of inferred non‐attendance than the alternative methods currently used. Moreover, since we find statistically significant variation in the rates of ANA exhibited by different health worker cadres, we highlight the need for well‐defined attributes in a DCE, to ensure that ANA does not result from a weak experimental design.
Dynamic risk profiling of HCC recurrence after curative intent liver resection
Authors: Ivanics Tommy , Murillo Perez Carla Fiorella , Claasen Marco P. A. W. , Patel Madhukar S. , Morgenshtern Gabriela , Erdman Lauren , Shwaartz Chaya , Rajendran Luckshi , O’Kane Grainne M. , Hansen Bettina E. , Cleary Sean P , Sapisochin Gonzalo 
Published: February 2022

Abstract

Background and Aims
Following liver resection (LR) for HCC, the likelihood of survival is dynamic, in that multiple recurrences and/or metastases are possible, each having variable impacts on outcomes. We sought to evaluate the natural progression, pattern, and timing of various disease states after LR for HCC using multistate modeling and to create a practical calculator to provide prognostic information for patients and clinicians.

Approach and Results
Adult patients undergoing LR for HCC between January 2000 and December 2018 were retrospectively identified at a single center. Multistate analysis modeled post‐LR tumor progression by describing transitions between distinct disease states. In this model, the states included surgery, intrahepatic recurrence (first, second, third, fourth, fifth), distant metastasis with or without intrahepatic recurrence, and death. Of the 486 patients included, 169 (34.8%) remained recurrence‐free, 205 (42.2%) developed intrahepatic recurrence, 80 (16.5%) developed distant metastasis, and 32 (7%) died. For an average patient having undergone LR, there was a 33.1% chance of remaining disease‐free, a 31.0% chance of at least one intrahepatic recurrence, a 16.3% chance of distant metastasis, and a 19.8% chance of death within the first 60 months post‐LR. The transition probability from surgery to first intrahepatic recurrence, without a subsequent state transition, increased from 3% (3 months) to 17.4% (30 months) and 17.2% (60 months). Factors that could modify these probabilities included tumor size, satellite lesions, and microvascular invasion. The online multistate model calculator can be found on https://multistatehcc.shinyapps.io/home/.

Conclusions
In contrast to standard single time‐to‐event estimates, multistate modeling provides more realistic prognostication of outcomes after LR for HCC by taking into account many postoperative disease states and transitions between them. Our multistate modeling calculator can provide meaningful data to guide the management of patients undergoing postoperative surveillance and therapy.