bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening Active Phytochemicals of Some Ayurvedic Medicinal Plants to
Identify Potential Inhibitors against SARS-CoV-2 Mpro by Computational
Investigation
Authors: Alagarsamy V. , Solomon V. Raja , Sulthana M. T. , Sundar P. Shyam , Aishwarya A. Dharshini , Narendhar B. 
Published: September 2022

Background:
Severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2
Mpro) is an important target for drug development amidst whole variants of coronaviruses, a vital protein
for the replication cycle of virus.

Objective:
The main aim of this study is to discover and recognize the most effective and promising molecules
against Mpro enzyme through molecular docking screening of 120 phytochemicals from six different
Ayurveda medicinal plants.

Methods:
The phytochemicals were downloaded from PubChem, and SARS-CoV-2 Mpro was taken from
the protein data bank. The molecular interactions, binding energy, and ADMET properties were analyzed.

Results:
Molecular docking analysis identified 10 phytochemicals, castalagin (-10.4 kcal/mol),
wedelolactone (-8.0 kcal/mol), arjungenin (-7.7 kcal/mol), betulin (-7.7 kcal/mol), galbacin (-7.6
kcal/mol), shinpterocarpin (-7.6 kcal/mol), liquirtin (-7.4 kcal/mol), cordioside (-7.3 kcal/mol), licopyranocoumarin
(-7.3 kcal/mol), and daucosterol (-7.1 kcal/mol) from different kinds of ayurvedic medicinal
plants’ phytochemicals possessing greater affinity against Mpro of SARS-CoV-2. Two molecules, namely
castalagin and wedelolactone, with low binding energies were the most promising. Furthermore, we carried
out MD simulations for the castalagin complexes based on the docking score.

Conclusion:
Molecular ADMET profile estimation showed the docked phytochemicals to be safe. The
present study suggested that active phytochemicals from medicinal plants could inhibit Mpro of SARSCoV-
2.
Chemistry of gem-Difluorovinyl Sulfonates
Authors: Zhang Cai 
Published: September 2022

Abstract:
Among various emerging organofluorine molecules, gem-difluorovinyl sulfonates are attractive
building blocks and less used in organic reactions. This review article is concerned with recent
advances in organic reactions using gem-difluorovinyl sulfonates in recent years. We discussed the
reactions of gem-difluorovinyl sulfonates with aldehydes, amines, imines, amides, boronic acids, aryl
halides, etc. or addition, reduction, substitution and intramolecular 1,3-sulfonyl migration of gemdifluorovinyl
sulfonates in nine approaches. The synthetic strategies described in this review provided
diversely substituted fluorinated molecules.
Efficacy and Safety of MRI and CT Guided VX2 Hepatic Para-vascular
Tumor Model in Rabbits
Authors: Feng Xu , Das Sushant K. , Feng Gui-Ling , Liu Yan , Liu Ying , Li Bing , Du Yong 
Published: September 2022

Objective:
To compare the efficacy and safety of 1.5 T MRI and CT guided VX2 hepatic para-vascular tumor model in rabbits.

Materials and Methods:
Sixty New Zealand white rabbits were randomly and equally divided into MRI-guided group (n=30) and CT-guided group (n=30). Rabbit VX2 tumor fragments were implanted beside the rabbit hepatic great vessels under MRI and CT-guidance in the MRI and CT group respective, to evaluate the success rate of tumor model establishment, puncture needle display and tip peripheral vascular situation, operation time and safety.

Results:
In MRI-guided group, 29 rabbits (29/30, 96.7%) had successful establishment of liver tumor model, 1 rabbit had needle metastasis. In CT-guided group, 24 rabbits (24/30, 80%) had successful establishment of liver tumor model while 2 rabbits had needle metastasis, 3 rabbits had metastases in other parts of the liver, and 1 had unknown cause of death. The differences in success rate of tumor model establishment between the two groups were statistically significant (χ2 = 4.043, P < 0.05). The fold number of artifacts at T1WI was 7.26±0.38 for the 20 G coaxial puncture needle in the MRI-guided group and 2.51±0.57 for the 20 G coaxial puncture needle in the CT-guided group, and the difference was statistically significant (t=36.76, P < 0.001), but star-shaped hypodense artifacts would appear around the needle tip. The operation time was longer in the MRI-guided group than in the CT-guided group (13.32±2.45 minutes in the MRI-guided group vs 8.42±1.46 minutes in the CT-guided group; t=9.252, P < 0.001). A small number of ascites occurred in 2 patients (2/30, 6.67%) in the CT-guided group; no serious complications such as liver abscess, jaundice or diaphragmatic perforation were observed in both groups.

Conclusion:
Compared with CT, MRI-guided hepatic para-vascular tumor implantation in rabbits might be a more effective modeling method. Although the needle tip pseudopacity of puncture needle is large and the operation time is long, the incidence of complications is low.
Polymeric Nanoparticles: Prospective on the Synthesis, Characterization
and Applications in Nose-to-Brain Drug Delivery
Authors: Kendre Prakash N. , Kayande Dhiraj R. , Jain Shirish P. , Malge Tejaswini G. , Zadpe Namrata N. , Prajapati Bhupendra G. 
Published: September 2022

Abstract:
For the treatment of brain illnesses, there is growing interest in nose-to-brain drug administration.
Other, more traditional methods of crossing the blood–brain barrier (BBB) are ineffective.
As a result, the therapeutic concentration in the brain cannot be achieved, and the reaction is
inadequate. Intranasal medication delivery is one intriguing technique for avoiding first-pass metabolism
and bypassing the blood-brain barrier. It lowers medicine doses while reducing systemic
side effects. Compared to conventional drug delivery platforms, a nanoparticulate drug delivery
method allows for greater penetration via the nasal route. It is better to make the nanoparticles for
nose-to-brain administration when a good carrier (polymers) is used. This review focuses on the
many processes for creating polymeric nanoparticles, strategies and tactics for improving nose-tobrain
drug delivery efficiency, and nanoparticle characterization. The use of the nose-to-brain drug
delivery platform is being explored using a variety of nanoparticles created by researchers for the
treatment of brain illnesses.
Exosomes as Delivery Systems for Targeted Tumour Therapy: A Systematic
Review and Meta-analysis of In vitro Studies
Authors: Muhammad Suleiman Alhaji , Mohammed Jaafaru Sani , Rabiu Sulaiman 
Published: September 2022

Background:
Delivery systems with low immunogenicity and toxicity are believed to
enhance the efficacy of specific targeted drug delivery to cancer cells. Exosomes are potential
natural nanosystems that can enhance the delivery of therapeutic agents for targeted cancer therapy.

Objective:
This study provides a precise effect size of exosomes as nanovesicles for in vitro delivery
of anticancer agents.

Method:
In this systematic review and meta-analysis, the efficacy of exosomes as nanocarriers for
the delivery of therapeutic molecules was investigated using the random-effects model. We did
comprehensive literature searches through CINAHL, Cochrane, PubMed, Scopus, and Science
Direct of in vitro studies that reported exosomes as delivery systems for cancer therapy.

Results:
After the screening of eligible articles, a total of 50 studies were enrolled for the metaanalysis.
The results showed that cancer cells treated with exosome-loaded anticancer agents for at
least 6 h significantly decreased cell viability and increased cytotoxicity with the standardized
mean difference (SMD) of -1.47 (-2.18, -0.76; (p<0.0001) and -1.66 (-2.71, -0.61; p<0.002). Exosomes
effectively delivered drugs and exogenous miRNAs, siRNAs, viruses, and enzymes to cancer
cells in vitro.

Conclusion:
This meta-analysis provides evidence of exosomes as efficient nanocarriers for the
delivery of anticancer drugs.
An Internet-Based Education Program for Human Papillomavirus Vaccination Among Female College Students in Mainland China: Application of the Information-Motivation-Behavioral Skills Model in a Cluster Randomized Trial
Authors: Si Mingyu , Su Xiaoyou , Jiang Yu , Wang Wenjun , Zhang Xi , Gu Xiaofen , Ma Li , Li Jing , Zhang Shaokai , Ren Zefang , Liu Yuanli , Qiao Youlin 
Published: September 2022

Background
Patients diagnosed with cervical cancer in the last 2 decades were mainly young females. Human papillomavirus (HPV) vaccination is the most radical way to prevent HPV infection and cervical cancer. However, most female college students in mainland China have not yet been vaccinated, and their relevant knowledge is limited. Theory-based education delivered via the internet is a potentially accessible and useful way to promote HPV vaccination among this population.

Objective
This 3-month follow-up study intended to identify the feasibility and efficacy of an information-motivation-behavioral skills (IMB) model–based online intervention for promoting awareness and willingness regarding HPV vaccination among female college students.

Methods
A 7-day online HPV education program for female college students in mainland China was developed using a cluster randomized trial design. Recruitment and questionnaire surveys were performed online without face-to-face contact. SPSS 23.0 was used for statistical analysis. The chi-square test and t test were used to compare differences in qualitative and continuous variables between intervention and control groups. The generalized estimating equation was used to test the effectiveness of the intervention with a consideration of the time factor.

Results
Among 3867 participants, 102 had been vaccinated against HPV before the study (vaccination rate of 2.6%). A total of 3484 participants were followed up after the baseline survey, with no statistical difference in the loss rate between the intervention and control groups during the intervention and follow-up periods. At different follow-up time points, HPV-related knowledge, and the motivation, behavioral skills, and willingness regarding HPV vaccination were higher in the intervention group than in the control group. HPV-related knowledge was statistically different between the 2 groups, while the motivation, behavioral skills, and willingness regarding HPV vaccination only showed statistical differences right after the intervention, reaching a peak right after the intervention and then gradually reducing over time. Furthermore, there was no statistical difference in the HPV vaccination rate between the 2 groups.

Conclusions
IMB model–based online education could be a promising way to increase the HPV vaccination rate and reduce the burden of HPV infection and cervical cancer among high-risk female college students in China.

Trial Registration
Chinese Clinical Trial Registry ChiCTR1900025476; http://www.chictr.org.cn/showprojen.aspx? proj=42672

International Registered Report Identifier (IRRID)
RR2-DOI:10.1186/s12889-019-7903-x
Online Food Security Discussion Before and During the COVID-19 Pandemic in Native Hawaiian and Pacific Islander Community Groups and Organizations: Content Analysis of Facebook Posts
Authors: Nguyen Cassandra Jean , Pham Christian , Jackson Alexandra M , Ellison Nicole Lee Kamakahiolani , Sinclair Ka`imi 
Published: September 2022

BackgroundThe Native Hawaiian and Pacific Islander (NHPI) population experiences disproportionately higher rates of food insecurity, which is a risk factor for cardiometabolic diseases such as cardiovascular disease, type 2 diabetes, obesity, and hypertension, when compared to white individuals. Novel and effective approaches that address food insecurity are needed for the NHPI population, particularly in areas of the continental United States, which is a popular migration area for many NHPI families. Social media may serve as an opportune setting to reduce food insecurity and thus the risk factors for cardiometabolic diseases among NHPI people; however, it is unclear if and how food insecurity is discussed in online communities targeting NHPI individuals.ObjectiveThe objective of this study was to characterize the quantity, nature, and audience engagement of messages related to food insecurity posted online in community groups and organizations that target NHPI audiences.MethodsPublicly accessible Facebook pages and groups focused on serving NHPI community members living in the states of Washington or Oregon served as the data source. Facebook posts between March and June 2019 (before the COVID-19 pandemic) and from March to June 2020 (during the COVID-19 pandemic) that were related to food security were identified using a set of 36 related keywords. Data on the post and any user engagement (ie, comments, shares, or digital reactions) were extracted for all relevant posts. A content analytical approach was used to identify and quantify the nature of the identified posts and any related comments. The codes resulting from the content analysis were described and compared by year, page type, and engagement.ResultsOf the 1314 nonduplicated posts in the 7 relevant Facebook groups and pages, 88 were related to food security (8 in 2019 and 80 in 2020). The nature of posts was broadly classified into literature-based codes, food assistance (the most common), perspectives of food insecurity, community gratitude and support, and macrolevel contexts. Among the 88 posts, 74% (n=65) had some form of engagement, and posts reflecting community gratitude and support or culture had more engagement than others (mean 19.9, 95% CI 11.2-28.5 vs mean 6.1, 95% CI 1.7-10.4; and mean 26.8, 95% CI 12.7-40.9 vs mean 5.3, 95% CI 3.0-7.7, respectively).ConclusionsFood security–related posts in publicly accessible Facebook groups targeting NHPI individuals living in Washington and Oregon largely focused on food assistance, although cultural values of gratitude, maintaining NHPI culture, and supporting children were also reflected. Future work should capitalize on social media as a potential avenue to reach a unique cultural group in the United States experiencing inequitably high rates of food insecurity and risk of cardiometabolic diseases.
INTUITIONISTIC FUZZY I-CONVERGENT DIFFERENCE SEQUENCE SPACES DEFINED BY COMPACT OPERATOR
Authors: Kamber Esra 
Published: September 2022

In this paper, we introduce and study the intuitionistic fuzzy $I$-convergent difference sequence spaces ${I}^{(\mu,\upsilon)}(T,\Delta)$ and ${I^{0}}^{(\mu,\upsilon)}(T,\Delta)$ using by compact operator. Also we introducce a new concept, called closed ball in these spaces. By the helping of these notions, we establish a new topological space and investigate some topological properties in intuitionistic fuzzy $I$-convergent difference sequence spaces ${I}^{(\mu,\upsilon)}(T,\Delta)$ and ${I^{0}}^{(\mu,\upsilon)}(T,\Delta)$ using by compact operator.
ON ESTIMATES FOR THE GENERALIZED DUNKL TRANSFORM AND TITCHMARSH'S THEOREM IN THE SPACE $L^{p}_{\alpha,Q}(\mathbb{R}), (1<p<=2)$
Authors: Abdellatif Akhlidj , Radouan Daher , Dahani Afaf , El Hamma Mohamed 
Published: September 2022

In this paper, we study two estimates useful in applications are proved for the generalized Dunkl tranform in the space $L^{p}_{\alpha,Q}(\mathbb{R})$ where $1<p\leq2$ and $\alpha>\frac{-1}{2}$, as applied to some classes of functions characterized by a generalized modulus of continuity and we extend two interesting E.C. Titchmarsh's theorems with the higher order at same space.
ADDITIVE PROPERTIES OF THE DRAZIN INVERSE FOR MATRICES AND BLOCK REPRESENTATIONS: A SURVEY
Authors: Višnjić Jelena 
Published: September 2022

In this paper, a review of a development of the Drazin inverse for the sum of two matrices has been given. Since this topic is closely related to the problem of finding the Drazin inverse of a 2x2 block matrix, the paper also offers a survey of this subject.
CARDIOVASCULAR RISK FACTORS IN PHYSICALLY ACTIVE FEMALE UNIVERSITY STUDENTS
Authors: Purenović-Ivanović Tijana , Stojanović Stefan , Veličković Verica , Živković Danijela , Đošić Anđela 
Published: September 2022

Cardiovascular diseases are the leading cause of death in the world, and occur as a result of many risk factors (obesity, high blood pressure, inadequate physical activity, hyperlipoproteinemia, inadequate diet and an unhealthy lifestyle). Given that in young adults most of these risk factors tend to remain at the same level or to even increase with age, especially after the second or third decade of life. This means that if young adults are in the at-risk group in terms of cardiovascular diseases, they usually stay in that group in later life. The research problem is to examine the strength and significance of possible linear correlations of certain cardiovascular risk factors in 53 physically active female university students (PE students), aged 19 to 25 years, as well as to examine possible differences between those with different lengths of sports experience (ranging from 0 to 5, 6 to 10 and 11 to 15 years). Their baseline characteristics (age, body height and mass, body mass index - BMI, resting metabolic rate - RMR, resting heart rate - RHR and length of sports experience) were determined, as well as the linear relationships of selected cardiovascular risk factors (body fat percentage - BF%, visceral fat level - Visc F, waist circumference - WC, arterial blood pressure - SBP and DBP). The data were analyzed (descriptive statistics, the Kolmogorov-Smirnov test, Peаrson’s and Spearman’s correlation coefficient, ANOVA) using SPSS 21.0. The results of the analysis indicated a lack of statistically significant differences in cardiovascular risks factors between female PE students with different lengths of sports experience, and the existence of statistically significant (p<0.001), positive, mostly strong correlations, between most of the selected cardiovascular risk factors. When it comes to blood pressure parameters, although weak positive and statistically significant (p<0.05) correlations were established between SBP and BMI (r=.273), SBP and WC (r=.308), so as between DBP and body mass (r=.284), DBP and RHR (r=.287), DBP and RMR (r=.292), as well between DBP and WC (r=.304) and DBP and SBP (r=.571, p<0.001), it is unequivocal that the reduction of body mass at the expense of adipose tissue is necessary, as well as an increase in the moderate physical activity level and regularity, in order to reduce the risk of cardiovascular diseases in female PE students now as well as in older age.
IDENTIFYING WOMEN WITH PSYCHOLOGICAL PROBLEMS DURING THE IN VITRO FERTILIZATION PROCESS: THE PSYCHOLOGICAL EVALUATION TEST (PET)
Authors: Opsenica Kostić Jelena , Mitrović Milica 
Published: September 2022

Especially strong or inadequate emotional reactions during in vitro fertilization (IVF) treatment may affect both the success of the treatment and later mental health. This study tested the possibility of using Psychological Evaluation Test for Infertile Couples (PET) scores to identify women with psychological problems during the IVF process, so that they can be offered psychological counseling. The sample comprised 158 women, all of whom were undergoing the IVF treatment at the time of the study, and 128 women who had at least one child conceived without difficulties. All of the respondents filled in a questionnaire concerning their emotional status and coping competencies, while the PET was given only to the respondents undergoing IVF. Respondents with higher PET scores (> 30) have significantly higher Negative Affectivity and Shame in front of others, and lower Positive Affectivity and Coping competencies than the group with low PET scores (≤ 30) and women who conceived without difficulties. Respondents with lower PET scores do not significantly differ from women who conceived without difficulties. The results obtained suggest that the PET cut-off score > 30 may be considered a reliable measure to identify women with psychological problems i.e., reaching scores of > 30 can be taken as an indicator of the need for psychological support.
Women’s speech, a call for economic empowerment: An appraisal analysis
Authors: Adisti Aprilian Ria , Hasbi Muhammad 
Published: September 2022

The phenomenon of women participation in entrepreneurship sector is rising significantly during the last decade. In reality, women still face many barriers in entrepreneurship both professionally and personally. In 29 August 2019, Najwa Shihab delivered an inspiring keynote speech in Global Conference on Women and Entrepreneurship held by Alibaba and Lazada in Jakarta. Since Najwa Shihab's speech got many responses from the audiences, it is highly considerable to investigate the content of the speech from a linguistic point of view. This study aimed at analyzing the spoken text from Najwa Shihab’s speech through Critical Discourse Analysis (CDA). For specific investigation, Appraisal framework was used in this study. The study focused on the attitude which relates to the feelings, emotion, reactions, and judgments of behaviour on Najwa Shihab’s speech about women and entrepreneurship. The design of the study was descriptive qualitative. The findings showed that the speech used 55 clauses which consisted of 27 clauses of affect (49%), 18 clauses of judgment (33%), and 10 clauses of appreciation (18%). All clause-complexes had attitudes. The use of affect dominated the percentage of attitudes. Furthermore, this speech also encouraged women to do 3 things: dare to change the paradigm of clichés and stereotypes into strength, dare to take a role in the national and global economy to ensure that women's voices and perspectives are present in every discussion and decision making, and support each other and bring the community that can empower other women.
Diabetes and obesity in Down Syndrome across the lifespan: a retrospective cohort study using UK electronic health records
Authors: Aslam Aisha A , Baksh R Asaad , Pape Sarah E , Strydom Andre , Gulliford Martin C , CHANG Lian Fong 
Published: September 2022

<p> </p>
<p><strong>Objective</strong></p>
<p>Down Syndrome (DS) is the commonest form of chromosomal trisomy. Genetic factors in DS may increase the risk for diabetes. This study aimed to determine whether DS is associated with increased incidence of diabetes and the relationship with obesity across the lifespan compared to controls. </p>
<p><strong>Methods</strong><br>
Matched population-based cohort study (UK Clinical Practice Research Datalink, 1990-2020). </p>
<p><strong>Results</strong> <br>
9,917 DS and 38,266 control patients were analysed. Diabetes rates were higher in DS individuals (incidence rate ratio 3.67; 95% CI 2.43 – 5.55; p<0.0001) and peaked at younger age; median age at diagnosis of 38 (28 to 49) years compared to 53 (43 to 61) years in controls. Incidence rates for T1DM were 0.44 per 1,000 patient years (0.31 to 0.61) in DS compared to 0.13 (0.09 to 0.17) in controls. T2DM rates were higher in DS compared to controls at age groups 5 years up to 34 years. In DS, peak mean BMI (kg/m2) was higher and at younger age (male=31.2 at 31 years; female=32.1 at 43 years) compared to controls (males=29.5 at 54 years; females 29.2 at 51 years); obesity was associated with an increased incidence of T2DM.</p>
<p><strong>Conclusions</strong> <br>
At younger ages, the incidence of diabetes in DS patients is up to four times that of controls. Peak mean BMI is higher and established earlier in DS, contributing to T2DM risk. Further investigation into the relationship between obesity and diabetes in DS is required to inform treatment and prevention measures.</p>