bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trace-element analysis of mineral grains in Ryugu rock fragment sections by synchrotron-based confocal X-ray fluorescence
Authors: Bazi Benjamin , Tack Pieter , Lindner Miles , Vekemans Bart , De Pauw Ella , Tkalcec Beverley , Brenker Frank E. , Garrevoet Jan , Falkenberg Gerald , Yabuta Hikaru , Yurimoto Hisayoshi , Nakamura Tomoki , Amano Kana , Matsumoto Megumi , Fujioka Yuri , Enokido Yuma , Nakashima Daisuke , Uesugi Masayuki , Naraoka Hiroshi , Noguchi Takaaki , Okazaki Ryuji , Sakamoto Kanako , Yada Toru , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Yogata Kasumi , Abe Masanao , Okada Tatsuaki , Usui Tomohiro , Yoshikawa Makoto , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Nakazawa Satoru , Tachibana Shogo , Watanabe Sei-ichiro , Tsuda Yuichi , Vincze Laszlo 
Published: November 2022

AbstractA fundamental parameter-based quantification scheme for confocal XRF was applied to sub-micron synchrotron radiation X-ray fluorescence (SR-XRF) data obtained at the beamline P06 of the Deutsches Elektronen-Synchrotron (DESY, Hamburg, Germany) from two sections C0033-01 and C0033-04 that were wet cut from rock fragment C0033 collected from Cb-type asteroid (162173) Ryugu by JAXA’s Hayabusa2 mission. Trace-element quantifications show that C0033 bulk matrix is CI-like, whereas individual mineral grains (i.e., magnetite, pyrrhotite, dolomite, apatite and breunnerite) show, depending on the respective phase, minor to strong deviations. The non-destructive nature of SR-XRF coupled with a new PyMca (a Python toolkit for XRF data analysis)-based quantification approach, performed in parallel with the synchrotron experiments, proves to be an attractive tool for the initial analysis of samples from return missions, such as Hayabusa2 and OSIRIS-REx, the latter returning material from a B-type asteroid (101955) Bennu in 2023.
Graphical Abstract
Pathophysiology of fluid administration in critically ill patients
Authors: Messina Antonio , Bakker Jan , Chew Michelle , De Backer Daniel , Hamzaoui Olfa , Hernandez Glenn , Myatra Sheila Nainan , Monnet Xavier , Ostermann Marlies , Pinsky Michael , Teboul Jean-Louis , Cecconi Maurizio 
Published: November 2022

AbstractFluid administration is a cornerstone of treatment of critically ill patients. The aim of this review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms related to the interplay of flow and pressure variables, the systemic response to the shock syndrome, the effects of different types of fluids administered and the concept of preload dependency responsiveness. In this context, the relationship between preload, stroke volume (SV) and fluid administration is that the volume infused has to be large enough to increase the driving pressure for venous return, and that the resulting increase in end-diastolic volume produces an increase in SV only if both ventricles are operating on the steep part of the curve. As a consequence, fluids should be given as drugs and, accordingly, the dose and the rate of administration impact on the final outcome. Titrating fluid therapy in terms of overall volume infused but also considering the type of fluid used is a key component of fluid resuscitation. A single, reliable, and feasible physiological or biochemical parameter to define the balance between the changes in SV and oxygen delivery (i.e., coupling “macro” and “micro” circulation) is still not available, making the diagnosis of acute circulatory dysfunction primarily clinical.
High-efficiency secretory expression and characterization of the recombinant type III human-like collagen in Pichia pastoris
Authors: Xiang Zhi-Xiang , Gong Jin-Song , Shi Jin-Hao , Liu Chun-Fang , Li Heng , Su Chang , Jiang Min , Xu Zheng-Hong , Shi Jin-Song 
Published: November 2022

AbstractCollagen, the highest content protein in the body, has irreplaceable biological functions, and it is widespread concerned in food, beauty, and medicine with great market demand. The gene encoding the recombinant type III human-like collagen α1 chain fragment was integrated into P. pastoris genome after partial amino acids were substituted. Combined with promoter engineering and high-density fermentation technology, soluble secretory expression with the highest yield of 1.05 g L−1 was achieved using two-stage feeding method, and the purity could reach 96% after affinity purification. The determination of N/C-terminal protein sequence were consistent with the theoretical expectation and showed the characteristics of Gly-X-Y repeated short peptide sequence. In amino acid analysis, glycine shared 27.02% and proline 23.92%, which were in accordance with the characteristics of collagen. Ultraviolet spectrum combined with Fourier transform infrared spectroscopy as well as mass spectrometry demonstrated that the target product conformed to the characteristics of collagen spectrums and existed as homologous dimer and trimer in the broth. This work provided a sustainable and economically viable source of the recombinant type III human-like collagen.
Graphical Abstract
Effects of lighting conditions and accommodation on the three-dimensional position of Visian implantable collamer lens
Authors: Niu Lingling , Zhang Zhe , Miao Huamao , Zhao Jing , Wang Xiaoying , He Ji C. , Zhou Xingtao 
Published: November 2022

Abstract
Background
To investigate the effects of lighting conditions and accommodation on the three-dimensional position of Visian implantable collamer lens (ICL V4c).

Methods
This observational study recruited 62 eyes of 31 myopia patients underwent ICL V4c implantation. Anterior segment optical coherence tomography (AS-OCT) assessed the anterior chamber depth (ACD), ACD-ICL (distance from the corneal endothelium to anterior surface of the ICL V4c), vault (distance between the posterior ICL V4c surface and anterior crystalline lens surface), and crystalline lens tilt under various lighting conditions and accommodation relative to the corneal topographic axis at one year after ICL V4c implantation. Baseline was defined as the scotopic condition, which was also the non-accommodative stimulus condition. The ICL V4c tilt was analyzed using MATLAB. The significance level was set at P < 0.05.

Results
The ACD-ICL values were similar under various lighting conditions (P = 0.978) but decreased during accommodation (P < 0.001). The vault was significantly smaller under mesopic and photopic conditions than the baseline (P = 0.044 and P < 0.001, respectively) but remained unchanged during accommodation (P = 0.058). The inferotemporal proportion of ICL V4c (88.7%, 55 eyes) and crystalline lens (74.2%, 46 eyes) tilts were not significantly different (P = 0.063). Crystalline lens under various lighting conditions and accommodation exhibited similar tilts. The vertical tilt of ICL V4c was significantly larger under photopic conditions than the baseline (P = 0.038). The horizontal and total tilts were significantly decreased during accommodation (P = 0.043 and 0.013, respectively).

Conclusions
The axial position of ICL V4c in the anterior chamber was stable under various lighting conditions. Lighting conditions and accommodation may influence vertical, horizontal and total tilts of ICL V4c.
Bringing anchoring and embedding together: theorising migrants’ lives over-time
Authors: Grzymala-Kazlowska Aleksandra , Ryan Louise 
Published: November 2022

AbstractIn this paper, we bring together two concepts that we have been developing separately over recent years, to challenge linear and simplistic notions of migrant integration, depict multi-dimensional processes of settling and changeability over time. The concept of embedding has been proposed to capture dynamism beyond the more static notion of Granovetter’s embeddedness. The concept explores the contexts and contingencies of where and how migrants establish different degrees of attachment in different places and through different social relationships. Also the concept of anchoring has been developed to offer an antireductionist processual and multi-dimensional understanding of migrant adaptation and settling, highlighting the issues of security and stability. In this paper, using longitudinal research, we explore for the first time how bringing our two concepts together may offer additional insights and understandings of migrants’ experiences of and responses to the uncertainties and complexities of contemporary society, exacerbated by Brexit.
Assessment of inflammatory markers and their association with disease mortality in severe COVID-19 patients of tertiary care hospital in South India
Authors: Devang Nayana , Sreelatha Souparnika , B. V. Mamatha 
Published: November 2022

Abstract
Background
COVID-19 infection involves a complex interplay of the immunological and inflammatory responses. Low blood-oxygen levels have been a hallmark in COVID-19 patients. The lung tissue damage infiltered by the viral-mediated inflammation decreases oxygen saturation to cause silent hypoxia and cell death. This study aimed to evaluate the association of inflammatory biomarkers with oxygen saturation (SpO2) and mortality in severe COVID-19 patients.

Methods
A total of 190 severe COVID-19 patients were included in this study after confirmed by the RT-PCR assay. The laboratory tests were performed for biochemical assessment. Serum levels of C-reactive protein (CRP), lactate dehydrogenase (LDH), and ferritin were determined and compared between survivors and nonsurvivors using independent sample t-test. The correlation of these inflammatory markers was studied using Spearman’s correlation, and their association with mortality was studied using logistic regression.

Results
All the COVID-19 patients were severe with SpO2< 90% and respiratory rate > 30/min. While the serum levels of CRP, LDH, ferritin, aspartate transaminase (AST), urea, and random blood sugar (RBS) were elevated, hemoglobin (Hb) and SpO2 levels were reduced in COVID-19 patients. LDH and ferritin levels were significantly higher in nonsurvivors compared to survivors with p values of 0.001 and 0.022 respectively. Spearman’s correlation showed a significant correlation of the inflammatory markers with SpO2, serum electrolytes (potassium, chloride), liver enzymes (AST and alanine transaminase (ALT)), and markers of kidney damage (urea, creatinine).

Conclusion
Inflammatory markers could effectively discriminate the risk of mortality in severe COVID-19 patients. As CRP, LDH, and ferritin levels determine the tissue oxygen availability, they seem to be valuable biomarkers in the prognosis of COVID-19.
IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer
Authors: Mucci Lorelei A. , Vinson Jacob , Gold Theresa , Gerke Travis , Filipenko Julie , Green Rebecca M. , Anderson Simon G. , Badal Simone , Bjartell Anders , Chi Kim N. , Davis Ian D. , Enting Deborah , Fay André P. , Lazarus John , Mateo Joaquin , McDermott Ray , Odedina Folakemi T. , Olmos David , Omlin Aurelius , Popoola Ademola A. , Ragin Camille , Roberts Robin , Russnes Kjell M. , Waihenya Charles , Stopsack Konrad H. , Hyslop Terry , Villanti Paul , Kantoff Philip W. , George Daniel J. ,   on behalf of the IRONMAN Global Team
Published: November 2022

PURPOSE To describe a newly established international registry recruiting diverse patients with advanced prostate cancer across academic and community practices to address unmet needs in this population. PATIENTS AND METHODS Initiated in 2017, IRONMAN (International Registry for Men with Advanced Prostate Cancer) is a prospective cohort of patients with advanced prostate cancer. The study will enroll 5,000 patients with metastatic hormone-sensitive prostate cancer (mHSPC) or castration-resistant prostate cancer (CRPC), recruited from Australia, the Bahamas, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, South Africa, Spain, Sweden, Switzerland, the United Kingdom, and the United States. The study is collecting datatypes to study variation in care and treatment of advanced prostate cancer across countries and across academic, community-based, and government practices with a focus on clinical outcomes, patient-reported outcomes, epidemiologic data, biologic subtypes, and clinician questionnaires. RESULTS Through July 2022, 2,682 eligible patients were enrolled in 11 of 12 active countries. Sixty-six percent of patients have mHSPC, and 34% have CRPC. On the basis of self-report, 11% of patients are Black and 9% are Hispanic. Five Veterans Affairs Medical Centers are enrolling patients. Globally, 23% of patients report being veterans of military service. CONCLUSION To our knowledge, this is the first international cohort of people newly diagnosed with advanced prostate cancer designed to describe variations in patient management, experiences, and outcomes. IRONMAN aims to identify optimal treatment sequences to improve survival, understand patient-reported outcomes, and explore novel biomarkers to understand treatment resistance mechanisms. Insights from IRONMAN will inform and guide future clinical management of people with mHSPC and CRPC. This cohort study will provide real-world evidence to facilitate a better understanding of the survivorship of people with advanced prostate cancer.
Optimal Treatment Duration of Bevacizumab as Front-Line Therapy for Advanced Ovarian Cancer: AGO-OVAR 17 BOOST/GINECO OV118/ENGOT Ov-15 Open-Label Randomized Phase III Trial
Authors: Pfisterer Jacobus , Joly Florence , Kristensen Gunnar , Rau Joern , Mahner Sven , Pautier Patricia , El-Balat Ahmed , Kurtz Jean-Emmanuel , Canzler Ulrich , Sehouli Jalid , Heubner Martin L. , Hartkopf Andreas D. , Baumann Klaus , Hasenburg Annette , Hanker Lars C. , Belau Antje , Schmalfeldt Barbara , Denschlag Dominik , Park-Simon Tjoung-Won , Selle Frédéric , Jackisch Christian , Burges Alexander , Lück Hans-Joachim , Emons Günter , Meier Werner , Gropp-Meier Martina , Schröder Willibald , de Gregorio Nikolaus , Hilpert Felix , Harter Philipp 
Published: November 2022

PURPOSE To compare standard versus extended duration of bevacizumab treatment in combination with front-line chemotherapy in women with newly diagnosed stage IIB-IV ovarian cancer. METHODS In this multicenter, open-label, randomized phase III trial (ClinicalTrials.gov identifier: NCT01462890 ), patients with newly diagnosed International Federation of Gynecology and Obstetrics stage IIB-IV epithelial ovarian, fallopian tube, or peritoneal cancer underwent primary cytoreductive surgery followed by six cycles of chemotherapy (paclitaxel 175 mg/m2 plus carboplatin area under the curve 5 once every 3 weeks) and bevacizumab (15 mg/kg once every 3 weeks). Patients were randomly assigned 1:1 to receive bevacizumab for either 15 or 30 months, stratified by International Federation of Gynecology and Obstetrics stage/residual tumor. The primary end point was investigator-assessed progression-free survival (PFS) according to RECIST version 1.1. Secondary end points included overall survival (OS), safety, and tolerability. RESULTS Between November 11, 2011, and August 6, 2013, 927 women were randomly assigned. There was no difference in PFS between treatment arms (hazard ratio, 0.99; 95% CI, 0.85 to 1.15; unstratified log-rank P = .90). Median PFS was 24.2 versus 26.0 months with standard versus extended duration of bevacizumab, respectively; restricted mean PFS was 39.5 versus 39.3 months, respectively. There was no OS difference between treatment arms (hazard ratio, 1.04; 95% CI, 0.87 to 1.23; P = .68). Serious/nonserious adverse events of special interest occurred in 29% versus 34% of patients in the standard versus experimental arms, respectively, and were consistent with the known safety profile of standard bevacizumab. CONCLUSION Longer treatment duration with bevacizumab for up to 30 months did not improve PFS or OS in patients with primary epithelial ovarian, fallopian tube, or peritoneal cancer. A bevacizumab treatment duration of 15 months remains the standard of care.
Achieving a Cure Without Total Mesorectal Excision in Rectal Adenocarcinoma
Authors: Hall William A. , Smith J. Joshua 
Published: November 2022

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice.Rectal cancer is a curable disease, yet curing the disease can be associated with lifelong morbidity because of the nature of the curative-intent treatment strategies. A major focus of modern prospective trials has been to maintain current cure rates, while minimizing lifelong lifestyle alterations and maximizing quality of life. Navigating the complex landscape of therapeutic options for rectal adenocarcinoma with a focus to accomplish this quality-of-life improvement is a critical focus area for future clinical trials. Many challenges remain on the path to optimizing cure and minimizing morbidity, and include improving initial staging accuracy, more precise selection of neoadjuvant therapy used for each patient, choosing the optimal surgical management strategy, and ensuring modern radiation therapy approaches are being used. Finally, organ preservation strategies have moved to the forefront in the management of both early and locally advanced rectal cancers and hold the potential for significant changes to come for patients with rectal cancer. Herein, we highlight some of the challenges remaining in the field, progress made, and how the recent data from the Canadian Cancer Trials Group phase II trial can be put into context with the ACOSOG Z6041, CARTS, and GRECCAR2 trials.
Six Novel Variants in the MKRN3 Gene Causing Central Precocious Puberty
Authors: Gernay Caroline , Brachet Cécile , Boros Emese , Tenoutasse Sylvie , Libioulle Cécile , Heinrichs Claudine 
Published: November 2022

Abstract

Context
Idiopathic central precocious puberty (iCPP) is defined by the premature reactivation of the hypothalamic-pituitary-gonadal axis with normal magnetic resonance imaging scan of the central nervous system, causing the development of secondary sexual characteristics before age 8 years in girls and 9 years in boys. MKRN3 loss of function variants now represent the most common genetic cause of iCPP.

Objective
This work aims to document the clinical course of puberty in 8 families harboring pathogenic MKRN3 variants.

Methods
This is an observational case series study of patients with CPP due to MKRN3 variants followed in a single center.

Results
Genetic analysis of MKRN3 was carried out in 28 unrelated patients with iCPP and a family history of paternal inheritance or no/unavailable maternal inheritance, particularly in case of very early and rapidly evolving CPP. We identified 6 novel and 2 recently described variants in the MKRN3 gene in 9 girls, 1 boy, and their family members. These mutations were all predicted to be deleterious by in silico prediction programs

Conclusion
We have identified 6 novel MKRN3 mutations in children with CPP. An MKRN3 loss of function should be considered after careful history pinpointing paternally inherited CPP. A family segregation study allowed the detection of an MKRN3 variant in 2 young brothers still prepubertal, raising the question of screening and management of asymptomatic prepubertal family members.
What a (Young) Woman Wants: Concurrent Effects of Desire to Avoid Pregnancy and Desire for Sex on Sexual Intercourse and Contraceptive Use
Authors: Eilers Michelle A. 
Published: November 2022

Abstract
Of all pregnancies among young women in the United States, more than 60% are undesired, yet explanations for this phenomenon remain elusive. While research has investigated how pregnancy desires and intentions shape pregnancy-related behavior, only recently have scholars noted that desire for sex influences these same behaviors. Many young women simultaneously experience strong desires for sex alongside a strong desire to avoid pregnancy, but few studies have considered the extent to which young women adapt their reproductive behaviors in response to these potentially competing desires. Using novel weekly panel data, this analysis assesses how desires for sex may moderate the effect of the desire to avoid pregnancy on a young woman's sexual behavior and contraceptive use. Findings suggest that when a woman strongly wants to avoid pregnancy, she is less likely to have sex and more likely to use hormonal or coital contraceptives. As her desire for sex increases, however, she is instead more likely to have sex and use hormonal contraceptives. If she does not use hormonal methods, she is less likely to use coital contraceptives when she has intercourse. These findings highlight the importance of recognizing the desire for sex as a behavioral modifier for avoiding undesired pregnancy in the transition to adulthood.
Battle for Housing and Mutual Witnessing
Authors: Pierobon Camila 
Published: November 2022

AbstractThis article reflects on the dangers related to the circulation and displacement of the urban poor in Brazil, which intensified during the COVID-19 pandemic. The author describes a moment when Black women with small children asked for permission from the leadership of a local drug trafficking group to invade the empty rooms of the Nelson Mandela Occupation in downtown Rio de Janeiro, a common practice in the dispute for housing. However, suddenly there was a transformation in the logic of invasions. Rooms where single men lived became targets of dispute generating displacements between houses and cities. These practices are embedded in an intense and widespread network of mutual witness, placing questions of class, race, aging, and gender, as well as the power of criminal groups, in the same web of relationships. The author argues that local relations and mutual witnessing act in this continuum that is city-making in connection with uncertainty and opacity.
The Creative Politics of Legibility
Authors: Gurney Kim , Muyanga Neo , Pieterse Edgar 
Published: November 2022

AbstractThis conversation among a trio of interdisciplinary practitioners moves nimbly between a palace, a shed, and a kitchen—with a trickster spider as totem. Reflections on a new opera based in African folklore produced as a multimodal collaboration in Europe extends to the DIY-DIT principles of independent art spaces and the backyard appeal of a tiny space for big ideas, and concludes with a thought experiment for a new kind of urban incubator that might better attend to the stubbornly nested complexities of the city the contributors all call home: Cape Town, South Africa. The conceptual flies caught in their dialogic web include building new infrastructures to sustain polyvocal vocabularies, the necessary art of burning down and building up, opting for messy over linear time, and coming with your hands full to instantiate multimodal platforms of making.