bluuebunny/crossref_metadata_2025_split huggingface dataset:
VG161 activates systemic antitumor immunity in pancreatic cancer models as a novel oncolytic herpesvirus expressing multiple immunomodulatory transgenes
Authors: Shen Yinan , Song Wei , Lin Danni , Zhang Xiaozhen , Wang Meng , Li Yuwei , Yang Zifan , Guo Sida , Wang Zijun , Sheng Jianpeng , Murad Yanal , Ding Jun , Lou Yufeng , Pan Xinping , Wu Zongsong , Zhao Ronghua , Jia Weiguo , Bai Xueli , Liang Tingbo 
Published: August 2022

AbstractThe VG161 represents the first recombinant oncolytic herpes simplex virus type 1 carrying multiple synergistic antitumor immuno‐modulating factors. Here, we report its antitumor mechanisms and thus provide firm theoretical foundation for the upcoming clinical application in pancreatic cancer. Generally, the VG161‐mediated antitumor outcomes were analyzed by a collaboration of techniques, namely the single‐cell sequencing, airflow‐assisted desorption electrospray ionization‐mass spectrometry imaging (AFADSI‐MSI) and nanostring techniques. In vitro, the efficacy of VG161 together with immune checkpoint inhibitors (ICIs) has been successfully shown to grant a long‐term antitumor effect by altering tumor immunity and remodeling tumor microenvironment (TME) metabolisms. Cellular functional pathways and cell subtypes detected from patient samples before and after the treatment had undergone distinctive changes including upregulated CD8+ T and natural killer cells. More importantly, significant antitumor signals have emerged since the administration of VG161 injection. In conclusion, VG161 can systematically activate acquired and innate immunity in pancreatic models, as well as improve the tumor immune microenvironment, indicative of strong antitumor potential. The more robusting antitumor outcome for VG161 monotherapy or in combination with other therapies on pancreatic cancer is worth of being explored in further clinical trials.
A significant predictor of in‐hospital and long‐term mortality and progression in COVID‐19 patients: The end‐stage liver disease (MELD) score model
Authors: Kaya Yasemin , Gülcü Oktay , Aksakal Emrah , Kalkan Kamuran , Aydın Sidar Ş. , Kaya Ahmet , Bostan Sedat 
Published: August 2022

AbstractThe aim of this study is to investigate the relationship between the model for end‐stage liver disease (MELD) score and disease progression and mortality in COVID‐19 patients. The files of 4213 patients over the age of 18 who were hospitalized with the diagnosis of COVID‐19 between March 20, 2020 and May 1, 2021 were retrospectively scanned. Sociodemographic characteristics, chronic diseases, hemogram and biochemical parameters at the time they were diagnosed with COVID‐19 of the patients, duration of hospitalization, duration of intensive care unit (ICU), duration of intubation, in‐hospital mortality from COVID‐19 and outside‐hospital mortality for another reason (within the last 1 year) and recurrent hospitalization (within the last 1 year) were recorded. The MELD scores of the patients were calculated. Two groups were formed as MELD score < 10 and MELD score ≥ 10. The rate of ICU, in‐hospital mortality from COVID‐19 and outside‐hospital mortality from other causes, intubation rate, and recurrent hospitalization were significantly higher in the MELD ≥ 10 group. The duration of ICU, hospitalization, intubation were significantly higher in the MELD ≥ 10 group (p < 0.001). As a result of Univariate and Multivariate analysis, MELD score was found to be the independent predictors of ICU, in‐hospital mortality, intubation, and recurrent hospitalization (p < 0.001). MELD score 18.5 predicted ICU with 99% sensitivity and 100% specificity (area under curve [AUC]: 0.740, 95% confidence interval [CI]: 0.717–0.763, p < 0.001) also MELD score 18.5 predicted in‐hospital mortality with 99% sensitivity and 100% specificity (AUC: 0.797, 95% CI: 0.775–0.818, p < 0.001). The MELD score was found to be the independent predictors of in‐hospital mortality, ICU admission, and intubation in COVID‐19 patients.
Are bladder washing samples suitable for investigation of HPV infection in urinary bladder? Comparison in HPV prevalence between urine and washing samples
Authors: Nakagawa Tomomi , Shigehara Kazuyoshi , Kato Yuki , Kawaguchi Shohei , Nakata Hiroki , Nakano Taito , Izumi Kouji , Kadono Yoshifumi , Mizokami Atsushi 
Published: August 2022

AbstractAlthough urine and bladder washing samples are commonly used for the cytological evaluation of the bladder mucosa, it has been unknown whether these samples are likely suitable to investigate human papillomavirus (HPV) prevalence in the urinary bladder. The present study aimed to elucidate the appropriateness of spontaneously voided urine or bladder washing in screening HPV infection in the urinary bladder. Urine and bladder washing samples were obtained from 201 patients who underwent transurethral bladder tumor resection. After extracting DNA from both samples, HPV‐DNA was examined using a nested polymerase chain reaction with GP5+/6+ and MY09/11 primers. HPV genotyping was performed in the HPV‐positive samples. In situ hybridization (ISH) was performed to observe the HPV‐DNA localization in urothelial cells among cytological samples and paraffin‐embedded tumor tissues in HPV‐positive washing samples. HPV prevalence in urine and washing samples were 9.5% and 7.0%, respectively. High‐risk HPV prevalence in urine and washing samples was 7.5% and 4.0%, respectively. The most common HPV type was HPV 16, followed by HPV 52 and HPV 18 in both samples. HPV type distribution in both samples was not in agreement (κ = −0.431). The ISH analysis revealed that HPV‐DNA signal was observed in urothelial cells of five (55.7%) of nine detectable HPV‐positive cytological samples. Six (66.7%) of nine HPV‐positive cases had HPV‐DNA signals in tumor tissue. The use of washing samples was likely applicable for investigating HPV prevalence in the urinary bladder. HPV‐DNA detected in washing samples might be frequently derived from the urinary bladder.
Association of viral load with TRAIL, IP‐10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: A prospective, multicentre cohort study
Authors: Papan Cihan , Argentiero Alberto , Adams Ortwin , Porwoll Marian , Hakim Ummaya , Farinelli Edoardo , Testa Ilaria , Pasticci Maria B. , Mezzetti Daniele , Perruccio Katia , Simon Arne , Liese Johannes G. , Knuf Markus , Stein Michal , Yacobov Renata , Bamberger Ellen , Schneider Sven , Esposito Susanna , Tenenbaum Tobias 
Published: August 2022

AbstractBackgroundTo investigate the association of viral load (VL) with (i) tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), interferon gamma‐induced protein‐10, C‐reactive protein, and a combinatorial score (BV score), and (ii) clinical severity.Study DesignIn this prospective, multicentre cohort substudy, children with respiratory tract infection or fever without source were enrolled. VL for influenza virus, rhinovirus, respiratory syncytial virus, and adenovirus was measured from nasopharyngeal swabs. The reference standard diagnosis was established based on expert panel adjudication.ResultsOf 1140 recruited patients, 333 had a virus monodetection. VL for the aggregated data set correlated with TRAIL and IP‐10 levels, with the length of oxygen therapy, and inversely with the BV score. At a single viral level, only the influenza VL yielded a correlation with TRAIL, IP‐10 levels, and the BV score. Children with a viral reference standard diagnosis had significantly higher VL than those with bacterial infection (p = 0.0005). Low TRAIL (incidence rate ratio [IRR] 0.6, 95% confidence interval [CI] 0.39–0.91) and young age (IRR 0.62, 95% CI 0.49–0.79) were associated with a longer hospital stay, while young age (IRR 0.33, 95% CI 0.18–0.61), low TRAIL (IRR 0.25, 95% CI 0.08–0.76), and high VL (IRR 1.16, 95% CI 1.00–1.33) were predictive of longer oxygen therapy.ConclusionThese findings indicate that VL correlates with biomarkers and may serve as a complementary tool pertaining to disease severity.
Investigation of the turning speed for immersive environments using freehand‐based technique
Authors: Xiao Yi , Liu Tong , Han Yu , Yue Kang , Liu Yue 
Published: August 2022

AbstractDesigning a natural, usable, and efficient gesture‐based virtual locomotion interface in immersive environments has been challenging. Freehand‐based virtual locomotion technique (VLT) has the advantage of eliminating the need to see the handhold devices and has been implemented in many applications. Translation control and direction control are two essential components of freehand‐based VLT; however, the transfer function of turning speed in direction control has not been well explored. In this article, we systematically investigate the effects of turning speed on freehand‐based virtual locomotion for the first time. A transfer function that maps the position of the hand to the turning speed is defined, and three parameters related to the turning speed are investigated. In the experiment, participants are asked to travel in the virtual environment from a first‐person perspective with different parameters. Statistical analysis of the experimental results reveals the relationship between the turning speed and the traveling performance as well as the traveling experience.
Survival Outcomes of Patients with Mycosis Fungoides Involving the External Ear and Ear Canal
Authors: Wilkinson Alex J. , Nader Marc‐Elie , Roberts Dianna , Duvic Madeleine , Gunther Jillian R. , Dabaja Bouthaina S. , Gidley Paul W. 
Published: August 2022

Objectives/HypothesisMycosis Fungoides (MF) is the most common subtype of cutaneous T‐cell lymphoma. Disease involvement of specific locations may be more significant than simply the symptoms associated with that site; it is possible that involvement of certain sites could be associated with poor prognosis. We aimed to evaluate the outcomes of patients with MF with documented involvement of the EAC and external ear.Study DesignRetrospective analysis.MethodsWe retrospectively reviewed 40 patients with MF that were treated by otologists between 2012 and 2021.ResultsWe report the largest series of patients with MF involving the external ear and EAC. Of the 40 patients included in this study, 17 presented with Mycosis Fungoides in the otologic region (MFO). Of these 17 MFO patients, 2/17 had involvement of the external ear only, 3/17 of the EAC only, 11/17 of both the external ear and EAC, and 1/17 of the periauricular skin. Of note, 11/14 (79%) patients presenting with EAC disease died compared to11/26 (42%) of patients without involvement. In addition, eight of the 13 (62%) patients with external ear involvement died compared to 14/27 (52%) of patients without involvement. Ear canal involvement was associated with a statistically significant shorter overall survival duration in patients with MF (p = 0.03). Furthermore, disease in the EAC was found to have a hazard ratio value of 2.565 (CI 1.102–5.970).ConclusionsInvolvement of the EAC by MF portends a poor prognosis. This finding highlights the need for a more in‐depth otologic evaluation of patients with MF.Level of Evidence4 Laryngoscope, 133:1486–1491, 2023
Effect of Opicapone on Levodopa Pharmacokinetics in Patients with Fluctuating Parkinson's Disease
Authors: Ferreira Joaquim J. , Poewe Werner , Rascol Olivier , Stocchi Fabrizio , Antonini Angelo , Moreira Joana , Guimarães Bruno , Rocha José‐Francisco , Soares‐da‐Silva Patrício 
Published: August 2022

ABSTRACTBackgroundInhibiting catechol‐O‐methyltransferase extends the plasma half‐life of levodopa, potentially allowing physicians to optimize the levodopa regimen in patients with Parkinson's disease (PD) experiencing motor fluctuations.ObjectivesTo evaluate the effects of once‐daily opicapone on levodopa plasma pharmacokinetics and motor response when added to two different levodopa dosing regimens.MethodsA total of 24 patients with PD and motor fluctuations were enrolled in an exploratory, open‐label, modified cross‐over trial. Participants first received levodopa/carbidopa 500/125 mg (five intakes) for 2 weeks and were then randomly assigned (1:1) to levodopa/carbidopa 400/100 mg given over either four or five daily intakes plus opicapone 50 mg for an additional 2 weeks. Levodopa 12‐hour pharmacokinetics was the primary outcome (ie, excluding the effect of last/evening levodopa/carbidopa intake), with motor complications evaluated as secondary outcomes.ResultsOver 12‐hour pharmacokinetics and compared with five‐intake levodopa/carbidopa 500/125 mg without opicapone, maximal levodopa concentrations were similar or nonsignificantly higher on both levodopa/carbidopa 400/100 mg regimens plus opicapone. Despite a 100 mg lower total levodopa/carbidopa daily dose, adding opicapone 50 mg at least doubled the levodopa plasma half‐life and minimal concentrations, with a significant ≈30% increase in total exposure. The levodopa fluctuation index was only significantly lower for the five intakes plus opicapone regimen (difference of −71.8%; P < 0.0001). Modifications to levodopa pharmacokinetics were associated with decreased off time and increased on time.ConclusionsCombining opicapone 50 mg with a 100 mg lower daily dose of levodopa provides higher levodopa bioavailability with avoidance of trough levels. Despite the lower levodopa dose, modifying the levodopa pharmacokinetic profile with opicapone was associated with decreased off time and increased on time. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Trendbericht Lebensmittelchemie 2022
Authors: Oellig Claudia 
Published: August 2022

AbstractAnalyten in Lebensmitteln müssen in immer kürzerer Zeit bestimmt werden. Daher gewinnen schnelle und einfache Screening‐Methoden an Bedeutung. Dies gilt insbesondere für die Analytik von Rückständen und Kontaminanten, welche die Lebensmittelsicherheit beeinträchtigen können.
Halide perovskite materials as chemical playground
Authors: Hutter Eline M. 
Published: August 2022

AbstractDue to their excellent optoelectronic performance, and relatively easy processibility, halide perovskite semiconductors are used in highly efficient solar cells, LEDs, X‐ray detectors, and more recently in photo(electro)chemistry. Eline M. Hutter aims to obtain stable, non‐toxic perovskites for photoconversion applications.
Holy smoke – high life?
Authors: Pospech Jola 
Published: August 2022

AbstractCannabidiol (CBD) and tetrahydrocannabinol (THC) are literally on everyone‘s lips. The structures of these two substances are closely related but differ in their effect. Over the past years, research in the field of artificial synthesis and derivatization of cannabinoids has been flourishing. However, the term synthetic cannabinoids all too often conceals psychoactive designer drugs that bind to cannabinoid receptors and induce an (il)legal high.
Interview mit Chemiehistoriker Rudolf Werner Soukup
Authors: Schneider Walter 
Published: August 2022

AbstractDie GÖCH hat den Chemiehistoriker Rudolf Werner Soukup zu den Anfängen der GÖCH und zur Bedeutung der Publikationen befragt. Das Interview wurde im Juni 2022 in der Geschäftsstelle der GÖCH vom Geschäftsführer Walter Schneider geführt und von Petra Singer transkribiert.
Perceived Stress in Patients with Inflammatory and Non-Inflammatory Skin Conditions. An Observational Controlled Study Among 255 Norwegian Dermatological Outpatients
Authors: Balieva Flora , Schut Christina , Kupfer Jörg , Lien Lars , Misery Laurent , Sampogna Francesca , von Euler Love , Dalgard Florence J. 
Published: August 2022

Abstract

Background
Inflammation may increase stress, while stress may promote inflammation. Most dermatological conditions are chronic and inflammatory, while some, such as cancer, naevi and tumours are non-inflammatory, but may cause stress because of the fear of malignancy and the necessity for surgical and other invasive treatments. Stress among patients with skin diseases is little explored.

Objectives
To assess perceived stress in patients with inflammatory and non-inflammatory skin conditions compared to healthy controls.

Methods
Observational cross-sectional study. Consecutive outpatients (N = 255) visiting the Department of Dermatology, Stavanger University Hospital, Norway and 148 skin-healthy controls contributed by answering questionnaires on sociodemographics, stressful life events, economic difficulties, self-rated health and perceived stress. The validated Perceived Stress Scale10 was used to evaluate stress. A dermatologist examined patients and registered their diagnoses and comorbidities. Controls included in this study were not examined by a dermatologist and self-reported their comorbidities.

Results
Patients with an inflammatory skin disease or psoriasis have a tripled risk of reporting moderate to high stress compared with controls when adjusted for relevant confounders, including having experienced a stressful life event recently or having a comorbidity. Patients with a purely non-inflammatory skin disease perceived stress no differently than controls.

Conclusion
Patients with inflammatory skin disease perceived higher stress than controls and patients with non-inflammatory skin conditions. Dermatologists may play a role in awareness of the importance of stress in skin disease.
An improved model and field calibration technique for measuring liquid water content in unfrozen and frozen soils with dielectric probes
Authors: Amankwah Seth K. , Ireson Andrew M. , Brannen Rosa 
Published: August 2022

AbstractDielectric soil moisture probes can be used to obtain frequently logged field observations of volumetric water content, but because this is an indirect method, it is challenging to ensure that you have a suitable calibration relationship and parameters. Challenges are associated with (a) limitations in the probes’ ability to accurately measure the soil bulk dielectric constant and (b) limitations in obtaining reliable direct observations to calibrate the probe against, due to the spatial heterogeneity in the field. Furthermore, in soils that freeze, we do not have a robust approach to account for the effect of ice on the instrument. In this study, we propose a calibration relationship for all dielectric probes that is physically based, parsimonious, accounts for errors in the bulk dielectric constant, and quantifies the uncertainty in the liquid water content caused by the presence of ice. We show that our relationship has a better performance and more realistic parameter values than existing approaches. To calibrate a dielectric probe in the field, we show that it is necessary to account for spatial heterogeneity in samples taken for calibration. There is value in taking simultaneous measurements of the bulk dielectric constant (using the same dielectric probe as is being calibrated) and gravimetric samples for water content at a number of points in space. Taking too few samples is likely to be misinformative—we show that it is better to not calibrate the probe at all than to calibrate it with too few data points.
Habits and Lifestyle
Authors: Garrido-Cumbrera Marco , Navarro-Compán Victoria , Bundy Christine , Mahapatra Raj , Makri Souzi ,   Universidad de Sevilla, Plazuelo-Ramos Pedro , Poddubnyy Denis 
Published: August 2022

AbstractVarious aspects of the habits and lifestyle of patients with axSpA can affect their physical health, mental health, and indeed response to therapy.
Employment Status and Productivity
Authors: Garrido-Cumbrera Marco , Navarro-Compán Victoria , Bundy Christine , Mahapatra Raj , Makri Souzi ,   Universidad de Sevilla, Plazuelo-Ramos Pedro , Poddubnyy Denis 
Published: August 2022

AbstractDue to the pain, fatigue, and loss of mobility associated with their disease, patients with axSpA often struggle to meet the demands of employment, which can lead to higher rates of unemployment, sick leave (absenteeism), and impairment while at work (presenteeism) compared with the general population (Boonen et al. Ann Rheum Dis 69:1123–1128, 2010;Boonen et al. Ann Rheum Dis 60:1033–1039, 2001;; Mau et al. J Rheumatol 32:721–728, 2005; Healey et al. Scand J Rheum 40:34–40, 2011).
Diagnosis
Authors: Garrido-Cumbrera Marco , Navarro-Compán Victoria , Bundy Christine , Mahapatra Raj , Makri Souzi ,   Universidad de Sevilla, Plazuelo-Ramos Pedro , Poddubnyy Denis 
Published: August 2022

AbstractThe diagnosis of axSpA is challenging and is usually based on a combination of clinical symptoms (e.g. unexplained inflammatory back pain), patient characteristics (e.g. age <45 years, family history of axSpA, presence of genetic risk factors [human leukocyte antigen allele B27 (HLA-B27) positivity]), and the presence of inflammation on imaging (e.g. sacroiliitis on magnetic resonance imaging [MRI] or X-ray).
Introduction: ASEAN’s Strategic Utility Redefined
Authors: Koga Kei 
Published: August 2022

AbstractDoes ASEAN play a role in managing security issues in Southeast Asia and beyond? This chapter introduces the book’s core argument that, since the 1990s, ASEAN and ASEAN-led institutions have individually devised and/or shifted their own institutional strategy to manage the great-power politics pertaining to the South China Sea disputes, and that each institutional strategy aims to constrain great powers’ behavior and avoid being entrapped by their strategic competition so as to ensure member states’ interests. Strategy creation or shifts generally occur when member states perceive a change in the strategic environment relating to the South China Sea. But when ASEAN faces difficulty changing its strategy, it establishes a new institution to expand its strategic tools, which assumes a different functionality, geopolitical scope, and raison d'être. In doing so, ASEAN nurtures a quasi-division of labor among its institutions to manage the great-power politics in the South China Sea.
The Concept of Institutional Strategy and Change
Authors: Koga Kei 
Published: August 2022

AbstractThis chapter conceptualizes the types of institutional strategy and constructs a theoretical model based on agent-centered historical institutionalism to understand the timing of its strategy shifts. This theoretical model analyzes how the member states of a regional security institution perceive and assess their immediate security environment and create or change the institutional strategy. Since member states’ perception is generally affected by the regional distribution of power, the chapter emphasizes the importance of analyzing the regional strategic environment as well as agent’s decisions. The methodology of the analyses is briefly discussed through case studies on the role of ASEAN and ASEAN-led institutions regarding the SCS issue. The chapter also provides an overview and assessment of the general trend of the strategic environment in the SCS from 1990 to 2020 over four phases: 1990–2002, 2003–2012, 2013–2016, and 2017–2020. These four phases will be used as a principal indicator to understand the change and continuity of institutional strategies employed by ASEAN and ASEAN-led institutions.
Positive life events and social support and the relationship between life stress and psychological disorder
Authors: Cohen Lawrence H. , McGowan Jack , Fooskas Stephanie , Rose Sandra 
Published: August 2022

ConclusionIn conclusion, the present research demonstrated the deleterious effects of negative life events. Number of negative events was a significant predictor of psychological disorder even when initial disorder was statistically controlled. The cross‐sectional regression findings provided some support for the stress‐buffering effects of positive life events, but these effects were nonsignificant when initial disorder was statistically controlled. The cross‐sectional and prospective regression findings suggest that received social support, as measured by the ISSB, does not have a direct or stress‐buffering effect on psychological disorder. These analyses, however, demonstrated the direct and stress‐buffering effects of perceived social support, as measured by the ISEL, and the data suggest that the ISEL is a promising measure of this construct.