bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical properties and strength evolution model of sandstone considering the coupling impact of freeze and thaw weathering process and confining pressure
Authors: Xiong Xin , Zhou Keping , Gao Feng , Yang Chun , Li Jielin 
Published: March 2022

Abstract
Freeze and thaw (F&T) weathering cycles induced by day-night and seasonal temperature changes cause a large number of rock mass engineering disasters in cold areas. Investigating the impact of F&T weathering process on strength and deformation characteristics of frozen-thawed rocks is therefore of critical scientific importance for evaluating the stability and optimizing the design of rock mass engineering in these areas. In this research, the evolution characteristics of F&T damage were analysed based on T2 spectrum distribution curves of sandstone specimens before and after F&T weathering cycles. The coupling impact of the quantity of F&T weathering cycles and confining pressure on pre-peak and post-peak deformation behaviours of sandstone specimens were analysed in detail. By introducing the confining pressure increase factor (CPIF), the impact of confining pressure on triaxial compressive strength (TCS) of sandstone specimens after undergoing different quantities of F&T weathering cycles was further investigated. A novel strength evolution model was proposed that could effectively describe the coupling impact of the quantity of F&T weathering cycles and confining pressure on TCS of rocks after undergoing F&T weathering process. The proposed strength evolution model was cross-verified with experimental data from the published literature, and all correlation coefficients are above 0.95, which proves that the strength evolution model proposed in this paper is reasonable; in addition, this model has strong applicability.
Novel Object Recognition in Octopus maya.
Authors: Ovalle Fabian Vergara , Guerrero Fructouso Ayala , Rosas Carlos , Sanchez-Castillo Hugo 
Published: March 2022

Abstract

The Novel Object Recognition task (NOR) is widely used for the study of memory in vertebrates and has been proposed as a solid candidate for evaluating memory in different taxonomic groups, allowing similar and comparable evaluations between them. Although, in cephalopods, several research reports could indicate that they recognize objects in their environment, so far, it has not been evaluated as an experimental paradigm, which allows evaluating different phases of memory. In this study, we show that Octopus maya can differentiate between a new object and a known one, with high accuracy. We observed that to achieve object recognition, octopuses use vision and touch exploration in new objects, while familiar objects only need to be explored in a tactile way. To our knowledge, this is the first time showing an invertebrate performing the NOR task, in a similar way to how it is performed in vertebrates. These results raise the opportunity to use a simple, fast and widely used task in other taxonomic groups, to assess memory in octopuses.
The Provision of Complementary, Alternative, and Integrative Medicine Information and Services: A Review of World Leading Oncology Hospital Websites
Authors: De Melo Melanie N. , Pai Poojitha , Lam Michelle O. Y. , Maduranayagam Sharleen G. , Ahluwalia Kundan , Rashad Menat Alla , Popal Sahar , Gunabalasingam Janany , Muralitharan Maiura , Pradhan Anushka , Ng Jeremy Y. 
Published: March 2022

Abstract
Background
Many cancer patients use complementary, alternative, and integrative medicine (CAIM) to improve their psychological and functional health. However, there is little known about the extent of CAIM information and services provided on oncology hospital websites.
Methods
This study reviewed public-facing websites to determine the degree of CAIM information provided and services offered by the world’s leading cancer hospitals in 2021. Nine authors extracted data from hospital websites individually and in triplicate, prior to meeting to revise data extractions. Data analysis was then performed by two authors to determine how many hospitals provided CAIM descriptions and offered CAIM services, and the extent of CAIM information provided.
Results
A total of 131 hospitals were included in this study. Of the eligible hospitals, 50.38% (n = 66) provided a theoretical description of CAIM; 48.09% (n = 63) provided a description of one or more CAIM therapies; 63.36% (n = 83) offered one or more CAIM therapies to cancer patients. The most common therapies described were the same as the most common therapies offered. These therapies are massage, special foods and diets, acupuncture, meditation, yoga, and creative outlets. While CAIM therapies were commonly offered, information surrounding the benefits and side effects associated with these therapies varied.
Conclusions
Due to the lack of CAIM standardization worldwide, there is a need for increased CAIM information provision on hospital websites to better inform and empower patients to make well-informed decisions about their health.
Entrainment of Chaotic Oscillations in a Colonial Tunicate.
Authors: Konrad Michael W. 
Published: March 2022

Abstract
BackgroundTunicates comprise an invertebrate, chordate subphylum which has been shown to be the closest group to vertebrates. Colonial tunicates are clusters of genetic clones generated asexually from a single free swimming larval “tadpole”. Each individual, or zooid, of the colony has a peristaltic heart which circulates blood through that individual. In addition, each zooid is connected to a common, external vascular network. This vascular network has radial extensions that end at the colony periphery in bulbs, or ampullae, which contract and expand to generate reciprocating flow between ampullae and zooids. Surgically detached ampullae continue to beat.ResultsQuantitative scans of videos of individual ampullae in a young Botrylloides viocella colony demonstrate ampullae contractions are often in phase, with occasional abrupt phase shifts out of and back to synchrony. The vessels connecting the ampullae to the zooid also contract, mostly in phase with the ampullae. Total volumes pumped by this colonial system are a significant fraction of the zooid volume, since it contracts 180 degrees out of phase and at the same frequency as the ampullae. Reversals of the peristaltic heart are at least partially synchronized with ampullae contractions. Ampullae that have been surgically detached from the colony contract at a more uniform rate with more symmetrical profiles than when part of the colony. ConclusionContractions of the ampullae and associated vessels pump sufficient blood in and out of the zooid that they should be considered functional hearts, and the partial synchrony of ampullae contractions results in a larger blood flow compared to an alternative asynchronous contraction pattern. The manner in which the ampullae abruptly fall out of and back to synchrony indicates synchrony is due to entrainment while the out of phase contractions of the zooid may be a direct result of pumping. The shape of contraction curves of detached ampullae pairs is almost indistinguishable from a pure sine wave, indicating that the more complex original pattern was due to interactions between out of phase ampullae. Ampullae and associated vessels might be analogous with the system of lymphatic vessels in vertebrates.
Reviewing textile wastewater produced by industries: characteristics, environmental impacts, and treatment strategies
Authors: Wang Xiaoxuan , Jiang Jinming , Gao Weijun 
Published: March 2022

Abstract
The textile industry is one of the most intensive industries in chemical products whose wastewater contains hazardous dyes, pigments, dissolved/suspended solids, and heavy metals. Hence, it is important to effectively treat the wastewater generated by this industry before releasing it into the environment. Although the field of textile wastewater treatment has made tremendous progress, the developed treatment methods should be improved further to make them economically viable and friendly. In this review, characteristics of textile wastewater are introduced. We have primarily focused on the environmental impact and toxicity of textile wastewater. Toxic and harmful contaminants must be removed from textile wastewater to reduce the extent of environmental pollution caused when textile wastewater is released into rivers or reused. Hence, various techniques that are used to treat textile wastewater are discussed. Finally, the challenges faced, and prospects of the methods have been discussed in detail.
Identification and Verification of Potential Core Genes in Pediatric Septic
Shock
Authors: Jiang Meixiu , Xu Zhihao , Jiang Meiling , Bai Xiwen , Ding Lianlei , Dong Pengzhi 
Published: March 2022

Background:
Septic shock is a frequent and costly problem among patients in the pediatric
intensive care unit (PICU) and is associated with high mortality and devastating survivor
morbidity. In this study, we aimed to screen candidate biomarkers and potential therapeutic targets
for septic shock.

Methods:
GSE26440 dataset was downloaded from Gene Expression Omnibus (GEO), including
32 normal controls and 98 children with septic shock RNA samples from whole blood. The pathways
and functional annotations of differentially expressed genes (DEGs) in the two types of samples
were examined by GO and KEGG pathway enrichment analyses using the Database for Annotation,
Visualization, and Integrated Discovery (DAVID) tool. Protein-protein interactions (PPI) of
the above-described DEGs were investigated using the Search Tool for the Retrieval of Interacting
Genes (STRING) and Hub gene identification was performed by the plug-in cytoHubba in Cytoscape
software.

Results:
A total of 140 genes were identified as DEGs, of which 98 genes were up-regulated and
42 genes were down-regulated. GO function analysis showed that DEGs were significantly enriched
in biological processes, including immune response, leukocyte activation involved in immune
response, and so on. The top hub genes, namely MMP9, CEACAM8, ARG1, MCEMP1,
LCN2, RETN, S100A12, GPR97, and TRAT1 were recognized from the protein-protein interaction
(PPI) network. Furthermore, qRT-PCR results demonstrated that the mRNA level of MMP9,
CEACAM8, ARG1, MCEMP1, LCN2, RETN, and S100A12 was elevated while GPR97 was decreased
in involved mouse and human models. However, TRAT1 expression is species-dependent
which was decreased in the mouse septic shock model but elevated in the human LPS-treated macrophages
model.

Conclusion:
Taken together, the identification and validation of several novel hub genes, especially
GPR97 and TRAT1, deepen our comprehension of the molecular mechanisms of septic shock
progression. These genes may be therapeutic molecular targets or diagnostic biomarkers in patients
with septic shock.
Targeting Estrogen Signaling in the Radiation-induced Neurodegeneration:
A Possible Role of Phytoestrogens
Authors: Mitra Sarmistha , Dash Raju , Sohel Md. , Chowdhury Apusi , Munni Yeasmin Akter , Ali Md. Chayan , Hannan Md. Abdul , Islam Md. Tofazzal , Moon Il Soo 
Published: March 2022

Abstract:
Radiation for medical use is a well-established therapeutic method with an excellent prognosis rate for various cancer treatments. Unfortunately, a high dose of radiation therapy comes with its own share of side effects, causing radiation-induced non-specific cellular toxicity; consequently, a large percentage of treated patients suffer from chronic effects during the treatment and even after the post-treatment. Accumulating data evidenced that radiation exposure to the brain can alter the diverse cognitive-related signalings and cause progressive neurodegeneration in patients because of elevated oxidative stress, neuroinflammation, and loss of neurogenesis. Epidemiological studies suggested the beneficial effect of hormonal therapy using estrogen in slowing down the progression of various neuropathologies. Despite its primary function as a sex hormone, estrogen is also renowned for its neuroprotective activity and could manage radiation-induced side-effects as it regulates many hallmarks of neurodegenerations. Thus, treatment with estrogen and estrogen-like molecules or modulators, including phytoestrogens, might be a potential approach capable of neuroprotection in radiation-induced brain degeneration. This review summarized the molecular mechanisms of radiation effects and estrogen signaling in the manifestation of neurodegeneration and highlighted the current evidence on the phytoestrogen mediated protective effect against radiation-induced brain injury. This existing knowledge points towards a new area to expand to identify the possible alternative therapy that can be taken with radiation therapy as adjuvants to improve patients' quality of life with compromised cognitive function.
Differential Response to Three Antidepressants in Patients with Major
Depressive Episode Who Suffered Covid-19-Related Trauma
Authors: Lombardozzi Ginevra , Kotzalidis Georgios D. , De Filippis Sergio , Matrone Marta , Amici Emanuela , Trovini Giada , Perrini Filippo , Di Giovanni Alessandro , Giovanetti Valeria 
Published: March 2022

Background:
The Covid 19 pandemic might have impacted response to drug treatment in major depressive episode (MDE). We compared responses to three different antidepressant drugs, i.e., vortioxetine, sertraline, and trazodone, in outpatients with MDE during Major Depressive Disorder (MDD), Bipolar Disorder (BD), or schizophrenia and related psychoses (SSOPDs) during two time periods, i.e., prior to suffering Covid-19–related trauma and after suffering such trauma.

Methods:
We conducted an observational study on clinically stabilised for at least 6 months outpatients with MDE during the course of MDD (N=58), BD (N=33), or SSOPDs (N=51). Patients, whose baseline assessments of Montgomery-Åsberg Rating Scale (MADRS), Hamilton Anxiety Rating Scale (Ham-A), Brief Psychiatric Rating Scale (BPRS), Visual Analogue Scale for Craving (VAS-crav) and World Health Organization Quality of Life, Brief version (WHOQOL-BREF) were available, were recruited at the time they suffered Covid-19–related traumas. Fifty patients, prior to the pandemic, when they were clinically stable, were treated with 15 mg/die vortioxetine, 44 with 450 mg/die trazodone, and 48 with 150 mg/die sertraline. After experiencing a major Covid-19–related personal trauma, patients showed clinical worsening which required dosage adjustment (20 mg/day vortioxetine; 600 mg/day trazodone, and 200 mg/day sertraline) and, for a part of them, a month of hospitalisation. Scores on the MADRS, Ham-A, BPRS, VAS-crav and WHOQOL-BREF were compared drug-wise and gender-wise with Student’s t test for continuous variables and χ2 for categorical variables.

Result:
The sample consisted of 142 outpatients (age, mean 39.63 ± 16.84; 70 men and 72 women); women were older than men (mean age 43.18 ± 17.61 vs. 35.98 ± 15.30; p=0.01). The two genders did not differ on other variables). For all treatments, symptoms worsening was observed at the time of trauma, followed by slow recovery with treatment readjustment. Trauma-related worsening in patients on vortioxetine was less intense than patients on the other two antidepressants and recovery was faster. All drugs were associated with an improvement in QoL. The vortioxetine group showed a lower hospitalisation rate (24%) than sertraline (35.4%) and trazodone (38.6%), but this was not significant (p=0.27).

Conclusion:
All drugs improved symptoms after Covid-19 trauma in patients with MDE, with vortioxetine showing a small advantage. No differences between vortioxetine, sertraline and trazodone were found as concerns the need for hospitalisation.
Bioactive Compounds Identification, Antioxidant and Antibacterial
Activities of Algerian Marine Algae Extracts
Authors: Saidani Karima , González-Peña Diana , Giménez Lucía , Touati Naima , Bedjou Fatiha , de Ancos Begoña , Sánchez-Moreno Concepción 
Published: March 2022

Background:
Marine algae produce bioactive compounds, including polyphenols. They
have antioxidant, antibacterial, immune regulation and other biological activities. The aim of this
study was to examine the antibacterial and antioxidant activities of extracts of five marine algae
species: Cystoseira humilis, Halopteris scoparia, Pavonica padina, Sargassum vulgare and Rhodomela
confervoides of Bejaia’s coast (northern Algeria).

Methods:
Phenolic content of the five marine algae was assessed using Folin Ciocalteu method
and then characterized by HPLC-DAD and HPLC-ESI-QTOF-MS analyses. The antioxidant activity
was evaluated by DPPH•, ABTS•+, NO• radical scavenging and FRAP assays. For the screening
of the antibacterial activity, six strains were tested using three different methods: agar disc diffusion,
agar well diffusion and spot methods. The minimum inhibitory concentrations (MICs) were
also determined.

Results:
Protocatechuic acid was the phenolic compound identified in all the studied seaweeds,
while Padina pavonica was the species where more phenolic compounds were identified
(phloroglucinol, gallic acid, ferulic acid and syringic acid). Cystoseira humilis showed the highest
antioxidant activity (DPPH•: 2237.50 ± 148.34 μM TE/100 g dw, ABTS•+: 1992.50 ± 165.97 μM
TE/100 g dw, NO•: 2559.58 ± 42.08 μM TE/100 g dw, FRAP: 2081.20 ± 115.29 μM TE/100 g
dw), which was also the richest in phenolic compounds (4.63 ± 0.23 mg PhlE/g dw). Rodomela
confervoides showed an important activity against all the bacterial strains tested with the greatest
diameter of inhibition zone (18 mm) against E. coli with a MIC equal to 20 mg/mL. The extract of
Padina pavonica showed a moderate activity (13.5 mm) against P. aeruginosa with a MIC ≤ 10
mg/mL and a MBC > 10 mg/mL.

Conclusion:
The studied marine algae showed antioxidant and antibacterial activities. They could
be potentially used for applications in medicine, food production and the cosmetic industry.
Pelatihan aplikasi model peminatan untuk meningkatkan pemahaman layanan peminatan bagi Guru Bimbingan dan Konseling SMA di Kabupaten Kulonprogo
Authors: Sari Widya Juwita , Triyanto Agus , Dewanti Septinda Rima , Warsito Ariyadi , Hasna Salma Salsabila , Kartika Fenny 
Published: March 2022

Tujuan penelitian ini adalah untuk meningkatkan pemahaman Guru Bimbingan dan Konseling dalam melaksanakan peminatan siswa SMA. Khalayak sasaran dari kegiatan ini adalah Guru Bimbingan dan Konseling SMA dengan jumlah 23 Guru Bimbingan dan Konseling. Penelitian ini menggunakan metode penelitian deskriptif. Kegiatan pelatihan ini menggunakan teknik penugasan mandiri yang diawali dengan seminar dan diskusi tentang peminatan, penyusunan rencana layanan peminatan, praktik memberikan layanan peminatan dan diakhiri dengan case conference hasil peminatan berdasarkan model peminatan Siswa SMA. Alat ukur yang digunakan untuk mengetahui keefektifan teknik tersebut adalah dengan skala penilaian pelatihan peminatan Siswa SMA yang digunakan pretes dan post test. Hasil pelaksanaan kegiatan pelatihan peminatan Siswa SMA bagi Guru BK SMA menunjukkan peningkatan yang dilihat dari rata-rata skor pre-test sebesar 17,48 dan skor rata-rata post test sebesar 27,00 Dengan demikian terdapat peningkatan 9,53 poin. Berdasarkan hal tersebut dapat dikatakan pelatihan aplikasi model peminatan dapat meningkatkan pemahaman mengenai layanan peminatan Siswa SMA.
Determination of Iron (Fe) Species in Samples of Canned Packaging Beef
Authors: Haryanti Septi Dwi , Dzawinnuha Hannuna , Adika Vanadia 
Published: March 2022

The research aims to know the content of iron metal (Fe) in samples of canned packaging beef. The destruction of the samples prior to breaking the metallic bond with organic compounds in the sample, making them easier to identify the metal content to be analyzed. The analysis of metal content of iron has been done by using Atomic Absorption Specthrophotometer. The level of iron metal contained in beef samples of A brand packaging is 40.0570 mg/kg, in B brand packaging is 25.5175 mg / Kg and in the C brand packaging 22.9600 mg/Kg. When compared to the iron metal threshold in food as contained in SNI 01-7387-2009, then the sample of beef packaging for B and C brand is still safe because the iron content is still below 30 mg/kg. Meanwhile, the beef corned for A brand is not safe because it is higher than 30 mg/kg.
Eksplorasi, Seleksi dan Identifikasi Kandidat Bakteri Selulolitik Asal Ekosistem Mangrove Sungailiat, Pulau Bangka
Authors: Janatul Khulud Liza , Febrianti Dwi , Prasetiyono Eva , Robin Robin , Kurniawan Ardiansyah 
Published: March 2022

Mangrove memiliki potensi sebagai sumber bakteri pendegradasi selulosa. Pulau Bangka, yang kaya mineral timah, belum dikaji potensi bakteri selulolitiknya. Tujuan penelitian ini untuk mendapatkan kandidat bakteri selulolitik melalui seleksi isolat dari serasah daun lapuk, kayu lapuk, dan lumpur mangrove, serta mengevaluasi patogenisitas kandidat bakteri selulolitik melalui uji patogenisitas secara in vivo. Penelitian terlaksana pada bulan Januari sampai dengan April 2018. Materi uji yang digunakan pada penelitian ini adalah kandidat bakteri selulolitik yang diisolasi dari lumpur, serasah daun dan kayu lapuk dari tumbuhan mangrove dan ikan nila (Oreochromis niloticus). Metode penelitian yang digunakan yaitu metode deskriptif dan eksperimental. Metode deskriptif digunakan pada pengujian bakteri secara in vitro, pegamatan gejala klinis ikan dan kondisi organ dalam ikan setelah diberi perlakuan. Metode eksperimental digunakan pada uji patogenisitas untuk pengamatan parameter kelangsungan hidup. Perlakuan yang diberikan pada ikan uji meliputi injeksi dengan kandidat bakteri selulolitik, injeksi dengan NaCl dan tanpa injeksi. Hasil penelitian menunjukkan bahwa isolasi dan seleksi kandidat bakteri selulolitik didapatkan sebanyak empat belas isolat. Isolat kandidat bakteri selulolitik yang memiliki aktivitas selulolitik terbaik yaitu isolat bakteri yang berasal dari serasah daun mangrove dengan kode isolat SLS5. Berdasarkan uji biokimia, isolat bakteri SLS5 tersebut teridentifikasi sebagai Bacillus sp. Pengujian patogenisitas bakteri SLS5 membuktikan bahwa bakteri ini bersifat non-patogen (tidak menyebabkan sakit dan kematian) pada ikan Nila.