bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing invasive procedures in haemophilia patients with limited resources, extended half‐life concentrates or non‐replacement therapies in 2022
Authors: Mancuso Maria Elisa , Apte Shashikant , Hermans Cedric 
Published: May 2022

AbstractNew treatment possibilities and modalities are now available globally for patients with haemophilia requiring surgery or invasive procedures.The first is the appropriate application of low‐dose protocols of clotting factor concentrates (CFC) achieving adequate perioperative haemostasis in resources constraint environments. The increasing availability of CFC through humanitarian aid programs allows more invasive surgeries to be performed for which efficacy and safety data should be more widely collected and reported.Second, extended half‐life CFC that are increasingly available in many countries represent valuable alternatives to standard half‐life products in surgical patients allowing reduced number of infusions and lower consumption, in particular for extended half‐life factor IX.Third, in the era of recently introduced nonfactor prophylaxis, some minor surgical procedures can now be performed without additional haemostatic treatment, others with few low‐dose administrations of CFC or bypassing agents. Additional factor VIII/IX or recombinant activated factor VII has proven to be safe and effective in association with emicizumab for major surgeries and it was effectively given at low doses in association with fitusiran (including activated prothrombin complex concentrate). No thrombotic complications have been reported in the surgical setting so far. A multidisciplinary team/facility remains crucial to manage major surgery in patients on prophylaxis with these new agents.
Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing ‐ Experimental evidence for a holistic treatment approach
Authors: Bluemke Anika , Ring Annika P. , Immeyer Jeannine , Hoff Anke , Eisenberg Tanya , Gerwat Wolfram , Meyer Franziska , Breitkreutz Sabrina , Klinger Lina M. , Brandner Johanna M. , Sandig Grit , Seifert Marietta , Segger Doerte , Rippke Frank , Schweiger Dorothea 
Published: May 2022

AbstractObjectiveSkin ageing is a multifactorial process involving formation of reactive oxygen species, consecutive inflammation with reduced epidermal and dermal cell viability and resulting damage to the extracellular matrix. Effective dermocosmetic treatment modalities should ideally address these hallmarks in a holistic approach. Here, we determined the corresponding activity profile of bakuchiol, a plant‐derived meroterpene, in an array of in vitro, ex vivo and in vivo studies and compared it to retinol, currently considered as gold standard in topical antiageing cosmetics.MethodsThe antioxidative capacity and power of bakuchiol and retinol were analysed by measuring 2,2′‐diphenyl‐1‐picrylhydrazyl (DPPH) reduction via its absorption decay and electron spin resonance spectroscopy, respectively. Effects on prostaglandin E2 (PGE2), macrophage migration inhibitory factor (MIF), fibroblast growth factor 7 (FGF7), collagen type I and VII (COL1A1, COL7A1), fibronectin (FN) levels as well as the metabolization of water‐soluble tetrazolium 1 (WST‐1) were determined in human dermal fibroblasts. Epidermal regeneration was assessed utilizing an in vitro wound healing model. FN protein levels were analysed ex vivo after treatment with a formulation containing bakuchiol, retinol or vehicle using suction blister fluid. Skin condition improvement was determined in vivo in a split‐face comparison study after application of bakuchiol or vehicle.ResultsIn contrast to retinol, bakuchiol demonstrated high antioxidative efficacy. Levels of PGE2 and MIF were significantly decreased by both bakuchiol and retinol. Bakuchiol but not retinol significantly increased FGF7 protein levels. WST‐1 metabolization levels were significantly augmented by bakuchiol and retinol. Bakuchiol and retinol application led to a significant augmentation of COL1A1, COL7A1 and FN protein levels. Wounds supplemented with bakuchiol but not retinol displayed a significant increase in epidermis regeneration. Clinically, areas treated with a bakuchiol‐containing formulation showed a statistically significant increase in FN protein values after a 4‐week application compared to untreated areas and areas treated with vehicle.ConclusionThese data provide evidence for the multidirectional efficacy of bakuchiol against cellular hallmarks of skin ageing. Its activity profile shares some common features with retinol but demonstrates several hitherto unknown biopositive effects in our studies, namely stimulation of the critical extracellular matrix component FN, and accelerated epidermal regeneration and wound healing.
Antiferroelectricity of NaNbO3: Single‐crystal experimental study and first‐principles calculation
Authors: Yang Dong , Zhang Yuanyuan , Wang Xuping , Li Qian , Li Jing‐Feng 
Published: May 2022

AbstractSimilar to the canonical antiferroelectric (AFE) compound PbZrO3 in Pb(Zr,Ti)O3 solid‐solutions, the presence of double hysteresis loops and that of electric field–induced phase transitions are important characteristics of NaNbO3 AFE materials; yet the phase transition behavior in the latter system is typically irreversible with the related mechanisms not fully understood. Here, we explore the phase transition mechanism of ferroelectric and AFE phases in NaNbO3 based on measurements of single crystals with different directions in conjunction with density‐functional theory (DFT) calculations. The tilting and distortion behaviors of the [NbO6] octahedra are explained by DFT, and the ion displacement in the lattice is traced. The tilting and distortion behaviors of the [NbO6] octahedra with different orientations are compared. We confirm that the tilt and distortion of the [NbO6] octahedra along the [1 1 1] direction is the main reason to improve the stability of AFE phase. This conclusion is verified by the experimental characterizations of large‐size NaNbO3 single crystals successfully obtained in this study.
In situ, direct observation of seasonal embolism dynamics in Aleppo pine trees growing on the dry edge of their distribution
Authors: Wagner Yael , Feng Feng , Yakir Dan , Klein Tamir , Hochberg Uri 
Published: May 2022

SummaryXylem embolism impairs hydraulic conductivity in trees and drives drought‐induced mortality. While embolism has been monitoredin vivoin potted plants, and research has revealed evidence of embolism in field‐grown trees, continuousin situmonitoring of cavitation in forests is lacking.Seasonal patterns of embolism were monitored in branchlets of Aleppo pine (Pinus halepensis) trees growing in a dry Mediterranean forest. Optical visualization (OV) sensors were installed on terminal branches, in addition to monthly sampling for micro computed tomography scans.We detected 208 cavitation events among four trees, which represented an embolism increase from zero toc. 12% along the dry season. Virtually all the cavitation events occurred during daytime hours, with 77% occurring between 10:00 and 17:00 h. The probability for cavitation in a given hour increased as vapor pressure deficit (VPD) increased, up to a probability of 42% for cavitation when VPD > 5 kPa.The findings uniquely reveal the instantaneous environmental conditions that lead to cavitation. The increased likelihood of cavitation events under high VPD in water‐stressed pines is the first empirical support for this long hypothesized relationship. Our observations suggest that low levels of embolism are common in Aleppo pine trees at the dry edge of their distribution.
Validation of remote atopic dermatitis severity assessment with the Eczema Area and Severity Ondex in children using caregiver‐provided photos and videos
Authors: Croce Emily A. , Rathouz Paul J. , Lopes Fabiana C. P. S. , Leszczynska Maria , Diaz Lucia Z. , Levy Moise L. , Ruth Jennifer S. , Varshney Pooja , Rew Lynn , Matsui Elizabeth C. 
Published: May 2022

AbstractBackground/ObjectivesWe sought to quantify the reliability and validity of remote atopic dermatitis (AD) severity assessment using the Eczema Area and Severity Index (EASI) applied to caregiver‐provided photos (p‐EASI) and videos (v‐EASI).MethodsChildren (0–17 years) with a physician diagnosis of AD were recruited. Caregivers took photos and a video of their child's skin. A clinician scored in‐person EASI on the same day, then p‐EASI and v‐EASI for each participant 10 days or more between ratings. Two additional clinicians scored p‐EASI and v‐EASI. Lin's concordance correlation coefficient (CCC) was employed to assess criterion validity using in‐person EASI as the gold standard. Intraclass correlation coefficients (ICCs) were calculated to assess interrater reliability of p‐EASI and v‐EASI.ResultsFifty racially and ethnically diverse children (age [mean ± SD]: 4.3 ± 4.4 years; 42% female) with a range of AD severity (EASI: 6.3 ± 6.4) and Fitzpatrick skin types (1–2: 9%; 3–4: 60%; 5–6: 31%) were enrolled and received in‐person EASI assessment. Fifty had p‐EASI and 49 had v‐EASI by the same in‐person rater, and by two additional raters. The CCC and ICC for p‐EASI were 0.89, 95% CI [0.83, 0.95] and 0.81, 95% CI [0.71, 0.89], respectively. The CCC and ICC for v‐EASI were 0.75, 95% CI [0.63, 0.88] and 0.69, 95% CI [0.51, 0.81], respectively.ConclusionsIn this diverse population with a range of skin tones, p‐EASI showed good criterion validity and good interrater reliability. v‐EASI showed moderate to good criterion validity and moderate interrater reliability. Both may be reliable and valid options for remote AD severity assessment.
The wedge sign: A possible lung ultrasound sign for pulmonary thromboembolism
Authors: Lisciandro Gregory R. , Puchot Melanie L. , Gambino Jennifer M. , Lisciandro Stephanie C. 
Published: May 2022

AbstractObjectiveTo describe the finding of the lung ultrasound (LUS) “wedge sign” in dogs with presumptive pulmonary thromboembolism (PTE).Case Series SummaryThis case series describes 2 dogs with predisposing risk factors of (1) right transvenous pacemaker terminating in its right ventricle, severe protein‐losing nephropathy, and glucocorticoid therapy, and (2) caval syndrome, each having the LUS “wedge sign” in upper lung regions, a sign consistent with pulmonary infarction and peripheral PTE.New or Unique Information ProvidedHistorically, the diagnosis of canine PTE has been made through supportive findings because the gold standard test, computed tomography pulmonary angiography (CTPA), poses limitations. The use of LUS has shown promise in people for detecting PTE, with the advantages of availability, being radiation‐ and contrast medium‐sparing, rapid (<90 s), point‐of‐care, real‐time information. Our cases suggest a possible new first‐line approach for suspecting canine PTE by using LUS and the finding of the “wedge sign” in nongravity‐dependent caudodorsal and perihilar lung regions.
El papel de los excombatientes en el proceso de DDR: ¿más allá de la participación? Un análisis desde los casos de Irlanda del Norte y Colombia
Authors: Lerma Aura , Grace Leah , Lacaze Rachel 
Published: May 2022

El Grupo de Investigación “Construcción de paz, Desarme, Desmovilización, Reintegración y Reincorporación” presenta en este artículo un análisis sobre la participación de los excombatientes en los procesos de Desarme, Desmovilización y Reintegración (DDR), con un énfasis especial en cómo ha sido la participación en el proceso de reintegración en dos países que presentan una experiencia interesante: Irlanda del Norte y Colombia. Para ello, se hace uso de un enfoque pluridisciplinario, utilizando teorías y aportes tanto de la disciplina de las relaciones internacionales en los campos de estudios específicos de paz, conflicto y DDR, como aportes de la sociología para comprender el concepto de participación.
Si bien en muchos casos se encuentra una participación simbólica en el diseño de los programas de reintegración, se analizó que a menudo esta surge desde los grupos desmovilizados que logran mantener redes de cooperación entre sus miembros. Así, instituciones públicas que brindan garantías reales de reconocimiento de esta participación permiten la construcción de un verdadero modelo participativo de reintegración. Eso importa, puesto que un mayor número de iniciativas de construcción de paz de los excombatientes y un nivel alto de participación de los excombatientes en los programas de reintegración parecen ir de la mano.
Motion Strategies for a Cobot in a Context of Intermittent Haptic Interface
Authors: Guda Vamsikrishna , Mugisha Stanley , Chevallereau Christine , Zoppi Matteo , Molfino Rezia , Chablat Damien 
Published: May 2022

Abstract
From the list of interfaces used in virtual reality systems, haptic interfaces allow users to touch a virtual world with their hands. Traditionally, the user’s hand moves the end-effector of a robotic arm. When there is no contact in the virtual world, the robotic arm is passive; when there is contact, the arm suppresses mobility to the user’s hand in certain directions. Unfortunately, the passive mode is never completely seamless to the user. Haptic interfaces with intermittent contacts are interfaces using industrial robots that move towards the user when contact needs to be made. As the user is immersed in the virtual world via a virtual reality head mounted display (HMD), he cannot perceive the danger of a collision when he changes his area of interest in the virtual environment. The objective of this article is to describe four movement strategies for the robot to be as fast as possible on the contact zone while guaranteeing safety. This work uses the concept of predicting the user’s intention through his gaze direction and the position of his dominant hand (the one touching the object) and safe-points outside the human workspace. Experiments are done and analyzed with a Pareto front with a UR5 robot, an HTC vive tracker system for an industrial application involving the analysis of materials in the interior of a car.
Nd isotopic evidence for enhanced mafic weathering leading to Ordovician cooling
Authors: Conwell Christopher T. , Saltzman Matthew R. , Edwards Cole T. , Griffith Elizabeth M. , Adiatma Y. Datu 
Published: May 2022

Abstract
It remains unclear whether waning of the volcanic degassing CO2 source or enhancement of the mafic (Ca, Mg-silicate) weathering CO2 sink, or both, caused global cooling leading to the Ordovician greenhouse–icehouse transition. We present a uniquely age-constrained and integrated Middle–Late Ordovician (470–450 Ma) continental weathering isotopic proxy data set (87Sr/86Sr and εNd(t)) from carbonate rocks of the Antelope Range of central Nevada, USA, paired with published paleotemperature proxy measurements (δ18O) of conodont apatite from the same locality. This suite of proxy records signals an increase in mafic weathering of the Taconic mountains (eastern United States) at ca. 463 Ma, which forced a period of global cooling. We adapt a 87Sr/86Sr and pCO2 mass balance approach to model CO2 drawdown during the Ordovician, and show that a combined decrease in volcanic degassing and increase in mafic weathering approximately halves pCO2 in agreement with δ18O trends and paleotemperature reconstructions.
Anthropometric markers of abdominal adiposity and its relation to dyslipidemia and insulin resistance among overweight/obese schoolchildren and adolescents
Authors: Nogueira-de-Almeida Carlos Alberto , Ferraz Ivan Savioli , Ued Fábio da Veiga , Almeida Ane Cristina Fayão , Almeida Maria Eduarda Nogueira de , Biella Diego , Del Ciampo Luiz Antonio 
Published: May 2022

Objective: to assess the relationship between anthropometric indicators and laboratorial markers of cardiovascular risk in overweight/obese children and adolescents, in order to verify whether any anthropometric indicator has a better potential for use in screening cardiovascular risk in the population.
Method: retrospective cross-sectional study enrolling 237 individuals aged 7 to 18 years. Body mass index (BMI), waist circumference (WC), waist circumference/height index (WC/H), glucose, HOMA-IR, total cholesterol (TC), LDL, HDL, triglycerides and TC/HDL and LDL/HDL indexes were obtained. Associations between anthropometric and laboratory markers were tested in contingency tables using the chi-square test. Correlations were tested by Spearman's correlation.
Results: higher WC (Freedman cutoffs) was associated with lower levels of HDL and higher score in the TC/HDL and LDL/HDL indexes, but, using +2 z-scores as the cutoff, there were associations with low HDL and higher HOMA-IR. WC/H indicator (0.5 cutoff) was not associated with any of the outcomes, but, using +2 z-scores, an association was found with HOMA-IR. Z-scores of WC, WC/H and BMI showed positive correlation with HOMA-IR, TC/HDL and HOMA-IR, respectively. Negative correlations were found between WC and WC/H z-scores with HDL. WC and WC/H z-score were related to changes in HDL and HOMA-IR.
Conclusions: there seems to be an advantage in using WC alone as a possible predictor of dyslipidemia and insulin resistance in children and adolescents. It is not possible to state that WC, WC/H or BMI measurements differ in their abilities to identify Brazilian children and adolescents with risk factors for cardiovascular diseases.
Diagnostic value of salivary gland ultrasonography for secondary Sjögren syndrome in patients with systemic lupus erythematosus
Authors: Hammam Nevin , Elzohri Mona H , Elsonbaty Amira , Eldaly Zeiad H , Hammam Osman , Tarik Dalia , Ibrahim Hamdy M , Gheita Tamer A 
Published: May 2022

Background Salivary gland ultrasound (SGUS) is a reliable technique for assessing the salivary glands in patients with primary Sjögren’s syndrome (SS); however, the role of SGUS for diagnosis of secondary SS (sSS) in patients with systemic lupus erythematosus (SLE) was not examined. Objective To assess the diagnostic value of SGUS for sSS in patients with SLE, and to investigate the relationship between SGUS findings with clinical and laboratory characteristics of patients with SLE. Patients and methods This cross-sectional study included 49 patients with SLE. The diagnosis of sSS was confirmed according to the 2016 ACR/EULAR criteria. Salivary gland US was performed for all patients and graded using a validated Hočevar scoring system. A complete clinical and laboratory workup for SLE was assessed. Schirmer’s test and the ocular staining were performed. Results Of the 49 patients with a mean age of 30.2 ± 9.6 years, 98% were female. 19 (38.8%) had sSS. SGUS changes consistent with sSS (≥17) were found in 29 (59.2%) of the patients. Patients with higher SGUS score had more sicca findings as well as positive anti-Ro, anti-La antibodies, and poorer psychological stress (p < 0.05). The SGUS (≥17) showed a sensitivity of 84.2% and a specificity of 56.7% for sSS diagnosis, with an area under the curve of 0.77 (95% CI: 0.63, 0.91). Conclusion We propose salivary gland ultrasound as a non-invasive method in the diagnostic workup for sSS in patients with SLE. Further studies to confirm the diagnostic value of SGUS in a larger sample of patients with sSS will be necessary.
Practice Patterns of Palmoplantar Pustulosis: Patient Demographics and Treatment Options
Authors: Chandler Antoinette , Wood Hannah , Nezamololama Novin , Gooderham Melinda J. 
Published: May 2022

Background Palmoplantar pustulosis (PPP) is a chronic skin condition characterized by sterile pustules on the palms and soles. This condition is more commonly reported among women and smokers causing considerable discomfort and interference with daily activities. Although there are various off-label treatment options available for PPP, there remains a demand to identify more effective and safer treatments. Objective To review the patient demographics and treatment patterns of our PPP patient population. Methods A retrospective chart review was performed at a dermatology office with two locations in Ontario, Canada. Results We identified 71 adult PPP patients. A third of patients did not return for follow up after diagnosis. Among those who returned for follow-up, 20% were managed with topical therapy alone. Of our patients who took systemic treatment for PPP, apremilast, followed by ustekinumab and guselkumab, had the greatest retention of therapy. Conclusion Targeting PDE4, IL-12/23 and IL-23 provided some benefit for our patients with PPP leading to greatest retention of therapy over time. Further investigation is required into the cause for high no-show rates and the search for effective and safe treatment options.
Genome-wide survey and expression analysis of GRAS transcription factor family in sweetpotato provides insights into their potential roles in stress response
Authors: Zhang Chengbin , Liu Siyuan , Liu Delong , Guo Fen , Yang Yiyu , Dong Tingting , Zhang Yi , Ma Chen , Tang Zixuan , Li Feifan , Meng Xiaoqing , Zhu Mingku 
Published: May 2022

AbstractBackgroundThe plant-specific GRAS transcription factors play pivotal roles in various adverse environmental conditions. Numerous GRAS genes have been explored and characterized in different plants, however, comprehensive survey on GRASs in sweetpotato is lagging.ResultsIn this study, 72 putative sweetpotatoIbGRASgenes with uneven distribution were isolated on 15 chromosomes and classified into 12 subfamilies supported by gene structures and motif compositions. Moreover, both tandem duplication and segmental duplication events played critical roles in the expansion of sweetpotato GRAS genes, and the collinearity betweenIbGRASgenes and the related orthologs from nine other plants further depicted evolutionary insights into GRAS gene family. RNA-seq analysis under salt stress and qRT-PCR detection of 12 selectedIbGRASgenes demonstrated their significant and varying inductions under multiple abiotic stresses (salt, drought, heat and cold) and hormone treatments (ABA, ACC and JA). Consistently, the promoter regions ofIbGRASgenes harbored a series of stress- and hormone-associated cis-acting elements. Among them, IbGRAS71, the potential candidate for breeding tolerant plants, was characterized as having transactivation activity in yeasts, while IbGRAS-2/-4/-9 did not. Moreover, a complex interaction relationship between IbGRASs was observed through the interaction network analysis and yeast two-hybrid assays.ConclusionsOur results laid a foundation for further functional identifications ofIbGRASgenes, and multiple members may serve as potential regulators for molecular breeding of tolerant sweetpotato.