bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural network training with limited precision and asymmetric exponent
Authors: Pietrołaj Mariusz , Blok Marek 
Published: May 2022

AbstractAlong with an extremely increasing number of mobile devices, sensors and other smart utilities, an unprecedented growth of data can be observed in today’s world. In order to address multiple challenges facing the big data domain, machine learning techniques are often leveraged for data analysis, filtering and classification. Wide usage of artificial intelligence with large amounts of data creates growing demand not only for storage and operational memory, but also computational power. Increasing complexity and variety of neural network architectures are vivid examples of such trends in the modern data-driven industry. In response to this situation, focusing on less demanding operations for inference and training of neural networks became a popular approach among many researchers to overcome resources related issues. This work aims to investigate one of the paths associated with the mentioned efficiency problems and shows the impact of floating-point precision limitation on convolutional neural networks, including experiments on various exponent and mantissa sizes. Additionally, authors explore floating-point numbers utilization and optimization techniques in the scope of neural network training. Based on conducted research a novel method of asymmetric exponent utilization is presented achieving almost identical accuracy of 32-bit floating-point parameters while training a neural network with only 12-bit variables without additional rounding.
Evaluation of antioxidant and cytotoxic activity of herbal teas from Western Himalayan region: a comparison with green tea (Camellia sinensis) and black tea
Authors: Kumari Amita , Kumar Dharmesh 
Published: May 2022

Abstract
Background
Herbal tea, known as health-promoting due to its therapeutic potential for several ailments and consumption increased over decades. The Western Himalayan region of India affluent with herbs has therapeutic values. However, these herbs have not been used in the tea and are still untouched by mankind. Therefore, the present study aimed to pioneer and manufacture herbal teas from Western Himalayan region plants.

Results
Our findings showed that total polyphenol content was ranged from 4.42 ± 0.53 to 13.37 ± 0.50% compared to green tea (GT) and black tea (BT) (13.37 ± 0.50 and 10.05 ± 0.11%) of C. sinensis, total flavonoid and total catechin content was ranged from 1.81 ± 0.67–4.68 ± 0.26% to 4.43 ± 0.28–15.17 ± 0.53% in all the herbal tea samples. Moreover, antioxidant activity was ranged in DPPH from (27.58–226.28 µg/mL) and in ABTS (14.17–117.62 µg/mL). Highest antioxidant activity was observed in GT and lowest was observed in rose tea (RT). Heatmap was made for catechin visualization in green herbal teas (GHT). Principal Component Analysis (PCA) showed the variation of amino acids in all the herbal tea samples which was found in the range from 0.82 to 2.86%. Taxus green tea (TGT) exhibited remarkable cytotoxic activity against SW480 (50.9 ± 0.7 at 200 µg/mL). Whereas, sea-buckthorn green tea (SGT) exhibited the highest activities on A549 cells (87.01 ± 1.1 at 200 µg/mL). Maximum volatile organic compounds (VOCs) were identified in lemongrass black tea (LBT) (96.23%), namely, geranial, levoverbenone, pulegone, l-linalool and cineol. In addition, the sensory analysis revealed that herbal tea shows sweet and better taste with high sensory attributes.

Conclusions
Current study revealed that the Western Himalayan region plants could be used as herbal tea with additional health benefits. The prepared herbal teas can be used in nutraceuticals as a beverage and a new dietary source for bioactive compounds.

Graphical Abstract
Laboratory construction and curation scheme for returned samples of the chang’e-5 mission
Authors: Yang Hongwei , Yang Ruihong , Wang Qian 
Published: May 2022

AbstractThe analysis of samples returned from a planetary body is important to understand the origin, composition, evolution, and interactions with space or atmospheric weathering of the planet. In particular, pristine rocks, which are not affected by weathering, can be collected during sampling work. The analysis of samples will significantly promote the calibration, verification, and interpretation of remote sensing data and will improve the knowledge of interior materials using geophysical measurements. The Chang’e-5 lander, the first Chinese science project involving the return of lunar samples, launched on November 24, 2020 and drilled a core sample that is almost 1 m long, and acquired less than 2 kg during this mission. Because of the preciousness of the returned samples, the CLESEC (China Lunar Exploration and Space Engineering Center) is planning to construct at least two laboratories, determine regulations for preserving samples from the Moon and other planets in future missions and develop non-damaging and/or minimally damaging technologies to analyze the returned samples. The CLESEC also announced standardized technologies and documentary regulations for preservation, measurement, and sharing schemes with scientists around the world. Based on the Apollo experiences, we have established detailed requirements and standardized conditions for constructing laboratories and curation with the aid of advanced technologies. We also discuss six potential demands for future sampling missions. Finally, we developed high-level criteria for future returning sample missions and relative curations that are beneficial to Chang’e-5 research and as well as preparation for other extraterrestrial samples in the near future.
The Makkah–Madinah Transform Zone: a relic rift-to-rift continental transform formed during early Arabia–Nubia plate separation
Authors: Aldaajani Thamer , Furlong Kevin P. 
Published: May 2022

AbstractThe continental-rifting of Arabia from Nubia, and the initial evolution of the Red Sea spreading center includes many of the continental-rifting to ocean-spreading processes, in particular transform formation, and the eventual development of a mid-ocean ridge. The recent occurrence of this rifting and the multi-stage evolution of the plate boundary has preserved of key components of the early-stage plate boundary development. We find that the Makkah–Madinah Transform Zone (MMTZ) represents a rift-to-rift continental transform fault that served as a primary component of the initial plate boundary between Arabia and Nubia. It connected the more evolved southern Red Sea mid-ocean ridge to the initially dominant Sirhan Rift. During this time, the MMTZ served as a primary lithospheric-scale boundary between the Arabia and Nubia plates. The Sirhan Rift and the MMTZ connection to the Red Sea spreading center was mostly abandoned with the development of the Dead Sea fault, and localization of extension in the present-day northern Red Sea. The transition to the present tectonic setting suggests an ephemeral rift–rift–transform triple junction within the central Red Sea connecting the localized southern Red Sea rift, a developing northern Red Sea rift, and the MMTZ transform.
Spontaneous formation of boron nitride nanotube fibers by boron impurity reduction in laser ablation of ammonia borane
Authors: Bae Dong Su , Kim Chunghun , Lee Hunsu , Khater Omar , Kim Keun Su , Shin Homin , Lee Kun-Hong , Kim Myung Jong 
Published: May 2022

AbstractHighly crystalline and few-walled boron nitride nanotubes (BNNTs) had been synthesized by laser ablation using only ammonia borane as a precursor. As a molecular precursor, ammonia borane supplied both B and N atoms with a ratio of 1:1, and BNNTs were formed via the homogeneous nucleation of BN radicals, not the growth from boron nano-droplets, which is a generally accepted growth mechanism of the laser-grown BNNTs. Owing to the absence of amorphous boron impurities, the van der Waals interaction among BNNTs became effective and thus a BNNT fibers was formed spontaneously during the BNNT synthesis. The BNNT growth and the subsequent fiber formation are found to occur only at high pressures of a surrounding gas. The mechanism behind the critical role of pressure was elucidated from the perspective of reaction kinetics and thermal fluid behaviors. A polarized Raman study confirmed that the BNNT fiber formed exhibits a good alignment of BNNTs, which implies great potential for continuous production of high-quality BNNT fibers for various applications.
The mid-term and long-term effects of tourniquet use in total knee arthroplasty: systematic review
Authors: Rafaqat Wardah , Kumar Sudhesh , Ahmad Tashfeen , Qarnain Zul , Khan Khalid Saeed , Lakdawala Riaz Hussain 
Published: May 2022

Abstract
Purpose
A tourniquet is routinely used during total knee arthroplasty (TKA) to reduce intra-operative hemorrhage, though surgery without a tourniquet is becoming popular. To address concerns about the effect of blood at cement interfaces on long-term implant stability, we conducted a systematic review among patients undergoing total knee arthroplasty to determine if TKA with a tourniquet, compared to TKA without a tourniquet or with reduced tourniquet duration, is associated with better mid-term and long-term implant stability.

Methods
A literature search was conducted without language restriction in PubMed, Cochrane database and Web of Science from conception to 17th March, 2021. Prospective cohorts, randomized and observational, that compared tourniquet use with a control group, followed patients for 3 months or more and reported outcomes concerning implant stability, limb function, pain and inflammation. Article selection, quality assessment according to the Revised Cochrane risk assessment scale and Newcastle Ottawa Scale, and data extraction were conducted in duplicate. PROSPERO: CRD42020179020.

Results
The search yielded 4868 articles, from which 16 randomized controlled trials (RCT) and four prospective cohort studies, evaluating outcomes of 1884 knees, were included. Eleven RCTs were evaluated to be low overall risk of bias, five RCTs had some concerns and four cohort studies were good quality. Few studies showed benefits of tourniquet use in mid-term implant stability (1/6), pain (1/11) and limb inflammation (1/5), and long-term implant stability (1/1). One study reported a significantly improved range of motion (1/14) while another reported significantly reduced quadriceps strength (1/6) in the tourniquet group. The remaining studies reported non-significant effect of tourniquet use.

Conclusion
Although few studies indicated benefits of tourniquet use in mid-term pain, limb inflammation, implant loosening and function, and long-term implant loosening, the majority of studies report no significant advantage of tourniquet use in total knee arthroplasty.
Fine-tuned regulation of photosynthetic performance via γ-aminobutyric acid (GABA) supply coupled with high initial cell density culture for economic starch production in microalgae
Authors: Pan Yunyun , Shen Yuhan , Zhang Haoyu , Ran Xiuyuan , Xie Tonghui , Zhang Yongkui , Yao Changhong 
Published: May 2022

AbstractMicroalgal starch is considered as renewable and sustainable feedstock for biofuels and biorefinery. High cell density culture is favourable for photoautotrophic starch production in microalgae in the aspects of productivity and economy, but it often encounters low starch content or extra stress exposure that limits the production. This study aimed to economically enhance photosynthetic starch production from CO2 fixation in a green microalga Tetraselmis subcordiformis by regulating photosynthetic stress status with a signalling molecule γ-aminobutyric acid (GABA) combined with the application of high initial cell density culture. By increasing initial cell density (ICD) from the normal of 1.1 g L−1 (NICD) to as high as 2.8 g L−1 (HICD), the starch content, yield, and theoretical productivity were improved by 7%, 63%, and 42%, respectively. The addition of GABA under HICD resulted in 14%, 19%, and 26% of further enhancement in starch content, yield, and theoretical productivity, respectively. GABA exhibited distinct regulatory mechanisms on photosynthesis and stress status under HICD relative to NICD. GABA augmented excessive light energy absorption and electron transfer through photosystem II that reinforced the photoinhibition under NICD, while alleviated the stress reversely under HICD, both of which facilitated starch production by enabling a suitable stress status while simultaneously maintaining a sufficient photosynthetic activity. The increase of ICD and/or GABA supply particularly boosted amylopectin accumulation, leading to the changes in starch composition and was more favourable for fermentation-based biofuels production. Preliminary techno-economic analysis showed that the highest net extra benefit of 9.64 $ m−3 culture could be obtained under HICD with 2.5 mM GABA supply where high starch content (62%DW) and yield (2.5 g L−1) were achieved. The combined HICD-GABA regulation was a promising strategy for economic starch production from CO2 by microalgae for sustainable biomanufacturing.
Graphical Abstract
Identifying factors that may influence the classification performance of radiomics models using contrast-enhanced mammography (CEM) images
Authors: Sun Yuqi , Wang Simin , Liu Ziang , You Chao , Li Ruimin , Mao Ning , Duan Shaofeng , Lynn Henry S. , Gu Yajia 
Published: May 2022

Abstract
Background
Radiomics plays an important role in the field of oncology. Few studies have focused on the identification of factors that may influence the classification performance of radiomics models. The goal of this study was to use contrast-enhanced mammography (CEM) images to identify factors that may potentially influence the performance of radiomics models in diagnosing breast lesions.

Methods
A total of 157 women with 161 breast lesions were included. Least absolute shrinkage and selection operator (LASSO) regression and the random forest (RF) algorithm were employed to construct radiomics models. The classification result for each lesion was obtained by using 100 rounds of five-fold cross-validation. The image features interpreted by the radiologists were used in the exploratory factor analyses. Univariate and multivariate analyses were performed to determine the association between the image features and misclassification. Additional exploratory analyses were performed to examine the findings.

Results
Among the lesions misclassified by both LASSO and RF ≥ 20% of the iterations in the cross-validation and those misclassified by both algorithms ≤5% of the iterations, univariate analysis showed that larger lesion size and the presence of rim artifacts and/or ripple artifacts were associated with more misclassifications among benign lesions, and smaller lesion size was associated with more misclassifications among malignant lesions (all p <  0.050). Multivariate analysis showed that smaller lesion size (odds ratio [OR] = 0.699, p = 0.002) and the presence of air trapping artifacts (OR = 35.568, p = 0.025) were factors that may lead to misclassification among malignant lesions. Additional exploratory analyses showed that benign lesions with rim artifacts and small malignant lesions (< 20 mm) with air trapping artifacts were misclassified by approximately 50% more in rate compared with benign and malignant lesions without these factors.

Conclusions
Lesion size and artifacts in CEM images may affect the diagnostic performance of radiomics models. The classification results for lesions presenting with certain factors may be less reliable.
Impact of stratospheric ozone on the subseasonal prediction in the southern hemisphere spring
Authors: Oh Jiyoung , Son Seok-Woo , Choi Jung , Lim Eun-Pa , Garfinkel Chaim , Hendon Harry , Kim Yoonjae , Kang Hyun-Suk 
Published: May 2022

AbstractAntarctic ozone has been regarded as a major driver of the Southern Hemisphere (SH) circulation change in the recent past. Here, we show that Antarctic ozone can also affect the subseasonal-to-seasonal (S2S) prediction during the SH spring. Its impact is quantified by conducting two reforecast experiments with the Global Seasonal Forecasting System 5 (GloSea5). Both reforecasts are initialized on September 1st of each year from 2004 to 2020 but with different stratospheric ozone: one with climatological ozone and the other with year-to-year varying ozone. The reforecast with climatological ozone, which is common in the operational S2S prediction, shows the skill re-emergence in October after a couple of weeks of no prediction skill in the troposphere. This skill re-emergence, mostly due to the stratosphere–troposphere dynamical coupling, becomes stronger in the reforecast with year-to-year varying ozone. The surface prediction skill also increases over Australia. This result suggests that a more realistic stratospheric ozone could lead to improved S2S prediction in the SH spring.
Ventricular septal rupture after blunt chest trauma: a case report
Authors: Tochii Masato , Watanuki Hirotaka , Sugiyama Kayo , Futamura Yasuhiro , Ishikawa Hiroshi , Matsuyama Katsuhiko 
Published: May 2022

AbstractCardiac injury, including myocardial contusion and valvular damage, is a common complication of blunt chest trauma; however, traumatic ventricular septal rupture is a rare complication. We encountered a rare case of ventricular septal rupture following blunt chest trauma that was successfully repaired by emergency surgery. The mechanism underlying rupture may involve acute compression of the heart between the sternum and the vertebral column when the ventricle is filled, thereby causing a sudden increase in intraventricular pressure and leading to septal rupture. Emergency operation should be considered in cases of large defects and hemodynamic instability.
Approaches for monitoring and treating cardiomyopathy among cancer survivors following anthracycline or thoracic radiation treatment
Authors: Delavar Arash , Boutros Catherine , Barnea Dana , Schaffer Wendy L. , Tonorezos Emily S. 
Published: May 2022

Abstract
Background
Anthracycline chemotherapy and thoracic radiation therapy (RT) are known causes of cardiomyopathy among cancer survivors, however, management guidelines for this population are lacking. In this study we describe our single institution management approach for cancer survivors with low left ventricular ejection fraction (LVEF) secondary to cancer treatment.

Methods
We conducted a retrospective descriptive study of childhood and young adult (CAYA) cancer survivors in the Adult Long-Term Follow-Up Clinic at Memorial Sloan Kettering Cancer Center enrolled between November 2005 and July 2019. Those included were treated with anthracycline and/or thoracic RT as a part of their cancer therapy and had recorded a LVEF of < 55% on at least one post-treatment echocardiogram. Details regarding survivor characteristics, screening, and management were abstracted. Differences in management approaches among survivors with LVEF of 50–54.9%, 40–49.9%, and < 40% were described. Qualitative management approaches were abstracted as well.

Results
Among 668 CAYA survivors in the initial cohort, 80 were identified who had received anthracycline and/or thoracic RT and had a LVEF of < 55%. Median age at cancer diagnosis was 16.1 years, median time from cancer diagnosis was 25.8 years, and 55% of survivors were female. Cardiology referrals, nuclear stress tests, multi-gated acquisition scans, angiograms, echocardiograms, treatment with angiotensin converting enzyme inhibitors or receptor blockers, beta-blockers, diuretics, aldosterone antagonists, aspirin, and insertion of pacemaker or implantable cardioverter-defibrillators differed by LVEF category. Documentation suggested uncertainty regarding management of survivors with borderline low-LVEF, with low-LVEF that improved on follow-up, and with subsequent cancers requiring additional treatment.

Conclusions
The management of CAYA cancer survivors with low-LVEF largely followed guidelines designed for the general population, however, uncertainty remains for issues specific to cancer survivors. Cardiomyopathy management guidelines that address issues specific to cancer survivors are needed.
Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital
Authors: Liu Zhi-ming , Liao Chih-yi , Zhang Heng , Han Zhe , Wang Jun-mei , Ma Zhen-yu , Li Chun-de , Gong Jian , Liu Wei , Sun Tao , Tian Yong-ji 
Published: May 2022

Abstract
Background
To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.

Methods
From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. We analyzed age-related gender preferences, tumor locations, and the histological grades of the tumors. In addition, the epidemiological characteristics of the five most common intracranial tumors were compared to the previous studies.

Results
In this study, intracranial and spinal tumors account for 96.4% (3066) and 3.6% (114) of all tumors, with a preponderance of supratentorial tumors (57.9%). Among all pediatric patients, low-grade tumors comprise 67.1% (2 135). The integral gender ratio of males to females is 1.47: 1 and the average age of patients is 7.59 years old. The five most common intracranial tumors are craniopharyngioma (15.4%), medulloblastoma (14.3%), pilocytic astrocytoma (11.8%), diffuse astrocytoma (9.8%), and anaplastic ependymoma (4.8%).

Conclusions
Due to the lack of national data on childhood brain tumors, we used a large nationally representative population sample based on the largest pediatric neurosurgery center in China. We analyzed the data of the past 5 years, reflecting the incidence of CNS tumors in Chinese children to a certain extent, and laying a data foundation for subsequent clinical studies.
Visual communication via the design of food and beverage packaging
Authors: Spence Charles , Van Doorn George 
Published: May 2022

AbstractA rapidly growing body of empirical research has recently started to emerge highlighting the connotative and/or semiotic meanings that consumers typically associate with specific abstract visual design features, such as colours (either when presented individually or in combination), simple shapes/curvilinearity, and the orientation and relative position of those design elements on product packaging. While certain of our affective responses to such basic visual design features appear almost innate, the majority are likely established via the internalization of the statistical regularities of the food and beverage marketplace (i.e. as a result of associative learning), as in the case of round typeface and sweet-tasting products. Researchers continue to document the wide range of crossmodal correspondences that underpin the links between individual visual packaging design features and specific properties of food and drink products (such as their taste, flavour, or healthfulness), and the ways in which marketers are now capitalizing on such understanding to increase sales. This narrative review highlights the further research that is still needed to establish the connotative or symbolic/semiotic meaning(s) of particular combinations of design features (such as coloured stripes in a specific orientation), as opposed to individual cues in national food markets and also, increasingly, cross-culturally in the case of international brands.