bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actinomyces ruminis sp. nov., an obligately anaerobic bacterium isolated from the rumen of cattle
Authors: Lanjekar Vikram B. , Hivarkar Sai Suresh , Vasudevan Gowdaman , Joshi Akshay , Dhakephalkar Prashant K. , Dagar Sumit Singh 
Published: September 2022

Abstract
An obligately anaerobic, rod-shaped, Gram-stain-positive, non-spore-forming, non-motile bacterial strain; designated as CtC72T was isolated from the rumen of cattle. The 16S rRNA gene sequence similarity of less than 98.65% revealed the strain as a member of the genus Actinomyces, nearest to but distinct from Actinomyces qiguomingii DSM 106201T, Actinomyces ruminicola DSM 27982T, Actinomyces procaprae JCM 33484T, Actinomyces succiniciruminis TISTR 2317, Actinomyces glycerinitolerans TISTR 2318. The low values of digital DNA-DNA hybridization (< 70%) and average nucleotide identity (< 95%) further highlighted the distinctive nature of strain CtC72T from its closest relatives. The strain CtC72T could grow at temperatures between 30–50°C (optimum 40°C), pH between 6.0–9.0 (optimum 7.5-8.0), and NaCl between 0-1.5% (optimum 0%). The strain hydrolysed cellulose and xylan and utilised a range of mono-, di-, and oligo-saccharides as a source of carbon and energy. Glucose fermentation resulted in acetic acid and formic acid as major metabolic products, while propionic acid, lactic acid, and ethanol as minor products along with CO2 production. The DNA G + C content of strain CtC72T was 68.40 (mol%, wet lab), and 68.05 (%, digital). Major cellular fatty acids (> 10%) were C16:0, C18:1 ω9c, and C18:1 ω9c DMA. Based on this data, we propose that strain CtC72T be classified as a novel species, Actinomyces ruminis sp. nov., under the genus Actinomyces. The type strain is CtC72T (= KCTC 15726T = JCM 32641T = MCC 3500T).
Risk factors and haemato-biochemical parameters associated with Theileria equi infection in equids in Central Italy
Authors: Nardini Roberto , Iacoponi Francesca , Cersini Antonella , Rosone Francesca , Scaramozzino Paola , Lai Olga , Barlozzari Giulia , Viola Maria Rita , Altigeri Alessia , Scicluna Maria Teresa 
Published: September 2022

Abstract

Background: Equine piroplasmosis is a tick-borne disease affecting equids caused by protozoa belonging to two genus named Theileria and Babesia, causing losses in the horse industry and constraint to the international movement. In endemic areas, clinical diagnosis is difficult because signs are not pathognomonic. Identifying the associated risks factors and the most suitable laboratory analyses are required to prevent the disease, confirm the diagnosis and assess therapy.
Methods: A total of 438 horse and donkey samples were collected by practitioners during their clinical activities. The anamnestic information were collected by a standardized form. The samples were screened for piroplasmosis and other infectious diseases in differential diagnosis and haemato-biochemical parameters, and thus assigned to three groups: confirmed cases of T. equi, unconfirmed suspects and controls. Statistical analysis was performed to detect differences among groups regarding anamnestic data and haemato-biochemical parameters.
Results: Among anamnestic variables, only age (> 6 years) increases the probability of infection compared to the controls, while ectoparasitic treatments seem to have a protective effect. A decrease in platelet count was the only haemato-biochemical parameter associated with T. equi infection.
Conclusions: This study confirms the diagnosis of T. equi infection as an issue, for similarities regarding anamnesis and laboratory findings with other diseases. Moreover, it focuses the attention on prevention measures and good management practices that can reduce the spread of the disease, together with regular laboratory checks, useful to early detect the parasite and assess and monitor the therapy.
Characteristics of donor vessels and cerebral blood flow in the chronic phase after combined revascularization surgery for moyamoya disease
Authors: Mamiya Takashi , Araki Yoshio , Taoka Toshiaki , Fujita Naotoshi , Yokoyama Kinya , Uda Kenji , Muraoka Shinsuke , Kanamori Fumiaki , Takayanagi Kai , Ishii Kazuki , Nishihori Masahiro , Izumi Takashi , Kato Katsuhiko , Saito Ryuta 
Published: September 2022

Abstract

This study aimed to determine whether donor vessel development after combined revascularization surgery for moyamoya disease (MMD) was related to cerebral blood flow (CBF) changes. We retrospectively reviewed the charts of 11 adults (12 hemispheres) and 13 children (19 hemispheres) who underwent combined revascularization in our department. The total vessel cross-sectional area (TVA) was the sum of the cross-sectional areas of the superficial temporal, middle meningeal, and deep temporal arteries imaged using time-of-flight magnetic resonance angiography. The ipsilateral relative CBF (RCBF) on the brain surface in the craniotomy area was calculated using single-photon emission computed tomography. The preoperative and postoperative ratios of the TVA and RCBF were defined as ΔTVA and ΔRCBF, respectively. Finally, we investigated the correlation between ΔTVA and ΔRCBF in adults and children. TVA and RCBF increased significantly after surgery regardless of the age group. The adult group had significantly higher ΔRCBF values than did the pediatric group (p < 0.01, r = −0.44). However, ΔTVA was not significantly correlated with ΔRCBF in either group. Thus, the increase in CBF was not correlated with changes in the measurable total donor vessel area. The findings suggest that postoperative development of major bypass vessels does not necessarily result in increased CBF.
WITHDRAWN: Physicochemical Characteristics of Silico Manganese Slag as A Recycling Construction Material: A Systematic Review
Authors: Wong NgieHing , Siung Choo Ching , Chai Changsaar , Khoso Ali Raza , Bamgbade Jibril Adewale , Sambo Ratanak 
Published: September 2022

Abstract
Silico Manganese (SiMn) slag is a by-product of ferromanganese and silicomanganese alloy production. The large quantities of these slags have caused several challenges in disposing of them without polluting our environment. This study aims to review the physicochemical characteristics and the recycling applications of SiMn slag as construction materials. In continuation to this, a systematic review is conducted. Twenty articles were shortlisted and later assessed in terms of their physicochemical characteristics and the reutilization benefits of SiMn slag as construction materials. It is found from the literature that SiMn slag from five countries possesses similar chemical compositions such as SiO2, Al2O3, CaO, MnO, MgO, FeO+Fe2O3, and K2O+Na2O at similar quantities. Two types of slags have been identified, which are air-cooled and water-quenched SiMn slag that exhibit different physical characteristics for reutilization. Recently, studies have successfully processed SiMn slag into brick, binder/cement, paste, mortar, concrete, backfill materials, and manganese extracts. The consideration of using SiMn slag as a recycled construction material falls on cooling methods, moisture, fineness (particle size), equipment, energy, and cost. Research investigated that there are also four steps to improve the reutilization of SiMn, namely (i) incoming waste, (ii) pre-treatment, (iii) physical/chemical treatment, and (iv) products. The investigation further offers various implications and suggestions for further studies such as developing industry-scale recycling applications, environmentally friendly landfilling methods for SiMn slag, and the practicality and feasibility of SiMn-slag-based products in real projects.
Signature of Sinking Streams on Calcarenite Rock Study Using Geophysical and Geochemical Investigation in Ayankulam Area, South Tamilnadu, India
Authors: A Antony Ravindran , A Antony Alosanai Promilton , J Vinoth Kingston , S Richard Abishek , K Aswin S , R Abinaya 
Published: September 2022

Abstract
Ayankulam is the trending one recently during the 2021 monsoon of India. Despite a large supply of water from the Nambiar canal for five days, the village's fabled well was unable to fill. When the district collector and IIT team came, they assessed the community and noted that the wells' geological makeup was classified as a karst formation (as per e-news sited in The New Indian Express dated 03/12/2021). There might be some sinking stream that might link this well. Karst topography of calcarenite rocks is the reason for groundwater movement beneath the subsurface for not filling the well. One of the most crucial elements of nature's water supplies is groundwater. Groundwater has to be explored more thoroughly since demand for it rises as the population grows. To determine the existence of usable groundwater for irrigation purposes in the study area Geophysical (Azimuthal square array method and Magnetotelluric method) and Geochemical investigations were done. The Azimuthal Square array method covers 360º coverage of subsurface resulting in fracture orientation of rock to determine the weak/strong zones in different rock types. The Magnetotelluric method scans the subsurface rock and provides information about Geological formation, Weak zone where water oozes out, depth and movement of groundwater. Water samples were collected in and around the “Sinking Stream” origin well and its associated open and tube wells from the study area. The combination of Square Array, MT, Water quality, and quantity study focuses on the Trapped Aquifer system of sinking streams in all water bodies and wells. The movement of groundwater seems to be increasing in Seashore areas such as Uvari and Karikovil are identified relating its water samples from deep bore wells quality and sinking stream water quality. The heavy rainfall and hydrostatic pressure of predominant rock on eroded Calcarenite lime formation create water “Dry fall out” resulting in Sinking streams in the Ayankulam area.
Premotor Function in Interpersonal Bimanual Coordination: Neural Responses to Varying Frequencies and Spatio-Temporal Relationships
Authors: Li Yanan , Niu Ruoyu , Liu Lei , Liu Ying 
Published: September 2022

Abstract
Background: Interpersonal movement coordination is an important aspect of daily life. Behavioral studies have found that rhythmic bimanual coordination of movement is mainly influenced by two factors, spatio-temporal relationship and frequency of movements. How these factors affect action coordination at the neural level needs further exploration.
Methods: Participants were asked to perform symmetric or alternating hand movements under conditions of different spatio-temporal relationships (symmetric, alternating) and frequencies. A multi-channel, continuous wave, functional near-infrared spectral (fNIRS) imaging instrument was used to monitor hemodynamic activity while 16 pairs of volunteers performed the task.
Results: Behaviorally, as indexed by phase locking value, movements were more stable in symmetric mode than in alternate mode. With increasing frequency, symmetric mode became more unstable; in contrast, alternating mode became more stable at higher frequencies, suggesting phase transition. Activation in brain regions of interest was much stronger in symmetric mode as compared with alternate mode. In alternate mode, but not symmetric mode, [HbO] varied with frequency.
Conclusion: Interpersonal bimanual coordination involves activity in premotor areas (premotor cortex, supplementary motor area, and frontal eye fields). More oxygen is consumed in these regions in alternating mode than in symmetric mode.
Switchable capillary and drainage containers for programmable three-dimensional liquid manipulation
Authors: Zhang Yiyuan , Huang Zhandong , Cai Zheren , Qin Feifei , Cai Xiaobing , Xiao Junfeng , Carmeliet Jan , Song Yanlin , Yang Jun 
Published: September 2022

Abstract
Capillarity-guided liquid manipulations are ubiquitous in nature. Multifarious bioinspired capillary microfluidic devices have been developed to control different liquid behaviors. However, current capillary systems still suffer substantial limitations in flexible three-dimensional (3D) liquid manipulation, especially in reversible liquid capture and release, programmable 3D liquid patterning, and large-scale multi-liquid manipulation. Here, we propose “switchable capillary and drainage containers” composed of connected frame units for versatile programmable 3D liquid manipulation. A small difference in the frame connections induces vastly distinct liquid behaviors, namely, liquid capture in capillary containers and liquid release in drainage containers. Liquid capture or release can be reversibly switched by establishing or breaking the liquid continuity between containers. Using predefined frame connections allows programmable 3D patterning of unary and binary liquids, enabling parallel multi-variable studies. The containers are proved to be powerful fluidic platforms with applications including reversible capillary sampling and release, high-flow evaporative humidifier, and efficient CO2 capture. We envision that the containers will open broad applications in materials science, interfacial chemistry, and biomedical research. Main text
Traumatic Incarceration of a Right Inguinal Hernia Due to a Deceleration Injury Following Airborne Operations: A Case Report
Authors: Donahue Alec K. , Kaplan Adam Jared 
Published: September 2022

Abstract
Anterior abdominal wall hernias are a common and well described surgical pathology occurring in an estimated 5–10% of the population. Here, we describe a patient found to have acute incarceration of omentum through a patent processus vaginalis secondary to a high energy deceleration injury following airborne operations. Many studies and meta-analysis have been performed to examine the association between occupational risk factors, patient factors, and precipitating events leading to acute hernia and found insufficient evidence to support a causal link between single strenuous events and acute hernia formation. This case highlights and documents the occurrence of an isolated acute inguinal hernia with omental incarceration in the setting of patent processus vaginalis secondary to a single deceleration injury, contradicting the widely held notions described above.
Performance analysis of a queueing system based on working vacation with repairable fault in the P2P network
Authors: Wang Shunzhi , Ma Zhanyou , Wang Rong , Fang Wenming 
Published: September 2022

Abstract
Nowadays, P2P (Peer-to-Peer) absolutely dominates the Internet as a traffic in content distribution and sharing service, the issue of energy consumption has emerged as a hot issue. This paper combines the basic theoretical knowledge of queueing theory with the currently more popular hybrid P2P network structure model. In order to address the problem of wasted energy consumption generated by unnecessary online behavior of nodes, the working sleep mechanism for the serving nodes is introduced, and the synchronous multiple working vacation strategy is also adopted to decrease the system energy consumption. In the meantime, negative customer and feedback strategies are introduced. Then a queueing model with working vacation and repairable fault is built, which used to simulate the resource transmission process of P2P and to study the performance of P2P sharing system. The steady-state probability vector is derived by employing quasi-birth-and-death process (QBD) and matrix-geometric solution method. And the expressions for system performance indicators, such as the average delay, are obtained by employing Gauss-Seidel iteration method. Through numerical experiments, the performance indicators of the P2P resource sharing system are studied, which provides a theoretical basis to decrease online energy consumption of nodes in the P2P network system. And through employing Nash equilibrium and social optimal strategy, the value of the social maximum benefit under the social optimization is obtained.
Three Dimensional Evaluation of Skeletal Effects of Two Non- Compliance Appliances in the Treatment of Growing Skeletal Class Iii Patients (a Randomized Controlled Clinical Trial)
Authors: Abbas Bassant A. , Yousry Tarek N. , Marzouk Wessam W. , Abdullah Essam M. 
Published: September 2022

Abstract
Objective
Study was conducted to 3D evaluate skeletal effects of two different intraoral force application systems for treating skeletally growing ClassIII patients(RCT).
Material and Methods
33 patients recruited and randomly allocated between three groups: GroupI(n = 11)treated with CS2000(CSgroup/ pulling force), GroupII(n = 11)treated with reversed Forsus Fatigue Resistant(RFgroup/ pushing force) and GroupIII(n = 11)untreated control(negative control). A CBCT taken before treatment(T0) and after gaining a 2mm overjet or after observation period of 6months(T1). Skeletal measurements were assessed and compared between groups. Within group comparisons were done using Wilcoxon Sign Rank test.
Results
Sagittaly in RFgroup, OLp-Apt increased by3.60mm, OLp-Bpt decreased by-2.50mm and OLp-Pg decreased as well by-2.00mm(P < 0.0001). In the same sagittal dimension for CSgroup, OLp-Apt increased by3.10mm, OLp-Bpt decreased by-1.10mm and OLp-Pg decreased as well by-1.00mm. Wits appraisal was increased by5.00mm and5.50mm in RF and CSgroup accordingly(P < 0.0001). There was an increase in OLs-Apt in treatment groups by3.80mm in RFgroup and5.00mm in CSgroup(P < 0.0001). Vertically there was a statistical significant difference between two groups. The ANS-Me decreased in RFgroup by-0.70mm and increased in CSgroup by2.00mm. Both treatment groups demonstrated an increase in SNAangle(2.6°in RFgroup and2.5° in CSgroup), decrease in SNBangle − 1.00°in RFgroup and-2.00°in CSgroup, hence increase in ANBangle.(P < 0.0001)
Conclusions
CS2000 spring and reversed Forsus Fatigue Resistance device promoted forward maxillary advancement in average of 5months. Both appliances gave close effects to bone anchored maxillary protraction devices and functional appliances, removing compliance factor out of the equation.
Clinical relevance:
Short term correction of growing skeletal class III using either one of novel techniques give positive skeletal results.
Trial registration:
Registered in clinicaltrial.gov (NCT04825951) in 01/04/2019, taking the approval of institutional review board at the Faculty of Dentistry, Alexandria University protocol record 070320212.
The burden and trends of multiple myeloma worldwide from 1990 to 2019
Authors: Ou Zejin , Gao Yunxia , Yu Danfeng , Jiang Diwei , Cui Jiaxin , Zhang Yuxia , Tang Shihao , Duan Danping , Wang Zhi 
Published: September 2022

Abstract
Background
Multiple myeloma (MM) is a common malignant disease of the bone marrow. The burden and trends of MM were systematically analyzed globally, which would inform health strategies.
Methods
Data of the MM burden was explored from the Global Burden of Disease 2019. Trends in the age-standardized rate (ASR) of the MM burden were calculated using estimated annual percentage change (EAPC).
Results
Globally, the incident cases of MM increased 136.10% since 1990, and reached 1556.88×102 in 2019. The overall incident ASR (/100,000 population) increased from 1.73 in 1990 to 1.92 in 2019, by an annual average 0.25% increase over the past thirty years (EAPC = 0.25, 95% confidence interval [CI]: 0.15 to 0.35). Increasing incident trends also occurred in most regions and countries, particularly Jamaica and Belarus, in which the respective EAPCs were 4.15 (95%CI: 3.41 to 4.90) and 3.25 (95%CI: 2.99 to 3.51). In 2019, MM caused 1134.74×102 deaths, and 24972.05×102 disability adjusted-life years (DALYs) globally. Trends in the overall ASR of DALYs minorly declined from 1990 to 2019 (EAPC = -0.16, 95%CI: -0.23 to -0.09), whereas that of death was relatively stable. Increasing trends in ASR of death and DALYs were observed in most regions and countries, except in high sociodemographic index (SDI) settings.
Conclusions
The MM burden was heterogeneous across regions and countries and its changing trends were associated with sociodemographic factors. Cost-effective measures will still be needed to reduce the MM burden.
The effect of chitosan-assembled graphene oxide on the microstructure and mechanical properties of the biodegradable polycaprolactone nanocomposites
Authors: Shahsavar Fahimeh , Babaei Amir 
Published: September 2022

Abstract
The present study explores the effect of chitosan-assembled graphene oxide on the microstructure and mechanical properties of polycaprolactone nanocomposites. To this end, firstly, CS-assembled graphene oxide sheets were synthesized. Subsequently, the effect of adding various amounts of GO-CS nanohybrid and GO sheets on the rheological and mechanical performance of polycaprolactone (PCL)-based nanocomposites was investigated. It was observed that the incorporation of GO sheets caused dual roles based on the amount of addition: the motion-limiting role and the lubricating role. Additionally, the tensile strength and Young’s modulus of the PCL nanocomposite films containing GO-CS nanohybrid and GO sheets increased as compared to pure PCL, while its influence in terms of elongation at break was the opposite. Chitosan assembly to conventional nanoparticles (e.g., GO) was found as an interesting approach for the simultaneous enhancement of mechanical performance and processability of polymer matrices for a vast range of applications, especially in packaging and tissue engineering.
Synaptotagmin 4 supports spontaneous axon regeneration after spinal cord injury
Authors: Higuchi Kyoka , Tanabe Shogo , Kato Yuki , Uyeda Akiko , Kawahara Yukio , NARITA Minoru , Muramatsu Rieko 
Published: September 2022

Abstract
Injuries to the central nervous system (CNS) can cause severe neurological deficits. Axonal regrowth is a fundamental process for the reconstruction of compensatory neuronal networks after injury; however, it is extremely limited in the adult mammalian CNS. In this study, we conducted a loss-of-function genetic screen in cortical neurons combined with a web-resource-based phenotypic screen and identified synaptotagmin 4 (Syt4) as a novel regulator of axon elongation. Silencing Syt4 in primary cultured cortical neurons inhibits neurite elongation, with changes in gene expression involved in signaling pathways related to neuronal development. In a spinal cord injury model, inhibition of Syt4 expression in cortical neurons prevented axonal sprouting of the corticospinal tract, as well as neurological recovery after injury. These results provide a novel therapeutic approach to CNS injury by modulating Syt4 function.