bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice of Tocilisumab Application in Patients with COVID-19 (Results of Retrospective Monitoring)
Authors: Гавриленко Л.Н. , Кожанова И.Н. , Романова И.С. , Давидовская Е.И. , Литвинова Т.И. , Дедюшко Г.В. , Павлющенко О.А. , Бавыкина Н.П. , Кенденков О.И. , Садовская О.Г. , Тимофеева М.А. , Шаранова О.А. , Чайковская Г.В. , Якушева Т.Н. 
Published: February 2022

Тоцилизумаб - рекомбинантное гуманизированное моноклональное антитело к человеческому рецептору интерлейкина-6 (ИЛ-6) из подкласса иммуноглобулинов IgG1. Цель. Установить обоснованность применения тоцилизумаба, эффективность, переносимость и безопасность режима дозирования тоцилизумаба при включении его в схему лечения пациентов с коронавирусной инфекцией. Материалы и методы. Проведено ретроспективное исследование методом ретроспективного мониторинга с использованием данных медицинских историй болезни стационарного пациента за период декабрь 2020 г. - январь 2021 г. Предметом анализа являлись сведения о количестве тоцилизумаба, реализованного в стационаре, по данным аптеки стационара; клиническая характеристика пациентов, которым тоцилизумаб назначался; особенности использования тоцилизумаба (дозы, кратность, время введения); исходы заболевания у пациентов. В исследовании принимали участие врачи - клинические фармакологи учреждений здравоохранения г. Минска, Гомельской, Гродненской и Брестской областей, ГУ «РНПЦ пульмонологии и фтизиатрии». Выводы. Назначение тоцилизумаба было обосновано и проводилось в соответствии с показаниями, отраженными в приказе Министерства здравоохранения Республики Беларусь от 11.11.2020 № 1195 «Временные рекомендации об организации оказания помощи пациентам с инфекцией COVID-19».
Tocilizumab is a recombinant humanized monoclonal antibody to the human interleukin-6 (IL-6) receptor from the IgG1 immunoglobulin subclass. Purpose. To establish the validity of the use of tocilizumab, as well as the efficacy, tolerability and safety of the dosing regimen of tocilizumab when included in the treatment regimen for patients with coronavirus infection. Materials and methods. A retrospective study was carried out using the method of retrospective monitoring using data from medical histories of an inpatient for the period December 2020 - January 2021. The subject of the analysis was information on the amount of tocilizumab realaized in the hospital according to the data of the hospital pharmacy; clinical characteristics of patients to whom tocilizumab was prescribed; features of the use of tocilizumab (dose, frequency, time of administration); disease outcomes in patients. Clinical pharmacologists take part from clinics in Minsk, Gomel, Grodno and Brest regions, the Republican Scientific and Practical Center for Pulmonology and Phthisiology. Conclusions. The appointment of tocilizumab was justified and carried out in accordance with the indications reflected in the Order of the Ministry of Health of the Republic of Belarus dated 11.11.2020 No. 1195 "Temporary recommendations on the organization of care for patients with COVID-19 infection".
Modern View of Clinical and Pharmacological Approaches in the Treatment of Anosmia
Authors: Максименя Г.Г. 
Published: February 2022

Статья посвящена обсуждению причин появления аносмии при COVID-19, выявлению данной патологии и оценке имеющихся способов лечения. Материал содержит рекомендации применения натуральных растительных лекарственных средств, синтетических препаратов, витаминов и микроэлементов в процессе лечения аносмии в зависимости от вида данной патологии. Материал изложен с акцентом на компетенциях и практических навыках врача общей практики.
The article is devoted to the discussion of the causes of the manifestation of anosmia in COVID-19, the identification of this pathology and the assessment of the available treatment methods. The material contains recommendations for the use of natural herbal medicines, synthetic drugs, vitamins and trace elements in the treatment of anosmia, depending on the type of this pathology. The material is presented with an emphasis on the competence and practical skills of a general practitioner.
Periodic Hypobaric Adaptation in Patients with Bronchial Asthma Suffering after Pneumonia COVID-19 in Outpatient Rehabilitation
Authors: Оленская Т.Л. , Ковалева Л.Ф. , Николаева А.Г. , Рыковский Д.М. , Юхно Ю.С. , Азарёнок М.К. 
Published: February 2022

В работе представлены результаты исследования пациентов с бронхиальной астмой после перенесенной пневмонии, ассоциированной с инфекцией COVID-19, до и после однокомпонентной программы медицинской реабилитации адаптированного курса периодической гипобарической барокамерной адаптации. С учетом полученных результатов, показана рациональность применения для данной категории пациентов предложенного метода на амбулаторном этапе медицинской реабилитации.
This article presents the results of a study of patients with bronchial asthma suffering after pneumonia associated with COVID-19 infection after a one-component medical rehabilitation program of an adapted course of periodic altitude chamber adaptation. Taking into account the obtained results, the rational use of the proposed method for this category of patients at the outpatient stage of medical rehabilitation is shown.
Prevention of the Development of Fall Syndrome after COVID-19 Pneumonia in Elderly People at the Outpatient Stage of Medical Rehabilitation
Authors: Оленская Т.Л. , Николаева А.Г. , Азарёнок М.К. , Мартынова Е.В. , Орехва О.И. , Юхно Ю.С. , Апенко Е.В. 
Published: February 2022

Появление и распространение инфекции COVID-19 поставило перед специалистами здравоохранения задачи, связанные с созданием программ восстановления и реабилитации для пациентов разных возрастных групп после перенесенных пневмоний. В работе представлены результаты обследования лиц старшего возраста после перенесенной пневмонии, ассоциированной с инфекцией COVID-19, до и после одно- и двухкомпонентных программ медицинской реабилитации. Показана рациональность применения для пациентов пожилого возраста на амбулаторном и домашнем этапах медицинской реабилитации предложенной методики гипобарической барокамерной адаптации, эффективность которой увеличивалась в сочетании с назначением цитофлавина.
The emergence and spread of COVID-19 infection has set health professionals the task of providing recovery and rehabilitation programs after pneumonia for patients of different age groups. The paper presents the results of a survey of older people after pneumonia associated with COVID-19 infection before and after one-and two-component medical rehabilitation programs. The rationality of using the proposed hypobaric hyperbaric chamber adaptation technique for elderly patients at the outpatient and home stages of medical rehabilitation, the effectiveness of which increased in combination with the appointment of cytoflavin, is shown.
Transient Ischemic Attack as a Predictor Ischemic Stroke
Authors: Михалюк Р.А. 
Published: February 2022

Статья посвящена транзиторной ишемической атаке как предиктору ишемического инсульта и его фактору риска, значительно увеличивающему вероятность его развития, а также являющейся биомаркером неблагоприятного течения сердечно-сосудистых заболеваний. Рассмотрены причины, классификация, клинические проявления, вопросы диагностики и основные направления профилактической терапии. Показана значимость подходов ранней диагностики, уточнения причин и механизмов декомпенсации мозгового кровообращения, что определяет обоснованное, целенаправленное лечение транзиторной ишемической атаки как важнейшее направление профилактики инсультов.
The article is devoted to transient ischemic attack being a predictor of ischemic stroke and its risk factor that significantly increases its probability. Transient ischemic attack is also a biomarker of an adverse course of cardiovascular diseases. The causes, classification, clinical manifestations, diagnostic issues and the main directions of preventive therapy are examined. The article focuses on the importance of early diagnosis and clarification of the causes and mechanisms of cerebral circulation decompensation, which determines reasonable, targeted treatment of transient ischemic attack as the most important area of stroke prevention.
Underwater acoustic communication using orthogonal signal division multiplexing with windowing
Authors: Tabata Yushi , Ebihara Tadashi , Ogasawara Hanako , Wakatsuki Naoto , Zempo Keiichi , Mizutani Koichi 
Published: February 2022

Abstract
Underwater acoustic (UWA) communication is an essential technology that supports underwater surveys by transmitting images and movies wirelessly. However, UWA communication is still challenging due to the large delay and Doppler spreads in UWA channels. Doppler-resilient orthogonal signal division multiplexing (D-OSDM) under water has been found effective in such channels, but Doppler modeling errors prevent further improvement in communication quality. In this paper, we clarify the effect of Doppler modeling errors on the communication quality of D-OSDM and propose the use of a window function in D-OSDM to address the issues that such errors raise. We also evaluate the communication quality of D-OSDM using the window function through simulations and experiments. The experimental results show a 56% increase in the number of error-free data blocks, indicating that windowing can improve communication quality.
Preparation of moth-eye structures on curved surfaces by nanoimprinting using anodic porous alumina molds
Authors: Yanagishita Takashi , Omata Manami , Masuda Hideki 
Published: February 2022

Abstract
Al substrates with smooth curved surfaces were fabricated by peeling off Al foil sputtered on the surface of concaved substrates. Anodic porous alumina with tapered pores on the curved surface was obtained by repeated anodization and etching of the obtained Al substrate. The moth-eye structure was formed on the curved surface by nanoimprinting using the anodic porous alumina as a mold. From the reflectance measurement, it was shown that the reflection of the incident light was suppressed on the curved surface where the moth-eye structure was formed. This process can be used to fabricate moth-eye structures on the surface of substrates of various shapes by changing the substrate used for sputtering and is expected to expand the range of applications for moth-eye structures.
GaN MMICs on a diamond heat spreader with through-substrate vias fabricated by deep dry etching process
Authors: Minoura Yuichi , Ohki Toshihiro , Okamoto Naoya , Sato Masaru , Ozaki Shiro , Yamada Atsushi , Kotani Junji 
Published: February 2022

Abstract
GaN monolithic microwave integrated circuits (MMICs) on a diamond heat spreader were successfully fabricated and demonstrated. The diamond was bonded to the back-side surface of the GaN on SiC devices by atomic diffusion bonding. In addition, through-substrate vias (TSVs) of diamond and SiC were fabricated using a deep dry etching process. This study marks the first development of GaN MMIC on diamond with TSVs fabricated using diamond etching. From the large-signal measurement of GaN MMICs at 7 GHz, the output power of the device with diamond during continuous wave operation was improved by 11% compared to that of without diamond.
Trends in the development of book printing and book distribution in the world's leading countries through the lens of reading problems
Authors: Tatarinova Larуsa 
Published: February 2022

The features of book distribution systems in different countries of the world are investigated. The role of book clubs and book chains in the way of a book to its reader is revealed. The leading role of the state support for book publishing is outlined. Factors of state support for book publishing and book distribution, such as creating reading development programs, facilitating the opening of new bookstores, organizing book fairs, exhibitions, festivals and other events to support the book, establishing literary prizes and competitions, replenishing library funds, protecting copyright, have been identified. Possibilities of introduction of experience of leading countries of the world (in particular Canada) in support of book publishing and book distribution industry, such as granting of preferential credits, influence on book pricing, introduction of a "fixed" price during book realization, are investigated.
The media habits of the inhabitants of different countries of the world have been researched, it has been found out how much time a person spends watching TV programs, listening to music on the radio, reading. Although in the modern world, residents are spending less and less time on the book, preferring other types of entertainment and leisure, the books are no less printable, book publishing remains a large business, valued at $ 151 billion and generating more than cinema, magazines, video games and music. In an effort to survive, book publishers are united in media conglomerates, most of their profits are from book sales.
The readers' preferences been investigated. The competitiveness of paper and e-books has been investigated too. The advantages of paper books over e-books have been proved. Research shows that e-books are growing in popularity, but growth has slowed slightly since 2016. It is emphasized that paper books are the basis of reader's attention and demand.
Peran Kompetensi Sebagai Variabel Intervening Hubungan Pembelajaran Organisasi & Motivasi Spiritual Terhadap Kinerja Dosen dan Karyawan (Studi Pada IAIN Pekalongan)
Authors: Setiawan Singgih , Nafilah Nafilah 
Published: February 2022

Penelitian ini bertujuan untuk menguji pengaruh Pembelajaran Organisasi dan Motivasi Spiritual Terhadap Kinerja Dosen dan Karyawan. Disamping itu, penelitian ini juga bertujuan untuk menguji peran Kompetensi sebagai variabel intervening. Untuk menguji variabel tersebut, peneliti memilih Dosen dan Karyawan di IAIN Pekalongan sebagai objek penelitian.
Penelitian dilakukan dengan metode menyebarkan kuisioner kepada 100 Dosen dan Karyawan di IAIN Pekalongan. Pengambilan Sampel penelitian menggunakan teknik Random Sampling..
Hasil Penelitian menunjukkan bahwa Pembelajaran Organisasi dan Motivasi Spiritual berpengaruh positif signifikan terhadap Kinerja Dosen dan Karyawan pada IAIN Pekalongan. Sedangkan Kompetensi sebagai variabel intervening memperkuat pengaruh Pembelajaran Organisasi dan Motivasi Spiritual terhadap Kinerja Dosen dan Karyawan pada Institut Agama Islam Negeri (IAIN) Pekalongan.
Pengaruh Pemberian Insentif, Peningkatan Disiplin, dan Pemberian Motivasi terhadap Hasil Belajar Mahasiswa Politeknik Ganesha Medan
Authors: Hariyanti Irma , Epi Yus 
Published: February 2022

Penelitian ini ini bertujuan untuk meningkatkan hasil belajar mahasiswa Politeknik Ganesha Medan dengan cara memberikan insentif, peningkatan displin dan pemberian motivasi kepada mahasiswa Politeknik Ganesha Medan. Metode pengambilan sampel pada penelitian ini adalah metode random sampling sebanyak 76 orang mahasiswa. Data yang diperoleh terlebih dahulu akan diuji dengan uji validitas, reliabilitas, normalitas, multikolinearitas dan heterokedastisitas. Teknik analisis data untuk menganalisis hipotesis dalam penelitian ini adalah analisis regresi berganda (Multiple Regression Analysis) untuk menguji variabel bebas (pemberian insentif, disiplin dan motivasi) terhadap variabel terikat (hasil belajar mahasiswa), Uji F dan Uji t.
Hasil analisis regresi menunjukkan bahwa dari ketiga variabel independen yang dimasukkan kedalam model regresi (pemberian insentif, peningkatan disiplin, dan pemberian motivasi) bahwa insentif secara langsung berpengaruh positif dan signifikan terhadap hasil belajar dengan nilai t hitung > t tabel (2,201 > 1, 996) nilai sig.t < dari α 5 % (0,031 < 0,05). Peningkatan disiplin secara langsung berpengaruh positif tetapi tidak signifikan terhadap hasil belajar dengan nilai t hitung < t tabel (1,367 < 1, 996) nilai sig.t > dari α 5 % (0,176 > 0,05). Pemberian motivasi secara langsung berpengaruh positif dan signifikan terhadap hasil belajar dengan nilai t hitung > t tabel (3,246 > 1,996) nilai sig.t < dari α 5 % (0,02 < 0,05). Pemberian insentif, peningkatan disiplin dan pemberian motivasi secara simultan berpengaruh positif dan signifikan terhadap hasil belajar dengan nilai F hitung > F tabel (16,236 > 2,730) nilai sig. F < dari 5 % (0,000 < 0,05)
THE EFFECT OF LEVERAGE ON HEDGING THROUGH PROFITABILITY MEDIATION VARIABLES IN COMPANIES LISTED IN JAKARTA ISLAMIC INDEX (JII) IN 2015-2020
Authors: Satria Chandra , Nofiansyah Doly , Rizvi M Fazal 
Published: February 2022

This research is to analyze the effect of leverage on hedging with profitability as a mediating variable in companies listed on the Jakarta Islamic Index (JII) in 2015-2020. This research methodology uses quantitative methods with instrument testing using SEM Pls using SmartPLS software. The results show that Leverage has a significant positive effect on Profitability, Leverage has no effect on Hedging, Profitability has a significant positive effect on Hedging, Leverage has an effect on Hedging through Profitability. The limitation in the research is only the object in this study is still limited to companies listed on the Jakarta Islamic Index (JII). The research period carried out in this study was only 5 years, namely in 2015-2020, it is hoped that further research can use a longer period so that the level of research accuracy is higher and can add a variable level of currency prices to see the wider influence of leverage on the hedging of a company when viewed from investors who come from outside
PENGARUH CITRA MEREK, KUALITAS PELAYANAN, DAN PERSEPSI HARGA TERHADAP NIAT BELI ULANG
Authors: Sandy Niken Faradilla , Aquinia Ajeng 
Published: February 2022

Penelitian ini bertujuan untuk menganalisis pengaruh citra merek, kualitas pelayanan, persepsi harga terhadap niat beli ulang. Penelitian ini dilakukan di apotek K24 cabang Gubug. Populasi dalam penelitian ini adalah pelanggan apotek K24 cabang Gubug. Sampel dalam penelitian ini adalah 100 konsumen dengan menggunakan metode purposive sampling. Teknik analisis data yang digunakan meliputi uji validitas dengan KMO (Kaiser Mayer Olkin) dan loading factor (matriks komponen), uji reliabilitas dengan Cronbach alpha dan analisis regresi berganda. Hasil penelitian ini menunjukkan bahwa citra merek berpengaruh positif dan signifikan terhadap niat beli ulang, kualitas layanan tidak berpengaruh terhadap niat beli ulang, dan persepsi harga berpengaruh positif dan signifikan terhadap niat beli ulang.
kata kunci :Citra Merek, Kualitas Pelayanan, dan Persepsi Harga, dan Niat Beli Ulang.
The Relationship between Age of Menarche and Body Mass Index (BMI) with Endometriosis Incidence at Dr. Mohammad Hoesin Palembang Period 2018 – 2020
Authors: Usman Fatimah , Ghina Reza S  , Eka Handayani  
Published: February 2022

Background. Endometriosis is the presence of endometrial glands and stroma outside the uterus. This study aims to analyze the relationship between age of menarche and body mass index (BMI) with the incidence of endometriosis.
Methods. This study is an analytical observational study with a cross-sectional approach. The samples taken in this study were post-operative patients with gynecological disorders at Dr. Mohammad Hoesin General Hospital Palembang. The sample taken in this study was 62 respondents during the period 2018-2020 with a simple random sampling technique based on inclusion criteria. The research data was processed and analyzed by univariate and bivariate with Chi-square test using SPSS application.
Results. Most of the respondents with endometriosis experienced at the age of menarche <12 years (91.3%) and had a non-obese BMI (73.3%). There was a significant relationship between the age of menarche and the endometriosis incidence (p=0.039). There was no statistically significant relationship between body mass index (BMI) and the endometriosis incidence (p=1,043).
Conclusion. Early menarche can increase the risk of endometriosis. The majority of women with endometriosis in this study had a BMI in the non-obese category (BMI <25).
Oscillatory Reconnection of a 2D X-point in a Hot Coronal Plasma
Authors: Karampelas Konstantinos , McLaughlin James A. , Botha Gert J. J. , Régnier Stéphane 
Published: February 2022

Abstract
Oscillatory reconnection (a relaxation mechanism with periodic changes in connectivity) has been proposed as a potential physical mechanism underpinning several periodic phenomena in the solar atmosphere, including, but not limited to, quasi-periodic pulsations (QPPs). Despite its importance, however, the mechanism has never been studied within a hot, coronal plasma. We investigate oscillatory reconnection in a one million Kelvin plasma by solving the fully-compressive, resistive MHD equations for a 2D magnetic X-point under coronal conditions using the PLUTO code. We report on the resulting oscillatory reconnection including its periodicity and decay rate. We observe a more complicated oscillating profile for the current density compared to that found for a cold plasma, due to mode-conversion at the equipartition layer. We also consider, for the first time, the effect of adding anisotropic thermal conduction to the oscillatory reconnection mechanism, and we find this simplifies the spectrum of the oscillation profile and increases the decay rate. Crucially, the addition of thermal conduction does not prevent the oscillatory reconnection mechanism from manifesting. Finally, we reveal a relationship between the equilibrium magnetic field strength, decay rate, and period of oscillatory reconnection, which opens the tantalising possibility of utilizing oscillatory reconnection as a seismological tool.
Comparison of the Hall Magnetohydrodynamics and Magnetohydrodynamics Evolution of a Flaring Solar Active Region
Authors: Bora K. , Bhattacharyya R. , Prasad Avijeet , Joshi Bhuwan , Hu Qiang 
Published: February 2022

Abstract
This work analyzes the Hall magnetohydrodynamics (HMHD) and magnetohydrodynamics (MHD) numerical simulations of a flaring solar active region as a test bed while idealizing the coronal Alfvén speed to be less by two orders of magnitude. HMHD supports faster magnetic reconnection and shows richer complexity in magnetic field line evolution compared to the MHD. The magnetic reconnections triggering the flare are explored by numerical simulations augmented with relevant multiwavelength observations. The initial coronal magnetic field is constructed by non-force-free extrapolation of photospheric vector magnetic field. Magnetic structure involved in the flare is identified to be a flux rope, with its overlying magnetic field lines constituting the quasi-separatrix layers (QSLs) along with a three-dimensional null point and a null line. Compared to the MHD simulation, the HMHD simulation shows a higher and faster ascent of the rope together with the overlying field lines, which further reconnect at the QSL located higher up in the corona. The footpoints of the field lines match better with the observations for the HMHD case, with the central part of the flare ribbon located at the chromosphere. Additionally, field lines are found to rotate in a circular pattern in the HMHD, whereas no such rotation is seen in the MHD results. Interestingly, plasma is also observed to be rotating in a cospatial chromospheric region, which makes the HMHD simulation more credible. Based on the aforementioned agreements, HMHD simulation is found to agree better with observations and thus opens up a novel avenue to explore.