bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tartary buckwheat FtMYB30 transcription factor improves the salt/drought tolerance of transgenic Arabidopsis in an ABA‐dependent manner
Authors: Wang Shuang , Wu Huala , Cao Xinxian , Fan Wenjing , Li Chenglei , Zhao Haixia , Wu Qi 
Published: September 2022

AbstractDrought and high salinity affect plant growth, development, yield, and quality. MYB transcription factors (TFs) in plants play an indispensable regulatory role in resisting adverse stress. In this study, screening and functional validation of the TF FtMYB30, which can respond extensively to abiotic stress and abscisic acid (ABA), was achieved in Tartary buckwheat. FtMYB30, one of the SG22 (sub‐group 22) family of R2R3‐MYB TFs, localized in the nucleus and had transcriptional activation activity. Under drought and salt stress, FtMYB30 overexpression reduced the oxidative damage in transgenic plants by increasing the activity of proline content and antioxidant enzymes and significantly upregulate the expression of RD29A, RD29B, and Cu/ZnSOD, thereby enhancing drought/salt tolerance in transgenic Arabidopsis. Additionally, overexpression of FtMYB30 can reduce the sensitivity of transgenic plants to ABA. Moreover, AtRCAR1/2/3 and AtMPK6 directly interact with the FtMYB30 TF, possibly through the crosstalk between MAPKs (mitogen‐activated protein kinases) and the ABA signaling pathway. Taken together, these results suggest that FtMYB30, as a positive regulator, mediates plant tolerance to salt and drought through an ABA‐dependent signaling pathway.
Seismic expression and stratigraphic preservation of a coastal plain fluvial channel belt and floodplain channels on the Gulf of Mexico inner continental shelf
Authors: Speed Cole M. , Swartz John M. , Gulick Sean P. S. , Goff John A. 
Published: September 2022

AbstractSubsurface fluvial deposits in coastline‐proximal settings record the spatiotemporal evolution of the coastal landscape and may be viable repositories of sediment for future coastal restoration projects. However, quantitative linkages between the geomorphic form and stratigraphic expression of coastal plain fluvial elements remain lacking, complicating coastal stratigraphic interpretations and subsurface resource assessment. This study explores the expression and preservation of fluvial coastal plain geomorphic features through outcrop‐scale seismic stratigraphic analysis of ultra‐high‐resolution chirp acoustic reflection data from the north‐western Gulf of Mexico inner continental shelf, offshore the Brazos River, Texas, USA. The chirp data exhibit decimetre‐scale vertical resolution within the upper 35 m of the shelf, evincing the preservation of two distinct types of coexisting fluvial channel‐forms: Type 1, a 1 km wide and 9 m deep single‐storey channel belt filled with sand‐rich lateral accretion deposits and channel fills; and Type 2, numerous 10 to 800 m wide and 1 to 20 m deep incisional floodplain channels filled with extensive drapes of overbank‐derived sediments. The chirp data resolve fluvial geomorphic elements including lateral accretion surfaces, levées, floodplain deposits and abandoned channel fills. Rollover of lateral accretion surfaces, widespread draping of seismic reflectors within channel fills, and quantitative comparison between the interpreted stratigraphic forms and analogous features on the nearby Texas Coastal Plain suggest near‐complete stratigraphic preservation of the geomorphic form of both channel belt and floodplain channel elements. Rapid aggradation of the coastal plain by the Brazos River in this region during the Holocene transgression is hypothesized as a mechanism for the high degree of preservation achieved. This study proposes the first recognition criteria for the seismic stratigraphic expression of coastal floodplain channels and provides direct linkages between the geomorphic and stratigraphic expression of a coastal plain fluvial landscape, promoting improved coastal stratigraphic interpretations and assessment of subsurface lithofacies distributions.
A note on Etchemendy's and Prawitz's reduction principles for the Tarskian and model‐theoretic concept of consequence
Authors: Piccolomini d'Aragona Antonio 
Published: September 2022

AbstractOne of Etchemendy's arguments against the Tarskian and model‐theoretic notion of logical truth is based on a reduction principle according to which a universally quantified sentence is true if, and only if, all of its instances are logically true. The reduction of logical truth to mere truth reveals that the concept of validity at play in Tarski and in model‐theory relies upon extra‐logical assumptions. A similar reduction had already been put forward by Prawitz, although not with focus on extra‐logical assumptions. Prawitz's reduction concerns rather the possibility of understanding the Tarskian and model‐theoretic approach as implying any epistemic modality. We take into account a possible strategy that an advocate of Tarski and model‐theory may use against Etchemendy's objection, and argue that this strategy fails with respect to Prawitz's criticism. This permits us to shed light upon a difference between Prawitz's and Etchemendy's standpoints: while Etchemendy's reduction shows that the Tarskian and model‐theoretic notion of logical truth cannot be understood as an adequate formal counterpart of truth‐preservation solely by virtue of logical form, Prawitz's reduction insists on the fact that truth‐preservation solely by virtue of logical form is insufficient for epistemic modality to obtain.
Blood transfusion is associated with increased mortality for neonates with congenital diaphragmatic hernia on extracorporeal membrane oxygenation support
Authors: Yang Yu , Gowda Sharada H. , Hagan Joseph L. , Hensch Lisa , Teruya Jun , Fernandes Caraciolo J. , Hui Shiu‐Ki R. 
Published: September 2022

AbstractBackground and ObjectivesBlood transfusion is frequently needed to maintain adequate haemostasis and improve oxygenation for patients treated with extracorporeal membrane oxygenation (ECMO). It is more so for neonates with immature coagulation systems who require surgical intervention such as congenital diaphragmatic hernia (CDH) repair. There is growing evidence suggesting an association between blood transfusions and increased mortality. The aim of this study is to evaluate the association of blood transfusions during the peri‐operative period of CDH repair, among other clinical parameters, with mortality in neonates undergoing on‐ECMO CDH repair.Materials and MethodsWe performed a single centre retrospective chart review of all neonates with CDH undergoing on‐ECMO surgical repair from January 2010 to December 2020. Logistic regression was used to investigate associations with survival status.ResultsSixty‐two patients met the inclusion criteria. Platelet transfusions (odds ratio [OR] 1.42, 95% confidence interval [CI]: 1.06–1.90) in the post‐operative period and ECMO duration (OR 1.17, 95% CI: 1.05–1.30) were associated with increased mortality. Major bleeding complications had the strongest association with mortality (OR 10.98, 95% CI: 3.27–36.91). Gestational age, birth weight, Apgar scores, sex, blood type, right versus left CDH, venovenous versus venoarterial ECMO and duration of ECMO before CDH repair and circuit change after adjusting for ECMO duration were not significantly associated with survival.ConclusionPlatelet transfusion in the post‐operative period and major bleeding are associated with increased mortality in CDH neonates with surgical repair. The data suggest a need to develop robust plans for monitoring and preventing coagulation aberrancies during neonatal ECMO support.
Reconstruction of the flexor carpi ulnaris tendon with a fascia lata autograft in two dogs with carpal hyperextension
Authors: Tani Yuichiro 
Published: September 2022

AbstractObjectiveTo describe the outcome of two dogs treated with fascia lata autografts to repair carpal hyperextension caused by flexor carpi ulnaris (FCU) tendon injury.AnimalsTwo dogs with traumatic carpal hyperextension.Study designCase report.MethodsRadiographic abnormalities were detected in the antebrachiocarpal joint of each dog. Damage to the FCU tendon were located at the ulnar head on ultrasonographic and intraoperative examinations. Each injured tendon was reconstructed with a fascia lata graft. The radius and metacarpal bones were immobilized by a type I external skeletal fixation for 6 weeks.ResultsNo difference was detected between the operated and contralateral limbs on postoperative examination, including range of motion, and angles of the carpus during standing or extension stress. No recurrence of carpal hyperextension was observed over 36 months after surgery.ConclusionCarpal hyperextension was successfully treated by primary repair of the damaged area and reinforcement with fascia lata and maintained long‐term joint mobility in two dogs.
Phantoms for ultrasound-guided vascular access cannulation training: a narrative review
Authors: García-Carpintero Eva , Naredo Esperanza , Vélez-Vélez Esperanza , Fuensalida Gema , Ortiz-Miluy Gloria , Gómez-Moreno Cristina 
Published: September 2022

The objective of this paper is to review and compare the different commercial and homemade models of ultrasound-guided vascular cannulation phantoms, as well as the methods used for the elaboration of the latter. There are a variety of simulators for ultrasound-guided puncture techniques, from simple homemade phantoms to the most sophisticated and expensive virtual reality simulators. Commercial-grade ultrasound phantoms are expensive and although they are reusable, their cost can be a barrier to simulation-based training. Homemade phantoms are a cost-effective, highly useful tool for teaching vascular access using ultrasound. For the elaboration of the homemade ones, different substances and elements are usually used to produce varied echogenicities and geometries. Specifically, animal-based ones provide more realistic tissue feedback and have a back-ground echogenicity that is closer to that of human tissue. A powerful alternative is the use of poly vinyl alcohol or modified mixtures of this material, which would be better suited to cannulation simulation with high functional fidelity.
Supplemental Material: Late Paleozoic cratonal sink: Distally sourced sediment filled the Anadarko Basin (USA) from multiple source regions
Authors: Kushner Baylee , al. et , Soreghan M.J. 
Published: September 2022

<p>Table S1: U-Pb geochronologic data and acquisition parameters for detrital zircon samples presented in this study. Table S2: Raw point count data for samples from this study used in the modal mineralogy analysis. Table S3: Metadata for detrital zircon datasets from published studies used in this study. </p>
Association between the Dietary Inflammatory Index with gallstone disease: finding from Dena PERSIAN cohort
Authors: Sadri Zeinab , Harouni Javad , Vahid Farhad , Khosravani Zohreh , Najafi Fereshteh 
Published: September 2022

ObjectiveThe Dietary Inflammatory Index (DII) is a documented nutritional tool for assessing diet-induced inflammation that has been linked to various diseases/outcomes. The association between DII and gallstone disease (GSD) is yet to be explored. The objective of this study was to examine the association between DII and GSD.DesignThis cross-sectional study was conducted using the baseline phase data of the Dena PERSIAN cohort. The analysed data included demographic information, lifestyle variables, body mass index, diabetes and fatty liver history, and laboratory test results. The 113-item Food Frequency Questionnaire was used to estimate the dietary intake of participants and quantify the inflammatory potential of the individual’s diet. DII score was analysed as a continuous and quartiles variables. Univariable and multivariate logistic regressions were used to investigate the relationship between GSD and DII scores .ResultsOut of 3626 individuals entering the study, 173 (4.77%) had GSD. The median DII was −0.08 (IQR=0.18). In the unadjusted model, the odds of having GSD were significantly higher in the first and second quartiles of DII (anti-inflammatory diet) than in higher quartiles (proinflammatory diet). In the adjusted model, the odds of having GSD in the third and fourth quartiles of DII scores compared with the first quartile were OR=0.59 (95% CI 0.36 to 0.95) and OR 0.51 (95% CI 0.30 to 0.84), respectively.ConclusionThe results of this study suggest that a proinflammatory diet is associated with a reduced chance of GSD. However, longitudinal studies are needed to examine the causal association.
Safety and impact of eculizumab withdrawal in patients with atypical haemolytic uraemic syndrome: protocol for a multicentre, open-label, prospective, single-arm study
Authors: Dunn Sarah , Brocklebank Victoria , Bryant Andrew , Carnell Sonya , Chadwick Thomas J , Johnson Sally , Kavanagh David , Lecouturier Jan , Malina Michal , Moloney Eoin , Oluboyede Yemi , Weetman Christopher , Wong Edwin Kwan Soon , Woodward Len , Sheerin Neil 
Published: September 2022

IntroductionAtypical haemolytic uraemic syndrome (aHUS) is a rare, life-threatening disease caused by excessive activation of part of the immune system called complement. Eculizumab is an effective treatment, controlling aHUS in 90% of patients. Due to the risk of relapse, lifelong treatment is currently recommended. Eculizumab treatment is not without problems, foremost being the risk of severe meningococcal infection, the burden of biweekly intravenous injections and the high cost.This paper describes the design of the Stopping Eculizumab Treatment Safely in aHUS trial that aims to establish whether a safety monitoring protocol, including the reintroduction of eculizumab for those who relapse, could be a safe, alternative treatment strategy for patients with aHUS.Methods and analysisThis is a multicentre, non-randomised, open-label study of eculizumab withdrawal with continuous monitoring of thrombotic microangiopathy-related serious adverse events using the Bayes factor single-arm design. 30 patients will be recruited to withdraw from eculizumab and have regular blood and urine tests for 24 months, to monitor for disease activity. If relapse occurs, treatment will be restarted within 24 hours of presentation. 20 patients will remain on treatment and complete health economic questionnaires only. An embedded qualitative study will explore the views of participants.Ethics and disseminationA favourable ethical opinion and approval was obtained from the North East-Tyne & Wear South Research Ethics Committee. Outcomes will be disseminated via peer-reviewed articles and conference presentations.Trial registration numberEudraCT number: 2017-003916-37 and ISRCTN number:ISRCTN17503205.
Associations of childhood maltreatment with hypertension in South African women: a cross-sectional study
Authors: Nguyen Kim Anh , Kengne Andre Pascal , Abrahams Naeemah , Jewkes Rachel , Mhlongo Shibe , Peer Nasheeta 
Published: September 2022

ObjectivesTo examine the associations of childhood maltreatment (CM) with hypertension, and the mediating effects of hypertension risk factors on the associations in South African women, using baseline data of the Rape Impact Cohort Evaluation longitudinal study.DesignCross-sectionalSetting and participantsSelf-reported data on CM exposure and its severity in 18–40-year-old women living in KwaZulu-Natal province were assessed. Logistic regression models, adjusted for traditional hypertension risk factors, rape exposure, HIV-infection, other traumatic exposures, depression scores and acute stress reactions (ASR) scores were used to examine the CM–hypertension associations.ResultsAmong 1797 women, 220 (12.2%) had hypertension; CM prevalence was higher in women with hypertension than without hypertension overall (70.9% vs 57.2%) and for each abuse type: sexual abuse (20.9% vs 12.4%), physical abuse (51.8% vs 41.5%), emotional abuse (40% vs 27.6%) and parental neglect (35% vs 25.7%). Exposures to 1–2 types and 3–4 types of CM were 46.4% and 24.5%, respectively, in women with hypertension, and lower in women without (42.9% and 14.3%, respectively). Exposures to any CM (adjusted OR: 1.62; 95% CI: 1.19 to 2.25), sexual abuse (1.64; 95% CI: 1.12 to 2.37), emotional abuse (1.57; 95% CI: 1.16 to 2.13), physical abuse (1.43; 95% CI: 1.07 to 1.92) and parental neglect (1.37; 95% CI: 1.00 to 1.86) were associated with hypertension. Exposures to an increasing number of abuse types and cumulative severity of CM overall (1.13; 95% CI: 1.05 to 1.21) and for each CM type were associated with increased odds of hypertension. Alcohol use, other trauma experienced, depression and ASR partially mediated these associations.ConclusionCM was associated with hypertension; the effects were greater with multiple abuse types and severe abuse, and were partially mediated by alcohol use, depression, ASR and other traumatic exposures. While CM must be prevented, effective mental health interventions to curb the uptake of unhealthy behaviours and the development of hypertension in women exposed to CM are key.
Protocol describing a systematic review and mixed methods consensus process to define the deteriorated ward patient
Authors: Malycha James , Andersen Chris , Redfern Oliver C , Peake Sandra , Subbe Christian , Dykes Lukah , Phillips Adam , Ludbrook Guy , Young Duncan , Watkinson Peter J , Flabouris Arthas , Jones Daryl 
Published: September 2022

IntroductionMost patients admitted to hospital recover with treatments that can be administered on the general ward. A small but important group deteriorate however and require augmented organ support in areas with increased nursing to patient ratios. In observational studies evaluating this cohort, proxy outcomes such as unplanned intensive care unit admission, cardiac arrest and death are used. These outcome measures introduce subjectivity and variability, which in turn hinders the development and accuracy of the increasing numbers of electronic medical record (EMR) linked digital tools designed to predict clinical deterioration. Here, we describe a protocol for developing a new outcome measure using mixed methods to address these limitations.Methods and analysisWe will undertake firstly, a systematic literature review to identify existing generic, syndrome-specific and organ-specific definitions for clinically deteriorated, hospitalised adult patients. Secondly, an international modified Delphi study to generate a short list of candidate definitions. Thirdly, a nominal group technique (NGT) (using a trained facilitator) will take a diverse group of stakeholders through a structured process to generate a consensus definition. The NGT process will be informed by the data generated from the first two stages. The definition(s) for the deteriorated ward patient will be readily extractable from the EMR.Ethics and disseminationThis study has ethics approval (reference 16399) from the Central Adelaide Local Health Network Human Research Ethics Committee. Results generated from this study will be disseminated through publication and presentation at national and international scientific meetings.
Active monitoring versus immediate abduction as treatment of stable developmental dysplasia of the hip: a systematic review of the literature
Authors: Paulussen Evy M B , Mulder Frederike E C M , Mathijssen Nina M C , Witlox M Adhiambo 
Published: September 2022

ObjectivesThis systematic review aims to compare the effects of active monitoring and abduction treatment on the Graf alpha angle, Acetabular Index (AI) and femoral head coverage in infants with stable developmental dysplasia of the hip (DDH).DesignSystematic review reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesA search of the PubMed, Embase, Cochrane and Web of Science databases was performed in January 2020 and updated in January 2021.Eligibility criteria(Non-)randomised studies comparing active monitoring with abduction treatment in infants younger than 4 months with stable DDH were included.Data extraction and synthesisAll eligible articles were methodologically assessed using the Cochrane risk of bias tools. Data were extracted by summarising the study characteristics and results.ResultsOf the six included studies, two randomised studies were of low risk and two of some concerns. Two non-randomised studies were of serious risk. In total, 544 dysplastic hips (439 infants) were investigated, of which 307 were observed and 237 were treated. Two studies reported a faster improvement of the alpha angle and average acetabular coverage in treated hips at 3 months. No differences in AI between the treatment and observation group after 3 months were reported. In total, 38 infants (12%) in the observation group switched to the treatment group. At the final radiograph, 21 observed hips and 32 treated hips were dysplastic.ConclusionsThere were no differences in AI between the treatment and observation group after 3 months in infants up to 4 months of age with stable DDH hips. The switch of 38 infants (12%) from the observation to the treatment group corroborates that not all infantile DDH hips will spontaneously progress into normal hips. The small study population sizes and methodological heterogeneity warrant a large randomised controlled trial to study this research question.PROSPERO registration numberCRD4202123300.
Self-reported measurements of physical literacy in adults: a scoping review
Authors: Ryom Knud , Hargaard Anne-Sofie , Melby Paulina Sander , Maindal Helle Terkildsen , Bentsen Peter , Ntoumanis Nikos , Schoeppe Stephanie , Nielsen Glen , Elsborg Peter 
Published: September 2022

Physical literacy (PL) is a comprehensive concept covering motivation, confidence, physical competence, knowledge and understanding of individuals’ physical activity throughout life. PL has three overlapping domains, such as: an affective, a physical and a cognitive domain. So far, PL has not been measured in the adults and no complete measurement has been developed to date.ObjectivesThe aim of this scoping review was to review existing self-reported instruments measuring different elements of domains of PL.MethodWe reviewed Education Research Complete, Cochrane, Medline, ScienceDirect, Scopus and SPORTDiscus. The reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Studies were coded using a thematic framework, which was based on the three domains of PL. The eligibility criteria were as follows: (1) age groups between 18 and 60 years; (2) meta-analyses, reviews or quantitative studies focusing on the measurement of at least one of the three domains of PL and (3) instrument that was self-reported. We finalised search on 1 August 2021ResultsIn total, 67 articles were identified as studies describing instruments reflecting the three domains of PL. Following full-text reading, 21 articles that met our inclusion criteria were included. Several instruments of relevance to PL are available for assessing motivation, confidence and the physical domain. However, few instruments exist that measure elements of the cognitive domain.ConclusionThis review showed that a range of existing and validated instruments exists, covering two out of the three domains of PL, namely affective and physical domains. However, for the knowledge domain no valid measurement tools could be found. This scoping review has identified gaps in the research (namely the cognitive domain) and also a gap in the research as no measures that consider the inter-relatedness of the three domains (holistic nature of the concept).