bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and mortality among children with anorectal malformation: A multi‐country analysis
Authors: Kancherla Vijaya , Sundar Manasvi , Tandaki Lucita , Lux Anke , Bakker Marian K , Bergman Jorieke EH , Bermejo‐Sánchez Eva , Canfield Mark A. , Dastgiri Saeed , Feldkamp Marcia L. , Gatt Miriam , Groisman Boris , Hurtado‐Villa Paula , Kallen Kärin , Landau Danielle , Lelong Nathalie , Lopez‐Camelo Jorge , Martinez Laura Elia , Mastroiacovo Pierpaolo , Morgan Margery , Mutchinick Osvaldo M. , Nance Amy E. , Nembhard Wendy N. , Pierini Anna , Sipek Antonin , Stallings Erin B. , Szabova Elena , Tagliabue Giovanna , Wertelecki Wladimir , Zarante Ignacio , Rissmann Anke 
Published: November 2022

AbstractPurposeWe examined the total prevalence, trends in prevalence, and age‐specific mortality among individuals with anorectal malformation (ARM)MethodsWe conducted a retrospective cohort study using data from 24 population‐ and hospital‐based birth defects surveillance programs affiliated with the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) from 18 countries and for births from 1974 to 2014. We estimated pooled and program‐specific total prevalence per 10,000 total births. Poisson regression was used to assess time trends in prevalence from 2001 to 2012 when most programs contributed data. We calculated selected age‐specific proportions of deaths, stratified by case statusResultsThe pooled total prevalence of ARM was 3.26 per 10,000 total births (95% Confidence Interval = 3.19, 3.32) for birth years 1974–2014. About 60% of cases were multiple or syndromic. Prevalence of multiple, syndromic, and stillborn cases decreased from 2001 to 2012. The first week mortality proportion was 12.5%, 3.2%, 28.3%, and 18.2% among all, isolated, multiple, and syndromic cases, respectivelyConclusionsARM is relatively rare, with multiple and syndromic cases showing decreasing prevalence during the study period. Mortality is a concern during the first week of life, and especially among multiple and syndromic cases. Our descriptive epidemiological findings increase our understanding of geographic variation in the prevalence of ARM and can be used to plan needed clinical services. Exploring factors influencing prevalence and mortality among individuals with ARM could inform future studies.
Unique hepatic manifestations of COVID‐19‐induced immune dysregulation in children
Authors: Kleinhenz Julia , Wagner Ellen , Afzal Sarah Y. , Shaarbaf Homa , De Avila Jorge Luis , Azzam Ruba 
Published: November 2022

AbstractThe two cases we present are the first to demonstrate novel manifestations of COVID‐19 related interaction between the liver and the immune system in pediatric patients. Written informed consent was obtained from the parent/guardian to publish this report in accordance with the journal's patient consent policy.
Secondary hemophagocytic lymphohistiocytosis triggered by peripheral T‐cell lymphoma: An unusual case report
Authors: Che Yuxuan , Xu Liye , Zhang Xian , Qiu Xun , Song Jincheng , Ding Xiaolei , Sun Xiuhua 
Published: November 2022

AbstractHemophagocytic lymphohistiocytosis (HLH) is a severe syndrome of pathological immune activation caused by activated macrophages and cytotoxic T cells. We report a 65‐year‐old male Chinese patient with typical HLH features caused by peripheral T‐cell lymphoma and then received chemotherapy. However, though the patient's symptoms and signs improved much, his liver function, especially bilirubin, worsened which could be caused by overwhelming cytokines production. Therefore, plasmapheresis was conducted two times and then his liver function significantly recovered. The patient got temporary remission and good quality of life for nearly 2 months but died because of disease progression. In conclusion, as HLH is associated with multiorgan failure, high rates of morbidity and mortality, there are three points to be mentioned. First, it is critical that HLH should be screened as early as possible and initiate effective therapies. Second, plasmapheresis could be a useful method to eliminate excess cytokines production and improve liver function. Third, organs support and nutrient supply are also necessary and important.
Hyphema and secondary glaucoma as a presenting complaint in a dog with chronic lymphocytic leukemia
Authors: Dehghanpir Shannon D. , Sheridan Colleen , Evans Dawn , Lewin Andrew C. , Boudreaux Bonnie , Carter Renee T. 
Published: November 2022

AbstractA 5‐year‐old Pomeranian was diagnosed with anterior uveitis, hyphema, and secondary glaucoma OD. Concurrent retinal hemorrhage, perivascular sheathing, and papilledema were identified OS. Work‐up identified small cell lymphocytosis (>900 × 109/L), anemia, and thrombocytopenia. The patient was diagnosed with B‐cell chronic lymphocytic leukemia as a cause of the ocular findings.
Osilodrostat‐induced adrenal insufficiency in a patient with Cushing's disease
Authors: Ekladios Catherine , Khoury Jessica , Mehr Shahzad , Feghali Krystel 
Published: November 2022

AbstractCushing's disease is a rare condition caused by a benign pituitary tumor underlying adrenocorticotropic hormone excess. Medical treatment is implemented when surgical resection is not curative. We present a case of Cushing's disease with recurrence of macroadenoma who developed iatrogenic adrenal insufficiency in the setting of Osilodrostat treatment.
Comprehensive Combustion Performances of Water Hyacinth and Pistia stratiotes Pellet Fuels
Authors: Hu Yuwei , Meng Junquan , Liu Zhenrong , Yue Hanhong , Zhang Xia , Zhang Yancheng , Chen Rong 
Published: November 2022

AbstractFor efficient combustion of aquatic biomass, the effects of heating rate on the combustion and dynamic characteristics of two typical aquatic species (water hyacinth, Pistia stratiotes), and the effects of temperature and additives on ash K and Cl concentrations are studied. The two types of pellets have ignition temperatures of 252.7 and 250.3 °C, respectively. At a heating rate of 10 °C min−1, where combustion is most stable, the comprehensive combustion efficiencies reach their maximum at 4.7 × 10−6 and 2.2 × 10−6 mg2min−1°C−2, respectively. The K and Cl concentrations in the ash decrease steadily with increasing temperature, falling to 10.3% and 0.41% for water hyacinth and 11.1% and 1.85% for P. stratiotes, respectively. X‐ray diffraction (XRD)shows that abundant Ca minerals form in the ash after the addition of CaO, which inhibit KCl formation, and K and Al silicates form in the ash after the addition of kaoline, which reserve K in the ash. These findings provide a starting point for the development of efficient aquatic biomass combustion.
Fatigue of Donor‐Acceptor Stenhouse Adducts in Polymer Matrices and Solution
Authors: McDonough Rowan , Rudgley Nick , Majewski Oskar , Perkins Michael V. , Evans Richard A. , Lewis David A. 
Published: November 2022

AbstractThe fatigue performance of a range of donor‐acceptor‐Stenhouse‐adducts (DASAs) has been investigated to identify degradation mechanisms. The dyes were found to fatigue with and without exposure to light in both solution and in films. Excluding light below about 430 nm resulted in almost complete thermal recovery after exposure, however, a range of common film additives including hindered amine light stabilizers (HALS) and other additives (especially bases) were shown to react with the DASAs resulting in irreversible fatigue. The rate of fatigue was also found to increase with the relative strength of the donor and acceptor moieties in the molecule.
A novel adaptive invasive weed optimization technique and least square regression for harmonics minimization in standalone PV applications
Authors: Ahmad Ganie Zahoor , Hamid Bhat Abdul , Ahmad Salman 
Published: November 2022

SummaryA novel adaptive invasive weed optimization technique is presented in this paper for harmonics minimization in standalone system based on three‐phase two‐level voltage source inverter. The low switching frequency techniques are preferred to produce good quality waveform and at the same time to reduce the switching losses and device stresses. Nonetheless, the challenging task is to compute the firing angles from the set of highly nonlinear transcendental system of equations. The proposed technique shows faster convergence and capability to compute in wide rage of modulation index. Moreover, multiple solutions also have been obtained in most of the range of modulation index. Various cases have been evaluated and simulation results have been given to validate conceptual results. The closed loop operation and the real‐time implementation of the proposed technique under dynamic operating conditions have been verified for a three‐phase induction motor load using PI controller. The least square regression is used for real‐time implementation of the proposed technique. The TMS320F2812 digital signal processor (DSP) has been employed to generate the pulse width modulated pulses generated from the computational results. The experimental results obtained are in very close concurrence to the computational and simulation results.
Current estimation of switched reluctance motor based on piecewise model and iteration calculation
Authors: Fang Chenghui , Chen Hao , Wang Xing , Zhang Jingxin , Li Ye , Torkaman Hossein , Saqib Muhammed Asghar 
Published: November 2022

SummaryTo reduce the number of current sensors in the switched reluctance motor (SRM) system, a current estimation method of the SRM is proposed. There is only one current sensor needed to measure the sum of phase currents. Current estimation model consists of two equations, one is equation of the sum of phase currents and another is mechanical equation of the SRM. Torque, a variable in the mechanical equation, has complex nonlinear relation with phase currents. This makes it difficult to solve the current estimation model online. To deal with the problem, a piecewise modeling method is used to establish a simple analytical torque model. Accuracy of the established torque model is better than that of traditional torque models after comparisons. A parameter of speed and acceleration is defined to compensate errors of the torque model and avoid identifications of moment of inertia and friction coefficient. On the basis of features of the current estimation model and phase currents of the SRM, Newton's method is chosen to solve the current estimation model and a practical stop condition of iteration is given. Realization process of online computation is illustrated. Finally, the proposed current estimation method is validated by experiments.
Biochemical predictors of diabetic foot osteomyelitis: A potential diagnostic role for parathormone
Authors: Caruso Paola , Maiorino Maria Ida , Scappaticcio Lorenzo , Porcellini Chiara , Matrone Rita , Cirillo Paolo , Macera Margherita , Gicchino Maurizio , Vietri Maria Teresa , Bellastella Giuseppe , Coppola Nicola , Esposito Katherine 
Published: November 2022

AbstractAimsThe aims of this study were to evaluate parathormone (PTH) levels in people with diabetic foot ulcers (DFU) and investigate the relationship between PTH levels and osteomyelitis (OM) in this population.Materials and MethodsEighty‐eight patients were admitted for DFU in a tertiary‐care centre from October 2021 to May 2022. OM was diagnosed by clinical, laboratory, and radiological evaluations. Laboratory measurements and clinical parameters were collected from medical records. Participants in the study were divided into two groups according to the diagnosis of OM (patients with OM, group 1 [n = 54] and patients without OM, group 2 [n = 34]).ResultsCompared with group 2, patients in group 1 were younger and had a longer duration of diabetes. Erythrocyte sedimentation rate and fibrinogen were significantly higher in group 1 compared with group 2. PTH levels were significantly lower (group 1 vs. group 2, median [interquartile range] 16.2 (11.6, 31.0) vs. 23.7 (17.0, 38.1), p = 0.008) and alkaline phosphatase was significantly higher (97.0 (79.0, 112.0) vs. 88.0 (63.0, 107.0), p = 0.031) in group 1. In multiple linear regression analysis, the only independent predictors of PTH concentrations were alkaline phosphatase levels (β‐coefficient 0.441, p < 0.001) and the presence of OM (β‐coefficient −0.290, p = 0.038).ConclusionsIn a population of patients with diabetes and OM admitted to a tertiary university centre, PTH levels were lower as compared with diabetic individuals without OM. The OM and alkaline phosphatase levels were independent predictors of PTH levels in this selected population.
Effectiveness of accelerated reader on children's reading outcomes: A meta‐analytic review
Authors: Tischner Clair M. , Ebner Sara E. , Aspiranti Kathleen B. , Klingbeil David A. , Fedewa Alicia L. 
Published: November 2022

Accelerated reader (AR) is a computerized reading program commonly used in schools. The program aims to enhance students' reading achievement and encourage students to read more through goal setting and frequent reading practice. A meta‐analytic review of the AR was conducted to analyse its effectiveness as an evidence‐based intervention for improving student reading achievement, attitude, and motivation. This study investigated potential moderating variables, including publication type, participant, and study characteristics that impact student reading outcomes. A total of 44 studies from peer‐reviewed journal articles and dissertations met the inclusion criteria. Participants included 16,653 students enrolled in elementary, middle, and high school. Hedges' g effect sizes measures suggest pretest–posttest one‐group AR studies have moderate effects (g = 0.541) while comparison group AR studies have marginal effects (g = 0.278). A meta‐regression model of six potential categorical moderators of comparison group studies indicted no significant moderators. Implications and the need for further research regarding evidence‐based and culturally appropriate reading interventions are discussed.
A comparison of central‐tendency and interconnectivity approaches to clustering multivariate data with irregular structure
Authors: Tozer Mark , Keith David 
Published: November 2022

AbstractQuestionsMost clustering methods assume data are structured as discrete hyperspheroidal clusters to be evaluated by measures of central tendency. If vegetation data do not conform to this model, then vegetation data may be clustered incorrectly. What are the implications for cluster stability and evaluation if clusters are of irregular shape or density?LocationSoutheast Australia.MethodsWe define misplacement as the placement of a sample in a cluster other than (distinct from) its nearest neighbor and hypothesize that optimizing homogeneity incurs the cost of higher rates of misplacement. Chameleon is a graph‐theoretic algorithm that emphasizes interconnectivity and thus is sensitive to the shape and distribution of clusters. We contrasted its solutions with those of traditional nonhierarchical and hierarchical (agglomerative and divisive) approaches.ResultsChameleon‐derived solutions had lower rates of misplacement and only marginally higher heterogeneity than those of k‐means in the range of 15–60 clusters, but their metrics converged with larger numbers of clusters. Solutions derived by agglomerative clustering had the best metrics (and divisive clustering the worst) but both produced inferior high‐level solutions to those of Chameleon by merging distantly‐related clusters.ConclusionsGraph‐theoretic algorithms, such as Chameleon, have an advantage over traditional algorithms when data exhibit discontinuities and variable structure, typically producing more stable solutions (due to lower rates of misplacement) but scoring lower on traditional metrics of central tendency. Advantages are less obvious in the partitioning of data from continuous gradients; however, graph‐based partitioning protocols facilitate the hierarchical integration of solutions.
Geographic factors and climatic fluctuation drive the genetic structure and demographic history of Cycas taiwaniana (Cycadaceae), an endemic endangered species to Hainan Island in China
Authors: Wu Li‐Xin , Xu Hai‐Yan , Jian Shu‐Guang , Gong Xun , Feng Xiu‐Yan 
Published: November 2022

AbstractHainan Island had experienced several cold–warm and dry–humid fluctuations since the Late Pleistocene period, resulting in separating and connecting from the mainland several times with the cyclic rise and fall of sea level. The fluctuations can change the biota and ecological environment in the island. Cycas taiwaniana Carruthers is endemic to Hainan Island and is classified as endangered by the International Union for Conservation of Nature (IUCN). To comprehensively understand the genetic dynamics of C. taiwaniana, we sampled 12 wild populations in Hainan Island and one cultivated population in Fujian province, and analyzed the genetic diversity, genetic structure, and demographic history based on the molecular data. Results revealed that C. taiwaniana had relatively low genetic diversity and high genetic differentiation. Haplotypes of C. taiwaniana diversified during the Pleistocene based on the chloroplast DNA (cpDNA) and the concatenated nuclear DNA (nDNA) data. Genetic cluster analyses based on the microsatellite (SSR) data showed that the 12 wild populations were separated into three clusters which could be three evolutionary significant units (ESUs), indicating three basic units of protection were identified. Moreover, we also confirmed the cultivated population FJ derived from the DLS1‐GSL clade. Demographic inference from different data was discordant, but overall, it uncovered that C. taiwaniana had experienced population contraction events twice during the Pleistocene and Holocene, and then expanded recently. Our study elucidated the population genetic characteristics of C. taiwaniana, and guided us to develop targeted conservation and management strategies for this endangered species.
Fulminant myocarditis with COVID‐19 infection having normal C‐reactive protein and serial magnetic resonance follow‐up
Authors: Usui Eisuke , Nagaoka Eiki , Ikeda Hiroshi , Ohmori Mari , Tao Susumu , Yonetsu Taishi , Maejima Yasuhiro , Arai Hirokuni , Amemiya Kisaki , Ikeda Yoshihiko , Sasano Tetsuo 
Published: November 2022

AbstractA 44‐year‐old woman who was quarantined for 5 days after the diagnosis of coronavirus disease of 2019 (COVID‐19) was transferred to our hospital with the complaint of chest pain. The patient was unvaccinated. Electrocardiography revealed ST elevation in the lateral leads. Echocardiographic biventricular dysfunction with oedematous wall thickening was identified. Cardiac enzyme levels were elevated; however, C‐reactive protein (CRP) levels, and the coronary angiogram were normal. The patient required mechanical circulatory support to stabilize haemodynamics and was treated with remdesivir, baricitinib, and intravenous methylprednisolone. She recovered after 13 days of mechanical support. Serial cardiac magnetic resonance imaging revealed acute myocardial oedema and subsequent fibrosis. An endomyocardial biopsy on admission showed mild interstitial inflammatory infiltrates with endomyocardial fibrous thickening and mild interstitial fibrosis of the myocardium. Normal CRP levels suggested minor involvement of interleukin (IL)‐6, supporting the efficacy of baricitinib.
Knockout of SLy1 decreases double‐negative thymocyte proliferation and protects mice from p53‐induced tumor formation
Authors: Gruber Lena‐Christin , Schneider Barbara , Nothnagel Christin , Beer‐Hammer Sandra 
Published: November 2022

AbstractThe lymphocyte‐specific adapter protein SLy1 has previously been identified as indispensable for thymocyte development and T‐cell proliferation and, recently, as a cause of X‐linked combined immunodeficiency in humans that recapitulates many of the abnormalities reported in SLy1KO and SLy1d/d mice. As SLy1KO NK cells show increased levels of p53, we focused our research on the interdependency of SLy1 and p53 for thymocyte development. Using RT‐PCR and immunoblot analysis, we observed increased levels of p53 as well as DNA damage response proteins in SLy1KO thymocytes. To test for rescue from SLy1‐induced deficiencies in thymocyte development like reduced thymocyte numbers and reduced DN to DP progression, we generated a mouse model with T cell‐specific p53‐deficiency on an SLy1KO background and analyzed lymphocyte populations in these mice and respective controls. Astonishingly, SLy1KO‐typical deficiencies were retained, showing that SLy1 is mechanistically independent of p53. Studies of apoptosis and proliferation in SLy1KO thymocytes revealed decreased proliferation in the DN3 subpopulation as a possible reason for the decreased thymocyte number. In mice with p53‐deficient T cells, we observed tumor formation leading to reduced survival, preferentially in SLy1WT mice. Thus, we suggest that a SLy1‐deficiency reduces proliferation, resulting in less hematologic tumors initiated by the p53‐deficiency.
Synthesis and Characterization of Neutral Cyclometalated Platinum(II) Complexes and their Antibacterial and Cytotoxic Evaluations
Authors: Yu Wai‐Hong , Yiu Sze‐Chun , Lau Mei‐Tung , Ho Po‐Yu , Lam Pik‐Ling , Chui Chung‐Hin , Wong Wai‐Yeung 
Published: November 2022

AbstractA series of neutral cyclometalated platinum(II) complexes bearing 2,6‐bis(2‐naphthyl)pyridine as a C^N^C tridentate chelating ligand with monodentate pyridyl ligands with different substituents 1–3 have been synthesized via double cyclometalation and ligand displacement reaction. The structural, photophysical, electrochemical and aggregation induced emission (AIE) properties of these neutral platinum(II) complexes were systematically studied. Complexes 1–3 exhibited AIE effects with different emission intensities and colors, in which 1 showed the highest quantum efficiency of 8.6 % under aggregated state, and the aggregates were assembled to ordered spheres. Among the Pt(II) complexes, 1 showed a bactericidal activity against both Staphylococcus aureus (S. aureus) (MIC and MBC=3.13 μg/mL) and methicillin‐resistant S. aureus (MRSA) (MIC and MBC=6.25 μg/mL). Complex 1 did not possess noticeable cytotoxicity to human skin HaCaT keratinocytes. The non‐cytotoxic complex 1 would have a good potential to be used for the antibacterial therapy to combat with S. aureus and MRSA‐infected skin diseases.
SENSIBLE: SEquestered aNd SynergIstic BLockchain Ecosystem
Authors: Kshirsagar Meghana , Vaidya Gauri , Yao Yao , Kasar Smita , Ryan Conor 
Published: November 2022

AbstractHealth care interoperability unfolds the way for personalized health care services at a reduced cost. Furthermore, a decentralized system holds the promise to prevent compromises such as cyber‐attacks due to data breaches. Hence, there is a need for a framework that seamlessly integrates and shares data across the system stakeholders. We propose SEquestered aNd SynergIstic BLockchain Ecosystem (SENSIBLE), a blockchain‐powered, knowledge‐driven data‐sharing framework that gives patients complete control of their medical history and can extract rich information hidden in it using knowledge graphs (KGs). By incorporating both blockchain and KGs, we can provide a platform for secure data sharing among stakeholders by maintaining data privacy and integrity through data authentication and robust data integration. We present a Proof‐of‐Concept of the SENSIBLE
network with Ethereum to share dynamic knowledge across stakeholders. Dynamic knowledge generation on the blockchain provides a two‐fold advantage of cooperation and communication amongst the stakeholders in the health care ecosystem. This leads to operational ease through sharing relevant portions of complex information while also ensuring the isolation of sensitive medical data.