bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 21-Year-Old Woman with Suspecting Gitelman Syndrome
Authors: Denny Berty , Agung Prabowo Nurhasan , Puspa Putri Desy , Myrtha Risalina , Apriningsih Hendrastutik 
Published: December 2022

<p><strong>Introduction: </strong>Gitelman syndrome (GS), is a hereditary condition marked by a specific kidney function impairment. GS symptoms do not normally manifest until beyond the age of six years. We present a rare case of a 21-year-old woman with a background in generalized weakness muscle cramps with tetany, fever, and dyspnea. The goal of this study is to give a case report of Gitelman syndrome suspicion.</p><p><strong>Result:</strong> Gitelman syndrome is identified through clinical indicators and lab testing, such as low potassium and magnesium levels in the blood, metabolic alkalosis, and low calcium levels in the urine. We do a variety of physical and laboratory tests to determine the disease and rule out other possibilities. Molecular proof is difficult to get due to a lack of resources and the high expense of genetic testing, which has become one of our case report's flaws. This patient was diagnosed as suspecting Gitelman syndrome and treated for electrolyte imbalances. The patients were given replacement therapy, which comprised intravenous potassium, sodium, and chloride therapy, as well as calcium therapy. In addition, we also provided some symptomatic therapy. She was discharged five days later in fine condition.</p><p><strong>Conclusion :</strong> This is one of the few reports of a 21-year-old lady being suspected of having Gitelman syndrome (GS). We conduct a battery of physical and laboratory tests to diagnose the disease and rule out other possibilities. We provide the appropriate therapies in accordance with the guidelines, and the outcomes are favorable.<em></em></p>
Risk of suicide ideation in comorbid substance use disorder and major depression
Authors: Onaemo Vivian N. , Fawehinmi Timothy O. , D’Arcy Carl 
Published: December 2022

Background
Suicidal behaviour is commonly associated with major depression (MD) and substance use disorders (SUDs). However, there is a paucity of research on risk for suicide ideation among individuals with comorbid SUDs and MD in the general population.

Objectives
This study investigated the associated risk of suicide ideation in comorbid SUDs—cannabis use disorder (CUD), alcohol use disorder (AUD), drug use disorder (DUD) with major depressive episode (MDE) in a nationally representative sample.

Methods
Multilevel logistic regression models were used to analyze the 2012 Canadian Community Health Survey- Mental Health (CCHS-MH) data. This is a cross-sectional survey of nationally representative samples of Canadians (n = 25,113) aged 15 years and older residing in the ten Canadian provinces between January and December 2012. Diagnoses of MDE, AUD, DUD, and CUD were based on a modified WHO-CIDI, derived from DSM-IV diagnostic criteria.

Results
Comorbidity was found to be the strongest predictor of suicide ideation. Compared to those with no diagnosis of either a SUD or MDE, individuals with a comorbid diagnosis of AUD with MDE, CUD with MDE, or DUD with MDE were 9, 11 and 16 times more likely to have 12-month suicide ideation respectively. A diagnosis of MDE was a significant predictor of 12-month suicide ideation with about a 7-fold increased risk compared with individuals not diagnosed with either MDE or a SUD.

Conclusion
Suicide is a preventable public health issue. Our study found a significantly increased risk of suicide ideation among persons who have comorbid SUD with MD. Effective integration of mental health and addictions services could mitigate the risk of suicide and contribute to better outcomes.
Obesity in children and adolescents and the risk of ovarian cancer: A systematic review and dose‒response meta-analysis
Authors: Ding Nan , Zhan Junyi , Shi Youjin , Qiao Tianci , Li Panpan , Zhang Tingting 
Published: December 2022

Objective
The relationship between obesity in children and adolescents and the risk of ovarian cancer remains controversial. The aim of this meta-analysis was to explore the exact shape of this relationship.

Methods
We conducted dose‒response meta-analyses of cohort and case‒control studies, including published studies derived from searches in the PubMed, Embase, Web of Science and Cochrane Library databases until October 2022. Pooled effect size estimates are expressed as relative risks (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) and were evaluated by fixed-effect models. A nonlinear dose‒response meta-analysis was performed by using a restricted cubic spline model.

Results
After screening 4215 publications, 10 studies were included in the present meta-analysis. Overall analyses revealed statistically significant associations of obesity in children and adolescents with ovarian cancer (adjusted RR = 1.19, 95% CI: 1.11 to 1.28, P < 0.001). Moreover, the association was consistently significant in most subgroup analyses, for example, using geographic stratification, the results remained stable both in the Americas(RR = 1.11; 95% CI: 1.01 to 1.21; P = 0.022) and Europe (RR = 1.46; 95% CI: 1.21 to 1.77; P<0.001). For the dose‒response analyses, the risk of ovarian cancer increased with the degree of obesity, and the trend increased rapidly when body mass index (BMI) was over 25.95 kg/m2.

Conclusion
Our findings indicate that obesity in children and adolescents is a risk factor for ovarian cancer, and the risk increases with increasing BMI.
Catquest-9SF questionnaire: Validation in a Greek-speaking population using Rasch analysis
Authors: Nanos Panagiotis , Kouteliari Vasiliki , Panagiotopoulou Eirini-Kanella , Papadopoulos Nikolaos , Ntonti Panagiota , Labiris Georgios 
Published: December 2022

Purpose
The Catquest-9SF questionnaire is a tool measuring visual disability and vision-related limitation in patients’ daily activities. The primary objective of this study was the validation of Catquest-9SF in a Greek-speaking cataract population.

Methods
The questionnaire was translated into Greek and translated back into English. A pre-final Greek version was formed and tested by 10 Greek-English bilingual participants and by the translation team, and the final version was produced. Patients scheduled for cataract surgery completed the questionnaire preoperatively and postoperatively. Rasch analysis was performed for the assessment of the Catquest-9SF psychometric properties, including response category ordering, item fit statistics, principal components analysis, precision, differential item functioning and targeting for preoperative and postoperative data collectively.

Results
A total of 100 (55 men, 45 women, mean age = 71.94±6.63) cataract patients completed the Greek version of Catquest-9SF questionnaire preoperatively and postoperatively. Rasch analysis showed a significant improvement in the median person Rasch score from −1.49 preoperatively to −4.71 logits postoperatively, while the effect size was 1.3. Unidimensionality was confirmed since infit and outfit mean square values varied between 0.66 and 1.37. Rasch analysis showed good precision and separation ability (Person Separation Index of 3.28, and Person Reliability of 0.92). Four response categories were found for all items. The item-person means difference was -1.83 logits. The difference between preoperative and postoperative Catquest-9SF logit score was positively correlated with preoperative Catquest-9SF logit score (coeff. = 0.798, p<0.0001) and negatively correlated with postoperative spherical equivalent (coeff. = -0.825, p = 0.011).

Conclusion
The Greek version of Catquest-9SF proved to be reliable, valid, unidimensional and responsive to changes after cataract surgery presenting good psychometric properties for cataract patients. Some postoperative mistargeting was found indicating that the tasks were easily performed by respondents after cataract surgery.

Trial registration
NCT05323526 -retrospectively registered.
A Produção De Estudos Sobre A Lei 10.639 Nas Regiões Norte E Nordeste / The research about the Law 10.639 in the North and Northeast regions
Authors: Queiroz Delcele Mascarenhas , Macêdo Marluce de Lima 
Published: December 2022

RESUMO: Neste artigo apresentamos uma reflexão acerca da pesquisa acadêmica sobre a Lei 10.639/2003 e/ou temas relacionados à mesma, a partir da presença da temática no Encontro de Pesquisadores em Educação no Norte e Nordeste - EPENN, no período 2003 - quando a lei foi criada -, a 2011. Â A problemática central envolve a análise da presença, amplitude e constância da Lei no âmbito de pesquisas no campo da educação, observando o tratamento dado a esta nos trabalhos desenvolvidos, objetivando discutir as possibilidades de diálogos entre pesquisa e currículo.ABSTRACT: In this paper, we present a reflection about the academic research about the Law 10.639/2003 and/or themes related to it, from the theme's discussion in the researchers' education meeting in the North and Northeast - EPENN, from 2013 - when the law was created - to 2011. The main question involves the presence analysis,breadth and constancy of this law in the education researches, noticing the treatment given to it in the developed studies, aiming discuss the dialogues that are possible between research and curriculum.RÉSUMÉ: Dans cet article nous essayons de présenter une réflexion concernant les travaux scientifiques dont l'objet a été la Loi 10.639/2003 et/ou des questions qui se rapportent à l'application de cette loi. La problématique centrale de l'article se penche sur la présence et l'importance consacrée à cette Loi, notamment dans les Congrès des Chercheurs de l'Éducation du Nord et Nord-Est (EPENN), entre 2003 - lors de sa publication - et 2011. À partir du traitement donné à la Loi 10.639/2003 dans des recherches développées dans le domaine de l'Éducation, on essaye d'analyser les rapports d'interaction qui peuvent être établies entre recherche et curriculum.
ACESSO, PERMANÊNCIA E EXCLUSÃO RACIAL
Authors: Túbero Rosana 
Published: December 2022

O objetivo deste artigo é rever questões de acesso e permanência de alunos negros nos bancos escolares do ensino fundamental e no ensino médio brasileiro e a importância da Lei 10.639/2003 enquanto estratégia de combate às desigualdades educacionais e raciais. Ênfase é dada ao conceito de capital humano opondo-se este à ideia de uma cultura nacional e popular que permita a tomada de consciência da opressão e a organização para a luta contra o modelo vigente. Ao lado de alguns momentos políticos e de políticas educacionais, para demonstrar as desigualdades entre brancos e negros, apresentam-se dados do IPEA, IBGE e de pesquisadores.Palabras-chave: Exclusão. Desigualdades educacionais. Educação antirracista.ACCESS, RETENTION AND RACIAL EXCLUSION Abstract:Â The purpose of this article is to review issues of access and retention of black students in elementary schools and secondary education in Brazil and the importance of Brazilian Law 10.639/2003 as a strategy to fight racial and educational inequalities. Emphasis is given to the concept of human capital, in opposition to the idea of a national and popular culture, allowing awareness of the oppression as well as the organization to fight the current model. Alongside some political moments and educational policies, in order to show the inequalities between blacks and whites, we present data from IPEA, IBGE and research.Keywords: Exclusion. Educational inequalities. Anti-racist education.L'ACCESS, SEJOUR ET L'EXCLUSION RACIALEResumé:Â Le but de cet article c'est d'examiner les questions de l'accès et la rétention des étudiants noirs dans les écoles primaires et l'enseignement secondaire, et l'importance de 10.639/2003 la loi brésilienne en tant que stratégie de lutte contre les inégalités raciales et éducatives. L'accent est mis à la notion du capital humain en opposition à cette idée d'une culture nationale actuelle pour permettre la prise de conscience populaire sur l'oppression et sur l'organisation, pour pouvoir lutter contre le modèle actuel. En fera référence à quelques choix politiques et d'éducation, afin de montrer les inégalités entre Noirs et Blancs. Nous présenterons des données de l'IPEA, l'IBGE et d'autres chercheurs.Mots-clés: Exclusion. Les inégalités scolaires. L'éducation anti-raciste.
Democratic Central Banking: Power Not Deliberation
Authors: Ely Downey Leah Rose 
Published: December 2022

Abstract
Eric Monnet’s piece, “Democratic consequences of the insurance functions of central banks,” starts in exactly the right place. Monnet acutely observes some of the most fundamental issues with the dominant contemporary monetary policymaking regime. Most foundationally, he observes a gap between what central banks do and how they are legitimized. The consequence, in short, is a failure of the contemporary regime to justify itself on democratic terms. To overcome this failure, Monnet proposes an institutional reform—establishing a European Credit Council (ECC). He defends this proposal by appeal to democratic theory, particularly the literature on democratic theory that prizes ‘good deliberation’. While there is nothing wrong with Monnet’s claim that establishing an ECC would likely improve the quality of deliberation about the role of central banks, and in so doing, produce better policy, I argue here that this view misses something essential. Democracy requires more than accountability, transparency, and good deliberation. It requires democratic power: the power of the people and their elected officials to steer policy. Adopting this view of democracy, in contrast to the deliberative democratic view Monnet embraces, suggests a different set of required reforms. Instead of establishing an independent credit council, I suggest that we should be vesting stronger monetary policy guidance powers in existing democratic legislative bodies.
Bioactivity of a polyhydroxy gorgostane steroid from Xenia umbellata
Authors: Bawakid Nahed O. , Althagbi Hanan I. 
Published: December 2022

Abstract
A C-30 steroid, 3β-,5α-,6β-,11α-,20β-pentahydroxygorgosterol was isolated from the soft coral Xenia umbellata Lamarck (Xeniidae). The chemical structure was elucidated by examining the NMR spectral data and comparison with the previously published data. Compound 1 inhibited the growth of ovarian cancer (SKOV-3), breast cancers (MCF-7 and MDA-MB-231) and hepatocellular carcinoma (HepG2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Notably against HepG2, compound 1 showed significant effect with an IC50 value of 19.70 ± 1.98 µg/mL. It significantly increased the population in the SubG1 phase for 2.01- and 2.05-folds, respectively, compared to untreated cells. Additionally, it showed potent inhibitory activities of superoxide dismutase (384.6 vs 8594.2 U/g protein in dimethyl sulfoxide-treated cells), catalase (0.3 vs 0.07 U/g protein), decreased the level of reduced glutathione (1.7 vs 0.6 mg/g protein) and the activity of matrix metalloproteases (MMP-2 and MMP-9 [0.5-fold of change in MMP activity]) in HepG2 cells. The results indicated the potent antiproliferative activity of the gorgostane derivative (1) against HepG2 cells. This study provides a scientific basis of the antiproliferative effects of steroidal compound with gorgostane nucleus against hepatocellular carcinoma cells.
Plant-derived bisbenzylisoquinoline alkaloid tetrandrine prevents human podocyte injury by regulating the miR-150-5p/NPHS1 axis
Authors: Sun Yue , Yuan Chenyi , Yu Jin , Zhu Caifeng , Wei Xia , Yin Jiazhen 
Published: December 2022

Abstract
Podocytes have become a crucial target for kidney disease. Tetrandrine (TET), the main active component of a Chinese medicine formula Fangji Huangqi Tang, has shown a positive effect on various renal diseases. We aimed to investigate the effect and mechanism of TET on podocytes. The targeting relationship between microRNA (miR)-150-5p and nephrosis 1 (NPHS1) was determined by a dual-luciferase reporter gene assay. Cell proliferation, migration, and apoptosis were detected by cell counting kit-8, Transwell, and flow cytometry assays, respectively. The expression of miR-150-5p and NPHS1 was detected by RT-qPCR. The levels of Nephrin, Caspase-3, Bcl-2, Bax, E-cadherin, and α-smooth muscle actin were detected by Western blot. TET prompted cell viability and inhibited migration and apoptosis of puromycin aminonucleoside-induced human podocytes (HPC) in a dose-dependent manner. miR-150-5p directly targeted NPHS1 and was upregulated in damaged HPC. TET decreased the miR-150-5p expression and increased the level of NPHS1 and Nephrin. Overexpressed miR-150-5p inhibited the expression of NPHS1 and Nephrin, and reversed the protective effects of TET on injured HPC. TET protects the biological function of HPC by suppressing the miR-150-5p/NPHS1 axis. It reveals that TET may be a potential drug and miR150-5p is a potential therapeutic target for the treatment of podocyte injury.
Biosynthesis of nano-curcumin/nano-selenium composite and their potentialities as bactericides against fish-borne pathogens
Authors: Gad Hend A. , Alshubaily Fawzia A. , Alsieni Mohammed A. , Tayel Ahmed A. , Diab Amany M. 
Published: December 2022

Abstract
Fish-borne zoonotic bacteria can endanger the health of human and aquatic organisms; the nanobiotechnology applications can help. Curcumin nanoparticles (NC) were synthesized using gum Arabic (GA) and the resulted NC was innovatively employed for mediating selenium nanoparticles (NSe), then each compound/composite was evaluated as candidates for inhibiting fish-borne pathogens (Aeromonas hydrophila, Escherichia coli, Salmonella typhimurium, and Staphylococcus aureus). The nanomaterials’ characterizations revealed the successfulness of their synthesis and conjugation. Promisingly, the NSe had particles’ diameter in the range of 2.4–15.8 nm and mean diameter of 6.1 nm, whereas the NC/NSe particles’ diameter was in the range of 15.4–92.3 nm and their mean diameter was 50.7 nm. The antibacterial activity of biosynthesized NC, NSe, and NC/NSe was validated quantitatively/qualitatively toward all examined bacteria; their powers were sorted as NC < NSe < NC/NSe. A. hydrophila was the most sensitive strain and S. aureus was the most resistant. The scan image of A. hydrophila cells exposed to NC/NSe indicated the high capability of nanocomposite to distort bacterial cells and lead them to death within 10 h of exposure. The biosynthesized NC, NSe, and NC/NSe are substantially advocated as natural biocides for controlling fish-borne zoonotic pathogens.
Statistics, philosophy, and health: the SMAC 2021 webconference
Authors: Savy Nicolas , Moodie Erica EM , Drouet Isabelle , Chambaz Antoine , Falissard Bruno , Kosorok Michael R. , Krakow Elizabeth F. , Mayo Deborah G. , Senn Stephen , Van der Laan Mark 
Published: December 2022

Abstract
SMAC 2021 was a webconference organized in June 2021. The aim of this conference was to bring together data scientists, (bio)statisticians, philosophers, and any person interested in the questions of causality and Bayesian statistics, ranging from technical to philosophical aspects. This webconference consisted of keynote speakers and contributed speakers, and closed with a round-table organized in an unusual fashion. Indeed, organisers asked world renowned scientists to prepare two videos: a short video presenting a question of interest to them and a longer one presenting their point of view on the question. The first video served as a “teaser” for the conference and the second were presented during the conference as an introduction to the round-table. These videos and this round-table generated original scientific insights and discussion worthy of being shared with the community which we do by means of this paper.
Connecting the dots: alterations in bioelectric activity at acupuncture Ting (Jing-Well) points following CV4 cranial manipulation
Authors: Hendryx Jan T. , Kannan Ashok , Prashad Jessica , Falk Karl 
Published: December 2022

AbstractContextThe mechanisms by which osteopathic cranial manipulative medicine (OCMM) promotes health and healing have yet to be fully elucidated. One commonly utilized OCMM technique, compression of the fourth ventricle (CV4), has been theorized to balance autonomic nervous system (ANS) activity. There is growing evidence that the ANS also plays a significant mechanistic role in acupuncture. Potential connections between OCMM and acupuncture meridian theory largely remain unknown.ObjectivesBy measuring specific electrical parameters at acupuncture points that have been shown to correlate with ANS activity, the objectives of this study were to: 1) determine if CV4 has any influence on the bioelectric properties of the acupuncture meridian system; and 2) determine if CV4 affects the ANS.MethodsA total of 77 males and females ages 18–78 years, all volunteers recruited by local flyers and personal or phone contact, were randomized into CV4 (n=40) and Sham (n=37) groups. All CV4 participants were treated by the same physician utilizing standard CV4 protocol. The Sham treatment, performed by a different physician, consisted of the supine participant’s occiput resting passively on the physician’s finger pads for a similar duration as those in the CV4 group. Among several devices developed to assess ANS activity at acupuncture points, evidence suggests that the Apparatus for Meridian Identification (AMI) is the most accurate and valid. Utilizing the AMI, bioelectric skin parameters were measured immediately before and after CV4 or Sham treatments. Student’s or Welch’s t tests and Wilcoxon tests were utilized for analysis of normally and non-normally distributed data, respectively.ResultsStatistical significance was determined with a p value less than 0.05. Sham treatments showed insignificant (p=0.754) before vs. after differences in ANS activity measured at acupuncture points, whereas CV4 treatment significantly (p=0.00015) affected ANS activity.ConclusionsThis research suggests that CV4 has demonstrable biophysical effects on the acupuncture meridian system occurring via the ANS, and that the underlying mechanisms of OCMM and acupuncture may be related. Further studies are needed to clarify this.
A quantitative global test of the complexity trade-off hypothesis: the case of nominal and verbal grammatical marking
Authors: Shcherbakova Olena , Gast Volker , Blasi Damián E. , Skirgård Hedvig , Gray Russell D. , Greenhill Simon J. 
Published: December 2022

AbstractNouns and verbs are known to differ in the types of grammatical information they encode. What is less well known is the relationship between verbal and nominal coding within and across languages. The equi-complexity hypothesis holds that all languages are equally complex overall, which entails trade-offs between coding in different domains. From a diachronic point of view, this hypothesis implies that the loss and gain of coding in different domains can be expected to balance each other out. In this study, we test to what extent such inverse coevolution can be observed in a sample of 244 languages, using data from a comprehensive cross-linguistic database (Grambank) and applying computational phylogenetic modelling to control for genealogical relatedness. We find evidence for coevolutionary relationships between specific features within nominal and verbal domains on a global scale, but not for overall degrees of grammatical coding between languages. Instead, these amounts of nominal and verbal coding are positively correlated in Sino-Tibetan languages and inversely correlated in Indo-European languages. Our findings indicate that accretion and loss of grammatical information in nominal words and verbs are lineage-specific.