bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic options for extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases producing Escherichia coli and Klebsiella sp. isolated from various clinical samples
Authors: Kumar Vimal , Kaur Narinder , Chauhan Shubham , Bala Rosy , Chauhan Jyoti , Kumar Harit , Devi Shivani 
Published: December 2022

Escherichia coli and Klebsiella sp. are the predominant species isolated from clinical samples. Recent and proper understanding of the antibiotic susceptibility pattern of extended-spectrum β-lactamases (ESBL) and AmpC β-lactamases (AmpC) producing E. coli and Klebsiella sp. will prevent the distribution and future incidence of ESBL and AmpC. We designed this study to understand antibiotic susceptibility patterns of ESBL and AmpC producing E. coli and Klebsiella sp. isolated from a tertiary care hospital in North India. A cross-sectional study was conducted from March 2021 to February 2022. Guring this period, various clinical samples were collected and further tested for ESBL producing E. coli and Klebsiella sp. by using the Double disc Synergy test, whereas AmpC was detected by the Boronic acid disk potentiation method. Their antibiotic susceptibility patterns were noted. Various clinical specimens were collected, in which 37.95% were shown growth of bacteria. Among them, 46.67% of E. coli and 25.21% of Klebsiella sp. were identified by standard laboratory protocol. ESBL producing isolates were 44.37% and 34.20% in E. coli and Klebsiella sp., respectively. Whereas AmpC production was detected in 18.27% of E. coli and 29.36% of Klebsiella sp. ESBL and AmpC producing E. coli and Klebsiella sp. isolated from pus, blood, and sputum samples showed the highest sensitivity towards colistin, tigecycline, and imipenem while in urine samples imipenem, meropenem showed the highest sensitivity. Susceptibility patterns of ESBL and AmpC producing E. coli and Klebsiella sp. from various clinical specimens enhance hospital infection management and help clinicians to prescribe the appropriate antibiotics. The carbapenem, nitrofurantoin, colistin and tigecycline were showed highest susceptible against ESBL and AmpC producing E. coli and Klebsiella sp.
Pathological fracture in fibrous dysplasia: a case report
Authors: Supriyadi Bambang 
Published: December 2022

Fibrous dysplasia (FD) is described as a growth disorder characterized by the progressive replacement of normal bone elements by fibrous-osseus tissue. Bones affected by FD is presented with bone weakening and prone to pathological fracture. We reported a case of FD in an 8-years-old boy, who came to the hospital with pain in the upper right thigh after falling with bumps in his head and foot. An X-ray revealed a deformity as a diasteal scalloping with radiolucency lesions on one-third proximal of the right upper femur, greater trochanter, and lesser trochanter, with complete transverse discontinuity in the distal deformity. No similar lesion was found in the other bones. Bone structure and trabeculation in the deformity area has decreased and the cortex was thinning. On magnetic resonance imaging (MRI), bone size was enlarged, hypointense on T1WI and inhomogeneous hyperintense on T2WI. Fibrous dysplasia with a pathological fracture is a rare case. The appearance on the X-ray was diasteal scalloping with a ground-glass radiolucency represented with Shepherd's crook deformity. This lesion was accompanied by a pathological fracture (fragility fracture) on distal lesion. Fibrous dysplasia which characterized by bone developmental anomaly gave an inhomogeneous hypointense on T1W1 and hyperintense on T2WI.
Failure Characteristics and Scale in a Sandstone Joint Subjected to Direct Shear Testing: Experimental Investigation with Acoustic Emission Monitoring
Authors: Liu Chang , Feng Guang-Liang , Zhu Chun , Xu Ding-Ping 
Published: December 2022

Abstract
An in-depth recognition of the failure characteristics and scale of joints is of great significance for the stability assessment in rock engineering. Unfortunately, due to the close fitting of the upper and lower blocks of the joint under direct shear tests, the shear failure of joints are difficult to observe directly during the shear process. Thus, in this work, direct shear tests were carried out on sandstone joints subjected to three levels of normal stress while the acoustic emission (AE) in the rock is synchronously monitored. The failure characteristics of rock joints were then investigated by calibrating the AE system and combining them with the AE location results and shear load curves. A method was established to determine the failure scale of the rock joint that uses the AE moment tensor and first law of thermodynamics. The results show that the degree of failure of the rock joints increases as the normal stress increases. Also, the shear failure of the rock joints is localized and occurs synchronously, rather than sequentially in different areas. The average length of the microfractures formed in the shear process correlates with the average mineral grain size. On the other hand, the maximum length of the microfractures appears to have different values depending on the normal stress present. Our results have significant reference value for the precursory identification of shear disaster in engineering rock masses.
Geochronology, Geochemistry, and Geodynamic Implications of Permo-Triassic Back-Arc Basin Successions in the North Pamir, Central Asia
Authors: Rembe Johannes , Sobel Edward R. , Kley Jonas , Terbishalieva Baiansulu , Musiol Antje , Chen Jie , Zhou Renjie 
Published: December 2022

Abstract
The Permo-Triassic period marks the time interval between Hercynian (Variscan) orogenic events in the Tien Shan and the North Pamir, and the Cimmerian accretion of the Gondwana-derived Central and South Pamir to the southern margin of the Paleo-Asian continent. A well-preserved Permo-Triassic volcano-sedimentary sequence from the Chinese North Pamir yields important information on the geodynamic evolution of Asia’s pre-Cimmerian southern margin. The oldest volcanic rocks from that section are dated to the late Guadalupian epoch by a rhyolite and a dacitic dike that gave zircon U-Pb ages of ~260 Ma. Permian volcanism was largely pyroclastic and mafic to intermediate. Upsection, a massive ignimbritic crystal tuff in the Chinese Qimgan valley was dated to 244.1±1.1 Ma, a similar unit in the nearby Gez valley to 245±11 Ma, and an associated rhyolite to 233.4±1.1 Ma. Deposition of the locally ~200 m thick crystal tuff unit follows an unconformity and marks the onset of intense, mainly mafic to intermediate, calc-alkaline magmatic activity. Triassic volcanic activity in the North Pamir was coeval with the major phase of Cimmerian intrusive activity in the Karakul-Mazar arc-accretionary complex to the south, caused by northward subduction of the Paleo-Tethys. It also coincided with the emplacement of basanitic and carbonatitic dikes and a thermal event in the South Tien Shan, to the north of our study area. Evidence for arc-related magmatic activity in a back-arc position provides strong arguments for back-arc extension or transtension and basin formation. This puts the Qimgan succession in line with a more than 1000 km long realm of extensional Triassic back-arc basins known from the North Pamir in the Kyrgyz Altyn Darya valley (Myntekin formation), the North Pamir of Tajikistan and Afghanistan, and the Afghan Hindukush (Doab formation) and further west from the Paropamisus and Kopet Dag (Aghdarband, NE Iran).
Factors associated with prolonged length of hospital stay in primary total knee arthroplasty following enhanced recovery after surgery protocol：a single‑center retrospective study
Authors: Wei Changbao , Ji Yuan , Gu Sanjun , Liu Yu , Shao Mu , Yin Qin , Li Haifeng 
Published: December 2022

Abstract
Background
Decreasing the length of stay (LOS) is an ideal way to appropriately allocate medical and health resources. This study aims to analyze the risk factors of prolonged LOS after total knee arthroplasty (TKA) following enhanced recovery after surgery (ERAS) protocol.
Methods
220 patients who underwent primary TKA in strict accordance with ERAS protocol from January 2018 to December 2021 were included in the retrospective study. Prolonged LOS was defined as more than 5 days. The factors with a P value less than 0.1 in the univariate analysis were further analyzed in a multivariate model. A binary Logistic regression was performed to screen the independent risk factors for a prolonged LOS.
Results
Binary Logistic regression multivariate analysis showed patients' age (OR = 3.320, 95%CI 1.209–9.115, P = 0.020), complications of ischemic heart disease (OR = 4.917, 95%CI 1.046–23.114, P = 0.044), operation time (OR = 1.966, 95%CI 1.006–3.840, P = 0.048) and surgical day of the week (OR = 0.268, 95%CI 0.092–0.786, P = 0.016) were independent risk factors for prolonged LOS. Further stratified analysis showed that patients older than 70 years had 3.32 times the risk of prolonged LOS compared with patients younger than 60 years. Patients with more than 90 minutes of surgery had 1.966 times the risk of prolonged LOS compared with patients with less than 90 minutes of surgery. Having surgery on Monday is significantly associated with the highest odds of prolonged LOS.
Conclusions
Patients older than 70 years, operation time of more than 90 minutes, with ischemic heart disease, and having surgery on Monday are independent risk factors for prolonged LOS after TKA following ERAS protocol. Early identification and optimization of these factors can help shorten LOS and further maximize the use of medical resources.
The effectiveness of clinical guideline implementation strategies in oncology: a systematic review
Authors: Bora Ana-Mihaela , Piechotta Vanessa , Kreuzberger Nina , Monsef Ina , Wender Andreas , Follmann Markus , Nothacker Monika , Skoetz Nicole 
Published: December 2022

Abstract
Importance: Guideline recommendations do not necessarily translate into changes in clinical practice behaviour or better patient outcomes.
Objective: This systematic review aims to identify recent clinical guideline implementation strategies in oncology and to determine their effect primarily on patientrelevant outcomes and secondarily on healthcare professionals' adherence.
Evidence Review: A systematic search of five electronic databases (PubMed, Web of Science, GIN, CENTRAL, CINAHL) was conducted between August and September 2021. Randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSIs) assessing the effectiveness of guideline implementation strategies on patient-relevant outcomes (overall survival, quality of life, adverse events) and healthcare professionals' adherence outcomes (screening, referral, prescribing, attitudes, knowledge) in the oncological setting, were targeted. The Cochrane risk-of-bias tool and the ROBINS-I tool were used for assessing the risk of bias. Certainty of evidence was evaluated according to GRADE recommendations.
Findings: Of 1058 records identified, six studies, two stepped-wedge cluster RCTs and four controlled before-and after studies, were included in the narrative synthesis. All six studies assess the effect of multi-component interventions in 2024 cancer patients and 281 healthcare professionals. None of the included studies reported overall survival and adverse events. Compared to no intervention, educational meetings combined with materials, opinion leaders, audit and feedback, and a tailored intervention or academic detailing may slightly increase referral rates. Still, the certainty in this evidence is low. The effect of multi-component interventions compared to no intervention on the quality of life of cancer patients and screening rates, prescribing behaviour, attitudes, and knowledge of healthcare professionals is very uncertain.
Conclusions and Relevance: Knowledge and skill accumulation through team-oriented or online educational training and dissemination of materials embedded in multi-component interventions seem to be the most frequently researched guideline implementation strategies in the last years in oncology. This systematic review cannot conclude which implementation strategy or combination of strategies is most effective, still, it gives an overview of recent strategies used for guideline implementation in oncology and can inform policymakers, professional organisations, and institutions on the development and adoption of implementation strategies.
Using expert and spectral methods to assess visually attractive urban informal green spaces in Lublin, Poland.
Authors: Kamiński Jan , Soszyński Dawid , Trzaskowska Ewa , Stuczyński Tomasz , Siebielec Grzegorz , Głowienka Ewa , Poręba Ludwika 
Published: December 2022

Abstract

The objectives of the study is to develop the criteria for
expert assesment of visual attractiveness of informal urban green
spaces and compare results with indicators derived from spectral
indexes and GIS data. The study area is Lublin in Poland, a
medium-sized European city. Expert assessment includes: general
assessment - defining overall attractiveness, naturalness,
landscape contrast and uniqueness. We juxtaposed the results with
spectral indexes and GIS data. The analyses were performed for the
target areas and a 300 m buffers around them. The spectral indexes
largely confirm the results of the expert assessment. Clear
relationship exists between overall attractiveness and temperature
and between landscape contrast and temperature. Areas with greater
landscape contrast also have a larger difference in index values
between the area and the buffer. There is a positive correlation
between overall attractiveness and land slope. Spectral indexes
also indicated the value of some sites that received a lower expert
assessment. We suggest that the most visually attractive areas be
called “enchanted natural places" (ENPs) as a tool for formalising
the protection of these areas. Spectral indexes confirm the values
of ENPs, but also shown the value of sites with lower expert
assessment, more common “bushes and shrubs”.
Mutations in the B30.2 and the Central Helical scaffold domains of pyrin differentially affect inflammasome activation
Authors: chirita Daria , Magnotti Flora , Bronnec Pauiine , Dalmon Sarah , Martin Amandine , Popoff michel , Gerfaud-Valentin Mathieu , Seve Pascal , Belot Alexandre , Contis Anne , Duquesne Agnes , nocturne gaetane , lemelle Irene , Georgin-Lavialle Sophie , Boursier Guilaine , Touitou Isabelle , Jamilloux Yvan , Henry Thomas 
Published: December 2022

Abstract
Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disorder. FMF is caused by mutations in the MEFV gene, encoding pyrin, an inflammasome sensor. The best characterized pathogenic mutations associated with FMF cluster in exon 10. Yet, mutations have been described along the whole MEFV coding sequence. Exon 10 encodes the B30.2 domain of the pyrin protein, but the function of this human-specific domain remains unclear. Pyrin is an inflammasome sensor detecting RhoA GTPase inhibition following exposure to bacterial toxins such as TcdA. Here, we demonstrate that the B30.2 domain is dispensable for pyrin inflammasome activation in response to this toxin. Deletion of the B30.2 domain mimics the most typical FMF-associated mutation and confers spontaneous inflammasome activation in response to pyrin dephosphorylation. Our results indicate that the B30.2 domain is a negative regulator of the pyrin inflammasome that acts independently from and downstream of pyrin dephosphorylation. Additionally, we identify the central helical scaffold (CHS) domain of pyrin, which lies immediately upstream of the B30.2 domain as a second regulatory domain. Mutations affecting the CHS domain mimic pathogenic mutations in the B30.2 domain and render the pyrin inflammasome activation under the sole control of the dephosphorylation. In addition, specific mutations in the CHS domain strongly increase the cell susceptibility to steroid catabolites, recently described to activate pyrin, in both a cell line model and in monocytes from genotype-selected FMF patients. Taken together, our work reveals the existence of two distinct regulatory regions at the C-terminus of the pyrin protein, that act in a distinct manner to regulate positively or negatively inflammasome activation. Furthermore, our results indicate that different mutations in pyrin regulatory domains have different functional impacts on the pyrin inflammasome which could contribute to the diversity of pyrin-associated autoinflammatory diseases.
Overcoming Strength-Ductility Trade-off by Annealing Induced Lattice Defects Reorganization in a Shock-Loaded CrCoNi-based Medium-Entropy Alloy
Authors: Shan Guibin , An Minrong , Wang Cunxian , Dong Hao , Zhao Feng , Cong Yubin , Jiang Kun , Ye Tian , Li Jianguo , Liu Feng , Suo Tao , Chen Yuzeng 
Published: December 2022

Abstract
Annealing of cold-deformed metals often leads to softening of the metals due to the annihilation of lattice defects produced upon deformation. Here we show that in a shock-loaded CrCoNi-based medium-entropy alloy, the yield strength is enhanced by 33% and ductility is substantially improved by 19% after low-temperature annealing treatment. The improved properties stem from the ultra-high density lattice defects (dislocations, stacking faults and twins) produced upon a novel dynamic equal channel angular pressing at liquid nitrogen temperature under an ultra-high strain rate of 1.17 × 105 s− 1. Reorganization of lattice defects to nanotwins via the expansion of initial nanotwins or the glide of partial dislocations occurs during the annealing treatment. The nanotwins can exert strong interaction with the dislocations and thus produce substantial strengthening and increase the strain-hardening capability of alloys. These results provide insights into understanding the annealing strengthening mechanisms in severely plastic-deformed metals.
Mechanosensitive non-equilibrium supramolecular polymerization in closed chemical systems
Authors: Lang Xianhua , Huang Yingjie , He Lirong , Wang Yixi , Thumu Udayabhaskararao , Chu Zonglin , Huck Wilhelm , Zhao Hui 
Published: December 2022

AbstractInspired by biofuel-driven dissipative self-assembly in nature, chemical fuel-driven supramolecular systems have been developed showing out-of-equilibrium functions such as transient gelation and oscillations. However, these systems suffer from undesired waste accumulation and they function only in open systems. Herein, we report non-equilibrium supramolecular polymerizations in closed chemical systems. The system is built by viologens and pyranine in the presence of hydrazine hydrate. On shaking, the viologens were quickly activated by oxidation by air followed by self-assembly of pyranine into micrometer-sized nanotubes. The self-assembled nanotubes disassembled spontaneously over time by the reduced agent, with nitrogen as the only waste product. The dissipative supramolecular polymerization could be repeated at least 6 times even in a closed system. Our mechanosensitive dissipative self-assembly process could be extended to fabricate a chiral transient supramolecular helix by introducing chiral charged small molecules into the system. More specifically, we show that shaking could induce transient fluorescence enhancement or quenching depending on substitution of viologens. Ultrasound was introduced as a specific shaking way to generate template-free reproducible patterns.
Unsupervised hierarchical clustering of 31,000 autistic individuals identifies three distinct groups of language comprehension abilities
Authors: Vyshedskiy Andrey , Venkatesh Rohan , Khokhlovich Edward 
Published: December 2022

Abstract
The fundamental question of language acquisition has intrigued humanity since the beginning of recorded history. One of the earliest testaments to this has been left by Greek historian Herodotus, who described a legendary experiment conducted by the Egyptian Pharaoh Psammetichus (664-610 BC) on two newborn babies which were deprived of verbal contact in hope that they will develop their own, “primordial” language. In modern times, the acquisition of vocabulary has been studied in great detail, but surprisingly little attention has been paid to acquisition of more complex language comprehension abilities. In this study we assess 14 language comprehension abilities in 31,845 autistic individuals using parent-generated reports. Unsupervised hierarchical clustering identified three distinct language comprehension phenotypes: 1) individuals in the command language phenotype were limited to comprehension of their name and simple commands (40% participants); 2) individuals in the modifier language phenotype showed additional comprehension of color, size, and number modifiers (43%); and 3) individuals in the most-advanced prepositional language phenotype added comprehension of spatial prepositions, verb tenses, flexible syntax, possessive pronouns, and fairytales (17%). The three language comprehension phenotypes likely correspond to three distinct neurological mechanisms. Elucidation of these neurological mechanisms is important not only for developing better treatment options for individuals with language deficits, but also for understanding of language evolution in archaic humans, who may have acquired language comprehension in a similar three-step-wise fashion.
Studies on the disease resistance of rice restorer lines with PI9 blast resistance gene produced by dominant genic male sterile
Authors: Jiang Jianhua , Dang Xiaojing , zhang ying , Wang Dezheng 
Published: December 2022

Abstract
Rice blast is one of the most serious fungal diseases of rice. The most effective strategy for the control of rice blast is to use resistant genes to breed resistant varieties. The resistance gene PI9 is the first clone of the broad-spectrum resistance gene to rice blast, which has high level resistance to the races of magnaporthe grisea in many countries and regions. In this study, a two-line restorer line R998 with high blast resistance, good grain quality and high combining ability was developed by crossing 08C453-1 with Yangdao 6. The near-isogenic lines library of dominant genic male sterile (GMS) was established by backcrossing the elite germplasm of two-line restorer lines with GMS materials, the male sterile plants were selected from the library and crossed with R998 to F2, then the excellent individual plants with comprehensive traits were selected. Identification and screening techniques of rice blast, such as molecular assistant screening, artificial inoculation and induced selection of disease areas, were used, six restorer lines derived from R998 resistant to rice blast, R1501, anxiang 15, R1032, R1392, R7766 and R8917, were developed. The results showed that 71.5% of R998 and its six derived two-line restorers were moderately resistant. In addition, 9 medium indica varieties were bred by R998 and its 6 derived restorer lines, including 3 in China and 6 in province. Among them, Moliangyou 1501 composite index was 3.5 grade, the highest loss rate was 2.3 grade, and other varieties composite index was 4.1–5.5 grade, which was 1–3 grade higher than the control, the highest loss rate of other varieties was between 4.5–5.5 except for 7.0 in haoliangyou 729, which was 2–4 lower than the control. This study provides an idea for group breeding using dominant genic male sterile polymerized favorable genes.