bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding, Status, and Therapeutic Potentials of Stem Cells in Goat
Authors: Sharma Paramjeet , Sharma Neelesh , Choudhary Shanti , Luhach Priyanka , Choudhary Ratan K. 
Published: November 2022

Abstract:
The utility of animal stem cells finds implications in enhancing milk, meat, and fiber production
and serving animal models for human diseases. Stem cells are involved in tissue development,
growth, and repair, and in regenerative therapy. Caprine embryonic stem cells (ESCs), induced pluripotent
stem cells (iPSCs) and other tissue-specific adult stem cells (ASCs) have tremendous potential for
their use in regenerative medicine. The application of goat ESCs, iPSCs, mammary stem cells (MaSC),
mesenchymal stem cells (MSCs), spermatogonial stem cells (SSCs) and others can find their implication
in increasing caprine production potential and human disease model. The onset of the disease and therapeutic
effects of stem cells of many human diseases like sub-fertility, joint conditions, intervertebral disc
defects, osteoarthritis, and chondrogenesis can be well studied in goats. Increasing evidence of MSCs and
their secreted factors have drawn the attention of animal scientists in regenerative medicine. This review
summarizes a comprehensive overview of research made on caprine stem cells and illustrates some potential
applications of stem cells in caprine regenerative medicine and their utility as a model animal in understanding
human diseases.
Novel 1,4-Dihydropyrido[2,3-B]Pyrazine-2,3-Dione Derivatives for Treating Cancer
and Other Disorders Associated with KRAS Activity
Authors: De Surya K. 
Published: November 2022

Abstract:
This application describes the synthesis of new 1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione derivatives and methods of using these compounds as KRAS covalent inhibitors. This class of compounds is useful for treating cancer and other diseases associated with KRAS activity.
Prevalence of Functional Alterations and the Effects of Thyroid
Autoimmunity on the Levels of TSH in an Urban Population of Colombia:
A Population-Based Study
Authors: Vargas-Uricoechea Hernando , Agredo-Delgado Valentina , Vargas-Sierra Hernando David , Pinzón-Fernández María V. 
Published: November 2022

Background:
The population prevalence of functional alterations and thyroid autoimmunity is high, and numerous genetic and environmental aspects have been described as triggering factors.

Objectives:
The objective of this study was to determine the prevalence of functional alterations and thyroid autoimmunity in an urban population of Colombia.

Materials and methods:
It is a cross-sectional, population-based study (n= 9,638) conducted on an urban population of Popayán-Cauca-Colombia between February 5th, 2018, to December 11th, 2021. The variables evaluated were thyrotropin (TSH), free T4 (FT4), and anti-thyroid antibodies (thyroid peroxidase antibodies: TPOAb, and thyroglobulin antibodies: TgAb).

Results:
TSH in men was significantly higher than in women. No differences were observed in the
values of FT4, TPOAb, and TgAb (according to sex). The prevalence of normal thyroid function and
subclinical hypothyroidism was significantly higher in men. The positivity of TPOAb and TgAb was
22.3% and 19.2%, respectively. TSH levels increased with age (both in men and in women). In
participants with normal FT4 and negative TPOAb, the TSH was significantly higher. TSH was
significantly higher in TPOAb-positive individuals and among those with TPOAb and TgAb positives,
as well as in women with positive TPOAb and men with positive TPOAb and TgAb.

Conclusion:
In an urban population of Colombia, TSH was found to be higher than in populations of other geographical areas, especially in older individuals and in the presence of positive anti-thyroid antibodies, a high prevalence of functional alterations and thyroid autoimmunity was also found. These findings can be explained by excess iodine consumption and some environmental factors.
Teaching According to the Competency-based at Technical Pedagogical Universities
Authors: Cao Chinh Danh , Vu Hang Thi Thuy , Nguyen Thanh Thi , Nguyen Hung Thanh 
Published: November 2022

Background:
Six basic characteristics of competency-based teaching are: (1) teaching is conducted based on performance and individual needs; (2) the process can provide immediate learner feedback; (3) performance competencies are determined based on work analysis; (4) the program contains measurable goals and (6) uses performance standards as a reference for performance evaluation.

Objective:
This study is conducted to investigate the training quality of Technical Pedagogical University according to competency-based teaching.

Methods:
This study uses a quantitative approach, a survey of 54 school administrators and 186 lecturers from Technical Pedagogical University and 43 school administrators from Vocational Schools in Vietnam.

Results:
The main findings of the current study are (i) the training quality at Technical Pedagogical University that school administrators and lecturers from Technical Pedagogical University reported was relatively high; (ii) the levels of satisfaction with task requirements at Technical Pedagogical University reported by school administrators at vocational schools were relatively high.

Conclusion:
Although the evaluation from school administrators and lecturers from the two institutes is quite high, educators should focus on diversified and effective methods to enhance the quality of teaching in educational settings, especially competency-based teaching in universities.
Effectiveness of an Interprofessional Program (Siscare) for Supporting Patients With Type 2 Diabetes
Authors: Bawab Noura , Schneider Marie-Paule , Ballabeni Pierluigi , Locatelli Isabella , Bugnon Olivier , Perraudin Clémence 
Published: November 2022

ObjectiveTo assess the effectiveness of an interprofessional support program (Siscare) that includes motivational interviews (patient-pharmacist), electronic monitoring (EM) of medications, patient-reported and clinical outcomes monitoring, and interactions with physicians for patients with type 2 diabetes in French-speaking Switzerland.MethodsThis was a prospective, multicenter, observational cohort study using a hybrid implementation-effectiveness design. Individual daily adherence to at least one oral antidiabetic medication was measured by EM. A global adherence score was estimated by the product of a model-estimated implementation and a nonparametric estimate of persistence over time. Clinical outcomes (A1C, blood glucose, BMI, blood pressure, heart rate, and cholesterol levels) and quality of life (QoL) were analyzed over time using linear mixed-effect models.ResultsA total of 212 patients were included from 27 pharmacies; 120 patients (57%) were followed up for at least 15 months. In total, 140 patients (66%) were male, the mean age was 64 ± 11 years, and the mean number of chronic medications per patient at baseline was 5 ± 3. Of 178 patients who used EM, 95% (95% CI 92–99%) remained persistent at the end of the follow-up period. The percentage of persistent patients taking their medications appropriately (implementation) was stable during follow-up and was estimated to be 90% (95% CI 87–92%) at baseline and 88% (95% CI 84–91%) at month 15. At baseline, the mean A1C and BMI were 7.5% and 31 kg/m2, respectively, which decreased by 0.5% (P = 0.012) and 0.6 kg/m2 (P = 0.017), respectively, after 15 months. QoL remained stable during follow-up.ConclusionThe program supports medication adherence and improves clinical outcomes, illustrating the overall preventive effect of coordinated care.
Subtherapeutic levels of cefuroxime inside a cannulated pedicle screw used in spine surgery: results from a porcine microdialysis study
Authors: Hvistendahl Magnus A , Hanberg Pelle , Stilling Maiken , Kaspersen Alexander Emil , Høy Kristian , Bue Mats 
Published: November 2022

Background and purpose: Minimally invasive spine surgery has continuously evolved for specific surgical procedures and patient populations to lower morbidity and the risk of postoperative bacterial infection. Perioperative antibiotic prophylaxis is an important preventive measure and local tissue concentrations can be quantified with microdialysis. Insertion of spinal implants induces tissue trauma and inflammation, which may affect antibiotic proximate implant concentrations. We compared perioperative cefuroxime concentrations inside a cannulated pedicle screw used in minimally invasive spine surgery with the opposite non-instrumented vertebral pedicle.Materials and methods: Microdialysis catheters were placed inside a cannulated pedicle screw and in the opposite non-instrumented vertebral pedicle of the same vertebra (L1) in 8 female pigs through a posterior lumbar surgical approach. Following a single-dose intravenous cefuroxime administration (1.5 g), dialysates and plasma were dynamically sampled over 8 hours. The primary endpoint was time above the cefuroxime clinical breakpoint minimal inhibitory concentration for Staphylococcus aureus of 4 μg/mL (T>MIC4).Results: Median T>MIC4 was 0 h (range 0–0) inside the cannulated pedicle screw, 1.6 h (range 1.1–2.4) in non-instrumented vertebral pedicle, and 1.9 h (range 1.9–2.9) in plasma.Conclusion: A single-dose intravenous cefuroxime administration provided low and subtherapeutic concentrations for prevention of infection inside a cannulated pedicle screw in the lumbar spine. Therapeutic concentrations were achieved in the opposite non-instrumented vertebral pedicle up to 1.5–2 h. Therefore, additional prophylactic strategies may be considered in cannulated instrumented spine surgery, especially in high-risk patients. Alternative dosing regimens seem relevant in lumbar spine surgery lasting longer than 1.5 h.
The Effect of Different Intermediary Layer Materials Under Resin Composite Restorations on Volumetric Cuspal Deflection, Gap Formation, and Fracture Strength
Authors: Deger C , Özduman ZC , Oglakci B , Eliguzeloglu Dalkilic E 
Published: November 2022

SUMMARY
This study investigated the effect of different intermediary layer materials under class II mesio-occluso-distal (MOD) resin composite restorations on volumetric cuspal deflection, gap formation, and fracture strength. In total, 32 sound human maxillary premolars were used. After large, standardized Class II MOD cavities were prepared, a universal adhesive (Clearfil Universal Bond Quick, Kuraray) was applied. The premolars were randomly allocated into four groups according to different intermediary layer materials (n=8): Group Z250 (control)/micro-hybrid composite (Filtek Z250, 3M ESPE); Group EST/low-viscosity bulk-fill resin composite (Estelite Bulk Fill Flow, Tokuyama Dental Corp) + micro-hybrid composite; Group NOV/nanofiber-reinforced low-viscosity composite (NovaPro Flow, Nanova) + micro-hybrid composite; and Group RIB/polyethylene fiber [Ribbond, Ribbond Inc] + micro-hybrid composite. Distilled water was used for storage for 24 hours. Using microcomputed tomography (micro-CT), the teeth were scanned immediately after cavity preparation (T0), then 24 hours after restorative procedures (T1). Volumetric cuspal deflection in cubic millimeters (mm3) was analyzed on the palatal and buccal regions of each restoration individually at T0 and T1 scans. Gap formation (mm3) was evaluated to quantify the volume of black spaces at the tooth-resin interface on the T1 scan. After these scans, using a universal testing machine, the teeth were subjected to a fracture strength test (0.5 millimeters/minute [mm/min]). The fracture surfaces were analyzed with a stereomicroscope. The data were analyzed using the Kruskal-Wallis, one-way analysis of variance (ANOVA), and Dunn’s tests (p&lt; 0.05). No significant differences in volumetric cuspal deflection and fracture strength were detected for all tested groups (p&gt;0.05). Group RIB exhibited significantly higher gap formation values in comparison with all other groups (p&lt;0.05). Predominant failure mode was favorable.
PENINGKATAN KETERAMPILAN IBU PKK MELALUI PELATIHAN PEMBUATAN SABUN CUCI CAIR DAN SABUN MINYAK JELANTAH
Authors: Setiawati Ina , Widiantie Rahma , Hindiana Anna Fitri 
Published: November 2022

Desa Tarikolot merupakan sebuah desa yang berada di daerah perbatasan kabupaten kuningan dengan kabupaten Cirebon. Sebagian besar masyarakat memiliki keterampilan membuat alat-alat kebersihan seperti sapu, sikat, keset dll, sehingga desa tarikolot mendapat julukan desa penghasil alat-alat kebersihan. Perlu adanya peningkatan keterampilan selain membuat sapu, salahsatunya adalah keteampilan membuat sabun pencuci piring bagi ibu ibu PKK di desa Tarikolot agar membantu membuat peluang usaha baru dan meningkatkan pendapatan keluarga. Metode pelaksanaan kegiatan pengabdian masyarakat yang dilakukan meliputi 3 tahapan dianataranya; persiapan, pelaksanaan, evaluasi. Kegiatan persiapan diawali dengan; observasi ke desa tarikolot dan melakukan percobaan sederhana membuat sabun dengan melibatkan mahsiswa. Kegiatan pelaksanaan yaitu dengan melakukan penyuluhan pembuatan sabun pada ibu ibu PKK, serta melakukan sosialisasi produk sabun yang sudah dibuat kepada warga-warga desa tarikolot. Kegiatan evaluasi dilakukan dengan memberikan angket kepada ibu-ibu PKK yang sudah mendapatkan pelatihan. Manfaat dari kegiatan pengabdian masyarakat ini adalah masyarakat diharapkan ibu ibu PKK memiliki keterampilan membuat sabun serta membuka peluang usaha baru yang dapat menambah pendapatan keluarga.
“Algo como un sí, o un siempre y un ahora”. Tópicos del habeas vox en la palabra política de Cortázar sobre la desaparición de personas
Authors: Gómez Susana 
Published: November 2022

Este trabajo presenta algunas reflexiones en relación con los discursos de Cortázar en defensa de los derechos humanos en Argentina durante el período de la última dictadura cívico-militar. Se analiza cómo Cortázar habla como un escritor exiliado cuya palabra ya es considerada como autorizada para hablar de la desaparición forzada de personas por motivos políticos. El análisis de los discursos pronunciados ese año emblemático de 1981 es posible con apoyo en las nociones de habeas corpus y de habeas vox, útiles para dar a conocer el esfuerzo del escritor –en sucesivos foros internacionales– por crear un discurso creíble en relación con el horror de los desaparecidos.
Surface Treatments of Natural Fibres in Fibre Reinforced Composites: A Review
Authors: Seisa Keolebogile , Chinnasamy Vivekanandhan , Ude Albert U. 
Published: November 2022

Abstract
The use of natural fibres in fibre-reinforced composites comes with drawbacks. They are highly hydrophilic, leading to high moisture absorption and poor interfacial adhesion in matrix-reinforcement bonds. This affects the fibres’ thermal stability as well as mechanical properties, hence limiting their wider application. This paper reviewed different ways in which natural fibres have been treated to improve hydrophobicity, reinforcement-matrix interfacial adhesion and thermal stability. It will investigate. among others, treatments like alkali, acetylation, bleaching, silane, benzoylation and plasma, which have been found to improve fibre hydrophobicity. The literature reviewed showed that these methods work to improve mechanical, chemical, and morphological properties of natural fibres by removing the amorphous surface, thus allowing for more efficient load transfer on the fibre-matrix surface. Studies in the literature found alkali treatment to be the most common surface modification treatment due to its simplicity and effectiveness. However, plasma treatment has emerged due to its lower processing time and chemical consumption. A comparative analysis of other improved properties was also investigated.
Removal of Heavy Metals from Aqueous Solutions with the Use of Lignins and Biomass
Authors: Miros-Kudra Patrycja , Sobczak Paulina , Kopania Ewa 
Published: November 2022

Abstract
The overproduction of pollutants resulting from the development of industry causes the deposition of large amounts of toxic and carcinogenic substances, including heavy metals, in the aquatic ecosystem and other ecosystems. This is a civilisation problem of the present times, posing a serious threat to the natural environment, including humans. For this reason, it has recently become extremely important to develop effective methods to minimise the concentration of heavy metal ions in the aquatic systems and thus reduce their negative impact on the environment. One such technique is adsorption, which is believed to be an effective method of removing contaminants such as heavy metal ions from aqueous solutions. Looking at the available literature of the last few years, it can be concluded that adsorbents of natural origin are becoming more and more important. These are agricultural waste, all kinds of biomass, and waste from various industries. The study attempts to present and evaluate the sorption capacity of materials of natural origin, including oat bran, chitosan, alginate, tree bark, coconut fibre, and lignin. The use of such biosorbents is more friendly for the environment compared to their synthetic counterparts and perfectly fits the concept of sustainable development and the circular economy.
Artificial Neural Network-based Prediction Technique for Waterproofness of Seams Obtained by Using Fusible Threads
Authors: Karabay Gulseren , Senol Yavuz , Ozturk Hasan , Mesegul Cansu 
Published: November 2022

Abstract
The aim of this study was to estimate waterproofness values of seams composed of the combination of fusible threads and antiwick sewing threads through artificial neural networks (ANN). Fusible threads were used to obtain waterproof seams for the first time. Therefore, estimating the value of the waterproofness variable with the help of models created from test values can contribute to accelerating the progress of further studies. Hence, ten different samples were prepared for two fabrics, and the waterproofness values of the seams obtained were tested using a Textest FX 3000 Hydrostatic Head Tester III. For the prediction of waterproofness values of the seams, the Levenberg-Marquardt backpropagation algorithm was used for artificial neural network pattern models with sigmoid and positive linear transfer functions. Finally, the ANN model was successful in estimating the waterproofness of the seams. The highest correlation coefficient was R = 0.95081 which indicated that the prediction made by the neural network model proved to be reliable.
Coefficients for Assessing the Visibility of Materials Used in Anti-Smog Face Masks
Authors: Brochocka Agnieszka , Owczarek Grzegorz , Szkudlarek Joanna 
Published: November 2022

Abstract
The application of phosphorescence for the modification of face mask materials is motivated by the need to appreciably increase their visibility while using graphical elements with a relatively small area. Phosphorescent dyes absorb part of the visible spectrum while emitting radiation at wavelengths that are longer than the absorbed ones. Thus, a phosphorescent substance can emit light even if it is not being illuminated at a given time (but was before). This paper describes studies of the optical properties based on parameters such as the reflectance coefficient, chromaticity coordinates, as well as luminance measured from digital images for two models of smog-protective face half-masks differing in terms of their inner layer with filtration properties and outer printed layer. The external surface of one mask type is printed with a phosphorescent solid star pattern, while the other with a phosphorescent open star pattern. The influence of the inner filter layer was assessed in correlation with the colour of the outer layer and the type of printing. Moreover, the phenomenon of phosphorescence was identified. The study resulted in developing a material with properties providing better visibility under defined use conditions.
Influence of the Structure of Low MolecularWeight Esters on Poly(lactic acid) in the Plasticization Process - part 1
Authors: Gzyra-Jagieła Karolina , Sulak Konrad , Draczyński Zbigniew , Kiełbik Longina Madej , Jagodzińska Sylwia , Borkowski Dominik 
Published: November 2022

Abstract
Polymers derived from renewable sources which are additionally subject to degradation processes are currently an interesting alternative to conventional polymers of petrochemical origin. One of such polymers is poly(lactic acid) (PLA), which can be used in the packaging, textile and also medical industries. Its great advantage is the susceptibility to biodegradation and the nontoxicity of the degradation products. Because of high brittleness and stiffness, the modification of PLA is necessary to improve its plastic deformability, which can expand the new application possibilities. As part of the research work, the modification of PLA by plasticisation was undertaken to improve its plastic deformability properties. The low molecular mass esters from the citrate group and glycerol triacetate were used. The samples extruded from plasticised polymer were characterised using Differential Scanning Calorimetry (DSC) and Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC). The mechanical properties and melt flow rate after modification were determined. The aim of the research was to determine the relationship between the structure of a plasticiser and its ability to reduce the interactions in the polymer chain in order to develop an optimal polymer-plasticiser arrangement. Based on this research, there was no relationship between the efficiency of the plasticisation process and the increasing molecular mass of the plasticiser. The additional chemical (acetyl) group in the plasticiser also does not increase the efficiency of the PLA plasticisation process. In the next steps of the research, functional forms will be produced, i.e. fibers, films, and fittings from the selected polymer-plasticiser systems.
Vietnam’s Commitments Under the European Union – Vietnam Investment Protection Agreement (EVIPA): Some Noteworthy Points
Authors: Binh Ha Thi Thanh 
Published: November 2022

Abstract
The Investment Protection Agreement among Vietnam, the European Union (EU) and each of the EU’s member states (EVIPA) was signed by Vietnam and the EU on June 30, 2019, in Ha Noi. While the Free Trade Agreement between Vietnam and the EU (EVFTA) promotes trade liberalization between Vietnam and EU countries, EVIPA establishes legal safeguards for outward investment activities of investors from EU countries into Vietnam and vice versa. The EVIPA has not yet come into effect as it needs to be approved not only by the EU Council and the National Assembly of Vietnam, but also by the Parliaments of all EU’s member states. Even so, with the EVFTA in place, Vietnam hopes to attract more investment from the EU as Vietnam has committed to provide investors from the EU with certain protection some of which have not been available in any other investment protection agreements to which Vietnam is a party. Investors with EU nationalities undoubtedly are interested in how Vietnam could implement its commitments under the EVIPA. The paper discusses key commitments of Vietnam under the EVIPA along the lines of relevant provisions of Vietnam law and addresses some noteworthy points for investors from the EU planning to invest in Vietnam. It argues that understanding how domestic law and regulations facilitate international commitments would help investors from the EU prepare for their investments in Vietnam.