bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Therapy with Gemcitabine and Stereotactic Body Radiation Therapy Versus Gemcitabine Alone for Resected Stage II Pancreatic Cancer: A Prospective, Randomized, Open-label, Single Center Trial
Authors: Ma Tao , Bai Xueli , Wei Qichun , Shui Yongjie , Lao Mengyi , Chen Wen , Huang Bingfeng , Que Risheng , Gao Shunliang , Zhang Yun , Chen Wei , Wang Ji , Liang Tingbo 
Published: April 2022

Abstract
Background: The role of adjuvant radiation in pancreatic adenocarcinoma (PDAC) remains unclear. We aimed to investigate the efficacy of gemcitabine combined with stereotactic body radiation therapy (SBRT) as adjuvant therapy for resected stage II PDAC.Methods: In this single center randomized controlled trial, patients with stage II PDAC that underwent margin-negative resection were randomly assigned to gemcitabine-alone adjuvant chemotherapy or adjuvant SBRT followed by gemcitabine chemotherapy. The primary endpoint was recurrence-free survival (RFS). Secondary endpoints included locoregional recurrence-free survival (LRFS), overall survival (OS), and incidence of adverse events. Results: Forty patients were randomly assigned to treatment between Sep 1, 2015 and Mar 31, 2018. Of these, 38 were included in the intention-to-treat analysis (20 in gemcitabine arm and 18 in gemcitabine plus SBRT arm). The median RFS and OS were 9.70, 28.0 months in the gemcitabine arm and 5.30, 15.0 months in the gemcitabine plus SBRT arm (RFS, P = 0.53; OS, P = 0.20), respectively. The median LRFS in both arms was unreached (P = 0.81). Grade 3 or 4 adverse events were all comparable between the two arms. Evaluation of data from the first 40 enrolled patients indicated that the addition of adjuvant SBRT was not associated with either better local disease control or recurrence free survival. Conclusions: Adjuvant SBRT neither provided a survival benefit nor improved local disease control in resected stage II PDAC. Trial registration: ClinicalTrials.gov NCT02461836
Calcium intake is not associated with kidney stone: Findings From the 2015 to 2018 National Health and Nutrition Examination Survey (NHANES)
Authors: Wei Linna , Wang Xin , Zou Xiangyi , Ma Lexin , He Jinshen 
Published: April 2022

Abstract
Kidney stone is a common disease nowadays, whose main component is calcium oxalate. A large amount of people eagerly to supply calcium from the dietary food, however, they are still afraid of kidney stone. In addition, some patients with kidney stones are suggested to decrease the calcium intake but there are newly search which recommends to not cut down it. We wondered whether the kidney stones are associated with calcium intake in daily life. This study investigates the relation between calcium intake and kidney stone. We supposed that the calcium intake is linked to kidney stone. People, who participated in the NHANES, from 2015 to 2018, were included and they were screened by the constraints. Multi-variable logistic regression was used to assess the association between calcium intake and kidney stone, adjusting for other confounding factors. At the same time, to conduct stratification studies, we took calcium intake as a continuous variable and classification variables respectively. In the muti-variate analysis, calcium in food had no connection with kidney stone([odds ratio] 0.9999, [confidence interval] 0.9998-1.001 in model 3 which is fully adjusted. During the trend test, there was no prominent difference from calcium quality from Q1 to Q4 in those 3 models and the muti-variate analysis separated by confounding factors might affect the result according to the univariate analysis, we found there was no disparity. So, we conclude that having the history of kidney stone is no connection with calcium intake.
Physical activity during pregnancy: a review of evidence-based recommendations
Authors: Budler Leona Cilar , Budler Marko 
Published: April 2022

Abstract
Background: Physical activity, as a key part of healthy lifestyle, is essential to maternal and infant health. Healthcare workers should inform pregnant women about benefits of physical activity to prevent possible health issues. Those recommendations should elaborate on relevant contemporary evidence. The aim of this paper was to review evidence-based recommendations for physical activity during pregnancy.Methods: A systematic search, analysis and synthesis of conducted randomised controlled trials (RCTs) was conducted from October 2021 to February 2022 in following databases: CINAHL, ScienceDirect and Web of Science. Literature was searched using inclusion and exclusion criteria and following PRISMA recommendations. Results: Benefits for pregnant-women health and well-being were reported while performing aerobic exercise, lumbar stabilization and stretching exercise, water exercise, nerve and tendon-slip exercise, resistance training and strength training. For all exercise modalities it is recommended to perform moderate intensity activities during the whole time of pregnancy.Conclusions: This systematic literature review supplements current knowledge on physical activity of pregnant women. It is believed that physical activity has many positive outcomes on maternal and infant health. Thus, interventions in terms of exercise prescriptions are listed and suggested in an integrative model to contextualize and promote physical activity among pregnant women.
Airport Terminal Area Capacity Calculation Based on Supply and Demand Balance of Service Resources
Authors: 牟 奇锋 , Zhang Liming , Fang Ce , Li mingjie , feng xiaolei 
Published: April 2022

Abstract
To effectively predict the hourly capacity of the airport terminal area, i.e., to measure the maximum number of aircraft that can receive air traffic services in a sector simultaneously under the condition that the capacity is known, this study proposes a model to calculate the terminal area capacity based on the perspective of service resources. Firstly, the supply and demand relationship between the terminal area capacity and service resource consumption was analyzed based on the configuration of the terminal area route network, traffic flow characteristics and airspace safety, and security capacity requirements. Secondly, by defining a flight service probability matrix, a demand service time model and a maximum available service time model for the terminal area were developed. Based on the balance between the supply and demand of service resources, a model was constructed to forecast the capacity of the terminal area. Finally, the validity of the model was verified by simulation. The example results indicated that the difference between the limit and correction capacities obtained from the model calculations and the simulation results is lesser than 0.3 vehicles/hour. Both the results are consistent with the actual operation, thus proving the validity and reliability of the calculation model used in this study. It was also found that when the capacity is known, the model can calculate the maximum number of aircraft receiving services simultaneously within the terminal area at peak times. These findings suggest that the proposed model can provide a theoretical basis and reference for terminal area sectoring and traffic alerting.
Body Shape and Risk of Glaucoma: A Mendelian Randomization
Authors: Yuan Ruolan , Liu Kangcheng , Cai Yingjun , He Fei , Zou Jing 
Published: April 2022

Abstract
Background: Several observational studies have revealed a positive or negative correlation between body size (BS) and glaucoma. However, the effect of BS on glaucoma remains unclear. Therefore, we studied BS causal association with glaucoma risk using Mendelian randomization (MR).Method: The Body Size was determined through anthropometric traits (ATs), such as body mass index (BMI), waist-to-hip ratio adjusted by body mass index (WHRadjBMI), waist-to-hip ratio (WHR), and waist circumference (WC). Association of single nucleotide polymorphisms (SNPs) with each AT and glaucoma were determined individually from the aggregated data of the Genetic Investigation of Anthropometric Traits (GIANT) consortium and the FinnGen study summary data (8591 cases with glaucoma and 210,201 controls). To explore the role of BS and glaucoma, a two-sample MR analysis was performed on genome-wide association study (GWAS) data. Besides, three MR methods (inverse variance weighted [IVW], weighted median, and MR-Egger regression) were used to get the whole causal estimate for multiple instrumental SNPs.Results: The odds ratio (OR) [95%confidence interval (CI)] for glaucoma risk per 1-SD difference in BMI (OR = 1.20; 95%CI = 1.02-1.41; P = 0.03[P＞0.05/64]) was detected. However, no significant heterogeneity was observed between SNPs. Overall causal estimates were consistent between BMI and glaucoma in other two MR methods. Besides, genetically predicted WHRadjBMI (OR = 1.10; 95%CI = 0.85-1.40; P = 0.50), WHR (OR = 1.22;95%CI =0.91-1.62; P = 0.18), and WC (OR = 1.32;95%CI =1.04-1.69; P = 0.03[P＞0.05/36]) were not associated with glaucoma. Besides, sensitivity analysis did not find any other directional pleiotropy. Conclusion: The data of this study revealed that the BS, including BMI, WHR, WHRadjBMI, and WC, was not the risk factor for glaucoma.
Predictive value of the indicators of lateral and medial knee morphology for total knee arthroplasty in patients with varus knee osteoarthritis
Authors: Ma Wenru , Li Chunpu , Liu Guangzhen , Sun Shengnan , Shen Youliang , Yu Tengbo , Zhang Yi 
Published: April 2022

Abstract
PurposeThis study aimed to establish a predictive model to aid in patient selection and decision-making efforts regarding total knee arthroplasty (TKA).MethodsUsing data collected from our retrospective TKA database, 132 patients with varus knee osteoarthritis (153 knees) were included in the study. We focused on patients with a diagnosis of Kellgren–Lawrence (K-L) grade II in the initial stage of knee osteoarthritis (OA) and K-L grade IV with TKA at the endpoint. The interval between baseline and endpoint was defined as the remaining life of the knee joint. The following lateral and medial knee indicators were assessed using standard anteroposterior (AP) and lateral radiography: fibula height (FH), lateral plateau widening (LPW), medial proximal tibial angle (MPTA), and joint line convergence angle (JLCA) at baseline (FH0, LPW0, MPTA0, and JLCA0, respectively); FH, LPW, MPTA, and JLCA in the TKA period (FHT, LPWT, MPTAT, and JLCAT, respectively); changes in FH, LPW, MPTA, and JLCA between baseline and TKA periods (cFH, cLPW, cMPTA, and cJLCA, respectively); and rates of change in FH, LPW, MPTA, and JLCA between baseline and TKA periods (ΔFH, ΔLPW, ΔMPTA, and ΔJLCA, respectively). Multivariate linear regression analysis was performed for comparisons of indicators with the remaining life of the knee joint.ResultsRates of change in FH and LPW between baseline and TKA periods were negatively correlated with the remaining life of the knee joint (ΔFH, β = −335.901, t = −2.182, P = 0.035; ΔLPW, β = −488.516, t = −2.588, P = 0.013). There were positive correlations of ΔMPTA and ΔJLCA with risk of requiring TKA, respectively (r = −0.523 and − 0.480, respectively, all P < 0.001), but these correlations were not statistically significant in the predictive model of the remaining life of the knee joint. Other indicators were not significantly correlated with the remaining life of the knee joint (all P > 0.05).ConclusionsRates of change in FH and LPW robustly predict the risk of requiring TKA.Level of Evidence: Retrospective Study Level III
Anti-inflammatory and wound healing activity of methanol extracts of Azadirachta indica A. Juss, Lawosinia inermis L and Achyranthus aspera L in in vitro models
Authors: Nigussie Dereje , Davey Professor Gail , Legesse Belete Adefris , Fekadu Abebaw , Mekonnen Eyasu 
Published: April 2022

Abstract
Background
Lymphoedema is a pathological process that results from damage, infection, blockage, or genetic defects in the lymphatic system. The main causes of lower limb lymphoedema in Ethiopia are lymphatic filariasis (LF) and podoconiosis. Many natural products are being used for management of wound and inflammatory conditions in Ethiopia. Few of these products have been systematically evaluated using in vitro tests.
Objective
The objective of this study was to conduct in vitro cytotoxicity assays, anti-inflammatory, and wound healing activity tests on selected Ethiopian plant extracts.
Methods
The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate cytotoxicity of the plant extracts. For the anti-inflammatory activity, cyclooxygenase enzymes 1 (COX-1), cyclooxygenase enzymes 2 (COX-2) and 15-lipoxygenase enzyme inhibitory assay was used. Antioxidant activities were conducted using DPPH assay. Quantification of cell multiplication based on the measurement of BrdU incorporation during deoxyribonucleic acid (DNA) synthesis, was used to measure deoxyribonucleic acid (DNA) /cell proliferation.
Results
Azadirachta indica A. Juss (82%) and Lawosinia inermis L (87.6%) showed significant inhibition against COX-1 at 25 mg/ml, while Achyranthus aspera L (91.7%) and A. indica (95%) were effective in inhibiting COX-2 at the same concentration. Similarly, L. inermis L inhibited 88.8% of COX-2 at the same concentration. L. inermis (74.8%) showed the highest inhibitory activity against 15-LOX, followed by A. asper (73.1%) and A. indica (66%) at 25mg/ml. All the tested extracts showed free radical scavenging activity at 10 mg/ml. A. indica and L. inerms have shown better stimulation of human epidermal keratinocytes, with optimal stimulation observed between 2.5 mg/ml and 5 mg/ml of the extracts.
Conclusion
Plant extracts or compounds that inhibited these enzymatic inflammatory activities may contain potential drivers or templates for the development of effective anti-inflammatory drugs. Antioxidants that maintain non-toxic ROS levels in wound tissue can improve the wound healing process.
Predefined-Time Anti-Saturation Fault-Tolerant Attitude Control for Tailless Aircraft with Guaranteed Output Constraints
Authors: yu zhiong , Li Yinghui , lv maolong , Chang Jing , pei binbin 
Published: April 2022

Abstract
This work investigates the anti-saturation attitude tracking control for the tailless aircraft with guaranteed output constraints, in presence of uncertain inertia parameters, bounded external disturbance, and actuator faults/failures. A predefined-time adaptive backstepping attitude control scheme has been proposed, the main features of this scheme lie in (a) designing a predefined-time filter to deal with the `explosion of complexity' and singularity problem; (b) introducing a nonlinear state-dependent function to handle the asymmetric time-varying output constraints; (c) compensating for the impact of the actuator faults/failures and input saturation by a nonlinear function and bounded estimation simultaneously. Moreover, the proposed control scheme can ensure all signals in the closed-loop system converge to a residual set around the origin within a predefined time, and this time constant can be set freely by the designer, independently of initial conditions. Finally, numerical simulations have been conducted to verify the performance of the proposed predefined-time fault-tolerant control scheme.
Characteristic MRI findings of the shoulder, elbow, and wrist joints in elite wheelchair basketball players
Authors: Sakai Masafumi , Mutsuzaki Hirotaka , Shimizu Yukiyo , Okamoto Yoshikazu , Nakajima Takahito 
Published: April 2022

Abstract
Background
The health of wheelchair users’ upper limbs is directly related to their quality of life. In addition, para-sport athletes are subjected to a dual load on their upper extremities from competition and daily life, making it even more critical to maintain upper extremity health. This study aimed to investigate the characteristics of joint disorders in elite wheelchair basketball players using magnetic resonance imaging (MRI).
Methods
We scanned MRI images of the bilateral shoulders, elbows, and wrist joints of ten elite wheelchair basketball players and ten general wheelchair users. Two radiologists interpreted the MRI images and diagnosed the diseases of each joint. We compared the number of lesions between the two groups. We used Fisher's exact test to determine whether the lesions diagnosed by MRI were specific to wheelchair basketball players. The significance threshold was set at P < 0.05.
Results
Elite wheelchair basketball players had significantly more left-sided and bilateral latero-posterior lesions, which are cysts found on the lateral-posterior corner of the capitulum of the humerus than general wheelchair users (P < 0.05). Severe damage to the right triangular fibrocartilage complex was also observed more frequently (P < 0.05) in wheelchair basketball players.
Conclusions
We believe that the patient’s tendency to fall forward in the wheelchair hitting both hands on the ground, thereby injuring the triangular fibrocartilage complex and locking the lateral elbow, may be the cause of the characteristic findings on MRI. High-speed wheelchair operation was also thought to be a cause of severe triangular fibrocartilage complex injuries. Therefore, more attention should be paid to hand placement and wrist protection during falls. This study's insights can be useful for future solutions to extend players' careers.
Trial registration:
This paper is not a paper reporting the results of a medical intervention on human participants. That is, it is not a report of a clinical trial.
Impact of Chief Executive Officers (CEO) Duality on Financial Performance of Commercial Banks in Ethiopia
Authors: Gebrayes Workinesh Kebede , Edeit Addisu Gemeda 
Published: April 2022

Abstract
The main objective of this study is to examine the relationship between the Chief Executive Officer (CEO) duality and the financial performance of commercial banks in Ethiopia. 12 commercial banks are included in this study among 17 banks in Ethiopia based on their financial report of 10 years for the period of 2009 to 2018. Five banks have not been included in the sample selection since one bank is a development bank and the other four commercial banks are newly established. The secondary data have been accrued from the National Bank of Ethiopia with banks' financial performance and primary data have been gathered from selected commercial banks using survey questionnaires concerning corporate structure. It uses panel data on financial performance measured by Return on Equity (ROE), Return on Asset (ROA), and Net Interest Margin (NIM). To analyze data E-View 9 Statistics was used. Both multiple regression and correlation were used to determine the relationship between the Chief Executive Officers (CEO) duality and financial performance of commercial banks in Ethiopia. The study investigated that half of the banks chief executive officers hold the position of chairman The correlation result indicate that Chief Executive Officer (CEO) duality has a positively and statistically insignificant relationship with the financial performance of commercial banks as measured by Return on Equity (ROE) (0.013), there is a negative relationship between Chief Executive Officers (CEO) Duality (-0.231) and the financial performance as measured by Return on Assets (ROA). There is a negative relationship between Chief Executive Officer (CEO) duality (-0.043) and the financial performance as measured by Net Interest Margin (NIM).
Impact of APOE ε3 and ε4 genotypes on plasma proteome signatures in Alzheimer's disease
Authors: Kaur Gurjeet , Poljak Anne , Masters Colin L , Fowler Christopher , Sachdev Perminder 
Published: April 2022

Abstract
Background: The ε4 allele of the apolipoprotein E (APOE) gene is a high-risk factor for Alzheimer's disease (AD). However, approximately 25%–40% of patients with AD do not carry the APOEe4 allele, and the pathophysiological mechanisms underlying AD are less evident in these individuals. The main objective of this study was to understand the changes in plasma that may contribute to disease pathogenesis in AD and how APOEe3 and APOEe4 contribute to plasma biomarker profiles in AD.Methods: We conducted an in-depth plasma proteomics analysis using intensive depletion of high-abundant plasma proteins with Agilent multiple affinity removal liquid chromatography (LC) column- Human 14 (Hu14) followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS PAGE) technique coupled with Q-Exactive Plus mass spectrometer (Thermo Electron, Bremen, Germany). Two search engines were used to analyze the raw files, including ProteomeDiscoverer v2.4 (Thermo Fisher Scientific, Waltham, MA) and Scaffold Q+ software v 4.11.0 (Proteome Software, Portland).Results: In our study, we have expanded the depth of plasma proteome coverage to reveal new differentially expressed proteins (DEPs) that correlated with AD pathogensis. The identification of 134 proteins in AD APOEε3 relative to ε3 controls and 71 in AD APOEε4 relative to ε4 controls are reported in this study. Mainly signature proteins identified were associated with molecular functions including complement cascade, glycolysis, metabolism, plasma lipoprotein assembly, remodeling, and clearance. Here, we have shown a list of proteins such as MB, GPI and PKM reflecting the biochemical changes that are associated with pathogenesis of AD despite the APOE genotypes. The increase plasma proteome depth allowed us to identify a large number of proteins which are previously reported in brain tissue or cerebrospinal fluid in AD cohorts are likely much stronger candidates for future validation work.Conclusion: This study performed an in-depth proteome analysis to identify plasma proteome signatures associated with APOEε3 and APOEε4 genotypes. Further analysis of proteome correlation with APOE genotpyes will yield clinically meaningful information into the biological basis of AD.
Robot Grasping in Random Scenarios Based on hybrid optimization algorithm (MR-GPD)
Authors: Zhnag Songsong , huang Haisong 
Published: April 2022

Abstract
Robot grasping technology is favored by scientific researchers because of its importance in the field of robotics and its prospects. The main challenge of robotic grasping is to design an effective grasping detection algorithm for accurate grasping of the robot. Recently, various robotic grasping techniques have been proposed to improve the grasping performance of the robot. However, for random objects in an unstructured environment, even if accurate target classification is performed, multiple targets may overlap, which leads to a decline in the grasping performance of many robot grasping methods and cannot meet the accuracy requirements. To solve this problem, we propose an innovative grasping detection algorithm, which we call MR-GPD. MR-GPD is based on the robot grasping gesture detection algorithm (GPD), embeds the Mask-RCNN deep learning model to classify and segment the grasped target, then combine the results of target segmentation to construct a grasping candidate screening mechanism to evaluate and filter the outputted grasping candidates, and retain the best grasping candidate plan in the planned grasping task. To meet the requirements of the robots actual grasping task, an improved Mask-RCNN neural network model is proposed, the speed and accuracy of target segmentation in the actual grasping process of the robot are improved, and the accuracy of the model reaches 97.5%. In this article, we conducted experimental evaluations through experimental tests and Baxter robots. The experimental results show that the method has a good grasp effect on randomly placed objects in unstructured environment, and the average success rate is about 91.2%, it reveals the feasibility of our proposed MR-GPD method, which is expected to provide important information for robot grasping in unstructured environment.