bluuebunny/crossref_metadata_2025_split huggingface dataset:
An accurate genetic assay to identify human neutrophil antigen 2 deficiency
Authors: Li Yunfang , Schuller Randy M. , Wu Jianming 
Published: October 2022

AbstractObjectiveWe aimed to develop accurate and user‐friendly genetic assays to identify the inherited neutrophil antigen‐2 (HNA‐2) deficiency in humans.BackgroundHNA‐2 is one of the most important neutrophil antigens implicated in a number of human disorders. HNA‐2 deficiency or HNA‐2 null is a common phenotype observed in 3%–5% Americans. HNA‐2 null individuals are at risk to produce isoantibodies (or alloantibodies) that play important roles in transfusion‐related acute lung injury, immune neutropenia, and bone marrow graft failure. We previously demonstrated that the CD177 coding SNP 787A > T (c.787A > T) is the most important genetic determinant for HNA‐2 deficiency. However, reliable genetic assays are not available for routine clinical laboratory application up to now.Study Design and MethodsA novel polymerase chain reaction (PCR) strategy was used to determine genotypes of the CD177 SNP c.787A > T. In the simplified PCR assay, all allele specific primers and internal control primers were included in the same reaction, which ensures reliability of the assay. In addition, a novel high‐throughput nested TaqMan assay was developed to determine genotypes of c.787A > T for large population genetic analysis of HNA‐2 deficiency.ResultsCD177 SNP c787A > T genotypes of 396 subjects were 100% concordant among the single PCR reaction method, the nested TaqMan assay, and Sanger Sequencing analysis. Out of 396 subjects, all 18 donors with the CD177 STP homozygous genotype were HNA‐2 null.ConclusionThe novel PCR‐based genotyping assay is accurate to identify HNA‐2 deficient individuals and is suitable for clinical laboratories. In addition, the innovative high‐throughput nested TaqMan assay will be useful for large‐scale population screens and genetic studies of HNA‐2 deficiency.
Magnetic dipole moments as a strong signature for $$\alpha $$-clustering in even-even self-conjugate nuclei
Authors: Stellin Gianluca , Speidel Karl-Heinz , Meißner Ulf-G. 
Published: October 2022

AbstractWe investigate the magnetic dipole moments in even-even self-conjugate nuclei from$$^{12}$$12C to$$^{48}$$48Cr. For these nuclei, the measured gyromagnetic factors of excited states turn out to assume the same value of$$g \approx + 0.5$$g≈+0.5within statistical errors. This peculiar feature can be interpreted on the basis of collective excitations of$$\alpha $$α-clusters. Analogously, the behaviour of the same observable is studied for all isotopes obtained by adding one or two neutrons to the considered self-conjugate nuclei. It is found that for the$$N = Z + 1$$N=Z+1isotopes the$$\alpha $$α-cluster structure hardly contributes to the observed negative g- factor value, corroborating molecular$$\alpha $$α-cluster models. The addition of a further neutron, however, restores the original$$\alpha $$α-cluster g-factors, except for the semi-magic isotopes, in which the deviations from$$g \approx + 0.5$$g≈+0.5can be associated with the relevant shell closures. Secondly, we analyze the same observable in the framework of a macroscopic$$\alpha $$α-cluster model on a finite lattice of side lengthL. We focus on the discretization effects induced in the magnetic dipole moments of the$$2_1^+$$21+and the$$3_1^-$$31-states of$$^{12}$$12C at different values of the lattice spacinga.
Early time behavior of spatial and momentum anisotropies in kinetic theory across different Knudsen numbers
Authors: Borghini Nicolas , Borrell Marc , Roch Hendrik 
Published: October 2022

AbstractWe investigate the early time development of the anisotropic transverse flow and spatial eccentricities of a fireball with various particle-based transport approaches using a fixed initial condition. In numerical simulations ranging from the quasi-collisionless case to the hydrodynamic regime, we find that the onset of $$v_n$$

v
n

and of related measures of anisotropic flow can be described with a simple power-law ansatz, with an exponent that depends on the amount of rescatterings in the system. In the few-rescatterings regime we perform semi-analytical calculations, based on a systematic expansion in powers of time and the cross section, which can reproduce the numerical findings.
New physics in $$\text {b} \rightarrow \text {s}$$ transitions in the MF331 model
Authors: Duy N. T. , Thu P. N. , Huong D. T. 
Published: October 2022

AbstractThere are two sources that help to explain the $$\text {R}_\text {K}$$

R
K

, $$\text {R}_{\text {K}^*}$$

R

K
∗

anomalies in the MF331 model. The first is non-LFUV couplings of the new neutral gauge boson $$\text {Z}^{\prime }$$

Z
′

with leptons, $$\text {g}^{\text {Z}^\prime }(e)\ne \text {g}^{\text {Z}^\prime }(\mu ,\tau )$$

g

Z
′

(
e
)

≠

g

Z
′

(
μ
,
τ
)

, which causes the $$\text {R}_\text {K}$$

R
K

, $$\text {R}_{\text {K}^*}$$

R

K
∗

anomalies via $$\text {Z}^\prime $$

Z
′

-penguin diagrams involving newly charged gauge bosons $$\text {X}^{\pm }_{\mu }$$

X
μ
±

, and exotic U-quarks. The second is the contribution from the box diagram only for the first generation of leptons. We show that the penguin diagrams can not explain $$\text {R}_\text {K}$$

R
K

, $$\text {R}_{\text {K}^*}$$

R

K
∗

anomalies, and that the box diagram is required. The experimental constraints for $$\text {R}_\text {K}$$

R
K

and $$\text {R}_{\text {K}^*}$$

R

K
∗

result in new particle mass degeneracy. The contributions of NP to the branching ratios $$\text {Br}(\text {B}_{\text {s}}\rightarrow \mu ^+ \mu ^-), \text {Br}(\text {b}\rightarrow s \gamma )$$

Br

(

B
s

→

μ
+

μ
-

)

,
Br

(
b
→
s
γ
)

predict results that agree with the experimental limits in the allowed region of the NP scale.
Late-time-accelerated expansion esteemed from minisuperspace deformation
Authors: Tajahmad Behzad 
Published: October 2022

AbstractThe effects of minisuperspace deformation on Einstein–Hilbert action along with ordinary and phantom scalar fields as the matter contents are investigated. It is demonstrated that late-time-accelerated expansion and phase transition (from decelerated to accelerated) are obtained as a consequence of minisuperspace deformation. Finally, a mathematical theorem for distinguishing valid descriptions of the noncommutative frames is suggested.
The possibility of X(4014) as a $$D^*{\bar{D}}^*$$ molecular state
Authors: Duan Man-Yu , Chen Dian-Yong , Wang En 
Published: October 2022

AbstractWithin the framework of the local hidden gauge approach, we have studied the near-threshold $$D^* {\bar{D}}^*$$

D
∗

D

¯

∗

interaction with quantum numbers $$I(J^{PC}) = 0(0^{++})$$

I

(

J

PC

)

=
0

(

0

+
+

)

, $$0(2^{++})$$

0
(

2

+
+

)

, $$1(0^{++})$$

1
(

0

+
+

)

, and $$1(2^{++})$$

1
(

2

+
+

)

, respectively. The contact term and vector meson exchange term in coupled channels are taken into account in this work. One pole, which is found in the case of the quantum numbers $$I(J^{PC}) = 0(0^{++})$$

I

(

J

PC

)

=
0

(

0

+
+

)

, could be associated to the X(4014) recently observed by the Belle Collaboration. Thus, we suggest that the X(4014) may be an $$D^* {\bar{D}}^*$$

D
∗

D

¯

∗

molecular state with $$I(J^{PC}) = 0(0^{++})$$

I

(

J

PC

)

=
0

(

0

+
+

)

, and more precise information about X(4014), such as resonance parameters and decay properties, could be useful to shed light on its structure.
Simulator-based Explanation and Debugging of Hazard-triggering Events in DNN-based Safety-critical Systems
Authors: Fahmy Hazem , Pastore Fabrizio , Briand Lionel , Stifter Thomas 
Published: October 2022

When Deep Neural Networks (DNNs) are used in safety-critical systems, engineers should determine the safety risks associated with failures (i.e., erroneous outputs) observed during testing. For DNNs processing images, engineers visually inspect all failure-inducing images to determine common characteristics among them. Such characteristics correspond to hazard-triggering events (e.g., low illumination) that are essential inputs for safety analysis. Though informative, such activity is expensive and error prone.
To support such safety analysis practices, we propose Simulator-based Explanations for DNN failurEs (SEDE), a technique that generates readable descriptions for commonalities in failure-inducing, real-world images and improves the DNN through effective retraining. SEDE leverages the availability of simulators, which are commonly used for cyber-physical systems. It relies on genetic algorithms to drive simulators toward the generation of images that are similar to failure-inducing, real-world images in the test set; it then employs rule learning algorithms to derive expressions that capture commonalities in terms of simulator parameter values. The derived expressions are then used to generate additional images to retrain and improve the DNN.
With DNNs performing in-car sensing tasks, SEDE successfully characterized hazard-triggering events leading to a DNN accuracy drop. Also, SEDE enabled retraining leading to significant improvements in DNN accuracy, up to 18 percentage points.
Blow-Up Solution in Logarithmic Sensitivity and Indirect Signal Generation Keller–Segel System
Authors: Wu Jie , Xie Xinrui 
Published: October 2022

In this paper, we consider the following indirect signal generation and logarithmic sensitivity

ε

n

t

=
Δ
n
−
χ
∇
·

n
∇

ln

c

x
∈
Ω
,
t
>
0

c

t

=
Δ
c
−
c
+
w

x
∈
Ω
,
t
>
0

w

t

=
Δ
w
−
w
+
n

x
∈
Ω
,
t
>
0

under homogeneous Neumann boundary conditions in a ball domain

Ω
⊂

R

N

N
≥
4

with smooth boundary

∂
Ω

. This paper considers in the singular limit

ε
⟶
0

; the result comes from the finite time blow-up of arbitrary large values of

n

in the corresponding nonlocal scalar parabolic equation case when

N
≥
4

and

χ
>

2
N

/

N
−
2

.
Drainage of Complex Walled-Off Pancreatic Fluid Collections in LAMS Era: A Multicenter Study
Authors: Luangsukrerk Thanawat , Harinwan Kamin , Khoo Stanley , Kongkam Pradermchai 
Published: October 2022

Background. The lumen-apposing metal stent (LAMS) has been increasingly used for EUS-guided drainage of symptomatic walled-off pancreatic fluid collection (WOPFC) in recent years. Nevertheless, some WOPFCs may require additional drainage methods including another LAMS as a result of complexity of the lesions. This current study aimed to compare clinical parameters of patients with complex WOPFC requiring LAMS with additional methods (complex WOPFC: group A) versus single LAMS alone (noncomplex WOPFC; group B). Method. Medical records of patients with complex (group A) versus noncomplex WOPFCs (group B) were reviewed and compared in three centers in Thailand and Malaysia, between January 2016 to December 2020. Result. 31 patients with WOPFCs were recruited. 6 of 31 (19%) patients were in group A. Multivariate analysis showed that the maximal diameter of WOPFCs in group A was significantly larger than that of group B (18 ± 6 versus 13 ± 3 cm in diameter, respectively,

p

= 0.021). Solid component proportion was higher in group A versus B (35.8% versus 17.8%, respectively,

p

= 0.025). The prevalence of pancreatic duct leakage was significantly higher in group A (67% versus 20%,

p

= 0.23). The need of direct endoscopic necrosectomy (DEN) and the number of DEN sessions were higher in group A versus B (100% vs. 48%,

p

= 0.020 and 3.5 vs 0

p

= 0.031, respectively). Conclusions. Complex WOPFC had larger diameter of lesions, higher proportion of solid component, higher prevalence of pancreatic duct leakage, and higher number of DEN is required than group noncomplex lesions. Trial Registration. This trial is registered with TCTR20180223004.
A Preliminary Study of the Social History of the Cantonese Chinese Community in Singapore
Authors: Chan Hong Yin 
Published: October 2022

Abstract
This paper aims to provide a historical study of the development of the Cantonese community in Singapore. Through an archival study of various Cantonese associations, it will focus on the connotations of what it means to be Cantonese and the lives of Cantonese people in the context of Singapore. According to a 2020 Singapore population census, the “Cantonese” are currently the third largest Chinese-dialect group, making up almost fifteen percent of the Chinese population on the island state. The term Cantonese, in Singapore, commonly refers to those originating from the vicinity of China’s Guangdong Province, mainly from the south-west region of Guangdong, along the Pearl River Delta. Outnumbered by the Hokkien and Teochew communities, the Cantonese were largely centralized in the Kreta Ayer area and were the dominant dialect group there. Yet, the definition of the term “Cantonese” involves two major issues of geographical location and language system. Being Cantonese, as per the administrative control of Guangdong Province, encompasses all of Chinese descent whose respective ancestral origins are from Guangdong. Moreover, the Cantonese are defined by the unique characteristics of the Cantonese language as well. Therefore, this paper will attempt to differentiate the multiple definitions of the term Cantonese, followed by an overall history of the Cantonese people in Singapore.
Women Guerrillas in the Malayan Communist Insurgency
Authors: Ng Sze-Chieh 
Published: October 2022

Abstract
This article discusses the motivations that led Malayan women to join and fight for the Malayan Communist Party (mcp) via memoirs by the survivors as well as interviews conducted with them. While male mcp members tend to emphasize the glory and righteousness of the Party’s struggle by portraying themselves as willing but passive participants, memoirs of female Party members instead reveal their reasons for becoming fighters to be largely circumstantial. Their reminiscences also tend to be more introspective when recounting their past as a communist guerrilla but were largely unapologetic for their past actions. At the same time, like their male comrades, these women were staunch supporters of the Marxist cause, and some had even worked their way up to leadership positions. Nevertheless, they rarely identify themselves as Marxists, preferring to see themselves as nationalists fighting to establish a just and progressive Malayan nation.
Privacy, Feminism, and Moral Responsibility in the Work of Elizabeth Lane Beardsley
Authors: Van Camp Julie 
Published: October 2022

Abstract
I consider why women philosophers, once recognized, too often seem to drop from the intellectual radar screen or, at least, to drop mainly to the land of footnotes and bibliographies. I consider one distinguished moral philosopher, Elizabeth Lane Beardsley, both to highlight her philosophical contributions and as a case study that suggests more widespread problems in recognizing the work of female philosophers and ensuring their rightful place in our professional dialogue. I consider sociological and professional factors which might partially explain why work by women philosophers has not always received the attention in the professional dialogue it seems to deserve. I conclude with some modest suggestions about the efforts that we can make to address these problems, including the organization of readings for our own courses, the sources consulted for our own research and writing, and the preservation of records of meetings and other public gatherings that recognize women philosophers.
ԱՐՑԱԽԻ ԹԱՂԱՎԱՐԴ ՏԵՂԱՆՈՒՆԸ
Authors: Կիրակոսյան (Hasmik Kirakosyan) Հասմիկ Ց. 
Published: October 2022

Abstract
The earliest attestation of the toponym Taghavard, from Artsakh’s Martuni region, dates back to the 17th century. This coincided with the founding of Avetaranots, the settlement of Varanda’s rulers Melik-Shahnazaryan. Taghavard is located on the right bank of the Köndalan river and to the roads to Avetaranots. This article discusses the identical meaning of river-name Köndalan with the place-name Taghavard and the important role for its interpretation. Taghavard’s geographic location and its function as an entrance to Melik’s settlement deduced the meaning of the toponym as a “corridor pavilion.”
Neurocognitive function of patients with melancholic and non-melancholic major depressive episodes: An exploratory study
Authors: Valerio Marina P , Lomastro Julieta , Igoa Ana , Martino Diego J 
Published: October 2022

Objective: The aim of this exploratory study was to compare the neurocognitive performance of patients undergoing melancholic and non-melancholic major depressive episodes. Considering potential limitations of the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) specifier, we employed an additional tool that has proven useful in identifying melancholia (the Sydney Melancholia Prototype Index). Methods: One hundred forty-one depressed inpatients were classified as melancholic or non-melancholic according to the Sydney Melancholia Prototype Index and the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) criteria and compared on a neurocognitive battery selected to assess attention and processing speed, verbal memory, working memory and executive functions. Results were controlled for several potential confounders. Results: Patients diagnosed as melancholic by the two diagnostic systems displayed lower scores in executive measures, semantic verbal fluency and phonological verbal fluency. On attention and processing speed, patients with melancholia underperformed those with non-melancholic depression only when diagnosed by the Sydney Melancholia Prototype Index. After controlling for confounders, associations between melancholic status and executive dysfunction remained significant for the Sydney Melancholia Prototype Index but not for the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) diagnosis. Conclusion: In this study, melancholia diagnosed by the Sydney Melancholia Prototype Index (but not by the Diagnostic and Statistical Manual of Mental Disorders [5th ed.] criteria) was characterized by a greater compromise of tests assessing executive functions than non-melancholic depressions, even after controlling for depressive severity. These preliminary results might contribute to generating hypotheses about differences in the cognitive profile and pathophysiological substrate between melancholic and non-melancholic depressions. Likewise, the pattern of findings supports the hypothesis that the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) melancholia specifier might identify more severe forms of depressive episodes rather than a qualitatively different subtype.
Representation Is Not Enough: Teacher Identity and Discretion in an Asynchronous, Scripted Online Learning Environment
Authors: Darling-Aduana Jennifer , Hemingway Kristin 
Published: October 2022

Background/Context: Schools are increasingly using scripted curricula that limit teacher autonomy. These limitations are exacerbated when scripted curricula are enacted in fully standardized, asynchronous online course environments with no mechanisms for student–teacher communication. Purpose: This study extends understanding of how teacher discretion, identity, and the relationship between those two components shape students’ educational experiences online. Research Design: Within a sequential mixed method design, we identified spaces for teacher discretion using critical discourse analysis. By coding lesson transcripts, we developed a typology of common strategies: friendly, directive, personalized, and procedural. We used the resulting typology to run statistical models examining associations among teacher identity, discretionary acts, and student achievement. Lastly, we turned back to the qualitative data to confirm findings, test hypotheses, and provide nuance. Findings: Teachers presenting as Black were significantly more likely to use a procedural approach and significantly less likely to use friendly strategies. Students scored higher on their end-of-lesson quiz when their teacher used personalized strategies, such as sharing relevant personal experiences, and scored lower when teachers used friendly or directive strategies. Conclusions: Findings have implications for understanding and enacting equitable educational practices in asynchronous, scripted online environments. The isolation of discretionary acts feasible within the virtual learning environment studied contributes nuance to knowledge of the mechanisms through which teacher discretion might result in more favorable learning outcomes for students belonging to minoritized groups.
The Consequences of Social Media Use Across the Transition Into Adolescence: Body Image and Physical Activity
Authors: Leggett-James Mary Page , Laursen Brett 
Published: October 2022

Children and adolescents spend considerable time online. The current study investigated moderators of short-term longitudinal associations from social media use to changes in body satisfaction and physical activity. Participants (144 girls, 152 boys) were third–sixth grade students (ages 8–13) attending public schools in Florida (USA). Self-reports of social media use, body satisfaction, physical activity, and susceptibility to peer influence were completed twice, approximately 13.5 weeks apart. The results indicated that higher initial social media use was associated with greater subsequent decreases in body satisfaction and physical activity, but only for children high on susceptibility to peer influence. The findings suggest that peer conformity amplifies the risks of social media use. The fact that meaningful change can be identified across a relatively short period of time is noteworthy and demonstrates the need for careful monitoring of those who participate in social media at an early age.
GAS5 alleviates cisplatin drug resistance in oral squamous cell carcinoma by sponging miR-196a
Authors: Yuan Xuguang , Jing Yanan , Guang Mengkai , Zhu Junfei , Wang Ji , Wang Yang , Zhang Ye 
Published: October 2022

Objective The long non-coding RNA Growth-arrest-specific transcript 5 (GAS5) has been extensively linked with the ability of cancer cells to resist chemotherapeutic interventions. This prospective study aimed to investigate the role of GAS5 in oral squamous cell carcinoma (OSCC), which has been poorly characterized to date. Methods GAS5 and miR-196a expression levels were detected by quantitative real-time PCR analysis. Cisplatin (DDP) sensitivity and apoptosis levels were determined using Cell Counting Kit 8 and flow cytometry, respectively. Luciferase reporter and RNA immunoprecipitation assays were performed to confirm target miRNAs of GAS5. Results We found that GAS5 was expressed at low levels in DDP-resistant OSCC cell lines and tissues, and that GAS5 levels were intricately linked to the survival rates of OSCC patients. GAS5 overexpression led to the recovery of DDP sensitivity in CAL27/DDP cells. Additionally, in both DDP-resistant and -sensitive lines, GAS5 showed a cytoplasmic distribution and downregulated miR-196a in OSCC tissues. Exogenous transfection of miR-196a alleviated the effects of GAS5 on DDP sensitivity, confirming this as the mechanism of chemoresistance. Conclusions These findings may provide new targets for the treatment of chemotherapy-resistant OSCC.