bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Non-coding RNAs as Potential Biomarkers for Ischemic Stroke:A Systematic Review
Authors: Zhao Jingjing , Wang Qianwen , Zhu Rui-xia , Yang Jun 
Published: January 2022

Abstract
BackgroundRecent studies have demonstrated that dysregulated non-coding RNAs (ncRNAs) are involved in the pathogenesis of ischemic stroke (IS) including neuroinflammation, apoptosis, atherosclerosis and angiogenesis. However, discrepant results make it difficult to apply ncRNAs into clinical practice. Therefore,we performed this meta-analysis to evaluate and elucidate the diagnostic value of ncRNAs in IS.MethodsWe searched the literature in four databases: PubMed, Web of Science, EMBASE and the Cochrane Library up to December 31, 2020 to identify the relationship between differently expressed ncRNAs and IS. Pooled sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), diagnostic odds ratio (DOR), and corresponding 95% confidence intervals (95%CIs) were calculated to access diagnostic performance of ncRNAs.Results15 studies for miRNAs containing 1687 IS patients and 8 studies for lncRNAs, including 741 IS patients were included in our study. Estimates of the identification efficiency of miRNAs from the 15 studies were: 0.76 (95%CI:0.67-0.84) for SEN, 0.83 (95%CI:0.77-0.88) for SPE, 4.5 (95%CI:3.4-6.1) for PLR, 0.29 (95%CI:0.20-0.40) for NLR, 16 (95%CI:10-26) for DOR. The AUC of the SROC curve showed diagnostic accuracy was 0.87 (95%CI:0.84-0.90), thus the diagnostic value of all the miRNAs was moderate. In addition, the results of lncRNAs were: 0.73 (95%CI: 0.69-0.77) for SEN, 0.75 (95%CI: 0.70-0.79) for SPE, 2.9 (95%CI: 2.4-3.4) for PLR, 0.36 (95%CI: 0.31-0.42) for NLR, 8 (95%CI: 6-11) for DOR, 0.80 (95%CI: 0.76-0.83) for AUC, also a moderate diagnostic value.ConclusionOur study revealed that blood circulating ncRNAs could be a moderately effective candidate biomarker for the diagnosis of IS. Furthermore, combined lncRNAs showed more accurate diagnostic properties than single lncRNAs and some single miRNAs (e.g. miR-107) showed better diagnostic performance, which may contribute to IS clinical practice.
Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis
Authors: Wu Xiaoxin , Sun Antonia Rujia , Crawford Ross , Xiao Yin , Wang Yanping , Prasadam Indira , mao xinzhan 
Published: January 2022

Abstract

Chronic inflammation plays an important role in the osteoarthritis (OA) pathology but how this influence OA disease progression is unclear. Leukotrienes (LT) are biologically active lipids that are implicated in various pathological process. Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator generated from arachidonic acid through the sequential activities of 5-lipoxygenase, 5-lipoxygenase–activating protein, Leukotriene A4 hydrolase (LTA4H) and its downstream product leukotriene B4 (LTB4 or BLT1). The aim of this study is to investigate the involvement of the LTB4 pathway in OA disease progression. Both clinical human samples and mice experimental OA models were used to determine whether LTA4H could serve as a potential therapeutic target for OA. We also determined whether the LTA4H pathway was associated with cartilage degeneration and synovitis inflammation in OA mice models and human articular chondrocytes. We found that both LTA4H and LTB4 receptor BLT1 were highly expressed in human and mice OA cartilage. Inhibition of LTA4H suppressed cartilage degeneration and synovitis in OA mice model. Furthermore, inhibition of LTA4H promoted cartilage regeneration by upregulating chondrogenic genes expression such as aggrecan (ACAN), collagen 2A1 (COL2A1) and SRY-Box transcription factor 9 (SOX9). Our results indicate that the LTA4H pathway is a crucial regulator of OA pathogenesis and suggest that LTA4H could be a therapeutic target in combat OA.
Extracting Metal-Organic Frameworks (MOFs) from Photovoltaic Modules for Wastewater Remediation
Authors: Pham Huu Khue , Sim Ying , Carboni Michaël , Meyer Daniel , Mathews Nripan 
Published: January 2022

Abstract
Photovoltaic (PV) energy adoption has increased drastically over the years and is expected to become a mainstream energy source for the future. However, waste management remains a problem as more PV panels reach their end-of-life. Many strategies have been employed to recycle PV panels, but upcycling efforts to form high-value products from these PV panels are underexplored. In this paper, we have developed 3 different synthetic routes to generate metal-organic framework (MOF), MIL-53(Al), by utilizing the polymeric backsheet and aluminum from solar panels. Characterisations have been performed to evaluate the morphologies, thermal stability, crystallinity, and specific surface areas of the MOFs synthesized. The adsorption performances of these MOFs on cationic Methylene Blue (MB) and anionic Methyl Orange (MO) were determined to be ranging from 186.2 to 263.2 mg/g for MB, and 256.4 to 304.0 mg/g for MO. These results therefore suggest the potential of upcycling solar panels waste to form metal-organic framework for application in wastewater remediation to remove cationic and anionic dyes.
Study on the effect of double-sided laser welding of NiTi shape memory alloys wire
Authors: Ge Fuguo , Zeng Zhi , Peng Bei , Teshome Fissha Biruke , Chen Long 
Published: January 2022

Abstract
NiTi shape memory alloys (SMAs) have important applications in intelligent system design and development due to their flexibility in integration through welding or joining techniques. In this work, both single-sided laser welding and double-sided laser welding processes were used for the welding of NiTi SMAs wire. Then, the macro-morphology, microstructure, phase transformation behavior, mechanical performance, fracture surface characteristics and cyclic tensile properties of the samples obtained under the two welding processes were investigated. The results showed that there were dendrites and equiaxed grains in the fusion zone (FZ) of the double-sided welding samples, without obvious welding defects. Although the phase transformation temperature in the FZ of the samples obtained by the two processes was significantly increased, the temperature rise of the double-sided welded samples was relatively lower. The double-sided welded samples had better tensile strength and elongation, and all samples were ductile fracture. The double-sided welded samples exhibited significant functional fatigue properties improvements compared with the residual strains of the single-sided welded samples in the 1st and 15th cycle tensile tests. This work will improve the performance of NiTi SMAs wire for welding integration applications in smart system design and production.
Automatic Assessment of Calcified Plaque and Nodule by Optical Coherence Tomography Adopting Deep Learning Mode
Authors: Chen Tao , Yu Huai , Jia Haibo , Dai Jiannan , Fang Chao , Ma Lijia , Liu Huimin , Xu Manen , Yu Bo 
Published: January 2022

Abstract
Purpose: Optical coherence tomography (OCT) has become the best imaging tool in assessment of calcified plaque and nodule. However, every OCT pullback has large number of images and artificial analysis need too much time and energy, so it is not suitable for clinical application. This study aimed to develop and validate an automatic assessment of calcified plaque and nodule by OCT using deep learning model.Methods: The OCT images of calcified plaque and nodule were labeled by two expert readers based on the consensus. A deep learning model with a Multi-Scale and Multi-Task u-net network (MS-MT u-net) was developed. Then with the ground truth labeled by expert readers as reference, the diagnostic accuracy and agreement of the model would be validated.Results: For the pixel-wise evaluation of calcified plaque, the model had a high performance with precision (93.95%), recall (88.95%) and F1 score (91.38%). For the lesion-level evaluation of calcified plaque, the quantitative metrics by the model correlated excellent with the ground truth (calcium score, r=0.90, p< 0.01; calcified volume, r=0.99, p＜0.01). For calcified nodules, the model showed an excellent diagnostic performance of model including sensitivity (91.7%), specificity (89.3%) and accuracy (91.0%).Conclusions: We developed a novel deep learning model for identifying attributes of calcified plaque and nodule. This model provides an excellent diagnostic accuracy and agreement with the ground truth, which reduces subjectivity of manual measurements and saves lots of time. These findings would help practitioners efficiently adopting appropriate therapeutic strategy in the treatment of calcified lesions.
Moxibustion Combined With Wuqinxi For Relieving Neck Pain In Cervical Spondylosis: A Randomized Controlled Trial
Authors: Yang Shenqiao , Xu Zhangmeng , Zhou Tiantian , Yang Xingyue , Hui Yuhao , Zhou Hui , Fang Zimin 
Published: January 2022

Abstract
Background: Evidence has shown that moxibustion and wuqinxi can relieve neck pain respectively, however the combined effect of the two treatments is still unclear. This study aim to investigate the alleviating effect of moxibustion combined with wuqinxi exercises on neck pain in patients with cervical spondylosis.Methods: One hundred patients with neck pain due to cervical spondylosis were screened and randomly equally divided into a moxibustion group (MG), a wuqinxi group (WG), a combination group (receiving moxibustion combined with wuqinxi) (MW), and a control group (CG). The MG received moxibustion for 20 min each time; the WG were required to practice wuqinxi for 20 min each time; the MW received moxibustion and practiced wuqinxi; and the CG were treated after the trial. The frequency of treatment was five times per week. The primary outcome measured was the change in the simple McGill Pain Questionnaire (MPQ) score between pre- and post-intervention measurements.Results: There were no significant differences at baseline among the four groups. After the intervention, the MPQ scores of the MG (6.9±3.9), WG (7.6±3.6), and MW (4.6±2.7) were significantly lower than that of the CG (16.4±4.3). The MPQ score decreased by 10.0±6.3 in the MG, 11.3±6.8 in the WG, 13.1±5.2 in the MW, and −0.2±3.0 in the CG. There were no significant differences in the change in MPQ score between the MW, MG and WG. The neck disability index (NDI), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS) scores of the MG, WG, and MW all decreased, but those of the CG did not change significantly. In comparison with the MG and WG, the changes in the NDI, SAS, and SDS scores of the MW were not significantly different.Conclusion: Our study suggests that four weeks of moxibustion or wuqinxi can alleviate symptoms of neck pain in patients with cervical spondylosis. However, the effect of moxibustion combined with wuqinxi was no better than that of moxibustion or wuqinxi alone.Trial registration: ChiCTR2000034258. Retrospectively registered: 29/06/2020.
Buspirone Effectiveness in treatment of SSRI induced Bruxism, a comprehensive systematic review
Authors: Zarzar Luluwa , Khalifa Samar 
Published: January 2022

Abstract
The aim of this paper is to do a systematic review using the PRISMA flow system about Buspirone role in treatment of induced bruxism by selective serotonin reuptake inhibitors SSRIs families. We did a comparison between patients with bruxism who received intervention by Buspirone and the controls of Buspirone intervention in a review. We included in the review the research articles including case reports and full text articles and excluded the systematic and literature reviews in purpose of having specific data about the topic. The databases were Pubmed and Google scholar.
Global profiling of alternative splicing in non-small cell lung cancer reveals novel histological and population differences
Authors: Zeeshan Saman , Mendelez Rony A. , Zingone Adriana , Khiabanian Hossein , Pine Sharon R. , Ryan Bríd M. 
Published: January 2022

Abstract

Lung cancer is one of the most frequently diagnosed cancers with higher incidence and mortality rates in African-American (AA) men compared to European-American (EA) men. Here, we report high-confidence alternative splicing (AS) events from high-throughput, high-depth total RNA-sequencing of lung tumors and non-tumor adjacent tissues (NATs) from two independent cohorts of patients with adenocarcinoma and squamous cell carcinoma. We uncover tumor subtype- and population-specific AS events different between AAs and EAs, associated with oncogenic signaling pathways, cell surface proteins, and cancer driver genes. We highlight significant AS events in SYNE2 specific to LUAD in both populations as well as those in CD44 from EAs and TMBIM6 from AAs specific to LUAD. Our large survey of lung tumors presents a rich data resource that can help uncover new therapeutic vulnerabilities that potentially advance health equity.
Hypo vs. hyperthyroid eye disease: Is there any difference?
Authors: Eshraghi Bahram , Pourazizi Mohsen , Abbasi Maryam , mohammadbeigy iman 
Published: January 2022

Abstract
Background

Thyroid-eye disease (TED) is the most common extra-thyroidal presentation of graves’ disease. We performed this study to compare clinical characteristics of TED in hypothyroid vs. hyperthyroid patients.
Methods

This was a retrospective analytical cross-sectional study in which we compared demographics, severity (EUGOGO classification) and activity (clinical activity score) of TED, thyroid disease duration, TED duration and clinical signs between hypothyroid eye disease (Ho-TED) and hyperthyroid eye disease (Hr-TED).
Results

Three hundred and seventy-four patients (341 Hr-TED and 33 Ho-TED) with a female to male ratio of 1.4:1 were identified in our study. Female to male ratio was 1.3:1 in hyperthyroid and 4.5:1 in hypothyroid group (P=0.005). The duration of thyroid disease was longer in Ho-TED (P=0.002) while the duration of eye disease was longer in Hr-TED (P=0.92). Most of the patients in hyperthyroid (153,48.1%) and hypothyroid group (24, 80.0%) developed eye involvement after thyroid disease (P=0.003). Severity (P=0.13) and activity (P=0.11) was not different between Hr-TED and Ho-TED patients (Table 1).
Conclusion

The result of our study showed several differences between the Hr/Ho TED patients included sex, duration of thyroid disease and pattern of eye involving.
Suicide vs Homicide Firearm Injury Patterns, Weapons, and Mortality: A Study of the National Trauma Data Bank (NTDB)
Authors: Foote Christopher Wayne , Doan Xuan-Lan , Vanier Cheryl , Cruz Bianca , Sarani Babak , Palacio Carlos H. 
Published: January 2022

Abstract
Background: Gun related mortality rate in the USA surpassed other developed countries. This study hypothesizes that injury patterns, weapon type, and mortality differ between suicide groups as opposed to homicide. Methods: The National Trauma Database (NDTB) was queried from January 2017 to December 2019. All firearm related injuries were included, and weapon type was abstracted. Differences between homicide and suicide groups by sex, age, race, and injury severity were compared using a Mann-Whitney test for numerical data and Fisher’s exact test for categorical data. The association between weapon type and mortality relative to suicide as opposed to homicide was assessed in Fisher’s exact tests. Significance was defined as p < 0.05. Results: There was 100,031 homicide and 11,714 suicide subjects met inclusion criteria. Homicides were mostly assault victims (97.6%), male (88%), black (62%), less severe injury (mean ISS 12.07) and median age 20 years old (IQR: 14, 30), (p < 0.01). Suicides were mostly male (83%), white (79%), more severe injury (mean ISS 20.73), and median age of 36 years old (IQR: 19, 54, p < 0.01). Suicide group had higher odds of head/neck (OR=13.6) or face (OR=5.7) injuries, with lower odds of injury to chest (OR=0.55), abdominal or pelvic contents (OR=0.25), extremities or pelvic girdle (OR=0.15), or external areas (OR=0.32). Mortality rate was higher for suicide group (44.8%; 95% confidence interval (CI): 43.9%, 45.7%) compared to the homicide group (11.5%; 95% CI: 11.3%, 11.7%). Conclusions: Suicide had higher mortality, more severe injuries, and more head/neck/facial injuries than homicide. Majority of suicides were with handguns. Level of Evidence: Level IV
Effects of Intravitreal Injection of Hypoxia-Induced Umbilical Cord Mesenchymal Stem Cell Exosomes on Diabetic Retinopathy
Authors: Fu Yan , Gu Zhao-Hui , Wen Xiao-Ying , Yang Na 
Published: January 2022

Abstract
BACKGROUND: This study aims to investigate the effect of intravitreal injection of hypoxia-induced human umbilical cord mesenchymal stem cell exosomes (hypo-hucMSC-Exs) on retinal microvasculature in rats with diabetic retinopathy (DR) and to determine whether hypo-hucMSC-Exs exhibit greater effects on DR than human umbilical cord mesenchymal stem cell exosomes (hucMSC-Exs)METHODS: Exosomes were isolated from normal hucMSCs culture media and hypoxic preconditioning culture media. transmission electron microscope, nanoparticle tracking analysis, and western blot were applied to identification of hucMSC-Exs. Streptozotocin-induced diabetic rats were used as a model for DR. Fundus fluorescein angiography (FFA) was conducted to evaluate retinal microvasculature changes in vivo 4 week, 8 weeks and 12 weeks following intravitreal injection.RESULTS: The control group did not experience any significant change throughout the study. After STZ injection, all rats developed hyperglycemia. The development of retinal microvascular changes include tortuous vessels, massive microaneurysms and late leakage of fluorescein dye was visualized using FFA after induction of DR. This response was ameliorated in diabetic rats treated with hucMSC-Exs. To further investigate the effects of hypo-hucMSC-Exs we found that injection with hypo-hucMSC-Exs remarkably reduced the microvasculature lesions compared with the hucMSC-Exs group. CONCLUSION: These findings suggest that intravitreal injection of hucMSC-Exs prevented diabetes-induced microvasculature lesions. hypo-hucMSC-Exs could enhance this effects and could be considered as a potential target for DR prevention and treatment.
Drinking water quality and health risk assessment of intake and point-of-use water sources in Tano North Municipality, Ghana
Authors: Yeboah Saeed Ibn Idris K. , Antwi-Agyei Prince , Domfeh Martin Kyereh 
Published: January 2022

Abstract
This study assessed the change in the quality of drinking water from the intake to point-of-use and the health risk to consumers of the water sources in a farming community in Ghana. Water samples were collected from five intake sources and point-of-use sources from 31 households. A quantitative microbial risk assessment (QMRA) was used to estimate the health risk. All the physicochemical parameters were found to be within the WHO guidelines except pH and water hardness. Again, none of the physicochemical parameters showed a significant difference between intake and point-of-use water sources. There were, however, significant differences in the mean total and fecal coliforms between the intake source and point-of-use source (3.63 vs 4.57 log CFU/100 mL and 1.38 vs 2.83 log CFU/100 mL, respectively). The results of the QMRA showed that the disease burden arising from exposure to river and spring water sources were above the WHO reference tolerable risk level of 1 × 10−6 Disability-Adjusted Life Years per person per year. The results of this study are expected to influence relevant stakeholders toward initiating plans that could mitigate the spread of waterborne diseases and avert the related economic implications in the study community.
Application of the Water Service Sustainability Index to water services in sub-Saharan Africa: the case studies of eight councils in the Southern region of Cameroon (Central Africa)
Authors: Mvongo Victor Dang , Defo Célestin , Tchoffo Martin 
Published: January 2022

Abstract
The aim of this article is to assess the sustainability of rural water service in the Mvila Division (Southern region of Cameroon) in order to constructively feed the debate on the most effective ways to improve access to rural water service in sub-Saharan Africa. The methodological approach was based on the application of the Water Service Sustainability Index (WSSI) and was implemented through technical inspection of the rural drinking water supply system (RDWSS), the semi-structured interview, and a survey of 103 service providers. Results show that the sustainability performance of rural water service in the Mvila Division is poor–medium. The highest aggregate value of the WSSI was obtained in the Mvangan council (59.54%) followed by the Ngoulemakong council (47.99%), Biwong Bulu (38.53%), Efoulan (33.99%), Biwong Bane (31.51%), Ebolowa I (28.96%), Ebolowa II (28.19%), and Mengong (26.57%). Results also show that rural water service is influenced by factors such as the low pricing of rural water service, climate risk, the poor structuring of the maintenance chain, and the weak commitment of the municipal authorities. However, this study represents only a current snapshot of rural water service delivery conditions and should be conducted at regular intervals to track changes in overall and local conditions.
Parasitological, microbiological, and antimicrobial resistance profiles of raw and drinking water in a tourist city in the tri-border region of South America
Authors: Scherer Gustavo Strieder , Leal Diego Averaldo Guiguet , Greinert Goulart Juliane Araújo , Araújo Ronalda Silva , Beux Marcia Regina , Moreira Neide Martins 
Published: January 2022

Abstract
Despite the large amounts of freshwater available in Brazil, the deterioration of surface water can represent a risk of waterborne disease for national and international tourists. The main goal of this study was to assess the quality of drinking water in the triple border region of Brazil before and after being treated in water treatment plants (WTPs) and in Municipal Early Childhood Education Centers (MECECs), in terms of parasitological, microbiological, and physical–chemical aspects. Different water samples were monitored: raw water (RW), treated water (TW), and tap water from the MECECs, giving 60 samples in total, to investigate the presence of Giardia and Cryptosporidium, microbiological indicators, Pseudomonas aeruginosa, and antimicrobial resistance profiles using conventional microbiological assays and parasitological, immunological, and molecular techniques. The results obtained were compared with the reference values recommended by the legislation of drinking water in Brazil. For the first time, contamination by Cryptosporidium and Giardia was demonstrated in RW used to supply WTPs, in TW of Foz do Iguaçu, and in water destined for consumption by children. A total of 52 bacterial isolates were obtained, with high percentages of multidrug resistance to antibiotics, including a carbapenem-resistant profile, highlighting the need to improve quality control standards.