bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dexterous robotic manipulation using deep reinforcement learning and knowledge transfer for complex sparse reward‐based tasks
Authors: Wang Qiang , Sanchez Francisco Roldan , McCarthy Robert , Bulens David Cordova , McGuinness Kevin , O'Connor Noel , Wüthrich Manuel , Widmaier Felix , Bauer Stefan , Redmond Stephen J. 
Published: December 2022

AbstractThis paper describes a deep reinforcement learning (DRL) approach that won Phase 1 of the Real Robot Challenge (RRC) 2021, and then extends this method to a more difficult manipulation task. The RRC consisted of using a TriFinger robot to manipulate a cube along a specified positional trajectory, but with no requirement for the cube to have any specific orientation. We used a relatively simple reward function, a combination of a goal‐based sparse reward and a distance reward, in conjunction with Hindsight Experience Replay (HER) to guide the learning of the DRL agent (Deep Deterministic Policy Gradient [DDPG]). Our approach allowed our agents to acquire dexterous robotic manipulation strategies in simulation. These strategies were then deployed on the real robot and outperformed all other competition submissions, including those using more traditional robotic control techniques, in the final evaluation stage of the RRC. Here we extend this method, by modifying the task of Phase 1 of the RRC to require the robot to maintain the cube in a particular orientation, while the cube is moved along the required positional trajectory. The requirement to also orient the cube makes the agent less able to learn the task through blind exploration due to increased problem complexity. To circumvent this issue, we make novel use of a Knowledge Transfer (KT) technique that allows the strategies learned by the agent in the original task (which was agnostic to cube orientation) to be transferred to this task (where orientation matters). KT allowed the agent to learn and perform the extended task in the simulator, which improved the average positional deviation from 0.134 to 0.02 m, and average orientation deviation from 142° to 76° during evaluation. This KT concept shows good generalization properties and could be applied to any actor‐critic learning algorithm.
Evolution of deep‐sea fisheries policies in China: Review, performance and prospects
Authors: Yu Jinkai , Wang Yan 
Published: December 2022

AbstractDeep‐sea fisheries policies promulgated by the Chinese government have contributed to healthy development of deep‐sea fisheries. Using content analysis, we explored the evolution of 159 deep‐sea fisheries policy documents enacted in China since 1979. These policies were divided into three periods: initial start‐up during 1979–2002, optimisation and adjustment during 2003–2016 and rapid development during 2017–2021. During the optimisation and adjustment period, deep‐sea aquaculture policies predominated (more than 80%) and policy focus shifted from deep‐sea fishing to deep‐sea aquaculture. Since then, policy power has intensified, and policy support modes evolved from single to diverse. Future deep‐sea fisheries policies should strengthen scientific and technological innovation support, build stakeholder interest consultation mechanisms, strengthen supervision of ecological impacts on surrounding sea areas and adhere to sustainable development goals.
Visiting here, there, and somewhere: Multi‐locality and the geographies of transnational family visiting
Authors: McNeil‐Walsh Colleen Elizabeth 
Published: December 2022

AbstractFor transnational families, visits represent an opportunity to temporarily punctuate the geographical distance that separates them from significant others in everyday life. Drawing on data from mapping‐interviews conducted with older skilled migrants in Abu Dhabi, the UAE, this paper is concerned with how transnational visiting is harnessed to sustain a sense of family togetherness at a later stage of the life course. The discussion contributes to migration scholarship on return visits and visits by relatives to the migration destination but also draws attention to a third dimension of visiting; family meet‐ups in a third space—a location that is neither the country of origin nor the migration destination. Hence, I propose an explicitly spatial, relational conceptualization of transnational family visits, arranged around a multi‐local framework: the return visit (‘there’); the receiving of visits in the migration destination (‘here’); and visits in an in‐between geographical space (‘somewhere’). In so doing, this paper places the spotlight on the geographies of visiting, drawing attention to the dynamic way in which the practice of transnational family visiting in enacted in later life.
Evolution of prevention of vertical HIV transmission in Uganda: 2008–2017
Authors: Nahirney Marissa , Grist Jesse , Namasopo Sophie , Brophy Jason , Hawkes Michael T. 
Published: December 2022

AbstractObjectivesUganda adapted its policy for prevention of vertical transmission (VT) of HIV transmission as the World Health Organization released Options A, B and B+. We assessed trends in diagnostic testing, breastfeeding practices, maternal and infant antiretroviral therapy (ART), mortality, VT and HIV‐free survival (HFS) among Ugandan infants born to women living with HIV during this period of successive guideline changes.MethodsThis is is a retrospective observational study of infants attending early infant diagnosis clinics at two Ugandan hospitals.ResultsA total of 1885 infants (48% female) were managed from 2009 to 2017. DNA polymerase chain reaction (PCR) for early infant diagnosis was performed on 1719 infants (92%, one or more PCR tests) and 676 infants (36%, two PCR tests). HIV serology was performed on 90 infants (4.8%). Testing increased over the study period but remained suboptimal, due to high loss to follow‐up (LTFU). A total of 93% of infants were breastfed, for a median of 9.5 months. The duration of breast milk exposure increased over the study period, consistent with guidelines that increasingly encouraged breastfeeding. Nine cases (0.48%) of suspected breast milk transmission were observed. The use of ART increased significantly over the study period. Mortality (3.5%, 2.7% and 1.1%; p = 0.0076) and VT (17%, 12% and 7.4%; p < 0.0001) decreased over the study period (2008–2010, 2011–2012 and 2013–2017, respectively). LTFU values were 31%, 49% and 59% at 6, 12 and 18 months of age, respectively, with only modest improvements over time. HFS could only be conclusively documented in 532 infants (28%) because of LTFU.ConclusionsFrom 2009 to 2017, outcomes improved among HIV‐exposed infants in Uganda. LTFU remains a barrier to optimal care.
Moisturizing at a molecular level – The basis of Corneocare
Authors: Voegeli Rainer , Rawlings Anthony V. 
Published: December 2022

AbstractThis review covers the last 20 years of research we and our collaborators have conducted on ethnic differences in facial skin moisturization placed in historical context with previous research. We have focussed particularly on the biochemical and cellular gradients of the stratum corneum (SC) with the aim of discovering new skin moisturization and SC maturation mechanisms, identifying new technologies and/or providing conceptual innovations for ingredients that will improve our understanding and treatment of dry skin. Specifically, we discuss gradients for corneodesmosomes and proteases, corneocyte phenotype‐inducing enzymes, filaggrin and natural moisturizing factor (NMF), and barrier lipids. These gradients are interdependent and influence greatly corneocyte maturation. The interrelationship between corneodesmolysis and the covalent attachment of ω‐hydroxy ceramides and ω‐hydroxy fatty acids to the corneocyte protein envelope forming the corneocyte lipid envelope is especially relevant in our new understanding of mechanisms leading to dry skin. This process is initiated by a linoleoyl‐ω‐acyl ceramide transforming enzyme cascade including 12R lipoxygenase (12R‐LOX), epidermal lipoxygenase‐3 (eLOX3), epoxide hydrolase 3 (EPHX3), short‐chain dehydrogenase/reductase family 9C member 7 (SDR9C7), ceramidase and transglutaminase 1. Our research has opened the opportunity of using novel treatment systems for dry skin based on lipids, humectants, niacinamide and inhibitors of the plasminogen system. It is clear that skin moisturization is a more complex mechanism than simple skin hydration.
You ruined our love story, but I just cannot hate you—A moderation–mediation analysis of past experienced brand love and brand hate
Authors: Brandão Amélia , Ribeiro Bruno , Gadekar Mahesh 
Published: December 2022

AbstractThe development of the consumer–brand relationship is crucial for brands as it reflects how well a consumer is emotionally connected with the brand. However, due to unacceptable behaviour, brands have become susceptible to negative consumer–brand relationships. Given the recent importance of the negative consumer–brand relationship and its consequences, little is known about the role of previously experienced brand love. Studies support the link between strongly remembered events and experiences, customer knowledge, brand association, and consumer congruence with brands in creating long‐lasting influence and deep emotion towards the brand. The study examines moderation–mediation analysis of past experienced brand love and brand hate. This research, anchored in consumer brand relationship literature, builds on an analysis of data from 207 respondents. We conducted a research survey in a South‐Western European country and performed the SPSS Hayes Process macro 58 to analyse the moderating role of past experienced brand love alongside the mediating role of brand hate to test our hypotheses. The moderation results show that past experienced brand love significantly moderated the link between brand hate causes (corporate wrongdoings) and brand hate. However, there is no significant moderation influence of past experienced brand love on the consequences of brand hate causes. The study also demonstrates that brand hate mediates the link between corporate wrongdoings and violations of expectations with negative word of mouth, consumer complaints, and patronage reduction/cessation. The current study is unique in that it highlights new avenues in existing research by extending the domain in consumer–brand relationships. The findings of the study have theoretical and empirical implications for brand managers.
Expanding the molecular and morphological diversity of Apusomonadida, a deep‐branching group of gliding bacterivorous protists
Authors: Torruella Guifré , Galindo Luis Javier , Moreira David , Ciobanu Maria , Heiss Aaron A. , Yubuki Naoji , Kim Eunsoo , López‐García Purificación 
Published: December 2022

AbstractApusomonads are cosmopolitan bacterivorous biflagellate protists usually gliding on freshwater and marine sediment or wet soils. These nanoflagellates form a sister lineage to opisthokonts and may have retained ancestral features helpful to understanding the early evolution of this large supergroup. Although molecular environmental analyses indicate that apusomonads are genetically diverse, few species have been described. Here, we morphologically characterize 11 new apusomonad strains. Based on molecular phylogenetic analyses of the rRNA gene operon, we describe four new strains of the known species Multimonas media, Podomonas capensis, Apusomonas proboscidea, and Apusomonas australiensis, and rename Thecamonas oxoniensis as Mylnikovia oxoniensis n. gen., n. comb. Additionally, we describe four new genera and six new species: Catacumbia lutetiensis n. gen. n. sp., Cavaliersmithia chaoae n. gen. n. sp., Singekia montserratensis n. gen. n. sp., Singekia franciliensis n. gen. n. sp., Karpovia croatica n. gen. n. sp., and Chelonemonas dolani n. sp. Our comparative analysis suggests that apusomonad ancestor was a fusiform biflagellate with a dorsal pellicle, a plastic ventral surface, and a sleeve covering the anterior flagellum, that thrived in marine, possibly oxygen‐poor, environments. It likely had a complex cell cycle with dormant and multiple fission stages, and sex. Our results extend known apusomonad diversity, allow updating their taxonomy, and provide elements to understand early eukaryotic evolution.
A review of commercial process simulators applied to food processing
Authors: Ureta M. Micaela , Salvadori Viviana O. 
Published: December 2022

AbstractThe aim of this paper is to give a state of art of the application of commercial process simulators that describes food process transformations from a macro approach, considering the mass and energy balances and the physical and chemical changes, immersed in the context of the whole industrial plant. Most popular commercial software's and its characteristics are exposed. Additionally, the most relevant works in the field are discussed, with emphasis on physicochemical properties of food matrices, the selection of the fluid package and strategies to simulate several common processing stages involved. This review includes a wide variety of food and beverages process like evaporation, concentration, distillation, fermentative reactions, membrane separation and oil refining. Simulated models are an effective tool when several scenarios need to be considered. This area orientated to food processing simulation, still needs to incorporate equation‐oriented approaches and adapt to more versatile operational management.
Involvement of brain‐derived neurotrophic factor methylation in the prefrontal cortex and hippocampus induced by chronic unpredictable mild stress in male mice
Authors: Cheng Shuyue , Wang Wei , Zhu Zemeng , Zhao Mingyue , Li Hannao , Liu Dexiang , Pan Fang 
Published: December 2022

AbstractEarly life stress alters brain‐derived neurotrophic factor (BDNF) promoter IV methylation and BDNF expression, which is closely related to the pathophysiological process of depression. However, the role of abnormal methylation of BDNF induced by stress during adolescence due to depression has not yet been clarified. In this study, adolescent mice were exposed to chronic unpredictable mild stress (CUMS). Depression‐like behaviors, BDNF promoter IV methylation, expression of DNA methyltransferases (DNMTs), demethylation machinery enzymes, BDNF protein levels, and neuronal development in the prefrontal cortex (PFC) and hippocampus (HIP) were assessed in adolescent and adult mice. The DNMT inhibitor, 5‐Aza‐2‐deoxycytidine (5‐AzaD), was used as an intervention. Stress in adolescence induces behavioral dysfunction, elevated methylation levels of BDNF promoter IV, changes in the expression of DNMT, and demethylation machinery enzymes in adolescent and adult mice. Additionally, the stress in adolescence induced lower levels of BDNF and abnormal hippocampal doublecortin (DCX) expression in adolescent and adult mice. However, DNMT inhibitor treatment in adolescent‐stressed mice relieved the abnormal behaviors, normalized the methylation level of BDNF promoter IV, BDNF protein expression, expression of DNMTs, and demethylation machinery enzymes, and improved the neuronal development of adult mice. These results suggest that stress in adolescence induces short‐ and long‐term hypermethylation of BDNF promoter IV, which is regulated by DNMTs, and leads to the development of depression.image
Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice
Authors: Kawaguchi Yohei , Hagiwara Daisuke , Tsumura Tetsuro , Miyata Takashi , Kobayashi Tomoko , Sugiyama Mariko , Onoue Takeshi , Yasuda Yoshinori , Iwama Shintaro , Suga Hidetaka , Banno Ryoichi , Grinevich Valery , Arima Hiroshi 
Published: December 2022

AbstractArginine vasopressin (AVP) is expressed in both magnocellular (magnAVP) and parvocellular AVP (parvAVP) neurons of the paraventricular nucleus, and AVP colocalizes with corticotropin‐releasing hormone (CRH) only in the parvocellular neurons. The immunoglobulin heavy chain binding protein (BiP) is a major endoplasmic reticulum (ER) chaperone which regulates the unfolded protein response under ER stress. We previously demonstrated that knockdown of BiP in magnAVP neurons exacerbated ER stress, which resulted in the autophagy‐associated cell death of magnAVP neurons. Using the same approach, in the present study we examined the role of BiP in mouse parvAVP/CRH neurons. Our data demonstrate that BiP is expressed in mouse parvAVP/CRH neurons under nonstress conditions and is upregulated in proportion to the increase in CRH expression after adrenalectomy. For BiP knockdown in parvAVP/CRH neurons, we utilized a viral approach in combination with shRNA interference. Knockdown of BiP expression induced ER stress in parvAVP/CRH neurons, as reflected by the expression of C/EBP homologous protein. Furthermore, BiP knockdown led to the loss of parvAVP/CRH neurons after 4 weeks. In summary, our results demonstrate that BiP plays a pivotal role in parvAVP/CRH neurons, which function as neuroendocrine cells producing a large number of secretory proteins.
Temporariness made interminable: Pacific Islander farmworkers in Australia and the enduring crises of global agricultural production
Authors: Stead Victoria 
Published: December 2022

AbstractDrawing on long‐term ethnographic fieldwork with Seasonal Worker Programme (SWP) workers in south‐east Australia, I reflect in this paper on the experience of interminable temporariness and on its implications for the structural conditions underpinning contemporary horticultural labour in Australia. Although in many ways reflective of the specificities of a unique historical moment, the interminable temporariness experienced through the COVID‐19 pandemic also speaks to broader, enduring conditions produced within contemporary Australian agriculture. Here, the restructuring of the agri‐industry produces for many what Lauren Berlant describes as the “impasse” or “crisis ordinariness” of life under neoliberalism. At the same time, logics of development—including racialized imaginaries and border regimes—articulate with agricultural guest worker schemes in ways that seek to fix whole populations and regions in relations of suspended hope. In this context, I argue, the pandemic exposed and intensified structural vulnerabilities and unequal distributions of risk, which are encoded in the political economy of farm work in Australia, while also cleaving open new, if tentative, possibilities for agency and solidarity.
Apparent and standardised ileal amino acid digestibilities in heat‐stressed pigs fed wheat‐soybean meal diets supplemented with l‐arginine and dl‐methionine
Authors: Valle Alan , Cervantes Miguel , Morales Adriana , Castillo Gilberto , Montoya Estela , González‐Vega Jollie Caroline , Htoo John K. , Avelar Ernesto 
Published: December 2022

AbstractHeat stress (HS) exposure may damage the small intestine epithelia of pigs affecting the digestibility and absorption of amino acids (AA). Arg and Met can enhance antioxidant and intestinal cell proliferation activity, thus supplementing them in diets might alleviate epithelial damage and correct the reduced AA digestibility. The effect of adding extra l‐Arg and dl‐Met to diets on the apparent (AID) and standardised ileal digestibility (SID) of AA was analysed in a 10‐day experiment conducted with 10 ileal‐cannulated HS pigs (25.3 ± 2.4 kg body weight). The pigs were divided into two treatments: Control, wheat‐soybean meal diet supplemented with l‐Lys, l‐Thr, dl‐Met and l‐Trp; and control diet plus 0.20% l‐Arg and 0.20% dl‐Met (Arg + Met). Following an 8‐day diet adaptation period, ileal digesta was continuously collected for 12 h, starting at 0700, on Days 9 and 10. All pigs were daily exposed to 29.6–36.1°C; ileal temperature was continuously monitored at 15‐min intervals. Feed was provided twice a day. The ileal temperature ranged from 40.3 to 41.5°C. Daily ileal outflow of His, Ile, Leu, Phe, Thr, Ser and Tyr decreased (p < 0.05), and that of Arg, Val and Pro tended to decrease (p < 0.10) in the Arg + Met pigs. The AID of Arg, His, Met, Thr and Tyr, and the SID of His, Met, and Thr increased in pigs fed the Arg + Met diet (p < 0.05). Thr and Val had the lowest AID values whereas Arg, Met, and Lys had the highest values. Arg (r = 0.64) and Met (r = 0.84) intake were highly correlated with their AID values; Met intake was highly correlated with its SID value (r = 0.72). Valine and Arg had the lowest whereas Arg had the highest SID values. In conclusion, supplementing l‐Arg and dl‐Met above the requirement decreases the ileal outflow of several AA, and increases the AID and SID of some essential AA in HS pigs.
Estimating small structural motions based on sparsity enforcement
Authors: Cai Enjian , Zhang Yi , Lu Xinzheng , Ji Xiaodong , Li Yinbin , Li Jianying , Song Xinyu , Zhang Hong , Liu Yong 
Published: December 2022

AbstractThis paper proposed a novel, efficient method to estimate challenging small structural motions from noisy video. To eliminate the phase limitation, ill‐posed problem, and high computational burden, the structural motion function is resampled and recovered. Because video signals have tremendous redundancies in spatial, block, and time domains, the objective is achieved by enforcing three levels of sparsity constraints. In the first step, the ill‐posed optimization is solved using the multi‐hypothesis prediction embedded with the Tikhonov regularization, to resample and recover the video signal in the spatial domain. The second step is to characterize the measurement uncertainty in the block domain, in which two weight matrices are proposed into the regularization terms of the sparse coding. Finally, the temporal correlation of video frames is exploited by the reweighted residual sparsity. The superiority of the sparsity‐enforcement method over existing methods was demonstrated through several case studies. Among the comparisons, the sparsity‐enforcement method yielded video magnifications, structural motions, and modal information more accurately. Meanwhile, it has the lowest computational burden.
The use of progressive addition lenses to improve the daily visual function of children receiving topical atropine treatment
Authors: Sun Han‐Yin , Tsai Jeng‐Dau , Nien Ying‐Shan , Peng Chien‐Chun , Ke Ching‐Hsiu , Kuo Hui‐Ying 
Published: December 2022

AbstractPurposeTo evaluate the changes in visual function when progressive addition lenses (PAL) are added in children using topical atropine as a myopia control therapy. Daily visual complaints and the determination of their near correction were studied.MethodsForty children aged 7–12 years were recruited. Distance and near visual acuity, accommodative lag, heterophoria, near point of convergence and stereopsis were examined, and a questionnaire of daily visual complaints was administered.ResultsSignificant differences in visual functions were found after the near correction was prescribed. Significant improvements in distance and near visual acuity, lag of accommodation and binocular visual function were observed, and fewer visual complaints were reported at the Harmon distance.ConclusionThe use of PAL is helpful for children undergoing topical atropine treatment for myopia control, particularly those receiving medium to high doses. This combination therapy could also be applied to younger children who have a low tolerance to contact lenses, with less risk of ocular adverse effects.