bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data Governance – Datenteilung in Ökosystemen rechtskonform gestalten
Authors: Weber Beatrix , Gernert Regine 
Published: October 2022

ZusammenfassungDie Europäische Union strebt mit einem Bündel von Verordnungsentwürfen die Ausgestaltung des Rechtsrahmens für Datenräume an. Mit dem Vorschlag eines Data-Governance-Gesetzes soll die Grundlage für einen zukünftigen Rechtsrahmen der Datennutzung und der Datenmärkte gelegt werden. Neben dem Datentransfer aus dem öffentlichen in den privaten Sektor und der Datenspende wird das Anbieten von Diensten für die gemeinsame Datennutzung (Datenmittlung) geregelt. Das Teilen von Daten soll rechtskonform gestaltet werden können, um die Entstehung von Datenräumen auch wirtschaftlich zu ermöglichen.Anbietern von Diensten für das Teilen von Daten, sogenannten Datenmittlern, wird eine Schlüsselrolle in der Datenwirtschaft zugeschrieben. Sie schaffen Plattformen, die das Aggregieren und den Austausch erheblicher Mengen einschlägiger Daten erleichtern, und verbinden die verschiedenen Akteure miteinander. Sie unterstützen sowohl das Teilen von Daten mehrseitiger Herkunft für mehrseitige Nutzung als auch den bilateralen Datenaustausch von Unternehmen zu Unternehmen. So kann zukünftig eine „neuartige europäische Art der Data Governance“ für datengetriebene offene Ökosysteme auf der Basis neutraler Datenmittler entstehen.Unternehmen, die Datenbestände als Anbieter oder Nutzer innovativ einsetzen wollen, benötigen Modelle zur Datennutzung und eine Data Governance, die die künftigen gesetzlichen Vorgaben umsetzt und hierbei Technik, Ökonomie und Recht verbindet. Data Governance ist das Zukunftsmodell für alle datengetriebenen Innovationen, um die Teilhabe an Daten und datenbasierten Innovationen auch für KMU niederschwellig und rechtskonform zu ermöglichen und Markteinschränkungen aufgrund von Datenabhängigkeiten zu vermeiden. In diesem Beitrag wird für Entscheidungsträger in Unternehmen der aktuelle Rechtsrahmen erläutert und im Kontext von zukünftigen Ökosystemen bewertet.
Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infection
Authors: Zhou Xinying , Xu Hui , Li Qianna , Wang Qi , Liu Honglin , Huang Yingqi , Liang Yao , Lie Linmiao , Han Zhenyu , Chen Yaoxin , Huang Yulan , Zhou Wenle , Wen Qian , Zhou Chaoying , Hu Shengfeng , Ma Li 
Published: October 2022

Abstract
Objectives and design
Dendritic cells (DCs) are one of the key immune cells in bridging innate and adaptive immune response against Mycobacterium tuberculosis (Mtb) infection. Interferons (IFNs) play important roles in regulating DC activation and function. Virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (Viperin) is one of the important IFN-stimulated genes (ISGs), and elicits host defense against infection.

Methods
We investigated the effects and mechanisms of Viperin on DC activation and function using Viperin deficient bone marrow-derived dendritic cells (BMDCs) during Mtb infection.

Results
Viperin deficiency enhanced phagocytic activity and increased clearance of Mtb in DCs, produced higher abundance of NO, cytokine including interleukin-12 (IL-12), Tumor necrosis factor-α (TNF-α), IL-1β, IL-6 and chemokine including CXCL1, CXCL2 and CXCL10, elevated MHC I, MHC II and co-stimulatory molecules expression, and enhanced CD4+ and CD8+ T cell responses. Mechanistically, Viperin deficiency promoted DC activation and function through NF-κB p65 activation. NF-κB p65 inhibitor prevented cytokine and chemokine production, and co-stimulatory molecules expression promoted by Viperin deficiency.

Conclusions
These results suggest that Mtb induced Viperin expression could impair the activation of host defense function of DCs and DC-T cell cross talk during Mtb infection. This research may provide a potential target for future HDT in TB therapy.
Effects on beer colloidal stability of full-scale brewing with adjuncts, enzymes, and finings
Authors: Królak Kamil , Kobus Katarzyna , Kordialik-Bogacka Edyta 
Published: October 2022

AbstractThis study investigated the effects on beer colloidal stability of full-scale brewing with adjuncts, enzymes, and finings. Industrial lager beers were produced solely from barley malt or from barley malt with adjuncts (corn grist and starch syrup or unmalted barley). Various stabilization aids were also used (silica gel, PVPP, proline-specific endoprotease, carrageenan). Predictive shelf-life tests were conducted. We analyzed the content of compounds (proteins and polyphenols) generally related to beer colloidal stability. The results show that the haze-forming potential of the beer during storage can be evaluated based on the coagulable nitrogen content (high molecular weight proteins), rather than the total nitrogen content and polyphenol content. A very strong and statistically significant negative correlation was observed between the concentration of coagulable nitrogen and beer colloidal stability. When brewing was conducted with 49% barley raw material and exogenous proteases, especially proline-specific endoprotease, the coagulable nitrogen content fell and beer colloidal stability improved. The use of corn grist and starch syrup as up to 40% of the total grist resulted in a 30% longer physical shelf life compared to the all-malt beer.
Lymphodepleting chemotherapy practices and effect on safety and efficacy outcomes in patients with solid tumours undergoing T cell receptor-engineered T cell (TCR-T) Therapy: a systematic review and meta-analysis
Authors: Owen Kathryn , Ghaly Ramy , Shohdy Kyrillus S. , Thistlethwaite Fiona 
Published: October 2022

Abstract
Background
T cell receptor-engineered T cell (TCR-T) therapy has shown promising efficacy in advanced solid tumours. Lymphodepleting (LD) chemotherapy improves TCR-T cell therapy efficacy but is associated with significant toxicities. Evidence is sparse regarding the optimum LD regimen for TCR-T cell therapy in solid tumours.

Methods
A systematic review was conducted of interventional, prospective clinical trials describing LD practices prior to TCR-T cell therapy in patients with advanced solid tumours. The objective was to define LD regimens administered prior to TCR-T cell therapy and their effects on specific safety and efficacy outcomes in this patient population.

Results
Searches returned 484 studies, 19 (231 patients) met the eligibility criteria. Cyclophosphamide (cyclo) 60 mg/kg daily (2 days), plus fludarabine (fludara) 25 mg/m2 daily (5 days) was the most common LD regimen (38% of studies). Higher dose LD regimens were associated with increased pooled incidence rates of febrile neutropaenia compared to low dose (0.64, [95% Confidence interval (CI): 0.50–0.78], vs. 0.39 [95% CI: 0.25–0.53], respectively) but were not significantly associated with higher objective responses (odds ratio: 1.05, 95%CI: 0.60–1.82, p = 0.86). A major shortfall in safety data reporting was identified; determination of LD regimen effects on many safety outcomes was not possible.

Conclusion
Standard consensus guidelines for the design and reporting of adoptive cell therapy (ACT) studies would facilitate accurate risk–benefit analysis for optimising LD regimens in patients with advanced solid tumours.
The diagnostic performance of the ductus venosus for the detection of cardiac defects in the first trimester: a systematic review and diagnostic test accuracy meta-analysis
Authors: Savoia Fabiana , Scala Carolina , Coppola Marlene , Riemma Gaetano , Vitale Salvatore Giovanni , Mikuš Mislav , Schiattarella Antonio , La Verde Marco , Colacurci Nicola , De Franciscis Pasquale , Morlando Maddalena 
Published: October 2022

Abstract
Purpose
Abnormal flow in the ductus venosus (DV) has been reported to be associated with adverse perinatal outcome, chromosomal abnormalities, and congenital heart defects (CHD). Aneuploid fetuses have increased risk of CHD, but there are discrepancies on the performance of this markers in euploid fetuses. The aim of this meta-analysis was to establish the predictive accuracy of DV for CHD.

Methods
MEDLINE, EMBASE, and CINAHL were searched from inception to February 2022. No language or geographical restrictions were applied. Inclusion criteria regarded observational and randomized studies concerning first-trimester DV flow as CHD marker. Random effect meta-analyses to calculate risk ratio (RR) with 95% confidence interval (CI), hierarchical summary receiver-operating characteristics (HSROC), and bivariate models to evaluate diagnostic accuracy were used. Primary outcome was the diagnostic performance of DV in detecting prenatal CHD by means of area under the curve (AUROC). Subgroup analysis for euploid, high-risk, and normal NT fetuses was performed. Quality assessment of included papers was performed using QUADAS-2.

Results
Twenty two studies, with a total of 204.829 fetuses undergoing first trimester scan with DV Doppler evaluation, fulfilled the inclusion criteria for this systematic review. Overall, abnormal DV flow at the time of first trimester screening was associated to an increased risk of CHD (RR 6.9, 95% CI 3.7–12.6; I2 = 95.2%) as well in unselected (RR: 6.4, 95% CI 2.5–16.4; I2 = 93.3%) and in euploid (RR: 6.45, 95% CI 3.3–12.6; I2 = 95.8%) fetuses. The overall diagnostic accuracy of abnormal DV in detecting CHD was good in euploid fetuses with an AUROC of 0.81 (95% CI 0.78–0.84), but it was poor in the high-risk group with an AUROC of 0.66 (95% CI 0.62–0.70) and in the unselected population with an AUROC of 0.44 (95% CI 0.40–0.49).

Conclusions
Abnormal DV in the first trimester increases the risk of CHD with a moderate sensitivity for euploid fetuses. In combination with other markers (NT, TV regurgitation) could be helpful to identify fetuses otherwise considered to be at low risk for CHD. In addition to the improvement of the fetal heart examination in the first trimester, this strategy can increase the detection of major CHD at earlier stage of pregnancy.
Global solutions of aggregation equations and other flows with random diffusion
Authors: Rosenzweig Matthew , Staffilani Gigliola 
Published: October 2022

AbstractAggregation equations, such as the parabolic-elliptic Patlak–Keller–Segel model, are known to have an optimal threshold for global existence versus finite-time blow-up. In particular, if the diffusion is absent, then all smooth solutions with finite second moment can exist only locally in time. Nevertheless, one can ask whether global existence can be restored by adding a suitable noise to the equation, so that the dynamics are now stochastic. Inspired by the work of Buckmaster et al. (Int Math Res Not IMRN 23:9370–9385, 2020) showing that, with high probability, the inviscid SQG equation with random diffusion has global classical solutions, we investigate whether suitable random diffusion can restore global existence for a large class of active scalar equations in arbitrary dimension with possibly singular velocity fields. This class includes Hamiltonian flows, such as the SQG equation and its generalizations, and gradient flows, such as those arising in aggregation models. For this class, we show global existence of solutions in Gevrey-type Fourier–Lebesgue spaces with quantifiable high probability.
Outcomes of steroid-resistant nephrotic syndrome in children not treated with intensified immunosuppression
Authors: Trautmann Agnes , Seide Svenja , Lipska-Ziętkiewicz Beata S. , Ozaltin Fatih , Szczepanska Maria , Azocar Marta , Jankauskiene Augustina , Zurowska Alexandra , Caliskan Salim , Saeed Bassam , Morello William , Emma Francesco , Litwin Mieczyslaw , Tsygin Alexey , Fomina Svitlana , Wasilewska Anna , Melk Anette , Benetti Elisa , Gellermann Jutta , Stajic Natasa , Tkaczyk Marcin , Baiko Sergey , Prikhodina Larisa , Csaicsich Dagmar , Medynska Anna , Krisam Regina , Breitschwerdt Heike , Schaefer Franz ,   for the PodoNet Consortium
Published: October 2022

Abstract
Background
The aim of the current PodoNet registry analysis was to evaluate the outcome of steroid-resistant nephrotic syndrome (SRNS) in children who were not treated with intensified immunosuppression (IIS), focusing on the potential for spontaneous remission and the role of angiotensin blockade on proteinuria reduction.

Methods
Ninety-five pediatric patients who did not receive any IIS were identified in the PodoNet Registry. Competing risk analyses were performed on 67 patients with nephrotic-range proteinuria at disease onset to explore the cumulative rates of complete or partial remission or progression to kidney failure, stratified by underlying etiology (genetic vs. non-genetic SRNS). In addition, Cox proportional hazard analysis was performed to identify factors predicting proteinuria remission.

Results
Eighteen of 31 (58.1%) patients with non-genetic SRNS achieved complete remission without IIS, with a cumulative likelihood of 46.2% at 1 year and 57.7% at 2 years. Remission was sustained in 11 children, and only two progressed to kidney failure. In the genetic subgroup (n = 27), complete resolution of proteinuria occurred very rarely and was never sustained; 6 (21.7%) children progressed to kidney failure at 3 years. Almost all children (96.8%) received proteinuria-lowering renin–angiotensin–aldosterone system (RAAS) antagonist treatment. On antiproteinuric treatment, partial remission was achieved in 7 of 31 (22.6%) children with non-genetic SRNS and 9 of 27 children (33.3%) with genetic SRNS.

Conclusion
Our results demonstrate that spontaneous complete remission can occur in a substantial fraction of children with non-genetic SRNS and milder clinical phenotype. RAAS blockade increases the likelihood of partial remission of proteinuria in all forms of SRNS.

Graphical abstract
What do Members of Parliament in India Think of Robots? Validation of the Frankenstein Syndrome Questionnaire and Comparison with Other Population Groups
Authors: Bharatharaj Jaishankar , Sasthan Kutty Senthil Kumar , Munisamy Achudhan , Krägeloh Christian U. 
Published: October 2022

AbstractIndia is the second largest country in the world in terms of population and thus a considerable market for potential future robot applications as well as a location for manufacturing and production. While work has started to explore attitudes towards robots, very little is known about the perceptions of robots in India, particularly of political leaders who have the ability to effect rapid change. The present study administered the 30-item Frankenstein Syndrome Questionnaire to 31 Lok Sabha (Lower House) and Rajya Sabah (Upper House) members of the Indian Parliament (MPs) as well as doctors (n = 94), medical students (n = 493), and engineering students (n = 1104) for comparative purposes. Because no information had been available about the psychometric properties of the scale for use in India, a prior Rasch analysis explored the suitability of the commonly used five-factor model. The five subscales did not possess sufficient reliability, and a more psychometrically robust 26-item two-factor model (positive and negative attitudes) was utilized instead. The results revealed a higher degree of positive attitudes in MPs and doctors as compared to the two student groups. Negative attitudes, on the other hand, were strongest in doctors, followed by students. MPs had significantly less negative views compared to all other comparison groups. This study provides valuable insights into attitudes towards robots in India. In general, MPs appear to have more favourable views than comparison groups in India. A slightly shorter and more parsimonious version of the Frankenstein Syndrome Questionnaire has now also been proposed, with improved psychometric properties.
Research and application of acid fracturing stimulation mechanism in ultra-deep subsalt dolomite reservoir in Tarim Basin
Authors: Liu Jiangyu , Zhao Jinming , Qin Shiyong , Zhang Nanlin , Ren Dengfeng , Luo Zhifeng , Xie Yaozeng 
Published: October 2022

AbstractDeep and ultra-deep carbonate reservoirs are the focus of exploration and development in future. However, the problems of high pressures in the treatment process, a limited effective etching distance of acid, great acid leak-off, and poor adaptability of the acid system are encountered in this type of oil and gas reservoir. The mechanism of acid fracturing stimulation under different processes and parameters is not clear. Aiming at these issues, the treatment schemes, process optimization, parameter optimization, and liquid system screening are studied in this paper, try to clarify the acid fracturing stimulation mechanism, and the following conclusions are drawn: The acid network fracturing could activate natural fracture to generate a complex fracture network to the greatest extent, and thereby a high output could be achieved; By using of weighted fracturing fluid, the wellhead injection pressure, as well as the performance of equipment required, could be effectively reduced; With 20% gelling acid and 20% retarded acid system, the non-uniform etching could be realized to improve the effective etching distance of acid liquid. The conclusions in this paper shed light on the acid fracturing treatment of deep and ultra-deep carbonate rocks.
Die aktuelle Situation der kinder- und jugendpsychiatrischen Versorgung in Österreich im niedergelassenen Bereich
Authors: Koubek Doris , Krönke Helmut , Karwautz Andreas 
Published: October 2022

ZusammenfassungDie kinder- und jugendpsychiatrische Versorgungslage in Österreich ist noch unvollständig und im Aufbau seit das Sonderfach gegründet wurde. Die Coronapandemie führt zu einem weiter erhöhten Versorgungsdruck auf die bestehenden Strukturen.In dieser Arbeit soll der Status quo in der ambulanten Versorgung im niedergelassenen kassenärztlichen Bereich erhoben und zusammengefasst werden. Ein IST-Soll Vergleich soll die Defizite und Entwicklungsnotwendigkeiten aktuell dokumentieren.Die 9 Bundesländer Österreichs sind bisher unterschiedlich weit in der Umsetzung einer Gesamtversorgung. Wir schließen mit Empfehlungen zur Umsetzung.
Francisco De Vitoria on the Nature and Source of Civil Authority
Authors: Osborne Thomas M. 
Published: October 2022

AbstractReaders have found at least two distinct and perhaps contradictory accounts of civil authority in the works of Francisco de Vitoria, and some hold that Vitoria himself holds contradictory positions. This article argues that Vitoria holds one consistent position, namely, that civil power is based on a necessity that is rooted in human nature, and in particular on the final cause of human life, and not on a necessity that is a result of any historical decision or process on its own. Rulers receive from the community their authority, which is a power to act on behalf of that community. Scholars have failed to consider how Vitoria's understanding of civil power is Aristotelian and Thomistic to the extent that it is based on the thesis that the political community is natural in a way similar to how families and individuals are natural.
Jerome of Moray: a Scottish Dominican and the evolution of Parisian music theory 1220–1280
Authors: MEWS CONSTANT J. 
Published: October 2022

ABSTRACTThis article examines the Tractatus de musica of Jerome of Moray (‘de Moravia’), affirming his Scottish identity, as proposed by Michel Huglo in 1994. It argues that the Tractatus de musica presents an important overview of Parisian music theory in the thirteenth century, relating to both chant and mensurable music in that century, because it combines the views of several generations: the Positio discantus vulgaris, which he says was used ‘among the nations’; the De mensurabili musica of John of Garland, who corrected its deficiencies; and the treatises of Franco of Cologne and Petrus Picardus. It considers Jerome's career in three phases: his exposure to music and music theory in Scotland; his studies in Paris, most likely under John of Garland, perhaps at the cathedral school of Notre-Dame; and his involvement in the liturgical reforms within the Dominican Order, implemented by its Master, Humbert of Romans in 1256. Rather than assigning Franco's Ars cantus mensurabilis to 1280 (as proposed by Wolf Frobenius) and Jerome's Tractatus to sometime after this, I suggest that Jerome was exposed to John of Garland's teaching in the 1240s and that the Franconian system may have started to gain ground in the 1250s. Jerome compiled his Tractatus over a period of time, adding an excerpt about cosmic music from the commentary of Thomas Aquinas on Aristotle's De caelo perhaps as early as 1271 or 1272, in response to the criticisms of John of Garland and his followers being made by Johannes de Grocheio.
Hidden colouration: deep metrical flexibility in Machaut
Authors: LAVACEK JUSTIN 
Published: October 2022

ABSTRACTThis article introduces a metrical adaptation to the contrapunctus method of pitch reduction commonly used to analyse Ars Nova counterpoint. Expanding the medieval concept of colouration from the mensural to the metrical, my contrapuncti highlight the flexible toggling between perfect and imperfect groupings at various rhythmic levels in selected motets by Guillaume de Machaut (c.1300–77). The viewpoint advanced here assumes no a priori metrical grid to parse the musical surface, but rather allows the articulation of sonority, cadence and form to reveal a fluid and unique metrical grouping structure for each piece. With metrical emphases shown as inextricable from contrapuntal and harmonic ones, the metrical contrapunctus captures a more comprehensive picture of Machaut's musical language.
Multi‐Stage Evolution of the South Australian Craton: Petrological Constraints on the Architecture, Lithology, and Geochemistry of the Lithospheric Mantle
Authors: Sudholz Z. J. , Yaxley G. M. , Jaques A. L. , Cooper S. A. , Czarnota K. , Taylor W. R. , Chen J. , Knowles B. M. 
Published: October 2022

AbstractTo improve the understanding of the formation and evolution of the sub‐continental lithospheric mantle (SCLM) underlying the South Australian Craton we have conducted a detailed petrological study on >3,000 mantle xenocrysts from 13 kimberlites emplaced across the craton. Pressure (P) and temperature (T) estimates on Cr diopside and garnet have been coupled with their chemical concentrations to constrain lithospheric thickness and chemo‐lithostratigraphy. We show that lithospheric thickness is greatest beneath the Gawler Craton, whereas thinner lithosphere occurs beneath the Adelaide Fold Belt. Mineral compositions highlight two litho‐chemical domains within the shallow and deep SCLM that are separated by a mid‐lithosphere discontinuity (MLD). The shallow SCLM (60–130 km) comprises low Cr2O3 lherzolite and wehrlite. Shallow SCLM xenocrysts record depleted and refertilized compositions enriched in light rare earth elements related to metasomatism by kimberlite or related melts. The mid‐lithosphere (130–160 km) is depleted in garnet and Cr diopside which may relate to a layer of pargasite lherzolite. The deep SCLM (>160 km) comprises high Cr2O3 lherzolite with elevated TiO2 and FeO. We interpret the litho‐chemical stratification of the SCLM to reflect a multi‐stage top‐down growth. The shallow SCLM reflects an amalgamation of Precambrian cratonic nuclei characterized by heterogeneity in geochemical enrichment and depletion. Interaction of the shallow SCLM with mantle plumes accreted melts along the paleo‐lithosphere‐asthenosphere boundary, which now occurs as a MLD. The deep SCLM represents depleted mantle residue formed during mantle plume impingement and thickened during orogenesis. This domain has been metasomatized and refertilized by high‐T melts from the asthenosphere.