bluuebunny/crossref_metadata_2025_split huggingface dataset:
What are the respiratory health research priorities in Alberta, Canada? A stakeholder consultation
Authors: Sharpe Heather , Cerato Lisa , Derech Darlene , Guirguis Lisa , Hayward Kathleen , Lohmann Tara , MacLean Joanna E , Manafo Elizabeth , Paskey Janice , Rasiah Jananee , Rimkus Mark , Rizvi Syeda Kinza , Robinson Gerry , Seefried Brent , Somani Zeeyaan , Tindall Mindy , Vliagoftis Harissios , Pendharkar Sachin R , Stickland Michael K 
Published: June 2022

ObjectiveThe Respiratory Health Strategic Clinical Network (RHSCN) was launched to facilitate respiratory and sleep health through implementation of innovative, patient-centred, evidence-informed coordinated services in Alberta. In collaboration with project partners, the RHSCN aimed to determine the respiratory research priorities for Alberta.DesignThe four phases of this research prioritisation project were (1) identifying research questions from stakeholders, (2) determining which research questions had been answered in existing literature, (3) prioritising unanswered questions and (4) finalising the priorities through an inperson workshop.SettingThe study occurred in Alberta, Canada over a 2-year period beginning in March 2017.ParticipantsA total of 448 patients, clinicians and other stakeholders consented to participate in the survey.ResultsA total of 595 possible questions were submitted, with 343 unique questions identified. Of the questions, 94 were out of scope, 155 answered by existing literature and 10 were combined with others, while 83 were determined to be unanswered in the literature. Stakeholders were surveyed again to prioritise the remaining 83 questions and they were reviewed by the project’s Steering Committee (clinicians and patients). At the inperson workshop, the Steering Committee identified 17 research topics as priority areas for respiratory and sleep research in Alberta.ConclusionA stakeholder-led research prioritisation process identified optimal clinical management/follow-up, equitable access to services, and management of social, psychological and mental health issues related to respiratory/sleep health as priority research areas.
Augmenting neurocognitive remediation therapy to Preventive Cognitive Therapy for partially remitted depressed patients: protocol of a pragmatic multicentre randomised controlled trial
Authors: Bockting Claudi , Legemaat Amanda M , van der Stappen Johanne G J , Geurtsen Gert J , Semkovska Maria , Burger Huibert , Bergfeld Isidoor O , Lous Nicoline , Denys Damiaan A J P , Brouwer Marlies 
Published: June 2022

IntroductionMajor depressive disorder (MDD) affects 163 million people globally every year. Individuals who experience subsyndromal depressive symptoms during remission (ie, partial remission of MDD) are especially at risk for a return to a depressive episode within an average of 4 months. Simultaneously, partial remission of MDD is associated with work and (psycho)social impairment and a lower quality of life. Brief psychological interventions such as preventive cognitive therapy (PCT) can reduce depressive symptoms or relapse for patients in partial remission, although achieving full remission with treatment is still a clinical challenge. Treatment might be more effective if cognitive functioning of patients is targeted as well since cognitive problems are the most persisting symptom in partial remission and predict poor treatment response and worse functioning. Studies show that cognitive functioning of patients with (remitted) MDD can be improved by online neurocognitive remediation therapy (oNCRT). Augmenting oNCRT to PCT might improve treatment effects for these patients by strengthening their cognitive functioning alongside a psychological intervention.Methods and analysisThis study will examine the effectiveness of augmenting oNCRT to PCT in a pragmatic national multicentre superiority randomised controlled trial. We will include 115 adults partially remitted from MDD with subsyndromal depressive symptoms defined as a Hamilton Depression Rating Scale score between 8 and 15. Participants will be randomly allocated to PCT with oNCRT, or PCT only. Primary outcome measure is the effect on depressive symptomatology over 1 year. Secondary outcomes include time to relapse, cognitive functioning, quality of life and healthcare costs. This first dual approach study of augmenting oNCRT to PCT might facilitate full remission in partially remitted individuals as well as prevent relapse over time.Ethics and disseminationEthical approval was obtained by Academic Medical Center, Amsterdam. Outcomes will be made publicly available.Trial registration numberNL9582.
Contact investigation of tuberculosis in Brunei Darussalam: Evaluation and risk factor analysis
Authors: Chaw Liling , Abdul Hamid Rafizah , Koh Kai Shing , Thu Kyaw 
Published: June 2022

IntroductionWe evaluated the yield of tuberculosis (TB) contact investigation in Brunei Darussalam, and identified the associated factors for latent TB infection (LTBI) diagnosis, as well as for initiating and completing LTBI treatment.MethodsData were extracted and digitalised for all close contacts of pulmonary TB (PTB) cases at the National TB Coordinating Centre from January 2009 to December 2018. Generalising estimating equations logistic regression models were used to determine the associated factors. Manual matching against electronic health records system was done to identify contacts who had progressed to active TB disease.ResultsAmong 10 537 contacts, 9.9% (n=1047) were diagnosed as LTBI, out of which 43.0% (n=450) initiated LTBI treatment. Among those who initiated, 74.0% (n=333) completed LTBI treatment. Contact factors associated with LTBI diagnosis include being male (adjusted OR (aOR)=1.18 (95% CI 1.03 to 1.34)), local (aOR=0.70 (95% CI 0.56 to 0.88)) and a household contact (aOR=1.59 (95% CI 1.26 to 1.99)). Contacts of index cases who were <60 years old and diagnosed as smear positive PTB (aOR=1.62 (95% CI 1.19 to 2.20)) had higher odds of being diagnosed with LTBI. Local LTBI cases had higher odds of initiating LTBI treatment (aOR=1.86 (95% CI 1.26 to 2.73)). Also, LTBI cases detected from local (aOR=2.32 (95% CI 1.08 to 4.97)) and smear positive PTB index cases (aOR=2.23 (95% CI 1.09 to 4.55)) had higher odds of completing LTBI treatment. Among 1047 LTBI cases, 5 (0.5%) had progressed to active PTB within 1–8 years post-LTBI diagnosis.DiscussionLTBI burden is disproportionately high towards foreign nationals, with higher odds of LTBI diagnosis but lower odds of treatment initiation. Determining the reasons of not initiating LTBI treatment will be useful to help improve LTBI treatment uptake. Establishing digital databases and building TB laboratory capacity for molecular typing would be useful to determine the contribution of LTBI or reactivation towards TB incidence in Brunei.
Early-life exposure to economic stress and metabolic risks in young adulthood: the children of the reunification in East Germany
Authors: Bister Lara , Janssen Fanny , Vogt Tobias 
Published: June 2022

BackgroundResearch on the long-term health consequences of early-life exposure to economic crises is scarce. We examine for the first time the long-term effects of early-life exposure to an economic crisis on metabolic health risks. We study objective health measures, and exploit the quasi-experimental situation of the postreunification economic crisis in East Germany.MethodsData were drawn from two waves of the longitudinal German Health Interview and Examination Survey for Children and Adolescents (2003–2006, 2014–2017). We compared 392 East Germans who were exposed to the economic crisis in utero and at ages 0–5 with 1123 of their West German counterparts using propensity score matching on individual and family characteristics. We assessed blood pressure, cholesterol, blood fat and body mass index (BMI); both combined as above-average metabolic health risks and individually at ages 19–30.ResultsEarly-life exposure to the economic crisis significantly increased the number of above-average metabolic health risks in young adulthood by 0.1482 (95% CI 0.0169 to 0.2796), which was 5.8% higher compared with no exposure. Among individuals exposed in utero, only females showed significant effects. Early-life exposure to the economic crisis was associated with increased systolic (0.9969, 95% CI −0.2806 to 2.2743) and diastolic blood pressure (0.6786, 95% CI −0.0802 to 1.4373), and with increased BMI (0.0245, 95% CI −0.6516 to 0.7001).ConclusionThe increased metabolic health risks found for women exposed to the postreunification economic crisis in-utero are likely attributable to increased economic stress. While the observed differences are small, they may foreshadow the emergence of greater health disparities in older age.
Community participation in coastal and marine research and monitoring in Inuit Nunangat: a scoping literature review
Authors: Drake A.K. , Perkovic A. , Reeve C. , Alexander S.M. , Nguyen V.M. , Dunmall K.M. 
Published: June 2022

In Canada, the participation of Indigenous communities in research and monitoring is growing in response to calls for partnerships and heightened interest in bridging Indigenous and Western science-based knowledge. Yet, as settler scholars, we have noted inconsistencies in the articulation and operationalization of community participation in peer-reviewed literature. We conducted a scoping review of community participation in coastal and marine research and monitoring across Inuit Nunangat. This resulted in 72 studies, most of which were undertaken in Nunavut. Fourteen terms were used to articulate community participation, the most common being: participate, collaborate, community-based, consult, or variations of these terms. Among the studies that used community participation terms, we found that authors only defined terms 10% of the time. Community participation was operationalized primarily through interviews, mapping, and field observations. We assessed studies across a spectrum of community participation levels and found that most studies (81%) reflected minimal levels of participation (i.e., consultative, contractual, and less than contractual). Our results highlight the need for clarity in language use, transparency in reporting research practices, and stronger efforts to support Indigenous leadership and decision-making authority, all of which must be defined on a community or project basis.
Mineralogy and K–Ar geochronology of clay alteration associated with uranium mineralization in the Patterson Lake Corridor, Saskatchewan
Authors: Powell Jeremy W. , Percival Jeanne B. , Potter Eric G. , van der Lelij Roelant , Xie Ruikai 
Published: June 2022

The Patterson Lake Corridor (PLC) along the southwestern margin of the Athabasca Basin contains high-grade uranium deposits entirely within crystalline basement rocks. Visible–near infrared–shortwave infrared (VNIR–SWIR) spectroscopy measurements were collected on drill core samples from several locations in the PLC. The Triple R and Arrow deposits exhibit downhole spectral trends related to the crystallinity and thermal maturity of clays (illite and kaolinite) and mineralization. The K–Ar dates of silt-and-clay size fractions (10–6

μ

m; 6–2

μ

m; 2–0.6

μ

m; 0.6–0.2

μ

m; <0.2

μ

m) from five clay-altered samples decrease with grain size, and span 1608 ± 17 Ma to 1060 ± 14 Ma for the Spitfire discovery (
n
= 14) and 1342 ± 17 Ma to 289 ± 4.3 Ma for the Arrow deposit (
n
= 4). Alteration assemblages are broadly similar to Athabasca Basin basement-hosted deposits, and K–Ar dates indicate that high-grade uranium mineralization in the PLC reflects remobilization and concentration of primary ores. Integration of geochronology, clay mineralogy and VNIR–SWIR spectral parameters identify fertile fluid conduits when expanded to property or corridor scales, and provide additional evidence that ore grades of the Athabasca Basin deposits reflect several stages of hydrothermal mineralization spanning
c.
1000 Ma.

Supplementary material:
Supporting information document and datasets are available at
https://doi.org/10.6084/m9.figshare.c.6033890

Thematic collection:
This article is part of the Uranium Fluid Pathways collection available at:
https://www.lyellcollection.org/cc/uranium-fluid-pathways
Reproducibility of the Blood and Urine Exposome: A Systematic Literature Review and Meta-Analysis
Authors: Goerdten Jantje , Yuan Li , Huybrechts Inge , Neveu Vanessa , Nöthlings Ute , Ahrens Wolfgang , Scalbert Augustin , Floegel Anna 
Published: June 2022

Abstract

Endogenous and exogenous metabolite concentrations may be susceptible to variation over time. This variability can lead to misclassification of exposure levels and in turn to biased results. To assess the reproducibility of metabolites, the intraclass correlation coefficient (ICC) is computed. A literature search in three databases from 2000 to May 2021 was conducted to identify studies reporting ICCs for blood and urine metabolites. This review includes 192 studies, of which 31 studies are included in the meta-analyses. The ICCs of 359 single metabolites are reported, and the ICCs of 10 metabolites were meta-analyzed. The reproducibility of the single metabolites ranges from poor to excellent and is highly compound-dependent. The reproducibility of bisphenol A (BPA), mono-ethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-2-ethylhexyl phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-benzyl phthalate (MBzP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), methylparaben, and propylparaben is poor to moderate (ICC median: 0.32; range: 0.15–0.49), and for 25-hydroxyvitamin D [25(OH)D], it is excellent (ICC: 0.95; 95% CI, 0.90–0.99). Pharmacokinetics, mainly the half-life of elimination and exposure patterns, can explain reproducibility. This review describes the reproducibility of the blood and urine exposome, provides a vast dataset of ICC estimates, and hence constitutes a valuable resource for future reproducibility and clinical epidemiologic studies.
Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain
Authors: Buonato Janine M. , Edwards Justin P. , Zaritskaya Liubov , Witter Alexandra R. , Gupta Ankit , LaFleur David W. , Tice David A. , Richman Laura K. , Hilbert David M. 
Published: June 2022

Abstract
Chimeric antigen receptor (CAR) T-cell therapies directed against B-cell maturation antigen (BCMA) have shown compelling clinical activity and manageable safety in subjects with relapsed and refractory multiple myeloma (RRMM). Prior reported CAR T cells have mostly used antibody fragments such as humanized or murine single-chain variable fragments or camelid heavy-chain antibody fragments as the antigen recognition motif. Herein, we describe the generation and preclinical evaluation of ddBCMA CAR, which uses a novel BCMA binding domain discovered from our D domain phage display libraries and incorporates a 4-1BB costimulatory motif and CD3-zeta T-cell activation domain. Preclinical in vitro studies of ddBCMA CAR T cells cocultured with BCMA-positive cell lines showed highly potent, dose-dependent measures of cytotoxicity, cytokine production, T-cell degranulation, and T-cell proliferation. In each assay, ddBCMA CAR performed as well as the BCMA-directed scFv-based C11D5.3 CAR. Furthermore, ddBCMA CAR T cells demonstrated in vivo tumor suppression in three disseminated BCMA-expressing tumor models in NSG-immunocompromised mice. On the basis of these promising preclinical data, CART-ddBCMA is being studied in a first-in-human phase I clinical study to assess the safety, pharmacokinetics, immunogenicity, efficacy, and duration of effect for patients with RRMM (NCT04155749).
In VitroInsertional Mutagenesis Screen Identifies Novel Genes Driving Breast Cancer Metastasis
Authors: Miskey Csaba , Botezatu Lacramioara , Temiz Nuri A. , Gogol-Döring Andreas , Bartha Áron , Győrffy Balázs , Largaespada David A. , Ivics Zoltán , Sebe Attila 
Published: June 2022

AbstractMetastasis, a complex, multistep process, is responsible for the overwhelming majority of cancer-related deaths. Despite its devastating consequences, it is not possible to effectively treat cancer that has spread to vital organs, the mechanisms leading to metastasis are still poorly understood, and the catalog of metastasis promoting genes is still incomprehensive. To identify new driver genes of metastasis development, we performed an in vitro Sleeping Beauty transposon-based forward genetic screen in nonmetastatic SKBR3 human breast cancer cells. Boyden chamber-based matrix invasion assays were used to harvest cells that acquired a de novo invasive phenotype. Using targeted RNA sequencing data from 18 pools of invasive cells, we carried out a gene-centric candidate gene prediction and identified established and novel metastasis driver genes. Analysis of these genes revealed their association with metastasis related processes and we further established their clinical relevance in metastatic breast cancer. Two novel candidate genes, G protein–coupled receptor kinase interacting ArfGAP 2 (GIT2) and muscle-associated receptor tyrosine kinase (MUSK), were functionally validated as metastasis driver genes in a series of in vitro and in vivo experimental metastasis models. We propose that our robust and scalable approach will be a useful addition to the toolkit of methodologic resources used to identify genes driving cancer metastasis.Implications:Novel metastasis drivers were identified in a human breast cancer cell line by performing an in vitro, Sleeping Beauty transposon-based forward genetic screen and an RNA fusion-based candidate gene prediction.
Stroke Outcomes in Women: A Population-Based Cohort Study
Authors: Xu Min , Amarilla Vallejo Adriana , Cantalapiedra Calvete Clara , Rudd Anthony , Wolfe Charles , O’Connell Matthew D.L. , Douiri Abdel 
Published: June 2022

Background:
Limited data are available on sex-related disparities in long-term outcomes after stroke. We estimated sex differences in various stroke long-term outcomes among survivors after stroke in a prospective 25-year follow-up study.

Methods:
Individuals recruited to the South London Stroke Register, an ongoing multi-ethnic urban-based population stroke register, from 1995 onward were included in the analyses (n=6687). The outcomes were death, subsequent stroke, activity of daily living, instrumental activity of daily living, cognitive impairment, depression, anxiety, and health-related quality of life. Kaplan-Meier curves were generated for mortality, stroke recurrence, and recurrence-free survival by sex and Cox proportional hazards model used to model sex differences up to 25 years. Generalized estimating equation were used to model sex differences in risk of self-reported stroke outcomes over 10 years poststroke outcomes, adjusting for age, preexisting activity of daily living, case-mix, stroke subtypes, and other potential confounding risk factors.

Results:
There were 49% women (mean age, 72 years; SD, 15.6) and 51% men (mean age, 67 years; SD, 14.3) in 6687 participants. Compared with men, women had 9% (95% CI, 3%–15%) lower covariate-adjusted risk of death and 6% (0%–13%) lower risk of stroke recurrence or death. Generally, women had significantly poorer outcomes in activity of daily living and anxiety than men, and the sex differences persisted to up to 5 years after stroke. Women also had poorer health-related quality of life in physical (β=−2.06 [95% CI, −3.01 to −1.10]) and mental domains (β=−1.48 [95% CI, −2.44 to −0.52]). Although not significant, there was a suggestive trend for poorer outcomes in cognitive impairment and depression in women. No significant difference in stroke recurrence were found between men and women.

Conclusions:
Female patients with stroke tended to have better covariate-adjusted survival but poorer outcomes among survivors than male patients, with deficits persisting to up to 5 years poststroke.
Intravenous tPA (Tissue-Type Plasminogen Activator) Correlates With Favorable Venous Outflow Profiles in Acute Ischemic Stroke
Authors: Faizy Tobias D. , Mlynash Michael , Marks Michael P. , Christensen Soren , Kabiri Reza , Kuraitis Gabriella M. , Broocks Gabriel , Winkelmeier Laurens , Geest Vincent , Nawabi Jawed , Lansberg Maarten G. , Albers Gregory W. , Fiehler Jens , Wintermark Max , Heit Jeremy J. 
Published: June 2022

Background:
Intravenous tPA (tissue-type plasminogen activator) is often administered before endovascular thrombectomy (EVT). Recent studies have questioned whether tPA is necessary given the high rates of arterial recanalization achieved by EVT, but whether tPA impacts venous outflow (VO) is unknown. We investigated whether tPA improves VO profiles on baseline computed tomography (CT) angiography (CTA) images before EVT.

Methods:
Retrospective multicenter cohort study of patients with acute ischemic stroke due to large vessel occlusion undergoing EVT triage. Included patients underwent CT, CTA, and CT perfusion before EVT. VO profiles were determined by opacification of the vein of Labbé, sphenoparietal sinus, and superficial middle cerebral vein on CTA as 0, not visible; 1, moderate opacification; and 2, full. Pial arterial collaterals were graded on CTA, and tissue-level collaterals were assessed on CT perfusion using the hypoperfusion intensity ratio. Clinical and demographic data were determined from the electronic medical record. Using multivariable regression analysis, we determined the correlation between tPA administration and favorable VO profiles.

Results:

Seven hundred seventeen patients met inclusion criteria. Three hundred sixty-five patients received tPA (tPA+), while 352 patients were not treated with tPA (tPA−). Fewer tPA+ patients had atrial fibrillation (n=128 [35%] versus n=156 [44%];
P
=0.012) and anticoagulants/antiplatelet treatment before acute ischemic stroke due to large vessel occlusion onset (n=130 [36%] versus n=178 [52%];
P
<0.001) compared with tPA− patients. One hundred eighty-five patients (51%) in the tPA+ and 100 patients (28%) in the tPA− group exhibited favorable VO (
P
<0.001). Multivariable regression analysis showed that tPA administration was a strong independent predictor of favorable VO profiles (OR, 2.6 [95% CI, 1.7–4.0];
P
<0.001) after control for favorable pial arterial CTA collaterals, favorable tissue-level collaterals on CT perfusion, age, presentation National Institutes of Health Stroke Scale, antiplatelet/anticoagulant treatment, history of atrial fibrillation and time from symptom onset to imaging.

Conclusions:
In patients with acute ischemic stroke due to large vessel occlusion undergoing thrombectomy triage, tPA administration was strongly associated with the presence of favorable VO profiles.
Assessing the quality of media reporting of suicide deaths in Pakistan against international guidelines
Authors: Ayub Maryam , Rafiq Bariah , Tahir Sania Mumtaz , Imran Nazish , Naveed Sadiq , Haider Imran Ijaz 
Published: June 2022

Background: In Pakistan, there is lack of official suicide data due to associated stigma and socio-cultural factors. Although, suicide incidents are regularly reported in newspapers there are no official suicide reporting guidelines. Aims: The aim was to study the quality of suicide reporting in Pakistani newspapers and compare it to international media guidelines. Method: Newspaper reports on suicide deaths were searched in four Pakistani national newspapers from 1st January 2019 to 31st December 2020. Data was extracted using templates based on World Health Organization and Reporting on Suicide media guidelines. Results: There were total 2,295 suicides reported in 2 years. The word ‘suicide’ was mentioned in title of 2,113 (92.06%) reports. In 70.37% news articles, motive for suicide was reduced to a single factor. Method was mentioned in 95.6% suicides. Pictures accompanied 103 (4.4%) news reports. Only 13 (0.57%) the news stories recognized the link between substance abuse and suicide. None of the reports provided education to public about suicide or mentioned resources to seek help. Conclusions: The articles reporting on suicide deaths were regularly featured in Pakistani newspapers with strikingly low level of adherence to suicide reporting guidelines.