bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing the dynamic response of protective structures within heavy-duty vehicles in complex transportation conditions
Authors: Su Yi , Zou Jun , Li Zhong Yi , Lu Wei 
Published: October 2022

This paper develops a simulated dynamics model focused on the vibration coupling between a heavy-duty vehicle and the protective structure of the payload and verifies it through field experiments, which monitor the dynamic response under complex driving conditions such as uneven surfaces, turning, deceleration, and excessive gradients in real time. Compared with the results of the experiments and the simulations (with numerical methods), it can be found that the model can accurately estimate dynamic response of protective structures. The maximum acceleration at the bottom of the protective structure becomes larger as the amplitude of the road surface roughness increases. Furthermore, when the vehicle turns, the vibration of the protective structure increases sharply with braking, and when the vehicle begins decelerating, the lateral acceleration of the freight increases significantly in the first few seconds. In addition, the maximum acceleration at the bottom of the protective structure increases with the increase in speed when the heavy-duty vehicle is driving on a gradient, but that increase is small when the speed exceeds 80 km/h.
Impact of Birthing Room Design on Maternal Childbirth Experience: Results From the Room4Birth Randomized Trial
Authors: Goldkuhl Lisa , Gyllensten Hanna , Begley Cecily , Nilsson Christina , Wijk Helle , Lindahl Göran , Uvnäs-Moberg Kerstin , Berg Marie 
Published: October 2022

Objective: To study the effect of the birthing room design on nulliparous women’s childbirth experience up to 1 year after birth. Background: Although it is known that the birth environment can support or hinder birth processes, the impact of the birthing room design on maternal childbirth experience over time is insufficiently studied. Methods: The Room4Birth randomized controlled trial was conducted at a labor ward in Sweden. Nulliparous women in active stage of spontaneous labor were randomized ( n = 406) to either a regular birthing room ( n = 202) or a new birthing room designed with more person-centered considerations ( n = 204). Childbirth experiences were measured 2 hr, 3 months, and 12 months after birth by using a Visual Analogue Scale of Overall Childbirth Experience (VAS-OCE), the Fear of Birth Scale (FOBS), and the Childbirth Experience Questionnaire (CEQ2). Results: Women randomized to the new room had a more positive childbirth experience reported on the VAS-OCE 3 months ( p = .002) and 12 months ( p = .021) after birth compared to women randomized to a regular room. Women in the new room also scored higher in the total CEQ2 score ( p = .039) and within the CEQ2 subdomain own capacity after 3 months ( p = .028). The remaining CEQ2 domains and the FOBS scores did not differ between the groups. Conclusions: These findings show that a birthing room offering more possibilities to change features and functions in the room according to personal needs and requirements, positively affects the childbirth experience of nulliparous women 3 and 12 months after they have given birth.
Anabolic Response of Intermittent Parathyroid Hormone and Alendronate on the Osteochondral Tissue of TMJ
Authors: Chen Po-Jung , Wang Ke , Mehta Shivam , O’Brien Mara H. , Dealy Caroline N. , Dutra Eliane H. , Yadav Sumit 
Published: October 2022

Objective To characterize the effects of parathyroid hormone (PTH) and alendronate (Alend) on the osteochondral tissue of temporomandibular joint (TMJ). Materials and Methods Ninety-six male and female transgenic reporter mice, 4 to 5 weeks old were divided into 6 groups: (1) Control group: Saline was injected daily for 14 days; (2) PTH: PTH was injected daily for 14 days; (3) Alend: Alend was injected every alternate days for 14 days; (4) Combined PTH and Alend: PTH was injected daily and Alend injected every alternate days for 14 days; (5) PTH then Alend: PTH was injected daily for 14 days followed by Alend injections in alternate days for 14 days; and (6) PTH wait Alend: PTH was injected daily for 14 days. There was a waiting period of 1 week before administration of Alend in alternate days for 14 days. Mice were injected with 5-ethnyl-2′-deoxyuridine (EdU), 48 and 24 hours prior to euthanization. Results There was significant increase in bone volume and decrease in osteoclastic activity in groups in which Alend was administered after PTH in both gender. There was significant increase in cartilage thickness with PTH or Alend alone in females, whereas in males, PTH alone led to increase in cartilage thickness. Chondrocyte apoptosis was significantly decreased with PTH or Alend alone in both male and female. Matrix metallopeptidase 13, and aggreganase-2 (ADAMTS5) expression were significantly decreased with PTH and Alend alone in both gender. Conclusion PTH and Alend administration causes anabolic effects in the osteochondral tissue of TMJ.
Changes in the Cross-Sectional Profile of Treated Anterior Cruciate Ligament Within 2 Years After Surgery
Authors: Menghini Danilo , Kaushal Shankar G. , Flannery Sean W. , Ecklund Kirsten ,   BEAR Trial Team, Murray Martha M. , Fleming Braden C. , Kiapour Ata M. , Proffen Benedikt , Sant Nicholas , Portilla Gabriela , Sanborn Ryan , Freiberger Christina , Henderson Rachael , Barnett Samuel , Yen Yi-Meng , Kramer Dennis E. , Micheli Lyle J. 
Published: October 2022

Background: The cross-sectional area (CSA) of the anterior cruciate ligament (ACL) and reconstructed graft has direct implications on its strength and knee function. Little is known regarding how the CSA changes along the ligament length and how those changes vary between treated and native ligaments over time. Hypothesis: It was hypothesized that (1) the CSA of reconstructed ACLs and restored ACLs via bridge-enhanced ACL restoration (BEAR) is heterogeneous along the length. (2) Differences in CSA between treated and native ACLs decrease over time. (3) CSA of the surgically treated ACLs is correlated significantly with body size (ie, height, weight, body mass index) and knee size (ie, bicondylar and notch width). Study Design: Cohort study; Level of evidence, 2. Methods: Magnetic resonance imaging scans of treated and contralateral knees of 98 patients (n = 33 ACL reconstruction, 65 BEAR) at 6, 12, and 24 months post-operation were used to measure the ligament CSA at 1% increments along the ACL length (tibial insertion, 0%; femoral insertion, 100%). Statistical parametric mapping was used to evaluate the differences in CSA between 6 and 24 months. Correlations between body and knee size and treated ligament CSA along its length were also assessed. Results: Hamstring autografts had larger CSAs than native ACLs at all time points ( P < .001), with region of difference decreasing from proximal 95% of length (6 months) to proximal 77% of length (24 months). Restored ACLs had larger CSAs than native ACLs at 6 and 12 months, with larger than native CSA only along a small midsubstance region at 24 months ( P < .001). Graft CSA was correlated significantly with weight (6 and 12 months), bicondylar width (all time points), and notch width (24 months). Restored ACL CSA was significantly correlated with bicondylar width (6 months) and notch width (6 and 12 months). Conclusion: Surgically treated ACLs remodel continuously within the first 2 years after surgery, leading to ligaments/grafts with heterogeneous CSAs along the length, similar to the native ACL. While reconstructed ACLs remained significantly larger, the restored ACL had a CSA profile comparable with that of the contralateral native ACL. In addition to size and morphology differences, there were fundamental differences in factors contributing to CSA profile between the ACL reconstruction and BEAR procedures. Registration: NCT 02664545 ( ClinicalTrials.gov identifier).
Eptinezumab administered intravenously, subcutaneously, or intramuscularly in healthy subjects and/or patients with migraine: Early development studies
Authors: Baker Brian , Shen Vivienne , Cady Roger , Ettrup Anders , Larsen Frank 
Published: October 2022

Objective: To report the safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) of eptinezumab using intravenous (IV) infusion compared to other routes of administration from two phase 1 trials. Methods: Study 1 (NCT01579383) and Study 2 (ACTRN12615000531516) were double-blind, placebo-controlled, randomized trials. Study 1 singly administered ascending doses of eptinezumab 1–1000 mg IV infusion or 100 mg subcutaneous (SC) injection to healthy adults on day 1 ( n = 60); in a second part, eptinezumab 300 mg IV + sumatriptan 6 mg SC was administered to healthy adults and patients with migraine ( n = 18). Study 2 administered eptinezumab 100 or 300 mg intramuscular (IM), 100 mg SC, or 100 mg IV to healthy adults on days 1 and 84 ( n = 60). Results: No withdrawals due to treatment-emergent adverse events (TEAEs) were reported due to IV administration, with IV generally reporting TEAEs similar to placebo. The pharmacokinetics of eptinezumab were as expected for a monoclonal antibody, with the 100 mg and 300 mg IV doses exhibiting higher C max and shorter t max compared to identical SC and IM doses. Discussion: These phase 1 safety and tolerability data supported eptinezumab intravenous infusions at 100 and 300 mg; both were approved for migraine prevention, were well tolerated, had low immunogenicity and rapid attainment of high plasma concentrations.
Transcutaneous Approach to Treat a Fracture of the Anterior Wall of the Frontal Bone With Low Level of Comminution: A Case Report Closed Reduction of a Midfacial Bone Fracture
Authors: Abdalla Barbosa Brunno di Azevedo , Pastore Patrícia Radaic , Barreto Gustavo Lopes , Freitas Lilian Santos , Pastore Gabriel Pires 
Published: October 2022

Study design case report. Objective present a transcutaneous approach to treat a fracture of the anterior wall of the frontal bone with low level of comminution. Methods the fracture was studied in detail with computed tomography (CT) and the patient was treated with a closed reduction of a midfacial bone fracture with the use of transcutaneous screws. Results Optimal aesthetic result was achieved without any adverse event up. CT at 6-month follow-up demonstrated good bone alignment of the anterior wall of the fractured frontal sinus. Conclusion Closed approaches, when well indicated, can be an interesting treatment option for isolated fractures of the anterior wall of the frontal sinus with low levels of comminution.
Analysis of disparities in time to allogeneic transplantation in adults with acute myelogenous leukemia
Authors: Fingrut Warren B. , Gyurkocza Boglarka , Flynn Jessica , Davis Eric , Devlin Sean , Scaradavou Andromachi , Chinapen Stephanie , Quach Sean , Cho Christina , Giralt Sergio A. , Jakubowski Ann A. , Lin Richard J. , Papadopoulos Esperanza B. , Perales Miguel-Angel , Ponce Doris , Shaffer Brian C. , Tamari Roni , Young James W. , Politikos Ioannis , Barker Juliet N. 
Published: October 2022

Abstract
Although alternative donors extend transplant access, whether recipient ancestry affects the time to allogeneic transplant is not established. We analyzed the likelihood of clinically significant delays to allograft by patient ancestry in 313 adult patients with acute myelogenous leukemia (AML) who underwent transplantation. Non-European ancestry patients (n = 99) were more likely than Europeans (n = 214) to receive HLA-mismatched donor allografts (45% vs 24%). Overall, the median time from transplant indication to allograft was 127 days (range, 57-1683). In multivariable analysis, non-Europeans had an increased risk of prolonged indication to transplant time &gt;180 days owing to significant delays in indication to consult &gt;90 days and consult to transplant &gt;120 days. Compared with recipients of HLA-matched unrelated donors (URDs), HLA-mismatched adult donor recipients were at an increased risk of delayed indication to transplant, whereas HLA-identical sibling and cord blood recipients were at a lower risk. Subanalysis showed more indication to transplant delays &gt;180 days in non-European (44%) vs European (19%) 8/8 URD recipients. Finally, the pandemic further exacerbated delays for non-Europeans. In summary, although non-European patients with AML are less likely to receive 8/8 URDs as expected, if they do, their transplants are delayed. HLA-identical siblings and cord blood facilitate the fastest transplants regardless of patient ancestry, whereas other adult donor transplants are delayed. Strategies to mitigate referral barriers, hasten donor evaluation, and use all alternative donor sources are critical to ensure timely transplantation for patients with AML.
Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus
Authors: Rodriguez-Morales Roberto , Gonzalez-Lerma Paola , Yuiska Anders , Han Ji Heon , Guerra Yolanda , Crisostomo Lina , Keene Alex C. , Duboue Erik R. , Kowalko Johanna E. 
Published: October 2022

Abstract
Background
Aggression is observed across the animal kingdom, and benefits animals in a number of ways to increase fitness and promote survival. While aggressive behaviors vary widely across populations and can evolve as an adaptation to a particular environment, the complexity of aggressive behaviors presents a challenge to studying the evolution of aggression. The Mexican tetra, Astyanax mexicanus exists as an aggressive river-dwelling surface form and multiple populations of a blind cave form, some of which exhibit reduced aggression, providing the opportunity to investigate how evolution shapes aggressive behaviors.

Results
To define how aggressive behaviors evolve, we performed a high-resolution analysis of multiple social behaviors that occur during aggressive interactions in A. mexicanus. We found that many of the aggression-associated behaviors observed in surface-surface aggressive encounters were reduced or lost in Pachón cavefish. Interestingly, one behavior, circling, was observed more often in cavefish, suggesting evolution of a shift in the types of social behaviors exhibited by cavefish. Further, detailed analysis revealed substantive differences in aggression-related sub-behaviors in independently evolved cavefish populations, suggesting independent evolution of reduced aggression between cave populations. We found that many aggressive behaviors are still present when surface fish fight in the dark, suggesting that these reductions in aggression-associated and escape-associated behaviors in cavefish are likely independent of loss of vision in this species. Further, levels of aggression within populations were largely independent of type of opponent (cave vs. surface) or individual stress levels, measured through quantifying stress-like behaviors, suggesting these behaviors are hardwired and not reflective of population-specific changes in other cave-evolved traits.

Conclusion
These results reveal that loss of aggression in cavefish evolved through the loss of multiple aggression-associated behaviors and raise the possibility that independent genetic mechanisms underlie changes in each behavior within populations and across populations. Taken together, these findings reveal the complexity of evolution of social behaviors and establish A. mexicanus as a model for investigating the evolutionary and genetic basis of aggressive behavior.
Risk factors for portal hypertensive gastropathy
Authors: Wu Ran , Liu Kunyi , Shi Chengyi , Tian Hui , Wang Na 
Published: October 2022

Abstract
Background
Portal hypertensive gastropathy (PHG) is often underestimated in clinical diagnosis. Gastrointestinal bleeding in cirrhosis of PHG accounts for approximately 10% of upper gastrointestinal bleeding. However, the relationship between PHG and gender, laboratory parameters, liver function and varices is still controversial. In the present study, we aimed to retrospectively evaluate the incidence of PHG and to explore the relationship between PHG and gender, laboratory parameters, liver function and varicose veins.

Methods
A retrospective analysis of 325 patients with cirrhosis who underwent esophagogastroduodenoscopy (EGD) in the Department of Gastroenterology of the Second Hospital of Hebei Medical University from 1 January 2018 to 31 December 2020 was performed. The relationships among age, gender, laboratory parameters, Child–Pugh stage, oesophageal varices (EV), gastric varices (GV) and ascites with PHG were analysed with univariate and multivariate logistic regression.

Results
The occurrence of PHG was significantly associated with gender, haemoglobin, platelet count, prothrombin time, albumin, Child–Pugh stage, EV, GV and ascites (P < 0.05). Furthermore, there was a positive correlation between the severity of PHG and the degree of EV, GV and ascites (P < 0.05). Multivariate logistic regression showed that albumin, EV and GV levels were independently associated with the occurrence of PHG.

Conclusion
The incidence of PHG in cirrhosis was 87.4% in this study. The occurrence of PHG was related to gender, haemoglobin, platelet count, prothrombin time, albumin, Child–Pugh stage, EV, GV and ascites. Albumin, the degree of EV and GV are independent risk factors for the occurrence of PHG.
The 30-day hospital readmission and mortality after surgery in colorectal cancer patients
Authors: Alyabsi Mesnad S. , Alqarni Anwar H. , Almutairi Latifah M. , Algarni Mohammed A. , Alshammari Kanan M. , Almutairi Adel , Alselaim Nahar A. 
Published: October 2022

Abstract
Purpose
Hospital readmissions in the first weeks following surgery are common, expensive, and associated with increased mortality among colorectal cancer patients. This study is designed to assess the 30-day hospital readmission after colorectal cancer surgery and evaluate the risk factors that affect hospital readmission.

Methods
The study uses data from the Ministry of National Guard-Health Affairs Cancer Registry. All colorectal cancer patients who underwent colorectal cancer surgery between January 1, 2016, and November 31, 2021, were investigated. Factors examined were age, gender, marital status, Body Mass Index, Charlson Comorbidity Index, chemotherapy, radiotherapy, tumor stage, grade, site, surgical approach, length of stay, and discharge location. Kaplan–Meier curves were constructed to assess survival rates between readmitted and non-readmitted patients, and logistic regressions were performed to assess predictors of readmission.

Results
A total of 356 patients underwent tumor resection and 49 patients were readmitted within 30-day of index discharge. The most common reasons for hospital readmissions were gastrointestinal (22.45%), urinary tract infection (16.33%), and surgical site infection (12.24%). In the multivariable analysis, females were 89% more likely to be readmitted compared to males (odds ratio 1.89, 95% confidence intervals 1.00–3.58). Patients with distant metastatic tumors have higher odds of readmission (odds ratio 4.52, 95% confidence intervals 1.39–14.71) compared to patients with localized disease.

Conclusions
Colorectal cancer readmission is more common in patients with metastatic disease. Strategies to reduce readmission include planned transition to outpatient care, especially among patients with a high risk of readmission.
Home-based training technology for persons with dementia: a qualitative study of barriers and facilitators for mobility-based training at home
Authors: Ladekjær Larsen Eva , Waldorff Frans Boch , Hansen Helle Ploug , la Cour Karen 
Published: October 2022

Abstract
Background
Physical training is increasingly used in rehabilitation for older people with dementia and several studies have documented positive results. Currently, welfare nations promote motion-based technology (MBT) at home to replace group training in various rehabilitation interventions. Research on the use of MBT by people with dementia is sparse. Therefore, this study explores how people with mild dementia and their relatives experience home-based MBT training in an intervention facilitated by a Danish municipality.

Methods
The study is part of a feasibility study and builds on participant observation and interviews with people with dementia (n = 4), their relatives (n = 4), and health care workers (n = 3) engaged in the project.

Results
Participants compared MBT training to group training and found that MBT was not a satisfactory replacement for group training. Some participants used and enjoyed MBT daily while others were challenged by the technology, the placement of the device, or motivation to independently complete the training program.

Conclusion
MBT is possibly best considered as a supplement to group training, suitable for individuals able to use it in daily life.
Association between active cytomegalovirus infection and lung fibroproliferation in adult patients with acute respiratory distress syndrome: a retrospective study
Authors: Zhang Zhihui , Li Rujian , Chen Yubiao , Zhang Jierong , Zheng Yongxin , Xu Minmin , Liang Jiaqi , Li Jiahui , Huang Yongbo , Xu Yonghao , He Weiqun , Liu Xiaoqing , Li Yimin 
Published: October 2022

Abstract
Background
Cytomegalovirus (CMV) has high seroprevalence, and its active infection is associated with several adverse prognoses in adult patients with acute respiratory distress syndrome (ARDS). However, the role of active CMV infection in ARDS-associated fibroproliferation is unknown. This study aimed at determining the association between active CMV infection and lung fibroproliferation in adult patients with ARDS.

Methods
We retrospectively reviewed the medical records of all adult patients with ARDS who were admitted to the intensive care unit (ICU) from January 2018 to December 2020 at a national university-affiliated hospital in China. Study subjects were divided into active and non-active CMV infection groups based on CMV DNAemia within a 28-day ICU hospitalization. Lung fibroproliferation was measured using chest high-resolution computed tomography (HRCT) and N-terminal peptide of serum procollagen III (NT-PCP-III) within the first 28 days of ICU admission. Pulmonary fibrosis, clinical features, laboratory findings, treatment measures, and clinical outcomes were compared between the two groups.

Results
Among the 87 ARDS patients included in this study, the incidence of active CMV infection was 16.1% within the 28-day ICU admission period. In logistic regression analyze, active CMV infection was found to be associated with higher pulmonary fibrogenesis, pulmonary fibrosis score, and NT-PCP-III level (P < 0.05). The duration of ICU stay in ARDS patients with active CMV infection was significantly higher than in those without active CMV infection (P < 0.05).

Conclusions
Among adult patients with ARDS, active CMV infection was related to poor clinical outcomes. Active CMV infection was associated with ARDS-associated fibroproliferation. Prophylactic and preemptive use of anti-CMV agents on pulmonary fibrosis should be assessed to determine a consensus therapeutic strategy.