bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rechargeable Manganese Dioxide−Zinc Batteries: A Review Focusing on Challenges and Optimization Strategies under Alkaline and Mild Acidic Electrolyte Media
Authors: Debnath Subhrajyoti , Maiti Apurba , Naskar Pappu , Banerjee Anjan 
Published: July 2022

AbstractHerein, we have reviewed the recent developments of rechargeable manganese dioxide−zinc (MnO2−Zn) batteries under both alkaline and mild acidic electrolyte systems. The evolution pathway of MnO2−Zn system from Leclanché cell to alkaline primary batteries and from primary to secondary batteries is chronologically depicted. Several adverse phenomena are associated with the reversibility of metallic zinc negative electrode under alkaline (pH 14) electrolyte mediums, and these may include zinc dendrite formation, passivation of electrode surface, shape change of the electrode, zincate crossover through separator and hydrogen evolution upon charging. The MnO2positive electrode also experiences few performance degrading issues under alkaline mediums; like generation of electrochemically inert phases (Mn3O4and ZnMn2O4) in the electrode upon deep‐discharge and Mn‐dissolution in the electrolyte. The mitigation measures of these challenges are well documented and systematically analysed. On the invention of zinc‐ion batteries, the MnO2−Zn secondary batteries are assembled under mild acidic (pH 4–6) electrolytes, and eventually, several adverse effects of alkaline systems are drastically nullified. However, recent scientific and technical efforts are coined to address the challenges of large‐scale MnO2−Zn batteries in mild acidic mediums, and formulate the optimization strategies. This review culminates with a few smart designs of MnO2−Zn batteries, whereas, truly path‐breaking concepts are associated with. To the best of our knowledge, it is the first review that covers the entire spectrum of MnO2−Zn system in both alkaline and mild acidic mediums, along with evolution pathways.
Pharmacokinetics of Amoxicillin and Clavulanate Potassium for Suspension (200 mg/28.5 mg) in Healthy Subjects: Sample Add Stabilizer Study and Food Effects
Authors: Xu Su‐Mei , Qin Fei , Zhang Yong‐Dong , Xu Ping‐Sheng 
Published: July 2022

AbstractThe present study compares the pharmacokinetics of amoxicillin and clavulanate potassium suspension (200 mg/28.5 mg) during fasting and postprandial conditions, and the sample adds a stabilizer study. Two randomized, crossover trials were conducted in an open‐label, single‐center study (a fasting trial and a postprandial trial). In each part of the study, the subjects were randomly assigned to receive either test or reference products (200 mg/28.5 mg) in a 1:1:1 ratio, followed by the alternative products after a 7‐day washout period. Plasma amoxicillin and clavulanic acid concentrations were analyzed by liquid chromatography–tandem mass spectrometry. WinNonlin software was used to evaluate the pharmacokinetic parameters (noncompartmental model). The formulations were considered bioequivalent if the geometric means of area under the plasma concentration–time curve (AUC) and maximum plasma concentration (Cmax) of amoxicillin and clavulanic acid were within the predetermined bioequivalence range established by average bioequivalence (ABE) or reference‐scaled ABE. Tolerability was assessed throughout the study. The postprandial trial and the fasting study each had 12 volunteers. Under fasting and postprandial conditions, the 90%CI for the ratio of geometric means of amoxicillin of Cmax, AUC from time 0 to the last measurable concentration, and AUC from time 0 to infinity were within the ABE acceptance limits (80%‐125%); the geometric means of clavulanic acid of Cmax (critbound, –0.03; point estimate, 1.07) were within the reference‐scaled ABE acceptance limits, and the AUC from time 0 to the last measurable concentration and AUC from time 0 to infinity were within the ABE acceptance limits (80%–125%). Time to maximum concentration of amoxicillin was delayed 1.0 hour with high‐fat meals compared to fasting conditions. Meantime, high‐fat meals decreased the exposure of clavulanic acid by nearly 40%. No serious adverse events were found among the subjects. The bioequivalence of test and reference amoxicillin and clavulanate potassium for suspension was validated in this study under fasting and postprandial conditions.
Cytomorphological and immunohistochemical features of pancreatic ductal adenocarcinoma in serous fluids
Authors: Nie Xiao‐Yu , Wang Qian , Wang Shou‐Mei , Xu Yi , Pan Yun‐Cui , Zhang Xin , Hu Ai‐Yan , Zhang Shu‐Hui 
Published: July 2022

AbstractBackgroundPancreatic ductal adenocarcinoma (PDAC) represents the most common primary pancreatic malignancy. An understanding of the cytomorphologic features of conventional ductal adenocarcinoma and its variants is important to ensure accurate diagnoses.MethodsThe clinicopathological and cytological data of serous fluids in PDAC patients were obtained from the electronic medical records and pathology database. All samples were analyzed and reclassified according to the “The International System for Reporting Serous Fluid Cytopathology” guidelines. Cytomorphologic features were examined with SurePath automatically prepared slides and stained using the Pap method in malignant (MAL) effusion specimens from 21 patients with PDAC. Immunocytochemical staining was conducted on 12 cell blocks from MAL PDAC effusion.ResultsA total of 137 serous fluids specimens of PDACs were included, among which 61 (44.5%), 9 (6.6%), 13 (9.5%), 52 (38.0%), and 2 (1.5%) patients were classified into malignancy, suspicious for malignancy, atypia of undetermined significance, negative for malignancy and nondiagnostic groups, respectively. The key cytologic features for the conventional type of PDAC included cohesive clusters of ductal cells in glandular crowding and disorganized “drunken honeycomb” pattern or intercalated duct‐like structure with anisonucleosis, cytoplasmic vacuoles, and concomitant “Indian‐file” configuration. Undifferentiated carcinoma was comprised of enlarged, undifferentiated, pleomorphic MAL cells. Adenosquamous carcinoma could show glandular and/or squamous differentiation. Colloid carcinoma was composed of three‐dimensional cancer cell clusters floating in thick mucin.ConclusionCrowding and disorganized “drunken honeycomb” pattern or intercalated duct‐like structure with anisonucleosis, may represent an important clue for diagnosing PDAC in serous fluids. Immunocytochemical staining in combination with review of medical records and cytomorphological data can serve as useful adjuncts for distinguishing between PDAC and its variants.
Power augmentation of ducted wind turbines for urban structures: Experimental, numerical, and economic approaches
Authors: Ranjbar Mohammad H. , Mashouf Hirad , Gharali Kobra , Rafiei Behnam , Al‐Haq Armughan , Nathwani Jatin 
Published: July 2022

AbstractRecent development in using wind turbines for urban areas results in inserting turbines inside buildings. As buildings' walls may act as a duct for the turbine, this study focuses on a ducted wind turbine with a fixed duct geometry. A method is organized for achieving the improved generated power and the wind speed augmentation with fixed geometry of duct regardless of the type of the turbine, which is the aim of building designers. Using a porous disc (PD) instead of a wind turbine rotor makes the study cost and time effective. PDs within a duct help estimate any given duct's maximum available power extraction capability. In addition, experimental and numerical tests examine the effect of PDs solidity on the performance of diffuser augmented wind turbines and the corresponding economic analysis. Both experimental and numerical results agree that the power coefficient highly depends on the solidities of the PD. The power coefficient of a ducted PD with a solidity of 0.3 is augmented by up to 30%. Nevertheless, in some cases, employing a duct can contribute to the power reduction if the solidity exceeds a critical value. A smoke visualization technique helps vortex study. Economic assessment of a ducted turbine for three scenarios belonging to Germany and Italy shows a 15.3% decline in cost per electricity production. The payback period decreases by 3.42 years, 7.68 months, and 6.36 months for Scenarios 1, 2, and 3.
Balancing Ecosystems, Harvests, and Seafood Markets
Authors: Collie Jeremy , Schumann Sarah , Masury Kate , Uchida Hirotsugu , Collie Claire 
Published: July 2022

Abstract
Recognition of competition and predator–prey interactions among species has led some to promote the concept of balanced harvesting, whereby fisheries would remove a proportional, sustainable fraction of all species in the fish community. Practical implementation of such a strategy hinges on understanding the current degree of species selection in fisheries and the factors that drive this selection. This interdisciplinary study measured ecosystem–market symmetry in the New England region by tracking species composition from ecosystem production, to catch, landings, and seafood markets. Strong species selection occurred in the catch and in seafood markets but not by discarding, which suggests that that requiring full retention of all species caught may make a limited contribution to promoting ecosystem–market symmetry. Results from a group of citizen scientists indicate that higher priced species were generally more available in seafood markets and that availability diminished rapidly with distance from shore. We conclude that market-based selection may be reduced through a combination of locavore consumer education and global marketing strategies.
Potential eligibility for Aducanumab therapy in an Irish specialist cognitive service—Utilising cerebrospinal fluid biomarkers and appropriate use criteria
Authors: Togher Zara , Dolphin Helena , Russell Caoimh , Ryan Marie , Kennelly Séan P. , O'Dowd Séan 
Published: July 2022

AbstractObjectivesAducanumab is a monoclonal antibody which has recently been licenced for use by the food and drug administration for treatment of patients with mild cognitive impairment due to Alzheimer's disease (AD) or mild AD dementia. Appropriate use criteria (AUC) for Aducanumab in clinical practice are available. We look to review patients in our specialist interdisciplinary cognitive service with positive cerebrospinal fluid (CSF) biomarkers for AD for their hypothetical eligibility for Aducanumab, or a similar anti‐amyloid agent.MethodsRetrospective analysis was undertaken of patients with positive AD‐biomarker CSF analysis. Data available at time of CSF analysis was reviewed to determine hypothetical eligibility for Aducanumab.ResultsSeventy patients had positive AD‐CSF biomarkers. Forty nine of these were seen in the Gerontology‐led service, with 21 in the neurology cohort. Average patient age was 70 years old. Forty patients (57%) met eligibility criteria for Aducanumab therapy by AUC guidelines.ConclusionWe highlight the patients within our service who would be appropriate for Aducanumab or similar anti‐amyloid agents should licencing be granted in the European Union, and the need to develop the resources and capacity to deliver this or other emerging disease modifying AD therapies.Clinical Trial Registration: All patients in the combined cognitive clinic provide consent re willingness to be contacted re research.
Large‐scale screening for factor V Leiden (G1691A), prothrombin (G20210A), and MTHFR (C677T) mutations in Greek population
Authors: Raptopoulou Alkistis , Michou Vassiliki , Mourtzi Niki , Papageorgiou Efstathia G. , Voyiatzaki Chrysa , Tsilivakos Vassilis , Beloukas Apostolos , Bei Thaleia A. 
Published: July 2022

AbstractBackground and aimsTo provide a fair estimate of the prevalence of factor V Leiden (FVL) (G1691A), prothrombin (G20210A), and MTHFR (C677T) mutations in the Greek population.MethodsWe genotyped a representative sample of 974 apparently healthy Greek adults by the method of real‐time PCR and we calculated the allele frequencies of factor V Leiden (FVL) (G1691A), prothrombin (G20210A), and MTHFR (C677T) mutations. In addition, we determined the frequency of co‐occurrence of FVL (1691A) and prothrombin (20210A), FVL (1691A) and MTHFR (677T), prothrombin (20210A) and MTHFR (677T) mutations.ResultsΤhe career frequencies of FVL (1691A), prothrombin (20210A), and MTHFR (677T) alleles were 7.5%, 4.5%, and 49.3% while the allele frequencies were 4%, 2.25%, and 39.5%, respectively. The coexistence of the allele frequencies combinations of two, FVL (1691A) and Prothrombin (20210A), FVL (1691A) and MTHFR (677T), prothrombin (20210A) and MTHFR (677T) was found in 1 (0.9%), 29 (3.5%), and 22 (3%) samples, respectively. Triple heterozygous carriers were not found.ConclusionAllele frequencies of the two (FVL and MTHFR) mutations are higher compared with published data. The large sample size of our study enhances the validity of our results and suggests a biological affinity of Greek population with Southern Italian populations.
Corruption and foreign bank entry denials: A cross‐country panel analysis
Authors: Lskavyan Vahe 
Published: July 2022

AbstractThe existing literature largely reports a negative effect of corruption on foreign direct investment (FDI) and explains it by the unwillingness of foreign investors to invest due to the high post‐entry costs and risks of corruption. However, in addition to affecting foreign investors' willingness to invest, corruption can also affect their ability to invest. This latter channel is less explored. To fill this gap, we use cross‐country panel data to analyse the relationship between corruption and foreign bank entry denials. Our fixed‐effects estimation results, as well as the following sensitivity checks show that corruption can also be an entry‐point deterrent: corrupt host countries are more likely to deny entry to foreign banks. This finding suggests that at least some foreign investors are forced rather than choose to stay out of corrupt countries. A policy implication could be that reducing the entry‐point corruption can increase foreign investment even if the post‐entry costs and risks of corruption remain unchanged.
Subsidy and product diversity in the presence of buyer power
Authors: Chen Zhiqi , Ding Hong 
Published: July 2022

AbstractThis paper analyzes the effectiveness of government subsidies in promoting product diversity when a downstream firm has buyer power. Using an extension of the Dixit‐Stiglitz model of monopolistic competition, we compare the effects of subsidies on the equilibrium number of differentiated products and social welfare in the case where products are sold directly to consumers versus the case where they are distributed through a monopoly retailer with buyer power. We find that a production subsidy promotes product diversity in both cases, but the mechanisms through which a subsidy raises the number of products are different. Compared with the case where products are distributed directly to consumers, retailer buyer power reduces product diversity and social welfare. Furthermore, it weakens the effectiveness of the subsidy in promoting product diversity. At any given subsidy rate the equilibrium number of products is smaller, and a rise in the subsidy rate leads to a smaller increase in the number of products.
The Uses of Engineering Notebooks Among Pre‐Engineering Students at a Hispanic‐Serving Institution
Authors: Mein Erika , Convertino Christina 
Published: July 2022

AbstractIn this article, we draw on sociocultural perspectives on literacy to explore the ways in which pre‐engineering students took up and made sense of engineering notebooks implemented as part of a robotics project in a first‐semester university study course at a large, public Hispanic‐Serving Institution. Through ethnographic methods, we uncovered two primary sets of uses for the notebooks: (1) recording and remembering and (2) problem solving and decision‐making. The study illustrates the ways in which entering college students, especially those from underrepresented groups who seek to become engineers, may take up opportunities to “try out” disciplinary literacies through meaningful engagement with the practices of the discipline.
Exposure to boron trioxide nanoparticles and ions cause oxidative stress, DNA damage, and phenotypic alterations in Drosophila melanogaster as an in vivo model
Authors: Turna Demir Fatma , Demir Eşref 
Published: July 2022

AbstractBoron trioxide nanoparticles (B2O3 NPs) have recently been widely used in a range of applications including electronic device technologies, acousto‐optic apparatus fields, and as nanopowder for the production of special glasses. We propose Drosophila melanogaster as a useful in vivo model system to study the genotoxic risks associated with NP exposure. In this study, we have conducted a genotoxic evaluation of B2O3 NPs (size average 55.52 ± 1.41 nm) and its ionic form in D. melanogaster. B2O3 NPs were supplied to third instar larvae at concentrations ranging from 0.1–10 mM. Toxicity, intracellular oxidative stress (reactive oxygen species, ROS), phenotypic alterations, genotoxic effect (via the wing somatic mutation and recombination test, SMART), and DNA damage (via Comet assay) were the end‐points evaluated. B2O3 NPs did not cause any mutagenic/recombinogenic effects in all tested non‐toxic concentrations in Drosophila SMART. Negative data were also obtained with the ionic form. Exposure to B2O3 NPs and its ionic form (at two highest concentrations, 2.5 and 5 mM) was found to induce DNA damage in Comet assay. Additionally, ROS induction in hemocytes and phenotypic alterations were determined in the mouths and legs of Drosophila. This study is the first study reporting genotoxicity data in the somatic cells of Drosophila larvae, emphasizing the importance of D. melanogaster as a model organism in investigating the different biological effects in a concentration‐dependent manner caused by B2O3 NPs and its ionic form. The obtained in vivo results contribute to improvement the genotoxicity database on the B2O3 NPs.
A case of severe DRESS syndrome treated with therapeutic plasma exchange and intravenous immunoglobulin therapy
Authors: Durak Cansu , Aydemir Sezin , Varol Fatih , Aygün Fatih , Çokuğraş Haluk Cezmi 
Published: July 2022

AbstractDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in children is a rare adverse drug reaction with skin rash, fever, hematologic abnormalities, and multiorgan involvement. The diagnosis is difficult because of its various clinical presentations, nonetheless is extremely important due to the mortality rate. We describe a 14‐year‐old boy who developed hypersensitivity to either teicoplanin or meropenem therapy. After failing to improve with corticosteroids, he was successfully treated with therapeutic plasma exchange (TPE). TPE should be considered in the treatment with corticosteroid‐resistant DRESS syndrome.
Research progress on serological indices and their clinical application in rheumatoid arthritis
Authors: Meng Shuting , Jing Longxiao , Zhang Weiwei , Wang Feng , Dong Yefeng , Dong Deping 
Published: July 2022

AbstractBackgroundAs a chronic systemic autoimmune disease of undetermined etiology, rheumatoid arthritis (RA) has a complex pathogenesis, which involves multiple proteins and cytokines. The 2010 ACR/EULAR classification criteria facilitate early diagnosis of RA with reduced specificity when compared to the 1987 ACR criteria. Hence, it is imperative to identify novel serological inflammatory indicators and targets, in order to explain the complex regulatory network of RA. The present review discusses the associations of various inflammatory factors with RA and its underlying mechanism. Besides, the review also provides a novel insight into the clinical treatment of RA.Materials and MethodsAccording to the PRISMA guidelines, databases like Web of Science, Google‐Scholar, Pubmed and Scopus were systematically searched for articles from January 1, 2018 to January 1, 2022 using The following 2 keywords: "rheumatoid arthritis", "Inflammatory cytokines", "ILs", "serum amyloid protein A", "matrix metalloproteinase 3", "RANKL", "Glucose‐6‐phosphoisomerase", "Anti‐keratin antibody", "1,25‐Dihydroxyvitamin D3".ResultsIndicators like MMPs, ILs, glucose‐6‐phosphate isomerase (GPI), anti‐keratin antibody (AKA) and receptor activator of nuclear factor‐κB ligand (RANKL) are the current hotspots in the efficacy research of RA. The present review suggests that ILs are highly expressed in the serum and synovial tissues of RA patients. By targeted inhibition of ILs with inhibitor application, precise RA treatment can be achieved.ConclusionsBased on these results, it can be concluded that inflammatory factors have certain guiding significance in the diagnosis and efficacy evaluation of RA. However, the mechanisms of interactions among them are rather complex, which deserve further exploration.
The intercorrelation among CCT6A, CDC20, CCNB1, and PLK1 expressions and their clinical value in papillary thyroid carcinoma prognostication
Authors: Peng Wei , Li Wenqiang , Zhang Xiaoyong , Cen Weili , Liu Yanan 
Published: July 2022

AbstractBackgroundCCT6A promotes several carcinomas' growth and invasion in multiple ways, and it relates to CCNB1 and PLK1 through its interaction with CDC20 via protein–protein interaction bioinformatics. This study aimed to explore the intercorrelation among CCT6A, CDC20, CCNB1, and PLK1, and their association with tumor features and prognosis in papillary thyroid carcinoma (PTC) patients.MethodsCCT6A, CDC20, CCNB1, and PLK1 expressions in 186 tumor and 30 non‐tumor specimens from PTC patients were determined by immunohistochemical (IHC). Clinical features, disease‐free survival (DFS), and overall survival (OS) were retrieved.ResultsCCT6A, CDC20, CCNB1, and PLK1 expressions were upregulated in tumor tissues compared with non‐tumor tissues (all p < 0.001). CCT6A expression positively correlated with CDC20, CCNB1, and PLK1 expressions; besides, CDC20 expression positively associated with CCNB1 and PLK1 expressions, and CCNB1 expression was also positively related to PLK1 expression (all p < 0.05). Moreover, elevated tumor CCT6A expression was correlated with extrathyroidal invasion (p = 0.015), higher pT stage (p < 0.001), pN stage (p = 0.046), and pTNM stage (p = 0.042); while tumor CDC20, CCNB1, and PLK1 expressions only correlated with some of these indexes (most p < 0.05). Notably, CCT6A and CDC20 high expressions predicted worse DFS and OS (all p < 0.05); CCNB1 positive expression only predicted poor DFS (p = 0.044) but not OS (p = 0.152); however, PLK1 expression failed to predict these two indexes (both p > 0.05). After adjustment using multivariate Cox's regression, CCT6A expression (high vs. low) independently estimated shorter DFS (p = 0.010) and OS (p = 0.006).ConclusionCCT6A, CDC20, CCNB1, and PLK1 are intercorrelated, and they exhibit certain prognostic values in PTC patients.