bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRAF3 alterations are frequent in del‐3′IGH chronic lymphocytic leukemia patients and define a specific subgroup with adverse clinical features
Authors: Pérez‐Carretero Claudia , Hernández‐Sánchez María , González Teresa , Quijada‐Álamo Miguel , Martín‐Izquierdo Marta , Santos‐Mínguez Sandra , Miguel‐García Cristina , Vidal María‐Jesús , García‐De‐Coca Alfonso , Galende Josefina , Pardal Emilia , Aguilar Carlos , Vargas‐Pabón Manuel , Dávila Julio , Gascón‐Y‐Marín Isabel , Hernández‐Rivas José‐Ángel , Benito Rocío , Hernández‐Rivas Jesús‐María , Rodríguez‐Vicente Ana‐Eugenia 
Published: April 2022

AbstractInterstitial 14q32 deletions involving IGH gene are infrequent events in chronic lymphocytic leukemia (CLL), affecting less than 5% of patients. To date, little is known about their clinical impact and molecular underpinnings, and its mutational landscape is currently unknown. In this work, a total of 871 CLLs were tested for the IGH break‐apart probe, and 54 (6.2%) had a 300 kb deletion of 3′IGH (del‐3′IGH CLLs), which contributed to a shorter time to first treatment (TFT). The mutational analysis by next‐generation sequencing of 317 untreated CLLs (54 del‐3′IGH and 263 as the control group) showed high mutational frequencies of NOTCH1 (30%), ATM (20%), genes involved in the RAS signaling pathway (BRAF, KRAS, NRAS, and MAP2K1) (15%), and TRAF3 (13%) within del‐3′IGH CLLs. Notably, the incidence of TRAF3 mutations was significantly higher in del‐3′IGH CLLs than in the control group (p < .001). Copy number analysis also revealed that TRAF3 loss was highly enriched in CLLs with 14q deletion (p < .001), indicating a complete biallelic inactivation of this gene through deletion and mutation. Interestingly, the presence of mutations in the aforementioned genes negatively refined the prognosis of del‐3′IGH CLLs in terms of overall survival (NOTCH1, ATM, and RAS signaling pathway genes) and TFT (TRAF3). Furthermore, TRAF3 biallelic inactivation constituted an independent risk factor for TFT in the entire CLL cohort. Altogether, our work demonstrates the distinct genetic landscape of del‐3′IGH CLL with multiple molecular pathways affected, characterized by a TRAF3 biallelic inactivation that contributes to a marked poor outcome in this subgroup of patients.
EBV‐positive diffuse large B‐cell lymphoma, not otherwise specified: 2022 update on diagnosis, risk‐stratification, and management
Authors: Malpica Luis , Marques‐Piubelli Mario L. , Beltran Brady E. , Chavez Julio C. , Miranda Roberto N. , Castillo Jorge J. 
Published: April 2022

AbstractDisease OverviewEpstein Barr virus‐positive (EBV+) diffuse large B‐cell lymphoma (DLBCL), not otherwise specified (NOS) is an entity included in the WHO classification of lymphoid neoplasms since 2016. EBV+ DLBCL, NOS, is an aggressive B‐cell lymphoma associated with EBV infection, and a poor prognosis with standard chemotherapeutic approaches.DiagnosisThe diagnosis is made through a careful pathological evaluation. Detection of EBV‐encoded RNA (EBER) is considered standard for diagnosis; however, a clear cutoff for percentage of positive cells has not been defined. The differential diagnosis includes plasmablastic lymphoma (PBL), DLBCL associated with chronic inflammation, primary effusion lymphoma (PEL), among others.Risk‐StratificationThe International Prognostic Index (IPI) and the Oyama score can be used for risk‐stratification. The Oyama score includes age >70 years and presence of B symptoms. The expression of CD30 and PD‐1/PD‐L1 are emerging as potential adverse but targetable biomarkers.ManagementPatients with EBV+ DLBCL, NOS, should be staged and managed following similar guidelines than patients with EBV‐negative DLBCL. EBV+ DLBCL, NOS, however, might have a worse prognosis than EBV‐negative DLBCL in the era of chemoimmunotherapy. Therefore, the inclusion of patients in clinical trials when available is recommended. There is an opportunity to study and develop targeted therapy in the management of patients with EBV+ DLBCL, NOS.
Proton pump inhibition for secondary hemochromatosis in hereditary anemia: a phase III placebo‐controlled randomized cross‐over clinical trial
Authors: van Vuren Annelies , Kerkhoffs Jean Louis , Schols Saskia , Rijneveld Anita , Nur Erfan , Peereboom Dore , Gandon Yves , Welsing Paco , van Wijk Richard , Schutgens Roger , van Solinge Wouter , Marx Joannes , Leiner Tim , Biemond Bart , van Beers Eduard 
Published: April 2022

AbstractIron overload is a severe general complication of hereditary anemias. Treatment with iron chelators is hampered by important side‐effects, high costs, and the lack of availability in many countries with a high prevalence of hereditary anemias. In this phase III randomized placebo‐controlled trial, we assigned adults with non‐transfusion‐dependent hereditary anemias with mild‐to‐moderate iron overload to receive esomeprazole (at a dose of 40 mg twice daily) or placebo for 12 months in a cross‐over design. The primary end point was change of liver iron content measured by MRI. A total of 30 participants were enrolled in the trial. Treatment with esomeprazole resulted in a statistically significant reduction in liver iron content that was 0.55 mg Fe/g dw larger than after treatment with placebo (95%CI [0.05 to 1.06]; p = 0.03). Median baseline liver iron content at the start of esomeprazole was 4.99 versus 4.49 mg Fe/g dw at start of placebo. Mean delta liver iron content after esomeprazole treatment was −0.57 (SD 1.20) versus −0.11 mg Fe/g dw (SD 0.75) after placebo treatment. Esomeprazole was well tolerated, reported adverse events were mild and none of the patients withdrew from the study due to side effects. In summary, esomeprazole resulted in a significant reduction in liver iron content when compared to placebo in a heterogeneous group of patients with non‐transfusion‐dependent hereditary anemias. From an international perspective this result can have major implications given the fact that proton pump inhibitors may frequently be the only realistic therapy for many patients without access to or not tolerating iron chelators.
Ternary Alloy PtWMn as a Mn Nanoreservoir for High‐Field MRI Monitoring and Highly Selective Ferroptosis Therapy
Authors: Guan Guoqiang , Zhang Cheng , Liu Huiyi , Wang Youjuan , Dong Zhe , Lu Chang , Nan Bin , Yue Renye , Yin Xia , Zhang Xiao‐Bing , Song Guosheng 
Published: April 2022

AbstractFerroptosis exhibits potential to damage drug‐resistant cancer cells. However, it is still restricted with the “off‐target” toxicity from the undesirable leakage of metal ions from ferroptosis agents, and the lack of reliable imaging for monitoring the ferroptosis process in living systems. Herein, we develop a novel ternary alloy PtWMn nanocube as a Mn reservoir, and further design a microenvironment‐triggered nanoplatform that can accurately release Mn ions within the tumor to increase reactive oxygen species (ROS) generation, produce O2and consume excess glutathione for synergistically enhancing nonferrous ferroptosis. Moreover, this nanoplatform exerts a responsive signal in high‐field magnetic resonance imaging (MRI), which enables the real‐time report of Mn release and the monitoring of ferroptosis initiation through the signal changes of T1‐/T2‐MRI. Thus, our nanoplatform provides a novel strategy to store, deliver and precisely release Mn ions for MRI‐guided high‐specificity ferroptosis therapy.
Electrochemical performance of yttria‐doped SrCoO3‐δas cathode material for anode‐supported solid oxide fuel cell
Authors: Wang Yujia , Cheng Lingyan , Zhang Qi , Huang Qi , Sarker M. D. Abdul Hamid , Jiang Shanshan , Su Chao 
Published: April 2022

AbstractYttria‐doping strategies of strontium cobaltite (SrCoO3‐δ) have been systematically investigated as high‐performance cathode materials for anode‐supported solid oxide fuel cells. Sr0.95Y0.05CoO3‐δ(SYC), SrCo0.95Y0.05O3‐δ(SCY), and Sr0.95Y0.05Co0.95Y0.05O3‐δ(SYCY) were prepared by the citrate complexation sol–gel method. The crystal structures, oxygen desorption characterizations, electronic conductivities, and electrochemical performances were studied. The research result suggested that yttria doping into the A‐site of SrCoO3‐δ(SYC) exhibited the highest electronic conductivity (~580 S cm−1), and the suppression of the oxygen vacancies results in the poor performance of oxygen reduction reaction (ORR) activity. The yttria doping into the B‐site of SrCoO3‐δ(SCY) inhibits the oxygen desorption related to the Co3+to Co2+and electronic conductivity. The co‐doping yttria of SrCoO3‐δ(SYCY) shows the lowest area‐specific resistances (0.147 Ω cm2at 600°C) and lowest activation energy (103.8 KJ mol−1). The ORR processes of SYC, SCY, and SYCY electrodes were analyzed by the distribution of relaxation time (DRT) technique. The I‐V and I‐P performances of SYCY cathode based on the anode‐supported single fuel cell were also being exploited, and the peak power density of this cell is 1005 mW cm−2at 650°C. The encouraging results suggest that SYCY is a candidate reduction electrode for solid oxide fuel cell.
XPS, UV–Vis, XRD, and PL spectroscopies for studying nickel nanoparticle positioning effect on nanocomposite film properties
Authors: Jum'h Inshad , Telfah Ahmad , Mousa Marwan S. , Ahmad Mais Jamil A. , Tavares Carlos J. , Hergenröder Roland 
Published: April 2022

AbstractThis work studies the impact of positioning nickel nanoparticles (Ni‐NPs) on the surface of doped (P84‐PEO) nanocomposite films by using an ultra‐uniform magnetic field as a model for positioning magnetic NPs inside a polymeric matrix. This process is used to achieve desired and adjustable optoelectronic properties and to obtain new optical and electrical characteristics. P84‐PEO copolymer doped with Ni‐NPs exposed to a 450 mT magnetic field during the preparation give rise to a momentous increase in surface roughness, surface reactivity, and modified optical parameters, besides forming Ni oxides on the surface. Based on X‐ray photoelectron spectroscopy experiments, substantial extra shifts occurred in the binding energies of photo‐excited electrons from the O1s and C1s core levels. Additionally, the deconvoluted O1s spectra displays an additional photoelectron peak at 530.0 eV, most likely attributed to oxidized Ni‐NPs at the surface. Moreover, optical and structural properties were studied using UV–Vis and PL spectroscopy and X‐ray diffraction.
Effect of hybrid carbon nanofillers at percolation on electrical and mechanical properties of glass fiber reinforced epoxy
Authors: Bilugali Mahadevaswamy Madhu , Aradhya Rashmi , Bhattacharya Sailaja , Jagannathan Sundara Rajan 
Published: April 2022

AbstractMulti walled carbon nanotubes and graphene nanoplatelets are novel fillers possessing exceptional intrinsic characteristics, such as high aspect ratio, strength, and good compatibility. These fillers are integrated into a glass fiber reinforced epoxy using a pultrusion process with a mixing ratio of 2:3 to attain the synergetic effect. The electrical and mechanical properties of the composites containing combinations of multi walled carbon nanotubes (0.4 wt%), graphene nanoplatelets (0.6 wt%) and micron aluminum trihydrate (2 wt%) fillers is studied. Significant improvement in electrical and mechanical properties is achieved. This study reveals that the incorporation of hybrid carbon nanofillers into epoxy leads to improved dielectric constant, AC conductivity and mechanical properties as compared with the base epoxy composite with glass reinforcement. The AC conductivity increases from 10−9 to 10−1 S/m and dielectric constant from 3.6 to 100 due to carbon fillers. The mean tensile strength improves from 433 MPa of the base epoxy composite to 508 MPa in carbon‐filled composite. The compressive strength improves from 630 to 681 MPa due to incorporation of carbon fillers signifying the improvement in load transfer effectiveness. The effect of carbon fillers on the flexural strength and hardness is minimal. The experimental data on mechanical parameters have been validated using theoretical modeling and a good correlation is established.
Nanofibrous composite from polycaprolactone‐polyethylene glycol‐aloe vera as a promising scaffold for bone repairing
Authors: Dehghan Fatemeh , Gholipour‐Kanani Adeleh , Kamali Dolatabadi Mehdi , Bahrami Seyed Hajir 
Published: April 2022

AbstractRecently, herbal extract‐loaded nanofibers have been developed using different types of components for tissue engineering applications. In this study, nanofibrous webs are fabricated from polycaprolactone (PCL)‐polyethylene glycol (PEG) 1:1 mass ratio blend incorporated with different amounts of aloe vera extract through electrospinning. Combining the potential therapeutic properties of aloe vera in bone repair with physicochemical and biological properties of the nanofibers leads to design a promising scaffold for bone repairing. The produced scaffolds are characterized using scanning electron microscopy, Fourier transform infrared (FTIR), and mechanical‐strength test. From the results, the electrospun PCL‐PEG‐aloe vera web with 1:1:1 mass ratio shows a bead‐less bimodal morphology consisting of nano‐scale and micro‐scale fibers with an average diameter of 280 and 670 nm, respectively. FTIR spectra revealed the possible hydrogen bonding between the three components. Mechanical investigation exhibited higher strength of aloe vera loaded nanofibers to unloaded nanofibers. From the MTT assay results, aloe vera‐loaded nanofibrous scaffolds showed a high level of cell compatibility as well as excellent penetration, cell growth, and proliferation. According to the result of calcination, the ability of bone repairing was verified. The result confirmed a higher amount of calcium deposition on nanofibrous scaffolds incorporated with aloe vera extract.
Cascade active disturbance rejection control of single‐rod electrohydrostatic actuator
Authors: Han Xiaoxia , Chen Zhixiang , Feng Yongbao , Xie Jian , Wei Xiaoling , Wei Liejiang 
Published: April 2022

AbstractElectrohydrostatic actuators (EHAs) are used to replace traditional centralized hydraulic systems to reduce weight and improve efficiency and maintainability. This paper proposes a cascade active disturbance rejection control (C‐ADRC) method for single‐rod EHAs with parametric uncertainties and severe external disturbances. The studied EHA can be transformed into a cascade connection of a first‐order pressure system and a second‐order position system. Two linear active disturbance rejection controllers are designed for the inner pressure system and the outer position system to estimate and compensate for various uncertainties in the two loops, respectively. The uniqueness of the C‐ADRC is that the two linear active disturbance rejection controllers are designed by making full use of the measurable states and known model information of the EHA system. It is theoretically proved that the closed‐loop system is semi‐globally uniformly ultimately bounded. Moreover, the proposed controller can theoretically ensure position tracking with desired accuracy as the bandwidth of extended state observers (ESOs) becomes sufficiently high. Simulation and experimental results verify the effectiveness of the proposed method.
Using vocal consequences with TAGteach™ to teach novel dance movements to adults
Authors: Arnall Robin , Griffith Annette K. , Kalafut Kathryn , Spear Jack 
Published: April 2022

AbstractResearchers have demonstrated the effectiveness of TAGteach™ to develop skills across a variety of sports, such as football, golf, and dance, however, the role of vocal consequences in skill development is not yet fully understood. To date, there have been no studies that have examined the effects of these two interventions. Therefore, the purpose of this study is to demonstrate the effects of vocal consequences and TAGteach on the skill acquisition of a series of dance movements for two adults aged 28 and 43. Neither participant made substantial gains in skill acquisition during the vocal consequences (e.g., “great,” “not quite”) phase, yet each demonstrated increased skill acquisition for all movements during the TAGteach phase. Although no direct comparison occurred, the data suggest that the TAGteach intervention was more effective for increasing skill acquisition of the movements across a multiple baseline of movements. At the 2‐week and 4‐week follow‐ups, both participants maintained higher percentages of correct tag point demonstration than were displayed during baseline or the vocal consequence phase.
Variations in human pulmonary vein ostia morphology: A systematic review with meta‐analysis
Authors: Bonczar Michał , Piątek‐Koziej Katarzyna , Wolska Joanna , Tomala Olaf , Stitou El‐Ayachi , Pękala Jakub , Pękala Przemysław , Walocha Jerzy , Hołda Mateusz , Koziej Mateusz 
Published: April 2022

AbstractThis study aimed to establish the most accurate and up‐to‐date anatomical knowledge of pulmonary veins (PV), ostia variations, diameters and ostial area, to provide physicians, especially heart and thoracic surgeons with exact knowledge concerning this area. The main online medical databases, such as PubMed, Embase, Scopus, Web of Science, and Google Scholar, were searched to gather all studies in which the variations, maximal diameter, and ostial area of the PVs were investigated. During the study, the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) guidelines were followed. Additionally, the critical appraisal tool for anatomical meta‐analysis (CATAM) was used to provide the highest quality findings. The most common ostia variation is the classical one, which contains the left superior pulmonary vein (LSPV), left inferior pulmonary vein (LIPV), right superior pulmonary vein (RSPV) and right inferior pulmonary vein (RIPV). The mean diameter and ostial area of each pulmonary vein were established in the general population and in multiple variations considering the method of collecting the data and geographical location. Significant variability in PV ostia is observed. Left‐sided PVs have smaller ostia than the corresponding right‐sided PVs, and the inferior PVs ostia are smaller than the superior. The LCPV ostium size is the largest among all veins analyzed, while the RMPV ostium is the smallest. The results of this meta‐analysis are hoped to help clinicians in planning and performing procedures that involve the pulmonary and cardiac areas, especially catheter ablation for atrial fibrillation.
Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking
Authors: Koca Mehmet , Güller Uğur , Güller Pınar , Dağalan Ziya , Nişancı Bilal 
Published: April 2022

AbstractThe major cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), are important in the therapy of Alzheimer's disease (AD) based on the cholinergic hypothesis. As a result, in recent years, the investigation of dual cholinesterase inhibition methods has become important among scientists. In this study, novel N‐(4‐chlorobenzyl)‐3,4‐dimethoxy‐N‐(m‐substituted)benzamide derivatives were synthesized. Then, inhibitory properties of these derivatives were examined in human AChE and BuChE in vitro and possible interactions were determined by molecular docking studies. All benzamide derivatives were exhibited dual inhibitory character and high BBB permeability. The most effective inhibitor was found as N7 for both AChE and BuChE with IC50 values of 1.57 and 2.85 μM, respectively. Besides the most potent inhibitor was predicted as N7 in terms of binding energies with −12.18 kcal/mol and −9.92 kcal/mol, respectively. The reason for these results is that bromine (N7) is the bulkiest molecule among the other substituted groups. These derivatives could be exploited to develop new medications for the treatment of central nervous system‐related diseases as AD by acting as dual inhibitors of AChE and BChE.
Discoid lupus erythematosus of the palms: A case report
Authors: Zhou Albert E. , Shaikh Gibran , Driscoll Marcia S. 
Published: April 2022

AbstractDiscoid lupus erythematosus is an autoimmune connective‐tissue disease that represents a subset of conditions on the cutaneous lupus spectrum. The lesions are characterized by disk‐shaped plaques on photo‐exposed skin with inflammatory hyperpigmentation and adherent scale. Here, we present a patient with a rare manifestation of discoid lesions on the palms.
Catheter‐directed thrombolysis for massive deep vein thrombosis in an adolescent with severe antithrombin deficiency
Authors: Bønløkke Søren Thorgaard , Serifi Maria Arvad , Mikkelsen Torben Stamm , Hvas Anne‐Mette 
Published: April 2022

AbstractIn this case report we describe a case of massive deep vein thrombosis in an adolescent. The case was complicated by severe antithrombin deficiency caused by a previously unreported mutation. We discuss the use of catheter directed thrombolysis and (F)Xa inhibitors in children and adolescents.
The specification of color limits in eye protection lenses for use when color‐contingent clinical observations are made
Authors: Dain Stephen J. , Hovis Jeffery K. , Hoskin Annette K. 
Published: April 2022

AbstractObjectiveTo investigate if color limitations in eye and face protection standards are sufficient to avoid interfering significantly in color‐contingent clinical decisions. If not, to propose what requirement will ensure appropriate products.MethodsYellow‐tinted eye protectors, blue‐blocking lenses and lightly tinted filters were assessed for compliance with eye and face protection standards and their effect on the color rendering.ResultsYellow‐tinted eye protectors and many tinted filters cause significant noncompliance with hospital lighting recommendations and standards; however general eye protection standards do not exclude these lenses. The standard for eye protection against intense light sources, in cosmetic and medical applications (ISO 12609‐1), does exclude lenses identified as affecting clinical color‐related decisions significantly.ConclusionsAny recommendation or standard for eye and face protection for persons making color‐ contingent clinical decisions must include the requirement of ISO 12909‐1. Persons making color‐contingent clinical decisions should be advised to use only untinted or neutral‐colored lenses.Clinical SignificanceThis research is intended to advise writers of standards and recommendations on eye and face protection for use where color‐contingent clinical decisions are made to ensure that the protector does not interfere with these decisions. It is also intended to advise on the selection of tints in their eye protection.