bluuebunny/crossref_metadata_2025_split huggingface dataset:
OUTCOME OF USING PLATELET, PLASMA AND GROWTH FACTORS AS AN ORTHOBIOLOGIC DERIVATIVE TO AVOID INVASIVE SURGICAL PROCEDURES FOR TREATING KNEE OSTEOARTHRITIS AMONG ELDERLY PATIENTS
Authors: Turjane Thana , Saengsirinavin Pamok , Sriratanavudhi Chaivat , Cheeva-akrapan Vorasilp , Larpaiwong Wanpen , Aojanepong Jongjate 
Published: April 2022

Background: The application of platelet, plasma and growth factors (PP&GF) is an intra-articular orthobiologic intervention that has been proven to be safe, having less systemic complications compared with conventional treatments and could constitute an option for treating elderly patients with knee osteoarthritis (OA). However, an intermediate result of using PP&GF has yet to be well established.
Objectives: This study aimed to report the survival analysis of 24-month follow-up treatment using PP&GF among elderly patients with knee OA as primary outcome. The secondary outcomes were functional improvement in terms of international knee documentation committee (IKDC) score, Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score and visual analog scale (VAS) pain score.
Methods: A prospective cohort study was performed among patients with knee OA (Kellgren and Lawrence (KL) grade I-IV), aged more than 65 years who did not respond to conservative treatments. All patients received intra-articular PP&GF treatment and were followed up to 24 months. Primary outcome was recorded as any surgical treatment at any time point post-PP&GF injection. Secondary outcomes including IKDC, WOMAC and VAS pain score were also assessed.
Results: A total of 184 participants were enrolled in this study. The overall survival rate of patients not undergoing any surgical procedures during 24-month follow-up was 87.50%±2.44%. The mean IKDC, WOMAC and VAS pain scores were 39.59±0.58, 55.9±1.09 and 6.63±0.13, respectively at baseline while those at 24-month follow-up were 46.77±0.81, 38.32±1.33 and 4.92±0.13, respectively. The mean platelet concentrations before and after centrifugation were 1.85x105 cells/μL (1.20-3.36x105 cells/μL) and 1.4x106 cells/μL (5.80x105-3.5 x106) cells/μL, respectively, which showed final PP&GF products contained 6-10 times higher platelet concentration than those in the peripheral blood.
Conclusion: Intra-articular injection of PP&GF is a potential treatment for severe knee OA especially among elderly patients. This method provided 87.50% survivorship from surgical intervention at 24-month follow-up. Most patients improved both pain and functional outcomes. We propose that the optimal preparation technique for PP&GF is the key step for improving patients’ clinical outcomes and regaining their quality of lives.
Pemberdayaan Masyarakat: Peningkatan Usaha Desa Berbasis Keunggulan Lokal di Desa Santan Tengah Kabupaten Kutai Kartanegara
Authors: Budiman Budiman , Alaydrus Anwar , Jumansyah Jumansyah , Syarifuddin Tengku Imam , Wahyuni Anita 
Published: April 2022

Abstrak

Meningkatkan peluang dan potensi usaha desa berbasis keunggulan lokal bertujuan untuk mengoptimalkan pembangunan Desa Santan Tengah dengan menggali potensi desa Santan Tengah yang kurang diketahuai oleh pemerintah desa dan diminati oleh masyarakat, sehingga kedepan desa Santan Tengah dapat menjadi desa mandiri melalui keunggulan lokal. Tahap awal kegiatan, akan dilakukan pembahasan awal dengan pihak pemerintah desa untuk mendapatkan gambaran umum terkait desa Santan Tengah, selanjutnya akan dilakukan survei potensi desa dengan kerja sama pihak desa. Tahap selanjutnya dari hasil survei tersebut dilakukan pembahasan bersama pihak desa dan beberapa perwakilan masyarakat untuk menentukan skala prioritas keunggulan desa yang dapat memberikan dampak signifikan terhadap pembangunan desa kedepan melalui usaha desa. Kemudian di sosialisasikan kepada masyarakat dalam rangka meciptakan kesadaran akan keunggulan desa yang dapat menjadi peluang dan potensi kemandirian ekonomi masyarakat desa. Luaran dari kegiatan ini berupa rekomendasi perencanaan strategis peningkatan uasaha desa, publikasi tulisan penciptaan desa madiri dan rencana prioritas usaha desa akan isosialisasikan secara daring dan luring secara berkelanjutan agar masayarakat dapat aktif dalam mendukung rencana peningkatan usaha desa Santan Tengah. Dari kagiatan pengabdian masyarakat ini memberikan manfaat kepada pemerintah desa dan masyarakat di desa Santanh Tengah berupa kemudahan dalam merencanakan alternatif perencanan strategis peningkatan usaha desa berbasis keunggulan lokal yaitu usaha minyak kelapa dan usaha pemasokan tandan buah segar (TBS) kelapa sawit hasil produksi perkebunan masyarakat kepada perusahaan pengelolah buah sawit.
Kegiatan Pelatihan Retorika Public Speaking untuk Profesi Psikologi
Authors: Hairunnisa Hairunnisa , Nurrahim Irsalinda Wesa , Syahidah Shiba Syahidah , Rifaldi Ahmad Naufal , Al-Hadad Muhammad Naufal 
Published: April 2022

Mahasiswa S1 Psikologi merupakan bagian dari masa depan bangsa yang diharapkan mampu memberikan teladan dalam kepemimpinan di masyarakat luas. Setiap prilaku dan ucapan yang disampaikan diharapkan menjadi contoh dan teladan yang baik untuk masyarakatnya. Agar hal tersebut terlaksana dengan baik maka diperlukan dan menjadi keharusan untuk dibekali keterampilan berbicara yang baik dan santun, sehingga mereka mampu menjadi tenaga-tenaga pamong yang handal, kompeten, tangguh dan professional dalam menangani permasalahan-permasalahan masyarakat dan memberikan pelayanan kepada public. Strategi yang digunakan dalam kegiatan pelatihan Public Speaking untuk profesi psikologi ini ialah menggunakan Focus Group Discussion (FGD). FGD itu sendiri ialah diskusi terfokus dari suatu grup dalam membahas suatu masalah tertentu. Diharapkan setelah ini Mahasiswa mendapatkan manfaat secara komprehensif dalam keterampilan dasar dan lanjutan untuk penerapan kepiawaian berbicara yang baik dan santun dihadapan public sehingga menjadi motivator/interest rekan sejawat di lingkungan kampus.

Kata Kunci : Profesi Psikologi, Ilmu komunikasi, Public Speaking
Abstract:
Undergraduate Psychology students are part of the nation's future who are expected to be able to provide role models in leadership in the wider community. Every behavior and speech conveyed is expected to be a good example and role model for the community. In order for this to be carried out properly, it is necessary and imperative to be equipped with good and polite speaking skills, so that they are able to become reliable, competent, tough and professional civil servants in dealing with community problems and providing services to the public. The strategy used in the Public Speaking training for the psychology profession is to use a Focus Group Discussion (FGD). FGD itself is a focused discussion of a group in discussing a particular problem. It is hoped that after this students will get comprehensive benefits in basic and advanced skills for the application of good and polite speaking skills in front of the public so that it becomes a motivator / interest for colleagues in the campus environment.

Keyword: Profession Psychology, Communication Studies, Public Speaking
Radically Networked Societies: The case of the farmers’ protests in India
Authors: Waghre Prateek 
Published: April 2022

This paper analyses India’s ongoing farmer protests movement through the lens of the Radically Networked Societies (RNS) framework. Building on prior RNS-based case studies, the paper contends that this movement is marked by a combination of allied and opposing RNS groups. These RNS groups are characterised by the existence of overlapping identities operating across a mix of existing and instantaneous networks coalescing around their respective common causes of opposing the three farm laws enacted by the Union government and opposing this opposition itself. The ensuing interactions result in amplifying and sustaining adjacent and opposite RNS groups. The paper concludes that the hitherto weak bonds underlying spontaneous networked movements will be supported by hardening ties based on political identities that also transcend international boundaries. This can result in sharper responses by states which may be tempered by international pressure or scrutiny in the short term. Alternatively, an increasing number of protest movements for extended periods could lead to a flattening of responses and waning levels of attention.
A Selective Review of Lipid Autoxidation and Rancidity, Antioxidants, and Dithiooxamide
Authors: Phan Seamus C. C. 
Published: April 2022

Background: The authors had a research interest in antiaging, oxidation and antioxidants, and determined that lipids are some of the more common raw materials in foods, cosmetics, and in humans, and would be an area to explore autoxidation, whether in retarding spoilage, or to slow aging.
Objective: The authors selected a few lipids and tested them against common pro-oxidants, and documented the effects of common antioxidants as well as a proposed antioxidant candidate together with a short-term toxicity study.
Methods: The authors subjected the lipids to elevated temperatures, with a control, and various pro-oxidants, as well as some commercial antioxidants, and the antioxidant candidate. The authors subsequently tested the lipids for by-products of oxidation, and used mice for a short-term toxicity study.
Results: Lipids stored in iron, copper, and other heavy metals, or are contaminated with such metals, are prone to accelerated autoxidation. Aluminium seems to provide an induction period to lipids and does not accelerate autoxidation as other metals do. When compared to antioxidants such as vitamin E, BHA, BHT, and PG, the antioxidant candidate dithiooxamide appears to be a proficient antioxidant and free from short-term toxicity in a small sample study, which were far below the LDLo and LD50 conducted on rats and mice using dithiooxamide in other later published studies.
Conclusions: The authors determined that lipids should steer clear of iron, copper and other heavy metals, and suggest that the antioxidant candidate dithiooxamide in low quantities may be useful for external lipid applications.
Epidemiological and Clinical Presentation of Dengue Infection in the Gadap Region of Karachi. A Survey Based Study
Authors: Azhar Shazia , Nasir Syeda Shabana , Turab Syed Mohsin , Abbas Hina , Memon Shaima Sultana , Qadeer Nimra 
Published: April 2022

Introduction: Dengue fever has emerged as a major arboviral disease with a significant impact oF the disease burden in tropical countries.
Aim: The goal of this study was to look at the clinical and laboratory profiles of dengue infection.
Methodology: During 2018 and 2019; a cross-sectional study was conducted to investigate the epidemiological and clinical features of dengue fever in the Gadap region of Karachi, Pakistan.
Results: Positive cases were reported during the study period, which spanned the months of August to December following the monsoon season. Among the 200 positive patients, 160 had dengue fever (DF) and 40 had dengue hemorrhagic fever (DHF) (male 160 and female 40). Fever was the most common symptom, followed by Arthralgia/Myalgia, Headache, and Vomiting. Patients with Dengue Hemorrhagic Fever had a higher rate of haemorrhage. Thrombocytopenia and leucopenia were discovered to be common laboratory findings in patients with Dengue fever and Dengue hemorrhagic fever.
Conclusion: Clinical and laboratory characteristics of dengue cases studied could be used to identify patients at risk of severe dengue fever early on.
Spatially Selective Monitoring of Subcellular Enzyme Dynamics in Response to Mitochondria‐Targeted Photodynamic Therapy
Authors: Yu Fangzhi , Shao Yulei , Chai Xin , Zhao Yuliang , Li Lele 
Published: April 2022

AbstractTracking spatial and temporal dynamics of bioactive molecules such as enzymes responding to therapeutic treatment is highly important for understanding of the related functions. However, in situ molecular imaging at subcellular level during photodynamic therapy (PDT) has been hampered by the limitations of existing methods. Herein, we present a multifunctional nanoplatform (termed as UR‐HAPT) that is able to simultaneously monitor subcellular dynamics of human apurinic/apyrimidinic endonuclease 1 (APE1) during the near‐infrared (NIR) light‐mediated PDT. UR‐HAPT was constructed by the combination of an upconversion nanoparticle‐based PDT design and a mitochondria‐targeting strategy with an APE1‐responsive DNA reporter. Benefiting from the gain‐of‐function approach, activatable mitochondrial accumulation of APE1 in response to the oxidative stress was observed during the NIR light‐triggered, mitochondria‐targeted PDT process. We envision that this nanoplatform can be applicable to screen and evaluate potential enzyme inhibitors to improve the PDT efficacy.
Avoiding Structural Collapse to Reduce Lead Leakage in Perovskite Photovoltaics
Authors: Wei Xueyuan , Xiao Mengqi , Wang Boyu , Wang Chenyue , Li Yuekang , Dou Jing , Cui Zhenhua , Dou Jie , Wang Hailiang , Ma Sai , Zhu Cheng , Yuan Guizhou , Yang Ning , Song Tinglu , Zhou Huanping , Chen Haining , Bai Yang , Chen Qi 
Published: April 2022

AbstractPerovskite solar cells (PSCs) have become a promising candidate for the next‐generation photovoltaic technologies. As an essential element for high‐efficiency PSCs however, the heavy metal Pb is soluble in water, causing a serious threat to the environment and human health. Due to the weak ionic bonding in three‐dimensional (3D) perovskites, drastic structure decomposition occurs when immersing the perovskite film in water, which accelerates the Pb leakage. By introducing the chemically stable Dion‐Jacobson (DJ) 2D perovskite at the 3D perovskite surface, the film dissolution is significantly slowed down, which retards lead leakage. As a result, the Pb contamination is dramatically reduced under various extreme conditions. In addition, the PSCs device deliver a power conversion efficiency (PCE) of 23.6 % and retain over 95 % of their initial PCE after the maximum power point tracking for over 1100 h.
Design of Stimuli‐Responsive Phenothiazine Derivatives with Triplet‐Related Dual Emission and High‐Contrast Mechanochromism Guided by Polymorph Prediction
Authors: Zhang Jiayu , Zhu Mengna , Lu Yunxiang , Zhang Xinghong , Xiao Shuzhang , Lan Haichuang , Yi Tao 
Published: April 2022

AbstractThe development of high‐contrast stimulus‐responsive materials with excited triplet emission is of great significance for anti‐counterfeiting, sensor and memory applications, but remains a challenge. Here, we report a strategy for the rational design of stimulus‐responsive phenothiazine derivatives with triplet‐related dual emissions and high‐contrast mechanochromism guided by Polymorph Prediction. The designed phenothiazine derivatives have the characters of simple structures, a facile synthetic procedure, and a good crystalline nature. We found that the crystals of those derivatives with the potential to form both quasi‐axial (ax) and quasi‐equatorial (eq) conformations could undergo conformation transition and show significant emission difference (Δλem>100 nm) under mechanical force. Meanwhile, all these phenothiazine derivatives exhibit aggregation‐induced emission and emit room‐temperature phosphorescence or thermally activated delayed fluorescence. The significant luminescent change of these materials under different stimuli gives them promise for applications in encryption and anti‐counterfeiting.
Relativistic Spin–Orbit Electronegativity and the Chemical Bond Between a Heavy Atom and a Light Atom
Authors: Cuyacot Ben Joseph R. , Novotný Jan , Berger Raphael J. F. , Komorovsky Stanislav , Marek Radek 
Published: April 2022

AbstractRadek Marek and his co‐workers at Masaryk University, Brno, Czechia have been invited to prepare the cover of this issue. The image depicts the relativistic spin–orbit coupling that is associated with the presence of a heavy atom in a molecule influencing the electron density around a light atom and modulating the chemical bond between these two atoms. Read the full text of the article at 10.1002/chem.202200277.
Prediction of geoid undulations: Random forest versus classic interpolation techniques
Authors: Akar Alper , Konakoğlu Berkant , Akar Özlem 
Published: April 2022

AbstractLocal geoid determination studies are commonly carried out today to establish the relationship between the ellipsoidal height determined by satellite geodesy methods and the orthometric height found using geoid undulation . The aim of this study was to determine a local geoid using the kriging, local polynomial (LP), and inverse distance to a power (IDP) interpolation methods along with the random forest (RF) regression method and to compare the performance. For the application, 193 Global Navigation Satellite System (GNSS)/leveling points homogeneously distributed over the study area were selected as reference data, and 70 GNSS/leveling points were selected as test data. The results were compared in terms of accuracy using well‐known performance metrics, namely, the root mean square error (RMSE), mean absolute error (MAE), and coefficient of determination (R2) values. According to the results, the highest R2 and the lowest RMSE and MAE values were obtained with the RF regression method. These findings demonstrated the superiority of the RF regression over the classic interpolation methods applied in the local geoid determination for the study area.
A bartering double auction resource allocation model in cloud environments
Authors: Ghasemian Koochaksaraei Mohammad Hossein , Toroghi Haghighat Abolfazl , Rezvani Mohammad Hossein 
Published: April 2022

AbstractResource provisioning and allocation are two essential operations of cloud service providers (CSPs). Due to limited resources, it may sometimes not be cost‐effective for CSPs to obtain them from the market. On the other hand, releasing some less profitable resources may violate the service level agreement (SLA). This article presents an auction‐inspired model for providing/demanding resources without exchanging money among CSPs. The core idea is that CSPs do not need to pay monetary values. Instead, they exchange free resources through an auction mechanism and are encouraged to cooperate. This model, which we call bartering double auction resource allocation, helps CSPs receive the resources they need in the form of virtual machine instances with different types of functionalities. Under this mechanism, if one party violates the SLA, the other takes back its resources to avoid possible loss. The experimental results using the CloudSim simulator and the statistical analyses show that the proposed mechanism can increase CSPs' social welfare and profitability while significantly reducing SLA violations. Also, the proposed model provides four essential economic properties, that is, individual rationality, incentive compatibility, budget balancing, and economic efficiency.
Ultrasound Assisted Formation of the Stable Form of Glycine and Its Mechanism
Authors: Jiang Yujie , Song Yujie , Su Min 
Published: April 2022

AbstractUltrasound is a useful method to obtain the stable form for polymorph systems. The stable crystal form of glycine as a model compound in cooling crystallization using ultrasound is studied. The form of the crystal products is characterized by powder X‐ray diffraction. The influences of ultrasound process parameters, including the ultrasound treating timing, treating mode, power density and duration, on the γ‐glycine in cooling crystallization are conducted. The nucleation moment when a “critical size of cluster” is formed is the most effective moment for the ultrasound treatment, and at the same time produces more stable form. Pulse treating mode can effectively solve the ultrasound thermal effect problem. The total energy input and duration has a peak value in promoting the form transformation in practice. The mechanism of the ultrasound in promoting the stable form formation is also discussed.
Host plants and pollination regions for the long‐distance migratory noctuid moth, Hadula trifolii Hufnagel in China
Authors: He Limei , Liu Yongqiang , Guo Jianglong , Chang Hong , Wu Kongming 
Published: April 2022

AbstractNocturnal moths are important pollinators of plants. The clover cutworm, Hadula trifolii, is a long‐distance migratory nocturnal moth. Although the larvae of H. trifolii are polyphagous pests of many cultivated crops in Asia and Europe, the plant species pollinated by the adult are unclear. Pollen species that were attached to individual migrating moths of H. trifolii were identified based on pollen morphology and DNA to determine their host plants, geographic origin, and pollination areas. The moths were collected on their seasonal migration pathway at a small island, namely Beihuang, in the center of the Bohai Sea of China during 2014 to 2018. Pollen was detected on 28.60% of the female moths and 29.02% of the male, mainly on the proboscis, rarely on compound eyes and antennae. At least 92 species of pollen from 42 plant families, mainly from Asteraceae, Amaranthaceae, and Pinaceae, distributed throughout China were found on the test moths. Migratory H. trifolii moths visited herbaceous plants more than woody plants. Pollen of Macadamina integrifolia or M. tetraphylla was found on moths early in the migratory season. These two species are distributed in Guangdong, Yunnan, and Taiwan provinces in China, indicating that migratory moths probably traveled about 2000 km from southern China to the Beihuang Island in northern China. Here, by identifying plant species using pollen, we gained a better understanding of the interactions between H. trifolii moths and a wide range of host plants in China. This work provides valuable and unique information on the geographical origin and pollination regions for H. trifolii moths.
The potential impacts of invasions on native symbionts
Authors: Creed Robert P. , Brown Bryan L. , Skelton James 
Published: April 2022

AbstractSymbionts, including parasites, pathogens, and mutualists, can play important roles in determining whether or not invasions by host species will be successful. Loss of enemies from the native habitat, such as parasites and pathogens, can allow for higher invader fitness in the invaded habitat. The presence of mutualists (e.g., pollinators, seed dispersers, mycorrhizae, and rhizobial bacteria) in the invaded habitat can facilitate invasion success. Although there has been a great deal of research focusing on how invading hosts may benefit from enemy losses or mutualist gains, far less attention has focused on how native symbiont populations and communities respond to invasion by non‐indigenous hosts and symbionts. In this paper, we present a conceptual framework examining how symbionts such as parasites, pathogens, commensals, and mutualists can influence invader success and whether these native symbionts will benefit or decline during invasion. The first major factor in this framework is the competence of the invading host relative to the native hosts. Low‐ or non‐competent hosts that support few if any native symbionts could cause declines in native symbiont taxa. Competent invading hosts could potentially support native parasites, pathogens, commensals, and mutualists, especially if there is a closely related or similar host in the invaded range. These symbionts could inhibit or facilitate invasion or have no discernible effect on the invading host. An understanding of how native symbionts interact with competent versus non‐competent invading hosts as well as various invading symbionts is critical to our understanding of invasion success, its consequences for invaded communities and how native symbionts in these communities will fare in the face of invasion.