bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis
Authors: Wang Weijie , Qi Guangzhao , Zhao Xiangtian , Zhang Yanping , Zhu Rongtao , Liang Ruopeng , Sun Yuling 
Published: February 2022

ObjectiveLittoral cell angioma (LCA) is currently considered to be a rare splenic tumor with malignant potential. As the epidemiology, pathogenesis, clinical manifestation, treatment, and prognosis remain unclear, the clinical diagnosis and treatment of LCA have not been standardized. Hence, we performed a comprehensive analysis of 189 observational studies comprising 435 patients to improve the current status of diagnosis and treatment.MethodsPubMed, Embase, WanFang and CNKI were searched from inception to May 2021 to identify LCA studies that were published in English and Chinese. The clinical information of LCA patients were extracted and analyzed.ResultsThe LCA has a male-to-female ratio of 0.90 and a solitary-to-multiple ratio of 0.31. In terms of clinical features, 69.7% of the patients showed splenomegaly, 49.7% were asymptomatic, and 39.2% experienced epigastric discomfort. As the imaging findings of patients with LCA were nonspecific, an image-guided biopsy (10/12) was a safe and effective method for diagnosing in this condition. Notably, results of the prognostic analysis indicated that LCA has a lower risk of recurrence and metastasis. The patient may develop a stable disease or the tumor will grow but will not metastasize. Besides, the novel immunohistochemical pattern of LCA was described as CD31+/ERG+/FVIII Antigen+/CD68+/CD163+/lysozyme+/CD8−/WT1−.ConclusionLCA should be reconsidered as a benign primary splenic vascular neoplasm, which is more like an intra-splenic manifestation of abnormal body function. Image-guided biopsy with follow-up might be a beneficial choice for LCA patients. For LCA patients with abdominal discomfort, pathological uncertainty or continuous tumor enlargement, splenectomy remains the preferred treatment.
Comparison of Synthetic Computed Tomography Generation Methods, Incorporating Male and Female Anatomical Differences, for Magnetic Resonance Imaging-Only Definitive Pelvic Radiotherapy
Authors: O’Connor Laura M. , Choi Jae H. , Dowling Jason A. , Warren-Forward Helen , Martin Jarad , Greer Peter B. 
Published: February 2022

PurposeThere are several means of synthetic computed tomography (sCT) generation for magnetic resonance imaging (MRI)-only planning; however, much of the research omits large pelvic treatment regions and female anatomical specific methods. This research aimed to apply four of the most popular methods of sCT creation to facilitate MRI-only radiotherapy treatment planning for male and female anorectal and gynecological neoplasms. sCT methods were validated against conventional computed tomography (CT), with regard to Hounsfield unit (HU) estimation and plan dosimetry.Methods and MaterialsPaired MRI and CT scans of 40 patients were used for sCT generation and validation. Bulk density assignment, tissue class density assignment, hybrid atlas, and deep learning sCT generation methods were applied to all 40 patients. Dosimetric accuracy was assessed by dose difference at reference point, dose volume histogram (DVH) parameters, and 3D gamma dose comparison. HU estimation was assessed by mean error and mean absolute error in HU value between each sCT and CT.ResultsThe median percentage dose difference between the CT and sCT was &lt;1.0% for all sCT methods. The deep learning method resulted in the lowest median percentage dose difference to CT at −0.03% (IQR 0.13, −0.31) and bulk density assignment resulted in the greatest difference at −0.73% (IQR −0.10, −1.01). The mean 3D gamma dose agreement at 3%/2 mm among all sCT methods was 99.8%. The highest agreement at 1%/1 mm was 97.3% for the deep learning method and the lowest was 93.6% for the bulk density method. Deep learning and hybrid atlas techniques gave the lowest difference to CT in mean error and mean absolute error in HU estimation.ConclusionsAll methods of sCT generation used in this study resulted in similarly high dosimetric agreement for MRI-only planning of male and female cancer pelvic regions. The choice of the sCT generation technique can be guided by department resources available and image guidance considerations, with minimal impact on dosimetric accuracy.
No Association Between Maternal Post-partum Depression and Vaccination Uptake of Infants: A Matched Cohort Study in a Large Health Maintenance Organization Database in Israel
Authors: Zaikin Ariela , Koren Gideon , Chodick Gabriel , Grossman Zachi 
Published: February 2022

BackgroundMaternal post-partum depression is one of the most common medical complications around childbirth. One of its consequences is a possible association with children's receipt of preventive health care, including immunization. This study aimed to explore the association between maternal postpartum depression and children's immunization rates.MethodsA retrospective cohort study of Maccabi Healthcare Services (HMO) members comparing immunization rates between children born between 2006 and 2019 to mothers with post-partum depression and children born to mothers with no documented depression. Post-partum depression was assessed by Edinburgh Postnatal Depression Scale, a 10-item questionnaire considered the screening tool of choice in Israel for early Post-partum detection. 1:1 matching was conducted according to criteria: age of the mother ± 2 years, child's year of birth, the newborn baby's gender, the baby's birth order and socioeconomic index. The primary outcome was defined as non-vaccination and the exposure was defined as depression. A sub-analysis was performed, comparing immunization rates of children born to mothers treated with antidepressant medications to rates of children born to untreated mothers.ResultsA total of 709 subjects in the exposed cohort (children born to mothers with post-partum depression symptoms) and 681 subjects in the matched cohort were analyzed. The relative risks among children born to depressed mothers compared with children born to healthy mothers for not receiving any vaccine at 2 months, three doses of pertussis vaccine up to 7 months and four doses of DTaP-Hib-IPV vaccine up to 18 months were 1.15 (95% CI 0.74–1.78), 1.11 (95% CI 0.94–1.31) and 0.82 (95% CI 0.56–1.95), respectively. The relative risks among 139 infants born to treated mothers compared with 570 infants born to untreated mothers for not receiving any vaccine at 2 months, three doses of pertussis vaccine up to 7 months and four doses of DTaP-Hib-IPV vaccine up to 18 months were 1.28 (0.64–2.54), 0.78 (0.57–1.06) and 0.42 (0.17–1.03), respectively.ConclusionWe found no significant association between maternal post-partum depression and uptake of child Immunization.
Development and Validation of a Prognostic Score for Hepatocellular Carcinoma Patients in Immune Checkpoint Inhibitors Therapies: The Hepatocellular Carcinoma Modified Gustave Roussy Immune Score
Authors: Li Yongjiang , Pan Yangxun , Lin Ximeng , Hou Jingyu , Hu Zili , Xu Li , Zhou Zhongguo , Zhang Yaojun , Chen Minshan , Hu Dandan 
Published: February 2022

Background: There is not yet an effective marker in predicting the efficacy of immune checkpoint inhibitors (ICIs) in treating hepatocellular carcinoma (HCC) patients. The Gustave Roussy Immune Score (GRIm-Score) based on three objective variables, namely, neutrophil-to-lymphocyte ratio (NLR), serum albumin level (ALB), and lactate dehydrogenase (LDH), was developed as feasible prognostic indication in lung cancer patients receiving ICIs therapies. Our study aimed to adapt the GRIm-Score (HCC-GRIm-Score) in HCC patients who received ICIs therapies and thus improving the predictive ability.Methods: From January 2018 to September 2020, 261 patients who received ICIs therapy were retrospectively included and divided into training and validation groups. After determining the factors for HCC-GRIm-Score by multivariable analysis from training group, the optimized HCC-GRIm-Score was validated and compared to the original GRIm-Score and the Barcelona clinic liver cancer (BCLC) staging system.Results: One hundred sixty-one and 80 patients were assigned into the training and validation groups, respectively. Two more factors, aspartate transaminase-to-alanine transaminase ratio [hazard ratio (HR), 1.51; 95% confidence interval (CI), 0.94–2.42] and total bilirubin (HR, 1.76; 95% CI, 1.07–2.88), were identified as independent prognostic factors for overall survival (OS) and integrated in the HCC-GRIm-Score system according to the multivariable analysis. A risk score based on the HCC-GRIm-Score indicated that patients presenting high score (&gt;2) suffered from significantly shorter median OS of 10.3 months compared to those with a low score (not reached; HR, 2.99; 95% CI, 1.89–4.75; p &lt; 0.001). In the validation group of 80 patients, the patients presenting a high score showed an inferior OS (HR 5.62, 95% CI, 1.25–25.24; p = 0.024). HCC-GRIm-Score had the highest area under curve of 0.719 (95% CI, 0.661–0.773) compared to original GRIm-Score and BCLC staging system.Conclusion: The present study confirmed that the modified HCC-GRIm-Score system provided superior predictive ability in identifying the HCC patients potentially benefit from ICIs therapies, compared to the original GRIm-Score and the BCLC staging system.
Evaluation of Laser Confocal Raman Spectroscopy as a Non-Invasive Method for Detecting Sperm DNA Contents
Authors: Li Mengge , Ji Yaxing , Wang Dongmei , Zhang Yanliang , Zhang Huan , Tang Yi , Lin Ge , Hu Liang 
Published: February 2022

Research QuestionIs Raman spectroscopy an efficient and accurate method to detect sperm chromosome balance state by DNA content differences?DesignSemen samples were provided by diploid healthy men, and the analysis parameters met the current World Health Organization standards. The DNA content was assessed by analysis of the corresponding spectra obtained from a laser confocal Raman spectroscope. The sperm sex chromosome information was obtained by fluorescence in situ hybridization (FISH). Comparative analysis was performed between FISH results and Raman spectral analysis results.ResultsDifferent parts of the sperm head showed different spectral signal intensities, which indicated that there were different chemical components. Standard principal component analysis (PCA) can preliminarily classify sperm with different DNA contents into two groups. Further analysis showed that there were significant differences in the 785 DNA backbone peaks and 714–1,162 cm−1 DNA skeleton regions among sperm with different DNA contents. The peak and regional peak of the DNA skeleton of X sperm were significantly higher than those of Y sperm (X vs. Y, p &lt; 0.05). The above sperm types were confirmed by FISH. ROC curve analysis shows that there is a correlation between the Raman spectrum data and FISH results.ConclusionRaman spectroscopy can identify X and Y sperms by analyzing the DNA content difference. However, the accuracy of the detection still needs to be improved. Nevertheless, Raman spectroscopy has a potential application value in the field of sperm aneuploidy detection and may even be used as a non-invasive predictor of sperm aneuploid state in preimplantation genetic testing (PGT-A).
Can Primary School Mathematics Performance Be Predicted by Longitudinal Changes in Physical Fitness and Activity Indicators?
Authors: Sember Vedrana , Jurak Gregor , Starc Gregor , Morrison Shawnda A. 
Published: February 2022

ObjectiveTo determine to what extent physical fitness indicators and/or moderate to vigorous physical activity (MVPA) may account for final mathematics academic performance (APmath) awarded at the end of primary school.MethodsSchool-aged youth were sampled in a repeated-measures, longitudinal design in Grade 6 (∼11 years), and again in Grade 9 (∼14 years). The youth (N = 231, 111 girls) completed a fitness test battery consisting of: flamingo balance test, standing long jump, backward obstacle course, plate tapping, sit ups, sit and reach, handgrip, and 20-m shuttle run. APmath scores were obtained for all children at the end of Grade 5, end of Grade 8, and end of Grade 9 (their final year of primary school). In a sub-sample of Grade 6 youth (N = 50, 29 girls), MVPA was measured objectively via SenseWear Pro Armbands (MVPAOB) for seven consecutive days, with measurements repeated in Grade 9.ResultsMath scores decreased from Grade 6 to 9 for both boys and girls (95%CI: −0.89 to −0.53, p &lt; 0.001). MVPAOB was reduced by ∼45.7 min (−33%) from Grade 6 to 9 (p &lt; 0.01). Significant main and interaction effects are noted for each fitness indicator (p &lt; 0.05). A backward stepwise multiple regression analysis determined significant shared variance in final APmath grade to the change scores from Grade 6 to Grade 9 in: ΔAPmath, Δbackward obstacle course, Δsit and reach, and Δsit-ups [R2 = 0.494, F(4,180) = 43.67, p &lt; 0.0001]. A second regression was performed only for the youth who completed MVPAOB measurements. In this sub-sample, MVPAOB did not significantly contribute to the model.ConclusionLongitudinal changes in youth fitness and their delta change in APmath score accounted for 49.4% of the variance in the final math grade awarded at the end of Grade 9. Aerobic power, upper body strength, and muscular endurance share more common variance to final math grade in boys, whereas whole-body coordination was the more relevant index in girls; this finding suggests that future research exploring the relationship of AP and PF should not be limited to cardiorespiratory fitness, instead encompassing muscular and neuro-muscular components of PF.
Impact of Pulmonary Arterial Hypertension on Employment, Work Productivity, and Quality of Life - Results of a Cross-Sectional Multi-Center Study
Authors: Fuge Jan , Park Da-Hee , von Lengerke Thomas , Richter Manuel J. , Gall Henning , Ghofrani Hossein A. , Kamp Jan C. , Hoeper Marius M. , Olsson Karen M. 
Published: February 2022

IntroductionData on burden of pulmonary arterial hypertension (PAH) are mostly limited to physical and clinical endpoints as well as quality of life. Research on employment, work productivity, and educational background is scarce. The aim of this study was to assess the impact of PAH on employment status and work productivity in Germany.Materials and MethodsIn a multicenter cross-sectional survey, patients with PAH were surveyed in two large pulmonary hypertension referral centers in Germany. The survey contained questions on education, employment, work productivity and impairment (WPAI, also at the time of diagnosis), quality of life, and socioeconomic status. Additional data was assessed using clinical research database for 6-min walk distance (6MWD), WHO functional class, and N-terminal fragment of pro-brain natriuretic peptide. All patients provided written informed consent, and the institutional review board approved this study.ResultsIn total, 212 patients were surveyed (72% female; median, 57 years) approximately 6 years after initial PAH diagnosis. A total of 76% had an idiopathic PAH followed by hereditary and associated PAH (10% each). Employment at the time of diagnosis was 48% (34% full-time, 14% part-time), with productivity measured by a WPAI score of 6 points and decreased to 29% (21% full-time, 8% part-time) at the time of the survey (with a WPAI score of 2 points, p &lt; 0.001). Logistic regression showed education and 6MWD as predictors for employment. Patients in moderate or high educational category had a 3.6- or 5.6-fold chance, respectively, of being employed (p = 0.025 and p = 0.019), and per 50-m increase of 6MWD, the odds of being employed were 1.2, p = 0.042.ConclusionPatients with PAH had a reduced employment rate, which was influenced by education and 6MWD. There was a considerable loss of employment over the course of the disease. Employment should be one possible treatment goal in patients with PAH to provide social participation to this patient group.
The Effect of Intraoperative Transversus Abdominis Plane Blocking on Postoperative Pain After Laparoscopic Transabdominal Pre-peritoneal (TAPP) Groin Hernia Repair
Authors: Chamzin Alexandros , Frountzas Maximos , Gkiokas George , Kouskouni Evaggelia , Xanthos Theodoros , Michalopoulos Nikolaos V. 
Published: February 2022

BackgroundManaging postoperative pain even after laparoscopic groin hernia repair still remains an interesting challenge for clinicians especially for patients of high risk. Plenty of operative techniques and analgesic methods have been proposed in order to minimize postoperative pain after laparoscopic groin hernia repair. The aim of the present study is to compare transverse abdominis plane (TAP)-block with local analgesic infiltration at trocar entry sites in the terms of reducing postoperative pain.MethodsPatients that underwent laparoscopic trans-abdominal pre-peritoneal (TAPP) groin hernia repair in a high-volume university hospital were included. Patients were divided in two groups depending on the analgesic method used. Pain was assessed using Visual Numerical Scale (VNS) score.ResultsThirty patients were included. Intraoperative TAP-block seemed to be superior in terms of decreasing pain at the hernia area and at the trocar insertion site (p &lt; 0.05) compared to local analgesic infiltration at the trocar insertion site at 6, 12 and 24 h after surgery (p &lt; 0.05). In addition, pain reduction was more effective in rest rather than in motion for both analgesic methods.ConclusionIntraoperative TAP-block under direct vision seems to be an effective, fast and easy technique in order to reduce postoperative pain after laparoscopic groin hernia repair, but more studies are required to validate these results in a prospective and randomized context.
Метод просторово-часового синтезу структури дата-центричної ЗРС
Authors: Скорик Анатолій Борисович , Павленко Максим Анатолійович , Тристан Андрій Вікторович , Моргун Євгеній Валерійович , Звєрєв Олексій Олексійович 
Published: February 2022

У статті розглядаються питання просторово-часового синтезу структури дата-центричної ЗРС під час ведення протиповітряного бою у реальному масштабі часу. Аналізуються особливості побудови загальної архітектури дата-центричних систем-систем, розрізнення фізичного і кібернетичного простору існування ЗРС. Приведена загальна схема формування структури ЗРС і схема методу синтезу комплексної моделі функціонування засобів ЗРС в складі контуру наведення ЗКР. Розглянуті питання обліку обмежень просторово-часового синтезу структури ЗРС з урахуванням можливої деградації фізичної топології.
Research Institute of Maternity and Childhood Protection is 90 Years Old
Authors: Шишко Г.А. , Вильчук К.У. , Васильев С.А. 
Published: February 2022

В статье приведена история становления в нашей стране научных исследований и медицинской помощи матерям и детям начиная c 1931 г. и до настоящего времени. Научная и организационно-методическая деятельность коллектива научно-исследовательского института охраны материнства и детства способствовала повышению качества медицинского обслуживания населения, уменьшению заболеваемости и детской смертности в республике, повышению качества оказания медицинской помощи матерям и детям. Представлены структура, основные направления научных исследований и ведущие специалисты научно-исследовательского института охраны материнства и детства, который в 2004 г. в результате реорганизации вошел в структуру головного учреждения республики в области акушерства и гинекологии, педиатрии и медицинской генетики - государственного учреждения «Республиканский научно-практический центр «Мать и дитя» Министерства здравоохранения Республики Беларусь.
The article describes the history of the formation of scientific research and medical care for mothers and children in our country from 1931 to the present. Scientific, organizational and methodological activities of the research institute for the protection of mothers and children contributed to improving the quality of medical services for the population, reducing morbidity and infant mortality in the republic, improving the quality of medical care for mothers and children. The structure, main directions of scientific research and leading specialists of the research institute for the protection of mothers and children are presented, which in 2004, as a result of reorganization, entered the structure of the head institution of the republic in the field of obstetrics and gynecology, pediatrics and medical genetics - the state institution “Republican Scientific and Practical Center “Mother and Child” of the Ministry of Health of the Republic of Belarus.
Concentration of Nitrogen Oxide and the Outcome of Induced Delivery
Authors: Васильев С.А. , Пересада О.А. , Курлович И.В. , Ващилина Т.П. , Семенчук В.Л. , Виктор С.А. 
Published: February 2022

Цель исследования. Выявить зависимость между концентрацией оксида азота в сыворотке крови беременных женщин и исходами индуцированных родов. Материалы и методы. Проведен проспективный анализ родов у 80 женщин, которым выполнялась индукция родовой деятельности в государственном учреждении «Республиканский научно-практический центр «Мать и дитя» (далее - РНПЦ «Мать и дитя») в 2020-2021 гг. Была установлена зависимость исходов индуцированных родов от концентрации оксида азота в сыворотке крови беременных женщин. Результаты. По результатам проведенного исследования была выявлена прямая корреляционная зависимость умеренной силы между балльной оценкой степени зрелости шейки матки по шкале Bishop и концентрацией оксида азота (rs=0,40, р<0,001) и обратная корреляционная зависимость умеренной силы между длиной сомкнутой части шейки матки и концентрацией оксида азота (rs=-0,36, р=0,001). С помощью ROC-анализа было рассчитано пороговое значение оксида азота в сыворотке крови для прогнозирования успешного исхода индукции родов, которое составило 70,5 mM/л и более с чувствительностью 60% и специфичностью 80%. Выводы. Определение оксида азота в сыворотке крови при решении вопроса о родоиндукции может быть полезным для прогнозирования успешного исхода родоиндукции при пороговом значении 70,5 mM/л и более с чувствительностью 60% и специфичностью 80%.
The aim of the study. To identify the relationship between the concentration of nitric oxide in the serum of pregnant women and the outcomes of induced labor. Methods. A prospective analysis of 80 women who underwent induction of labor in the Republican Scientific and Practical Center “Mother and Child” in 2020-2021 was carried out. The relationship between the outcomes of induced labor and the concentration of nitric oxide in the serum of pregnant women was established. Results. According to the results of the study, a direct correlation dependence of moderate strength between the score of the degree of maturity of the cervix on the Bishop scale and the concentration of nitric oxide (rs=0.40, p<0.001) and an inverse correlation dependence of moderate strength between the length of the closed part of the cervix and the concentration of nitric oxide (rs=-0.36, p=0.001). Using the ROC analysis, the threshold value of nitric oxide in the blood serum was calculated to predict the successful outcome of labor induction, which was 70.5 mM/L or more with a sensitivity of 60% and a specificity of 80%. Conclusions. The determination of nitric oxide in the blood serum when deciding on induction of labor can be useful for predicting the successful outcome of induction of labor at a threshold value of 70.5 mM/L or more with a sensitivity of 60% and a specificity of 80%.