bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in Metastatic Prostate Cancer Following Progression on Androgen-Targeting Therapies
Authors: Zurita Amado J. , Graf Ryon P. , Villacampa Guillermo , Raskina Kira , Sokol Ethan , Jin Dexter , Antonarakis Emmanuel S. , Li Gerald , Huang Richard S. P. , Casanova-Salas Irene , Vivancos Ana , Carles Joan , Ross Jeffrey S. , Schrock Alexa B. , Oxnard Geoffrey R. , Mateo Joaquin 
Published: July 2022

PURPOSETo study the impact of standard-of-care hormonal therapies on metastatic prostate cancer (mPC) clinical genomic profiles in real-world practice, with a focus on homologous recombination-repair (HRR) genes.PATIENTS AND METHODSTargeted next-generation sequencing of 1,302 patients with mPC was pursued using the FoundationOne or FoundationOne CDx assays. Longitudinal clinical data for correlative analysis were curated via technology-enabled abstraction of electronic health records. Genomic biomarkers, including individual gene aberrations and genome-wide loss-of-heterozygosity (gLOH) scores, were compared according to biopsy location and time of sample acquisition (androgen deprivation therapy [ADT]-naïve, ADT-progression and post-ADT, and novel hormonal therapies [NHT]-progression), using chi-square and Wilcoxon rank-sum tests. Multivariable analysis used linear regression. False-discovery rate of 0.05 was applied to account for multiple comparisons.RESULTSEight hundred forty (65%), 132 (10%), and 330 (25%) biopsies were ADT-naïve, ADT-progression, and NHT-progression, respectively. Later-stage samples were enriched for AR, MYC, TP53, PTEN, and RB1 aberrations (all adjusted P values < .05), but prevalence of HRR-related BRCA2, ATM, and CDK12 aberrations remained stable. Primary and metastatic ADT-naïve biopsies presented similar prevalence of TP53 (36% v 31%) and BRCA2 (8% v 7%) aberrations; 81% of ADT-naïve BRCA2-mutated samples presented BRCA2 biallelic loss. Higher gLOH scores were independently associated with HRR genes ( BRCA2, PALB2, and FANCA), TP53, and RB1 aberrations, and with prior exposure to hormonal therapies in multivariable analysis.CONCLUSIONPrevalence of HRR-gene aberrations remains stable along mPC progression, supporting the use of diagnostic biopsies to guide poly (ADP-ribose) polymerase inhibitor treatment in metastatic castration-resistant prostate cancer. gLOH scores increase with emerging resistance to hormonal therapies, independently of individual HRR gene mutations.
Music Theory Pedagogy in the Nineteenth Century
Authors: Utne-Reitan Bjørnar 
Published: July 2022

AbstractWhat characterized conservatory music theory pedagogy in nineteenth-century Europe? This article discusses the traditions of music theory pedagogy associated with the conservatories in Paris, Vienna, and Leipzig, specifically focusing on the middle of the nineteenth century (ca. 1830–70). In the first section, the characteristics of the three individual traditions are discussed separately. The second section compares these traditions from three perspectives: theoretical framework, pedagogical approach, and historical legacy. Although the traditions are different on several central points (e.g., ties to Italian partimento pedagogy in Paris, to Ramellian fundamental bass in Vienna, and to Weberian Roman numeral analysis in Leipzig), they also have some fundamental similarities that drew the borders—the defining limits—of conservatory music theory. The author argues that in the nineteenth century the idea of music theory as a primarily written discipline (centered on textbooks and written exercises and largely separated from musical performance) became a central element of these general characteristics of music theory pedagogy that would be taken for granted and accepted as self-evident across institutional traditions.
SMART Registry: Safety and Performance of the Penumbra SMART COIL System for Patients With Intracranial Aneurysms 4 mm and Smaller
Authors: Spiotta Alejandro M. , Bellon Richard J. , Bohnstedt Bradley N. , Park Min S. , Sattur Mithun G. , Woodward B. Keith 
Published: July 2022

BACKGROUND:The Penumbra SMART COIL System includes a novel generation of embolic coils composed of complex and WAVE shape properties with varying levels of softness.OBJECTIVE:To assess safety and efficacy of the SMART COIL System through a 1-year follow-up in patients with small intracranial aneurysms.METHODS:This subset analysis of the SMART Registry, a prospective, multicenter study, includes patients with small intracranial aneurysms (≤4 mm) treated with the SMART COIL System. Registry end points include retreatment rates through 1 year, procedural device-related serious adverse events, and adequate occlusion postprocedure.RESULTS:Of 905 enrolled patients with aneurysms, 172 (19.0%) had small (≤4 mm) aneurysms (75.6% female; mean age 57.2 ± 13.4 years). 30.8% (53/172) of small aneurysms were ruptured, of which 50.9% (27/53) had Hunt and Hess ≥3. 79.5% (132/166) were wide-necked. Stent-assisted coiling and balloon-assisted coiling were performed in 37.2% (64/172) and 22.1% (38/172) of patients, respectively. The mean packing density for very small aneurysms was 44.9 (SD 25.23). Raymond Class I and Class II were achieved in 89.5% (154/172) postprocedure and 97.2% (137/141) at 1 year. The retreatment rate through 1 year was 5.6% (8/142), and the recanalization rate was 7.1% (10/141). The periprocedural device-related serious adverse event rate was 2.9% (5/172). Intraprocedural aneurysm rupture occurred in 0.8% of patients.CONCLUSION:This analysis suggests that the SMART COIL System is safe and efficacious in small aneurysms with satisfactory occlusion rates and low rates of rupture or rerupture. At 1 year, patients had low retreatment rates and good clinical outcomes.
Reoperative Brachial Plexus Neurolysis After Previous Anatomically Complete Supraclavicular Decompression for Neurogenic Thoracic Outlet Syndrome: A 10-Year Single-Center Case Series
Authors: Jammeh Momodou L. , Yang Alexander , Abuirqeba Ahmmad A. , Ohman J. Westley , Thompson Robert W. 
Published: July 2022

BACKGROUND:
Optimal management of recurrent neurogenic thoracic outlet syndrome (NTOS) remains a considerable challenge.

OBJECTIVE:
To assess the safety and effectiveness of reoperative brachial plexus neurolysis in patients with recurrent NTOS.

METHODS:
From 2009 to 2019, 85 patients underwent reoperative supraclavicular brachial plexus neurolysis for recurrent NTOS after a previous anatomically complete supraclavicular decompression. Data from a prospectively maintained database were analyzed retrospectively.

RESULTS:
The mean patient age at reoperation was 36.9 ± 1.3 (range 15-64) years, 75% were female, and the interval after previous primary operation was 2.5 ± 0.2 years. Intervening injury had precipitated recurrent NTOS in 14 patients (16%), and the mean Disability of the Arm, Shoulder, and Hand (QuickDASH) score before reoperation was 65.2 ± 2.6, reflecting substantial disability. Operative findings consisted of dense fibrous scar tissue surrounding/encasing the brachial plexus. Compared with the previous primary operations, reoperations had a shorter operative time (198 ± 4 vs 161 ± 5 minutes, P < .01) and hospital stay (4.4 ± 0.2 vs 3.6 ± 0.1 days, P < .01), but there were no significant differences in the frequency of prolonged hospitalization (7.1% vs 4.7%), early reoperation (3.5% vs 1.2%), or 30-day hospital readmission (8.2% vs 7.1%). During a median follow-up of 4.8 years, QuickDASH scores improved by 23.3 ± 2.6 (34.2% ± 3.6%; P < .01) and patient-rated outcomes were excellent in 24%, good in 42%, fair in 26%, and poor in 8%.

CONCLUSION:
Reoperative supraclavicular brachial plexus neurolysis is technically challenging but safe and effective treatment for recurrent NTOS, with significant improvements in symptoms and function. Diminishing perineural scar tissue development and avoiding secondary injury would likely decrease the need for reoperations.
Using the ROSA Robot for Lesion Resection: A Novel Adapter With Added Applications
Authors: Pruitt Rachel , Goldstein Todd A. , Rodgers Shaun 
Published: July 2022

BACKGROUND:
The ROSA robot (Medtech) has been shown to be a useful instrument in the surgeon's armamentarium for accurate placement of stereotactic electroencephlography depth electrodes. However, it has not yet been used as a navigation tool for lesion resection. Here, we demonstrate a novel adapter that allows the surgeon to use the ROSA robot with the NICO BrainPath for the resection of deep lesions.

OBJECTIVE:
To demonstrate the utility of an adapter that allows the ROSA robot to be used in conjunction with the NICO BrainPath tube for lesion resection.

METHODS:
A stainless steel adapter was made based on the specifications of the ROSA pointer instrument. Two 3D printed models were used to undergo a “mock” surgery using the adapter to assess for ease of use and applicability.

RESULTS:
The adapter allowed for adequate accessibility and visualization of the tumors in both mock cases. In addition, the stability of the ROSA robot and the design of the adapter allowed the surgeon to rest their hands on the instrument without jeopardizing its position.

CONCLUSION:
The ROSA adapter allowed for accurate navigation and exposure of these lesions, combining the accuracy and stability of the ROSA robot, with the retraction of the BrainPath tube.
Optimal timing for lithium levels
Authors: Black Kevin J 
Published: July 2022

Reddy and Reddy (2014) discuss the optimal timing for lithium levels in patients taking once-daily extended-release lithium formulations. They argue for blood sampling 24 h after the previous dose rather than the standard 12 h. I interpret the data quite differently. The authors start with the assumption that the clinician wants a trough level. I disagree. What one wants is to be able to compare a patient’s lithium level to the large body of published knowledge about lithium dosing. Almost all of that data comes from standard 12-h blood draws with plain (immediate-release) lithium carbonate or lithium citrate. So, the real question of interest is, with extended-release lithium formulations, at what time point does one draw the lithium level to compare most accurately with a standard 12-h blood draw with plain lithium carbonate? The answer is not obvious because extended-release formulations affect only the absorption and not the excretion of lithium. Their primary benefit is reducing the transient peak lithium serum concentration, not delaying the (already relatively slow) elimination of lithium. Emami and colleagues (2004) provide the needed data. First they show that 90% of the administered dose of a commercial extended-release formulation (Eskalith CR®) is absorbed by 4 h after a dose, and ~100% is absorbed by 8 h (their Figure 2A). Second, they show that at 12 h after a dose, the blood levels for immediate and extended release formulations are essentially identical (their Figure 3). Thus 12 h after the previous dose is the ideal time for drawing blood levels for extended-release lithium tablets.
The Role of International Monetary and Credit Relations in the System of the World Economy and Trends in Their Development in Modern Conditions
Authors: Al'mavadzhe Vahib Karim Musa 
Published: July 2022

The article is devoted to the study of the essence of international monetary and credit relations, determining their place and role in the system of world economic relations based on the study of theoretical approaches to the interpretation of this multi-component term, forms of interaction between the participants in these relations, as well as building a conceptual model for positioning monetary and credit relations in the global economic system.
The article presents the main trends in the development of monetary and credit relations in the world space, including: the transformation of international money circulation, currency globalization, currency polycentrism and regionalization, the universalization of the activity of participants in the loan capital markets and the transformation of traditional forms of credit operations, as well as the reasons that caused such changes. The article analyzes statistical data that clearly demonstrate the ongoing processes in the monetary and credit sphere, which determined the methodological tools of the study.
Performance anxiety related to sexual functioning – the role of sexual identity and minority stress.
Authors: Grabski Bartosz , Kasparek Krzysztof 
Published: July 2022

Aim of the studyThe study aimed to inquire if sexual identity was related to performance anxiety, and if proximal minority stress processes contributed to performance anxiety in gay and bisexual men.Subject or material and methodsThe present study was based on a database obtained from a larger Internet-based research project on the sexuality of Polish men of different sexual identities. The present sample consisted of 3,495 participants, i.e., 1,096 straight, 1,701 gay, and 698 bisexual men. The main outcome measure was performance anxiety which was measured using a single-item question: During the last 12 months has there ever been a period of several months when you felt anxious about your ability to perform sexually? Explanatory variables were demographics, relational and sex life characteristics – measured using a self-designed questionnaire, and minority stress processes – measured using the Sexual Minority Stress Scale.ResultsGay and bisexual identities were related to performance anxiety in bivariate analyses however they lost their significance when other factors were controlled for. Relational status was identified as responsible for this change. Internalised homophobia, and expectations of rejection contributed to performance anxiety in minority men.DiscussionA subset of gay and bisexual men, i.e., men who do not stay in committed relationships, may be particularly prone for developing performance anxiety, which is one of major factors contributing to sexual dysfunctions. Minority stress processes should be included in planning clinical interventions targeting sexual problems in theses populations.ConclusionsGay and bisexual men’s sexual problems need to be addressed in an individualised manner, with inclusion of minority specific processes.
Exploring the psychological impact of the COVID-19 pandemic on PICU consultants, advanced nurse practitioners and trainee doctors
Authors: Christmas Alex , Mackinnon Catriona , Brincat Edgar , Donnelly Peter , Worrall Mark 
Published: July 2022

Background: Paediatric intensive care unit (PICU) staff members are at risk of burnout, stress, and fatigue. The COVID-19 pandemic has affected how we live and work; we postulate this increases the risk of stress-related disorders. Aims: To explore the impact of the COVID-19 pandemic on the wellbeing of PICU clinicians. Methods: An anonymised, single-centre survey was sent to clinicians, comprising four sections: burnout, work-related stress, work-related fatigue, and work-life balance. Two free-text questions explored perceptions of work-life balance and measures to improve wellbeing. Results: 55.6% of respondents returned scores suggesting high burnout risk. 55.6% had answers suggesting work-related stress. 82.4% reported work-related fatigue. 55.5% felt that work-life balance had not improved during the pandemic. Conclusions: The proportion of staff at risk of burnout in this study is higher than that reported in pre-pandemic studies. Perceived work-life balance has been negatively impacted, and high levels of work-related stress and fatigue were identified.
Broadband 1T-polytype tantalum disulfide saturable absorber for solid-state bulk lasers
Authors: Wang Mengxia , Qiu Hailong , Yang Tianwen , Wang Zhengping , Zhao Chuanrui , Zhao Yuanan , Yu Ting , Jiang Yuyao , Chen Meiling , Lian Yafei , Zhang Ge , Liu Hongjun , Hu Zhanggui , Shao Jianda 
Published: July 2022

1T-polytype tantalum disulfide (

1
T-TaS

2

), an emerging strongly correlated material, features a narrow bandgap of 0.2 eV, bridging the gap between zero-bandgap graphene and large-bandgap 2D nonlinear optical (NLO) materials. Combined with its intense light absorption, high carrier concentration, and high mobility,

1
T-TaS

2

shows considerable potential for applications in broadband optoelectronic devices. However, its NLO characteristics and related applications have rarely been explored. Here,

1
T-TaS

2

nanosheets are prepared by chemical vapor deposition. The ultrafast carrier dynamics in the 400–1100 nm range and broadband NLO performance in the 515–2500 nm range are systematically studied using femtosecond lasers. An obvious saturable absorption phenomenon is observed in the visible to IR range. The nonlinear absorption coefficient is measured to be

−
22.60
±
0.52

cm

MW

−
1

under 1030 nm, which is larger than that of other typical 2D saturable absorber (SA) materials (graphene, black phosphorus, and

MoS

2

) under similar experimental conditions. Based on these findings, using

1
T-TaS

2

as a new SA, passively Q-switched laser operations are successfully performed at 1.06, 1.34, and 1.94 μm. The results highlight the promise of

1
T-TaS

2

for broadband optical modulators and provide a potential candidate material system for mid-IR nonlinear optical applications.
Comprehensive evaluation of patterns of hypoglycemia unawareness (HUA) and glycemic variability (GV) in patients with fibrocalculous pancreatic diabetes (FCPD): A cross-sectional study from South India
Authors: Dasgupta Riddhi , Jebasingh Felix K. , Anoop Shajith , Seenivasan Santhya , Kurian Mathews Edatharayil , Christina Flory , Varghese Gracy , Christudoss Pamela , Lijesh K. U. , David Deepu , Chowdhury Sudipta Dhar , Paul Thomas V. , Thomas Nihal 
Published: July 2022

Objectives
Hypoglycemia unawareness (HUA) in patients with FCPD is common with an unclear etiology. We evaluated the prevalence, characteristics of HUA, glycemic variability (GV), its possible association with pancreatic glucagon secretion & cardiac autonomic function in patients with FCPD.

Methods
A two-week ambulatory glucose profile (AGP) and cardiac autonomic function test was done in patients with FCPD (n = 60), and categorized into UNAWARE (n = 44) and AWARE (n = 16) groups based on the Hypoglycemia Unawareness Index (HUI) score. Glycaemic variability was assessed from the AGP data using Easy GV 9.0.2 software. A subset of patients from both the groups (n = 11) underwent a mixed-meal challenge test and were compared with healthy individuals (controls; n = 11).

Results
HUA was evidenced in 73% (44/60) of patients with FCPD. Significant hypoglycemia, nocturnal hypoglycemia, duration of hypoglycemia and poor cardiac autonomic functions (p = 0.01) were prominent in the UNAWARE group. The overall GV was greater in the UNAWARE group. In the UNAWARE group, significantly reduced fasting and post prandial glucagon levels negatively correlated with HUI (r = -0.74, p < 0.05) and GV-hypoglycemia indices (p < 0.05) In contrast, significantly higher post prandial glucagon levels in the AWARE group positively correlated with post prandial hyperglycemia (r = 0.61, p < 0.05).

Conclusion
Heterogeneity in patterns of glucagon secretion were significantly associated with HUA and GV. Reduced glucagon levels contribute to greater risks of HUA, nocturnal hypoglycemia and greater GV, while hyperglucagonemia predisposes to postprandial hyperglycemia and hypoglycemia awareness in patients with FCPD.
The Effect of Multiple Inteligence (MI) Towards The Character of Seventh Grade Students of IPA Madrasah Mu'allimin Muhammadiyah Yogyakarta
Authors: Azis Taufik Burhanudin , Anwar Syamsul , Bashori Khoiruddin 
Published: July 2022

The purpose of this research is to analyze the role of multiple intelligence toward solemn pray (sholat khusyuk) of seventh grade student of IPA of Madrasah Mu’alimin Muhammadiyah Yogyakarta. The research was done to contribute in theory development especially related to Islamic Psychology. It is expected to give the real contribution in increasing the solemn practice pray, especially in Madrasah Mu’alimin Muhammadiyah Yogyakarta. Eighty five students were used as sample in this research. The data were analyzed by multiple regression using SPSS program 19.00 version. The results of this research were: 1. The nine independent variables (linguistic intelligence, math logic, musical, kinesthetic, special-visual, interpersonal, intrapersonal, naturalistic, and existential) have roletoward dependent variable (solemn pray) and the trend was positively significant. 2. The nine independent variables give contribution toward dependent variable 95,6%. 3. The independent variable that have dominant role is existencial variable namely 92,3% toward dependent variable. 4. The eight independent variable (linguistic intelligence, math logic, musical, kinesthetic, special-visual, interpersonal, intrapersonal, naturalistic) do not give significant contribution toward dependent variable.
An insight on Vietnamese bio-waste materials as activated carbon precursors for multiple applications in environmental protection
Authors: Ngo Thi Cam Quyen , Tan Lam Van , Thao Nguyen Phuong , Tran Thi Kim Ngan , Hoang Ngoc Bich 
Published: July 2022

AbstractVietnam is known as an agricultural country with a variety of agricultural crops. In addition to agricultural by-products, bio-waste is the by-product from livestock waste, forestry, industry, and daily life. They affect the soil, water, and air environment by self-degradation processes in the environment. Therefore, researchers have come up with ideas for the usage of the by-products to decrease the amount of waste and minimize the environmental effects. In Vietnam, the by-products were used by researchers to produce bio-ethanol, fertilizers, composites, and activated carbon (AC). AC is one of the materials used to rapidly reduce the number of agricultural by-products by researchers. The synthesis process is optimized for the highest yield, while the physicochemical properties are also clearly analyzed through the X-ray diffraction, Fourier transform infrared, and Bacterial endotoxin testing assays. The average recorded specific surface area was about 300 m2 g−1. The functional groups and surface structure showed that the material has an amorphous structure with –OH, –CH, –CC, –C═C, –C═O groups. The AC from agricultural waste had been studied and applied to treat pollutants present in water.
Characterization of the elastic modulus of ceramic–metal composites with physical and mechanical properties by ultrasonic technique
Authors: Erol Ayhan , Bilici Vildan Özkan , Yönetken Ahmet 
Published: July 2022

Abstract
The scope of this study, that is, the effect of the elastic modulus obtained by ultrasonic method on the physical and mechanical properties of tungsten carbide (WC)-based ceramic–metal composites, which have Ni and Co metallic binder composition produced by powder metallurgy and represented by high strength and hardness criteria, was investigated. In order to obtain composite samples in the study, it was sintered in a microwave furnace at different temperatures to combine the powder particles prepared at the rate of 60% Ni, 20% Co, and 20% WC by weight. Then, the velocities and longitudinal attenuation values of longitudinal and shear ultrasonic waves along the composite sample were measured using the ultrasonic pulse-echo method. The elastic modulus of the composites was determined using ultrasonic velocities and sample density. Hardness testing, scanning electron microscopy (SEM), and X-ray diffraction (XRD) analyses were also performed. The results show that the elastic modulus increases with the increase in sintering temperature and ultrasonic wave speeds, but decreases with the longitudinal attenuation value, considering the SEM images and XRD analysis. There is also a linear relationship between elastic modulus and stiffness.