bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of acute kidney disease on the clinical outcomes of patients who received cisplatin, carboplatin, and oxaliplatin
Authors: Fernandes Alexandre Ricardo Da Silva , de Brito Germana Alves , Baptista Aline Lourenço , Andrade Luis André Silvestre , Imanishe Marina Harume , Pereira Benedito Jorge 
Published: January 2022

AbstractBackground and AimsCisplatin (CDDP) is used as the first line of treatment for some tumors, but its use may be restricted due to its nephrotoxicity. Carboplatin (CARBO) and oxaliplatin (OXA) are less nephrotoxic alternatives to CDDP. This study has the objective to determine the incidence of acute kidney disease after chemotherapy with CDDP, CARBO, or OXA.MethodsA clinical study of a retrospective cohort of patients who underwent treatment with CDDP, CARBO, or OXA from January‐December 2016. Acute kidney Disease (AKD) was defined as elevated serum creatinine (sCR) levels before and up to 3 months after chemotherapy. Morbidities, type of tumor, and treatment data were recorded.ResultsA total of 212 patients aged 55.5 ± 14.0 years were evaluated. Among the comorbidities, 30% had arterial hypertension (AH) and 11% had diabetes, and 18% were treated with CDDP, 41% with CARBO, and 41% with OXA. There was no difference in sCR levels before and after chemotherapy regardless of the chemotherapy used. The prevalence of eGFRs <60 mL/min after chemotherapy was higher in patients with AH and cardiovascular disease (CVD). The incidence of post‐chemotherapy AKD was 7.0% (n = 13) and the mortality rate was 38.2%. Survival was lower in patients with AKD (P = .012).ConclusionsThere was a low incidence of AKD among the patients regardless of the chemotherapy used, but the patients with AKD had shorter survival. In addition, the reduction in eGFR after chemotherapy was greater in patients with AH and CVD.
Prevalence of non‐steroidal anti‐inflammatory drugs (NSAIDs) use in patients with hypertensive crisis
Authors: Jahangiri Soodeh , Mousavi Seyed Hamidreza , Hatamnejad Mohammad Reza , Salimi Maryam , Bazrafshan Hamed 
Published: January 2022

AbstractBackgoundOne of the known risk factors for hypertensive crisis (HTN‐C) is non‐steroidal anti‐inflammatory drugs (NSAIDs) which their adverse effects can lead to end‐organ damage such as gastrointestinal and cardiovascular issues.AimsData on the correlation between NSAIDs and HTN‐C are limited. In this study, we determined the prevalence of NSAID use among patients with HTN‐C.Materials & MethodsThis cross‐sectional study was conducted among patients primarily diagnosed with HTN‐C referred to Alzahra hospital, Shiraz, Iran from April 2015 to April 2020. Demographic data, as well as information regarding the past medical and drug history and laboratory findings, were gathered retrospectively. The history of NSAID use was also asked specifically. The collected data were analyzed by SPSS and the P‐value less than .05 was considered significant.ResultsA total of 257 patients with a mean age of 59.73 were enrolled in the study. Among them 62.6% were female and 137 patients (53.33%) used NSAIDs. Of all the patients 197 (76.7%), 71 (27.6%), and 46 (17.9%) suffered from concomitant hypertension (HTN), diabetes mellitus (DM), and ischemic heart disease (IHD) respectively. A significant relation was found between having each of the comorbidities and NSAIDs use among HTN‐C patients (P‐value <.0001). NSAIDs use was also significantly higher in older age (P‐value <.0001) and female gender (P‐value <.02). A high rate of NSAID use was seen among HTN‐C patients with a positive significant correlation to concomitant diseases, older age, and female gender.ConclusionThe Results of our study indicate that NSAIDs are frequently used among those with HTN‐C and considering the adverse effects of these medication our results further highlight the importance of monitoring and limiting NSAID use.
Kejimkujik calibrated catchments: A benchmark dataset for long‐term impacts of terrestrial and freshwater acidification
Authors: Sterling Shannon , Clair Thomas A. , Rotteveel Lobke , O'Driscoll Nelson , Houle Daniel , Halfyard Edmund , Keys Kevin 
Published: January 2022

AbstractDelays in forest recovery from terrestrial acidification combined with climate change are leading Acadian Forest ecosystems into new territory. The Kejimkujik Calibrated Catchments (KCC) Study Program was established in and adjacent to Kejimkujik National Park and Historic Site (KNP) in Southwest Nova Scotia (SWNS), Canada, in the late 1970s to study the impacts of acid precipitation on pristine and vulnerable ecosystems. The KCC now have one of the longest continuously monitored water chemistry records in North America, with data collection beginning in 1980. Its infrastructure includes three gauged streams with regular water chemistry sampling, 12 forest inventory plots, and an atmospheric deposition monitoring station. Recently, LiDAR data coverage was acquired for the study basins. Data collected at the KCC form part of the lake monitoring program of Environment and Climate Change Canada used in acidification, climate change, and mercury studies. Important characteristics of the KCC watersheds are their high sensitivity to acid deposition, high and increasing dissolved organic carbon (DOC) levels and lowland topography causing extensive wetlands. The KCC are also emerging as an important location for the study and protection of terrestrial and aquatic species‐at‐risk.
Some considerations for social cognition assessment in children
Authors: Pineda‐Alhucema Wilmar , Jiménez‐Figueroa Giomar 
Published: January 2022

AbstractSocial cognition is a very important group of neurocognitive processes involved especially in social functioning; currently, the amount of research on this topic is increasing and suggests some considerations about its assessment, particularly in the child population. This article presents some of these considerations focussed on the theoretical models, the type of instrument and some suggestions for the assessment processes. Specifically, four considerations are proposed: to be clear about the purpose of the assessment, to identify the domains of social cognition and the instruments to assess them, to consider the approach to the assessment and to analyse the role of the cultural and social context, all these keeping in mind the children's benefit.
Insect allies—Assessment of a viral approach to plant genome editing
Authors: Pfeifer Kevin , Frieß Johannes L. , Giese Bernd 
Published: January 2022

Abstract
The Insect Allies program of the Defense Advanced Research Projects Agency has already sparked scientific debate concerning technology assessment-related issues, among which the most prevalent is that of dual use. Apart from the issues concerning peaceful applications, the technology also provides the blueprint for a potential bioweapon. However, the combination of a virus-induced genetic modification of crop plants in the field using genetically modified insect vectors poses a greater risk than the hitherto existing use of genetically modified organisms. The technology's great depth of intervention allows a number of sources for hazard and a tendency towards high exposure, but it is also encumbered with notable deficits in knowledge. These issues call for a thorough technology assessment. This article aims to provide an initial characterization from a technology assessment perspective, focusing on potential sources of risk for this novel invasive environmental biotechnology at an early stage of research and development. Integr Environ Assess Manag 2022;18:1488–1499. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
KEY POINTS
In comparison to the hitherto existing use of genetically modified organisms, the high depth of intervention of the Horizontal Environmental Genetic Alteration Agents (HEGAA) enables a number of sources for hazard and a tendency towards high exposure. At the current stage of development, the most critical aspect is the compromised reliability of the HEGAA approach, mainly due to its complex design with three different species. Although some alternative approaches are advantageous, it remains an open question whether modified HEGAA can become a manageable technology for rapid and large-scale interventions for peaceful applications with acceptable risk potential.
Breviarium de Motu Simulato Ad Atomos Pertinenti
Authors: Parrinello Michele 
Published: January 2022

AbstractIn this paper I will present a personal recollection of the development of molecular‐dynamics‐based atomistic simulations in the last forty years. The paper is not meant as a historical account but rather a personal and certainly biased view of the ideas that have underpinned the author's research, allowing ever more complex systems to be studied in an ever more realistic way.
Automatic diagnosis of pneumonia using backward elimination method based SVM and its hardware implementation
Authors: Bodasingi Nalini , Balaji Narayanam , Jammu Bhaskara Rao 
Published: January 2022

AbstractIn this paper, an efficient automatic diagnosis system for pneumonia classification is developed using extracted textural features obtained from appropriate wavelet transformation. For feature extraction and analysis in the classification of pneumonia, different wavelet families such as Db3.3, Rbio3.3, Rbio3.5, and Rbio 3.7 are explored. The optimum feature extraction for distinguishing pneumonia infected lungs from normal lungs comes from combining the Db3.3 and Rbio3.7 wavelet families. The features extracted from Db3.3 and Rbio3.7 wavelets are analyzed by feeding to different supervised learning classifiers. It is observed that SVM with RBF kernel is attaining maximum accuracy of 97.5% within the classification. The RBF kernel, on the other hand, is hampered by its lengthy testing computation time. This paper introduces a novel backward elimination based SVM (BESVM) in order to reduce computation time. The suggested method's experimental findings demonstrate the trade‐off between classification speed and performance. This was also noticed when targeting a real‐time hardware software codesign FPGA environment. The amount of support vectors is optimized using the BESVM technique, resulting in a 30% reduction in resource utilization and a 590 ns delay while maintaining accuracy. In terms of area, latency, and hardware efficiency, the suggested BESVM‐based hardware design demonstrates its efficacy.
Qualimetry Essentials Applied to Embedded Software Development
Authors: Argotti Yann , Baron Claude , Esteban Phillipe 
Published: January 2022

ABSTRACTWith the initial goal of filling gaps in the definition, assessment, control, and prediction of automotive embedded software quality, including standards and regulatory compliance constraints, a three‐year research study was conducted. The multiple contributions of the study to theoretical and applied qualimetry have helped to define a theoretical framework for quality control and monitoring of engineering and product development processes. Then, demonstrating the practicality of this solution, this study was applied on a real example from the automotive industry. This framework initially developed in the scope of embedded software is also applicable to systems and embedded systems, and makes these contributions have an impact on all industrial sectors.
Simulation System Design Methodology in Extended Enterprise Context
Authors: Leroux‐Beaudout Renan , Bruel Jean‐Michel , Ober Ileana , Pantel Marc 
Published: January 2022

ABSTRACTThe use of Model‐Based Systems Engineering and early Verification and Validation through simulations offers an effective way to manage the complexity of real‐world industrial development projects. However, the modeling and simulation activities are often conducted in parallel, based on a common core of requirements. This can lead to a product model that does not conform to the simulation model, and vice versa, due to potential misinterpretation of requirements. To fill this gap and meet the objective of the simulation conformed to the model, we propose a new approach that considers communication between stakeholders of the Extended Enterprise and also between the simulations platforms.
Trust in data‐requesting organizations—A quantitative analysis on cultural antecedents and individual‐level perceptions
Authors: Jenkner Clara Sophie , Ravi Nirmal , Gabel Marie , Vogt Jacqueline‐Charlene 
Published: January 2022

AbstractInteractions in situations involving the disclosure of personal information require trust‐based relationships. However, trust manifests in different ways, depending on the cultural and contextual environment. An in‐depth understanding of how culture influences trust is therefore of considerable importance to managing situations that require the disclosure of sensitive health information, both from an academic and practical perspective. Drawing on the Model of National Culture and the Development of Trust, our study investigates culture as a determinant of trust in data‐requesting organizations. We link the model's three cultural dimensions (relation to self, risk, and authority) with Hofstede's study cultural dimensions and the privacy calculus (Laufer and Wolfe's study). To test our hypotheses, we analyze survey data collected in Nigeria, in cooperation with a non‐governmental organization working on data‐driven healthcare solutions. Our results confirm an influence of culture on trust in data‐requesting organizations which is, however, dependent on the cultural dimension. In addition, we show that perceived benefits increase trust significantly and provide a theoretical starting point for extending the Model of National Culture and the Development of Trust by the dimension relation to benefit.
A comprehensive profiling of soluble immune checkpoints from the sera of patients with non‐small cell lung cancer
Authors: Peng Ying , Zhang Chen , Rui Zhilian , Tang Weiming , Xu Yan , Tao Xiaoxin , Zhao Qi , Tong Xin 
Published: January 2022

AbstractBackgroundImmunotherapy was widely used for the treatment of non‐small cell lung cancer (NSCLC). However, whether inhibition of immune checkpoints individually or simultaneously could improve the therapeutic efficacy of NSCLC remains to be investigated. Here, we explored the aberrant levels of several checkpoints and evaluated their potential diagnostic values for NSCLC.MethodsSerum samples of 89 NSCLC patients and 57 healthy donors were collected from Nanjing Drum Tower Hospital between November 2019 and July 2020. Fourteen human immune checkpoints were quantified by Procarta‐Plex Human Immuno‐Oncology Checkpoint Panel.ResultsThe expression levels of sTIM‐3, sCD137, sCD27, sLAG‐3, sIDO, sPD‐L2, sCD152, sCD80, and sPD‐1 were all significantly increased in serum of NSCLC patients. Especially, sLAG‐3 was significantly elevated in serum of NSCLC patients at early‐stage (stages I and II), TIM‐3, CD137, and CD27 were significantly higher in the advanced NSCLC patients (stages III and IV) than in the early‐stage groups. Receiver operating characteristics (ROC) results showed that except for PD‐1, all the other immune checkpoint proteins had potential diagnostic values for NSCLC. sTIM‐3 had the highest diagnostic accuracy, followed by sLAG‐3. Combining sTIM‐3, sLAG‐3, and sCD137 could increase the accuracy to a higher level. Moreover, sCD27 was correlated with NSCLC cancer type, age, sex, and disease stage, while sCD137 was correlated with age and disease stage. sTIM‐3 and sIDO were correlated with stage and age, respectively.ConclusionsTIM‐3 and LAG‐3 were independent biomarkers for the early diagnosis of NSCLC. The combination of TIM‐3, LAG‐3, and CD137 could increase the diagnostic accuracy.
Eikenella corrodens infections in human: Reports of six cases and review of literatures
Authors: Li Li , Shi Yu‐bo , Weng Xing‐bei 
Published: January 2022

AbstractPurposeTo investigate clinical characteristics of six cases of Eikenella corrodens infection in Ningbo First Hospital in China in recent 2 years.MethodsWe retrospectively analyze medical records of six cases of E. corrodens infection in Ningbo First Hospital from 2020 to 2021. And we describe the gender, age, clinical manifestations, antimicrobial administration, and treatment of the six patients.ResultsFive of the patients had deep infection and they were treated with surgical drainage or abscess resection plus antimicrobial administration. After treatment, five patients were discharged and recovered well, and another patient was transferred to another hospital for further treatment. All the six cases were in line with the reports on the clinical characteristics of patients infected with E. corrodens at home and abroad before 2021.ConclusionEikenella corrodens is a part of the normal flora of human oropharynx, but it can migrate to other parts of the human body to cause severe invasive disease in humans. Although it is susceptible to most antimicrobials, it needs debridement in the treatment of deep infection.
Adolescent cannabis use and later development of schizophrenia: An updated systematic review of longitudinal studies
Authors: Godin Shea‐Lee , Shehata Sherif 
Published: January 2022

AbstractBackgroundThe study aimed to review recent literature not included in previous reviews and ascertain the correlation between early marijuana use among adolescents, between 12 and 18 years of age, and the development of schizophrenia in early adulthood. A further aim was to determine if the frequency of use of marijuana demonstrated any significant effect on the risk of developing schizophrenia in early adulthood.MethodsFive hundred and ninety‐one studies were examined; six longitudinal cohort studies were analyzed using a series of nonparametric tests and meta‐analysis.ResultsNonparametric tests, Friedman tests, and Wilcoxon signed tests showed a highly statistically significant difference in odds ratios for schizophrenia between both high‐ and low‐cannabis users and no‐cannabis users.ConclusionBoth high‐ and low‐frequency marijuana usage were associated with a significantly increased risk of schizophrenia. The frequency of use among high‐ and low‐frequency users is similar in both, demonstrating statistically significant increased risk in developing schizophrenia.
The roles of sex and gender in child and adolescent mental health
Authors: Martin Joanna , Hadwin Julie A. 
Published: January 2022

AbstractNeurodevelopmental and mental health disorders are common in children and young people, and frequently continue to be impairing into adulthood. Biological sex and gender identity are important factors in the likelihood of the development, referral and diagnosis of these disorders, as well as sources of clinical heterogeneity. In this editorial, we highlight that the aetiology of neurodevelopmental and mental health disorders in young people is complex and multi‐faceted. Emerging evidence has implicated sex and gender as playing an important role in understanding the onset and course of psychopathology in childhood and adolescence. Here, we underline the significance of continuing to actively study the roles of sex and gender in the context of outlining potential future research directions and understanding how best to support children and young people.
Recent progress and perspectives on atomic‐layer‐deposited semiconducting oxides for transistor applications
Authors: Cho Min Hoe , Choi Cheol Hee , Jeong Jae Kyeong 
Published: January 2022

AbstractThis paper reviews recent developments in the fabrication of high‐performance n‐channel metal‐oxide thin‐film transistors (TFTs) through atomic‐layer deposition (ALD), which are now attracting attention due to their potential for use in augmented and virtual reality, ultra‐high‐definition organic light‐emitting diodes, and flexible electronics. Recent trends in research on TFT backplanes for display applications are provided in the introduction. In the main section, ALD‐derived n‐type oxides serving as active layers are classified into binary, ternary, and quaternary systems, and recent developments and critical issues in n‐channel oxide TFTs are described. The performance of n‐channel oxide TFTs can be boosted through advanced architectures, including stacked heterojunction channels using two‐dimensional electron gases, and the introduction of high‐k dielectric such as ALD‐derived hafnium oxide, which is highlighted in this review. Finally, progress in p‐channel ALD‐derived oxide TFTs is briefly addressed with respect to complementary metal–oxide‐semiconductor applications.
Investigation of the effects of surface roughness on stress distribution and moment carrying capacity at shrink‐fitted joints
Authors: Saraç İ. 
Published: January 2022

AbstractAn important design parameter in shrink‐fitted joints is the average surface roughness values of the shaft and hub. During assembly, the surface roughness is crushed and the theoretical tightness value decreases between the shaft and the hub. The decrease in the tightness value negatively affects the joint performance. In this study, six models with six different surface roughnesses were created using ANSYS finite element analysis program. Then, the effects of surface roughness on the stress distribution and moment bearing capacity of the shaft‐hub joints are examined numerically and analytically. Lame equations were used in the analytical study. As a result of the study, it was determined that the surface roughness values significantly affect the stress distribution and moment bearing capacity in the shaft‐hub joints
Corrosion behavior of zinc and copper coated structural steels in soil environments
Authors: Palsson N. , Khamsuk P. , Sorachot S. , Wongpinkaew K. , Thaiwirot W. , Phaebua K. , Klomjit P. 
Published: January 2022

AbstractCorrosion behavior of structural carbon steels grade SS400 coated with copper and zinc exposed to soil sample extracted from the central part of Thailand is studied using weight loss analyses and electrochemical methods, including open circuit potential monitoring for 3600 seconds, electrochemical impedance spectroscopic analyses and potentiodynamic polarization measurements. Bare carbon steels are also examined as a reference. Open circuit potential and polarization resistance of all samples are measured on (1, 2, 3, 4, 7, 10, 15, 30, 45, 60, 77 and 91) days of exposure. Corrosion potential is monitored only on the first and last days. After 91 days, corrosion rate in millimeter per year is calculated from weight loss and corrosion product is characterized. Effects of coating material, thickness and process on corrosion resistance of carbon steel subjected to soil environment are reported and discussed.