bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous placement of short implants (≤ 8 mm) versus standard length implants (≥ 10 mm) after sinus floor elevation in atrophic posterior maxillae: a systematic review and meta-analysis
Authors: Tang Chenxi , Du Qianhui , Luo Jiaying , Peng Lin 
Published: October 2022

Abstract
Purpose
The objective of this meta-analysis was to compare the clinical outcomes of using short implants (≤ 8 mm) inserted with osteotome sinus floor elevation (OSFE) and standard implants (≥ 10 mm) inserted with sinus floor elevation (SFE) in atrophic posterior maxillae with insufficient residual bone height (RBH).

Methods
An electronic search was performed on PubMed, EMBASE, and the Cochrane Library from 1994 to July 2022, in combination with a manual search of references in relevant articles. Randomized controlled trials (RCTs) that compared the clinical results between short and standard implant placement with SFE were included. The primary outcomes were implant survival rate and marginal bone loss (MBL); the secondary outcome was complication rate.

Results
Three RCTs were included, totaling 138 short and 156 standard implants. The results of the meta-analysis showed no significant differences between the short and standard implant groups in survival rate (RR = 1.02, 95% CI   0.96–1.08, p = 0.570), MBL (MD = − 0.13, 95% CI   − 0.32 to 0.07, p = 0.190) and complication rate (intra-surgical complication: RR = 1.14, 95% CI   0.46–2.83, p = 0.770; post-operative complication: RR = 1.34, 95% CI   0.71–2.55, p = 0.370).

Conclusions
Using short implants (≤ 8 mm) combined with OSFE might be an alternative to standard implants (≥ 10 mm) with SFE when the RBH of the posterior maxilla is insufficient. Based on a short-term clinical observation, short implants with OSFE show good results in terms of survival rate, MBL, and complication incidence.

Graphical Abstract
High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain
Authors: Yang Huan , Datta-Chaudhuri Timir , George Sam J. , Haider Bilal , Wong Jason , Hepler Tyler D. , Andersson Ulf , Brines Michael , Tracey Kevin J. , Chavan Sangeeta S. 
Published: October 2022

Abstract
Background
Neuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation may present an opportunity for developing novel pain therapies. In preclinical models of neuroinflammatory pain, calcitonin gene-related peptide (CGRP), substance P and high mobility group box 1 protein (HMGB1) are molecules synthesized and released by sensory neurons which activate inflammation and pain. High-frequency electrical nerve stimulation (HFES) has achieved clinical success as an analgesic modality, but the underlying mechanism is unknown. Here, we reasoned that HFES inhibits neuroinflammatory mediator release by sensory neurons to reduce pain.

Methods
Utilizing in vitro and in vivo assays, we assessed the modulating effects of HFES on neuroinflammatory mediator release by activated sensory neurons. Dorsal root ganglia (DRG) neurons harvested from wildtype or transgenic mice expressing channelrhodopsin-2 (ChR2) were cultured on micro-electrode arrays, and effect of HFES on optogenetic- or capsaicin-induced neuroinflammatory mediator release was determined. Additionally, the effects of HFES on local neuroinflammatory mediator release and hyperalgesia was assessed in vivo using optogenetic paw stimulation and the neuropathic pain model of chronic constriction injury (CCI) of the sciatic nerve.

Results
Light- or capsaicin-evoked neuroinflammatory mediator release from cultured transgenic DRG sensory neurons was significantly reduced by concurrent HFES (10 kHz). In agreement with these findings, elevated levels of neuroinflammatory mediators were detected in the affected paw following optogenetic stimulation or CCI and were significantly attenuated using HFES (20.6 kHz for 10 min) delivered once daily for 3 days.

Conclusion
These studies reveal a previously unidentified mechanism for the pain-modulating effect of HFES in the setting of acute and chronic nerve injury. The results support the mechanistic insight that HFES may reset sensory neurons into a less pro-inflammatory state via inhibiting the release of neuroinflammatory mediators resulting in reduced inflammation and pain.
Integrated interventions and supporting activities to increase uptake of multiple cancer screenings: conceptual framework, determinants of implementation success, measurement challenges, and research priorities
Authors: Subramanian Sujha , Tangka Florence K. L. , Hoover Sonja , DeGroff Amy 
Published: October 2022

Abstract
Background
Screening for colorectal, breast, and cervical cancer has been shown to reduce mortality; however, not all men and women are screened in the USA. Further, there are disparities in screening uptake by people from racial and ethnic minority groups, people with low income, people who lack health insurance, and those who lack access to care. The Centers for Disease Control and Prevention funds two programs—the Colorectal Cancer Control Program and the National Breast and Cervical Cancer Early Detection Program—to help increase cancer screenings among groups that have been economically and socially marginalized. The goal of this manuscript is to describe how programs and their partners integrate evidence-based interventions (e.g., patient reminders) and supporting activities (e.g., practice facilitation to optimize electronic medical records) across colorectal, breast, and cervical cancer screenings, and we suggest research areas based on implementation science.

Methods
We conducted an exploratory assessment using qualitative and quantitative data to describe implementation of integrated interventions and supporting activities for cancer screening. We conducted 10 site visits and follow-up telephone interviews with health systems and their partners to inform the integration processes. We developed a conceptual model to describe the integration processes and reviewed screening recommendations of the United States Preventive Services Task Force to illustrate challenges in integration. To identify factors important in program implementation, we asked program implementers to rank domains and constructs of the Consolidated Framework for Implementation Research.

Results
Health systems integrated interventions for all screenings across single and multiple levels. Although potentially efficient, there were challenges due to differing eligibility of screenings by age, gender, frequency, and location of services. Program implementers ranked complexity, cost, implementation climate, and engagement of appropriate staff in implementation among the most important factors to success.

Conclusion
Integrating interventions and supporting activities to increase uptake of cancer screenings could be an effective and efficient approach, but we currently do not have the evidence to recommend widescale adoption. Detailed multilevel measures related to process, screening, and implementation outcomes, and cost are required to evaluate integrated programs. Systematic studies can help to ascertain the benefits of integrating interventions and supporting activities for multiple cancer screenings, and we suggest research areas that might address current gaps in the literature.
Spin-half bosons with mass dimension three-half: Evading the spin-statistics theorem
Authors: Ahluwalia Dharam Vir , Lee Cheng-Yang 
Published: October 2022

Abstract
By exploiting the freedom in defining the dual of spinors, we report an unexpected theoretical discovery of a quantum field theory of spin-half bosons. It fulfils Dirac's 1969-70 observation that “there must be boson variables connected with electrons”. The theory is local, Lorentz invariant, and has a positive-definite Hamiltonian. We formulate the unitarity-preserving scattering theory to accommodate the new dual and the associated adjoint. A model of Yukawa interaction with spin-half bosons and fermions of equal masses is studied to explicitly show unitarity.
Peptide Receptor Radionuclide Therapy
Authors: Hofland Johannes , Brabander Tessa , Verburg Frederik A , Feelders Richard A , de Herder Wouter W 
Published: October 2022

Abstract
The concept of using a targeting molecule labeled with a diagnostic radionuclide for using positron emission tomography or single photon emission computed tomography imaging with the potential to demonstrate that tumoricidal radiation can be delivered to tumoral sites by administration of the same or a similar targeting molecule labeled with a therapeutic radionuclide termed “theranostics.” Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs (SSAs) is a well-established second/third-line theranostic treatment for somatostatin receptor-positive well-differentiated (neuro-)endocrine neoplasms (NENs). PRRT with 177Lu-DOTATATE was approved by the regulatory authorities in 2017 and 2018 for selected patients with low-grade well-differentiated gastroenteropancreatic (GEP) NENs. It improves progression-free survival as well as quality of life of GEP NEN patients. Favorable symptomatic and biochemical responses using PRRT with 177Lu-DOTATATE have also been reported in patients with functioning metastatic GEP NENs like metastatic insulinomas, Verner Morrison syndromes (VIPomas), glucagonomas, and gastrinomas and patients with carcinoid syndrome. This therapy might also become a valuable therapeutic option for inoperable low-grade bronchopulmonary NENs, inoperable or progressive pheochromocytomas and paragangliomas, and medullary thyroid carcinomas. First-line PRRT with 177Lu-DOTATATE and combinations of this therapy with cytotoxic drugs are currently under investigation. New radiolabeled somatostatin receptor ligands include SSAs coupled with alpha radiation emitting radionuclides and somatostatin receptor antagonists coupled with radionuclides.
Big Game, Small World
Authors: Wolff Alexander 
Published: October 2022

During the late 1990s, eminent basketball journalist Alexander Wolff traveled the globe to determine how a game invented by a Canadian clergyman became an international phenomenon. Big Game, Small World presents Wolff’s dispatches from sixteen countries spread across five continents and multiple US states. In them, he asks: What can the game tell us about the world? And what can the world tell us about the game? Whether traveling to Bhutan to challenge its king to a pickup game, exploring the women’s game in Brazil, or covering the Afrobasket tournament in Luanda, Angola, during a civil war, Wolff shows how basketball has the power to define an individual, a culture, and even a country.
This updated twentieth anniversary edition features a new preface in which Wolff outlines the contemporary rise of athlete-activists while discussing the increasing dominance within the NBA of marquee international players like Luka Dončić and Giannis Antetokounmpo. A loving celebration of basketball, Big Game, Small World is one of the most insightful books ever written about the game.
Development and validation of sonological classification and scoring system for uterine adenomyosis: A pilot study
Authors: Sinha Sudwita , Agarwal Mukta , Bhadani Punam Prasad , Roy Ria , Sinha Upasna 
Published: October 2022

Background: Adenomyosis is a common disorder in women of reproductive age. The gold standard for diagnosis is histopathological examination of hysterectomy specimen. However, only a small percentage of women undergo surgery as treatment is primarily hormonal. Non-invasive methods of diagnosis include transvaginal sonography and magnetic resonance imaging. Patient management in adenomyosis is often based on ultrasonographic diagnosis alone, highlighting the importance of a uniform, reproducible, clinically relevant and validated sonological classification and scoring system. Although a few investigators have proposed classification and scoring system for diagnosis of adenomyosis, none of those have been validated yet. This study aimed to propose and validate a new sonological classification and scoring system for adenomyosis. Methods: This was a prospective observational pilot study. A new sonological classification and scoring system of adenomyosis was proposed based on topography, type, size and extent, which was validated by comparing the sonological reporting with histopathological reporting. The main outcome measures that were measured were rate of agreement (Cohen’s kappa) between the findings of sonologist and pathologist; and diagnostic accuracy of the sonological classification of adenomyosis. Results: This pilot study included 30 women who underwent hysterectomy over a time period of one year with ultrasonographic diagnosis of adenomyosis. The rate of agreement (Cohen’s kappa) between the findings of sonologist and pathologist showed substantial agreement (0.703) for topography and almost perfect agreement for type (0.896), extent (0.892) and size (0.898). Conclusions: Our newly proposed sonological classification and scoring system for adenomyosis is valid and can be used for clinical application in interpersonal communication between clinicians, to prognosticate patients about the disease severity, to assess the candidates for surgical management and in further studies to correlate with symptoms severity and effectiveness of medical therapies.
Rationale for extent of operation choice in rectal cancer
Authors: Nikitenko R. , Kosovan V. , Vorotyntseva K. , Koichev E. 
Published: October 2022

Introduction. Colorectal cancer (CRC) remains relevant occupying one of the leading places in morbidity and mortality among oncological diseases. It reaches 13.5% in the structure of tumor diseases tending to increase.
The aim of the work to improve the choice of surgical treatment management and reduce the number of intraoperative and postoperative complications in rectal cancer patients.
Materials and methods. 184 operated patients with rectal cancer (RC) were divided into 2 groups: 1 group (patients with stage I RC (T1-2N0M0) and 2 group (stage II RC (T3N0M0)) who were carried out intraoperative detection and examination of sentinel lymph nodes. The volume and surgical approach depended on the stage and the presence of metastases (MTS). The average period of postoperative observation was 12–60 months, taking into account early (purulent-septic complications, bleeding, intestinal perforation) and distant (recurrence of rectal cancer) complications.
Results. The patients of the 1 group had no MTS lesions of sentinel lymph nodes, due to this fact the surgical intervention was limited to transanal microsurgery. Among the complications were the following: bleeding – 2.2%; intraoperative perforation of the intestinal wall – 5.6%. No purulent-septic cases, no recurrences of rectal cancer were detected. In group 2, of 94 patients, 36 (38.3%) had MTS detected intraoperatively in sentinel lymph nodes which required a low anterior rectal resection with total mesorectomectomy. Among the complications was bleeding – 6.3%. No intraoperative perforations of the intestinal wall and no purulent-septic complications were detected. Recurrence of rectal cancer was detected in 12 (13.8%) patients.
Conclusions. Performing transanal endoscopic resections in patients with RC I and especially stage II is possible only under the conditions of mandatory intraoperative staining and emergency histological examination of "sentinel" lymph nodes. The extent of surgical intervention is determined on the operating table based on the results of an emergency histological examination. When MTS lesions of the mesorectal "sentinel lymph nodes" are detected, the operation should be continued with mandatory mesorectomectomy.
TiN-GST-TiN all-optical reflection modulator for the 2 µm wave band reaching 85% efficiency
Authors: Bhuiyan Md Asif Hossain , Mitu Shamima Akter , Choudhury Sajid Muhaimin 
Published: October 2022

In this study, we present an all-optical reflection modulator for the
2 µm communication band exploiting a nanogear-array metasurface
and phase-change-material

G
e

2

S
b

2

T
e

5

(GST). The reflectance of the
structure can be manipulated by altering the phase of GST by employing
optical stimuli, and this paper provides details on the optical and
opto-thermal modeling techniques of GST. A numerical investigation
reveals that the metastructure exhibits a conspicuous changeover from

∼

99
%

absorption to very poor interaction
with the operating light depending on the switching states of the GST,
ending up with 85% modulation depth and only 0.58 dB insertion
loss. Due to noticeable differences in optical responses, we can
demonstrate a high extinction ratio of 28 dB and a commendable
figure of merit of 49, so far the best modulation performance in this
wavelength window, to our knowledge. In addition, real-time tracking
of reflectance during phase transition manifests high-speed switching
expending low energy per cycle, of the order of sub-nJ. Hence, given
its overall performance, the device will be a paradigm for optical
modulators for upcoming 2 µm communication technology.
Compact and broadband on-chip silicon polarization beam splitter based on tilted subwavelength grating
Authors: Sun Haoyang , Xu Yin , Dong Yue , Zhang Bo , Ni Yi 
Published: October 2022

Efficient polarization management is a key issue for on-chip silicon photonic integrated circuits. Here, we propose a compact and broadband on-chip silicon polarization beam splitter (PBS) using tilted subwavelength grating (SWG) structure. The key polarization separation region consists of an input tapered SWG, a titled SWG, and two output tapered SWGs at both output ports. The tilted SWG has a strong polarization dependence for the mode coupling, and we have introduced different grating duty cycles, positional offset, and a new, to the best of our knowledge, output mode transition structure to enhance the device performance. Based on these techniques, the key coupling length of the proposed PBS is only 5 µm (total length, 12 µm), together with polarization extinction ratio (ER) 21.2 dB (19.7 dB) and insertion loss 0.21 dB (0.39 dB) for the TE (TM) mode. Moreover, the device working bandwidth can be extended to 311 nm (154 nm) by keeping

E
R

>

15

d
B

(

E
R

>

18

d
B

), satisfying the on-chip broadband applications. We believe the proposed device could become a good candidate to boost the on-chip polarization management toward compact and broadband directions.
After action review of the response to an outbreak of Lassa fever in Sierra Leone, 2019: Best practices and lessons learnt
Authors: Njuguna Charles , Vandi Mohamed , Liyosi Evans , Githuku Jane , Squire James Sylvester , Njeru Ian , Rufus Ian , Katawera Victoria , Gachari Wilson , Musoke Robert , Amuzu Claudette , Fahnbulleh Mukeh , Bunting-Graden Joseph , Kayita Janet , Bunn James , Talisuna Ambrose , Yoti Zabulon 
Published: October 2022

Background
In November 2019, an outbreak of Lassa Fever occurred among health workers in a non-endemic district in Sierra Leone. The outbreak resulted in five cases, including two that were exported to the Netherlands. The outbreak tested multiple technical capacities in the International Health Regulations (2005) in a real-life setting. As such, an after action review (AAR) was undertaken as recommended by World Health Organization. We report on the findings of the AAR including best practices and lessons learnt.

Methods
A two stage review process was employed. The first stage involved national pillar level reviews for each technical pillar and one review of the district level response. The second stage brought together all pillars, including participants from the national and sub-national level as well as health sector partners. National guidelines were used as references during the deliberations. A standardized template was used to report on the key findings on what happened, what was supposed to happen, what went well and lessons learnt.

Results
This was a hospital associated outbreak that likely occurred due to a breach in infection prevention and control (IPC) practices resulting in three health workers being infected during a surgical operation. There was a delay in detecting the outbreak on time due to low index of suspicion among clinicians. Once detected, the outbreak response contained the outbreak within one incubation period. Areas that worked well included coordination, contact tracing, active case search and ring IPC. Notable gaps included delays in accessing local emergency funding and late distribution of IPC and laboratory supplies.

Conclusions
The incident management system worked optimally to contain this outbreak. The core technical gaps identified in surveillance, IPC and delay in deployment of resources should be addressed through systemic changes that can mitigate future outbreaks.
The impact of patient travel time on disparities in treatment for early stage lung cancer in California
Authors: Obrochta Chelsea A. , Parada Humberto , Murphy James D. , Nara Atsushi , Trinidad Dennis , Araneta Maria Rosario (Happy) , Thompson Caroline A. 
Published: October 2022

Background
Travel time to treatment facilities may impede the receipt of guideline-concordant treatment (GCT) among patients diagnosed with early-stage non-small cell lung cancer (ES-NSCLC). We investigated the relative contribution of travel time in the receipt of GCT among ES-NSCLC patients.

Methods
We included 22,821 ES-NSCLC patients diagnosed in California from 2006–2015. GCT was defined using the 2016 National Comprehensive Cancer Network guidelines, and delayed treatment was defined as treatment initiation >6 versus ≤6 weeks after diagnosis. Mean-centered driving and public transit times were calculated from patients’ residential block group centroid to the treatment facilities. We used logistic regression to estimate risk ratios and 95% confidence intervals (CIs) for the associations between patients’ travel time and receipt of GCT and timely treatment, overall and by race/ethnicity and neighborhood socioeconomic status (nSES).

Results
Overall, a 15-minute increase in travel time was associated with a decreased risk of undertreatment and delayed treatment. Compared to Whites, among Blacks, a 15-minute increase in driving time was associated with a 24% (95%CI = 8%-42%) increased risk of undertreatment, and among Filipinos, a 15-minute increase in public transit time was associated with a 27% (95%CI = 13%-42%) increased risk of delayed treatment. Compared to the highest nSES, among the lowest nSES, 15-minute increases in driving and public transit times were associated with 33% (95%CI = 16%-52%) and 27% (95%CI = 16%-39%) increases in the risk of undertreatment and delayed treatment, respectively.

Conclusion
The benefit of GCT observed with increased travel times may be a ‘Travel Time Paradox,’ and may vary across racial/ethnic and socioeconomic groups.