bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality
Authors: Youssef Mohamed , Moussa Nermine , W. Helmy Maged , Haroun Medhat 
Published: July 2022

AbstractAberrant activation of several signaling pathways has been implicated in prostate cancer (PCa) progression to castrate-resistant prostate cancer (CRPC). Phosphoinositide-3-kinase/Protein Kinase B/mechanistic Target of Rapamycin (PI3K/AKT/mTOR) and Hedgehog/GLI (Hh/GLI) pathways are major participants in progression to CRPC. In this sense, the current work aims to assess the potential antitumor effects resulting from co-targeting the aforementioned pathways in PC3 cells with Dactolisib as a dual PI3K/mTOR inhibitor and GANT61 as a GLI1 antagonist. Three replica of PC3 cells were assigned for four treatment groups; vehicle control, Dactolisib-treated, GANT61-treated, and combination-treated groups. GLI1 gene expression was determined by quantitative real-time PCR while active caspase-3 was determined colorimetrically. P-AKT, p70 ribosomal s6 protein kinase 1 (pS6K1), cyclin D1, vascular endothelial growth factor 1 (VEGF1), and Microtubule-associated proteins 1A/1B light chain 3 (LC3) protein levels were determined by ELISA technique. GLI1 gene expression was down-regulated as a result of Dactolisib, GANT61, and their combination. Additionally, both drugs significantly reduced p-AKT, pS6K1, cyclin D1, and VEGF1 protein levels. Dactolisib elevated LC3 protein levels and GANT61 augmented Dactolisib effect on LC3. Moreover, only Dactolisib/GANT61combination significantly increased active caspase-3 level. To sum up, Dactolisib/GANT61 combination was shown to be promising in PCa treatment. Further in-vitro and in-vivo studies are warranted to support our findings.
Impact of Cell Disintegration Techniques on Curcumin Recovery
Authors: Le-Tan Hoang , Jaeger Henry 
Published: July 2022

Abstract
In recent years, the improvement of curcumin recovery from turmeric by cell and tissue disintegration techniques has been gaining more attention; these emerging techniques were used for a reproducible and robust curcumin extraction process. Additionally, understanding the material characteristics is also needed to choose the optimized technique and appropriate processing parameters. In this review, an outlook about the distribution of different fractions in turmeric rhizomes is reviewed to explain matrix challenges on curcumin extraction. Moreover, the most important part, this review provides a comprehensive summary of the latest studies on ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), enzyme-assisted extraction (EAE), high-pressure-assisted extraction (HPAE), pulsed electric field-assisted extraction (PEFAE), and ohmic heating-assisted extraction (OHAE). Lastly, a detailed discussion about the advantages and disadvantages of emerging techniques will provide an all-inclusive understanding of the food industry’s potential of different available processes.
Microexpressions in digital humans: perceived affect, sincerity, and trustworthiness
Authors: Tastemirova Aliya , Schneider Johannes , Kruse Leona Chandra , Heinzle Simon , Brocke Jan vom 
Published: July 2022

Abstract

Digital agents with human-like characteristics have become ubiquitous in our society and are increasingly relevant in commercial applications. While some of them closely resemble humans in appearance (e.g., digital humans), they still lack many subtle social cues that are important for interacting with humans. Among them are the so-called microexpressions— facial expressions that are short, subtle, and involuntary. We investigate to what extent microexpressions in digital humans influence people's perceptions and decision-making in order to inform the practices of digital human's design. Our two experiments applied four types of microexpressions based on emotion type (happiness and anger) and intensity (normal and extreme). This paper is among the first to design and evaluate microexpressions with different intensity levels in digital humans. In particular, we leverage the possibilities of digitally (re)designing humans and human perception. These possibilities are feasible only in a digital environment, where it is possible to explore various microexpressions beyond real human beings' physical capabilities.
Politik der Befähigung
Authors: Cremer Georg 
Published: July 2022

ZusammenfassungAuf der Grundlage des Befähigungsansatzes diskutiert der Beitrag, wie die soziale Infrastruktur in Deutschland stärker für eine Politik genutzt werden kann, die die Verwirklichungschancen von Menschen erweitert. Dazu gehört, hemmende soziale und persönliche Umwandlungsfaktoren zu verändern; soziale Dienste können dazu einen Beitrag leisten. Ein gezielter kompensatorischer Ressourceneinsatz ist notwendig, um den engen Zusammenhang zwischen der sozialen Herkunft von Kindern und ihrem Bildungserfolg zu lockern; Dies widerspricht jedoch verbreiteten Gerechtigkeitsvorstellungen in der Mittelschicht. Es gibt verfestigte Kooperationsblockaden im deutschen Sozialstaat, die sich aus seiner institutionellen Struktur und den damit verbundenen Zuständigkeitsregeln und Finanzierungslogiken ergeben. Sie erzeugen Präventionsdilemmata und erschweren oder verhindern Hilfen (wie) aus einer Hand. Gegenläufige Ansätze wie das Konzept der Sozialraumorientierung, das einige Ähnlichkeiten mit dem Befähigungsansatz aufweist, werden häufig zu abstrakt und floskelhaft diskutiert, um Wirkung zu entfalten. Auch sind komplexe Fragen der Ordnung der Märkte sozialer Dienstleistungen zu klären. Der Beitrag plädiert für eine Reformpolitik zum Abbau der rechtlichen Kooperationshürden und für einen datenbasierten Dialog über Qualität und Wirkungen sozialer Dienste in lokalen Befähigungspartnerschaften.
Enhanced cathodic activity by tantalum inclusion at B-site of La0.6Sr0.4CO0.4Fe0.6O3 based on structural property tailored via camphor-assisted solid-state reaction
Authors: Xiong Dingyu , Rasaki Sefiu Abolaji , Li Yangpu , Fan Liangdong , Liu Changyong , Chen Zhangwei 
Published: July 2022

AbstractLanthanum strontium cobalt ferrite (LSCF) is an appreciable cathode material for solid oxide fuel cells (SOFCs), and it has been widely investigated, owing to its excellent thermal and chemical stability. However, its poor oxygen reduction reaction (ORR) activity, particularly at a temperature of ⩽ 800 °C, causes setbacks in achieving a peak power density of > 1.0 W·cm−2, limiting its application in the commercialization of SOFCs. To improve the ORR of LSCF, doping strategies have been found useful. Herein, the porous tantalum-doped LSCF materials (La0.6Sr0.4Co0.4Fe0.57Ta0.03O3 (LSCFT-0), La0.6Sr0.4Co0.4Fe0.54Ta0.06O3, and La0.6Sr0.4Co0.4Fe0.5Ta0.1O3) are prepared via camphor-assisted solid-state reaction (CSSR). The LSCFT-0 material exhibits promising ORR with area-specific resistance (ASR) of 1.260, 0.580, 0.260, 0.100, and 0.06 Ω·cm2 at 600, 650, 700, 750, and 800 C, respectively. The performance is about 2 times higher than that of undoped La0.6Sr0.4Co0.4Fe0.6O3 with the ASR of 2.515, 1.191, 0.596, 0.320, and 0.181 Ω·cm2 from the lowest to the highest temperature. Through material characterization, it was found that the incorporated Ta occupied the B-site of the material, leading to the enhancement of the ORR activity. With the use of LSCFT-0 as the cathode material for anode-supported single-cell, the power density of > 1.0 W·cm−2 was obtained at a temperature < 800 °C. The results indicate that the CSSR-derived LSCFT is a promising cathode material for SOFCs.
A multi-objective particle swarm optimization with density and distribution-based competitive mechanism for sensor ontology meta-matching
Authors: Geng Aifeng , Lv Qing 
Published: July 2022

AbstractSensor ontology is a standard conceptual model that describes information of sensor device, which includes the concepts of various sensor modules and the relationships between them. The problem of heterogeneity between sensor ontologies is introduced because different sensor ontology engineers have different ways of describing sensor devices and different structures for the construction of sensor ontologies. Addressing the heterogeneity of sensor ontologies contributes to facilitate the semantic fusion of two sensor ontologies, enabling the sharing and reuse of sensor information. To solve the above problem, an ontology meta-matching method is proposed by this paper to find out the correspondence between entities in distinct sensor ontologies. How to measure the degree of similarity between entities with a set of suitable similarity measures and how to better integrate multiple measures to determine the equivalent entities are the challenges of the ontology meta-matching problem. In this paper, two approximate measurement methods of the quality for ontology matching results are designed, and a multi-objective optimization model for the ontology meta-matching problem is constructed based on these methods. Eventually, a multi-objective particle swarm optimization (MOPSO) algorithm is propounded to dispose of the problem and optimize the quality of ontology meta-matching results, which is named density and distribution-based competitive mechanism multi-objective particle swarm algorithm (D$$^{2}$$

2

CMOPSO). The sophistication of the D$$^{2}$$

2

CMOPSO based sensor ontology meta-matching method is verified through experiments. Comparing with other matching systems and advanced systems of Ontology Alignment Evaluation Initiative (OAEI), the proposed method can improve the quality of matching results more effectively.
Effects of cannabidiol on weight and fasting blood sugar with chronic and subchronic haloperidol administration
Authors: Kajero Jaiyeola Abiola , Seedat Soraya , Ohaeri Jude U. , Akindele Abidemi , Aina Oluwagbemiga 
Published: July 2022

Abstract
Objectives
The duration of administration (e.g., subchronic or chronic) of haloperidol may influence its adverse effects. We studied the effects of duration of administration of haloperidol on body weight and fasting blood sugar (FBS). In addition, we examined whether orally administered cannabidiol (CBD) had any putative mitigating influence on haloperidol-induced body weight changes and FBS elevation.

Methods
Haloperidol (5 mg/kg/day) was administered for 21 days (subchronic administration), via the intraperitoneal (IP) route, or monthly (50 mg/kg monthly) for 3 months (chronic administration), via the intramuscular (IM) route, either alone or before CBD (5 mg/kg/day). Oral CBD (5 mg/kg/day) alone and distilled water alone were administered for 21 days. Weight and FBS were measured before administration of pharmacological agents (distilled water in the control group) and post-administration.

Results
Group differences in average weight across time were significant. Pairwise comparisons showed that mean weight of the subchronic (IP) haloperidol alone group (Group A) and the chronic (IM) haloperidol before CBD group (Group F) increased significantly over time. Post medications, there was a significant increase in mean FBS in the subchronic (IP) haloperidol group compared to the subchronic (IP) haloperidol before CBD group. There was also a significant reduction in mean FBS from the baseline for the control group only.

Conclusion
We demonstrated that the duration of administration of haloperidol influenced weight and FBS in rats, suggesting that metabolic side effects, may be influenced by duration of administration. CBD ameliorated the increase in weight and FBS observed in the subchronic (IP) haloperidol groups.
From type to network: a review of knowledge representation methods in architecture intelligence design
Authors: Li Yihui , Gao Wen , Lin Borong 
Published: July 2022

AbstractWith the rise of the next generation of artificial intelligence driven by knowledge and data, the research on knowledge representation in architecture is also receiving widespread attention from the academia. This paper sorts out the evolution of architectural knowledge representation methods in the history of architecture, and summarizes three progressive representation frameworks of their development with type, pattern and network. By searching these three keywords in the Web of Science Core Collection among 4867 publications from 1990 to 2021, the number of publications in the past 5 years raised more than 50%, which show significant research interest in architecture industry in recent years. Among them, the first two are static declarative knowledge representation methods, while the network-based knowledge representation method also includes procedural knowledge representation methods and provides a way for knowledge association. This means the network representation has more advantage in terms of the logical completeness of knowledge representation, and accounts for 67% of the current research on knowledge representation in architecture. In the context of the rapid development of artificial intelligence, this method can realize the construction of architectural knowledge system and greatly improve the work efficiency of the building industry. On the other hand, in the face of carbon-neutral sustainable development scenarios, using knowledge representation, building performance knowledge and design knowledge could be expressed in a unified manner, and a personalized and efficient workflow for performance-oriented scheme design and optimization would be achieved.
Healthcare expansion in Indonesia and Thailand: a causal mechanism and its implications for welfare regimes
Authors: Yuda Tauchid Komara , Pholpark Aungsumalee 
Published: July 2022

AbstractThis article provides an overview of the scholarship on healthcare reform in democratic middle-income countries through comparative cases from Indonesia and Thailand. This study identifies the reasons why Thailand has achieved universal healthcare faster than Indonesia and analyses the policy outputs towards universalism resulting from unfolding reforms. Taking a closer look at the causal mechanisms underpinning healthcare developments (clientelistic-based mechanism and limited vertical alliance-based mechanism), we discuss how changes in political economy have enhanced the state’s intervention in the healthcare sector while reproducing the fragmented and stratified nature of the system. Based on coverage, generosity and financial risk protection, Thailand has a higher degree of universalism in comparison with Indonesia. The article suggests that the welfare regime now governing healthcare can be conceptualised as a developmental-universalist state, while noting a less-effective model for Indonesia and a more effective model for Thailand.
Improving chemical control of nonnative aquatic plants in run-of-the-river reservoirs
Authors: Wersal Ryan M. , Sartain Bradley T. , Getsinger Kurt D. , Madsen John D. , Skogerboe John G. , Nawrocki Justin J. , Richardson Rob J. , Sternberg Morgan R. 
Published: July 2022

AbstractCurrent dam discharge patterns in Noxon Rapids Reservoir reduce concentration and exposure times (CET) of herbicides used for aquatic plant management. Herbicide applications during periods of low dam discharge may increase herbicide CETs and improve efficacy. Applications of rhodamine WT dye were monitored under peak (736 to 765 m3 s−1) and minimum (1.4 to 2.8 m3 s−1) dam discharge patterns to quantify water-exchange processes. Whole-plot dye half-life under minimal discharge was 33 h, a 15-fold increase compared with the dye treatment during peak discharge. Triclopyr concentrations measured during minimum discharge within the treated plot ranged from 214 ± 25 to 1,243 ± 36 µg L−1 from 0 to 48 h after treatment (HAT), respectively. Endothall concentrations measured during minimum discharge in the same plot ranged from 164 ± 78 to 2,195 ± 1,043 µg L−1 from 0 to 48 HAT, respectively. Eurasian watermilfoil (Myriophyllum spicatum L.) occurrence in the treatment plot was 66%, 8%, and 14% during pretreatment, 5 wk after treatment (WAT), and 52 WAT, respectively. Myriophyllum spicatum occurrence in the nontreated plot was 68%, 71%, and 83% during pretreatment, 5 WAT, and 52 WAT, respectively. Curlyleaf pondweed (Potamogeton crispus L.) occurrence in the treatment plot was 29%, 0%, and 97% during pretreatment, 5 WAT, and 52 WAT, respectively. Potamogeton crispus increased from 24% to 83% at 0 WAT to 52 WAT, respectively, in the nontreated plot. Native species richness declined from 3.3 species per point to 2.1 in the treatment plot in the year of treatment but returned to pretreatment numbers by 52 WAT. Native species richness did not change during the study in the nontreated reference plot. Herbicide applications during periods of low flow can increase CETs and improve control, whereas applications during times of high-water flow would shorten CETs and could result in reduced treatment efficacy.
Persian Studies in India and the Colonial Universities, 1857–1947
Authors: Bruce Gregory Maxwell 
Published: July 2022

AbstractThe establishment of the colonial universities in India was a watershed moment for the history of Persian studies on the subcontinent. Despite the rise of English and vernacular literatures in the nineteenth century, Persian remained an essential language of instruction in colonial colleges, with generations of Indian students studying Persian to pass university examinations. By closely studying university calendars and courses, this article demonstrates that the colonial universities created and sustained an ecosystem for Persian studies throughout the colonial period, as Orientalists and increasingly Indian Persianists continued to invest in Persian instruction and curricular development. The breadth, diversity, refinement, and expansion of Persian college curricula—which included texts from the classical Persian canon and contemporary literature written by Iranians and Indians—testify to the continued fluidity and dynamism of Persian studies throughout the period. Such a phenomenon demonstrates that the debates and engagement around the Persian language in colonial India contradict its depiction as an obsolete or entirely classical language, and also that colonial college curricula influenced which texts were edited, compiled, printed, translated, and commented upon.
From Persianate Cosmopolis to Persianate Modernity: Translating from Urdu to Persian in Twentieth-Century Iran and Afghanistan
Authors: Jabbari Alexander 
Published: July 2022

AbstractThis article examines twentieth-century Persian translations of Urdu-language works about Persian literature, focusing on two different Persian translations of an influential Urdu-language work on Persian literary history, Shiʿr al-ʿAjam (Poetry of the Persians), by Shibli Nuʿmani. The article offers a close, comparative reading of the Afghan and Iranian translations of Shiʿr al-ʿAjam in order to understand why two Persian translations of this voluminous text were published within such a short time period. These translations reveal how Indians, Afghans, and Iranians were invested in the same Persianate heritage, yet the emergence of a “Persianate modernity” undergirded by a cultural logic of nationalism rather than cosmopolitanism, along with Iran’s and Afghanistan’s differing relationships to India and Urdu, produced distinct approaches to translation.
Forlorn Arabs and Flying Americans: National Identity in the Early Childhood Curriculum of Postrevolutionary Iran, 1979–2009
Authors: Malekzadeh Shervin 
Published: July 2022

AbstractDrawing upon three decades of postrevolutionary textbooks, this article traces the development of the Arab Muslim as a recurring character in the early elementary curriculum of the Islamic Republic, set against the historical context of Iranian modernization and state formation in the twentieth and twenty-first centuries. Sympathy for the Arab by the postrevolutionary state included a rebuke and an affirmation: Look at what has happened to the Arabs who were not able to defend their homes and their homeland, and look at what has not happened to us. Set against the Palestinian Arab figure are the accomplishments of American scientists and inventors who feature prominently in the postrevolutionary curriculum as sources of emulation for young readers. Star turns from Thomas Edison, Alexander Graham Bell, and Orville and Wilbur Wright invite a reconsideration of the role of the foreign Other in the construction of Iranian national identity, notably the expectation that the dispossessed constitute natural allies in Iran's ceaseless struggle against “the West.” Islamization of the primary school curriculum since 1979 has not come at the expense of Iranian national identity but as its expression, elucidating the ways postrevolutionary educational materials can serve as a repository for tracing the continuities and permutations in depicting the Arab or Western Other as well as different civilizational ethos of the Islamic and Persianate world across time.
The Afghan Bachah and its Discontents: An Introductory History
Authors: Abdi Ali 
Published: July 2022

AbstractAfghanistan is one of the few places where the category ofbachah—the beardless young male—has maintained its aesthetic and erotic aspects in the public imagination. This article provides an introduction to the history of the various arrangements of man-bachahrelationships in Afghanistan from the rise of the Afghan kingdom in the late eighteenth century. By looking at both primary and secondary sources, alongside ethnographic materials gathered during fieldwork in Afghanistan between 2016 and 2021, this article shows how the content and implications of the category ofbachahhave been in constant flux and intimately connected to wider social, political, and economic developments both inside the country and beyond.
Digital Competence of Special Education Teachers: Impact, Challenges and Opportunities
Authors: Montenegro-Rueda Marta , Fernández-Batanero José María 
Published: July 2022

AbstractThe digital training of teachers in general, and especially special education teachers, has become a key axis for transforming the education system in favour of quality education, equality and equity. This study provides a systematic review of the literature in four databases (Scopus, ERIC, Dialnet and Web of Science) on the level of digital competence of special education teachers during the period 2010–2021. A total of 25 studies were analysed. The results were organised according to the description of the studies (year of publication, country of production, methodological approach) and the conceptual analysis of the network, which allowed us to assess the impact, challenges and opportunities of the digital competence of special education teachers. The main results of the review show digital competence as a pending subject for special education teachers. In this sense, this review includes suggestions that can be carried out when developing training actions to improve the level of digital competence of special education teachers. This training is crucial for the learning and academic success of students with special educational needs.