bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to organize for open innovation from the ground up: a microfoundations approach in a foodservice firm
Authors: Annosi Maria Carmela , Martini Antonella , Marzi Giacomo , Vignoli Matteo , Parra Héctor 
Published: August 2022

PurposeThis study aims to analyze what promotes the adoption of open innovation (OI) in the foodservice sector. Specifically, it seeks to shed light on the bottom-up mechanisms (the microfoundations) that allow a foodservice firm to organize for OI.Design/methodology/approachThe research design is an in-depth exploratory case study with 18 semi-structured interviews. The findings have been triangulated with documentation available on the corporate website, the project reports and direct observation. Data were analyzed using an inductive approach, coding individual interview transcripts.FindingsThis study identifies three categories of capabilities that have to be spread to different organizational levels: the capability to sense organizational triggers to change, to develop external collaborations and knowledge exchanges with different parties and the management's ability to be aware of organizational imperatives and the need to proceed with process adjustment. Results highlight the importance of sensing organizational triggers, allowing a quick switch between new strategies in implementing an OI approach. It was crucial for the company to co-develop new products and services with a large audience of stakeholders, not only limited to customers. The case remarks on the required ability of the organization and management team to activate mechanisms aimed at reconfiguring the competencies within each business unit, keeping an alignment with the needs of the stakeholders.Originality/valueThe study emphasizes the multi-level characteristics of OI and provides a framework for microfoundations on how to organize for OI. Results contribute to the recent debate on the skills and routines an organization should design and promote within their employees.
Do bankrupt firms recognize publicly available bad news in a timely fashion?
Authors: Khalifa Mariem , Trabelsi Samir 
Published: August 2022

PurposeThe purpose of this paper is to examine whether managers of bankrupt firms are more or less conditionally conservative in their financial reporting relative to non-bankrupt firms. The study further examines the cross-sectional differences in conditional conservatism among bankrupt and non-bankrupt firms.Design/methodology/approachThe study employs a sample of US firms to investigate conditional conservatism in firms that experience financial distress and go bankrupt relative to non-stressed non-bankrupt firms. The study also uses switching regression models to identify the drivers of the cross-sectional difference in conditional conservatism among bankrupt and non-bankrupt firms.FindingsEmpirical results show that bankrupt firms are timelier in recognizing bad news than good news when compared to non-bankrupt firms. The higher level of conditional conservatism in bankrupt firms is mainly driven by their higher levels of leverage and tax-reduction incentives. The cross-sectional analyses show that these results largely hold for more leveraged firms and firms with higher tax costs. Taken together, these results suggest that the conservative tendency of managers of bankrupt firms can stem from the agency problem between lenders and managers and from tax-decreasing motivations.Originality/valueThe novelty of the authors’ research stands in studying the drivers of the cross-sectional differences in conditional conservatism between bankrupt and non-bankrupt firms and specifically, the demonstration that taxation also induces conditional conservatism in the setting of ex post bankrupt firms.
A theoretical model and empirical analysis of university library readers' spatial cognition
Authors: Jiang Yiping , Chen Yanhua , Chi Xiaobo 
Published: August 2022

PurposeThe practice of renovation and construction of university libraries is flourishing, but how to attract readers to use the library is an issue that urgently needs to be explored. Spatial cognition is a subjective judgment of a person's tendency to take action in the future and implies behavioral intention. Based on the sensory–image–cognition relationship, a theoretical model of university library readers' spatial cognition is conducted, and the influencing factors and mechanisms of spatial cognition are explored based on empirical data to provide theoretical references for spatial practices in university libraries.Design/methodology/approachA visual and art-based mental map approach is introduced based on a questionnaire survey. The questionnaire is mainly used for the specific evaluation of spatial use and the breakdown of the detailed elements, while the mental map method is mainly used for the evaluation of readers' spatial cognition. Relevant empirical data are collected from the library of the Zhejiang University of Technology.FindingsThe results indicate that readers' spatial sensory experience and mental imagery have positive effects on readers' behavior via the mediator spatial cognition, readers' spatial sensory experience and mental imagery have a positive effect on readers' spatial cognition and spatial cognition has a significant effect on readers' behavior.Originality/valueThe main contribution of this study is to construct a theoretical model of readers' spatial cognition and to explore the factors that have an impact on spatial cognition and the influence of cognition on behavior. This provides a more rational and in-depth thinking paradigm for the study of university library space and provides theoretical references for library practice.
Productivity Debacle in the UK: Do Post‐crisis Firm Cohorts Explain the Performance Puzzle?
Authors: Douch Mustapha , Edwards Huw , Mallick Sushanta 
Published: August 2022

AbstractThis paper investigates how the aftermath of the 2008 crisis affected firm productivity in the UK, focusing particularly on the cohort effect of firms established after 2008 – a previously overlooked aspect of the crisis – as well as the interaction with access to credit, which we test using firm‐specific and time‐varying credit scores. For identification, a matched sample is used based on credit score, firm age, size and ownership status, combining propensity score matching with difference‐in‐differences. While we find evidence that smaller firm size and changes in credit conditions affect productivity, about half of the difference in productivity remains unexplained. When we extend the matching analysis to examine across sectors and cohorts, we find that the low productivity performance during the years 2011–2016 is driven primarily by newer firms in the services sector, rather than in manufacturing. Within services, the underlying productivity puzzle is driven by a cessation of output growth in high‐productivity financial services, while abundant labour supply has led to a ‘levelling down’ of performance of newer firms in other services, converging towards the relatively low‐productivity manufacturing.
A novel approach for forensic identification of automotive paints using optical coherence tomography and multivariate statistical methods
Authors: Wu Di , Wu Qiong , Lu Yifan , Wang Chengming , Yv Siyi , Wang Lei , Zeng Haoran , Sun Yijian , Li Zhigang , Gao Shuhui , Zhang Ning 
Published: August 2022

AbstractAutomotive paint is one of the most important evidence in solving vehicle‐related criminal cases. It contains the critical information about the suspected vehicle, providing essential clues for the investigation. In this study, a novel approach based on optical coherence tomography combined with multivariate statistical methods was proposed to facilitate rapid, accurate and nondestructive identification of different brands of automotive paints. 164 automotive paint samples from 8 different manufacturers were analyzed by a spectral‐domain optical coherence tomography system (SD‐OCT). Two‐dimensional cross‐sectional OCT images and three‐dimensional OCT reconstruction of vehicle paints of different paints were obtained to show the internal structural differences. Visual discrimination of A‐scan data after registration and averaging processing was first used to distinguish different samples. An scanning electron microscope was utilized to obtain the cross‐sectional image of the sample to evaluate the effectiveness of OCT technique. Then the original A‐scan data, first derivative data and second derivative data of 136 paints with four layers from 7 different manufacturers were collected. Multivariate statistical methods, including principal component analysis (PCA), multi‐layer perceptron (MLP), k‐nearest neighbor (KNN) algorithm and Bayes discriminant analysis (BDA), were used to analyze different datasets. The results show the hybrid PCA and BDA model based on the first derivative OCT data achieved the best result of 100% accuracy on the testing dataset for identifying automotive paints. It is demonstrated that the OCT technique combined with multivariate statistics could be a promising method for identifying the automotive paints rapidly and accurately.
Empirical analysis of the relationship between labour cost stickiness and labour reforms in Spain
Authors: Argilés‐Bosch Josep Mª. , Garcia‐Blandón Josep , Ravenda Diego 
Published: August 2022

AbstractThis study performs an empirical analysis on the relationship between labour cost stickiness and the decrease in employment protection in the Spanish labour reforms in 2010 and 2012. Following these reforms, the sticky behaviour of labour costs substantially decreased with respect to the pre‐reform period. All constituents of total labour costs followed a similar pattern: wages, social security contributions and number of employees. Results are robust to different models, estimation methods, periods of time, and industries, as well as with respect to endogeneity concerns.
Impact of extracorporeal shockwave therapy for erectile dysfunction and Peyronie's disease on reproductive and hormonal testicular function
Authors: Manfredi Celeste , Arcaniolo Davide , Amicuzi Ugo , Spirito Lorenzo , Napolitano Luigi , Crocerossa Fabio , Paoletta Marco , Gisone Stefano , Cirillo Paolo , Crocetto Felice , Bellastella Giuseppe , De Sio Marco , Imbimbo Ciro 
Published: August 2022

AbstractIntroductionExtracorporeal shock wave therapy is an established treatment for erectile dysfunction and Peyronie's disease. Concerns regarding the safety of extracorporeal shock wave therapy for andrological purposes on testicular function were raised by animal studies.AimTo evaluate the impact of extracorporeal shock wave therapy for erectile dysfunction or Peyronie's disease on reproductive and hormonal testicular function.MethodsWe designed a prospective controlled study in which consecutive patients were enrolled. Males aged between 18 and 40 years with mild vasculogenic erectile dysfunction or acute inflammatory Peyronie's disease and normozoospermia were included. All enrolled patients were offered extracorporeal shock wave therapy, and subjects who refused extracorporeal shock wave therapy for any reason were considered as the Control group. All patients in the Intervention group were treated with DUOLITH SD1 T‐TOP by a single expert urologist. Semen analysis and serum total testosterone dosage were performed before the start (T0) and 3 months after the end of extracorporeal shock wave therapy (T1) in Intervention group. The same parameters were evaluated after the extracorporeal shock wave therapy refusal (T0) and at the end of the following 3 months (T1) in Control group. Normozoospermia was chosen as the primary outcome, serum total testosterone concentration was selected as the secondary outcome.ResultsA total of 94 patients were enrolled in the study (48 Group A, 46 Group B). At T0, all patients were normozoospermic in both groups (p = 0.563), and no significant difference in mean ± SD total testosterone levels was recorded between the groups (582.5 ± 107.2 vs. 634.6 ± 108.4 ng/dl; p = 0.221). At T1, no significant deterioration (p > 0.05) in semen parameters was recorded in both groups. Only a statistically significant reduction in seminal pH was found after extracorporeal shock wave therapy compared to baseline (7.9 ± 0.3 vs. 7.5 ± 0.2; p < 0.001) and untreated patients (7.8 ± 0.2 vs. 7.5 ± 0.2; p < 0.001). No significant difference in total testosterone levels was recorded in Intervention group after extracorporeal shock wave therapy compared to baseline (p = 0.584).ConclusionExtracorporeal shock wave therapy in erectile dysfunction and Peyronie's disease patients does not seem to affect reproductive and hormonal testicular function.
Combined oral contraceptives containing estradiol valerate vs ethinylestradiol on coagulation: A randomized clinical trial
Authors: Haverinen Annina H. , Luiro Kaisu M. , Szanto Timea , Kangasniemi Marika H. , Hiltunen Leena , Sainio Susanna , Piltonen Terhi T. , Lassila Riitta , Tapanainen Juha S. , Heikinheimo Oskari 
Published: August 2022

AbstractIntroductionContraceptives containing ethinylestradiol (EE) induce changes in the coagulation system and are associated with a risk of venous thromboembolism. However, studies comparing the effects of combined oral contraceptives containing EE and low‐potency estrogens (ie, estradiol [E2] and estradiol valerate [EV]) on coagulation biomarkers are limited. This study represents secondary outcomes of a randomized trial comparing combined oral contraceptives containing EV + dienogest (DNG), EE + DNG, and DNG alone on selected coagulation biomarkers. We could compare the specific effects of the different estrogen components owing to the inclusion of preparations containing the same progestin.Material and methodsWe enrolled 59 healthy, 18‐ to 35‐year‐old, non‐smoking women, of whom three discontinued. The participants were randomly allocated to 9 weeks of continuous treatment with EV 2 mg + DNG 2–3 mg (n = 20), EE 0.03 mg + DNG 2 mg (n = 20), or DNG 2 mg (n = 19). Blood samples were collected at baseline and after 9 weeks. We assessed coagulation in vitro by thrombin generation using the Calibrated Automated Thrombogram. Thrombin generation was evaluated by lag time, time to thrombin peak, thrombin peak, and endogenous thrombin potential in response to tissue factor (1 pm). In vivo coagulation assessment was based on levels of prothrombin fragment 1 + 2 (F1 + 2) (thrombin generation) and D‐dimer (fibrin turnover). Clinical trial registration: NCT02352090.ResultsLag time and time to thrombin peak remained unaltered after exposure to EV + DNG, whereas EE + DNG shortened both lag time (mean percentage change −24%, 95% confidence interval [CI] −32% to −15%; p < 0.01) and time to thrombin peak (−26%, 95% CI −37% to −16%; p < 0.01). EV + DNG induced lower thrombin peak and endogenous thrombin potential than EE + DNG (peak; +45%, 95% CI 22%–67% vs +147%,95% CI 96%–198%; p < 0.01, and endogenous thrombin potential; +26%, 95% CI 15%–38% vs +64%, 95% CI 51%–76%; p < 0.01). Median F1 + 2 levels remained unchanged with EV + DNG (p = 0.22) but increased within normal ranges with EE + DNG (from 152 pmol/L, 95% CI 127–206] pmol/L to 194 pmol/L, 95% CI 149–250 pmol/L, p = 0.04). The within‐group change in D‐dimer levels was not significant in any of the groups. DNG alone did not affect these biomarkers.ConclusionsBoth in vitro and in vivo thrombin generation was lower after exposure to EV + DNG compared with EE + DNG. The lower thrombin generation measures after treatment with EV + DNG indicate less enhancement of coagulation potential and suggest that EV may be favorable to EE as a component of combined oral contraceptives.
Parthanatos participates in glutamate‐mediated HT22 cell injury and hippocampal neuronal death in kainic acid‐induced status epilepticus rats
Authors: Wang Xue , Zhang Wuqiong , Ge Pengfei , Yu Miaomiao , Meng Hongmei 
Published: August 2022

AbstractAimsEpileptic seizures or status epilepticus (SE) can cause hippocampal neuronal death, which has detrimental effects. Parthanatos, a new form of programmed cell death, is characterized by hyperactivation of poly (ADP‐ribose) polymerase‐1 (PARP‐1), excessive synthesis of poly ADP‐ribose polymer, mitochondrial depolarization, and nuclear translocation of apoptosis‐inducing factor, observed in various neurodegenerative disorders but rarely reported in epilepsy. We aimed to investigate whether parthanatos participates in the mechanism of seizure‐induced hippocampal neuronal death.MethodsGlutamate‐mediated excitotoxicity cell model was used to study the mechanism of seizure‐induced cell injury. Injection of kainic acid into the amygdala was used to establish the epileptic rat model. Corresponding biochemical tests were carried out on hippocampal tissues and HT22 cells following indicated treatments.ResultsIn vitro, glutamate time‐dependently induced HT22 cell death, accompanied by parthanatos‐related biochemical events. Pretreatment with PJ34 (PARP‐1 inhibitor) or small interfering RNA‐mediated PARP‐1 knockdown effectively protected HT22 cells against glutamate‐induced toxic effects and attenuated parthanatos‐related biochemical events. Application of the antioxidant N‐acetylcysteine (NAC) rescued HT22 cell death and reversed parthanatos‐related biochemical events. In vivo, PJ34 and NAC afforded protection against SE‐induced hippocampal neuronal damage and inhibited parthanatos‐related biochemical events.ConclusionParthanatos participates in glutamate‐induced HT22 cell injury and hippocampal neuronal damage in rats following epileptic seizures. ROS might be the initiating factor during parthanatos.
Carbon dioxide limitation of benthic primary production in a boreal lake
Authors: Hamdan Mohammed , Karlsson Jan , Byström Pär , Al‐Haidarey Mohammed J. , Ask Jenny 
Published: August 2022

Abstract

Gross primary production (GPP) by benthic microalgae growing on soft sediments is an important contributor to lake productivity in many lakes world‐wide. As benthic microalgae have access to nutrients in the sediment they have been regarded as primarily controlled by light, while the role of CO2 as a limiting factor for benthic GPP in lake ecosystems is largely unknown.

In this study, we experimentally tested for CO2 limitation of benthic GPP by collecting littoral surface sediments, with associated benthic microalgae, from a typical boreal lake. Intact sediment cores were incubated at different depths (light conditions) after addition of dissolved inorganic (bicarbonate) or organic (DOC; glucose) carbon as direct and indirect sources of CO2, respectively.

Benthic microalgal GPP was stimulated by both dissolved inorganic carbon and DOC additions at high, but not at low, light levels.

This study shows that benthic microalgal GPP can be CO2‐limited when light is not limiting and suggests that both direct (e.g., via groundwater inflow) and indirect (via mineralisation of DOC) CO2 supply can stimulate benthic GPP.
Design details for overdose education and take‐home naloxone kits: Codesign with family medicine, emergency department, addictions medicine and community
Authors: Sellen Kate , Goso Nick , Halleran Laura , Mulvale‐Fletcher Alison , Sarmiento Felipe , Ligabue Filipe , Handford Curtis , Klaiman Michelle , Milos Geoffrey , Wright Amy , Charles Mercy , Sniderman Ruby , Hunt Richard , Parsons Janet A. , Leece Pamela , Hopkins Shaun , Shahin Rita , Jüni Peter , Morrison Laurie , Campbell Douglas M. , Strike Carol , Orkin Aaron ,   SOONER Investigators
Published: August 2022

AbstractIntroductionOverdose education and naloxone distribution (OEND) programmes equip and train people who are likely to witness an opioid overdose to respond with effective first aid interventions. Despite OEND expansion across North America, overdose rates are increasing, raising questions about how to improve OEND programmes. We conducted an iterative series of codesign stakeholder workshops to develop a prototype for take‐home naloxone (THN)‐kit (i.e., two doses of intranasal naloxone and training on how to administer it).MethodsWe recruited people who use opioids, frontline healthcare providers and public health representatives to participate in codesign workshops covering questions related to THN‐kit prototypes, training on how to use it, and implementation, including refinement of design artefacts using personas and journey maps. Completed over 9 months, the workshops were audio‐recorded and transcribed with visible results of the workshops (i.e., sticky notes, sketches) archived. We used thematic analyses of these materials to identify design requirements for THN‐kits and training.ResultsWe facilitated 13 codesign workshops to identify and address gaps in existing opioid overdose education training and THN‐kits and emphasize timely response and stigma in future THN‐kit design. Using an iterative process, we created 15 prototypes, 3 candidate prototypes and a final prototype THN‐kit from the synthesis of the codesign workshops.ConclusionThe final prototype is available for a variety of implementation and evaluation processes. The THN‐kit offers an integrated solution combining ultra‐brief training animation and physical packaging of nasal naloxone to be distributed in family practice clinics, emergency departments, addiction medicine clinics and community settings.Patient or Public ContributionThe codesign process was deliberately structured to involve community members (the public), with multiple opportunities for public contribution. In addition, patient/public participation was a principle for the management and structuring of the research team.