bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of right ventricular functions in acromegaly: comparison of active disease with remission
Authors: Pirhan Osman , Ertuğrul Abdülcelil Sait , Yıldız Cennet , Karabulut Dilay , Pehlivan Bahar , Piskinpasa Hamide , Dogansen Sema Ciftci , Mert Meral 
Published: September 2022

Aim Cardiac involvement in acromegaly is defined as acromegalic cardiomyopathy, an insidious and chronic disease. Previous research on acromegalic cardiomyopathy was largely focused on morphological and functional assessment of the left heart. Since the literature data regarding right heart function in acromegalic patients are limited, we aimed to evaluate the structure and function of the right heart in such patients.Material and Methods We included 43 adult participants as the acromegaly group and 42 individuals as the control group. All patients underwent echocardiographic evaluation. The results were compared between acromegaly and control groups and between active and controlled acromegaly groups.Results The acromegaly group had increased interventricular septum thickness, right ventricular (RV) free wall thickness, right atrium (RA) minor diameter, RV basal and longitudinal diameters, RV end-diastolic and end-systolic areas, E / E’ ratio, isovolumetric relaxation time, and RV ejection time. The E / A ratio and E’ velocity were reduced. GH and IGF-1 were positively correlated with RV longitudinal diameter, indexed RA minor-axis dimension, and indexed RV end-diastolic area. Patients with active acromegaly had increased RV index of myocardial performance (RVIMP) and isovolumetric contraction time and shortened RV ejection time compared to patients in remission. A RVIMP value of 0.435 predicted active acromegaly with a sensitivity and specificity of 0.83 and 0.64, respectively (p=0.002).Conclusions Increases in the size and diameters of the right heart chambers along with RV free wall thickness may be attributed to acromegalic cardiomyopathy. RVIMP, isovolumetric contraction time, and ejection time are parameters that can be used in the evaluation of active acromegaly disease.
Detection of ESBL producing E.coli and Klebsiella spp in urinary tract infection due to long exposure of catheterize condition in Covid positive patient admitted in HDU
Authors: Nandi Dilip Kumar , Bera Shyam Sundar , Pathak Traun Kumar , Sarkar Arunabha , Pathak Devnil , Mitra Mousumi , Nandi Purna , Mitra Sudeep , Sasmal Bandita , Bhattacharya Kaberi 
Published: September 2022

Long exposure of broad spectrum antibiotic can severe causes of extended-spectrum beta-lactamase (ESBL) production within bacteria in UTI patient. Community-acquired infections due to ESBL producing and both are rising worldwide. To assess the prevalence and antibiotics resistance patterns of ESBL-producing and Klebsiella spp. from covid positive patient admitted in HDU with catheterized condition. A hospital-based cross-sectional study was conducted on Salboni Super speciality Hospital (Covid Level-IV) at West Bengal, India from August 2020 to August2021and a total of 1116 urine samples were collected from catheterized patient admitted in male and female HDU due to exposure of covid. Samples were cultured on CLED agar and then Identification of the isolates was done by Gram's staining followed by biochemical tests. Antibiotic susceptibility testing was done by modified Kirby-Bauer disc diffusion method and interpretation was done following Clinical and Laboratory Standard Institute (CLSI) guidelines foe detection of ESBL producing and . present study showed 51.6% (n-326) and 37.2% (n-235) Klebsiella spp. from 631 significant growths from both male and female patients. Out of this, total ESBL producing and spp. seen 55% (n-309) from both male and femle patient in different age group. Finally Isolated ESBL producing i 45.9 % (n-142) and ESBL producing Klebsiella spp. 54 % (n- 167) from both male and female HDU.Detection of ESBL producing and due to prolonged uses of broad spectrum antibiotic vigorously. The occurrence of multidrug resistance to the third-generation cephalosporins, aminoglycosides, fluoroquinolones, trimethoprim-sulfamethoxazole, and tetracyclines is more common among ESBL producers. It may help to detect other organism in same condition, so that it will be importance in clinical aspect of future treatment for clinician.
Uma análise discursiva foucaultiana das visibilidades do macho em aplicativos de relacionamento
Authors: Cardoso e Silva Elivelto , De Sousa Katia Menezes 
Published: September 2022

Neste artigo examinamos as visibilidades produzidas discursivamente a respeito da identificação sexual de homens em busca de outros homens para interações afetivo-sexuais em aplicativos de relacionamento. O objetivo da análise é construir problematizações a respeito da gramática binária “macho/fêmea” reproduzida online na busca por visibilidades sexuais que se enquadrem nesta gramática e, por sua vez, valorizem homens vistos como machos. Para isso, consideramos dados produzidos de 2017 a 2021 em pesquisa online em perfis de usuários do Grindr e do Scruff – ambos encontrados em lojas online de aplicativos para celulares. Seguindo a constatação de Deleuze sobre o método arqueológico de Michel Foucault, consideramos, diante do problema relativo às relações homoafetivas e de gêneros, os focos de poder/resistência como possibilitadores da formação do corpus que se centrou na disputa online “macho vs gay”, observada em 580 prints de autodescrições de usuários dos dois aplicativos. As reflexões acerca do método arqueológico foucaultiano e das considerações deleuzianas, que colocam dizibilidades e visibilidades como em constantes capturas recíprocas sob um primado do enunciado, nos possibilitaram compreender como se configura as valorizações a respeito de sujeitos que fazem ver, em seu funcionamento corporal, a visibilidade da macheza heterossexual.
Time Series Modeling and Forecasting of Monthly Mean Sea Level (1978 – 2020): SARIMA and Multilayer Perceptron Neural Network
Authors: Chi Yeong Nain 
Published: September 2022

The primary purpose of this study was to demonstrate the role of time series model in predicting process and to pursue analysis of time series data using long-term records of monthly mean sea level from January 1978 to October 2020 at Grand Isle, Louisiana. Following the Box–Jenkins methodology, the ARIMA(1,1,1)(2,0,0)[12] with drift model was selected to be the best fitting model for the time series, according to the lowest AIC value in this study. Empirically, the results revealed that the MLP neural network model performed better compared to the ARIMA(1,1,1)(2,0,0)[12] with drift model at its smaller MSE value. Hence, the MLP neural network model not only can provided information which are important in decision making process related to the future sea level change impacts, but also can be employed in forecasting the future performance for local mean sea level change outcomes. Understanding past sea level is important for the analysis of current and future sea level changes. In order to sustain these observations, research programs utilizing the resulting data should be able to improve significantly our understanding and narrow projections of future sea level rise and variability.
Impacts of photoselective bunch zone shading on the volatile composition and sensory attributes for <i>Vitis vinifera</i> L. cv. Riesling
Authors: Grebneva Yevgeniya , Bilogrevic Eleanor , Rauhut Doris , Herderich Markus J. , Hixson Josh L. 
Published: September 2022

Photoselective shading is a process that modulates the radiation intensity in specific regions of the electromagnetic spectrum. It is a common practice in horticulture to manipulate specific plant physiological responses, but to date has only received minimal attention in viticulture. The potent odorant 1,1,6-trimethyl-1,2-dihydronaphthalene (TDN) is of particular relevance for aged Riesling wine, which are also known to be impacted by the magnitude of bunch zone light exposure during berry development. Hence, in this study, the effect of photoselective bunch zone shading on the formation of TDN in wine was investigated across two consecutive growing seasons. Applying red, black or green shade cloth (SC) to the bunch zone provided unique bunch zone light environments and yielded distinct differences in grape and wine composition compared with the unshaded control. Overall, bunch zone shading through shade cloth was effective in reducing overall photosynthetically active radiation compared to the control and the photoselectivity of the SC treatments differently affected a number of grape and wine measures. Fruit yield was somewhat but not significantly lower under black SC treatments, while juice pH was increased in grapes grown under green and black SC across both vintages compared to the control. Both grape sugar accumulation (P = 0.035) and ammonia nitrogen (P = 0.043) showed evidence of treatment effects, although with low F-statistics (4 and 3, respectively). Measures of hydrolytically released TDN in juice and free TDN concentrations in wine were lower in SC treatments. Unexpectedly, sensory descriptive analysis of the wines demonstrated that increased ‘kerosene-like’ aroma was not consistently associated with free TDN concentrations in wine. In summary, photoselective bunch shading was demonstrated to be an effective method for manipulating grape and wine outcomes and may aid in overcoming viticultural obstacles and quality impacts associated with climate change.
A Three-Dimensional Constitutive Model for Rocks Based on a Strain-Dependent Elastic Modulus
Authors: Li Z. , Fujii Y. , Kodama J. , Fukuda D. , Dassanayake A. B. N. , Sinkala P. 
Published: September 2022

Abstract
Our research group previously proposed a simple two-dimensional (2D) constitutive model for rocks to simulate not only the axial stress–axial strain relationship, but also the axial stress–lateral strain relationship, with few complicated equations. However, the failure envelope that it predicted was linear, and it did not consider the effect of the intermediate principal stress (σ2). In the present study, the authors modify this simple 2D model to have a convex failure criterion. Then, the model is extended to a simple three-dimensional (3D) model that well approximates true triaxial stress–strain curves for real rocks under specific values of σ2 and σ3 and uses only four parameters. However, the predicted peak stress–σ2 relationship is linear. Finally, a modified 3D model was developed, which exhibited the true triaxial convex failure criterion. The equations in this model are simpler than the conventional true triaxial failure criteria. The proposed models can be implemented with a finite element method to improve the design of rock structures.
Energy Chaos Characteristic Evolution Analysis of Sandstones during Multilevel Unloading Subject to Different Confining Pressures
Authors: Dang Shuang , Bi Jing , Zhao Yu , Wang Chaolin , Xia Kaizong , Gan Fei 
Published: September 2022

Abstract
In this study, multilevel and conventional unloading triaxial compression tests under different confining pressures are separately carried out to systematically reveal the deformation, energy evolution, and fracture characteristics of sandstone samples. Results show that under the multilevel unloading condition, the increase of the initial confining pressure has a more obvious inhibitory effect on the radial strain of sandstone, and the samples can fully exhibit elastic deformation and partial plastic deformation, showing obvious plastic characteristics. The radial energy growth factor is more sensitive than the axial energy growth factor during the process of confining pressure unloading, and the larger the initial confining pressure, the earlier the period-doubling bifurcation region and chaotic region are reached. To better understand the deformation and failure process of rock during engineering excavation, it is necessary to establish a constitutive relation describing the mechanical properties of rock. The three-step failure mode also proves that there are tensile and shear fractures in sandstone samples, in which the effects of tensile stress and shear stress are more or less interdependent in the failure process. It can be seen that multilevel unloading makes the energy conversion more adequate and reduces the sudden release of energy when the rock fails, reducing the possibility of rockburst and making the excavation unloading process safer. This will deepen the understanding of rock failure behavior and contribute to the better application of energy characteristics to relevant engineering practices.
Earthquake-Induced Stress Amplification and Rock Fragmentation within a Deep-Seated Bedding Fault: Case Study of the Daguangbao Landslide Triggered by the 2008 Wenchuan Earthquake (Ms=8.0)
Authors: Cui Shenghua , Pei Xiangjun , Yang Hailong , Yang Qingwen , Zhu Ling 
Published: September 2022

Abstract
The 2008 Wenchuan Ms 8.0 earthquake triggered the Daguangbao (DGB) landslide, of which the shear surface belongs to a thrust bedding fault 400 m below the carbonate slope. After the landslide, a 1.8 km-long inclined sliding face (0.3 km2) was exposed in the south source area. By using shaking table test, the contributions of the fault to the landslide sliding have been studied in this paper. The bedding fault in the test model is simplified as a weak layer with small elasticity and the carbonate layers as a hard layer with high elastic modulus, which is 296 times the weak one. The test records larger displacement amplitude in the upper hard layer than that in the lower one and larger pressure amplitude in the weak layer than that in the hard ones. We ascribed the stress amplification in the weak layer to time delay of shaking wave as wave velocity in the weak layer is only 1/15 of that in the hard layers. Such time delay gives rise to phase differences between the hard layers during shaking. The compressive stress amplification occurs in the weak layer when the upper hard layer moves downwards relative to the lower one; otherwise, tensile stress amplification occurs. It is suggested that this kind of stress amplification triggered an extensive fragmentation of the bedding fault rock mass during the Wenchuan earthquake, which can be verified by a good deal of gentle-dip and steep-dip cracks observed on site. It is proposed that stress amplification had caused a fast dropping of shear strength in the bedding fault to enhance the suddenness of DGB landslide initiation.
Carbon stock assessment on natural mangrove species of Avicennia marina in Pichavaram mangrove forest Southeast coast of India
Authors: Natarajan Manivannan , Ayyappan Saravanakumar , vajiravelu manigandan 
Published: September 2022

Abstract
Avecennia marina is potential mangrove plant and it exhibits high CO2 accumulation, rapid growth with high biomass and significant carbon storage in soil than other mangroves. The present study conducted to imply the carbon sequestration potential of mangrove along with their biomass and sediment characteristics for the year 2017. The study was conducted on natural stand of Avicennia marina at Pichavaram mangrove forest in Southeast coast of India. To highlight the significance of mangroves a comparative carbon stock assessment was made on natural stand of Avicennia marina, and with the non-mangrove barren habitat. The analysed parameters are leaf area index, net canopy photosynthesis, biomass, biomass carbon and soil characteristics such as, total organic carbon, total carbon, temperature, pore water salinity, moisture, bulk density, soil texture, nitrogen, phosphorous and potassium. The average measured value of leaf area index and net canopy photosynthesis were 1.66m2/m2, and 6.03 gC/m2. The level of nitrogen, phosphorous, potassium (NPK) were higher in A. Marina when compared to non-mangrove barren site. One way ANOVA was conducted for the soil sediment characteristic observed for the both site and no significant variation was observed except particle density, soil clay, loss of ignition and available potassium and phosphorous. In correlation analyses significant positive correlation was observed with temperature and soil while soil silt had negative correlation with bulk density, pore space, soil sand and clay. Temperature and sand content was lower than that of barren habitat. Soil moisture, bulk density, particle density, pore space, pore water salinity, soil silt and clay content showed higher value in mangrove soil than that of barren habitat. The present investigation revealed the total organic carbon (TOC) and total carbon (TC) was 7 fold higher in A. marina when compared to barren habitat.
Delta Oscillation Coupled Propagating Fast Ripples Precede Epileptiform Discharges in Patients with Focal Epilepsy
Authors: Weiss Shennan , Sheybani Laurent , Seenarine Nitish , Fried Itzhak , Sharan Ashwini , Wu Chengyuan , Engel Jerome , Sperling Michael , Nir Yuval , Staba Richard 
Published: September 2022

Abstract
Epileptiform spikes are brief (50-200 msec) sharply contoured waveforms in the electroencephalogram that are used to diagnose epilepsy and localize epileptogenic brain tissue. The mechanisms that spontaneously trigger epileptiform discharges are not yet elucidated. Fast ripples (FR, 200-600 Hz) are associated with epileptogenic brain tissue and may play critical roles in the epileptic network that generates seizures. We postulated that FR network interactions are involved in generating epileptiform spikes. Using macroelectrode stereo EEG recordings from a cohort of 46 patients we found that spatially propagating FR, in the seizure onset zone (SOZ), often was followed by an epileptiform spike (p<0.05). Propagating FR, compared to non-propagating FR, exhibited a distinct frequency and larger power (p<1e-10) and were strongly phase coupled to the peak of delta oscillation DOWN states during non-REM sleep (p<1e-10). While FR propagation was rare, all FR occurred with the highest probability, in the inter-ictal epoch, within +/- 400 msec of certain epileptiform spikes (p<0.05). Thus, a distinct sub-population of epileptiform spikes in the SOZ, are preceded, and perhaps triggered by, propagating FR that are coordinated by the DOWN state during non-REM sleep. Our results also imply that FR propagation plays a role in the epileptic network.
AuthROS: Secure Data Sharing Among Robot Operating Systems Based on Ethereum
Authors: Zhang Shenhui , Li Wenkai , Li Xiaoqi , Liu Boyi 
Published: September 2022

Abstract
The Robot Operating System (ROS) streamlines human processes, increasing the efficiency of various production tasks. However, the security of data transfer operations in ROS is still in its immaturity. Securing data exchange between several robots is a significant problem. This paper proposes \textit{AuthROS}, an Ethereum blockchain-based secure data sharing method, for robot communication. It is a ROS node authorization system capable of ensuring the immutability and security of private data flow between ROS nodes of any size. To ensure data security, AuthROS employs the smart contract for permission granting and identification, SM2-based key exchange, and SM4-based plaintext encryption techniques. In addition, we deploy a data digest upload technique to optimize data query and upload performance. Finally, the experimental findings reveal that AuthROS has strong security, time performance, and node forging in cases where data should be recorded and robots need to remain immobile.
Exploring the role of carbon and nitrogen metabolism in Chenopodium quinoa (Willd.) from the commencement of grain growth until maturity
Authors: Grewal Satvir Kaur , Gill Ranjit Kaur , Chandora Rahul 
Published: September 2022

Abstract
Co-ordination between carbon and nitrogen metabolism plays a vital role in maintaining the source-sink relationship between the reproductive structures (inflorescence and seed). The present investigation was carried out to study carbon and nitrogen metabolism in quinoa genotypes IC411824, IC411825, EC507747 and EC507742 at different stages of anthesis and post -anthesis, which could affect seed growth and maturity. Carbon metabolism enzymes such as acid invertase, sucrose synthase (cleavage), and sucrose phosphate synthase showed increased activity from 75 to 90 days after sowing (DAS) in inflorescence of quinoa genotypes, which might be responsible for the assimilation of carbohydrates required for seed development during the post-anthesis period. Activities of acid invertase and sucrose synthase (cleavage) were observed to be maximum in seeds of quinoa genotypes at 110 DAS, then decreased as seed development progressed, reaching a minimum near seed maturity at 124 DAS. Nitrogen metabolizing enzymes such as glutamate dehydrogenase and nitrite reductase plays a central role in the re- assimilation of amides from the amino group of asparginase at 90 DAS in inflorescence and 124 DAS at seed maturity. IC411825 and EC507747 genotypes had better availability to assimilate the nutrients and their remobilization during the onset of seed development. The pattern of carbon and nitrogen metabolism enzymes at different stages of inflorescence and grain development influenced the source sink relationship mediating partitioning and accumulation of assimilates during of anthesis and post anthesis periods of grain development in quinoa, which eventually led to grain development and yield establishment.
Gene Expression and Early Radiation Response of Two Distinct Neuroblastoma Cell Lines
Authors: Ritner Carissa , Popovic Jelena , Abouzeid Aushra , Li Ya , Paunesku Tatjana , Papineni Rao , Woloschak Gale 
Published: September 2022

Abstract
Simple Summary: Neuroblastoma is a common pediatric cancer that spreads systemically, making therapy difficult. Tumors are frequently resistant to radiation therapy, a last line of defense in patients with aggressive disease. In this study, we found that there are distinct gene expression patterns dependent on neuroblastoma subtype; however, both neuroblastoma types examined showed only subtle gene expression differences early following radiation exposure. This indicates that while neuroblastoma tumors are diverse in phenotype and gene expression, they have similarly stable gene expression and resistance during early response to stressors such as radiation.
Abstract: External beam radiation is infrequently used for treatment of pediatric cancer such as neuroblastoma, typically reserved for palliative care in patients with aggressive metastatic disease who fail to respond to alternative treatments. Understanding effects of radiation on neuroblastoma cells could improve efficacy of this final means of therapy to decrease tumor burden and stabilize the disease. In this study, clonogenic assays were used to establish radiation responses for SK-N-AS and SK-N-DZ cell lines; cells were then irradiated at doses that cause 90% cell killing based on clonogenic assay and their RNA isolated and subjected to microarray analysis. In addition, cells were transfected with pre-miRNA constructs that led to overexpression of microRNAs miR-34a and miR-1228. Statistically significant differences were detected for expression of several thousands of genes when the two cell lines were compared with each other. In comparison, radiation led only to minor gene expression differences of less than two-fold at the 1h post-irradiation timepoint in both cell lines. Overexpression of miR-34a and miR-1228 in either cell line did not change this outcome. Therefore, neuroblastoma cell lines SK-N-AS and SK-N-DZ are phenotypically diverse and gene expression differences between them are extensive. At the same time, the regulation of gene expression in both of these cell lines is in a stable equilibrium at early timepoints after exposure to ionizing radiation.