bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of the short stitch technique for midline abdominal closure on incisional hernia (ESTOIH): randomized clinical trial
Authors: Fortelny René H , Andrade Dorian , Schirren Malte , Baumann Petra , Riedl Stefan , Reisensohn Claudia , Kewer Jan Ludolf , Hoelderle Jessica , Shamiyeh Andreas , Klugsberger Bettina , Maier Theo David , Schumacher Guido , Köckerling Ferdinand , Pession Ursula , Hofmann Anna , Albertsmeier Markus 
Published: June 2022

Abstract

Background
Incisional hernia remains a frequent problem after midline laparotomy. This study compared a short stitch to standard loop closure using an ultra-long-term absorbent elastic suture material.

Methods
A prospective, multicentre, parallel-group, double-blind, randomized, controlled superiority trial was designed for the elective setting. Adult patients were randomly assigned by computer-generated sequence to fascial closure using a short stitch (5 to 8 mm every 5 mm, USP 2-0, single thread HR 26 mm needle) or long stitch technique (10 mm every 10 mm, USP 1, double loop, HR 48 mm needle) with a poly-4-hydroxybutyrate-based suture material (Monomax®). Incisional hernia assessed by ultrasound 1 year after surgery was the primary outcome.

Results
The trial randomized 425 patients to short (n = 215) or long stitch technique (n = 210) of whom 414 (97.4 per cent) completed 1 year of follow-up. In the short stitch group, the fascia was closed with more stitches (46 (12 s.d.) versus 25 (7 s.d.); P &lt; 0.001) and higher suture-to-wound length ratio (5.3 (2.2 s.d.) versus 4.0 (1.3 s.d.); P &lt; 0.001). At 1 year, seven of 210 (3.3 per cent) patients in the short and 13 of 204 (6.4 per cent) patients in the long stitch group developed incisional hernia (odds ratio 1.97, 95 per cent confidence interval 0.77 to 5.05; P = 0.173).

Conclusion
The 1-year incisional hernia development was relatively low with clinical but not statistical difference between short and long stitches.
Registration number: NCT01965249 (http://www.clinicaltrials.gov)
AcetoBase Version 2: a database update and re-analysis of formyltetrahydrofolate synthetase amplicon sequencing data from anaerobic digesters
Authors: Singh Abhijeet , Schnürer Anna 
Published: June 2022

Abstract
AcetoBase is a public repository and database of formyltetrahydrofolate synthetase (FTHFS) sequences. It is the first systematic collection of bacterial FTHFS nucleotide and protein sequences from genomes and metagenome-assembled genomes and of sequences generated by clone library sequencing. At its publication in 2019, AcetoBase (Version 1) was also the first database to establish connections between the FTHFS gene, the Wood–Ljungdahl pathway and 16S ribosomal RNA genes. Since the publication of AcetoBase, there have been significant improvements in the taxonomy of many bacterial lineages and accessibility/availability of public genomics and metagenomics data. The update to the AcetoBase reference database described here (Version 2) provides new sequence data and taxonomy, along with improvements in web functionality and user interface. The evaluation of this latest update by re-analysis of publicly accessible FTHFS amplicon sequencing data previously analysed with AcetoBase Version 1 revealed significant improvements in the taxonomic assignment of FTHFS sequences.
Database URL: https://acetobase.molbio.slu.se
Adverse clinical events during the first 24 h of bedrest following cardiac electronic device implantation: a prospective observational study
Authors: Orlando Fabio , Giuffrida Silvia , Vicari Raffaello , Sansalone Andrea , Dell’Avo Alessandro , Bernasconi Stefano , Villa Michele 
Published: June 2022

AbstractAimsTo describe the incidence and impact of adverse clinical events (ACEs) during first 24 h of bedrest of patients after cardiac implantable electronic device (CIED) implantation.Methods and resultsWe conducted a prospective observational study of patients aged over 18 years undergoing elective placement of permanent bicameral pacemaker (PM), cardiac resynchronization therapy (CRT) PM, CRT defibrillator, or implantable cardioverter-defibrillator. Patients were maintained on bedrest post-operatively for 24 h and delirium, post-operative urinary retention, severe post-operative pain, pressure ulcer, and sleep disturbance were recorded using standardized assessments. Of 90 patients, 66 (73.3%) were male and average age was 76 ± 10 years. The median time to first mobilization was 23 (21–24) h. The adverse clinical events occurred in 48/90, with severe pain (38/90), sleep disturbance (12/90), delirium (9/90), and urinary retention requiring urinary catheterization (8/90) most frequent. Patients receiving implantable cardioverter-defibrillator or CRT defibrillator experienced ACEs significantly more frequently than those receiving PM. Adverse clinical event was associated with prolonged hospital stay [odds ratio (OR) 2.5; 95% confidence interval (CI) 1.16–6.17]. Patients with delirium were more dependent for daily living activities on admission (OR 8.0; 95% CI 1.55–41.3).ConclusionAdverse clinical events frequently occur post-insertion of a CIED and impact patient clinical course and experience. The progressive increase in ageing and frailty of CIED implant candidates requires special nursing attention to improve patients’ satisfaction and to prevent increased healthcare resource use.
The Making of Age-Friendly Universities: A Scoping Review
Authors: Montayre Jed , Maneze Della , Salamonson Yenna , Tan Josh D L , Possamai-Inesedy Alphia 
Published: June 2022

Abstract

Background and Objectives
The age-friendly university (AFU) initiative embodies the collaborative efforts of promoting age inclusivity and diversity in higher education, embracing lifelong learning and civic participation in older people. This scoping review aims to explore the conceptualization of AFU, the experiences, and the strategies used in operationalizing the AFU principles of participating universities in becoming members of the age-friendly university network.

Research Design and Methods
A search of peer-reviewed papers published from 2012 to July 2021, conducted in nine databases using JBI scoping review methodology, found 1,752 articles. Of these, 13 papers were eligible for inclusion.

Results
Three themes were identified as key to becoming an AFU: (a) interdisciplinary collaboration within the university; (b) strong partnership with the community; and (c) alignment with global priorities and initiatives. Furthermore, identifying barriers to physical access in universities, such as signage, walkways, and transportation, addressing the less tangible issues of ageism and promoting intergenerational learning were essential to promote engagement of older people.

Discussion and Implications
This review underscores the need for a multidisciplinary approach within the university, the reciprocal benefits of authentic university–community collaborations, and the advantages of harnessing international resources and global influence to becoming an AFU. Although the principles of the AFU remain aspirational, the ideals championed by the pioneering universities in the AFU network brought the mutual benefits of intergenerational learning, the challenges and support required for older learners to the fore, propelling the AFU agenda forward.
Mesenchymal stem cell-derived extracellular vesicles alleviate cervical cancer by delivering microRNA-331-3p to reduce LIM zinc finger domain containing 2 methylation in tumor cells
Authors: Yang Shanshan , Wang Le , Gu Lina , Wang Zhao , Wang Yuan , Wang Jianan , Zhang Yunyan 
Published: June 2022

Abstract
The aim of this study is to investigate if extracellular vesicles (EVs) from bone marrow mesenchymal stem cells (BMSCs) deliver microRNA (miR)-331-3p to regulate LIM zinc finger domain containing 2 (LIMS2) methylation in cervical cancer cells. Cervical cancer cells were incubated with EVs from BMSCs with altered expression of miR-331-3p, DNA methyltransferase 3 alpha (DNMT3A) or/and LIMS2 and then subjected to 5-ethynyl-2′-deoxyuridine, Transwell, flow cytometry and western blotting analyses. Dual-luciferase reporter assay was conducted to verify the binding between miR-331-3p and DNMT3A. A xenograft model was established to evaluate the effect of BMSC-derived EV-miR-331-3p on cervical tumor growth. miR-331-3p was lowly and DNMT3A was highly expressed in cervical cancer. BMSC-derived EVs delivered miR-331-3p to control the behaviors of cervical cancer cells. miR-331-3p inhibited the expression of DNMT3A by binding DNMT3A mRNA. DNMT3A promoted LIMS2 methylation and reduced the expression of LIMS2. Overexpression of DNMT3A or silencing of LIMS2 in BMSCs counteracted the tumor suppressive effects of miR-331-3p. BMSC-derived EV-miR-331-3p also inhibited the growth of cervical tumors in vivo. BMSC-derived EVs alleviate cervical cancer partially by delivering miR-331-3p to reduce DNMT3A-dependent LIMS2 methylation in tumor cells.
Biological sex: an understudied factor driving disease susceptibility in pigs
Authors: Moeser Adam J , Roney Andrew , Fardisi Mahsa , Thelen Kyan 
Published: June 2022

AbstractBiological sex is a major host factor influencing risk for infectious disease-associated mortality, and chronic inflammatory and metabolic diseases. Research in human and rodent models –has revealed sex differences that exist across organ systems during health and disease that may contribute to sex biases in disease risk. Despite the robust and growing literature on the role of sex as a risk factor in human disease, comparatively little attention has been focused on investigating the role of biological sex in disease susceptibility in agriculturally important animal populations such as the pig. To date, comparisons between sexes have focused on carcass composition, growth rate, and feed efficiency in pigs. However, there is a large gap in the literature regarding the effects of biological sex on other integral aspects of health and disease. The objective of this review is to highlight the available literature reporting sex differences in pig health and biology with an emphasis on sex differences in mortality, immunity, and gastrointestinal (GI) physiology and to address biological sex as a significant biological variable in disease risk and research study design. A basic overview of the biology of sex differences including the major hormonal and genetic/chromosomal mechanisms of sexual differentiation and the developmental periods in which sex differences emerge will be covered. This review will also discuss how production-relevant management and environmental factors (e.g., wean age, castration, stress, and nutrition) interact with biological sex to shape host immune and GI development and function. Perceived gaps in knowledge and areas of future research will also be discussed.
Greater responses of flower phenology ofKobresia pygmaeacommunity to precipitation addition than to constant and stepwise warming
Authors: Li Bowen , Sun Jianping , Wang Shiping , Lv Wangwang , Zhou Yang , Liu Peipei , Wang Qi , A Wang , Zhang Suren , Xia Lu , Hong Huan , Jiang Lili , Luo Caiyun , Zhang Zhenhua , Piao Shilong , Wang Yanfen , Dorji Tsechoe 
Published: June 2022

AbstractThere is a debate about unmatched results between manipulative warming using constant warming rates every year (CW) and long-term observations warming affect temperature sensitivity of flowering phenology. This may be because long-term observations represent the actual yearly increase in temperature (i.e. a yearly stepwise warming rate per year, SW) which would differ from CW and their effects would be regulated by precipitation alteration. We conducted a warming experiment with CW (temperature increase by +1 °C and sustained this elevated temperature for the duration of the study) and SW (temperature increase by + 0.25 °C progressively each year) with precipitation addition in an alpine grassland for four years. Our results showed that neither warming rate affected community flowering phenology. However, precipitation addition advanced onsets of flowering for early-spring flowering (ESF) and mid-summer flowering (MSF) groups, and advanced the end date of flowering for ESF but delayed it for the MSF group. Therefore, flowering duration remained stable for the ESF group and prolonged for the MSF group, and further prolonging the flowering duration of the community. There were no interactions between warming rates and precipitation addition on the community’s flowering phenology. A severe drought in a year significantly decreased the maximal number of community flowers in the following year. Therefore, a change in precipitation has a greater effect than warming on the community flowering phenology in the semi-arid alpine grassland.
Perineal sepsis and successful surgical treatment in supralevator and ischiorectal fossa abscess: a case report
Authors: Charalampopoulos Anestis , Bagias George , Perdicaris Marcos , Latsonas Panagiotis , Papagrigoriadis Savvas , Papaconstantinou Dimitrios 
Published: June 2022

Abstract
A male 61-year-old patient presented to the emergency department with fever, leukocytosis and perineal pain. Macroscopic examination of anogluteal region demonstrated a bulky inflamed mass in the left ischiorectal fossa with a skin defect draining large amounts of pus. The suprapubic area was observed to be erythematous, with local tenderness and a palpable inflammatory mass under the skin. Computed tomography and magnetic resonance imaging revealed an abscess of the ischiorectal fossa and concomitant supralevator abscess. Examination under anesthesia revealed an internal fistula at the posterior dentate line, with pus emanating from the orifice. A bulging mass was found, protruding in the left lateral and inferior area of the rectal ampulla, a finding compatible with the supralevator abscess identified by imaging. Drainage of the abscess into ischiorectal fossa, supralevator space and suprapubic area was successful with a prompt improvement in the clinical and laboratory profile of the patient.
Winter thriving: on the role of a boreal city on bird communities
Authors: MacGregor-Fors Ian 
Published: June 2022

AbstractInformation on how urban areas affect bird communities during winter in the boreal region is still scarce. With the aim of assessing such role of the urban habitats on over-wintering boreal birds, I focused on a city-wide approach in the city of Lahti (southern Finland) and two nearby forests (as controls). Point count surveys were conducted in 157 sites within the city and 30 in the control forests. In order to achieve comparable sets of data to contrast with the reference forests, I randomly selected five 30 point count sub-samples from the Lahti city-wide survey. Species richness was, in general, higher in the sub-samples from the city of Lahti. Such pattern did not show relationship with the built cover of the studied sites. Bird abundances were 3.3–5.9 times higher in the urban sub-samples when contrasted with the forest ones. Although results of this study are limited to a single city and consider one wintering season, they clearly illustrate the important role of urban systems as habitat for wintering birds in boreal systems.
The signature of large-scale turbulence driving on the structure of the interstellar medium
Authors: Colman Tine , Robitaille Jean-François , Hennebelle Patrick , Miville-Deschênes Marc-Antoine , Brucy Noé , Klessen Ralf S , Glover Simon C O , Soler Juan D , Elia Davide , Traficante Alessio , Molinari Sergio , Testi Leonardo 
Published: June 2022

ABSTRACT
The mechanisms that maintain turbulence in the interstellar medium (ISM) are still not identified. This work investigates how we can distinguish between two fundamental driving mechanisms: the accumulated effect of stellar feedback versus the energy injection from galactic scales. We perform a series of numerical simulations describing a stratified star-forming ISM subject to self-consistent stellar feedback. Large-scale external turbulent driving, of various intensities, is added to mimic galactic driving mechanisms. We analyse the resulting column density maps with a technique called Multi-scale non-Gaussian segmentation, which separates the coherent structures and the Gaussian background. This effectively discriminates between the various simulations and is a promising method to understand the ISM structure. In particular, the power spectrum of the coherent structures flattens above 60 pc when turbulence is driven only by stellar feedback. When large-scale driving is applied, the turn-over shifts to larger scales. A systematic comparison with the Large Magellanic Cloud (LMC) is then performed. Only 1 out of 25 regions has a coherent power spectrum that is consistent with the feedback-only simulation. A detailed study of the turn-over scale leads us to conclude that regular stellar feedback is not enough to explain the observed ISM structure on scales larger than 60 pc. Extreme feedback in the form of supergiant shells likely plays an important role but cannot explain all the regions of the LMC. If we assume ISM structure is generated by turbulence, another large-scale driving mechanism is needed to explain the entirety of the observations.
V392 Persei: A γ-ray bright nova eruption from a known dwarf nova
Authors: Murphy-Glaysher F J , Darnley M J , Harvey É J , Newsam A M , Page K L , Starrfield S , Wagner R M , Woodward C E , Terndrup D M , Kafka S , Arranz Heras T , Berardi P , Bertrand E , Biernikowicz R , Boussin C , Boyd D , Buchet Y , Bundas M , Coulter D , Dejean D , Diepvens A , Dvorak S , Edlin J , Eenmae T , Eggenstein H , Fournier R , Garde O , Gout J , Janzen D , Jordanov P , Kiiskinen H , Lane D , Larochelle R , Leadbeater R , Mankel D , Martineau G , Miller I , Modic R , Montier J , Morales Aimar M , Muyllaert E , Naves Nogues R , O’Keeffe D , Oksanen A , Pyatnytskyy M , Rast R , Rodgers B , Rodriguez Perez D , Schorr F , Schwendeman E , Shadick S , Sharpe S , Soldán Alfaro F , Sove T , Stone G , Tordai T , Venne R , Vollmann W , Vrastak M , Wenzel K 
Published: June 2022

ABSTRACT
V392 Persei is a known dwarf nova (DN) that underwent a classical nova eruption in 2018. Here we report ground-based optical, Swift UV and X-ray, and Fermi-LAT γ-ray observations following the eruption for almost three years. V392 Per is one of the fastest evolving novae yet observed, with a t2 decline time of 2 d. Early spectra present evidence for multiple and interacting mass ejections, with the associated shocks driving both the γ-ray and early optical luminosity. V392 Per entered Sun-constraint within days of eruption. Upon exit, the nova had evolved to the nebular phase, and we saw the tail of the supersoft X-ray phase. Subsequent optical emission captured the fading ejecta alongside a persistent narrow line emission spectrum from the accretion disc. Ongoing hard X-ray emission is characteristic of a standing accretion shock in an intermediate polar. Analysis of the optical data reveals an orbital period of 3.230 ± 0.003 d, but we see no evidence for a white dwarf (WD) spin period. The optical and X-ray data suggest a high mass WD, the pre-nova spectral energy distribution (SED) indicates an evolved donor, and the post-nova SED points to a high mass accretion rate. Following eruption, the system has remained in a nova-like high mass transfer state, rather than returning to the pre-nova DN low mass transfer configuration. We suggest that this high state is driven by irradiation of the donor by the nova eruption. In many ways, V392 Per shows similarity to the well-studied nova and DN GK Persei.
SoUthern Cluster sCale Extended Source Survey (SUCCESS): a GMRT and Meerkat study of nine massive galaxy clusters
Authors: Kale R , Parekh V , Rahaman M , Joshi D C , Venturi T , Kolokythas K , Chibueze J O , Sikhosana S , Pillay D , Knowles K 
Published: June 2022

ABSTRACT
We aim to carry out a radio study of the SoUthern Cluster sCale Extended Source Survey (SUCCESS) sample consisting of 20 massive (M500 &gt; 5 × 1014 M⊙), nearby (redshift &lt;0.3) and southern (−50° &lt; δ &lt; −30°) galaxy clusters detected by the Planck satellite and the South Pole Telescope. Here, we report targeted GMRT observations (325/610 MHz) for a subsample of nine clusters. We also use the first data release of MeerKAT Galaxy Cluster Legacy Survey (1283 MHz) for five of these nine clusters. The properties of the mini-halo in RXC J0528.9-3927, a candidate mini-halo in A3322, the radio halo and candidate double relics in A3399, and the radio halo in RXC J0232.2-4420 are presented. We also report a detection of candidate radio relics at distances 1 and 1.9 Mpc from the centre of RXC J0232.2-4420. The southeast relic of A3399 is consistent with the radio power–mass scaling relation for radio relics, while the candidate relics around RXC J0232.2-4420 are outliers. This indicates an origin of the candidate relics near RXC J0232.2-4420 to be independent of this cluster and a cluster merger-shock origin for the relic in A3399. In this subsample of clusters, 1/9 hosts a radio halo and double relics, 1/9 hosts a radio halo and 2/9 host mini-haloes. The dynamical states based on X-ray morphology show that A3399 is a disturbed cluster; however, the radio halo cluster RXC J0232.2-4420 is relaxed, and the mini-halo clusters have intermediate morphologies, adding to the cases of the less commonly found associations.
TOI-2119: a transiting brown dwarf orbiting an active M-dwarf from NASA’s TESS mission
Authors: Carmichael Theron W , Irwin Jonathan M , Murgas Felipe , Pallé Enric , Stassun Keivan G , Bartnik Matthew , Collins Karen A , de Leon Jerome , Esparza-Borges Emma , Fedewa Jeremy , Fong William , Fukui Akihiko , Jenkins Jon M , Kagetani Taiki , Latham David W , Lund Michael B , Mann Andrew W , Moldovan Dan , Morgan Edward H , Narita Norio , Painter Shane , Parviainen Hannu , Quintana Elisa V , Ricker George R , Schulte Jack , Schwarz Richard P , Seager Sara , Sokolovsky Kirill , Twicken Joseph D , Winn Joshua N 
Published: June 2022

ABSTRACT
We report the discovery of TOI-2119b, a transiting brown dwarf (BD) that orbits and is completely eclipsed by an active M-dwarf star. Using light-curve data from the Transiting Exoplanet Survey Satellite mission and follow-up high-resolution Doppler spectroscopic observations, we find the BD has a radius of Rb = 1.08 ± 0.03RJ, a mass of Mb = 64.4 ± 2.3MJ, an orbital period of P = 7.200865 ± 0.00002 d, and an eccentricity of e = 0.337 ± 0.002. The host star has a mass of M⋆ = 0.53 ± 0.02M⊙, a radius of R⋆ = 0.50 ± 0.01R⊙, an effective temperature of Teff = 3621 ± 48K, and a metallicity of $\rm [Fe/H]=+0.06\pm 0.08$. TOI-2119b joins an emerging population of transiting BDs around M-dwarf host stars, with TOI-2119 being the ninth such system. These M-dwarf–brown dwarf systems typically occupy mass ratios near q = Mb/M⋆ ≈ 0.1−0.2, which separates them from the typical mass ratios for systems with transiting substellar objects and giant exoplanets that orbit more massive stars. The nature of the secondary eclipse of the BD by the star enables us to estimate the effective temperature of the substellar object to be 2030 ± 84K, which is consistent with predictions by substellar evolutionary models.