bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education and Information Need for Emergency Physicians About Rare Diseases in China
Authors: Zhou Lingli , Xu Jun , yang jing 
Published: January 2022

Abstract
Background: Rare diseases are serious and chronic disease that affect no more than 1 person in 2000. The patients suffering from RD may come to emergency department for life-threatening symptoms, such as acute aortic dissection, intracranial hemorrhage, and severe respiratory distress. Diagnostic delay of rare disease patients is common and often caused by low rare disease awareness among physicians. The main aim of this study was to investigate the Chinese emergency physicians’ basic knowledge, information access and educational needs regarding rare diseases. An online questionnaire was completed by Chinese emergency physicians during January and March 2021. Methods and Results: A total of 539 emergency physicians responded to the questionnaire-based study, including 200 females and 339 males. More than half of respondents were from Tertiary A hospital and had engaged in medical clinical work more than 10 years. Only 4.27% of respondents correctly estimated the prevalence of rare diseases. A few respondents knew the exact number of RD in the first official list of rare diseases in 2018. 98.5% of respondents rated their knowledge about rare diseases as rare or insufficient. Most of emergency physicians preferred to getting information by search engine instead of specialized websites of rare diseases. Lack of practice guidelines or consensus and were considered as the most important reason for diagnostic delay of RD. Practice guidelines or consensus and professional websites on rare diseases were urgently needed for emergency physicians.Conclusion: The investigation shows poor knowledge of emergency physicians regarding rare diseases. Practice guidelines and professional websites on rare diseases were the prominently urgent needs for emergency physicians. Specialized RD courses should also be added in medical education.
Presentative deictics in Oromo
Authors: Hussien Ahmed Mahmud , Beyene Shimellis Mazengia 
Published: January 2022

Abstract
This study deals with the forms, meanings and functions of presentative deictics in Oromo. Basically, presentatives deictics are deictic expressions that are used in directing the attention of an addressee towards a referent mentioned by a speaker in the communication situation. They are expressed in the use of proximal and distal presentative deictic adverbs, adverbial phrases or determiners. This is a qualitative descriptive study and the data were collected through note-taking of free language use, elicitation, and introspection. The data thus collected were transcribed phonemically using IPA. The data were arranged in interlinear morpheme-by-morpheme basis in three lines following the Leipzig Glossing Rules. The results of the analyses contained lexicalizations of presentative expressions commonly used, (morpho)-syntactc properties of presentatives in different discourse contexts, the exophoric and referential functions of presentatives of which the exophoric function takes into account referents found in the environment where communication is taking place, and the referential functions were concerned with reference to linguistic items in the text. The offerative and the directive functions come under the exophoric use, whereas cataphoric, anaphoric and discourse signal functions come under referential functions. The meanings of the presentative deictics are based on the context in which they are used.
The Hydrogen Storage Nanomaterial MgH2 Improves Irradiation-induced Male Fertility Impairment by Suppressing Oxidative Stress
Authors: Ma Jing , Dong Suhe , Lu Hongtao , Chen Zhongmin , Yu Huijie , Sun Xuejun , Peng Renjun , Li Wei , Wang Sinian , Jiang Qisheng , Li Fengsheng , Ma Li 
Published: January 2022

Abstract
ObjectiveThis study aimed to reveal the protective effect of hydrogen storage nanomaterial MgH2 on radiation-induced male fertility impairment.MethodsThe characterization of MgH2 were analyzed by scanning electron microscopy (SEM) and particle size analyzer. The safety of MgH2 were evaluated in vivo and in vitro. The radioprotective effect of MgH2 on the reproductive system were analyzed in mice, including sperm quality, genetic effect, spermatogenesis, and hormone secretion. ESR, flow cytometry and western blotting assay were used to reveal the underlying mechanisms.ResultsMgH2 had an irregular spherical morphology and a particle size of approximately 463.2 nm, and the content of Mg reached 71.46%. MgH2 was safe and nontoxic in mice and cells. After irradiation, MgH2 treatment significantly protected testicular structure, increased sperm density, improved sperm motility, reduced deformity rates, and reduced the genetic toxicity. Particularly, the sperm motility were consistent with those in MH mice and human semen samples. Furthermore, MgH2 treatment could maintain hormone secretion and testicular spermatogenesis, especially the generation of Sertoli cells, spermatogonia and round sperm cells. In vitro, MgH2 eliminated the [·OH], suppressed the irradiation-induced increase in ROS production, and effectively alleviated the increase in MDA contents. Moreover, MgH2 significantly ameliorated apoptosis in testes and cells and reversed the G2/M phase cell cycle arrest induced by irradiation. In addition, MgH2 inhibited the activation of radiation-induced inflammation and pyroptosis.ConclusionMgH2 improved irradiation-induced male fertility impairment by eliminating hydroxyl free radicals.
Shake Table Tests of a Novel Low-rise Bolt-Assembled Precast Concrete Sandwich Wall Panel Structure
Authors: Xiong Feng , Chen Wen , Ge Qi , Chen Jiang , Lu Yang 
Published: January 2022

Abstract
A novel low-rise bolt - assembled precast concrete sandwich wall panel structure for rural residential houses was proposed, in which the connections between wall and wall, and wall and floor were connected by high strength bolts and steel plates. The bolt joints can be easily installed and disassembled. They are replaceable to make the precast structure demountable and reassembled. All the components are connected together by the novel bolted connectors. This paper presents the shake-table tests of a full-scale two-story bolt-assembled precast concrete sandwich wall building. The results indicated that the proposed structural system had good seismic performance and remained in the elastic stage with no damage after 9-degree rare earthquake excitation for the Model-1. The Model-2 exhibited excellent capacity and performed satisfactorily under the excitation up to 0.8 g. Cracks were observed at the wall openings and the base of walls and columns, which was similar to that of a cast-in-situ structure. The damage statuses were mainly light damage and moderate damage. The bolt connection joints were not anti-seismic weak places and had good seismic performance. Equivalent base shear method is suitable for estimating the seismic demand of the proposed precast concrete sandwich wall panel structure.
Intestinal Flora and Inflammation in Acute Coronary Syndromes
Authors: Ma Huiyan , Yang Libo , Yan Ning , Zhang Hua , Zhang Xiaoxia , Jia Shaobin , Wang Hao 
Published: January 2022

Abstract
Background: Acute coronary syndromes (ACS) is closely associated with chronic low-grade inflammation and gut microbiome composition. However, the composition and functional capacity of the gut microbiome in relation to ACS have not been systematically examined. Results: we perform a metagenome-wide association study on stools and plasma from 66 individuals with ACS and 46 healthy controls (HC). We then compared gut microbial composition using 16S ribosomal RNA gene sequencing in fecal samples to detect species with differential abundance between 2 groups. We reported that the altered composition of gut microbiota was associated with ACS and exacerbated inflammatory status. Moreover, parameters in ACS including body weights (BWs), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), C-reactive protein (CRP) and high homocysteine (HCY) were elevated; whereas high-density lipoprotein (HDL) was decreased. pro-inflammatory interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1(MCP-1) and lipopolysaccaride (LPS) in ACS were increased respectively. The results of 16S rRNA sequencing and analysis displayed that the overall community of gut microbiota in ACS was notably changed mainly through increasing the abundance of Bacteroidetes, Verrucomicrobia, Proteobacteria Parabacteroide, Unidentified_Enterobacteriaceae, Subdoligranulum, Akkermansia, Alistipes, Streptococcus, Paraprevotella as well as decreasing Subdoligranulum, Roseburia, Faecalibacterium, Blautia, Agathobacter, Anaerostipes, Bifidobacterium. Further analysis showed that there was a significant correlation between the above differences in gut microbiota and inflammatory factors. Conclusions: Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACS.
Appraisal of Anti-Arthritic Potential of Quercus Leucotrichophora Methanolic Extract in Complete Freund’s Adjuvant Induced Arthritic Rats; a Mechanistic Study
Authors: Saleem Ammara , Hameed Izza , Akhtar Muhammad Furqan , Rahman Md. Habibur , Ash Ghulam Md 
Published: January 2022

Abstract
This research work was conducted to validate the folkloric use and therapeutic potential of Quercus leucotrichophora (QL) leaf methanolic and aqueous extracts against inflammation and arthritis and to determine the chemical composition by HPLC. The in-vitro anti-oxidant and anti-inflammatory activities were carried out along with in-vivo assays such as carrageenan induced paw edema, xylene induced ear edema and Complete Freund’s Adjuvant induced arthritis in Wistar rats. The CFA (0.1 ml) was inoculated to the left hind paw at day 1 to induce arthritis and oral dosing with QLME at 150, 300 and 600 mg/kg was begun at 8th day till the 28th day in all groups while methotrexate was given as standard treatment. There was a noteworthy (p<0.05-0.0001) restoration in body weight, paw edema, arthritic index, altered blood parameters and oxidative stress biomarkers in treated rats as compared to diseased group. Moreover, QLME considerably (p<0.0001) downregulated TNF-α, IL-6, IL-1β, COX-2, and NF-κB, while significantly (p<0.0001) upregulated IL-10, I-κB, IL-4 in relation to diseased group. The QLME exhibited no mortality in acute toxicity study. It was concluded that QLME possessed substantial anti-inflammatory and anti-arthritic potential at all dosage levels, mainly at 600 mg/kg might be due to presence of quercetin, sinapic acid and ferulic acid.
Withdrawal of Life-Sustaining Therapy in Intensive Care Unit Patients Following Out-Of-Hospital Cardiac Arrest: An Australian Metropolitan ICU Experience
Authors: Devanand Nilesh Anand , Ruknuddeen Mohammed Ishaq , Soar Natalie , Edwards Suzanne 
Published: January 2022

Abstract
Objective: To determine factors associated with withdrawal of life-sustaining therapy (WLST) in intensive care unit (ICU) patients following out-of-hospital cardiac arrest (OHCA).Methods: A retrospective review of ICU data from patient clinical records following OHCA was conducted from January 2010 to December 2015. Demographic features, cardiac arrest characteristics, clinical attributes and targeted temperature management were compared between patients with and without WLST. We dichotomised WLST into early (ICU length of stay <72 hours) and late (ICU length of stay ≥72 hours). Factors independently associated with WLST were determined by multivariable binary logistic regression using a backward elimination method, and results were depicted as odds ratios (OR) with 95% confidence intervals (CI).Results: The study selection criteria resulted in a cohort of 260 ICU patients post-OHCA, with a mean age of 58 years and the majority were males (178, 68%); 151 patients (58%) died, of which 145 (96%) underwent WLST, with the majority undergoing early WLST (89, 61%). Status myoclonus was the strongest independent factor associated with early WLST (OR 38.90, 95% CI 4.55–332.57; p < 0.001). Glasgow Coma Scale (GCS) motor response of <4 on day 3 post-OHCA was the strongest factor associated with delayed WLST (OR 91.59, 95% CI 11.66–719.18; p < 0.0001).Conclusion: The majority of deaths in ICU patients post-OHCA occurred following early WLST. Status myoclonus and a GCS motor response of <4 on day 3 post-OHCA are independently associated with WLST.
Development of an integrating coagulation and reverse osmosis system to treat highly turbid water using synthesized coagulants
Authors: Solanki Yogendra Singh , Agarwal Madhu , Gupta A. B. 
Published: January 2022

Abstract
In the present study a coagulation process was used as a pretreatment for a reverse osmosis (RO) membrane with turbid raw water collected from Bisalpur dam, Rajasthan, India. To optimize the coagulation performance, three kinds of coagulant, namely, alum (commercially available), synthesized inorganic polymeric coagulant-medium basicity (IPC-M), and inorganic polymeric coagulant-ultrahigh basicity (IPC-UH) were examined for turbidity removal with varying operating parameters. It was observed that in the optimum pH range of 6–7, the IPC-UH was the best performing coagulant with a 0.99 mg/L equivalent Al2O3 dose, revealing 2 NTU residual turbidity and residual aluminium of 0.001 mg/L. Moreover, the Langelier saturation index and Ryznar stability index values were evaluated at optimum conditions for all the three coagulants providing negligible scaling potential. Furthermore, the coagulant-treated water (100 L) was fed to the RO membrane, and the performance was noted in terms of flux, pressure, and total dissolved solids. It was observed that IPC-UH had the lowest reduction in permeate flux of 0.78 L/min/m2 compared with the commercially available coagulant alum (0.90 L/min/m2). Also, an increased feed pressure was observed for all the coagulant-treated waters with the lowest value of 2.3 kg/cm2 for IPC-UH, which was 2.5 kg/cm2 for alum (commercially available coagulant). Therefore, integration of coagulation before the RO system resulted in effective pretreatment of turbid water with very minute scaling.
Clima organizacional y satisfacción laboral de las enfermeras de un centro quirúrgico de EsSalud, Lima 2017
Authors: De la Cruz Pérez Lisset Ruth , Ramírez Miranda Edna 
Published: January 2022

Objetivo: Determinar la relación entre el clima organizacional y la satisfacción laboral de las enfermeras en un centro quirúrgico de EsSalud, Lima 2017. Materiales y métodos: Estudio con enfoque cuantitativo, diseño tipo descriptivo correlacional y transversal, nivel aplicativo. Se encuestó a 75 enfermeras que laboran en el Centro Quirúrgico, muestra no probabilística por conveniencia; Se empleó como técnica la entrevista y como instrumentos dos cuestionarios correspondientes a las variables involucradas, evaluados exitosamente en base los indicadores de confiabilidad y validez; aplicados con previo consentimiento informado. La correlación se determinó mediante la correlación de RHO DE SPEARMAN. Resultados: Se obtuvo un coeficiente de correlación de 0,708 entre ambas variables, lo cual indica una elevada correlación entre las variables, además, significativa al 99%; donde se observa en el clima organizacional que, un 25,3% (n=19) de participantes presentan un deterioro en la comunicación y en la satisfacción laboral un 21,3% (n=16) de los participantes están insatisfechos en el desempeño de tareas. Conclusión: Existe relación estadísticamente significativa entre el clima organizacional y la satisfacción laboral de las enfermeras. El centro quirúrgico de los hospitales deben ser espacios de trabajo donde el clima organizacional y la satisfacción laboral sean positivos para las enfermeras.
The Interaction of Dynamic Cerebral Autoregulation and Neurovascular
Coupling in Cognitive Impairment
Authors: Beishon Lucy C. , Intharakham Kannakorn , Haunton Victoria J. , Robinson Thompson G. , Panerai Ronney B. 
Published: January 2022

Background:
Dynamic cerebral autoregulation (dCA) remains intact in both ageing and
dementia, but studies of neurovascular coupling (NVC) have produced mixed findings.

Objective:
We investigated the effects of task-activation on dCA in healthy older adults (HOA),
and patients with mild cognitive impairment (MCI) and Alzheimer’s Disease (AD).

Methods:
Resting and task-activated data from thirty HOA, twenty-two MCI, and thirty-four AD
were extracted from a database. The autoregulation index (ARI) was determined at rest and during
five cognitive tasks from transfer function analysis. NVC responses were present where group-specific
thresholds of cross-correlation peak function and variance ratio were exceeded. Cumulative response
rate (CRR) was the total number of positive responses across five tasks and two hemispheres.

Results:
ARI differed between groups in dominant (p=0.012) and non-dominant (p=0.042) hemispheres
at rest but not during task-activation (p=0.33). ARI decreased during language and memory
tasks in HOA (p=0.002) but not in MCI or AD (p=0.40). There was a significant positive correlation
between baseline ARI and CRR in all groups (r=0.26, p=0.018), but not within sub-groups.

Conclusion:
dCA efficiency was reduced in task-activation in healthy but not cognitively impaired
participants. These results indicate differences in neurovascular processing in healthy older adults
relative to cognitively impaired individuals.
Blood Pressure Responses in Firefighters: A Review
Authors: Feairheller Deborah L , McMorrow Carly 
Published: January 2022

Abstract:
Blood pressure (BP) responses are controlled by various factors and understanding how
BP changes is important to occupational health. This paper presents a review of the literature that
reports BP responses in the firefighter population. Hypertension is one of the main risk factors underlying
the pathophysiology of cardiovascular disease (CVD), and cardiac incidents remain the
leading cause of line-of-duty deaths in firefighters. Risk factors for line-of-duty deaths include obesity,
previous or underlying heart disease, and hypertension. The occupation of firefighting is one
of the most hazardous and dangerous jobs, yet over 50 % of firefighters are volunteers. Tactical operations
and the hazardous nature of firefighting are exposures that influence stress responses and,
therefore, affect BP. In fact, hypertension in firefighters often remains undocumented or undiagnosed.
CVD risk and elevated BP in tactical populations, like firefighters, maybe a combination of
physical and emotional stress due to the nature of the job. Cross-sectional studies have reported
that firefighters have higher levels of BP and higher rates of hypertension compared to civilians. Interestingly,
there is a limited amount of research that reports BP values before and after firefighting-
related activities, and very few studies on interventional changes in BP. Here, we synthesize
the literature on firefighting and provide a summary of the studies that report pre- and post- BP levels
that relate to CVD risk factors, occupational factors, firefighting activities, and the data on exercise
training and BP. More studies are needed that examine BP in firefighters and report on the
changes in BP with occupational activities.
Recent Patents on Petroleum Pipe Inspection Gauge in China
Authors: Chen Zhong , Qiu Xiaoyang , Yang Lingling , Wang Yalin 
Published: January 2022

Background:
As the demand for petroleum products grows, pipes to carry these products
are also required extensively. Consequently, petroleum pipe blockage has become a frequent and
severe problem in China. In order to ensure trouble-free operation, it is necessary to clean and inspect
the petroleum pipe regularly. However, currently available petroleum pipe inspection gauges
can block the petroleum pipe easily, and their cleaning efficiency is not as high as desired. Therefore,
mechanisms to prevent pipe blockage and ensure high-efficiency cleaning are being given
much importance in studies on petroleum pipe inspection gauges.

Objective:
The aim of the study is to review recent patents related to petroleum pipe inspection
gauges in China and forecast possible designs that can mitigate present-day problems associated
with petroleum pipe inspection gauges.

Methods:
This paper has studied and compared various representative patents relevant to the petroleum
pipe inspection gauge.

Results:
A large number of patents filed in China related to petroleum pipe inspection gauges have
been studied and the anti-blocking mechanism as well as the cleaning efficiency of the petroleum
pipe inspection gauges described in those patents have been analyzed and compared. Forecasts were
made regarding the possible development trajectories in the design of petroleum pipe inspection
gauges.

Conclusion:
The problems of easy blockage and poor cleaning efficiency are yet unsolved for petroleum
pipe inspection gauges. It is expected that future work will focus on the development of
pigging, new materials, power sources, and intelligent control to resolve these issues.
China’s Assertiveness in the South and East China Sea: A Constructivist Approach
Authors: Llanos Antczak Anna , Phommachanh Pathummaly 
Published: January 2022

<p><strong>La asertividad de China en los Mares del Sur y del Este de China: acercamiento constructivista</strong></p><p><strong>Abstract</strong></p><p>This article aims to discuss the issue of China’s assertiveness in the South and East China Seas within the constrictivist framework, as economic (liberalism) and military power (realism) are not sufficient to explain the complexity of the problem.<strong> </strong>It aims to answer the following question: How does the constructivist approach lend itself to the understanding of China’s assertiveness in the case of the South and the East China Sea territorial disputes? It will also explore the following hypotheses: the victimized identity perception leads China to be assertive in the South China Sea dispute and the perception of Japan’s behavior as aggressive (as in the past) provokes China to be assertive in the East China Sea dispute.</p><p><strong>Resumen</strong></p><p><strong></strong>El presente artículo tiene como objetivo discutir la cuestión de la asertividad de China en Los Mares del Sur y del Este de China dentro del marco constrictivista, ya que el poder económico (liberalismo) y el poder militar (realismo) no son suficientes para explicar la complejidad del problema. Tiene como objetivo responder a la siguiente pregunta: ¿Cómo se presta el enfoque constructivista a la comprensión de la asertividad de China en el caso de las disputas territoriales del Mar del Este y del Sur de China? También explorará las siguientes hipótesis: la percepción de la identidad victimizada lleva a China a ser asertiva en la disputa del Mar del Sur de China y la percepción de agresividad en el comportamiento de Japón (como en el pasado) provoca que China sea asertiva en la disputa del Mar del Este de China.</p><p> </p>