bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early development of treatment motivation predicts adherence and symptom reduction in an internet-based guided self-help program for binge eating disorder
Authors: Runge Eik , Jensen Esben Kjems , Mathiasen Kim , Larsen Pia Veldt , Hertz Søren Peter Thygesen , Holmberg Trine Theresa , Tarp Kristine , Linnet Jakob , Lichtenstein Mia Beck 
Published: October 2022

ObjectiveLack of motivation is widely acknowledged as a significant factor in treatment discontinuity and poor treatment outcomes in eating disorders. Treatment adherence is lower in internet-based treatment. The current study aimed to assess the relationship between treatment motivation and treatment outcomes in an internet-based therapist-guided intervention for Binge Eating Disorder (BED).MethodAdults (N = 153) with mild to moderate symptoms of BED participated in a 10-session internet-based treatment program. Baseline and between-session scores of “Readiness to change” and “Belief in change” were used to predict treatment completion and eating disorder symptom reduction (EDE-Q Global, BED-Q, and weekly number of binge eating episodes) at post-treatment.ResultsBaseline treatment motivation could not predict treatment completion or symptom reduction. Early measures of treatment motivation (regression slope from sessions 1–5) significantly predicted both treatment completion and post-treatment symptom reduction. “Belief in change” was the strongest predictor for completing treatment (OR = 2.18, 95%-CI: 1.06, 4.46) and reducing symptoms (EDE-Q Global: B = −0.53, p = 0.001; number of weekly binge eating episodes: B = 0.81, p &lt; 0.01).DiscussionThe results indicated that patients entering online treatment for BED feel highly motivated. However, baseline treatment motivation could not significantly predict treatment completion, which contradicts previous research. The significant predictive ability of early measures of treatment motivation supports the clinical relevance of monitoring the development of early changes to tailor and optimize individual patient care. Further research is needed to examine treatment motivation in regard to internet-based treatment for BED with more validated measures.
Mental burden among Chinese undergraduate medical students: A prospective longitudinal study before, during, and after the COVID-19 outbreak
Authors: Liao Xiao , Zhang Simai , Wang Yue , Jiang Jingwen , Li Yuchen , Zhang Wei 
Published: October 2022

BackgroundIncreasing evidence indicated a clear association between COVID-19 pandemic and mental health. This study aimed to assess the dynamic change of mental burden during and after the COVID-19 outbreak and related predictive factors among Chinese undergraduate medical students.MethodsThis longitudinal survey was conducted among Chinese undergraduate medical students before, during, and after the COVID-19 outbreak. We focused on COVID-19 related mental burdens including psychological distress, stress reaction, and insomnia symptoms, and defined the sum score of the three specific mental burden indexes as the overall mental burden index. The prevalence of specific and overall mental burdens and their changing patterns at two phases of the pandemic (during vs. after the COVID-19 outbreak) were measured. In addition, multinomial logistic regressions were used to assess the associations between the psychosocial status before the pandemic and specific and overall mental burden changing patterns.ResultsOur findings showed that the prevalence of overall mental burden increased (from 27.46 to 37.28%) after the COVID-19 outbreak among the 863 Chinese undergraduate medical students who participated in the surveys at baseline, during, and after the COVID-19 outbreak. Specifically, the prevalence of stress reaction symptoms decreased (from 10.90 to 3.60%), while the rates of psychological distress (from 28.06 to 37.95%) and insomnia symptoms (from 12.54 to 20.71%) increased. Participants, with obsessive-compulsive symptoms, somatic symptoms, internet addiction, childhood adversity, stressful life events, and being neurotic were found to have a higher risk of developing mental burden in at least one survey (during or after the COVID-19 outbreak). Healthy family function and being extravert were found to positively impact mental burden.ConclusionPsychological distress, stress reaction and insomnia symptoms have been prevalent among Chinese undergraduate medical students during the COVID-19 outbreak, and the prevalence of overall mental burden increased after the COVID-19 outbreak. Some students, especially those with the risk factors noted above, exhibited persistent or progression symptoms. Continued mental health care was in demand for them even after the COVID-19 outbreak.
Trends in general and abdominal obesity in US adults: Evidence from the National Health and Nutrition Examination Survey (2001–2018)
Authors: Sun Jin-Yu , Huang Wen-Jun , Hua Yang , Qu Qiang , Cheng Chen , Liu Heng-Li , Kong Xiang-Qing , Ma Yong-Xiang , Sun Wei 
Published: October 2022

AimThis study investigates the trend in general obesity and abdominal obesity in US adults from 2001 to 2018.MethodsWe included 44,184 adults from the nine cycles of the continuous NHANES (2001–2002, 2003–2004, 2005–2006, 2007–2008, 2009–2010, 2011–2012, 2013–2014, 2015–2016, and 2017–2018). The age-adjusted mean body mass index and waist circumference were calculated, and the sex-specific annual change was estimated by the survey cycle. We used the weighted sex-specific logistic regression models to analyze the prevalence of general obesity and abdominal obesity from 2001 to 2018. The weighted adjusted odds ratio (OR) with a 95% confidence interval (CI) was calculated.ResultsOur study showed that general obesity and abdominal obesity account for about 35.48 and 53.13% of the US population. From 2001–2002 to 2017–2018, the age-adjusted prevalence of general obesity increased from 33.09 to 41.36% in females and from 26.88 to 42.43% in males. During 2001–2018, the age-adjusted prevalence of abdominal obesity increased from 57.58 to 67.33% in females and from 39.07 to 49.73% in males. A significant time-dependent increase was observed in the prevalence of general obesity (adjusted OR, 1.007; 95% CI 1.005–1.009, P &lt; 0.001) and abdominal obesity (adjusted OR, 1.006; 95% CI, 1.004–1.008; P &lt; 0.001).ConclusionGeneral obesity and abdominal obesity are a heavy health burden among US adults, and the increasing trend remains in both males and females from 2001 to 2018.
Sustainable return to work after depression - A comparative study among occupational physicians and affected employees
Authors: Ersel Richard Paulinus , Pauli Roman , Gaum Petra Maria , Lang Jessica 
Published: October 2022

IntroductionThe number of sick days taken from work due to depression is steadily rising. A successful return to work (RTW) is essential for sustainable reintegration. This study aims to identify factors to optimize RTW and to investigate approaches for sustainable RTW (sRTW) after depressive episodes.MethodsSemi-structured expert interviews with senior occupational physicians (OPs, N = 5) served to develop two surveys among OPs (N = 180) and employees after depressive episode (N = 192). Predictors of RTW rating, workplace-based RTW interventions and sRTW interventions were analyzed using multiple hierarchical regression, chi-square difference and t-tests.ResultsFor OPs, employee training on mental illness prevention was found to be the strongest predictor of overall RTW rating, whereas understanding and appreciation in conversations and stigmatization were strongest predictors of overall RTW rating by the employees. Compared to the employees, OPs reported significantly more availability of workplace-based interventions. To prevent relapse, the employees prioritized sufficient time and financial security during the RTW process more than OPs.ConclusionsThe study identified facilitating and hindering factors that can inform further research and practice to improve RTW after depressive episodes. To redress the awareness gap about the availability of workplace-based interventions, regular contact between OPs and employees is crucial. Several factors were considered to be of varying importance for relapse prevention by the two groups. Multiple perceptions and needs ought to be taken into account during RTW.
Pandemic intake questionnaire to improve quality, effectiveness, and efficiency of outpatient neurologic and developmental care at the Kennedy Krieger institute during the COVID-19 pandemic
Authors: Vedmurthy Pooja , Murray Connor , Chen Belinda , Asiedu Akua , Baranano Kristin , Bay Mihee , Belcher Harolyn , Burton Vera , Conlon Charles , Fine Amena , Gill Ryan , Harris Jacqueline , Hart Khaylynn , Inches Shannon , Johnson Jennifer , Lance Eboni , Lipkin Paul H. , Menon Deepa U. , McIntyre Tiffany , Rajaprakash Meghna , Recio Albert , Singer Harvey S. , Smegal Lindsay , Smith-Hicks Constance L. , Vernon Hilary , Wilms Floet Anna Maria , Wong Joyce , Yelin Karina , Leppert Mary L. O’Connor , Zabel T. Andrew , Comi Anne M. 
Published: October 2022

BackgroundThe COVID-19 pandemic uniquely affects patients with neurologic and developmental disabilities at the Kennedy Krieger Institute. These patients are at increased risk of co-morbidities, increasing their risk of contracting COVID-19. Disruptions in their home and school routines, and restrictions accessing crucial healthcare services has had a significant impact.MethodsA Pandemic Intake questionnaire regarding COVID-19 related medical concerns of guardians of patients was distributed using Qualtrics. Data from May-December 2020 were merged with demographic information of patients from 10 clinics (Center for Autism and Related Disorders (CARD), Neurology, Epigenetics, Neurogenetics, Center for Development and Learning (CDL) Sickle Cell, Spinal Cord, Sturge-Weber syndrome (SWS), Tourette's, and Metabolism). A provider feedback survey was distributed to program directors to assess the effectiveness of this intervention.ResultsAnalysis included responses from 1643 guardians of pediatric patients (mean age 9.5 years, range 0–21.6 years). Guardians of patients in more medically complicated clinics reported perceived increased risk of COVID-19 (p &lt; 0.001) and inability to obtain therapies (p &lt; 0.001) and surgeries (p &lt; 0.001). Guardian responses from CARD had increased reports of worsening behavior (p = 0.01). Providers increased availability of in-person and virtual therapies and visits and made referrals for additional care to address this. In a survey of medical providers, five out of six program directors who received the responses to this survey found this questionnaire helpful in caring for their patients.ConclusionThis quality improvement project successfully implemented a pre-visit questionnaire to quickly assess areas of impact of COVID-19 on patients with neurodevelopmental disorders. During the pandemic, results identified several major areas of impact, including patient populations at increased risk for behavioral changes, sleep and/or disruptions of medical care. Most program directors reported improved patient care as a result.
A modified trajectory of kyphoplasty via superior pedicle notch for osteoporotic vertebral compression fractures: Technique note and clinical result
Authors: Jiang Yi , Li Jian , Yuan Shuai , Zuo Rujun , Liu Chang , Zhang Jiexun , Ma Ming 
Published: October 2022

BackgroundPercutaneous extra-pedicular kyphoplasty can achieve better clinical results than transpedicular kyphoplasty. However, lumbar segment artery injury as a disaster complication limits its clinical application.ObjectiveTo describe and evaluate a modified trajectory of kyphoplasty for the treatment of osteoporotic vertebral compression fractures (OVCF).MethodsEighty-one patients who underwent percutaneous kyphoplasty (PKP) for lumbar OVCF at our hospital between May 2017 and May 2021 were enrolled. The patients were divided into an observation group (via the superior pedicle approach) and a control group (via the transpedicular approach) according to the surgical trajectory. The surgical procedure was described in detail, and the imaging parameters were recorded. Preoperative and postoperative clinical data were collected for statistical analysis.ResultsPKP via the superior pedicle notch approach could offer large abduction and cranial inclination angles without serious complications. The rate of paravertebral leakage was significantly lower in the observation group than in the control group. Surgery with a superior pedicle notch approach had a shorter operative time and fewer fluoroscopies.ConclusionsPKP via the superior pedicle notch approach is a modified extra-pedicular approach for lumbar osteoporotic vertebral compression fractures. This trajectory is an easy-to-use target position because it enters the vertebral body directly. A shorter operative time and lower radiation exposure can enhance recovery after surgery.
Effect of new-style anterior and posterior vaginal wall repair combined with modified ischial spine fascia fixation on patients with pelvic organ prolapse and their postoperative quality of life
Authors: Wang Gensheng , Zhou Shengju , Wang Shuhua , Xu Dongdi , Wang Dan , Xu Hongling , Gao Chuanlong , Li Qing 
Published: October 2022

ObjectiveThis study aims to explore the effect of new-style anterior and posterior vaginal wall repair combined with modified ischial spine fascia fixation on patients with pelvic organ prolapse (POP) and their postoperative quality of life.MethodsA total of 88 patients with POP and elective surgery admitted to Anqing Hospital affiliated to Anhui Medical University from March 2018 to March 2021 were retrospectively analyzed. According to their surgical methods, patients were divided into an observation group [44 cases, all underwent new-style anterior and posterior vaginal wall repair combined with modified ischial spine fascia fixation (new-style APVR-modified ISFF)] and a control group [44 cases, all underwent traditional anterior and posterior vaginal wall repair combined with sacrospinous ligament fixation (traditional APVR- SLF)]. The perioperative indicators were compared between the two groups. The pelvic floor function, pelvic organ prolapse quantification (POP-Q) classification, and quality of life were observed before operation, 3 months after operation, and 6 months after operation. All patients were followed-up.ResultsCompared with the control group, the observation group had more advantages in intraoperative blood loss, operation time, urinary catheter indwelling time, postoperative anal exhaust time, and hospitalization time (P &lt; 0.05). In terms of pelvic floor function, patients of both groups showed significant improvement at 3 months and 6 months after surgery (P &lt; 0.05). In terms of quality of life, the two groups exhibited significant improvement at 6 months after surgery (P &lt; 0.05). PFIQ-7, PFDI-20, and UDI-6P of the observational group were lower than those of the control group, while PISQ-12 was higher than that of the control group but all with no significant difference (P &gt; 0.005). In addition, the total complication rate of the observation group was 2.27% (1/44), which was significantly lower than 22.73% (10/44) of the control group (P &lt; 0.05).ConclusionNew-style APVR-modified ISFF can effectively treat POP and improve the quality of life of such patients, with less postoperative complications and high safety.
Novel color M-mode echocardiography for non-invasive assessment of the intraventricular pressure in goats: Feasibility, repeatability, and the effect of sedation
Authors: Mandour Ahmed S. , Samir Haney , Yoshida Tomohiko , Matsuura Katsuhiro , Hamabe Lina , Shimada Kazumi , Abdelmageed Hend A. , Elbadawy Mohamed , Uemura Akiko , Takahashi Ken , Watanabe Gen , Tanaka Ryou 
Published: October 2022

BackgroundThe intraventricular pressure difference (IVPD) and intraventricular pressure gradients (IVPG), estimated from color M-mode echocardiography (CMME) of the transmitral flow, have been introduced as novel indices for the evaluation of heart functions. Until now, no study demonstrated the feasibility of the CMME approach to measure IVPD and IVPG in any farm animals. The aim of this study was to assess the feasibility and repeatability of CMME-derived IVPD and IVPG variables in goats and explore the effect of sedation on the measured variables.Materials and methodsSixteen male Shiba goats were included in this study and underwent conventional echocardiography. Eight goats were used in the repeatability of IVPD/IVPG variables. Another eight goats were used to evaluate the effect of sedation by xylazine on IVPD/IVPG measurements. CMME between the base and the apex of the left ventricle was carried out. The IVPD and IVPG were analyzed using in-house code software. The IVPD and IVPG were expressed as total, basal, mid-to-apical, mid, and apical segments. Data analysis including the imaging quality score (IQS), repeatability, variability, intraclass correlation coefficient (ICC), as well as the effect size of sedation on the measured variables was calculated.ResultsIVPD and IVPG variables from CMME were feasible in all goats. Low to moderate variability of IVPD and IVPG variables was observed (CV 95% &lt;25%) except for the apical IVPD and apical IVPG. The IVPD/IVPG measurements were repeatable without a significant effect of animal or time on the obtained measurements. The overall ICC was higher than 0.75 in all variables except for the apical segment. Xylazine administration reduced the total, basal, and mid parts of IVPD and IVPG with a large effect size (biserial ranked correlation; rc &gt; 0.8).ConclusionWe reported, for the first time, IVPD and IVPG measurements by CMME in goats. The assessment of IVPD and IVPG by CMME is feasible in goats which can be evaluated in further cardiovascular or pharmacological studies in this species.
Overexpression of Dehydrogenase/Reductase 9 Predicts Poor Response to Concurrent Chemoradiotherapy and Poor Prognosis in Rectal Cancer Patients
Authors: Chen Tzu-Ju , Hsu Bei-Hao , Lee Sung-Wei , Yang Ching-Chieh , Tian Yu-Feng , Kuo Yu-Hsuan , Li Wan-Shan , Tsai Hsin-Hwa , Wu Li-Ching , Yeh Cheng-Fa , Chou Chia-Lin , Lai Hong-Yue 
Published: October 2022

Objective: To reduce the risk of locoregional recurrence, the addition of neoadjuvant concurrent chemoradiotherapy (CCRT) is recommended before surgical management for rectal cancer patients. However, despite identical tumor histology, individual patient response to neoadjuvant CCRT varies greatly. Accordingly, a comprehensive molecular characterization that is used to predict CCRT efficacy is instantly needed.Methods: Pearson’s chi-squared test was utilized to correlate dehydrogenase/reductase 9 (DHRS9) expression with clinicopathological features. Survival curves were created applying the Kaplan-Meier method, and the log-rank test was conducted to compare prognostic utility between high and low DHRS9 expression groups. Multivariate Cox proportional hazards regression analysis was applied to identify independent prognostic biomarkers based on variables with prognostic utility at the univariate level.Results: Utilizing a public transcriptome dataset, we identified that the DHRS9 gene is the most considerably upregulated gene related to epithelial cell differentiation (GO: 0030855) among rectal cancer patients with CCRT resistance. Employing immunohistochemical staining, we also demonstrated that high DHRS9 immunoexpression is considerably associated with an aggressive clinical course and CCRT resistance in our rectal cancer cohort. Among all variables with prognostic utility at the univariate level, only high DHRS9 immunoexpression was independently unfavorably prognostic of all three endpoints (all p ≤ 0.048) in the multivariate analysis. In addition, applying bioinformatic analysis, we also linked DHRS9 with unrevealed functions, such as keratan sulfate and mucin synthesis which may be implicated in CCRT resistance.Conclusion: Altogether, DHRS9 expression may serve as a helpful predictive and prognostic biomarker and assist decision-making for rectal cancer patients who underwent neoadjuvant CCRT.
Penerapan E-Learning Terhadap Tingkat Pemahaman Membaca Teks Berbahasa Inggris dengan Tema Teknologi Pada Mahasiswa STMIK Palangkaraya
Authors: Norhayati  , Putra Christia , Elmayantie Catharina 
Published: October 2022

Penerapan e-learning telah menjadi hal yang lumrah pada masa sekarang ini. Ditambah lagi dalam keadaan pandemi seperti saat ini, dimana pembelajaran tatap muka dilakukan secara daring melalui berbagai platform aplikasi. Dalam penelitian ini, penulis melakukan evaluasi terhadap hasil dari penerapan e-learning bagi mahasiswa pada perguruan tinggi, terutama pada STMIK Palangkaraya. Variabel utama yang akan dievaluasi adalah pengaruh dari penerapan e-learning terhadap tingkat pemahaman teks berbahasa Inggris bagi mahasiswa STMIK Palangkaraya. Metode penelitian yang digunakan adalah desriptif kuantitatif. Dari hasil penelitian ini diketahui bahwa; 1) Kebiasaan membaca mahasiswa STMIK Palangkaraya cukup baik namun masih perlu ditingkatkan lagi; 2) Mahasiswa memiliki tingkat pemahaman yang baik saat mengerjakan tes reading comprehension secara konvensional; dan 3) Rendahnya skor saat mengerjakan tes menggunakan google assessment dikarenakan beberapa factor, diantaranya: tersedia pilihan jawaban dalam bentuk multiple choice, sehingga sebagian besar (60 %) mahasiswa hanya menebak dalam memberikan jawaban; tampilan google assessment untuk teks yang panjang kurang nyaman bagi mahasiswa saat membaca dan kendala teknis terkait jaringan yang kurang stabil saat mengerjakan assessment.
Understanding a Single-Li-Ion COF Conductor for Being Dendrite Free in a Li-Organic Battery
Authors: Sun Yongjiang , Zhao Genfu , Fu Yao , Yang Yongxin , Zhang Conghui , An Qi , Guo Hong 
Published: October 2022

In addition to improving ion conductivity and the transference number, single-Li-ion conductors (SLCs) also enable the elimination of interfacial side reactions and concentration difference polarization. Therefore, the SLCs can achieve high performance in solid-state batteries with Li metal as anode and organic molecule as cathode. Covalent organic frameworks (COFs) are leading candidates for constructing SLCs because of the excellent 1D channels and accurate chemical-modification skeleton. Herein, various contents of lithium-sulfonated covalently anchored COFs (denoted as LiO
3
S-COF1 and LiO
3
S-COF2) are controllably synthesized as SLCs. Due to the directional ion channels, high Li contents, and single-ion frameworks, LiO
3
S-COF2 shows exceptional Li-ion conductivity of

5.47
×

10

−
5

S
·
c

m

−
1

, high transference number of 0.93, and low activation energy of 0.15 eV at room temperature. Such preeminent Li-ion-transported properties of LiO
3
S-COF2 permit stable Li
+
plating/stripping in a symmetric lithium metal battery, effectively impeding the Li dendrite growth in a liquid cell. Moreover, the designed quasi-solid-state cell (organic anthraquinone (AQ) as cathode, Li metal as anode, and LiO
3
S-COF2 as electrolyte) shows high-capacity retention and rate behavior. Consequently, LiO
3
S-COF2 implies a potential value restraining the dissolution of small organic molecules and Li dendrite growth.