bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic T1-Time Predicts Cardiovascular Risk in All-Comers Referred for Cardiovascular Magnetic Resonance: A Post-Hoc Analysis
Authors: Mascherbauer Katharina , Donà Carolina , Koschutnik Matthias , Dannenberg Varius , Nitsche Christian , Duca Franz , Heitzinger Gregor , Halavina Kseniya , Steinacher Eva , Kronberger Christina , Bardach Constanze , Beitzke Dietrich , Loewe Christian , Waldmann Elisabeth , Trauner Michael , Bartko Philipp , Goliasch Georg , Mascherbauer Julia , Hengstenberg Christian , Kammerlander Andreas 
Published: October 2022

Background:
Liver damage is frequently observed in patients with cardiovascular disease but infrequently quantified. We hypothesized that in patients with cardiovascular disease undergoing cardiac magnetic resonance, liver T1-times indicate liver damage and are associated with cardiovascular outcome.

Methods:
We measured hepatic T1-times, displayed on standard cardiac T1-maps, in an all-comer cardiac magnetic resonance-cohort. At the time of cardiac magnetic resonance, we assessed validated general liver fibrosis scores. Kaplan-Meier estimates and Cox-regression models were used to investigate the association between hepatic T1-times and a composite endpoint of non-fatal myocardial infarction, heart failure hospitalization, and death.

Results:

One thousand seventy-five participants (58±18 year old, 47% female) were included (972 patients, 50 controls, 53 participants with transient elastography). Hepatic T1-times were 590±89 ms in patients and 574±45 ms in controls (
P
=0.052). They were significantly correlated with cardiac size and function, presence of atrial fibrillation, NT-pro-BNP levels, and gamma-glutamyl-transferase levels (
P
<0.001 for all). During follow-up (58±31 months), a total of 280 (29%) events occurred. On Cox-regression, high hepatic T1-times yielded a significantly higher risk for events (adjusted hazard ratio, 1.66 [95% CI, 1.45–1.89] per 100 ms increase;
P
<0.001), even when adjusted for age, sex, left and right ventricular ejection fraction, NT-proBNP (N-terminal prohormone of brain natriuretic peptide), and myocardial T1-time. On receiver operating characteristic analysis and restricted cubic splines, we found that a hepatic T1-time exceeding 610 ms was associated with excessive risk.

Conclusions:
Hepatic T1-times on standard cardiac magnetic resonance scans were significantly associated with cardiac size and function, comorbidities, natriuretic peptides, and independently predicted cardiovascular mortality and morbidity. A hepatic T1-time >610 ms seems to indicate excessive risk.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04220450.
Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome and High Bleeding Risk
Authors: Lahu Shqipdona , Presch Antonia , Ndrepepa Gjin , Menichelli Maurizio , Valina Christian , Hemetsberger Rayyan , Witzenbichler Bernhard , Bernlochner Isabell , Joner Michael , Xhepa Erion , Hapfelmeier Alexander , Kufner Sebastian , Rifatov Nonglag , Sager Hendrik B. , Mayer Katharina , Kessler Thorsten , Laugwitz Karl-Ludwig , Richardt Gert , Schunkert Heribert , Neumann Franz-Josef , Sibbing Dirk , Angiolillo Dominick J. , Kastrati Adnan , Cassese Salvatore 
Published: October 2022

Background:

The relative efficacy and safety of more potent P2Y
12
inhibitors in patients with acute coronary syndrome and high bleeding risk (HBR) undergoing percutaneous coronary intervention remains unclear. We aimed to study the treatment effect of ticagrelor and prasugrel in percutaneous coronary intervention patients presenting with acute coronary syndrome and HBR.

Methods:
This post hoc analysis of the ISAR-REACT 5 trial (Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5) included patients with acute coronary syndrome undergoing percutaneous coronary intervention, randomized to ticagrelor or prasugrel, in whom HBR was defined as per Academic Research Consortium criteria. The primary (efficacy) end point was the composite of all-cause death, myocardial infarction, or stroke. The secondary (safety) end point was Bleeding Academic Research Consortium type 3 to 5 bleeding. Outcomes were assessed 12 months after randomization.

Results:

Out of the 3239 patients included in this analysis, 486 fulfilled the criteria for Academic Research Consortium-HBR definition (HBR group; ticagrelor, n=230 and prasugrel, n=256), while 2753 did not (non-HBR group; ticagrelor, n=1375 and prasugrel, n=1378). Compared with the non-HBR group, the HBR group had a higher risk for the primary (hazard ratio [HR]=3.57 [95% CI, 2.79–4.57];
P
<0.001) and secondary end point (HR=2.94 [2.17–3.99];
P
<0.001). In the HBR group, the primary (HR=1.09 [0.73–1.62]) and secondary (HR=1.18 [0.67–2.08]) end points were not significantly different between patients assigned to ticagrelor and prasugrel. In the non-HBR group, the primary end point (HR=1.62 [1.19–2.20]) occurred more frequently in patients assigned to ticagrelor as compared to patients assigned to prasugrel, without difference in safety (HR=1.08 [0.74–1.58]). There was no significant treatment allocation-by-HBR status interaction with respect to the primary (
P
for interaction=0.12) or secondary (
P
for interaction=0.80) end points.

Conclusions:
In patients with acute coronary syndrome undergoing percutaneous coronary intervention, HBR status increased both ischemic and bleeding risk without significant impact on the relative efficacy and safety of either ticagrelor or prasugrel. These results warrant confirmation in larger cohorts.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01944800.
Mapping the Printing of Sino-European Intercultural Books in China (1582–c.1823)
Authors: Standaert Nicolas , Van den Bosch Nora 
Published: October 2022

Abstract
This article focusses on the production of Sino-European intercultural books in China from the late Ming until the mid-Qing (1582–c.1823). It seeks to answer questions such as: where were the Sino-European books printed? How did the printing places evolve over time? And which factors influenced this evolution? It does so by investigating the private publishing places of these books, which have been referred to as ‘tang printing’ (tangke 堂刻) or more specifically ‘church printing’ (jiaotang ke 教堂刻). By using historical and geospatial data visualization, this article locates, maps, and analyses the production centres of Sino-European books over the course of more than two centuries. It further puts the evolution of this industry in the context of the available printing techniques, the social actors, and the relevant socio-political changes. This investigation shows that the technology of woodblock printing and the flexibility and elasticity of the labour force made the expansion of publishing Sino-European texts relatively easy. As will be discussed below, the regional spread of printing centres over the course of time was determined by internal factors linked to social actors, such as the number of European missionaries and their productivity, and by socio-political external factors, such as periods of persecution and exile. After delineating the printed artefacts that are used for this research, this article establishes a historical and geospatial narrative of the development of this intercultural ‘book world’, visualizing its evolution through digital humanities methods. In doing so, it gives unique insight into the printing history of the early Sino-European encounter in China.
Distribution of Sino-European Intercultural Texts in Chinese Private Libraries of the Late Ming and the Early to Mid-Qing Periods (1582–c.1823)
Authors: Standaert Nicolas 
Published: October 2022

Abstract
This article focusses on the distribution of Sino-European books in the broad scholarly world: how did these books that are intercultural regarding authorship, content, and material aspect, reach their potential readers? And how widely were these books distributed? It investigates the extent to which these books were included in private libraries from the late Ming until the mid-Qing (1582–c.1823). Book printing had become very efficient in the second half of the sixteenth century and collecting books, both in printed and manuscript form, had become one of the favourite hobbies of (retired) scholars. Some of them accumulated very large libraries, and the catalogues of a few of these have been preserved.
Thirty-seven of the still extant catalogues of these libraries contain references to Sino-European books. These references provide the opportunity to investigate the distribution of such intercultural texts over a span of two hundred and fifty years. This article begins with a general presentation of these catalogues. Subsequently, individual catalogues are described in chronological order. When possible, a description is included of the collector’s link with European missionaries or Chinese Christians, as it is through these connections that the intercultural encounters around these texts took place. Next, by tracing the frequency of appearance of the works, this article explores what the extant catalogues can tell us about the distribution of Sino-European books. Finally, the focus moves to the ways the collectors classified these works in their catalogues. By investigating the bibliographic categories, this analysis reveals the intercultural negotiations that took place in the creation of the Sino-European book world.
Modeling Fuzzy Fidelity: Using Microsimulation to Explore Age, Period, and Cohort Effects in Secularization
Authors: Puga-Gonzalez Ivan , Voas David , Kiszkiel Lukasz , Bacon Rachel J. , Wildman Wesley J. , Talmont-Kaminski Konrad , Shults F. LeRon 
Published: October 2022

Abstract
This article presents a microsimulation that explores age, period, and cohort effects in the decline of religiosity in contemporary societies. The model implements a well-known and previously empirically validated theory of secularization that highlights the role of “fuzzy fidelity,” i.e., the percentage of a population whose religiosity is moderate (Voas 2009). Validation of the model involved comparing its simulation results to shifts in religiosity over 9 waves of the European Social Survey. Simulation experiments suggest that a cohort effect, based on weakened transmission of religiosity as a function of the social environment, appears to be the best explanation for secularization in the societies studied, both for the population as a whole and for the proportions of religious, fuzzy, and secular people.
Ikonografische in Deling van de Byzantijnse Kerkruimte
Authors: Jacobs A.A. A. 
Published: October 2022

Le principe de l’architecture byzantine peut être résumé en „COUPOLE SUR CUBE”.
Cette construction a un sens symbolique : elle exprime l’union du monde divin (coupole) au monde humain (cube) par l’incarnation. C’est ainsi qu’on appelle l’église byzantine l’architecture de L’INCARNATION.
La décoration de l’église correspond à cette idée maîtresse. L’ensemble des peintures veut nous représenter tous les grands évènements et personnages de la rédemption; chacun à sa place! En haut de la Coupole le „Pantocrator” et autour de Lui tous ceux qui ont joué un rôle dans la préparation et l’avènement du Regne céleste e.a. la Mère de Dieu, S. Jean Baptiste, les prophètes, Jes apôtres, les évangélistes.
En bas clans l’eglise elle-même on voit dans l’abside la Mère avec son fils divin et autour d’elle, sur les murs de l’eglise, les grands mysteres et Jes Saints du règne de Dieu. Le génie byzantin a réussi d’une manière magnifique à donner la synthése de la rédemption dans son architecture et peinture religieuses.
Two new nematode-trapping fungi (Arthrobotrys, Orbiliaceae) from Yunnan, China
Authors: ZHANG XIN , ZHANG FA , JIANG LIN , YANG YAO-QUAN , YANG XIAO-YAN , XIAO WEN 
Published: October 2022

Arthrobotrys jindingensis and A. tongdianensis, two new species isolated from the freshwater sediment and terrestrial soil in Lanping county, Yunnan, China, are introduced based on morphology and multi-locus phylogenetic analysis (ITS, TEF and RPB2). A. jindingensis is characterized by its branched conidiophores with irregularly swollen nodular apex, pyriform or obovoid, and 1-septate conidia. A. tongdianensis is characterized by its branched conidiophores, and ellipsoid or obovate, 1-septate conidia. Phylogenetic analysis supports them as two new species within Arthrobotrys with high support. The descriptions and illustrations of these two species are provided in this paper.
Organizing for Mars: A Task Management Perspective on Work within Spaceflight Multiteam Systems
Authors: Lungeanu Alina , Mesmer-Magnus Jessica R. , Niler Ashley A. , DeChurch Leslie A. , Contractor Noshir S. 
Published: October 2022

Objective The aim of this study was to examine how task, social, and situational factors shape work patterns, information networks, and performance in spaceflight multiteam systems (MTSs). Background Human factors research has explored the task and individual characteristics that affect decisions regarding when and in what order people complete tasks. We extend this work to understand how the social and situational factors that arise when working in MTSs affect individual work patterns. Methods We conducted a complex multi-site space analog simulation with NASA over the course of 3 years. The MTS task required participants from four teams (Geology, Robotics, Engineering, and Human Factors) to collaborate to design a well on Mars. We manipulated the one-way communication delay between the crew and mission support: no time lag, 60-second lag, and 180-second lag. Results The study revealed that team and situational factors exert strong effects: members whose teams have less similar mental models, those whose teams prioritize their team goal over the MTS goal, and those working in social isolation and/or under communication delay engage longer on tasks. Time-on-task positively predicts MTS information networks, which in turn positively predict MTS performance when communication occurs with a delay, but not when it occurs in real-time. Conclusion Our findings contribute to research on task management in the context of working in teams and multiteam systems. Team and situational factors, along with task factors, shape task management behavior. Application Social and situational factors are important predictors of task management in team contexts such as spaceflight MTSs.
Sinonasal Teratocarcinosarcoma Involving Orbital and Intracranial Extension: A Rare Case Report
Authors: Zhou Tao , Tian Yuan , Zhu Zhipeng , Yue Jianxin , Cheng Qing , Niu Xun , Zhou Yue , Fan Jun , Zhou Liuqing , Sun Haiying 
Published: October 2022

Sinonasal teratocarcinosarcoma (SNTCS) is one of the rarest and most highly invasive malignant neoplasms often found in the nasal cavity and paranasal sinuses. SNTCS is often misdiagnosed because of its morphological heterogeneity. Due to its rarity, clinical characteristics and optimal therapy have not been well-established. Here, we present a case of SNTCS with orbital and intracranial extensions. A 48-year-old male patient presented with left-side nasal obstruction for 3 years. He appeared with visual and neurological symptoms 2 months ago. On radiographic examination, a mass was observed in the left paranasal sinuses with orbital and intracranial extension involvement. The mass was surgically resected. In the future, knowledge of this entity may assist in the accurate diagnosis and proper management of SNTCS.
Virtual monoenergetic images by spectral detector computed tomography may improve image quality and diagnostic ability for ischemic lesions in acute ischemic stroke
Authors: Mellander Helena , Bengtsson Pär , Fransson Veronica , Ramgren Birgitta , Undrén Per , Drake Mattias , Ydström Kristina , Lätt Jimmy , Hilal Amir , Wassélius Johan , Ullberg Teresa 
Published: October 2022

Background Acute ischemic lesions are challenging to detect by conventional computed tomography (CT). Virtual monoenergetic images may improve detection rates by increased tissue contrast. Purpose To compare the ability to detect ischemic lesions of virtual monoenergetic with conventional images in patients with acute stroke. Material and Methods We included consecutive patients at our center that underwent brain CT in a spectral scanner for suspicion of acute stroke, onset <12 h, with or without (negative controls) a confirmed cortical ischemic lesion in the initial scan or a follow-up CT or magnetic resonance imaging. Attenuation was measured in predefined areas in ischemic gray (guided by follow-up exams), normal gray, and white matter in conventional images and retrieved in spectral diagrams for the same locations in monoenergetic series at 40–200 keV. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Visual assessment of diagnostic measures was performed by independent review by two neuroradiologists blinded to reconstruction details. Results In total, 29 patients were included (January 2018 to July 2019). SNR was higher in virtual monoenergetic compared to conventional images, significantly at 60–150 keV. CNR between ischemic gray and normal white matter was higher in monoenergetic images at 40–70 keV compared to conventional images. Virtual monoenergetic images received higher scores in overall image quality. The sensitivity for diagnosing acute ischemia was 93% and 97%, respectively, for the reviewers, compared to 55% of the original report based on conventional images. Conclusion Virtual monoenergetic reconstructions of spectral CIs may improve image quality and diagnostic ability in stroke assessment.
Effect of Lateral Extra-articular Tenodesis on the Rate of Revision Anterior Cruciate Ligament Reconstruction in Elite Athletes
Authors: Borque Kyle A. , Jones Mary , Laughlin Mitzi S. , Balendra Ganesh , Willinger Lukas , Pinheiro Vítor Hugo , Williams Andy 
Published: October 2022

Background: There is growing evidence that anterolateral procedures can reduce the risk of rerupture in high-risk recreational athletes undergoing primary anterior cruciate ligament (ACL) reconstruction (ACLR). However, this effectiveness has never been evaluated in elite athletes. Purpose: The purpose of this study was to evaluate the effectiveness of lateral extra-articular tenodesis (LET) in reducing revision rates in primary ACLR in elite athletes. Additionally, this study evaluated whether LET had a greater effect when combined with ACLR utilizing a hamstring or patellar tendon graft. Study Design: Cohort study; Level of evidence, 3. Methods: A consecutive cohort of elite athletes with an isolated ACL tear undergoing autograft patellar or hamstring tendon reconstruction with or without Lemaire LET were analyzed between 2005 and 2018. A minimum 2-year follow-up was required. The association between the use of LET and ACL graft failure as defined by revision ACLR was evaluated with univariate and multivariate logistic regression models. Results: A total of 455 elite athletes (83% men and overall age 22.5 ± 4.7 years) underwent primary ACLR with (n = 117) or without (n = 338) a LET procedure. Overall, 36 athletes (7.9%) experienced ACL graft failure, including 32 (9.5%) reconstructions without a LET and 4 (3.4%) with a LET. Utilization of LET during primary ACLR reduced the risk of graft failure by 2.8 times, with 16.5 athletes needing LET to prevent a single ACL graft failure. Multivariate models showed that LET significantly reduced the risk of graft rupture (relative risk = 0.325; P = .029) as compared with ACLR alone after controlling for sex and age at ACLR. Including graft type in the model did not significantly change the risk profile, and although a patellar tendon graft had a slightly lower risk of failure, this was not statistically significant ( P = .466). Conclusion: The addition of LET reduced the risk of undergoing revision by 2.8 times in elite athletes undergoing primary ACLR. This risk reduction did not differ significantly between the patellar tendon and hamstring tendon autografts. With these results, status as an elite athlete should be included in the indications for a LET, as they are at increased risk for ACL graft failure.
Progression of non-anemic macrocytosis to anemia in HIV-positive persons receiving zidovudine-containing regimens in a resource-limited setting
Authors: Nanthatanti Nithita , Charoenphak Sirima , Sungkanuparph Somnuek 
Published: October 2022

Background Non-anemic macrocytosis is frequently observed among HIV-positive persons treated with zidovudine in resource-limited settings. Although zidovudine-associated anemia is well recognized, the probability and predictors of progression from non-anemic macrocytosis to anemia are still unknown. Methods A retrospective cohort study was conducted among HIV-positive persons receiving zidovudine-containing antiretroviral therapy (ART) with non-anemic macrocytosis. Kaplan-Meier and Cox regression analyses were used to determine the probability and predictive factors of progression from non-anemic macrocytosis to anemia, respectively. Results Of 318 HIV-positive persons, 59.4% were male; mean age was 44.3 years. The median follow-up duration was 5.8 years. The probabilities of progression to anemia at 1, 3 and 4 years were estimated at 9.4, 17.3 and 21.3%, respectively. Almost all anemia was mild asymptomatic. Duration of zidovudine use [hazard ratio (HR) = 1.141; 95% confidence interval (CI),1.036-1.256; p = .007], CD4 count prior to start zidovudine [HR = 0.991; 95%CI,0.982-0.999; p = .038], and hematocrit level at development of macrocytosis [HR = 0.683; 95%CI,0.541-0.861; p = .001] were significant factors to predict progression to anemia. Conclusion Non-anemic macrocytosis in HIV-positive persons receiving zidovudine-containing ART can progress to anemia. Longer duration of zidovudine use, lower CD4 cell counts at ART initiation, and lower hematocrit level at development of macrocytosis are predictive factors for progression to anemia.