bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Patent Landscape of Polyhydroxyalkanoates Production by
Algae and Cyanobacteria
Authors: Procópio Dielle Pierotti , Cardoso Letícia Oliveira Bispo , Borrego Bruna Bacaro , Gracioso Louise Hase , Oller Nascimento Claudio Augusto , Perpetuo Elen Aquino , Stevani Cassius Vinicius , Freire Renato Sanches 
Published: December 2022

Background:
As global awareness regarding climate change and environmental
pollution outcomes arise, eco-friendly and negative emission technologies emerge.

Methods:
In this scenario, polyhydroxyalkanoate (PHA)-accumulating microorganisms
play an important role in the transition from the petrochemical-based non-biodegradable
polymer to renewable, eco-friendly, and biocompatible materials. More specifically, CO2
can be converted to biopolymers through photosynthesis by cyanobacteria and algae, posing
as a promising technology for renewable material, CO2, and petroleum-dependence
mitigations. However, although many microorganisms can accumulate PHA intracellularly,
limitations persist, such as the elevated cost and limited market availability.

Results:
Herein is presented a patent-based mapping on technological trends of PHAs production,
including its production by microalgae and cyanobacteria using the Questel Orbit
Intelligence software (version 1.9.8) in complement with the Espacenet Patent Search database.

Conclusion:
The inquiry on PHAs retrieved 34,243 patents filed since 1912, whereas 156
are related to their specific production by photosynthetic microorganisms, evidencing a
prospective market for intellectual property.
eHealth Literacy and Patient Portal Use and Attitudes: Cross-sectional Observational Study
Authors: Deshpande Nikita , Arora Vineet M , Vollbrecht Hanna , Meltzer David O , Press Valerie 
Published: December 2022

Background
Throughout the COVID-19 pandemic, patient portals have become more widely used tools of patient care delivery. However, not all individuals have equivalent access or ability to use patient portals.

Objective
The aim of this study is to evaluate the relationships between eHealth literacy (eHL) and patient portal awareness, use, and attitudes among hospitalized patients.

Methods
Inpatients completed patient portal surveys; eHL was assessed (eHealth Literacy Scale). Multivariable logistic regression analyses adjusted for age, self-reported race, gender, and educational attainment were completed with significance at P<.006 (Bonferroni correction).

Results
Among 274 participants, most identified as Black (n=166, 61%) and female (n=140, 51%), mean age was 56.5 (SD 16.7) years, and 178 (65%) reported some college or higher educational attainment. One-quarter (n=79, 28%) had low eHL (mean 27, SD 9.5), which was associated with lower odds of portal access awareness (odds ratio 0.11, 95% CI 0.05-0.23; P<.001), having ever used portals (odds ratio 0.19, 95% CI 0.10-0.36; P<.001), less perceived usefulness of portals (odds ratio 0.20, 95% CI 0.10-0.38; P=.001), and lower likelihood of planning to use portals in the coming years (odds ratio 0.12, 95% CI 0.06-0.25; P<.001). As time through the COVID-19 pandemic passed, there was a trend toward increased perceived usefulness of patient portals (53% vs 62%, P=.08), but average eHL did not increase through time (P=.81).

Conclusions
Low eHL was associated with less awareness, use, and perceived usefulness of portals. Perceived usefulness of portals likely increased through the COVID-19 pandemic, but patients’ eHL did not. Interventions tailored for patients with low eHL could ensure greater equity in health care delivery through the COVID-19 pandemic.
In Vivo and In Vitro Animal Models for Ulcer: A Conscious Review
Authors: Khan Mohd. Shahid , Arora Pankaj , Kalra Naresh , Arora Namita 
Published: December 2022

An ulcer is definite as a disease that happens owing to subside of the epithelial mucosal wall of the stomach when unguarded to an additional of hydrochloric acid and pepsin enzyme. Research for a potential anti-ulcer agent involves appropriate in vitro or in vivo models. Due to their anatomical, physiological, and genetic similarities to humans, rodents like mice and rats are ideal among the various animal models. In vivo methods are usually applied, as the sickly condition in human being can be imitated with distinct animal prototypes. The in vitro methods have been not often used for investigation of anti-ulcer agents.
Keywords: Ulcer, Hydrochloric Acid, Anti-ulcer agents, Pepsin Enzyme
A comparative pharmacodynamic and pharmacokinetic study of Vildagliptin SR 100 mg tablet in normal healthy adult male subjects
Authors: Warrier Sona , Joshi Harish R , Joshi Nidhi 
Published: December 2022

Background: Vildagliptin, a potent dipeptidyl peptidase IV inhibitor (DPP-4i), is usually administered twice daily to provide ≥90% inhibition of DPP-4 over 24 hours. Considering most type 2 diabetes (T2D) patients are on multiple medications, reducing dosing and pill burden can increase patient convenience. A 100 mg Vildagliptin sustained release (SR) formulation that would inhibit DPP-4 ≥ 80% over 24 hours with a lower dosing frequency was developed. The study was thus conducted to evaluate the pharmacodynamics, pharmacokinetics, and safety profile of once-daily Vildagliptin SR compared to twice-daily Vildagliptin immediate-release (IR) formulation.
Results: Twenty-four healthy adult male subjects were enrolled, and 22 completed the clinical phase of the study. The DPP-4 inhibition over time was comparable between the formulations. At 24 hrs single dose of once-daily Vildagliptin SR 100 mg tablet inhibited DPP4 by 89.58%, whereas twice-daily Vildagliptin IR 50 mg by 91.052%. The pharmacokinetic parameters like peak plasma concentration (Cmax), area under the plasma concentration-time curve from 0 hours to the last measurable concentration (AUC0-t) and AUC-time curve up to infinity (AUC0-inf) were not significantly different in both groups. Besides this, both groups reported no serious adverse effects during the study period.
Conclusion: The above result shows that once-daily Vildagliptin SR 100 mg is bioequivalent to twice-daily Vildagliptin IR 50 mg. Moreover, the ability of Vildagliptin SR 100 mg to provide above 80% DPP-4 inhibition coverage over 24 hrs may help to achieve a clinically meaningful glucose-lowering effect and reduce the pill burden in diabetes patients.
Keywords: Vildagliptin, dipeptidyl peptidase IV inhibitor (DPP-4i), type 2 diabetes (T2D) patients, pharmacokinetic parameters
Development of educational model of the pillow book kesgi as learning to brushing teeth for preschool children
Authors: Ngatemi Ngatemi , Purnama Tedi , Suwarsono Suwarsono 
Published: December 2022

Preschool children have higher health problems than elementary school age children. The high level of dental health problems in preschool children is due to the low behavior of maintaining oral hygiene, especially in brushing teeth, it is proven that the data on brushing teeth correctly at the age of > 3 years is only 2.3%. Efforts to improve dental health status in preschool children by establishing independence in brushing teeth as early as possible. The kesgi pillow book model is a development of the dental health pillow book media that researchers have made in previous studies, where there are various pillow book titles, so it is necessary to develop learning methods for the dental health pillow book media that have been created. This study aims to develop an educational model of the Kesgi pillow book as an effort to improve the dental and oral health status of preschool children. This research method uses Research and Development (R&D). The samples for the design stage of the Kesgi pillow book model with purposive sampling consisted of: dental health managers at the health office, curriculum managers at the education office, heads of community health centers, kindergarten principals, dental health workers and teachers. The research instrument used a question sheet and data collection techniques were carried out by interview. Data analysis for model validation with intraclass correlation coefficient. The results of expert validity show that the p-value = 0.000. Conclusion: educational model of the pillow book kesgi relevant as a learning model for preschool children in an effort to improve the dental health status of preschool children.
Keywords: Model, pillow book, learning, brushing teeth
Association of Sodium–Glucose Cotransporter 2 Inhibitors With Time to Dementia: A Population-Based Cohort Study
Authors: Wu Che-Yuan , Iskander Carina , Wang Christa , Xiong Lisa Y. , Shah Baiju R. , Edwards Jodi D. , Kapral Moira K. , Herrmann Nathan , Lanctôt Krista L. , Masellis Mario , Swartz Richard H. , Cogo-Moreira Hugo , MacIntosh Bradley J. , Rabin Jennifer S. , Black Sandra E. , Saskin Refik , Swardfager Walter 
Published: December 2022

OBJECTIVEType 2 diabetes (T2D) increases dementia risk, but clear evidence to recommend interventions that can mitigate that risk remains lacking. This population-based retrospective cohort study aimed to determine whether new use of sodium–glucose cotransporter 2 (SGLT2) inhibitors compared with dipeptidyl peptidase 4 (DPP-4) inhibitors was associated with lower dementia risk.RESEARCH DESIGN AND METHODSOntario residents aged ≥66 years who were new users of an SGLT2 inhibitor or a DPP-4 inhibitor from 1 July 2016 to 31 March 2021 entered the cohort. Incident dementia was identified using a validated algorithm for Alzheimer’s disease and related dementias. Propensity score–weighted Cox proportional hazards models were used to obtain adjusted hazard ratios (aHR) and CIs for time to incident dementia. To address reverse causality and disease latency, the observation window started at 1-year lag time from cohort entry. The primary analysis followed intention-to-treat exposure definition, and a secondary as-treated analysis was performed.RESULTSAmong 106,903 individuals, SGLT2 inhibitors compared with DPP-4 inhibitors were associated with lower risk of dementia (14.2/1,000 person-years; aHR 0.80 [95% CI 0.71–0.89]) over a mean follow-up of 2.80 years from cohort entry. When stratified by different SGLT2 inhibitors, dapagliflozin exhibited the lowest risk (aHR 0.67 [95% CI 0.53–0.84]), followed by empagliflozin (aHR 0.78 [95% CI 0.69–0.89]), whereas canagliflozin showed no association (aHR 0.96 [95% CI 0.80–1.16]). The as-treated analysis observed a larger association (aHR 0.66 [95% CI 0.57–0.76]) than the intention-to-treat analysis.CONCLUSIONSSGLT2 inhibitors showed an association with lower dementia risk in older people with T2D. Randomized controlled trials are warranted.
Influence of the Scalpel Finishing Technique on Marginal Gap Formation in Class II Resin Composite Restorations
Authors: Soliman S , Krastl G , Winkler A , Frankenberger R , Hahn B 
Published: December 2022

SUMMARY

Objectives
Modern adhesives and composites allow the restoration of deep defects. In such cases, the matrix technique is particularly challenging, and excess composite is a common problem. Removing such overhangs with a scalpel has already been described as a substance preserving or selective finishing technique. Clinically, restoration margins may appear as a white line after scalpel finishing, and it is unclear whether this line represents a marginal gap and/or whether scalpel finishing promotes marginal gap formation. Therefore, the aim of this study was to investigate the influence of scalpel finishing of deep Class II composite restorations on marginal gap formation.

Methods and Materials
Standardized mesioocclusal-distal (MOD) cavities were prepared and restored in 60 human molars randomly divided into six finishing protocol groups: G1, scalpels (SC); G2, oscillating files (OF); G3, finishing strips (FS); G4, scalpels and finishing strips (SC+FS); G5, scalpels and polishing discs (SC+PD); G6, polishing discs alone (PD, controls). The groups were additionally assigned to finishing and polishing in a phantom head (groups 1–4) or hand-held setting (groups 5–6) to simulate clinical and in-vitro research conditions, respectively. After restoration, artificial aging was performed by thermocycling (5–55°C, 2500 cycles) and mechanical loading (50 newtons (N) with 500,000 cycles) prior to scanning electron microscopy analysis of proximal restoration margin quality on the mesial and distal surfaces (n=120) of each tooth. Outcomes (perfect margin, marginal gap, overhang, marginal fracture) were statistically analyzed by t-test, Mann-Whitney U test, single-factor analysis of variance, post-hoc t-test, Kruskal-Wallis test and Dunn-Bonferroni correction for multiple group comparisons. Cohen’s effect size d(Cohen) was calculated to show the strength of the relationship between variables.

Results
Overall, marginal quality was significantly better in the hand-held setting (SC+PD and PD) than the phantom head setting (SC, OF, FS, SC+FS). The best marginal quality was achieved with oscillating files in the phantom head setting and with scalpels plus polishing discs in the hand-held setting. Marginal gaps occurred significantly more often with scalpels, but the proportion of gaps was very low and clinically insignificant. Finishing strips were the least effective instruments for removing overhangs but performed better in combination with scalpels.

Conclusions
Scalpel finishing can effectively and gently remove overhangs from enamel. However, blades should be used with caution as they can cut the dentin and cementum. Scalpel finishing does not lead to a clinically relevant increase in marginal gaps, but should be followed by polishing, whenever possible, to eliminate any marginal fractures that might be present.
Pelatihan Penulisan Bahan Ajar Berbasis Modul Bagi Guru Sejarah di Provinsi Lampung
Authors: Maskun Maskun , Imron Ali , Sumargono Sumargono , Perdana Yusuf 
Published: December 2022

Program pengabdian pelatihan penulisan bahan ajar berbasis modul bagi guru sejarah di Provinsi Lampung ini adalah bertujuan uuntuk meningkatkan kompetensi guru sejarah yang tergabung dalam Asosiasi di Provinsi Lampung dalam membuat modul yang relevan dengan karakteristik peserta didik, sehingga keterampilan guru meningkat dalam menyusun modul sejarah yang kreatif, inovatif dan menarik serta mengintegrasikan kearifan lokal. Metode yang digunakan dalam program pengabdian ini adalah sosialisasi dengan bentuk presentasi yang dilakukan oleh narasumber tim pengabdian sendiri dan pelatihan secara langsung dengan bentuk pendampingan kepada peserta pengabdian. Instrument yang digunakan adalah Materi yang tersaji dalam bentuk power point, Contoh modul dan buku ajar sejarah, dan Lembar evaluasi kegiatan dalam bentuk pre test dan post tes. Analisis data dilakukan secara kualitatif. Hasil pengabdian menunjukkan bahwa kegiatan pengabdian pengabdian pelatihan penulisan bahan ajar berbasis modul bagi guru sejarah di Provinsi Lampung terlaksana dengan baik dan meningkatnya kreativitas dan kompetensi guru terhadap modul sejarah.
Pelatihan Perawatan Berkala Pada Sepaeda Motor Bagi Pemuda Putus Sekolah dI Karang Taruna Kota Padang
Authors: Hidayat Nuzul , Setiawan M Yasep 
Published: December 2022

Karang Taruna (KT) adalah organisasi sosial wadah pengembangan generasimuda yang tumbuh dan berkembang atas dasar kesadaran dan tanggung jawab sosial dari, oleh, dan untuk masyarakat yang berorientasi pada peningkatan kesejahteraan sosial. Berdasarkan dengan surat Pengurus Karang Taruna Kota Padang Nomor: 010/KT.PDG. II/ 2021 tentang Permohonan Bantuan Program Pemberdayaan Pemuda di Kota Padang melalui LP2M UNP maka dalam hal ini Tim PKM UNP melihat peluang dapat membantu Karang Taruna sebagai mitra yaitu dalam pengembangan soft skill dan hard skill yang memiliki nilai ekonomi dan nilai peningkatan kemampuan personal dari pemuda-pemudi yaitu pelatihan service kendaraan bermotor. Kegiatan ini bisa menjadi salah satu solusi dari permasalahan yang dihadapi oleh Karang Taruna kota Padang. Jika para pemuda dilatih soft skill dan hard skill dalam service kendaraan bermotor maka para pemuda-pemudi akan mandiri dan dapat dilanjutkan ketaraf wirausaha. Dalam kegiatan ini yang akan difokuskan adalah pada service kendaran bermotor jenis sepeda motor, peserta adalah para pemuda-pemudi yang telah dipilih oleh Karang Taruna. Para peserta akan di beri pelatihan secara teori dan praktek dengan presentase 30% teori dan 70% praktek. Setelah kegiatan terlihat ada peningkatan kemampuan dari para peserta dari pemahaman tentang sepeda motor.
Upaya Pemutusan Rantai Penyebaran Virus Covid-19 Melalui Media Hand Sanitizer Sistem Injak di Tempat Ibadah
Authors: Fauza Naila 
Published: December 2022

Abstrak Tujuan artikel ini yaitu mahasiswa dapat memberikan sebuah inovasi kontribusi atas pengembangan serta penerapan keilmuanyang dapat diterapkan kepada masyarakat dalam upayapemutusan rantai penyebaran virus COVID-19 khususnya diKelurahan Sungai Pakning, Kecamatan Bukit Batu, KabupatenBengkalis. Metode pelaksanaan kegiatan yang digunakan di dalamartikel ilmiah ini adalah metode penelitian kualitatif dengan carawawancara. Sosialisasi protokol hidup sehat dan bersih denganmencuci tangan dan menjaga jarak adalah salah satu cara untukmenghindari virus COVID-19. Selain mencuci tangan, penggunaanhand sanitizer sebagai alternatif dalam membersihkan tangan juga marak dilakukan. Namun yang menjadi masalah daripenetapan penggunaan handsanitizer ditempat umum tersebutialah digunakan oleh banyak orang secara bergantianmenggunakan tangan, sehingga berpotensi memindahkan virusataupun bakteri pada tuas penekan dari botol handsanitizertersebut. Oleh sebab itu, dilakukan suatu inovasi baru terhadappemanfaatan alat hand sanitizer sistem injak sebagai media yangterjamin higienis dalam penggunaannya. Hasil kegiatanpengabdian masyarakat yang diperoleh adalah alat berupa HandSanitizer Sistem Injak (HSSI) yang diaplikasikan secara menyebardisetiap tempat ibadah se Kelurahan Sungai Pakning, KecamatanBukit Batu, Kabupaten Bengkalis. Alat ini memiliki sistem kerjasederhana untuk mengeluarkan cairan hand sanitizer tanpamenggunakan tangan dan cukup menekan dengan kaki,bertujuanagar dapat meminimalisir kemungkinan penyebaran virusCOVID-19.
Aplikasi Teknologi Tepat Guna pada Mesin Pencacah Pakan Ternak (Pelet) dalam Meningkatkan Efisiensi Kinerja Peternak Ikan
Authors: Jasman Jasman , Purwantono Purwantono 
Published: December 2022

Permasalahan pertama yang di alami peternak ikan adalah mahalnya pembelian bahan pembuatan pelet ikan. Sehingga hal ini mengakibatkan menurunnya pendapatan para peternak ikan. Bahan-bahan pembuatan pelet adalah Tepung Teri, Tepung Udang, Dedak Halus, Tepung Jagung daun pepaya, daun singkong dan lain-lain. Kegiatan pelaksanaan ini bertujuan untuk menyediakan mesin pencacah pakan ternak (pelet ikan) dalam meningkatkan efisiensi kinerja peternak ikan dalam pembuatan. Mesin pencacah pakan ternak (pelet ikan) memiliki salah satu mesin yang berguna untuk pencacah/perajang bahan pembuatan pelet, seperti daun singkong, daun pepaya dan lain-lain. Teknik yang digunakan adalah pengembangan teknologi tepat guna. Metode yang digunakan adalah pengembangan teknologi tepat guna. Kegiatan ini dilakukan dimulai merancang mesin pencacah bahan pembuatan pelet, pembuatan mesin, memberikan teori kepada peternak ikan tentang tentang bahan dan teknik pembuatan pelet, serta polatihan mengoperasian mesin pencacah bahan pembuatan pelet ikan. Hasil yang dicapai dalam program ini adalah tersedianya mesin pencacah pakan ternak (pelet ikan). serta dari program ini adalah peningkatan pemahaman dan informasi tentang mesin pencacah pakan ternak (pelet ikan). serta meningkatkan taraf kehidupan kelompok masyarakat Kanagarian Padang Belimbing, Kecamatan X Koto Singkarak, Kabupaten Solok, Sumatera Barat.
Aplikasi Digital E-Corp Berbasis Android Dengan Metode Waterfall Sebagai Solusi Cerdas Dalam Pengelolaan Manajemen dan Kewirausahaan Koperasi
Authors: Sofya Rani , Siwi Menik Kurnia , Thamrin Thamrin , Kurniawati Tri 
Published: December 2022

Koperasi Aneka Sulaman yang berada di Kabupaten Agam merupakan salah satu koperasi yang pernah berhasil menyandang status sebagai koperasi OVOP pada tahun 2017. Walaupun sudah menyandang prestasi sebagai koperasi OVOP berdasarkan survei kelapangan Koperasi Aneka Sulaman menghadapi beberapa kendala yaitu pertama terkait dengan pengelolaan manajeman koperasi yang kurang tertata. Kedua, permasalahan terkait dengan pemasaran dan penjualan produk yang menurun di masa pandemi covid 19. Berdasarkan paparan diatas maka sudah selayaknya Koperasi Aneka Sulaman ini mendapat bantuan dan perhatian lebih sehingga dapat bertahan pada era pandemi saat ini. Solusi yang bisa diberikan adalah dengan pembuatan aplikasi digital E-Corp berbasis android yang memuat semua fitur yang dibutuhkan baik oleh anggota dan pengurus maupun oleh konsumen kain sulaman.Pengabdian masyarakat ini dilaksanakan berupa kegiatan pelatihan. Pengurus dan anggota koperasi dilatih menggunakan aplikasi digital E-Corp serta menggunakan aplikasi penjualan online yang banyak dikenali masyarakat seperti shopee, tokopedia dan buka lapak. Luaran yang diharapkan dari solusi permasalahan pengelolaan manajemen adalah terciptanya satu aplikasi digital yang dikembangkan berbasis android dan diberi nama E-Corp (100%) yang dapat digunakan dan dioperasikan oleh anggota dan pengurus menggunakan handphone android. Luaran kegiatan pengabdian masyarakat ini diantaranya Aplikasi E-Corp, Artikel ilmiah pada jurnal pengabdian suluah bendang, Video yang diupload di youtube dan Berita di Tribunnews.com
Pelatihan Robot Line Follower untuk Guru dan Siswa SMK Negeri 1 Sungai Limau
Authors: Sardi Juli , Habibullah Habibullah 
Published: December 2022

Kegiatan ini dilatarbelakangi oleh kurangnya keterampilan guru dan siswa Jurusan Teknik Elektronika Industri SMK Negeri 1 Sungai Limau dalam bidang Robotika, khususnya pembuatan Robot Line Follower. Hal ini disebabkan oleh kurangnya sarana dan prasarana yang dimiliki sehingga berdampak rendahnya kualitas lulusan yang dihasilkan. Keahlian dalam bidang robotika merupakan salah satu keterampilan yang harus dimiliki oleh lulusan Jurusan Teknik Elektronika Industri. Tujuan dari kegiatan ini adalah meningkatkan keterampilan dan keahlian dalam membuat Robot Line Follower untuk guru dan siswa yang mengikuti pelatihan ini. kegiatan dilakukan selama tiga hari dengan jumlah peserta sebanyak 12 orang. Metode yang digunakan adalah ceramah, demonstrasi, praktek dan evaluasi. Ada 2 jenis evaluasi yang dilakukan yaitu pre test dan post test. Pre test dilaksanakan sebelum kegiatan pelatihan dimulai. Post test dilakukan setelah semua kegiatan pelatihan selesai dilaksanakan. Hasil dari pelatihan menunjukan nilai sig. (2-Tailed) pre test ke post test sebesar 0,018 dengan taraf signifikansi 0,001 (p<0,05). Hal ini menunjukan bahwa ada pengaruh yang signifikan pelatihan terhadap peningkatan keterampilan peserta dalam pembuatan Robot Line Follower.