bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEBIJAKAN PEMERINTAH DALAM PENGENDALIAN COVID-19 DI PROVINSI NUSA TENGGARA BARAT
Authors: Rahman Abdul , Utama Lalu Satria 
Published: January 2022

The COVID-19 pandemic has forced this nation to change attitudes and see things in different ways. All sectors in the country are not able to produce optimally, both the service sector and the field sector. However, the safety of the entire citizenry must be pursued even in difficult times. The role of academics in helping the government fight the COVID-19 pandemic is to share their thoughts in the fight against the pandemic. One of the things that can be done is to help the government disseminate Regulations Regional West Nusa Tenggara Province Number 7 Year 2020 About the Infectious Diseases Control and provide thoughts on anticipatory and preventive measures for COVID-19.
EVALUASI KEBIJAKSANAAN APLIKASI CITIZEN RELATION MANAGEMENT (CRM) DALAM MENYUKSESKAN JAKARTA SMART CITY
Authors: Handayani Ria 
Published: January 2022

Kemampuan birokrasi dalam pemerintahan dituntut untuk konsisten dan up to date dalam memberikan kinerjanya ditengah perkembangan masyarakat, lingkungan, dan kompetisi global. Salah satu bentuk konkret dari implementasi Kota Jakarta sebagai smart city adalah dengan menginisiasi sistem Citizen Relation Management (CRM). Namun dalam penerapannya ditemukan informasi bahwa persentase laporan CRM yang belum terselesaikan masih tinggi, selain dari pada itu penurunan kualitas penanganan pengaduan pada tahun 2019 dan tahun 2020. Penelitian ini bertujuan untuk menganalisis evaluasi kebijaksanaan aplikasi Citizen Relation Management (CRM) serta upaya yang dapat dilakukan demi menyukseskan Jakarta Smart City. Desain penelitian yang digunakan adalah kualitatif, dan pembahasannya dilakukan dengan memadukan antara analisis teoritis serta analisis ASOCA. Hasil penelitian ini menunjukan bahwa terdapat SDM yang tidak kompeten dan tidak adanya kontrol pihak ke tiga terhadap hasil penyelesaian pengaduan masyarakat. Sedangkan hasil analisis ASOCA ialah mengoptimalkan serta memfokuskan kemampuan SDM Pemerintah Provinsi Jakarta dalam memfasilitasi partisipasi masyarakat pada pelaksanaan aplikasi Citizen Relation Management (CRM).
Kata Kunci: Citizen Relation Management, Evaluasi, Kebijaksanaan
GOOD GOVERNANCE PADA PELAYANAN PUBLIK: SEBUAH USULAN MODEL PENGEMBANGAN BERBASIS PERILAKU
Authors: Saputra Nopriadi , Nugroho Riant 
Published: January 2022

ABSTRAK
Masyarakat dewasa ini membutuhkan pelayanan publik yang dapat membantu menyelesaikan permasalahan mereka. Penerapan praktek good governance pada pelayanan publik penting diterapkan dengan didukung model pengembangan yang relevan. Artikel ini mengusulkan model pengembangan pelayanan publik dengan pendekatan positive reinforcement theory. Sebuah pendekatan yang berbasis perilaku yang memetakan faktor-faktor apa saja yang berpengaruh baik pada level individu, kelompok, maupun organisasi terhadap perilaku transfaransi, akuntabilitas, responsible, integritas, dan fair dari petugas pelayanan. Perilaku tersebut yang didukung oleh budaya pelayanan, manajemen kinerja, ketangkasan belajar, serta kepemimpinan berbasis transformational, otentik, dan melayani.
Kata Kunci : pelayanan publik, tata kelola yang baik, positive reinforcement theory

ABSTRACT
Today's society needs public services that can help solve their problems. The application of good governance practices in public services is important to be implemented with the support of relevant development models. This article proposes a public service development model with a positive reinforcement theory approach. A behavior-based approach that maps out the factors that influence the level of individuals, groups, and organizations on the behavior of transparency, accountability, responsibility, integrity, and fairness of service personnel. These behaviors are supported by a service culture, performance management, learning agility, and transformational-authentic-servant leadership.
Keywords: public service, bureaucratic reform, positive reinforcement theory
Guanxin V Acts as an Antioxidant in Ventricular Remodeling
Authors: Liang Bo , Li Rui , Liang Yi , Gu Ning 
Published: January 2022

Background: Our previous studies have shown that Guanxin V (GXV) is safe and effective in the treatment of ventricular remodeling (VR), but its mechanism related to oxidative stress has not been studied deeply.Methods: We applied integrating virtual screening and network pharmacology strategy to obtain the GXV-, VR-, and oxidative stress-related targets at first, and then highlighted the shared targets. We built the networks and conducted enrichment analysis. Finally, the main results were validated by molecular docking and solid experiments.Results: We obtained 251, 11,425, and 9,727 GXV-, VR-, and oxidative stress-related targets, respectively. GXV-component-target-VR and protein–protein interaction networks showed the potential mechanism of GXV in the treatment of VR. The following enrichment analysis results gathered many biological processes and “two GXV pathways” of oxidative stress-related to VR. All our main results were validated by molecular docking and solid experiments.Conclusion: GXV could be prescribed for VR through the mechanism, including complex interactions between related components and targets, as predicted by virtual screening and network pharmacology and validated by molecular docking and solid experiments. Our study promotes the explanation of the biological mechanism of GXV for VR.
Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size
Authors: Huang Yihui , Guo Liang , Chen Jiwei , Wu Meng , Zhang Chao , Liu Zeming , Li Jinpeng , Li Kun , Xiong Zhongwei , Wu Qian , Li Zhengwei , Luo Kuan , Yuan Weiwei , Wu Xiaohui 
Published: January 2022

Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression and prognosis of patients with COVID-19.Methods: We retrospectively reviewed the information of 1,751 patients with COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate and multivariate Cox regression analyses as well as Logistics regression analyses, and Kaplan-Meier curves were used to determine the association between LDH levels and the prognosis of COVID-19 patients.Results: LDH was an independent risk factor for in-hospital death no matter it was taken as classified variable and continuous variable (all P = 0.001) but not for severe or critical illness status. The Kaplan-Meier curves for LDH level showed that an elevated level of LDH was associated with in-hospital death.Conclusions: In patients with COVID-19, the increased LDH level is associated with a higher risk of negative clinical prognosis and higher mortality. This will provide a reference for clinicians and researchers to understand, diagnose, and treat patients with COVID-19. Further prospective studies with larger sample sizes are needed to verify these findings.
Association Between Serum Follicle-Stimulating Hormone and Sarcopenia and Physical Disability Among Older Chinese Men: Evidence From a Cross-Sectional Study
Authors: Ke Yingying , Xu Jun , Zhang Xiaoyan , Guo Qihao , Zhu Yunxia 
Published: January 2022

Background: Sarcopenia is a geriatric syndrome characterized by progressive loss of muscle mass, function and quality and associated with a range of adverse health outcomes including disability. Despite a negative correlation between muscle mass and follicle-stimulating hormone (FSH) levels in postmenopausal women, it is unclear if FSH is associated with sarcopenia and its poor outcomes, especially in older men.Methods: We used cross-sectional data from 360 men aged over 80 who participated in health check-ups to investigate correlations between serum FSH and sarcopenia, individual sarcopenia components, low physical performance (gait speed ≤ 0.8 m/s) and instrumental activities of daily living (IADL) disability. Sarcopenia and severe sarcopenia were diagnosed according to the revised definition of the European Working Group on Sarcopenia in Old People (EWGSOP2).Results: The prevalence of sarcopenia was 17.8% in this population. In binary logistic regression analysis, compared with higher FSH group, lower FSH group showed a significant reduction in the risk of low calf circumference (a surrogate for muscle mass; OR 0.308, 95% CI 0.109–0.868, P = 0.026) after adjusting potential confounders including age, waist circumference, education, exercise, associated biochemical parameters, other sex hormones and high-sensitivity C-reactive protein. The correlation between FSH and low handgrip strength was marginally significant (OR 0.390, 95% CI 0.151–1.005, P = 0.051). No associations were observed between FSH and sarcopenia, severe sarcopenia, and disability in adjusted models.Conclusion: In older men, circulating FSH was not associated with sarcopenia, sarcopenia severity, the majority of its components and adverse health outcome (IADL disability), with the exception of low calf circumference. Further work is needed to better elucidate the association of FSH and low muscle quantity by adopting more accurate measurement method of appendicular skeletal muscle mass such as DXA, CT or MRI.
Choroidal Morphologic and Vascular Features in Patients With Myopic Choroidal Neovascularization and Different Levels of Myopia Based on Image Binarization of Optical Coherence Tomography
Authors: Wang Xinglin , Yang Jiarui , Liu Yushi , Yang Luling , Xia Huaqin , Ren Xiaotong , Hou Qingyi , Ge Yimeng , Wang Changguan , Li Xuemin 
Published: January 2022

Purpose: To characterize the choroidal morphologic and vascular features in different levels of myopes and patients with myopic choroidal neovascularization (mCNV).Methods: A total of 148 subjects were enrolled in this cross-sectional study, including 78 low-to-moderate myopes (LMM), 53 high myopes (HM), and 17 high myopic patients with mCNV. Ocular biometrics were measured using an optical low-coherence reflectometry device. Retinal and choroidal imaging was performed using enhanced depth imaging (EDI) spectral domain optical coherence tomography (OCT). Retinal parameters including retinal thickness and retinal volume were obtained from a built-in software. Binarization technique was adopted to investigate choroidal parameters including choroidal thickness (CT), vascular area, stromal area, and choroidal vascularity index (CVI). Choroidal parameters were measured at five locations to cover as much area of choroid as possible, and their patterns of distribution were further analyzed.Results: Patients with mCNV had an atrophic retina of comparable thickness to HM (273.65 ± 17.28 vs. 276.49 ± 13.29 μm, p = 0.47), but the choroid was thinner than that of HM (153.94 ± 15.12 vs. 236.09 ± 38.51 μm, p &lt; 0.001). Subfoveal CVI was greatest in the mCNV eyes (0.651 ± 0.009), followed by HM (0.645 ± 0.012) and LMM eyes (0.636 ± 0.012). Similar to CT, CVI was also found significantly different among these three groups at all five locations (p for trend &lt; 0.001 for all locations). Axial length (AL) was negatively correlated with retinal volume (r = −0.236, p = 0.009), which is the only significant finding in associations between ocular factors and retinal parameters. Strong, negative correlations were identified between AL and subfoveal choroidal thickness (SFCT, r = −0.820, p &lt; 0.001). However, AL was positively correlated with subfoveal CVI (r = 0.668, p &lt; 0.001). CVI was greater in myopic eyes with thinner choroid (r = −0.578, p &lt; 0.001). BCVA exhibited no significant association with CVI (r = 0.139, p = 0.092), but was negatively correlated with SFCT (r = −0.386, p &lt; 0.001) and positively correlated with AL (r = 0.351, p &lt; 0.001).Conclusion: Choroid in patients with mCNV was thinner yet more vascularized than that in HM and LMM subjects. CVI increased with a longer AL which was associated with a smaller SFCT, choroidal vascular area (VA), and total choroidal area (TCA). Better BCVA was achieved in subjects with thicker SFCT and shorter AL.
Plasma Cyclic Guanosine Monophosphate Is a Promising Biomarker of Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis
Authors: Sturm Lukas , Bettinger Dominik , Roth Lisa , Zoldan Katharina , Stolz Laura , Gahm Chiara , Huber Jan Patrick , Reincke Marlene , Kaeser Rafael , Boettler Tobias , Kreisel Wolfgang , Thimme Robert , Schultheiss Michael 
Published: January 2022

Introduction: Despite intensive research, reliable blood-derived parameters to detect clinically significant portal hypertension (CSPH) in patients with cirrhosis are lacking. As altered homeostasis of cyclic guanosine monophosphate (cGMP), the central mediator of vasodilatation, is an essential factor in the pathogenesis of portal hypertension, the aim of our study was to evaluate plasma cGMP as potential biomarker of cirrhotic portal hypertension.Methods: Plasma cGMP was analyzed in cirrhotic patients with CSPH (ascites, n = 39; esophageal varices, n = 31), cirrhotic patients without CSPH (n = 21), patients with chronic liver disease without cirrhosis (n = 11) and healthy controls (n = 8). cGMP was evaluated as predictor of CSPH using logistic regression models. Further, the effect of transjugular intrahepatic portosystemic shunt (TIPS) placement on plasma cGMP was investigated in a subgroup of cirrhotic patients (n = 13).Results: Plasma cGMP was significantly elevated in cirrhotic patients with CSPH compared to cirrhotic patients without CSPH [78.1 (67.6–89.2) pmol/ml vs. 39.1 (35.0–45.3) pmol/l, p &lt; 0.001]. Of note, this effect was consistent in the subgroup of patients with esophageal varices detected at screening endoscopy who had no prior manifestations of portal hypertension (p &lt; 0.001). Cirrhotic patients without CSPH displayed no significant elevation of plasma cGMP compared to patients without cirrhosis (p = 0.347) and healthy controls (p = 0.200). Regression analyses confirmed that cGMP was an independent predictor of CSPH (OR 1.042, 95% CI 1.008–1.078, p = 0.016). Interestingly, portal decompression by TIPS implantation did not lead to normalization of plasma cGMP levels (p = 0.101).Conclusions: Plasma cGMP is a promising biomarker of CSPH in patients with cirrhosis, especially with respect to screening for esophageal varices. The lacking normalization of plasma cGMP after portal decompression suggests that elevated plasma cGMP in cirrhotic portal hypertension is mainly a correlate of systemic and splanchnic vasodilatation, as these alterations have been shown to persist after TIPS implantation.
Objective Recognition of Tinnitus Location Using Electroencephalography Connectivity Features
Authors: Li Zhaobo , Wang Xinzui , Shen Weidong , Yang Shiming , Zhao David Y. , Hu Jimin , Wang Dawei , Liu Juan , Xin Haibing , Zhang Yalun , Li Pengfei , Zhang Bing , Cai Houyong , Liang Yueqing , Li Xihua 
Published: January 2022

Purpose: Tinnitus is a common but obscure auditory disease to be studied. This study will determine whether the connectivity features in electroencephalography (EEG) signals can be used as the biomarkers for an efficient and fast diagnosis method for chronic tinnitus.Methods: In this study, the resting-state EEG signals of tinnitus patients with different tinnitus locations were recorded. Four connectivity features [including the Phase-locking value (PLV), Phase lag index (PLI), Pearson correlation coefficient (PCC), and Transfer entropy (TE)] and two time-frequency domain features in the EEG signals were extracted, and four machine learning algorithms, included two support vector machine models (SVM), a multi-layer perception network (MLP) and a convolutional neural network (CNN), were used based on the selected features to classify different possible tinnitus sources.Results: Classification accuracy was highest when the SVM algorithm or the MLP algorithm was applied to the PCC feature sets, achieving final average classification accuracies of 99.42 or 99.1%, respectively. And based on the PLV feature, the classification result was also particularly good. And MLP ran the fastest, with an average computing time of only 4.2 s, which was more suitable than other methods when a real-time diagnosis was required.Conclusion: Connectivity features of the resting-state EEG signals could characterize the differentiation of tinnitus location. The connectivity features (PCC and PLV) were more suitable as the biomarkers for the objective diagnosing of tinnitus. And the results were helpful for clinicians in the initial diagnosis of tinnitus.
Reconstruction With 3D-Printed Prostheses After Sacroiliac Joint Tumor Resection: A Retrospective Case-Control Study
Authors: Pu Feifei , Liu Jianxiang , Shi Deyao , Huang Xin , Zhang Jingtao , Wang Baichuan , Wu Qiang , Zhang Zhicai , Shao Zengwu 
Published: January 2022

BackgroundSacroiliac joint tumor is rare, and the reconstruction after tumor resection is difficult. We aimed to analyze and compare the clinical effects of three-dimensional (3D) printed prostheses and bone cement combined with screws for bone defect reconstruction after sacroiliac joint tumor resection.MethodsTwelve patients with sacroiliac joint tumors who underwent tumor resection and received 3D-printed prostheses to reconstruct bone defects in our hospital from January 2014 to December 2020 were included in the study group Twelve matched patients who underwent sacroiliac joint tumor resection and reconstruction with bone cement and screws in the same time period were selected as the control group.ResultsIn the 3D-printing group, six cases were extensively excised, and six cases were marginally excised. All patients were followed up for 6–90 months, and the median follow-up time was 21 months. Among them, nine patients had disease-free survival, two survived with tumor recurrence, and one died due to tumor metastasis. The MSTS-93 score of the surviving patients was 24.1 ± 2.8. The operation time was 120.30 ± 14.50 min, and the intraoperative bleeding was 625.50 ± 30.00 ml. In the control group, seven cases were extensively excised, and five cases were marginally excised. All patients were followed up for 6–90 months, with a median follow-up time of 20 months. Among them, nine patients had disease-free survival, one survived with tumor recurrence, and two died due to tumor metastasis. The MSTS-93 score of the patients was 18.9 ± 2.6. The operation time was 165.25 ± 15.00 min, and the intraoperative bleeding was 635.45 ± 32.00 ml. There was no significant difference in survival status, intraoperative blood loss, or complications between the two groups (P&gt;0.05). However, there were statistically significant differences in operative time and postoperative MSTS-93 scores between the two groups (P&lt;0.05).ConclusionsAfter resection of the sacroiliac joint tumor, reconstruction using 3D printed prostheses was shorter and resulted in better movement function.
Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies
Authors: Wang Dandan , Liu Ruifeng , Zhang Qiuning , Luo Hongtao , Chen Junru , Dong Meng , Wang Yuhang , Ou Yuhong , Liu Zhiqiang , Sun Shilong , Yang Kehu , Tian Jinhui , Li Zheng , Wang Xiaohu 
Published: January 2022

PurposeGiven the higher precision accompanied by optimized sparing of normal tissue, charged particle therapy was thought of as a promising treatment for pancreatic cancer. However, systematic preclinical studies were scarce. We aimed to investigate the radiobiological effects of charged particle irradiation on pancreatic cancer cell lines.MethodsA systematic literature search was performed in EMBASE (OVID), Medline (OVID), and Web of Science databases. Included studies were in vitro English publications that reported the radiobiological effects of charged particle irradiation on pancreatic cancer cells.ResultsThirteen carbon ion irradiation and seven proton irradiation in vitro studies were included finally. Relative biological effectiveness (RBE) values of carbon ion irradiation and proton irradiation in different human pancreatic cancer cell lines ranged from 1.29 to 4.5, and 0.6 to 2.1, respectively. The mean of the surviving fraction of 2 Gy (SF2) of carbon ion, proton, and photon irradiation was 0.18 ± 0.11, 0.48 ± 0.11, and 0.57 ± 0.13, respectively. Carbon ion irradiation induced more G2/M arrest and a longer-lasting expression of γH2AX than photon irradiation. Combination therapies enhanced the therapeutic effects of pancreatic cell lines with a mean standard enhancement ratio (SER) of 1.66 ± 0.63 for carbon ion irradiation, 1.55 ± 0.27 for proton irradiation, and 1.52 ± 0.30 for photon irradiation. Carbon ion irradiation was more effective in suppressing the migration and invasion than photon irradiation, except for the PANC-1 cells.ConclusionsCurrent in vitro evidence demonstrates that, compared with photon irradiation, carbon ion irradiation offers superior radiobiological effects in the treatment of pancreatic cancer. Mechanistically, high-LET irradiation may induce complex DNA damage and ultimately promote genomic instability and cell death. Both carbon ion irradiation and proton irradiation confer similar sensitization effects in comparison with photon irradiation when combined with chemotherapy or targeted therapy.
Genomic Effects Associated With Response to Placebo Treatment in a Randomized Trial of Irritable Bowel Syndrome
Authors: Wang Rui-Sheng , Lembo Anthony J. , Kaptchuk Ted J. , Cheng Vivian , Nee Judy , Iturrino Johanna , Rao Meenakshi , Loscalzo Joseph , Silvester Jocelyn A. , Hall Kathryn T. 
Published: January 2022

Background and Aims: Irritable bowel syndrome (IBS), a functional pain disorder of gut-brain interactions, is characterized by a high placebo response in randomized clinical trials (RCTs). Catechol-O-methyltransferase (COMT) rs4680, which encodes high-activity (val) or low-activity (met) enzyme variants, was previously associated with placebo response to sham-acupuncture in an IBS RCT. Examining COMT effects and identifying novel genomic factors that influence response to placebo pills is critical to identifying underlying mechanisms and predicting and managing placebos in RCTs.Methods: Participants with IBS (N = 188) were randomized to three placebo-related interventions, namely, double-blind placebo (DBP), open-label placebo (OLP), or simply trial enrollment without placebo treatment [no placebo (i.e., no pill) treatment control (NPC)], for 6 weeks. COMT rs4680, gene-set, and genome-wide suggestive (p &lt; 10−5) loci effects on irritable bowel symptom severity score (IBS-SSS) across all participants were examined.Results: Participants with IBS homozygous for rs4680 met (met/met) had the greatest improvement across all arms, with significantly greater improvement compared to val/val in DBP (beta (SE), −89.4 (42.3); p = 0.04). Twelve genome-wide suggestive loci formed a gene regulatory network highly connected to EGR1, a transcription factor involved in placebo-related processes of learning, memory, and response to stress and reward. EGR1 gene expression in peripheral blood mononuclear cells (PBMC) was significantly reduced at the endpoint across all treatment arms (log fold-change, −0.15; p = 0.02). Gene-set enrichment analysis returned three genome-wide significant ontology terms (GO:0032968, GO:0070934, and GO:0070937) linked to transcription regulation and GO:0003918 associated with DNA topoisomerase regulation.Conclusion: These results suggest common molecular mechanisms in response to varying forms of placebo that may inform personalized IBS treatment and placebo response prediction.Clinical Trial Registration:ClinicalTrials.gov, Identifier: NCT0280224.