bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXTENSÃO UNIVERSITÁRIA NO FORMATO REMOTO COMO ESTRATÉGIA FORTALECEDORA DA INICIATIVA HOSPITAL AMIGO DA CRIANÇA:
Authors: Pinheiro de Medeiros Lays , Emanuelle da Silva Matias Thais , Dantas Diniz Damasceno Ana Luisa , Alanna Araújo de Aquino Débora , Marta Fernandes Pereira Dias Hosana , Pedrosa Lima Simone , Mahara Martins Azevedo Castro Gabrielle 
Published: December 2021

Objetivou-se relatar a experiência de discentes dos cursos de saúde da Universidade Federal do Rio Grande do Norte (UFRN) e profissionais do Hospital Universitário Ana Bezerra (HUAB) que atuam como colaboradores do projeto de extensão “Proteção, promoção e apoio a amamentação: fortalecendo a Iniciativa Hospital Amigo da Criança do HUAB”, assim como a eficácia do projeto no formato remoto como uma estratégia de promover saúde durante o período de pandemia de COVID-19. O projeto se deu por meio da produção e publicação de materiais nas mídias digitais disponíveis. Dessa forma, concluímos que houve uma boa aceitação por parte do público, interação satisfatória com as temáticas abordadas e a continuidade do fortalecimento da IHAC, que apoia o aleitamento materno em instituições hospitalares.

Palavras-chave: extensão; tecnologia digital; aleitamento materno.
Good Uptake of the COVID-19 Vaccine among Patients with Rheumatic
Diseases in the United Arab Emirates (UAE)
Authors: Elsheikh Azza A.M. , Badsha Humeira 
Published: December 2021

Background:
Many patients with rheumatic diseases are immunosuppressed and
take forms of immunomodulator medication. Hence, these patients might be at a heightened risk of Covid-19 and have special concerns in regard to vaccines, such as safety and efficacy. Vaccines have been available for the population of UAE as of January 2021, these being Pfizer (the United States and Europe), Sinopharm (China), and AstraZeneca (United Kingdom). The aim of our paper was to examine the rate of vaccine uptake among our patients with rheumatic conditions in the United Arab Emirates.

Methods:
A questionnaire was distributed among patients with rheumatic diseases attending a rheumatology specialised clinic in the United Arab Emirates. We collected data on 149 consecutive patients who were seen during a one-month period from 10/06/2021 to 10/07/2021 in Dubai.

Results:
The mean age of the patients was 45.9 +/- 41.3. The majority of the patients had underlying rheumatic diseases (86.9%), the rest having conditions such as soft tissue pain or to rule out rheumatic conditions. 48.5% were taking immunomodulators. 41.7% of respondents had other chronic diseases. It was also found that 18.9% had Covid-19 previously, all of whom recovered, with the average duration of the illness being 11 days.
99.1% of individuals reported that receiving the Covid-19 vaccine was extremely important, and 95.0% had already received the vaccination. Their reasoning for receiving the vaccination varied from medical advice (17.5%), general worry about infection/ reinfection of Covid-19 (65.3%), in order to travel (8.4%), employee requirement (5.6%), and other reasons (3.2%). Specifically, 48.3% chose the Pfizer vaccine, 39.8% had Sinopharm, and 11.9% had AstraZeneca. These decisions on which vaccine to choose were influenced by the availability of the vaccine (35.1%), medical advice (16.9%), effectiveness (15.5%), safety and side effect profile (18.2%), age restrictions (2.7%), experience/ advice from friends and family (8.1%) and other reasons (3.4%).

Conclusion:
Overall, an overwhelming majority of our patients (95.0%) with rheumatic
diseases in the specialised muscular-skeletal clinic in the UAE have received the Covid-19 vaccine. This reflects good public health service messaging and concentrated efforts from the medical community, UAE government, and the patient’s rheumatologists.
EBV Reactivation in A Case of DRESS Syndrome Associated with Lamotrigine: A Case Report
Authors: Kiblawi Mahmoud Ahmed , El Saleh Mohamad , El Ghul Ashraf 
Published: December 2021

Background:
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a rare, T-cell mediated hypersensitivity reaction that develops secondary to a drug reaction. Several drugs have been associated with DRESS syndrome, most commonly carbamazepine. The mechanism is not clearly understood. It is a life-threatening condition that can present with skin rash, hematologic abnormalities, lymphadenopathy, and organ failure.

Case Presentation:
The authors report a case of 43-year-old gentleman who developed DRESS syndrome secondary to lamotrigine and was found to have EBV reactivation. Patient was managed with supportive care; topical steroids and the culprit drug were discontinued. He had full recovery almost 2 weeks following treatment. DRESS syndrome can occur 2 weeks following exposure to an offending drug in susceptible individuals.

Conclusion:
Lamotrigine and EBV reactivation are not frequently reported in patients with DRESS syndrome. Therefore, physicians should be vigilant about this rare drug related hypersensitivity reaction in order to prevent life threatening complications.
A Practical Synthesis of Macrocyclic Schiff Base Bearing Hydroxyethyl
Pendants Utilizing Solubility Discrepancies
Authors: Li Runlai , Li Shu’an , Xia Tian , Ji Chunwei , Gu Na , Li Linzhe , Zhang Zhenming 
Published: December 2021

Abstract:
Six macrocyclic Schiff bases bearing hydroxyethyl pendants have been synthesized in high
yields via [2 + 2] condensation between the rigid dialdehydes and 2-[bis(2-aminoethyl)amino]ethanol
or 1-[bis(2-aminoethyl)amino]-2-propanol at 0oC for 12 hours in the CH3CN/H2O mixture. Solubility
discrepancies between macrocyclic products and raw materials in selected solvents enable a facile separation
and high yields, avoiding any intractable chromatographic purification. This straightforward
synthetic protocol provides a relatively facile resolution with potential widespread applications for the
synthesis of Schiff bases.
Environmental Factors as Diabetic Mediators: A Mechanistic Approach
Authors: Firdous Parveena , Nissar Kamran , Bashir Humayra , Hussain Qazi A. , Masoodi Shariq Rashid , Ganai Bashir Ahmad 
Published: December 2021

Abstract:
Despite substantial investment in research and treatment options, diabetes mellitus remains
a pressing public health concern with potential epidemic proportions globally. There are reports
that by the end of 2040, 642 million people will be suffering from diabetes. Also, according
to an estimation, 1.6 million deaths were caused directly by diabetes in 2016. Diabetes is a
metabolic disorder characterized by impaired glucose regulation in the body due to the destruction
of pancreatic β-cells or insulin resistance. Genetic propensity, unhealthy and imbalanced diet, obesity
and increasing urbanization are the common risk factors for diabetes. Besides this, it has been reported
that environmental pollutants like organic pesticides, heavy metals, and air pollutants act as
strong predisposing factors for diabetes owing to their highly bio-accumulative nature. These pollutants
disturb glucose homeostasis either by up-regulating or down-regulating the expression of diabetic
marker genes like insulin (INS) and glucokinase (GCK). Unfortunately, the molecular mechanism
of the role of pollutants in causing diabetes is not very clear. This mechanistic review provides
evidence of different environmental determinants, including persistent organic pollutants
(POPs), air pollutants, toxic metals, etc., in inducing diabetes and proposes a framework for the possible
mechanisms involved. It also illuminates the current status and future challenges, which will
not only broaden our understanding but can also be a reasonable platform for further investigation.
Pharmacokinetics Study of Rabdosia rubescens Drop Pills Based on
UPLC-MS/MS
Authors: Li Wei , Yu De-hong , Wei Xi-yu , Zhang Zhen-zhen , Xie Tao , Xie Yue-Sheng , Sun Yue , Yang Ting , Xu Wen-wu , Liu Hou-ru 
Published: December 2021

Background:
Rabdosia rubescens drop pills have the effects of clearing away heat and
toxin, detumescence, relieving pain.

Objective:
A simple and sensitive method for simultaneous determination of oridonin, ponicidin,
and rosmarinic acid in rat plasma was developed based on ultra performance liquid chromatography-
tandem mass spectrometry (UPLC-MS/MS).

Methods:
Chromatographic separation was performed on a Waters ACQUITY UPLC BEH C18
column (2.1 × 100 mm, 1.7 μm) with a mobile phase consisting of water containing 0.2% formic
acid (mobile phase A) and methanol (mobile phase B) at a flow rate of 0.3 mL/min over a total
run time of 3.8 min. All analytes were measured with optimized multiple reaction monitoring
(MRM) in positive and negative ion ESI mode.

Results:
The transitions of oridonin, ponicidin, rosmarinic acid, diphenhydramine, and chloramphenicol
were 365.3→347.3, 363.3→345.2, 359.0→160.9, 256.0→167.2, and 321.1→151.9, respectively.
The linear ranges were 1-256 ng/mL for ponicidin and rosmarinic acid and 2-512
ng/mL for oridonin. The validated method was stable and reliable. There was no significant difference
in the half-life (t1/2) of the three analytes at three doses. The area under the curve (AUC0-t)
and peak concentration (Cmax) of the three analytes decreased linearly in each dose range, and the
linear correlation R2 of each analyte under the three doses was greater than 0.95.

Conclusion:
This method was successfully applied to pharmacokinetic studies of oridonin, ponicidin,
and rosmarinic acid in rat plasma after intragastric administration of Rabdosia rubescens drop pills.
Application of Epoxy Resin for Improvement of the Banana Stem- Acoustic Panel
Authors: Riduan Mohd Azril , Jalil Mohd Jumain , Azmi Intan Suhada , Habulat Afifudin , Raofuddin Danial Nuruddin Azlan , Habri Hamzah Hafizuddin , Azmi Mohamad Heiry Mohd 
Published: December 2021

Background:Greener epoxidation by using vegetable oil to create an eco-friendly epoxide is being studied because it is a more cost-effective and environmentally friendly commodity that is safer than non-renewable materials. The aim of this research is to come up with low-cost solutions for banana trunk acoustic panels with kinetic modelling of epoxy-based palm oil.Method:In this study, the epoxidation of palm oleic acid was carried out by in situ performic acid to produce epoxidized palm oleic acid.Results:Banana trunk acoustic panel was successfully innovated based on the performance when the epoxy was applied. Lastly, a mathematical model was developed by using the numerical integration of the 4th order Runge-Kutta method, and the results showed that there is a good agreement between the simulation and experimental data, which validates the kinetic model.Conclusion:Overall, the peracid mechanism was effective in producing a high yield of epoxy from palm oleic acid that is useful for the improvement of acoustic panels based on the banana trunk.
Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic
Review and Meta-Analysis
Authors: Keya Tahmina Afrose , Leela Anthony , Fernandez Kevin , Habib Nasrin , Rashid Mumunur 
Published: December 2021

Background:
Respiratory tract infections are a primary cause of illness and mortality over the world.

Objective:
This study was aimed to investigate the effectiveness of vitamin C supplementation in preventing and treating respiratory tract infections.

Methods:
We used the Cochrane, PubMed, and MEDLINE Ovid databases to conduct our search. The inclusion criteria were placebo-controlled trials. Random effects meta-analyses were performed to measure the pooled effects of vitamin C supplementation on the incidence, severity, and duration of respiratory illness.

Results:
found ten studies that met our inclusion criteria out of a total of 2758.The pooled risk ratio (RR) of developing respiratory illness when taking vitamin C regularly across the study period was 0⸳94 (with a 95% confidence interval of 0⸳87 to 1⸳01) which found that supplementing with vitamin C lowers the occurrence of illness. This effect, however, was statistically insignificant (P= 0⸳09). This study showed that vitamin C supplementation had no consistent effect on the severity of respiratory illness (SMD 0⸳14, 95% CI -0⸳02 to 0⸳30: I2 = 22%, P=0⸳09). However, our study revealed that vitamin C group had a considerably shorter duration of respiratory infection (SMD -0⸳36, 95% CI -0⸳62 to -0⸳09, P = 0⸳01).

Conclusion:
Benefits of normal vitamin C supplementation for reducing the duration of respiratory tract illness were supported by our meta-analysis findings. Since few trials have examined the effects of therapeutic supplementation, further research is needed in this area.
Assessing Cognitive Function in Multiple Sclerosis With Digital Tools: Observational Study
Authors: Hsu Wan-Yu , Rowles William , Anguera Joaquin A , Anderson Annika , Younger Jessica W , Friedman Samuel , Gazzaley Adam , Bove Riley 
Published: December 2021

Background
Cognitive impairment (CI) is one of the most prevalent symptoms of multiple sclerosis (MS). However, it is difficult to include cognitive assessment as part of MS standard care since the comprehensive neuropsychological examinations are usually time-consuming and extensive.

Objective
To improve access to CI assessment, we evaluated the feasibility and potential assessment sensitivity of a tablet-based cognitive battery in patients with MS.

Methods
In total, 53 participants with MS (24 [45%] with CI and 29 [55%] without CI) and 24 non-MS participants were assessed with a tablet-based cognitive battery (Adaptive Cognitive Evaluation [ACE]) and standard cognitive measures, including the Symbol Digit Modalities Test (SDMT) and the Paced Auditory Serial Addition Test (PASAT). Associations between performance in ACE and the SDMT/PASAT were explored, with group comparisons to evaluate whether ACE modules can capture group-level differences.

Results
Correlations between performance in ACE and the SDMT (R=–0.57, P<.001), as well as PASAT (R=–0.39, P=.01), were observed. Compared to non-MS and non-CI MS groups, the CI MS group showed a slower reaction time (CI MS vs non-MS: P<.001; CI MS vs non-CI MS: P=.004) and a higher attention cost (CI MS vs non-MS: P=.02; CI MS vs non-CI MS: P<.001).

Conclusions
These results provide preliminary evidence that ACE, a tablet-based cognitive assessment battery, provides modules that could potentially serve as a digital cognitive assessment for people with MS.

Trial Registration
ClinicalTrials.gov NCT03569618; https://clinicaltrials.gov/ct2/show/NCT03569618
Paving the Way for Electronic Patient-Centered Measurement in Team-Based Primary Care: Integrated Knowledge Translation Approach
Authors: Davis Selena , Antonio Marcy , Smith Mindy , Burgener Paul , Lavallee Danielle C , Price Morgan , Fletcher Sarah C , Lau Francis 
Published: December 2021

Background
Patient-centered measurement (PCM) aims to improve the overall quality of care through the collection and sharing of patient values, outcomes, and perspectives. However, the use of PCM in care team decisions remains limited. Integrated knowledge translation (IKT) offers a collaborative, adaptive approach to explore best practices for incorporating PCM into primary care practices by involving knowledge users, including patients and providers, in the exploratory process.

Objective
This study aims to test the feasibility of using patient-generated data in team-based care; describe the use of these data for team-based mental health care; and summarize patient and provider care experiences with PCM.

Methods
We conducted a multi-method exploratory study in a rural team-based primary care clinic using IKT to co-design, implement, and evaluate the use of PCM in team-based mental health care. Care pathways, workflows, and quality improvement activities were adjusted iteratively to improve integration efforts. Patient and provider experiences were evaluated using individual interviews relating to the use of PCM and patient portals in practice. All meeting notes, interview summaries, and emails were analyzed to create a narrative evaluation.

Results
During co-design, a care workflow was developed to incorporate electronically collected patient-generated data from the patient portal into the electronic medical record, and customized educational tools and resources were added. During implementation, care pathways and patient workflows for PCM were developed. Patients found portal use easy, educational, and validating, but data entries were not used during care visits. Providers saw the portal as extra work, and the lack of portal and electronic medical record integration was a major barrier. The IKT approach was invaluable for addressing workflow changes and understanding the ongoing barriers to PCM use and quality improvement.

Conclusions
Although the culture toward using PCM is changing, the use of PCM during care has not been successful. Patients felt validated and supported through portal use and could be empowered to bring these data to their visits. Training, modeling, and adaptable PCM methods are required before PCM can be integrated into routine care.
Virtual Reality in Medical Students’ Education: Scoping Review
Authors: Jiang Haowen , Vimalesvaran Sunitha , Wang Jeremy King , Lim Kee Boon , Mogali Sreenivasulu Reddy , Car Lorainne Tudor 
Published: December 2021

BackgroundVirtual reality (VR) produces a virtual manifestation of the real world and has been shown to be useful as a digital education modality. As VR encompasses different modalities, tools, and applications, there is a need to explore how VR has been used in medical education.ObjectiveThe objective of this scoping review is to map existing research on the use of VR in undergraduate medical education and to identify areas of future research.MethodsWe performed a search of 4 bibliographic databases in December 2020. Data were extracted using a standardized data extraction form. The study was conducted according to the Joanna Briggs Institute methodology for scoping reviews and reported in line with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines.ResultsOf the 114 included studies, 69 (60.5%) reported the use of commercially available surgical VR simulators. Other VR modalities included 3D models (15/114, 13.2%) and virtual worlds (20/114, 17.5%), which were mainly used for anatomy education. Most of the VR modalities included were semi-immersive (68/114, 59.6%) and were of high interactivity (79/114, 69.3%). There is limited evidence on the use of more novel VR modalities, such as mobile VR and virtual dissection tables (8/114, 7%), as well as the use of VR for nonsurgical and nonpsychomotor skills training (20/114, 17.5%) or in a group setting (16/114, 14%). Only 2.6% (3/114) of the studies reported the use of conceptual frameworks or theories in the design of VR.ConclusionsDespite the extensive research available on VR in medical education, there continue to be important gaps in the evidence. Future studies should explore the use of VR for the development of nonpsychomotor skills and in areas other than surgery and anatomy.International Registered Report Identifier (IRRID)RR2-10.1136/bmjopen-2020-046986
THE HISTORY OF THE LIMIT STATE DESIGN METHOD
Authors: Perelmuter Anatoly 
Published: December 2021

This paper analyzes the 70-year history of development of the limit state design method (LSDM) focusing on the fundamentals of the design codes based on this method and considers proposals for improving the LSDM and its justification. It was also noted that the reaction of the system in any of its fixed states is not always sufficient to assess the reliability of the system, and therefore it is necessary to analyze the rate of loss of resistance of load-bearing structures. However, probabilistic considerations were not enough due to the lack of reliable statistical data in the area of extreme sections of the distribution curves and a number of other circumstances (features of control procedures, different behavior of the material in the structure and in the samples, etc.). This paper analyzes some fundamental issues that should be solved when developing the method for the nonlinear analysis.
LA SITUACIÓN DE LOS DERECHOS HUMANOS DEL PUEBLO RAPA NUI: EL DERECHO DE LIBRE DETERMINACIÓN Y LOS DERECHOS TERRITORIALES
Authors: Bárrios Luísa Brandão 
Published: December 2021

Una de las más graves vulneraciones a los derechos de los Rapa Nui, que se mantiene hasta la fecha, es la usurpación de su territorio, mediante la inscripción de la totalidad de la Isla de Pascua a nombre del Estado de Chile (1933), época en que los Rapa Nui eran considerados apátridas y carecían de todo derecho civil y político. Dicha inscripción se realizó en el Conservador de Bienes Raíces de Valparaíso, ciudad continental ubicada a más de 4.000 kilómetros de la isla, excluyendo cualquier posibilidad de oposición, utilizándose como argumento que la tierra carecería de dueño. A partir de la “Ley Pascua”, se reconocen derechos de ciudadanía y otros beneficios a los Rapa Nui, lo que se refuerza con legislaciones posteriores como la “Ley Indígena” (Ley 19.253 DO 05.10.93), a principios de la década del 90 que otorga especiales derechos a los Rapa Nui y la ratificación del Convenio 169 de la OIT sobre Pueblos Indígenas y Tribales en Países Independientes. En la práctica, dicha legislación no se ha traducido en la devolución de la tierra y respeto a derechos territoriales y de libre determinación de los Rapa Nui. La situación de los derechos humanos del Pueblo Rapa Nui y de sus demandas, con especial mención a los derechos territoriales y de libre determinación, es de suma importancia, bien como, la demanda de participación política efectiva y control sobre sus instituciones políticas por la vía del establecimiento de un “estatuto especial”, de una modalidad de control migratorio y una especial referencia a los esfuerzos por lograr el cumplimiento del derecho a la consulta previa a los pueblos indígenas; los antecedentes con respecto a su demanda colectiva por recuperar su territorio ancestral, por el respeto a su derecho a la autodeterminación de acuerdo al derecho Internacional y por el pleno reconocimiento del Acuerdo de Voluntades de 1888. La situación de los derechos de los pueblos indígenas en Chile en general se destaca por la falta de reconocimiento Constitucional, la inexistencia de un mecanismo oficial para la consulta previa en caso de medidas susceptibles de afectarles directamente o asegurar su participación política y la carencia de medidas claras para la implementación del Convenio 169 de la OIT vigente en Chile desde septiembre de 2009. Hasta la fecha no existe este reconocimiento constitucional, que surgirá con la reforma constitucional, a la que asistimos actualmente.