bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the culprit artery via 12‐lead electrocardiogram in inferior wall ST‐segment elevation myocardial infarction: A meta‐analysis
Authors: Zhou Peng , Wu Yingying , Wang Meng , Zhao Yikai , Yu Yangjie , Waresi Maieryemu , Li Huiyang , Jin Bo , Luo Xinping , Li Jian 
Published: November 2022

AbstractBackgroundInferior wall ST‐segment elevation myocardial infarction (STEMI) is mostly caused by acute occlusion of right coronary artery (RCA) and left circumflex artery (LCX). Several methods and algorithms using 12‐lead ECG were developed to localize the lesion in inferior wall STEMI. However, the diagnostic properties of these methods remain under‐recognized.AimsThe aim of this meta‐analysis is to compare the diagnostic properties among the methods of identifying culprit artery in inferior wall STEMI using 12‐lead ECG.MethodsWe performed a meta‐analysis to calculate the pooled sensitive, specificity, area under the curve (AUC) and diagnostic odds ratio (DOR) of each method.ResultsThirty‐three studies with 4414 participants were included in the analysis. Methods using double leads had better diagnostic properties, especially ST‐segment elevation (STE) in III > II [with pooled sensitivity 0.89 (0.84–0.93), specificity 0.68 (0.57–0.79), DOR 17 (9–32), AUC 0.88 (0.85–0.91)], ST‐segment depression (STD) in aVL > I [with pooled sensitivity 0.82 (0.72–0.90), specificity 0.69 (0.48–0.86), DOR 11 (4–29), AUC 0.85 (0.81–0.88)], and STD V3/STE III ≤1.2 [with pooled sensitivity 0.88 (0.78–0.95), specificity 0.59 (0.42–0.75), DOR 12 (5–27), AUC 0.82 (0.78–0.85)]. Diagnostic algorithms, including Jim score[pooled sensitivity 0.70 (0.55–0.85), specificity 0.88 (0.75–0.96)], Fiol's algorithm [pooled sensitivity 0.54 (0.44–0.62), specificity 0.92 (0.88–0.96)] and Tierala's algorithm [pooled sensitivity 0.60 (0.49–0.71), specificity 0.91 (0.86–0.96)], were not superior to these simple methods.ConclusionsOur meta‐analysis indicated that diagnostic methods using double leads had better properties. STE in III > II together with STD in aVL > I may be the most ideal method, for its accuracy and convenience.
Drivers of support for citizen science across state wildlife management agencies in the United States
Authors: Van Buskirk Amanda N. , Boley Bertram Bynum , Killmaster Charlie H. , Johannsen Kristina L. , D'Angelo Gino J. 
Published: November 2022

AbstractCitizen science (CS) is gaining recognition as a valuable approach to meet data needs for environmental projects while fostering collaboration between scientists and members of the public. Despite increasing implementation of CS by natural resource entities, organizations’ motivations for engaging in CS remain poorly understood. We examined the utility of the theory of planned behavior (TPB) and social exchange theory (SET) in identifying factors influencing support of CS by scientific organizations. To test predictions of the TPB and SET theories, we surveyed (quantitative, web based) state wildlife agency staff in the United States on their perceptions of organizational engagement in CS. We divided questions that measured TPB items into individual and organizational components to address the influence of personal‐ and organization‐level decision‐making on staff perceptions and attitudes. We used structural equation modeling to identify key constructs that influence staff support of CS in state wildlife agencies. The survey yielded 627 responses across 44 states. Both TPB and SET constructs accurately predicted staff support of CS; however, measures from SET (e.g., public engagement benefits and costs of CS to scientific credibility) were most influential (i.e., TPB constructs had less impact). Our findings indicate that organizational support for CS is primarily influenced by assessment of trade‐offs among perceived costs and benefits. Indicators of support for CS were further elucidated by including measures from the TPB model. Based on our results, we suggest that natural resource entities give careful consideration to CS project design, develop thorough communication and data management plans, and practice iterative evaluation of CS project productivity.
Application of decision tools to ethical analysis in biodiversity conservation
Authors: Biasetti Pierfrancesco , Hildebrandt Thomas B. , Göritz Frank , Hermes Robert , Holtze Susanne , Stejskal Jan , Galli Cesare , Pollastri Ilaria , Muzzo Alessia , Lekolool Isaac , Ndereeh David , Omondi Patrick , Kariuki Linus , Mijele Domnic , Mutisya Samuel , Ngulu Stephen , de Mori Barbara 
Published: November 2022

AbstractAchieving ethically responsible decisions is crucial for the success of biodiversity conservation projects. We adapted the ethical matrix, decision tree, and Bateson's cube to assist in the ethical analysis of complex conservation scenarios by structuring these tools so that they can implement the different value dimensions (environmental, social, and animal welfare) involved in conservation ethics. We then applied them to a case study relative to the decision‐making process regarding whether or not to continue collecting biomaterial on the oldest of the two remaining northern white rhinoceroses (Ceratotherium simum cottoni), a functionally extinct subspecies of the white rhinoceros. We used the ethical matrix to gather ethical pros and cons and as a starting point for a participatory approach to ethical decision‐making. We used decision trees to compare the different options at stake on the basis of a set of ethical desiderata. We used Bateson's cube to establish a threshold of ethical acceptability and model the results of a simple survey. The application of these tools proved to be pivotal in structuring the decision‐making process and in helping reach a shared, reasoned, and transparent decision on the best option from an ethical point of view among those available.
Ranking species based on sensitivity to perturbations under non‐equilibrium community dynamics
Authors: Medeiros Lucas P. , Allesina Stefano , Dakos Vasilis , Sugihara George , Saavedra Serguei 
Published: November 2022

AbstractManaging ecological communities requires fast detection of species that are sensitive to perturbations. Yet, the focus on recovery to equilibrium has prevented us from assessing species responses to perturbations when abundances fluctuate over time. Here, we introduce two data‐driven approaches (expected sensitivity and eigenvector rankings) based on the time‐varying Jacobian matrix to rank species over time according to their sensitivity to perturbations on abundances. Using several population dynamics models, we demonstrate that we can infer these rankings from time‐series data to predict the order of species sensitivities. We find that the most sensitive species are not always the ones with the most rapidly changing or lowest abundance, which are typical criteria used to monitor populations. Finally, using two empirical time series, we show that sensitive species tend to be harder to forecast. Our results suggest that incorporating information on species interactions can improve how we manage communities out of equilibrium.
Seizure outcome of pediatric magnetic resonance‐guided laser interstitial thermal therapy versus open surgery: A matched noninferiority cohort study
Authors: Yossofzai Omar , Stone Scellig , Madsen Joseph , Moineddin Rahim , Wang Shelly , Ragheb John , Mohamed Ismail , Bollo Robert , Clarke Dave , Perry M. Scott , Weil Alexander G. , Raskin Jeffrey , Pindrik Jonathan , Ahmed Raheel , Lam Sandi , Fallah Aria , Maniquis Cassia , Andrade Andrea , Ibrahim George M. , Drake James , Rutka James , Tailor Jignesh , Mitsakakis Nicholas , Puka Klajdi , Widjaja Elysa 
Published: November 2022

AbstractObjectiveMinimally invasive magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) has been proposed as an alternative to open epilepsy surgery, to address concerns regarding the risk of open surgery. Our primary hypothesis was that seizure freedom at 1 year after MRgLITT is noninferior to open surgery in children with drug‐resistant epilepsy (DRE). The secondary hypothesis was that MRgLITT has fewer complications and shorter hospitalization than surgery. The primary objective was to compare seizure outcome of MRgLITT to open surgery in children with DRE. The secondary objective was to compare complications and length of hospitalization of the two treatments.MethodsThis retrospective multicenter cohort study included children with DRE treated with MRgLITT or open surgery with 1‐year follow‐up. Exclusion criteria were corpus callosotomy, neurostimulation, multilobar or hemispheric surgery, and lesion with maximal dimension > 60 mm. MRgLITT patients were propensity matched to open surgery patients. The primary outcome was seizure freedom at 1 year posttreatment. The difference in seizure freedom was compared using noninferiority test, with noninferiority margin of −10%. The secondary outcomes were complications and length of hospitalization.ResultsOne hundred eighty‐five MRgLITT patients were matched to 185 open surgery patients. Seizure freedom at 1 year follow‐up was observed in 89 of 185 (48.1%) MRgLITT and 114 of 185 (61.6%) open surgery patients (difference = −13.5%, one‐sided 97.5% confidence interval = −23.8% to ∞, pNoninferiority = .79). The lower confidence interval boundary of −23.8% was below the prespecified noninferiority margin of −10%. Overall complications were lower in MRgLITT compared to open surgery (10.8% vs. 29.2%, respectively, p < .001). Hospitalization was shorter for MRgLITT than open surgery (3.1 ± 2.9 vs. 7.2 ± 6.1 days, p < .001).SignificanceSeizure outcome of MRgLITT at 1 year posttreatment was inferior to open surgery. However, MRgLITT has the advantage of better safety profile and shorter hospitalization. The findings will help counsel children and parents on the benefits and risks of MRgLITT and contribute to informed decision‐making on treatment options.
Somatic symptoms and related disorders in a large cohort of people with epilepsy: A cohort study
Authors: Shen Sisi , Dong Zaiquan , Sander Josemir W. , Zhou Dong , Li Jinmei 
Published: November 2022

AbstractObjectiveThis study was undertaken to characterize somatic symptoms and related disorders (SSD) in epilepsy.MethodsAdults with epilepsy under active follow‐up at a tertiary epilepsy center were consecutively enrolled. The diagnosis of SSD was performed by an experienced psychologist based on the structured clinical interview for Statistical Manual of Mental Disorders, 5th edition. Detailed social/demographic data, epilepsy features, psychiatric features, life quality, disability, and economic burden were collected and compared between people with SSD and those without. Bodily distress syndrome checklist, Somatic Symptom Disorder–B Criteria Scale, Patient Health Questionnaire‐9, and Generalized Anxiety Disorder seven‐item scale (GAD‐7) were used to evaluate SSD individuals' somatic symptoms, symptom‐related psychological distress, and depressive and anxious symptoms. Quality of life and disability were assessed by Quality of Life in Epilepsy Inventory 31 (QOLIE‐31) and World Health Organization Disability Assessment Schedule V.2.0 (WHO DAS 2.0). A risk prediction nomogram was generated using least absolute shrinkage and selection operator (LASSO) analysis and validated.ResultsOne hundred fifty of 631 participants (24%) were diagnosed with SSD. In people with SSD, the top three most common somatic symptoms were memory impairment, headache, and dizziness (85%, 80%, and 78%, respectively), and multiple systems were involved in most (82%) people with SSD. Compared with people without SSD, those with SSD had lower QOLIE‐31 total scores, and higher WHO DAS 2.0 scores and disease economic burdens. LASSO analysis suggested that a history of severe traumatic brain injury, hippocampal sclerosis, low seizure worry and medication effects scores on QOLIE‐31, multiple systems affected by somatic symptoms, and a high GAD‐7 score were risk factors of SSD. The nomogram was validated for good accuracy in the training and testing cohorts.SignificanceSSD are likely to be a common comorbidity in epilepsy and harm epilepsy prognosis. Our risk prediction nomogram was successfully developed but needs further validation in larger cohorts.
Medical decision‐making for adolescents with depression: A bibliometric study and visualization analysis via CiteSpace
Authors: Hua Nan , Tan Xiangmin , He Yuqing , Sun Mei , Wang Xiuhua 
Published: November 2022

AbstractThis study focussed on evaluating the status of recent research on medical decision‐making for adolescents with depression and identifying research hotspots and frontiers via CiteSpace. We extracted studies that were concerned with medical decision‐making for adolescents with depression from the Web of Science Core Collection (WoSCC), covering the period from 1 January 1999 to 20 September 2022. We used CiteSpace to generate online maps of worldwide cooperation among countries, institutions, and authors. Hotspots and frontiers were systematically summarized. A total of 368 papers related to medical decision‐making for adolescents with depression were obtained from WoSCC. The most prolific author was Nick Midgley (seven papers). The United States and University College London were the leading country and institution in this research area, with 177 and 17 papers, respectively. Countries, institutions, and authors all actively collaborated. Main recent research trends include the preference or attitude towards medical treatment in adolescents with depression; approaches for adolescents with depression to seeking medical help; and the key role of parent, family, and primary care in medical decision‐making for adolescents. Thus, further attention should be paid to determining how to promote the role of parents, families, and primary care in the decision‐making process and create appropriate online help‐seeking tools and decision aids to facilitate shared decision‐making in the future.
A highly sensitive turn‐off fluorescent probe based on 2D Eu(III)‐MOFs nanosheets for glutathione in vitro and living cells
Authors: Zhu Mengmeng , Liu Yunpeng , Xia Chao , Zeng Hairong , Hu Song , Jiang Danyu , Zhou Guohong , Li Huili 
Published: November 2022

AbstractGlutathione (GSH) is generally used as an effective and sensitive tumor marker because its abnormal levels are associated with high free radical level in tumor. In this work, GSH could be easily detected by a kind of designed Eu‐based metal–organic frameworks (Eu‐MOFs, named Eu(DTBA)) fluorescent sensor. Due to the “antenna effect” of 4,4′‐dithiobenzoic acid (4,4′‐DTBA) ligands on Eu3+, Eu(DTBA) emits the strong characteristic red light of Eu3+ under ultraviolet excitation. Moreover, the emission intensity strongly depends on GSH concentrations. Thus, Eu(DTBA) can serve as a turn‐off fluorescent switch of GSH because its framework structure can easily be destroyed by GSH that leads to the fluorescence quenching. Remarkably, during sensing GSH, Eu(DTBA) has shown many appealing performances, such as broad a response window (0–20 mM), fast response (3 min), high sensitivity (LOD = 0.35 µM), and excellent anti‐interference ability. The real bioimaging application has demonstrated that the reported Eu(DTBA) can be used as an excellent bioimaging agent to successfully distinguish tumor cells from normal cells in clinical diagnosis.
Resilience, self‐efficacy and diabetes distress on self‐management behaviours in patients newly diagnosed with type 2 diabetes: A moderated mediation analysis
Authors: Wang Ruey‐Hsia , Chen Shi‐Yu , Lee Chun‐Ming , Lu Chieh‐Hua , Hsu Hui‐Chun 
Published: November 2022

AbstractAimTo examine (1) the mediating role of self‐efficacy between resilience and self‐management behaviours and (2) the moderating role of diabetes distress on the relationship between self‐efficacy and self‐management behaviours in patients newly diagnosed with type 2 diabetes.DesignCross‐sectional design.MethodsTotally, 195 patients newly diagnosed with type 2 diabetes for more than 5 months but less than 18 months were recruited from three endocrine clinics in Taiwan through convenience sampling. Self‐reported questionnaires including demographic and disease characteristics, resilience, self‐efficacy and self‐management behaviours were used to collect data from October 2020 to May 2021. Moderated mediation analysis was performed by Hayes's PROCESS macro.ResultAccording to bootstrapping results, the indirect effect of resilience on self‐management was significant, although the direct effect of resilience on self‐management was not. Participants were categorized into with and without diabetes distress groups. The results of moderated mediation analysis indicated self‐efficacy significantly correlated with self‐management behaviours in participants without diabetes distress, although self‐efficacy did not significantly correlate with self‐management in participants with diabetes distress.ConclusionThe association of resilience with self‐management behaviours was fully mediated through self‐efficacy with diabetes distress moderating the relationship between self‐efficacy and self‐management behaviours in patients newly diagnosed with type 2 diabetes.ImpactImproving resilience could enhance self‐efficacy leading to possible improvement in self‐management behaviour, although improving self‐efficacy might not benefit self‐management behaviours for those with high levels of diabetes distress. Healthcare providers need to first assess and address the diabetes distress before intervening to improve self‐efficacy to enhance self‐management behaviours in patients newly diagnosed with type 2 diabetes.Patient or Public ContributionWhen designing this study, two patients newly diagnosed with diabetes were consulted about the importance of self‐management behaviours for them personally.
Cost‐effective approaches for acrylamide mitigation in high‐temperature‐processed tuber snacks
Authors: Varma Kavya , John Jenny Ann 
Published: November 2022

AbstractAcrylamide is a potential carcinogen produced at higher temperatures while frying, roasting and baking. Starch‐rich foods like potatoes are known to produce acrylamide in increasing concentrations than other kinds of foods. This study focuses on mitigation of acrylamide in sweet potato, taro and cassava samples subjected to various heat‐treatment processes like oil frying, air frying and baking. Dipping of tuber slices in solutions of garlic, green tea, sodium chloride, yeast, distilled water, whey and blanching prior to frying the tubers were found to be effective pre‐treatment methods. However, the effect of the treatments depended on the sample and mode of processing. Yeast was found to produce a significant reduction in the acrylamide production in taro (98.64%) and garlic pretreatment reduced acrylamide in deep fat fried cassava samples up to 95.62%. Similarly, air fried taro samples dipped in distilled water was found to significantly reduce the browning reaction up to 96.51%; primarily due to the fact that distilled water was found to block the reaction between precursors like asparagine and reducing sugars, thereby preventing the formation of acrylamide. Influence of reducing sugar on the formation of acrylamide, when fried at different temperatures was analyzed using Response Surface Methodology (RSM), clearly indicating that the amount of reducing sugars decreased at higher temperatures with increase in acrylamide content. The attempts in the study clearly shows that simple and cost effective pretreatments can be successful applied to produce healthy tuber products with reduced concentration of acrylamide.Practical applicationsFried foods are popular among all age groups. However, the acrylamide produced during its processing is a carcinogen of serious concern. Mitigation of this component is an urgent need. The tested simple and cost‐effective pre‐treatment methods can be applied for acrylamide mitigation in ready‐to‐eat food processing sector. Moreover these can be practically used by street‐food vendors to prepare healthier and safer processed snack foods.
Evaluation of a training program for emergency medical service physician dispatchers to reduce emergency departments visits
Authors: Foucaud Amandine , Gilbert Thomas , Vincent Adélaïde , Jomard Nathalie , Comte Brigitte , Porthault Sylvie , Comte Gaële , Theurey Odile , Gueugniaud Pierre‐Yves , Bourelly Laura , Rabilloud Muriel , Boutitie Florent , Douplat Marion , Tassa Ouazna , Haesebaert Julie , Termoz Anne , Schott Anne‐Marie 
Published: November 2022

AbstractBackgroundEmergency Departments (ED) have seen an increasing number of older patients who are mostly referred following a call to the Emergency Medical Services (EMS). Long waiting times in settings, which are not designed to meet older patients' needs, may increase the risk of hospital‐acquired complications. Unnecessary visits should therefore be avoided as much as possible. The objective of the study was to evaluate whether a program to provide geriatric knowledge and tools to the dispatching physicians of the EMS could decrease ED referrals of older patients.MethodsDesign: Before‐and‐after study with two 6‐month periods before and after intervention.Participants: All calls received by a dispatching physician of the Rhône EMS from 8 am to 6 pm concerning patients aged 75 years or above during the study period.Intervention: A program consisting of training dispatching physicians in the specific care of older patients and the developing, with a multidisciplinary team, of specific tools for dispatching physicians.Outcome: Proportion of ED referrals of patients aged 75 years or above after a call to the EMS.ResultsA total of 2671 calls to the Rhône EMS were included corresponding to 1307 and 1364 patients in the pre‐and post‐intervention phases, respectively. There was no significant difference in the proportion of referrals to the ED between the pre‐intervention (61.7%) and the post‐intervention (62.8%) phases (p = 0.57). Contact of the patients with their General Practitioner (GP) in the month preceding the call was associated with a 22% reduced probability of being referred to an ED.ConclusionsNo beneficial effect of the intervention was demonstrated. This strategy of intervention is probably not effective enough in such time‐constraint environment. Other strategies with a specific parallel dispatching of geriatric calls by geriatricians should be tested to avoid these unnecessary ED referrals.Trial registration: ClinicalTrials NCT02712450.
Effective Firm Alignment with SIGEL Crises: The Temporal Mindsets of Decision Makers
Authors: Pérez‐Nordtvedt Liliana , Shin Kilho , Lee Joohan 
Published: November 2022

AbstractWhen COVID‐19 hit, a surprising, intractable, global, existential, and lingering (SIGEL) crisis was unleashed, creating challenges unknown to humankind. To avoid failure, firms’ realignment to fit this SIGEL crisis became necessary. Yet, not all firms realigned. Why? Because of these firms' decision makers' temporal mindsets or their interpretative lenses about time. Contrary to the assumption that fast crisis response is essential, we argue and find that decision makers' time urgency (i.e., innate self‐imposed pressure to act quickly) hinders their firms' effective alignment. While past focus (i.e., innate tendency to attend to the past) had ‘o effect on effective firm alignment, present focus (i.e., innate tendency to attend to the present) and future focus (i.e., innate tendency to attend to the future) had a positive effect. Interestingly, data show that the co‐existence of (1) high future, low present, and low past and (2) high future, high present, and high past foci in decision makers' minds drive the most effective firm alignment, but (3) low future, low present, and low past foci drive the least. Using US and UK panel data, we show, conceptually and empirically, the importance of temporal mindsets to firm alignment with SIGEL crises.