bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of homocysteine and polymorphism of methylenetetrahydrofolate reductase with early-onset post stroke depression
Authors: Zhang Jingyuan , Zeng Chang , Huang Xia , Liao Qiao , Chen Hengshu , Liu Fan , Sun Dongren , Luo Shihang , Xiao Yeqing , Xu Weiye , Zeng Danfeng , Song Mingyu , Tian Fafa 
Published: December 2022

BackgroundHomocysteine (Hcy) has been indicated to be involved in pathophysiology of post stroke depression (PSD). There is a lack of research to study the relationship between Hcy metabolism genes and PSD. Our study aims to investigate the relationship among Hcy metabolism genes, Hcy, and early-onset PSD.Materials and methodsWe recruited 212 patients with stroke and collected their peripheral blood sample, clinical data, and laboratory test on admission. 12 single nucleotide polymorphisms (SNPs) in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), and methionine synthase (MTR) genes were genotyped by high-resolution melt analysis. PSD was diagnosed by DSM-V at 2 weeks after stroke. Binary logistic regression and haplotype analysis were used to examine the association between Hcy metabolism genes and PSD. Mediation analysis was performed to clarify whether the SNPs exerted their effect on PSD by affecting the Hcy level.Results81 patients were diagnosed with PSD, and the incidence rate was 38.2%. Hcy level in PSD group was significantly higher than it in non-PSD group (p = 0.019). MTHFR rs1801133 AA genotype an A allele were associated with an elevated risk of PSD after adjustment for some confounding factors (OR = 4.021, 95% CI: 1.459∼11.080, p = 0.007 for AA genotype; OR = 1.808, 95% CI: 1.172∼2.788, p = 0.007 for A allele). Furthermore, the effect of MTHFR rs1801133 AA genotype on PSD was mediated by Hcy (OR = 1.569, 95% CI: 0.013∼3.350, p &lt; 0.05).ConclusionMTHFR rs1801133 and Hcy were associated with PSD, and MTHFR rs1801133 may exert an effect on PSD via mediating Hcy level. This offers a new perspective for treating PSD and understanding the mechanism of PSD.
An updated clinical prediction model of protein-energy wasting for hemodialysis patients
Authors: Chen Si , Ma Xiaoyan , Zhou Xun , Wang Yi , Liang WeiWei , Zheng Liang , Zang Xiujuan , Mei Xiaobin , Qi Yinghui , Jiang Yan , Zhang Shanbao , Li Jinqing , Chen Hui , Shi Yingfeng , Hu Yan , Tao Min , Zhuang Shougang , Liu Na 
Published: December 2022

Background and aimProtein-energy wasting (PEW) is critically associated with the reduced quality of life and poor prognosis of hemodialysis patients. However, the diagnosis criteria of PEW are complex, characterized by difficulty in estimating dietary intake and assessing muscle mass loss objectively. We performed a cross-sectional study in hemodialysis patients to propose a novel PEW prediction model.Materials and methodsA total of 380 patients who underwent maintenance hemodialysis were enrolled in this cross-sectional study. The data were analyzed with univariate and multivariable logistic regression to identify influencing factors of PEW. The PEW prediction model was presented as a nomogram by using the results of logistic regression. Furthermore, receiver operating characteristic (ROC) and decision curve analysis (DCA) were used to test the prediction and discrimination ability of the novel model.ResultsBinary logistic regression was used to identify four independent influencing factors, namely, sex (P = 0.03), triglycerides (P = 0.009), vitamin D (P = 0.029), and NT-proBNP (P = 0.029). The nomogram was applied to display the value of each influencing factor contributed to PEW. Then, we built a novel prediction model of PEW (model 3) by combining these four independent variables with part of the International Society of Renal Nutrition and Metabolism (ISRNM) diagnostic criteria including albumin, total cholesterol, and BMI, while the ISRNM diagnostic criteria served as model 1 and model 2. ROC analysis of model 3 showed that the area under the curve was 0.851 (95%CI: 0.799–0.904), and there was no significant difference between model 3 and model 1 or model 2 (all P &gt; 0.05). DCA revealed that the novel prediction model resulted in clinical net benefit as well as the other two models.ConclusionIn this research, we proposed a novel PEW prediction model, which could effectively identify PEW in hemodialysis patients and was more convenient and objective than traditional diagnostic criteria.
Predicting the probability of pT3 or higher pathological stage at radical prostatectomy: COVID19-specific considerations
Authors: Nocera Luigi , Stolzenbach Lara F. , Collà Ruvolo Claudia , Wenzel Mike , Wurnschimmel Christoph , Tian Zhe , Gandaglia Giorgio , Fossati Nicola , Mirone Vincenzo , Chun Felix K. H. , Shariat Shahrokh F. , Graefen Markus , Saad Fred , Montorsi Francesco , Briganti Alberto , Karakiewicz Pierre I. 
Published: December 2022

BackgroundWe tested whether a model identifying prostate cancer (PCa) patients at risk of pT3-4/pN1 can be developed for use during COVID19 pandemic, in order to guarantee appropriate treatment to patients harboring advanced disease patients without compromising sustainability of care delivery.MethodsWithin the Surveillance, Epidemiology and End Results database 2010-2016, we identified 27,529 patients with localized PCa and treated with radical prostatectomy. A multivariable logistic regression model predicting presence of pT3-4/pN1 disease was fitted within a development cohort (n=13,977, 50.8%). Subsequently, external validation (n=13,552, 49.2%) and head-to-head comparison with NCCN risk group stratification was performed.ResultsIn model development, age, PSA, biopsy Gleason Grade Group (GGG) and percentage of positive biopsy cores were independent predictors of pT3-4/pN1 stage. In external validation, prediction of pT3-4/pN1 with novel nomogram was 74% accurate versus 68% for NCCN risk group stratification. Nomogram achieved better calibration and showed net-benefit over NCCN risk group stratification in decision curve analyses. The use of nomogram cut-off of 49% resulted in pT3-4/pN1 rate of 65%, instead of the average 35%.ConclusionThe newly developed, externally validated nomogram predicts presence of pT3-4/pN1 better than NCCN risk group stratification and allows to focus radical prostatectomy treatment on individuals at highest risk of pT3-4/pN1.
Hypothermia in neonates born by caesarean section at a tertiary hospital in South Africa
Authors: Patel Mariambibi , Ramagaga Neo , Kruger Danielle , Lehnerdt Grace , Mansoor Imraan , Mohlala Lesedi , Rendel Dylan , Zaheed Fathima , Jordaan Mimie , Mokhachane Mantoa , Nakwa Firdose Lambey , Mphahlele Ramatsimele 
Published: December 2022

Introductionneonatal hypothermia has previously been noted in a large proportion of neonates born through Caesarean section at Chris Hani Baragwanath Hospital (CHBAH), yet no study in South Africa specifically explores the extent and severity of the threat of hypothermia to this population of neonates.Objectivesto describe the proportion and severity of neonatal hypothermia in infants born via Caesarean section at CHBAH as well as to document and describe possible contributing factors to neonatal hypothermia in this population.MethodsA neonatal unit's database records were reviewed for demographic information of patients and their mothers, clinical characteristics, body temperature and outcomes. Comparisons between normothermic and hypothermic neonates were performed.ResultsForty-one percent of neonates born via Caesarean section had hypothermia at birth, of whom 71%, 27% and 2% had mild, moderate and severe hypothermia, respectively. Prevalence of admission hypothermia was 42%. On average, neonates were born at term and were of normal birth weight. No maternal factors were found to be statistically significant. Bag-mask ventilation (BMV) and cardiopulmonary resuscitation (CPR) [3.4% vs. 0.7%, p-0.033; OR 2.67 (95% CI: 1.06–6.77)] and an elevated lactate [13.25 vs. 3.2 mmol/l, p-0.032; OR 1.13 (95% CI: 1.01–1.26)] were associated with hypothermia. In the multivariable logistic regression analysis hypothermia in neonates was associated with an elevated lactate.ConclusionsPrevalence of hypothermia in neonates born by Caesarean section is high and further prospective studies are required to elucidate the factors contributing to this.
Exogenous melatonin treatment reduces postharvest senescence and maintains the quality of papaya fruit during cold storage
Authors: Wang Dengliang , Randhawa Mazhar Saeed , Azam Muhammad , Liu Hongru , Ejaz Shaghef , Ilahy Riadh , Qadri Rashad , Khan Muhammad Imran , Umer Muhammad Ali , Khan Muhammad Arslan , Wang Ke 
Published: December 2022

IntroductionExogenous melatonin (EMT) application has been used to reduce postharvest senescence and improve the quality and antioxidant enzyme activities of papaya fruits during cold storage.MethodsThe effects of exogenous melatonin application (1. 5 mM) were investigated on papaya fruits during cold storage (10°C ± 2°C) for 28 days in the present study.Results and discussionThe EMT treatment delayed postharvest senescence significantly with lower maturing status compared with untreated papaya fruits (control). In addition, EMT treatment maintained substantially higher titratable acidity values and ascorbic acid content but significantly lower soluble solids content and lower weight loss compared with the untreated fruits. Concerning the antioxidant capacity, the EMT-treated papaya fruit exhibited markedly higher total phenolic content and, consequently, higher DPPH-radical scavenging activity than the control group. The EMT treatment not only kept a higher enzyme activity of superoxide dismutase, peroxidase, and catalase but also significantly inhibited the accumulation of hydrogen peroxide and malondialdehyde, along with satisfying sensory attributes.ConclusionThe findings of this study indicated that EMT application could be commercially used as an eco-friendly strategy to reduce postharvest senescence and maintain the fresh-like quality traits of papaya fruit during cold storage.
Efficacy of Pythium oligandrum on improvement of lucerne yield, root development and disease score under field conditions
Authors: Pisarčik Martin , Hakl Josef , Szabó Ondřej , Nerušil Pavel 
Published: December 2022

IntroductionBiological control of root diseases of lucerne (Medicago sativa L.) has potential benefits for stand performance but this remains unsupported by evidence from practical field studies.MethodsIn field experiments at three sites our objectives were to determine the effect of Pythium oligandrum, as spring, autumn and intensive regime treatments on (i) lucerne plant density and root traits development, and (ii) forage yield and forage traits. Lucerne stands were managed under two or three treatments: non-treated control and P. oligandrum applied at two intensities of application under four-cut utilization.Results and discussionUnder relatively dry conditions (annual mean 10°C and &lt;500 mm precipitation) lucerne dry matter yield was significantly reduced by 6%, which could be related to mechanisms of inappropriate stimulation and disturbance of the balance between auxins and ethylene. Under annual precipitation of &gt;500 mm, positive impacts on stand height or fine root mass were observed for the autumn and intensive treatments where positive root response was visible only in alluvial soil. However, these changes did not result in higher yield and probably more applications per year will be needed for significant forage yield improvement. This study highlights the limits of field-scale biological control in which the potential of P. oligandrum for lucerne productivity improvement was realised only under a humid environment or deep alluvial soils, where higher root disease infestation may also be expected.
Impacting employees’ and managers’ mental health skills using a workplace-adapted mindfulness-based intervention
Authors: Bonde Emilie Hasager , Mikkelsen Eva Gemzøe , Fjorback Lone Overby , Juul Lise 
Published: December 2022

BackgroundDuring the past decades, the mental health of the population has been declining. Mindfulness-based stress reduction (MBSR) has been found effective in enhancing well-being along with reducing perceived stress and symptoms of anxiety and depression. Mindfulness-based interventions (MBIs) in the workplace have shown promising results relating to the mental health of employees and managers. However, the research field of organizational-level MBIs being offered to entire companies is still nascent. Practicing mindfulness may affect skills related to good mental health. Thus, the objective of this study was to investigate the impact of an organizational-level MBI on the mental health skills of employees and managers.MethodsThis qualitative study was part of a quasi-experimental multi-method study. Four small and medium-sized private enterprises with a total of 368 employees and managers were included. The intervention contained: 1. An obligatory introductory session on mental health and mindfulness, 2. Voluntary participation in a 10-week live online workplace-adapted MBSR course, and 3. A workshop for selected employee representatives and managers on further implementation of mindfulness in the organization. A total of 27 focus group interviews including 76 respondents were conducted pre- and post-intervention. Verbatim transcription was performed. Data was analyzed using inductive qualitative content analysis.ResultsThrough analysis, four pre-intervention categories emerged: 1. Bodily sensations and awareness in stressful situations, 2. Reactive and passive behavior during stressful situations, 3. Differences in perception as a stressor, 4. Self-criticism and low ability to practice self-care. Six post-intervention categories were identified: 1. Enhanced ability to be aware in the present moment, 2. Increased acknowledgement of how others may view things differently from oneself, 3. Increased kindness to oneself and being able to practice self-care, 4. Moving from reactive to responsive behavior in stressful situations, 5. Mindfulness as an accelerator for an ongoing personal process and 6. Practicing mindfulness – setting time aside or being mindful in everyday life.ConclusionThis study indicates that it is possible to enhance employees’ and managers’ mental health skills using an organizational-level MBI. Enhanced awareness in the present moment transcended through post-intervention categories, facilitating increased self-kindness and responsive behavior in stressful situations.
Bibliometric analysis study on cognitive function in developmental coordination disorder from 2010 to 2022
Authors: Ji Zhiguang , Wang Liyan , Cai Ming , Lu Le , Wang Hongbiao 
Published: December 2022

ObjectiveTo identify the research hotspots on cognitive function in developmental coordination disorder (DCD) in recent years, predict the research frontier and development trend, and provide more perspectives for the study of the DCD population.MethodsUsing CiteSpace and VOSviewer software to draw charts, 1,082 pieces of literature about DCD and cognitive function in the Web of Science core collection database from 2010 to 2022 were visually analyzed.Results and conclusionInterest in the cognitive function of DCD has been on the rise in the past 10 years. Over 40 countries and regions, 117 institutions and 200 researchers have participated in the corresponding research, mainly in the United States, and their institutions have published more highly influential results. The hot keywords are DCD, children, attention, working memory, performance, and attention-deficit/hyperactivity disorder (ADHD), and the main research hot topics include functional performance, population, cognitive psychology. The research directions include “DCD,” “Asperger syndrome,” “memory,” “infant,” “clumsiness,” “neurodevelopmental disorder,” “occupational therapy,” “preschool children,” “motor competence,” “model,” and “online control.” Future research should focus on motor imagery and intrinsic models and use more neurophysiological techniques to reveal the cognitive characteristics of children with DCD and develop intervention programs.
Development of a nurse-manager dualistic intervention program to alleviate burnout among nurses based on the appreciative inquiry
Authors: Guo Yu-Fang , Wang Xin-Xin , Yue Fang-Yan , Sun Feng-Ye , Ding Min , Jia Yan-Nan 
Published: December 2022

AimsTo develop a feasible and effective nurse-manager dualistic intervention program to support nurses coping with burnout symptoms.BackgroundPerson-organization combined interventions were recommended as the most effective approach for reducing burnout symptoms. However, few interventions have been developed in the nursing field.MethodsThe Medical Research Council, United Kingdom (MRC UK), Framework for Development and Evaluation of Complex Interventions, was employed for nurse-manager dualistic intervention program development. The following three steps were followed for developing the dualistic intervention program: (1) identifying the evidence base by conducting extensive reviews of the relevant literature and a mixed study; (2) identifying/developing a theory by selecting the job demands-resources model and proposing the theoretical framework for intervention development; and (3) modifying the process and outcomes of the nurse-manager dualistic intervention program.ResultsThe intervention program consists of six group sessions over 9 weeks. Researchers/managers are supposed to deliver the program. The main contents of the intervention are (1) inception (session 1); (2) discovery (session 2); (3) dream (session 3); (4) design (session 4); (5) destiny (session 5); and (6) keep (session 6). The emphasis of the intervention is on helping nurses dealing with burnout symptoms.ConclusionFollowing the guidance of the MRC framework, a feasible and potentially effective nurse-manager dualistic intervention program was developed for nurses coping with burnout. Future studies are needed to model the intervention and assess the effects and replicability of the intervention.
Epidemiology of birth defects in teenage pregnancies: Based on provincial surveillance system in eastern China
Authors: Chen Xinning , Lou Haifeng , Chen Lijin , Muhuza Marie Parfaite Uwimana , Chen Danqing , Zhang Xiaohui 
Published: December 2022

BackgroundHealthcare for adolescents and birth defects (BD) prevention are highlighted public health issues. The epidemiology of birth defects in teenage pregnancies has not been studied extensively.ObjectivesTo investigate the prevalence trend and spectrum of BDs among teenage mothers.MethodsThis observational study covered all births registered in the BD surveillance system in Zhejiang Province, China, during 2012–2018. The annual change in the prevalence of BDs among adolescent mothers was estimated. Crude relative ratios using the BD categories in teenage pregnancies were calculated and compared with those in women aged 25–29 years.ResultsOverall, 54,571 BD cases among 1,910,977 births were included in this study, resulting in an overall prevalence of 234.64 to 409.07 per 10,000 births from 2012 to 2018 (Ptrend &lt; 0.001) in total population. The prevalence of birth defects in teenage pregnancies increased from 247.19 to 387.73 per 10,000 births in 2012–2018 (Ptrend = 0.024). The risks of neural tube defects (relative risk [RR] = 3.15, 95% confidence interval [CI] 2.56, 3.87), gastroschisis (RR = 7.02, 95% CI 5.09, 9.69), and multiple birth defects (RR=1.27, 95% CI 1.07, 1.52) were higher in teenage pregnancies than those in women aged 25–29 years.ConclusionsWe found a distinctive spectrum of BDs, with higher proportions of fatal or multiple anomalies in infants born to teenage mothers than in those born to adults aged 25–29 years. These results emphasize the importance of providing adolescents with better access to reproductive and prenatal care.
Global trends and frontiers of research on pathologic myopia since the millennium: A bibliometric analysis
Authors: Yang Jingyuan , Wu Shan , Zhang Chenxi , Yu Weihong , Dai Rongping , Chen Youxin 
Published: December 2022

Background and purposePathologic myopia (PM) is an international public health issue. This study aimed to analyze PM research trends by reporting on publication trends since 2000 and identifying influential journals, countries, authors, and keywords involved in PM.MethodsA bibliometric analysis was performed to evaluate global production and development trends in PM since 2000 and the keywords associated with PM.ResultsA total of 1,435 publications were retrieved. PM has become a fascinating topic (with relative research interest ranging from 0.0018% in 2000 to 0.0044% in 2021) and a global public health issue. The top three countries with the highest number of publications were China, the USA, and Japan. The journals, authors, and institutions that published the most relevant literature came from these three countries. China exhibited the most rapid increase in the number of publications (from 0 in 2000 to 69 in 2021). Retina published the most papers on PM. Kyoko Ohno-Matsui and Tokyo Medical and Dental University contributed the most publications among authors and institutions, respectively. Based on keyword analysis, previous research emphasized myopic choroidal neovascularization and treatment, while recent hotspots include PM changes based on multimodal imaging, treatment, and pathogenesis. Keyword analysis also revealed that deep learning was the latest hotspot and has been used for the detection of PM.ConclusionOur results can help researchers understand the current status and future trends of PM. China, the USA, and Japan have the greatest influence, based on the number of publications, top journals, authors, and institutions. Current research on PM highlights the pathogenesis and application of novel technologies, including multimodal imaging and artificial intelligence.