bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rock Unloading Failure Precursor Based on Acoustic Emission Parametric Fractal Characteristics
Authors: Yang Rui , Jiakun Lv , Zhou Bo , Ma Depeng 
Published: May 2022

Abstract
The mechanical response characteristics and occurrence mechanism of coal and rock under unloading conditions are key to evaluating the stability and control of engineering rock excavation. Triaxial unloading confining pressure tests of coal and rock based on different unloading rates and different initial confining pressure conditions were conducted with fractal theory, research into the fractal characteristics of coal and rock acoustic emission time series under an unloading confining pressure, and the correlations with the unloading failure of coal and rock. The correlation dimension of the acoustic emission signal showed a variation law of a sudden increase, followed by a decrease, increase, and continuous decrease during the experiment. The average time differences between the time when the correlation dimension of coal and sandstone decreased and the actual fracture time of the rock sample were 13.6 s and 16.7 s, respectively. The change in correlation dimension showed the change in internal damage and fracture of the rock sample during the test. The HURST exponent of the acoustic emission time series was calculated at the beginning of the loading. The HURST index showed an overall stable trend and fluctuated around 0.5. A sudden drop in the HURST index resulted when the axial load reached 85% of the peak stress of the rock sample. When the HURST index dropped suddenly (minimum less than 0.2) and then increased rapidly (maximum above 0.8), the rock sample was close to rupture. A HURST index of 0.8 can be used as an index of rock sample unloading and fracture.
Physiologically-Based Pharmacokinetic Model for Pulmonary Disposition of Protein Therapeutics in Humans
Authors: Jagdale Prabhas , Sepp Armin , Shah Dhaval K. 
Published: May 2022

Abstract
Lung related disorders like COPD and Asthma, as well as various infectious diseases, form a major therapeutic area which would benefit from a predictive and adaptable mathematical model for describing pulmonary disposition of biological modalities. In this study we fill that gap by extending the cross-species two-pore physiologically-based pharmacokinetic (PBPK) platform with more detailed respiratory tract that includes the airways and alveolar space with epithelial lining fluid. We parameterize the paracellular and FcRn-facilitated exchange pathways between the epithelial lining fluid and lung interstitial space by building a mechanistic model for the exchange between the two. The optimized two-pore PBPK model described pulmonary exposure of several systemically dosed mAbs for which data is available and is also in agreement with the observed levels of endogenous IgG and albumin. The proposed framework can be used to assess pharmacokinetics of new lung-targeting biologic therapies and guide their dosing to achieve desired exposure at the pulmonary site-of-action.
Reabilitação Respiratória para pacientes submetidos à cirurgia torácica e abdominal
Authors: Nunes Simony Fabíola Lopes , Pascoal Lívia Maia , Lima Neto Pedro Martins , Santos Francisco Dimitre Rodrigo Pereira , Goiabeira Yara Nayá Lopes de Andrade , Santana Anderson Gomes Nascimento 
Published: May 2022

Objetivo: descrever a experiência relacionada a reabilitação respiratória para pacientes submetidos à cirurgia torácica e abdominal superior durante a execução de um programa de extensão universitária. Método: relato de experiência, com abordagem descritiva, sobre a criação de um programa interdisciplinar de reabilitação respiratória para pacientes submetidos à cirurgia torácica e abdominal superior com parceria entre universidade pública e hospital municipal de Imperatriz, Maranhão. Resultados: as atividades do programa universitário de reabilitação respiratória para pacientes em pós-operatório são desempenhadas em três eixos in locus: Educação em Exercícios Respiratórios, Capacitação sobre assistência de enfermagem no pós-operatório de cirurgias torácicas e abdominais e, Educação em saúde e intervenções de enfermagem na atenção ao paciente no período pós-operatório. Conclusão: a atuação em projeto respiratório interdisciplinar, focado em ações educativas, mostrou-se uma ferramenta inovadora de apoio ao cuidado clínico de pacientes submetidos à cirurgia torácica e abdominal superior.
Can we Succeed in the Fight Against SARS-CoV-2 with its Emerging New Variants?
Authors: Tavakol Shima , Tavakol Hani , Alavijeh Mo S. , Seifalian Alexander 
Published: May 2022

Abstract:
In 2019, the whole world came together to confront a life-threatening virus named SARS-CoV-2,
causing COVID-19 illness. The virus infected the human host by attaching to the ACE2 and CD147 receptors
in some human cells, resulting in cytokine storm and death. The new variants of the virus that caused concern
are Alpha, Beta, Gamma, Delta, and Epsilon, according to the WHO label. However, Pango lineages designated
them as B.1.1.7, B.1.351, P.1, B.1.617.2, and B.1.429. Variants may be progressively formed in one chronic
COVID-19 patient and transmitted to others. They show some differences in cellular and molecular mechanisms.
Mutations in the receptor-binding domain (RBD) and N-terminal domain (NTD) lead to alterations in
the host's physiological responses. They show significantly higher transmissibility rates and viral load while
evading neutralizing antibodies at different rates. These effects are through mutations, deletion, and conformational
alterations in the virus, resulting in the enhanced affinity of RBD to PD of ACE2 protein, virus entry, and
spike conformational change. In the clinical laboratory, new variants may diagnose from other variants using
specific primers for RBD or NTD. There are some controversial findings regarding the efficacy of the developed
vaccines against the new variants. This research aimed to discuss the cellular and molecular mechanisms
beyond COVID-19 pathogenesis, focusing on the new variants. We glanced at why the mutations and the ability
to transmit the virus increase and how likely the available vaccines will be effective against these variants.
Green Polymer Nanocomposites in Automotive and Packaging Industries
Authors: Susan Md. Abu Bin Hasan , Harun-Ur-Rashid Mohammad , Imran Abu Bin 
Published: May 2022

Abstract:
Green polymer nanocomposites referred to as completely biodegradable, renewable, environmentally
friendly, and benign materials, have received a surge of attention to promote sustainable
development. Polymer nanocomposites, where nanomaterials are used for reinforcement, possess a
large interfacial area per volume, and the intervals between the filler nanoparticles and polymer matrix
are significantly short. Molecular interactions between the filler particles and the matrix, therefore,
provide polymer nanocomposites with novel characteristics that ordinary polymers or conventional
macrocomposites do not possess. However, nanoparticles, nanotubes, nanofilms, nanofibers,
nanoflakes, etc., in the form of nanocomposites may cause serious health hazards and pollute the
environment severely. While the number of review articles on fundamental and applied research
work of polymer nanocomposites is noteworthy, this review focuses more in depth on the applications
of safe and green polymer nanocomposites in the automotive and packaging industries. The
particular focus has been to examine and investigate in detail the initial and contemporaneous trends,
status, and perspectives of green and safe polymer nanocomposites in the automotive and packaging
industries. Background characteristics, strengths, weaknesses, potentiality, prospects, and opportunities
of green polymer nanocomposites suitable for automotive and packaging industries have been
addressed. The ultimate goal is to have a profound understanding of the structure-property relationship
of green polymer nanocomposites to overcome existing limitations for automotive and packaging
applications.
A Multi-dimensional Review on Severe Acute Respiratory Syndrome
Coronavirus-2
Authors: Ghosh Ketan , Chattopadyay Bumba , Maity Tapas , Acharya Ayan 
Published: May 2022

Abstract:
The advent and spread of novel coronavirus (nCoV) has posed a new public health crisis
since December 2019. Several cases of unexplained pneumonia occurred in Wuhan, Hubei
Province, China, only a month before the Chinese Spring festival. After the diagnosis of bronchoalveolar
fluid samples of people infected, the new coronavirus was identified using nextgeneration
sequence technology. This work aims to provide information regarding COVID-19
that will help the researchers to identify the vital therapeutic targets for SARS-CoV-2 and also
will provide insights into some significant findings of recent times highlighted by scientific communities
around the globe. In this review, we have tried to explore multiple aspects related to
COVID-19, including epidemiology, etiology, COVID-19 variants, vaccine candidates, potential
therapeutic targets, the role of natural products, and computational studies in drug design and development,
repurposing, and analysis of crystal structures available for COVID-19 related protein
structures. Druggable targets include all viral enzymes and proteins involved in viral replication
and regulation of host cellular machines. The medical community tracks several therapies to combat
the infection by investigating various antiviral and immunomodulatory mechanisms. While
some vaccines are approved in this worldwide health crisis, a more precise therapy or drug is formally
recommended to be used against SARS-CoV-2 infection. Natural products other than synthetic
drugs have been tested by in silico analysis against COVID-19. However, important issues
still need to be addressed regarding in vivo bioavailability and better efficacy.
Water Purification by Green Synthesized Nanomaterials
Authors: Singh N.B. , Anindita De  , Guin Mridula , Barthwal Sumit 
Published: May 2022

Background:Water pollution is one of the leading causes for human fatality in the world particularly in underdeveloped or in developing countries. Moreover, with rapid industrialization and urbanization of rural lands, the problem of water pollution is posing a severe threat to communal health and livelihood these days. The pollutants found in water are of varied nature and depends on the source of the water. Several techniques have been so far adapted to purify contaminated water which includes both sophisticated, costly methods and simple and cost-effective methods. All these techniques have one or more disadvantages which limit their application in large scale, sustainable and long-term usage. The advances in the field of nanoscience and technology have opened a new horizon for replacement/ improvement of these conventional ways with more efficient methods. Presently green synthesized nanomaterials are being used for water purification.Methods:Plant extracts and microbes are being used to synthesize nanomaterials which are being used as catalysts, adsorbents and membranes for water purification.Results:Nanomaterial-based techniques could create problems on the environment due to various chemicals used in their production step and thus defeating the ultimate purpose. In this regard, green nanomaterials can prove to be extremely useful both in terms of sustainability and efficiency.Conclusions:This review illustrates various ways how green nanomaterials can be utilized for water remediation and summarize the recent work done in this emerging research front.
Epilepsy and Alzheimer’s Disease: Current Concepts and Treatment
Perspective on Two Closely Related Pathologies
Authors: Citraro Rita , Leo Antonio , Tallarico Martina , Sciaccaluga Miriam , Costa Cinzia 
Published: May 2022

Abstract:
The literature on epileptic seizures in Alzheimer's disease has significantly increased over
the past decades. Remarkably, several studies suggest a bi-directional link between these two common
neurological diseases, with either condition carrying a nearly 2-fold risk of contracting the other
in comparison to healthy subjects. In this respect, evidence from both clinical and preclinical
studies indicates that epileptogenesis and neurodegeneration possibly share common underlying
mechanisms. However, the precise association between epileptogenesis and neurodegeneration still
needs to be fully elucidated. Targeted intervention to reduce abnormal network hyperexcitability
might constitute a therapeutic strategy to postpone the onset of later neurodegenerative changes and
consequent cognitive decline by many years in patients. By virtue of this, an early diagnosis and
treatment of seizures in patients with Alzheimer’s disease should be pursued. To date, no guidelines
are available for treating epileptic activity in this context, largely due to the paucity of studies sufficient
to answer the related questions. Accordingly, clinical trials are mandatory, not only to inform
clinicians about symptomatic management of seizures in Alzheimer’s disease patients but also to detect
if treatment with antiseizure medications could have disease-modifying effects. Moreover, it
will be fundamental to expand the application of animal models of Alzheimer’s disease to comorbid
conditions, such as epilepsy both to reveal the mechanisms underlying seizure onset and to better
define their role in cognitive decline. Such models could also be useful to identify pharmacological
compounds having therapeutically effectiveness as well as reliable early biomarkers for seizures in
Alzheimer’s disease.
Comparison of the Quality of Life and Post-traumatic Stress in Postmenopausal
and Non-menopausal Women after Hysterectomy in Selected Hospitals
of Shiraz University of Medical Sciences in 2020
Authors: Radmehr Zohreh , zarshenas Mahnaz , keshavarz Maryam , Akbarzadeh Marzieh 
Published: May 2022

Background:
Hysterectomy is one of the most common gynecological surgeries that affect
women's mental health and quality of life.

Objective:
This study aimed to investigate the correlation between the quality of life and posttraumatic
stress in hysterectomized postmenopausal and non-menopausal women.

Materials and Methods:
This cross-sectional analytical study was conducted from August to December
2019 on hysterectomies postmenopausal and non-menopausal women. There were 77 subjects
in each group with a mean age of 52.55 ± 1.098. They were selected via convenience sampling
at Hazrat Zeinab (PBUH) and Shahid Dr. Faghihi Hospitals in Shiraz. They were evaluated in a
two-month follow-up using the Impact of Event Scale-Revised (Weiss & Marmar, 1997) and WHO
Quality of Life-BREF (WHOQOL-BREF) questionnaires. Data were analyzed in SPSS-16 software
using descriptive and inferential statistics (independent t-test, paired t-test, and Pearson or Spearman
correlation coefficients).

Results:
Unlike the first stage of the study (before and a week after the surgery, P = 0.289), there
was a significant negative relationship in the quality of life and post-traumatic stress between postmenopausal
and non-menopausal women (P = 0.001) in the second stage (two months after the surgery).
Hysterectomy increased the mean score of post-traumatic stress in postmenopausal and nonmenopausal
women after the surgery (P = 0.179), while the quality of life improved and stress decreased
two months later (P = 0.0001).

Conclusion:
Hysterectomy improved the quality of life in postmenopausal and significantly in nonmenopausal
women. Hence, due to the correlation and significant negative relationship between
post-traumatic stress and quality of life, midwives, families, and society need to pay attention to
women’s quality of life.
Molecular Study of Adenovirus Genotypes 40 and 41 in Children with
Acute Gastroenteritis
Authors: Essa Sara G. , Zaki Maysaa El Sayed , Elmansoury Eman A. , Hassan Rasha H. , EL Kheir Nermin Y.A. 
Published: May 2022

Background:
Adenovirus is a common virus associated with acute gastroenteritis in children.
There are certain genotypes that are prevalent in these infections, such as genotypes 40 and 41.

Objective:
The aim of the present study was to investigate the incidence of adenovirus genotypes 40
and 41 in children with acute gastroenteritis by polymerase chain reaction (PCR) and also to determine
the possibility of Adenovirus co-infections with Rotavirus.

Methods:
The study was a cross-sectional study that included 100 children with acute gastroenteritis.
The children were subjected to full history taking and clinical examination. Stool samples from the
patients were subjected to detection of adenovirus and rotavirus antigens by enzyme-linked immunosorbent
assay (ELISA) and detection of adenovirus genotypes 40 and 41 by polymerase chain reaction
(PCR).

Results:
The most prevalent virus by the used methods was rotavirus antigen in the stool (35%). Adenovirus
antigen detection was positive in 23% of the stool samples, with positive PCR for these samples
in 22%. The ADv40 was detected in 13 samples, and ADv41 was detected in 9 samples. One positive
sample by adenovirus antigen ELISA was negative by PCR for these genotypes. Mixed rotavirus
and adenovirus by ELISA were detected in 7% of the children.
In patients with positive adenovirus antigen by ELISA, the most common symptoms were vomiting
(54.5%) and abdominal pain (45.5%). An insignificant difference between fever (P=0.94) and abdominal
pain (P=0.63) was detected in children infected with adenovirus compared to patients infected
with other organisms. The adenovirus was detected in 68.2% of children with acute gastroenteritis ≤ 24
months. Vomiting was significantly increased in children with adenovirus (54.5%) compared to children
negative for adenovirus (23.1%-P=0.004, OR 4.0, 95%CI: 1.5-10.8)

Conclusion:
The study highlights the presence of adenovirus genotypes 40 and 41 in the stool of children
with acute gastroenteritis. Combined rotavirus and adenovirus infections were detected in our study.
WITHDRAWN: A Comprehensive Pharmacological Review of Some Medicinally
Significant Plants of Bangladesh with Traditional Antipsychotic
Activity
Authors: Rafe Md. Rajdoula , Rahman Mahbubur , Sutra Dhar Ananta , Kabir Imonul , Biswas Subir 
Published: May 2022

Abstract:
The article has been withdrawn from the journal Current Traditional Medicine.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.
The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Performance Analysis of Total Attenuation Effects and Different Values of
Transmitter Power on Bit Error Rate and Signal-To-Noise Ratio for Free
Space Optical Communication
Authors: Olyaee Saeed , Akbari Mahdi 
Published: May 2022

Objective:
In this paper, the performance of pulse position modulation (PPM), nonreturn
zero modulation (NRZ), and return zero modulation (RZ) at signal-to-noise ratio and bit
error rate in free space optical communication is compared. This comparison is performed to obtain
the most effective modulation in atmospheric attenuations. Also, the effect of increasing
transmitter power on the bit error rate and signal-to-noise ratio is investigated.

Methods:
Utilizing a light source with a wavelength of 1550 nm, the system is simulated in
MATLAB by choosing the Kim data transmission link model with different visibility values of 0-
10 km. The analytical equations of free space optical communications are implemented by selecting
appropriate parameters. The effects of weak, moderate, and strong atmospheric attenuation,
geometric loss, and different transmitter powers (1-5 mW) on bit error rate and signal-to-noise
ratio are investigated for all three modulations.

Results:
The results show that PPM is the most effective modulation compared to other modulations
used in this study and shows a better performance in the mentioned atmospheric attenuation
conditions within the given values of bit error rate and signal-to-noise ratio.

Conclusion:
Modulations with lower average power will perform better than other modulations in
bit error rate and signal-to-noise ratio under the same atmospheric attenuation conditions. In PPM
modulation, increasing the transmitter power causes more reduction in the bit error rate than other
modulations used in this paper. Therefore, using this modulation to optimize the power budget in
free space optical communications will be appropriate.
Improved Wasserstein Generative Adversarial Networks Defense Method
Against Data Integrity Attack on Smart Grid
Authors: Li Yuancheng , Wang Xiao , Zeng Jing 
Published: May 2022

Background:
As the integration of communication networks with power systems is
getting closer, the number of malicious attacks against the cyber-physical power system is increasing
substantially. The data integrity attack can tamper with the measurement information
collected by Supervisory Control and Data Acquisition (SCADA), which can affect important
decisions of the power grid and pose a significant threat to normal operation.

Objective:
In order to defend against the data integrity attack, and safeguard the normal operation
of the power system, we propose a defense method based on improved WGAN (Wasserstein Generative
Adversarial Networks).

Method:
Firstly, through the training of the discriminator and generator, the discriminator identifies
and eliminates the measurements damaged by the data integrity attack, and the generator uses
the temporal and spatial correlation of the power grid measurements to generate complementary
measurements which are infinitely close to the original normal data. Meanwhile, using the improved
WGAN, the training stability and the convergence speed are significantly improved, and
the quality of complementary data is much higher.

Results:
Extensive simulation experiments were carried out in the IEEE-14 and IEEE-118 standard
bus systems. By comparing the deviations between the complementary data and normal data
under different iteration times and methods, the mean squared error of the deviations with the
proposed method is greatly reduced than traditional methods. The excellent recovery performance
of the defense method based on improved WGAN is verified.

Conclusion:
A smart grid data integrity attack defense method based on improved WGAN is proposed
to detect data integrity attacks, and the experimental results demonstrate the recovery effectiveness
of the proposed method.