bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUASI KETERSEDIAAN RUANG TERBUKA HIJAU (RTH) PUBLIK PADA KAWASAN PADAT LALULINTAS (Studi Kasus : Jl. Guntur Kecamatan Garut Kota)
Authors: Hartami Ayu Sri Rahayu 
Published: June 2022

Jalan Guntur merupakan salah satu bagian dari wilayah BWK 1 yang dimana berdasarkan survei lapangan volume lalulintas Jalan Guntur mencapai 1988 smp/jam. Kondisi RTH di Jalan Guntur masih belum memenuhi kelayakan dimana RTH di kawasan tersebut masih minim. MetodeÂ yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Metode pengumpulan data yaitu didapat dariÂ hasil observasi lapangan dan ditunjang dengan data dari instansi - instansi terkait. Jalan Guntur merupakan kawasan jalan dengan keadaan lalulintas yang selalu padat, Lalulintas Harian Rata â€“ rata (LHR)Â selalu meningkat karena dipengaruhi oleh laju pertumbuhan kendaraan yang selalu meningkat setiap tahunnya. Dampak dari hal tersebut adalah peningkatan kadar zat pencemar diudara ambien yang menunjukan peningkatan pula setiap tahun. Jalan Guntur termasuk kedalamÂ Jalan Lokal kelas III A dimana Kondisi RTH Jalan Guntur masih belum mencapai 20 â€“ 30%, RTH yang tersedia di Jalan Guntur baru mencapai Â± 13% sehingga perlu penambahan RTHÂ Â± 7 â€“ 17% dimana RTH ini dapat ditempatkan disepanjang trotoar Jalan Guntur dengan menempatkan pot â€“ pot tanaman di sepanjang jalan tersebut dengan jenis tanaman yang memiliki fungsi sebagai penyerap polusi udara.
Fricción de brackets autoligado y convencionales en el cierre de espacios: revisión de la literatura
Authors: González-Andrade María , Lima-Illescas Miriam 
Published: June 2022

La fricción en ortodoncia se debe al contacto entre el arco, método de ligadura y el bracket, la fricción reduce la fuerza aplicada para los movimientos dentales por lo que es necesario aplicar mayor fuerza para producir el movimiento dental, en relación al método de ligadura empleada para el deslizamiento existen diferentes mecánicas para el cierre de espacios, una de ellas es mediante la confección de ansas para producir cierre de espacios con mínima fricción conocida como mecánica no deslizante y la mecánica deslizante en la cual los brackets se deslizan a través del arco mediante el uso de resortes o cadenetas generando mayor fricción, es por ello que se introducen los brackets de autoligado, por presentar mejores ventajas en comparación con los brackets convencionales, con menor fricción, menor tiempo de trabajo, eficacia de alineación entre otros. Objetivo: Analizar la literatura actual sobre la fricción de brackets autoligado y brackets convencionales en el cierre de espacios. Metodología: Se realizó una búsqueda en las bases de datos PubMed, Scopus, Web of Science y BVS regional, después de aplicar los criterios de inclusión y exclusión se obtuvo 26 estudios que cumplieron con los parámetros establecidos para la presente revisión. Conclusión: No existe diferencia en cuanto a la fricción de brackets de autoligado en comparación con los brackets convencionales en el cierre de espacios, sin embargo, existen otras variables que muestran diferencias entre brackets de autoligado y brackets convencionales en relación al tiempo de tratamiento y la pérdida de anclaje.
IMPLEMENTASI APLIKASI E-COMMERCE UNTUK PEMBERDAYAAN HOME INDUSTRI
Authors: Hermaliani Eni Heni , Fatimah Lia , Qomariyyah Nurul 
Published: June 2022

Perkembangan teknologi yang sangat pesat secara langsung maupun tidak langsung mempengaruhi sistem perdagangan. Home Industri merupakan usaha mandiri yang bergerak dibidang penjualan dalam hal ini memproduksi boneka. Mekanisme sistem penjualan saat ini masih menggunakan sistem konvensional dalam hal pencatatan data barang dan laporan data penjualan, sehingga menyulitkan pemilik dalam memperoleh informasi yang akurat. Penelitian ini bertujuan untuk membuat aplikasi e-commerce sebagai aplikasi penjualan online yang dapat membantu masyarakat untuk mendapatkan informasi aktual seputar hasil evaluasi, pengetahuan dan kegiatan-kegiatan pada home industri. Sedangkan metode penelitian meliputi pengumpulan data berupa observasi dan wawancara. Kemudian model pengembangan sistem dengan metode pendekatan SDLC (System Deployment Life Cycle). Tujuan adanya aplikasi diharapkan dapat memberikan kemudahan kepada masyarakat untuk melakukan pembelian produk tanpa harus datang ke lokasi dan membantu home industri dalam melakukan proses promosi dan penjualan boneka secara efektif dan efisien.
PENERAPAN MODEL PROTOTIPE APLIKASI PERANGKAT LUNAK PEMESANAN AIR BERSIH PDAM TIRTA PAKUAN KOTA BOGOR
Authors: Sismadi Sismadi 
Published: June 2022

Pergantian musim penghujan ke kemarau pada suatu wilayah berbeda-beda, akibat siklus tahuanan ini menyisakan berbagai masalah terutama ketersedian air minum sebagai kebutuhan dasar keberlangsungan hidup manusia. Hal ini berdampak pada tinggi-rendahnya transaksi pembelian air minum tangki pada PDAM tirta pakuan yang terletak dikota bogor. Perusahaan air minum pemerintah ini dalam menerima pesanan transaksi pembelian air masih bersifat konvensional atau manual yang tercatat pada buku kertas biasa. Hal ini menimbulkan permasalahan diantaranya kurang akurat dalam pencatatan data pelanggan yang melakukan pemesanan, tidak standarnya akurasi informasi yang tercatat sebab setiap petugas memiliki model tulisan yang berbeda. Pada akhir bulan kesulitan dalam pembuatan laporan terutama pada musim kemarau, pesanan air minum tangki sangat tinggi. Kondisi ini harus dicarikan jalan pemecahannya. Solusi yang memungkinkan dan berbiaya rendah adalah implementasi kedalam sistem berbasis computer. Dengan sistem ini keakuratan informasi terjamin dan terstandarisasi, tidak tergantung dengan kondisi petugas, kemudahan dalam pembuatan laporan diakhir bulan teratasi. Pelanggan tetap dapat diberikan perlakuan lebih baik sehingga pendapatan instansi meningkat. Tingginya transaksi pemesanan pada musim kemarau dapat diatasi dengan baik sehingga kinerja PDAM tirta pakuan akan menjadi lebih baik dan profit perusahaan terjaga. Pada penerapan sistem pemesanan air minum tangki ini menggunakan model pengembangan perangkat lunak prototype, yang memiliki beberapa tahapan. Perancangan dapat dengan mudah disesuaikan dengan kebutuhan pelanggan dan sangat adaptif terhadap perubahan permintaan pelanggan sehingga sistem sangat ramah dan mudah dioperasikan. Model ini salah satu yang banyak digunakan pada perancangan sistem untuk skala kecil hingga menengah.
Extraction of Biocompatible Collagen From Blue Shark Skins Through the Conventional Extraction Process Intensification Using Natural Deep Eutectic Solvents
Authors: Batista Miguel P. , Fernández Naiara , Gaspar Frédéric B. , Bronze Maria do Rosário , Duarte Ana Rita C. 
Published: June 2022

The disposal of large amounts of skin waste resulting from the blue shark fishing industry presents several industrial and environmental waste management concerns. In addition, these marine subproducts are interesting sources of collagen, a fibrous protein that shows high social and economic interest in a broad range of biomedical, pharmaceutical, and cosmetic applications. However, blue shark wasted skins are a poorly explored matrix for this purpose, and conventional collagen recovery methodologies involve several pre-treatment steps, long extraction times and low temperatures. This work presents a new green and sustainable collagen extraction approach using a natural deep eutectic solvent composed of citric acid:xylitol:water at a 1:1:10 molar ratio, and the chemical characterization of the extracted collagen by discontinuous electrophoresis, thermogravimetric analysis, Fourier transformed infrared spectroscopy and circular dichroism. The extracted material was a pure type I collagen, and the novel approach presented an extraction yield 2.5 times higher than the conventional one, without pre-treatment of raw material and reducing the procedure time from 96 to 1 h. Furthermore, the in vitro cytotoxicity evaluation, performed with a mouse fibroblasts cell line, has proven the biocompatibility of the extracted material. Overall, the obtained results demonstrate a simple, quick, cheap and environmentally sustainable process to obtain marine collagen with promising properties for biomedical and cosmetic applications.
A Randomized Controlled Trial on the Efficacy of Xinnaoning Capsule in the Treatment of CSAP Complicated With Qi Stagnation and Blood Stasis Syndrome
Authors: Li Jing , Zhang Ping , Zhang Ying , Wang Haiyun , Wu Liqi , Zhao Junnan , Liu Yue , Zeng Wenying , Guo Renzhen , Mei Jun , Xu Fengqin 
Published: June 2022

ObjectiveThis study was designed to explore the efficacy and safety of Xinnaoning Capsule (XNNC) in the treatment of patients with chronic stable angina pectoris (CSAP) complicated with Qi stagnation and blood stasis syndrome.MethodsA total of 240 patients with CSAP complicated with Qi stagnation and blood stasis syndrome who met the inclusion criteria were enrolled from 8 medical centers across China. The trial treatment lasted 14 weeks, including a 2-week lead-in period and a 12-week double-blind treatment period. Patients in the experimental group were treated with XNNC, while patients in the control group were treated with placebos. Thereafter, examinations were conducted on the efficacy of angina pectoris before and after treatment and the relief of symptoms, followed by the recording of grading changes in angina severity, changes in the number of angina pectoris, and the amount of taken nitroglycerin. Finally, adverse events were assessed.ResultsCompared with the control group, the total score and the effective rate of angina pectoris were significantly increased in the experimental group, accompanied by the statistically significant improvement in the severity of angina pectoris (all p &lt; 0.05). Furthermore, there was no statistically significant difference in the adverse events and serious adverse events between the experimental group and the control group (p = 1.0000) before and after treatment.ConclusionXNNC is a safe and effective medicine for patients with CSAP complicated with Qi stagnation and blood stasis syndrome.
Catheter-Based Therapies Decrease Mortality in Patients With Intermediate and High-Risk Pulmonary Embolism: Evidence From Meta-Analysis of 65,589 Patients
Authors: Pietrasik Arkadiusz , Gąsecka Aleksandra , Szarpak Łukasz , Pruc Michał , Kopiec Tomasz , Darocha Szymon , Banaszkiewicz Marta , Niewada Maciej , Grabowski Marcin , Kurzyna Marcin 
Published: June 2022

BackgroundCatheter-directed therapies (CDT) are an alternative to systemic thrombolysis (ST) in pulmonary embolism (PE) patients, but the mortality benefit of CDT is unclear.ObjectiveWe conducted a systematic review with meta-analysis to compare the efficacy and safety of CDT and ST in intermediate-high and high-risk PE.MethodsWe included (P) participants, adult PE patients; (I) intervention, CDT; (C) comparison, ST; (O) outcomes, mortality, complications, in-hospital treatment, and length of hospital stay; (S) study design, randomized controlled trials (RCTs), or cohort comparing CDT and ST. The primary endpoint was 30-day mortality. Secondary outcomes included treatment-related complications including bleeding, the use of hospital resources, and length of hospital stay.ResultsEleven studies including 65,589 patients met the inclusion criteria. Thirty-day mortality was lower in the CDT group, compared to ST group [7.3 vs. 13.6%; odds ratio (OR) = 0.51, 95% confidence interval (CI) 0.38–0.69, p &lt; 0.001]. The rates of myocardial injury, cardiac arrest, and stroke were lower in CDT group, compared to ST group (p &lt; 0.001 for all). The rates of any major bleeding, intracranial hemorrhage, hemoptysis, and red blood cell transfusion were lower in patients treated with CDT, compared to ST (p ≤ 0.01 for all). Extracorporeal life support was used more often in patients treated with CDT, compared to ST (0.5 vs. 0.2%, OR = 2.52, 95% CI 1.88–3.39, p &lt; 0.001). The use of hospital resources and length of hospital stay were comparable in both groups.ConclusionCDT might decrease mortality in patients with intermediate-high and high-risk PE and were associated with fewer complications, including major bleeding.
Genome-Wide Identification of N6-Methyladenosine Associated SNPs as Potential Functional Variants for Type 1 Diabetes
Authors: Chen Yang , Shen Min , Ji Chen , Huang Yanqian , Shi Yun , Ji Li , Qin Yao , Gu Yong , Fu Qi , Chen Heng , Xu Kuanfeng , Yang Tao 
Published: June 2022

ObjectivesN6-methyladenosine (m6A) is essential in the regulation of the immune system, but the role that its single nucleotide polymorphisms (SNPs) play in the pathogenesis of type 1 diabetes (T1D) remains unknown. This study demonstrated the association between genetic variants in m6A regulators and T1D risk based on a case-control study in a Chinese population.MethodsThe tagging SNPs in m6A regulators were genotyped in 1005 autoantibody-positive patients with T1D and 1257 controls using the Illumina Human OmniZhongHua-8 platform. Islet-specific autoantibodies were examined by radioimmunoprecipitation in all the patients. The mixed-meal glucose tolerance test was performed on 355 newly diagnosed patients to evaluate their residual islet function. The functional annotations for the identified SNPs were performed in silico. Using 102 samples from a whole-genome expression microarray, key signaling pathways associated with m6A regulators in T1D were comprehendingly evaluated.ResultsUnder the additive model, we observed three tag SNPs in the noncoding region of the PRRC2A (rs2260051, rs3130623) and YTHDC2 (rs1862315) gene are associated with T1D risk. Although no association was found between these SNPs and islet function, patients carrying risk variants had a higher positive rate for ZnT8A, GADA, and IA-2A. Further analyses showed that rs2260051[T] was associated with increased expression of PRRC2A mRNA (P = 7.0E-13), and PRRC2A mRNA was significantly higher in peripheral blood mononuclear cell samples from patients with T1D compared to normal samples (P = 0.022). Enrichment analyses indicated that increased PRRC2A expression engages in the most significant hallmarks of cytokine-cytokine receptor interaction, cell adhesion and chemotaxis, and neurotransmitter regulation pathways. The potential role of increased PRRC2A in disrupting immune homeostasis is through the PI3K/AKT pathway and neuro-immune interactions.ConclusionThis study found intronic variants in PRRC2A and YTHDC2 associated with T1D risk in a Chinese Han population. PRRC2A rs2260051[T] may be implicated in unbalanced immune homeostasis by affecting the expression of PRRC2A mRNA. These findings enriched our understanding of m6A regulators and their intronic SNPs that underlie the pathogenesis of T1D.
Resistin Associated With Cytokines and Endothelial Cell Adhesion Molecules Is Related to Worse Outcome in COVID-19
Authors: Ebihara Takeshi , Matsumoto Hisatake , Matsubara Tsunehiro , Togami Yuki , Nakao Shunichiro , Matsuura Hiroshi , Onishi Shinya , Kojima Takashi , Sugihara Fuminori , Okuzaki Daisuke , Hirata Haruhiko , Yamamura Hitoshi , Ogura Hiroshi 
Published: June 2022

IntroductionResistin is reported to form a cytokine network and cause endothelial damage. The pathogenesis of coronavirus disease 2019 (COVID-19) remains unknown, but the association between cytokine storm and endothelial damage is crucial. This study aimed to evaluate resistin in COVID-19 pathogenesis compared with sepsis.Materials and MethodsFirst, we evaluated the association of plasma resistin levels and disease severity and clinical outcome in two large cohorts: a publicly available cohort including 306 COVID-19 patients in the United States (MGH cohort) and our original cohort including only intubated 113 patients in Japan (Osaka cohort 1). Second, to understand pathogenesis, we evaluate resistin, cytokines and endothelial cell adhesion molecules in COVID-19 compared with sepsis. Blood samples were collected from 62 ICU-treated COVID-19 patients and 38 sepsis patients on day 1 (day of ICU admission), days 2-3, days 6-8, and from 18 healthy controls (Osaka cohort 2). The plasma resistin, inflammatory cytokines (IL-6, IL-8, MCP-1 and IL-10) and endothelial cell adhesion molecules (ICAM-1 and VCAM-1) were compared between patients and control. Correlations among resistin, inflammatory cytokines and endothelial cell adhesion molecules were evaluated in COVID-19 and sepsis.ResultsIn the MGH cohort, the day 1 resistin levels were associated with disease severity score. The non-survivors showed significantly greater resistin levels than survivors on days 1, 4 and 8. In the Osaka cohort 1, 28-day non-survivors showed significantly higher resistin levels than 28-day survivors on days 6-8. Patients with late recovery (defined as the day of weaning off mechanical ventilation &gt;12 or death) had significantly higher resistin levels than those with early recovery on day 1 and days 6-8. In the Osaka cohort 2, plasma resistin levels were elevated in COVID-19 and sepsis patients compared to controls at all measurement points and were associated with inflammatory cytokines and endothelial cell adhesion molecules.ConclusionResistin was elevated in COVID-19 patients and was associated with cytokines and endothelial cell adhesion molecules. Higher resistin levels were related to worse outcome.
A Novel Overall Survival Prediction Signature Based on Comprehensive Research in Prostate Cancer Bone Metastases
Authors: Hu Konghe , Hu Xinyue , Duan Yang , Li Wenqiang , Qian Jing , Chen Junjie 
Published: June 2022

BackgroundProstate adenocarcinoma (PRAD)-related bone metastases are a leading source of morbidity and mortality; however, good diagnostic biomarkers are not known yet. The aim of this study was to identify biomarkers and prognostic indicators for the diagnosis and treatment of PRAD-associated bone metastases.MethodsBy combining the data from The Cancer Genome Atlas(TCGA) and PRAD SU2C 2019, We performed a comprehensive analysis of the expression differences, biological functions, and interactions of genes associated with PRAD bone metastasis. Annotation, visualization, and integrated discovery were accomplished through the use of gene ontology enrichment and gene set enrichment analysis. The protein-protein interaction network was constructed using the STRING database, and the diagnostic value of prognostic genes was validated using receiver-operating-characteristic and Kaplan-Meier curves.ResultsSix genes (DDX47, PRL17, AS3MT, KLRK1, ISLR, and S100A8) associated with PRAD bone metastases were identified; these had prognostic value as well. Among them, enrichment was observed for the biological processes extracellular matrix tissue, extracellular structural tissue, steroid hormone response, and cell oxidative detoxification. KEGG analysis revealed enrichment in interactions with extracellular matrix receptors, diseases including Parkinson's disease and dilated cardiomyopathy, and estrogen signaling pathways. The area under the curve values of 0.8938, 0.9885, and 0.979, obtained from time-dependent receiver-operating-characteristic curve analysis for 1, 3, and 5-year overall survival confirmed the good performance of the model under consideration. S100A8 expression was not detected in the normal prostate tissue but was detected in PRAD.ConclusionsWe identified ISLR as a potential biomarker for PRAD bone metastasis. Moreover, the genes identified to have prognostic value may act as therapeutic targets for PRAD bone metastasis.
Does Dysmenorrhea Affect Clinical Features and Long-Term Surgical Outcomes of Patients With Ovarian Endometriosis? A 12-Year Retrospective Observational Cohort Study
Authors: Wu Yushi , Li Xiaoyan , Dai Yi , Shi Jinghua , Gu Zhiyue , Zhang Jing , Zhang Chenyu , Yan Hailan , Leng Jinhua 
Published: June 2022

BackgroundTo examine and compare the differences in clinical characteristics and long-term postoperative outcomes of ovarian endometriomas (OMA) patients with and without dysmenorrhea, including data from at least 8 years of postoperative follow-up examinations.MethodsRetrospective analysis of 334 OMA patients, including their demographic and clinical data. Long-term follow-up record was also collected. All laparoscopic cystectomy procedures were performed by the same surgeon at Peking Union Medical College Hospital between January 2009 and April 2013. Patients were divided into the dysmenorrhea and non-dysmenorrhea groups to perform the analysis of their preoperative characteristics, relevant surgical findings, and postoperative outcomes at the follow-up.ResultsOut of 334 OMA patients, 257 (76.9%) patients were allocated to the dysmenorrhea group, while the rest 77 (23.1%) patients were included in the non-dysmenorrhea group. Compared with the dysmenorrhea group, the non-dysmenorrhea group exhibited a reduced proportion of chronic pelvic pain (CPP) (P = 0.003), dyspareunia (P &lt; 0.001), tenesmus (P &lt; 0.001), concurrency of deep infiltrating endometriosis (DIE) (P &lt; 0.001), and adenomyosis (P = 0.032). Preoperative infertility was significantly higher in the dysmenorrhea group (P = 0.001). The mean operating time in the dysmenorrhea vs. the non-dysmenorrhea group was 68.0 vs. 56.0 min (P &lt; 0.001). According to the revised American Fertility Society (rAFS) scoring system, the mean scores of the two groups were 52.1 vs. 44.6 (P = 0.033). During follow-up, the dysmenorrhea group showed a higher rate of disease relapse (P &lt; 0.001). A minimum postoperative follow-up period of 8 years was required to evaluate the pregnancy outcomes. Successful pregnancies were identified in 97/257 (37.7%) cases in the dysmenorrhea group and 36/77(46.8%) cases in the non-dysmenorrhea group (P = 0.157), respectively. Though the dysmenorrhea group had a higher rate of postoperative infertility, differences were not significant between the two groups.ConclusionsCompared with the dysmenorrhea group, OMA patients without dysmenorrhea exhibited lower proportions of CPP, dyspareunia, tenesmus, lower concurrency of DIE and adenomyosis, shorter mean operating time, lower mean rAFS scores, and lower infertility rates. During the long-term follow-up, a lower recurrence rate was observed in the non-dysmenorrhea group. Regarding fertility outcomes, non-dysmenorrhea patients had a higher likelihood of successful pregnancy after surgery. Postoperative management needs to be evaluated separately according to dysmenorrhea pathology.