bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusion of fibroblasts and collagen fibrils in the cytologic grading of canine cutaneous mast cell tumors
Authors: Paes Paulo R. O. , Horta Rodrigo S. , Luza Ludimila C. , Pierezan Felipe , Costa Mariana P. , Lavalle Gleidice E. 
Published: April 2022

AbstractBackgroundFibroblasts and/or collagen fibrils have not been included in previous cytologic grading schemes of canine mast cell tumors (MCTs), and their association with biological behavior is broadly debated.ObjectivesThis study aimed to evaluate the cytologic findings of canine MCT, with emphasis on the microenvironment, and propose a novel cytologic grading system correlated with mortality and histologic grade.Material and MethodsCytology smears of canine cutaneous MCTs were retrospectively reviewed and compared with their histopathologic counterparts using Cohen´s Kappa test. One‐year survival rates were also compared with the cytologic and histopathologic variables using Pearson´s correlation test.ResultsFrom 92 first‐occurrence canine cutaneous MCTs, the five features most associated with mortality were selected for a new grading system. The five features were cytoplasmic granulation, fibroblast and/or collagen fibril concentrations, and the presence of mitotic figures, multinucleation, and karyomegaly. Among concordant histopathologic and cytologic cases (ie, the same grades using both systems), mortality rates were 2.6% (1/38) for low‐grade and 71.4% (10/14) for high‐grade cases (P < 0.001, chi‐square). For false‐negative and false‐positive results, mortality rates were 33% (1/3) and 45% (5/11), respectively (P = 0.707).ConclusionsUnlike the Camus cytologic grading system, the present amendment excluded binucleation and included fibroblasts and/ or collagen fibrils, which in higher concentrations were associated with increased survival and a low histopathologic grade. Cytologic grading with the inclusion of fibroblast and collagen fibril concentrations correlated with survival, as did the Camus cytologic and Kiupel histopathologic grades; however, further studies are needed to confirm the prognostic value of this novel cytologic grading scheme.
Seismic anisotropy in the central Tien Shan unveils rheology-controlled deformation during intracontinental orogenesis
Authors: Zhang Bingfeng , Bao Xuewei , Xu Yixian 
Published: April 2022

AbstractThe initiation and evolution of compressional intracontinental orogens are favored by rheologically weak lithosphere underneath; however, how this weakened lithosphere responds to the regional stress regime remains vigorously debated. The Tien Shan mountains in central Asia provide the best example to illustrate the deep deformational responses to intracontinental orogenesis. We present new constraints on the nature of seismic anisotropy in the crust and upper mantle of the central Tien Shan through shear-wave splitting analyses. Our results reveal a sharp change in the orientations of crustal anisotropic fabrics on two sides of the mountains. The convergence-parallel fast orientations in the northern segment are closely related to the lower-crustal simple-shear deformation caused by the underthrusting of the Kazakh Shield, whereas the depth-independent orogen-parallel fast orientations in the southern segment suggest vertically coherent pure-shear thickening of the Tien Shan lithosphere in response to the northward indentation of the Tarim Basin. The thickened lithosphere has partly foundered into the deep mantle, contributing to the accelerated shortening deformation in the late Cenozoic. Our observations demonstrate the complex tectonic processes in the Tien Shan and suggest that the rheological properties of bounding blocks can play a significant role in shaping the lithospheric structures of intracontinental orogens.
Sulfide-associated hydrothermal dolomite and calcite reveal a shallow burial depth for Alpine-type Zn-(Pb) deposits
Authors: Giorno M. , Barale L. , Bertok C. , Frenzel M. , Looser N. , Guillong M. , Bernasconi S.M. , Martire L. 
Published: April 2022

Abstract
Difficulties in dating Mississippi Valley–type (MVT) mineral deposits and the often closely associated dolomitization have led to controversy regarding their origin. We report the first radiometric ages for the Gorno mining district in northern Italy, an example of the Alpine subclass of MVT deposits. U-Pb ages of hydrothermal carbonates pre- and postdating the ore-forming event show that base-metal mineralization occurred shortly after the deposition of the Carnian host rocks. This implies that the Gorno ore deposits formed at shallow burial depth prior to the Early Jurassic western Tethys rifting phase. Contemporaneous Triassic magmatism and extensional tectonics likely contributed to the high geothermal heat fluxes required to drive the mineralizing system. Our study reinforces the need for reliable geochronological data for metallogenic models and warns against a general application of classic North American MVT models to similar deposits worldwide.
Biochemical components ofSphagnumand persistence in peat soil
Authors: Pipes Gwendolyn T. , Yavitt Joseph B. 
Published: April 2022

The amounts and arrangements of polysaccharides (cellulose and hemicellulose), proteins, phenolic lignin, and pectin that make up plant tissue, in part, determine its decay rate. Lignin-rich and/or nitrogen-poor tissue has been described as biochemically recalcitrant causing a slow decay rate. Although a controversial mechanism for organic matter storage in soils with mineral particles, biochemical recalcitrance is still poorly understood in organic peat soil (Histosols). To investigate the role of Sphagnum in formation of peat soil, we characterize biochemical components for 10 species and examine persistence of the components in soil to 150 cm depth in three peatland ecosystems. We hypothesize that species from hummock microforms have more biochemical structural components and cohesion than species from hollows. Relative proportions of biochemical components changed markedly between plant material and the top 10 cm of peat soil, suggesting that decomposition occurred at the peat soil surface, but thereafter relative proportions of biochemical components did not vary significantly to 150 cm deep. A few differences in biochemical components that distinguished hummock species from hollow species persisted to the deepest depth sampled. Although persistence of the lignin-like component was expected, persistence of soluble and ionically bound pectin compounds was surprising as these biopolymers are thought to be readily decomposable. Our findings indicate that structural components of Sphagnum, specifically polysaccharides and pectin in addition to oft-cited phenolic lignin-like components, persist in peat soil and should not be overlooked in trying to understand carbon dynamics in Sphagnum-dominated ecosystems.
Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke
Authors: Li Keliang , Zhang Qiting , Lu Xuesheng , Yao Shengqi 
Published: April 2022

For investigating an influence on butylphthalide sodium chloride injection combined with edaravone dexborneol on neurological function and serum inflammatory factor levels in sufferers having acute ischemic stroke, 120 sufferers having acute ischemic stroke from September 2020 to September 2021 are chosen for the study subjects. In line with the diverse therapies, they took part in a control group and the study group, with 60 examples in each group. The control group is treated with edaravone dexborneol, and the study group is treated with butylphthalide sodium chloride injection, based on the control group. The posttreatment curative efficacy on the two groups is recorded, and treatment of both the two groups is compared. Before and after neurological function indexes (NIHSS and mRS), inflammatory factor indexes (IL-6, CRP, and TNF-α), life quality index (Barthel index), hemorheological indexes (plasma-specific viscosity), and neurological levels of NSE are logged and contrasted between the two groups of adverse reactions during therapy. Postcure, the overall response rate and Barthel index of the study group obviously overtop those of the control group (

p

< 0.05). IL-6, CRP, TNF-α, NSE, plasma specific viscosity, and NIHSS and mRS scores obviously hypodown those of the control group (

p

< 0.05), and untoward effects on the two groups during curing are lower, and the discrepancy is not obvious(

p

> 0.05). Butylphthalide sodium chloride injection combined with edaravone dexborneol can enhance curative efficacy on sufferers having acute ischemic stroke, improve neurological function, blood rheology, and quality of life, and decrease the secretion of cytokine, having a better effect and high medication safety.
EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion–Positive Cholangiocarcinoma
Authors: Wu Qibiao , Zhen Yuanli , Shi Lei , Vu Phuong , Greninger Patricia , Adil Ramzi , Merritt Joshua , Egan Regina , Wu Meng-Ju , Yin Xunqin , Ferrone Cristina R. , Deshpande Vikram , Baiev Islam , Pinto Christopher J. , McLoughlin Daniel E. , Walmsley Charlotte S. , Stone James R. , Gordan John D. , Zhu Andrew X. , Juric Dejan , Goyal Lipika , Benes Cyril H. , Bardeesy Nabeel 
Published: April 2022

Abstract

FGFR inhibitors are approved for the treatment of advanced cholangiocarcinoma harboring FGFR2 fusions. However, the response rate is moderate, and resistance emerges rapidly due to acquired secondary FGFR2 mutations or due to other less-defined mechanisms. Here, we conducted high-throughput combination drug screens, biochemical analysis, and therapeutic studies using patient-derived models of FGFR2 fusion–positive cholangiocarcinoma to gain insight into these clinical profiles and uncover improved treatment strategies. We found that feedback activation of EGFR signaling limits FGFR inhibitor efficacy, restricting cell death induction in sensitive models and causing resistance in insensitive models lacking secondary FGFR2 mutations. Inhibition of wild-type EGFR potentiated responses to FGFR inhibitors in both contexts, durably suppressing MEK/ERK and mTOR signaling, increasing apoptosis, and causing marked tumor regressions in vivo. Our findings reveal EGFR-dependent adaptive signaling as an important mechanism limiting FGFR inhibitor efficacy and driving resistance and support clinical testing of FGFR/EGFR inhibitor therapy for FGFR2 fusion–positive cholangiocarcinoma.

Significance:
We demonstrate that feedback activation of EGFR signaling limits the effectiveness of FGFR inhibitor therapy and drives adaptive resistance in patient-derived models of FGFR2 fusion–positive cholangiocarcinoma. These studies support the potential of combination treatment with FGFR and EGFR inhibitors as an improved treatment for patients with FGFR2-driven cholangiocarcinoma.
This article is highlighted in the In This Issue feature, p. 1171
Reconnaître et intégrer les Antillais catholiques en Île-de-France
Authors: Malogne-Fer Gwendoline 
Published: April 2022

Résumé
Face à l’ ampleur des migrations antillaises vers la métropole à partir des années 1960, l’ Église catholique a mis en place une aumônerie nationale antillo-guyanaise destinée à aider les Antillais catholiques à s’ insérer dans leurs paroisses respectives. Après avoir rappelé le contexte historique de ces migrations antillaises en métropole, cet article analyse la genèse et les limites de ce modèle organisationnel de l’ aumônerie nationale antillo-guyanaise. Dans un troisième temps, à partir de l’ étude de la paroisse de Saint-Denys de l’ Estrée (à Saint-Denis), nous nous interrogerons sur les modalités d’ engagement des Antillais catholiques en montrant comment l’ engagement local se conjugue avec la fréquentation d’ autres hauts lieux du catholicisme parisien. Ces pratiques cumulatives ou circulatoires laissent entrevoir toute une gamme de pratiques populaires parfois qualifiées de « magico-religieuses » par la hiérarchie ecclésiale qui invitent à s’ interroger sur les modalités de catégorisation de l’ Église et sur le rapport que les Antillais catholiques entretiennent à l’ institution ecclésiale.
An Early Islamic Rock Crystal Amulet Seal from Unguja Ukuu, Zanzibar
Authors: Sarathi Akshay , Kenoyer J. Mark , Walz Jonathan R. 
Published: April 2022

Abstract
Archaeological excavations at Unguja Ukuu recovered a rock crystal cabochon seal with the word lillāh (“for God”) inscribed in the Kufic script on its domed surface. The artifact is an intaglio amulet seal engraved in the negative. Microscopic examination of the seal surfaces reveals that a rotary tool was used to make the initial inscription. At some later point, a diagonal spall was removed across part of the inscription. The diagonal spall appears to be along a natural crystal plane. It is impossible to determine if this was the result of intentional defacement or an accidental process that might have resulted in the eventual deposition of the seal. Strata dated by radiometric and relative methods coupled with the style of the Kufic script date the seal to the late-8th to 9th centuries CE. This artifact is the earliest known example of an Islamic amulet seal and of writing in the Zanzibar Archipelago.
Male and Female in Distinction and Glory
Authors: Gilson Rachel 
Published: April 2022

Abstract
Contemporary questions of sex, gender, and transgender identities are not addressed directly by any biblical text, and yet the church needs wisdom on these topics. This article examines the so-called head-coverings passage, 1 Corinthians 11:2–16, with an eye towards principles that could be applied today. While no reading of this text is untroubled, the dynamic tension that the Apostle Paul puts forward between the distinction of male and female, and their equality before the Lord, can shed important light. After exegetical engagement with the text, the article discusses relevant continuities and discontinuities between the original audience and the modern West, leading to recommendations for faithful presence. These include holding to God’s good design of humanity as male and female, while striving to be a community of compassion towards those who identify as transgender or who experience gender dysphoria.
Healthy Eating as a New Way of Life: A Qualitative Study of Successful Long-Term Diet Change
Authors: James Anna , Lawrence Blake , O’Connor Moira 
Published: April 2022

Background Improving diet quality has been shown to be an effective way to improve health and well-being. Yet information on how to assist those wanting to transition to and maintain a healthier diet is still limited. The aim of this study was to explore what motivated people to initiate and maintain a healthy diet. Methods Semi-structured interviews were conducted with 20 participants (all Australian residents) who had made significant improvements to their diets and had maintained these changes for a minimum of two years ( n female = 15, n male = 5, M age = 37.7, SD = 12.4). The transcripts were analysed using thematic analysis which identified five overarching themes: A desire to feel better, investigation and learning, helpful habits, benefits, and values. Results Participants reported a strong wish to feel better and investigated the role of diet as a possible way to improve well-being. Through daily habits and continuous engagement with the topic, healthy eating became a way of life for many participants. Experiencing the benefits of a healthier diet and having developed strong values regarding diet and health supported long-term maintenance. Conclusions Findings from the present study contribute to the literature in highlighting the importance of internal motivation and autonomy for health behaviours. Findings may inform the development of healthy eating interventions. Encouraging autonomy, fostering values aligned with a healthier diet, and helping individuals establish daily habits is likely to support change.
Cognition and Diabetes: Examining Sex Differences Using a Longitudinal Sample of Older Adults
Authors: Palarino Justin V. , Boardman Jason D. , Rogers Richard G. 
Published: April 2022

Objectives: This study aims to investigate sex-based differences in the diabetes status and cognition relationship using a representative sample of older Americans. Methods: Using a sample of 19,190 females and 15,580 males from the Health and Retirement Study, we conduct mixed-effects linear regression analyses to examine sex differences in the association between diabetes and cognition over a 20-year follow-up period among older adults in the United States. Main Findings: Females experience slightly steeper declines in cognition that are further exacerbated by diabetes. At age 65, females without diabetes have significantly higher cognition than males; this gap is eliminated by age 85. Among diabetics, there is no initial sex disparity, but females’ cognition becomes significantly lower than males’ over the following 20 years. Principal Conclusions: Relative to males, females are particularly susceptible to diabetes-related declines in cognition with increasing age.
3D finite element modeling and multi-objective optimization for controlling the electrochemical discharge drilling parameters using the tool feed monitoring system
Authors: Rajput Viveksheel , Goud Mudimallana , Suri Narendra Mohan 
Published: April 2022

Electrochemical discharge machining drilling (ECDD) is acknowledged as a hybrid machining process that employs the thermal erosion and etching action for drilling. Apart from experimental findings, very rare 3D simulation studies have been covered for analyzing the ECDD. In the present investigation, a 3D simulation of the ECDD process is performed to analyze the process based on the finite element method (FEM). The predicted results are found to be in consensus with the experimental results. An increment of 10.79 mg and 5.04 mg in MRR is noticed with the concentration level increase from 10 wt.% to 60 wt.% and voltage level increase from 35V to 55V. However, a maximum error of 12.68% is observed with the FEM method of prediction when compared to experimental results. The simulation study is followed by the multi-objective optimization (Taguchi’s L16) using grey relational analysis (GRA) for controlling the ECDD parameters. The simultaneous numerical and experimental assessment of the process with 3D Gaussian heat distribution using a novel tool feed monitoring system during soda-lime glass machining leads to the article’s novelty. A unique study on a number of tool contacts (NTC) with the work material is performed to minimize it to improve the geometrical characteristics. Material removal rate, overcut, number of tool contacts, and heat-affected zone are picked as response characteristics while tool feed rate, electrolyte concentration, applied voltage, and inter-electrode gap are selected as input variables. GRA optimized variables are obtained as 40V, 10 wt.%, 3 mm/min, and 35 mm with tool feed rate identified as the ascendant input variable having 35.46 percentage contribution.
Mobile phones and the experience of time: New perspectives from a deprivation study of teenagers
Authors: Rosenberg Hananel , Blondheim Menahem , Sabag-Ben Porat Chen 
Published: April 2022

A number of studies have sought to understand how mobile phones affect time practices, and beyond them, the experience of time in users’ daily lives. This article is a further effort in that direction, employing the deprivation study method. We conducted a field study of 80 adolescents, or “cellular natives,” separating them from their cellphones for 1 week. The findings indicate that the cellphone’s absence indeed had a dominant impact on a variety of adolescents’ time-related practices and experience, that yielded in turn both negative and positive feelings. We propose three main axes for understanding the cellphone’s implications for the time experience: The mobile’s flexible time v. Rigid time, its ritual time v. Linear time, and its fragmented time v. Continuous time. In all these dimensions, we point to distinct features of the time experience associated with the mobile phone, and also try to relate it to the emotional state and state of mind of today’s teens. In conclusion, we propose that a broad understanding of the cellphone’s role need to include the aspect of time, at least as it is experienced by adolescents in our current media climate.
Chronic Deciduitis With Plasma Cells: A Quantitative and Clinicopathological Analysis Concerning Different Trimesters
Authors: Feist Henning , Schaumann Nora , Bajwa Simin , Hager Thomas , von Kaisenberg Constantin , Pecks Ulrich 
Published: April 2022

Background: Chronic deciduitis is a chronic inflammatory placental disease. It is associated with severe perinatal complications, especially recurrent miscarriage, preterm birth, preterm labor, and preterm prelabor rupture of membranes. Methods: This study presents a detailed quantification of plasma cells and lymphocytes, and regards clinicopathological associations concerning different trimesters in 99 cases displaying chronic deciduitis with plasma cells (CD), 23 cases from the second trimester and 76 cases from the third trimester, respectively. The control group without CD consisted of matched placentas concerning the gestational weeks. Results: In every instance lymphocytes were more numerous than plasma cells. The mean value/highest score in ten high power fields were 50/321 for plasma cells, and 460/995 for lymphocytes, respectively. In the second trimester the scores for plasma cells were significantly higher than in the third trimester. In the third trimester preterm labor occurred significantly more often in cases with chronic deciduitis related to the control group ( P < .05). Conclusion: In chronic deciduitis the plasma cell count is usually higher in the second compared to the third trimester. A brisk infiltration of the decidua with plasma cells could probably point to a more severe clinical manifestation and a higher risk for preterm labor and preterm birth.