bluuebunny/crossref_metadata_2025_split huggingface dataset:
2‐(N‐3‐Sulfopropyl‐N,N‐dimethyl ammonium)ethyl methacrylate modified graphene oxide embedded into cellulose acetate ultrafiltration membranes for improved performance
Authors: Xabela Sinethemba , Moutloali Richard Motlhaletsi 
Published: March 2022

AbstractN‐(3‐sulfopropyl)‐N‐(methacryloxyethyl)‐N,N‐dimethylammonium betaine (SBMA) modified graphene oxide composite used as a filler in the fabrication of a nanocomposite cellulose acetate membrane was grafted through reverse atom transfer radical polymerization (RATRP) technique from a GO‐Br precursor. All the prepared materials (GO, GO‐Br, PSBMA@GO) were characterized using a combination of FTIR, BET, TEM, TGA, RAMAN, and XRD. The effect of different GO and PSBMA@GO contents on cellulose acetate membranes was investigated using AFM, contact angle measurements and SEM techniques. The surface hydrophilicity of the fabricated membranes increased with increasing content of PSBMA@GO filler through the water contact angle method. The relative flux of the base membrane at 900 kPa was 66.6 L.m−2.h−1 compared to that of PSBMA@GO composite membrane (0.5 wt%) at 117.67 L.m−2.h−1. The addition of the PSBMA@GO composites resulted in increased fouling resistance with high‐flux recovery (93%) and low‐overall flux decrease ratios (0.01%). Furthermore, nanocomposite membranes exhibited higher dye rejections for Congo Red (CR, 99.1% hence confirming their UF nature), methyl orange (MO, 84.2%) and methylene blue (MB, 95.3%) dyes compared with unmodified CA membranes. Overall, these nanocomposite membranes showed promising properties as potential candidates for dye removal in textile wastewater.
The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology Points to Consider for Diagnosis and Management of Autoinflammatory Type I Interferonopathies:CANDLE/PRAAS,SAVI, andAGS
Authors: Cetin Gedik Kader , Lamot Lovro , Romano Micol , Demirkaya Erkan , Piskin David , Torreggiani Sofia , Adang Laura A. , Armangue Thais , Barchus Kathe , Cordova Devon R. , Crow Yanick J. , Dale Russell C. , Durrant Karen L. , Eleftheriou Despina , Fazzi Elisa M. , Gattorno Marco , Gavazzi Francesco , Hanson Eric P. , Lee‐Kirsch Min Ae , Montealegre Sanchez Gina A. , Neven Bénédicte , Orcesi Simona , Ozen Seza , Poli M. Cecilia , Schumacher Elliot , Tonduti Davide , Uss Katsiaryna , Aletaha Daniel , Feldman Brian M. , Vanderver Adeline , Brogan Paul A. , Goldbach‐Mansky Raphaela 
Published: March 2022

ObjectiveAutoinflammatory type I interferonopathies, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature/proteasome‐associated autoinflammatory syndrome (CANDLE/PRAAS), stimulator of interferon genes (STING)–associated vasculopathy with onset in infancy (SAVI), and Aicardi‐Goutières syndrome (AGS) are rare and clinically complex immunodysregulatory diseases. With emerging knowledge of genetic causes and targeted treatments, a Task Force was charged with the development of “points to consider” to improve diagnosis, treatment, and long‐term monitoring of patients with these rare diseases.MethodsMembers of a Task Force consisting of rheumatologists, neurologists, an immunologist, geneticists, patient advocates, and an allied health care professional formulated research questions for a systematic literature review. Then, based on literature, Delphi questionnaires, and consensus methodology, “points to consider” to guide patient management were developed.ResultsThe Task Force devised consensus and evidence‐based guidance of 4 overarching principles and 17 points to consider regarding the diagnosis, treatment, and long‐term monitoring of patients with the autoinflammatory interferonopathies, CANDLE/PRAAS, SAVI, and AGS.ConclusionThese points to consider represent state‐of‐the‐art knowledge to guide diagnostic evaluation, treatment, and management of patients with CANDLE/PRAAS, SAVI, and AGS and aim to standardize and improve care, quality of life, and disease outcomes.
Vertebral Bone Mineral Density, Vertebral Strength, and Syndesmophyte Growth in Ankylosing Spondylitis: The Importance of Bridging
Authors: Tan Sovira , Bagheri Hadi , Lee David , Shafiei Ahmad , Keaveny Tony M. , Yao Lawrence , Ward Michael M. 
Published: March 2022

ObjectiveTo examine the relationship between vertebral trabecular bone mineral density (tBMD), vertebral strength, and syndesmophytes in patients with ankylosing spondylitis (AS) using quantitative computed tomography (QCT).MethodsWe performed QCT of the spine to measure syndesmophytes and tBMD in 5 vertebrae (T11–L3) in 61 patients with AS. Finite element analysis was performed to measure vertebral strength in compressive overload, including in trabecular and cortical compartments. In cross‐sectional analyses, we examined associations of syndesmophyte height with tBMD and vertebral strength in each vertebra. In 33 patients followed up for 2 years, we investigated whether baseline tBMD and vertebral strength predicted syndesmophyte growth in the same vertebra, and vice versa.ResultsIn the cross‐sectional analyses, 126 vertebrae had bridging, 77 vertebrae had nonbridging syndesmophytes, and 83 vertebrae had no syndesmophytes. There were strong inverse associations between syndesmophyte height and tBMD, total strength, and trabecular strength only among bridged vertebrae. In the longitudinal analysis, nonbridged vertebrae with low tBMD (adjusted β = –0.01 [95% confidence interval (95% CI) –0.019, –0.0012]) and low strength (adjusted β = –0.0003 [95% CI –0.0004, –0.0002]) had more syndesmophyte growth over time. Similar associations were absent among bridged vertebrae. Conversely, vertebrae with bridging at baseline had a significant loss in percent tBMD over time (adjusted β = –0.001 [95% CI –0.0017, –0.0004]).ConclusionAssociations between syndesmophytes and vertebral density and strength in AS differ between bridged and nonbridged vertebrae. Among nonbridged vertebrae, low tBMD and strength are associated with syndesmophyte growth. Bridging is associated with large subsequent losses in tBMD, possibly due to mechanical offloading.
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
Authors: Lundtoft Christian , Pucholt Pascal , Martin Myriam , Bianchi Matteo , Lundström Emeli , Eloranta Maija‐Leena , Sandling Johanna K. , Sjöwall Christopher , Jönsen Andreas , Gunnarsson Iva , Rantapää‐Dahlqvist Solbritt , Bengtsson Anders A. , Leonard Dag , Baecklund Eva , Jonsson Roland , Hammenfors Daniel , Forsblad‐d'Elia Helena , Eriksson Per , Mandl Thomas , Magnusson Bucher Sara , Norheim Katrine B. , Auglænd Johnsen Svein Joar , Omdal Roald , Kvarnström Marika , Wahren‐Herlenius Marie , Notarnicola Antonella , Andersson Helena , Molberg Øyvind , Diederichsen Louise Pyndt , Almlöf Jonas , Syvänen Ann‐Christine , Kozyrev Sergey V. , Lindblad‐Toh Kerstin ,   the DISSECT Consortium,   the ImmunoArray Development Consortium, Nilsson Bo , Blom Anna M. , Lundberg Ingrid E. , Nordmark Gunnel , Diaz‐Gallo Lina Marcela , Svenungsson Elisabet , Rönnblom Lars 
Published: March 2022

ObjectiveCopy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation is connected to the autoimmune repertoire in systemic lupus erythematosus (SLE), primary Sjögren's syndrome (SS), or myositis.MethodsUsing targeted DNA sequencing, we determined the copy number and genetic variants of C4 in 2,290 well‐characterized Scandinavian patients with SLE, primary SS, or myositis and 1,251 healthy controls.ResultsA prominent relationship was observed between C4A copy number and the presence of SSA/SSB autoantibodies, which was shared between the 3 diseases. The strongest association was detected in patients with autoantibodies against both SSA and SSB and 0 C4A copies when compared to healthy controls (odds ratio [OR] 18.0 [95% confidence interval (95% CI) 10.2–33.3]), whereas a weaker association was seen in patients without SSA/SSB autoantibodies (OR 3.1 [95% CI 1.7–5.5]). The copy number of C4 correlated positively with C4 plasma levels. Further, a common loss‐of‐function variant in C4A leading to reduced plasma C4 was more prevalent in SLE patients with a low copy number of C4A. Functionally, we showed that absence of C4A reduced the individuals’ capacity to deposit C4b on immune complexes.ConclusionWe show that a low C4A copy number is more strongly associated with the autoantibody repertoire than with the clinically defined disease entities. These findings may have implications for understanding the etiopathogenetic mechanisms of systemic inflammatory autoimmune diseases and for patient stratification when taking the genetic profile into account.
Spannbetonkastenquerschnitte mit Stegspanngliedern und verbundloser Quervorspannung
Authors: Krill Alfred , Zehetmaier Gerhard 
Published: March 2022

AbstractMit Einführung der Regelungen und Richtlinien für die Bemessung von Ingenieurbauten (BEM‐Ing) speziell zur Berechnung und Bemessung von Betonbrücken (Teil 1, Abschnitt 2) wird sich der Straßenbrückenbau in Spannbetonbauweise verändern. Erstmals seit dem Jahr 1999 ist dann wieder die Anordnung interner Spannglieder in den Stegen von Kastenträgern zugelassen. Um jedoch die bei manchen Straßenbrücken beobachteten Unzulänglichkeiten zu vermeiden, die u. a. aus einer mangelhaften Verdichtung des Stegbetons herrühren, sind zukünftig schärfere Randbedingungen zum Einsatz der Stegspannglieder im Straßenbrückenbau verankert, während deren Einsatzmöglichkeiten im Bahnbrückenbau unverändert bleiben. Zudem wird ausdrücklich empfohlen, Fahrbahnplatten großer Breite mit Quervorspannung auszubilden. Zur Durchbiegungsbegrenzung quervorgespannter Fahrbahnplatten ist in der BEM‐Ing die maximale Quervorspannkraft begrenzt, über die sich mit dem Dekompressionsnachweis die erforderliche Plattendicke ermitteln lässt. Der vorliegende Aufsatz gibt Hinweise zu Entwurf und Konstruktion von Spannbetonkastenbrücken nach neuer BEM‐Ing und zeigt auf, welche Bauteildimensionen sich mit den neuen Regeln ergeben.
Bundled or unbundled? A multi‐text corpus‐assisted discourse analysis of the relationship between teaching and research in UK universities
Authors: Matthews Adam , Kotzee Ben 
Published: March 2022

AbstractCreating and disseminating knowledge through research and teaching has long been regarded as the hallmark of the modern university. However, new university business models have called into question the ‘bundling’ of teaching and research, and sustained research on the relationship between teaching and research has found little evidence of an insoluble connection between the two activities. In this article, we explore the relationship between teaching and research from the perspective of universities’ institutional discourse. We use corpus‐assisted discourse analysis to examine the relationship between research and teaching as presented in two sets of institutional texts currently influential in UK Higher Education: Research Excellence Framework environment statements and Teaching Excellence Framework provider submissions (a total of 2143 documents and 12,492,071 words). Our findings show that, while universities emphasise the value of research to their teaching, they do not always emphasise (or sometimes even decry) the influence of teaching on their research. We empirically evidence that, according to what universities themselves write in institutional texts, teaching and research are not always in a mutually beneficial entanglement, but often rather a one‐way relationship in which research expertise and institutional prestige are used to bolster claims of teaching excellence. This has implications for the communication of both the vision and the purpose of a university in regulatory exercises and wider policy, but also speaks to the broader idea and practice of being a university in the twenty‐first century.
The sensorium and fleshy schools
Authors: Page Damien , Sidebottom Kay 
Published: March 2022

AbstractAs places of learning, schools inevitably foreground cognition. Neglected in schools and in the literature is the body, often an inconvenience or barrier to learning rather than a site of perception and understanding. Where the body is considered, it is primarily concerned with pedagogy and children rather than analysing the broad range of embodied experience: teachers' sensuous experience is side‐lined; classrooms are central, with toilets and staffrooms and corridors usually ignored; policy and architecture largely unconsidered. Furthermore, ironically, the focus in the literature also foregrounds the body within its contribution to cognition rather than centring the fleshy experience of sensing. This paper therefore addresses these omissions and focuses on the sensorium—movement, the haptic, hearing, smell/taste and visual—providing a framework to analyse the truly embodied experience of the school environment. It argues that as well as being culturally bound, the sensorium is delineated and encoded within the educational ideology and architecture of schools, prescribed by senior leaders to manage and police the flesh within their school walls.
Neuron‐glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila
Authors: Boulanger Ana , Dura Jean‐Maurice 
Published: March 2022

AbstractNeuronal remodeling is a conserved mechanism that eliminates unwanted neurites and can include the loss of cell bodies. In these processes, a key role for glial cells in events from synaptic pruning to neuron elimination has been clearly identified in the last decades. Signals sent from dying neurons or neurites to be removed are received by appropriate glial cells. After receiving these signals, glial cells infiltrate degenerating sites and then, engulf and clear neuronal debris through phagocytic mechanisms. There are few identified or proposed signals and receptors involved in neuron‐glia crosstalk, which induces the transformation of glial cells to phagocytes during neuronal remodeling in Drosophila. Many of these signaling pathways are conserved in mammals. Here, we particularly emphasize the role of Orion, a recently identified neuronal CX3C chemokine‐like secreted protein, which induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling. Although, chemokine signaling was not described previously in insects we propose that chemokine‐like involvement in neuron/glial cell interaction is an evolutionarily ancient mechanism.
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance
Authors: Philipp Thilo Magnus , Gong Weiye , Köhnlein Karl , Ohse Verena Alexia , Müller Frederike Iris , Priebs Josephine , Steinbrenner Holger , Klotz Lars‐Oliver 
Published: March 2022

AbstractMethanethiol is a toxic gas produced through bacterial degradation of sulfur‐containing amino acids. Applying a novel enzymatic assay, we here identified a methanethiol oxidase (MTO) that catalyzes the degradation of methanethiol in the nematode Caenorhabditis elegans (C. elegans). The corresponding protein, Y37A1B.5, previously characterized as a C. elegans ortholog of human selenium‐binding protein 1 (SELENBP1), was renamed SEMO‐1 (SELENBP1 ortholog with methanethiol oxidase activity). Worms rendered deficient in SEMO‐1 not only showed decreased hydrogen sulfide production from methanethiol catabolism but they were also more resistant to oxidative stress and had an elevated life span. In contrast, resistance to selenite was significantly lowered in SEMO‐1‐deficient worms. Naturally occurring mutations of human SELENBP1 were introduced to recombinant SEMO‐1 through site‐directed mutagenesis and resulted in loss of its MTO activity, indicating a similar enzymatic mechanism for SELENBP1 and SEMO‐1. In summary, SEMO‐1 confers resistance to toxic selenite and the ability to metabolize toxic methanethiol. These beneficial effects might be a trade‐off for its negative impact on C. elegans life span.
Rapid production of SaCas9 in plant‐based cell‐free lysate for activity testing
Authors: Schiermeyer Andreas , Cerda‐Bennasser Pedro , Schmelter Thomas , Huang Xin , Christou Paul , Schillberg Stefan 
Published: March 2022

AbstractCas9 nucleases have become the most versatile tool for genome editing projects in a broad range of organisms. The recombinant production of Cas9 nuclease is desirable for in vitro activity assays or the preparation of ribonucleoproteins (RNPs) for DNA‐free genome editing approaches. For the rapid production of Cas9, we explored the use of a recently established cell‐free lysate from tobacco (Nicotiana tabacum L.) BY‐2 cells. Using this system, the 130‐kDa Cas9 nuclease from Staphylococcus aureus (SaCas9) was produced and subsequently purified via affinity chromatography. The purified apoenzyme was supplemented with 10 different sgRNAs, and the nuclease activity was confirmed by the linearization of plasmid DNA containing cloned DNA target sequences.
Reviewing the applications of artificial intelligence in sustainable supply chains: Exploring research propositions for future directions
Authors: Naz Farheen , Agrawal Rohit , Kumar Anil , Gunasekaran Angappa , Majumdar Abhijit , Luthra Sunil 
Published: March 2022

AbstractThe sustainable supply chain (SSC) has received significant attention worldwide in the last few years because it integrates sustainability dimensions into its process. Recent artificial intelligence (AI)‐based advancements in technology make it possible to overcome many problems associated with supply chain (SC) networks. The current study was performed to explore the role of AI in establishing an SSC. The research contribution in the field of AI and SSC was examined through a systematic literature review. A total of 353 articles were gathered from the Scopus database in the selected research field. A big data‐based approach, namely, structural topic modelling (STM), was applied to generate emerging thematic topics from shortlisted articles of AI in SSC. Moreover, using R package, a bibliometric analysis was conducted to examine the research trends in the field of AI in SSC. The research trends were then analysed, with generated thematic topics discussed. The proposed research framework can help researchers and practitioners to develop an SSC model using AI‐based techniques. Propositions for future research are given and implications are suggested.
Dynamic capabilities for circular manufacturing supply chains—Exploring the role of Industry 4.0 and resilience
Authors: Chari Arpita , Niedenzu Denis , Despeisse Mélanie , Machado Carla Gonçalves , Azevedo João Domingues , Boavida‐Dias Rui , Johansson Björn 
Published: March 2022

AbstractAn organisation's sustainability performance is influenced by its capabilities (skills, resources and competences) which in turn affects the performance of its entire supply chain. However, recent research has not sufficiently explored the convergence of dynamic capabilities, circular economy, resilience and Industry 4.0 concepts for manufacturing supply chains. Therefore, this study aims to identify how dynamic capabilities theory can enable circular and resilient supply chains. A qualitative research process was deployed in three stages: literature review, European project and nine expert interviews. Key investigative variables were used to identify capabilities used in manufacturing, and five research propositions were developed to address the gaps found in literature. The empirical data helped reveal challenges to circular economy implementation and validate the literature findings. The main contributions include a dynamic capabilities model, a causal relationship model and five research propositions for circular economy implementation.
Environmentally sustainable development initiatives in upstream strategic outsourcing relationships: Examining the role of innovative capabilities
Authors: Kulangara Nisha Paul , Biehl Markus , Prater Edmund L. 
Published: March 2022

AbstractResearch on the potential impact of environmental sustainable development initiatives such as environmental collaboration with the supplier (ECS) on environmental and manufacturing performance is inconclusive. Specifically, it has overlooked the intermediary role that dynamic capabilities play in the relationship between ECS and performance. This explains why previous research, while correct in theory, found conflicting statistical results between environmental collaboration upstream and various performance outcomes. This study examines the following questions: What is the impact of environmental collaboration on manufacturing and environmental performance in outsourcing relationships? Do capabilities mediate the relationship between environmental collaboration and performance? Further, we propose that one particular mediating factor—innovative capabilities (ICs)—can influence the strength of this relationship and thus explain why previous research found conflicting statistical results. This paper uses structural equation modeling to analyze survey data from 247 North American manufacturers that outsourced their manufacturing. IC fully mediates the relationship between ECS and manufacturing performance and partially mediates the relationship between environmental collaboration and environmental performance. These findings enrich existing knowledge as it views ECS through the lens of resource‐based theory. Further, we shed light on the crucial role of IC in firms that choose to outsource critical capabilities. From a managerial perspective, the empirical results will inform outsourcing managers making strategic and tactical decisions to achieve desired environmental and manufacturing outcomes.
The anatomy of the cystic duct and its association with cholelithiasis: MR cholangiopancreatographic study
Authors: Garg Shallu , Dutta Usha , Chaluvashetty Sreedhara B. , Kumar Kimavat Hemanth , Kalra Naveen , Sahni Daisy , Aggarwal Anjali 
Published: March 2022

AbstractThe aims of this article are to detail the anatomy of the cystic duct in patients with and without gallstones as it relates to maneuvering of the duct during endoscopic transpapillary gallbladder cannulation, and to elucidate its role in the dynamics of bile flow during gallbladder contraction. One hundred MRCPs were retrieved from the prospectively maintained radiology data system to assess the configuration of the cystic duct and its confluence vis‐a‐vis the main biliary duct. The configuration of the cystic duct was broadly classified into four types: Angular (44%), Linear (40%), Spiral (11%), and Complex (5%). The level of emergence of the cystic duct from the bile duct was proximal in 29%, middle in 49% and distal in 20%. Its direction from the bile duct was to the right and angled upward in 69%, right and angled downward in 15%, left and angled upward in 13%, and left and angled downward in 1%. Its orifice was on the lateral surface of the bile duct in 50%, posterior in 19%, anterior in 15% and medial in 14%. In two cases, the cystic duct opened directly into the duodenum. Tortuous cystic ducts and non‐lateral unions with the bile duct were significantly more prevalent in gallstone cases than the non‐gallstone group (p = 0.02). The present study details the spatial anatomy of the cystic duct vis a vis the main biliary duct. This has not been well investigated to date but has become increasingly relevant with the advent of recent gallbladder interventions.