bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients
Authors: Brands Xanthe , Uhel Fabrice , van Vught Lonneke A. , Wiewel Maryse A. , Hoogendijk Arie J. , Lutter René , Schultz Marcus J. , Scicluna Brendon P. , van der Poll Tom 
Published: July 2022

Objective
Patients admitted to the Intensive Care Unit (ICU) oftentimes show immunological signs of immune suppression. Consequently, immune stimulatory agents have been proposed as an adjunctive therapy approach in the ICU. The objective of this study was to determine the relationship between the degree of immune suppression and systemic inflammation in patients shortly after admission to the ICU.
Design: An observational study in two ICUs in the Netherlands.

Methods
The capacity of blood leukocytes to produce cytokines upon stimulation with lipopolysaccharide (LPS) was measured in 77 patients on the first morning after ICU admission. Patients were divided in four groups based on quartiles of LPS stimulated tumor necrosis factor (TNF)-α release, reflecting increasing extents of immune suppression. 15 host response biomarkers indicative of aberrations in inflammatory pathways implicated in sepsis pathogenesis were measured in plasma.

Results
A diminished capacity of blood leukocytes to produce TNF-α upon stimulation with LPS was accompanied by a correspondingly reduced ability to release of IL-1β and IL-6. Concurrently measured plasma concentrations of host response biomarkers demonstrated that the degree of reduction in TNF-α release by blood leukocytes was associated with increasing systemic inflammation, stronger endothelial cell activation, loss of endothelial barrier integrity and enhanced procoagulant responses.

Conclusions
In patients admitted to the ICU the strongest immune suppression occurs in those who simultaneously display signs of stronger systemic inflammation. These findings may have relevance for the selection of patients eligible for administration of immune enhancing agents.

Trial registration
ClinicalTrials.gov identifier NCT01905033.
Protective effe

cts and potential mechanism of

To

ngxinluo on

mouse with

thromboangiitis obliterans

induced by sodium laurate
Authors: Gu Jiaojiao , Gao Huailin 
Published: July 2022

Background: In China, Tongxinluo (TXL) has been widely used for the treatment of cardio-cerebrovascular diseases. Studies have shown that TXL has anti-inflammatory and antithrombotic properties.
Purpose: This study aimed to investigate the inhibitory effects of TXLon sodium laurate-induced thromboangiitis obliterans(TAO) andthe underlying mechanisms.
Methods: A TAO mousemodel was established by injectingsodium laurate into the femoral artery. After treatment with compound danshen tablet(CDT, 0.52g/kg) and various doses of TXL (0.38, 0.75, 1.5g/kg),the recovery of blood flow in the lower limbs of mice was detected by laser Dopplerimaging. Pathological changes and thrombosis ofthe femoral arterywere observed by hematoxylin and eosin (H&E) staining. Levels of thromboxane B2(TXB
2), 6-keto-prostaglandin F
1α(6-keto-PGF
1α), endothelin-1 (ET-1),IL(interleukin) -1β and IL-6 were measured using enzyme-linked immunosorbent assay (ELISA). Levels of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) were detected by a fully automated biochemical analyzer. The expression of tumor necrosis factor (TNF-α) and inducible nitric oxide synthase (iNOS) in the femoral artery wall was determined by immunohistochemical analysis.
Results: TXL promoted the restoration of blood flow in the lower limbs, reduced the area of thrombosis in the femoral artery, and alleviated the pathological changes in the femoral artery wall. TXL also decreased the expression of TXB
2and ET-1 and increased 6-keto-PGF
1α. TXL reduced the levels of IL-6 and IL-1βand significantly inhibited the overexpression of TNF-αand iNOS in the femoral artery wall. Moreover, TXL prolonged APTT, PT, TT, and reduced FIB levels.
Conclusion: TXLhas a protective effect on TAO mice, and themechanism may involvein theinhibition of thrombosis and TAO-related inflammatory responses.Therefore, TXLmay be a potential drug for the treatment of TAO in conventional medicine.
Optimal loading method of multi type railway flatcars based on improved genetic algorithm
Authors: Yang Zhongliang 
Published: July 2022

Abstract
On the basis of analyzing the complexity of railway flatcar loading optimization problem, according to the characteristics of railway flatcar loading, based on the situation of railway transport loading unit of multiple railway flatcars, this study puts forward the optimal loading optimization method of multimodel railway flatcars based on improved genetic algorithm, constructs the linear programming model of railway flatcar loading optimization problem, and combines with the improved genetic algorithm to solve the problem. The study also analyzes the structural characteristics of the optimal loading materials of multimodel railway flatcars, selects the optimal materials and inputs the relevant data into the computer, and uses MATLAB to program the optimal loading algorithm of multimodel railway flatcars. Through the analysis of the calculation example, the study discusses its scope of application. The experimental results show that the average general utilization rate of the proposed method is 73%, which has higher universality, more effective application, and fully meets the research requirements. It is verified that the proposed method has a statistically significant impact on the optimal loading of multi-type railway flatcars.
On k-regular edge connectivity of chemical graphs
Authors: Ediz Süleyman , Çiftçi İdris 
Published: July 2022

Abstract
Quantitative structure property research works, which are the essential part in chemical information and modelling, give basic underlying topological properties for chemical substances. This information enables conducting more feasible studies between theory and practice. Connectivity concept in chemical graph theory gives information about underlying topology of chemical structures, fault tolerance of molecules, and vulnerability of chemical networks. In this study we first defined two novel types of conditional connectivity measures based on regularity notion: k-regular edge connectivity and almost k-regular edge connectivity in chemical graph theory literature. We computed these new graph invariants for cycles, complete graphs, and Cartesian product of cycles. Our results will be applied to calculate k-regular edge connectivity of some nanotubes which are stated as Cartesian product of cycles. These calculations give information about fault tolerance capacity and vulnerability of these chemical structures.
Validity and Reliability of the Seated Medicine Ball Throw as a Measure of Upper Body Power in Older Women
Authors: Strand Keri L. , Ly Anna S. , Barry Sarah S. , Liscano Jose A. , Trebotich Thomas L. , Martin-Diala Chimaobim , Martin Erick , Signorile Joseph F. 
Published: July 2022

Abstract
Strand, KL, Ly, AS, Barry, SS, Liscano, JA, Trebotich, TL, Martin-Diala, C, Martin, E, and Signorile, JF. Validity and reliability of the seated medicine ball throw as a measure of upper body power in older women. J Strength Cond Res 37(4): 902–908, 2023—In women, aging is associated with diminishing upper body power, which may increase the risk of falls and fall-related injury; however, the validity and reliability of clinical tests to evaluate upper body power need to be confirmed. The seated medicine ball throw (SMBT) is an upper body performance test used to monitor muscle function among older individuals. The purpose of this study was to evaluate the validity and test-retest reliability of the SMBT in older women. Thirty-five women (age = 75.15 ± 6.39 years) participated in this study. Subjects performed SMBT trials using common ball masses (SMBT4lb and SMBT3kg) over 3 sessions. Familiarization with the SMBT and chest press 1 repetition maximum (CP1RM) was provided on the first day. On day 2, subjects repeated the tests, but data were recorded. On day 3, SMBT was retested followed by an evaluation of chest press peak power (CPPP) values at 30–80% of CP1RM. Significant correlations (p ≤ 0.05) were found between the CPPP and SMBT4lb (r = 0.775, p < 0.001) and SMBT3kg (r = 0.734, p < 0.001), and SMBT distance showed expected declines with age (r = −0.724 to −0.626, p < 0.001), demonstrating its validity. High reliability between testing days was found, and Bland-Altman plots showed few points that fell outside the limits of agreement. In conclusion, the SMBT is a valid and highly reliable tool that can be used by health professionals to monitor deficits in upper body muscular power to improve treatment protocols in older women.
Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion): A Narrative Review
Authors: Ipponi Edoardo , Ferrari Elisa , Ruinato Alfio Damiano , De Franco Silvia , Capanna Rodolfo , Andreani Lorenzo 
Published: July 2022

Background: Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora lesion, is a rare proliferative disease arising from the parosteal region of bones. Although BPOP’s pathogenesis is still not certain, modern literature suggests it to be a tumor-like lesion or even a benign neoplasm. Due to the extremely low incidence, to this date studies on the topic are limited to case reports and a few case series. This narrative review aims to resume literature on BPOP and provide an overview of its natural history, morphologic characteristics and prognostic horizon.Materials and methods: A systematic research of the literature was done to identify studies reporting on patients who suffered from BPOP between 1983 and 2021. We collected data regarding aetiologic and pathogenetic theories, patients’ personal data and anamnesis, lesions’ location, clinical presentation, imaging features, pathological appearance, treatment and prognosis.Results: We identified 322 cases of BPOP with a mean age of 34.3 years at the moment of diagnosis. There was no gender difference. The most involved site was the hand, followed by the foot. A history of trauma was reported for 14.7% of the cases. 38.7% of the patients had pain. Literature defined typical radiographic and microscopic patterns that characterize Nora lesions. While imaging is fundamental to orientate towards BPOP, histological evaluation is mandatory to get the definitive diagnosis. To this date, only reliable therapeutic option is represented by surgical resection. BPOP is burdened by a risk of recurrence that accounts to 37.4%.Conclusion: BPOP is a rare benign disease that should be considered during the differential diagnosis of parosteal lesions, especially in the acral regions. Careful diagnostic evaluations are necessary to get the correct diagnosis and wide margins of resection are recommended to minimize the relatively high risk of local recurrence.
Comparative exploration on bifurcation behavior for integer-order and fractional-order delayed BAM neural networks
Authors: Xu Changjin , Mu Dan , Liu Zixin , Pang Yicheng , Liao Maoxin , Li Peiluan , Yao Lingyun , Qin Qiwen 
Published: July 2022

In the present study, we deal with the stability and the onset of Hopf bifurcation of two type delayed BAM neural networks (integer-order case and fractional-order case). By virtue of the characteristic equation of the integer-order delayed BAM neural networks and regarding time delay as critical parameter, a novel delay-independent condition ensuring the stability and the onset of Hopf bifurcation for the involved integer-order delayed BAM neural networks is built. Taking advantage of Laplace transform, stability theory and Hopf bifurcation knowledge of fractional-order differential equations, a novel delay-independent criterion to maintain the stability and the appearance of Hopf bifurcation for the addressed fractional-order BAM neural networks is established. The investigation indicates the important role of time delay in controlling the stability and Hopf bifurcation of the both type delayed BAM neural networks. By adjusting the value of time delay, we can effectively amplify the stability region and postpone the time of onset of Hopf bifurcation for the fractional-order BAM neural networks. Matlab simulation results are clearly presented to sustain the correctness of analytical results. The derived fruits of this study provide an important theoretical basis in regulating networks.
Analyze of early childhood education in the context of inclusive education
Authors: Prudnikova Ilga , Jankovska Jekaterina 
Published: July 2022

Early childhood education means a sequence of levels of education, where the foundation is the concept of "early childhood.” Early childhood is a foundation for social skills knowledge and advances on the following level of education. The imposition of necessary support measures in the education and care of pre-school process provides successive children with special needs inclusion in next level of education. Qualitative early childhood education and care system development principle is that of making early childhood education available for appropriate needs of children and family. The article main tasks is analyze about statistic of early childhood available, analysis of the theories of early development and early child with special needs inclusion education.
Clinico-epidemiological characteristics of pediatric COVID-19 patients in Bangladesh
Authors: Sarkar Probir Kumar , Ghosh Kinkar , Akand Nabila , Kamruzzaman M. , Afroz Shireen , Rahman Maksudur , Roy Puspanjali , Sheefa Maleeha , Rahman Sheikh Wasik , Sayeed Al Reza M. 
Published: July 2022

Background: The objective of the study was to delineate the clinico-epidemiological characteristics of pediatric coronavirus disease-2019 (COVID-19) patients.Methods: This observational study included 290 pediatric patients with a definite diagnosis of COVID-19 admitted to Dhaka Shishu hospital, Bangladesh, from April 2021 to October 2021. Clinical and epidemiological characteristics were analyzed based on demographic data, medical history, laboratory tests, and outcome information. Data analysis was performed with SPSS 26. Ethical measures were taken in compliance with the current declaration of Helsinki, and final analysis was performed using SPSS 26.Results: Of all, 42 (14.5%) were neonates (<28 days), 88 (30.3%) were infants (28 days to <1 year) and 160 (55.2%) were children (1-17 years). The median age of the children was 18 (0.3-204) months, 58.3% were male, 62% had malnutrition, and presented with various clinical presentations. The main symptoms were fever (5.7%) and breathlessness (20%). Approximately 22% of children were asymptomatic, and 57% had at least one comorbidity. Fever and abdominal pain were predominant presenting symptoms in children compared with neonates and infants (p<0.01 for both), while cough and breathlessness were more frequent in infants (p<0.01 for both). The infants suffered significantly from neutropenia and lymphocytosis than neonates and children (p<0.001 for both). The discharge and death rates were 77.8% with 6.9%. Overall case fatality was higher among neonates than others.Conclusions: Compared to other pediatric groups, neonatal case fatality was higher, and COVID-19 in neonates, infants, and children has similar epidemiological and clinical manifestations. The findings from this study might help to guide the development of measures to prevent and treat this ongoing global pandemic of these particular age groups.
Unexplained hepatosplenomegaly: a storage disorder
Authors: Rao Jayashree S. , Sreekantham Sravyasree , Pradeep Meghashree Vinod , N. Pradeep 
Published: July 2022

Gaucher’s disease (GD), a lysosomal storage disorder is caused by defect in the housekeeping gene lysosomal glucocerebrosidase which is present on the first chromosome (1q22). It was first described by a French physician, Philippe Gaucher in 1882. The metabolic defect is the deficiency of the lysosomal hydrolase β-glucosidase, identified by Brady et al. Hereby we reported a 3 year 6-month-old male child presenting with mass per abdomen. Peripheral smear showed bicytopenia and bone marrow aspiration revealed normal erythropoiesis and Gaucher’s cells in a background of normal erythroid, myeloid, and megakaryocytic lineage cells. An impression of lysosomal storage disorder was given and child was evaluated further by genetic analysis. Therefore, we emphasized the importance of early recognition by clinical manifestation and histological findings. The practicing paediatrician should have an index of suspicion for storage disorders as a differential diagnosis of children with unexplained hepatosplenomegaly. Early diagnosis of GD would lead to initiation of effective treatment with enzyme replacement which can decrease morbidity.
Evaluation of the microleakage in class II cavities restored with composite resin by using different placement techniques and light cure units– An in vitro study
Authors: Miskin Swathi , Manduru Chandrasekhar , Sampathi Nagalakshmi Reddy , Nagireddy Upendranatha Reddy , Reddy E Sujayeendranatha , Chandra Sushma 
Published: July 2022

The aim of the present study is to evaluatepost thermocycling microleakage scores in class II cavities restored with Tetetric n ceram (TC) by, Bulk fill technique, Incremental technique, Centripetal techniques, followed by polymerization light source QTH and LED.ethodsClass II Conventional Mesioocclusal (MO) cavities were prepared with occlusal gingival depth 1mm above the CEJ. The final preparation has the following dimensions, 3 mm – buccolingual extension1.5 mm –axial dept hand 4 mm –occluso-cervical extension. The samples will be etched and rinsed, and then the universal matrix will be placed after that the bonding agent will be applied and curedLater all specimens were randomly divided into three groups, each containing 20 teeth.GROUP I-Bulk Technique, GROUPII- Incremental Technique with oblique laying GROUP III-Specimens were stored in distilled water at 37C till it is subjected to thermocycling. Sthermo cycled for 500 cycles at with temperature range of 5 to 55 degrees with 20 seconds dwell time. Specimens were sectioned along the long axis in the mesiodistal direction of the restoration with a diamond disc and analyzed using a stereo microscope at 10x magnification by an independent examiner who was blinded by the groups.Comparison of three groups with microleakage scores at gingival margins by Kruskal Wallis one-way ANOVA test. Pair-wise comparison of all groups with respect to microleakage scores at gingival margins by Mann-Whitney U test. Statistical analysis was performed using SPSS STATISTICS 21.0 software.Among the three experimental groups least microleakage was seen with subgroup IIA (IN-QTH) followed by subgroup IIIA (CE-QTH) followed by subgroup IA (B-QTH).Among all these groups and subgroups, the least microleakage is seen in IN-LED (subgroup IIB), highest microleakage is seen in B-QTH (subgroup IA), interestingly there is no statistical difference between IN-QTH (subgroup IIA) and CE-LED (sub group IIIB).
Study on Prevention and Intervention Policy of Primary School Children with Depression in China
Authors: Yang Haokun 
Published: July 2022

In recent years, the mental health problems of primary school children in China have become prominent, which are
widely concerned by the government, academic circle, and many other sectors of society. This paper analyzes the psychological
problems and causes of primary school children and points out some main psychological problems faced by primary school
children, such as prominent depressive mood, serious anxiety. Based on this, it is proposed that the current situation of primary
school children with depression in China is not optimistic. Through comparing the policy construction of mental health education
in China and the United States as well as other developed countries, this paper compares and analyzes the differences existing
in mental health education policies in primary schools between China, Europe, and the United States. Besides, it probes into the
inspiration to mental health policy system in China and puts forward the reflection and countermeasures for the prevention and
intervention policies of primary school children with depression in China, thus improving the professional methods for prevention
and intervention of primary school children’s depression. At the same time, broadening the channels of prevention and intervention
support for primary school children with depression, and establish an ecological system for this symptom, to provide a reference
for the prevention and intervention policy of primary school children’s depression in China.
Together for a Shared Future, and a Shared Future for Together (Space)!
Authors: Qiu Hanyu , Wu Feifan , Guo Liang 
Published: July 2022

“The very sun irradiates their gorgeous palace, but never bypasses our tatty hut: sunshine is equal.” -Shakespeare
Equity is the common desire of all people in this world, and it is also a silently tacit agreement between countries and the strategic
balance they want to pursue. However, the recent asteroid mining craze seems to be quietly influencing the existing equity degree
around the globe. We developed the World Resource Equity Assessment Model (WREAM) and other related models in order to
measure the equity degree of the earth as a regional system and to propose policies to regulate it.In this paper, we reviewed the
relevant literature, then collected the required data and performed data pre-processing. Next, for the problem we faced, we developed
a model that can assess the degree of equity of any regional system. In this model, we combined subjective hierarchical analysis with
objective entropy weighting to obtain the weights of each indicator, and then calculated the IP and OP (Input and Output) for each
country using the TOPSIS integrated evaluation method. By introducing the Pearson correlation linear coefficients fitted with the
one-dimensional linear regression, the degree of global equity was judged by judging the magnitude of the one-dimensional linear
regression coefficients. Then, we applied this World Resource Equity Assessment Model to 10 countries. we made predictions for
possible future visions of asteroid mining for pre-policy interventions and post-policy interventions.
Between Tradition and Modernity:A Study on the Changes of Shanghai Citizens' Social Life in the Late Qing Dynasty——Focus on the Advertisement of The Shen Daily
Authors: Cui Shuchang 
Published: July 2022

As a commercial newspaper,The Shen Daily has paid great attention to the publication of advertisements since its inception.
With the changes of social life, the content and form of The Shen Daily advertising have evolved continuously. The social life of the
Shanghai people in the late Qing Dynasty has undergone earth shaking changes in both material and spiritual aspects. As the first group
of capital owners, The city impacted by justice economy has become an epitome of the evolution of urban social life in modern China.
Analysis of CHOPPIN’s ETUDE Op.25，No.2
Authors: Meng Xianzheng 
Published: July 2022

Choppin is one of the most influential and popular piano composers in history. He was a representative of Europe in
romantic music. He composed 27 piano etudes, which took the piano art to a higher level. Op. 25, No. 2 is the second etude in
Choppin’s Etude Op. 25, which is an etude in F minor.