bluuebunny/crossref_metadata_2025_split huggingface dataset:
Segmental Yttrium-90 Radioembolization as an Initial Treatment for Solitary Unresectable HCC
Authors: Rothenberger Natalie J. , Yu Qian , Ramasamy Shakthi K. , Van Ha Thuong , Zangan Steven , Navuluri Rakesh , Ahmed Osman 
Published: December 2022

Abstract
Objectives To evaluate the objective response rate (ORR), time to progression (TTP), and overall survival (OS) in patients with unresectable solitary HCC less than 5 cm who were treated with 90Y glass microspheres infused at a segmental level.
Materials and Methods Single-institution retrospective study of 35 patients with unresectable HCC deemed not suitable for percutaneous ablation who underwent segmental transarterial radioembolization (TARE) treatment. Eligibility criteria included patients with solitary, unilobar, < 5 cm unresectable HCC lesions who underwent TARE as a primary treatment strategy between November 2012 and April 2020. Imaging follow-up was performed on each patient at 3-, 6-, and 12 months post-treatment. Local and the overall tumor response was evaluated using mRECIST criteria, and primary endpoints were ORR, TTP, and OS. Adverse events (AEs) were graded for severity using the Common Terminology Criteria for Adverse Events (CTCAE) v.5.0.
Statistical Analysis Patient demographics, baseline characteristics, and treatment characteristics were analyzed using descriptive statistics. Predictors of survival were analyzed with Cox proportional hazards regression. Kaplan–Meier analysis was used to evaluate OS.
Results Median tumor size was 3 cm (range: 1.0-4.8 cm) in the 35 patients studied, with 25.7% (9/35) being the Eastern Cooperative Oncology Group (ECOG) 0 and 62.9% (22/35) ECOG 1. Most patients (88.5%, 31/35) were of the Barcelona Clinic Liver Cancer (BCLC) stage C, with one patient each classified as BCLC-A and BCLC-0, respectively. For 34.2% (12/35), TARE functioned as a bridge to transplantation. Transplanted patients exhibited a median pathologic necrosis of 98% (IQR 7.5). Combined ORR for local and overall mRECIST at 12 months post-TARE was 94.3% and 85.7%, respectively. All patients had a mean local TTP of 11.9 months (CI: 2.7–21.0) and global TTP of 13.2 months (CI: 6.4–20.0). Among the 14.3% (5/35) of patients who experienced AEs following treatment, 80% (4/5) were Grade 1, one patient experienced a Grade 4, and all events resolved within 1 month of treatment. Total OS at 1 year was 97%, whereas patients who underwent OLT had an OS of 100%.
Conclusion Segmental TARE was a safe and effective treatment for solitary unresectable HCC less than 5 cm. When used as a bridge to transplant, explants showed near complete pathologic necrosis of treated lesions.
Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis via the Actin Cytoskeleton
Authors: Paul Manoj , Golla Kalyan , Kim Hugh 
Published: December 2022

Background and Objective The mechanisms underlying platelet granule release are not fully understood. The actin cytoskeleton serves as the platelet's structural framework that is remodeled upon platelet activation. Gelsolin is a calcium-dependent protein that severs and caps existing actin filaments although its role in modulating platelet granule exocytosis is unknown.Methods The hemostatic function of wild-type (WT) and gelsolin null (Gsn−/− ) mice was measured ex vivo by rotational thromboelastometry analysis of whole blood. Platelets were purified from WT and Gsn−/− mouse blood and activated with thrombin. Platelet aggregation was assessed by light-transmission aggregometry. Clot retraction was measured to assess outside-in integrin signaling. Adenosine triphosphate (ATP) release and surface P-selectin were measured as markers of dense- and α-granule secretion, respectively.Results The kinetics of agonist-induced aggregation, clot retraction, and ATP release were accelerated in Gsn−/− platelets relative to WT. However, levels of surface P-selectin were diminished in Gsn−/− platelets. ATP release was also accelerated in WT platelets pretreated with the actin-depolymerizing drug cytochalasin D, thus mimicking the kinetics observed in Gsn−/− platelets. Conversely, ATP release kinetics were normalized in Gsn−/− platelets treated with the actin polymerization agonist jasplakinolide. Rab27b and Munc13–4 are vesicle-priming proteins known to promote dense granule secretion. Co-immunoprecipitation indicates that the association between Rab27b and Munc13–4 is enhanced in Gsn−/− platelets.Conclusions Gelsolin regulates the kinetics of hemostasis by modulating the platelet's actin cytoskeleton and the protein machinery of dense granule exocytosis.
Circumferential Endoscopic Submucosal Dissection of long-segment Barrett's Esophagus with Multifocal High-Grade Dysplasia
Authors: Sud Sukrit , Mishra Smruti Ranjan , Sud Randhir 
Published: December 2022

AbstractIn a case of long-segment Barrett's esophagus with multifocal high-grade dysplasia with multiple comorbidities, circumferential endoscopic submucosal dissection was performed. Following the procedure, the esophageal stricture was also managed.
On the choice of entropy variables in multifield inflation
Authors: Cicoli Michele , Guidetti Veronica , Muia Francesco , Pedro Francisco G , Paolo Vacca Gian 
Published: December 2022

AbstractWe discuss the usefulness and theoretical consistency of different entropy variables used in the literature to describe isocurvature perturbations in multifield inflationary models with a generic curved field space. We clarify which is the proper entropy variable to be used to match the evolution of isocurvature modes during inflation to the one after the reheating epoch in order to compare with observational constraints. In particular, we find that commonly used variables, as the relative entropy perturbation or the one associated to the decomposition in tangent and normal perturbations with respect to the inflationary trajectory, even if more useful to perform numerical studies, can lead to results which are wrong by several orders of magnitude, or even to apparent destabilisation effects which are unphysical for cases with light kinetically coupled spectator fields.
Nanomechanical study of aqueous-processed h-BN reinforced PVA composites
Authors: Sahoo Priyabrata , Chaturvedi Abhishek , Ramamurty Upadrasta , Matte H S S Ramakrishna 
Published: December 2022

AbstractHexagonal boron nitride (h-BN) as a filler has significantly improved the mechanical properties of various polymers composites. Among them, polyvinyl alcohol (PVA) is particularly important for its wide range of industrial applications and biocompatibility nature. However, preparing a homogenous composite of h-BN and PVA in water is troublesome as the aqueous processing of h-BN without any additives is challenging. In this context, a pre-processing technique is used to produce an additive-free aqueous dispersion of h-BN. The uniformly dispersed composites are then prepared with different concentrations of h-BN. Free-standing thin films are fabricated using the doctor blade technique, and nanoindentation is employed to understand their deformation behaviour at smaller length scale for better understanding of micro-mechanism involved. Reduced elastic modulus and hardness of 10 wt% h-BN/PVA composite film are enhanced by ∼93% and ∼159%, respectively, compared to pristine PVA. Frequency sweep dynamic mechanical analysis is performed between 1 and 50 Hz, and the elastic properties of composite materials are found to improve significantly upon addition of h-BN nanosheets. Besides, the impact of h-BN incorporation in stress relaxation behaviour and hardness depth profiling are also investigated. The observed improvement in mechanical properties of the composites may be attributed to the uniform distribution of the nanosheets and the strong interfacial interaction between h-BN and PVA, which ensures efficient mechanical stress transfer at the interface.
Inverse problems on low-dimensional manifolds
Authors: Alberti Giovanni S , Arroyo Ángel , Santacesaria Matteo 
Published: December 2022

Abstract
We consider abstract inverse problems between infinite-dimensional Banach spaces. These inverse problems are typically nonlinear and ill-posed, making the inversion with limited and noisy measurements a delicate process. In this work, we assume that the unknown belongs to a finite-dimensional manifold: this assumption arises in many real-world scenarios where natural objects have a low intrinsic dimension and belong to a certain submanifold of a much larger ambient space. We prove uniqueness and Hölder and Lipschitz stability results in this general setting, also in the case when only a finite discretization of the measurements is available. Then, a Landweber-type reconstruction algorithm from a finite number of measurements is proposed, for which we prove global convergence, thanks to a new criterion for finding a suitable initial guess.
These general results are then applied to several examples, including two classical nonlinear ill-posed inverse boundary value problems. The first is Calderón’s inverse conductivity problem, for which we prove a Lipschitz stability estimate from a finite number of measurements for piece-wise constant conductivities with discontinuities on an unknown triangle. A similar stability result is then obtained for Gel’fand-Calderón’s problem for the Schrödinger equation, in the case of piece-wise constant potentials with discontinuities on a finite number of non-intersecting balls.
Adaptive noise reduction for power Doppler imaging using SVD filtering in the channel domain and coherence weighting of pixels
Authors: Pialot Baptiste , Lachambre Célestine , Mur Antonio Lorente , Augeul Lionel , Petrusca Lorena , Basarab Adrian , Varray François 
Published: December 2022

Abstract

Objective. Ultrafast power Doppler (UPD) is an ultrasound method that can image blood flow at several thousands of frames per second. In particular, the high number of data provided by UPD enables the use of singular value decomposition (SVD) as a clutter filter for suppressing tissue signal. Notably, is has been demonstrated in various applications that SVD filtering increases significantly the sensitivity of UPD to microvascular flows. However, UPD is subjected to significant depth-dependent electronic noise and an optimal denoising approach is still being sought. Approach. In this study, we propose a new denoising method for UPD imaging: the Coherence Factor Mask (CFM). This filter is first based on filtering the ultrasound time-delayed data using SVD in the channel domain to remove clutter signal. Then, a spatiotemporal coherence mask that exploits coherence information between channels for identifying noisy pixels is computed. The mask is finally applied to beamformed images to decrease electronic noise before forming the power Doppler image. We describe theoretically how to filter channel data using a single SVD. Then, we evaluate the efficiency of the CFM filter for denoising in vitro and in vivo images and compare its performances with standard UPD and with three existing denoising approaches. Main results. The CFM filter gives gains in signal-to-noise ratio and contrast-to-noise ratio of up to 22 dB and 20 dB, respectively, compared to standard UPD and globally outperforms existing methods for reducing electronic noise. Furthermore, the CFM filter has the advantage over existing approaches of being adaptive and highly efficient while not requiring a cut-off for discriminating noise and blood signals nor for determining an optimal coherence lag. Significance. The CFM filter has the potential to help establish UPD as a powerful modality for imaging microvascular flows.
Effects of AlN/GaN superlattice buffer layer on performances of AlGaN/GaN HEMT grown on silicon for sub-6 GHz applications
Authors: Hieu Le Trung , Hsu Heng-Tung , Chiang Chung-Han , Panda Debashis , Lee Ching-Ting , Lin Chun-Hsiung , Chang Edward Yi 
Published: December 2022

Abstract
In this study, the effects of AlN/GaN superlattice (SL) thickness on performances of AlGaN/GaN high electron mobility transistor (HEMT) heterostructure grown by metal-organic chemical vapor deposition on silicon is investigated. Stress in GaN is controlled by varying the total thickness of the AlN/GaN SL. Improved crystal quality and surface roughness accomplished with 2200 nm-thick AlN/GaN SL, leads to an increase in high electron mobility (1760 cm2 (V s)−1) as well as two-dimensional electron gas concentration (1.04 × 1013 cm−2). AlGaN/GaN metal–insulator-semiconductor HEMT (MIS-HEMT) fabricated on the heterostructure with SL buffer layer exhibits a significant improvement in maximum saturation current of 1100 ± 29 mA mm−1 at V
GS = 0 V and a low on-resistance of 4.3 ± 0.15 Ω mm for the optimized AlN/GaN SL. The 2200 nm-thick AlN/GaN SL supports the growth of stress-free GaN heterostructure, which can reduce the insertion loss for sub-6 GHz radio frequency (RF) applications. This GaN HEMT structure based on SL buffer layer is suitable for low-frequency RF power applications.
Impact of ion implantation and laser processing parameters on carrier lifetimes in gold-hyperdoped silicon
Authors: Dissanayake Sashini Senali , Chow Philippe K , Lim Shao Qi , Yang Wenjie , Fiutak Rhoen , Williams Jim S , Warrender Jeffrey M , Sher Meng-Ju 
Published: December 2022

Abstract
In recent years, infrared photodetectors using silicon hyperdoped with deep-level dopants started to demonstrate extended light detection beyond the silicon’s absorption edge. The reported responsivities or external quantum efficiencies, however, are typically low. Focusing on gold-hyperdoped silicon and using time-resolved terahertz spectroscopy, a non-contact photoconductivity measurement, we investigated how hyperdoping parameters affect charge carrier lifetimes. Correlating the observed lifetime characteristics with dopant distribution profiles, we identify factors that impact carrier lifetime most significantly. Specifically, the charge carrier lifetime reduces with increasing gold concentrations, increasing ion implantation energies, and increasing pulsed-laser melting fluences. Both ion implantation energy and laser fluence affect the dopant incorporation depths. The total gold dose implanted and laser fluence affect the carrier distribution profile, particularly the concentration spike toward the surface. Oxide passivation and the number of laser pulses do not impact the carrier lifetime significantly. Our findings benefit future device developments.
Exploring the structural and magnetic trends in Ba0.9Sm0.1Fe12−xAlxO19 M-type Hexaferrites
Authors: Asif Sana Ullah , Ranjha Qasim Ali , Ghori Ubaid-ur-Rehman , Nisa Mehrun , Ahmad Muhammad Saeed , Bukhari Mehak , Jabeen Nawishta , Hussain Ahmad , Hassan NajamUl , Ahmed Fahim 
Published: December 2022

Abstract
The current study describes the structural and magnetic properties of Ba0.9Sm0.1Fe12−x
Al
x
O19 (x = 0.0, 0.5, 1.0, 2.0, 3.0) M-type hexaferrites. The conventional ceramic route was implied to prepare all the nominal samples. Morphological analysis suggested the non-presence of secondary phases as well as the formation of the hexaferrites material. X-ray Diffraction technique was used for structural analysis from which microstructural parameters are calculated and discussed. Magnetic properties are measured at room temperature. The saturation magnetization (Ms) and coercivity (Hc) values show a cyclic and converse trend for synthesized samples. Firstly, a decrease in Ms and an increase in Hc was observed up to intermediate dopant incorporation and becomes converse for higher doping levels. The maximum coercivity and minimum magnetization are observed for Ba0.9Sm0.1Fe11Al1O19. The c/a and Mr/Ms ratio suggest the formation of perfect M-type hexaferrites. This work suggests that synthesized material is a good option for magnetic applications e.g., transformer and inductor cores, microwave devices, recording heads, and magnetic shielding.
Stochastic formalism for U(1) gauge fields in axion inflation
Authors: Fujita Tomohiro , Mukaida Kyohei , Tada Yuichiro 
Published: December 2022

Abstract
We develop the stochastic formalism for U(1) gauge fields that has the Chern-Simons coupling to a rolling pseudo-scalar field during inflation.
The Langevin equations for the physical electromagnetic fields are derived and the analytic solutions are studied. Using numerical simulation we demonstrate that the electromagnetic fields averaged over the Hubble scale continuously change their direction and their amplitudes fluctuate around the analytically obtained expectation values.
Though the isotropy is spontaneously broken by picking up a particular local Hubble patch, each Hubble patch is understood independent and the isotropy is conserved globally by
averaging all the Hubble patches.
Pair production in inhomogeneous electric fields with phase modulation
Authors: Hu Li-Na , Amat Orkash , Li Lie-Juan , Mohamedsedik Melike , Xie B S 
Published: December 2022

Abstract
Electron-positron pair production in spatial inhomogeneous electric fields with sinusoidal phase modulation is studied within the Dirac-Heisenberg-Wigner formalism. The focus is on discussing the effects of the modulation parameters on the momentum spectrum and the reduced particle number at various spatial scales. For the momentum spectrum, the interference effect becomes more and more remarkable with the increase of modulated amplitude or frequency, while the symmetry is severely destroyed with modulated amplitude. For the reduced particle number, it is greatly enhanced by about a few times and evenly one order of magnitude when modulation parameters are applied. Moreover, the effect of spatial scales on the reduced particle number is carefully examined, and it is found that it increases rapidly at small spatial scales, while it tends to be a constant at large spatial scales. We also obtain the optimal pair production that can be achieved through different modulations. These results can provide a possibility for realizing the optimal pair production by combining the advantages of field spatial inhomogeneity with different choices of phase modulation.
Development and analysis of coatings cavitation erosion model by controlling changes in the acoustic properties of liquid media in limited volumes with resonant dimensions
Authors: Khmelev V N , Barsukov R V , Golykh R N , Barsukov A R 
Published: December 2022

Abstract
The article considers the influence of the extent of cavitation wear of materials and their coatings on the acoustic properties of the sounded liquid media in a limited volume. The model of an liquid media bounded by a volume with resonant dimensions is considered based on an electromechanical analogy system. The parameters and characteristics of the sounded liquid media most sensitive to changes in the dimensions of the volumes confining them as a result of their cavitation erosion are determined.
Onomasiological modeling in the information field
Authors: Bolbakov R G , Sinitsyn A V , Ya Tsvetkov V 
Published: December 2022

Abstract
The article investigates onomasiological modeling in the information field. It briefly describes the information field as an integral model of reality. It is shown that there are more relations in the information field than in reality. This ensures the integration of models. Onomasiological modeling is based on the transfer of linguistic methods to computer science. The article introduces the notion of “onomasiological information modeling”. The peculiarity of onomasiological information modeling is that it allows to realize simultaneously three kinds of modeling: semantic, systematic, and descriptive. To realize this possibility, onomasiological information modeling must include three groups of information units: semantic, systemic, and descriptive.
Assessment of the concentration of wear products of bearing elements
Authors: Juraeva Gulchehra , Djabbarova Mukaddas 
Published: December 2022

Abstract
The article presented by the author considers the greatest wear along the arc of the contact of the bearing ring with the ball is observed on the surface where there is more slippage, i.e. on the face of the groove of the rings. The problem often lies in the low durability of the bearing supports. The authors of this article are invited to analytically evaluate the durability of the bearing with additional consideration of the regularity of changes in the concentration of wear products in the oil of the unit. Uneven load distributions and different elastic constants of materials used for the outer ring and balls, and further with the subsequent improved correction of the resource, which are carried out in accordance with modern requirements. Such a correction involves not only taking into account the impact of lubrication conditions and oil contamination on the bearing life, but also modifying the resource in relation to the fatigue stress limit to the dynamic equivalent load, taking into account many factors of influence.
Mathematical model for estimation the characteristics of the noise immunity
Authors: Mehdiyeva Almaz , Quliyeva Sevinj 
Published: December 2022

Abstract
The important issues or the data transmission systems are the harmful effect of various sources of interference in the communication channel and problem of increasing noise immunity in conditions of linear distortion in development of modern systems. In order to improve the reliability of an accuracy characteristics of receiving of information, a mathematical model for assessing the stability to interference with incoherent receiving in telecommunication systems operating under the influence of unintentional interference sources is proposed. The mathematical model takes into account the quality of communication, spectral efficiency, modulation scheme and coding method when providing multimedia services to users.
Mathematical model of hardening the disk-shaped saw teeth with laser beams
Authors: Abrorov Akbar , Kurbonov Fazliddin , Teshaev Mukhsin , Kuvoncheva Matluba , Saidov Khasan 
Published: December 2022

Abstract
The mathematical model of hardening the disk-shaped saw teeth with laser beams has been developed, and in terms of results of theoretical research based on this mathematical model, it has shown that it is advisable to use laser heat treatment technology for disc saws. At the same time, elements with a larger mass are less likely to collide with an increase in mass during operation. If the mass of the element increases by two times, the probability of collision decreases by three times. In general, it has been known that thermal treatment of the material with laser beams reduces the probability of damage to the saw teeth by 1.33 times, which in turn leads to an increase in the service life of saws. Graph of the dependence of changes in microhardness when load resistance is increased by changing the specific parameters by sharpening disc saw materials using laser beams has been developed. The 3D image shows the load resistance of the saw material, the mass of the element acting on it and the connection of its impact surface. Surfaces exposed to strong impact are four times smaller than the standard material with increased material strength, i.e. resistance to hard elements is increased by four times.