bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Note: Demographic Change on the United States Coast, 2020–2100
Authors: Hauer Mathew E. , Saunders R. Kyle , Shtob Daniel 
Published: July 2022

Abstract
Prospective demographic information of the United States is limited to national-level analyses and subnational analyses of the total population. With nearly 40% of the U.S. population being residents of coastal areas, understanding the anticipated demographic changes in coastal counties is important for long-range planning purposes. In this research note, we use long-range, county-level population projections based on a simplified cohort-component method to discuss demographic changes by age, sex, and race and ethnicity for coastal counties between 2020 and the end of the century, and we compare these changes to inland counties. Presently, coastal counties are statistically significantly different from inland counties by race and ethnicity (more diverse) and sex (more women) but not by age, yet by 2025, we expect coastal counties to become significantly older than inland counties. We note several important trajectories of predicted demographic outcomes in coastal counties across the remainder of the century: (1) the non-Hispanic White population is expected to decrease, both numerically and as a percentage of the population; (2) the population older than 65 is projected to increase, both numerically and as a percentage of the population; and (3) the ratio of women to men remains constant over the century at 1.03. These trends combine to suggest that the future U.S. coastline will likely be both increasingly diverse racially and ethnically and significantly older than it is today.
Predicting compound-protein interaction using hierarchical graph convolutional networks
Authors: Bui-Thi Danh , Rivière Emmanuel , Meysman Pieter , Laukens Kris 
Published: July 2022

Motivation
Convolutional neural networks have enabled unprecedented breakthroughs in a variety of computer vision tasks. They have also drawn much attention from other domains, including drug discovery and drug development. In this study, we develop a computational method based on convolutional neural networks to tackle a fundamental question in drug discovery and development, i.e. the prediction of compound-protein interactions based on compound structure and protein sequence. We propose a hierarchical graph convolutional network (HGCN) to encode small molecules. The HGCN aggregates a molecule embedding from substructure embeddings, which are synthesized from atom embeddings. As small molecules usually share substructures, computing a molecule embedding from those common substructures allows us to learn better generic models. We then combined the HGCN with a one-dimensional convolutional network to construct a complete model for predicting compound-protein interactions. Furthermore we apply an explanation technique, Grad-CAM, to visualize the contribution of each amino acid into the prediction.

Results
Experiments using different datasets show the improvement of our model compared to other GCN-based methods and a sequence based method, DeepDTA, in predicting compound-protein interactions. Each prediction made by the model is also explainable and can be used to identify critical residues mediating the interaction.
The association of sun exposure, ultraviolet radiation effects and other risk factors for pterygium (the SURE RISK for pterygium study) in geographically diverse adult (≥40 years) rural populations of India -3rd report of the ICMR-EYE SEE study group
Authors: Tandon Radhika , Vashist Praveen , Gupta Noopur , Gupta Vivek , Yadav Saumya , Deka Dipali , Singh Sachchidanand , Vishwanath K. , Murthy G. V. S. 
Published: July 2022

Purpose
To determine the prevalence and risk factors for pterygium in geographically diverse regions of India.

Methods
A population-based, cross-sectional multicentric study was conducted in adults aged ≥40 years in plains, hilly and coastal regions of India. All participants underwent a detailed questionnaire-based assessment for sun exposure, usage of sun protective measures, exposure to indoor smoke, and smoking. Detailed ocular and systemic examinations were performed. Pterygium was diagnosed and graded clinically by slit-lamp examination. Association of pterygium with sociodemographic, ophthalmological, and systemic parameters was assessed. Physical environmental parameters for the study period were estimated.

Results
Of the 12,021 eligible subjects, 9735 (81% response rate) participated in the study. The prevalence of pterygium in any eye was 13.2% (95% CI: 12.5%-13.9%), and bilateral pterygium was 6.7% (95% CI: 6.2–7.2). The prevalence increased with age (<0.001) irrespective of sex and was highest in those aged 60–69 years (15.8%). The prevalence was highest in coastal (20.3%), followed by plains (11.2%) and hilly regions (9.1%). On multi-logistic regression, pterygium was positively associated with coastal location (P<0.001), illiteracy (P = 0.037), increasing lifetime sun exposure (P<0.001), and negatively associated with BMI ≥25 kg/m2 (P = 0.009).

Conclusion
Pterygium prevalence is high in the rural Indian population. The association of pterygium with several potentially modifiable risk factors reflects its multifactorial etiology and provides targets for preventive measures.
Think about your friends and family: The disparate impacts of relationship-centered messages on privacy concerns, protective health behavior, and vaccination against Covid-19
Authors: Hanson Clara K. , Liu Kayuet 
Published: July 2022

Objective
To understand which factors affect how willing people are to share their personal information to combat the Covid-19 pandemic, and compare them to factors that affect other public health behaviors.

Method
We analyze data from three pre-registered online experiments conducted over eight months during the Covid-19 pandemic in the United States (April 3 2020 –November 25, 2020). Our primary analysis tests whether support for data sharing and intention to practice protective behavior increase in response to relationship-centered messages about prosociality, disease spread, and financial hardship. We then conduct a secondary correlational analysis to compare the demographic and attitudinal factors associated with willingness to share data, protective behavior, and intent to get vaccinated. Our sample (N = 650) is representative to socio-demographic characteristics of the U.S. population.

Results
We find the altruistic condition increased respondents’ willingness to share data. In our correlational analysis, we find interactive effects of political ID and socio-demographic traits on likelihood to share data. In contrast, we found health behavior was most strongly associated with political ID, and intent to vaccinate was more associated with socio-demographic traits.

Conclusions
Our findings suggest that some public health messaging, even when it is not about data sharing or privacy, may increase public willingness to share data. We also find the role of socio-demographic factors in moderating the effect of political party ID varies by public health behavior.
Bone marrow involvement in patients with metastatic castration sensitive prostate cancer
Authors: Shahait Mohammed , Abu-hijlih Ramiz , Salamat Alaa , Abou Heidar Nassib , Sharaf Baha’ , Abuhijla Fawzi , Salah Samer 
Published: July 2022

Introduction
The clinical significance of bone marrow (BM) metastasis in prostate cancer as well as impact on oncological prognosis is unclear. We aim to assess the prevalence and clinical outcomes of BM metastasis at initial presentation of metastatic castrate sensitive prostate cancer (CSPC).

Patients and methods
Retrospective chart review of newly diagnosed metastatic CSPC patients was performed with collection of clinicopathologic and radiologic characteristics. Descriptive univariate and multivariate analysis was performed as well as survival measures (OS and PFS), which was done using the Kaplan-Meier survival and the Log-rank test.

Results
189 patients were eligible, of which, eleven patients (6%) had biopsy proven BM involvement at diagnosis. There was a trend to poorer PFS and OS in patients with BM involvement but not statistically significant; however, factors that correlated with inferior PFS and OS in the multivariate analysis included ECOG PS, ALP, and Hb.

Conclusion
BM metastasis in prostate cancer may lead to poorer survival. Clinical features including poor performance status, anemia, and elevated ALP, could guide bone marrow biopsies in the future to diagnose bone marrow metastasis at an earlier stage.
The optimum parameters and neuroimaging mechanism of repetitive transcranial magnetic stimulation to post-stroke cognitive impairment, a protocol of an orthogonally-designed randomized controlled trial
Authors: Li Ling-Xin , Lu Jing-Kang , Li Bao-Jin , Gao Qiang , He Cheng-Qi , Zhang Shi-Hong , Zhao You-Jin , He Shuai , Wen Qian 
Published: July 2022

Objective
Repetitive Transcranial Magnetic Stimulation (rTMS) has been used in cognition impairment due to various neuropsychiatric disorders. However, its optimum parameters and the neuroimaging mechanism are still of uncertainty. In order to simulate a study setting as close to real world as possible, the present study introduces a new orthogonally-designed protocol, consisting of the rTMS intervention with four key parameters (stimulating site, frequency, intensity and pulse number) and three different levels in each one, and aims to investigate the optimum parameters and the brain activity and connectivity in default mode network (DMN), dorsal attention network (DAN), central executive network (CEN) following rTMS intervention to post-stroke cognition impairment (PSCI).

Methods
A single-center, orthogonally-designed, triple-blind randomized controlled trial will be conducted and forty-five PSCI patients will be recruited and randomly assigned to one of nine active rTMS groups based on four rTMS paraments: stimulating site, frequency, intensity and pulse number. Neuropsychological, activities of daily living, quality of life and functional magnetic resonance imaging (fMRI) evaluations were be performed pre-, post- and 3 months after rTMS.

Discussion
This study evaluates the optimum parameters of rTMS for patients with post-stroke cognition impairment and explores the alteration of neural function in DMN, DAN, CEN brain network. These results would facilitate the standardized application of rTMS in cognition impairment rehabilitation.
Susceptibility to movement-evoked pain following resistance exercise
Authors: Kodesh Einat , Sirkis-Gork Anat , Mankovsky-Arnold Tsipora , Shamay-Tsoory Simone , Weissman-Fogel Irit 
Published: July 2022

Objective
To investigate the: (1) role of basic muscle pain sensitivity and psychological factors in the prediction of movement-evoked pain (MEP) following delayed onset muscle soreness (DOMS), and (2) association of MEP with changes in systemic muscle pain sensitivity following DOMS induction.

Methods
Fifty-one participants were assigned to either eccentric resistance exercise or control groups. They completed questionnaires evaluating psychological distress and underwent muscle pain sensitivity evaluation by the pressure pain threshold (PPT) test at the exercised and remote muscles, before and 24 hours following the intervention. MEP intensity was determined in response to lifting a 3kg canister using a visual analogue scale (VAS).

Results
The exercise group demonstrated MEP intensity of 5/10 on VAS and reduced PPTs at the main exercised muscle (p<0.001). A regression tree analyses revealed that the level of anxiety trait predicted a higher MEP intensity. A secondary analysis showed that 53% participants who were DOMS responders (MEP > mild intensity; ≥ 3/10 VAS) exhibited decreased PPTs in the exercised (p<0.001) and remote (p = 0.027) muscles following eccentric exercise. Characterization of DOMS responders revealed that, at baseline, they had lower PPTs in the exercised (p = 0.004) and remote (p = 0.001) muscles and reported higher psychological distress i.e., anxiety trait and depression symptoms (p<0.05), compared to non-responders. A regression analysis revealed that lower PPT or high levels of anxiety trait increased the probability to become a responder (p = 0.001).

Conclusions
Susceptibility to MEP following DOMS is determined by muscle pain hypersensitivity and high levels of anxiety trait. MEP at the early stage of DOMS is linked with an increase in systemic muscle pain sensitivity suggestive of central mechanisms. This knowledge is valuable in translating science into clinical musculoskeletal pain management.
Visual prognosis of submacular hemorrhage secondary to age-related macular degeneration: A retrospective multicenter survey
Authors: Inoue Naomi , Kato Aki , Araki Takashi , Kimura Takeshi , Kinoshita Takamasa , Okamoto Fumiki , Murakami Tomoya , Mitamura Yoshinori , Sakamoto Taiji , Miki Akiko , Takamura Yoshihiro , Matsubara Hisashi , Tsujinaka Hiroki , Gomi Fumi , Yasukawa Tsutomu 
Published: July 2022

Purpose
To investigate the clinical features, treatment options, and visual outcomes of submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD).

Design
A retrospective, observational case series.

Methods
Setting: Multicenter institutional setting. Patient Population: A total of 127 patients (127 eyes; 88 men, 39 women; (mean age, 74.2 years)) diagnosed with AMD-associated SMHs exceeding 2 disc diameters involving the fovea. Observation: The AMD types, previous treatments, treatment options, anatomic findings, and best-corrected visual acuity (BCVA) were assessed. Main Outcome Measures: Clinical features, treatment options, and visual outcomes of SMHs secondary to nAMD.

Results
Thirty-two eyes had typical AMD, 94 eyes polypoidal choroidal vasculopathy (PCV), and one eye retinal angiomatous proliferation. Eighty-five eyes were treatment-naïve; 42 eyes were treated previously: anti-vascular endothelial growth factor (VEGF) therapy (n = 26), photodynamic therapy (n = 3), and combined therapy (n = 13). Treatment of SMHs included vitrectomy (36 eyes), pneumatic displacement (49 eyes), and anti-VEGF monotherapy (42 eyes). The final BCVA improved significantly in treatment-naïve cases from 0.86 to 0.62 logarithm of the minimal angle of resolution (logMAR) unit (Snellen equivalent from 20/145 to 20/83) and from 0.80 to 0.56 (Snellen equivalent from 20/126 to 20/73) in PCV cases. Meanwhile, the BCVA logMAR values improved from 1.15 to 0.75 (Snellen equivalent from 20/283 to 20/112) and from 0.87 to 0.63 (Snellen equivalent from 20/148 to 20/85) in eyes that underwent vitrectomy or pneumatic displacement, respectively. In eyes with BCVAs between 20/133 to 20/40 at SMH onset, the final VA in the pneumatic displacement group was better than in the anti-VEGF monotherapy group. One eye had a retinal detachment and 1 eye had a macular hole in the vitrectomy group, and 5 eyes had a vitreous hemorrhage in the pneumatic displacement group.

Conclusions
The recommended treatment for SMHs secondary to nAMD exceeding 2 disc area and with BCVA below 20/40 is vitrectomy or pneumatic displacement for visual improvement.
Incidence, prevalence, and national burden of interstitial lung diseases in India: Estimates from two studies of 3089 subjects
Authors: Dhooria Sahajal , Sehgal Inderpaul Singh , Agarwal Ritesh , Muthu Valliappan , Prasad Kuruswamy Thurai , Kathirvel Soundappan , Garg Mandeep , Bal Amanjit , Aggarwal Ashutosh Nath , Behera Digambar 
Published: July 2022

Background and objective
The epidemiology of interstitial lung diseases (ILDs) in developing countries remains unknown. The objective of this study was to estimate the incidence, prevalence, and national burden of ILDs in India.

Methods
Data of consecutive subjects (aged >12 years) with ILDs included in a registry between March 2015 and February 2020 were analyzed retrospectively. The proportion of each ILD subtype was determined. The crude annual incidence and prevalence of ILDs for our region were estimated. Subsequently, the primary estimates of the national annual incident and prevalent burden of ILD and its subtypes were calculated. Alternative estimates for each ILD subtype were calculated using the current and a large, previous Indian study (n = 1,084). Data were analyzed using SPSS version 22 and are presented descriptively.

Results
A total of 2,005 subjects (mean age, 50.7 years; 47% men) were enrolled. Sarcoidosis (37.3%) was the most common ILD subtype followed by connective tissue disease (CTD)-related ILDs (19.3%), idiopathic pulmonary fibrosis (IPF, 17.0%), and hypersensitivity pneumonitis (HP, 14.4%). The crude annual incidence and prevalence of ILDs were 10.1–20.2 and 49.0–98.1, respectively per 100,000 population. The best primary estimates for the crude national burden of all ILDs, sarcoidosis, CTD-ILD, IPF, HP, and other ILDs (in thousands) were 433–867, 213–427, 75–150, 51–102, 54–109, and 39–78. The respective alternative estimates (in thousands) were sarcoidosis, 127–254; CTD-ILD, 81–162; IPF, 46–91; HP, 130–261; other ILDs, 49–98.

Conclusion
In contrast to developed countries, sarcoidosis and HP are the ILDs with the highest burden in India.
Study protocol: International joint research project ‘climate change resilience of Indigenous socioecological systemsʼ (RISE)
Authors: García Molinos Jorge , Gavrilyeva Tuyara , Joompa Pattamaporn , Narita Daiju , Chotiboriboon Sinee , Parilova Varvara , Sirisai Solot , Okhlopkov Innokentiy , Zhang Zhixin , Yakovleva Natalia , Kongpunya Prapa , Gowachirapant Sueppong , Gabyshev Viacheslav , Kriengsinyos Wantanee 
Published: July 2022

BackgroundAnthropogenic changes in the environment are increasingly threatening the sustainability of socioecological systems on a global scale. As stewards of the natural capital of over a quarter of the world’s surface area, Indigenous Peoples (IPs), are at the frontline of these changes. Indigenous socioecological systems (ISES) are particularly exposed and sensitive to exogenous changes because of the intimate bounds of IPs with nature. Traditional food systems (TFS) represent one of the most prominent components of ISES, providing not only diverse and nutritious food but also critical socioeconomic, cultural, and spiritual assets. However, a proper understanding of how future climate change may compromise TFS through alterations of related human-nature interactions is still lacking. Climate change resilience of indigenous socioecological systems (RISE) is a new joint international project that aims to fill this gap in knowledge.Methods and designRISE will use a comparative case study approach coupling on-site socioeconomic, nutritional, and ecological surveys of the target ISES of Sakha (Republic of Sakha, Russian Federation) and Karen (Kanchanaburi, Thailand) people with statistical models projecting future changes in the distribution and composition of traditional food species under contrasting climate change scenarios. The results presented as alternative narratives of future climate change impacts on TFS will be integrated into a risk assessment framework to explore potential vulnerabilities of ISES operating through altered TFS, and possible adaptation options through stakeholder consultation so that lessons learned can be applied in practice.DiscussionBy undertaking a comprehensive analysis of the socioeconomic and nutritional contributions of TFS toward the sustainability of ISES and projecting future changes under alternative climate change scenarios, RISE is strategically designed to deliver novel and robust science that will contribute towards the integration of Indigenous issues within climate change and sustainable agendas while generating a forum for discussion among Indigenous communities and relevant stakeholders. Its goal is to promote positive co-management and regional development through sustainability and climate change adaptation.
Idiosyncratic Drug-Induced Liver Injury Associated With and Without Drug Reaction With Eosinophilia and Systemic Symptoms
Authors: Devarbhavi Harshad , Kurien Sunu Sara , Raj Sujata , Patil Mallikarjun , Gowda Vinod , Kothari Ksheetij , Singh Rajvir 
Published: July 2022

INTRODUCTION:
Immunoallergic drug-induced liver injury (DILI) presenting with features of drug reaction with eosinophilia and systemic symptoms (DRESS) is a distinct phenotype. We describe the clinical characteristics, hepatitis pattern, severity, complications, and implicated medications in DILI patients with and without DRESS.

METHODS:
Using established criteria, we analyzed DILI registry patients with and without DRESS from 1998 to 2021.

RESULTS:
DILI associated with DRESS (DwD) comprised 179 among 943 cases (19%) of DILI. Compared with the cohort without DRESS, patients with DwD are more often women and have shorter latency, lesser degrees of injury (P < 0.01), and lower mortality (7.8%) than those without DRESS (16%). Antiepileptic drugs (36%), sulfonamides (19%), antituberculosis drugs (14%), antibiotics (10%), and antiretroviral drugs (8%) account for 87% of the cases of DwD.

DISCUSSION:
A limited number of drugs cause DwD, representing a fifth of patients with DILI. DwD is characterized by lesser degrees of liver injury and mortality likely because of earlier presentation.
The Religious Moderation Discourse in Social Media: Studies on Ach Dhofir Zuhry's Facebook and YouTube
Authors: Iswanto Agus , Maknun Moch Lukluil , Hidayat Roch Aris , Nugroho Muhammad Aji 
Published: July 2022

There have been many studies that discuss the use of social media for disseminating the religious ideology of both conservatism and radicalism. On the contrary, there have only been few studies that deal with how the moderate groups disseminate the discourse of religious moderation, whereas this topic is significant to be discussed in order to view the strength and the weakness as well as the contestation between each group. This article presents the production, distribution, and consumption, and the social practice of the religious moderation discourse throughout the contents delivered by the figure from the groups of moderate Islam, from the Regency of Malang. The article is based on the discourse analysis toward a number of contents that have been produced by the figure and his team over YouTube and Facebook. The study show that the production of religious moderation discourse in social media is carried out in two ways: conveying messages of religious moderation, and countering narratives of conservatism and religious radicalism. The prospect of Islamic moderation discourse holds the opportunity to gain success in countering the narration of religious radicalism. However, the success of discourse contestation is defined by the strength of their distribution.