bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the relative importance of the OxCAP-MH’s capability items differ according to mental ill-health experience?
Authors: Helter Timea Mariann , Kaltenboeck Alexander , Baumgartner Josef , Mayrhofer Franz , Heinze Georg , Sönnichsen Andreas , Wancata Johannes , Simon Judit 
Published: June 2022

Abstract
Background
Some capability dimensions may be more important than others in determining someone’s well-being, and these preferences might be dependent on ill-health experience. This study aimed to explore the relative preference weights of the 16 items of the German language version of the OxCAP-MH (Oxford Capability questionnaire-Mental Health) capability instrument and their differences across cohorts with alternative levels of mental ill-health experience.

Methods
A Best–Worst-Scaling (BWS) survey was conducted in Austria among 1) psychiatric patients (direct mental ill-health experience), 2) (mental) healthcare experts (indirect mental ill-health experience), and 3) primary care patients with no mental ill-health experience. Relative importance scores for each item of the German OxCAP-MH instrument were calculated using Hierarchical Bayes estimation. Rank analysis and multivariable linear regression analysis with robust standard errors were used to explore the relative importance of the OxCAP-MH items across the three cohorts.

Results
The study included 158 participants with complete cases and acceptable fit statistic. The relative importance scores for the full cohort ranged from 0.76 to 15.72. Findings of the BWS experiment indicated that the items Self-determination and Limitation in daily activities were regarded as the most important for all three cohorts. Freedom of expression was rated significantly less important by psychiatric patients than by the other two cohorts, while Having suitable accommodation appeared significantly less important by the expert cohort. There were no further significant differences in the relative preference weights of OxCAP-MH items between the cohorts or according to gender.

Conclusions
Our study indicates significant between-item but limited mental ill-health related heterogeneity in the relative preference weights of the different capability items within the OxCAP-MH. The findings support the future development of preference-based value sets elicited from the general population for comparative economic evaluation purposes.
Impact of COVID‐19 pandemic on foot care services in Ontario, Canada
Authors: Lu Suzanne H. , McLaren Ann‐Marie , Pinsker Ellie 
Published: June 2022

AbstractBackgroundThe COVID‐19 pandemic has directly affected the delivery of health care services in Canada, including foot care. The goal of this descriptive study was to understand the impact of the early COVID‐19 pandemic (March 2020 to April 2021) on chiropodists' and podiatrists' clinical practices and foot care service delivery in Ontario, Canada.MethodsA web‐survey was completed by participating chiropodists and podiatrists registered with the College of Chiropodists of Ontario. The survey consisted of 31 multiple choice and open‐ended items on clinical practice characteristics, foot care service delivery changes, perceived barriers during the pandemic, and its impact on clinicians. Descriptive statistics were used to characterize the sample and examine clinicians' responses, and qualitative content analysis was used to explore opened‐ended items.ResultsOf the 773 eligible clinicians, 279 participated for a response rate of 36.1%. Most respondents reported a decline in patient volume, an increase in urgent foot health problems, a financial impact on their clinical practices, an emotional impact, and substantial changes to how they provided foot care services, such as incorporating telehealth/virtual care into patient care. Factors that impact clinicians' perception of future pandemic preparedness are identified.ConclusionThis study describes foot care service delivery in Ontario, Canada during the COVID‐19 pandemic. The COVID‐19 pandemic saw an increase in urgent foot health problems, decline in patient volume, and impacted clinicians' mental health and emotional well‐being. Future studies should examine patients' experiences of foot care service delivery and maintaining their foot health during the pandemic, and further examination of factors that impact clinicians' perception of pandemic preparedness.
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival
Authors: Pedersen Christine Aaserød , Cao Maria Dung , Fleischer Thomas , Rye Morten B. , Knappskog Stian , Eikesdal Hans Petter , Lønning Per Eystein , Tost Jörg , Kristensen Vessela N. , Tessem May-Britt , Giskeødegård Guro F. , Bathen Tone F. 
Published: June 2022

AbstractBackgroundLocally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the specific types of NACT. DNA methylation is an epigenetic mechanism known to play an important role in regulating gene expression and may serve as a biomarker for treatment response and survival. We investigated the potential role of DNA methylation as a prognostic marker for long-term survival (> 5 years) after NACT in breast cancer.MethodsDNA methylation profiles of pre-treatment (n = 55) and post-treatment (n = 75) biopsies from 83 women with locally advanced breast cancer were investigated using the Illumina HumanMethylation450 BeadChip. The patients received neoadjuvant treatment with epirubicin and/or paclitaxel. Linear mixed models were used to associate DNA methylation to treatment response and survival based on clinical response to NACT (partial response or stable disease) and 5-year survival, respectively. LASSO regression was performed to identify a risk score based on the statistically significant methylation sites and Kaplan–Meier curve analysis was used to estimate survival probabilities using ten years of survival follow-up data. The risk score developed in our discovery cohort was validated in an independent validation cohort consisting of paired pre-treatment and post-treatment biopsies from 85 women with locally advanced breast cancer. Patients included in the validation cohort were treated with either doxorubicin or 5-FU and mitomycin NACT.ResultsDNA methylation patterns changed from before to after NACT in 5-year survivors, while no significant changes were observed in non-survivors or related to treatment response. DNA methylation changes included an overall loss of methylation at CpG islands and gain of methylation in non-CpG islands, and these changes affected genes linked to transcription factor activity, cell adhesion and immune functions. A risk score was developed based on four methylation sites which successfully predicted long-term survival in our cohort (p = 0.0034) and in an independent validation cohort (p = 0.049).ConclusionOur results demonstrate that DNA methylation patterns in breast tumors change in response to NACT. These changes in DNA methylation show potential as prognostic biomarkers for breast cancer survival.
Convergent validity of commonly used questions assessing physical activity and sedentary time in Swedish patients after myocardial infarction
Authors: Lönn Amanda , Kallings Lena Viktoria , Börjesson Mats , Ekblom Örjan , Ekström Mattias 
Published: June 2022

Abstract
Background
Guidelines recommend regular physical activity (PA) and decreased sedentary time (SED) for patients after myocardial infarction (MI). Therefore, valid self-assessment of PA is vital in clinical practice. The purpose of this study was to assess the convergent validity of commonly used PA and SED questions recommended by the National Board of Health and welfare (NBHW) and national SWEDEHEART-registry using accelerometers as the reference method in patients after MI.

Methods
Data were obtained 2017–2021 among Swedish men and women (180 assessments). Participants answered five commonly used PA and SED-questions (by NBHW and SWEDEHEART) and wore an accelerometer (Actigraph GT3X) for seven days. Convergent validity was assessed gradually by; Kruskall Wallis-, Sperman rho, Weighted Kappa- and ROC-analyses. Misclassification was explored by Chi-square analyses with Benjamini–Hochberg adjustment.

Results
The strongest correlation (r = 0.37) was found for the SED-GIH question (NBHW). For PA, no specific question stood out, with correlations of r = 0.31 (NBWH), and r = 0.24–0.30 (SWEDEHEART). For all questions (NBHW and SWEDEHEART), there was a high degree of misclassification (congruency 12–30%) affecting the agreement (0.09–0.32) between self-report and accelerometer assessed time. The SED-GIH, PA-index and SWEDEHEART-VPA had the strongest sensitivity for identifying individuals with high SED (0.72) or low PA (0.77 and 0.75).

Conclusion
The studied PA and SED questions may provide an indication of PA and SED level among patients with MI in clinical practice and could be used to form a basis for further dialogue and assessment. Further development is needed, since practical assessment tools of PA and SED are desirable.
Hereditary transthyretin amyloidosis: a case report
Authors: Lee Angela , Fine Nowell M. , Bril Vera , Delgado Diego , Hahn Christopher 
Published: June 2022

Abstract
Background
Hereditary transthyretin amyloidosis is an uncommon multisystem disorder caused by mutation of the transthyretin protein, leading to peripheral neuropathy often with autonomic features, cardiomyopathy, or a mixed phenotype. Multiple other organ systems can be involved with ophthalmologic, renal, hematologic, gastrointestinal, and/or genitourinary symptoms and signs. This often results in assessments by multiple specialists and significant delays before the diagnosis is recognized. With the recent advent of potentially lifesaving therapies, early diagnosis has become even more important. Our case highlights the protean aspects of this disease as well as the difficulty of making this diagnosis, especially in the absence of a clear family history.

Case presentation
We report the case of a 64-year-old man of East-Asian descent who presented with diarrhea, mild anemia, and symptoms of peripheral neuropathy. Numerous investigations and specialist evaluations did not identify a cause. Progression of neurologic symptoms and the development of new hematologic abnormalities ultimately led to consideration of hereditary transthyretin amyloidosis. The diagnosis was confirmed after re-examining previously acquired gastrointestinal biopsies and pursuing genetic testing, which confirmed a pathogenic mutation in the transthyretin gene. He was subsequently started on a novel gene-silencing therapy. On clinical follow-up 8 months after initiation of therapy, the patient described stabilization of previously progressive numbness, weakness, and weight loss with an unchanged neurologic examination and stable repeat electrophysiologic testing.

Conclusions
Hereditary transthyretin amyloidosis is a challenging disease to recognize in early stages owing to its multisystem and nonspecific manifestations. Recent approval of novel therapies highlights the importance of early diagnosis before irreversible organ damage occurs.
Amperometric method for the determination of cellulase activity and its optimization using response surface method
Authors: Nero Georg , Kivirand Kairi , Ben Othman Sana , Rinken Toonika 
Published: June 2022

AbstractCellulases are a group of enzymes, which catalyse different steps of cellulose hydrolysis, and are broadly used in industry as unpurified mixtures of several enzymes. The total activity of cellulase is defined as the ability of the enzyme to produce glucose, which is the final product of cellulose hydrolysis, and is expressed in cellulase units. However, common strategies for the determination of the cellulolytic activity of industrial cellulase preparations are based on the assessment of different steps of cellulose hydrolysis, and the results obtained with different methods are not similar. The aim of the present study was to develop an assay for the determination of cellulase activity that relies on the amperometric determination of the final product of cellulose hydrolysis glucose. The assay conditions were optimized using response surface methodology (RSM) combined with Box-Behnken design. The detection limit of the proposed method was 1.71 ± 0.06 U. We compared the results of the amperometric method with the ones obtained with the spectrophotometric method and viscosimetry in a commercial cellulose preparation.
Migrating solar diurnal tidal variability during Northern and Southern Hemisphere Sudden Stratospheric Warmings
Authors: Siddiqui Tarique A. , Chau Jorge L. , Stolle Claudia , Yamazaki Yosuke 
Published: June 2022

AbstractIn this study, the variability of the migrating solar diurnal (DW1) tide in the mesosphere-lower thermosphere (MLT) region during Northern and Southern Hemisphere (NH & SH) Sudden Stratospheric Warmings (SSWs) is investigated using Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) temperature observations and reanalysis-driven Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension (WACCM-X) simulations. The periods examined include four major NH SSWs that occurred in 2006, 2009, 2010 and 2013 and two SH SSWs that were observed in 2002 and 2019. Our analysis shows that the DW1 tide in both observations and simulations displays a reduction of amplitude at low-latitudes after the onset of NH and SH SSWs. As WACCM-X simulations qualitatively reproduce this feature of DW1 tidal variability common to both NH and SH SSWs, they have been used to examine the possible mechanism that could explain these observations in the DW1 tide. It is known that changes in the latitudinal shear of zonal winds at low-latitudes strongly affect the seasonal variation of the DW1 tide in the MLT. We show that SSW-associated changes in the latitudinal shear in the MLT could explain the observed variability of the DW1 tide during NH and SH SSWs.
Graphical Abstract
Successful open radical gastrectomy for locally advanced or metastatic gastric cancer patients who suffered from coronavirus disease 2019 during preoperative chemotherapy: a report of three cases
Authors: Nishie Naoki , Ohashi Manabu , Makuuchi Rie , Hayami Masaru , Ida Satoshi , Kumagai Koshi , Nunobe Souya , Sano Takeshi 
Published: June 2022

Abstract
Background
According to previous reports, in patients with preoperative coronavirus disease 2019 (COVID-19) infection, mortality is increased if they undergo surgery within 6 weeks of diagnosis. However, the optimal timing and preoperative examination for gastrectomy with a previous COVID-19 infection are still controversial. We experienced three cases in which patients successfully underwent open radical gastrectomy following preoperative chemotherapy even though they developed COVID-19 infection during the chemotherapy.

Case presentation
Case 1: A 58-year-old man with locally advanced gastric cancer caught COVID-19 during preoperative chemotherapy comprising 5-fluorouracil, calcium folate, oxaliplatin, and docetaxel. Although the patient had specific lung shadows indicating COVID-19 infection and deep venous thrombosis in the lower extremities, he underwent distal gastrectomy 10 weeks after the COVID-19 diagnosis. He had a good postoperative course. Case 2: A 56-year-old man with gastric cancer and lymph node and peritoneal metastasis caught COVID-19 during palliative chemotherapy comprising S-1, oxaliplatin, and trastuzumab. He underwent total gastrectomy as conversion surgery 8 weeks after COVID-19 infection. His postoperative course was uneventful. Case 3: A 55-year-old man with gastric cancer and paraaortic lymph node and liver metastases caught COVID-19 during S-1 and oxaliplatin treatment as neoadjuvant chemotherapy. He underwent distal gastrectomy, paraaortic lymph node sampling, and partial hepatectomy 8 weeks after COVID-19 infection although he had residual lung shadows and deep venous thrombosis in the lower extremities. He had an uneventful postoperative course.

Conclusions
Computed tomography for preoperative evaluation was performed for all three patients and revealed that lung shadows remained post-COVID-19 infection. Despite this finding, the patients had good operative courses and were discharged as planned. Surgery after 7 weeks from the diagnosis of COVID-19 infection can be performed safely even when patients are post-chemotherapy and have residual lung findings and deep venous thrombosis. This report may contribute to the development of a consensus on performing safe gastrectomy for advanced gastric cancer in patients previously infected with COVID-19.
Comprehensive assessment of real-time precise products from IGS analysis centers
Authors: Li Bofeng , Ge Haibo , Bu Yuhang , Zheng Yanning , Yuan Leitong 
Published: June 2022

AbstractReal-Time Precise Point Positioning (RT-PPP) has been one of the research hotspots in GNSS (Global Navigation Satellite System) community for decades. Real-time precise products of satellite orbits and clocks are the prerequisite for RT-PPP. Thus, it is of great importance to investigate the current multi-GNSS real-time precise products in State Space Representation (SSR) from different analysis centers. In this article, SSR products from 10 analysis centers are comprehensively evaluated by comparing them with the final products and performing the kinematic PPP. The results show that analysis centers CNES (Centre National D'Etudes Spatiales) and WHU (GNSS Research Center of Wuhan University) provide the most complete products with the best quality. Concerning the accuracy of real-time products for the GNSSs, the accuracies of orbit and clock products are better than 5 cm and 0.15 ns, respectively, for Global Positioning System (GPS), followed by Galileo navigation satellite system (Galileo), BeiDou-3 Navigation Satellite System (BDS-3), GLObal NAvigation Satellite System (GLONASS), and BeiDou-2 Navigation Satellite System (BDS-2). Meanwhile, the results of the RT-PPP with quad-system show that the positioning accuracies are 1.76, 1.12 and 2.68 cm in east, north, and up directions, respectively, and the convergence time to 0.1, 0.1, 0.2 m for corresponding directions is 15.35 min.
Development of a Curriculum for the Implementation of Stereotactic Radiation Therapy Programs in Middle-Income Countries
Authors: Buckley Lesley , Bacha Billel , Gaudet Marc , Haché Christiane , Lacelle Manon , Naoun Lilia , Wooster Elizabeth , Bourque Jean-Marc 
Published: June 2022

PURPOSEThe aim of this work was to develop a curriculum to be used in the implementation of stereotactic radiation therapy programs in middle-income countries. The curriculum needed to be scalable and flexible to be easily adapted to local situations.METHODSThe curriculum was developed through a partnership between multidisciplinary teams from established clinics in both middle-income and high-income countries. The curriculum development followed a nonlinear progression, allowing greater flexibility throughout the process. A blended learning model was used, combining virtual and in-person interactions.RESULTSThe initial training plan was based on a needs assessment provided by the learners and on the experience of the facilitators with stereotactic radiotherapy. The needs assessment was refined during in-person site visits at each institution which highlighted aspects of the training, such as image guidance workflows and technical specifications, that were not previously emphasized in the curriculum. Both teams found that the in-person visits were important for training purposes, but aspects of the curriculum delivery such as treatment planning and patient selection were well suited to virtual platforms. The training addressed all aspects of the stereotactic program, from patient selection to treatment, and included a review of both technical and clinical workflows.CONCLUSIONThe inclusion of contributions from both teams ensured that the curriculum covered the required elements of the stereotactic program implementation, met the needs of the learners, and was relevant to local practices. The nonlinear approach to the curriculum development allowed the flexibility to change the focus as the project progressed. The in-person visits were valuable in conducting a thorough needs assessment.
Proximity and the Management of Innovation
Authors: Glaeser Chloe Kim , Glaeser Stephen , Labro Eva 
Published: June 2022

We study the effect of proximity to corporate headquarters on the productivity of inventors and research and development (R&D) facilities. Distant inventors and R&D facilities are less productive, and plausibly exogenous reductions in the travel time from these inventors or facilities to headquarters increase their productivity and creativity. We hypothesize that these improvements in the management of innovation production occur because proximity improves monitoring, managerial ability to provide direction, relationship building that supports creativity, and information exchange, including advice from headquarters. Consequently, our results suggest that proximity can help managers balance both exploration and exploitation when overseeing innovation. Naturally, these results then beg the question of why firms do not locate all inventors and R&D facilities in close proximity to headquarters. We find that distant inventors and R&D facilities are located in areas with better general economic indicators, and especially more favorable tax rates, than headquarters, suggesting firms balance these benefits against the benefits of proximity when locating innovation production. This paper was accepted by Brian Bushee, accounting. Supplemental Material: Data and the internet appendix are available at https://doi.org/10.1287/mnsc.2022.4469 .
Climate Impact Investing
Authors: De Angelis Tiziano , Tankov Peter , Zerbib Olivier David 
Published: June 2022

This paper shows how green investing spurs companies to mitigate their carbon emissions by raising the cost of capital of the most carbon-intensive companies. Companies’ emissions decrease when the wealth share of green investors and their sensitivity to climate externalities increase. We show that the impact of green investors primarily governs companies’ long-run emissions. Companies are further incentivized to reduce their emissions when green investors anticipate tighter climate regulations and climate-related technological innovations. However, heightened uncertainty regarding future climate risks alleviates green investors’ pressure on the cost of capital of companies and pushes them to increase their emissions. Calibrated on U.S. data, our model suggests that, albeit effective, the impact of green investors remains limited given their current wealth share and practices. This paper was accepted by George Serafeim, Special Section of Management Science on Business and Climate Change. Funding: This work was supported by the Europlace Institute of Finance. T. De Angelis received funding from the Engineering and Physical Sciences Research Council [Grant EP/R021201/1], and P. Tankov received funding from the Finance for Energy Markets research initiative of the Institut Europlace de Finance. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4472 .
QUAL HUMANISMO?
Authors: Mendes Ricardo , Marino Mario 
Published: June 2022

Em sua Nota sobre Maquiavel, Merleau-Ponty empreende uma leitura do filósofo florentino na busca do sentido de seu humanismo em contraposição a leituras que se atém apenas ao uso da força ou ao imoralismo de Maquiavel. Ao enfrentar as dificuldades do texto maquiaveliano, Merleau-Ponty abre uma via de interpretação segundo a qual o poder não é compreendido como mera força, mas sim como alteridade e assentimento, ou seja, relação mútua entre povo e príncipe, o que permite interpretar a obra de Maquiavel pelo ponto de vista da construção de uma vida coletiva, ou seja, um humanismo. Assim, retomamos o texto de Merleau-Ponty e a obra de Maquiavel, sobretudo O príncipe para compreender como esse diálogo entre os autores abre a perspectiva de um humanismo na obra do florentino.