bluuebunny/crossref_metadata_2025_split huggingface dataset:
The importance of well protected forests for the conservation genetics of West African colobine monkeys
Authors: Minhós Tânia , Borges Filipa , Parreira Bárbara , Oliveira Rúben , Aleixo‐Pais Isa , Leendertz Fabien H. , Wittig Roman , Fernandes Carlos Rodríguez , Marques Silva Guilherme Henrique Lima , Duarte Miguel , Bruford Michael W. , Ferreira da Silva Maria Joana , Chikhi Lounès 
Published: December 2022

AbstractIn tropical forests, anthropogenic activities are major drivers of the destruction and degradation of natural habitats, causing severe biodiversity loss. African colobine monkeys (Colobinae) are mainly folivore and strictly arboreal primates that require large forests to subsist, being among the most vulnerable of all nonhuman primates. The Western red colobusPiliocolobus badiusand the King colobusColobus polykomosinhabit highly fragmented West African forests, including the Cantanhez Forests National Park (CFNP) in Guinea‐Bissau. Both species are also found in the largest and best‐preserved West African forest—the Taï National Park (TNP) in Ivory Coast. Colobine monkeys are hunted for bushmeat in both protected areas, but these exhibit contrasting levels of forest fragmentation, thus offering an excellent opportunity to investigate the importance of well‐preserved forests for the maintenance of evolutionary potential in these arboreal primates. We estimated genetic diversity, population structure, and demographic history by using microsatellite loci and mitochondrial DNA. We then compared the genetic patterns of the colobines from TNP with the ones previously obtained for CFNP and found contrasting genetic patterns. Contrary to the colobines from CFNP that showed very low genetic diversity and a strong population decline, the populations in TNP still maintain high levels of genetic diversity and we found no clear signal of population decrease in Western red colobus and a limited decrease in King colobus. These results suggest larger and historically more stable populations in TNP compared to CFNP. We cannot exclude the possibility that the demographic effects resulting from the recent increase of bushmeat hunting are not yet detectable in TNP using genetic data. Nevertheless, the fact that the TNP colobus populations are highly genetically diverse and maintain large effective population sizes suggests that well‐preserved forests are crucial for the maintenance of populations, species, and probably for the evolutionary potential in colobines.
Associations among hypertension, dementia biomarkers, and cognition: The MEMENTO cohort
Authors: Lespinasse Jérémie , Chêne Geneviève , Mangin Jean‐Francois , Dubois Bruno , Blanc Frederic , Paquet Claire , Hanon Olivier , Planche Vincent , Gabelle Audrey , Ceccaldi Mathieu , Annweiler Cedric , Krolak‐Salmon Pierre , Godefroy Olivier , Wallon David , Sauvée Mathilde , Bergeret Sébastien , Chupin Marie , Proust‐Lima Cécile , Dufouil Carole ,   for the MEMENTO study group
Published: December 2022

AbstractIntroductionApproximately 40% of dementia cases could be delayed or prevented acting on modifiable risk factors including hypertension. However, the mechanisms underlying the hypertension–dementia association are still poorly understood.MethodsWe conducted a cross‐sectional analysis in 2048 patients from the MEMENTO cohort, a French multicenter clinic‐based study of outpatients with either isolated cognitive complaints or mild cognitive impairment. Exposure to hypertension was defined as a combination of high blood pressure (BP) status and antihypertensive treatment intake. Pathway associations were examined through structural equation modeling integrating extensive collection of neuroimaging biomarkers and clinical data.ResultsParticipants treated with high BP had significantly lower cognition compared to the others. This association was mediated by higher neurodegeneration and higher white matter hyperintensities load but not by Alzheimer's disease (AD) biomarkers.DiscussionThese results highlight the importance of controlling hypertension for prevention of cognitive decline and offer new insights on mechanisms underlying the hypertension–dementia association.Highlights
Paths of hypertension–cognition association were assessed by structural equation models.
The hypertension–cognition association is not mediated by Alzheimer's disease biomarkers.
The hypertension–cognition association is mediated by neurodegeneration and leukoaraiosis.
Lower cognition was limited to participants treated with uncontrolled blood pressure.
Blood pressure control could contribute to promote healthier brain aging.
Associations of phosphorylated tau pathology with whole‐hemisphere ex vivo morphometry in 7 tesla MRI
Authors: Sadaghiani Shokufeh , Trotman Winifred , Lim Sydney A. , Chung Eunice , Ittyerah Ranjit , Ravikumar Sadhana , Khandelwal Pulkit , Prabhakaran Karthik , Lavery Madigan L. , Ohm Daniel T. , Gabrielyan Marianna , Das Sandhitsu R. , Schuck Theresa , Capp Noah , Peterson Claire S. , Migdal Elyse , Artacho‐Pérula Emilio , Jiménez María del Mar Arroyo , Rabal Maria del Pilar Marcos , Sánchez Sandra Cebada , Prieto Carlos de la Rosa , Parada Marta Córcoles , Insausti Ricardo , Robinson John L. , McMillan Corey , Grossman Murray , Lee Edward B. , Detre John A. , Xie Sharon X. , Trojanowski John Q. , Tisdall M. Dylan , Wisse Laura E. M. , Irwin David J. , Wolk David A. , Yushkevich Paul A. 
Published: December 2022

AbstractIntroductionNeurodegenerative disorders are associated with different pathologies that often co‐occur but cannot be measured specifically with in vivo methods.MethodsThirty‐three brain hemispheres from donors with an Alzheimer's disease (AD) spectrum diagnosis underwent T2‐weighted magnetic resonance imaging (MRI). Gray matter thickness was paired with histopathology from the closest anatomic region in the contralateral hemisphere.ResultsPartial Spearman correlation of phosphorylated tau and cortical thickness with TAR DNA‐binding protein 43 (TDP‐43) and α‐synuclein scores, age, sex, and postmortem interval as covariates showed significant relationships in entorhinal and primary visual cortices, temporal pole, and insular and posterior cingulate gyri. Linear models including Braak stages, TDP‐43 and α‐synuclein scores, age, sex, and postmortem interval showed significant correlation between Braak stage and thickness in the parahippocampal gyrus, entorhinal cortex, and Broadman area 35.ConclusionWe demonstrated an association of measures of AD pathology with tissue loss in several AD regions despite a limited range of pathology in these cases.HighlightsNeurodegenerative disorders are associated with co‐occurring pathologies that cannot be measured specifically with in vivo methods.Identification of the topographic patterns of these pathologies in structural magnetic resonance imaging (MRI) may provide probabilistic biomarkers.We demonstrated the correlation of the specific patterns of tissue loss from ex vivo brain MRI with underlying pathologies detected in postmortem brain hemispheres in patients with Alzheimer's disease (AD) spectrum disorders.The results provide insight into the interpretation of in vivo structural MRI studies in patients with AD spectrum disorders.
Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia
Authors: Gonçalves Rafaella A. , Sudo Felipe K. , Lourenco Mychael V , Drummond Claudia , Assunção Naima , Vanderborght Bart , Ferreira Danielle D. P. , Ribeiro Felipe C. , Pamplona Fabricio A. , Tovar‐Moll Fernanda , Mattos Paulo , Ferreira Sergio T. , De Felice Fernanda G. 
Published: December 2022

AbstractIntroductionDepression is frequent among older adults and is a risk factor for dementia. Identifying molecular links between depression and dementia is necessary to shed light on shared disease mechanisms. Reduced brain‐derived neurotrophic factor (BDNF) and neuroinflammation are implicated in the pathophysiology of depression and dementia. The exercise‐induced hormone, irisin, increases BDNF and improves cognition in animal models of Alzheimer's disease. Lipoxin A4 is a lipid mediator with anti‐inflammatory activity. However, the roles of irisin and lipoxin A4 in depression remain to be determined.MethodsIn the present study, blood and CSF were collected from 61 elderly subjects, including individuals with and without cognitive impairment. Screening for symptoms of depression was performed using the 15‐item Geriatric Depression Scale (GDS‐15).ResultsCSF irisin and lipoxin A4 were positively correlated and reduced, along with a trend of BDNF reduction, in elderly individuals with depression, similar to previous observations in patients with dementia.DiscussionOur findings provide novel insight into shared molecular signatures connecting depression and dementia.
Ceria‐Supported Cobalt Catalyst for Low‐Temperature Methanation at Low Partial Pressures of CO2
Authors: Struijs Job J. C. , Muravev Valery , Verheijen Marcel A. , Hensen Emiel J. M. , Kosinov Nikolay 
Published: December 2022

AbstractThe direct catalytic conversion of atmospheric CO2 to valuable chemicals is a promising solution to avert negative consequences of rising CO2 concentration. However, heterogeneous catalysts efficient at low partial pressures of CO2 still need to be developed. Here, we explore Co/CeO2 as a catalyst for the methanation of diluted CO2 streams. This material displays an excellent performance at reaction temperatures as low as 175 °C and CO2 partial pressures as low as 0.4 mbar (the atmospheric CO2 concentration). To gain mechanistic understanding of this unusual activity, we employed in situ X‐ray photoelectron spectroscopy and operando infrared spectroscopy. The higher surface concentration and reactivity of formates and carbonyls—key reaction intermediates—explain the superior activity of Co/CeO2 as compared to a conventional Co/SiO2 catalyst. This work emphasizes the catalytic role of the cobalt‐ceria interface and will aid in developing more efficient CO2 hydrogenation catalysts.
Diantimony Complexes [CpR2Mo2(CO)4(μ,η2‐Sb2)] (CpR=C5H5, C5H4tBu) as Unexpected Ligands Stabilizing Silver(I)n (n=1–4) Monomers, Dimers and Chains
Authors: Shelyganov Pavel A. , Elsayed Moussa Mehdi , Seidl Michael , Scheer Manfred 
Published: December 2022

AbstractSynthesis and reactivity of transition metal compounds bearing “naked” pnictogen atoms is an active research area with remarkable bonding patterns observed in the formed compounds. Within this field, intense investigations on the coordination behavior of complexes possessing Pn and Asn (2≤n≤5) moieties have been conducted. However, studies on heavier analogues have been ignored so far due to arduous challenges related to low yields and moderate air stability. Herein, we present the first in‐depth study addressing the reactivity of organometallic complexes containing Sb‐donor atoms with several AgI salts. These reactions afforded twelve unprecedented aggregates as monomers, dimers as well as three‐ and four‐membered chains of AgI ions claimed in the literature to be inaccessible. Interatomic distances as well as computational evidence obtained with help of several different methods suggest the presence of Ag⋅⋅⋅Ag interactions in all complexes containing more than one AgI ion.
Cyanide Binding to [FeFe]‐Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway
Authors: Duan Jifu , Hemschemeier Anja , Burr David J. , Stripp Sven T. , Hofmann Eckhard , Happe Thomas 
Published: December 2022

AbstractHydrogenases are H2converting enzymes that harbor catalytic cofactors in which iron (Fe) ions are coordinated by biologically unusual carbon monoxide (CO) and cyanide (CN−) ligands. Extrinsic CO and CN−, however, inhibit hydrogenases. The mechanism by which CN−binds to [FeFe]‐hydrogenases is not known. Here, we obtained crystal structures of the CN−‐treated [FeFe]‐hydrogenase CpI fromClostridium pasteurianum. The high resolution of 1.39 Å allowed us to distinguish intrinsic CN−and CO ligands and to show that extrinsic CN−binds to the open coordination site of the cofactor where CO is known to bind. In contrast to other inhibitors, CN−treated crystals show conformational changes of conserved residues within the proton transfer pathway which could allow a direct proton transfer between E279 and S319. This configuration has been proposed to be vital for efficient proton transfer, but has never been observed structurally.
Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy
Authors: Corti Alessandro , Dominici Silvia , Piaggi Simona , Pompella Alfonso 
Published: December 2022

AbstractFerroptosis is a form of regulated cell death (RCD) characterized by intracellular iron ion accumulation and reactive oxygen species (ROS)‐induced lipid peroxidation. Ferroptosis in cancer and ferroptosis‐related anticancer drugs have recently gained interest in the field of cancer treatment. Boron is an essential trace element playing an important role in several biological processes. Recent studies have described contrasting effects of boric acid (BA) in cancer cells, ranging from protective/mitogenic to damaging/antiproliferative. Interestingly, boron has been shown to interfere with critical factors involved in ferroptosis—intracellular glutathione and lipid peroxidation in the first place. Thus, the present study was aimed to verify the ability of boron to modulate the ferroptotic process in HepG2 cells, a model of hepatocellular carcinoma. Our results indicate that—when used at high, pharmacological concentrations—BA can increase intracellular ROS, glutathione, and TBARS levels, and enhance ferroptosis induced by RSL3 and erastin. Also, high BA concentrations can directly induce ferroptosis, and such BA‐induced ferroptosis can add to the cytotoxic effects of anticancer drugs sorafenib, doxorubicin and cisplatin. These observations suggest that BA could be exploited as a chemo‐sensitizer agent in order to overcome cancer drug resistance in selected conditions. However, the possibility of reaching suitably high concentrations of BA in the tumor microenvironment will need to be further investigated.
De novo bio‐production of odd‐chain fatty acids in Saccharomyces cerevisiae through a synthetic pathway via 3‐hydroxypropionic acid
Authors: Qi Nailing , Ding Wentao , Dong Genlai , Wang Zhihui , Shi Shuobo 
Published: December 2022

AbstractOdd‐chain fatty acids (OCFAs) and their derivatives have attracted increasing attention due to their wide applications in the chemical, fuel, and pharmaceutical industry. However, most natural fatty acids are even‐chained, and OCFAs are rare. In this work, a novel pathway was designed and established for de novo synthesis of OCFAs via 3‐hydroxypropionic acid (3‐HP) as the intermediate in Saccharomyces cerevisiae. First, the OCFAs biosynthesis pathway from 3‐HP was confirmed, followed by an optimization of the precursor 3‐HP. After combining these strategies, a de novo production of OCFAs at 74.8 mg/L was achieved, and the percentage of OCFAs in total lipids reached 20.3%, reaching the highest ratio of de novo‐produced OCFAs. Of the OCFAs produced by the engineered strain, heptadecenoic acid (C17:1) and heptadecanoic acid (C17:0) accounted for 12.1% and 7.6% in total lipid content, respectively. This work provides a new and promising pathway for the de novo bio‐production of OCFAs.
AMP‐activated protein kinase is a key regulator of obesity‐associated factors
Authors: Mohseni Roohollah , Teimouri Maryam , Safaei Mohsen , Arab Sadeghabadi Zahra 
Published: December 2022

AbstractAn imbalance between caloric intake and energy expenditure leads to obesity. Obesity is an important risk factor for the development of several metabolic diseases including insulin resistance, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. So, controlling obesity could be effective in the improvement of obesity‐related diseases. Various factors are involved in obesity, such as AMP‐activated protein kinases (AMPK), silent information regulators, inflammatory mediators, oxidative stress parameters, gastrointestinal hormones, adipokines, angiopoietin‐like proteins, and microRNAs. These factors play an important role in obesity by controlling fat metabolism, energy homeostasis, food intake, and insulin sensitivity. AMPK is a heterotrimeric serine/threonine protein kinase known as a fuel‐sensing enzyme. The central role of AMPK in obesity makes it an attractive molecule to target obesity and related metabolic diseases. In this review, the critical role of AMPK in obesity and the interplay between AMPK and obesity‐associated factors were elaborated.
Withdrawn: MicroRNA‐214‐3p protects against myocardial ischemia–reperfusion injury by targeting demethylase lysine demethylase 3A
Authors: Wugeng Suya , Zan Shengju , Liu Yanmin , Bai Yuting , Hu Ailing , Wei Xiaojuan , Guo Cen , Su Xiaoling 
Published: December 2022

AbstractThe above article from Cell Biology International, published online on 5 December 2022, on Wiley Online Library (https://doi.org/10.1002/cbin.11920), has been withdrawn by agreement between the journal Editor in Chief, Sergio Schenkman, and John Wiley and Sons Ltd.The withdrawal has been agreed due to a technical error at the publisher that caused the article to be mistakenly published online.
Withdrawn: Ticagrelor reduces myocardial cell injury induced by myocardial ischemia/reperfusion in diabetic rats by activating JAK2/STAT3
Authors: Xie Daqi , Chen Qiwang , Huang Jie , Huang Changshun , Li Yijing , Li Shuiying , Zhang Sisi , Fang Huan , Sang Shang , Cao Yin 
Published: December 2022

The above article from Cell Biology International, published online on 5 December 2022, on Wiley Online Library (https://doi.org/10.1002/cbin.11940), has been withdrawn by agreement between the journal Editor in Chief, Sergio Schenkman, and John Wiley and Sons Ltd.The withdrawal has been agreed due to a technical error at the publisher that caused the article to be mistakenly published online although it had been rejected due to evidence that the peer review process for this paper was manipulated.
Impact of extrusion processing on the nutritional and physicochemical properties of intermediate wheatgrass (Thinopyrum intermedium)
Authors: Boakye Prince G. , Okyere Akua Y. , Annor George A. 
Published: December 2022

AbstractBackground and ObjectivesIntermediate wheatgrass (Thinopyrum intermedium, IWG) is a perennial grain crop being explored for mainstream food applications. The impact of extrusion on the nutritional and physicochemical characteristics of IWG was investigated for the first time. Extrudates were produced using a corotating twin‐screw extruder.FindingsExtrusion resulted in slight decreases in dietary fiber, fat, starch, and amylose contents of IWG, whereas protein and ash contents did not change. Significant increase in starch damage after extrusion led to significant increases in starch digestibility and hydration properties of IWG. Correspondingly, slowly digestible starches and resistant starches were significantly reduced after extrusion. Pasting profile studies showed significant decreases in all pasting parameters measured except for breakdown viscosity after extrusion. Higher antioxidant activity and phenolic acid levels, mainly due to ferulic acid, were observed even after extrusion. However, carotenoids content decreased significantly (up to 65.8% reduction in lutein and 50.4% reduction in zeaxanthin).ConclusionsThese findings show that extrusion cooking can improve the antioxidant activity and maintain high protein and dietary fiber levels in IWG, but it may not be suitable for preserving carotenoids in IWG.Significance and NoveltyExtrusion cooking could potentially be used to produce extruded snacks from IWG with high protein and dietary fiber.
Effects of extruded wheat bran on the physicochemical properties and edible quality of stewing noodles
Authors: Li Yibo , Yao Guoqin , Zhao Kemeng , Shen Wangyang , Wang Zhan , Fan Kai , Jia Xiwu 
Published: December 2022

AbstractBackground and objectivesAdding untreated wheat bran directly to the stewing noodles will result in a poor flavor and rough taste. This study aims to improve the palatability and flavor of wheat bran stewing noodles by using extrusion treatment. Effects of the extrusion treatment on the physicochemical properties and edible quality of wheat bran stewing noodles were analyzed.FindingsThe results showed that the total dietary fiber (TDF) content, insoluble dietary fiber (IDF) content and lipase activity of wheat bran decreased by 3.01%, 4.75%, and 71.49% after extrusion, respectively. In contrast, the soluble dietary fiber (SDF) content and the water holding capacity (WHC) of wheat bran increased by 64.60% and 32.08%, respectively (p < .05). The tensile strength of raw stewing noodles increased by 17.02% in the extruded wheat bran over that in the non‐extruded wheat bran group (p < .05), but the breaking distance showed no significant difference. Also, water distribution and migration times (T21, T22, T23) decreased significantly (p < .05) and the color (L*, a*, b*) increased significantly (p < .05) in stewing noodles after extruded wheat bran was added. Furthermore, starch granules were better encapsulated in the gluten network, visible pores decreased, and more compact network structure formed in the stewing noodles after extruded wheat bran was added. Regarding the qualities of cooked stewing noodles, the hardness, gumminess, and chewiness decreased and the amount of unpleasant volatile compounds, such as cyclohexanecarboxylic acid, acetic acid, and 2‐Methylpropanoic acid were reduced in the extruded wheat bran group, compared with the non‐extruded wheat bran group. Conversely, the amount of some of the pleasant volatile compounds, such as 2‐Butoxyethanol, (E)−2‐Hexenal and (E)−2‐octenal, increased in the extruded wheat bran group. Furthermore, added extruded wheat bran to the flour improved the smoothness, elasticity, color, and taste of stewing noodles, and closely approximated the chewiness and taste of the high‐gluten group.ConclusionsExtrusion treatment could improve the physicochemical properties and edible quality of bran‐fortified stewing noodles.Significance and noveltyThe wheat bran with extrusion is helpful for improving the physicochemical properties and edible quality of bran‐fortified stewing noodles. The results and discussion in this research may serve as reference for producers to guide quality improvement of stewing noodles enriched in wheat bran.
Water‐resistant organic thermoelectric generator with >10 μW output
Authors: Hata Shinichi , Maeshiro Kanto , Shiraishi Misaki , Yasuda Soichiro , Shiozaki Yuta , Kametani Koudai , Du Yukou , Shiraishi Yukihide , Toshima Naoki 
Published: December 2022

AbstractFlexible p–n thermoelectric generator (TEG) technology has rapidly advanced with power enhancement and size reduction. To achieve a stable power supply and highly efficient energy conversion, absolute chemical stability of n‐type materials is essential to ensuring large temperature differences between device terminals and ambient stability. With the aim of improving the long‐term stability of the n‐type operation of carbon nanotubes (CNTs) in air and water, this study uses cationic surfactants, such as octylene‐1,8‐bis(dimethyldodecylammonium bromide) (12–8–12), a gemini surfactant, to stabilize the nanotubes in a coating, which retains the n‐doped state for more than 28 days after exposure to air and water in experiments. TEGs with 10 p–n units of 12–8–12/CNT (n‐type) and sodium dodecylbenzene sulfonate/CNT (p‐type) layers are manufactured, and their water stability is evaluated. The initial maximum output of 16.1 µW (75 K temperature difference) is retained after water immersion for 40 days without using a sealant to prevent TEG module degradation. The excellent stability of these CNT‐based TEGs makes them suitable for underwater applications, such as battery‐free health monitoring and information gathering systems, and facilitates the development of soft electronics.