bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Design and implementation of network‐on‐chip router using multi‐priority based iterative round‐robin matching with slip
Authors: Singh Sangeeta , Ravindra J. V. R. , Naik B. Rajendra 
Published: April 2022

AbstractNowadays, network‐on‐chip (NoC) routers become important in several applications including mobile technology and digital communication. Multiple cores/processors are typically coupled using NoC routers, which considerably improve integrated circuit performance in terms of power, latency, throughput, and area. So, a novel 4 × 4 topology‐based NoC router using multi‐priority based iterative round‐robin matching with slip (MPiSLIP) routing algorithm is implemented in this work. The proposed work contains different operational blocks classification such as route computation using static straight allocator, route controlling using MPiSLIP arbiter, a crossbar switch, combined parallel virtual channel and switch allocation unit, look ahead bypass route computation (LBRC), and input‐output ports. The MPiSLIP routing mechanism also determines the priorities necessary for route development. Finally, by bypassing the switches and fulfilling all of the priories in a look‐ahead manner, LBRC is employed to establish the effective path between input ports and output ports. The simulation results show that the proposed MPiSLIP‐based NoC routing method resulted in a reduced area, power, and latency as compared to the open‐source NoCs, multi‐processor NoCs, multi‐core NoCs, and conventional routing algorithms.
What’s in a Fish Species Name and When to Change It?
Authors: Tracy Bryn H 
Published: April 2022

Abstract
Honorific scientific names have recently received intense scrutiny because societal values have changed. Across disciplines groundswells of support for renaming species have occurred; specifically those named after dishonorable people or with culturally inappropriate common names. Fishes have not been immune to this attention, but changes have come slowly. Now is the time for AFS to confront this controversial topic. The renaming processes can be aided by examining what other organizations have done. First, AFS should develop procedures for renaming species epithets and common names for species named after people who advocated racist and/or sexist views, used derogatory names in their writings, or did reprehensible things. Second, this process should include input from fisheries professionals who have to work with these names within the context of fisheries management, the AFS Diversity, Equity, and Inclusion Committee, and Indigenous peoples. Third, ichthyologists should change how their newly described species are named. As descriptions are written, an opportunity presents itself to name species with names of Indigenous peoples or after people that more closely represent the value sets of our society and profession. North Carolina, with its specious freshwater fish fauna, can serve as an illustrative case study of controversial fish names that warrant this discussion.
Physicochemical characteristics and immunoregulatory activities of polysaccharides from five cultivars of Chrysanthemi Flos
Authors: Wang Ying , Chen Xuetao , Zhao Ping , Ren Lu , Li Xia , Gao Wenyuan 
Published: April 2022

AbstractThis study compared the physicochemical characteristics and immunomodulatory activities of chrysanthemums’ polysaccharides (JPs) from five cultivars. Significant differences were found in the molecular weights, the ratios of monosaccharide compositions, and morphological properties. Polysaccharides of Gongju (GJP) had the lowest molecular weight populations and polysaccharides of Boju (BJP) had the highest. SEM showed that GJP and polysaccharides of Qiju had looser and uniform surface structures, which are beneficial for being developed into instant products. Immunoregulatory assay revealed that JPs enhanced the phagocytosis and proliferation of RAW264.7 cells without obvious cytotoxicity, and upregulated the release level of TNF‐α, IFN‐γ, and NO. Immune‐enhancing activity correlated with their molecular weights, the contents of glucuronic acid and arabinose, and microstructure, which performed differently according to different cultivars. The results suggested that BJP and polysaccharides of Hangbaiju are more suitable to be developed as new functional foods for enhancing immunity, and provided a reference for selection based on the immunization requirements.
Petrogenesis of Miocene igneous rocks in the Tafresh area (central Urumieh‐Dokhtar magmatic arc, Iran): Insights into mantle sources and geodynamic processes
Authors: Babazadeh Shahrouz , Raeisi Davood , D'Antonio Massimo , Zhao Miao , Long Leon E. , Cottle John M. , Modabberi Soroush 
Published: April 2022

Cenozoic tectono‐magmatism in Iran is widely considered to be related to subduction of the Neo‐Tethys Ocean. We employed whole‐rock and mineral geochemistry and isotopic data of intrusive rocks from Tafresh, central Urumieh‐Dokhtar magmatic arc, to evaluate the role of the mantle in magmatism, to assess the timing of emplacement, and to interpret the tectonic setting. Rock compositions range from gabbro or gabbro‐diorite (plagioclase + pyroxene ± olivine), to diorite (plagioclase + amphibole ± pyroxene), to granodiorite (quartz + plagioclase + K‐feldspar + amphibole + biotite), exhibiting high‐alumina calc‐alkaline affinity. Major oxide and trace element variations vary systematically from less to more evolved rocks suggesting a major role for fractional crystallization processes. Zircon LA‐ICP‐MS U–Pb ages of major rock types are in the range of 24–19 Ma, whereas those of gabbroic dikes are ~17.5 Ma. ԐNd values range between −1.8 and 3.7, and (87Sr/86Sr)i is narrowly restricted to 0.705–0.706, suggesting a common mantle source. The enrichment in light rare earth element (REE) enrichment and flat heavy REE patterns couple depletion of Nb–Ta–Ti indicate that subducting oceanic crust had interacted with the overlying mantle wedge. High‐alumina, mid‐Mg# Tafresh plutonic rocks formed from hydrous melts from which Ca‐pyroxene and magnetite crystallized earlier than plagioclase, whereas late‐crystallizing zircon nucleated while magma traversed through lithospheric mantle and Cadomian crust. Modelling of isotope and incompatible‐element patterns suggests the contribution of no more than ~5% molten sediment or other crustal components in Tafresh magma, at a developmental stage before most plagioclase and amphibole had crystallized. The Miocene Tafresh plutons originated during the final stages of subduction, before the collision between the Arabian and Eurasian plates.
Astrocyte regulation of neural circuit activity and network states
Authors: Oliveira João Filipe , Araque Alfonso 
Published: April 2022

AbstractAstrocytes are known to influence neuronal activity through different mechanisms, including the homeostatic control of extracellular levels of ions and neurotransmitters and the exchange of signaling molecules that regulate synaptic formation, structure, and function. While a great effort done in the past has defined many molecular mechanisms and cellular processes involved in astrocyte‐neuron interactions at the cellular level, the consequences of these interactions at the network level in vivo have only relatively recently been identified. This review describes and discusses recent findings on the regulatory effects of astrocytes on the activity of neuronal networks in vivo. Accumulating but still limited, evidence indicates that astrocytes regulate neuronal network rhythmic activity and synchronization as well as brain states. These studies demonstrate a critical contribution of astrocytes to brain activity and are paving the way for a more thorough understanding of the cellular bases of brain function.
Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort
Authors: Subramaniapillai Sivaniya , Suri Sana , Barth Claudia , Maximov Ivan I. , Voldsbekk Irene , van der Meer Dennis , Gurholt Tiril P. , Beck Dani , Draganski Bogdan , Andreassen Ole A. , Ebmeier Klaus P. , Westlye Lars T. , de Lange Ann‐Marie G. 
Published: April 2022

AbstractCardiometabolic risk (CMR) factors are associated with accelerated brain aging and increased risk for sex‐dimorphic illnesses such as Alzheimer's disease (AD). Yet, it is unknown how CMRs interact with sex and apolipoprotein E‐ϵ4 (APOE4), a known genetic risk factor for AD, to influence brain age across different life stages. Using age prediction based on multi‐shell diffusion‐weighted imaging data in 21,308 UK Biobank participants, we investigated whether associations between white matter Brain Age Gap (BAG) and body mass index (BMI), waist‐to‐hip ratio (WHR), body fat percentage (BF%), and APOE4 status varied (i) between males and females, (ii) according to age at menopause in females, and (iii) across different age groups in males and females. We report sex differences in associations between BAG and all three CMRs, with stronger positive associations among males compared to females. Independent of APOE4 status, higher BAG (older brain age relative to chronological age) was associated with greater BMI, WHR, and BF% in males, whereas in females, higher BAG was associated with greater WHR, but not BMI and BF%. These divergent associations were most prominent within the oldest group of females (66–81 years), where greater BF% was linked to lower BAG. Earlier menopause transition was associated with higher BAG, but no interactions were found with CMRs. In conclusion, the findings point to sex‐ and age‐specific associations between CMRs and brain age. Incorporating sex as a factor of interest in studies addressing CMR may promote sex‐specific precision medicine, consequently improving health care for both males and females.
Hospital‐physician integration and risk‐coding intensity
Authors: Post Brady , Norton Edward C. , Hollenbeck Brent K. , Ryan Andrew M. 
Published: April 2022

AbstractHospital‐physician integration has surged in recent years. Integration may allow hospitals to share resources and management practices with their integrated physicians that increase the reported diagnostic severity of their patients. Greater diagnostic severity will increase practices' payment under risk‐based arrangements. We offer the first analysis of whether hospital‐physician integration affects providers' coding of patient severity. Using a two‐way fixed effects model, an event study, and a stacked difference‐in‐differences analysis of 5 million patient‐year observations from 2010 to 2015, we find that the integration of a patient's primary care doctor is associated with a robust 2%–4% increase in coded severity, the risk‐score equivalent of aging a physician's patients by 4–8 months. This effect was not driven by physicians treating different patients nor by physicians seeing patients more often. Our evidence is consistent with the hypothesis that hospitals share organizational resources with acquired physician practices to increase the measured clinical severity of patients. Increases in the intensity of coding will improve vertically‐integrated practices' performance in alternative payment models and pay‐for‐performance programs while raising overall health care spending.
Identification of the regulatory role of the circ_0004788/miR‐515‐5p/FGF2 network in nasopharyngeal carcinoma development
Authors: Li Dajun , Li Xianzhe , Fan Gai , Bian Guiqin 
Published: April 2022

AbstractBackgroundCircularRNAs (circRNAs) played vital roles in nasopharyngeal carcinoma (NPC). However, the impacts of circ_0004788 on the development of NPC have not been explored.MethodsCell counting kit‐8 (CCK‐8), 5‐Ethynyl‐2′‐deoxyuridine (EdU) and colony formation assays were applied to determine cell proliferation. Wound healing, transwell invasion assay, tube formation assay, and flow cytometry were employed for the detection of cell migration, invasion, angiogenesis, and apoptosis, respectively. Xenograft tumor experiment was used to explore the biological role of circ_0004788 in NPC in vivo.ResultsCirc_0004788 and fibroblast growth factor 2 (FGF2) were significantly elevated, and microRNA‐515‐5p (miR‐515‐5p) was dramatically decreased in NPC tissues and cells. The impacts of circ_0004788 knockdown on cell progression in NPC cells were reversed by miR‐515‐5p inhibitor, and FGF2 overexpression could block the suppressive effect of miR‐515‐5p on cell progression in NPC cells.ConclusionCirc_0004788 knockdown restrained the progression of NPC via the miR‐515‐5p/FGF2 axis.
Clustering assisted artificial neural network for handling noisy big data: An application for estimation of parameter in combined mode conduction and radiation heat transfer
Authors: Mishra Vijay K. , Anand Kshitij , Bhardwaj Abhishek 
Published: April 2022

AbstractA pattern net assisted mapping artificial neural network (PAMANN) model for estimation of parameters in problem with large data (1300 × 121 matrix size) is reported. A pattern net‐based multilayer perceptron neural network (MLPNN) model for clustering the data, followed by mapping MLPNN model for mapping the target with the input, is developed as PAMANN model. A heat transfer problem with combined mode conduction and radiation in porous medium is solved numerically, and is called direct model. In the inverse model, a PAMANN model is developed by using data generated through the direct model. The PAMANN model is able to estimate two parameters (extinction coefficient β and convective coupling P2) after taking temperature profile as input. The model is tested for different number of neurons in hidden layer, and different levels of noise in input data. Twelve different algorithms are explored in training of mapping MLPNN, and compared for performance. Levenberg–Marquardt algorithm is found to estimate the parameters with high accuracy, but took high CPU time. Bayesian regularization is found to consume very high CPU time with moderate accuracy in estimation of parameters. Variations in hidden layer neuron number and noise in input data, were done to analyze the performance of mapping MLPNN with different training algorithms. Algorithms O‐Step Secant, conjugate gradient with Polak‐Ribiére updates, and conjugate gradient with Fletcher‐Reeves updates are able to handle all variations of noise and number of neurons in hidden layer, with good accuracy of estimation and low CPU time consumption. Under high computational resource LM algorithm can be used for all cases. Up to 0.99132 value of regression coefficient is obtained in mapping MLPNN model with 15 hidden neurons, indicating the high accuracy of the model. With the help of PAMANN model, highly accurate (absolute error 1.78%) estimation of parameters is obtained. The model can handle upto 1% noise in input data, while giving accurate results.
Flow due to a porous stretching/shrinking sheet with thermal radiation and mass transpiration
Authors: Mahabaleshwar Ulavathi Shettar , Sneha Kolkar Nanjappa , Souayeh Basma 
Published: April 2022

AbstractThis study investigates the behavior of carbon nanotubes (CNT) approaching an unsteady flow of a Newtonian fluid over a stagnation point on a stretching surface employing porous media. It flows when the liquid begins to move with the progression of time. Heat exchange with the environment has an impact on the flow. The implicitly limited component technique is used to solve the nondimensional partial differential equation with an associated boundary layer, which is an unstable system. Analytically, the solutions, as well as the required boundary conditions, are obtained. The effects of mass transpiration, volume fraction, and heat radiation on Newtonian fluid flow through porous media are explored. Single‐ and multi‐walled CNTs are used as well as water, as base fluids in the experiment. The impact of thermal radiation and heat source/sink is shown in the energy equation, which is solved under four different cases: uniform heat flux case, constant wall temperature case, general power‐law wall heat flux case, and general power‐law wall temperature case. By supplying distinct physical characteristics, a theoretical analysis of the existence and nonexistence of unique and dual solutions may be explored. These physical parameters determine the velocity distribution and temperature distribution. Prescribed surface temperature (PST) and prescribed wall heat flux (PHF) heat transfer solutions can be written using confluent hypergeometric equations, and generic power‐law PST and PHF situations can also be expressed using confluent hypergeometric equations. The graphical representations assist in the discussion of the current study's findings.
Design and simulation of water‐cooled dehumidifier for HDH desalination plant
Authors: Shaik Vajeer Baba , Tangellapalli Srinivas 
Published: April 2022

AbstractCondensers are widely used in thermal applications to transfer the maximum heat between the working fluids and change the phase of vapor. In basic thermal‐based humidification–dehumidification (HDH) desalination, a condenser is used as a water‐cooled dehumidifier for improving freshwater production within the minimum area. In this thermal‐based HDH system, desalinated water production is the major output. The simulation tool is used to analyze the thermohydraulic performance of a water‐cooled dehumidifier. In this thermohydraulic analysis, variables, like, airflow rate, tube diameter, and longitudinal pitch are thoroughly investigated to identify the optimum parameters for improving the performance of the water‐cooled dehumidifier. The obtained results indicate that the heat transfer area and performance index are increased when the airflow rate and tube diameter change. But at 8 and 10 mm tube diameter, the surface area and performance index are contradictory in nature while longitudinal pitch varies from 30 to 45 mm. At 12.5 mm tube diameter, surface area and performance index decrease gradually but the certain period of pitch limit performance increases markedly. In addition, the yield of HDH desalination has been investigated. When the mass flow rate changed from 100 to 500 kg/h, it was 0.667–3.32 L/h.
Adapting open science and pre‐registration to longitudinal research
Authors: Petersen Isaac T. , Apfelbaum Keith S. , McMurray Bob 
Published: April 2022

AbstractOpen science practices, such as pre‐registration and data sharing, increase transparency and may improve the replicability of developmental science. However, developmental science has lagged behind other fields in implementing open science practices. This lag may arise from unique challenges and considerations of longitudinal research. In this paper, preliminary guidelines are provided for adapting open science practices to longitudinal research to facilitate researchers' use of these practices. The guidelines propose a serial and modular approach to registration that includes an initial pre‐registration of the methods and focal hypotheses of the longitudinal study, along with subsequent pre‐ or co‐registered questions, hypotheses, and analysis plans associated with specific papers. Researchers are encouraged to share their research materials and relevant data with associated papers and to report sufficient information for replicability. In addition, there should be careful consideration of requirements regarding the timing of data sharing, to avoid disincentivizing longitudinal research.
The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma
Authors: Liao Wenwei , Du Jinpeng , Wang Zhen , Feng Qingbo , Liao Mingheng , Liu Huixian , Yuan Kefei , Zeng Yong 
Published: April 2022

AbstractHepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Metabolic reprogramming is considered to be an important hallmark of cancer. Emerging studies have demonstrated that noncoding RNAs (ncRNAs) are closely associated with metabolic reprogramming of HCC. NcRNAs can directly regulate the expressions or functions of metabolic enzymes or indirectly regulate the metabolism of HCC cells through some vital signaling pathways. Until now, the mechanisms of HCC development and progression remain largely unclear, and understanding the regulatory mechanism of ncRNAs on metabolic reprogramming of HCC may provide an important basis for breakthrough progress in the treatment of HCC. In this review, we summarize the ncRNAs involved in regulating metabolic reprogramming of HCC. Specifically, the regulatory roles of ncRNAs in glucose, lipid and amino acid metabolism are elaborated. In addition, we discuss the molecular mechanism of ncRNAs in regulation of metabolic reprogramming and possible therapeutic strategies that target the metabolism of cancer cells by modulating the expressions of specific ncRNAs.
Triage performance and predictive value of the human gene methylation panel among women positive on self‐collected HPV test: Results from a prospective cohort study
Authors: Zhang Li , Zhao Xuelian , Hu Shangying , Chen Shimin , Zhao Shuang , Dong Li , Carvalho André L. , Muwonge Richard , Zhao Fanghui , Basu Partha 
Published: April 2022

AbstractTriaging of women positive for high‐risk human papillomavirus (hrHPV) on self‐collected samples requires a molecular reflex test to avoid recall for cytology or visual tests. We assessed triage performance and predictive value of human gene methylation panel (ZNF671/ASTN1/ITGA4/RXFP3/SOX17/DLX1) alone and with combination of HPV16/18 genotyping in a longitudinal screening study. Out of 9526 women at baseline, 1758 women positive for hrHPV on self‐collected samples followed up yearly were included in the current analysis. Satisfactory risk stratification to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was demonstrated by the methylation panel with an odds ratio (OR) of 11.3 among methylation‐positive women compared to methylation‐negative counterparts. Triaging with methylation panel reduced colposcopy referral rate by 67.2% with sensitivity and specificity of 83.0% and 69.9% to detect CIN2+. The corresponding values for the combining methylation and HPV 16/18 were 96.6% and 58.3%. The cumulative 3‐year incident CIN2+ risk was 6.8% (95% CI: 4.9%‐8.6%) for hrHPV positive women, which was reduced to 4.5% (95% CI: 2.7%‐6.3%) and 2.9% (95% CI: 1.2%‐4.5%) for women negative on methylation triaging alone and negative on the combined strategy. The corresponding risk for women positive for both methylation and HPV 16/18 reached 33.7% (95% CI: 19.0%‐45.8%). Our study demonstrated the satisfactory triage performance and predictive value of the methylation panel, especially in combination with HPV 16/18 genotyping. The substantially lower risk of CIN2+ among the triage negative women over the next 3 years suggests that the interval for repeat HPV test can be safely extended to at least 2 years.