bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow Characteristics and Heat Transfer Enhancement of Sinusoidal Corrugated Channels with Different Configurations
Authors: ÖZBOLAT Veli , ŞAHİN Beşir 
Published: March 2022

This study investigated flow characteristics and heat transfer enhancement in various sinusoidal corrugated channels. The channel height and the phase shift effects on the flow structures and thermal performances were examined numerically for Reynolds numbers in the range of 2500≤Re≤7500. The geometrical configurations of this study cover three different channel heights (Hmin/Hmax=0.36, 0.54, 0.72) and three phase shift angles (φ=0°, 90°, 180°). Velocity distribution, turbulence intensity, local and averaged Nusselt numbers, and friction factor were calculated for various configurations. Finally, thermal performance factors (TPF) were also calculated to determine the optimum channel configuration and
operating condition.
Study on immobilization of nitrogen and phosphorus in sediments using modified fly ash composite material
Authors: Zou Jiale , Sun Rongqiang , Zhu Zhaoliang , Zhou Hao , Ji Xinyu 
Published: March 2022

Abstract
In this paper, a new type of particle-modified fly ash composite material was prepared using fly ash as the main raw material, which could immobilize nitrogen and phosphorus pollutants in sediment and control its release into water. Preliminary modification of fly ash was achieved by soaking in NaOH and calcining at high temperature of CaO. The modified fly ash was mixed with four auxiliary materials, namely cement, slag, water glass and quartz sand, and was formed after 14 days of curing. X-ray diffraction (XRD) and scanning electron microscope-energy dispersive spectrometer (SEM-EDS) were used to examine the material microstructure, element composition, crystal mineral changes, and also to further examine the physical indicators and mechanical properties of the material. In the end, we chose to use modified fly ash composite 10% cement to make granular modified fly ash composite materials. Taking the actual polluted river sediment as the research object, a 22-day coverage effect experiment was carried out, and it was finally found that the 2 cm-thick modified fly ash composite material cover layer inhibited the ammonia nitrogen (NH4+-N)、total nitrogen (TN) and total phosphorus (TP) of the sediments at 90.91%, 75.06% and 90.63%, respectively. This confirms that it is a material with good performance and practical application value.
Ivabradine in the Management of COVID-19-related Cardiovascular Complications:
A Perspective
Authors: Baka Tomas , Repova Kristina , Luptak Ivan , Simko Fedor 
Published: March 2022

Abstract:
Besides acute respiratory distress syndrome, acute cardiac injury is a major complication in severe
coronavirus disease 2019 (COVID-19) and is associated with a poor clinical outcome. Acute cardiac injury with
COVID-19 can be of various etiologies, including myocardial ischemia or infarction and myocarditis, and may
compromise cardiac function, resulting in acute heart failure or cardiogenic shock. Systemic inflammatory
response increases heart rate (HR), which disrupts the myocardial oxygen supply/demand balance and worsens
cardiac energy efficiency, thus further deteriorating the cardiac performance of the injured myocardium. In fact,
the combination of elevated resting HR and markers of inflammation synergistically predicts adverse cardiovascular
prognosis. Thus, targeted HR reduction may potentially be of benefit in cardiovascular pathologies
associated with COVID-19. Ivabradine is a drug that selectively reduces HR via If current inhibition in the sinoatrial
node without a negative effect on inotropy. Besides selective HR reduction, ivabradine was found to exert
various beneficial pleiotropic effects, either HR-dependent or HR-independent, including anti-inflammatory,
anti-atherosclerotic, anti-oxidant and antiproliferative actions and the attenuation of endothelial dysfunction and
neurohumoral activation. Cardioprotection by ivabradine has already been indicated in cardiovascular pathologies
that are prevalent with COVID-19, including myocarditis, acute coronary syndrome, cardiogenic shock or
cardiac dysautonomia. Here, we suggest that ivabradine may be beneficial in the management of COVID-19-
related cardiovascular complications.
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s
Disease: An Overview
Authors: Prasanna Chandu Anantha Lakshmi , Sharma Abha 
Published: March 2022

Abstract:
Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disorder that may account for approximately 60-70% of cases of dementia worldwide. AD is characterized by im-paired behavioural and cognitive functions, including memory, language, conception, attentiveness, judgment, and reasoning problems. The two important hallmarks of AD are the appearance of plaques and tangles of amyloid-beta (Aβ) and tau proteins, respectively, in the brain based on the etiology of the disease, including cholinergic impairment, metal dyshomeostasis, oxidative stress, and degrada-tion of neurotransmitters. Currently, the used medication only provides alleviation of symptoms but is not effective in curing the disease, which creates the need to develop new molecules to treat AD. Heterocyclic compounds have proven their ability to be developed as drugs for the treatment of vari-ous diseases. The five-membered heterocyclic compound triazole has received foremost fascination for the discovery of new drugs due to the possibility of structural variation. Moreover, it has proved its significance in various drug categories. This review mainly summarizes the recent advancements in the development of novel 1,2,3-triazole and 1,2,4-triazole-based molecules in the drug discovery process for targeting various AD targets such as phosphodiesterase 1 (PDE1) inhibitors, apoptosis signal-regulating kinase 1 (ASK1) inhibitors, somatostatin receptor subtype-4 (SSTR4) agonist, sev-eral other druggable targets, molecular modelling studies, as well as various methodologies for the synthesis of triazoles containing molecules such as click reaction, Pellizzari reaction, and Einhorn-Brunner reaction.
Profile of Gut Microbiota of Adults with Diabetes Mellitus Type 1: A
Systematic Review
Authors: Moreira Larissa Almenara Abreu , da Paz Lima Larissa , de Oliveira Falcão Maíra Aparecida , Rosado Eliane Lopes 
Published: March 2022

Background:
Type 1 diabetes mellitus (T1DM) is a chronic disease of clinical importance,
whose prevalence has increased in Brazil and worldwide. Among the possible factors involved
in the genesis and control of the disease, the intestinal microbiota (IM) deserves to be highlighted,
but studies that report differences between the IM of patients with T1DM and those who
are healthy are still contradictory and scarce.

Objective:
The objective of this paper was to evaluate the IM profile of T1DM and healthy patients,
in order to verify possible differences and to evaluate the possibility of the influence of IM
on glycemic control in T1DM.

Methods:
Of the 2716 articles found, nine were included in this review, and all of which were randomized,
observational, cross-sectional, cohort and case-control studies that characterized the
composition of IM in adults with T1DM and healthy adults.

Results:
Studies are very diverse, which makes it difficult to associate the IM profile with T1DM
etiology and control, however it was found that there was a prevalence of the phylum Firmicutes in
the IM of individuals with T1DM and that there was no significant difference in the relative abundance
of Bacteroidetes in both populations.

Conclusion:
It was also possible to identify an inverse relationship of the genus Bifidobacterium
and a positive relationship of the genera Bacteroidetes and Prevotella with the concentration
ofglycated hemoglobin. More studies are needed to contemplate the characterization of IM in
healthy and T1DM individuals.
Low-Cost Technologies that can be Integrated into Medical Education in
Emerging Areas
Authors: Țoța Paul , Vaida Mircea-Florin 
Published: March 2022

Background:
The situation created by global emergencies, such as the current global pandemic
[1], has led in many parts of the world to the cessation of clinical practice in hospitals for medical
and nursing students, although in medical education the contact with the patient and the practical
practice of various medical techniques and procedures by contact is necessary. However, in situations
of biological risk, it is natural to avoid any possibility of exposure for students.

Material and Methods:
The objective of this paper is to analyze the possibility of creating low cost,
modular telepresence robots, adapted for medical clinical practice and capable of allowing practicing
students to interact remotely with patients, communicate with them, monitor them, help them move,
and also to be able to measure parameters such as temperature using thermal vision, pulse measurement
or, the ability of the limbs to move. The robot consists of a mobile stretcher, with the possibility
of moving both with wheels and with the help of legs, which allows the patient to move without human
assistance in areas with obstacles. The method of achieving this goal refers to the realization of several
modular applications and each to solve specific tasks, and finally to be interconnected in a telepresence
robot that makes possible the remote interaction of practicing students with patients.

Results:
The research results emerge both from the prototypes made and from the simulations and the
results of measuring certain vital parameters sent by the telepresence robot via the internet to the medical
team.

Conclusion:
The idea of modular integration of several individual applications is feasible and offers
the advantage of easily adapting to patients with various ailments and medical needs.
Transition resistance influence of the upper structure track ballast on the rail-to-earth potential at AC railway sections
Authors: Krylov A. A. , Rebrov I. A. , Rudashevskaya A. V. , Rudashevskiy R. A. , Khar'kovskaya E. D. 
Published: March 2022

Introduction. The purpose of the research is to evaluate transition resistance modifications of the upper structure track in passing from the ballast to the ballastless track. These modifications effect the rail-to-earth potential difference. Moreover, they refer to the reverse traction system, to the reverse traction current of railway automation devices and to the required level of electrical safety guarantee.Materials and methods. The authors used both the analytical method of the rail-to-earth potential testing and the practical one based on experimental studies of the rail track transition resistance measurements. The authors carried out experiments on the Rozengartovka — Boitsovo — Bikin section of the Far Eastern Railway. This section includes the heavy freight traffic with the increased electric resistance of the track ballast by the upper structure redevelopment.Results. The research defines the main criteria of the rail-to-earth potential considering the 2×25 and 25 kV reverse traction of monophase AC systems with the 50 Hz frequency and depending on the experimental area location in terms of traction substations, on the climate and geological factors and on the freight traffic density.Discussion and conclusion. The obtained results will improve the accuracy of the rail-to-earth potential difference considering not only indicated factors, but also the upper structure type, track features and a feed line scheme for contact wire.
Perception of the Food and Drug Administration Electronic Cigarette Flavor Enforcement Policy on Twitter: Observational Study
Authors: Lu Xinyi , Sun Li , Xie Zidian , Li Dongmei 
Published: March 2022

BackgroundOn January 2, 2020, the US Food and Drug Administration (FDA) released the electronic cigarette (e-cigarette) flavor enforcement policy to prohibit the sale of all flavored cartridge–based e-cigarettes, except for menthol and tobacco flavors.ObjectiveThis research aimed to examine the public perception of this FDA flavor enforcement policy and its impact on the public perception of e-cigarettes on Twitter.MethodsA total of 2,341,660 e-cigarette–related tweets and 190,490 FDA flavor enforcement policy–related tweets in the United States were collected from Twitter before (between June 13 and August 22, 2019) and after (between January 2 and March 30, 2020) the announcement of the FDA flavor enforcement policy. Sentiment analysis was conducted to detect the changes in the public perceptions of the policy and e-cigarettes on Twitter. Topic modeling was used for finding frequently discussed topics about e-cigarettes.ResultsThe proportion of negative sentiment tweets about e-cigarettes significantly increased after the announcement of the FDA flavor enforcement policy compared with before the announcement of the policy. In contrast, the overall sentiment toward the FDA flavor enforcement policy became less negative. The FDA flavor enforcement policy was the most popular topic associated with e-cigarettes after the announcement of the FDA flavor enforcement policy. Twitter users who discussed about e-cigarettes started to talk about other alternative ways of getting e-cigarettes after the FDA flavor enforcement policy.ConclusionsTwitter users’ perceptions of e-cigarettes became more negative after the announcement of the FDA flavor enforcement policy.
Law Enforcement Against Online Prostitution Providers In Indonesia And Egypt
Authors: Yuspin Wardah , Allah Aya Mohammed Youssef Abd , Wardiono Kelik , Maulani Indah 
Published: March 2022

Purpose of the study :Describe the comparison of Online Prostitution Law in Indonesia and Egypt Methodology :Research methodology is qualilative approach with normative legal research. Therefore, in this study, it is preferable to secondary data collected by literature studies. Data that has been processed for further qualitative analysis Results:The results of this study found that the comparison of the two countries has similarities, namely the lack of legislation on online prostitution and the existence of a police specialty that investigates cases of prostitution in Egypt namely "Good Moral Police" while in Indonesia there is such police available. Novelty/ Originality of this study:The novelty value of this study is the comparison of the law with the specificity of the police who are in the case of prostitution in Egypt.
Methodological Assessment of Weaknesses in Systematic Reviews on Pulp Capping
Authors: Tsompani Genovefa , Anastasopoulos Menelaos 
Published: March 2022

Introduction: Clinical decision making in dentistry is directly impacted by the systematic reviews available. The increasing number of systematic reviews along with their direct impact in clinical practice has emerged a need to assess their quality. Pulp capping is an important alternative to the more invasive interventions such as endodontic treatment and aims to preserve pulp tissue. The aim of this study is to methodologically assess the weaknesses of systematic reviews on pulp capping and provide recommendations on how to improve them.
Methods: An electronic literature search was conducted in Pubmed, Cochrane Library and Web of Science up to January 2022. Systematic reviews with or without meta-analysis including randomized and non-randomized studies on pulp capping were retrieved. A methodological assessment of their quality was performed using AMSTAR 2.
Results: A total of 203 publications were identified and reviewed for eligibility. Twenty-seven fulfilled the inclusion criteria. The reviews were assessed using AMSTAR 2 by two independent reviewers. The results were analyzed, and weaknesses were noted.
Conclusion: The study suggests an inconsistency in methods and structure in systematic reviews on pulp capping. Readers of the reviews should make use of AMSTAR 2 in order to evaluate their quality. Suggestions and weaknesses pinpointed can aid future systematic reviews to be more comprehensive with a more unified methodology.
Dynamics of seasonal changes in introduced plants in Eastern Transbaikalia
Authors: Banshchikova Ekaterina A. 
Published: March 2022

The article presents a comparative analysis of the seasonal development of introduced plants in the weather conditions of Eastern Transbaikalia for the growing periods from 2014 to 2019. The results presented are taken from 6-year phenological observations conducted in the arboretum of the Institute of Natural Resources, Ecology and Cryology SB RAS. We constructed the phenological spectra of the studied objects by year. We studied the main phenological indicators of vegetation the East Asian forest-steppe and Manchurian-Daurian preboreal species. We analyzed the meteorological data: the mean daily air temperatures and precipitation for the months of the growing season (2014–2019), and the sum of active temperatures and precipitation for this period. The data on the dynamics of the development of shrubby plant species in conditions of Eastern Transbaikalia for 2014–2019 indicate that plants respond adaptively to changes in weather conditions. Hereditary and physiological characteristics showed that the introduced plants are characterized as cold-resistant and drought-resistant. Corylus heterophylla and Armeniaca sibirica are most sensitive to temperature extremes in spring, in contrast to Euonymus maackii, which were stable. Low above-zero air temperatures in spring and a large amount of precipitation encourage plants to pass the development stages (phenophases) faster than in dry and warm weather (Corylus heterophylla, Armeniaca sibirica). At the same time, low temperatures (frosts) in spring with a wet period at the time of flowering negatively affect the further fruit formation in Corylus heterophylla individuals. Rainy or cloudy days reduce the color intensity of the autumn leaves, and cool, dry, and sunny weather contributes to the autumn color scheme. Armeniaca sibirica and Corylus heterophylla are variable in terms of the onset of the main phenophases; individuals of the Euonymus maackii species have minimal individual variability. The longest growing seasons on the phenological spectrum were registered in 2014 and 2018–2019 (in Corylus heterophylla individuals – 190 days), which contributes to the accumulation of more phytomass. The shortest growing season was registered in 2015 (Armeniaca sibirica – 150 days).
Pengaruh Kinerja Komite Sekolah dan Kepemimpinan Kepala Sekolah Terhadap Peningkatan Mutu Pembelajaran Pendidikan Agama Islam
Authors: Nurafni Kamsia , Saguni Fatimah , Hasnah Sitti 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kinerja komite sekolah terhadap peningkatan mutu pembelajaran, pengaruh kepemimpinan kepala sekolah dalam peningkatan mutu pembelajaran, dan pengaruh kinerja komite sekolah dan kepemimpinan kepala sekolah terhadap peningkatan mutu pembelajaran Pendidikan Agama Islam, Penelitian ini menggunakan metode kuantitatif. Adapun yang menjadi variabel dalam penelitian ini adalah kontribusi kinerja komite sekolah, kepemimpinan kepala sekolah dan peningkatan mutu pembelajaran Pendidikan Agama Islam. Data diolah dengan SPSS versi 21. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan antara Pengaruh Kinerja Komite Sekolah dengan Peningkatan Mutu Pembelajaran sebesar 37,8% dan selebihnya 62,2% dipengaruhi oleh faktor-faktor lain di luar penelitian. Berarti semakin tinggi pengaruh kinerja komite sekolah maka semakin tinggi pula peningkatan mutu pembelajaran Pendidikan Agama Islam. Hasil ini menunjukkan bahwa komite sekolah merupakan suatu lembaga yang berkedudukan disetiap satuan pendidikan, serta merupakan badan mandiri yang tidak memiliki hubungan hierarki dengan lembaga pemerintahan yang berada di tengah-tengah antara orang tua murid, murid, guru, masyarakat setempat. Terdapat pengaruh kepemimpinan kepala sekolah terhadap peningkatan mutu pembelajaran sebesar 66,4% dan selisihya 33,6% dipengaruhi oleh faktor-faktor lain di luar penelitian. Berarti bahwa semakin tinggi pengaruh kepemimpinan kepala sekolah maka semakin tinggi pula peningkatan mutu pembelajaran. Hal ini disebabkan karena kepala sekolah mampu mempengaruhi orang lain dan bersedia bekerja sama untuk mencapai tujuan pembelajaran. Analisis secara bersama-sama terdapat pengaru yang sangat signifikan kinerja komite sekolah dan kepemimpinan kepala sekolah terhadap peningkatan mutu pembelajaran pendidikan agama Islam. Implikasi dalam penelitian ini adalah kurang maksimalnya kepala sekolah dalam membina dan membimbing guru-guru, sehingga masih ada guru yang kurang disiplin dalam bertugas, terlambat datang dan pulang lebih awal. kondisi seperti itulah yang menjadi permasalahan di lembaga pendidikan. Tugas pokok kepala sekolah dari penciptakan komunitas pembelajar, leader, manajer, dan supervisor. Kepala sekolah sebagai pencipta komunitas pembelajaran.
Pengaruh Kualitas Produk, Kualitas Layanan, dan Kepuasan Konsumen terhadap Loyalitas Konsumen pada Kopi Tuku di Tangerang dan Jakarta Barat
Authors: Gunawan Bryan Geraldy , Widoadmodjo Sawidji 
Published: March 2022

This study was conducted to determine whether there is a positive and significant effect of Product Quality on Customer Loyalty, second to find out whether there is a positive and significant effect of Service Quality on Customer Loyalty, third to determine whether there is a positive and significant effect of Customer Satisfaction on Customer Loyalty and fourth to determine whether there is a positive and significant effect of Customer Satisfaction on Customer Loyalty. determine whether there is a positive and significant influence between Product Quality, Service Quality, and Customer Satisfaction on Customer Loyalty. The population used in this study were Customers of the Tuku Coffee Shop in Tangerang and West Jakarta. The number of respondents in this study was 200 people, with non-probability sampling techniques and convenience sampling. Data processing was then carried out with the PLS program and tested each hypothesis. The results are: (1) Product Quality has a positive influence on Customer Loyalty (2) Service Quality has a positive influence on Customer Loyalty (3) Customer Satisfaction has a positive influence on Customer Loyalty (4) Product Quality, Service Quality, and Customer Satisfaction have a positive influence on Customer Loyalty. Customer Loyalty. Penelitian ini dilakukan bertujuan untuk mengetahui apakah ada pengaruh positif dan signifikan Kualitas Produk terhadap Loyalitas Konsumen, kedua untuk mengetahui apakah ada pengaruh positif dan signifikan Kualitas Layanan terhadap Loyalitas Konsumen, ketiga untuk mengetahui apakah ada pengaruh positif dan signifikan Kepuasan Konsumen terhadap Loyalitas Konsumen dan keempat untuk mengetahui apakah ada pengaruh positif dan signifikan antara Kualitas Produk, Kualitas Layanan dan Kepuasan Konsumen terhadap Loyalitas Konsumen. Populasi yang digunakan didalam penelitian ini adalah konsumen dari Kedai Kopi Tuku yang berada di Tangerang dan Jakarta Barat. Jumlah responden dalam penelitian ini sebanyak 200 orang, dengan teknik nonprobability sampling dan convenience sampling. Pengolahan data kemudian dilakukan dengan Program PLS dan melakukan pengujian pada masing-masing hipotesis. Hasilnya ialah: (1) Kualitas Produk memiliki pengaruh positif terhadap Loyalitas Konsumen (2) Kualitas Layanan memiliki pengaruh posisitf terhadap Loyalitas Konsumen (3) Kepuasan Konsumen memiliki pengaruh positif terhadap Loyalitas Konsumen (4) Kualitas Produk, Kualitas Layanan dan Kepuasan Konsumen memiliki pengaruh positif terhadap Loyalitas Konsumen.