bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthropometric Analysis of Human Knee Joint in Indian Population
Authors: Ambade Ratnakar , Jaiswal Ankit 
Published: January 2022

Background: It is well understood that distal femoral and proximal tibia scale is lower in case of the Asian than that of their western counterparts. Because of the Asian population's comparatively smaller structure and stature, many surgeons claim that imported implants may not be well fitted for Asian origin patients, mainly based on Western morphometry. It is very likely that an overweight section will be used in many Asian centres in most operations, resulting in low results of the procedure of the implant. For joint substitution of distal femur, careful positioning of fitted implants as well as balancing of underlying soft tissues is important. It is also important to use incredibly complex surgical procedures. To retain its usual functional motion spectrum, use of a suitable femoral part dimension is necessary. Furthermore, owing to a discrepancy between the size of the prosthesis and the bone, there could be a host of serious issues.
Objectives: To calculate the anthropometric distal femur parameter and determine the distal femur variations on the right and left side of the morph metric measurement and to evaluate dimension of current TKA as related to Indian population.
Methodology: This study included visiting the out patients Department of Orthopedics, at AVBRH in the age group 30-50 year during the period of June-2020 to April-2023 with sample size of 50 patients.
Detailed history and clinical review will be taken, including age, sex, socio-economic background, type of employment. In all patients involved in the study in Orthopedic OPD, thorough radiological assessment of all the knee joints will be performed. The radiological test and various anthropometrics will include knee joint Simple X-ray and CT-Scan.
Expected Results: We expect that from our results, anthropometric measurements of Indian population may differ from other literatures.
Otorhinolaryngological Manifestations in COVID-19: Review of Recent Evidence
Authors: Alherabi Ameen Z. , Alharthi Bassam T. , Felemban Jeehad M. , Alharthi Hareth H. , Alrefai Mohammed T. 
Published: January 2022

Objectives: In this review we provide an updated concise review about the most common Otorhinolaryngological symptoms in COVID-19 patients.
Methods: A searched strategy designed on published literature in different large medical databases and journals using various keywords to get the recent described manifestations.
Results: 25 included studies that focused on ENT symptoms and involved the confirmed cases only. 6276 patients were accounted for the results which showed that the most prevalent ENT manifestation were cough in 3498 (56%) patients, headache in 2013 (32%) patients, sore throat in 1966 (31%) patients, anosmia in 1340 (21%) patients, loss of taste in 914 (15%) patients, and rhinorrhea in 196 (3%) patients.
Conclusion: Cough was the commonest symptoms which should raise the suspicion to do COVID-19 swab especially if associated with smell and taste disorder.
Implication of Buteyko Breathing Technique in Asthmatic Population: A Literature Review
Authors: Patil Saloni , Rani P. Shilna , Kumar K. U. Dhanesh 
Published: January 2022

Background: Complementary and experimental medicine is gaining interest in the treatment of asthma around the world. This study summarizes the literature on complementary and alternative medicine approaches that use breathing retraining, i.e Buteyko breathing technique (BBT) as a primary component.
Aim: The aim of this research is to provide background for BBT, analyse the available evidence for its efficacy and evaluate the physiological framework behind it.
Methods: The analysis of literature is carried out by studying papers from electronic databases such as Cochrane, Medline, Embase, AMED, PEDro, Google Scholar, Elsevier, APTA, Campbell, Web of Science, and Research Gate.
Conclusion: Individual studies using BBT consistently showed a reduction in asthma medication use. In either of the BBT experiments, no significant difference in lung ability was found. BBT detractors argue that drug reduction can be due to the physicians' influence, which is difficult to determine. Longer follow-up is needed to show that the improvement in asthma treatment as measured by drug usage is sustained over a clinically appropriate time span.
COVID-19: Source, Symptoms, Screening, Prevention and Treatment
Authors: Suda Nikita , Jha Rakesh Kumar , Meshram Supriya 
Published: January 2022

Background: COVID-19 is an infectious disease caused by the newly acquired SARS-COV2 virus. The disease is rapidly changing, as well as our understanding of the emerging virus. Not knowing what it was at the beginning of the year 2020, scientists have been able to classify, track, classify, and establish diagnostic tests. Severe illness may strike the elderly and those with chronic illnesses, such as heart disease, diabetes, or cancer.
Conclusion: Over the past four decades, the emergence of new infectious, global threats has reshaped national and international thinking and the level of public health responses needed to combat these threats. All countries are at risk of new diseases, according to International Health Regulations.
A New Genetic Insight for Orphan Renal Disorder, Fabry: A Review
Authors: Karemore Pragati , Kumar Dinesh , Kumar Anil 
Published: January 2022

Fabry is the rare X-linked genetic disorder caused due to mutation in Alpha –Galactosidase encoding GLA gene mutation in chromosome number 22. It has wide diversification in prevalence due to clinical heterozygosity. There are some potential biomarkers for the evaluation of normal or altered genes responsible for Fabry. Advances in the research of biomarkers over the years have made significant development for several clinical indicators, viz. urine-derived cells, oxidative stress, DNA methylation, etc. At present days the recommended therapies for the disease are Enzyme Replacement Therapy (ERT), Chaperone therapy (CT), and mRNA-based therapy, besides, some second-generation therapies which are still under clinical trials.
Three Distomolar in Single Patient: A Unique Case Report
Authors: Rasheed M. Jaafari, Fatimah , Somili Alanood Mansour , Rubaydi Ghaliah Ahmed , Masmali Lujain Mahdi Hussin , Ali Fareedi Mukram 
Published: January 2022

Supernumerary teeth are defined as those in addition to the normal series of deciduous or permanent dentition. Supernumerary teeth are more prevalent among males and in the permanent dentition. The exact etiology of supernumerary teeth is unknown, they may occur anywhere in the oral cavity. They may appear as a single tooth or multiple teeth, unilaterally or bilaterally, erupted or impacted in maxilla or both jaws.
Fourth molars, also called distomolars, are a variant in shape and number appearing as alterations during odontogenesis. They can be eumorphic or dismorphic, single or multiple, erupted or impacted, unilateral or bilateral, and can appear in both jaws. They are of unknown etiology, but there are several theories to justify these tooth alterations such as dental lamina duplication, its horizontal proliferation or its hyperactivity.
Hereby, we are presenting a unique case report of presence of three distomolars in a single patient at maxillary left side and mandibular right and left side.
A Study to Assess the Effectiveness of Planned Teaching Programme on the Knowledge Regarding Management of Pre-Eclampsia among Antenatal Mothers
Authors: Chaudhari Mahesh K. , Dandade Shiwani P. , Borkar Saurabh D. , Borkar Shivani K. , Teltumbde Archana 
Published: January 2022

Background of the Study: Pre-eclampsia is a multisystem disorder with an unknown aetiology that appears as hypertension of 140/90 mm hg or higher with proteinuria after the 20th week in a previously normotensive and non-proteinuric woman. Pre-eclampsia is unique among hypertension illnesses in terms of the effects it has on maternal and newborn health. It is a leading cause of maternal and neonatal mortality and morbidity around the world.
Objectives of the Study: 1. To assess the existing knowledge regarding pre-eclampsia among antenatal mothers. 2. To evaluate the effectiveness of planned teaching on knowledge regarding pre-eclampsia among antenatal mothers. 3. To find out the association between knowledge score with selected Demographic variables.
Materials and Methods: 100 samples were taken from selected Hospital Wardha by Non probability sampling technique. Research design descriptive survey was used. Statistical compare ANOVA and t-test formula used.
Results: In pre test Antenatal mothers have 65% fair knowledge regarding pre-eclampsia , and mean knowledge score was 2.02%. In post-test of Antenatal mothers have 52% Excellent knowledge and mean knowledge score was 0.97 % regarding management of pre-eclampsia.
Conclusion: It is concluded that In Pre – test level of knowledge score fair was 65 % and mean knowledge score was 2.02 % And In Post - test level of knowledge score excellent was 52 % andmean knowledge score was 0.97 %. Study conclude that their is lack of knowledge of Pre-eclampsia among antenatal mothers. After the completion of the study it is revealed that the planned teaching program was effective in gaining the knowledge regarding management of pre-eclampsia among antenatal mothers. It can improve their health status and prevent from sideeffect.
A Review on Myths and Facts about COVID-19
Authors: Sheikh Areeba Abid , Jain Pradip , Patel Praful 
Published: January 2022

Background: Myth is widely held but false idea or a belief. It is usually backed by religious, traditional , customs and rituals which tries to manipulate public mindset. Since the spread of Covid-19 Pandemic, myths are being believed by people .In this review article I am providing information about Myths and its actual facts about COVID-19 which are essential to be known so as to stop the spread of Myths by some set of people for own gains or either due to lack of Scientific Information It takes too long to debunk a myth by presenting facts.
Conclusion: Myths have been believed by common people at large whenever a new disease or virus is identified. These Myths have potential to spread more vigorously than the virus itself Myths can have detrimental effects on various aspects of physical, mental and social health. These myths should be curbed by providing evidence based information which can stop its spread. Therefore strict possible measures as discussed above should be taken by respective authorities.
Case Report on Rom Exercises Effective in Reducing Pain and Discomfort in Hodgkin’s Lymphoma
Authors: Nade Viwek , Tembhare Vaishali , Ankar Ruchira , Sakharkar Sheetal , Dhengare Archana , More Swapana , Sakharwade Prerana , Meshram Khushbu 
Published: January 2022

Introduction: Hodgkin lymphoma, which also accounts up 11% of all lymphomas, is named Hodgkin's disease. This malignant disease is known as the Reed-Sternberg-cell, which is situated in lymph-nodes and is characterized by the proliferation of irregular gait. The disease occurs more often in those between 15-30 years and over 55 and is doubling prevalent in women, in men and women. The sickness is bimodal age specific. The frequency in India is around 1 in 25,000 inhabitants. However, for all stages, long-term survival is around 80%.
Clinical Findings: The onset of symptoms is usually insidious but usually used for frequent diagnosis are: Extension of lymph nodes in area of cervical, axillary or inguinal, extraordinary weight loss, Fatigue, Weakness, fever, chills, tachycardia, sweating or nocturnal sweat.
Diagnostic Evaluation: Peripheral analysis of the blood, Biopsy of Excision of lymph node, Examination of bone marrow, Radiological study
Therapeutic Management: Chemotherapy and radiation therapy or some may need immunotherapy or stem cell transplant.
Outcome: After treatment, the child showed great improvement.
Conclusion: A 11 year male child was admitted to pediatric ward no.22 in AVBRH on 25/05/2021 with a unique case of Hodgkin’s lymphoma with severe pain and discompfort. He was admitted in hospital and all investigation and treatment were started. After getting medical treatment and physiotherapy he shows great improvement and the treatment was still going on till my last date of care.
Development and Validation of Ultraviolet and Reverse Phase-high Performance Liquid Chromatographic Method for Estimation of Cilnidipine
Authors: Samantaray Biswajit , Panda Jagannath , Mahapatra Satyapriya , Ray Kajal , Kanhar Satish 
Published: January 2022

Aim: The current experiment was to develop and validate a straight forward RP-HPLC methodology for the determination of Cilnidipine.
Methodology: UV spectroscopy was used to estimate Cilnidipine. Action separation of Cilnidipine was achieved by employing a C18 column. Mobile phase combination of methanol: water (90:10 v/v) was tense at the flow of 1 ml/min. Detection was performed at 241 nm. Validation parameters were evaluated in line with the International conference on harmonization (ICH) Q2R1 guidelines.
Results: The standardization curve was linear within the varying concentration of 2-10 mg/ml for Cilnidipine with parametric statistic (r2) equal to 0.999. The tactic was found to be accurate (101.66% recovery), precise (intraday, 1.65 and inter day, 1.38) and robust (% RSD was calculated to be 0.66, 0.58 and 0.81 for variation in mobile phase composition, wave length and flow velocity respectively) for the analysis of Cilnidipine.
Conclusion: The developed method has passed all the validation tests and can be successfully applied to estimate the presence of Cilnidipine in bulk as well as in pharmaceutical formulations.
Comparitive Study of Glutathione-S-Transferase Isoenzyme and Vitamin D Levels in Smokers and Non-smokers
Authors: Ambad Ranjit S. , Nagtilak Suryakant , Hawale Dattu , Anjankar Ashish 
Published: January 2022

Background: In developed countries, cigarette smoking is the leading preventable cause of morbidity and mortality. In the second half of this century, dramatic changes in the prevalence of cigarette smoking in the United States reduced current smoking levels to approximately one quarter of the adult population, reducing gender differences in smoking prevalence and smoking-attributable diseases. Cigarette smoking is a serious risk factor for lung cancer, which is the leading cause of cancer-related deaths in both men and women in the United States and around the world.
Aim: Comparative Study of Glutathione-S-Transferase Isoenzyme mu and Vitamin-D Levels in Smokers and Non-Smokers.
Materials and Methods: A total of 100 people aged 20 to 55 years old who came to Shalinitai Meghe hospital in Nagpur for a health check-up were chosen for the research. Non-smokers make up the control group, while smokers make up the research group. There are 50 patients in each group. ELISA was used to determine vitamin D status. An enzyme-linked immunosorbent assay was used to detect GST-µ in heparinized whole blood.
Results: GST-µ was found to be mostly positive in smokers, and it was also found to be raised in heavy smokers (6.39±3.2) than light smokers (4.56±0.78). GST-µ is positive in light smokers. GST-µ is nearly equal in smokers (5.24±0.95) and heavy smokers relative to others.
Conclusion: Quitting smoking for a longer period of time was related to higher vitamin D levels than current smoking. Furthermore, the GST-µ measure used in our research may be used to show differences in cytogenetic damage between smokers who have a genetically defined detoxification enzyme and those who do not.
Circulatory Glutathion S Transferases Estimation in Chronic Alcoholics Vising Urban and Rural Health Center
Authors: Ambad Ranjit S. , Nagtilak Suryakant , Bhadarge Gangaram , Kaple Meghali 
Published: January 2022

Introduction: Excessive alcohol consumption is a global healthcare problem with enormous social, economic, and clinical consequences, accounting for 3.3 million deaths in 2012. Glutathione (GSH) is tri-peptide thiol with chemical name γ glutamyl-cysteinyl-glycine the properties of glutathione are conferred to it by highly reactive thiol present in one of its constituent amino acids- cysteine, hence they referred as GSH. Xenobiotics form thioether (-S) linkage with GSH. The reaction is catalysed by enzyme known as glutathione S Transferases (GSTs). The cytoplasmic GSTs are important in the xenobiotic metabolism and are present in higher concentration in liver.
Materials and Methods: The present study was conducted in the Dept. of Biochemistry in collaboration with Dept. of General Medicine at Datta Meghe Medical College, Nagpur. In present study includes 40 diagnosed alcoholic liver disease patients and 40 non-alcoholic healthy subjects as control group who are permanent nt of study area.
Results: The level of GST was raised in chronic alcoholic patients i.e. study group (43.25±15.94) as compare to control group (1.57±0.55). At the other hand the level of total thiol were decreased in study group (3.12±0.55) as compare to control group.
Conclusions: The strong negative association between glutathione-s-transferase (GST) and total thiol (T-SH) levels suggested that as the concentration of total thiol (T-SH) decreased, glutathione-s-transferase activity increased (GST). This may be attributed to an increase in alcohol-induced oxidative stress and increased T-SH utilization from thiols.
The Indian Lessons to be Learnt from COVID-19 Pandemic
Authors: Wavare Sonali , Dhengare Archana 
Published: January 2022

Emerging pandemics indicate that people are not infallible and that communities need to be prepared. Coronavirus COVID-19 outbreak was first identified in late 2019, and has now been declared a World Health Organization pandemic. Countries around the world are reacting to the virus outbreak differently. On the other hand, several other nations have put in place successful measures to control the virus, reporting a relatively limited number of cases since the pandemics started. Restrictive steps such as social distancing, lockdown, case identification, isolation, touch monitoring and exposure quarantine had shown the most effective acts to monitor the spread of the disease. This review will help readers understand that this invisible and ‘omnipresent’ virus has taught a lesson for the first time in human history that whatever human power might have, it could not subjugate every living being in this world. This has been confirmed once again by the recent invasion of this human virus. Difference in the answers of the different countries and their outcomes, based on that country's experience, India responded accordingly to the pandemic. Only time will tell how well India comes up against the outbreak. We also propose the potential approaches the global community will take in handling and minimizing the emergency.
Is the Urine Analysis, a Diagnostic Value in COVID-19 Patients?
Authors: Sulochana Sonti , Asokan Lakshmi Priya , Mathesh . , Srinivasan Chitra 
Published: January 2022

Background: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), a novel coronavirus causing Coronavirus disease 19 (COVID-19) in December 2019, is now a pandemic infectious disease, primarily affecting the respiratory tract. To date, many investigations are available for the diagnosis of SARS-CoV-2. A viral nucleic acid test has been used for the diagnosis of COVID-19, and some hematological indicators have been used in the auxiliary diagnosis and identification of the severity of COVID-19. There are very few studies available in routine urine biochemical parameters and their relation with Covid-19 patients.
Aim: This study is aimed to study the changes in urine parameter values in COVID-19 disease and to predict the severity of the disease with the changes in urine parameters.
Materials and Methods: A total of 150 patients with COVID-19 were admitted at Saveetha Medical College and Hospital during the study period. All cases tested positive for SARS-CoV-2 by RT-PCR test done on nasopharyngeal swabs during the study period were included. Patients who tested negative by RT-PCR test were considered as controls. The relationship between the results of urine biochemical parameters and the severity of COVID-19 were analysed by Descriptive statistics, Chi-squared test.
Results: The positive rates of proteinuria (PRO) and leucocytes were more significant in COVID-19 patients than in healthy controls. The urine specific gravity (SG) value was highly significant (p <0.001) while the blood, nitrites in urine, and potential of hydrogen (pH) value was insignificant.
Conclusion: There were some considerable changes in few urine biochemical parameters between patients with the SARS-CoV-2 and healthy controls. So from this study we conclude, proteinuria is helpful for predicting COVID-19 severity and kidney function.
Oral Submucous Fibrosis with and without Associated Oral Squamous Cell Carcinoma
Authors: Masoud Ahmad , Shafique Muzzamil , Arif Faiza 
Published: January 2022

Introduction: Oral submucous fibrosis (OSF) is a potentially malignant disorder of the oral cavity.
Aims and Objectives: The core objective of the study is to analyze the oral submucous fibrosis with and without associated oral squamous cell carcinoma (OSCC).
Materials and Methods: This cross sectional study was conducted in Baqai Dental College Karachi during October 2020 to June 2021. The data was collected from 100 patients of both genders who were confirmed with OSF on the basis of history and clinical examinations were included in the study. Demographic and clinical information were recorded.
Results: The data were collected from 100 patients of both females and males. The age distribution of the sample was analyzed. The patients were mostly above 50 years of age in both categories. However, the number of patients who were with OSCC at an age below 50 was greater in the OSF-positive group (23.8% vs. 21.9%). Similarly, the mean age of OSF + OSCC patients was 57.5 years while this value was 59.5 years for those without.
Conclusion: It is concluded that tumors show well-differentiated histology and less lymph node involvement. However, a statistical significance was not observed among these variables, when comparing the OSCC patients with OSF to those who are without.
Effectiveness of Perioperative Local Use of Anesthetics and Antiseptics in Patients with Purulent-necrotic Lesions of Lower Extremities in Diabetes Mellitus
Authors: Babina Yuliana , Dmyrtriiev Dmytro , Nazarchuk Oleksandr , Hormash Pavlo , Vernyhorodskyi Serhii 
Published: January 2022

Background: Every second patient with the diabetes mellitus (DM) needs surgery due to purulent-necrotic changes in the feet.
The aim of the study was comparative morphological examination of the course of the wound process in purulent-necrotic lesions of the lower extremities of patients with DM with different approaches to local treatment in the perioperative period.
Materials and Methods: We investigated changes in the histological structure and the nature of the reactions of skin tissues, muscles and fascia during the healing of an ulcer in patients with the diabetes mellitus after various types of local treatment. Then the specimens were photographed and analyzed using the OLIMPUS BX 41 light microscope.
Results: In the first comparison group, which used standard anesthesia techniques and locally antiseptic povidon-iodine - granulation tissue was characterized by the complete absence of fibrous structures and the presence of a small number of small-sized neoplastic vessels with swollen endothelium. And in patients of the II observation group who received locally decamethoxin and infiltration anesthesia with a 2% solution of lidocaine after surgery during the study of histological preparations of the affected tissues, a significant decrease in signs of pathological vascular reaction was established compared with the comparison group.
Conclusions: In group 1 (control) healing of wounds on the third-seventh day is characterized by somewhat slow regeneration. Wound healing was most favorable in patients of the second group, where infiltration anesthesia was used by local anesthetic and antiseptic decamethoxin.