bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk assessment and exploration on invasive peculiarities of ornamental grasses to the urban greening routine
Authors: Chen Chao , Teng Wen-Jun , Zhang Hui , Wu Ju-Ying , Scullion John , Bye Ruby 
Published: October 2022

Abstract
Two risk assessment protocols, the Weed Risk Assessment for Central Europe (WG-WRA) and the Australian Weed Risk Assessment (WRA), were adapted to evaluate the invasion risk of eighty-two ornamental grasses. Meanwhile, some particular characteristics of these ornamental grasses, like ornamental value, biological and ecological characteristics were highlighted and assessed for their potential risk by field observations and method of expert ranking. There was a positive correlation between scores derived from the two risk protocols, though WRA was considered to be more acceptable than WG-WRA according to the analysis of ornamental grasses. Well-cultivated cultivars were less-efficiently predicted by the two risk protocols compared with the protospecies in the study, as well as some outliers with higher fecundity. In details, the risk classification differed: risk categorization using the WG-WRA protocol allocated high and moderate risk to 81.1% of 45 native ornamentals, yet only 22.2% of 37 alien ornamentals. Assessment using the WRA protocol scored 91.5% of the studied ornamentals to pose invasion risk following a diverse criterion, of which 97.3% were for native species and 86.7% for alien species. Ranked scores of biological and ecological characteristics of ornamental grasses highlighted herein were correlated with risk scores, although the significance of these relationships varied; while ornamental value had a weak relationship to the risk scores. In addition, some features peculiar to ornamental grasses relating to their invasive tendency are presented that most (72.0%) of the alien ornamentals exhibit perenniality, intentionally introduced from the Americas and Europe, and to a lesser extent from Asia, Africa, and Australia. In general, the ornamentals with high fecundity and adaptability presented a higher risk of invasion, while well-domesticated cultivars or hybrid species with high aesthetic scores yet relatively low levels of fecundity and adaptability, presenting a low invasion risk.
Dabrafenib plus trametinib treatment in patients with anaplastic thyroid carcinoma: the Argentinian experience
Authors: Bueno Fernanda , Smulever Anabella , Califano Inés , Guerra Jorguelina , Grecco Andrés Del , Carrera Juan Manuel , Giglio Raúl , Rizzo Manglio , Lingua Alejo , Voogd Ana , Negueruela María del Carmen , Abelleira Erika , Pitoia Fabián 
Published: October 2022

Abstract
Purpose: To present our real-life experience with dabrafenib and trametinib (D-T) treatment in patients with BRAF V600E-mutated ATC in Argentina. Patients y
methods: We included five patients from four different hospitals. The median age was 70 years, and 60% were male. The performance status at diagnosis was grade 0 in 60% and grade 2 in 40% of patients. Four patients could undergo total thyroidectomy; in one of them, surgical treatment was amenable due to the indication of D-T as neoadjuvant therapy. From the total cohort, the best response to treatment was complete response in 40%, partial response in 20%, and stable disease in 20%. The median duration of response was 20 weeks; ranging from 16 to 92 weeks. All patients experienced at least one adverse event (AE). Grade ≥3 AEs were observed in two (40%) patients. They were upper gastrointestinal bleeding and subclavian vein thrombosis. The median follow-up was 20 weeks (range: 16 to 92).
Conclusion: This report contributes to illustrate the feasibility and effectiveness of D-T treatment in five patients with loco-regionally advanced and metastatic BRAF V600E-mutated ATC in a real-life setting. A multidisciplinary approach and rapid molecular tailored testing are essential to begin this therapeutic option.
USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer
Authors: Zhang Pengju , Xiao Yi , Jiang Xiaoyu , Miao Tianshu , Lu Hanlin , Wang Wenqing , Ma Lijuan , Zhao Yinghui , Liu Chunyan , Qiao Yun 
Published: October 2022

Abstract
Ubiquitin-specific-processing proteases 35 (USP35) is an under-characterized deubiquitinase and its role in colorectal cancer (CRC) remains unclear. Here, we focus on delineating the impact of USP35 on CRC cell proliferation and chemo-resistance, as well as the possible regulatory mechanism. By examining the genomic database and clinical samples, we found that USP35 was overexpressed in CRC. Further functional studies showed that enhanced USP35 expression promoted CRC cell proliferation and resistance to oxaliplatin (OXA) and 5-fluorouracil (5-FU), whereas USP35 depletion impeded cell proliferation and sensitized cells to OXA and 5-FU treatments. Then, to explore the possible mechanism underlying USP35-triggered cellular responses, we performed co-immunoprecipitation (co-IP) followed by mass spectrometry (MS) analysis and identified α-L-fucosidase 1 (FUCA1) as a direct deubiquitiation target of USP35. Importantly, we demonstrated that FUCA1 was an essential mediator for USP35-induced cell proliferation and chemo-resistance in vitro and in vivo. Finally, we observed that nucleotide excision repair (NER) components (e.g., XPC, XPA, ERCC1) were up-regulated by USP35-FUCA1 axis, indicating a potential mechanism for USP35-FUCA1-mediated platinum resistance in CRC. Together, our results for the first time explored the role and important mechanism of USP35 in CRC cell proliferation and chemotherapeutic response, providing a rationale for USP35-FUCA1-targeted therapy in CRC.
Application value of cardiac magnetic resonance image fusion technique in patients with acute myocardial infarction
Authors: Li Ziwen , Yin Hongbin , Zhang Ziqian , Zhang Yayun , Feng Yongli , Zhou Yi , Zhou Ying 
Published: October 2022

Abstract
Background: Diffusion-weighted imaging (DWI) is feasible for detecting acute myocardial edema in patients with acute myocardial infarction (AMI). However, cardiac motion artifacts can cause severe attenuation or loss of DWI signal in well-contracting myocardial segments. Our study aimed to investigate the application value of cardiac magnetic resonance (CMR) image fusion technique in patients with AMI.
Methods: Patients with AMI who underwent percutaneous coronary intervention and CMR were prospectively enrolled. Image fusion was performed on cardiac cine imaging and DWI. Using late gadolinium enhancement (LGE) as the reference standard, the acute myocardial edema diagnostic efficiency, image quality score and correlation with infarct size were compared between DWI and cine-DWI.
Results: A total of 52 patients with AMI were enrolled in this study. No significant difference was found in the positive rate of acute myocardial edema diagnosis between DWI and cine-DWI (92.3% vs. 96.2%, p = 0.500). Cine-DWI had higher normal and overall myocardial scores than DWI (all p < 0.001); no significant difference was observed in edematous myocardial score between DWI and cine-DWI (p = 0.239). The correlation coefficient r between the edema area measured using DWI and the infarct size measured using LGE was 0.826 (p< 0.001); and the correlation coefficient r between the edema area measured using cine-DWI and the infarct size measured using LGE was 0.905 (p< 0.001) .
Conclusions: Compared with DWI, the fusion image base on cine and DWI improved the image quality, and its edema area had a stronger correlation with the infarct size measured using LGE.
Intercropping of two maize varieties shifts the bacterial community and enhances nutrient uptake and grain yield under different fertilization managements
Authors: Jia xucun , Song Rui , Chen Yibo , Wang Jingjing , Miao Zhengyan , Zhao Wenlong , Dong Pengfei , Chen Yinglong , Zhang Yongen , Wang Qun 
Published: October 2022

Abstract
Background and aims:
Intercropping contributes to agricultural productivity and resources efficient utilization. However, whether intraspecific intercropping affects rhizosphere bacterial community, nutrient uptake, plant growth and yield remains unknown.
Methods
A two-year lysimetric experiment was conducted using two maize varieties with different root system architectures planted alone (monocropping) or in mixture (intercropping) under normal fertilization (NF), reduced fertilization (RF) or no addition of fertilizer (CK) and was assessed at the silking and maturity stages.
Results
Intercropping increased shoot biomass and total root length at silking stage, and increased the shoot biomass and nutrient uptake at maturity stage and grain yield under NF and RF conditions. Intercropping also increased the bacterial diversity (Shannon index), altered the bacterial community structure, and increased the relative abundance of the class of Bacteroidia under NF and RF conditions compared with the monoculture. The abundance of biomarkers of Chitinophagaceae and Saprospiraceae (Bacteroidia) were relatively higher in the rhizosphere of intercropping under NF and RF conditions compared to these of the monoculture. Moreover, the bacterial network of intercropping was more stable compared with the monoculture under NF and RF conditions, respectively. The bacterial diversity, bacterial community structure and the modularity of bacterial network were significantly positively correlated with plant nutrient accumulation.
Conclusion
Intercropping of maize varieties improved plant growth and nutrient acquisition, which was related to bacterial diversity and community. And distinct bacterial community assembly of intraspecific intercropping of maize could benefit plant nutrient acquisition and plant growth under intensive agriculture.
Explicating the genetic diversity and population structure of Saanen x Beetal goats using pedigree analysis
Authors: Sahoo Shweta , Alex Rani , Vohra Vikas , Mukherjee Sabyasachi , Gowane G.R. 
Published: October 2022

Abstract
Pedigree analysis is required to assess the genetic diversity and population structure of a close breeding population in order to effectively manage the breeding program and keep inbreeding under acceptable limits. Saanen x Beetal is a crossbred population of goats, reared at National Dairy Research Institute (NDRI) Karnal for the last five decades. This germplasm has been acclimated to a tropical climate and has a higher milk potential and prolificacy. Objective of this study was to elucidate the genetic diversity, population structure, and inbreeding in the flock of the Saanen x Beetal goats. The data were collected from the Animal Genetics and Breeding Division of ICAR-NDRI, Karnal for 2603 animals from the year 1971–2021. Animals born between 2014–2017 were considered as a reference cohort. Results revealed that the average generation interval was 3.44 years for the complete pedigree. The average inbreeding coefficient and the average relatedness were 4.20% and 6.87%, respectively, for the complete pedigree and 10.78% and 10.80%, for the reference population. Higher inbreeding coefficient and average relatedness in the reference cohort demonstrated impact of enclosed gene pool and demands immediate intervention for managing diversity in the closed nucleus under study. Ancestors contributing 50% of the gene pool were 8 and 3 for the complete pedigree and reference cohort, respectively, which illustrates the fact that very few ancestors were responsible for genetic diversity in the flock, which results in the decline of effective population size. Effective number of founders (fe), ancestors (fa), and founder genome equivalents (fg) were 15, 7, and 3.11, respectively. The (fe/fa) ratio in the reference population was 2.14 indicating the occurrence of the bottleneck effect in the flock. We observed that inbreeding was non-significant for all reproductive traits except for age at first service and age at first kidding. To lessen inbreeding and augment genetic diversity in the flock, the stratified breeding plan needs to be followed, where, mate sele ction would be based on relatedness. Furthermore, introduction of unrelated Saanen and Beetal crosses will help alleviate the inbreeding accumulation.
Step engineering for nucleation and domain orientation control in WSe2 epitaxy on c-plane sapphire
Authors: Zhu Haoyue , nayir Nadire , Choudhury Tanushree , Bansal Anushka , Huet Benjamin , Zhang Kunyan , Puretzky Alexander , Bachu Saiphaneendra , York Krystal , Knight Thomas Mc , Trainor Nicholas , Wang Ke , Makin Robert , Durbin Steven , Huang Shengxi , Alem Nasim , Crespi Vincent , Duin Adri Van , Redwing Joan 
Published: October 2022

Abstract
Epitaxial growth of 2D transition metal dichalcogenides (TMDs) on sapphire has emerged as a promising route to wafer-scale single crystal films. Steps on the sapphire act as sites for TMD nucleation and can impart a preferred domain orientation resulting in a significant reduction in mirror twins. Here we demonstrate control of both the nucleation site and unidirectional growth direction of WSe2 on c-plane sapphire by metalorganic chemical vapor deposition (MOCVD). The unidirectional orientation is found to be intimately tied to growth conditions via changes in the sapphire surface chemistry which control the step edge location of WSe2 nucleation imparting either a 0° or 60° orientation relative to the underlying sapphire lattice. The results provide insight into the role of surface chemistry on TMD nucleation and domain alignment and demonstrate the ability to engineer domain orientation over wafer-scale substrates.
Arthropod beta-diversity is spatially and temporally structured by latitude
Authors: Seymour Mathew , Roslin Tomas , deWaard Jeremy , Perez Kate , D'Souza Michelle , Ratnasingham Sujeevan , Ashfaq Muhammad , Levesque-Beaudin Valerie , Blagoev Gergin , Bukowski Belén , Cale Peter , Crosbie Denise , Decaëns Thibaud , deWaard Stephanie , Ekrem Torbjørn , Elansary Hosam , Ondo Fidèle Evouna , Fraser David , Geiger Matthias , Hajibabaei Mehrdad , Hallwachs Winnie , Hanisch Priscila , Hausmann Axel , Heath Mark , Hogg Ian , Janzen D , Kinnaird Margaret , Kohn Joshua , Larrivée Maxim , Lees David , León-Règagnon Virginia , Liddell Michael , Lijtmaer Darío , Lipinskaya Tatsiana , Locke Sean , Manjunath Ramya , Martins Dino , Martins Marlúcia , Mazumdar Santosh , McKeown Jaclyn , Miller Scott , Milton Megan , Miskie Renee , Morinière Jérôme , Mutanen Marko , Naik Suresh , Nichols Becky , Noguera Felipe , Novotny Vojtech , Penev Lyubomir , Pentinsaari Mikko , Quinn Jenna , Ramsay Leah , Rochefort Regina , Schmidt Stefan , Smith M. , Sobel Crystal , Somervuo Panu , Sones Jayme , Staude Hermann , Jaques Brianne St. , Stur Elisabeth , Telfer Angela , Tubaro Pablo , Wardlaw Timothy , Worcester Robyn , Yang Zhaofu , Young Monica R. , Zemlak Tyler , Zakharov Evgeny , Zlotnick Bradley , Ovaskainen Otso , Hebert Paul 
Published: October 2022

Abstract

Global gradients in species biodiversity are expected to reflect tighter packing of species closer to the equator. Yet, empirical validation of these patterns has so far focused on less diverse taxa, with comparable assessments of mega-diverse groups historically constrained by the taxonomic impediment. Here we assess the temporal and spatial turnover dynamics of arthropod communities sampled across 129 globally distributed monitoring sites. Overall, we encountered more than 150,000 unique BINs (i.e., species proxies). We show that global differences in community compositional change are linked to latitudinal, spatial, and temporal gradients, which are largely consistent across biogeographic regions. This general latitudinal imprint on community composition provides a mechanistic underpinning for global biodiversity gradients.
Decolorization properties and mechanism of reactive-dyed cotton fabrics with different structures utilized to prepare cotton pulp
Authors: Wang Wei , Yin Yuanyuan , Xu Zhixi , Wang Huaifang , Guo Xiaoqing , Gong Zhaoqin , Zhu Ping , Zhang Chuanjie 
Published: October 2022

Abstract
It is critical to develop the mild decolorization technology to accomplish clean pulping in order to overcome the issues caused by the high consumption of energy and severe degradation of cellulose during the preparation of cotton pulp from waste cotton textiles. Discarded cotton fabrics was treated using a technique named as the sodium hydroxide-sodium dithionite system to remove color. During the procedure, the function of decolorization parameters, the effect of decolorization treatment on the structure and properties of cotton fabrics, and mild decolorization mechanism were investigated according to the different chromogenic systems and active groups of reactive dyes, especially. The findings demonstrate that NaOH can hydrolyzes covalent bonds between dye and cotton fiber and Na2S2O4 destroys chromophores to achieve decolorization. The chemical makeup and crystal structures of cotton cellulose are barely affected throughout the decolorization process. It is worth noting that the strength of the decolored cotton fabric can be retained by more than 90%, thus not affecting the subsequent pulping requirements.
Treatment satisfaction with molidustat in CKD-related anemia in non-dialysis patients
Authors: Yamamoto Hiroyasu , Yamada Takashi , Miyazaki Ken , Yamashita Takuto , Kato Takuya , Ohara Kenichi , Nakamura Yusuke , Sakai Yoko , Crawford Bruce , Akizawa Tadao 
Published: October 2022

Abstract
Erythropoiesis-stimulating agents (ESAs) are a standard treatment for patients with renal anemia to increase hemoglobin (Hb) levels and reduce their need for blood transfusions. However, treatments targeting high Hb levels require high doses of ESAs by the intravenous injection which are associated with an elevated risk of adverse cardiovascular events. In response to this key limitation other erythropoietin-promoting medications have been developed such as hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PH inhibitor). This post-hoc analysis of two clinical trials evaluates patients’ treatment satisfaction with a HIF-PH inhibitor, molidustat, compared to a standard ESA, darbepoetin alfa, as part of therapy for patients with non-dialysis chronic kidney disease (CKD) and renal anemia. Exploratory outcome data using the Treatment Satisfaction Questionnaire for Medicine version II (TSQM-II) showed that both arms in both trials had increased treatment satisfaction over the course of the study period as well as improvements in most TSQM-II domains at week 24. Molidustat was associated with convenience domain scores at multiple timepoints depending on the trial and more patients were highly satisfied with the convenience of molidustat compared to darbepoetin alfa. Patients treated with molidustat also had increases in global satisfaction domain scores compared to darbepoetin alfa, but the differences s in global satisfaction domain scores were not significant. These patient-reported satisfaction outcomes provide findings supporting the use of molidustat as a patient-centered treatment option for CKD-related anemia.
Antibiotic susceptibility and resistance of P. aeruginosa uropathogenic isolates
Authors: Khabipova Nailya , Valeeva Lia , Shaidullina Elvira , Mardanova Ayslu , Gimadeev Zufar , Sharipova Margarita 
Published: October 2022

Abstract
Urinary tract infections (UTIs) are one of the most common infectious morbidities among hospitalized patients. Pseudomonas aeruginosa is an important opportunistic human pathogen responsible for the many human infectious diseases. Although, P. aeruginosa provokes only 7–10% of healthcare-associated UTIs, its flexible biochemical and adaptive mechanisms results in the high antibiotic resistance, followed by the increased mortality of patients that makes P. aeruginosaextremely dangerous. A resistance of P. aeruginosa to different classes of antibiotics related to a broad range of its intrinsic, acquired, and adaptive mechanisms including expression of specific β-lactamases. Herein, we studied antibiotic susceptibility of 22 P. aeruginosa urine isolates and the occurrence of metallo-β-lactamases genes in their genomes as one of the main factors of a high resistance to carbapenems. It was shown that all studied P. aeruginosa isolates were resistant or susceptible in increased exposure to carbapenems (imipenem, ceftazidime, and piperacillin/tazobactam) and fluoroquinolone ciprofloxacin. The only effective carbapenem were meropenem, showed inhibition activity against seven isolates. A sensitivity to aminoglycoside class antibiotic amikacin was detected in 82% of the isolates. Only six of isolates contained VIM-type metallo-β-lactamase genes in their genomes.
Women who Ever had Breast Lump: The determinants
Authors: Ngmenbelle David , Ofori Michael Fosu , Antwi Terah 
Published: October 2022

Abstract
Background
Breast lumps or lumpiness are a prevalent issue among women seeking guidance, with 40–70% reporting lumps or lumpiness. Any woman, regardless of age, who discovers a breast lump by self-examination, screening, or medical intervention begins to worry about developing breast cancer. Late stage of reporting suspected lumps is on the rise and this was hitted by the pandemic. The study examined factors that are associated breast lump and the risk on women who ever had breast lump.
Method
An institutional-based cross-sectional study was conducted on women who visited the facility for breast screening or other medical consultation. Closed-ended questionnaire was used to solicit information from 301 women within a period of six weeks. Chi-square and binary logistic regression model was used to determine the association and the risk respectively.
Results
Breast lump was dominant in women between 41–50 years and in those who do not have family history of breast cancer. The findings reveal that educational level [χ2 = 11.170; p = 0.011] and the practice of breast self-examination [χ2 = 7.998; p = 0.005] were significantly associated with breast lump. Married women were 0.764 less likely to have breast lump than those who are singles. Women between 31–40 years were 2 times more likely [AOR = 2.061, CI = 0.876–4.846] and those between 41–50 years 1 time more likely [AOR = 1.131,CI = 0.451–2.837] to have breast lump than women between 18–30 years.
Conclusion
Breast lump is predominant in women between 31–50 years. Factors associated with a woman having breast lump are educational background and the practice of breast self-examination. Surgeon managing a breast lump in women over 30 years old are encouraged to be extremely suspicious and cautious in order to detect and treat malignant lumps early.
Process variations and short channel effects analysis in gate-all-around nanowire field-effect transistor using a statistical Taguchi-Pareto ANOVA framework
Authors: Yau Shi Kai , Hatta Sharifah Fatmadiana Wan Muhamad , Wahab Yasmin Abdul , Aidit Siti Nabila , Hussin Hanim 
Published: October 2022

Abstract
Gate-all-around nanowire field-effect transistor (GAA NWFET) is a viable alternative to reduce short
channel effects. A 3D model of the GAA NWFET was explored by studying the effect of process parameters such as nanowire materials, gate oxide materials and high-κ coverage angles on vital transistor performance metrices specifically threshold voltage, leakage current, current ratio, subthreshold swing (SS) and drain induce barrier lowering (DIBL). It has been observed that the nanowire material of InP provides the lowest threshold voltage and highest drive current. Gate oxide material of HfO2 showed improved leakage current by 88.39%, current ratio by 1439.63%, SS by 24.16% and DIBL by 13.11% relative to the conventional NWFET with SiO2 gate oxide. Moreover, as the high-κ dielectric (HfO2) covers the gate oxide over the channel region, the gate electrostatic control over the channel region increases, thus reducing SS to an ideal value. An exhaustive Taguchi Method with Conceptual Signal-To-Noise Ratio Approach and Pareto Analysis of Variance optimization was conducted to determine the optimal design for high current ratio and low threshold voltage. This work inherently provides a framework in designing an optimized GAA NWFET by considering the device’s highest to lowest domineering design factors in affecting its performance matrices.