bluuebunny/crossref_metadata_2025_split huggingface dataset:
A biophysical model of viral escape from polyclonal antibodies
Authors: Yu Timothy C. , Thornton Zorian T. , Hannon William W. , DeWitt William S. , Radford Caelan E. , Matsen Frederick A. , Bloom Jesse D. 
Published: September 2022

AbstractA challenge in studying viral immune escape is determining how mutations combine to escape polyclonal antibodies, which can potentially target multiple distinct viral epitopes. Here we introduce a biophysical model of this process that partitions the total polyclonal antibody activity by epitope, and then quantifies how each viral mutation affects the antibody activity against each epitope. We develop software that can use deep mutational scanning data to infer these properties for polyclonal antibody mixtures. We validate this software using a computationally simulated deep mutational scanning experiment, and demonstrate that it enables the prediction of escape by arbitrary combinations of mutations. The software described in this paper is available at https://jbloomlab.github.io/polyclonal.
The influence of sustainable design on food well-being
Authors: Tian Yating , Kamran Qeis 
Published: September 2022

PurposeThis study investigates the effects of sustainable design on food policy, literacy, and socialisation to gauge consumers' satisfaction with the general design of food well-being (FWB).Design/methodology/approachUsing data from an online survey with 382 respondents, an empirical study applying composite-based structural equation modelling was conducted. Sustainable design for food socialisation was hypothesised to directly influence consumers' satisfaction with the general design of FWB, whereas food policy was assumed to have an emergent effect on food literacy. Gender was a control variable used to identify the heterogeneity of the effects.FindingsThe results demonstrated that sustainable design for food policy and food literacy positively influence food socialisation and affect consumers' satisfaction with the sustainable design for FWB. Additionally, women exhibited higher application of food knowledge and skills but less experience in FWB than men.Originality/valueTo the best of the authors knowledge, this study is the first to examine the emergent influence of food policy from a design perspective, with implications for industrial practitioners, policymakers, and academic research. This study also provides possible avenues for future sustainability and food product design research.
Exploring the antecedents of high-performance work practices: empirical evidence from Ibero-America
Authors: Gutiérrez-Martínez Isis , Sancho y Maldonado Antonio , Costamagna Rodrigo , Duhamel Francois 
Published: September 2022

PurposeThis article analyzes the impact of the national culture, the dependence of the sector of activity on human capital, and the multinational character of the firm involved, on the degree of implementation of high performance work practices (HPWPs) in Ibero-American companies.Design/methodology/approachThis quantitative study results from a survey of 614 Ibero-American firms, in 6 different countries. Multiple regressions were performed to test the hypothesis proposed.FindingsHPWPs for employee recruitment and selection have been frequently implemented in Ibero-American countries. Three factors, i.e. national culture, degree of multinationality, and degree of dependence of the sector of activity on human capital, have a strong influence on the degree of implementation of HPWPs in general, at different degrees. For example, recruitment and selection practices are conditioned by the degree of multinationality, individualism, uncertainty avoidance, and power distance, while they are not influenced by masculinity and by the sector of activity.Practical implicationsHR managers must align the design and execution of HPWPs with the national culture, and with the characteristics of the sector of activity, they belong to. Domestic companies should also aspire to achieve the higher standards of multinational companies for specific HPWPs.Originality/valueThis study, to the authors’ best knowledge, is the first to provide insights into the influence of the three factors mentioned above on the degree of implementation of HPWPs in Ibero-American firms, using multiple regression analysis. The authors examine in this article a larger set of HPWPs than does most of the existing empirical literature.
The role of market competition for knowledge competencies, R&D and innovation: an empirical analysis for German firms
Authors: Abdul Basit Shoaib , Kuhn Thomas , Cantner Uwe 
Published: September 2022

PurposeKnowledge competencies and (R&D) activities are one of the most important sources of innovation and have been widely discussed in the literature. In comparison, the role of the competitive environment for the innovation activities of firms is still open to debate and has not been fully understood yet. Therefore, this paper intends to provide new evidence on the interaction between knowledge competencies and R&D activities of firms on the one side and their competitiveness in the market environment on the other. In particular, the moderating function of market competition is explored. In this respect, the analysis covers the main innovation types as well as both sectors, manufacturing and services.Design/methodology/approachThe empirical analysis is based on a three years panel dataset of German manufacturing and service firms obtained from Mannheim Innovation Panel (MIP) and Community Innovation Surveys (CISs: 2011, 2013 and 2015). For the estimation, a binary instrumental variable treatment model with Heckman selection method is used. Also, it provides a suitable approach to estimating the binary variables in order to cope with endogeneity concerns.FindingsThe estimation results show that R&D activities and knowledge competencies are positively related to innovation activities of different types conditioned on firms' specific perception of their competitive environment, in terms of outdated products/services as well as strong competition from abroad. Most importantly, the results from the moderation estimation reveal that there is a significant difference between the manufacturing and service sector. Service firms engage more in internal R&D activities on generating product innovations while the manufacturing firms conduct more external R&D on specific types of innovation. Further, the authors find that strong competition from abroad positively and significantly reinforces the effect of knowledge competencies on innovation activities for more types in services than in manufacturing. In contrast, outdated products and services tend to decline the effect of knowledge competencies for some innovation types in both sectors. The authors also observe a positive and significant reinforcement effect on knowledge competencies. However, it is found more beneficial for service firms since they can employ more innovation strategies.Originality/valueThe focus of the study is mainly on the impact of firms' competitive environment on innovation activities in various types through its interaction with knowledge competencies and R&D activities, across manufacturing and service firms.
Migration and financial transactions: factors influencing mobile remittance service usage in the pandemic
Authors: Chang Wei-Lun , Benson Vladlena 
Published: September 2022

PurposeIn the global migration crisis COVID 19 had devastating consequences. Workers were confined to their locations due to travel restrictions and working from home became “working away from home” for millions of migrant workers. Mobile financial services emerged as key to livelihood of the mobile remittance recipients. It is essential for service providers to gain insights of users' motives to use mobile remittance services.Design/methodology/approachThis study proposed the model by extending unified theory of acceptance and use of technology (UTAUT) model and integrating by perceived cost (PC) and perceived security (PS). Based on the survey data (n = 344) the proposed model was tested using analysis of variance (ANOVA) analysis.FindingsThe findings reveal that performance expectancy, effort expectancy, PC and PS affect the users' behavioral intention (BI) to use mobile remittance applications. Social influence nonsignificantly affects the BI and there is no significant influence of facilitating conditions on user behavior.Originality/valueThe volume of migrant workers preCOVID 19 reached 3.5% of the global population, the shear number of unprotected workers plunged into devastation by the COVID-19 impact is huge to cause an economic meltdown. Under the pandemic crisis conditions, the findings provide several practical implications on how service providers could improve their products and services to increase mobile remittance applications usage.
Investigation on vibration parameters in aluminum finned tube arrays subjected to water cross flow
Authors: Yadav Pravin H. , Desai Sandeep R. , Mohanty Dillip Kumar 
Published: September 2022

PurposePredicting the critical velocity is crucial at the instability threshold for shell and tube heat exchangers in order to prevent tube failure due to vibrations. In this study, the vibration response of an aluminum tube bundle subjected to water cross flow was analyzed experimentally. Aluminum tubes are preferred over steel tubes because of aluminum tubes' excellent corrosion resistance, ease of manufacture, and high thermal efficiency.Design/methodology/approachThe fluid elastic instability and vortex shedding mechanisms in a finned tube array of aluminum tubes with a base tube diameter of 19.05 mm and pitch of 34 mm were investigated. The current study considers parallel triangular finned tube arrays with fin heights of 3 mm and 6 mm with a uniform fin thickness and fin pitch. The plain tube array was tested to compare the finned tube array results. The tube vibration response was measured using an accelerometer mounted on the middle tube of the third row. In order to define the fluid elastic instability behavior of various tube arrays, the critical velocity at the instability threshold is measured. By finding the Strouhal number at the small peaks before instability, the vortex shedding behavior of the tube arrays is examined.FindingsThe results reveal that the critical velocity at instability for coarse finned tube arrays increases as the fin height increases. The effect of the tube material is evaluated by comparing the results with those previously reported for parallel triangular tube arrays made of steel. Finally, the occurrence of vortex shedding in a tube array is confirmed based on the Reynolds number and Strouhal number relationship. The instability constant K for the plain tube array of steel and aluminum material are 4.97 and 4.87, respectively.Originality/valueThis paper provides the research findings on the effect of fin height on coarse density finned tube array. This will add substantial knowledge to the literature in the field of fluid elastic instability and vortex shedding, which is needed for the safe functioning of shell and tube heat exchangers.
CEO environmentally specific transformational leadership and firm proactive environmental strategy: roles of TMT green commitment and regulative pressure
Authors: Yang Chen , Zhang Lu 
Published: September 2022

PurposeThis research aims to focus on the environmentally specific transformational leadership (ETFL) of a chief executive officer (CEO) and aims to examine the effect of CEOs' ETFL on firm's proactive environmental strategies (PESs), by indicating the top management team's (TMT) green commitment as a mediator and regulative pressure as a moderator to understand the relation.Design/methodology/approachThis study used multisource data from 170 small-to medium-sized manufacturing firms in China.FindingsThe results indicated that CEOs' ETFL was positively related to the TMT's green commitment, which, in turn, enhanced the firm's PESs. Moreover, regulative pressure strengthened the direct effect of CEOs' ETFL on their TMTs' green commitment and the indirect effect of CEOs' ETFL on the firm's PESs via TMTs' green commitment.Originality/valueThe tested importance of regulative pressure as an external condition that strengthens the effectiveness of CEOs' ETFL offers new theoretical insights to advance the literature on PESs.
Health services in Australia and the impact of antiquated rostering practices on medical scientists: a case for HR analytics and evidenced-based human resource management
Authors: Cavanagh Jillian , Bartram Timothy , Walker Matthew , Pariona-Cabrera Patricia , Halvorsen Beni 
Published: September 2022

PurposeThe purpose of this study is to examine the rostering practices and work experiences of medical scientists at four health services in the Australian public healthcare sector. There are over 16,000 medical scientists (AIHW, 2019) in Australia responsible for carrying out pathology testing to help save the lives of thousands of patients every day. However, there are systemic shortages of medical scientists largely due to erratic rostering practices and workload issues. The purpose of this paper is to integrate evidence-based human resource management (EBHRM), the LAMP model and HR analytics to enhance line manager decision-making on rostering to support the wellbeing of medical scientists.Design/methodology/approachUsing a qualitative methodological approach, the authors conducted 21 semi-structured interviews with managers/directors and nine focus groups with 53 medical scientists, making a total 74 participants from four large public hospitals in Australia.FindingsAcross four health services, manual systems of rostering and management decisions do not meet the requirements of the enterprise agreement (EA) and impact negatively on the wellbeing of medical scientists in pathology services. The authors found no evidence of the systematic approach of the organisations and line managers to implement the LAMP model to understand the root causes of rostering challenges and negative impact on employees. Moreover, there was no evidence of sophisticated use of HR analytics or EBHRM to support line managers' decision-making regarding mitigation of rostering related challenges such as absenteeism and employee turnover.Originality/valueThe authors contribute to HRM theory by integrating EBHRM, the LAMP model (Boudreau and Ramstad, 2007) and HR analytics to inform line management decision-making. The authors advance understandings of how EBHRM incorporating the LAMP model and HR analytics can provide a systematic and robust process for line managers to make informed decisions underpinned by data.
Design for manufacture and assembly (DfMA) in architectural design meetings: from a case study to knowledge-to-action framework
Authors: Laovisutthichai Vikrom , Lu Weisheng 
Published: September 2022

PurposeDesign for manufacture and assembly (DfMA) challenges architects in managing diverse knowledge across different professional domains. Little research, if any, has documented DfMA as a knowledge-intensive activity happening in real-life cases. This research aims to investigate DfMA knowledge acquisition, sharing and implementation in real-life practice and develop DfMA knowledge-to-action framework for architects.Design/methodology/approachIt does so by (1) conducting observations in design meetings, documentary analysis and interviews, (2) thematic analysis through knowledge management (KM) perspectives and (3) based on this profound understanding, enriching the prior understanding of design as a double diamond process.FindingsThrough the lens of KM, DfMA is not merely a double but multiple diamond process, involving the iteration of making absenting interdisciplinary knowledge available, deciphering tacit knowledge explicit and embedding the knowledge in a design that well considers various criteria, the downstream manufacturing, logistics and assembly in particular. To execute multi-faceted knowledge acquisitions and implementations in DfMA, architects should balance their roles as humble learners, team coordinators, creative leaders and democratic negotiators.Originality/valueThis research reveals the DfMA implementation process, activities and dilemmas from real-world design meetings. The DfMA knowledge-to-action framework developed in this study, along with practice examples and lessons learned, can facilitate architects to play new roles. Future research is recommended to fine-tune the framework by having other stakeholders’ perspectives, refining it with additional cases and developing assistive tools for designers based on the framework.
Oral mitis group streptococci: A silent majority in our oral cavity
Authors: Okahashi Nobuo , Nakata Masanobu , Kuwata Hirotaka , Kawabata Shigetada 
Published: September 2022

AbstractMembers of the oral mitis group streptococci including Streptococcus oralis, Streptococcus sanguinis, and Streptococcus gordonii are the most abundant inhabitants of human oral cavity and dental plaque, and have been implicated in infectious complications such as bacteremia and infective endocarditis. Oral mitis group streptococci are genetically close to Streptococcus pneumoniae; however, they do not produce cytolysin (pneumolysin), which is a key virulence factor of S. pneumoniae. Similar to S. pneumoniae, oral mitis group streptococci possess several cell surface proteins that bind to the cell surface components of host mammalian cells. S. sanguinis expresses long filamentous pili that bind to the matrix proteins of host cells. The cell wall–anchored nuclease of S. sanguinis contributes to the evasion of the neutrophil extracellular trap by digesting its web‐like extracellular DNA. Oral mitis group streptococci produce glucosyltransferases, which synthesize glucan (glucose polymer) from sucrose of dietary origin. Neuraminidase (NA) is a virulent factor in oral mitis group streptococci. Influenza type A virus (IAV) relies on viral NA activity to release progeny viruses from infected cells and spread the infection, and NA‐producing oral streptococci elevate the risk of IAV infection. Moreover, oral mitis group streptococci produce hydrogen peroxide (H2O2) as a by‐product of sugar metabolism. Although the concentrations of streptococcal H2O2 are low (1–2 mM), they play important roles in bacterial competition in the oral cavity and evasion of phagocytosis by host macrophages and neutrophils. In this review, we intended to describe the diverse pathogenicity of oral mitis group streptococci.
Same mesozooplankton functional groups, different functions in three Arctic marine ecosystems
Authors: Saint‐Béat Blanche , Darnis Gérald , Leclerc Maxime , Babin Marcel , Maps Frédéric 
Published: September 2022

Abstract

The trophic relationships interconnecting marine organisms together into a dynamic trophic network drive the structure and the functioning of the entire ecosystem. Since the flow of carbon within trophic networks is controlled by a variety of functional traits related to food acquisition and individual survival, it is crucial to understand how functional diversity relates to marine ecosystems properties such as the resistance and resilience against perturbations.

In the Arctic, marine ecosystems are facing stronger and faster environmental changes than anywhere on Earth, leading to profound perturbations in the planktonic assemblages at the base of the trophic networks. While it is known that mesozooplankton plays a crucial role of matter and energy hub within marine Arctic food web, the precise role of the diverse mesozooplankton functional groups in carbon circulation and in marine ecosystems functioning remains poorly known.

We coupled a trait‐based approach of mesozooplankton diversity to an ecological network analysis approach to test whether similar mesozooplankton functional groups played similar ecological roles in three Arctic ecosystems during the summer period. We formed nine mesozooplankton functional groups by gathering different species according to their feeding strategies. Then we implemented those into inverse food web models (linear inverse modelling) describing three contrasted Arctic ecosystems. In each ecosystem, we performed sensitivity analysis experiments where each mesozooplankton functional group was removed one at a time.

Our results showed that, although the same main functional groups composed the three ecosystems, the few outstanding changes observed in the carbon circulation within the food web were strongly controlled by both the initial whole‐network properties and productivity of the ecosystem.

The various roles played by a given mesozooplankton functional group in the ecosystem depend on its impact on carbon flows through the food web it belongs to. As a result, identifying which functional groups could be threatened, and which carbon flows could be altered by climate change is critical information to predict future ecosystems functioning.

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Model‐based optimization of source locations for 3D acoustic seismic full‐waveform inversion
Authors: Winner Valérie , Edme Pascal , Maurer Hansruedi 
Published: September 2022

AbstractBesides classical imaging techniques, full‐waveform inversion is an increasingly popular method to derive elastic subsurface properties from seismic data. High‐resolution velocity models can be obtained, and spatial sampling criteria are less strict than for imaging methods, because the entire information content of the seismic waveforms is used. As high operational costs arise from seismic surveys, the acquirable data volume is often limited by economic criteria. By selecting optimal locations for seismic sources, the information content of the data can be maximized, and the number of sources and thus the acquisition costs can be reduced compared with standard acquisition designs. The computation of such optimized designs for large‐size 3D inverse problems at affordable computational cost is challenging. By using a sequential receiver‐wise optimization strategy, we substantially reduce the computational requirements of the optimization process. We prove the applicability of this method by means of numerical 3D acoustic examples. Optimized source designs for different receiver patterns are computed for a realistic subsurface model, and the value of the designs is evaluated by comparing checkerboard inversion tests with different acquisition designs. Our examples show that inversion results with higher accuracy can be obtained with the optimized designs, regardless of the number of sources, the number of receivers, or the receiver distribution. Larger benefits of the optimized designs are visible when a sparse receiver geometry is used.