bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Combined Cataract Surgery on Outcomes of Descemet's Membrane Endothelial Keratoplasty: A Systematic Review and Meta-Analysis
Authors: Tey Kai Yuan , Tan Sarah Yingli , Ting Darren S. J. , Mehta Jodhbir S. , Ang Marcus 
Published: March 2022

ObjectiveA systematic review and meta-analysis of literature-to-date regarding the effects of combined cataract surgery on outcomes of DMEK.MethodsMultiple electronic databases were searched, including Cochrane Library databases, PubMed, Web of Science, and ClinicalTrials.gov. The final search was updated on 10th February 2022. We included randomized controlled trials (RCTs), non-randomized studies and large case series (≥25 eyes) of DMEK (pseudophakic/phakic) and “triple DMEK”. A total of 36 studies were included in this study. Meta-analyses were done with risk differences (RD) computed for dichotomous data and the mean difference (MD) for continuous data via random-effects model. Primary outcome measure: postoperative re-bubbling rate; secondary outcome measures: complete/partial graft detachment rate, best-corrected visual acuity (BCVA), endothelial cell loss (ECL), primary graft failure, and cystoid macular edema (CMO).ResultsA total of 11,401 eyes were included in this review. Based on non-randomized studies, triple DMEK demonstrated a better BCVA at 1-month postoperative than DMEK alone (MD 0.10 logMAR; 95% CI: 0.07–0.13; p &lt; 0.001), though not statistically significant at 3–6 months postoperative (MD 0.07 logMAR; 95% CI: −0.01 to 0.15; p = 0.08). There was no significant difference in rebubbling, ECL, graft failures, and CMO postoperatively between the two groups (p = 0.07, p = 0.40, 0.06, and 0.54 respectively).ConclusionOur review suggests that DMEK has a similar post-operative complication risk compared to “triple DMEK” (low-quality evidence), with comparable visual outcome and graft survival rate at 6 months postoperative. High-quality RCTs specifically studying the outcomes of combined vs. staged DMEK are still warranted.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020173760, identifier: CRD42020173760.
Clinical Correlation Between Overactive Bladder and Allergy in Children
Authors: Yin Lu , Zhang Zhou , Zheng Yue , Hou Ling , Zhao Cheng-Guang , Wang Xiu-Li , Jiang Kai-Lei , Du Yue 
Published: March 2022

Background:The International Children's Continence Society defines overactive bladder (OAB) as a clinical syndrome characterized by urgency of urination usually accompanied by frequent urination and nocturia symptoms. This study aims to explore the correlation between overactive bladder (OAB) and allergy in children.Method:The clinical characteristics of 918 patients diagnosed with OAB from January 2020 to March 2021 were retrospectively analyzed. Risk factors for OAB were analyzed using logistic regression analysis, and the effect of desloratadine in the treatment of OAB was evaluated.Results:The incidence of allergic cough or allergic rhinitis in the mild OAB group was higher than the moderate–severe group. Urodynamics demonstrated that the proportion of patients with a sensitive bladder in the overactive detrusor group was significantly higher than the non-overactive detrusor group. The effective rate of treatment of OAB in patients complicated with allergies and taking desloratadine was 90.14%, which was significantly higher than in patients who were not taking desloratadine, and blood IgE level was a risk factor of ineffective treatment with desloratadine.Conclusion:OAB is correlated with allergies in children, and desloratadine can effectively improve OAB symptoms.
Isolation and Characterization of Two Postsynaptic Neurotoxins From Indian Cobra (Naja Naja) Venom
Authors: Huynh Tam M. , Silva Anjana , Isbister Geoffrey K. , Hodgson Wayne C. 
Published: March 2022

The Indian Cobra (Naja naja) is among the “Big Four” responsible for most of the snakebite envenoming cases in India. Although recent proteomic studies suggest the presence of postsynaptic neurotoxins in N. naja venom, little is known about the pharmacology of these toxins. We isolated and characterized α-Elapitoxin-Nn2a (α-EPTX-Nn2a; 7020 Da) and α-Elapitoxin-Nn3a (α-EPTX-Nn3a; 7807 Da), a short-chain and long-chain postsynaptic neurotoxin, respectively, which constitute 1 and 3% of N. naja venom. α-EPTX-Nn2a (100–300 nM) and α-EPTX-Nn3a (100–300 nM) both induced concentration-dependent inhibition of indirect twitches and abolished contractile responses of tissues to exogenous acetylcholine and carbachol, in the chick biventer cervicis nerve-muscle preparation. The prior incubation of tissues with Indian polyvalent antivenom (1 ml/0.6 mg) prevented the in vitro neurotoxic effects of α-EPTX-Nn2a (100 nM) and α-EPTX-Nn3a (100 nM). The addition of Indian polyvalent antivenom (1 ml/0.6 mg), at the t90 time point, could not reverse the in vitro neurotoxicity of α-EPTX-Nn2a (100 nM). The in vitro neurotoxicity of α-EPTX-Nn3a (100 nM) was partially reversed by the addition of Indian polyvalent antivenom (1 ml/0.6 mg), as well as repeated washing of the tissue. α-EPTX-Nn2a displayed non-competitive antagonism of concentration-response curves to carbachol, with a pA2 of 8.01. In contrast, α-EPTX-Nn3a showed reversible antagonism of concentration-response curves to carbachol, with a pA2 of 8.17. De novo sequencing of α-EPTX-Nn2a and α-EPTX-Nn3a showed a short-chain and long-chain postsynaptic neurotoxin, respectively, with 62 and 71 amino acids. The important observation made in this study is that antivenom can reverse the neurotoxicity of the clinically important long-chain neurotoxin, but not the short-chain neurotoxin, from N. naja venom.
PEDAGOGICAL COACHING AS A TECHNOLOGY OF FORMATION OF DIGITAL COMPETENCE OF FUTURE TEACHERS OF MATHEMATICS
Authors: MOSKALENKO O. , PETRENKO L. 
Published: March 2022

In the article authors explain the essence of the concept of «pedagogical coaching» and consider it in the context of formation of digital competence of future teachers of mathematics as pedagogical technology.
It has been found that pedagogical coaching, as a technology for developing the digital competence of future teachers of mathematics, is a useful technique for organizing and educating students through the use of digital and information resources, based on a resource-oriented approach and aiming at the creation of optimal conditions for developing the potential of the personality of students, thus ensuring the training of the ability to act and learn effectively and the development of skills for independent cognitive search, effective management of their own training activities. The stages of the coach sessions are highlighted and described: analytical-preparatory, operational-efficient and reflexive-result.
MAIN DIRECTIONS OF SPIRITUAL AND MORAL EDUCATION OF CHILDREN IN PRESCHOOL EDUCATION INSTITUTIONS
Authors: PETRENKO L. 
Published: March 2022

The basic ideas of education of spirituality and morality in folk pedagogy and ethno pedagogy are revealed. The views of prominent Ukrainian teachers on the spiritual and moral education of preschool children are analyzed. The influence of Christian traditions on the spiritual and moral development of the individual is clarified. The leading components of spiritual and moral education are highlighted. Forms of work with children in preschool education institutions are covered, directions of spiritual and moral education are determined. The relevance of spiritual and moral education of preschool children is substantiated.
The instability of the spiritual and moral atmosphere in society has caused a particularly acute problem of spiritual values formation and moral priorities in the life of the child. The concepts of sensitivity, mercy, compassion, empathy, conscience, the need to act well should be a key guideline in the implementation of a spiritual life-affirming model of personality. The study found that in folk pedagogy were common areas of spiritual and moral education of children: household, customary, civic education. Spiritual and moral education of preschool children by the legacy of prominent teachers of the first third of the twentieth century was carried out in the following areas: national education; family upbringing; religious education; mental education; aesthetic education). Spiritual and moral education of preschool children at the present stage is a priority for the harmonious development of personality. The upbringing of children is based on a certain system of values such as: universal, national and civic. It is carried out in the following areas: national-patriotic, civic education; family upbringing; labor education; aesthetic education; environmental education.
Pemanfaatan Limbah Media Jamur Merang sebagai Pupuk Organik Tanaman Kangkung Darat (Impomea reptansPoir) untuk Mendukung Pertanian Berkelanjutan
Authors: Wahana Siti , Herista Mutia Intan Savitri , Saleh Ismail 
Published: March 2022

Aim from this research is to know about affect dosage of mushroom fertilizer to growht of kale land. The use of compost in planting kale land is one of the efforts to support sustainable agriculture. This research conduct in Trial Garden Gedung Tambahan Agriculture Faculty of Universitas Swadaya Gunung Jati. This reasearch conduct in Mei – July 2020. This research used Completely Randomized Design consisting of one factor. The factor is compost dosage with five treatment. There is 0 fertilizer : 4 soil, 1 fertilizer : 3 soil, 2 fertilizer : 4 soil, 3 fertilizer : 1 soil and 4 fertilizer : 0 soil. Every treatment repeat three times. The results showed that the difference in compost dosage significantly affected all growth vegetative parameters measured. The dose of K3 compost (3 compost: 1 soil) is the most optimal for the vegetative growth of kale. dry weight the most appropriate dose is K4 compost (4 Compost : 0 soil).
CONSTRUCCIÓN DE LA TRAMA Y URDIMBRE DE UNA CIUDAD EN EL SIGLO XVI: SANTA MARÍA DE LA ASUNCIÓN MISANTLA, VERACRUZ, MÉXICO
Authors: Ruiz Gordillo Javier Omar 
Published: March 2022

Santa María de la Asunción Misantla surge de la congregación de varios pueblos indígenas de la sierra de Chiconquiaco en el Estado de Veracruz, México, durante las primeras décadas del siglo XVI, siguiendo el modelo que había aplicado Fray Nicolás de Ovando en Santo Domingo en 1502, Hernán Cortés en la Veracruz en 1524, y que Felipe II autorizaría su publicación, parcial, en 1573 del libro II de las Ordenanzas de descubrimientos, nueva población y pacificación de las Indias y publicadas en su totalidad hasta el 3 de mayo de 1576 para reordenar las nuevas fundaciones pero, en el fondo para proveer a la Nueva España de una organización política y administrativa.
¿Qué tiene, entonces, de particular esta ciudad? La trama y urdimbre del urbanismo de Misantla refleja no únicamente el acatamiento de tales ordenanzas, aún no escritas, pero ya impulsadas en la práctica de anteriores asentamientos como la misma ciudad de México en 1524 o la de Puebla, en 1531; sin embargo, en esta Misantla de 1531 los indígenas repiten un patrón de composición de pueblos reflejando su conocimiento del mundo repartido en cuatro rumbos o cuarteles.
Si bien, los indígenas totonacos abandonaron sus pueblos y fueron reubicados entre 1531 y 1564, el urbanismo es una clara representación del mundo en cuatro lados y el centro del universo u ombligo al cual consideraban el centro del cosmos, esquema que se advierte en el urbanismo de múltiples pueblos prehispánicos como Tenochtitlan o Teotihuacan y sigue repitiéndose en algunas poblaciones, entre ellas en Zinacantán, al sur de México, en el Estado de Chiapas, o al norte, entre los huicholes, tanto en sus milpas como en las obras de arte.
ANALISIS YURIDIS PEMENUHAN HAK PEKERJA YANG DIRUMAHKAN PERUSAHAAN TERDAMPAK PANDEMI COVID-19 DI KOTA SURABAYA
Authors: Reka Mutia , Rezanti Benita Dita , Sulistiyantoro Haryo 
Published: March 2022

Pandemi COVID-19 yang merebak di Indonesia dari Maret 2020 membawa dampak menyusahkan, misal pada bidang ketenagakerjaan, dimana perusahaan yang merugi karena permintaan berkurang, beberapa perusahaan di Surabaya akhirnya merumahkan pekerja, dengan dalih dipanggil lagi perusahaan saat membutuhkan, namun disini hak normatif pekerja sering diabaikan, padahal mereka, pekerja yang dirumahkan saat pandemi COVID-19 dimuat dalam Surat Edaran Menteri Ketegakerjaan Republik Indonesia Nomor M/3/HK.04/III/2020 tentang Perlindungan Pekerja/Buruh dan Kelangsungan Usaha Dalam Pencegahan dan Penanggulangan COVID-19, namun terdapat aturan lebih jelas yang mengaturnya. Pada penelitian ini berfokus pada analisa secara perundang-undangan pekerja yang dirumahkan, lalu analisa pada pemenuhan hak pekerja yang dirumahkan baik itu akibat hukumnya maupun hak normatifnya. Pada penelitian ini memakai metode penelitian yuridis normatif, dimana permasalahan yang dibahas penulis yakni pemenuhan hak pekerja yang dirumahkan karena pandemi COVID-19 akan dianalisa dengan pendekatan perundang-undangan dan teoritis, penelitian ini didukung dengan data sekunder dan primer yang diperoleh penulis. Hasil Penelitian ini dapat disimpulkan bahwasanya tindakan merumahkan pekerja memang bisa dilakukan mengingat kondisi perusahaan tidak memungkinkan untuk mempekerjakannya, namun sebisa mungkin dihindari oleh perusahaan karena mengandung akibat hukum, dan jika terpaksa merumahkan pekerja perusahaan terdapat hak dan kewajiban seperti upah penuh yang wajib dibayarkan sesuai perundang-undangan ataupun apabila ada kesepakatan lain.Kata Kunci: Pandemi COVID-19, Hak Pekerja, Dirumahkan
Pedagogika pastiszu – co spodobałoby się Ignacemu Loyoli w Nowych wierszach sławnych poetów Grzegorza Uzdańskiego?
Authors: Telicki Marcin 
Published: March 2022

CEL NAUKOWY: Artykuł Pedagogika pastiszu - co spodobałoby się Ignacemu Loyoli w „Nowych wierszach sławnych poetów” Grzegorza Uzdańskiego ma na celu podjęcie refleksji nad literacką stylizacją, której funkcja nie jest parodystyczna, lecz krytyczna.
PROBLEM I METODY BADAWCZE: Autor dokonuje analizy współczesnego pastiszu, umieszczonego w teoretycznej ramie metamodernizmu (przeciwstawianego formom postmodernistycznym). Drugim problemem badawczym jest możliwość przeprowadzenia analogii między dociekaniami literaturoznawczymi a ustaleniami pedagogiki ignacjańskiej. W związku z tym analizy i interpretacje prowadzone są hermeneutyczną metodą close-reading (w części interpretacyjnej) oraz metodami komparatystycznymi (w partiach teoretycznych).
PROCES WYWODU: Praca została podzielona na pięć części. Po wprowadzeniu następuje część teoretyczna zawierająca opis przemian kulturowych we współczesnym świecie (w tym próbę diagnozy sytuacji po postmodernizmie). Następnie autor dokonuje interpretacji wybranych wierszy Grzegorza Uzdańskiego. Stają się one przyczynkiem do rozważań o poszukiwaniu podmiotowości, tożsamości, rozumienia przeszłości czy sposobów radzenia sobie z kryzysem, które okazują się zaskakująco podobne do metod proponowanych w szkole Ignacego z Loyoli (próba poprowadzenia takiej paraleli znajduje się w czwartej części tekstu). Całość zamykają konkluzje i zarysowanie perspektywy dalszych badań.
WYNIKI ANALIZY NAUKOWEJ: Autor pokazuje, w jaki sposób współczesna poezja wprowadza reprezentacje przemian kulturowych zachodzących pod wpływem mediów (na obecnym etapie możliwych do powiązania z metamodernizmem). Znajduje także punkty wspólne między poznawczo-wychowawczymi celami pastiszu a holistycznym nastawieniem duchowości i pedagogiki ignacjańskiej.
WNIOSKI, INNOWACJE, REKOMENDACJE: Zestawienie – wyłącznie częściowe z powodu braku wspólnej płaszczyzny religijno-duchowej – pokazuje możliwości niemetafizycznej lektury tekstów świeckich, które w „strukturze wrażliwości” przypominają poszukiwania duchowe.
Detection of network intelligence features with the decision tree model
Authors: Sharaev N. P. , Petrov S. N. 
Published: March 2022

O b j e c t i v e s . Early detection of network intelligence allows to reduce the risks of information security of organizations. The study was carried out to develop software module for detecting the features of network intelligence by machine learning methods.M e t h o d s . Analysis of open datasets of appropriate destination; formation of metrics characteristic of network intelligence; development of a dataset based on certain metrics; study of the effectiveness of machine learning methods for classification task.R e s u l t s . The topology was designed and a test segment was created in the corporate network of RUE "Beltelecom" to create a dataset. A monitoring tool has been developed for detecting and analyzing the events, the results of which were used as the basis for a new dataset.The implementation of the decision tree method in the form of program code allowed to increase the speed of the module by about 2 times (0,147 ms). Practical tests of the developed module have shown the alarm on all types of network scanning using Nmap and Masscan utilities.Co n c l u s i o n. The analysis of the dataset by principal component method showed the presence of a border area between the events of legal traffic and network intelligence traffic, which had a positive effect on the training of the model. The most promising machine learning methods have been studied and tested using various hyperparameters. The best results were shown by the decision tree method with the parameters criterion = gini and splitter = random and speed as 0,333 ms.
Comments on “Predicativity as a philosophical position” by G. Hellman
Authors: Feferman Solomon 
Published: March 2022

Geoffrey Hellman afinement critique les fondement philosophiques de la predicativite sous differents angles. Ceci est une reponse point par pointfaite a partir d'une position de sympathie - mais non d'identification — avec le predicativisme sur la base d'un anti-platonismepartage, appuyee sur I 'experience d'une recherche approfondie sur sa portee et ses limites logiques et mathematiques. Pour ce qui est des suggestions finales de Hellman - contre une telle position limitative - sur le role explicatif unificateur possible des axiomes de grands cardinaux en theorie des ensembles, il se pent bien qu 'il n 'y ait pas de limite philosophique ou mathematique naturelle a ce qui est exigible pour les « mathematiques authentiques » ; la predicativite nefournit certes pas une telle limite. Mais les exemples discutes de programmes visant a demontrer la necessite de grands cardinaux nous obligent, en tant que philosophes, a examiner la question : qu'est-ce qui compte, exactement, comme « mathematiques authentiques », et pourquoi ?
Les masses : révolte, triomphe et échec
Authors: Sánchez Cámara Ignacio 
Published: March 2022

La Révolte des masses de José Ortega y Gasset est l’un des diagnostics les plus lucides de la crise morale européenne. Cette crise est la conséquence de l’apparition d’un nouveau genre humain : l’homme-masse révolté. La révolte annoncée a été une victoire, mais ce triomphe signe aussi son échec. La solution de la crise ne peut provenir que d’une réforme radicale de la philosophie, qui dépasserait le subjectivisme et le relativisme auxquels nous a conduits l’évolution égarée de la modernité. L’essai d’Ortega y Gasset est d’une actualité remarquable qui permet de comprendre la situation spirituelle de notre époque.
Surveillance system-based physician reporting of pneumonia of unknown etiology in China
Authors: Du Hongchun , Zhu Yajuan , Chen Yan , Zhou Shidan , Tong Jiani , Deng Yingnan , Zhang Dingmei 
Published: March 2022

Objective:
To describe the current reporting of pneumonia of unknown etiology (PUE) and factors that affect reporting by clinicians in China using the PUE surveillance system in order to provide a reference for improving PUE reporting rates in the future.

Methods:
Clinicians were recruited via the Sojump platform and requested to complete an anonymous self-administered questionnaire. Multivariate logistic regression analysis was used to assess factors influencing clinicians’ reporting activities.

Results:
This study showed a low PUE case reporting rate and a poor understanding of PUE reporting among the investigated clinicians. Of the 136 clinicians who had diagnosed PUE cases, multivariate logistic regression analysis results showed that clinicians who had attended in-hospital training were more likely to report PUE than those who had not (OR 4.48, 95% CI 1.49-13.46). Clinicians with an expert panel on PUE in their hospital were more likely to report PUE cases than those without (OR 5.46, 95% CI 1.85-16.11).

Conclusions:
There is a need to promote and reinforce PUE surveillance system training among medical staff. In addition, PUE testing technologies in hospital laboratories should be upgraded, especially in primary and unclassified hospitals, to increase surveillance efficiency and improve PUE reporting rates.
Potential Use of Immature Oocyte to Improve Fertility Preservation Outcome
Authors: Sirait Batara , Jusuf Ahmad Aulia , Wiweko Budi , Handayani Nining , Aubry Daniel Abidin , Muharam R. 
Published: March 2022

ABSTRACT
Fertility preservation through gamete vitrification has become one of the critical strategies to secure a childbearing potential in patients who are diagnosed with cancer or risks of infertility. Preserving the gametes would prevent the deleterious effects of cancer drugs or radiotherapy exposure on the quality of the gametes. Furthermore, in vitro fertilisation of vitrified mature human oocytes has lately demonstrated promising results that are reflected in the increased survival rate of thawed oocytes and the resultant clinical pregnancy rate. However, limitations in the cryopreservation of mature oocytes of cancer patients persist. Ovarian stimulation protocols which comprise administering gonadotrophin-releasing hormones could aggravate cancer or delay essential cancer therapy. Considering such circumstances, vitrification of immature oocytes would become a rational option. While the vitrification procedure of mature oocytes has been established, the vitrification of immature oocytes remains controversial due to a low post-thaw in vitro maturation and fertilisation rate. Apparent cryoinjuries to the immature oocytes post thawing or warming have been observed in both human and animal model oocytes. An alternative strategy was therefore proposed to improve the effectiveness of utilising immature oocytes for fertility preservation by conducting the in vitro oocyte maturation process first before vitrification. This method has prevailed, especially in oncofertility patients. Although the success rate of the clinical outcomes remains low, this approach, in conjugation with proper counselling, might provide oncofertility patients with an opportunity to preserve their reproductive potential.