bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of abortion after frozen-thawed embryo transfer in women with polycystic ovary syndrome phenotypes A and D
Authors: Wang Qiumin , Zheng Yanjun , Li Ping , Zhang Guanqun , Gao Shanshan , Wang Ze , Hao Baozhen , Shi Yuhua 
Published: September 2022

AbstractPolycystic ovary syndrome (PCOS) is associated with adverse pregnancy outcomes, including an increased risk of abortion, premature delivery, and even neonatal outcomes. After removing the effect of COH on patients, studying the pregnancy outcomes of patients with different PCOS phenotypes after FET may better reflect the impact of different PCOS phenotypes on ART outcomes. Data of 8903 patients who underwent FET between January 2017 and October 2019 were retrospectively collected and evaluated. All patients were divided into a control group and four phenotype groups based on Rotterdam criteria. The main outcomes were pregnancy outcomes after FET. We found significantly higher abortion (P = 0.010) and lower ongoing pregnancy (P = 0.023) rates for women with PCOS phenotypes A and D compared to those in the control group. After adjusting for potential confounders, PCOS phenotypes A and D were associated with an elevated risk of abortion (adjusted OR, 1.476, P = 0.016; adjusted OR, 1.348, P = 0.008, respectively). The results of this study suggest that when performing FET, clinicians should individually manage women with PCOS phenotypes A and D to reduce the rate of abortion and increase the rate of LB, and achieve better pregnancy outcomes.
Predicting the effects of climate change on the cross-scale epidemiological dynamics of a fungal plant pathogen
Authors: Miller Ian F. , Jiranek Juliana , Brownell Mckenna , Coffey Sarah , Gray Barrett , Stahl Maria , Metcalf C. Jessica E. 
Published: September 2022

AbstractThe potential for climate change to exacerbate the burden of human infectious diseases is increasingly recognized, but its effects on infectious diseases of plants have received less attention. Understanding the impacts of climate on the epidemiological dynamics of plant pathogens is imperative, as these organisms play central roles in natural ecosystems and also pose a serious threat to agricultural production and food security. We use the fungal ‘flax rust’ pathogen (Melampsora lini) and its subalpine wildflower host Lewis flax (Linum lewisii) to investigate how climate change might affect the dynamics of fungal plant pathogen epidemics using a combination of empirical and modeling approaches. Our results suggest that climate change will initially slow transmission at both the within- and between-host scales. However, moderate resurgences in disease spread are predicted as warming progresses, especially if the rate of greenhouse gas emissions continues to increase at its current pace. These findings represent an important step towards building a holistic understanding of climate effects on plant infectious disease that encompasses demographic, epidemiological, and evolutionary processes. A core result is that neglecting processes at any one scale of plant pathogen transmission may bias projections of climate effects, as climate drivers have variable and cascading impacts on processes underlying transmission that occur at different scales.
Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition
Authors: Ruiz-Mitjana Anna , Navaridas Raúl , Vidal-Sabanés Maria , Perramon-Güell Aida , Yeramian Andree , Felip Isidre , Eritja Núria , Egea Joaquim , Encinas Mario , Matias-Guiu Xavier , Dolcet Xavier 
Published: September 2022

AbstractThe extracellular matrix and the correct establishment of epithelial cell polarity plays a critical role in epithelial cell homeostasis and cell polarity. In addition, loss of tissue structure is a hallmark of carcinogenesis. In this study, we have addressed the role of extracellular matrix in the cellular responses to TGF-β. It is well known that TGF-β is a double-edged sword: it acts as a tumor suppressor in normal epithelial cells, but conversely has tumor-promoting effects in tumoral cells. However, the factors that determine cellular outcome in response to TGF-β remain controversial. Here, we have demonstrated that the lack of extracellular matrix and consequent loss of cell polarity inhibits TGF-β-induced apoptosis, observed when endometrial epithelial cells are polarized in presence of extracellular matrix. Rather, in absence of extracellular matrix, TGF-β-treated endometrial epithelial cells display features of epithelial-to-mesenchymal transition. We have also investigated the molecular mechanism of such a switch in cellular response. On the one hand, we found that the lack of Matrigel results in increased AKT signaling which is sufficient to inhibit TGF-β-induced apoptosis. On the other hand, we demonstrate that TGF-β-induced epithelial-to-mesenchymal transition requires ERK and SMAD2/3 activation. In summary, we demonstrate that loss of cell polarity changes the pro-apoptotic function of TGF-β to tumor-associated phenotype such as epithelial-to-mesenchymal transition. These results may be important for understanding the dual role of TGF-β in normal versus tumoral cells.
HSP expression depends on its molecular construction and different organs of the chicken: a meta-analysis
Authors: Siddiqui Sharif Hasan , Khan Mousumee , Choe Hosung , Kang Darae , Shim Kwanseob 
Published: September 2022

AbstractHeat shock proteins (HSPs) expression protect the cell from stress, this expression varies on tissue and stress level. Here, we investigated the structure and functional expression of HSPs in different chicken organs using meta-analysis. A total of 1253 studies were collected from three different electronic databases from January 1, 2015 to February 1, 2022. Of these studies, 28 were selected based on the specific criteria for this meta-analysis. The results for the expression of HSPs and the comparative expression of HSPs (HSP90, HSP70, and HSP60) in different chicken organs (brain, heart, liver, muscle, and intestine) were analyzed using the odds ratio or the random-effects model (REM) at a confidence interval (CI) of 95%. Compared to the thermoneutral groups, heat stress groups exhibited a significant (P < 0.01) change in their HSP70 expression in the chicken liver (8 trials: REM = 1.41, 95% CI: 0.41, 4.82). The expression of different HSPs in various chicken organs varied and the different organs were categorized according to their expression levels. HSP expression differed among the heart, liver, and muscle of chickens. HSPs expression level depends on the structure and molecular weight of the HSPs, as well as the type of tissue.
Effect of louver baffles installation on hydrodynamics of bubbling fluidization in biomass gasifier
Authors: Phuakpunk Kiattikhoon , Chalermsinsuwan Benjapon , Assabumrungrat Suttichai 
Published: September 2022

AbstractBiomass gasification by a bubbling bed gasifier has been a promising process to produce fuels from biomass. However, the performance is limited by gas aggregation in the gasifier. In this study, CFD simulations were used to investigate hydrodynamics in bubbling bed gasifiers installed with multilayer louver baffles to understand the roles of baffles on different aspects including gas aggregation, biomass-bed mixing, gas-biomass contact, and pressure drop. The designed baffles could reduce the gas aggregation particularly when the biomass is fed at the middle of the baffle zone. The baffles could enhance the biomass-bed mixing and the gas-biomass contact throughout the bed except near the biomass inlet. The installation of baffles would not significantly affect the overall pressure drop but slightly affect at the mid-level of the bed. For the system in this study, the baffled gasifier with biomass feeding at the middle of the baffled zone and the gas inlet velocity of 0.7 m/s could provide the best performance in term of hydrodynamics.
Metabolic profiling of Lantana camara L. using UPLC-MS/MS and revealing its inflammation-related targets using network pharmacology-based and molecular docking analyses
Authors: El-Banna Alaa A. , Darwish Reham S. , Ghareeb Doaa A. , Yassin Abdelrahman M. , Abdulmalek Shaymaa A. , Dawood Hend M. 
Published: September 2022

AbstractLantana camara L. is widely used in folk medicine for alleviation of inflammatory disorders, but studies that proved this folk use and that revealed the molecular mechanism of action in inflammation mitigation are not enough. Therefore, this study aimed to identify L. camara phytoconstituents using UPLC-MS/MS and explain their multi-level mechanism of action in inflammation alleviation using network pharmacology analysis together with molecular docking and in vitro testing. Fifty-seven phytoconstituents were identified in L. camara extract, from which the top hit compounds related to inflammation were ferulic acid, catechin gallate, myricetin and iso-ferulic acid. Whereas the most enriched inflammation related genes were PRKCA, RELA, IL2, MAPK 14 and FOS. Furthermore, the most enriched inflammation-related pathways were PI3K-Akt and MAPK signaling pathways. Molecular docking revealed that catechin gallate possessed the lowest binding energy against PRKCA, RELA and IL2, while myricetin had the most stabilized interaction against MAPK14 and FOS. In vitro cytotoxicity and anti-inflammatory testing indicated that L. camara extract is safer than piroxicam and has a strong anti-inflammatory activity comparable to it. This study is a first step in proving the folk uses of L. camara in palliating inflammatory ailments and institutes the groundwork for future clinical studies.
Antioxidant, cytotoxic, and antibacterial activities of Clitoria ternatea flower extracts and anthocyanin-rich fraction
Authors: Jeyaraj Ethel Jeyaseela , Lim Yau Yan , Choo Wee Sim 
Published: September 2022

AbstractClitoria ternateaflower is a traditional medicinal herb that has been used as a natural food colourant. As there are limited studies on investigating the bioactivities of the anthocyanin-rich fraction ofClitoria ternateaflower, this study aimed to determine an efficient column chromatography method to obtain the anthocyanin-rich fraction from this flower and characterise its composition, antioxidant, antibacterial, and cytotoxic activities. Amberlite XAD-16 column chromatography was more efficient in enriching the total anthocyanin content (TAC) of the fraction with the highest TAC to total phenolic content (TPC) ratio of 1:6 than that using C18-OPN. A total of 11 ternatin anthocyanins were characterised in the anthocyanin-rich fraction by LC–MS analysis. The antioxidant activity of the anthocyanin-rich fraction was more potent in the chemical-based assay with an IC50value of 0.86 ± 0.07 mg/mL using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay than cellular antioxidant assay using RAW 264.7 macrophages. In vitro cytotoxicity assay using human embryonic kidney HEK-293 cell line showed the anthocyanin-rich fraction to be more toxic than the crude extracts. The anthocyanin-rich fraction had more potent antibacterial activity than the crude extracts againstBacillus cereus,Bacillus subtilis, andEscherichia coli. The anthocyanin-rich fraction ofC. ternateahas the potential to be used and developed as a functional food ingredient or nutraceutical agent.
The mediating role of controllability appraisals and coping strategies on adaptive functioning after job loss: a path model
Authors: Socastro Angela , Contreras Alba , Peinado Vanesa , Trucharte Almudena , Valiente Carmen , Vazquez Carmelo , Sanchez-Lopez Alvaro 
Published: September 2022

AbstractJob loss is a stressful event that increases the risk of experiencing depression and anxiety, especially during the initial months of unemployment. This study examined differences in psychological symptoms and resilient functioning accounted by employment status. The results pointed out that recently unemployed compared to currently employed individuals had lower levels of perceived controllability and resilience as well as higher levels of depression and anxiety. Path analyses showed that lower controllability appraisals at wave 1 of recently unemployed compared to employed individuals, in turn, predicted a lower use of active coping and reappraisal at wave 2, with the latter further accounting for lower levels in resilience. Higher use of distraction further mediated the relation between employment status and higher levels of depression and anxiety symptoms. Our findings demonstrate the importance of controllability appraisals and coping strategies used to promote adaptive psychological functioning following job loss.
Visualizing localized, radiative defects in GaAs solar cells
Authors: Hamadani Behrang H. , Stevens Margaret A. , Conrad Brianna , Lumb Matthew P. , Schmieder Kenneth J. 
Published: September 2022

AbstractWe have used a calibrated, wide-field hyperspectral imaging instrument to obtain absolute spectrally and spatially resolved photoluminescence images in high growth-rate, rear-junction GaAs solar cells from 300 to 77 K. At the site of some localized defects scattered throughout the active layer, we report a novel, double-peak luminescence emission with maximum peak energies corresponding to both the main band-to-band transition and a band-to-impurity optical transition below the band gap energy. Temperature-dependent imaging reveals that the evolution of the peak intensity and energy agrees well with a model of free-to-bound recombination with a deep impurity center, likely a gallium antisite defect. We also analyzed the temperature dependence of the band-to-band transition within the context of an analytical model of photoluminescence and discuss the agreement between the modeling results and external device parameters such as the open circuit voltage of the solar cells over this broad temperature range.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria
Authors: Medugu Nubwa , Aworh Mabel Kamweli , Iregbu Kenneth , Nwajiobi-Princewill Philip , Abdulraheem Khadija , Hull Dawn M. , Harden Lyndy , Singh Pallavi , Obaro Stephen , Egwuenu Abiodun , Thakur Siddhartha 
Published: September 2022

AbstractInfections caused by multi-drug resistant Escherichia coli cause significant morbidity and mortality especially in developing countries. In this study, we describe the molecular characteristics of E. coli isolated from clinical specimens and the patients’ outcomes. Phenotypic methods were used in the identification and antimicrobial susceptibility testing of E. coli from clinical specimens from a tertiary hospital in Abuja, Nigeria. Whole genome sequencing was used to describe the antimicrobial resistance genes, serotypes, sequence types/clonal complexes, and mobile genetic elements. The mean age of the patients was 20.3 years with 70.1% females and majority of isolates 75% from urine, 21% from blood cultures, and 3% each from cerebrospinal fluid and endo-cervical swabs. Of the 107 non-duplicate E. coli isolates, 101 (94.3%) were resistant to ampicillin, 95 (88.8%) to trimethoprim/sulfamethoxazole, 86 (80.4%) to ceftriaxone, 60 (56.1%) to gentamicin, and eight (7.5%) to meropenem. There were 102 (95.3%) isolates that were multi-drug resistant (MDR). Expression of Extended Spectrum Beta Lactamase (ESBL) phenotype was detected in 54 (50%) and blaCTX-M-15 genes detected in 75 (70.1%) isolates. The carbapenemase genes blaNDM-1 and blaNDM-5 were detected in six (5.6%), while the AmpC gene- blaCMY-2, was detected in seven (6.5%) isolates. Two (1.9%) isolates simultaneously harboured the blaOXA-1, blaCMY-2, blaCTX-M-15, and blaNDM-5 genes. In total, 35 sequence types (STs) were found with the majority being ST131 (n = 23; 21.5%). The most common serotype was O25:H4 associated with all 23 strains of ST131, followed by O1:H6/ST648 (n = 6). The ST410, ST671, and ST101 strains displayed phenotypic resistance to wide array of antibiotic classes and harbored high numbers of antibiotic resistance genes via in-silico analysis. The ST410 strain in particular harbored a higher number of antibiotic resistance genes and was phenotypically resistant to a wider array of antibiotics. Four pairs of isolates were closely related with three isolates (ST131, ST38, ST652) having a pairwise SNP difference of zero. 71/72 75/76 52/14. The MDR E. coli lineages circulating in this setting pose a clinical and public health threat as they can hinder effective prevention and management of infections. The genetic diversity and MDR E. coli with the emergence of ST410 and ST101 clones is concerning because of the potential for rapid dissemination in hospitals and communities- further increasing the problems of antibiotic resistance. Continuous routine surveillance of E. coli infections for AMR in hospitals becomes imperative, aimed at development of effective antimicrobial stewardship programs, facilitating prudent use of antimicrobial agents, and limiting dissemination of resistant strains.
Low dose aspirin associated with greater bone mineral density in older adults
Authors: Liu Hongzhan , Xiao Xungang , Shi Qiaojing , Tang Xianzhe , Tian Yun 
Published: September 2022

AbstractThe use of low-dose aspirin in older adults is increasing as is the prevalence of osteoporosis. Aspirin has been shown in numerous studies to affect bone metabolism. However, there is no clear link between low-dose aspirin use and bone mineral density (BMD). This study examined differences in bone mineral density between low-dose aspirin users and non-aspirin users in adults aged 50–80 years. We conducted a cross-sectional study of 15,560 participants who participated in the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020. We used a multivariate logistic regression model to evaluate the relationship between low-dose aspirin and femoral neck BMD, femoral total BMD, intertrochanteric BMD, and the first lumbar vertebra BMD (L1 BMD) in patients aged 50 to 80 years. A total of 1208 (Group 1: femoral neck BMD, total femur BMD, and intertrochanter BMD) and 1228 (Group 2: L1 BMD) adults were included in this study. In both group 1 and group 2, BMD was higher in the low-dose aspirin group than in the non-aspirin group (Total femur BMD β = 0.019, 95% CI 0.004–0.034; Femoral neck BMD β = 0.017, 95% CI 0.002–0.032; Intertrochanter BMD β = 0.025, 95% CI 0.007–0.043; L1 BMD β = 0.026, 95% CI 0.006–0.046). In subgroup analyses stratified by gender, this positive association existed in both gender after adjusting for confounders. On subgroup analyses stratified by age, this positive association existed in three different age groups after adjusting for confounders. To test whether the effect of low-dose aspirin on BMD was affected by gender and age, the interaction P value was greater than 0.05. These findings from a human study looking into the relationship between low-dose aspirin use and BMD suggest that regular low-dose aspirin may be associated with a higher BMD. The association between low-dose aspirin and BMD did not differ by age group or gender.
Preoperative albumin–bilirubin score as a prognostic indicator in patients with stage III colon cancer
Authors: Lee Hyun Gu , Lim Seok-Byung , Lee Jong Lyul , Kim Chan Wook , Yoon Yong Sik , Park In Ja , Kim Jin Cheon 
Published: September 2022

AbstractThe albumin–bilirubin (ALBI) score was created to assess the severity of liver dysfunction and to predict prognosis of hepatocellular carcinoma. Purpose of this study was to investigate the prognostic value of the ALBI score in patients with stage III colon cancer using propensity score matching (PSM) analysis. This study analyzed 510 patients with stage III colon cancer who had surgery between 2014 and 2015. The ALBI score was calculated as follows: (log10 bilirubin (μmol/L) $$\times$$
×
0.66) + (albumin (g/L) $$\times$$
×
−0.0852), and the optimal cut-off value was determined using a receiver operating characteristic analysis and the Youden Index. According to the calculated cut-off value, patients were divided into two groups: Group A (ALBI ≤  − 2.54) and Group B (ALBI >  − 2.54). The average ALBI score was − 2.68 (from − 3.39 to − 0.69). Group A had a significantly higher 5-year disease-free survival rate (85.5% vs 75.7%, p = 0.02), 5-year cancer-specific survival rate (93.7% vs 84.4%, p = 0.02), and 5-year overall survival rate (90.6% vs 77.4%, p = 0.01) than Group B. High ALBI scores were found to be an independent risk factor for both disease-free survival (HR 1.68, p = 0.048) and cancer-specific survival (HR 2.24, p = 0.028). The preoperative ALBI score was found to be a promising prognostic indicator for predicting recurrence and survival in patients with stage III colon cancer in this study. Because the ALBI score is simple and inexpensive to obtain, it has the potential to be a useful clinical marker for colon cancer patients.
Mass oscillations and matter wave’s phase and amplitude modulations of relativistic quantum particles induced by Heisenberg’s uncertainty principle
Authors: Tang Jau , Tang Qiang , Hu Z. B. 
Published: September 2022

AbstractWe present a flip-flop dual-component model to treat quantum dynamics of relativistic particles with a rest mass and investigate the matter waves’ phase and amplitude modulations due to Heisenberg’s uncertainty principle. Their matter waves behave like a traveling Gaussian-shaped wave packet accompanied by a guiding pilot wave, and the phase modulations result in mass oscillations. These effects are more prominent for light-weighted elementary particles, such as neutrinos and electrons. This mechanism is solely due to the uncertainty principle and has nothing to do with the flavor-mixing of neutrinos. Simulations using neutrinos and electrons are presented, which indicate an oscillation period on the order of ps. This study primarily focuses on the predicted mass oscillations induced by the uncertainty principle. A slit-type interference experiment using neutrinos and electrons from reactors is proposed to test the predicted behaviors.
Health Behavior and Motivational Engagement Models Can Explain and Modify Teleaudiology Uptake
Authors: Abrams Harvey B. , Callahan Christina 
Published: September 2022

Purpose:
The remote delivery of health care services (i.e., telehealth) has steadily increased across the health care landscape over the past decade with a dramatic increase following the onset of the COVID-19 pandemic. Remote audiology delivery (i.e., teleaudiology), by contrast, has traditionally been characterized by relatively low utilization. While teleaudiology services increased during the COVID-19 lockdown period, most of those services were generally limited to follow-up care and postfitting consultations to existing patients. Furthermore, there is reason to believe that, despite the benefits that remote care provides, the use of teleaudiology services has decreased as in-person care has increased following the lifting of mandatory COVID-related lockdowns. The purpose of this viewpoint article is to posit that existing theories of health behavior, usually applied to patient-specific behaviors (e.g., hearing aid uptake) may explain the reluctance of audiologists to “uptake” a teleaudiology model of care. We also explore the potential of motivational engagement strategies as a means to allow audiologists to examine their sources of ambivalence as they consider adopting a remote service-delivery model.

Conclusions:
Health behavior models such as the Health Belief, Transtheoretical, and capability, opportunity, motivation, and behavior (COM-B) models represent theories that may help to explain audiologists' resistance to adopting remote delivery services. Motivational engagement strategies, such as decisional balance, can provide useful tools for audiologists to examine their attitudes toward the adoption of teleaudiology.