bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problematic questions in the development of specific prevention of dengue fever
Authors: Kazachinskaia E. I. , Shanshin D. V. , Scherbakov D. N. , Shestopalov A. M. 
Published: March 2022

Dengue fever known from literary sources since the Qin dynasty (265-420) is caused in humans when bitten by Aedes mosquitoes infected with the dengue virus (DENV) and manifests as a flu-like disease. A feverish state can be accompanied by dyspeptic disorders (nausea, vomiting, diarrhea) and a rash. Approximately 1-2% of infections are clinically presented as the most severe form – it is dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) leading to 500 thousand annual hospitalizations with a mortality rate of about 5% in endemic areas.Four genetically removed DENV serotypes (1, 2, 3, and 4) are classified as different types of viruses within the same antigen complex and have almost identical epidemiological features. In 2013 a new serotype DENV-5 was isolated.Until the 1980s in most geographical regions of the world where dengue fever was registered only one or two viral serotypes were detected as an etiological agent of the disease. Over time there is an increase in the cocirculation of four types of viruses which can serve as a key indicator of their global spread. As the “traces” of the four DENV species overlap more and more the threat of severe disease increases due to the phenomenon of antibody-dependent of infection when re-infected with a heterologous viral serotype.Development of specific dengue fever prevention has been underway since 1944 (since the discovery of viral agents of this disease) but the first and so far only licensed in 2015 tetravalent vaccine-Dengvaxia developed by the French pharmaceutical company Sanofi Pasteur has been effective in varying degrees of protection against infection with each of the viral serotypes and in addition dangerous for previously seronegative people. Research aimed at obtaining a safe and effective vaccine is continuing. Neutralizing monoclonal antibodies are a necessary tool for studying the antigenic structure of viral immunogens as base of prevention preparates against dengue fever.
COVİD-19 PANDEMİSİNDE BİR ÜNİVERSİTE HASTANESİ CERRAHİ ONKOLOJİ KLİNİĞİNDE KANSER CERRAHİSİ DENEYİMİ
Authors: ZİHNİ İsmail , TERCAN Mustafa , BODUR Muhammed Selim , ERAKIN Mümtaz , KARACA İsa , ÇELİK Girayhan , SÖZEN İsa , SABUNCUOGLU Mehmet , ÇETİN Recep 
Published: March 2022

Amaç
Çin Halk Cumhuriyeti’nde ortaya çıkan ve küresel olarak
salgına dönüşen Koronavirüs Hastalığı (Covid-19)
bütün evrende olduğu gibi ülkemizde de kanser cerrahisini
etkiledi. Salgının etkilediği birçok ülkede elektif
ameliyatlar ertelendi. Çalışmamızda pandemide
Süleyman Demirel Üniversitesi Tıp Fakültesi Cerrahi
Onkoloji Kliniği’nde yaptığımız malignite operasyonlarının
sonuçlarını ortaya koymayı amaçladık.
Gereç ve Yöntem
SDÜ Tıp Fakültesi Cerrahi Onkoloji Polikliniği’ ne başvuran
ve ameliyat edilmesi gerektiğine karar verilen
hastalar çalışmaya dahil edildi. Hepsine preoperatif
hazırlık sırasında Covid - 19 testi (PCR) uygulandı.
Takiplerde Covid - 19' un genel bulguları, yara durumları
ve cerrahi bulgular incelendi. Ameliyat öncesi tüm
hastalar cerrahi maske kullandılar. Doktorlar ve diğer
sağlık personelleri vizitleri esnasında ve muayeneleri
esnasında cerrahi maske taktılar ve tek kullanımlık lateks
eldivenler kullandılar.
Bulgular
SDÜ Tıp Fakültesi Cerrahi Onkoloji Kliniği’ nde 10
Mart 2020 ve 31 Haziran 2021 tarihleri arasında 138
malignite tanısı konulan hasta ameliyat edildi. Ameliyat
öncesi hastaların hiçbirinde Covid - 19 semptomları
(ateş, öksürük veya yorgunluk) yoktu. 2 hastada
(mide ve meme kanseri) Covid – 19 (PCR) testi pozitif
geldi. Pozitif gelen hastalar izole edilerek operasyonu
ertelendi. Postoperatif 15 günlük dönemde hiçbir hastada
Covid - 19 semptomu görülmedi. Tüm hastalar
komplikasyonsuz bir şekilde taburcu edildiler.
Sonuç
Covid - 19 Pandemisi süresince kanser hastalarının
cerrahi endikasyon dahilinde doğru yönetilmesi hem
acil durumlara bağlı ölümlerin önüne geçilmesi, hem
de doğru tedavi uygulanması açısından önemlidir.
Cerrahi ekip ve hastalar için gerekli önlemlerin alınması
şartıyla, kanser hastalarının pandemi döneminde
güvenli şekilde ameliyat edilebileceği gösterilmiştir.
Application of chondroprotective agents to inhibit osteodestructive processes in the subchondral bone in patients with osteoarthritis
Authors: Gromova О. А. , Lila А. М. , Torshin I. Yu. , Reier I. А. 
Published: March 2022

Background. Osteoarthritis (OA) is associated with an activation of local inflammation and involves subchondral tissue of the joint.Objective: to conduct a systemic analysis of the publications on the association between OA and metabolic disorders in bones.Material and methods. The authors analyzed 3,926 publications on the studies of OA and metabolic disorders in bones tissue by the method of a topologic theory of recognition selected by the request “osteoarthritis AND (bone resorption OR osteopenia OR osteoporosis)” in the database of biomedical publications PubMed/MEDLINE. The control sampling included 4,000 articles randomly selected out of 97,331 found by the request “osteoarthritis NOT bone NOT resorption NOT osteopenia NOT osteoporosis” (i.e. publications on OA that do not cover issues of bone metabolism).Results. The associations between cartilaginous pathology and bone tissue destruction are mediated by anti-inflammatory cytokines, osteoblast and osteoclast balance impairments, steroid hormone imbalance, and carbohydrate metabolism. Bone metabolism disorders are associated with an intensification of OA-associated pain syndrome. Chondroprotective agents (chondroitin sulfate (CS), glucosamine sulfate (GS), and undenaturated collagen) block the activity of anti-inflammatory cytokines (NF-κB and toll-receptors), stimulate the activity of osteoblasts (bone tissue synthesizing cells), and decrease the excessive activity of osteoclasts (cells that degrade bone tissue).Conclusion. Pharmaceutically standardized forms of CS and GS can be used for the normalization of bone metabolism along with safe osteoptotective means (vitamin D, calcium, etc.) in patients with OA.
Impact of ASCI Sponsored Skill Development Trainings on Dairy Farming Practices: An Empirical Analysis
Authors: Thakur Devesh , Sharma Manoj , Dinesh Krishanender 
Published: March 2022

Background: The present study assessed the impact of Agricultural Skill Council of India (ASCI) funded dairy training programme conducted at CSKHPKV Palampur, Himachal Pradesh. These skill development training programs of 200 contact hours trained 40 participants in two trainings conducted in 2018 and 2019. Impact of these trainings was understood by studying changes in adoption, herd size, milk production and capital investments made before and after the trainings. Methods: A semi-structured interview schedule was designed for the collection of data before the start of training programme to assess socio-economic profile, herd size, milk production and adoption of various dairy farming practices. Post training data in March 2021 was collected to study the impact of trainings. The adoption index was calculated by procedure laid out by Mande and Thombre (2009) and Godara et al. (2018). Result: Significant differences in adoption of various practices before and after training were observed with few notable practices such as silage making, castration of male calves, screening of animals for sub clinical mastitis, cattle insurance and biogas production which scored lower adoption even post training. Lack of proper financial support from the banks, poor milk marketing and other socio-psychological factors prevented farmers from reaping full benefits post training.
Factors Affecting Primiparous Women’s Breastfeeding Self-Efficacy Levels
Authors: Erkal Aksoy Yasemin , Bay Habibe , Dereli Yilmaz Sema 
Published: March 2022

IntroductionThe aim of this study is to reveal the factors affecting primiparous pregnant women’s breastfeeding self-efficacy levels. This is a descriptive correlational study.MethodThe sample included 512 primiparous pregnant women. A personal information form, the Prenatal Breastfeeding Self-Efficacy Scale (PBSES), the Multidimensional Scale of Perceived Social Support (MSPSS) and the Pregnancy-Related Anxiety Questionnaire–Revised (PRAQ-R2) were used for data collection.ResultsThe pregnant women’s mean total PBSES scores were found to differ significantly based on their descriptive and obstetric characteristics. There was a positive correlation between their mean PBSES scores and their MSPSS total and subscale mean scores. Additionally, there was a negative correlation between the participants’ mean total PBSES scores and their mean total PRAQ-R2 and “concern about own appearance” subscale scores. Place of residence for the longest time, pregnancy risk group, folic acid use before pregnancy, perceived family support, perceived support from friends and concern about own appearance were significant factors in explaining the variance in the pregnant women’s PBSES total scores.DiscussionBoth descriptive and obstetric characteristics of the primiparous pregnant women affected their breastfeeding self-efficacy levels. Social support was also determined to affect the participants’ breastfeeding self-efficacy levels positively, and whereas anxiety affected these levels negatively.
Breastfeeding During Travel: Barriers and Informational Support for Mothers Traveling With or Without Infants
Authors: Hirani Shela Akbar Ali 
Published: March 2022

IntroductionAlthough breastfeeding during air travel is recommended, mothers often face various challenges when doing so.MethodsA review of evidence-based and grey literature was undertaken to examine key considerations surrounding breastfeeding during air travel, barriers encountered by breastfeeding mothers while traveling, and need-based informational support for breastfeeding mothers traveling with or without their infants.ResultsRegardless of whether breastfeeding mothers are traveling with or without their children, they require adequate information on airport screening processes, ways to maintain breastfeeding practices during travel, safe storage of expressed breastmilk, airport lactation amenities, the cultural context and breastfeeding laws of the country of travel, and infection protection measures, to assure safety and reduce health risks.ConclusionThe role of informational and social support is essential for promoting, protecting, and supporting the breastfeeding practices of mothers during air travel.
AGRICULTURA FAMILIAR EM TEMPOS DE PANDEMIA DO COVID-19
Authors: Pacheco Porto Carmem Rejane , Lagassi Tiago Ribeiro 
Published: March 2022

A COVID-19 é uma doença causada por um vírus da família dos coronavírus, mais precisamente pelo vírus SARS-CoV-2, afetou e vem afetando o modo de vida de todas as pessoas no mundo inteiro, caracterizando-se como uma pandemia ao qual é altamente contagiosa. Este trabalho busca fazer um apanhado sobre os problemas gerados pela COVID-19, visando compreender os impactos sobre a agricultura familiar no Brasil. A metodologia adotada foi a realização de uma pesquisa básica de caráter exploratória. Como procedimento foi empregada a pesquisa bibliográfica e se configurou com a finalidade qualitativa. Os locais de pesquisa incluíram sites, periódicos, revistas, livros e diversos tipos de artigos disponíveis para acesso online. Cada região brasileira foi impactada de forma diferente, umas mais devido ao território ser pouco valorizado politicamente e outras menos por já terem um histórico maior de desenvolvimento político e econômico. Portanto, se faz necessária pesquisas mais aprofundadas e locais, levando em consideração a situação do município em questão e as políticas adotadas pelos governos estaduais e municipais.
Digestibility of Swine Liver and Swine Meat Protein Hydrolysates by Nile Tilapia
Authors: Cardoso Matheus dos Santos , Nettson Luciana Valéria , de Freitas Jaqueline Marcela Azambuja , Lewandowski Vanessa , Signor Altevir , Boscolo Wilson Rogério , Bittencourt Fábio 
Published: March 2022

Abstract
The aim of this study was to evaluate the digestibility of protein, amino acids and energy of hydrolysates made of swine liver and swine meat by the Nile tilapia. The fish were distributed in 12 tanks with conical bottoms, in a completely randomized design with three treatments and four replicates, characterized by a control treatment and two diets containing the test ingredients: swine liver hydrolysate and swine meat hydrolysate. The coefficient of apparent digestibility was higher for both hydrolysates in comparison to the control, with percentages above 83% for dry matter 95% for crude protein and 92% for energy. Regarding amino acids, the coefficients remained at 98-100% for both hydrolysates. The digestibility percentages of both hydrolysates were higher than commonly used ingredients in the formulation of diets for Nile tilapia, of both plant and animal-origin. The hydrolysates tested in this study presented an excellent use in relation of essential amino acids by the Nile tilapia. Based on the results of digestibility, digestible energy and protein in this study, swine liver and meat hydrolysates have the potential to be used in the formulation of diets for this commercially important fish species.
Different Surgical Options for the Management of Intracranial Arachnoid Cysts
Authors: Kayhan Sait , Doğan Adem 
Published: March 2022

Abstract
Background: The aims of this study are to present our results and determine the most effective method on the surgical treatment of intracranial arachnoid cysts.Methods: The data of 44 patients who underwent surgical treatment for intracranial arachnoid cyst between 2011 and 2019 were retrospectively reviewed. Age, gender, location of the cyst, clinical presentation, surgical technique and outcomes of patients were recorded and analyzed. The results were compared statistically. Results: Among the 44 patients, 36 were male and 8 were female with a mean age of 19.77 years. Twelve patients were children and 32 were adults. Signs of increased intracranial pressure were observed in 35 patients and epilepsy in 9 patients. The most frequent locations were temporal, frontotemporal and frontoparietal regions. Cyst fenestration was used in 34 patients while, cystoperitoneal shunt+fenestration in 8 and only shunt in 2 patients. Subdural effusion was seen in 5 patients and wound dehiscence in 6 patients after surgery. Forty patients were improved after surgery while 4 patients remained symptomatic during the follow-up period.Conclusions: Cyst fenestration is the most effective treatment method for intracranial arachnoid cysts. It may be performed using either microscopic or endoscopic technique. Re-closure of the fenestration is the main problem especially when performed in young children.
Unilateral Diaphragm Paralysis Following COVID-19 Infection
Authors: Lowenkamp Mikayla N. , Vercauteren Matthew , Crist Lawrence , Dhupar Rajeev 
Published: March 2022

Abstract
Background:New neurologic manifestations of the SARs-CoV-2 virus are emerging. We report a rare case of unilateral diaphragm paralysis following COVID-19 infection. Case Presentation:A 55 year-old previously healthy person was infected with SARs-CoV-2 prior to the availability of a vaccine. This patient was intubated and pronated for respiratory failure. For 6-months after recovery he experienced new debilitating dyspnea and orthopnea. Dynamic chest radiography demonstrated severely impaired motion of the right hemidiaphragm, representing a new hemi-diaphragm paralysis. After surgical plication the symptoms resolved. Conclusions:This case demonstrates the importance of thorough evaluation for diaphragm paralysis in patients who have suffered COVID-19 infection when there is persistent dyspnea or orthopnea, as well as the neuroinvasive potential of the virus that has yet to be fully explained.
An externally validated normogram for predicting short-term pregnancy outcome of singleton pregnancies with fetal growth restriction (FGR)
Authors: Yin Fufen , Jin Mingrui , Li Yujing , Li Yang , Yin Xiuju , Xie Junshu , Zhang Xiaohong 
Published: March 2022

Abstract
Background: The object of this study was to develope an available predictive model of singleton pregnancies with fetal growth restriction (FGR) for accurate and individualized prognosis assessment. Methods: The prediction nomogram was developed by multivariable Cox regression with data for 301 singleton FGR pregnancies at Peking University People’s Hospital. External validation was performed in 321 eligible singleton FGR pregnancies at the Affiliated Hospital of Qingdao University. Results: Absent umbilical arterial flow, fetal anomaly, history of adverse pregnancy, non-head fetal position and history of caesarean section were independent prognostic factors for adverse perinatal outcomes (APOs) in singleton FGR pregnancies in the training set. The nomogram estimated pregnancy prognosis of FGR singleton pregnancies based on these five variables, with a C-index of 0.859 in the training cohort. In the external validation set, consistent results were observed with a C-index of 0.776 for the nomogram. Moreover, the calibrations of the nomograms predicting 28th and 34th TOP-free gestation week (GW) strongly corresponded to the actual survival outcome. Conclusion: The prediction model in this study may help clinicians in decision-making for singleton pregnancies with FGR, especially for the patient with single abnormal umbilical arterial flow or fetal anomaly, without induced labor indications for these abnormalities.
Environmental impact of mining and beneficiation of copper sulphate mine based on life cycle assessment
Authors: Tao Ming , Nie Kemi , Zhao Rui , Shi Ying , Cao Wenzhuo 
Published: March 2022

Abstract
China is a major producer of copper concentrate as its smelting capacity continues to expand dramatically. The present study analyzes the life cycle environmental impact of copper concentrate production, along with selection of a typical copper sulphate mine in China. Life cycle assessment (LCA) was conducted using SimaPro with ReCiPe 2016 method. The midpoint and endpoint results were performed with uncertainty information based on Monte Carlo calculation. Normalization of midpoint results revealed that impact from the marine ecotoxicity category was the largest contributor to the total environmental impact, followed by freshwater ecotoxicity, human carcinogenic toxicity, human non-carcinogenic and terrestrial ecotoxicity. The mining activity, backfilling activity and electricity generation were proved to be the dominant factors. In addition, main processes and substances to the identified key categories were also classified. Specifically, the cement production in the backfilling process, blasting activity, on-site emission and electricity generation were regarded as the critical processes. Copper to air and zinc emission to water were considered as the critical substances. The sensitivity analysis indicated that controlling on-site emissions and reducing pollution from cement production were the most effective measure to solve the environmental problems caused by the concentrate production process. Finally, the corresponding technical and management measures were proposed to facilitate the development of cleaner metal industry.
Evaluation of HyperArcTM using film and portal dosimetry quality assurance
Authors: Kamst Onno , Desai Pushkar 
Published: March 2022

Abstract
HyperArc™ is a stereotactic radiotherapy modality designed for targeting multiple brain metastases using a single isocenter with multiple non-coplanar arcs. The purpose of this study was to assess the efficacy of two patient specific quality assurance methods, film and the Varian Portal Dosimetry System with Varian’s HyperArc™ technique and raise important considerations in the customisation of patient specific quality assurance to accommodate HyperArc™ delivery. Assessment criteria included gamma analysis and mean dose at full width half maximum. The minimum met size, maximum off-axis distance and suitable energy were identified and validated. Patient specific quality assurance procedures were applied to a range of clinically relevant brain met plans. Initial investigation into energy selection showed no significant differences in gamma pass rates using 6MV, 6MV FFF or 10MV FFF for met sizes greater than 15 mm diameter at the isocenter. Gamma pass rates (2%/2mm) for 15 mm mets at the isocenter for all energies were greater than 96.0% for portal dosimetry and greater than 98.7% for film. Fields of size 15 mm placed at various distances (10–70 mm) from the isocenter resulted in a maximum mean dose difference of 1.5% between film and planned. Clinically relevant plans resulted in maximum mean dose difference for selected mets of 1.0% between film and plan and maximum point dose difference of 2.9% between portal dose and plan. Portal dose image prediction was found to be a quick and convenient quality assurance tool for mets larger than 15 mm near the isocenter but provided diminished geometrical relevance for off-axis mets. Film QA required exacting procedures but offered the ability to assess the accuracy of geometrical targeting for off-axis mets and provided dosimetric accuracy for mets to well below 15 mm diameter.
Influence of Microsurgical Decompression on Segmental Stability of the Lumbar Spine – One-Year Results in a Prospective, Consecutive Case Series Using Upright, Kinetic-Positional MRI
Authors: Daentzer Dorothea , Venjakob Elina , Schulz Jessica , Schulze Thorsten , Schwarze Michael 
Published: March 2022

Abstract
BackgroundStandard procedure in patients with lumbar spinal canal stenosis is decompressionto relieve the neural structures. Clinical results generally show superiority compared to nonoperative therapy after an observation period of several years. However, there is still a question of postsurgical segmental stability and correlation to clinical findings. Therefore, the aim of this prospective study was to evaluate the clinical outcome in patients who underwent microsurgical decompressionin lumbar spine and particularly to analyze intervertebral movement by use of upright, kinetic-positional magnetic resonance imaging (MRI) over a period of 12 months and then to correlate the clinical and imaging data with each other.MethodsComplete clinical data of 24 consecutive participants with microsurgical decompression of the lumbar spine were obtained by questionnaires including visual analogue scale (VAS) for back and leg, Oswestry Disability Index (ODI), Roland-Morris Disability Questionnaire (RMDQ), Short-Form-36 (SF-36), walking distance and use of analgesics with assessment preoperatively and after 6 weeks and 12 months.At the same points of time all patientsunderwent upright, kinetic-positional MRIto measure intersegmental motion of the operated levels with determination of intervertebral angles and translation and to correlate the clinical and imaging data with each other. Results VAS for leg, ODI, RMDQ and physical component scale of SF-36 improved statistically significantlywithout statistically significant differences regarding intersegmental motion and horizontal displacement 6 weeks and 12 months after operation. Regression analysis did not find any linear dependencies between the clinical scores and imaging parameters.ConclusionsOurresults demonstrate no increase of intersegmental movement or even instability after microsurgical decompression of the lumbar spine over a follow-up period of 12 months, which is equivalent to preservation of intervertebral stability. Furthermore, the magnitude of intervertebral range of motion showed no correlation to the clinical score parameters at all three examination points of time.