bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD25: A potential tumor therapeutic target
Authors: Peng Yujia , Tao Yiran , Zhang Ya , Wang Jiaxing , Yang Jinliang , Wang Yuxi 
Published: September 2022

AbstractCD25 is the alpha‐chain of the heterotrimer IL‐2 receptor. CD25 is expressed on the surface of both immune and non‐immune cells with different frequencies. For cancers, CD25 is expressed at high levels in many types of hematological malignancies, but at low levels in most solid tumors. CD25 is also highly expressed in activated circulating immune cells and regulatory T cells (Tregs). Infiltration of Tregs in the tumor microenvironment can lead to an imbalanced ratio of effector T cells (Teffs) and Tregs, which is associated with the progression of cancers. A rescued Teff/Treg cell ratio indicates an efficient anti‐tumor response to immunotherapy. CD25 as a potential target for the depletion of Tregs is critical in developing new immunotherapeutic strategies. Few articles have summarized the relationships between CD25 and tumors, or the recent progress of drugs targeting CD25. In this paper, we will discuss the structures of IL‐2 and IL‐2R, the biological function of CD25 and its important role in tumor therapy. In addition, the latest research on drugs targeting CD25 has been summarized, providing guidance for future drug development.
Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents
Authors: Marshall Gregory P. , Cserny Judit , Wang Chun‐Wei , Looney Benjamin , Posgai Amanda L. , Bacher Rhonda , Keselowsky Benjamin , Brusko Todd M. 
Published: September 2022

AbstractType 1 diabetes (T1D) presents with two therapeutic challenges: the need to correct underlying autoimmunity and restore β‐cell mass. We harnessed the unique capacity of regulatory T cells (Tregs) and the T cell receptor (TCR) to direct tolerance induction along with tissue‐localized delivery of therapeutic agents to restore endogenous β‐cell function. Specifically, we designed a combinatorial therapy involving biomaterials‐based poly(lactic‐co‐glycolic acid) nanoparticles co‐loaded with the Treg growth factor, IL‐2, and the β‐cell regenerative agent, harmine (a tyrosine‐regulated kinase 1A [DYRK1A] inhibitor), conjugated to the surface of Tregs. We observed continuous elution of IL‐2 and harmine from nanoparticles for at least 7 days in vitro. When conjugated to primary human Tregs, IL‐2 nanoparticles provided sufficient IL‐2 receptor signaling to support STAT5 phosphorylation for sustained phenotypic stability and viability in culture. Inclusion of poly‐L‐lysine (PLL) during nanoparticle‐cell coupling dramatically increased conjugation efficiency, providing sufficient IL‐2 to support in vitro proliferation of IL‐2‐dependent CTLL‐2 cells and primary murine Tregs. In 12‐week‐old female non‐obese diabetic mice, adoptive transfer of IL‐2/harmine nanoparticle‐conjugated NOD.BDC2.5 Tregs, which express an islet antigen‐specific TCR, significantly prevented diabetes demonstrating preserved in vivo viability. These data provide the preclinical basis to develop a biomaterials‐optimized cellular therapy to restore immune tolerance and promote β‐cell proliferation in T1D through receptor‐targeted drug delivery within pancreatic islets.
Engagement in Primary Prevention Program among Rural Veterans With Osteoporosis Risk
Authors: Miller Karla L. , Mccoy Kimberly , Richards Chris , Seaman Aaron , Solimeo Samantha L. 
Published: September 2022

ABSTRACTA primary osteoporosis prevention program using a virtual bone health team (BHT) was implemented to comanage the care of rural veterans in the Mountain West region of the United States. The BHT identified, screened, and treated rural veterans at risk for osteoporosis using telephone and United States Postal Service communications. Eligibility was determined by regular use of Veterans Health Administration primary care, age 50 or older, and evidence of fracture risk. This study was conducted to identify demographic and clinical factors associated with the acceptance of osteoporosis screening and the initiation of medication where indicated. A cross‐sectional cohort design (N = 6985) was utilized with a generalized estimating equation and logit link function to account for facility‐level clustering. Fully saturated and reduced models were fitted using backward selection. Less than a quarter of eligible veterans enrolled in BHT's program and completed screening. Factors associated with a lower likelihood of clinic enrollment included being of older age, unmarried, greater distance from VHA services, having a copayment, prior fracture, or history of rheumatoid arthritis. A majority of veterans with treatment indication started medication therapy (N = 453). In this subpopulation, Fisher's exact test showed a significant association between osteoporosis treatment uptake and a history of two or more falls in the prior year, self‐reported parental history of fracture, current smoking, and weight‐bearing exercise. The BHT was designed to reduce barriers to screening; however, for this population cost and travel continue to limit engagement. The remarkable rate of medication initiation notwithstanding, low enrollment reduces the impact of this primary prevention program, and findings pertaining to fracture, smoking, and exercise imply that health beliefs are an important contributing factor. Efforts to identify and address barriers to osteoporosis screening and treatment, such as clinical factors, social determinants of health, and health beliefs, may pave the way for effective implementation of population bone health care delivery systems. Published 2022. This article is a U.S. Government work and is in the public domain in the USA. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Responding to everyday problems and crises: Measuring community resilience
Authors: Tavares Lara Patrício , Luís Sílvia , Henriques Joana , Marujo Helena Águeda , Gonçalves Sónia P. , Rivero Catarina 
Published: September 2022

AbstractResilience is of the upmost importance to deal with everyday problems faced by communities. The concept of community resilience is gaining prominence in disaster management policy and practice, and it has been shown to be an important factor during pandemic recovery such as during the SARS‐CoV‐2 outbreak. We present an instrument for community resilience assessment adapted for disasters like the pandemics. The instrument was based on the theory‐based and evidence‐informed Communities Advancing Resilience Toolkit (CART) Assessment Survey, adapted for the first time to Portuguese. Another strong feature of this study relates to the targeted participants, namely human service workers (598). They are key informants for their close involvement with communities. This version of the CART was reliable. A confirmatory factor analysis indicated a good relationship between the observed variables and their underlying latent constructs. Moreover, tests for measurement invariance across participants showed that differences in factor variances and covariances were not attributable to age‐based differences in the properties of the scales themselves. Our findings support the fundamental idea that it is worthwhile to have an instrument to measure community resilience. Thus, our study adds to the evaluation of the CART, supporting its value as a robust instrument to measure resilience at the community level in different countries.
Animal model testing for efficacy and adverse effects of bacteriophages against Acinetobacter baumannii
Authors: Hussain Aamir , Ullah Ihsan , Saeed Muhammad Q. 
Published: September 2022

AbstractThis study aimed to conduct a detailed study on murine model testing of bacteriophage against Acinetobacter baumannii. These bacteriophages were tested not only for their efficacy in healing wound of murine models infected with multidrug resistant A. baumannii but were also studied for any derangement in hematological parameters as well as liver and kidney function. The study also included any histological changes observed in hepatic and renal tissues of the bacteriophage treated murine animals. This experimental study was conducted at Institute of Basic Medical Sciences, Khyber Medical University, Peshawar and Institute of Pure and Applied Biology, Department of Microbiology and Molecular Genetics, Bahauddin Zakariya University, Multan. A. baumannii isolates were obtained from the Microbiology Department, Armed Forces Institute of Pathology, Rawalpindi. Antimicrobial susceptibility was done by using standard procedures and as per Clinical Laboratory Standards Institute guidelines. Bacteriophages were isolated from sewage water samples collected from different hospitals in Multan. These bacteriophages were characterized and finally used for treating the murine model and efficacy of phage as a therapeutic option was determined by using superficial rat wound model. In this study, the isolated lytic bacteriophage was effective in relatively faster wound healing of the infected animals. Moreover, there were no significant hematological or renal and hepatic profile changes in treated animals. Histology of renal and hepatic tissues was also normal as compared to control animals. Our study concluded that the isolated phage could serve as an attractive therapeutic candidate to combat the deadly multidrug resistant A. baumannii.
Feasibility of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced peritoneal surface tumors during the COVID‐19 pandemic: A single‐institution experience
Authors: Radomski Shannon N. , Florissi Isabella , Khan Hamza , Siddiqi Amn , Paneitz Dane C. , Johnston Fabian M. , Greer Jonathan B. 
Published: September 2022

AbstractBackground and objectivesCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex treatment used in selected patients with peritoneal surface malignancies. HIPEC procedures are time and resource intensive. The primary aim of this analysis was to compare the experience of treating advanced abdominal tumors with CRS‐HIPEC before and during the coronavirus disease 2019 (COVID‐19) pandemic.MethodsPatients included in this analysis received CRS‐HIPEC at a single center during either a prepandemic (March 18, 2019–March 17, 2020) or pandemic (March 18, 2020–February 5, 2021) interval. A retrospective chart review was performed.ResultsOur analysis included 67 patients: 30 (45%) treated prepandemic and 37 (55%) treated during the pandemic. Median age at the time of operation was 58 years (interquartile range: [49–65]); 53% of patients were women. Patients treated during the pandemic presented with higher peritoneal cancer index (PCI) scores with 32% (n = 12) having a PCI > 20 at the time of surgery (p = 0.01). Five patients had delays in surgery due to the pandemic. Rates of overall postoperative morbidity, reoperation, and readmission were not different between the cohorts.ConclusionsDespite presenting with more extensive disease, patients treated with CRS‐HIPEC during the height of the COVID‐19 pandemic had comparable perioperative outcomes to patients treated prepandemic.
Advances in Energy‐Level Systems of Organic Lasers
Authors: Wu Jun‐Jie , Wang Xue‐Dong , Liao Liang‐Sheng 
Published: September 2022

AbstractOrganic gain materials, with the merit of abundant excited‐state processes with large stimulated emission cross‐section, show considerable potential in lasers. The abundant excited‐state processes provide excellent platform for the construction of various forms of energy‐level systems, based on which the efficient population inversion and the tailorable gain region are supported. Herein, the development of organic lasers with distinctive energy‐level systems is summarized according to the classification of excited‐state gain processes including singlet quasi‐four‐level transition, energy transfer, excimer, charge transfer (CT), excited‐state intramolecular proton transfer (ESIPT), and some other novel photophysical processes, giving deep insight into the inherent relationship between energy‐level systems and laser action. Finally, the challenges and perspectives for the future development are presented, hopefully to offer valuable enlightenment for the further optimization of energy‐level systems toward high‐gain organic lasers including electrically pumped organic lasers.
Self‐Aligned Polymer Film Patterning on Microstructured Silicon Surfaces
Authors: Schutzeichel Christopher , Kiriy Nataliya , Kiriy Anton , Voit Brigitte 
Published: September 2022

AbstractBased on a recently developed selective etching process for silicon samples with buried implants, this work presents a method for utilizing the generated material contrast between silicon and silicon oxide to selectively deposit polymers on the patterned surface. Besides depositing polystyrene selectively on the etched parts via drop‐casting and dewetting, polymer chains are selectively grafted to the oxidic surface parts. To this end, the oxide surfaces are selectively modified via functional alkoxysilanes, whereas etched silicon surfaces are unreactive. Using either a two‐step or a straight‐forward one‐step process employing commercially available chemicals, atom transfer radical polymerization (ATRP) initiator functions are attached selectively to the non‐etched surface areas, and subsequently used to polymerize either methyl methacrylate (MMA) or N‐isopropyl acrylamide (NIPAM) in a controlled surface‐initiated activator regenerated by electron transfer (ARGET)‐ATRP process. This procedure allows for the further self‐aligned functionalization of the micropatterned samples, enabling the production of highly functional, patterned surfaces, potentially suitable for applications in areas such as cell adsorption, microfluidics, or functional microsystems, e.g., MEMS.
The assignment of 11B and 1H resonances in the post‐reaction mixture from the dry synthesis of Li(BH3NH2BH2NH2BH3)
Authors: Nawrocka Ewa K. , Prus Agnieszka , Owarzany Rafał , Koźmiński Wiktor , Kazimierczuk Krzysztof , Fijalkowski Karol J. 
Published: September 2022

AbstractWe report a detailed
NMR and
NMR study of as synthesised
obtained in a novel dry‐synthesis method. A combination of 1D and 2D single‐ and triple‐quantum techniques was used for the assignment of all observed signals. Minor side‐products and reactants were detected in the product:
,
,
, and two yet unknown salts containing 7‐membered chain anions:
and
. We believe the assignment provided within this study might be helpful when analysing the mixtures containing numerous ammonia borane derivatives, which often give overlapping signals that are hard to distinguish.
Pass the torch: Leadership development and succession planning in nonprofit organizations
Authors: Johnson Brian Lee 
Published: September 2022

AbstractSuccession planning is similar to the process of purchasing life insurance. Few people enjoy doing so, and even fewer take pleasure in discussing the reasons why it is needed. However, for long‐term stability purposes, both are necessary to prepare for the future. Life insurance is purchased with the mindset of protecting loved ones. Can this same mindset carry over to succession planning for nonprofit organizations (NPOs), which many stakeholders deeply care for as well? Research points to the coming mass departure of NPO executives. Consequently, NPOs must know how to prepare for this exodus. In this paper, information is presented from relevant literature regarding succession planning within NPOs, including who is currently in the executive positions, why this change is happening, what problems can occur during the transition process, and which methods can be used to solve them. Furthermore, guidance is provided on who should be directly involved in the succession process and how these individuals can develop future leaders from within the NPO. Everything is examined through the lens of two leadership theories: transformational leadership and shared leadership. Hopefully, this paper inspires NPOs to start a conversation on leadership development and succession planning within their organizations.
Potential of polyhydroxyalkanoate and nanocellulose from oil palm trunk as raw materials for additive manufacturing: A review
Authors: Jeffri Noorfarisya Izma , M. R. Nurul Fazita , Leh Cheu Peng , Hashim Rokiah , M.K Mohamad Haafiz , Ibrahim Mazlan , Tay Guan Seng , Arai Takamitsu , Sudesh Kumar , Kosugi Akihiko 
Published: September 2022

AbstractAdditive manufacturing (AM) is beneficial due to its fast prototyping, non‐complexity process, flexibility, which allows for a wide range of innovations. The AM presented in this review concentrated solely on the fused deposition modeling method. The application of polyhydroxyalkanoate (PHA) biopolymer in conjunction with AM technology in accordance with the interest of researchers in practicing sustainable development. Most studies discovered that the features of PHA, such as its brittleness, slow crystallization, and small processing window, may be overcome by blending it with other polymers. In particular, the physical and chemical properties of PHA have a strong influence on its printability in three‐dimensional printing. Furthermore, this article discussed the use of nanocellulose as a reinforcing material in PHA blends due to its high‐surface area, lightweight, and excellent biocompatibility. The limitations in creating and applying PHA were also highlighted, as it was expensive and difficult to process at high temperatures. Overall, this article provided an overview of AM, including the potential of oil palm trunk as a source of PHA and nanocellulose for bio‐composite products.
Integrated changes in thermal stability and proteome abundance during altered nutrient states in Escherichia coli and human cells
Authors: Sultonova Mukhayyo , Blackmore Beau , Du Ronnie , Philips Olivier , Paulo Joao A. , Murphy John Patrick 
Published: September 2022

AbstractAltered thermal solubility measurement techniques are emerging as powerful tools to assess ligand binding, post‐translational modification, protein–protein interactions, and many other cellular processes that affect protein state under various cellular conditions. Thermal solubility or stability profiling techniques are enabled on a global proteomic scale by employing isobaric tagging reagents that facilitate multiplexing capacity required to measure changes in the proteome across thermal gradients. Key among these is thermal proteomic profiling (TPP), which requires 8–10 isobaric tags per gradient and generation of multiple proteomic datasets to measure different replicates and conditions. Furthermore, using TPP to measure protein thermal stability state across different conditions may also require measurements of differential protein abundance. Here, we use the proteome integral stability alteration (PISA) assay, a higher throughput version of TPP, to measure global changes in protein thermal stability normalized to their protein abundance. We explore the use of this approach to determine changes in protein state between logarithmic and stationary phase Escherichia coli as well as glucose‐starved human Hek293T cells. We observed protein intensity‐corrected PISA changes in 290 and 350 proteins due to stationary phase transition in E. coli and glucose starvation, respectively. These data reveal several examples of proteins that were not previously associated with nutrient states by abundance alone. These include E. coli proteins such as putative acyl‐CoA dehydrogenase (aidB) and chaperedoxin (cnoX) as well as human RAB vesicle trafficking proteins and many others which may indicate their involvement in metabolic diseases such as cancer.
Pharmacological hypothesis: A recombinant probiotic for taming bacterial β‐glucuronidase in drug‐induced enteropathy
Authors: Jardou Manon , Brossier Clarisse , Guiyedi Kenza , Faucher Quentin , Lawson Roland 
Published: September 2022

AbstractAdvances in pharmacomicrobiomics have shed light on the pathophysiology of drug‐induced enteropathy associated with the therapeutic use of certain non‐steroidal anti‐inflammatory drugs, anticancer chemotherapies and immunosuppressants. The toxicity pathway results from the post‐glucuronidation release and digestive accumulation of an aglycone generated in the context of intestinal dysbiosis characterized by the expansion of β‐glucuronidase‐expressing bacteria. The active aglycone could trigger direct or indirect inflammatory signaling on the gut epithelium. Therefore, taming bacterial β‐glucuronidase (GUS) activity is a druggable target for preventing drug‐induced enteropathy. In face of the limitations of antibiotic strategies that can worsen intestinal dysbiosis and impair immune functions, we hereby propose the use of a recombinant probiotic capable of mimicking repressive conditions of GUS through an inducible plasmid vector.
In Vitro Antimicrobial Screening of Benzoylthioureas: Synthesis, Antibacterial Activity toward Streptococcus agalactiae and Molecular Docking Study
Authors: Biasi‐Garbin Renata P. , Fabris Marciéli , Morguette Ana Elisa B. , Andriani Gabriella M. , Cabral Weslei R. C. , Pereira Patrícia M. L. , Brito Tiago O. , Macedo Fernando , Da Silva Lima Camilo H. , Lancheros César A. C. , Nakamura Celso V. , Pinge‐Filho Phileno , Tavares Eliandro R. , Yamauchi Lucy M. , Bispo Marcelle L. F. , Yamada‐Ogatta Sueli F. 
Published: September 2022

AbstractHerein, twenty‐six benzoylthioureas were evaluated for their antimicrobial activity against different bacterial and fungal species. Two 4‐substituted benzoylthiourea, one benzoylurea and one benzoylguanidine derivatives were further synthesized to identify the most promising compound. Eight compounds were active against at least one microbial species tested. N‐(butylcarbamothioyl)‐benzamide (1 e) exhibited the best antimicrobial activity towards Streptococcus agalactiae (group B Streptococcus‐GBS), including clinical isolates susceptible or resistant to clindamycin and/or erythromycin and azithromycin. 1 e presented a bacteriostatic effect, causing morphological and ultrastructural alterations on planktonic cells, and decreased the metabolic activity of GBS biofilms. No hemolytic and cytotoxicity to mammalian cells were detected for 1 e, that also displayed drug‐likeness properties. Molecular docking was performed on Streptococcus pneumoniae enoyl‐ACP reductase obtained by homology modeling. 1 e showed relevant interactions with the GBS enoyl‐ACP reductase enzyme. N‐(butylcarbamothioyl)‐benzamide may be a good starting point for the development of new antimicrobials against GBS.
Use of Dialkyl Acetylenedicarboxylates in the Multicomponent Synthesis of Heterocyclic Structures
Authors: Rezvanian Atieh , Khodadadi Behnoosh , Tafreshi Sepideh 
Published: September 2022

AbstractDialkyl acetylenedicarboxylates (DAAD) are the class of acetylenic compounds that are broadly used in organic synthesis in a noticeable quantity. Their wide application has made them an important moiety in heterocyclic compounds and drug discovery programs. Dialkyl acetylenedicarboxylate is a di‐ester in which the ester groups are conjugated with a carbon‐carbon triple bond. As such, the molecule is very electrophilic, and is broadly used as a dienophile in various cycloaddition reactions, for example the Diels‐Alder reaction. In addition, it is a strong Michael acceptor. Due the importance of dialkyl acetylenedicarboxylate in organic synthesis, we are trying to show the applications of this compound in the synthesis of different heterocycles using multicomponent reactions. In this review, we show recent advances (2016–2022) for the synthesis of various heterocycles that have different ring sizes (five, six and seven membered, Spiro and fused heterocycles), using DAAD via multicomponent reactions.