bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abundance and Diversity of Coccinellid Predators in Rice Field Ecosystem in Payakumbuh District, Indonesia
Authors: Yudha Pajri Ananta , Dwipa Indra , Azwardi Dedi 
Published: June 2022

Aims: The study aimed to study the abundance and biodiversity of Coccinellid predators in rice field Ecosystem in Payakumbuh District, Lima Puluh Kota Regency, West Sumatera, Indonesia.
Study Design: Purposive random sampling.
Place and Duration of Study: The research was conducted in rice field of Payakumbuh District, Lima Puluh Kota Regency, West Sumatera and Laboratory of Pest, Faculty of Agriculture, Riau University, Pekanbaru, Indonesia from January to April 2022.
Methodology: Purposive random sampling was used in the research. Three rice fields in Payakumbuh District was chosen as sampling locations. Sweep net method was using to collect the coccinellid and the collected coccinellids were identified in Pest Laboratory, Faculty of Agriculture, Riau University, Pekanbaru, Indonesia. The data was analyzed by using Shannon-Winner diversity index to analyze biodiversity and evenness index.
Results: 30 individuals of three species of coccinelid predators were found in rice field ecosystem in Payakumbuh district. The species were Micraspis lineata (20 individuals), Menochilus sexmaculatus (9 individuals) and Coleophora bisselata (1 individual). The species diversity index (H’) and species evenness index (E) were 0.73 and 0.66 respectively.
Conclusion: The diversity of coccinellid predators in rice field in Payakumbuh district was quite stable and more stable.
Progranulin/Tumor Necrosis Factor-\(\alpha\) ratio in Psoriasis Vulgaris
Authors: Sheir Hoda S. , Badr Enayat A. , Hodeib Abeer A. , Zahra Mohammed K. 
Published: June 2022

Background and Aim: In psoriasis, the proteins Tumor Necrosis Factor (TNF) and interleukin-6 (IL-6) are overexpressed and play important roles in the disease's progression. For treating psoriasis, biological drugs that target TNF signaling are quite successful. Embryogenesis, tissue repair, cancer, neuronal survival, host defense, and inflammation are all dependent on progranulin (PGRN). By competing with TNF binding to TNFR1/2, PGRN inhibits TNF-mediated signaling pathways and has anti-inflammatory properties in inflammatory arthritis models. The current research seeks to study the relationship between serum PGRN / TNF - \(\alpha\)and psoriasis vulgaris activity.
Subjects & Methods: This study’s subjects were categorized into 2 groups: group 1 with 35 patients with psoriasis vulgaris, and group 2 of 30 healthy subjects with matched age and sex.
Results: We discovered a significant increase in PGRN and TNF-\(\alpha\)in cases versus control. And we have found a significant decrease in PGRN/TNF-\(\alpha\)ratio in cases versus control. We also detected significant differences between the Psoriasis Area Severity Index (PASI) degree and the levels of PGRN and TNF-\(\alpha\), as well as the PGRN/TNF-\(\alpha\)ratio. We discovered a negative significant correlation between PASI and PGRN/TNF-\(\alpha\)ratio.
Conclusion: Atsttrin exhibited potent anti-inflammatory properties due to its three modified granulin motifs and their associated linker regions. In the treatment of rheumatoid arthritis and contact dermatitis, PGRN and its derivative Atsttrin may be a potential therapeutic drug.
Pharmacist impact on medication reconciliation of behavioral health patients boarding in the emergency department
Authors: Accomando Mary , DeWitt Kyle , Porter Blake 
Published: June 2022

Abstract

Introduction
The high demand for psychiatric services has exceeded the capacity of available resources for behavioral health patients, forcing these patients to seek mental health care in the emergency department. Average lengths of stay for behavioral health boarders commonly extend over multiple days and prior-to-admission (PTA) medication administration may be delayed, which could lead to further deterioration and longer inpatient lengths of stay. Addition of a pharmacist-led medication reconciliation process and pharmacist integration into daily emergency department psychiatry rounds may decrease time to initiation of PTA medications and improve outcomes in this population.

Methods
This is a retrospective review of adult patients who required a psychiatric emergency evaluation in a large rural academic medical center emergency department. Objectives were to determine the number and type of medication discrepancies found with pharmacist intervention, and to compare time to initiation of PTA medications with a pharmacist versus a nonpharmacist completing medication reconciliation.

Results
A total of 139 patients were identified, 85 patients in August 2019 (no pharmacist [NP]) and 54 in October 2019 (pharmacist involvement [PI]). Among 484 medications reviewed in the PI group, 298 discrepancies were identified. The most common types of discrepancies were no longer taking (n = 99, 33%) and omission (n = 94, 32%). Time to administration of PTA medications was similar between NP and PI groups (median hours, interquartile range: NP: 10.8, 7.8-16.57; PI: 11.49, 6.16-16; P = .179).

Discussion
This study depicted one of the many values of pharmacists in the hospital setting, especially in the behavioral health patient population where continuation of accurate PTA medications may prevent further clinical deterioration.
Pharmacists in clozapine clinics improving physical health monitoring
Authors: Spann Greg , Austin Lewis , King Edward 
Published: June 2022

Abstract

Introduction
People living with schizophrenia have a higher rate of comorbid physical health diseases and compared with the general population die earlier due to these diseases. A pharmacist working in an outpatient mental health clinic setting could assist with the management of physical health disease for this population. The aim of this study was to investigate whether having a pharmacist in a community clozapine clinic would improve adherence to physical health monitoring and whether this would have a positive effect on these physical health outcomes.

Methods
This retrospective observational study compared patient data from 2 clozapine clinics; one where a pharmacist engaged in medication reviews and management of medication side effects, and another that did not have a pharmacist. The rates of physical health monitoring and the changes from baseline of physical health outcomes (weight, BMI, BP, HbA1c, and lipids) were compared after the first pharmacist intervention (medication review).

Results
The pharmacist clinic had statistically higher rates of metabolic and ECG monitoring (glucose 48% vs 11%, P &lt; .001; lipids 61% vs 7.1%, P &lt; .001; ECG 15% vs 0%, P = .001). Positive trends in weight were identified in the pharmacist-group, although this failed to reach statistical significance.

Discussion
This study shows that pharmacists providing regular medication reviews improves physical health monitoring for patients receiving clozapine.
Multimodalin vivostaging in amyotrophic lateral sclerosis using artificial intelligence
Authors: Behler Anna , Müller Hans‐Peter , Del Tredici Kelly , Braak Heiko , Ludolph Albert C. , Lulé Dorothée , Kassubek Jan 
Published: June 2022

AbstractBackgroundThe underlying neuropathological process of amyotrophic lateral sclerosis (ALS) can be classified in a four‐stage sequential pTDP‐43 cerebral propagation scheme. Using diffusion tensor imaging (DTI),in vivoimaging of these stages has already been shown to be feasible for the specific corticoefferent tract systems. Because both cognitive and oculomotor dysfunctions are associated with microstructural changes at the brain level in ALS, a cognitive and an oculomotor staging classification were developed, respectively. The association of these differentin vivostaging schemes has not been attempted to date.MethodsA total of 245 patients with ALS underwent DTI, video‐oculography, and cognitive testing using Edinburgh Cognitive and Behavioral ALS Screen (ECAS). A set of tract‐related diffusion metrics, cognitive, and oculomotor parameters was selected for further analysis. Hierarchical andk‐means clustering algorithms were used to obtain an optimal cluster solution.ResultsAccording to cluster analysis, differentiation of patients with ALS into four clusters resulted: Cluster A showed the highest fractional anisotropy (FA) values and thereby the best performances in executive oculomotor tasks and cognitive tests, whereas cluster D showed the lowest FA values, the lowest ECAS scores, and the worst executive oculomotor performance across all clusters. Clusters B and C showed intermediate results regarding parameter values.DiscussionIn a multimodal dataset of technical assessments of brain structure and function in ALS, an artificial intelligence‐based cluster analysis showed high congruence of DTI, executive oculomotor function, and neuropsychological performance for mappingin vivocorrelates of neuropathological spreading.
Observer‐based controller for nonaffine time‐delayed systems subject to input nonlinearities, state constraints, and unknown control direction
Authors: Mohit Mohammaderfan , Shahrokhi Mohammad , Kamalamiri Ali 
Published: June 2022

SUMMARYIn this work, an adaptive observer‐based control scheme has been designed for uncertain nonaffine nonstrict feedback systems subject to state time delay, various types of input nonlinearities, time‐varying asymmetric state constraints, and unknown control direction. Compared to the existing controllers for systems with state constraints, the designed control scheme in this work can be applied to state‐constrained systems with nonaffine structure subject to state delays, unknown control direction, and different types of input nonlinearities, while full‐states measurement is not required. Moreover, by introducing a novel saturated Nussbaum function in the present work, not only has the problem of unknown control direction been handled, but also the probability of a control shock due to applying the conventional Nussbaum functions has been eliminated. The system unknown dynamics has been approximated by using neural networks (NNs), and by updating the maximum norm of NNs weight vectors, only one adaptive law is required for the controller implementation. By employing appropriate Lyapunov functions, it has been shown that all signals in the closed‐loop system are bounded, state constraints are satisfied, and the output tracking error can be made small by selecting appropriate design parameters. The effectiveness of the designed control scheme has been shown through two simulation studies. Moreover, the superiority of the proposed saturated Nussbaum function in comparison with conventional Nussbaum functions has been shown via simulation.
A Skin‐Inspired Design Integrating Mechano–Chemical–Thermal Robustness into Superhydrophobic Coatings
Authors: Zhang Hailong , Bu Xinyu , Li Wanbo , Cui Miaomiao , Ji Xingxiang , Tao Furong , Gai Ligang , Jiang Haihui , Liu Libin , Wang Zuankai 
Published: June 2022

AbstractDesigning scalable coatings with a wide spectrum of functions such as liquid repellency, anticorrosion, and antiflaming and a high level of mechano–chemical–thermal robustness is crucial in real‐life applications. However, these individual functionalities and robustness are coupled together or even have conflicting requirements on the interfacial or bulky properties of materials, and thus, simultaneously integrating all these individual features into one coating has proved challenging. Herein, an integral skin‐inspired triple‐layered coating (STC) that resolves conflicting demands imposed by individual features on the structural, chemical, mechanical, and thermal properties of materials is proposed. Specifically, the rational design of multiple gradients in roughness, wetting, strength, and flame retardancy and the formation of continuous interfaces along its triple layers endow a sustained liquid repellency, anticorrosion, and flame retardancy even under harsh environments, as well as strong antiabrasion on surfaces and adhesion with the substrate. Such an all‐in‐one design enhances the durability and lifetime of coatings and reduces the maintenance and repair, thereby contributing to cost and energy saving. Together with a facile spraying fabrication process, this STC provides a feasible and sustainable strategy for constructing energy and resource‐saving materials.
Iron‐Phosphate‐Based Cathode Materials for Cost‐Effective Sodium‐Ion Batteries: Development, Challenges, and Prospects
Authors: He Liang , Li Huangxu , Ge Xiaochen , Li Shihao , Wang Xu , Wang Sha , Zhang Liuyun , Zhang Zhian 
Published: June 2022

AbstractThe progress on electrode materials over the last few years has greatly facilitated sodium‐ion batteries (SIBs) toward practical applications. Cost‐effectiveness is the key character to realize practical applications of SIBs. The iron‐based phosphate materials (IPBMs) are composed of the resource abundant and low‐cost Na–Fe–P–O system and have demonstrated intriguing sodium‐storage properties to reach this goal. Starting from NaFePO4, through compositional and structural engineering, many IPBMs have been developed in recent years. This review offers a comprehensive overview about the development of IPBMs. Crystal structure, electrochemical performance, and reaction mechanism of three main categories (phosphates, pyrophosphates, mixed polyanions) of IPBMs and their represented materials are systematically introduced. Besides, the key challenges encountered by IPBMs, including the impurity phase issue, low‐quality carbon coating, limited energy density, and random morphology are proposed. Finally, perspectives on the future development of IPBMs from intrinsic properties regulation to full battery manufacturing are highlighted in aspects of electrochemical performance enhancements, mechanism investigation, surface and electrolytes, and commercialization. It is believed that this review is timely and is of great importance to promote applications of cost‐effective sodium‐ion batteries.
Tumor Microenvironment‐Activated Nanosystem With High Aggregation and On‐Demand Degradation for Imaging‐Guided Synergistic Hydrogenothermal Therapy
Authors: Qin Yufei , Zheng Ziliang , Chen Xuejiao , Liu Qin , Ren Shilei , Zhang Weiwei , Duan Ailin , Zhang Ruiping 
Published: June 2022

AbstractPhotothermal therapy (PTT) as an emerging antitumor approach has many advantages. However, when the PTT generates localized hyperthermia to induce cell apoptosis, excess reactive oxygen species (ROS) and inflammatory cytokine release will threaten the peritumoral healthy tissues, thus it is challenging to develop efficient strategies to reduce the undesirable PTT‐mediated side effects. Herein, the authors report exploitation of hypoxia‐responsive degradation in designing a synergistic hydrogenothermal therapeutic nanosystem for ROS elimination and anti‐inflammatory action to enhance antitumor activity. The nanosystem (MA@NHC) is successfully constructed by encapsulating melanin‐nanoparticles (MNPs) and amine‐borane (AB) inside functionalized hyaluronic acid to obtain MA@NH, then capped with 4T1 cell‐membranes. Synergistic integration of the homotypic aggregation with EPR effect can improve the tumor‐targeting properties of MA@NHC. Upon specifically targeting tumor, sequentially time‐dependent MNPs and AB release can be triggered by hypoxia tumor‐microenvironment. Based on the superior NIR light‐absorption ability, widely permeated MNPs are activated for photoacoustic imaging‐guided PTT. Meanwhile, the high intra‐tumor acidity accelerates the production of H2 via AB to scavenge excess ROS and reduce PTT‐induced inflammatory responses, which can be further sped up during PTT. Remarkably, as an antioxidant and anti‐inflammatory agent, the MNPs synergize with H2 to protect peritumoral normal cells from damage.
Light Propagating in a Born–Infeld Background as Seen by an Accelerated Observer
Authors: Guzman‐Herrera Elda , Breton Nora 
Published: June 2022

AbstractThe propagation of light in the Born–Infeld (BI) background as seen by an accelerated observer is examined. In a Born–Infeld electromagnetic field, light trajectories are governed by the null geodesics of the effective optical metric. The accelerated observer is in a Rindler frame, a situation that, according to the Einstein equivalence principle, is equivalent to being in a uniform gravitational field. The phase velocity of light propagating through a purely magnetic or electric BI background is determined as measured by the Rindler observer. The BI field and the acceleration of the frame have opposite effects on the propagating light; while the intense electric or magnetic BI background decreases the velocity of light, in the accelerated frame light may exceed its velocity in vacuum. Light propagating parallel or transversal to the acceleration direction of the Rindler frame is considered. The redshift of light pulses sent from one Rindler observer to another in the BI background is also calculated.
Property‐Driven Development of Passively Permeable Macrocyclic Scaffolds Using Heterocycles**
Authors: Saunders George J. , Yudin Andrei K. 
Published: June 2022

AbstractPassive membrane permeability is a fundamental challenge in the development of bioactive macrocycles. To achieve this objective, chemists have resorted to various strategies, the most common of which is deployment of N‐methylated amino acids and/or D‐amino acids. Here we investigate the effect of heterocyclic grafts on the passive membrane permeability of macrocycles and report the structural consequences of iterative amino acid replacement by azole rings. Through stepwise substitution of amino acid residues for heterocycles, we show that lipophilicity and PAMPA permeability of a macrocycle can be vastly improved. Overall, changes in permeability do not scale linearly as more heterocycles are incorporated, underscoring the subtleties of conformation‐property relationships in this class of molecule. NMR analysis and molecular dynamics simulations provide insights into the structural consequences of the added heterocycles and these frameworks can now be applied as macrocyclic scaffolds for drug discovery.
Preparation and properties of carboxylated styrene‐butadiene rubber/flue gas desulfurization ash composites by in situ carboxylate reaction
Authors: Zhuang Wei , Shi Cheng , Wang Jinyun , Su Tong , Lin Tengfei , Lin Cong , Wu Xiao , Gao Min , Chen Hong , Su Qingfa 
Published: June 2022

AbstractFlue gas desulfurization ash (FGD) is a byproduct of flue gas desulfurization facilities. Its comprehensive utilization has attracted increasing interest. In this work, FGD is used as the reinforcing filler to improve the mechanical properties of carboxylated styrene‐butadiene rubber (XSBR). The effects of FGD on the curing characteristics, microtopography, and mechanical properties of the composites were studied. The results indicated that FGD can be uniformly dispersed in XSBR and effectively improve the mechanical properties of XSBR composites. The tensile strength of the XSBR/25FGD composite reaches 14.0 MPa, approximately 19.7% higher than that of pure XSBR. Even if the incorporation of FGD reaches 45 phr, the tensile strength is still higher than that of pure XSBR. The composites obtained a lower rate of thermal degradation than XSBR. The DMA properties of the composites may be improved by the appropriate amount of addition. This work provides a new method for making more effective use of FGD in the polymer field, which has significant economic and environmental benefits.
Role of aromatic ring spacer in homo‐coupled conjugated microporous polymers in selective CO2 separation
Authors: Mane Sachin Tanaji , Kanase D. G. , Mohite Suhas 
Published: June 2022

AbstractTo obtain high purity of natural and flue gases, the development of adsorbent with appropriate structure is of great importance. As a result, there is an urgent need to investigate the role of aromatic ring spacer in adsorbent in high CO2 capture. For this, conjugated microporous polymers (CMPs) were fabricated through homo‐coupling reaction of 1,3,5‐tribromobenzene (TBB) and 1,3,5‐triethynylbenzene (TEB). It was observed that, CMP‐A (without spacer) demonstrates high CO2 uptake over CMP‐B (with spacer). CMP‐A demonstrates CO2 uptake of 212.1 mg g−1 which is obviously higher than benchmark adsorbents under the analogous conditions. In addition, the obtained CO2 uptake is also higher than metal–organic framework (MOF) and energy‐intensive carbon‐based adsorbents. CMP‐A revealed high CO2/N2 selectivity (78.5) over CMP‐B (56.1). It was noticed that CMP‐A demonstrates excellent CO2/CH4 and CO2/N2 selectivity over CMP‐B at 273 K. This is mainly due to appropriate structure in CMP‐A (without spacer). The obtained CO2/N2 selectivity (78.5) is higher than recently reported adsorbents under the similar experimental conditions.
A Characterization of approximate decentralized fixed modes of time‐delay systems
Authors: Erol Hüseyin Ersin , İftar Altuğ 
Published: June 2022

AbstractThe concept of decentralized fixed mode (DFM) is crucial in determining the output feedback stabilizability by linear time‐invariant (LTI) decentralized controllers. However, in some cases, although a system has no DFMs, some of its modes may be very close to being fixed. It is thus important to characterize these modes, which are called approximate DFMs (ADFMs). In this paper, the characterization of ADFMs is discussed for LTI neutral (possibly descriptor‐type) time‐delay systems under static and dynamic decentralized output feedback control laws, and a mode mobility measure is proposed to provide quantitative information about ADFMs. To analytically compare the proposed measure, some of the commonly used quantitative measures for the characterization of ADFMs of finite‐dimensional systems have also been extended to the considered type of systems. The herein proposed approach allows multiple time delays and does not require additional expansions or preliminaries for multi‐input multi‐output systems, like some other commonly used methods. Thus, characterization with this measure, in general, requires less computational load, while it can provide more explicit information about the controller effort than the other considered measures.
Der Argentinienknoten – komplexe Infrastruktur mit BIM im Griff
Authors: Middendorf Julia , Opitz Daniel , Rahn Gunnar , Zehetmaier Gerhard , Marbes Marcel 
Published: June 2022

AbstractDer Argentinienknoten ist ein zentraler Verkehrsknoten der Haupthafenroute im Hamburger Hafen, liegt in der Verlängerung der Köhlbrandbrücke und hat essenzielle Bedeutung für die Hafenlogistik. Der Knoten besteht heute aus einer Vielzahl voneinander abhängiger Einzelbauwerke und vereint Hafenverkehr auf Straße, Schiene und Wasserstraße. Dem Ersatzneubau von Teilen des Knotens widmet sich eine Machbarkeitsstudie, die vom Auftraggeber als rein modellbasierte Studie auf Basis der Building‐Information‐Modelling‐(BIM‐)Methode konzipiert wurde. Im vorliegenden Beitrag werden die wesentlichen Aspekte der Studie beschrieben. Den Schlüssel zur Betrachtung möglicher Neu‐ und Rückbauszenarien bildet ein Bestandsmodell als Datendrehscheibe. Auf dem Bestandsmodell setzt eine umfangreiche Variantenuntersuchung auf, die in jedem Bauzustand die komplexen Abhängigkeiten der Infrastrukturen berücksichtigen muss. Vor diesem Hintergrund wird die notwendige Modellierungstiefe im Vergleich zu einer hinreichenden Aussagekraft der Variantenmodelle diskutiert. Die Studie mündet in einer Untersuchung der Vorzugsvariante mit modellbasierter Termin‐ und Logistikplanung und Visualisierung der Bauphasen zur zielgruppengerechten Ansprache der Entscheidungsebenen. Das Potenzial der BIM‐Methode zeigt sich nicht zuletzt im vollständig modellbasierten Planen – für die Studie und die damit verbundenen Abstimmungen zwischen Planer, Bauherr und Dritten wurde nicht ein herkömmlicher Plan angefertigt.