bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytohormone abscisic acid elicits positive effects on harmaline‐induced cognitive and motor disturbances in a rat model of essential tremor
Authors: Shabani Mohammad , Naderi Reyhaneh 
Published: April 2022

AbstractObjectiveEssential tremor (ET) as a neurological disorder is accompanied by cognitive and motor disturbances. Despite the high incidence of ET, the drug treatment of ET remains unsatisfactory. Recently, abscisic acid (ABA) has been reported to have positive neurophysiological effects in mammals. Here, the effects of ABA on harmaline‐induced motor and cognitive impairments were investigated in rats.MethodsMale Wistar rats weighing 120–140 g were divided into control, harmaline (30 mg/kg, ip), ABA vehicle (DMSO+normal saline), and ABA (10 μg/rat, icv, 30 min before harmaline injection) groups. Exploratory, balance and motor performance, anxiety, and cognitive function were assessed using footprint, open field, wire grip, rotarod, and shuttle box tests.ResultsThe results indicated that ABA (10 μg/rat) can improve harmaline‐induced tremor in rats. The administration of ABA significantly increased time spent on wire grip and rotarod. In addition, ABA had a promising effect against the cognitive impairments induced by harmaline.ConclusionTaken together, ABA has positive effects on locomotor and cognitive impairments induced by tremor. However, further studies are required to determine the exact mechanisms of ABA on the ET.
Domperidone‐induced pityriasis rosea‐like drug eruption
Authors: Saad Sarra , Gammoudi Rima , Abdessayed Nihed , Denguezli Mohamed 
Published: April 2022

AbstractPityriasis rosea is a common, acute, self limiting inflammatory skin disease. Pityriasis rosea‐like eruptions (PR‐LE) have been reported after drugs. The clinical presentation of PR‐LE can be distinguished from pityriasis rosea. We reporte a 41‐year‐old woman who developed PR‐LE 5 days after administration domperidone.
Euglycemic diabetic ketoacidosis in pregnancy with COVID‐19: A case report and literature review
Authors: Wazir Sameena , Shittu Saheed , Dukhan Khaled , Sharief Maram , Beer Stephen , Malik Waseem , Alansari Lolwa 
Published: April 2022

AbstractDiabetic ketoacidosis (DKA) is a life‐threatening complication of diabetes and is considered a medical emergency. Euglycemic DKA (EKDA) is a variant of DKA with a normal or minimally elevated glucose level <200 mg/dl. The condition can be difficult to diagnose due to the relatively normal glucose levels. Pregnancy, infection, and a low‐calorie intake are some of the contributing common etiologies of EDKA. Despite a rapid increase in scientific publications on COVID‐19, there are still knowledge gaps regarding the course of COVID‐19 in some patient subset. This is especially the case for pregnant women. In this case report, we discuss the course of COVID‐19 infection in a pregnant woman with gestational diabetes who developed severe euglycemic diabetic ketoacidosis triggered by various precipitating factors, including starvation, caused by COVID‐19 infection and its gastrointestinal effects.
Boron Modified Cu/Al2O3 Catalysts for the Selective Reductive Amination of Levulinic Acid to N‐Substituted Pyrrolidinones
Authors: Zeng Yuyao , Wang Bowei , Yan Fanyong , Xu Wensheng , Bai Guoyi , Li Yang , Yan Xilong , Chen Ligong 
Published: April 2022

AbstractThe reductive amination of biomass‐derived levulinic acid (LA) to value‐added N‐substituted pyrrolidinones with amine and molecular hydrogen over heterogeneous catalyst represents an atom‐economical and scalable route. In this paper, a series of boron doped Cu/Al2O3 catalysts via kneading and impregnation method are developed for the continuous reductive amination of LA. Compared with Cu/Al2O3, Cu10/AlB3O catalyst exhibits greatly improved catalytic performance for this reaction at low operation temperature. Structure‐property correlation investigations were performed with diverse characterization methods, and the results revealed that the excellent catalytic performance of boron doped Cu/Al2O3 catalysts was mainly attributed to the synergistic effect of its well‐dispersed Cu nanoparticles, appropriate surface Cu electronic state and surface acidic sites nearby. Besides, Cu10/AlB3O shows great stability during the reaction over 200 h. This work provides a low‐cost, efficient and environmentally friendly heterogeneous catalytic system for the continuous production of N‐substituted pyrrolidinones.
Two‐Dimensional Nitrogen‐Doped Ti3C2 Promoted Catalysis Performance of Silver Nanozyme for Ultrasensitive Detection of Hydrogen Peroxide
Authors: Zhu Beibei , An Dong , Bi Zhaoshun , Liu Wen , Shan Wei , Li Yonghai , Nie Guohui , Xie Ni , Al‐Hartomy Omar A. , Al‐Ghamdi Ahmed , Wageh Swelm. , Chen Wen , Bao Xichang , Gao Xiang , Zhang Han , Qiu Meng 
Published: April 2022

AbstractSilver nanoparticles (AgNPs)‐based nanozyme sensors are gaining attention for rapid on‐site H2O2 detection, which is beneficial to disease diagnosis and environmental monitoring. However, the severe agglomeration of AgNPs on the electrodes significantly reduced electrochemical catalytic activity. In this work, we fabricated N‐doped Ti3C2 MXene (named Ag/N−Ti3C2) deposited with three‐dimensional flower‐like AgNPs to achieve ultrasensitive H2O2 detection. N doping strategy is employed to improve the conductivity of MXene, and the corresponding catalytic activity of Ag/N−Ti3C2 is enhanced by optimizing the growth process and morphology. The Ag/N−Ti3C2/glassy carbon electrode (Ag/N‐Ti3C2/GCE) sensor exhibited a wide H2O2 detection range (0.05–35 mM), a low limit detection (1.53 μM), and 3.1 % relative standard deviation in 50 repeated cyclic voltammetry measurements. The results above indicate that catalytic activity of metal nanozymes could be influenced by the substrate and both materials jointly determine the sensor's performance. As a result, N‐doped MXene is an attractive candidate for biological sensing and other electrocatalytic applications.
Conditional survival and long‐term efficacy with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma
Authors: Motzer Robert J. , McDermott David F. , Escudier Bernard , Burotto Mauricio , Choueiri Toni K. , Hammers Hans J. , Barthélémy Philippe , Plimack Elizabeth R. , Porta Camillo , George Saby , Powles Thomas , Donskov Frede , Gurney Howard , Kollmannsberger Christian K. , Grimm Marc‐Oliver , Barrios Carlos , Tomita Yoshihiko , Castellano Daniel , Grünwald Viktor , Rini Brian I. , McHenry M. Brent , Lee Chung‐Wei , McCarthy Jennifer , Ejzykowicz Flavia , Tannir Nizar M. 
Published: April 2022

BackgroundConditional survival estimates provide critical prognostic information for patients with advanced renal cell carcinoma (aRCC). Efficacy, safety, and conditional survival outcomes were assessed in CheckMate 214 (ClinicalTrials.gov identifier NCT02231749) with a minimum follow‐up of 5 years.MethodsPatients with untreated aRCC were randomized to receive nivolumab (NIVO) (3 mg/kg) plus ipilimumab (IPI) (1 mg/kg) every 3 weeks for 4 cycles, then either NIVO monotherapy or sunitinib (SUN) (50 mg) daily (four 6‐week cycles). Efficacy was assessed in intent‐to‐treat, International Metastatic Renal Cell Carcinoma Database Consortium intermediate‐risk/poor‐risk, and favorable‐risk populations. Conditional survival outcomes (the probability of remaining alive, progression free, or in response 2 years beyond a specified landmark) were analyzed.ResultsThe median follow‐up was 67.7 months; overall survival (median, 55.7 vs 38.4 months; hazard ratio, 0.72), progression‐free survival (median, 12.3 vs 12.3 months; hazard ratio, 0.86), and objective response (39.3% vs 32.4%) benefits were maintained with NIVO+IPI versus SUN, respectively, in intent‐to‐treat patients (N = 550 vs 546). Point estimates for 2‐year conditional overall survival beyond the 3‐year landmark were higher with NIVO+IPI versus SUN (intent‐to‐treat patients, 81% vs 72%; intermediate‐risk/poor‐risk patients, 79% vs 72%; favorable‐risk patients, 85% vs 72%). Conditional progression‐free survival and response point estimates were also higher beyond 3 years with NIVO+IPI. Point estimates for conditional overall survival were higher or remained steady at each subsequent year of survival with NIVO+IPI in patients stratified by tumor programmed death ligand 1 expression, grade ≥3 immune‐mediated adverse event experience, body mass index, and age.ConclusionsDurable clinical benefits were observed with NIVO+IPI versus SUN at 5 years, the longest phase 3 follow‐up for a first‐line checkpoint inhibitor‐based combination in patients with aRCC. Conditional estimates indicate that most patients who remained alive or in response with NIVO+IPI at 3 years remained so at 5 years.
C−C Coupling of Aryl Chlorides and Reduction of Nitroarenes to Amines Employing Recyclable Heterogeneous Green Catalysts
Authors: Manna Krishna , Suresh Kumar Basuvaraj , Maity Tanmoy , Natarajan Srinivasan 
Published: April 2022

AbstractTwo new isostructural inorganic coordination polymers, [M(C14H8O6)(C10H8N2)2H2O)] ⋅ (C3H7NO), (M=Co, Ni) were prepared employing 2, 5‐bis(prop‐2‐yn‐1‐yloxy)terephthalic acid (2,5 BPTA) and 4,4′ bipyridine as ligands. The connectivity between the metal‐centers and the ligands give rise to a two‐dimensional layer structure. The Ni‐containing one has higher stability compared to the Co‐containing one. The Co‐containing compound, 1, was heated in Ar‐atmosphere to prepare Co‐nanoparticles, supported over graphitic carbon. The Co@C−T compounds were found to be active for the Bechamp reaction of reduction of nitroarenes to aminoarenes under solvent‐free condition with good yields and recyclability. The Ni‐containing compound, 2 was loaded with Pd‐nanoparticles by known procedures. The Pd@2 samples were found to be a good catalyst for the Suzuki‐Miyaura C−C coupling of chloroarenes in ethanol at 75 °C in good yield. The present work demonstrates a clean approach for the preparation of new heterogeneous catalysts for the reduction of nitroarenes and especially towards activating chloro‐arenes under recyclable reaction conditions. These catalysts and the reactions are green as the Bechamp reaction employing the Co@C−T catalysts was carried out under solvent‐free conditions and the Pd@2 catalysis employing environmentally benign ethanol.
Early detection of digital mammogram using kernel extreme learning machine
Authors: Bacha Sawcen , Ben Abdellafou Khawla , Aljuhani Ahamed , Taouali Okba , Liouane Noureddine 
Published: April 2022

AbstractAn automated computer‐assisted medical diagnosis that combines latest medical approaches and the advanced machine learning algorithms is a very crucial multidisciplinary technology, generating correct and noninvasive diagnoses of multiple diseases like breast cancer. The work proposed in this article focuses on the development of a biomedical computer‐assisted diagnosis model that can classify digital mammography as normal (healthy) or abnormal, and further, as malignant or benign. The proposed approach employs the discrete Chebyshev transform to extract the features. Then, the kernel principal component analysis technique is used to extract the discriminating features from the original feature vector. Subsequently, an optimized kernel extreme learning machine is proposed as a classifier to detect the tumors present in the mammographic images. Because the efficiency of the proposed classifier depends on its characteristic kernel variable, the main idea of the present work is to choose the most appropriate features from the downsized feature set and simultaneously obtain the optimized value of the aforementioned parameter. To validate the efficiency of the proposed work, the proposed scheme is performed on two publicly available data sets, namely the Mammographic Image Analysis Society data set and the INbreast data set. From the experimental analysis and its results, it is showed that for both normal–abnormal and malignant–benign classification, the proposed approach results in accuracy of 100% for the first data set. However, in the case of malignant–benign classification, the proposed approach gives an accuracy of 99.93% for the second data set. Further, it is also observed that the proposed approach exhibits highest performance as compared to that of the other approaches. Additionally, the ANOVA test is evaluated to demonstrate that the achievement of the proposed approach is significantly good than that of the other existing approaches.
The mediating effect of stock price crash risk on the relationship between corporate social responsibility and cost of equity moderated by state ownership: Moderated‐mediation analysis
Authors: Thuy Cao Thi Mien , Khuong Nguyen Vinh , Canh Nguyen Thi , Liem Nguyen Thanh 
Published: April 2022

AbstractThis paper investigates the roles that stock price crash risk and state ownership play in the relationship between CSR disclosure and cost of equity capital (COE). The research sample comprises 225 listed firms in Vietnam. We use GMM estimation technique and Sobel test to test the empirical hypotheses. To begin with, there is a complementary mediation effect of stock price crash risk in the relationship between CSR disclosure and COE. Notably, our study is the first empirical one to confirm that stock price crash risk serves as an intermediate in the above relationship. Second, state ownership strengthens the negative impact of CSR disclosure on COE significantly. The paper offers insight into how stock price crash risk and state ownership affect the merit of CSR disclosure towards firms' COE and how the lack of consideration of such factors could be the reason for the inconsistent findings in the previous studies.
Inhibition of CXXC5 function reverses obesity‐related metabolic diseases
Authors: Seo Seol Hwa , Kim Eunhwan , Lee Soung‐Hoon , Lee Yong‐ho , Han Dai Hoon , Go Hyesun , Seong Je Kyung , Choi Kang‐Yell 
Published: April 2022

AbstractBackgroundMetabolic diseases, including type 2 diabetes, have long been considered incurable, chronic conditions resulting from a variety of pathological conditions in obese patients. Growing evidence suggests the Wnt/β‐catenin pathway is a major pathway in adipose tissue remodelling, pancreatic β‐cell regeneration and energy expenditure through regulation of key metabolic target genes in various tissues. CXXC5‐type zinc finger protein 5 (CXXC5) is identified negative feedback regulator of the Wnt/β‐catenin pathway that functions via Dishevelled (Dvl) binding.MethodsExpression level of CXXC5 was characterised in clinical samples and diabetes‐induced mice model. Diabetes‐induced mice model was established by using high‐fat diet (HFD). HFD‐fed mice treated with KY19334, a small molecule inhibiting CXXC5‐Dvl protein–protein interaction (PPI), was used to assess the role of CXXC5 in metabolic diseases.ResultsHere, we show that CXXC5 is overexpressed with suppression of Wnt/β‐catenin signalling in visceral adipose tissues of patients with obesity‐related diabetes. Meanwhile, Cxxc5−/− mice fed an HFD exhibited resistance to metabolic dysregulation. KY19334 restores the lowered Wnt/β‐catenin signalling and reverses metabolic abnormalities as observed in HFD‐fed Cxxc5−/− mice. Administration of KY19334 on HFD‐fed mice had a long‐lasting glucose‐controlling effect through remodelling of adipocytes and regeneration of pancreatic β‐cells.ConclusionOverall, the inhibition of CXXC5 function by small molecule‐mediated interference of Dvl binding is a potential therapeutic strategy for the treatment of obesity‐related diabetes.
Zooplankton recovery from a whole‐lake disturbance: Examining roles of abiotic factors, biotic interactions, and traits
Authors: McGann Brian N. , Strecker Angela L. 
Published: April 2022

AbstractCommunity assembly following disturbance is a key process in determining the composition and function of the future community. However, replicated studies of community assembly at whole‐ecosystem scales are rare. Here, we describe a series of whole‐lake experiments, in which the recovery of zooplankton communities was tracked following an ecosystem‐scale disturbance, that is, application of the piscicide, rotenone. Using a before‐after‐control‐impact design, 14 lakes in eastern Washington were studied: Seven lakes were treated with rotenone, while seven lakes acted as reference systems. Each lake was monitored up to 6 months before and 1–2 years after the rotenone treatments. Zooplankton samples and environmental measurements were collected approximately monthly from each lake. Community responses following disturbance were assessed using metrics of abundance, diversity, and community composition, as well as taxonomic group abundance. Zooplankton recovery was also assessed using species traits related to habitat, feeding mode, trophic level, body size, and life history. In addition to patterns of recovery, potential mechanisms were explored relating to abiotic conditions, biotic interactions, and traits. There were steep declines in the abundance (average across years: 99%) and diversity (average across years: 75%) of the zooplankton community following rotenone treatment. Although abundance had recovered by the second year of the study, community diversity had not fully recovered after 2 years. Communities from rotenone lakes appeared to be compositionally recovered within about 8 months following disturbance. Cyclopoid copepods were typically the first group to recover and remained dominant for a few months, whereas cladocerans recovered more slowly, typically within ~6–7 months following rotenone. Calanoid copepods were not fully recovered 2 years after rotenone treatment. Traits related to body size and feeding mode were associated with the zooplankton communities following rotenone treatment. We failed to observe significant spatial synchrony in recovery patterns of zooplankton across lakes, though we did observe significant synchrony of zooplankton taxonomic groups within lakes. These findings suggest that traits related to ecological function, and to a lesser extent, biotic, and abiotic factors, as well as characteristics of the disturbance itself, may be important in helping to understand recovery processes.
Antibacterial interactions of pulegone and 1,8‐cineole with monolaurin ornisin against Staphylococcus aureus
Authors: Farhanghi Ali , Aliakbarlu Javad , Tajik Hossein , Mortazavi Negar , Manafi Leila , Jalilzadeh‐Amin Ghader 
Published: April 2022

AbstractThe aim of this study was to investigate the antibacterial interactions of pulegone and 1,8‐cineole with monolaurin ornisin against Staphylococcus aureus. The individual and combined antibacterial activities of the compounds were evaluated using minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), fractional inhibitory concentration index (FICi), and time‐kill methods. Furthermore, the mechanism of the antibacterial action of the compounds was tested by measuring the release of cell constituents. The MIC values of pulegone, 1,8‐cineole, nisin, and monolaurin were 5.85 µl/ml, 23.43 µl/ml, 6.25 µg/ml, and 0.031 mg/ml, respectively. A synergistic antibacterial activity (FICi = 0.5) was found between 1,8‐cineole and nisin. The time‐kill assay showed that the populations of S. aureus exposed to 1,8‐cineole, nisin, and their combination were decreased by 5.9, 5.3, and 7.1 log CFU (colony‐forming units)/mL, respectively. The combination of 1,8‐cineole and nisin also induced the highest release of cell constituents. It was concluded that the combination of 1,8‐cineole and nisin could be considered as a novel and promising combination which may reduce the required dose of each antibacterial compound.
The effect of roasting, storage temperature, and ethanoic basil (Ocimum basilicum L.) extract on the oxidative stability of crude sesame (Sesamum indicum L.) oil
Authors: Gebremeskel Abrehet F. , Ngoda Peninah N. , Kamau‐Mbuthia Elizabeth W. , Mahungu Symon M. 
Published: April 2022

AbstractSesame (Sesamum indicum L.) is an annual oilseed crop that is widely used for crude sesame oil (CSO) extraction. CSO is unrefined, thus, may impact the storage stability due to the uncontrolled processing and handling conditions, and absence of preservatives. The purpose of this study intends to analyze the fatty acid profile and oxidative stability of CSO. In a complete randomized (2*2*2) factorial design, clean sesame seeds (3.92% moisture content) were used for oil extraction with/without roasting treatment (200°C). The fatty acid profile and oxidative value of the CSO were analyzed. The roasted sesame seed oil extraction yield was higher (50.9%) and composed of 83.15% unsaturated fatty acids with an omega‐6 to omega‐3 ratio of 95.3. The ratio of polyunsaturated fatty acids (PUFAs) to saturated fatty acids (SFAs) was 2.9, while the moisture content of the CSO was 0.37%, exceeding the tolerable limit. The predominant fatty acids of CSO include palmitic, stearic, oleic, and linoleic acids. Elevated thermal condition during processing and handling speeding up oxidation exceeded the tolerable limit after 25 days of storage, while the ethanoic basil extract was found to inhibit oxidation in the range of 16.38%–90% (p‐value < .05). The peroxide value (PV), para‐anisidine value (p‐AV), and total oxidation (TOTOX) value of CSO with 50 ppm (parts per million) basil extract were detected within the range of 0.29–3.92, 0.75–2.59, and 1.57–8.6 milliequivalents (meq) O2/kg oil, respectively, below the tolerable limit. Nevertheless, basil extract's antioxidant property was declined during prolonged storage, in particular, at elevated temperature. The use of organic extracts of locally available sweet basil herb is capable of mitigating oxidation and substituting inorganic antioxidant for a healthier diet.
CO2 absorption and microwave regeneration with high‐concentration TETA nonaqueous absorbents
Authors: Li Jinxiu , Li Yu , Li Chen , Tu Rui , Xie Pengfei , He Yi , Shi Yao 
Published: April 2022

AbstractWhile nonaqueous organic‐amine absorbents have great potential in reducing energy consumption of CO2 capture, their absorption/desorption behaviors are still poorly understood when high‐concentration polyamines are used. On the other hand, large scale CO2 capture demands the use of high‐concentration polyamines absorbents. Therefore, we investigated the absorption and microwave regeneration behavior of high‐concentration triethylenetetramine (TETA) in three typical organic solvents, including polyethylene glycol 200 (PEG200), diethylene glycol (DEG), and ethylene glycol (EG). The results showed that high‐concentration TETA nonaqueous absorbents demonstrate advantages in absorption rate and regeneration energy consumption. The average absorption rate of 2.0 and 5.0 mol/L TETA/EG was 2.84 and 4.70 times that of 0.6 mol/L, respectively. The energy consumption of TETA/EG and TETA/DEG decreased by 29.4 and 25.6% as the concentration increased from 0.6 to 5.0 mol/L. In addition, the high‐concentration TETA/PEG200 absorbent demonstrated observable tolerance for water vapor, which usually exists in flue gas. Results also showed that microwave regeneration was superior to conventional conduction heating especially when high‐concentration TETA/PEG200 absorbent were used. The energy consumption of microwave regeneration of the absorbent with a concentration of 0.6, 2.0, and 5.0 mol/L was reduced by 65.9, 81.2, and 86.0%, respectively when compared with conduction heating. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.