bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive, complicated, distant, and negative: How different teacher‐student relationship profiles relate to students’ science motivation
Authors: Burns Emma C. , Van Bergen Penny , Leonard Annie , Amin Yusriya 
Published: September 2022

AbstractIntroductionResearchers note a consistent decline in adolescents’ motivation and participation in science. It is important to examine factors vital to students’ motivation in science, such as teacher‐student relationships (TSRs). Limited research in science has examined TSRs from a multidimensional or person‐centered perspective. The present investigation adopts Ang's tripartite relational framework to examine three dimensions of TSRs: socio‐emotional support, instrumental help, and conflict. Such research is needed to better understand the diversity of relationships that exist within a science classroom and their impact on science motivation.MethodsThis study examined N = 2669 Australian high school students (66% girls; Mage = 15.11 years; SD = 0.69). Data were collected via online sampling in the final quarter of 2020. The data are cross‐sectional. Latent profile analysis was used to (1) determine if distinct student profiles based on the three dimensions of TSRs existed and (2) the extent to which these profiles were associated with varying levels of science motivation: self‐efficacy, intrinsic value, utility value, and cost.ResultsFour distinct profiles were identified: Positive, Complicated, Distant, and Negative. Students in the Negative TSR profile reported the lowest adaptive motivation and highest cost. The associations between profile membership and motivation were more varied for the Positive, Complicated, and Distant TSR profiles.ConclusionsFindings indicate that dichotomous perspectives (positive vs. negative) may be insufficient to describe the diversity of relationships within science classrooms. Results also suggest that concurrent attendance to all dimensions of TSRs is needed to improve relationships.
Workplace heterogeneity and wage inequality in Denmark
Authors: Morin Annaïg 
Published: September 2022

SummaryWage inequality is on the rise in most developed economies, and this phenomenon has fostered a growing body of research on its potential drivers. Using German data over the period 1985–2009, Card et al. (The Quarterly Journal of Economics 2013, 128(3), 967‐1015) argue that rising workplace heterogeneity has contributed substantially to the rise in wage inequality. I revisit their findings in two ways. First, because the generalization of their findings remains an open question, I apply their methodological approach to Danish register data and test whether rising workplace heterogeneity explains a significant share of the rise in wage inequality in Denmark. I find that, contrary to Germany, workplace heterogeneity remained practically stable over time, and this pattern contributed slightly negatively to the rise in wage inequality. Second, I complement Card et al.'s (2013) methods with the variance decomposition exercise proposed by Song et al. (2019) to identify more precisely the sources of the rise in wage inequality in Denmark. Although the rise in wage inequality is partly a between‐establishment phenomenon, I show that the strengthening of assortative matching patterns and the rising heterogeneity of workers within establishments are the main drivers of growing inequality.
Retracted: Britannin mediates apoptosis and glycolysis of T‐cell lymphoblastic lymphoma cells by AMPK‐dependent autophagy
Authors: Hong Haoyuan , Luo Bin , Xie Zucheng , Li Meiwei , Xu Qingyuan , He Zhendong , Peng Zhigang 
Published: September 2022

AbstractThe above article, published online on 19 September 2022 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.23211), has been retracted by agreement between the authors, the journal Editor in Chief, Hari Bhat, and Wiley Periodicals, LLC.The article is being retracted at the authors' request because some of the data underlying this article refer to a different cell line from the one reported in it. As a result, the article's conclusions do not accurately reflect the full data and cannot be considered reliable.
Enhancing the bioconversion of ferulic acid from alkaline hydrolysate of corn cobs to vanillin by Amycolatopsis thermoflava under nutrient limitation and reducing sugar control
Authors: Nirwana Wa Ode Cakra , Hung I‐Hsuan , Shu Chin‐Hang 
Published: September 2022

AbstractBACKGROUNDThe use of commercially available ferulic acid (FA) as a precursor for vanillin production is costly. The utilization of agro‐waste as a starting material provides an alternative to obtain FA at a low cost and establish an economically profitable production system. In this work, optimization of ultrasound‐assisted extraction conditions for releasing FA from corn cobs using alkaline treatment was conducted. Further, bioconversion of FA from the crude hydrolysate of corn cobs to vanillin using Amycolatopsis thermoflava was performed.RESULTSSince autoclaved hydrolysate was unfavorable for cell growth and vanillin formation, pasteurization was proposed. However, the presence of contaminants limited the entire process. Aiming to suppress the growth of contaminants and increase vanillin yield, novel strategies of limiting and controlling the nutrients for the strain were developed. Optimal hydrolysis conditions (NaOH concentration = 0.5 M, solid loading = 10% for 30 min) produced hydrolysate with relatively high titers of FA (715 mg L−1) and p‐coumaric acid (1025 mg L−1). To improve vanillin production from FA, four parameters (including the effects of sterilization method, nutrient limitation, initial biomass concentration, and reducing sugar control) were investigated. By adopting these strategies and performing bioconversion of FA to vanillin with an initial biomass concentration of 1.5 g L−1, the yield of vanillin was significantly increased by 29.5‐fold to 477.4 mg g−1, compared to bioconversion using autoclaved hydrolysate.CONCLUSIONThis approach represents a relatively economical method for vanillin production from agro‐waste because it uses crude hydrolysate, requires minimum nutrients, and involves non‐modified organisms with a relatively short bioconversion time (17 h). © 2022 Society of Chemical Industry (SCI).
Perspectives on Spanish language concordant cancer genetic counseling sessions from the Spanish‐speaking population
Authors: Jimenez Sharisse , Matthews Anne , Darrah Rebecca , Schreiber Allison , Ricker Charité , Wolfe Schneider Kami 
Published: September 2022

AbstractGenetic counselors (GCs) provide risk assessment, education, and counseling about the genetic contribution to disease. To do so, they must effectively communicate, build rapport, and help patients make the best decisions for themselves and their families. Language barriers add a complex layer to this patient‐provider dynamic. While interpreters serve as a primary solution when a patient and GC speak different languages, issues have been documented with these sessions, such as misinterpreted genetic terminology (Gutierrez et al., 2017). Having a GC with concordant language skills may help address these barriers. The purpose of this study was to assess Spanish‐speaking patients' perspectives on communication, decision‐making, and the interpersonal relationship developed with a bilingual GC in language concordant cancer genetic counseling sessions. Spanish‐speaking patients, ages 18 or older, seen by a Spanish‐speaking GC at a California public, safety‐net hospital were eligible to participate in this study. Nine participants were interviewed via telephone by the bilingual researcher using a semi‐structured interview guide to assess three domains: communication, decision‐making, and interpersonal relationship. Analyses of interview transcripts identified themes within these three areas of focus: (1) participants felt all explanations were clear and they were not afraid to ask questions in the session, (2) participants experienced preference‐concordant decision making, and (3) participants felt empowered and supported by the GC. Participants suggested that GCs working with Spanish‐speaking patients in the future should consider group counseling sessions, engaging in outreach efforts to educate the Spanish‐speaking community about genetics, and increasing the number of GCs who speak Spanish. These results demonstrate the positive experiences of Spanish‐speaking patients in language concordant cancer genetic counseling sessions and further support the need for recruitment of Spanish‐speaking individuals into the profession. Future research should further assess the experience of Spanish‐speaking patients in language concordant sessions and address the role of cultural concordance in sessions.
Spanning eulerian subdigraphs in semicomplete digraphs
Authors: Bang‐Jensen Jørgen , Havet Frédéric , Yeo Anders 
Published: September 2022

AbstractA digraph is eulerian if it is connected and every vertex has its in‐degree equal to its out‐degree. Having a spanning eulerian subdigraph is thus a weakening of having a hamiltonian cycle. In this paper, we first characterize the pairs of a semicomplete digraph and an arc such that has a spanning eulerian subdigraph containing . In particular, we show that if is 2‐arc‐strong, then every arc is contained in a spanning eulerian subdigraph. We then characterize the pairs of a semicomplete digraph and an arc such that has a spanning eulerian subdigraph avoiding . In particular, we prove that every 2‐arc‐strong semicomplete digraph has a spanning eulerian subdigraph avoiding any prescribed arc. We also prove the existence of a (minimum) function such that every ‐arc‐strong semicomplete digraph contains a spanning eulerian subdigraph avoiding any prescribed set of arcs. We conjecture that and establish this conjecture for and when the arcs that we delete form a forest of stars. A digraph is eulerian‐connected if for any two distinct vertices , the digraph has a spanning ‐trail. We prove that every 2‐arc‐strong semicomplete digraph is eulerian‐connected. All our results may be seen as arc analogues of well‐known results on hamiltonian paths and cycles in semicomplete digraphs.
Edge coloring graphs with large minimum degree
Authors: Plantholt Michael J. , Shan Songling 
Published: September 2022

AbstractLet be a simple graph with maximum degree . A subgraph of is overfull if Chetwynd and Hilton in 1986 conjectured that a graph with has chromatic index if and only if contains no overfull subgraph. The best previous results supporting this conjecture have been obtained for regular graphs. For example, Perković and Reed verified the conjecture for large regular graphs with degree arbitrarily close to . We provide a similar result for general graphs asymptotically, showing that for any given , there exists a positive integer such that the following statement holds: if is a graph on vertices with minimum degree at least , then has chromatic index if and only if contains no overfull subgraph.
De‐escalation or discontinuation of tyrosine kinase inhibitor in patients with chronic myeloid leukemia: A multicentral, open‐label, prospective trial in China
Authors: Luo Jie , Du Xin , Lou Jin , Wu Jianwei , Ma Liping , Huang Jixian , Wang Liangtuo , Tu Chuanqing , Liu Zelin , Chen Liya , Tan Yaxian , Luo Dongmei , Liang Hanyin , Yin Changxin , Cao Rui , Zhou Xuan , Liu Qifa , Liu Xiaoli , Xu Na 
Published: September 2022

AbstractBackground: Long‐term treatment‐free remission (TFR) represents a new goal for chronic myeloid leukemia (CML). Optimizing dose of tyrosine kinase inhibitors (TKIs) in the CML treatment maybe a new challenge to maintain effective and improving patients’ quality of life. We hypothesized that administration of low‐dose TKIs does not compromise major molecular response (MMR) in patients with CML who have a deep molecular response (DMR).Methods: We did an open‐label, randomized trial at eight hospitals in China. Eligible CML‐CP patients (aged 18–70 years) had shown continuous response to TKI more than 5 years and maintained MR4.5 (BCR‐ABLIS ≤ 0.0032%) in recent 18 months. Patients were randomly assigned (1:1) to the TKI de‐escalation group or the discontinuation group. Randomization was done with permuted blocks (block size four) and implemented through an interactive web‐based randomization system. Recurrence was defined as the single sample with real time Quantitative PCR (RT‐qPCR) measurement greater than 0.1% (MMR). The primary endpoint was 12‐month MMR rate in patients who received de‐escalation or discontinuation of TKIs. This study was registered at ClinicalTrials.gov (NCT04143087).Results: Around 125 patients were enrolled between October 23, 2019 and October 31, 2020, 62 patients received dose de‐escalation of TKIs, while 63 patients in the discontinuation group. In the de‐escalation group, molecular recurrence‐free survival at 12 months was 88.32% (95% CI 79%–98%), whereas molecular recurrence‐free survival in the discontinuation group at 12 months was 59.98% (95% CI 47–73). No progressions occurred at the data cut‐off date. All 29 recurrence cases restart TKI treatment returned to MMR. Cytolytic NK cells as a proportion of lymphocyte cells were significantly increased from baseline after 6 months whether in the de‐escalation or TKIs cessation group (P = 0.048, 0.001, respectively); compared with the relapsing patients, Tregs proportion was decreased (P = 0.003), and higher proportion of NK cells were found in non‐relapsing patients whether in TKI de‐escalation or discontinuation group (P = 0.011, 0.007, respectively). We also found that the de‐escalation group showed better disease‐specific HRQOL in regards to its impact on emotional functioning, fatigue, pain, and financial difficulties.Conclusion: With 88.32% MMR in 12‐months follow‐up after de‐escalation TKIs’ treatment, dose‐halving could become a new treatment paradigm for CML patients who with DMR under continuing maintenance therapy with TKIs.
Early relapse prediction after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia (ALL) using lineage‐specific chimerism analysis
Authors: Lindahl Hannes , Valentini Davide , Vonlanthen Sofie , Sundin Mikael , Björklund Andreas T. , Mielke Stephan , Hauzenberger Dan 
Published: September 2022

AbstractRelapse is a major cause of treatment failure after hematopoietic stem cell transplantation (HSCT) for acute leukemia. Here, we report a monocentric retrospective study of all HSCTs for B cell acute lymphoblastic leukemia (ALL) performed during the years 2005–2021 (n = 138, including 51 children), aiming to identify the optimal use of lineage‐specific recipient‐donor chimerism analysis for prediction of relapse. In adults, relapse was associated with increased recipient chimerism in CD3+ bone marrow cells sampled at least 30 days before a relapse. Relapse could be predicted with a sensitivity of 73% and a specificity of 83%. Results were similar for children but with a higher recipient chimerism cutoff. Additionally, adults that had at least one chimerism value <0.12% in CD3+ peripheral blood cells within the first 60 days after HSCT had 89% probability of being relapse‐free after 2‐years compared to 64%. Results were similar for children but again necessitating a higher chimerism cutoff. These results suggest that high‐sensitive lineage‐specific chimerism analysis can be used for (1) early ALL relapse prediction by longitudinal chimerism monitoring in CD3+ bone marrow cells and (2) relapse risk stratification by analyzing CD3+ blood cells early post‐HSCT.
Cortical thickness and its relationship to cognitive performance and metabolic control in adults with phenylketonuria
Authors: Muri Raphaela , Maissen‐Abgottspon Stephanie , Rummel Christian , Rebsamen Michael , Wiest Roland , Hochuli Michel , Jansma Bernadette M. , Trepp Roman , Everts Regula 
Published: September 2022

AbstractDespite good control of phenylalanine (Phe) levels during childhood and adolescence, adults with phenylketonuria (PKU) often show abnormalities in the white matter of the brain, which have been associated with poorer cognitive performance. However, whether such a relationship exists with cortical gray matter is still unknown. Therefore, we investigated cortical thickness and surface area in adults with early‐treated PKU and their relationship to cognitive functions and metabolic control. We included 30 adult patients with early‐treated and metabolically well‐controlled PKU (median age: 35.5 years) and 54 healthy controls (median age: 29.3 years). Surface‐based morphometry was derived from T1‐weighted magnetic resonance images using FreeSurfer, and general intelligence, executive functions, and attention were assessed. Concurrent plasma Phe, tyrosine, and tryptophan levels were measured in patients. In addition, Phe levels were collected retrospectively to calculate the index of dietary control. Patients showed a thinner cortex than controls in regions of the bilateral temporal, parietal, and occipital lobes (effect size r = −0.34 to −0.42, p < 0.05). No group differences in surface area were found. In patients, accuracy in the working memory task was positively correlated with thickness in the left insula (r = 0.45, p = 0.013), left fusiform gyrus (r = 0.39, p = 0.032), and right superior temporal gyrus (r = 0.41, p = 0.024), but did not survive false discovery rate correction. Neither concurrent nor historical metabolic parameters were related to cortical thickness. Taken together, adults with PKU showed widespread reductions in cortical thickness despite good metabolic control in childhood and adolescence. However, alterations in cortical thickness were unrelated to metabolic parameters and cognitive performance.
Outcome of infantile nephropathic cystinosis depends on early intervention, not genotype: A multicenter sibling cohort study
Authors: Veys Koenraad , Zadora Ward , Hohenfellner Katharina , Bockenhauer Detlef , Janssen Mirian C. H. , Niaudet Patrick , Servais Aude , Topaloglu Rezan , Besouw Martine , Novo Robert , Haffner Dieter , Kanzelmeyer Nele , Pape Lars , Wühl Elke , Harms Erik , Awan Atif , Sikora Przemyslaw , Ariceta Gema , van den Heuvel Bert , Levtchenko Elena 
Published: September 2022

AbstractInfantile nephropathic cystinosis (INC) is an inheritable lysosomal storage disorder characterized by lysosomal cystine accumulation, progressive kidney disease, and multiple extrarenal complications (ERCs). Cysteamine postpones the onset of end‐stage kidney disease (ESKD) and reduces the incidence of ERCs; however, cysteamine is generally initiated upon establishment of the renal Fanconi syndrome (FS) and partial loss of kidney function, whereas data on long‐term effects of cysteamine administered from neonatal age are lacking. An international multicenter retrospective cohort study of siblings with INC was set up to investigate the outcome in relation to age at initiation of cysteamine versus CTNS genotype, with attention to patients treated with cysteamine from neonatal age. None of the siblings treated from neonatal age (n = 9; age 10 ± 6 years) had reached ESKD, while 22% of their index counterparts (n = 9; age 14 ± 5 years) had commenced renal replacement therapy. Siblings treated with cysteamine from the onset of symptoms at a younger age compared with their index counterparts, reached ESKD at a significant older age (13 ± 3 vs. 10 ± 3 years, p = 0.002). In contrast, no significant difference in ERCs was observed between sibling and index patients, independently from the age at initiation of cysteamine. The CTNS genotype had no impact on the overall outcome in this cohort. In INC, presymptomatic treatment with cysteamine results in a better renal outcome in comparison to treatment initiated from the onset of symptoms. This justifies including cystinosis into newborn screening programs.SynopsisIn infantile nephropathic cystinosis, presymptomatic treatment with cysteamine improves the renal outcome which justifies the inclusion of cystinosis into newborn screening programs.
Animal models of compression spinal cord injury
Authors: Ridlen Reggie , McGrath Kristine , Gorrie Catherine A. 
Published: September 2022

AbstractCompression spinal cord injuries are a common cause of morbidity in people who experience a spinal cord injury (SCI). Either as a by‐product of a traumatic injury or due to nontraumatic conditions such as cervical myelitis, compression injuries are growing in prevalence clinically and many attempts of animal replication have been described within the literature. These models, however, often focus on the traumatic side of injury or mimic short‐term injuries that are not representative of the majority of compression SCI. Of this, nontraumatic spinal cord injuries are severely understudied and have an increased prevalence in elderly populations, adults, and children. Therefore, there is a need to critically evaluate the current animal models of compression SCI and their suitability as a method for clinically relevant data that can help reduce morbidity and mortality of SCI. In this review, we reviewed the established and emerging methods of animal models of compression SCI. These models are the clip, balloon, solid spacer, expanding polymer, remote, weight drop, calibrated forceps, screw, and strap methods. These methods showed that there is a large reliance on the use of laminectomy to induce injury. Furthermore, the age range of many studies does not reflect the elderly and young populations that commonly suffer from compression injuries. It is therefore important to have techniques and methods that are able to minimize secondary effects of the surgeries, and are representative of the clinical cases seen so that treatments and interventions can be developed that are specific.
Summertime precipitation extremes and the influence of atmospheric flows on the western slopes of the southern Andes of Perú
Authors: Villalobos‐Puma Elver , Flores‐Rojas Jose Luis , Martinez‐Castro Daniel , Morales Annareli , Lavado‐Casimiro Waldo , Mosquera‐Vásquez Kobi , Silva Yamina 
Published: September 2022

AbstractAlthough climatologically dry, the western slopes of the southern Andes of Peru (WSA) can experience precipitation extremes (PEs) during the summer (December–February) resulting in great economic and human losses. Generally, WSA has a positive upslope gradient in precipitation, meaning more rain falls at higher elevations, but observations have shown this gradient can become negative with higher rainfall near the coastal cities. In this study we analyse 2000–2019 regional atmospheric patterns associated with different upslope precipitation gradients and PEs in WSA using principal component analysis methods and surface station observations. Results show important changes in the atmospheric circulation patterns during the occurrence of PE events. A prevailing pattern of negative southerly wind anomalies and regional warming of the southeastern Pacific Ocean leads to significant increases in moisture along the coast of WSA. Eastern moisture flows associated with the presence of the Bolivian High are observed at upper levels of the atmosphere and transport water vapour from the Amazon to the western side of the Andes. Additionally, there is a blocking effect aloft in response to an intense gradient of geopotential height that attenuates the easterly circulations. These large‐scale mechanisms act to concentrate high precipitable water amounts and high levels of convective available potential energy in the troposphere which favours the vertical velocities essential to trigger PEs. These results increase our knowledge of the large‐scale characteristics of PEs to help with forecasting these impactful events and protecting the more than 1.8 million people living in WSA.