bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical effect of home enteral tube feeding supplementation on nutritional status after esophagectomy with retrosternal gastric tube reconstruction
Authors: Takebayashi Katsushi , Kaida Sachiko , Yamaguchi Tsuyoshi , Otake Reiko , Miyake Toru , Kojima Masatsugu , Iida Hiroya , Maehira Hiromitsu , Mori Haruki , Bamba Shigeki , Shimizu Tomoharu , Sasaki Masaya , Tani Masaji 
Published: August 2022

SummaryBody weight loss and poor nutritional status are frequently observed after esophageal cancer surgery. The aim of this study was to pilot an investigation on the impact of home enteral tube feeding supplementation (HES) for up to 3 months after esophageal cancer surgery. We retrospectively reviewed consecutive 67 esophageal cancer patients who underwent esophagectomy with gastric tube reconstruction. We started HES from April 2017. The patients were divided into 2 groups. Among 67 patients, 40 patients underwent HES between April 2017 and November 2020 (HES group). Other 27 patients who underwent esophagectomy between January 2012 and March 2017 were not administered HES (C group). Thereafter, multiple factors concerning patient nutritional status at long-term follow-up were evaluated. The baseline characteristics were balanced between the two groups. There were no significant differences in nutritional status scores before esophagectomy. The percentage weight loss was less in the HES group compared with the C group both at 3 months and 1 year after surgery: 7.3% (−7.6 to 15.2), 7.7% (−4 to 13.9) in the HES group and 10.6% (−3.6 to 29.1), 10.8% (−5.8 to 20.0) in C group (P &lt; 0.05, P &lt; 0.05). In the patients with anastomotic stenosis, the percentage weight loss was less in the HES group compared with the C group: 7.2% (2.0–14.9) and 14.6% (6.2–29.1), P &lt; 0.05. HES may improve early weight loss in postesophagectomy patients.
Coping, symptoms, and insomnia among people with heart failure during the COVID-19 pandemic
Authors: O’Connell Meghan , Jeon Sangchoon , Conley Samantha , Linsky Sarah , Redeker Nancy S 
Published: August 2022

AbstractAimsIncreases in stress, symptoms of anxiety and depression, and sleep problems have been reported during the Covid-19 pandemic, and people with chronic medical conditions such as heart failure (HF) are especially vulnerable. The purpose of this study was to examine the extent to which sleep characteristics, sleep-related cognitions, anxiety, depression, perceived stress, and changes in these phenomena over time predict ways of coping with pandemic-related stress among participants in the HeartSleep study, a randomized controlled trial of the effects of cognitive behavioural therapy for insomnia (CBT-I) in people with HF.Methods and resultsParticipants completed questionnaires to elicit sleep characteristics, daytime symptoms, mood and stress at baseline, 6 months after the intervention and during the Covid-19 pandemic. We added measures of coping during the pandemic (June–August 2020). The sample included 112 participants (M age = 63 ± 12.9 years; 47% women; 13% Black; 68% NY Heart Class II or III). Participants (43%) reported pandemic-related stressors and most often used secondary control coping. Insomnia severity, anxiety, depression, perceived stress, and sleep-related cognitions predicted secondary control coping (positive thinking, cognitive restructuring, acceptance, distraction), involuntary engagement (physiological arousal, rumination), and involuntary disengagement (emotional numbing).ConclusionsInsomnia and mood disturbance are important determinants of coping and responses to stress. Improving sleep and symptoms among people with HF may improve coping during stressful events, and CBT-I may have protective effects.RegistrationClinicalTrials.gov: NCT 02660385.
Increased Social Support Reduces the Incidence of Motoric Cognitive Risk Syndrome
Authors: Felix Nicole , Ayers Emmeline , Verghese Joe , Blumen Helena M 
Published: August 2022

Abstract

Background and Objectives
The motoric cognitive risk syndrome (MCR) is a predementia syndrome characterized by slow gait and cognitive complaint. The relationship between MCR and social support—a potentially modifiable risk factor of dementia—is currently unknown. The current study aimed to determine whether MCR incidence varies as a function of social support in aging.

Research Design and Methods
We examined MCR incidence in 506 community-dwelling older adults (M Age 76.59; 57.3% female) without MCR or dementia at baseline. We quantified perceived levels of social support with the Medical Outcomes Study Social Support Survey, incorporating four different categories of support: (a) emotional/informational support, (b) tangible support, (c) affectionate support, and (d) positive social interactions. We used Cox regression analyses, adjusted for age, sex, race/ethnicity, education, marital status, comorbidities, and global cognition, to estimate hazard ratios (aHR) with 95% confidence intervals (CIs).

Results
Over a median follow-up time of 2.5 years (range = 1–7 years), 38 participants (9.8%) developed MCR. Increased tangible support decreased the risk of MCR by 30% (aHR: 0.70, 95% CI: 0.53–0.92, p = .011). Increased overall social support decreased the risk of MCR by 33% (aHR: 0.67, 95% CI: 0.46–0.98, p = .038). Other subcategories of social support were not associated with a decreased risk of MCR (p &gt; .05).

Discussion and Implications
Higher levels of tangible social support, as well as overall social support, were associated with reduced risk for MCR in older adults. Increasing social support may be a promising avenue of intervention for reducing the risk of MCR, dementia, and other forms of cognitive decline.
Can’t stop thinking aboutStar WarsandThe Office: antecedents of retrospective imaginative involvement
Authors: Ulusoy Ezgi , Sethi Neha , Baldwin Joshua , Grady Sara M , Ewoldsen David R 
Published: August 2022

AbstractRetrospective imaginative involvement (RII) is a concept that encapsulates how audiences reflect back on a narrative’s characters and events after the story has ended. The current study aims to explicate the antecedents of RII in order to provide initial steps toward creating a theory of RII. Through two studies, we tested the role of familiarity, traits (e.g., curiosity), entertainment experiences broadly (e.g., parasocial relationships), and content- or exposure-specific experiences (e.g., boundary expansion). Results suggest that RII plays an important role in self-regulation through repeated asynchronous engagement with specific narratives. This demonstrates a further mechanism by which narratives impact our lives even after the exposure. Further results and implications are discussed.
Constitutional review of negotiated international investment agreements: Strengths and shortcomings of the Colombian Constitutional Court’s approach
Authors: Ochoa-Sánchez Juan Carlos 
Published: August 2022

Abstract
Increasingly, international investment agreements (IIAs) and investor–state dispute settlement (ISDS) mechanisms relate to, and at times conflict with, constitutional rights, principles, and rules. Because of this interrelationship, since 2017, constitutional courts in several regions of the world have had to examine constitutional charges brought against IIAs when conducting their ex ante constitutional review of negotiated IIAs. In order to fill significant gaps in the current literature on the subject, this article conducts an in-depth analysis of the judgment of the Colombian Constitutional Court (CCC) which examined the constitutionality of the negotiated bilateral investment treaty (BIT) between Colombia and France (“the investment Agreement”). This article demonstrates that, while the CCC’s judgment has several positive aspects, it also has some significant shortcomings. The Court set the basis for a stricter ex ante constitutional review of IIAs, specifically the rationales, methods, and grounds for review that constitutional courts can use to conduct such a review. The Court also shed light on the methodology to interpret IIAs, the conditional constitutionality approach, and orders that constitutional courts can adopt in this type of review. However, this article demonstrates that the Court’s review over many aspects of the three sets of elements that it covered—i.e. the investment Agreement as a whole and the Agreement’s provisions on standards of treatment and ISDS, was not thorough or it applied a looser test than its reasonableness test. This research also shows that the Court did not engage in review of the investment Agreement concerning its compatibility with economic, social, and cultural rights.
Acute and Chronic Toxicity of Neem Oil to the Endoparasitoid Palmistichus elaeisis (Hymenoptera: Eulophidae)
Authors: Vieira Caldeira Zaira , Alvarenga Soares Marcus , Von dos Santos Veloso Ronnie , Souza Silva Cleriston , Souza Pereira Costa Elizangela , Martins dos Santos Marinalva , Moreira da Silva Isabel , Meloni Silva Wiane , Cola Zanuncio José 
Published: August 2022

Abstract
Palmistichus elaeisis Delvare and LaSalle 1993 (Hymenoptera: Eulophidae) and neem oil are two control alternatives for the integrated management of defoliating lepidopterans. The aim of this study was to evaluate the acute and chronic toxicity of neem oil compared to the synthetic insecticide deltamethrin, on the endoparasitoid P. elaeisis, in generations F0, F1, F2, and F3. Females of P. elaeisis were exposed to neem solutions at concentrations of 0, 1.87, 3.75, 7.50, 15.00, 30.00, and 60.00 mg ml−1, to determine the dose-response relationship and estimate the neem LC50. The sublethal effects on the parasitoid P. elaeisis in generations F0 to F3 were evaluated with these same concentrations of neem and 0.033 mg ml−1 of deltamethrin. The neem LC50 was estimated at 3.92 mg ml−1. The LC50 for P. elaeisis is 3.83 times lower than that recommended by the neem manufacturer for pest control, demonstrating high acute toxicity to this natural enemy. The chronic toxicity of both the commercial dose and those below it to P. elaeisis caused low sublethal effects. The correct concentration of neem oil in pest control is important, and its use should be performed with caution in integrated pest management programs using the endoparasitoid P. elaeisis to avoid causing interference between the two pest control techniques.
Equivalence between Varieties of Łukasiewicz–Moisil Algebras and Rings
Authors: López Martinolich Blanca Fernanda , Vannicola María del Carmen 
Published: August 2022

Abstract
The Post, axled and Łukasiewicz–Moisil algebras are important lattices studied in algebraic logic. In this paper, we investigate a useful interpretation between these algebras and some rings. We give a term equivalence between Post algebras of order $p$ and $p$-rings, $p$ prime and lift this result to the axled Łukasiewicz–Moisil algebra $L \cong B_s \times P$ and the ring $\prod ^s F_2 \times \prod ^l F_p$, where $B_s$ is a Boolean algebra of order $2^s$, $P$ a $p$-valued Post algebra of order $p^l$ and $F_p$ is the prime field of order $p$.
Regional differences in human papillomavirus type 52 prevalence among Japanese women with cervical intraepithelial neoplasia
Authors: Kukimoto Iwao , Onuki Mamiko , Yamamoto Kasumi , Yahata Hideaki , Aoki Yoichi , Yokota Harushige , Konnai Katsuyuki , Nio Ai , Takehara Kazuhiro , Kamiura Shoji , Tsuda Naotake , Takei Yuji , Shimada Muneaki , Nakai Hidekatsu , Yoshida Hiroyuki , Motohara Takeshi , Yamazaki Hiroyuki , Nakamura Keiichiro , Okunomiya Asuka , Tasaka Nobutaka , Ishikawa Mitsuya , Hirashima Yasuyuki , Shimoji Yuko , Mori Mayuyo , Iwata Takashi , Takahashi Fumiaki , Yoshikawa Hiroyuki , Yaegashi Nobuo , Matsumoto Koji ,   MINT Study Group
Published: August 2022

Abstract
Although geographical differences in the distribution of human papillomavirus genotypes have been observed worldwide, no studies have reported on national differences in the prevalence of human papillomavirus types in Japan. Here, we report a cross-sectional study to explore regional differences in the prevalence of human papillomavirus types among Japanese women with cervical intraepithelial neoplasia or invasive cervical cancer. Using human papillomavirus genotyping data from the nationwide prospective study on human papillomavirus vaccine effectiveness, we compared the frequency of detection of 15 high-risk and two low-risk human papillomavirus types in each disease category between the women who visited hospitals located in eastern Japan and those who visited hospitals located in western Japan. The risk of cervical intraepithelial neoplasia progression was assessed by calculating a prevalence ratio of each human papillomavirus type for cervical intraepithelial neoplasia grade 2/3 versus grade 1. Among the human papillomavirus types studied, human papillomavirus 52 was detected significantly more frequently in western hospitals than in eastern hospitals in cervical intraepithelial neoplasia grade 1 patients, but was less frequent in cervical intraepithelial neoplasia grade 2/3. The prevalence of particular human papillomavirus types was not significantly different between patients in hospitals in eastern Japan and those in hospitals in western Japan for invasive cervical cancer. In both eastern and western hospitals, a higher risk of cervical intraepithelial neoplasia progression was observed in patients infected with human papillomavirus 16, 31 or 58. In contrast, there was a significantly higher prevalence of human papillomavirus 52 infection in women with cervical intraepithelial neoplasia grade 2/3 than in those with cervical intraepithelial neoplasia grade 1 in eastern hospitals (prevalence ratio, 1.93; 95% confidence interval, 1.48–2.58), but not in western hospitals (prevalence ratio, 1.03; 95% confidence interval, 0.83–1.30). Regional differences of human papillomavirus 52 prevalence in cervical intraepithelial neoplasia lesions may exist and emphasize the importance of continuous monitoring of human papillomavirus type prevalence throughout the country in order to accurately assess the efficacy of human papillomavirus vaccines.
Estimating international migration flows for the Asia-Pacific region: Application of a generation–distribution model
Authors: Raymer James , Guan Qing , Shen Tianyu , Wiśniowski Arkadiusz , Pietsch Juliet 
Published: August 2022

AbstractFlows of international migration are needed in the Asia-Pacific region to understand the patterns and corresponding effects on demographic, social, and economic change across sending and receiving countries. A major challenge to this understanding is that nearly all of the countries in this region do not gather or produce statistics on flows of international migration. The only information that are widely available represent immigrant population stocks measured at specific points in time—but these represent poor proxies for annual movements. In this paper, we present a methodology for indirectly estimating annual flows of international migration amongst 53 populations in the Asia-Pacific region and four macro world regions from 2000 to 2019 using a generation–distribution framework. The estimates suggest that 27–31 million persons from the Asia-Pacific region have changed their countries of usual residence during each year in the study. Southern Asia is estimated to have had the largest inflows and outflows, whilst intra-regional migration and return migration were highest in Eastern, Southern, and South-Eastern Asia. India, China, and Indonesia were estimated to have had the largest emigration flows and net migration losses. As a first attempt to estimate international migration flows in the Asia-Pacific region, this paper provides a basis for understanding the dynamics and complexity of the large-scale migration occurring in the region.
TheS. cerevisiaem6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts
Authors: Scutenaire Jérémy , Plassard Damien , Matelot Mélody , Villa Tommaso , Zumsteg Julie , Libri Domenico , Séraphin Bertrand 
Published: August 2022

AbstractN6-Methyladenosine (m6A), one of the most abundant internal modification of eukaryotic mRNAs, participates in the post-transcriptional control of gene expression through recruitment of specific m6A readers. In Saccharomyces cerevisiae, the m6A methyltransferase Ime4 is expressed only during meiosis and its deletion impairs this process. To elucidate how m6A control gene expression, we investigated the function of the budding yeast m6A reader Pho92. We show that Pho92 is an early meiotic factor that promotes timely meiotic progression. High-throughput RNA sequencing and mapping of Pho92-binding sites following UV-crosslinking reveal that Pho92 is recruited to specific mRNAs in an m6A-dependent manner during the meiotic prophase, preceding their down-regulation. Strikingly, point mutations altering m6A sites in mRNAs targeted by Pho92 are sufficient to delay their down-regulation and, in one case, to slow down meiotic progression. Altogether, our results indicate that Pho92 facilitate the meiotic progression by accelerating the down-regulation of timely-regulated mRNAs during meiotic recombination.
A Randomized Clinical Trial of Regdanvimab in High-Risk Patients With Mild-to-Moderate Coronavirus Disease 2019
Authors: Kim Jin Yong , Săndulescu Oana , Preotescu Liliana-Lucia , Rivera-Martínez Norma E , Dobryanska Marta , Birlutiu Victoria , Miftode Egidia G , Gaibu Natalia , Caliman-Sturdza Olga , Florescu Simin-Aysel , Shi Hye Jin , Streinu-Cercel Anca , Streinu-Cercel Adrian , Lee Sang Joon , Kim Sung Hyun , Chang Ilsung , Bae Yun Ju , Suh Jee Hye , Chung Da Rae , Kim Sun Jung , Kim Mi Rim , Lee Seul Gi , Park Gahee , Eom Joong Sik 
Published: August 2022

Abstract

Background
We evaluated clinical effectiveness of regdanvimab (CT-P59), a severe acute respiratory syndrome coronavirus 2 neutralizing monoclonal antibody, in reducing disease progression and clinical recovery time in patients with mild-to-moderate coronavirus disease 2019 (COVID-19), primarily Alpha variant.

Methods
This was phase 3 of a phase 2/3 parallel-group, double-blind, randomized clinical trial. Outpatients with mild-to-moderate COVID-19 were randomized to single-dose regdanvimab 40 mg/kg (n = 656) or placebo (n = 659), alongside standard of care. The primary endpoint was COVID-19 disease progression up to day 28 among “high-risk” patients. Key secondary endpoints were disease progression (all randomized patients) and time to recovery (high-risk and all randomized patients).

Results
Of 1315 randomized patients, 880 were high risk; the majority were infected with Alpha variant. The proportion with disease progression was lower (14/446, 3.1% [95% confidence interval {CI}, 1.9%–5.2%] vs 48/434, 11.1% [95% CI, 8.4%–14.4%]; P &lt; .001) and time to recovery was shorter (median, 9.27 days [95% CI, 8.27–11.05 days] vs not reached [95% CI, 12.35–not calculable]; P &lt; .001) with regdanvimab than placebo. Consistent improvements were seen in all randomized and non-high-risk patients who received regdanvimab. Viral load reductions were more rapid with regdanvimab. Infusion-related reactions occurred in 11 patients (4/652 [0.6%] regdanvimab, 7/650 [1.1%] placebo). Treatment-emergent serious adverse events were reported in 5 of (4/652 [0.6%] regdanvimab and 1/650 [0.2%] placebo).

Conclusions
Regdanvimab was an effective treatment for patients with mild-to-moderate COVID-19, significantly reducing disease progression and clinical recovery time without notable safety concerns prior to the emergence of the Omicron variant.

Clinical Trials Registration
NCT04602000; 2020-003369-20 (EudraCT).
MCU proteins dominate in vivo mitochondrial Ca2+ uptake in Arabidopsis roots
Authors: Ruberti Cristina , Feitosa-Araujo Elias , Xu Zhaolong , Wagner Stephan , Grenzi Matteo , Darwish Essam , Lichtenauer Sophie , Fuchs Philippe , Parmagnani Ambra Selene , Balcerowicz Daria , Schoenaers Sébastjen , de la Torre Carolina , Mekkaoui Khansa , Nunes-Nesi Adriano , Wirtz Markus , Vissenberg Kris , Van Aken Olivier , Hause Bettina , Costa Alex , Schwarzländer Markus 
Published: August 2022

Abstract
Ca2+ signaling is central to plant development and acclimation. While Ca2+-responsive proteins have been investigated intensely in plants, only a few Ca2+-permeable channels have been identified, and our understanding of how intracellular Ca2+ fluxes is facilitated remains limited. Arabidopsis thaliana homologs of the mammalian channel-forming mitochondrial calcium uniporter (MCU) protein showed Ca2+ transport activity in vitro. Yet, the evolutionary complexity of MCU proteins, as well as reports about alternative systems and unperturbed mitochondrial Ca2+ uptake in knockout lines of MCU genes, leave critical questions about the in vivo functions of the MCU protein family in plants unanswered. Here, we demonstrate that MCU proteins mediate mitochondrial Ca2+ transport in planta and that this mechanism is the major route for fast Ca2+ uptake. Guided by the subcellular localization, expression, and conservation of MCU proteins, we generated an mcu triple knockout line. Using Ca2+ imaging in living root tips and the stimulation of Ca2+ transients of different amplitudes, we demonstrated that mitochondrial Ca2+ uptake became limiting in the triple mutant. The drastic cell physiological phenotype of impaired subcellular Ca2+ transport coincided with deregulated jasmonic acid-related signaling and thigmomorphogenesis. Our findings establish MCUs as a major mitochondrial Ca2+ entry route in planta and link mitochondrial Ca2+ transport with phytohormone signaling.
Tidal Volume and Positive End-expiratory Pressure and Postoperative Hypoxemia during General Anesthesia: A Single-center Multiple Crossover Factorial Cluster Trial
Authors: Turan Alparslan , Esa Wael Ali Sakr , Rivas Eva , Wang Jiayi , Bakal Omer , Stamper Samantha , Farag Ehab , Maheswari Kamal , Mao Guangmei , Ruetzler Kurt , Sessler Daniel I. ,   for the Ventilation-PEEP Trial Group
Published: August 2022

Background
Intraoperative mechanical ventilation is a major component of general anesthesia. The extent to which various intraoperative tidal volumes and positive end-expiratory pressures (PEEP) effect on postoperative hypoxia and lung injury remains unclear. We hypothesized that adults having orthopedic surgery, ventilation using different tidal volumes and PEEP levels affect the oxygenation within first hour in the postoperative care unit.

Methods
We conducted a two-by-two factorial crossover cluster trial at the Cleveland Clinic Main Campus. We enrolled patients having orthopedic surgery with general anesthesia who were assigned to factorial clusters with tidal volumes of 6 or 10 ml/kg of predicted body weight and to PEEP of 5 or 8 cm H2O in 1-week clusters. The primary outcome was the effect of tidal volume or PEEP on time-weighted average peripheral oxygen saturation measured by pulse oximetry divided by the fraction of inspired oxygen (Spo
2/Fio
2 ratio) during the initial postoperative hour.

Results
We enrolled 2,860 patients who had general anesthesia for orthopedic surgery from September 2018 through October 2020. The interaction between tidal volume and PEEP was not significant (P = 0.565). The mean ± SD time-weighted average of Spo
2/Fio
2 ratio was 353 ± 47 and not different in patients assigned to high and low tidal volume (estimated effect, 3.5%; 97.5% CI, –0.4% to 7.3%; P = 0.042), for those assigned to high and low PEEP (estimated effect, –0.2%; 97.5% CI, –4.0% to 3.6%; P = 0.906). We did not find significant difference in ward Spo
2/Fio
2 ratio, pulmonary complications, and duration of hospitalization among patients assigned to various tidal volumes and PEEP levels.

Conclusions
Among adults having major orthopedic surgery, postoperative oxygenation is similar, with tidal volumes between 6 and 10 ml/kg and PEEP between 5 and 8 cm H2O. Our results suggest that any combination of tidal volumes between 6 and 10 ml/kg and PEEP between 5 versus 8 ml cm H2O can be used safely for orthopedic surgery.

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