bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal flow and heat performance analyses in circular pipe using different twisted tape parameters based on design of experiments
Authors: Al‐Obaidi Ahmed Ramadhan 
Published: June 2022

AbstractIn different energy conservation types, heat transfer improvement is a significant field that is directly connected to systems of economic efficiency. In this analysis, different twisted tape configurations are considered such as the augmentation thermal approach, the impact of various twisted tape parameters on the thermal performance of flow pattern, improvement of heat transfer are numerically conducted. The geometrical configurations used for this investigation include twisted tape thickness, twisted tape width, inward thickness and number of turns. The design of the technique of the experiment is used to investigate the effect of these parameters on hydraulic flow structure and enhancement of heat transfer. The Taguchi method is based on analysis of changes and performs the orthogonal arrays. Besides this, the orthogonal array of L16 is selected for this numerical work. The average percentage error between the experimental and computational fluid dynamics (CFD) outcomes for Nu number and friction factor are noted at about 6.5% and 4.5%. It is observed that the best twisted tape configuration design is obtained by applying CFD methodology compared with the Taguchi method to improve the heat performance using the performance evaluation factor (PEF) was more than 1.2. The maximum value of temperature differences and friction factor was for model 13. Moreover, the thermal performance was good as the values of PEF and the values of PEF are greater than 1.
Comparison of infectious complications after spleen preservation versus splenectomy during laparoscopic distal pancreatectomy for benign or low‐grade malignant pancreatic tumors: A multicenter, propensity score‐matched analysis
Authors: Lee Woohyung , Hwang Dae Wook , Han Ho‐Seong , Han In Woong , Heo Jin Seok , Unno Michiaki , Ishida Masaharu , Tajima Hiroshi , Nishizawa Nobuyuki , Nakata Kohei , Seyama Yasuji , Isikawa Yoshiya , Hwang Ho Kyoung , Jang Jin‐Young , Hong Taeho , Park Joon Seong , Kim Hee Joon , Jeong Chi‐Young , Matsumoto Ippei , Yamaue Hiroki , Kawai Manabu , Ohtsuka Masayuki , Mizuno Shugo , Asakuma Mitsuhiro , Soejima Yuji , Hirashita Teijiro , Sho Masayuki , Takeda Yutaka , Park Jeong‐Ik , Kim Yong Hoon , Kim Hwa Jung , Yamaue Hiroki , Yamamoto Masakazu , Endo Itaru , Nakamura Masafumi , Yoon Yoo‐Seok 
Published: June 2022

AbstractBackgroundPrevious studies have reported contrasting results regarding the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications.MethodsA total of 3787 patients who underwent LDP for benign or low‐grade malignant pancreatic disease in 92 centers across Korea and Japan were included in this retrospective study. Postoperative infectious complications and other complications were compared between LDP with splenectomy (LDPS) and LDP with spleen preservation (LSPDP) by propensity score matching (PSM) analysis.ResultsAfter PSM, the LSPDP group had a lower rate of overall infectious complications (P = .079) and a significantly lower rate of intra‐abdominal abscess (P = .014) compared with the LDPS group. Within the LSPDP group, the vessel preservation subgroup had a significantly higher rate of infectious complications (P = .002) compared with the vessel resection subgroup. Low‐volume centers had a higher rate of intra‐abdominal abscess than high‐volume centers in the LSPDP group (P = .001) and the splenic vessel preservation subgroup (P = .003).ConclusionsSpleen preservation in LDP for benign or borderline malignant pancreatic diseases was advantageous in lowering the risk of infectious complications, specifically intra‐abdominal abscess. However, the risk of intra‐abdominal abscess may differ according to the level of surgeon's experience.
Descriptive social norms and herders' social insurance participation in Mongolia: A survey experiment
Authors: Byambaa Munkhbayar , Yamada Kyohei 
Published: June 2022

AbstractThis paper examines whether descriptive social norms affect one's intention to participate in voluntary social insurance in Mongolia. It reports the results of a survey experiment conducted in September 2020 among herders, whose rate of participation in voluntary social insurance is low and who presumably lack information about others' behaviours with respect to social insurance enrollment. Building upon prior research on descriptive social norms, we hypothesise that herders would be more willing to participate in voluntary social insurance when given information that many others are participating. The respondents were randomly assigned to two groups: one group received information that many others were participating in social insurance, and the other received information that the participation rate was low. We find that those who were given information on the high participation rate expressed a greater willingness to participate in social insurance in the future than the other group.
Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6‐deficient spondylodysplastic Ehlers–Danlos syndrome
Authors: Nikpour Mahnaz , Noborn Fredrik , Nilsson Jonas , Van Damme Tim , Kaye Olivier , Syx Delfien , Malfait Fransiska , Larson Göran 
Published: June 2022

AbstractThe spondylodysplastic type of Ehlers–Danlos syndrome (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate proteoglycans. In this study, we have analyzed the linkage regions of urinary chondroitin sulfate proteoglycans of three siblings, diagnosed with spEDS and carrying biallelic pathogenic variants of the B3GALT6 gene. Proteoglycans were digested with trypsin, glycopeptides enriched on anion‐exchange columns, depolymerized with chondroitinase ABC, and analyzed by nLC‐MS/MS. In urine of the unaffected mother, the dominating glycopeptide of bikunin/protein AMBP appeared as only one dominating (99.9%) peak with the canonical tetrasaccharide linkage region modification. In contrast, the samples of the three affected siblings contained two different glycopeptide peaks, corresponding to the canonical tetrasaccharide and to the non‐canonical trisaccharide linkage region modifications in individual ratios of 61/38, 73/27, and 59/41. We propose that the relative distribution of glycosaminoglycan linkage regions of urinary bikunin glycopeptides may serve as a phenotypic biomarker in a diagnostic test but also as a biomarker to follow the effect of future therapies in affected individuals.
Myelin loss in C9orf72 hexanucleotide expansion carriers
Authors: Sirisi Sònia , Querol‐Vilaseca Marta , Dols‐Icardo Oriol , Pegueroles Jordi , Montal Victor , Muñoz Laia , Torres Soraya , Ferrer‐Raventós Paula , Iulita Maria Florencia , Sánchez‐Aced Érika , Blesa Rafael , Illán‐Gala Ignacio , Molina‐Porcel Laura , Borrego‐Ecija Sergi , Sánchez‐Valle Raquel , Clarimon Jordi , Belbin Olivia , Fortea Juan , Lleó Alberto 
Published: June 2022

AbstractThe most frequent genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the hexanucleotide repeat expansion in C9orf72. An important neuropathological hallmark associated with this mutation is the accumulation of the phosphorylated form of TAR (trans‐activation response element) DNA‐binding protein 43 (pTDP‐43). Glia plays a crucial role in the neurodegeneration observed in C9orf72‐associated disorders. However, less is known about the role of oligodendrocytes (OLs). Here, we applied digital neuropathological methods to compare the expression pattern of glial cells in the frontal cortex (FrCx) of human post‐mortem samples from patients with C9‐FTLD and C9‐FTLD/ALS, sporadic FTLD (sFTLD), and healthy controls (HCs). We also compared MBP levels in CSF from an independent clinical FTD cohort. We observed an increase in GFAP, and Iba1 immunoreactivity in C9 and sFTLD compared to controls in the gray matter (GM) of the FrCx. We observed a decrease in MBP immunoreactivity in the GM and white matter (WM) of the FrCx of C9, compared to HC and sFTLD. There was a negative correlation between MBP and pTDP‐43 in C9 in the WM of the FrCx. We observed an increase in CSF MBP concentrations in C9 and sFTLD compared to HC. In conclusion, the C9 expansion is associated with myelin loss in the frontal cortex. This loss of MBP may be a result of oligodendroglial dysfunction due to the expansion or the presence of pTDP‐43 in OLs. Understanding these biological processes will help to identify specific pathways associated with the C9orf72 expansion.
Modeling and optimization of polyphenol extraction from the petals of Clitorea ternatea using response surface methodology
Authors: Janarny Ganesamoorthy , Ranaweera Kamburawala Kankanamge Don Somathilaka , Gunathilake Katugampalage Don Prasanna Priyantha 
Published: June 2022

AbstractBackgroundClitorea ternatea flowers possess various health benefits owing to their bioactive composition. However, effective extraction of bioactives is important to appropriately utilize these flowers. This work aimed to use response surface methodology, to simultaneously optimize the process parameters to obtain maximum yield of phenolics and anthocyanins along with maximum DPPH radical scavenging activity from C. ternatea flowers.ResultsCentral composite design was employed with four independent variables; solid: liquid ratio (XA), ethanol concentration (XB), temperature (XC), and time (XD) which were found to affect the response variables significantly and fit to the second order polynomial model. The optimum process parameters obtained were XA‐1:50(W/V), XB‐37.21%, XC‐45°C and XD‐50.75 min. The experimental values obtained based on optimum extraction parameters agreed with the predicted values.ConclusionsThe findings suggest the application of optimized parameters to acquire functionally active phenolics and anthocyanins from C. ternatea flowers using ethanol and make use of them in the food and pharmaceutical industry.
A novel limb‐salvage reconstruction strategy with a custom hemipelvic endoprosthesis and preserved femoral head following the resection of periacetabular tumors: A preliminary study
Authors: Xie Xianbiao , Jin Qinglin , Zhao Zhiqiang , Wang Yongqian , Wang Bo , Zou Changye , Yin Junqiang , Huang Gang , Shen Jingnan 
Published: June 2022

AbstractThe treatment of periacetabular malignancy frequently challenges surgeons. To simplify the surgical procedure, we performed a novel reconstruction strategy preserving the femoral head for patients with periacetabular malignancies. We retrospectively reviewed 14 patients who underwent total en bloc resection of a periacetabular tumor and reconstruction of the hip joint with an individualized hemipelvic endoprosthesis and remaining femoral head from July 2015 to January 2019 at our center. Regions of pelvic resection: region II—4 (28.6%), region I + II—5 (35.7%), region II + III—2 (14.3%) and region I + II + III—3 (21.4%). The oncological outcomes were that 13 patients survived without disease and one patient survived with lung metastasis. None of the patients experienced local recurrence (range: 20–62 months; mean: 32 months). The incidence of postoperative complications was 35.7%, including delayed wound healing and deep venous thrombosis. No prosthesis‐related complications occurred until the last follow‐up in this study (range: 20–62 months; mean: 32 months). The mean Musculoskeletal Tumor Society functional outcome score was 23.2. The mean Toronto Extremity Salvage Score of the patients was 75.7 points, with a mean limb discrepancy of 1.51 cm (range: 0.5–3.2 cm). Reconstruction with preservation of the femoral head showed acceptable early functional and oncological outcomes, and it had an acceptable complication rate.
Fixed drug eruption after the Sinopharm COVID‐19 vaccine
Authors: Rekabi Mahsa , Sadati Elham , Mirzaei Jamal , Pourdowlat Guitti , Velayati Ali Akbar , Honarpisheh Parisa 
Published: June 2022

AbstractAfter coronavirus disease 2019 (COVID‐19) became widespread around the world, several vaccines have been developed with variable efficacy and potency and based on different platforms to control the pandemic. One of these vaccines is Sinopharm (BBIBP‐CorV), which is an inactivated virus that was released by Sinopharm's Beijing institute in the summer of 2020. The most commonly reported side effects of the Sinopharm vaccine have included pain at the injection site, muscle pain, headache and fatigue. Dermatological reactions are also reported as less common and were mainly local injection site reactions. Fixed drug eruption (FDE) is a rare and unusual adverse effect and accounts for less than 1% of all severe acute respiratory syndrome coronavirus 2 vaccine‐related cutaneous manifestations. FDE has not been reported following the COVID‐19 inactivated vaccine. Here, we describe a rare case of FDE following the administration of the first shot of the Sinopharm vaccine.
Secukinumab improves the quality‐of‐life of family members and partners of people with psoriasis: Family Dermatology Life Quality Index (FDLQI) results from a randomised open‐label study (SIGNATURE)
Authors: Finlay A. Y. , Barker J. N. , Burden A. D. , Griffiths C. E. M. , Kirby B. , Goodman M. L. , Neill C. , Warren R. B. 
Published: June 2022

AbstractBackgroundThe Family Dermatology Life Quality Index (FDLQI) was developed to meet a need for a dermatology‐specific family member/partner quality‐of‐life (QoL) measure. This paper focuses on the analysis and interpretation of FDLQI data (used as an exploratory outcome) collected in the SIGNATURE study.ObjectivesTo measure the impact of secukinumab therapy for moderate to severe plaque psoriasis on the QoL of family members/partners of patients.MethodsRandomised, open‐label, non‐comparator study in 53 dermatology centres in the UK and Republic of Ireland. Patients received secukinumab 300 or 150 mg subcutaneously weekly for 4 weeks, then 4‐weekly.FDLQI ResultsFamily members of PASI 75 responders and non‐responders showed improved FDLQI compared to baseline, greater for responders. There was a high level of correlation between FDLQI and Dermatology Life Quality Index (DLQI) scores and positive correlations across all mapped FDLQI and DLQI questions, and a close association between the scales at all timepoints. The estimated FDLQI scores were consistently 56% of those obtained for DLQI. There was an improvement for all FDLQI questions at Week 16 with a mean total score change of 8.2. Most family member subjects had an improved score for all FDLQI questions (75%–91%, Week 12, and 77%–91%, Week 16). Family subjects with a corresponding patient visit DLQI score >10 improved for all FDLQI questions at Week 16 (mean total score change of 5.2).ConclusionsSuccessful therapy for severe psoriasis greatly improved QoL of family members/partners. The FDLQI questionnaire responds well and appropriately to major changes in the disease severity of those affected by plaque psoriasis.
Nonviral vector system for cancer immunogene therapy
Authors: Nie Wen , Chen Jing , Wang Bilan , Gao Xiang 
Published: June 2022

AbstractImmunogene therapy has become an effective and significant clinical strategy for cancer therapy. Many immunogene therapies are approved for cancer treatment, and more are undergoing clinical or preclinical trials. Even though most patients benefit greatly from immunogene therapy, the strategies may simply activate the systemic immune response against tumors while also pushing the immune system to supraphysiological levels along with a subsequently increased risk of immune‐related adverse events. Enhancing the response rate to immunogene therapy is key to controlling side effects and improving efficacy. Improved delivery systems can efficiently deliver genes to the desired tumor cells while alleviating adverse reactions and immunogenicity. Thereinto, nonviral vectors improve the permeability, retention, and pharmacokinetic characteristics of drugs, thereby reducing side‐effects and providing broad prospects for enhancing the efficiency of immunotherapy and becoming a leading anticancer candidate. Here, this review highlights the types of common functional nonviral vectors, discusses their advantages and disadvantages, as well as the latest applications in different cancers. Undoubtedly, this review proves that nonviral vectors combined with immunogene therapy are promising treatments for cancers. Nevertheless, further research is needed to solve safety concerns and improve the efficacy of nonviral vectors‐based cancer immunogene therapy for future clinical application.
Genomic evolution of cancer metastasis under therapeutic pressure
Authors: Liu Qiu‐Luo , Li Xi , Chen Hai‐Ning 
Published: June 2022

AbstractIn the era of precision medicine, the selection of cancer treatment relies increasingly on the identification of genomic alterations; however, it is not yet clear how frequently genomic profiling should be performed over the disease course of a patient with metastatic cancer. A large‐scale study investigates the genomic evolution of cancer metastases under therapeutic pressure and finds that the actionable genome has remained relatively stable. The findings support the sufficiency of a single biopsy of cancer metastasis for therapeutic decision‐making.
Tumor immunotherapy: Mechanisms and clinical applications
Authors: Nong Cheng , Guan Pengbo , Li Li , Zhang Huiyuan , Hu Hongbo 
Published: June 2022

AbstractImmunotherapy, which aims to enhance the functions of the host's immune system to eliminate invading pathogens and mutant cells, has been widely used for cancer treatment. Despite the enormous progress in immunotherapy, the efficiency of immunotherapy is urgent to be improved. The tumor microenvironment is composed of multiple types of infiltrating immune cells and stromal cells (such as endothelial cells, fibroblasts, and tumor cells), extracellular matrix, various cytokines, chemokines, growth factors, and metabolites, all of which play crucial roles in tumor progress, metastasis, relapse and the outcome of immunotherapy. Emerging evidence indicates a better understanding of the characteristics of the tumor microenvironment and its associated factors, which could lead to uncovering novel promising immunotherapy approaches. This review will summarize the current knowledge of heterogeneity and function of the immune cells in the tumor microenvironment, the current progress of immunotherapy focusing on immune checkpoint blockade and chimeric antigen T cell therapy, as well as the challenge and limitations of the current immunotherapy strategy. Overall, we aim to provide the conceptions of tumor immune microenvironment and application of immunotherapy, highlighting the potential strategies to improve tumor immunotherapy.
Sonographic reference values of cranial nerve size: A systematic review and meta‐analysis
Authors: Abdelnaby Ramy , Mohamed Khaled Ashraf , ELgenidy Anas , Dardeer Khaled Tarek , Bedewy Mahmoud Mostafa , Sonbol Yousef Tarek , Elmenawi Khaled Abdelmoneim , Elsaeed Eman Mohammed , Kotbe Mostafa Soliman , Shabib Ahmed Samy , Heikal Hamed Amr , Gawish Hazem Maher , Barakat Mahmoud Hesham , Tawfik Eman A. 
Published: June 2022

AbstractIntroduction/AimsUltrasonography of the cranial nerves has recently gained attention for assessment of inflammatory, compressive, or degenerative neuropathies. However, sonographic reference values of cranial nerves have received less attention than those of peripheral nerves. In this systematic review and meta‐analysis we aimed to provide current evidence of sonographic reference values for cranial nerve size.MethodsBy searching Medline (via PubMed), Scopus, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science, we conducted a systematic review and meta‐analysis of studies that reported ultrasound measurements of the facial, spinal accessory, and hypoglossal nerves in healthy adults. We included studies that reported either the sonographic cross‐sectional area (CSA) or the nerve diameter; the included nerves were subgrouped according to the site of nerve measurement.ResultsFourteen studies with a total of 661 participants and 1437 ultrasound nerve measurements met the inclusion criteria. The anatomical sites for each nerve were combined to provide single‐nerve mean measurements. We found an overall mean nerve diameter of 0.80 mm for the facial nerve, 0.63 mm for the spinal accessory nerve, and 1.82 mm2 for hypoglossal nerve CSA.DiscussionThis meta‐analysis provides reference values for the diameter and cross‐sectional area of the facial, spinal accessory, and hypoglossal nerves at different sites, which can be used as guidance in clinical practice to detect pathological changes in cranial nerve size in cranial neuropathies. We recommend further validation in large‐scale studies as well as standardization of the scanning protocols.
Circulating trophoblast numbers as a potential marker for pregnancy complications
Authors: Crovetti Brielle , Maktabi Mohamad Ali , Erfani Hadi , Panchalee Tachjaree , Wang Qun , Vossaert Liesbeth , Van den Veyver Ignatia 
Published: June 2022

AbstractObjectiveTo explore the potential of circulating trophoblasts (TBs) as a non‐invasive tool to assess placental health and predict obstetric complications.MethodsWe retrospectively reviewed maternal characteristics and pregnancy outcomes of 369 women who enrolled in our original cell‐based NIPT (cbNIPT) study. The number of circulating TBs recovered from the maternal blood samples was recorded and expressed as fetal cell concentration (FCC). We evaluated if FCC can be used to predict pregnancy outcomes such as hypertensive disorders of pregnancy (HDP), fetal growth restriction, placental abruption, preterm labor, and pregnancy loss.ResultsReceiver operating characteristic (ROC) analysis was performed to find the best cut off value to classify FCC into a low and high FCC group, and this cut‐off point was calculated as 11.1 cells per 100 ml of blood. The adjusted odds ratio (aOR) for the composite morbidity was significantly increased for the high FCC group at an aOR of 1.6.ConclusionCirculating TB have the potential of predicting obstetrical complications such as HDP. Future studies, with larger sample sizes, should focus on the study of these cells as a biomarker for placental health and a possible screening or diagnostic tool for fetal genetic conditions.