bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mechanism of microRNA-210-5p targeting YAP1 to regulate IL-1β induced endplate cartilage degeneration
Authors: Kong Lei , Gao Dao-Kuan , Xie Yong- Sheng , Ma Xu-Dong , Shang* Xi-Fu 
Published: September 2022

Abstract
MicroRNAs (miRNAs) have emerged as important factors during intervertebral disc degeneration. The cartilage endplate (CEP) is an important site for solute exchange and the import of nutrients for intervertebral disc degeneration. This study was to determine whether miR-210-5p regulates interleukin-1β (IL-1β)-induced expression of YAP1 (Yes-associated protein 1) in rats cartilage endplate (CEP) cells. Rats cartilage endplate cells were stimulated with IL-1β in vitro. In IL-1β stimulated rats CEP cells, YAP1 was down-regulated and miR-210-5p were up-regulated. Functional analysis(Collagen II、Sox-9、MMP-13 ) showed similar results. Up-regulation of miR-210-5p expression by IL-1β was correlated with down-regulation of YAP1 expression in rat CEP cells. Overexpression of YAP1 can alleviated the inhibitory effect of IL-1β on the phenotype of endplate cartilage degeneration cells. MiR-210-5p participates in IL-1β-induced endplate chondrocyte degeneration by regulating YAP1 expression. Silencing of miR-210-5p delayed intervertebral disc degeneration in rats in vivo, the results suggested that miR-210-5p was an important regulator of YAP1 in CEP cells and may regulate the progression of intervertebral disc degeneration.
Drought-stricken U.S. states have more comprehensive water-related hazard planning
Authors: Jedd Theresa , Smith Kelly Helm 
Published: September 2022

Abstract
Despite the devastating impacts of droughts, the United States lacks a national drought plan. This leaves states to address this challenge in water, hazard, and stand-alone drought plans which are designed to reduce drought vulnerability and to prepare government, industry, and society to cope with its impacts. Yet, there is limited empirical research that evaluates the comprehensiveness of these plans in terms of whether they include a range of measures from preparedness and mitigation to triggers for action and response. To fill this gap, we created an evaluation framework using principles from the drought mitigation literature. We evaluated 171 state-level plans with the framework, and simultaneously collected interview data to contextualize the results. The scoring results are then employed in a statistical analysis of whether states with higher physical exposure to drought have higher planning scores. The study finds states that have experienced more frequent and severe drought plan more comprehensively, suggesting that the occurrence of drought may be an intrinsic driver for planning. The results allow for generalizations about what states are doing to mitigate the effects of drought and suggest that worsening drought may be a driver for states to improve their planning.
CT-based body composition parameters predict the loss of response to infliximab in patients with Crohn’s disease
Authors: Wu Hao , Zhang Yini , Shao Xinyi , Wu Xiaoli 
Published: September 2022

Abstract
Purpose: Although the advent of infliximab has improved clinical outcomes for patients with Crohn’s disease, a large proportion of patients still experience loss of response during treatment. The aim of our study was to explore the association between body composition parameters and the loss of response to infliximab in patients with Crohn’s disease(CD).
Methods:118 patients with CD admitted to the First Affiliated Hospital of Wenzhou Medical University and treated with infliximab from June 2015 to December 2021 were retrospectively enrolled. The body composition of patients was analyzed by computed tomography (CT). The primary outcome measure was the loss of response (LOR). Patients were divided into the Remission group and LOR group to analyze the association between body composition parameters and the loss of response to infliximab.
Results The rate of sarcopenia in the LOR group was higher than the Remission group (83.7% vs. 60.0%, P=0.008). Multivariate analysis showed that females had a lower risk of sarcopenia than males (OR=0.30, 95%CI 0.11-0.81, P=0.017); BMI was significantly associated with sarcopenia (OR=0.68, 95%CI 0.56-0.83, P<0.001); L1 CD and L2 CD had a lower risk of sarcopenia than L3 CD (OR=0.29, 95%CI 0.10-0.83, P=0.021; OR=0.25, 95%CI 0.07-0.87, P=0.028).
ConclusionsSarcopenia was identified as a risk factor for developing LOR in infliximab-treated patients.
Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease
Authors: Qiu Jiewen , Peng Guoyou , Tang Yuting , Liu Hanqun , Wei Lijian , Su Yilin , Lin Yuwan , Dai Wei , Zhang Zhiling , Chen Xiang , Ding Liuyan , Guo Wenyuan , Zhu Xiaoqin , Xu Pingyi , Mo Mingshu 
Published: September 2022

Abstract
Background
Parkinson's disease (PD) is a progressive neurodegenerative disease with characteristic pathological abnormalities, including the loss of dopaminergic (DA) neurons, a dopamine-depleted striatum, and microglial activation. Lipid accumulation exhibits a close relationship with these pathologies in PD. Few studies on PD have focused on the lipid profile of cerebrospinal fluid (CSF), which may represent an ideal biomarker for disease diagnosis.
Methods
Here, 6-hydroxydopamine (6-OHDA) was used to construct a rat model of PD, and the lipid profile in CSF obtained from model rats was analyzed using lipidomic approaches.
Results
Establishment of this PD model was confirmed by apomorphine-induced rotation behaviors, loss of DA neurons, depletion of dopamine in the striatum, and microglial activation after 6-OHDA-induced lesion generation. Unsupervised and supervised methods were employed for lipid analysis. A total of 172 lipid species were identified in CSF and subsequently classified into 18 lipid families. Lipid families, including eicosanoids, triglyceride (TG), and free fatty acid (FFA), and 10 lipid species exhibited significantly altered profiles 2 weeks after 6-OHDA administration, and significant changes in eicosanoids, TG, CAR, and 3 lipid species were noted 5 weeks after 6-OHDA administration. During the period of 6-OHDA-induced lesion formation, the lipid families and species showed concentration fluctuations related to the recovery of behavior and nigrostriatal abnormalities. Correlation analysis showed that the levels of eicosanoids, TG families and TG (16:0_20:0_18:1) exhibited positive relationships with apomorphine-induced rotation behaviors and negative relationships with tyrosine hydroxylase (TH) expression in the midbrain.
Conclusions
These results revealed that nonprogressive nigrostriatal degeneration induced by 6-OHDA promotes the expression of an impairment-related lipidomic signature in CSF that may function as a biomarker to aid in PD diagnosis, and the level of eicosanoids, TG families and TG (16:0_20:0_18:1) in CSF may reveal pathological changes in the midbrain of PD patients.
Short-term effects of intravitreal dexamethasone implant on choroidal structure in eyes with refractory diabetic macular edema Contributors
Authors: Bilici Serdar , Serbest Enes , Ugurbas Suat Hayri 
Published: September 2022

Abstract
Purpose
To evaluate choroidal structural changes after intravitreal dexamethasone implant (IDI) in eyes with diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (VEGF) therapy.
Methods
Twenty-three eyes of 14 patients with DME refractory to anti-VEGF therapy were included in this retrospective study. Detailed ophthalmological examinations were recorded and optical coherence tomography (OCT) images were obtained before and 3 months after IDI. Choroidal images were binarized into the luminal area and total choroidal area. Subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) were calculated.
Results
The mean best-corrected visual acuity (BCVA) and central macular thickness (CMT) were improved significantly (from 0.94 to 0.81 LogMAR, p = 0.02, and from 464 to 371 µ, p = 0.01, respectively) after IDI. There were no significant changes in both SCFT and CVI at the end of the follow-up period (from 446.3 to 428.8 µ, p = 0.51 and from 63.1 to 63.7 p = 0.35, respectively).
Conclusion
IDI in eyes with DME refractory to anti-VEGF therapy improves BCVA and CMT but has no significant effect on SCFT and CVI in short term.
Dung Beetle Assembly Affects Nitrous Oxide Emission, Ammonia Volatilizaiton and Nutrient Cycling
Authors: García Carlos C. V. , Dubeux José C. B. , Martini Xavier , Conover Derick , Santos Erick R. S. , Homem Bruno G.C. , Ruiz-Moreno Martin , Silva Izabela A. Gomes , Abreu Daciele S. , Queiroz Luana M. D. , Cleef Flávia O. S. , Santos Mércia V. F. , Fracetto Giselle G. M. 
Published: September 2022

Abstract

This study examined how dung beetle species and assemblage affect nitrous oxide (N2O), ammonia volatilization, and pearl millet [Pennisetum glaucum(L.) R] performance. Seven treatments were applied in pot and they were two controls (only soil and soil + dung without beetles), single species ofOnthophagus taurus(1),Digitonthophagus gazella(2), orPhanaeus vindex[MacLeay] (3); and their assemblages (1 + 2 and 1 + 2 + 3) respectively. After an initial trial assessing gas emissions, pearl millet was planted to assess growth, nitrogen yield (NY), and dung beetle activity after dung application. Dung beetle species increased N2O flow on dung on the 6th day (80 g N2O-N ha− 1day− 1) compared to soil and dung (2.6 g N2O-N ha− 1day− 1). Ammonia emissions varied with the presence of dung beetles (P < 0.05), andD. gazellahad lesser NH3-N on days 1, 6, and 12 with averages of 2061, 1526, and 1048 g ha− 1day− 1, respectively. The soil N content increased with dung + beetle application. Each pot with dung application affected pearl millet herbage accumulation (HA) regardless of dung beetle application, averages ranged from of 5 and 8 g DM pot− 1. A PCA analysis was applied to analyze variation and correlation to each variable, but it indicated a low principal component explanation (less than 80%), not enough to explain the variation in findings. The presence of dung beetles prior to planting improved pearl millet production by enhancing N cycling, although assemblages with the three beetle species enhanced N losses to the environment via denitrification.
Hybrid Arithmetic-Rider Optimization Algorithm as New Intelligent Model for Travelling Salesman Problem
Authors: Krishna Madugula Murali , Majhi Santosh Kumar , Panda Nibedan 
Published: September 2022

Abstract
Travelling Salesman Problem (TSP) is one of the significant NP-hard benchmark problems for performing discrete optimization. In recent times, determining the optimal route mechanism is implemented and ensured as an important mechanism for solving practical applications. In real-time applications, energy-saving, reaching the destination at the assigned time, and identifying the shortest route is very essential. Route determination is researched by different scientists and engineers. Numerous research is done on this problem, and it is still challenging. Therefore, meta-heuristics are involved in this problem as it is inspired by the biological species. This article constitutes the continuation of the work on adapting the TSP using the hybridized algorithm named Arithmetic-ROA (A-ROA). The ultimate aim of the proposed TSP is to reduce the distance travelled by the salesman while focusing on the entire city. For attaining this optimal solution, the novel hybrid A-ROA optimizes the number of the city to be travelled. The results acquired by the new hybrid heuristic are compared with other heuristic algorithms. The computational results confirm that the developed algorithm obtained better results when compared with existing algorithms. The developed optimization algorithm also provides enhanced performance within a realistic amount of computational time.
An improved fuzzy multi-objective nonlinear programming model integrate PSO for water resources optimization allocation under uncertainties
Authors: Ren Chongfeng , Xie Zhishuai , Zhang Yu , Wang Yashi 
Published: September 2022

Abstract
The shortage of water resources has become one of the main factors restricting the development of society, and the impact of the shortage of water resources is particularly obvious in Northwest China in recent years. This paper establishes an inexact fuzzy non-linear multi-objective programming model aiming at the maximum economic benefit and maximum water productivity, which is applied to the actual case of Minqin, Gansu in Northwest China. Improved particle swarm optimization (PSO) is introduced to solve the model, and the optimization scheme of agricultural water resources allocation in the study area is obtained under multiple uncertainties. The results show that the optimization of multi-objective model by IPSO can comprehensively adjust the economic benefits and water productivity. The upper limit of economic benefits can reach 8.84×108 ¥, and the water productivity is 6.29 ¥/m3, which improves the utilization efficiency of water resources and ensures the local economic benefits. The water resources allocation scheme obtained by the multi-objective optimization model can not only provide potential scenarios for local water resources decision-makers, but also provide a reference for the optimal allocation of agricultural water resources in similar areas.
Effects of therapeutic exercise on the motor function of adults with Down syndrome: a systematic review and meta-analysis
Authors: Méndez-Martínez Melanie , Rodríguez-Grande Eliana-Isabel 
Published: September 2022

AbstractBackground Therapeutic exercise exerts positive effects by mitigating or reducing the motor or cognitive changes that people with Down syndrome undergo throughout their life. There are no updated systematic reviews that integrate the evidence available in way that facilitates decision-making for physical rehabilitation teams. This study aimed to assess the effect of different types of physical exercise on the motor function of adults with Down syndrome. Methods We conducted a systematic review and meta-analysis of randomized clinical trials and quasi-experimental studies. The literature search was performed between September 2020 and June 2021 using the PubMed, SCIELO, Epistemonikos, and Lilacs databases. Studies were selected according to pre-determined inclusion and exclusion criteria. The risk-of-bias assessment was performed using the risk-of-bias rating tool. Risk-of-bias assessment and meta-analyses were performed using the RevMan software package. Results Water aerobic exercise significantly increased isometric push-up strength time (mean difference MD = 24.00 [95% CI = 2.66–45.35]; P = 0.03), while combined exercise significantly increased muscle strength both in the upper limbs (MD = 11.93 [95% CI = 4.72–19.14]; P = 0.001) and lower limbs (MD = 18.47 [95% CI = 2.34–34.60]; P = 0.02). Aerobic exercise improved spatiotemporal gait parameters. Aerobic exercise in an aquatic environment and continuous and interval training improved six-minute walk (MD = 43.21 [95% CI = 0.84–85.57]; P = 0.05). The certainty assessment revealed low certainty for all outcomes. Conclusions There was low certainty of evidence for the outcomes proposed in this review. However, therapeutic exercise was shown to be effective in improving muscle strength and gait functionality.
HR-LCMS and Network Pharmacology-based immunity enhancing and pulmonary protection activity of a polyherbal Ayurveda formulation
Authors: Pathak Vijay Kumar , Mahapatra Arun Kumar , Rajagopala S , Gupta Prashant Kumar , Nesari Tanuja Manoj 
Published: September 2022

Abstract
Ayurveda, an integral component of Traditional Indian Medicine systems (AYUSH), advocates preventive and therapeutic approaches to human health care. Ayurveda has a multifaceted contribution to COVID-19 prevention and therapeutics. In addition to vaccination, the AYUSH ministry advocated Bal Ayush Kwatha for the prevention and prophylaxis of COVID-19 among pediatric age. Bal Ayush Kwatha is transformed into jaggery-based syrup for its easy palatability in the pediatric age group and is termed Syrup Bal Ayush Kwatha (SBAK). A search has been made for the computation evidence of SBAK as an immunity enhancer and pulmonary protection. High-Resolution Liquid Chromatography-Mass Spectrometry studies identified 110 botanicals in SBAK. An ADME, in-silico network pharmacology, gene ontology, and KEGG pathway prediction models were constructed for immunity enhancer and pulmonary protection. We find overlapping targets of SBAK botanical out of targets hatched for pulmonary protection and immunity enhancer from the Genecards database. Luteolin, Kaempferol, 4-Hydroxycinnamic acid, and Genistein are the phytoconstituents, and CA2 (Carbonic Anhydrase 2) and ESR2 (Estrogen Receptor 2) are top crucial targets that are responsible for predicted activity through Endocrine resistance and estrogen signaling pathway. Predictive models support the SBAK utility as an immune enhancer and pulmonary protection. Further experimental studies can help in mechanistic understanding of the SBAK. It can also substantiate the wider preventive, prophylactic, and therapeutic utility of Syrup Bal Ayush Kwatha in the pediatric age group.
A Secure Multi-Agent-Based Decision Model Using a Consensus Mechanism for Intelligent Manufacturing Tasks
Authors: Kara M. , Laouid A. , Hammoudeh M. , Karampidis K. , Papadourakis G. , Bounceur A. 
Published: September 2022

Abstract
Accord is an important operation in the mechanism design for multi-agent systems and consequently to applications built for these environments , such as ad hoc networks, virtual organizations, and decision-support tools for smart production systems. Much attention has been given to designing the process for resisting manipulation by strategic voting and decentralized control. The emphasis is on local decision-making based on locally available information and perception of events occurring locally. This manuscript presents a secure decision-support algorithm in a multi-agent system. The proposed consensus-based model serves multiple purposes in production planning and control, supply chain management , and product design and development. In particular, we describe decision-making, the selection of a leader, and the exploitation of limited resources. The importance of the proposal is to ensure robustness in a specific way; in which, decisions are carried out considering that the system is open, which means that the number of agents present is variable at each process. Our model is based on that a group of agents makes different decisions in a task, then the algorithm chooses one of these decisions logically, safe, efficient, and fast and stays away from emotional decisions even in dealing with the decisions of others that affect production.
Efficacy of Gum Arabic as Anti-inflammatory Agent in Sickle Cell Anemia Pediatric Patients : A randomized, double-blind, placebo-controlled Phase III trial
Authors: Abdelmaged DalyaMM , KAddam Lamis AA , Abdelrazig Haydar A , Fadl-Elmula Imad , MohamedSharif Abubaker A , Abdalla Hassan Elhag Hassan , Mohammed Isra Bdraldein Salih , Saeed Amal M. 
Published: September 2022

Abstract
Background: Sickle cell disease is one of the common genetic diseases with an autosomal recessive inheritance. SCD have been acknowledge as an inflammatory condition with several indicators of an inflammatory response involving high level of white blood cell, CRP, cytokines as well as elevated monocytes, neutrophils, platelets and endothelial cells. Oral intake of gum Arabic elevates serum level of short chain fatty acids concentration especially levels of butyrate and propionate. Butyrate is a potent anti-inflammatory, that lowers pro-inflammatory cytokines expression through inhibition of NF-kB. GA works as anti-inflammatory through short chain fatty acids.
Methods: Twenty- one sickle cell anemia patients recruited and giving 30g of gum arabic daily for 12 weeks and levels of CRP, ESR and uric acid were measured before and after full dose of oral GA. Another Twenty- one patient were recruited and this time giving placebo treatment. Same GA investigations were done for placebo group.
Results: Gum Arabic has significant anti-inflammatory effects in SCD patients as CRP level decrease significantly after taking GA.
Conclusion: GA is a potent anti Inflammatory. It reduces Inflammatory markers like CRP in patients with sickle cell disease.
Trial registration: clinicalTrial.gov identifier: NTC04191213. First posted December 9, 219. Retrospective regestriation.
A pilot study to assess the feasibility of a sham anti-inflammatory diet: Can inflammation neutrality and participant blinding be achieved?
Authors: Allison David J. , Agudelo Alexandria Roa , Lawson Arden , Gazzellone Giuseppe , Ditor David S. , Loh Eldon 
Published: September 2022

Abstract
Context: While randomized, double-blind, placebo-controlled trials are the gold standard for investigating the effects of dietary interventions, the complexity of designing such trials has limited their use.
Study Design: Single centre, randomized, double-blind, controlled trial.
Objective: Primary objectives included the assessment of the impact of a sham anti-inflammatory diet on inflammation and participant blinding.
Methods: This dietary advice trial involved participants with spinal cord injury (SCI), randomized to either a sham-diet condition (n=8) or non-dieting control condition (n=8). Participants in the sham-diet group were told they would be randomized to either an anti-inflammatory diet condition, or a sham diet designed to be inflammation-neutral. Participants randomized to the sham-condition completed a diet consultation prior to beginning the diet for a period of 4-weeks. Primary outcomes of interest included the change in inflammation as assessed by plasma concentrations of C-reactive protein (CRP), and participant blinding assessed upon completion of the trial.
Results: All members of the control group and 6 of 8 members of the sham-diet group completed the intervention. Blinding was successful as all 6 members who completed the sham-diet believed they were on the true anti-inflammatory diet. Further, the sham diet was shown to have no significant effect on inflammation over the 4-week intervention period as demonstrated by plasma CRP concentrations.
Conclusion: This pilot study provides preliminary evidence for the utility of a sham-anti-inflammatory diet and could be used to strengthen the design of future dietary interventions utilizing anti-inflammatory diets.