bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort
Authors: Woelfle Tim , Linkohr Birgit , Waterboer Tim , Thorand Barbara , Seissler Jochen , Chadeau-Hyam Marc , Peters Annette 
Published: May 2022

Abstract
Aims/hypothesis
The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology.

Methods
Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (n = 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein–Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA1c.

Results
HSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA1c at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders.

Conclusions/interpretation
The associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies.

Graphical abstract
Effects of seawater pCO2 on the skeletal morphology of massive Porites spp. corals
Authors: Allison Nicola , Ross Phoebe , Brasier Alex , Cieminska Nadia , Lopez Martin Nicolas , Cole Catherine , Hintz Chris , Hintz Ken , Finch Adrian 
Published: May 2022

AbstractOcean acidification alters the dissolved inorganic carbon chemistry of seawater and can reduce the calcification rates of tropical corals. Here we explore the effect of altering seawater pCO2 on the skeletal morphology of 4 genotypes of massive Porites spp. which display widely different calcification rates. Increasing seawater pCO2 causes significant changes in in the skeletal morphology of all Porites spp. studied regardless of whether or not calcification was significantly affected by seawater pCO2. Both the median calyx size and the proportion of skeletal surface occupied by the calices decreased significantly at 750 µatm compared to 400 µatm indicating that polyp size shrinks in this genus in response to ocean acidification. The coenosteum, connecting calices, expands to occupy a larger proportion of the coral surface to compensate for this decrease in calyx area. At high seawater pCO2 the spines deposited at the skeletal surface became more numerous and the trabeculae (vertical skeletal pillars) became significantly thinner in 2 of the 4 genotypes. The effect of high seawater pCO2 is most pronounced in the fastest growing coral and the regular placement of trabeculae and synapticulae is disturbed in this genotype resulting in a skeleton that is more randomly organised. The study demonstrates that ocean acidification decreases the polyp size and fundamentally alters the architecture of the skeleton in this major reef building species from the Indo-Pacific Ocean.
Factors Influencing the Intention to Pursue Surgery among Female Pre‐Medical Students: A Cross‐Sectional Study in Pakistan
Authors: Martins Russell Seth , Fatimi Asad Saulat , Ladak Shamila , Jehanzeb Hamzah , Saleh Raisa , Kumar Gaurav , Kaleem Shamama , Saad Muhammad , Akbar Inaara , Abbas Manzar , Nadeem Sarah , Malik Mahim A. 
Published: May 2022

AbstractBackgroundWhile gender disparities in surgery are documented worldwide, it is unclear to what extent women consider surgery as a career before embarking on their medical school journey. This study aimed to report the percentage of pre‐medical women in Pakistan who intend to eventually specialize in surgery and assess the factors motivating and deterring this decision.MethodsAn online survey was conducted among female pre‐medical (high school) students across Pakistan. Multivariable logistic regression was performed to determine motivating and deterring factors associated with the intention to pursue surgery.ResultsOut of 1219 female high‐school students, 764 (62.7) intended to join medical school. Among these 764, only 9.8% reported an exclusive intent to pursue surgery, while just 20.3% reported considering other specialties in addition to surgery. Significant motivators to pursue surgery exclusively were the intellectual satisfaction of pursuing surgery (adjusted odds ratio: 2.302), having opportunities to travel internationally for work (2.300) and use cutting‐edge technology (2.203), interest in the specialty of surgery (2.031), the social prestige of becoming a surgeon (1.910), and considering one's personality well‐suited to surgery (1.888). Major deterrents included the lack of interest in surgery (adjusted odds ratio: 3.812), surgical education and training being too difficult (2.440) and lengthy (1.404), and the risk of aggressive behavior from patients (2.239).ConclusionEven before entering medical school, most female pre‐medical students have already decided against considering a future surgical career. Deterrents likely stem from women being pressured to conform to deep‐seated societal expectations to dedicate their time and energy to domestic responsibilities.
Intraoperative ultrasonography in laminectomy for degenerative cervical spondylotic myelopathy: a clinical and radiological evaluation
Authors: Biczok Annamaria , Fuetsch Manuel , Siller Sebastian , Patzig Maximilian , Tonn Joerg-Christian , Zausinger Stefan 
Published: May 2022

Abstract
Background
The incidence of cervical myelopathy due to spinal stenosis is constantly growing in an aging population. Especially in multisegmental disease, dorsal laminectomy is the intervention of choice. Intraoperative imaging with ultrasound might provide additional information about extent and sufficiency of spinal cord decompression.

Methods
In this prospective study, the width of the subarachnoid space was systematically measured by intraoperative ultrasound at predefined sites at the cranial and caudal edge of decompression in axial and sagittal reconstruction. These data were compared with corresponding sites on postoperative T2-weighted MRI imaging. In addition, the functional outcome was assessed by modified Japanese Orthopaedic Association (mJOA) score. A historical patient cohort treated without ultrasound-guided laminectomy served as control group.

Results
Altogether, 29 patients were included. According to mJOA score at last follow-up, 7/29 patients reported stable symptoms and 21/29 patients showed a substantial benefit with no or minor residual neurological deficits. One patient suffered from a new C5 palsy. Intraoperative ultrasound-guided posterior decompression provided excellent overview in all cases. Measurement of the width of the subarachnoid space acquired by intraoperative ultrasound and postoperative MRI images showed a very high correlation, especially at the cranial level (p < 0.001, r = 0.880). Bland–Altman analysis showed that most patients were within the 1.96 × SD limits of agreement throughout all measurements. No ultrasound procedure-related complications were observed. Compared to a historical cohort of 27 patients, no significant differences were found regarding functional outcome (p = 0.711).

Conclusion
Intraoperative sonography visualises the surgically achieved restoration of the subarachnoid space in good correlation with postoperative MRI and might serve as a fast, precise and reliable tool for intraoperative imaging in cervical laminectomy. However, we could not demonstrate a clinical benefit with regard to functional outcome.
Low-latency query compilation
Authors: Funke Henning , Mühlig Jan , Teubner Jens 
Published: May 2022

AbstractQuery compilation is a processing technique that achieves very high processing speeds but has the disadvantage of introducing additional compilation latencies. These latencies cause an overhead that is relatively high for short-running and high-complexity queries. In this work, we present Flounder IR and ReSQL, our new approach to query compilation. Instead of using a general purpose intermediate representation (e.g., LLVM IR) during compilation, ReSQL uses Flounder IR, which is specifically designed for database processing. Flounder IR is lightweight and close to machine assembly. This simplifies the translation from IR to machine code, which otherwise is a costly translation step. Despite simple translation, compiled queries still benefit from the high processing speeds of the query compilation technique. We analyze the performance of our approach with micro-benchmarks and with ReSQL, which employs a full translation stack from SQL to machine code. We show reductions in compilation times up to two orders of magnitude over LLVM and show improvements in overall execution time for TPC-H queries up to 5.5
$$\times $$
×
over state-of-the-art systems.
Regional variations in nephrology trainee confidence with clinical skills may relate to the availability of local training opportunities in the UK: results from a national survey
Authors: Selvaskandan Haresh , Baharani Jyoti , Hamer Rizwan 
Published: May 2022

Abstract
Background
The United Kingdom offers a standardised training program for nephrology fellows. However, local training opportunities vary resulting in mismatches between trainee interests and accessible opportunities. This may impact trainee confidence, satisfaction, and future service provision.

Methods
A survey assessing confidence with key procedures and sub-specialities was disseminated. Associations with region of training were probed using Chi square tests, with significance set at p < 0.0008 following a Bonferroni correction. Results were compared to trainee views on available opportunities for development.

Results
139 responses were received (32% response rate, demographics representative of the UK nephrology trainee cohort). Procedural independence varied from 98% for temporary femoral vascular catheters to 5% for peritoneal dialysis catheters (PDIs). Independence with inserting tunnelled vascular catheters varied with region (p < 0.0001). Trainees expressed a desire for formal training in kidney ultrasound scanning and PDIs, corresponding with procedures they had least opportunity to become independent with. Trainees felt least confident managing kidney disease in pregnancy. Suggestions for improving training included protected time for garnering sub-speciality knowledge, developing procedural skills and for experiencing practice in other nephrology units.

Conclusions
A mismatch between trainee interests and professional development opportunities exists, which may threaten trainee autonomy and impact patient care particularly with regards to peritoneal dialysis. Provisions to facilitate trainee directed development need to be made while balancing the rigors of service provision. Such measures could prove critical to promoting trainee well-being and preventing attrition within the nephrology workforce.
Biochar for agronomy, animal farming, anaerobic digestion, composting, water treatment, soil remediation, construction, energy storage, and carbon sequestration: a review
Authors: Osman Ahmed I. , Fawzy Samer , Farghali Mohamed , El-Azazy Marwa , Elgarahy Ahmed M. , Fahim Ramy Amer , Maksoud M. I. A. Abdel , Ajlan Abbas Abdullah , Yousry Mahmoud , Saleem Yasmeen , Rooney David W. 
Published: May 2022

AbstractIn the context of climate change and the circular economy, biochar has recently found many applications in various sectors as a versatile and recycled material. Here, we review application of biochar-based for carbon sink, covering agronomy, animal farming, anaerobic digestion, composting, environmental remediation, construction, and energy storage. The ultimate storage reservoirs for biochar are soils, civil infrastructure, and landfills. Biochar-based fertilisers, which combine traditional fertilisers with biochar as a nutrient carrier, are promising in agronomy. The use of biochar as a feed additive for animals shows benefits in terms of animal growth, gut microbiota, reduced enteric methane production, egg yield, and endo-toxicant mitigation. Biochar enhances anaerobic digestion operations, primarily for biogas generation and upgrading, performance and sustainability, and the mitigation of inhibitory impurities. In composts, biochar controls the release of greenhouse gases and enhances microbial activity. Co-composted biochar improves soil properties and enhances crop productivity. Pristine and engineered biochar can also be employed for water and soil remediation to remove pollutants. In construction, biochar can be added to cement or asphalt, thus conferring structural and functional advantages. Incorporating biochar in biocomposites improves insulation, electromagnetic radiation protection and moisture control. Finally, synthesising biochar-based materials for energy storage applications requires additional functionalisation.
Associations with sub-optimal clinic attendance and reasons for missed appointments among heterosexual women and men living with HIV in London
Authors: Howarth A R , Apea V , Michie S , Morris S , Sachikonye M , Mercer C H , Evans A , Delpech V C , Sabin C , Burns F M 
Published: May 2022

AbstractPoor engagement in HIV care is associated with poorer health outcomes and increased mortality. Our survey examined experiential and circumstantial factors associated with clinic attendance among women (n = 250) and men (n = 106) in London with heterosexually-acquired HIV. While no associations were found for women, among men, sub-optimal attendance was associated with insecure immigration status (25.6% vs. 1.8%), unstable housing (32.6% vs. 10.2%) and reported effect of HIV on daily activities (58.7% vs. 40.0%). Among women and men on ART, it was associated with missing doses of ART (OR = 2.96, 95% CI:1.74–5.02), less belief in the necessity of ART (OR = 0.56, 95% CI:0.35–0.90) and more concern about ART (OR = 3.63, 95% CI:1.45–9.09). Not wanting to think about being HIV positive was the top reason for ever missing clinic appointments. It is important to tackle stigma and the underlying social determinants of health to improve HIV prevention, and the health and well-being of people living with HIV.
Auricular vagus nerve stimulator for closed-loop biofeedback-based operation
Authors: Dabiri Babak , Zeiner Klaus , Nativel Arnaud , Kaniusas Eugenijus 
Published: May 2022

AbstractAuricular vagus nerve stimulation (aVNS) is a novel neuromodulatory therapy used for treatment of various chronic systemic disorders. Currently, aVNS is non-individualized, disregarding the physiological state of the patient and therefore making it difficult to reach optimum therapeutic outcomes. A closed-loop aVNS system is required to avoid over-stimulation and under-stimulation of patients, leading to personalized and thus improved therapy. This can be achieved by continuous monitoring of individual physiological parameters that serve as a basis for the selection of optimal aVNS settings. In this work we developed a novel aVNS hardware for closed-loop application, which utilizes cardiorespiratory sensing using embedded sensors (and/or external sensors), processes and analyzes the acquired data in real-time, and directly governs settings of aVNS. We show in-lab that aVNS stimulation can be arbitrarily synchronized with respiratory and cardiac phases (as derived from respiration belt, electrocardiography and/or photo plethysmography) while mimicking baroreceptor-related afferent input along the vagus nerve projecting into the brain. Our designed system identified > 90% of all respiratory and cardiac cycles and activated stimulation at the target point with a precision of ± 100 ms despite the intrinsic respiratory and heart rate variability reducing the predictability. The developed system offers a solid basis for future clinical research into closed-loop aVNS in favour of personalized therapy.
COVID19 epidemic outbreak: operating rooms scheduling, specialty teams timetabling and emergency patients' assignment using the robust optimization approach
Authors: Arab Momeni Mojtaba , Mostofi Amirhossein , Jain Vipul , Soni Gunjan 
Published: May 2022

AbstractThe health care system is characterized by limited resources, including the physical facilities as well as skilled human resources. Due to the extensive fixed cost of medical facilities and the high specialization required by the medical staff, the problem of resource scarcity in a health care supply chain is much more acute than in other industries. In the pandemic of the Coronavirus, where medical services are the most important services in communities, and protective and preventive guidelines impose new restrictions on the system, the issue of resource allocation will be more complicated and significantly affect the efficiency of health care systems. In this paper, the problem of activating the operating rooms in hospitals, assigning active operating rooms to the COVID-19 and non-COVID-19 patients, assigning specialty teams to the operating rooms and assigning the elective and emergency patients to the specialty teams, and scheduling their operations is studied by considering the new constraints of protective and preventive guidelines of the Coronavirus. To address these issues, a mixed-integer mathematical programming model is proposed. Moreover, to consider the uncertainty in the surgery duration of elective and emergency patients, the stochastic robust optimization approach is utilized. The proposed model is applied for the planning of operating rooms in the cardiovascular department of a hospital in Iran, and the results highlight the role of proper management in supplying sufficient medical resources effectively to respond to patients and scheduled surgical team to overcome the pressure on hospital resources and medical staff results from pandemic conditions.
Unsupervised statistical concept drift detection for behaviour abnormality detection
Authors: Friedrich Björn , Sawabe Taishi , Hein Andreas 
Published: May 2022

AbstractAbnormal behaviour can be an indicator for a medical condition in older adults. Our novel unsupervised statistical concept drift detection approach uses variational autoencoders for estimating the parameters for a statistical hypothesis test for abnormal days. As feature, the Kullback–Leibler divergence of activity probability maps derived from power and motion sensors were used. We showed the general feasibility (min. F1-Score of 91 %) on an artificial dataset of four concept drift types. Then we applied our new method to our real–world dataset collected from the homes of 20 (pre–)frail older adults (avg. age 84.75 y). Our method was able to find abnormal days when a participant suffered from severe medical condition.
Long-term Energy Cost Labelling for Appliances: Evidence from a Randomised Controlled Trial in Ireland
Authors: Denny E. 
Published: May 2022

AbstractGiven the longevity of investments in energy-consuming products (such as household appliances, vehicles, and properties), underinvestment in energy efficiency can have long-lasting negative economic and environmental consequences. Previous research has indicated that underinvestment may be due to imperfect information in relation to the long-term benefits of investing in energy efficiency. This paper presents the results of a cluster randomised controlled trial examining an intervention which aims to overcome this information deficit by providing long-term energy cost information on appliances in an electrical retail chain in Ireland. Two treatments are considered: a label showing 10-year energy cost information based on typical usage for four appliance categories (fridge freezers, dishwashers, washing machines, and tumble dryers); and a second treatment which supplements this label with a QR code where consumers can gain personalised cost estimates based on their expected appliance usage. Results indicate that neither of the treatments resulted in an increase in the average energy efficiency of appliances sold. Also, engagement of customers with the QR code was extremely low. Given that the newly designed EU energy labels incorporate QR codes for personalisation, this low usage suggests that this element of the new labels may be ineffective in increasing the uptake of energy efficiency. Finally, a customer survey suggests that while the treatment increased the stated importance of energy efficiency in decision-making, this did not translate into an increase in efficiency of products purchased, i.e., stated preferences for energy efficiency did not translate into revealed purchasing preferences.
Expendable Lives: Race and Segmented Representation in the Politics of Crime and Criminal Justice in the United States
Authors: Xenakis Sappho , Cheliotis Leonidas K. 
Published: May 2022

AbstractOne of the most enduring debates in the study of the evolution of criminal justice policy in the United States concerns the role of public opinion. Two viewpoints have thus far dominated pertinent scholarship, with one claiming that criminal justice policy has been genuinely responsive to changes in public opinion, and the other suggesting that incumbent administrations have simulated responsiveness to public attitudes toward criminal justice which they strategically molded themselves. Drawing in part on political science literature that has as yet been little used within criminology, this article seeks to advance an alternative viewpoint. We argue that, in the context of American criminal justice policy since the 1970s, political responsiveness to public opinion has been neither genuine nor so much simulated as it has been what political scientists describe as “segmented”—that is, geared toward specific subgroups whose views are privileged for electoral reasons. Our analysis singles out for scrutiny the crucial period between the mid-1980s and mid-1990s and the alignment of criminal justice policymaking during those years with preferences held and promoted by lobby groups with strong financial incentives at the expense of disadvantaged minorities. In so doing, we combine foci and insights that have typically been accorded discrete consideration in prior critical scholarship, which allows us to demonstrate the aggregate effect that different lobbying activities can have on criminal justice, whether directly and by design or indirectly and by default.