bluuebunny/crossref_metadata_2025_split huggingface dataset:
Male breast cancer: a Singapore perspective
Authors: Lim Joshua S. H. , Sim Yirong , Ngeow Joanne , Yuen Jeanette , Tan Veronique K. M. , Tan Benita Kiat Tee , Yong Wei‐Sean , Wong Chow Yin , Lim Sue Zann , Hamzah Julie Liana B. , Tan Si Ying , Wong Fuh Yong , Madhukumar Preetha 
Published: April 2022

AbstractIntroductionMale breast cancer (MBC) is rare, representing <1% of all breast cancers. Treatment recommendations have been extrapolated from trial data of female breast cancer patients. This study aims to report our institutional experience of MBC across a 20 year period, analyse the survival outcome and prognosis of this group against female breast cancer patients treated at the same centre.MethodsClinical, histopathological, treatment and survival data of male and female breast cancer patients treated between Jan 1999 and July 2019 at Singapore General Hospital and National Cancer Centre Singapore were identified and analysed.ResultsFifty‐seven male patients were identified. The median age at diagnosis was 63 years. Majority had invasive ductal carcinoma (86%) and presented at an early disease stage: 70.2% presented as Tis/T1/T2 and 49.1% had no axillary nodal involvement. 84.2% had a simple mastectomy with either a sentinel lymph node biopsy or axillary clearance. The median follow up was 5.69 years for males and 5.83 years for females. The median survival was 11.86 years for males and 16.3 years for females. At 5 years, overall survival (OS) was 69.9% (52.3–82.1%) and disease free survival (DFS) was 62.9% (44.9–76.5%) for males compared with OS 83.8% (83.21–84.39%) and DFS 74.5% (73.91–75.09%) for females.ConclusionMBC remains understudied. Our institutional data indicates that good long term survival in South‐East Asian patients can be achieved with treatment protocols that are similar to female breast cancer. More prospective studies are required.
Ethnicity, gender and seasonal variations all play a role in vitamin D deficiency
Authors: Trollfors Birger 
Published: April 2022

AbstractAim(1) To explore the adherence of recommendations of vitamin D supplementation to children aged 0–4 years. (2) To compare serum levels of vitamin D in children and adolescents aged 0–17 years originating from different parts of the world. (3) To compare levels between boys and girls and (4) To determine seasonal variation.MethodsA review of vitamin D levels in children with parents from different parts of the world was conducted. 2502 children aged 0–17 years were included between 22 January 2004 and 17 May 2021.ResultsFifty‐nine of 363 children aged 0–4 years received the recommended vitamin D supplementation. Children from all parts of the world had lower levels of serum 25(OH)D than Swedish children. Girls from the Indian subcontinent, Middle East and Africa had the lowest levels of s‐25(OH)D. Seasonal variation with higher levels during the summer was seen in children from Sweden, the rest of Europe, Russia and Latin America. Overall prevalence of vitamin D deficiency (≤25 nmol/L) was 928/2198 (42%) in children not receiving supplementation. Seven children had clinical rickets.ConclusionAdherence of giving children aged 0–4 years the recommended vitamin D supplementation was very low. Vitamin D deficiency is common in immigrant children of all ages in Sweden.
High levels of screen time were associated with increased probabilities of lagged development in 3‐year‐old children
Authors: Yu Yen‐Ting , Hsieh Ton‐Lin , Lin Gong‐Hong , Lee Shih‐Chieh , Huang Chien‐Yu , Chen Kuan‐Lin 
Published: April 2022

AbstractAimThis study determined whether higher screen time was associated with the development of 3‐year‐old children in Taiwan. It also examined whether differences would be found between television and other screen‐based media in the probability of lagged development.MethodsWe examined 2139 children aged 3 years and their parents. The association between daily screen time was assessed using multiple logistic regression analysis. All the odds ratios (ORs) were calculated using the rates of lagged developmental achievement, with the group who used screens for less than 1 h a day as the reference category. Screen time comprised television and other screen‐based media, such as smartphones, touch screens, computers and laptops.ResultsChildren who used screens for more than 3 h per day had the lowest developmental scores and highest probabilities of lagged development. The children who used other screen‐based media for more than 1 h per day had greater probabilities of lagged developmental achievements (ORs 1.85–4.98, all p < 0.05) than those who watched television for the same amount of time (OR 1.41–2.77, all p < 0.05).ConclusionIncreased screen time was associated with higher probabilities of lagged developmental achievement in multiple development domains in 3‐year‐old children, particularly other screen‐based media.
Concentrations of psychoactive substances in blood samples from non‐fatal and fatal opioid overdoses
Authors: Edvardsen Hilde Marie Erøy , Aamodt Carl , Bogstrand Stig Tore , Krajci Peter , Vindenes Vigdis , Rognli Eline Borger 
Published: April 2022

AimThe primary aim was to compare concentrations of psychoactive substances in blood in non‐fatal and fatal opioid overdoses. The secondary aim was to assess the concentration levels of naloxone in blood in non‐fatal overdoses and the association between naloxone findings and concomitantly detected drugs.Method DesignCase‐control study.SettingNorway. Fatal overdoses from 2017 and non‐fatal overdoses from February 2018 to September 2019.CasesThirty‐one non‐fatal and 160 fatal opioid overdose cases. Data from the non‐fatal overdoses were collected from hospital records and blood samples, and data from the fatal overdoses were collected from autopsy reports. Concentrations of psychoactive substances (including ethanol) in blood samples were collected at the time of hospital admission for the non‐fatal overdoses and during autopsy for the fatal overdoses.ResultsThe median number of different substances detected was four for fatal and five for non‐fatal overdoses. The fatal overdoses had higher pooled concentrations of opioids (188 vs 57.2 ng/mL, P < .001), benzodiazepines (5467 vs 2051 ng/mL, P = .005) and amphetamines (581 vs 121 ng/mL, P < .001) than the non‐fatal overdoses. A linear relationship between naloxone and concomitant pooled opioid concentrations was found (95% confidence interval = 0.002‐0.135, P < .05).ConclusionThe total load of drug concentrations was associated with the fatal outcome of an overdose, while the number of drugs used, to a lesser extent, differentiated between those who survived and those who died from an overdose. Higher opioid concentrations were associated with treatment with higher naloxone doses.
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice
Authors: Xu Lili , Gao Yaran , Hu Ming , Dong Yanhong , Xu Jing , Zhang Jiawei , Lv Peiyuan 
Published: April 2022

AbstractStroke is the leading cause of disability and death. When blood flow is restored after prolonged ischemia and hypoxia, it leads to excessive production of reactive oxygen species (ROS), increased local inflammation, and apoptosis, which are the cause of most cerebral ischemia reperfusion injury (CIRI), leading to secondary brain tissue damage. Edaravone dexborneol is a novel neuroprotective agent consisting of edaravone and borneol. Studies have shown that it has synergistic antioxidant and anti‐inflammatory effects. However, whether Edaravone dexborneol stimulates the Nrf2/HO‐1 pathway to regulate NADPH oxidase 2 (NOX2) remains unclear. In this study, wild‐type (WT) mice and Nrf2 knockout (KO) mice were used to investigate the antioxidant, anti‐inflammatory, and anti‐apoptotic effects of Edaravone dexborneol on CIRI and its mechanism. The cognitive function of mice was evaluated with the Morris water maze (MWM), test and the cell structures of hippocampus were observed by hematoxylin and eosin (H&E) staining. Nrf2, HO‐1, and NOX2 proteins and apoptosis‐related proteins Bcl‐2, Bax, and Caspase 3 were detected by western blotting. Nrf2, HO‐1, NOX2, and inflammatory factors TNF‐α, IL‐1β, IL‐4, and IL‐10 were detected by real‐time polymerase chain reaction. The results showed that Edaravone dexborneol treatment improved learning and memory performance, neuronal damage, and enhanced antioxidant, inflammation, and apoptosis in CIRI mice. In addition, Edaravone dexborneol induced the activation Nrf2/HO‐1 signaling pathway activation while inhibiting NOX2 expression. Overall, these results indicate that Edaravone dexborneol ameliorates CIRI‐induced memory impairments by activating Nrf2/HO‐1 signaling pathway and inhibiting NOX2.
SIFTR‐ing through the development of cultural awareness at home and abroad
Authors: Guerrero‐Rodríguez Paola , Lomicka Anderson Lara , Lord Gillian 
Published: April 2022

AbstractToday's language learners benefit from cultural awareness, which can be fostered through experiences both at home and during study abroad. One approach to exploring culture that has gained popularity has been the use of geolocation technologies, which can help engage students in class and beyond. The sense of community developed through these collaborations can enhance or even recreate the classroom experience in virtual environments. This exploratory project uses a geolocation tool (Siftr, www.siftr.org) in two contexts, at home and abroad, to explore how technology can help foster cultural awareness in these two different contexts. Identified trends suggest that, regardless of context, Siftr can be incorporated in various learning contexts to open pathways to intercultural understanding and help learners intentionally notice their own culture and that of others.
Switchgrass cropping systems affect soil carbon and nitrogen and microbial diversity and activity on marginal lands
Authors: Li Xiufen , Petipas Renee H. , Antoch Amanda A. , Liu Yuan , Stel Holly V. , Bell‐Dereske Lukas , Smercina Darian N. , Bekkering Cody , Evans Sarah E. , Tiemann Lisa K. , Friesen Maren L. 
Published: April 2022

AbstractSwitchgrass (Panicum virgatum L.), as a dedicated bioenergy crop, can provide cellulosic feedstock for biofuel production while improving or maintaining soil quality. However, comprehensive evaluations of how switchgrass cultivation and nitrogen (N) management impact soil and plant parameters remain incomplete. We conducted field trials in three years (2016–2018) at six locations in the North Central Great Lakes Region to evaluate the effects of cropping systems (switchgrass, restored prairie, undisturbed control) and N rates (0, 56 kg N ha−1 year−1) on biomass yield and soil physicochemical, microbial, and enzymatic parameters. Switchgrass cropping system yielded an aboveground biomass 2.9–3.3 times higher than the other two systems (Jayawardena et al., unpublished data) but our study found that this biomass accumulation did not reduce soil dissolved organic C, total dissolved N (TDN), or bacterial diversity. The annual aboveground biomass removal for bioenergy feedstock, however, reduced soil microbial biomass C (MBC) and microbial biomass N (MBN) and bacterial richness in the second and third years; despite this, continuous monocropping of switchgrass improved soil TDN, inorganic N, bacterial diversity, and shoot biomass in the second and/or third years compared with the first year. N fertilization increased aboveground biomass yield by 1.2 times and significantly increased soil TDN, MBN, and the shoot biomass of switchgrass compared with the unfertilized control. Locations with higher C and N contents and lower C:N ratio had higher aboveground biomass, MBC, MBN, and the activity of BG, CBH, and UREA enzymes; by contrast, locations with higher pH had higher soil TDN and activity of NAG and LAP enzymes. Our research demonstrates that switchgrass cultivation could improve or maintain soil N content and N fertilization can increase plant biomass yield. The comprehensive data also can inform future biogeochemical models to successfully implement switchgrass for bioenergy production.
Factors associated with renal function change after unilateral adrenalectomy in patients with primary aldosteronism
Authors: Lu Yu‐Cheng , Liu Kao‐Lang , Wu Vin‐Cent , Wang Shuo‐Meng , Lin Yen‐Hung , Chueh Shih‐Chieh Jeff , Wu Kwan‐Dun , Huang Kuo‐How ,   the Taiwan Primary Aldosteronism Investigation Study Group
Published: April 2022

ObjectivesDecreased glomerular filtration rate has been reported in patients with primary aldosteronism after unilateral adrenalectomy. Glomerular hyperfiltration has been assumed to mask the preoperative subtle renal impairment. In this study, we investigated predictors for decreased estimated glomerular filtration rate after adrenalectomy in patients with primary aldosteronism.MethodsFrom January 2006 through September 2018, 328 patients with confirmatory diagnoses of primary aldosteronism received unilateral laparoscopic adrenalectomy and subsequent follow‐up for 12 months. We prospectively collected related parameters of the clinical outcomes and renal function to identify predictors of renal function impairment at 12 months after surgery.ResultsPatients were stratified into three groups by preoperative estimated glomerular filtration rate level: 144 (43.9%) with estimated glomerular filtration rate ≥90, 130 (39.6%) with estimated glomerular filtration rate within 60–89.9, and 54 (16.5%) with estimated glomerular filtration rate <60 mL/min/1.73 m2. The estimated glomerular filtration rate decreased significantly at the 6th month and remained stable at the 12th month, postoperatively. Patients with estimated glomerular filtration rate ≥90 had better clinical outcome with 59.6% success rate (P = 0.006) among three groups. Multivariate logistic regression analysis indicated that preoperative estimated glomerular filtration rate (odds ratio 1.012, P = 0.02) and hypokalemia (odds ratio 2.018, P = 0.024) were associated with renal impairment at 12th month after adrenalectomy. Multivariate linear regression analysis revealed high preoperative estimated glomerular filtration rate (β = 0.261, P < 0.001), high preoperative systolic blood pressure (β = 0.168, P = 0.003), high level of microalbuminuria (β = 0.024, P = 0.001), and low level of serum potassium (β = −4.883, P = 0.007) were associated with estimated glomerular filtration rate percentage decline at 12th month after adrenalectomy.ConclusionsEstimated glomerular filtration rate declined significantly after adrenalectomy in patients with estimated glomerular filtration rate ≥90. The study provided important information to identify primary aldosteronism patients with higher risk of estimated glomerular filtration rate decline after adrenalectomy and might help to adopt early interventions to improve the outcomes.
Reputational risks in banks: A review of research themes, frameworks, methods, and future research directions
Authors: Adeabah David , Andoh Charles , Asongu Simplice , Gemegah Albert 
Published: April 2022

AbstractThis study examined the research trends on reputational risk in banks using a systematic literature review and network analysis (SLRNA) approach on 35 research articles published between 2010 and 2020. It was found that only developed countries (i.e., the United States and Europe) have been actively contributing to research on reputational risks in banks, suggesting that reputational risks management of banks has not gained the global attention it deserves. Moreover, we identified five broad research themes from the thematic network analysis, namely, reputational risk of operational losses, reputational effects of media tone, performance implications of reputational risk management, management of reputational risk in banks, sustainability practices and reputational risk of banks in the project finance market. Nonetheless, there still a number of areas that require further attention. These include conceptualization of reputational risk management in banks that explore the dynamic and interdependencies in a system thinking framework, the role of corporate governance, environmental and social issues on reputational risk, how sustainability practices shape reputational risk management, the role of political connections in mitigating reputational effect of operational loss events, and how information and communication technology (ICT) mechanisms impact reputational risk management in banks.
Cancer sleep symptom‐related phenotypic clustering differs across three cancer specific patient cohorts
Authors: Kairaitis Kristina , Madut Ayey S. , Subramanian Harini , Trivedi Ritu , Man Hong , Mather Marius , Brand Alison , Elder Elisabeth , Howle Julie , Mann Graham J , Amis Terence C. , De Fazio Anna 
Published: April 2022

SummarySpecific sleep disorders have been linked to disease progression in different cancers. We hypothesised sleep symptom clusters would differ between cancer types. The aim of this study was to compare sleep symptom clusters in post‐treatment melanoma, breast and endometrial cancer patients. Data were collected from 124 breast cancer patients (1 male, 60 ± 15 years, 28.1 ± 6.6 kg/m2), 82 endometrial cancer patients (64.0 ± 12.5 years, 33.5 ± 10.4 kg/m2) and 112 melanoma patients (59 male, 65.0 ± 18.0 years, 29.1 ± 6.6 kg/m2). All patients completed validated questionnaires to assess sleep symptoms, including the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Functional Outcomes of Sleep Questionnaire‐10 (FOSQ‐10). Snoring, tiredness, observed apneas, age, BMI, and gender data were also collected. Binary values (PSQI, ISI, FOSQ), or continuous variables for sleepiness (ESS) and perceived sleep quality (PSQI), were created and sleep symptom clusters were identified and compared across cancer cohorts. Four distinct sleep symptom clusters were identified: minimally symptomatic (n = 152, 47.7%); insomnia‐predominant (n = 87, 24.9%); very sleepy with upper airway symptoms (n = 51, 16.3%), and severely symptomatic with severe dysfunction (n = 34, 11.1%). Breast cancer patients were significantly more likely to be in the insomnia predominant or severely symptomatic with severe dysfunction clusters, whereas melanoma patients were more likely to be minimally symptomatic or sleepy with upper airway symptoms (p <0.0001). Endometrial cancer patients were equally distributed across symptom clusters. Sleep symptom clusters vary across cancer patients. A more personalised approach to the management of sleep‐related symptoms in these patients may improve the long term quality of life and survival.
Heavy metal induced regulation of plant biology: Recent insights
Authors: Sharma Anket , Kapoor Dhriti , Gautam Shristy , Landi Marco , Kandhol Nidhi , Araniti Fabrizio , Ramakrishnan Muthusamy , Satish Lakkakula , Singh Vijay Pratap , Sharma Priyanka , Bhardwaj Renu , Tripathi Durgesh Kumar , Zheng Bingsong 
Published: April 2022

AbstractThe presence of different forms of heavy metals in the earth crust is very primitive and probably associated with the origin of plant life. However, since the beginning of human civilisation, heavy metal use and its contamination to all living systems on earth have significantly increased due to human anthropogenic activities. Heavy metals are nonbiodegradable, which directly or indirectly impact photosynthesis, antioxidant system, mineral nutrition status, phytohormones and amino acid‐derived molecules. Due to the toxic behaviour of some heavy metals, the endogenous status of chemical messengers like phytohormones may get significantly influenced, leading to harmful impacts on plant growth, development and overall yield of the plants. It has been noticed that exogenous application of phytohormones, that is, abscisic acid, salicylic acid, auxins, brassinosteroids, cytokinins, ethylene and gibberellins can positively regulate the heavy metal toxicity in plants through the regulation of the ascorbate–glutathione cycle, nitrogen metabolism, proline metabolisms, transpiration rate, and cell division. Furthermore, it may also restrict the entry of heavy metals into the plant cells, which aids in the recovery of plant growth and productivity. Besides these, some defence molecules also assist the plant in dealing with heavy metal toxicity. Therefore, the present review aims to bridge the knowledge gap in this context and present outstanding discoveries related to plant life supportive processes during stressful conditions including phytohormones and heavy metal crosstalk along with suggestions for future research in this field.
Exploring farm‐to‐restaurant relations and the potential of a local food hub: A case study in the city‐region of Groningen, the Netherlands
Authors: Smaal Sara A. L. 
Published: April 2022

AbstractUrban restaurants are increasingly putting local food on the menu. How do farm‐to‐restaurant relations fit into the local food movement, and how can these collaborations be supported by food policies and programmes of urban governments? Through a qualitative case study in the city‐region of Groningen (The Netherlands), this article explores the values urban restaurants, local food suppliers and urban governments attribute to local food, the trust and barriers these actors experience in their collaborations, and their views on the municipality's preliminary plans for a local food hub. In line with the concepts of reflexive localism and values‐based territorial food networks, and taking into account the perspectives, benefits, pitfalls and conditions uncovered in this study, a farm‐to‐restaurant‐oriented food hub would need to (1) embrace the complex and relational nature of place, (2) foster reciprocal and practical partnerships, (3) negotiate reflexive and values‐based goals and (4) broker between and unburden the involved parties.
Integrating a deep forest algorithm with vector‐based cellular automata for urban land change simulation
Authors: Zhuang Haoming , Liu Xiaoping , Yan Yuchao , Zhang Dachuan , He Jialyu , He Jinqiang , Zhang Xinchang , Zhang Honghui , Li Manchun 
Published: April 2022

AbstractWith the capacity to represent irregular geographical entities precisely, vector‐based cellular automata (VCA) have been extensively employed in urban land change simulation at the land parcel level. However, while more driving factors are considered, modeling the complicated nonlinear relationship between land parcel attributes and multiple land‐use changes is increasingly difficult. Moreover, in VCA, the driving factors are unstructured and cannot be directly modeled by traditional deep learning methods, which can only be applied to structured data processing. In order to address these problems, a new VCA model DF‐VCA that adopts the deep forest (DF) algorithm for mining CA transition rules was proposed to simulate urban land‐use change at the parcel level. The DF algorithm is a new deep learning method that can directly mine high‐level features from unstructured data and obtain accurate land‐use transition rules. The proposed DF‐VCA model was applied to simulate the urban land change in Shenzhen, China. Compared with several traditional VCA models, the DF‐VCA model achieved the best simulation performance at parcel‐level (Figure of Merit = 39.88%), pattern‐level (similarity = 96.47%), and community‐level (correlation coefficient = 0.9269). The results show that the DF‐VCA model with strong representative learning ability could simulate urban land change at fine scales precisely. Furthermore, the proposed DF‐VCA model was applied in Shenzhen's future land change simulations to guide sustainable urban development.