bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Ion Channel-targeted Drugs and Potential of Venom-derived Peptides
as a Therapeutic New Modality
Authors: Okada Toshiaki , Taira Hikaru , Kimura Tadashi 
Published: May 2022

Abstract:
Ion channel function is essential for maintaining life and is involved in various physiological activities. However, various factors such as heredity, aging, wounding, and diseases can cause abnormalities in ion channel function and expression. Such channel abnormalities can interfere with the
healthy activities of the organism and threaten the maintenance of life. There are many types of ion
channels, and their roles are diverse. In recent years, it is becoming clear that ion channels are intrinsically involved in various diseases beyond what has been previously thought. Therefore, it is highly desirable to develop more drugs by increasing various channels for drug discovery and various diseases.
In this review, we will introduce the ion channels currently targeted for drug discovery and the mechanisms by which these channels are involved in diseases, focusing on information compiled on the internet. Currently, the target ion channels for drug development and treating diseases are becoming
more diverse. The drugs under development are not only small molecules, which account for most of
the ion channel drugs developed to date, but also different types of drugs, such as antibodies, peptides,
and oligonucleotides. Due to low specificity, many existing ion channel drugs have side effect problems. Diversification of drugs may facilitate the resolution of these problems, and venom-derived peptide drugs are a promising class of future agents that can contribute to this end. In the last part of this
review, the status of drug development of venom-derived peptides will also be discussed.
ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic
Tool
Authors: Amaldoss Maria John Newton , Sorrell Charles Christopher 
Published: May 2022

Abstract:
The term "reactive oxygen species" (ROS) refers to a family of extremely reactive molecules.
They are crucial as secondary messengers in both physiological functioning and the development
of cancer. Tumors have developed the ability to survive at elevated ROS levels with significantly
higher H2O2 levels than normal tissues. Chemodynamic therapy is a novel approach to cancer treatment
that generates highly toxic hydroxyl radicals via a Fenton/Fenton-like reaction between metals
and peroxides. Inorganic nanoparticles cause cytotoxicity by releasing ROS. Inorganic nanoparticles
can alter redox homoeostasis by generating ROS or diminishing scavenging mechanisms. Internalized
nanoparticles generate ROS in biological systems independent of the route of internalisation. This
method of producing ROS could be employed to kill cancer cells as a therapeutic strategy. ROS also
play a role in regulating the development of normal stem cells, as excessive ROS disturb the stem
cells' regular biological cycles. ROS treatment has a significant effect on normal cellular function. Mitochondrial
ROS are at the centre of metabolic changes and control a variety of other cellular processes,
which can lead to medication resistance in cancer patients. As a result, utilising ROS in therapeutic
applications can be a double-edged sword that requires better understanding.
Analisis kemampuan metakognitif siswa SMA kelas XI program IPA dalam pemecahan masalah matematika
Authors: Suryaningtyas Sri , Setyaningrum Wahyu 
Published: May 2022

Penelitian ini bertujuan untuk mendeskripsikan kemampuan metakognitif siswa SMA kelas XI program IPA dalam memecahkan masalah matematika. Penelitian ini merupakan penelitian survei yang melibatkan siswa SMA negeri di Kabupaten Kulon Progo dan Gunungkidul. Sampel penelitian adalah 160 siswa kelas XI program IPA yang berasal dari 6 sekolah yang mewakili tiga kategori capaian akademik siswa yaitu tinggi, sedang, dan rendah. Pengambilan sampel menggunakan teknik stratified random sampling. Pengumpulan data dilakukan menggunakan tes dan angket Metacognitive Awarenes Inventory (MAI). Data dianalisis secara kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa 44% siswa mempunyai kemampuan metakognitif tinggi, 10% siswa mempunyai kemampuan metakognitif sedang, dan 46% siswa mempunyai kemampuan metakognitif rendah. Sebagian besar siswa yang mempunyai kemampuan metakognitif tinggi mampu menggunakan kemampuan metakognitifnya selama memecahkan masalah. Tidak semua siswa yang mempunyai kemampuan metakognitif sedang mampu menggunakan kemampuan metakognitifnya selama memecahkan masalah. Hampir semua siswa yang mempunyai kemampuan metakognitif rendah tidak menggunakan kemampuan metakognitifnya selama memecahkan masalah. Secara keseluruhan siswa kurang maksimal menggunakan kemampuan metakognitif selama memecahkan masalah. AbstractThis study aimed to describe the metacognitive abilities of eleventh-grade high school students in the science program in solving math problems. This study was a survey involving public high school students in Kulon Progo and Gunungkidul Regency, Indonesia. The research sample was 160 students from the eleventh-grade science program from 6 public high schools representing three categories of student academic achievement, namely high, medium, and low. The sample was determined using a stratified random sampling technique. Data collection was carried out using a test and Metacognitive Awareness Inventory (MAI) questionnaire. Data were analyzed quantitatively and qualitatively. The results showed that 44% of students had high metacognition abilities, 10% of students had moderate metacognition abilities, and 46% of students had low metacognition abilities. Most students who had high metacognitive abilities were able to use their metacognitive abilities while solving problems. Not all students who had moderate metacognition abilities were able to use their metacognitive abilities while solving problems. Almost all students who had low metacognition abilities didn’t use their metacognitive abilities while solving problems. Overall, students did not use metacognition skills maximally during problem-solving.
Keefektifan pendekatan contextual teaching learning dan problem solving ditinjau dari prestasi dan kepercayaan diri siswa
Authors: Susanti Usi , Wutsqa Dhoriva Urwatul 
Published: May 2022

Tujuan dari penelitian ini adalah untuk mendeskripsikan keefektifan pendekatan Contextual Teaching and Learning (CTL) dan problem-solving ditinjau dari prestasi belajar dan kepercayaan diri. Penelitian ini merupakan penelitian eksperimen semu dengan populasi semua siswa kelas VII SMP Negeri 1 Yogyakarta Tahun Ajaran 2015/2016 yang terdiri dari delapan kelas. Sampel penelitian dipilih secara acak, dari delapan kelas yang ada terpilih dua kelas yaitu VII A dan VII B. Kelas VII A sebagai kelas eksperimen I diajar dengan pendekatan CTL dan kelas VII B sebagai kelas eksperimen II diajar dengan pendekatan problem solving. Instrumen yang digunakan dalam penelitian ini adalah tes prestasi belajar dan angket kepercayaan diri siswa. Data dianalisis menggunakan one sample t-test yakni digunakan untuk menyelidiki keefektifan pendekatan CTL dan problem solving; dan Multivariate Analysis of Variance (Manova), digunakan untuk menyelidiki perbedaan keefektifan antara pendekatan CTL dan problem solving. Temuan penelitian menunjukkan bahwa pendekatan CTL dan problem solving masing-masing efektif ditinjau dari prestasi belajar, tetapi tidak efektif ditinjau dari kepercayaan diri siswa pada pembelajaran materi himpunan kelas VII. Untuk perbedaan keefektifan, hasil temuan menunjukkan bahwa tidak terdapat perbedaan keefektifan antara pendekatan CTL dan problem solving ditinjau dari prestasi belajar dan kepercayaan diri. The effectiveness of the CTL and problem-solving approaches in terms of the achievement and self-confidence AbstractThe purpose of this study is to describe the effectiveness of Contextual Teaching and Learning (CTL) and problem-solving approaches in terms of achievement and self-confidence. This study was quasi-experiment research with the entire population of the seventh-grade students of State Junior High School 1 Yogyakarta in 2015/2016 which consisted of eight classes. The research sample classes VIIA and VII B were randomly selected from the eight classes. Class VII A as the experiment class I was taught by using the CTL approach and class VII B as the experiment class II was taught by using the problem-solving approach. The instruments of the study were an achievement test and the students’ self-confidence questionnaire. The data were analyzed using a one-sample t-test to investigate the effectiveness of CTL and problem-solving approach; and Multivariate Analysis of Variance (Manova), to investigate the difference between the effectiveness of CTL and problem-solving approaches. The research findings indicate that the CTL and problem-solving approaches each are effective in term of achievement, but it’s not effective in term of and self-confidence in the teaching of the set topic to the seventh-grade students. For differences ineffectiveness, the findings indicate that there is no difference between the CTL and problem-solving approaches in terms of students’ achievement and self-confidence.
Developing and Testing a Protocol for Managing Cardiopulmonary Resuscitation of Patients with Suspected or Confirmed COVID-19: In Situ Simulation Study
Authors: Sowan Azizeh , Heins Jenny , Dayton Christopher , Scherer Elizabeth , Tam Wing Sun , Saikumar Haritha 
Published: May 2022

Background
Resuscitating patients with suspected or confirmed COVID-19 imposes unique challenges to organizations and code blue teams. Studies that applied the American Heart Association (AHA) COVID-19–related Interim Resuscitation Guideline and similar European guidelines are scarce.

Objective
This study aimed to develop and test a cardiopulmonary resuscitation protocol based on the AHA COVID-19–related Interim Resuscitation Guideline.

Methods
The study was conducted as an in situ simulation in a medical intensive care unit. The COVID-19 cardiopulmonary resuscitation protocol was created and validated by 11 health care team members and tested using 4 simulation sessions where 46 code blue team members participated. During the simulation, we observed role clarity, the effectiveness of communication, team dynamics, infection control measures, and the availability of essential supplies and equipment.

Results
The main issues identified in each simulation session were debriefed to the code blue teams and used to further revise the protocol. These include the assignment of tasks, availability of equipment and supplies, and failure of communication between the in-room and out-of-room teams. Solutions included changes in the placement of team members and roles and responsibilities; the creation of an isolation code medication package, a respiratory therapy kit, and an isolation code blue bag; and the use of two-way radios and N-95 masks with eye goggles to enhance communication between the teams.

Conclusions
This study shed light on the challenges to implement the AHA COVID-19–related Interim Resuscitation Guideline. The in situ simulation was an effective approach for rapid training, identifying unreliable equipment and ineffective and inefficient workflow, and managing the complexity of the physical environment.
Pengembangan Wisata Alam Bur Telege
Authors: Adlin Nur Wulan 
Published: May 2022

This article aims to see how the development of Bur Telege tourism began, how the community responded to Bur Telege tourism, and how it impacts the community around tourism locations. The research method used is a qualitative research method with a descriptive type of research. The power collection techniques used are interviews, observation, and documentation. The resource persons in this study were tourism managers, village heads, a village youth, and the community. The results of this study indicate that the formation of Bur Telege tourism originated from the idea of the village youth of Hakim Bale Bujang who was later supported by the community. The community response to this tourism development is very positive because this tour positively impacts the Hakim Bale Bujang community, such as easy access to their area, being economically empowered, and providing jobs for village youths who do not have permanent employment.
Abstrak
Artikel ini bertujuan untuk melihat bagaimana perkembangan pariwisata Bur Telege dimulai, bagaimana respon masyarakat terhadap pariwisata Bur Telege, dan bagaimana dampaknya terhadap masyarakat di sekitar lokasi wisata. Metode penelitian yang digunakan adalah metode penelitian kualitatif dengan jenis penelitian deskriptif. Teknik pengumpulan daya yang digunakan adalah wawancara, observasi, dan dokumentasi. Narasumber dalam penelitian ini adalah pengelola wisata, kepala desa, pemuda desa, dan masyarakat. Hasil penelitian ini menunjukkan bahwa terbentuknya wisata Bur Telege berawal dari ide pemuda desa Hakim Bale Bujang yang kemudian didukung oleh masyarakat. Respon masyarakat terhadap pengembangan wisata ini sangat positif karena wisata ini memberikan dampak positif bagi masyarakat Hakim Bale Bujang, seperti akses mudah ke daerah mereka, pemberdayaan ekonomi, dan penyediaan lapangan pekerjaan bagi pemuda desa yang tidak memiliki pekerjaan tetap.
Nursing Students’ Perception of Patient Safety Culture During the Covid-19 Pandemic – Results of a Pilot Study
Authors: Dominika Kalankova , Daniela Bartonickova , Dominika Holubova , Katarina Ziakova 
Published: May 2022

Abstract

Introduction: The COVID-19 pandemic posed health and social threats and directly affected the quality and safe care. Many nursing students had mandatory practical training in hospitals to help the national system respond to the crisis. The investigation of nursing students’ perceptions of patient safety culture (PSC) might be beneficial in identifying safety areas that need improvement.

Aim: The pilot study aimed to investigate nursing students’ perception of PSC during the second wave of the COVID-19 pandemic.

Methods: The data were collected using the Hospital Survey on Patient Safety Culture - Nursing Students (HSOPS-NS). The HSOPS-NS tool was distributed online via the Google Forms platform between February and April 2021. The respondents studied in the 3rd year of the bachelor’s degree in nursing (n = 66). Three nursing faculties from 3 regions in Slovakia were addressed. Descriptive statistics (mean, SD, frequency) was used for the sample characteristics and the HSOPS-NS tool. The Mann-Whitney U test and the Kruskal Wallis test analysed associations between sociodemographic data. The predictors of outcome dimensions of the HSOPS-NS were analysed by a multiple regression analysis.

Results: The nursing students evaluated the overall patient safety grade as very acceptable. Concerning PSC dimensions, the best-rated dimensions were “Feedback & communication about the error” (55.04%) and “Communication openness” (53.53%). The worst-rated dimensions were “Frequency of events reported” (33.32%) and “Staffing” (35.22%). A significant relationship was found between the perception of PSC and age, current area/unit, awareness of reporting systems, and supervision. The overall patient safety grade, the number of reported events, the number of reported events by nursing students were significantly predicted by several PSC dimensions (p ≤ 0.05).

Conclusions: The nursing students’ perspective on PSC revealed a weak perception of reporting adverse events. The awareness of reporting adverse events requires an increase in theoretical knowledge and the support of nursing students during their clinical training. A regular and comprehensive evaluation of PSC may strengthen patient safety and the overall awareness of patient safety among nursing students.
A Computer Aided Design Software Comparative Study with Applications in Industry 4.0 – Smart Manufacturing
Authors: Ciorap Mariana , Gures Dogan , Dumitraş Cătălin Gabriel 
Published: May 2022

Abstract
The concept Industry 4.0 implies many elements such as CAD/CAM/CAE, simulation, additive fabrication, IoT (internet of things) and it was a result of the demands of the industry in decreasing the period of product designing, flexibility of the design, and quick response to the market demands.. With the help of CAD software, the design period for a new product was reduced by almost 30 percent. Based on this reason, the CAD software family was developed during the last twenty years giving the possibility to create more complex 3D models, parametrization and calculus for product cost or mechanical properties. One of the major drawback in having such a great number of companies that produce CAD software is that each one tries to individualize their own software. We can mention that there are over 150 types of CAD files format. This multitude of types of CAD software makes it necessary to carry out a comparative study to establish criteria for choosing one software or another. In this article we carried out such a study considering three of the most used software based on a case study – the design of a turning cutting tool.
Analysis of the impacts of the COVID-19 pandemic on the drinking milk supply chain in Austria by means of a business process modelling and System Dynamics approach
Authors: Singer Johanna , Kummer Yvonne , Weber Christiane , Strobl Martina , Burtscher Johanna , Domig Konrad J. , Hirsch Patrick 
Published: May 2022

Abstract
Dairy farming is an important branch of agricultural production for the supply of the Austrian population with domestic food. This paper examines the impact of the COVID-19 pandemic on the Austrian drinking milk supply chain. For this purpose, a tripartite approach was chosen consisting of a process description using Business Process Model and Notation (BPMN), a qualitative System Dynamics analysis with a Causal Loop Diagram (CLD), and the use case of the COVID-19 pandemic in the year 2020 in Austria. The results show that the drinking milk supply chain is complex and consists of many individual process steps. However, the number of locations that are passed through during drinking milk production is rather small. The CLD revealed that reinforcing feedback loops occur in the provision of packaging material and the availability of dairy staff. Analysis of the use case showed that the system of dairy production in Austria is stable in the tested scenario, and that the supply chains preserved their function also during the pandemic. Dairies with diverse product ranges were able to react more easily to the massively changed demand situation. The insights gained by this research may be used to increase the resilience of the drinking milk supply chain. Furthermore, the methodological approach can be transferred and used to analyse the supply chains of other foods.
Laugh in Case of Emergency: Framing the Pandemic Through Memes in Italy and Russia
Authors: Marsili Andrea , Shchetvina Anya 
Published: May 2022

Abstract
During the COVID-19 pandemic, meme culture prospered. New topics, styles and problems emerged from meme-sharing, resulting in a specific genre – quarantine memes. Although some of the possible causes could be linked to the lockdown boredom and consequent increase in screen-time among internet users; we argue that the other cause has to be sought in the complex role memes had (and still have) as instruments of symbolic framing.
As De Rycker (2018) put forth, a crisis is a human activity carried out knowingly and intentionally. Understanding the COVID-19 pandemic as a crisis, we aim to analyse quarantine memes as a participatory practice of ‘doing crisis’ – in particular, by framing its meanings and making sense of changes in everyday life.
Quarantine memes exist in the context of uncertainty, risks and fears about people’s health, restrictions of freedom, stress and changes in daily routines. The creation of memes that emerged from this context frames the pandemic and the virus in a variety of ways, not only suggesting different points of view but also establishing norms, encouraging (dis)belief and satirically or creatively commenting on new COVID-related practices.
Using a combination of digital ethnography and content analysis, we observed the meme-related participatory practices of quarantine memes on the most popular webpages in two countries: Russia (VKontakte) and Italy (Facebook). Temporally covering the first wave and the subsequent pandemic containment measures (February-October 2020), we distinguished a set of framing strategies that are suggested via memes by online audiences: alienation, avoidance, awareness-raising, critique, domestication, subversion, escapism and acknowledgement of emotions. Comparing and contrasting the topics and symbolic strategies that emerged in those countries, we showed that symbolic framing via memes is not a straightforward phenomenon, but a long-nuanced process in which different perceptions of the virus overlapped each other and changed through time.
Competitiveness of the Southeast European Countries in the Conditions of the Globalization
Authors: Živković Jelena 
Published: May 2022

Abstract
Globalization is a process often identified with the economic integration of countries, the creation of a single market while neglecting other aspects of globalization. Besides its economic dimension, The KOF index of globalization includes the social and political dimensions. One of the questions is how the countries manage to strengthen their competitive position in the international market in the age of globalization. Is it challenging to maintain a stable competitive position in the conditions of greater connection of countries and in what form? For this reason, the paper deals with the change of the Global Competitiveness Index, a renowned measure of the competitiveness of national economies according to the methodology of the World Economic Forum, under the influence of increased economic globalization of Southeast European countries. It also estimates the impact of globalization, or its economic, social and political dimension on the economic growth of Southeast European countries, which is one of the requirements for successful positioning on the international economic scene.
The Importance of Fruit and Vegetables in the External Trade of the Republic of Serbia
Authors: Marković Milan , Marjanović Ivana 
Published: May 2022

Abstract
The main goal of the research is to consider and compare the importance of fruits and vegetables in external trade in goods of the Republic of Serbia. According to the Standard International Trade Classification (SITC), “Vegetables and Fruit” is a division that is dominant in Serbian exports of agricultural and food products, and it is necessary to investigate its competitiveness. The key tools used in the analysis are the coverage of imports by exports, then the Contribution to the Trade Balance (CTB) index, as well as the analysis of unit values of exports and imports, in order to compare and evaluate the structure of external trade in fruits and vegetables. The results show that fruit, according to all indicators, has a significantly higher competitiveness compared to vegetables, as well as a higher importance in external trade of goods. This knowledge can serve the creators of agricultural policy to favour the production and exports of fruit products because they can radically improve the structure of total exports, especially when it comes to processed products. Since this is a perennial plantation, the results cannot be expected in a shorter period of time. The previous research has not specifically considered the importance of this segment of agri-food exports and its internal competitiveness (having in mind the applied indicators), which is the main benefit of the study within this paper.