bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Receiving Longer Than Recommended Therapy Among Culture-Negative Pulmonary Tuberculosis Patients
Authors: Tsang Clarisse A , Patel Neha N , Stout Jason E , Fernando Robyn , Pratt Robert , Goswami Neela D 
Published: November 2022

Abstract

Background
US tuberculosis (TB) guidelines recommend treatment ≥6 months with a regimen composed of multiple effective anti-TB drugs. Since 2003, a 4-month regimen for a specific subset of TB patients has also been recommended.

Methods
We used 2011–2018 US National Tuberculosis Surveillance System data to characterize factors associated with 4-month (111–140 days) therapy among adult patients who had completed treatment and were potentially eligible at that time for 4-month therapy (culture-negative pulmonary-only TB, absence of certain risk factors, and initial treatment that included pyrazinamide). We used modified Poisson regression with backward elimination of main effect variables to calculate adjusted relative risks (aRRs).

Results
During 2011–2018, 63 393 adults completed TB treatment: 5560 (8.8%) were potentially eligible for 4-month therapy; of these, 5560 patients (79%) received &gt;4-month therapy (median, 193 days or ∼6 months). Patients with cavitary disease were more likely to receive &gt;4-month therapy (aRR, 1.10; 95% CI, 1.07–1.14) vs patients without cavitary disease. Patients more likely to receive 4-month therapy included patients treated by health departments vs private providers only (aRR, 0.94; 95% CI, 0.91–0.98), those in the South and West vs the Midwest, non-US-born persons (aRR, 0.95; 95% CI, 0.91–0.99) vs US-born persons, and aged 25–64 years vs 15–24 years.

Conclusions
Most patients potentially eligible for 4-month therapy were treated with standard 6-month courses. Beyond clinical eligibility criteria, other patient- and program-related factors might be more critical determinants of treatment duration.
Making the ‘business case’: vocabularies of motive and clean tech innovation in the hidden developmental state
Authors: Kallman Meghan Elizabeth , Frickel Scott 
Published: November 2022

AbstractThis article analyzes the hidden developmental state (HDS) from a cultural perspective, exploring the values and vocabularies of motive among technology experts, managers and government officials involved in state-led innovation. We consider the rollout of smart meters in Washington State, an endeavor primarily funded by the American Recovery and Reinvestment Act of 2009 (ARRA). Mobilizing evidence from 70 key informant interviews, we develop two related arguments. First, despite its ‘hiddenness’, the ARRA provided cash injections that shifted utility business models and electricity markets from fossil fuels infrastructure and toward renewable technologies by funding projects rather than organizations. The funding structure enabled engineers and managers to bypass conventional industry gatekeepers. Second, this shift was conditioned by a traditional ‘business case’ discourse, which functioned as a rhetorical lubricant, legitimating risky innovation and disguising individual and organizational values that run against established norms. A concluding discussion highlights the implications for future research.
Maintaining Skin Integrity in Neonates with Sunflower Seed Oil and Liquid Vaseline: A Prospective Randomized Controlled Study
Authors: Karakoç Ilgın Bahar , Ekici Behice 
Published: November 2022

ABSTRACT

OBJECTIVE
To test the effectiveness of sunflower seed oil (SSO) and liquid Vaseline (LV) in maintaining skin integrity in term and preterm neonates in the neonatal ICU. Because the skin of the neonate is still immature, disruption of skin integrity is a commonly observed problem.

METHODS
In this randomized controlled study, 90 preterm and term neonates in the neonatal ICU of a state hospital were equally divided into three groups. The skin condition of the neonates in all three groups was assessed using the Neonatal Skin Condition Score (NSCS); assessments were made a total of nine times at 48-hour intervals. The skin of the neonates in the first group was moisturized with SSO, and the second group was moisturized with LV, once a day, a total of 16 times. Moisturizer was not applied to the skin of the third group of neonates (the control group).

RESULTS
The median gestational age was 37.0 weeks (range, 36.0–38.0 weeks). After the third evaluation, the median NSCS scores for the neonates in the SSO and LV groups were significantly lower than for those in the control group (P < .001). The control group’s median NSCS scores did not change throughout the period of the study.

CONCLUSIONS
Both SSO and LV are harmless to the skin of neonates and can be used to maintain their skin integrity. More advanced studies are needed to evaluate the effects of topical oils on maintaining skin integrity.
Immediate Weight-Bearing Following Biplanar Plating of Periprosthetic Femoral Fractures
Authors: Thomas Rachel A. , Pan Tommy , Garner Matthew R. 
Published: November 2022

Purpose:
Femoral fractures in geriatric patients have a high 1-year mortality rate. Early mobilization without restrictions and full weight-bearing in elderly periprosthetic femoral fractures may improve mortality, morbidity, and accelerate functional recovery. The purpose of this study was to evaluate periprosthetic femoral fractures treated with biplanar plating and early ambulation.

Materials and Methods:
We conducted a retrospective study of periprosthetic femoral fractures treated with biplanar plating and immediate weight-bearing over a 4-year period. All patients were treated with anatomic reduction and primary bone healing, with biplanar fixation through a single, lateral-based incision. The primary outcome was radiographic union. Secondary outcomes were preinjury level and postinjury level of functional independence and need for revision surgery.

Results:
Seven patients met the inclusion criteria. The average age was 79.7 (range, 63 to 88) years. The average follow-up period was 18 months. Bony union occurred in all patients after the index procedure, with no revision surgeries documented. Five patients (71%) returned to preoperative ambulatory status, and all patients returned to their preoperative living environment.

Conclusion:
Our study supports the possibility of immediate weight-bearing in geriatric periprosthetic femur fractures treated with anatomic reduction and biplanar plating through a single lateral-based incision, although additional studies are needed.
Chronic Myopathy as the Initial Manifestation of Thyrotoxicosis: A Report of 2 Cases
Authors: Prado Mario B. , Adiao Karen Joy B. 
Published: November 2022

Abstract

Introduction:
Rarely, hyperthyroidism will initially present with chronic myopathy characterized by progressive and sometimes fluctuating proximal muscle weakness, along with elevated creatine kinase and myopathic pattern in the electromyogram, mimicking other muscle and neuromuscular junction disorders with poorer prognosis.

Cases:
Here, we present 2 young patients who complained of 1–4 months duration of chronic proximal muscle lower extremity weakness, supported by elevated creatine kinase and myopathic pattern in electromyogram, who later found to have markedly low thyroid-stimulating hormone, high free T3 and free T4, enlarged thyroid gland on ultrasound, and elevated anti–thyroid-stimulating hormone receptor antibody, characteristic of Grave disease.

Conclusions:
Although rare, thyrotoxicosis should always be ruled out in a patient with chronic myopathy because this has better prognosis than other primary muscle conditions presenting similarly.
Electrophysiology and Magnetic Resonance Neurography Findings of Nontraumatic Ulnar Mononeuropathy From a Tertiary Care Center
Authors: Raj Kishan , Radhakrishnan Divya M. , Bala Parthiban , Garg Ajay , Das Animesh , Shukla Garima , Goyal Vinay , Srivastava Achal Kumar 
Published: November 2022

Abstract

Background:
Ulnar nerve is frequently involved in mononeuropathies of the upper limb. Ulnar neuropathies have been diagnosed conventionally using clinical and electrophysiological findings. Physicians opt for nerve imaging in patients with ambiguous electrophysiological tests to gain additional information, identify etiology and plan management.

Objectives:
The aim of this study was to describe the electrophysiological and the magnetic resonance neurography (MRN) findings in patients with nontraumatic ulnar neuropathy.

Methods:
All consecutive patients with suspected nontraumatic ulnar mononeuropathy were recruited; clinical assessment and electrophysiological studies (EPSs) were done in all. After EPS, patients with localization of lesion along the ulnar nerve underwent MRN.

Results:
All 39 patients recruited had clinical findings suggestive of ulnar neuropathy; Electrophysiological confirmation was possible in 36/39 (92.30%) patients. Localization of ulnar nerve lesion to elbow and wrist was possible in 27 (75%) and 9 (25%) patients, respectively. MRN was done in 22 patients; a lesion was identified in 19 of 22 (86.36%) ulnar nerves studied. Thickening and hyperintensity in T2 W/short TI inversion recovery images of ulnar nerve at the level of olecranon, suggesting ulnar neuropathy at elbow, was the commonest (8/22) imaging finding.

Conclusions:
MRN acts as a complimentary tool to EPS for evaluating nontraumatic ulnar neuropathy. By identifying the etiology, MRN is likely to modify the management decision.
Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review
Authors: Zebhauser Paul Theo , Hohn Vanessa D. , Ploner Markus 
Published: November 2022

Abstract
Reliable and objective biomarkers promise to improve the assessment and treatment of chronic pain. Resting-state electroencephalography (EEG) is broadly available, easy to use, and cost efficient and, therefore, appealing as a potential biomarker of chronic pain. However, results of EEG studies are heterogeneous. Therefore, we conducted a systematic review (PROSPERO CRD42021272622) of quantitative resting-state EEG and magnetoencephalography (MEG) studies in adult patients with different types of chronic pain. We excluded populations with severe psychiatric or neurologic comorbidity. Risk of bias was assessed using a modified Newcastle–Ottawa Scale. Semiquantitative data synthesis was conducted using modified albatross plots. We included 76 studies after searching MEDLINE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and EMBASE. For cross-sectional studies that can serve to develop diagnostic biomarkers, we found higher theta and beta power in patients with chronic pain than in healthy participants. For longitudinal studies, which can yield monitoring and/or predictive biomarkers, we found no clear associations of pain relief with M/EEG measures. Similarly, descriptive studies that can yield diagnostic or monitoring biomarkers showed no clear correlations of pain intensity with M/EEG measures. Risk of bias was high in many studies and domains. Together, this systematic review synthesizes evidence on how resting-state M/EEG might serve as a diagnostic biomarker of chronic pain. Beyond, this review might help to guide future M/EEG studies on the development of pain biomarkers.
DRESS syndrome: an unlikely diagnosis with an unlikely cause
Authors: Soares Sofia Garcês , Mendes M. H. , Pinto-Lopes P. 
Published: November 2022

Abstract
Drug reaction with eosinophilia and systemic symptoms syndrome is a rare and severe adverse drug reaction which is potentially life-threatening. We report a case of a 66-year-old male, with no prior history of allergies, who went to the emergency department with fever, headache and a rash, 12 days following receiving metronidazole for 7 days. He had no recent trips, contact with sick people or animals. The authors aim to alert to an uncommon and serious syndrome caused by an unlikely drug.
The efficiency of the EmERGE platform for medically stable people living with HIV in Portugal
Authors: Beck Eduard J. , Mandalia Sundhiya , Yfantopoulos Platonas , Jones Christopher I. , Bremner Stephen , Whetham Jennifer , Cunha Ana Sofia , Teofilo Eugenio , Rodrigues Goncalo , Borges Margarida ,   on behalf of the EmERGE Consortium
Published: November 2022

Abstract

Background:
The aim of this study was to calculate the cost-effectiveness of the EmERGE Pathway of Care for medically stable people living with HIV in the Hospital Capuchos, Centro Hospitalar Universitário de Lisboa Central (HC-CHLC). The app enables individuals to receive HIV treatment information and communicate with caregivers.

Methods:
This before-and-after study collected the use of services data 1 year before implementation and after implementation of EmERGE from November 1, 2016, to October 30, 2019. Departmental unit costs were calculated and linked to mean use of outpatient services per patient-year (MPPY). Annual costs per patient-year were combined with primary (CD4 count; viral load) and secondary outcomes (PAM-13; PROQOL-HIV).

Results:
Five hundred eighty-six EmERGE participants used HIV outpatient services. Annual outpatient visits decreased by 35% from 3.1 MPPY (95% confidence interval [CI]: 3.0–3.3) to 2.0 (95% CI: 1.9–2.1) as did annual costs per patient-year from €301 (95% CI: €288–€316) to €193 (95% CI: €182–€204). Laboratory tests and costs increased by 2%, and radiology investigations decreased by 40% as did costs. Overall annual cost for HIV outpatient services decreased by 5% from €2093 (95% CI: €2071–€2112) to €1984 (95% CI: €1968–€2001); annual outpatient costs decreased from €12,069 (95% CI: €12,047–€12,088) to €11,960 (95% CI: €11,944–€11,977), with 83% of annual cost because of antiretroviral therapy (ART). Primary and secondary outcome measures did not differ substantially between periods.

Conclusions:
The EmERGE Pathway produced cost savings after implementation—extended to all people living with HIV additional savings are likely to be produced, which can be used to address other needs. Antiretroviral drugs (ARVs) were the main cost drivers and more expensive in Portugal compared with ARV costs in the other EmERGE sites.
A Bibliometric Analysis of Scholarly Activity of Authors of Research Articles Published in the Journal of Physician Assistant Education from 2011-2020
Authors: Bouton Marcia , Halasy Michael 
Published: November 2022

Introduction
The purpose of this study was to analyze bibliometric data and trends of author contributions to the Journal of Physician Assistant Education (JPAE) from 2011-2020.

Methods
Author data were collected from JPAE research articles published from 2011-2020. Publication history and h-index were obtained from Scopus. Data collected included first authors, last authors, and PA authors as well as trends in publications in JPAE. Descriptive statistics, ANOVA, and Wilcoxon rank-sum tests were completed.

Results
From 2011-2020, 200 research articles were published in JPAE; the volume was constant. Of 698 authors listed, 374 were physician assistants (PAs). Overall, contributing authors had a mean publication number of 19.6 (1-327) compared to 12.1 (1-163) for PAs. First and last PA authors had mean publication numbers of 13.2 and 16.1, respectively, and an average h-index of 3.2 and 4.4, respectively. The overall author h-index was 5.2. The mean number of publications for non-PA last authors was 32.9. Publication to h-index proportion was similar between PAs and other authors. The top 25th percentile of PA authors published >9 indexed documents, 3 times the number published by those in the 1-75th percentile.

Discussion
PA author articles in JPAE from 2011 to 2020 were fewer than those by non-PAs but were as likely to have a proportionate h-index. PAs listed as first and last author were highly published. Trends suggest that when PA first authors work with PA last authors, there may be a more egalitarian relationship, and mentorship patterns may also exist within these groups. Increasing publication numbers from 2011 to 2020 for PA first and last authors indicates increasing academic contribution.
The treatment of aneurysmal bone cysts
Authors: van Geloven Thomas P.G. , van de Sande Michiel A.J. , van der Heijden Lizz 
Published: November 2022

Purpose of review
Aneurysmal bone cysts are rare, locally aggressive bone tumors. Optimal treatment of ABCs is still matter of debate as therapies including sclerotherapy, selective arterial embolization and systemic treatment with denosumab are increasingly utilized, in addition to or instead of traditional curettage. The purpose of this review is to discuss current concepts and difficulties in diagnosing and treating primary ABCs, based on latest available literature.

Recent findings
In diagnostics, multiple new fusion partners of USP-6 have been described on next-generation sequencing specifically for primary ABCs. In a recent systematic review, failure rates of percutaneous injections and surgery were comparable. In a literature review, the use of denosumab seemed effective but resulted in multiple cases of severe hypercalcemia in children.

Summary
Accurately diagnosing primary ABC is crucial for treatment decisions. Curettage remains a valid treatment option, especially with adjuvant burring, autogenous bone grafting and phenolization. Percutaneous sclerotherapy represents a solid alternative to surgery, with polidocanol showing good results in larger studies. Systematic therapy with denosumab exhibits favorable results but should be reserved in the pediatric population for unresectable lesions, as it may result in severe hypercalcemia in children. When selecting a treatment option, localization, stability and safety should be considered.
Normothermic regional perfusion for donation after circulatory death donors
Authors: Pasrija Chetan , Tipograf Yuliya , Shah Ashish S. , Trahanas John M. 
Published: November 2022

Purpose of review
This review is intended to provide an update on the logistics, technique, and outcomes associated with normothermic regional perfusion (NRP), as well as provide a discussion of the associated ethical issues.

Recent findings
There has been renewed interest in utilizing NRP to increase quality and availability of organs from donation after circulatory death (DCD) donors. Our institution has increasing experience with thoraco-abdominal NRP (TA-NRP) in controlled DCD donors (cDCD), whereas abdominal NRP (A-NRP) has been used with success in both cDCD and uncontrolled DCD (uDCD). There is increasing evidence that NRP can be conducted in a practical and cost-efficient manner, and that the organ yield may be of better quality than standard direct procurement and perfusion (DPP).

Summary
NRP is increasingly successful and will likely prove to be a superior method for cDCD recovery. However, before TA-NRP can be widely accepted the ethical debate surrounding this technique must be settled.

Video abstract

http://links.lww.com/COOT/A11
A Focus Group Study of Retirement-Age Nurses: Balancing Tension and a Love of Nursing in a Changing Healthcare Environment
Authors: Slusser Kim , Knobf M. Tish , Linsky Sarah , Kaisen Ann , Parkosewich Janet , Sterne Priscilla , Johnson Cynthia , Carley Jacqueline , Beckman Beth 
Published: November 2022

OBJECTIVE
The aims of this study were to explore the experience of retirement-age nurses and identify decision-making factors and innovations to enhance retention.

BACKGROUND
A national shortage of nurses has created challenges to preserving quality patient care and level of nursing competency and managing turnover costs.

METHODS
A qualitative study using focus groups was conducted of nurses 55 years or older who were working or recently retired. Data were audiotaped and transcribed verbatim, with content analysis used to code in an iterative process until consensus was reached.

RESULTS
The tension of balancing the love of patient care within a changing healthcare system was described. Patient acuity, competing roles, and the centrality of computers were stressors and integrally related. Flexibility in work schedules and new practice models were important to retirement decision making for work-life balance and retention.

CONCLUSION
Passion for patient care dominated decisions to continue working. Innovations in practice models and scheduling offer opportunities to enhance the retention of experienced nurses.
Development and Psychometric Testing of a Leadership Competency Assessment
Authors: Ecoff Laurie , Stichler Jaynelle F. 
Published: November 2022

OBJECTIVE
This article discusses the development and psychometric testing of the Nursing Leadership Competency Assessment (LCA).

BACKGROUND
Several leadership assessments are available for purchase, which are aligned with professional organizations. A competency-based leadership assessment is needed to identify the developmental needs of nurse leaders. Competent and confident nurse managers are critical to ensure positive relationships between nurse managers and clinical nurses.

METHODS
A multimethod approach was used to develop and test psychometric properties of the LCA. Items were drawn from 8 sources identifying nurse leader competencies.

RESULTS
The 76-item assessment had a Cronbach's α of 0.99. Confirmatory factor analysis supported 6 hypothesized factors (domains): leading self, people, organizations, change, innovation, and globally. Subscale reliabilities ranged from α = 0.87 to α = 0.98.

CONCLUSIONS
The LCA has demonstrated utility in assessing nurse leader competencies and guiding the development of educational opportunities in targeted content areas for specific leadership roles.
A large superficial spreading melanoma with a secondary growth of fast-growing nodular melanoma: a case report from Syria
Authors: Al-Dabbagh Jacob , Al-Soufi Lina , Hasan Luna , Al-Shehabi Zuheir 
Published: November 2022

Introduction:
Cutaneous melanoma (CM) is a cancer of melanocytes that has a poor prognosis and can metastasize to any organ.

Presentation of case:
Here, we report a unique case of a 59-year-old Syrian male with a nodular melanoma (NM) that grew and varied rapidly on a large superficial spreading melanoma (SSM), which was a pigmented lesion that lasted for 24 years on his trunk. The lesion developed on a part of his body that had not been exposed to the sun or any artificial sources of ultraviolet radiation. His personal and family history of melanoma and nonmelanoma skin cancer were negative. The histopathologic evaluation, along with the immunohistochemistry examination, confirmed the diagnosis.

Clinical discussion:
SSM and NM are the most common subtypes of CM.
NM has a more rapid growth rate and more aggression compared to SSM, and it tends to be more invasive, ulcerated, and fatal than SSM.

Conclusion:
Despite the advanced stage of the NM and the large size of the lesion, no metastasis or lymphadenopathy had been found during the patient’s follow-up.