bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using machine learning models for cuffless blood pressure estimation with ballistocardiogram and impedance plethysmogram
Authors: Liu Shing-Hong , Sun Yao , Wu Bo-Yan , Chen Wenxi , Zhu Xin 
Published: February 2025

IntroductionBlood pressure (BP) serves as a crucial parameter in the management of three prevalent chronic diseases, hypertension, cardiovascular diseases, and cerebrovascular diseases. However, the conventional sphygmomanometer, utilizing a cuff, is unsuitable for the approach of mobile health (mHealth).MethodsCuffless blood pressure measurement, which eliminates the need for a cuff, is considered a promising avenue. This method is based on the relationship between pulse arrival time (PAT) parameters and BP. In this study, pulse transit time (PTT) was derived from ballistocardiograms (BCG) and impedance plethysmograms (IPG) obtained from a weight-fat scale. This study aims to address two challenges using deep learning and machine learning technologies: first, identifying BCG and IPG signals with good quality, and then extracting PTT parameters from them to estimate BP. A stacked model comprising a one-dimensional convolutional neural network (1D CNN) and gated recurrent unit (GRU) was proposed to classify the quality of BCG and IPG signals. Seven parameters, including calibration-based and calibration-free PTT parameters and heart rate (HR), were examined to estimate BP using random forest (RF) and XGBoost models. Seventeen healthy subjects participated in the study, with their BP elevated through exercise. A digital sphygmomanometer was employed to measure BP as reference values. Our methodology was validated using data collected from our custom-made device.ResultsThe results demonstrated a signal quality classification accuracy of 0.989. Furthermore, in the five-fold cross-validation, Pearson correlation coefficients of 0.953 ± 0.007 and 0.935 ± 0.007 were achieved for systolic BP (SBP) and diastolic BP (DBP) estimations, respectively. The mean absolute differences (MADs) of XGBoost model were calculated as 3.54 ± 0.34 and 2.57 ± 0.17 mmHg for SBP and DBP, respectively.DiscussionThe proposed method significantly improved the accuracy of cuffless BP measurement, indicating its potential integration into weight-fat scales as an unconstrained device for effective utilization in mHealth applications.
The tone of teachers’ melody and wellbeing in digital space
Authors: Mirzapour Fatemeh , Şengül Mehmet , Curle Samantha 
Published: February 2025

IntroductionEducational technology has become an essential element for improving education. To achieve this goal, teachers are required to have the necessary skills for integrating technology in their educational activities which in turn can be stressful for them. So, this phenomenological study aimed to investigate the positive and negative impacts of technology on teachers’ physical and social aspects of well-being.MethodsThe study was conducted with 12 teachers (seven females and five males) teaching in different high schools in Tabriz, Iran. Six had a BA, and six had a master’s degree with at least 5 years of teaching experience. Semi-structured interviews and a narrative frame were used to gather data. MAXQDA version 2022 was used to analyze the collected data.ResultsThe results revealed that implementing digital tools had positive and negative impacts on teachers’ physical and social well-being. Positive effects on physical well-being were saving time and energy, and brain activation, but exhaustion, increased health risk, and reduced productivity were the negative ones. Besides, teachers experienced positive social well-being, enabling communication among people across the globe, and easier access and transfer of information. Negative social well-being included adverse effects on child-family relationships and reduced face-to-face interaction.DiscussionTo develop healthy habit of technology use, teachers should have information regarding the positive and negative impacts of technology on their physical and social well-being.
Simulation of potential suitable areas and analysis of natural reserves for four species of Taxus in southern China
Authors: Zhou Yuchen , Liu Mu , Hu Juhua , Xie Guanhong , Shao Yakui 
Published: February 2025

IntroductionIn southern China, four species of the Taxus genus are distributed, and identifying their suitable habitats plays an important role in species conservation.MethodsThis study used the MaxEnt model to simulate and predict the potential suitable habitat distribution for these four species. The prediction model utilized 257 occurrence points from the four yew species, along with historical climate and topographic data, and incorporated the distribution of nature reserves in China. The model’s accuracy was validated using the Area Under the Receiver Operating Characteristic Curve (AUC) to compare the effect of different function models on prediction accuracy.ResultsThe results showed that the AUC values for all four yew species exceeded 0.9, indicating a high level of reliability in the model predictions. The high-suitability area for Taxus wallichiana var. chinensis is 13,943.62 km2, with nature reserves covering 7.49% of this area; Taxus wallichiana var. mairei has a high-suitability area of 11,950.97 km2, with a coverage rate of 2.44%; Taxus wallichiana has a high-suitability area of 9,784.43 km2, with a coverage rate of 10.52%; and Taxus yunnanensis has a high-suitability area of 7,226.57 km2, with a coverage rate of 6.47%. The high-suitability areas for T. wallichiana var. chinensis are concentrated in the Qinling, Wuyi, and Hengduan mountain ranges, while T. wallichiana var. mairei has a broader distribution, primarily in the Wuyi, Qinling, Hengduan, and southeastern Himalayas. The distributions of T. wallichiana and T. yunnanensis are concentrated in the Hengduan Mountains and southeastern Himalayas.DiscussionThe study suggests expanding the network of protected areas, constructing ecological corridors, and introducing cultivation efforts to enhance population stability within high-suitability zones. For T. wallichiana var. mairei and T. wallichiana var. chinensis, it is recommended to attempt more reintroduction efforts, while for T. wallichiana and T. yunnanensis, habitat protection should be prioritized. The establishment of additional natural protected areas and the construction of ecological corridors linking these protected areas are important ways to strengthen the conservation of yew species.
Inhibition of renin-angiotensin system attenuates type I alveolar epithelial cell necroptosis in rats after hyperbaric hyperoxic exposure
Authors: Han CuiHong , Zhang PeiXi , Liu Ying , Xu JiaJun , Yu XuHua , Wen YuKun , Wang ShiFeng , Liu WenWu 
Published: February 2025

ObjectiveThere is evidence showing both necroptosis and activation of renin-angiotensin system (RAS) are involved in the pathogenesis of hyperbaric hyperoxic lung injury (HLI). This study aimed to investigate whether RAS activation can induce lung cell necroptosis and the cell specificity of necroptosis in the lung in case of hyperbaric HLI.MethodsMale SD rats were randomly assigned into control group (n = 12), HLI group (n = 18), captopril group (n = 18), and valsartan group (n = 18). Rats were pre-treated with intraperitoneal captopril (50 mg/kg) or intragastrical valsartan (30 mg/kg) for 3 days before hyperbaric exposure. Then, animals were exposed to 99.9% oxygen at 250 kPa for 6 h to induce HLI. After hyperbaric exposure, lung function was non-invasively detected, and then animals were sacrificed for the detection of wet to dry ratio of the lung, blood gas and lung inflammatory factors, and lung tissues were collected for double immunofluorescence staining. Statistical analysis was performed with one way analysis of variance.ResultsEither valsartan or captopril pre-treatment could inhibit lung edema, improve blood gas (0 h) and lung function (48 h), and reduce pro-inflammatory factors in the lung. In addition, valsartan or captopril pre-treatment could inhibit AGT1 expression and lung cell necroptosis, and type I alveolar epithelial cells (AECs) were the major cell type experiencing necroptosis after hyperbaric hyperoxic exposure.ConclusionOur study indicates inhibition of RAS can suppress the hyperbaric HLI, which may be, at least partially, related to the inhibition of type I AECs necroptosis. Our findings provide new mechanism for the protective effects of RAS inhibition on hyperbaric HLI.
Systematic review of well-being interventions for minority healthcare workers
Authors: Bafna Tanvi , Malik Mansoor , Choudhury Mohua C. , Hu William , Weston Christine M. , Weeks Kristina R. , Connors Cheryl , Burhanullah M. Haroon , Everly George , Michtalik Henry J. , Wu Albert W. 
Published: February 2025

IntroductionHealthcare workers’ well-being is of utmost importance given persistent high rates of burnout, which also affects quality of care. Minority healthcare workers (MHCW) face unique challenges including structural racism and discrimination. There is limited data on interventions addressing the psychological well-being of MHCW. Thus, this systematic review aims to identify interventions specifically designed to support MHCW well-being, and to compare measures of well-being between minority and non-minority healthcare workers.MethodsWe searched multiple electronic databases. Two independent reviewers conducted literature screening and extraction. The Mixed Methods Assessment Tool (MMAT) or Joanna Briggs Institute (JBI) criteria were utilized to assess the methodological quality of studies, based on the study design. Total scores as percentages of criteria met were used to determine overall quality as low (&lt;40%), moderate (40-80%), or high (&gt;80%). For conflicts, consensus was reached through discussion. Meta-analysis was not possible due to heterogeneity of study designs.ResultsA total of 3,816 records were screened and 43 were included in the review. The majority of included studies (76.7%) were of moderate quality. There were no randomized control trials and only one study included a well-being intervention designed specifically for MHCW. Most (67.4%) were quantitative-descriptive studies that compared well-being measures between minority and non-minority identifying healthcare workers. Common themes identified were burnout, job retention, job satisfaction, discrimination, and diversity. There were conflicting results regarding burnout rates in MHCW vs non-minority workers with some studies citing protective resilience and lower burnout while others reported greater burnout due to compounding systemic factors.DiscussionOur findings illuminate a lack of MHCW-specific well-being programs. The conflicting findings of MHCW well-being do not eliminate the need for supports among this population. Given the distinct experiences of MHCW, the development of policies surrounding diversity and inclusion, mental health services, and cultural competency should be considered. Understanding the barriers faced by MHCW can improve both well-being among the healthcare workforce and patient care.
Association between accelerated biological aging and colorectal cancer: a cross-sectional study
Authors: Wang Sai , Wang Keyu , Wang Xiu 
Published: February 2025

BackgroundBiological age (BA) is regarded as a more accurate marker of aging than chronological age and is commonly used to assess associations with age-related diseases. The relationship between BA measures and the colorectal cancer (CRC) has not yet been investigated.MethodsThis study utilized data from the National Health and Nutrition Examination Survey. BA was quantified using the Klemera–Doubal method age (KDMAge) and phenotypic age (PhenoAge), based on 13 common clinical biomarkers. The prevalence of CRC across quartiles of BA indicators was compared using weighted Chi-square tests. Weighted multivariable logistic regression models were used to assess the association between BA indicators and CRC.ResultsA total of 36,684 participants were included. The weighted prevalence of CRC showed a significant and consistent upward trend across ascending quartiles of chronological age, KDMAge, and PhenoAge, even within gender and age subgroups (all P for trend &lt; 0.05). In the total population and gender subgroups, higher quartiles of PhenoAge acceleration showed a higher weighted prevalence of CRC compared to lower quartiles (P for trend &lt; 0.05). Accelerated PhenoAge was significantly associated with a higher prevalence of CRC (OR = 1.767, 95% CI: 1.236–2.524, P = 0.002). However, accelerated PhenoAge was associated with the increased prevalence of CRC only in individuals older than 65 years (OR = 1.655, 95% CI: 1.143–2.397, P = 0.008).ConclusionBiological aging are positively associated with the prevalence of CRC regardless of gender, particularly among the elderly.
Stroke patient rehabilitation: an analysis of the effects of perturbation training combined with hip unloading gait strategies
Authors: Fan Senchao , Ma Yiran , Pan Yu 
Published: February 2025

BackgroundPerturbation training has been proven effective in reducing the risk of falls in stroke patients. When combined with hip unloading walking training, it may further enhance the restoration of walking and balance functions. This study aims to explore the rehabilitation effects of this combined training strategy on walking disabilities in post-stroke patients, with the goal of providing new methodological guidance for clinical rehabilitation.MethodsA randomized controlled trial was conducted at Beijing Tsinghua Changgung Hospital with stroke patients aged 18–70 years. Thirty patients were included and randomly assigned to three groups: the hip unloading walking group, the hip unloading plus perturbation walking group, and the control group, with 10 patients in each. The effectiveness of the training was assessed before and after using the 10-meter walk test and the Berg Balance Scale, along with secondary indicators including the Fugl-Meyer Assessment for Lower Extremity, Functional Ambulation Categories, three-dimensional gait analysis, and the timed up-and-go test.ConclusionCompared to other types of unloading perturbation training methods, hip unloading training exhibits unique superiority. Perturbation training significantly improved the balance and walking efficiency of stroke patients, especially those with severe balance issues, outperforming traditional rehabilitation methods. The unloading group also showed a positive trend, although it did not reach statistical significance. This demonstrates the potential value of perturbation training in stroke rehabilitation.
The dual role of circHIPK3 in cancer and its implications for multiple drugs resistance: a systematic review and computational approach
Authors: Campelo Marcelo Monteiro , Reis-das-Mercês Laís , Vidal Amanda Ferreira , da Silva Felipe Rodolfo Pereira , de Oliveira Ana Carolina Alves , Monteiro José Rogério de Souza , Cabral Caique Guimarães , Noronha Renata Coelho Rodrigues , Pereira Adenilson Leão 
Published: February 2025

BackgroundcircHIPK3 role in cancer as oncogene or tumor suppressor is still debated, therefore, this study aimed to understand the dual role of this circRNA in different cancers. Furthermore, all available evidence of circHIPK3 interactions with sponged-miRNA and RBPs in oncological diseases were systematically gathered to better understand the its functional role in cancer.MethodsPubMed, BioMedCentral, Web of Science, Embase and Scopus databases were searched for articles published until October 2024, following the PRISMA guideline. In computational analysis, miRNAs’ sponged target genes and RBPs were used for gene enrichment in KEGG, REACTOME and Gene Ontology, and TISSUES expression. miRTargetLink 2.0 was used to search for target genes, and STRING v.12.0 for gene enrichment.ResultscircHIPK3 can regulate 33 miRNAs which regulate 399 target genes, and that were mainly enriched in major biological pathways important for cancer development and promoting. circHIPK3/miR-124-3p/miR-637/miR-338-3p are the most well documented interactions in cancers that may control MAPK, Jak/STAT3, Wnt/β-catenin, and PI3K/Akt signaling pathways. circHIPK3 regulates miRNAs that modulate genes responsible for chemoresistance, such as ATP-binding cassette and solute carrier transporters genes, and DNA repair genes. circHIPK3 has binding sites for RBPs, which participate mainly of RNA processing and control, and gene expression regulation. Finally, we believe that it has an onco-circRNA role in most cancers, except in bladder cancer, where it has a TS-circRNA function likely due to the microenvironment permeated by high amounts of hydrogen peroxide.ConclusioncircHIPK3 dysregulation is an important mechanism for cancer establishment, progression and chemoresistance making it an interesting molecule with a potential therapeutic target.
Adverse drug reactions to atezolizumab in combination with bevacizumab in hepatocellular carcinoma patients: an analysis of the food and drug administration adverse event reporting system database
Authors: He Wanming , Tong Lihua , Yuan Yanling , Yang Xia , Yang Wen , Pan Xingxi 
Published: February 2025

PurposeThe objective of the study is to systematically identify and evaluate the adverse drug reactions (ADRs) associated with the combination therapy of systematically and bevacizumab in patients with unresectable hepatocellular carcinoma (HCC).Patients and methodsData were extracted from the Food and Drug Administration (FDA) Adverse Event Reporting System FDA Adverse Event Reporting System database. Disproportionality analysis was conducted using the reporting odds ratio (ROR), proportional reporting ratio (PRR) and Bayesian confidence propagation neural network (BCPNN) of information components (IC). Time-to-onset (TTO) profiles were analyzed using the Weibull shape parameter (WSP) test, while cumulative incidences were assessed using the Kaplan‒Meier method. Valuable preferred term (PT) signals were identified for designated medical event (DME) screening, comparing these signals with system organ class (SOC) analysis.ResultsA total of 2,831 adverse events (AEs) reports were identified in the FAERS database, of which 124 positive AEs were detected across multiple SOCs. The median TTO of AEs was 43 days, with the highest proportion occurring within 0–30 days of TTO (n = 450, 41.17%). The WSP test indicated that patients with abnormal hepatic function and hepatic failure exhibited early failure-type profiles. Ten PT signals consistent with those on the DME list were identified, involving six SOCs.ConclusionOur study provides valuable pharmacological insights for early clinical intervention in managing ADRs and offers significant clinical benefits for HCC patients undergoing combination therapy with atezolizumab and bevacizumab.
Sex-dependent alterations of colonic epithelial permeability: relevance to irritable bowel syndrome
Authors: Larauche Muriel , Mahurkar-Joshi Swapna , Biraud Mandy , Ju Tiffany , Mayer Emeran A. , Chang Lin 
Published: February 2025

IntroductionIncreased intestinal permeability is a possible pathophysiological mechanism of irritable bowel syndrome (IBS). Increased colonic epithelial permeability is associated with visceral nociception in rodents and abdominal pain severity in IBS patients. Although IBS is more common in women, most studies on IBS-associated epithelial dysfunction have largely overlooked sex as a biologic variable.MethodsMen and women with Rome III- and Rome IV-positive IBS and HCs rated GI symptoms including abdominal pain severity at baseline, 24 h prior and immediately post procedure. Epithelial function was assessed ex vivo in Ussing chambers using sigmoid colon biopsies, by monitoring short-circuit current (Isc), transepithelial electrical resistance (TEER) and mucosal permeability to FITC-dextran 4 kDa (FD4). Biopsies tight junction protein mRNA expression was assessed using RNA seq. Statistical analyses included a framework of General Linear Models and linear contrast analyses performed using R software.Results44 IBS patients (66% women, 30 years) and 19 HCs (53% women, 28 years) were enrolled. The proportion of women was not different between groups. As a group, IBS patients exhibited lower TEER compared to HCs (16.9 ± 5.5 vs. 21.5 ± 6.5 Ω/cm2, p = 0.01, FDR = 0.02), but no difference in FD4 serosal concentration or Isc (basal or stimulated). Within men, IBS had lower TEER vs. HCs, but there was no disease difference within women. Independent of diagnosis, women had 1.3-fold lower TEER concentration and 1.5-fold higher FD4 serosal concentration than men. These sex differences were also seen within HCs, although within IBS, FD4 permeability only showed a trend to be higher in women vs. men. Abdominal pain ratings and IBS severity scores were not associated with TEER or FD4 concentration.DiscussionOur study confirms prior reports that IBS patients demonstrate altered sigmoid colonic epithelial function and shows for the first time that these are independent of sex. However, sex differences in sigmoid colonic epithelial function are observed independently of disease status. Further studies are needed to delineate if intestinal permeability interacts with other factors in the pathophysiology of IBS and if these interactions differ by sex.
Antecedents of perceived teacher work ability: a comprehensive model across work and non-work domains
Authors: Hlado Petr , Juhaňák Libor , Harvankova Klara 
Published: February 2025

IntroductionThis study investigates the antecedents of perceived teacher work ability, a critical construct for addressing challenges associated with extending working lives and maintaining sustained professional engagement in the teaching profession. Grounded in the job demands-resources (JD-R) model, this cross-sectional study investigates the relationships between job demands (quantitative, cognitive, and emotional), job resources (supervisor support, coworker support, and autonomy), burnout, and work-life conflict in shaping perceived teacher work ability.MethodsData were obtained from 841 Czech primary and lower secondary school teachers (86.1% female) with a mean age of 45.9 years (SD = 10.8). The full SEM model was developed and estimated based on the proposed hypotheses.ResultsThe findings suggest that burnout is the most significant antecedent of perceived teacher work ability, with quantitative and emotional job demands indirectly influencing it through burnout. While supervisor and coworker support directly enhance perceived teacher work ability, autonomy primarily alleviates quantitative and emotional job demands, thereby indirectly mitigating burnout. Work-life conflict partially mediates the relationship between job demands and burnout but does not directly impact perceived teacher work ability.DiscussionThese results contribute to a deeper understanding of the interplay between job demands, job resources, and burnout in enhancing teachers' capacity to meet the multifaceted demands of their profession effectively.