bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study
Authors: Li Li , Han Zhi-Gang , Qin Peng-Zhe , Liu Wen-Hui , Yang Zhou , Chen Zong-Qiu , Li Ke , Xie Chao-Jun , Ma Yu , Wang Hui , Huang Yong , Fan Shu-Jun , Yan Ze-Lin , Ou Chun-Quan , Luo Lei 
Published: January 2022

Background
The first community transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern (VOC) in Guangzhou, China occurred between May and June 2021. Herein, we describe the epidemiological characteristics of this outbreak and evaluate the implemented containment measures against this outbreak.

Methodology/Principal findings
Guangzhou Center for Disease Control and Prevention provided the data on SARS-CoV-2 infections reported between 21 May and 24 June 2021. We estimated the incubation period distribution by fitting a gamma distribution to the data, while the serial interval distribution was estimated by fitting a normal distribution. The instantaneous effective reproductive number (Rt) was estimated to reflect the transmissibility of SARS-CoV-2. Clinical severity was compared for cases with different vaccination statuses using an ordinal regression model after controlling for age. Of the reported local cases, 7/153 (4.6%) were asymptomatic. The median incubation period was 6.02 (95% confidence interval [CI]: 5.42–6.71) days and the means of serial intervals decreased from 5.19 (95% CI: 4.29–6.11) to 3.78 (95% CI: 2.74–4.81) days. The incubation period increased with age (P<0.001). A hierarchical prevention and control strategy against COVID-19 was implemented in Guangzhou, with Rt decreasing from 6.83 (95% credible interval [CrI]: 3.98–10.44) for the 7-day time window ending on 27 May 2021 to below 1 for the time window ending on 8 June and thereafter. Individuals with partial or full vaccination schedules with BBIBP-CorV or CoronaVac accounted for 15.3% of the COVID-19 cases. Clinical symptoms were milder in partially or fully vaccinated cases than in unvaccinated cases (odds ratio [OR] = 0.26 [95% CI: 0.07–0.94]).

Conclusions/Significance
The hierarchical prevention and control strategy against COVID-19 in Guangzhou was timely and effective. Authorised inactivated vaccines are likely to contribute to reducing the probability of developing severe disease. Our findings have important implications for the containment of COVID-19.
Comparison of percutaneous vs oral infection of hamsters with the hookworm Ancylostoma ceylanicum: Parasite development, pathology and primary immune response
Authors: Bungiro Richard D. , Harrison Lisa M. , Dondji Blaise , Cappello Michael 
Published: January 2022

Background
Hundreds of millions of people in poor countries continue to suffer from disease caused by bloodfeeding hookworms. While mice and rats are not reliably permissive hosts for any human hookworm species, adult Golden Syrian hamsters are fully permissive for the human and animal pathogen Ancylostoma ceylanicum. Similar to humans, hamsters may be infected with A. ceylanicum third-stage larvae orally or percutaneously. Oral infection typically leads to consistent worm yields in hamsters but may not accurately reflect the clinical and immunological manifestations of human infection resulting from skin penetration.

Methodology/Principal findings
In this study we compared host responses following percutaneous infection to those utilizing an established oral infection protocol. Infected hamsters exhibited a dose-dependent pathology, with 1000 percutaneous larvae (L3) causing anemia and adult worm recovery comparable to that of 50 orally administered L3. A delayed arrival and maturity of worms in the intestine was observed, as was variation in measured cellular immune responses. A long-term study found that the decline in blood hemoglobin was more gradual and did not reach levels as low, with the nadir of disease coming later in percutaneously infected hamsters. Both groups exhibited moderate growth delay, an effect that was more persistent in the percutaneously infected group. Fecal egg output also peaked later and at lower levels in the percutaneously infected animals. In contrast to orally infected hamsters, antibody titers to larval antigens continued to increase throughout the course of the experiment in the percutaneous group.

Conclusions/Significance
These results demonstrate that the route of infection with A. ceylanicum impacts disease pathogenesis, as well as humoral and cellular immune responses in an experimental setting. These data further validate the utility of the Golden Syrian hamster as a model of both oral and percutaneous infection with human hookworms.
Prognostic indicators associated with progresses of severe dengue
Authors: Huy Bùi Vũ , Toàn Ngô Văn 
Published: January 2022

BackgroundDengue usually progress abnormally, especially in the critical phase. The main causes of death were shock, severe bleeding and organ failure. The aim of our study was to evaluate prognostic indicators of severe dengue according to the phases of the disease progression.MethodsA cross-sectional study was conducted from July to December 2017 at the National Hospital for Tropical Diseases and the Hospital for Tropical Diseases of Ho Chi Minh City. 326 patients, aged 6 years and over, including 99/326 patients with severe dengue and 227/326 patients with non-severe dengue, hospitalized in the first 3 days of illness, confirmedDenguevirus by the RT-PCR assay have been registered for the study. Clinical manifestations were monitored daily. The hematocrit, white blood cells, platelet, serum albumin, ALT, AST, bilirubin, prothrombin time (PT%, PTs), fibrinogen, aPTT, INR and creatinine were evaluated at two times: febrile phase and critical phase.ResultsIndependent factors associated with severe dengue were identified on multivariate logistic regression models. During the first 3 days of the disease, the prognostic indicators were platelet count ≤ 100 G/L (OR = 2.2; 95%CI: 1.2–3.9), or serum albumin < 35 g/L (OR = 3.3; 95%CI: 1.8–6.1). From day 4–6, the indicator were AST > 400 U/L (OR = 3.0; 95%CI: 1.1–7.9), ALT > 400 U/L (OR = 6.6; 95%CI: 1.7–24.6), albumin < 35 g/L (OR = 3.0; 95%CI: 1.5–5.9), and bilirubin total >17 μmol/L (OR = 4.6; 95%CI: 2.0–10.4).ConclusionTo predict the risk of patients with severe dengue, prognostic laboratory indicators should be indicated consistent with the progression of the disease. During the first 3 days of illness, prognostic indicators should be platelet count, or serum albumin. From the 4th - 6th day of illness, prognostic indicators should be AST, ALT, albumin, or bilirubin total.
Use of a smartphone app to inform healthcare workers of hospital policy during a pandemic such as COVID-19: A mixed methods observational study
Authors: Helou R. I. , Waltmans–den Breejen C. M. , Severin J. A. , Hulscher M. E. J. L. , Verbon A. 
Published: January 2022

Objective
To evaluate the use of a COVID-19 app containing relevant information for healthcare workers (HCWs) in hospitals and to determine user experience.

Methods
A smartphone app (Firstline) was adapted to exclusively contain local COVID-19 policy documents and treatment protocols. This COVID-19 app was offered to all HCWs of a 900-bed tertiary care hospital. App use was evaluated with user analytics and user experience in an online questionnaire.

Results
A total number of 1168 HCWs subscribed to the COVID-19 app which was used 3903 times with an average of 1 minute and 20 seconds per session during a three-month period. The number of active users peaked in April 2020 with 1017 users. Users included medical specialists (22.3%), residents (16.5%), nurses (22.2%), management (6.2%) and other (26.5%). Information for HCWs such as when to test for SARS-CoV-2 (1214), latest updates (1181), the COVID-19 telephone list (418) and the SARS-CoV-2 / COVID-19 guideline (280) were the most frequently accessed advice. Seventy-one users with a mean age of 46.1 years from 19 different departments completed the questionnaire. Respondents considered the COVID-19 app clear (54/59; 92%), easy-to-use (46/55; 84%), fast (46/52; 88%), useful (52/56; 93%), and had faith in the information (58/70; 83%). The COVID-19 app was used to quickly look up something (43/68; 63%), when no computer was available (15/68; 22%), look up / dial COVID-related phone numbers (15/68; 22%) or when walking from A to B (11/68; 16%). Few respondents felt app use cost time (5/68; 7%).

Conclusions
Our COVID-19 app proved to be a relatively simple yet innovative tool that was used by HCWs from all disciplines involved in taking care of COVID-19 patients. The up-to-date app was used for different topics and had high user satisfaction amongst questionnaire respondents. An app with local hospital policy could be an invaluable tool during a pandemic.
Immunogenicity and waning immunity from the oral cholera vaccine (Shanchol™) in adults residing in Lukanga Swamps of Zambia
Authors: Ng′ombe Harriet , Simuyandi Michelo , Mwaba John , Luchen Charlie Chaluma , Alabi Peter , Chilyabanyama Obvious Nchimunya , Mubanga Cynthia , Hatyoka Luiza Miyanda , Muchimba Mutinta , Bosomprah Samuel , Chilengi Roma , Kwenda Geoffrey , Chisenga Caroline Cleopatra 
Published: January 2022

Introduction
In cholera endemic areas, the periodicity of cholera outbreaks remains unpredictable, making it difficult to organize preventive efforts. Lack of data on duration of protection conferred by oral cholera vaccines further makes it difficult to determine when to deploy preemptive vaccination. We report on the immunogenicity and waning of immunity to Shanchol™ in Lukanga Swamps.

Methods
We enrolled a cohort of 223 participants aged between 18 and 65 years old from whom serum samples were collected at baseline, day 28 before administration of the second dose, and consecutively at 6, 12, 24, 30, 36, and 48 months. Vibriocidal antibody titres were measured and expressed as geometric mean titres. Box plots and 95% CI were computed at each visit for both Inaba and Ogawa. Seroconversion was defined as a four fold or greater increase in antibody titres compared to baseline titres.

Results
Overall, seroconversion against V. cholerae Inaba and Ogawa after 1st dose was 35/134 (26%) and 34/134 (25%) respectively. We observed a statistical difference in seroconversion between the two subgroups of baseline titres (low <80 and high ≥80) for both Inaba (p = 0.02) and Ogawa (p<0.0001). From a baseline of 13.58, anti-Ogawa GMT increased to 21.95 after the first dose, but rapidly waned to 14.52, 13.13, and 12.78 at months 6, 12 and 24 respectively, and then increased to 13.21, 18.67 and 23.65 at months 30, 36 and 48 respectively. A similar trend was observed for anti-Inaba GMT across the same time points.

Conclusion
We found that Shanchol™ was immunogenic in our study population and that vibriocidal antibodies may not be a good marker for long-term immunity. The observed rise in titres after 36 months suggests natural exposure, and this may be a critical time window opening for natural transmission in an endemic areas. We recommend re-vaccination at this time point in high risk areas.
Making doctors stay: Rethinking doctor retention policy in a contracted-out primary healthcare setting in urban Bangladesh
Authors: Bashar Farzana , Islam Rubana , Khan Shaan Muberra , Hossain Shahed , Sikder Adel A. S. , Yusuf Sifat Shahana , Adams Alayne M. 
Published: January 2022

Background
“Contracting Out” is a popular strategy to expand coverage and utilization of health services. Bangladesh began contracting out primary healthcare services to NGOs in urban areas through the Urban Primary Health Care Project (UPHCP) in 1998. Over the three phases of this project, retention of trained and skilled human resources, especially doctors, proved to be an intractable challenge. This paper highlights the issues influencing doctor’s retention both in managerial as well as service provision level in the contracted-out setting.

Methodology
In this qualitative study, 42 Key Informant Interviews were undertaken with individuals involved with UPHCP in various levels including relevant ministries, project personnel representing the City Corporations and municipalities, NGO managers and doctors. Verbatim transcripts were coded in ATLAS.ti and analyzed using the thematic analysis. Document review was done for data triangulation.

Results
The most cited problem was a low salary structure in contrast to public sector pay scale followed by a dearth of other financial incentives such as performance-based incentives, provident funds and gratuities. Lack of career ladder, for those in both managerial and service delivery roles, was also identified as a factor hindering staff retention. Other disincentives included inadequate opportunities for training to improve clinical skills, ineffective staffing arrangements, security issues during night shifts, abuse from community members in the context of critical patient management, and lack of job security after project completion.

Conclusions
An adequate, efficient and dedicated health workforce is a pre-requisite for quality service provision and patient utilization of these services. Improved career development opportunities, the provision of salaries and incentives, and a safer working environment are necessary actions to retain and motivate those serving in managerial and service delivery positions in contracting out arrangements.
Traquest Model
Authors: Rátai Dániel Balázs , Horváth Zoltán , Porkoláb Zoltán , Tóth Melinda 
Published: January 2022

Atomicity, consistency, isolation and durability are essential properties of many distributed systems. They are often abbreviated as the ACID properties. Ensuring ACID comes with a price: it requires extra computing and network capacity to ensure that the atomic operations are done perfectly, or they are rolled back.
When we have higher requirements on performance, we need to give up the ACID properties entirely or settle for eventual consistency. Since the ambiguity of the order of the events, such algorithms can get very complicated since they have to be prepared for any possible contingencies. Traquest model is an attempt for creating a general concurrency model that can bring the ACID properties without sacrificing a too significant amount of performance.
Kajian Etnobiologi Kelompok Etnik Dani: Bentuk Interaksi Masyarakat Dengan Taman Wisata Alam Gunung Meja, Manokwari, Papua Barat
Authors: Morip Tepinus , Krey Keliopas , Pattiselanno Freddy 
Published: January 2022

Selain sebagai penyedia air bersih, potensi flora dan fauna Taman Wisata Alam Gunung Meja (TWA Gunung Meja), sangat menjanjikan. Karena letaknya yang mudah diakses serta lokasinya yang berada di dalam kota Manokwari, interaksi yang terjadi antara masyarakat dengan kawasan ini juga sangat tinggi dan berdampak terhadap potensi keanekaragaman hayatinya. Penelitian ini bertujuan untuk mempelajari bentuk interaksi antara kelompok etnik Dani dengan TWA Gunung Meja serta merekam informasi etnobiologi mereka dan melakukan penilaian deskriptif dampak pemanfaatan terhadap kondisi lingkungan TWA Gunung Meja. Penelitian ini merupakan penelitian deskriptif dengan teknik observasi, wawancara dan studi kepustakaan dan semua hasil observasi dan wawancara yang diperoleh dalam penelitian ini dianalisis menggunakan statistik deskriptif. Pendekatan kontekstual digunakan untuk menjelaskan situasi di lapangan untuk melengkapi deskripsi lokasi penelitian. Hasil penelitian menunjukkan bahwa terdapat tujuh spesies tumbuhan dari enam famili dan enam spesies hewan dari enam famili dimanfaatkan oleh kelompok etnik Dani di kawasan TWA Gunung Meja. Tujuan pemanfaatannya bervariasi untuk kebutuhan sandang, pangan, energi dan pengobatan medis dan asesori budaya. Bagian tumbuhan yang dimanfaatkan berragam terdiri dari batang, ranting, dahan, daun, buah dan kulit, sedangkan daging, lemak, empedu, kulit, cakar dan taring adalah bagian tubuh hewan yang dimanfaatkan kelompok etnik Dani sesuai tujuan pemanfaatannya.ABSTRACTApart from being a provider of clean water, the potential of flora and fauna of the Gunung Meja Nature Tourism Park (TWA Gunung Meja) is very promising. Due to its easily accessible and its location within the city of Manokwari, the interaction that occurs between the community and this area is also very high and creates impact on its biodiversity potential. This study aims to study the form of interaction between the Dani ethnic group and TWA Gunung Meja as well as record their ethnobiological information. We conduct a descriptive assessment of the impact of utilization on the environmental conditions of TWA Gunung Meja. This research is a descriptive study with observation, interview and literature study techniques and all observations and interviews obtained in this study were analyzed using descriptive statistics. A contextual approach is used to explain the situation in the field to complete the description of the research location. The results showed that there were seven plant species from six families and six animal species from six families used by the Dani ethnic group in the TWA Gunung Meja area. The purpose of its use varies for the needs of clothing, food, energy and medical treatment and cultural accessories. The various parts of the plant used consist of stems, twigs, branches, leaves, fruit and skin, while meat, fat, gall, skin, claws and fangs are animal body parts used by the Dani ethnic group according to their intended use
Pengaruh Penggunaan Aplikasi Wellingbom 2.0 terhadap Kemampuan Suami Mendeteksi Dini Kehamilan Risiko Tinggi
Authors: Pratamaningtyas Susanti , Titisari Ira 
Published: January 2022

Background: The COVID-19 pandemic has a significant impact on the health sector. In Kediri, pregnant women have limited access to checking their conditions. Many high-risk pregnancies are happening, especially in the Sukorame area. It makes the family, especially the husband, should pay more attention to his wife’s pregnancy. However, husbands often have no idea about pregnancy, including how to detect early high-risk pregnancy conditions. It often leads to delays in handling this problem. This study aimed to determine the effect of using The Wellingbom 2.0 Application on husbands' ability to detect early high-risk pregnancies.Method: This study used a research and development design with a descriptive and quasi-experiment approach. The population was 100 people. Samples were 80 people using incidental sampling techniques with the inclusion criteria were husbands of pregnant women who live in the working area of Sukorame Health Center and have an android-based smartphone, also they must be able to operate it. The data that have been collected were conducted normality test and then tested using Wilcoxon match pair statistic test by SPSS 16.00. Respondents pretested and were given an application for one week, after which the posttest was done.Results: The result of the normality test showed p-values of 0.004 for pretest and 0.000 for posttest, this indicates abnormally distributed data. Further analyzed using non-parametric sample Wilcoxon 2-paired test showed p-value 0.000, which means Ha accepted. It showed a significant change in respondents' ability to perform early detection to high-risk pregnancy after using the wellingbom 2.0 application. It would be better if husbands were also being educated about high-risk pregnancies to increase their awareness of their wives’ pregnancies.
Prevalencia del déficit de vitamina D y su relación con la hormona paratiroidea
Authors: Ravelo Marrero Alejandro José , Guillén Carlos Antonio , Menacho Román Miriam , Rosillo Marta , Del Rey José Manuel , Gómez Ana , Terán María Andreína , Vázquez Mónica , Arribas Ignacio 
Published: January 2022

Resumen

Objetivos
Evaluamos la prevalencia del déficit de la 25-hidroxivitamina D (25-(OH)D) en nuestro entorno, en función de la estación del año, el sexo y la edad de los sujetos. Así mismo, analizamos su relación con los niveles de la hormona paratiroidea (PTH).

Métodos
La población de estudio estaba compuesta por pacientes con peticiones de análisis de 25-(OH)D entre el 1 de enero y el 31 de diciembre de 2018, registradas en la base de datos del sistema informático del laboratorio. Se excluyeron las muestras de pacientes pediátricos (<18 años), así como de aquellos sujetos con factores que pudieran afectar a los niveles de 25-(OH)D y/o PTH (e.g. insuficiencia renal, enfermedad hepática, trastornos de la PTH).

Resultados
En los 33.601 pacientes (24.028 mujeres y 9.573 hombres), la prevalencia del déficit de 25-(OH)D fue del 48%. Se observó una mayor prevalencia entre los hombres, frente a las mujeres (53% vs. 46%). Por grupos de edad, la prevalencia fue mayor en el cuartil 1 (Q1, 74–87 años) y menor en el cuartil 2 (Q2, 60–73 años). Por estación del año, este déficit fue mayor en primavera (diferencias no significativas con respecto al invierno) y menor en verano. La relación entre la 25-(OH)D y la PTH se evaluó en 9.368 personas. El análisis de regresión lineal mostró una asociación débil (coeficiente – 0,303). El análisis de regresión logística múltiple reveló una relación significativa entre el déficit de 25-(OH)D y niveles elevados de PTH (Odds ratio (OR), 1,63). Otros factores de riesgo asociados a mayores niveles de PTH fueron el sexo (OR, 1,27), la estación del año (invierno, OR 1,63, primavera OR 1,16) y la edad (cuartil 1, OR, 3).

Conclusiones
La prevalencia del déficit de 25-(OH)D variaba según el sexo, la edad y la estación del año. Además, la elevación de la PTH está principalmente relacionada con niveles bajos de 25-(OH)D, el género femenino, la estación y la edad.
Fused pyrrolo-pyridines and pyrrolo-(iso)quinoline as anticancer agents
Authors: Amariucai-Mantu Dorina , Antoci Vasilichia , Sardaru Monica Cornelia , Al Matarneh Cristina Maria , Mangalagiu Ionel , Danac Ramona 
Published: January 2022

Abstract
This work emphasizes the synthesis strategies and antiproliferative related properties of fused pyrrolo-pyridine (including indolizine and azaindoles) and pyrrolo-(iso)quinoline derivatives recently reported in literature.
The adjunct condition and the nature of adjuncts
Authors: Ernst Thomas 
Published: January 2022

AbstractThis paper proposes a Minimalist analysis of the Adjunct Condition. It shows that extraction from adverbial adjuncts is common, and it reviews and extends (Truswell, Robert. 2011.Events, phrases, and questions. Oxford: Oxford University Press analysis), which holds that extractions are grammatical when the adjunct and matrix predicates together constitute a macro-event. Syntactically, a UI feature (representing “unintegration”) on adjuncts must be active at either LF or PF; where it is active ill-formedness results. However, if a macro-event is possible, UI is inactivated at LF, allowing extraction; and though an active UI at PF normally causes ill-formedness, this is repairable by sluicing. This analysis improves on existing analyses by accounting for possible extractions, island repair by sluicing, and the basic conception of adjuncts as relatively unintegrated phrases.