bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel single-point mutation of NEFH and biallelic SACS mutation presenting as intermediate form Charcot-Marie-Tooth: A case report in Vietnam
Authors: Truong Anh Tuan , Luong Anh Thi Lan , Nguyen Linh Hai , Nguyen Huong Van , Nguyen Diep Ngoc , Nguyen Ngoc Thi Minh 
Published: November 2022

Background:
Charcot-Marie-Tooth disease (CMT) is among the most common group of inherited neuromuscular diseases. SACS mutations were demonstrated to cause autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). However, there have been few case reports regarding to NEFH and SACS gene mutation to CMT in Vietnamese patients, and the diagnosis of CMT and ARSACS in the clinical setting still overlapped.

Case Description:
We report two patients presenting with sensorimotor neuropathy without cerebellar ataxia, spasticity and other neurological features, being diagnosed with intermediate form CMT by electrophysiological and clinical examination and neuroimaging. By whole-exome sequencing panel of two affected members, and PCR Sanger on NEFH and SACS genes to confirm the presence of selected variants on their parents, we identified a novel missense variant NEFH c.1925C>T (inherited from the mother) in an autosomal dominant heterozygous state, and two recessive SACS variants (SACS c.13174C>T, causing missense variant, and SACS c.11343del, causing frameshift variant) (inherited one from the mother and another from the father) in these two patients. Clinical and electrophysiological findings on these patients did not match classical ARSACS. To the best of our knowledge, this is the first case report of two affected siblings diagnosed with CMT carrying both a novel NEFH variant and biallelic SACS variants.

Conclusion:
We concluded that this novel NEFH variant is likely benign, and biallelic SACS mutation (c.13174C>T and c.11343del) is likely pathogenic for intermediate form CMT. This study is also expected to emphasize the current knowledge of intermediate form CMT, ARSACS, and the phenotypic spectrum of NEFH-related and SACS-related disorders. We expect to give a new understanding of CMT; however, further research should be conducted to provide a more thorough knowledge of the pathogenesis of CMT in the future.
Infective spondylodiscitis in hemodialysis patients
Authors: Cassó-Troche Lloyd R. , Echavarría-Uceta Jesús Antonio , Quiñones-Robles Joan , Haché-Pagan Caran , Herrera Ironelis , Encarnación Johnson , Rosa Silvestre De la , Cruz Dolores Mejía De la , Rojas Limber , Vásquez Pedro Pablo Díaz 
Published: November 2022

Background:
Spondylodiscitis is a potentially catastrophic complication in patients on hemodialysis. It is slow and insidious onset and nonspecific symptoms have contributed to the late detection of this infectious process. Here, we reviewed the clinical characteristics and outcomes for patients on hemodialysis who developed spondylodiscitis who were diagnosed with spondylodiscitis.

Methods:
From 2011 to 2021, 11 (0.4%) of 2557 patients on hemodialysis were diagnosed with spondylodiscitis based on clinical symptoms, patients averaged 56.9 years of age, seven were male, and they presented with fever in just two cases. The most frequent comorbidities included hypertension (ten patients) and diabetes mellitus (seven patients). Here, we reviewed the clinical, radiological (i.e., MR scans), laboratory markers, and treatment choices (i.e., nonsurgical vs. surgical) for these 11 hemodialysis patients.

Results:
Ten of the 11 patients underwent spinal surgery, and five were later readmitted for recurrent of infections. There was just one nonsurgical mortality.

Conclusion:
For patients on hemodialysis, the new-onset of spinal pain may signal the onset of spondylodiscitis which should be rapidly diagnosed with MR studies and managed in a timely fashion either with antibiotic therapy and/or with surgery/antibiotics.
Review of anterior cervical diskectomy/fusion (ACDF) using different polyetheretherketone (PEEK) cages
Authors: Epstein Nancy E. , Agulnick Marc A. 
Published: November 2022

Background:
Multiple anterior cervical diskectomy/fusion (ACDF) techniques now use a variety of Polyehteretherketone (PEEK) cages; stand-alone (SA) and zero-profile (ZP) with/without screws, cages filled with demineralized bone matrix/autograft, and cages coated with hydroxyapatite or titanium. We compared the safety/ efficacy between different PEEK ACDF cage constructs in 17 studies, and in some cases, additionally contrasted results with “routine” ACDF (i.e. series/historical data performed with combinations of iliac autograft/allograft and plates).

Methods:
We focused on the clinical outcomes, fusion rates, postoperative radiographic changes/lordosis/ subsidence, and/or reoperation rates for various PEEK ACDF constructs vs. “routine” ACDF.

Results:
One to 3 and 4-level PEEK ACDF cages demonstrated high fusion rates, few cage failures, and low reoperation rates. Subsidence for PEEK ACDF cages did not reduce fusion rates or diminish the quality of postoperative outcomes. Further, titanium-coated (T-C) PEEK cages lowered fusion rates in one study (i.e. 44.1% fusions vs. 88.2% for routine PEEK ACDF) while ACDF PEEK cages coated with hydroxyapatite (HA) showed only a “trend” toward enhanced arthrodesis.

Conclusion:
One to 3-4 multilevel ACDF PEEK cage constructs demonstrated comparable safety/efficacy when compared with each other, or in select cases, with “routine” ACDF (i.e. using autograft/allograft and plates).
Engaging Pre-Clerkship and Clerkship Students as Medical Scribes in The Emergency Department
Authors: Aziz Rizk Abanoub , Al-Izzi Ahmed , Acharya Naitik , H Brown Liam , Rizq Gina , Gobraeil Samuel , J Soueid Hanifa 
Published: November 2022

The Emergency Department (ED) is a highly stressful and fast-paced environment in which doctors are challenged to efficiently adapt and recall knowledge to make safe patient-care decisions. A literature search was conducted to assess the evidence supporting the benefits of exclusively hiring pre-clerkship and clerkship medical students as medical scribes in the emergency department. Several databases were used to collect a total of (insert#) articles and studies to explore and summarize the benefits of its implementation. These include, but are not limited to, increasing medical student exposure to the specialty of emergency medicine, enhancing their clinical skills, and assisting students to pay-down their medical school-related debt. Furthermore, appointing medical students as scribes is mutually beneficial to the ED by helping to cut down the lengthy wait times for patients and reduce the significantly high rates of emergency physician burnout. We conclude that hiring medical students as scribes in the ED is a potentially beneficial practice that merits further consideration and analysis.
ẢNH HƯỞNG CỦA THỨC ĂN ĐẾN SINH TRƯỞNG VÀ PHÁT TRIỂN CỦA COPEPODA Apocyclops panamensis
Authors: Ngọc Trần Nguyên , Huy Nguyễn Văn 
Published: November 2022

Nghiên cứu này được thực hiện nhằm đánh giá ảnh hưởng của các công thức thức ăn (thức ăn tự chế, tảo khô Spirulina 80% và tảo tươi Chaetoceros sp.) đến sinh trưởng và phát triển copepoda Apocyclops panamensis phân lập từ ao nuôi tôm thẻ chân trắng trong thời gian 16 ngày. Kết quả cho thấy tốc độ tăng trưởng và phát triển của của copepoda Apocyclops panamensis khi cho ăn tảo tươi cao hơn so với khi cho ăn thức ăn tự chế và tảo khô (p < 0,05). Tỷ lệ mang trứng trung bình của copepoda trưởng thành ở nghiệm thức cho ăn tảo tươi là 18,41 và tự chế 16,95% cao hơn ở nghiệm thức tảo khô 13,21% (p < 0,05). Tuy nhiên, kích thước của copepoda khi cho ăn các loại thức ăn khác nhau không thấy có sự khác biệt (p > 0,05). Nghiên cứu này chỉ ra rằng, có thể nuôi sinh khối copepoda Apocyclops panamensis bằng thức ăn tự chế thay thế tảo tươi trong sản xuất giống thủy sản.
Rotavirus epidemiology and genotype distribution in hospitalised children, Greece, 2008 to 2020: A prospective multicentre study
Authors: Koukou Dimitra-Maria , Michos Athanasios , Chatzichristou Panagiota , Trimis Georgios , Tatsi Elizabeth-Barbara , Dellis Charilaos , Zachariadou Levantia , Liakopoulou Theodota , Chrousos George P , Syriopoulou Vasiliki ,   on behalf of Greek Rotavirus Study Group
Published: November 2022

Background
Two rotavirus (RV) vaccines were licensed in Greece in late 2006 and included in the national immunisation programme in 2012.

Aim
To study the epidemiology and genotype distribution of RV in children during the post-vaccination period and assess the impact of increased vaccination coverage.

Methods
In a prospective multicentre hospital-based study, hospitalised children (≤ 16 years) with an RV-positive faecal sample were recruited. Epidemiological and genotyping analyses were performed; periods of low (2008–12) and moderate (2012–20) RV vaccination coverage were compared. Statistical analysis was performed with a chi-squared or Mann–Whitney U test and logistic regression.

Results
A total of 3,874 children (55.6% male; n = 2,153) with median age of 1.4 years (IQR: 0.5–3.3) were studied during 2008–20. Most RV-infected children were aged ≤ 3 years (72.2%) and hospitalised during December–May (69.1%). Common RV genotypes (G1P[8], G2P[4], G3P[8], G4P[8], G9P[8], G12P[8]) were detected in 92.2% of samples; G-P combinations with prevalence above 1% were G4P[8] (44.1%), G1P[8] (25.4%), G2P[4] (14.9%), G9P[8] (3.5%), G12P[8] (2.2%), G3P[8] (2.1%), other (4.3%) and mixed (3.5%). Of all samples, 97.6% were homotypic or partially heterotypic to vaccines’ genotypes. With moderate vaccination coverage, the seasonal peak was detected earlier, children were older and partially or fully heterotypic genotypes were increased (p < 0.001).

Conclusions
In the era of moderate RV vaccination coverage in Greece, epidemiology of RV in hospitalised children seemed to change. However, most circulating genotypes remain homotypic or partially heterotypic to RV vaccines. Continuous epidemiological surveillance and genotyping are important to monitor possible changes arising from RV vaccines’ implementation.
¿Devociones opuestas?
Authors: Pecourt Juan , Obiol Sandra 
Published: November 2022

En este artículo, abordaremos la lógica específica de la precariedad cultural, incidiendo en los factores de género que sitúan a las mujeres que se dedican en posiciones de debilidad estructural. Se trata de un fenómeno complejo y multidimensional. En nuestro análisis nos hemos centrado en la relación entre trabajo creativo y trabajo de cuidados como espacios sociales diferenciados. Entendemos el “trabajo de cuidados” como la gestión del bienestar de las personas, imprescindible para la sostenibilidad de la vida y la reproducción de la fuerza de trabajo. Por otro lado, el “trabajo creativo” es la dimensión más visible de la actividad artística e implica la producción de obras que obtienen una valoración social y son reconocidas como artísticas. Incluye, sobre todo a raíz de los recientes los procesos de precarización, un importante componente de “trabajo gratuito”, el trabajo de fondo individual orientado a proveer las condiciones adecuadas para la creación y que hoy se centra en la construcción y mantenimiento de las redes sociales y de una e-reputación.
En definitiva, mientras que el trabajo creativo constituye la parte visible y socialmente reconocida de la práctica artística, el trabajo gratuito y el trabajo de cuidados forman la parte oculta, sin reconocimiento social, pero que determinan en gran medida los logros individuales, más allá de las concepciones románticas del “genio” centradas en el ámbito estrictamente creativo. En nuestro artículo reflexionamos acerca de la relación entre ambos trabajos, la construcción de sus lógicas constitutivas, generalmente incompatibles entre sí, e identificamos sus principales contradicciones.
Idiom berunsur nama organ tubuh manusia dalam tabloid bola (kajian materi pembelajaran ke-SD-an)
Authors: Anafiah Siti , Sudigdo Anang 
Published: November 2022

Tujuan penelitian ini adalah 1) untuk mengetahui bentuk kebahasaan idiom berunsur nama organ tubuh manusia dalam tabloid Bola. 2) Untuk mengetahui jenis-jenis idiom berunsur nama organ tubuh manusia yang terdapat dalam tabloid Bola. Desain penelitian ini adalah deskriptif. Subjek penelitian berupa idiom berunsur nama organ tubuh manusia yang terdapat dalam tabloid Bola yang terbit bulan Januari-Desember 2004. Objek penelitian ini adalah bentuk kebahasaan idiom dan jenis-jenis idiom berunsur nama organ tubuh manusia yang terdapat dalam tabloid Bola. Instrumen penelitian yang digunakan dalam penelitian ini adalah peneliti sendiri. Penelitian ini juga menggunakan alat bantu, yakni kartu data. Teknik pengumpulan data yang digunakan adalah teknik baca dan teknik catat. Metode dalam analisis data yang digunakan dalam penelitian ini adalah metode padan dan agih. Keabsahan data dilakukan melalui intrarater dan interater. Hasil penelitian menunjukkan bahwa pada tabloid Bola ditemukan gaya bahasa dari bentuk kebahasaan dan jenis idiom. Bentuk kebahasaan idiom berunsur organ tubuh manusia yakni kata dan frase. Dari jenis idiom dilihat dari segi keeratan unsur-unsurnya dalam membentuk makna, kandungan nilai, dan referensi unsur-unsur Idiom.
Kata kunci: Idiom, Organ Tubuh Manusia, Tabloid Bola
«Sola nel letto di me stessa»
Authors: Bottero Stefano 
Published: November 2022

L'articolo è approfondisce la poetica di Biancamaria Frabotta nella sua penultima raccolta poetica, La materia prima. Sebbene il panorama degli studi abbia prodotto più di un approfondimento sull’opera della poetessa, nessuno è stato ad oggi dedicato alla raccolta. Con lo scopo di produrre uno studio inedito sul lavoro poetico di Frabotta, lo scopo dell’articolo sarà operare un’analisi del corpus testuale con una metodologia critico-filosofica. Tale analisi sarà segmentata in tre paragrafi e approfondirà le questioni sollevate dalla centralità ontologica ed estetica della figura dell’animale, dalla concezione metafisica della poetessa e dalla componente teoretica compositiva. Il risultato dello studio fornirà una nuova lettura epistemologica della raccolta, utile per una più profonda comprensione, in senso lato, del lavoro di Frabotta. La letteratura critica sull’autrice sarà così arricchita da un contributo nuovo, sia nel senso della metodologia che del focus di ricerca.

English title: «Alone in the bed with myself». Observation of the last poetic conception of Biancamaria Frabotta
This essay focuses on the poetic conception of Biancamaria Frabotta in the collection La materia prima. The literature dedicated to Frabotta’s poetry is to date very wide. However, no studies on the collection have been produced to date. In order to offer an unprecedented insight into Frabotta’s poetic work, the purpose of this study is to perform a study of the textual corpus, approached through a philosophical critical methodology of analysis. Such analysis will be divided into three paragraphs and will focus on the issues raised by the ontological and aesthetical centrality of the figure of the animal, the metaphysical conception of the poet and the theoretical compositional component. The study will provide a new epistemological reading of the second-last poetry collection of Frabotta, which will also allow for a deeper understanding of her work. A new contribution will thus enrich the critical literature on the author both in the sense of the methodology and of the research focus.
Sistem Informasi Perpustakaan Berbasis Web SMAN 18 Jakarta Utara
Authors: Swastika Rahayu , Akhromi Ahmad , Mawanti Iis , Velany Mellamel 
Published: November 2022

Pada suatu sistem yang telah dirancang dan sudah diwujudkan dalam sebuah program sistem informasi pastinya akan berlanjut pada kegiatan implementasi pada sistem tersebut. Dengan demikian, teknologi informasi mengacu pada teknologi yang digunakan untuk menyimpan data. Dengan adanya kemajuan di segala bidang, segala macam cara untuk menyimpan data tersebut bisa dilakukan dengan komputer, atau yang biasa dikenal sebagai komputerisasi. Sistem informasi yang sedang penulis wujudkan adalah Sistem informasi informasi berbasis web, dalam sistem ini semua data dan aktifitas transaksi perpustakaan sudah terkomputerisasi. Proses implementasi sistem informasi berbasis web ini akan dilakukan pada SMAN 18 Jakarta Utara yang terletak di wilayah jakarta utara khususnya didaerah warakas. Karena pada fasilitas perpustakaan disekolah ini masih menggunakan sistem yang masih manual dengan hanya mencatat data peminjaman dan data buku hanya didalam sebuah buku transaksi dan hal tersebut menimbulkan adanya manipulasi data pada proses transaksi peminjaman dan pengembalian. Adapun metode yang saya gunakan dalam pengembangan perangkat, dengan menggunakan metode waterfall adalah: Analisis Kebutuhan Perangkat Lunak, Perancangan, Pembuatan Kode, Pengujian, dan Pendukung atau Pemeliharaan, sedangkan untuk teknik pengumpulan datanya adalah dengan mengamati proses transaksi perpustakaan di SMAN18, melakukan wawancara dengan perpustakaan. staf dan studi literatur. Setelah mengembangkan sistem informasi pelayanan perpustakaan di SMAN 18 Jakarta Utara, perpustakaan telah mengalami perbaikan dan perubahan sistem, menjadi lebih efektif dan efisien serta lebih kondusif, metode pengelolaannya menjadi lebih baik yaitu dari proses sistem manual menjadi terkomputerisasi. dan peningkatan keamanan data, serta sistem. Dengan pengelolaan ini, pengguna dapat mengakses melalui website dimanapun dan kapanpun untuk melihat transaksi yang sedang berlangsung dan melihat data buku perpustakaan.
Keberhasilan Manajemen Penjualan Lasser Work Service Zigzag di Semarang Menggunakan Java (Netbeans 7.3)
Authors: Harjunawati Sri , Addin Syahrial , Hendarsih Ida , Marthanti Amas Sari 
Published: November 2022

This research examines the success of Sales Information System Management at Zigzag Lasser Work Service, Semarang, Indonesia. The proposed system is a computerized information system where data can be managed and integrated properly and built with Java programming (Netbeans 7.3) based on localhost. With the proposed Sales Information System, it is able to produce fast, accurate and timely information to facilitate processing of product data, order data, payment data, delivery data or delivery of goods. Sales reports and income reports are generated automatically with integrated processing so as to produce reports that are accurate, fast and can be justified. The speed of data processing and minimizing the occurrence of human error can help management reduce costs in order to apply economic principles to achieve maximum profit.
Sistem Informasi Persediaan Barang pada Ahass Motocare Cikampek
Authors: Abdullah Tohir , Alfarizi Salman , Gunawan Deni , Basri Hasan , Mulyawan Alif Rizqi , Ichsan Nurul 
Published: November 2022

Persediaan mempunyai arti penting karena akan mempengaruhi tingkat produksi maupun penjualan, Tanpa adanya persediaan barang perusahaan tidak akan berjalan dengan lancar. Pada saat ini perusahaan perdagangan dihadapkan pada persaingan yang sangat ketat, maka dari itu perusahaan harus menyediakan layanan yang cepat dalam mengelola persediaan barang dagang. Sistem persediaan yang baik dapat membantu meningkatkan keuntungan perusahaan terutama dalam pelayanan jasa servis yang terdapat pada Ahass Motocare Cikampek ini. Jika persediaan barang dagangnya terpenuhi, maka kualitas pelayanan jas nya akan lebih meningkat dan akan lebih cepat dalam menangani permintaan konsumen. Proses pencatatan persediaan barang dagang pada Ahass Motocare Cikampek mengunakan pencatatan persediaan periodik, dimana hanya mencatat transaksi pembelian barang dagang saja dan harus dilakukan pengecekan fisik terhadap persediaan diakhir periode atau biasa kita sebut dengan istilah stock opname. Dalam proses pencatatan dan perhitungan yang ditetapkan oleh perusahaan masih menggunakan cara sederhana dengan ditulis diatas nota. Sehingga dalam pembuatan laporan keuangan nya sering terjadi hilang data karena nota yg digunakan sering hilang. Perlu dibuatkan sebuah sistem informasi Akuntansi dan penggunaan aplikasi guna menunjang kegiatan yang terjadi pada agar bisa dilaksanan dengan lebih cepat dan efisien. Dan pembuatan laporan keuangan nya bisa dilakukan dengan lebih cepat dan terhindar dari manipulasi data keuangan
THE USE OF MODERN EDUCATIONAL TECHNOLOGIES IN THE PROFESSIONAL ACTIVITIES OF PRIMARY SCHOOL TEACHER
Authors: Kostashchuk Oksana , Bilenkova Lidiia 
Published: November 2022

The article substantiates the importance and necessity of using modern educational technologies in the professional activity of a primary school teacher. The main task of modern education today is to create a comfortable educational environment for students, providing conditions that will promote the disclosure of cognitive activity and initiative of students. It is the active introduction of pedagogical technologies in the practice of school education that will allow to fully implement the outlined task. The teacher of the New Ukrainian School is a teacher of the new generation who is ready to apply modern educational technologies in his professional activity, which is an important component of the innovative competence of a teacher.Use of educational technologies in lessons will allow to form an active learner, successful in learning, able to make decisions independently, be responsible for their own actions and deeds. The primary school teacher must be familiar with the whole arsenal of educational technologies, understand the principles of educational technology, know interesting innovative methods and techniques of teaching and actively involve all participants in the educational process by using technology in educational activities.Emphasis is placed on the fact that the introduction of modern educational technologies in the professional activities of teachers opens access to the manufacturability of the educational process, access to information sources (information), makes the presentation of educational material at a high level by teachers and accessibility of students. The technologicalization of education is directly related to the use of modern educational technologies in lessons.Thus, educational technology is a way to ensure a successful educational system of socialization, personal and professional development of the individual, which can achieve this goal through the coordinated professional actions of teachers and all other participants in the educational process. Educational technology is a conceptual, systematic description of the actions of teachers and students, aimed at achieving the predicted results; it is a way of organizing and improving the educational process, etc.
Keywords: modern educational technologies; innovations; primary school teacher; leadership qualities of a teacher; innovative processes.