bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of oxidative degradation and calcification behavior of a silicone polycarbonate polyurethane‐polydimethylsiloxane material
Authors: Al Kayal Tamer , Losi Paola , Asaro Marianna , Volpi Silvia , Bonani Walter , Bonini Massimo , Soldani Giorgio 
Published: January 2022

AbstractThe biocompatibility and chemical stability of implantable devices are crucial for their long‐term success. CarboSil® is a silicon polycarbonate polyurethane copolymer with good biocompatibility and biostability properties. Here, we explored the possibility to improve these characteristics by introducing 30% of extra‐chain cross‐linkable poly(dimethyl siloxane) (PDMS). Patches made of CarboSil and CarboSil‐30% PDMS were manufactured by spray, phase‐inversion technique and subjected to a heating‐pressure treatment. Both materials showed good biocompatibility, either in viability and proliferation of cell‐based experiments both with mouse fibroblasts and subcutaneous implant in rats. Fourier‐transform infrared spectroscopy showed a significant decrease in soft segment loss in CarboSil‐30% PDMS samples with respect to CarboSil in in vitro accelerated oxidative treatments with CoCl2 and 20% H2O2 at 37°C up to 36 days. Same results were observed in subcutaneous implants up to 90 days. Field‐emission scanning electron microscopy on samples exposed to calcification solutions during 80 days highlighted the presence of a homogeneous distribution of calcium deposition over the entire surface of CarboSil samples, while no calcium deposits were observed in CarboSil‐30% PDMS samples. Patches subjected to subcutaneous experiments showed no sign of calcification after 90 days, irrespectively of their composition. Thanks to the improved characteristics in terms of degradation and calcification the modified materials described in this work hold great promise for their use in the manufacture of cardiovascular devices.
Human papillomavirus genotype concordance between Anyplex II HPV28 and linear array HPV genotyping test in anogenital samples
Authors: Coutlée François , de Pokomandy Alexandra , Burchell Ann N. , El‐Zein Mariam , Mayrand Marie‐Hélène , Rodrigues‐Coutlée Sophie , Money Deborah , Comète Émilie , McClymont Elisabeth , Rouleau Danielle , Franco Eduardo L. 
Published: January 2022

AbstractAnyplex II HPV‐28 (HPV‐28) can detect individually 28 HPV genotypes. We assessed the agreement between linear array HPV genotyping (LA‐HPV) and HPV‐28 for detection of 27 HPV genotypes in 410 stored anogenital samples (75 anal samples, 335 physician‐collected cervical samples) collected over 5 years from 410 individuals (13 men, 397 women), including 202 HIV‐seropositive individuals. HPV DNA was detected in 393 (95.9%, 95% confidence interval [CI]: 93.4–97.4) and 382 (93.2%, 95% CI: 90.3–95.3) samples with HPV‐28 and LA‐HPV (p = 0.13), respectively, for a good agreement of 96.3% (κ = 0.65). Of the 10503 HPV typing results, 10195 (780 positive, 9577 negative) were concordant, for an agreement of 97.1% (95% CI: 96.7–97.4) and an excellent of κ = 0.82 (95% CI: 0.80–0.84). The mean type‐specific concordance for 27 genotypes was 97.0%, 95% CI: 95.8–98.5 (κ = 0.86 ± 0.07, 95% CI: 0.83–0.88). Excellent agreement was obtained individually for all high‐risk genotypes (κ = 0.81–0.97) and for most other genotypes except for types 42, 44, 54, 68, and 69. The mean number of types per sample in discordant samples detected with LA‐HPV (3.0, 95% CI: 2.7–3.4) was greater than in concordant samples (1.4, 95% CI: 1.3–1.5; p< 0.001). In conclusion, HPV‐28 compared favorably with LA‐HPV, but was more frequently positive for HPV42 and HPV68.
Taking from the dead: Grave disturbance of Sarmatian cemeteries in the Banat region
Authors: Pavlovic Tamara , Grumeza Lavinia , Roksandic Mirjana , Djuric Marija 
Published: January 2022

AbstractThe phenomenon of intensive grave disturbance of the Carpathian Basin graves in the Antiquity is especially associated with the Sarmatian cemeteries, dated to between the first and early fifth centuries CE. In this paper, this phenomenon was investigated in 20 cemeteries (179 graves) from the Banat region (East Serbia and West Romania). Analyses showed that more than half of the graves in the Banat were reopened, without any regional or inter‐site difference, as well as no sex or age preferences. Applying archeothanatological methodology to filed documentation and published reports, we were able to discern three patterns of grave disturbance: displacement of the elements of the upper body; disarticulation and dislodgement of the entire body, and haphazard removal of the body together with the content of the graves. Results showed that grave reopenings heavily damaged skeletal remains by shifting bones, throwing them on the ground surface due to grave shoveling, and leaving the graves reopened without backfilling with skeletal remains being exposed for a longer period, which is confirmed by the traces of subaerial weathering changes on skeletal material. Graves were reopened after the full skeletonization of the corpse, yet in some cases with funerary containers or clothing still present, meaning that graves were opened several years after the burial. Previous theories on Huns and Avars being perpetrators could be confirmed only for later cemeteries, while the earlier ones could be reopened by the Sarmatian contemporaries, local community, or even descendants. Archeological evidence of grave reopening confirmed grave robbery as the most likely motivation, while no special criteria in the selection of removed grave items were confirmed, probably in the turbulent period of Late Antiquity with intensive wars and raids happened in the Carpathian Basin.
(Dimesityl)boron Benzodithiophenes: Synthesis, Electrochemical, Photophysical and Theoretical Characterization
Authors: Menduti Luigi , Baldoli Clara , Arnaboldi Serena , Dreuw Andreas , Tahaoglu Duygu , Bossi Alberto , Licandro Emanuela 
Published: January 2022

AbstractTriarylboranes containing linear or angular benzodithiophene moieties and bearing one or two dimesitylboron units were synthesized. The electrochemical and optical features of these compounds were investigated by cyclic voltammetry, UV/Vis and fluorescence spectroscopy while DFT calculations were run to analyze the energetic landscape of these systems. For both linear and angular benzodithiophenes, symmetrical disubstitution leads to the highest photoluminescence yields. The linear benzodithiophene disubstituted with two dimesitylboron units proved to be the most interesting and promising molecule as an electron‐transport material for organic electronics owing to its LUMO energy level of −2.84 eV which is close to those of commonly used electron transport materials like bathocuproine or bathophenantroline.
Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer
Authors: Yamamoto Daisuke , Oshima Hiroko , Wang Dong , Takeda Haruna , Kita Kenji , Lei Xuelian , Nakayama Mizuho , Murakami Kazuhiro , Ohama Takashi , Takemura Hirofumi , Toyota Mutsumi , Suzuki Hiromu , Inaki Noriyuki , Oshima Masanobu 
Published: January 2022

AbstractLoss‐of‐function mutations in RNF43 induce activation of Wnt ligand‐dependent Wnt/β‐catenin signaling through stabilization of the Frizzled receptor, which is often found in microsatellite instability (MSI)‐type colorectal cancer (CRC) that develops from sessile serrated adenomas. However, the mechanism underlying how RNF43 mutations promote tumorigenesis remains poorly understood. In this study, we established nine human CRC‐derived organoids and found that three organoid lines carried RNF43 frameshift mutations associated with MSI‐high and BRAFV600E mutations, suggesting that these CRCs developed through the serrated pathway. RNF43 frameshift mutant organoids required both Wnt ligands and R‐spondin for proliferation, indicating that suppression of ZNRF3 and retained RNF43 function by R‐spondin are required to achieve an indispensable level of Wnt activation for tumorigenesis. However, active β‐catenin levels in RNF43‐mutant organoids were lower than those in APC two‐hit mutant CRC, suggesting a lower threshold for Wnt activation in CRC that developed through the serrated pathway. Interestingly, transplantation of RNF43‐mutant organoids with intestinal myofibroblasts accelerated the β‐catenin nuclear accumulation and proliferation of xenograft tumors, indicating a key role of stromal cells in the promotion of the malignant phenotype of RNF43‐mutant CRC cells. Sequencing of subcloned organoid cell‐expressed transcripts revealed that two organoid lines carried monoallelic RNF43 cis‐mutations, with two RNF43 frameshift mutations introduced in the same allele and the wild‐type RNF43 allele remaining, while the other organoid line carried two‐hit biallelic RNF43 trans‐mutations. These results suggest that heterozygous RNF43 frameshift mutations contribute to CRC development via the serrated pathway; however, a second‐hit RNF43 mutation may be advantageous in tumorigenesis compared with a single‐hit mutation through further activation of Wnt signaling. Finally, treatment with the PORCN inhibitor significantly suppressed RNF43‐mutant cell‐derived PDX tumor development. These results suggest a novel mechanism underlying RNF43 mutation‐associated CRC development and the therapeutic potential of Wnt ligand inhibition against RNF43‐mutant CRC. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Assessment of chitosan:gum tragacanth cryogels for tissue engineering applications
Authors: Demir Didem , Aşık Uğurlu Müge , Ceylan Seda , Sakım Burcu , Genç Rükan , Bölgen Nimet 
Published: January 2022

AbstractGum tragacanth is one of the most widely used natural gums in food, medicine, cosmetics and personal care products, and its use as polysaccharide‐based scaffolds in tissue engineering applications has attracted great attention in recent years. The fabrication of pure gum tragacanth as a scaffold poses many challenges because of the high viscosity, poor mechanical properties and repulsive interaction between the polyanions. To overcome these, facilitate the formation of scaffolds and improve their final properties, chitosan and gum tragacanth were used together as natural, biocompatible and biodegradable polysaccharides. The scaffolds based on chitosan and gum tragacanth were successfully fabricated through cryotropic gelation and were characterized using different chemical, morphological, mechanical and biocompatibility analyses. All cryogel scaffolds exhibited a porous structure with an average diameter of 96.56–30.21 μm, exhibiting high liquid absorption capacity, appropriate mechanical stability and controlled degradation behavior. According to the biocompatibility results, mouse embryonic fibroblast cells adhered well to the scaffolds and achieved high viability. The results are also discussed in the light of their potential usefulness as a scaffold for tissue engineering applications. © 2022 Society of Industrial Chemistry.
A novel deep learning‐based method for detection of weeds in vegetables
Authors: Jin Xiaojun , Sun Yanxia , Che Jun , Bagavathiannan Muthukumar , Yu Jialin , Chen Yong 
Published: January 2022

AbstractBACKGROUNDPrecision weed control in vegetable fields can substantially reduce the required weed control inputs. Rapid and accurate weed detection in vegetable fields is a challenging task due to the presence of a wide variety of weed species at various growth stages and densities. This paper presents a novel deep‐learning‐based method for weed detection that recognizes vegetable crops and classifies all other green objects as weeds.RESULTSThe optimal confidence threshold values for YOLO‐v3, CenterNet, and Faster R‐CNN were 0.4, 0.6, and 0.4/0.5, respectively. These deep‐learning models had average precision (AP) above 97% in the testing dataset. YOLO‐v3 was the most accurate model for detection of vegetables and yielded the highest score of 0.971, along with high precision and recall values of 0.971 and 0.970, respectively. The inference time of YOLO‐v3 was similar to CenterNet, but significantly shorter than that of Faster R‐CNN. Overall, YOLO‐v3 showed the highest accuracy and computational efficiency among the deep‐learning architectures evaluated in this study.CONCLUSIONThese results demonstrate that deep‐learning‐based methods can reliably detect weeds in vegetable crops. The proposed method avoids dealing with various weed species, and thus greatly reduces the overall complexity of weed detection in vegetable fields. Findings have implications for advancing site‐specific robotic weed control in vegetable crops.
Belief reliability evaluation with uncertain right censored time‐to‐failure data under small sample situation
Authors: Chen Wen‐Bin , Li Xiao‐Yang , Li Fang‐Rong , Kang Rui 
Published: January 2022

AbstractUncertain right censoring (URC) which describes the situation that the censoring settings of test units are unrelated to their failure time often occurs in practical life testing. Besides, in practical life testing, the small sample situation is also common since the test resources are usually limited, which brings epistemic uncertainties to reliability evaluations due to the lack of information. Under such situation, the large sample‐based probability theory is not appropriate anymore to conduct reliability evaluations. In this paper, the belief reliability evaluation is conducted with uncertain right censored time‐to‐failure (TTF) data under the small sample situation based on the belief reliability theory. Firstly, to deal with epistemic uncertainties, a truncated normal uncertainty distribution of lifetime is given, and the belief reliability evaluation is presented using the uncertain measure. Then, the corresponding uncertain statistics method for unknown parameter estimation is provided with objective measures. Finally, a simulation study and a practical case are used to illustrate the proposed method. The results show that the proposed method is suitable to deal with epistemic uncertainties and can achieve more accurate and stable mean time‐to‐failure (MTTF) results with uncertain right censoredTTFdata under the small sample situation compared to classical probability and Bayesian reliability methods.
Turning Away from Anti‐Blackness: A Critical Review of Adolescent Reading Motivation Research
Authors: Jones Sara 
Published: January 2022

AbstractResponding to calls for centering Black lives in our collective consciousness, this review uses Critical Race Theory to analyze researchers’ inclusion of race in conceptualizing and operationalizing adolescent reading motivation. Two questions guide this review: (1) How do researchers include race in theories of adolescent reading motivation? and (2) What assumptions do researchers make about race in studying adolescent reading motivation? What conclusions do they draw based on these assumptions? Through a systematic search, articles addressing adolescent reading motivation’s conceptual/theoretical foundations, measurement, and study as it relates to reading behaviors and outcomes were identified and analyzed using deductive thematic analysis. Findings emerged across three categories: (1) color‐evasiveness, demonstrating reading motivation was not conceptualized with Black readers in mind, (2) modus operandi, showing business‐as‐usual approaches to studying reading motivation, and (3) difference and deficit, illustrating how researchers have positioned Black readers in comparison to their white counterparts. Recommendations are made for how adolescent reading motivation can be reimagined to center Black readers’ histories, experiences, and brilliance.
Mechanistic Study on the Impact of the Occurrence of Various Basic Mineral Species on Spontaneous Combustion Propensity of Alkali‐Rich Low‐Rank Coal
Authors: Lu Beibei , Li Shouyi , Zhao Di , Lin Xiongchao , Wang Yonggang 
Published: January 2022

AbstractSpontaneous combustion of low‐rank coal, especially alkali‐rich coal, is a key issue that determines the safety of storage and transportation. To understand the role of different forms of Alkali and alkaline earth metals (AAEMs) on coal spontaneous combustion, AAEMs in raw coal were sequentially eluted by water, ammonium acetate (NH4OAc) and hydrochloric acid (HCl) solution. The occurrence forms and mineralogical characteristics of AAEMs in raw coal and its derived coal samples were investigated. Further, the spontaneous combustion tendency of raw coal and derived coal samples was measured by programmed heating process and the chemical structure parameters were characterized by thermogravimetric analysis and differential scanning calorimetry (TGA‐DSC) and in situ infrared spectroscopy. The results show that demineralization mitigates the spontaneous combustion tendency by the increasing the ignition temperature, confirming the enhancement of inherent mineral on low‐temperature oxidation. In situ infrared spectroscopy results suggest that acid‐soluble and ion‐exchangeable AAEMs have greater catalytic impact on the oxidation reaction of coal than water‐soluble AAEMs. Specifically, the complete removal of AAEMs by acid‐washing treatment has the most obvious effect on the change of oxygen‐containing functional groups, which greatly reduces the generation rate of carboxylic acid, ester and anhydride groups during the low temperature oxidation. Moreover, calcium elements including ion‐exchangeable calcium and HCl‐soluble calcium can promote the oxidation capacity of coal at low‐temperature, which were verified by loaded coal samples.
Synthetic Mechanism of UiO‐66‐NH2/BiVO4/BiOBr Spherical and Lamellar Dual Z‐scheme Heterojunction and Efficient Photocatalytic Degradation of Tetracycline Under Visible Light
Authors: Wei Lihong , Shi Dongni , Qi Yuwen , Zhang Yao 
Published: January 2022

AbstractIn order to solve antibiotic pollution, it is necessary to design photocatalysts with high specific surface area and efficient electron transfer performance. In this study, we report that two‐dimensional (2D) BiVO4/BiOBr flakes were anchored on the smooth surface of UIO‐66‐NH2 using a two‐step solvothermal‐hydrothermal approach, which forms the dual Z‐scheme mechanism and has rich specific surface area (306.5 m2/g), uniform particle size (2.05 nm) and wide absorption spectrum (2.76 eV). It shows 89.56 % tetracycline (TC) degradation efficiency within 180 min under visible light illumination due to the excellent adsorption properties and ample active sites. This work provides an effective strategy for designing a novel ternary photocatalyst to the degradation of refractory organic pollutants.
Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review
Authors: Panda Jasmine , Raiguru Bishnu P. , Mishra Mitali , Mohapatra Seetaram , Nayak Sabita 
Published: January 2022

AbstractThis review focuses on providing comprehensive highlights of the recent synthetic pathways of imidazo[1,2‐a]pyridines, assisted through transition metal‐catalyzed reactions, multi‐component reactions, cyclization, condensation, microwave‐assisted reactions, heteroannular and photocatalytic reactions. Among the heterocyclic groups, imidazo[1,2‐a]pyridines are considered as privileged structures because of their occurrence in many natural products. In this review, we have summarized the recent advances in the synthesis of imidazo[1,2‐a]pyridines from 2016 to 2021 from various substrates. This review will provide new initiatives to the chemists towards the synthesis of imidazo[1,2‐a]pyridines and all frequent challenges associated with the reported methods.
Integration of Highly Luminescent Lead Halide Perovskite Nanocrystals on Transparent Lead Halide Nanowire Waveguides through Morphological Transformation and Spontaneous Growth in Water
Authors: Chen Tao , Wang Chong , Xing Xinxin , Qin Zhaojun , Qin Fan , Wang Yanan , Alam Md Kamrul , Hadjiev Viktor G. , Yang Guang , Ye Shuming , Yang Jie , Wang Rongfei , Yue Shuai , Zhang Di , Shang Zhongxia , Robles‐Hernandez Francisco C. , Calderon Hector A. , Wang Haiyan , Wang Zhiming , Bao Jiming 
Published: January 2022

AbstractThe integration of highly luminescent CsPbBr3 quantum dots on nanowire waveguides has enormous potential applications in nanophotonics, optical sensing, and quantum communications. On the other hand, CsPb2Br5 nanowires have also attracted a lot of attention due to their unique water stability and controversial luminescent property. Here, the growth of CsPbBr3 nanocrystals on CsPb2Br5 nanowires is reported first by simply immersing CsPbBr3 powder into pure water, CsPbBr3−γ Xγ (X = Cl, I) nanocrystals on CsPb2Br5−γ Xγ nanowires are then synthesized for tunable light sources. Systematic structure and morphology studies, including in situ monitoring, reveal that CsPbBr3 powder is first converted to CsPb2Br5 microplatelets in water, followed by morphological transformation from CsPb2Br5 microplatelets to nanowires, which is a kinetic dissolution–recrystallization process controlled by electrolytic dissociation and supersaturation of CsPb2Br5. CsPbBr3 nanocrystals are spontaneously formed on CsPb2Br5 nanowires when nanowires are collected from the aqueous solution. Raman spectroscopy, combined photoluminescence, and SEM imaging confirm that the bright emission originates from CsPbBr3−γ Xγ nanocrystals while CsPb2Br5−γ Xγ nanowires are transparent waveguides. The intimate integration of nanoscale light sources with a nanowire waveguide is demonstrated through the observation of the wave guiding of light from nanocrystals and Fabry–Perot interference modes of the nanowire cavity.
A Genetically Engineered, Chain Mail‐Like Nanostructured Protein Material with Increased Fatigue Resistance and Enhanced Self‐Healing
Authors: Domínguez‐Zotes Santos , Fuertes Miguel Angel , Rodríguez‐Huete Alicia , Valbuena Alejandro , Mateu Mauricio G 
Published: January 2022

AbstractProtein‐based nanostructured materials are being developed for many biomedical and nanotechnological applications. Despite their many desirable features, protein materials are highly susceptible to disruption by mechanical stress and fatigue. This study is aimed to increase fatigue resistance and enhance self‐healing of a natural protein‐based supramolecular nanomaterial through permanent genetic modification. The authors envisage the conversion of a model nanosheet, formed by a regular array of noncovalently bound human immunodeficiency virus capsid protein molecules, into a supramolecular “chain mail.” Rationally engineered mutations allow the formation of a regular network of disulfide bridges in the protein lattice. This network links each molecule in the lattice to each adjacent molecule through one covalent bond, analogous to the rivetting of interlinked iron rings in the chain mail of a medieval knight. The engineered protein nanosheet shows greatly increased thermostability and resistance to mechanical stress and fatigue in particular, as well as enhanced self‐healing, without undesirable stiffening compared to the original material. The results provide proof of concept for a genetic design to permanently increase fatigue resistance and enhance self‐healing of protein‐based nanostructured materials. They also provide insights into the molecular basis for fatigue of protein materials.