bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monocyte subsets along with their inflammatory cytokines in septic lung injury: anti-inflammatory effect of sulfotransferase homolog 2 receptors blockade
Authors: Wang Peng , Yang Shuqi , Li Changcheng , Ma Baohua , Yi Mengqiu , Chen Xiaobo , Yu Min 
Published: July 2022

Abstract
Monocytes which are phenotypically and functionally heterogeneous contribute to septic organ damage by producing various inflammatory cytokines. The interleukin (IL)-33/sulfotransferase homolog 2 (ST2) is closely related to sepsis. The regulation effect of ST2 receptors on monocytes is not fully understood. This study aims to detect changes of monocyte subsets during septic lung injury and elucidate the effect of ST2 receptors on monocytes. Dynamic changes of monocyte subsets from patients with septic lung injury and mice post cecal ligation and puncture (CLP) were monitored. ST2 receptors on mice monocytes and concentrations of IL-33, IL-1β, IL-12 and IL-27 from peripheral blood or culture supernatant were detected. The results showed a novel CD14lowCD16− subset monocytes from peripheral blood of sepsis patients dramatically increased. Mice blood levels of IL-33, IL-1β, IL-12 and IL-27 were much higher in the CLP 24h group. There was expression of ST2 receptors on mice monocytes. Monocytes’ production of pro-inflammatory cytokines IL-1β and IL-12 induced by lipopolysaccharide (LPS) and IL-33 reduced when the ST2 receptors blockade. Changes of monocyte subsets with expression of ST2 receptors might play a role during septic lung injury by modulating inflammatory cytokines secretion, which might be novel targets for lung protection during sepsis.
EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption
Authors: Song Xiaoting , Cheng Xu , Jin Xiangang , Ruan Shengyu , Xu Xianquan , Lu Feng , Wu Xinhui , Lu Fangying , Feng Mingxuan , Zhang Liwei , Ge Renshan , Chen Haixiao , Hong Zhenghua , Hong Dun 
Published: July 2022

Abstract
Lung adenocarcinoma is the most common and aggressive type of lung cancer with the highest incidence of bone metastasis. Epidermal growth factor‐like domain multiple 6 (EGFL6) is an exocrine protein, and the expression of EGFL6 is correlated with survival of patient with lung adenocarcinoma. However, the association between EGFL6 expression in lung adenocarcinoma and bone metastasis has not been investigated. In this study, we found that EGFL6 levels in lung adenocarcinoma tissues correlate with bone metastasis and TNM stages in surgical patients. In vitro, overexpression of EGFL6 in lung adenocarcinoma cells promoted their proliferation, migration, and invasion ability compared with control by enhancing EMT process and activating Wnt/β-catenin and PI3K/AKT/mTOR pathways. In the nude mouse model, overexpression of EGFL6 enhanced tumor growth and caused greater bone destruction. Moreover, the exocrine EGFL6 of human lung adenocarcinoma cells increased osteoclast differentiation of bone marrow mononuclear macrophages (BMMs) of mice via the NF-κB and c-Fos/NFATc1 signaling pathways. However, exocrine EGFL6 had no effect on osteoblast differentiation of bone marrow mesenchymal stem cells (BMSCs). In conclusion, high expression of EGFL6 in tumor tissue of lung adenocarcinomas is associated with bone metastasis in surgical patients. The underlying mechanism may be the increased metastatic properties of lung adenocarcinoma cells with high EGFL6 level and the enhanced osteoclast differentiation and bone resorption by exocrine EGFL6 from tumors. Therefore, EGFL6 is a potential therapeutic target for the treatment of bone metastasis from lung adenocarcinoma.
Developing a CPD model for Eswatini- A Participatory Action Research study.
Authors: Magwenya Rodney Hudson , Ross Andrew 
Published: July 2022

Abstract
Background
Continuing professional development (CPD) is a key aspect to fulfil a commitment to lifelong learning for professionals registered with the Medical and Dental Council, the intention being to promote the health of patients and develop clinical expertise. The absence of formal CPD requirements for practitioners in Eswatini has resulted in a move to introduce an accredited system.
Methods
The qualitative study followed a participatory action research (PAR) methodology using a cooperative inquiry group of 10 medical practitioners in Eswatini to investigate how the current CPD program could be improved and formalised. PAR entailed four stages; observation, reflection, planning and action, using a semi-structured format to explore the areas of concern.
Results
Reflecting on the current situation resulted in three ways to improve CPD being identified: (1) adopt a formal, compulsory CPD model; (2) recognise achievements by practitioners who endeavour to improve their skills/knowledge through Entrustable Professional Activities, and (3) ensure that CPD is relevant to the workplace by using Quality-Improvement CPD (QI-CPD) and reflective diaries. These would be done by involving local practitioners, using adult learning principles and ensuring continuous evaluation and improvement of the CPD model.
Conclusions
There was general agreement on the need for a formalised CPD system to improve skill levels and provide an open platform to enhance patient care in a resource constrained setting. The findings provided information that can be used to plan and action its implementation through engagement with the country’s doctors in various forums and through ongoing research.
Short Version of the Inventory of Parental Representations, a self- report for Attachment Assessment among Adolescents
Authors: Lamourette Marilou , Ligier Fabienne , Guillemin Francis , Epstein Jonathan 
Published: July 2022

Abstract
Background: The Inventory of Parental Representations (IPR), a self-administered questionnaire, was developed primarily to identify styles of attachment in adolescence. However, it did not present stable psychometric properties in the various American studies carried out. The aim of this study was to adapt the IPR in French and to provide a shorter version with improved psychometric properties and sound content.Methods: The cross-cultural adaptation and content validity were carried out based on qualitative analysis by an Expert Committee and 10 non-clinical adolescents. For the quantitative analyses a cohort of 535 adolescent volunteers was enrolled, corresponding to 1070 responses, and divided into two groups: development and validation. The study of the metric properties of the adapted version of the IPR was realized in the development group, a sample of 275 responses. In case of mediocre results in the Confirmatory Factor Analysis, the development of a new and reduced IPR structure was planned using a mixed method including Classical Test Theory and Rasch Modelling in the development group. Subsequently, the study of the psychometric properties of the short, adapted version was confirmed in an independent sample of 795 responses (validation group). Results: Out of 62 items translated, 13 needed adaptations. The analysis of their metric properties produced mediocre results. Content and psychometric property analyses generated two Short version of the IPR in the development group: a paternal scale for Fathers (Short IPRF) with 15 items and a maternal scale for Mothers (Short IPRM) with 16 items. The sound content and good psychometric properties were confirmed in the validation group (Short IPRF: Comparative Fit Index =0.987, Tucker-Lewis Index =0.982, Root Mean Square Error of Approximation =0.027; Short IPRM: Comparative Fit Index =0.953, Trucker-Lewis Index =0.927, Root Mean Square Error of Approximation =0.068). Using Rasch modelling, the attachment was correctly measured overall especially for insecure attachment. Conclusions: A step-by-step process involving led to the generation of two questionnaires: a paternal scale, the Short IPRF, and a maternal scale with the Short IPRM providing opportunities to use this self-questionnaire to assess attachment among adolescents. Further work will provide a solid rating for this new tool.
Grip strength asymmetry and Activities of daily living in middle-aged and elderly Chinese Relevance studies
Authors: Yue Yuexue , Jia Yuling , Wang Xiuhong 
Published: July 2022

Abstract
Objective To investigate the association between grip strength asymmetry and the ability to perform daily activities in middle-aged and elderly Chinese.Methods Baseline data (2011) and second follow-up data from the China Health and Aging Tracking Survey (CHARLS) included people aged 45 years or older in the study population. The survey included handgrip strength asymmetry, demographic, and health behaviour variables. Generalised estimating equationsanalysedd the longitudinal association between grip strength asymmetry and ADL.Results There were 8529 respondents at baseline, of which 4054 (47.53%) were male, and the mean age of the respondents was (58.64 ± 8.87) years, with the oldest being 101 years and the youngest 45 years. Seven thousand five hundred fifty-six cases (88.59%) with spouses and 5,078 patients (67.06%) of the respondents lived in rural areas. Regarding educational attainment, 72.24% of the respondents had primary school education or above. Table 2 presents the grip strength asymmetries of daily activity functioning. From baseline to the second follow-up visit, grip asymmetry increased from 40.46% to 41.76%, and the percentage of ADL impairment rose from 14.60% to 20.46%. Using a generalised estimating equation including baseline and second follow-up data to analyse the longitudinal relationship between grip asymmetry and ADL, the interaction term between grip asymmetry and time was statistically significant after accounting for all confounding variables, indicating that the association between grip asymmetry and ADL at baseline and second follow-up differed. After gender stratification, the interaction term for grip asymmetry and time to follow-up remained statistically significant in males and females, with a 1.22-fold increase in the odds of ADL impairment in those with grip asymmetry compared to those with grip asymmetry and a 1.30-fold increase in the odds of ADL impairment in males with grip asymmetry in the gender stratification at, a difference that was also significant in females (OR=1.17,p< 0.05). Regression results for covariates indicated that location of residence, literacy, alcohol consumption, falls, and gender was significantly associated with daily activity dysfunction. In contrast, literacy and smoking were not statistically significantly associated with ADL.Conclusion Older adults with grip asymmetry are at increased risk of ADL impairment; Grap asymmetry can be used as a valid screening tool for middle-aged and older Chinese adults to help identify those at higher risk of ADL impairment.
The feasibility of teleconsultations in unplanned primary care: a cross section intervention
Authors: Hertens Sarah , Mullen Chris Van der , Schoenmakers Birgitte 
Published: July 2022

Abstract
IntroductionSince 2000, an increasing misuse of emergency services in Belgium was noticed. In 2015, a multidisciplinary task-force designed a triage system. Trained operators and integrated triage protocols were installed in a call center for life-threatening and non-life-threatening care needs. MethodThis cross-sectional survey with intervention studied the feasibility of teleconsultations in unplanned care in a primary care setting. Medical doctors were present at the call center during the weekend and on public holidays in the period of 17 April 2021 to 21 November 2021. Their task was to call They called patients who had contacted the call center to perform a teleconsultation, without interfering with regular care. Results21 triage doctors participated in the study, they completed 59 surveys and conducted 551 teleconsultations. They perceived the quality of the consultations as good with an average score of 82.85 out of 100 on the sliding scale. The doctors gave an average score of 72.40 for the level of certainty for diagnosis and treatment. For 415 consultations, triage doctors judged that the consultation would gain certainty if followed by a physical examination. Video was mainly considered to be valuable in psychiatric problems, allergic reactions and skin problems. DiscussionThis study showed that teleconsultations are feasible in unplanned care. Videos add value in particular cases. Only few barriers are reported in terms of communication, technology and equipment.ConclusionTeleconsultations in unplanned primary care could be performed with a high quality and a sufficient level of certainty. The willingness to conduct teleconsultations in unplanned care is high. It would be useful in a future study to investigate the feasibility, obstacles and needs for implementation of video consultations as they may differ from teleconsultations.
Impact of Drought on Forest Cover Change in Yabelo Forest in Semi-arid Region of Ethiopia
Authors: Wolteji Bayisa Negasa , Gizawu Fayera , Gemeda Dessalegn Obsi 
Published: July 2022

Abstract
Drought is a key challenge of third world countries whose economies are based on agriculture. Also, lack of rainfall plays a major role in exacerbating climate change. Drought is resulting in a decline in vegetation greenness and plant mortality specifically in semi-arid region. In this study, satellite-based drought assessment was used to characterize drought, and its impact on forest in semi-arid region of Ethiopia. Drought severity and forest cover change were detected over the period between 2014, and 2022 using geographic information system and remote sensing techniques. Vegetation condition index (VCI) and normalized difference vegetation index (NDVI) are used to detect drought severity over the past decades. Results show that 2015, 2017, 2019and 2022 were the most drought years. The spatial forest covers is significantly decreased during severe drought years. Minimum dense forest was observed in 2017and 2019 over spatial extend of 0.80 ha and 124.6 ha, respectively during drought years. To evaluate how precipitation deficit affect forest function, simple linear regression is performed. Result of (R2=0.49 and P=0.05) indicate that, nearly 50% of forest greenness is influenced by precipitation deficit. This study suggested that remote sensing indices are very crucial to characterize drought pattern at small “scale” particularly in assessment of drought impact on forest resource.
Density Functional Calculations of the Sequential Adsorption of Hydrogen on Single Atom and Small Clusters of Pd and Pt Supported on Au(111)
Authors: Meléndez-Rivera Joshua , Santana Juan A. 
Published: July 2022

Abstract
We have used density functional theory calculations to study the sequential adsorption of hydrogen on Pd and Pt atomic site catalysts such as single atom alloy catalyst (SAAC), single atom catalyst (SAC), and single clusters catalyst (SCC) of on Au(111). The results show that Pd systems tend to have near-zero free energy of hydrogen adsorption (Δ𝐺𝐻𝑎𝑑𝑠≈0) under various coverage conditions of adsorbed hydrogen. In the case of Pt systems, Δ𝐺𝐻𝑎𝑑𝑠≈0 only at high coverage conditions of adsorbed hydrogen. Such differences come from the preference of hydrogen for high-coordination and low-coordination sites on Pd and Pt, respectively. The low coordination of hydrogen results in multiple adsorption sites with Δ𝐺𝐻𝑎𝑑𝑠≈0 in SCC of Pt/Au. These results can help understand the different catalytic properties of Pd/Au and Pt/Au.
Separation or Integration? Further Insights from a Study of Chemical Datasets on Ancient Bronze Drums from South and Southeast Guangxi, China
Authors: Lu Qiuyan , Li Yanxiang , Zou Guisen , Gong Shiyang 
Published: July 2022

Abstract
Bronze drums of Type Beiliu and Type Lingshan are very remarkable among the eight types of bronze drum in China for their distinct ethnic features and huge form, representing the highest level of the bronze industry of Guangxi from the Han to Tang Dynasty. A total of 12 samples from drums of Type Beiliu and 7 from Type Lingshan are investigated in this study, providing a method to further discuss on the provenance of ore sources, ethnics and correlations between them. The analysis results reveal that the above two types of bronze drums share some common features in alloying patterns, lead isotope ratios and trace elements, while differing from each other for their characters (e.g., the decorative traditions). A conclusion can be drawn from this study that even though the above two types of bronze drums belong to different local powers, widely exchanging and communicating existing over ‘the boundary’, integration, as well as separation or confrontation, is suggested as the main status in an ancient ethnic society.
An Improved ANN-based Power Prediction Algorithm for Multi-type Jobs on Heterogeneous Computing Server
Authors: Jing Chao , Li Jiaming 
Published: July 2022

Abstract
This paper exploits the advantage of Artificial Neural Network (ANN) to design and implement an improved algorithm of power prediction on heterogeneous computing server with various types of jobs.First, the impact of multi-type of jobs has been taken into account. We divide the jobs into four categories: CPU-intensive, memory-intensive, I/O-intensive and GPU-intensive. We collect the data trace from these jobs by a set of benchmarks.Then, based on the collected data trace, power prediction algorithm has been established, so that developing an improved ANN-based power prediction algorithm with CNN-BiLSTM neural network and attention mechanism.Last, the experiment has been conducted via real-world heterogeneous computing based platform.Compared with the traditional neural network based prediction algorithms and non-neural network based prediction algorithms, our proposed prediction algorithm has better performance in prediction accuracy on power consumption.
A rectilinear oscillation of two spheres in an unbounded viscous fluid under the influence of a magnetic field
Authors: El-Sapa Shreen , Albalawi Wedad 
Published: July 2022

Abstract
This study examines the unsteady creeping quiescent movement of two rigid spheres within an infinite Stokes fluid flow under the influence of a magnetic field. At the surfaces of rigid spherical particles, Stokes flow is allowed to no-slip. The particles vary in size and radii. A line connecting the centers of the rigid spherical particles moves at different speeds. The solutions are exposed at low Reynolds numbers. As a result of boundary collocation, the differential equations are semi-analytically derived. The drag coefficients estimate the interaction impacts between rigid spherical particles. The coefficients of unsteady drag are presented graphically and tabulated for various parameters. Additionally, it is noted that the Hartmann number and the frequency parameter have a significant effect. Known results in the literature have been used to examine the precision and convergence of our collocation technique.
Patellar instability caused bone loss in femoral trochlea is associated with activation of the JAK1/STAT3 signaling pathway
Authors: Ma Chen , Kou Wenguan , Cui Zhaoxia , Liu Wenfeng , Liu Changli , Wang Shengjie , Wang Fei 
Published: July 2022

Abstract
Introduction: Patellar instability (PI) is closely correlated with bone loss in the developmental femoral trochlea. However, the molecular mechanism of PI-induced bone loss is not precise. Methods: Four-week-old male C57BL/6 mice were randomly divided into two groups. Mice in the experimental group underwent surgery to induce patellar instability. Distal femurs were collected at 2 and 4 weeks after surgery. Micro-computed tomography and histological observations were conducted to investigate the morphology of the femoral trochlea and the change in bone mass. qPCR, western blot, and immunohistochemistry analyses were performed to evaluate the expression of JAK1 and STAT3 in the subchondral bone.Results: Subchondral bone loss in the femoral trochlea was observed beginning two weeks after surgery in the experimental group and deteriorated over time, with higher expression of JAK1, STAT3, and RANKL, and lower expression of OPG, which resulted in morphological changes in the femoral trochlea, such as a flatter trochlear groove and a larger sulcus angle.Conclusion: Patellar instability could induce subchondral bone loss in developmental femoral trochlea and result in trochlear dysplasia finally with the activation of the JAK1/STAT3 signaling pathway. This study gives insights into the mechanism of bone loss in developmental trochlear dysplasia.
Prokaryotic communities throughout the desiccation of the hypersaline Tirez lagoon, Spain: analog to evaporitic basins on Mars?
Authors: Sanz Jose L. , Rodríguez Nuria , Sánchez-García Laura , Rojas Patricia , Uceda Esther , Carrizo Daniel , Amils Ricardo , Fairén Alberto 
Published: July 2022

Abstract
Tirez was a small and seasonal endorheic athalassohaline lagoon that was located in central Spain. In recent years, the lagoon has totally dried out, offering for the first time the opportunity to analyze its evolution to hyperaridity as an analog to similar processes in Meridiani Planum, Mars. In Meridiani, an early period of water ponding within enclosed basins evolved to a complete desiccation of the lagoons, leading to deposition of evaporitic sequences during the Noachian and well into the Hesperian. Here we describe (i) the microbial ecology of Tirez when the lagoon was still active 20 years ago, with prokaryotes adapted to extreme saline conditions; (ii) the composition of the microbial community in the dried lake sediments today, in many case groups that thrive in sediments of extreme environments; and (iii) the molecular and isotopic analysis of the lipid biomarkers that can be recovered from the sediments today. We discuss the implications of these results to better understanding the ecology of possible Martian microbial communities during the wet to dry transition at the end of the Hesperian, and how they may inform about research strategies to search for possible biomarkers in Mars after all the water was lost.
Luteolin alleviates inorganic mercury-induced liver injury in quails by resisting oxidative stress and promoting mercury ion excretion
Authors: Liu Yan , Guo Xinyu , Yu Lu , Huang Yuxiang , Guo Changming , Li Siyu , Yang Xu , Zhang Zhigang 
Published: July 2022

Abstract
I. Background: Inorganic mercury is a well-known toxic substance that can cause oxidative stress and liver damage. Luteolin (Lut) is a kind of natural antioxidant, which is widely found in plants. Therefore, we focused on exploring the alleviative effect of Lut on liver injury induced by mercuric chloride (HgCl2), and the potential molecular mechanism of eliminating mercury ions in quails. II. Methods and Results: Twenty-one-day-old male quails were randomly split into four groups: blank control group, Lut group, HgCl2 group, and HgCl2 + Lut group. The test period was 12 weeks. The results showed that Lut could significantly ameliorate oxidative stress, the release of inflammatory factors, and liver damage caused by HgCl2, and reduce the accumulation of Hg2+ in quail liver. Furthermore, Lut evidently increased the levels of protein kinase C α (PKCα), nuclear factor-erythroid-2-related factor 2 (Nrf2), and its downstream proteins, and inhibited nuclear factor-κB (NF-κB) production in the liver of quails treated by HgCl2. III. Conclusions: To sum up, our results suggest that Lut not only reduces the levels of oxidative stress and inflammation, but also promotes the excretion of Hg2+ by promoting the PKCα/Nrf2 signaling pathway to alleviate HgCl2-induced liver injury in quails.