bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tiny Baby Intubation Team Improves Endotracheal Intubation Success Rate but Decreases Residents’ Training Opportunities.
Authors: Gariépy-Assal Laurence , Janaillac Marie , Ethier Guillaume , Pennaforte Thomas , Lachance Christian , Barrington Keith , Moussa Ahmed 
Published: July 2022

Abstract
Objective: Assess the educational and clinical impact of a tiny baby intubation team (TBIT).Study Design: Retrospective study comparing endotracheal intubation (ETI) performed: pre-implementation of a TBIT (T1), six months post-implementation (T2), and four years post-implementation (T3).Results: Post-implementation of a TBIT, first attempt success rate in tiny babies increased (44% in T1 vs. 59% in T2; p=0.046) and the proportion of ETIs performed by residents decreased (53% in T1 vs. 37% in T2; p=0.002). After an educational quality improvement intervention (prioritizing non-tiny baby ETIs to residents, systematic simulation training and ETI using videolaryngoscopy), residents’ overall (63% in T2 vs. 79% in T3; p=0.03) and non-tiny baby ETI success rate improved (63% in T2 vs. 82% in T3; p=0.02).Conclusion: A TBIT improves success rate of ETIs in ELBW infants but decreases educational exposure of residents. Educational strategies helps maintain residents’ procedural exposure without impacting on quality of care.
Mixed sedimentary characteristics and genetic mechanism of Canglangpu Formation of the Lower Cambrian in the eastern Sichuan basin, SW China
Authors: Tong Zebin , Hu Zhonggui , Li Shilin , Huang Yufei , Zuo Yunan , Zhu Yixin , Pang Yulai , Dong Qingmin 
Published: July 2022

Abstract
The mixed sediments of the Canglangpu Formation in the Eastern Sichuan basin are widely developed and exhibit good exploration prospects. However, relevant research and understanding in this field are still insufficient. Further research on the mixed sediments of the Canglangpu Formation is of great significance to the exploration of mixed reservoirs in this area. During the depositional period of the Canglangpu Formation, the study area experienced two complete transgression-regression cycles, with obvious stratigraphic differentiation between the upper and lower parts. The lower part consists mainly of sedimentary carbonate diamictite, while the upper part is mainly composed of sedimentary clastic diamictite, distributed in the coastal-neritic shelf sedimentary environment. A model was established to identify the electrical response of the mixed sedimentary rocks in the study area based on the observations of typical outcrop profiles, identification of thin rock sections, and drilling and geological logging data. In addition, a diagram for the classification of mixed sediments suitable for the Canglangpu Formation was proposed by combining lithofacies characteristics with logging facies data. Mixed rocks in the study area can be divided into nine classes, namely sandstone, carbonate rocks, mudstone, carbonate sandstone, argillaceous sandstone, sandy carbonate rock, argillaceous carbonate rock, sandy mudstone, and Carbonate mudstone. The study area is dominated by mixed sedimentation with a typical facies-change. In fact, the sedimentary environment of the study area is a mixed coastal-detrital and shelf-carbonate sequence. In addition, two mixed sedimentary facies, five subfacies, and 12 microfacies were identified. The mixed sediments of the Canglangpu Formation, under the special background of alternating uplifts and depressions, show obvious characteristics of ring-like development around underwater paleo-heights. The main factors controlling the formation of mixed layers are vertical tectonic movements and sea-level changes.
Global perturbation of stratospheric water and aerosol burden by Hunga eruption
Authors: Khaykin Sergey , Podglajen Aurelien , Ploeger Felix , Grooß Jens Uwe , Tencé Florent , Bekki Slimane , Khlopenkov Konstantin , Bedka Kristopher , Rieger Landon , Baron Alexandre , Godin-Beekmann Sophie , Legras Bernard , Sellitto Pasquale , Sakai Tetsu , Barnes John , Uchino Osamu , Morino Isamu , Nagai Tomohiro , Wing Robin , Baumgarten Gerd , Gerding Michael , Duflot Valentin , Payen Guillaume , Jumelet Julien , Querel Richard , Liley Ben , Bourassa Adam , Hauchecorne Alain , Ravetta François , Clouser Benjamin , Feofilov Artem 
Published: July 2022

Abstract
The eruption of the submarine Hunga volcano in January 2022 was associated with a powerful blast that injected volcanic material to altitudes up to 58 km. From a combination of various types of satellite and ground-based observations supported by transport modeling, we show evidence for an unprecedented increase in the global stratospheric water mass by 13% as compared to climatological levels, and a 5-fold increase of stratospheric aerosol load, the highest in the last three decades. Owing to the extreme injection altitude, the volcanic plume has circumnavigated the Earth in only one week and dispersed nearly pole-to-pole in three months. The unique nature and magnitude of the global stratospheric perturbation by the Hunga eruption ranks it among the most remarkable climatic events in the modern observation era, with a range of potential persistent repercussions for stratospheric composition and climate.
Albarella's example to tackle climate change - a grain of hope
Authors: Zanella Augusto 
Published: July 2022

Abstract
We attempted to consider Albarella island as a model for estimating the ability of humans and the capacity of the environment to react to climate change. On its 550 hectares, this island hosts management centers, 2800 private homes, several restaurants and hotels, shops, public and private swimming pools, a golf course, beaches, green areas equipped to satisfy the 2,000 stable inhabitants and more than 110,000 annual tourists. We collected data on the following variables: 1) net storage of the semi-natural ecosystems; 2) diet of humans staying on the island; 3) fossil energy currently used to keep the island economically active; 4) electricity demand; 5) waste produced and 6) transportation. A dynamic simulation model of the island’s CO2 equivalent emissions proposes two scenarios that illustrate how these variables can change over the next 10 years if the management remains that of the present days, or switching to all photovoltaics, proposing new diets to inhabitants and tourists, planting trees on half of the island’s lawns. In the second case, CO2 eq emissions lowered to a level of 50 years ago (10 kt y-1). Taken to the level of planet Earth, the model nurtures a seed of hope.
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma
Authors: Zhang Zhi-Cheng , Liu Yi-Fu , Xi Ping , Nie Ye-Chen , Sun Ting , Gong Bin-Bin 
Published: July 2022

Abstract
Background: The response of advanced clear cell renal cell carcinoma (ccRCC) to immunotherapy is still not durable, suggesting that the immune landscape of ccRCC still needs to be refined, especially as some molecules that have synergistic effects with immune checkpoint genes need to be explored.Methods: The expression levels of CENPM and its relationship with clinicopathological features were explored using the ccRCC dataset from TCGA and GEO databases. Quantitative polymerase chain reaction (qPCR) analysis was performed to validate the expression of CENPM in renal cancer cell lines. ROC curves, Kaplan-Meier analysis, COX regression analysis and Nomogram construction were used to systematically evaluate the diagnostic and prognostic potential of CENPM in ccRCC. Besides, single gene correlation analysis, protein–protein interaction (PPI) network, genetic ontology (GO), kyoto encyclopedia of genes and genomes (KEGG) and gene set enrichment analysis (GSEA) were used to predict the biological behaviour of CENPM and the possible signalling pathways involved. Finally, a comprehensive analysis of the crosstalk between CENPM and immune features in the tumor microenvironment was performed based on the ssGSEA algorithm, the tumor immune dysfunction and exclusion (TIDE) algorithm, the TIMER2.0 database and the TISIDB database.Results: CENPM was significantly upregulated in ccRCC tissues and renal cancer cell lines and was closely associated with poor clinicopathological features and prognosis. Pathway enrichment analysis revealed that CENPM may be involved in the regulation of the cell cycle in ccRCC and may have some crosstalk with the immune microenvironment in tumors. The ssGSEA algorithm, CIBERSOPT algorithm suggests that CENPM is associated with suppressor immune cells in ccRCC such as regulatory T cells. The ssGSEA algorithm, CIBERSOPT algorithm suggests that CENPM is associated with suppressor immune cells in ccRCC such as regulatory T cells. Furthermore, the TISIDB database provides evidence that not only CENPM is positively associated with immune checkpoint genes such as CTLA4, PDCD1, LAG3, TIGIT, but also chemokines and receptors (such as CCL5, CXCL13, CXCR3, CXCR5) may be responsible for the malignant phenotype of CENPM in ccRCC. Meanwhile, predictions based on the TIDE algorithm support that patients with high CENPM expression have a worse response to immunotherapy.Conclusions: The upregulation of CENPM in ccRCC predicts a poor clinical outcome, and this malignant phenotype may be associated with its exacerbation of the immunosuppressive state in the tumor microenvironment.
Axillary Web Syndrome after Surgery for Breast Cancer
Authors: Chou Ya-Hui , Liao SuFen , Chen Dar-Ren , Chen Shou-Tung 
Published: July 2022

Abstract
Porpose The aims of this study were to identify (1) the incidence and risk factors for axillary web syndrome (AWS) 4 weeks after axillary lymph node dissection (ALND) for individuals with breast cancer (BC), and (2) whether early-intervention physical therapy (PT) could reduce the recurrence of AWS.Methods A retrospective review of patients with BC receiving ALND and patients with AWS referred to receive PT twice weekly between January 2019 and December 2020 was performed.Results A total 173 breast cancer patients receiving ALND were enrolled. The incidence of AWS was 18%, and the time to diagnosis was 26.3 days. There was a predominant difference in age (p=0.004), number of removed lymph nodes (p = 0.044), and whether they were receiving neoadjuvant chemotherapy (p =0.002) between patients with and without AWS. These 3 factors were associated with an increased risk of developing AWS. Initial shoulder flexion and abduction were 132.1˚ and 123.4˚, respectively. After 14.8 PT sessions, shoulder flexion and abduction improved to 172.3˚ and 171.8˚, respectively. Improvement in shoulder ROM was 40.2˚ and 48.4˚ in flexion and abduction, respectively, which was significant (p < 0.001).Conclusion Younger age, higher number of removed lymph nodes and receiving neoadjuvant chemotherapy were associated with an increased risk of developing AWS. Early intervention with a PT program could effectively restore shoulder function and decrease the incidence of AWS in long-term follow-up.
The Effect of Autoclave Aging with Different Surface Polishing Systems on the Surface Properties, Phase Transformation and Flexural Strength of Monolithic Zirconia
Authors: AKYILDIZ Gülşah , DUYMUŞ Zeynep YEŞİL 
Published: July 2022

Abstract
PURPOSE: This study was carried out to evaluate the effect of autoclave aging with different surface polishing systems on the surface properties, phase transformation and flexural strength of monolithic zirconia. MATERIALS AND METHODS: 48 disc-shaped specimens with a diameter of 15 mm and a thickness of 1.2 mm were prepared from monolithic zirconia block (Prettau Zirkonzahn). The specimens were randomly divided into 6 groups (n=8). The groups; control (only glazing), polished with Meisinger polishing kit and polished with OptraFine polishing kit. After the polishing, each group was divided into two and one of each group was aged in an autoclave. Surface roughness of specimens by profilometer device, surface microhardness by Vickers microhardness test, three-dimensional surface images by Atomic Force Microscope (AFM), surface properties by Scanning Electron Microscope (SEM), phase transformations by X-Ray Diffraction (XRD) were analyzed.Finally, the flexural strengths were evaluated. RESULTS: The effects of surface polishing applied on monolithic zirconia specimens on surface roughness, microhardness, flexural strength and phase transformation were found to be statistically significant (p<0.05). The highest surface roughness was detected in the group that applied the Meisinger polish kit. The effect of autoclave aging on the phase transformation was significant (p<0.05), but the effect on surface roughness, microhardness and flexural strength was not statistically significant (p>0.05). CONCLUSION: It was observed that the surface polishing systems applied to the monolithic zirconia specimens affected the surface properties, phase transformation and flexural strength. It was determined that the aging process in the autoclave did not affect the surface properties and flexural strength, but affected the phase transformation.
Research on analytical method of forming force of external spline cold roll-beating
Authors: Ma Qun 
Published: July 2022

Abstract
In order to determine the force and energy parameters of cold roll-beating of external spline, the characteristics of deformation zone in cold roll-beating are analyzed. The parameters and position of the deformation zone change with the movement of the Roller, the contact arc and the reduction are very small, and there is an incomplete deformation zone in the initial stage of cold roll-beating. An analytical method for calculating the unit pressure and deformation force is proposed. A cold roll-beating process is discretized into an infinite number of cold rolling processes with complex sections. The analytical formulas of unit pressure and deformation force in cold rolling are given, and the unit pressure value and its distribution characteristics are determined. In order to verify the analytical method, the finite element model of cold roll-beating is established and the forming force of cold roll-beating is calculated. The horizontal milling machine is modified to carry out the cold roll-beating experiment, and the cold roll-beating forming force was measured. The predicted results of the analytical formula are compared with the simulation and measured results. The results show that the maximum error of radial force is about 7% and 4% respectively, and the variation curve of radial force is basically consistent, but the time of one cold roll-beating process is slightly shorter. The analytical method correctly predicts the magnitude and change process of cold roll-beating forming force.
A Lightweight System for High-efficiency Edge-Cloud Collaborative Applications
Authors: Zhang Zhipeng , Ma Wenting , Li Hao , Tang Hongyi , Yuan Xiaohang , Hao Yuan , Xiao Jun , He Hongshun , Liu Wei , Zhou Zhiheng 
Published: July 2022

Abstract
With the development of IoT (Internet of Things) technology, ubiquitous IoT devices and the generated data increase the computational consumption dramatically. In industry, more and more manufacturers attempted to upgrade their manufacturing/assembly lines with sensors to achieve automated and intelligent workshops. Yet, to handle the massive and complicated data generated by end-point devices, technical companies started to utilize edge computing and artificial intelligence (AI). However, the shortcomings of AI in computing efficiency have become an obstacle when applying AI to edge devices. The majority of production systems need to run multiple applications for different detection tasks simultaneously. These tasks require edge nodes capable of managing threads/processes at the least cost to save computational consumption as much as possible. Thus, it is of great significance to improve the edge computing system whilst the presence of performance requirements and the limited computing resources. We intended to tackle the issues by focusing on optimizing the system structure and the complexity of the AI models. First and foremost, we proposed a distinctive cloud-edge collaborative framework composed of one universal block (UB) deployed on the edge devices and multiple parallel task-specific blocks (TSBs) on the cloud servers. This framework makes it possible to only deploy low-cost edge devices on the spots. To cooperate with the edge-cloud framework, we also introduced a pruning method that can reduce the model parameters without lowering the performance, making the system more efficient.
Screening and characterization of vaginal Lactobacillus strains as probiotic candidates
Authors: Zhu Chennuo , Huang Baoqi , Yu Changhao , Che Yuqing , Wu Dan , Wu Yue , Song Ping , Zhao Ye 
Published: July 2022

Abstract
Lactobacillus iners is often associated with increased risk of adverse gynecological and obstetric outcomes, such as vaginal dysbiosis and bacterial vaginosis (BV). Lactobacillus strains from the vagina of healthy women were screened for inhibitory activity against L. iners. Four active strains were identified, whereby L. gasseri H87 exhibited the highest inhibitory activity against L. iners, followed by L. rhamnosus H23. All four strains inhibited the growth of potential pathogens of the gastrointestinal, urogenital and reproductive tract, and were capable of co-aggregating with the cells of the tested pathogens to varying degrees. H23 and H78 exhibited survival rates above 80% under in vitro conditions simulating the vaginal, gastric and intestinal environment. The four strains showed good auto-aggregation of more than 30%. H23 and H87 also exhibited good co-aggregation of more than 30% with Listeria monocytogenes and Escherichia coli. Safety assessment showed that the four strains had the usual antibiotic susceptibility profile and did not produce hemolysins. Considering that H87 exhibited a better performance as a probiotic, we investigated the antibacterial substance produced by H87, and identified a bacteriocin with a molecular weight of 6.5 kDa. Based on strain characteristics and beneficial properties, we confirmed its ability to prevent/treat vaginal dysbiosis and maintain a healthy vaginal ecosystem. Therefore, we believe that H87 is a promising candidate for human trials.
Ocular Surface Microbiome in Diabetes Mellitus
Authors: Suwajanakorn Orathai , Puangsricharern Vilavun , Kittipibul Thanachaporn , Chatsuwan Tanittha 
Published: July 2022

Abstract
This cross-sectional, age-gender matched study included 20 eyes of non-diabetic subjects (non-DM group) and 60 eyes of type 2 diabetes mellitus (DM group). Subgroups of DM were classified by diabetic retinopathy (DR) staging into no DR (DM-no DR), non-proliferative DR (DM-NPDR), proliferative DR (DM-PDR), and by glycemic control (well-controlled DM; HbA1c<7%, poorly-controlled DM; HbA1c≥7%). Conjunctival swabs were performed for ocular surface microbiome analysis using conventional culture and next-generation sequencing analysis (NGS). A higher culture-positive rate was found in DM (15%) than in non-DM group (5%) (p-value=0.437). Pathogenic organisms and antibiotic-resistant strains were detected in the DR groups (DM-NPDR and DM-PDR). The NGS analysis showed that potentially pathogenic bacteria such as Enterobacteriaceae, Neisseriaceae, Escherichia-Shigella, and Pseudomonas predominated in DM, especially in DR. There was dissimilarity in the ocular surface microbiome between DM and non-DM groups. The subgroup analysis showed that the DR group had significantly different microbial community from DM-no DR and non-DM groups (p-value<0.05). The microbial community in the poorly-controlled DM was also significantly different from well-controlled DM and non-DM groups (p<0.001). Using the NGS method, our study is the first to signify the importance of DR and glycemic control status, which affect the changes in the ocular surface microbiome.
Prolonged body weight gain, lifestyle changes and health-related quality of life in children during the COVID-19 pandemic lockdown: a long-term follow-up study
Authors: Azrak Maria , Fasano M. Victoria , Avico Ana , Sala Marisa , Casado Carla , Padula Marcela , Kruger Ana , Malpeli Agustina , Andreoli Maria 
Published: July 2022

Abstract
Background
further investigation is needed to define the long-term impact of pandemic lockdown in children.
Objectives
to examine changes in body mass index z-score (zBMI), lifestyle, Health-Related Quality of Life and proportion of overweight or obesity (OW/OB) in 6- to 9-year-old children in Argentina.
Methods
observational study with baseline measurements prior to lockdown and follow-up after eight months of strict restrictive measures (November 2020, first visit, n = 144) and after ten months of partial reopening (September 2021, second visit, n = 108). Anthropometric changes from baseline to first visit in lockdown group (LG) were compared with a historical control group (HCG, n = 134). Follow-up visits included anthropometric measures, lifestyle questionnaire and Pediatric Quality of Life Inventory.
Results
Change in zBMI was higher in LG [median, IQR: 0.46 (-0.00; 0.83)] vs HCG [median, IQR: 0.02 (-0.31; 0.27)]; p < 0.001, particularly in children with pre-existing OW/OB. In LG, zBMI was higher at first and second visit vs baseline (p < 0.001) and in second visit vs first visit for boys (p = 0.037) but not for girls. The proportion of children with OW/OB increased from baseline (43.5%) to first (56.5%) and second visit (58.3%) (p = 0.029). Unlike girls, the proportion of boys with OW/OB increased from baseline to first and second visit (p = 0.045). Change in zBMI was higher in children with less healthy habits (p < 0.001).
Conclusions
Weight gain was not reversed and continued to increase in boys when lockdown measurements were eased, although sedentary behaviors decreased and quality of life improved, indicating that the effects of pandemic lockdown are difficult to reverse.
Therapeutics of urticaria: results from a hospital-based multicenter study in China
Authors: Wang Xin , Li Lin-Feng , Shi Xiao-Dong , Shen Yi-Wei 
Published: July 2022

Abstract
Background: Therapeutics of urticaria in Chinese outpatients remain to be illustrated.Objectives: To investigate clinical treatment of outpatients with urticaria, and provide theoretical evidence for selection of medication regimens.Methods: In this hospital-based multicenter study, urticaria outpatients filled in a questionnaire at initial visit and were followed-up (once per week, for 4 weeks).Results: 1715 urticaria outpatients were recruited and 647 completed 4- week’s follow-up. Their total UAS7 was reduced (27.44 at baseline, 16.87 in 1 week, 12.39 in 2 weeks, 7.21 in 3 weeks, 4.2 in 4 weeks). 71.8% patients recovered from urticaria (therapy was highly effective in 11%, whereas effective in 14.2%). The second-generation H1 antihistamines (sgAHs) (at conventional dose) were the most commonly prescribed drugs, with ebastine, levocetirizine and olopatadine being the leading ones (41.1%, 36.2%, and 16%, respectively). Combinations of several antihistamines (649 cases, 37.8%) at conventional dose were far more common than a single drug at escalated dose (59 cases, 3.4%). The combination of ebastine with levocetirizine was the most frequent options (18.25%, 313 cases), followed by combination of ebastine with compound glycyrrhizin (18.2%, 312 cases). The usage rates of tripterygium glycoside (19.6%), hydroxychloroquine (17.2%) and system application glucocorticoids (5.5%) in angioneurotic edema were much higher than in dermographic urticaria and chronic spontaneous urticaria. Conclusions: This study identifies curative therapy for Chinese outpatients with urticaria. The sgAHs, especially ebastine, are the most commonly prescribed drugs. Olopatadine has fast-acting and curative effects. Compound glycyrrhizin holds potential as a versatile collaborator.Combinations of several antihistamines at conventional dose is common.