bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chilblain-like lesions onset during SARS-CoV-2 infection in a COVID-19-vaccinated adolescent: Case report and review of literature
Authors: Paparella Roberto , Tarani Luigi , Properzi Enrico , Costantino Francesco , Saburri Chiara , Lucibello Roberta , Richetta Antonio , Spalice Alberto , Leonardi Lucia 
Published: May 2022

Abstract
Background: COVID toes or chilblain-like skin lesions have been widely reported during COVID-19 pandemic. Most cases were described in patients with negative microbiological tests for SARS-CoV-2, therefore the possible relationship with SARS-CoV-2 infection, as well as with the nowadays broadly available mRNA-based vaccination, has not been fully elucidated.Case presentation: We here describe the case of a 14-year-old male who developed chilblain-like skin eruptions during SARS-CoV-2 infection despite two mRNA-based vaccine doses and review the clinical and epidemiological characteristics of chilblain-like lesions as a cutaneous presentation of COVID-19 in children.Conclusions: Most children and adolescent with COVID toes have a mild or asymptomatic SARS-CoV-2 infection. Our report aims to highlight the possible onset of these skin lesions in vaccinated children, if infection has occurred, and the potential use of systemic corticosteroids as a first line treatment. Additional evidence is required to better understand SARS-CoV-2 infection and cutaneous manifestations in children and determine the relationship between chilblain-like lesions and COVID-19 vaccination.
Predefined-time stability for a class of dynamical systems and its application on the consensus control for nonlinear multi-agent systems
Authors: Guo Wanli , Wang Lu , Shi Lili , Sun Wen , Jahanshahi Hadi 
Published: May 2022

Abstract
This paper mainly focuses on the predefined-time stability for a class of fixed-time stable systems with the least upper bound of the settling time as an explicit parameter. It is mathematically proved that the considered systems can reach stability before any desired time rather than the overestimation of convergence time by previous fixed-time control methods. Furthermore, the comparison shows that our studied systems are more general, and many existing results can be derived. As an application of the exposed stability analysis, a predefined-time control algorithm is designed to study the average consensus problem for nonlinear leader-less multi-agent systems. Numerical simulations are always given to support our theoretical results. Keywords: Predefined-time stability; Fixed-time stable systems; Average consensus; Predefinedtime control algorithm; Multi-agent systems
Identification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse
Authors: Doherty Robert , MacLeod Brenna L. , Nelson Megan M. , Ibrahim Mostafa MH , Grande Beatriz de Carvalho Borges Del , Jaradat Nada , Finneran Matthew , Giger Roman , Corfas Gabriel 
Published: May 2022

Abstract
Like all receptor tyrosine kinases (RTKs), ErbB4 signals through a canonical signaling involving phosphorylation cascades. However, ErbB4 can also signal through a non-canonical mechanism whereby the intracellular domain is released into the cytoplasm by regulated intermembrane proteolysis (RIP) and translocates to the nucleus where it regulates transcription. These different signaling mechanisms depend on the generation of alternative spliced isoforms, a RIP cleavable ErbB4-JMa and an uncleavable ErbB4-JMb. Non-canonical signaling by ErbB4-JMa has been implicated in the regulation of brain, heart, mammary gland, lung, and immune cell development. However, most studies on non-canonical ErbB4 signaling have been performed in vitro due to the lack of an adequate mouse model. We created an ErbB4-JMa specific knock out mouse and demonstrate that RIP-dependent, non-canonical signaling by ErbB4-JMa is required for the regulation of GFAP expression during cortical development. We also show that ErbB4-JMa signaling is not required for the development of the heart, mammary glands, sensory ganglia. Furthermore, we identify genes whose expression during cortical development is regulated by ErbB4, and show that the expression of two of them, CRYM and DBi, depend on ErbB4-JMa. Thus, we provide the first animal model to study the roles of non-canonical RTK in vivo.
Urban Drainage Decision Model for Storm Emergency Management Based on Multi-objective Optimization
Authors: Bao Shitai , Lai Zehui , Chen Biao , Chen Shunqing 
Published: May 2022

Abstract
Urban water-logging is a challenging environmental issue in most urban areas. Effective, process-oriented water-logging simulation and drainage optimization models have become imperative for urban storm water and emergency management. This research provides a solution to urban water-logging through integrating water-logging prediction and drainage optimization schemes based on theories of cellular automaton and multi-objective optimization. An urban water-logging model for uncertain flow is constructed by using cellular automaton and rules in consideration of urban surface fragmentation and space complexity instead of definite mathematical equations. For dynamic simulation, outputs of water depth and flooded areas are projected with inputs of rainfall, soil infiltration, plant interception, gully discharge, and outflow to its neighbors in each cell, at any moment. The drainage decision model for optimal solutions is designed to calculate the maximal amount of water to be pumped from flooded zones to candidate reservoirs with minimal energy cost by using a multi-objective optimization approach. This integrated approach was successfully applied in the DongHaoChong catchment (11 km2) watershed, a central urban area of Guangzhou, southern China, to forecast urban water-logging and optimize drainage decision-making. The results shows that the simulation model in this study is reliable as a whole and is capable of simulating uncertain flow at any position at any moment with minimal data input and parameters in an urban environment. An integrated solution to urban water-logging prediction and drainage optimization can optimize decision-making to alleviate urban water-logging.
Lactobacilli displacement and Candida albicans inhibition on initial adhesion assays: A probiotic analysis
Authors: Rodríguez-Arias Robert Josue , Guachi-Álvarez Bryan Omar , Montalvo-Vivero Dominique Esther , Machado António 
Published: May 2022

Abstract
Objective
This study evaluates the probiotic activity of three vaginal Lactobacillus gasseri (H59.2, IMAUFB014, and JCM1131) and one non-vaginal L. plantarum ATCC14917 against three Candida albicans (ATCC10231, candidiasis, and healthy vaginal microbiota). Displacement of lactobacilli and adhesion inhibition of C. albicans were evaluated on an abiotic surface through adhesion assays with different experimental settings (ES) through low (1.0E + 03 CFU/ml) and high (1.00E + 09 CFU/ml) levels of colonization. ES simulated dysbiosis (ES1 and ES4), candidiasis (ES2), and healthy vaginal microbiota (ES3).
Results
At ES2 and ES3, L. gasseri H59.2 showed discrepant inhibition values among C. albicans isolates (ES2: P = 0.008, ES3: P = 0.030; two-way ANOVA). L. plantarum was only displaced by 23%, 31%, 54%, and 94% against low and high levels of C. albicans ATCC10231. L. plantarum was less displaced, when compared to L. gasseri strains (ES1: 61–84%, ES2: 82–96%, ES3: 83–95%, and ES4: 73–97%), showing multiple statistical differences (ES1: P = < 0.001, ES2: P = 0.003, and ES3: P = < 0.001; two‐way ANOVA). L. plantarum also showed a superior inhibition of C. albicans ATCC10231 in ES1 (81%) and ES2 (58%) when compared to L. gasseri strains (ES1: 27–73%, P < 0.001; and ES2:1–49%, P < 0.001; two‐way ANOVA).
Effect of groove configuration on mechanical properties and fracture behavior of 6061 Al alloy and CFRTP laser joint
Authors: Liu Xing , Wang Jianfeng , Bu Hengchang , Wang Feiyun , Zhan Xiaohong 
Published: May 2022

Abstract
Laser surface texturing is generally a promising approach to enhance the adhesion property of metal-thermoplastic hybrid structure, and the effect is related to the groove configuration. Laser joining of carbon fiber reinforced thermoplastic composite (CFRTP) to 6061 Al alloy under various groove configuration was carried out, aimed to investigate the effect of groove width and depth on interfacial morphology, mechanical properties and fracture behavior of CFRTP/ Al joints. The tensile-shear force was tested, and the fracture surface and interface morphology were observed by scanning electron microscopy. Besides, the numerical simulation of temperature field was conducted to reveal the joining mechanism. The results indicate that the tensile shear strength of CFRTP/ Al joint gradually increases with the increase of groove width and reaches the peak value of 22.8 MPa when the width is 0.5 mm, then it decreases as the groove width is further increased. Compared to groove width, the tensile shear strength of CFRTP/ Al joint presents similar variation trend with the increasing groove depth on Al alloy surface. When the groove depth reaches 0.6 mm, the maximum joint strength is 24.33MPa. After laser textured Al alloy, the surface fracture mode of CFRTP/Al laser joint features mixed fracture mode including cohesive fracture and interface fracture. This study provides a deeper understanding of the effect of groove configuration on the laser joining of CFRTP/ Al hybrid structure and potentially lays a foundation for the adjustment of suitable groove configuration toward obtaining the desired effect.
1-Aryl-1,2,3,4-tetrahydro-isoquinolines inhibit TNFR2-mediated proliferative expansion of CD4+Foxp3+ regulatory T cells
Authors: Chen Fengyang , Geng Chang-An , Zheng Jinbing , Li Tian-Ze , Yang Yang , Wang Yi-Fei , Li Ping , Jiang Meng-Meng , Li Yuan , Chen Ji-Jun , Chen Xin 
Published: May 2022

Abstract
Tumor-infiltrating CD4+Foxp3+ regulatory T (Treg) cells express high levels of TNFR2 which mediates TNF-induced proliferation and promotes tumor progression by suppressing anti-tumor immune responses. Therefore, the blockage of TNF-TNFR2 pathway represents a strategy to eliminate tumor-infiltrating Treg activity and leads to the recovery of host immune responses against tumor. In this study, screening of in-house small-molecule library resulted in the identification of 1-aryl-1,2,3,4-tetrahydro-isoquinolines as potent inhibitors of Treg proliferation mediated by TNF-TNFR2 signaling. Moreover, in-depth analysis of structure-activity relationship (SAR) revealed that the 6,7-dimethoxylation and 1-naphthyl substitution could improve the activity. Therefore, further investigation is warranted to evaluate if 1-aryl-1,2,3,4-tetrahydro-isoquinolines could be used as adjuvants to enhance cancer immunotherapy.
Menopause Rating Scale (MRS) in Bahasa Melayu language- Translation and Validation In Multiethnic Population In Malaysia
Authors: Mathialagan Sashimalar , Ramasamy Shamala , Nagandla Kavitha , Fern Siew Wei , Sreeramare Chandrashekhar T 
Published: May 2022

Abstract
Background
The menopause Rating Scale (MRS) is an internationally used tool to measure menopause-related symptoms to date and is unavailable in the Bahasa Melayu language. We aimed to translate and validate the Bahasa Melayu version of the MRS.
Methods
Translation of the English version of MRS into Bahasa Melayu was done by a bilingual expert and back-translated. Bahasa Melayu MRS was reviewed by a panel to determine the face validity. A total of 321 women aged 40–60 years residing in Klang, Selangor, Malaysia were selected by stratified random sampling method in a house-to-house survey. The Bahasa Melayu MRS was self-administered. Reliability analyses, including test-retest reliability (on 30 women after a two-week interval) were conducted. To ascertain the construct validity, 11 items were analyzed using exploratory factor analyses to determine the factor structure. To further support the psychometric study, confirmatory factor analysis was conducted to evaluate the structural model fit of Bahasa Melayu MRS.
Results
A total of 294 (91.6%) completed the survey and their mean age was 50.9 years (SD = 6.3). An overall Cronbach’s alpha for MRS was 0.904. Cronbach’s alpha for psychosomatic, urogenital, and Somatovegetative subscales were 0.889, 0.846, and 0.776 respectively. The corrected item correlations were approximately 0.6 and inter-item correlations were between 0.3 and 0.9. Assumptions for exploratory factor analyses were not violated; Kaiser–Meier–Olkin test revealed a value of 0.883 and Bartlett’s test value of sphericity was statistically significant (χ2 = 2400.483 and p < 0.001). EFA identified three factors accounting for 51.4% of the variance. This study encountered straddling of items. EFA yielded all 4 psychological items in Factor 2. The items which are supposedly falling into Somatic-Vegetative and Urogenital domains are straddled in Factor 1. Two items (heart complications and bladder problems) are grouped in the 3rd Factor. Nevertheless, confirmatory factor analyses showed a good model fit, fitting well into the theoretical constructs.
Conclusion
The translated English version of the Menopause Rating Scale into the Bahasa Version showed excellent reliability, test-retest reliability, and construct validity. The instrument can be used to assess menopause-related symptoms among Malaysian women.
Antenatal and perinatal healthcare delivery associations with Infant and Young Child Feeding (IYCF) breastfeeding practice in Nepal: a population-based cross-sectional study
Authors: Hollow Breanna Louise , Bulsara Max K. , Pant Prakash Dev , Wallace Hilary Jane 
Published: May 2022

Abstract
Background Infant and Young Child Feeding (IYCF) breastfeeding guidelines of the World Health Organization (WHO) have been promoted in Nepal since the early 1990s. This study investigated whether antenatal and perinatal healthcare delivery in Nepal were associated with breastfeeding within one hour of delivery and age-appropriate IYCF breastfeeding practice (exclusive breastfeeding to six months; continued breastfeeding to two years).Methods Data from the 2016 Nepal Demographic and Health Survey (NDHS) were analysed using multivariable logistic regression. The unit of analysis was an interviewed woman and her last-born child aged 0–23 months. Healthcare delivery components examined were four completed antenatal visits, place and type of delivery, infant-mother skin-to-skin contact post-delivery, and breastfeeding observation and counselling within two days post-delivery.Results Of 1938 mother-infant dyads, 1073 (55.4%) commenced breastfeeding within one hour of delivery and 1665 (85.9%) were engaged in age-appropriate breastfeeding. Breastfeeding within one hour of delivery was associated with infants delivered vaginally (aOR: 4.76, 95% CI: 2.96–7.65), mothers who were observed breastfeeding by a health professional (aOR: 1.58, 95% CI: 1.20–2.08) and early skin-to-skin contact (aOR:2.10, 95% CI: 1.63–2.72). Age-appropriate breastfeeding was lowest amongst those with children aged 4–5 months (40.8%) compared to women with infants aged 0–1 month (aOR: 0.158, 95% CI: 0.083–0.302). Antenatal and perinatal healthcare delivery were not significantly associated with age-appropriate breastfeeding.Conclusion Further promotion of early skin-to-skin contact and the observation of early breastfeeding practice, including after caesarean births, may increase early initiation of breastfeeding. Additional support, including postnatally, is necessary to increase exclusive breastfeeding of infants 4–5 months of age.
Lupane Derivatives: Design, Isolation, Synthesis and anti-malarial activity against Plasmodium falciparum 3D7 strains.
Authors: Yemback Pierre , Oben Eyong Kenneth , Efange Noella , Kamdem Michael HK , Ndinteh Dereck T , Odumosu Patricia O , Folefoc Gabriel N , Ayong Lawrence , Werner Thomas 
Published: May 2022

Abstract
To search for leads against malaria, compounds from the Cameroon Natural Product Library (CANAPL), were screened by molecular docking studies against the enzyme target Glyceraldehyde-3-phosphate dehydrogenase (PfGAPDH) for Plasmodium falciparum. Amongst these docking hits were the lupeol cinnamate (1) and oleanane cinnamate (2). Triterpenoids with structural similarities to (1) and (2) were isolated from Baillonella toxisperma (Pierre); olean-12-en-3β-hexadecanoate (3), 3-β-trans cinnamoyloxylup-20(29)-ene (4), oleanoic acid benzoate (5), 3β-amyrin (6), taraxerol (7), betulonic acid (8), β-sitosterol (9), betulinic acid (10), 3β-(trans-p-Coumaroyl)oxylup-20(29)-en-28-oïc acid (11), and screened alongside Betuline (12) and oleanolic acid (13). The favorable compounds 8 and 11 with 100% growth inhibition on Plasmodium falciparum 3D7 strains together with compounds 4, 10 and 12 were structurally optimized to afford new lupane derivatives with the privilege α-β unsaturated carbonyl medicinal scaffolds; betulonic acid acryl aldehyde (14), betulin acryl aldehyde (15), 3β-(trans-p-Coumaroyl)oxylup-20(29)-en-28-oïc acid acryl aldehyde (16), betulinic acid acryl aldehyde (18) and 3-β-trans cinnamoyloxylup-20(29)-ene acryl aldehyde (19) exhibiting more potent anti-malarial activities with IC50 values of 0.703 µM, 2.15 µM, 1.28 µM, and 3.79 µM for compounds 14, 15, 16 and 18 respectively. The modified compounds with the privilege α, β-unsaturated carbonyl medicinal scaffolds could be further optimized into potent antimalarial agents.
A practical “low-carbohydrate dietary care” model for elderly patients with type 2 diabetes
Authors: Feng Yuwei , Wang Qinyue , Hua Jiao , Liu Yiran , Zhong Xiaohui , Cao Hong , Xia Yanping , Zhang Feng 
Published: May 2022

Abstract
A randomized, double-blind, controlled experiment was conducted to observe how dietary care with restriction of carbohydrate absorption affects glucose and lipid metabolism in elderly patients with type 2 diabetes. Participants in the control group (Group C) were given standard treatment and in the experimental group (Group E) white common bean extract (WCBE) was given before meals. The trial was divided into two periods: intensive and maintenance intervention periods. Glucolipid metabolism was monitored in both groups during two intervention periods. Glycosylated hemoglobin (HbA1c) in Group E was lower than in Group C at the end of the 2- and 4-month, and significantly decline from baseline. The area under curve of oral glucose tolerance test (OGTT) glucose after 2- and 4-month intervention than baseline in Group E and were all significantly lower than in Group C after the intervention. Both High-density lipoprotein (HDL) and Low-density lipoprotein (LDL) also improved in group E (P < 0.05). In the clinical management of elderly patients with type 2 diabetes, this individualized model of care without restricting carbohydrate intake can effectively improve patients' glucose metabolism. The effect of this care model is similar to that of a low-carbohydrate diet care model. Therefore, this regimen could be a novel antidiabetic approach for patients with type 2 diabetes who are unwilling to restrict their carbohydrate intake.
ToxTree: Descriptor-based machine learning models to predict hERG and Nav1.5 cardiotoxicity
Authors: Arab Issar , Wonneberger Daniela , Barakat Khaled 
Published: May 2022

Abstract
Drug-mediated blockade of the voltage-gated potassium channel(hERG) and the voltage-gated sodium channel (Nav1.5) can lead to severe cardiovascular complications. This rising concern has been reflected in the drug development arena, as the frequent emergence of cardiotoxicity from many approved drugs led to either discontinuing their use or, in some cases, their withdrawal from the market. Here, we introduce two robust 2D descriptor-based QSAR predictive models for both hERG and Nav1.5 liability predictions. The machine learning models were trained for predicting the potency to each channel using multiclass classification at three different potency cut-offs (i.e. 1µM, 10µM, and 30µM). The ToxTree-hERG Classifier, a pipeline of Random Forest models, was trained on a large curated dataset of 8380 unique molecular compounds. Whereas ToxTree-Nav1.5 Classifier, a pipeline of kernelized SVM models, was trained on a large manually curated set of 1550 unique compounds retrieved from both ChEMBL and PubChem publicly available bioactivity databases. The hERG model yielded a multiclass accuracy of Q4 = 74.5% and a binary classification performance of Q2 = 93.2%, sensitivity = 98.7%, specificity = 75%, MCC = 80.3%, and a CCR = 86.8% on an external test set of N = 499 compounds. The proposed hERG inducer outperformed most metrics of the state-of-the-art published models and other existing tools. Additionally, we are introducing the first Nav1.5 liability predictive model achieving a Q4 = 74.9% and a binary classification of Q2 = 86.7% with MCC = 71.2% and F1 = 89.7% evaluated on an external test set of 173 unique compounds.
A Pan-Cancer Analysis of prognosis and immunity of cuproptosis-related gene FDX1
Authors: Ma Siyuan , Hu Die , Zhu Ping , Zhang Bochao , Zhang Yanzheng , Zhao Xiaoxiao , Pu Chun 
Published: May 2022

Abstract
Purpose FDX1 is a key gene regulating cuproptosis, but there is no pan-cancer analysis. We performed a pan-cancer analysis of FDX1 using bioinformatics techniques to derive the effect of FDX1 on the immune mechanisms and prognostic value of cancer patients.Methods We comprehensively investigated the expression profile of FDX1 using the Timer, TCGA, and GTEx databases, we established Cox proportional hazards regression models to evaluate the prognostic value of FDX1. cBioPortal database was used to study the frequency of changes and mutations of FDX1, the ULCAN database for FDX1 phosphorylation, sites, and using GSCA database to investigate the FDX1 DNA methylation in different cancers. The effect of FDX1 on immune mechanisms in various types of cancers was investigated. FDX1-related genes were collected using the gepia database, we performed GO enrichment and KEGG pathway analysis on FDX1 and FDX1-related genes, and single-gene GSEA pathway analysis was performed. We used String database to draw the Protein-Protein Interaction Networks of FDX1.Result FDX1 expression showed a significant downward trend in most tumors and was strongly associated with prognosis in some tumors. We observed elevated phosphorylation levels at the S177 site of KIRC or LUAD and decreased phosphorylation levels at the S159 and S177 sites of LIHC. There is a certain correlation between FDX1 DNA methylation and mRNA expression which related to the prognosis of the tumors. The proportion of immune cells in each tumor was essentially the same except for UVM. In LGG, KIRP and THCA, FDX1 expression was significantly correlated with immune infiltrating cells, it was significantly correlated with the levels of most immune-related genes. The correlation between FDX1 and TMB and MSI may provide a basis for drug use in certain tumors.Conclusion FDX1 can be used as a prognostic marker for some tumors.