bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calendar ageing modelling using machine learning: an experimental investigation on lithium ion battery chemistries
Authors: Celen Burak , Ozcelik Melik Bugra , Turgut Furkan Metin , Aras Cisel , Sivaraman Thyagesh , Kotak Yash , Geisbauer Christian , Schweiger Hans-Georg 
Published: August 2022

Background: The phenomenon of calendar ageing continues to have an impact on battery systems worldwide by causing them to have undesirable operation life and performance. Predicting the degradation in the capacity can identify whether this phenomenon is occurring for a cell and pave the way for placing mechanisms that can circumvent this behaviour. Methods: In this study, the machine learning algorithms, Extreme Gradient Boosting (XGBoost) and artificial neural network (ANN) have been used to predict the calendar ageing data belonging to six types of cell chemistries namely, Lithium Cobalt Oxide, Lithium Iron Phosphate, Lithium Manganese Oxide, Lithium Titanium Oxide, Nickle Cobalt Aluminum Oxide and Nickle Manganese Cobalt Oxide. Results: Prediction results with overall Mean Absolute Percentage Error of 0.0126 have been obtained for XGBoost algorithm. Among these results, Nickle Cobalt Aluminum Oxide and Nickle Manganese Cobalt Oxide type cell chemistries stand out with their mean absolute percentage errors of 0.0035 and 0.0057 respectively. Also, algorithm fitting performance is relatively better for these chemistries at 100% state of charge and 60°C temperature compared to ANN results. ANN algorithm predicts with mean absolute error of approximately 0.0472 overall and 0.0238 and 0.03825 for Nickle Cobalt Aluminum Oxide and Nickle Manganese Cobalt Oxide. The fitting performance of ANN for Nickle Manganese Cobalt Oxide at 100% state of charge and 60°C temperature is especially poor compared to XGBoost. Conclusions: For an electric vehicle battery calendar ageing prediction application, XGBoost can establish itself as the primary choice more easily compared to ANN. The reason is XGBoost’s error rates and fitting performance are more usable for such application especially for Nickel Cobalt Aluminum Oxide and Nickel Manganese Cobalt Oxide chemistries, which are amongst the most demanded cell chemistries for electric vehicle battery packs.
Perceptions about controlled human infection model (CHIM) studies among members of ethics committees of Indian medical institutions: A qualitative exploration
Authors: Sharma Abhishek , Apte Aditi , Rajappa Medha , Vaz Manjulika , Vaswani Vina , Goenka Shifalika , Malhotra Samir , Sangoram Rashmi , Lakshminarayanan Subitha , Jayaram Suganya , Mathaiyan Jayanthi , Farseena Khadeejath , Mukerjee Prarthna , Jaswal Surinder , Dongre Amol , Timms Olinda , Shafiq Nusrat , Aggarwal Rakesh , Kaur Manmeet , Juvekar Sanjay , Sekhar Amrita , Kang Gagandeep 
Published: August 2022

Introduction: Controlled Human Infection Model (CHIM) studies provide a unique platform for studying the pathophysiology of infectious diseases and accelerated testing of vaccines and drugs in controlled settings. However, ethical issues shroud them as the disease-causing pathogen is intentionally inoculated into healthy consenting volunteers, and effective treatment may or may not be available. We explored the perceptions of the members of institutional ethics committees (IECs) in India about CHIM studies. Methods: This qualitative exploratory study, conducted across seven sites in India, included 11 focused group discussions (FGD) and 31 in-depth interviews (IDI). A flexible approach was used with the aid of a topic guide. The data were thematically analyzed using grounded theory and an inductive approach. Emerging themes and sub-themes were analyzed, and major emergent themes were elucidated. Results: Seventy-two IEC members participated in the study including 21 basic medical scientists, 29 clinicians, 9 lay people, 6 legal experts and 7 social scientists. Three major themes emerged from this analysis—apprehensions about conduct of CHIM studies in India, a perceived need for CHIM studies in India and risk mitigation measures needed to protect research participants and minimize the associated risks. Conclusion: Development of a specific regulatory and ethical framework, training of research staff and ethics committee members, and ensuring specialized research infrastructure along with adequate community sensitization were considered essential before initiation of CHIM studies in India.
Clinical efficacy and neurobiological correlates of electroconvulsive therapy in patients with clozapine-resistant/intolerant schizophrenia: study protocol of multi-site parallel arm double-blind randomized sham-controlled study
Authors: Arumugham Shyam Sundar , Praharaj Samir K. , Shreekantiah Umesh , Sreeraj Vanteemar S. , Roy Chandramouli , Shenoy Sonia , Purohith Abhiram Narasimhan , Chithra Uppinkudru , Bagali Kiran Basawaraj , Venkataramaiah Sudhir , Nanjundaiah Gopala Krishna Kadarapura , Thennarasu Kandavel , Kumar Channaveerachari Naveen , Goyal Nishant , Das Basudeb , Mehta Urvakhsh Meherwan , Muralidharan Kesavan , Venkatasubramanian Ganesan , Sinha Preeti , Thirthalli Jagadisha 
Published: August 2022

Background: A substantial proportion of patients with treatment resistant schizophrenia do not respond well or partially to clozapine, with a subset that does not tolerate an adequate trial of clozapine. Electroconvulsive therapy (ECT) is regarded as one of the augmenting options, but there is a lack of high-quality evidence for this practice. This protocol describes a double-blind randomised sham-controlled modified-ECT trial to evaluate its efficacy in patients with clozapine resistant/intolerant schizophrenia. The study also involves multimodal investigations to identify the response predictors and the mechanistic basis of modified ECT in this population. Methods: One hundred consenting schizophrenia patients with resistance/intolerance to clozapine referred by clinicians for ECT would be randomly assigned to receive true ECT or sham ECT at three study centers. Sham ECT would mimic all the procedures of modified ECT including anaesthesia and muscle relaxation, except the electrical stimulation. After a blinded course, non-responders to sham ECT would be offered open-label true ECT. Clinical assessments, neurocognitive assessments and multimodal investigations (magnetic resonance imaging [MRI], electroencephalography, heart rate variability, investigative transcranial magnetic stimulation-transcranial direct current stimulation, gene polymorphism) would be conducted at baseline and repeated after the end of the trial, as well as open-label ECT course. The trial would evaluate the improvement in positive symptoms (scale for assessment of positive symptoms) of schizophrenia as the primary outcome measure with prediction of this change by resting-state functional-MRI based brain-connectivity as the second primary objective. Registration: Clinical Trial Registry of India (Reg no: CTRI/2021/05/033775) on 24th May 2021.
To Batch or Not to Batch? Impact of Admission Batching on Emergency Department Boarding Time and Physician Productivity
Authors: Feizi Arshya , Carson Anita , Jaeker Jillian Berry , Baker William Evan 
Published: August 2022

Trade-offs Caused by Batching Inpatient Admissions from Emergency Departments In “To Batch or Not to Batch? Impact of Admission Batching on Emergency Department Boarding Time and Physician Productivity,” Feizi and coauthors tackle the important problem of identifying causes of emergency department (ED) boarding with the goal of identifying a managerial lever to reduce it. They investigate the impact of batching admissions of ED patients. The authors empirically show that batching occurs frequently at the end of shifts when physicians wrap up their tasks. Interestingly, Feizi et al. find a trade-off. Batching improves individual physician productivity, which explains its prevalence. However, it increases boarding times, an outcome that negatively impacts patients and the hospital. A counterfactual analysis comparing empirical results to theoretical queuing models finds that eliminating batching reduces boarding times by 15%. The paper highlights that boarding can be reduced by physicians completing admissions work as it occurs rather than delaying to the end of shift.
355-nm direct-detection Doppler wind lidar for vertical atmospheric motion measurement
Authors: Ishii Shoken , Kishibuchi Kodai , Takenaka Hideki , Jin Yoshitaka , Nishizawa Tomoaki , Sugimoto Nobuo , Iwai Hironari , Aoki Makoto , Kawamura Seiji , Okamoto Hajime 
Published: August 2022

A compact and simple 355-nm direct-detection Doppler wind lidar (DDDWL) was developed to measure the line-of-sight (LOS) wind speed of the background atmosphere from atmospheric molecule return signals with and without aerosols and clouds. A receiver design with a Fabry–Perot etalon interferometer (FPEI) without an inside deposited step coating or fiber coupling is considered for the DDDWL using the double-edge technique. The receiver with the double-edge technique uses a FPEI and wedge prism to form a double-edge filter. The development of the double-edge filter in this combination is, to the best of our knowledge, an improvement at 355-nm wavelength. Considerations for the DDDWL receiver with a FPEI revealed that a full-angle light beam divergence into the FPEI and a working FPEI aperture are significant factors for the receiver design. Preliminary experimental evaluation demonstrated that the DDDWL had the potential of LOS wind speed measurements with a random error of less than 1 m/s when the signal-to-noise ratio was approximately 300. The DDDWL-measured vertical LOS wind speed profile was consistent with that of a 2-µm coherent Doppler wind lidar within the measurement error range. The preliminary experimental LOS wind measurement results demonstrated the capability of the DDDWL to measure low LOS wind speeds.
Brain signal predictions from multi-scale networks using a linearized framework
Authors: Hagen Espen , Magnusson Steinn H. , Ness Torbjørn V. , Halnes Geir , Babu Pooja N. , Linssen Charl , Morrison Abigail , Einevoll Gaute T. 
Published: August 2022

Simulations of neural activity at different levels of detail are ubiquitous in modern neurosciences, aiding the interpretation of experimental data and underlying neural mechanisms at the level of cells and circuits. Extracellular measurements of brain signals reflecting transmembrane currents throughout the neural tissue remain commonplace. The lower frequencies (≲ 300Hz) of measured signals generally stem from synaptic activity driven by recurrent interactions among neural populations and computational models should also incorporate accurate predictions of such signals. Due to limited computational resources, large-scale neuronal network models (≳ 106 neurons or so) often require reducing the level of biophysical detail and account mainly for times of action potentials (‘spikes’) or spike rates. Corresponding extracellular signal predictions have thus poorly accounted for their biophysical origin.
Here we propose a computational framework for predicting spatiotemporal filter kernels for such extracellular signals stemming from synaptic activity, accounting for the biophysics of neurons, populations, and recurrent connections. Signals are obtained by convolving population spike rates by appropriate kernels for each connection pathway and summing the contributions. Our main results are that kernels derived via linearized synapse and membrane dynamics, distributions of cells, conduction delay, and volume conductor model allow for accurately capturing the spatiotemporal dynamics of ground truth extracellular signals from conductance-based multicompartment neuron networks. One particular observation is that changes in the effective membrane time constants caused by persistent synapse activation must be accounted for.
The work also constitutes a major advance in computational efficiency of accurate, biophysics-based signal predictions from large-scale spike and rate-based neuron network models drastically reducing signal prediction times compared to biophysically detailed network models. This work also provides insight into how experimentally recorded low-frequency extracellular signals of neuronal activity may be approximately linearly dependent on spiking activity. A new software tool LFPykernels serves as a reference implementation of the framework.
Hyper-reflective retinal foci as possible in vivo imaging biomarker of microglia activation in von Hippel-Lindau disease
Authors: Pilotto Elisabetta , Torresin Tommaso , Bacelle Maria Laura , De Mojà Gilda , Ferrara Alfonso Massimiliano , Zovato Stefania , Midena Giulia , Midena Edoardo 
Published: August 2022

Purpose
von Hippel-Lindau (VHL) disease is caused by a mutation of the VHL gene and characterized by the development of retinal hemangioblastomas (RH). Current pathophysiologic mechanisms of RH development and progression are still insufficient to predict RH behavior. VHL gene is involved in the cellular response to hypoxia and in many intracellular signaling pathways expressed both in angiogenesis and inflammation. Optical coherence tomography (OCT) allows to identify hyper-reflective retinal foci (HRF) known as aggregates of activated microglial cells as possible in vivo biomarker of local inflammation. The aim of the present study was to investigate the presence of HRF in patients with genetically confirmed VHL disease.

Methods
In this cross-sectional study, patients with VHL underwent complete ophthalmological examination and OCT with HRA + OCT Spectralis. HRF were manually identified and calculated in inner (IR), outer (OR) and full retina. Age-matched healthy subjects were enrolled as controls.

Results
113 eyes of 63 VHL patients and 56 eyes of 28 healthy subjects were evaluated. HRF number was significantly higher in VHL than in controls in IR (28.06 ± 7.50 vs 25.25 ± 6.64, p = 0.042). No difference was observed in OR and in full retina (OR: 7.73 ± 2.59 vs 7.95 ± 2.51, p = 0.599; full retina: 35.79 ± 8.77 vs 33.20 ± 7.47, p = 0.093).

Conclusion
The increase of HRF, which mirror retinal microglial activation, characterizes VHL eyes. The role of activated microglia in the retina of VHL eyes needs to be better investigated, mainly considering local VHL disease manifestations.
Evaluation of trace calls by Xpert MTB/RIF ultra for clinical management in low TB burden settings
Authors: Amedeo Alberto , Beci Giacomo , Giglia Maddalena , Lombardi Giulia , Bisognin Francesco , Chiarucci Federico , Corsini Ilaria , Dal Monte Paola , Tadolini Marina 
Published: August 2022

BackgroundClinical interpretation of trace results by Xpert MTB/RIF Ultra assay (Ultra) used as an initial diagnostic test for tuberculosis (TB) may be challenging. The aim of the study was to evaluate the frequency and epidemiology of trace readouts in routine clinical practice in a low TB prevalence setting and to propose guidance on how to manage patients with trace calls considering the data available (clinical, radiological, bacteriological etc.).Materials and methodsA retrospective, observational, monocentric study was conducted at IRCCS Azienda Ospedaliero-Universitaria of Bologna, Italy between November 2017—December 2020. Presumptive TB patients with at least one Ultra trace result during diagnostic workup before treatment were included in the study. Patients with ongoing anti-TB treatment at the time of the trace call result or with no clinical data available were excluded from the study.ResultsFifty-nine presumptive TB patients with Ultra trace readouts were included in the study (mean age 37.0 years, 61% males). Four patients had a history of TB in the last 2 years. Twenty-five (42.4%) of the 59 samples with trace results were respiratory material. 57/59 (96.6%) patients started anti-TB treatment soon after obtaining trace results, based on clinical, radiological or other information available, while for two patients with a recent history of TB the trace result did not lead to anti-TB treatment. Culture was positive forM.tuberculosisfor 31/59 (52.5%) samples with trace calls: 13/25 (52.0%) were respiratory samples and 18/33 (54.5%) non-respiratory samples. The clinical and/or radiological findings of 47/57 (82.4%) patients given anti-TB therapy improved during treatment.ConclusionIn low TB incidence settings, Ultra trace calls in presumptive TB patients should be considered as true-positive and treatment should be started promptly, except in cases of recent history of TB, where careful evaluation of other diagnostic criteria is necessary before starting anti-TB treatment. A decisional algorithm for clinical management is proposed.
Dorothy Morland: Making ICA History, Anne Massey
Authors: Arya Rina 
Published: August 2022

Review of: Dorothy Morland: Making ICA History, Anne Massey
Liverpool: Liverpool University Press (2020), 216 pp.,
ISBN: 978-1-7896-2127-3, h/bk, £80.00, ISBN: 978-1-7896-2128-0, p/bk, £24.95
Método rápido y preciso para la cuantificación de busulfán en muestras de plasma mediante cromatografía líquida acoplada a espectrometría de masas en tándem (LC-MS/MS)
Authors: Villena-Ortiz Yolanda , Castellote-Bellés Laura , Martinez-Sanchez Luisa , Benítez-Carabante María I. , Miarons Marta , Vima-Bofarull Jaume , Barquin-DelPino Raquel , Paciucci Rosanna , Rodríguez-Frías Francisco , Ferrer-Costa Roser , Casis Ernesto , López-Hellín Joan 
Published: August 2022

Resumen

Objetivos
La administración de busulfán es ampliamente utilizada como parte del régimen de acondicionamiento en pacientes que se van a someter a trasplante de células madre hematopoyéticas. Se recomienda monitorizar las concentraciones plasmáticas de busulfán con el fin de optimizar la dosis en cada paciente y minimizar su toxicidad. El objetivo del presente estudio es validar un método analítico sencillo, rápido y costo-efectivo para la cuantificación de busulfán en plasma por cromatografía líquida acoplada a espectrometría de masas en tándem de aplicabilidad en la práctica clínica.

Métodos
Las muestras de plasma se prepararon aplicando un protocolo de un solo paso de precipitación de proteínas. A continuación, las muestras se analizaron mediante elución isocrática en una columna C18. La fase móvil está constituida por 2 mM de acetato de amonio y ácido fórmico al 0,1% disuelto a una proporción 30:70 de metanol/agua. Como patrón interno, se utilizó busulfán-D8.

Resultados
El tiempo total de medición se optimizó en 1,6 minutos. Las curvas de calibración fueron lineales entre 0,03 y 5 mg/L. El CV fue inferior al 8%. La exactitud de este método mostró un intervalo aceptable de entre 85 y 115%. No se observó interferencia por hemoglobina, lipemia o bilirrubina, ni siquiera a elevadas concentraciones de interferente. No se observó contaminación por arrastre ni efecto matriz al emplear este método. Se analizó el área bajo la curva de 15 pacientes pediátricos que recibieron tratamiento con busulfán previamente a un trasplante de células madre hematopoyéticas, y se estudió la correlación con las dosis administradas.

Conclusiones
El método fue validado exitosamente y demostró ser suficientemente sólido para la monitorización farmacoterapéutica en un contexto clínico.
Terahertz subwavelength sensing with bio-functionalized germanium fano-resonators
Authors: Chavarin Carlos Alvarado , Hardt Elena , Skibitzki Oliver , Voss Thomas , Eissa Mohammed , Spirito Davide , Capellini Giovanni , Baldassarre Leonetta , Flesch Julia , Piehler Jacob , You Changjiang , Grüssing Sönke , Römer Friedhard , Witzigmann Bernd 
Published: August 2022

Abstract
Localized Surface Plasmon Resonances (LSPR) based on highly doped semiconductors microstructures, such as antennas, can be engineered to exhibit resonant features at THz frequencies. In this work, we demonstrate plasmonic antennas with increased quality factor LSPRs from Fano coupling to dark modes. We also discuss the advances in the biofunctionalization of n-doped Ge antennas for specific protein immobilization and cell interfacing. Finally, albumin biolayers with a thickness of a few hundred nanometers are used to demonstrate the performance of the fano-coupled n-Ge antennas as sensors. A resonant change of over 10% in transmission, due to the presence of the biolayer, can be detected within a bandwidth of only 20 GHz.
Collaborative writing in an EFL secondary setting: the role of task complexity
Authors: Zhang Meixiu 
Published: August 2022

Abstract
Prior research found that compared with individual writing, collaborative writing improves learner performance and facilitates writing development. However, it remains unknown whether collaboration may allow learners to tackle writing tasks of varying cognitive demands. This study examined the role of task complexity in collaborative writing (CW) through (a) comparing how individual learners and dyads performed in tasks of varying cognitive demands and (b) examining how task complexity impacted pairs’ co-constructed texts. Sixty-nine Chinese junior high school learners of English (14–16 years old) were divided into two groups: individual writing (n = 21 learners) and a CW group (n = 24 pairs). Learners in both groups completed a simple and a complex task (manipulated via ± task structure). The written products were analyzed in terms of linguistic complexity, accuracy, fluency, and functional adequacy. Results indicated that the benefits of collaboration on learners’ written products were subject to the influence of task structure. When task structure is present, dyads produced functionally more adequate and longer texts than individual learners. In contrast, without task structure, dyads gained an edge over individual writers in terms of linguistic accuracy and fluency. Also, when examining the role of task complexity within the CW group, this study found that task structure exerted some influence on fluency, but not on other aspects of the jointly written products. Pedagogical and research implications were discussed.
Association between clinical variations and copy number variations in cases with Turner syndrome
Authors: Aksoy Ezgi , Cogulu Ozgur , Pariltay Erhan , Ozen Samim , Ata Aysun , Karaca Emin , Darcan Sukran 
Published: August 2022

Abstract

Objectives
Turner syndrome (TS) is one of the most common chromosomal abnormalities with an incidence of approximately one in 2,500 live births. Short stature and primary ovarian insufficiency are two most important characteristic findings of TS. Turner syndrome karyotypes include monosomy X, mosaic structure and X chromosome structural anomalies. Genotypic and phenotypic characteristics vary among cases. This study aimed to evaluate the clinical variations observed in TS cases with the copy number variations (CNV) detected by microarray study.

Methods
Fifty-three patients diagnosed with TS, between the ages of 0–18 were included in the study. Peripheral blood samples were taken from 36 cases for microarray study.

Results
Karyotypes were as follows: thirty-three of cases were 45,X, 7 were 45,X/46,XX, 6 were 45,X/46,Xi(Xq), 2 were 46,Xi(Xq), 2 were 45,X/46,r(X), 1 was 45,X/46,Xi(Xp), 1 was 45,X/46,XY and 1 was 45,X/46,X+mar(idicY) karyotype. A significant correlation was found between karyotype groups and FSH values of the cases (p=0.034). In monosomy X and mosaic isochromosome Xq cases, the FSH value was found to be significantly higher than those with 45,X/46,XX mosaic karyotype. CNVs were found in 8 (22.2%) out of 36 cases whose microarray study was performed. Unexpected atypical findings were discussed in the light of the characteristics of CNVs.

Conclusions
In conclusion, the microarray method has a great contribution in explaining many unexpected findings in TS cases. Moreover, those CNV findings may contribute for the explanation of the underlying mechanisms of those anomalies.