bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning the moisture stability of multiphase β‐Li3PS4 solid electrolyte materials
Authors: Lu Xin , Camara Osmane , Liu Zigeng , Windmüller Anna , Tsai Chih‐Long , Tempel Hermann , Yu Shicheng , Kungl Hans , Eichel Rüdiger‐A. 
Published: February 2022

AbstractEfficiently improving the moisture stability of β‐Li3PS4 materials could significantly reduce production costs and eventually enable the mass application. Nanoporous multiphase β‐Li3PS4 materials prepared via solvent‐assistant routes usually contain solvent or solvent decomposition segments associated with the amorphous Li3PS4 phase in their structures. Herein, the solvent ethyl propionate (EP) remains in the β‐Li3PS4 even after 220 h of annealing at 220°C. The possibility of tuning the moisture stability of β‐Li3PS4 by adjusting the content of the solvent is investigated by environmental scanning electron microscopy (ESEM) combined with other structural analysis techniques. The results demonstrated that the hydrogen‐containing amorphous Li3PS4 not only stabilizes the β‐phase at room temperature but also improves the moisture stability of the material. Although the rapid hydrolysis occurs on the surface of solvent‐containing β‐Li3PS4 materials under ambient conditions within 10 s, with 4 wt% EP content, the material can be exposed to 1.6% relative humidity (R.H.) for at least 8 h without any structural or microstructural change. Even with the lower amount of EP (1.2 wt%) in the Li3PS4 structure, the material can withstand 1% R.H. for more than 8 h, which allows the material to be manufactured in a dry room. Our observation proposes a simple method to slightly modify the moisture stability of β‐Li3PS4 to match the different manufacturing conditions.
An experimental and numerical investigation of the effects of the diaphragm pressure ratio and its position on a heated shock tube performance
Authors: Badri Yousif , Elbashir Aboubaker , Saker Ahmad , Ahmed Samer F. 
Published: February 2022

AbstractThe main purpose of this work was to investigate the performance of heated shock tube (ST) with different pressure ratios and diaphragm positions numerically and experimentally. The numerical model was developed to simulate the fluid flow inside a shock tube test facility located at Qatar University. The shock tube was a cast‐iron hollow tube with 6 m length, 50 mm internal diameter and 10 mm thickness. ST driver and driven sections were filled with helium–argon mixture and air. The driven section was heated up to 150°C using coils. At the middle of the ST, the diaphragm was made of aluminium sheet (0.5 mm) layers. Five different pressure ratios were implemented during the experiment, and performance evaluation depended on the strength of the incident shock Mach number. The inviscid numerical model solver used transient two‐dimensional time‐accurate Navier–Stokes CFD. The model introduced a parametric study regarding three different diaphragm positions (1m, 2m and 3m) and five pressure ratios (6–10) for each position. In addition to yielding the incident and reflected wave Mach number, reflected wave temperature was also considered a shock tube performance indicator. The incident Mach numbers for the diaphragm middle position from the experiment were compared against those conducted from the model, and good matching was observed. The parametric study results showed that at high‐pressure ratios, diaphragm Positions 1 and 3 could generate a 7.4% increase in shock wave Mach number compared with the diaphragm position‐2 model. Moreover, the diaphragm position‐3 model tends to have a 2% increase in the temperature behind the reflected shock wave compared with the other two positions.
A meta‐analysis on the trust in agrifood supply chains
Authors: Assis Michel T. Q. M. , Lucas Maria Raquel , Rainho Maria José M. 
Published: February 2022

AbstractThe agrifood literature suggests that trust is one of the most prominent and critical aspect for not only the effectiveness of collaboration, but also for improving sustainability performance. In this sense, the understanding of how trust works in agrifood supply chains is essential to find better paths to improve the functioning of those structures. The purpose of this article was to carry out a meta‐analysis on the relationships of trust among the stakeholders in agrifood supply chains, to obtain data on previous publications as well as to justify future research on the search topics. For the bibliometric study, the R software in RStudio and the R packages bibliometrix and biblioshiny were used. The documents were extracted from the Scopus and Web of Science databases. Documents related to the researched topics, that were published in the last 11 years, were collected to the following meta‐analysis. Of 277 documents published from 1995 to 2021, 11 review articles and 74 papers were analyzed. From these publications, we obtained data on the main authors and sources related to trust among the stakeholders in agrifood supply chains, on the methodologies used, as well as on trends for future researches. The present work brings forward data in a unique and up‐to‐date way.
Proteomics and metabolomics combined study on endopathic changes of water‐soluble precursors in Tan lamb during postmortem aging
Authors: Ji Chen , You Liqin , Luo Ruiming 
Published: February 2022

AbstractTan lamb is highly recommended breed in China. It is of great significance to understand the underlying mechanism of how water‐soluble flavor precursors metabolize in Tan lamb muscles during the postmortem aging period. In this study, we investigated the muscle pH, lactate dehydrogenase (LDH) activity, and the variations in water‐soluble flavor‐related metabolites. The proteome changes were profiled to provide insights into the biochemical changes affecting accumulation of water‐soluble flavor precursors in different aging stages (days 0, 4, and 8). The results indicated that pH value considerably decreased from day 0 to day 4, and increased from day 4 to day 8 (p < .05). The activity of LDH significantly increased from day 0 to day 4, and decreased from day 4 to day 8 (p < .05). Postmortem glycolysis was activated in 4 days, which directly affected the variations in metabolic enzymes and triggered the accumulation of flavor‐related carbohydrates. The free amino acids accumulated due to hydrolysis of structural proteins, with 3‐hydroxy‐L‐proline, aspartic acid, and methionine increasing from day 0 to day 4, and aspartic acid, serine, threonine, tyrosine, phenylalanine, and D‐phenylalanine from day 4 to day 8. The inosine and hypoxanthine accumulated due to the degradation of ATP. The results of the present study provide insightful information, revealing the differences in biochemical attributes in Tan lamb muscles caused by postmortem aging.
Expanding the spectrum of mesenchymal neoplasms with NR1D1‐rearrangement
Authors: Lacambra Maribel D. , Antonescu Cristina R. , Chow Chit , Chiu Wang Kei , Demicco Elizabeth G. , Ferguson Peter C. , Swanson David , To Ka‐Fai , Zhang Lei , Dickson Brendan C. 
Published: February 2022

AbstractUndifferentiated mesenchymal neoplasms can be morphologically subclassified based on cell shape; epithelioid tumors may be diagnostically challenging, particularly since they can show morphologic and immunohistochemical overlap with epithelial neoplasms. Following the recent report of an NR1D1::MAML1 gene fusion in an undifferentiated pediatric neoplasm, we performed a retrospective archival review and identified four additional cases of undifferentiated mesenchymal neoplasms with NR1D1‐rearrangement. All four tumors occurred in adult women. The tumors involved superficial and/or deep soft tissues of the extremities or abdomen. Morphologically, they showed a spectrum of overlapping features. In addition to epithelioid cells, two cases also had a prominent spindle cell component. Two cases also had admixed polygonal cells containing prominent cytoplasmic vacuoles with amorphous debris. The immunophenotype was nonspecific but all cases had at least focal keratin expression; this was extensive in two tumors. Targeted RNA‐sequencing revealed two cases each with NR1D1::MAML1 and NR1D1::MAML2 gene fusions. One patient developed lung and liver metastases, and one patient required amputation due to multifocal disease and underlying bone involvement. This study confirms undifferentiated NR1D1‐rearranged sarcoma represents a distinct mesenchymal neoplasm with an epithelioid morphology and potential for aggressive behavior. Further, we offer new insight into the spectrum of clinical, morphologic, immunohistochemical, and molecular findings possible in these rare neoplasms. An awareness of this entity is especially important given the potential for misclassification as a carcinoma.
Disrupted topological organization of resting‐state functional brain networks in cerebral small vessel disease
Authors: Xin Haotian , Wen Hongwei , Feng Mengmeng , Gao Yian , Sui Chaofan , Zhang Nan , Liang Changhu , Guo Lingfei 
Published: February 2022

AbstractWe aimed to investigate alterations in functional brain networks and assess the relationship between functional impairment and topological network changes in cerebral small vessel disease (CSVD) patients with and without cerebral microbleeds (CMBs). We constructed individual whole‐brain, region of interest (ROI) level functional connectivity (FC) networks for 24 CSVD patients with CMBs (CSVD‐c), 42 CSVD patients without CMBs (CSVD‐n), and 36 healthy controls (HCs). Then, we used graph theory analysis to investigate the global and nodal topological disruptions between groups and relate network topological alterations to clinical parameters. We found that both the CSVD and control groups showed efficient small‐world organization in FC networks. However, compared to CSVD‐n patients and controls, CSVD‐c patients exhibited a significantly decreased clustering coefficient, global efficiency, and local efficiency and an increased shortest path length, indicating a disrupted balance between local specialization and global integration in FC networks. Although both the CSVD and control groups showed highly similar hub distributions, the CSVD‐c group exhibited significantly altered nodal betweenness centrality (BC), mainly distributed in the default mode network (DMN), attention, and visual functional areas. There were almost no global or regional alterations between CSVD‐n patients and controls. Furthermore, the altered nodal BC of the right anterior/posterior cingulate gyrus and left cuneus were significantly correlated with cognitive parameters in CSVD patients. These results suggest that CSVD patients with and without CMBs had segregated disruptions in the topological organization of the intrinsic functional brain network. This study advances our current understanding of the pathophysiological mechanisms underlying CSVD.
The radial forearm snake flap: An underutilized technique for fasciocutaneous and osteocutaneous forearm flaps with primary closure
Authors: Gessert Thomas G. , Pflum Zachary E. , Thompson James D. , Hoffman Matthew R. , Sanchez Ruston , Glazer Tiffany A. , Wieland Aaron M. , McCulloch Timothy M. , Hartig Gregory K. 
Published: February 2022

AbstractBackgroundThe radial forearm free flap (RFFF) is associated with troublesome donor site morbidity related to split thickness skin grafting (STSG). The radial forearm snake flap with primary closure of the donor site may reduce donor site complications.MethodsSingle institution, retrospective cohort study comparing rates of delayed donor site wound healing and tendon exposure in 52 patients undergoing radial forearm snake flap and 95 patients undergoing conventional RFFF with STSG closure of the donor site.ResultsTendon exposure occurred in zero (0%) patients undergoing snake flap and four (4.2%) patients undergoing conventional RFFF (0/52 vs. 4/95; p = 0.297). Delayed wound healing occurred in zero (0%) patients undergoing snake flap and 19 (20.0%) patients undergoing conventional RFFF (0/52 vs. 19/95; p < 0.001).ConclusionsThe radial forearm snake flap provides an alternative to conventional RFFF harvest, which enables primary donor site closure with reduced rates of delayed donor site healing.
Experimental analysis of saturated pool boiling of acetone and isopropanol with added surfactant sodium lauryl sulfate over aluminum surface
Authors: Mahapatra Abhishek Sinha , Kar Satya Prakash , Swain Abhilas 
Published: February 2022

AbstractThe present article reports a detailed experimental study to know the effect of adding surfactants to different base fluids. For this purpose, an aqueous solution of different concentrations of surfactant with base fluids was formed and then heated at varying heat flux in a pool boiling apparatus. Acetone and isopropanol have been used as base/boiling fluids with anionic surfactant sodium lauryl sulfate (SLS) of 200, 400, 600, 800, and 1000 PPM concentration. The data obtained by heating surfactant‐based fluids has been compared to the data of heating pure base fluids to establish the role of surfactants and the importance of surfactant concentration, that is, critical micelle concentration (CMC) in pool boiling augmentation. CMC value was found in the case of pool boiling of acetone with an SLS concentration of 400 PPM. However, the CMC value is found to be a lower value of SLS concentration of 200 PPM in the pool boiling process of isopropanol. Therefore, it is interesting to investigate the possible causes of such heat transfer phenomena with different values of surfactant concentration. Variations in heat flux change the degree of superheat of the aluminum heater substrate. The heat transfer performance is studied, and finally, a semi‐empirical correlation is proposed to know the heat transfer coefficient and its dependency over the concentration of surfactant.
The effect of crab burrows on soil‐water dynamics in mangroves
Authors: Arnaud Marie , Baird Andy J. , Morris Paul J. , Taylor Adam , Dang Thuong Huyen , Tran Hong Hanh , Dinh Quang Thoai , Nguyen Tai Tue , Polsenaere Pierre 
Published: February 2022

AbstractMany mangrove ecosystem services, such as carbon sequestration, are closely linked to mangrove soil water content, which in turn is thought to depend on animal burrow density and the properties of the sediment in which the burrows are constructed. We measured the water content in the sediment matrix between crab burrows across 26 plots in a typical, fine‐grained (clay), mangrove soil in the Mekong Delta, Vietnam. We found that the water content of the sediment matrix remained more or less constant throughout the tidal cycle, and was independent of burrow density. Our results suggest that there is little exchange of water between the burrows and the associated sediment matrix and that burrows act as an independent pipe network transporting water through the mangrove soil. To check and extend our findings, we used a numerical groundwater model to simulate an idealized burrow in a range of sediment types. The model results confirmed that fine‐grained mangrove sediments do not drain readily into adjacent animal burrows because of their very low permeability. Our results have important implications for understanding and forecasting mangrove carbon dynamics with sea level rise.
From the voices of supervisees: What is reflective supervision and how does it support their work? (Part I)
Authors: Barron Carla C. , Dayton Carolyn J. , Goletz Jess L. 
Published: February 2022

AbstractReflective supervision/consultation (RS/C) is a relationship for learning that embraces reflection and reflective practice strategies. It is considered best practice within the infant and early childhood mental health (IECMH) field. Based on research with supervisors, essential components of RS/C have been operationalized and used to develop evaluative tools. Little is known, however, about the essential components that supervisees find most useful. This paper, part I of a two‐part series, describes the essential components that supervisees identify as fundamental and ways they believe their work is supported by participation in RS/C. Fifty IECMH professionals located in the United States who received RS/C participated in focus groups or individual interviews. Data were analyzed using a Grounded Theory approach. Essential components of RS/C from the supervisee perspective included supervisee feelings of safety, the development of trust, holding a non‐judgmental stance, being available and present, and consistency and predictability. Additionally, supervisees identified outcomes of RS/C that included components of professional wellness, personal growth, and infant and family engagement. This study adds the supervisee's voice to the identification and operationalization of essential RS/C components and elucidates outcomes of RS/C that supervisees view as connected to their professional role.
Identification of novel inhibitors for Prp protein of Mycobacterium tuberculosis by structure based drug design, and molecular dynamics simulations
Authors: Rajasekhar Sreerama , Das Soumyadip , Karuppasamy Ramanathan , Musuvathi Motilal Balamurali , Chanda Kaushik 
Published: February 2022

AbstractIn this study, we assess the effective inhibition of a series of thiazolidine derivatives (1a–1q) were adopting structure‐based drug design. Thiazolidine is a five‐membered ring structure with thioether and amino groups at positions 1 and 3. Although, thiazolidine may bind to a wide range of protein targets, it is a major heterocyclic core in medicinal chemistry. Different scoring utilities including AutoDock Vina, Glide, and MM/GBSA analysis were performed to commensurate the improvement of screening progress. The evaluated binding affinities were validated by molecular dynamics simulations over a period of 20 ns for the interactions between the Mycobacterium tuberculosis protein PrpR with three novel scaffolds (1b, 1j, and 1k). All the scaffolds exhibited distinct stable interactions with the significant residues like Arg169, Arg197, Tyr248, Arg308, and Gly311 respectively. Further, the inhibitory activities of scaffolds were predicted and evaluated by machine learning based algorithm to rank the above proposed compounds. This study reveals the potential of 1k and 1j as effective inhibitor candidates for the treatment of tuberculosis.
Expression and clinical significance of circular RNA hsa_circ_0003416 in pediatric pulmonary arterial hypertension associated with congenital heart disease
Authors: Huang Yanyun , Su Danyan , Ye Bingbing , Huang Yuqin , Qin Suyuan , Chen Cheng , Zhao Yijue , Pang Yusheng 
Published: February 2022

AbstractBackgroundCircular RNAs (circRNAs) have been found to be involved in the development of pulmonary arterial hypertension (PAH). However, their diagnostic value in pediatric PAH remains unclear. This study aimed to examine the characteristic expression of the circRNA hsa_circ_0003416 in the plasma of children with PAH caused by congenital heart disease (CHD); the potential of hsa_circ_0003416 as a diagnostic biomarker was also investigated.MethodsThe plasma expression levels of hsa_circ_0003416 were determined via quantitative reverse transcription–polymerase chain reaction in 50 CHD patients, 50 PAH patients, and 20 healthy subjects; the associations between hsa_circ_0003416 levels and clinical data were analyzed thereafter. Receiver operating characteristic curves were employed to determine the diagnostic capacity of this circRNA.ResultsExpression levels of hsa_circ_0003416 in plasma were lower in the PAH‐CHD group than in the CHD and healthy control groups (p = 0.009 vs. healthy control group, p = 0.026 vs. CHD group). Moreover, hsa_circ_0003416 was found to be negatively associated with B‐type natriuretic peptide (r = −0.342, p = 0.013). In addition, the area under the curve of hsa_circ_0003416 levels in plasma was 0.721 (95% confidence intervals = 0.585–0.857, p = 0.004), suggesting that it has a promising diagnostic value.ConclusionsOverall, hsa_circ_0003416 was found to be significantly downregulated in children with PAH‐CHD and to be potent as a biomarker for PAH‐CHD diagnosis.
Brown adipose tissue activation is not related to hypermetabolism in emphysematous chronic obstructive pulmonary disease patients
Authors: Sanders Karin J.C. , Wierts Roel , van Marken Lichtenbelt Wouter D. , de Vos‐Geelen Judith , Plasqui Guy , Kelders Marco C.J.M. , Schrauwen‐Hinderling Vera B. , Bucerius Jan , Dingemans Anne‐Marie C. , Mottaghy Felix M. , Schols Annemie M.W.J. 
Published: February 2022

AbstractBackgroundBrown adipose tissue (BAT) has been primarily researched as a potential target for mitigating obesity. However, the physiological significance of BAT in relation to cachexia remains poorly understood. The objective of this study was to investigate the putative contribution of BAT on different components of energy metabolism in emphysematous chronic obstructive pulmonary disease (COPD) patients.MethodsTwenty COPD patients (mean ± SD age 62 ± 6, 50% female, median [range] BMI 22.4 [15.1–32.5] kg/m2 and 85% low FFMI) were studied. Basal metabolic rate (BMR) was assessed by ventilated hood, total daily energy expenditure (TDEE) by doubly labelled water and physical activity by triaxial accelerometry. BMR was adjusted for fat‐free mass (FFM) as assessed by deuterium dilution. Analysis of BAT and WAT was conducted in a subset of ten patients and six age‐matched, gender‐matched and BMI‐matched healthy controls. BAT glucose uptake was assessed by means of cold‐stimulated integrated [18F]FDG positron‐emission tomography and magnetic resonance imaging. WAT was collected from subcutaneous abdominal biopsies to analyse metabolic and inflammatory gene expression levels. Lung function was assessed by spirometry and body plethysmography and systemic inflammation by high sensitivity C‐reactive protein.ResultsMean TDEE was 2209 ± 394 kcal/day, and mean BMR was 1449 ± 214 kcal/day corresponding to 120% of predicted. FFM‐adjusted BMR did not correlate with lung function or C‐reactive protein. Upon cooling, energy expenditure increased, resulting in a non‐shivering thermogenesis of (median [range]) 20.1% [3.3–41.3] in patients and controls. Mean BAT glucose uptake was comparable between COPD and controls (1.5 [0.1–6.2] vs. 1.1 [0.7–3.9]). In addition, no correlation was found between BMR adjusted for FFM and BAT activity or between cold‐induced non‐shivering energy expenditure and BAT activity. Gene expression levels of the brown adipocyte or beige markers were also comparable between the groups. No (serious) adverse events were reported.ConclusionsAlthough COPD patients were hypermetabolic at rest, no correlation was found between BMR or TDEE and BAT activity. Furthermore, both BAT activity and gene expression levels of the brown adipocyte or beige markers were comparable between COPD patients and controls.