bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structures of the Type IX Secretion/gliding motility motor from across the phylum Bacteroidetes
Authors: James Rory Hennell , Deme Justin C. , Hunter Alicia , Berks Ben C. , Lea Susan M. 
Published: January 2022

AbstractGliding motility using cell surface adhesins and export of proteins by the Type IX Secretion System (T9SS) are two phylum-specific features of the Bacteroidetes. Both of these processes are energized by the GldLM motor complex which transduces the protonmotive force at the inner membrane into mechanical work at the outer membrane. We previously used cryo-electron microscopy to solve the structure of the GldLM motor core from Flavobacterium johnsoniae at 3.9 Å resolution (Nat Microbiol (2021) 6: 221-233). Here we present structures of homologous complexes from a range of pathogenic and environmental Bacteroidetes species at up to 3.0 Å resolution. These structures show that the architecture of the GldLM motor core is conserved across the Bacteroidetes phylum although there are species-specific differences at the N-terminus of GldL. The resolution improvements reveal a cage-like structure that ties together the membrane-proximal cytoplasmic region of GldL and influences gliding function. These findings add detail to our structural understanding of bacterial ion-driven motors that drive the T9SS and gliding motility.ImportanceMany bacteria in the Bacteroidetes phylum use the Type IX Secretion System to secrete proteins across their outer membrane. Most of these bacteria can also glide across surfaces using adhesin proteins that are propelled across the cell surface. Both secretion and gliding motility are driven by the GldLM protein complex which forms a nanoscale electrochemical motor. We used cryo-electron microscopy to study the structure of the GldLM protein complex from different species including the human pathogens Porphyromonas gingivalis and Capnocytophaga canimorsus. The organisation of the motor is conserved across species, but we find species-specific structural differences and resolve motor features at higher resolution. This work improves our understanding of the Type IX Secretion System, which is a virulence determinant in human and animal diseases.
CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium
Authors: Prieto Susana , Dubra Geronimo , Camasses Alain , Simboeck Elisabeth , Aznar Ana Bella , Begon-Pescia Christina , Pirot Nelly , Gerbe François , Angevin Lucie , Jay Philippe , Krasinska Liliana , Fisher Daniel 
Published: January 2022

AbstractCDK8 and CDK19 form a conserved cyclin-dependent kinase subfamily that interacts with the essential transcription complex, Mediator, and also promotes transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II. Cells lacking either CDK8 or CDK19 are viable and have limited transcriptional alterations, but whether the two kinases redundantly control cell differentiation is unknown. Here, we find that CDK8 is dispensable for RNA polII CTD phosphorylation, regulation of gene expression, normal intestinal homeostasis and efficient tumourigenesis in mice. Furthermore, CDK8 is largely redundant with CDK19 in the control of gene expression. Yet, while their combined deletion in intestinal organoids reduces long-term proliferative capacity, it is not lethal and allows differentiation. Nevertheless, in double mutant organoids, the cystic fibrosis transmembrane conductance regulator (CFTR) pathway is transcriptionally and functionally downregulated, leading to mucus accumulation and increased secretion by goblet cells. This phenotype can be recapitulated by pharmacological inhibition of CDK8/19 kinase activity. Thus, the Mediator kinases are not essential for cell proliferation and differentiation, but they cooperate to regulate tissue-specific transcriptional programmes.
Multidimensional drivers: exploring contractor rule violations in the construction industry
Authors: Liu Junying , Wang Yuqing , Wang Zhixiu 
Published: January 2022

PurposeThis research aims to build a three-tiered driver system that entices contractor rule violations and explores the importance and the relationships among these drivers, hence providing theoretical support for the contractor rule violations governance.Design/methodology/approachA literature review based on fraud diamond theory identified drivers from Pressure, Opportunity, Rationalization and Capability that drive contractor rule violations. In the Chinese context, through feedback, discussion and analysis of semistructured interviews with ten experts, an improved three-tiered driver system was drafted. Based on this system, a survey was conducted and scored with experts to provide the data for this research. The decision-making trial and evaluation laboratory (DEMATEL) method was used to determine relationships and influences between factors, and the DEMATEL-based analytic network process method was used to weigh these factors.FindingsThis paper systematically studied the drivers of contractor rule violations, specifically, the results showed that pressure had an important driving effect across the driver system, and those five factors – poor cultural atmosphere, weak internal control, prior experience, moral disengagement and information asymmetry – had the most influence on contractor rule violations. The results also indicated the strong effect pressure has on enticing rule violations and revealed that culture atmosphere and internal company governance played crucial roles in the occurrence of rule violations.Practical implicationsThis study provided construction practitioners with a robust tool to analyze the drivers of contractor rule violations. The rule violation drivers in the construction practice scenes identified in this study can provide more direct and effective violation-related guidance for contractors, regulators and the industry.Originality/valueBased on the new perspective of fraud diamond, this paper systematically bulit a three-tiered driver system combining theory with practice. This study contributed to understand the driver mechanism of contractor rule violations especially the importance of internal factors of contractors, which provided theory reference for compliance governance of construction industry.
Shaping the attitudes of Russian managers in ethical issues – personal attributes and environmental pressure
Authors: Oberhauser Marc , Holtbrügge Dirk , Gurkov Igor 
Published: January 2022

PurposeThe purpose of this study is to investigate how the attitudes of Russian managers are affected by personal attributes, environmental conditions and also cognitive processes.Design/methodology/approachBased on social cognitive theory, the authors developed hypotheses and tested them against data collected from 173 Russian managers via an online survey. A linear regression analysis revealed several determinants of ethical attitudes within the Russian context.FindingsThe findings suggest that personal values (i.e. political orientation), environmental conditions (i.e. hierarchical level, ownership – state-owned versus private – of the current employer, industry in which a manager works) as well as cognitive processes (i.e. the presence (absence) of multilingualism at the workplace) strongly affect ethical attitudes of Russian managers in several issues related to both job ethics (relations inside the organization) and business ethics (relations outside the organization).Practical implicationsRevealing a positive effect of multilingualism as cognitive process on managers' ethical attitudes, this study calls for incorporating a second lingua franca, for example, English, within the working context.Originality/valueThe study provides an in-depth investigation of the determinants of ethical attitudes in Russia. Conducting a single-country study, the authors are able to reveal locally meaningful determinants that may otherwise be overlooked.
Matching goal-based incentive systems with cross-functional integration to improve operation and innovation performance
Authors: Kang Mingu , Ki-Hyun Um. , Shou Yongyi , Roh James Jungbae 
Published: January 2022

PurposeCross-functional integration has been an important factor for manufacturing firms' performance outcomes. The study aims to expand previous research by investigating the moderating role of goal-based incentive systems in the relationship between cross-functional integration and competitive performance.Design/methodology/approachBased on multi-source data from 269 manufacturing firms around the world, regression analysis is used to test the proposed research model.FindingsThe authors' findings suggest that cross-functional integration enhances manufacturers' innovation and operational performance. Moreover, cross-functional integration has a stronger impact on operational performance when firms implement a well-designed goal-based incentive system. However, the authors find that the goal-based incentive system does not moderate the relationship between cross-functional integration and innovation performance.Originality/valueThe study, by investigating the fit between goal-based incentive systems and cross-functional integration, provides practical insights into the ways that firms apply cross-functional integration and goal-based incentive systems to enhance competitive performance.
An acceptance model for sports technologies: the effects of sports motivation, sports type and context-aware characteristics
Authors: Oc Yusuf , Toker Aysegul 
Published: January 2022

PurposeThis study explores the drivers behind sports technology use and identifies the need for a new conceptualization of sports technology adoption. To address this issue, the authors create a new construct, “context-awareness,” with four dimensions: tracking, coaching, sharing and gamification.Design/methodology/approachThe paper uses a mixed-method approach, including in-depth interviews and partial least squares structural equation modeling. The proposed model combines technology acceptance frameworks with the Sports Motivation Scale and a novel context-awareness scale. It is empirically tested with a diverse sample of 600 respondents to identify use-intention differences according to sports motivation and sport types.FindingsThe paper reveals group differences in sports type (dynamic vs nondynamic) and sports motivation (intrinsic vs extrinsic) regarding sports technology use. It also suggests that perceived technology characteristics mediate the relationship between context-aware features and intention to use.Originality/valueThis research introduces a new construct of “context-awareness” into the literature on new technology acceptance. The proposed model combines insights from information systems, sports science, sports marketing and sports medicine to explain the adoption of complex technology.
Experiences of staff working in a mental health trust during the COVID-19 pandemic and appraisal of staff support services
Authors: Jones Abbeygail , Zhang Shuo , Woodburn Amy , Dorrington Sarah , Beck Alison , Winter Helen 
Published: January 2022

PurposeThe health and well-being of healthcare staff came into focus during the coronavirus disease-2019 (COVID-19) pandemic as already strained workforces responded to new and additional challenges. Organisational support services made efforts to adapt staff support provision. However, most literature and recommendations are centred on surveys of medical and clinical staff. The present study included staff across clinical and non-clinical workforces within a mental health trust over the course of the COVID-19 pandemic to date, and aimed to understand workforces' access to and experiences of organisational support.Design/methodology/approachThe current study was a qualitative one using convenience and purposive sampling. Semi-structured individual and group interviews were conducted using a topic guide. Reflexive thematic analysis was used in a phenomenological framework to analyse data.Findings35 staff, broadly representative of the trust workforce, were recruited. Six global themes summarised the experiences of staff in relation to work practices, personal well-being and support access over the first year of the COVID-19 pandemic: COVID-19 disease, interpersonal relationships, individual considerations, change, working environment and support.Practical implicationsThe findings from the study have implications for organisational support provisions for healthcare workers and the dissemination of these services.Originality/valueAcknowledging the multi-various experiences of different workforces within National Healthcare Service organisations and how these change over time will facilitate innovative changes to staff support provision.
Default to truth in information behavior: a proposed framework for understanding vulnerability to deceptive information
Authors: Zimmerman Tara , Njeri Millicent , Khader Malak , Allen Jeff 
Published: January 2022

Purpose
This study aims to recognize the challenge of identifying deceptive information and provides a framework for thinking about how we as humans negotiate the current media environment filled with misinformation and disinformation.

Design/methodology/approach
This study reviews the influence of Wilson’s (2016) General Theory of Information Behavior (IB) in the field of information science (IS) before introducing Levine’s Truth-Default Theory (TDT) as a method of deception detection. By aligning Levine’s findings with published scholarship on IB, this study illustrates the fundamental similarities between TDT and existing research in IS.

Findings
This study introduces a modification of Wilson’s work which incorporates truth-default, translating terms to apply this theory to the broader area of IB rather than Levine’s original face-to-face deception detection.

Originality/value
False information, particularly online, continues to be an increasing problem for both individuals and society, yet existing IB models cannot not account for the necessary step of determining the truth or falsehood of consumed information. It is critical to integrate this crucial decision point in this study’s IB models (e.g. Wilson’s model) to acknowledge the human tendency to default to truth and thus providing a basis for studying the twin phenomena of misinformation and disinformation from an IS perspective. Moreover, this updated model for IB contributes the Truth Default Framework for studying how people approach the daunting task of determining truth, reliability and validity in the immense number of news items, social media posts and other sources of information they encounter daily. By understanding and recognizing our human default to truth/trust, we can start to understand more about our vulnerability to misinformation and disinformation and be more prepared to guard against it.
Be my friend! Cultivating parasocial relationships with social media influencers: findings from PLS-SEM and fsQCA
Authors: Aw Eugene Cheng-Xi , Tan Garry Wei-Han , Chuah Stephanie Hui-Wen , Ooi Keng-Boon , Hajli Nick 
Published: January 2022

PurposeThe emergence of social media has brought the influencer marketing landscape to an unprecedented level, where many ordinary people are turning into social media influencers. The study aims to construct and validate a model to yield strategic insights on the relevance of content curation, influencer–fans interaction and parasocial relationships development in fostering favorable endorsement outcomes (i.e. purchase intention).Design/methodology/approachThe present study analyzes data from a survey of 411 consumers using partial least squares-structural equation modelling (PLS-SEM) and fuzzy set qualitative comparative analysis (fsQCA) to understand the net and combined effects of content attributes, interaction strategies and parasocial relationships on purchase intention.FindingsPLS-SEM results reveal that content attributes (i.e. prestige and expertise) and interaction strategies (i.e. interactivity and self-disclosure) positively influence parasocial relationships, and in turn, lead to high purchase intention. Findings from fsQCA indicate six solutions with different combinations of content attributes, interaction strategies and parasocial relationships that sufficiently explain high purchase intention.Originality/valueThe present study demonstrates the roles of content attributes and interaction strategies in engendering parasocial relationship and the endorsement outcome (i.e. purchase intention) from both linear and non-linear (complexity) perspectives.
Impact of bundling on the omnichannel supply chain under price competition
Authors: Jena Sarat Kumar 
Published: January 2022

Purpose
Many e-commerce firms suffer from high returns because of inaccurate and incomplete product information. Omnichannel and bundling settings can help firms improve operational efficiency and lower returns costs. However, no studies have been conducted on omnichannel supply chains considering bundling strategies. The purpose of this study is to examine the comparison between test-in-store-and-buy-online (TSBO) and online retail, comparing manufacturers’ bundling with retailers’ bundling.

Design/methodology/approach
The supply chain discussed here consists of two competitive manufacturers and one retailer. The retailer sells both manufacturers' products online and displays one manufacturer's product in a showroom who bears the display cost. Stackelberg game theory is used to develop mathematical models that help manufacturers and retailers make the most effective decisions. Here, the manufacturer is the Stackelberg leader, while the retailer is the follower. Using the backward induction approach, the authors determined the optimal values for selling price, wholesale price and service effort level.

Findings
The results show that the total TSBO retailing profit under manufacturer bundling is highest when the second manufacturer integrates with the online retailer. The result additionally establishes that when the bundling cost exceeds a certain threshold (1.5), the total profit is higher for the non-integrated type of supply chain channel as compared to the integrated retailer bundling-based configuration.

Practical implications
The operations and logistics manager will likely undertake the TSBO omnichannel strategy during manufacturers bundling and retailer bundling under the integrated strategy.

Originality/value
The main contribution of the study is to examine the effect of TSBO retailing on supply chains profit and individual decision-making under different bundling strategies. The authors developed different mathematical models in the TSBO retailing and bundling context and extended the earlier work in the area of integration frame.
The role of CEOs' human capital in sustaining superior performance–empirical evidence from China
Authors: Guan Jian , Deng Fang , Zhou Dao 
Published: January 2022

PurposeFocusing on the important representative of firm intellectual capital (IC), this research explores the effects of chief executive officer’s (CEOs') managerial human capitals on sustaining superior performance in Chinese transition economy to prove the dynamic and strategic value of IC and fulfill the gap of lacking emerging market studies in this research field.Design/methodology/approachBased on dynamic managerial capability theoretical framework, the authors propose a dynamic management path to analyze the influencing mechanism of CEOs' managerial human capitals to firm performance persistence and the moderating effect of environment uncertainty. Using a panel data of Chinese publicly listed firms from 2008 to 2017, it adopts dynamic first-order autoregressive models to examine these hypotheses. Several tests are conducted to further analyze and ensure that the results are robust and reliable.FindingsThese managerial human capitals reveal heterogenous impacts on sustaining superior performance, and environment uncertainty is a valid moderating variable to further distinguish their dynamic values. The supplementary analyses show the integrating effect of an MBA degree and output functional experience is positive and significant, and the results in Chinese state-owned and private firm subsamples are distinct.Practical implicationsIt is beneficial for corporate stakeholders to judge and select CEOs and for policymakers to improve the efficiency advantage of IC in Chinese emerging market.Originality/valueThis study first explores the relationship between CEOs' managerial human capitals and superior performance persistence. Through introducing a dynamic perspective, it has extended existing performance persistence research into individual level and provided a new intellectual source of sustainable competitive advantages.
How does coaching leadership promote employee's constructive deviance? Affective events perspective
Authors: Cui Zhisong , Wang Hongyu , Nanyangwe Chilombo Namwinga 
Published: January 2022

PurposeAdopting an affective events perspective, this paper proposes and tests a moderated-mediation model linking coaching leadership (CL), positive emotion at work (PEW), proactive personality (PP) and constructive deviance (CD).Design/methodology/approachAltogether, 225 supervisor-subordinate pairs from 45 teams within a large Chinese manufacturing enterprise took part in our study. To keep common method bias to a minimal, two sources of data were used (subordinates and their direct supervisors).Findings(1) CL and employee CD have a positive association; (2) employee PEW mediates the connection between CL and employee CD; (3) the positive association between CL and follower PEW is moderated by employee PP such that PP strengthens the CL-PEW relationship (4) employee PP accentuates the indirect impact of CL on employee CD via employee PEW. Specifically, the indirect link is insignificant when PP is low.Originality/value(1) The results of this study enrich the CD literature; (2) the work puts forward a simple but foundational framework for understanding the CL process; (3) the third contribution arises from examining the influence of employee PP on the relationship between CL and employee CD.
Sustainable design guidelines for additive manufacturing applications
Authors: Agrawal Rohit 
Published: January 2022

Purpose
Additive manufacturing (AM) technologies have tremendous applications in industries owing to their unique advantages. Sustainable AM (SAM) is gaining significance because of lightweight structures, lattice geometries and customized parts for industrial applications. To facilitate design for SAM, design guidelines from AM and environment viewpoints are to be analyzed. In this context, this paper aims to present the analysis of SAM guidelines.

Design/methodology/approach
This work divides 26 identified SAM guidelines into four categories. Grey axiomatic design was used to calculate the weights of guidelines categories. Further, the grey technique for order preference by similarity to ideal solution was used as a solution methodology to prioritize the SAM guidelines.

Findings
The top identified guidelines are “Design for reusability” and “Optimize part orientation for build time and roughness.” Implementing proper design guidelines leads to many sustainable benefits such as minimum material consumption, energy consumption and emissions.

Originality/value
This study would facilitate Am product designers to deploy prioritized guidelines for enhancing the effectiveness of the additively manufactured product with sustainability benefits. The prioritized guidelines would guide the AM product designers to take maximum advantage of the AM process by deploying design for AM and design for environment guidelines. This study contributed a structured approach for design engineers and practitioners to deploy guidelines during the early stages of product design to ensure AM feasibility with minimal environmental impact.