bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a scientific data search infrastructure
Authors: Orhean Alexandru Iulian , Giannakou Anna , Antypas Katie , Raicu Ioan , Ramakrishnan Lavanya 
Published: October 2022

SummaryThe ability to search over large scientific datasets has become crucial to next‐generation scientific discoveries as data generated from scientific facilities grow dramatically. In previous work, we developed and deployed ScienceSearch, a search infrastructure for scientific data which uses machine learning to automate metadata creation. Our current deployment is deployed atop a container based platform at a HPC center. In this article, we present an evaluation and discuss our experiences with the ScienceSearch infrastructure. Specifically, we present a performance evaluation of ScienceSearch's infrastructure focusing on scalability trends. The obtained results show that ScienceSearch is able to serve up to 130 queries/min with latency under 3 s. We discuss our infrastructure setup and evaluation results to provide our experiences and a perspective on opportunities and challenges of our search infrastructure.
BH4Ng+ (Ar−Rn): Viable Compounds with a B−Ng Covalent Bond
Authors: Pino‐Rios Ricardo , Vásquez‐Espinal Alejandro , Pan Sudip , Cerpa Erick , Tiznado William , Merino Gabriel 
Published: October 2022

AbstractIn this work, we explore, using high‐level calculations, the ability of BH4+ to interact with noble gases. The He system is energetically unstable, while the Ne system could only be observed at cryogenic temperatures. In the case of the Ar, Kr and Xe systems, all are energetically stable, even at room temperature. The different chemical bond descriptors reveal a covalent character between B and the noble gas from Ar to Rn. However, this interaction gradually weakens the multicentric bond between the boron atom and the H2 fragment. Thus, although BH4Rn+ exhibits a strong covalent bond, it tends to dissociate at room temperature into BH2Rn++H2.
Photoinduced Intervalence Charge Transfers: Spectroscopic Tools to Study Fundamental Phenomena and Applications
Authors: Ramírez‐Wierzbicki Ivana , Cotic Agustina , Cadranel Alejandro 
Published: October 2022

AbstractThe front cover artwork is provided by Dr. Alejandro Cadranel's group at the University of Buenos Aires and the Friedrich‐Alexander Universität Erlangen‐Nürnberg. The image shows a ground state that forms, upon photon absorption, an excited state mixed valence system, which is characterized by a double‐well potential energy surface. Inspection of the excited state with light reveals photoinduced intervalence charge transfers (cover design by Gonzalo Peñaloza). Read the full text of the Concept at 10.1002/cphc.202200384.
Activity‐Based Models to Predict Kinetics of Levulinic Acid Esterification
Authors: Klinksiek Marcel , Baco Sindi , Leveneur Sébastien , Legros Julien , Held Christoph 
Published: October 2022

AbstractThe solvent is of prime importance in biomass conversion as it influences dissolution, reaction kinetics, catalyst activity and thermodynamic equilibrium of the reaction system. So far, activity‐based models were developed to predict kinetics and equilibria, but the influence of the catalyst on kinetics has not been succesfully predicted by thermodynamic models. In this work, the thermodynamic model ePC‐SAFT advanced was used to predict the activities of the reactants and of the catalyst at various conditions (temperature, reactant concentrations, γ‐valerolactone GVL cosolvent addition, catalyst concentration) for the homogeneously acid‐catalyzed esterification of levulinic acid (LA) with ethanol. Different kinetic models were applied, and it was found that the catalyst influence on kinetics could be predicted correctly by simultaneously solving the dissociation equilibrium of H2SO4 catalyst along the reaction coordinate and by relating reaction kinetics to proton activity. ePC‐SAFT advanced model parameters were only fitted to reaction‐independent phase equilibrium data. The key reaction properties were determined by applying ePC‐SAFT advanced to one experimental kinetic curve for a set of temperatures, yielding the reaction enthalpy at standard state
, activation energy
and the intrinsic reaction rate constant k=0.011 s−1 at 323 K, which is independent of catalyst concentration. The new procedure allowed an a‐priori identification of the effects of catalyst, solvent and reactant concentration on LA esterification.
Nucleic Acid Aptamers for Pesticides, Toxins, and Biomarkers in Agriculture
Authors: Hu Rongping , Shi Jun , Tian Cheng , Chen Xiaojuan , Zuo Hua 
Published: October 2022

AbstractNucleic acid aptamers are short single‐stranded DNA/RNA (ssDNA/RNA) oligonucleotides that can selectively bind to the targets. They are widely used in medicine, biosensing, and diagnostic assay. They have also been identified and extensively used for various targets in agriculture. In this review we summarize the progress of nucleic acid aptamers on pesticides (herbicides, insecticides, and fungicides), toxins, specific biomarkers of crops, and plant growth regulators in agricultural field in recent years. The basic process of aptamer selection, the already identified DNA/RNA aptamers and the aptasensors are discussed. We also discuss the future perspectives and the challenges for aptamer development in agriculture.
Dynamic 3D Combinatorial Generation of hPSC‐Derived Neuromesodermal Organoids With Diverse Regional and Cellular Identities
Authors: Whye Dosh , Wood Delaney , Kim Kristina H. , Chen Cidi , Makhortova Nina , Sahin Mustafa , Buttermore Elizabeth D. 
Published: October 2022

AbstractNeuromesodermal progenitors represent a unique, bipotent population of progenitors residing in the tail bud of the developing embryo, which give rise to the caudal spinal cord cell types of neuroectodermal lineage as well as the adjacent paraxial somite cell types of mesodermal origin. With the advent of stem cell technologies, including induced pluripotent stem cells (iPSCs), the modeling of rare genetic disorders can be accomplished in vitro to interrogate cell‐type specific pathological mechanisms in human patient conditions. Stem cell‐derived models of neuromesodermal progenitors have been accomplished by several developmental biology groups; however, most employ a 2D monolayer format that does not fully reflect the complexity of cellular differentiation in the developing embryo. This article presents a dynamic 3D combinatorial method to generate robust populations of human pluripotent stem cell‐derived neuromesodermal organoids with multi‐cellular fates and regional identities. By utilizing a dynamic 3D suspension format for the differentiation process, the organoids differentiated by following this protocol display a hallmark of embryonic development that involves a morphological elongation known as axial extension. Furthermore, by employing a combinatorial screening assay, we dissect essential pathways for optimally directing the patterning of pluripotent stem cells into neuromesodermal organoids. This protocol highlights the influence of timing, duration, and concentration of WNT and fibroblast growth factor (FGF) signaling pathways on enhancing early neuromesodermal identity, and later, downstream cell fate specification through combined synergies of retinoid signaling and sonic hedgehog activation. Finally, through robust inhibition of the Notch signaling pathway, this protocol accelerates the acquisition of terminal cell identities. This enhanced organoid model can serve as a powerful tool for studying normal developmental processes as well as investigating complex neurodevelopmental disorders, such as neural tube defects. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Robust generation of 3D hPSC‐derived spheroid populations in dynamic motion settingsSupport Protocol 1: Pluronic F‐127 reagent preparation and coating to generate low‐attachment suspension culture dishesBasic Protocol 2: Enhanced specification of hPSCs into NMP organoidsSupport Protocol 2: Combinatorial pathway assay for NMP organoid protocol optimizationBasic Protocol 3: Differentiation of NMP organoids along diverse cellular trajectories and accelerated terminal fate specification into neurons, neural crest, and sclerotome derivatives
Clinical status and assessment of caries on first permanent molars in a group of 6‐ to 13‐year‐old Tunisian school children
Authors: Chouchene Farah , Masmoudi Fatma , Baaziz Ahlem , Maatouk Fethi , Ghedira Hichem 
Published: October 2022

AbstractAimThe present survey aimed to highlight the clinical status of first permanent molars (FPMs) among a group of children aged between 6 and 13 years in public primary schools in Tunisia and to determine the association between FPMs' dental caries, gingival bleeding, malocclusion, dental fluorosis, and enamel defects.Materials and MethodsThe survey involved a cross‐sectional study based on a dental examination conducted in public primary schools in Monastir Tunisia. A dental caries assessment was performed on FPMs using the International Caries Detection and Assessment System classification; the number of carious lesions in permanent and temporary dentition was established using the decayed/missing/filled teeth (DMFT) index. The Gingival Index and the Dental Aesthetic Index were used to determine the occurrence of gingival bleeding and malocclusions. Dean's index and the modified Development Defects of Enamel index were used to define the enamel defects. The χ2 test was used to assess the difference between more than two groups, and the level of statistical significance was set at .05%.ResultsA total of 545 children and 2080 FPMs were examined. The prevalence of dental caries in FPMs was recorded to be 35.8%. The overall mean DMFT index of the study population was 1.62 and the mean DMFT index was 1.41. The proportion of carious FPMs increased significantly with the age of the children (p < .05). The mandibular first permanent molar presented higher caries prevalence than its maxillary counterpart (p < .05). The presence of surfaces affected by molar incisor hypomineralization was recorded in 4.3% and the presence of surfaces affected by fluorosis was recorded in 4.6% of FPMs. No association was reported between FPMs' dental caries, gingival bleeding, malocclusion, and enamel defects (p > .05).ConclusionAlthough the prevalence of caries in FPMs was considered moderate, health promotion programs should be implemented on a large scale to decrease the prevalence of dental caries among school children.
Predictors of outcomes after surgery for medically intractable insular epilepsy: A systematic review and individual participant data meta‐analysis
Authors: Obaid Sami , Chen Jia‐Shu , Ibrahim George M. , Bouthillier Alain , Dimentberg Evan , Surbeck Werner , Guadagno Elena , Brunette‐Clément Tristan , Shlobin Nathan A. , Shulkin Aidan , Hale Andrew T. , Tomycz Luke D. , Von Lehe Marec , Perry Michael Scott , Chassoux Francine , Bouilleret Viviane , Taussig Delphine , Fohlen Martine , Dorfmuller Georg , Hagiwara Koichi , Isnard Jean , Oluigbo Chima O. , Ikegaya Naoki , Nguyen Dang K. , Fallah Aria , Weil Alexander G. 
Published: October 2022

AbstractInsular epilepsy (IE) is an increasingly recognized cause of drug‐resistant epilepsy amenable to surgery. However, concerns of suboptimal seizure control and permanent neurological morbidity hamper widespread adoption of surgery for IE. We performed a systematic review and individual participant data meta‐analysis to determine the efficacy and safety profile of surgery for IE and identify predictors of outcomes. Of 2483 unique citations, 24 retrospective studies reporting on 312 participants were eligible for inclusion. The median follow‐up duration was 2.58 years (range, 0‐17 years), and 206 (66.7%) patients were seizure‐free at last follow‐up. Younger age at surgery (≤18 years; HR = 1.70, 95% CI = 1.09‐2.66, P = .022) and invasive EEG monitoring (HR = 1.97, 95% CI = 1.04‐3.74, P = .039) were significantly associated with shorter time to seizure recurrence. Performing MR‐guided laser ablation or radiofrequency ablation instead of open resection (OR = 2.05, 95% CI = 1.08‐3.89, P = .028) was independently associated with suboptimal or poor seizure outcome (Engel II‐IV) at last follow‐up. Postoperative neurological complications occurred in 42.5% of patients, most commonly motor deficits (29.9%). Permanent neurological complications occurred in 7.8% of surgeries, including 5% and 1.4% rate of permanent motor deficits and dysphasia, respectively. Resection of the frontal operculum was independently associated with greater odds of motor deficits (OR = 2.75, 95% CI = 1.46‐5.15, P = .002). Dominant‐hemisphere resections were independently associated with dysphasia (OR = 13.09, 95% CI = 2.22‐77.14, P = .005) albeit none of the observed language deficits were permanent. Surgery for IE is associated with a good efficacy/safety profile. Most patients experience seizure freedom, and neurological deficits are predominantly transient. Pediatric patients and those requiring invasive monitoring or undergoing stereotactic ablation procedures experience lower rates of seizure freedom. Transgression of the frontal operculum should be avoided if it is not deemed part of the epileptogenic zone. Well‐selected candidates undergoing dominant‐hemisphere resection are more likely to exhibit transient language deficits; however, the risk of permanent deficit is very low.
Heat transfer study in the exploitation of argillaceous‐silt natural gas hydrate reservoirs
Authors: Jiang Shuxian , Song Jinze , Liu Chang , Xiong Youming , Pang Weixin , He Yufa 
Published: October 2022

AbstractThe paper investigates the heat transfer in the exploitation of offshore argillaceous‐silt natural gas hydrate reservoirs considering sand control. The temperature prediction model is established in this investigation. The coupled pressure‐temperature model of the flowing fluid inside the wellbore is also presented. The sand control for argillaceous‐silt natural gas hydrate reservoirs mainly brings two effects into the temperature and pressure profiles simulation, including the moderate sand control and the Joule–Thompson effect. The moderate sand control is reflected by the volume and particle size of produced sand into the wellbore in the mathematical derivation. The Joule–Thompson is considered in the model due to the small diameter of sand control screens. The experiment is designed to measure the pressure drop caused by various mesh diameters of sand control screens. Subsequently, the regression relationship between the pressure drop and the mesh diameter is concluded to calculate the temperature change at the sand control screen. The simulation of heat transfer helps to analyze secondary hydrate formation risk in the wellbore. The proposed model identifies the high‐risk location of the secondary hydrate formation. The sand control effect and well geometry effect are discussed quantitatively. The strict sand control in the argillaceous‐silt natural gas hydrate (NGH) sediment exploitation reduces the risk of secondary hydrate formation significantly; however, it also has a negative effect on natural gas production. To balance the sand control and the prevention of secondary hydrate formation risk, it is suggested to install the heating electrode in the high‐risk location to ensure flow safety with acceptable sand control precision. The heat provided by heat electrodes is calculated by the model presented in this paper. The model can be used to determine the proper arrangement of heat electrodes. The paper also describes the secondary hydrate formation by adjusting the well geometry. The formation depth of the NGH reservoir and the sea interval should be considered in the risk analysis of the secondary hydrate formation. Additionally, the effects of wall thickness and wall thermal properties are evaluated and discussed. It is recommended to optimize the riser thickness with a small thermal conductivity value to minimize the secondary hydrate formation risk, which is more efficient compared to adjusting the cement sheath.
A unified approach for the solution of fluid‐solid interaction problems with hyperelastic deformation in internal flows
Authors: Tandis Emad , Ashrafizadeh Ali 
Published: October 2022

AbstractIn the single domain method for solving fluid–solid interaction (FSI) problems, a unified formulation is used for the entire computational domain. In such monolithic FSI solvers, all of the governing equations are solved simultaneously. In the present study, the single domain method is further extended to an interface‐tracking FSI solver which accounts for mesh movement via an Arbitrary Lagrangian–Eulerian (ALE) description of the governing equations. The focus is on internal flow problems with large deformation. Pressure and velocity are selected as the dependent variables for both solid and fluid parts of the computational domain. A distinguishing feature of the proposed method is that the governing equations at the interface are discretized in a conservative manner. Interfacial boundary conditions are enforced via a pressure–velocity splitting method to convert the kinematic and dynamic conditions at the interface into pressure–velocity relations. A PISO‐like procedure is used to solve the discretized equations. In order to evaluate the proposed solver, strongly‐coupled FSI benchmark test cases are employed. The performance of the proposed method and computational results are also compared with those obtained by a conventional partitioned solver. The results show that the proposed solver provides more accurate results on a coarser mesh compared to the benchmark solutions. The proposed method is also capable of solving strongly coupled problems for which the partitioned solver fails to converge.
Using the serratus anterior free flap for dynamic facial reanimation: Systematic review
Authors: Janik Stefan , Marijic Blazen , Faisal Muhammad , Grasl Stefan , Tzou Chieh‐Han J. , Rodriquez‐Lorenzo Andres , Seemann Rudolf , Leonhard Matthias , Erovic Boban M. 
Published: October 2022

AbstractIt was the purpose of this study to evaluate the role of the serratus anterior free flap (SAFF) with its long thoracic nerve (LTN) as composite flap for dynamic facial reanimation. A total of 10 studies, published between 2004 and 2021, met inclusion criteria. Clinical data of 48 patients were used for the systematic review and analysis. One to three slips were used, mainly as one‐stage procedures (n = 39; 81.3%), to create different force vectors. Single or double innervated muscle transfers were utilized in 32 (66.7%) and 16 (33.3%) cases with additionally harvested skin paddles in 4 (8.3%) patients. The LTN was mostly anastomosed to the ipsilateral masseteric nerve (45.8%; n = 22) or to remaining facial nerve branches (37.5%; n = 18), while cross‐facial‐nerve‐grafting was rarely used (16.7%; n = 8). The SAFF as composite flap with different force vectors proved to be a good candidate for immediate dynamic facial reanimation after any midface defects.
Maternal rodent exposure to di‐(2‐ethylhexyl) phthalate decreases muscle mass in the offspring by increasing myostatin
Authors: Li Fengju , Luo Ting , Rong Honghui , Lu Lu , Zhang Ling , Zheng Chuanfeng , Yi Dali , Peng Yi , Lei Enyu , Xiong Xiaotao , Wang Fengchao , Garcia Jose M. , Chen Ji‐an 
Published: October 2022

AbstractBackgroundDi‐(2‐ethylhexyl) phthalate (DEHP) and its metabolites can cross the placenta and may cause birth defects and developmental disorders. However, whether maternal DEHP exposure affects skeletal muscle development in the offspring and the pathways involved are unknown. This study investigated the effects of maternal DEHP exposure and the contribution of myostatin (MSTN) to skeletal muscle development in the offspring.MethodsPregnant wild‐type and muscle‐specific myostatin knockout (MSTN KO) C57BL/6 mice were randomized to receive vehicle (corn oil) or 250 mg/kg DEHP by gavage every other day until their pups were weaned (postnatal day 21 [PND21]). Body weights of the offspring mice were measured longitudinally, and their hindleg muscles were harvested at PD21. Also, C2C12 cells were treated with mono‐2‐ethylhexyl phthalate (MEHP), the primary metabolite of DEHP, and proteolysis, protein synthesis, and myogenesis markers were measured. The contribution of myostatin to maternal DEHP exposure‐induced muscle wasting in the offspring was determined.ResultsMaternal DEHP exposure reduced body weight growth, myofibre size, and muscle mass in the offspring compared to controls (Quad: 2.70 ± 0.1 vs. 3.38 ± 0.23, Gastroc: 2.29 ± 0.09 vs. 2.81 ± 0.14, Tibialis: 1.01 ± 0.07 vs. 1.25 ± 0.11, mg/tibial length in mm, all P < 0.01, n = 35). Maternal DEHP exposure significantly increased Myostatin expression (2.45 ± 0.41 vs. 0.03 ± 0.00 DEHP vs. controls, P < 0.01, n = 5), Atrogin‐1(2.68 ± 0.65 vs. 0.63 ± 0.01, P < 0.05, n = 5), MuRF1 (1.56 ± 0.51 vs. 0.31 ± 0.01, P < 0.05, n = 5), and Smad2/3 phosphorylation (4.12 ± 0.35 vs. 0.49 ± 0.18, P < 0.05), and decreased MyoD (0.27 ± 0.01 vs. 1.52 ± 0.01, P < 0.05, n = 5), Myogenin (0.25 ± 0.03 vs. 1.95 ± 0.56, P < 0.05, n = 5), and AKT phosphorylation (4.12 ± 0.35 vs. 1.00 ± 0.06, P < 0.05, n = 5), in skeletal muscle of the offspring in MSTNflox/flox, but not in MSTN KO mice. Maternal DEHP exposure resulted in up‐regulation of CCAAT/enhancer‐binding protein δ (C/EBPδ, 4.12 ± 0.35 vs. 1.00 ± 0.19, P < 0.05, n = 5) in skeletal muscle of the offspring in MSTNflox/flox and MSTN KO mice (4.12 ± 0.35 vs. 4.35 ± 0.28, P > 0.05, n = 5). In vitro, C/EBPδ silencing abrogated the MEHP‐induced increases in Myostatin, MuRF‐1, and Atrogin‐1 and decreases in MyoD and Myogenin expression.ConclusionsMaternal DEHP exposure impairs skeletal muscle development in the offspring by enhancing the C/EBPδ‐myostatin pathway in mice.
A difficult‐to‐diagnose case of Borrmann type IV gastric cancer with marked transverse colon stenosis
Authors: Natsui Kazuki , Maruyama Masaki , Terai Shuji 
Published: October 2022

AbstractWe report a difficult‐to‐diagnose case of Borrmann type IV gastric cancer with poor typical findings and marked colonic stenosis in a 47‐year‐old man and present a literature review.
Does global value chain participation boost high technology exports?
Authors: Altun Abdullah , Avsar Ilker Ibrahim , Turan Taner , Yanikkaya Halit 
Published: October 2022

AbstractThis study examines the role of global value chain (GVC) participation in high technology exports using data over 120 countries during the 1995–2019 period. Our results suggest that GVC participation matters for high‐tech exports. While GVC participation with higher income countries is significantly associated with high‐tech exports, GVC participation with lower income countries has no effect. However, regardless of the origin countries, high‐tech GVC participation raises high‐tech exports. Moreover, GVC participation has a positive impact on high‐tech exports to lower income countries. Finally, we present evidence that the determinants of high‐tech exports vary by the income level of destination countries.