bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of pediatric acute-onset neuropsychiatric syndrome (PANS) in children and adolescents with eating disorders
Authors: Aman Marya , Coelho Jennifer S. , Lin Boyee , Lu Cynthia , Westwell-Roper Clara , Best John R. , Stewart S. Evelyn 
Published: December 2022

Abstract
Background
Pediatric obsessive–compulsive disorder (OCD) and eating disorder symptoms frequently overlap, clouding diagnostic certainty and hypothesized etiologic factors. Pediatric acute-onset neuropsychiatric syndrome (PANS) is defined by abrupt emergence of core obsessive–compulsive behaviours and/or food restriction with concurrent, ancillary cognitive and behavioral symptoms. Inflammatory and immune processes have putative roles in both PANS and a related described condition with cardinal obsessive–compulsive or tic symptoms, known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). While prevalence of PANS and PANDAS has been examined in tic, movement disorder and OCD populations, this has not yet been systematically examined in a pediatric eating disorder sample.

Objectives
To identify the lifetime prevalence of those meeting PANS and/or PANDAS criteria within a pediatric eating disorder cohort.

Methods
Convenience sampling method was utilized to select consecutive youth (ages 8–18-years) presenting to an interdisciplinary pediatric eating disorder subspecialty program with a confirmed eating disorder and completed parent-report PANS/PANDAS questionnaire (n = 100). A parent-reported measure was used to establish lifetime prevalence rates for PANS and PANDAS. Descriptive and exploratory comparative analyses were conducted between PANS and non-PANS groups. Continuous measures were analyzed using two-tailed independent sample t-tests and categorical measures were analyzed using two-tailed Fisher’s exact tests.

Results
Among participants, 52% (n = 52) met PANS criteria and 0% (n = 0) met PANDAS diagnostic criteria. Core, abrupt-onset PANS symptoms included both food restriction and obsessive–compulsive symptoms in 63.5% (n = 33), food restriction only in 25% (n = 13), and obsessive–compulsive symptoms only in 11.5% (n = 6) of participants. In comparison to those who did not meet PANS criteria, those in the PANS subgroup were less likely to be male and more commonly prescribed a selective serotonin reuptake inhibitor medication. Significant group differences did not emerge for onset age, body mass index, eating disorder type or comorbid psychiatric/medical/autoimmune illness.

Conclusion
Lifetime prevalence of symptoms in keeping with PANS diagnostic criteria within a pediatric eating disorder cohort was notably higher than that previously reported in OCD or tic disorder cohorts. The overlap between starvation effects and ancillary PANS symptoms may challenge the practical utility of this putative syndrome within the eating disorder population.
The impact of breast cancer on social cognition in female Colombian patients
Authors: Palacio Nicole , Romero Daniela Nicole , Bernal Andrés Mateo , González-Rodríguez Daniela , Solarte-Bothe Daniel , del Pilar García María , Murillo Raúl , Santamaría-García Hernando , Báez Sandra 
Published: December 2022

Abstract
Background
The high prevalence of female breast cancer is a global health concern. Breast cancer and its treatments have been associated with impairments in general cognition, as well as structural and functional brain changes. Considering the social challenges that some of these patients face, it is important to understand the socio-emotional effects of breast cancer as well. Nevertheless, the impact of breast cancer on social cognition has remained underexplored. The objective of this study was to assess social cognition domains and other relevant cognitive and emotional variables (executive functions, anxiety, or depression) in females with breast cancer.

Methods
The participants were 29 female patients diagnosed with breast cancer and 29 female healthy controls. We assessed emotion recognition, theory of mind, empathy, and moral emotions. We also included measures of general cognitive functioning, quality of life, anxiety, and depression. Linear multiple regressions were performed to assess whether the group (patients or controls), GAD-7 scores, emotional and social subscales of EORTC QLQ-C30, and IFS scores predicted the social cognition variables (EET, RMET, MSAT).

Results
Patients with breast cancer showed impairments in emotion recognition and in affective theory of mind. In addition, patients had lower scores in some executive functions. Only theory of mind between group differences remained significant after Bonferroni correction. Emotion recognition was associated with executive functioning, but anxiety levels were not a significant predictor of the changes in social cognition.

Conclusions
Social cognition impairments, especially in theory of mind, may be present in breast cancer, which can be relevant to understanding the social challenges that these patients encounter. This could indicate the need for therapeutic interventions to preserve social cognition skills in patients with breast cancer.
Washover deposits related to tsunami and storm surge along the north coast of the Shimokita Peninsula in northern Japan
Authors: Ishimura Daisuke , Ishizawa Takashi , Yamada Masaki , Aoki Kaori , Sato Kai 
Published: December 2022

AbstractA decade after the 2011 Tohoku-oki earthquake (Mw 9.0), geological surveys were conducted at multiple sites along the Pacific Coast of the tsunami-inundated Tohoku region in Japan, providing thousands of years of tsunami history. However, the challenges of correlation between historical records and geological tsunami deposits and identifying sources of historical and paleotsunamis have newly surfaced. Particularly the simultaneity and source of the 1611 Keicho tsunami in the Tohoku region and the seventeenth-century tsunami in the Hokkaido region are problematic. To solve such major issues, we conducted a tsunami-deposit survey at Sekinehama on the north coast of Shimokita Peninsula, near the junction of the Japan and Kuril trenches. We performed nondestructive analyses (X-ray computed tomography and micro-X-ray-fluorescence core scanning), grain-size analysis, tephra analysis, and radiocarbon dating of sediments from two coastal outcrops and inland drill cores. We identified five tsunami deposits (TD1–TD5) during the last 6 kyr and correlated them at a 200–400 m distance from the coast. They also correlate with previously identified tsunami deposits around the Shimokita Peninsula. From our study on tsunami deposits, we found other washover deposits in the coastal outcrops that are not represented in the inland cores. These indicate minor washover events related to small tsunamis and infrequent storm surges. The modeled age of the latest tsunami deposit is 500–300 cal yr BP (1450–1650 cal CE). This either correlates with two known tsunamis (the 1611 Keicho tsunami and another seventeenth-century tsunami) or is a previously unknown tsunami that occurred in the fifteenth–seventeenth centuries. If the latest tsunami deposit is to be accurately correlated with tsunami deposits previously identified within a 50-km distance from the study site, we need to consider an unknown fifteenth-century tsunami. Our investigation yields insights regarding the tsunami source in the vicinity of the junction of the Japan and Kuril trenches.
Quantification and dosimetry of small volumes including associated uncertainty estimation
Authors: Carnegie-Peake Lily , Taprogge Jan , Murray Iain , Flux Glenn D. , Gear Jonathan 
Published: December 2022

Abstract
Background
Accurate quantification of radioactivity in a source of interest relies on accurate registration between SPECT and anatomical images, and appropriate correction of partial volume effects (PVEs). For small volumes, exact registration between the two imaging modalities and recovery factors used to correct for PVE are unreliable. There is currently no guidance relating to quantification or the associated uncertainty estimation for small volumes.

Material and methods
A method for quantification of small sources of interest is proposed, which uses multiple oversized volumes of interest. The method was applied to three Na[131I]I activity distributions where a Na[131I]I capsule was situated within a cylindrical phantom containing either zero background, uniform background or non-uniform background and to a scenario with small lesions placed in an anthropomorphic phantom. The Na[131I]I capsule and lesions were quantified using the proposed method and compared with measurements made using two alternative quantification methods. The proposed method was also applied to assess the absorbed dose delivered to a bone metastasis following [131I]mIBG therapy for neuroblastoma including the associated uncertainty estimation.

Results
The method is accurate across a range of activities and in varied radioactivity distributions. Median percentage errors using the proposed method in no background, uniform backgrounds and non-uniform backgrounds were − 0.4%, − 0.3% and 1.7% with median associated uncertainties of 1.4%, 1.4% and 1.6%, respectively. The technique is more accurate and robust when compared to currently available alternative methods.

Conclusions
The proposed method provides a reliable and accurate method for quantification of sources of interest, which are less than three times the spatial resolution of the imaging system. The method may be of use in absorbed dose calculation in cases of bone metastasis, lung metastasis or thyroid remnants.
Immersive virtual reality fitness games for enhancement of recovery after colorectal surgery: study protocol for a randomised pilot trial
Authors: Wolf Sebastian , Zanker Johannes , Sommer Florian , Vlasenko Dmytro , Pinto David R. M. , Hoffmann Michael , Anthuber Matthias , Schrempf Matthias C. 
Published: December 2022

Abstract
Background
Physical inactivity after surgery is an important risk factor for postoperative complications. Compared to conventional physiotherapy, activity-promoting video games are often more motivating and engaging for patients with physical impairments. This effect could be enhanced by immersive virtual reality (VR) applications that visually, aurally and haptically simulate a virtual environment and provide a more interactive experience. The use of VR-based fitness games in the early postoperative phase could contribute to improved mobilisation and have beneficial psychological effects. Currently, there is no data on the use of VR-based fitness games in the early postoperative period after colorectal surgery.

Methods
This pilot trial features a single-centre, randomised, two-arm study design with a 1:1 allocation. Patients undergoing elective abdominal surgery for colorectal cancer or liver metastases of colorectal cancer will be recruited. Participants will be randomly assigned to an intervention group or a control group. Patients randomised to the intervention group will perform immersive virtual reality-based fitness exercises during their postoperative hospital stay. Feasibility and clinical outcomes will be assessed.

Discussion
Early mobilisation after surgery is crucial for reducing many postoperative complications. VR-based interventions are easy to use and often inexpensive, especially compared to interventions that require more medical staff and equipment. VR-based interventions could serve as an alternative or complement to regular physiotherapy and enhance mobilisation after surgery. The proposed pilot study will be the first step to evaluate the feasibility of VR-based interventions in the perioperative period, with the aim of improving the postoperative rehabilitation of cancer patients.

Trial registration
The trial has been registered in the German Clinical Trials Register (DRKS) Nr. DRKS00024888, on April 13, 2021, WHO Universal Trial Number (UTN) U1111-1261–5968.
Biomimetic hydrogel blanket for conserving and recovering intrinsic cell properties
Authors: Um Seung-Hoon , Seo Youngmin , Seo Hyunseon , Lee Kyungwoo , Park Sun Hwa , Jeon Jung Ho , Lim Jung Yeon , Ok Myoung-Ryul , Kim Yu-Chan , Kim Hyunjung , Cheon Cheol-Hong , Han Hyung-Seop , Edwards James R. , Kim Sung Won , Jeon Hojeong 
Published: December 2022

Abstract

Background
Cells in the human body experience different growth environments and conditions, such as compressive pressure and oxygen concentrations, depending on the type and location of the tissue. Thus, a culture device that emulates the environment inside the body is required to study cells outside the body.

Methods
A blanket-type cell culture device (Direct Contact Pressing: DCP) was fabricated with an alginate-based hydrogel. Changes in cell morphology due to DCP pressure were observed using a phase contrast microscope. The changes in the oxygen permeability and pressure according to the hydrogel concentration of DCP were analyzed. To compare the effects of DCP with normal or artificial hypoxic cultures, cells were divided based on the culture technique: normal culture, DCP culture device, and artificial hypoxic environment. Changes in phenotype, genes, and glycosaminoglycan amounts according to each environment were evaluated. Based on this, the mechanism of each culture environment on the intrinsic properties of conserving chondrocytes was suggested.

Results
Chondrocytes live under pressure from the surrounding collagen tissue and experience a hypoxic environment because collagen inhibits oxygen permeability. By culturing the chondrocytes in a DCP environment, the capability of DCP to produce a low-oxygen and physical pressure environment was verified. When human primary chondrocytes, which require pressure and a low-oxygen environment during culture to maintain their innate properties, were cultured using the hydrogel blanket, the original shapes and properties of the chondrocytes were maintained. The intrinsic properties could be recovered even in aged cells that had lost their original cell properties.

Conclusions
A DCP culture method using a biomimetic hydrogel blanket provides cells with an adjustable physical pressure and a low-oxygen environment. Through this technique, we could maintain the original cellular phenotypes and intrinsic properties of human primary chondrocytes. The results of this study can be applied to other cells that require special pressure and oxygen concentration control to maintain their intrinsic properties. Additionally, this technique has the potential to be applied to the re-differentiation of cells that have lost their original properties.
A demand side controller of electrolytic aluminum industrial microgrids considering wind power fluctuations
Authors: Ding Xin , Xu Jian , Sun Yuanzhang , Liao Siyang , Zheng Jingwen 
Published: December 2022

AbstractDirect wind power purchase for large industrial users is a meaningful way to improve wind power consumption and decrease industrial production costs. Short-term wind power fluctuations may lead to large-scale wind power curtailment problems. To promote use of wind energy, a demand side control method is proposed based on output regulator theory for a grid-connected industrial microgrid with electrolytic aluminum loads to continuously track and respond to wind power fluctuations. The control model of the EALs and the dominant frequencies of the wind power fluctuation signals are analyzed and incorporated into the demand side control plant. The feedback control signals with active power deviations on the tie-line are used to design the demand side controller. Simulations are conducted for an actual industrial microgrid to validate the feasibility and effectiveness of the proposed method. The results demonstrate that the proposed controller based on output regulator theory is able to effectively track wind power fluctuations.
Lymphopenia during 177Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report
Authors: Boughdad Sarah , Da Mota Michael , Mendes De Carvalho Mélanie , Firsova Maria , Prior John O. , Schaefer Niklaus 
Published: December 2022

AbstractWe report the case of a 72-year-old woman who presented with tuberculous arthritis during the setting of 177Lu-DOTATATE therapy for a grade-2 neuro-endocrine pancreatic tumor with liver metastases. We hypothesized that this recurrence might have been related to the occurrence of lymphopenia, which is common during PRRT. Indeed, though lymphopenia is frequently dismissed, it could lead to the development of opportunistic diseases and its severity should be examined, especially in case of abnormal clinical symptoms.
Long loop technique with bifemoral access as salvage technique for repositioning of dislodged port catheters
Authors: Van den Bosch Vincent , De Beukelaer Frédéric , Isfort Peter , Keil Sebastian , Kuhl Christiane K. , Bruners Philipp , Pedersoli Federico 
Published: December 2022

Abstract
Background
Repositioning of dislocated port systems’ catheters is usually performed with a pigtail catheter and/or a goose snare. In case of an inaccessible port catheter tip due to thrombosis, this classic approach may be not successful. For these cases, we describe a long loop bailout technique with bifemoral access.

Technique
Via a right transfemoral access, a first attempt to reposition the dislodged port catheter using pigtail catheter and goose snare was performed. After an unsuccessful attempt and delineation of thrombosis of the catheter tip, the contralateral femoral vein was subsequently punctured and a sheath was placed. Through both vascular sheaths, pigtail catheter and goose wire were advanced distally to the catheter. The guidewire in the pigtail catheter was snared, thus creating a “Long loop” configuration. Pulling down both catheters simultaneously with improved stability allowed to detach the catheter tip from the vessel wall and replacement into the superior vena cava was possible. Refinement of catheter tip position was done using the goose snare. This technique was applied on 5 patients with dislodged port catheters in the jugular vein (2/5), the innominate vein (1/5), the subclavian vein (1/5) and the azygos vein (1/5) with a technical success of 100%. No complications were observed.

Conclusion
The Long loop technique can be used as salvage approach to reposition a dislodged catheter in case of failure with pigtail catheter and goose snare.
The Stieda process of the talus: the anatomical knowledge and clinical significance of an overlooked protrusion
Authors: Ogut Eren 
Published: December 2022

Abstract
Background
The Stieda process (SP) is an extended lateral tubercle of the posterior process of the talus. Although there are different classifications for SP in the literature, it is essential to know the differential diagnosis of SP from fractures and accessory ossicles. This review aims to classify the SP and to guide the formation, prevalence, etiopathology, symptoms, differential diagnosis, and treatment.

Main body of the abstract
The authors conducted a literature review that lasted up to September 2022 and used the databases PubMed, Web of Science, and Google Scholar to explore the SP of the talus in all of its aspects. Out of 3802 publications, only 34 could be included, and most of them were studies on posterior ankle impingement syndrome (PAIS). The occurrence, prevalence, etiopathology, clinical significance, symptoms, differential diagnosis, and treatment methods of SP were investigated based on the literature. SP is formed by the fusion of a secondary ossification center at the posterolateral side of the talus with an incidence of 12–36.5%. It is frequently observed in males. It causes reduced plantar flexion, impairment in the inversion of the foot, pain, and swelling in the posterior ankle joint, PAIS, and SP fractures after trauma.

Short conclusion
SP can be diagnosed by lateral ankle radiography or MRI in patients complaining of PAIS. The initial treatment of the SP should include reducing inflammation, swelling, pain, and limiting activities. If neither modality affects the patient, surgical treatment will be performed, and SP will be resected until the impingement disappears.
Gut microbiota of homing pigeons shows summer–winter variation under constant diet indicating a substantial effect of temperature
Authors: Dietz Maurine W. , Matson Kevin D. , Versteegh Maaike A. , van der Velde Marco , Parmentier Henk K. , Arts Joop. A. J. , Salles Joana F. , Tieleman B. Irene 
Published: December 2022

Abstract
Background
Gut microbiotas play a pivotal role in host physiology and behaviour, and may affect host life-history traits such as seasonal variation in host phenotypic state. Generally, seasonal gut microbiota variation is attributed to seasonal diet variation. However, seasonal temperature and day length variation may also drive gut microbiota variation. We investigated summer–winter differences in the gut bacterial community (GBC) in 14 homing pigeons living outdoors under a constant diet by collecting cloacal swabs in both seasons during two years. Because temperature effects may be mediated by host metabolism, we determined basal metabolic rate (BMR) and body mass. Immune competence is influenced by day length and has a close relationship with the GBC, and it may thus be a link between day length and gut microbiota. Therefore, we measured seven innate immune indices. We expected the GBC to show summer–winter differences and to correlate with metabolism and immune indices.

Results
BMR, body mass, and two immune indices varied seasonally, other host factors did not. The GBC showed differences between seasons and sexes, and correlated with metabolism and immune indices. The most abundant genus (Lachnoclostridium 12, 12%) and associated higher taxa, were more abundant in winter, though not significantly at the phylum level, Firmicutes. Bacteroidetes were more abundant in summer. The Firmicutes:Bacteroidetes ratio tended to be higher in winter. The KEGG ortholog functions for fatty acid biosynthesis and linoleic acid metabolism (PICRUSt2) had increased abundances in winter.

Conclusions
The GBC of homing pigeons varied seasonally, even under a constant diet. The correlations between immune indices and the GBC did not involve consistently specific immune indices and included only one of the two immune indices that showed seasonal differences, suggesting that immune competence may be an unlikely link between day length and the GBC. The correlations between the GBC and metabolism indices, the higher Firmicutes:Bacteroidetes ratio in winter, and the resemblance of the summer–winter differences in the GBC with the general temperature effects on the GBC in the literature, suggest that temperature partly drove the summer–winter differences in the GBC in homing pigeons.