bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvothermal synthesis and characterization of monoclinic WO 3 nanoplatelets. Investigation of their photocatalytic performance
Authors: Chakib Alaoui , Mohamed Karmaoui , Elaziouti Abdelkader , Touati Wassila , Allah Imene Kaddi , Benhamed Amine , Bekka Ahmed 
Published: August 2022

Abstract
An original, facile way based on a non-aqueous sol–gel solvothermal process has been developed to synthesize 2D tungsten trioxide (WO3) nanoplatelets in one pot. The reaction between Tungstic acid (H2WO4) and 1-hexanol was a simple process, which resulted in the formation of highly crystalline metal oxide based on WO3 with an average size ranging between 30 and 50 nm, and with a correspondingly high surface area. The structural, morphological, functional group, optical qualities of the materials and the properties of the adsorption surfaces were all examined, and the degree of surface hydroxyls (– OH groups) has been examined. The products of the reaction were characterized by X-ray Powder Diffraction, Scanning Electron Microscopy, Transmission Electron Microscopy, Nitrogen adsorption, and pore-size distribution Brunauer-Emmett-Teller, Fourier Transform Infrared Spectroscopy and Nuclear Magnetic Resonance Spectroscopy techniques. which indicated the formation of di-hexyl ether as a result of the solvothermal reaction. The optical absorption, measured using UV–Vis Diffuse Reflectance Spectroscopy, revealed a narrow bandgap (Eg = 2.18 and 2.48 eV for WO3-24 and WO3-48, respectively) compared to that of for bulk WO3 (2.7 eV), attributable to oxygen vacancies. Upon increasing dwell time from 24 to 48 h, a blue-shift was observed, highlighting a quantum size effect. The as-prepared WO3 nanoplatelets displayed excellent photocatalytic performance for degrading Rhodamine B under visible light-emitting diode light with up 99 % degradation rate was achieved in 120 min. Thus, the enhanced Rhodamine B photodegradation in the presence WO3-24 along with H2O2 was assigned to the reactive oxygen species (ROS) such as ; OH and RhB *+ , involving in the strong synergistic effect between WO3 and H2O2, effectively separating of photocarriers and, as a consequence, boosting the photocatalytic efficiency.
Scalable training of graph convolutional neural networks for fast and accurate predictions of HOMO-LUMO gap in molecules
Authors: Choi Jong Youl , Zhang Pei , Mehta Kshitij , Blanchard Andrew , Pasini Massimiliano Lupo 
Published: August 2022

Abstract
Graph Convolutional Neural Network (GCNN) is a popular class of deep learning (DL) models in material science to predict material properties from the graph representation of molecular structures. Training an accurate and comprehensive GCNN surrogate for molecular design requires large-scale graph datasets and is usually a time-consuming process. Recent advances in GPUs and distributed computing open a path to reduce the computational cost for GCNN training effectively. However, efficient utilization of high performance computing (HPC) resources for training requires simultaneously optimizing large-scale data management and scalable stochastic batched optimization techniques. In this work, we focus on building GCNN models on HPC systems to predict material properties of millions of molecules. We use HydraGNN, our in-house library for large-scale GCNN training, leveraging distributed data parallelism in PyTorch. We use ADIOS, a high-performance data management framework for efficient storage and reading of large molecular graph data. We perform parallel training on two open-source large-scale graph datasets to build a GCNN predictor for an important quantum property known as the HOMO-LUMO gap. We measure the scalability, accuracy, and convergence of our approach on two DOE supercomputers: the Summit supercomputer at the Oak Ridge Leadership Computing Facility (OLCF) and the Perlmutter system at the National Energy Research Scientific Computing Center (NERSC). We present our experimental results with HydraGNN showing i) reduction of data loading time up to 4.2 times compared with a conventional method and ii) linear scaling performance for training up to 1,024 GPUs on both Summit and Perlmutter.
Gene expression in bumble bee larvae differs qualitatively between high and low concentration imidacloprid exposure levels
Authors: Martín-Blázquez Rubén , Calhoun Austin Charles , Sadd Ben Michael , Cameron Sydney Anne 
Published: August 2022

Abstract
Neonicotinoid pesticides negatively affect important bumble bee traits, even at sublethal concentrations. Phenotypic responses to sublethal concentrations of the neonicotinoid imidacloprid have been studied, largely at individual adult and colony levels. Yet little is known about concentration-specific responses in developing larvae, particularly at the transcriptomic level. We hypothesize that relatively high (7.0 ppb) and low (0.7 ppb) field-realistic imidacloprid concentrations cause qualitative differences in gene expression of bumble bee larvae. To examine this hypothesis, worker-fed Bombus impatiens larvae were provisioned with either high or low imidacloprid treated pollen and sugar water, or untreated control food. Subsequent larval gene expression analysis revealed 678 genes differentially expressed in both the high and low imidacloprid larvae relative to controls, including genes involved in mitochondrial activity, development, and DNA replication. A set of 755 genes were differentially expressed only in the high imidacloprid concentration-exposed larvae, including starvation response and cuticle genes. Lastly, 191 genes were differentially expressed only in low imidacloprid concentration-exposed larvae, including genes associated with neural development and cell growth. Our findings show varying consequences of different neonicotinoid exposure concentrations within field-realistic ranges, and that even low concentrations affect the expression of genes that are fundamental to bumble bee health and development.
Evaluating the Dark Sky Weather Forecast Data Over Florida and Georgia
Authors: Bayabil Haimanote K. , Teshome Fitsum T. , Wu Songzi , Yu Ziwen 
Published: August 2022

Abstract
The Dark Sky (DKS; © 2020 Apple Inc.) provides weather forecasts for most locations throughout the world. The objectives of this study were to 1) evaluate the accuracy of the DKS system in capturing selected weather parameters compared to observations at 124 weather stations in Florida and Georgia and 2) provide a strategy using machine learning to identify features that affect the accuracy of rainfall forecast. Daily forecast weather data were obtained using the DKS’ application programming interface (API). Data included daily total rainfall, minimum (Tmin) and maximum (Tmax) temperatures, daily average wind speed, dew point, and relative humidity (RH). The DKS system performed better in capturing forecasts of Tmin and Tmax, and dew point but its performances with rainfall, RH, and wind speed were poor. In addition, the DKS forecast system over-predicts rainfall events <5mm while under-predicting events >5mm. However, the DKS system was able to forecast the occurrence (yes/no) of rainfall events with a probability of detection (POD) values between 0.91 and 1.0. Machine learning model results showed that the accuracy of rainfall forecast was affected by changes in temperature after a rainfall event. The error of a next-day precipitation forecast was < 2.5 mm when post rainfall temperature drops by 5℃. Overall, results suggest that the DKS forecast system could be a reliable source of dichotomous (yes/no) rainfall forecasts, but its quantitative rainfall predictions were poor.
Quality of life and physical/psychosocial factors in children and adolescents with orthostatic intolerance
Authors: Shigeyasu Yoshie , Okada Ayumi , Fujii Chikako , Tanaka Chie , Sugihara Akiko , Horiuchi Makiko , Yorifuji Takashi , Tsukahara Hirokazu 
Published: August 2022

Abstract
Background: Orthostatic intolerance (OI) is common in children and adolescents, which negatively impacts their quality of life (QOL) due to physical symptoms that limit work, school, and daily activities. The purpose of this study is to explore the association of physical and psychosocial factors with QOL scores in children and adolescents with OI.Methods: A cross sectional observational study was conducted. The study participants included 95 Japanese pediatric patients of age 9–15 years who were diagnosed with OI from April 2010 to March 2020. The QOL scores and the QOL T-scores of children with OI assessed by the KINDL-R questionnaire at the initial visit were compared with conventional normative data. The associations of physical and psychosocial factors with the QOL T-scores were examined using multiple linear regression.Results: Pediatric patients with OI had significantly lower QOL scores than healthy children in both elementary (50.7 ± 13.5 vs. 67.9 ± 13.4, p < 0.001) and junior high schools (51.8 ± 14.6 vs. 61.3 ± 12.6, p < 0.001). This finding was observed in the physical, mental, self-esteem, friends, and school domains. Nonattendance [β = −5.0, 95% confidence interval (CI) = −9.8 to 0.4, p = 0.035] and poor relationship with school (β = −10.7, 95% CI = −15.3 to −6.4, p < 0.001) were significantly associated with impaired total QOL scores.Conclusions: These results suggest that the assessment of QOL, including both physical and psychosocial aspects, especially school factors, needs to be implemented earlier in children and adolescents with OI.
Analysis of maternal and child health indicators: the composite coverage index (CCI) used in Guinea from 2012 to 2018
Authors: CISSE Diao , TOURE Almamy Amara , DIALLO Abdourahamane , GOUNGOUNGA Juste Aristite , KADIO Jean Jaques Olivier , BARRY Ibrahima , BERETE Souleymane , MAGASSOUBA Aboubacar Sidiki , HAROUNA Souleymane Hassane , CAMARA Alseny Yarie , SYLLA Younoussa , CISSE Kola , SIDIBE Maïmouna , TOURE Abdoulaye , DELAMOU Alexandre 
Published: August 2022

Abstract
Introduction The composite coverage index (CCI) is the weighted average coverage of eight preventive and curative interventions received along the maternal and child care continuum. We analysed maternally and child health indicators using CCI.Methods We performed a secondary analysis of demographic and health surveys (DHS) focused on women aged 15 to 49 and children aged 1 to 4. The CCI is optimal if the weighted proportion of interventions is less than 50%; otherwise, it is partial. We identified the factors associated with CCI using the following statistics: the Wilcoxon rank-sum test for complex survey samples, the chi-squared tests of Rao & Scott’s second-order correction, and the spatial autocorrelation statistic and the multivariate logistic regression.Results The optimal coverage of the ICC has increased from 43% in 2012 to 61% in 2018. In multivariate analysis, in 2012: the poor had a lower probability of having an optimal CCI than the richest; OR=0.11 [95% CI; 0.07, 0.18]. Those who had done four antenatal care visits (ANC) were 2.78 times more likely to have an optimal CCI than those with less OR=2.78 [95% CI;2.24, 3.45]. In 2018: the poor had a lower probability of having an optimal CCI than the richest OR=0.27 [95% CI; 0.19, 0.38]. Women who planned their pregnancies were 28% more likely to have an optimal CCI than those who had not planned OR= 1.28 [95% CI;1.05, 1.56]. Finally, women with more than 4 ANC were 2.43 times more likely to have an optimal CCI than those with the least OR = 2.43 [95% CI; 2.03, 2.90]. The spatial analysis reveals significant disparities with an aggregation of high partial ICC in Labé between 2012 and 2018.ConclusionThis study showed an increase in CCI between 2012 and 2018. Policies should improve access to care and information for poor women. Besides, strengthening ANC visits and reducing regional inequalities will increase optimal CCI.
The dynamics and function of stressosome proteins in Listeria monocytogenes
Authors: Tran Buu Minh , Linnik Dmitrii , Punter Michiel , Śmigiel Wojciech , Mantovanelli Luca , Iyer Aditya , O'Byrne Conor , Abee Tjakko , Johansson Jorgen , Poolman Bert 
Published: August 2022

Abstract
The human pathogen Listeria monocytogenes is a model microorganism in infection biology. The organism can transform from a saprophyte to an intracellular pathogen and cope with severe environmental challenges, for which the high molecular weight stressosome complex acts as the sensing hub in a complex signal transduction pathway. Yet, little is known of the dynamics, function and localization of the proteins involved in the stress response. We have now determined the dynamics and functional roles of cytosolic, membrane-bound and clustered components of the stressosome complex, using photo-activated localization microscopy (PALM) combined with single-particle tracking (SPT) and single-molecule displacement mapping (SMdM) and supported by physiological studies. We analyzed the stressosome protein RsbR1 and the related blue-light receptor protein RsbL. We find that RsbR1 diffusion is consistently slow, and the protein interacts with the plasma membrane via Prli42. The membrane-bound state of RsbR1 is not required for stress sensing. RsbL diffuses freely in the cytoplasm but associates with the stressosome complex upon exposure to light. The association of RsbL with the stressosome complex is stable and independent of the presence of Prli42. Taken together, our work provides a comprehensive view of the spatial organization and intracellular dynamics of the stressosome proteins in L. monocytogenes, which paves the way towards uncovering the stress sensing mechanism of this signal transduction pathway.
Attenuated post-movement beta rebound reflects psychomotor alterations in major depressive disorder during a simple visuomotor task: a MEG study
Authors: Xia Yi , Hua Lingling , Dai Zhongpeng , Han Yinglin , Du Yishan , Zhao Shuai , Zhou Hongliang , Wang Xiaoqin , Yan Rui , Wang Xumiao , Zou HaoWen , Sun Hao , Huang YingHong , Yao ZhiJian , Lu Qing 
Published: August 2022

Abstract
Background
Psychomotor alterations are a common symptom in patients with major depressive disorder (MDD). The primary motor cortex (M1) plays a vital role in the mechanism of psychomotor alterations. Post-movement beta rebound (PMBR) in the sensorimotor cortex is abnormal in patients with motor abnormalities. However, the changes in M1 beta rebound in patients with MDD remain unclear. This study aimed to primarily explore the relationship between psychomotor alterations and PMBR in MDD.
Methods
132 subjects were enrolled in the study, comprising 65 healthy controls (HCs) and 67 MDD patients. All participants performed a simple right-hand visuomotor task during MEG scanning. PMBR was measured in the left M1 at the source reconstruction level with the time-frequency analysis method. Retardation factor scores and neurocognitive test performance, including the Digit Symbol Substitution Test (DSST), the Making Test Part A (TMT-A), and the Verbal Fluency Test (VFT), were used to measure psychomotor functions. Pearson correlation analyses were used to assess relationships between PMBR and psychomotor alterations in MDD.
Results
The MDD group showed worse neurocognitive performance than the HC group in all three neurocognitive tests. The PMBR was diminished in patients with MDD compared to HCs. In a group of MDD patients, the reduced PMBR was negatively correlated with retardation factor scores. Further, there was a positive correlation between the PMBR and DSST scores. PMBR is negatively associated with the TMT-A scores.
Conclusion
Our findings suggested that the attenuated PMBR in M1 could illustrate the psychomotor disturbance in MDD, possibly contributing to clinical psychomotor symptoms and deficits of cognitive functions.
Is better early closure compared to late closure of temporary ileostomy in rectal cancer? A randomized controlled trial study
Authors: Ahmadi-Amoli Hadi , Rahimi Mohsen , Abedi-kichi Raziyeh , Ebrahimian Nazli , Hajebi Reza , Rahimpour Ehsan 
Published: August 2022

Abstract
Purpose
A temporary loop ileostomy is one of the most common methods for the prevention of anastomotic leakage in rectal cancer patients who underwent low anterior resection. However, the optimal timing of loop ileostomy reversal remains unknown. The main purpose of this study is to assess the suitable time for a reversal of temporary loop ileostomy in rectal cancer patients.
Methods
We conducted a prospective, randomized trial at Sina Hospital, Tehran, Iran from 2020 to 2021 to determine the appropriate time for closure of temporary loop ileostomy in rectal cancer patients who underwent low anterior resection.
Results
The results of this prospective randomized controlled trial are as shown: significantly difference in body mass index, the time interval between creation and closure of stoma, and distance from last chemotherapy. No significant difference was found between the two groups in terms of complications based on the Clavien-Dindo classification. As well as, there is no significant difference in perioperative outcomes, such as blood loss, operative time, re-admission, and re-operation. Also, statistically significant differences had reported between patients' quality of life and LARS score.
Conclusion
In summary, it seems that early closure of ileostomy is generally effective and safe in reducing the risk of complications and improving quality of life in patients with rectal cancer following low anterior resection and chemotherapy (neoadjuvant and adjuvant).
Trial registration number and date of registration:
IRCT20201113049373N1 (January 2,2021)
Exosomes from adipose-derived stem cells activate sebocytes through the PI3K/AKT/SREBP-1 pathway to accelerate wound healing
Authors: Zhang Yingbo , Zhang Miaobo , Liu Chang , Qin Youyou , Liu ying , Xu zidi , xiao zhibo 
Published: August 2022

Abstract

Background: Sebaceous glands (SGs) are epidermal appendages that are important constituents of fully functional skin. The reconstruction of SGs is an integral part of wound healing. Exosomes from adipose-derived stem cells (ADSC-EXO) accelerate wound healing by promoting the migration and proliferation of fibroblasts and keratinocytes. However, the effects of ADSC-EXO on SGs are largely unknown. Methods: In this study, three-dimensional scaffolds of gelatin methacrylate (GelMA) hydrogel loaded with the human SZ95 sebocytes were used as an in vitro model of human SGs. The effects of ADSC-EXO on SZ95 cell proliferation and migration were evaluated with the EdU colorimetric immunohistochemistry assay and the scratch and Transwell assays. The levels of phosphorylated Akt, Akt, mammalian target of rapamycin, sterol regulatory-element binding protein (SREBP), and perilipin-1 (PLIN-1) were detected with immunofluorescence, quantitative PCR, and western blot analysis. Lipogenesis and lipolysis were assessed with Oil Red O and Nile red staining. Full-thickness skin wounds in BALB/c nude mice were treated with GelMA hydrogel loaded with SZ95 sebocytes alone or in combination with ADSC-EXO. Histopathological assessments of the wound tissues were performed with hematoxylin and eosin, Masson Trichrome staining and Immunohistochemical staining. Results: The results showed that ADSC-EXO upregulated Akt, enhanced SZ95 cell proliferation and migration, and inhibited apoptosis, and these effects of ADSC-EXO were blocked by the phosphoinositide 3-kinase (PI3K)/Akt inhibitor LY294002. ADSC-EXO also regulated SREBP and PLIN-1 through the PI3K/Akt pathway in an environment-dependent manner, and enhanced lipogenesis under normoxia but triggered lipolysis under hypoxia. In BALB/c mice, Oil red staining on day 14 post-treatment showing ADSC-EXO group had a lower total lipid content than control. More importantly, ADSC-EXO accelerated SZ95 sebocyte-assisted wound healing and reduced scar formation. Conclusions: These in vitro and in vivo results supported that ADSC-EXO can promote the regeneration of fully functional scarless skin after injury through the PI3K/Akt-dependent activation of sebocytes.
Effects of PPARα pathway on hepatic lipid metabolism in non-alcoholic fatty liver disease rat model
Authors: Du Tingwan , Xiang Lian , Zhang Jingjing , Zhao Wenxin , Li Jialu , Cheng Lei , Yang Yi , Han Nan , Zhou Yong , Ma Ling 
Published: August 2022

Abstract
Background Non-alcoholic fatty liver disease (NAFLD) is a common hepatic metabolic disorder that is characterized by the dyshomeostasis of lipid metabolism. It is usually accompanied by insulin resistance and hyperlipidemia. Regulating lipid metabolism via the peroxisome proliferator-activated receptor alpha (PPARα) pathway in the liver could potentially constitute a new target for elucidating the pathology of NAFLD. Therefore, we aimed to explore the PPARα pathway in a high-fat diet (HFD)-induced NAFLD rat model by non-competitive inhibitor MK886. Method Male Wistar rats were randomly divided into control (CON), HFD, HFD + MK 886 groups. After 14 weeks of intervention, body weight, energy intake, liver weight, serum biochemical markers, histology, morphology, and protein expression of PPARα, CPT1A, CD36, FABP1 in the liver were detected. Results Inhibiting PPARα by MK886 significantly reduced body weight; it improved hepatic function and serum lipid parameters. Furthermore, MK886 ameliorated hepatic steatosis by reducing the levels of CD36, PPARα and CPT1A. Conclusion The study indicates that inhibiting PPARα pathway could improve hepatic homeostasis by improving liver function and alleviating hepatic steatosis; this validated the role of PPARα and its downstream protein in hepatic fatty acid metabolism in NAFLD.
Numerical Simulation and Experimental Study on Electrolytic Grinding/Milling of Cemented Carbide
Authors: he yafeng , Xu Bo , Guo Hun , Zhou Xurong , Bai Jianhui 
Published: August 2022

Abstract
Cemented carbide is widely used in industrial production owing to its high hardness, high strength, and excellent wear and corrosion resistance. However, traditional machining is prone to machining defects such as cracking and burn. To address this problem, the cathode of a cemented carbide electrolytic grinding/milling tool was designed in this study. The distribution of the electric field of full-edge electrolytic grinding/milling was numerically simulated, and the variation in the electric field was obtained. A four-factor four-level orthogonal test of the side-edge electrolytic grinding/milling process was carried out, and the process parameters were optimized through range analysis. Based on the obtained results, the influence of feed speed on full-edge electrolytic grinding/milling was investigated. A cemented carbide electrolytic grinding/milling sample was fabricated and measured. The measurement results show that the surface is relatively flat and has a roughness of 0.389 μm. The obtained parameters meet the requirements of cemented carbide finishing.