bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal factors influencing mortality and morbidity two years after esophageal atresia primary repair: a single center retrospective study
Authors: Lefèvre Noémie Capucine , Gouez Morgane Le , Lesage Fabrice , Rousseau Véronique , Giuseppi Agnès , Abadie Véronique , Lapillonne Alexandre , Kermorvant-Duchemin Elsa 
Published: October 2022

Abstract
Purpose: Long-term digestive, respiratory and neurological morbidity is significant in children who have undergone surgery for esophageal atresia (EA), especially after staged repair for long-gap EA. Risk factors for morbidity after primary repair (non-long-gap populations) have been less documented. We investigated perinatal factors associated with unfavourable outcome in children two years after a primary esophageal anastomosis.
Methods: Single-center retrospective study, based on neonatal, surgical, and paediatric records of children born between December 1, 2002, and December 31, 2018, and followed up to age 2 years. The primary endpoint was unfavourable outcome at 2-years of age, defined by death or survival with severe respiratory, digestive, or neurologic morbidity. Univariate analyses followed by logistic regression analyses were performed to identify perinatal risk factors of unfavourable outcome among survivors at discharge.
Results: 150 neonates were included (mean birth weight 2520±718 g, associated malformations 61%); at age two, 45 (30%) had one or more severe morbidities, 11 had died during the neonatal stay and 2 after discharge (8.7% deaths). In multivariate analyses in the 139 survivors at discharge, duration of ventilatory support (invasive and non-invasive) for more than 8 days (OR 3.74; CI95%[1.68-8.60]; p=0.001) and achievement of full oral feeding before hospital discharge (OR 0.20; CI95%[0.06-0.56]; p=0.003) were independently associated with adverse outcome after adjustment for sex, preterm birth, associated heart defect, any surgical complication and the occurrence of more than one nosocomial infections during the neonatal stay.
Conclusions: Potentially modifiable neonatal factors are associated with 2-year unfavourable outcome after primary repair of EA.
A Hierarchical Porous towards High Performance CO2 capture and Congo Red Adsorption
Authors: Zhang Tingting , Li Jiaxin , Hua Yumeng , Dou Jiali , Wang Song , Chen Xuecheng , Li Sanxi 
Published: October 2022

Abstract
To achieve the goal of carbon neutrality, controlling CO2 emissions is a primary problem to be solved in the current environmental protection field. Eliminating the environmental pollution of dyes in industrial wastewater is also an urgent problem to be solved in the field of environmental protection. The adsorption technique is an effective way to deal with these two issues. Developing high-efficiency adsorbents to work in the adsorption field. In this work, a two steps carbonization method has been developed to prepare porous carbon by a carbonization procedure. The morphology and structure of the prepared porous carbon were investigated by SEM, XPS, XRD, and BET techniques. Selectively optimization, the as-prepared porous carbon materials exhibit a high specific surface area of 1476 m2 g− 1 and a high total pore volume of 0.951 cm3 g− 1. The PCMCA-900 shows the highest CO2 uptake of 7.67 mmol g− 1 at 0 ºC, stable cycling stability. Moreover, when PCMCA-900 was used as an adsorbent to remove Congo red in water, an adsorption capacity of 652.3 mg g− 1 was achieved. The above-mentioned results prove that potassium citrate derived porous carbon is a desirable candidate for excellent CO2 adsorption and Congo red in industrial wastewater.
Variability in and Formation of Homogeneous Regions of Precipitation Trends Across the Amazon River Basin, Determined From the Global Precipitation Climatology Centre - Gpcc
Authors: Filho David Figueiredo Ferreira , Pessoa Francisco Carlos Lira 
Published: October 2022

Abstract
Spatiotemporal patterns of precipitation are influenced by complex interactions between climate and land cover changes, such as deforestation, fires and droughts. The Amazon River Basin has local and global impacts in regard to the hydrological cycle; therefore, it is fundamental to understand how precipitation patterns and intensity are changing. The aim of this study was to analyze precipitation trends and form homogeneous regions of precipitation trends in the Amazon River Basin using data from the meteorological satellite Global Precipitation Climatology Centre (GPCC), applying nonparametric methods (Mann-Kendall, Spearman and Sen's slope) and fuzzy C-means to identify specific regions that are undergoing changes in hydrological patterns. The results show changes in the behavior of rainfall over time and in the intensity of the events. The statistics applied to form clusters resulted in 6 well-divided homogeneous groups, each with unique characteristics. Specifically, the central-southern areas of the basin showed negative precipitation trends (-1.17 mm/year) forming a homogeneous region (RH 1), while in the northern region, there was an increasing trend in precipitation (2.73 mm/year). In general, over the 37 years studied, the wet areas have tended to become wetter and the dry areas drier. Other homogeneous regions had their own results and unique characteristics, which are in agreement with other studies, such as those in Porto Velho, Rondônia, where this area had a diagonal pattern of precipitation decrease.
Complete genome sequence of mimosa mosaic virus, a new sobemovirus infecting Mimosa sensitiva L.
Authors: Kauffmann Caterynne Melo , Boari Alessandra de Jesus , Silva João Marcos Fagundes , Blawid Rosana , Nagata Tatsuya 
Published: October 2022

Abstract
A sobemovirus, tentatively named “mimosa mosaic virus” (MimMV), was found by high-throughput sequencing and isolated from the mimosa (Mimosa sensitiva L.) plant. The genome sequence was also confirmed by Sanger sequencing and comprises 4595 nucleotides. Phylogenetic analysis of the amino acid (aa) sequences of the P2b (from ORF2b) and the coat protein showed 52.7% and 31.8% aa sequence identities with those of blueberry shoestring virus, respectively. The complete genome sequence identity to MimMV with other sobemoviruses was less than 47%. These analyses suggest that MimMV is considered a new species of the genus Sobemovirus.
A single-institution retrospective series of SARs-Cov-2 infection in adult glioma patients
Authors: Lanman Tyler , Ruiz Amber N. , Nagpal Seema 
Published: October 2022

Abstract
Background
A subset of cancer patients is particularly vulnerable to SARS-Cov-2 infection; however, real-world outcomes-based data on primary central nervous system tumor patients is sparse. This retrospective series describes a cohort of adult glioma patients seen at Stanford Cancer Center between 1/1/2020 through 6/30/2022 who contracted SARS-Cov-2, which, to our knowledge, currently represents the largest single-institution comprehensive analysis of this patient population.
Methods
We performed a retrospective search of patients seen in the Stanford Neuro-Oncology clinic, identifying 29 cases of COVID-19 amongst glioma patients and extracted clinical data via individual chart review.
Results
Out of the 29 cases, 14 had high-grade glioma (grades 3 and 4) and 15 had low-grade (grades 1 and 2). At the time of COVID-19 diagnosis, 15 patients had been vaccinated against SARS-Cov-2, 8 patients were taking dexamethasone, and 8 were undergoing cancer-specific treatment. Obesity, prior tobacco use, and diabetes were the most common comorbidities. Cough, sore throat, and congestion were the most common symptoms. Five patients were admitted to the hospital and two received COVID-19-specific treatment. None of the patients died from Covid-related causes or complications.
Conclusion
Our data suggest that glioma patients seen at Stanford Cancer Center do not experience an exceptionally high COVID-19 infectivity, hospitalization, or mortality rate, especially when compared to other vulnerable populations such as lung cancer patients. High vaccination rates, adherence to COVID-19 guidelines, and low prevalence of comorbidities may have contributed to these results.
Multi-region sequencing depicts intratumor heterogeneity and clonal evolution in cervical cancer
Authors: Wang Chen , Bai Rui , Liu Yu , Wang Kun , Wang Yu , Yang Jian , Cai Haoyang , Yang Ping 
Published: October 2022

Abstract
Cervical cancer is a heterogeneous malignancy mainly caused by human papillomavirus (HPV). While a few studies have revealed heterogeneity of cervical cancer in chromosome levels, the correlation between genetic heterogeneity and HPV integration in cervical cancer remains unknown. Here, we applied multi-region whole-exome sequencing (WES) and HPV integration analysis to explore intratumor heterogeneity (ITH) in cervical cancer. We sequenced 20 tumor regions and 5 adjacent normal tissues from 5 cervical cancer patients, analysis based on somatic mutations and somatic copy number alterations (SCNAs) levels were performed. Variable heterogeneity was observed between the five patients with different tumor stages and HPV infection statuses. We found HPV integration has a positive effect on somatic mutation burden, but the relation to SCNAs remains unclear. Frequently mutated genes in cervical cancer were identified as trunk events, such as FBXW7, PIK3CA, FAT1 in somatic mutations and TP63, MECOM, PIK3CA, TBL1XR1 in SCNAs. New potential driver genes in cervical cancer were summarized including POU2F2, TCF7 and UBE2A. The SCNAs level has potential relation with tumor stage, and Signature 3 related to homologous recombination deficiency (HRD) may be the appropriate biomarker in advanced cervical cancer. Mutation signature analysis also revealed a potential pattern that APOBEC-associated signature occurs in early-stage and signatures associated with DNA damage repair arise at the later stage of cervical cancer evolution. In a conclusion, our study provides insights into the potential relationship between HPV infection and tumor heterogeneity. Those results enhanced our understanding of tumorigenesis and progression in cervical cancer.
Comprehensive Evaluation of Artifact Reduction and Tissue Recovery Effects of Metal Artifact Reduction Function Based on Full-Reference Metric
Authors: Jung Yunsub , Song You Seon , Lee In Sook , Rhee Seung Joon 
Published: October 2022

Abstract
For the comprehensive evaluation of metal artifact reduction (MAR) function, which is a post-processing technique that artifacts reduction caused by metal implants, not only the removal of metal artifacts but also the evaluation of the area restored by MAR is required. In this study, we have conducted the computed tomography (CT) scan both the evaluation image and the reference image at the same location of phantom for the full-reference based evaluation. The evaluation image and reference image were reconstructed into 24 image sets according to the tube potentials, image reconstruction method, and use of the MAR function. Images of two different positions were selected according to the distance from metal and material (bone, tissue) distribution, and bone and tissue were automatically segmented in all images. After Gaussian modeling of each segmented area, FWHM and centroid metrics were extracted. These two metrics were used to compare non-MAR image and MAR image compared to non-metal image. In addition, FWHMNM, FWHMM, CENTNM, and CENTM were calculated using the ratio of the evaluation image and the reference image, then MAR image and non-MAR image were compared. The occurrence of metal artifacts differed according to the distance from the metal and the tube potential. The effect of artifact reduction by the MAR function was confirmed in most regions except for some regions very close to the metal (p < .05). The tissue recovery effect through the application of the MAR function was different depending on the distance from the metal and the material, but the distribution of pixel values was maintained well even after the MAR function was applied (p < .05). Overall, the MAR function restored the original image information while reduction metal artifacts. However, in the regions of severe metal artifacts that are very close to the metal, the MAR function was limited.
Temporal Distribution Model and Occurrence Probability of M≥6.5 Earthquakes in North China Seismic Zone
Authors: Xu Weijin , Jian Wu , Gao Mengtan 
Published: October 2022

Abstract
The temporal distribution of earthquakes provides important basis for earthquake prediction and seismic hazard analysis. The relatively limited records of strong earthquakes have often made it difficult to study the temporal distribution models of regional strong earthquakes. However, there are hundreds of years of complete strong earthquake records in North China Seismic Zone, providing abundant basic data for studying temporal distribution models. Using the data of M ≥ 6.5 earthquakes in North China as inputs, this paper estimates the model parameters using the maximum likelihood method with exponential, Gamma, Weibull, Lognormal and Brownian passage time (BPT) distributions as target models. The optimal model for describing the temporal distribution of earthquakes is determined according to Akaike information criterion (AIC), determination coefficient R2 and Kolmogorov-Smirnov test (K-S test). The results show that Lognormal and BPT models perform better in describing the temporal distribution of strong earthquakes in North China. The mean recurrence periods of strong earthquakes (M ≥ 6.5) calculated based on these two models are 8.1 years and 13.2 years, respectively. In addition, we used the likelihood profile method to estimate the uncertainty of model parameters. For the BPT model, the mean and 95% confidence interval of recurrence interval µ is 13.2 (8.9–19.1) years, and the mean and 95% confidence interval of α is 1.29 (1.0-1.78). For the Lognormal model, the mean value and 95% confidence interval of v is 2.09 (1.68–2.49), the mean value exp (v) corresponding to earthquake recurrence interval is 8.1 (5.4–12.1) years. In this study, we also calculated the occurrence probability of M ≥ 6.5 earthquakes in North China Seismic Zone in the future, and found that the probability and 95% confidence interval in the next 10 years based on the BPT model is 35.3% (26.8%-44.9%); the mean value and 95% confidence interval of earthquake occurrence probability based on the Lognormal distribution is 35.4% (22.9%-49.7%); the mean probability and 95% confidence interval based on the Poisson model is 53.1% (41.1%-64%). The results of this study may provide important reference for temporal distribution model selection and earthquake recurrence period calculation in future seismic hazard analysis in North China.
In vivo Multi-Parameter Mapping of the Habenula using MRI
Authors: Milotta Giorgia , Green Isobel , Roiser Jonathan P , Callaghan Martina F. 
Published: October 2022

Abstract
The habenula is a small, epithalamic brain structure situated between the mediodorsal thalamus and the third ventricle, rostral to the posterior commissure. It plays an important role in the reward circuitry of the brain and is implicated in psychiatric conditions, such as depression. The importance of the habenula for human cognition and mental health make it a key structure of interest for neuroimaging studies However, relatively few studies have been conducted in humans to characterize its physical properties using magnetic resonance imaging as habenula visualization in vivo is challenging, primarily due to its subcortical location and small size. To date, microstructural characterization of the habenula has focused on QSM. In this work we complement this characterization with measures of longitudinal and effective transverse relaxation rates, proton density and magnetisation transfer saturation using a high-resolution quantitative multi-parametric mapping protocol at 3T, in a cohort of 26 healthy participants. The habenula was most clearly visualised on the R1 maps, with highest CNR for each participant. However, its boundaries were consistent across the different parameter maps. We have provided a quantitative multi-parametric characterization which sets baseline measurements that may be useful for sequence optimization to further enhance visualisation, and provide reference values for future studies investigating pathological differences in habenula microstructure.
Impact of (Recurrent) Bacterial Vaginosis on Quality of Life and the Need for Accessible Alternative Treatments
Authors: Chow Karen , Wooten Darcy , Annepally Sindhuja , Burke Leah , Edi Rina , Morris Sheldon R. 
Published: October 2022

Abstract
Background: Bacterial vaginosis (BV) is one of the most common vaginal conditions in women aged 15-44 years old.
Methods: We administered a cross-sectional, single timepoint survey to women ages 18 years or older and who have had bacterial vaginosis (BV). Women completed an anonymous online survey evaluating the impact of BV on their quality of life, how effective different types of treatments were and the amount of self-diagnosed vs. provider diagnosed BV episodes they had.
Results: 62 participants completed the anonymous online survey. With a self-reported median number of BV episodes in the past year was 4 (IQR 1-7). Among these women 69.8% reported BV had a negative impact on their sexual health, 67.7% on their physical health, 74.6% on their mental health. More than half of the respondents had used probiotics with oral lactobacillus sp. (53.2%), mainly by oral route, and over a third had used vaginal boric acid (37.1%). Most women were unaware of lactobacillus crispatus. Lactobacillus probiotics were more likely to be tried by women who were negatively impacted by BV for overall quality of life (p=0.033), sexual health (p=0.002), and mental health (p=0.006) while boric acid use was more likely to be used by women who were negatively impacted by BV for their sexual health (p=0.008).
Conclusions: BV is associated with negative quality of life and the women most impacted are seeking alternative treatments such as probiotics (lactobacillus) and boric acid. There needs to be improvements in BV treatment that include alternative therapy options that have demonstrated efficacy with standardized composition, formulation and dosage.
Information needs, sources and access by small-scale horticultural crop farmers in Tanzania: a case of Morogoro urban district
Authors: Masele Juma James 
Published: October 2022

Abstract
This study investigates Morogoro Urban horticultural farmers’ information needs, sources and access, using 112 respondents interrogated through questionnaires, observation and interviews. Farmers needed information on sowing/harvesting time, disease and pest control, erosion control, harvests storage, produces markets. Friends/colleagues ranked as important information source, followed by Extension Officers, libraries, Internet, friends/peers, cooperatives, Nanenane festival, radio and newspapers. Challenges include unavailability of extension officers, long distance to/from libraries. Recommends equipping small-scale horticultural crop farmers will add value to information exchanged through interpersonal relationship. Employing more skilled extension officers, and use of modern ICT to improve horticultural farmers’ information access is also emphasized.
Mortality from all causes before and during the COVID-19 pandemic in Peru: The role of sociodemographic factors and accessibility
Authors: Quispe Antonio M. , Vargas Lucía , Morales-García Wilter C. , López-Gonzales Javier L. , Sánchez-Garcés Jorge 
Published: October 2022

Abstract
Peru suffered the highest mortality rates worldwide during the COVID-19 pandemic. In this study, we assessed the Peruvian districts' all causes of mortality-associated sociodemographic factors before and during the COVID-19 pandemic using mixed-effects Poisson regression models. During the pre-pandemic and the first four COVID-19 waves, the Peruvian districts reported mean weekly mortality of 22.3 (standard deviation 40.4), 29.2 (38.7), 32.5 (47.2), 26.8 (38.9), and 24.4 (38.0), respectively. We observed that before the COVID-19 pandemic, the districts' weekly deaths were associated with the human development index ((HDI) adjusted incidence rate ratio (aIRR) 0.11 (95% confidence interval 0.11–0.12)), accessibility (aIRR 0.99 (0.99–0.99)), poverty (aIRR 0.99 (0.99–0.99)), and anemia (aIRR 0.99 (0.99–0.99)). However, during each of the first four COVID-19 waves, the magnitude of association between the districts' weekly deaths and HDI decreased (first, aIRR 0.61 (0.58−0.64); second, aIRR 0.54 (0.52−0.57); third, aIRR 0.20 (0.19−0.22); fourth, aIRR 0.17 (0.15−0.19)), but the association with accessibility (aIRR 0.99 (0.99–0.99)), poverty (aIRR 0.99 (0.99–0.99)), and anemia (aIRR 0.99(0.99–0.99)) remain constant. Before and during the COVID-19 pandemic, a solid association existed between all-cause mortality and the district's sociodemographics, increasing with lower HDI, accessibility, poverty, and anemia rates.
Continuous increase in evaporative demand shortens the growing season of European ecosystems in the last decade
Authors: Rahmati Mehdi , Graf Alexander , Terán Christian Poppe , Amelung Wulf , Dorigo Wouter , Hendricks-Franssen Harrie-Jan , Montzka Carsten , Or Dani , Sprenger Matthias , Vanderborght Jan , Verhoest Niko , Vereecken Harry 
Published: October 2022

Abstract

Although it has been shown that climate warming has steadily increased the length of the growing season (LGS) in Europe, we present new evidence that this trend reversed during last decade. Warmer European winter and spring weather combined with adequate soil moisture still results in early greening, albeit at slower rates than in the past. However, the recent (2014-2020) accelerated shift toward earlier onset of dormancy has resulted in a shortening of LGS compared to previous years. The results show that this is mainly due to higher atmospheric water demand (AWD) in summer. The higher AWD stresses the vegetation even though there is still enough water, but the vegetation cannot provide the needed water for transpiration because the water transport system is inadequate, or the root system is adapted to conditions other than the current condition. Our results have implications for future management of European ecosystems in a warmer world.