bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference Uptake of 99mTc-Pyrophosphate vs 99mTc- Methylenediphosphate in Detecting Cardiac Amyloidosis; First Experience in Hasan Sadikin General Hospital
Authors: Marzuki Hadi , Soeriadi Erwin A , Astuti Astri , Budiawan Hendra , Kartamihardja Achmad Hussein S 
Published: May 2022

Cardiac amyloidosis (CA) is a disorder caused by deposits of insoluble fibrils in the myocardium and an underdiagnosed cause of heart failure. Immunoglobulin Light Chain-Associated Amyloid (AL) and Amyloidosis Transthyretin-related (ATTR) are the two protein precursors that most commonly cause cardiac amyloidosis. It is important to distinguish between these two types of amyloidosis because the treatment and prognosis of each types is different. Recent advances in cardiac radionuclide imaging, in particular using bone-seeking agents such as 99mTc-Pyrophosphate (PYP) and 99mTc-Methylenediphosphate (MDP), can differentiate AL from ATTR. This study aimed was to investigate the uptake characteristic of both tracers in CA. Three patients with suspected of having cardiac amyloidosis underwent two cardiac radionuclide imaging examinations using those two different radiopharmaceuticals. The cardiac images were analyzed quantitatively and semi-quantitatively based on ASNC (American Society of Nuclear Medicine) criteria. Cardiac radioactivity uptake of 99mTc-PYP was better from those of 99mTc-MDP based on quantitative as well as semi-quantitative (visual assessment).
Keywords: cardiac amyloidosis; cardiac imaging; 99mTc-PYP; 99mTc-MDP
Skilling People in Nepal: Reality Vs Dream
Authors: Lamsal Hari Prasad , Bajracharya Anil Muni 
Published: May 2022

Skilling people is channeled through formal, informal or non-formal education systems in Nepal. Formal education includes structured curriculum and mode of delivery where knowledge and skills are acquired in a hierarchical layer. Non-formal education includes the skill development activities in a less structured patterns, whereas imparting knowledge and skills from generation to generation falls under the category of informal mode of education. Similarly, skills development in formal system includes four different types of programs in Nepal. These are short-term training program, professional development program, secondary level technical and vocational education program (including diploma level program) and technical higher education program. This paper opens discussion on these programs, uncovers issues and challenges and suggests some measures for the improvement of program design and implementation.
While preparing the paper, secondary documents are analyzed. In some cases, author's experiences are also used. This article is expected to contribute knowledge to the skill development efforts in Nepal.
ЗАКОНОДАВЧЕ ЗАБЕЗПЕЧЕННЯ САМОСТІЙНОЇ РОБОТИ СТУДЕНТІВ У НАЧАЛЬНОМУ ПРОЦЕСІ ВИЩИХ ЗАКЛАДІВ ОСВІТИ II ПОЛОВИНИ XIX ПОЧАТКУ XX СТ.
Authors: Бенера В.Є. 
Published: May 2022

Здійснено історико-педагогічний аналіз нормативно-законодавчої бази та довідково-статистичних видань проблеми самостійної роботи студентів у навчальному процесі ВНЗ України (друга половина ХІХ – початок ХХ ст.). На конкретних прикладах розкрито процес зародження нормативно-правових механізмів освітньої діяльності у питаннях вищої освіти. Зазначено, що реформаторські процеси і перетворення в освітній сфері носять особливий регіональний характер на Лівобережній та Правобережній Україні. Зроблено висновок, що нормативно-законодавчі, статистично-довідкові видання відображають своєрідність теорії та практики самостійної роботи студентів у навчальному процесі ВНЗ досліджуваного періоду.
ПСИХОЛОГО-ПЕДАГОГІЧНИЙ АНАЛІЗ СТАНОВЛЕННЯ КАТЕГОРІЇ "САМОАНАЛІЗУ"
Authors: Малихін О.В. 
Published: May 2022

Висвітлено основні аспекти психолого-педагогічного аналізу категорії «самоаналізу», підходи до визначення понять. З’ясовано, що у ході розвитку педагогічної думки проблему самоаналізу вивчали з двох позицій: необхідність звернення до самоаналізу учня задля самоосвіти і необхідність самоаналізу педагогу, з метою професійного самопізнання і самовдосконалення. Встановлено, що в контексті проектування спеціальних педагогічних умов для становлення діяльності самоаналізу в майбутнього вчителя надзвичайно важливим виявляється визначення у якості результату діяльності самоаналізу не лише накопичення студентом уявлень про себе, але й накопичення досвіду самоаналітичної діяльності, його збагачення.
ШЛЯХИ МОДЕЛЮВАННЯ ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ МАЙБУТНЬОГО ВЧИТЕЛЯ МУЗИКИ МУЛЬТИМЕДІЙНИМИ ЗАСОБАМИ НАВЧАННЯ
Authors: Бондаренко А.В. 
Published: May 2022

Розкрито механізми моделювання професійної діяльності майбутнього вчителя музики на основі закономірностей поліфункціональної культури. З’ясовано функції заміщення та особливості задачного підходу в процесі моделювання професійної діяльності. Визначено сутність понять «синестетика» і «синестезія». Висвітлено шляхи використання метафор. Розкрито можливості синтезу різних видів мистецтв. Проаналізовано особливості поєднання наукових та художніх засобів пізнання світу.
ПРИНЦИПИ ТА СПОСОБИ ОПТИМІЗАЦІЇ НАВЧАЛЬНО-ВИХОВНОГО ПРОЦЕСУ НА УРОКАХ З ТРУДОВОГО НАВЧАННЯ В ЗАГАЛЬНООСВІТНІЙ ШКОЛІ
Authors: Мрук М.М. 
Published: May 2022

Розглянуто основні принципи та способи оптимізації викладання трудового навчання в загальноосвітній школі на основі методичних міркувань і дослідження їх сутності. Запропоновано конкретні шляхи оптимізації навчального процесу з метою оволодіння вчителем певними методами викладання, що дозволять досягнути найкращих результатів навчально-пізнавальної діяльності. Зроблено висновок, що оптимальна організація навчального процесу потребує від учителя творчого підходу. Оптимізація навчання припускає, що вчитель при підготовці до кожного заняття буде спиратися на закономірності та принципи навчання і творчо обирати найкращий варіант вивчення нового навчального матеріалу.
ВИКОРИСТАННЯ ДІЛОВИХ ІГОР НА УРОКАХ ГЕОГРАФІЇ ЯК ЗАСІБ ПІДВИЩЕННЯ ПІЗНАВАЛЬНОГО ШТЕРЕСУ УЧШВ
Authors: Повтораченко Н.О. 
Published: May 2022

Висвітлено різні підходи до поняття «ділова гра». Представлено результати педагогічного експерименту з використання ділових ігор на уроках географії як засобу розвитку пізнавального інтересу учнів. За результатами спостережень виявлено, що знання засвоюються набагато краще, якщо вони спонукають учнів зацікавитися, пізнати їх сутність. Обґрунтовано, що ділова гра як метод навчання має всі якості, щоб активно формувати пізнавальний інтерес. Окреслено умови, за яких пізнавальний інтерес буде формуватися засобом ділових ігор.
PEDAGOGICAL INTERACTION OF TEACHER AND STUDENTS AS MEANS OF CREATIVE PERSONALITY FORMATION LEARNING PROCESSES
Authors: Dolzhkova S.O. 
Published: May 2022

Pedagogical relationship between the teacher and pupils is a method of forming a creative personality in the process of studying.
This article is talked about the peculiarities of forming the creative personality in the conditions of realizing the pedagogical relationship between the teacher and pupils. They analyze the influence of psychological development and demands of teenagers on the organized basis of creative relationships. The author stresses the contrasts between the theory of pedagogical relationship and real school life. The author tells about the necessary conditions for realizing the personality of a child and his self-determination in the process of studying.
Use of Face Masks and Self-Perceived Breath Odour Amidst Covid-19 Pandemic- A Cross Sectional Online Questionnaire-Based Study
Authors: Zubair Ahmad Janbaz  , Basharat Ahmad Mir  , Suhail Majid Jan  , Roobal Behal  
Published: May 2022

Background: Self-perception rate of bad breath is usually low. Unprecedented and massive use of face masks throughout the Covid-19 pandemic could have a bearing on increased self-perception of breath odour.
Aims and Objectives: To assess self-perceived breath odour (SPBO) associated with unprecedented wearing of face masks amidst Covid-19 pandemic.
Methodology: A cross-sectional study was carried out involving 547 subjects. A well-structured breath odour questionnaire was sent to the participants utilizing online social media platforms. The data collected was assessed and statistically analysed.
Results: Changes in self-perceived breath odour were reported by 190 participants. Females had higher SPBO than males post Facemask usage. Post pandemic SPBO were significantly associated with smoking, systemic conditions, and the period of face mask use and previous diagnosis of halitosis.
Conclusion: Wearing of facemasks are pronouncedly associated with self-perceived breath odour which is highly associated with the time period of its use. SPBO after facemask usage is significantly more in smokers, those on medication and those having previously been diagnosed with halitosis.
Keywords: breath odour, COVID-19, face mask, halitosis, self-perception
MODIFIKASI METODE RUNGE-KUTTA-KUNTZMANN BERDASARKAN RATA-RATA PANGKAT P = 1/2
Authors: Riski Andika , Wartono Wartono 
Published: May 2022

Metode Kuntzmann merupakan salah satu bentuk khusus dari metode Runge-Kutta orde empat yang di gunakan untuk menyelesaikan persoalan nilai awal. Penelitian ini membahas modifikasi metode Kuntzmann berdasarkan rata-rata pangkat untuk memperoleh varian baru metode Kuntzmann. Berdasarkan hasil kajian menunjukkan bahwa modifikasi metode Kuntzmann menggunakan rata-rata pangkat (MKunP) mempunyai galat pemotongan lokal sebesar . Simulasi numerik diberikan untuk menguji akurasi MKunP dengan menggunakan dua contoh persoalan nilai awal. Pada simulasi ini, galat mutlak MKunP dibandingan dengan metode Kuntzmann dan modifikasi metode Kuntzmann berdasarkan rata-rata harmonik (MKunH). Hasil simulasi numerik menunjukkan bahwa metode MKunP lebih baik dibandingkan dengan MkunH.
Botulinum therapy in treatment of patients with rosacea
Authors: Verbovaya E. D. , Rodina A. L. 
Published: May 2022

The article deals epidemiology, pathomorphological picture, trigger factors of development, peculiarities of treatment with the use of botulinum therapy for rosacea. A clinical case is presented.Purpose of the article. Consider the pathogenesis of rosacea, investigate the molecular mechanism by which botulinum toxin improves the condition in rosacea.Material and methods. The article presents clinical examples of botulinum therapy in the treatment of patients with rosacea. The epidemiology, pathomorphological picture, developmental trigger factors, diagnostic features and approaches to the treatment of rosacea in modern conditions are considered.Results. Case study results show that intradermal botulinum toxin injections are safe and effective in reducing erythema and ﬂushing in rosacea.Conclusions. Botulinum therapy – may be an alternative therapy for patients with refractory to standard treatment of persistent erythema. The effect after botulinum therapy lasts for 2–4 months. Further research is needed on the effcacy and safety of this technique in patients with different subtypes of rosacea, including those with a combination of subtypes.
Selective inhibition of JAK1 in treatment of atopic dermatitis: Prescription features and experience with upadacitinib
Authors: Kruglova L. S. , Michenko A. V. , Lvov A. N. , Hotko A. A. 
Published: May 2022

Therapy of moderate-to-severe atopic dermatitis (AD) is associated with a number of diffculties due to the propensity of the disease to a chronic relapsing course, the tendency to develop in childhood and young age. However, a new selective JAK1 inhibitor, which suppresses cytokineinduced inﬂammation in the skin, has been added to the arsenal of AD systemic therapy.Objective. To evaluate the effcacy, antipruritic activity, impact on quality of life, levels of anxiety and depression, and safety of upadacitinib treatment of moderate-to-severe AD in adult patients.Material and methods. The inclusion criteria were the presence of moderate-to-severe AD, age over 18 years, signed informed consent of the patient to participate in the study. Effcacy was assessed based on clinical indices. All patients received upadacitinib (RANVEK) 15 mg once daily with or without food, topical corticosteroids (if needed), and emollients.Results. The number of patients with an IGA score of 0 or 1 was 50%. The dynamics of the maximum intensity of pruritus according to NRS during 16 weeks of therapy was 56.4%. The proportion of patients with an improvement in the assessment of the maximum severity of itching according to NRS ≥3 points at week 16 relative to the baseline was 77.8%. The dynamics of the EASI index in percent was 65.3%, and the number of patients who achieved an EASI-50 response at week 16 was 83.3%, EASI-75 was 61.1%. The dynamics of the overall SCORAD index as a percentage of the initial value for 16 weeks was 76.9%. The DLQI decreased by 68.9%. The number of patients with HADS less than 7 points on a scale of both anxiety and depression was 88.9%.Conclusions. Thus, upadacitinib demonstrates high effcacy in terms of the effect on rashes and pruritus, favorably affects the quality of life and psychosomatic characteristics of patients, and has a favorable safety profle in the treatment of moderate and severe AD in adults.
Choice of frst drug of genetically engineered therapy: Benefts of guselcumab
Authors: Kruglova L. S. , Shatokhina E. A. , Polonskaya A. S. , Syryseva A. Yu. 
Published: May 2022

When choosing the frst drug for genetically engineered biological therapy (GEBT), the following are taken into account: the psoriasis phenotype, diagnosed PsA or predictors of its development, the presence of comorbid pathology, contraindications, dosing regimen, the rate of onset of the effect, and the ‘survival rate’. With the advent of new classes of GEBT-drugs, the concept of ‘treat to target’ has been formed, in accordance with which the importance of achieving clear or almost clear skin as a goal of psoriasis therapy has been noted, since studies have shown that achieving clear or almost clear skin (PASI 90, 100) correlates with higher indicators of health-related quality of life. The concept is reduced to the long-term prescription of highly effective and safe therapies (methods) with a high level of evidence in medicine (A, B). The evolution of GIBT has led to the emergence of a new class of anti-IL-23 drugs. The article presents data from clinical studies on the effcacy and safety of the use of the interleukin-23 blocker guselcumab. Own clinical cases are presented with a discussion of the choice made in favor of guselcumab as the frst genetically engineered drug.Conclusions. Data from clinical trials on the high effcacy, ‘survival rate’ and safety of guselcumab in patients with psoriasis and psoriatic arthritis allows, including those with comorbid pathology, to consider it as a starting therapy using genetically engineered drugs. The data of our own results of observation allow us to conclude that guselkumab is highly effective in psoriasis of smooth skin, as well as in lesions of the scalp, anogenital area, with involvement of the nail plates in the process, which justifes its appointment as the frst GIBT drug.
Effectiveness of laser therapy in correction of cytokine status and skin barrier function in children with atopic dermatitis
Authors: Dontsova E. V. , Ivanova I. I. , Novikova L. A. , Dontsov V. G. , Borzunova L. N. , Koroleva T. V. 
Published: May 2022

Aim. To evaluate the effectiveness of low-intensity laser blood irradiation for the correction of the cytokine profle and violations of the skin barrier function in the complex treatment of children with atopic dermatitis.Material and methods. The study included 65 children with atopic dermatitis (AtD) (mean age 8 ± 2,9 years) and 30 healthy children (control group). The patients were divided into two groups depending on the treatment: group 1 – basic drug therapy (BDT), group 2 – BDT in combination with supravenous laser blood irradiation (NLBI). Blood cytokine status indicators were assessed – levels of interleukins (IL) -4,-10,-13,-18, tumor necrosis factor-alpha (TNF-α), indicators of skin barrier function (skin pH, skin moisture, transepidermal water loss – TEWL) before treatment, after 1 and 3 months from the start of treatment.Results. Basic drug therapy had the least effect on the cytokine profle of the blood of patients and parameters characterizing the barrier function of the skin. The inclusion of NLBI was accompanied by an anti-inﬂammatory effect, signifcantly enhanced the regulatory effect on blood cytokine activity, signifcantly improved the barrier function parameters studied (skin pH, skin moisture, TEWL) and reduced the frequency of disease relapses.Conclusions. Basic drug therapy did not have a statistically signifcant corrective effect on the parameters of the immune status and skin barrier function in children with AtD. The combined use of NLBI and BDT increases the effciency of correction of the blood cytokine profle and violations of the skin barrier function in children with AtD, leads to a decrease in the frequency of disease relapses, which indicates the advantage of this method compared to monotherapy with basic drugs.
AgNPs Aggravated Hepatic Steatosis, Inflammation, Oxidative Stress, and Epigenetic Changes in Mice With NAFLD Induced by HFD
Authors: Wen Ling , Li Minyan , Lin Xiaojun , Li Yan , Song Huidong , Chen Hanqing 
Published: May 2022

The recent development of silver nanoparticles (AgNPs) has sparked increased interest in biomedical and pharmaceutical applications, leading to the possibility of human exposure. The liver is the primary target organ in the metabolism and transport of nanoparticles. Non-alcoholic fatty liver disease (NAFLD) is the most common and leading cause of hepatic metabolic syndrome with approximately 15% of patients will develop into non-alcoholic steatohepatitis, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Thus, the potential hepatotoxicity of AgNPs on NAFLD development and progression should be of great concern. Herein, we explored the potential hepatic effect of a single intravenously injected dose of 0.5, 2.5, and 12.5 mg/kg BW on the liver function of high-fat-diet (HFD)-fed mice for 7 days. AgNP treatment increased serum levels of alanine aminotransferase, aspartate transaminase, triglycerides and cholesterols, the number of lipid droplets, and the contents of triglycerides and cholesterols in NAFLD mice livers compared to HFD-fed mice. The mechanism of AgNP-induced worsen hepatotoxicity in mice is associated with hyperactivation of SREBP-1c-mediated de novo lipogenesis and liver inflammation. Additionally, HFD-fed mice treated with AgNPs had significantly higher oxidative damage and lower global DNA methylation and DNA hydroxymethylation than NAFLD mice. This study suggests that AgNP treatment exacerbated HFD-induced hepatic steatosis, liver inflammation, oxidative stress, and epigenetic changes in mice, which is relevant to the risk of AgNP exposure on NAFLD development and progression.
Impact Of Prepregnancy Overweight And Obesity On Treatment Modality And Pregnancy Outcome In Women With Gestational Diabetes Mellitus
Authors: Linder Tina , Eder Anna , Monod Cécile , Rosicky Ingo , Eppel Daniel , Redling Katharina , Geissler Franziska , Huhn Evelyn A. , Hösli Irene , Göbl Christian S. 
Published: May 2022

BackgroundWe aim to evaluate the impact of prepregnancy overweight on treatment modalities of Gestational Diabetes Mellitus (GDM). We assessed the association of increased pregravid Body Mass Index (BMI) with dosing of basal and rapid acting insulin as well as pregnancy outcome.MethodsWe included 509 gestational diabetic women (normal weight: 200, overweight: 157, obese: 152), attending the pregnancy outpatient clinic at the Department of Obstetrics and Gynecology, Medical University of Vienna, in this retrospective study. We used a prospectively compiled database to assess patient characteristics, treatment approaches – particularly maximum doses of basal and rapid acting insulin or metformin – and pregnancy outcome.ResultsIncreased BMI was associated with the need of glucose lowering medication (odds ratio (OR): 1.08 for the increase of 1 kg/m² BMI, 95%CI 1.05–1.11, p&lt;0.001). Mothers with pregestational obesity received the highest amount of insulin. Metformin was more often used in patients with obesity who also required higher daily doses. Maternal BMI was associated with increased risk of cesarean section (OR 1.04, 95%CI 1.01–1.07, p&lt;0.001) and delivering large for gestational age offspring (OR 1.09, 95%CI 1.04–1.13, p&lt;0.001). Birthweight percentiles were highest in patients with obesity who required glucose lowering therapy.ConclusionsTreatment modalities and outcome in GDM pregnancies are closely related to the extent of maternal BMI. Patients with obesity required glucose lowering medication more often and were at higher risk of adverse pregnancy outcomes. It is crucial to further explore the underlying pathophysiologic mechanisms to optimize clinical management and individual treatment approaches.
High Prevalence of Cardiometabolic Comorbidities Among Children and Adolescents With Severe Obesity From a Large Metropolitan Centre (Hangzhou, China)
Authors: Wang Jinling , Lin Hu , Chiavaroli Valentina , Jin Binghan , Yuan Jinna , Huang Ke , Wu Wei , Dong Guanping , Derraik José G. B. , Fu Junfen 
Published: May 2022

ObjectiveThis study aimed to describe the clinical characteristics of children and adolescents with obesity, and the prevalence of cardiometabolic comorbidities over 10 years in this population from a large metropolitan centre in China.MethodsThis was a cross-sectional study (2008–2017) of patients aged &lt;18 years with obesity [body mass index (BMI) ≥ 95th percentile for age and sex] enrolled at the Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine (Hangzhou, Zhejiang Province). Clinical assessments included anthropometry, blood pressure, liver ultrasound, lipid profile, oral glucose tolerance test, and uric acid. For examination of outcomes, our study cohort was stratified by sex and age bands (&lt;10 vs. ≥10 years), with the study period also split into two strata (2008–2012 and 2013–2017).ResultsA total of 2,916 patients (1,954 boys and 962 girls) were assessed at a mean age of 10.5 years. Patients almost invariably presented severe obesity (median BMI SDS = 2.98; Q1 = 2.60, Q3 = 3.39). Obesity-related comorbidities were common among boys and girls, including type 2 diabetes mellitus (2.6% and 3.6%, respectively), abnormal glycaemia (33.6% and 35.5%, respectively), hypertension (33.9% and 32.0%, respectively), dyslipidaemia (35.2% and 39.6%, respectively), hyperuricaemia (16.2% and 8.3%, respectively), acanthosis nigricans (71.9% and 64.0%, respectively), abnormal liver function (66.9% and 47.0%, respectively), and non-alcoholic fatty liver disease (NAFLD) (63.8% and 45.1%, respectively); 38.7% of boys and 44.4% of girls aged ≥10 years had metabolic syndrome. Notably, the incidence of many cardiometabolic comorbidities was in 2013–2017 compared to 2008–2012. For example, rates of hypertension among boys aged &lt;10 years and aged ≥10 years rose from 28.4% and 26.5% to 48.0% and 35.8%, respectively, and in girls from 20.3% and 20.8% to 41.7% and 39.6%, respectively. In 2013–2017, 9.5% of girls in the older group had metabolic syndrome compared to 2.2% in 2008–2013.ConclusionsWe observed a high incidence of obesity-related cardiometabolic comorbidities among Chinese children and adolescents with severe obesity over 10 years. It was particularly concerning that rates of several comorbidities rose markedly over the study period, highlighting the need to address the obesity epidemic early in life (in China and elsewhere) to prevent the development of obesity-related comorbidities and, subsequently, of overt disease.