bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grain Production Space Reconstruction and Its Influencing Factors in the Loess Plateau
Authors: Qin zhangxuan , Liu Xiaolin , Lu Xiaoyan , Li Mengfei , Li Fei 
Published: April 2022

Abstract

Land systems can be classified spatially as grain production space, ecological service space and urban-rural development space. Grain production space reconstruction concentrates the principal contradictions in land system changes. Exploring the process, pathways and influencing factors of grain production space reconstruction can coordinate the trade-off/synergy among grain production, ecological protection and economic development. Therefore, the reconstruction characteristics of grain production space in the Loess Plateau were systematically analyzed in terms of quantity, quality, and spatial pattern in this study. Results showed that although the quantity of grain production space in the Loess Plateau declined, the quality improved between 1980 and 2018. The grain production space in the Loess Plateau was increasingly fragmented and scattered, with more regular shapes in 2018 than 1980. Moreover, the center of gravity of grain production space moved 8.32 kilometers to the northwest; it moved more significantly to the northwest when considering the quality of grain production space. The reconstruction of grain production space in quantity, quality and spatial pattern was mainly realized through the pathways of Grain for Green, Urban Expansion, Deforestation and Reclamation as well as Land Consolidation; and the pathways of Grain for Green after 2000 was the principal pathway for grain production space reconstruction. The four reconstruction pathways of grain production space in the Loess Plateau were the result of a combination of natural environment and socio-economic factors, but driving factors had different strengths and directions for each reconstruction pathway. This study offered a comprehensive understanding of grain production space reconstruction, and provided a new research perspective for coordinating grain production, ecological protection and high-quality economic development.
Visualizing Subsoil Structure for Evaluating the Efficiency of Mole Drain in Heavy Clay Soils Using Geo-electrical Methods
Authors: Aziz Akram , Attia Tamer , Hamed Yasser , Selim Tarek 
Published: April 2022

Abstract
Geo-electrical surveys have been conducted on three newly reclaimed farms located on the northeastern corner of the Nile Delta, Egypt. These farms always suffer from various soil salinization problems. The surveys include measuring the natural Spontaneous Potential (SP) of the soil, apparent Resistivity Gradient (RG), and Electrical Resistivity Tomography (ERT). The study aims to image the soil structure and evaluate the effectiveness of the traditional Mole Drainage (MD) systems that are customarily utilized to reduce soil salinity of the farms in this region. Integrating the results of the surveys conducted on the first farm shows that the subsurface heavy clay-bed is very close to the topsoil. This proximity reduces the role of the MD in draining the soil. On the second farm, the clay-bed did not reach the soil surface of the farm, and a significant reduction in soil salinity levels nearby the Mole drains was observed. However, the limited thickness of the root zone was not sufficient to plant deep-rooted vegetation. Repeating the ERT measurements on the third (barren) farm revealed a severe defect in the farm drainage network, where the slope of the clay-bed opposes the main direction of the surface drainage system of the farm. This has resulted in groundwater accumulation and a frequent occurrence of waterlogging.Eventually, the efficiency of any drainage network does not depend solely on its surface maintenance. It is important to figure out the subsurface conditions of the soil as well. The methods have proven to be effective and applicable tools in imaging soil subsurface conditions nondestructively, even in lands characterized by high clay content.
FaceMemNet: Predicting Face Memorability with Deep Neural Networks
Authors: Mohsenzadeh Yalda , Younesi Mohammad 
Published: April 2022

Abstract
With the advent of social media in our day to day life, we are exposed to plenty of images, especially face photographs, every day. Recent behavioural studies have shown that some of these photographs stick in the mind better than others. However, it is still unclear what factors make a picture more or less memorable. Previous research have shown that memorability is an intrinsic property of an image, hence the memorability of an image can be computed from that image. Moreover, various works found that the memorability of an image is highly consistent across people and also over time. Recently, researchers employed deep neural networks to predict image memorability. Here, we show although those models perform well on scene and object images, they perform poorly on photographs of human faces. We demonstrate and explain why generic memorability models do not result in an acceptable performance on face photographs and propose seven different models to estimate the memorability of face images. In addition, we show that these models outperform the previous classical methods, which were used for predicting face memorability.
Predicting Drug-Efficiency and Cancer Evolution Using an Automated Histological Classifification Based on Whole Slide Images
Authors: Pan Yating , Liao Xinyi , Ruan Xiang , Deng Yating , Du Fan , Yu Guanzhen , Wu Xiaojun 
Published: April 2022

Abstract
Liver disease is a general term for all diseases that occur in the liver, including cirrhosis, tumors, and drug-induced injury. Liver pathology reveals the pathological appearance of various common liver diseases. Automated classification of liver pathological features based on whole slide images can help observe disease processes and assess drug efficacy, and reduce scientific fraud. Using pathological slides of rat liver induced by the chemical carcinogen TAA, we developed a deep-learning framework to detect abnormal lesions in rat liver from whole histopathological slides. Our framework provides an objective and reproducible method to observe liver lesions and also calculates the proportion of lesions in each liver slide. The framework can also clearly delineate the edges of the liver, revealing whether there are uneven, jagged or wavy surfaces. This tool not only discloses the multi-level pathological evolution of cholangiocarcinoma, but also presents a visual image of the protective effect administered by H2. Artificial intelligence-based algorithms are highly promising methods for studying cancer evolution, assessing drug efficiency, and reducing scientific misconduct.
NLRX1 Ligand, Docosahexaenoic Acid, Ameliorates LPS-Induced Inflammatory Hyperalgesia by Decreasing TRAF6/IKK/IkB-a/NF-kB Signaling Pathway Activity
Authors: Yilmaz Dilsah Ezgi , Senol Sefika Pinar , Temiz-Resitoglu Meryem , Sahan-Firat Seyhan , Tunctan Bahar 
Published: April 2022

Abstract
Objective The nucleotide-binding oligomerization domain-like receptor X1 (NLRX1) has been associated with various anti-inflammatory mechanisms. We investigated whether the NLRX1 ligand docosahexaenoic acid (DHA) ameliorates lipopolysaccharide (LPS)-induced inflammatory hyperalgesia by interacting with tumor necrosis factor receptor-associated factor 6 (TRAF6)/inhibitor of kB (IkB) kinase (IKK)/IkB-a/nuclear factor-κB (NF-κB) signaling pathway in the central nervous system. Methods Reaction time to thermal stimuli within 30 seconds was measured in male mice injected with saline, lipopolysaccharide (LPS), and/or DHA after 6 hours using the hot plate test. Co-immunoprecipitation and immunoblotting studies were performed to determine activation of the TRAF6/IKK/IkB-a/NF-kB pathway in the brains and spinal cords of LPS-treated animals. Results Latency to the thermal stimulus was reduced by 30% in LPS-injected endotoxemic mice compared with saline-injected mice. Treatment with DHA significantly improved latency compared with endotoxemic mice. In the brain and spinal cord of LPS-injected mice, treatment with DHA also prevented the increase in the expression and/or activity of (1) IKK/IKKβ, IKK, and K63 U in the NLRX1-immunoprecipitated tissues, (2) IKK/IKKβ, K63 U, and K48 U in the IKK-immunoprecipitated tissues, and (3) IkB-α, NF-kB p65, and interleukin-1β associated with decreased IkB-α expression. Conclusion Inhibition of IKK/IkB-a/NF-kB signaling by dissociation of NLRX1 from TRAF6 in response to LPS treatment may contribute to the protective effect of DHA against inflammatory hyperalgesia.
The COVID-19 pandemic’s impact on health service utilization among pregnant women in three Nigerian States: a mixed methods study
Authors: Orji Bright , Bryce Emily , Odio Bartholomew , Onuoha Herbert , Njoku Elizabeth , Anoke Charity , Ugwa Emmanuel , Enne Joseph , Oniyire Adetiloye , Ibrahim Idris , Otolorin Emmanuel , Afolabi Kayode , Ogbulafor Nnenna C. , Oliveras Elizabeth , Nwani Chinyere 
Published: April 2022

Abstract
BackgroundCOVID-19 disrupted health service delivery and weakened global and national health systems. The objective of this study was to describe the changes in health service utilization in three local government areas in three Nigerian states and examine factors involved.MethodsA cross-sectional mixed-methods approach was used to examine changes in service utilization during the first nine months of the COVID-19 pandemic and associated factors in three Nigerian states; Ebonyi, Niger and Ondo. A total of 315 pregnant women seen for antenatal care in 80 health facilities between October 1 and November 30, 2020, participated in exit interviews; 93 women participated in focus group discussions (FGDs). Descriptive analyses and a multivariable logistic analysis were conducted to examine associations between characteristics and decreased service utilization. Content analysis was used to identify the emerging themes for factors that impacted health service utilization during the pandemic.ResultsOne quarter of women surveyed reported that they reduced or ceased health service utilization during this initial period of the pandemic. The biggest reported changes in visits were for immunization (47% pre-pandemic versus 30% during the pandemic, p<0.001) and a small but statistically significant decline in antenatal care (99% to 94%, p<0.001) was observed.State of residence was significantly associated with reduced or ceased utilization during the pandemic (p<0.01); other sociodemographic characteristics were not. Qualitative findings show that lockdowns, transportation issues, increased costs and fear of contracting COVID-19 or being labeled as COVID-positive were the most common reasons mentioned for not seeking care during this period of the pandemic. Conclusions The pandemic from March to November 2020 negatively impacted health service utilization amongst pregnant women in Nigeria. A better understanding of differences in the pandemic and state response could help inform future actions. The FGDs findings highlight the need for health systems to consider how to facilitate service utilization during a pandemic, such as providing safe transport or increasing outreach, and to minimize stigma for those seeking care.
Anthropocene Cyclogenesis over Bay of Bengal, Prediction by SMOreg, and Odisha Coast Landfall
Authors: Mishra Siba Prasad , ojha ananta charan , Sahu Deepak kumar 
Published: April 2022

Abstract
Background
Recurrent tropical cyclones of thermal origin in the Bay of Bengal have regular damage to the 480km Odisha coasts of the east coast of India. The causes are violent wind, torrential rain, and storm surge inundations. The high sea surface temperature (> 270C), relative humidity, wind shear, Coriolis force, preexisting disturbances, warm oceanic current, easterly trade wind, and upper air cyclonic circulation. Odisha receives a lion’s share of the cyclogenesis of the Bay of Bengal and is shattering the coastal inhabitants and the ecosystem.
Methodology and Results:
The cyclone data of India Meteorological Department from 1891 to 2020, post-Holocene, pre-Anthropocene, and golden spike periods are analyzed statistically. The categorization, naming, cause of ample cyclogenesis in the Bay of Bengal particularly along Odisha coast are discussed in the present study. The geological stratification, meteorological players, and coastal features of Odisha coast are discussed. The trend in CD’s, CS, and SCS has been studied and prediction of these storms that shall brew and grow over Bay of Bengal fabric from 1980 to 2021, (during the golden spike period of the Anthropocene period) by using Linear regression and SMOreg soft computing machine learning model has been forecasted.
Conclusions
The decrease in cyclogenesis frequency but increase in amplitude, intensity, and severity is the present trend along with a southerly shift of landfall along the east coast. The reason is that the southwest monsoon brings with it high wind shear, which hinders cyclone development, and variation in wind layer shear.
Chinese dentists' use of teledentistry and its influencing factors - A Cross-sectional study
Authors: Yang Zheng , wu kan , li weiming , tang tian , Yin Wei 
Published: April 2022

Abstract
Background We investigated the factors influencing the utilization of teledentistry among dentists to improve the effective use of teledentistry in clinical work. Further, we provided suggestions to promote the development and improvement of teledentistry in the dental industry. Methods We conducted a descriptive cross-sectional study using an electronic survey in a sample of Chinese dental professionals. We designed 17 electronic questionnaires to evaluate the basic information of the dentists and four areas of perception in dentists: knowledge and attitude of the teledentistry, medical needs, teledentistry participation satisfaction and telemedicine use. We summarized the survey results using descriptive statistics and multivariate logistic regression analysis. Results 601 dental professionals participated in the study. 90.8% of dentists were aware of teledentistry, but only 51.7% agreed that teledentistry was effective in practice. The utilization rate of teledentistry was 59.1% in the previous year. The factors affecting teledentistry use were gender (OR=1.57, P<0.05), daily working hours (OR=1.86, P<0.05), level of knowledge (OR=2.50, P<0.05), consultation needs (OR=0.46, P<0.05), technology (OR=1.90, P<0.05) and network (OR=1.86, P<0.05). Conclusion Teledentistry should be combined with digital dental technology (e.g. 3D printing and CAD/CAM), visualization technology (e.g. VR/AR) and 5G technology to provide dentists with better technical standards and network transmission to help diagnose and treat patients. Simultaneously, we should pay attention to the associated factors such as understanding the degree of teledentistry, relevant demographic and sociological characteristics and working hours. Considering the current progress, we should optimize the process and efficiency in the teledentistry to increase its utilization among dentists.
The H9c2(2-1) cell-based sulforhodamine B assay is a non-animal alternative to evaluate municipal wastewater quality over time
Authors: Rodrigues Elsa T , Pereira Eduarda , Oliveira Paulo J , Pardal Miguel A 
Published: April 2022

Abstract
In the context of alternatives to animal testing, and since wastewater composition is highly variable, depending on time, day of the week and season, the present study validates the potential of the H9c2(2 − 1) cell-based sulforhodamine B (SRB) assay to evaluate the temporal variability of municipal wastewater. The impact of effluent disposal on water quality was also assessed using indicators of possible nutrient enrichment in the receiving water, and by determining ammonium, pH, chemical oxygen demand, total suspended solids and nine metal elements. Since rainwater can enter the municipal wastewater collection system and possibly alter toxicity, precipitation data was considered, as well as the number of new Covid-19 cases per week in the municipality. Moreover, the efficiency of the wastewater treatment process was evaluated as both raw influent and treated effluent samples were analysed. Results revealed that the H9c2(2 − 1) cell-based SRB assay appears to have an enormous potential to evaluate the temporal variability of municipal effluents, to discriminate influent and effluent toxic characteristics, as well as to study Covid-19 progression. We were able to trace the development of this pandemic by relating positive rates (wastewater may also reflect asymptomatic individuals), a crucial metric for understanding the development of a pandemic, with the selected alternative in vitro platform. Finally, the gathered results alerted to the impact of phosphates in the aquatic environment, leading us to recommend the inclusion of this parameter in regulatory assessments of wastewater discharges.
Polypyrimidine Tract-binding Protein 2 is a Potential Treated Target in Tg(SOD1*G93A)1Gur Mice
Authors: Xiong Zhenrong , Li Xinming , Yang Dejiang , Xiong Chongyu , Zhou Qi 
Published: April 2022

Abstract
The function of polypyrimidine tract-binding protein 2 (PTBP2) is the regulator of neuronal fate during central nervous system development. The possible relationship between the PTBP2 and the pathogenesis of amyotrophic lateral sclerosis (ALS) hasn’t been known. In this study, we observed and analyzed the expression and distribution of PTBP2, as well as the possible relationship between PTBP2 expression and distribution and the neural cell death in both SOD1 wild-type (WT) and Tg(SOD1*G93A)1Gur (TG) mice applying the immunofuorescence analysis and western blot analysis. Our data demonstrated that the PTBP2 expression and distribution significantly increased in the AH, the LH, and the surrounding CC region at the pre-onset, onset, and progression phases of ALS. PTBP2 protein isn't just expressed in mature neurons, yet additionally, in neuronal precursor cells, astrocytes, microglia. The increment of PTBP2 distribution was closely related to the death of neural cells at the development of ALS. PTBP2-expressing motor neurons were lost during the ALS disease process. Together, these results defined PTBP2 as a candidate therapeutic target for ALS, providing novel insights into mechanisms of vulnerability to motor neurons in ALS.
Curcumin Delivery by Mesoporous Silica Nanoparticles Capped by Chitosan Glycerol Phosphate Hydrogel: Characterization and Cytotoxicity Effects
Authors: Rashidi Ladan , Ganji Fariba , Asadian Mitra 
Published: April 2022

Abstract
In this work, mesoporous silica nanoparticles (MSNs) were synthesized and loaded by curcumin (MSNs-CU) and capped by chitosan glycerol phosphate hydrogel (CS/βGH/MSNs-CU). Both of CS/βGH/MSNs-CU and MSNs-CU were characterized and analyzed, then, the cell viability of epithelial breast tumor cells (MCF-7) and healthy primary human mammary fibroblasts (HPHMF) treated by these nanocarriers, free-CU and the CU dispersed in CS/βGH hydrogel were studied. The CU release of CS/βGH, CS/βGH/MSNs-CU, and MSNs-CU was studied in the simulated body fluid (SBF) and results showed CU release from CS/GP/CU, MSNs-CU and CS/βGP/MSNs-CU was 4, 13.19, 8.87% after 24h, respectively. Optimum loading and encapsulation efficiency percentages of CU into MSNs were obtained 25% and 99% in 24 h, respectively. The MTT assay showed MSNs, MSNs-CU, CU, CS/βGP, CS/βGP/CU, CS/βGP/MSNs-CU had no influence on HPHMF cells. Also, free-CU, MSNs-CU showed cytotoxicity in the concentrations upper than 100 µg/mL and 10 µg/mL against MCF-7 cells after 24h, respectively. No reduction of MCF-7 cell viability was observed in treated cells by CS/βGP/CU and CS/βGP/MSNs-CU after 24h or 48 h which can be attributed to trapping of CU in the cohesive network of hydrogel formed, thus, release of CU was so slowly in the treated cells or SBF.
Quality of life and pain perception among elderly people: a cross-sectional study with a tribal community population
Authors: Huang Chih-Yang , Ho Tsung-Jung , Chen Wan-Jing , Chen Jhong-Kuei , Zheng Sheng-Huai , Kao Hui-Chuan 
Published: April 2022

Abstract
Background
Elderly population has increased in worldwide and quality of life (QOL) become an crucial indicator to improve elders’ life. Pain perception as an important factor of QOL, but the impact on elderly population remains unclear.
Methods
This study aims to investigate the quality of life and pain perception of the elderly population at Tribal community based on care center in Hualien (Taiwan). This study involved a cross-sectional investigation and used Pain Verbal Rating Scale and WHO QOL-BREF Taiwan Edition survey pain perception and QOL according to the the questionnaire. ANOVA, Independent Sample t test and Chi-square test were used to investigate the differences between demographic variables and the QOL. Further, the correlation between pain perception and the QOL were assessed using Multiple Regression analysis.
Results
Subjects average age were 70.85 years old. Females, literate, no spouse or co-habitant and those who did not feel a good sleep quality were the majority. Most of the subjects reported mild pain in the previous months, and the average overall QOL score was 56.56 that suggested a moderate QOL for subject’s. There was a significant difference between pain perception and race; the overall QOL significantly varied depending on race, marital status, sleep quality and pain perception. The overall QOL regression model was correlated to race, marital status, pain perception and sleep quality, that explained the 15% explanatory variable of overall QOL. This study implicated that there exists significant differences in pain perception and QOL amongst dissimliar races and ethnicity. Ethnic groups represented as one of the confounding factors that modulated pain perception and QOL amongst elderly population. Besides, marital status, pain perception, sleep quality were significantly attributed to QOL.
Conclusion
Based on our findings, we suggest that different care measures based on above influencing factors should be considered to improve the QOL for elderly individuals.
Evaluation of the influence of posterior tibial slope on sagittal knee alignment on single-leg standing radiographs
Authors: Hiranaka Yoshiaki , Muratsu Hirotsugu , Tsubosaka Masanori , Matsumoto Tomoyuki , Maruo Akihiro , Miya Hidetoshi , Kuroda Ryosuke , Matsushita Takehiko 
Published: April 2022

Abstract
Posterior tibial slope (PTS) has been known to contribute to anterior-posterior knee stability and play an essential biomechanical role in knee kinematics. This study aimed to investigate the effect of PTS on single-leg standing sagittal knee alignment of the intact knee. This study included 100 patients with unilateral ACL injury knee (ACL injury group, 53 patients) or with the normal knee (control group, 47 patients). The single-leg standing sagittal alignment of the unaffected knees of the ACL injury group and normal knees of the control group were assessed radiographically with the following parameters: knee extension angle (EXT), PTS, PTS to the horizontal line (PTS-H), femoral shaft anterior tilt to the vertical axis (FAT), and tibial shaft anterior tilt to the vertical axis (TAT). PTS was negatively correlated with EXT and positively correlated with TAT. EXT was significantly larger in the ACL injury group, whereas TAT was smaller in the ACL injury group. Patients with larger PTS tend to stand with a higher knee flexion angle by tilting the tibia anteriorly, possibly reducing tibial shear force. Patients with ACL injury tend to stand with larger EXT, i.e., there is less preventive alignment to minimize the tibial shear force.