bluuebunny/crossref_metadata_2025_split huggingface dataset:
PD-1 induced-alveolar macrophages M1 polarization contributes to lung ischemia-reperfusion injury via SHP1/2-PI3K/Akt signaling
Authors: Lin Fei , He Xiaojing , Xiao Jingyuan , Lin Jinyuan , Liu Zhen , Liang Yubing , Dai Huijun , Jing Ren , Li Zhao 
Published: March 2022

Abstract
Background: Lung ischemia-reperfusion injury (LIRI) is a common and complex pathophysiological process. Activation of alveolar macrophages (AMs) is involved in the inflammatory response and tissue damage during LIRI. Programmed cell death factor-1 (PD-1) plays an important role in immunomodulatory participants in diseases progression by regulating apoptosis and polarization of macrophages. In this study, we investigated the function of PD-1 on macrophage polarization during pulmonary ischemia-reperfusion.Methods: We conducted experiments both in a rat model of lung ischemia/reperfusion injury and in NR8383 cells (a rat alveolar macrophage line) model of oxygen-glucose deprivation-reoxygenation (OGD/R). The extent of lung injury was measured by pathohistological lung tissue damage, wet/dry ratios of pulmonary tissue, levels of inflammatory factors. Western blot was used to detect the relative expression of PD-1, SHP1, SHP2, p-Akt, and Akt. Expression of surface markers on macrophages was measured by immunohistochemistry, flow cytometry, and immunofluorescence staining.Results: The results showed that the expression of PD-1 increased in both in vivo and in vitro models, which promoted the polarization of M1 macrophages, resulting in the aggravation of the pulmonary ischemia-reperfusion injury. These effects were at least partially attributable to PD-1 inhibiting the PI3K/Akt pathway by regulating SHP1/2. Conclusion: PD-1 may exacerbate LIRI by promoting macrophage polarization, and inhibition of PD-1 may be an important role and therapeutic target of acute lung injury.
Barriers to access prehospital care in Jimma City, Oromia Region of Ethiopia
Authors: Ibro Shemsedin Amme , Seid Sheka Shemsi , Akuma Adugna Olani , Haso Tura Koshe , Ahmed Abdulwahid Awol , Senbiro Ismael Ahmed , Moga Tolasa Takele , Fata Gutema Ahmed , Ahmed Muktar Beshir , Hebo Habtamu Jarso , Waga Sultan Suleman , Melkamu Gemechis , Reta Ebrahim Yimam , Chala Shimelis Legese , Lippi Matthew , Mould-Millman Nee-Kofi 
Published: March 2022

Abstract
Background: African nations experience a significant proportion of the global burden of death and disability. The provision of prehospital emergency care has been shown to partially reduce excess morbidity and mortality. However, access to prehospital care in Africa is still limited. This study sought to identify barriers to access prehospital care in the city of Jimma, Ethiopia.Methods: This is an interview-based qualitative study of key prehospital stakeholders in Jimma, conducted in February 2018. A purposive sample of individuals from the community and local ambulance organizations was selected for interviews. Interviews were conducted in local languages, translated into English, and then coded for consistent themes. Results: All respondents felt that prehospital care was difficult to access and therefore infrequently utilized. This was due to a combination of a limited number of ambulances, the lack of a toll-free emergency number, the lack of a single organized Emergency Medical Service (EMS) system, inconsistent and limited training of ambulance crews, public mistrust of the existing system, poor road infrastructure, and limited public understanding of the role of prehospital care. Respondents suggested that establishment of a formalized prehospital care system, investment in infrastructure, establishment of a toll-free emergency number, public awareness campaigns, and more widely available emergency medical training, which were feasible solutions to these current barriers to access.Conclusion: Multiple barriers to accessing prehospital care were identified in Jimma. Establishing a formalized, well-resourced prehospital system in parallel with improving community capacity and knowledge building were suggested solutions to improve access. Hence, interventions to improve prehospital emergency care delivery should ideally target these identified barriers and proposed solutions.
The Impact of an Employee’s Psychological Contract Breach on Compliance with Information Security Policies: Intrinsic and Extrinsic Motivation
Authors: Lee Daeun , Michaelides Nadine , Lallie Harjinder 
Published: March 2022

Abstract
Despite the rapid rise in social engineering attacks, not all employees are as compliant with information security policies (ISPs) to the extent that organisations expect them to be. ISP non-compliance is caused by a variety of psychological motivation. This study investigates the effect of psychological contract breach (PCB) of employees on ISP compliance intention (ICI) by dividing them into intrinsic and extrinsic motivation using the theory of planned behaviour (TPB) and the general deterrence theory (GDT). Data analysis from UK employees (n=206) showed that the higher the PCB, the lower the ICI. The study also found that PCBs significantly reduced intrinsic motivation (attitude and perceived fairness) for ICI, whereas PCBs did not moderate the relationship between extrinsic motivation (sanction severity and sanctions certainty) and ICI. As a result, this study successfully addresses the risks of PCBs in the field of IS security and proposes effective solutions for employees with high PCBs.
MUSE: An open-source agent-based integrated assessment modelling framework
Authors: Giarola Sara , Sachs Julia , d'Avezac Mayeul , Kell Alexander , Hawkes Adam 
Published: March 2022

Abstract

Integrated assessment models (IAMs) are a cornerstone of the climate change mitigation. Each IAM exhibits different methodologies for characterising the energy system, land use change, economics, and climate response. To date, no existing IAM can simulate the heterogeneity of investor or consumer decision-making in an integrated assessment context.This paper presents an open-source modelling framework designed to fill that gap. Named MUSE (ModUlar energy systems Simulation Environment), this new model supports flexible characterisation of agents’ decision-making, including imperfect foresight. It is modular, technology-rich, recursive-dynamic, and partial-equilibrium in nature. The structure of MUSE creates the ability to produce climate change mitigation assessments that are more grounded, and more tangible model outputs for conceiving effective approaches to mitigation.
Hilbert’s First Problem and the New Progress of Infinity Theory
Authors: Wang Xijia 
Published: March 2022

Abstract
In the 19th century, Cantor created the infinite cardinal number theory based on the "1-1 correspondence" principle. The continuum hypothesis is proposed under this theoretical framework. In 1900, Hilbert made it the first problem in his famous speech on mathematical problems, which shows the importance of this question. We know that the infinitesimal problem triggered the second mathematical crisis in the 17-18th centuries. The Infinity problem is no less important than the infinitesimal problem. In the 21st century, Sergeyev introduced the Grossone method from the principle of "whole is greater than part", and created another ruler for measuring infinite sets. At the same time, 16 the development of the infinity theory provides new ideas for solving Hilbert's first problem, and provides a new mathematical foundation for Cosmic Continuum Theory
SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation
Authors: Yuan Yuan , Zhou Danyang , Chen Feifei , Yang Zhenhua , Gu Wei , Zhang Kai 
Published: March 2022

Abstract
Increasing research has uncovered the involvement of long non-coding RNAs (lncRNAs) in the progression of multiple cancers including lung adenocarcinoma (LUAD). RT-qPCR and western blot were done to measure RNAs and proteins. Functional assays assessed LUAD cell biological behaviors under knockdown or overexpression of LINC01468, SIX5, SERBP1 or SERPINE1, and the specific function of those genes in regulating LUAD progression was evaluated via animal experiments. Supported by bioinformatics analysis, the interaction among genes was verified via mechanism assays. Upregulation of LINC01468 in LUAD tissues and cells as well as its association with poor clinical outcome was predicted. LINC01468, transcriptionally activated by SIX5, could strengthen proliferative, migratory and invasive abilities of LUAD cells. The oncogenic role of LINC01468 was further validated via animal experiments. SIX5 was a positive transcription regulator of LINC01468 and could exacerbate LUAD cell malignant behaviors. LINC01468 could recruit SERBP1 to enhance SERPINE1 mRNA stability and interact with USP5 to affect PAI1 protein ubiquitination. The oncogenic role of SERBP1 and SERPINE1 was also confirmed. Rescue experiments finally verified LINC01468 modulated proliferation, migration and invasion of LUAD cells via upregulation of SERPINE1. Our observations could contribute to deeper understanding of LUAD.
Independent and Joint Effects of Body Mass Index and Metabolic Health in Mid- and Late-life on All-Cause Mortality: A Cohort Study from the Swedish Twin Registry with a Mean Follow-up of 13 Years
Authors: Ler Peggy , Li Xia , Hassing Linda B , Reynolds Chandra A , Finkel Deborah , Karlsson Ida K , Aslan Anna K Dahl 
Published: March 2022

Abstract
Background
There is robust evidence that in midlife, higher body mass index (BMI) and metabolic syndrome (MetS), which often co-exist, are associated with increased mortality risk. However, late-life findings are inconclusive, and few studies have examined how metabolic health status (MHS) affects the BMI–mortality association in different age categories. We, therefore, aimed to investigate how mid- and late-life BMI and MHS interact to affect the risk of mortality.
Methods
This cohort study included 12,467 participants from the Swedish Twin Registry, with height, weight, and MHS measures from 1958—2008 and mortality data linked through 2020. We applied Cox proportional hazard regression with age as a timescale to examine how BMI categories (normal weight, overweight, obesity) and MHS (identification of MetS determined by presence/absence of hypertension, hyperglycemia, low HDL, hypertriglyceridemia), independently and in interaction, are associated with the risk of all-cause mortality. Models were adjusted for sex, education, smoking, and cardiovascular disease.
Results
The midlife group included 6,252 participants with a mean age of 59.6 years (range = 44.9—65.0) and 44.1% women. The late-life group included 6,215 participants with mean age 73.1 years (65.1—95.3) and 46.6% women. In independent effect models, metabolically unhealthy status in midlife increased mortality risks by 31% [hazard ratio 1.31; 95% confidence interval 1.12–1.53] and in late-life, by 18% (1.18;1.10–1.26) relative to metabolically healthy individuals. Midlife obesity increased the mortality risks by 30% (1.30;1.06–1.60) and late-life obesity by 15% (1.15; 1.04–1.27) relative to normal weight. In joint models, the BMI estimates were attenuated while those of MHS were less affected. Models including BMI-MHS categories revealed that, compared to metabolically healthy normal weight, the metabolically unhealthy obesity group had increased mortality risks by 53% (1.53;1.19—1.96) in midlife, and across all BMI categories in late-life (normal weight 1.12; 1.01–1.25, overweight 1.10;1.01–1.21, obesity 1.31;1.15–1.49). Mortality risk was decreased by 9% (0.91;0.83–0.99) among those with metabolically healthy overweight in late-life.
Conclusions
MHS strongly influenced the BMI-mortality association, such that individuals who were metabolically healthy with overweight or obesity in mid- or late-life did not carry excess risks of mortality. Being metabolically unhealthy had a higher risk of mortality independent of their BMI.
Generalized Backward doubly SDEs driven by Lévy processes with discontinuous and linear growth coefficients
Authors: Owo Jean-Marc , Aman A. 
Published: March 2022

Abstract
This paper deals with generalized backward doubly stochastic differential equations driven by a Lévy process (GBDSDEL, in short). Under left or right continuous and linear growth conditions, we prove the existence of minimal (resp. maximal) solutions.MSC:Primary: 60F05, 60H15; Secondary: 60J30
Nitrosodiethylamine removal performance of modified activated carbon
Authors: Lu Jiangang , Cai Haisheng , Fu Yanmei , Shi Xianluo 
Published: March 2022

Abstract
This paper discusses the preparation of modified activated carbon (PAC-1) and its adsorption performance for nitrosodiethylamine (NDEA). The PAC-1 was characterized by SMS and X-ray diffractometer, and its NDEA removal mechanism was investigated. The results showed that, compared with unmodified activated carbon, PAC-1 had a better adsorption effect for NDEA after pre-soaking with 0.8 mol/L permanganate (PM) for 24 hours and calcination at 400 °C for 7 hours. Under the conditions of 8 g/L PAC-1 dosage, pH = 6, and adsorption time of 6 h, the adsorption rate of NDEA with an initial concentration of 50 mg/L reached 78.66%, the maximum equilibrium adsorption capacity was 4.916 mg·g−1, and the adsorption rate of unmodified activated carbon to NDEA was increased by 42.5%. The number of oxygen-containing surface functional groups of activated carbon was increased after permanganate prepreg, which can enhance the NDEA adsorption rate. The adsorption process of NDEA on modified activated carbon conforms to pseudo-second-order kinetics, and the adsorption isotherm corresponds to the Freundlich model.
Hesperidin Exerts Anxiolytic-like Effects in Rats with Streptozotocin‐
Induced Diabetes via PKA/CREB Signaling
Authors: Yin Xiaoxing , Zhu Xia , Liu Haiyan , Deng Zongli , Yan Chuanzhi , Liu Yaowu 
Published: March 2022

Background:
The mechanisms underlying synaptic injury and anxiety-like behavioral changes caused by diabetes and the strategies to reverse these changes are not well understood.

Objectives:
This study examined the neuroprotective effects of hesperidin on anxiety-like behav-iors in diabetic rats and investigated the underlying mechanisms from the perspective of the PKA/CREB pathway.

Methods:
Rats with streptozotocin-induced diabetes were treated orally with hesperidin (50 and 150 mg/kg) for 10 weeks. The elevated plus maze (EPM), hole board test (HBT), and marble-burying test (MBT) were used to assess anxiety-like behaviors. We further examined the effects of hesperidin on the PKA/CREB pathway in vivo and in vitro.

Results:
The results show that supplementation with hesperidin exerted anxiolytic effects on the diabetic rats, as evidenced by increased percentages of open arm entries and time spent in the open arms in the EPM; decreased numbers of hole visits in the HBT; decreased numbers of marbles buried; and increased expression of PKA, CREB, BDNF, and synaptic proteins in the amygdala and hippocampus of diabetic rats. Hesperidin was found to reverse the imbalance in the PKA/CREB/BDNF pathway. In vitro, we found that the PKA inhibitor H89 reversed the protective effects of hesperidin against cell injury and reversed the HG-induced expression of PKA, pCREB/CREB, and BDNF.

Conclusion:
Our results demonstrated that hesperidin could ameliorate the anxiety-like behaviors of diabetic rats and that activating the PKA/CREB/BDNF pathway contributed to the beneficial effects. This study may provide important insights into the mechanisms underlying anxiety-like behaviors in diabetes and identify new therapeutic targets for clinical treatment.
Exercise in Older Adults to Prevent Depressive Symptoms at the Time of Covid-19: Results of a Randomized Controlled Trial with Follow-Up
Authors: Carta Mauro Giovanni , Aviles Gonzalez Cesar Ivan , Minerba Luigi , Pau Massimiliano , Musu Mario , Velluzzi Fernanda , Ferreli Caterina , Pintus Elisa , Machado Sergio , Romano Ferdinando , Vacca Veronica , Preti Antonio , Cossu Giulia , Atzori Laura 
Published: March 2022

Background:
This study aimed to verify, through a randomized controlled trial, whether a medium-intensity mixing/aerobic/anaerobic exercise (accessible to older adults even with mild chronic diseases) can effectively counteract depressive episodes. A characteristic of the trial was that the follow-up coincided (unscheduled) with the lockdown due to Covid-19.

Methods:
Participants (N=120) were randomized into an intervention group, performing physical exercise, and a control group. Participants, aged 65 years and older, belonged to both genders, living at home, and cleared a medical examination, were evaluated with a screening tool to detect depressive episodes, the PHQ9, at pre-treatment, end of the trial (12-week), and follow-up (48-week).

Results:
A decrease in the frequency of depressive episodes after the trial (T1) was found in both groups; however, a statistically significant difference was observed only in the control group (p=0.0039). From T1 to follow-up (conducted during the lockdown), the frequency of depressive episodes increased in the control group, reaching a frequency equal to the time of study entry (p=0.788). In the experimental group, the frequency of depressive episodes did not change at the end of the trial but reached a statistically significant difference compared to the start of the study (p = 0.004) and was higher than the control group (p=0.028).

Conclusion:
Moderate-intensity physical exercise can be conducted safely, benefitting older adults even suffering from mild chronic disorders. Physical exercise seems to guarantee a long-term preventive effect towards depressive symptoms, especially in serious stressful situations such as the lockdown due to the Covid-19 pandemic.

Clinical Trial Registration Number (NCT03858114)
Reflections on the Centenary of Sir William Osler: Science and Humanity are One, for Nursing and Medicine
Authors: Ryan Terence J. , Ersser Steven J. , Galvin Kathleen , Malone Mary , Markwell Sally , Shaw Theresa 
Published: March 2022

Sir William Osler (1849-1991) was Regius Professor of Medicine at the University of Oxford in the UK and a founding professor at Johns Hopkins Hospital. The centenary of Osler’s death is a time for recognition in nursing, as well as medicine, of a pioneering and highly influential Oxford physician on both sides of the Atlantic, an influence that extended to nursing from the UK to the USA.
This letter captures reflections and discussion on contemporary nursing issues from an Osler Seminar Series, held at the University of Oxford in 2019 to mark the Centenary of Sir William Osler’s death, focusing on his thinking and influence related to nursing.
This extended letter illuminates issues on themes of science and humanity within a clinical and educational context, exploring a range of key contemporary nursing issues. These include the significance of interpersonal relations as they relate to care attitude and care technology; the therapeutic influence of the nurse; nursing education and clinical-academic development; the value of a life world perspective on nursing and wellbeing; and practice development within the context of person-centred workplace cultures. These issues are contextualised with examples from practice and include some from nursing developments and those illustrated in part by the clinical speciality of dermatological care.
The letter concludes by considering the significance of the nursing service to promoting access to quality health care in the twenty-first century and its relevance to recognising the nursing contribution to universal health care through the WHO International Year(s) of the Nurse and Midwife in 2020-21.
Platelet Count and IgE Level in Chronic Idiopathic Urticaria: A Case-control
Study
Authors: Kalmarzi Rasoul Nasiri , Ahmadiniaz Mobin , Ataee Pedram , Babaei Erfan , Khalafi Behzad , Kooti Wesam , Darehbagh Ramyar Rahimi 
Published: March 2022

Background and Aim:
Chronic Urticaria is an allergic disorder that affects about 0.5 to 5% of the population in different communities. The disease's chronic course and long-term onset impose high economic and psychological costs on communities, adversely affecting individual and social life. Platelets play a role in various pathophysiological processes, including inflammation and immunol-ogy. Growing evidence suggests that platelets are actively involved in the pathogenesis of various inflammatory disorders, including inflammatory skin diseases. This study investigated the relationship between platelet and immunoglobulin-E markers and chronic idiopathic urticaria.

Materials and Methods:
In the present case-control study, for the study population, patients with chronic idiopathic urticaria were referred to the Asthma and Allergy Clinic, and their caregivers were selected as the case and control groups, respectively. In this study, the mean platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and Total IgE values were simulta-neously measured in the case and control groups. After taking 5CCs of venous blood, a blood sample was sent to the laboratory for platelet and IgE marker measurements.

Results:
100 patients and 100 healthy persons were evaluated in this study. The mean age in the case group was 34.95, and in the control group was 35.78 years. The results showed that the mean values of PLT, MPV, PDW, and Total IgE in the case group were 12.86, 9.83, 252190, and 147.05, respec-tively. The mean values of PLT, MPV, PDW, and Total IgE in the control group were 16.93, 7.53, 231410, and 15.29, respectively, which was statistically significant (P = 0.001). Moreover, total IgE in the Autologous Serum Skin Test (ASST) positive group was higher than ASST negative group and was statistically significant (P = 0.001).

Conclusion:
The study results indicate the possible role of platelets in urticaria and inflammation. MPV in patients with chronic urticaria was higher than in the control group. The present study showed no significant relationship between the severity of urticaria and platelet markers, but there was a sig-nificant relationship between the severity of urticaria and ASST. Moreover, the severity of urticaria was higher in the positive skin test group.
THE FUNCTION OF WAREHOUSE IN ELEVATED SUPPLY CHAIN: (The case study of farmer’s shallots in East Java)
Authors: Hermawan La Ode Andi , Prasetya Arik , Worokinasih Saparila 
Published: March 2022

PurposeÂ â€” This research aims to evaluate the function of the warehouse in increasing the supply chain of shallot production in East JavaÂ Design/methodology/approachÂ -Â This research uses explanatory research with a quantitative approach. The object of this research was in four districts of East Java at Nganjuk, Kediri, Malang, and Probolinggo which are the centers of shallot production that have similar environmental conditions. The sampling method in this research used multistage proportional random sampling with 200 respondents as a sample of this research. Data analysis uses the path analysis method by software SEM PLS Software 3.0.Â FindingsÂ -Â The results show that the warehouse has a significant effect on the integrative supply chain variable, the warehouse has no significant effect on the performance Effort variable and the integrative supply chain has a significant effect on the performance efforts variable.Practical Implications -Â Supply Chain Improvement is greatly influenced by theÂ warehouseÂ but not by performance Efforts.Originality/valueÂ -Â The key aspect of this research is increasing the effectiveness of warehouse operations in the logistics system and integrated supply chain activities as well as improving the performance of businesses focused on horticulture by approaching farmers and partners (traders). This study expands the literature on the function of warehouse utilization in Supply Chain activities so that it has an impact on improving business performance.Keywords:Â Warehouse, Supply Chain Integration, Performance Efforts