bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationale and design of COLchicine On-admission to Reduce inflammation in Acute Coronary Syndrome (COLOR-ACS) study
Authors: Toso Anna , Leoncini Mario , Magnaghi Gaia , Biagini Francesco , Martini Olimpia , Maioli Mauro , Villani Simona , Comeglio Marco , Bellandi Francesco 
Published: December 2022

Aims
The aim of the colchicine on-admission to reduce inflammation in acute coronary syndrome (COLOR-ACS) study is to evaluate the effects of the addition of short-term, low-dose colchicine to high-dose atorvastatin in limiting levels of inflammatory markers, such as high-sensitivity C-reactive protein (hs-CRP), in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS).

Methods
The COLOR-ACS study is a multicenter, randomized, open-label, two-arm trial. Statin-naive patients with NSTE-ACS, scheduled for an early invasive strategy, are randomized on admission to receive standard treatment of atorvastatin 80 mg or standard treatment plus colchicine (1 mg loading dose followed by 0.5 mg/day until discharge). The main exclusion criteria are prior statin and/or colchicine treatment, current treatment with potent inhibitors of CYP3A4, P-glycoprotein or immunosuppressive drugs, known active malignancy, severe kidney, cardiac, liver disease. There is clinical and biochemical follow-up at 30 days after discharge and telephone interview at 6 months. The primary end point is the change in hs-CRP from admission to discharge. Secondary end points include: incidence of acute kidney injury; MB fraction of creatine kinase peak value; glomerular filtration rate change from baseline to 30 days; persistence of hs-CRP ≥2 mg/dl at 30 days; adverse clinical events within 30 days; tolerance to colchicine.

Conclusion
The COLOR-ACS study will provide evidence on the efficacy of early short-term treatment with colchicine in addition to high-dose atorvastatin compared to atorvastatin alone in ACS patients. The potential anti-inflammatory action of colchicine plus atorvastatin is expected to limit hs-CRP increase with resultant clinical benefits.

Trial registration
ClinicalTrials.gov; NCT05250596.
Changes of Urban Food Purchase Habits during the First Wave of COVID-19: Hungarians Living in Romania and Hungary Compared
Authors: György Ottilia , Orbán Endre 
Published: December 2022

Abstract
The outbreak of the COVID-19 epidemic in 2020, the emerging economic uncertainty, a declining trust, digital solutions, and the home office have changed consumer behaviour, including food-buying habits. Given that the epidemic in Central and Eastern Europe has developed differently due to territorial differences, we have focused our study on the comparative analysis of two countries. The aim of our research was to examine the food purchase habits during the first wave of the pandemic together with consumer decisions and their motivations emerged due to the epidemic among the Hungarian urban population of two countries. In the present study, we conducted a survey among Hungarian urban consumers in Romania and among the urban population in Hungary at the beginning of the pandemic when lockdown was implemented. Over a two-month period, we collected more than 2,000 completed questionnaires.
The Dilemmas of the Post-War Transition for the Transcarpathian Calvinists in the Soviet Empire (1944–1949)
Authors: Szamborovszky-Nagy Ibolya 
Published: December 2022

Abstract
The present study examines the dilemma of the Calvinists living in Transcarpathia (which became part of the Soviet Union in 1946) that arose following its annexation to the Soviet Empire. The problem was caused by the fact that among the Protestant denominations in the Soviet Union in 1946-47, only Evangelical Christians-Baptists (ECB) had state registration, i.e. a legal operating licence. The study aims at revealing the dialectics of the dilemma arising among the Calvinists, according to which, in order to survive, they should either align with the ECB (i.e. imperial expectations) or, alternatively, even take the risk of termination and maintain their denominational separation. In addition, the research brings insights into how the choice of the Calvinists was influenced by the denominational autonomy and national traditions that had been enjoyed until then. The state authorities would have provided a chance for an easier and routine-like solution of the problem and classify the nearly 80,000 Reformed community members in Transcarpathia as ECB. However, the case generated an unexpected problem even in the Soviet bureaucratic system as the denominational affiliation was also linked to the issue of nationality. Therefore, at the state level, it was a problem of both a religious belief and national belonging. Likewise, the study highlights the extent to which the response of the religious minority in the present case was about religious affiliation and ethnicity. Finally, the present paper considers how the state’s primary project had ultimately changed when exploring the dilemma and what conclusions and outcomes it entailed.
Computer Geometric Modeling Approach with Filament Assembly Model for 2 × 1 and 3 × 1 Twill Woven Fabric Structures
Authors: Patumchat Puttipong , Inthidech Sudsakorn , Srithep Yottha , Sriprateep Keartisak 
Published: December 2022

Abstract
A new computer geometric modeling approach for 2 × 1 and 3 × 1 twill woven fabric structures is proposed. The precise geometrical description is presented by taking the skewness property into account. In the 2 × 1 and 3 × 1 twill weaves, the twill fabrics are formed of asymmetric floatings in which the length of floating sections was not equal on both surfaces and therefore the equilibrium condition was different from symmetric floatings. The proposed algorithm has three main parts: the first part describes the two-dimensional model of yarn cross-section for twill woven fabric structure, the second part consists of a modeling method for a three-dimensional model in warp/weft yarn, and the third part contains the CAD model. Examples of this approach are demonstrated and compared with a single line of yarn path model and the filament assemble model that excludes the skewness property. The model simulated in this study can improve the visual simulation of the real twill woven fabric and also this geometric model necessary as an input to many computational models for the prediction of the properties of the fabrics.
Philosophical and geopolitical resources for ethical justification of the national and state revival of the suppressed nations in Central Europe
Authors: Bednář Miloslav 
Published: December 2022

Abstract
This reflection examines the context of philosophical-ethical research and its preceding and continuing particular geopolitical framework in the central zone of Central Europe in the case of the national and state revival of the Czech nation. It focuses on the work and endeavour of František Palacký and its interpretive development by Thomas Garrigue Masaryk, which resulted in the foundation of the Czechoslovak Republic. In this context, it finally outlines the significance of the dramatic Central European affairs since the turn of 1989 to the Russian war on Ukraine.
The distributional impact of the Sierra Leone conflict on household welfare
Authors: Reilly Barry , Sam Hannah 
Published: December 2022

Abstract
This study examines the impact of the Sierra Leone civil war on household expenditure inequality. The paper exploits three rounds of household survey data for Sierra Leone in an attempt to estimate the impact of the conflict on the distribution of household welfare over both short-run and long-run periods. The empirical approach uses RIF measures based on the Gini index and also provides estimates of treatment effects at selected quantiles of the unconditional household expenditure distribution. The key findings reveal that localities subject to a protracted period of occupation by rebel forces experienced a sharp reduction in household expenditure inequality in the immediate aftermath of the conflict with most of the contraction evident at the top end of the distribution.
Site-Directed Mutagenesis – A Chance to Meet Environmental Challenges and Provide Healthy Food for People or an Unacceptable Hazard to Humans, Animals, and the Environment. Consequences of the European Court of Justice Judgment in Case C-528/16
Authors: Michalczuk Lech 
Published: December 2022

Abstract
One of the EU's strategic goals is to reduce the environmental and climate footprint of the EU food system and strengthen its resilience, while ensuring food security for European citizens. Thus, the EU Farm to Fork strategy, which is one of the central pillars of the European Green Deal, set ambitious targets for 2030 to reduce pesticide use in agriculture by 50% and fertilizers use by 20%, with a concomitant 50% reduction of nutrient leakage to surface and groundwater. Additionally, it is recommended that at least 25% of the EU agricultural land shall be kept under organic farming. These goals are far-reaching, but several recent studies indicate that implementing them without significant progress in research and innovation (R & I) may result in a yield decrease by up to 30%, depending on the crop, and an increase in the price of agricultural commodities by up to 18%. Especially affected would be horticulture due to its high dependence on plant protection against pests and diseases. Therefore, the studies recommend accelerating plant breeding in order to produce new plant cultivars genetically resistant to pests and diseases and better equipped to cope with abiotic stresses like limited nutrition and water deficit. The progress in classical plant breeding is a lengthy process. It is especially slow in the case of woody species, like most fruit plants, due to their long juvenile periods and limited genetic variance. Recent advances in functional genomics, bioinformatics, and molecular methods provided tools that speed up the breeding process significantly. Several site-directed mutation technologies allow modifying a specific gene at a predefined site, by deletion or insertion of single or multiple nucleotides, without affecting off-target genes. Several valuable cultivars have been bred so far using these methods, and a large number of others are under trials. However, their release will be severely impeded by the decision of the Court of Justice of the European Union, dated 25 July 2018, that the release of organisms obtained by site-specific mutations, as opposed to organisms obtained by induced random mutation, is controlled by Directive 2001/18/EC2 on genetically modified organisms. This paper reviews the new generation breeding techniques, especially site-directed mutagenesis, and their benefits as well as potential hazards to consumers and the environment.
How Alcohol Damages Brain Development in Children
Authors: Pop-Jordanova Nada , Demerdzieva Aneta 
Published: December 2022

Abstract
The world over, people drink in order to socialize, celebrate, and relax, despite the negative health effects of alcohol. Three periods of dynamic brain changes are evidenced to be particularly sensitive to the harmful effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). This article is concentrated only on the negative effects of alcohol in children who have been exposed to alcohol before birth, known as foetal alcohol syndrome (FAS).
This is a review based on published data in PubMed over the last two decades and is an analysis of more than 150 published papers.
Alcohol use during pregnancy can cause miscarriage, stillbirth, and a range of lifelong physical, behavioural, and intellectual disabilities. The effects of ethanol are expressed on a set of molecules involved in neuroinflammation, myelination, neurotransmission, and neuron function.
Modern neuroimaging techniques are able to specify some fine structural changes in the affected areas of the brain: volume reductions in the frontal lobe, including the middle frontal gyri in the prefrontal cortex, hippocampal structure, interhemispheric connectivity, abnormalities in glial cells, white matter deficits etc. Corpus callosum myelination is affected, resulting in a lack of the inter-hemispheric connectivity. This is known to facilitate autism, stroke, schizophrenia, as well as dementia, disrupts cognitive performance, and may lead to neurobehavioral deficits.
It was pointed out that many symptoms and neuroimaging characteristics are similar in ADHD and FAS, thus the anamnesis for prenatal alcohol and nicotine exposure must be taken very seriously in order to better understand and interpret clinical symptoms.
Percutaneous Nephrostomy in the Treatment of Hydronephrosis in Renal Transplant Patients – Case Report
Authors: Severova Galina , Karanfilovski Vlatko , Nikolov Igor , Dzekova-Vidimliski Pavlina , Rambabova-Bushljetik Irena , Dohcev Sasho , Spasovski Goce 
Published: December 2022

Abstract
Percutaneous nephrostomy is a first-line minimal invasive treatment option for ureteral obstruction following kidney transplantation, with high effectiveness and a low complication rate. Percutaneous nephrostomy might be used as a temporary salvage therapy, providing acute decompression of the kidney collecting system and preventing graft loss. It can also function as a permanent and sometimes only possible option in transplant patients with frequent recurrences of ureteral stenosis who either fail an open surgical reconstruction or who are not good candidates for these procedures. We present two patients with acute decline in urine output after renal transplantation with radiologically verified hydroureteronephrosis of the transplanted kidney (graft) caused by stenosis of distal ureter. In both cases, nephrostomy was placed within 48 hours as a temporary salvage treatment that ameliorates renal function and prevents graft loss. The permanent nephrostomy was the only possible solution for the preservation of the graft’s function in the first case because of the recurrences of ureteral stenosis after several percutaneous interventions and open-surgery ureteral reconstruction. A few episodes of nephrostomy tube-related infections were resolved with antibiotics in the first case. The second case was treated with open ureteroneocystostomy with resection of stenotic segment and reinsertion of the ureter into the bladder (ureterocystoneostomy) because of the length of the involved ureteral segment. Both patients had stable graft function in the follow-up period.
Management of Polyneuromyopathy in a Critically Ill Patient with a Left Ventricular Assist Device
Authors: Savevska Cvetanka Gjerakaroska , Radovikj Marija Gjerakaroska , Gechevska Daniela , Koevska Valentina , Mitrevska Biljana , Gocevska Marija , Matjanoska Lidija Stojanoska , Ivanovsk Biljana Kalcovska , Manoleva Maja 
Published: December 2022

Abstract
Critical illness polyneuromyopathy after cardiac surgery is often unrecognized and is a rarely reported clinical condition. It is characterized by more proximal than distal symmetrical flaccid muscle weakness and difficulty in weaning from a respirator. When done in a timely manner, rehabilitation prevents early complications and reduces the length of hospitalization. Rehabilitation leads to better motor outcome, improves short-term and long-term functionality, and results in a better quality of life.
Endangered Languages: A Sociocognitive Approach to Language Death, Identity Loss, and Preservation in the Age of Artificial Intelligence
Authors: Low Dylan Scott , Mcneill Isaac , Day Michael James 
Published: December 2022

Summary
Sociolinguists suggest language death entails significant cultural, personal, and ecological loss. Socio-cultural and socio-political factors exacerbate language erosion and encourage supplantation by another more dominant language. Hence, we ask: what are the sociocognitive principles which make language death hurtful and symbolic? Within this article, we attempt to outline a sociocognitive account of language death, situating the Hallidayan perspective of language as a “social-semiotic” system alongside a Cognitive Linguistic approach. We further contextualise language as inseparable from culture, drawing insight from the sociological thought of Bourdieu. We contend that language death entails psychological trauma, representing the destruction of cultural genealogy and the loss of knowledge intrinsic to personal self-imagery and identity. To this end, we present a case study of the Māori languaculture in Aotearoa (New Zealand), tracing the impact of colonialism and marginalisation to current efforts and ambitions to ensure the languacultural survival of Māori and reclaim space in Aotearoa as a respected knowledge system and means of expression, particularly in the socio-technical age of artificial intelligence (AI) and the Web. We argue that our analysis bodes practical implications for language maintenance and revitalisation, concluding that sociolinguistic practitioners should consider a socio-cognitivist as well as socio-technical paradigm for language intervention. In closing, we discuss leveraging AI technologies towards language heritage, archival, and preservation to limit the destructive impact of the death of a language.
Identity Formation and Career Prospects of Bilingual Professionals: Blending Language Skills to Create Novel Applications to Career Pursuits
Authors: Ural Onur , Dikilitas Kenan 
Published: December 2022

Summary
The most widely believed misconception about bilingualism purports that exposure to a second language within the community will automatically yield bilingual children, who can apply their balanced language skills in every domain of their future employment. However, this misconception does not represent the real-life experiences of most bilinguals. Through a pivotal focus on individual cases, this study was designed to manifest (1) bilingual identity formation and (2) career prospects of early and sequential bilinguals. The study analyzed collected data from individual surveys and in-person interviews with bilingual professional adults. Findings revealed that conscious engagement with the languages they were exposed to as children plays an active role in a bilingual speaker’s identity formation process and influences their career pursuits, instead of the common notion that being exposed to a second language is adequate to embrace bilingualism. Hence, this article brings implications to consider on career pursuits of bilingual speakers as the results indicate bilingual career pursuits transcend language-related occupations.
The Use of Digital Tools in Pre-Service Teachers’ Professional Development Towards Linguistic Diversity in Primary Education
Authors: Smeins Engelina Maria , Wildenburg Kirsten , Duarte Joana 
Published: December 2022

Summary
As language diversity in education gradually increases, several challenges for primary school teachers arise. According to previous studies, there are not many adequate teacher training programs that prepare teachers in linguistically diverse classrooms and, therefore, teachers that teach pupils with linguistically/culturally diverse backgrounds highly depend on their own engagement with plurilingualism. This shows the need for initial plurilingual(-oriented) pre-service teacher training and in-service teachers’ continuing professional development that focus on acquiring language awareness and obtaining strategies for promoting and recognizing linguistic diversity in the classroom. In addition, most teachers feel the need for further professionalization and tools to help them manage and acknowledge the diversity in their classrooms. Through a pre-post-intervention design, this study examined a) the effects of digital tools for teacher professionalization for plurilingual education on pre-service teachers’ attitudes and knowledge, and (b) how AR-games can be used to further language awareness and openness towards plurilingualism of pre-service teachers and their pupils. The participants reported that the digital tools contributed to their knowledge of linguistic diversity in the classroom, as well as ways to implement plurilingualism in their teaching practices and further language awareness.
Suara Rang Awak: Radio Jam Gadang, Bukittinggi Pasca Reformasi
Authors: Dayaning Buana Fadila , Samry Wannofri 
Published: December 2022

Objek penelitian ini adalah Radio Jam Gadang FM, salah satu radio swasta di Bukittinggi. Radio ini lahir untuk mempertahankan dan memperkuat identitas Minang ketika gencarnya aliran globalisasi dan modernisasi yang banyak disiarkan media massa pada awal reformasi. Pengumpulan data menggunakan metode wawancara, dokumentasi, arsip dan observasi lapangan. Sumber dan informasi yang didapat dari studi pustaka dan wawancara dikritik lalu diinterprestasikan, kemudian dilakukan penulisan sejarahnya. Hasil penelitian ini mengungkapkan bahwa radio Jam Gadang telah menyuarakan identitas Minangkabau di kota Bukittinggi. Seluruh programprogram yang disajikan pada radio Jam Gadang memiliki tujuan sebagai wadah untuk melestarikan kesenian Minangkabau di tengah masyarakat urban.
Kata kunci: radio, identitas, Minangkabkau, globalisasi, modernisasi
ANALISIS TREN PERKEMBANGAN KINERJA INVESTASI ASING MENURUT BIDANG USAHA SEBELUM DAN SESUDAH PANDEMI COVID 19 DI JAWA TIMUR
Authors: Sutarmin  , Sugiyanto  , Budiarti, MM Dra. Wiwik 
Published: December 2022

Penelitian ini bertujuan untuk menganalisis tren perkembangan kinerja investasi berdasarkan bidang usaha sebelum dan sesudah pandemi covid 19. Analisis dilakukan dengan membandingkan laju pergerakan Investasi Asing periode 2016 sampai dengan 2021 berdasarkan bidang usaha yang dilakukan di Jawa Timur. Data dikumpulkan melalui dokumentasi, kemudian dilakukan display data yaitu menyusun data, kemudian dilakukan penyerderhanaan sesuai kebutuhan data; langkah selanjutnya adalah penyajian data dalam bentuk gambar, kemudian melakukan Intepretasi data perbandingan dan langkah terakhir adalah merumuskan kesimpulan dan memberikan rekomendasi. Kinerja investasi asing tahun 2016 di Jawa Timur terhadap kinerja nasional memberikan kontribuii Rp26,57 trilliun dari Rp396,64 trilliun atau sebesar 6,70%. Pada tahun 2017 kinerja Jawa Timur terhadap investasi asing secara nasional memberikan kontribuii Rp20,93 trilliun dari Rp430,46 trilliun atau sebesar 4,86%. Pada tahun 2018 mengalami penurunan bila dibandingkan tahun sebelumnya, kinerja investasi asing Jawa Timur secara nasional memberikan kontribuii Rp17,87 trilliun dari Rp392,73trilliun atau sebesar 4,55%. Pada tahun 2019 mengalami penurunan bila dibandingkan tahun sebelumnya, kinerja investasi asing Jawa Timur tahun 2019 secara nasional memberikan kontribusi Rp12,99 trilliun dari Rp4223,13 trilliun atau sebesar 3,07%. Namun mulai tahun 2020 mengalami kenaikkan kinerja investasi asing Jawa Timur secara nasional memberikan kontribuii Rp22,69 trilliun dari Rp412,79 trilliun atau sebesar 5,50%. Dan tahun 2021 juga mengalami peningkatan nilai investasi sebesar Rp27,00 trilliun dari Rp453,96 trilliun atau sebesar 5,95%. Sehingga dapat di simpulkan bahwa dari hasil analisis, tahun 2019, 2020 dan 2021 menunjukkan bahwa kontribusi Jawa Timur pada masa covid 19 justru menunjukkan peningkatan yang cukup signifikan
Recency Matematis Mahasiswa Calon Guru Matematika dalam Menyelesaikan Masalah Bergambar
Authors: Darmawan Puguh , Yohanes Barep 
Published: December 2022

Recency merupakan suatu pengambilan kesimpulan yang didahului oleh kejadian sejenis. Recency sangat penting bagi mahasiswa calon guru matematika karena untuk menghindari kesalahan berpikir/ bias kognitif. Penelitian ini merupakan penelitian kualitatif yang bertujuan untuk mengetahui munculnya recency positif dan recency negatif pada mahasiswa calon guru matematika. Penelitian dilakukan dengan memberikan masalah bergambar bagi mahasiswa calon guru matematika dan berdasarkan indikator dikelompokkan dalam recency positif dan recency negatif. Hasil penelitian menunjukkan bahwa mahasiswa yang mengalami recency positif terjadi karena pengalaman belajar dan kejadian serupa yang diyakini. Recency negatif terjadi karena pengalaman belajar dan kejadian serupa yang diragukan.
Kata Kunci: recency matematis, mahasiswa calon guru, masalah bergambar, peluang