bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of anesthetics on postoperative nausea and vomiting after peripheral vascular surgery in end-stage renal disease patients: A retrospective observational study
Authors: Cho Ho Bum , Park Sun Young , Chung Ji Won , Koo Wan Mo , Choi Sang Jin , Song Sanghoon , Yoo Jae Hwa , Kim Mun Gyu 
Published: May 2022

Abstract
Propofol-based total intravenous anesthesia (TIVA) is considered a prophylactic approach to decrease postoperative nausea and vomiting (PONV). Despite general anesthesia commonly being performed in end-stage renal disease (ESRD) patients, PONV in ESRD patients has not been well-described. We investigated PONV in peripheral vascular surgery under general anesthesia in ESRD patients. To compare PONV between propofol-based TIVA and anesthesia with volatile anesthetics, we collected retrospective data from patients who underwent peripheral vascular surgery under general anesthesia from July 2018 to April 2020. We performed univariable and multivariable analyses, including factors that could be associated with PONV and those previously shown to affect PONV. A total of 1,699 peripheral vascular surgeries under general anesthesia in ESRD patients were eligible for analysis. Based on the multivariable analysis, TIVA (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.35–0.60; P < 0.001) significantly decreased PONV. Female sex (OR, 1.85; 95% CI, 1.44–2.38; P < 0.001) and anesthetic duration (OR, 1.01; 95% CI, 1.00–1.01; P < 0.001) were associated with increased PONV. Propofol-based TIVA is the most influential factor decreasing PONV after peripheral vascular surgery in ESRD patients. Anesthesiologists can apply propofol-based TIVA as an alternative to anesthesia with volatile anesthetics.
Regorafenib with or without a programmed cell death protein 1 antibody as third-line treatment for microsatellite stable metastatic colorectal cancer
Authors: He Wen-Zhuo , Wang Lei , Yin Chen-Xi , Yi Jia-Hong , Jin Ya-Nan , Jiang Chang , Guo Gui-Fang , Xia Liang-Ping 
Published: May 2022

Abstract
Purpose
Although the use of regorafenib plus nivolumab demonstrates promising outcomes in patients with refractory microsatellite stable (MSS) metastatic colorectal cancer (mCRC), other studies failed to observe such an effect. In addition, a comparison between regorafenib combined with programmed cell death protein 1 (PD-1) antibodies and regorafenib monotherapy has rarely been reported. The aim of this study was to assess whether regorafenib combined with a PD-1 antibody is superior to regorafenib monotherapy as third-line treatment for MSS mCRC.
Methods
Patients with MSS mCRC who received regorafenib combined with a PD-1 antibody or regorafenib monotherapy as third-line treatment were eligible for inclusion.
Results
In total, 179 patients were enrolled, of which 95 administered regorafenib combined with a PD-1 antibody and 84 administered regorafenib monotherapy. Overall, patients who administered regorafenib combined with a PD-1 antibody had similar progression-free survival (PFS) outcomes as those on regorafenib monotherapy (median PFS was 2.4 months and 1.9 months, respectively, P = 0.086). The administration of regorafenib combined with a PD-1 antibody showed significantly longer PFS than regorafenib monotherapy in both male (5.2 months vs. 2.4 months, P = 0.001) and female (3.9 months vs. 1.8 months, P = 0.037) patients without liver metastasis. Unexpectedly, female patients with liver metastasis who administered regorafenib combined with a PD-1 antibody showed inferior PFS outcomes than those who administered regorafenib monotherapy (1.8 months vs. 2.0 months, P = 0.030).
Conclusion
Liver metastasis and gender were predictors of survival benefit following the addition of a PD-1 antibody to regorafenib in patients with MSS mCRC.
A Hybrid Deep Learning Methodology for Breast Cancer Diagnosis using Magnetic Resonance Images
Authors: Mirbagheri Seyyedreza , Momeni Maryam 
Published: May 2022

Abstract
Today, breast cancer is one of the most common causes of cancer in women. Precise diagnosis of cancerous tissues based on images is essential in disease treatment before the disease progression. Although there are several image techniques for diagnosing, magnetic resonance (MR) imaging contains extensive clinical information which usable with other image modalities such as mammography and ultrasound. In this study, the hybrid of an autoencoder network with ResNet architecture was proposed to significantly improve classification accuracy to diagnose breast cancer lesions into two categories: benign and malignant in MR images. Using the MR breast cancer images of the QIN-Breast database, the results present the employment of an autoencoder as a preprocessor can enhance the efficiency of CNN and ultimately lead to an accurate diagnosis of benign and malignant tissues by 97.65%. The proposed method significantly improved the classification from the point of view of speed, accuracy, and precision. This cancerous tissue classification was employed only using MR images without manual segmentation and feature extraction.
Factors Associated with the Adult Children’s Willingness to Utilize Elderly Medical Escort Service for Outpatient Visit In China: A Mixed-methods Research
Authors: Zhou Huanhuan , Wang Yuhan , Hu Xianyu , Luo Shangqun , Lu Jue , Yan Min , Zhang Linlin , Li Xiaona 
Published: May 2022

Abstract
Background: China is facing big pressure due to its high aging rate. Compared to other age groups, the elderly are characterized by a high number of multiple chronic diseases and need to frequently visit hospitals. However, most seniors are unable to independently complete medical treatments in smart hospitals with complex self-help integrated machines, scattered departments, popular appointment registration, and convenient mobile payment, and need to be accompanied by their adult children. Medical escorts might replace the offspring’s role, but their willingness to utilize elderly medical escort service (EMES) is associated with different factors.Methods: This sequential mixed-methods research was performed in communities across three cities in Jiangsu Province, China. It included a cross-sectional survey with a convenient sample size of 1936 participants having medical experiences with the elderly, and face-to-face interviews with 21 individuals. The quantitative survey was used to determine the participants’ expectations and acceptability of EMES. The semi-structured interview was performed to explore the barriers and facilitators of utilizing EMES.Results: Among 1936 individuals that responded to the questionnaire, 68.2% were willing to use the EMES. The willingness to utilize EMES was associated with long-distance separation from seniors [OR=0.79, 95% CI (0.63-0.98), p=0.033], difficulties in taking leaves to accompany the elderly to medical appointments [OR=1.39, 95% CI (1.11-1.73), p=0.003], outpatient satisfaction [OR=1.24, 95% CI (1.13-1.36), p＜0.001], payment for EMES [OR=2.56, 95% CI (2.07-3.18), p＜0.001], escorts being trained [OR=2.35, 95% CI (1.80-3.07), p＜0.001] and licensed [OR=1.31, 95%CI (1.01-1.72), p=0.044], and EMES being graded [OR=1.93, 95% CI (1.48-2.51), p＜0.001]. Both data suggested that regarding training, participants paid more attention to professional ethics. Additionally, the traditional Chinese culture of filial piety can not be ignored while using EMES.Conclusions: This survey indicated that the demands of the children’s willingness to utilize EMES are high and urgent. The results might guide EMES providers to improve their professional skills especially ethics and combine the need for children to do their filial duty that would be welcomed by users.
Transcriptional Factor KLF11 is a new prognostic biomarker and potential therapeutic target in human sporadic invasive breast cancer
Authors: Lin Lili , Pfender Kristina , Ditsch Nina , Kuhn Christina , Rahmeh Martina , Peng Lin , Schmoeckel Elisa , Mayr Doris , Trillsch Fabian , Mahner Sven , Kessler Mirjana , Jeschke Udo , Hester Anna 
Published: May 2022

Abstract
BackgroundBreast cancer (BC) is a heterogeneous disease characterized by distinct molecular subtypes. Krüppel like Factor (KLF) family members in BC have been widely studied. However, the roles of KLFs as tumor-promoters or tumor-suppressors are context-dependent. KLF11, as a member of this family, the expression pattern and prognostic relevance of which in BC remains unclear.Methods To clarify whether KLF11 acts as a tumor-promoter or a tumor-suppressor in BC, we explored the prognostic role of the KLF11 in BC patients by performing immunohistochemistry (IHC) staining of KLF11 in 298 patients samples. Then we correlated the expression to clinicopathological characteristics and survival outcomes. To investigate the function of KLF11 in tumor cells, we performed different assays of cell viability, cell proliferation, and cell apoptosis assays in three distinct molecular subtypes of BC cell lines with siRNA-mediated loss-of-function of KLF11.ResultsIn the BC patient cohort, We demonstrated that KLF11 was higher in highly proliferative BC and lowest in luminal A-like BC. Furthermore, "KLF11-high" BC patients had shorter disease-free survival (DFS), distant-metastasis-free survival (DMFS), and local recurrence-free survival (LRFS). High KLF11 expression remained an independent indicator for DFS and DMFS of BC. The multivariate cox regression-dependent, KLF11-related nomograms of DFS and DMFS showed high accuracy in predicting BC patients' 3-,5- and 10 -year survival probability. Our results indicate that KLF11 might play a pro-tumor role in BC.From the KLF11-BC tumor cells perspective, the cellular functional assays confirmed that KLF11 acts as a pro-tumor transcription factor (TF) in BC cells via promoting proliferation and/or decreasing cell apoptosis. However, due to neoplastic intratumor heterogeneity, different cancer molecular subtypes could have different underlying mechanisms.ConclusionsPrior research has demonstrated that KLF11 expression is lower in BC compared to healthy breast tissue. However, we now could show that high KLF11 expression in BC is probably pro-tumorigenic and is associated with an impaired prognosis. Our study indicates that KLF11, as a transcriptional factor, acts as a new prognostic biomarker and might also be potentially a synergistic or an alternative therapeutic target for conventional targeting treatments of human BC.
Comprehensive immunohistochemical analysis of N6-methyladenosine (m6A) writers, erasers, and readers in endometrial cancer
Authors: Ralser Damian , Condic Mateja , Klümper Niklas , Ellinger Jörg , Staerk Christian , Egger Eva , Kristiansen Glen , Mustea Alexander , Thiesler Thore 
Published: May 2022

Abstract
Purpose: N6-methyladenosine (m6A) is the most frequent type of messenger RNA (mRNA) modification and is implicated in diverse physiological processes. The procedure of m6A RNA modification is regulated by a dynamic interaction of ‚writers’ (METTL3, METTL4, METTL14, WTAP, KIAA1429), ‚erasers’ (FTO, ALKBH5), and ‚readers’ (HNRNPA2B1, HNRNPC, YTHDC1, YTHDC1, YTHDF1-3). In the oncological context, alterations in m6A were identified to be critically involved in tumorigenesis, proliferation, angiogenesis, and drug resistance across diverse cancer entities including endometrial cancer (EC). Methods: In this study, we comprehensively examined the protein expression of m6A writers, readers and erasers by immunohistochemical staining in a cohort of N=65 EC patients. Protein expression data were analyzed with regard to clinical outcomes. Results: We identified enhanced protein expression levels of METTL3, METTL14, FTO, HNRNPA2B1, and HNRNPC, respectively to be of prognostic value and linked to a shortened overall survival in EC. Conclusion: Overall, our study points towards dysregulated m6A modification in EC and its possibility to serve as a promising prognostic biomarker.
B. adolescentis Orchestrates CD143 + CAFs to Suppress Colorectal Tumorigenesis by Wnt signalling-regulated GAS1
Authors: Chen Shujie , Fan Lina , Lin Yifeng , Qi Yadong , Xu Chaochao , Ge Qiwei , Zhang Ying , Wang Qiwen , Jia Dingjiacheng , Si Jianmin , Wang Liangjing 
Published: May 2022

Abstract
Background
The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B. adolescentis (B.a) and its possible mechanism on the manipulation of cancer-associated fibroblasts (CAFs) in CRC.
Methods
The relative abundance of B.a in the patients with CRC or the healthy individuals was analyzed. The role of B.a was evaluated in the CRC animal models. The single cell-RNA sequencing (scRNA-seq) was used to investigate the cell subsets in the TME. The expression level of Wnt signaling and its downstream GAS1 in CAFs were explored by western blot and qRT-PCR. Overexpression of GAS1 in NIH/3T3 was performed to investigate its effect on the subcutaneous tumor formation. Multi-immunofluorescence assay examined the expression level of CD143 and GAS1 on the tissue array.
Results
We found that B. a abundance was significantly reduced in CRC patients from two independent cohorts and the bacteria database of GMrepo. Supplementation with B. a suppressed ApcMin/+ spontaneous or AOM/DSS-induced tumorigenesis in mice. scRNA-seq revealed that B. a facilitated a new subset CD143+CAFs to highly express GAS1 and GAS1+CAFs existed a suppressive effect. Mechanistically, GAS1 were activated by the Wnt/β-catenin signaling in CD143+CAFs. B. a abundance was correlated with the expression level of CD143 and GAS1. The level of CD143+CAFs predicted the more satisfied survival in CRC patients.
Conclusions
These results highlight that B. a induced a new subset CD143+CAFs and provides a novel therapeutic target for probiotic-based modulation of TME in CRC.
Low contrast CTA before transcatheter aortic valve replacement: a systematic review and meta-analysis
Authors: Lacy Spencer C. , Benjamin Mina M. , Osman Mohammed , Syed Mushabbar A. , Kinno Menhel 
Published: May 2022

Abstract
Purpose: The use of low contrast CTA for TAVR is desirable in patients with renal dysfunction but is not yet well established. This systematic review and meta-analysis compares low contrast computed tomography angiography (CTA) versus conventional CTA in patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) planning.Methods: We performed a systematic literature review to identify clinical studies comparing imaging strategies for patients with aortic stenosis undergoing TAVR planning. The primary outcomes of image quality as assessed by the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were reported as random effects mean difference with 95% confidence interval. No prior ethical approval was required since all data is public. Results: Our search yielded 126 potential studies. We included 6 studies reporting on 353 patients. There was no difference in SNR between the low-dose and conventional protocols with a mean difference of -1.42 (95% CI -5.71-2.88, p = 0.52). There was no difference in CNR between the low-dose and conventional protocols with a mean difference of -3.83 (95% CI -9.98-2.32, p = 0.22).Conclusion: This systematic review and meta-analysis suggests that low contrast CTA for TAVR planning provides similar image quality to conventional CTA.
Equity-Efficiency Coordination Index of the Medical and Health Service System in China: 1991–2020
Authors: ZHAO Na , CHEN Kai 
Published: May 2022

Abstract
Background: This study measured the equity-efficiency of China’s Medical and Health Service System (MHS) from 1991 to 2020 – a period of medical and health system reform in China.Methods: Data were obtained from the China Statistical Yearbook 1992–2021. We developed a calculation method for the equity-efficiency coordination index to guide our exploration of the equity and efficiency of China’s MHS. This generated a broad, but nuanced understanding of the relationship between equity and efficiency. The equity of the MHS was calculated as the ratios between urban and rural residents’ individual cash health service expenditure as part of their disposable incomes, respectively. The efficiency of the MHS was estimated by means of the DEA-Malmquist model. We then established a Cartesian coordinate system, with equity as the horizontal axis and efficiency as the vertical axis. The optimal coordinated development state was located on the straight line without deviation, that is composed of points where equity and efficiency are equal. Finally, we constructed the equity-efficiency coordination index model according to the deviation between the actual position and the ideal position.Results: The equity of China’s MHS has significantly improved from 1998 to 2007, and the medical expenditure burden of rural residents was reduced compared with those of urban residents. After 2008, the gap in the equity of the MHS slowly widened. From 1995 to 2007, the efficiency of the MHS fluctuated and developed at a low level. The implementation of the new medical reform promoted the efficiency of the MHS. Conclusions: With the realization of universal medical insurance, the efficiency has been stable at a high level. In short, since the reform the construction of China’s MHS has undergone a comprehensive system reconstruction and reintegration. From the beginning to the realization of universal medical insurance, the equity of the MHS has been substantially promoted and the efficiency of the system has been improved.
The potential impacts of climate change on agriculture and fisheries production in 72 tropical coastal communities
Authors: Cinner Joshua E. , Caldwell Iain , Thiault Lauric , Ben John , Blanchard Julia L. , Coll Marta , Diedrich Amy , Eddy Tyler D. , Everett Jason D. , Folberth Christian , Gascuel Didier , Guiet Jerome , Gurney Georgina G. , Heneghan Ryan F. , Jägermeyr Jonas , Jiddawi Narriman , Lahari Rachael , Kuange John , Liu Wenfeng , Maury Oliver , Müller Christoph , Novaglio Camilla , Palacios-Abrantes Juliano , Petrik Colleen M. , Rabearisoa Ando , Tittensor Derek P. , Wamukota Andrew , Pollnac Richard 
Published: May 2022

Abstract

Climate change is expected to profoundly affect key food production sectors, including fisheries and agriculture. However, the potential impacts of climate change on these sectors are rarely considered jointly, and when they are, it is often at a national scale, which can mask substantial variability in how communities will be affected. Here, we combine socioeconomic surveys and intersectoral multi-model simulation outputs to conduct a sub-national analysis of the potential impacts of climate change on fisheries and agriculture in 72 coastal communities across five Indo-Pacific countries. Our study reveals three key findings: First, we find that the overall potential losses to fisheries is higher than potential losses to agriculture, but there is substantial within-country variability. Second, while more than two-thirds of locations will bear a double burden of potential losses to both fisheries and agriculture simultaneously, mitigation could reduce the proportion of places facing a double burden. Third, lower socioeconomic status communities are more likely to experience potential impacts than higher socioeconomic status communities.
Ordinary differential equations defined by a trigonometric polynomial field: Behavior of the solutions
Authors: OUKIL Walid 
Published: May 2022

Abstract
See manuscript PDF file for complete Abstract:We consider the ordinary differential equations defined by a trigonometric polynomial field, we prove that any solution $x$ admits a "rotation vector" $\rho\in \mathbb{R}^n$. More precisely, the function $t\mapsto x(t)-\rho t$ is bounded on time and it is a "weak almost periodic" function of "slope" $\rho$.
Co-created Mobile Apps for Palliative Care Using Community-Partnered Participatory Research: Development and Usability Study
Authors: Al-Mondhiry Jafar , D'Ambruoso Sarah , Pietras Christopher , Strouse Thomas , Benzeevi Dikla , Arevian Armen C , Wells Kenneth B 
Published: May 2022

Background
Open design formats for mobile apps help clinicians and stakeholders bring their needs to direct, co-creative solutions. Palliative care for patients with advanced cancers requires intensive monitoring and support and remains an area in high need for innovation.

Objective
This study aims to use community-partnered participatory research to co-design and pretest a mobile app that focuses on palliative care priorities of clinicians and patients with advanced cancer.

Methods
In-person and teleconference workshops were held with patient and family stakeholders, researchers, and clinicians in palliative care and oncology. Question prompts, written feedback, semistructured interviews, and facilitated group discussions identified the core palliative care needs. Using Chorus, a no-code app-building platform, a mobile app was co-designed with the stakeholders. A pretest with 11 patients was conducted, with semistructured interviews of clinician and patient users for feedback.

Results
Key themes identified from the focus groups included needs for patient advocacy and encouragement, access to vetted information, patient-clinician communication support, and symptom management. The initial prototype, My Wellness App, contained a weekly wellness journal to track patient-reported symptoms, goals, and medication use; information on self-management of symptoms; community resources; and patient and caregiver testimonial videos. Initial pretesting identified value in app-based communication for clinicians, patients, and caregivers, with suggestions for improving user interface, feedback and presentation of symptom reports, and gamification and staff coordinators to support patient app engagement.

Conclusions
The development of a mobile app using community-partnered participatory research is a low-technology and feasible intervention for palliative care. Iterative redesign and user interface expertise may improve implementation.
Phân tích tin cậy đối với chuỗi dữ liệu mô phỏng có tính lặp và tính chu kỳ
Authors: Trần Văn Lý , Bùi Phong Quy , Nguyễn Lê Phúc Anh , Trang Thị Hiền , Phan Thị Mỹ Tiên 
Published: May 2022

Kiểm định về sự phù hợp với các xác suất chuyển và kiểm định về tính độc lập của chuỗi dữ liệu mô phỏng là hai dạng phân tích tin cậy được đề cập trong bài báo. Các kiểm định này được áp dụng đối với chuỗi dữ liệu mô phỏng có tính lặp và tính chu kỳ. Chuỗi dữ liệu mô phỏng được giả thiết là chuỗi Markov bậc nhất có các xác suất chuyển ổn định. Dựa vào một số kết quả nghiên cứu đã có về những suy luận thống kê trên các chuỗi Markov, hai dạng thống kê – bình phương được xây dựng để sử dụng trong hai kiểm định đã nêu. Áp dụng minh họa được thực hiện trên chuỗi dữ liệu mô phỏng của dãy chỉ số sáng hàng ngày được khởi tạo từ mô hình Markov ẩn với bốn trạng thái.