bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction and verification of the key ingredients and molecular targets of Guizhi Fuling capsule against tumour metastasis and resistance
Authors: Han Li , Lv Qin , Guo Xiaojuan , Guo Kelei , Du Ruijuan , Li Fubo , Zhao Xulin , Bian Hua 
Published: October 2022

Abstract
Purpose
The well-known traditional Chinese formula Guizhi Fuling capsule (GFC) has been reported to reverse ovarian cancer drug resistance. Extrachromosomal DNA (ecDNA) plays an important role in tumour metastasis and resistance. The purpose of this study was to investigate the potential mechanisms by which GFC blocks tumour metastasis and reverses drug resistance by targeting ecDNA.

Methods
CNKI and PubMed were used to obtain pharmacokinetic research data on GFC in rats, and the bioactive ingredients detected in rat serum or plasma were collected. Network databases were used to screen the abnormally expressed genes in ecDNA, tumour metastasis genes, resistance genes, and the active ingredient targets of GFC. The KOBAS3.0 database was used to enrich the KEGG pathways and GO functions; the STRING platform was used to construct the core protein interaction network; and the molecular docking online tool SwissDock was used to analyse the binding activity of the core targets and the active ingredients. RT-qPCR, Western blotting and laser confocal microscopy were used to verify the effect of the sera containing GFC on ecDNA, mRNA and protein expression of key targets.

Results
Twenty-three bioactive ingredients of GFC were retrieved from PubMed and CNKI. Nine shared targets were simultaneously involved in abnormal genes in ecDNA, tumour metastasis and resistance and the active ingredient targets of GFC. GO functional analysis indicated that the cotargets involved cell proliferation, apoptotic regulation, nuclear functions, etc. The potential pathways involved in the reversal of tumour metastasis and drug resistance of GFC were the PI3K-Akt signalling, cancer, and platinum drug resistance pathways. Three shared proteins targeting ecDNA (AKT1, EGFR and MYC) stand out from the top 20 PPI targets, and all of the bioactive ingredients of GFC have strong binding affinity to the three proteins. The active ingredients can reduce the expression of MYC, EGFR and AKT1 mRNA and protein and the amount of ecDNA in drug-resistant OC cells.

Conclusions
GFC targeting ecDNA to reverse tumour metastasis and drug resistance has the characteristics of multiple ingredients, multiple targets, and multiple pathways, which provides a new perspective for the development of new drugs targeting ecDNA to benefit tumour treatment.
New Testament Theology and the Greek Language
Authors: Porter Stanley E. 
Published: October 2022

In this book, Stanley E. Porter offers a unique, language-based critique of New Testament theology by comparing it to the development of language study from the Enlightenment to the present. Tracing the histories of two disciplines that are rarely considered together, Porter shows how the study of New Testament theology has followed outmoded conceptual models from previous eras of intellectual discussion. He reconceptualizes the study of New Testament theology via methods that are based upon the categories of modern linguistics, and demonstrates how they have already been applied to New Testament Greek studies. Porter also develops a workable linguistic model that can be applied to other areas of New Testament research. Opening New Testament Greek linguistics to a wider audience, his volume offers numerous examples of the productivity of this linguistic model, especially in his chapter devoted to the case study of the Son of Man.
Outpatient treatment and clinical outcomes of bacteriuria in veterans: A retrospective cohort analysis
Authors: Rovelsky Suzette A. , Vu Michelle , Barrett Alexis K. , Bukowski Kenneth , Wei Xiangming , Burk Muriel , Jones Makoto , Echevarria Kelly , Suda Katie J , Cunningham Francesca , Madaras-Kelly Karl J ,   for the UTI Management Improvement Group
Published: October 2022

Abstract

Objective:
To conduct a contemporary detailed assessment of outpatient antibiotic prescribing and outcomes for positive urine cultures in a mixed-sex cohort.

Design:
Multicenter retrospective cohort review.

Setting:
The study was conducted using data from 31 Veterans’ Affairs medical centers.

Patients:
Outpatient adults with positive urine cultures.

Methods:
From 2016 to 2019, data were extracted through a nationwide database and manual chart review. Positive urine cultures were reviewed at the chart, clinician, and aggregate levels. Cases were classified as cystitis, pyelonephritis, or asymptomatic bacteriuria (ASB) based upon documented signs and symptoms. Preferred therapy definitions were applied for subdiagnoses: ASB (no antibiotics), cystitis (trimethoprim-sulfamethoxazole, nitrofurantoin, β-lactams), and pyelonephritis (trimethoprim-sulfamethoxazole, fluoroquinolone). Outcomes included 30-day clinical failure or hospitalization. Odds ratios for outcomes between treatments were estimated using logistic regression.

Results:
Of 3,255 cases reviewed, ASB was identified in 1,628 cases (50%), cystitis was identified in 1,156 cases (36%), and pyelonephritis was identified in 471 cases (15%). Of all 2,831 cases, 1,298 (46%) received preferred therapy selection and duration for cases where it could be defined. The most common antibiotic class prescribed was a fluoroquinolone (34%). Patients prescribed preferred therapy had lower odds of clinical failure: preferred (8%) versus nonpreferred (10%) (unadjusted OR, 0.74; 95% confidence interval [CI], 0.58–0.95; P = .018). They also had lower odds of 30-day hospitalization: preferred therapy (3%) versus nonpreferred therapy (5%) (unadjusted OR, 0.55; 95% CI, 0.37–0.81; P = .002). Odds of clinical treatment failure or hospitalization was higher for β-lactams relative to ciprofloxacin (unadjusted OR, 1.89; 95% CI, 1.23–2.90; P = .002).

Conclusions:
Clinicians prescribed preferred therapy 46% of the time. Those prescribed preferred therapy had lower odds of clinical failure and of being hospitalized.
Maleficent Comrades: War in Ukraine and COVID-19
Authors: Vuorio Alpo , Sajantila Antti , Kovanen Petri T. , Budowle Bruce 
Published: October 2022

Abstract
Infectious diseases and war are maleficent comrades. This reality applies equally well to the war in Ukraine and the current coronavirus disease 2019 (COVID-19) pandemic. Europe is facing a huge refugee crisis and potentially the conflict could worsen the COVID-19 pandemic. Initially, 2 major countries of concern are Poland, which has taken the majority of refugees, and Moldova, which has taken a very large number of refugees on a per capita basis. However, the concern extends to the rest of Europe because of the mobility of refugees beyond the first country they enter. Vaccinating, infection control, and boosting refugees should be a priority. However, complete prevention of COVID-19 is very complex because of other issues related to the success of prevention.
Large deviations of Poisson Telecom processes
Authors: Lifshits Mikhail , Nikitin Sergei 
Published: October 2022

AbstractWe study large-deviation probabilities of Telecom processes appearing as limits in a critical regime of the infinite-source Poisson model elaborated by I. Kaj and M. Taqqu. We examine three different regimes of large deviations (LD) depending on the deviation level. A Telecom process$(Y_t)_{t \ge 0}$scales as$t^{1/\gamma}$, wheretdenotes time and$\gamma\in(1,2)$is the key parameter ofY. We must distinguish moderate LD${\mathbb P}(Y_t\ge y_t)$with$t^{1/\gamma} \ll y_t \ll t$, intermediate LD with$ y_t \approx t$, and ultralarge LD with$ y_t \gg t$. The results we obtain essentially depend on another parameter ofY, namely the resource distribution. We solve completely the cases of moderate and intermediate LD (the latter being the most technical one), whereas the ultralarge deviation asymptotics is found for the case of regularly varying distribution tails. In all the cases considered, the large-deviation level is essentially reached by the minimal necessary number of ‘service processes’.
CANTORIAN MODELS OF PREDICATIVE
Authors: ROUVELAS PANAGIOTIS 
Published: October 2022

AbstractTangled Type Theory was introduced by Randall Holmes in [3] as a new way of approaching the consistency problem for
$\mathrm {NF}$
. Although the task of finding models for this theory is far from trivial (considering it is equiconsistent with
$\mathrm {NF}$
), ways of constructing models for certain fragments of it have been discovered. In this article, we present a simpler way of constructing models of predicative Tangled Type Theory and consequently of predicative
$\mathrm {NF}$
. In these new models of predicative
$\mathrm {NF}$
, the universe is well-orderable and equinumerous to the set of singletons.
Towards design of drugs and delivery systems with the Martini coarse-grained model
Authors: Kjølbye Lisbeth R. , Pereira Gilberto P. , Bartocci Alessio , Pannuzzo Martina , Albani Simone , Marchetto Alessandro , Jiménez-García Brian , Martin Juliette , Rossetti Giulia , Cecchini Marco , Wu Sangwook , Monticelli Luca , Souza Paulo C. T. 
Published: October 2022

Abstract
Coarse-grained (CG) modelling with the Martini force field has come of age. By combining a variety of bead types and sizes with a new mapping approach, the newest version of the model is able to accurately simulate large biomolecular complexes at millisecond timescales. In this perspective, we discuss possible applications of the Martini 3 model in drug discovery and development pipelines and highlight areas for future development. Owing to its high simulation efficiency and extended chemical space, Martini 3 has great potential in the area of drug design and delivery. However, several aspects of the model should be improved before Martini 3 CG simulations can be routinely employed in academic and industrial settings. These include the development of automatic parameterisation protocols for a variety of molecule types, the improvement of backmapping procedures, the description of protein flexibility and the development of methodologies enabling efficient sampling. We illustrate our view with examples on key areas where Martini could give important contributions such as drugs targeting membrane proteins, cryptic pockets and protein–protein interactions and the development of soft drug delivery systems.
Vitamin D supplementation and immune-related markers: an update from nutrigenetic and nutrigenomic studies
Authors: Antony Dhanapal Anto Cordelia Tanislaus , Vimaleswaran Karani Santhanakrishnan 
Published: October 2022

AbstractVitamin D is both a nutrient and a neurologic hormone that plays a critical role in modulating immune responses. While low levels of vitamin D are associated with increased susceptibility to infections and immune-related disorders, vitamin D supplementation has demonstrated immunomodulatory effects that can be protective against various diseases and infections. Vitamin D receptor is expressed in immune cells that have the ability to synthesise the active vitamin D metabolite. Thus, vitamin D acts in an autocrine manner in a local immunologic milieu in fighting against infections. Nutrigenetics and nutrigenomics are the new disciplines of nutritional science that explore the interaction between nutrients and genes using distinct approaches to decipher the mechanisms by which nutrients can influence disease development. Though molecular and observational studies have proved the immunomodulatory effects of vitamin D, only very few studies have documented the molecular insights of vitamin D supplementation. Until recently, researchers have investigated only a few selected genes involved in the vitamin D metabolic pathway that may influence the response to vitamin D supplementation and possibly disease risk. This review summarises the impact of vitamin D supplementation on immune markers from nutrigenetics and nutrigenomics perspective based on evidence collected through a structured search using PubMed, EMBASE, Science Direct and Web of Science. The research gaps and shortcomings from the existing data and future research direction of vitamin D supplementation on various immune-related disorders are discussed.
Public Gender Egalitarianism: A Dataset of Dynamic Comparative Public Opinion toward Egalitarian Gender Roles in the Public Sphere
Authors: Woo Byung-Deuk , Goldberg Lindsey A. , Solt Frederick 
Published: October 2022

AbstractSocietal attitudes toward gender roles in the workplace and politics play a central part in theorizing on the difficulty women face in achieving political equality, but shortcomings in the available data have prevented direct examination of many implications of these theories. Drawing on recent advances in latent-variable modeling of public opinion and a comprehensive collection of survey data, we present the Public Gender Egalitarianism dataset to address this need: comparable estimates of the public's attitudes on gender equality in the public sphere across more than one hundred countries over time. These Public Gender Egalitarianism scores are strongly correlated with responses to individual survey items and with women's rates of participation in the labor force and corporate boards. We expect that the Public Gender Egalitarianism data will become an invaluable source for broadly cross-national and longitudinal research on the causes and consequences of collective attitudes toward gender equality in politics and the economy.
Fractional powers of higher-order vector operators on bounded and unbounded domains
Authors: Baracco Luca , Colombo Fabrizio , Peloso Marco M. , Pinton Stefano 
Published: October 2022

AbstractUsing the $H^{\infty }$-functional calculus for quaternionic operators, we show how to generate the fractional powers of some densely defined differential quaternionic operators of order $m\geq 1$, acting on the right linear quaternionic Hilbert space $L^{2}(\Omega,\mathbb {C}\otimes \mathbb {H})$. The operators that we consider are of the type
\begin{align*} T=i^{m-1}\left(a_1(x) e_1\partial_{x_1}^{m}+a_2(x) e_2\partial_{x_2}^{m}+a_3(x) e_3\partial_{x_3}^{m}\right), \quad x=(x_1,\, x_2,\, x_3)\in \overline{\Omega}, \end{align*}where $\overline {\Omega }$ is the closure of either a bounded domain $\Omega$ with $C^{1}$ boundary, or an unbounded domain $\Omega$ in $\mathbb {R}^{3}$ with a sufficiently regular boundary, which satisfy the so-called property $(R)$ (see Definition 1.3), $e_1,\, e_2,\, e_3\in \mathbb {H}$ which are pairwise anticommuting imaginary units, $a_1,\,a_2,\, a_3: \overline {\Omega } \subset \mathbb {R}^{3}\to \mathbb {R}$ are the coefficients of $T$. In particular, it will be given sufficient conditions on the coefficients of $T$ in order to generate the fractional powers of $T$, denoted by $P_{\alpha }(T)$ for $\alpha \in (0,1)$, when the components of $T$, i.e. the operators $T_l:=a_l\partial _{x_l}^{m}$, do not commute among themselves. This kind of result is to be understood in the more general setting of the fractional diffusion problems. The method used to construct the fractional power of a quaternionic linear operator is a generalization of the method developed by Balakrishnan.
State Controlling Shareholders and Payout Policy
Authors: Lin Chen , Liu Hang , Ni Chenkai , Zhang Bohui 
Published: October 2022

AbstractWe study the role of state controlling shareholders in corporate payout policy. The State Capital Operation Program in China requiresparentcentral state-owned enterprises (CSOEs) to contribute part of their consolidated income to a new fiscal fund. We find thatlistedCSOEs, partially controlled byparentCSOEs, experience significant reductions in dividend payouts as the income-contribution ratio increases. The dividend reductions are concurrent with increases in intragroup resource transfers—listedCSOEs’ loans to, and commercial trades with, group peers. The program yields adverse consequences forlistedCSOEs’ investment and employment, yet being mitigated by group-level dividend reductions.
Neuromuscular organization and haptoral armament of Polyclithrum ponticum (Monogenea: Gyrodactylidae)
Authors: Petrov A. A. , Dmitrieva E. V. , Plaksina M. P. 
Published: October 2022

Abstract
Most gyrodactylids have a haptor armed with a pair of hamuli, two connecting bars and 16 marginal hooks. In some gyrodactylids, however, the haptor is disc-shaped and reinforced by additional sclerites. The genus Polyclithrum has arguably the most elaborate haptor in this group. This study aimed to gain better understanding of the anatomy of Polyclithrum by examining neuromusculature and haptoral armament of Polyclithrum ponticum, a species parasitizing Mugil cephalus in the Black Sea, with emphasis on haptoral sclerites and musculature in connection with host-attachment mechanisms. Musculature was stained by phalloidin, the nervous system by anti-serotonin and anti-FMRFamide antibodies, and haptoral sclerites were visualized in reflected light. The study provided new information on sclerites: in addition to previously described supplementary sclerites (A1–6), ear-shaped sclerites (ESSs) and two paired groups of ribs, reflected light revealed a rod-shaped process on the ESSs and a pair of small posterior sclerites. The sclerites were shown to be operated by 16 muscles, the most prominent of which were two transverse muscles connecting the hamular roots, three muscles attached to sclerite A2, the muscle fibres of anterior ribs and a set of extrinsic muscles. The nervous system consists of a pair of cerebral ganglia connected by a commissure and three pairs of nerve cords that unite in the haptor to form a loop between the opposite cords. The arrangement of sclerites and muscles suggests that Polyclithrum initiates the attachment by clamping a host's surface with longitudinally folded haptor and then secures its position with marginal hooks.
The Influence of Raul Prebisch on Economic Policy-Making in Argentina, 1950–1962
Authors: Sikkink Kathryn 
Published: October 2022

Se me elogió y se me criticó duramente por haber preconizado la industrialización para América Latina, menos en mi país. El país vivía en las nubes. En estos años no se había estudiado las ideas de CEPAL en Argentina. [¿Por qué?] Yo no estuve aquí en el país, así no sé, pero tal vez por oposición a mí. Tal vez.Raúl PrebischInterview, 23 October 1985In much of Latin America during the 1950s, Raúl Prebisch, then Executive Secretary of the Comisión Económica para América Latina (CEPAL, known in English as the Economic Commission for Latin America, or ECLA), was recognized as a progressive and innovative development theorist and policy activist. In certain government circles in the United States, meanwhile, he was viewed with suspicion as a leftist critic of standard economic wisdom. Yet in his home country of Argentina during the same period, Prebisch was commonly identified with both conservative groups and liberal economic thought.
Assessing the core microbial symbionts of jellyfish in Indonesian and Vietnamese marine lakes
Authors: Ferreira Marina R.S. , Cleary Daniel F.R. , Bat Nguyen K. , Polónia Ana R.M. , Gomes Newton C.M. 
Published: October 2022

AbstractJellyfish are a well-known component of marine ecosystems. Here, we aimed to assess whether populations of the jellyfish speciesMastigiascf.papuaandCassiopea ornatainhabiting different marine lakes and jellyfish species from open water habitat host ‘core’ symbionts and if there is evidence of species-specific host-microbial associations. Compositionally, jellyfishes hosted prokaryotic communities distinct from those found in water samples. All jellyfish samples across habitats and species exhibited a core OTU, assigned to the genusEndozoicomonas. This OTU was particularly abundant (>90% of all sequences) inC. ornatafrom one Papuan marine lake. Additionally, an OTU assigned to the Entomoplasmatales order was found in all but two jellyfish specimens, and was particularly abundant in marine lake specimens from Berau and Papua, Indonesia. Given the well-known relationship betweenEndozoicomonasandSymbiodiniumspp., we tested forSymbiodiniumpresence in pooled specimens ofM. papuafrom Berau. Our results showed that OTUs assigned to the genusSymbiodiniumaccounted for >99% of all sequences in jellyfish-associated microeukaryotic communities; these were closely related to organisms fromSymbiodiniumclade C. These results suggest the existence of a widespread and abundant jellyfish core symbiont, which may interact with symbioticSymbiodiniumpopulations to influence host fitness.
Fish parasites (special issue)
Authors: Sayyaf Dezfuli Bahram , Scholz Tomáš 
Published: October 2022

AbstractFish (Elasmobranchia and Actinopterygii) inhabit the majority of aquatic habitats globally. They are crucial for human nutrition but they may be negatively affected by parasitic protists and metazoan parasites. Fish parasites are also an extraordinary group of animals because of their ecological and evolutionary importance and unique adaptations to parasitism. They also play a key role in ecosystem functioning. In the present special issue, 13 review and research articles on major groups of fish parasites are provided to document the current advancement in our understanding of different aspects of their biology, ecology and associations with their fish hosts. The existing gaps in our knowledge of these peculiar animals are mapped and future trends in their research outlined.
Welfare Attitudes in Crisis: The Role of Ideology in Healthcare Satisfaction in Portugal and Ireland
Authors: POPIC TAMARA , BURLACU DIANA 
Published: October 2022

AbstractPrevious studies have documented that crisis trends are associated with negative changes in healthcare satisfaction. Yet, most research has focused on the role of self-interest and little is known about the ideological dimension of these changes. The article investigates this underexplored topic by examining the ideological divide in satisfaction with healthcare in two countries strongly hit by the recent economic crisis, Portugal and Ireland. The results of the empirical analysis based on the European Social Survey data from 2008 to 2015 show that ideology played a role in shaping healthcare satisfaction in both countries. In Portugal, healthcare satisfaction declined more for the left- than for the right-oriented, while in Ireland the right-oriented demonstrated a stronger decline in satisfaction than the left-oriented. In addition, the results identify an interaction between ideology and self-interest, showing that ideology trumps self-interest among the low income, but the opposite is true among the high income groups. Overall, these findings suggest that there is a substantive ideology-driven dimension in public satisfaction with health systems and point to the need for theoretical integration of different approaches in the analysis of healthcare attitudes in the crisis context.