bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic analysis of mistletoe prescriptions in clinical studies
Authors: Staupe Henrike , Buentzel Judith , Keinki Christian , Buentzel Jens , Huebner Jutta 
Published: December 2022

AbstractPurposeMistletoe treatment is discussed controversial as a complementary treatment for cancer patients. Aim of this systematic analysis is to assess the concept of mistletoe treatment in the clinical studies with respect to indication, type of mistletoe preparation, treatment schedule, aim of treatment, and assessment of treatment results.MethodsIn the period from August to December 2020, the following databases were systematically searched: Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, CINAHL, and “Science Citation Index Expanded” (Web of Science). We assessed all studies for study types, methods, endpoints and mistletoe preparations including their ways of application, host trees and dosage schedules.ResultsThe search concerning mistletoe therapy revealed 3296 hits. Of these, 102 publications and at total of 19.441 patients were included. We included several study types investigating the application of mistletoe in different groups of participants (cancer patients of any type of cancer were included as well as studies conducted with healthy volunteers and pediatric patients). The most common types of cancer were breast cancer, pancreatic cancer, colorectal cancer and malignant melanoma. Randomized controlled studies, cohort studies and case reports make up most of the included studies. A huge variety was observed concerning type and composition of mistletoe extracts (differing pharmaceutical companies and host trees), ways of applications and dosage schedules. Administration varied e. g. between using mistletoe extract as sole treatment and as concomitant therapy to cancer treatment. As the analysis of all studies shows, there is no relationship between mistletoe preparation used, host tree and dosage, and cancer type.ConclusionsOur research was not able to deviate transparent rules or guidelines with respect to mistletoe treatment in cancer care.
Deep variational models for collaborative filtering-based recommender systems
Authors: Bobadilla Jesús , Ortega Fernando , Gutiérrez Abraham , González-Prieto Ángel 
Published: December 2022

AbstractDeep learning provides accurate collaborative filtering models to improve recommender system results. Deep matrix factorization and their related collaborative neural networks are the state of the art in the field; nevertheless, both models lack the necessary stochasticity to create the robust, continuous, and structured latent spaces that variational autoencoders exhibit. On the other hand, data augmentation through variational autoencoder does not provide accurate results in the collaborative filtering field due to the high sparsity of recommender systems. Our proposed models apply the variational concept to inject stochasticity in the latent space of the deep architecture, introducing the variational technique in the neural collaborative filtering field. This method does not depend on the particular model used to generate the latent representation. In this way, this approach can be applied as a plugin to any current and future specific models. The proposed models have been tested using four representative open datasets, three different quality measures, and state-of-the-art baselines. The results show the superiority of the proposed approach in scenarios where the variational enrichment exceeds the injected noise effect. Additionally, a framework is provided to enable the reproducibility of the conducted experiments.
„Mutig, bunt, aktiv leben mit Metastasen“
Authors: Mählmann S. , Kerek-Bodden H. , Weis J. 
Published: December 2022

Zusammenfassung
Hintergrund
Die Diagnose einer metastasierten Krebserkrankung ist für betroffene Frauen mit zahlreichen psychischen, körperlichen und sozialen Belastungen verbunden, die im Rahmen bestehender Selbsthilfeangebote häufig nicht ausreichend thematisiert werden können. Vor diesem Hintergrund hat die Frauenselbsthilfe Krebs e. V. ein innovatives Selbsthilfeangebot für Frauen mit einer metastasierten Krebserkrankung in Form von moderierten Onlineselbsthilfetreffen geschaffen.

Fragestellung
Die begleitende wissenschaftliche Evaluation fokussierte hierbei verschiedene Prozess- und Ergebnismerkmale dieses Angebots, um den Nutzen und mögliche Schwierigkeiten zu identifizieren.

Material und Methode
Im Rahmen der Begleitforschung wurden die Teilnehmerinnen (n = 97) mittels Onlinefragebögen zu dem Angebot befragt. Zu zwei Messzeitpunkten wurden die Erwartungen an das Angebot und Befürchtungen (T0 Baseline) sowie eingetretene Erfahrungen und Schwierigkeiten (T1 nach sechs Monaten) erhoben. Das Angebot wurde hinsichtlich des subjektiven Nutzens bewertet und Veränderungen des Gesundheitszustands (psychosoziale Belastung, Depressivität, Angstsymptomatik und gesundheitsbezogene Lebensqualität) bei den Teilnehmerinnen gemessen.

Ergebnisse
Die Ergebnisse zeigen, dass das Angebot die Erwartungen der betroffenen Frauen überwiegend erfüllte und als hilfreich bewertet wurde. Befürchtungen und Schwierigkeiten traten kaum auf. Zum Zeitpunkt T1 konnte eine signifikante Verringerung der psychosozialen Belastung (t (43) = 3,41, p = 0,001) gemessen werden.

Schlussfolgerung
Eine Verstetigung des Angebots könnte eine wichtige Ergänzung im Versorgungssystem zur Verringerung psychosozialer Belastungen von betroffenen Frauen bieten.
Routine postoperative admission to the neurocritical intensive care unit after microvascular decompression: necessary or can it be abandoned?
Authors: Hatipoglu Majernik Gökce , Wolff Fernandes Filipe , Al-Afif Shadi , Heissler Hans E. , Palmaers Thomas , Atallah Oday , Scheinichen Dirk , Krauss Joachim K. 
Published: December 2022

Abstract Postoperative neurocritical intensive care unit (NICU) admission of patients who underwent craniotomy for close observation is common practice. In this study, we performed a comparative analysis to determine if there is a real need for NICU admission after microvascular decompression (MVD) for cranial nerve disorders or whether it may be abandoned. The present study evaluates a consecutive series of 236 MVD surgeries performed for treatment of trigeminal neuralgia (213), hemifacial spasm (17), vagoglossopharyngeal neuralgia (2), paroxysmal vertigo (2), and pulsatile tinnitus (2). All patients were operated by the senior surgeon according to a standard protocol over a period of 12 years. Patients were admitted routinely to NICU during the first phase of the study (phase I), while in the second phase (phase II), only patients with specific indications would go to NICU. While 105 patients (44%) were admitted to NICU postoperatively (phase I), 131 patients (56%) returned to the ward after a short stay in a postanaesthesia care unit (PACU) (phase II). Specific indications for NICU admission in phase I were pneumothorax secondary to central venous catheter insertion (4 patients), AV block during surgery, low blood oxygen levels after extubation, and postoperative dysphagia and dysphonia (1 patient, respectively). There were no significant differences in the distribution of ASA scores or the presence of cardiac and pulmonary comorbidities like congestive heart failure, arterial hypertension, or chronic obstructive pulmonary disease between groups. There were no secondary referrals from PACU to NICU. Our study shows that routine admission of patients after eventless MVD to NICU does not provide additional value. NICU admission can be restricted to patients with specific indications. When MVD surgery is performed in experienced hands according to a standard anaesthesia protocol, clinical observation on a neurosurgical ward is sufficient to monitor the postoperative course. Such a policy results in substantial savings of costs and human resources.
Introduction: Symposium Limitarianism: Extreme Wealth as a Moral Problem
Authors: Timmer Dick , Neuhäuser Christian 
Published: December 2022

AbstractThe growing concentration of wealth has acquired a new urgency in recent years. One particular view in this context is developed by Ingrid Robeyns in her ground-breaking work on limitarianism. According to this view, no one should have more than a certain amount of valuable goods, such as income and wealth. The contributors to this symposium, Brian Berkey, David Axelsen and Lasse Nielsen, Jessica Flanigan and Christopher Freiman, and Lena Halldenius, critically examine various aspects of limitarianism. In particular, they examine how limitarianism should be interpreted and developed as a principle of justice, on what reasons speak in favour and against limitarianism, and on how limitarianism relates to other principles of distributive justice. Our hope is that this symposium will contribute to the ongoing debate in political philosophy about the concentration of wealth and economic justice.
Enhanced dispersion reduction using apodized uniform fiber Bragg grating for optical MTDM transmission systems
Authors: Mustafa Fathy M. , Kholidy Hisham A. , Sayed Ahmed F. , Aly Moustafa H. 
Published: December 2022

AbstractThe aim of this work is to propose a model for enhancing chromatic dispersion compensation in standard single mode optical fibers (SSMFs). The proposed model consists of a single stage Apodized Uniform Fiber Bragg Gratings (AUFBG) in a post-compensation scheme. It is based on the Maximum Time Division Multiplexing (MTDM) technique. The performance of the proposed model is evaluated through the quality factor (Q-factor) and Bit Error Rate (BER) in four cases, in a comparative study. In case one, the system performance is evaluated without using UFBG. The other cases study the effect of the proposed model with using different connections schemes and the most common apodization functions. For simulation, the proposed model is connected in a 10 Gbps WDM 70 km link under ordinary operating parameters. The simulation and evaluation process is conducted by Optisystem 7.0. In the pre-compensation scheme, the best results are obtained as a maximum Q-factor of 9.2 and a minimum BER of 3.25 × 10–20, using a tanh apodization function. The proposed model realizes an improvement over the related work by at least ~ 68%.
Real-Time Investigations and Simulation on the Impact of Lighting Ambience on Circadian Stimulus
Authors: Mathew Veena , Kurian Ciji Pearl , Varghese Susan G. , Priyadarshini Kannika , Bhandary Siddanth S. 
Published: December 2022

AbstractIndoor lighting, incorporated with visual and circadian needs, is the upcoming goal of lighting designers. In tropical and subtropical regions, where more daylight is available, daylight harvesting is a prime source of ambient lighting indoors. This paper aims to study various cases of lighting ambience to investigate the circadian lighting capability in terms of the circadian stimulus (CS) of the system under consideration. The instances considered are simulation studies in an open office plan and real-time experimentations in a test workbench and a faculty cabin. Daylight integration was undertaken through controlled venetian blinds, tunable sources and a commercially available human-centric lighting system. The result and analysis show the influence of spectrally tunable light sources on CS rather than fixed light sources. Due to the varying CCT of tunable LED luminaire, circadian stimulation for an occupant can be easily incorporated without crossing the limits of vertical and horizontal illuminance, which may lead to visual discomfort. The findings from this study reveal that daylight–artificial light integration scheme with controlled shading and spectrally tunable source provides the optimal solution for glare-free, energy-effective and circadian entrainment, i.e. human-centric lighting (HCL). With the help of simulations, pre-evaluation will aid the lighting engineers in making a better choice among the various lighting-controlled schemes to implement HCL in indoor office spaces.
Homogenized skew PBW extensions
Authors: Suárez Héctor , Reyes Armando , Suárez Yésica 
Published: December 2022

AbstractIn this paper, we provide a new and more general filtration to the family of noncommutative rings known as skew PBW extensions. We introduce the notion of $$\sigma $$
σ
-filtered skew PBW extension and study some homological properties of these algebras. We show that the homogenization of a $$\sigma $$
σ
-filtered skew PBW extension A over a ring R is a graded skew PBW extension over the homogenization of R. Using this fact, we prove that if the homogenization of R is Auslander-regular, then the homogenization of A is a domain Noetherian, Artin–Schelter regular, and A is Noetherian, Zariski and (ungraded) skew Calabi–Yau.
iHypoxia: An Integrative Database of Protein Expression Dynamics in Response to Hypoxia in Animals
Authors: Liu Ze-Xian , Wang Panqin , Zhang Qingfeng , Li Shihua , Zhang Yuxin , Guo Yutong , Jia Chongchong , Shao Tian , Li Lin , Cheng Han , Wang Zhenlong 
Published: December 2022

Abstract
Mammals have evolved mechanisms to sense hypoxia and induce hypoxic responses. Recently, high-throughput techniques have greatly promoted global studies of protein expression changes during hypoxia and the identification of candidate genes associated with hypoxia-adaptive evolution, which have contributed to the understanding of the complex regulatory networks of hypoxia. In this study, we developed an integrated resource for the expression dynamics of proteins in response to hypoxia (iHypoxia), and this database contains 2589 expression events of 1944 proteins identified by low-throughput experiments (LTEs) and 422,553 quantitative expression events of 33,559 proteins identified by high-throughput experiments from five mammals that exhibit a response to hypoxia. Various experimental details, such as the hypoxic experimental conditions, expression patterns, and sample types, were carefully collected and integrated. Furthermore, 8788 candidate genes from diverse species inhabiting low-oxygen environments were also integrated. In addition, we conducted an orthologous search and computationally identified 394,141 proteins that may respond to hypoxia among 48 animals. An enrichment analysis of human proteins identified from LTEs shows that these proteins are enriched in certain drug targets and cancer genes. Annotation of known posttranslational modification (PTM) sites in the proteins identified by LTEs reveals that these proteins undergo extensive PTMs, particularly phosphorylation, ubiquitination, and acetylation. iHypoxia provides a convenient and user-friendly method for users to obtain hypoxia-related information of interest. We anticipate that iHypoxia, which is freely accessible at https://ihypoxia.omicsbio.info, will advance the understanding of hypoxia and serve as a valuable data resource.
Antimicrobial prescription at the time of discharge from a tertiary-care hospital in India: A potential target for reducing use at the community level
Authors: Gupta Stuti , Gunjiyal Jacinta , Varma Sharin , Malhotra Rajesh , Shrivastav Sharad , Parveen Rasna , Mathur Purva 
Published: December 2022

Abstract
We evaluated the appropriateness of antibiotic prescriptions at discharge from a tertiary-care hospital in India. Of the 790 adult patients included, 84.4% received antibiotics. Microbiological specimens were taken from 67.3% of these patients, and pathogens were identified in 28.8% of cases. Overuse of antimicrobials at hospital discharge should be curtailed.
At the vanguard: Leaders’ perspectives on establishing healthcare system infection prevention programs
Authors: Stevens Michael P. , Wright Sharon B. , Kaye Keith S. , Zuckerman Jerry M. , Passaretti Catherine L. , Martinello Richard A. , Babcock Hilary M. , Edmond Michael B. , Snyder Graham M. 
Published: December 2022

Abstract
Hospitals are increasingly consolidating into health systems. Some systems have appointed healthcare epidemiologists to lead system-level infection prevention programs. Ideal program infrastructure and support resources have not been described. We informally surveyed 7 healthcare epidemiologists with recent experience building and leading system-level infection prevention programs. Key facilitators and barriers for program structure and implementation are described.
Right-wing extremism and lone-actor violence in Italy: the case of the 2018 Macerata shooting
Authors: Marone Francesco 
Published: December 2022

AbstractOn 3 February 2018, in the town of Macerata, an Italian citizen with far-right sympathies deliberately fired several shots from his car at nine African immigrants, injuring six. The article argues that this shooting can be considered an act of lone-actor terrorism, an anomaly in the Italian context. Based on the social science literature on this subject, the paper analyses the profile of the shooter and the dynamics of the attack. Moreover, adopting a relational perspective to radicalisation, it examines the attacker's interactions: on the one hand, he was in contact with different political organisations that could represent ‘echo chambers’ for the tacit validation or even the justification and amplification of radical beliefs, including on the relation between immigration and security; on the other hand, he was not subject to their discipline and social control. This peripheral social position helps explain this case of lone-actor terrorism, in a national context where far-right mobilisation and violence have historically assumed collective forms.
Comparative qualitative and quantitative analysis of lactic acid bacteria by molecular methods in different Greek cheeses
Authors: Tsirigoti Evanthia , Psomas Evdoxios , Ekateriniadou Loukia V. , Papadopoulos Athanasios I. , Boukouvala Evridiki 
Published: December 2022

AbstractIn the present research communication, we report on identification and quantification of four main lactic acid bacteria (LAB) genera (Lactococcus, Lactobacillus, Streptococcus and Leuconostoc), most common in Greek cheeses, by a novel culture-independent method. More specifically, new primers were designed to be used in both multiplex PCR for simultaneous identification and in real-time PCR for quantification of the LAB. The method was validated by applying it in parallel to culture-dependent method in a variety of cheeses from different Greek geographical locations, of different animal milk origins and of different production methods. While the standard plate culture method showed absence of Leuconostoc sp. in all cheeses, the culture-independent methods detected all four LAB genera studied. Furthermore, the relative presence of the four genera detected by the culture-independent method showed a pattern present in almost all cheese samples tested, indicating Lactococcus genus as the dominant one.
Identifying the Effects of Macroeconomic Attention Through Foreign Investor Distraction
Authors: Marmora Paul 
Published: December 2022

AbstractWhile the causal impact of limited attention to macroeconomic news is difficult to detect, this article proposes one solution: exploiting when foreign investors are “distracted” by risk factors in their home markets. I demonstrate that financial activity in the average foreign investor’s home market decreases foreign attention paid to 21 emerging economies, measured using Google search volume for economy-specific financial terms that emanate from outside each economy’s border. Exploiting this effect using an instrumental variables approach, I find that an exogenous increase in foreign attention preceding a scheduled monetary policy rate announcement raises preannouncement stock returns and announcement day turnover.
Larger insects in a colder environment? Elevational and seasonal intraspecific differences in tropical moth sizes on Mount Cameroon
Authors: Papandreou Fotoula , Hodeček Jiří , Maicher Vincent , Delabye Sylvain , Pyrcz Tomasz , Tropek Robert 
Published: December 2022

Abstract
Bergmann’s Rule describes an increase in the body size of endothermic animals with decreasing environmental temperatures. However, in ectothermic insects including moths, some of the few existing studies investigating size patterns along temperature gradients do not follow the Bergmann’s Cline. Intraspecific differences in moth sizes along spatiotemporal temperature gradients are unknown from the Palaeotropics, hindering general conclusions and understanding of the mechanism responsible. We measured intraspecific forewing size differences in 28 Afrotropical moth species sampled in 3 seasons along an elevational gradient on Mount Cameroon, West/Central Africa. Size increased significantly with elevation in 14 species but decreased significantly in 5 species. Additionally, we found significant inter-seasonal size differences in 21 species. Most of these variable species had longer forewings in the transition from the wet to dry season, which had caterpillars developing during the coldest part of the year. We conclude that environmental temperature affects the size of many Afrotropical moths, predominantly following prevailingly following Bergmann’s Cline. Nevertheless, the sizes of one-third of the species demonstrated a significant interaction between elevation and season. The responsible mechanisms can thus be assumed to be more complex than a simple response to ambient temperature.
Individual differences modulate sensitivity to implicit causality bias in both native and nonnative processing
Authors: Wang Tingting , Gabriele Alison 
Published: December 2022

AbstractThe question of whether L2 learners can use discourse cues online during pronoun resolution remains debated in the field. We examine one factor that has been argued to impact pronoun resolution in native speakers, implicit causality (IC) bias, a property related to certain verbs in which one of verb’s arguments are considered to be the cause of an action. We investigate whether individual differences modulate sensitivity to IC bias in both native English speakers and Chinese-speaking learners of English, examining whether variability is similarly explained in the two populations. Results from a sentence completion task and a self-paced reading (SPR) task show similar sensitivity to IC bias in both groups; reading times on the SPR task were also modulated by working memory and vocabulary knowledge. The findings suggest that L2 learners are successful in using discourse-level cues during processing and that variability is qualitatively similar in both learners and natives.
The Forger’s tale: an insider’s account of corrupting the corpus of Cycladic figures
Authors: Tsirogiannis Christos , Gill David W.J. , Chippindale Christopher 
Published: December 2022

AbstractMany of the known Cycladic figures – the late prehistoric human-shaped sculptures from the Aegean archipelago – came from twentieth-century illicit excavations, especially in the 1960s and 1970s. It is also known that figures were being faked at the time and perhaps also earlier: a few fakes have been identified, whilst other figures are under suspicion. Interviews with a man who faked Cycladic figures in the 1980s and 1990s give us a first insider’s autobiographical account of the forging business. This article offers, step-by-step, the method that two forgers developed to create fake figures, to treat them so that they appeared ancient, and to sell them on. The forger has identified a few of these forgeries from photographs of figures; his story is consistent with other information and seems to ring true. By verifying various elements in the forger’s testimony – from names of well-known figures in the modern antiquities market to small details and dates – we have been able to evaluate the validity of the narrative; to use it in order to uncover the true paths that fake objects followed into various collections; and to highlight valuable provenance information that no one involved in trading these objects was ever willing to provide.