bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel computerized cognitive test for the detection of MCI and its association with neurodegeneration in Alzheimer’s disease prone brain regions
Authors: Cid Rosie Curiel , Zheng D. Diane , Kitaigorodsky Marcela , Adjouadi Malek , Crocco Elizabeth A. , Georgiou Mike , Gonzalez-Jimenez Christian , Goryawala Mohammed , ORTEGA ALEXANDRA , Nagornaya Natalya , Pattany Pradip , Sfakianaki Efrosyni , Visser Ubbo , Loewenstein David A. 
Published: May 2022

Abstract
During the prodromal stage of Alzheimer’s disease (AD), neurodegenerative changes can be identified by measuring volumetric loss in AD-prone brain regions on MRI. Cognitive assessments sensitive enough to measure the early brain-behavior manifestations of AD and correlate with biomarkers of neurodegeneration are needed to identify and monitor individuals at risk for dementia. Weak sensitivity to early cognitive change has been one major limitation of traditionally used assessment tools. In this study, we focused on expanding our previous work by determining whether a digitized cognitive stress test, the Loewenstein-Acevedo Scales for Sematic Interference and Learning, Brief Computerized Version (LASSI-BC) could differentiate between Cognitively Unimpaired (CU) and amnestic Mild Cognitive Impairment (aMCI) groups. A second focus was to correlate LASSI-BC performance to volumetric reductions in AD-prone regions. Data was gathered from 127 older adults who were comprehensively evaluated and administered the LASSI-BC. Eighty-seven of these participants (51 CU; 36 aMCI) underwent MRI imaging. The volumes of 12 AD-prone brain regions were related to LASSI-BC and other memory indices correcting for False Discovery Rate (FDR). Results indicated that, even after adjusting for initial learning ability, the failure to recover from proactive semantic interference (frPSI) on the LASSI-BC differentiated between CU and aMCI groups. An optimal combination of frPSI and initial learning strength on the LASSI-BC yielded an area under the ROC curve of .876 (76.1% sensitivity, 82.7% specificity). Further, LASSI-BC measures of frPSI were associated with volumetric reductions in AD prone regions including the hippocampus, amygdala, inferior temporal lobes, precuneus and posterior cingulate.
Cloud Enterprise Dynamic Risk Assessment (CEDRA): a dynamic risk assessment using dynamic Bayesian networks for cloud environment
Authors: Behbehani Dawood , Komninos Nikos , Al-Begain Khaled , Rajarajan Muttukrishnan 
Published: May 2022

Abstract
Cloud computing adoption has been increasing rapidly amid COVID-19 as organisations accelerate the implementation of their digital strategies. Most models adopt traditional dynamic risk assessment, which does not adequately quantify or monetise risks to enable business-appropriate decision-making. To address this issue, we propose a Cloud Enterprise Dynamic Risk Assessment (CEDRA) model that uses CVSS, threat intelligence feeds and information about exploitation availability in the wild using dynamic Bayesian networks to predict vulnerability exploitations and financial losses. We evaluate the proposed model in a real case scenario that demonstrates the applicability of this model.
Synthesis and evaluation of novel flavonoid metal complexes as immune boosters for dual modulation of IL-6 pathway in SARS-CoV-2 therapy; A combined in-silico and in-vitro approaches
Authors: Akey swaroop Krishna , Patnaik Sunil Kumar , Vasanth P , Jeyaprakash  , Kumar Praharsh , Jawahar N , Selvaraj Jubie 
Published: May 2022

Abstract
It is observed that cytokine release syndrome (CRS) is one of the major causes for the death of several COVID-19 patients. Though several cytokines are involved in CRS, Interleukin-6 (IL-6) modulation plays a major role. We aim to develop new flavonoid metal complexes as immune boosters targeting IL-6 for SARS-CoV-2 treatment. To find potential flavonoids, PyRx 0.9 tool has been used to dock 152 secondary plant metabolites against IL-6 (PDB ID: 1ALU). The top scorer flavonoid (quercetin) was made into quercetin-oxime. Seven metal complexes (QM-1 to QM-7) were made from quercetin-oxime by utilizing divalent metals such as zinc, copper, magnesium, cobalt, barium, and cadmium. Based on ADME profile, it was assumed that all compounds were moderately soluble and would not penetrate the BBB. The in-vitro heamolytic research revealed a modest heamolytic effect in all seven complexes. To control the IL-6 inhibitory potential, complexes were screened for cytotoxicity in cell lines MCF-7 which predominantly expresses the IL-6 level. The cytotoxic effects of all complexes were considerable relative to the marketable Nutridac formulation. The complex quercetin-Zinc (QM1) and quercetin-Zinc-Ascorbic acid (QM7) significantly affected MCF-7 cells in concentrations 43.25 and 48.54 µg/ml, respectively.
Evaluation of the Mineral composition, Phytochemical and Proximate Constituents of three Culinary Spices in Nigeria: A Comparative Study
Authors: Evuen Uduenevwo Francis , Okolie Ngozi Paulinus , Apiamu Augustine 
Published: May 2022

Abstract
A comparative assessment of the quantitative mineral composition, phytochemical and proximate constituents of Xylopia aethiopica (fruits), Piper guineense (seeds) and Rhaphiostylis beninensis (roots) was done using standard protocols. Mineral analysis of the culinary spices revealed significant differences (p < 0.05) in the Magnesium, Zinc, Iron, Selenium, Copper, Calcium, Manganese, Molybdenum, Potassium and Sodium contents of the spices. The respective concentrations of Iron and Selenium (16.03 ± 0.01, 0.25 ± 0.01 mg/L) in R. beninensis were the highest and lowest of all mineral elements evaluated in the three spices. Similarly, the carbohydrate and moisture contents (81.24 ± 0.25%, 0.71 ± 0.01%) of R. beninensis were the highest and lowest among all proximate parameters evaluated in the three spices. However, the Fibre contents of R. beninensis and P. guineense and the ash contents of P. guineense and X. aethiopica respectively, showed no significant differences (p > 0.05). Moreover, flavonoid and oxalate concentrations (4.04 ± 0.09%, 0.25 ± 0.04%) in X. aethiopica were the highest and lowest of phytochemicals in the three spices respectively. Nevertheless, there were no significant differences (p > 0.05) in the tannin content of P. guineense and X. aethiopica spices respectively. Similar trends were observed between the oxalate contents of R. beninensis and X. aethiopica, the phytate contents of R. beninensis and P. guineense and the saponin contents of the three spices respectively. These results indicate that the spices are notable sources of essential nutrients and phytochemicals. Therefore, they are possible candidates in the search for natural ingredients to formulate drugs and nutraceuticals by pharmaceutical industries.
A Novel Application of Close-range Photogrammetry for Earth Retaining Wall and Slope Stability Assessment
Authors: Nategh Mehrdad , Ekinci Abdullah , Iravanian Anoosheh 
Published: May 2022

Abstract
In recent years, with the advances in the construction sector monitoring techniques have been extended to be used in geotechnical assets such as slopes, embankments, and retaining walls. The current study analyzed the slope stability problem near the Kyrenia Castel which belongs to the 7thcentury and is located in the northern part of Cyprus. In the current case, the landslide and RC/Stone walls built for rehabilitation purposes were monitored for a period of 2 years. As a conventional analysis method, the Finite Element Method (FEM) was adapted to back analyze the current condition of the site. On the other hand, close-range photogrammetry (CRP) was adopted by using an unmanned aircraft vehicle (UAV) to obtain the required photographs that are necessary to build the dense cloud model and detect the changes in geotechnical assets. The results show that the CRP method confirms the numerical analyses. As a result, this approach can be used vastly in various civil engineering applications, especially geotechnical engineering applications, as it is proven to be fast, cost-effective, and non-destructive when compared to conventional methods.
Cellxgene VIP unleashes full power of interactive visualization and integrative analysis of scRNA-seq, spatial transcriptomics, and multiome data
Authors: Li Kejie , Ouyang Zhengyu , Chen Yirui , Gagnon Jacob , Lin Dongdong , Mingueneau Michael , Chen Will , Sexton David , Zhang Baohong 
Published: May 2022

Abstract

To meet the growing demands from scientists to effectively extract deep insights from single cell RNA sequencing, spatial transcriptomics, and emerging multiome datasets, we developed cellxgene VIP (Visualization In Plugin), a frontend interactive visualization plugin of cellxgene framework, which greatly expanded capabilities of the base tool in the following aspects. First, it generates a comprehensive set of over eighteen commonly used quality control and analytical plots in high resolution with highly customizable settings in real time. Second, it provides more advanced analytical functions to gain insights on cellular compositions and deep biology, such as marker gene identification, differential gene expression analysis, and gene set enrichment analysis. Third, it empowers advanced users to perform analysis in a Jupyter Notebook like environment, dubbed Command Line Interface (CLI) by programming in Python and/or R directly without limiting themselves to functional modules available via graphical user interface (GUI). Finally, it pioneers methods to visualize multi-modal data, such as spatial transcriptomics embedding aligned with histological image on one slice or multiple slices in a grid format, and the latest 10x Genomic Multiome dataset where both DNA accessibility and gene expression in the same cells are measured, under the same framework in an integrative way to fully leverage the functionalities mentioned above. Taken together, the open-source tool makes large scale single cell data visualization and analysis more accessible to biologists in a user-friendly manner and fosters computational reproducibility by simplifying data and code reuse through the CLI. Going forward, it has the potential to become a crowdsourcing ecosystem for the scientific community to contribute even more modules to the Swiss Army knife of single cell data exploration tools.
Variability of Luminous QSOs following thermal timescale in standard thin accretion disk models
Authors: Tang Ji-Jia , Wolf Christian , Tonry John 
Published: May 2022

Abstract
We study the dependence of the stochastic variability of QSOs on luminosity, wavelength and thermal timescale in their accretion disks. We use over 5,000 of the most luminous known QSOs with light curves of almost nightly cadence spanning >5 years of observations from the NASA/ATLAS project, which provides 2 billion magnitude pairs for a bootstrap analysis. The results depend on which timescales are included in the analysis: when we only consider timescales >6 months, we find a robust behaviour for the whole sample. This behaviour is consistent with an un-damped random walk on the thermal timescales predicted by thin-disk models. We find a variability amplitude of log(A/A0) ≈1/2×log(Δt/tth). On shorter timescales, we observe a suppression of the amplitude due to light travel-time filtering, which could be used to measure sizes of accretion disks.
Influences of sleep and lifestyle factors on the risk for covid-19 infections: internet survey from 10,000 Japanese business workers
Authors: Nakashima Masahiro , Amano Ryota , Nishino Naoya , Osada Yasutaka , Watanabe Yuriko , Miyake Akifumi , Chiba Shintaro , Nishino Seiji 
Published: May 2022

Abstract
We conducted an internet survey to assess sociodemographic variables, lifestyle factors, sleep hygiene, and comorbidities for sleep apnea syndrome (SAS) in COVID-19 and influenza (FLU) infections. Data from 10,323 workers (50.0% male) were analyzed. COVID-19 was diagnosed in 144 subjects (COVID-19+), and 8,693 were classified as not suspected to be infected (COVID-19-). SAS had been diagnosed in 35.4% of the COVID-19+ subjects, but only 231 (2.7%) of the 8,693 COVID-19- subjects. COVID-19+ subjects were more susceptible to FLU (35.4%) compared to COVID-19- subjects (3.0%). A multivariate analysis revealed that higher risks of COVID-19+ were linked to the following factors: going out without a face mask (OR 7.05, 95% CI: 4.53-11.00), FLU+ (OR 6.33, 95% CI: 3.80-10.54), excessive exercise before going to sleep (OR 2.10, 95% CI: 1.63-2.70), SAS+ (OR 5.08, 95% CI: 2.88-8.94), younger age OR 1.05, 95% CI: 1.03-1.07), tendency for dozing off (OR 3.70, 95% CI: 2.30-5.95), and use of hypnotics (OR 2.28, 95% CI: 1.20-4.30). Since sleep impairment played a relatively small role in COVID-19+/SAS- subjects, we assume that SAS itself was a more significant risk factor for COVID-19 infection rather than sleep impairment. A better understanding of the mechanisms that result in increased susceptibility to COVID-19 in SAS is vital for helping prevent COVID-19.
Sociodemographic profile associated with perinatal depression during the COVID-19 era
Authors: Kovacheva Katina , Rodríguez-Muñoz Maria de la Fe , Gómez-Baya Diego , Domínguez-Salas Sara , Motrico Emma 
Published: May 2022

Abstract
Objective: Coronavirus disease (COVID-19) has caused an increase in perinatal depression. The aim of this research was to identify which sociodemographic variables are related to the increase in perinatal depression due to the pandemic. In addition to estimating to what extent they predict perinatal depression, differentiating the prenatal and postnatal period.Methods: The sample consisted of 3,356 subjects, 1,402 in the prenatal period and 1,954 in the postnatal period. The Edinburgh Postnatal Depression Scale was used to assess depressive symptomatology. A subset of 14 questions was included to collect demographic data. Items from the Spanish version of the Coronavirus Perinatal Experiences Survey were also included.Results: Experiencing the change of environment due to COVID-19 as negative and having a history of mental health predict perinatal depression, otherwise having higher education decreases the risk. In the prenatal stage having symptoms compatible with COVID-19 is a predictor of perinatal depression and having more than 3 years living together with the partner and being a housewife decreases the risk. In the postnatal stage being unemployed is a predictor of prenatal depression and being a first-time mother decreases the risk.Conclusions: This study highlights the relevance of sociodemographic status. It is essential to be aware of the risk factors of perinatal depression, to make adequate prevention and to create health policies to alleviate the consequences of the pandemic.
Sequential PET/CT and Pathological Biomarker Crosstalk Predict Response to PD-1 Blockers Alone or Combined with Sunitinib in Propensity Score-matched Cohorts of Cancer of Unknown Primary Treatment
Authors: Zeng Jiling , Ma Yifei , Wang Xinjia , Lv Jun , Wu Hao , Hu Ying-ying , Guo Qin Zhi 
Published: May 2022

Abstract
IntroductionImmune checkpoint inhibitors (ICIs), including toripalimab and pembrolizumab, have not been testified in treatment of cancer of unknown primary, which has a very poor prognosis. Combined with anti-angiogenic therapies, ICIs are hypothesized to be effective in prolonging overall survival. The study aims to give evidence on the treatment effects of sunitinib combined with ICIs, find pathological biomarkers associated with changes in volumetric PET/CT parameters, and interrogate inner associations among these markers associated with response on PET/CT.MethodsThe study recruited patients receiving combined treatment (ICIs + sunitinib) and compare the effects with separate treatment and with age-matched negative controls, analyzed in propensity score-matched (PSM) pairs. Markers associated with survival were identified and their inner associations were tested with structural equation modeling.ResultsA total of 292 patients were enlisted in the final analysis with 53 patients receiving combined treatment. Survival analysis demonstrated significantly prolonged survival in either combined or separate treatment, with the combined arm showing better response when PSM-paired by pre-treatment whole-body PET/CT parameters. Angiogenic marker KDR and VEGF mediates the PD-1 blockade impact on volumetric value changes, in positive and negative manners, respectively.ConclusionAnti-angiogenic agents sunitinib may potentiate PD-1 blockade by diminishing angiogenesis or its downstream effects. The combined separate treatment increased survival of CUP patients and the responses could be evaluated by volumetric PET/CT parameters.
Continuous estimates of heat emission at Mt. Ruapehu using the Unscented Kalman Smoother
Authors: Behr Yannik , Sherburn Steve , Hurst Tony 
Published: May 2022

Abstract
Volcanic lakes often capture a significant amount of volcanic heat emission and thus provide a unique opportunity to monitor changes inside the volcano. We present a Bayesian inversion method to automatically infer volcanic heat emission at the base of a volcanic lake from lake monitoring data using a non-linear Kalman Smoother. Our method accounts for the, sometimes large, uncertainties in observations and the underlying physics-based model to generate probabilistic estimates of heat emission. We verify our results using a synthetic test case and then estimate the daily heat input rate into Mt. Ruapehu’s Crater Lake, New Zealand, between 2016 and 2022. Time-frequency analysis of the heat input rate shows dominant periods of heating cycles ranged between 100-250 days. The period between 2017 and 2020 was dominated by shorter cycles and greater-than-average heat input rate which points to changes in the magmatic heat supply and the hydrothermal system during this time.
Investigating the white matter tract pattern in ADHD compared to healthy controls
Authors: Valizadeh Parya , Jannatdoust Payam , Anvarnia Yasaman , Rahnama Yassin , Shafie Mahan , Sadeghi Mohammad , Pezeshki Parmida , Aarabi Mohammad Hadi , Mayeli Mahsa 
Published: May 2022

Abstract
Objective : Previous Diffusion Tensor imaging (DTI) studies have revealed microstructural alterations in white matter (WM) tracts among children with attention deficit hyperactivity disorder (ADHD). Although ADHD can persist into adulthood in more than half of the diagnosed children, few studies have investigated the WM tracts in adults with ADHD. In this study, the emphasis is placed on the adult population with regard to WM abnormalities.
Method : Using the UCLA Consortium for Neuropsychiatric Phenomics (CNP) dataset, we compared the microstructural indices of tracts of interest between ADHD subjects and healthy controls.
Results: In the ADHD group, both fractional anisotropy (FA) and generalized fractional anisotropy (GFA) were lower than the control group in Right Cingulum Rarolfactory, Corpus Callosum (CC) Forceps Major, and Right Superior Longitudinal Fasciculus1 (SLF1). Diffusivity indices, including mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), were increased in widespread WM tracts. However, only RD and FA in CC Forceps Major remained significantly different between two groups after correction for multiple analysis. Interestingly, our analysis found increased NQA in all tracts of interest, except for the left fornix.
Conclusion : This study revealed several WM abnormalities in certain tracts of the limbic system, SLF1 and, most noticeably, CC in adults with ADHD. These findings, along with the finding of altered NQA, suggest the need for further study to determine the neurophysiological basis of the disease.
Rivers as witnesses of Titan's latitudinal climate variability
Authors: Daudon Chloe , Rodriguez Sébastien , Devauchelle Olivier , Lajeunesse Eric , Lucas Antoine , Jacquemoud Stéphane 
Published: May 2022

Abstract
Titan's rich and dense atmosphere, composed mainly of methane and nitrogen, maintains a methane cycle that shapes its surface, like the water cycle on Earth. Methane precipitations erodes Titan's surface and forms complex river networks observed at all latitudes by the Cassini-Huygens mission. However, precipitation rates are poorly constrained and, in the absence of in situ measurements, understanding Titan’s global climate and meteorology is done primarily through climate models. Here, we apply a physics-based theory of river morphogenesis to provide new constraints on methane precipitation rates. In particular, we estimate the river discharges and precipitation rates required to shape two methane rivers located at the equator and south pole, which incise the surface of Titan. Our results show that the use of river morphology is relevant for inferring methane precipitation rates at various latitudes. Our estimates reduce the uncertainties from the climate models. In addition, our results reflect the climate variability between the equator and the south pole. Finally, this work sheds the light to unknown river on Earth: the giant gravel-bed rivers.
An observational study of temporomandibular joints in adults with definite sleep bruxism on magnetic resonance imaging and cone beam computer tomography images
Authors: Zhang Juan , Yu Wenjuan , Wang Jianghong , Wang Sijia , Li Yifan , Jing Huimin , Li Zekui , Li Xin , Liang Meng , Wang Yonglan 
Published: May 2022

Abstract
BackgroudThe aim was to comprehensively study the imaging characteristics of temporomandibular joint (TMJ) soft and hard tissues of definite sleep bruxers through magnetic resonance imaging (MRI) and cone-beam computer tomography (CBCT).Methods19 definite sleep bruxers diagnosed by Polysomnography (the study group) and 20 asymptomatic non-bruxers (the control group) matched with age, gender, Body Mass Index, and education level participated in this study. After obtaining MRI and CBCT images of all TMJs of the subjects, evaluation and measurement were conducted according to the unified standard respectively. The analyzed parameters included disk position, disc configuration, joint effusion (JE), joint space or condyle position, and condylar bony changes.ResultsOf the 38 joints in the study group, disc deformity and disc displacement of TMJs were both 57.9% when mouth closed, 39.5% and 34.2% showed banded and linear effusion respectively, and 76.3% showed condylar bony changes. While when mouth opened, 82% of all TMJs showed physiological biconcave discs. Comparison of joint space between the two groups revealed that the anterior space was larger in the study group, and 65.8% of condyles were located in the posterior. However, there was no significant difference between the mild and the moderate to severe sleep bruxism subgroups in the changes of TMJ soft and hard tissues (P > 0.05).ConclusionsThe results demonstrated that a higher prevalence of disc deformity, disc displacement, JE and condylar bony changes occurred in temporomandibular joints of sleep bruxers. Nevertheless, these changes were not related to the severe of sleep bruxism.