bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Analysis of hepatocellular carcinoma patients with segmental portal vein tumor thrombus after deceased donor liver transplantation: a long-term retrospective study
Authors: Sha Meng , Chen Chen , Shen Chuan , Jeong Seogsong , Sun Han-yong , Xu Ning , Hang Hua-lian , Cao Jie , Tong Ying , Xia Qiang 
Published: June 2022

Abstract
Background
Hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) have conventionally been regarded as a contraindication for liver transplantation (LT). However, the outcomes of deceased donor liver transplantation (DDLT) in patients with segmental PVTT remain unknown. The aim of this study is to evaluate the feasibility and effectiveness of DDLT in the treatment of HCC with segmental PVTT.
Methods
We retrospectively analyzed 254 patients who underwent DDLT for HCC in our institution from January 2015 to November 2019. To assess the risks of PVTT, various clinicopathological variables were evaluated. Overall (OS) and recurrence-free survival (RFS) analyses based on different PVTT types were performed in HCC patients.
Results
Of the 254 patients, a total of 46 patients had PVTT, of whom 35 had lobar PVTT and 11 had segmental PVTT in second-order branches or below. Alpha-fetoprotein (AFP) level, tumor maximal diameter, histological grade, micro-vascular invasion (MVI), RFS, and OS were significantly different between the control and PVTT groups. Lobar PVTT was associated with unfavorable 5-year RFS and OS compared with MVI group (28.6% and 17.1%, respectively). Instead, no significant difference was observed between the segmental PVTT and MVI group in terms of 5-year RFS and OS (RFS: 36.4% vs. 40.4%, p = 0.667; OS: 54.5% vs. 45.1%, p = 0.395). Further subgroup analysis showed segmental PVTT with AFP levels ≤ 100 ng/ml presented significantly favorable RFS and OS rates than those with AFP level > 100 ng/ml (p = 0.050 and 0.035, respectively).
Conclusions
In summary, lobar PVTT in first-order branches remains a contraindication to DDLT. HCC patients with segmental PVTT and AFP level ≤ 100 ng/ml may be acceptable candidates for DDLT.
One step dual template facile synthesis of Micro-Mesoporous ZSM-5 Composite and its application in 5-(ethoxymethyl)furfural (biofuel additive) synthesis
Authors: Manal Prajakta N. , Niphadkar Prashant S. , Nandanwar Sachin U. , Bokade Vijay V. 
Published: June 2022

Abstract
The preparation of micro-mesoporous zeolite with controlled mesoporosity is an expanding area of research having advantages in term of the creation of mesoporosity by preserving crystallinity of zeolite; converting bulky molecules to valuable products etc. The present work is a successful attempt to synthesize micro-meso ZSM-5 composite in one step using cheaper silica (sodium silicate) and alumina (aluminiumsulphate) as source material with dual templates (CTMABr and TPABr). The insitu mesoporous creation in a controlled way by using these source materials is rarely reported. The facile one-step synthesis of micro-mesoporous ZSM-5 composite feature dual Meso/microporosity by the marginal decrease in crystallinity(71%)and mesoporous creation in micro-ZSM-5 found to be depend on optimum CTMABr/SiO2 molar ratio in the range of 0.04 to 0.06. The micro-mesoporous ZSM-5 composite zeolite was evaluated for cascade synthesis of 5-EMF (ethoxymethyl furfural- biofuel additive) from fructose, exhibited 5 fold increase in EMF yield of 24.2% than micropous ZSM-5 4.6%.
Synthesis, Characterization And Larvicidal Activity Of Schiff Base Ligand 5-(((5-mercapto- 1,3,4-thiadaizol-2-yl)imino)methyl)-2-methoxyphenol And Its Metal(Ii) Complexes
Authors: Deepika P , M Vinusha H. , Begum Muneera , Rekha N D 
Published: June 2022

Abstract
In the current work we have synthesized a Schiff base ligand 5-(((5-mercapto-1,3,4-thiadaizol-2-yl)imino)methyl)-2-methoxyphenol (HL) derived from the condensation of 5-amino-1,3,4-thiadaizole 2- thiol and 3-hydroxy-4-methoxy benzaldehyde and its Cu(II), Mn(II) and Zn(II) metal complexes in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and its metal complexes were evaluated using MS technique, FT-IR, UV-Visible, 1H-NMR, 13C-NMR and thermogravimetric analysis. The larvicidal bioassay were also done for all the metal complexes and Schiff base ligand. The mortality of the larvicidal activity were also determined.
Prolonged usage of fosaprepitant for prevention of delayed CINV in patients receiving highly emetogenic chemotherapy
Authors: Gao# Ai , Guan# Shasha , Sun Yinjuan , Wang Lingling , Meng Fanlu , Liu Xia , Gu Liyan , Li Guo , Zhong Diansheng , Zhang Linlin 
Published: June 2022

Abstract
Background: Even though chemotherapy-induced nausea and vomiting (CINV) can be well controlled in the acute phase, the incidence of delayed CINV remains high. In this study, we intend to investigate whether prolonged use of NK-1 receptor antagonist (RA) in addition to 5-HT3 RA and dexamethasone (DEX) was more effective in preventing delayed CINV.Methods: This study was designed to compare the efficacy and safety of fosaprepitant 150 mg given on days 1,3 (prolonged group) versus on day 1 (regular group) in patients receiving highly emetogenic chemotherapy (HEC). All patients also treated with palonosetron on day 1 and DEX on days 1-4. The primary endpoint was the incidence of delayed nausea and vomiting. The second endpoint was related AEs. All the above endpoints were defined according to CTCAE 5.0.Results: Seventy-seven patients were randomly assigned to prolonged group and seventy-nine to regular group. Prolonged group demonstrated superiority in controlling delayed CINV to regular group, with statistically significant lower incidence of nausea (6.17% vs 12.66%, P=0.0056), and slightly lower incidence of grade 1 vomiting (1.62% vs 3.80%, P=0.0953) in the delayed phase. In addition, prolonged use of fosaprepitant was safe. No significant difference was found between the two groups regarding constipation, diarrhea, hiccough, fatigue, palpitation and headache in delayed phase.Conclusions: Prolonged use of fosaprepitant can effectively and safely prevent delayed CINV in patients receiving HEC.
A Novel Fully Convolutional Neural Network Approach For Detection and Classification of Attacks on Industrial IoT Devices in Smart Manufacturing Systems
Authors: Shahin Mohammad , Chen F. Frank , Bouzary Hamed , Hosseinzadeh Ali , Rashidifar Rasoul 
Published: June 2022

Abstract
Recently, Internet of things (IoT) devices have been widely implemented and technologically advanced in manufacturing settings to monitor, collect, exchange, analyze, and deliver data. However, this transition has increased the risk of cyberattacks, exponentially. Subsequently, developing effective intrusion detection systems based on deep learning algorithms has proven to become a reliable intelligence tool to protect Industrial IoT devices against cyber threats. This paper presents the implementation of two different classifications and detection utilizing the Long Short-Term Memory (LSTM) architecture to address cyber-security concerns on three benchmark Industrial IoT datasets (BoT-IoT, UNSW-NB15, and TON-IoT) which take advantage of various deep learning algorithms. An overall analysis of the performance of the proposed models is provided. Augmenting the LSTM with Convolutional Neural Network (CNN) and Fully Convolutional Neural Network (FCN) achieves state-of-the-art performance in detecting cybersecurity threats.
Objective Structured Assessment Ultrasound Skill Scale for Hyomental distance competence – psychometric study
Authors: Gomes Sara Hora , Trindade Marta , Petrisor Cristina , Costa Dinis , Pêgo José M. , Correia-Pinto Jorge , Costa Patrício S. 
Published: June 2022

Abstract
Background: Ultrasound assessment of the airway recently integrates the point-of-care approach to patient evaluation since ultrasound measurements can predict a difficult laryngoscopy and tracheal intubation. Because ultrasonography is performer-dependent, a proper training and assessment tool is needed to increase diagnostic accuracy. An objective, structured assessment ultrasound skill (OSAUS) scale was recently developed for different medical fields. The work aims to study the psychometric properties of OSAUS Scale when used to evaluate competence in ultrasound hyomental distance (HMD) measurement. Methods: Prospective and experimental study. Fifteen volunteers were recruited and divided into three groups depending on participants expertise in airway ultrasound. Each participant performed ultrasonographic HMD evaluation, with the patient in head neutral and extended position, in 3 standardized patients. The performance was videorecord and anonymized. Five assessors blindly rated participants’ performance using OSAUS scale and a Global Rating Scale (GRS). A psychometric study of OSAUS scale as assessment tool for ultrasound HMD competence was done. Results: Psychometric analysis of OSAUS showed strong internal consistency (Cronbach’s alpha 0.916) and inter-rater reliability (ICC 0.720; p<0.001). The novice group scored 15.4±0.08 (mean±SD), the intermediate 14.3±0.33 and expert 13.5±0.68, with a significant difference between novice and expert groups (p=0.036). The time in seconds to complete the task was evaluated: novice (90.40±34.15) (mean±SD), intermediate (84.20±22.88) and experts (82.60±15.07), with no significant differences between groups. A strong correlation was observed between OSAUS and global rating scale (r=0.970, p<0.001). Conclusions: The study demonstrated evidence of validity. Further studies are needed to move forward to implement OSAUS scale in the clinical setting for training and assessment of airway ultrasound competence.
Obstetric violence and associated factors among HIV-infected women receiving birth care at Public Health Facilities in Addis Ababa, Ethiopia
Authors: Assefa Anteneh Wondimagegn , Ayele Basha , Masersha Seteamlak Adane 
Published: June 2022

Abstract
Background: Obstetrics violence is the adverse outcome of maternal and prenatal health. In the study context, there was limited data on obstetrics violence among HIV infected women. Therefore, the aim of this study to assess obstetric violence and its associated factors among HIV-infected women receiving birth at public health facilities in Addis Ababa Ethiopia. Methods: Institutional base cross-sectional study was conducted from Jan 1-30, 2021 at selected public health facilities in Addis Ababa Ethiopia. Thereafter, all covariates with p-value <0.2 is a cutoff points for bivariate analysis were considered for further multivariate logistic regression. Finally level of stastical significant were declared at p value <0.05. Result: A total of 318 HIV-infected women were participated in this study yielding 100% response rate. All type/form of obstetric violence were reported during the study period. Accordingly, Female birth attendant (AOR= 2.848; 95% CI 1.574, 5.153), women who had three times ANC-visitors (AOR= 2.994; 95% CI 1.390, 6.449), women age >35 years old (AOR= 2.471; 95% CI 1.245, 4.904) and women education primary school (AOR= 2.126; 95% CI 1.084, 4.170) were significantly associated with obstetric violence. Conclusion: This study indicated that the prevalence of obstetric violence among HIV infected women was high. Therefore, to reduce violence during birth care by ensuring clear policies and ethical standards of birth care will be develop and implement and also to rise quality of maternal birth care through an inclusive process by involving the participation all families and stakeholders.
Effects of Feeding Artemia sp. and Artificial Feed Enriched with Bacillus sp. NP5 to Catfish Pangasianodon hypophthalmus on Growth Performance, Immune Responses, and Resistance to Aeromonas hydrophila Infection
Authors: Widanarni Widanarni , Aswandi Diar Setiawan , Rahman Rahman , Munaeni Waode 
Published: June 2022

Abstract
Motile Aeromonad Septicemia (MAS) is caused by Aeromonas hydrophila and often attacks juvenile catfish. Probiotics could be an alternative to prevent MAS disease. This study aims to determine the dose of probiotics to improve the survival, growth performance, and immune response of juvenile catfish Pangasianodon hypophthalmus to the A. hydrophila infection. This probiotic was contained in Artemia sp. and artificial feed enriched with Bacillus sp. NP5 at concentrations of 106 CFU.mL-1, 107 CFU.mL-1, 108 CFU.mL-1, and the control. Larvae with an average weight of 1.52 ± 0.06 mg and an average length of 0.46 ± 0.007 cm were reared for 28 days in aquariums filled with 10 L of water and a stocking density of 15 individuals.L-1. After the rearing period, the fish was challenged by the immersion of A. hydrophila with a concentration of 107 CFU.mL-1. This study has revealed that probiotics could increase the fish’s survival, length growth, daily growth rate, and feed conversion ratio. The total bacterial count in larvae and probiotics in juvenile fish is higher than those in the control. After the fish had been challenged with the probiotics at a concentration of 108 CFU.mL-1, they had a better survival rate and immune responses (including leukocyte differential, phagocytosis activity, and respiratory burst activity) than the positive control. Probiotic Bacillus sp. NP5 is effectively administered through bioencapsulated Artemia sp. and commercial feed.
Genetic deletion of HPV E7 oncogene effectively eliminates HPV driven oropharyngeal cancer tumours
Authors: Idris Adi , McMillan Nigel , Ferreira Danyelle 
Published: June 2022

Abstract
The major HPV oncogenes E6 and E7 are known for its notoriety in driving the carcinogenic process in human papilloma virus (HPV) driven cancers. It is well-established that the removal of E7 dampens HPV cancer cell growth and proliferation. This has made E7 one of the most attractive targets for HPV cancers. Seminal work from our laboratory employed in vivo CRISPR editing treatment to delete E7, resulting in the effective elimination of HPV positive (HPV+) cervical cancer tumours in vivo. We have also successfully delayed HPV+ tumour growth in vivo with aurora kinase (AURK) inhibitors, an effect which is strongly sensitized by the presence of E7 expression. Unlike our observations in cervical cancer cells, in vitro targeting of E6/E7 have only resulted in partial killing of HPV+ oropharyngeal cancer (OPC) cells. The effect of E7 removal on HPV+ OPC tumours in vivo have not been explored. In this study we investigated a staggered combination of aurora kinase inhibition, using alisertib, followed by CRISPR editing of E7, to determine if this would lead to better HPV+ OPC cell killing in vitro and in vivo. Remarkably, genetic deletion of E7 alone was sufficient to effectively eliminate established HPV+ OPC tumours in vivo suggesting that E7 is essential in the maintenance of HPV+ OPC cancers.
Mesoporous titania-ceria mixed oxide (MTCMO) catalyzed one-pot green synthesis and antibacterial activity of diethyl (((4-(N-(5-methyl-4, 5- dihydroisoxazol-3-yl)sulfamoyl)phenyl)amino)(substituted methyl) phosphonates
Authors: Shaik Yasmin Haroon , Sarva Santhisudha , Gundluru Mohan , John Ashwini , Ethiraj Selvarajan , Cirandur Suresh Reddy 
Published: June 2022

Abstract
An efficient green synthesis of diethyl (((4-(N-(5-methyl-4,5-dihydroisoxazol-3-yl)sulfamoyl)phenyl)amino)(substituted methyl) phosphonates was accomplished by the condensation of 4-amino-N-(5-methyl-4,5-dihydroisoxazol-3yl)benzenesulfonamide with various aldehydes and diethyl phosphite using mesoporous titania-ceria mixed oxide (MTCMO) as a nano-catalyst under microwave irradiation and solvent free conditions. Antimicrobial activity was performed for the synthesized compounds and the compounds 4a, 4c, 4d, 4e and 4f exhibited highest inhibitory activity against Escherichia coli and Bacillus subtilis using Penicillin and Tetracycline as standards.
Peak Flow Prediction and Hydrologic Hazard Assessment for Kessem Dam by Using Machine Learning Models and RMC-RFA Software
Authors: Ergete Esayase Tesfaye , Ayele Elias Gebebeyhu 
Published: June 2022

Abstract
In dam systems, flooding is a peak flow that the major problem and cause of dam failure in the form of overtopping phenomena, especially for embankment dams. A quantitative hydrologic risk assessment of the dam is used for dam safety evaluation in deciding whether existing structures provide adequate levels of safety, and if not, what modifications are justified to improve the dam's safety. This study considered the Kessem River watershed of the Awash basin, located at 9o8’45" latitude and 39o55'31" longitude at the southern end of the Afar rift in the Afar region of Ethiopia, and focused on the powerful method of prediction peak inflow to the reservoir, including the semi-quantitative assessment of hydrologic hazard for Kessem Dam using machine learning predictive models and RMC-RFA software. The most recent three RNN (LSTM, Bi-LSTM, and GRU) machine learning predictive models with hybrid to SCS-CN model were used for simulation of Kessem river flow. Peak daily inflow events to the reservoir are predicted to be 467.72 m3/s, 435.88 m3/s and 513.55 m3/s in 2035, 2061, and 2090, respectively. The hydrologic hazard analysis results show that 2,823.57 m3/s and 935.21 m, 2,126.3 m3/s and 934.18 m, and 11,491.1 m3/s and 942.11 m peak discharge and maximum reservoir water level during the periods of 2022–2050, 2051–2075, and 2076–2100, respectively, for 0.0001 APE. As concluded, Kessem dam may potentially be overtopped by a flood with a return period of about 10,000 years during the period of 2076–2100. So, the dam required further risk analysis study and dam safety modification in order to control this probable failure mode during the indicated time.
TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex
Authors: Kawabata Ryo , Yao Ikuko , Arata Akiko , Koga Kohei 
Published: June 2022

Abstract
Transient receptor potential ankyrin 1 (TRPA1) is a member of the TRP channel family and is expressed in peripheral and central nervous systems. In the periphery, TRPA1 senses cold and pain. However, the functions of TRPA1 in the CNS are unclear. Here, we examined the roles of TRPA1 on neural activity and synaptic transmission in layer II/III pyramidal neurons from mice anterior cingulate cortex (ACC) by whole-cell patch-clamp recordings. The activation of TRPA1 produced inward currents that were blocked by the TRPA1 antagonist. Furthermore, activating TRPA1 changed the properties of action potentials such as the frequency, rise time and decay time. In contrast, stimulating TRPA1 did not alter the spontaneous synaptic transmission. Finally, we examined the functional role of TRPA1 on neurons in a hypoxic environment. We induced an acute hypoxia by substituting nitrogen (N2) gas for oxygen (O2) in the external solution. N2 produced biphasic effects that consisting of inward currents in the early phase and outward currents in the late phase. Importantly, blocking TRPA1 reduced inward currents, but not outward currents. In contrast, a KATP channel blocker completely inhibited outward currents. These results suggest that TRPA1 acts on postsynaptic neurons in the ACC as an acute O2 sensor.
Low Cost Novel Supplementation of Anionic Salts to Reduce the Incidence of Economically Important Milk Fever Disease in Transition Cows
Authors: Gunasekaran S. , Radharishnan L. , sundaram S. Meenakshi 
Published: June 2022

Abstract
A feeding trial was conducted in 16 transition cows (farm and field conditions) to increase the serum calcium level through feeding anionic salts and reducing the positivity of the diet. Anionic salts were supplemented based on assessing the Dietary Cationic and Anionic Difference (DCAD) value of the feed and fodders offered to the animals affected with milk fever in Kancheepuram district of Tamil Nadu. DCAD value of the ration of all experimental cows was adjusted to -15 to -10 mEq/100g dry matter by supplementation of anionic salts viz., calcium sulphide and magnesium chloride along with hydroponic fodder bajra. Anionic salts supplementation for three weeks prior to calving resulted in significant (P<0.05) increase in the serum calcium levels in all 16 cows. In post supplementation, average increase in the serum calcium level is 0.93 mg/dl, an increase by 10.80 per cent.
Design, characterization and preliminary usability testing of a portable robot for unsupervised therapy of hand function
Authors: Ranzani Raffaele , Albrecht Martin , Haarman Claudia , Koh Emily , Devittori Giada , Held Jeremia P.O. , Tönis Frederik , Gassert Roger , Lambercy Olivier 
Published: June 2022

Abstract
Background: There is evidence that increasing therapy dose after stroke might promote recovery. Unfortunately, in clinical practice, therapy dose is limited by financial and organizational constraints. Simple, scalable, robotic devices that could be used with minimal to no supervision in the clinic or at home bear the promise of increasing dose without requiring additional resources. For this purpose, we developed HandyBot, a portable three-degrees-of-freedom end-effector haptic device to perform sensorimotor task-oriented therapy of hand function (i.e., grasping, forearm pronosupination, wrist flexion-extension) in different environments (e.g., clinic, home). Methods: In this paper we present the design of the device and its technical evaluation in terms of workspace, dynamics (i.e., max end-effector velocity, acceleration and force), sensing (i.e., position, velocity and force resolution) and haptic performance (i.e., transparency, maximum stable impedance range, rigid contact rendering accuracy). Furthermore, its usability was assessed in terms of System Usability Scale (SUS) in a single-session pilot study with four subjects with chronic stroke that tested the HandyBot therapy platform (i.e., haptic device with a graphical/physical user interface and a set of therapy exercises) while simulating unsupervised use (i.e., the subject used the device independently but a therapist was observing the session for study purposes). Results: HandyBot showed hardware and control performances comparable to other less portable therapy devices for hand function (e.g., 94% accuracy in stiffness rendering, device transparency increased by 69.14% with impedance control), making it a suitable platform for the implementation of engaging sensorimotor therapy exercises. HandyBot showed good platform usability in terms of SUS (i.e., above 75 out of 100 for device and graphical user interfaces, above 65 out of 100 for the exercises) when tested in simulated unsupervised settings. These tests could underline minor design improvements that should be considered to allow the use of such devices in uncontrolled settings. Conclusions: HandyBot is usable at first exposure and could support the implementation of unsupervised robot-assisted sensorimotor therapy of hand function. This therapy approach combined with this novel portable robotic device may help maximize therapy dose and decrease therapy-associated costs (e.g., therapist time to therapy time ratio) in different environments.