bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study of K-wire combined with screw vs. K-wire in the treatment of AO type B3.1 phalangeal fractures
Authors: Ma Xuelin , Wang Li , Zhang Xiaoran , Zhang Zhemin , Xu Yali , Lv Li , Shao Xinzhong 
Published: April 2022

Abstract
Purpose: The purpose of this study was to introduce the surgical method of K-wire combined with screw in the treatment of Arbeitsgemeinschaftfür Osteosynthesefragen (AO) type B3.1 phalangeal fractures and to compare its clinical, radiological and functional outcomes with K-wire fixation.Methods: This was a retrospective comparative study. From January 2015 to February 2022, we treated 86 patients with AO type B3.1 phalangeal fractures. A total of 71 patients were finally included in the statistical analysis. Thirty-nine patients received K-wires combined with screw, and 32 patients received simple K-wires. The follow-up time was at least 6 months. Outcome measures included general information, operative time, total active motion (TAM), pinch strength, radiological union time, pain assessed by visual analog scale (VAS), Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score, and complications.Results: The follow-up time was 6-12 months, with an average of 7.9 months. All patients achieved clinical and radiological union. Compared with the K-wire fixation group, the TAM, radiological union time and VAS score of the K-wire combined with screw group had obvious advantages. Compared with the opposite healthy hand, the grip strength of the two groups was similar, and there was no significant difference in the QuickDASH score. The incidence rate of complications in the K-wire combined with screw group (2/39) was lower than that in the K-wire fixation group (7/32).Conclusions: Compared with simple K-wire fixation, K-wire combined with screw in the treatment of AO type B3.1 phalangeal fractures is a safer and reliable surgical method. K-wire controls the rotation and plays a role similar to a "lock". The screw can exert pressure and fix it more firmly. It shortens the time of fracture healing and has a higher TAM and fewer postoperative complications.
The effect of Medicago sativa extract and light on skin hypopigmentation disorders in C57/BL6 mice
Authors: Ubaydee Azal Hussein Najm , Issa Reem , Hajleh Maha N. Abu , Ghanim Bayan Y. , Al-Akayleh Faisal , Qinna Nidal A. 
Published: April 2022

Abstract
Vitiligo is a common depigmentation skin disease that affects the quality of life in many patients. This study aims to investigate the effect of Medicago sativa methanol extract on the treatment of skin hypopigmentation disorders. Antioxidant activity and phytochemical constituents of the extract were determined using DDPH assay, Folin-Ciocalteu, AlCl3 and HPLC-MS/MS analysis. Oil in water (o/w) creams were prepared to contain the methanolic extract, and applied to hydroquinone-induced depigmentation in vivo model and further challenged in combination with UVA light exposure. Skin and hair colors were visually scored and evaluated at different time intervals, and histopathological examinations of skin layers and hair follicles were performed. Results showed total phenolic content of 187.70 mg/g, equivalent to gallic acid, and total flavonoid content of 21.97 mg/g, equivalent to quercetin. Most interestingly, the extract showed an antioxidant percent inhibition activity of 71%. Moreover, the HPLC-MS/MS detection revealed the presence of 18 compounds including P-coumaric acid and antioxidants flavonoids, of those are 7 compounds not previously detected in this species. The in vivo study showed a remarkable skin and hair pigmentation effect on plant extract treated groups, compared to the reference, placebo and control groups. Histopathological examinations showed the growth of coloured hair follicles in the dermis and epidermis layers of the extract treated mice. In conclusion, the study suggests the use of M. sativa extract in enhancing the pigmentation process in hypopigmented skin and hair if combined with UVA light. Therefore, M. sativa extract can be considered a potential treatment for vitiligo.
3,3’-Diindolylmethane inhibits ovarian cancer cell viability and enhances chemotherapy sensitivity via STAT3 Pathway
Authors: Zou Minghua , Zeng Chuan 
Published: April 2022

Abstract
Purpose Ovarian cancer is the leading cause of gynecologic cancer deaths among women. 3, 3’-diindolylmethane(DIM), a small molecule compound, is a proposed cancer preventive agent without causing toxicity to normal cells. Signal transducer and activator of transcription-3 (STAT3)was constitutively activated in ovarian cancer .In the present study, we aimed at investigate the potential effects of DIM on ovarian cancer cells and observe the effects of the combination of STAT3 gene silencing and DIM on cell viability, cell-cycle regulation, and sensitivity to chemotherapy. Methods Ovarian cancer SKOV3 and A2780 cell lines were treated with various concentrations of DIM for different periods of time for assessment of cell viability, and sensitivity to chemotherapy as well as gene expression before and after knockdown of STAT3 expression using STAT3 shRNA. Results The study find DIM treatment potently suppressed abilities of ovarian cancer cell viability, also induced cisplatin sensitivity. At the gene level, DIM inhibited phosphorylation of STAT3 proteins and expression of its downstream proteins. Moreover, knockdown of STAT3 expression significantly enhanced DIM antitumor activity and cisplatin sensitivity. In addition, their combination suppressed expression of survivin, Bcl-2, Mcl-1, but upregulated expression of Caspase3. Conclusions Our findings suggest DIM antitumor activity was to inhibit the STAT3 signaling pathways. The combination of STAT3 knockdown with DIM treatment could be further evaluated as a therapeutic strategy for treatment of advanced ovarian cancer.
Rapid Relapse of Symptomatic SARS-CoV-2 Infection Following Early Suppression with Nirmatrelvir/Ritonavir
Authors: Gupta Kalpana , Strymish Judith , Stack Gary , Charness Michael 
Published: April 2022

Abstract
Initiation of NM/R treatment on Day 0 in a 71-year-old vaccinated and boosted male resulted in rapid resolution of COVID-19 symptoms followed one week later by the development of typical cold symptoms. SARS-CoV-2 viral load fluctuated in parallel with symptoms, with two distinct peaks on Day 1 and Day 9 of illness. No other respiratory pathogens were identified. Viral samples demonstrated sequence identity for the omicron subvariant BA.1 on Days 1, 7, and 11. Our findings suggest that viral replication and COVID-19 symptoms may recur after very early treatment with NM/R before natural immunity is sufficient to fully clear SARS-CoV-2.
Graves disease – induced immune thrombocytopenic purpura in an african female: a case report
Authors: Agyapong Kwabena Oteng , Folson Aba , Fiador Kate , Kootin-Sanwu Cecilia , Tufuor Martha , Bampoh Sally Afua , Fiscian Henrietta , Wonkyi Roland 
Published: April 2022

Abstract
BackgroundImmune thrombocytopenic purpura (ITP) is a condition associated with an unusual, unexplained, and sometimes very severe reduction in the level of platelets in the blood. Its association with Graves’ disease, though documented, is not very common and can easily be missed or misdiagnosed, leading to excessive bleeding and mortality. Treatment with steroids and anti-thyroid medications has been shown to be beneficial in correcting thrombocytopenia in these patients, although the response is varied. We report on a patient with Graves’ disease who presents with ITP.Case presentationThe patient is a 37-year-old Ghanaian female who presented to our hospital’s emergency department with a complaint of palpitations, difficulty breathing, easy fatigue, and headaches. She had been referred from a peripheral hospital as a case of thrombocytopenia, severe anemia, and anterior neck swelling. She was diagnosed with Graves’ disease 2 years ago, became euthyroid in the course of treatment, but defaulted. On further examination and investigation, she was diagnosed with immune thrombocytopenic purpura and was also found to have elevated free T3, T4 and suppressed TSH. She also had high thyroid autoantibodies. She was initially started on oral prednisolone but there was no stabilisation of platelets until methimazole was introduced, which improved and normalised her platelet count.ConclusionThe association of Graves’ disease with immune thrombocytopenic purpura, though documented, is uncommon and very few cases have been reported thus far. There has not been any reported cases in Ghana or sub-Saharan Africa and hence, clinicians should be aware of this association when investigating for ITP and should consider graves’ disease as a possible cause. From this study, we observed that there was no improvement in platelet count following the use of corticosteroid therapy until methimazole was started.
A Ketogenic Diet is Effective in Improving Insulin Sensitivity in Individuals
with Type 2 Diabetes
Authors: Skow Samantha L. , Jha Rajesh Kumar 
Published: April 2022

Objective:
This systematic review looked at different clinical trials that explored the
beneficial effect of a ketogenic diet on insulin sensitivity in Type 2 Diabetics, both with and without
exercise. It was hypothesized that a ketogenic diet is effective in improving insulin sensitivity
in individuals with Type 2 Diabetes, with the greatest effect resulting from a ketogenic diet paired
with exercise.

Methods:
The databases used when searching were the Directory of Open Access Journals and
PubMed for randomized control trials, non-randomized control trials, and prospective longitudinal
studies. Results were summarized in an evidence table found in the Appendix. Studies were not
limited by study type, age of study participants, gender, ethnicity, language, journal in which the
studies were published, or geographic location. One study utilized mouse models. Statistical analysis
was not performed.

Results:
Twelve trials were studied. Three trials studied the role of exercise and a ketogenic diet in
the treatment of Type 2 Diabetes. Five trials studied a ketogenic diet compared to another diet in
the treatment of Type 2 Diabetes. Two trials studied a ketogenic diet alone in the treatment of Type
2 Diabetes. One trial studied a ketogenic diet in those with pre-diabetes. One trial studied a ketogenic
diet in those with pre-diabetes and those diagnosed with Type 2 Diabetes. Every trial utilizing
a ketogenic diet showed marked improvement in glycemic control among participants in support
of the hypothesis. One study noted that while a ketogenic diet greatly improved glycemic control,
it created problems with lipid metabolism and the liver. When pairing a ketogenic diet with
exercise, hepatic steatosis was avoided. Eleven studies used adult participants, one used mouse
models. One study was a prospective longitudinal study, nine randomized control trials, one nonrandomized
control trial, and one observational cohort study.

Conclusions:
The studies provide encouraging results. A ketogenic diet consistently demonstrates
improved glycemic control in Type 2 Diabetics, and in those at risk of Type 2 Diabetes. However,
the studies are limited in their lack of exploration of the effects of a long-term ketogenic diet on the
liver, with only one study including this data. Randomized trials looking at the effect of a ketogenic
diet on the liver are needed. In addition, there were very few studies found when researching that
paired a ketogenic diet with exercise to study both the effect on glycemic control, as well as avoiding
potential hepatic steatosis.
Antihyperglycemic and Antidyslipidemic Effects of Artemisia arborescens
Aqueous Extract on Streptozotocin-induced Diabetic Rats
Authors: Eddouks Mohamed , Azzane Amine , Farid Omar 
Published: April 2022

Aims:
This study aimed to investigate the antidiabetic activity of Artemisia arborescens.

Background:
Artemisia arborescens is an aromatic, medicinal, and endemic plant mostly found in
the Mediterranean region. This plant is widely used as alternative medicine.

Objective:
The study was designed to examine the antihyperglycemic and antihyperlipidemic
activities of Artemisia arborescens aqueous extract (AEAA) in normal and streptozotocin (STZ)-
induced diabetic rats.

Methods:
The effect of AEAA (40 mg/kg and 80 mg/kg) on plasma glucose levels and plasma
lipid profile was investigated in normal and STZ-induced diabetic rats. The plasma glucose levels
were determined after a single (6 hours) and subchronic oral administration (7 days), and plasma
lipid profiles were evaluated after both acute and subchronic oral administration. Additionally, the
glycogen content in the liver, extensor digitorum longus (EDL), and soleus muscles was measured
using a standard method. Moreover, the aqueous extract was tested for its 1.1-diphenyl-2-
picrylhydrazyl (DPPH) radical-scavenging activity.

Results:
In diabetic rats, AEAA oral administration (40 mg/kg and 80 mg/kg) produced a significant
decrease in blood glucose levels after 7 days of oral administration (P<0.0001). Moreover, a
significant decrease in plasma triglyceride levels was reported on the last day of treatment by AEAA
(80 mg/kg) (P<0.05). Furthermore, a significant decrease in total cholesterol levels was observed
after 7 days of AEAA oral administration in diabetic rats (P<0.01). Moreover, a significant
increase in HDL-c concentration was noted after one week of AEAA (80 mg/kg) oral administration
(P<0.001). In addition, AEAA oral administration (80 mg/kg) significantly increased the glycogen
content in the liver and extensor digitorum longus (P<0.05). On the other hand, qualitative
and quantitative phytochemical screenings revealed the presence of various compounds, such as
polyphenols, flavonoids, and tannins.

Conclusion:
In summary, the study demonstrates that Artemisia arborescens oral administration
exhibited a significant antihyperglycemic effect on diabetic rats and revealed a significant amelioration
in lipid profile and glycogen content.
Satisfaction with Online-Teaching is Affected by COVID-Status for University Students
Authors: Reed Phil , Adjei-Mensah Priscilla , Truzoli Roberto 
Published: April 2022

Background:
Little is known about university students’ views regarding online teaching, one year after COVID restrictions.

Objective:
The current study examined predictors of satisfaction with online teaching and differences in views and predictors between those exposed or not exposed to COVID.

Methods:
340 university students (144 males; 194 females; 2 nonbinary) completed an online survey. The mean age was 25 years, with 132 undergraduates and 208 postgraduates. Students completed the Online Teaching Satisfaction Questionnaire, Center for Epidemiologic Studies Depression Scale, Becks Anxiety Inventory, the Locus of Control Scale, the General Self-Efficacy Scale, and the Brief-COPE Questionnaire.

Results:
Levels of satisfaction with online teaching were reasonable, with about 60% of students satisfied, but satisfaction was not especially high. Students appreciated the efforts of staff but did not find online materials stimulating. Students exposed to COVID needed more external support to be satisfied with their online experience.

Conclusion:
The results indicate that additional support measures will need to be put into place for COVID-exposed students if current online teaching delivery is to continue. Such information may help further developments in online learning, especially if this form of delivery needs to be extended for any length of time.
Health-Related Quality of Life Outcomes With Regular Yoga and Heartfulness Meditation Practice: Results From a Multinational, Cross-sectional Study
Authors: Thimmapuram Jayaram , Patel Kamlesh , Madhusudhan Divya K , Deshpande Snehal , Bouderlique Ekta , Nicolai Veronique , Rao Raghavendra 
Published: April 2022

Background
Although the benefits of yoga are well established across the world, there are limited studies exploring the long-term interrelation between yoga, meditation, and health. Specifically, there is limited research exploring the differences in health-related quality of life (HRQOL) among regular meditators and nonmeditators.

Objective
This study explored the differences in 7 domains of HRQOL (including quality of life, ability to adopt a healthy lifestyle, ability to relax, frequency of nervousness and stress, coping with day-to-day stress, workplace productivity, and staying healthy during the COVID-19 pandemic) among practitioners of yoga and meditation.

Methods
A cross-sectional, online survey was distributed to all members who participated in a 100-day yoga and meditation program, culminating in the International Day of Yoga event, organized by the Heartfulness Institute in partnership with the Central Council for Research in Yoga and Naturopathy, Ministry of Ayush, SVYASA Yoga University, and Patanjali Yoga Institute, India. The program consisted of daily virtual yoga, meditation, and speaker sessions. The data were analyzed by nonparametric Mann-Whitney U test and Kruskal-Wallis tests for continuous variables and chi-square test for categorical variables.

Results
A total of 3164 participants from 39 countries completed the survey. Mean age was 33.8 (SD 13.6) years. The majority of the participants were female (n=1643, 52%) and students (n=1312, 41.5%). Regular yoga and meditation practice was associated with a positive impact on all 7 domains of HRQOL (Mann-Whitney P<.05 and χ2P<.05). Notably, experienced Heartfulness (≥2 years) meditators reported better outcomes in all the domains of HRQOL as compared to those not currently practicing this form of meditation and participants with ≤1 year of Heartfulness meditation experience (P<.05).

Conclusions
This is one of the first cross-sectional studies to explore HRQOL outcomes among participants of a 100-day virtual yoga and meditation program. Overall, a yoga and meditation practice was found to be an effective tool for promoting HRQOL. Regular yoga and meditation practice was associated with factors promoting health and well-being, with long-term meditation practice associated with increased benefits.
ANALISIS PENGARUH INFLASI, PDRB, DAN UPAH MINIMUM TERHADAP PENYERAPAN TENAGA KERJA DI JAWA TIMUR
Authors: Warapsari Esthi Bhakti , Hidayat Wahyu , Boedirochminarni Arfida 
Published: April 2022

The population growth in Indonesia has been increasing steadily, so has the population growth in East Java Province. An increase in population will lead to an increase in the number of workers. The increasing number of workers will become a problem in the world of employment, if the number of workers available is not proportional to the demand for workers who are able to absorb. The results of this study indicate that the results of the study were negative and insignificant to the workforce in East Java Province with a coefficient of -0,000508 and a probability yield of 0.3650, while the GRDP had a positive and significant effect on labor in the East Java Province with a coefficient of 0,026689 and the probability result of 0.0468, and the minimum wage have a positive and significant effect on labor in the Province of East Java with a coefficient result of 0.132291 and a probability result of 0.0000.
ANALISIS PERBEDAAN RETURN SAHAM DAN VOLUME PERDAGANGAN SAHAM SAAT PANDEMI DIBANDING SEBELUM PANDEMI COVID-19 DI INDONESIA
Authors: Diansari Nila , Abdullah Muhammad Faisal , Syaifullah Yunan 
Published: April 2022

This study aims to see and analyze the differences in stock returns and trading volume of shares of transportation companies on the Indonesia Stock Exchange during the pandemic compared to before the Covid-19 pandemic in Indonesia. This study uses stock prices and stock trading volume on the Indonesia Stock Exchange from November 2019 to July 2020. The data analysis method used was the Kolmogorof Smirnov normality test and the Wilcoxon Signed Rank Test. The research results there is a significant difference in the stock returns of transportation companies during the Covid-19 pandemic compared to before the Covid-19 pandemic in Indonesia and there is a significant difference in the trading volume of shares of transportation companies during the Covid-19 pandemic compared to before the Covid-19 pandemic in Indonesia
ANALISIS PENDAPATAN HOME INDUSTRY PEUYEUM KETAN DI DESA TARIKOLOT KECAMATAN CIBEUREUM KABUPATEN KUNINGAN PROVINSI JAWA BARAT
Authors: Suryani Feby Dea , Boedirochminarni Arfida , Arifin Zainal 
Published: April 2022

This study aims to determine the income analysis of peuyeum sticky rice home industry in Tarikolot Village, Cibeureum District, Kuningan Regency, West Java Province. Observing the industrial development in an area such as Kuningan, there are still many developing industries such as the Peuyeum Ketan industry which is managed by small industries or household activity units that aim to cover their economic needs. Based on the research results, the total revenue in the Peuyeum home industry produces 60 to 200 buckets in one production process. The average total revenue at the peuyeum home industry was IDR 7,105,833 with an average production volume of 106 buckets, while the average profit at 30 peuyeum sticky rice home industries in Tarikolot Village was IDR 1,226,250 per one-time production. The total cost of production consists of fixed costs and variable costs with an average total cost of Rp 5,879,583. The peuyeum sticky rice industry is declared profitable or feasible to continue because the average value of R / C generated is 1.20> 1, meaning that the total income earned is greater than the total costs incurred.
Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil
Authors: Ramya S. , Loganathan T. , Chandran M. , Priyanka R. , Kavipriya K. , Grace Lydial Pushpalatha G. , Aruna Devaraj , Ramanathan L. , Jayakumararaj R. , Saluja Vikrant 
Published: April 2022

Seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma. C. cyminum have been used in traditional medicine to treat a variety of diseases. Literature presents ample evidence for biomedical activities of cumin which is attributed to its bioactive secondary metabolites - terpenes, phenols, and flavonoids. Besides, health effects of cumin seeds have been experimentally validated through phytochemical analysis depicting the presence of a wide array of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinone, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Pharmacological studies indicate that BASMs in seeds of C. cyminum exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. In the present study phytochemical screening, GCMS, FTIR profile of bioactive natural products from C. cyminum has been envisaged. Phytochemical screening revealed the presence of alkaloids, anthraquinones, carbohydrates, coumarins, flavonoids, glycosides, proteins, quinones, saponins, steroids, tannins and terpenoids. GC-MS analysis revealed the presence of 21 compounds, of which Cuminaldehyde was prominent. FTIR analysis showed the presence of a strong peak value for 15 compounds and medium peak value for 6 compounds. Many of the compounds in the list could be ADMET bioprospected for biomedical applications as natural drug leads.
Keywords: Cuminum cyminum; Cuminaldehyde; Bioactive Natural Products; GCMS; FTIR