bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subclinical Impairment of Left Ventricular Function assessed by Speckle Tracking in Type 2 Diabetic Obese and Non-Obese Patients
Authors: Abomandour Hala Gouda , Elnagar Ahmed Mahmoud , Aboleineen Mohamed Wafaie , Shehata Islam Elsayed 
Published: August 2022

Objectives:
Type 2 diabetes mellitus (DM) and obesity are an independent risk factor for cardiovascular diseases, so early prediction of LV dysfunction carries better prognosis. So our aim was to assess the subclinical LV dysfunction in type 2 diabetic obese and non-obese patients using two-dimensional speckle tracking echocardiography (2DSTE).

Materials and Methods:
We studied 93 patients, including two groups of 31 each with type 2 diabetes mellitus (T2DM), divided by body mass index (BMI), and 31 non-diabetic non-obese controls. All these subjects underwent two-dimensional Echo (2DE) imaging with analysis of conventional parameters of systolic and diastolic function, as well as speckle tracking echocardiography s (STE) analysis of LV global and regional longitudinal strain.

Results:
We reported significant inter-group differences in parameters of diastolic function, but no significant differences in ejection fraction or fractional shortening. Nevertheless, we found significant differences in strain, which we interpreted as evidence of subclinical systolic dysfunction.

Conclusion:
2DSTE is better than basic echocardiographic measurements in assessment of subclinical LV dysfunction in type 2 diabetic obese and non-obese patients which can be used to predict cardiomyopathic changes in the earlier course of type 2 DM and start earlier treatment with better prognosis.
Critical Analysis of Laboratory Requisition Forms Received in a Cytopathology Laboratory of a Tertiary Care Centre
Authors: Sehgal Shivali , Jetley Sujata , Jairajpuri Zeeba S. , Khan Sabina 
Published: August 2022

Background:
A laboratory requisition form (LRF) is the main communication link between the laboratories and the clinicians. In a cytopathology laboratory, incomplete forms with inadequate information significantly impact the quality of the results and waste precious time of the lab.

Aims:
The aim of this study was to audit the LRFs for adequacy of demographic and clinical data and to analyze the reasons for the same.

Settings and Design:
A retrospective study was conducted in the cytopathology laboratory of a tertiary care center.

Materials and Methods:
All the original LRFs received for Pap smears and FNACs of 1-month duration were retrieved. The forms were scrutinized for the presence of specific parameters which were classified as patient information, clinician information and clinical information. In addition to the completeness of the form, clarity of the data was also noted.

Statistical Analysis:
The data were entered on excel worksheets and percentage of Pap smear and FNAC forms lacking information of various parameters was calculated.

Results:
A total of 431 LRFs were received in the month of January 2020. These included 274 Pap smear LRFs and 157 FNAC LRFs. Patient information was mentioned in predominantly all the forms, however, clinician and clinical information, which is indispensible for reporting, was missing in a significant proportion of the Pap smear and fine needle aspiration cytology (FNAC) forms.

Conclusions:
Receiving inadequately filled LRFs has been an age-old problem in all medical laboratories. Audit of inadequacy of LRFs helped in assessing the prevailing practices in the hospital and gave an insight into the quality of information available to the cytologists for reporting. Many clinicians withhold information out of ignorance about its importance or due to lack of time to fill up the details on the LRF. Also, filling out a LRF is a task usually delegated to the junior doctor in the OPD and the significance of filling the LRF correctly and comprehensively is often not emphasized upon adequately by the senior clinicians. This audit helped us taking preventive action by giving feedback to the clinicians and emphasizing to them the importance of clinical data on the LRF and in improvising the LRF using a more objective and user-friendly format.
The Relationship between Immature Granulocyte Count and Mortality in Ards Due to Covid-19
Authors: Alay G H , Tatlisuluoglu D , Bulut K , Fikri B I , Oztas A , Turan G 
Published: August 2022

Background:
Acute phase reactants and inflammation biomarkers such as ferritin, procalcitonin, C-reactive protein (CRP), and complete blood count parameters (White blood cell, platelet count) are usually used to evaluate and monitor the disease severity and treatment response of systemic inflammatory diseases. In addition to these parameters, Immature granulocytes (IG) that increase during systemic infection, hematological malignancy, and drug treatments (such as chemotherapy and glucocorticoids) are important parameters for evaluating systemic inflammation. The sensitivity and specificity of IG are as high as the abovementioned inflammatory biomarkers for monitoring disease severity and treatment response.

Aim:
The aim of the study is to evaluate the relationship between IG count and the need for mechanical ventilation and mortality in patients hospitalized in the intensive care unit (ICU) due to coronavirus disease 2019 (COVID-19).

Patients and Methods:
The medical records of the 401 patients who were followed up in the ICU due to COVID-19-related acute respiratory distress syndrome between October 2020 and February 2021 were retrospectively reviewed. On the day of admission to the ICU complete blood count (CBC), arterial blood gas analysis, coagulation parameters (fibrinogen, D-dimer) are recorded. CRP, procalcitonin, and ferritin levels are also recorded at the day of admission. During the follow-up period, the survival status and mechanical ventilation status of the patients were recorded and the relation between IG count and these parameters was evaluated.

Results:
The mean IG at the admission was 0.2 ± 0.4 109/L. The IG level of the intubated patients at the time of intubation was 0.3 ± 0.5 109/L. There was a significant positive correlation between mortality and IG levels at admission and at the time of intubation (IG admission; P = 0.001, r = 0.347 and IG at intubation; P = 0.001, r = 0.228).

Conclusion:
IG levels in CBC data could be a potential practical biomarker. This issue requires further research and the development of therapies targeting IG cells is needed.
In Vitro Study of the Effect of High Temperature on Erythrocytes in Sickle Cell Trait
Authors: Aljohani Maher M 
Published: August 2022

Background:
Although, sickle cell trait (SCT) was considered a benign condition with most patients being asymptomatic, however, there is an impressive increase in the number of sudden deaths in the military recruits and athletes, which has led to SCT as a rapidly emerging medical issue. Genetic factors have been extensively investigated in the etiopathogenesis of SCT but, environmental factors have not been studied in depth.

Aims:
The main aim of this study was to investigate the effect of high temperature on the red blood cells (RBCs) in those with SCT and compare this to a control group lacking SCT.

Patients and Methods:
Heat stress to RBCs was induced by in vitro incubation of freshly drawn blood at high temperatures (45°C for 35 min). Additional information such as hemoglobin (Hb) level, RBC count, mean corpuscular volume (MCV), and hemoglobin S level was obtained from the medical record of the case and control groups. Data were entered in Statistical Package for Social Sciences version 22.0 (IBM Corp, Armonk, NY, United States) and analyzed to examine the research hypothesis.

Results:
A total of 17 blood samples from SCT (HbAS subjects) labeled as cases and 16 samples from controls (HbAA subjects) were included in this study. The results of this study showed no significant change in sickled erythrocytes in SCT in response to in vitro heat stress.

Conclusion:
This study's findings appear to suggest that hyperthermia could be excluded as one of the major factors inducing sickling complications during exhausting exercise. Long-term studies in the future are recommended in this area, particularly to assess the effect of high temperature and sudden death in SCT.
Intravenous Immunoglobulin in Hemolytic Disease of the Newborn
Authors: Vardar G , Okan M A , Karadag N , Topcuoglu S , Ozalkaya E , Karatepe H O , Karatekin G 
Published: August 2022

Background:
Alloimmune hemolytic disease of the newborn (AIHDN) results in hemolysis, anemia, hyperbilirubinemia with the potential for brain damage. Intravenous immunoglobulin (IVIG) has been investigated as an alternative low-risk procedure for the treatment of AIHDN in addition to traditional treatment methods such as phototherapy and exchange transfusion (ET).

Aim:
To evaluate the effectiveness of IVIG therapy in decreasing ET needs based on risk factors and clinical outcomes.

Materials and Methods:
Charts of neonates born >30 weeks of gestation who underwent phototherapy and were administered IVIG therapy due to AIHDN between January 2013 and July 2018 were retrospectively reviewed.

Results:
Sixty-three neonates were included in our study. Forty-three of them (68.3) % were full-term infants. ABO incompatibility (n = 33, 52.4%) was the major cause of AIHDN (n = 63). Additional risk factors for jaundice were found to coexist in 95.2% (n = 60) of the infants. Fifteen infants (23.8%) required ET, mostly due to Rh incompatibility (n = 11, 73.3%). Mortality was observed in 3.2% (n = 2) of the patients, 1.6% (n = 1) of whom were related to ET. Serum albumin value was found to be negatively correlated with the requirement for ET (r = 0.713, P < 0.001), whereas serum bilirubin albumin ratio was positively correlated (r = 0.489, _P < 0.001). Nine (14.3%) infants needed a simple transfusion during the hospitalization period, whereas five (7.9%) infants had readmission for simple transfusion after discharge. Apnea was the only complication seen in one (1.6%) patient.

Conclusion:
IVIG treatment should be considered due to its relative benefits when compared to exchange transfusion. In addition to its safety, it is a less complicated treatment modality with low side effect rates. It may be justified for elective use in neonates suffering from AIHDN, who will require ET with a risk of mortality by decreasing the peak of total serum bilirubin levels.
The Effect of Arthroscopic Rotator Cuff Repair on Sleep in Degenerative Full-Thickness Tears
Authors: Gulcu A 
Published: August 2022

Aims and Background:
Shoulder pathologies are frequently linked to sleep disturbances. The aim of this study is to investigate the effect on sleep disorders in patients with arthroscopic rotator cuff repair.

Materials and Methods:
Thirty-three patients who underwent arthroscopic rotator cuff repair due to a full-thickness rotator cuff tear were prospectively analyzed. The Pittsburgh Sleep Quality Index (PSQI), the American Shoulder and Elbow Surgeons Shoulder Score (ASES), visual analog scale (VAS), and Constant and Murley shoulder scores before surgery and at 6 months postoperatively. Preoperative clinical and radiological parameters of the patients were also evaluated.

Results:
The study analyzed 33 patients with a median age of 59.79 ± 9.0 years. There was a significant difference preoperatively versus postoperatively in terms of all PSQI global scores and subdivisions (P < 0.001). A statistically significant improvement was determined by the simple shoulder test, the Constant and Murley shoulder scores, and VAS (P < 0.001).

Conclusion:
Sleep disturbance is common in patients with symptomatic rotator cuff tear, and sleep disturbance can resolve after arthroscopic rotator cuff repair.
Ureteropelvic Junction Obstructions
Authors: Ozaydin S , Celebi S 
Published: August 2022

Background:
Ureteropelvic junction obstructions (UPJOs) occur more frequently on the left than on the right side. Among patients diagnosed during the neonatal period, those with left-side UPJO have a more severe course than those with right-side UPJO.

Aim:
This study examined clinical advances in the surgical management of right and left symptomatic UPJOs preoperatively and postoperatively, based on a retrospective analysis of cases.

Patients and Methods:
In this retrospective clinical trial, 650 patients were evaluated at the time of diagnosis and at surgery.

Results:
Left-side UPJO was diagnosed in 66.1% of patients (P = 0.017). The median age of the patients at surgery for left- and right-side UPJO was 1.5 and 4.2 years, respectively (P = 0.001). At the preoperative evaluation, the ratio of parenchymal thickness (RPT) on the UPJO side versus the contralateral side was 0.55 ± 0.3 and 0.7 ± 0.3 for patients with left-side and right-side UPJO, respectively (P = 0.029). RPT during the first postoperative year was 0.83 ± 0.2 for patients treated on the left side and 0.9 ± 0.3 for those treated on the right side (P = 0.25). The respective values at 3 years postoperatively were 0.8 ± 0.3 and 0.9 ± 0.2 (P = 0.09). The preoperative kidney function value in the left-side group was 42.5 ± 13.4, which declined to 39.52 ± 15.8 at the 3-year follow-up examination. In the right-side group, preoperative kidney function was 38.8 ± 16.1, which increased to 40.2 ± 13.2 at 3 years postoperatively. Both the decline and improvement were significant (both P = 0.006).

Conclusions:
Those with left-side UPJO had a more severe course than those with right-side UPJO.
Effets de la durée de conservation et du prétraitement sur les paramètres de germination des graines du corossolier (Annona muricata L.) au Cameroun
Authors: Ndjoumoui Charles Amele , Augustin Mewounko , Christian Misse Alain , Cedric Chimi Djomo 
Published: August 2022

Le corossolier (Annona muricata L.) fait partir des espèces très sollicitées du point de vue socioéconomiques et thérapeutiques. Les difficultés de régénération naturelles que connaît cette espèce réduisent sa distribution géographique impactant ainsi sa production au niveau du Cameroun. Face à cette contrainte, une étude axée sur le test de germination du corossolier a été effectuée au sein de la Station polyvalente Agricole de Bertoua. L’approche méthodologique inclue l’application de 4 traitements à 4 lots de semences constitués suivant la durée de conservation. Les résultats obtenus ont montré un taux de germination au-dessus de 80% pour la quasi-totalité des traitements appliqués aux différents lots, excepté le témoin qui a eu un taux de germination de 67%. Le délai de germination débute le 25ème jour et va jusqu’au 31ème jour pour une durée de germination variant de 2 à 6 jours. Les taux de germination ont régressés avec la durée de conservation et les graines conservées pendant 90 jours ont eu le plus faible taux de germination. Les traitements scarification et trempage des graines ont améliorées significativement le taux de germination des graines de corossolier et la conservation des semences au-delà de 90 jours affecte leur qualité germinative. Cette étude est une contribution sur les connaissances en rapport avec la durée de conservation sur la germination des graines de corossolier.
The Rise of the White Serbia in the Light of the Merovingians’ Thuringia Policy
Authors: Vatseba R. 
Published: August 2022

The study offers an analytical overview of the international relations in the territory of the Middle Elbe basin from the 530s until the early 8th century, specifically concerned with the policy of the Merovingian kings towards the former Thuringian kingdom lands and the issue of the rise of White Serbia. The author considers Frankish policy as an influencing factor in slavisation of the discussed region while examining the impact of a wider spectrum of possible factors, in particular, the changes in ecology and the Avar presence in the Middle Danube region. The chronology of the Serbian settlers’ arrival into the Middle Elbe valley as well as their political & legal status in that land are specified. The author discusses the issue of the White Serbs’ initial foreign policy orientation and investigates the causes, direction, time & consequences of its change. The main research content is complemented by the excurses on the climatic crisis of the Late Antique Little Ice Age and chosen aspects of the Avars’ & the White Serbs’ early ethnic history. The author develops W. Fritze’s hypothesis of the Merovingians’ active involvement and support of the Serbian immigration into the Middle Elbe and Saale region together with an idea of anti-Avar direction of this measure. Whereas, the results of the study have rejected the assumptions, that the Elbe Germans abandonment of the area to the east of the Elbe and Saale at the end of the third quarter of the 6th century was caused by the Frankish-Avar agreement or Slavic pressure. The author concludes that the first group of the Serbian settlers arrived to the Middle Elbe and Saale from the North-Western Bohemia during the Austrasian king Theudebert ІІ’s reign, probably, at the invitation of the famous Brunhilda, receiving the lands in Thuringia’s border zone as the Frankish foederati. The interconnection between the initial successes of the Merovingians’ Serbian policy in the east of Thuringia during the first decades of the 7th century and the settlement of the Croats & Serbs in the Balkans by the emperor Heraclius is revealed. It has been demonstrated that further expansion of the White Serbia’s territory from the 630s was of spontaneous nature and took place under the circumstances of the collapsed Merovingian control over Thuringia.
Características de la infección de Helicobacter pylori en un hospital privado de Lima, experiencia del 2019 y revisión de la literatura.
Authors: Yoza Yoshidaira Max , Carrasco Navarro Roberto Maximiliano , Li Salvatierra Bruno , Bustios Sánchez Carla , Contardo Zambrano Carlos , Palacios Salas Fernando , Miyagui Maeda Juan , Niebuhr Kakiuchi Juan , Canales Sevilla Olivia , Monge Zapata Victor 
Published: August 2022

Las enfermedades digestivas representan la cuarta causa de atención ambulatoria en los centros sanitarios peruanos, siendo la gastritis y las úlceras pépticas las más comunes. El presente es un estudio retrospectivo, de corte transversal , de tipo descriptivo, de análisis secundario de datos de historias clínicas, para evaluar la prevalencia de Helicobacter pylori en pacientes sometidos a endoscopia digestiva alta durante el año 2019 en la Clínica Delgado , Lima , Perú. Asociación entre el sexo masculino ( PRa 1.27 , IC95% 1.10 - 1.48 , p <0.001) , categorías de la edad y resultado de endoscopia digestiva alta (PRa 2.53 , IC95% 2.16 - 2.97 , p<0.001) fueron reportados. Se recomienda , a partir de estos hallazgos , determinar otras causas de gastritis, especialmente en las mujeres jóvenes con gastritis crónica profunda. Además, presentamos una revisión de la literatura científica del Perú sobre los factores asociados a la positividad de Helicobacter Pylori en los resultados de la endoscopia digestiva superior.
Adaptasi Bahasa Skala Niat Mencari Bantuan Kesehatan Mental
Authors: Ratih Dewi Woro , Maba Aprezo Pardodi , Hernisawati Hernisawati 
Published: August 2022

Skala niat mencari bantuan kesehatan mental masih jarang mendapat perhatian dari para peneliti di Indonesia. Penulis meyakini bahwa niat mencari bantuan ini perlu diukur untuk mengetahui keadaan faktual kemungkinan seseorang menggunakan layanan kesehatan mental. Oleh karena itu, dalam artikel ini, penulis melakukan adaptasi instrumen niat mencari bantuan dari Bahasa Inggris ke Bahasa Indonesia. Penulis melakukan beberapa tahap dalam adaptasi 1) meminta izin kepada pemilik instrumen, 2) melakukan penerjemahan instrumen ke Bahasa Indonesia dilakukan oleh beberapa orang yang memiliki kompetensi, 3) melakukan ekuivalensi hasil terjemahan, 4) melakukan back-translate ke Bahasa Inggris, 5) melakukan validasi (Ahli Bahasa dan Pengguna), dan 6) melakukan analisis menggunakan V-Aiken. Hasil penelitian menunjukkan bahwa adaptasi bahasa instrumen niat mencari bantuan masuk dalam kategori valid dengan nilai V-Aiken=0,80. Dengan demikian, instrumen niat mencari bantuan yang diadaptasi sudah dapat diujikan lebih lanjut untuk melihat validitas internal dan reliabilitasnya.
Columnar and surface urban aerosol in the Moscow megacity according to measurements and simulations with the COSMO-ART model
Authors: Chubarova Natalia E. , Vogel Heike , Androsova Elizaveta E. , Kirsanov Alexander A. , Popovicheva Olga B. , Vogel Bernhard , Rivin Gdaliy S. 
Published: August 2022

Abstract. Urban aerosol pollution was analyzed over the Moscow
megacity region using the COSMO-ART (COSMO – COnsortium for Small-scale MOdelling, ART – Aerosols and Reactive Trace gases) online coupled
mesoscale model system and intensive measurement campaigns at the Moscow
State University Meteorological Observatory (MSU MO, 55.707∘ N,
37.522∘ E) during the April–May period in 2018 and 2019. We analyzed mass concentrations of particulate matter with diameters smaller than 10 µm (PM10), black carbon (BC) and aerosol gas precursors (NOx, SO2, CHx) as well as columnar aerosol parameters for fine and coarse modes
together with different meteorological parameters, including an index characterizing the intensity of particle dispersion (IPD). Both model and experimental datasets have shown a statistically significant linear
correlation of BC with NO2 and PM10 mass concentrations, which
indicates mostly common sources of emissions of these substances. There was
a pronounced increase in the BC/PM10 ratio from 0.7 % to 5.9 %, with the decrease in the IPD index related to the amplification of the atmospheric
stratification. We also found an inverse dependence between the BC/PM10
ratio and columnar single-scattering albedo (SSA) for the intense air mixing conditions. This dependence together with the obtained negative correlation
between wind speed and BC/PM10 may serve as an indicator of changes in the absorbing properties of the atmosphere due to meteorological factors. On
average, the relatively low BC / PM10 ratio (for urban regions) of 4.7 % is the cause of the observed relatively high SSA = 0.94 in Moscow. Using long-term
parallel aerosol optical depth (AOD) measurements over the 2006–2020 period
at the MSU MO and under upwind clean background conditions at Zvenigorod Scientific Station (ZSS) of the IAP RAS (55.7∘ N, 36.8∘ E), we estimated the
urban component of AOD (AODurb) and some other parameters as the
differences at these sites. The annual mean AODurb at 550 nm was about
0.021 with more than 85 % of the fine aerosol mode. The comparisons between AODurb obtained from the model and measurements during this experiment have
revealed a similar level of aerosol pollution of about AODurb=0.015–0.019, which comprised 15 %–19 % of the total AOD at 550 nm. The urban
component of PM10 (PM10urb) was about 16 µg m−3
according to the measurements and 6 µg m−3 according to the
COSMO-ART simulations. We obtained a pronounced diurnal cycle of
PM10urb and urban BC (BCurb) as well as their strong correlation with the IPDs. With the IPD index change from 3 to 1 at night, there was
about a 4 times increase in PM10urb (up to 30–40 µg m−3) and a 3 times increase in BCurb (up to 3–3.5 µg m−3). At the same time, no pronounced daily cycle was found for the columnar urban aerosol
component (AODurb), although there was a slight increase in model
AODurb at night.