bluuebunny/crossref_metadata_2025_split huggingface dataset:
Essential Oil Composition and Antibacterial Activity of Juniperus oxycedrus ssp. macrocarpa (S. et Sm.) BalI. Growing in Oum El Bouaghi (Semi- arid area), Algeria
Authors: Basa Nora , Djebaili Hind , Mokrani Meryem , Senoussi Mohamed Mourad , Boulehbal Souad , Zellagui Amar 
Published: March 2022

Leaf essential oils of Juniperus oxycedrus (Cupressaceae) wild grown in the region of Oum El Bouaghi (semi- arid area) in Algeria have been analysed by gas chromatography/mass spectrometry (GC/MS). Fifty seven compounds were identified in the leave oils. The leaf oils were mainly composed of 5-Tetradecen-1-ol, acetate, (Z)-(12.9%) ç-Muurolene (9.1%), α-Cadinol (5.1%) (ñ)-Cadinene (3.9 %) and some other compounds which were only present in minor amounts.
Aims: This study aimed to extracted, identification of essential oils of Leaves of J. oxycedrus L. ssp. macrocarpa (S. et Sm.) BalI. growing in Oum El Bouaghi (semi- arid area), Algeria and evaluation of their antibacterial capacity.
Results: The GC/MS analysis of the Leaves of J. oxycedrus L. (yielded 0, 36 %) permitted the identiﬁcation of fifty seven components. The composition and percentage of the compounds are listed by their order of retention times. The main constituents of the essential oil were composed of 5-Tetradecen-1-ol, acetate, (Z) - (12.9%) ç-Murolene (9.1%), α-Cadinol (5.1%) (ñ)-Cadinene (3.9 %) and some other compounds were only present in minor amounts. The antimicrobial activity of the essential oils were evaluated by the disc diffusion method and tested against Gram-negative Escherichia coli, Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus bacteria. Results showed that Staphylococcus aureus was the highly resistant to the essential oil.
Conclusion: The results of analysis of the components Leaves of Juniperus oxycedrus ssp. macrocarpa (S. et Sm.) BalI. growing in Oum El Bouaghi (semi- arid area), Algeria, permitted the identiﬁcation of fifty seven components. The essential oil showed that the essential oil of juniperus oxycedrus has the potential to act as an antibacterial agent.
Regulating the Electrolyte Solvation Structure Enables Ultralong Lifespan Vanadium‐Based Cathodes with Excellent Low‐Temperature Performance
Authors: Liu Dao‐Sheng , Zhang Yufei , Liu Sucheng , Wei Licheng , You Shunzhang , Chen Dong , Ye Minghui , Yang Yang , Rui Xianhong , Qin Yanlin , Li Cheng Chao 
Published: March 2022

AbstractAqueous Zn||vanadium oxide batteries (ZVBs) have recently received considerable attention owing to their high capacity, safety, environmental friendliness, and cost effectiveness. However, the limited cycling stability caused by the irreversible dissolution in traditional aqueous electrolytes still restricts their further application. Herein, a novel 3 m Zn(CF3SO3)2 electrolyte with a mixture solvent of propylene carbonate (PC) and H2O is adopted for aqueous vanadium‐based zinc‐ion batteries. With the manipulation of the electrolyte solvation structure, the optimized P20 (20% PC in volume ratio) electrolyte enables super‐stable cycling performance with high‐capacity retention of 99.5%/97% after 100/1000 cycles at 0.1/5 A g−1 at ambient environment in the Zn||NaV3O8·1.5H2O batteries. Systematical electrochemical testing and characterizations illustrate the addition of PC effectively reduces the active water molecule in Zn2+‐solvent cations and H+ in the electrolyte, thereby suppressing the cathode dissolution caused by the inserted H+ and co‐inserted H2O during the discharge/charge process. Impressively, the PC addition also enabled the Zn||NaV3O8·1.5H2O batteries present high specific capacity of 183/168 mAh g‐1 and high‐capacity retention of 100%/100% over 300/400 cycles at 0.1/0.2 A g‐1 at −40 °C, thus efficiently broadening the practical application for ZVB. This research may provide a promising strategy for designing high‐performance electrolytes for aqueous vanadium‐based batteries.
Sensitive Activatable Nanoprobes for Real‐Time Ratiometric Magnetic Resonance Imaging of Reactive Oxygen Species and Ameliorating Inflammation In Vivo
Authors: Li Xilan , Liu Yun , Qi Xiaowei , Xiao Shilin , Xu Zhongsheng , Yuan Zhixian , Liu Qi , Li Haisheng , Ma Siyuan , Liu Tengfei , Huang Yong , Zhang Xiaorong , Zhang Xiao , Mao Zhengwei , Luo Gaoxing , Deng Jun 
Published: March 2022

AbstractImaging‐guided real‐time monitoring of the treatment process of inflammatory diseases is important for the timely adjustment of treatment planning to lower unnecessary side effects and improve treatment outcomes. However, it is difficult to reflect the dynamic changes of inflammation in vivo with enough tissue penetration depth. Here a novel nanotheranostic agent (denominated TMSN@PM) with platelet membrane (PM)‐coated, tempol‐grafted, manganese‐doped, mesoporous silica nanoparticles is developed. The PM endows the TMSN@PM with the ability to target inflammation sites, which are verified by fluorescence imaging with Cyanine5 carboxylic acid (Cy5)‐labeled TMSN@PM. Under the inflammatory environment (mild acidity and excess reactive oxygen species (ROS)), TMSN@PM can scavenge the excess ROS, thereby alleviating inflammation, degrade, and release manganese ions for enhanced magnetic resonance imaging (MRI). The relaxation changes (ΔR1) are almost linearly correlated with the concentration of H2O2, which can reflect the degree of inflammation. This method offers a non‐invasive imaging‐based strategy for early prediction of the therapeutic outcomes in inflammatory therapy, which may contribute to precision medicine in terms of prognostic stratification and therapeutic planning in future.
Magnetoelectric Effect in Hydrogen Harvesting: Magnetic Field as a Trigger of Catalytic Reactions
Authors: Kim Donghoon , Efe Ipek , Torlakcik Harun , Terzopoulou Anastasia , Veciana Andrea , Siringil Erdem , Mushtaq Fajer , Franco Carlos , von Arx Denis , Sevim Semih , Puigmartí‐Luis Josep , Nelson Bradley , Spaldin Nicola A. , Gattinoni Chiara , Chen Xiang‐Zhong , Pané Salvador 
Published: March 2022

AbstractMagnetic fields have been regarded as an additional stimulus for electro‐ and photocatalytic reactions, but not as a direct trigger for catalytic processes. Multiferroic/magnetoelectric materials, whose electrical polarization and surface charges can be magnetically altered, are especially suitable for triggering and control of catalytic reactions solely with magnetic fields. Here, it is demonstrated that magnetic fields can be employed as an independent input energy source for hydrogen harvesting by means of the magnetoelectric effect. Composite multiferroic CoFe2O4–BiFeO3 core–shell nanoparticles act as catalysts for the hydrogen evolution reaction (HER), which is triggered when an alternating magnetic field is applied to an aqueous dispersion of the magnetoelectric nanocatalysts. Based on density functional calculations, it is proposed that the hydrogen evolution is driven by changes in the ferroelectric polarization direction of BiFeO3 caused by the magnetoelectric coupling. It is believed that the findings will open new avenues toward magnetically induced renewable energy harvesting.
More than Carbazole Derivatives Activate Room Temperature Ultralong Organic Phosphorescence of Benzoindole Derivatives
Authors: Qian Chen , Ma Zhimin , Fu Xiaohua , Zhang Xue , Li Zewei , Jin Huiwen , Chen Mingxing , Jiang Hong , Jia Xinru , Ma Zhiyong 
Published: March 2022

AbstractThe mechanism of carbazole (Cz)‐based phosphors is still unclear since its isomer (1H‐benzo[f]indole, Bd) is discovered in 2020. Herein, the successful synthesis of four Cz/Bd derivatives is reported, named as 2CzBr, CzBdBr, 2BdBr, and 3Bd, and the general mechanism for their ultralong organic phosphorescence (UOP) is provided. Bd and its derivatives give double groups of phosphorescence, including the short‐wavelength phosphorescence with a short lifetime and the ultralong phosphorescence at long wavelengths, assigned to their neutral molecules and radical cations, respectively. Interestingly, the doped poly(methyl methacrylate) (PMMA) films of CzBdBr and 2BdBr show photo‐activated ultralong phosphorescence at room temperature. The activation of Bd derivatives ‘UOP involves three factors: 1) well dispersion in the matrix with limited amount, 2) generation of their radical cations and 3) the matrix‐mediated stabilization of radical cations. The function of Cz derivatives to activate the Bd derivatives’ UOP could be replaced by photo‐activation or using other matrixes. Significantly, the application of the doped PMMA films is practiced and gives an exciting result that the high‐resolution QR code could be reversibly printed and erased on the film. This research has expanded the understanding in the field of organic phosphorescence and it may pave a new way for its development.
Off‐Cycle Catalyst Cooperativity in Amine/Transition Metal Combined Catalysis: Bicyclo[3.2.0]heptanes as Key Species in Co‐Catalytic Enantioselective Carbocyclizations
Authors: Afewerki Samson , Ma Guangning , Deiana Luca , Wu Hongli , Huang Genping , Córdova Armando 
Published: March 2022

AbstractThe existence of off‐cycle catalyst cooperativity in amine/metal combined catalysis is disclosed. The experimental and density functional theory study of the amine/metal co‐catalyzed enantioselective Michael/carbocyclization cascade reaction between allenes and α,β‐unsaturated aldehydes reveals that the dual catalysts can perform off‐cycle cooperativity that gives access to stable bicyclo[3.2.0]heptane species that limits the carbocycle product formation. Insight into this mode of co‐catalyst cooperativity sheds new light on the chiral amine/metal co‐catalyzed reactions of to date and gives deeper understanding for improved future design of this type of enantioselective reactions.magnified image
Interfacial Modification by Low‐Temperature Anchoring Surface Uncoordinated Pb for Efficient FAPbI3 Perovskite Solar Cells
Authors: Tang Jin , Liu Le , Yu Zhibin , Du Jiajia , Cai Xu , Zhang Mei , Zhao Min , Bai Ling , Gai Zhigang , Cui Shuang , Li Xiaofang , Jiu Tonggang 
Published: March 2022

AbstractSurface modification of perovskite film plays an important role on the suppression of surface defects for the fabrication of high‐efficiency perovskite solar cells. Here, 1H‐Pyrazole‐1‐carboxamidine hydrochloride (PAH) as a multifunctional heterocyclic ring‐based organic ionic salt to modify the surface of FAPbI3 film at room temperature is demonstrated. XPS and FTIR results demonstrate that the sufficient active sites contribute to the interaction between PAH and surface Pb ions of the perovskite, which is helpful to reduce the trap states on the perovskite film so as to increase the device performance. The modification is beneficial to the suppression of charge recombination and the promotion of charge transfer by anchoring to the uncoordinated Pb ions on the surface both at the interface of stacking layers and the grain boundary. With prolonged charge carrier lifetime and elevated charge transfer, an improved PCE of 20.9% is obtained for the as‐prepared planar devices based on FAPbI3, along with simultaneous enhancement of open circuit voltage and fill factor. The findings further pave the way for utilizing novel organic salts for surface modification, which presents a promising route for the fabrication of efficient photovoltaic devices.
Unveiling the Synergistic Effect of Ferroelectric Polarization and Domain Configuration for Reversible Zinc Metal Anodes
Authors: Chen Tao , Huang Fei , Wang Yinan , Yang Yi , Tian Hao , Xue Jun Min 
Published: March 2022

AbstractThe tendency of zinc (Zn) anodes to form uncontrolled Zn electrodeposits and the occurrence of side‐reactions at Zn‐electrolyte interfaces are a fundamental barrier hampering broad applications of aqueous rechargeable Zn‐based batteries. Herein, a ferroelectric domain‐mediated strategy is proposed to manipulate the Zn plating behavior and achieve controllable Zn growth orientation by coating Zn foil with a ferroelectric tetragonal KTN (t‐KTN) layer. The ferroelectric domain of t‐KTN single crystals exhibits periodic distribution of upward and downward polarizations, corresponding to alternating positively and negatively charged surfaces. The charged ferroelectric surfaces can manipulate the transfer kinetics of Zn ions and the concentration distribution of anions via the interplay between ferroelectric dipoles and adsorbed ions. With the synergistic effect of the ferroelectric polarization and domain configurations, the well‐aligned interlamellar arrays composed of electrodeposited Zn are formed in the initial deposition process, which enable selective deposition within interlamellar arrays and eliminate the dendrite growth during the following plating process. As a result, the t‐KTN layer‐modified Zn anode enables reversible Zn plating/stripping with low voltage hysteresis for over 1200 h at 1 mA cm−2 in symmetric cells, and the assembled full cell exhibits a significantly enhanced cycling stability of over 5500 cycles at 5 A g−1.
Sex‐specific differences in reproductive life‐history traits of the moss Weissia jamaicensis
Authors: Santos Wagner L. , Pôrto Katia C. , Pinheiro Fabio 
Published: March 2022

AbstractPremiseWe investigated sex‐specific differences in the life‐history traits of a metapopulation of the dioicous moss Weissia jamaicensis. Field observations revealed high rates of fertilization, which is uncommon for most dioicous bryophytes. We raised four hypotheses associated with the way the reproductive traits are related to the fertilization rate in this metapopulation.MethodsWe sampled 10 patches of the metapopulation and quantified sexual expression, sex ratio, reproductive success, and reproductive allocation. The ramets were classified as male, non‐sporophytic female, sporophytic female, or non‐sex‐expressing. Thirty ramets from each of the categories expressing sex were placed for regeneration to test the effect of reproductive allocation on this trait.ResultsWe found greater expression of the female function in all patches, implying a female bias in the metapopulation. The number of male ramets was variable in each patch and did not affect reproductive success. At the prezygotic level, the allocation of resources to the male function was higher. However, the large allocation of resources to sporophyte development in sporophytic females, which exceeded allocations at prezygotic levels, was related to the higher mortality rate of these ramets, suggesting reproductive cost.ConclusionsThe prezygotic ramets that allocated the greatest amount of resources to reproduction expressed sex less frequently, biasing the sex ratio toward the sex that allocated the least amount of resources to reproduction. Overall, the ramets that allocated the greatest amount of resources to reproduction had the lowest regeneration rate, suggesting reproductive cost.
Royal‐jelly‐based apitherapy can attenuate damages to male reproductive parameter following nicotine administration
Authors: Nazar‐Zadeh Mahsa , Jalili Cyrus , Nikgoftar Fathi Amene , Ghanbari Ali , Bakhtiari Mitra 
Published: March 2022

AbstractBackgroundNicotine administration can generate severe oxidative stress and lipid peroxidation. Royal jelly, with its antioxidant properties, acts as a scavenger of reactive oxygen species. This study describes the apitherapy effects of royal jelly on testicular damage following nicotine administration.MethodsForty‐eight male BALB/c mice were divided into 8 groups (n = 6): saline, 3 different doses of royal jelly (100, 150, and 200 mg/kg body weight (BW) per day), nicotine (1.5 mg/kg), and 3 different groups of Nic + Roy (1.5 mg/kg of Nic + 100, 150, and 200 mg/kg BW per day of royal jelly). Nicotine was administrated intraperitoneally, and royal jelly was prescribed orally for 10 consecutive days. Serum levels of hormones (testosterone, luteinizing hormone, and follicle‐stimulating hormone), total antioxidant capacity, nitric oxide (NO) status, malondialdehyde levels, sperm DNA fragmentation, sperm parameters, histopathological changes (H&E staining), immunohistochemistry against apoptotic proteins, and gene expression of Bcl‐2, p53, Caspase‐3, and Nrf2 (real‐time PCR) were assessed to evaluate the molecular and histological changes.ResultsHormone levels, sperm parameters, and status of antioxidants were decreased significantly (p < .05) following nicotine administration. Moreover, royal jelly treatment normalized hormonal and antioxidant characteristics, decreased apoptotic gene expression, increased Nfr2 gene expression, and restored histopathological alteration to the physiological status significantly (p < .05).ConclusionRoyal jelly upregulates the antioxidant status, inhibits the mitochondrial‐dependent apoptosis pathway, and increases the rate of proliferation. This therapeutic agent effectively protected the testis against nicotine‐associated damages by antioxidant and anti‐apoptotic effects.
Analysis of poly(dioxanone) foam prepared using salt leaching method
Authors: Kim Jung Min , Kyung Haksu , Song Young Seok 
Published: March 2022

AbstractThis study aims at preparing and analyzing porous biodegradable polymer foam. Poly(dioxanone) (PDO) foams with a three‐dimensional structure and high porosity were fabricated by using sodium chloride (NaCl) particulate leaching method. The influence of the size composition of PDO and NaCl was investigated to understand the relationship between polymer matrix and salt during the manufacturing process. The physical characteristics of the prepared foam, such as moldability, leaching state, porosity, permeability, swelling ratio, pore density, and mechanical property were analyzed. The PDO foams with high dimensional stability were prepared when the PDO particles were smaller than the NaCl particles, and the porosity of the PDO foam increased with decreasing the particle size of PDO. In addition, the compression modulus of the foam was analyzed to estimate a possibility for application in tissue engineering.
Gait as a quantitative translational outcome measure in Angelman syndrome
Authors: Petkova Stela P. , Adhikari Anna , Berg Elizabeth L. , Fenton Timothy A. , Duis Jessica , Silverman Jill L. 
Published: March 2022

AbstractAngelman syndrome (AS) is a genetic neurodevelopmental disorder characterized by developmental delay, lack of speech, seizures, intellectual disability, hypotonia, and motor coordination deficits. Motor abilities are an important outcome measure in AS as they comprise a broad repertoire of metrics including ataxia, hypotonia, delayed ambulation, crouched gait, and poor posture, and motor dysfunction affects nearly every individual with AS. Guided by collaborative work with AS clinicians studying gait, the goal of this study was to perform an in‐depth gait analysis using the automated treadmill assay, DigiGait. Our hypothesis is that gait presents a strong opportunity for a reliable, quantitative, and translational metric that can serve to evaluate novel pharmacological, dietary, and genetic therapies. In this study, we used an automated gait analysis system, in addition to standard motor behavioral assays, to evaluate components of motor, exploration, coordination, balance, and gait impairments across the lifespan in an AS mouse model. Our study demonstrated marked global motoric deficits in AS mice, corroborating previous reports. Uniquely, this is the first report of nuanced aberrations in quantitative spatial and temporal components of gait in AS mice compared to sex‐ and age‐matched wildtype littermates followed longitudinally using metrics that are analogous in AS individuals. Our findings contribute evidence toward the use of nuanced motor outcomes (i.e., gait) as valuable and translationally powerful metrics for therapeutic development for AS, as well as other genetic neurodevelopmental syndromes.Lay SummaryMovement disorders affect nearly every individual with Angelman Syndrome (AS). The most common motor problems include spasticity, ataxia of gait (observed in the majority of ambulatory individuals), tremor, and muscle weakness. This report focused on quantifying various spatial and temporal aspects of gait as a reliable, translatable outcome measure in a preclinical AS model longitudinally across development. By increasing the number of translational, reliable, functional outcome measures in our wheelhouse, we will create more opportunities for identifying and advancing successful medical interventions.
A predictive analysis of learning motivation and reflective thinking skills on computer programming achievement
Authors: Avcı Ümmühan 
Published: March 2022

AbstractLearning computer programming requires acquiring multiple skills to be performed simultaneously. As in many other fields, learning motivation and reflective thinking skills may affect the process of designing and implementing computer programming instruction. This study examines how learning motivation and reflective thinking skills predict academic achievement in computer programming and programming laboratory courses. The participants were 140 undergraduate students enrolled in the Faculty of Engineering. Data were collected by using learning motivation on computer programming courses and reflective thinking skill scales. In the study, multiple linear regression analysis was used for data analysis. The first results showed that reflective thinking and learning motivation predict academic achievement together in programming courses. For academic achievement in the computer programming course, only reasoning was found to be significant and for academic achievement in the programming laboratory course, both reasoning and intrinsic motivation appeared to be significant. Although reasoning showed the highest relationship with academic achievement of computer programming, intrinsic motivation showed the highest relationship with academic achievement of the programming laboratory course. The results of the research were discussed in a way as to guide future studies.
Comparative survival analysis of platinum‐based adjuvant chemotherapy for early‐stage squamous cell carcinoma and adenocarcinoma of the lung
Authors: Hsiao Shih‐Hsin , Chen Wan‐Ting , Chung Chi‐Li , Chou Yu‐Ting , Lin Sey‐En , Hong Shiao‐Ya , Chang Jer‐Hwa , Chang Tzu‐Hao , Chien Li‐Nien 
Published: March 2022

AbstractBackground and PurposeAlthough cytotoxic platinum‐based adjuvant chemotherapy (pACT) has been recommended for patients with completely resected early‐stage (ES) non–small‐cell lung cancer (ES‐NSCLC), therapeutic regimens for NSCLC have evolved in the past two decades. The study was aimed to examine the effectiveness of postoperative pACT for resected ES‐NSCLC patients with squamous cell carcinoma (SCC) or adenocarcinoma (ADC) according to real‐world data.Methods and PatientsInverse probability treatment weighting (IPTW) was used to adjust baseline characteristics between the group receiving pACT and those not receiving any treatment (observation, OBS) within 3 months after curative surgery. Cox regression models were used to compare overall survival (OS) and treatment failure‐free survival (TFS) between the groups.ResultsOf 31,208 patients with ES‐NSCLC, 4700 undergoing complete tumor resection were eligible, with a mean follow‐up period of 4.5 years. The pACT (n = 2347) and OBS (n = 2353) groups were well‐balanced after IPTW. The median OS differed between the pACT and OBS groups (77.2 vs. 75.5 months, adjusted hazard ratio [aHR] = 0.87, 95% confidence interval [CI] = 0.79–0.95, p = 0.003), and the 5‐year survival rates were 58.2% and 55.3%, respectively (p < 0.001). In the SCC group, pACT was superior to OBS in OS (75.0 vs. 57.4 months, aHR = 0.74, 95% CI = 0.62–0.88, p = 0.001) and TFS (32.7 vs. 21.8 months, aHR = 0.74, 95% CI = 0.63–0.86, p < 0.001). Both OS and TFS did not differ between two groups in those with ADC.ConclusionReal‐world data indicated that pACT confers a survival benefit for resected ES‐NSCLC patients with SCC but not ADC, which needs to be verified by a large sample of randomized controlled studies.