bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing and Implementing Deliberative Processes for Health Technology Assessment: A Good Practices Report of a Joint HTAi/ISPOR Task Force
Authors: Oortwijn Wija , Husereau Don , Abelson Julia , Barasa Edwine , Bayani Diana (Dana) , Santos Vania Canuto , Culyer Anthony , Facey Karen , Grainger David , Kieslich Katharina , Ollendorf Daniel , Pichon-Riviere Andrés , Sandman Lars , Strammiello Valentina , Teerawattananon Yot 
Published: June 2022

Abstract

Objectives
Deliberative processes for health technology assessment (HTA) are intended to facilitate participatory decision making, using discussion and open dialogue between stakeholders. Increasing attention is being given to deliberative processes, but guidance is lacking for those who wish to design or use them. Health Technology Assessment International (HTAi) and ISPOR—The Professional Society for Health Economics and Outcomes Research initiated a joint Task Force to address this gap.

Methods
The joint Task Force consisted of fifteen members with different backgrounds, perspectives, and expertise relevant to the field. It developed guidance and a checklist for deliberative processes for HTA. The guidance builds upon the few, existing initiatives in the field, as well as input from the HTA community following an established consultation plan. In addition, the guidance was subject to two rounds of peer review.

Results
A deliberative process for HTA consists of procedures, activities, and events that support the informed and critical examination of an issue and the weighing of arguments and evidence to guide a subsequent decision. Guidance and an accompanying checklist are provided for (i) developing the governance and structure of an HTA program and (ii) informing how the various stages of an HTA process might be managed using deliberation.

Conclusions
The guidance and the checklist contain a series of questions, grouped by six phases of a model deliberative process. They are offered as practical tools for those wishing to establish or improve deliberative processes for HTA that are fit for local contexts. The tools can also be used for independent scrutiny of deliberative processes.
Does it Matter if the President Isn't Pious? White Evangelicals and Elite Religiosity in the Trump Era
Authors: Thompson Jack 
Published: June 2022

AbstractTrump's unwavering support among white evangelicals seems a contradiction considering his seeming irreligiosity and well publicized moral transgressions. This contradiction raises an interesting question concerning whether Trump represents something of a unique case when it comes to white evangelical evaluations of elite religiosity, or whether his support among the group indicative of a new era of evangelical support for candidates that does not assess religiosity as it used to. Drawing on contemporary debates from the religious psychology and Christian nationalism scholarship, I use data from Wave 61 of the American Trends Panel (ATP) to test whether white evangelicals who encounter threats to their religious identities are more likely to view that God played some role in Trump's election. Overall, I find that white evangelicals consider themselves minorities as a result of their beliefs. Most importantly, these beliefs condition white evangelical beliefs about God's role in Trump's election. Specifically, I find that increases in threat perceptions lead to an increase in the probability of a white evangelical believing that Trump's election was part of God's plan. These findings provide a new vantage point for understanding why so many white evangelicals view Trump's election as a divine outcome despite the fact they are indifferent to his irreligiosity.
Using weed emergence and phenology models to determine critical control windows for winter-grown carinata (Brassica carinata)
Authors: Reinhardt Piskackova Theresa A. , Leon Ramon G. 
Published: June 2022

AbstractAdoption of the new biofuel crop carinata (Brassica carinata A. Braun) in the southeastern United States will largely hinge on sound agronomic recommendations that can be economically incorporated into and are compatible with existing rotations. Timing of weed control is crucial for yield protection and long-term weed seedbank management, but predictive weed emergence models have not been as widely studied in winter crops for this purpose. In this work, we use observed and predicted emergence of a winter annual weed community to create recommendations for timing weed control according to weed and crop phenology progression. Observed emergence timings for four winter annual weed species in North Carolina were used to validate previously published models developed for winter annual weeds in Florida by accounting for temperature and daylength differences, and this approach explained more than 70% of the variability in observed emergence. Emergence of stinking chamomile (Anthemis cotula L.) and cutleaf evening primrose (Oenothera laciniata Hill.) followed biphasic patterns comparable to wild radish (Raphanus raphanistrum L.), which were predicted with previously published models accounting for 82% and 84% of the variation, respectively. Using the predictive models for weed emergence and carinata growth, critical control windows (CCW) were estimated for Clayton, NC, and Jay, FL, according to different planting dates. The results demonstrated how early planting coincided with the emergence of three competitive winter weeds, but early control could also remove a large proportion of the predicted emergence of these species. The framework for how planting timing will affect winter weed emergence and crop growth will be an instructive decision-making tool to help prepare farmers to manage weeds in carinata, but it could also be useful for weed management planning for other winter crops.
Sublimation Origin of Negative Deuterium Excess Observed in Snow and Ice Samples From McMurdo Dry Valleys and Allan Hills Blue Ice Areas, East Antarctica
Authors: Hu Jun , Yan Yuzhen , Yeung Laurence Y. , Dee Sylvia G. 
Published: June 2022

AbstractThe oxygen and hydrogen isotopic composition in snow and ice have long been utilized to reconstruct past temperatures of polar regions, under the assumption that post‐depositional processes such as sublimation do not fractionate snow. In low‐accumulation (<0.01 m yr−1) areas near the McMurdo Dry Valleys in Antarctica, surface snow and ice samples have exceptionally low deuterium excess values (d‐excess ≡ δD – 8*δ18O)—sometimes as negative as −5‰—an uncommon phenomenon that is not fully understood. Here we use both an isotope‐enabled general circulation model and an ice physics model and establish that such exceptionally low d‐excess values can only arise from precipitation if the majority of the moisture is sourced from the Southern Ocean (south of 55°S). However, the model results show that moisture sourced from oceans north of 55°S contributes significantly (>50%) to precipitation in Antarctica today. We thus propose that sublimation must have occurred to yield the low d‐excess values in snow observed in and near the Dry Valleys, and that solid‐phase‐diffusion in ice grains is sufficiently fast to allow Rayleigh‐like isotopic fractionation in similar environments. We calculate that under present‐day conditions at the Allan Hills outside the Dry Valleys, 3%–24% of the surface snow is lost due to sublimation. Because the magnitude of sublimation may be nonstationary (i.e., it could vary in time) during past cold periods, we suggest that sublimation‐induced fractionation can alter the relationship between the snow isotopic composition and polar temperatures.
Ion‐Acoustic Waves in a Quasi‐Perpendicular Earth's Bow Shock
Authors: Vasko I. Y. , Mozer F. S. , Bale S. D. , Artemyev A. V. 
Published: June 2022

AbstractWe present analysis of electrostatic waves around the ramp of a quasi‐perpendicular Earth's bow shock observed by the Magnetospheric Multiscale spacecraft. The electrostatic waves have amplitudes up to 800 mV/m, which is the largest value ever reported in the Earth's bow shock. In contrast to previous studies, the electrostatic waves have large amplitudes of the electrostatic potential, up to 20 V or 20% of local electron temperature. The wavelengths are from 150 m to 3 km, that is from 15 to 300 Debye lengths and typically from 0.4 to 1.5 thermal electron gyroradii. Importantly, these waves can propagate not only quasi‐parallel or oblique, but also almost perpendicular to local magnetic field. The electrostatic waves are interpreted in terms of ion‐acoustic waves, although the presence of electron cyclotron harmonic waves cannot be entirely ruled out. These results suggest that electrostatic waves may strongly affect the dynamics of electrons in collisionless shocks.
The Contribution of Planetary Period Oscillations Toward Circulation and Mass Loss in Saturn's Magnetosphere
Authors: Agiwal O. , Masters A. , Hunt G. J. , Dougherty M. K. 
Published: June 2022

AbstractMagnetic reconnection is a process during which magnetic energy is released as kinetic energy. It is considered a crucial driver of energy transport and mass loss within Saturn's magnetosphere. On long‐term timescales, is thought to be predominantly driven by the rapid rotation of equatorially mass‐loaded flux tubes (i.e., the Vasyliunas cycle), but there is some non‐negligible driving from the solar wind as well (i.e., the Dungey cycle). In this study, we investigate an atmospheric driven phenomenon that modulates Saturn's magnetosphere every ∼10.6–10.8 hr, known as planetary period oscillations (PPOs), as an additional driver of magnetic reconnection at Saturn. Using an empirical model of PPO dynamics and Cassini magnetic field and plasma measurements, we find that PPO‐driven magnetic reconnection is likely to occur in Saturn's magnetosphere, however, the occurrence of the phenomenon depends on temporally variable characteristics of the PPO systems and spatial asymmetries within Saturn's equatorial magnetosphere. Thus, it is not expected to be an on‐going process. On year‐long timescales, we find that PPOs are expected to be on par with the Dungey Cycle in driving circulation within Saturn's magnetosphere. However, on ∼1–2 weeks‐long timescales, under specific conditions where PPO‐driven reconnection is expected to be active, this phenomenon can become more significant than the Vasyliunas cycle, and thus dominate circulation within Saturn's magnetosphere. On year‐long timescales, this process is estimated to remove upwards of ∼20% of the mass loaded into the magnetosphere by Enceladus.
The Seasonal Evolution of the Tibetan Plateau Snow Cover Related Moisture During Spring‐to‐Summer
Authors: Zhang Chao , Jia XiaoJing 
Published: June 2022

AbstractThe current work investigated the seasonal evolution of the Tibetan Plateau (TP) snow cover (TPSC) induced atmospheric moisture anomalies from May to August, by analyzing TP snow‐diabatic and TP snow‐hydrological processes during the 1979–2020 period using both observational data and a baroclinic atmospheric model. The results show that the TPSC and its related atmospheric moisture are featured by a westward retreat from the eastern TP in May to the western TP in August. The TPSC variation related atmospheric apparent heat source shows that excessive TPSC can cause local diabatic cooling to the above atmosphere and can be attributed to a local cyclonic pattern in the upper troposphere. This cyclonic pattern also moves westward along with the seasonal evolution of the TP snow during this period. Anomalous TP snow can impact atmospheric moisture through snow melt and snow evaporating process. Associated with the changes in TP snow, its related anomalous atmospheric moisture and circulations, significant moisture divergence appears over the mid‐eastern Himalaya during May and June (MJ) and the water vapor is mainly transported from the Himalaya to southeastern TP regions including Bhutan, Myanmar, Bengal and eastern India. Differently, during July and August (JA), significant atmospheric moisture divergence is located over the mid‐western Himalaya, and the water vapor is mostly transported from the Himalaya to southwestern TP areas including Nepal and western India. Further analysis shows that the TPSC anomaly induced anomalous atmospheric moisture accounts for 22%–45% of the climatological moisture for the mid‐eastern Himalaya during MJ, whereas it accounts for 65%–78% of the climatological moisture for the mid‐western Himalaya during JA.
Distribution and Morphology of Lava Tube Systems on the Western Flank of Alba Mons, Mars
Authors: Crown David A. , Scheidt Stephen P. , Berman Daniel C. 
Published: June 2022

AbstractIntegrated analyses of Thermal Emission Imaging System (THEMIS) IR, Context Camera (CTX), and Mars Orbiter Laser Altimeter (MOLA) data sets have been used to characterize the western flank of the Martian volcano Alba Mons, which hosts a prominent population of lava tube systems. Identification and mapping of lava tube systems is based on both morphologic and topographic analyses, including the presence of chains of collapse depressions and elongate, sinuous ridges. Lava tubes and adjacent tabular lava flows with lengths of 100+ km form an extensive lava flow field. Analyses of topographic data sets, including slope maps, suggest continuity of the radial flow field pattern across the full western flank. Concurrent surface activity across the western flank is consistent with age constraints from geologic mapping and crater size‐frequency distributions that indicate Early Amazonian ages. The mapped population of 331 lava tube systems in the western flank geologic map quadrangle has a mean length of 36.2 km and a total length of ∼12,000 km. Individual lava tube systems extend up to ∼400 km. Orientation and slope data for lava tube systems show small deviations compared to regional values in 50‐km grid cells defined by the MOLA Digital Elevation Model, suggesting a strong coupling of lava tubes to the current slopes of Alba Mons. Mapping of lava tube systems documents segments both showing collapse and with no collapse, indicating the potential for extensive subsurface cavities that would be important astrobiological targets.
Validity of Scottish predictors of child obesity (age 12) for risk screening in mid-childhood: a secondary analysis of prospective cohort study data—with sensitivity analyses for settings without various routinely collected predictor variables
Authors: Carrillo-Balam Gabriela , Doi Lawrence , Marryat Louise , Williams Andrew James , Bradshaw Paul , Frank John 
Published: June 2022

AbstractObjectiveTo analyse the Growing Up in Scotland cohort for predictors of obesity at age 12, present at school entry (age 5–6).MethodsThe initial model included literature-based risk factors likely to be routinely collected in high-income countries (HICs), as well as “Adverse/Protective Childhood Experiences (ACEs/PCEs)”. Missing data were handled by Multiple Chained Equations. Variable-reduction was performed using multivariable logistic regression with backwards and forwards stepwise elimination, followed by internal validation by bootstrapping. Optimal sensitivity/specificity cut-offs for the most parsimonious and accurate models in two situations (optimum available data, and routinely available data in Scotland) were examined for their referral burden, and Positive and Negative Predictive Values.ResultsData for 2787 children with full outcome data (obesity prevalence 18.3% at age 12) were used to develop the models. The final “Optimum Data” model included six predictors of obesity: maternal body mass index, indoor smoking, equivalized income quintile, child’s sex, child’s BMI at age 5–6, and ACEs. After internal validation, the area under the receiver operating characteristic curve was 0.855 (95% CI 0.852–0.859). A cut-off based on Youden’s J statistic for the Optimum Data model yielded a specificity of 77.6% and sensitivity of 76.3%. 37.0% of screened children were “Total Screen Positives” (and thus would constitute the “referral burden”.) A “Scottish Data” model, without equivalized income quintile and ACEs as a predictor, and instead using Scottish Index of Multiple Deprivation quintile and “age at introduction of solid foods,” was slightly less sensitive (76.2%) but slightly more specific (79.2%), leading to a smaller referral burden (30.8%).ConclusionUniversally collected, machine readable and linkable data at age 5–6 predict reasonably well children who will be obese by age 12. However, the Scottish treatment system is unable to cope with the resultant referral burden and other criteria for screening would have to be met.
Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction
Authors: Zhang Fuyang , Hu Guangyu , Chen Xiyao , Zhang Ling , Guo Lanyan , Li Congye , Zhao Hang , Cui Zhe , Guo Xiong , Sun Fangfang , Song Dandan , Yan Wenjun , Xia Yunlong , Wang Shan , Fan Miaomiao , Tao Ling 
Published: June 2022

AbstractMesenchymal stem cells (MSCs) delivered into the post-ischemic heart milieu have a low survival and retention rate, thus restricting the cardioreparative efficacy of MSC-based therapy. Chronic ischemia results in metabolic reprogramming in the heart, but little is known about how these metabolic changes influence implanted MSCs. Here, we found that excessive branched-chain amino acid (BCAA) accumulation, a metabolic signature seen in the post-ischemic heart, was disadvantageous to the retention and cardioprotection of intramyocardially injected MSCs. Discovery-driven experiments revealed that BCAA at pathological levels sensitized MSCs to stress-induced cell death and premature senescence via accelerating the loss of histone 3 lysine 9 trimethylation (H3K9me3). A novel mTORC1/DUX4/KDM4E axis was identified as the cause of BCAA-induced H3K9me3 loss and adverse phenotype acquisition. Enhancing BCAA catabolic capability in MSCs via genetic/pharmacological approaches greatly improved their adaptation to the high BCAA milieu and strengthened their cardioprotective efficacy. We conclude that aberrant BCAA accumulation is detrimental to implanted MSCs via a previously unknown metabolite-signaling-epigenetic mechanism, emphasizing that the metabolic changes of the post-ischemic heart crucially influence the fate of implanted MSCs and their therapeutic benefits.
Thyroid hypogenesis is associated with a novel AKT3 germline variant that causes megalencephaly and cortical malformation
Authors: Mori Jun , Hasegawa Tatsuji , Miyamoto Yosuke , Kitamura Kazumasa , Morimoto Hidechika , Tozawa Takenori , Pooh Ritsuko Kimata , Chiyonobu Tomohiro 
Published: June 2022

AbstractThe molecular mechanisms involved in thyroid organogenesis have not been fully elucidated. We report a patient with a de novo germline AKT3 variant, NM_005465.7:c.233A > G, p.(Gln78Arg), who presented with congenital hypothyroidism in addition to typical AKT3-related brain disorders. The report of this patient contributes to delineating the associated yet uncertain endocrine complications of this AKT3 disease-causing variant.
A TUBB4A Met363Thr variant in pediatric hypomyelination without atrophy of the basal ganglia
Authors: Hashiguchi Marina , Monden Yukifumi , Nozaki Yasuyuki , Watanabe Kazuki , Nakashima Mitsuko , Saitsu Hirotomo , Yamagata Takanori , Osaka Hitoshi 
Published: June 2022

AbstractTUBB4A gene variants cause dystonia type 4 and hypomyelination with atrophy of the basal ganglia and cerebellum. We report the case of a child with delayed motor development, intellectual disability, and dystonia. Magnetic resonance imaging revealed hypomyelination and progressive cerebellar atrophy without atrophy of the basal ganglia. Whole-exome sequencing revealed a de novo heterozygous variant, c.1088T > C, p.(Met363Thr), in TUBB4A. The present case further supports the vulnerability of the cerebellum in patients with TUBB4A pathogenic variants.
All-optical switching based on plasmon-induced Enhancement of Index of Refraction
Authors: Dhama Rakesh , Panahpour Ali , Pihlava Tuomas , Ghindani Dipa , Caglayan Humeyra 
Published: June 2022

AbstractIn quantum optical Enhancement of Index of Refraction (EIR), coherence and quantum interference render the atomic systems to exhibit orders of magnitude higher susceptibilities with vanishing or even negative absorption at their resonances. Here we show the plasmonic analogue of the quantum optical EIR effect in an optical system and further implement this in a linear all-optical switching mechanism. We realize plasmon-induced EIR using a particular plasmonic metasurface consisting of a square array of L-shaped meta-molecules. In contrast to the conventional methods, this approach provides a scheme to modulate the amplitude of incident signals by coherent control of absorption without implementing gain materials or nonlinear processes. Therefore, light is controlled by applying ultra-low intensity at the extreme levels of spatiotemporal localization. In the pursuit of potential applications of linear all-optical switching devices, this scheme may introduce an effective tool for improving the modulation strength of optical modulators and switches through the amplification of input signals at ultra-low power.
Low-degree mantle melting controls the deep seismicity and explosive volcanism of the Gakkel Ridge
Authors: Koulakov Ivan , Schlindwein Vera , Liu Mingqi , Gerya Taras , Jakovlev Andrey , Ivanov Aleksey 
Published: June 2022

AbstractThe world’s strongest known spreading-related seismicity swarm occurred in 1999 in a segment of the Gakkel Ridge located at 85°E as a consequence of an effusive-explosive submarine volcanic eruption. The data of a seismic network deployed on ice floes were used to locate hundreds of local earthquakes down to ∼25 km depth and to build a seismic tomography model under the volcanic area. Here we show the seismicity and the distribution of seismic velocities together with the 3D magmatic-thermomechanical numerical model, which demonstrate how a magma reservoir under the Gakkel Ridge may form, rise and trigger volcanic eruptions in the rift valley. The ultraslow spreading rates with low mantle potential temperatures appear to be a critical factor in the production of volatile-rich, low-degree mantle melts that are focused toward the magma reservoirs within narrow magmatic sections. The degassing of these melts is the main cause of the explosive submarine eruptions.
Lattice-mismatch-free growth of organic heterostructure nanowires from cocrystals to alloys
Authors: Lv Qiang , Wang Xue-Dong , Yu Yue , Zhuo Ming-Peng , Zheng Min , Liao Liang-Sheng 
Published: June 2022

AbstractOrganic heterostructure nanowires, such as multiblock, core/shell, branch-like and related compounds, have attracted chemists’ extensive attention because of their novel physicochemical properties. However, owing to the difficulty in solving the lattice mismatch of distinct molecules, the construction of organic heterostructures at large scale remains challenging, which restricts its wide use in future applications. In this work, we define a concept of lattice-mismatch-free for hierarchical self-assembly of organic semiconductor molecules, allowing for the large-scale synthesis of organic heterostructure nanowires composed of the organic alloys and cocrystals. Thus, various types of organic triblock nanowires are prepared in large scale, and the length ratio of different segments of the triblock nanowires can be precisely regulated by changing the stoichiometric ratio of different components. These results pave the way towards fine synthesis of heterostructures in a large scale and facilitate their applications in organic optoelectronics at micro/nanoscale.