bluuebunny/crossref_metadata_2025_split huggingface dataset:
A description of the genusDenitromonasnom. rev.:Denitromonas iodatirespiranssp. nov. a novel iodate-reducing bacterium and two novel perchlorate-reducing bacteriaDenitromonas halophilaandDenitromonas ohlonensisisolated from San Francisco Bay intertidal mudflats
Authors: Reyes-Umana Victor M. , Coates John D. 
Published: October 2022

AbstractThe genusDenitromonasis currently a non-validated taxon that has been identified in several recent publications as members of microbial communities arising from marine environments. Very little is known about the biology ofDenitromonasspp., and no pure cultures are presently found in any culture collections. The current epitaph ofDenitromonaswas given to the organism under the assumption that all members of this genus are denitrifying bacteria. This study performs phenotypic and genomic analyses on three newDenitromonasspp. isolated from tidal mudflats in the San Francisco Bay. We demonstrate thatDenitromonasspp. are indeed all facultative denitrifying bacteria that utilize a variety of carbon sources such as acetate, lactate, and succinate. In addition, individual strains also use the esoteric electron acceptors perchlorate, chlorate, and iodate. Both 16S and Rps/Rpl phylogenetic analyses placeDenitromonasspp. as a deep branching clade in the familyZoogloeaceae, separate from eitherThaueraspp.,Azoarcusspp., orAromatoleumspp. Genome sequencing reveals a G+C content ranging from 63.72% to 66.54%, and genome sizes range between 4.39-5.18 Mb. Genes for salt tolerance and denitrification are distinguishing features that separateDenitromonasspp. from the closely relatedAzoarcusandAromatoleumgenera.
Uterine histotroph and conceptus development. III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway
Authors: Liu Bangmin , Paudel Sudikshya , Flowers William L , Piedrahita Jorge A , Wang Xiaoqiu 
Published: October 2022

ABSTRACTAdrenomedullin (ADM) as a highly conserved peptide hormone has been reported to increase significantly in the uterine lumen during the peri-implantation period of pregnancy in pigs, but its functional roles in growth and development of porcine conceptus (embryonic/fetus and its extra-embryonic membranes) as well as underlying mechanisms remain largely unknown. Therefore, we conductedin vitroexperiments using our established porcine trophectoderm cell line (pTr1) isolated from Day-12 porcine conceptuses to test the hypothesis that porcine ADM stimulates cell proliferation, migration and adhesion via AKT-TSC2-MTOR cell signaling pathway in pTr1 cells. Porcine ADM at 10-7M stimulated (P<0.05) pTr1 cell proliferation, migration and adhesion by 1.4-, 1.5- and 1.2-folds, respectively. These ADM-induced effects were abrogated (P<0.05) by siRNA-mediated knockdown of ADM (siADM) and its shared receptor component calcitonin-receptor-like receptor (CALCRL; siCALCRL), as well as by rapamycin, the inhibitor of mechanistic target of rapamycin (MTOR). Using siRNA mediated knockdown of CALCRL coupled with Western blot analyses, ADM signaling transduction was determined in which ADM binds to CALCRL to increase phosphorylation of MTOR, its downstream effectors (4EBP1, P70S6K, and S6), and upstream regulators (AKT and TSC2). Collectively, these results suggest that porcine ADM in histotroph act on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation,migration and attachment of conceptuses.
“Divergent TLR2 and TLR4 activation by fungal spores and species diversity in dust from waste-sorting plants”
Authors: Afanou Anani K , Mundra Sunil , Fjeld Estensmo Eva Lena , Pedersen Ine , Liland Jens Rasmus , Eriksen Elke , Graff Pål , Hildre Tonje Trulssen , Nordby Karl-Christian , Straumfors Anne 
Published: October 2022

1.AbstractThis manuscript presents the results of an exploratory study on the relationships between NFkB (Nuclear Factor Kappa Chain Enhancer of B-cells) response through TLRs activation by dust characterized by fungal spore concentrations and species diversity. Personal total dust samples were collected from Norwegian waste sorting plants and then characterized for fungal spores and fungal species diversity, as well as for other bioaerosol components, including endotoxins and actinobacteria. The ability of the dust to induce an NFkB response by activating Toll-like receptors 2 (TLR2) and 4 (TLR4) in vitro was evaluated as well as the relationship between such responses and quantifiable bioaerosol components. The average concentrations of bioaerosols were 7.23 mg total dust m−3, 4.49×105fungal spores m−3, 814 endotoxin units m−3, and 0.6×105actinobacteria m−3. The mean diversity measurements were 326; 0.59 and 3.39 for fungal richness, evenness, and Shannon Index, respectively. Overall, fungal OTUs belonging to the Ascomycotina phylum were most abundant (55%), followed by Basidiomycota (33%) and Mucormycota (3%). All samples induced significant NFkB responses through TLR2 and TLR4 activation. While fungal spore levels were positively associated with TLR2 and TLR4 activation, there was a trend that fungal species richness was negatively associated with the activation of these receptors. This observation supports the existence of divergent immunological responses relationship between fungal spore levels and fungal species diversity. Such relationships seem to be described for the first time for dust from waste facilities.
Characterizing biofilm interactions betweenRalstonia insidiosaandChryseobacterium gleum
Authors: Foote Andrea , Schutz Kristin , Zhao Zirui , DiGianivittorio Pauline , Korwin-Mihavics Bethany R. , LiPuma John J. , Wargo Matthew J. 
Published: October 2022

AbstractRalstonia insidiosaandChryseobacterium gleumare bacterial species commonly found in potable water systems and these two species contribute to the robustness of biofilm formation in a model six-species community from the International Space Station (ISS) potable water system. Here, we set about characterizing the interaction between these two ISS-derived strains and examining the extent to which this interaction extends to other strains and species in these two genera. The enhanced biofilm formation between the ISS strains ofR. insidiosaandC. gleumis robust to starting inoculum and temperature, occurs in some but not all tested growth media, and evidence does not support a soluble mediator or co-aggregation mechanism. These findings shed light on the ISSR. insidiosaandC. gleuminteraction, though such enhancement is not common between these species based on our examination of otherR. insidiosaandC. gleumstrains, as well as other species of Ralstonia and Chryseobacterium. Thus, while the findings presented here increase our understanding of the ISS potable water model system, not all our findings are broadly extrapolatable to strains found outside of the ISS.ImportanceBiofilms present in drinking water systems and terminal fixtures are important for human health, pipe corrosion, and water taste. Here we examine the enhanced biofilm of cu-cultures for two very common bacteria from potable water systems,Ralstonia insidiosaandChryseobacterium gleum. While strains originally isolated on the International Space Station show enhanced dual-species biofilm formation, terrestrial strains do not show the same interaction properties. This study contributes to our understanding of these two species in both dual and mono-culture biofilm formation.
Structure of the Inmazeb cocktail and resistance to escape against Ebola virus
Authors: Rayaprolu Vamseedhar , Fulton Ben , Rafique Ashique , Arturo Emilia , Williams Dewight , Hariharan Chitra , Callaway Heather , Parvate Amar , Schendel Sharon L. , Parekh Diptiben , Hui Sean , Shaffer Kelly , Pascal Kristen , Wloga Elzbieta , Giordano Stephanie , Copin Richard , Franklin Matthew , Boytz RuthMabel , Donahue Callie , Davey Robert , Baum Alina , Kyratsous Christos A. , Saphire Erica Ollmann 
Published: October 2022

AbstractMonoclonal antibodies can provide important pre- or post-exposure protection against disease for those not yet vaccinated or in individuals that fail to mount a protective immune response after vaccination. A key concern in use of monotherapy monoclonal antibody products lies in the high risk of mutagenic escape. Inmazeb (REGN-EB3), a three-antibody cocktail against Ebola virus, demonstrated efficacy in lessening disease course and improving survival in a randomized, controlled trial. Here we present the cryoEM structure at 3.1 Å of the Ebola virus glycoprotein, determined without symmetry averaging, in a simultaneous complex with eight Fab fragments of antibodies in the Inmazeb cocktail. This structure allows modeling of previously disordered portions of the glycan cap, maps the non-overlapping epitopes of Inmazeb, and illuminates the basis for complementary activities, as well as residues that are critical for resistance to escape by each component of this cocktail and other clinically relevant antibodies. We also provide direct evidence that, unlike monotherapy treatments, including those targeting conserved epitopes, the Inmazeb protects against the rapid emergence of EBOV escape mutants and supports the benefit of the combination approach.
Redefining the construction managerial landscape to facilitate Industry 4.0 implementation: scientometric mapping of research frontiers
Authors: Ghosh Arka , Abawajy Jemal , Chowdhury Morshed 
Published: October 2022

Purpose
This study aims to provide an excellent overview of current research trends in the construction sector in digital advancements. It provides a roadmap to policymakers for the effective utilisation of emergent digital technologies and a need for a managerial shift for its smooth adoption.

Design/methodology/approach
A total of 3,046 peer-reviewed journal review articles covering Internet of Things (IoT), blockchain, building information modelling (BIM) and digital technologies within the construction sector were reviewed using scientometric mapping and weighted mind-map analysis techniques.

Findings
Prominent research clusters identified were: practice-factor-strategy, system, sustainability, BIM and construction worker safety. Leading countries, authors, institutions and their collaborative networks were identified with the UK, the USA, China and Australia leading this field of research. A conceptual framework for an IoT-based concrete lifecycle quality control system is provided.

Originality/value
The study traces the origins of the initial application of Industry 4.0 concepts in the construction field and reviews available literature from 1983 to 2021. It raises awareness of the latest developments and potential landscape realignment of the construction industry through digital technologies conceptual framework for an IoT-based concrete lifecycle quality control system is provided.
The lived experience of freedom among entrepreneurs with disabilities
Authors: Hidegh Anna Laura , Svastics Carmen , Győri Zsuzsanna , Csillag Sara 
Published: October 2022

PurposeWhile it is argued that entrepreneurship provides considerable freedom, it is also underlined that it might have the potential for exclusion and oppression. The study contributes to this debate and aims to investigate how entrepreneurs with disabilities (EWD) ascribe meaning to freedom in a contested terrain informed by entrepreneurial autonomy as well as constraints due to impairments and an ableist social environment.Design/methodology/approachThe study uses a qualitative approach and builds upon the critical concepts of negative, positive and social freedom as a theoretical lens for the in-depth analysis of the twenty-nine semi-structured interviews with EWD in Hungary.FindingsFindings indicate that EWD experiences freedom in ambivalent ways. Engaging in the discourse of entrepreneurship offers a subversive discursive toolkit to debunk the constraints established by ableism, enabling both negative and positive freedom. However, individualism being at the heart of entrepreneurship results in othering and undermines social freedom. Thus, while entrepreneurship offers greater individual freedom in both a negative and a positive sense for people with disabilities (PWD), it nevertheless fails to promote collective social change.Originality/valueContributing to the critical disability literature, findings contrast the view that having an impairment only reduces a person's abilities and highlight that it also affects the very nature of liberty. Contributing to critical studies on entrepreneurship, the case of EWD provides empirical evidence for understanding the simultaneous emancipatory and oppressive character of entrepreneurship through the interplay of the subjective experience of freedom related to disability and entrepreneurship.
Assessment of attitudes toward patient rights of people live from a Turkey town and migrating to Belgium
Authors: Korkmaz Vahide , Demirsoy Nilüfer 
Published: October 2022

Purpose
The purpose of this study is to assess the attitudes of individuals living in Belgium and in Emirdag in regard to patient rights and the effect of cultural differences in developing the attitude. This study measures the attitudes of two groups of people living in different geographies, “individuals living in Emirdag and Individuals emigrated from Emirdag to Belgium,” and yet having the same ethnic origin, common social and cultural capital.

Design methodology/approach
Implementing quantitative research, the data for the current study was obtained from a total of 1,043 participants, who were administered the Likert type “Patient Rights Attitude Scale” along with demographic questionnaire.

Findings
The total score mean of the scale is 126.09 ± 15.21 in the Emirdag group, whereas in the Belgian group, it is 129.78 ± 13.356. While the attitude with the highest mean score about patient rights in both groups observed under “the right to seek medical attention” and “the right to consent in medical and drug researches” items and thusthese items are considered as a common denominator, the two groups differed in the scale items that received the lowest average.

Social implications
It is important to determine the effects of attitudes toward patient rights and cultural differences on the development of attitudes, to determine the problems in the delivery of health services and health service procurement.

Originality/value
The structures that direct the choices and decisions of individuals in critical subjects such as organ transplantation and euthanasia, and thus having different practices in the doctrine, can be affected by individuals and even society’s rules, beliefs and values. It was concluded that immigrant participants’ dominating culture and related beliefs, rules and values play a role in the making of decision and choice.
Stochastic analysis of a non-identical three units repairable system with operational priority to simultaneously working of identical units
Authors: Malik Suresh Chander , Kadyan Sweety 
Published: October 2022

PurposeThe purpose of present study is to carry out stochastic analysis of some important reliability measures of a three-unit system where there are two types of units called type-I and type-II. In type-II, two identical units work simultaneously to meet the system requirements while in type-I, a single unit is kept in spare and can be used to work whenever required at the failure of either of the units of type-II. The system starts its operation with type-II units and thus priority is given to the operation of type-II units. The type II units are different to type-I unit but can perform the same task. There is a single server who handles repair activities of both type of units and the units are assumed to be in pristine condition after every repair. Failures of both types of units are independent and constant. The system can fail at the failure of either of the type-II units and type-I unit.Design/methodology/approachSemi-Markov process and regenerative point technique are used to study the behaviour of different reliability measures of the system.FindingsIn this paper, a three-unit non-identical repairable system is analysed stochastically and its reliability characteristics such as transition probabilities (TP), mean sojourn time (MST), MTSF, steady state availability, expected number of repairs of units, expected number of visits of the repairman and expected busy period of repairman are derived to carry out profit analysis.Research limitations/implicationsThe direct application of the present study can be seen is case of a power distribution system where solar panels may be considered as type-II units and transformer as the type-I unit. Here, the case study is carried out by using approximate data from some old studies; however, a study with accurate data would be more preferable.Originality/valueThis paper is one of the few reliability studies conducted on a system with simultaneous working units. Also, the comparative study of the profit of the present system model has been done with that of the model Kadyan et al. (2020a).
Social media influencers’ community and content strategy and follower engagement behavior in the presence of competition: an Instagram-based investigation
Authors: Tafesse Wondwesen , Wood Bronwyn P. 
Published: October 2022

Purpose
Drawing on insights from social influence theory, the MAIN model of digital media affordances and the literature on the attention economy, this study aims to investigate how social media influencers’ community and content strategy contribute to follower engagement behavior in the presence of competition.

Design/methodology/approach
This study used a web-scraped data set of Instagram influencers. It measured community strategy using influencers’ number of followers, number of following and breadth of interest; content strategy using modality type and number of posts; competition using number of influencers operating in the same primary domain of interest; and follower engagement behavior using number of likes and comments. A negative binomial regression model was estimated to test the proposed hypotheses.

Findings
The findings reveal that elements of influencers’ community and content strategies, such as number of followers, modality type and number of posts, influence follower engagement behavior. Similarly, competition significantly influences follower engagement behavior both independently and by interacting with influencers’ community and content strategy.

Practical implications
The findings offer insight for brands to identify suitable influencers for partnerships. For instance, brands can judge influencers’ suitability for partnership based on how many followers they have, how many posts they share and how many competitors they have. Further, the findings offer insight for influencers on how they can drive follower engagement behavior by managing their social media community and content.

Originality/value
This study develops an integrated model of factors that determine follower engagement behavior for social media influencers. The findings emphasize influencers’ strategy as the primary driver of follower engagement behavior. Extant studies focus on followers’ motivation and perception to explain follower engagement behavior while the role of influencers’ strategy is underplayed.
Fintech and Islamic banking growth: new evidence
Authors: Sidaoui Mouwafac , Ben Bouheni Faten , Arslankhuyag Zandanbal , Mian Samuele 
Published: October 2022

PurposeThe purpose of this study is to evaluate the global developments in the area of fintech solutions by analyzing Islamic and Conventional banks core accounting and market analysis IFIs and their impact on financial inclusion within its core markets.Design/methodology/approachThe authors collect and analyze annual accounting and market Data of the top ten largest Islamic banks and the top ten US Conventional banks, in terms of Total Asset and Market Capitalization, from Bloomberg Data.FindingsThe analysis of Bloomberg data shows higher risk-return for Islamic banks–except ROE Market measure that we suggest-than US conventional banks. Nonetheless, Islamic banking grew faster than conventional banking over the period 2006–2021. As a business model, we find that Islamic banks take more credit with more than seventy percent of their profit from loans, while US conventional banks struggle to reach seventy percent interest rate ratio. The authors’ research documents that Fintech and digitalization are driving Islamic finance growth during financial and economic downturns.Research limitations/implicationsFinTech data is not available for banks, further insights of analysis on FinTech and Innovations in the banking sectors.Practical implicationsIslamic banks continuously innovate to satisfy the users of their services and Fintech is opportune to innovation. This study could be interesting for both practitioners and academics wishing to understand and compare Islamic and conventional banking futures.Social implicationsThe authors compared two banking systems, the US and Islamic Banks, which could be useful for users to differentiate between those banking operations.Originality/valueThe authors collected accounting and market data from Bloomberg of top 10 Islamic and top 10 US Conventional banks from 2006 to 2021 to examine Risk-Return, Growth and Business Model of those banks. The authors propose a new Risk-Return measure ROE-Market and its volatility.
How managers approach data analytics: a typology through a Resource Orchestration perspective
Authors: Peterson Jonathan , Tahssain-Gay Loubna , Salvetat David , Perez Fabienne , Hennekam Sophie 
Published: October 2022

PurposeThis article aims to examine the factors that influence how managers approach data analytics.Design/methodology/approachThe authors draw on content analysis of 34 in-depth interviews with managers in various sectors in France.FindingsUsing Resource Orchestration Theory as the theoretical lens, the findings show that an understanding of the importance of data analytics, having the skills to effectively use data analytics and the capability to integrate data analytics throughout organizations impact the approach adopted by managers. Based on these interrelated factors, a typology of four different approaches is identified: buyer-users, segmenters, promoters and implementers.Research limitations/implicationsThe authors' study reflects results from multiple industries instead of one particular sector. Delving deeper into the practices of distinct sectors with respect to the authors' typology would be of interest.Practical implicationsThe study points to the role of managers and more specifically managers' perception of the opportunities and challenges related to data analytics. These perceptions emerge in managers' skills and capacity to understand and integrate dimensions of data analytics that go beyond one's areas of expertise in order to create capabilities towards an organization's advantage.Originality/valueThe authors contribute by revealing three interrelated factors influencing how managers approach data analytics in managers' organizations. The authors address the need expressed by practitioners to better identify factors responsible for adoption and effective use of data analytics.