bluuebunny/crossref_metadata_2025_split huggingface dataset:
New synthetic peptides on nuclear localization signal derived from jun by single amino acid substitutions
Authors: Chida Kazuhiro , Tagawa Tomoko , Nagamori Shushi , Kuroki Toshio 
Published: November 2022

Abstract:
We examined nuclear transport activities of synthetic peptides on the basis of nuclear localization signal (NLS) of Jun, Arg-Lys-Arg-Lys-Leu, by microinjection into the cytoplasm of NRK cells. Each amino acids of this sequence was replaced by protein or nonprotein amino acids. The four basic amino acids could be replaced by either lysine, arginine or omithine (Om). Replacement of the leucine by a methionine enhanced the transport activity. A nonprotein amino acid sequence Om-Om-Om-Om-Nrv (norvaline) functioned as a NLS.
The promiscuous active site specificity /binding preferences of the fungal aspartic proteinase, rhizopuspepsin
Authors: Lowther W. Todd , Dunn Ben M. 
Published: November 2022

Abstract:
Rhizopuspepsin, a secreted proteinase from the fungus Rhizopus chinensis, has been used as a model system for studying the active site interactions of the aspartic proteinases. Substrates containing systematic substitutions at P5-P1 and P2-P1 were analyzed in an effort to identify molecular interactions that could be exploited in structure-based drug design. The recombinant enzyme showed a high degree of kinetic similarity to naturally occurring isozymes. Rhizopuspepsin was able to cleave substrates with side chains varying widely in size, shape, charge and hydrophobicity. Specificity constant (k,,/Km) values (0.06 to 3.84 s·1µM·1) were consistently two to five-fold higher than for the same peptides studied with the mammalian enzymes, porcine pepsin, cathepsin D and cathepsin E. The structural basis for this broad specificity, particularly in the S, subsite, was rationalized to be a result of glycine residues present at positions 290 and 292.
Outlook of Ferroptosis-Targeted Lipid Peroxidation in Cardiovascular Disease
Authors: Wu Ze-Fan , Liu Xi-Yan , Deng Nian-Hua , Ren Zhong , Jiang Zhi-Sheng 
Published: November 2022

Abstract:Lipid metabolism is a complex biochemical process that regulates normal cell activity and death. Ferroptosis is a novel mode of programmed cell death different from apoptosis, pyroptosis, and autophagy. Abnormal lipid metabolism may lead to lipid peroxidation and cell rupture death, which are regulated by lipoxygenase (LOX), long-chain acyl-coA synthases, and antioxidant enzymes. Alternatively, Fe2+ and Fe3+ are required for the activity of LOXs and ferroptosis, and Fe2+ can significantly accelerate lipid peroxidation in ferroptosis. Abnormal lipid metabolism is a certain risk factor for cardiovascular disease. In recent years, the important role of ferroptosis in developing cardiovascular disease has been increasingly reported. Reducing lipid accumulation could reduce the occurrence of ferroptosis, thus alleviating cardiovascular disease deterioration. This article reviews the relationship of lipid peroxidation to the general mechanism of ferroptosis and highlights lipid peroxidation as the common point of ferroptosis and cardiovascular disease.
Implementation of Quality by Design Approach for Optimization of
RP-HPLC Method for Quantification of Abiraterone Acetate in Solid
Dispersion in Forced Degradation Studies
Authors: Choudhari Manisha , Donthi Mahipal Reddy , Damle Shantanu , Singhvi Gautam , Saha Ranendra Narayan , Dubey Sunil Kumar 
Published: November 2022

Background:
Abiraterone acetate is a derivative of steroidal progesterone, used as a first-line therapy for metastatic castration of prostate cancer.

Objective:
The present study encompasses the design of an experiment approach for developing a simple, reliable, and rapid RP-HPLC method for the estimation of abiraterone acetate.

Method:
The chromatographic separation was efficiently conducted on a Hypersil Gold C18 (50 x 4.6 mm, 5 µm) HPLC column, using the mobile phase composition of acetonitrile: dibasic potassium phosphate (0.01 mM) in the ratio of 80:20 (%v/v) at pH 6.5 with an isocratic elution mode. Furthermore, the different force degradation study including hydrolysis, oxidation, thermal, and photolytic was performed for abiraterone acetate.

Result:
The dynamic linearity was established in the concentration range of 0.5-10 µg/mL with r2 of 0.9998. Furthermore, the limit of detection and the limit of quantitation were 0.0978 µg/mL and 0.3260 µg/mL. The degradation of abiraterone acetate was shown in both acidic (54.16 ± 0.247 after 24 hrs) and basic conditions (35.06 ± 0.458 after 24 hrs). Furthermore, the developed method was successfully employed to quantify abiraterone acetate in bulk powder and the solid dispersion did not show any change in the retention time.

Conclusion:
The developed method was validated according to the ICH Q2 (R1) specification, which was found to be sensitive, accurate, precise, robust, linear, and selective compared to the reported chromatographic method.
Tren ngopi di Jakarta: Analisis rekomendasi kedai kopi pada akun Instagram
Authors: Pratiwi Narita , Widhiasti Maria Regina 
Published: November 2022

Berdasarkan rekam jejak digital, jumlah kedai kopi di Jakarta mengalami peningkatan sejak tahun 2015. Peningkatan ini menjadi indikasi bahwa kedai kopi bukan hanya dijadikan sebagai tempat untuk menikmati kopi melainkan untuk bertemu teman, mengerjakan tugas, maupun untuk sekedar berfoto. Kedai kopi dijadikan sebagai ruang yang merepresentasikan tren pada gaya hidup urban. Artikel ini bertujuan untuk menganalisis tren ngopi di Jakarta, Bogor, Depok, Tangerang dan Bekasi dengan menyelidiki unggahan konten rekomendasi kedai kopi dari akun Instagram @jakartacoffeespot. Dengan menganalisis secara tekstual 262 unggahan @jakartacoffeespot dalam kurun waktu 2 tahun terlihat pola penamaan dengan campuran Bahasa Indonesia dengan bahasa asing yang menegaskan interaksi budaya global-lokal. Selain itu, hasil analisis menunjukkan hegemoni maskulinitas yang diartikulasikan melalui desain industrial dan warna gelap yang mendominasi gaya arsitektur kedai kopi di Jakarta dan sekitarnya pada kurun waktu 2019-2021. Dua temuan penelitian ini memperlihatkan identitas penduduk urban yang multikultural dan didominasi oleh karakteristik maskulinitas.

Based on digital track records, the number of coffee shops in Jakarta has increased since 2015. This is an indication that coffee shops are not only used as a place to enjoy coffee but a place to meet friends, do assignments, or just take pictures. Coffee shops are used as a space that represents trends in urban lifestyles. This article aims to analyze coffee trends in Jakarta, Bogor, Depok, Tangerang, and Bekasi by investigating the uploads of coffee shops recommendation contents from the @jakartacoffeespot Instagram account. By using textual analysis, 262 uploads of @jakartacoffeespot within a period of 2 years are analyzed. It is found that there are patterns of coffee shops’ naming using a combination of Indonesian and foreign languages. ​​This emphasizes global-local culture interactions. In addition, the analysis also shows the hegemonic masculinity which is articulated through industrial designs and dark colors that dominate the architectural style of coffee shops in Jakarta and its surroundings in the 2019-2021 period. The findings of this study show that urban societies are multicultural and dominated by masculinity characteristics.
Tingkat preferensi wanita obesitas pada busana kerja berbahan kain tradisional lurik
Authors: Utami Putri , Wening Sri , Budiastuti Emy , Jerusalem Moh. Adam 
Published: November 2022

Obesitas menjadi masalah tersendiri bagi wanita yang bekerja kantor, sebab mereka kesulitan mendapatkan busana yang cocok untuk dirinya. Penelitian ini bertujuan untuk: (1) menghasilkan busana kerja berbahan lurik untuk wanita obesitas, (2) mengetahui tingkat preferensi wanita obesitas pada busana kerja berbahan lurik. Jenis penelitian ini merupakan penelitian Research & Development dengan desain 4D. Subjek penelitiannya adalah dosen dan karyawan di lingkungan Fakultas Teknik UNY. Instrumen yang digunakan angket tertutup. Teknik analisis data yang dilakukan adalah statistik deskriptif. Penelitian ini menghasilkan busana kerja berbahan lurik dengan penempatan motif pada bagian sisi secara vertikal, berbahan katun dan berwarna gelap. Hasil penelitian menunjukkan bahwa tingkat preferensi wanita obesitas pada busana kerja berbahan lurik paling besar pada aspek pemilihan siluet busana yaitu 28,90%, kemudian pemilihan warna 23%, diikuti pemilihan bahan 20,60%, pemilihan motif 14,5% dan yang terakhir adalah pemilihan tekstur sebesar 13%. Busana kerja berbahan lurik dapat menjadi pilihan yang tepat untuk menciptakan visual badan yang lebih ramping sehingga diharapkan menjadi solusi untuk wanita obesitas untuk meningkatkan rasa percaya diri. Wanita obesitas dapat menggunakan model busana kerja tersebut sebagai solusi agar penampilannya terlihat lebih menarik.

Obesity is a problem for women who work in an office, because they have difficulty getting clothes that fit them. This study aims to: (1) produce work clothes made of striated for obese women, (2) determine the level of preference of obese women on work clothes made of striated. This type of research is a Research & Development research with a 4D design. The research subjects were lecturers and staff at the Faculty of Engineering, UNY. The instrument used was a closed questionnaire. The data analysis technique used was descriptive statistics. This research produces work clothes made of striated with the placement of motifs on the sides vertically, made of cotton and dark in color. The results showed that the level of preference for obese women in work clothes made of striated was greatest in the aspect of choosing a fashion silhouette, namely 28.90%, then color selection 23%, followed by material selection 20.60%, motif selection 14.5% and the last is texture selection by 13%. Work clothes made of striated can be the right choice to create a slimmer body visual so that it is expected to be a solution for obese women to increase their self-confidence. Obese women can use the work dress model as a solution to make their appearance look more attractive.
Paper Birch and Fireweed Stand Establishment Decision Aids
Authors: D'Anjou Brian , Turner Jennifer 
Published: November 2022

The Coastal Western Hemlock submaritime biogeoclimatic subzones (CWHds1 and ds2) occur in the inland valleys of coastal British Columbia, where the climate is commonly transitional between the province's coastal and interior regions. Vegetation management issues in these subzones include species such as fireweed (Epilobium angustifolium) and paper birch (Betula papyrifera). On wetter, rich sites of the CWH zone, management options for other vegetation (e.g., salmon-berry, devil's club, and elderberry) are well documented; however, little research has focussed on the competing species found primarily in the submaritime British Columbia subzones.A field guide for the region (Green and Klinka 1994) lists a number of vegetation concerns for the CWH's submaritime subzones. Practitioners, however, have identified a need for more information about paper birch and fireweed. The vegetation management Stand Establishment Decision Aids (SEDAS) included in this extension note are designed to fill this gap. Although initially developed to address the needs of coastal managers, much of the information presented here can be applied to other areas of the province experiencing similar issues related to successful conifer regeneration. Most of the content was adapted from previously published information on paper birch and fireweed management in the former Cariboo Forest Region (Swift and Turner 2002).The majority of the information provided for paper birch emanates from research conducted in the province's southern interior (Simard 1996; Simard and Henigman 1996), where birch is well distributed and can affect crop tree regeneration and survival. Earlier legislation required free-growing trees to be 150% of the height of competing vegetation; however, the relatively small canopy of paper birch compared to other hardwood species such as alder makes it a less serious deterrent to conifer development. Therefore, foresters working in the CWH's submaritime subzones must determine the effect that existing levels of birch will have on the short- and long-term growth of crop trees. Additionally, research has shown that birch within a regenerating stand of Douglas-fir are beneficial to ectomycorrhizal development (see Jones et al. 1997; Simard et al. 1997a and b). Licensees working in submaritime subzones, where a shift from timber-oriented objectives to ecosystem biodiversity and long-term site productivity objectives may occur, could greatly benefit from further research into the effects of paper birch on regeneration. This extension note provides a general guide for managing paper birch and fireweed in the Coast Forest Region. Peterson et al. (1997) provide a more complete discussion of paper birch throughout the majority of its range. Additional information sources for both paper birch and fireweed are listed in the Resource and Reference sections.
Central Interior Ecoregional Assessment: Terrestrial Representation in Regional Conservation Plannning
Authors: Kittel Gwen , Cadrin Carmen , Markovic Dušan , Stevens Tory 
Published: November 2022

This article describes the approach used to incorporate terrestrial ecological systems into regional conservation planning as part of the ecoregional assessment completed by the Nature Conservancy of Canada for the Central Interior of British Columbia, a vast area of 25.7 million ha. The goal of our assessment was to develop a suite of conservation areas that, once protected or managed for conservation, would represent all of the biodiversity and ecosystem functions of the Central Interior. The process involved several teams focussed on different areas (aquatic and terrestrial ecosystems; plant, and animal species).This article describes the efforts of the terrestrial coarse-scale ecological systems team. We developed an ecological systems classification to be used as coarse-filter argets, created an ecoregion-wide map of distribution, and modelled distributions of riparian ecosystems and fine-scale ecological land units to capture elevation and micro-topographic slope and aspect diversity. We also developed minimum dynamic area criteria for large-scale forest ecosystems. The final set of prioritized potential conservation areas covers 7.7 million ha (30%) of the Central Interior. We also integrated climate adaptive strategies into a plan that included large, enduring landscapes with topographic diversity, which allows for species movement or migration and populations of species at the northern limit of their range within the Central Interior.
Expected Effects of Climate Change on Forest Disturbance Regimes in British Columbia
Authors: Haughian Sean R. , Burton Philip J. , Taylor Steve W. , Curry Charles 
Published: November 2022

Projections for forest disturbance and damage under a changing climate in British Columbia are summarized, with the objective of collating regionally specific expectations so that land managers can take pro-active steps to avoid or adapt to the changes expected. While some projections are based on extrapolations of recent multi-decadal trends, most are based on global climate models (GCMs) that must make assumptions about the range of CO2 emissions and the status of atmospheric greenhouse gas emissions over the next century. Regardless of emission scenarios, it is universally expected that British Columbia will experience warmer air temperatures, coupled with more precipitation in some regions and less in others. Forest fires are expected to be more frequent and more intense in the southern half of the province and in the Taiga Plains, but less important in other portions of the province. Forest insects and fungal pathogens are expected to more fully occupy the current range of their host tree species and expand ranges northward and to higher elevations along with their hosts. More frequent and detrimental pest outbreaks are expected in some regions when several years of favourable weather align. Wind damage, floods, and landslides can be expected to increase on terrain where they are already a risk factor. For many agents of tree mortality, expected changes in disturbance regime amount to an expansion or shifting of the seasonal window of activity, sometimes with different trends projected for different seasons and different regions of the province. The prediction of future forest disturbance regimes is in its infancy, requiring a much more concerted effort in compiling both empirical and simulated data, but managers may wish to adjust plans accordingly where there is largely a consensus among current and projected trends.
Do Audit Data Analytics Influence Juror Perceptions of Audit Quality and Auditor Negligence?
Authors: Barr-Pulliam Dereck , Brown-Liburd Helen L. , Carlson Amanda G. 
Published: November 2022

SUMMARY
We summarize a recent study that examines whether and how the signals provided by the internal control over financial reporting (ICFR) opinion and auditor use of advanced data analytic tools (ADAs) influence juror negligence perceptions. When auditors issue an unqualified ICFR opinion and rely on traditional statistical sampling, jurors assess the auditors as more negligent than when the auditors use ADAs. Conversely, when auditors issue an adverse ICFR opinion, jurors ascribe less blame to auditors and more to investor plaintiffs, regardless of whether the auditors use ADAs. Further, jurors perceive auditors as less negligent when they use ADAs for full population testing because they perceive ADAs to be an indicator of higher audit quality. Interestingly, jurors perceive no difference in the level of assurance provided by the audit opinion alone when auditors use ADAs relative to traditional sampling testing methods.
Macular Complications of Behcet Disease: What to Expect?
Authors: Akioud Wafae , Hamzi Abderrahmane , Khamaily Mehdi , Mozari Yassine , Oubaaz Abdelbarre 
Published: November 2022

Purpose: To determine the rate of incidence and the most common type of macular complications in patients with Behcet disease.

Methods: In this monocentric retrospective clinical study we examined all patients diagnosed with Behcet disease between April 2018 and April 2022 (150 patients). Each individual would undergo a complete ophthalmological examination, a fundus retinography, OCT scan and fluorescein angiography.

Results: 54 patients of 150 presented a macular complication (36%). The macular involvement was bilateral in 49 patients. 60% of patients presented with an initial best corrected visual acuity (BCVA) of equal or less than 1/10. The most common types of maculopathy found in our study was cystoid macular edema (60.4% of patients), macular degeneration (32%), macular hole (5.3%) and serous retinal detachment/epimacular membrane (2.3%).

Conclusion: Macular involvement is very common in Behcet syndrome evolution and is responsible for severe and, most often, irreversible sight loss. Therefore a proper and early management of the disease is mandatory in order to minimize visual impairment.
PENGARUH PENGGUNAAN MEDIA AUDIO VISUAL TERHADAP HASIL BELAJAR MATERI SENI RUPA PESERTA DIDIK KELAS VII DI SMPN 02 RANAH AMPEK HULU TAPAN
Authors: Yunita Putri Okta , Sandra Yofita 
Published: November 2022

Okta Yunita Putri (2020): The Influence of Using Audio Visual Media on Learning Outcomes of Class VII Students in Visual Arts at SMPN 02 Ranah Ampek Hulu Tapan. Thesis Department of Fine Arts, FBS UNP. This research was conducted in order to find out the purpose of the effect of the use of audio visual media on the learning outcomes of class VII students in SMPN 02 Ranah Ampek Hulu Tapan. The method used in this research is quasi-experimental (quasi-experimental) and in this study using a Non Equivalent Control Group Design. The sampling design used was purposive sampling. After all tests are carried out, the Sig value can be obtained. (2-tailed as much as (0.003 <0.005) and the post-test tcount of 3.102, greater than ttable (0.3102> 2,000), then H0 is rejected and H1 is accepted, therefore the learning outcomes of the experimental group are significantly different Compared with the control group, the researcher concluded that the use of Audio Visual media had a positive (good) effect and significantly different on the learning outcomes of students in the learning process of visual art material for class VII at SMPN 02 Ranah Ampek Hulu Tapan.Keywords : Media, Audio Visual, Learning Outcomes, Fine Arts
《詩》《書》古義與金文新證二則
Authors: 鄧 佩玲 
Published: November 2022

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
《詩》、《書》成書甚早，其文辭古雅，歷代學者多有《詩》、《書》難明之嘆。比年以來，考古學發展迅速，出土文獻材料與曰俱增，且多爲先賢所未曾獲睹。二十世紀初，王靜安先生嘗提出著名之“二重證據法”，謂以今日之新發現、新材料、新學問補足、印證，乃至修訂傳世文獻、古籍之記述。從今日新見之青銅器銘文可知，金文用語形式更靈活多變，不拘一格，細審其用詞、用語，實有不少能與《詩》、《書》等先秦古籍參照比觀者，吾人固可藉此契機，將兩者作比觀發明，互補有無。因此，本文以新見金文材料與傳世文獻作相互印證，從而對《詩》“假以溢我”及《書》“乃命寧予以秬鬯二卣”二語之語義內涵作重新探討。
The books Shijing and Shangshu have an early history of formation, and due to its usage of antique wordings and sentence structure, various scholars had expressed great regrets at their difficulties in understanding. In recent years, since the prosperous development in archeology, a huge amount of long-lost documents have been discovered and excavated. In the early 20th century, the reputed scholar Wang Kuo-wei had proposed his famous theory of “dual attestation”, advocating the application of new findings, new materials and new knowledge to supplement, verify or even revise the received documents. As shown by the bronze inscriptions newly found, though their language structures are diverse and unstable, a number of which could also be recognized coherent and consistent with those found in received texts such as Shijing and Shangshu. Taking such critical opportunity, we could surly compare the two for the sake of acquiring a better understanding on their language. Therefore, this paper aims at re-examining the meaning of the phrases "jia yi yi wo" in Shijing and “nai ming ning yu yi ju chang er you” in Shangshu by undertaking a mutual verification between the excavated and the received documents.
傅斯年的史學思想
Authors: 朱 淵清 
Published: November 2022

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
傅斯年是中國近現代思想學街史上著名學者。他創辦史語所開創了中國現代文科學衍。傅斯年提出的“史學即史料學”是一種現代史學的方法理論，提倡以史料為導向進入過去事實，主張史學研究應該從事考證和考古，而免於意識形態和政治關係的干擾。本文論述了傅斯年史學思想的內容和形成，并就傅斯年的科學思想、“史料”概念、歷史學和語言學的關係、考古學以及詮據法五個方面予以解讀分析和理解的批評。
Fu Sinian (1896-1950) was an eminent scholar in early modern Chinese intellectual history. His establishment of the Institute of History and Philology, Academia Sinica, marks the advent of modem liberal arts scholarship. His modern methodology is revealed in his theory that “the study of history is the same as the study of historical sources.” He advocated that historical sources be used as a guide to enter the past world and that the study of history be related to archeology and textology but free from the interference of ideology and politics. The present essay discusses the content and the formation of Fu Sinian’s study of history. The discussion will focus on the interpretation, analysis, comprehension, and critique of five aspects, namely his scientific thought, concept of “historical resources,” the relationship between history and linguistics, archeology, and evidence method.
堅實與脆弱一一析西西的《碗》
Authors: 王 良和 
Published: November 2022

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
本文以文本細讀的方法，結合叙事學的理論，深入分析西西小説《碗》的人物形象、内心世界、隱喻、象徵、意象、性别議題，并探討交叉叙述手法在文中的作用，四段獨白構成怎樣的對話關係；通過多向的分析揭示小説豐富的意涵，并窺探《碗》與小説家西西的關係。
This essay applies close reading to “Bowl”, a novel by Xi Xi, drawing upon narrative theory, to analyze its characterization, the psychology of its characters, and the metaphors, symbols, imagery, and gender issues of the novel. It also explores how the interaction of the four monologues in the novel forms a Bakhtinian dialogue and its significance, in an attempt to unravel the multiple meanings of the work and the relationship between the novel and the novelist.