bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effective and efficient factitious prey for mass production of Neoseiulus cucumeris (Acari: Phytoseiidae): assessing its quality compared with natural prey
Authors: Yazdanpanah Shima , Fathipour Yaghoub , Riahi Elham , Zalucki Myron P. 
Published: February 2022

Abstract
Background
Using alternative diets for the mass production of phytoseiid predatory mites may facilitate their cost-effective rearing. Factitious prey is often used as an alternative food source for mass rearing of generalist phytoseiids. The generalist predator, Neoseiulus cucumeris (Oudemans), is a commercially available biocontrol agent against various pests. We assessed the suitability of two factitious prey, Ephestia kuehniella Zeller eggs and Tyrophagus putrescentiae (Schrank), as diets for long-term rearing (up to 30 generations) of N. cucumeris, when compared with a natural prey, Tetranychus urticae Koch.

Results
The predator completed its development on all tested diets successfully. Under laboratory conditions, Tyrophagus putrescentiae could support the development and oviposition of the predator for up to 30 generations even better than its natural prey T. urticae. However, the eggs of E. kuehniella were not suitable for this predator because of the longer pre-adult period and adults failed to reproduce.

Conclusions
Since rearing on T. putrescentiae for a long time had no adverse effects on the predator’s performance, this factitious prey could be considered as a suitable and cost-effective diet for mass production of N. cucumeris.
Chinese expert recommendations on ketogenic diet therapy for super-refractory status epilepticus
Authors: Tong Xin , Cai Qianyun , Cao Dezhi , Yu Lifei , Sun Dan , Yang Guang , Wang Jiwen , Li Hua , Li Zengning , Wang Juan , Huang Shaoping , Ding Meiping , Fang Fang , Wang Qun , Luo Rong , Liao Jianxiang , Qin Jiong 
Published: February 2022

AbstractSuper-refractory status epilepticus (SRSE) is a serious and life-threatening neurological condition. Ketogenic diet (KD) is a diet characterized by high fat, low carbohydrate, and moderate protein. As KD shows effectiveness in controlling seizures in more than half of SRSE patients, it can be a treatment option for SRSE. Currently, KD treatment for SRSE is based on personal experience and observational evidence has been published. In the context of a lack of a validated guideline, we convened a multicenter expert panel within the China Association Against Epilepsy (CAAE) Ketogenic Diet Commission to work out the Chinese expert recommendations on KD for SRSE. We summarize and discuss the latest clinical practice of KD for SRSE in critical care settings. Recommendations are given on patient selection, the timing of KD, diet implementation, and follow-up. More research data are needed in this area to support better clinical practice.
Bentall surgery and total arch repair with debranching of supra-aortic vessels: a case report
Authors: Victoria-Medina Wilfredo Luna , Quispe-Vizcarra Carlos , Rojas-Huillca Miguel , Moreno-Loaiza Milagros , Cubas W. Samir 
Published: February 2022

Abstract
Background
The surgical approach to pathologies of the Ascending Thoracic Aorta (ATA) that compromise aortic root and the aortic arch is currently one of the most complex interventions in the spectrum of cardiac surgery, where circulatory arrest with cerebral perfusion plays an important role for Success postoperative and patient survival.

Case presentation
We present the case of a 57-year-old patient with the only history of arterial hypertension and an ATA Aneurysm that compromised segment of the aortic root up to segment 2 of the aortic arch. A successful Bentall surgery was performed, debranching supra-aortic vessels with Total Circulatory Arrest with Deep Hypothermic Cerebral Perfusion-Antegrade Bilateral.

Conclusions
With the advent of new anesthetic and neuroprotection techniques, perioperative imaging protocols, advanced hemodynamic monitoring, and invaluable advances in perfusion and Extracorporeal Circulation with circulatory arrest, they have made this surgical challenge a valuable tool for today’s cardiovascular surgeon.
Circulating tumor DNA in cancer diagnosis, monitoring, and prognosis
Authors: Saha Sudeepto , Araf Yusha , Promon Salman Khan 
Published: February 2022

Abstract
Background
Circulating tumor DNA (ctDNA) has become one of the crucial components for cancer detection with the increase of precision medicine practice. ctDNA has great potential as a blood-based biomarker for the detection and treatment of cancer in its early stages. The purpose of this article was to discuss ctDNA and how it can be utilized to detect cancer. The benefits and drawbacks of this cancer detection technology, as well as the field’s future possibilities in various cancer management scenarios, are discussed.

Main text
ctDNA has clinical applications in disease diagnosis and monitoring. It can be used to identify mutations of interest and genetic heterogeneity. Another use of ctDNA is to monitor the effects of therapy by detecting mutation-driven resistance. Different technologies are being used for the detection of ctDNA. Next-generation sequencing, digital PCR, real-time PCR, and mass spectrometry are used. Using dPCR makes it possible to partition and analyze individual target sequences from a complex mixture. Mass-spectrometry technology enables accurate detection and quantification of ctDNA mutations at low frequency. Surface-enhanced Raman spectroscopy (SERS) and UltraSEEK are two systems based on this technology. There is no unified standard for detecting ctDNA as it exists in a low concentration in blood. As there is no defined approach, false positives occur in several methods due to inadequate sensitivities. Techniques used in ctDNA are costly and there is a limitation in clinical settings.

Short conclusion
A detailed investigation is urgently needed to increase the test's accuracy and sensitivity. To find a standard marker for all forms of cancer DNA, more study is needed. Low concentrations of ctDNA in a sample require improved technology to provide the precision that low concentrations of ctDNA in a sample afford.
Role of urinary NAG enzyme in early detection of renal impairment in cystic fibrosis patients
Authors: Osman Hanan Mohsen , Hagras Amal Moustafa , Wilson Manal Michel , Badr Ahmed M. , El Falaki Mona Mostafa , Badawy Ahmed Saad 
Published: February 2022

Abstract
Background
Cystic fibrosis (CF) is the most common life-limiting autosomal recessive disease among people in the USA and Europe with increased prevalence in Egypt. Affected children are in danger of acute kidney injury and the development of chronic renal disease through exposure to multiple nephrotoxic agents. N-acetyl beta-D-glucosaminidase (NAG) is a lysosomal enzyme present in high concentrations in the proximal tubular cells, thus raising urinary NAG levels to reflect tubular dysfunction. The aim of our study is to detect the role of the urinary NAG enzyme in the early detection of renal impairment in CF patients. This cross-sectional study enrolled 40 CF patients diagnosed in the CF Clinic in Children’s Hospital of Cairo University. They were age- and sex-matched to 40 healthy controls. All patients had glomerular filtration rate (GFR), serum creatinine, blood urea nitrogen (BUN), albumin/creatinine (A/C) ratio measured, urine analysis, urinary NAG enzyme using enzyme-linked immunosorbent assay (ELISA), and renal ultrasound (U/S) were done.

Results
Our study showed high levels of urinary NAG in cases with a significant difference between cases and controls (P value < 0.001). There was a significant correlation between urinary NAG enzyme elevation and A/C ratio in urine, nephrotoxic drugs administration, and duration of disease (P value = 0.002, 0.005, 0.019), respectively.

Conclusion
Our study suggested that the NAG enzyme is a good early detector of renal impairment in CF patients before the conventional laboratory assays become deranged.
Vestibular findings in patients with white matter disease
Authors: Hazzaa Nagwa Mohamed , Ahmed Aya Yassin , El-Khair Amany Mohamed Abo , Shafik Noha Ali 
Published: February 2022

Abstract
Background
Older people develop gait and balance dysfunction that is associated with the gradual onset of cerebral white matter disease. White matter disease is easily detected by neuroimaging, whereas small vessels are not; hence, the term small vessel disease is frequently used to describe the parenchyma lesions rather than the underlying small vessel alterations. This study was done to investigate the relationship between the presence and/or absence of white matter disease identified on magnetic resonance imaging with the vestibular findings in elderly patients with dizziness. The current study was conducted on a total number of 30 elderly patients complaining of dizziness and/or instability. The inclusion criteria are patients above 55 years old and a history of vertigo and/or instability. All the study groups were subjected to full neuro-otological history, hearing assessment, video-nystagmography test (VNG), assessment of the risk of fall by functional gait assessment test (FGA), and radiological assessment: magnetic resonance stroke protocol.

Results
FGA total scores were significantly lower in patients with white matter disease (0.047) specifically PVWM score 3 (0.04) and DWM score 3 (0.19). Abnormal VNG test results were significantly higher in patients with atherosclerotic changes (0.04). The most common VNG finding abnormality was positional nystagmus.

Conclusions
Normal VNG findings in elderly dizzy patients should be complemented with FGA test to assess the risk of falls. The presence of risk factors for white matter disease (WMD) as hypertension, diabetes mellitus, ischemic heart disease, hyperlipidemia, and migraine is an indication for requesting a further radiological assessment. The most frequent VNG abnormality in elderly patients with white matter disease is positional and positioning nystagmus, and a significant number of patients had positional nystagmus of the non-localizing criteria. FGA test scores are significantly related to the severity of white matter disease. The presence of atherosclerotic changes is significantly related to the presence of VNG test abnormality. It is important to ask the patient about the past history of migraine as it has an effect on VNG, FGA, and radiological findings.
Thyroid and Breast Cancer in 2 Sisters With Monoallelic Mutations in the Ataxia Telangiectasia Mutated (ATM) Gene
Authors: Miasaki Fabíola Y , Saito Kelly C , Yamamoto Guilherme L , Boguszewski César L , de Carvalho Gisah A , Kimura Edna T , Kopp Peter A 
Published: February 2022

Abstract
The presence of a bidirectional risk for metachronous carcinomas among women with thyroid and breast cancer is well established. However, the underlying risk factors remain poorly understood.
Two sisters developed papillary thyroid cancer (PTC) at age 32 and 34 years, followed by ductal carcinoma of the breast at 44 and 42 years. The 2 children of the younger sister developed ataxia-telangiectasia; the son also developed lymphoblastic lymphoma and his sister died secondary to acute lymphoblastic leukemia (ALL). They were found to be compound heterozygous for ataxia telangiectasia mutated (ATM) gene mutations (c.3848T&gt;C, p.L1283P; and c.802C&gt;T, p.Q268X). Exome sequencing of the 2 sisters (mother and aunt of the children with ataxia-telangiectasia) led to the detection of the pathogenic monoallelic ATM mutation in both of them (c.3848T&gt;C; minor allele frequency [MAF] &lt; 0.01) but detected no other variants known to confer a risk for PTC or breast cancer.
The findings suggest that monoallelic ATM mutations, presumably in conjunction with additional genetic and/or nongenetic factors, can confer a risk for developing PTC and breast cancer.
Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
Authors: Markl-Hahn Hülya , Neugebauer Leon , Lenke Livia , Ecker Sarah , Merz Tamara , McCook Oscar , Khoder Noura , Brucker Cosima , Radermacher Peter , Waller Christiane , Clapp Carmen , Bertsch Thomas , Triebel Jakob 
Published: February 2022

Abstract
Hormonal factors affecting the vascular adaptions of the uteroplacental unit in noncomplicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia (PE) were investigated for the presence of placental lactogen (PL)-derived, antiangiogenic vasoinhibin. Western blotting and mass spectrometry of placental tissue revealed the presence of a 9-kDa PL-derived vasoinhibin, the normal 22-kDa full-length PL, and a 28-kDa immunoreactive protein of undetermined nature. The sequence of the 9-kDa vasoinhibin includes the antiangiogenic determinant of vasoinhibin and could constitute a relevant factor in normal pregnancy and PE.
Subversive Habits
Authors: Williams Shannen Dee 
Published: February 2022

In Subversive Habits, Shannen Dee Williams provides the first full history of Black Catholic nuns in the United States, hailing them as the forgotten prophets of Catholicism and democracy. Drawing on oral histories and previously sealed Church records, Williams demonstrates how master narratives of women’s religious life and Catholic commitments to racial and gender justice fundamentally change when the lives and experiences of African American nuns are taken seriously. For Black Catholic women and girls, embracing the celibate religious state constituted a radical act of resistance to white supremacy and the sexual terrorism built into chattel slavery and segregation. Williams shows how Black sisters—such as Sister Mary Antona Ebo, who was the only Black member of the inaugural delegation of Catholic sisters to travel to Selma, Alabama, and join the Black voting rights marches of 1965—were pioneering religious leaders, educators, healthcare professionals, desegregation foot soldiers, Black Power activists, and womanist theologians. In the process, Williams calls attention to Catholic women’s religious life as a stronghold of white supremacy and racial segregation—and thus an important battleground in the long African American freedom struggle.
A low-cost otoscopy simulator increased confidence in mechanical otoscopy skills and tympanic membrane pathology identification among preclinical medical students during the COVID-19 pandemic
Authors: Patel Shiv H , Soliman Shady I , Suresh Preetham , Goldberg Charles , Wooten Darcy 
Published: February 2022

Background: Diagnostic evaluation of otologic diseases often requires otoscopy to visualize the tympanic membrane. The fundamentals of otoscopy include both learning the mechanics of using an otoscope and accurately identifying ear pathologies. During the COVID-19 pandemic, there was limited peer-to-peer physical exam practice for preclinical medical students. We developed a low-cost 3D-printed otoscopy simulator to teach the otoscopic exam to small groups of medical students. Methods: A modified open-source 3-dimensional (3D) head was printed, and a silicone ear was attached. A user interface was created to display one normal tympanic membrane and four pathologies. Preclinical medical students attended a didactic lecture on common otologic pathologies and on how to perform otoscopy. Students then practiced otoscopy and pathology identification on the simulator in small groups. After the session, students were provided an optional survey to evaluate their confidence in otoscopy skills and pathology identification. Results: A total of 47 out of 134 (35%) medical students completed the survey, of whom 60% reported that training with the 3D printed otoscopy simulator was at least moderately effective in learning the mechanical techniques of otoscopy, and 66% found the simulator to be at least moderately effective in helping them learn to identify pathology. The majority (57%) of students reported that the otoscopy simulator was more effective than practicing otoscopy on their peers. Conclusions: We demonstrate the utility of a novel low-cost 3D printed otoscopy simulator to teach both the mechanical skills and pathology identification necessary in performing an otoscopic exam to preclinical medical students.
New Erodibility Parameterization for Applying WEPP on Rangelands Using ERMiT
Authors: Al-Hamdan Osama Zuhair , Pierson Fred B. , Robichaud Peter , Elliot William J. , Williams Christopher Jason 
Published: February 2022

HighlightsA practical parameterization approach to estimate erodibility was developed for WEPP applications on rangelands.Soil texture had a greater effect on rill erodibility than vegetation cover.Vegetation cover had a greater effect on interrill erodibility than soil texture.A new set of erodibility input parameters was defined for ERMiT applications on rangelands.Abstract. The USDA Water Erosion Prediction Project (WEPP) is a process-based soil erosion prediction model. WEPP uses three soil erodibility parameters: rill erodibility (Kr), interrill erodibility (Ki), and critical hydraulic shear stress (tc). In this study, a new parameterization approach for estimating erodibility was developed for WEPP applications on rangelands. Data from overland flow experiments on disturbed and undisturbed rangelands were used to develop empirical equations to predict rill erodibility variation as a function of vegetation cover and soil texture. Data from rainfall simulation experiments were analyzed by piecewise regression to develop empirical equations for predicting the variability of interrill erodibility before and after disturbance and across a wide range of soil textures as a function of vegetation cover and soil texture. Critical shear values corresponding to the developed rill and interrill erodibility parameters were proposed. Our results show that the new erodibility approach predicts erosion at the plot scale with a satisfactory range of error (PBIAS =35.6 and Nash-Sutcliffe efficiency = 0.49). The new approach was used to provide soil erodibility values for the Erosion Risk Management Tool (ERMiT), which uses WEPP as the runoff and erosion calculation engine. Keywords: ERMiT, Erosion, Interrill, Rangeland management, Rill, Shrub, Soil burn severity, WEPP.
Bioinspired Imbricated Microthorn Scale Surfaces and their Abrasive Wear Performance
Authors: Zhang Zhihong , Yuan Shuo , Lai Qinghui , Zuo Guobiao , Guler Huseyin 
Published: February 2022

HighlightsImproving the wear resistance of soil-engaging components is an urgent need for the agricultural machinery industry.Sandfish (Scincus scincus) epidermis with exceptional wear resistance was selected as a bionic prototype.By adopting a bionic engineering approach, a novel bioinspired microthorn scale surface was designed and prepared.Numerical simulations were performed with EDEM to investigate the wear resistance mechanism.Abstract. To solve the problem of abrasive wear failure of the soil-engaging components of agricultural machinery, the imbricated microthorn scale structure of the sandfish (Scincus scincus) epidermis surface was selected as a bionic prototype. By adopting a bionic engineering approach, nine bionic microthorn scale surface specimens with different geometric structure parameters were designed and prepared. Wear resistance tests were performed in a rotating abrasive wear testing system. The results of the wear tests showed that the imbricated microthorn scale structured surfaces had substantially less abrasion loss than a conventional smooth surface. The influence of the geometric structure parameters on the wear performance was also identified. Numerical simulations were performed to explore the wear resistance mechanism of the imbricated microthorn scale structured surfaces. The abrasion of the bionic surfaces mainly occurred at the edge of the microthorn that faced the abrasive particle flow. The trajectory of subsequent abrasive particle flow was modified by the large dispersion of particle flow; hence, the number of particles that impacted the surface decreased. Therefore, the wear resistance performance of the bionic surfaces was enhanced. This bioinspired surface can provide a technical reference to mitigate the abrasive wear failure of the soil-engaging components of agricultural machinery. Keywords: Abrasive wear, Archard wear, Bionic design, Discrete element method, Scale surface.
Risks for development of metabolic disorders in alimentary constitutional obesity
Authors: Lyasnikova M. B. , Belyakova N. A. , Tsvetkova I. G. , Rodionov A. A. , Milaya N. O. 
Published: February 2022

BACKGROUND: alimentary-constitutional obesity due to it’s high prevalence, is the key problem of modern healthcare system. However, obesity is not always accompanied with metabolic disorders, leading to early invalidization and mortality. That’s why it is important to study risks of metabolical nonhealth in obesity.AIM: to detect factors, increasing risks of development of metabolic disbalance in alimentary-constitutional obesity.MATERIALS AND METHODS: In patients with alimentary-constitutional obesity there was performed an examination including anthropometry (body mass index, Waist Circumference, Hip Circumference,waist to hip ratio), blood pressure measurement, laboratory tests – metabolic indexes: glucose, insulin, insulin resistance indexes, leptin, cholesterol, cholesterol of lipoproteins, triglycerides, aspartate aminotransferase, alanine aminotransferase, gamma-glutamiltransferase), body composition measurement by bioelectrical impedance analysis; patients were also interviewed on their behavior (food habits) and physical activity.RESULTS: There were formed two groups depending on metabolic health indexes: main group – metabolically non-healthy obesity (MNHO) - 241 persons (aged 41±12,09, duration of obesity 12,5±9,51 years) with alimentary-constitutional obesity and two or more signs of MS, a comparison group – of metabolically healthy obesity (MHO) – 120 persons (aged 35,5±10,03; p<0,05, duration of obesity 8,0±7,39 years; p<0,05) with alimentary-constitutional obesity and one sign of MS or without it. Data analysis of studied risk factors for development of metabolically non-healthy alimentary-constitutional obesity confirmed that most relevant factor in development of MNHO is abdominal fat mass distribution (increasing of Waist Circumference over 88 sm in females and over 102 sm in mails). At the same time MNHO had correlation not only with classical signs of MS, but also with blood insulin level, insulin resistance indexes, fat metabolism disbalance and liver disfunction. More severed risk for appearance of metabolic disorders have patients over 45 years old with decreased active cell mass (less than 45%), duration of obesity above 10 years and obesity-burdened heredity. In food habits risk of development of metabolically non-healthy obesity was increased in taking of fat milk food, and, on the contrary, - frequent snacks, alcohol free sweet drinks didn’t affect it.CONCLUSION: Development of MNHO is associated not only with the age of patient, duration of obesity, carbohydrate and fat metabolism indexes, but also with decreased percentage of metabolically active tissues and some food habits.