bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Analysis of Factor that Associated the Antenatal Care (ANC) Visit in Pregnant Woman during the COVID-19 Pandemic at Blooto Health Center, Mojokerto
Authors: Nurfitriyani Bella Ayu , Puspitasari Novia Indah 
Published: June 2022

Background: The COVID-19 pandemic situation has harmed various sectors. Maternal and child health services are also affected in terms of access and quality. Based on the health profile of Mojokerto City in 2021, Blooto Health Center has the highest K1 (100.7%) and K4 (98.1%) coverage in 2020 compared to other health centers in Mojokerto City. In 2021 in the first quarter of K1 coverage decreased compared to 2020. In January 2020 and 2021, it was 10% and 8.63%, February 2020 and 2021 were 19% and 17.79%, and March 2020 and 2021 were 29, 4%, and 28.3%.
Objectives: This study aims to analyze what factors are associated with Antenatal Care (ANC) visits to pregnant women during the COVID-19 pandemic in the work area of the Blooto Health Center, Mojokerto City.
Methods: This study used a cross-sectional research design. The research population was 182 pregnant women with a sample of 79 pregnant women. The sampling technique is simple random sampling. The independent variables of the study were education level, employment status, disease history, age, parity, knowledge, attitude, application of health protocols, distance from residence to health facilities, the role of medical personnel, and availability of health protocol facilities at health care facilities. The dependent variable of the study was antenatal visits. Primary data collection using online questionnaires and secondary data, namely the maternal cohort book. Data analysis used univariable and bivariable analysis by calculating the Prevalence Ratio (PR) value.
Results: There is a relationship between education level, knowledge, attitude, application of health protocols, the distance of residence, role of medical personnel, and availability of health protocol facilities with ANC visits during the COVID-19 pandemic. Meanwhile, age, employment status, disease history, and parity were not related to ANC visits during the COVID-19 pandemic.
Conclusions: Education level, knowledge, attitude, application of health protocols, the distance of residence, role of medical personnel, and availability of health protocol facilities related to ANC visits during the COVID-19 pandemic. Health workers and community leaders are expected to provide education to pregnant women on the importance of doing ANC checks and apply health protocols during the pandemic.
The Relationship between Social Support and Vaping Behavior of Senior High Age Adolescents in Surabaya
Authors: Damarjati Blasius Hasni , Widati Sri 
Published: June 2022

Background: Smoking has a negative impact on health in people of all ages, especially adolescents. With technological advancements, cigarettes have taken on a new form: e-cigarettes. The US Food and Drug Administration (FDA) has begun to prohibit the use of e-cigarettes because they contain hazardous and carcinogenic tobacco specific nitrosamines and diethylene glycol (DEG). However, e-cigarettes are becoming increasingly popular in Indonesia, with an increasing number of users.
Objectives: To investigate the relationship between social support on smoking/vaping behaviors of senior high age adolescents in Surabaya.
Methods: This is a quantitative study with a cross-sectional and observational analytic design. The total number of respondents in this study was 145, as determined by the snowball sampling method. The independent variable is social support. Social support consists of instrumental support, informational support, emotional support, and appraisal support. The behavior of smoking/vaping is the dependent variable.
Results: The relationship among variables was measured by using Pearson Chi-Square Test. The result shows that there is a relationship of instrumental support (p=0.000), informational support (0.019), emotional support (p=0.000), and appraisal support (p=0.000) on smoking / vaping behavior in senior high age adolescents.
Conclusions: There is a relationship between social support and smoking / vaping behavior of high school age adolescents in Surabaya. Social support is important since it can influence the adolescents smoking behavior. It is hoped the family such as parents can provide a better understanding of the effect of smoking on health and for adolescents should be more selective with whom they hang out with and have the courage to refuse a friend's invitation to smoke.
Prevention Factors For Toddlers Below The Red Line In Surabaya
Authors: Widyanti Fitri 
Published: June 2022

Background: Toddlers with BGM (Below the Red Line) are children whose weight for age (BW / U) is below the red line on the KMS, thus indicating malnutrition status. BGM toddlers can be used as an early indicator that the toddler is experiencing nutritional problems that need to be addressed immediately. Objectives: This study analyzes the problems / symptoms and preventive measures for children under the red line in the Wonokusumo Health Center in Surabaya. Methods: This research is an analytic observational study, with a cross sectional design. Subjects were taken by simple random sampling. The population of this research is mothers who have toddlers aged 12-24 months who live in the working area of the Wonokusumo Health Center in Surabaya. The independent variables used are perceived vulnerability, perceived severity, perceived benefits, perceived obstacles, and cues to take action, while the dependent variable used was maternal BGM prevention behavior.Results: This study resulted in several conclusions, namely that there is a relationship between the perceived vulnerability of respondents to taking preventive measures for BGM under five; there is a relationship between the severity felt by the respondents on the prevention measures for BGM under five; there is no relationship between the benefits felt by the respondents on the prevention measures for children under five BGM; there is no relationship between the obstacles felt by respondents to the prevention measures for BGM under five; and there was no relationship between cues to act on precautions for BGM under five.Conclusions: This study views the importance of monitoring the growth of children under five at the posyandu and providing PMT to prevent BGM from under five.
Pola Kepemilikan Sumber Air Minum Rumah Tangga di Jawa Timur
Authors: Lestari Novi , Indriani Diah 
Published: June 2022

ABSTRAKLatar Belakang: Konsumsi air yang layak merupakan salah satu faktor untuk mencegah terjadinya masalah kesehatan seperti diare, kolera, disentri, tipes, cacingan, penyakit kulit, dan keracunan.. Diare menjadi penyebab kedua kematian tertinggi pada balita di seluruh dunia. masih ada beberapa daerah di Indonesia yang mengalami kekurangan air bersih dan air yang tercemar berat.Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kepemilikan sumber air minum dan pengolahan air minum sebelum diminum dengan jenis wilayah tempat tinggal di Provinsi Jawa Timur berdasarkan data SDKI tahun 2017.Metode: Penelitian ini menggunakan data dari Survei Demografi dan Kesehatan Indonesia tahun 2017 di wilayah Jawa Timur dengan desain cross sectional. Jumlah sampel yang digunakan adalah 4113 rumah tangga. Data yang diperoleh berasal dari situs resmi DHS. Analisis yang digunakan pada penelitian ini adalah analisis Chi Square.Hasil: Hasil penelitian didapatkan adanya hubungan yang signifikan sumber air minum dan pengolahan air minum sebelum diminum dengan jenis wilayah tempat tinggal (p < 0,05). Sumber air minum dan pengolahan air minum memiliki korelasi dengan jenis wilayah tempat tinggal. Prevalensi rasio sumber air minum adalah 0,355 dan pengolahan air minum adalah 3,321.Kesimpulan: Rumah tangga di perkotaan mayoritas memiliki sumber air minum yang layak serta rumah tangga di perkotaan cenderung mengonsumsi air kemasan untuk minum. Rumah tangga di pedesaan melakukan pengolahan air minum sebelum dikonsumsi. ABSTRACTBackground: Adequate water consumption is one of the factors to prevent health problems such as diarrhea, cholera, dysentery, typhoid, intestinal worms, skin diseases, and poisoning. Diarrhea is the second highest cause of death in children under five in the world. There are still some areas in Indonesia that experience a shortage of clean water and heavily polluted water.Objectives: This study aims to determine the relationship between ownership of drinking water sources and treatment of drinking water before drinking with the type of area of residence in East Java Province based on the 2017 IDHS data.Methods: This study uses data from the 2017 Indonesian Demographic and Health Survey in the Java region. East withdesign cross sectional. The number of samples used is 4113 households. The data obtained comes from the official website of DHS. The analysis used in this study is Chi Square analysis.Results: The results of the study found a significant relationship between drinking water sources and drinking water treatment before drinking with the type of area of residence (p < 0,05). Drinking water sources and drinking water treatment have a correlation with the type of area of residence. The prevalence ratio of drinking water sources is 0,355 and drinking water treatment is 3,321.Conclusions:. The majority of households in urban areas have a decent source of drinking water and households in urban areas tend to consume bottled water for drinking. Households in rural areas treat drinking water before consumption.
Increasing Assertive Behavior in Adolescents in Islamic Boarding Schools Through Assertive Training
Authors: Nuris Yuhbaba Zidni , Arif Budiman M.Elyas , Sholihah Erdah Suswati Wahyi , Wirasakti Guruh 
Published: June 2022

Introduction: Assertive behavior is the ability to communicate the individual's want, feel, and think to others honestly and openly while respecting personal and other people's rights. One way to increase assertiveness in adolescents is through assertive training activities where this activity presents systematic activities that can develop and train individuals' abilities to express their thoughts, feelings, desires, and needs confidently. The purpose of this study was to analyze the change in assertive behavior of adolescents living in Islamic boarding schools through assertive training.Method: This was pre-experimental research with pre-post design. The sample was 80 respondents which were obtained by the purposive sampling technique. The measuring instrument uses assertive behavior questionnaires and data analysis using the Wilcoxon Paired testResults: The results of the analysis of assertive behavior in adolescents before the intervention were in a low category (42.5%) and after the intervention, adolescent assertive behavior was in a good category (46.3%). The results showed a p-value of 000 which is result indicated that there was an increase in the assertive behavior of adolescents living in Islamic boarding schools through assertive training.Conclusions: Adolescents with high assertiveness are able to control their emotions, mental health and have good coping with solving personal and social problems, and are able to express their wishes firmly to others
Giant aneurysm of left circumflex artery branch with fistula to the coronary sinus: a case report
Authors: Toyoda Yasuyuki , Takemura Takahiro , Shiratori Kazuaki , Yazaki Yoshikazu , Tachibana Takahiro , Niitsu Hirokazu , Kunihara Takashi 
Published: June 2022

Abstract
Background: Aneurysm of a coronary artery branch with a fistula is extremely rare. Here, we present a case of giant aneurysm of the left circumflex artery branch with a fistula to the coronary sinus treated successfully with aneurysmectomy.Case presentation: A 58-year-old woman was referred to our hospital due to an abnormal pericardial mass found by multidetector computed tomography. Imaging examination revealed a dilated left circumflex artery branch with a 30-mm aneurysm. Coronary angiography confirmed a left circumflex artery branch aneurysm with a fistula to the coronary sinus. As percutaneous occlusion of the aneurysm by catheterization was considered unsuccessful, the aneurysm was resected and the fistula was occluded surgically with excellent outcome. Pathological examination suggested that congenital factors may have contributed to the development of the aneurysm. Computed tomography showed no recurrence of the aneurysm at 1-year postoperative follow-up.Conclusions: We presented a case of giant aneurysm of the left circumflex artery branch with a fistula to the coronary sinus. This is the first report of the combination of a giant coronary artery branch aneurysm with a fistula to the coronary sinus. Surgical aneurysmectomy should be considered in such cases to avoid fatal aneurysmal complications.
Stimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson’s Electronically (STRIPE trial): a randomised control trial of tibial nerve stimulation for bladder symptoms in Parkinson’s disease using a self-contained wearable device
Authors: Smith Matthew , Tenison Emma , Drake Marcus J , Ben-Shlomo Yoav , Henderson Emily J 
Published: June 2022

Abstract
Background: Bladder symptoms are common in Parkinson’s disease (PD), affecting half of all individuals. These have significant impact on quality of life as well implications for morbidity, contributing to falls and hospital admission. The treatment of bladder symptoms can be complicated by the tendency to side-effects in people with PD including cognitive impairment and gait instability with anti-muscarinics. The development of new, better treatments is therefore warranted. Tibial nerve stimulation is a form of neuromodulation demonstrated to improve overactive bladder symptoms in non-neurogenic cohorts. Previously requiring hospital attendance, we aim to explore the use of this intervention using a simple device that can be used by patients at home. Methods: STRIPE is a phase II randomised control trial of tibial nerve stimulation delivered by the Geko™ device, a small, self-adhesive neuromuscular stimulation device currently used for thromboembolism prophylaxis post-surgery. Active tibial nerve stimulation will be compared to sham stimulation, with participants blinded to treatment allocation and undertaking outcome assessment whilst still blinded. Participants will be asked to self administer stimulation at home twice per week, for 30 minutes per session, over the course of three months. Primary outcome measure will be the International Consultation on Incontinence Overactive Bladder Questionnaire (OAB) at week 12. Secondary outcomes will include pre and post intervention bladder diary (frequency, urgency episodes, nocturia), patient perception of global change, bowel function and bladder related quality of life. Participants will be recruited from the Proactive Integrated Management and Experience (PRIME) cross-sectional trial in which participants have been screened for bladder symptoms and invited to take part, as well as clinician referral from around the region. Discussion: This trial will involve a randomised control trial of a novel and easy to use method of delivering tibial nerve stimulation for PD in the patient’s own home. This may potentially have huge benefit, avoiding the problems with side effects that can be seen with anti-muscarinics and providing a new potential modality of treatment. Trial registration: This trial was prospectively registered on the ISRCTN registry on 22/06/21 (11484954)
The effects of a three-day mountain bike cycling race on the autonomic nervous system (ANS) and heart rate variability in amateur cyclists
Authors: Swart Anton 
Published: June 2022

Abstract
Objectives
Increased endurance exercise may cause an acute reduction in cardiac function, causing a physiological cascade. Heart rate variability (HRV) is a physiological measurement used to evaluate the autonomic nervous system (ANS) state. This study set out to determine the changes in the ANS by participating in a three-day mountain bike cycling event using HRV as an outcome measure.
Methods
Sixteen healthy participants (male and female) participating in a three-day mountain bike cycling event underwent five-minute resting electrocardiography (ECG) recordings in a supine position. In addition, heart rate variability measurements were recorded two days before the race (baseline testing), after each race day, and 24-hours post-event (recovery).
Results
Time-domain and frequency domain measures showed significant changes from baseline HRV parameters after each race day (p ≤ 0.05). In addition, our data revealed that the mean heart rate (HR) and R-R variability intervals did not return to baseline values after 24-hours of recovery. Thus, reflecting autonomic nervous system (ANS) dysfunction due to increased sympathetic activity and parasympathetic withdrawal.
Conclusions
The main strength of this study is using HRV as a measuring and screening tool to assess cardiac autonomic activity, whereby the state of the ANS before and after endurance events can be measured. Thus, physicians, athletes, and coaches can assess the stress of endurance events on the ANS and plan for correct recovery strategies. The reasoning is that if the ANS is in a state of dysfunction, susceptible amateur athletes might be at risk for a cardiovascular event.
Tumour evolvability metrics predict recurrence beyond 10 years in locally-advanced prostate cancer
Authors: Fernandez-Mateos Javier , Cresswell George , Trahearn Nicholas , Webb Katharine , Stuttle Christine , Corbishley Catherine , Starvrinides Vasilis , Zapata Luis , Spiteri Inma , Heide Timon , Gallagher Lewis , James Chela , Gao Annie , Kote-Jarai Zsofia , Acar Ahmet , Truelove Lesley , Proszek Paula , Murray Julia , Reid Alison , Wilkins Anna , Hubank Michael , Eeles Rosalind , Dearnaley David , Sottoriva Andrea 
Published: June 2022

Abstract

Cancers evolve obeying Darwinian laws and therefore the evolutionary paradigm lays the ground for predictive oncology. However, the predictive power of evolutionary metrics in cancer has been seldom tested. There is a need for quantitative measurements in controlled clinical trials with long term follow-up information. This is particularly true in locally-advanced prostate cancer, which can recur more than a decade after diagnosis. Here we mapped genomic intra-tumour heterogeneity in 642 samples from 114 patients who took part in the prostate radiotherapy trials at The Royal Marsden Hospital, for which full clinical information and 12y median follow-up was available. We concomitantly assessed phenotypic (morphological) heterogeneity using deep learning in 1,923 histological sections from 250 IMRT patients (fully overlapping with the genetic set). We found that evolvability, measured as genetic divergence as well as morphological diversity, was a strong independent predictor of recurrence (respectively HR=72.06, 95% CI 2.97-1748.5, p=0.009 and HR=6.2, 95% CI 1.86-20.72, p=0.003). Combined, these two measurements together also identified a group of patients with half the median time to recurrence compared to the rest of the cohort (5.6 vs 11.5 years). We also found a small subset of MYC/FGFR1 amplified cases (4.4%) with particularly poor prognosis. The overall burden of chromosomal alterations correlated with higher Gleason score. We identified associations between 24 chromosomal arm copy number changes and Gleason score (e.g. -22q, +5p, +8q, +16p, +7p), and show that loss of chromosome 6p (encompassing the HLA locus) was correlated with markedly reduced immune cell infiltration. This study shows that combining genomics with AI-aided histopathology in clinical trials leads to the identification of novel clinical biomarkers.
A cost of illness comparison between clinical judgement and molecular point-of-care testing for influenza-like-illness patients in primary care in Germany
Authors: Sauerland Dirk , Brachmann Matthias , Serwa Paulina 
Published: June 2022

Abstract
Seasonal influenza poses a serious public health problem causing a high economic burden for the society (1). An early diagnosis supported by routine use of rapid influenza tests is likely to reduce overall costs in cases of suspected infection (2). It is associated with a constraint in the spread of the disease and a reduced risk of extra diagnostics and hospitalization (3,4,5). However, rapid diagnostic tests have not yet been integrated into a routine use in German primary care. Here we show that the point-of-care testing may produce lower costs of illness than relying on clinical judgement alone. We developed a decision tree model to simulate costs of illness for a hypothetical cohort of influenza like illness (ILI) patients in primary care with different diagnostic approaches: clinical judgement with no technical support and point of care testing. The cost calculating model includes direct costs of illness from a payor perspective and is calculated for age groups of elderly, adults and children. The costs of illness for ILI patients are lower by 7.05 € per patient when comparing the POCT pathway to clinical judgement alone. On a national level this could mean lower costs of 64,195,730 € when calculated for a peak influenza season. The costs of illness as well as their difference varies widely among the age groups. Using clinical judgement alone the costs of illness sum up to 155.99 € for the elderly (aged 60+) compared to 76.31 € for adults and 74.15 € for children. With POCT the costs of illness for the elderly amount 115,09 € which is 26% lower than the costs without diagnostic support. The costs for adults and children are 74.42 € and 75.66 € which means lower costs of illness of 2.5% for adults and higher costs of 2% for children. Our results demonstrate that the use of POC testing to support primary care physicians in detecting influenza in influenza-like-illness patients may reduce overall cost of illness in Germany. This is most significant when used for elderly patients. Provided data can help governments to make informed decisions about potential costs savings by integrating POCT into the reimbursement scheme.
Detecting Stochastic Governing Laws with Observation on Stationary Distributions ∗
Authors: Chen Xiaoli , Wang Hui , Duan Jinqiao 
Published: June 2022

Abstract
Mathematical models for complex systems are often accompanied with uncertainties. The goal of this paper is to extract a stochastic differential equation governing model with observation on stationary probability distributions. We develop a neural network framework to learn the drift and diffusion terms of the stochastic differential equation. We introduce a new loss function containing the Hellinger distance between the observation data and the learned stationary probability density function. After minimizing this loss function in the training procedure, we find that the learned stochastic differential equation shows a reasonable approximation of the data-driven dynamical system. The effectiveness of our framework is demonstrated in numerical experiments.