bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of advanced ovarian cancer with carboplatin and paclitaxel in a patient undergoing hemodialysis: Case report and literature review
Authors: Yang Qing , Han Enhong , Xu Shanshan , Xu Yongxing , Gao Jianjun 
Published: May 2022

AbstractA 69‐year‐old woman under maintenance hemodialysis was diagnosed with advanced ovarian cancer. We treated the patient with combination chemotherapy using paclitaxel and carboplatin. She experienced grade 4 thrombopenia on day 8 of the third course. The area under the concentration versus time curve (AUC) of platinum was 3.5 mg/ml·min. The interval between chemotherapy and hemodialysis was shortened starting with the fourth course. The AUC of platinum was then found to be 1.8 mg/ml·min. After seven courses of chemotherapy, the patient's CA 125 serum level dropped from 1317 to 42.6 U/ml. Nevertheless, the patient presented with long periods of severe myelosuppression. In patients on hemodialysis receiving such chemotherapy, the AUC of each cycle should be closely monitored and the dialysis schedule should be adjusted as need to reduce the risk of bone marrow suppression.
THE NEUTRALITY OF NOMINAL RATES: HOW LONG IS THE LONG RUN?
Authors: Valle e Azevedo João , Ritto João , Teles Pedro 
Published: May 2022

AbstractWe revisit the empirical relationship between policy interest rates and inflation aimed at understanding the reasons for persistently low inflation in Japan and the euro area and why monetary policy has been unable to raise it. We document the long‐run positive relationship between nominal rates and inflation across countries and across time. We also find that a permanent rise in nominal rates leads to an increase in inflation, also in the short run. These findings suggest that the low inflation outcomes are a result of policy rates being kept too low for too long.
The influence of Chinese herbal medicines on cancer‐related pressure ulcer wound, fatigue, constipation, and anorexia: A meta‐analysis
Authors: Li Han , Liu Huan 
Published: May 2022

AbstractWe performed a meta‐analysis to evaluate the influence of Chinese herbal medicines on cancer‐related pressure ulcer wounds, fatigue, constipation, and anorexia. A systematic literature search up to March 2022 was done and 25 studies included 1777 subjects with cancer‐related symptoms at the start of the study; 953 of them were provided with Chinese herbal medicines and 824 were control. They were reporting relationships about the influence of Chinese herbal medicines on cancer‐related pressure ulcer wounds, fatigue, constipation, and anorexia. We calculated the odds ratio (OR) with 95% confidence intervals (CIs) to assess the influence of Chinese herbal medicines on cancer‐related pressure ulcer wounds, fatigue, constipation, and anorexia using the dichotomous method with a random or fixed‐effect model. Chinese herbal medicines had significantly higher effectiveness in treating pressure ulcer wound (OR, 5.94; 95% CI, 3.94‐8.95, P < .001), fatigue (OR, 2.81; 95% CI, 1.78‐4.41, P < .001), and effectiveness on treating constipation (OR, 2.59; 95% CI, 1.57‐4.25, P < .001) compared to control in subjects with cancer‐related symptoms. However, Chinese herbal medicines had no significant effect on treating anorexia (OR, 1.69; 95% CI, 0.61‐4.66, P = .31) compared to control in subjects with cancer‐related symptoms. Chinese herbal medicines had significantly higher effectiveness in treating pressure ulcer wound, treating pressure ulcer wound, fatigue, and constipation compared to control in subjects with cancer‐related symptoms. However, Chinese herbal medicines had no significant effect on the effectiveness of treating anorexia compared to control in subjects with cancer‐related symptoms. Further studies are required to validate these findings.
The market value of decomposed carbon emissions
Authors: Ott Christian , Schiemann Frank 
Published: May 2022

AbstractWe introduce the decomposition of carbon emissions into an expected and an unexpected component and analyze the association between these components and firm value. The expected component captures a firm's average carbon emissions inherent to its business model and operating environment. The unexpected component, meaning the firm‐specific deviation from expected carbon emissions, reflects the management's effort and ability to implement carbon management and actively influence carbon emissions. For a sample of US firms operating in carbon‐intensive industries, we estimate the expected component using a regression of carbon emissions on firm characteristics and industry. The residual of this regression represents the unexpected component. The results reveal that, on average, investors attach value to both components. While investors consider the expected component to be relevant regardless of assurance, they consider the unexpected component to be more relevant in the presence of assurance. The assurance alleviates credibility concerns about the information content of the unexpected component. Additionally, we confirm the nomological validity of our measure of the unexpected component, as it is negatively related to indicators of better carbon management systems.
Cross‐border mergers and acquisitions and corporate social responsibility: Evidence from Chinese listed firms
Authors: Li Zhe , Wang Ping 
Published: May 2022

AbstractThis study examines the impact of cross‐border mergers and acquisitions (M&As) on acquirers’ corporate social responsibility (CSR). Based on a sample of Chinese listed firms, we find that firms with cross‐border M&A activities experience an improvement in subsequent CSR performance. Specifically, the CSR rating is approximately 8.24% higher in firms with cross‐border M&As than in those without such activities. We also find that this positive influence is more pronounced in firms with low initial CSR ratings than in those with high initial CSR ratings at the time when a cross‐border M&A deal is completed. Additional analyses reveal that this positive effect is mainly driven by the target firms from countries with high social preference relative to China and that the enhancement in CSR driven by cross‐border M&As translates into higher operating performance and easier access to finance. Overall, our findings demonstrate that cross‐border M&As can serve as a critical channel for acquirers from a country with low institutional quality to build a better reputation through environmentally friendly behaviour and socially responsible engagement, and therefore gain capital market benefits.
A database of the morphology, ecology and literature of the world's limb‐reduced skinks
Authors: Camaiti Marco , Evans Alistair R. , Hipsley Christy A. , Hutchinson Mark N. , Meiri Shai , Anderson Rodolfo O. , Slavenko Alex , Chapple David G. 
Published: May 2022

AbstractAimLimb‐reduced squamates are a convenient model system to investigate macroevolutionary trends in morphology. Here, we provide morphological, ecological and literature data on all known species of limb‐reduced skinks (Scincidae) and their relatives, representing one of the most diverse and widely distributed groups of limb‐reduced squamates.LocationGlobal.TaxonSkinks (Reptilia, Squamata: Scincidae). Limb‐reduced forms.MethodsMorphological data were sourced from the primary literature, spanning a period of over 150 years. Linear body measurements were averaged across all values in the literature, preserving proportionality to body length. For digits and presacral vertebrae, we used maximum recorded counts. Ecological and biogeographical data were sourced from habitat assessments in the primary literature, online databases and field guides. Literature data were sorted according to type of study. To exemplify the applicability of the database, we used Markov‐chain ordered models to estimate the evolutionary frequency of limb reduction and loss in skinks.ResultsWe find evidence of limb reduction and loss in a total of 394 species worldwide, representing ~23% of all skink species, and ~30% of genera. The distribution of limb‐reduced and limbless forms differs from that of fully limbed forms, as they are present in all biogeographic realms with the almost complete exclusion of the Americas. We estimate that limb reduction evolved more than 50 times in skinks, and that loss of at least one limb pair evolved at least 24 times.Main conclusionsThe dataset captures a broad spectrum of morphological and ecological variation in a large, globally distributed taxonomic group. It establishes a widely applicable definition of limb reduction based on limb proportions as a reference for future studies. Such an extensive collection of morphological and ecological data can pave the way for investigations of dramatic morphological transitions and their ecological drivers at a global and local scale.
Thirty‐five years of the Journal of Computer Assisted Learning: A bibliometric overview
Authors: Akturk Ahmet Oguz 
Published: May 2022

AbstractBackgroundJournal of Computer Assisted Learning (JCAL), which started its publication life in 1985, is a leading international journal in the field of computer and instructional technologies and celebrated its 35th anniversary in 2020.ObjectivesThis study aims to provide a bibliometric overview of leading publication and citation trends of JCAL over the past 35 years. In order to achive the aim of the study, metadata of all the articles (N = 1305) published in the journal in this process were obtained from the Scopus database.MethodsThe study includes JCALs bibliometric analyses such as the total number of articles and citations, h‐index, citations per paper, citations per year, citation thresholds, average number of citations per year and annual citation counts between 1985 and 2020. In addition, the study presents visual maps based on citation, co‐citation, bibliographic coupling, co‐authorship and co‐occurrence of author keywords with a bibliometric mapping analysis performed with VOSviewer software.Results and ConclusionsThe results indicate that JCAL has become one of the leading journals over time in the field of computer and instructional technologies, as indicated by citation counts of articles published in JCAL, receiving citations from publications in esteemed journals, and publishing international rigorous work. Additionally, researchers who have published in JCAL in recent years have directed their attention to subjects such as learning analytics, massive open online courses (MOOCs), multimedia learning, game‐based learning, blended learning, online learning, mobile learning and virtual reality.ImplicationsFurther investigation of the scientific collaboration of authors who conduct research in different disciplines related to education, topics and education levels may yield more diverse perspectives.
How does stigma influence depressive symptoms among women who underwent termination of pregnancy for foetal anomaly: A path analysis
Authors: Li Xi , Peng Huiting , Hu Siqing , Xie Jiaying , Qin Chunxiang 
Published: May 2022

AbstractAim and ObjectivesThe purpose of this study was to explore the effect and paths of stigma on depressive symptoms in women who underwent termination of pregnancy for foetal anomaly (TOPFA).BackgroundStigma may cause distress and depressive symptoms for women with TOPFA. However, few studies have examined the relationship between stigma and depression in women with TOPFA.DesignThis study followed the STROBE checklist. A cross‐sectional survey was conducted among 469 women with TOPFA. The path analysis used hierarchical multiple regression and structural equation model to examine the mediating role of social support and psychological flexibility on the relationship between stigma and depressive symptoms.ResultsHierarchical multiple regression analysis revealed the mediation effect of psychological flexibility between stigma and depressive symptoms. By contrast, social support did not present such effect. The structural equation model confirmed that stigma, directly and indirectly, affected depressive symptoms.DiscussionMany women with TOPFA have severe depressive symptoms and that stigma is an important influencing factor. Psychological flexibility plays an essential role in mitigating the effects of stigma on depressive symptoms.Relevance to clinical practiceHealthcare professionals should focus on measuring and intervening on stigma and psychological flexibility for alleviating the depressive symptoms of women with TOPFA.No Patient or Public Contribution.
Sensorial, textural, and nutritional attributes of coconut sugar and cocoa solids based “bean‐to‐bar” dark chocolate
Authors: Beegum P.P Shameena , Pandiselvam Ravi , S.V. Ramesh , P Sugatha , Nooh Arifa , S Neenu , Gupta Alka , Varghese Eldho , Balasubramanian D. , Apshara Elain S. , Manikantan Musuvadi Ramarathinam , Hebbar Kukkehalli Balachandra 
Published: May 2022

AbstractThe impacts of cocoa solids and coconut sugar on the sensory perception of bean‐to‐bar dark chocolate were investigated with mixture design using response surface methodology. The maximum and minimum levels of cocoa nib, cocoa butter, and coconut sugar for the preparation of chocolate were 35–50%, 15–30%, and 20–35%, respectively. A suitable mathematical model was used to evaluate each response. Maximum and minimum levels of components caused a poor sensory acceptance of the resultant dark chocolate. The optimum level of independent variables, for the best set of responses, was 44.7% cocoa nib, 25.2% cocoa butter, and 30.2% coconut sugar, with a hedonic score of 8.28 for appearance, 8.64 for mouth feel, 8.71 for texture, 8.68 for taste, and 8.51 for overall acceptability, at a desirability of 0.86. The minimum time for grinding the chocolate mix was 24 hour, which was evident from the microscopic analysis of the chocolate mix. The optimized chocolate (70% dark) per 100 g constitutes 1.06 g moisture, 50.09 g crude fat, 10.37 g crude protein, 35.90 g carbohydrates, and 2.55 g ash content. The L, a, b values indicated a darker color and was stable under ambient condition with a hardness value of 59.52 N, which significantly decreased to 16.23 N within 10 min at ambient temperature (30 ± 2°C). The addition of coconut sugar along with cocoa solids incorporates polyphenols, flavonoids, antioxidant potential, and minerals into bean‐to‐bar dark chocolate and hence offers a commercial value and health potential for stakeholders.
Secreted hepatitis B virus splice variants differ by HBV genotype and across phases of chronic hepatitis B infection
Authors: Maslac Olivia , Wagner Josef , Sozzi Vitina , Mason Hugh , Svarovskaia Jenny , Tan Susanna , Gaggar Anuj , Locarnini Stephen , Yuen Lilly , Littlejohn Margaret , Revill Peter A. 
Published: May 2022

AbstractChronic hepatitis B (CHB) is characterized by progression through different phases of hepatitis B virus (HBV) infection and disease. Although not necessary for HBV replication, there is increasing evidence that HBV splice variants are associated with liver disease progression and pathogenesis. However, there have been no studies till date on the frequency or diversity of splice variants for different HBV genotypes across the phases of CHB. Next generation sequencing data from 404 patient samples of HBV genotype A, B, C or D in Phase I, Phase II or Phase IV of CHB was analysed for HBV splice variants using an in house bioinformatics pipeline. HBV splice variants differed in frequency and type by genotype and phase of natural history. Splice variant Sp1 was the most frequently detected (206/404, 51% of patients), followed by Sp13 (151/404 37% of patients). The frequency of variants was generally highest in Phase II (123/165, 75% of patients), a phase typically associated with enhanced immune activation, followed by Phase I (69/99, 70% of patients). Splice variants were associated with reduced hepatitis B e antigen (HBeAg) levels and statistically reduced likelihood of achieving HBsAg loss (functional cure) in Phase II patients for Sp1 and Sp13 (p = .0014 and .0156, respectively). The frequency of HBV splice variants in patient serum differed markedly by HBV genotype and phase of CHB natural history. The increased levels of HBV splice variants detected in CHB phase II patients compared with the higher replicative Phase I in particular warrants further investigation.
Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma
Authors: Ito Yu , Abe Atsushi , Hayashi Hiroki , Momokita Moeko , Furuta Hiroshi 
Published: May 2022

AbstractObjectivesTo investigate the prognostic impact of preoperative Geriatric Nutritional Risk Index (GNRI) values in older adults undergoing radical surgery for oral squamous cell carcinoma (OSCC).Subjects and methodsThis retrospective study included 61 patients ≥65 years old with OSCC (43 men, 18 women; age: 72.1 ± 5.4 years) who underwent radical surgery between 2013 and 2020. Factors influencing overall survival (OS) and disease‐free survival (DFS) were examined.ResultsReceiver operating characteristic curve analysis indicated that the optimal GNRI value for classifying patients into low‐GNRI (<93.7; OS: n = 19 [31.1%], DFS: n = 42 [68.9%]) and high‐GNRI groups (≥93.7; OS, n = 19 [31.1%]; DFS, n = 42 [68.9%]) was 93.7. OS and DFS rates were significantly lower in the low‐GNRI group than in the high‐GNRI group. Univariate analysis indicated that alcohol use, preoperative serum C‐reactive protein level, lymphatic invasion, postoperative treatment, and GNRI were significantly correlated with OS, while lymphatic invasion, postoperative treatment, and GNRI were significantly correlated with DFS. In multivariate analysis, only GNRI was significantly correlated with OS. DFS and postoperative treatment were independent predictors of DFS.ConclusionsPreoperative GNRI may be a significant prognostic factor in older adults with OSCC. GNRI assessment and nutritional intervention may improve prognosis in patients at high nutritional risk.
A rare cause of syncope in patients with situs inversus totalis and corrected transposition of the great arteries: Very late lead perforation
Authors: Kuş Görkem , Çağırcı Göksel , Üreyen Çağın Mustafa , Ersoysal Rıdvan , Arslan Şakir 
Published: May 2022

AbstractSitus inversus c‐TGA refers to a complex anatomical malformation. The risk of developing AV block increases by 2% per year. Pacemaker lead perforation is a rare but serious complication after pacemaker implantation and that develops more than 1 month is defined as late lead perforation. Here, we presented a case of very late lead perforation that occurred 5 years later after pacemaker implantation in a patient with congenital heart disease who had pacemaker due to AV block. Even in the late period, this complication should be kept in mind in patients with a pacemaker who present with syncope.
Severe acne and its variants: Exploring its natural history and heritability
Authors: Greywal Tanya , Kusari Ayan , Han Allison M. , Borok Jenna , Proudfoot James A. , Ahluwalia Jusleen , Friedlander Sheila Fallon 
Published: May 2022

AbstractBackgroundAcne vulgaris varies in clinical severity, from minimal comedonal disease to severe hemorrhagic and ulcerative lesions with scarring. While a family history confers a higher risk for developing acne, the correlation between heritability and clinical severity remains unclear.ObjectiveTo examine the natural history and heritability of severe acne with scarring in patients undergoing isotretinoin therapy.MethodsA total of 101 subjects with severe acne with scarring and its variants, including acne conglobata and acne fulminans, were enrolled. All subjects and adult family members underwent an interview regarding their acne, and a corresponding “historical” Investigator's Global Assessment (hIGA) score (0 = clear, 1 = almost clear, 2 = mild, 3 = moderate, 4 = severe, 5 = very severe) was assigned. Study assessors performed an “examination” Investigator's Global Assessment (eIGA) based on the clinical examination of each subject (0 = clear, 1 = almost clear, 2 = mild, 3 = moderate, 4 = severe, 5 = very severe). A detailed family history and pedigree were documented.ResultsMost subjects were Caucasian (44.5%) and male (79.2%) who had previously used doxycycline and/or minocycline (86.1%). The mean eIGA and hIGA scores were 2.7 and 4.4, respectively. 37.2% of subjects had one first‐degree relative with a history of moderate or severe acne with scarring; of note, of the patients with hemorrhagic disease, 30% had at least one parent with moderate or severe acne.ConclusionsSevere forms of acne often “cluster” in families, underscoring the heritable nature of acne and the prognostic value of a family history of moderate or severe disease.
Low post‐transplant measles and varicella titers among pediatric liver transplant recipients: A 10‐year single‐center study
Authors: Liman Andrew Y. J. , Wozniak Laura J. , de St Maurice Annabelle , Dunkel Gregory L. , Wanlass Emy M. , Venick Robert S. , McDiarmid Sue V. 
Published: May 2022

AbstractBackgroundVaccine preventable illnesses are important sources of morbidity, mortality, and increased healthcare costs in pediatric LT recipients. Our aim was to measure the seroprevalence of antibodies to measles and VZV in this population.MethodsWe conducted a retrospective chart review of 44 patients who received LT before age 18 at UCLA Mattel Children's Hospital from January 2008 to December 2017.ResultsMedian age at transplantation was 2.5 years (IQR 1.2–7.7). Post‐transplant measles antibodies were present in 17 of 37 patients (46%); risk factors for seronegativity included younger age at transplant (p = .02) and greater time from transplant to testing (p = .04). Post‐transplant VZV antibodies were present in 17 of 39 patients (44%); risk factors for seronegativity included greater time from transplant to testing (p = .04). 6 of 16 patients (38%) who tested positive for pre‐transplant VZV antibodies tested negative after transplantation. Fourteen of 20 patients (70%) with at least 1 documented dose of the MMR vaccine tested positive for post‐transplant measles antibodies. Ten of 20 of patients (50%) with at least 1 documented dose of the VZV vaccine tested positive for post‐transplant VZV antibodies. We also describe 10 patients who received post‐transplant measles and VZV vaccines without documented complications.ConclusionsOur study suggests that pediatric LT patients are at greater risk of contracting measles and VZV despite vaccination status, and that prevalence of measles and VZV antibodies decreases as time from transplantation increases. This should weigh into the institutional risk–benefit assessment when deciding whether or not to administer LAVs to these patients.
Choose your collaborators wisely: Addressing interdependent tasks through collaboration in responding to wildfire disasters
Authors: Bodin Örjan , Guerrero Angela M. , Nohrstedt Daniel , Baird Julia , Summers Robert , Plummer Ryan , Jasny Lorien 
Published: May 2022

AbstractResponding to disastrous wildfires traversing geographical scales requires multi‐actor collaboration to address a series of interdependent operational tasks. While this type of distributed collective action problem is salient across governance contexts, less is known about if and how collaboration helps individual actors effectively address their tasks. Applying a novel network‐centric method to wildfire responder networks in Canada and Sweden, this study shows that when actors working on the same tasks collaborate, and/or when one actor addresses two interdependent tasks, effectiveness increases. The number of collaborative ties an actor has with others does not enhance effectiveness. Furthermore, when the chain of command is unclear, and/or when actors lack recent disaster management experience and/or pre‐existing collaborative relationships, effectiveness only increases if multiple actors collaborate over multiple interdependent tasks. The results have implications for disaster response agencies, and they provide valuable insights for collaborative responses to significant societal and environmental challenges.