bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Mesenchymal Stem Cells in Regulating PDGF and VEGF during Pancreatic Islet Cells Regeneration in Diabetic Animal Model
Authors: Putra Agung , Suwiryo Zakariya Hadi , Muhar Adi Muradi , Widyatmoko Agus , Rahmi Fifin Luthfia 
Published: December 2021

Introduction: Diabetes is a heterogeneous group of metabolic diseases characterized by elevated blood glucose due to autoimmune disorder or a combination of insulin resistance and insulin deficiency. VEGF and PDGF are the main actors in the regeneration of damaged pancreatic tissue. However, the prolonged release of these molecules may induce fibrosis formation. Mesenchymal stem cells (MSCs) have a high potential to regenerate damaged pancreatic tissue by releasing PDGF and VEGF.
Aim: This study aimed to investigate the effect of MSCs on the levels of PDGF and VEGF on days 2 and 44 in diabetic mice and determine the number of pancreatic islet cells and blood glucose levels.
Materials and methods: This study used a post-control group design with animals divided into five groups: sham, control, and three treatment groups (P) which were given MSCs at doses of 1.5&times;105, 3&times;105, and 6&times;105 cells. The levels of PDGF, VEGF, and blood glucose were measured by enzyme-linked immunosorbent assay (ELISA), while the number of pancreatic islet cells was analyzed using H&amp;E staining.
Results: This study showed a significant increase of VEGF and PDGF levels on day 2 and a significant increase in islet cell percentages on day 44 in line with the decreased blood glucose level. However, there was no difference between VEGF and PDGF levels on day 44.
Conclusions: MSCs regulate PDGF and VEGF levels in wound healing phases and remodel pancreatic islet &beta;-cells regeneration to control blood glucose in diabetic model mice.
Sorghum Protein Extract Protects RBC from Sodium Nitrite-Induced Oxidative Stress and Exhibits Anticoagulant and Antiplatelet Activity
Authors: Sannaningaiah Devaraja , Shivaiah Ashwini , Kengaiah Jayanna , Srinivasa Chandramma , Nandish Sharath Kumar M. , Ramachandraiah Chethana , Hanumegowda Sujatha , Manjappa Bhagyalakshmi , Martin Sebastin Santosh , Laxmaiah Ramesh Komalapura , Shinde Manohar 
Published: December 2021

Introduction: Oxidative stress plays a critical role in the progression of diabetes, arthritis, cancer, eryptosis, cardiovascular disease, and thrombosis. Currently, antioxidants from natural sources are in high demand due to their beneficial role in the management of said diseases.
Aim: The purpose of the study was to evaluate the protective effect of sorghum protein buffer extract (SBE) on sodium nitrite-induced oxidative stress and thrombosis.
Materials and methods: Protein characterization of SBE was done using SDS-PAGE. Oxidative stress in RBC was induced using sodium nitrite (NaNO2) and the key stress markers such as lipid peroxidation (LPO), protein carbonyl content (PCC), and the level of antioxidant enzymes (SOD and CAT) were measured. The anticoagulant effect of SBE was identified by employing in-vitro plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT), and in-vivo mouse tail bleeding time. SBE antiplatelet activity was examined using agonist adenosine diphosphate (ADP) and epinephrine-induced platelet aggregation. Non-toxic property of SBE was identified using in-vitro direct haemolytic, haemorrhagic, and edema forming activities using experimental mice.
Results: SBE revealed similar protein banding pattern under both reduced and non-reduced conditions on SDS-PAGE. Interestingly, SBE normalized the level of LPO, PCC, SOD, and CAT in stress-induced RBCs. Furthermore, SBE showed anticoagulant effect in platelet rich plasma by enhancing the clotting time from the control 250 s to 610 s and bleeding time from the control 200 s to more than 500 s (p<0.01) in a dose dependent manner. In addition, SBE prolonged the clot formation process of only APTT but not PT. SBE inhibited the agonists ADP and epinephrine induced platelet aggregation. SBE did not hydrolyze RBC cells, devoid of edema and haemorrhage properties.
Conclusions: This study demonstrates for the first time the anticoagulant, antiplatelet, and antioxidant properties of SBE. Thus, the observed results validate consumption of sorghum as good for health and well-being.
Dosage of Lipid Emulsions as an Antidote&nbsp;to Lipid-Soluble Substances
Authors: Kehayova Gabriela , Zlateva Snezha , Marinov Petko 
Published: December 2021

Introduction: Lipid emulsions are increasingly used as an antidote to lipophilic drug intoxications. The dose recommended by the American Society of Regional Anesthesia is used primarily for the treatment of local anesthetic systemic toxicity. There is insufficient information about what the dose of lipid emulsions (LE) should be in other intoxications depending on their severity.
Aim: To determine the LE dose in a shock or haemodynamic instability in patients with acute exogenous intoxications treated with LE.
Materials and methods: Forty-nine patients with acute lipophilic drug intoxications were treated with LE in the Clinic of Toxicology at the Naval Hospital in Varna.
Statistical analysis was performed using the statistical functions of Excel 2016 and the Statistica 7.0 software package.
Results: The percentage of patients receiving a low dose of LE of 0.3 ml/kg (93.87%) was significantly higher than the percentage of patients treated with a medium (2.04%) and a high dose (4.08%) of LF. The high dose of LE of 1.5 ml/kg recommended by the American Society of Regional Anesthesia was administered to two patients (4.08%). In severe intoxications with exotoxic shock, the rate of LE administration varies from 20 ml/h to 40 ml/h.
Conclusions: In severe intoxications with cardiotoxic syndrome and haemodynamic instability, LE should be used in the dose as suggested by the American Society of Regional Anesthesia. It is possible to use lower doses of LE in the range of 0.3&ndash;0.6 ml/kg in all moderate poisonings administered by continuous intravenous infusion for 12-24-48 hours. No side effects were observed at these doses.
Efficacy of Bioelectrical Impedance Analysis for the Evaluation of Physical Impairment in Chronic Low Back Pain. Results from a Cohort Study
Authors: Kechagias Dimitrios , Chatzipapas Christos , Karaglani Makrina , Tilkeridis Konstantinos , Ververidis Athanasios , Drosos Georgios 
Published: December 2021

Introduction: Determining the effect of body composition on chronic low back pain seems to have the potential to improve our understanding of its mechanism and to develop novel preventive and therapeutic approaches.&nbsp;
Aim: The purpose of the present study was to assess by electrical impedance the composition of lower extremities of individuals with chronic low back pain.
Materials and methods: One hundred and twenty-one adult participants with diagnosed chronic low back pain were recruited in this study. The study activities were divided into three phases: phase 1 &ndash; self-administered questionnaires, phase 2 &ndash; biomedical examination (including anthropometric measurements and physical function performance tests), and phase 3 &ndash; bioimpedance analysis.
Results: Our results showed that chronic low back pain differentiates the circumference of thigh and calf of the symptomatic leg. Besides, patients experience pain also in hip, thigh, and calf, which act as a barrier to patient&rsquo;s personal, professional, social, and recreational activities. Furthermore, patients appear with &lsquo;unstable&rsquo; walking, reduced balance, and reduced general physical condition that affect all of the neuromuscular structures of the locomotor system. Interestingly, patients seem to be characterized by a tendency to deposit fat and to decrease muscle mass in the symptomatic limb regardless of the gender.
Conclusions: In the present study, we determine the profile of a patient with chronic low back pain through a variety of measurements. Chronic low back pain causes several structural changes to the symptomatic leg of the patients leading to &lsquo;unstable&rsquo; walking, reduced balance, and reduced general physical condition. It is clear that further studies using bioimpedance analysis are needed to address the concerns raised by investigating a multifactorial condition such as chronic low back pain.
Evaluation of Oxidative Stress Biomarkers&nbsp;in Patients with Henoch-Sch&ouml;nlein Purpura
Authors: Soylemez Kadir , Temiz Fatih , Dalkiran Tahir , Kandur Yasar , Belge Kurutas Ergul , Unsal Velid , Oner Erkan 
Published: December 2021

Introduction: Henoch-Sch&ouml;nlein Purpura (HSP) is a systemic vasculitic syndrome characterized by non-thrombocytopenic purpura, arthritis/arthralgia, abdominal pain, and glomerulonephritis. The pathogenesis of HSP has not been clearly identified. Oxidative damage has a role in the pathogenesis of most cases.
Aim: This study aimed to evaluate changes of oxidative stress by studying parameters like superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in an attempt to identify the role of oxidative stress in HSP from another perspective.
Materials and methods: This study enrolled 23 pediatric patients (ten girls and thirteen boys) diagnosed with HSP who were under follow-up at Sutcu Imam University School of Medicine Department of Pediatrics between 2014 and 2016 and twenty healthy children as the control group. The parents of all subjects gave informed consent to participate in the study. In the HSP group, the beginning season of the illness and the systemic involvement during follow-up were determined. Blood specimens were obtained at presentation before any treatment was started. SOD, CAT activities, and MDA values in erythrocyte and plasma samples were compared between the patient group and the healthy children.
Results: Twenty-three patients with HSP (13 males, 10 females) and 20 healthy children participated in this study. The mean age of the HSP cases was 8.21&plusmn;3.78 years (range 2-16 years) and of the controls was 8.6&plusmn;4.2 (range 3-14 years). The mean MDA value was 2.95&plusmn;0.71 nmol/ml in the patient group and 2.67&plusmn;0.66 nmol/ml in the control group (p=0.787). The mean level of the CAT enzyme was 1.32&plusmn;0.35 U/g Hb in the patient group and 7.8&plusmn;1.74 U/g Hb in the control group (p=0.001). The mean levels of the SOD enzyme were 3.06&plusmn;0.85 U/g Hb in the patient group and 0.97&plusmn;0.36 U/g Hb in the control group (p=0.001).
Conclusions: Although high MDA levels support the role of lipid peroxidation in the pathogenesis of HSP, statistical significance was not reached owing to a limited number of our patients. The reduced CAT enzyme activity is consistent with the findings of previous reports. This finding supports the notion that oxidative stress can play a role in the pathogenesis of HSP.
Keypoints: Our findings support the notion that oxidative stress can play a role in the pathogenesis of HSP.
Ni vieux ni jeunes : les vieillesses bourgeoises et la recherche d’un troisième terme
Authors: Pillonel Alexandre 
Published: December 2021

Dans un contexte marqué par un impensé des classes sociales au sein des analyses sociologiques du vieillissement, cet article a pour ambition d’apporter une contribution à la compréhension du processus de vieillissement des classes supérieures. Sur la base d’une étude qualitative, cet article met en lumière comment trois dispositions caractérisent le rapport que les personnes âgées issues de la bourgeoise entretiennent à leur vieillesse. En perturbant des oppositions significatives produites par le champ disciplinaire de la gérontologie, ces modèles de vieillesse peuvent alors se comprendre comme l’expression d’un « désir de neutre » (Barthes, 1990) et la recherche d’un troisième terme.
D’un canapé à l’autre, la série En thérapie comme spectacle de l’expressivité
Authors: de Saint Maurice Thibaut 
Published: December 2021

Diffusée en février et mars 2021 sur Arte, la série En thérapie plonge le spectateur dans le cabinet d’un psychanalyste et lui permet d’être le témoin du parcours de cure de plusieurs patients. Les récits des patients se déroulent sur une toile de fond commune : celle de l’onde de choc des attentats des terrasses et du Bataclan de novembre 2015. Cet article a pour intention de montrer comment cette sérié articule d’une part le récit du choc collectif et les récits des chocs individuels. Et d’autre part, comme cette fiction sérielle procure une expérience de l’expressivité qui permet de renouveler la compréhension du soin que l’on peut prendre les uns des autres.
Methods for estimating and modelling spruce budworm development rates at constant temperatures
Authors: Wardlaw A.A. , Perrault K. , Roe A.D. , Dedes J. , Irwin C.L. , MacQuarrie C.J.K. , Candau J.-N. 
Published: December 2021

Abstract
We describe an experimental protocol for measuring the response of spruce budworm postdiapause larval development to temperature. This protocol is specifically designed to include measurements of development near their upper and lower thermal thresholds. The application of this protocol to a laboratory colony allowed for the first experimental evidence that spruce budworm larval development occurs at temperatures as low as 5 °C and as high as 35 °C, and it provides data to fit stage-specific development models. Our protocol is also designed to minimise mortality near the thermal development thresholds, thus allowing for multigenerational studies. We observed developmental plasticity in larvae reared at constant temperatures, particularly the occurrence of up to 42% of some individuals requiring only five instars to complete development compared to the expected six instars. The occurrence exhibited no clear relation to temperature. Although this protocol is specifically designed for spruce budworm, it provides a template for the study of other species’ developmental responses to temperature.
The biota of Canada: checklist of the centipedes of Canada (Myriapoda: Chilopoda)
Authors: Langor David W. , Langor Stephen D. 
Published: December 2021

Abstract
The centipede fauna of Canada is reviewed based on information available in the literature and on examination of some material, and provincial and territorial distributions are provided. About 53 species are known from Canada, representing four orders: Scutigeromorpha (1), Scolopendromorpha (5), Geophilomorpha (19), and Lithobiomorpha (28). British Columbia has the most recorded species (23), followed by Ontario (17) and Newfoundland and Labrador (12). Arctogeophilus glacialis (Attems) and Alaskobius adlatus Chamberlin are newly reported from Canada (Northwest Territories), Schendyla nemorensis (Koch) is newly reported from Ontario, and Lithobius forficatus (Linnaeus) is recorded for the first time from New Brunswick and Prince Edward Island. Arctogeophilus melanonotus (Wood) is removed from the list of Canadian species.
Trends of malnutrition from 1947-2021 among under-five children in India
Authors: Rohatgi Shivani , Suri Sukhneet , Kumar Praveen 
Published: December 2021

Context:
Malnutrition is a silent emergency and a leading cause of morbidity and mortality amongst children under 5 years of age. There are intra and inter-generational consequences of malnutrition.

Aim:
To study the trends of prevalence of malnutrition among under-five children in India since its independence.

Subjects and Methods:
The trends in malnutrition indicators from 1947 to 2021 in India through 40 studies out of 186 descriptive, cross-sectional and epidemiological studies, reports, etc., from the national and international electronic databases were reviewed and analysed.

Results:
Indicators of malnutrition have changed over the years. There is the paucity of data on child malnutrition from 1947 to 1972. Until the 1980s, the data were represented in the proportion of under-five children falling below a specified percent of the median as per weight-for-age. From 1980 to 2021, the data on the nutrition status of children under five are available as prevalence based on weight-for-age, height-for-age and weight-for-height. Overall, not much progress can be observed towards achieving sustainable development goals (SDGs) targets for underweight, stunting and wasting since 2005.

Conclusions:
The past seven decades have witnessed upward as well as downward trends during various periods of time in the prevalence of undernutrition. However, there has always been an upward trend in the prevalence of over-nutrition. To achieve SDG-2 by 2030, i.e., to reduce and maintain wasting by 5%, stunting by 40% and no further increase in childhood obesity, there is a need to strengthen the existing strategies and focus on the most vulnerable and critical age groups.
A Tale of Two Pathologies
Authors: Saravanan M. N. , Vaithiswaran V. , Mathew Ashwathy S. , Sundaraiya Sumati , Sulaiman Abubacker , Rajendran Adhithyan , Patil Sushama , Chilukuri Srinivas , Nangia Sapna , Raja T. 
Published: December 2021

Background:
In workup for a tumor in an individual, a second pathology is discovered at times, which can complicate further management. Cross-sectional imaging is widely utilized in gastrointestinal tumors leading to identification of incidentalomas, and we audited our multidisciplinary team (MDT) meeting data in order to analyze the implications and refine the approach in the presence of dual pathology.

Materials and Methods:
This study was a retrospective assessment of a prospectively maintained single institute gastrointestinal tumor board MDT database between June 2019 and June 2020.

Results:
Of the 76 patients discussed in the gastrointestinal MDT, 21 patients associated with clinically relevant second pathology were included in the study group. Positron emission tomography–computed tomography (PET-CT) was the most common modality responsible for detection of the second pathology. Additional workup to better characterize these findings was needed in 10 (47.6%) patients. Eleven patients had dual neoplasms, of which four accounted for dual malignant neoplasms. MDT resulted in a change in plan in 6 (28.6%) patients, which was mainly related to radiology review, thereby downstaging to the correct stage.

Conclusions:
PET-CT increases detection of a second pathology in gastrointestinal tumors. Appropriate review of radiology, supplementing with additional imaging and/or biopsy, and wait and reassess in selected situations in an MDT is pivotal in management of a double pathology.
Corneal Hysteresis, Central Corneal Thickness, and Intraocular Pressure in Rheumatoid Arthritis, and Their Relation to Disease Activity
Authors: Nossair Ashraf Ahmed , Kassem Mona Kassem , Eltanamly Rasha Mounir , Alahmadawy Yomna Amr 
Published: December 2021

PURPOSE:
To evaluate biomechanical properties, corneal thickness, and intraocular pressure (IOP) in patients with rheumatoid arthritis (RA) and correlate them with rheumatoid activity.

PATIENTS AND METHODS:
Forty RA eyes were enrolled in a cross-sectional study. Clinical Disease Activity Index (CDAI) was used to assess the rheumatoid activity by a rheumatologist. Corneal hysteresis (CH), corneal resistance factor (CRF), and IOP corneal compensated, IOP Goldmann corrected were assessed using ocular response analyzer (ORA), Corneal thickness was measured using optical coherence tomography, and IOP using Goldman applanation tonometer (IOP GAT).

RESULTS:
There was a positive correlation between CH and CRF (P < 0.001 and r = 0.818) and (P < 0.001 and r = 0.714) in the active and inactive groups respectively, also between CRF and central corneal thickness (CCT) (P value 0.05 and r = 0.0435) in Inactive Group only. No correlation was found between CDAI score and ORA parameters. There was a negative correlation between CDAI and CCT in Active Group only (P < 0.001 and r = −0.823).

CONCLUSION:
Corneal biomechanical properties could be affected in rheumatoid patients in both active and remission phases, which may indicate that any corneal changes may be irreversible. These changes are of important significance regarding IOP measurement in rheumatoid patients. CCT may be a new parameter in the follow up of disease activity.
Spatial variability of soil erodibility in pastures and forest areas in the municipality of Porto Velho, Rondônia
Authors: Silva Lucivânia Izidoro da , Campos Milton César Costa , Brito Wildson Benedito Mendes , Cunha José Maurício da , Lima Alan Ferreira Leite de , Santos Luís Antônio Coutrim dos , Hassane Abdul Luís 
Published: December 2021

“Erodibility” is a characteristic of the soil that represents the susceptibility with which its particles from the most superficial layer are taken and transported to lower places by erosive agents, causing environmental and economic damages. This work estimated soil erodibility in pastures and forest areas in the municipality of Porto Velho-Rondônia. In the field, three areas with different types of vegetation were selected, one with brachiaria, another with mombaça grass, and a third in native forest. In areas with pastures, a sampling mesh of equal sizes was outlined (90 m x 60 m), and in the forested area an approximate sampling mesh (90 m x 50 m), with a regular spacing of 10 m between the samples points for both areas. The sampling was done at the crossing points of the mesh at a depth of 0.0-0.2 m, composing 70 sample points in the areas with pastures and 60 sample points in the forest area, totaling 200 samples. Then, laboratory analyzes were carried out to determine the texture followed by the fractionation of the sand, and the organic carbon followed by the estimate of the organic matter of the soil. The erodibility factors were calculated using indirect prediction models, and then, univariate, geostatistical and multivariate techniques were applied. The pastures’ environments differed from the forest environment. However, the mombaça grass area functions as an intermediate environment between the forest and the brachiaria, being closer to the forest environment.
Keywords: erodibility, factors, kriging, principal components.
Penguatan Literasi Digital Generasi Muda Muslim dalam Kerangka Konsep Ulul Albab
Authors: Wahyudi Tian 
Published: December 2021

Artikel ini mengkaji bagaimana penguatan literasi digital mengacu kepada konsep Ulul Albab. Melalui pengkajian terhadap berbagai literatur yang relevan dengan topik pembahasan, artikel ini bertujuan untuk mengkaji komponen-komponen utama ulul albab dan menjadikannya sebagai kerangka bagi penguatan literasi digital generasi muda muslim. Komponen-komponen tersebut yaitu dzikir, pikir, dan amal shaleh. Melalui penguatan pada tiga komponen tersebut generasi muda muslim mampu mengoptimalkan media digital sebagai sarana pengembangan diri dan dapat berkontribusi bagi kemaslahatan umat dan masyarakat secara umum. Meningkatkan dzikrullah hakikatnya adalah membangun dan meningkatkan kesadaran seorang muslim akan visi dan misi hidupnya bahwa kehidupan dunia harusnya menjadi bekal untuk mendapatkan kebaikan Akhirat. Dalam berbagai keadaan dan aktivitas, dia selalu sadar bahwa segala perbuatan yang dilakukan-sekecil apapun memiliki konsekwensi bagi kehidupannya di masa depan. Demikian pula saat bermedia digital, dia akan mengoptimalkan sarana digital untuk kebaikan dan menghindari berbagai sikap dan prilaku yang buruk, yang bertentangan dengan syariat Islam. Sementara untuk penguatan dari aspek pikir yaitu dengan menguatkan dan meningkatkan kemampuan berpikir kritis dan menjadikan media digital sebagai sarana peningkatan wawasan dan keterampilan. Adapun amal shaleh, sejatinya tidak terlepas dari aspek dzikir dan pikir. Semakin baik kualitas dzikir dan pikirnya, maka hal tersebut akan mendorong kepada kualitas amalnya juga. Media digital dapat menjadi sarana dalam melakukan berbagai kebaikan yang berlandaskan syariat yaitu dengan: (1) menebarkan ilmu yang bermanfaat; (2) menyeru kepada kebaikan dan mencegah kemunkaran; (3) memprodukasi berbagai media atau konten digital yang positif-edukatif dan Islami; (4) menguatkan silaturrahim dan ukhuwwah Islamiyyah, serta (5) menjaga akhlak dalam bermedia sosial.