bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment : integrated computational analysis and in vitro study
Authors: Hermawan Adam , Wulandari Febri , Hanif Naufa , Utomo Rohmad Yudi , Jenie Riris Istighfari , Ikawati Muthi , Tafrihani Ahmad Syauqy 
Published: August 2022

AbstractThe treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the brain, the limited capacity of brain cells to repair, resistance to conventional therapy, and its aggressiveness. Curcumin has anticancer activity against aggressive cancers, such as leukemia, and GBM; however, its application is limited by its low solubility and bioavailability. Chemoprevention curcumin analog 1.1 (CCA-1.1), a curcumin analog, has better solubility and stability than those of curcumin. In this study, we explored potential targets of CCA-1.1 in GBM (PTCGs) by an integrated computational analysis and in vitro study. Predicted targets of CCA-1.1 obtained using various databases were subjected to comprehensive downstream analyses, including functional annotation, disease and drug association analyses, protein–protein interaction network analyses, analyses of genetic alterations, expression, and associations with survival and immune cell infiltration. Our integrative bioinformatics analysis revealed four candidate targets of CCA-1.1 in GBM: TP53, EGFR, AKT1, and CASP3. In addition to targeting specific proteins with regulatory effects in GBM, CCA-1.1 has the capacity to modulate the immunological milieu. Cytotoxicity of CCA-1.1 was lower than TMZ with an IC50 value of 9.8 μM compared to TMZ with an IC50 of 40 μM. mRNA sequencing revealed EGFR transcript variant 8 was upregulated, whereas EGFRvIII was downregulated in U87 cells after treatment with CCA-1.1. Furthermore, a molecular docking analysis suggested that CCA-1.1 inhibits EGFR with various mutations in GBM, which was confirmed using molecular dynamics simulation, wherein the binding between CCA-1.1 with the mutant EGFR L861Q was stable. For successful clinical translation, the effects of CCA-1.1 need to be confirmed in laboratory studies and clinical trials.
Wave-like behaviour in (0,1) binary sequences
Authors: Canessa Enrique 
Published: August 2022

AbstractA comprehensive study of the properties of finite (0,1) binary systems from the mathematical viewpoint of quantum theory is presented. This is a quantum-inspired extension of the GenomeBits model to characterize observed genome sequences, where a complex wavefunction $$\psi _{n}$$

ψ
n

is considered as an analogous probability measure and it is related to an alternating (0,1) binary series having independent distributed terms. The real and imaginary spectrum of $$\psi _{n}$$

ψ
n

vs. the nucleotide base positions display characteristic features of sound waves. This approach represents a novel perspective for identifying and “observing” emergent properties of genome sequences in the form of wavefunctions via superposition states. The motivation is to develop a simple algorithm to perform wave calculations from binary sequences and to apply these wave functions to sonification.
Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction
Authors: Fraunhoffer Nicolas A. , Abuelafia Analía Meilerman , Bigonnet Martin , Gayet Odile , Roques Julie , Nicolle Remy , Lomberk Gwen , Urrutia Raul , Dusetti Nelson , Iovanna Juan 
Published: August 2022

AbstractPancreatic ductal adenocarcinoma (PDAC), has recently been found to be a heterogeneous disease, although the extension of its diversity remains to be fully understood. Here, we harmonize transcriptomic profiles derived from both PDAC epithelial and microenvironment cells to develop a Master Regulators (MR)-Gradient model that allows important inferences on transcriptional networks, epigenomic states, and metabolomics pathways that underlies this disease heterogeneity. This gradient model was generated by applying a blind source separation based on independent components analysis and robust principal component analyses (RPCA), following regulatory network inference. The result of these analyses reveals that PDAC prognosis strongly associates with the tumor epithelial cell phenotype and the immunological component. These studies were complemented by integration of methylome and metabolome datasets generated from patient-derived xenograft (PDX), together experimental measurements of metabolites, immunofluorescence microscopy, and western blot. At the metabolic level, PDAC favorable phenotype showed a positive correlation with enzymes implicated in complex lipid biosynthesis. In contrast, the unfavorable phenotype displayed an augmented OXPHOS independent metabolism centered on the Warburg effect and glutaminolysis. Epigenetically, we find that a global hypermethylation profile associates with the worst prognosis. Lastly, we report that, two antagonistic histone code writers, SUV39H1/SUV39H2 (H3K9Me3) and KAT2B (H3K9Ac) were identified key deregulated pathways in PDAC. Our analysis suggests that the PDAC phenotype, as it relates to prognosis, is determined by a complex interaction of transcriptomic, epigenomic, and metabolic features. Furthermore, we demonstrated that PDAC prognosis could be modulated through epigenetics.
Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
Authors: Brojakowska Agnieszka , Kour Anupreet , Thel Mark Charles , Park Eunbee , Bisserier Malik , Garikipati Venkata Naga Srikanth , Hadri Lahouaria , Mills Paul J. , Walsh Kenneth , Goukassian David A. 
Published: August 2022

AbstractWith planned deep space and commercial spaceflights, gaps remain to address health risks in astronauts. Multiple studies have shown associations between clonal expansion of hematopoietic cells with hematopoietic malignancies and cardiometabolic disease. This expansion of clones in the absence of overt hematopoietic disorders is termed clonal hematopoiesis (CH) of indeterminate potential (CHIP). Using deep, error-corrected, targeted DNA sequencing we assayed for somatic mutations in CH-driver genes in peripheral blood mononuclear cells isolated from de-identified blood samples collected from 14 astronauts who flew Shuttle missions between 1998–2001. We identified 34 nonsynonymous mutations of relatively low variant allele fraction in 17 CH-driver genes, with the most prevalent mutations in TP53 and DNMT3A. The presence of these small clones in the blood of relatively young astronaut cohort warrants further retrospective and prospective investigation of their clinical relevance and potential application in monitoring astronaut’s health.
Resonant energization of particles by radio AGN
Authors: Mahajan S. M. , Osmanov Z. N. 
Published: August 2022

Aims. A new mechanism of particle acceleration, based on the resonant interaction of a classical electromagnetic wave (EM) with a quantum wave (associated with a relativistic particle), is explored.
Methods. In a model illustrative calculation, we study the fate of a Klein Gordon wave subjected to the intense radio frequency waves generated in the vicinity of an active galactic nuclei (AGN). In the framework of the paper, we examine a quantum wave associated with a relativistic particle, and it is shown that the group velocity of the wave approaches the speed of light, implying that the particles resonantly exchange energy with EM waves, eventually leading to acceleration of particles to very high energies.
Results. For typical parameters of under accreting Eddington radio AGN, it is shown that the resonant energization could catapult particles to extreme energies ∼1016−20 eV.
Infektionskrankheiten und Infektionsprophylaxe in der Reisemedizin bei Kindern und Jugendlichen
Authors: Wendt Sebastian , Schneider Anne , Sasse Melanie , Paquet Dennis , Trawinski Henning , Lübbert Christoph 
Published: August 2022

ZUSAMMENFASSUNG2019 wurden 1,4 Milliarden internationale Reisen gezählt, wobei Deutschland zu den reisefreudigsten Nationen zählt. Kinder stellen in der Reisemedizin eine vulnerable Gruppe mit speziellem Beratungsbedarf dar. Eine qualifizierte reisemedizinische Beratung mindestens 4–6 Wochen vor einer Reise kann Gesundheitsrisiken bei Kindern und Eltern minimieren. Neben der Empfehlung einer adäquaten Auslandskrankenversicherung muss der aktuelle Impfstatus erhoben und komplettiert und ggf. um spezifische Reiseimpfungen ergänzt werden. Weitere Beratungsinhalte zielen auf Verhaltensmaßnahmen (z. B. Nahrungsmittelhygiene, Sonnenschutz), auf den Insektenschutz (Expositionsprophylaxe) sowie auf die Malariaprophylaxe in Risikogebieten. Der betreuende Kinderarzt sollte die wichtigsten Reise- und Tropenerkrankungen in Grundzügen kennen. Viele reiseassoziierte Infektionskrankheiten wie Durchfälle oder Hauterkrankungen können kompetent vom Kinderarzt behandelt werden. Im Zweifelsfall ist frühzeitig Kontakt mit einem reise- oder tropenmedizinischen Zentrum aufzunehmen. Eine potenziell fatale Malaria-Erkrankung muss bei passender Reiseanamnese sowie Fieber oder sonstigen unklaren Symptomen als Differenzialdiagnose immer in Betracht gezogen werden.
The Value of Intraoperative Magnetic Resonance Imaging in Endoscopic Endonasal Resection of Pituitary Adenoma
Authors: Patel Aneek , Dastagirzada Yosef , Benjamin Carolina , Lieberman Seth , Lebowitz Richard , Golfinos John G. , Pacione Donato 
Published: August 2022

Abstract
Background Intraoperative magnetic resonance images (iMRIs) have been variably adopted by some centers to help increase the rate of gross total resection (GTR) of pituitary adenomas. In this comparative study, we report our institution's experience with using iMRIs for endoscopic endonasal approach (EEA) pituitary adenoma resection to better elucidate its role and potential value for pituitary surgery.
Methods All adult patients who underwent EEA for a pituitary adenoma from January 2013 to September 2021 were retrospectively reviewed. GTR was defined as no residual tumor or recurrence on postoperative imaging within 6 months. Univariate analysis followed by multivariate analysis was performed with GTR as the categorical endpoint. To measure the independent effect of iMRI on GTR, propensity score matching was then performed.
Results A total of 351 pituitary adenoma patients who underwent EEA were identified. The mean age was 51.2 (range: 18–90) years and 196 (55.8%) patients were female. iMRI was utilized in 87 (24.8%) cases. The overall rate of GTR was 69.2%. On multivariate analysis, low Knosp grade, low tumor volume, and the use of iMRI were predictive of GTR. There was no difference in the need for desmopressin or hydrocortisone at 90 days postoperatively.
Conclusion At our institution, we report a significant absolute increase in GTR rates of 16.4% for patients undergoing an iMRI. Among iMRI patients who did not have GTR, the majority of residuals were intentionally left behind after being deemed too risky to pursue. Overall, this study suggests the high value that iMRI adds to endoscopic pituitary adenoma surgery.
Multifocal Small Bowel Angioectasias: Managed with Innovative, Nonresectional Surgical Procedure
Authors: Ghosh Nalini Kanta , Singh Ashish , Rahul Rahul , Singh Rajneesh Kumar , Goel Amit , Saxena Rajan 
Published: August 2022

AbstractGastrointestinal (GI) angioectasias/angiodysplasias are the most frequent vascular lesions of GI tract, responsible for ∼5 to 6% of GI bleedings. It commonly involves the small bowel, making it difficult to diagnose and manage endoscopically. Though medical management has been used to prevent bleeding, it has only a limited role in acute severe hemorrhage. In such cases, surgical resection remains the only practical option. However, multiple lesions pose a unique challenge, as resection may not be advisable for long length of bowel involvement. Here, we report a case of recurrent GI bleeding due to multifocal small bowel angioectasias who was managed by a novel technique of full-thickness transmural sutures under intraoperative enteroscopic guidance. At 6 months follow-up, no new bleeding episodes were observed.
An Unusual FDG-PET/CT Documentation in Aleukemic Leukemia Cutis: Atypical Penile, Scrotal, and Leg Muscles Involvement
Authors: Sonavane Sunita Nitin , Basu Sandip 
Published: August 2022

AbstractAleukemic leukemia cutis (ALC) is a rare condition with a relatively poor prognosis, clinically presenting as skin and subcutaneous nodules commonly involving head and neck region with discrete atypical leukemic cells infiltrating in the skin on histopathology. The lesions on the genital area skin are seldom reported. A 49-year-old male presented with joint pains and multiple subcutaneous nodules clinically with biopsy proving it as leukemia cutis. Bone marrow aspiration and biopsy were suggestive of normocellular myeloid preponderant bone marrow with mild increase in eosinophils. The 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed metabolically active FDG avid ill-defined soft tissue attenuation involving the entire length of penile shaft with central necrotic area, diffuse scrota skin thickening, and lateral compartment muscles of left leg, in addition to multiple hypermetabolic metastatic lymph nodes, and diffuse hypermetabolic marrow in humerii and femora. Despite prompt investigations and initiation of management, the patient succumbed in 15 days post-FDG PET/CT. The present report depicts an atypical case of ALC, with FDG PET-CT showing extensive and unusual sites of disease involvement, emphasizing its potential role in ALC.
Basal Ganglia Germinoma in an Adolescent: A Case Report
Authors: Kulkarni Shilpa , Ainapure Anish , Gala Foram , Shah Payal , Gavali Vrushabh 
Published: August 2022

AbstractGerm cell tumors are rare tumors and may pose a diagnostic dilemma. We present a 15-year-old boy with insidious onset right hemiparesis followed by polyuria and polydipsia. Later, he also developed cognitive decline and speech disturbances. Serial magnetic resonance images (MRIs) over a 2-year period showed progressive atrophy of the left caudate nucleus, along with Wallerian degeneration of the left internal capsule and crus of midbrain. Further in the course, imaging revealed an ill-defined signal intensity involving left ganglio-capsulo-thalamic region with increased perfusion which was suggestive of basal ganglia germinoma. Beta human chorionic gonadotropin levels were mildly elevated. This case illustrates an uncommon presentation of a central nervous system germinoma which is often misdiagnosed in the early stages because of its atypical symptomatology and MRI findings.
Seeds and the city: a review of municipal home food gardening programs in Canada in response to the COVID-19 pandemic
Authors: Music Janet , Mullins Lisa , Charlebois Sylvain , Large Charlotte , Mayhew Kydra 
Published: August 2022

AbstractIn the wake of the COVID-19 pandemic in Canada, home food gardening articles have saturated popular media outlets. Home food gardening is more popular than ever, and community gardens and community greenhouses are at capacity with long waiting lists for plots. Several local governments across the country are also participating in the food gardening craze. This study compares 19 municipal urban home food gardening programs that ran in 2020. These municipalities provided program participants with free gardening supplies and instructions on how to grow food at home. This study reveals a complicated relationship among municipalities, food gardening programs and household and community food security. The study also determines that the social and emotional challenges brought about by the COVID-19 pandemic are somewhat alleviated through gardening. Ultimately, municipalities are limited in their policy capacities to adequately move the needle on food insecurity in Canada.
Simulation of millimeter-sized microwave plasma discharge generator under various conditions
Authors: Lei Fan , Xue Yan , Liu Donglin 
Published: August 2022

A microwave plasma generator (MPG) of a sub-millimeter scale might be suitable for biomedical applications. However, there are still many unknowns regarding the MPG discharge behavior at this scale and specific conditions. A two-dimensional MPG model at the millimeter scale and its simulation and relative calculation in the COMSOL Multiphysics software are presented. A MPG filled with argon and helium is simulated, respectively. The frequency of a microwave source of about 5 GHz is considered. The number density and temperature of electrons as well as chemical composition are obtained at different power and pressure conditions. The electron density peaks slightly downstream of the crossing point, and the electron density is slightly asymmetrically in the y-plane due to the fact that the electromagnetic waves are absorbed asymmetrically. The electron temperature is relatively low everywhere, in part, due to the high operating pressure. The electron temperature peaks directly underneath the wave guide where the wave is absorbed. The electron density increases with the increase in the internal pressure and the input power of the MPG, the electron temperature decreases with the increase in the internal pressure of the MPG, but the electron temperature cannot be affected by the input power change of MPG. The amount of excited Ar+ and Ars (metastable atom) increases with the increase in the input power and pressure of MPG, but the amount of excited Ar almost remained unchanged. In addition, the amount of excited He almost remained unchanged, while the amount of excited He+, Hes (metastable atom), and He2+ increased with the increase in the input power and pressure of MPG. The simulation results of this model are thus informative for understanding the physical characteristics of millimeter-sized MPG, and it will provide a solid basis for the future development of such hardware in small plasma capsules for cancer therapy.
On the stability of a wormhole in the maximally-extended Reissner–Nordström solution
Authors: DeMott Ross , Major Sam , Flournoy Alex 
Published: August 2022

Abstract
We consider the stability of the maximally-extended Reissner–Nordström (RN) solution in a Minkowski, de Sitter, or anti-de Sitter background. In a broad class of situations, prior work has shown that spherically symmetric perturbations from a massless scalar field cause the inner horizon of an RN black hole to become singular and collapse. Even if this is the case, it may still be possible for an observer to travel through the inner horizon before it fully collapses, thus violating strong cosmic censorship. In this work, we show that the collapse of the inner horizon and the occurrence of a singularity along the inner horizon are sufficient to prevent an observer from accessing the white hole regions and the parallel Universe regions of the maximally extended RN space–time. Thus, if an observer passes through the inner horizon, they will inevitably hit the central singularity. Throughout this article, we use natural units where c = G = 4π ϵ
0 = 1.
Emergence of ferrimagnetism in Li-intercalated NiPS3
Authors: Basnet Rabindra , Ford Dawn , TenBarge Kaylee , Lochala Joshua , Hu Jin 
Published: August 2022

AbstractIntercalation has become a powerful approach to tune the intrinsic properties and introduce novel phenomena in layered materials. Intercalating van der Waals (vdW) magnetic materials is a promising route to engineer the low-dimensional magnetism. Recently, metal thiophosphates,MPX3, has been widely studied because their magnetic orders are highly tunable and persist down to the two-dimensional limit. In this work, we used electrochemical technique to intercalate Li into NiPS3single crystals and found the emergence of ferrimagnetism at low temperature in Li-intercalated NiPS3. Such tuning of magnetic properties highlights the effectiveness of intercalation, providing a novel strategy to manipulate the magnetism in vdW magnets.
Experimental optimal verification of three-dimensional entanglement on a silicon chip
Authors: Xia Lijun , Lu Liangliang , Wang Kun , Jiang Xinhe , Zhu Shining , Ma Xiaosong 
Published: August 2022

Abstract
High-dimensional entanglement is significant for the fundamental studies of quantum physics and offers unique advantages in various quantum information processing tasks. Integrated quantum devices have recently emerged as a promising platform for creating, processing, and detecting complex high-dimensional entangled states. A crucial step toward practical quantum technologies is to verify that these devices work reliably with an optimal strategy. In this work, we experimentally implement an optimal quantum verification strategy on a three-dimensional maximally entangled state using local projective measurements on a silicon photonic chip. A 95% confidence is achieved from 1190 copies to verify the target quantum state. The obtained scaling of infidelity as a function of the number of copies is −0.5497 ± 0.0002, exceeding the standard quantum limit of −0.5 with 248 standard deviations. Our results indicate that quantum state verification could serve as an efficient tool for complex quantum measurement tasks.
Simulated catalogs and maps of radio galaxies at millimeter wavelengths in Websky
Authors: Li Zack , Puglisi Giuseppe , Madhavacheril Mathew S. , Alvarez Marcelo A. 
Published: August 2022

Abstract
We present simulated millimeter-wavelength maps and catalogs of radio galaxies across the full sky that trace the nonlinear clustering and evolution of dark matter halos from the Websky simulation at z < 4.6 and M
halo > 1012
m
⊙/h, and the accompanying framework for generating a new sample of radio galaxies from any halo catalog of positions, redshifts, and masses. Object fluxes are generated using a hybrid approach that combines (1) existing astrophysical halo models of radio galaxies from the literature to determine the positions and rank-ordering of the observed fluxes with (2) empirical models from the literature based on fits to the observed distribution of flux densities and (3) spectral indices drawn from an empirically-calibrated frequency-dependent distribution. The resulting population of radio galaxies is in excellent agreement with the number counts, polarization fractions, and distribution of spectral slopes from the data from observations at millimeter wavelengths from 20-200 GHz, including Planck, ALMA, SPT, and ACT. Since the radio galaxies are correlated with the existing cosmic infrared background (CIB), Compton-y (tSZ), and CMB lensing maps from Websky, our model makes new predictions for the cross-correlation power spectra and stacked profiles of radio galaxies and these other components. These simulations will be important for unbiased analysis of a wide variety of observables that are correlated with large-scale structure, such as gravitational lensing and SZ clusters.
Ultra-efficient DC-gated all-optical graphene switch
Authors: Alaloul Mohammed , As’ham Khalil , Hattori Haroldo T , Miroshnichenko Andrey E 
Published: August 2022

Abstract
The ultrafast response and broadband absorption of all-optical graphene switches are highly desirable features for on-chip photonic switching. However, because graphene is an atomically thin material, its absorption of guided optical modes is relatively low, resulting in high saturation thresholds and switching energies for these devices. To boost the absorption of graphene, we present a practical design of an electrically-biased all-optical graphene switch that is integrated into silicon slot waveguides, which strongly confine the optical mode in the slotted region and enhance its interaction with graphene. Moreover, the design incorporates a silicon slab layer and a hafnia dielectric layer to electrically tune the saturation threshold and the switching energy of the device by applying direct-current voltages of

<

0.5 V. Using this device, a high extinction ratio of 10.3 dB, a low insertion loss of

<

0.7 dB, and an ultra-efficient switching energy of 79 fJ/bit at 0.23 V bias are attainable for a 40 µm long switch. The reported performance metrics for this device are highly promising and are expected to serve the needs of next-generation photonic computing systems.