bluuebunny/crossref_metadata_2025_split huggingface dataset:
TTOP‐model‐based maps of permafrost distribution in Northeast China for 1961–2020
Authors: Li Xiaoying , Jin Huijun , Sun Long , Wang Hongwei , Huang Yadong , He Ruixia , Chang Xiaoli , Yu Shaopeng , Zang Shuying 
Published: July 2022

AbstractNortheast China has experienced rapid and substantial climate warming over the past 60 years, and permafrost is degrading rapidly. In this study, permafrost distribution and extent in Northeast China were estimated from monitored ground surface temperatures using the temperature at the top of permafrost (TTOP) model and geographically weighted regression method. Using the TTOP model, the computed mean annual ground temperatures (MAGT@TOP) at the top of permafrost of Northeast China increased significantly from 1961–1990 (1.8°C) to 1991–2020 (3.0°C). The areal extents of permafrost defined by a subzero MAGT@TOP (MAGT@TOP ≤ 0°C) in Northeast China in the period 1961–1990 and 1991–2020 were estimated at 461.5 × 103 and 365.8 × 103 km2, respectively, indicating a decline of 95.7 × 103 km2. On average, the simulated MAGT@TOP values were 2.07°C lower than the observed MAGT@TOP values in boreholes. The linear correlation coefficient between the simulated and measured MAGT@TOP values was 0.63. Compared with the simulation results of other previous models, the result of this research is more reliable and accurate. The compiled maps of permafrost distribution can serve as an important reference for the study of permafrost changes in Northeast China.
Exploring the effects of mutations on NFAT5‐DNA binding using molecular dynamics simulations and energy calculations
Authors: Li Yufei , Chen Lin , Han Zhisen , Na Jingyun , Wang Ruige , Jing Tao , Zhao Bing 
Published: July 2022

AbstractNFAT5, an activated T‐cell factor, plays a regulatory role in a variety of autoimmune processes through specific recognition with DNA. However, the details of the interaction of NFAT5 with DNA are unclear. Focused on the complexes of wild type (WT) and mutant NFAT5 with DNA complexes, respectively, we have conducted research on the conformational and dynamics effects caused by residue mutations through molecular dynamics (MD) simulations combined with MM‐PBSA prediction. According to the results of MM‐PBSA, non‐polar interactions are the main driving force in the interaction between NFAT5 and DNA. At the same time, 26 residues play a key role in the interaction with DNA. The energy decomposition results suggest that extensive interactions between the nitrogenous bases of DNA and NFAT5 are responsible for the specific recognition of DNA by NFAT5. By superimposing the structures of mutants and WT complexes, it was found that mutations not only affect the mutated residues, but also change the binding contribution of other amino acids, hydrogen bonding interactions and the stability of the complexes. These results provide a strong rationale and new ideas for NFAT5 as a new target for the treatment of autoimmune diseases.
Distributed optimal event‐triggered cooperative control for nonlinear multi‐missile guidance systems with partially unknown dynamics
Authors: Gao Yuxin , Liu Chunsheng , Duan Dandan , Zhang Shaojie 
Published: July 2022

AbstractThis article is concerned with the design of a novel distributed optimal event‐triggered (ET) cooperative control strategy for nonlinear multi‐missile guidance systems under the condition of partially unknown dynamics via adaptive dynamics programming. First, an improved online‐identifier is proposed to reconstruct the unknown dynamics based on the data‐driven mechanism in which an adaptive compensation term is introduced. The identification residual error is counteracted and the priori identification information is not required. In order to solve the Hamilton–Jacobi–Bellman equation, a single critic neural network (CNN) is utilized to approximate the online solutions and helps calculate the control policy. Then, the uniformly ultimately bounded for the ET closed‐loop system and the CNN weight error are proved by utilizing Lyapunov theory. Finally, the application to the multi‐missile guidance systems with simultaneous impact consideration validates all missiles can hit the target simultaneously and indicates the effectiveness of the designed approach.
A Series of Novel Bioactive Cyclic Peptides: Synthesis by Head‐to‐Tail Cyclization Approach, Antimicrobial Activity and Molecular Docking Studies
Authors: Tivari Sunil R. , Kokate Siddhant V. , Sobhia Elizabeth M. , Kumar Siva G. , Shelar Uttam B. , Jadeja Yashwantsinh S. 
Published: July 2022

AbstractA new series of cyclic antimicrobial peptides (AMPs) containing D/L‐α‐amino acids have been designed and characterized by spectroscopic techniques. Newly synthesized cyclic peptides were tested for antibacterial and antifungal activities in the hopes of discovering novel clues that may be used to create effective anti‐microbial medicine. Those cyclic AMPs demonstrated good antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and that was comparable to reference drug Imipenem, as well as good antifungal activity against microbial strains Aspergillus Flavus, Candida Albicans and Candida GlabarataI that was comparable to reference drug Miconazole. In continuous, molecular docking study of the targeted cyclic peptides revealed that they exhibited promising binding interaction networks with DNA gyrase and lanosterol‐14 alpha demethylase, which showed the correlation between biologic activity and docking score of the synthesized analogs.
Fe‐doped Nickel Carbonate Hydroxide Array Electrocatalysts for Enhanced Oxygen Evolution Reaction
Authors: Tian Zhangmin , Peng Bin , Yang Jianing , Shi Yingying , Ma Chenxu , Liu Guiying , Zheng Wenjun 
Published: July 2022

AbstractDeveloping efficient and inexpensive oxygen evolution reaction (OER) electrocatalysts is crucial to address the ever‐increasing energy crisis and environment pollution. In this work, bimetallic nickel‐iron carbonate hydroxide arrays were strongly grown on a conductive carbon cloth (NiFeCH/CC) through a facile one‐step hydrothermal method, which were used as oxygen evolution reaction (OER) electrocatalysts. Ni0.8Fe0.2CH/CC requires overpotential of just 246 mV at 10 mA cm−2, Tafel slope of 43 mV dec−1, and charge transfer resistance of 3.1 Ω for OER in 1 M KOH. The catalyst also shows excellent durability by a long‐term operation for 10 h. A post‐OER study of Ni0.8Fe0.2CH/CC reveals that the NiFeOOH species form on the surface during OER and the carbonate ions still intercalate between the cationic layers. Benefiting from a three‐dimensional structure and Fe doping strategy, the performance of Ni0.8Fe0.2CH/CC has been improved. This work provides an effective strategy to design efficient OER electrocatalysts in alkaline media.
Association between abnormal brain oscillations and cognitive performance in patients with bipolar disorder: Molecular mechanisms and clinical evidence
Authors: Lu Zhou , Wang Huixiao , Gu Jiajie , Gao Feng 
Published: July 2022

AbstractBrain oscillations have gained great attention in neuroscience during recent decades as functional building blocks of cognitive‐sensory processes. Research has shown that oscillations in “alpha,” “beta,” “gamma,” “delta,” and “theta” frequency windows are highly modified in brain pathology, including in patients with cognitive impairment like bipolar disorder (BD). The study of changes in brain oscillations can provide fundamental knowledge for exploring neurophysiological biomarkers in cognitive impairment. The present article reviews findings from the role and molecular basis of abnormal neural oscillation and synchronization in the symptoms of patients with BD. An overview of the results clearly demonstrates that, in cognitive‐sensory processes, resting and evoked/event‐related electroencephalogram (EEG) spectra in the delta, theta, alpha, beta, and gamma bands are abnormally changed in patients with BD showing psychotic features. Abnormal oscillations have been found to be associated with several neural dysfunctions and abnormalities contributing to BD, including abnormal GABAergic neurotransmission signaling, hippocampal cell discharge, abnormal hippocampal neurogenesis, impaired cadherin and synaptic contact‐based cell adhesion processes, extended lateral ventricles, decreased prefrontal cortical gray matter, and decreased hippocampal volume. Mechanistically, impairment in calcium voltage‐gated channel subunit alpha1 I, neurotrophic tyrosine receptor kinase proteins, genes involved in brain neurogenesis and synaptogenesis like WNT3 and ACTG2, genes involved in the cell adhesion process like CDH12 and DISC1, and gamma‐aminobutyric acid (GABA) signaling have been reported as the main molecular contributors to the abnormalities in resting‐state low‐frequency oscillations in BD patients. Findings also showed the association of impaired synaptic connections and disrupted membrane potential with abnormal beta/gamma oscillatory activity in patients with BD. Of note, the synaptic GABA neurotransmitter has been found to be a fundamental requirement for the occurrence of long‐distance synchronous gamma oscillations necessary for coordinating the activity of neural networks between various brain regions.
On (g − 2)μ from gauged U(1)X
Authors: Greljo Admir , Stangl Peter , Thomsen Anders Eller , Zupan Jure 
Published: July 2022

Abstract
We investigate an economical explanation for the (g − 2)μ anomaly with a neutral vector boson from a spontaneously broken U(1)X gauge symmetry. The Standard Model fermion content is minimally extended by 3 right-handed neutrinos. Using a battery of complementary constraints, we perform a thorough investigation of the renormalizable, quark flavor-universal, vector-like U(1)X models, allowing for arbitrary kinetic mixing. Out of 419 models with integer charges not greater than ten, only 7 models are viable solutions, describing a narrow region in model space. These are either Lμ− Lτ or models with a ratio of electron to baryon number close to −2. The key complementary constraints are from the searches for nonstandard neutrino interactions. Furthermore, we comment on the severe challenges to chiral U(1)X solutions and show the severe constraints on a particularly promising such candidate.
Antibacterial properties and abrasion-stability: Development of a novel silver-compound material for orthodontic bracket application
Authors: Denis Hannah , Werth Richard , Greuling Andreas , Schwestka-Polly Rainer , Stiesch Meike , Meyer-Kobbe Viktoria , Doll Katharina 
Published: July 2022

Abstract
Purpose
Bacteria-induced white spot lesions are a common side effect of modern orthodontic treatment. Therefore, there is a need for novel orthodontic bracket materials with antibacterial properties that also resist long-term abrasion. The aim of this study was to investigate the abrasion-stable antibacterial properties of a newly developed, thoroughly silver-infiltrated material for orthodontic bracket application in an in situ experiment.

Methods
To generate the novel material, silver was vacuum-infiltrated into a sintered porous tungsten matrix. A tooth brushing simulation machine was used to perform abrasion equal to 2 years of tooth brushing. The material was characterized by energy dispersive X‑ray (EDX) analysis and roughness measurement. To test for antibacterial properties in situ, individual occlusal splints equipped with specimens were worn intraorally by 12 periodontal healthy patients for 48 h. After fluorescence staining, the quantitative biofilm volume and live/dead distribution of the initial biofilm formation were analyzed by confocal laser scanning microscopy (CLSM).

Results
Silver was infiltrated homogeneously throughout the tungsten matrix. Toothbrush abrasion only slightly reduced the material’s thickness similar to conventional stainless steel bracket material and did not alter surface roughness. The new silver-modified material showed significantly reduced biofilm accumulation in situ. The effect was maintained even after abrasion.

Conclusion
A promising, novel silver-infiltrated abrasion-stable material for use as orthodontic brackets, which also exhibit strong antibacterial properties on in situ grown oral biofilms, was developed. The strong antibacterial properties were maintained even after surface abrasion simulated with long-term toothbrushing.
Long-term follow-up of patients undergoing renal sympathetic denervation
Authors: Zeijen Victor J. M. , Feyz Lida , Nannan Panday Rajiv , Veen Kevin , Versmissen Jorie , Kardys Isabella , Van Mieghem Nicolas M. , Daemen Joost 
Published: July 2022

Abstract
Objectives
Renal denervation (RDN) proved to significantly lower blood pressure (BP) at 2–6 months in patients on and off antihypertensive drugs. Given a lack of longer-term follow-up data, our aim was to assess the safety and efficacy of RDN up to five years taking into account antihypertensive drug regimen changes over time.

Methods
In the present single-center study, patients underwent RDN for (therapy resistant) hypertension. Patients underwent protocolized yearly follow-up out to five years. Data were collected on 24-h ambulatory BP and office BP monitoring, renal function, antihypertensive drug regimen, and safety events, including non-invasive renal artery imaging at 6/12 months. Efficacy analyses were performed using linear mixed-effects models.

Results
Seventy-two patients with mean age 63.3 ± 9.5 (SD) years (51% female) were included. Median follow-up time was 3.5 years and Clark’s Completeness Index was 72%. Baseline ambulatory daytime BP was 146.1/83.7 ± 17.4/12.2 mmHg under a mean number of 4.9 ± 2.7 defined daily doses (DDD). At five years, ambulatory daytime systolic BP as calculated from the mixed model was 120.8 (95% CI 114.2–127.5) mmHg and diastolic BP was 73.3 (95% CI 69.4–77.3) mmHg, implying a reduction of -20.9/-8.3 mmHg as compared to baseline estimates (p < 0.0001). The number of DDDs remained stable over time (p = 0.87). No procedure-related major adverse events resulting in long-term consequences were observed.

Conclusions
The BP-lowering effect of RDN was safely maintained at least five years post-procedure as reflected by a significant decrease in ambulatory daytime BP in the absence of escalating antihypertensive drug therapy over time.

Graphical abstract
Outcomes of distal ulna locking plate in management of unstable distal ulna fractures: a prospective case series
Authors: Stock K. , Benedikt S. , Kastenberger T. , Kaiser P. , Arora R. , Zelger P. , Pallua J. D. , Schmidle G. 
Published: July 2022

Abstract
Introduction
Given the absence of a satisfying plate system to deal with multifragmentary or subcapital distal ulnar fractures, the Distal Ulna Locking Plate (DUL, I.T.S. GmbH, Graz, Austria) could become a useful treatment option. This study aimed to evaluate the results of this anatomically pre-contoured plate regarding patients with unstable or displaced distal ulnar fractures.

Methods
In a prospective clinical trial, 20 patients (18 female, two male; mean age 70 years (24–91 years)) with unstable or displaced distal ulna fractures between December 2010 and August 2015 were analyzed. All patients were treated with open reduction and internal fixation using the DUL. They were evaluated at three follow-up appointments at 3, 6 and 12 months postoperatively regarding their bone healing, ulnar variance (UV), range of motion (ROM) and grip strength. Patient related outcomes were measured using the Disability of the Arm, Shoulder and Hand (DASH), the Patient Rated Wrist Evaluation (PRWE) questionnaires, and the Visual Analogue Scale (VAS). The results after one year were compared to the outcome of the healthy contralateral side.

Results
All fractures treated with open reduction and internal fixation using the Distal Ulna Locking Plate healed within 6 months and showed stable ulnar variances after surgery. ROM (rotational plane 81.1 ± 9.0°, sagittal plane 55.1 ± 14.6°, frontal plane 33.0 ± 9.4°) and grip strength (18.7 ± 7.1 N) at the follow-up after 12 month had similar values compared with the uninjured side. The mean DASH score (36.4 ± 29.0), the PRWE-score (14.5 ± 27.0), and the VAS (at rest 0.5 ± 1.1, during activity 1.2 ± 2.4) after one year had no significant difference to the uninjured side. The surgeon’s overall satisfaction rate regarding plate handling reached 81.8%.

Conclusion
Stabilization of unstable distal ulna fractures using the DUL restores nearly normal anatomy and function. Its pre-countered design, volar placement, and enhanced stability present a satisfying plate system.

Trial registration
The trial was retrospectively Registered at www.clinicaltrials.gov on 16 December 2021 (Trial Registration Number: NCT05329012).
Hands-on false memories: a combined study with distributional semantics and mouse-tracking
Authors: Gatti Daniele , Marelli Marco , Mazzoni Giuliana , Vecchi Tomaso , Rinaldi Luca 
Published: July 2022

AbstractAlthough mouse-tracking has been seen as a real-time window into different aspects of human decision-making processes, currently little is known about how the decision process unfolds in veridical and false memory retrieval. Here, we directly investigated decision-making processes by predicting participants’ performance in a mouse-tracking version of a typical Deese–Roediger–McDermott (DRM) task through distributional semantic models, a usage-based approach to meaning. Participants were required to study lists of associated words and then to perform a recognition task with the mouse. Results showed that mouse trajectories were extensively affected by the semantic similarity between the words presented in the recognition phase and the ones previously studied. In particular, the higher the semantic similarity, the larger the conflict driving the choice and the higher the irregularity in the trajectory when correctly rejecting new words (i.e., the false memory items). Conversely, on the temporal evolution of the decision, our results showed that semantic similarity affects more complex temporal measures indexing the online decision processes subserving task performance. Together, these findings demonstrate that semantic similarity can affect human behavior at the level of motor control, testifying its influence on online decision-making processes. More generally, our findings complement previous seminal theories on false memory and provide insights into the impact of the semantic memory structure on different decision-making components.
Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells
Authors: González-Bermúdez Lourdes , Genescà Anna , Terradas Mariona , Martín Marta 
Published: July 2022

AbstractIncreased frequency of DNA double strand breaks (DSBs) with aging suggests an age-associated decline in DSB repair efficiency, which is also influenced by the epigenetic landscape. H4 acetylation at lysine 16 (H4K16Ac) has been related to DSB repair since deacetylation of this mark is required for efficient 53BP1 recruitment to DSBs. Although age-associated changes in H4K16Ac levels have been studied, their contribution to age-related DSB accumulation remains unknown. In vitro aged Human Dermal Fibroblasts (HDFs) display lower levels of H4K16A that correlate with reduced recruitment of 53BP1 to basal DSBs. Following DNA damage induction, early passage (EP) cells suffered from a transient H4K16 deacetylation that allowed proper 53BP1 recruitment to DSBs. In contrast, to reach this specific and optimum level, aged cells responded by increasing their overall lower H4K16Ac levels. Induced hyperacetylation of late passage (LP) cells using trichostatin A increased H4K16Ac levels but did not ameliorate 53BP1 recruitment. Instead, deacetylation induced by MOF silencing reduced H4K16Ac levels and compromised 53BP1 recruitment in both EP and LP cells. Age-associated decrease of H4K16Ac levels contributes to the repair defect displayed by in vitro aged cells. H4K16Ac responds to DNA damage in order to reach a specific, optimum level that allows proper 53BP1 recruitment. This response may be compromised with age, as LP cells depart from lower H4K16Ac levels. Variations in H4K16Ac following the activation of the DNA damage response and aging point at this histone mark as a key mediator between DNA repair and age-associated chromatin alterations.
Social norms explain prioritization of climate policy
Authors: Cole Jennifer C. , Ehret Phillip J. , Sherman David K. , Van Boven Leaf 
Published: July 2022

AbstractMost people in the United States recognize the reality of climate change and are concerned about its consequences, yet climate change is a low priority relative to other policy issues. Recognizing that belief in climate change does not necessarily translate to prioritizing climate policy, we examine psychological factors that may boost or inhibit prioritization. We hypothesized that perceived social norms from people’s own political party influence their climate policy prioritization beyond their personal belief in climate change. In Study 1, a large, diverse sample of Democratic and Republican participants (N = 887) reported their prioritization of climate policy relative to other issues. Participants’ perceptions of their political ingroup’s social norms about climate policy prioritization were the strongest predictor of personal climate policy prioritization—stronger even than participants’ belief in climate change, political orientation, environmental identity, and environmental values. Perceptions of political outgroup norms did not predict prioritization. In Study 2 (N = 217), we experimentally manipulated Democratic and Republican descriptive norms of climate policy prioritization. Participants’ prioritization of climate policy was highest when both the political ingroup and the outgroup prioritized climate policy. Ingroup norms had a strong influence on personal policy prioritization whereas outgroup norms did not. These findings demonstrate that, beyond personal beliefs and other individual differences, ingroup social norms shape the public’s prioritization of climate change as a policy issue.
Bank capital buffer releases, public guarantee programs, and dividend bans in COVID-19 Europe: an appraisal
Authors: Matyunina Alexandra , Ongena Steven 
Published: July 2022

AbstractWe analyse the recent policy decisions made by the European Central Bank and the national authorities related to capital and shareholders’ remuneration aimed at promoting banking credit supply in COVID-19-afflicted economies. We forecast the impact of the regulatory decisions based on the empirical literature and discuss the factors that reduce the banks’ incentives to expand their loan portfolios. We argue that the introduction of the dividend ban caused a surge in regulatory uncertainty and undermined banks’ market valuation raising the expected funding costs and contributing to the banks’ reluctance to make use of the capital buffers. We develop policy suggestions intended to mitigate this effect.