bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Brazilian catchments gaining or losing water? The effective area of tropical catchments
Authors: Schwamback Dimaghi , Gesualdo Gabriela C. , Sone Jullian S. , Kobayashi Alex Naoki A. , Bertotto Luis Eduardo , Garcia Maria Vitória S. , Almagro André , Oliveira Paulo Tarso S. 
Published: February 2022

AbstractSimilar to most countries, the Brazilian water resources management considers topographically delineated catchment as a territorial unit for policy implementation. Yet, previous studies have shown that catchments are not hydrologically isolated, and topographic limits often neglect the groundwater boundaries. Thus, studies on effective catchment areas are promising for shedding light on inter‐catchment groundwater flow. Here, we investigated the deviation between the topographic and effective areas across Brazil. We applied the effective catchment area index (ECI) to 733 Brazilian catchments and identified the most influencing attributes on the ECI by using principal component and random forest analyses (PCA and RFA, respectively). Further analysis was carried out by contrasting the ECI values against the expected range of the Budyko curve, considering both topographic and effective catchment areas (classic and adjusted framework, respectively). We noted that nearly 32% of the Brazilian catchments presented more than 30% of difference between the effective area and its topographic boundaries. In general, the more arid biomes in Brazil—the Cerrado and Caatinga—are prone to have smaller effective areas while larger effective areas were mostly found in the Atlantic Forest biome, a humid tropical region with a higher mean elevation. Our findings indicate that the aridity index was the main driving factor and negatively correlated with ECI followed by mean slope, precipitation seasonality, and mean elevation. We highlight the potential of adopting a pooling of catchments based on their interconnectivity to minimize management costs while maximizing synergies and lessening trade‐offs between ecosystem functioning and water transfer processes. Our results contribute to a better country‐wide understanding of hydrological connectivity among catchments and highlight the need to consider the effective catchment area to overcome water‐food‐energy security challenges on multiple scales.
Marine macroalgae as a feasible and complete resource to address and promote Sustainable Development Goals (SDGs)
Authors: García-Poza Sara , Pacheco Diana , Cotas João , Marques João C. , Pereira Leonel , Gonçalves Ana M. M. 
Published: February 2022

Abstract
Because the world's population is increasing, science-based policies are needed to promote sustainable global development. It is important to maintain and restore the environment and help human society overcome the risks from industrialization and unsustainable exponential growth. In recent years, many studies have highlighted that macroalgae represent a key marine resource for ecological and sustainable living, thus helping to address today's global problems, such as water pollution, ocean acidification, and global warming. Macroalgae show the potential to provide innovative, ecofriendly, and nutritious food sources and natural compounds for various industries, such as biomedical, food, agricultural, and pharmaceutical industries. This review discusses how macroalgae can help us today and how they can promote a more sustainable way of life in the future. It also discusses the potential danger for ecosystems and the global population if these organisms are not part of the solution but part of the problem. Integr Environ Assess Manag 2022;18:1148–1161. © 2022 SETAC
KEY POINTS
Macroalgae can play a fundamental role in the development of compliance within the SDGs. On an ecological scale and referring to coastal and oceanic habitats, macroalgae have a key role, because not only do they represent unique nursery areas with a high ecological relevance, but they are also agents for the removal of inorganic pollutants, thus contributing to water bioremediation. Macroalgae endorse complex food webs in marine habitats and act as a coastal defense by damping waves’ energy; moreover, they contribute to carbon dioxide sequestration, minimizing our carbon footprint and mitigating climate change impacts, as they are photosynthetic organisms. Macroalgae aquaculture can help to reduce the effects of ocean acidification while responding to the global need of feed, fuel, pharmaceuticals, and food by becoming a source to combat malnutrition.
A Review of Big Data Research in Accounting
Authors: Aboagye‐Otchere Francis , Agyenim‐Boateng Cletus , Enusah Abdulai , Aryee Theodora Ekua 
Published: February 2022

SummaryThe impending fourth industrial revolution has enhanced the role of big data analytics in today’s business practice. Consequently, many now consider big data as the most strategic resource in business to the extent that organizations that fail to utilize it may become competitively disadvantaged. Following these developments, questions have been raised about the future of the accounting discipline, especially in terms of how it can continue to add value to organizations. While some scholars have attempted to address this question, it remains an abstract concept requiring further investigation. Therefore, this study conducts a systematic literature review to determine the status of accounting research on big data analytics and provides avenues for further studies. By conducting co‐occurrence network analysis on 52 peer‐reviewed articles published from 2010 to 2020, three broad themes emerged, entailing big data implications for accounting practice, education, and research design. A further examination of the themes revealed few empirical studies on the phenomenon, as conceptual research dominates the field. Although external audit implications of big data are widely discussed, other accounting domains (e.g., managerial accounting and taxation) are underexplored. Therefore, future studies may focus on the implications of big data on variables such as performance measurement, information governance, tax behavior, curriculum design, and pedagogy.
Effects of bone marrow‐derived mesenchymal stem cells on doxorubicin‐induced liver injury in rats
Authors: Celik Samanci Tugba , Gökcimen Alpaslan , Kilic Eren Mehtap , Gürses Kadri Murat , Pilevneli Hatice , Kuyucu Yurdun 
Published: February 2022

AbstractDoxorubicin (DOX) is a potent chemotherapeutic agent and has toxic effects on various organs, including the liver. In the current study, we aimed to investigate the effects of bone‐marrow‐derived mesenchymal stem cell (BM‐MSC) administration on DOX‐induced hepatotoxicity in rats. 24 Wistar‐albino rats were divided into three groups: Control, DOX, and DOX+MSC. DOX (20 mg/kg) was administered to the DOX group. In the DOX + MSC group, BM‐MSCs (2 × 106) were given through the tail vein following DOX administration. DOX administration led to significant structural liver injury. Besides this, oxidative balance in the liver was impaired following DOX administration. DOX administration also led to an increase in apoptotic cell death in the liver. Structural and oxidative changes were significantly alleviated with the administration of BM‐MSCs. Furthermore, BM‐MSC administration suppressed excessive apoptotic cell death. Our findings revealed that BM‐MSC administration may alleviate DOX‐induced liver injury via improving the oxidative status and limiting apoptotic cell death in the liver tissue.
Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α‐glycosidase
Authors: Tezcan Burcu , Gök Yetkin , Sevinçek Resul , Taslimi Parham , Taskin‐Tok Tugba , Aktaş Aydın , Güzel Bilgehan , Aygün Muhittin , Gülçin İlhami 
Published: February 2022

AbstractHere, we report the synthesis, characterization, and biological activities of a series of benzimidazolium salts bearing the trifluoromethylbenzyl group. All benzimidazolium salts were characterized by using nuclear magnetic resonance (NMR) (1H NMR and 13C NMR), Fourier transform‐infrared spectroscopy, and elemental analysis techniques. The crystal structures of some of these compounds were obtained by the single‐crystal X‐ray diffraction method. Furthermore, the acetylcholinesterase (AChE) and α‐glycosidase (α‐Gly) enzyme inhibition activities of these compounds were investigated. The obtained results revealed that2e, withKivalue of 1.36 ± 0.34 µM against AChE and3dwithKivalue of 91.37 ± 10.38 µM against α‐Gly, were the most potent compounds against both assigned enzymes. It should be noted that most of the synthesized compounds were more potent than standard inhibitor tacrine (TAC) against AChE. In silico studies, we focused on compound2e, 3d, 3e, and3fas potent inhibitors of AChE and α‐Gly, the compound2eshowed good binding energy (−10.23 kcal/mol), among the three selected compounds and positive control (−10.18, −10.08, and −7.37 kcal/mol for3d, 3f, and TAC, respectively). Likewise, as a result of the same compounds against the α‐Gly enzyme, the compound3dhad the highest binding affinity (−8.39 kcal/mol) between the four selected compounds and the positive control (−8.27, −8.10, −8.06, and −7.53 kcal/mol for3f, 3e, 2e, and acarbose, respectively). From the absorption, distribution, metabolism, excretion, and toxicity analyses, it can be concluded that the compounds under consideration exhibited more drug‐likeness properties in the prediction studies compared to positive controls.
Human outgrowth knee fibroblasts from patients undergoing total knee arthroplasty exhibit a unique gene expression profile and undergo myofibroblastogenesis upon TGFβ1 stimulation
Authors: Bayram Banu , Thaler Roman , Bettencourt Jacob W. , Limberg Afton K. , Sheehan Kevin P. , Owen Aaron R. , Berry Daniel J. , Morrey Mark E. , Sanchez‐Sotelo Joaquin , van Wijnen Andre J. , Dudakovic Amel , Abdel Matthew P. 
Published: February 2022

AbstractArthrofibrosis is characterized by excessive extracellular matrix (ECM) deposition that results in restricted joint motion after total knee arthroplasties (TKAs). Currently, treatment options are limited. Therefore, an in vitro model of knee‐related myofibroblastogenesis is valuable to facilitate investigation of the arthrofibrotic process, diagnostic and therapeutic options. In this study, we obtained intraoperative posterior capsule (PC), quadriceps tendon (QT), and suprapatellar pouch (SP) tissues from the knees of four patients undergoing primary TKAs for osteoarthritis. From these tissues, we isolated primary cells by the outgrowth method and subsequently characterized these cells in the absence and presence of the pro‐myofibroblastic cytokine, transforming growth factor beta 1 (TGFβ1). Light microscopy of knee outgrowth cells revealed spindle‐shaped cells, and immunofluorescence (IF) analysis demonstrated staining for the fibroblast‐specific markers TE‐7 and vimentin (VIM). These knee outgrowth fibroblasts differentiated readily into myofibroblasts as reflected by enhanced α‐smooth muscle actin (ACTA2) mRNA and protein expression and increased mRNA expression of collagen type 1 (COL1A1) and type 3 (COL3A1) with collagenous matrix deposition in the presence of TGFβ1. Outgrowth knee fibroblasts were more sensitive to TGFβ1‐mediated myofibroblastogenesis than adipose‐derived mesenchymal stromal/stem cells (MSCs). While outgrowth knee fibroblasts isolated from three anatomical regions in four patients exhibited similar gene expression, these cells are distinct from other fibroblastic cell types (i.e., Dupuytren's fibroblasts) as revealed by RNA‐sequencing. In conclusion, our study provides an in vitro myofibroblastic model of outgrowth knee fibroblasts derived from patients undergoing primary TKA that can be utilized to study myofibroblastogenesis and assess therapeutic strategies for arthrofibrosis.
Thermal tolerance and acclimation capacity in the European common frog (Rana temporaria) change throughout ontogeny
Authors: Ruthsatz Katharina , Dausmann Kathrin H. , Peck Myron A. , Glos Julian 
Published: February 2022

AbstractPhenotypic plasticity may allow ectotherms with complex life histories such as amphibians to cope with climate‐driven changes in their environment. Plasticity in thermal tolerance (i.e., shifts of thermal limits via acclimation to higher temperatures) has been proposed as a mechanism to cope with warming and extreme thermal events. However, thermal tolerance and, hence, acclimation capacity, is known to vary with life stage. Using the common frog (Rana temporaria) as a model species, we measured the capacity to adjust lower (CTmin) and upper (CTmax) critical thermal limits at different acclimation temperatures. We calculated the acclimation response ratio as a metric to assess the stage‐specific acclimation capacity at each of seven consecutive ontogenetic stages and tested whether acclimation capacity was influenced by body mass and/or age. We further examined how acclimation temperature, body mass, age, and ontogenetic stage influenced CTminand CTmax. In the temperate population ofR. temporariathat we studied, thermal tolerance and acclimation capacity were affected by the ontogenetic stage. However, acclimation capacity at both thermal limits was well below 100% at all life stages tested. The lowest and highest acclimation capacity in thermal limits was observed in young and late larvae, respectively. The relatively low acclimation capacity of young larvae highlights a clear risk of amphibian populations to ongoing climate change. Ignoring stage‐specific differences in thermal physiology may drastically underestimate the climate vulnerability of species, which will hamper successful conservation actions.
Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish
Authors: Zhu Huihui , Zhang Xiaoyi , Xu Shifan , Wu Jiawen , Hou Mengying , Zhao Haobin , Zhou Qingchun , Zhong Xueping 
Published: February 2022

AbstractActivating transcription factor 5 (Atf5) is a member of the ATF/CREB family of transcription factors and involved in diverse cellular functions and diseases in mammals. However, the function of atf5 remains largely unknown in fish. Here, we report the expression pattern and function of duplicated atf5 genes in zebrafish. The results showed that the gene structures of zebrafish atf5a and atf5b were similar to their mammalian orthologs. Zebrafish Atf5a and Atf5b shared an amino acid sequence identity of 40.7%. Zebrafish atf5a and atf5b had maternal origin with dynamic expression during embryonic development. Zebrafish atf5a mRNA is mainly enriched in olfactory epithelium, midbrain, and hindbrain, while zebrafish atf5b mRNA is mainly detected in midbrain, hindbrain, and liver during embryogenesis. The results of acute hypoxia experiment showed that atf5a mRNA was significantly upregulated in the brain, liver, and muscle, while atf5b mRNA was just increased significantly in the brain. Functional analysis showed that knockdown of atf5a affects the development of the ciliated neurons in zebrafish embryos. The effect was enhanced when atf5a MO was co‐injected with atf5b MO. The development of ciliated neurons in zebrafish embryos was not affected by injection of atf5b MO alone. atf5a knockdown also affects the development of early‐born olfactory neurons. The effects caused by atf5a knockdown could be rescued by atf5b mRNA. These results suggest that the duplicated atf5 genes may have evolved divergently and play redundant biological roles in the development of olfactory sensory neurons in zebrafish.
Size and shape of the semicircular canal of the inner ear: A new marker of pig domestication?
Authors: Evin Allowen , David Loïc , Souron Antoine , Mennecart Bastien , Orliac Maeva , Lebrun Renaud 
Published: February 2022

AbstractDomestication has led to many changes in domestic animal biology, including their anatomy. The shape of the inner ear, part of the mammalian ear, has been found particularly relevant for discriminating domesticated species, their hybrids or differentiating the wild and domestic populations of a single species. Here we assessed the use of the size and shape of the semicircular canals (SCC) of the inner ear as a marker of pig domestication. We studied a total of 63 petrosal bones belonging to wild boar (Sus scrofa, two populations) and domestic pigs (extensively and intensively reared specimens) that were µCT‐scanned and from which the size and the shape of the inner ear were quantified through geometric morphometrics, analyzing the 3D coordinates of 6 landmarks and 60 sliding semilandmarks localized on the SCC and the common crus. The domestic pigs have larger SCC than the wild boar from which they also strongly differ in shape (correct cross validation of 95.5%, confidence interval: 92.3%–98.1%). Strong shape differences were detected between the two populations of wild boar, as well as a sexual size dimorphism. All together the results highlight the taxonomic discriminant power of the SCC of the inner ear shape, and its relevance for domestication studies.
Counting spanning trees in a complete bipartite graph which contain a given spanning forest
Authors: Dong Fengming , Ge Jun 
Published: February 2022

AbstractIn this article, we extend Moon's classic formula for counting spanning trees in complete graphs containing a fixed spanning forest to complete bipartite graphs. Let be the bipartition of the complete bipartite graph with and . We prove that for any given spanning forest of with components , the number of spanning trees in which contain all edges in is equal to
where and for .
Geochemical focusing and burial of sedimentary iron, manganese, and phosphorus during lake eutrophication
Authors: Scholtysik Grzegorz , Goldhammer Tobias , Arz Helge W. , Moros Matthias , Littke Ralf , Hupfer Michael 
Published: February 2022

AbstractThe redistributive transport of sedimentary, redox‐sensitive metals such as iron (Fe) and manganese (Mn) along depth gradients in lakes or marine basins, and in particular the concentration of these elements at local depressions, has been described as “geochemical focusing.” However, the impact of variable redox conditions at the sediment–water interface on this process is not entirely understood. In this study, we report that the enrichment and burial of Fe, Mn, and associated phosphorus (P) in dimictic Lake Arendsee, Germany, has been affected by a transition from oligo‐mesotrophic to eutrophic conditions in the first half of the 20th century. Eleven sediment cores (<50 cm long) were obtained from water depths ranging from 38.5 to 49.5 m, and analyzed for their elemental composition. The older, non‐varved section, which was deposited prior ca. 1940 during oligo‐mesotrophic conditions, contains up to 10 times higher Mn and 2.5 times higher Fe contents at the deep sites compared to corresponding intervals at shallower sites. Due to their high Fe content, sediments in this interval also contain up to eight times more P, at least partly owing to vivianite authigenesis. Burial of Mn occurred via Mn‐carbonate authigenesis, possibly as rhodochrosite. Since ca. 1940, calcite and diatom varves have formed under eutrophic conditions, whereas Fe enrichment decreased and finally stopped due to fixation as pyrite in the shallow sites. Our results suggest that redox‐controlled geochemical focusing determines the distribution of Mn and Fe, as well as the occurrence of authigenic minerals such as vivianite and Mn‐carbonate.
Results of a multidisciplinary strategy to improve the management of cardiovascular risk factors after liver transplantation
Authors: Sastre Lydia , García Raquel , Viñals Clara , Amor Antonio J. , Yago Gema , Hervás Alicia , Sánchez Lorena , Trabal Joan , Molero Judit , Escudé Laia , Pagano Giulia , Blasco Miquel , Gilabert Rosa , Ruiz Pablo , Colmenero Jordi , Navasa Miquel , Ortega Emilio , Crespo Gonzalo 
Published: February 2022

Abstract
Although liver transplantation (LT) recipients are at high cardiovascular risk (CVR), the management of CVR factors (CVRF) after LT is far from optimal and needs to be improved. For this reason, we developed a multidisciplinary protocol to standardize the identification, risk stratification, management, and targets of therapy of CVRF during the first post‐LT year. The grade of identification and control of CVRF 12 months after LT in the postintervention cohort (LT January 2018–January 2020, n = 150) were compared with a control cohort who underwent LT between July 2015 and December 2016 (n = 100). Before LT, the prevalence of metabolic‐associated fatty liver disease as the indication of LT and the presence of obesity were significantly higher in the postintervention cohort, whereas the prevalence of other CVRF and renal dysfunction tended to be higher. Cyclosporine A was used less frequently in the postintervention cohort, whereas everolimus tended to increase. At 12 months after LT, the proportion of patients with measured blood pressure (88% vs. 56%), glycosilated hemoglobin (HbA1c; 96% vs. 72%), and high‐density lipoprotein/low‐density lipoprotein cholesterol (67% vs. 33%) was higher in the postintervention than in the control cohort (all p < 0.001). Blood pressure (64% vs. 36%, p = 0.02) and HbA1c (85% vs. 70%, p = 0.1) were within target in more individuals with hypertension and diabetes mellitus, respectively, in the postintervention cohort. Median total cholesterol levels were lower in the postintervention (184 mg/dl; interquartile range [IQR], 160–210 mg/dl) than in the control cohort (212 mg/dl; IQR, 186–240 mg/dl; p = 0.02). At 2 years after LT, the incidence of cardiovascular events was 14% in the control cohort and 6% in the postintervention cohort (p = 0.063). In conclusion, a multidisciplinary, multiprofessional strategy can achieve a higher grade of assessment and management of post‐LT CVR despite a worsening metabolic profile of LT recipients.
Analysis of inhibitory properties of Ce‐citrate as a green corrosion inhibitor of low alloy steel in neutral chloride solution
Authors: Marunkić Dunja , Jegdić Bore , Pejić Jovanka , Milošević Milena , Marinković Aleksandar , Radojković Bojana 
Published: February 2022

AbstractThe new environmentally friendly corrosion inhibitor Ce‐citrate was analyzed in 0.05 M NaCl solution on the AISI 4130 steel. For comparison, corrosion inhibitor Ce‐chloride is tested in the same concentration as Ce‐citrate (0.3 mM). Inhibitor efficiencies were determined by applying electrochemical impedance spectroscopy and potentiodynamic polarization measurements. The results of electrochemical measurements, the contact angle measurements, as well as the surface appearance of the specimens after the immersion in the inhibitive NaCl solution for 96 h confirmed that the new environmentally friendly inhibitor (Ce‐citrate) has a significantly higher protective ability than the Ce‐chloride. The protective ability of Ce‐citrate increases over time, according to the proposed mechanism of its action. In the inhibitive layer formed in NaCl solution containing Ce‐citrate, XPS analysis revealed the presence of cerium in oxidation states CeIII and CeIV, citrate anions (carboxyl O–C═O group as well as C–OH and C–C and C–H bonds), oxide, hydroxide, and oxyhydroxide of iron (mainly FeOOH and Fe2O3). The mechanism of inhibitory action of Ce‐citrate was proposed and analyzed in detail.