bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarkers of endothelial dysfunction and atherosclerosis in hidradenitis suppurativa
Authors: González‐López Marcos A. , Ocejo‐Viñals J. Gonzalo , López‐Sundh Ana E. , Guiral Sandra , Ruiz‐Solana Marta , Mata Cristina , Portilla Virginia , Corrales Alfonso , Blanco Ricardo , Hernández Jose L. 
Published: June 2022

AbstractHidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased prevalence of subclinical atherosclerosis and cardiovascular risk. Angiopoietin‐2 (Ang‐2), asymmetric dimethylarginine (ADMA), and osteoprotegerin (OPG) are molecules related to endothelial dysfunction (ED) and atherosclerosis, but also to disease severity in patients with chronic inflammatory disorders. In this case–control study, we aimed to investigate serum Ang‐2, ADMA, and OPG levels in patients with HS, and to assess the potential relationship between these levels and disease severity. Seventy‐five patients with HS and 60 controls were assessed. Serum Ang‐2, ADMA, and OPG concentrations were determined in all participants. HS patients had significantly higher Ang‐2 and ADMA levels than controls after adjusting for confounders. Besides, Ang‐2 concentrations positively correlated with disease severity in the adjusted multivariable analysis. Nevertheless, serum OPG levels did not significantly differ between HS patients and controls. Our results indicate that serum Ang‐2 and ADMA levels are significantly increased in patients with HS. Furthermore, Ang‐2 might be a suitable marker of HS severity.
Real estate investors and the U.S. housing recovery
Authors: Lambie‐Hanson Lauren , Li Wenli , Slonkosky Michael 
Published: June 2022

AbstractU.S. house prices fell nearly 30% between 2006 and 2012. Meanwhile, homeownership rates declined as mortgage credit supply tightened and investors bought up properties. Although nationally house prices recovered to prebust levels by 2016, homeownership rates declined through mid‐2016, as investors, particularly those purchasing through corporations, gained market share. By exploiting heterogeneity in zip codes' exposure to Fannie Mae and Freddie Mac programs that affected investors' access to foreclosed properties, we find that increased presence of investors explains a significant fraction of the house price recovery. Investors reduced vacancies and shortened the time foreclosed properties spent in bank ownership.
Phenolics in buckwheat hull extracts and their antioxidant activities on bulk oil and emulsions
Authors: Lee Haeseong , Lim Taehwan , Kim Jaecheol , Kim Ryun Hee , Hwang Keum Taek 
Published: June 2022

AbstractBuckwheat hulls are discarded as waste, although they have more phenolic compounds than buckwheat groats. The antioxidant activities of buckwheat hull extracts prepared with water, 50% ethanol, and 100% ethanol were investigated in bulk oil, oil‐in‐water (O/W), and water‐in‐oil (W/O) emulsions. The relationship between the phenolic compositions of the extracts and their antioxidant activities in the three different lipid systems was also evaluated. Fifty percent ethanol extract had the highest total phenolic content (327 mg gallic acid equivalent [GAE]/g extract) followed by water and 100% ethanol extracts (211 and 163 mg GAE/g extract, respectively). The total oxidation rate (k) was not significantly different among the bulk oils added with the buckwheat hull extracts. However, in the O/W emulsion, the k was more reduced by the 50% and 100% ethanol extracts than by the water extract at the concentration of 100 µg GAE/g (2.9, 2.8, and 3.7 Totox/day, respectively). The k of the W/O emulsion was more reduced by the 100% ethanol extract than by the water and 50% ethanol extract at the concentration of 100 µg GAE/g (3.8, 4.7, and 4.5 Totox/day, respectively). Multivariate statistical analysis revealed that the contents of phenolic acids and their derivatives were the highest in the water extract among the extracts, while the contents of flavonoid glycosides and methylated polyphenols were the highest in the 50% and 100% ethanol extracts, respectively. The results suggest that flavonoid glycosides and methylated polyphenols could be potential candidates for retarding the oxidation of the emulsion system.Practical ApplicationBuckwheat hull extracts could retard lipid oxidation. Flavonoid glycosides and methylated polyphenols in buckwheat hull extracts may have an antioxidative effect on lipids. Thus, buckwheat hulls could be used as an antioxidant in lipid systems, as flavonoid glycosides and methylated polyphenols are properly extracted from buckwheat hulls.
Validity and Reliability of the Turkish Version of the DASH‐TR Questionnaire in Rheumatoid Arthritis Patients, Based on Rasch Analysis
Authors: Basakci Calik Bilge , Demir Pervin , Gur Kabul Elif , Caglayan Berna Cagla , Keskin Aylin , Karasu Ugur 
Published: June 2022

AbstractAimThis study aimed to examine the validity and reliability of the Turkish version of the Disabilities of the Arm, Shoulder and Hand Problems (DASH‐TR) questionnaire in rheumatoid arthritis (RA) using the Rasch analysis.MethodA total 97 individuals (13 men, 84 women; mean age:51.99 ± 11.12 years, range: 20‐65 years) diagnosed as having RA according to the criteria of the American College of Rheumatology were included. The functional status of the upper extremities was evaluated with the DASH‐TR questionnaire, patient global health with a visual analog scale (VAS), disease activity with Disease Activity Score 28‐C‐reactive protein (DAS28‐CRP), and disability with Health Assessment Questionnaire (HAQ). DASH‐TR was applied to the patients with RA who did not receive any treatment for test‐retest at 1‐week intervals. DASH‐TR results were analyzed using the Rasch analysis.ResultsIn the sample of patients with RA, it was determined that the DASH‐TR scale did not provide a unidimensional structure and the items were collected in two dimensions. The first 20 items and the last nine items were differentiated in the two‐dimensional structure, and the factor load of m21 was low. Person separation index was obtained as 0.948. Internal consistency reliability was quite high. A significant positive correlation was found between the DASH‐TR and VAS, DAS28 and HAQ. There was excellent test‐retest reliability according to the intra‐class correlation coefficient (0.921, 95% CI 0.882‐0.947; P < 0.001).ConclusionThe DASH‐TR is a reliable and valid questionnaire and can be used for measurement of functional status of the upper extremities in RA.
Talimogene laherparepvec resulting in near‐complete response in a patient with treatment‐refractory Merkel cell carcinoma
Authors: Cilento Michael A. , Klein Oliver , Egan Elizabeth , Roberts‐Thomson Rachel 
Published: June 2022

AbstractMerkel cell carcinoma (MCC) is a rare and aggressive cutaneous tumour of neuroendocrine cell origin, which can grow rapidly and metastasise early. Localised disease is treated with surgery and radiotherapy. Disease that reaches a more advanced stage can be treated with a variety of different treatment modalities including surgery, radiotherapy, chemotherapy, radionuclide therapy, immunotherapy, and intralesional therapy. We report a case of a patient who had exhausted all local and systemic treatment options and who subsequently had an exceptional response to intralesional injection of Talimogene laherparepvec (TVEC).
Is jealousy justifiable?
Authors: Wesselinoff Catherine 
Published: June 2022

AbstractJealousy has been disparaged as psychologically debilitating and morally flawed since well before Shakespeare wrote Othello and is indeed represented—particularly well—as far back as in Homer's portrayal of gods and goddesses in The Iliad. According to some of these traditional views, often shared by philosophers, psychologists and the general public, jealousy is the sign, if not of an irredeemably corrupt mind, then at least of an excessively possessive and insecure character. But does jealousy always indicate some sort of flaw or failure? Is jealousy rerehensible in all contexts? In the present paper, I intend to suggest some modifications to the view that it is, by giving jealousy a more sympathetic and charitable hearing than it normally receives, and suggesting that jealousy might, in some cases, be justifiable.
Association between liver fibrosis and incident dementia in the UK Biobank study
Authors: Parikh Neal S. , Kamel Hooman , Zhang Cenai , Kumar Sonal , Rosenblatt Russell , Spincemaille Pascal , Gupta Ajay , Cohen David E. , de Leon Mony J. , Gottesman Rebecca F. , Iadecola Costantino 
Published: June 2022

AbstractBackground and purposeThere is growing recognition that chronic liver conditions influence brain health. The impact of liver fibrosis on dementia risk was unclear. We evaluated the association between liver fibrosis and incident dementia in a cohort study.MethodsWe performed a cohort analysis using data from the UK Biobank study, which prospectively enrolled adults starting in 2007, and continues to follow them. People with a Fibrosis‐4 (FIB‐4) liver fibrosis score >2.67 were categorized as at high risk of advanced fibrosis. The primary outcome was incident dementia, ascertained using a validated approach. We excluded participants with prevalent dementia at baseline. We used Cox proportional hazards models to evaluate the association between liver fibrosis and dementia while adjusting for potential confounders.ResultsAmong 455,226 participants included in this analysis, the mean age was 56.5 years and 54% were women. Approximately 2.17% (95% confidence interval [CI] 2.13%–2.22%) had liver fibrosis. The rate of dementia per 1000 person‐years was 1.76 (95% CI 1.50–2.07) in participants with liver fibrosis and 0.52 (95% CI 0.50–0.54) in those without. After adjusting for demographics, socioeconomic deprivation, educational attainment, metabolic syndrome, hypertension, diabetes, dyslipidemia, and tobacco and alcohol use, liver fibrosis was associated with an increased risk of dementia (hazard ratio 1.52, 95% CI 1.22–1.90). Results were robust to sensitivity analyses. Effect modification by sex, metabolic syndrome, and apolipoprotein E4 carrier status was not observed.ConclusionLiver fibrosis in middle age was associated with an increased risk of incident dementia, independent of shared risk factors. Liver fibrosis may be an underrecognized risk factor for dementia.
Electrospray application of guava seed oil for shelf life extension of guava fruit
Authors: Kapoor Swati , Gandhi Neeraj , Kaur Gurkirat , Khatkar Sunil Kumar , Bala Manju , Nikhanj Pooja , Mahajan BVC , Sharma Deepansh 
Published: June 2022

SummaryGuava seed oil (GSO) extracted from agro‐waste of the guava processing industry was used to prepare emulsion‐based edible coating. GSO ranging from 5% to 20% oil containing soy lecithin emulsifier was homogenised and ultrasonicated for preparation of stable emulsion. GSO majorly contained linoleic fatty acid and the mean particle size of GSO emulsions was in the range of 1.350–3.134 μm. Transmission electron microscopy showed uniform distribution of GSO particles in water, depicting the efficiency of soy lecithin as an effective emulsifier. Water‐based electrostatic spray gun was used as a spray mechanism, wherein the charged particles of GSO emulsion were sprayed onto fresh guava fruits. The electrospray coated and control fruits (without coating) were stored in lined corrugated fibreboard boxes at ambient conditions and analysed for physiological, physico‐chemical, colour and microbiological changes throughout the storage period. Guava fruits coated with 15% GSO showed the best results with respect to weight loss, firmness, spoilage and microbial load. Shelf‐life studies conclude that GSO‐coated fruits could be stored well till 10 days with better quality as compared to control fruits with only 6 days shelf life.
Destination unknown: Parents and healthcare professionals' perspectives on transition from paediatric to adult care in Down syndrome
Authors: Peters Vincent J. T. , Bok Levinus A. , de Beer Lieke , van Rooij Joyce J. M. , Meijboom Bert R. , Bunt Jan Erik H. 
Published: June 2022

AbstractBackgroundTransitioning from paediatric medical care to adult care is a challenging process for children, parents and healthcare professionals. The aim of this study was to explore the experiences, concerns and needs of parents of children with Down syndrome and of professionals regarding this transition.MethodA qualitative study was performed using semi‐structured interviews with 20 parents of children with Down syndrome and six healthcare professionals.ResultsWe showed that parents and professionals have concerns during each of the three distinct phases of transition (preparation, transfer and integration). Data disclose specific concerns regarding communication, continuity of care and rebuilding trust. We propose a framework for the transition to adult care.ConclusionsThe transition in medical care for children with Down syndrome should be flexible, patient‐centred and coordinated together with patients and parents. Only in ensuring continuity of care will individuals with Down syndrome not get lost in transition.
African primary healthcare as complex adaptive system
Authors: Moosa Shabir 
Published: June 2022

AbstractBureaucratic African governments need to trust their health workers and populations on the way to the Africa Agenda 2063. Small defined populations cared for by a team with an appropriate mix of healthcare workers (from public and private sectors) and delivered in a comprehensive, continuous, coordinated manner can be the complex adaptive system to deliver better PHC and health for all in Africa.
Variation in prescribing of opioids for emergency department encounters: A cohort study in the Military Health System
Authors: Larson Mary J. , Bauer Mark R. , Moresco Natalie , Huntington Nick , Ritter Grant , Paul‐Kagiri Rachelle , Hyppolite Regine , Richard Patrick 
Published: June 2022

AbstractRationale, Aims and ObjectivesEmergency department (ED) clinicians account for approximately 13% of all opioid prescriptions to opioid‐naïve patients and variability in the rates of prescribing have been noted among individual clinicians and different EDs. This study elucidates the amount of variability within a unified health system (the U.S. Military Health System [MHS]) with the expectation that understanding the sources of variability will enable health system leaders to improve the quality of decision making.MethodsThe design was a retrospective cohort study examining variation in opioid prescribing within EDs of the US MHS. Participants were Army soldiers who returned from a deployment and received care between October 2009 and September 2016. The exposure was ED encounters at a military treatment facility. Key measures were the proportion of ED encounters with an opioid prescription fill; total opioid dose of the fill (morphine milligram equivalent, MME); and total opioid days‐supply of the fill.ResultsThe mean proportion of ED encounters with an opioid fill across providers was 19.7% (SD 8.8%), median proportion was 18.6%, and the distribution was close to symmetric with the 75th percentile provider prescribing opioids in 24.6% of their ED encounters and the 25th percentile provider prescribing in 13.4% of their encounters. The provider‐level mean opioid dose per encounter was 113.1 MME (SD 56.0) with the 75th percentile (130.1) 50% higher than the 25th percentile (87.4). The mean opioid supply per encounter was 6.8 days (SD 3.9) with more than a twofold ratio between the 75th percentile (8.3) and the 25th (4.1). Using a series of multilevel regression models to examine opioid fills associated with ED encounters and their dose levels, the variation among providers within facilities was much larger in magnitude than the variation among facilities.ConclusionAmong ED encounters of Army soldiers at military treatment facilities, there was substantial variation among providers in prescribing opioid prescriptions that were not explained by patient case‐mix. These results suggest that programmes and protocols to address less than optimal prescribing in the ED should be initiated to improve the quality of care.
“I have a certain standard:” HBCU women's heterosexual aspirations and identity negotiation
Authors: Dunn Mercedez D. 
Published: June 2022

AbstractObjectiveThe present study expands scholarship on collegiate relationship formation by exploring heterosexual Black HBCU women's romantic aspirations for identity formation.BackgroundCollegiate environments structure sex and dating. However, extant research has not adequately considered how racialization matters for gendered relationship formation in these contexts and has yet to establish how racial, gender, and class identity formation and performance converge to structure Black college women's relational desires and opportunities.MethodThe study uses 30 in‐depth interviews with cisgender, heterosexual Black women at an HBCU to investigate their romantic and sexual experiences and expectations.ResultsHBCU women's romantic aspirations were organized by their race, gender, and aspirant class locations. They identified committed, monogamous, equitable relationships with similarly situated Black men as a relational ideal. Nonetheless, women expressed barriers to obtaining this relationship structure within their campus landscape and sought to otherwise negotiate romantic opportunities in accordance with respectable middle‐class Black feminine identities.ConclusionHBCU women's characterizations of ideal partnerships revealed the ways existing race, class, and gender structures are simultaneously accepted, reified, and problematized in Black women's identity negotiation through collegiate romance. Though HBCUs seem ideal for satisfactory sexual and romantic connections for Black middle‐class aspirant women, inequities on and off‐campus and rigid standards for respectability leave women with limited opportunities to obtain all they desire.
The effect of prescribing vitamin D analogues and serum vitamin D status on both contracting COVID‐19 and clinical outcomes in kidney dialysis patients'
Authors: Tangwonglert Theerasak , Davenport Andrew 
Published: June 2022

AbstractAimsVitamin D plays a role in innate immune system activation, and deficiency increases susceptibility to respiratory infections and disease severity including COVID‐19. We determined whether vitamin D levels and medications were associated with contracting COVID‐19, and disease severity defined by hospitalisation and dialysis patient mortality.MethodsWe reviewed serum vitamin D levels, and prescription of cholecalciferol and alfacalcidol along with corresponding medical records of adult dialysis patients from a United Kingdom tertiary centre between March 2020 and May 2021. COVID‐19 infection was determined by polymerase chain reaction (PCR) results.Results362 (35%) of 1035 dialysis patients tested PCR positive for COVID‐19. COVID‐19 positive patients had lower native median vitamin D (65 (39–95) versus 74 (40.5–101) nmol/L (p = .009) despite greater prescription of cholecalciferol (median 20 000 (20000‐20 000) versus 20 000 (0–20 000) IU/week), p < .001, but lower prescription of alfacalcidol 0 (0–3.0) versus 2.0 (0.–5.0) ug/week, p < .001. On multivariate logistic regression COVID‐19 infection was associated with haemodialysis versus peritoneal dialysis (p < .001), cholecalciferol dose (p < .001) and negatively with alfacalcidol (p < .001). However, serum vitamin D levels and alfacalcidol dosages were not significantly different for those requiring hospitalisation compared to those managed at home, although those who died were prescribed lower alfacalcidol dosages.ConclusionDialysis patients who contracted COVID‐19 had lower levels of native vitamin D prior to COVID‐19 and were prescribed lower dosages of alfacalcidol. However, there was no association between vitamin D status and disease severity. This retrospective observational analysis supports a potential role for vitamin D and susceptibility to COVID‐19 infection in dialysis patients.
Dental caries status in individuals with hearing difficulties: A systematic review and meta‐analysis
Authors: Bhadauria Upendra Singh , Purohit Bharathi , Agarwal Deepali , Priya Harsh 
Published: June 2022

AbstractAimsThe purpose of the systematic review and meta‐analysis was to assess the dental caries status in individuals with hearing difficulties.Methods and ResultsSearches were conducted in six databases with no restriction on publication date. The cross‐sectional and comparative cross sectional studies assessing the dental caries status of hearing impaired individuals using standardized evaluation criteria were included. PubMed, Web of Science, Cochrane, Wiley Online, Lilacs, and Scopus databases were searched to identify the relevant papers published before August 1, 2021. The risk of bias assessment was carried out by New Castle Ottawa Quality Assessment Scale. Three thousand three hundred thirty five potentially relevant references were identified in the systematic literature search. Thirteen relevant publications that fulfilled the eligibility criteria were included in the systematic review and the meta analysis. The overall analysis of the included studies revealed pooled dental caries prevalence of 58.0% (95% CI 0.41–0.74) among the hearing impaired individuals. The overall dental caries experience of the included studies showed a mean pooled DMFT of 2.68 (95% CI 1.24–4.12).ConclusionThe present systematic review and meta‐analysis reported high dental caries prevalence in hearing impaired individuals.
Understanding the experiences of plasma donors in Canada's new source plasma collection centres during COVID‐19: A qualitative study
Authors: Holloway Kelly 
Published: June 2022

AbstractBackground and ObjectivesTo address a national concern over the sufficiency of plasma, Canadian Blood Services (CBS) initiated a proof‐of‐concept programme with three new source plasma collection centres, aiming to demonstrate a cost‐effective template for future source plasma collection and to alleviate the concerns and risks associated with the dependence on the United States. This study uses social capital as a framework to assess the success of the proof‐of‐concept collection centres.Materials and MethodsOne‐hundred and one qualitative interviews with source plasma donors in three new source plasma centres in Canada were carried out.ResultsCBS played a critical role in motivating whole‐blood donors to switch to plasma donation by building on their identity as a donor and facilitating access. Community was central to ensuring that donors returned. The importance of the social network was apparent through relationships participants developed with staff and through the relationships that staff had with each other. Donors wanted to understand more about the uses of plasma so that they could promote donation through their social networks outside the centre.ConclusionCampaigns to convert existing blood donors to plasma donors should build on their identity as a donor and structure the centre as a safe and welcoming place. To retain donors, blood collection agencies should emphasize community by facilitating staff ability to work well together and connect with the donor. Blood operators have the potential to expand existing social networks and foster trust through the dissemination of knowledge about plasma more broadly in more diverse communities.