bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Creation of a Multidomain Neighborhood Environmental Vulnerability Index Across an Urban Center
Authors: Uong Stephen P. , Zhou Jiayi , Lovinsky-Desir Stephanie , Albrecht Sandra S. , Azan Alexander , Chambers Earle C. , Sheffield Perry E. , Thompson Azure , Wilson Joseph , Baidal Jennifer Woo , Stingone Jeanette A. 
Published: December 2022

ABSTRACTCompared to previous studies that have typically used a single summary score, we aimed to construct a multidomain neighborhood environmental vulnerability index (NEVI) to characterize the magnitude and variability of area-level factors with the potential to modify the health effects of environmental pollutants. Using the Toxicological Prioritization Index framework and data from the 2015-2019 U.S. Census American Community Survey and the 2020 CDC PLACES Project, we quantified census tract-level vulnerability overall and in 4 primary domains (demographic, economic, residential, and health status), 24 subdomains, and 54 distinct area-level features for New York City (NYC). Overall and domain-specific indices were calculated by summing standardized feature values within the subdomains and then aggregating and weighting subdomains within equally-weighted primary domains. In citywide comparisons, NEVI was correlated with both the Neighborhood Deprivation Index (r = 0.91) and the Social Vulnerability Index (r = 0.87) but provided additional information on features contributing to vulnerability. Vulnerability varied spatially across NYC, and hierarchical cluster analysis using subdomain scores revealed six patterns of vulnerability across domains: 1) low in all, 2) primarily low except residential, 3) medium in all, 4) high demographic, economic, and residential 5) high economic, residential, and health status, and 6) high demographic, economic and health status. Created using a tool that offers flexibility for theory-based construction, NEVI provided detailed metrics of vulnerability across domains that can inform targeted research and public health interventions aimed at reducing the health impacts from environmental exposures across an urban center.
Long-term safety and efficacy of treating symptomatic, partial-thickness rotator cuff tears with fresh, uncultured, unmodified, autologous, adipose-derived regenerative cells isolated at the point of care: 41 months follow-up of a prospective, randomized, controlled, first-in-human clinical trial
Authors: Lundeen Mark , Hurd Jason L. , Hayes Matthew , Hayes Meredith , Facile Tiffany R. , Furia John P. , Maffulli Nicola , Alt Christopher , Alt Eckhard U. , Schmitz Christoph , Pearce David A. 
Published: December 2022

AbstractBackgroundSymptomatic, partial-thickness rotator cuff tears (sPTRCT) are problematic. Management of sPTRCT with fresh, uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) isolated from lipoaspirate at the point of care is safe and leads to improved shoulder function without adverse effects. This study tested the hypothesis that management of sPTRCT with injection of UA-ADRCs is safe and more effective than injection of corticosteroid even in the long run.MethodsSubjects who had completed a former randomized controlled trial were enrolled in the present study. At baseline these subjects had not responded to physical therapy treatments for at least six weeks, and were randomly assigned to receive either a single injection of an average 11.4 × 106 UA-ADRCs (n = 11) or a single injection of 80 mg of methylprednisolone (n = 5). Safety was assessed by rigorously documenting and evaluating treatment emergent adverse events. As per protocol efficacy was assessed using the ASES Total score, RAND Short Form-36 Health Survey (SF-36) Total score and VAS pain score at 24 weeks (W24) and W52 post-treatment as well as at 33.2 ± 1.0 (mean ± standard deviation) months (M33) and 40.6 ± 1.9 months (M41) post-treatment. Magnetic resonance imaging (MRI) of the index shoulder was performed at baseline, W24, W52, M33 and M41 post-treatment.ResultsThere were no greater risks connected with injection of UA-ADRCs than those connected with injection of corticosteroid. Injection of UA-ADRCs resulted in significantly higher mean ASES Total scores at W24, W52 and M41, a significantly higher mean SF-36 Total score at W24, and significantly higher mean VAS Pain scores at W24 and W52 post-treatment than injection of corticosteroid (p<0.05). Treatment outcome could not be assessed using measurements of tear volume on MRI scans. On the other hand, MRI scans at W24 post-treatment allowed to “watch the UA-ADRCs at work”. There was no relationship between treatment outcome and baseline data, including those data characterizing UA-ADRCs that can be collected with a clinical test.ConclusionsThe present study further supports management of sPTRCT with injection of UA-ADRCs.Trial registrationClinicaltrials.govNCT04077190(September 4, 2019).
Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy
Authors: Khan Archie A. , Langston Harry C. , Walsh Louis , Roscoe Rebecca , Jayawardhana Shiromani , Francisco Amanda F. , Taylor Martin C. , McCann Conor J. , Kelly John M. , Lewis Michael D. 
Published: December 2022

AbstractDigestive Chagas disease (DCD) is an enteric neuropathy caused byTrypanosoma cruziinfection. There is a lack of evidence on the mechanism of pathogenesis and rationales for treatment. We used a mouse model that recapitulates key clinical manifestations to study how infection dynamics shape DCD pathology, and the impact of treatment with the front-line drug benznidazole. Curative treatment at 6 weeks post-infection resulted in sustained recovery of GI transit function, whereas sub-curative treatment led to infection relapse and gradual return of DCD symptoms. Neuro-immune gene expression profiles shifted from chronic inflammation to a tissue repair signature after cure, accompanied by increased glial cell activity and regenerative neurogenesis in the myenteric neuronal plexus. Delaying treatment until 24 weeks post-infection led to a partial reversal of the DCD phenotype, suggesting the accumulation of permanent tissue damage over the course of chronic infection. Our study shows that murine DCD pathogenesis is sustained by chronicT. cruziinfection and is not an inevitable consequence of acute stage denervation. The risk that irreversible enteric neuromuscular tissue damage and dysfunction will develop highlights the importance of prompt diagnosis and treatment. Finally, these findings support the concept of treating asymptomaticT. cruziinfected individuals with benznidazole to prevent DCD development.
Studies on the co-metabolism of glucose and glycerol in the fungusUmbelopsis isabellina
Authors: Dritsas Panagiotis , Aggelis George 
Published: December 2022

AbstractOver the past few years it is observed an increased interest for oleaginous microorganisms in the perspective to produce microbial oils of great commercial interest through the consumption of low/zero cost substrates. In this paper, the physiology of the fungusUmbelopsis isabellinagrowing on blends of glycerol and glucose was investigated. In all experiments the fungus completely consumed glucose and produced satisfactory quantities of biomass containing reserve lipids in high percentages. However, glycerol concentration in the growth medium was negatively correlated to glucose assimilation rate, mainly during the balanced-growth phase. Nevertheless, at high initial concentrations, glycerol was partially consumed and seemed to contribute positively to the suppression of lipid degradation. Following the discovery of this complex regulatory mechanism regarding glucose and glycerol co-assimilation, the activity of three key-enzymes namely aldolase, glycerol kinase and glycerol dehydrogenase, which are implicated in glycerol and glucose assimilation, was investigated. The experiments revealed a clear preference of the fungus for glucose over glycerol. On the other hand, storage polysaccharides are degraded instead of storage lipid at the late oleaginous phase for maintenance purpose. These new biochemical features will enable the design of appropriate growth media for the co-fermentation of these two substrates byU. isabellinawith the aim to maximize lipid accumulation.
Repetition accelerates neural markers of memory consolidation
Authors: Yu Wangjing , Zadbood Asieh , Chanales Avi J. H. , Davachi Lila 
Published: December 2022

AbstractNo sooner is an experience over than its neural memory representation begins to be strengthened and transformed through the process of memory replay. Using fMRI, we examined how memory strength manipulated through repetition during encoding modulates post-encoding replay in humans. Results revealed that repetition did not increase replay frequency in the hippocampus. However, replay in cortical regions and hippocampal-cortical coordinated replay were significantly enhanced for repeated events, suggesting that repetition accelerates the consolidation process. Interestingly, we found that replay frequency in both hippocampus and cortex modulated behavioral success on an immediate associative recognition test for the weakly encoded information, indicating a significant role for post-encoding replay in rescuing once-presented events. Together, our findings highlight the relationships of replay to stabilizing weak memories and accelerating cortical consolidation for strong memories.
Combinatorial circuit dynamics orchestrate flexible motor patterns inDrosophila
Authors: Shiozaki Hiroshi M. , Wang Kaiyu , Lillvis Joshua L. , Xu Min , Dickson Barry J. , Stern David L. 
Published: December 2022

SummaryMotor systems flexibly implement diverse motor programs to pattern behavioral sequences, yet their neural underpinnings remain unclear. Here, we investigated the neural circuit mechanisms of flexible courtship behavior inDrosophila. Courting males alternately produce two types of courtship song. By recording calcium signals in the ventral nerve cord (VNC) in behaving flies, we found that different songs are produced by activating overlapping neural populations with distinct motor functions in a combinatorial manner. Recordings from the brain suggest that song is driven by two descending pathways – one defines when to sing and the other specifies what song to sing. Connectomic analysis reveals that these “when” and “what” descending pathways provide structured input to VNC neurons with different motor functions. These results suggest that dynamic changes in the activation patterns of descending pathways drive different combinations of motor modules, thereby flexibly switching between different motor actions.
Mathematical modelling of brain mTOR activity identifies selective vulnerability of cell types and signalling pathways
Authors: Pokhilko Alexandra , Sleven Hannah , Cader M. Zameel 
Published: December 2022

AbstractThe mTOR pathway is a global regulator of protein biosynthesis and cellular homeostasis. Understanding the differences in mTOR pathway activity between cell types is important for elucidating the role of mTOR in physiological and pathophysiological processes. The non-linear structure of the pathway, with multiple feedback loops and inputs complicates the interpretation of experimental data and requires mathematical modelling. We modelled mTOR activation under healthy and disease conditions using recently published single nuclei gene expression data from the human brain. The model predicts substantial variations in mTOR pathway activity between cell types, with neurons and astrocytes being highly sensitive to insulin and neuregulins, while vascular smooth muscle cells and pericytes are highly sensitive to PDGF. Two principal negative regulators of mTOR - TSC and PTEN have prominent roles in PDGF-mediated mTOR activation in endothelial cells and oligodendrocytes. In Alzheimer’s Disease brain we find that insulin-mediated activitation of mTOR pathway is selectively upregulated in microglia and oligodendrocytes and downregulated in other cells. Our mathematical modelling characterises ligand sensitivity of cerebrovascular cell types and provides insights into the brain mTOR dynamics in health and disease.
Moresa: confronting risks in a highly uncertain environment
Authors: Perez Perez Juan Ernesto 
Published: December 2022

Learning outcomes
At the end of the case students will be able to:
1. Relate risk as one of the 12 principles in project management contemplated in the international standards of the PMBOK Seventh Edition guide.
2. Determine high-level risks by articulating the WBS and RBS of a construction project.
3. Perform a qualitative and quantitative analysis of the probability and impact of risks through the heat map tool and the Expected Monetary Value (EMV) technique.
4. Propose the different response strategies contemplated in the risk management through the formulation of a response and contingency plan.

Case overview/synopsis
MORESA S.A.S was a family company founded in 1994, whose value proposition focused on construction and permanent advice for the execution of innovative and contemporary projects with more than 27 years of experience in the city of San José de Cucuta, department of Norte de Santander, Colombia. The objective of the case is to Relate risk as one of the 12 principles in project management contemplated in the international standards of the PMBOK Seventh Edition guide; Determine high-level risks by articulating the WBS and RBS of a construction project; Perform a qualitative and quantitative analysis of the probability and impact of risks through the heat map tool and the Expected Monetary Value (EMV) technique and propose the different response strategies contemplated in the risk management through the formulation of a response and contingency plan. The teaching case is designed for academic programs in areas of knowledge of civil engineering, architecture and at postgraduate level such as: Master’s in civil engineering, Master’s in risk management, Master in project management or MBA. For this case, an expert judgment was developed with professionals belonging to different areas of knowledge. Likewise, secondary information was collected from the organization's strategic documents and the analogous estimation through the historical records of the project portfolio developed by the construction company. Finally, the case, classified in the Built Environment, a challenge that project managers must face in VUCA environment through risk management.

Complexity academic level
The teaching case is designed for academic programs in areas of knowledge of civil engineering, architecture and at postgraduate level such as: Master’s in civil engineering, Master’s in risk management, Master’s in project management or MBA. In the modules of risk management, project management, international standards, the case guides the applicability of methods and artifacts used in risk management considering the process identification, quantitative, qualitative analysis, and development of response strategies and contingency plans.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 2: Built Environment.
Antecedents and intervention mechanisms of institutional distrust of P2P accommodations during COVID-19 in China
Authors: Fu Shixuan , Yang Jingjing , Su Linlin 
Published: December 2022

Purpose
COVID-19 affects the peer-to-peer (P2P) accommodation industry. With regard to prospect theory, individuals’ negative emotions, such as institutional distrust, are easily evoked and impede consumption intention in an environment of permeating uncertainty and risks. While existing research indicates the negative effects of institutional distrust, scant research has explored its antecedents and intervention mechanisms. This study thus aims to unveil the influencing factors and explore mitigating mechanisms of customers’ institutional distrust of P2P accommodations.

Design/methodology/approach
Online reviews data were used to identify the underlying critical issues. The authors developed a model to depict how institutional distrust is formed under the boundary condition of subjective norm by the results. The model was verified using a questionnaire survey. Finally, in-depth semi-structured interviews were conducted to ensure its robustness.

Findings
The external environment and internal platform effectiveness are two critical aspects affecting institutional distrust of P2P accommodations. The external environment influences institutional distrust through perceived threat, explaining the formation mechanism of customers’ institutional distrust through customers’ internal psychology. Furthermore, the authors found subjective norm moderating the effect of perceived threat on customers’ institutional distrust.

Research limitations/implications
This is one of the first studies, to the best of the authors’ knowledge, to explore institutional distrust of P2P accommodations after COVID-19. The finding contributes to studies on P2P accommodation by uncovering the contingent role of subjective norm in influencing customers’ institutional distrust.

Originality/value
This is a pioneering study that explores the antecedents and mitigating mechanisms of institutional distrust of P2P accommodations during the new normal of COVID-19.
A systematic inquiry of energy management in smart grid by using SAP-LAP and IRP approach
Authors: Pal Chandra , Shankar Ravi 
Published: December 2022

Purpose
The need to address energy management as a significant innovation in the smart grid is emphasized to enable a more effective penetration of renewable energy to achieve energy savings and CO2 emission reductions. The purpose of this study is to propose a holistic, flexible decision framework for energy management in a smart grid.

Design/methodology/approach
According to the situation actor process−learning action performance (SAP−LAP) model, the variables have been identified after a comprehensive analysis of the literature and consideration of the opinions of domain experts. However, the importance of each SAP−LAP variable is not the same in real practice. Hence, focus on these variables should be given based on their importance, and to measure this importance, an interpretive ranking process based ranking method is used in this study. This helps to allocate proportionate resource to each SAP−LAP variable to make a better decision for the energy management of the smart grid.

Findings
This study ranked five actors based on their priorities for energy management in a smart grid: top management, generator and retailor, consumers, government policy and regulation and technology vendors. Furthermore, actions are also prioritized with respect to performance.

Practical implications
The SAP−LAP model conveys information about the state of energy management in India to actors who may proceed or manage the flow of electricity. Additionally, this study aids in detecting vulnerabilities in the current energy generation, transmission and distribution technique. The synthesis of SAP results in LAP, which assists in recommending improvement actions learned from the current situation, actors and processes.

Originality/value
The SAP−LAP model is a revolutionary approach for examining the current state of energy management in a unified framework that can guide decision-making in conflicting situations, significantly the contradictory nature of India’s renewable energy and power sectors.
Macro environment determinants affecting the availability of artemisinin-based combination therapies in Uganda
Authors: Oluka Nagitta Pross , Mkansi Marcia 
Published: December 2022

Purpose
Artemisinin-based combination therapies (ACTs) have been developed to treat uncomplicated malaria. However, scanty studies exist to inform the role of macro factors in explaining the nonavailability of ACT in developing countries. Therefore, this paper aims to evaluate the different macro-environment factors affecting the availability of ACTs in the public hospital setting.

Design/methodology/approach
This study applied a quantitative methodological approach and structural equation modeling (SEM) to test hypotheses statistically. SEM examines linear causal relationships among variables while accounting for measurement error. Confirmatory factor analysis (CFA) was used to assess model reliability. CFA and SEM were used to determine the shared variance-covariance of variables, define the latent construct and provide a more precise way to account for the error variances associated with the variables, which, if untested, could lead to biased parameter estimates. This was guided by the data collected from 40 general public hospitals with 283 respondents.

Findings
This study’s results support a model for promoting social-cultural, technological and legal factors. The availability of ACTs is significantly affected by legal factors. Improving legal aspects by a unit can enhance ACT availability by 0.59. Political factors scored the least, and they do not influence the availability of malaria drugs.

Research limitations/implications
The design was quantitative and cross-sectional. Future research could be longitudinal with a mixed-method approach and consider other external stakeholders.

Practical implications
Reducing the impact of the nonavailability of antimalarial drugs in general public hospitals requires a holistic concerted and coordinated supply chain approach that tackles the political, economic, social-cultural norms, technological and legal factors.

Originality/value
The authors develop and test a model using macro factors: political, economic, social, cultural, technological and legal factors. This model is relevant for many developing countries to supply chain coordination perpetually experiencing medicine shortages.
Comparison of dimples and grooves based on friction and leakage properties of textured mechanical seals
Authors: Wang Xiuying , Chen Yu , Ding Kai , Yu Chengtao 
Published: December 2022

Purpose
This study aims to obtain a design scheme of the surface texture on mechanical seal with lower friction and leakage by comparing two common texture types: dimples and grooves.

Design/methodology/approach
An optimal free-form shape and an optimal circular shape were chosen by multi-objective optimization, and two types of grooves with different directions were chosen by a series of experiments. Then, the optimal free-form dimple, the optimal circular dimple, the groove perpendicular to the direction of movement (hereafter called groove-1) and the groove angled at 60° to the direction of movement (hereafter called groove-2) were compared by experiments under different loads.

Findings
The optimal free-form dimple shows a better performance in terms of a lower coefficient of friction (COF) and a lower leakage than the other shapes, especially for the high speed and low load conditions. The reduction rate of COF is up to 37.5%, and the leakage rate is reduced by about 12.5%. The dimples have a lower leakage than the grooves. The groove angled at 60° to the direction of movement is easier to pump the oil into the interface of the sealing face, leading to a lower friction but a higher leakage.

Originality/value
This study provides a feasible surface texture design scheme for improving the combination performance of mechanical seals.