bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE DESIGN OF INFORMATION SYSTEMS FILING OUTPATIENT MEDICAL RECORDS
Authors: Astuti Dewi Listiawati , Gunawan Hafsah Ghina Ghaida , Sari Irda , Kurniawati Rina , Yuniarty Neneng 
Published: August 2022

Abstract: The system information section filing in UPT Puskesmas Rahayu to submit a medical record file to any of the poly, assembling medical records, store medical records, retention medical records are already inactive. This research aims to design and create a system of information filing outpatient medical records in UPT Puskesmas Rahayu in terms of borrowing and return the medical record file as well as facilitate the retention of medical records with the use of qualitative methods. The Data used in the study in UPT Puskesmas Rahayu, namely interviews, observation, and FGD (Focus Group Discussion). This study shows the input data of the patients is in accordance with UPT Puskesmas Rahayu. Input patient data include No RM, the Name of the KK, the Patient's Name, Gender, Address, and Villages. This research resulted in the information system of medical record filing outpatient procedures that can facilitate the officer in the management of the filing of medical records. Keywords: borrowing and return; medical record filing; puskesmas Abstrak: Sistem informasi bagian filing di UPT Puskesmas Rahayu untuk mengirimkan berkas rekam medis ke setiap poli, assembling rekam medis, menyimpan rekam medis, meretensi rekam medis yang sudah in aktif. Penelitian ini bertujuan untuk merancang dan membuat sistem informasi filing rekam medis rawat jalan di UPT Puskesmas Rahayu dalam hal peminjaman dan pengembalian berkas rekam medis serta mempermudah dalam retensi rekam medis dengan menggunakan metode kualitatif. Data yang digunakan dalam penelitian di UPT Puskesmas Rahayu yaitu wawancara, observasi dan FGD (Focus Group Discussion). Penelitian ini menunjukkan input data pasien sudah sesuai dengan yang ada di UPT Puskesmas Rahayu. Input data pasien meliputi No RM, Nama KK, Nama Pasien, Jenis Kelamin, Alamat, dan Kelurahan. Penelitian ini menghasilkan sistem informasi rekam medis filing rawat jalan yang dapat mempermudah petugas dalam pengelolaan filing rekam medis. Kata kunci: peminjaman dan pengembalian; puskesmas; rekam medis filing
THE DESIGN OF A STOCK TAKING INVENTORY APPLICATION BASED ON ANDROID
Authors: Haerani Reni , Desianasari Pegie 
Published: August 2022

Abstract. The stocktaking activities at the company take a relatively long time depending on the number of goods and assets owned. As a result, the company can only carry out stock taking at the end of the day or in a non-peak season. This condition resulted in the company’s being disorganized in doing stocktaking. This study aims to create an application that can facilitate the management of stocktaking inventory of goods. The system development method uses the SDLC (System Development Life Cycle) model. Which has the stages of planning, system analysis, system design, system implementation, system testing and system maintenance. Application improvement starts from system preparation to detailed system design terms, including database design, input output design, and Android-based technology. The information system is built using Android Studio using the Java programming language. This study resulted in a stock-taking application for inventory that stores information about stock taking inventory by displaying features of stock ownership data, inventory items, updating item data, and stocktaking inventory reports. It is hoped that PT. Barata Indonesia (Persero)Turbine Component Division will quickly, effectively, and efficiently in data processing stocktaking inventory of existing goods and compiling reports per period systematically. Keywords: Android; Inventory; Stocktaking Abstrak- Aktivitas stock opname dalam perusahaan memakan waktu yang relatif lama bergantung menurut banyaknya barang dan aset yang dimiliki, sebagai akibatnya perusahaan hanya bisa melaksanakan stock opname waktu akhir atau dalam keadaan tidak ramai (non-peak season). Kondisi ini mengakibatkan perusahaan tidak tertib dalam mengerjakan stock opname. Penelitian ini bertujuan menciptakan aplikasi yang bisa memudahkan manajemen stock opname persediaan barang. Metode pengembangan sistem menggunakan model SDLC (System Development Life Cyle) dimana mempunyai tahapan-tahapan Perencanaan, Analisis Sistem, Perancangan Sistem, Implementasi Sistem, Pengujian sistem dan Perawatan sistem. Perbaikan aplikasi dimulai dari persiapan sistem sampai termin desain sistem yang rinci, meliputi rancangan database, input output, sampai teknologi berbasis android. Sistem informasi dibangun menggunakan android studio menggunakan bahasa pemrograman java. Penelitian ini menghasilkan sebuah aplikasi stock opname persediaan barang yang menaruh informasi tentang stock opname persediaan barang dengan menampilkan fitur data stock opname, persediaan barang, update data barang dan report stock opname persediaan barang. Diharapkan bisa dipakai pihak PT. Barata Indonesia (Persero) Divisi Komponen Turbin secara cepat, efektif dan efisien pada pengolahan data stock opname persediaan barang yang terdapat dan menyusun laporan per periode secara sistematis.Kata Kunci : Android; Persediaan Barang; Stock Opname
APPLICATION OF TOPSIS METHOD FOR DETERMINATION OF ENGLISH COURSE INSTITUTION
Authors: Sukamto Sukamto , Nugroho Riki Ario , Kharesma Bayu 
Published: August 2022

Abstract: English course institutions are one of the most sought after non-formal education places to learn and improve English language skills, especially to be able to master the TOEFL well. To choose a suitable course institution, that is by visiting the respective course places. Of course, things like this take a lot of time, effort, and money. For this reason, a decision support system is needed that can provide recommendations for the best course institutions using the TOPSIS method. The data used are 18 alternatives with criteria including course fees, number of facilities, length of study hours, instructor's TOEFL, and distance from the course. The calculation results provide a recommendation that the alternative A Class IBT is the best English course institution. Keywords: English Course; Decision Support System; TOPSIS Abstrak:. Lembaga kursus bahasa inggris merupakan salah satu tempat pendidikan nonformal yang saat ini banyak dicari untuk mempelajari dan meningkatkan kemampuan bahasa inggris khususnya untuk dapat menguasai TOEFL dengan baik. Untuk memilih lembaga kursus yang cocok yaitu dengan mendatangi ke tempat kursus masing-masing. Tentunya hal seperti ini banyak waktu, tenaga, dan biaya yang diperlukan. Untuk itu diperlukan suatu sistem pendukung keputusan yang dapat memberikan rekomendasi lembaga kursus yang terbaik menggunakan metode TOPSIS. Data yang digunakan adalah 18 alternatif dengan kriteria antara lain uang kursus, jumlah fasilitas, lama jam belajar, TOEFL instruktur, dan jarak tempat kursus. Hasil perhitungan memberikan rekomendasi bahwa alternatif A Class IBT merupakan lembaga kursus bahasa Inggris yang terbaik. Kata kunci: Kursus Bahasa Inggris; Sistem Pendukung Keputusan; TOPSIS
Development of Conceptual Ideas of Ethnopedagogy in Kyrgyzstan During the Years of Independence
Authors: Kenzheshev K. 
Published: August 2022

The article discusses issues related to the development of conceptual ideas of ethno-pedagogical education in the Kyrgyz Republic in the first years of independence. In particular, a set of external and internal factors that had a direct impact on the development of ideas, principles, techniques, methods, forms and means of folk pedagogy is described. Namely, certain trends in the development of ethnopedagogical education in the context of ideological chaos, social cataclysms and economic upheavals in the initial period of independence are analyzed. The factors that determine the dominance of foreign methods, techniques and forms of education and the lag of the domestic education system, in which the presence of basic means, ideas and principles of ethnopedagogy is now gradually decreasing, are also considered. All these factors undoubtedly affect the upbringing of the younger generations. Moreover, it is no exaggeration to say that in the modern conditions of globalization, the threat of the disappearance of many languages, original cultures, and, consequently, ethnic groups are sharply increasing, and in the context of such processes, ethnopedagogy acquires special importance and relevance.
Рассматриваются вопросы касающиеся развития концептуальных идей этнопедагогического образования в Киргизской Республике в первые годы независимости. Описана совокупность внешних и внутренних факторов, оказывавших непосредственное влияние на развитие идей, принципов, приемов, методов, форм и средств народной педагогики. Проанализированы определенные тенденции развития этнопедагогического образования в контексте идеологического хаоса, социальных катаклизмов и экономических потрясений в начальный период независимости. Рассмотрены факторы, обуславливающие доминирование зарубежных методов, приемов и форм обучения и отставание отечественной системы образования, присутствие в которой основных средств, идей и принципов этнопедагогики в настоящее время постепенно уменьшается. Все эти факторы, вне всякого сомнения, сказываются на процесс воспитания подрастающего поколения. В современных условиях глобализации резко возрастает угроза исчезновения многих языков, самобытных культур, а также этносов и в контексте таких процессов этнопедагогика приобретает особое значение и актуальность.
Aerobic exercise-induced circulating extracellular vesicle combined decellularized dermal matrix hydrogel facilitates diabetic wound healing by promoting angiogenesis
Authors: Liu Haifeng , Wu Bing , Shi Xin , Cao Yanpeng , Zhao Xin , Liang Daqiang , Qin Qihuang , Liang Xinzhi , Lu Wei , Wang Daping , Liu Jun 
Published: August 2022

Background: Insufficient blood supply results in unsatisfactory wound healing, especially for challenging wound repair such as diabetic wound defects. Regular exercise training brings a lot of benefits to cardiovascular fitness and metabolic health including attenuation of T2DM progression. Circulating extracellular vesicles (EVs) are postulated to carry a variety of signals involved in tissue crosstalk by their modified cargoes, representing novel mechanisms for the effects of exercise. Prominently, both acute and chronic aerobic exercise training can promote the release of exercise-induced cytokines and enhance the angiogenic function of circulating angiogenic cell–derived EVs.Methods: We investigated the possible angiogenesis potential of aerobic exercise-induced circulating EVs (EXE-EVs) on diabetic wound healing. Circulating EVs were isolated from the plasma of rats subjected to 4 weeks of moderate aerobic exercise or sedentariness 24 h after the last training session. The therapeutic effect of circulating EVs was evaluated in vitro by proliferation, migration, and tube formation assays of human umbilical vein endothelial cells (HUVECs), as well as in vivo by quantification of angiogenesis and cutaneous wound healing in diabetic rats.Results: The number of circulating EVs did not change significantly in exercised rats 24 h post-exercise in comparison with the sedentary rats. Nevertheless, EXE-EVs showed remarkable pro-angiogenic effect by augmenting proliferation, migration, and tube formation of HUVECs. Furthermore, the findings of animal experiments revealed that the EXE-EVs delivered by decellularized dermal matrix hydrogel (DDMH) could significantly promote the repair of skin defects through stimulating the regeneration of vascularized skin.Discussion: The present study is the first attempt to demonstrate that aerobic exercise-induced circulating EVs could be utilized as a cell-free therapy to activate angiogenesis and promote diabetic wound healing. Our findings suggest that EXE-EVs may stand for a potential strategy for diabetic soft tissue wound repair.
Effects of decellularized extracellular matrix derived from Jagged1-treated human dental pulp stem cells on biological responses of stem cells isolated from apical papilla
Authors: Phothichailert Suphalak , Nowwarote Nunthawan , Fournier Benjamin P.J. , Trachoo Vorapat , Roytrakul Sittiruk , Namangkalakul Worachat , Osathanon Thanaphum 
Published: August 2022

Objective: Indirect Jagged1 immobilization efficiently activates canonical Notch signaling in human dental pulp stem cells (hDPSCs). This study aimed to investigate the characteristics of the Jagged1-treated hDPSC-derived decellularized extracellular matrix (dECM) and its biological activity on odonto/osteogenic differentiation of stem cells isolated from apical papilla (SCAPs).Methods: Bioinformatic database of Jagged1-treated hDPSCs was analyzed using NetworkAnalyst. hDPSCs seeded on the Jagged1 immobilized surface were maintained with normal or osteogenic induction medium (OM) followed by decellularization procedure, dECM-N, or dECM-OM, respectively. SCAPs were reseeded on each dECM with either the normal medium or the OM. Cell viability was determined by MTT assay. Characteristics of dECMs and SCAPs were evaluated by SEM, EDX, immunofluorescent staining, and alcian blue staining. Mineralization was assessed by alizarin red S, Von Kossa, and alkaline phosphatase staining. Statistical significance was considered at p &lt; 0.05.Results: RNA-seq database revealed upregulation of several genes involved in ECM organization, ECM–receptor interaction, and focal adhesion in Jagged1-treated hDPSCs. Immobilized Jagged1 increased the osteogenesis of the hDPSC culture with OM. dECMs showed fibrillar-like network structure and maintained major ECM proteins, fibronectin, type I-collagen, and glycosaminoglycans. A decrease in calcium and phosphate components was observed in dECMs after the decellularized process. Cell viability on dECMs did not alter by 7 days. Cell attachment and f-actin cytoskeletal organization of SCAPs proliferated on Jagged1-treated dECMs were comparable to those of the control dECMs. SCAPs exhibited significantly higher mineralization on dECM-N in OM and markedly enhanced on dECM-OM with normal medium or OM conditions.Conclusion: Jagged1-treated hDPSC-derived dECMs are biocompatible and increase odonto/osteogenic differentiation of SCAPs. The results suggested the potential of Jagged1 dECMs, which could be further developed into ECM scaffolds for application in regenerative medicine.
Inactivated vaccine injection and immunoglobulin G levels related to severe coronavirus disease 2019 (Delta) pneumonia in Xi’an, China: A single-centered, retrospective, observational study
Authors: Yang Han , Ma Jinbao , Li Aifang , Lei Jing , Shang Fenqing , Cheng Yue , Han Bei , Li Hongbo , Chen Yuee , Yang Yuanli , Xu You 
Published: August 2022

The World Health Organization declared a public health emergency of international concern in January 2020. The Delta variant became the main epidemic strain on 11 May 2021. Vaccines were proven highly effective in controlling hospitalization and deaths associated with severe acute respiratory syndrome coronavirus 2 infections. Real data on vaccine efficacy against B.1.617.2 infection in the Chinese population were currently limited. This study aimed to evaluate the protective effect of inactivated vaccine injection and immunoglobulin (Ig) G levels in coronavirus disease 2019 (COVID-19) severity. This retrospective study included patients with COVID-19 in Xi’an Chest Hospital from December 2021 to January 2022. The protective effect of inactivated vaccine injection and IgG levels on COVID-19 severity was analyzed using multiple logistic regressions. A total of 580 patients were included in the study, of whom 158 (27.24%) were mild, 412 (71.03%) were moderate, 5 (0.9%) were severe, and 5 (0.86%) were critical. Severe case (including severe and critical) rates were 1.72% (10/580). Compared with the unvaccinated group, the vac+IgG− group had a 0.21 (0.02–2.05)-fold risk of suffering from severe cases, and the vac+IgG+ group had a 0.05 (0–0.63)-fold risk of suffering from severe cases. Of the 10 severe cases, 8 were older than 60 years, 8 were men, 8 had underlying diseases, 6 were in the unvaccinated group, and 2 were in the vac+IgG− group. Vaccination and sufficient IgG antibody production can protect patients with COVID-19 from severe cases. Booster vaccine injection can produce a stronger immune response and protection.
Clinical features and outcomes of patients with stable or unstable chest pain and no-obstructive coronary artery disease
Authors: Cambise Nello , Telesca Alessandro , Tremamunno Saverio , Felici Tamara , De Vita Antonio , Filice Monica , Ingrasciotta Gessica , Ruscio Eleonora , Crea Filippo , Lanza Gaetano A. 
Published: August 2022

BackgroundCoronary microvascular dysfunction can be responsible for both stable angina and acute coronary syndrome (ACS). There are scarce data, however, about comparisons of clinical characteristics and outcomes of these 2 groups of patients.Materials and methodsWe studied 47 consecutive patients who underwent coronary angiography for angina syndromes and showed no obstructive stenosis. Patients were divided in 2 groups, according to their clinical presentation, i.e., stable angina (n = 21) or non-ST segment elevation ACS (NSTE-ACS; n = 26). An intracoronary acetylcholine (Ach) test was performed in 12 and 17 patients of the 2 groups, respectively. Angina status, assessed by Seattle Angina Questionnaire (SAQ), and clinical events were assessed after 1, 6, and 30 months. An exercise stress test was performed 1 month after discharge.ResultsClinical characteristics and exercise test results of the 2 groups were largely similar. Ach testing induced epicardial or microvascular spasm in 6 (50.0%) and 10 (58.8%) stable and NSTE-ACS patients, respectively (p = 0.72). Stable patients reported higher rates of angina, compared to NSTE-ACS patients, both at 1 (p = 0.04) and 30 months (81 vs. 50%, p = 0.036) of follow-up. SAQ scores were also lower in stable vs. NSTE-ACS patients. Ach testing results showed no association with clinical outcomes.ConclusionClinical characteristics and exercise and Ach testing results are similar in angina patients with no-obstructive coronary artery disease with a stable or NSTE-ACS presentation. Stable patients show a worse symptomatic outcome irrespective of Ach test results.
Comparison of mid-term clinical outcome in heart transplantation patients using mycophenolate mofetil vs. enteric-coated mycophenolate sodium
Authors: Jeon Kina , Kim Darae , Choi Jin-Oh , Cho Yang Hyun , Sung Kiick , Oh Jaewon , Cho Hyun Jai , Jung Sung-Ho , Lee Hae-Young , Park Jin Joo , Choi Dong-Ju , Kang Seok-Min , Kim Jae-Joong , Jeon Eun-Seok 
Published: August 2022

BackgroundMycophenolate mofetil (MMF) is a prodrug of mycophenolic acid (MPA) and a key immunosuppressant for improving graft survival in patients with heart transplantation (HTx). However, dose reduction or interruption is occasionally needed due to gastrointestinal (GI) side effects. Enteric-coated mycophenolate sodium (EC-MPS) is an alternative form of MPA delivery to improve GI tolerability. In the present study, the efficacy of EC-MPS compared with MMF in HTx patients was investigated.MethodsIn this retrospective study, the Korean Organ Transplant Registry (KOTRY) data were used to analyze the efficacy and rejection rate of MMF and EC-MPS. A total of 611 patients was enrolled from 2014 to February of 2021. Patients were divided based on the use of MMF or EC-MPS at 6 months post-HTx. Patients who were not prescribed MMF or EC-MPS were excluded. Graft survival, all-cause mortality, and treated rejection were compared between the two groups. All statistical analyses were performed using SPSS; characteristics were compared using Pearson chi-square test and survival rate with Kaplan-Meier plot and log-rank test.ResultsA total of 510 HTx patients was analyzed (mean age: 51.74 ± 13.16 years, males: 68.2%). At 6 months after HTx, 78 patients were taking EC-MPA (12.8%) and 432 patients were taking MMF (70.7%). The median follow-up was 42.0 months (IQR: 21.7–61.0 months). Post-HTx outcomes including overall survival, all cause mortality, acute cell mediated rejection (ACR), acute antibody mediated rejection (AMR), treated rejection, and cardiac allograft vasculopathy (CAV) were comparable between the two groups during follow-up.ConclusionNotable differences were not observed in overall survival, all cause mortality, ACR, AMR, treated rejection, and CAV between MMF and EC-MPS groups. Efficacy of EC-MPS was similar to that of MMF in HTx patients during mid-term follow up after HTx.
Evaluation of T-Shaped Fins With a Novel Layout for Improved Melting in a Triple-Tube Heat Storage System
Authors: Ebrahimnataj Tiji Mohammadreza , Mohammed Hayder I. , Ibrahem Raed Khalid , Dulaimi Anmar , Mahdi Jasim M. , Sh. Majdi Hasan , Keshtkar Mohammad Mehdi , Talebizadehsardari Pouyan 
Published: August 2022

The effects of T-shaped fins on the improvement of phase change materials (PCM) melting are numerically investigated in vertical triple-tube storage containment. The PCM is held in the middle pipe of a triple-pipe heat exchanger while the heat transfer fluid flows through the internal and external pipes. The dimension effects of the T-shaped fins on the melting process of the PCM are investigated to determine the optimum case. Results indicate that while using T-shaped fins improves the melting performance of the PCM, the improvement potential is mainly governed by the fin’s body rather than the head. Hence, the proposed T-shaped fin did not noticeably improve melting at the bottom of the PCM domain; additionally, a flat fin is added to the optimal case (Added-Fin case) and compared to the No-Fin, Uniform-Fin, and Optimum T-shaped Fin cases (no added fin). The analysis shows that the total heat storage rate of the Added-Fin case increased by 141.7%, 58.8%, and 47.6% compared with the No-Fin, Uniform-Fin, and the Optimum T-shaped Fin cases, respectively. Furthermore, the total melting time for the Added-Fin case was 1882 s and decreased by 59.6%, 38.4%, and 33.6% compared with those of the No-Fin, Uniform-Fin, and the Optimum T-shaped Fin (Optimum) cases, respectively.
Early-Life Exposure of Pigs to Topsoil Alters miRNA and mRNA Expression in Peripheral Blood Mononuclear Cells
Authors: De Souza M. M. , Koltes D. A. , Beiki H. , Sales M. A. , Tsai T. , Maxwell C. V. , Zhao J. , Koltes J. E. 
Published: August 2022

Exposure to less-hygienic conditions during early childhood has been associated with stimulation and development of the immune system. A recent study indicated that exposure of piglets to soil-borne microbes during lactation was related with modulation of gut microbiota and immune function. To identify the potential molecular mechanisms and pathways impacted by early-life topsoil exposure, we analyzed the messenger RNA (mRNA) and micro-RNA (miRNA) expression in peripheral blood mononuclear cells (PBMCs) from these piglets. Total RNA was extracted from the PBMCs of piglets exposed to topsoil only from d 4–d 21 of life (mRNA n = 6; miRNA n = 5) or unexposed control pigs (mRNA n = 6; miRNA n = 8) at 11, 20, and 56 days of age. Small RNA and mRNA were sequenced with 50-bp single-end reads using Illumina chemistry. Sequence data were quality checked with FASTQC software and aligned to the Sscrofa 11.1 genome with the STAR aligner for mRNA and mirDeep2 for miRNA. Differential expression (DE) analysis was performed using PROC Glimmix of SAS to evaluate changes in expression due to topsoil exposure over time with genes declared DE at a false discovery rate (FDR) of q &lt; 0.10. A total of 138 mRNA and 21 miRNAs were identified as DE for the treatment by age interaction. Ontology enrichment analysis of DE mRNA revealed Gene ontology (GO) terms directly involved in the connection between T-cell and antigen-presenting cells that are associated with T-cell activation. Key regulatory genes identified include PTPRJ, ITGB3, TRBV30, CD3D, mir-143, mir-29, and mir-148a. While these results require validation, this study provides data supporting the hypothesis that less-hygienic environments during early life may contribute to the development of the immune system.