bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Chinese Materia Medica Informed Nineteenth-Century British Pharmaceutical Knowledge: The Case of Daniel Hanbury’s Reception and Translation of Bencao Literature
Authors: An Sooyoung 
Published: March 2022

Summary
Focusing on the figure of Daniel Hanbury and his research on the subject of Chinese materia medica, this essay sheds light on the reception of Chinese bencao knowledge by British naturalists in the context of the development of pharmaceutical knowledge during the mid-nineteenth century. While Hanbury and his collaborators extensively consulted diverse Chinese texts, most noticeably the Bencao gangmu, they relegated to history much Chinese bencao and medical knowledge. Hanbury’s collection of local knowledge through collaboration with Sinologists, as well as his process of selecting, omitting and editing highlights the complex roles that Chinese knowledge played in the formation of nineteenth-century British pharmaceutical knowledge—not just in terms of new Chinese materia medica and Hanbury’s own empirical research but also as a foil against which he helped formulate what constituted a new body of scientific pharmaceutical knowledge.
Cephalic salt gland evolution in Mesozoic pelagic crocodylomorphs
Authors: Cowgill Thomas , Young Fls Mark T , Schwab Julia A , Walsh Stig , Witmer Lawrence M , Herrera Yanina , Dollman Kathleen N , Turner Alan H , Brusatte Stephen L 
Published: March 2022

Abstract
Secondarily marine tetrapod lineages have independently evolved osmoregulatory adaptations for life in salt water but inferring physiological changes in extinct marine tetrapods is difficult. The Mesozoic crocodylomorph clade Thalattosuchia is unique in having both direct evidence from natural endocasts and several proposed osteological correlates for salt exocrine glands. Here, we investigate salt gland evolution in thalattosuchians by creating endocranial reconstructions from CT scans of eight taxa (one basal thalattosuchian, one teleosauroid, two basal metriorhynchoids and four metriorhynchids) and four outgroups (three extant crocodylians and the basal crocodyliform Protosuchus) to identify salt gland osteological correlates. All metriorhynchoids show dorsolateral nasal cavity expansions corresponding to the location of nasal salt glands in natural casts, but smaller expansions in teleosauroids correspond more with the cartilaginous nasal capsule. The different sizes of these expansions suggest the following evolutionary sequence: (1) plesiomorphically small glands present in semi-aquatic teleosauroids draining through the nasal vestibule; (2) moderately sized glands in the basalmost metriorhynchoid Pelagosaurus; and (3) hypertrophied glands in the clade comprising Eoneustes and metriorhynchids, with a pre-orbital fenestra providing a novel exit for salt drainage. The large gland size inferred from basal metriorhynchoids indicates advanced osmoregulation occurred while metriorhynchoids were semi-aquatic. This pattern does not precisely fit into current models of physiological evolution in marine tetrapods and suggests a unique sequence of changes as thalattosuchians transitioned from land to sea.
Assessing the Impact of Prenatal Medication for Opioid Use Disorder on Discharge Home With Parents Among Infants With Neonatal Opioid Withdrawal Syndrome
Authors: Singleton Rosalyn , Rutz Sara , Day Gretchen , Hammes Melissa , Wilson Amy Swango , Herrick Mary , Mazut Connie , Brunner Laura , Prince Jennifer , Desnoyers Christine , Shaw Jennifer , Hirschfeld Matthew , Palis Heather , Slaunwhite Amanda 
Published: March 2022

Objectives
The number of women with opioid-related diagnoses in the United States has significantly increased in recent decades, resulting in concomitantly higher rates of infants born with neonatal opioid withdrawal syndrome (NOWS). Addressing prenatal opioid exposure is a priority for Alaska health systems. The objectives of this study were to: (1) identify maternal and neonatal factors associated with receipt of Medication for opioid use disorder (MOUD) and (2) determine the impact of prenatal MOUD on discharge to parents among infants with NOWS in 3 Alaska hospitals.

Methods
A retrospective chart review using a standard abstraction form was conducted to collect data on neonatal and maternal characteristics, neonatal treatment, and infant discharge disposition for infants with NOWS born at the 3 hospitals between July 2016 and December 2019. A multivariable logistic regression model was used to determine factors associated with discharge to parents.

Results
There were 10,719 births at the 3 hospitals during the study period, including 193 infants (1.8%) with NOWS. Among the 193 mothers, 91 (47.2%) received MOUD during pregnancy. Among infants with NOWS, 136 (70.5%) were discharged to parents, 51 (26.4%) were discharged to a relative or foster care. Infants were significantly (odds ratio 3.9) more likely to be discharged to parents if the mother had received prenatal MOUD.

Conclusions
MOUD among pregnant women with opioid use disorder furthers the goal of keeping families together and is a critical step towards reducing the impact of the ongoing opioid epidemic on Alaska families, communities, and the child welfare system.
Increasing Mortality in Venovenous Extracorporeal Membrane Oxygenation for COVID-19–Associated Acute Respiratory Distress Syndrome
Authors: Braaten Jacob A. , Bergman Zachary R. , Wothe Jillian K. , Lofrano Arianna E. , Matzek Luke J. , Doucette Melissa , Saavedra-Romero Ramiro , Bohman John K. , Prekker Matthew E. , Lusczek Elizabeth R. , Brunsvold Melissa E. 
Published: March 2022

OBJECTIVES:
Determine the factors associated with mortality in venovenous extracorporeal membrane oxygenation (V-V ECMO) patients with COVID-19 infection and provide an updated report of clinical outcomes for patients treated with V-V ECMO for COVID-19 in Minnesota.

DESIGN:
Multicenter prospective observational study.

SETTING:
The four adult Extracorporeal Life Support Organization–certified Centers of Excellence in Minnesota.

PATIENTS:
A total of 100 patients treated with V-V ECMO for COVID-19–associated acute respiratory distress syndrome (ARDS) from March 2020 to May 2021.

INTERVENTIONS:
Not applicable.

MEASUREMENTS AND MAIN RESULTS:
The primary outcome was 60-day survival for patients treated with V-V ECMO for COVID-19. Outcomes of patients treated from November 2020 to May 2021(cohort 2) were compared with data from a previous cohort of patients, collected from March 2020 to October 2020 (cohort 1). The data from both cohorts were merged into a single dataset (Combined Cohort). Survival on V-V ECMO due to COVID-19–associated ARDS significantly decreased after October 2020 (63% vs 41%; p = 0.026). The median interval from hospital admission to V-V ECMO cannulation was significantly associated with 60-day mortality (10 d [6–14 d] in nonsurvivors vs 7 d [4–9 d] in survivors; p = 0.001) in the Combined Cohort and was also significantly longer in cohort 2 than cohort 1 (10 d [7–14 d] vs 6 d [4–10 d]; p < 0.001). In the Combined Cohort, the 60-day survival for patients who did not receive steroids was 86% (n = 12) versus 45% (n = 39) for patients who received at least one dose of steroids (p = 0.005).

CONCLUSIONS:
There was a significant increase in mortality for patients treated with V-V ECMO for COVID-19–associated ARDS in cohort 2 compared with cohort 1. Further research is required to determine the cause of the worsening trend in mortality.
Eight-year trajectories of malalignment progression in symptomatic knee osteoarthritis
Authors: Li Mingyang , Nie Yong , Zeng Yi , Wu Yuangang , Wu Limin , Liu Yuan , Shen Bin 
Published: March 2022

Abstract

Background:
Although various therapies have been developed to treat malalignment in osteoarthritic knees, the pattern of malalignment progression is still unclear. This study aimed to identify homogeneous subgroups with distinct trajectories of malalignment progression in subjects with symptomatic knee osteoarthritis (KOA) and to determine corresponding risk factors.

Methods:
Eight-year follow-up (from 2004 to 2012) data on 1252 participants with symptomatic KOA from the Osteoarthritis Initiative were included. Varus/valgus angle progression was characterized by group-based trajectory models. Time-varying covariates were introduced into the model to investigate how they affected trajectories. Multinomial logistic regression for trajectory group membership was applied to ascertain risk factors.

Results:
Five subgroups were identified. Participants in the varus worsening trajectory (n = 166) or valgus worsening trajectory (n = 118) proceeded to worsen malalignment over time. The neutral trajectory (n = 378), varus stable trajectory (n = 328), and valgus stable trajectory (n = 262) maintained close to the initial varus/valgus angle over 8 years. Higher baseline Kellgren and Lawrence grade (odds ratio [OR] = 4.35, P
< 0.001 for varus; OR = 3.85, P
< 0.001 for valgus) and “severe” baseline malalignment (OR = 13.57, P < 0.001 for varus; OR = 23.04, P < 0.001 for valgus) were risk factors for worsening trajectories. The cutoff point of the baseline varus/valgus angle to discriminate between stable or worsening trajectory was −4.5° for varus and 3.6° for valgus.

Conclusions:
This study identified the malalignment progression pattern — minor malalignment (−4.5° to +3.6°) tends to remain stable, while major baseline malalignment is likely to progress. This provides a reference for therapy to prevent malalignment from deteriorating and emphasizes the necessity of determining the trigger factors for malalignment onset.
Mesenteric misadventure: An unusual suprapubic catheter complication
Authors: Pham Cecile T. , Lau Patrick , Hew Jonathan , Apostolou Christos , Chung Amanda 
Published: March 2022

Abstract
Although suprapubic cystotomy for catheter insertion is commonly performed, complications can be associated with serious morbidity. This case describes delayed recognition of a transperitoneal suprapubic catheter (SPC) traversing the small bowel mesentery and causing a closed loop obstruction of the caecum 7 years after SPC insertion. There are very few cases in the literature of SPC causing mesenteric perforation and to the best of our knowledge, this is the first reported case causing subsequent obstruction of the caecum and the longest delay of 7 years between SPC insertion and manifestation of bowel obstruction.
Safety and Efficacy of Oral Benzodiazepines for Periprocedural Anxiolysis: A Systematic Review
Authors: Boettler Michelle A. , Shahwan Kathryn T. , Cusick Austin , Avila Christina , Carr David R. 
Published: March 2022

BACKGROUND
Oral benzodiazepines (BZDs) are useful tools for periprocedural anxiolysis. The United States Food and Drug Administration (FDA) recently issued a black-box warning of their risks of abuse and dependence. We performed a systematic review evaluating the safety and efficacy of oral BZDs for periprocedural anxiolysis in outpatient dermatologic, plastic surgery, dental, and ophthalmologic procedures performed under local anesthesia.

METHODS
A systematic review of 5 databases was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Oral benzodiazepine safety and efficacy data were extracted from eligible articles.

RESULTS
A total of 43 articles and 4,060 subjects were included. Oral BZDs consistently imparted a positive anxiolytic effect and demonstrated superior or equivalent scores in patient satisfaction, surgeon satisfaction, pain, and anxiety to comparator groups in most studies. Thirty-five subjects experienced transient hypoxia, and 2 experienced transient hypertension. A total of 195 mild, self-limited adverse effects were reported. None of the studies addressed the risks of abuse and dependence in this clinical setting.

CONCLUSION
Short-term use of oral BZDs for periprocedural anxiolysis seems to be safe and effective. The 2020 FDA black-box warning should not deter their appropriate use in dermatologic surgery and other low-risk outpatient procedures.
Performance of the Modified Rapid Emergency Medicine Score in Patients With and Without Traumatic Brain Injury
Authors: Barbosa Genesis de Souza , Gaspar Juliane de Oliveira , Nogueira Lilia de Souza , Vieira Rita de Cássia Almeida , Lima Kézia Porto , Sousa Regina Márcia Cardoso de 
Published: March 2022

ABSTRACT

BACKGROUND: The modified Rapid Emergency Medicine Score (mREMS) is a recently published index to estimate the severity of trauma patients; however, little is known about its performance in patients with different types of trauma. This study verified the predictive capacity of mREMS in-hospital mortality in patients of blunt and penetrating trauma with and without traumatic brain injury (TBI) and the performance of this index compared with the Rapid Emergency Medicine Score, Injury Severity Score, New Injury Severity Score, and Trauma and Injury Severity Score. METHODS: This is a retrospective, correlational study that analyzed trauma patients 18 years or older, who attended at a hospital in Rio de Janeiro, Brazil. The receiver operating characteristic (ROC) curve was applied in the analyses. RESULTS: The sample consisted of 987 patients, 359 (36.4%) with TBI (225 blunt and 134 penetrating trauma). Regarding mREMS, the area under the ROC curve for TBI patients for in-hospital mortality was 0.506 (95% confidence interval [CI], 0.404-0.609) for penetrating injuries and 0.486 (95% CI, 0.402-0.571) for blunt injuries; the values in patients without TBI were 0.629 (95% CI, 0.554-0.703) and 0.618 (95% CI, 0.552-0.684), respectively. In relation to the other indices the mREMS presented the lowest area under the curve/ROC for penetrating and blunt TBI, and the Rapid Emergency Medicine Score for extracranial injuries. CONCLUSION: The mREMS showed no prognostic capacity for patients with TBI, and it presented the worst performance in relation to the Injury Severity Score, New Injury Severity Score, and Trauma and Injury Severity Score to discriminate cases of in-hospital mortality when considering trauma patients with and without TBI.
Evaluating the impact of personalized rehabilitation nursing intervention on postoperative recovery of respiratory function among thoracic surgery patients
Authors: Liu Ai , Li Mian , Gao Wenjin , Wen Xiaoke , Zhu Hui , Chen Yanyan 
Published: March 2022

Abstract

Background:
Owing to clinical developments and economic strain, perioperative care has undergone considerable changes. Therefore, it is important to review and critique the efficacy of existing practices in a context that is placing increasing emphasis on better efficacy and cost-containment. Considering that the objective involves devising approaches to minimize postoperative complications and reduce medical care, efforts should concentrate on postsurgical pulmonary complications that are common. The present analysis aims to examine how customized rehabilitation nursing intercession impacts the postsurgical restoration of respiratory functions in thoracic surgery patients.

Methods:
Prespecified search strategies will be employed to perform a methodological search of 6 databases namely EMBASE, Cochrane Library, PubMed, Web of Science, WanFang Database, and China National Knowledge Infrastructure. The analysis will comprise original publications that evaluated how personalized rehabilitation nursing intervention impacts postsurgical restoration of respiratory function in those who have undergone thoracic surgery. All considered publications are before December 25, 2021. Different authors will conduct an independent study selection process to evaluate the quality of the publications and extract required data. Based on the standardized mean difference and its 95% confidence interval, we estimate the summary effects for each meta-analyses. Based on heterogeneity in considered articles, the related data will be pooled through either a random- or fixed-effect meta-analysis. Lastly, the overall quality of evidence using appropriate methods will be performed.

Results:
The results of this analysis will systematically evaluate how customized rehabilitation nursing interference impact postsurgical healing of respiratory functions in patients who have undergone thoracic surgery by collecting the existing evidence.

Ethics and dissemination:
Not required.

Open Science Framework registration number:
10.17605/OSF.IO/NBVYW.
Clinical observation of Long chiropractic treatment on patients with neurogenic cervical spondylosis
Authors: Wang Chen , Gu Zhongping , Yu Junwu , Zhang Peizhen , Yang Faming 
Published: March 2022

Abstract
Neurogenic cervical spondylosis is the most common type of cervical spondylosis, accounting for approximately 60% percent of the incidence of cervical spondylosis. Cervical spine Long manipulation and sling exercise training (SET) have obtained good therapeutic results in clinical rehabilitation. The aim of this study was to evaluate the effect of Long manipulation combined with SET on neurogenic cervical spondylosis. In this assessor-blind, randomized controlled trial, 90 eligible patients will be randomized into a combination treatment group (Long manipulation combined with SET), a Long manipulation group and a conventional massage group. The visual analogue score, the Neck Disability Index score, and muscle fatigue in the bilateral upper oblique and Musculus sternocleidomastoideus, using mean power frequency and median frequency from the surface electromyography frequency domain index, will be assessed before and after the intervention at 0 and 4 weeks, respectively.

Trial registration: Registered in the Chinese Clinical Trial Registration Center with the number ChiCTR2100054978. Registered December 30, 2021.
Efficacy and safety of Qinghua Zhixie Decoction against diarrhea-predominate irritable bowel syndrome
Authors: Ji Lijiang , Zhao Xiaoying , Zhang Yuyan , Zhao Ping , Gong Rui , Li Fang , Huang Hua 
Published: March 2022

Abstract

Background:
Diarrhea-predominant irritable bowel syndrome (D-IBS) is the main subtypes of irritable bowel syndrome (IBS). In recent years, more than half of IBS patients have received complementary and alternative medicine. Traditional Chinese herbal formula is widely used in Asia, and clinical studies have also found that Chinese herbal formula could significantly improve abdominal pain and diarrhea. We plan to carry out a randomized, controlled, double blind, clinical studies to observe the clinical efficacy of Qinghua Zhixie decoction in the treatment of D-IBS.

Methods:
Four hundred sixty-four participants will be randomly assigned to the treatment group and control group. Patients in both groups would take medications and stimulations simultaneously. The outcomes of IBS symptom severity score, quality of life, psychological states, and recurrence rate will be recorded. Statistics will be analyzed with the SPSS 22.0.

Conclusions:
The findings of the study will identify the safety and efficacy of Qinghua Zhixie decoction in the treatment of D-IBS.

Trial registration: OSF Registration number:
DOI 10.17605/OSF.IO/C8MHW.
Postoperative thyroid crisis in an 11-year old male with McCune-Albright syndrome and atypical triiodothyronine hyperthyroidism
Authors: Hu Jingen , Hu Caibao 
Published: March 2022

Abstract

Rationale:
McCune-Albright syndrome (MAS) is a rare heterogeneous clinical disease caused by sporadic, somatic, and postzygotic mutations. Thyroid crisis is even rare in patients with MAS, and we report the clinical outcomes of the first case of a MAS patient with atypical triiodothyronine (T3) hyperthyroidism who developed thyroid crisis after orthopedic surgery.

Patient concerns:
The patient with MAS and atypical T3 hyperthyroidism was an 11-year-old man who had undergone surgery for a right femur fracture and shepherd bending deformity. His main symptoms were dizziness, nausea, and vomiting with elevated body temperature because of developed thyroid crisis. Thyroid function tests showed high T3 and remarkably high free T3 levels, and remarkably increased thyrotropin level, but unchanged thyroxine and free thyroxine levels.

Diagnosis:
The patient was diagnosed with postoperative thyroid crisis following surgery for a right femur fracture, shepherd bending deformity, and MAS with atypical T3 hyperthyroidism.

Interventions:
Propranolol was intravenously administered. The therapy included intravenous hydrocortisone, a saturated solution of potassium iodine and propylthiouracil, and continuous physical cooling.

Outcomes:
The patient was discharged after achieving a stable condition with normal thyroid and liver function after surgery because of active anti-thyroid crisis treatment.

Lessons:
The operation of such patients should focus on the pre-operative heart rate, platelet level, and thyroid hormone levels. Abnormal values should be adjusted to the normal range, and such patients should achieve complete hemostasis and transfuse with blood following surgery anemia.
Effects of the non-pharmacological interventions of traditional Chinese medicine on postpartum depression
Authors: Huang XiaoMei , Luo Shu , Wang Hongwei 
Published: March 2022

AbstractBackground:Postpartum depression (PPD) has become one of the common disorders during the postpartum period. The non-pharmacological interventions of traditional Chinese medicine (TCM) have achieved good results in the treatment of PPD. However, the efficacy of different non-pharmacological interventions of TCM for PPD has not been fully elucidated. Due to the large number of non-pharmacological intervention of TCM modalities, the selection of appropriate non-pharmacological interventions of TCM has become an urgent clinical problem. The aim of this network meta-analysis was to explore the best choice for different non-pharmacological interventions of TCM for PPD.Methods:PubMed, Web of Science, Scopus, Cochrane Library, Embase, China Scientific Journal Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wanfang Data were searched to identify the randomized controlled trials of non-pharmacological interventions of TCM for PPD from the inception to February 2022. Two researchers will be independently responsible for literature screening, data extraction, and assessment of their quality. Standard pair-wise and Bayesian network meta-analysis will be performed to compare the efficacy of different non-pharmacological interventions of TCM for PPD via Stata 14.0 and WinBUGS1.4 software.Results:The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.Conclusions:The conclusion of this systematic review will provide evidence for the selection of an optimal non-pharmacological interventions of TCM for PPD.Ethics and dissemination:Ethical approval is not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms.OSF REGISTRATION NUMBER:DOI 10.17605/OSF.IO/TM96G.