bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptación transcultural y validación de contenido de un cuestionario para explorar las perspectivas de fisioterapeutas de Argentina con respecto al uso de factores contextuales en el dolor musculoesquelético
Authors: Andreu Mauro Federico , Policastro Pablo , Terrasa Sergio Adrián , Rossettini Giacomo , Testa Marco , Dias de Carvalho Tatiana , Pardo Yolanda 
Published: November 2022

Objetivo: Describir los procesos de adaptación transcultural al español argentino y validación de contenido de la versión italiana de un cuestionario para explorar los conocimientos, creencias y actitudes de los fisioterapeutas de Argentina con respecto al uso de factores contextuales en el dolor musculoesquelético.
Materiales y método: El diseño de este estudio es un modelo mixto que incluye métodos cualitativos y cuantitativos dividido en tres etapas: adaptación transcultural, validez de contenido y prueba piloto. Para la validez de contenido, se aplicó el método Delphi modificado de dos rondas y se calcularon el índice de validez de contenido (IVC), la razón de validez de contenido (RVC) y el índice kappa modificado. Se realizó una prueba piloto para determinar la factibilidad y validez de contenido de la versión final.
Resultados: Este estudio incluyó 30 fisioterapeutas. Luego de aplicar los lineamientos recomendados para la traducción y adaptación transcultural, la nueva versión conservó las principales dimensiones de la versión original. La evaluación de la validez de contenido, realizada por un panel de expertos y mediante entrevistas cognitivas, determinó que los ítems incluidos en la versión resultante eran claros, relevantes y suficientes para el contexto argentino. De acuerdo con los resultados del análisis cuantitativo de la validez de contenido, las estimaciones del IVC, RVC y kappa alcanzaron valores iguales a 1,0.
Conclusión: Utilizando un enfoque sistemático e iterativo, se obtuvo la adaptación transcultural y validez de contenido del cuestionario en términos de claridad, relevancia y suficiencia, lo que permite evaluar a futuro sus propiedades psicométricas.
Plantas medicinais e fitoterápicos na atenção primária à saúde: contribuição para profissionais prescritores
Authors: Alice Beleza Macedo Jussara 
Published: November 2022

A fitoterapia é amplamente difundida no Brasil, tanto sua utilização de modo empírico e tradicional, como com base científica. A Atenção Primária à Saúde é a porta de entrada do sistema de saúde e é o nível de assistência que permite maior interação com os usuários e entre os profissionais. A Organização Mundial de Saúde e o Ministério da Saúde incentivam ações relacionadas com as práticas integrativas, principalmente a fitoterapia, tendo em vista o cenário mundial em relação a utilização de plantas medicinais e fitoterápicos, este estudo objetivou, realizar uma revisão bibliográfica integrativa com a finalidade de elencar informações que possam auxiliar os profissionais da atenção básica na prática de trabalho com a fitoterapia. Observou-se neste levantamento que o principal gargalo para o desenvolvimento da fitoterapia no Sistema Único de Saúde é a falta de conhecimento dos profissionais, em contra ponto a este, verificou-se abertura dos profissionais e usuários para utilização da fitoterapia como terapia farmacológica. Outro ponto importante que este estudo permitiu observar foi a existência de legislação norteadora de ações voltadas para a fitoterapia e a possibilidade de atuação da equipe multiprofissional da Atenção Básica na prescrição e orientação sobre o uso das plantas medicinais e fitoterápicos.
Handling Complexity in Modern Software Engineering: Editorial Introduction to Issue 32 of CSIMQ
Authors: Zimmermann Alfred , Marcinkowski Bartosz 
Published: November 2022

The potential of the Internet and related digital technologies, such as the Internet of Things (IoT), cognition and artificial intelligence, data analytics, services computing, cloud computing, mobile systems, collaboration networks, and cyber-physical systems, are both strategic drivers and enablers of modern digital platforms with fast-evolving ecosystems of intelligent services for digital products. This issue of CSIMQ presents three recent articles on modern software engineering. First, we focus on continuous software development and place it in the context of software architectures and digital transformation. The first contribution is followed by the description of the basis of specific security requirements and adequate digital monitoring mechanisms. Finally, we present a practical example of the digital management of livestock farming.
Imagined and extended contact experiences and adolescent bystanders' behavioral intentions in homophobic bullying episodes
Authors: António Raquel , Guerra Rita , Cameron Lindsey , Moleiro Carla 
Published: November 2022

AbstractBystanders' helping interventions in bias‐based bullying are rare, although they have the potential to intervene on behalf of the victim and quickly stop the aggression. Two studies tested, experimentally, the impact of adolescents' imagined (Study 1, N = 113, Mage = 16.17) and extended contact experiences (Study 2, N = 174, Mage = 15.79) on assertive bystanders' behavioral intentions in the context of homophobic bullying, an under‐researched but highly detrimental behavior that emerges mainly during early adolescence. Potential mediators (empathic concern, social contagion concerns, and masculinity/femininity threat) were also examined. Results showed that female younger participants revealed more behavioral intentions to help victims of homophobic bullying when asked to imagine an interaction with an outgroup member (Study 1). Younger participants revealed less masculinity/femininity threat in the positive extended contact condition, and female participants revealed less empathic concern in the negative extended contact condition (Study 2). Overall, these findings identify specific conditions (e.g., younger females) where indirect contact interventions (i.e., extended and imagined) are likely to have a stronger impact. Age and sex differences were found to illustrate how adolescents vary in their behavioral intentions, empathic concern, and threat; and also highlight the need to further examine age and sex differences regarding responses to homophobic bullying episodes.
Highly Conductive Nitrogen‐Doped sp2/sp3 Hybrid Carbon as a Conductor‐Free Charge Storage Host
Authors: Wang Qi , Su Jincang , Chen Hailun , Wang Deqiang , Tian Xiaoyu , Zhang Yujian , Feng Xin , Wang Shun , Li Jun , Jin Huile 
Published: November 2022

AbstractIt is commonly accepted that the increased degree of graphitization leads to a higher electrical conductivity of carbon materials. However, more and more evidence reveals that heteroatom doping on carbon host can also improve the conductivity, owing to the dopant atoms contributing to higher charge delocalization and density of donor states near Fermi level. The reality is, such conductivity improvement from doping is often overwhelmed by graphitized carbon. Although heteroatom‐doped carbon is widely used as active materials in the fields of energy storage and electrocatalysis, which still requires extra carbon‐based conductive additives to enhance the overall conductivity. In this stu, it is demonstrated that the electrical conductivity of finely designed nitrogen‐doped carbon is even beyond the commercialized carbon conductors over 3.5 times, endowing such conductive agent‐free electrode material an excellent performance in an all‐solid‐state flexible supercapacitor. The theoretical simulation further demonstrates that N‐doped sp2/sp3 hybrid carbon can migrate the Fermi level to the conduction band, leading to an n‐type conductivity due to the additional electrons caused by the N dopant.
Ultrasensitive Perovskite Photodetector for Filter‐Free Color Single‐Pixel Imaging
Authors: Zhang Zhihong , Zheng Peixia , Yan Shan‐Shan , Qiao Bao‐Shi , Ng Kar Wei , Liu Hong‐Chao , Wang Shuang‐Peng , Wei Zhipeng 
Published: November 2022

AbstractFilter‐free color imaging is the long‐pursued solution for its simple structure, low cost, and high stability. However, a spectroscopic unit is still necessary for the current Si‐based imaging unit due to the intrinsic photoresponse properties of Si. Here, the authors demonstrate a filter‐free color‐resolved single‐pixel imaging (SPI) by combining the working mechanism of computational ghost imaging and the response characteristic of perovskite. Benefitting from a broad linear dynamic range (106.5 dB) and a high detectivity (4.03 × 1014 Jones) of the fabricated ultrasensitive MAPbBr3 microwire arrays (MWAs) photodetector, the light attenuation caused by an object can be effectively correlated with its color. The reconstructed images of both transmissive and reflective color objects show a high wavelength resolution reaching 20 nm in the range of 400–540 nm, which is impossible to achieve by commercial silicon‐photodiode‐based ones. This work can open a new door for the image acquisition of color‐sensitive objects and also pave a way for the evolution of the next generation of detectors and cameras with low‐dimensional perovskite materials.
Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always
Authors: Martin W. R. Wayne , Younce John R. , Campbell Meghan C. , Racette Brad A. , Norris Scott A. , Ushe Mwiza , Criswell Susan , Davis Albert A. , Alfradique‐Dunham Isabel , Maiti Baijayanta , Cairns Nigel J. , Perrin Richard J. , Kotzbauer Paul T. , Perlmutter Joel S. 
Published: November 2022

ObjectiveThe objective of this study was to evaluate the relationship between Parkinson's disease (PD) with dementia and cortical proteinopathies in a large population of pathologically confirmed patients with PD.MethodsWe reviewed clinical data from all patients with autopsy data seen in the Movement Disorders Center at Washington University, St. Louis, between 1996 and 2019. All patients with a diagnosis of PD based on neuropathology were included. We used logistic regression and multivariate analysis of covariance (MANCOVA) to investigate the relationship between neuropathology and dementia.ResultsA total of 165 patients with PD met inclusion criteria. Among these, 128 had clinical dementia. Those with dementia had greater mean ages of motor onset and death but equivalent mean disease duration. The delay between motor symptom onset and dementia was 1 year or less in 14 individuals, meeting research diagnostic criteria for possible or probable dementia with Lewy bodies (DLB). Braak Lewy body stage was associated with diagnosis of dementia, whereas severities of Alzheimer's disease neuropathologic change (ADNC) and small vessel pathology did not. Pathology of individuals diagnosed with DLB did not differ significantly from that of other patients with PD with dementia. Six percent of individuals with PD and dementia did not have neocortical Lewy bodies; and 68% of the individuals with PD but without dementia did have neocortical Lewy bodies.InterpretationNeocortical Lewy bodies almost always accompany dementia in PD; however, they also appear in most PD patients without dementia. In some cases, dementia may occur in patients with PD without neocortical Lewy bodies, ADNC, or small vessel disease. Thus, other factors not directly related to these classic neuropathologic features may contribute to PD dementia. ANN NEUROL 2023;93:184–195
Fluor‐Dirigierte Automatisierte Mannosid Assemblierung
Authors: Teschers Charlotte S. , Gilmour Ryan 
Published: November 2022

AbstractDie automatisierte Glykan Assemblierung (AGA) auf festen Trägern ist heutzutage von unschätzbarem Wert, um die biologische Bedeutung komplexer Kohlenhydrate mit den anhaltenden Herausforderungen ihrer Synthese in Einklang zu bringen. Während AGA‐Plattformen die Konstruktion vieler natürlicher Zucker verändert haben, steckt die Validierung der Konstruktion wohldefinierter (positionsselektiv modifizierter) Glykomimetika noch in den Kinderschuhen. Motiviert durch die Bedeutung der Fluorierung in der Arzneimittelforschung, der biomedizinischen Bedeutung von 2‐Fluorzuckern und den bemerkenswerten Selektivitäten der fluorgesteuerten Glykosylierung, wird die Fluor‐dirigierte automatisierte Glykan Assemblierung (FDAGA) entwickelt. Diese Strategie nutzt das Fluoratom für die stereokontrollierte Glykosylierung auf einem festen Träger, wodurch die Abhängigkeit von O‐basierten dirigierenden Gruppen entfällt. Das logische Design von C2‐fluorierten Mannose‐Bausteinen und ihre Anwendung in der vollständig (α‐)stereoelektiven automatisierten Assemblierung von linearen und verzweigten fluorierten Oligomannosiden wird beschrieben. Diese Strategie kann in bestehende AGA‐ und Post‐AGA‐Protokolle integriert werden, um den Anwendungsbereich der programmierten Kohlenhydratsynthese zu erweitern.
Comprehensive investigation on physical and chemical properties of γ‐irradiated multilayer PE/EVOH/PE film: A multiscale approach
Authors: Gaston Fanny , Dupuy Nathalie , Girard‐Perier Nina , Marque Sylvain R. A. , Dorey Samuel 
Published: November 2022

AbstractThe study evaluates findings on the impact of γ‐irradiation on the single‐use, multilayer plastic film that is manufactured for the biotechnological and biopharmaceutical environments. It is comprised of a multilayer film that offers durability and gas (O2, CO2 and H2O) shielding properties. Polyethylene (PE) and ethylene vinyl alcohol (EVOH) are the parts within this film, which as a whole, is PE/EVOH/PE. The impact of γ‐irradiation on the nonirradiated and γ‐irradiated (from 30 kGy up to 270 kGy) PE multilayer film is investigated by colorimetry measurement, Fourier transform infrared and Raman spectroscopies, pH measurement, ion chromatography and conductivity measurement, tensile tests, X‐ray photoelectron spectroscopy, differential scanning, and oxygen and water vapor transmission rate. AComDim and Principal Components Analysis are two chemometric tools that are utilized to understand both physical and chemical changes, along with the main factors contributing to polymer degradation in the PE multilayer film while under γ‐irradiation.
Left ventricular pseudoaneurysm secondary to recurrent mitral prosthetic valve endocarditis
Authors: Nishiori Hironobu , Matsumiya Goro 
Published: November 2022

AbstractAn 86‐year‐old man who had undergone two mitral valve replacements developed heart failure due to prosthetic valve infection and left ventricular pseudoaneurysm (LVPA). LVPA due to infective endocarditis is rare and caused by the abscess formation in the left ventricular myocardium. Infective endocarditis caused by enterococci requires attention to relapse.
Vibrational Circular Dichroism Unravels Supramolecular Chirality and Hydration Polymorphism of Nucleoside Crystals
Authors: Krupová Monika , Leszczenko Patrycja , Sierka Ewa , Emma Hamplová Sára , Pelc Radek , Andrushchenko Valery 
Published: November 2022

AbstractInvited for the cover of this issue are Valery Andrushchenko, Monika Krupová, and co‐workers at the Institute of Organic Chemistry and Biochemistry (IOCB Prague) of the Czech Academy of Sciences. The image depicts a “crystal city” illuminated by “chiral suns” shining left‐ and right‐circularly polarized light (L‐CPL and R‐CPL), which reveals differences in the structure of the chiral crystalline “skyscrapers”. Designed by Tomáš Belloň @ IOCB Prague. Read the full text of the article at 10.1002/chem.202201922.
Smart Phototheranostics based on Carbon Nanohorns for Precise Imaging‐Guided Post‐PDT toward Residual Tumor Cells after Initial Phototherapy
Authors: Zhang Hengming , Zhu Chengyuan , Liang Jiawei , Li Shuzhen , Hu Lan‐Fang , Liang Hong , Kuo Wen‐Shuo , Shen Xing‐Can 
Published: November 2022

AbstractAs promising photonic material, phototheranostics can be activated in the laser irradiation range of tumor with sensitivity and spatiotemporal precision. However, it is difficult to completely eradicate solid tumors due to their irregularity and limited laser irradiation area. Herein, multi‐stimulus responsive HA−Ce6@SWNHs were constructed with single‐walled carbon nanohorns (SWNHs) and chlorine e6 (Ce6) modified hyaluronic acid (HA) via non‐covalent binding. This SWNHs‐based phototheranostics not only exhibited water dispersion but also could target tumor and be activated by near‐infrared light for photodynamic therapy (PDT) and photothermal therapy (PTT). Additionally, HA−Ce6@SWNHs could be degraded by hyaluronidase in residual tumor cells, causing HA−Ce6 to fall off the SWNHs surfaces to restore autofluorescence, thus precisely guiding the programmed photodynamic treatments for residual tumor cells after the initial phototherapy. Thus, this work provides a rationally designed multiple‐stimulus‐response strategy to develop smart SWNHs‐based phototheranostics for precise PDT/PTT and post‐treatment imaging‐guided PDT of residual tumor cells.
Luminescent Crystalline Carbon‐ and Nitrogen‐Centered Organic Radicals Based on N‐Heterocyclic Carbene‐Triphenylamine Hybrids
Authors: Li Xin , Wang Yi‐Lin , Chen Can , Han Ying‐Feng 
Published: November 2022

AbstractDeveloping luminescent radicals with tunable emission is a challenging task due to the limitation of alternative skeletons. Herein, a series of carbene‐triphenylamine hybrids were prepared by the direct C2‐arylation of N‐heterocyclic carbenes with 4‐bromo‐N,N‐bis(4‐methoxyphenyl)aniline. These hybrids showed multiple redox‐active properties and could be converted to carbon‐centered luminescent radicals with blue‐to‐cyan emissions (λmax: 436–486 nm) or nitrogen‐centered luminescent radicals with orange emissions (λmax: 590–623 nm) through chemical reduction or oxidation, respectively. The radical species were characterized by electron paramagnetic resonance spectroscopy, ultraviolet‐visible spectroscopy, and single‐crystal X‐ray diffractometry analysis. Notably, the corresponding nitrogen‐centered radicals exhibited good stability in atmospheric air, and their thermal decomposition temperatures were determined to be above 200 °C. In addition, spectral and theoretical calculations indicate that all radicals exhibit anti‐Kasha emissions.
Edge‐driven ubiquitous wireless communication for robust cluster intelligent piano presentation platform considering system security
Authors: Wang Qi 
Published: November 2022

SummaryWith the popularization of 6G‐driven wireless access networks and the development of edge computing, the connection between piano performance and artificial intelligence algorithms is getting closer and closer. 6G was first used to solve large‐capacity, short‐latency communication problems, and research results in this field abound. However, in practical applications, the deployment of 6G high‐frequency network is a major problem faced by the industry. This paper mainly studies the artificial robust cluster piano demonstration platform from the perspective of the fusion of 6G and edge computing. We firstly consider that the edge computing is a technology in which artificial intelligence algorithms are transplanted to edge devices and chips. The vision of the 6G network is to realize ubiquitous wireless intelligence, which includes three dimensions: mobile ultra‐broadband, super Internet of Things, and artificial intelligence, and realizes the conversion of piano scores into digital signals. Artificial Robust Clustering is a comprehensive technique that incorporates many disciplines, including phonetics, artificial intelligence, computer science, and more. This paper analyzes the fusion technology of 6G and edge computing and studies the robust cluster intelligent piano demonstration platform. The mentioned technologies are combined together to make the designed efficient.
Myoepithelial carcinoma of the parotid gland with a novel CTCF::NCOA2 fusion
Authors: Gandhi Jatin , Mantilla Jose G. , Ricciotti Robert W. , Chen Eleanor Y. , Liu Yajuan J. , Bandhlish Anshu 
Published: November 2022

AbstractWe describe a case of a myoepithelial carcinoma of the superficial parotid gland in a 46‐year‐old male harboring a novel CTCF::NCOA2 gene fusion. To our knowledge, this novel gene fusion has not been described previously in myoepithelial carcinoma. A 46‐year‐old male patient presented with a mass involving the superficial left parotid gland with extension into the external auditory canal (EAC) and erosion of the conchal cartilage. Histologically, the neoplasm was composed of uniform spindled, epithelioid/ovoid cells arranged in cords and nests within hyalinized to myxoid stroma. On immunohistochemistry (IHC), the tumor cells demonstrated patchy and variable staining for low molecular weight cytokeratin (CAM5.2), pan‐cytokeratin (OSCAR), and S‐100. Overall, the morphological and immunohistochemical attributes supported a locally aggressive tumor of myoepithelial differentiation consistent with myoepithelial carcinoma. Molecular analysis using a custom 115‐gene gene panel by targeted RNA sequencing, showed an in‐frame CTCF::NCOA2 fusion. In addition to reporting this novel fusion in myoepithelial carcinoma, we also discuss relevant differential diagnosis, and provide a brief review of NCOA2 gene function in both normal and neoplastic contexts.
Palaeomagnetic constraints on a Late Permian to Early Triassic final closure of thePalaeo‐AsianOcean
Authors: Zhang Donghai , Zhao Guochun , Huang Baochun , Zhao Jie , Zhao Qian 
Published: November 2022

AbstractFinal closure of the Palaeo‐Asian Ocean signifies the ultimate amalgamation of the North China, Tarim, Mongolia, Songliao, Xilinhot and other Central Asian blocks, and therefore, is critical in reconstructing the configuration of the Pangea supercontinent during the late Palaeozoic to early Mesozoic. However, the final closure time remains contentious. Here, we present a systematic palaeomagnetic study on the Upper Permian sedimentary sequences of the Xilinhot Block, located to the north of the Solonker Suture Zone. Rock magnetic results indicate stable pseudo‐domain magnetite is the dominant magnetic carrier. The characteristic components isolated between ~350 and 590°C display the existence of dual polarities. Combined with previous results, the merged site‐mean directions yield a negative reversal test and inconclusive fold tests. By comparing with coeval and posterior data, and correlating with stitching plutons that intruded the sampling sections, we argue for a remagnetization origin for the newly obtained data, which is most likely acquired during the thermal event when the stitching granitic plutons intruded at 242.0 ± 3.7 Ma. Then we synthesized available palaeomagnetic data from the Central Asian Orogenic Belt and adjacent blocks, and propose a Late Permian to Early Triassic final closure of the Palaeo‐Asian Ocean. Our reconstruction of Pangea in the Early Triassic negates the existence of a cut‐through seaway between the Mongol‐Okhotsk and Palaeo‐Asian Oceans. The Mongol‐Okhotsk Ocean was an extension of Panthalassa, in trumpet‐shaped and faced to the east, rather than an individual oceanic basin separating Siberia from the Cinamuria Block.