bluuebunny/crossref_metadata_2025_split huggingface dataset:
Keterhubungan pelangi kuat operasi korona graf berlian dan graf lintasan dengan Tikz
Authors: Maulani Alfi 
Published: July 2022

Salah satu kasus pewarnaan sisi dalam teori graf yaitu bilangan keterhubungan pelangi kuat. Banyaknya minimum warna yang dibutuhkan untuk mewarnai sisi-sisi di H agar setiap pasangan simpul dapat dihubungkan oleh lintasan geodesik (lintasan terpendek) yang berbeda warna disebut bilangan keterhubungan pelangi kuat dari graf H, yang dinyatakan sebagai src(H). Selanjutnya, diperlukan operasi korona pada graf dengan menggunakan n salinan P1,P2,...,Pn dari Pm dan 1 (satu) salinan dari graf Brn guna menghasilkan graf Brn korona Pm yang strukturnya diperoleh setelah menghubungkan setiap simpul dari Brn ke masing-masing simpul di Pi. Metode studi literatur digunakan dalam penelitian ini. Penelitian ini menghasilkan nilai-nilai eksak atau bilangan keterhubungan pelangi kuat dari operasi korona graf berlian Br4 dan graf lintasan Pm, dinotasikan dengan src(Br4 korona Pm), disertai dengan visualisasi src(Br4 korona Pm) menggunakan salah satu aplikasi Latex yaitu Tikz.
Koneksi Produktif Matematis Mahasiswa dalam Menyelesaikan Soal Kalkulus Berdasarkan Kemampuan Matematika
Authors: Suharna Hery , Hairun Yahya , Angkotasan Nurma 
Published: July 2022

Berpikir koneksi matematis penelitian yang menarik untuk di angkat dalam suatu penelitian. Koneksi matematis pada tingkatan universitas juga sering mengalami kesulitan dalam mengontruksi koneksi matematis, masalah yang dihadapi mahasiswa diantaranya yaitu: 1) Ketidaksesuian struktur masalah dengan struktur berpikir atau sering disebut juga dengan disekuilibrium (disekuilibrasi) pada memori jangka panjang mahasiswa; 2) Ketidaklengkapan (ketidak sesuaian) pengetahuan awal yang dimiliki oleh mahasiswa tentang konsep-konsep matematika yang bersyarat; dan 3) Struktur koneksi matematis dalam mengonseptualisasi struktur masalah matematis mahasiswa ketika menyelesaikan masalah matematis. Penelitian ini mengangkat masalah bagaimana koneksi produktif mahasiswa ketika menyelesaikan soal kalkulus berdasarkan jenis kelamin (laki-laki dan perempuan). Metode penelitian yang digunakan dalam mengungkap permasalahan tersebut yaitu bersifat deskriptif eksploratif. Subjek dalam penelitian ini adalah mahasiswa matematika semester 4 program studi pendidikan matematika Universitas Khairun yang terbagi menjadi empat yaitu 2 laki dan 2 perempuan, pada artikel ini mendeskripsikan antara laki-laki dan perempuan. Teknik analisis data penelitian yang digunakan adalah deskriptif kualitatif menurut Creswell tahun 2010 yaitu (1) mengolah dan mempersiapkan; (2) membaca keseluruhan data; (3) menganalisis lebih detail dengan men-coding data, (4) terapan proses coding, mendeskripsikan dan tema-tema ini akan disajikan kembali dalam narasi/laporan kualitatif; dan (5) menginterpretasikan atau memaknai data.Koneksi produktif matematis berdasarkan jenis kelamin perempuan yaitu diawali denga terjadinya disekuilibrasi melakukan penyelesaian dengan cara yang unik. Selanjutnya koneksi produktif laki-laki yaitu diawali dengan disekuilibrasi dan selanjutnya melakukan penyelesaian dengan cara mencoba-coba dengan berulang kali. Kata kunci : Rekontruksi, struktur koneksi, koneksi produktif dan jenis kelamin
Eksplorasi etnomatematika masyarakat Desa Sondo-Sondo Kecamatan Wasile Selatan pada permainan SEM
Authors: Saidi Soleman , Suratmi Lily , La Nani Karman , Tamrin Bakar Marwia , Kurnia Waliyanti Ida , Sadaralam Safruddin 
Published: July 2022

Abstrak. Etnomatematika menjadi topik yang selalu menarik dan penting untuk dikaji sebagai bentuk apresiasi peneliti terhadap budaya lokal yang selama ini sudah mulai ditinggalkan karena kemajuan teknologi. Tujuan penelitian untuk mendeskripsikan unsur-unsur etnomatematika yang terkandung didalam permainan SEM. Jenis penelitian adalah etnografi dengan pendekatan kualitatif. Fokus penelitian ini yaitu petak permainan SEM, aturan bermain, dan pemain SEM. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Penelitian ini menggunakan analisis data triangulasi yang terdiri dari reduksi data, penyajian dan penarikan kesimpulan. Hasil penelitian menunjukkan terdapatnya unsur-unsur etnomatematika pada permainan SEM berupa geometri, konsep garis, hubungan antar sudut dan konsep peluang. Kata kunci : etnomatematika, permainan SEM.
KEEFEKTIFAN MODEL PROBLEM-BASED LEARNING DITINJAU DARI KEMAMPUAN PEMECAHAN MASALAH MATEMATIS
Authors: Angkotasan Nurma 
Published: July 2022

Penelitian ini bertujuan untuk mendeskripsikan keefektifan model Problem-Based Learning ditinjau dari kemampuan pemecahan masalah matematis pada siswa SMA Negeri 5 Kota Ternate. Jenis penelitian yang digunakan adalah penelitian eksperimen semu, yang terdiri dari satu kelompok eksperimen. Adapun sampel yang diperoleh yaitu siswa kelas XII IPA1 SMA N 5 Kota Ternate. Instrumen yang digunakan adalah instrumen tes yang terdiri atas soal tes kemampuan pemecahan masalah matematis. Untuk mengetahui keefektifan model Problem-Based Learning pada variabel kemampuan pemecahan masalah matematis digunakan uji one samples t-test. Hasil penelitian menunjukkan bahwa model Problem-Based Learning efektif ditinjau dari kemampuan pemecahan masalah matematis siswa.
BERPIKIR KONEKSI RELATIF KOMPLEKS DALAM MENYELESAIKAN MASALAH MATEMATIKA
Authors: Suharna Hery , Hi. Abdullah Nurningsih 
Published: July 2022

Tujuan dari artikel ini adalah untuk mendeskripsikan tentang koneksi matematis relatif melalui reflektif mahasiswa dalam menyelesaikan masalah matematika. Berpikir koneksi yang perlu digaris bawahi yaitu: (1) Mahasiswa mengalami kesulitan dalam menghubungkan konsep-konsep matematika pada struktur berpikir, (2) Mahasiswa tidak membuat koneksi matematika kaitannya dengan aplikasi matematika, karena mereka tidak pernah diajarkan bagaimana aplikasi matematika, (3) Menyelesaikan masalah matematika merupakan sarana dalam melatih koneksi matematis. NCTM menyatakan tentang pentingnya koneksi dalam matematika yaitu pemecahan masalah (problem solving), penalaran dan bukti (reasoning and proof), komunikasi (communication), koneksi (connections), dan representasi (representation).Jenis penelitian ini adalah deskriptif dengan pendekatan kualitatif, pemilihan subjek penelitian yaitu snow ball. Hasil penelitian menemukan bahwa berpikir koneksi matematis bersifat relatif yaitu berpikir yang diawali dengan ketidaklengkapan struktur berpikir dengan masalah. Proses refleksi untuk menyesuaikan struktur masalah yang dimiliki dan selanjutnya melakukan koneksi yang bersifat relatif untuk menemukan penyelesaian masalah matematika. Proses berpikir koneksi yang dipengaruhi oleh proses refleksi ketika menyelesaikan masalah matematis. Kata kunci :Berpikir koneksi, menyelesaikan masalah, koneksi relatif, dan reflektif
Hidden Addressing Encoding for DNA Storage
Authors: Wang Penghao , Mu Ziniu , Sun Lijun , Si Shuqing , Wang Bin 
Published: July 2022

DNA is a natural storage medium with the advantages of high storage density and long service life compared with traditional media. DNA storage can meet the current storage requirements for massive data. Owing to the limitations of the DNA storage technology, the data need to be converted into short DNA sequences for storage. However, in the process, a large amount of physical redundancy will be generated to index short DNA sequences. To reduce redundancy, this study proposes a DNA storage encoding scheme with hidden addressing. Using the improved fountain encoding scheme, the index replaces part of the data to realize hidden addresses, and then, a 10.1 MB file is encoded with the hidden addressing. First, the Dottup dot plot generator and the Jaccard similarity coefficient analyze the overall self-similarity of the encoding sequence index, and then the sequence fragments of GC content are used to verify the performance of this scheme. The final results show that the encoding scheme indexes with overall lower self-similarity, and the local thermodynamic properties of the sequence are better. The hidden addressing encoding scheme proposed can not only improve the utilization of bases but also ensure the correct rate of DNA storage during the sequencing and decoding processes.
Sex Differences in Depression and Sleep Disturbance as Inter-Related Risk Factors of Diabetes
Authors: Li Clara S. , Porta Rose , Chaudhary Shefali 
Published: July 2022

ObjectivesPrevious studies identified depression and sleep disturbance as risk factors for diabetes. Sleep disturbance and depression are known to be inter-related. Further, women relative to men are more prone to depression. Here, we investigated how depression and sleep disturbance may jointly influence the risk of diabetes and the effects of sex on these influences.MethodsUsing the data of 21,229 participants from the 2018 National Health Interview Survey, we performed multivariate logistic regression with diabetes diagnosis as the dependent variable, sex, self-reported frequency of weekly depression and nightly sleep duration, and their interactions with sex as independent variables, and age, race, income, body mass index and physical activity as covariates. We employed Bayesian and Akaike Information criteria to identify the best model, evaluated the accuracy of the model in predicting diabetes using receiver operating characteristic analysis, and computed the odds ratios of these risk factors.ResultsIn the two best models, depression frequency and sleep hours interact with sex in determining the diagnosis of diabetes, with higher depression frequency and nightly duration of sleep longer or shorter than 7 to 8 hours associated with higher likelihood of diabetes. The two models both predicted diabetes at an accuracy (area under the receiver operating characteristic curve) of 0.86. Further, these effects were stronger in men than in women at each depression and sleep level.ConclusionsDepression and sleep inter-relatedly rather than independently contributes to diabetes. Depression and sleep hours associate with diabetes more significantly in men than in women. The current findings indicate a sex-dependent relationship between depression, sleep disturbance and diabetes risk and add to a growing body of evidence linking mental and physical health.
Air Pollution’s Impact on Cardiac Remodeling in an Experimental Model of Chagas Cardiomyopathy
Authors: Fonseca Keila Cardoso Barbosa , Pessoa Fernanda Gallinaro , Ribeiro Orlando do Nascimento , Hotta Viviane Tiemi , Ianni Barbara Maria , Fernandes Fabio , Ferreira Rivero Dolores Helena Rodriguez , Saldiva Paulo Hilário Nascimento , Mady Charles , Ramires Felix José Alvarez 
Published: July 2022

BackgroundChagas disease is characterized by intense myocardial fibrosis stimulated by the exacerbated production of inflammatory cytokines, oxidative stress, and apoptosis. Air pollution is a serious public health problem and also follows this same path. Therefore, air pollution might amplify the inflammatory response of Chagas disease and increase myocardial fibrosis.MethodsWe studied groups of Trypanosoma cruzi infected Sirius hamsters (Chagas=CH and Chagas exposed to pollution=CH+P) and 2 control groups (control healthy animals=CT and control exposed to pollution=CT+P). We evaluated acute phase (60 days post infection) and chronic phase (10 months). Echocardiograms were performed to assess left ventricular systolic and diastolic diameter, in addition to ejection fraction. Interstitial collagen was measured by morphometry in picrosirius red staining tissue. The evaluation of inflammation was performed by gene and protein expression of cytokines IL10, IFN-γ, and TNF; oxidative stress was quantified by gene expression of NOX1, MnSOD, and iNOS and by analysis of reactive oxygen species; and apoptosis was performed by gene expression of BCL2 and Capsase3, in addition to TUNEL analysis.ResultsChagas groups had increased collagen deposition mainly in the acute phase, but air pollution did not increase this deposition. Also, Chagas groups had lower ejection fraction in the acute phase (p = 0.002) and again air pollution did not worsen ventricular function or dilation. The analysis of the inflammation and oxidative stress pathways were also not amplified by air pollution. Apoptosis analysis showed increased expression of BCL2 and Caspase3 genes in chagasic groups in the acute phase, with a marginal p of 0.054 in BCL2 expression among infected groups, and TUNEL technique showed amplified of apoptotic cells by pollution among infected groups.ConclusionsA possible modulation of the apoptotic pathway was observed, inferring interference from air pollution in this pathway. However, it was not enough to promote a greater collagen deposition, or worsening ventricular function or dilation caused by air pollution in this model of Chagas cardiomyopathy.
Increased TGFβ1 and SMAD3 Contribute to Age-Related Aortic Valve Calcification
Authors: Chakrabarti Mrinmay , Bhattacharya Aniket , Gebere Mengistu G. , Johnson John , Ayub Zeeshan A. , Chatzistamou Ioulia , Vyavahare Narendra R. , Azhar Mohamad 
Published: July 2022

AimsCalcific aortic valve disease (CAVD) is a progressive heart disease that is particularly prevalent in elderly patients. The current treatment of CAVD is surgical valve replacement, but this is not a permanent solution, and it is very challenging for elderly patients. Thus, a pharmacological intervention for CAVD may be beneficial. In this study, we intended to rescue aortic valve (AV) calcification through inhibition of TGFβ1 and SMAD3 signaling pathways.Methods and ResultsThe klotho gene, which was discovered as an aging-suppressor gene, has been observed to play a crucial role in AV calcification. The klotho knockout (Kl–/–) mice have shorter life span (8–12 weeks) and develop severe AV calcification. Here, we showed that increased TGFβ1 and TGFβ-dependent SMAD3 signaling were associated with AV calcification in Kl–/– mice. Next, we generated Tgfb1- and Smad3-haploinsufficient Kl–/– mice to determine the contribution of TGFβ1 and SMAD3 to the AV calcification in Kl–/– mice. The histological and morphometric evaluation suggested a significant reduction of AV calcification in Kl–/–; Tgfb1± mice compared to Kl–/– mice. Smad3 heterozygous deletion was observed to be more potent in reducing AV calcification in Kl–/– mice compared to the Kl–/–; Tgfb1± mice. We observed significant inhibition of Tgfb1, Pai1, Bmp2, Alk2, Spp1, and Runx2 mRNA expression in Kl–/–; Tgfb1± and Kl–/–; Smad3± mice compared to Kl–/– mice. Western blot analysis confirmed that the inhibition of TGFβ canonical and non-canonical signaling pathways were associated with the rescue of AV calcification of both Kl–/–; Tgfb1± and Kl–/–; Smad3± mice.ConclusionOverall, inhibition of the TGFβ1-dependent SMAD3 signaling pathway significantly blocks the development of AV calcification in Kl–/– mice. This information is useful in understanding the signaling mechanisms involved in CAVD.
Anti-embolism devices therapy to improve the ICU mortality rate of patients with acute myocardial infarction and type II diabetes mellitus
Authors: Huang Xiaxuan , Zhang Luming , Xu Mengyuan , Yuan Shiqi , Ye Yan , Huang Tao , Yin Haiyan , Lyu Jun 
Published: July 2022

BackgroundAnti-Embolism (AE) devices therapy is an additional antithrombotic treatment that is effective in many venous diseases, but the correlations between this medical compression therapy and cardiovascular arterial disease or comorbid diabetes mellitus (DM) are still controversial. In this study we investigated the association between compression therapy and intensive care unit (ICU) mortality in patients with a first acute myocardial infarction (AMI) diagnosis complicated with type II DM.MethodsThis retrospective cohort study analyzed all patients with AMI and type II DM in the Medical Information Mart for Intensive Care-IV database. We extracted the demographics, vital signs, laboratory test results, comorbidities, and scoring system results of patients from the first 24 h after ICU admission. The outcomes of this study were 28-day mortality and ICU mortality. Analyses included Kaplan–Meier survival analysis, Cox proportional-hazards regression, and subgroup analysis.ResultsThe study included 985 eligible patients with AMI and type II DM, of who 293 and 692 were enrolled into the no-AE device therapy and AE device therapy groups, respectively. In the multivariate analysis, compared with no-AE device therapy, AE device therapy was a significant predictor of ICU mortality (HR = 0.48, 95% CI = 0.24–0.96, P = 0.039) and 28-day mortality (HR = 0.50, 95% CI = 0.27–0.90, P = 0.021). In addition to age, gender and coronary artery bypass grafting surgery, there were no significant interactions of AE device therapy and other related risk factors with ICU mortality and 28-day mortality in the subgroup analysis.ConclusionsSimple-AE-device therapy was associated with reduced risks of ICU mortality and 28-day mortality, as well as an improvement in the benefit on in-hospital survival in patients with AMI complicated with type II DM.
Sarcopenic Obesity in Individuals With Neurodisabilities: The SarcObeNDS Study
Authors: Dionyssiotis Yannis , Prokopidis Konstantinos , Trovas George , Papadatou Maria-Christina , Ananidis Nikolaos , Tragoulias Vasileios , Lazarou Eleni , Christaki Evangelia , Domazou Marilena , Galanos Antonios , Tyllianakis Minos 
Published: July 2022

IntroductionPatients with neurodisabilities (NDS) are prone to alterations in body composition. Sarcopenic obesity (SO) is a condition characterized by increased adipose tissue accompanied by sarcopenia. The aim of this study was to investigate the prevalence of SO in patients with NDS, including stroke, spinal cord, and traumatic brain injuries.MethodsThe study Sarcopenic Obesity in NeuroDisabled Subjects (acronym: SarcObeNDS) was a cross-sectional study of hospitalized patients (n = 82) and healthy controls (n = 32) with a mean age of 60.00 ± 14.22 years old. SO and sarcopenia were assessed through total body fat % (TBF %), fat mass index (fat mass to height2: FMI = FM/h2; kg/m2), and skeletal muscle index (appendicular skeletal muscle to height2: SMI = ASM/h2; kg/m2) via full-body dual-energy X-ray absorptiometry (DXA). This study was registered in the international database ClinicalTrials.gov with the unique identification number NCT03863379.ResultsA statistically significant difference was found in SMI (7.18 ± 0.95 vs. 6.00 ± 1.13 kg/m2, p &lt; 0.001) between controls and patients with NDS. No statistical significance was found for TBF (p = 0.783) and FMI (p = 0.143) between groups. The results remained the same after controlling the results for gender and BMI. A strong positive correlation was demonstrated between BMI and TBF for the total population (r = 0.616, p &lt; 0.001), the control group (r = 0.616, p &lt; 0.001), and patients with NDS (r = 0.728, p &lt; 0.001).ConclusionIn summary, we observed significantly lower BMI and SMI scores in both genders compared to healthy controls. At the clinical level, a timely diagnosis and rapid treatment of sarcopenia and/or obesity in this population may prevent further metabolic repercussions accompanied by higher functional decline and lower quality of life.
Global, Regional and National Burden of Cancers Attributable to High Fasting Plasma Glucose in 204 Countries and Territories, 1990-2019
Authors: Safiri Saeid , Nejadghaderi Seyed Aria , Karamzad Nahid , Kaufman Jay S. , Carson-Chahhoud Kristin , Bragazzi Nicola Luigi , Sullman Mark J. M. , Beyranvand Mohammad Reza , Mansournia Mohammad Ali , Almasi-Hashiani Amir , Collins Gary S. , Kolahi Ali-Asghar 
Published: July 2022

BackgroundTo report the burden of cancers attributable to high fasting plasma glucose (HFPG) by sex, age, location, cancer type and Socio-demographic Index (SDI) over the period 1990 to 2019 for 204 countries and territories.MethodsUsing the Comparative Risk Assessment approach of Global Burden of Disease (GBD) study 2019, the burden of cancers attributable to HFPG was reported in 1990 and 2019.ResultsGlobally, in 2019 there were an estimated 419.3 thousand cancer deaths (95% UI: 115.7 to 848.5) and 8.6 million cancer DALYs (2.4 to 17.6) attributable to HFPG. By sex, 4.6 (1.1 to 9.9) and 4.0 (1.1 to 8.4) million global cancer DALYs were attributable to HFPG in men and women, respectively. The global age-standardized death and DALY rates of cancers attributable to HFPG (per 100,000) have increased by 27.8% (20.5 to 38.7%) and 24.5% (16.4 to 35.6%), respectively, since 1990. High-income North America (9.5 [2.7 to 18.8]) and Eastern Sub-Saharan Africa (2.0 [0.5 to 4.2]) had the highest and lowest regional age-standardized death rates, respectively, for cancers attributable to HFPG. In 2019, the global number of attributable cancer DALYs were highest in 65-69 age group. Moreover, there was an overall positive association between SDI and the regional age-standardized DALY rate for HFPG-attributable cancers.ConclusionsHFPG was associated with more burden in 2019. Preventive programs for diabetes and screening of individuals with diabetes for cancers, especially in older males living in developed countries, are required to arrest the large increases in HFPG-attributable cancers.
The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
Authors: Xu Min , Qi Yan , Chen Gang , Qin Yingfen , Wu Shengli , Wang Tiange , Zhao Zhiyun , Xu Yu , Li Mian , Chen Li , Chen Lulu , Chen Yuhong , Deng Huacong , Gao Zhengnan , Huo Yanan , Li Qiang , Liu Chao , Luo Zuojie , Mu Yiming , Qin Guijun , Shen Feixia , Shi Lixin , Su Qing , Wan Qin , Wang Guixia , Wang Shuangyuan , Wang Youmin , Hu Ruying , Xu Yiping , Yan Li , Yang Tao , Yu Xuefeng , Zhang Yinfei , Zeng Tianshu , Tang Xulei , Ye Zhen , Zhao Jiajun , Bi Yufang , Ning Guang , Lu Jieli , Wang Weiqing 
Published: July 2022

AimTo determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk.Methods35,611 non-diabetic participants aged ≥ 50 years from a well-defined nationwide cohort were followed up for average of 3.6 years, with cardiovascular diseases and cancers at baseline were excluded. Body weight at 20, 30, 40, and 50 years was reported. The overall 30 years and each 10-year weight gain were calculated from the early and middle life. Cox regression models were used to estimate risks of incident diabetes.ResultsAfter 127,745.26 person-years of follow-up, 2,789 incident diabetes were identified (incidence rate, 2.18%) in 25,289 women (mean weight gain 20-50 years, 7.60 kg) and 10,322 men (7.93 kg). Each 10-kg weight gain over the 30 years was significantly associated with a 39.7% increased risk of incident diabetes (95% confidence interval [CI], 1.33-1.47); weight gain from 20-30 years showed a more prominent effect on the risk of developing diabetes before 60 years than that of after 60 years (Hazard ratio, HR = 1.084, 95% CI [1.049-1.121], P &lt;0.0001 vs. 1.015 [0.975-1.056], P = 0.4643; PInteraction=0.0293). It showed a stable effect of the three 10-year intervals weight gain on risk of diabetes after 60 years (HR=1.055, 1.038, 1.043, respectively, all P &lt; 0.0036).ConclusionsThe early life weight gain showed a more prominent effect on developing diabetes before 60 years than after 60 years; however, each-decade weight gain from 20 to 50 years showed a similar effect on risk developing diabetes after 60 years.