bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of antibiotic resistance genes in the oral cavity and mobile genetic elements that disseminate antimicrobial resistance: A systematic review
Authors: Brooks Laura , Narvekar Unnati , McDonald Ailbhe , Mullany Peter 
Published: June 2022

AbstractThe objective of this review was to assess the prevalence of antibiotic resistance genes in the oral cavity and identify mobile genetic elements (MGEs) important in disseminating them. Additionally, to assess if age, geographic location, oral site, bacterial strains and oral disease influence the prevalence of these genes. Three electronic databases (Medline, Embase and the Cochrane Library) were used to search the literature. Journals and the grey literature were also hand searched. English language studies from January 2000 to November 2020 were selected. Primary screening was performed on the titles and abstracts of 1509 articles generated. One hundred and forty‐seven full texts were obtained to conduct the second screening with strict inclusion and exclusion criteria. Forty‐four final articles agreed with the inclusion criteria. Half of the studies were classed as low quality. tet(M) was the most prevalent gene overall and the conjugative transposon Tn916 the most common MGE associated with antibiotic resistance genes in the oral cavity. In babies delivered vaginally, tet(M) was more prevalent, whilst tet(Q) was more prevalent in those delivered by C‐section. Generally, countries with higher consumption of antibiotics had higher numbers of antibiotic resistance genes. Agricultural as well as medical use of antibiotics in a country should always be considered. Between healthy, periodontitis and peri‐implantitis subjects, there was no difference in the prevalence of tet(M); however, erm(B), tet(M) and tet(O) were higher in carious active children than the non‐carious group. Subjects with poor oral hygiene have more pathogenic bacteria that carry resistance genes compared to those with good oral hygiene. Enterococcus faecalis isolates demonstrated significant tetracycline resistance (tet(M) up to 60% prevalence in samples) and erythromycin resistance (erm(B) up to 61.9% prevalence in samples), periodontal pathogens showed significant beta‐lactam resistance with blaZ and cfxA present in up to 90%–97% of samples and the normal oral flora had a high level of erythromycin resistance with mef(A/E) present in 65% of Streptococcus salivarius isolates. The most common resistance gene was tet(M) in root canals, cfxA in subgingival plaque, erm(B) in supragingival plaque and tet(W) in 100% of whole saliva samples. The review highlights that although many studies in this area have been performed, 50% were classed as low quality. We advise the following recommendations to allow firm conclusions to be drawn from future work: the use of large sample sizes, investigate a broad range of antibiotic resistance genes, improved methodologies and reporting to improve the quality of genetic testing in microbiology and randomisation of subject selection.
Temporal and geographical variations in survival of children born with congenital anomalies in Europe: A multi‐registry cohort study
Authors: Santoro Michele , Coi Alessio , Pierini Anna , Rankin Judith , Glinianaia Svetlana V. , Tan Joachim , Reid Abigail , Garne Ester , Loane Maria , Given Joanne , Aizpurua Amaia , Astolfi Gianni , Barisic Ingeborg , Cavero‐Carbonell Clara , de Walle Hermien E. K. , Den Hond Elly , García‐Villodre Laura , Gatt Miriam , Gissler Mika , Jordan Sue , Khoshnood Babak , Kiuru‐Kuhlefelt Sonja , Klungsøyr Kari , Lelong Nathalie , Lutke Renée , Mokoroa Olatz , Nelen Vera , Neville Amanda J. , Odak Ljubica , Rissmann Anke , Scanlon Ieuan , Urhoj Stine Kjaer , Wellesley Diana , Wertelecki Wladimir , Yevtushok Lyubov , Morris Joan K. 
Published: June 2022

AbstractBackgroundCongenital anomalies are a major cause of perinatal, neonatal and infant mortality.ObjectivesThe aim was to investigate temporal changes and geographical variation in survival of children with major congenital anomalies (CA) in different European areas.MethodsIn this population‐based linkage cohort study, 17 CA registries members of EUROCAT, the European network for the surveillance of CAs, successfully linked data on 115,219 live births with CAs to mortality records. Registries estimated Kaplan–Meier survival at 28 days and 5 years of age and fitted Cox's proportional hazards models comparing mortality at 1 year and 1–9 years of age for children born during 2005–2014 with those born during 1995–2004. The hazard ratios (HR) from each registry were combined centrally using a random‐effects model. The 5‐year survival conditional on having survived to 28 days of age was calculated.ResultsThe overall risk of death by 1 year of age for children born with any major CA in 2005–2014 decreased compared to 1995–2004 (HR 0.68, 95% confidence interval [CI] 0.53, 0.89). Survival at 5 years of age ranged between registries from 97.6% to 87.0%. The lowest survival was observed for the registry of OMNI‐Net (Ukraine) (87.0%, 95% CI 86.1, 87.9).ConclusionsSurvival of children with CAs improved for births in 2005–2014 compared with 1995–2004. The use of CA registry data linked to mortality data enables investigation of survival of children with CAs. Factors such as defining major CAs, proportion of terminations of pregnancy for foetal anomaly, source of mortality data and linkage methods are important to consider in the design of future studies and in the interpretation of the results on survival of children with CAs.
Dynamic modeling of public and private decision‐making for hurricane risk management including insurance, acquisition, and mitigation policy
Authors: Guo Cen , Nozick Linda , Kruse Jamie , Millea Meghan , Davidson Rachel , Trainor Joseph 
Published: June 2022

AbstractWe develop a computational framework for the stochastic and dynamic modeling of regional natural catastrophe losses with an insurance industry to support government decision‐making for hurricane risk management. The analysis captures the temporal changes in the building inventory due to the acquisition (buyouts) of high‐risk properties and the vulnerability of the building stock due to retrofit mitigation decisions. The system is comprised of a set of interacting models to (1) simulate hazard events; (2) estimate regional hurricane‐induced losses from each hazard event based on an evolving building inventory; (3) capture acquisition offer acceptance, retrofit implementation, and insurance purchase behaviors of homeowners; and (4) represent an insurance market sensitive to demand with strategically interrelated primary insurers. This framework is linked to a simulation‐optimization model to optimize decision‐making by a government entity whose objective is to minimize region‐wide hurricane losses. We examine the effect of different policies on homeowner mitigation, insurance take‐up rate, insurer profit, and solvency in a case study using data for eastern North Carolina. Our findings indicate that an approach that coordinates insurance, retrofits, and acquisition of high‐risk properties effectively reduces total (uninsured and insured) losses.
Stopping Time Detection of Wood Panel Compression: A Functional Time-Series Approach
Authors: Shang Han Lin , Cao Jiguo , Sang Peijun 
Published: June 2022

AbstractWe consider determining the optimal stopping time for the glue curing of wood panels in an automatic process environment. Using the near-infrared spectroscopy technology to monitor the manufacturing process ensures substantial savings in energy and time. We collect a time-series of curves from a near-infrared spectrum probe consisting of 72 spectra and aim to detect an optimal stopping time. We propose an estimation procedure to determine the optimal stopping time of wood panel compression and the estimation uncertainty associated with the estimated stopping time. Our method first divides the entire data set into a training sample and a testing sample, then iteratively computes integrated squared forecast errors based on the testing sample. We then apply a structural break detection method with one breakpoint to determine an estimated optimal stopping time from a univariate time-series of the integrated squared forecast errors. We also investigate the finite sample performance of the proposed method via a series of simulation studies.
HLA graph, a free and ready‐to‐use bioinformatics tool to explore anti‐HLA eplets reactivity pattern
Authors: Usureau Cédric , Jacob Valentine , Dubois Valérie , Masson Dominique , Jollet Isabelle , Desoutter Judith , Taupin Jean‐Luc , Guillaume Nicolas 
Published: June 2022

IntroductionHLA antigens are highly polymorphic, and their immunogenicity is dependent on the configurations of polymorphic amino acids. Monitoring anti‐HLA immunization is essential in organ transplantation, as antibodies directed against HLA molecules are a major cause of rejection. Anti‐HLA antibodies are not specific for HLA antigens, but recognize B‐cell epitopes present on HLA molecules.MethodsTo better understand antibody reactivity patterns, we calculated the Spearman correlation of the mean fluorescence intensity (MFI) of anti‐HLA antibodies identified by a single‐antigen assay performed using a Luminex® immunobeads assay on a large number of samples. Then, we built a computer tool analyzing antibody reactivity patterns with an accessibility by a web browser linked to the International Epitope Registry. We also extended our model to Onelambda® and Lifecodes® single‐antigen class I and class II assays.Results and DiscussionThe resulting MFI correlations reflect HLA antibody cross‐reactivity and eplets similarity. We built HLA Graph, a computer tool that analyzes the eplets involved in antibody reactivity profiles. HLA Graph is usable with Onelambda® and Lifecodes® single‐antigen class I and class II assays. The interpretation of reactivity against alleles not tested by the antibody assays and against the alpha and beta chains of HLA‐DQ and HLA‐DP loci were also developed.ConclusionHLA Graph is a free and ready‐to‐use bioinformatics tool that can be used by all laboratories performing anti‐HLA antibody identification by immunobead assay.
Experimental Study of Various Low-Friction Coatings for High-Temperature Gas Foil Bearings Under Cold-Start Conditions
Authors: Bagiński Paweł , Żywica Grzegorz 
Published: June 2022

Abstract
This article presents the experimental research carried out on five different materials with which the top foils have been coated. A foil bearing with these foils was tested under different load conditions. The key operating parameters were determined, such as the moment of friction during the run-up and run-down tests as well as the temperature of the top foil. The AS20 coating, like the TiAlN coating, was intact (with the exception of several places where it was worn and where the Inconel sheet was visible) and was suitable for further use. The WC/C coating was damaged in many places, which shows that this type of coating cannot be used in combination with a journal coated with chromium oxide. The foil coated with MoS2/C had many areas where the coating was worn and also many areas where it was erased completely, so this type of coating was not durable. The use of a combination of TiAlN and MoS2/C coatings resulted in minor wear of the outer coating (made of MoS2/C) and the appearance of the inner coating, which is more resistant to abrasion. The tested materials will be used in the future to build a foil bearing resistant to operation at elevated temperatures in a gas microturbine.
Robust Design Optimization of Component Parameters for DMDEB Powertrain System Based on Taguchi Method
Authors: Shangguan Jinyong , Yue Ming , Fang Chao , Qi Huanyu 
Published: June 2022

Abstract
The selection of component parameters plays an important role in the energy optimization of dual-motor drive electric buses (DMDEBs). To design a set of parameters that can be robust to different road slopes, passenger masses, and bus routes, a Taguchi-based robust design optimization method is proposed in this paper for DMDEBs. First, the dynamic programming (DP) is designed as a part of the Taguchi method to explore the optimal solution (electricity consumption) corresponding to each set of component parameters. Then, by taking the optimal electricity consumption obtained by DP as the response, the Taguchi method is utilized to find the robust component parameters that are insensitive to the noise factors. To evaluate the robustness and reliability of the designed component parameters, a six sigma analysis based on Monte Carlo sampling is employed considering three kinds of stochastic disturbances. Finally, simulation results demonstrate that the proposed robust design optimization method is effective and the designed component parameters have better robustness than the initial component parameters.
Computational Fluid Dynamics Analysis of the Influence of Gas Content on the Rotordynamic Force Coefficients for a Circumferentially Grooved Annular Seal for Multiple Phase Pumps
Authors: Wu Tingcheng , Andrés Luis San , Lu Xueliang 
Published: June 2022

Abstract
Pumping efficiency and rotordynamic stability are paramount to subsea multiphase pump operation since, during the life of a well, the process fluid transitions from a pure liquid to a mixture of gas in the liquid to just gas. Circumferentially grooved seals commonly serve as balance pistons in pumps while also restricting secondary flow. Prior experimental results obtained with a grooved seal operating with a mixture of air and mineral oil show the seal rotordynamic force coefficients vary significantly with the gas volume fraction (GVF). This paper, complementing an exhaustive experimental program, presents a computational fluid dynamics (CFD) analysis to predict the leakage and dynamic force coefficients of a circumferentially grooved seal supplied with air in an oil mixture with a GVF varying from 0 to 0.7. The test seal has 14 grooves, an overall axial length of 43.6 mm, and radial clearance of 0.211 mm. The 127 mm diameter rotor spins at constant angular speed (Ω = 3500 rpm). The mixture enters the seal at a supply pressure (Pin) of 2.9 bar(a), and the seal exit pressure (Pout) is 1 bar(a). The CFD two-phase flow simulations utilize the Euler–Euler multiphase model to predict the mass flowrate and the pressure field as a function of the operating conditions. Using a multi-frequency shaft orbit motion method, the CFD simulations deliver the variations of reaction force on the rotor with respect to the excitation frequency. For a pure liquid condition (GVF = 0), both the CFD and experimental results produce constant stiffness, damping, and added mass coefficients. The experimental and CFD results demonstrate the seal rotordynamic force coefficients are quite sensitive to the GVF. When introducing a small amount of air into the oil (GVF = 0.1), the direct damping coefficient increases by approximately 10%. For operation with a mixture with inlet GVF &gt; 0.1, the cross-coupled stiffness coefficients develop strong frequency-dependent characteristics. In contrast, the direct damping coefficient has a negligible variation with excitation frequency. The CFD predictions, as well as the experimental results, evidence that air injection in a liquid stream can significantly change the seal rotordynamic characteristics, and thus can affect the rotordynamic stability of a pump. An accurate CFD analysis provides engineers to design reliable grooved seals operating under two-phase flow conditions.
Synthesis and Structures of Copper and Thallium(I) Coordination Compounds [Cu2[B10H10]]n and Tl2[B10H10] with the closo-Decaborate Anion
Authors: Avdeeva V. V. , Kubasov A. S. , Korolenko S. E. , Goeva L. V. , Malinina E. A. , Kuznetsov N. T. 
Published: June 2022

Abstract
Solvent-free copper(I) and thallium(I) compounds of the general formula [M2[B10H10]] have been synthesized. The compounds have been identified by IR spectroscopy and X-ray diffraction. According to X-ray diffraction data, the structures of both compounds are three-dimensional frameworks. In copper(I) complex [Cu2[B10H10]]n, the formation of three-center M–H–B bonds is observed. In thallium(I) compound Tl2[B10H10], the bond between cations and anions is ionic, which is confirmed by IR spectroscopy data. The Hirschfeld surface analysis of the boron cluster anion was performed for both compounds to identify and analyze intramolecular interactions.
Maternal mental health and substance use disorders in sudden unexpected death in infancy using routinely collected health data in New Zealand, 2000–2016
Authors: Mitchell Edwin A , Zhang Doney , Thompson John M D , Liu Chris , Leversha Alison , Milne Barry J 
Published: June 2022

BackgroundMortality from sudden unexpected death in infancy (SUDI) has declined dramatically since the ‘Back to Sleep’ campaign. Deaths now are more prevalent in those with socioeconomic disadvantage. The investigation of SUDI frequently identifies parents that have mental health or drug, alcohol and addiction problems.AimsTo estimate the prevalence of maternal mental health and substance use disorders and assess the magnitude of their risk for SUDI.MethodsWe conducted a population-based cohort study using data from the Integrated Data Infrastructure (IDI), a large research database containing linked data from a range of government agencies. The study population was all live births and their mothers in New Zealand from 2000 to 2016. The exposures of interest were maternal mental health problems and maternal substance use disorders in the year prior to the birth. The outcome was deaths from SUDI.ResultsThe total population was 1086 504 live births and of these 1078 811 (99.3%) were able to be linked to other data sets within the IDI. The prevalence of maternal mental health problems in the total population was 5.2% and substance use disorder was 0.7%. There were 42 deaths from SUDI (0.75/1000) that were exposed to maternal mental illness and 864 deaths (0.84/1000) that were not exposed (adjusted relative risk (aRR)=1.23, 95% CI 0.90 to 1.68). There were 21 deaths from SUDI (2.67/1000) that were exposed to maternal substance use disorders and 885 (0.83/1000) that were not exposed (aRR=1.82, 95% CI 1.17 to 2.83).ConclusionsMaternal substance use disorders, but not maternal mental health problems, in the year prior to the child’s birth was associated with an increased risk of SUDI. However, the numbers that are affected are small and the effect size moderate. This group of women should receive additional SUDI prevention services and Safe Sleep advice.
Political environment and mortality rates in the United States, 2001-19: population based cross sectional analysis
Authors: Warraich Haider J , Kumar Pankaj , Nasir Khurram , Joynt Maddox Karen E , Wadhera Rishi K 
Published: June 2022

AbstractObjectiveTo assess recent trends in age adjusted mortality rates (AAMRs) in the United States based on county level presidential voting patterns.DesignCross sectional study.SettingUSA, 2001-19.Participants99.8% of the US population.Main outcome measuresAAMR per 100 000 population and average annual percentage change (APC).MethodsThe Centers for Disease Control and Prevention WONDER database was linked to county level data on US presidential elections. County political environment was classified as either Democratic or Republican for the four years that followed a November presidential election. Additional sensitivity analyses analyzed AAMR trends for counties that voted only for one party throughout the study, and county level gubernatorial election results and state level AAMR trends. Joinpoint analysis was used to assess for an inflection point in APC trends.ResultsThe study period covered five presidential elections from 2000 to 2019. From 2001 to 2019, the AAMR per 100 000 population decreased by 22% in Democratic counties, from 850.3 to 664.0 (average APC −1.4%, 95% confidence interval −1.5% to −1.2%), but by only 11% in Republican counties, from 867.0 to 771.1 (average APC −0.7%, −0.9% to −0.5%). The gap in AAMR between Democratic and Republican counties therefore widened from 16.7 (95% confidence interval 16.6 to 16.8) to 107.1 (106.5 to 107.7). Statistically significant inflection points in APC occurred for Democratic counties between periods 2001-09 (APC −2.1%, −2.3% to −1.9%) and 2009-19 (APC −0.8%, −1.0% to −0.6%). For Republican counties between 2001 and 2008 the APC was −1.4% (−1.8% to −1.0%), slowing to near zero between 2008 and 2019 (APC −0.2%, −0.4% to 0.0%). Male and female residents of Democratic counties experienced both lower AAMR and twice the relative decrease in AAMR than did those in Republican counties. Black Americans experienced largely similar improvement in AAMR in both Democratic and Republican counties. However, the AAMR gap between white residents in Democratic versus Republican counties increased fourfold, from 24.7 (95% confidence interval 24.6 to 24.8) to 101.3 (101.0 to 101.6). Rural Republican counties experienced the highest AAMR and the least improvement. All trends were similar when comparing counties that did not switch political environment throughout the period and when gubernatorial election results were used. The greatest contributors to the widening AAMR gap between Republican and Democratic counties were heart disease (difference in AAMRs 27.6), cancer (17.3), and chronic lower respiratory tract diseases (8.3), followed by unintentional injuries (3.3) and suicide (3.0).ConclusionThe mortality gap in Republican voting counties compared with Democratic voting counties has grown over time, especially for white populations, and that gap began to widen after 2008.
Low back pain and associated factors among obstetrics care providers in public hospitals of Amhara Regional State, Ethiopia: a cross-sectional study
Authors: Zewudie Bitew Tefera , Temere Bogale Chekole , Eniyew Muche Argaw , Mesfin Yibeltal , Tenaw Shegaw Geze 
Published: June 2022

ObjectivesAlthough the study of low back pain (LBP) among healthcare workers in Ethiopia is becoming common, it mainly focused on nurses leaving obstetrics care providers aside. The objective of this study was to assess the prevalence and associated factors of LBP among obstetrics care providers in public hospitals in Amhara Regional State, Ethiopia.DesignAn institution-based cross-sectional study.SettingsThe study settings were nine public hospitals in Amhara Region.ParticipantsRandomly selected 416 obstetrics care providers working in public hospitals in Amhara Region, Ethiopia.OutcomesThe outcomes of this study were the prevalence of LBP in the last 12 months among obstetrics care providers and its associated factors.ResultsOverall, the prevalence of LBP was 65.6% (95% CI 61.5% to 70.2%) among obstetrics care providers in the last 12 months.Female gender (AOR 2.33, 95% CI 1.344 to 4.038), not having regular physical exercise habits (AOR 8.26, 95% CI 4.36 to 15.66), job stress (AOR 2.21, 95% CI 1.24 to 3.92), standing longer while doing procedures (AOR 2.04, 95% CI 1.14 to 3.66) and working more than 40 hours a week (AOR 2.20, 95% CI 1.09 to 4.45) were significantly associated with LBP.ConclusionAbout two-thirds of obstetrics care providers working in public hospitals in the Amhara region reported LBP. The prevalence of LBP was higher among those who did not have regular physical exercise habits, had job stress, stood longer than 1 hour while doing procedures, worked more than 40 hours a week and female obstetrics care providers. Providing resting periods, decreasing the working hours of obstetrics care providers in a week, and counselling on the importance of doing regular physical exercise help to reduce the prevalence of LBP.