bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safely catching aerial micro-robots in mid-air using an open-source aerial robot with soft gripper
Authors: Liu Zhichao , Mucchiani Caio , Ye Keran , Karydis Konstantinos 
Published: November 2022

This work focuses on catching safely an aerial micro-robot in mid-air using another aerial robot that is equipped with a universal soft gripper. To avoid aerodynamic disturbances such as downwash, that would push the target robot away, we follow a horizontal grasping approach. To this end, the article introduces a gripper design based on soft actuators that can stay horizontally straight with a single fixture and maintain sufficiently compliance in order to bend when air pressure is applied. Further, we develop the Soft Aerial Gripper (SoAG), an open-source aerial robot equipped with the developed soft end-effector and that features an onboard pneumatic regulation system. Experimental results show that the developed low-cost soft gripper has fast opening and closing responses despite being powered by lightweight air pumps, responses that are comparable to those of a commercially available end-effector tested we test against. Static grasping tests study the soft gripper’s robustness in capturing aerial micro-robots under aerodynamic disturbances. We experimentally demonstrated the feasibility of using the SoAG robot to catch a hovering micro-robot with or without propeller guards. The feasibility of dynamic catching is also shown by capturing a moving aerial micro-robot with a velocity of 0.2 m/s. The free flight performance of the SoAG robot is studied against a conventional quadrotor and in different gripper and payload status.
Dental caries and associated factors among diabetic and nondiabetic adult patients attending Bichena Primary Hospital’s Outpatient Department
Authors: Shiferaw Anley , Alem Girma , Tsehay Mekonnen , Kibret Getiye Dejenu 
Published: November 2022

PurposeDental caries is a significant public health issue affecting both the diabetic and nondiabetic populations. However, the problem and associated factors of dental caries among diabetics and nondiabetics patients are not well-known in Ethiopia. This study aims to compare the prevalence of dental caries and associated factors among diabetic and nondiabetic patients at the Outpatient Department of Bichena Primary Hospital in Northwest, Ethiopia.MethodsInstitutional based, comparative cross-sectional study was conducted from October 7 to December 6, 2019, among 200 diabetes and 400 nondiabetic adult patients. A consecutive sampling technique was implemented to recruit study participants. Data were collected by a pretested structured questionnaire and analysis was performed in Statistical Package for Social Science version 20. Bivariable and multivariable logistic regressions were employed and variables with a p-value &lt; 0.05 were declared statistically significant.ResultsA total of 582 patients were involved in the study with a response rate of 97.0%. The prevalence of dental caries was 67.9% [95% confidence interval (CI): 63.2%–72.8%] and 79.6% (95% CI: 74.0%–85.70%) in nondiabetic and diabetic group, respectively. Females gender [adjusted odds ratio (AOR) = 1.79, 95% CI: 1.15–2.77], poor oral hygiene (AOR = 2.95, 95% CI: 1.71–5.11), lack of regular teeth cleaning habits (AOR = 3.26, 95% CI: 2.13–4.97), feeling dry mouth (AOR = 2.31, 95% CI: 1.11–4.81), sugared tea drinking (AOR = 2.00, 95% CI: 1.18–3.38), inadequate oral health knowledge (AOR = 3.51, 95% CI: 2.19–5.62), and khat chewing (AOR = 2.14, 95% CI: 1.24–3.71) were significantly associated factors with high prevalence of dental caries.ConclusionThe prevalence of caries was significantly higher among diabetics than nondiabetics. Oral health education with preventive measures such as improving teeth cleaning practice, reducing sugary foods and drinks intake, and improving oral hygiene practice of patients should be mainstreamed along with diabetic follow-up care.
Application of protective weight-bearing in osteonecrosis of the femoral head: A systematic review and meta-analysis of randomized controlled trials and observational studies
Authors: Chen Wen-huan , Guo Wen-xuan , Li Jian-xiong , Wei Qiu-shi , Li Zi-qi , He Wei 
Published: November 2022

BackgroundThe aim of this systematic review and meta-analysis was to estimate the efficacy and prognostic value of protective weight-bearing for ONFH.MethodsThe authors searched the PubMed, EMBASE and Cochrane Library databases, up to February 25, 2022. RCTs and observational studies on conservative treatment, including the use of crutches, for skeletally mature patients with ONFH and written in English were included. Outcomes were the total hip arthroplasty (THA) rate, collapse rate, Hip Harris score (HHS) and visual analog scale (VAS) score. Cochrane Review Manager Software 5.4 and Stata 15.1 were used to perform the statistical analyses.ResultsA total of 14 studies involving 813 patients (1,025 hips) were included in this meta-analysis. The results showed that the THA rate, collapse rate, HHS and VAS scores in the protective weight-bearing group were not significantly different from those in the surgical group. In the protective weight-bearing group, the results showed that the THA rate was 40%, 8% in ARCO stage II, 37% in ARCO stage III, and the collapse rate was 46%. The mean HHS and VAS score was 80.86 and 1.00, respectively. The HHS score at the 3-, 6-, 12-, and 24-month follow-up was 79.93, 83.94, 85.94, and 96.09 points, respectively, whereas the VAS score at the 6- and 12-month follow-up was 2.20 and 1.29, respectively.ConclusionProtective weight bearing could achieve satisfactory results in terms of THA rate, collapse rate, HHS and VAS scores. Protective weight-bearing allows most precollapse patients to preserve the hip but also allows postcollapse patients to delay THA or hip-preserving surgery. The effects and prognosis of protective weight-bearing in the short or mid-term are noninferior to surgical hip preservation and are a viable alternative option for osteonecrosis of the femoral head.
A novel knotless hand-sewn end-to-end anastomosis using V-loc barbed suture vs. stapled anastomosis in laparoscopic left colonic surgery: A propensity scoring match analysis
Authors: Xu Shining , Zhao Xuan , He Zirui , Yang Xiao , Ma Junjun , Dong Feng , Zang Lu , Fingerhut Abe , Zhang Luyang , Zheng Minhua 
Published: November 2022

BackgroundLaparoscopic colectomy is widely practiced for colon cancer, but many variations exist for anastomosis after laparoscopic colon cancer radical resection.MethodWe retrospectively analyzed 226 patients who underwent laparoscopic-assisted radical resection for left colon cancer with knotless hand-sewn end-to-end anastomosis (KHEA) technique with barbed V-loc™ suture material and compared perioperative outcomes, safety, and efficacy to those undergoing stapled anastomosis from 2010 to 2021.ResultsAfter the 1:2 propensity score matching, 123 participants with similar preoperative characteristics (age, body mass index, TNM stage, and tumor location) were enrolled in the study: 41 in the KHEA and 82 in the stapler group. Statistically significant differences were found in time to accomplish the anastomosis (mean 7.9 vs. 11.9 min, p &lt; 0.001) and hospital costs (mean 46,569.71 vs. 50,915.35 CNY, p &lt; 0.05) that differed between the KHEA and stapler group, respectively. No statistically significant difference was found in the mean delay to bowel function recovery (2.6 vs. 2.7 days, p = 0.466), duration of hospital stay (8.6 vs. 7.9 days, p = 0.407), or rate of postoperative complications (14.6% vs. 11.0%, p = 0.563). Anastomotic leakage occurred in 11 patients: 5 (12.2%) vs. 6 (7.3%) (p &gt; 0.05) in the KHEA and stapler group, respectively.ConclusionKHEA is feasible and safe for anastomosis after laparoscopic left hemicolectomy. The KHEA technique could reduce operation time and hospital costs with complication rates comparable to stapling.
The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protection
Authors: Beukenhorst Anna L. , Frallicciardi Jacopo , Koch Clarissa M. , Klap Jaco M. , Phillips Angela , Desai Michael M. , Wichapong Kanin , Nicolaes Gerry A. F. , Koudstaal Wouter , Alter Galit , Goudsmit Jaap 
Published: November 2022

Human monoclonal antibodies (hmAbs) that protect against all influenza A and B strains are considered the road to universal influenza vaccines. Based on publicly-available data, we analyze the mechanistic and structural basis of pan-influenza protection by CR9114, a hemagglutinin (HA) stem-reactive antibody that protects against influenza subtypes from groups A1, A2, and B. The mechanistic basis of CR9114’s universal protection is not limited to in vitro neutralization, as CR9114 also protects in vivo from strains that escape its neutralizing activity: some H2 strains and influenza B. Fusion inhibition, viral egress inhibition, and activation of Fc-mediated effector functions are key contributors to CR9114’s universal protection. A comparative analysis of paratopes – between CR9114 (pan-influenza protection) and structurally similar VH1-69 hmAb CR6261 (influenza A1 protection) – pinpoints the structural basis of pan-influenza protection. CR9114’s heterosubtypic binding is conferred by its ability to bind HA with multiple domains: three HCDR loops and FR3. In contrast to other VH1-69 hmAbs, CR9114 uses a long and polar side chain of tyrosine (Y) residues on its HCDR3 for crucial H-bonds with H3, H5, and B HA. The recognition of a highly conserved epitope by CR9114 results in a high genetic barrier for escape by influenza strains. The nested, hierarchical structure of the mutations between the germline ancestor and CR9114 demonstrates that it is the result of a narrow evolutionary pathway within the B cell population. This rare evolutionary pathway indicates an immuno-recessive epitope and limited opportunity for vaccines to induce a polyclonal CR9114-like response.
Identification of the Transcription Factors RAP2-13 Activating the Expression of CsBAK1 in Citrus Defence Response to Xanthomonas citri subsp. citri
Authors: Wu Qi , Zhao Mingming , Li Yi , Li Dazhi , Ma Xianfeng , Deng Ziniu 
Published: November 2022

Citrus canker is a quarantined disease caused by the bacterial plant pathogen Xanthomonas citri subsp. citri (Xcc), which causes persistent surface damage, leaf and fruit drop, and tree decline in citrus plants. The citrus cultivar Citron C-05 (Citrus medica L.) is a disease-resistant genotype identified after years of screening at the National Center for Citrus Improvement (Changsha), which displays allergic, necrotic, and disease-resistant responses to Xcc. In this study, the BAK1 gene was identified in this cultivar to be a disease resistance gene involved in plant-microbe interaction between citrus and Xcc. Functional investigations of this gene revealed that both CsBAK1 (C. sinensis BAK1) or CmBAK1(C. medica BAK1) could inhibit the growth of Xcc to some extent when transiently expressed in the susceptible ‘Bingtang’ genotype of sweet orange. Critical regions of the CmBAK1 promoter sequence were identified by creating downstream deletions and exposing mutants to Xcc to determine effects on the resistance phenotype; a 426 bp region (−2000~–1574) was identified as a key functional region responsible for eliciting the hypersensitive response in plants. Through screening arrayed Citron C-05 cDNA libraries by yeast one-hybrid assays, a basic APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factor of CmRAP2-13 that binds directly to the 426 bp key sequence and activates expression of CmBAK1 was identified. Moreover, transcriptional analysis revealed an obvious increase in transcript levels of CsRAP2-13 in Citron C-05, American citron, and Finger citron. In this study, we present the identification of transcriptional activators that are found to interact with BAK1 proteins in response to Xcc. These results reveal a coordinated regulatory mechanism of RAP2-13, which may be involved in defence responses through the regulation of BAK1.
European and Mediterranean Myzocallidini Aphid Species: DNA Barcoding and Remarks on Ecology with Taxonomic Modifications in An Integrated Framework
Authors: Massimino Cocuzza Giuseppe Eros , Magoga Giulia , Montagna Matteo , Nieto Nafría Juan Manuel , Barbagallo Sebastiano 
Published: November 2022

The genus Myzocallis Passerini (Hemiptera, Aphididae, Calaphidinae, Myzocallidini) is a rather primitive group of aphids currently comprising 45 species and 3 subspecies, subdivided into ten subgenera, three of them having a West Palaearctic distribution. The majority of the species inhabit Fagales plants and some of them are considered pests. Despite their ecological interest and the presence of some taxonomic controversies, there are only a few molecular studies on the group. Here, the main aims were to develop a DNA barcodes library for the molecular identification of West Palaearctic Myzocallis species, to evaluate the congruence among their morphological, ecological and DNA-based delimitation, and verify the congruence of the subgeneric subdivision presently adopted by comparing the results with those obtained for other Panaphidini species. These study findings indicate that Myzocallis (Agrioaphis) leclanti, originally described as a subspecies of M. (A.) castanicola and M. (M.) schreiberi, considered as a subspecies of M. (M.) boerneri, should be regarded at a rank of full species, and the subgenera Agrioaphis, Lineomyzocallis, Neomyzocallis, Pasekia were elevated to the rank of genus, while Myzocallis remain as such.
La participación como un acto educador y constructor de la Ciudad Educadora
Authors: Rodríguez Rodríguez Jahir 
Published: November 2022

El documento se desarrolla en cuatro capítulos los cuales centran su reflexión en las relaciones que se establecen entre la escuela y la ciudad, en donde la participación, el dialogo y la democracia se constituyen en los elementos que articulan la nueva ciudadanía.
En palabras iniciales, se presenta un debate entorno al concepto de Educación pensado y reflexionado desde la filosofa alemana, Hannah Arendt; en el primer capitulo, la ciudad como espacio educador, se plantean unos argumentos a favor de la tesis de que la ciudad es esencialmente un espacio donde se educa, construye la ciudadanía, y es la ciudad la que tiene que jugar un papel en el respeto y la construcción de las identidades múltiples y sus valores que reclama la época contemporánea; en el segundo capitulo, el currículum de la ciudad, recupera la idea que existe a lo largo de los espacios construidos socialmente por el hombre como ser histórico, otra educación, que se vive y disfruta en cada rincón de la ciudad, como un currículum oculto que se habre a la vida de la ciudad en cada momento que se busca su quehacer pedagógico; en el tercer capitulo, la participación como proceso educativo, se reflexiona sobre el papel político de la participación y esta como contribuye a una democracia más abierta, donde la participación debe estar destinada no solo a consolidar la democracia como régimen político, sino a potenciar y fortalecer el desarrollo de la democracia como un estilo de vida que favorece nuestra convivencia; en el capitulo cuarto, se reseña una experiencia de participación ciudadana desarrollada en nuestra ciudad, en el proceso de presupuesto participativo, como un proceso de participación ciudadana, donde la participación se revitaliza cuando los ciudadanos nos convencemos de que tenemos una actitud que asumir y que hacer respetar; y finalmente se deja consignado un sueño de escuela y un propósito de Ciudad Educadora, a manera de reflexión.
La participación de las mujeres en el proceso de formación del Estado Nacional en Argentina de finales del siglo XIX. Reflexiones desde una perspectiva de género
Authors: Anzorena Claudia 
Published: November 2022

En este artículo propongo reflexionar, desde un puno de vista de género, en torno a la participación de las mujeres en la formación del Estado Nación en Argentina. En Argentina el proyecto de masificación de la educación moralizadora y civilizadora, que acompañó la creación de la Nación en la segunda mitad del Siglo XIX, se dio simultáneamente con la feminización de la docencia, la generalización de la escuela mixta y la propuesta de un currículo único. Este proceso tuvo como protagonistas escasamente reconocidas a las mujeres, porque fueron especialmente “convocadas” para la creación y difusión de valores, conocimientos y símbolos reforzadores de sentimientos de nacionalidad, no sólo por su papel dentro de la familia sino especialmente por su “misión” en el proyecto educativo nacional.
La participación de las mujeres en dicho proyecto tiene como consecuencia que hoy se considera, falsamente, saldada la deuda educativa con las mujeres y garantizada la igualdad de oportunidades.
Teorias-guia educacionais da produção dos materiais didáticos para a transversalidade curricular do meio ambiente do MMA
Authors: Hiroo Saito Carlos , Da Purificação de Bastos Fabio , Abegg Ilse 
Published: November 2022

O objetivo do presente trabalho é descrever e problematizar conceitos-chave da concepção educacional que guiaram a produção de um conjunto articulado de material didático impresso e digital (composto de portifólios com fotos e textos, um livro do professor e um jogo educativo de tabuleiro) produzido para o Projeto de Conservação e Utilização Sustentável da Diversidade Biológica Brasileira (PROBIO), do Ministério do Meio Ambiente no ano acadêmico de 2005-2006. O conjunto do material didático (disponível em http://www.unb.br/ib/ecl/eaprobio) versa sobre a biodiversidade brasileira, que integra os biomas brasileiros, as espécies da fauna brasileira ameaçadas de extinção (constantes da lista oficial), a problemática da fragmentação de ecossistemas e das espécies exóticas invasoras e a importância das Unidades de Conservação da Natureza, no contexto dos compromissos assumidos pelo governo brasileiro junto à Convenção sobre Diversidade Biológica (CDB), em 1992, e a posterior instituição da Política Nacional da Biodiversidade. Pretende-se conceder especial atenção ao escopo teórico-metodológico da produção do elemento central e articulador desse material didático que são os pares de portifólios compostos por problematizações em torno de conflitos socioambientais reais e ações positivas implementadas, geradoras e sustentadoras do diálogo com os alunos nas atividades escolares transversais de meio ambiente, buscando ainda fortalecer uma cultura de participação socioeducacional, e a promoção ou fortalecimento dos movimentos sociais organizados. Explicita-se, do ponto de vista educacional, o esforço para integrar as idéias de investigação-ação, empowerment e diálogo-problematizador, de forma a produzir um material nas perspectivas critica e emancipatória, de acordo com a Política Nacional de Educação Ambiental.
AKUNTANSI SOSIAL: PENGAKUAN, PENGUKURAN, DAN PELAPORAN LAPORAN KEUANGAN EKSTERNALITAS PADA PERUSAHAAN PERTAMBANGAN DI INDONESIA
Authors: Siregar Inova Fitri , Rasyad Rinayanti , Onasis Dini 
Published: November 2022

Penelitian ini bertujuan untuk melihat dampak sosial dan lingkungan dari perusahaan pertambangan dalam hal manfaat sosial atau biaya sosial dan bagaimana mengukur, dan melaporkan secara finansial. Metode dalam penelitian ini menggunakan purposive sampling, dimana penentuan sampel menggunakan beberapa kriteria yaitu perusahaan yang masuk dalam sustainability report, Kemudian perusahaan yang memiliki atau mengeluarkan biaya lingkungan berupa biaya program bina lingkungan, terdapat adalah 5 perusahaan BUMN di bidang pertambangan Industri Pertambangan Indonesia yang memenuhi kriteria sampel. Sektor Mind.Id dipilih, diharapkan perusahaan dapat menjadi model aturan bagi perusahaan lain untuk mengungkapkan manfaat sosial dan biaya sosial bagi perusahaannya. Hasil dari penelitian ini adalah terdapat 5 perusahaan yaitu PT. Aneka Tambang, Tbk. PT. Bukit Asam, Tbk. PT. Freeport, Tbk. PT. Inalum, Tbk dan PT. Timah, Tbk yang secara global telah membuat dan mengukur hingga pelaporan keberlanjutan, PT. Antam menyajikan informasi biaya lingkungan secara sistematis dan dalam bentuk laporan yang lengkap, sedangkan PT. Freeport, Tbk mengungkapkan laporan keberlanjutan dalam bentuk naratif tanpa mengungkapkan laporan biaya lingkungan sehingga tidak terlihat apakah biaya yang dikeluarkan masuk dalam kategori manfaat sosial atau biaya sosial.
Kata Kunci : Triple Bottom Line, Akuntansi sosial, ekternalitas

ABSTRAK
Penelitian ini bertujuan untuk melihat dampak sosial dan lingkungan dari perusahaan pertambangan dilihat dari manfaat sosial atau biaya sosial dan bagaimana pengukuran, dan pelaporan keuangan. Metode dalam penelitian ini adalah menggunakan purposive sampling, di mana penetrasi sampel menggunakan beberapa kriteria yaitu perusahaan yang masuk dalam laporan, kemudian perusahaan yang mengeluarkan atau mengeluarkan biaya lingkungan dalam bentuk biaya program, terdapat 5 perusaahaan BUMN Sektor Pertambangan Industri Indonesia yang memenuhi kriteria sampel. Dipilih sector Mind.Id diharapkan adalah perusahaan tersebut dapat menjadi model aturan bagi perusahaan lainnya untuk mengungkapkan manfaat sosial dan biaya sosial bagi perusahaannya Hasil penelitian ini adalah terdapat 5 perusahaan yaitu PT.Aneka Tambang,Tbk . PT.Bukit Asam,Tbk. PT.Freeport,Tbk. PT.Inalum,Tbk dan PT.Timah,Tbk yang secara global sudah membuat dan mengukur pengungkapan, PT.Antam menyajikan informasi biaya secara sistematis dan dalam bentuk pelaporan lengkap sedangkan PT.Freeport,Tbk mengungkapkan laporan dengan bentuk saja tanpa mengungkapkan laporan biaya lingkungan sehingga tidak terlihat apakah biaya yang dikeluarkan masuk dalam kategori manfaat sosial atau biaya sosial.
TANGGUNG JAWAB HUKUM PELAKU USAHA FARMASI TERHADAP IZIN EDAR OBAT
Authors: Nugroho Leonardo Cahyo 
Published: November 2022

<p>Setiap peredaran obat, bahan obat, obat tradisional, dan kosmetika di Indonesia wajib memperoleh izin edar sebelum obat tersebut dapat didistribusikan. Namun kenyataannya masih banyak obat beredar tanpa izin edar. Oleh karena itu, penelitian ini berjudul Tanggung Jawab Hukum Pelaku Usaha Farmasi Terhadap Izin Edar Obat Dalam Upaya Penyembuhan Penyakit. Perumusan Masalah: Bagaimana tanggung jawab hukum pelaku usaha farmasi terhadap izin edar obat dalam upaya penyembuhan penyakit? Bagaimana hambatan-hambatan dan solusinya tanggung jawab hukum pelaku usaha farmasi terhadap izin edar obat dalam upaya penyembuhan penyakit di Kabupaten Semarang? Tujuan Penelitian : Untuk mengetahui dan menganalisis tanggung jawab hukum pelaku usaha farmasi terhadap izin edar obat dalam upaya penyembuhan penyakit. Untuk mengetahui dan menganalisis hambatan-hambatan dan solusinya tanggung jawab hukum pelaku usaha farmasi terhadap izin edar obat dalam upaya penyembuhan penyakit di Kabupaten Semarang. Metode : Pendekatan penelitian ini adalah yuridis normatif, spesifikasi penelitiannya deskriptif analitis, Analisis datanya kualitatif. Hasil : Masih terdapat hambatan dalam pelaksanaan tanggung jawab hukum pelaku usaha farmasi terhadap izin edar obat. Kurangnya pengawasan dan evaluasi dari pemerintah, kemasan obat tanpa izin edar mirip dengan obat berizin edar resmi, harga obat tanpa izin edar lebih murah, kurang pembinaan kepada masyarakat dan pelaku usaha farmasi, penegakan hukum tidak menimbulkan efek jera. Perlu pengawasan dan evaluasi oleh BPOM, pengawasan terhadap penggunaan kemasan yang mirip dengan sistem cek KIK, pembinaan terhadap masyarakat dan pelaku usaha farmasi dijalankan secara berkala, sanksi dapat dipertimbangkan untuk memberikan efek jera. Rekomendasi : pembuatan Peraturan Pemerintah mengenai perluasan kewenangan BPOM dalam hal pengawasan obat, sosialisasi dan penyuluhan mengenai izin edar obat dari pemerintah kepada masyarakat dan pelaku usaha farmasi lewat media dan pertemuan rutin.</p>