bluuebunny/crossref_metadata_2025_split huggingface dataset:
Swimming exercise improves SIRT1, NF-κB, and IL–1β protein levels and pancreatic tissue injury in ovariectomized diabetic rats
Authors: Habibi Parisa , Ahmadiasl Nasser , Nourazarian Alireza , Yousefi Hadi 
Published: April 2022

Abstract

Objectives
In this study, we investigated the beneficial effects of swimming exercise on the SIRT1, NF-κB, IL-1β protein levels, and pancreatic tissue damage in an ovariectomized diabetic rat model based on the anti-inflammatory effect of exercise.

Methods
Forty mature female Wistar rats were purchased and divided into sham (n=10) and OVX (bilateral ovariectomy) (n=30) groups. The ovariectomized rats were divided into 1-OVX, 2-ovariectomized diabetic (OVX.D), 3-OVX.D + exercise (OVX.D. E). After surgical recovery, animals in the diabetic group received a high-fat diet for one month. Swimming exercise (1 h/day) was performed concurrently with the start of the HFD diet for eight weeks. At the end of the high-fat diet, streptozotocin (30 mg/kg) was injected intraperitoneally. At the end of the second month, pancreatic tissue was collected from the animals after deep anesthesia for molecular evaluation and histology by Western blotting and hematoxylin-eosin, respectively.

Results
Swimming exercise significantly decreased inflammatory cytokines and tissue damage, and this decrease in cytokine expression appears to be associated with SIRT1 expression. The increase in SIRT1 by training was associated with decreased NF-κB-p65 and IL–1β expression and preventing tissue damage. Induction of diabetes in the ovariectomized group (OVX.D) resulted in a significant increase in NF-κB-p65 and IL–1β proteins and a decrease in the expression of SIRT1 compared with the sham group. However, swimming training significantly reversed these effects compared with the OVX.D group.

Conclusions
Increased inflammation of β-cells impairs insulin secretion in estrogen insufficiency. Swimming exercise eliminates inflammation in post-menopausal diabetes and supports the potential to prevent pancreatic activity after menopause.
Eine Zeitung in drei Jahrhunderten: Digitalisierung des Darmstädter Tagblatts
Authors: Stegmeier Jörn , Günther Anne-Christine , Hammer Angela , Müller Marcus , Stäcker Thomas 
Published: April 2022

ZusammenfassungAnhand des von der Deutschen Forschungsgemeinschaft (DFG) geförderten Projekts „Digitalisierung des Darmstädter Tagblatts“ (DDAT) wird ein Workflow für die Digitalisierung komplexer und umfangreicher Periodika vorgestellt. Das Projekt wird in Kollaboration zwischen der Universitäts- und Landesbibliothek Darmstadt (ULB) und dem Institut für Sprach- und Literaturwissenschaften der Technischen Universität Darmstadt (TU Darmstadt) durchgeführt. Die Arbeitsschritte umfassen dabei die Bild-Erstellung vom Original, die digitale Weiterverarbeitung bis hin zum maschinenlesbaren Volltext mit linguistischen Basisannotationen, die öffentlich zugängliche Präsentation im Internet und die ausführliche Recherche nach Rechteinhabern einzelner Artikel und Fotografien wie sie in §§ 61 ff. UrhG vorgeschrieben ist („sorgfältige Suche“).
Stabilization of a 1-D transmission problem for the Rayleigh beam and string with localized frictional damping
Authors: Hong Gimyong , Hong Hakho 
Published: April 2022

Abstract
We are concerned with the stability of a 1-D coupled Rayleigh beam-string transmission system.
We obtain the polynomial decay rate

t

-
1

{t^{-1}}

or the exponential decay rate for the given transmission
system whether the frictional damping is only effective in the beam part or the string part, respectively.
This paper generalizes the recent result in
[Y.-F. Li, Z.-J. Han and G.-Q. Xu,
Explicit decay rate for coupled string-beam system with localized frictional damping,
Appl. Math. Lett. 78 2018, 51–58].
The main ingredient of the proof is some careful analysis for the Rayleigh beam and string transmission system.
ProACT in the management of stress urinary incontinence after radical prostatectomy. What happens after 8 years of follow up? monocentric analysis in 42 patients
Authors: Bada Maida , Crocetto Felice , Barone Biagio , Arcaniolo Davide , Rapisarda Sebastiano , Aliberti Antonio , Zeccolini Guglielmo , Celia Antonio 
Published: April 2022

Abstract

Objectives
Stress urinary incontinence is defined by a complaint of any involuntary loss of urine on effort or physical exertion or on sneezing or coughing and represents a major complication after radical prostatectomy. According to surgical technique, incidence of post-prostatectomy incontinence varies from open (7–39.5%), laparoscopic (5–33.3%) or robotic-assisted (4–31%) approaches. The ProACT® device (Uromedica, Inc., MN) is a possible surgical option for the treatment of this condition.

Methods
We retrospectively analyzed surgical records of consecutive patients underwent ProACT® implantation in our department between January 2006 to November 2010. We collected data at 6 and 12 months after surgical approach about the daily pad use, International Prostatic Symptoms Score and its quality of life domain.

Results
42 patients were included in the final analysis. Most patients (92.9%) received minimally invasive surgery for treating prostate cancer. During the follow up after 6 and 12 months, the daily pad, International Prostatic Symptom Score and its quality of life domain significantly improved compared to preoperative outcomes. The logistic regression analysis found that presence of comorbidities was the only predictive factor of low satisfaction rate (PGE-I > 2) in patients who underwent ProACT® implant.

Conclusions
ProACT® implant represents an effective and safe treatment for post-prostatectomy stress urinary incontinence with a high satisfaction degree and a low rate of complications.
Psychological impact of abnormally invasive placenta: an underestimated and hidden morbidity
Authors: Crocetto Felice , Barone Biagio , Bonito Elvira , Maggi Martina , Caputo Vincenzo F. , di Girolamo Antonio , Trama Francesco , di Spiezio Sardo Attilio , Zizolfi Brunella 
Published: April 2022

Abstract

Objectives
To evaluate anxiety and psychological impact of abnormally invasive placenta (AIP) diagnosis during pregnancy.

Methods
A cross-sectional survey study was performed to assess the psychological response of pregnant women with an antenatally AIP diagnosis. The psychological impact was measured through a visual analogue scale (VAS) for anxiety, which ranged from 0 (not at all anxious) to 100 (extremely anxious) and was referred to three questions: (1) How anxious were you the first time they counselled you about AIP?; (2) How anxious were you the day of the planned cesarean delivery in terms of morbidity/mortality?; (3) How anxious were you in terms of future sexual activities?

Results
48 singleton pregnancies that underwent planned cesarean hysterectomy for AIP, met the inclusion criteria and were surveyed for the study. Mean VAS was 41.6 ± 25.6, with 47.9% of women with VAS >50 for question 1 (p=0.015). Mean VAS was 52.9 ± 19.1, with 75.0% of women with VAS >50 for question 2 (p=0.02). Mean VAS was 49.6 ± 20.4, with 83.3% of women with VAS >50 for question 3 (p=0.006).

Conclusions
More than half of pregnant women with an antenatally AIP diagnosis reported a high VAS score regarding anxiety, in particular when morbidity/mortality and long-term consequences on sexual activities were analyzed. Our findings could be used to formulate timely psychological interventions to improve mental health and psychological resilience in women with AIP.
Luke 22:43-44 and the Mormon Jesus: Protestant Past, KJV-Only Present
Authors: Adamson Grant 
Published: April 2022

AbstractJoseph Smith’s interpretation of the Lukan agony in the garden fits with Anglophone Protestant commentaries that were popular during his day. In the Book of Mormon and the Doctrine and Covenants (D&C), the Lukan sweat-like-blood simile is understood as if literal, and Jesus atones in Gethsemane. This was standard fare in exegesis in England and America in the late 1600s, 1700s, and early 1800s. What Smith did was re-cast common interpretation as prophetic and dominical while probably defending the verses, known to be absent from the other Gospels and sometimes suspected to be an interpolation into Luke. On the golden plates of the Book of Mormon, he had an ancient Amerindian prophet-king named Benjamin predict Jesus’ hemorrhage more than a hundred years in advance, and he had none other than the risen Christ verify it in a direct revelation in D&C 19. These references to Luke 22:43–44 in Smith’s extra-biblical writings have created a further apologetic imperative to defend his defense of the Bible, one reason for the LDS Church’s King James Version onlyism.
Corpus literacy empowerment: taking stock of research to look forward for practice
Authors: Li Shuquan , Xu Manfei 
Published: April 2022

Abstract
Over the past decades, corpus linguistics, as an approach to the study of language, has attracted much attention. Applications of its method and various corpus resources have been made in the field of language education as well. However, research in corpus linguistics has not yet been sufficiently converted into a language teacher training perspective especially in the primary and secondary education settings. We therefore call for the development of the corpus literacy of EFL (English as a Foreign Language) teachers as part of their continuous professional development. In support of this call, we examine, from the perspective of a teacher educator, a tentative teacher training model based on the published literature, for student teacher trainees and in-service English practitioners. This paper also offers detailed instructions on how to facilitate the teaching of vocabulary, grammar and discourse with free and user-friendly corpus tools (i.e., SKELL, VersaText and AntConc) in pre-tertiary language classrooms. Some pedagogical implications of the cultivation of EFL teachers’ corpus literacy and major concerns when implementing corpus-based language teaching and learning are also discussed.
A comparative study of perceptions and experiences of online Chinese language learners in China and the United States during the COVID-19 pandemic
Authors: Wang Yanlin , Zhan Hong , Liu Shijuan 
Published: April 2022

Abstract
This study compared the perceptions and experiences of 173 students studying Chinese as a foreign language in universities online during the COVID-19 pandemic in China and the United States. Controlling students’ previous diversity of Chinese course delivery modes across countries and Chinese language levels, three two-way analysis of covariance (ANCOVA) were conducted to compare differences among three dependent variables: 1) satisfaction towards online classes; 2) self-perceived learning effectiveness online versus onsite; and 3) willingness to take a virtual Chinese course in the future. The results did not find statistical significances regarding students’ satisfaction and willingness across countries and language levels. However, the results found students in the United States (US) viewed online classes as significantly less effective than learning in-person, which was different from the views of students in China. The Pearson correlation analysis indicated that there were positive correlations among these three variables. Pearson chi-squared tests found that, significantly, students in the US preferred to take Chinese courses in-person. Pearson’s chi-squared tests on categories formed from the three open-ended questions highlighted the importance of four factors influencing the success of students’ online classes: technology, emotion and motivation, learning productivity, and teaching presence. Pedagogical recommendations are discussed.
Genome-wide expression reveals potential biomarkers in breast cancer bone metastasis
Authors: Singh Yashbir , Subbarao Naidu , Jaimini Abhinav , Hathaway Quincy A. , Kunovac Amina , Erickson Bradley , Swarup Vishnu , Singh Himanshu Narayan 
Published: April 2022

Abstract
Breast cancer metastases are most commonly found in bone, an indication of poor prognosis. Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. We extracted gene expression profiles from mouse macrophages from the GEO dataset, GSE152795 using the GEO2R webtool. The differentially expressed genes (DEGs) were filtered by log2 fold-change with threshold 1.5 (FDR < 0.05). STRING database and Enrichr were used for GO-term analysis, miRNA and TF analysis associated with DEGs. Autodock Vienna was exploited to investigate interaction of anti-cancer drugs, Actinomycin-D and Adriamycin. Sensitivity and specificity of DEGs was assessed using receiver operating characteristic (ROC) analyses. A total of 61 DEGs, included 27 down-regulated and 34 up-regulated, were found to be significant in breast cancer bone metastasis. Major DEGs were associated with lipid metabolism and immunological response of tumor tissue. Crucial DEGs, Bcl3, ADGRG7, FABP4, VCAN, and IRF4 were regulated by miRNAs, miR-497, miR-574, miR-138 and TFs, CCDN1, STAT6, IRF8. Docking analysis showed that these genes possessed strong binding with the drugs. ROC analysis demonstrated Bcl3 is specific to metastasis. DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. Identified genes, miRNAs, and TFs can be possible drug targets that may be used for the therapeutics. However, further experimental validation is necessary.
Hessenberg factorization and firework algorithms for optimized data hiding in digital images
Authors: Gaata Methaq Talib , Younis Muhanad Tahrir , Hasoon Jamal N. , Mostafa Salama A. 
Published: April 2022

Abstract
Data hiding and watermarking are considered one of the most important topics in cyber security. This article proposes an optimized method for embedding a watermark image in a cover medium (color image). First, the color of the image is separated into three components (RGB). Consequently, the discrete wavelet transform is applied to each component to obtain four bands (high–high, high–low, low–high, and low–low), resulting in 12 bands in total. By omitting the low–low band from each component, a new square matrix is formed from the rest bands to be used for the hiding process after adding keys to it. These keys are generated using a hybrid approach, combining two chaotic functions, namely Gaussian and exponential maps. The embedding matrix is divided into square blocks with a specific length, each of which is converted using Hessenberg transform into two matrices, P and H. For each block, a certain location within the H-matrix is used for embedding a secret value; the updated blocks are assembled, and the reverse process is performed. An optimization method is applied, through the application of the firework algorithm, on the set of the initial values that generate keys. Using an optimization procedure to obtain keys requires performing lowest possible change rate in an image and maintain the quality of the image. To analyze and test the efficiency of the proposed method, mean-square error (MSE) and peak signal-to-noise ratio (PSNR) measurements are calculated. Furthermore, the robustness of the watermark is computed by applying several attacks. The experimental results show that the value of the MSE is reduced by about 0.01 while the value of the PSNR is increased by about 1.25 on average. Moreover, the proposed method achieved a high-retrieval rate in comparison with the non-optimization approach.
L’anthroponyme mycénien wa-ra-qi-si-ro (KH X 7)
Authors: Alonso Déniz Alcorac 
Published: April 2022

Abstract
The Mycenaean personal name wa-ra-qi-si-ro has been interpreted as the older variant of wa-ra-pi-si-ro (PY, MY), but this hypothesis comes up against several phonetic problems. This paper proposes two alternative explanations of wa-ra-qi-si-ro: either /Wrakwsilos/, a clipping of *Wrakwsi-lāhos, compound of the root *u̯ergu̯-/*u̯regu̯- “throw” and *lāho- “stone”, or /Wrankwsilos/, a nickname derived from the adjective attested in later Greek ῥαμψός “crooked”.
The Iman touch: a coin legend in Phrygian
Authors: Adiego Ignasi-Xavier , Obrador-Cursach Bartomeu 
Published: April 2022

Abstract
This paper gathers sixteen unlisted coins from several auction catalogues with identical typology: a helmeted head (identified as Athena) on the obverse and a falcon inside a pelleted square on the reverse. Nine of them show the first coin legend in Phrygian identified so far: iman, a personal name. After the analysis of their iconography and legend, a location of the mint in Phrygia during the 5th or 4th century BC is suggested.
The cocrystal 2-(dimethylammonio)-5-nitrobenzoate – 2-(dimethylamino)-5-nitrobenzoic acid, C9H10N2O4
Authors: Cui Jianqiang , Men Jing , Liu Bin 
Published: April 2022

Abstract
C9H10N2O4, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.722(2) Å, b = 10.805(2) Å, c = 10.947(2) Å, α = 67.938(4)°, β = 66.250(4)°, γ = 72.978(4)°, V = 961.8(3) Å3, Z = 4, R

gt
(F) = 0.0421, wR

ref
(F
2) = 0.1339, T = 173 K.
Friedrich Nietzsche: Cheerful Thinker and Writer. A Contribution to the Debate on Nietzsche’s Cheerfulness
Authors: Ansell-Pearson Keith , Serini Lorenzo 
Published: April 2022

AbstractCheerfulness or serenity (Heiterkeit) is one of the most important themes in Nietzsche’s philosophy. Throughout his writings, from first to last, he can be found wrestling with conceptions of cheerfulness and promoting a cheerful mode of philosophizing. Despite the importance and recurrence of the theme of cheerfulness in Nietzsche’s entire œuvre, there have been relatively few studies specifically devoted to it. An important debate on cheerfulness has recently taken place in the literature on Nietzsche between Robert Pippin and Lanier Anderson and Rachel Cristy. Both sides of the debate have explored Nietzsche’s practice of cheerfulness in direct relation to Montaigne. According to Pippin, Nietzsche never succeeds in writing with the kind of cheerfulness of Montaigne. In contrast, Anderson and Cristy have contended that both Nietzsche and Montaigne conceive of cheerfulness as a complex, non-naïve spiritual state or attitude that is to be cultivated through the practice of philosophy as a way of life. According to Anderson and Cristy, this is a deep form of love of life that both Nietzsche and Montaigne practice and perhaps achieve at least in part by and through writing. In this essay, we aim to contribute to this debate by offering a threefold argument. First, we argue that Nietzsche conceives of cheerfulness not only as a psychological ideal, as a desirable state or attitude of the spirit, but also as an aesthetic ideal, as a desirable quality or style of thinking and writing (sections 1–2). Second, we argue that, in addition to Montaigne, Ralph Waldo Emerson is an equally important but neglected influence on Nietzsche’s conception and practice of cheerfulness (section 2). Third, by reconstructing Nietzsche’s self-presentation as a cheerful thinker and writer in the 1886 prefaces and inEcce homo(1888), we conclude that it is possible to argue that starting from his middle writings Nietzsche thinks and writes cheerfully in some of his works, including a number of his most significant texts (section 3).
Die Geburt des Philologen aus dem Geiste der Schopenhauerschen Philosophie. Nietzsches AntrittsvorlesungÜber die Persönlichkeit Homers
Authors: Apollonio Simona 
Published: April 2022

AbstractThe Birth of the Philologist from the Spirit of Schopenhauer’s Philosophy. Nietzsche’s Inaugural LectureOn the Personality of Homer.This essay highlights Schopenhauer’s decisive and unexplored role in Nietzsche’sÜber die Persönlichkeit Homers(1869). Following Schopenhauer’s negative assessment of the study of history, Nietzsche criticizes F. A. Wolf’s organic systematization of the sciences of antiquity (inspired by Schelling and Hegel) and foregrounds the aesthetic dimension of philology. Contrary to Wolf, Nietzsche believes that historical investigation is subordinate to the essential pedagogical function of philology; and only through its aesthetic component can philology establish which literary works of antiquity are to be considered truly “classical.” The debate on the Homeric question after the publication of Wolf’sProlegomena ad Homerum(1795) illustrates that philologists have paradoxically become opponents and “destroyers” of the ideal of antiquity. Nietzsche shows how a methodological approach inspired by Schopenhauer’s philosophy can revive the relationship between philology and art. Nietzsche’s arguments to counter Wolf’s thesis about the problem of Homer’s personality implicitly rest on Schopenhauer’s aesthetics. In particular, through Schopenhauer’s conception of genius, Nietzsche rehabilitates the individuality of the poetic author of the Iliad and Odyssey, even though this poet does not correspond to the one referred to as “Homer” in antiquity.
Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
Authors: Oyeyiola Yetunde Bunmi , Adeosun Christianah Iyanuoluwa 
Published: April 2022

Abstract
Alkaline soil conditions are serious challenges to optimal crop production on irrigated farmlands in arid and semi-arid regions of the world. Unique characteristics of biochar had been utilized in the amelioration of many problematic soils but its use in sodic soil management is not popular in Nigeria. Ameliorative effects of biochar types prepared from poultry manure co-pyrolyzed with or without urea fertilizer were evaluated on soil organic carbon and selected soil chemical characteristics of a simulated sodic soil. The results from the six weeks incubation trial revealed the ability of the biochar types to reduce soil pH from the initial 10.38 to 7.91–10.29 in high sodic (HS) and from initial 9.70 to a range of 7.51–8.39 in low sodic (LS) soil situations compared to 9.88 (HS) and 6.82 (LS) in sole urea treated soil. This accounted for up to 51 and 57% reduction in exchangeable sodium content and percentage (ESP), respectively and 28% increases in exchangeable Ca in the sodic soils. Poultry manure biochar co-pyrolyzed with urea was most effective in reducing exchangeable sodium and ESP in the soils while poultry manure biochar not co-pyrolyzed with urea was highest in reducing soil pH. Poultry manure biochar not spiked with urea was most superior in increasing soil organic carbon in low sodic situation.
“Every fox praises its own tail”. Jan Blahoslav (1523–1571) on Slavic dialects
Authors: Seldeslachts Herman , Van Rooy Raf 
Published: April 2022

Summary
Jan Blahoslav (1523–1571) was one of the first – if not the first – to devote a separate chapter to the phenomenon of vernacular diatopic variation in his Czech grammar. His pioneering attempts at making sense of this issue have thus far remained understudied, especially outside of the Czech Republic. In this contribution, we open up this important text, largely written in Czech, to a wider audience by means of an annotated English translation. In addition, we frame his interest in dialectal variation in the intellectual trends of 16th-century language study, especially within the Protestant circles in which Blahoslav was active.