bluuebunny/crossref_metadata_2025_split huggingface dataset:
CNES-ESA satellite contribution to the operational monitoring of volcanic activity: The 2021 Icelandic eruption of Mt. Fagradalsfjall
Authors: Gouhier Mathieu , Pinel Virginie , Belart Joaquín M. C. , De Michele Marcello , Proy Catherine , Tinel Claire , Berthier Etienne , Guéhenneux Yannick , Gudmundsson Magnus Tumi , Óskarsson Birgir V. , Gremion Shan , Raucoules Daniel , Valade Sébastien , Massimetti Francesco , Oddsson Bjorn 
Published: August 2022

AbstractWithin the framework of the CIEST2 (Cellule d'Intervention d'Expertise Scientifique et Technique new generation) and thanks to the support of CNES, the French space agency, the first phase of the Fagradalsfjall eruption was exceptionally well covered by high resolution optical satellite data, through daily acquisitions of Pléiades images in stereo mode. In this study, we show how Pléiades data provided real-time information useful for the operational monitoring of the ongoing eruption. An estimation of the volume of lava emitted as well as the corresponding effusion rate could be derived and delivered to the civil protection less than 6 h after the data acquisition. This information is complementary to and consistent with estimates obtained through the HOTVOLC service using SEVIRI (Spinning Enhanced Visible and Infrared Imager) sensor on-board Meteosat Second Generation (MGS) geostationary satellites, operated by the European Space Agency (ESA), characterized by a lower spatial resolution and a higher temporal one. In addition to the information provided on the lava emission, Pléiades data also helped characterize the intensity of the eruption by providing insight into the elevation and the velocity of the volcanic plume. The survey of this effusive eruption, well anticipated by a series of precursors, is a proof of concept of the efficiency of optical/thermal satellite data for volcanic crisis real-time monitoring.
The development and education of a workforce in childhood cancer services in low- and middle-income countries: a scoping review protocol
Authors: Cayrol Julie , Ilbawi André , Sullivan Michael , Gray Amy 
Published: August 2022

Abstract
Background
An estimated 400,000 children develop cancer worldwide. Of those, 90% occur in low- and middle-income countries, where survival rates can be as low as 30%. To reduce the childhood cancer survival gap between high- and low- and middle-income countries (LMIC), the World Health Organization launched the Global Initiative for Childhood Cancer in 2018, to support governments in building sustainable childhood cancer programs, with the aim to increase access and quality of care for children with cancer. Developing a high-quality and trained workforce is key to the success of childhood cancer services, but more information is needed on the interventions used to develop and train a workforce. The objective of this review is to understand the key factors described in the literature in relation to the development and training of a workforce in childhood cancer (defined here as ages 0–19) in LMIC, including challenges, interventions and their outcomes.

Methods
We will include sources of evidence that describe the development or training of a childhood cancer workforce in health services that diagnose, refer or treat children and adolescents with cancer, in low- and middle-income countries as defined by the World Bank. The following databases will be searched: OVID Medline, Embase and Pubmed from 2001 to present with no restriction of language. Grey literature searches will also be performed in Proquest Dissertation and Theses, as well as relevant organizations’ websites, and conference proceedings will be searched in conference websites. In addition, references lists will be reviewed manually. Two people will screen abstracts and full-texts and extract data. Data will be presented in a table or chart, with an accompanying narrative summary responding to the review questions. A framework synthesis will be conducted: data will be charted against a framework adapted from the 2016 WHO Global Strategy for Human Resources for Heath: Workforce 2030.

Discussion
This scoping review will allow to map the existing literature on workforce development in LMIC, identify potential interventions and highlight data and knowledge gaps. This constitutes a first step towards adopting successful strategies more broadly, formulating research priorities and developing effective policies and interventions.

Systematic review registration
Open Science Framework osf.io/3mp7n
Overview of systematic reviews of health interventions that aim to prevent and treat overweight and obesity among children
Authors: Denova-Gutiérrez Edgar , Méndez-Sánchez Lucía , Araiza-Nava Berenice , González-Rocha Alejandra , Shamah Teresa , Bonvechio Anabelle , Barquera Simón , Rivera Juan 
Published: August 2022

Abstract
Background
Childhood overweight and obesity is a global public health issue. Although there is evidence of a reduced prevalence in some countries, there is still much controversy about the efficacy of health interventions that aim to prevent and treat obesity in this specific population. The objective of the present study is to develop an overview of systematic reviews (OSRs) that assesses the effects of school-based, family, and multi-component health interventions for the prevention and treatment of obesity, change in physical activity, dietary, and/or hydration behaviors, and change in metabolic risk factors in school-aged children.

Methods
This protocol was developed using the methodology proposed by Cochrane. It outlines a comprehensive search in 12 electronic databases to identify systematic reviews of health interventions, including studies that evaluate and how to prevent and/or treat overweight and/or obesity in children aged 6 to 12 years. The risk of bias of the included Systematic Reviews will be assessed with the ROBIS tool.

Discussion
Since the OSRs methodology’s purpose is only to harmonize evidence from open access publications, ethical consent is not necessary for the present protocol. In terms of diffusion, a paper will be submitted for publication in a scientific journal to describe the main results obtained through the OSRs.

Trial registration
The present overview of the systematic review protocol has been registered in PROSPERO (ID number 218296).
Anomaly detection in microservice environments using distributed tracing data analysis and NLP
Authors: Kohyarnejadfard Iman , Aloise Daniel , Azhari Seyed Vahid , Dagenais Michel R. 
Published: August 2022

AbstractIn recent years DevOps and agile approaches like microservice architectures and Continuous Integration have become extremely popular given the increasing need for flexible and scalable solutions. However, several factors such as their distribution in the network, the use of different technologies, their short life, etc. make microservices prone to the occurrence of anomalous system behaviours. In addition, due to the high degree of complexity of small services, it is difficult to adequately monitor the security and behavior of microservice environments. In this work, we propose an NLP (natural language processing) based approach to detect performance anomalies in spans during a given trace, besides locating release-over-release regressions. Notably, the whole system needs no prior knowledge, which facilitates the collection of training data. Our proposed approach benefits from distributed tracing data to collect sequences of events that happened during spans. Extensive experiments on real datasets demonstrate that the proposed method achieved an F_score of 0.9759. The results also reveal that in addition to the ability to detect anomalies and release-over-release regressions, our proposed approach speeds up root cause analysis by means of implemented visualization tools in Trace Compass.
A qualitative study examining the impact of multidrug-resistant organism (MDRO) carriage on the daily lives of carriers and parents of carriers with experiences of hospital precautionary measures
Authors: Baron Ruth , Eilers Renske , Haverkate Manon R. , Feenstra Sabiena G. , Timen Aura 
Published: August 2022

Abstract
Background
Multidrug-resistant organism (MDRO) carriage may have an adverse impact on the quality of life of carriers, in particular those who have experienced hospital precautionary measures. This study aims to gain a deeper understanding of how MDRO carriage has affected the daily lives of carriers with these experiences.

Methods
This was a qualitative study based on 15 semi-structured interviews with MDRO carriers or parents of carriers, which were analysed by thematic analysis.

Results
Three main themes were identified: (1) Feeling dirty and unworthy portrays the feelings that MDRO carriers often expressed and how these were related to the language usage describing the MDRO, the perceived avoidance by staff and those in their personal networks, and the effects of the precautionary measures implemented in the hospital. (2) MDROs are invisible, but impact is visible covers how the microbe, despite its apparent invisibility, still impacted carriers in their physical and psychological health. MDRO carriage disrupted their lives, by affecting their other unrelated medical conditions at times and by causing varying levels of fear for their own and others’ health. (3) Carrying the burden on one’s own shoulders describes the lingering questions, uncertainties and confusion that carriers continued to live with and the perceived burden and responsibility that lay on their own shoulders with respect to carrying and preventing the transmission of the MDRO.

Conclusions
MDRO carriage can negatively influence the quality of people’s lives in various ways. Improved support and sensitivity from health care providers (HCPs) are needed to address feelings of unworthiness among MDRO carriers and the fears that many experience. Clearer information and guidelines are also needed from HCPs to address the many questions and uncertainties that MDRO carriers face outside of the hospital in their daily lives.
ARDS associated acute brain injury: from the lung to the brain
Authors: Ziaka Mairi , Exadaktylos Aristomenis 
Published: August 2022

AbstractA complex interrelation between lung and brain in patients with acute lung injury (ALI) has been established by experimental and clinical studies during the last decades. Although, acute brain injury represents one of the most common insufficiencies in patients with ALI and acute respiratory distress syndrome (ARDS), the underlying pathophysiology of the observed crosstalk remains poorly understood due to its complexity. Specifically, it involves numerous pathophysiological parameters such as hypoxemia, neurological adverse events of lung protective ventilation, hypotension, disruption of the BBB, and neuroinflammation in such a manner that the brain of ARDS patients—especially hippocampus—becomes very vulnerable to develop secondary lung-mediated acute brain injury. A protective ventilator strategy could reduce or even minimize further systemic release of inflammatory mediators and thus maintain brain homeostasis. On the other hand, mechanical ventilation with low tidal volumes may lead to self-inflicted lung injury, hypercapnia and subsequent cerebral vasodilatation, increased cerebral blood flow, and intracranial hypertension. Therefore, by describing the pathophysiology of ARDS-associated acute brain injury we aim to highlight and discuss the possible influence of mechanical ventilation on ALI-associated acute brain injury.
Active acoustic telemetry reveals ontogenetic habitat-related variations in the coastal movement ecology of the white shark
Authors: Gennari E. , Irion D. T. , Cowley P. D. 
Published: August 2022

Abstract
Background
Little is known about the fine-scale behavioural choices white sharks make. The assessment of movement at high spatio-temporal resolution can improve our understanding of behavioural patterns. Active acoustic telemetry was used along a coastal seascape of South Africa to investigate the movement-patterns of 19 white sharks tracked for 877 h within habitats known to host different prey types.

Results
A three-state hidden Markov model showed higher ontogenetic variability in the movements of white sharks around estuary-related coastal reef systems compared to around a pinniped colony. Our results further suggest white sharks (1) use the same searching strategy in areas where either pinnipeds or fishes are present; (2) occupy sub-tidal reef habitats possibly for either conserving energy or recovering energy spent hunting, and (3) travel directly between the other two states.

Conclusions
White sharks appear not to simply roam coastal habitats, but rather adopt specific temporally optimized behaviours associated with distinct habitat features. The related behaviours are likely the result of a balance among ontogenetic experience, trophic niche, and energetics, aimed at maximizing the use of temporally and spatially heterogeneous environments and resources. The possible implications for the future conservation of white sharks in coastal areas are discussed, with particular attention to South Africa’s present conservation and management challenges.
The Japanese version of the Material Values Scale: construct assessment and relationship with age, personality, and subjective well-being
Authors: Ohno Hiroshi , Lee Kyung-Tae , Maeno Takashi 
Published: August 2022

Abstract
Background
Materialism indicates the extent to which an individual’s life is focused on consumerism, or the acquisition of money and possessions. The Material Values Scale (MVS), comprising the factors “success,” “centrality,” and “happiness,” is a well-known rating scale for materialism. However, a Japanese version of the materialism scale has not yet been established, and the details of the factors and effects related to materialism have not yet been clarified in Japan. The purpose of this study is to develop and evaluate the Japanese version of the MVS (J-MVS).

Methods
We developed the translated J-MVS using a back-translation process. To validate and evaluate the scale based on an online survey, we recruited 500 people, with 100 participants (50 men, 50 women) in five age groups, from 20 to 69 years. We compared and evaluated several factor structure models based on exploratory and confirmatory factor analysis. To evaluate the external criterion-referenced validity of the developed J-MVS scale, we examined the relationship between age, personality, and well-being, which have shown stable relationships with materialism in previous studies.

Results
We developed two six-item dual-factor models. Both models showed significant positive correlations with social comparison orientation and neuroticism, and had significant negative correlations with various subjective well-being indices, suggesting sufficient external criterion-referenced validity. The J-MVS comprising six positive-worded items (J-MVS-P6; without any reverse-worded items) showed a higher correlation with other indicators than the version comprising six items representing all item types and was considered to have higher external criterion-referenced validity.

Conclusions
We propose the J-MVS-P6 for use as a materialism scale in Japan. Compared with the findings from other countries, materialism in Japan may be more closely related to subjective well-being. This scale may be used to examine the effectiveness of various intervention methods for improving individuals’ happiness, based on changes in factors closely related to materialism in Japan.
Phenological drivers of ungulate migration in South America: characterizing the movement and seasonal habitat use of guanacos
Authors: Candino Malena , Donadio Emiliano , Pauli Jonathan N. 
Published: August 2022

AbstractBackgroundMigration is a widespread strategy among ungulates to cope with seasonality. Phenology, especially in seasonally snow-covered landscapes featuring “white waves” of snow accumulation and “green waves” of plant green-up, is a phenomenon that many migratory ungulates navigate. Guanacos (Lama guanicoe) are native camelids to South America and might be the last ungulate in South America that migrates. However, a detailed description of guanacos´ migratory attributes, including whether they surf or jump phenological waves is lacking.MethodsWe quantified the migratory movements of 21 adult guanacos over three years in Patagonia, Argentina. We analyzed annual movement patterns using net squared displacement (NSD) and home range overlap and quantified snow and vegetation phenology via remotely sensed products.ResultsWe found that 74% of the individual guanacos exhibited altitudinal migrations. For migratory guanacos, we observed fidelity of migratory ranges and residence time, but flexibility around migration propensity, timing, and duration of migration. The scarce vegetation and arid conditions within our study area seemed to prevent guanacos from surfing green waves; instead, guanacos appeared to avoid white waves.ConclusionOur study shows that guanaco elevational migration is driven by a combination of vegetation availability and snow cover, reveals behavioral plasticity of their migration, and highlights the importance of snow phenology as a driver of ungulate migrations.
Construction of an Escherichia coli cell factory to synthesize taxadien-5α-ol, the key precursor of anti-cancer drug paclitaxel
Authors: Wu Qing-Yang , Huang Zheng-Yu , Wang Jin-Yi , Yu Hui-Lei , Xu Jian-He 
Published: August 2022

AbstractPaclitaxel (Taxol™), an alkaloid of diterpenoid family, is one of the most widely used anti-cancer drugs due to its effectiveness against a variety of tumors. Rather than directly extraction and chemical synthesis of paclitaxel or its intermediates from yew plants, construction of a microbial cell factory for paclitaxel biosynthesis will be more efficient and sustainable. The challenge for biosynthesis of paclitaxel lies on the insufficient precursor, such as taxadien-5α-ol. In this study, we report a recombinant Escherichia coli strain constructed with a heterologous mevalonate pathway, a taxadiene synthase from yew, and a cytochrome P450-mediated oxygenation system for the de novo production of taxadien-5α-ol, the first product of the multi-step taxadiene oxygenation metabolism. The key enzymes including taxadiene synthases and cytochrome P450 reductases were screened, and the linker for fusing taxadiene-5α-hydroxylase with its reductase partner cytochrome P450 reductase was optimized. By reducing the metabolic burden and optimizing the fermentation conditions, the final production of total oxygenated taxanes was raised up to 27 mg L−1 in a 50-mL flask cultivation, of which the yield of taxadien-5α-ol was 7.0 mg L−1, representing approximately a 12-fold and 23-fold improvements, respectively, as compared with the initial titers. The engineered MVA pathway for the overproduction of terpenoid precursors can serve as an efficient platform for the production of other valuable terpenoids.
Graphical Abstract
Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study
Authors: Curry Jordan , Lind Michael , Short Camille E. , Vandelanotte Corneel , Evans Holly E. L. , Pearson Mark , Forbes Cynthia C. 
Published: August 2022

Abstract
Background
Lung cancer is the leading cause of cancer-related death globally. Physical activity and exercise provide unequivocal benefits to those living with and beyond lung cancer. However, few of those living with and beyond cancer meet the national physical activity guidelines. Various barriers exist for this population’s engagement in physical activity and exercise, such as the lack of knowledge and lack of tailored information, little access to exercise specialists, fatigue, and mobility challenges. Digitally delivered programmes have the potential to address several of these barriers, with techniques like “computer-tailoring” available to enable the delivery of tailored content at a time and place that is convenient. However, evaluation of such programmes is needed prior to implementation. This protocol describes a single group study that will examine the feasibility and acceptability of an online tool (ExerciseGuide UK) that provides those living with and beyond lung cancer web-based computer-tailored physical activity prescription and modules underpinned by behaviour change theories.

Methods
Thirty-five individuals diagnosed with lung cancer, or cancer affecting the lung (e.g. pleural mesothelioma), will be recruited into a single-intervention arm. The platform will provide tailored resources and a personalised physical activity programme using IF-THEN algorithms. Exercise prescription will be tailored on factors such as self-reported specific pain location, exercise history, and current physical fitness. In addition, modules grounded in behaviour change will supplement the physical activity programme and will focus on topics such as exercise benefits, safety, goal setting, and tracking. The primary outcome will be assessed using pre-established criteria on feasibility and mixed-methods approach for acceptability.
Secondary outcomes will explore changes in the physical activity, quality of life, anxiety, and depression.

Discussion
This manuscript describes the protocol for a study examining the feasibility and acceptability of a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer. The publication of this protocol aims to increase the transparency of the methods, report pre-determined criteria, and aid replication of the study and associated materials. If feasible and acceptable, this intervention will inform future studies of digital-based interventions.

Trail registration
ClinicalTrails.gov, NCT05121259. Registered on November 16, 2021.