bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spätzle1 is a constituent of the extracellular signaling pathway that promotes nodule formation, a cell‐mediated immune response, in caterpillar hemolymph
Authors: Tang Shuyi , Tezuka Moeko , Otsuka Hinata , Sato Ryoichi 
Published: October 2022

AbstractThe existence of an extracellular signaling pathway that mediates nodule formation, a cell‐mediated immune response, has been reported in Bombyx mori larvae. In this pathway, C‐type lectins and the hemolymph serine proteinase BmHP‐8 function in pathogen associated molecular pattern (PAMPs) recognition and signaling transduction. However, which molecule elicits the cellular response at the end of the pathway is unknown. In this study, the Toll ligand Bombyx mori Spätzel1 was shown to be involved in the pathway by applying anit‐Spätzel1 antiserum in an in vitro nodule‐like aggregate formation assay and an in vivo nodule formation assay.
Star anise from a fifteenth century Indonesian shipwreck
Authors: Castillo Cristina Cobo , Fahy Brian , Fuller Dorian Q. 
Published: October 2022

AbstractMaritime trade routes in Southeast Asia date to at least the last millennium BC evidenced by excavations of port‐cities, entrepôts and early coastal polities in Peninsular Thailand, the Mekong Delta and Island Southeast Asia. This trade network intensified over the next millennium and by the fifteenth century, the number of trade goods throughout Medieval Southeast Asia was prolific. The bulk of studied material comprises trade ceramics, particularly in archaeological investigations of shipwreck cargoes which provide information on regional trading patterns. Although ceramic assemblages constitute the bulk of shipwreck cargo, other types of material have also been found, including the spice star anise. In this paper, we focus on the organic contents from two jars found in the Bakau shipwreck dating to the early fifteenth century AD. The finds are significant as this spice (star anise, Illicium verum) is being transported together with items of high value for trade.
Robust sliding‐mode observer‐based multiple‐fault diagnosis scheme
Authors: Gao Sheng , Ma Guangfu , Guo Yanning 
Published: October 2022

AbstractIn this study, we simultaneously evaluate the multiple‐fault diagnosis problem of a class of Lipschitz nonlinear systems with actuator and sensor faults and unknown input disturbances. A nonsingular system transformation is used to transform the original system into two subsystems for multiple‐fault diagnosis: subsystems 1 and 2. At the system level, two robust sliding‐mode observers (RSMOs) are proposed. An RSMO is designed for subsystem 1 to detect actuator faults subjected to unknown input disturbances, and another RSMO is designed for subsystem 2 to detect sensor faults subjected to actuator faults. At the component level, a bank of RSMOs is proposed to detect and isolate actuators (sensors) with faults using a dedicated observer scheme. The reachability of RSMOs is comprehensively investigated in the estimation error space. Accordingly, the proposed observer parameters are designed as an optimization problem and solved using the linear matrix inequality (LMI) optimization technique. The effectiveness of the proposed multiple‐fault diagnosis scheme was validated through simulations of a modified seventh‐order aircraft system.
Anti‐rheumatoid arthritis effects of Xanthii Fructus by affecting the PI3K‐AKT signaling pathway based on TMT‐labeled quantitative proteomics
Authors: Jiang Hai , Zhang Jiaxu , Yu Huan , Hou Ajiao , Wang Song , Wang Xuejiao , Zheng Senwang , Yang Liu , Kuang Haixue 
Published: October 2022

AbstractRheumatoid arthritis is a systemic autoimmune disease characterized by chronic symmetrical multiple arthritis. Current traditional counter‐therapies are expensive and have side effects. Xanthii Fructus has effects in expelling wind and cold, draining the nasal orifice, and removing wind and dampness. However, its mechanism of action against rheumatoid arthritis is unknown. In this paper, the mechanism of the anti‐ rheumatoid arthritis effect of Xanthii Fructus is studied by proteomics. The experimental results show that it could significantly reduce serum inflammatory factor levels, alleviate joint edema, improve vasodilation and congestion, and significantly reduce the number of inflammatory cells. Proteomics results show that the PI3K‐AKT signaling pathway is the key pathway for Xanthii Fructus to treat rheumatoid arthritis. In this study, we obtained a new understanding of the mechanism of Xanthii Fructus in the treatment of rheumatoid arthritis, which provided a theoretical basis for its prevention and treatment and laid the foundation for further research.
Corporate climate reporting of European banks: Are these institutions compliant with climate issues?
Authors: Friedrich Tim Jan , Velte Patrick , Wulf Inge 
Published: October 2022

AbstractThis article focuses on climate disclosures from STOXX Europe 600 banks during the 2017–2020 period, comprising 152 company years. Specifically, we analyze compliance based on general and bank‐specific recommendations of the Task Force on Climate‐related Financial Disclosures. Although our results indicate an overall increase in climate reporting quality over time, we identify major reporting gaps, such as consideration of forward‐looking information (particularly related to scenario analyses). We also stress that the bank‐specific recommendations are taken into account rather insufficiently. This study stands to benefit mostly researchers, business practices, and regulatory bodies owing to the future standardization of European and global sustainability reporting frameworks.
Secondary malignancies and survival of FCR‐treated patients with chronic lymphocytic leukemia in Central Europe
Authors: Kósa Fruzsina , Nečasová Tereza , Špaček Martin , Giannopoulos Krzysztof , Hus Iwona , Jurková Tereza , Koriťáková Eva , Chrápavá Marika , Nováčková Martina , Katinová Ivana , Krejčí Denisa , Jujka Adam , Mátrai Zoltán , Vályi‐Nagy István , Robak Tadeusz , Doubek Michael 
Published: October 2022

AbstractThis is the first large‐scale cross‐country analysis of patients with chronic lymphocytic leukemia (CLL) aimed to evaluate the incidence, types, and key prognostic factors of secondary malignancies, and to assess the impact on overall survival based on retrospective claims data from three Central European countries. We analyzed 25,814 newly diagnosed CLL patients from Czechia, Hungary, and Poland; 10,312 (39.9%) patients were treated for CLL in study periods between 2004 and 2016. Out of the treated patients, 1986 (19.3%) received the FCR therapy in the first line and 779 (7.6%) received FCR in subsequent lines. We observed that 33.7% of treated patients developed secondary malignancies during the study. Based on country estimates, the probability to develop a secondary malignancy within 4 years since starting the first‐line FCR therapy ranged between 28.0% and 36.8%. We found the age at diagnosis, male gender, any malignancy prior to the CLL diagnosis, and the CLL treatment to be the key risk factors for developing secondary malignancies. Specifically, the FCR therapy was a statistically significant (p < 0.001) prognostic factor for risk increase with the hazard ratio between 1.46 and 1.60. Across the three Central European countries, we observed consistent results indicating FCR increased the risk of secondary malignancies in CLL patients. We conclude that secondary malignancies are clearly an undervalued burden for CLL patients, caregivers, and the healthcare system. When evaluating new therapies in regulatory and reimbursement decision making, the factor of secondary malignancies deserves deeper considerations.
Use of multikinase inhibitors/lenvatinib concomitant with radioiodine for the treatment of radioiodine refractory differentiated thyroid cancer
Authors: Herranz Urbano Anido 
Published: October 2022

AbstractThyroid cancer is the most frequent endocrine tumor. However, in locally advanced or metastatic disease we have only two types of treatment at our disposal: radioactive iodine (RAI) when the disease is RAI‐sensitive and multikinase inhibitors (MKIs), lenvatinib and sorafenib, when the disease becomes RAI‐refractory (RR). This review revisits the published data on the potential combination of MKIs/lenvatinib with RAI in RR‐differentiated thyroid cancer and evaluates some special situations where this combination may be of particular interest. The combination of MKIs/lenvatinib with RAI could, at least hypothetically, improve the efficacy seen in both treatments alone via a synergistic effect and with a lower rate of toxicity rates. Early preclinical data support this notion, while its generalized use awaits the results of ongoing clinical trials.
Multi‐omics analysis of the oncogenic value of copper Metabolism‐Related protein COMMD2 in human cancers
Authors: Tai Panpan , Wang Zhanwang , Chen Xinyu , Chen Aiyan , Gong Lian , Cheng Yaxin , Cao Ke 
Published: October 2022

AbstractBackgroundThe copper metabolism MURR1 domain (COMMD) protein family is involved in tumorigenicity of malignant tumors. However, as the member of COMMD, the role of COMMD2 in human tumors remains unknown.MethodsWe used The Cancer Genome Atlas (TCGA), Genotype Tissue Expression (GTEx), Human Protein Atlas (HPA) database, Cancer Cell Line Encyclopedia (CCLE) platform, univariate Cox regression analysis, Kaplan–Meier curve, cBioPortal, UALCAN database, Sangerbox online platform, GSCA database gene set enrichment analysis (GSEA), and GeneMANIA to analyze the expression of COMMD2, its prognostic values, genomic alteration patterns, and the correlation with tumor stemness, tumor mutational burden (TMB), microsatellite instability (MSI), and immune infiltrates, drug sensitivity, and gene function enrichment in pan‐cancer. qRT‐PCR, CCK‐8, EdU, wound healing, and transwell migration assays were performed to confirm the function of COMMD2.ResultsCOMMD2 was strongly expressed in most cancer types. Elevated COMMD2 expression affects the prognosis, clinicopathological stage, and molecular or immune subtypes of various tumors. Moreover, promoter hypomethylation and mutations in the COMMD2 gene may be associated with its high expression and poor survival. Additionally, we discovered that COMMD2 expression was linked to tumor stemness, TMB, MSI, immune cell infiltration, immune‐checkpoint inhibitors, and drug sensitivity in pan‐cancer. Furthermore, the COMMD2 gene co‐expression network is constructed with GSEA analysis, displaying significant interaction of COMMD2 with E2F targets, G2‐M checkpoint, and mitotic spindle in bladder cancer (BLCA). Finally, RNA interference data showed suppression of COMMD2 prevented proliferation and migration of BLCA and uterine corpus endometrial carcinoma (UCEC) cells.ConclusionOur findings shed light on the COMMD2 functions in human cancers and demonstrate that it is a promising prognostic biomarker and therapeutic target in pan‐cancer.
Clinical models to predict lymph nodes metastasis and distant metastasis in newly diagnosed early esophageal cancer patients: A population‐based study
Authors: Chen Hong , Wu Junxian , Guo Wanting , Yang Lihang , Lu Linbin , Lin Yihong , Wang Xuewen , Zhang Yan , Chen Xi 
Published: October 2022

AbstractBackgroundPatients with early esophageal cancer (EC) receive individualized therapy based on their lymph node metastasis (LNM) and distant metastasis (DM) status; however, deficiencies in current clinical staging techniques and the issue of cost‐effectiveness mean LNM and DM often go undetected preoperatively. We aimed to develop three clinical models to predict the likelihood of LNM, DM, and prognosis in patients with early EC.MethodThe Surveillance, Epidemiology, and End Results database was queried for T1 EC patients from 2004 to 2015. Multivariable logistic regression and Cox proportional hazards models were used to recognize the risk factors of LNM and DM, predict overall survival (OS), and develop relevant nomograms. Receiver operating characteristic (ROC)/concordance index and calibration curves were used to evaluate the discrimination and accuracy of the three nomograms. Decision curve analyses (DCAs), clinical impact curves, and subgroups based on model scores were used to determine clinical practicability.ResultsThe area under the curve of the LNM and DM nomograms were 0.668 and 0.807, respectively. The corresponding C‐index of OS nomogram was 0.752. Calibration curves and DCA showed an effective predictive accuracy and clinical applicability. In patients with T1N0M0 EC, surgery alone (p < 0.01) proved a survival advantage. Chemotherapy and radiotherapy indicated a better prognosis in the subgroup analysis for T1 EC patients with LNM or DM.ConclusionsWe created three nomograms to predict the likelihood of LNM, DM, and OS probability in patients with early EC using a generalizable dataset. These useful visual tools could help clinical physicians deliver appropriate perioperative care.
Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight
Authors: Singh Rahul , Bhardwaj Vijay K. , Purohit Rituraj 
Published: October 2022

AbstractThe quick widespread of the coronavirus and speedy upsurge in the tally of cases demand the fast development of effective drugs. The uridine‐directed endoribonuclease activity of nonstructural protein 15 (Nsp15) of the coronavirus is responsible for the invasion of the host immune system. Therefore, developing potential inhibitors against Nsp15 is a promising strategy. In this concern, the in silico approach can play a significant role, as it is fast and cost‐effective in comparison to the trial and error approaches of experimental investigations. In this study, six turmeric derivatives (curcuminoids) were chosen for in silico analysis. The molecular interactions, pharmacokinetics, and drug‐likeness of all the curcuminoids were measured. Further, the stability of Nsp15‐curcuminoids complexes was appraised by employing molecular dynamics (MD) simulations and MM‐PBSA approaches. All the molecules were affirmed to have strong interactions and pharmacokinetic profile. The MD simulations data stated that the Nsp15‐curcuminoids complexes were stable during simulations. All the curcuminoids showed stable and high binding affinity, and these curcuminoids could be admitted as potential modulators for Nsp15 inhibition.
Best practices in college governance
Authors: Kater Susan T. , Cloud Robert C. , Fossey Richard 
Published: October 2022

AbstractThis chapter provides an overview of the important work of community college trustees and includes best practices as well as the contrasting challenges of rogue trustees and activist boards. Whether a board is made up of trustees who are elected, appointed, or a combination of the two, there are things that colleges should, and could do which would enhance effective governance. Several best practices are presented to inform college leaders and boards of trustees.
Community college governance and trustees as advocates for fiscal support
Authors: White Carol Cutler 
Published: October 2022

AbstractCommunity college boards of trustees are not highly visible, but they play a vital role in college and student success through governance and oversight of the mission of open access higher education. The stakes are high as community colleges compete for scarce resources in state budgets making the local and state‐level trustee/governing role as fierce advocates of utmost importance. This chapter describes the different roles and functions of community college trustees across the states with a particular focus on college finance. The article begins by describing community college governance arrangements and duties of state level boards followed by a description of duties for locally governed colleges. The chapter then moves to a discussion of state and local budgetary support of community colleges. The chapter closes with a discussion of political power and implications for trustees to expand budgetary support for community colleges through advocacy.
Successful treatment with cyclosporine and guselkumab for pityriasis rubra pilaris
Authors: Nishimura Mai , Kondo Makoto , Habe Koji , Hayashi Akinobu , Yamanaka Keiichi 
Published: October 2022

AbstractA man with pityriasis rubra pilaris (PRP) showed no improvement in skin symptoms despite treatment with several drugs. The patient was diagnosed as having type 1 PRP. Combination therapy with cyclosporine and guselkumab improved his skin condition. Here, we propose a novel therapeutic strategy for intractable PRP.
Extensive keloid scarring in a patient with pemphigus vulgaris
Authors: Elinkichari Dorsaf , Zaouak Anissa , Chamli Amal , Hammami Houda , Fenniche Samy 
Published: October 2022

AbstractSince pemphigus blisters are intraepidermal, scarring should induce at most a post‐inflammatory hyperpigmentation. We describe a very atypical and unusual course of pemphigus vulgaris with extensive keloid formation despite high systemic steroids. This could be promoted by the severe flare of the disease, the delay of scarring, and the superinfection.
Photocatalytic Reduction of CO2by Highly Efficient Homogeneous FeIICatalyst based on 2,6‐Bis(1’,2’,3’‐triazolyl‐methyl)pyridine. Comparison with Analogues.
Authors: Gracia Lisa‐Lou , Barani Elham , Braun Jonas , Carter Anthony B. , Fuhr Olaf , Powell Annie K. , Fink Karin , Bizzarri Claudia 
Published: October 2022

AbstractFully earth‐abundant and highly efficient systems for producing syngas CO/H2through photocatalytic reduction from CO2are essential to approach a sustainable way of closing the carbon cycle. Herein, the synthesis and characterization of a new iron complex, FeIIL(NCS)2py, coordinated to an N,N,N‐pincer ligand 2,6‐bis(4’‐phenyl‐1’,2’,3’‐triazol‐1’‐yl‐methyl)pyridine (L), two isothiocyanate groups (NCS) and one pyridine is reported. Its catalytic activity in the photo‐driven reduction of carbon dioxide has been investigated and compared with its CoIIanalogue (CoL(NCS)2py) and their homoleptic complexes ML2. In this work, the catalysts are used in combination with the heteroleptic complex [CuI(dmp)(DPEphos)], where dmp is 2,9‐dimethyl‐1,10‐phenanthroline and DPEPhos is bis[(2‐diphenylphosphino)phenyl] ether, to reach entirely earth‐abundant systems. The new iron heteroleptic complex FeIIL(NCS)2py showed considerable activity with a TONCOof 576 obtained after 4 h (TOF=144 h−1) through visible light (λ=420 nm) and a quantum yield of 7.1 %.
Atomic Dual‐Site Ni/Co‐Decorated Carbon Nanofiber Paper for Efficient O2 Electrocatalysis and Flexible Zn‐Air Battery
Authors: Liu Nianxi , Kumar Anuj , Li Zongge , Liu Zhicheng , Zhao Changkai , Meng Xiangshe , Wang Yaqun , Yang Lei , Zhang Guoxin 
Published: October 2022

AbstractThe fabrication of flexible catalytic films with isolated single/dual‐atomic sites and their integration in wearable electronics is challenging. Herein, an efficient method to prepare atomically dispersed binary Ni/Co‐decorated flexible carbon nanofiber (NiCo‐CNF) film using formamide‐derived cyano‐specific NiCo‐NC as nanofillers was developed. The optimized Ni1Co1‐CNF catalytic film, having large‐area, high density of adjacent Ni‐N4 and Co‐N4 active sites, and good mechanical properties under repeated bending and release conditions, possessed high catalytic activity towards oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The ORR/OER potential difference (ΔE10) for Ni1Co1‐CNF at 10.0 mA cm−2 was highly comparable with the Pt/C+RuO2 mixture. In addition, flexible Ni1Co1‐CNF‐assembled Zn‐air battery displayed very good mechanical robustness and cycling stability. Our work may inspire the fabrication of other atomic metal‐decorated films for membrane electrocatalysis.
Light Modulated Reversible “On‐Off” Transformation of Arylazoheteroarene Based Discotics in Nematic Organization
Authors: Kumar Pravesh , Bala Indu , De Ritobrata , Kumar Pal Santanu , Venkataramani Sugumar 
Published: October 2022

AbstractThree benzene‐1,3,5‐tricarboxamide (BTA) core‐based molecular systems appended with phenylazo‐3,5‐dimethylisoxazole photoswitches at the peripheral position through variable‐length alkoxy chains have been designed and synthesized. The supramolecular interactions of the mesogens provided discotic nematic liquid crystalline assembly as confirmed by polarized optical microscopy (POM) and X‐ray diffraction (XRD) studies. Spectroscopic studies confirmed the reversible photoswitching and excellent thermal stability of the photoswitched states in solution phase and thin film. Also, atomic force microscopic (AFM) and POM investigations demonstrated the morphological changes in the self‐assembly induced by the photoirradiation as monitored by the changes in the height profiles and optical appearance of the textures, respectively. Remarkably, the liquid crystalline discotic molecules showed reversible “on and off states” controlled by light at ambient temperature.
Solvent Effects on Ultrafast Charge Transfer Population: Insights from the Quantum Dynamics of Guanine‐Cytosine in Chloroform
Authors: Green James A. , Gómez Sandra , Worth Graham , Santoro Fabrizio , Improta Roberto 
Published: October 2022

AbstractInvited for the cover of this issue is the group of G. A. Worth, F. Santoro and R. Improta at UCL, ICOOM‐CNR and IBB‐CNR. The image depicts charge transfer from guanine to cytosine in solvent after the absorption of light. Read the full text of the article at 10.1002/chem.202201731.
Chemikalien aus klimaschädlichem CO2
Authors: Richter Michael 
Published: October 2022

AbstractAus Kohlenstoffdioxid wichtige Ausgangsmaterialien für Feinchemikalien machen – das funktioniert tatsächlich: Einem Forscherteam des Fraunhofer IGB ist es im Max‐Planck‐Kooperationsprojekt eBioCO2n erstmals gelungen, CO2 in einer auf dem Transfer von Elektronen basierenden Enzymkaskade zu fixieren und in einen festen Ausgangsstoff für die chemische Industrie umzuwandeln. Das Verfahren zur elektrobiokatalytischen CO2‐Fixierung wurde bereits publiziert und gilt als Hot Paper.
Recyclingtechnologien für Kunststoffabfälle
Authors: Krause Lars 
Published: October 2022

AbstractEinsparpotenziale lassen sich entlang des gesamten Herstellungsprozesses durch den Einsatz von Digitalisierungstechnologien identifizieren und umsetzen. Ziele können eine bessere Prozessstabilität oder vorausschauende Wartung sein.
Grünes Kerosin
Authors: Schär Dirk 
Published: October 2022

AbstractGefördert durch Wirtschaft und Politik arbeiten sieben deutsche und südafrikanische Partner nun gemeinsam an der Weiterentwicklung von Fischer‐Tropsch‐Katalysatoren für die effiziente und nachhaltige Produktion von grünen Flugzeugtreibstoffen. Das Projekt Care‐O‐Sene (Catalyst Research for Sustainable Kerosene) ist auf drei Jahre angelegt und hat die massentaugliche Kommerzialisierung grüner Kerosinprodukte ab 2025 zum Ziel.
PROTOCOL: Are tools that assess risk of violent radicalization fit for purpose? A systematic review
Authors: Hassan Ghayda , Brouillette‐Alarie Sébastien , Ousman Sarah , Madriaza Pablo , Varela Wynnpaul , Danis Emmanuel , Kilinc Deniz , Pickup David , Borokhovski Eugene ,   CPN‐PREV team
Published: October 2022

AbstractThis is the protocol for a Campbell systematic review. The main objective of this project is to gather, critically appraise, and synthesize evidence about the appropriateness and utility of tools used to assess the risk of violent radicalization.