bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronavirus stress and overeating: the role of anxiety and COVID-19 burnout
Authors: Wang Ruining , Ye Baojuan , Wang Peiyi , Tang Chunyan , Yang Qiang 
Published: May 2022

AbstractBackgroundThis study examined the role of anxiety and coronavirus disease 2019 (COVID-19) burnout in the relationship between coronavirus stress and overeating among Chinese college students during the COVID-19 pandemic.MethodsChinese college students (N = 2926;Mage = 19.90,SD = 1.47, range = 18–25 years old; 54.34% female) completed self-reported online questionnaires regarding coronavirus stress, anxiety, COVID-19 burnout, and overeating.ResultsAnxiety showed partially indirect effect on the association between coronavirus stress and overeating. COVID-19 burnout exacerbated the indirect pathway between coronavirus stress and overeating via anxiety.Discussion and conclusionThis is the first study, to our knowledge, that examines the underlying mechanisms of the coronavirus stress and overeating behavior association among Chinese college students. The results support several existing theories on stress and problematic eating behaviors and provide practical implications for prevention and intervention programs of overeating during the COVID-19 pandemic.
KetoCycle mobile app for ketogenic diet: a retrospective study of weight loss and engagement
Authors: Valinskas Sarunas , Aleknavicius Kasparas , Jonusas Justinas 
Published: May 2022

AbstractBackgroundThe ketogenic diet is one of the oldest diets that has been used for more than a centennial in the clinical setting, and it is gaining popularity as a measure to fight obesity, which is a major predisposing factor for many diseases to manifest, including diabetes mellitus, chronic heart disease, cancer, and others. Thus, we designed this retrospective investigation to determine if users of the mobile application KetoCycle achieved statistically significant weight loss outcomes.MethodsThe initial study cohort comprised 12,965 consecutive users who started using KetoCycle between January 2020 and December 2020. The final cohort comprised 10,269 users. The main parameters obtained from the database containing all self-reported data were gender, number of active days (AD), total time of use (TT), height, initial weight, and last recorded weight. The primary outcome of the study was weight loss. Statistical analyses were performed using IBM SPSS Statistics, version 26 (IBM Corp., Armonk, NY, USA). In addition, a standard multiple regression model was created to predict weight loss from significant actions.ResultsA retrospective analysis of KetoCycle user data showed that 87.3% of KetoCycle users lost some of their initial weight. Of those, 1645 users (18.3%) lost more than 10% of their initial body weight, 3528 (39.3%) users lost between 5 and 10% of their initial body weight, and 3796 (42.3%) users lost less than 5% of their body weight. When user activity was taken into account, it was found that active users lost statistically significantly more weight than non-active users (p < 0.05). App engagement was also associated with losing > 5% of initial weight. Using water tracking, weight tracking, and creation of a meals list within KetoCycle statistically significantly predicted weight loss in a multiple regression model.ConclusionsWe concluded that KetoCycle appeared as a promising mobile application suited for weight loss and weight control.Trial registrationThis retrospective chart review study was approved by BRANY IRB in January 2022 (registration ID.: 21-08-564-939).
Unfolding the learning behaviour patterns of MOOC learners with different levels of achievement
Authors: Li Shuang , Du Junlei , Sun Jingqi 
Published: May 2022

AbstractIn an open and flexible context of Massive Open Online Courses (MOOCs), learners who take final assessments exhibit the motivation for performance goals. The learning trajectories of this group usually provide more clues for course design and teaching improvement in that this group tend to interact more fully with course learning activities and resources for better learning outcomes. This study focused on such learners to investigate their learning engagement, time organization, content visit sequences, and activity participation patterns by applying statistical analysis, lag sequence analysis, and other data mining methods. This study examined the data of 535 learners taking the assessment in a MOOC to detect the differences in learning engagement and the above learning patterns amongst three groups of learners with different achievement levels, labeled failed, satisfactory and excellent. We found differences in both learning engagement and learning patterns among the three groups. The results indicated that for the learners to be successful, they require a certain degree of task completion as a basic guarantee for passing the course, effective session workload organization, reasonable learning content arrangement, and more cognitive engagement (rather than investing more time and energy). Based on the outcomes, implications for personalized instructional design and intervention to promote academic achievement in MOOCs are discussed.
Isolated CNS relapse of medullary aggressive high-grade B-cell lymphoma on 18F-FDG-PET/CT
Authors: Lambe Gerard , Doran Simon , Clifford Ruth , Nasoodi Afshin 
Published: May 2022

AbstractThis is a case of high-risk, aggressive, high-grade medullary B-cell lymphoma presenting with new onset of neurological dysfunction following initial complete response to the standard chemoimmunotherapy. A whole-body re-staging PET using fluorodeoxyglucose (18F-FDG) integrated with computed tomography (18FDG-PET/CT) performed with clinical suspicion of arachnoiditis, eloquently demonstrated unequivocal multifocal FDG uptake by the spinal cord without evidence of systemic recurrence, leading to a clinical diagnosis of secondary CNS lymphoma, which is a rare complication of DLBCL with ominous prognosis. Four cycles of Modified-MATRIX protocol resulted in a halt in fulminant course of the disease and the patient experienced slight reversal of the neurological deficits, although not deemed clinically fit for a repeat 18FDG-PET/CT due to his poor general well-being. Repeat MRI was suggestive of partial recovery, however. The clinical stability was proven short-lived, and the patient experienced progressive lower limb weakness only 3 weeks after discharge following his last cycle of treatment. Isolated CNS relapse of lymphoma is a rare occurrence in the literature. The CNS recurrence is more often leptomeningeal or confined to the brain parenchyma rather than the spinal cord. The role of 18FDG-PET/CT in the diagnostic algorithm of secondary CNS lymphoma is unclear and its significance in risk stratification and assessing the response to treatment has not been evaluated. This case report illustrates the imaging findings of a more unusual form of the disease with multifocal intramedullary involvement of the spinal cord, and highlights imaging features of this rare condition with 18FDG-PET/CT and MRI to support decision making in good clinical practice.
Validity and reliability of the Persian version of illness invalidation inventory (3*I) among patients with non-inflammatory rheumatic painful disorders
Authors: Ghavidel-Parsa Banafsheh , Khosousi Mohammad-Javad , Tohidi Sepehr , Bidari Ali , Soltani Saman , Zayeni Habib , Montazeri Ali 
Published: May 2022

Abstract
Background
The Invalidation Illness Inventory (3*I) is an instrument that assesses invalidation (including discounting and lack of understanding dimensions) experienced by patients with rheumatic disorders. This study aimed to translate and validate the 3*I in Iran.

Methods
Following translation of the 3*I into the Iranian language (Persian), a cross-sectional study was conducted. A consecutive sample of females with chronic non-inflammatory rheumatic painful diseases completed the questionnaire. Patients also completed the Revised Symptom Impact Questionnaire (SIQR) and the Short Form Health Survey-12 (SF-12). To examine convergent validity, the correlation between the 3*I, the SIQR, and the SF-12 was assessed. The reliability of the 3*I was examined by internal consistency (the Cronbach's alpha coefficient) and intraclass correlation coefficient (ICC).

Results
In all 196 patients participated in the study. The mean (SD) age of patients was 45.62 ± 10.70 years. Several significant correlations between the Invalidation Illness Inventory (discounting/lack of understanding) with the symptom impact (SIQR) and the short form health survey (SF-12) were observed lending support to the convergent validity of the 3*I. The Cronbach’s alpha coefficients were acceptable for most dimensions and sources, ranging from 0.52 to 0.88. Most ICC values for the dimensions of 3*I were above 0.75.

Conclusions
The findings indicated that the Persian version of Illness Invalidation Inventory (3*I) is a valid instrument for invalidation assessment in patients with chronic pain. Given the high frequency of perceived invalidation among patients with rheumatic painful disorders, serious attention is needed to the issue in clinical and research settings.
Impact of the fall armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), invasion on maize and the native Spodoptera litura (Fabricius) in East Java, Indonesia, and evaluation of the virulence of some indigenous entomopathogenic fungus isolates for controlling the pest
Authors: Afandhi Aminudin , Fernando Ito , Widjayanti Tita , Maulidi Agrintya Kurnia , Radifan Hirzi Ilman , Setiawan Yogo 
Published: May 2022

Abstract
Background
The fall armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), is an invasive alien species in Indonesia. This study aimed to assess the impact of its invasion in Indonesia by measuring the damaged area caused by the pest in maize fields located across East Java and simultaneously determine whether S. frugiperda outcompetes the native Asian armyworm Spodoptera litura (Fabricius). Secondly, the virulence of 14 entomopathogenic fungus (EPF) isolates against S. frugiperda larvae was evaluated in an effort to find effective biocontrol agent candidates.

Results
The damaged area caused by S. frugiperda was generally higher than that caused by S. litura during the survey period from August 2019 to December 2021. It indicated that S. frugiperda may have dominated the native armyworm and become the primary key pest of maize in Indonesia. Based on a single-concentration assay (106 conidia ml−1), the tested EPF isolates displayed varying degrees of virulence against S. frugiperda larvae, causing larval mortality of 3.5 to 71% at 10-day post-treatment, with the highest mortality rates provided by Beauveria bassiana sensu lato and Trichoderma asperellum sensu lato. At a concentration of 108 conidia ml−1, B. bassiana s.l. and T. asperellum s.l. elicited high larval mortality of 76 and 81%, respectively, at 10-day post-treatment. Nevertheless, the probit analysis based on a concentration–response assay revealed that T. asperellum s.l. had lower LC50 and LC90 values than B. bassiana s.l.

Conclusions
The attack and invasion of S. frugiperda seem to be a continual threat to the maize agro-ecosystem in Indonesia. As a consequence, Indonesia should mitigate and be well-prepared for future outbreaks of S. frugiperda. Indigenous EPF isolates used in this study may act as promising biocontrol agents of S. frugiperda, especially T. asperellum s.l. This study also serves as the first report documenting the direct lethality of Trichoderma fungus on S. frugiperda larvae.
Intracranial bleeding under vitamin K antagonists or direct oral anticoagulants: results of the RADOA registry
Authors: Pfeilschifter Waltraud , Lindhoff-Last Edelgard , Alhashim Ali , Zydek Barbara , Lindau Simone , Konstantinides Stavros , Grottke Oliver , Nowak-Göttl Ulrike , von Heymann Christian , Birschmann Ingvild , Beyer-Westendorf Jan , Meybohm Patrick , Greinacher Andreas , Herrmann Eva ,   the RADOA-Registry Investigators (Reversal Agent use in patients treated with Direct Oral Anticoagulants or vitamin K antagonists Registry)
Published: May 2022

Abstract
Background and purpose
The use of direct oral anticoagulants (DOAC) has increased sharply and DOAC are the oral anticoagulant therapy (OAT) of choice for the majority of patients with newly-diagnosed atrial fibrillation. Intracranial hemorrhage is the most severe adverse event of OAT. Systematic data on the course of intracranial hemorrhage under DOAC compared to vitamin K antagonists (VKA) are warranted to enable shared decision making in AF patients needing OAT.

Methods
This is a secondary analysis of the patients with intracranial bleedings from the prospective multicenter emergency department-based RADOA registry, which collected data on patients admitted with major bleeding while taking VKA or DOAC. The primary endpoint was in-hospital mortality until day 30. We evaluated hematoma volume and short-term clinical outcomes in relation to the extent of active OAT according to coagulation parameters and OAT plasma levels measured by UPLC-MS/MS.

Results
Of 193 patients with major bleeding, 109 (56.5%) had intracranial hemorrhage [52.3% intracerebral (ICH), 33.9% subdural (SDH), 11.0% subarachnoidal (SAH)]. 64 (58.7%) were on VKA and 45 (41.2%) were on DOAC. On admission, we could confirm active anticoagulation in 97.7% of VKA-treated patients based on either INR > 1.3 or phenprocoumon levels and in 75.8% of DOAC-treated patients based on DOAC levels. Patients suffering an intracranial hemorrhage under VKA showed significantly larger hematoma volumes and a higher in-hospital mortality. Especially in intracerebral hemorrhage, we observed a higher initial severity and numerically greater proportion of early changes towards palliative therapy under VKA, which coincided with a numerically higher case fatality.

Conclusions
We show significantly smaller hematoma volumes for ICH and SDH under DOAC in comparison to VKA and a significantly lower 30-day in-hospital mortality rate of DOAC-ICH, even before the introduction of specific antidotes. These data strongly support the use of DOAC whenever possible in patients requiring OAT.
Trial Registration: http://www.clinicaltrials.gov; Unique identifier: NCT01722786.
Modeling and assessment of five-frequency BDS precise point positioning
Authors: Wu Zhiyuan , Wang Qianxin , Hu Chao , Yu Zhihao , Wu Wei 
Published: May 2022

AbstractSince its full operation in 2020, BeiDou Satellite Navigation System (BDS) has provided global services with highly precise Positioning, Navigation, and Timing (PNT) as well as unique short-message communication. More and more academics focus on multi-frequency Precise Point Positioning (PPP) models, but few on BDS five-frequency PPP models. Therefore, this study using the uncombined and Ionospheric-Free (IF) observations develops five BDS five-frequency PPP models and compares them with the traditional dual-frequency model, known as Dual-frequency IF (DF) model. Some biases such as Inter-Frequency Biases (IFB) and Differential Code Bias (DCB) are also addressed. With the data collected from 20 stations, the BDS dual- and five-frequency PPP models are comprehensively evaluated in terms of the static and simulated kinematic positioning performances. Besides, the study also analyzes some by-product estimated parameters in five-frequency PPP models such as Zenith Troposphere Delay (ZTD). The results of experiment show that five-frequency PPP models have different levels of improvement compared with the DF model. In the static mode, the one single Five-Frequency IF combination (FF5) model has the best positioning consequent, especially in the up direction, and in the simulated kinematic mode, the Three Dual-frequency IF combinations (FF3) model has the largest improvement in convergence time.
Genetic Counselling: the biomedical bridge between molecular diagnosis and precision treatment
Authors: Banerjee Emili , Bhattacharjee Koutilya 
Published: May 2022

Abstract
Background
Since the development of genomics, we are able to understand backgrounds of differential pathogenicity of metabolic disorders. Molecular diagnosis has become inevitable for metabolic, neuro-psychiatric and genetic disorders due to highly overlapping pathophysiological symptoms. The present lacuna between clinical prescription and molecular diagnosis is very prominent and can only be filled up through experts who can function as the bridge in between.

Main body
In this present review, the authors tried to focus on the role of genetic counselors in disease diagnosis as well as scopes of disease biology in utilizing the expertise of genetic professional for precision treatments of patients. We summarized four major disease areas, Cancer management, Obstetrics and Gynecology, Newborn Screening and Rare Genetic Disorders, where molecular diagnosis and genetic counseling can highly support the clinicians in precision treatment of the patients. Idiopathic reproductive failures, clinically overlapping neuro-psychiatric disorders, chromosomal aberrations in progressing tumors, rare genetic disorders all the disease areas can find out fruitful intervention when enlightened with molecular diagnosis and genetic counseling. Though, genetic counseling is commonly practiced in intervening reproductive problems, newborn screening and cancer, still the scope of genetic counselor in successfully intervening multiple rare genetic diseases as well as common hereditary life style disorders, remain extremely high.

Conclusion
The liaison between clinicians and geneticists, specifically clinical prescription and genetic diagnosis is one of the key demands of present age, which can be successfully fulfilled by the genetic counselors. For these reasons, genetic counseling is predicted as the biomedical career of future due to being in the vital position for successful implementation of precision medicine.
Significance of metastamiR-10b in breast cancer therapeutics
Authors: Raval Apexa , Joshi Jigna , Shah Franky 
Published: May 2022

Abstract
Background
Breast cancer is a fatal disease and a major reason of cancer associated death in females. Many factors along with miRNA are responsible for the development and the progression of the disease. The miRNA plays a very crucial role in the regulation of the genes. MicroRNAs are of three major types—oncomiRs, tumor suppressive miRNAs, and metastamiRs.

Main body
MicoRNA-10b is a prometastatic microRNA targeting various genes that facilitates multiple outcomes such as metastasis, increased capacity for invasion, proliferation and migration, increased epithelial-mesenchymal transformation, angiogenesis, and therefore exhibits worse clinical outcomes. It is found to be upregulated in various malignancies and is thus to be considered as the possible therapeutic candidate.

Conclusion
The therapeutic delivery of miR-10b antagonists (antagomiRs) and/or knockdown of miRNA is beneficial in reducing tumor growth. Additionally, combination therapy which includes antisense oligonucleotides using miR-10b can function as an effective approach to tumor regression and drug resistance reversal.

Graphical abstract
Post-operative bronchoscopy findings of esophageal atresia patients, initial phase of single-institute experience
Authors: Hamed Dina Hossam El Dine , Hussein Ayman , Magdy Basma , Elseoudi Mohamed , Elbarbary Mohamed M. , Wishahy Ahmed M. K. 
Published: May 2022

Abstract
Background
Esophageal atresia (EA) is not a rare congenital anomaly. It is usually accompanied by tracheoesophageal fistula (TEF). Respiratory morbidities are experienced in most of the survivors. Although it was believed that these symptoms tend to improve by age, permanent lung damage may continue to adulthood in some patients. We aimed to assess the respiratory tract in the follow-up period as an attempt to correlate possible findings with symptoms experienced which allowed us to pay more attention to the respiratory tract during the upcoming surgical interventions. Prospective observational study was conducted on patients presented to our institute, throughout 2018, with various degrees of refractory respiratory tract involvement, after having had their EA repaired inside or outside our institute. After exclusion of esophageal causes of these manifestations, bronchoscopy was performed to correlate the findings with the symptoms experienced by these patients. The study does not include patients repaired after 2018 as surgical modifications were performed and are still under study.

Results
Fifteen patients presented with various respiratory symptoms. Although recurrent chest infection is the commonest presentation, acute life-threatening events were reported in 5 patients. Blind-ended tracheal diverticulum was the most common finding observed in 80% of patients. About 76% of these patients were found to have tracheomalacia. Moreover, bronchoscopy was able to detect recurrent tracheoesophageal fistula in 4 patients. Vocal cords were affected in 13% of these patients.

Conclusions
Frequent respiratory symptoms in operated patients warrant careful long-term monitoring and appropriate management. Although bronchoscopy is considered a mandatory pre-repair procedure, it is a crucial tool in evaluating the survivors. It is pivotal to pay more attention to the respiratory tract to modify the surgical techniques to overcome these pitfalls.
Classifying breast cancer in ultrahigh-resolution optical coherence tomography images using convolutional neural networks
Authors: Bareja Rohan , Mojahed Diana , Hibshoosh Hanina , Hendon Christine 
Published: May 2022

Optical coherence tomography (OCT) is being investigated in breast cancer diagnostics as a real-time histology evaluation tool. We present a customized deep convolutional neural network (CNN) for classification of breast tissues in OCT B-scans. Images of human breast samples from mastectomies and breast reductions were acquired using a custom ultrahigh-resolution OCT system with 2.72 µm axial resolution and 5.52 µm lateral resolution. The network achieved 96.7% accuracy, 92% sensitivity, and 99.7% specificity on a dataset of 23 patients. The usage of deep learning will be important for the practical integration of OCT into clinical practice.
A comprehensive analysis of the circRNA–miRNA–mRNA network in osteocyte-like cell associated with Mycobacterium leprae infection
Authors: Gao Zheng-Rong , Liu Qiong , Zhao Jie , Zhao Ya-Qiong , Tan Li , Zhang Shao-Hui , Zhou Ying-Hui , Chen Yun , Guo Yue , Feng Yun-Zhi 
Published: May 2022

Background
Bone formation and loss are the characteristic clinical manifestations of leprosy, but the mechanisms underlying the bone remodeling with Mycobacterium leprae (M. leprae) infection are unclear.

Methodology/Principal findings
Osteocytes may have a role through regulating the differentiation of osteogenic lineages. To investigate osteocyte-related mechanisms in leprosy, we treated osteocyte-like cell with N-glycosylated muramyl dipeptide (N.g MDP). RNA-seq analysis showed 724 differentially expressed messenger RNAs (mRNAs) and 724 differentially expressed circular RNA (circRNAs). Of these, we filtered through eight osteogenic-related differentially expressed genes, according to the characteristic of competing endogenous RNA, PubMed databases, and bioinformatic analysis, including TargetScan, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes. Based on these results, we built a circRNA–microRNA (miRNA)–mRNA triple network. Quantitative reverse-transcription polymerase chain reaction and western blots analyses confirmed decreased Clock expression in osteocyte-like cell, while increased in bone mesenchymal stem cells (BMSCs), implicating a crucial factor in osteogenic differentiation. Immunohistochemistry showed obviously increased expression of CLOCK protein in BMSCs and osteoblasts in N.g MDP–treated mice, but decreased expression in osteocytes.

Conclusions/Significance
This analytical method provided a basis for the relationship between N.g MDP and remodeling in osteocytes, and the circRNA–miRNA–mRNA triple network may offer a new target for leprosy therapeutics.