bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pengembangan Komoditas Unggulan Sub Sektor Hortikultura Di Kabupaten Konawe
Authors: Angreini Nurlina , Rahim Manat , Salam Idrus 
Published: January 2022

Komuditas unggulan pada suatu wilayah perlu untuk ditingkatkan. Penelitian ini bertujuan (1) mengetahui komoditas basis di Kabupaten Konawe, (2) mengetahui ketersediaan lahan untuk pengembangan komoditas unggulan subsektor hortikultura, (3) mendapatkan informasi tentang kelayakan usahatani komoditas unggulan, dan (4) mengetahui strategi pengembangan komoditas unggulan sub sektor hortikultura di Kabupaten Konawe. Metode yang digunakan yaitu (1) Loqation Question (LQ) dan Dinamyc Location Question (DLQ), (2) analisis spasial, (3) R/C ratio, dan (4) SWOT. Hasil penelitian yaitu (1) cabai rawit merupakan komoditi unggulan nasional subsektor hortikultura dengan nilai LQ dan DLQ rata-rata tahun 2015-2019 yakni 1,35 dan 7,69 dengan kriteria basis dan berpotensi untuk dikembangkan, (2) potensi lahan yang tersedia seluas 2901,59 ha atau 46,19 %, (3) Usahatani cabai rawit di Kabupaten Konawe juga layak untuk dikembangkan dengan nilai kelayakan R/C ratio yakni 2,40, (4) Strategi pengembangan komoditas unggulan dapat dilakukan dengan perluasan lahan dan areal tanam komoditas unggulan, peningkatan kemandirian petani melalui pembinaan dan penyuluhan, pemanfaatan keterampilan dan pengalaman petani dalam meningkatkan produksi yang berkualitas, bersaing di pasaran serta dapat memenuhi kebutuhan dan permintaan konsumen, serta pengembangan kawasan komoditas unggulan berdasarkan potensi wilayah. Kata Kunci : holtikultura, komuditas unggulan, pengembangan
Dampak Pelabuhan Bungkutoko Terhadap Kondisi Sosial Ekonomi Masyarakat Dikawasan Pelabuhan
Authors: Hardianti Hardianti , Widayati Weka , Muh. Magribi La ode 
Published: January 2022

Abstrach: The purpose of this study is to (1) analyze the differences in the socio- economic conditions of the community before and after the existence of Bungkutoko Port, (2) Mapping the existence of Bungkutoko Port. The population in this study were 552 households in Bungkutoko Village. The sample of this research is 85 people in Bungkutoko Village. The results showed (1) There are differences in the socio-economic conditions of the community before and after the Bungkutoko Port. The existence of Bungkutoko Port has a positive impact on the socio-economic conditions of the community, which creates job opportunities, increases community income and improves environmental security. But on the other hand, Bungkutoko Port has not had a positive impact on education and public health. (2) Bungkutoko Port is in the administrative area of Bungkutoko Village, Nambo District, Kendari City. The existence of Bungkutoko Port not only has an impact on the socio-economic conditions of the community, but also has an impact on infrastructure development in the local area.Keywords: Bungkutoko Port; Public; Socio-Economic ConditionKeberadaan Pelabuhan Bungkutoko mempunyai dampak ikutan sehingga perlu untuk dilakukan penelitian. Tujuan penelitian ini untuk (1) Menganalisis perbedaan kondisi sosial ekonomi masyarakat sebelum dan setelah adanya Pelabuhan Bungkutoko, (2) Memetakan keberadaan Pelabuhan Bungkutoko. Populasi dalam penelitian ini adalah masyarakat di Kelurahan Bungkutoko berjumlah 552 kepala keluarga. Sampel penelitian ini adalah masyarakat di Kelurahan Bungkutoko berjumlah 85 kepala keluarga. Hasil penelitian menunjukkan (1) Terdapat perbedaan kondisi sosial ekonomi masyarakat sebelum dan setelah adanya Pelabuhan Bungkutoko. Keberadaan Pelabuhan Bungkutoko berdampak positif terhadap kondisi sosial ekonomi masyarakat, dimana terciptanya kesempatan kerja, peningkatan pendapatan masyarakat dan peningkatan keamanan lingkungan. Tetapi disisi lain, Pelabuhan Bungkutoko belum memberikan dampak positif bagi pendidikan dan kesehatan masyarakat. (2) Pelabuhan Bungkutoko berada diwilayah administrasi Kelurahan Bungkutoko Kecamatan Nambo Kota Kendari. Keberadaan Pelabuhan Bungkutoko tidak hanya berdampak terhadap kondisi sosial ekonomi masyarakat, tetapi juga berdampak pada pengembangan infrastruktur diwilayah setempat. Kata Kunci: Pelabuhan Bungkutoko; Masyarakat; Kondisi Sosial Ekonomi
Interview with Milla Cozart Riggio, Angela Marino, and Paolo Vignolo
Authors: Allen Emily Ruth 
Published: January 2022

Emily Ruth Allen interviews Milla Cozart Riggio, Angela Marino, and Paolo Vignolo on Festive Devils of the Americas (2015). Interview date: Feb 4, 2021
Milla Cozart Riggio is James J. Goodwin Professor of English Emerita at Trinity College. Angela Marino is Associate Professor in the Department of Theater, Dance, and Performance Studies at the University of California Berkeley. Paolo Vignolo is Associate Professor of History at the National University of Colombia, Bogota
Interview with Rebecca Hope Dirksen
Authors: Machado Isabel 
Published: January 2022

Isabel Machado interviews Rebecca Hope Dirksen on After the Dance, the Drums Are Heavy: Carnival, Politics, and Musical Engagement in Haiti (2020). Interview date: Mar 17, 2021
Dr. Rebecca Dirksen is an ethnomusicologist working across the spectrum of musical genres in Haiti and its diaspora. Her research concerns cultural approaches to development, crisis, and disaster; sacred ecologies, diverse environmentalisms, and ecomusicology; and applied/engaged/activist scholarship. She is a professor in the Department of Folklore and Ethnomusicology at Indiana University Bloomington and a founding member of the Diverse Environmentalisms Research Team (DERT).
Dropouts From Sublingual Immunotherapy and the Transition to Subcutaneous Immunotherapy in House Dust Mite-Sensitized Allergic Rhinitis Patients
Authors: Chen Huan , Gong Guo-qing , Ding Mei , Dong Xiang , Sun Yuan-li , Wan Lang , Gao Ya-dong 
Published: January 2022

Purpose: Both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) are effective in reducing symptoms and medication scores and inducing long-term efficacy in patients with allergic rhinitis (AR). However, SLIT has been associated with poor patient adherence. This study investigates the factors impacting dropout rates from SLIT in house dust mite (HDM)-sensitized AR patients.Methods: A retrospective study was performed to analyze dropout rates and reasons in AR patients receiving Dermatophagoides farinae (Der f) SLIT with a follow-up period of 2 years.Results: A total of 719 HDM-sensitized AR patients received Der f-SLIT. Dropout rates increased with time and most occurred after 1 year of SLIT. By month 24, 654 (91%) patients had discontinued SLIT. The dropout rates by month 24 were 100, 90.1, and 91.1% in children &lt;5 years old, children aged 5–18 years old, and adults ≥ 18 years old, respectively. Combination with allergic asthma and mono- or multi-sensitization to other aeroallergens did not affect the dropout rates. The most common self-reported reasons for dropouts were refusal of continuation, dissatisfaction with the efficacy, transition to SCIT, and adverse effects. Refusal of continuation increased with age, whereas transition to SCIT decreased with age. Ninety-seven cases transitioned from SLIT to SCIT, and the transition rates increased with time. Comorbid allergic asthma did not affect the transition rates. However, multi-sensitization was associated with a slightly higher rate of transition to SCIT. The most common reason for the transition was dissatisfaction with the efficacy (54.6%), which was only reported by patients older than 5 years. For children who began SLIT at younger than 5 years old, the most common reason (81.2%) for transition was age reaching 5 years.Conclusions: HDM-SLIT has a very high dropout rate, which is mainly due to refusal of continuation and dissatisfaction with the efficacy. Transitioning from SLIT to SCIT may help keep these patients on AIT and thus increase adherence and long-term efficacy.
Discovery of Polyoxypregnane Derivatives From Aspidopterys obcordata With Their Potential Antitumor Activity
Authors: Guo Hong-Wei , Tian Yun-Gang , Liu Yi-Han , Huang Jia , Wang Jian-Xia , Long Hua , Wei Hua 
Published: January 2022

The bioassay-guided phytochemical study of an ethnic medicinal plant Aspidopterys obcorda ta Hemsl. var. obcordata results in the isolation of eight new polyoxypregnane derivatives, named aspidatasides A–H (1–8), along with ten known analogs (9–18). The series polyoxypregnane derivatives were screened for their cytoxic activity against HL-60 cells, and compound 2 showed the highest potency with an IC50 8.03 μM. Preliminary structure–activity relationship studies displayed that the sugar chain and double bond could notably impact their biological activity.
Application of mNGS in the Etiological Diagnosis of Thoracic and Abdominal Infection in Patients With End-Stage Liver Disease
Authors: Chen Hongmei , Zhang Ye , Zheng Jie , Shi Lei , He Yingli , Niu Yinghua , Lei Jine , Zhao Yingren , Xia Han , Chen Tianyan 
Published: January 2022

BackgroundDespite the obvious advantages of metagenomic next-generation sequencing (mNGS) in etiological diagnosis of various infectious diseases, there are few reports on etiological diagnosis of suspected thoracic and abdominal infections in patients with end-stage liver disease (ESLD).MethodsSeventy-three ESLD patients were enrolled from January 2019 to May 2021 due to suspected complicated thoracic and abdominal infections with poor response to empirical anti-infective treatment. Pleural effusion and ascites samples of these patients were collected for mNGS detection and conventional pathogen culture. The application value of mNGS in etiological diagnosis of thoracic and abdominal infections in ESLD patients was finally evaluated.ResultsA total of 96 pathogens were detected using mNGS method, including 47 bacteria, 32 viruses, 14 fungi, 2 Mycobacterium tuberculosis, and 1 parasite. The positive rate of mNGS reached 42.5%, which was significantly higher than that of conventional culture method (21.9%) (p = 0.008). Considering neutrophil counts, the overall positive rate of bacteria detection of both methods in Polymorphonuclear Neutrophils (PMN) ≥250/mm3 group was 64.3% and in PMN &lt;250/mm3 group was 23.7%. Compared with the final clinical diagnosis, the agreement rate of mNGS in patients with positive bacteria detection and with suspected positive bacteria detection was 78.6% (11/14) and 44.4% (8/18), respectively. In addition, the agreement rate of mNGS was 66.7% (4/6, respectively) in patients with positive and suspected fungal detection. Interestingly, of the 11 patients with fungal detection, 5 had alcoholic liver disease, accounting for 45.5% of all patients with alcoholic liver disease. We also detected 32 strains of viruses using mNGS, mainly cytomegalovirus (62.5%).ConclusionsThe mNGS method is a useful supplement to conventional culture methods, which performs a higher positive rate, higher sensitivity, and broader pathogen spectrum, especially for rare pathogens and those difficult to culture. For ESLD patients, mNGS has great prospects in early etiological diagnosis of thoracic and abdominal infections. In addition, the cutoff values for the diagnosis of bacterial infection (PMN ≥250/mm3) in the thoracic and abdominal cavities may need to be redefined.
Cardiorespiratory Responses During High-Intensity Interval Training Prescribed by Rating of Perceived Exertion in Patients After Myocardial Infarction Enrolled in Early Outpatient Cardiac Rehabilitation
Authors: Dun Yaoshan , Hammer Shane M. , Smith Joshua R. , MacGillivray Mary C. , Simmons Benjamin S. , Squires Ray W. , Liu Suixin , Olson Thomas P. 
Published: January 2022

Objective: We aimed to determine the cardiorespiratory responses during, and adaptations to, high-intensity interval training (HIIT) prescribed using ratings of perceived exertion (RPE) in patients after myocardial infarction (MI) during early outpatient cardiac rehabilitation (CR).Methods: We prospectively recruited 29 MI patients after percutaneous coronary intervention who began CR within 2 weeks after hospital discharge. Eleven patients (seven men; four women; age: 61 ± 11 yrs) who completed ≥24 supervised HIIT sessions with metabolic gas exchange measured during HIIT once weekly for 8 weeks and performed pre- and post- CR cardiopulmonary exercise tests were included in the study. Each HIIT session consisted of 5–8 high-intensity intervals [HIIs, 1-min RPE 14–17 (Borg 6–20 scale)] and low-intensity intervals (LIIs, 4-min RPE &lt; 12). Metabolic gas exchange, heart rate (HR), and blood pressure during HIIT were measured.Results: The mean oxygen uptake (V˙O2) during HIIs across 88 sessions of HIITs [91 (14)% of V˙O2peak, median (interquartile range, IQR)] was significantly higher than the lower limit of target V˙O2 zone (75% of V˙O2peak) recommended for the HII (p &lt; 0.001). Exercise intensity during RPE-prescribed HIITs, determined as %V˙O2peak, was highly repeatable with intra-class correlations of 0.95 (95% CI 0.86– 0.99, p &lt; 0.001). For cardiorespiratory adaptations from the first to the last session of HIIT, treadmill speed, treadmill grade, treadmill power, V˙O2HII, %V˙O2peak, and VE during HIIs were increased (all p &lt; 0.05), while no difference was found for HR, %HRpeak and systolic blood pressure (all p &gt; 0.05). V˙O2peak increased by an average of 9% from pre-CR to post-CR. No adverse events occurred.Conclusion: Our results demonstrate that HIIT can be effectively prescribed using RPE in MI patients during early outpatient CR. Participation in RPE-prescribed HIIT increases exercise workload and V˙O2 during exercise training without increased perception of effort or excessive increases in heart rate or blood pressure.
MiR-27a-3p Targets GLP1R to Regulate Differentiation, Autophagy, and Release of Inflammatory Factors in Pre-Osteoblasts via the AMPK Signaling Pathway
Authors: Zeng Zhi , Fei Liangyu , Yang Juntao , Zuo Jun , Huang Zelin , Li Hao 
Published: January 2022

Objective: Osteoporosis is caused by the dysregulation of bone homeostasis which is synergistically mediated by osteoclasts and osteoblasts. MiR-27a-3p is a key inhibitor of bone formation. Hence, unearthing the downstream target gene of miR-27a-3p is of great significance to understand the molecular mechanism of osteoporosis.Methods: Bioinformatics analysis was utilized to find the downstream target gene of miR-27a-3p, and dual-luciferase reporter assay was conducted to validate the interplay of miR-27a-3p and GLP1R. Besides, qRT-PCR, Western blot, and enzyme-linked immunosorbent assay (ELISA) were employed to verify the impact of miR-27a-3p on GLP1R expression and the differentiation, autophagy, and inflammatory response of MC3T3-E1 pre-osteoblasts.Results: Dual-luciferase assay validated that miR-27a-3p directly targeted GLP1R. Additionally, posttreatment of MC3T3-E1 cells with miR-27a-3p mimics resulted in a remarkable decrease in expression levels of GLP1R, cell differentiation marker gene, autophagy marker gene, and AMPK. These results indicated that miR-27a-3p targeted GLP1R to inhibit AMPK signal activation and pre-osteoblast differentiation and autophagy, while promoting the release of inflammatory factors.Conclusion: The miR-27a-3p/GLP1R regulatory axis in pre-osteoblasts contributes to understanding the molecular mechanism of osteoporosis.
The Anti-Inflammatory and Uric Acid Lowering Effects of Si-Miao-San on Gout
Authors: Cao Ling , Zhao Tianyi , Xue Yu , Xue Luan , Chen Yueying , Quan Feng , Xiao Yu , Wan Weiguo , Han Man , Jiang Quan , Lu Liwei , Zou Hejian , Zhu Xiaoxia 
Published: January 2022

BackgroundSi-Miao-San (SMS) is a well-known traditional Chinese medicine. This study aims to evaluate the anti-inflammatory effects of SMS on gouty arthritis and its potential mechanism of action.MethodsThe effects and mechanism of SMS were evaluated in monosodium urate (MSU)-treated mice or macrophages. The expression of cytokines and PI3K/Akt was analyzed using real-time PCR and Western blotting analyses. Macrophage polarization was assessed with immunofluorescence assays, real-time PCR, and Western blotting. Mass spectrometry was used to screen the active ingredients of SMS.ResultsPretreatment with SMS ameliorated MSU-induced acute gouty arthritis in mice with increased PI3K/Akt activation and M2 macrophage polarization in the joint tissues. In vitro, SMS treatment significantly inhibited MSU-triggered inflammatory response, increased p-Akt and Arg-1 expression in macrophages, and promoted M2 macrophage polarization. These effects of SMS were inhibited when PI3K/Akt activation was blocked by LY294002 in the macrophages. Moreover, SMS significantly reduced serum uric acid levels in the hyperuricemia mice. Using mass spectrometry, the plant hormones ecdysone and estrone were detected as the potentially effective ingredients of SMS.ConclusionSMS ameliorated MSU-induced gouty arthritis and inhibited hyperuricemia. The anti-inflammatory mechanism of SMS may exert anti-inflammatory effects by promoting M2 polarization via PI3K/Akt signaling. Ecdysone and estrone might be the potentially effective ingredients of SMS. This research may provide evidence for the application of SMS in the treatment of gout.
The Efficacy of Denosumab in Patients With Rheumatoid Arthritis: A Systematic Review and Pooled Analysis of Randomized or Matched Data
Authors: Hu Qiongwen , Zhong Xue , Tian Hua , Liao Pu 
Published: January 2022

ObjectiveThe purpose of this study was to evaluate the efficacy of denosumab treatment in patients with rheumatoid arthritis (RA).MethodsThe Medline, Embase and Cochrane Library databases were searched for relevant clinical studies. Studies that assessed the efficacy of denosumab in patients with RA were identified. The primary endpoints were the percent changes in bone mineral density (BMD), and the changes in modified total Sharp score (mTSS), modified Sharp erosion score and joint space narrowing (JSN) score. Pooled analyses were calculated using random-effect models.ResultsAfter searching the literature and performing further detailed assessments, 10 studies with a total of 1758 patients were included in the quantitative analysis. Pooled analyses showed that denosumab treatment significantly increased the percent changes in lumbar spine BMD [mean difference (MD): 5.12, confidence intervals (CI): 4.15 to 6.09], total hip BMD (MD: 2.72, 95% CI: 1.80 to 3.64) and femoral neck BMD (MD: 2.20, 95% CI: 0.94 to 3.46) compared with controls. Moreover, denosumab treatment significantly decreased the changes in mTSS (MD: -0.63, 95% CI: -0.86 to -0.41) and modified Sharp erosion score (MD: -0.62, 95% CI: -0.88 to -0.35). Subgroup analysis indicated that denosumab was superior to bisphosphonates for the improvement of BMD and the mitigation of joint destruction.ConclusionDenosumab treatment was associated with increased BMD and alleviated progression of joint destruction in RA patients, even when compared with bisphosphonates.
Microstructure and Mechanical Properties of Aluminum Alloy/Stainless Steel Dissimilar Ring Joint Welded by Inertia Friction Welding
Authors: Qin Feng , Zhang Chunbo , Zhou Jun , Xu Kai , Wang Qi , Li Yunlei , Zhang Wenhan 
Published: January 2022

In recent years, studying the weldability of a dissimilar metal hybrid structure, with the potential to make full use of their unique benefits, has been a research hotspot. In this article, inertia friction welding was utilized to join Φ130 forged ring of 2219 aluminum alloy with 304 stainless steel. Optical observation (OM), electron back scattering diffraction (EBSD), and scanning electron microscopy (SEM) were utilized to examine the joint microstructure in depth. Depending on the research, a significant thermal–mechanical coupling effect occurs during welding, resulting in inadequate recrystallization on aluminum-side thermo-mechanically affected zone (TMAZ) and forming zonal features. The crystal orientation and grain size of each TMAZ region reflect distinct differences. On the joint faying surface, the growth of intermetallic compounds (IMCs) is inhibited by a fast cooling rate and metallurgical bonding characteristics were found depending on the discontinuous distribution of IMCs. The average joint tensile strength can reach 161.3 MPa achieving 92.2% of 2219-O; fracture occurs on aluminum-side base metal presenting ductile fracture characteristics.
Antibiotic Resistance and Molecular Biological Characteristics of Non-13-Valent-Pneumococcal Conjugate Vaccine Serogroup 15 Streptococcus pneumoniae Isolated From Children in China
Authors: Shi Wei , Du Qianqian , Yuan Lin , Gao Wei , Wang Qing , Yao Kaihu 
Published: January 2022

Background: The isolation rate of serogroup 15 Streptococcus pneumoniae has been increasing since developing countries began administering the 13-valent pneumococcal conjugate vaccine.Methods: We detected the antibiotic resistance and molecular characteristics of 126 serogroup 15 S. pneumoniae strains isolated from children in China. Serotypes were determined via the Quellung reaction. Antibiotic resistance was tested using the E-test or disc diffusion method. Sequence types were assigned via multilocus sequence typing. Data were analyzed using WHONET 5.6 software.Results: The frequencies of S. pneumoniae serotypes 15A, 15B, 15C, and 15F were 29.37, 40.48, 28.57, and 1.59%, respectively. Continuous-monitoring data from Beijing showed that the annual isolation rates of serogroup 15 S. pneumoniae were 7.64, 7.17, 2.58, 4.35, 3.85, 7.41, and 10.53%, respectively, from 2013 to 2019. All 126 serogroup 15 strains were susceptible to vancomycin and ceftriaxone. The non-susceptibility rate to penicillin was 78.57%. All strains were resistant to erythromycin with high minimum inhibitory concentrations (MICs). The multidrug resistance rate was 78.57%. The most common clonal complexes were CC3397, CC6011, CC10088, CC9785, and ST8589.Conclusion: Serogroup 15 S. pneumoniae is common among children in China, and these strains should be continuously monitored.
Development and Verification of a Hypoxic Gene Signature for Predicting Prognosis, Immune Microenvironment, and Chemosensitivity for Osteosarcoma
Authors: Wu Fengfeng , Xu Juntao , Jin Mingchao , Jiang Xuesheng , Li Jianyou , Li Xiongfeng , Chen Zhuo , Nie Jiangbo , Meng Zhipeng , Wang Guorong 
Published: January 2022

Objective: Hypoxic tumors contribute to local failure and distant metastases. Nevertheless, the molecular hallmarks of hypoxia remain ill-defined in osteosarcoma. Here, we developed a hypoxic gene signature in osteosarcoma prognoses.Methods: With the random survival forest algorithm, a prognostic hypoxia-related gene signature was constructed for osteosarcoma in the TARGET cohort. Overall survival (OS) analysis, receiver operating characteristic (ROC) curve, multivariate cox regression analysis, and subgroup analysis were utilized for assessing the predictive efficacy of this signature. Also, external validation was presented in the GSE21257 cohort. GSEA was applied for signaling pathways involved in the high- and low-risk samples. Correlation analyses between risk score and immune cells, stromal/immune score, immune checkpoints, and sensitivity of chemotherapy drugs were performed in osteosarcoma. Then, a nomogram was built by integrating risk score, age, and gender.Results: A five-hypoxic gene signature was developed for predicting survival outcomes of osteosarcoma patients. ROC curves confirmed that this signature possessed the well predictive performance on osteosarcoma prognosis. Furthermore, it could be independently predictive of prognosis. Metabolism of xenobiotics by cytochrome P450 and nitrogen metabolism were activated in the high-risk samples while cell adhesion molecules cams and intestinal immune network for IgA production were enriched in the low-risk samples. The low-risk samples were characterized by elevated immune cell infiltrations, stromal/immune scores, TNFRSF4 expression, and sensitivity to cisplatin. The nomogram accurately predicted 1-, 3-, and 5-years survival duration.Conclusion: These findings might offer an insight into the optimization of prognosis risk stratification and individualized therapy for osteosarcoma patients.