bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic versus robotic adrenalectomy in pheochromocytoma patients
Authors: Isiktas Gizem , Nazli Avci Seyma , Ergun Onuralp , Krishnamurthy Vikram , Jin Judy , Siperstein Allan , Berber Eren 
Published: May 2022

AbstractBackground and ObjectivesPheochromocytoma is a challenging tumor type requiring resection with a clear margin and an intact capsule to prevent recurrences. Our aim was to compare perioperative outcomes of laparoscopic adrenalectomy (LA) versus robotic adrenalectomy (RA) for pheochromocytoma.MethodsIn an institutional review board‐approved retrospective study, clinical parameters of patients who underwent LA versus RA at a single center were compared using Mann–Whitney U, χ2, and survival analyses. Continuous data are expressed as median (interquartile range).ResultsThere was a total of 157 patients (RA: n = 87, LA: n = 70) analyzed. Estimated blood loss (36.3 [35.0] vs. 99.9 [65.0] cc, p = 0.020) and hospital stay (1.3 [0.0] vs. 2.2 [1.0] days, p = 0.010) were lower in robotic versus laparoscopic group, respectively. Disease‐free and overall survival was similar between groups. The rate of conversion to open for tumors ≥5 cm was less in the robotic group (0% vs. 14%, respectively, p = 0.048).ConclusionIn this study, long‐term outcomes of LA and RA were similar, although adrenalectomies performed robotically were associated with less blood loss, shorter hospital stay, and a lower chance of conversion to open in the case of large tumors.
Macroscopic Extranodal Extension In Oral Squamous Cell Carcinoma‐A Subgroup With Poor Survival
Authors: Joshi Kiran , Agarwal Mudit , Pasricha Sunil , Singh Abhishek , Garg Sunil , Rai Shreya , Tandon Sarthak 
Published: May 2022

BackgroundOral cancer portends a significant cause of morbidity and mortality worldwide. Cervical lymph node metastasis with extranodal extension (ENE) is associated with a poor prognosis. There has been accumulating evidence regarding the extent of ENE to be associated with prognosis and survival.AimThis observational study was performed to analyze the prognostic implication of macroscopic and microscopic ENE in metastatic cervical lymph nodes of oral cavity cancer patients.MethodsA total of 92 oral cavity cancer patients with pathologically detected ENE were included in this study. Both the groups (macroscopic and microscopic ENE) were compared in terms of overall survival and disease‐free survival by using Kaplan –Meier. The pattern of failure was determined by Fischer's exact test. Univariate and multivariate analyses were calculated to determine the significant risk factors of death.ResultsThe 2 years of disease‐free survival and overall survival rates for the whole cohort were 51.2% and 53.9% respectively. The 2‐year survival rate for the microscopic group (≤2 mm) and macroscopic (>2 mm) was 72.6% and 0% respectively, while the distal failure rate in microscopic ENE group and macroscopic ENE group was 22.22% and 44.83% respectively (p‐value = 0.026).ConclusionsMacroscopic ENE (>2 mm) in oral cavity squamous cell cancer represents an aggressive entity with early regional and distant failure as compared to microscopic ENE (≤2 mm). Thus, macroscopic ENE (>2 mm) warrants a distinct subgroup with special consideration for intensification of treatment.Level of Evidence3 Laryngoscope, 133:588–593, 2023
Effect of Sleep Surgery on Inflammatory Cytokines in Adult Obstructive Sleep Apnea: A Systematic Review and Meta‐Analysis
Authors: Lee Chia‐Hsuan , Hsu Wei‐Chung , Yeh Te‐Huei , Ko Jenq‐Yuh , Lin Ming‐Tzer , Kang Kun‐Tai 
Published: May 2022

ObjectiveTo evaluate whether sleep surgery is associated with inflammatory cytokine changes. This study hypothesizes cytokines may change after surgery in adult obstructive sleep apnea (OSA).Study DesignSystematic review and meta‐analysis.MethodsThe study protocol was registered on PROSPERO (CRD42020154425). Two authors independently searched PubMed, Embase, and Cochrane review databases from their inception to June 2021. The keywords used were sleep apnea, inflammatory markers, cytokines, and surgery. The effects of sleep surgery on the apnea–hypopnea index (AHI) and inflammatory cytokines were evaluated using a random‐effects model. Both mean difference (MD) and standardized mean difference (SMD) of the changes in cytokines were calculated.ResultsNine studies with 235 adults were included (mean age: 43 years; 82% were men). After sleep surgery, AHI significantly reduced by −11.3 events/h (95% confidence interval [CI], −15.8 to −6.9). In total, 8 and 6 studies were pooled for examining tumor necrosis factor‐alpha (TNF‐α) and interleukin‐6 (IL‐6) levels, respectively. Sleep surgery significantly reduced TNF‐α levels, with an MD of −2.8 pg/ml (95% CI, −5.1 to −0.6) and an SMD of −0.56 (95% CI, −0.85 to −0.27). Furthermore, sleep surgery reduced IL‐6 levels, with an MD of −0.6 pg/ml (95% CI, −1.0 to −0.2) and an SMD of −0.66 (95% CI, −0.89 to −0.43). No covariates were identified to be correlated with cytokine changes in subgroup and meta‐regression analyses. Funnel plots showed possible publication bias in current data.ConclusionsIn adults, OSA treatment with sleep surgery improves inflammatory cytokines. Laryngoscope, 132:2275–2284, 2022
Contribution of Verbal Learning & Memory and Spectro‐Temporal Discrimination to Speech Recognition in Cochlear Implant Users
Authors: Harris Michael S. , Hamel Benjamin L. , Wichert Kristin , Kozlowski Kristin , Mleziva Sarah , Ray Christin , Pisoni David B. , Kronenberger William G. , Moberly Aaron C. 
Published: May 2022

ObjectivesExisting cochlear implant (CI) outcomes research demonstrates a high degree of variability in device effectiveness among experienced CI users. Increasing evidence suggests that verbal learning and memory (VL&M) may have an influence on speech recognition with CIs. This study examined the relations in CI users between visual measures of VL&M and speech recognition in a series of models that also incorporated spectro‐temporal discrimination. Predictions were that (1) speech recognition would be associated with VL&M abilities and (2) VL&M would contribute to speech recognition outcomes above and beyond spectro‐temporal discrimination in multivariable models of speech recognition.MethodsThis cross‐sectional study included 30 adult postlingually deaf experienced CI users who completed a nonauditory visual version of the California Verbal Learning Test‐Second Edition (v‐CVLT‐II) to assess VL&M, and the Spectral‐Temporally Modulated Ripple Test (SMRT), an auditory measure of spectro‐temporal processing. Participants also completed a battery of word and sentence recognition tasks.ResultsCI users showed significant correlations between some v‐CVLT‐II measures (short‐delay free‐ and cued‐recall, retroactive interference, and “subjective” organizational recall strategies) and speech recognition measures. Performance on the SMRT was correlated with all speech recognition measures. Hierarchical multivariable linear regression analyses showed that SMRT performance accounted for a significant degree of speech recognition outcome variance. Moreover, for all speech recognition measures, VL&M scores contributed independently in addition to SMRT.ConclusionMeasures of spectro‐temporal discrimination and VL&M were associated with speech recognition in CI users. After accounting for spectro‐temporal discrimination, VL&M contributed independently to performance on measures of speech recognition for words and sentences produced by single and multiple talkers.Level of Evidence3 Laryngoscope, 133:661–669, 2023
Factors Shifting Preference Toward Telemedicine in the Delivery of Skin Cancer Reconstruction Care
Authors: Du Eric Y. , Moody Rylee A. , Simpson Matthew C. , Nellore Aditya , Sinnwell Joseph G. , Heiland Luke D. , Grace Shane A. , Chen Collin L. 
Published: May 2022

ObjectivesIdentify which delivery modality for skin reconstruction care, face‐to‐face (FTF) in‐person versus two telemedicine modalities, store‐and‐forward (S&F) and live video chat (LVC), is patient preferred and how cost, access, wait time, and demographics influence this preference.Study DesignCross‐sectional survey.MethodsA 16‐question survey querying demographics and five scenario‐specific preferences questions for the delivery of skin cancer reconstruction care was created and distributed via Amazon Mechanical Turk (MTurk), a crowdsourcing online marketplace, and in‐person to Mohs micrographic surgery patients.Results1394 MTurk and 55 in‐person responses were included. While 82.1% of online respondents prefer FTF clinic visits, this decreases to 58.3% with an in‐person visit cost (p < 0.01) and furthermore to a minority 43.5% with both an in‐person visit cost and wait time (p < 0.01) despite 77.8% believing that usefulness to the surgeon would improve FTF. Both the MTurk and in‐person cohorts demonstrated similar response patterns despite considerable demographic differences. Multivariable analyses revealed that telemedicine was preferred by MTurk respondents with Medicaid (adjusted OR [95% CI]: 1.97 [1.18–3.31]) or Medicare (1.69 [1.10–2.59]) versus private insurance, and prior skin cancer (2.01 [1.18–3.42]) and less preferred by those earning $140,000+ per year (0.49 [0.29–0.82]) compared to those earning <$20,000 per year.ConclusionsFTF visits are preferred for skin cancer reconstruction care; this shifts toward virtual care with a cost and wait time in spite of the perceived quality of care. Individuals with socioeconomic barriers to access prefer telemedicine. MTurk can be a valuable tool for behavioral research in FPRS.Level of EvidenceNA Laryngoscope, 133:294–301, 2023
The role of pulses in improving human health: A review
Authors: Didinger Chelsea , Thompson Henry J. 
Published: May 2022

AbstractPublic health concerns are discussed so frequently that it is beginning to cause desensitization. And yet, rates of chronic disease remain alarmingly high worldwide—or are even increasing. Primary prevention is essential to reverse these trends. Indeed, the sustainable implementation of good health practices can promote human physical and psychological well‐being while simultaneously being more cost‐effective than the treatment of chronic disease. A healthy dietary pattern is a cornerstone of primary prevention. Pulses, or the dry seeds of non‐oilseed legumes (e.g., chickpeas, cowpeas, dry beans, dry peas, and lentils)—also called grain legumes—are widely recognized as a nutrient‐dense food and one of the richest sources of dietary fiber and plant protein. Combined with their affordable price point and contributions to sustainable food systems, they can be considered a prime example of a superfood. Historically, they also have a rich culinary history around the world, making them culturally relevant to many cuisines and cultures. The scientific literature supports the role of pulses in many health benefits, yet the quality of the evidence is often low. In this review, we explore the findings—and limitations—of research to date and conclude with suggestions for moving the field forward to investigate and establish robust support for a recommended serving size that is most beneficial for human health.
Waterborne polyurethane‐acrylate‐polyaniline: Interfacial hydrogen bonding for enhancing the antistatic, damping, and mechanical properties
Authors: Liang Xiaobo , Deng Yunjiao , Li Songsong , Wu Jingtao , Zhang Huixuan , Zhang Zijian 
Published: May 2022

AbstractDamping coatings can convert kinetic energy into other forms of energy for consumption and have been widely used for vibration and noise reduction in rail trains, aerospace, automobile industry, and other fields. However, many aspects of damping coating such as, damping, water resistance, heat resistance, mechanical properties and antistatic properties require further improvement. In this study, a low‐cost conductive polyaniline (PANI) with a simple preparation method was dispersed in N‐methyl pyrrolidone and added to waterborne polyurethane‐acrylate (WPUA) hybrid latexes. The interfacial hydrogen bonding increases the interaction force between molecular chains, effectively improve the water resistance, heat resistance, damping, and mechanical properties of WPUA, and endowed WPUA with antistatic properties. Among them, PANI was used as an antistatic medium to be synthesized by chemical oxidation and doped with dodecylbenzene sulfonic acid, and the matrix polymer WPUA was the used of hydroxyethyl methacrylate (HEMA) to combine polyacrylate with waterborne polyurethane (WPU) by chemical bonds. The waterborne polyurethane‐acrylate‐polyaniline (WPUA‐PANI) films were investigated using dynamic light scattering , contact angle measurements , dynamic mechanical analysis, Fourier‐transform infrared spectroscopy (FTIR), digital highresistance meter and other characterization methods. It was concluded that the base latex has good stability, and when the PANI dispersion content was 35%, the comprehensive performance of the WPUA‐PANI films were the best, in which the maximum water contact angle was 106.8°, the tensile strength was increased from 0.7 MPa to 2.3 MPa, the effective damping temperature range (Tanδ ≥ 0.3) was increased from 50 °C to 87 °C, and the resistivity was reduced from 6.41E + 7 Ω·cm to 1.38E + 4 Ω·cm, which had better antistatic properties. This study will promote the development and application of damping coatings.
Evaluation of robotic fiber placement effect onprocess‐inducedresidual stresses using incrementalhole‐drillingmethod
Authors: Ammar Mohamed M. A. , Shirinzadeh Bijan 
Published: May 2022

AbstractThe robotic fiber placement (RFP) process depends on continuous fusion bonding and solidifying of prepreg tows onto a substrate by subjecting them to a compression force and heat flux. However the advantages provided when using the RFP to fabricate the composite structures, it has adverse effects due to the induced residual stresses (RSs). The current work presents the effect of the RFP on the induced RSs in thermoset composites. RFP is utilized to fabricate specimens from carbon fiber reinforced polymers. Effects of placement speed, compression force, heating temperature, heating gas flowrate, and the location of the heat flux outlet nozzle are all included in the present study. A total of 69 flat panels are manufactured under different process conditions. Subsequently, the in‐depth RSs are measured using the incremental hole‐drilling method. Besides, the microstructures of the samples are also analyzed. The results show that the change in process parameters could significantly affect the induced RSs of the thermoset composites. Subjecting the samples to higher thermal and pressure loads would induce more RSs, which are attributed to the occurrence of partial curing during the manufacturing process along with the change in laminate geometry and porosity.
Genetics of congenital hypothyroidism: Modern concepts
Authors: Stoupa Athanasia , Kariyawasam Dulanjalee , Polak Michel , Carré Aurore 
Published: May 2022

ABSTRACTCongenital hypothyroidism (CH) is the most common neonatal endocrine disorder and one of the most common preventable causes of intellectual disability in the world. CH may be due to developmental or functional thyroid defects (primary or peripheral CH) or be hypothalamic‐pituitary in origin (central CH). In most cases, primary CH is caused by a developmental malformation of the gland (thyroid dysgenesis, TD) or by a defect in thyroid hormones synthesis (dyshormonogenesis, DH). TD represents about 65% of CH and a genetic cause is currently identified in fewer than 5% of patients. The remaining 35% are cases of DH and are explained with certainty at the molecular level in more than 50% of cases. The etiology of CH is mostly unknown and may include contributions from individual and environmental factors. In recent years, the detailed phenotypic description of patients, high‐throughput sequencing technologies, and the use of animal models have made it possible to discover new genes involved in the development or function of the thyroid gland. This paper reviews all the genetic causes of CH. The modes by which CH is transmitted will also be discussed, including a new oligogenic model. CH is no longer simply a dominant disease for cases of CH due to TD and recessive for cases of CH due to DH, but a far more complex disorder.
Investigation of dominant degradation mode in field‐aged photovoltaic modules using novel differential current‐voltage analysis approach
Authors: Meena Roopmati , Kumar Manish , Gupta Rajesh 
Published: May 2022

AbstractPhotovoltaic (PV) modules are susceptible to various types of defects and degradations (D&Ds) under field‐operating conditions, which affect their performance and reliability. These D&Ds have non‐uniform distribution in the PV modules, which makes it difficult to distinguish amongst multiple D&Ds using a single characterization technique. In the present work, a simple non‐destructive characterization approach called differential current‐voltage (DIV) analysis using current‐voltage (I‐V) measurements have been developed for investigation of the dominant degradation mode in the cells of modules, wherein consecutive cells have been partially shaded while measuring the I‐V curve of the modules. For this purpose, a batch of crystalline silicon PV modules operating under hot and humid climatic conditions for 20 years has been investigated. A correlation has been established between the trend of percentage change in modules' electrical parameters during DIV measurements and the dominant degradation mode present in the cell under investigation. The trend of change in short circuit current and voltage at maximum power point has been identified as key electrical parameters to identify the dominant degradation mode in the cell. To analyse the trends of DIV analysis, the effect of prominent degradation modes on the module parameters has been investigated using electrical simulations. The investigated PV modules have been cross‐characterized through microscopic inspection and electroluminescence imaging to identify various D&Ds present in the investigated modules. The results of cross‐characterization substantiate the findings of DIV analysis. The presented DIV approach can be used for the analysis of non‐uniform degradation in the PV plants under field‐operating conditions.
Identifying and predicting teachers' use of practices that support SRL
Authors: Callan Gregory , Longhurst David , Shim Serena , Ariotti Anthony 
Published: May 2022

AbstractThis study examined how teachers support self‐regulated learning (SRL) by examining reports of 15 potential practices and differentiated the use of these practices via teachers' SRL knowledge, beliefs, demographics, and student characteristics. Teachers (n = 112) responded to open‐ended questions targeting SRL knowledge, beliefs, and practices and a demographics survey about themselves and their students. Teachers reported few practices to support SRL, but teachers who used more practices tended to have greater SRL knowledge, teaching experience, and time limits. Reporting excessive responsibility for students negatively correlated with SRL practices. SRL knowledge and limited time were significant predictors in regression analyses. Teachers reported few SRL practices (even when examining 15 potential practices). However, our findings highlight SRL knowledge as a potential first step for teacher trainers and professional developers to target in attempts to increase SRL supports in the classroom.
Social‐emotional learning and physical activity in schools: Practitioner perspectives and initial measurement development
Authors: Greenspan Scott B. , Whitcomb Sara A. , Santana Zachary A. , Fefer Sarah , Hayden Laura 
Published: May 2022

AbstractSchool mental health (SMH) practitioners and physical education (PE) teachers have been identified as key stakeholders in supporting the integration of social‐emotional learning (SEL) and physical activity within schools. Authors of this study developed and administered a survey measure to delineate SMH practitioners' (i.e., school psychologists, school counselors; n = 219) and PE teachers' (n = 138) perspectives of social‐emotional learning (SEL) and PA, and aligning these practices within their work. There were two forms of the measure developed, with one for each stakeholder group. The analytic procedure involved Exploratory Factor Analysis (EFA), descriptive statistics, and analysis of mean differences using independent sample T tests at the factor level. The SMH form brought forth three factors (linking practices, need for training, and current practices), and the PE form brought forth two factors (linking practices and need for training). Survey results suggest that both SMH practitioners and PE teachers agree that there is inherent value in youths' engagement in both SEL and PA and would like increased training to incorporate such practices within their unique roles. SMH professionals rate on average that they “neither agree nor disagree” that they integrate PA within their work. Implications are discussed for both research and practice.
Sorghum root epigenetic landscape during limiting phosphorus conditions
Authors: Gladman Nicholas , Hufnagel Barbara , Regulski Michael , Liu Zhigang , Wang Xiaofei , Chougule Kapeel , Kochian Leon , Magalhães Jurandir , Ware Doreen 
Published: May 2022

AbstractEfficient acquisition and use of available phosphorus from the soil is crucial for plant growth, development, and yield. With an ever‐increasing acreage of croplands with suboptimal available soil phosphorus, genetic improvement of sorghum germplasm for enhanced phosphorus acquisition from soil is crucial to increasing agricultural output and reducing inputs, while confronted with a growing world population and uncertain climate. Sorghum bicolor is a globally important commodity for food, fodder, and forage. Known for robust tolerance to heat, drought, and other abiotic stresses, its capacity for optimal phosphorus use efficiency (PUE) is still being investigated for optimized root system architectures (RSA). Whilst a few RSA‐influencing genes have been identified in sorghum and other grasses, the epigenetic impact on expression and tissue‐specific activation of candidate PUE genes remains elusive. Here, we present transcriptomic, epigenetic, and regulatory network profiling of RSA modulation in the BTx623 sorghum background in response to limiting phosphorus (LP) conditions. We show that during LP, sorghum RSA is remodeled to increase root length and surface area, likely enhancing its ability to acquire P. Global DNA 5‐methylcytosine and H3K4 and H3K27 trimethylation levels decrease in response to LP, while H3K4me3 peaks and DNA hypomethylated regions contain recognition motifs of numerous developmental and nutrient responsive transcription factors that display disparate expression patterns between different root tissues (primary root apex, elongation zone, and lateral root apex).
Protein‐protein interaction networks as miners of biological discovery
Authors: Wang Steven , Wu Runxin , Lu Jiaqi , Jiang Yijia , Huang Tao , Cai Yu‐Dong 
Published: May 2022

AbstractProtein‐protein interactions (PPIs) form the basis of a myriad of biological pathways and mechanism, such as the formation of protein complexes or the components of signaling cascades. Here, we reviewed experimental methods for identifying PPI pairs, including yeast two‐hybrid (Y2H), mass spectrometry (MS), co‐localization, and co‐immunoprecipitation. Furthermore, a range of computational methods leveraging biochemical properties, evolution history, protein structures and more have enabled identification of additional PPIs. Given the wealth of known PPIs, we reviewed important network methods to construct and analyze networks of PPIs. These methods aid biological discovery through identifying hub genes and dynamic changes in the network, and have been thoroughly applied in various fields of biological research. Lastly, we discussed the challenges and future direction of research utilizing the power of PPI networks.