bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil
Authors: Casari Rebecca , Metastasio Antonio , Zamboni Lorenzo , Biasioli Martino , Campagnari Simone , Lugoboni Fabio 
Published: March 2022

IntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous infusion of FLU, a selective BZD receptor antagonist acting on the BZD subunit of the GABA-A receptor. Flumazenil is licensed in the United Kingdom and other countries to treat only BZD overdose although numerous studies have demonstrated its effectiveness in rapidly resetting GABA-A receptors, quickly reducing tolerance and dependence from BZD, and providing a safe and rapid detox from benzodiazepines.ObjectiveThe aim of this article is to provide all healthcare professional who are interested in BZD detoxification with an approach and clear practical information on how to administer FLU.MethodIn this article we outline the approach in detail, describing all medical and nursing procedures day by day. This detox treatment is indicated for patients abusing from at least 5 Defined Daily Dose (DDD) of BZDs or Z-drugs. The process lasts 7 days, and is conducted under medical supervision (daily reviews) and continuous nursing (24/7). During this period, 7mg of FLU is administered (1 mg/24) through an elastomeric pump, via continuous subcutaneous infusion.ConclusionTo this day, the largest database of FLU detoxification was published by our group, showing how this treatment is safe, with very little side effects even in patients with significant medical comorbidities.
A Review of the Components of Problematic Exercise in Psychometric Assessment Instruments
Authors: Sicilia Álvaro , Alcaraz-Ibáñez Manuel , Paterna Adrian , Griffiths Mark D. 
Published: March 2022

BackgroundsThe range of theoretical conceptualizations of problematic exercise in psychometric assessment instruments makes it difficult to identify the components that define this phenomenon. A better understanding of the underlying components of problematic exercise may contribute to progress toward providing scientific evidence that allows for deciding whether problematic exercise should be considered a substantive mental health disorder. The objective of the present review was to examine and compare, through a content analysis of their items, the components of problematic exercise in psychometric assessment instruments identified in a recent systematic review.MethodsA total of 33 components of problematic exercise were identified in the 17 assessment instruments included in the present review.ResultsThe results show that, despite the lack of consensus in the operational definition of their factors and the variety of ways of wording their items, the instruments reflect some common components that might indicate core criteria (i.e., salience, withdrawal, and mood modification) or candidate components (i.e., conflict, and continuance despite problems) of problematic exercise. However, other components of different nature were shown to be specific to some of the problematic exercise conceptualizations on which the assessment instruments are based.ConclusionIn the interest of reaching a consensus that allows to advance in this research field, further studies are needed to resolve which components are inherently problematic.
Higher Pathological Complete Response Rate of Less than 10 Total Axillary Lymph Nodes After Axillary Lymph Node Dissection Following Neoadjuvant Chemotherapy in Breast Cancer
Authors: Lee Jeeyeon , Park Nora Jee-Young , Kang Byeongju , Jung Jin Hyang , Kim Wan Wook , Chae Yee Soo , Lee Soo Jung , Kim Hye Jung , Park Ji-Young , Park Ho Yong 
Published: March 2022

BackgroundThe American Joint Committee on Cancer (AJCC) guideline recommends the evaluation of ≥10 axillary lymph nodes (ALN) in patients with breast cancer to assess the N stage. However, the total ALN count in ALN dissection (ALND) often decreases after neoadjuvant chemotherapy in breast cancer. The authors compared clinicopathological factors and oncological outcomes between &lt;10 vs. ≥10 ALNs after ALND following neoadjuvant chemotherapy in breast cancer.MethodsData of 159 patients with breast cancer, treated with neoadjuvant chemotherapy and ALND, were reviewed, and the cases were classified into two groups (&lt;10 vs. ≥10 ALN count). The treatment response was determined based on the RECIST 1.1 criteria, and histopathological regression of the tumor was assessed based on the Miller-Payne grading scales.ResultsMost of the clinical and pathological factors did not demonstrate any significant differences between the two groups. However, the pathological complete response (pCR) rate in breast lesion and ALNs were the higher trend in the group with &lt;10 ALNs. During the 88-month follow-up period, there was no significant difference in locoregional recurrence, distant metastasis, or overall survival.ConclusionsAlthough there was a limitation due to different sample sizes, additional axillary surgery may not be necessary even in cases with &lt;10 total ALNs after ALND, following neoadjuvant chemotherapy because the lymph nodes are more likely to have been regressed themselves due to neoadjuvant chemotherapy, and the residual lymph nodes may be absent.
Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival
Authors: Lim Zi Lin , Lim Geok Hoon , Ho Peh Joo , Khng Alexis Jiaying , Yeoh Yen Shing , Ong Amanda Tse Woon , Tan Benita Kiat Tee , Tan Ern Yu , Tan Su-Ming , Tan Veronique Kiak-Mien , Li Jingmei , Hartman Mikael 
Published: March 2022

Physical activity (PA) is known to reduce breast cancer (BC) risk and improve patient prognosis. However, the association between pre-diagnostic PA and the aggressiveness of BC is unclear. We investigated the associations between PA, BC tumour characteristics, and survival. This retrospective observational study included 7688 BC patients from the Singapore Breast Cancer Cohort (2010–2016). PA information from the questionnaire included intensity (light/moderate/vigorous) and duration (<1 h/1–2 h/>2 h per week). A PA score (1–5) incorporating intensity and duration was calculated. Associations between PA score and tumour characteristics such as stage, histological grade, nodal and hormone receptor status were examined using multinomial regression. Moreover, 10-year overall survival was estimated using Cox regression analysis in 6572 patients after excluding patients with invalid survival data and stage IV disease. Breast tumours associated with higher PA score were more likely to be non-invasive (ORinvasive vs. non-invasive(reference) [95% CI]: 0.71 [0.58–0.87], p-trend = 0.001), of lower grade (ORpoorly vs. well differentiated(reference): 0.69 [0.52–0.93], p = 0.014), ER-positive (ORER-negative vs. ER-positive(reference): 0.94 [0.89–1.00], p-trend = 0.049), PR-positive (ORPR-negative vs. PR-positive(reference): 0.82 [0.67–0.99], p = 0.041), HER2-negative (ORHER2-negative vs. HER2-positive(reference): 1.29 [1.02–1.62], p-trend = 0.002), and less likely to be of HER2-overexpressed subtype (ORHER2-overexpressed vs. Luminal A(reference): 0.89 [0.81–0.98], p-trend = 0.018). These associations (odds ratios) were more pronounced among post-menopausal patients. A higher PA score did not improve survival. Higher levels of pre-diagnostic PA were associated with less aggressive tumours in BC patients. This illustrated another benefit of PA in addition to its known role in BC risk reduction.
La métrica del vivir bien: Construcción de un índice de reconciliación y equilibrio
Authors: Quiroga Canaviri Jorge León , Zaiduni Salazar Marcelo Eduardo 
Published: March 2022

En respuesta a cuán y cómo de bien se vive, la presente investigación tuvo como objetivo generar un índice de desarrollo considerando los fundamentos filosóficos, culturales, costumbristas y lingüísticos del paradigma prevalente del Vivir Bien. El andamiaje estadístico - matemático desarrollado se ajustó al modelo boliviano basado en los 25 principios propuestos por Choquehuanca. Partiendo de los fundamentos de la tetraléctica y la tetrasociología, se formaron pautas para desarrollar un propio modelo ontológico que ayude a definir las dimensiones y las variables que mejor describan este paradigma. Como resultado se propuso un índice conceptualmente robusto – Índice del Vivir Bien (IVB) – que supera los índices de pobreza, desarrollo humano y otras métricas, configurado en un sistema en el que la Bioeconomía juega un rol preponderante para llegar a la pentaléctica. Se resalta la importancia de habilitar una conexión con la economía, lo social y medioambiental, que permita consolidar una base ética, moral e ideológica que promueva el Vivir Bien como fundamento transversal, tanto interna como internacionalmente.
Customer-Based Brand Equity in Indonesia's Higher Education Institution
Authors: Tammubua Milcha Handayani 
Published: March 2022

Objective: This study aimed to examine the causal order among dimensions of customer-based brand equity (CBBE) in Indonesian higher education institutions. The core dimensions of brand equity used are brand awareness, brand association, perceived quality, and brand loyalty. Research Design & Methods: This study used a research instrument questionnaire with a 5-point Likert scale. The research sample is 150 students of the Universitas Terbuka in Jayapura. The research hypotheses were tested using PLS-SEM with the SmartPLS version 3 as the supporting software. Findings: The results showed a causal order among the CBBE dimensions. Brand awareness has a positive and significant effect on perceived quality. The perceived quality has a positive and significant effect on brand loyalty, and brand awareness indirectly affects brand loyalty through perceived quality. This study cannot prove the moderating role of brand association on the relationship between brand awareness and perceived quality. Implications & Recommendations: This study provides implications and recommendations for the management of higher education institutions to create brand loyalty with a gradual process starting from developing a brand awareness strategy and then building positive perceived quality. Contribution & value Added: This study significantly extends the CBBE literature in the higher education institution sector, especially in Indonesia, which is still rarely studied. This study provides novelty by examining causal sequences and interactions on the CBBE dimensions.
Role of Prophylactic Use of Amiodarone to Prevent Post-Operative Dysrhythmias in Patients with Low Ejection Fraction (EF ≤35%)
Authors: Ali Rai Shumaila , Ali Chaudhry Amjad , Qureshi Muhammad Arsalan 
Published: March 2022

ABSTRACT:
Objective:
To determine the role of amiodarone prophylaxis in the prevention of dysrhythmias following coronary artery bypass grafting (CABG) in patients with low ejection fraction (EF).
Methods:
In this prospective comparative study, we included150 patients who underwent coronary artery bypass grafting (CABG) in Multan Institute of Cardiology within a duration of 07 months from Jan-2019 to Aug-2019 having low ejection fraction (EF ≤35%). In the intervention(amiodarone) group (N=75), 3 mg/Kg of amiodarone was given after removal of X-clamp and before weaning from cardiopulmonary bypass. while in the remaining 75 patients no anti-arrhythmic treatment was given in the peri-operative period. Occurrence of postoperative arrhythmia (AF and bradycardia) during the primary hospital stay after surgery was a primary study endpoint.
Results:
There was no significant difference between the mean age, gender and body mass index (BMI) of patients in the two groups. Regarding per-operative data, there was no significant difference in number of grafts in amiodarone group 3.9±0.53 and control group 3.04±0.50 (p-value 0.20). Frequency of Atrial fibrillation (AF) after the surgery was significantly differenced in both groups. In the amiodarone group, 13 (17.3%) patients developed POAF and in the control group, POAF occurred in 25 (33.3%) patients (p-value 0.024).
Conclusion:
Amiodarone prophylaxis significantly lower the incidence of POAF after CABG in patients with low EF. Amiodarone is easy to administer and is a valuable adjuvant for prevention of POAF.
Experiences of Web Searches for Medical Information Purposes on Health Anxiety in the general population reporting to tertiary care hospitals of Rawalpindi
Authors: Mohi Ud Din  , Syed Fawad Mashhadi  , Shahrob Khan  , Tehreem Safdar  , Bilal Ashraf  , Zeeshan Khalid Awan  
Published: March 2022

Objective: To assess the prevalence of internet use for medical purposes by the general public and to correlate it with anxiety levels.
Materials and methods: An analytical cross-sectional study was conducted in tertiary care hospitals of Rawalpindi from August to December 2020. Ethical approval was taken. A sample size of 385 was calculated through Rao software. Non-probability convenient sampling technique was used. Informed consent was taken. A validated questionnaire was used. The data was analysed using IBM SPSS Statistics Version 25. Frequencies and percentages were calculated. Chi-square test of significance was applied. P-value less than .05 was considered as statistically significant.
Results: A majority of the participants used the internet to obtain health-related information. Majority of the subjects stated that the health-related searches exacerbated their anxiety. The negative effects of excessive or inappropriate internet use are stronger in women than in men. Participants from lower income groups were more prone to anxiety, however participants from higher income groups were slightly more likely to visit a doctor for a perceived health condition. The internet was helpful in understanding the terminology used by doctors for majority of the participants.
Conclusion: The study found that most people who use the internet also use it for health related searches. There is a positive correlation between excessive health-related internet use and health anxiety. This correlation is stronger in women. Looking up medical terminology on the internet makes it easier for patients to communicate with doctors and understand their condition.
Keywords: Anxiety, web searches, internet, cyberchondria
News of Zubarah Family- Unionists in Nishapur and their Scientific Contributions in the two Centuries (4-6 AH/10-12 AD)
Authors: Al Anbaki Shaymaa Fadhel Abdel Hamid 
Published: March 2022

This research is concerned with qualitatively studying the history of an ancient family, one of the most prominent noble, Alawite families, that assumed the position of the Student Union for the Alawite Supervision in the city of Nishapur in Khorasan during the centries (4-6 H./ 10-12 A.H.). Thus, the research aims to investgate the historical news, and the outstanding Zubarah figures who experience the supereme the religious, historical and scientific position in Khorasan generally and Nishapur particularily. It further aims at arriving at the true meaning of the name Zubarah, and to whom it was called, and the extent of this family’s affiliation to the noble Alawi House, and how they moved to live and settle in the cities of the East, including Tabaristan and Abe, then Nishapur, and the establishment of the Alawi and student union to manage the affairs of the honorable gentlemen, take care of them to preserve lineage from confusion, and to look into religious, social and scientific affairs. Thus, the importance of the research lies in knowing everything related to the Zubarah family and what they presented during their presence in the position of the student union in the East in the service of the Prophet and the upper house. The research is like reviving a mention of the glories of this family with a pioneering role in Khorasan, especially the cities of Nishapur and Bayhaq. The research ends with a set of conclusions, such as: the name of Zubarah family goes back to its elder grandfather, Mohammad Al-Akbar, nicknamed Zubarah. This is because when he got angery on right things, his voice got higher and his face got redder, like a lion when he roars. Their affinity goes back to Al-Husseini Alawi House. Zubarah family had many followers in Nishapur and Bayhaq, who had a religious and social role and distinguished scientific contributions in various sciences and knowledge.
Social Risks and Development Gaps in Iraq: A Social Study in the City of Baghdad Mais Mohammed Kadhum
Authors: Kadhum Mais Mohammed 
Published: March 2022

Social risks posed a great challenge to the development path in Iraq, which resulted in widening the development gaps, whether these gaps were between rural and embargoed areas, or between Iraqi governorates, and the gender gap. Besides, the nature of the reciprocal relationship between the social risks and the development process requires the adoption of development trends that are sensitive to the risks that take upon themselves the prompt and correct response to these risks, away from randomness and confusion that Iraq suffered from for decades. However, currently, the situation has differed a great deal. This is because the size and types of such gaps have widened and become more complicated than before; a matter which has led to have clear development gaps due to the differences and distances ensued among the Iraqi governments, the areas of rural and urban, in addition to the gender gap. The research has adopted the social sampling method by building a scale consisting of (21) paragraphs and four-way answer alternatives (agree completely, agree, do not agree, do not agree at all). The scale has been applied to a sample of (100) sociology specialist respondents. The research reached several conclusions, the most important of which are: The nature of the rapid and continuous social changes imposed new forms of social risks that are not familiar before and which are difficult to deal with. The problem of persistent inequality at the level of societies and individuals is one of the most serious challenges that can generate new opportunities for more deadly social risks.
نفي وإبعاد الأحداث: دراسة فقهية مقارنة بقانون الأحداث الجانحين والمشردين الإماراتي
Authors: عثمان سعدية , النور محمد 
Published: March 2022

النفي من العقوبات المقررة في الشريعة الإسلامية باعتبارها دواءً لبعض الجرائم، ومن ذلك جرائم الحرابة، فأصل النفي لا خلاف فيه، بعبارة أخرى النفي عقوبة غير مستحدثة وجدت في محاربة بعض الجرائم، ولكن الإشكال وقع عندما نُظِرَ إلى سِنّ الجاني، فالجناة متفاوتون في الأعمار، فمنهم الصغير ومنهم الكبير، والنفي في حق الصغير أو ما يسميه القانون اليوم بالحدث، هذه المسألة بحاجة إلى بيان المشروعية؛ لذلك جاء هذا البحث موسوماً بــ: (نفي وإبعاد الأحداث: دراسة فقهية مقارنة بقانون الأحداث الجانحين والمشردين الإماراتي).
اشتمل البحث على مبحثين، الأول: عالج حكم نفي الحدث في الفقه وقانون الأحداث الجانحين والمشردين، والآخَر: عالج مسألة شروط إبعاد الحدث في الفقه وقانون الأحداث الجانحين والمشردين. وقد اعتمد البحث على المنهج الاستقرائي والتحليلي والمقارن.
وتوصلت الدراسة إلى مجموعة من النتائج، ومنها:

لا يجوز شرعاً نفي الحدث غير المميِّز، وكذلك المميِّز قبل مرحلة البلوغ، فالنفي يشترط له العقل؛ فلا ينفى الصغير غير المميِّز، ويشترط له البلوغ؛ فلا ينفى الصبي المميز.
لا ينفى في التشريع الإماراتي الحدث الذي لم يتم ١٦ سنة من عمره، ولكن يستثنى البالغ العاقل الذي لم يتم ١٦ سنة استناداً إلى قانون العقوبات دون قانون الأحداث.
الوسواس القهري وأثره في أفعال المكلف (الطهارة والصلاة)
Authors: القحطاني هند 
Published: March 2022

لم يهمل العلماء قديما الحديث حول الوساوس التي تعتري المسلم في عباداته. ومع تقدم العلم والطب تحديداً ظهر نوع من الوساوس وهو الوسواس القهري، وعرّفه الأطباء النفسيون كمرض نفسي يحتاج معه المريض للعلاج بحسب حالته، ولما لهذا المرض من أثر في طهارة المكلف وصلاته رأيت البحث حوله، وتوضيح الفرق بين الوسواس القهري كمرض نفسي وغيره من الوساوس الأخرى.
وقد توصلت من خلال البحث لعدد من النتائج، وهي:

يختلف الوسواس القهري عن غيره من الوساوس، فهو نوع من أنواعها بشكل عام.
الوسواس القهري مرض نفسي كغيره من الأمراض التي تصيب الإنسان، ويحتاج معه إلى تدخل الطب النفسي في علاجه.
عرّف الأطباء النفسيون الوسواس القهري بأنه: مرض عصابي يتميز بوجود أفكار أو اندفاعات أو مخاوف حركية مستمرة أو دورية.
من الأمور النافعة لعلاج الوسواس القهري ذكر الله تعالى والدعاء والاستغفار والاستعاذة واستحضار القلب عند العبادة. إضافة للعلاج النفسي المعرفي السلوكي أو العقاقير الطبية.
ليس على مريض الوسواس القهري إعادة إن شك في وضوئه، وذلك قطعا للوسوسة عنه.
مريض الوسواس القهري إذا غلب على صلاته الوسواس فلا يجب عليه إعادتها كما هو المختار في المسألة.
النية محلها القلب دون اللسان. ولا يُندب النطق بالنية إلا لمن يعتريه الوسواس.
CORRELATION BETWEEN VITAMIN D LEVELS AND PEDIATRIC ANTHROPOMETRY STATUS IN NEONATES
Authors: Sari Tri Elina , Muslimin Muslimin , Radityo Adhie Nur , Pratiwi Rina 
Published: March 2022

Background: Problems of vitamin D deficiency is now starting to become a concern in the world because 1 million people worldwide have vitamin D deficiency and nearly 50% have vitamin D insufficiency. Vitamin D deficiency is more common in neonates which can
increase the risk of low birth weight and also effect on baby length, head circumference. Aim: Understanding the correlation between vitamin D levels and anthropometric status in neonates.Method: This study used an observational analytic study with a cross sectional approach. The research sample was neonates at term. The data from questionnaires and direct anthropometric measurements on neonates who came to delivery room and pediatric polyclinic of the Diponegoro National Hospital, Semarang and Dr. Kariadi General Hospital, Semarang. The data normality test used the Saphiro-Wilk test. Correlation test between vitamin D levels and anthropometric status using the Pearson test, and test levels of vitamin D with nutritional status (WHZ, WAZ, HAZ) using the Spearman test.Results: Median (min-max) neonatal vitamin D levels were 12.12 (6.09 - 19.52). There was no significant correlation between vitamin D levels and neonatal age, neonatal anthropometric status, maternal sun exposure and neonatal diet type. This is influenced by several other factors that are consistent with the theory such as neonatal nutrition, genetics, time and length of sun exposure, poor dietary intake.Conclusion: There was no significant correlation between vitamin D levels and weight, body length, height, nutritional status of WHZ, WAZ, HAZ in neonates.