bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel SRR inspired CPW-Fed Dual Band MIMO Antenna for Sub-6 GHz 5G Application
Authors: Mood Yugender , R Pandeeswari 
Published: September 2022

Abstract
The metamaterial inspired novel CPW fed MIMO antenna design works based on the principle of Non Bianisotropic- Split-Ring Resonator and amalgamation of Hexagonal Open Ring Resonator(HexORR) thereby resulting in a miniaturized antenna with dimensions of 47.4 × 31.7 × 1.6 mm3 .This antenna holds decent for the Sub6 GHz 5G application covering bandwidth of 983.5 MHz (3.7887 - 2.8052 GHz) and 551.6 MHz (6.3834 - 5.3818 GHz) with center frequency of 3 GHz and 6 GHz, respectively. The lower frequency band is produced using hex-ORR, and a higher frequency band is provided using NB-SRR. The size of the antenna is optimized by considering the Non Bianisotropic-SRR size minor than the resonant wavelength. The proposed MIMO antenna parameters such as ECC, CCL, and TARC are also examined, and the results indicate that the proposed antenna design is a good candidate for sub-6GHz 5G applications.
Catchment Morphometric Characterization of the Akaki River in the Upper Awash Sub-Basin, Ethiopia
Authors: Sisay Mamo Kassegn 
Published: September 2022

Abstract
Morphometry is the measurement and analysis of a catchment in the form of fingerprint characteristics. Morphometric studies play an important role in the areas of soil and water conservation, flood control, pollutant and waste management and socio – environmental protection. In this study, morphometrical data analysis indices are gained from high-resolution (12.5 m X 12.5 m) digital elevation model dataset for the of the Akaki watershed. The techniques performed using spreadsheet, R-programming, and ArcGIS tools. Results designate the Akaki watershed as dendritic drainage with elongated channels and irregular spreading streams ramifications. The big Akaki is the longest distance routing river among tributaries in the watershed. The Akaki watershed is expressed by 25% of steep sloppy coverages of Entoto, Yeka, and Sebeta mountainous areas. The implication on the morphometry of the catchment is to higher lag time of flow to reach its outlet. But the flood risk in the downstream areas can be due to the urban and peri – urban land uses with high pavement structures. In terms of the topographic wetness index (TWI), the higher elevation and river abatements areas have low moisture-holding capacities due to the hypsometrical characteristics of the landforms. High rainfall with lower evaporation rate recordings implies that the watershed has good groundwater recharge with good aquifer characteristics. This study could be a primary source of information for future development projects of watershed management, urban planning, riverside rehabilitation, flood controls and stormwater management practices in the Akaki watershed.
IL-33 induces histidine decarboxylase in mouse tissues, especially in c-kit+ cells and mast cells, and negatively regulates eosinophilia
Authors: Bando Kanan , Tanaka Yukinori , Winias Saka , Sugawara Shunji , Mizoguchi Itaru , Endo Yasuo 
Published: September 2022

Abstract
Objective and Methods
IL-33 is present in endothelial, epithelial, and fibroblast-like cells and released upon cell injury. IL-33 reportedly induces mast-cell degranulation and is involved in various diseases, including allergic diseases. So, IL-33-related diseases seem to overlap with histamine-related diseases. In addition to the release from mast cells, histamine is newly formed by the induction of histidine decarboxylase (HDC). Some inflammatory and/or hematopoietic cytokines (IL-1, IL-3, etc.) are known to induce HDC, and the histamine produced by HDC induction is released without storage. We examined the involvement of HDC and histamine in the effects of IL-33.
Results
A single intraperitoneal injection of IL-33 into mice induced HDC directly and/or via other cytokines (including IL-5) within a few hours in various tissues, particularly strongly in hematopoietic organs. The major cells exhibiting HDC-induction were mast cells and c-kit+ cells in bone marrow. HDC was also induced in non-mast cells in non-hematopoietic organs. HDC, histamine, and histamine H4 receptors (H4Rs) contributed to suppression of IL-33-induced eosinophilia.
Conclusion
IL-33 directly and indirectly (via IL-5) induces HDC in various cells, particularly potently in c-kit+ cells and mature mast cells, and the newly formed histamine contributes to negative regulation of IL-33-induced eosinophilia via H4Rs.
Relativistic Hydrodynamic Interpretation of de Broglie Matter Waves
Authors: Dagan Yuval 
Published: September 2022

Abstract
We present a classical hydrodynamic analog of free relativistic quantum particles inspired by de Broglie's pilot wave theory and recent developments in hydrodynamic quantum analogs. The proposed model couples a periodically forced Klein-Gordon equation with a nonrelativistic particle dynamic equation. The coupled equations may represent both quantum particles and classical particles driven by the gradients of locally excited Faraday waves. Exact stationary solutions of the coupled system reveal a highly nonlinear mechanism responsible for the self-propulsion of free particles, leading to the onset of unsteady motion. Although the model is essentially nonrelativistic, a stabilizing mechanism for any particle traveling close to the wave signaling speed emerges through the coupling with the wavefield. Consequently, inline particle oscillations comparable to de Broglie's wavelength formula are realized through this fully-classical model, suggesting a new classical interpretation for the motion of relativistic quantum particles.
Optimization of conditions for in vitro modelling of subgingival normobiosis and dysbiosis
Authors: Baraniya Divya , Do Thuy , Chen Tsute , Albandar Jasim , Chialastri Susan , Devine Deirdre A. , Marsh Philip D. , Al-hebshi Nezar 
Published: September 2022

Abstract
Modeling subgingival microbiome in health and disease is key to identifying the drivers of dysbiosis and to studying microbiome modulation. Here, we optimize growth conditions of our previously described in vitro subgingival microbiome model. Subgingival plaque samples from healthy and periodontitis subjects were used as inocula to grow normobiotic and dysbiotic microbiomes in MBEC assay plates. Saliva supplemented with 1%, 2%, 3.5% or 5% (v/v) heat-inactivated human serum was used as a growth medium under shaking or non-shaking conditions. The microbiomes were harvested at 4, 7, 10 or 13 days of growth (384 microbiomes in total) and analyzed by 16S rRNA gene sequencing. Biomass significantly increased as a function of serum concentration and incubation period. Independent of growth conditions, the health- and periodontitis-derived microbiomes clustered separately with their respective inocula. Species richness/diversity slightly increased with time but was adversely affected by higher serum concentrations especially in the periodontitis-derived microbiomes. Microbial dysbiosis increased with time and serum concentration. Porphyromonas and Alloprevotella were substantially enriched in higher serum concentrations at the expense of Streptococcus, Fusobacterium and Prevotella. An increase in Porphyromonas, Bacteroides and Mogibacterium accompanied by a decrease in Prevotella, Catonella and Gemella were the most prominent changes over time. Shaking had only minor effects. Overall, the health-derived microbiomes grown for 4 days in 1% serum, and periodontitis-derived microbiomes grown for 7 days in 3.5%-5% serum were the most similar to the respective inocula. In conclusion, normobiotic and dysbiostic subgingival microbiomes can be grown reproducibly in saliva supplemented with serum, but time and serum concentration need to be adjusted differently for the health and periodontitis-derived microbiomes to maximize similarity to in vivo inocula. The optimized model could be used to identify drivers of dysbiosis, and to evaluate interventions such as microbiome modulators.
Brain Transport of Docosahexaenoic Acid Across the Blood–Brain Barrier Decreases in Middle-Aged and Aged Mice
Authors: Iwao Takuro , Takata Fuyuko , Matsumoto Junichi , Aridome Hisataka , Yasunaga Miho , Yokoya Miki , Kataoka Yasufumi , Dohgu Shinya 
Published: September 2022

Abstract
Background: Nutrients are actively taken up by the brain via various transporters at the blood–brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To compensate for decreased brain DHA, orally supplied DHA must be transported from the circulating blood to the brain across the BBB through transport carriers including major facilitator superfamily domain-containing protein 2a (MFSD2A) and fatty acid-binding protein 5 (FABP5) that transport esterified and non-esterified DHA, respectively. Although it is known that the integrity of the BBB is altered during aging, the impact of aging on DHA transport across the BBB has not been fully elucidated. Methods: We used 2-, 8-, 12-, and 24-month-old male C57BL/6 mice to evaluate brain uptake of [14C]DHA, as the non-esterified form, using an in situ transcardiac brain perfusion technique. Primary culture of rat brain endothelial cells (RBECs) was used to evaluate the effect of siRNA-mediated MFSD2A knockdown on cellular uptake of [14C]DHA.Results: We found that brain uptake of [14C]DHA was inhibited by excess unlabeled DHA in 2-month-old mice. Transfection of MFSD2A siRNA into RBECs decreased the MFSD2A protein expression levels by 30% and reduced cellular uptake of [14C]DHA by 20%. Twelve- and 24-month-old mice exhibited significant reductions in brain uptake of [14C]DHA and decreased MFSD2A protein expression in the brain microvasculature compared with 2-month-old mice; nevertheless FABP5 protein expression was up-regulated with age. Conclusions: We demonstrated that MFSD2A is involved in non-esterified DHA transport at the BBB. The middle-aged and aged brain has decreased DHA transport across the BBB due to age-related down-regulation of MFSD2A rather than that of FABP5.
Investigation of Bedaquiline Resistance and Genetic Mutations in Multi-Drug Resistant Mycobacterium tuberculosis Clinical Isolates in Chongqing, China
Authors: Hu Yan , Fan Jun , Zhu Damin , Liu Wenguo , Li Feina , Li Tongxin , Zheng Huiwen 
Published: September 2022

Abstract
Background: To investigate the prevalence and molecular characterization of bedaquiline resistance among MDR-TB isolates collected from Chongqing, China. Methods: A total of 205 MDR-TB isolates were collected from Chongqing Tuberculosis Control Institute between March 2019 and June 2020. The MICs of BDQ were determined by the microplate alamarblue assay. All strains were genotyped by melting curve spoligotyping, and were subjected to whole-genome sequencing. Results: Among the 205 MDR isolates, the resistance rate of BDQ was 4.4% (9/205). The 55 (26.8%) were from male patients and 50 (24.4%) were new cases. Furthermore, 81 (39.5%) of these patients exhibited lung cavitation, 13 (6.3%) patients afflicted with diabetes mellitus, and 170 (82.9%) isolates belonged to Beijing family. However, the distribution of BDQ resistant isolates showed no significant difference among these characteristics. Of the 86 OFX resistant isolates, 8 isolates were XDR (9.3%, 8/86). Six BDQ resistant isolates (66.7%, 6/9) and two BDQ susceptible isolates (1.0%, 2/196) carried mutations in Rv0678. A total of 4 mutations types were identified in BDQ resistant isolates, including mutation in A152G (50%, 3/6), T56C (16.7%, 1/6), GA492 insertion (16.7%, 1/6), and A274 insertion (16.7%, 1/6). BDQ showed excellent activity against MDR-TB in Chongqing. Conclusions: BDQ showed excellent activity against MDR-TB in Chongqing. The resistance rate of BDQ was not related to demographic and clinical characteristics. Mutations in Rv0678 gene were the major mechanism to BDQ resistance, with A152G as the most common mutation type. WGS has a good popularize value and application prospect in the rapid detection of Bdq resistance.
Steady-State Wave Responses of One-Dimensional Multi-Degree-of-Freedom Lattices with Strong Nonlinearities by an Improved Incremental Harmonic Balance Method
Authors: Wang Hongyu , Wang Xuefeng , Zhao Jian , Zhang Jian , Huang Yu 
Published: September 2022

Abstract
The nonlinearity plays an important role in modulation of wave propagation characteristics, such as the adjustment of band structures by media nonlinearities. There was a modified incremental harmonic balance (IHB) method developed to hand single- and two-degree-of-freedom (2-DoF) wave propagation problems with nonlinearities. When the nonlinearity is strong, high-order basis functions are used to achieve accurate solutions, which requires complex formula derivation and high computational effort, especially for a general multi-DoF wave problem. To handle the issue, an improved IHB method is developed for solving multi-DoF wave problems with strong nonlinearities. In the method, construction of analytical Jacobian matrices of delay differential equations that are transformed from original wave problems is formulated for any DoFs and expansion orders, by which no manual derivation and numerical integration are needed. Thus, computational effort can be significantly reduced, and convergence analysis of solutions obtained from the IHB method with different expansion orders can be conducted to determine the minimum order of stable solutions, which has not been done for wave problems with strong nonlinearities. Moreover, the algorithm to solve nonlinear wave problems with given frequencies and unknown wave vectors is newly proposed in this work based on the improved IHB method, which is can be a more efficient approach if external excitations are given. In this work, one-dimensional diatomic lattices with Hertz contact law and cubic spring models are studied as examples, where dispersion curves and bandgap properties are generated. Results show that it is necessary to use high-order Fourier functions to obtain accurate steady-state wave responses when strong nonlinearities exist, which was not explicitly recognized in past works without convergence analysis for wave problems. Results also show that the convergence rate of the method with use of a fixed frequency is faster than that of a fixed wave vector.
Revisiting the amalgaviral landscapes in plant transcriptomes expands the host range of plant amalgaviruses
Authors: Sidharthan V Kavi , Rajeswari V , Vanamala Gayatri , Baranwal V K 
Published: September 2022

Abstract
Plant amalgaviruses are monopartite, double-stranded RNA genome containing viruses, capable of vertical transmission through seeds. An attempt to revisit the plant transcriptome assembled contigs for amalgaviral sequences identified 40 putative novel amalgaviruses in 35 plant species, nearly doubling the number of known plant amalgaviruses. Of the 35 plant species, 33 species are reported to host amalgaviruses for the first time, including a pteridophytic and two gymnospermic species. Coding-complete genomes of all the identified viruses were recovered and the putative + 1 programmed ribosomal frameshift (PRF) sites were determined. The genomes of 35 identified amalgaviruses contained the conserved + 1 PRF motif ‘UUU_CGN’, while variant versions were predicted in five of the genomes. Phylogenetic analysis grouped pteridophyte- and gymnosperm-infecting amalgaviruses together in a divergent clade while few of the related angiosperm-infecting amalgaviruses infect members of the same plant family, reiterating the co-evolution of plant amalgaviruses and their hosts. The current study paves way for further studies on understanding the biological properties and developing detection assays of identified viruses.
Brusatol Suppresses Bladder Cancer by downregulating the expression of Nrf2
Authors: Yu Xi , Li Shenglan , Wang Huaxing , Ye Chenglin , Wang Lei , Liu Xiuheng 
Published: September 2022

Abstract
A substance called brunsatol, which is derived from the dried ripe fruit of Brucea javanica, has been shown to be active against a variety of human cancers, but not against bladder cancer (BCa). In the present study, we attempted to investigate the effect of brusatol in BCa and verify whether Nrf2 was involved in the mechanism. The effect of brusatol was assessed by CCK8 and colony formation assays. Transwell analysis were performed to detect the migration of bladder cancer cell lines under treatment of brusatol. Apoptosis was determined by flow cytometry. Finally, Western blot was used to explore the mechanism of brusatol regulating the BCa progression and Nrf2. We revealed that brusatol inhibited the growth of BCa cells in vitro and in vivo and decreased their invasion ability. Mechanistic analysis revealed that brusatol decreased the expression of Nrf2 which functions as a tumor promoter in the development of BCa. And Nrf2 overexpression reversed the inhibitory effects induced by brusatol. Finally, brusatol inhibited the proliferation and invasion of BCa cells via Akt signaling-mediated Nrf2 expression. These results suggest that brustasol is a valuable potential antitumor drug available for BCa.
Integration of Remote sensing and Google Earth Engine for land use/ land cover change analysis in small agricultural watershed (A case of Brante watershed, Ethiopia)
Authors: Gashu Melaku Wendachew 
Published: September 2022

Abstract
The GEE is a cloud computing platform which provide the infrastructure to access and process large amounts of regularly updated earth observation data rapidly in a systematic using GEE. To classify and map LULC time series (2015-2021) of the Brante watershed supervised classification was performed using Random forest classifier and the image was classified into four classes which are agriculture, forest, grassland and wet land .In the 2015 grassland was the dominant type of Land use classified which covers about 62.5 % of the total study. But in 2021 agriculture was the dominant type of Land use classified which covers about 45.0% of the total study. The accuracy assessment indicate random forest classifier is good to prepare the land use/land cover map of the study area the Brante catchment. Furthermore, it is recommended by combining remote sensed techniques with in situ observations about changes in land use and ground truth observed data, the comprehensiveness of analyses of this study can further be enhanced.
Adoptees’ views and experiences of Direct to Consumer (DTC) genomic testing: an exploratory interview study from the UK
Authors: Kay Alison C. , Taverner Nicki 
Published: September 2022

Abstract
Direct-to-Consumer (DTC) genomic testing for ancestry and health may appeal to adoptees looking to fill gaps in their family information. There are only a handful of published studies on adoptees’ views and experiences of DTC testing and none of these are from the UK. The recent UK House of Commons Science and Technology Committee report (Gov 2021) did not address the gains or challenges for adopted people specifically, although the Committee did consider that robust evidence of opportunities or risks for any user of a DTC testing kit is limited. In this study presented here, semi-structured interviews were conducted with ten UK adult adoptees recruited via social media. Reflexive thematic analysis (Braun and Clarke 2006, 2019) of the interview transcripts identified three main themes: Decisional influencers of longing, uncertainty and normalization of DNA kit use; Informational drivers to gain clarity but avoid new worrisome information; and talk around Negotiating Visibility to birth family and commercial third parties. A further theme of Meaning Making related to adoptees’ views of testing outcomes as bringing feelings of resolution or discordance. This study identified many challenging deliberations for adoptees in evaluating whether to take a DTC test and what to do when their results were returned. Additionally, adoptees’ consideration of data privacy issues appears hampered by already having shared identifying information about themselves in their wider adoptee search. Further research is encouraged.
A Different Approach to Breast Self-Examination Training: Family Training
Authors: Ayran Gulsun , Gundogdu Gulsum , Yaman Ece , Kutluata Sema 
Published: September 2022

Background. Breast self-examination (BSE) is an effective, cost-free, early diagnosis method that enables women to take responsibility for their own health in the early diagnosis of breast cancer, which is the most common cause of death in women.
The objective of the study was to determine the effect of BSE training given by female nursing students to their mothers and sisters on their BSE behavior and self-esteem.
Materials and Methods. This study is of one-group pretest-posttest quasi-experimental design. It was carried out at the Faculty of Health Sciences of Erzincan University in Turkey between December 2019 and May 2020. The universe of the study consisted of 140 third- and fourth-year female students over the age of 18 enrolled in the Department of Nursing, Faculty of Health Sciences, Erzincan University, Turkey. The total number of mothers and sisters in the study sample was 126. The data were collected in two stages, before and one month after family training. IBM SPSS Statistics 22 software package was used for statistical data analysis. The percentage, mean, standard deviation, and Student’s t-test were used for statistical processing. The p-value of 0.05 was considered statistically significant for all tests.
Results. The knowledge level of study participants about breast cancer and BSE was analyzed, and the source of their knowledge was assessed. Applying family training approach showed a significant increase in BSE knowledge level of participants one month after training. It was accompanied by increasing BSE skills and self-esteem levels (according to the mean values of the Rosenberg Self-Esteem Scale).
Conclusions. Training for family members is an effective method to increase women' s knowledge and skills in BSE. In addition, BSE training enabled female students and their families to participate in BSE practice.
The Effect of Preoperative Anxiety on Postoperative Symptoms in Patients Without a History of Anxiety Scheduled for Coronary Artery Bypass Grafting
Authors: Arslan Isik Nurten , Emir Izzet 
Published: September 2022

The aim of this study was to measure the level of preoperative anxiety in patients scheduled for coronary artery bypass grafting (CABG) to assess the relationship between anxiety and postoperative symptoms.
Materials and Methods. This descriptive study was conducted at a single university hospital from February to November 2021. Seventy-four CABG patients who completed the Anxiety Specific to Surgery Questionnaire, the Visual Analogue Scale, the Modified Borg Scale, the Rhodes Index of Nausea, Vomiting and Retching were included in the study. The data were analyzed by the mean, standard deviation, frequency distribution, Mann-Whitney U Test, and Spearman’s correlation analysis.
Results. The average age of participants was 65.55 ± 8.35; 66.2% of them were males. The ASSQ total scores of female participants were significantly higher as compared to male participants (p < 0.05). There was a statistically significant positive relationship between the levels of anxiety in patients before CABG and the levels of postoperative pain and dyspnea severity (p < 0.05).
Conclusions. Patients were found to experience predominantly moderate to severe anxiety before CABG, and increased dyspnea complaints and pain in the postoperative period. A coordinated, multidisciplinary approach to preoperative training of healthcare professionals may offer a promising way to provide more efficient and productive services.