bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model
Authors: Zizmare Laimdota , Mehling Roman , Gonzalez-Menendez Irene , Lonati Caterina , Quintanilla-Martinez Leticia , Pichler Bernd J. , Kneilling Manfred , Trautwein Christoph 
Published: November 2022

AbstractT-cell-driven immune responses are responsible for several autoimmune disorders, such as psoriasis vulgaris and rheumatoid arthritis. Identification of metabolic signatures in inflamed tissues is needed to facilitate novel and individualised therapeutic developments. Here we show the temporal metabolic dynamics of T-cell-driven inflammation characterised by nuclear magnetic resonance spectroscopy-based metabolomics, histopathology and immunohistochemistry in acute and chronic cutaneous delayed-type hypersensitivity reaction (DTHR). During acute DTHR, an increase in glutathione and glutathione disulfide is consistent with the ear swelling response and degree of neutrophilic infiltration, while taurine and ascorbate dominate the chronic phase, suggesting a switch in redox metabolism. Lowered amino acids, an increase in cell membrane repair-related metabolites and infiltration of T cells and macrophages further characterise chronic DTHR. Acute and chronic cutaneous DTHR can be distinguished by characteristic metabolic patterns associated with individual inflammatory pathways providing knowledge that will aid target discovery of specialised therapeutics.
Mitochondria dysfunction impairs Tribolium castaneum wing development during metamorphosis
Authors: Jiao Yaoyu , Palli Subba Reddy 
Published: November 2022

AbstractThe disproportionate growth of insect appendages such as facultative growth of wings and exaggeration of beetle horns are examples of phenotypic plasticity. Insect metamorphosis is the critical stage for development of pupal and adult structures and degeneration of the larval cells. How the disproportionate growth of external appendages is regulated during tissue remodeling remains unanswered. Tribolium castaneum is used as a model to study the function of mitochondria in metamorphosis. Mitochondrial dysfunction is achieved by the knockdown of key mitochondrial regulators. Here we show that mitochondrial function is not required for metamorphosis except that severe mitochondrial dysfunction blocks ecdysis. Surprisingly, various abnormal wing growth, including short and wingless phenotypes, are induced after knocking down mitochondrial regulators. Mitochondrial activity is regulated by IIS (insulin/insulin-like growth factor signaling)/FOXO (forkhead box, sub-group O) pathway through TFAM (transcription factor A, mitochondrial). RNA sequencing and differential gene expression analysis show that wing-patterning and insect hormone response genes are downregulated, while programmed cell death and immune response genes are upregulated in insect wing discs with mitochondrial dysfunction. These studies reveal that mitochondria play critical roles in regulating insect wing growth by targeting wing development during metamorphosis, thus showing a novel molecular mechanism underlying developmental plasticity.
Sound Therapy to Reduce Auditory Gain for Hyperacusis and Tinnitus
Authors: Henry James A. 
Published: November 2022

Purpose:
Hyperacusis is the most common of the different types of sound tolerance conditions. It has been defined as physical discomfort or pain when any sound reaches a certain level of loudness that would be comfortable for most people. Because hyperacusis and tinnitus occur together so often, it has been theorized that they have a common neural mechanism. A leading contender for that mechanism is enhancement of auditory gain. The purpose of this tutorial is to review the evidence that sound/acoustic therapy can reduce auditory gain and, thereby, can increase loudness tolerance for people with hyperacusis and/or suppress the percept of tinnitus.

Method:
The scientific literature was informally reviewed to identify and elucidate relationships between tinnitus, hyperacusis, sound therapy, and auditory gain.

Results:
Evidence exists, both in animal and human studies, that enhanced auditory gain is associated with hyperacusis and tinnitus. Further evidence supports the theory that certain forms of sound therapy can reduce neural hyperactivity, thereby reducing auditory gain. The evidence for sound therapy reducing auditory gain is stronger for hyperacusis than it is for tinnitus.

Conclusions:
Based on results from numerous studies, sound therapy clearly has application as a method of desensitization for hyperacusis. Enhanced auditory gain might be responsible for tinnitus, but other mechanisms have been theorized. A review of the relevant literature leads to the conclusion that some form(s) of sound therapy has the potential to suppress or eliminate tinnitus on a long-term basis. Systematic research is needed to evaluate this premise.
Mapping Meta-Therapy Onto the Treatment of Cognitive-Communication and Language Disorders in Adults
Authors: Tilton-Bolowsky Victoria E. , Davis Alaina S. , Zipse Lauryn 
Published: November 2022

Purpose:
The purpose of this clinical focus article is to explore how the concept of meta-therapy applies within the domain and treatment of cognitive-communication disorders.

Method:
We briefly introduce the concept of meta-therapy, first introduced by Helou (2017), and explore how the concept of meta-therapy may be applied to the treatment of cognitive-communication disorders. Unique aspects of cognitive-communication disorders that might necessitate adaptations and modifications to the clinical dialogues clinicians use in cognitive-communication treatment are discussed. Examples of effective clinical dialogues are provided within each of the five self-referential goals of meta-therapy and contrast these examples with less effective examples. We highlight the importance of considering a multitude of client-specific characteristics (e.g., acuity, disorder etiology, cultural–linguistic background, and personal values) when using these dialogues. We summarize the most essential elements of meta-therapeutic dialogues and discuss common pitfalls that novice clinicians should consider. This clinical focus article ends with a brief overview of relevant and related topics, as well as future directions for applying meta-therapy to the treatment of cognitive-communication disorders.

Conclusions:
There are certain factors inherent to cognitive-communication disorders that may make the effectiveness of meta-therapeutic dialogues within this realm difficult to ensure and measure. However, modifications to these dialogues to accommodate for these factors, such as a client's impaired comprehension or memory, are feasible. We offer potential avenues for further exploration of meta-therapy within the treatment of cognitive-communication disorders.
An approach of measuring velocity based on auto‐correlation in a single frame for IEEE 802.11ad
Authors: Zhao Sudun , Liu Wei , Lei Jing , Lai Ke 
Published: November 2022

AbstractIn this letter, a velocity measurement algorithm based on auto‐correlation in a single frame for IEEE 802.11ad is proposed. The periodicity of the Golay sequences in the preamble is exploited in the algorithm to estimate the time delay and achieve the velocity measurement at the same time. The improved measuring accuracy is obtained as the effect of noise is suppressed by designing and utilizing the auto‐correlation function.
Design of a dual spider‐shaped surface plasmon resonance‐based refractometric sensor with high amplitude sensitivity
Authors: Islam Mohammad Rakibul , Khan Md Moinul Islam , Mehjabin Fariha , Chowdhury Jubair Alam , Islam Mohibul , Yeasir Ahmad Jarif , Mim Jannat Ara , Nahid Tajuddin Ahmed 
Published: November 2022

AbstractThis study presents an investigation on the performance of the sensitivity of a dual spider‐shaped surface plasmon resonance (SPR)‐based photonic crystal fibre (PCF) refractive index sensor having unique design specifications. To evaluate the fibre guiding properties, Finite Element Method is used for utilising the monetarily accessible COMSOL Multiphysics version 5.3a. A gold layer has been used as the plasmonic material surrounding the fibre to ensure chemical stability, and a single fine coating of TiO2 supported the improvement of gold attachment with the fibre. The structural air holes' design arrangement inside the PCF gives an enhanced sensitivity performance. The proposed PCF‐SPR gives extremely reduced confinement losses. Numerous precise investigations on the fibre parameters show the highest amplitude sensitivity of 4233 RIU−1 in detecting the scope of the refractive index (RI) 1.32–1.41. 2.36 × 10−6 and 1.18 × 10−5 and are achieved as amplitude resolution and wavelength resolution, respectively. The highest confinement loss found for this sensor is recorded to be 6.22 dB/cm. The RI sensor can lead to the exact identification of organic chemicals and biological analytes for the proposed design specifications, providing good sensitivity with significantly reduced confinement loss.
Galaxy and Mass Assembly (GAMA)
Authors: Sureshkumar U. , Durkalec A. , Pollo A. , Bilicki M. , Cluver M. E. , Bellstedt S. , Farrow D. J. , Loveday J. , Taylor E. N. , Bland-Hawthorn J. 
Published: November 2022

Aims. We investigate how different mid-infrared (mid-IR) properties of galaxies are correlated with the environment in which the galaxies are located. For this purpose, we first study the dependence of galaxy clustering on the absolute magnitude at 3.4 μm and redshift. Then, we look into the environmental dependence of mid-IR luminosities and the galaxy properties derived from these luminosities. We also explore how various IR galaxy luminosity selections influence the galaxy clustering measurements.
Methods. We used a set of W1 (3.4 μm) absolute magnitude (MW1) selected samples from the Galaxy and Mass Assembly (GAMA) survey matched with mid-IR properties from the Wide-field Infrared Survey Explorer (WISE) in the redshift range 0.07 ≤ z < 0.43. We computed the galaxy two-point correlation function (2pCF) and compared the clustering lengths between subsamples binned in MW1 and in redshift. We also measured the marked correlation function (MCF), in which the galaxies are weighted by marks when measuring clustering statistics, using the luminosities in the WISE W1 to W4 (3.4 to 22 μm) bands as marks. Additionally, we compared the measurements of MCFs with different estimates of stellar mass and star formation rate (SFR) used as marks. Finally, we checked how different selections applied to the sample affect the clustering measurements.
Results. We show strong clustering dependence on the W1 absolute magnitude: galaxies brighter in the W1 band are more strongly clustered than their fainter counterparts. We also observe a lack of significant redshift dependence of clustering in the redshift range 0.07 ≤ z < 0.43. We show that although the W1 and W2 bands are direct indicators of stellar mass, a galaxy sample selected based on W1 or W2 bands does not perfectly show the clustering behaviour of a stellar mass-selected sample. The proxy relation between W3 and W4 bands and SFR is similar. We also demonstrate the influence of estimation techniques of stellar mass and SFR on the clustering measurements.
Ultracool dwarfs in Gaia DR3
Authors: Sarro L. M. , Berihuete A. , Smart R. L. , Reylé C. , Barrado D. , García-Torres M. , Cooper W. J. , Jones H. R. A. , Marocco F. , Creevey O. L. , Sordo R. , Bailer-Jones C. A. L. , Montegriffo P. , Carballo R. , Andrae R. , Fouesneau M. , Lanzafame A. C. , Pailler F. , Thévenin F. , Lobel A. , Delchambre L. , Korn A. J. , Recio-Blanco A. , Schultheis M. S. , De Angeli F. , Brouillet N. , Casamiquela L. , Contursi G. , de Laverny P. , García-Lario P. , Kordopatis G. , Lebreton Y. , Livanou E. , Lorca A. , Palicio P. A. , Slezak-Oreshina I. , Soubiran C. , Ulla A. , Zhao H. 
Published: November 2022

Context. Previous Gaia data releases offered the opportunity to uncover ultracool dwarfs (UCDs) through astrometric, rather than purely photometric, selection. The most recent, the third data release (DR3), offers in addition the opportunity to use low-resolution spectra to refine and widen the selection.
Aims. In this work we use the Gaia DR3 set of UCD candidates and complement the Gaia spectrophotometry with additional photometry in order to characterise the global properties of the set. This includes the inference of the distances, their locus in the Gaia colour-absolute magnitude diagram, and the (biased through selection) luminosity function at the faint end of the main sequence. We study the overall changes in the Gaia RP spectra as a function of spectral type. We study the UCDs in binary systems, we attempt to identify low-mass members of nearby young associations, star-forming regions, and clusters, and we analyse their variability properties.
Methods. We used a forward model and the Bayesian inference framework to produce posterior probabilities for the distribution parameters and a calibration of the colour index as a function of the absolute magnitude in the form of a Gaussian process. Additionally, we applied the hierarchical mode association clustering (HMAC) unsupervised classification algorithm for the detection and characterisation of overdensities in the space of celestial coordinates, projected velocities, and parallaxes.
Results. We detect 57 young, kinematically homogeneous groups, some of which are identified as well-known star-forming regions, associations, and clusters of different ages. We find that the primary members of the 880 binary systems with a UCD belong to the thin and thick disc components of the Milky Way. We identify 1109 variable UCDs using the variability tables in the Gaia archive, 728 of which belong to the star-forming regions defined by HMAC. We define two groups of variable UCDs with extreme bright or faint outliers.
Conclusions. The set of sources identified as UCDs in the Gaia archive contains a wealth of information that will require focused follow-up studies and observations. It will help advance our understanding of the nature of the faint end of the main sequence and the stellar-substellar transition.
Star-forming early-type galaxies and quiescent late-type galaxies in the local Universe
Authors: Paspaliaris E.-D. , Xilouris E. M. , Nersesian A. , Bianchi S. , Georgantopoulos I. , Masoura V. A. , Magdis G. E. , Plionis M. 
Published: November 2022

Aims.The general consensus is that late-type galaxies undergo intense star-formation, activity while early-type galaxies are mostly inactive. We question this general rule and investigate the existence of star-forming early-type and quiescent late-type galaxies in the local Universe. By computing the physical properties of these galaxies and by using information on their structural properties as well as the density of their local environment, we seek to understand the differences from their ‘typical’ counterparts.Methods.We made use of the multi-wavelength photometric data (from the ultraviolet to the sub-millimetre), for 2209 morphologically classified galaxies in the Galaxy And Mass Assembly survey. Furthermore, we separated the galaxies into subsets of star-forming and quiescent based on their dominant ionising process, making use of established criteria based on theWHαwidth and the [NII/Hα] ratio. Taking advantage of the spectral energy distribution fitting codeCIGALE, we derived galaxy properties, such as the stellar mass, dust mass, and star-formation rate, and we also estimated the unattenuated and the dust-absorbed stellar emission, for both the young (≤200 Myr) and old (> 200 Myr) stellar populations.Results.We find that about 47% of E/S0 galaxies in our sample show ongoing star-formation activity and 8% of late-type galaxies are quiescent. The star-forming elliptical galaxies, together with the little blue spheroids, constitute a population that follows the star-forming main sequence of spiral galaxies very well. The fraction of the luminosity originating from young stars in the star-forming early-type galaxies is quite substantial (∼25%) and similar to that of the star-forming late-type galaxies. The stellar luminosity absorbed by the dust (and used to heat the dust grains) is highest in star-forming E/S0 galaxies (an average of 35%) followed by star-forming Sa-Scd galaxies (27%) with this fraction becoming significantly smaller for their quiescent analogues (6% and 16%, for E/S0 and Sa-Scd, respectively). Star-forming and quiescent E/S0 galaxies donate quite different fractions of their young stellar luminosities to heat up the dust grains (74% and 36%, respectively), while these fractions are very similar for star-forming and quiescent Sa-Scd galaxies (59% and 60%, respectively). Investigating possible differences between star-forming and quiescent galaxies, we find that the intrinsic (unattenuated) shape of the SED of the star-forming galaxies is, on average, very similar for all morphological types. Concerning their structural parameters, quiescent galaxies tend to show larger values of ther-band Sérsic index and larger effective radii (compared to star-forming galaxies). Finally, we find that star-forming galaxies preferably reside in lower density environments compared to the quiescent ones, which exhibit a higher percentage of sources being members of groups.
Accuracy of Flash Glucose Monitoring in Hemodialysis Patients With
and Without Diabetes Mellitus
Authors: Weber Michèle R. , Diebold Matthias , Wiesli Peter , Kistler Andreas D. 
Published: November 2022

Abstract
Aims Glucose and insulin metabolism are altered in hemodialysis patients,
and diabetes management is difficult in these patients. We aimed to validate
flash glucose monitoring (FGM) in hemodialysis patients with and without
diabetes mellitus as an attractive option for glucose monitoring not requiring
regular self-punctures.
Methods We measured interstitial glucose using a FreeStyle Libre device in
eight hemodialysis patients with and seven without diabetes mellitus over 14
days and compared the results to simultaneously performed self-monitoring of
capillary blood glucose (SMBG).
Results In 720 paired measurements, mean flash glucose values were
significantly lower than self-measured capillary values (6.17±2.52 vs.
7.15±2.41 mmol/L, p=1.3 E-86). Overall, the mean
absolute relative difference was 17.4%, and the mean absolute difference
was 1.20 mmol/L. The systematic error was significantly larger
in patients without vs. with diabetes (− 1.17 vs.
− 0.82 mmol/L) and on dialysis vs. interdialytic
days (−1.09 vs. −0.90 mmol/L). Compared to
venous blood glucose (72 paired measurements), the systematic error of FGM was
even larger (5.89±2.44 mmol/L vs.
7.78±7.25 mmol/L, p=3.74E-22). Several
strategies to reduce the systematic error were evaluated, including the addition
of +1.0 mmol/L as a correction term to all FGM values,
which significantly improved accuracy.
Conclusions FGM systematically underestimates blood glucose in
hemodialysis patients but, taking this systematic error into account, the system
may be useful for glucose monitoring in hemodialysis patients with or without
diabetes.
Best Practice Recommendations for the Safe use of Lung Ultrasound
Authors: Wolfram Frank , Miller Douglas , Demi Libertario , Verma Prashant , Moran Carmel M , Walther Marcel , Mathis Gebhard , Prosch Helmut , Kollmann Christian , Jenderka Klaus-Vitold 
Published: November 2022

AbstractThe safety of ultrasound is of particular importance when examining the lungs, due to specific bioeffects occurring at the alveolar air-tissue interface. Lung is significantly more sensitive than solid tissue to mechanical stress. The causal biological effects due to the total reflection of sound waves have also not been investigated comprehensively.On the other hand, the clinical benefit of lung ultrasound is outstanding. It has gained considerable importance during the pandemic, showing comparable diagnostic value with other radiological imaging modalities.Therefore, based on currently available literature, this work aims to determine possible effects caused by ultrasound on the lung parenchyma and evaluate existing recommendations for acoustic output power limits when performing lung sonography.This work recommends a stepwise approach to obtain clinically relevant images while ensuring lung ultrasound safety. A special focus was set on the safety of new ultrasound modalities, which had not yet been introduced at the time of previous recommendations.Finally, necessary research and training steps are recommended in order to close knowledge gaps in the field of lung ultrasound safety in the future.These recommendations for practice were prepared by ECMUS, the safety committee of the EFSUMB, with participation of international experts in the field of lung sonography and ultrasound bioeffects.
Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience
Authors: Demir Metin , Güven Denizcan , Aktaş Burak Yasin , Güner Gürkan , Aktepe Oktay Halit , Taban Hakan , Karakaş Yusuf , Kılıçkap Sadettin , Kars Ayşe , Türker Alev , Dizdar Ömer 
Published: November 2022

Abstract
Objective Liposarcomas are relatively rare tumors. Prognostic and predictive factors and treatment options are limited. We herein presented our 10-year experience with liposarcomas.
Materials and Methods Adult patients with liposarcoma treated between 2005 and 2015 in our center were included. Demographic and clinicopathologic features of patients were retrieved from patient files.
Statistical Analyses Outcomes in terms of disease-free survival (DFS) and overall survival (OS) were assessed along with potential prognostic factors using Kaplan–Meier analyses.
Results A total of 88 patients were included. The median age was 52. Rates of well-differentiated (WDLS), dedifferentiated (DDLS), myxoid (MLS), and pleomorphic liposarcomas (PLS) were 42, 9.1, 37.5, and 4.5%, respectively. Only 10% of patients had high-grade tumors and 93% had localized disease. Ninety-six percent of patients (n = 84) underwent surgery. Adjuvant chemotherapy was delivered to 16 patients. The most common regimen was ifosfamide–doxorubicin. Recurrences were observed in 30 patients, 21 had local, and 9 had distant metastasis. Five-year DFS of patients with the localized disease was 68%. All patients with PLS had relapses and those had the highest distant relapse rates among all subtypes. Multivariate analysis showed T stage and grade were associated with DFS. Five-year OS of the entire population was 68%. Five-year OS was 79, 76, 50, and 0% in WDLS, MLS, DDLS, and PLS, respectively (p = 0.002).
Conclusion Management of liposarcomas is still challenging. Surgery is the mainstay of treatment. Novel effective therapies are needed, particularly in advanced disease settings.