bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cancer Stem Cell Potency of Group 10‐Azadiphosphine Metal Complexes
Authors: Xiao Zhiyin , Northcote‐Smith Joshua , Johnson Alice , Singh Kuldip , Suntharalingam Kogularamanan 
Published: August 2022

AbstractThe cancer stem cell (CSC) potency of a series of structurally analogous Group 10‐azadiphosphine metal complexes is reported. The complexes comprise a Group 10 metal (Ni for 1, Pd for 2, or Pt for 3), an azadiphosphine ligand, and two chloride ligands. The complexes exhibit micromolar potency towards bulk breast cancer cells and breast CSCs cultured in monolayer systems. The cytotoxicity of the complexes is comparable to or better than clinically used metallopharmaceuticals, cisplatin and carboplatin, and the gold‐standard anti‐breast CSC agent, salinomycin. Notably, the breast CSC mammosphere inhibitory effect and potency of the complexes is dependent on the Group 10 metal present, increasing in the following order: 3<2<1. This study highlights the importance of the metal within a given series of structurally related compounds to their breast CSC mammosphere activity and reinforces the therapeutic potential of Group 10 coordination complexes as anti‐CSC agents.
Complementary Cooperative Catalytic Systems in the Aerobic Oxidation of a Wide Range of Si−H‐Reagents to Si−OH‐Products: From Monomers to Oligomers and Polymers
Authors: Goncharova Irina K. , Tukhvatshin Rinat S. , Novikov Roman A. , Volodin Alexander D. , Korlyukov Alexander A. , Lakhtin Valentin G. , Arzumanyan Ashot V. 
Published: August 2022

AbstractThe article presents an in‐depth study of the applicability of cooperative [M]‐/Organo‐catalytic systems in aerobic Si−H‐functionalization. A thorough kinetic study allowed us to identify two “complementary” catalytic systems based on earth‐abundant [M]‐catalysts and inexpensive commercially available organic catalysts. The first system, Co(OAc)2/N‐hydroxysuccinimide, made it possible to oxidize a Si−H‐group to a Si−OH‐group in a wide range of monomers, including previously unknown ones, that dramatically differ in their reactivity. However, this system failed in the case of oligomeric and polymeric substrates. This problem was solved by application of the Cu(OAc)2/N‐hydroxyphthalimide system. A wide potential for gram‐scale (50–100 g) preparation of Si−OH‐containing products with molecular architectures of different complexity was revealed using the established “substrate‐reactivity‐catalytic system” relationship. In particular, previously unknown types of dumbbell‐shaped and graft polymers were synthesized using alkoxysilanols.
The Prevalence of Opioids in US Drinking Water Sources Detected Using Direct-Injection High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Authors: Skaggs Christopher S. , Logue Brian A. 
Published: August 2022

Abstract
Active pharmaceutical ingredient (API) contamination of water sources, including opioid contamination, has become more common in recent years. Although drinking water–treatment plants help mitigate API infiltration, API contamination remains in some drinking water sources. Therefore, the ability to detect APIs at ultratrace concentrations is vital to ensure safe drinking water. A method for the ultratrace determination of fentanyl, hydrocodone, and codeine in drinking water via direct injection and high-performance liquid-chromatography tandem mass spectrometry (HPLC-MS/MS) was developed and validated. Drinking water samples (10 ml) are simply syringe-filtered and then analyzed by HPLC-MS/MS. A wide linear range (0.25–100 ng/L) and ultratrace limits of detection (80, 150, and 500 pg/L for fentanyl, hydrocodone, and codeine, respectively) were features of the method. The method produced excellent aggregate accuracies of 90%–115% and precisions of ≤11% for the three analytes tested. This method was used to test drinking water samples from 53 US locations, with hydrocodone and codeine detected in approximately 40% of the samples tested at concentrations between 0.3 and 20 ng/L. Codeine was detected at higher concentrations than hydrocodone (up to 7.3 times) for each sample containing these APIs. Fentanyl was not detected in any field drinking water sample. The detection of opioids in a large fraction of the US drinking water samples tested is cause for concern, and these levels should continue to be monitored to ensure that they do not become a threat to human health. Environ Toxicol Chem 2022;41:2658–2666. © 2022 SETAC
Advances and prospects in the biosynthesis of vitamin B6 and its bioengineering as a cofactor of other chemicals
Authors: Wu Lijuan , Liu Linxia , Jin Zhaoxia , Zhang Dawei 
Published: August 2022

AbstractVitamin B6 is an essential nutrient, which is widely used in food products, feed additives, pharmaceuticals, disease diagnosis, and other fields. Pyridoxal‐5′‐phosphate (PLP), the active form of vitamin B6, is an important coenzyme participating in a variety of enzyme reactions. At present, the oxazole method is mainly used for the production of vitamin B6, but toxic and corrosive intermediates produced in the synthesis process, which does not conform to the green manufacturing. Therefore, there is considerable interest in shifting from chemical processes to sustainable fermentation techniques and research on PLP metabolism of other valuable compounds. In this review, we will briefly describe the enzymes that PLP participated and focus on the advances in vitamin B6 biosynthesis and discuss its application to engineering bacteria that overproduce other commercially valuable substances including cadaverine, 3,4‐dihydroxyphenylacetate‐l‐alanine, γ‐aminobutyric acid, and l‐phosphinothricin. It will provide a reference for the biosynthesis of vitamin B6 or other valuable compounds in which PLP participates in the reaction, and we also look forward to the future development prospect of PLP.
Salivary bypass tube in total laryngectomy: Systematic review and meta‐analysis
Authors: Costantino Andrea , Pace Gian Marco , Festa Bianca Maria , Ferreli Fabio , Malvezzi Luca , Spriano Giuseppe , Mercante Giuseppe , De Virgilio Armando 
Published: August 2022

AbstractThe aim of this study is to determine whether the preventive positioning of a salivary bypass tube (SBT) after total laryngectomy (TL) reduces the incidence of postoperative pharyngocutaneous fistula (PCF) and pharyngeal stenosis (PS). This study was conducted in conformity with the PRISMA statement. 1960 patients with a median age of 62.0 years were included. A SBT was placed in 980 (50%) patients (SBT group). The cumulative PCF incidence in the SBT group was 15.8% (95% CI: 9.3–23.6). The measured pooled OR comparing PCF incidence in patients with SBT compared to those without was 0.40 (95% CI: 0.24–0.65). The pooled PS incidence in the SBT group was 12.3% (95% CI: 5.4–21.6). The measured pooled OR comparing PS incidence in patients with SBT compared to those without was 0.43 (95% CI: 0.24–0.65). PCF and PS could be prevented by the intra‐operative placement of a SBT.
Thirteen cancers associated with HIV infection in a Black South African cancer patient population (1995‐2016)
Authors: Sengayi‐Muchengeti Mazvita , Singh Elvira , Chen Wenlong Carl , Bradshaw Debbie , de Villiers Chantal Babb , Newton Robert , Waterboer Tim , Mathew Christopher G , Sitas Freddy 
Published: August 2022

AbstractSouth Africa's HIV epidemic has evolved over time in terms of numbers of people living with HIV, access to antiretroviral treatment (ART) and age. These changes have profoundly influenced local cancer patterns. The Johannesburg Cancer Study has, over a period of 22 years (1995‐2016), recruited over 20 000 incident black cancer patients who consented to provide answers to a questionnaire and blood samples (serum, DNA). This has presented a unique opportunity to examine the evolving association of HIV with cancer in Africa. We used logistic regression models to explore case‐control associations between specific cancers and HIV, using participants with non‐infection related cancers as controls. Using data of 20 835 cancer patients with confirmed HIV status, we found the following cancers to be associated with HIV: Kaposi's sarcoma (ORadj; 95%CI): (99.1;72.6‐135.1), non‐Hodgkin lymphoma (11.3;9.3‐13.6), cervical cancer (2.7;2.4‐3.0), Hodgkin lymphoma (3.1;2.4‐4.2), cancer of the eye/conjunctiva (18.7;10.1‐34.7), anogenital cancers (anus [2.1;1.4‐3.2], penis [5.4;2.7‐10.5], vulva [4.8;3.5‐6.4], vagina [5.5;3.0‐10.2]), oropharyngeal cancer (1.6;1.3‐1.9), squamous cell carcinoma of the skin (3.5;2.4‐4.9), melanoma (2.0;1.2‐3.5) and cancer of the larynx (1.7;1.3‐2.4). Kaposi's sarcoma odds ratios increased from the pre‐ART (1995‐2004) to the early ART (2005‐2009) period but declined in the late ART (2010‐2016) period. Odds ratios for cancers of the eye/conjunctiva, cervix, penis and vulva continued to increase in recent ART periods. Our study confirms the spectrum of HIV‐associated cancers found in other African settings. The odds ratios of conjunctival and HPV‐related cancers continue to rise in the ART era as the HIV positive population ages.
Stabilization of Zn group dimers: A theoretical study
Authors: Borah Ritam R. , Deka Rinu P. 
Published: August 2022

AbstractQuantum chemical calculations have been carried out to investigate the possibility of Group 12 (Zn, Cd, Hg) dimer formation supported by the B3ring. All these complexes have significantly shorter M‐M (M = Zn, Cd, Hg) distances compared to their bare dimers, M2. The staggered and eclipsed forms of these complexes were found to be nearly degenerate. They have significant bond strengths as revealed from the significantly higher values of Wiberg bond indices as well as bond dissociation energies. The topological feature of electron density reveals significant covalency in the M‐M interaction which has also been confirmed from natural orbital for chemical valence analysis coupled with extended transition state (ETS‐NOCV) calculations.
Age‐Related Differences of Cortical Topology Across the Adult Lifespan: Evidence From a Multisite MRI Study With 1427 Individuals
Authors: Wang Yin , Zhang Yinghui , Zheng Weihao , Liu Xia , Zhao Ziyang , Li Shan , Chen Nan , Yang Lin , Fang Lei , Yao Zhijun , Hu Bin 
Published: August 2022

BackgroundHealthy aging is usually accompanied by alterations in brain network architecture, influencing information processing and cognitive performance. However, age‐associated coordination patterns of morphological networks and cognitive variation are not well understood.PurposeTo investigate the age‐related differences of cortical topology in morphological brain networks from multiple perspectives.Study TypeProspective, observational multisite study.PopulationA total of 1427 healthy participants (59.1% female, 51.75 ± 19.82 years old) from public datasets.Field Strength/Sequence1.5 T/3 T, T1‐weighted magnetization prepared rapid gradient echo (MP‐RAGE) sequence.AssessmentThe multimodal parcellation atlas was used to define regions of interest (ROIs). The Jensen‐Shannon divergence‐based individual morphological networks were constructed by estimating the interregional similarity of cortical thickness distribution. Graph‐theory based global network properties were then calculated, followed by ROI analysis (including global/nodal topological analysis and hub analysis) with statistical tests.Statistical TestsChi‐square test, Jensen–Shannon divergence‐based similarity measurement, general linear model with false discovery rate correction. Significance was set at P < 0.05.ResultsThe clustering coefficient (q = 0.016), global efficiency (q = 0.007), and small‐worldness (q = 0.006) were significantly negatively quadratic correlated with age. The group‐level hubs of seven age groups were found mainly distributed in default mode network, visual network, salient network, and somatosensory motor network (the sum of these hubs' distribution in each group exceeds 55%). Further ROI‐wise analysis showed significant nodal trajectories of intramodular connectivities.Data ConclusionThese results demonstrated the age‐associated reconfiguration of morphological networks. Specifically, network segregation/integration had an inverted U‐shaped relationship with age, which indicated age‐related differences in transmission efficiency.Evidence Level2Technical EfficacyStage 1
Clinical characteristics, outcomes, and seasonality of acute respiratory infection associated with single and codetected rhinovirus species among hospitalized children in Amman, Jordan
Authors: Talj Rana , Amarin Justin Z. , Rankin Danielle A. , Bloos Sean M. , Shawareb Yanal , Rahman Herdi , Haddadin Zaid , Howard Leigh M. , Probst Varvara , Naffa Randa G. , Johnson Monika , Lane Sidney , Kinzler Amy J. , Spieker Andrew J. , Faouri Samir , Shehabi Asem , Chappell James , Khuri‐Bulos Najwa , Williams John V. , Halasa Natasha 
Published: August 2022

AbstractRhinovirus (RV)‐specific surveillance studies in the Middle East are limited. Therefore, we aimed to study the clinical characteristics, outcomes, and seasonality of RV‐associated acute respiratory infection among hospitalized young children in Jordan. We conducted a prospective viral surveillance study and enrolled children <2 years old admitted to a large public hospital in Amman, Jordan (2010–2013). Demographic and clinical data were collected by structured interviews and chart abstractions. Nasal and/or throat swabs were collected and tested for a panel of respiratory viruses, and RV genotyping and speciation was performed. At least one virus was detected in 2641/3168 children (83.4%). RV was the second most common virus detected (n = 1238; 46.9%) and was codetected with another respiratory virus in 730 cases (59.0%). Children with RV codetection were more likely than those with RV‐only detection to have respiratory distress but had similar outcomes. RV‐A accounted for about half of RV‐positive cases (54.7%), while children with RV‐C had a higher frequency of wheezing and reactive airway disease. RV was detected year‐round and peaked during winter. In conclusion, though children with RV codetection had worse clinical findings, neither codetection nor species affected most clinical outcomes.
Understanding of the interaction of biological macromolecules with lipids using vibrational sum‐frequency generation spectroscopy
Authors: Sarkar Sunipa , Bisoi Asim , Singh Prashant Chandra 
Published: August 2022

AbstractInterfacial water associated with phospholipids plays an important role in different biological processes such as fibrillation of disordered protein, neurotransmitter interaction with lipids, and hydrated proton translocation. However, understanding the structural change of interfacial water and phospholipids during these biological processes is difficult due to the lack of appropriate selective technique and soft nature of these interfaces. Vibrational sum‐frequency generation (VSFG) is a second‐order nonlinear spectroscopic technique, which has the inherent surface selectivity as well as sensitivity and hence has been utilized to understand the properties of interfaces. In this review, the utilization of VSFG technique has been discussed in understanding the structural change of interfacial water and lipids during several biological processes.
Long‐Term Outcomes of End‐Flexible‐Rigidscopic Transoral Surgery for Pharyngolaryngeal Cancer
Authors: Watanabe Yoshiki , Tanaka Shinzo , Hasebe Koki , Hiratsuka Yasuyuki , Yoshida Takao , Kusano Junko , Hori Shusei , Okamura Kana , Tanaka Chisato , Fujikawa Shiori , Osada Yuka , Minoyama Manabu 
Published: August 2022

ObjectiveEnd‐flexible‐rigidscopic transoral surgery (E‐TOS) is a new and minimally invasive transoral surgery for resection of Tis‐selected T3 pharyngolaryngeal cancers. We evaluated long‐term oncological outcomes and whether postoperative voice and swallowing function were preserved following E‐TOS.MethodsIn this retrospective single‐center study, 154 patients treated with E‐TOS using a curved retractor, flexible‐tip rigid endoscope, and thin curved instruments were included. Their survival rate, larynx preservation rate, and disease control rate were estimated using the Kaplan–Meier method. Postoperative voice function was evaluated using both objective and subjective tests. Postoperative swallowing function was assessed using the Hyodo score and the functional outcome swallowing scale.ResultsThe 3‐year and 5‐year overall survival, disease‐specific survival, disease‐free survival, laryngectomy‐free survival, local control, and loco‐regional control rates post E‐TOS were 89.8% and 82.2%, 95.6% and 92.3%, 78.5% and 70.3%, 87.2% and 80.9%, 93.9% and 92.5%, and 87.2% and 85.7%, respectively. Both objective and subjective postoperative voice and swallowing function tests were within normal limits in more than 90% of the patients.ConclusionE‐TOS is an effective, safe, low‐cost, and minimally invasive transoral surgery for Tis‐selected T3 pharyngolaryngeal cancer; it also preserves postoperative voice, larynx, and swallowing function.Level of Evidence4 Laryngoscope, 133:1415–1424, 2023
Monopolar Electrosurgery With Cochlear Implants
Authors: Cass Nathan D. , Lindquist Nathan R. , Bennett Marc L. , Haynes David S. 
Published: August 2022

ObjectiveTo evaluate safety of monopolar electrosurgery (MES) in patients with cochlear implants (CIs) by reporting outcomes of a series of patients who underwent MES after CI.Study DesignRetrospective case series.SettingTertiary referral center.PatientsPatients with indwelling CI subsequently undergoing surgery with operative note specifically detailing MES use.Main Outcome MeasuresAdverse outcomes in post‐operative audiology/otolaryngology documentation; speech recognition scores.ResultsThirty‐five patients (10 with bilateral CI) experienced 63 unique MES exposure events, 85.7% below and 14.3% above the clavicle. No adverse events or decreased performance due to MES use were reported for any patient. Pre‐ and immediate postoperative speech recognition scores were not significantly different for patients using either consonant‐nucleus‐consonant (CNC; n = 23, 68%–66%, p = 0.80) or AzBio (n = 15, 82%–88%, p = 0.60). For individual CNC performance, 21 (91%) patients demonstrated stability, 1 improved >15%, and 1 declined >15%, although this patient had become a non‐user due to magnet issues and, after resolution of these issues, exceeded baseline pre‐operative score. For individual AzBio performance, 12 (80%) patients demonstrated stability, 3 improved >15%, and none declined >15%.ConclusionsNo adverse events resulted from MES use in CI patients. Given the increased prevalence and expansion of indications for CIs, and widespread utility of MES, we suggest clarification and improved guidance from device manufacturers regarding safety and use of MES for patients with these devices. We hope that data regarding electrosurgery exposure events will better inform clinician decision‐making with regards to relative benefits and risks for MES use for CI patients.Level of Evidence4 Laryngoscope, 133:933–937, 2023
A Systematic Review of the Spectrum and Prevalence of Non‐Motor Symptoms in Adults with Hereditary Cerebellar Ataxias
Authors: Malek Naveed , Makawita Chulika , Al‐Sami Yaqub , Aslanyan Aram , de Silva Rajith 
Published: August 2022

ABSTRACTBackgroundCerebellar ataxias comprise a large group of heterogeneous disorders with both motor and non‐motor symptoms (NMS).ObjectiveWe wanted to ascertain the reported prevalence of NMS in different subtypes of hereditary cerebellar ataxias.MethodsSystematic review of studies of hereditary cerebellar ataxias (involving >5 patients) who were assessed for NMS, published in the English literature in PUBMED and EMBASE databases from 1947 to 2021.ResultsA total of 35 papers, with data from 1311 autosomal dominant spinocerebellar ataxia (SCA), 893 autosomal recessive cerebellar ataxia (ARCA), and 53 X‐linked ataxia cases were included with a total of 450 controls. Mean age for SCA cases at diagnosis was 47.6 (SD, 14.9) years, for ARCA cases was 34.6 (SD, 14.7) years and for X‐linked ataxia cases was 68.6 (9.1) years. The prevalence of cognitive problems in SCAs was between 23% and 75% (ranging from mild to severe), being least prevalent in SCA6. The prevalence of depression in SCAs was between 13% and 69% and sleep disorders were between 7% and 80%. Pain was reported by 18% to 60% of patients, especially in SCA3, and fatigue by 53% to 70%. The prevalence of reported cognitive dysfunction in ARCA was 12.5% to 100% and depression between 14% and 51%. The prevalence of anxiety in X‐linked ataxias (FXTAS) was 17 % and depression 55%.ConclusionsThe presence of NMS in hereditary cerebellar ataxias is common. The prevalence and spectrum of NMS in SCAs, ARCAs, and X‐linked ataxias vary. In routine clinical practice, NMS in cerebellar ataxias are under‐recognized and certainly under‐reported. Therefore, they are unlikely to be addressed adequately. Improved ascertainment of NMS in cerebellar ataxias in clinical practice will enable holistic treatment of these patients.
Dynamical analysis of rational and semi‐rational solution for a new extended (3 + 1)‐dimensional Kadomtsev‐Petviashvili equation
Authors: Li Lingfei , Yan Yongsheng , Xie Yingying 
Published: August 2022

This paper proposes a new extended (3 + 1)‐dimensional Kadomtsev‐Petviashvili equation that portrays a unique dispersion effect about
. Its integrability is confirmed via the WTC‐Kruskal algorithm in Painlevé sense.
‐soliton, breather, and
‐type solitary wave are derived systematically at first. Then, the mixed solution composed of soliton and breather is obtained. In addition, the “long wave” limit is employed to construct rational and semi‐rational solution. The rational solution can be classified as rogue wave,
‐type solitary wave, and lump wave. The semi‐rational solution has the form a hybrid of two solitons, a hybrid of rogue wave and soliton, a hybrid of lump and soliton(s), and a hybrid of lump and breather. The results may help simulate complex waves and their interactions in fluid.
Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice
Authors: Wang Qianqian , Shen Fei , Zhang Junhui , Cai Haiying , Pan Ya , Sun Tengjia , Gong Yihang , Du Juan , Zhong Hao , Feng Fengqin 
Published: August 2022

ScopeWheat peptides (WP) are rich in glutamic acid, glutamine, and other bioactive compounds that may benefit gut function and health. This study aims to evaluate the effects of regular consumption of WP on constipation‐induced complications and gut microbiota in humans and mice.Methods and resultsA randomized trial of 49 functional constipation participants is conducted. The weekly amount of spontaneous bowel movements (SBM) increases by 2.09 per week after WP treatment, and by 0.40 per week among the placebo group (PL). Concomitantly, the secondary outcomes show significant improvements in the quality of life‐related to constipation (PAC‐QOL), constipation severity, and satisfaction with the intervention. In the animal study, WP effectively alleviates constipation symptoms and affects the secretion of intestinal mobility‐related neurotransmitters and gastrointestinal hormones in loperamide‐induced constipation mice. Additionally, WP regulates the gene and protein expression levels of water‐electrolyte metabolism and intestinal mobility. Furthermore, WP treatment decreases the abundance of several gut microbiota positively correlated to constipation (Turicibacter, Bacteroides_f_Bacteroidaceae, and Streptococcus) in mice.ConclusionWP ameliorates constipation in humans and mice, which could be partly explained by improving water‐electrolyte metabolism, boosting intestinal motility, and reshaping gut microbiota.