bluuebunny/crossref_metadata_2025_split huggingface dataset:
AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer
Authors: Hung Ming-Chun , Wang Wan-Ping , Chi Ya-Hui 
Published: August 2022

Abstract
Background
Constitutive activation of PI3K signaling has been well recognized in a subset of small cell lung cancer (SCLC), the cancer type which has the most aggressive clinical course amongst pulmonary tumors. Whereas cancers that acquire a mutation/copy gain in PIK3CA or loss of PTEN have been implicated in enhanced sensitivity to inhibitors targeting the PI3K/AKT/mTOR pathway, the complexities of the pathway and corresponding feedback loops hamper clear predictions as to the response of tumors presenting these genomic features.

Methods
The correlation between the expression profile of proteins involved in the PI3K/AKT/mTOR signaling and cell viability in response to treatment with small molecule inhibitors targeting isoform-specific PI3Ks, AKT, and mTOR was assessed in 13 SCLC cancer cell lines. Athymic nude mice were used to determine the effect of PI3K/mTOR dual inhibition on the growth of xenograft SCLC tumors in vivo. The activation of caspase signaling and proteolytic cleavages of mTOR companion proteins were assessed using recombinant caspases assays and Western blot analyses.

Results
Our results indicate that the sensitivity of these SCLC cell lines to GSK2126458, a dual PI3K/mTOR inhibitor, is positively correlated with the expression levels of phosphorylated AKT (p-AKT) at Thr308 and Ser473. Inhibition of pan-class I PI3Ks or PI3K/mTOR dual inhibition was shown to induce proteolytic cleavage of RICTOR and RPTOR, which were respectively dependent on Caspase-6 and Caspase-3. A combination of a clinically approved PI3Kα-selective inhibitor and an mTORC1 inhibitor was shown to have synergistic effects in inducing the death of SCLC cells with high p-AKT. We observed no clear correlation between PTEN levels and the survival of SCLCs in response to PI3K/mTOR dual inhibition; however, PTEN depletion was shown to increase the susceptibility of low p-AKT SCLC cells to dual PI3K/mTOR inhibitor-induced cell death as well as the proteolytic cleavage of RICTOR.

Conclusions
These results suggest the level of p-AKT can be a companion diagnostic biomarker for the treatment of SCLC involving the combinational use of clinically approved isoform-specific PI3K and mTOR inhibitors.
Infected pancreatic necrosis complicating severe acute pancreatitis in critically ill patients: predicting catheter drainage failure and need for necrosectomy
Authors: Garret Charlotte , Douillard Marion , David Arthur , Péré Morgane , Quenehervé Lucille , Legros Ludivine , Archambeaud Isabelle , Douane Frédéric , Lerhun Marc , Regenet Nicolas , Gournay Jerome , Coron Emmanuel , Frampas Eric , Reignier Jean 
Published: August 2022

Abstract
Background
Recent guidelines advocate a step-up approach for managing suspected infected pancreatic necrosis (IPN) during acute pancreatitis. Nearly half the patients require secondary necrosectomy after catheter drainage. Our primary objective was to assess the external validity of a previously reported nomogram for catheter drainage, based on four predictors of failure. Our secondary objectives were to identify other potential predictors of catheter-drainage failure. We retrospectively studied consecutive patients admitted to the intensive care units (ICUs) of three university hospitals in France between 2012 and 2016, for severe acute pancreatitis with suspected IPN requiring catheter drainage. We assessed drainage success and failure rates in 72 patients, with success defined as survival without subsequent necrosectomy and failure as death and/or subsequent necrosectomy required by inadequate improvement. We plotted the receiver operating characteristics (ROC) curve for the nomogram and computed the area under the curve (AUROC).

Results
Catheter drainage alone was successful in 32 (44.4%) patients. The nomogram predicted catheter-drainage failure with an AUROC of 0.71. By multivariate analysis, catheter-drainage failure was independently associated with a higher body mass index [odds ratio (OR), 1.12; 95% confidence interval (95% CI), 1.00–1.24; P = 0.048], heterogeneous collection (OR, 16.7; 95% CI, 1.83–152.46; P = 0.01), and respiratory failure onset within 24 h before catheter drainage (OR, 18.34; 95% CI, 2.18–154.3; P = 0.007).

Conclusion
Over half the patients required necrosectomy after failed catheter drainage. Newly identified predictors of catheter-drainage failure were heterogeneous collection and respiratory failure. Adding these predictors to the nomogram might help to identify patients at high risk of catheter-drainage failure.
ClinicalTrials.gov number: NCT03234166.
Blow-up of solution to semilinear wave equations with strong damping and scattering damping
Authors: Ming Sen , Du Jiayi , Su Yeqin , Xue Hui 
Published: August 2022

AbstractThis paper is devoted to investigating the initial boundary value problem for a semilinear wave equation with strong damping and scattering damping on an exterior domain. By introducing suitable multipliers and applying the test-function technique together with an iteration method, we derive the blow-up dynamics and an upper-bound lifespan estimate of the solution to the problem with power-type nonlinearity $|u|^{p}$

|
u
|

p

, derivative-type nonlinearity $|u_{t}|^{p}$

|

u
t

|

p

, and combined type nonlinearities $|u_{t}|^{p}+|u|^{q}$

|

u
t

|

p

+

|
u
|

q

in the scattering case, respectively. The novelty of the present paper is that we establish the upper-bound lifespan estimate of the solution to the problem with strong damping and scattering damping, which are associated with the well-known Strauss exponent and Glassey exponent.
The number of risk factors increases the recurrence events in ischemic stroke
Authors: Juli Cep , Heryaman Henhen , Arnengsih  , Ang Eng-Tat , Defi Irma Ruslina , Gamayani Uni , Atik Nur 
Published: August 2022

Abstract
Purpose
Stroke is a significant cause of disability worldwide and is considered a disease caused by long-term exposure to lifestyle-related risk factors. These risk factors influence the first event of stroke and recurrent stroke events, which carry more significant risks for more severe disabilities. This study specifically compared the risk factors and neurological outcome of patients with recurrent ischemic stroke to those who had just experienced their first stroke among patients admitted to the Hospital.

Patients and methods
We observed and analyzed 300 patients’ data who met the inclusion and exclusion criteria. This retrospective observational study was conducted on consecutive acute ischemic stroke patients admitted to the top referral hospital, West Java, Indonesia. The data displayed are epidemiological characteristics, NIHSS score at admission and discharge, and the type and number of risk factors. Data were then analyzed using appropriate statistical tests.

Results
Most patients had more than one risk factor with hypertension as the most frequent (268 subjects or 89.3%). In patients who experienced ischemic stroke for the first time, the average National Institutes of Health Stroke Scale (NIHSS) score was lower (6.52 ± 3.55), and the alteration of NIHSS score was higher (1.22 ± 2.26) than those with recurrent stroke (6.96 ± 3.55) for NIHSS score and 1.21 ± 1.73 for alteration of NIHSS score). We processed the data with statistical analysis and showed a positive correlation between age (P < 0.05) and the number of risk factors (P < 0.001) in the recurrent ischemic stroke group.

Conclusions
Age and the number of risk factors correlate with recurrent ischemic strokes.
Assessing and projecting surface air temperature conditions required to sustain permafrost in Japan
Authors: Yokohata Tokuta , Iwahana Go , Saito Kazuyuki , Ishizaki Noriko N. , Matsushita Taiga , Sueyoshi Tetsuo 
Published: August 2022

AbstractPermafrost covers a wide area of the Northern Hemisphere, including high-altitude mountainous areas and even at mid-latitudes. There is concern that the thawing of mountain permafrost can cause slope instability and substantially impact alpine ecosystems, and because permafrost in mountainous areas is difficult to observe, detailed analyses have not been performed on its current distribution and future changes. Although previous studies have observed permafrost only at a limited number of points in Japan (e.g., Daisetsu Mountains, Mt. Fuji, and Mt. Tateyama in the Northern Japan Alps), we show that permafrost potentially exists in nine domains in Japan (Daisetsu Mountains, Mt. Fuji, Northern and Southern Japan Alps, Hidaka Mountains, Mt. Shiretokodake, Sharidake, Akandake, and Yotei). In the Daisetsu Mountains and Mt. Fuji, the environmental conditions required for maintaining at least some permafrost are projected to remain in the future if a decarbonized society is achieved (RCP2.6 or RCP4.5). However, if greenhouse gas emissions continue to increase (RCP8.5), the environmental conditions required for sustaining permafrost are projected to disappear in the second half of the twenty-first century. In other domains, the environmental conditions required for maintaining permafrost are either projected to disappear in the next ten years (Hidaka Mountains, Northern Japan Alps) or they have almost disappeared already (Southern Japan Alps, Mt. Shiretokodake, Sharidake, Akandake, and Yotei). Our projections show that climate change has a tremendous impact on Japan's mountain permafrost environment and suggests the importance of monitoring the mountain environment and considering measures for adapting to future climate change.
Analyzing the 27 July 2021 rainfall-induced catastrophic landslide event in the Kutupalong Rohingya Camp in Cox’s Bazar, Bangladesh
Authors: Kamal A. S. M. Maksud , Hossain Farhad , Ahmed Bayes , Sammonds Peter 
Published: August 2022

AbstractThis article critically investigates a catastrophic rainfall-induced landslide event that occurred on 27 July 2021 in the Kutupalong Rohingya Camp (KRC) in Cox’s Bazar, Bangladesh, from geological and geomorphological perspectives. Large-scale anthropogenic interventions mainly caused the disastrous landslide event in the KRC in addition to intense rainfall. Before the landslide occurrence, about 300 mm of cumulative rainfall was recorded in the previous seven days and 120 mm of rainfall during the landslide event. A preliminary investigation was conducted to understand the extent, causative factors, and landslide characteristics. The landslide is of mud-flow type, but on the nearby slope, slumping was also visible. The landslide length was about 33 m, width 31 m, and area 612 m2. The approximate volume of slope materials displaced during the landslide event was about 2450 m3. The displaced slope materials mainly were silt and sand. The landslide event caused five fatalities and damaged nearly 5000 shelters in the KRC area. The devastation from such a small landslide event was attributed to dense households on the slope’s hilltop, slope, and toe. The camp areas and host communities are subjected to frequent and fatal landslides in the years to come due to intense human interventions and climatic conditions. The modifications of the slopes have been reducing the cohesion and the shear strength of the slope materials. Therefore, it is recommended to undertake proper mitigation and preparedness measures, including developing and implementing a landslide early warning system to address the emerging humanitarian crisis in the KRC and its surroundings.
Intrapulmonary solitary fibrous tumor coexisting with lung adenocarcinomas
Authors: Kuroki Shoei , Ayabe Takanori , Gi Toshihiro , Sato Yuichiro , Nakada Hiroshi , Maeda Ryo 
Published: August 2022

Abstract
Background
Solitary fibrous tumor (SFT) is a rare tumor of mesenchymal origin and accounts for < 2% of all soft tissue masses. Although SFT has been identified in multiple anatomic locations and can grow anywhere in the body, intrapulmonary SFT are rare.

Case presentation
In this report, we presented a rare case of intrapulmonary solitary fibrous tumor (SFT) coexisting with lung adenocarcinoma in a 74-year-old man. Chest computed tomography showed a well-defined nodule with punctate calcification and measuring 2.3 × 2.1 cm and two ground-grass nodules with solid component. To obtain a definitive diagnosis and achieve complete resection, surgery was performed. The postoperative diagnosis was intrapulmonary SFT coexisting with lung adenocarcinoma. After surgery, he survived for 6 months without any signs of recurrence.

Conclusion
Complete resection may be the best treatment for intrapulmonary SFT. Careful follow-up of the postoperative course is important, because differentiating between benignity and malignancy is difficult by histologic findings alone.
Coordination of Oral Anticoagulant Care at Hospital Discharge (COACHeD): protocol for a pilot randomised controlled trial
Authors: Holbrook Anne M. , Vidug Kristina , Yoo Lindsay , Troyan Sue , Schulman Sam , Douketis James , Thabane Lehana , Giilck Stephen , Koubaesh Yousery , Hyland Sylvia , Keshavjee Karim , Ho Joanne , Tarride Jean-Eric , Ahmed Amna , Talman Marianne , Leonard Blair , Ahmed Khursheed , Refaei Mohammad , Siegal Deborah M. 
Published: August 2022

Abstract
Background
Oral anticoagulants (OACs) are commonly prescribed, have well-documented benefits for important clinical outcomes but have serious harms as well. Rates of OAC-related adverse events including thromboembolic and hemorrhagic events are especially high shortly after hospital discharge. Expert OAC management involving virtual care is a research priority given its potential to reach remote communities in a more feasible, timely, and less costly way than in-person care. Our objective is to test whether a focused, expert medication management intervention using a mix of in-person consultation and virtual care follow-up, is feasible and effective in preventing anticoagulation-related adverse events, for patients transitioning from hospital to home.

Methods and analysis
A randomized, parallel, multicenter design enrolling consenting adult patients or the caregivers of cognitively impaired patients about to be discharged from medical wards with a discharge prescription for an OAC. The interdisciplinary multimodal intervention is led by a clinical pharmacologist and includes a detailed discharge medication reconciliation and management plan focused on oral anticoagulants at hospital discharge; a circle of care handover and coordination with patient, hospital team and community providers; and early post-discharge follow-up virtual medication check-up visits at 24 h, 1 week, and 1 month. The control group will receive usual care plus encouragement to use the Thrombosis Canada website.
The primary feasibility outcomes include recruitment rate, participant retention rates, trial resources management, and the secondary clinical outcomes include adverse anticoagulant safety events composite (AASE), coordination and continuity of care, medication-related problems, quality of life, and healthcare resource utilization. Follow-up is 3 months.

Discussion
This pilot RCT tests whether there is sufficient feasibility and merit in coordinating oral anticoagulant care early post-hospital discharge to warrant a full sized RCT.

Trial registration
NCT02777047.
In vitro evaluation of antibacterial nanomaterial-induced anaphylactoid reaction for indwelling catheters
Authors: Umeda Koji , Tachikawa Masaji , Azuma Yoshinao , Furuzono Tsutomu 
Published: August 2022

Abstract
Background
To prevent tunnel infection of indwelling catheters, impregnation with antiseptics or antibiotics is effective. However, 13 patients using chlorhexidine–silver sulfadiazine-impregnated catheters experienced serious anaphylactic shock in Japan. Thus, it is necessary to select a suitable evaluation method for allergic reactions and develop a novel antibacterial coating material that does not cause anaphylactic reaction.

Methods
Two types of highly dispersible and antibacterial nanoparticles—fluorine (F)-doped hydroxyapatite (HAp) and zinc (Zn)-doped HAp—were tested using of the system and compared with compound 48/80 (c48/80) as a histamine releaser and chlorhexidine gluconate (CHG) as an anaphylactic inducer.

Results
The histamine concentrations secreted from HMC-1 cells remained mostly the same even with the addition of F-HAp and Zn-HAp. On the contrary, the levels of the chemical mediators from the cells by the addition of F-HAp and Zn-HAp were significantly lower than those of only c48/80 and CHG without the addition of HAp.

Conclusions
The assay was a well-evaluated method for quantifying histamine concentrations released from HMC-1 cells. Our study induced HMC-1 cells accompanied with and without the nanomaterials; the potential of F-HAp and Zn-HAp to induce allergic reactions was found to be quite low. Therefore, the antibacterial nanomaterials are expected to hardly induce anaphylactoid reactions.
Context modulates the impact of auditory information on visual anticipation
Authors: Cañal-Bruland Rouwen , Meyerhoff Hauke S. , Müller Florian 
Published: August 2022

AbstractResearch on the impact of auditory information on visual anticipation in tennis suggests that the intensity of racket-ball-contact sounds systematically biases estimates of the ball’s speed, thereby influencing anticipatory judgments. Here we examined whether the effect of auditory information on visual anticipation is dependent on the sport-specific context in two separate experiments. In Exp. 1, participants watched short videos of tennis rallies that were occluded at racket-ball-contact. Racket-ball-contact sounds of the final shot were either present or absent. Participants faced different tasks in two counterbalanced blocks: In one block they estimated the ball’s speed; in the other block they indicated the ball’s landing location. Results showed that participants estimated longer ball flight trajectories and higher ball speeds in the sound present condition than in the sound absent condition. To probe whether this effect is dependent on the sport-specific context, Exp. 2 introduced an abstract (i.e., context-free) version of the previous stimuli. Based on the ball locations in the original videos used in Exp. 1, we rendered new videos that displayed only a moving circle against a blank background. Sine tones replaced the original racket-ball contact sounds. Results showed no impact of sound presence on location anticipation judgments. However, similar to Exp. 1, object speeds were judged to be faster when the final sound was present. Together, these findings suggest that the impact of auditory information on anticipation does not seem to be driven by sound alone, but to be moderated by contextual information.
On building machine learning pipelines for Android malware detection: a procedural survey of practices, challenges and opportunities
Authors: Mehrabi Koushki Masoud , AbuAlhaol Ibrahim , Raju Anandharaju Durai , Zhou Yang , Giagone Ronnie Salvador , Shengqiang Huang 
Published: August 2022

AbstractAs the smartphone market leader, Android has been a prominent target for malware attacks. The number of malicious applications (apps) identified for it has increased continually over the past decade, creating an immense challenge for all parties involved. For market holders and researchers, in particular, the large number of samples has made manual malware detection unfeasible, leading to an influx of research that investigate Machine Learning (ML) approaches to automate this process. However, while some of the proposed approaches achieve high performance, rapidly evolving Android malware has made them unable to maintain their accuracy over time. This has created a need in the community to conduct further research, and build more flexible ML pipelines. Doing so, however, is currently hindered by a lack of systematic overview of the existing literature, to learn from and improve upon the existing solutions. Existing survey papers often focus only on parts of the ML process (e.g., data collection or model deployment), while omitting other important stages, such as model evaluation and explanation. In this paper, we address this problem with a review of 42 highly-cited papers, spanning a decade of research (from 2011 to 2021). We introduce a novel procedural taxonomy of the published literature, covering how they have used ML algorithms, what features they have engineered, which dimensionality reduction techniques they have employed, what datasets they have employed for training, and what their evaluation and explanation strategies are. Drawing from this taxonomy, we also identify gaps in knowledge and provide ideas for improvement and future work.
Pre- and postoperative physiotherapy using a digital application decreases length of stay without reducing patient outcomes following total knee arthroplasty
Authors: Hardwick-Morris Max , Carlton Simon , Twiggs Joshua , Miles Brad , Liu David 
Published: August 2022

Abstract
Introduction
Total Knee Arthroplasty (TKA) for both patients and the surgical team is a journey spanning many months, rather than purely a hospital episode of care. To improve patient outcomes and reduce costs in TKA, greater emphasis should be placed on the pre- and postoperative periods as, historically, innovation has focused on the intraoperative execution of the surgery. The purpose of this study was to determine if a pre- and postoperative physiotherapy program delivered via a digital application could reduce hospital length of stay (LOS) without compromising patient outcomes.

Methods
A retrospective series of 294 patients who underwent TKA from a single-surgeon in a single-centre was examined. This included 232 patients who underwent a pre- and postoperative physiotherapist-led program delivered via a digital application and 62 patients who underwent a conventional pre- and postoperative protocol. 2:1 nearest neighbour propensity score matching was performed to establish covariate balance between the cohorts. Data collected included pre- and postoperative Knee Injury and Osteoarthritis Outcome Score (KOOS), KOOS for Joint Replacement (KOOS, JR), and acute, rehabilitation, and total LOS.

Results
No significant difference in KOOS or KOOS, JR scores was observed at 12-month follow-up. A significantly reduced rehabilitation (P = 0.014) and total LOS (P = 0.015) was observed in the patients who received the digital physiotherapy program.

Conclusions
There may be significant economic benefits to a pre- and postoperative physiotherapy program delivered via a digital application. Our results suggest that a digital physiotherapist-led patient program may reduce the need for inpatient rehabilitation services without compromising patient outcomes.