bluuebunny/crossref_metadata_2025_split huggingface dataset:
The histone deacetylase Cfhos2 is a key epigenetic factor regulating appressorium development and pathogenesis in apple Glomerella leaf spot fungus Colletotrichum fructicola
Authors: Cao Mengyu , Zhang Zhaohui , Tian Huanhuan , Yu Wei , Zhao Xuemei , Yang Wenrui , Zhang Rong , Sun Guangyu , Liang Xiaofei 
Published: October 2022

AbstractGlomerella leaf spot (GLS) is a devastating fungal disease that damages the leaves and fruits and reduces tree vigor of apple (Malus domestica). The pathogen infection mechanism, however, remains elusive. Histone-modifying enzymes, which regulate eukaryotic chromatin conformation and gene expression, are key epigenetic factors controlling fungal development, virulence, and secondary metabolism. To dissect the epigenetic regulation of GLS pathogenesis, we characterized a histone deacetylase gene Cfhos2 in Colletotrichum fructicola, the causing agent of GLS. Cfhos2 deletion mutants were mildly reduced in vegetative growth rate, but almost lost pathogenicity on apple leaves. Cfhos2 deletion mutants induced strong plant defense responses manifested by epidermal cell browning, granulation, and distortion of pathogen invasive hyphae. The mutants also showed defect in appressorial development on cellophane, but not on parafilm or on apple leaf surface, suggesting that the defect in appressorial development is surface-dependent. RNA-seq based transcriptome analysis highlighted that Cfhos2 regulates secondary metabolism-related virulence genes during infection. Moreover, the expression of an apple defense-related F-box protein was strongly induced by infection with Cfhos2 deletion mutants. Taken together, we demonstrate that Cfhos2 is a key epigenetic factor regulating appressorium development, virulence gene expression, and GLS pathogenesis in C. fructicola. The results provide important information for understanding the virulence mechanisms of C. fructicola.
Precise orbit determination for a large LEO constellation with inter-satellite links and the measurements from different ground networks: a simulation study
Authors: He Xingchi , Hugentobler Urs , Schlicht Anja , Nie Yufeng , Duan Bingbing 
Published: October 2022

AbstractGeodetic applications of Low Earth Orbit (LEO) satellites requires accurate satellite orbits. Instead of using onboard Global Navigation Satellite System observations, this contribution treats the LEO satellite constellation independently, using Inter-Satellite Links and the measurements of different ground networks. Due to geopolitical and geographical reasons, a ground station network cannot be well distributed. We compute the impact of different ground networks (i.e., global networks with different numbers of stations and regional networks in different areas and latitudes) on LEO satellite orbit determination with and without the inter-satellite links. The results are based on a simulated constellation of 90 LEO satellites. We find that the orbits determined using a high latitude network is worse than using a middle or low latitude network. This is because the high latitude network has a poorer geometry even if the availability of satellite measurements is higher than for the other two cases. Also, adding more stations in a regional network shows almost no improvements on the satellite orbits if the number of stations is more than 16. With the help of ISL observations, however, the satellite orbits determined with a small regional network can reach the same accuracy as that with the global network of 60 stations. Furthermore, satellite biases can be well estimated (less than 0.6 mm) and have nearly no impact on satellite orbits. It does thus not matter if they are not physically calibrated for estimating precise orbits.
Learning stochastic filtering
Authors: Ramakrishnan Rahul O. , Auconi Andrea , Friedrich Benjamin M. 
Published: October 2022

AbstractWe quantify the performance of approximations to stochastic filtering by the Kullback-Leibler divergence to the optimal Bayesian filter. Using a two-state Markov process that drives a Brownian measurement process as prototypical test case, we compare two stochastic filtering approximations: a static low-pass filter as baseline, and machine learning of Volterra expansions using nonlinear Vector Auto-Regression (nVAR). We highlight the crucial role of the chosen performance metric, and present two solutions to the specific challenge of predicting a likelihood bounded between 0 and 1.
Survivin: A Potential Marker of Resistance to Somatostatin Receptor Ligands
Authors: Herkenhoff Clarissa G Borba , Trarbach Ericka B , Batista Rafael Loch , Soares Iberê Cauduro , Frassetto Fernando Pereira , do Nascimento Felipe Barjud Pereira , Grande Isabella Pacetti Pajaro , Silva Paula P B , Duarte Felipe H G , Bronstein Marcello D , Jallad Raquel S 
Published: October 2022

AbstractContextInvasive and somatostatin receptor ligand (SRL)-resistant pituitary tumors represent a challenge in the clinical practice of endocrinologists. Efforts have been made to elucidate reliable makers for both. Survivin and eukaryotic translation initiation factor-binding protein 1 (4EBP1) are upregulated in several cancers and involved in apoptosis and cell proliferation.ObjectiveWe explored the role of these markers in somatotropinomas.MethodsImmunostains for survivin and 4EBP1, and also for somatostatin receptor type 2 (SSTR2), Ki-67, and cytokeratin 18, were analyzed in tissue microarrays containing 52 somatotropinoma samples. Tumor invasiveness was evaluated in all samples while drug resistance was evaluated in 34 patients who received SRL treatment. All these parameters were correlated with first-generation SRL (fg-SRL) responsiveness and tumor invasiveness.ResultsLow survivin expression (P = 0.04), hyperintense signal on T2 weighted image (T2WI) (P = 0.01), younger age (P = 0.01), sparsely granular adenomas (SGA) (P = 0.04), high postoperative growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels (P = 0.049 and P &lt; 0.001, respectively), and large postoperative tumor size (P = 0.02) were associated with resistance to fg-SRL. Low survivin and SSTR2 expression and high 4EBP1 expression were associated with SGA (P = 0.04, P = 0.01, and P = 0.001, respectively). Younger age (P = 0.03), large tumor pre- and postoperative (P = 0.04 and P = 0.006, respectively), low SSTR2 expression (P = 0.03), and high baseline GH and IGF-1 (P = 0.01 and P = 0.02, respectively) were associated with tumor invasiveness. However, survivin, 4EBP1, Ki-67, and granulation patterns were not associated with tumor invasion.ConclusionThis study suggests that low survivin expression is predictive of resistance to fg-SRL in somatotropinomas, but not of tumor invasiveness.
The CRL4 E3 ligase Mahjong/DCAF1 controls cell competition through the transcription factor Xrp1, independently of polarity genes
Authors: Kumar Amit , Baker Nicholas E. 
Published: October 2022

ABSTRACT
Cell competition, the elimination of cells surrounded by more fit neighbors, is proposed to suppress tumorigenesis. Mahjong (Mahj), a ubiquitin E3 ligase substrate receptor, has been thought to mediate competition of cells mutated for lethal giant larvae (lgl), a neoplastic tumor suppressor that defines apical-basal polarity of epithelial cells. Here, we show that Drosophila cells mutated for mahjong, but not for lgl [l(2)gl], are competed because they express the bZip-domain transcription factor Xrp1, already known to eliminate cells heterozygous for ribosomal protein gene mutations (Rp/+ cells). Xrp1 expression in mahj mutant cells results in activation of JNK signaling, autophagosome accumulation, eIF2α phosphorylation and lower translation, just as in Rp/+ cells. Cells mutated for damage DNA binding-protein 1 (ddb1; pic) or cullin 4 (cul4), which encode E3 ligase partners of Mahj, also display Xrp1-dependent phenotypes, as does knockdown of proteasome subunits. Our data suggest a new model of mahj-mediated cell competition that is independent of apical-basal polarity and couples Xrp1 to protein turnover.
Management of acute pancreatitis in the Emergency Department
Authors: Tsiampas Ioannis 
Published: October 2022

Background: Heterogeneity in clinical manifestations and outcome of pancreatitis constitutes an obstacle for the creation of a common treatment algorithm by the scientific community.
Aim: The aim of the present study was to systematically review the management of cases of acute pancreatitis in Emergency Department (ED) and her correlation with outcome.
Methods: Search the database Pubmed and were included observational studies and randomized trials in adults in English.
Results: The search yielded 13 studies. Of these, 3 concerned the diagnostic approach of the disease in ED and concluded that lipase is the most reliable test in diagnosis, while computed tomography of the abdomen is not recommended as a routine examination. 5 out of 13 studies analyzed the usefulness of disease severity classification systems, with the BISAP and HASP score appearing as reliable as the APACHE II and RANSON score, but having an advantage in rapid patient evaluation. The last 5, studied the need for immediate therapeutic / invasive method, with the time of surgery from the arrival at the ED being decisive as it affects the outcome of the disease. It is generally seen that the early invasive method is gaining ground in the treatment of the disease.
Conclusion: The main goal is to predict the most severe forms of the disease in order to receive the right (invasive or not) treatment to improve survival and quality of life.
ETHER - a partially forgotten anesthetic
Authors: Pożarowska Kinga , Rosińska Agata , Orczykowski Maciej , Tyszkiewicz Marcin , Choina Magdalena 
Published: October 2022

INTRODUCTION: Ether is the common name for diethylether (CH3-CH2-O-CH2-CH3). It is a colorless, volatile and highly flammable liquid with a characteristic pungent odor. It was widely used as an anesthetic in the past and is now a component of solvents.
PURPOSE OF THE WORK: The purpose of this paper is to introduce ether as a potentially forgotten substance in the world of Western medicine. Its history, current use, potential for abuse for narcotic purposes, addiction, and the benefits of anesthesia with this agent in impoverished countries.
DESCRIPTION OF THE STATE OF KNOWLEDGE: Ether was first synthesized in 1540 by Valerius Cordus. Ether is characterized by rapid absorption, rapid distribution in the central nervous system and rapid, short-lasting effects. Ether has high solubility in blood/gas, which slows both induction and recovery of anesthesia. In developing countries, it is suggested that ether be used as an intraoperative analgesia. But it should be remembered, despite the new psychoactive substances, other inexpensive and readily available intoxicants can be found, among them ether. It has been noted in numerous publications that abuse of ether is associated with abuse of other drugs and/or alcohol dependence.
SUMMARY: It is important to remember that ether compounds are widespread. People struggling with the urge to abuse substances can get these substances easily and cheaply. On the other hand, ether anesthesia is a great solution for developing countries. There are situations there that due to lack of funds, some operations are carried out without anesthesia. Ether is cheap, and administering anesthesia with it is quite simple, and could give wonderful relief to these patients.
An Invitation to Formal Power Series
Authors: Sambale Benjamin 
Published: October 2022

AbstractThis is an account on the theory of formal power series developed entirely without any analytic machinery. Combining ideas from various authors we are able to prove Newton’s binomial theorem, Jacobi’s triple product, the Rogers–Ramanujan identities and many other prominent results. We apply these methods to derive several combinatorial theorems including Ramanujan’s partition congruences, generating functions of Stirling numbers and Jacobi’s four-square theorem. We further discuss formal Laurent series and multivariate power series and end with a proof of MacMahon’s master theorem.
Ein Vorschlag für die datenschutzkonforme Gestaltung von Datenschutz-Grundsätzen und -Schutzmaßnahmen in IT-Systemen – Angemessene technische und organisatorische Schutzmaßnahmen nach Art. 32 DSGVO
Authors: Selzer Annika , Timm Ingo J. 
Published: October 2022

ZusammenfassungPlant eine Organisation ein neues IT-System, mit dem es personenbezogene Daten ihrer Kunden oder Mitarbeiter verarbeiten möchte, so stellt es den Planer des IT-Systems häufig vor große Herausforderungen, die Entwicklung und Inbetriebnahme des neuen IT-Systems unter Beachtung der einschlägigen datenschutzrechtlichen Anforderungen umzusetzen. Häufigster Hemmschuh für eine datenschutzkonforme Entwicklung und Inbetriebnahme eines neuen IT-Systems sind einerseits fehlende Fachkenntnisse zu datenschutzrechtlichen Rahmenbedingungen – insbesondere die datenschutzrechtlichen Anforderungen, die sich aus der Datenschutz-Grundverordnung ergeben und die entsprechend des darin verankerten risikobasierten Ansatzes angemessen umzusetzen sind – sowie andererseits fehlende Erfahrungen zur Gestaltung der Umsetzung dieser Anforderungen, auch hinsichtlich der Einbindung von Funktionsträgern innerhalb der Organisation seitens des Planers des IT-Systems. Der vorliegende Aufsatz möchte vor diesem Hintergrund einen Beitrag dazu leisten, Planern von IT-Systemen die wichtigsten einschlägigen Datenschutzanforderungen aufzuzeigen sowie Empfehlungen zur Umsetzung dieser Anforderungen zu geben.
Éxito académico de personas con discapacidad en el contexto universitario. Un modelo analítico cualitativo
Authors: Ramírez Morera Marcela , Díaz Jiménez Rosa María 
Published: October 2022

El artículo describe un modelo analítico cualitativo para conocer los factores de éxito académico de mujeres con discapacidad en los contextos universitarios[1], mediante el estudio comparado de dos casos (un hombre y una mujer con discapacidad) en la Universidad de Costa Rica. A través de 8 narraciones biográficas se analizan las dimensiones personales, familiares, grupos de pares y docentes, de las trayectorias educativas y sociales que configuraran su éxito académico.
ENZYMATIC ACTIVITY OF THE FUNGUS Pochonia chlamydosporia (SORDARIOMYCETES: HYPOCREALES) AND ITS OVICIDAL POTENTIAL ON EGGS OF Toxocara canis (NEMATODA: ASCARIDIDA)
Authors: Souza Castro Lorena , Vilhena Freire Martins Isabella , Menezes Tunholi Victor , Victor de Araújo Jackson , Roldi Vieira Fernanda de Paula 
Published: October 2022

Biological control is considered one of the most used alternative measures to combat helminths of relevance in veterinary medicine and public health. Among these parasites, Toxocara canis stands out for its high prevalence and worldwide distribution, in addition to being the main cause of visceral larva migrans in man. The present work aimed the fungus Pochonia chlamydosporia (isolate Pc-10) on eggs of T. canis. In order to do this, fertile nematode eggs were obtained by dissection of adult females fertilized specimens. After obtaining the eggs, they were inserted into 24 well plates previously À lled with different concentrations of enzymatic extract of the fungus (100, 200, 400 and 500 μL). In addition, the behavior of P. chlamydosporia hyphae on Toxocara canis eggs was also observed in 2% wateragar medium (2% WA+ fungal isolate) when compared to the control group (2% WA + water). It was veriÀ ed ovicidal activity with the enzymatic extract of P. chlamydosporia at concentrations of 400 and 500 μL. At the same time, after 12 days of exposure of the T. canis eggs to P. chlamydosporia mycelia it was possible to observe the fungus action on eggshells, including penetration of the hyphae and colonization of the egg inside. The results conÀ rm the ovicidal potential of the fungus and suggest its applicability in toxocariasis control programs.
Keywords: Pochonia chlamydosporia, Toxocara canis, Toxocariasis, Nematodes, Biological control.
Induced Abortion and Life Satisfaction in Germany: The Role of Selection Processes and Short-Term Effects
Authors: Huss Björn , Kaiser Florian 
Published: October 2022

AbstractUnintended pregnancies resulting in induced abortion are occasionally associated with poor psychological well-being. In the literature, this is attributed to either (1) the consequences of abortion, (2) the consequences of unintended pregnancy, or (3) specific selection processes. This longitudinal study addresses these explanations based on data from the German family panel “pairfam” (n = 3,604 women). It compares changes in life satisfaction among different groups of women: Those who had an abortion, those who had a live birth, and those who were not pregnant. A matching procedure ensures the comparability of the groups. The results show that women reported temporarily lower life satisfaction immediately after abortion than similar women following live birth or in absence of pregnancy, while no significant group differences were found in the long run. However, abortion is preceded by significantly lower pre-event life satisfaction than live birth or absence of pregnancy. Persistent poor well-being should therefore primarily be considered a selection criterion for abortions resulting from unintended pregnancies rather than as their consequence.
A modern nagyváros vizuális reprezentációi. Irodalom és fotóművészet kapcsolódásai
Authors: Kovács Krisztina 
Published: October 2022

A magyar nagyváros vizuális megközelítése az európai nagyváros dimnezióival kezdődik. A város a modern kultúra első nagyszabású, képek végtelen sorát inspiráló témája, az európai modernizmus kultuszhelye, a hely, ahol a dolgok történnek: a hely, ahova postakocsin vagy vonaton érkezünk. A várost bejáró flâneur, a sétáló, köztük a fotós olyan forgatókönyvíró és rendező szerepét veszi fel, aki más emberek életének töredékeit kedve szerint történetté alakítja. A szövegek és a képek helyszínei, az előterek, a passzázsok, az utcák a modern városépítészeti diskurzus tételei szerint csupán „üres terek”, hely akkor válik belőlük, ha a kulturális és regionális kontextusból adódó jelentést kapnak. Ezek a térségek a teatralitás tereiként kezdenek működni, az utca a város olyan nyilvános tartozéka lesz, ahol a különböző kulturális hátterekhez, hagyományokhoz tartozó csoportok összetalálkoznak. Az utca kínálta látványokat szemléző művészek karakterei között egyre inkább és egyre gyakrabban bukkan fel a modellt kereső művész figurája, aki a várost fáradhatatlanul járó költő, író, újságíró, a modernitást dokumentáló festő és szobrász mellett egyre inkább a fotós lesz.
Kép forrása: Fortepan/Budapest Főváros Levéltára. Levéltári jelzet: HU.BFL.XV.19.d.1.05.153
Felfedezés és elhelyezés. Tanulságok Dulovits Jenő fotóművész-feltaláló életművének feltárásakor
Authors: Fejér Zoltán György 
Published: October 2022

Dulovits Jenő (1903–1972) tanár, fotóművész, szakíró és feltaláló a magyar fotótechnika-történet egyik legfontosabb, világhírűnek mondható alkotója. 1936–1959 között megjelent magyar, német, francia, cseh, holland és orosz nyelvű könyveinek rokonszenves fotói és szöveges tartalma miatt a hazai és európai amatőr fényképészek ezrei követték képkészítéssel kapcsolatos útmutatásait. Ezek legnagyobbrészt a téma ellenfényes megvilágítására és a lágyított képi rajzra vonatkoztak.A találmányain és szabadalmain alapuló műszaki megoldások egy része, így például a lágyító előtétlencse (DUTO) és az általa megtervezett fényképezőgép (DUFLEX) nevét hordozta és ezek az egész világon ismertté tették őt.A szerző húszévnyi munkáját foglalta össze tanulmányában. 2001-től szisztematikus alapossággal megismerte és feltárta Dulovits Jenő életét. Ehhez a szekunder adatokon túl levéltári kutatásai során megszerzett primer adatokat is felhasznált. Egy rokon megtalálása után megkapta Dulovits megmaradt személyes dokumentumait és iratait. Így olyan mennyiségű hiteles adat állt rendelkezésére, amiből már megírhatta és 2003-ban meg is jelentethette az életrajzot. Könyvekben, újságcikkekben és több kiállításon is közzétette az összegyűjtött anyagot. Ezeket a dokumentumokat 2019-től napjainkig különböző hazai közgyűjteményeknek, könyvtáraknak és múzeumoknak több részletben adta át, így biztosítva azt, hogy azokhoz a későbbi nemzedékek is hozzáférhessenek.A közzétételt az is indokolja, hogy a leírt eljárás/módszer annak típusossága miatt máskor, máshol és más személlyel kapcsolatban is alkalmazható.
Kép forrása: A szerző felvétele.
Novel simple algorithm for frequency planning and optimization in cellular networks
Authors: Alyouzbaki Yasameen A. Ghani 
Published: October 2022

AbstractOne of the most expensive components of constructing a cellular network is frequency planning. The cost of building and maintaining a network will be reduced if a set of base stations can be established with minimal service and preparation. Planning and optimization are carried out to guarantee that the scarce frequency is used to its maximum capability. The goal of this paper is to provide an autonomous method for planning and optimizing frequency in cellular networks. The method substitutes the inefficient, inaccurate, and time-consuming manual method. The automatic technique makes work easier for radio frequency (RF) engineers and lowers operating costs. Also, this article provides an autonomous planning and optimization technique that reduces intra-system interference levels to acceptable levels within the key performance indicators (KPIs) set for any suitable cellular network.
Criando o indizível
Authors: Santos Elizabeth de Jesus , Bernardo Kátia Jane Chaves 
Published: October 2022

INTRODUÇÃO: A psicanálise e a literatura são formas privilegiadas de expressar manifestações provenientes do inconsciente, havendo entre elas uma grande proximidade. Este trabalho aborda a ligação entre psicanálise e literatura tomando como referência o conceito freudiano de sublimação. OBJETIVO: O objetivo dessa pesquisa foi verificar como a escrita ficcional pode ser uma possibilidade de sublimação. Para cumprir esse objetivo buscou-se discorrer sobre a escrita ficcional; apresentar o conceito de sublimação; apontar possibilidades e limites da sublimação; relacionar a escrita ficcional à sublimação. MÉTODO: Trata-se de uma pesquisa qualitativa de caráter exploratório. Foi realizada uma revisão de literatura tomando-se como referência os textos freudianos que tratam da temática da pesquisa. CONCLUSÃO: A partir da leitura é possível constatar que a escrita ficcional pode constituir-se em uma possibilidade de sublimação para o escritor, apesar de existirem limitações da escrita como tal.
Representación de la identidad del individuo en el diseño de identidad visual del producto
Authors: MARTÍN-FRANCÉS AGUSTÍN 
Published: October 2022

La extendida estrategia de ofrecer los productos de consumo masivo en grandes hipermercados, donde la interacción entre vendedor y comprador ha desaparecido, ha llevado a considerar el packaging como algo imprescindible para conectar con el consumidor. En este contexto, el producto debe destacar entre la competencia del lineal mediante su aspecto, tanto por su forma como por su gráfica. Precisa, por tanto, de una fuerte identidad para ser el elegido y acabar en el carrito. Su diseño gráfico no consistirá únicamente en dotar de un estilo atractivo a la información de su contenido. Deberá emplear elementos gráficos que doten de personalidad al producto, que comuniquen de una manera directa lo que tienen de especial. La identidad del producto no se resuelve con la marca del fabricante, sino que necesita más recursos gráficos, principalmente emocionales. En ocasiones se recurre a retratos de individuos que respaldan su identidad.
Palabras clave: Diseño, identidad, packaging, producto, marca.