bluuebunny/crossref_metadata_2025_split huggingface dataset:
A revision of Scutellera (Hemiptera: Heteroptera: Scutelleridae)
Authors: RÉDEI DÁVID , TSAI JING-FU 
Published: January 2022

The genus Scutellera Lamarck, 1801 (Hemiptera: Heteroptera: Scutelleridae: Scutellerinae: Scutellerini) is revised. Three species are recognized: Scutellera nepalensis (Westwood, 1837), with two subspecies, S. nepalensis nepalensis and S. nepalensis amethystina (Germar, 1839), stat. nov.; S. perplexa (Westwood, 1837); and S. spilogastra (Walker, 1867), comb. nov. (= S. brevirostris Breddin, 1909, syn. nov.). The included species are redescribed, illustrated, keyed, their bionomics and distribution are reviewed. Lectotypes are designated for Tectocoris nepalensis Westwood, 1837, Calliphara amethystina Germar, 1839, S. lanius Stål, 1854, and Callidea spilogastra Walker, 1867. Scutellera perplexa is recorded for the first time from Nepal, Vietnam and Laos. Scutellera holosericea Dohrn, 1863, is removed from Scutellera and transferred to Procilia Stål, [1865], resulting in a formal combination Procilia holosericea (Dohrn, 1863), comb. nov.; the species is potentially a junior subjective synonym of the Afrotropical P. morgani (White, 1839); its type locality, Java, is considered as erroneous.
Preliminary Assessment of MetOp-Based Temperature and Humidity Statistical Retrievals within the 3D-Var AROME-France Prediction System
Authors: Silveira Bruna Barbosa , Fourrié Nadia , Guidard Vincent , Chambon Philippe , Mahfouf Jean-François , Brousseau Pierre , Moll Patrick , August Thomas , Hultberg Tim 
Published: January 2022

Abstract
The main objective of the study is to evaluate the feasibility and benefits of assimilating satellite temperature and humidity soundings (aka Level 2 or L2 profiles), instead of radiances, from the EUMETSAT Advanced Retransmission Service (EARS) into the AROME-France data assimilation system. The satellite soundings are operational forecast-independent retrievals that used the infrared sounder IASI in synergy with its companion microwave instruments AMSU-A and MHS on board the MetOp platforms. In this assimilation study, L2 profiles are used as pseudoradiosondes, discarding vertical error correlations and the instrument vertical sensitivity in the observation operator due to the lack of available averaging kernels. Three assimilation experiments were performed, the baseline (including all satellite radiances except those from IASI, AMSU-A, and MHS sounders), the control (with observations from the baseline plus IASI, AMSU-A, and MHS radiances), and the L2 experiment (with observations from the baseline and L2 temperature and humidity profiles). The assimilation runs cover the periods of the winter 2017 and summer 2018. The forecast skills of the three experiments are gauged against independent analyses and observations. Despite that the vertical observation operator is not accounted for in this study, it is found that L2 profile assimilation does not have a negative impact on 1-h temperature and humidity forecasts, especially in the midtroposphere. Their impacts are comparable in magnitude to the radiance ones in the operational AROME framework, except in terms of temperature and wind fields during winter where the impact is more negative than positive. These findings encourage further investigations.
A mock circulation loop to evaluate differential hypoxemia during peripheral venoarterial extracorporeal membrane oxygenation
Authors: Rozencwajg Sacha , Wu Eric L , Heinsar Silver , Stevens Michael , Chinchilla Josh , Fraser John F , Pauls Jo P 
Published: January 2022

Introduction Peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO) creates a retrograde flow along the aorta competing with the left ventricle (LV) in the so-called ‘mixing zone’ (MZ). Detecting it is essential to understand which of the LV or the ECMO flow perfuses the upper body – particularly the brain and the coronary arteries – in case of differential hypoxemia (DH). Methods We described a mock circulation loop (MCL) that enabled experimental research on DH. We recreated the three clinical situations relevant to clinicians: where the brain is either totally perfused by the ECMO or the LV or both. In a second step, we used this model to investigate two scenarios to diagnose DH: (i) pulse pressure and (ii) thermodilution via injection of cold saline in the ECMO circuit. Results The presented MCL was able to reproduce the three relevant mixing zones within the aortic arch, thus allowing to study DH. Pulse pressure was unable to detect location of the MZ. However, the thermodilution method was able to detect whether the brain was totally perfused by the ECMO or not. Conclusion We validated an in-vitro differential hypoxemia model of cardiogenic shock supported by VA ECMO. This MCL could be used as an alternative to animal studies for research scenarios.
Optimised versus standard automated peritoneal dialysis regimens pilot study (OptiStAR): A randomised controlled crossover trial
Authors: Bergling Karin , de Arteaga Javier , Ledesma Fabián , Öberg Carl M 
Published: January 2022

Background: The continuous global rise of end-stage kidney disease creates a growing demand of economically beneficial home-based kidney replacement therapies such as peritoneal dialysis (PD). However, undesirable absorption and exposure of peritoneal tissues to glucose remain major limitations of PD. Methods: We compared a reference (standard) automated PD regimen 6 × 2 L 1.36% glucose (76 mmol/L) over 9 h with a novel, theoretically glucose sparing (optimised) prescription consisting of ‘ultrafiltration cycles’ with high glucose strength (126 mmol/L) and ‘clearance cycles’ with ultra-low, physiological glucose (5 mmol/L) for approximately 40% of the treatment time. Twenty-one prevalent PD patients underwent the optimised regimen (7 × 2 L 2.27% glucose + 5 × 2 L 0.1% glucose over 8 h) and the standard regimen in a crossover fashion. Six patients were excluded from data analysis. Results: Median glucose absorption was 43 g (IQR 41–54) and 44 g (40–55) for the standard and optimised intervention, respectively ( p = 1). Ultrafiltration volume, weekly Kt/V creatinine and urea were significantly improved during optimised interventions, while no difference in sodium removal was detected. Post hoc analysis showed significantly improved ultrafiltration efficiency (ml ultrafiltration per gram absorbed glucose) during optimised regimens. No adverse events were observed except one incidence of drain pain. Conclusion: Optimised treatments were feasible and well tolerated in this small pilot study. Despite no difference in absorbed glucose, results indicate possible improvements of ultrafiltration efficiency and small solute clearances by optimised regimens. Use of optimised prescriptions as glucose sparing strategy should be evaluated in larger study populations.
Evaluation of Chinese freight train bearing condition based on spatiotemporal feature extraction
Authors: Si Jin , Shi Hongmei , Yang Jinsong 
Published: January 2022

Bearing failure in freight trains can directly affect operational safety. Therefore, bearing condition evaluation is of practical and critical significance. In this paper, a new method of evaluating the condition of the bearings is proposed based on spatiotemporal feature extraction with bearing temperature data. First, the temperature time series is divided into many sub-sequences with a sliding time window. Second, based on the forms of series anomaly, point anomaly, and pattern anomaly in time series, the spatiotemporal features extraction framework is presented, which combines manual feature extraction with machine learning methods. Specifically, series classification, distribution-based and increment-based outlier detection, model-based time series anomaly detection methods are utilized to extract abnormal features in temporal, spatial, and spatiotemporal dimensions. Third, a penalty vector is constructed by an ergodic accumulation of penalty values for the outliers. And the weights to each element in the penalty vector are allocated using correlation analysis. The penalty vector and the weights are then employed to calculate the bearing health indicator, which can quantify the health condition and determine the severity of the potential fault. Finally, the validity of the proposed evaluation method is verified with on-site historical temperature data of 15,120 bearings on 35 trains, which demonstrates an accuracy of more than 94%. The method can provide early warning for an average of 161 h before hotbox alarms. The results indicate the proposed method can effectively evaluate the bearing condition and provide supportive information for condition-based maintenance.
Low-frequency electroacupuncture improves disordered hepatic energy metabolism in insulin-resistant Zucker diabetic fatty rats via the AMPK/mTORC1/p70S6K signaling pathway
Authors: Liu Xiao-xiao , Zhang Li-zhi , Zhang Hai-hua , Lai Lan-feng , Wang Yi-qiao , Sun Jian , Xu Neng-gui , Li Zhi-xing 
Published: January 2022

Background and aim: Disordered hepatic energy metabolism is found in obese rats with insulin resistance (IR). There are insufficient experimental studies of electroacupuncture (EA) for IR and type 2 diabetes mellitus (T2DM). The aim of this study was to probe the effect of EA on disordered hepatic energy metabolism and the adenosine monophosphate (AMP)-activated protein kinase (AMPK)/mammalian target of rapamycin complex 1 (mTORC1)/ribosomal protein S6 kinase, 70-kDa (p70S6K) signaling pathway. Methods: Zucker Diabetic Fatty (ZDF) rats were randomly divided into three groups: EA group receiving EA treatment; Pi group receiving pioglitazone gavage; and ZF group remaining untreated (n = 8 per group). Inbred non-insulin-resistant Zucker lean rats formed an (untreated) healthy control group (ZL, n = 8). Fasting plasma glucose (FPG), fasting insulin (FINS), C-peptide, C-reactive protein (CRP) and homeostatic model assessment of insulin resistance (HOMA-IR) indices were measured. Hematoxylin–eosin (H&E) staining was used to investigate the liver morphologically. The mitochondrial structure of hepatocytes was observed by transmission electron microscopy (TEM). Western blotting was adopted to determine protein expression of insulin receptor substrate 1 (IRS-1), mTOR, mTORC1, AMPK, tuberous sclerosis 2 (TSC2) and p70S6K, and their phosphorylation. RT-PCR was used to quantify IRS-1, mTOR, mTORC1, AMPK and p70S6K mRNA levels. Results: Compared with the ZF group, FPG, FINS, C-peptide, CRP and HOMA-IR levels were significantly reduced in the EA group ( p < 0.05, p < 0.01). Evaluation of histopathology showed improvement in liver appearances following EA. Phosphorylation levels of AMPK, mTOR and TSC2 decreased, and IRS-1 and p70S6K increased, in hepatocytes of the ZF group, while these negative effects appeared to be alleviated by EA. Conclusions: EA can effectively ameliorate IR and regulate energy metabolism in the ZDF rat model. AMPK/mTORC1/p70S6K and related molecules may represent a potential mechanism of action underlying these effects.
Implementation of a centralized HPV-based cervical cancer screening programme in Tuscany: First round results and comparison with the foregoing Pap-based screening programme
Authors: Carozzi Francesca , Burroni Elena , Confortini Massimo , Pompeo Giampaolo , Bisanzi Simonetta , Cellai Filippo , Paganini Irene , Mantellini Paola , Iossa Anna , Lelli Lisa , Di Pierro Carmelina , Matucci Marzia , Cannistrà Stefania , Rosati Roberta , Mongia Alessandra , Visioli Carmen Beatriz , Gorini Giuseppe , Sani Cristina , the Tuscany HPV-based Screening Working Group  
Published: January 2022

Objective To evaluate performance of the first round of HPV-based screening in Tuscany region and compare it with the prior round of Pap-based screening Setting Tuscany region of Italy, where HPV-based cervical cancer screening started in 2013, with a strong level of centralization screening tests at the Regional Laboratory for Cancer Prevention (ISPRO). Methods The transition from Pap- to HPV-based screening was initiated for older women and at 3 out of 12 Tuscany Local Health Units (LHUs). Data from the Florence and Grosseto LHUs (about 300,000 women) were analysed and performance screening indicators estimated. Results HPV-based indicators recorded good performance, with increased compliance vs. the Pap-based programme. We registered a substantial decrease in waiting times from sampling to test reporting, probably related to the centralization strategy. Since the screening protocol was the same and conducted at a single laboratory, we could hypothesize that the difference in HPV positivity (6.8% in Florence vs. 8.4% in Grosseto) was due to a real difference in HPV prevalence among women of the two LHUs. The transition to HPV-based screening led to a significant increase both in colposcopy referral rate (4.3% vs. 1.2%) and CIN2+ detection rate (8.3‰ vs. 3.4‰). Conclusions HPV-based is more effective in detecting high-grade precancerous and cancerous lesions than Pap-based screening and is characterized by an “anticipatory effect” in the detection of CIN2+ lesions. The transition from Pap-based to HPV-based screening programme should include increased resources dedicated to colposcopy services. Centralization in a laboratory with long experience in this field promotes efficiency of the screening process.
Does Minimum Support Price Have Long-Run Associations and Short-Run Interplays with Yield Rates and Quantities of Outputs? A Study on Food and Non-food Grains in India
Authors: Das Ramesh Chandra 
Published: January 2022

Indian agricultural practices in most instances are nature dependent; notwithstanding, it contributes a huge amount to the nation’s gross domestic product and in providing food security to the masses. The government’s announcements of minimum support prices (MSPs) for the crops work as insurance for the farmers from distress sales in the times of bumper crops as well as from nature’s shocks. In the recent past, a new agricultural bill has been passed by both houses of the Indian Parliament which constitutes a major source of concern on the MSP. Under this backdrop, the present study investigates through an endogenous growth model incorporating MSP as the public policy variable and empirical analysis whether MSP has long-run relations with yield rates and total quantity of production of different food and non-food crops for 1983–2019. Using a unit root test, cointegration test and causality test under structural break, it concludes that MSP and yield rates, and MSP and outputs of the selected crops have long-run relations under different break points with temporary deviations from the equilibrium path. Further, there are certain crops like pulses and groundnuts where MSP makes a cause to yield rates and, on the other hand, there are the crops like jute and cotton where MSP makes a cause to quantity of production. Thus, it is recommended that the Government of India should revisit the new agricultural bill and make necessary amendments for the overall benefits of the farmers and the economy as a whole. JEL Classification: Q180; O4; C22
Models for Predicting Early Death in Patients With Stage IV Esophageal Cancer: A Surveillance, Epidemiology, and End Results–Based Cohort Study
Authors: Shi Min , Zhai Guo-qing 
Published: January 2022

Background Despite enormous progress in the stage IV esophageal cancer (EC) treatment, some patients experience early death after diagnosis. This study aimed to identify the early death risk factors and construct models for predicting early death in stage IV EC patients. Methods Stage IV EC patients diagnosed between 2010 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were selected. Early death was defined as death within 3 months of diagnosis, with or without therapy. Early death risk factors were identified using logistic regression analyses and further used to construct predictive models. The concordance index (C-index), calibration curves, and decision curve analyses (DCA) were used to assess model performance. Results Out of 4411 patients enrolled, 1779 died within 3 months. Histologic grade, therapy, the status of the bone, liver, brain and lung metastasis, marriage, and insurance were independent factors for early death in stage IV EC patients. Histologic grade and the status of the bone and liver metastases were independent factors for early death in both chemoradiotherapy and untreated groups. Based on these variables, predictive models were constructed. The C-index was .613 (95% confidence interval (CI), [.573–.653]) and .635 (95% CI, [.596–.674]) in the chemoradiotherapy and untreated groups, respectively, while calibration curves and DCA showed moderate performance. Conclusions More than 40% of stage IV EC patients suffered from an early death. The models could help clinicians discriminate between low and high risks of early death and strategize individually-tailed therapeutic interventions in stage IV EC patients.
Structural parameter inversion of a gravity dam based on the dynamic response induced by an underwater explosion
Authors: Liu Yijia , Wenbo Lu , Wang Gaohui , Linmei Lyu , Chen Yeqing 
Published: January 2022

The overall mechanical behavior of the structure of a gravity dam is comprehensively reflected by modal information included in the measured vibration response. In this study, the dynamic elastic modulus of the dam body and foundation materials were inverted via an underwater explosion, and analyzed. First, the first three main frequencies and basic mode shapes of the dam were obtained based on the acceleration response induced by the explosion. Then, the support vector regression model optimized with the particle swarm optimization algorithm was used to invert the mechanical parameters. The results indicate that the objective function that considers dominant frequency and mode shape has a greater advantage in terms of anti-noise compared to when only the dominant frequency is considered. The inverted dynamic elastic modulus is about 1.5 times that of the static elastic modulus of the corresponding material, and the calculated modal values using the inversion parameters are basically consistent with the measured values. This method provides a new way of determining the dynamic parameters of gravity dams.
Osimertinib induced cardiac failure and QT-prolongation in a patient with advanced pulmonary adenocarcinoma
Authors: Bardaro Floriana , Stirpe Emanuele 
Published: January 2022

Introduction Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR) used for the treatment of non-small cell lung cancer (NSCLC) presenting an EGFR mutation. Although Osimertinib has a better safety profile compared to older EGFR-TKIs and although adverse events (AEs) are described in literature, recently the relationship between Osimertinib therapy and cardiotoxicity is gaining attention. Case report A 79-years old woman, with a history of lung adenocarcinoma on treatment with Osimertinib since 2019, was recovered in our department because of acute respiratory failure and acute heart failure with QT prolongation. The patient's history included hypertension, type 2 diabetes, breast carcinoma, Tuberculosis. Management and outcome The patient discontinued Osimertinib therapy and we treated her with diuretics, ß-blocker, and oxygen. After an initial improvement, the heart failure worsened further, and the therapy had to be increased. We ruled out other respiratory causes of heart failure and cardiological causes of QT prolongation. After stable clinical improvement, the patient underwent coronary artery disease which was negative. Therefore, the most likely cause of acute heart disease was Osimertinib therapy. Discussion This is a rare case of concomitant QT prolongation and congestive heart failure induced by Osimertinib therapy. The cause of cardiotoxicity probably depends on factors related to the action of the drug and patient specific factors. The cardiotoxic risk in these patients seems underestimated and cardiotoxicity induced by new anticancer treatments is increasing in importance. Cardiac monitoring is recommended in neoplastic patients receiving Osimertinib therapy with cardiological risk factors.
Panitumumab Associated Acute Pancreatitis
Authors: Arbag Huseyin Can , Sumbul Hilmi Erdem , Buyuksimsek Mahmut , Ogul Ali , Yetisir Abdullah Evren , Koseci Tolga , Bozkurt Duman Berna , Tohumcuoglu Mert , Kesen Oguzhan , Cil Timucin 
Published: January 2022

Introduction The addition of panitumumab to chemotherapy in wild-type metastatic colon cancer contributes to survival. While the skin related side effects of panitumumab are well known, we wanted to present a case where it was a possible cause of acute pancreatitis. Case Report The FOLFOX regimen was started in a 67-year-old patient with sigmoid colon cancer and multiple liver metastases. After 2 cycles, genetic tests were concluded and panitumumab 6 mg/kg was added to the treatment. The patient who presented with abdominal pain 2 days after the treatment was hospitalized with acute pancreaatitis. Management & Outcome Abdominal tomography of the patient was compatible with acute pancreatitis. Oral intake was stopped, IV hydration was started. The patient, whose complaints regressed, was discharged on the 3rd day of hospitalization. Discussion Skin side effects related to panitumumab are observed quite frequently. Although panitumumab related gastrointestinal side effects have been reported, there is no data on acute pancreatitis. Panitumumab was added to the chemotherapy regimen he received, and it was thought that panitumumab might be the etiological factor in the case who developed pancreatitis.
Pro-BNP in the differential diagnosis of dyspnea in patients treated with immune-checkpoint inhibitors: Case Report
Authors: Baranseh Jalal , Ouryvaev Anton , Moady Gassan , Shai Ayelet 
Published: January 2022

Introduction Immune checkpoint inhibitors (ICI) induced cardiac toxicity can present with non-specific symptoms and signs. Early recognition and treatment are important; however, diagnosis can be challenging. Case report We describe a 67-year-old woman with a history of ICI induced pneumonitis who presented with dyspnea, hypoxemia and pulmonary infiltrates while treated with pembrolizumab for lung cancer, initially diagnoses with relapssed pneumonitis. When her condition did not improve with steroids, NT-pro-BNP level was tested and was markedly high, prompting additional tests for heart failure. Management and outcome The patient was diagnosed with ICI induced left ventricular dysfunction and treated with steroids, beta blockers, diuretics, and ACE inhibitors. Her symptoms and imaging studies markedly improved. Discussion Here, we review the literature on ICI induced cardiac toxicity and the role of NT-pro -BNP in triage of patients presenting with dyspnea in the emergency setting. We suggest that measurement of NT-pro -BNP be utilized in patients receiving ICI's and presenting with respiratory abnormalities, to rapidly assess for possible cardiac toxicity.