bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silicon Contamination During Alloy Oxidation in Water Vapour at 650 °C
Authors: Nguyen Thuan Dinh , Zhang Jianqiang , Young David J. 
Published: March 2022

AbstractA model Si-free alloy, Fe-30Cr (wt.%), was exposed to Ar-10H2O mixture (in vol.%) at 650 °C, forming a protective Cr2O3 scale, which contained silica. Liquid water used to form water vapour in a bubbler was either deionised or distilled. In both cases, low-level water impurities of Si, F, Cl, S, and Ca matched those detected in the Cr2O3 scales by TEM/EDX and ToF–SIMS. Consideration of water droplet and residual solute particle sizes, together with Stokes’ Law shows that entrainment of Si in the gas stream is likely. Calculation of mass transfer rates from the gas to the growing chromia scale show that the amount of silica in the scale is accounted for. Many laboratory experiments could be affected in this way.
Live synthesis
Authors: Finkbeiner Bernd , Klein Felix , Metzger Niklas 
Published: March 2022

AbstractSynthesis automatically constructs an implementation that satisfies a given logical specification. In this paper, we study the live synthesis problem, where the synthesized implementation replaces an already running system. In addition to satisfying its own specification, the synthesized implementation must guarantee a sound transition from the previous implementation. This version of the synthesis problem is highly relevant in “always-on” applications, where updates happen while the system is running. To specify the correct handover between the old and new implementation, we introduce an extension of linear-time temporal logic (LTL) called LiveLTL. A LiveLTL specification defines separate requirements on the two implementations and ensures that the new implementation satisfies, in addition to its own requirements, any obligations left unfinished by the old implementation. For specifications in LiveLTL, we show that the live synthesis problem can be solved within the same complexity bound as standard reactive synthesis, i.e., in 2EXPTIME. Our experiments show the necessity of live synthesis for LiveLTL specifications created from benchmarks of SYNTCOMP and robot control.
Medical physics services in radiology and nuclear medicine in Africa: challenges and opportunities identified through workforce and infrastructure surveys
Authors: Trauernicht Christoph , Hasford Francis , Khelassi-Toutaoui Nadia , Bentouhami Imen , Knoll Peter , Tsapaki Virginia 
Published: March 2022

AbstractThe International Atomic Energy Agency (IAEA) developed a staffing model to estimate the number of clinically qualified medical physicists (CQMP) that are required in an imaging facility, including diagnostic radiology and nuclear medicine. For the first time this staffing model was applied on a large scale across Africa. Within the framework of the IAEA African Regional Agreement (AFRA) Technical Cooperation (TC) project RAF6/053 entitled “Enhancing Capacity Building of Medical Physics to Improve Safety and Effectiveness of Medical Imaging (AFRA)”, a survey based on the IAEA staffing model was used to investigate the current CQMP workforce needs in imaging and radionuclide therapy in Africa in order to establish a baseline, identify gaps and suggest steps for improvement. The survey was open for five months, after which data verification was performed. 82 responses were received from 21 countries, including data from 97 diagnostic radiology and 40 nuclear medicine departments, as well as 75 interventional radiology departments and/or catheterization laboratories. Only 26·8% of centres employed an adequate number of CQMPs. The staffing model indicated that 134·3 CQMPs were required for these centres, but only 63 are currently employed in medical imaging and/or nuclear medicine at these centres. At least 11 countries do not have a single institution with an adequate number of CQMPs. Data analysis indicated that the number of radiology and nuclear medicine CQMPs is largely inadequate, at least by a factor of 20 in almost all countries in the region.
PDC bit optimization scheme for tight oil reservoirs in the Jidong Oilfield based on rock anti-drilling characteristics
Authors: Xiaofeng Xu , Wei Song , Kuanliang Zhu , Changhao Wang , Yan Zhou , Yunfeng Li , Shibin Li 
Published: March 2022

AbstractThe tight oil reservoir rocks in the Jidong Oilfield are generally characterized by high hardness, strong abrasiveness, and extremely unevenness, which seriously reduce the drilling efficiency. In view of this problem, the mineral composition, hardness, plasticity coefficient, and drillability of rocks were first determined. It was found that the rock integrity, compactness and high hardness are the main factors leading to the low rock breaking efficiency of PDC bits. Then, combined with logging data, the drilling resistance profile of the whole well section was established. According to the crushing mechanism of rocks under the action of a PDC bit, the mechanical model of a single composite plate under rock crushing conditions is established, and the influence of the back angle on the cutting force is analyzed. The flow field distribution of the drill bit surface under different nozzle combinations was calculated by finite element numerical simulation. Based on the experimental and simulation results, the optimal backward angle was 15°, and the optimal nozzle combination was two 16-mm central nozzles and five 14-mm peripheral nozzles. Finally, a personalized PDC bit design scheme for tight oil reservoirs in the Jidong Oilfield was proposed. The scheme includes the following: (1) a 5-blade straight-arc crown is profiled; (2) anti-impact cylindrical components are set; (3) the nozzle hydraulic structure adopts a bending type; and (4) the diameter-retaining teeth and diversion grooves are optimized. The optimized bit reduces stick–slip, improves stability, and has an obvious acceleration effect.
Meeting multiplicative thinking through thought-provoking tasks
Authors: Cheeseman Jill , Downton Ann , Ferguson Sarah , Roche Anne 
Published: March 2022

AbstractChildren’s multiplicative thinking as the recognition of equal group structures and the enumeration of the composite units was the subject of this research. In this paper, we provide an overview of the Multiplication and Division Investigations project. The results were obtained from a small sample of Australian children (n = 21) in their first year of school (mean age 5 years 6 months) who participated in a teaching experiment of five lessons taught by their classroom teacher. The tasks introduced children to the “equal groups” aspect of multiplication. A theoretical framework of constructivist learning, together with research literature underpinning early multiplicative thinking, tasks, and children’s thinking, was used to design the research. Our findings indicate that young children could imagine equal group structures and, in doing so, recognise and enumerate composite units. As the children came to these tasks without any prior formal instruction, it seemed that they had intuitive understandings of equal group structures based on their life experiences. We argue that the implications for teaching include creating learning provocations that elicit children’s early ideas of multiplication, visualisation, and abstraction. The research has also shown the importance of observing children, listening to their explanations of their thinking, and using insights provided by their drawings.
A novel strategy for high-throughput sample collection, analysis and visualization of explosives’ concentrations for contaminated areas
Authors: Kober S. L. , Schaefer P. , Hollert H. , Frohme M. 
Published: March 2022

AbstractThe use of explosives has led to a widespread distribution of 2,4,6-trinitrotoluene (TNT) and its by- and degradation products in the soil on former production and testing sites. The investigation of those large contaminated sites is so far based on a few selected soil samples, due to high costs of conventional HPLC and GC analysis, although huge differences in concentrations can already be found in small areas and different collection depths. We introduce a novel high-throughput screening system for those areas, which combines a smartphone-based collection of GPS data and soil characteristics with a fast MALDI-TOF MS quantification of explosives in soil sample extracts and finally a heatmap visualization of the explosives’ spread in soil and an analysis of correlation between concentrations and soil characteristics. The analysis of a 400 m2 area presented an extensive contamination with TNT and lower concentrations of the degradation and by-products aminodinitrotoluenes (ADNT) and dinitrotoluenes (DNT) next to a former production facility for TNT. The contamination decreased in deeper soil levels and depended on the soil type. Pure humus samples showed significantly lower contaminations compared to sand and humus/sand mixtures, which is likely to be caused by an increased binding potential of the humic material. No correlation was found between the vegetation and the concentration of explosives. Since the results were obtained and visualized within several hours, the MALDI-TOF MS based comprehensive screening and heatmap analysis might be valuable for a fast and high-throughput characterization of contaminated areas.
Retailer’s Dual Role in Digital Marketplaces
Authors: Wulfert Tobias , Schütte Reinhard 
Published: March 2022

AbstractDigital marketplaces have entered the retail sector and have proven to be a successful business model compared to traditional retailing. Established retailers are increasingly launching digital marketplaces as well as participating in marketplaces of pure online companies. Retailers transforming to digital marketplaces orchestrate formerly independent markets and enable retail transactions between participants while simultaneously selling articles from their own assortment to customers in the digital marketplace (dual role). A retailer’s dual role must be supported by retail information systems. However, this support is not explicitly represented in existing reference architectures for retail information systems. Thus, we propose to develop a reference architecture for retail information systems that facilitates the orchestration of supply- and demand-side participants, selling their own articles, and providing innovation platform services. We apply a design science research approach and present nine architectural requirements that a reference architecture for a multi-sided market business model in retail needs to fulfill (dual role, additional participants, affiliation, matchmaking, variety of services, innovation services, smart services, aggregated assortment, and boundary resources) from the rigor cycle. From the first design iteration, we propose four exemplary, conceptual architectural patterns as a solution for the requirements (matchmaking for participants, innovation platform services, boundary resources, and aggregated assortment). These patterns can form a conceptual reference architecture that guides the design and implementation of information systems.
Short-Term Efficacy and Safety of Non-Ablative Laser Treatment Alone or with Estriol or Moisturizers in Postmenopausal Women with Vulvovaginal Atrophy
Authors: Alvisi Stefania , Lami Alessandra , Baldassarre Maurizio , Lenzi Jacopo , Mancini Ilaria , Seracchioli Renato , Meriggiola Maria Cristina 
Published: March 2022

ABSTRACTBackgroundAmong treatments for vulvo-vaginal atrophy (VVA), there is a new kind of energy-based device, the non-ablative CO2 laser.AimThis study aimed to assess the efficacy and safety of the non-ablative CO2 laser in menopausal women with VVA as a monotherapy or in association with vaginal estriol or moisturizer.MethodsSeventy-five women with VVA received laser treatment (Laser group), laser plus estriol gel (Laser+E) or laser plus moisturizers (Laser+M). The study protocol consisted of 3 monthly laser sessions (t0, t1, t2) and a gynecological examination at baseline and 1 month after last laser treatment (t3). Objective measures included VHI (Vaginal Health Index) and VuHI (Vulvar Health Index); subjective symptoms of VVA (Dryness, Burning, Itching, Dysuria) evaluated via visual analog scales, sexual function evaluated by FSFI (Female Sexual Function Index), FSDS (Female Sexual Distress Score) and MENQOL (Mopause-specific Quality Of Life). Adverse events and discomfort encountered during the procedure were also assessed.OutcomesPrimary outcomes were the evaluation of VHI and VuHI and secondary outcomes were changes in VVA symptoms (VAS), sexual function (MENQOL, FSFI, FSDS) and discomfort during the procedure.ResultsSeventy-five women (25 in Laser, 25 in Laser+E and 25 in Laser+M group) completed the study. At t3, mean VHI, VuHI, dryness, burning and itching VAS scores improved significantly with no differences between the groups. The lubrication domain of FSFI improved significantly only in the Laser+M group, while the pain domain improved significantly in all women with no differences between the groups. FSFI and FSDS overall scores and MENQOL sexual domain improved in all women with no significant difference between the groups. The mean score of the pain during the procedure was low at t0 and did not change throughout the study.Clinical implicationsThis study extends knowledge concerning the effectiveness of a new non-ablative CO2 laser in post-menopausal women with VVA.Strengths & limitationsThis is one of the first studies on this kind of laser and is the first to compare the effectiveness of laser treatment alone or in combination with vaginal estriol or moisturizers. Parameters of VVA and sexual function were evaluated using validated tools. Study limitations include short follow-up time, the limited number of participants and the absence of a sham-controlled group.ConclusionNon-ablative CO2 laser seems to be an effective treatment for VVA in menopausal women. Our preliminary data shows that it can be effective as monotherapy or with adjuvant treatments.
Current Concepts of Mixed Pathologies in Neurodegenerative Diseases
Authors: Forrest Shelley L. , Kovacs Gabor G. 
Published: March 2022

ABSTRACT:Neurodegenerative diseases are a pathologically, clinically and genetically diverse group of disorders without effective disease-modifying therapies. Pathologically, these disorders are characterised by disease-specific protein aggregates in neurons and/or glia and referred to as proteinopathies. Many neurodegenerative diseases show pathological overlap with the same abnormally deposited protein occurring in anatomically distinct regions, which give rise to specific patterns of cognitive and motor clinical phenotypes. Sequential distribution patterns of protein inclusions throughout the brain have been described. Rather than occurring in isolation, it is increasingly recognised that combinations of one or more proteinopathies with or without cerebrovascular disease frequently occur in individuals with neurodegenerative diseases. In addition, complex constellations of ageing-related and incidental pathologies associated with tau, TDP-43, Aβ, α-synuclein deposition have been commonly reported in longitudinal ageing studies. This review provides an overview of current classification of neurodegenerative and age-related pathologies and presents the spectrum and complexity of mixed pathologies in community-based, longitudinal ageing studies, in major proteinopathies, and genetic conditions. Mixed pathologies are commonly reported in individuals >65 years with and without cognitive impairment; however, they are increasingly recognised in younger individuals (<65 years). Mixed pathologies are thought to lower the threshold for developing cognitive impairment and dementia. Hereditary neurodegenerative diseases also show a diverse range of mixed pathologies beyond the proteinopathy primarily linked to the genetic abnormality. Cases with mixed pathologies might show a different clinical course, which has prognostic relevance and obvious implications for biomarker and therapy development, and stratifying patients for clinical trials.
Phonetic and Phonological Salience in Tone Processing
Authors: Barzilai Maya L. 
Published: March 2022

AbstractThe aim of this study is to determine whether it is the phonetic or phonological effect on processing that is stronger when the two effects are in conflict. Results are presented from a recall experiment, in which speakers of French and Tłı̨chǫ (Dene, Canada) recall syllables with either H or L tone. While French speakers remembered H syllables more accurately, Tłı̨chǫ speakers remembered L tones more accurately. The findings show simultaneous effects of phonetics and phonology, and have implications for notions of salience and how it can be measured as well as for the different types of salience that are active in speech sound processing.
COVID-19 as a Metaphor: Understanding COVID-19 Through Social Media Users
Authors: Colak Figen Unal 
Published: March 2022

Abstract

Objective:
This study, which aims to reveal the metaphorical perceptions of social media users regarding the term, COVID-19, is in accordance with the phenomenological method.

Method:
The phenomenological method was used in this study. In July 2020, a total of 125 social media users voluntarily participated in this research study and were asked to derive metaphors regarding the concept of COVID-19.

Results:
With the participation of social media users, metaphors about COVID-19 were determined. These metaphors, which were provided completely voluntarily in response to social media posts, reveals that the participants approached the COVID-19 phenomenon with a variety of meanings.

Conclusions:
When the metaphors derived by the participants are examined through different categories, it can be seen that a variety of metaphors are produced and almost all of them attribute negative meanings to COVID-19. A significant part of the metaphors evoke disasters and unexpected events. The absence of more hopeful metaphors regarding the end of the pandemic, may stem from the fact that this study took place during the middle of the pandemic, when discussions of the “new normal” were being made just after the first wave.
Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair
Authors: Nikitaki Zacharenia , Velalopoulou Anastasia , Zanni Vassiliki , Tremi Ioanna , Havaki Sophia , Kokkoris Michael , Gorgoulis Vassilis G. , Koumenis Constantinos , Georgakilas Alexandros G. 
Published: March 2022

Abstract
DNA damage and repair studies are at the core of the radiation biology field and represent also the fundamental principles informing radiation therapy (RT). DNA damage levels are a function of radiation dose, whereas the type of damage and biological effects such as DNA damage complexity, depend on radiation quality that is linear energy transfer (LET). Both levels and types of DNA damage determine cell fate, which can include necrosis, apoptosis, senescence or autophagy. Herein, we present an overview of current RT modalities in the light of DNA damage and repair with emphasis on medium to high-LET radiation. Proton radiation is discussed along with its new adaptation of FLASH RT. RT based on α-particles includes brachytherapy and nuclear-RT, that is proton-boron capture therapy (PBCT) and boron-neutron capture therapy (BNCT). We also discuss carbon ion therapy along with combinatorial immune-based therapies and high-LET RT. For each RT modality, we summarise relevant DNA damage studies. Finally, we provide an update of the role of DNA repair in high-LET RT and we explore the biological responses triggered by differential LET and dose.
Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)
Authors: Monti Hughes Andrea 
Published: March 2022

Abstract
Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on the administration of boron carriers incorporated preferentially by tumour cells, followed by irradiation with a thermal or epithermal neutron beam. BNCT clinical results to date show therapeutic efficacy, associated with an improvement in patient quality of life and prolonged survival. Translational research in adequate experimental models is necessary to optimise BNCT for different pathologies. This review recapitulates some examples of BNCT radiobiological studies for different pathologies and clinical scenarios, strategies to optimise boron targeting, enhance BNCT therapeutic effect and minimise radiotoxicity. It also describes the radiobiological mechanisms induced by BNCT, and the importance of the detection of biomarkers to monitor and predict the therapeutic efficacy and toxicity of BNCT alone or combined with other strategies. Besides, there is a brief comment on the introduction of accelerator-based neutron sources in BNCT. These sources would expand the clinical BNCT services to more patients, and would help to make BNCT a standard treatment modality for various types of cancer. Radiobiological BNCT studies have been of utmost importance to make progress in BNCT, being essential to design novel, safe and effective clinical BNCT protocols.
Hydrodynamics of an inertial squirmer and squirmer dumbbell in a tube
Authors: Ouyang Zhenyu , Lin Zhaowu , Yu Zhaosheng , Lin Jianzhong , Phan-Thien Nhan 
Published: March 2022

We study the hydrodynamics of a spherical and dumbbell-shaped microswimmer in a tube. Combined with a squirmer model generating tangential surface waves for self-propulsion, a direct-forcing fictitious domain method is employed to simulate the swimming of the microswimmers. We perform the simulations by considering the variations of the swimming Reynolds numbers (Re), the blockage ratios (κ) and the relative distances (ds) between the squirmers of the dumbbell. The results show that the squirmer dumbbell weakens the inertia effects of the fluid more than an individual squirmer. The constrained tube can speed up an inertial pusher (propelled from the rear) and an inertia pusher dumbbell; a greater distance ds results in a slower speed of an inertial pusher dumbbell but a faster speed of an inertial puller (propelled from the front) dumbbell. We also illustrate the swimming stability of a puller (stable) and pusher (unstable) swimming in the tube at Re = 0. At a finite Re, we find that the inertia and the tube constraint competitively affect the swimming stability of the squirmers and squirmer dumbbells. The puller and puller dumbbells swimming in the tube become unstable with increasing Re, whereas an unstable–stable–unstable evolution is found for the pusher and pusher dumbbells. With increasing κ, the puller and puller dumbbells become stable while the pusher and pusher dumbbells become unstable. In addition, we find that a greater ds yields a higher hydrodynamic efficiency η of the inertial squirmer dumbbell.