bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water‐Soluble Doubly‐Strapped Isolated Perylene Diimide Chromophore
Authors: Yang Fei , Li Ran , Wei Wei , Ding Xingwei , Xu Zhenzhen , Wang Ping , Wang Guo , Xu Yanqing , Fu Hongbing , Zhao Yanli 
Published: March 2022

AbstractPerylene diimides (PDIs), a well‐studied class of organic dyes, have a strong tendency to self‐aggregate in water, thus greatly restricting their phototheranostic applications. Herein, we report a water‐soluble PDI cyclophane “Gemini Box” (GBox‐14+), consisting of a central PDI chromophore enclosed by double‐sided cationic molecular straps. Owing to the effective spatial isolation, the chromophore self‐aggregation can be completely eliminated, even in a concentrated aqueous solution up to 2 mM. To our knowledge,GBox‐14+represents an interesting example of a fluorescent PDI cyclophane in water, capable of being employed for lysosome‐targetable live‐cell imaging. More importantly, the highly concentrated aqueous solution of PDI radical anion can be significantly stabilized byGBox‐14+to exhibit an excellent near‐infrared photothermal effect, which was further exploited for efficient and selective antibacterial applications. This work provides a new access to water‐soluble non‐aggregated organic dyes and promotes their potential biomedical applications.
Study of free‐surface and solids suspension in top‐sealed tanks stirred by pitched blade turbine impellers through DEM‐VOF method
Authors: Li Bao , Kang Qianqian , Wang Zechen , Wang Jingtao 
Published: March 2022

AbstractA coupled method of discrete element method (DEM) and volume of fluid (VOF) is applied to study the particle suspension in top‐sealed solid–liquid tanks with a free‐surface. VOF is used to track the gas–liquid free‐surface, and DEM is used to calculate the movement and interaction of particles. As the air between the cover and free‐surface in a sealed tank is very limited, the free‐surface evolution process that a big vortex is generated quickly and then shrinks to a smaller one in sealed stirred tanks is reported first in this paper. In addition, the effects of pitched blade turbine (PBT) with different blade pitched angles (including 30°, 45°, 60°, 75°, and 90°) on solid suspension, free‐surface, and power number are investigated. Finally, the relationships between particle motion and fluid flow during the stirring are studied carefully. Fluid flow plays a dominant role during the start‐up of the stirring; and then, due to the contact of particles, some particles could obtain the larger velocity than the fluid. The results obtained here are helpful to design the sealed stirred tanks with PBT.
Role for Granulocyte Colony‐Stimulating Factor in Neutrophilic Extramedullary Myelopoiesis in a Murine Model of Systemic Juvenile Idiopathic Arthritis
Authors: Malengier‐Devlies Bert , Bernaerts Eline , Ahmadzadeh Kourosh , Filtjens Jessica , Vandenhaute Jessica , Boeckx Bram , Burton Oliver , De Visscher Amber , Mitera Tania , Berghmans Nele , Verbeke Geert , Liston Adrian , Lambrechts Diether , Proost Paul , Wouters Carine , Matthys Patrick 
Published: March 2022

ObjectiveSystemic juvenile idiopathic arthritis (JIA) is a systemic inflammatory disease with childhood onset. Systemic JIA is associated with neutrophilia, including immature granulocytes, potentially driven by the growth factor granulocyte‐colony stimulating factor (G‐CSF). This study was undertaken to investigate the role of G‐CSF in the pathology of systemic JIA.MethodsInjection of Freund's complete adjuvant (CFA) in BALB/c mice induces mild inflammation and neutrophilia in wild‐type (WT) mice and a more pronounced disease, reminiscent to that of JIA patients, in interferon‐γ–knockout (IFNγ‐KO) mice. Extramedullary myelopoiesis was studied in CFA‐immunized mice by single‐cell RNA sequencing, and the effect of G‐CSF receptor (G‐CSFR) blockage on neutrophil development and systemic JIA pathology was evaluated. Additionally, plasma G‐CSF levels were measured in patients.ResultsBoth in systemic JIA patients and in a corresponding mouse model, plasma G‐CSF levels were increased. In the mouse model, we demonstrated that G‐CSF is responsible for the observed neutrophilia and extramedullary myelopoiesis and the induction of immature neutrophils and myeloid‐derived suppressor‐like cells. Administration of a G‐CSFR antagonizing antibody blocked the maturation and differentiation of neutrophils in CFA‐immunized mice. In IFNγ‐KO mice, treatment was associated with almost complete inhibition of arthritis due to reduced neutrophilia and osteoclast formation. Disease symptoms were ameliorated, but slight increases in interleukin‐6 (IL‐6), tumor necrosis factor, and IL‐17 were detected upon G‐CSFR inhibition in the IFNγ‐KO mice, and were associated with mild increases in weight loss, tail damage, and immature red blood cells.ConclusionWe describe the role of G‐CSF in a mouse model of systemic JIA and suggest an important role for G‐CSF–induced myelopoiesis and neutrophilia in regulating the development of arthritis.
Cationic Gold‐Catalyzed Intramolecular Cyclization of Substituted 1,5‐Diynes to Access Indenone Derivatives
Authors: Karunakar Galla V. , Raju Chittala Emmaniel , Sreenivasulu Gottam , Kumar Perla Bharath , Kadiyala Veerabhushanam , Sridhar Balasubramanian 
Published: March 2022

AbstractAn efficient intramolecular cyclization reaction was developed to achieve indenone derivatives. The substituted 1,5‐diyenes were converted to the corresponding indenones via a gold‐catalyzed organic transformation, and moderate to excellent yields of the title molecules were obtained via formation of two C=O and one C−C bonds under mild reaction conditions in one pot.
Molecular cloning and characterization of Cinnamoyl‐CoA reductase promoter gene from Asarum sieboldii Miq
Authors: Liu Fawang , Ali Tahir , Liu Zhong 
Published: March 2022

AbstractAsarum sieboldii Miq., a perennial herb of the family Aristolochiaceae, is widely used in China to treat cold, fever, aphthous stomatitis, toothache, gingivitis, and rheumatoid arthritis. Methyleugenol is the most representative pharmacological constituent of this medicinal herb. Cinnamoyl‐CoA reductase (CCR), which has been well known for occupying a critical position in the lignin biosynthesis pathway, is also shared with the biosynthesis of methyleugenol. To better understand the regulatory mechanisms of methyleugenol biosynthesis, a 1530‐bp long promoter region of the AsCCR1 gene was isolated. PLACE and PlantCARE analysis affirmed the existence of the core promoter elements such as TATA and CAAT boxes, abiotic stress‐responsive cis‐regulation elements like abscisic acid‐responsive element, G‐box, and MBS in the isolated sequence. The histochemical assay suggested that it was a constitutive promoter, highly expressed in the root tissue. Moreover, the region of −200 bp to ATG (start codon) was enough to drive the expression of It GUS gene. Treatments with low temperature and high concentration of gibberellin or abscisic acid demonstrated the abiotic stress‐induced expression of the AsCCR1 promoter. Overall, this study revealed the isolation and characterization of the AsCCR1 promoter. Moreover, it also provided a candidate gene for molecular breeding in A. sieboldii to enhance its pharmacological potential.
A Liquid‐Metal Electrocatalyst as a Self‐Healing Anchor to Suppress Polysulfide Shuttling in Lithium‐Sulfur Batteries
Authors: Fahad Saisaban , Zhang Zeyang , Zhai Lei , Kushima Akihiro 
Published: March 2022

AbstractLithium‐sulfur battery (LSB) is a promising next generation energy storage technology due to its high theoretical capacity, low cost, and environmental friendliness surpassing current lithium‐ion batteries. However, several challenges restrict the practical applications of LSBs. A major obstacle that limits its performance is the dissolution of long‐chain lithium polysulfides into the electrolyte which results in loss of active material and capacity fade during the charge/discharge cycles. Here, we developed a novel sulfur composite with liquid‐metal (LM) nanoparticles and reduced graphene oxide (rGO) dispensed on a carbon‐cloth electrode to achieve long cycling of LSBs. The liquid nature of the LM nanoparticles results in many advantages. It provides a strong anchoring with sulfur inhibiting the polysulfide shuttle effect. In addition, it prevents the detachment of the sulfur particles from the current collector albeit large volume changes and cracking of the sulfur during lithiation and delithiation, maintaining the electron conduction paths. This innovative composite resulted in a high discharge capacity, an outstanding capacity retention, and a high Coulombic efficiency. Our results demonstrate an effective method to suppress the polysulfide shuttle effect and pave a new path towards practical applications of LSBs by using multifunctional LM nanoparticles composites.
Perfectionism paradox: Perfectionistic concerns (not perfectionistic strivings) affect the relationship between perceived risk and choice
Authors: Ceylan Gizem , Kolsarici Ceren , MacInnis Deborah J. 
Published: March 2022

AbstractWe investigate whether, when, and why perfectionism moderates the relationship between perceived risk and choice. Two studies (N = 1784) using different choice domains (appearance and performance) and different samples (women and general population) show consistent results. People with high (vs. low) perfectionistic concerns (PC) are less sensitive to high risks and, hence, are more willing to consider options (i.e., products and services) that entail greater risks. These effects emerge because high‐PC (vs. low‐PC) individuals have more favorable appraisals, believing that the product or service's benefits are worth its risks even when these risks are substantial. The effects observed for high‐ vs. low‐PC do not obtain for people who are high (vs. low) on a second dimension of perfectionism called perfectionistic strivings (PS). Our findings suggest that high‐PC individuals may be a vulnerable segment in society, particularly since (a) people are frequently confronted with decisions about options that promise perfectionistic outcomes, (b) these options can come with high levels of risk, and (c) perfectionistic tendencies have become more prevalent over time. We discuss the implications of these findings for policymakers and future research.
Switchable DNA‐Based Peroxidases Controlled by a Chaotropic Ion**
Authors: Hoog Tanner G. , Pawlak Matthew R. , Aufdembrink Lauren M. , Bachan Benjamin R. , Galles Matthew B. , Bense Nicholas B. , Adamala Katarzyna P. , Engelhart Aaron E. 
Published: March 2022

AbstractHere we demonstrate a switchable DNA electron‐transfer catalyst, enabled by selective destabilization of secondary structure by the denaturant, perchlorate. The system is comprised of two strands, one of which can be selectively switched between a G‐quadruplex and duplex or single‐stranded conformations. In the G‐quadruplex state, it binds hemin, enabling peroxidase activity. This switching ability arises from our finding that perchlorate, a chaotropic Hofmeister ion, selectively destabilizes duplex over G‐quadruplex DNA. By varying perchlorate concentration, we show that the DNA structure can be switched between states that do and do not catalyze electron‐transfer catalysis. State switching can be achieved in three ways: thermally, by dilution, or by concentration.
Norethisterone‐induced cholestasis: A case report
Authors: Moussaoui Safa , Abdelwahed Mehdi , Ben Chaaben Nabil , Bellalah Ahlem , Ben Fadhel Najah , Guediche Arwa , Zakhama Mejda , Tababi Ramzi , Aouam Karim , Abdelfattah Zakhama , Loghmari Hichem , Safer Leila 
Published: March 2022

AbstractCase presentationThis case report concerns a 49‐year‐old woman who developed cholestasis (build‐up of bile in the liver) two months and a half after initiating norethisterone, progestin‐only pills, which resolved after the withdrawal of these pills.
Epstein–Barr virus mucocutaneous ulcer followed by Hodgkin lymphoma in multiple myeloma patient
Authors: Forster Moriah , Fedoriw Yuri , Tuchman Sascha , Grover Natalie 
Published: March 2022

AbstractEpstein–Barr virus mucocutaneous ulcers (EBV MCU) are B‐cell lymphoproliferative disorders associated with immunosuppression. We report EBV MCU in a multiple myeloma patient on lenalidomide maintenance after stem cell transplant that resolved with decreased immunosuppression. Furthermore, the subsequent development of classical Hodgkin lymphoma suggests an underlying predisposition to EBV‐driven lymphoproliferative disorders.
Disseminated peritoneal leiomyomatosis as an incidental finding: A case report
Authors: Morgan Emmanuel D , Kahiye Mohamed , Kule Isaiah , Yahaya James J , Othieno Emmanuel 
Published: March 2022

AbstractWe present the case of a 23‐year‐old female with multiple diffuse and nodular masses of different sizes involving predominantly the posterior wall of the uterus, omentum, and peritoneum which were histopathologically confirmed to be disseminated peritoneal leiomyomatosis. Meticulous investigation and accurate diagnosis are of utmost importance for the establishment of the correct diagnosis. Additionally, proper management of the patient while considering choice of the patients including close follow‐up of the patients is mandatory for the reason of ensuring early detection of recurrence.
Catalytic Asymmetric Isomerization of (Homo)Allylic Alcohols: Recent Advances and Challenges
Authors: Zhang Xue‐Xin , Zhang Ying , Liao Ling , Gao Yang , Su Heng E. M. , Yu Jin‐Sheng 
Published: March 2022

AbstractCatalytic asymmetric isomerization of allylic or homoallylic alcohols into synthetically useful carbonyl compounds is a redox‐neutral and 100 % atom‐economic transformation, which is of great interest and has gained increasing attention from both academic and industry. This minireview summarizes the advances in catalytic enantioselective isomerization and it involved tandem reactions over the past five years, also discusses their advantages and limitations, and expounds the synthetic chances still open for further development.
Single Crystals of Mixed‐Cation Copper‐Based Perovskite with Trimodal Bandgap Behavior
Authors: Elattar Amr , Li Wenhui , Suzuki Hiroo , Kambe Takashi , Nishikawa Takeshi , Kyaw Aung Ko Ko , Hayashi Yasuhiko 
Published: March 2022

AbstractTwo‐dimensional (2D) hybrid perovskites with novel functionalities and structural diversity are a perfect platform for emerging optoelectronic devices such as photodetectors, light‐emitting diodes, and solar cells. Here, we demonstrate that excess concentration of Cesium bromide (CsBr) is key to the formation of easily exfoliated 2D Cs2Cu(Cl/Br)4 perovskite crystal. Furthermore, by employing this trick to 2D perovskite MA2Cu(Cl/Br)4 (MA=methylammonium), we achieve a phase‐pure easily exfoliated 2D mixed‐cation (MA/Cs)2Cu(Cl/Br)4 perovskite crystal, which exhibits reduced bandgap (1.53 eV) with ferromagnetic behavior and photovoltaic property. The resultant mixed‐cation structured device reveals enhanced efficiency compared to all MA and all Cs counterparts. These findings demonstrate the importance of cation‐engineering in developing innovative materials with novel properties.
Luminescent Thin Films Enabled by CsPbX3 (X=Cl, Br, I) Precursor Solution
Authors: Liu Yue , Wang Yuxiang , Cheng Haoran , Ma Zheng , Li Qian , Wang Gang , Pan Daocheng , Wang Limin , Ming Jun 
Published: March 2022

AbstractInorganic cesium lead halide perovskite nanocrystals are candidates for lighting and display materials due to their outstanding optoelectronic properties. However, the dissolution issue of perovskite nanocrystals in polar solvents remains a challenge for practical applications. Herein, we present a newly designed one‐step spin‐coating strategy to prepare a novel multicolor‐tunable CsPbX3 (X=Cl, Br, I) nanocrystal film, where the CsPbX3 precursor solution was formed by dissolving PbO, Cs2CO3, and CH3NH3X into the ionic liquid n‐butylammonium butyrate. The as‐designed CsPbX3 nanocrystal films show high color purity with a narrow emission width. Also, the blue CsPb(Cl/Br)3 film demonstrates an absolute photoluminescence quantum yields (PLQY) of 15.6 %, which is higher than 11.7 % of green CsPbBr3 and 8.3 % of red CsPb(Br/I)3 film. This study develops an effective approach to preparing CsPbX3 nanocrystal thin films, opening a new avenue to design perovskite nanocrystals‐based devices for lighting and display applications.
Impact of Heterocycle Annulation on NIR Absorbance in Quinoid Thioacene Derivatives
Authors: Hou Peng , Peschtrich Sebastian , Huber Nils , Feuerstein Wolfram , Bihlmeier Angela , Krummenacher Ivo , Schoch Roland , Klopper Wim , Breher Frank , Paradies Jan 
Published: March 2022

AbstractThe synthesis and characterisation of a homologous series of quinoid sulfur‐containing imidazolyl‐substituted heteroacenes is described. The optoelectronic and magnetic properties were investigated by UV/vis, fluorescence and EPR spectroscopy as well as quantum‐chemical calculations, and were compared to those of the corresponding benzo congener. The room‐temperature and atmospherically stable quinoids display strong absorption in the NIR region between 678 and 819 nm. The dithieno[3,2‐b:2′,3′‐d]thiophene and the thieno[2′,3′:4,5]thieno[3,2‐b]thieno[2,3‐d]thiophene derivatives were EPR active at room temperature. For the latter, variable‐temperature EPR spectroscopy revealed the presence of a thermally accessible triplet state, with a singlet‐triplet separation of 14.1 kJ mol−1.
Adsorption and removal studies of cadmium ion onto sulphonic/phosphonic acid functionalization resins
Authors: Elfeghe Salem , Anwar Shams , Zhang Yahui 
Published: March 2022

AbstractCadmium is a persistent bio‐accumulative toxic metallic element, which causes hazardous impacts on living species, water, and the environment. This paper presents the study of cadmium ion removal from aqueous solutions in batch experiments using 22 ion exchange resins with different functional groups. It was found that Dowex G‐26 resin with a sulphonic functional group and Puromet™ MTS9570 resin with sulphonic and phosphonic functional groups had excellent performance for Cd (II) ion removal. The effects of resin dosage, adsorption time, initial concentration of cadmium, and initial pH of solution on cadmium removal were investigated systematically using Dowex G‐26 and Puromet™ MTS9570 resins. Maximum cadmium removal rates of 99.2% and 98.9% were achieved for G‐26 and MTS9570, respectively, at an initial cadmium concentration of 1000 mg/L, an initial solution pH of 5.0, an adsorption time of 30 min, and a 0.01 mg/L resin dosage for G‐26, and a 0.025 mg/L resin dosage for MTS9570. The ion‐exchange adsorption process was fast, and it reached equilibrium after 30 min of adsorption. The results obtained show that both resins performed well for the removal of Cd (II) ions from weakly acidic solutions. Langmuir, Freundlich, and Temkin isotherms models were employed to investigate and understand the adsorption characteristics. The results showed that the studied adsorption processes fitted well to the Langmuir adsorption isotherm. From the Langmuir adsorption isotherm, the maximum adsorption capacities of Cd (II) were found to be 78.125 and 51.020 mg/g for G‐26 and MTS9570, respectively. This research provides an efficient systemic approach for cadmium ion removal from aqueous solutions.
Biliary cytology: A diagnostic tree for adenocarcinoma based on a cohort of 135 patients with endoscopic retrograde cholangiopancreatography for stenosis of the extrahepatic bile duct
Authors: Giovannini Diane , Bailly Adeline , Seigneurin Arnaud , Fior‐Gozlan Michèle , Eyraud Pierre‐Yves , Roth Gael , Laverrière Marie‐Hélène , McLeer Anne , Sturm Nathalie 
Published: March 2022

BACKGROUNDThe diagnosis of well‐differentiated adenocarcinoma on bile aspiration is a well‐known challenge. This study was aimed at improving the diagnostic performance and providing a biliary cytology learning atlas.METHODSThis single‐center, retrospective study included 135 cases of informative biliary samples collected between 2009 and 2018 that were classified as benign, atypical, or malignant. A double assessment was performed by a novice and a cytopathologist experienced in biliary cytology to establish the specificities, sensitivities, and inter‐ and intraobserver κ index agreements of 24 cytological criteria, which were illustrated in a learning atlas.RESULTSA multivariate logistic regression was used to assess whether the most specific and reproducible criteria were associated with malignancy. A scoring system was statistically determined: 6 points were attributed in the presence of a 3‐dimensional (3D) cluster, anisonucleosis, and a nuclear to cytoplasmic (N:C) ratio > 0.5, whereas 4 points were given in the presence of an enhanced nuclear membrane. A score higher than 10 points resulted in a malignancy diagnosis with 96% sensitivity and 97% specificity.CONCLUSIONSA diagnostic tree of malignancy based on 4 criteria, together with a multidisciplinary approach, allows the diagnosis of adenocarcinoma with a specificity of 100% and a sensitivity of 88% or 72% depending on the presence of a single malignant cell or the presence of 3 combined criteria (a 3D cluster, anisonucleosis, and an N:C ratio > 0.5). It comes with a learning atlas useful for cytopathologist training and accuracy in this uncommon cytology.;
Formation of Temporary Negative Ions and Their Subsequent Fragmentation upon Electron Attachment to CoQ0 and CoQ0H2
Authors: Ameixa João , Arthur‐Baidoo Eugene , Pereira‐da‐Silva João , Ruivo Júlio C. , T. do N. Varella Márcio , Beyer Martin K. , Ončák Milan , Ferreira da Silva Filipe , Denifl Stephan 
Published: March 2022

AbstractThe front cover artwork is provided by Prof. Stephan Denifl's group at the University of Innsbruck, Austria, in collaboration with Prof. Filipe Ferreira da Silva's group at NOVA University Lisbon, Portugal, and Prof. Dr. Márcio Varella's group at University of São Paulo, Brazil, as well as with Prof. Dr. Martin Beyer and Prof. Dr. Milan Ončak also at the University of Innsbruck, Austria. The image shows the main fragmentation pathways of both coenzyme Q0 (CoQ0) and CoQ0H2 upon electron attachment in the gas phase. Read the full text of the Research Article at 10.1002/cphc.202100834.
Mesocarbon Microbeads Boost the Electrochemical Performances of LiFePO4||Li4Ti5O12 through Anion Intercalation
Authors: Cheng Zhenjie , Wang Chenggang , Zhu Yansong , Wang Cheng , Jiang Xiaolei , Qian Zhao , Chen Bo , Yang Jian 
Published: March 2022

AbstractLi‐ion batteries with LiFePO4 cathode and Li4Ti5O12 anode show promise for storing renewable energy. However, their low output voltage results in a low energy density. In contrast, dual‐ion batteries with graphite cathode and Li4Ti5O12 anode can achieve a high output voltage of >3.0 V. In this study, mesocarbon microbeads (MCMB)@LiFePO4||Li4Ti5O12 dual‐ion batteries are developed to address these issues. In the cathode, MCMB improves the conductivity of LiFePO4 and increases the output voltage by the intercalation of anions in the cell voltage range of 2.1–3.5 V. Moreover, the LiFePO4 shell sustains the structural integrity of MCMB and generates in situ a cathode‐electrolyte interphase (CEI) with rich LiF. Owing to these unique compositional and structural features, MCMB@LiFePO4||Li4Ti5O12 manifests much better electrochemical performance than LiFePO4||Li4Ti5O12 and MCMB||Li4Ti5O12. It sustains 89.6 % of the initial capacity after 1200 cycles at 0.2 A g−1 and achieves a specific energy up to 128 Wh kg−1 at 179 W kg−1.