bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beliefs and perceptions of patient safety event reporting in a Canadian Emergency Department: a qualitative study
Authors: Skutezky Trevor , Small Serena S. , Peddie David , Balka Ellen , Hohl Corinne M. 
Published: November 2022

Abstract
Objectives
Patient safety events (PSEs) are unwanted or unexpected events that occur during medical care. High cognitive loads and frequent interruptions make emergency departments (EDs) uniquely error prone environments. Yet, frontline clinicians rarely report PSEs using incident reporting systems. The incidence, severity, and preventability of PSEs thus remain poorly understood, and contributing factors are understudied. We sought to understand ED staff beliefs and perceptions about their PSE reporting system and what features they believe are important in such a system.

Methods
We conducted a qualitative study among healthcare providers working in the ED and departmental leadership. We recruited participants via email and held a series of interviews, focus groups, and participatory workshops. We iteratively analyzed the data using the constant comparative method and used thematic analysis to establish themes.

Results
50 participants attended at least one focus group, interview, or workshop. Participants perceived that PSE reporting through formal channels in the ED was challenging. Clinicians had an inherent desire to report PSEs and do so through numerous informal channels, yet underreported in formal reporting systems. The current PSE reporting system did not meet frontline staff needs and was viewed as ineffective in improving care quality and safety. We identified three key features for an improved PSE reporting system: (1) clear definitions; (2) transparency; and (3) simplicity.

Conclusions
In this study, we have identified ideal features for PSE reporting processes to meet the needs of both frontline staff and departmental leadership based on perceptions of current PSE reporting practices. Improved PSE reporting processes have the potential to increase PSE reporting in the ED overall, increasing the availability of information about PSEs to support quality improvement and improve patient safety.
A new control problem? Humanoid robots, artificial intelligence, and the value of control
Authors: Nyholm Sven 
Published: November 2022

AbstractThe control problem related to robots and AI usually discussed is that we might lose control over advanced technologies. When authors like Nick Bostrom and Stuart Russell discuss this control problem, they write in a way that suggests that having as much control as possible is good while losing control is bad. In life in general, however, not all forms of control are unambiguously positive and unproblematic. Some forms—e.g. control over other persons—are ethically problematic. Other forms of control are positive, and perhaps even intrinsically good. For example, one form of control that many philosophers have argued is intrinsically good and a virtue is self-control. In this paper, I relate these questions about control and its value to different forms of robots and AI more generally. I argue that the more robots are made to resemble human beings, the more problematic it becomes—at least symbolically speaking—to want to exercise full control over these robots. After all, it is unethical for one human being to want to fully control another human being. Accordingly, it might be seen as problematic—viz. as representing something intrinsically bad—to want to create humanoid robots that we exercise complete control over. In contrast, if there are forms of AI such that control over them can be seen as a form of self-control, then this might be seen as a virtuous form of control. The “new control problem”, as I call it, is the question of under what circumstances retaining and exercising complete control over robots and AI is unambiguously ethically good.
Experiences of clinical teaching-learning among medical and nursing graduates during internship and their supervisors in Tanzania
Authors: Mselle Lilian Teddy , Tarimo Edith A. M. , Mloka Doreen , Mkoka Dickson Ally , Dika Haruna , Laisser Rose Mjawa , Sirili Nathanael , Martin-Holland Judy 
Published: November 2022

AbstractBackgroundHealth professions training in Tanzania has gradually adopted the competency-based curricula (CBC) approach that focuses on learners’ acquisition of competencies in knowledge skills and aptitude. Feedback from the graduates is crucial for improving CBC implementation and review to ensure that graduates acquire clinical competencies and thus improve patient care.ObjectivesTo explore the teaching–learning experiences of medical and nursing graduates during their internship and their supervisors in three teaching hospitals.MethodsExploratory qualitative data from in-depth interviews and focus group discussions were analysed using a content analysis framework. Medical and nursing graduates who were in an internship program in three teaching hospitals in Tanzania were conveniently recruited based on their availability during the data collection period.ResultsThe use of clinical logbooks, guidelines and protocols, bedside teaching, mentorship, and supervision were important for the acquisition of clinical competencies. Graduates demonstrated inadequate clinical competency including confidence, commitment, and professionalism because of a lack of clear clinical guidelines and protocols, inadequate bedside teaching including supervision by faculty and ineffective communication and feedback.ConclusionsClinical teaching–learning tools and approaches facilitate students’ acquisition of clinical competencies. However, inadequate use of guidelines and protocols, bedside teaching, clinical supervision and effective communication was observed. Use of these clinical teaching approaches should be emphasized for students’ clinical competency acquisition.
Privacy, the Housing Research Unit at the University of Edinburgh and the Courtyard House, 1959–70
Authors: Fair Alistair 
Published: November 2022

ABSTRACTWith a focus on post-war Britain (and Scotland in particular), this article contributes to the literature on the history of ’community’ by examining its apparent inverse, namely privacy. In particular, it explores the interest that emerged in 1960s Britain in a type of housing that was considered to provide enhanced privacy for residents — the courtyard house. The article begins by looking at the ways in which privacy was considered in official documentation on homes and housing in the post-war period in both England and Wales, and Scotland. It then turns to the work of the University of Edinburgh’s Housing Research Unit in the 1960s, which included not just the design and construction of housing schemes, but also social investigation of the built results. The article examines the ’urban’ housing designed in Cumbernauld and the ’rural’ counterpart in Prestonpans, both of which were intended to provide enhanced privacy for residents. It then looks at the unit’s evaluation of the completed courtyard housing built at Prestonpans as well as another survey undertaken in Dundee, both of which explored the residents’ experience of privacy. Overall, the article argues that the idea of privacy, as understood by designers and experienced by residents, played an important role in post-war housing, as part of the ambition not just to improve standards, but also to provide new choices.
The First Draft of Serlio’s Sixth Book and its Arrival in Britain, c. 1700
Authors: Campbell Ian 
Published: November 2022

ABSTRACTThis article explores the provenance of the first draft of Sebastiano Serlio’s sixth book, on dwellings, written in the 1540s. It was acquired by the Avery Library at Columbia University, New York, a century ago and published for the first time in 1978. The article proposes that the manuscript and drawings remained in the vicinity of Paris until the late seventeenth century, when they were mounted and bound into an album that may have been sold by a descendant of Jacques Androuet du Cerceau I, either in Paris or the Netherlands. It goes on to demonstrate that, in the early eighteenth century, the manuscript was owned by Francis Bird, a leading British sculptor of his day, who collaborated with leading architects including Christopher Wren, James Gibbs and, possibly, Nicholas Hawksmoor.
French Sinology
Authors: Will Pierre-Étienne 
Published: November 2022

AbstractThe history of French Sinology—that is, of scholarly research on things Chinese by French-speaking authors working from Chinese sources—goes back to the seventeenth century and can be divided into several periods determined in large part by sociopolitical factors, and marked by different approaches and emphases: I propose to describe them as the missionary age (seventeenth–eighteenth centuries); the first academic efflorescence (nineteenth century); the advent of field research and the impact of colonialism and the social sciences (first half of twentieth century); and the postwar era of specialization and internationalization (second half of twentieth century), which marked the end of a certain French domination of Chinese studies in the West.1
DISCERNING THE FORM AT THE SECOND STAGE OF VICARIOUS LIABILITY
Authors: Beuermann Christine 
Published: November 2022

AbstractThis article uses Atiyah and Summer's categorisation of the attributes of formal legal reasoning in Form and Substance in Anglo-American Law to examine the type of legal reasoning process used by the courts in England and Wales when determining the second stage of vicarious liability. The analysis shows that, although remaining formal in nature, the shift away from the Salmond test has resulted in a shift in the type of form used by the courts. It is suggested that future guidance issued by the Supreme Court to lower courts when determining the second stage of vicarious liability needs to take account of this change for the guidance to be effective.
Developing teacher curriculum design expertise: using the CDC Model in the music classroom
Authors: McPhail Graham , Tibbles Sally , Cornish Mary 
Published: November 2022

AbstractThe purpose of this paper is to discuss the impact of the Curriculum Design Coherence Model (CDC Model – Rata, 2019) on the design practice of two music teachers in a middle school music class in New Zealand. The CDC Model proposes that deep learning first requires deep design coherence. This coherence is generated by three interrelated design dimensions: (i) the ‘surfacing’ of epistemic structure, (ii) the use of subject concepts and (iii) the interrelationship between ‘knowledge-that’ (knowledge of something) and ‘know-how-to’ (knowing how to do something with that knowledge of something). We discuss how the model has been put to use in the design of a song writing unit of work for students aged 10–12 years in a general music class and note the impact of the model on the developing design expertise of the two music teachers involved in a wider research project.
Observational Evidence of Increasing Compound Tropical Cyclone‐Moist Heat Extremes in India
Authors: Rajeev Akshay , Mishra Vimal 
Published: November 2022

AbstractMoist heat stress can lead to the inability of the human body to cool itself due to the impact of high temperature and humidity. The co‐occurrence of tropical cyclones (TCs) and moist heat stress has considerable implications for India's dense population and infrastructure. However, the crucial linkage between TCs and moist heat extremes remains unrecognized. We used the cyclone eAtlas and ERA5 reanalysis to examine the temporally compounding TC and moist heat extremes over India from 1980 to 2021. We find that TC‐Heat stress events in India have increased recently, which can be attributed to the high‐intensity TCs originating from the Arabian Sea. The risk of TC‐Heat stress events is higher (than in other parts of the world) in India due to an overlap of peak moist heat and TCs occurrence during the pre‐monsoon (April–June) season. Landfalling TCs alter the thermodynamic environment causing the moist heat to peak over the region with increased frequency and intensity. The direct and compounded influence of TCs on moist heat can have substantial implications.
Particulate Trace Metal Sources, Cycling, and Distributions on the Southwest African Shelf
Authors: Al‐Hashem Ali A. , Beck Aaron J. , Krisch Stephan , Menzel Barraqueta Jan‐Lukas , Steffens Tim , Achterberg Eric P. 
Published: November 2022

AbstractWe present labile (L‐pTM) and refractory (R‐pTM) particulate trace metal distributions of Fe, Mn, Al, Ti, Co, Zn, Cd, Ni, Pb, Cu, and P for a transect along the southwest African shelf and an off‐shore section at 3°S of the GEOTRACES GA08 section cruise. Particle sources and biogeochemical cycling processes are inferred using particle‐type proxies and elemental ratios. Enhanced concentrations of bio‐essential L‐pTMs (Zn, Cu, Ni, Cd, Co, and P) were observed in the Benguela upwelling region, attributed to enhanced primary production. Bio‐essential pTM stoichiometric ratios (normalized to pP) were consistent with phytoplankton biomass across the transect, except for Fe and Mn, which included adsorbed and labile oxide phases. Low pP lability (∼41%) suggests a potential refractory biogenic source on the Benguela shelf. Variable labilities observed between stations along the transect indicated potentially different biogenic pP labilities among different plankton groups. Benthic resuspension was prevalent in (near‐)bottom waters along the transect and formed an important source of Fe and Mn oxides. Lithogenic particles along the entire shelf were Mn deficient and particles on the Benguela shelf were enriched in Fe, consistent with regional sediment compositions. Enhanced available‐Fe (dissolved + labile particulate Fe) concentrations (up to 39.6 nM) were observed in oxygen‐deficient (near‐)bottom waters of the Benguela shelf coinciding with low L‐pMn. This was attributed to the faster oxidation kinetics of Fe, allowing Fe‐oxide precipitation and retention on the shelf, while Mn oxidation was slower. Enhanced L‐pFe in the Congo River plume, which comprised as much as 93% of the available‐Fe pool, was attributed to increased scavenging and formation of Fe oxides. Increased scavenging of other particle‐reactive trace metals (TMs) (Mn, Al, and Pb) was also apparent in Congo‐influenced waters. However, particles did not play a significant role in transporting TMs off‐shelf within Congo plume waters.
Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation
Authors: Stubbs Felicity E. , Flynn Benjamin P. , Rivers Caroline A. , Birnie Matthew T. , Herman Andrew , Swinstead Erin E. , Baek Songjoon , Fang Hai , Temple Jillian , Carroll Jason S. , Hager Gordon L. , Lightman Stafford L. , Conway-Campbell Becky L. 
Published: November 2022

AbstractARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function has been putatively linked to glucocorticoid resistance. Here, we interrogate the impact of siRNA knockdown of ARID1a compared to a functional interference approach in the HeLa human cervical cancer cell line. We report that ARID1a knockdown resulted in a significant global decrease in chromatin accessibility in ATAC-Seq analysis, as well as affecting a subset of genome-wide GR binding sites determined by analyzing GR ChIP-Seq data. Interestingly, the specific effects on gene expression were limited to a relatively small subset of glucocorticoid-regulated genes, notably those involved in cell cycle regulation and DNA repair. The vast majority of glucocorticoid-regulated genes were largely unaffected by ARID1a knockdown or functional interference, consistent with a more specific role for ARID1a in glucocorticoid function than previously speculated. Using liquid chromatography-mass spectrometry, we have identified a chromatin-associated protein complex comprising GR, ARID1a, and several DNA damage repair proteins including P53 binding protein 1 (P53BP1), Poly(ADP-Ribose) Polymerase 1 (PARP1), DNA damage-binding protein 1 (DDB1), DNA mismatch repair protein MSH6 and splicing factor proline and glutamine-rich protein (SFPQ), as well as the histone acetyltransferase KAT7, an epigenetic regulator of steroid-dependent transcription, DNA damage repair and cell cycle regulation. Not only was this protein complex ablated with both ARID1a knockdown and functional interference, but spontaneously arising DNA damage was also found to accumulate in a manner consistent with impaired DNA damage repair mechanisms. Recovery from dexamethasone-dependent cell cycle arrest was also significantly impaired. Taken together, our data demonstrate that although glucocorticoids can still promote cell cycle arrest in the absence of ARID1a, the purpose of this arrest to allow time for DNA damage repair is hindered.
Higher blood pressure in adolescent boys after very preterm birth and fetal growth restriction
Authors: Liefke Jonas , Steding-Ehrenborg Katarina , Sjöberg Pia , Ryd Daniel , Morsing Eva , Arheden Håkan , Ley David , Hedström Erik 
Published: November 2022

Abstract
Background
Although preterm birth predisposes for cardiovascular disease, recent studies in children indicate normal blood pressure and arterial stiffness. This prospective cohort study therefore assessed blood pressure and arterial stiffness in adolescents born very preterm due to verified fetal growth restriction (FGR).

Methods
Adolescents (14 (13–17) years; 52% girls) born very preterm with FGR (preterm FGR; n = 24) and two control groups born with appropriate birth weight (AGA), one in similar gestation (preterm AGA; n = 27) and one at term (term AGA; n = 28) were included. 24-hour ambulatory blood pressure and aortic pulse wave velocity (PWV) and distensibility by magnetic resonance imaging were acquired.

Results
There were no group differences in prevalence of hypertension or in arterial stiffness (all p ≥ 0.1). In boys, diastolic and mean arterial blood pressures increased from term AGA to preterm AGA to preterm FGR with higher daytime and 24-hour mean arterial blood pressures in the preterm FGR as compared to the term AGA group. In girls, no group differences were observed (all p ≥ 0.1).

Conclusions
Very preterm birth due to FGR is associated with higher, yet normal blood pressure in adolescent boys, suggesting an existing but limited impact of very preterm birth on cardiovascular risk in adolescence, enhanced by male sex and FGR.

Impact

Very preterm birth due to fetal growth restriction was associated with higher, yet normal blood pressure in adolescent boys.

In adolescence, very preterm birth due to fetal growth restriction was not associated with increased thoracic aortic stiffness.

In adolescence, very preterm birth in itself showed an existing but limited effect on blood pressure and thoracic aortic stiffness.

Male sex and fetal growth restriction enhanced the effect of preterm birth on blood pressure in adolescence.

Male sex and fetal growth restriction should be considered as additional risk factors to that of preterm birth in cardiovascular risk stratification.
Progress and priorities in reducing the time to cancer diagnosis
Authors: Nicholson B. D. , Lyratzopoulos G. 
Published: November 2022

AbstractKey developments in early diagnosis research and policy since the publication of the highly cited BJC review “Is increased time to diagnosis and treatment associated with poorer outcomes?” by Neal et al. in 2015 are summarised. Progress achieved since 2015 is described and priorities for further research identified.
Genetic prediction of male pattern baldness based on large independent datasets
Authors: Chen Yan , Hysi Pirro , Maj Carlo , Heilmann-Heimbach Stefanie , Spector Timothy D. , Liu Fan , Kayser Manfred 
Published: November 2022

AbstractGenetic prediction of male pattern baldness (MPB) is important in science and society. Previous genetic MPB prediction models were limited by sparse marker coverage, small sample size, and/or data dependency in the different analytical steps. Here, we present novel models for genetic prediction of MPB based on a large set of markers and large independent subsample sets drawn among 187,435 European subjects. We selected 117 SNP predictors within 85 distinct loci from a list of 270 previously MPB-associated SNPs in 55,573 males of the UK Biobank Study (UKBB). Based on these 117 SNPs with and without age as additional predictor, we trained, by use of different methods, prediction models in a non-overlapping subset of 104,694 UKBB males and tested them in a non-overlapping subset of 26,177 UKBB males. Estimates of prediction accuracy were similar between methods with AUC ranges of 0.725–0.728 for severe, 0.631–0.635 for moderate, 0.598–0.602 for slight, and 0.708–0.711 for no hair loss with age, and slightly lower without, while prediction of any versus no hair loss gave 0.690–0.711 with age and slightly lower without. External validation in an early-onset enriched MPB dataset from the Bonn Study (N = 991) showed improved prediction accuracy without considering age such as AUC of 0.830 for no vs. any hair loss. Because of the large number of markers and the large independent datasets used for the different analytical steps, the newly presented genetic prediction models are the most reliable ones currently available for MPB or any other human appearance trait.
Viral load dynamics of SARS-CoV-2 Delta and Omicron variants following multiple vaccine doses and previous infection
Authors: Woodbridge Yonatan , Amit Sharon , Huppert Amit , Kopelman Naama M. 
Published: November 2022

AbstractAn important aspect of vaccine effectiveness is its impact on pathogen transmissibility, harboring major implications for public health policies. As viral load is a prominent factor affecting infectivity, its laboratory surrogate, qRT-PCR cycle threshold (Ct), can be used to investigate the infectivity-related component of vaccine effectiveness. While vaccine waning has previously been observed for viral load during the Delta wave, less is known regarding how Omicron viral load is affected by vaccination status, and whether vaccine-derived and natural infection protection are sustained. By analyzing results of more than 460,000 individuals, we show that while recent vaccination reduces Omicron viral load, its effect wanes rapidly. In contrast, a significantly slower waning rate is demonstrated for recovered COVID-19 individuals. Thus, while the vaccine is effective in decreasing morbidity and mortality, its relatively small effect on transmissibility of Omicron (as measured here by Ct) and its rapid waning call for reassessment of future booster campaigns.