bluuebunny/crossref_metadata_2025_split huggingface dataset:
High fibrinogen levels are associated with poor survival in patients with liposarcoma
Authors: Peschek Leonie S. , Hobusch Gerhard M. , Funovics Philipp T. , Willegger Madeleine , Schmid Maximilian P. , Amann Gabriele , Lamm Wolfgang , Brodowicz Thomas , Ay Cihan , Windhager Reinhard , Panotopoulos Joannis 
Published: December 2022

Abstract
Purpose
The aim of this study was to evaluate whether (preoperative) plasma levels of fibrinogen, an essential clotting and acute phase protein, are associated with the prognosis of patients with a liposarcoma, a subtype of sarcoma derived from adipose tissue.
Methods
We performed a retrospective cohort study of 158 patients with liposarcoma treated at the Department of Orthopaedics of the Medical University of Vienna in Austria from May 1994 to October 2021. Kaplan-Meier curves as well as uni- and multivariable Cox proportional hazard models were performed to evaluate the association between fibrinogen levels and overall survival.
Results
Elevated fibrinogen was associated with adverse overall survival in cause specific hazards analysis of mortality (hazard ratio [HR] per 10g/L increase: 1,04; 95% CI 1,02–1,06; p < 0,001). This association prevailed in multivariable analysis after adjustment for AJCC tumor stage (HR 1,03; 95% CI 1.01–1.05; p = 0.013).
Conclusions
Increasing levels of fibrinogen, a routinely available and inexpensive parameter, predicts the risk of mortality in patients with liposarcoma.
The effect of dry needling compared to lumbar spine mobilization on pain, functional disability, quadratus lumborum and lumbar multifidus function, lumbar range of motion and pain pressure threshold in patients with non-specific chronic low back pain: Study protocol for a randomized controlled trial
Authors: Mirzaie Hamide , Pourahmadi Mohammad Reza , Ayoubpour Mohamad reza , firouze bahare 
Published: December 2022

Abstract
Background: Low back pain (LBP) is a socioeconomic burden worldwide and a major contributor to health-care costs. Mobilization and dry needling (DN) are well-known treatments for LBP. Just one study has compared these two treatments with each other which has some limitations, therefore the purpose of this study is to compare them to each other.
Methods and study design: The study is a two-arm randomized, double-blind, double-dummy, controlled trial comparing DN to lumbar spine mobilization in individuals (n=56; 18–45 years of age) with chronic non-specific LBP (CNLBP). The experimental group will receive DN plus sham mobilization and the control group will receive Maitland’s anterior-posterior mobilization plus sham DN. Both groups will receive exercise and low-power laser. The primary outcomes are pain and functional disability, and the secondary outcomes are lumbar multifidus and quadratus lumborum function, lumbar range of motion, pain pressure threshold, DN side effects, and patient adherence to treatment. Primary and secondary outcomes will be assessed at baseline and 3 to 7 days after the final treatment session. Recruitment will begin immediately after acceptance of the protocol and it will take 5 to 6 months to complete the study.
Discussion: In this study, we intend to solve the methodological problems of the previous study in this field. The results of this study allow the therapist to choose an intervention that has more therapeutic effects in combination with routine physiotherapy in the treatment of patients with CNLBP.
Trial registration: 1) ClinicalTrials.gov registration number: NCT05214456. 2) IRCT.ir registration number: IRCT20210706051802N1.
Co2 emission analysis of metakaolin and alccofine replaced concrete in m40 grade concrete
Authors: chandar sekaran prakash , Raganathan Santhosh 
Published: December 2022

Abstract
Among the largest CO2 emission industries, the cement industry is ranked at 2nd place. Large volume of CO2 is emitted at the clinker production, which is a cement manufacturing intermediate product. Countries around the world were having difficulty reducing atmospheric emissions of greenhouse gases (GHG). Concrete is still being used more and more as the nation's infrastructure advances. The amount of CO2 emitted by concrete can be decreased by using less cement or substituting other materials for cement. In this study the CO2 emission analysis is made on M40 grade, which is metakaolin (MK) and alccofine (AL) replaced concrete and is compared with the conventional concrete. The optimum cement replacement of MK and AL is 10% in the production of M40 grade concrete. The LCA (life cycle analysis) is made for the concrete specimens and the results were interpreted to know which concrete sample emits less and more carbon dioxide. These results could also help in identify the major cause for the CO2 emission and it can be used for the further research purposes..
HotSPOT: a computational tool to design targeted sequencing panels to assess early photocarcinogenesis
Authors: Grant Sydney R , Rosario Spencer R , Patentreger Andrew D , Shary Nico , Fitzgerald Megan E , Singh Prashant K , Foster Barbara A , Huss Wendy J , Wei Lei , Paragh Gyorgy 
Published: December 2022

Abstract
Mutations found in skin are acquired in specific patterns, clustering around mutation-prone genomic locations. The most mutation-prone genomic areas, mutation hotspots, first induce the growth of small cell clones in healthy skin. Mutations accumulate over time, and driver mutation clones may give rise to skin cancer. Early mutation accumulation is a crucial first step in photocarcinogenesis. Therefore, a sufficient understanding of the process may help predict disease onset and identify avenues for skin cancer prevention. Early epidermal mutation profiles are typically established using high depth targeted next-generation sequencing. However, there is currently a lack of tools for designing custom panels to capture mutation-enriched genomic regions efficiently. To address this issue, we created a computational algorithm that implements a pseudo-exhaustive approach to identify the best targeted genomic areas. We benchmarked the current algorithm in three independent mutation datasets of human epidermal samples. Compared to the sequencing panel designs originally used in these publications, the mutation capture efficacy (# of mutations/base pairs sequenced) of our designed panel improved 9.6 to 12.1-fold. Our web application hotSPOT provides a publicly available resource for researchers to design custom panels, enabling efficient detection of somatic mutations in clinically normal tissues and other similar targeted sequencing studies.
Study on the feasibility of pharmacist intervention on management of antidepressant treatment in late life depression under MDT: a mixed methods study
Authors: Wu Ju , Li Jun , Qiu Linghe , Wu Jianhong 
Published: December 2022

Abstract
OBJECTIVE: To evaluate the effect of pharmacist intervention on antidepressant treatment in late life depression under multidisciplinary team (MDT).
Method: Patients with late life depression were selected from psychological department of The Afliated Wuxi Mental Health Center of Jiangnan University from Jan. 2021 to Mar. 2022, and randomly divided into observation group and control group, with 90 cases in each group. After 3 months of follow-up, the control group was given antidepressants and routine intervention, while the observation group was treated with pharmacist intervention under MDT and the same antidepressants. The Hamilton Depression scale (HAMD), medication appropriateness index (MAI), potential inappropriate medication (PIM), adherence, quality of life and satisfaction, the incidence of adverse drug events (ADEs), number of medication regimen optimization and clinician adoption rate were observed in two groups before and after intervention.
Results: At admission, there were no statistically difference in HAMD score, total MAI scores, PIM number, adherence and quality of life between two groups (P>0.05).
After intervention, HAMD scores of both groups were significantly reduced, while MMAS-8, GQOLI-74 and GWB scores were elevated. Moreover, the differences of scores before and after interventions, both the reduction in HAMD score and the increase in MMAS-8, GQOLI-74 and GWB scores, were more significant in the observation group than in the control group. Interestingly, the total MAI score and PIM number were increased in the control group after intervention, but decreased in the observation group. With the prolongation of the treatment, the number of patients with mild to moderate depression and general to high medication adherence in two groups was increased gradually, while patients with major depression and low medication adherence were decreased gradually. Meanwhile, the observation group also showed more significant difference than the control group. Low adherence patients increased substantially at 90 days treatment in control group. There was no significant difference in the incidence of ADEs between two groups (P>0.05). The quality of life in the observation group was significantly higher than control group (P<0.05). Pharmacists put forward 164 optimization suggestions of drug regimen for the observation group, among which 109 suggestions were adopted and implemented by clinicians, with an implementation rate of 66.46%. Clinicians have a high adoption rate of pharmaceutical recommendations based on therapeutic drug monitoring (TDM), individualized genetic testing and medication methods.
Conclusion: Pharmacist intervention can improve the management of antidepressant treatment in late life depression by using HAMD, MAI, PIM and MMAS-8 as main evaluation indicators under MDT.
Architectural design strategies for enhancement of thermal and energy performance of PCMs-embedded envelope system for an office building in a typical arid Saharan climate
Authors: Sarri Abdelkader , Al-Saadi Saleh Nasser , Arıcı Müslüm , Bechki Djamel , Bouguettaia Hamza 
Published: December 2022

Abstract
The literature showed many studies that evaluated a single or multiple Phase change materials (PCMs) layers in passive, active or in hybrid configurations for building applications. However, little attention has been given to evaluate the energy performance of buildings when PCMs are used together with other passive design strategies. In this work, the energy performance of an office building in a typical arid Saharan climate is simulated using EnergyPlus when phase change materials (PCMs)-embedded envelope is implemented. The office building was analyzed without/with PCMs using various thicknesses. Results indicated that the annual electrical energy for heating, ventilation and air conditioning (HVAC) can be reduced between 3.54% and 6.18%, depending on the PCM thickness. The performance of the office building including PCMs was then simulated using two practical architectural design strategies, namely windows to wall ratio (WWR) and rezoning of the interior spaces. Outcomes revealed that the annual energy consumption for HVAC can be reduced from 10% to 15.5% and from 6.1% and 8.54% when WWR is reduced by half to three-quarters and the perimeter zones are enlarged by one-third to two-thirds of the original space area, respectively. With combining both architectural design strategies with PCM, the annual electrical HVAC energy can be reduced between 12.08% and 15.69%, depending on the design configuration and PCM thickness. This design option provides additional benefits also since it reduces the vulnerability of increasing the lighting and fuel gas heating energy because more perimeter zones are exposed to daylighting and solar radiation, respectively.
Using Oncotype DX Breast Recurrence Score® Assay to Define the Role of Neoadjuvant Endocrine Therapy in Early-Stage Hormone Receptor-Positive Breast Cancer
Authors: Taylor Caitlin , Meisel Jane , Foreman Aimee , Russell Christy , Bandyopdhyay Dipankar , Deng Xiaoyan , Floyd Lisa , Zelnak Amelia , Bear Harry , O'Regan Ruth 
Published: December 2022

Abstract
Purpose
The role of neoadjuvant endocrine therapy in the treatment of patients with early stage, hormone receptor-positive (HR+) breast cancer is not well defined. During the early part of the COVID-19 pandemic, neoadjuvant endocrine therapy was used more commonly by physicians in an attempt to delay surgery and possible exposure to COVID-19 during hospitalization; this change raised important questions surrounding the use of neoadjuvant endocrine therapy.
Methods
We assessed the rate of clinical and pathologic complete response (cCR, pCR) among a pooled cohort of patients with early stage HR + breast cancer who had been randomized to neoadjuvant endocrine therapy or neoadjuvant chemotherapy in two earlier studies to understand better how outcomes varied by Oncotype DX Breast Recurrence Score® assay.
Results
We observed that patients with intermediate RS results had no statistically significant differences in pathologic outcomes at the time of surgery based on whether they received neoadjuvant endocrine therapy or neoadjuvant chemotherapy, suggesting that a subgroup of women with a RS 0–25 may omit chemotherapy without compromising outcomes.
Conclusion
These data suggest that Recurrence Score® (RS) results may serve as a useful tool in treatment decision-making in the neoadjuvant setting.
Abnormal Wall Shear Stress Area is Correlated to Coronary Artery Bypass Graft Remodeling One Year After Surgery
Authors: Tran-Nguyen Nhien , Yan Andrew T , Fremes Stephen , Triverio Piero , Jimenez-Juan Laura 
Published: December 2022

Abstract
Coronary artery bypass graft surgery is a common intervention for coronary artery disease; however, it suffers from graft failure, and the underlying mechanisms are not fully understood. To better understand the relation between graft hemodynamics and surgical outcomes, we performed computational fluid dynamics simulations with deformable vessel walls in 10 study participants (24 bypass grafts) based on CT and 4D flow MRI one month after surgery to quantify lumen diameter, wall shear stress (WSS), and related hemodynamic measures. A second CT acquisition was performed one year after surgery to quantify lumen remodeling. Compared to venous grafts, left internal mammary artery grafts experienced lower abnormal WSS (< 1 Pa) area one month after surgery (13.8% vs. 70.1%, p = 0.001) and less inward lumen remodeling one year after surgery (-2.4% vs. -16.1%, p = 0.027). Abnormal WSS area one month post surgery correlated with percent change in graft lumen diameter one year post surgery (p = 0.030). This study shows for the first time prospectively a correlation between abnormal WSS area one month post surgery and graft lumen remodeling one year post surgery, suggesting that shear-related mechanisms may play a role in post-operative graft remodeling and might help explain differences in failure rates between arterial and venous grafts.
Association between low alanine aminotransferase levels and sarcopenia in older adults: A cross-sectional study
Authors: Luo Li , Li Jiaying , Song Jiao , Li Ying 
Published: December 2022

Abstract
Background
This study aimed to determine whether serum alanine aminotransferase (ALT) is a convenient tool to screen sarcopenia and frailty in clinical practice.
Methods
This cross-sectional and observational study included a total of 1333 residents from three communities in Chengdu, China. A bioimpedance analysis device was used to measure the appendicular skeletal muscle mass (ASM). Handgrip strength was measured with a digital handheld dynamometer. Gait speed was measured with a 6-m gait test. The sarcopenia was defined according to the Asian Working Group on Sarcopenia (AWGS) 2019. Biochemical variables including ALT were tested in the same laboratory. Other characteristics, including smoking status, alcohol drinking status, education level, and chronic comorbidities, were obtained through a face-to-face interview. We used logistic regression to evaluate the association between ALT levels and sarcopenia.
Results
Compared with the non-sarcopenia group, the sarcopenia group had a significantly lower body mass index (BMI), serum albumin levels, hemoglobin levels, calf circumference (CC), and ALT levels. Both men and women with sarcopenia or low handgrip strength had lower ALT levels than those without sarcopenia or low handgrip strength. Compared with the highest ALT quartile, the odds ratios (OR) for individuals in the lowest ALT quartile were found to be increased (OR 1.68, 95% confidence interval 1.13–2.49, P = 0.010), adjusting for age, sex, BMI, hemoglobin levels, CC, and serum albumin levels.
Conclusions
Low ALT levels were associated with sarcopenia onset involving low skeletal muscle mass and handgrip strength in older adults. ALT measurement could be used as a simple and preliminary tool to screen for frailty and sarcopenia.
Factors Affecting Conservation of Grevy’s zebra/Equus grevyi/ in Alledeghi-Assebot Proposed National Park, south eastern Ethiopia
Authors: Abirham Tolera , Bekele Afework , Yihune Mesele 
Published: December 2022

Abstract
This research was carried out in Alledeghi Assebot Proposed National Park, which is located in Afar region in the southeast of Ethiopia. Data were collected from March 2021 to April, 2022 using household survey, key informant interviews, field observation, and walking along transect line. Data were analyzed with descriptive statistics and responses rate were compared using chi-square test. 90 % of the participants were men, and 68.7% were illiterate. The average age of the respondent was 30. Habitat degradation (94.7%), disintegrated development (92.4%) and poor law enforcement (90.7%) were the major top three conservation threat for Grevy zebra and their relative threat factor severity index are 0.38, 0.378, and 0.356, respectively. There is highly significant difference among literate and illiterate respondents (𝜒2 =51.84, df=1, p= 0.00 < 0.05). Furthermore, there is significant difference between gender of the respondents (𝜒2 =21.98, df=1, p= 0.001 < 0.05). Close monitoring of Grevy’s zebra population during prolonged droughts need to be carried out by scouts and additional water provision need to be made to ensure continued access to declining water sources and avoid impact of corridor closing due to settlement. The government and other stakeholders should give attention to address the prioritized threats.
High lncCASC expression predicts poor colorectal cancer prognosis, based on an systematic review and meta-analysis
Authors: Luo Pei , Du Jie , Han Huimeng , Pan Dingguo , Cai Xin , Dong Jian 
Published: December 2022

Abstract
Background
Recent years, Growing studies have shown that long non-coding RNA CASC (lncCASC) is significantly related to the prognosis of colorectal cancer. Limited by the small number of cases in a single study and the inconsistent results various related studies, an systematic evaluation and meta-analysis was performed to explore the correlation between lncCASC expression and prognosis of colorectal cancer.
Methods
A comprehensive search of 6 relevant databases including Pubmed, Embase, Web of Science, Cochrane library, CNKI and Wanfang database was conducted. The literature was screened according to the inclusion and exclusion criteria, and the quality of the literature was evaluated using NOS score. The pool HR with 95% confidence interval (CI) were used to evaluate the correlation between lncCASC expression and OS of patients. Pool OR 95% CI was used to evaluate the effect-value such as TNM stage, lymph node metastasis and DM ect. P-value and I2 (consistency index) test were used for heterogeneity analysis. Subgroup analysis and sensitivity analysis were used to explore the sources of heterogeneity in the included literature.
Results
According to the inclusion and exclusion criteria, 8 studies with 483 patients were finally retrieved. Pooling Hazard Ratio (HR) with 95% CI showed that increasing CASC expression indicates worse overall survival (OS) (HR = 2.82, 95%CI: 1.76–4.52). The marked relationship were also uncovered between high CASC expression and advanced TNM stage (Odds Ratio (OR) = 2.38, 95%CI: 1.08–5.23), easier lymph node metastasis (OR = 2.38, 95%CI: 1.08–5.23, P = 0.0001) and easier distant metastasis (OR = 3.16, 95%CI: 1.62–6.15, P = 0.0007). In addition, the insignificant correlation or irrelevance between the expression of CASC and tumor size (OR = 1.33, 95%CI: 0.77–2.29), histological grade (OR = 0.70, 95%CI: 0.38–1.31), depth of invasion (OR = 2.74, 95%CI: 0.87–8.65), age (OR = 1.09, 95%CI: 0.71–1.68) and gender (OR = 0.97, 95%CI: 0.64–1.47) of CRC patients were also revealed. Sensitivity analysis and publication bias were performed through STATA 12.0 software, and insignificant publication bias was revealed.
Conclusion
High expression of CASC indicates a worse prognosis of colorectal cancer. LncCASC could be served as a potential prognostic indicator and a potential therapeutic target for colorectal cancer.
Subjective Social Status, Race and Metabolic Syndrome in Women with Breast Cancer
Authors: Greco Giampaolo , Bickell Nina , Lin Sylvia , Yagnik Radhi , LeRoith Derek , Gallagher Emily Jane 
Published: December 2022

Abstract
PurposeTo evaluate the association of subjective social status (SSS) with metabolic syndrome (MetS) severity and its potential contribution to racial health disparities in women with breast cancer.
Methods Multi-center cross-sectional study (10 US hospitals) in women (n=1206) with primary diagnosis of invasive breast cancer received during Mar/2013- Feb/2020. Participants, self-identified as non-Hispanic white or black, underwent physical and laboratory examinations and survey questions assessing socioeconomic parameters, medical history and behavioral risks. SSS was measured with the 10-rung McArthur scale. MetS severity was measured with a validated Z-Score. Generalized linear mixed modeling was used to analyze the associations. Missing data were handled using multiple imputation.
ResultsAverage age was 58 years. On average, the SSS of black women, given equivalent level of income and education, was lower than the SSS of white women: 6.6 (6.1 to 7.0) vs 7.7 (7.54 to 7.79) among college graduates and 6.8 (6.4 to 7.2) vs 7.6 (7.5 to 7.8) among women in the high-income category (> $75,000). In multivariable analysis, after controlling for age, income, education, diet and physical activity, increasing SSS was associated with a decrease in MetS-Z, - 0.10 (-0.16 to -0.04) per every 2 rung increase in the McArthur scale.
Conclusion Black women with breast cancer rank their SSS lower than white women with breast cancer do at each level of income and education. As SSS is strongly associated with MetS severity these results identify potentially modifiable factors that contribute to racial disparities.