bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and Facilitators of Implementing Automated Radiotherapy Planning: A Multisite Survey of Low- and Middle-Income Country Radiation Oncology Providers
Authors: McGinnis Gwendolyn J. , Ning Matthew S. , Beadle Beth M. , Joubert Nanette , Shaw William , Trauernich Christoph , Simonds Hannah , Grover Surbhi , Cardenas Carlos E. , Court Laurence E. , Smith Grace L. 
Published: May 2022

PURPOSE Global access to radiotherapy (RT) is inequitable, with obstacles to implementing modern technologies in low- and middle- income countries (LMICs). The Radiation Planning Assistant (RPA) is a web-based automated RT planning software package intended to increase accessibility of high-quality RT planning. We surveyed LMIC RT providers to identify barriers and facilitators of future RPA deployment and uptake. METHODS RT providers underwent a pilot RPA teaching session in sub-Saharan Africa (Botswana, South Africa, and Tanzania) and Central America (Guatemala). Thirty providers (30 of 33, 90.9% response rate) participated in a postsession survey. RESULTS Respondents included physicians (n = 10, 33%), physicists (n = 9, 30%), dosimetrists (n = 8, 27%), residents/registrars (n = 1, 3.3%), radiation therapists (n = 1, 3.3%), and administrators (n = 1, 3.3%). Overall, 86.7% expressed interest in RPA; more respondents expected that RPA would be usable in 2 years (80%) compared with now (60%). Anticipated barriers were lack of reliable internet (80%), potential subscription fees (60%), and need for functionality in additional disease sites (48%). Expected facilitators included decreased workload (80%), decreased planning time (72%), and ability to treat more patients (64%). Forty-four percent anticipated that RPA would help transition from 2-dimensional to 3-dimensional techniques and 48% from 3-dimensional to intensity-modulated radiation treatment. Of a maximum acceptability/feasibility score of 60, physicians (45.6, standard deviation [SD] = 7.5) and dosimetrists (44.3, SD = 9.1) had lower scores than the mean for all respondents (48.3, SD = 7.7) although variation in scores by roles was not significantly different ( P = .21). CONCLUSION These data provide an early assessment and create an initial framework to identify stakeholder needs and establish priorities to address barriers and promote facilitators of RPA deployment and uptake across global sites, as well as to tailor to needs in LMICs.
Scream Sound-induced Chronic Psychological Stress Results in Diminished Ovarian Reserve in Adult Female Rat
Authors: Xi Wenyan , Mao Hui , Cui Zhiwei , Yao Haoyan , Shi Ruiting , Gao Yane 
Published: May 2022

Abstract
It is well established that chronic psychological stress (PS) induces female reproductive dysfunction. However, the studies on the consequences of chronic PS exposure precisely targeting ovarian reserve are lacking. In the present study, we employed a chronic scream sound-induced PS model to investigate the potential effect of pure psychosocial stressors on ovary reserve. Female rats were subjected to scream sound stress, white noise, or background for 3 weeks. Animals were euthanized by cervical dislocation after stress for collection of blood or ovaries. Sex hormones were analyzed by enzyme-linked immunosorbent assay. The follicle number was examined by histopathology. Granulosa cell apoptosis of the ovaries was examined by in situ cell death detection kit. Finally, rats were mated with proven fertile male rats to study fertility parameters. Female rats exposed to scream sound were presented with reduced weight gain and sucrose preference, while immobility time in forced swim test and serum corticosterone concentration were significantly increased. Scream sound stress sequentially decreased plasma anti-Müllerian hormone and estradiol concentration, induced primordial and preantral follicles loss, augmented granulosa cell apoptosis in ovarian growing follicles, and eventually decreased litter sizes. Based on these results, we suggest that chronic PS induced loss of ovarian reserve by accelerated primordial follicle activation and destruction of growing follicles, which results in follicle depletion and decreased fertility.
Papillary Thyroid Cancer and a TERT Promotor Mutation-positive Paraganglioma in a Patient With a Germline SDHB Mutation
Authors: Alzahrani Ali S , Alswailem Meshael , Murugan Avaniyapuram Kannan , Alghamdi Balgees , Al-Hindi Hindi 
Published: May 2022

Abstract

Purpose
About 40% of paragangliomas (PGL) are due to germline mutations in one of several susceptibility genes. These genes rarely predispose to other non-PGL tumors. Here, we describe and functionally characterize a germline SDHB mutation in a patient who developed a BRAFV600E mutation-positive papillary thyroid cancer (PTC) and a TERT promotor mutation-positive PGL.

Experimental design
A 28-year-old asymptomatic man was discovered incidentally to have a large left-sided mid-abdominal PGL and PTC. He underwent resection of the PGL and total thyroidectomy and neck dissection followed by I-131 adjuvant therapy for PTC. The histopathology revealed a high-grade PGL and a tall cell-variant PTC with lymph node metastases (T1b N1b M0). He soon developed PGL spinal metastases that have been rapidly progressing and is currently being treated with Lu177-dotatate therapy. Family screening revealed a positive SDHB mutation in the mother, a son, and a brother.

Results
In addition to the heterozygous SDHB germline mutation (c.688C&gt;T, p.Arg230Cys), molecular analysis revealed a somatic TERT promotor mutation (C228T) in PGL (negative in PTC) and a somatic BRAFV600E mutation in PTC (negative in PGL). Functional studies showed a higher proliferation rate in the mutant compared with the wild-type SDHB.

Conclusion
Germline SDHB mutations rarely occur in patients with PTC and may contribute to its aggressiveness. Somatic TERT promotor mutations rarely occur in PGL and contribute to its aggressiveness and metastatic potential.
The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity
Authors: Smit Marlinde J. , Martini Tosca E. I. , Armandari Inna , Bočkaj Irena , Zomerman Walderik W. , de Camargo Magalhães Eduardo S. , Siragna Zillah , Meeuwsen Tiny G. J. , Scherpen Frank J. G. , Schoots Mirthe H. , Ritsema Martha , den Dunnen Wilfred F. A. , Hoving Eelco W. , Paridaen Judith T. M. L. , de Haan Gerald , Guryev Victor , Bruggeman Sophia W. M. 
Published: May 2022

ABSTRACT
Sonic hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) lineage, which depends on Hedgehog signaling for its perinatal expansion. Whereas SHH tumors exhibit overall deregulation of this pathway, they also show patient age-specific aberrations. To investigate whether the developmental stage of the CGNP can account for these age-specific lesions, we analyzed developing murine CGNP transcriptomes and observed highly dynamic gene expression as a function of age. Cross-species comparison with human SHH medulloblastoma showed partial maintenance of these expression patterns, and highlighted low primary cilium expression as hallmark of infant medulloblastoma and early embryonic CGNPs. This coincided with reduced responsiveness to upstream SHH pathway component Smoothened, whereas sensitivity to downstream components SUFU and GLI family proteins was retained. Together, these findings can explain the preference for SUFU mutations in infant medulloblastoma and suggest that drugs targeting the downstream SHH pathway will be most appropriate for infant patients.
Low Threshold Amplified Spontaneous Emission from Multicolor-Tunable E,E-1,4-Bis(2-trifluoromethylstyryl)benzene Crystals
Authors: Mochizuki Hiroyuki 
Published: May 2022

Abstract
E,E-1,4-bis(2-trifluoromethylstyryl)benzene (2CF3) can form two types of crystals—one emitting purple-blue (vF-2CF3) and the other emitting green (gF-2CF3)—by simply drop-casting its solution onto polydimethylpolysiloxane. Subjecting vF-2CF3 to a N2 laser excitation causes it to exhibit amplified spontaneous emission with a low threshold of 6.8 µJ cm−2.
Pattern changes of cutaneous dermatoses among Iraqi women preceding and during the COVID-19 pandemic
Authors: A. Abdullah Galawish 
Published: May 2022

Background: We compared the pattern of cutaneous dermatoses among Iraqi females of all ages between 4 months preceding the coronavirus disease 2019 (COVID-19) pandemic, and the same months 1 year later within the COVID-19 pandemic. Methods: This was a cross-sectional study, that targeted all female patients attending an outpatient clinic for dermatology and venereology in Al-Kindy teaching hospital, Baghdad between October 2019 to the end of January 2020, and the same 4-month duration 1 year later (October 2020 to the end of January 2021) after the COVID-19 peak period had passed and there was no or partial curfew to exclude seasonal impact. Results: A total of 2657 female-patients of all ages were enrolled in this study with 1314 females during the 4 months pre COVID-19, and 1343 females during the pandemic. The mean age of patients presented before the pandemic was 27.2±16.6 years, while the mean age of patients during the pandemic was 28.1±15.6 years with no statistically significant difference in mean ages (P >0.05). Hair loss in general with telogen effluvium specifically increased significantly. Cutaneous contagious viral infections were reduced significantly and specifically of these molluscum contagiosum and condylomata accuminata. Other forms of infections including bacterial and parasitic were also reduced while dermatophytosis was increased but not to a significant level. Acne vulgaris, rosacea, lichen planus, urticaria, pityriasis rosea, seborrheic dermatitis, and vitiligo were increased, but psoriasis, alopecia areata, other types of dermatitis, and melasma were reduced but none to a significant level. Conclusions: The COVID-19 pandemic resulted in changes in the pattern of diseases presented to an out-patient clinic for dermatology and venereology. This could be either related to COVID-19 infection or stress associated with the pandemic, because of curfew, or wearing facemasks which may cause a decrease or increase in certain diseases.
What and how do different stakeholders contribute to intervention development? A mixed methods study.
Authors: Racine Emmy , O Mahony Lauren , Riordan Fiona , Flynn Gráinne , Kearney Patricia M. , McHugh Sheena M. 
Published: May 2022

Background: UK Medical Research Council guidelines recommend end-user involvement in intervention development. There is limited evidence on the contributions of different end-users to this process. The aim of this Study Within A Trial (SWAT) was to identify and compare contributions from two groups of end-users - people with diabetes’ (PWD) and healthcare professionals’ (HCPs), during consensus meetings to inform an intervention to improve retinopathy screening uptake. Methods: A mixed method, explanatory sequential design comprising a survey and three semi-structured consensus meetings was used. PWD were randomly assigned to a diabetes only or combined meeting. HCPs attended a HCP only or combined meeting, based on availability. In the survey, participants rated intervention proposals on acceptability and feasibility. Survey results informed the meeting topic guide. Transcripts were analysed deductively to compare feedback on intervention proposals, suggestions for new content, and contributions to the final intervention. Results: Overall, 13 PWD and 17 HCPs completed the survey, and 16 PWD and 15 HCPs attended meetings. For 31 of the 39 intervention proposals in the survey, there were differences (≥10%) between the proportion of HCPs and PWD who rated proposals as acceptable and/or feasible. End-user groups shared and unique concerns about proposals; both were concerned about informing but not scaring people when communicating risk, while concerns about resources were mostly unique to HCPs and concerns about privacy were mostly unique to PWD. Fewer suggestions for new intervention content from the combined meeting were integrated into the final intervention as they were not feasible for implementation in general practice. Participants contributed four new behaviour change techniques not present in the original proposals: goal setting (outcome), restructuring the physical environment, material incentive (behaviour) and punishment. Conclusions: Preferences for intervention content may differ across end-user groups, with feedback varying depending on whether end-users are involved simultaneously or separately.
What influences a person’s willingness to share health information for both direct care and uses beyond direct care? Findings from a focus group study in Ireland
Authors: Flaherty Sarah Jane , Duggan Catherine , O'Connor Laura , Foley Barbara , Flynn Rachel 
Published: May 2022

Background: The sharing of health information is invaluable for direct care provision and reasons beyond direct care, such as for health services management. Previous studies have shown that willingness to share health information is influenced by an individual’s trust in a healthcare professional or organisation, privacy and security concerns, and fear of discrimination based on sensitive information. The importance of engaging the public in policy and practice development relating to the use and sharing of health information has been identified as an essential step for countries to take. This study’s aim was to examine the factors that influence the Irish public’s willingness to share their health information as part of a national public engagement on health information. Methods: A qualitative study using online focus groups was conducted as part of a wider national public engagement on health information. Participants were purposively recruited from a combination of public, patient, and service user groups in Ireland. Focus group interviews were audio-recorded, transcribed verbatim and analysed using inductive content analysis. Results: In total, 85 participants took part in 14 focus groups between January and March 2021. Two major themes were identified, trust and personal and public benefits of sharing health information. The ability to exercise control over personal information, perceived transparency of the process, and the extent to which the healthcare service was viewed as confidential, all influenced the level of trust a person held. Perceived benefits were influenced by the extent to which participants believed information sharing would support improved care or provide broader public benefit, and balanced against the potential for personal harm. Conclusions: The findings allow for new insights into the views of the public on the use and sharing of personal health information and can be used to inform the development of a consent model for health information.
Adapting a first- and second-year medical student psychiatric interview course for virtual learning
Authors: Curry Ashley , Butterfield Austin , Kunkle Leigh , Sakai Joseph 
Published: May 2022

Background: In response to the COVID-19 pandemic, a first- and second-year psychiatric interviewing course was converted to a virtual platform with interviews performed via video conferencing. Telepsychiatry has been shown to be an effective modality for patient care, but little is known about the effectiveness of using this modality to teach the psychiatric interview. We sought to examine how switching to remote learning would affect the quality of the course. Methods: We compared student course evaluations from 2019 (in-person) with evaluations from the 2020 (virtual). Using Likert scales, students were asked to rate their comfort in interviewing patients, discussing emotional and psychological topics, and documenting the encounter. Student responses were supplemented with qualitative feedback and input from faculty facilitators. Results: We found no significant difference in student reports of their overall experience with the course, comfort with interviewing patients or with discussing emotional and psychological issues. The course reduced student self-reported stigma toward mental illness. Conclusions: The virtual delivery of this course offers learners a very similar experience to an in-person course. Looking beyond the pandemic, this model could have applications in other institutions where geographic or other logistical considerations would impede the implementation of such a course in-person.
Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia
Authors: Navapurkar Vilas , Bartholdson Scott Josefin , Maes Mailis , Hellyer Thomas P , Higginson Ellen , Forrest Sally , Pereira-Dias Joana , Parmar Surendra , Heasman-Hunt Emma , Polgarova Petra , Brown Joanne , Titti Lissamma , Smith William PW , Scott Jonathan , Rostron Anthony , Routledge Matthew , Sapsford David , Török M. Estée , McMullan Ronan , Enoch David A , Wong Vanessa ,   VAP-Rapid investigators, Curran Martin D , Brown Nicholas M , Simpson A John , Herre Jurgen , Dougan Gordon , Conway Morris Andrew 
Published: May 2022

Background: The diagnosis of pneumonia has been hampered by a reliance on bacterial cultures which take several days to return a result, and are frequently negative. In critically ill patients this leads to the use of empiric, broad-spectrum antimicrobials and compromises good antimicrobial stewardship. The objective of this study was to establish the performance of a syndromic molecular diagnostic approach, using a custom TaqMan array card (TAC) covering 52 respiratory pathogens, and assess its impact on antimicrobial prescribing. Methods: The TAC was validated against a retrospective multi-centre cohort of broncho-alveolar lavage samples. The TAC was assessed prospectively in patients undergoing investigation for suspected pneumonia, with a comparator cohort formed of patients investigated when the TAC laboratory team were unavailable. Co-primary outcomes were sensitivity compared to conventional microbiology and, for the prospective study, time to result. Metagenomic sequencing was performed to validate findings in prospective samples. Antibiotic free days (AFD) were compared between the study cohort and comparator group. Results: 128 stored samples were tested, with sensitivity of 97% (95% confidence interval (CI) 88-100%). Prospectively, 95 patients were tested by TAC, with 71 forming the comparator group. TAC returned results 51 hours (interquartile range 41-69 hours) faster than culture and with sensitivity of 92% (95% CI 83-98%) compared to conventional microbiology. 94% of organisms identified by sequencing were detected by TAC. There was a significant difference in the distribution of AFDs with more AFDs in the TAC group (p=0.02). TAC group were more likely to experience antimicrobial de-escalation (odds ratio 2.9 (95%1.5-5.5)). Conclusions: Implementation of a syndromic molecular diagnostic approach to pneumonia led to faster results, with high sensitivity and impact on antibiotic prescribing.
Visual and Verbal Means to Attract our Clicks: Multimodality in Youtube Thumbnails
Authors: Riyandi Shierlynda Winnindya 
Published: May 2022

Pictures, color, tones, and motions have all been identified as modalities that help to create the meaning-making process. A multimodal message is made up as two or more modes work together to give meaning for the overall discourse. This article is to describe how the visual and verbal signs work together in constructing meaning in video thumbnails. This study is used as a descriptive research method. The data are thumbnails of the most-viewed videos in Close the Door podcast. They were analyzed by employing Kress& van Leeuwen's Visual Grammar and Halliday’s Functional Grammar of language, especially ideational meaning of clause, transitivity. These are to explain the relationships between the images and the texts and elucidates the functions of images in meaning interpretation. Based on the analysis, all the thumbnails evoke a clear message video; they have no ambiguity and are in line with content of the video. Amongst 4 data, there are four types used; relational, mental, material, verbal with descriptive sentences by three data and one imperative. In terms of MDA Visual, the videos have Lead, Display and Emblems as the relationships between the images and the functions of images in meaning interpretation.
Photonics-assisted joint communication-radar system based on a QPSK-sliced linearly frequency-modulated signal
Authors: Wang Shi , Liang Dingding , Chen Yang 
Published: May 2022

A photonics-assisted joint communication-radar system is proposed by introducing a quadrature phase-shift keying (QPSK)-sliced linearly frequency-modulated (LFM) signal. An LFM signal is carrier-suppressed single-sideband modulated onto the optical carrier in one dual-parallel Mach–Zehnder modulator (DPMZM) of a dual-polarization dual-parallel Mach–Zehnder modulator (DPol-DPMZM). The other DPMZM is biased as an IQ modulator to implement QPSK modulation on the optical carrier. The polarization orthogonal optical signals from the DPol-DPMZM are further combined and detected in a photodetector to generate the QPSK-sliced LFM signal. The QPSK-sliced LFM signal is used to realize efficient data transmission and high-performance radar functions including ranging and imaging. An experiment is performed. Radar range detection with an error of less than 4 cm, inverse synthetic aperture radar imaging with a resolution of

14.99

c
m

×

3.25

c
m

, and communication with a data rate of 105.26 or 210.52 Mbit/s are successfully verified.