bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of Adaptive Saanen Goat Milk Production and Reproduction Fed Diet Supplemented with Indigofera zollingeriana Leaf Meal
Authors: Fikar Samsul , Suhartati Fransisca Maria , Bata Muhamad 
Published: October 2022

The objective of this research was to examine the effect of the addition of Indigofera zollingeriana leaf meal (IZLM) in diets on milk production and fermentation products of adaptive Saanen goat. The research was conducted at Balai Besar Pembibitan Ternak Unggul dan Hijauan Pakan Ternak (BBPTUHPT) or or the Center for Superior Animal Breeding and Forage Animal Feed, Baturraden, Central Java. A total of 18 first lactating adaptive Saanen goats with a body weight of 34.83±7.13 and aged 20-24 months were used in this study. The goats were kept in individual pens and grouped into 6 groups based on body weight and each group were randomized to receive three kinds of concentrate substitution with IZLM of 0%, 10% and 20 % of dry matter (DM) concentrates, for A, B and C treatments, respectively. Therefore, this research was designed according to randomized block design. Dry matter intake (DMI) of each goat was 4.5% of live weight with dry matter (DM) ratio of forage and concentrate were 60:40. The variables measured were DMI, partial volatile fatty acid (VFA), energy conversion efficiency of glucose into VFA (ECEVFA), methane gas, total protozoa, milk production and the first estrus after kidding. Analysis of variance showed that the treatment had a significant effect (P <0.05) on propionate, milk production and fat, but no significant effect (P> 0.05) on consumption of DM, acetate, butyrate, EKVFA, methane gas, lactose and protein milk. Increasing the IZLM substitution level enhanced linearly (P<0.05) on production of milk and milk fat, while the propionate concentrate responded to quadratic (P<0.05). Milk production increased at IZLM level of 20%, while goat in this group resulted only 16.70% estrous after birth compared to goat group received 10% IZLM level resulting 50% of estrus goat. The results of this study concluded that the recommended level of using IZLM as a concentrate substitute was only 10%.
Differences in Cancer Screening Responses to State Medicaid Expansions by Race and Ethnicity, 2011‒2019
Authors: Friedman Abigail S. , Thomas Sasha , Suttiratana Sakinah C. 
Published: October 2022

Objectives. To estimate whether state Medicaid expansions’ relationships to breast, cervical, and colorectal cancer screening differ by race/ethnicity.Methods. Analyses conducted in 2021 used 2011–2016 and 2018–2019 Behavioral Risk Factor Surveillance System data on adults aged 40 to 64 years with household incomes below 400% of the federal poverty guideline (FPG; n = 537 250). Triple-difference analyses compared cancer screening in Medicaid expansion versus nonexpansion states, before versus after expansion, among people with incomes above versus below the eligibility cutoff (138% FPG). Race/ethnicity and ethnicity-by-language interaction terms tested for effect modification.Results. Associations between Medicaid expansions and cancer screening were significant for past-2-year mammograms and past-5-year colorectal screening. Effect modification analyses showed elevated mammography among non-Hispanic Asian women (+9.0 percentage points; 95% confidence interval [CI] = 3.2, 14.8) and Hispanic women (+6.0 percentage points; 95% CI = 2.0, 10.1), and Papanicolaou tests among Hispanic women (+4.2 percentage points; 95% CI = 0.1, 8.2). Findings were not limited to English- or Spanish-speaking respondents and were robust to insurance status controls.Conclusions. Medicaid expansions yielded statistically significant increases in income-eligible Asian and Hispanic women’s mammography and Hispanic women’s Pap testing relative to non-Hispanic White women. Neither language proficiency nor insurance status explained these findings. (Am J Public Health. 2022;112(11):1630–1639. https://doi.org/10.2105/AJPH.2022.307027 )
Multiscale Pore Structure Evolution of Longmaxi Shale Induced by Acid Treatment
Authors: Xu Sai , Zhou Shangwen , Zhou Junping , Wang Lei , Sheng Mao , Cai Jianchao 
Published: October 2022

SummaryHydraulic fracturing to generate complex fracture networks is essential for shale reservoir development. However, the recovery of shale oil and gas is still low due to various engineering and geological factors. Acid treatment has been approved as a potential approach to enhance stimulated reservoir volume (SRV) by changing petrophysical and mechanical properties. Understanding the multiscale pore structure evolution behind the macro-performance change is critical in the application of acid treatment in shale reservoirs. In this study, cylindrical and powder shale samples from the Longmaxi formation are treated with 15 wt% hydrochloric acid (HCl) for 10 days. Before and after acid treatment, X-ray computed tomography (CT) and N2 adsorption techniques are used to characterize shale pore structure at microscale and nanoscale, respectively. Combined with the determination of variations in chemical compositions of shale samples and acid solutions, the mechanism of multiscale pore structure evolution induced by acid treatment is discussed. The N2 adsorption results uncover a considerable increase in volume and size of nanopores. All the nanopores increase in carbonate-rich shale, whereas the micropores and mesopores undergo a decrease in clay-rich shale. Reconstructed 3D CT images reveal the generation of large volumes of microscale pores and fractures, which leads to an increase in porosity of about 9%. The pore structure evolution in shale due to acid treatment is controlled by both mineralogy and microstructure. These findings demonstrate the promise of acid treatment for enhanced SRV and long-term productivity of shale oil and gas reservoirs in China.
Prevalence and correlates of depression and anxiety in patients with functional anorectal pain
Authors: Dong Liping , Sun Ting , Tong Ping , Guo jia , Ke Xiaoyan 
Published: October 2022

Abstract
Purpose Patients with functional anorectal pain (FAP) often experience psychological distress, impaired quality of life, increased healthcare utilisation, and even suicidal tendencies. However, limited data exists on the psychological correlates of FAP in Chinese patients. Therefore, this study aimed to examine the prevalence of depression, anxiety, and related psychosocial factors in Chinese patients with FAP.
Methods We used a cross-sectional research design and recruited 100 patients with FAP from SuBei Hospital’s multidisciplinary clinic for pelvic floor disorders between January and December 2021. Information on patients’ demographic and disease characteristics was also collected. Depressive and anxiety symptoms were assessed using the Patient Health Questionnaire Depression (PHQ-9) and the Generalised Anxiety Disorder Questionnaire (GAD-7). Multiple logistic regression analysis was used to examine factors associated with depression and anxiety.
Results The prevalence of depressive and anxiety symptoms among patients with FAP was 55 % and 46 %, respectively. Being a woman, specific marital status (single, divorced, separated, or widowed), longer FAP duration, and sleep disturbance were significantly associated with an increased risk of depressive symptoms. Additionally, specific marital status (single, divorced, separated, or widowed), sleep disturbance, and high Visual Analogue Scale scores were associated with anxiety symptoms.
Conclusions Depressive and anxiety symptoms are prevalent in patients with FAP. Several socio-demographic and clinical predictors have been identified. There is a need for psychologists to be involved in the treatment of patients with FAP. Thus, multidisciplinary treatment may be the optimal treatment strategy.
A Prototype For Quantum Database In
Hybrid Quantum
Authors: Chakraborty Sayantan 
Published: October 2022

Abstract
This study proposes a prototypeAnd a possibility to converge both this quantum database and classical database. This report mostly identifies the gap between this classical database and quantum database but it shows no result rather it proposes only the hypothesis and prototype which can be implemented in future products. It is a way that can be used in future industrial product development on hybrid quantum computers. The existing concept used to consider oracle as a black box this study opens up the possibility for the quantum industry to develop the QASAM module so that we can develop a fully quantum database instead of using a classical database as BlackBox. So we will propose a logical design for memory management for the quantum database , security enhancement model automatic storage management model for quantum database.
Lumpy Skin Disease Emerging Problem in Pakistan
Authors: Imran Muhammad , Hashmi Asraf Hussain , Khalique Faisal , Iqbal Muhammad Zahid 
Published: October 2022

Abstract
Lumpy skin disease is important disease of livestock sector posing a big problem to livestock sector and economy. The virus belongs to the Capripoxvirus genus of the family Poxviridae, which also contains sheep pox virus and goat pox virus. LSD is enzootic in several African countries. Since 2012, the disease has spread rapidly and widely throughout the eastern Europe regions, southern Caucasus and parts of the Russian Federation as well as parts of Asia. It is one of the most serious health issues confronting the global cattle business. In addition to the international trade embargo and animal movement restrictions, the disease causes major economic losses owing to skin damage, reduced meat and milk production, infertility, mastitis, and mortality. Lumpy skin disease spread more rapidly in Province Sindh and some parts of province Punjab. Since March 2022, verifiable epidemiological data has revealed a 33% morbidity rate and a 0.6% mortality rate in Pakistan. The southern Punjab cattles were more affected with lumpy skin diseases as compared to northern Punjab. Mortality and infection rate of lumpy skin disease become double during Eid al Adha. The first LSD outbreak was detected in southern Pakistan in November 2021 and notified by the government on March 4th, 2022. Since 2019, LSD has been detected in India, China, and Iran, all of which share Pakistan's border possibly indicating a transboundary transmission channel from Iran and India, both of which border southern Pakistan. LSD is unquestionably posing a danger to dent Pakistan's livestock sector and business.
Monitoring of Harmful Algal Bloom (HAB) of Noctiluca scintillans (Macartney) along the Gulf of Mannar, India using in-situ and satellite observations and its impact on wild and maricultured finfishes
Authors: Rameshkumar Palsamy , Thirumalaiselvan Shanmugam , Raman Mini , Remya Lalitha , Jayakumar Rengarajan , Sakthivel Mohammed , Tamilmani Govindan , Sankar Murugesan , Anikuttan Kuravamparambu Kuttan , Menon Nandini Menon , Saravanan Raju , Ravikumar Thimmakkondu Thiyagarajan , Narasimapallavan Gunasekaran Iyyapparaja , Krishnaveni Nataraj , Muniasamy Velliyan , Batcha Sikkander Mohammed , Gopalakrishnan Achamveetil 
Published: October 2022

Abstract
Three incidences of bloom (Noctiluca scintillans) has been recorded in Gulf of Mannar (GOM) during 2019(September) 2020(September& October) and 2021 (October). On 10th September 2019, a deep green bloom started along the coast of Gulf of Mannar stretching from Kunthukkal(9.2579° N, 79.2213° E) to Vedalai (9.2723° N, 79.1040° E) (about 10 kms) and algal crashing started on 11th and 12th September, 2019, resulting in mass mortality of about twenty wild fish groups mostly associated with coral reefs. The ichthyo-diversity affected during the bloom period have been identified and quantified. Noctiluca cell density was high ranging from 1.33 x 103cells/L to 1.24 x106cells /L with slight year to year variations. High chlorophyll concentrations (> 7.5 mg /m3) were measured during the bloom event at the cage site. Remote sensing images acquired from MODIS –Aqua 4 km data during the bloom period indicates very high concentration of chlorophyll in most of the northern areas of GOM indicating the presence of algal bloom. Low concentration of dissolved oxygen (less than 3.5 mg/L) was measured during the bloom in all the three years. Concentration of ammonia in surface and sea bottom waters was quite high 7.54 & 18.86µg-at/L. Wild fishes in the coral reefs and fishes cultured in cages (Cobia and Silver Pompano), were found dead due to acute hypoxia and anoxia. Decay of the bloom led to enormous ammonia production, sudden reduction of dissolved oxygen in the water and, eventually stress, shock and mortality of all fishes.
Ectopic Pregnancy in China during 2011-2020: A Single-Centre Retrospective Study of 9499 Cases
Authors: Xu Haihua , Lin Guan , Xue Lifang , Wu Weifang , Ding Jinlian , Liu Chaobin 
Published: October 2022

Abstract
Background: Previous studies have shown that the incidence of ectopic pregnancy (EP) is increasing in China. It is unclear, however, whether the incidence of EP has changed after the implementation of the universal two-child policy in the context of China's aging population and declining fertility rate.
Methods: Data with respect to EP were collected from the hospital's electronic medical records from January 2011 to December 2020, which included the annual number of delivery, cesarean section rate and ectopic pregnancies, treatment of tubal pregnancy, and averaged costs and length of stay in the hospital. Trends were analyzed and annual percentage change (APC) was calculated using connected point regression analyzes.
Results: A total of 9499 cases of EP were collected, among which cesarean scar pregnancy (CSP) account for the second most (6.73%). The EP per 100 deliveries revealed a downward trend, from 7.60% in 2011 to 4.28% in 2020 with an APC of -1.87 (P < 0.05). The maternal age was increased, especially after the implementation of the universal two-child policy. Constituent ratio for the advanced maternal age (≥ 35) and the cesarean section rate, but not the CSP, were also increased. Laparoscopic salpingectomy was the main surgical method, whereas the adoption of laparotomy and laparoscopic salpingostomy was decreasing year by year.
Conclusions: Although the implementation of the universal two-child policy increased the number of births, the proportion of older mothers and cesarean section rate, this policy change seems to be less effective on EP.
Identification of a novel pyroptosis related long noncoding RNA subtypes, development of a prognostic model and characteristics of the tumor microenvironment in gastric cancer
Authors: Qi Yong , Cao Pengwei , Wang Haibo , Wu Wenyong , Cao Feng 
Published: October 2022

Abstract
Background Pyroptosis-related long noncoding RNAs (lncRNAs) (PRLs) are closely related to gastric cancer (GC). However, However, the mechanism of its role in GC has not been elaborated. This study deeply analyzed the potential role of PRL in GC.
Methods A PRLs coexpression network was constructed via GC data from the TCGA dataset. Cox analysis was used to determine the prognosis related PRLs. QRT–PCR was used for quantitative verification. LASSO analysis and multivariate Cox analysis were used to construct the prognosis model of PRLs and calculate the risk score of each sample. The clinical characteristics, prognosis and tumor microenvironment (TME) of different risk groups were analyzed. Finally, we constructed a ceRNA network of lncRNA miRNA/mRNA and five histone modification modes (H3K27ac, H3K4me1, H3K17me3, H3K4me3, and H3K9me3).
Results We obtained seven PRLs and constructed a prognostic model. In addition, we also drew a highly accurate nomogram to predict the prognosis of GC. The expression of lncRNAs AP000695.1 and AC087301.1 was significantly different between GC tissues and normal tissues. The immune function and TME also changed in different risk groups. We found the sub-networks of miRNAs and target genes related to AP000695.1 and AC243964.3. And we also found that the AC007277.1 enhancer region H3K27ac, H3K4me1, H3K4me3 levels increased.
Conclusion This study revealed the clinical features, prognosis and tumor microenvironment of PRL in gastric cancer, and further explored its potential role in GC. This study revealed the clinical characteristics, prognosis and tumor microenvironment of PRLs in GC. The potential role in GC was discussed, which provided a new theoretical basis and ideas for immunotherapy of GC.
Qualitative Study on Needs of Children in Schools for Special Needs among the Teachers in North Central Nigeria
Authors: Alatishe-Muhammad Bilqis Wuraola , Olubiyi Olubunmi Abiola , Afolayan Munirat Ayoola , Adeyemi Omorola Motunrayo , Ameen Hafsat Abolore , Bolarinwa Oladimeji Akeem , Salaudeen Ganiyu Adekunle , Olubiyi Olufemi Mubo 
Published: October 2022

Abstract
Background: For a long time, the assumption has been that the children found in the classroom all have the same needs including their health needs. However, experience has shown that each child comes from different home background and some may have some special needs to be given special attention. The schools for special needs are specifically designed, resourced and staffed to cater for children with learning difficulties, physical disabilities and intellectual problems. This study assessed the needs of children in schools for special needs among teachers.
Methods: This cross-sectional study was carried out in three schools of special needs in north-central states of Nigeria. A total number of forty-two (42) teachers were involved in six sessions of the FGD with seven respondents in each session. The observational checklist was used by the researcher to observe facilities availability and functionality in meeting the needs of the children. Data collected was analyzed using thematic analysis.
Results: All the schools had teachers and non-teaching staff comprising of those with/without disability. They all have clinic but only one school is well-equipped. Though they all have health records system in place, but they are not cumulative. The five schools had pipe borne water source, but they practiced open dumping and burning of refuse.
Conclusion:
The students have over the years adapted to their impairment and it doesn’t affect their learning in any way and that the students in schools for special needs have peculiarities and these are understood by the teachers for appropriate teaching of each student.
A prospective randomized study comparing 27-Gauge Vitrectomy to 23-Gauge Vitrectomy for epiretinal membranes and full thickness macular holes.
Authors: Caretti Luigi , Pillon Giulia , Verzola Giacomo , Monterosso Cristina , Formisano Martina 
Published: October 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
One-Step Combinatorial Strategy for Optimization of Antibiotics With Plant Extract Against Drug Resistant Clinical Bacteria
Authors: Gideon Mathew , Ladan Zakari 
Published: October 2022

Abstract

Antimicrobial resistance (AMR) is of global concern, resistance to every antibiotic is not a basic requirement for a bacteria or fungi to be considered dangerous, serious problem can arise by resistance to just one antibiotic. Medicinal plants are major sources of active ingredients in prescription drugs. This current work demonstrate a one-step combinatorial strategy were antibiotics can be optimize using random selectivity of phytochemicals present in aqueous plant extract to be effective against resistant clinical isolates of Streptococcus spp, Salmonella spp, Staphylococcus aureus, Shigella spp and Escherichia coli. Concentrated sulphuric acid and 10% sodium hydroxide were used in combinatorial synthesis of Calotropis procera extract with Amoxicillin and Ampicillin at 1 mg/mL. To validate the positive results obtain in stage one, Piliostigma reticulatum extract were combined with 100 µg/mL of azithromycin and separately with 100 µg/ml of ampicillin varying the volume of the acid. Higher inhibitions zone were observed at 16.7 mm for salmonella spp, 16.4 mm shigella spp, 16.8 mm S. aureus, 21.3 mm E.coli and 22.4 mm streptococus at situations where antibiotics inhibitions zones were 0 mm. The results of this present work proposed a cost effective methods which antibiotics can be enhance to overcome resistance in bacteria using various phytochemicals present in plant extracts, this methods can be explore and applied in different ways to identify novel compounds, isolates and purify their active principles for selectivity, efficacy, safety and their development to clinical trial candidate, it may also be applied in antiviral and anticancer research to overcome enormous scientific challenges.
Study on the Rotation Method for Correcting the Depth of the Kidney to Optimize Renal Dynamic Imaging
Authors: Wei Hua , Han Ke , Wu Jiaojiao , Hu Guang , Wu Zhifang , Wang Hongliang , Guo Xiaoshan , Hou Yansong , Wang Rui , Li Sijin 
Published: October 2022

Abstract
Purpose: We aimed to investigate the effect and significance of the rotation method corrected for the depth of two kidneys on the determination of glomerular filtration rate (GFR) in total and single kidneys by the renal dynamic imaging Gates method.
Methods: Seventy-two patients who underwent dynamic renal imaging by the rotation method and abdominal CT in our hospital were collected in the present study. CT scanning, rotation method, Tonnesen's formula, and Li-Qian's formula were compared in terms of the depth of two kidneys, depth difference between the two kidneys, and the total renal and single GFR obtained by substituting the renal depth values into Gates' formula.
Results: ①GFR and the depth of kidneys: Compared to CT, Tonnesen's formula significantly underestimated the total and single renal GFR and the depth of both kidneys (P < 0.05). No significant differences were found in the total and single renal GFR and the depth of both kidneys between Li-Qian's formula and the rotation method (P > 0.05), with a strong agreement and with the least bias in the values measured by the rotation method. ②Renal depth difference: Compared to CT, Tonnesen's formula and Li-Qian's formula underestimated the difference in depth between the two kidneys (P < 0.05). None of the differences were statistically significant based on the rotation method (P > 0.05). The depth difference was positively correlated with the resulting changes in single renal function (|R(CT)-R(Li-Qian)|) and (|R(rotation)-R(Li-Qian)|) (r = 0.881, 0.641, P < 0.001). As the depth difference increased, Li Qian's formula could not visualize changes in single renal function accurately. In contrast, the accuracy of the rotation method in assessing single renal function remains unaffected.
Conclusion: The rotation method obtains an accurate depth and depth difference between the two kidneys without additional CT radiation, enhancing the accuracy of the Gates method for determining total and single renal GFR.
Trial registration: Medical Ethics Committee of First Hospital of Shanxi Medical University, 2021BAL0146. Registered 12 January 2021.