bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of psychoeducation in the treatment of eating disorders: Protocol for a systematic review
Authors: Mesarič Katja Kurnik , Damjanac Žiga , Debeljak Tjaš , Kodrič Jana 
Published: November 2022

Abstract
Background: Eating disorders in childhood and adolescence negatively affect many areas of development and functioning.
Methods: We designed and registered a study protocol for a systematic review of studies examining the effectiveness and contribution of psychoeducational interventions in the treatment of eating disorders in children and adolescents. Studies will be identified through a literature search of the PubMed, PsycINFO, and Web of Science electronic databases. Two independent reviewers will screen the papers. Data will be presented in a table with an accompanying narrative summary to answer the review question.
Discussion: This systematic review is the first to systematically examine psychoeducational interventions in the treatment of eating disorders. Our findings are of potential interest to clinicians working with children and adolescents, and parents of children with eating disorders.
Systematic review registration: The protocol has been registered at the international Prospective Register of Systematic Reviews (PROSPERO). The registration number is CRD42022358432.
Mapping Knowledge Structure and Themes Trends of Trace elements and Chronic Kidney Disease: A Bibliometric Analysis
Authors: Yang Yaqin , Zhang Duo , Lin Yujie , Wu Yuchi , Huang Xinyan 
Published: November 2022

Abstract
Objective: This study aimed at providing an overview of the current state and the emerging role of trace elements in chronic kidney disease (CKD) using a bibliometric approach.
Methods: Scientific literature on CKD published between Jan 2000 to Nov 2021 was identified and retrieved from Web of Science (WoS) databases. Bibliometric analysis and visualization, including annual outputs, core journals, keywords, co-authorship, citation, and co-cited analysis were carried out using software like R, VOSviewer, Citespace, Scimago, and Pajek. Correlation analysis using quantitative and qualitative indicators, such as publication and citation counts, H-index, and journal citation reports was carried out using R and Microsoft Excel.
Results: A total of 2551 articles published mainly in the USA, China, and Japan were identified. The University of São Paulo was found to be the most prolific institution, Liu Y the most influential author, and Biological Trace Element Research was the most high-yield journal in this field of research. The top 5 trace elements of interest were divided into two groups; beneficial essential elements including zinc and selenium, and environmental toxicants including copper, cadmium, and aluminum. The top 5 researched keywords were found to be “chronic kidney disease”, “oxidative stress”, “zinc”, “copper”, and “hemodialysis”.
Conclusions: This study conducted a comprehensive bibliometric analysis to summarize the trends and structure of trace elements and CKD. Areas like clusters of nutritional status, outcomes of nephropathy, influences of environmental toxicity, and the metabolism of trace elements have been observed to get increasing attention from researchers.
Security Strategy for Autonomous Vehicle Cyber-Physical Systems Using Transfer Learning
Authors: Alsulami Abdulaziz A. , Al-Haija Qasem Abu , Alturki Badraddin , Alqahtani Ali , Alsini Raed 
Published: November 2022

Abstract
Cyber-physical systems (CPSs) are emergent systems that enable effective real-time communication and collaboration (C&C) of physical components such as control systems, sensors, actuators, and the surrounding environment through a cyber communication infrastructure. As such, autonomous vehicles (AVs) are one of the various fields that have significantly adopted the CPS approach to improving people's lives in smart cities by reducing energy consumption and air pollution. Therefore, autonomous vehicle-cyber physical system (AVs-CPSs) has attracted enormous investments from major corporations and is projected to use widely in the future. However, AV-CPS is vulnerable to cyber and physical threat vectors due to the deep integration of information technology (IT) with the communication process. CPS components such as sensors and control systems through network infrastructure are particularly vulnerable to cyber-attacks targeted by attackers using the communication system. This paper proposes an intelligent intrusion detection system (IIDS) for AVs-CPS using transfer learning to identify cyberattacks launched against connected physical components of AVs through a network infrastructure. First, AV-CPS was developed by implementing the controller area network (CAN) and integrating it into the AV simulation model. Second, the dataset was generated from the AV-CPS. The collected dataset was then preprocessed to be trained and tested via pre-trained CNNs. Third, eight pre-trained networks were implemented, namely, InceptionV3, ResNet-50, ShuffleNet, MobileNetV2, GoogLeNet, ResNet-18, SqueezeNet, and AlexNet. The performance of the implemented models was evaluated. According to the experimental evaluation results, GoogLeNet outperforms all other pre-rained networks scoring an F1- score of 99.47%.
Anti-adhesive activity of some secondary metabolites against Staphylococcus aureus on 3D printing medical materials
Authors: RAOUAN Safae ER , ZOUINE Nouhaila , LACHKAR Mohammed , KORAICHI Saad IBNSOUDA , ABED Soumya EL 
Published: November 2022

Abstract
Recent improvements in 3D printing technology have increased the usage of 3D printed materials in several area. An exciting and emerging area of applying these next-generation manufacturing strategies is in the development of devices for biomedical applications. The main aim of this work was to investigate the effect of tannic acid, gallic acid and epicatechin gallate on the physicochemical characteristics of Acrylonitrile Butadiene-Styrene (ABS) and Nylon 3D printing materials. The results of the contact angle measurements showed a significant change in the physicochemical properties of both surfaces, indicated an increase in electron donor character of 3D printing materials following treatment. Thus, the ABS surfaces treated with tannic acid, gallic acid and epicatechin gallate have become more electron donating. Furthermore, the adhesion of Staphylococcus aureus on untreated and treated materials was evaluated by the scanning electron microscopy (SEM) analysis and the images were treated by MATLAB software. Our results proved the ability of S. aureus to adhere on all materials with a percentage of 77.86% for ABS and 91.62% for Nylon. The SEM has shown that all actives molecules were sufficient to obtain better inhibition of bacterial adhesion, which tannic acid has showed a total inhibition of S. aureus on ABS.
Osmium(VIII) Catalyzed Oxidative Degradation of Paracetamol by Chloramine-T in Aqueous Alkaline Medium - A Computational Screening and Mechanistic Pathway
Authors: Pareek Deepmala , Rolaniya Asha , Goswami Arkja , Bhasin Menka , Ranka Mamta , Sailani Riya 
Published: November 2022

Abstract
The kinetic study between paracetamol and N-chloro-p-toluenesulfonamide (chloramine-T) in the presence of an osmium(VIII) catalyst has been performed in an alkaline medium. The reaction exhibits second-order nature and the catalyst's effect indicates an uncatalyzed reaction simultaneously. The rate is retarded by hydroxide ions. The oxidation product to be quinone oxime is confirmed spectrally in stoichiometry where two moles of oxidant are required for each mole of the substrate. The thermodynamic quantities have also been computed using the Eyring equation. A plausible reaction mechanism is suggested accounting for all the experimental observations. To further support our proposed mechanism, density functional theory (DFT) computations at M06/6-311*G show that activation energy barriers predict the same reactivity trend as shown by the kinetic experiments.
Association of long-term triglyceride-glucose index level and change with the risk of cardiometabolic diseases
Authors: Wenqi Xu , Zhao Haiyan , Gao Lishu , Guo Lu , Liu jianrong , Sun Junyan , Xing Aijun , Chen Shuohua , Wu Shouling , Wu Yuntao 
Published: November 2022

Abstract
Background
The triglyceride-glucose (TyG) index is considered as a pivotal factor for various metabolic, cardiovascular, and cerebrovascular diseases. However, there is currently a paucity of relevant studies on the association between long-term level and change of TyG-index and cardiometabolic diseases (CMDs) risk.We aimed to explore the risk of CMDs in relation to the long-term level and change of TyG-index.
Methods
Based on the prospective cohort study, a total of 36359 subjects who were free of CMDs, had complete data of triglyceride (TG) and fasting blood glucose (FBG) and underwent four health check-ups from 2006 to 2012 consecutively were followed up for CMDs until 2021. The associations between long-term level and change of TyG-index and CMDs risk were assessed by Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CIs). The TyG-index was calculated as ln [TG, mg/dL) × FBG, mg/dL)/2].
Results
During the median observation period of 8 years, 4685 subjects were newly diagnosed with CMDs. In multivariable-adjusted models, a graded positive association was observed between CMDs and long-term TyG-index. Compared with the Q1 group, subjects with the Q2-Q4 group had increased progressively risk of CMDs, with corresponding HRs of 1.64(1.47–1.83), 2.36(2.13–2.62), 3.15(2.84–3.49), respectively. The association was marginally attenuated, after further adjustment for the baseline TyG level. In addition, compared with stable TyG level, both loss and gain in TyG level were associated with increased CMDs risk.
Conclusions
Long-term elevated level and change of TyG-index are risk factors for the incident CMDs. Elevated TyG-index in the early stage remains to exert cumulative effects on the occurrence of CMDs even after accounting for the baseline TyG-index.
Inhibitory effect of gallium nitrate against Staphylococcus aureus and its action on the formation of biofilms on titanium surfaces
Authors: de Assis Amanda Stefanie Jabur , Pegoraro Guilherme Manassés , Germano-Costa Tais , Lima Renata , Pìmentel-Filho Natan de Jesus , Duarte Iolanda Cristina Silveira 
Published: November 2022

Abstract
Under the era of seeking new potential agents able to weaken the development and spread of multi-resistant bacteria towards traditional drugs, the use of the semimetal gallium (Ga3+) has stood out as an important strategy due to its physicochemical characteristics. This study aimed to investigate the effect of gallium nitrate [Ga(NO3)3], an inorganic antimicrobial agent, against the growth and biofilm formation of Staphylococcus aureus. The inhibitory concentration of gallium nitrate was determined in a 96-well microtiter plate in Muller Hinton broth. The potential of the antimicrobial agent to inhibit biofilm formation by S. aureus on titanium surfaces was evaluated by Scanning Electron Microscopy (SEM). The cytotoxicity potential of Ga(NO3)3 was determined on Hamster lung cells. The results showed that the IC50 of gallium nitrate against S. aureus was 1.40 µM, while SEM images revealed that concentrations above 90 µM completely inhibited biofilm formation by S. aureus. This research has shown promising results regarding gallium nitrate’s potential of inhibiting the growth of both planktonic and sessile S. aureus cells. In addition, coating titanium surfaces with Ga(NO3)3 would be an extra alternative to prevent implant-associated infections due to its non-toxicity to cells.
The potential for a combined heat and power (CHP) generation from municipal solid waste: a case study of Croatia
Authors: Traven Luka 
Published: November 2022

Abstract
This paper presents a preliminary analysis of the potential for combined heat and power (CHP) generation in Croatia using municipal solid. Although modern waste-to-energy (WtE) facilities represent a viable and environmentally friendly method of waste treatment, no such plants are currently in operation in Croatia. In this study, the energy potential of municipal solid waste was estimated using data published in official documents and the scientific and technical literature. The results of the analysis point out that the amount of electricity which could be produced from MSW are in the range between 1,79 and 5,72% of the country’s total electricity production depending on the amount diverted to material recovery. In addition, a significant amount of thermal energy could be generated and used for residential and/or industrial applications. To promote this method of waste treatment, a joint effort should be initiated by the Croatian government and the relevant experts aimed at educational campaign for the all the stakeholders so that they are able to make informed opinions about WtE based on facts rather than perceptions.
Delineation of Target Volumes of Neoadjuvant Radiation in Esophageal Squamous Cell Cancer in China: A Consensus Proposal
Authors: Han Dan , Dong jinling , Wang Qifeng , Li Baosheng , Liu Jun , Liu Hui , Qiu Bo , Zhang Wencheng , Yang Hong , Shen Wenbin , Zhang Yaowen , Zhu Xiangzhi , Gao Xinyu , Wang Xinran , Xie Feihong , Wang Yi , Wu Lei , Huang Wei 
Published: November 2022

Abstract
Background: To reach a consensus proposal on the delineation of target volumes of neoadjuvant radiation (nRT) in esophageal squamous cell cancer (ESCC) in China.
Methods: Nine ESCC patients (cases 1-9) who underwent nRT were retrospectively allocated from the Sun Yat-sen University Cancer Center and Shandong Cancer Hospital from February 2020 to June 2021. A working party composed of eight cancer radiotherapy centers delineated the patients’ nRT target volumes for two rounds: the first round of delineation included cases 1–6, and the second round included cases 7–9. After each round of delineation, the working party held an online meeting. Differences in mean undirected Hausdorff distances (Hmean), dice similarity coefficient (DSC), and total volumes between two rounds were investigated with a Mann–Whitney U test.
Results:Delineations in the second round were more consistent between centers (the clinical target volume of the total volume (CTVtotal): mean DSC=0.76–0.81; mean Hmean=2.11–3.14 cm) than in the first round (CTVtotal: mean DSC=0.63–0.64; mean Hmean=5.66–7.34 cm；DSC and Hmean: p<0.050 between rounds). Finally, a proposal and an atlas were obtained for target volumes delineation in patients with ESCC who will be treated with nRT.
Conclusions: involved field irradiation is widely recommended for ESCC treatment in China. Elective nodal irradiation should be administered to the supraclavicular and abdominal lymph nodes, and the range of prophylactic irradiation should not be too large. The formation of the proposal will greatly facilitate the promotion of nRT for ESCC and accurate delineation of target volumes.
Impregnation of pinewood with softwood Kraft lignin
Authors: Borrega Marc 
Published: November 2022

Abstract
Scots pine wood was impregnated under vacuum with an aqueous 60% acetone solution containing about 10% softwood Kraft lignin. The impregnation treatment incorporated 6–8% of lignin (on wood dry mass) to the wood samples and caused a noticeable change in color from pale yellow to dark brown, but microscopy images showed that the lignin remained mostly within 200 µm from the wood surface. Pinewood samples impregnated with lignin and subjected to water leaching trials had a mass loss of only about 1%, in accordance with the insolubility of Kraft lignin in water. The impregnated wood exhibited lower hygroscopicity and considerably lower surface wettability, as indicated by an increase of more than 100% in water contact angle. Lignin impregnation also improved the fungal decay resistance of the wood against the brown rot fungus Rhodonia placenta, but had no effect against Coniophora puteana. On the other hand, lignin impregnation worsened the flammability properties of the pinewood as determined by cone calorimetry, especially in relation to smoke formation. Enhancing the penetration of lignin into the wood structure may help improving further the resistance to fungal decay, while the combination of flame retardant additives with the lignin may be required in order to improve the flammability properties of pinewood.
Recycling History, Maturity, Paleoweathering, and Paleoclimatic Conditions of the Campano-Maastrichtian Sandstones in the Northern Bida Basin, Nigeria
Authors: Adepoju Suraju , Johnson Olusola , Sreeni Bulusu , Akande Samuel 
Published: November 2022

Abstract
The Campanian-Maastrichtian sandstone and siltstone facies of the Bida and Enagi formations, northern Bida Basin Nigeria were logged and sampled. The study aims to evaluate the sandstone's petrographic, mineralogical, and bulk geochemical compositions. This is towards exemplifying sediment recycling, maturity, paleoweathering history, and the prevailing paleoclimatic conditions during depositions in the parts of Bida Basin. Petrography result reveals framework modal composition of Bida Formation sandstones as Q93.51−100F0−2.60L/R0 − 3.90 whereas the Enagi Formation sandstones constituents includes Q84.42−98.72F0−3.75L/R1.18−15.58, thus the Bida Formation sandstones are classified as mostly quartzarenite with minor sublitharenite whereas Enagi Formation sandstone are basically classified as sublitharenite with minor quartzarenite varieties. Mineralogical composition from the X-ray diffractions revealed higher kaolinite contents among the mineral constitutes with relatively high quartz contents while muscovite, anatase and iron-rich minerals (goethite and hematite) were recorded in trace amounts and this suggests significant post-depositional weathering prior to reworking. Higher geochemical weathering indices values, including chemical index of alteration (CIA), chemical index of weathering (CIW), plagioclase index of alteration (PIA), and chemical proxy for alteration (CPA), as well as the ternary A-CN-K and A-CNK-FM plots for both Bida and Enagi formations, suggest an intense weathering and reworking at the source area during late Cretaceous. Geochemical proxies, weathering indices and plots show that the compositionally mature to super mature sediments were deposited under warm, temperate to tropical humid climatic paleoclimatic settings. The light rare earth elements (LREE) enrichment relative to heavy rare earth elements (HREE) and low negative europium (Eu/Eu*) anomaly values with geochemical discrimination plots revealed that the sandstones were sourced from a felsic rocks’ provenance within a passive margin paleotectonic settings. This study concluded that the Campano-Maastrichtian Bida and Enagi formations siliciclastic sediments in the northern Bida sub-Basin, northcentral Nigeria were subjected to extreme weathering, during a warm, temperate to tropical humid climate with the dominance of semi-humid and only brief semi-arid conditions.
A risk prediction model associated with postoperative diarrhea in colorectal cancer patients
Authors: Xu Junbin , Sun Jian , Zhou Jianping , Chen Huijuan 
Published: November 2022

Abstract
Objective: We aim to assess the clinical significance and risk factors of diarrhea for the postoperative colorectal cancer (CRC) patients, and construct a risk prediction model accordingly to estimate risk of diarrhea.
Methods: We retrospectively analyzed 694 postoperative CRC patients in our center from March 2013 to December 2020, which was randomized into the training cohort and the validation cohort in a ratio of 7:3. The least absolute shrinkage and selection operator (Lasso) regression and logistic regression were used to select independent risk factors, develop a risk prediction model and draw a nomogram, respectively. The receiver operating characteristic curve (ROC), calibration curve and decision curve analysis (DCA) were used to assess the predictive power and clinical application value of the model.
Results: The type of antibiotic (OR 7.984, 95% CI 4.293-15.655; P<0.001), time to first postoperative exhaust (OR 0.669, 95% CI 0.582-0. 762; P<0.001), intestinal obstruction (OR 2.227, 95% CI 1.290-3.875; P=0.004), superficial infection (OR 2.965, 95% CI 1.256-7.471; P=0.016), and deep infection (OR 5.981, 95% CI 2.494-15.859; P<0.001) were identified as independent risk factors. The area under curve (AUC) for the training and validation cohorts were 0.778 (95% CI 0.736-0.821) and 0.771 (95% CI 0.700-0.842), respectively. Furthermore, the DCA verified the good effectiveness of this model for clinical application.
Conclusions: For CRC patients with the aforementioned risk factors, postoperative diarrhea should be carefully treated to avoid the bad clinical outcome based on the postoperative diarrhea risk score model.
Kv1.3 blockade alleviates white matter injury through reshaping M1/M2 phenotypes after intracerebral hemorrhage
Authors: Wang Bo , Chen Jie , Wang Shuhong , Chen Lin , Zhang Xuyang , Zhou Tengyuan , Zhong Jun , Zhang Chao , He Yijia , Zuo Yonglin , Feng Hua , Yin Yi , Ge Hongfei 
Published: November 2022

Abstract
Background: White matter injury (WMI) in basal ganglia usually induces long-term disability after intracerebral hemorrhage (ICH). Kv1.3 is highly expressed in microglia, and exaggerates neuroinflammation in neurodegenerative diseases. The present study investigated the role of inflammatory response resulting from Kv1.3 activation in WMI, as well as the effect of Kv1.3 blockade on microglia polarization after ICH.
Methods: ICH was introduced in mice using autologous blood. The expression of Kv1.3 was determined using real-time quantitative polymerase chain reaction (RT-qPCR), immunoblot and immunostaining assays. Then, the effect of administration of 5-(4-Phenoxybutoxy) psoralen (PAP-1), a selectively pharmacological inhibitor of Kv1.3, on functional recovery was investigated using open field test (OFT) and basso mouse score (BMS). Next, the RT-qPCR, immunoblot and enzyme linked immunosorbent assay (ELISA) assays were performed to elucidate the changes of pro-inflammatory and anti-inflammatory factors around hematoma with PAP-1 application after ICH. Thereafter, the role of PAP-1 in regulating microglia polarization was examined through RT-qPCR, immunoblot and immunostaining assays.
Results: After ICH, the expression of Kv1.3 was significantly increased in microglia around hematoma after ICH. The administration of PAP-1 markedly improved neurological outcomes through reducing the accumulation of pro-inflammatory cytokines and upregulating the deposition of anti-inflammatory and neurotrophic factors. The reason for this beneficial effect ascribes to facilitating microglia polarization into M2-like microglia.
Conclusion: Kv1.3 blockade using PAP-1 obviously reduced the accumulation of pro-inflammatory cytokines and upregulated the deposition of anti-inflammatory and neurotrophic factors through facilitating microglia polarization into M2-like microglia. The present study provides evidence Kv1.3 blockade is suitable to mitigate WMI through facilitating microglia transformation into M2-like phenotype after ICH.