bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological Transformation and In Situ Polymerization of Caspase‐3 Responsive Diacetylene‐Containing Lipidated Peptide Amphiphile for Self‐Amplified Cooperative Antitumor Therapy
Authors: Ma Teng , Chen Rong , Lv Niannian , Li Yibin , Yang Zhuo‐Ran , Qin Huimin , Li Zhong'an , Jiang Hao , Zhu Jintao 
Published: October 2022

AbstractIn order to artificially regulate cell behaviors, intracellular polymerization as an emerging chemical technique has attracted much attention. Yet, it is still a challenge to achieve effective intracellular polymerization to conquer tumors in the complex cellular environment. Herein, this work develops a tumor‐targeting and caspase‐3 responsive nanoparticle composed of a diacetylene‐containing lipidated peptide amphiphile and mitochondria‐targeting photosensitizer (C3), which undergoes nanoparticle‐to‐nanofiber transformation and efficient in situ polymerization triggered by photodynamic treatment and activation of caspase‐3. The locational nanofibers on the mitochondria membranes lead to mitochondrial reactive oxygen species (mtROS) burst and self‐amplified circulation, offering persistent high oxidative stress to induce cell apoptosis. This study provides a strategy for greatly enhanced antitumor therapeutic efficacy through mtROS burst and self‐amplified circulation induced by intracellular transformation and in situ polymerization.
Isolating Fe Atoms in N‐Doped Carbon Hollow Nanorods through a ZIF‐Phase‐Transition Strategy for Efficient Oxygen Reduction
Authors: Ma Fei‐Xiang , Liu Zheng‐Qi , Zhang Guobin , Xiong Yu‐Xuan , Zhang Meng‐Tian , Zheng Lirong , Zhen Liang , Xu Cheng‐Yan 
Published: October 2022

AbstractTransition metal–nitrogen–carbon (TM–N–C) catalysts have been intensely investigated to tackle the sluggish oxygen reduction reactions (ORRs), but insufficient accessibility of the active sites limits their performance. Here, by using solid ZIF‐L nanorods as self‐sacrifice templates, a ZIF‐phase‐transition strategy is developed to fabricate ZIF‐8 hollow nanorods with open cavities, which can be subsequently converted to atomically dispersed Fe‐N‐C hollow nanorods (denoted as Fe1–N–C HNRs) through rational carbonization and following fixation of iron atoms. The microstructure observation and X‐ray absorption fine structure analysis confirm abundant Fe–N4 active sites are evenly distributed in the carbon skeleton. Thanks to the highly accessible Fe‐N4 active sites provided by the highly porous and open carbon hollow architecture, the Fe1‐N‐C HNRs exhibit superior ORR activity and stability in alkaline and acidic electrolytes with very positive half‐wave potentials of 0.91 and 0.8 V versus RHE, respectively, both of which surpass those of commercial Pt/C. Remarkably, the dynamic current density (JK) of Fe1‐N‐C HNRs at 0.85 V versus RHE in alkaline media delivers a record value of 148 mA cm−2, 21 times higher than that of Pt/C. The assembled Zn‐air battery using Fe1–N–C HNRs as cathode catalyst exhibits a high peak power density of 208 mW cm−2.
Self‐Supporting Multicomponent Hierarchical Network Aerogel as Sulfur Anchoring‐Catalytic Medium for Highly Stable Lithium–Sulfur Battery
Authors: Tian Shuhao , Huang Juanjuan , Yang Hongcen , Liu Guo , Zeng Qi , Wang Di , Sun Xiao , Tao Kun , Liu Guohan , Peng Shanglong 
Published: October 2022

AbstractThe low utilization rate of active materials, shuttle effect of lithium polysulfides (LiPSs), and slow reaction kinetics lead to the extremely low efficiency and poor high current cycle stability of lithium sulfur batteries (Li–S batteries). In this paper, a self‐supporting multicomponent hierarchical network aerogel is proposed as the modified cathode (S/GO@MX@VS4). It consists of graphene (GO) and MXene nanosheets (MX) loaded with VS4 nanoparticles. The experimental results and first‐principles calculations show that the GO@MX@VS4 aerogel has strong adsorption and reversible conversion effects on LiPSs. It can not only inhibit the shuttle effect and improve the utilization rate of active substances by keeping the chain crystal structure of VS4, but also promote the reversibility and kinetics of the reaction by accelerating the liquid–solid transformation in the reduction process and the decomposition of insoluble Li2S in the oxidation process. The GO@MX@VS4 aerogel modified cathode with a multicomponent synergy exhibits the capacity ratios (Q1/Q2) at different discharge stages is close to the theoretical value (1:2.8), and the capacity decay per cycle is 0.019% in 1200 cycles at 5C. Also, a high areal capacity of 6.90 mAh cm−2 is provided even at high sulfur loading (7.39 mg cm−2) and low electrolyte/sulfur ratio (E/S, 8.0 µL mg−1).
Simulation‐Assisted Localized DNA Logical Circuits for Cancer Biomarkers Detection and Imaging
Authors: Kou Qiaoni , Wang Lei , Zhang Linghao , Ma Liang , Fu Shengnan , Su Xin 
Published: October 2022

AbstractDNA‐based nanodevices equipped with localized modules have been promising probes for biomarker detection. Such devices heavily rely on the intramolecular hybridization reaction. However, there is a lack of mechanistic insights into this reaction that limits the sensing speed and sensitivity. A coarse‐grained model is utilized to simulate the intramolecular hybridization of localized DNA circuits (LDCs) not only optimizing the performance, but also providing mechanistic insights into the hybridization reaction. The simulation guided‐LDCs enable the detection of multiple biomarkers with high sensitivity and rapid speed showing good consistency with the simulation. Fluorescence assays demonstrate that the simulation‐guided LDC shows an enhanced sensitivity up to 9.3 times higher than that of the same probes without localization. The detection limits of ATP, miRNA, and APE1 reach 0.14 mM, 0.68 pM, and 0.0074 U mL−1, respectively. The selected LDC is operated in live cells with good success in simultaneously detecting the biomarkers and discriminating between cancer cells and normal cells. LDC is successfully applied to detect the biomarkers in cancer tissues from patients, allowing the discrimination of cancer/adjacent/normal tissues. This work herein presents a design workflow for DNA nanodevices holding great potential for expanding the applications of DNA nanotechnology in diagnostics and therapeutics.
Keeping Superprotonic Conductivity over a Wide Temperature Region via Sulfate Hopping Sites‐Decorated Zirconium‐Oxo Clusters
Authors: Xie Wei‐Lian , Li Xiao‐Min , Lin Jiao‐Min , Dong Long‐zhang , Chen Yu , Li Ning , Shi Jing‐Wen , Liu Jing‐Jing , Liu Jiang , Li Shun‐Li , Lan Ya‐Qian 
Published: October 2022

AbstractMetal‐oxo clusters have emerged as advanced proton conductors with well‐defined and tunable structures. Nevertheless, the exploitation of metal‐oxo clusters with high and stable proton conductivity over a relatively wide temperature range still remains a great challenge. Herein, three sulfate groups decorated zirconium‐oxo clusters (Zr6, Zr18, and Zr70) as proton conductors are reported, which exhibit ultrahigh bulk proton conductivities of 1.71 × 10−1, 2.01 × 10−2, and 3.73 × 10−2 S cm−1 under 70 °C and 98% relative humidity (RH), respectively. Remarkably, Zr6 and Zr70 with multiple sulfate groups as proton hopping sites show ultralow activation energies of 0.22 and 0.18 eV, respectively, and stable bulk conductivities of >10−2 S cm−1 between 30 and 70 °C at 98% RH. Moreover, a time‐dependent proton conductivity test reveals that the best performing Zr6 can maintain high proton conductivity up to 15 h with negligible loss at 70 °C and 98% RH, representing one of the best crystalline cluster‐based proton conducting materials.
The Advance and Critical Functions of Energetic Carbon Dots in Carbon Dioxide Photo/Electroreduction Reactions
Authors: Bao Kaili , Shi Jie , Liao Fan , Huang Hui , Liu Yang , Kang Zhenhui 
Published: October 2022

AbstractAs a unique carbon‐based nano material, carbon dots (CDs) have attracted great attention because of their special structures and properties, and have been widely used in various fields, such as bio‐imaging technology, catalyst design, pollutant degradation, chemical analysis, clean energy development and so on. CDs are used as catalysts or cocatalysts for multiple energy conversion reactions due to their advantages of valid visible light utilization, fast transmission of charge carriers, excellent catalytic activity, and good electrical conductivity. This review first summarizes the basic structure and properties of CDs. The advance and critical functions of energetic CDs in carbon dioxide photo/electroreduction reactions are discussed in detail. Due to the excellent optical absorption, electron transfer properties and good conductivity of CDs, they can enhance catalytic activity and stability effectively. In the end, the existing problems and future development opportunities of CDs‐based catalysts in CO2 reduction reaction are proposed and outlined.
Vortex Flow‐controlled Circularly Polarized Luminescence of Achiral Pt(II) Complex Aggregates Assembled at the Air‐Water Interface
Authors: Maeda Takatoshi , Mori Taizo , Ikeshita Masahiro , Ma Shing Cho , Muller Gilles , Ariga Katsuhiko , Naota Takeshi 
Published: October 2022

AbstractCircularly polarized luminescence (CPL) has been researched for various applications by control of characteristics such as chirality and magnitude. Supramolecular chirality has been prepared by vortex motion as a mechanical stimulus; however, CPL has yet to be controlled precisely and reproducibly. In this work, the first precise control of CPL under vortex flow conditions at an air‐water interface is reported. The supramolecular chirality of aggregates consisting of an achiral trans‐bis(salicylaldiminato)Pt(II) complex bearing hexadecyl chains is induced and controlled with vortex flow at the air‐water interface, whereas the complex naturally forms an achiral amorphous solid with non‐chiroptical properties under non‐vortex conditions. The CPL direction and magnitude (glum value) of the Pt(II) complex aggregates can be adjusted precisely according to the vortex conditions, including the rotatory direction and flow rate. Vortex‐flow‐induced emission enhancement is also observed upon an increase in the rate of the vortex flow.
Stability indicating validated high‐performance liquid chromatography method for simultaneous estimation of chlorin e6 and curcumin in bulk and drug‐loaded lipidic nanoformulation
Authors: Jain Rupesh , Dubey Sunil Kumar , Singhvi Gautam 
Published: October 2022

AbstractChlorin e6 and curcumin are often used in the treatment of various cancers, including breast, skin, colon, and lung cancer. The present objective of this study is to develop a simple, sensitive, precise, and selective reversed‐phase high‐performance liquid chromatography analytical method for the estimation of curcumin and chlorin e6. Curcumin and chlorin e6 are both estimated simultaneously in bulk and on nanocarriers based formulations. The efficient chromatographic separation of chlorine e6 and curcumin was obtained using SUPELCO C‐18 column with a mobile phase containing ACN and water (pH 2.6 adjusted with trifluoracetic acid 0.1%) in an isocratic mode at a detection wavelength of 412 nm. The flow rate and column oven temperature were kept at 1 ml/min and 30°C, respectively. The retention times for curcumin and chlorin e6 were found to be 11.7 and 13.5 min, respectively. The simultaneous technique was used to estimate the %drug entrapment efficiency, drug loading, as well as the cumulative percentage of drug release of chlorin e6 and curcumin in‐house designed nanoformulations. %Drug loading and entrapment efficiency were found to be 2.22% and 79.92% for curcumin, while 2.43% and 89.47% for chlorin e6, respectively.
Tacca Tuber Starch—A Potential Substrate for Enzymatic Production of Glucose Syrup
Authors: Kareem Sarafadeen Olateju , Makinde Modupe Taofikat , Adeleye Tolulope Modupeoluwa , Adebowale Abdulrazaq Adesola , Ibrahim Hussaini Doko , Alabi Fortune M. 
Published: October 2022

AbstractGlucose syrup obtainable from enzymatic hydrolysis of cassava and corn is widely used as sweetener in food and pharmaceutical industries. This study evaluates the potential of starch from Tacca tuber in comparison with starch from cassava tuber to produce glucose syrup using amylase from fungal isolates. Spores of amylase‐producing cultures of Aspergillius niger and Rhizopus oligospora are grown on rice bran medium in solid state fermentation. Starch is obtained from Tacca (Tacca leontopetaloides) and cassava tubers using simple methods of extraction methods. Response Surface Method of the Central Composite Design version 6.0.8 is employed for optimization studies on the effect of pH, temperature, and time of hydrolysis on amylase activities of crude enzyme on the extracted starches. In comparison with cassava starch, physicochemical analysis of the glucose syrup obtained from cassava and Tacca tubers gives brix of 44 ° (cloudy appearance) and 40 ° (colourless in appearance) with a dextrose equivalent of 68.58 and 40.4 and specific gravity 1.200 and 1.169, respectively. An assessment of the microbiological quality of the glucose syrup produced shows no coliform or fungal growth. This study presents the potential of Tacca tuber as an economic and safe alternative to cassava starch for glucose syrup production.
A Targeted Review of Current Progress, Challenges and Future Perspective of g‐C3N4based Hybrid Photocatalyst Toward Multidimensional Applications
Authors: Hayat Asif , Sohail Muhammad , Anwar Usama , Taha T. A. , Qazi H. I. A. , Amina  , Ajmal Zeeshan , Al‐Sehemi Abdullah G. , Algarni Hamed , Al‐Ghamdi Ahmed A. , Amin Mohammed A. , Palamanit Arkom , Nawawi W. I. , Newair Emad F. , Orooji Yasin 
Published: October 2022

AbstractThe increasing demand for searching highly efficient and robust technologies in the context of sustainable energy production totally rely onto the cost‐effective energy efficient production technologies. Solar power technology in this regard will perceived to be extensively employed in a variety of ways in the future ahead, in terms of the combustion of petroleum‐based pollutants, CO2reduction, heterogeneous photocatalysis, as well as the formation of unlimited and sustainable hydrogen gas production. Semiconductor‐based photocatalysis is regarded as potentially sustainable solution in this context. g‐C3N4is classified as non‐metallic semiconductor to overcome this energy demand and enviromental challenges, because of its superior electronic configuration, which has a median band energy of around 2.7 eV, strong photocatalytic stability, and higher light performance. The photocatalytic performance of g‐C3N4is perceived to be inadequate, owing to its small surface area along with high rate of charge recombination. However, various synthetic strategies were applied in order to incorporate g‐C3N4with different guest materials to increase photocatalytic performance. After these fabrication approaches, the photocatalytic activity was enhanced owing to generation of photoinduced electrons and holes, by improving light absorption ability, and boosting surface area, which provides more space for photocatalytic reaction. In this review, various metals, non‐metals, metals oxide, sulfides, and ferrites have been integrated with g‐C3N4to form mono, bimetallic, heterojunction, Z‐scheme, and S‐scheme‐based materials for boosting performance. Also, different varieties of g‐C3N4were utilized for different aspects of photocatalytic application i. e., water reduction, water oxidation, CO2reduction, and photodegradation of dye pollutants, etc. As a consequence, we have assembled a summary of the latest g‐C3N4based materials, their uses in solar energy adaption, and proper management of the environment. This research will further well explain the detail of the mechanism of all these photocatalytic processes for the next steps, as well as the age number of new insights in order to overcome the current challenges.
Adverse effects of chronic ammonia stress on juvenile oriental river prawn (Macrobrachium nipponense) and alteration of glucose and ammonia metabolism
Authors: Wei Shanshan , Zhang Jin , Chen Wanxin , Shen Anfu , Zhou Dongsheng , Zheng Jinxian , Thiam Habib , Ding Zhili , Limbu Samwel Mchele , Kong Youqin 
Published: October 2022

AbstractAmmonia is one of the common stress factors in aquaculture. However, the effect of chronic ammonia exposure in juvenile oriental river prawn (Macrobrachium nipponense) is currently unexplored. This study explored the effects of chronic ammonia on juvenile healthy oriental river prawns. Fifty prawns (0.123 ± 0.003 g) were exposed to 0, 5, and 15 mg/L total ammonia nitrogen (TAN) in triplicates for 28 days. The effects of chronic ammonia challenge were evaluated on growth, antioxidant capacity, hepatopancreas and gill morphology, and glucose and ammonia metabolism. The results showed that, the chronic ammonia exposure reduced significantly survival rate and weight gain of prawns. The prawns exposed to 15 mg/L ammonia had induced oxidative stress. However, the prawn exposed to 15 mg/L ammonia had significantly lower aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and acid phosphatase activities in the serum. Furthermore, exposure of prawns to 15 mg/L ammonia increased the activities of hexokinase, pyruvate kinase, pyruvate and lactic acid content, and glutamine synthase activity. However, the prawns exposed to 15 mg/L ammonia, reduced succinic dehydrogenase, 6‐phosphogluconic dehydrogenase, phosphoenolpyruvate carboxykinase, glutamate synthase, and glutamate dehydrogenase activities but increased ammonia content in serum. The exposure of ammonia deformed lumen, damaged basement membrane and decreased secretory cells in the hepatopancreas, disordered gill epithelial and pillar cells, and caused gill filament base vacuolation. Our study indicates that chronic ammonia stress impairs growth performance, tissue morphology, induces oxidative stress, and alters glucose and ammonia metabolism in juvenile oriental river prawns.
Health economic modeling for Alzheimer's disease: Expert perspectives
Authors: Landeiro Filipa , Morton Jasmine , Gustavsson Anders , Potashman Michele , Lecomte Pascal , Belger Mark , Thompson Robin , Roncancio‐Diaz Emilse , Jhuti Gurleen , Butler Christopher , Jönsson Linus , Handels Ron , Gray Alastair M. ,   the ROADMAP study
Published: October 2022

AbstractThe successful development of an economic model for the evaluation of future Alzheimer's disease (AD) interventions is critical to accurately inform policy makers and payers. As our understanding of AD expands, this becomes an increasingly complex and challenging goal. Advances in diagnostic techniques for AD and the prospect of disease‐modifying treatments raise an urgent need to define specifications for future economic models and to ensure that the necessary data to populate them are available. This Perspective article provides expert opinions from health economists and governmental agency representatives on how future economic models for AD might be structured, validated, and reported. We aim to stimulate much‐needed discussion about the detailed specification of future health economic models for AD.
The Research Data Alliance Interest Group on Agricultural Data: Supporting a Global Community of Practice
Authors: Bertin Patrícia Rocha Bello , Parr Cynthia , Drucker Debora Pignatari , Subirats Imma 
Published: October 2022

AbstractEfforts to address equity and inclusion in agricultural data infrastructures face numerous challenges. People and networks are widely distributed geographically. This means some solutions to data problems may arise regionally and independently, yet many people are not easily able to engage with their distant colleagues to learn about them or collaborate. In general, constraints on funding for such projects are often national rather than international, and travel funding is not equally distributed. Finally, the breadth of activity means interdisciplinary communication is important but difficult and hard to sustain. Addressing these challenges, the Research Data Alliance (RDA) has been a home for the Interest Group on Agricultural Data (IGAD) since 2013. In 2021, IGAD became the first example of a new type of RDA group – a Community of Practice. A future goal is to use this community of practice to put good regional or national work into practice via inclusive collaborations. This chapter reflects on the lessons learnt from the IGAD community of practice in its attempts to include new voices around the world.
Baladi Seeds in the oPt: Populations as Objects of Preservation and Units of Analysis
Authors: Fullilove Courtney , Alimari Abdallah 
Published: October 2022

AbstractThis essay argues that shortcomings in our approaches to global agriculture and its data infrastructures are attributable in part to a constricted application of population concepts derived from biological sciences in the context of international development. Using Palestine as a case study, this chapter examines the category ofbaladiseeds as a community-generated characterization of population, and one which arguably defies reduction to data. Drawing on quantitative research on farmer participation in informal seed production for wheat in the occupied Palestinian territories (oPt) and oral histories of farmers in the West Bank, this chapter analyzes the relation between participatory plant breeding initiatives, heritage narratives, and international agricultural research in renderingbaladiseeds legible for archiving. It considers the multiple technological practices through which these institutions characterize and manage access to cultivated seeds, and how they differently approach problems of standardization, scalability, and variability. Through case studies of national and local seed saving initiatives, it asks, in turn, whetherbaladiseeds can be reduced to data, how they might be reduced to data, and whether they should be reduced to data.
Data Management in Multi-disciplinary African RTB Crop Breeding Programs
Authors: Agbona Afolabi , Peteti Prasad , Teeken Béla , Olaosebikan Olamide , Bello Abolore , Parkes Elizabeth , Rabbi Ismail , Mueller Lukas , Egesi Chiedozie , Kulakow Peter 
Published: October 2022

AbstractQuality phenotype and genotype data are important for the success of a breeding program. Like most programs, African breeding programs generate large multi-disciplinary phenotypic and genotypic datasets from several locations, that must be carefully managed through the use of an appropriate database management system (DBMS) in order to generate reliable and accurate information for breeding-decisions. A DBMS is essential in data collection, storage, retrieval, validation, curation and analysis in plant breeding programs to enhance the ultimate goal of increasing genetic gain. The International Institute of Tropical Agriculture (IITA), working on the roots, tubers and banana (RTB) crops like cassava, yam, banana and plantain has deployed a FAIR-compliant (Findable, Accessible, Interoperable, Reusable) database; BREEDBASE. The functionalities of this database in data management and analysis have been instrumental in achieving breeding goals. Standard Operating Procedures (SOP) for each breeding process have been developed to allow a cognitive walkthrough for users. This has further helped to increase the usage and enhance the acceptability of the system. The wide acceptability gained among breeders in global cassava research programs has resulted in improvements in the precision and quality of genotype and phenotype data, and subsequent improvement in achievement of breeding program goals. Several innovative gender responsive approaches and initiatives have identified users and their preferences which have informed improved customer and product profiles. A remaining bottleneck is the effective linking of data on preferences and social information of crop users with technical breeding data to make this process more effective.