bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEDM: A Multi-task Learning Model for Persona-aware Emoji-embedded Dialogue Generation
Authors: Zhao Sirui , Jiang Hongyu , Tao Hanqing , Zha Rui , Zhang Kun , Xu Tong , Chen Enhong 
Published: November 2022

As a vivid and linguistic symbol, Emojis have become a prevailing medium interspersed in text-based communication (e.g., social media and chit-chat) to express emotions, attitudes, and situations. Generally speaking, a social-oriented chatbot that can generate appropriate Emoji-embedded responses would be much more competitive, making communications more fun, engaging, and human-like. However, the current Emoji-related research is still in its infancy, leading to an awkward situation of data deficiency. How to develop an Emoji-embedded dialogue system while addressing the lack of data will be interesting and meaningful for the application of future AI. To bridge this gap, we propose a multi-task learning method for persona-aware Emoji-embedded dialogue generation in this article. Specifically, as the benchmark of model training and evaluation, which includes 1.2 million Emoji-embedded tweets and 1.1 million post-response pairs, we first construct a dataset named
EmojiTweet
to handle the data deficiency problem. Then, a Seq2Seq-based model with multi-task learning is designed to simultaneously learn response generation and Emoji embedding from the constructed non-Emoji dialogue and Emoji-embedded monologue data. Afterward, we incorporate persona factors into our model by adopting persona fusion and personalized bias methods to deliver personalized dialogues with more accurately selected Emojis. Finally, we conduct extensive experiments, where the experimental results and evaluations demonstrate that our model has three key benefits: improved dialogue quality, higher user engagement, and not relying on large-scale Emoji-embedded dialogue data representing specific personas.
EmojiTweet
will be published publicly via
https://mea-lab-421.github.io/EmojiTweet/
.
Geographic Patterns in U.S. Lung Cancer Mortality and Cigarette Smoking
Authors: Shreves Alaina H. , Buller Ian D. , Chase Elizabeth , Creutzfeldt Hannah , Fisher Jared A. , Graubard Barry I. , Hoover Robert N. , Silverman Debra T. , Devesa Susan S. , Jones Rena R. 
Published: November 2022

AbstractBackground:Despite the success of smoking cessation campaigns, lung cancer remains the leading cause of cancer death in the U.S. Variations in smoking behavior and lung cancer mortality are evident by sex and region.Methods:Applying geospatial methods to lung cancer mortality data from the National Vital Statistics System and county-level estimates of smoking prevalences from the NCI's Small Area Estimates of Cancer-Related Measures, we evaluated patterns in lung cancer mortality rates (2005–2018) in relation to patterns in ever cigarette smoking prevalences (1997–2003).Results:Overall, ever smoking spatial patterns were generally associated with lung cancer mortality rates, which were elevated in the Appalachian region and lower in the West for both sexes. However, we also observed geographic variation in mortality rates that is not explained by smoking. Using Lee's L statistic for assessing bivariate spatial association, we identified counties where the ever smoking prevalence was low and lung cancer rates were high. We observed a significant cluster of counties (n = 25; P values ranging from 0.001 to 0.04) with low ever smoking prevalence and high mortality rates among females around the Mississippi River region south of St. Louis, Missouri and a similar and smaller cluster among males in Western Mississippi (n = 12; P values ranging from 0.002 to 0.03) that has not been previously described.Conclusions:Our analyses identified U.S. counties where factors other than smoking may be driving lung cancer mortality.Impact:These novel findings highlight areas where investigation of environmental and other risk factors for lung cancer is needed.
HER2 Copy Number and Resistance Mechanisms in Patients with HER2-positive Advanced Gastric Cancer Receiving Initial Trastuzumab-based Therapy in JACOB Trial
Authors: Pietrantonio Filippo , Manca Paolo , Bellomo Sara Erika , Corso Simona , Raimondi Alessandra , Berrino Enrico , Morano Federica , Migliore Cristina , Niger Monica , Castagnoli Lorenzo , Pupa Serenella Maria , Marchiò Caterina , Di Bartolomeo Maria , Restuccia Eleonora , Lambertini Chiara , Tabernero Josep , Giordano Silvia 
Published: November 2022

Abstract

Purpose:
In JACOB trial, pertuzumab added to trastuzumab-chemotherapy did not significantly improve survival of patients with HER2-positive metastatic gastric cancer, despite 3.3 months increase versus placebo. HER2 copy-number variation (CNV) and AMNESIA panel encompassing primary resistance alterations (KRAS/PIK3CA/MET mutations, KRAS/EGFR/MET amplifications) may improve patients’ selection for HER2 inhibition.

Experimental Design:
In a post hoc analysis of JACOB on 327 samples successfully sequenced by next-generation sequencing (NGS; Oncomine Focus DNA), HER2 CNV, HER2 expression by IHC, and AMNESIA were correlated with overall response rate (ORR), progression-free survival (PFS), and overall survival (OS) by univariable/multivariable models.

Results:
Median HER2 CNV was 4.7 (interquartile range, 2.2–16.9). HER2 CNV-high versus low using the median as cutoff was associated with longer median PFS (10.5 vs. 6.4 months; HR = 0.48; 95% confidence interval: 0.38–0.62; P &lt; 0.001) and OS (20.3 vs. 13.0 months; HR = 0.54; 0.42–0.72; P &lt; 0.001). Combining HER2 CNV and IHC improved discriminative ability, with better outcomes restricted to HER2-high/HER2 3+ subgroup. AMNESIA positivity was found in 51 (16%), with unadjusted HR = 1.35 (0.98–1.86) for PFS; 1.43 (1.00–2.03) for OS.
In multivariable models, only HER2 CNV status remained significant for PFS (P &lt; 0.001) and OS (P = 0.004). Higher ORR was significantly associated with IHC 3+ [61% vs. 34% in 2+; OR = 3.11 (1.89–5.17)] and HER2-high [59% vs. 43% in HER2-low; OR = 1.84 (1.16–2.94)], with highest OR in the top CNV quartile. These biomarkers were not associated with treatment effect of pertuzumab.

Conclusions:
HER2 CNV-high assessed by NGS may be associated with better ORR, PFS, and OS in a JACOB subgroup, especially if combined with HER2 3+. The negative prognostic role of AMNESIA requires further clinical validation.
Repair of Limb Ischemia Is Dependent on Hematopoietic Stem Cell Specific-SHP-1 Regulation of TGF-β1
Authors: Wang Chen , Nistala Ravi , Cao Min , Li De-Pei , Pan Yi , Golzy Mojgan , Cui Yuqi , Liu Zhenguo , Kang XunLei 
Published: November 2022

Background:
Hematopoietic stem cell (HSC) therapy has shown promise for tissue regeneration after ischemia. Therefore, there is a need to understand mechanisms underlying endogenous HSCs activation in response to ischemic stress and coordination of angiogenesis and repair. SHP-1 plays important roles in HSC quiescence and differentiation by regulation of TGF-β1 signaling. TGF-β1 promotes angiogenesis by stimulating stem cells to secrete growth factors to initiate the formation of blood vessels and later aid in their maturation. We propose that SHP-1 responds to ischemia stress in HSC and progenitor cells (HSPC) via regulation of TGF-β1.

Methods:

A mouse hind limb ischemia model was used. Local blood perfusion in the limbs was determined using laser doppler perfusion imaging. The number of positive blood vessels per square millimeter, as well as blood vessel diameter (μm) and area (μm
2
), were calculated. Hematopoietic cells were analyzed using flow cytometry. The bone marrow transplantation assay was performed to measure HSC reconstitution.

Results:
After femoral artery ligation, TGF-β1 was initially decreased in the bone marrow by day 3 of ischemia, followed by an increase on day 7. This pattern was opposite to that in the peripheral blood, which is concordant with the response of HSC to ischemic stress. In contrast, SHP-1 deficiency in HSC is associated with irreversible activation of HSPCs in the bone marrow and increased circulating HSPCs in peripheral blood following limb ischemia. In addition, there was augmented auto-induction of TGF-β1 and sustained inactivation of SHP-1-Smad2 signaling, which impacted TGF-β1 expression in HSPCs in circulation. Importantly, restoration of normal T GF-β1 oscillations helped in the recovery of limb repair and function.

Conclusions:
HSPC-SHP-1-mediated regulation of TGF-β1 in both bone marrow and peripheral blood is required for a normal response to ischemic stress.
Reading the Confucian Cosmology of the Book of Changes as an Aestheticism
Authors: Ames Roger T. 
Published: November 2022

Abstract
This early Chinese cosmology made explicit in the Book of Changes that serves as the evolving interpretive context for the Confucian tradition is fundamentally an aestheticism in which each person is a specific focus within which the unbounded field of experience is implicated. What in Whiteheadian terms makes this Confucian cosmology an aesthetic order rather than reductionistic rational order, is that it is holistic, unbounded, inclusive, and resolutely anarchic. This is but to say that, in the patterned order of the cosmos in which no single privileged order predominates, all things without exception not only have their own unique role in aspiring to make the most of themselves, but by participating fully in this process of identity formation itself they become collaborators in the production of the contrapuntal harmony of the social, natural, and cosmic order.
John Dewey, Eastern Philosophy, and the American Avant-Garde: Art and Education in Becoming
Authors: Granger David A. 
Published: November 2022

Abstract
This article begins with a brief comparative analysis of John Dewey’s pragmatic naturalism and several prominent themes from Zen and Confucianism often associated with Dewey. These conceptual themes are then used to examine the combined influence of Dewey and Eastern philosophy on two leading 20th Century American avant-garde artists, John Cage and Allan Kaprow. It is then argued that the work of these artists suggests avenues for cultural enrichment and personal growth and renewal through the arts that reject the dualistic and reductionist premises of Western liberal individualism and its excesses; the disembodied and detached subject of Descartes; the invariant “true” or essential self of Plato; de-situated and compartmentalized views of human experience; and the supposition that the arts are superfluous adornments to the more practical affairs of daily living, all of which tend to disrupt democratic forms of life but remain commonplace in prevailing sociocultural norms and institutional practices (including formal schooling) in the U.S.
Self-Cultivation Through the Art of Calligraphy: From Past to the Future
Authors: Hung Ruyu 
Published: November 2022

Abstract
Aesthetic education plays an important role for the cultivation of self in Chinese tradition. In Chinese tradition, philosophy, education, ethics, and metaphysics are closely interwoven. Confucius takes the educated person as one who develops and optimises her potential in every aspect of life including knowledge, skills, habits of mind, manners and dispositions, and artistic taste. The aim of Confucian education is to ‘develop a whole person’ – chéngrén (成人 or 成為全人). There are many different approaches to the cultivation of the whole human person such as the study of classics, moral refinement, spiritual practice, and artistic education. Among the various different art media, calligraphy in Chinese tradition occupies a special and irreplaceable status. However, in the modern times the most radical changes of calligraphy have taken place in the content and artistic expression, the way of writing, the materials, the utensils, and the cultural form. The avant-garde art of calligraphy brings a novel perspective of self-cultivation. This article will take the modern artist XU Bing(徐冰, 1955 -)’s work as the example to examine the meaning of self-cultivation. Overall, this article explores how calligraphy as art is taken as an important means of self-cultivation from the perspectives of tradition and avant-garde. Through history, calligraphy plays a vital role in art and education not only in Chinese culture but also in the global context.
The Arts as Practices of Care in a Socially Just Curriculum
Authors: Mansfield Janet E. 
Published: November 2022

Abstract
If schools are part of our caring infrastructure, then a diminished arts curriculum is an assault on the possibilities for justice and affective equality for students and teachers. Tracing the intimate relationship between the arts and care, I argue that an art-less school environment is indicative of a care-less society. The arts engage both rationalities of, and ‘aesthetics of difference’, enabling an ethics of care. While it retains and critically examines traditional artistic canons, this contemporary notion of aesthetics is non-hierarchical and broader than Kantian variants (the beautiful and the ugly). Transcending paltry modes of moral reasoning around curriculum, it interrogates the “culture of neglect” surrounding the liberal individual imposed by 40 years of miserable neoliberal governmentality, and, through recognising and celebrating the signifying power of the arts, advocates for a rich, inclusive resistance which is vital when our judgment is deeply challenged by virtual and simulated worlds.
The primary energy factor and carbon intensity of waste energy
Authors: Hitchin Roger 
Published: November 2022

The energy performance of appliances, buildings and groups of buildings is commonly assessed in terms of equivalent carbon emissions or primary energy, usually following procedures defined by regulations. The most appropriate treatment of energy (usually heat) that is rejected as waste from one process, but which may be a useful input to another process, is not obvious and has proved to be problematic. This note describes and illustrates how the situation can be handled by adapting a procedure that is already in use for somewhat similar purposes. The direct users of the approach are likely to be developers and system designers, but since the procedures are often set by regulation, the most important potential users are those responsible for the regulations The principal features of the procedure are that • The use of waste energy reduces the primary energy (or carbon emissions) attributed to the “donor” process: by allocating some of it to the eventual user: an equitable principle. • The total primary energy (or carbon emissions) of the output streams equals the input to the transformation process: a fundamental requirement • The PEF values of outputs are never negative: required for physical plausibility • If there is only one useful output, all the primary energy is assigned to it: for consistency with the fundamental assumptions of the policy metric • The PEF assigned to the recipient user is lower than that of the alternative supply (if its PEF is zero, so is the that of the waste heat) The principal challenge is the need to define a “counterfactual” alternative source of energy for the recipient’s energy needs: options for this this discussed in the note Practical application: The question of the most appropriate convention for the assignment of primary energy and carbon emissions to the application of energy flows that have traditionally considered to be waste has gained importance in recent years, especially in the context of energy distribution systems that transfer energy between buildings. It seems reasonable that the “donor” of the waste energy should be incentivised by a reduction of the primary energy consumption or carbon emissions that is attributed to them (with the reduction balanced by a compensating attribution to the user of the “waste” energy). This is not reflected by the currently widespread convention that waste energy can always be considered to have a carbon intensity and primary energy factor (PEF) of zero. This Technical Note sets out a procedure to achieve this. It is suggested that its application would result in a more equitable and consistent attribution of primary energy and carbon emissions and therefore more robust design of systems that reuse “waste” energy.
Associations of Hearing Loss and Hearing Aid Use With Cognition, Health-Related Quality of Life, and Depressive Symptoms
Authors: Dillard Lauren K. , Pinto Alex , Mueller Kimberly D. , Schubert Carla R. , Paulsen Adam J. , Merten Natascha , Fischer Mary E. , Tweed Ted S. , Cruickshanks Karen J. 
Published: November 2022

Objectives Determine associations of hearing loss (HL) and hearing aid (HA) use with cognition, health-related quality of life (HRQoL), and depressive symptoms. Methods: Participants were from the Epidemiology of Hearing Loss Study or Beaver Dam Offspring Study. HL was defined as pure-tone average (.5–4.0 kHz) > 25 dB. A principal component analysis of 5 cognitive tasks measured cognition. The SF-12 measured mental and physical HRQoL. The Centers for Epidemiological Studies Depression Scale measured depressive symptoms (score ≥ 16). Regression models returned beta (B) coefficients or odds ratios (OR) with 95% confidence intervals. Results: This study included 3574 participants. HL (vs. none) was associated with poorer cognition (B−.12 [−.18, −.06]), mental (B−.99 [−1.65, −.33]) and physical (B−.76 [−1.50, −.03]) HRQoL, and increased odds of depressive symptoms (OR 1.49 [1.16, 1.91]). HA users had better cognition than non-users. Discussion: HL likely impacts cognition and well-being. HA use may have cognitive benefits.
The ethics of sexual relationships between psychiatrists and trainee psychiatrists in the ‘me too’ era
Authors: Corderoy Amy 
Published: November 2022

Objective Since 2017, the structural dynamics that entrench rape culture, sexual harassment and exploitation have gained increased attention across the globe, particularly in regards to workplaces. This paper aims to review the current RANZCP guidelines and other literature pertaining to the ethics of sexual relationships between psychiatrists and trainees. Conclusions Such relationships involve significant power differentials, which may make them unethical on an individual level. A culture condoning such relationships may also disadvantage women in the workplace. The current RANZCP guidelines on relationships between supervisors and trainees may unfairly disadvantage trainees.
Achilles Tendon, Patellar Tendon, and Femoral Cartilage Thickness in Control vs Asymptomatic Flatfoot Young Adults
Authors: Taş Serkan , Aktaş Arda , Dikici Tahir Fatih , Çekok Fatma Kübra 
Published: November 2022

Background: Changes in lower extremity alignment in individuals with flatfoot may be associated with differences in morphology of the tendons or cartilage in lower extremities. The purpose of the present study was to investigate the potential association of flatfoot with the morphology of the Achilles tendon, patellar tendon, and femoral cartilage. Methods: This study was conducted with 40 participants with flatfoot (28 females, 12 males) and 40 participants with a normal foot posture (28 females, 12 males). The thickness of the Achilles tendon (at points 2 and 3 cm proximal to the superior aspect of the calcaneus), patellar tendon (at the inferior pole of the patella and 1 cm proximal of the inferior pole of the patella), and femoral cartilage (at the intercondylar area, medial condyle, and lateral condyle) was measured by an ultrasonography device. Results: The Achilles tendon thickness at 2 cm ( P = .009) and 3 cm ( P = .010) proximal of the superior aspect of the calcaneus was on average 4% to 6% lower in individuals with flatfoot compared with controls. The cartilage thickness at the intercondylar area ( P = .005) and medial condyle ( P = .018) was on average 8% to 12% greater in individuals with flatfoot; however, the cartilage thickness at the lateral condyle and patellar tendon thickness was similar in both groups. Conclusion: The results obtained suggest that foot posture is associated with the morphology of the Achilles tendon and femoral cartilage. Level of Evidence: Level III, diagnostic comparative study.
Quxie Capsule Alleviates Colitis-associated Colorectal Cancer Through Modulating the Gut Microbiota and Suppressing A. fumigatus-induced Aerobic Glycolysis
Authors: Zhang Zhiyong , Chen Yuxi , Zheng Yaojun , Wang Lei , Shen Sunan , Yang Geliang , Yang Yufei , Wang Tingting 
Published: November 2022

Aim: Quxie capsule (QX), a compound of 21 kinds of Traditional Chinese Medicine (TCM) herbs, has been used to treat patients with metastatic colorectal cancer (mCRC) and could suppress the growth of colon cancer. However, the mechanisms of QX inhibiting colorectal cancer remain unclear. In current study, we attempted to determine the anti-colorectal cancer (CRC) effects of QX and the mechanisms of QX in alleviating colorectal cancer. Methods: A colitis-associated colon cancer (CAC) model was established by intraperitoneally injecting mice with AOM followed by 3 cycles of 2% DSS in water. During establishment of CAC model, we orally gavaged mice with QX. Hematoxylin and eosin (H&E) and immunohistochemistry were performed to assess lesion of the colonic tumors. The expression of pro-inflammatory cytokines in colonic tumors was measured by qPCR. The proportion of immune cells in colonic tumors was analyzed by flow cytometry. Internal transcribed spacer (ITS) sequencing and 16S rRNA gene sequencing were performed to detect intestinal microbiota. The expression of glycolytic related enzymes, lactate production, and extracellular acidification rate (ECAR) were used to assess the level of aerobic glycolysis. Results: QX markedly inhibited intestinal tumorigenesis by decreasing the expression of pro-inflammatory cytokines and the proportion of myeloid-derived suppressor cells (MDSCs), and increasing the proportion of CD8+ T cells in colon tumors. Fecal microbiota sequencing revealed that QX increased the relative abundances of intestinal symbiotic probiotics, such as, Lactobacillus, Bifidobacterium and Faecalibacterium genera. What’s more, opportunistic pathogens, Bacteroides genera and Aspergillus- Aspergillus fumigatus, exhibited remarkably reduced abundances in mice treated with QX compared with untreated CAC mice. Further experiments showed that QX significantly reduced glycolysis of colon tumor and suppressed A. fumigatus-induced glycolytic metabolism of colon cancer cells. Conclusions: QX alleviates the development of CRC at least in part through modulating intestinal microbiota and reducing A. fumigatus-induced aerobic glycolysis of colon cancer cells.