bluuebunny/crossref_metadata_2025_split huggingface dataset:
The brain of the tree pangolin (Manis tricuspis). VIII. The subpallial telencephalon
Authors: Imam Aminu , Bhagwandin Adhil , Ajao Moyosore S. , Manger Paul R. 
Published: June 2022

AbstractThe current study provides a detailed architectural analysis of the subpallial telencephalon of the tree pangolin. In the tree pangolin, the subpallial telencephalon was divided into septal and striatopallidal regions. The septal region contained the septal nuclear complex, diagonal band of Broca, and the bed nuclei of the stria terminalis. The striatopallidal region comprised of the dorsal (caudate, putamen, internal and external globus pallidus) and ventral (nucleus accumbens, olfactory tubercle, ventral pallidum, nucleus basalis, basal part of the substantia innominata, lateral stripe of the striatum, navicular nucleus, and the major island of Calleja) striatopallidal complexes. In the tree pangolin, the organization and numbers of nuclei forming these regions and complexes, their topographical relationships to each other, and the cyto‐, myelo‐, and chemoarchitecture, were found to be very similar to that observed in commonly studied mammals. Minor variations, such as less nuclear parcellation in the bed nuclei of the stria terminalis, may represent species‐specific variations, or may be the result of the limited range of stains used. Given the overall similarity across mammalian species, it appears that the subpallial telencephalon of the mammalian brain is highly conserved in terms of evolutionary changes detectable with the methods used. It is also likely that the functions associated with these nuclei in other mammals can be translated directly to the tree pangolin, albeit with the understanding that the stimuli that produce activity within these regions may be specific to the life history requirements of the tree pangolin.
Assessing patients' attitudes towards telepsychotherapy: The development of the unified theory of acceptance and use of technology‐patient version
Authors: Békés Vera , Doorn Katie Aafjes‐van , Bőthe Beáta 
Published: June 2022

AbstractThis study presents the development of a self‐report measure of patients' attitudes towards telepsychotherapy. The measure is based on a well‐researched model of attitudes towards using technology, the Unified Theory of Acceptance and Use of Technology (UTAUT) framework (Venkatesh et al., 2003). We examined the psychometric properties of the UTAUT adapted for psychotherapy patients (UTAUT‐P) in a sample of 107 psychotherapy patients who received telepsychotherapy via video conferencing during the COVID‐19 pandemic. Exploratory factor analysis resulted in a 14‐item UTAUT‐P version, with four factors—(1) Therapy Quality Expectancy, (2) Convenience, (3) Ease of Use, and (4) Pressure from Others—and was further corroborated by the results of the confirmatory factor analysis. Our results indicated the four‐factor model's adequate fit to the data and demonstrated adequate construct validity and reliability of the UTAUT‐P factors. All factors, except for Ease of Use, were significantly and positively associated with intention to use telepsychotherapy technology in the future. This study complements the research on therapists' attitudes towards telepsychotherapy, based on the therapist version of the UTAUT. The developed 14‐item UTAUT‐P might be a helpful, brief self‐report tool in clinical practice, which might give the patient a voice around the potential use of telepsychotherapy technology in their care. This initial application of the UTAUT‐P patients during the COVID‐19 pandemic offers a building block for future research on patients' attitudes towards telepsychotherapy, outside the context of a forced transition.
Input‐series output‐parallel DC–DC converter based on adaptive coefficient voltage equalization control
Authors: Tang Yu , Zhao Zixiang , Shi Zhe , Guo Yingjun , Sun Hexu 
Published: June 2022

SummaryWith the rapid development of power electronics technology, modular series‐parallel structures have attracted more and more attention due to high reliability and good redundancy. Especially in the occasion of high input voltage and low output voltage, the input‐series output‐parallel (ISOP) DC–DC converter is applied to reduce the stress of the device. Although this modular approach has many advantages, there is a problem of unbalanced voltage and current caused by component parameter errors in each module. Therefore, this paper proposes an inverse droop control equalization method based on coefficient adaptation. This method can not only keep the input voltage sharing (IVS) of the modules among the ISOP system but also solve the problem of the deviation of the traditional inverse droop control output voltage from the reference value, which increases the dynamic response of the system. This article first introduces the principle and control logic of the method and builds a three‐way module ISOP circuit. The experiment verifies the input voltage equalization effect and dynamic performance of the control method on the ISOP system under various working conditions.
Environmental correlates of phenotypic evolution in ecologically diverse Liolaemus lizards
Authors: Edwards Danielle L. , Avila Luciano J. , Martinez Lorena , Sites Jack W. , Morando Mariana 
Published: June 2022

AbstractEvolutionary correlations between phenotypic and environmental traits characterize adaptive radiations. However, the lizard genus Liolaemus, one of the most ecologically diverse terrestrial vertebrate radiations on earth, has so far shown limited or mixed evidence of adaptive diversification in phenotype. Restricted use of comprehensive environmental data, incomplete taxonomic representation and not considering phylogenetic uncertainty may have led to contradictory evidence. We compiled a 26‐taxon dataset for the Liolaemus gracilis species group, representing much of the ecological diversity represented within Liolaemus and used environmental data to characterize how environments occupied by species' relate to phenotypic evolution. Our analyses, explicitly accounting for phylogenetic uncertainty, suggest diversification in phenotypic traits toward the present, with body shape evolution rapidly evolving in this group. Body shape evolution correlates with the occupation of different structural habitats indicated by vegetation axes suggesting species have adapted for maximal locomotory performance in these habitats. Our results also imply that the effects of phylogenetic uncertainty and model misspecification may be more extensive on univariate, relative to multivariate analyses of evolutionary correlations, which is an important consideration in analyzing data from rapidly radiating adaptive radiations.
First insights into female sperm storage duration in tardigrades
Authors: Vecchi Matteo , Chartrain Justine , Puro Simo , Tynkkynen Riikka , Vuori Tommi , Michalczyk Łukasz , Calhim Sara 
Published: June 2022

AbstractFemale sperm storage is ubiquitous in the animal kingdom and it has been shown to be linked to several evolutionary processes, from postcopulatory sexual selection to dispersal. Here we report, for the first time, long‐term sperm storage in females of the tardigrade Macrobiotus polonicus. Females, isolated after a short contact with a male, were able to use the stored sperm for up to 5 weeks (mean of 2 weeks), which translates to a considerable proportion of female post‐mating longevity under controlled laboratory conditions (60% on average). Our study provides the first insights into the duration of sperm storage, an underexplored feature of the reproductive biology of tardigrades. Additionally, we discuss important considerations for reproductive studies on these non‐model animals.
Heavy metals in moss guide environmental justice investigation: A case study using community science in Seattle, WA, USA
Authors: Jovan Sarah E. , Zuidema Christopher , Derrien Monika M. , Bidwell Amanda L. , Brinkley Weston , Smith Robert J. , Blahna Dale , Barnhill Roseann , Gould Linn , Rodríguez Alberto J. , Amacher Michael C. , Abel Troy D. , López Paulina 
Published: June 2022

AbstractHeavy metal concentrations often vary at small spatial scales not captured by air monitoring networks, with implications for environmental justice in industrial‐adjacent communities. Pollutants measured in moss tissues are commonly used as a screening tool to guide use of more expensive resources, like air monitors. Such studies, however, rarely address environmental justice issues or involve the residents and other decision makers expected to utilize results. Here, we piloted a community science approach, engaging over 55 people from nine institutions, to map heavy metals using moss in two industrial‐adjacent neighborhoods. This area, long known for disproportionately poor air quality, health outcomes, and racial inequities, has only one monitor for heavy metals. Thus, an initial understanding of spatial patterns is critical for gauging whether, where, and how to invest further resources toward investigating heavy metals. Local youth‐led sampling of the moss Orthotrichum lyellii from trees across a 250 × 250 m sampling grid (n = 79) and generated data comparable to expert‐collected samples (n = 19). We mapped 21 chemical elements measured in moss, including 6 toxic “priority” metals: arsenic, cadmium, chromium, cobalt, lead, and nickel. Compared to other urban O. lyellii studies, local moss had substantially higher priority metals, especially arsenic and chromium, encouraging community members to investigate further. Potential hotspots of priority metals varied somewhat but tended to peak near the central industrial core where many possible emission sources, including legacy contamination and converge. Informed by these findings, community members successfully advocated regulators for a second study phase—a community‐directed air monitoring campaign to evaluate residents' exposure to heavy metals—as is needed to connect moss results back to the partnership's core goal of understanding drivers of health disparities. This follow‐up campaign will measure metals in the PM10 fraction owing to clues in the current study that airborne soil and dust may be locally important carriers of priority metals. Future work will address how our approach combining bioindicators and community science ultimately affects success addressing longstanding environmental justice concerns. For now, we illustrate the potential to co‐create new knowledge, to help catalyze and strategize next steps, in a complex air quality investigation.
Statistical assessment on determining local presence of rare bat species
Authors: Irvine Kathryn M. , Banner Katharine M. , Stratton Christian , Ford William M. , Reichert Brian E. 
Published: June 2022

AbstractSurveying cryptic, sparsely distributed taxa using autonomous recording units, although cost‐effective, provides imperfect knowledge about species presence. Summertime bat acoustic surveys in North America exemplify the challenges with characterizing sources of uncertainty: observation error, inability to census populations, and natural stochastic variation. Statistical uncertainty, if not considered thoroughly, hampers determining rare species presence accurately and/or estimating rangewide status and trends with suitable precision. Bat acoustic data are processed using an automated workflow in which proprietary or open‐source algorithms assign a species label to each recorded high‐frequency echolocation sequence. A false‐negative occurs, if a species is actually present but not recorded and/or all recordings from the species are of such poor quality that a correct species identity cannot be assigned to any observation. False positives for a focal species are a direct result of the presence and incorrect identification of a recording from another species. We compare four analytical approaches in terms of parameter estimation and their resulting (in)correct decisions regarding species presence or absence using realistic data‐generating scenarios for bat acoustic data within a simulation study. The current standard for deciding species presence or absence uses a multinomial likelihood‐ratio test p value (maximum likelihood estimate [MLE]‐metric) that accounts for known species misidentifications, but not imperfect detection and only returns a binary outcome (evidence of presence or not). We found that the MLE‐metric had estimated median correct decisions less than 60% for presence and greater than 85% for absence. Alternatively, a multispecies count detection model was equivalent to or better than the MLE‐metric for correct claims of rare species presence or absence using the posterior probability a species was present at a site and, importantly, provided unbiased estimates of relative activity and probability of occurrence, creating opportunities for reducing posterior uncertainty through the inclusion of meaningful covariates. Single‐species occupancy models with and without false‐positive detections removed were insufficient for determining local presence because of substantially biased occurrence and detection probabilities. We propose solutions to potential barriers for integrating local, short‐term and rangewide, long‐term acoustic surveys within a cohesive statistical framework that facilitates determining local species presence with uncertainty concurrent with estimating species–environment relationships.
Gold Nanoparticles‐electrochemically Reduced Graphene Oxide/Poly(indole‐5‐carboxylic acid) Nanocomposite for Electrochemical Non‐enzymatic Sensing of Hydrogen Peroxide
Authors: Aydoğdu Tığ Gözde , Zeybek Bülent 
Published: June 2022

AbstractHerein, co‐electrodeposition of AuNPs and ERGO onto GCE was conducted to prepare the modified electrode, GCE/AuNPs‐ERGO. The poly(indole‐5‐carboxylic acid) (P(In‐5‐COOH) was then coated onto the GCE/AuNPs‐ERGO with the help of electropolymerization. FT‐IR, FE‐SEM and EDX, and XRD techniques were employed to characterize the prepared nanocomposite. The nanocomposite modified electrode (GCE/AuNPs‐ERGO/P(In‐5‐COOH)) was examined for the electrochemical reduction of H2O2 using chronoamperometry. A high reduction current for H2O2 was observed due to the synergistic effect between AuNPs‐ERGO and P(In‐5‐COOH). The proposed sensor demonstrated a wide linear range of 0.025–750 μmol L−1, with a LOD of 0.008 μmol L−1 at −0.4 V. Furthermore, the developed sensor was applied for the detection of H2O2 in fetal bovine serum and urine samples.
Male infertility and the impact of lifestyle in the Greek population: A case–control study
Authors: Markantoni Maria , Sarafidou Theologia , Chatziparasidou Alexia , Christoforidis Nicolas , Mamuris Zissis 
Published: June 2022

AbstractBackground and AimsCollection of epidemiological data has become a crucial step in every fertility evaluation, especially regarding idiopathic male infertility. Information on data such as tobacco smoking, alcohol intake, and body mass index can provide crucial information regarding the dynamics between fertility status and everyday practices. We aim to set the base for epidemiological studies on male infertility in the Greek population.MethodsFour hundred and fourteen Greek volunteers were asked to fill in a questionnaire regarding their characteristics and lifestyle preferences, followed by a seminogram. Depending on their answers, they were divided into groups and data were analyzed for correlation with seminogram parameters using Spearman's rank correlation test.ResultsOur results indicate that a high body mass index (BMI) is negatively correlated with all three seminogram parameters (number, motility, and morphology) and exposure to radiation or chemicals is negatively correlated with sperm motility, with a p < 0.01.ConclusionsThese findings indicate negative correlations of BMI and exposure to radiation/chemicals with semen parameters in the Greek population. Such information can be used to plan a diagnostic approach or even therapeutic interventions.
Assessment of DLPNO‐CCSD(T)‐F12 and its use for the formulation of the low‐cost and reliable L‐W1X composite method
Authors: Chan Bun , Karton Amir 
Published: June 2022

AbstractIn the present study, we have investigated the performance of RIJCOSX DLPNO‐CCSD(T)‐F12 methods for a wide range of systems. Calculations with a high‐accuracy option [“DefGrid3 RIJCOSX DLPNO‐CCSD(T1)‐F12”] extrapolated to the complete‐basis‐set limit using the maug‐cc‐pV[D+d,T+d]Z basis sets provides fairly good agreements with the canonical CCSD(T)/CBS reference for a diverse set of thermochemical and kinetic properties [with mean absolute deviations (MADs) of ~1–2 kJ mol−1 except for atomization energies]. On the other hand, the low‐cost “RIJCOSX DLPNO‐CCSD(T)‐F12D” option leads to substantial deviations for certain properties, notably atomization energies (MADs of up to tens of kJ mol−1). With the high‐accuracy CBS approach, we have formulated the L‐W1X method, which further includes a low‐cost core–valence plus scalar‐relativistic term. It shows generally good accuracy. For improved accuracies in specific cases, we advise replacing maug‐cc‐pV(n+d)Z with jun‐cc‐pV(n+d)Z for the calculation of electron affinities, and using well‐constructed isodesmic‐type reactions to obtain atomization energies. For medium‐sized systems, DefGrid3 RIJCOSX DLPNO‐CCSD(T1)‐F12 calculations are several times faster than the corresponding canonical computation; the use of the local approximations (RIJCOSX and DLPNO) leads to a better scaling than that for the canonical calculation (from ~6–7 down to ~2–4 for our test systems). Thus, the DefGrid3 RIJCOSX DLPNO‐CCSD(T1)‐F12 method, and the L‐W1X protocol that based on it, represent a useful means for obtaining accurate thermochemical quantities for larger systems.
Association between genetic variants of microRNA‐21 and microRNA‐155 and systemic lupus erythematosus: A case‐control study from a Chinese population
Authors: Wang Rong , Wei Anji , Zhang Yingjie , Xu Guidan , Nong Xuejuan , Liu Chunhong , Zeng Yonglong , Huang Huatuo , Pang Xiaoxia , Wei Wujun , Wang Chunfang , Huang Huayi 
Published: June 2022

AbstractBackgroundSystemic lupus erythematosus (SLE) is a common autoimmune disease, and its pathogenesis remains unclear. The alteration of genetic materials is believed to play a role in SLE development. This study evaluated the association between the genetic variants of microRNA‐21 (miR‐21) and microRNA‐155 (miR‐155) and SLE.MethodsThe SNaPshot genotyping method was used to detect the genotypes of selected SNPs in patients and controls. The expression of miR‐21 and miR‐155 was analyzed using reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR). The functional annotation and the biological effects of SNPs were assessed by HaploReg V4.1 and Regulome DB V2.0 software. The Hardy–Weinberg equilibrium test was used to gather statistics, and odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated by logistic regression.ResultsThe distribution difference of TA genotype in rs767649 was observed (TA vs. T/T: OR = 0.68, 95%CI, 0.48–0.95, p = 0.026). There was a significant difference in the T/A + A/A (T/A + A/A vs. T/T: OR = 0.68, 95%CI, 0.49–0.94, p = 0.020). A significant difference in T allele distribution was found in the depressed complement of SLE (T vs. A: OR = 0.67, 95%CI, 0.47–0.95, p = 0.026). There were significant differences in genetic variants of rs13137 between the positive and the negative SSB antibodies (Anti‐SSB) (T vs. A: OR = 0.67, 95%CI, 0.47–0.95, p = 0.026; T/A + T/T vs. AA: OR = 2.23, 1.18–4.49, p = 0.013). The expression levels of miR‐21 and miR‐155 were significantly higher in patients than in controls (p < 0.001).ConclusionsThis study provides novel insight that genetic variants of rs767649 and rs13137 are associated with susceptibility to SLE.
Pitt–Hopkins syndrome accompanying hypoxic ischemic encephalopathy in a newborn
Authors: Tas Melda , Kurtulus Mervenur , Gulnerman Elı̇f Keles , Turkyilmaz Canan , Percin Ferda , Ergenekon Ebru , Koc Esin 
Published: June 2022

AbstractHypoxic–ischemic encephalopathy (HIE) is one of the substantial causes of developmental‐cognitive disability in neonates. In this early period, it is difficult to diagnose accompanying or predisposing genetic diseases in HIE patients. Herein, we present a patient with HIE who was diagnosed with Pitt–Hopkins syndrome in the newborn period.
Analysis of the albumin‐bilirubin score as an indicator of improved liver function among hepatitis C virus patients with sustained viral response after direct‐acting antiviral therapy
Authors: Martínez Herreros Ángela , Sangro Bruno , García Rodriguez Alba , Pérez Grijalba Virginia 
Published: June 2022

AbstractBackground and AimTo investigate the performance of the albumin‐bilirubin (ALBI) score as an indicator of improved hepatic function using a cohort of hepatitis C virus (HCV) patients with sustained viral response (SVR) after direct‐acting antiviral therapy (DAA).MethodsHCV patients who achieved SVR after DAAs between 2015 and 2016 were followed for at least 24 months. Changes in ALBI were evaluated in the entire cohort and according to liver function and liver stiffness status at baseline.ResultsFour hundred ninety‐seven patients were enrolled. Exactly 96.92% were in Child–Pugh (CTP) class A, and 42% had grade 2 fibrosis. Median ALBI was −3.02, while 87.7 and 11.3% of patients were in ALBI grades 1 and 2, respectively. ALBI improved significantly over time, particularly in patients who had a worse ALBI at baseline. Exactly 77% of patients initially in ALBI grade 1 and 93.9% of those in ALBI grades 2–3 improved their ALBI score in different amounts. Improved ALBI was observed irrespective of CTP score at baseline. Median ALBI at baseline and after 24 months were −3.03 and −3.27 for CTP 5, 2.02 and −2.88 for CTP 6, and −1.59 and −2.84 for CTP >6. Similarly, a significant improvement in ALBI was observed within each stage of fibrosis at baseline.ConclusionALBI was a good indicator of improved hepatic function in HCV patients with SVR after DAA therapy, able to identify changes even in those patients who started DAA therapy with well‐preserved function and mild fibrosis. This simple, objective, and noninvasive test should be evaluated in other clinical scenarios where liver function is relevant.