bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Stability of Nano‐Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition
Authors: Ramesh Vaijayanthi , Stratmann Nadine , Schaufler Viktor , Angelov Svilen D. , Nordhorn Ilona D. , Heissler Hans E. , Martínez‐Hincapié Ricardo , Čolić Viktor , Rehbock Christoph , Schwabe Kerstin , Karst Uwe , Krauss Joachim K. , Barcikowski Stephan 
Published: September 2022

AbstractThe mechanical stability of implant coatings is crucial for medical approval and transfer to clinical applications. Here, electrophoretic deposition (EPD) is a versatile coating technique, previously shown to cause significant post‐surgery impedance reduction of brain stimulation platinum electrodes. However, the mechanical stability of the resulting coating has been rarely systematically investigated. In this work, pulsed‐DC EPD of laser‐generated platinum nanoparticles (PtNPs) on Pt‐based, 3D neural electrodes is performed and the in vitro mechanical stability is examined using agarose gel, adhesive tape, and ultrasonication‐based stress tests. EPD‐generated coatings are highly stable inside simulated brain environments represented by agarose gel tests as well as after in vivo stimulation experiments. Electrochemical stability of the NP‐modified surfaces is tested via cyclic voltammetry and that multiple scans may improve coating stability could be verified, indicated by higher signal stability following highly invasive adhesive tape stress tests. The brain sections post neural stimulation in rats are analyzed via laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS). Measurements reveal higher levels of Pt near the region stimulated with coated electrodes, in comparison to uncoated controls. Even though local concentrations in the vicinity of the implanted electrode are elevated, the total Pt mass found is below systemic toxicologically relevant concentrations.
Thermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration
Authors: Calder Dax , Fathi Ali , Oveissi Farshad , Maleknia Simin , Abrams Terence , Wang Yiwei , Maitz Joanneke , Tsai Kevin Hung‐Yueh , Maitz Peter , Chrzanowski Wojtek , Canoy Ivan , Menon Vivek Ashoka , Lee Kenneth , Ahern Benjamin J. , Lean Natasha E. , Silva Dina M. , Young Paul M. , Traini Daniela , Ong Hui Xin , Mahmoud Rasoul Seyed , Montazerian Hossein , Khademhosseini Ali , Dehghani Fariba 
Published: September 2022

AbstractInjectable hydrogels can support the body's innate healing capability by providing a temporary matrix for host cell ingrowth and neovascularization. The clinical adoption of current injectable systems remains low due to their cumbersome preparation requirements, device malfunction, product dislodgment during administration, and uncontrolled biological responses at the treatment site. To address these challenges, a fully synthetic and ready‐to‐use injectable biomaterial is engineered that forms an adhesive hydrogel that remains at the administration site regardless of defect anatomy. The product elicits a negligible local inflammatory response and fully resorbs into nontoxic components with minimal impact on internal organs. Preclinical animal studies confirm that the engineered hydrogel upregulates the regeneration of both soft and hard tissues by providing a temporary matrix to support host cell ingrowth and neovascularization. In a pilot clinical trial, the engineered hydrogel is successfully administered to a socket site post tooth extraction and forms adhesive hydrogel that stabilizes blood clot and supports soft and hard tissue regeneration. Accordingly, this injectable hydrogel exhibits high therapeutic potential and can be adopted to address multiple unmet needs in different clinical settings.
Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing
Authors: Liu Xiaowei , Yang Ying , Yu Haojie , Wang Li , Sheng Yan , Huang Zhikun , Yang Jian , Ni Zhipeng , Shen Di 
Published: September 2022

AbstractHydrogel adhesives are hot spots due to their ubiquity and practical relevance. However, achieving a robust wet adhesion is still a challenge due to the preferential formation of hydrogen bonds between interfacial fluids and bulk hydrogel, as well as targeted substrates. Herein, a half‐dry adhesive consisting of a silk fibroin (SF) semi‐interpenetrating network and poly(acrylic acid) covalent network, which can allow a rapid liquid adsorption and repulsion process encountering a wet tissue, is reported. The remaining water enables excellent hydrogel flexibility to a dynamic surface, while the β‐sheet fold endows its tough bulk strength under the peeling‐off process. Notably, the wet adhesion energy versus porcine skin is 1440 J m−2 due to the combination of hydrogen bonds, electrostatic interactions, and chain entanglement derived from SF. In particular, both in vitro and in vivo outcomes indicate excellent hemostatic effects and result in incision closure of skin, artery, gastric perforation, and lung. After the first‐stage closure, polyacrylic‐silk fibroin adhesive (PSA) sealants can detach from the lung surface, fitting well to the healing period. By virtue of the reliable adhesion and good noncytotoxicity, PSA may be a prospective candidate for tissue sealant and drug carrier applications.
Narrowband Emissive Thermally Activated Delayed Fluorescence Materials
Authors: Kim Hyung Jong , Yasuda Takuma 
Published: September 2022

AbstractOrganic thermally activated delayed fluorescence (TADF) materials have attracted significant research interest in the field of organic electronics because of their inherent advantage of 100% exciton utilization capability in organic light‐emitting diodes (OLEDs) without the use of noble metals. However, despite their high internal electroluminescence quantum efficiencies approaching unity, broad emission spectra with sizable full width at half maxima (FWHM; 60–100 nm) present a critical issue that must be solved for their application in ultrahigh‐definition OLED displays. Recently, a new paradigm of TADF materials featuring the multiple resonance (MR) effect based on heteroatom‐doped polycyclic aromatic frameworks, referred to as MR‐TADF materials, has emerged and garnered considerable research interest owing to their remarkable features of efficient narrowband emissions with extremely small FWHMs (≤30 nm). Currently, MR‐TADF materials occupy a prominent position in the cutting‐edge research on organic light‐emitting materials from both chemical and physical perspectives. This review article focuses on recent progress in narrowband emissive MR‐TADF systems from the perspective of molecular design, photophysical properties, and electroluminescence performance in OLEDs. The current status and future prospects of this advanced material technology are discussed comprehensively.
Electrical Detection of Magnetic Skyrmions in a Magnetic Tunnel Junction
Authors: Guang Yao , Zhang Like , Zhang Junwei , Wang Yadong , Zhao Yuelei , Tomasello Riccardo , Zhang Senfu , He Bin , Li Jiahui , Liu Yizhou , Feng Jiafeng , Wei Hongxiang , Carpentieri Mario , Hou Zhipeng , Liu Junming , Peng Yong , Zeng Zhongming , Finocchio Giovanni , Zhang Xixiang , Coey John Michael David , Han Xiufeng , Yu Guoqiang 
Published: September 2022

AbstractMagnetic skyrmions are promising information carriers for dense and energy‐efficient information storage owing to their small size, low driving‐current density, and topological stability. Electrical detection of skyrmions is a crucial requirement to drive skyrmion devices toward applications. The use of a magnetic tunnel junction (MTJ) is commonly suggested for this purpose as MTJs are key spintronic devices for large‐scale commercialization that can convert magnetic textures into electrical signals. To date, however, it has been challenging to realize skyrmions in MTJs due to incompatibility between standard skyrmion materials and highly efficient MTJ electrodes. Here, a material stack combining magnetic multilayers, which host 100 nm scale skyrmions, with a perpendicularly magnetized MTJ, is reported. The devices are designed so that the skyrmions in the multilayer are imprinted into the MTJ's free layer via magnetostatic interactions. The electrical response of a single skyrmion is successfully identified by employing simultaneous imaging of the magnetic texture and the electrical measurement of the MTJ resistance. The results are an important step toward all‐electrical detection of skyrmions.
Edaphic and physiographic attributes and death of cacao trees in drought years
Authors: de Souza Júnior José Olimpio , da Silveira Felipe Gomes Frederico , da Silva Pereira Bruno Laecio , Mateus‐Rodríguez Julian Fernando , Baligar Virupax Chanabasappa , Ahnert Dário 
Published: September 2022

AbstractOccurrence of more frequent events of prolonged periods of low rainfall (drought) in worldwide cacao (Theobroma cacao L.) production zones has not only compromised productivity of small farmers but also crop survival. This study aimed to evaluate how and to what extent cacao tree mortality in dry years is related with variations in soil and physiographic features. The rate of mortality of cacao trees cultivated under an agroforestry system was evaluated over three periods (1994–1995, 2009–2013, and 2015–2019) on 36 plots of a farm in Bahia, Brazil, which has a wide diversity of soils and is established in a region with a subhumid to dry climate. Correlation analyses (single and multiple), cluster analysis, and Tukey tests were performed. The explanatory variables studied were the attributes of two soil layers (physical, mineralogical, and chemical), the diagnostic horizon, and the physiographic attributes (slope, terrain orientation in relation to the sun, and crop shading). The edaphic attributes most related to cacao tree mortality were physical (granulometry, porosity, and density) and mineralogical (Ki), mainly in the subsurface layer. The lowest mortality was observed in Oxisols and on slopes facing south and east. It was possible to establish recommend limits of the most suitable edaphic attributes to ensure greater survival of cacao trees cultivated in regions subject to recurrent water deficit similar to the conditions of this study. These findings can be used to guide farmers on how to mitigate the effect of drought.
[FeFe]‐Hydrogenase In Vitro Maturation
Authors: Pagnier Adrien , Balci Batuhan , Shepard Eric M. , Broderick William E. , Broderick Joan B. 
Published: September 2022

AbstractThe [FeFe]‐hydrogenase H‐cluster is a complex organometallic cofactor whose assembly and installation requires three dedicated accessory proteins referred to as HydE, HydF, and HydG. The roles of these maturases and the precise mechanisms by which they synthesize and insert the H‐cluster are not fully understood. This Minireview will focus on new insights into the [FeFe]‐hydrogenase maturation process that have been provided by in vitro approaches in which the biosynthetic pathway has been partially or fully reconstructed using semisynthetic and enzyme‐based approaches. Specifically, the application of these in vitro, semisynthetic, and fully defined approaches has shed light on the roles of individual maturation enzymes, the nature of H‐cluster assembly intermediates, the molecular precursors of H‐cluster ligands, and the sequence of steps involved in [FeFe]‐hydrogenase maturation.
A Synthetic Cycle for Heteroarene Synthesis by Nitride Insertion**
Authors: Kelly Patrick Q. , Filatov Alexander S. , Levin Mark D. 
Published: September 2022

AbstractRecent interest in skeletal editing necessitates the continued development of reagent classes with the ability to transfer single atoms. Terminal transition metal nitrides hold immense promise for single‐atom transfer, though their use in organic synthesis has so far been limited. Here we demonstrate a synthetic cycle with associated detailed mechanistic studies that primes the development of terminal transition metal nitrides as valuable single‐atom transfer reagents. Specifically, we show [cis‐terpyOsNCl2]PF6inserts nitrogen into indenes to afford isoquinolines. Mechanistic studies for each step (insertion, aromatization, product release, and nitride regeneration) are reported, including crystallographic characterization of diverted intermediates, kinetics, and computational studies. The mechanistic foundation set by this synthetic cycle opens the door to the further development of nitrogen insertion heteroarene syntheses promoted by late transition metal nitrides.
Dually responsive biodegradable drug releasing 3D printed structures
Authors: Dutta Sujan , Cohn Daniel 
Published: September 2022

AbstractThe aim of this study was to develop temperature and pH‐responsive biodegradable 3D printed drug‐releasing constructs using the Digital Light Processing (DLP) printing technique. The printable molecules, named “inks” throughout this study, comprised polyethylene oxide–polypropylene oxide–polyethylene oxide (PEO–PPO–PEO) triblocks and acrylic acid (AAc) that rendered them reverse thermo‐responsive (RTR) and pH‐sensitive, respectively. Additionally, the inks' biodegradability was imparted to them by incorporating lactide (LA) and ε‐caprolactone (CL) units into their composition, while their printability was achieved by end‐capping them with 2‐Isocyanatoethyl methacrylate (IEMA). By fine tuning the LA/CL composition, a broad range of inks displaying different water absorption behavior, biodegradation as well as bovine serum albumin (BSA) release profiles at different conditions. All the hydrogels showed a fast and reversible swelling–deswelling response, as they fluctuated between pH 2.0 and pH 7.4 or between 10 and 37°C. The resultant hydrogels showed good water uptake capacity (6340%) at pH 7.4 and 10°C temperature. BSA release from the loaded 3D printed hydrogel showed a maximum (80.5%) at pH 7.4 and 10°C in comparison to pH 7.4 and 37°C (65%). The proposed dual responsive 3D printed biodegradable hydrogels objects will shed light as a drug carrier.
Polybutadiene derived allophanate as the crosslinker for Diels–Alder type self‐healing polyurethane networks
Authors: Liu Ningning , Zhang Minghao , Yang Rongjie , Wang Bingyu , Yang Wei , Yang Fanzhi , Xia Min , Luo Yunjun 
Published: September 2022

AbstractIntrinsic self‐healing materials have drawn great interest in recent years. The design of novel building blocks is essential for developing polymer networks with different properties. Allophanate is usually regarded as a side product during the preparation of polyurethanes. During the research of self‐healing polyurethane networks, we have studied the terminal functionalization of hydroxyl‐terminated polybutadiene with furfuryl isocyanate and occasionally obtained the furan‐terminated polybutadiene allophanate. The tetra‐branched molecule is employed as the crosslinker in the construction of a series of Diels–Alder type polyurethane networks. These polyurethane networks exhibit good mechanical performance and excellent self‐healing ability. Damages can be healed via the thermo‐promoted dissociation and recombination cycle, giving good to excellent recovery of tensile strength within three cycles of “damage‐repair” processes.
Comparative study using design experiment to assess an anionic dye degradation in aqueous solution through the application of different advanced oxidation processes
Authors: Dadou Salima , Berrama Tarek , Tizi Hayet , Beriber Assia , Zekkaoui Chemseddine 
Published: September 2022

AbstractThis study aims to compare the anionic dye degradation (Titan yellow dye: DY9) in synthetic solution using three advanced oxidation processes, namely, Fenton process (FP) (H2O2/Fe2+), photo‐Fenton process (PhFP) (UV/H2O2/Fe2+), and photocatalytic process (PhCP) (TiO2/UV). To perform this study, design of experiments methodology was applied. A full factorial design was used to investigate the effect of operating parameters on the degradation yield. For each process, four parameters were considered, for “FP” and “PhFP,” the initial dye concentration ([DY9]0), the ratio R1 = [H2O2]/[Fe2+], the ratio R2 = [DY9] / [Fe2+], and the pH of solution and for “PhCP,” the initial dye concentration (([DY9]0), initial concentration of hydrogen peroxide [H2O2], dose of titanium oxide [TiO2], and the pH of solution. The averages of degradation yield obtained are 47.1%, 56.7%, and 68.5% for “FP,” “PhFP,” and “PhCP,” respectively. Main and interaction effects plots were constructed. An interaction index (In (%)) was defined, which allowed to quantify the impact of the interaction on the response. Three regression models were proposed and validated on basis of analysis of variance (ANOVA) and statistical criteria as corrected Akaike Information Criterion (AICc), Mallows Cp statistic, coefficient of determination (R2), and adjusted coefficient of determination (R2adj). These models showed that the “PhCP” model was the most statistically significant, including more interaction effect terms. Iso‐responses curves were plotted to predict the optimal conditions for each process. To achieve a full degradation of DY9, the predicting optimal conditions were expressed on intervals.
DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study
Authors: Kheyrandish Mohammad Reza , Mir Seyed Mostafa , Sheikh Arabi Mehdi 
Published: September 2022

AbstractEsophageal cancer (EC) is a common malignancy with a poor prognosis worldwide. There are two core pathways that repair double‐strand breaks, homologous recombination (HR) and non‐homologous end joining (NHEJ) and numerous proteins are recognized that affect the occurrence of HR and NHEJ. Altered DNA damage response (DDR) pathways are associated with cancer susceptibility and affect therapeutic response and resistance in cancers. DDR pathway alterations in EC are still poorly understood. Therefore, the identification of alterations in specific genes in DDR pathways may potentially result in novel treatments for resistant cancers, especially EC. In this review, we aimed to focus on different aspects of DNA damage and repair processes in EC. Also, we reviewed new therapeutic strategies via targeting DNA repair machinery components.
Cost Effectiveness of Pharmacogenetic Testing for Drugs with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines: A Systematic Review
Authors: Morris Sarah A. , Alsaidi Ashraf T. , Verbyla Allison , Cruz Adilen , Macfarlane Casey , Bauer Joseph , Patel Jai N. 
Published: September 2022

The objective of this study was to evaluate the evidence on cost‐effectiveness of pharmacogenetic (PGx)–guided treatment for drugs with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. A systematic review was conducted using multiple biomedical literature databases from inception to June 2021. Full articles comparing PGx‐guided with nonguided treatment were included for data extraction. Quality of Health Economic Studies (QHES) was used to assess robustness of each study (0–100). Data are reported using descriptive statistics. Of 108 studies evaluating 39 drugs, 77 (71%) showed PGx testing was cost‐effective (CE) (N = 48) or cost‐saving (CS) (N = 29); 21 (20%) were not CE; 10 (9%) were uncertain. Clopidogrel had the most articles (N = 23), of which 22 demonstrated CE or CS, followed by warfarin (N = 16), of which 7 demonstrated CE or CS. Of 26 studies evaluating human leukocyte antigen (HLA) testing for abacavir (N = 8), allopurinol (N = 10), or carbamazepine/phenytoin (N = 8), 15 demonstrated CE or CS. Nine of 11 antidepressant articles demonstrated CE or CS. The median QHES score reflected high‐quality studies (91; range 48–100). Most studies evaluating cost‐effectiveness favored PGx testing. Limited data exist on cost‐effectiveness of preemptive and multigene testing across disease states.
Amorphization‐Activated Copper Indium Core‐Shell Nanoparticles for Stable Syngas Production from Electrochemical CO2 Reduction
Authors: Shen Jieyi , Wang Lishuang , He Xuedong , Wang Shun , Chen Jiadong , Wang Juan , Jin Huile 
Published: September 2022

AbstractElectrochemical carbon dioxide reduction reaction (CO2RR) refers to the conversion of carbon dioxide into compounds with added value through electrolysis. It is still a great challenge to design and manufacture efficient CO2RR catalysts for desired products. Producing syngas via CO2RR is an environmentally friendly way to reduce CO2 in the atmosphere and the dependence on fossil fuels. Herein, a new class of Cu/In2O3 nanoparticles (NPs) with controlled phases and structures were successfully prepared as superior electrocatalysts for CO2RR, where the CO/H2 ratios in syngas on Cu/In2O3 NPs/C−H2 remained about 1 : 2 at a broad potential range and the total faradaic efficiency of H2 and CO always remained about 90 %. Electronic structural analysis revealed that the excellent performance was attributed to the electronic interaction between amorphous In2O3 and Cu. This work broadens the horizons for designing and preparing fascinating electrocatalysts for CO2RR.
Facile Chemical Vapor Modification Strategy to Construct Surface Cyano‐Rich Polymer Carbon Nitrides for Highly Efficient Photocatalytic H2 Evolution
Authors: Wang Ruirui , Cao Xiaohua , Huang Huanan , Ji Xingtao , Chen Xiudong , Liu Jinhang , Yan Ping , Wei Shunhang , Chen Liang , Wang Yawei 
Published: September 2022

AbstractThe surface grafting of electro‐negative cyano groups on polymer carbon nitrides (PCNs) is an effective way to tail their electronic structure. Despite the significant progress in the synthesis of cyano group‐enriched PCN, developing a simple and efficient method remains challenging. Here, a facile strategy was developed for fabricating surface cyano‐rich PCN (PCN‐DM) with a porous structure via chemical vapor modification using diaminomaleonitrile. The cyano groups of diaminomaleonitrile substituted the amino groups on PCN surface via a deamination. The hydrogen production rate of the PCN‐DM was approximately 17 times higher than that of pristine PCN. This significant increase in photocatalytic performance could be assigned to the fusion of cyano groups in the surface of PCN, forming new gap states that broadened the visible‐light harvesting and accelerated charge separation for photoredox reactions. This study unveils a promising approach for incorporating functional units in the design of novel photocatalysts for efficient hydrogen production.