bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hormonal, metabolic, and Vitamin D status variabilities among Saudi women with polycystic ovarian syndrome versus nonpolycystic ovarian syndrome controls
Authors: Sindi Ramya Ahmad 
Published: November 2022

Background:
Vitamin D deficiency in Saudi Arabia is alarmingly high and can affect all human ages. However, the characteristic hormonal and metabolic features, and the systemic Vitamin D levels, among Saudi women with polycystic ovarian syndrome (PCOS) remain largely unknown.

Aims:
This retrospective study aimed to identify the hormonal, metabolic, and Vitamin D status variabilities among infertile Saudi women with PCOS versus those of non-PCOS fertile women as controls.

Materials and Methods:
The medical records of a total of 99 women (49 PCOS and 50 controls), with matched age and body mass index, were analyzed in this study. For each woman who met the study inclusion criteria, the analyzed parameters included the serum levels of 25-hydroxyvitamin D (25(OH) D), sex hormone-binding globulin (SHBG), prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), androgen, total testosterone (TT), estradiol, progesterone, thyroid hormones, the fasting plasma glucose (FPG), and lipid profile concentrations.

Results:
Compared to the controls, women with PCOS had significantly lower levels of 25(OH) D, SHBG, FSH, and estradiol, but they had significantly higher levels of LH, androgen, TT, FPG, total cholesterol, and low-density lipoprotein cholesterol. There were no differences between the two groups regarding the other parameters.

Conclusions:
The present findings highlight the prevalence of sex hormones, metabolic, and Vitamin D status disturbances among Saudi women with PCOS. Large-scale retrospective and prospective studies are therefore essential to realize these findings.
Antibody Responses and Reactogenicity of a Heterologous, Full-Dose Messenger RNA-1273 Booster in Heavily SARS-CoV-2–Exposed CoronaVac-Vaccinated Health-Care Workers in Indonesia: A Real-World Observational Study
Authors: Sinto Robert , Utomo Dwi , Suwarti  , Nelwan Erni J. , Surendra Henry , Natasha Cindy , Fransiska  , Theresia Deborah , Ranitria Adella Faiqa , Subekti Decy , Nuraeni Nunung , Handayani Winahyu , Rahardjani Mutia , Baird J. Kevin , Dunachie Susanna , Shankar Anuraj H. , Hamers Raph L. 
Published: November 2022

ABSTRACT.
Real-world data on heterologous boosting with messenger RNA (mRNA)-1273 (Moderna) after inactivated COVID-19 vaccination are limited. We report mRNA-1273 boosting in heavily SARS-CoV-2–exposed Indonesian health-care workers who received a two-dose CoronaVac 6 months prior. Between August and November 2021, we measured SARS-CoV-2 spike-specific IgG binding antibody (Bab) titers in all 304 participants, and neutralizing antibody titers in a random subset of 71 participants, on stored paired serum samples taken before and 28 days after a full-dose (100-μg) mRNA-1273 booster. At the time of the mRNA-1273 boost, 107 participants (35.2%) were not previously infected (naive vaccinated), 42 (13.8%) were infected before CoronaVac (infected vaccinated), and 155 (51.0%) were infected after CoronaVac (mostly during the Delta wave; vaccinated infected). At time of the mRNA-1273 boost, neutralizing antibodies could still be detected in 83% of participants (59 of 71) overall, 60% of naive-vaccinated participants (15 of 25), 95.7% of vaccinated-infected participants (22 of 23), and 95.7% of infected vaccinated participants (22 of 23). After the mRNA-1273 boost, 100% of participants (71 of 71) had neutralizing antibody activity, with increases in median Bab and neutralizing antibody serum titers of 9.3- and 27.0-fold overall, 89.1- and 2,803.4-fold in naive-vaccinated participants, 15.9- and 19.9-fold in infected-vaccinated participants, and 2.2- and 18.4-fold in vaccinated-infected participants. In the multivariable analysis, Bab titers after the mRNA-1273 boost were greatest in individuals who had a previous virus breakthrough post-CoronaVac, and when a longer time period (> 4 months) had elapsed since the most recent prior “spike antigen exposure” (either second CoronaVac or virus breakthrough). Overall, adverse reactions were mild and short-lived. In conclusion, a full-dose mRNA-1273 booster after CoronaVac was well tolerated and immunogenic after 28 days, including in those with very low antibody levels.
Sensitivity of Antigen, Serology, and Microbiology Assays for Diagnosis of the Subtypes of Chronic Pulmonary Aspergillosis at a Teaching Hospital in São Paulo, Brazil
Authors: de Oliveira Vítor Falcão , Viana Joshua Araújo , Sawamura Marcio Valente Yamada , Magri Adriana Satie Gonçalves Kono , Nathan Costa Andre , Abdala Edson , Mariani Alessandro Wasum , Benard Gil , Chaves Magri Marcello Mihailenko 
Published: November 2022

ABSTRACT.
Chronic pulmonary aspergillosis (CPA) is divided into five subtypes. The diagnosis of CPA is complicated due to poor sensitivity of the laboratory tests. Diagnostic performance of different antigen, serological, and microbiological methods in subtypes of CPA is unknown. The purpose of this study was to evaluate the diagnostic performance in different subtypes of CPA. A total of 91 participants with CPA were included, and the study was performed at Hospital das Clínicas of University of São Paulo. Bronchoalveolar lavage galactomannan (73%, 11/15), serology by immunodiffusion test (81%, 61/75), and histology (78%, 39/50) had the best sensitivity. The counterimmunoelectrophoresis (CIE) titers had a significant statistical difference between the CPA subtypes (P < 0.001), in which the forms chronic fibrosing pulmonary aspergillosis (CFPA) and subacute invasive aspergillosis (SAIA) had higher titers: 1/64 (interquartile range [IQR]: 1/32–1/256) and 1/64 (1/32–1/128). C-reactive protein generally presented lower values (median 15 mg/L, IQR: 6–33), with higher values in SAIA and lower values for Aspergillus nodule. Overall, we found a low diagnostic sensitivity of current tests. Regarding the CPA subtypes, we did not find great differences in the performance of the tests, but it is observed that the inflammatory markers and CIE titers tend to be higher in forms of the more extensive lung parenchyma involvement, such as SAIA and CFPA.
Kinetics of Neutralizing Antibodies against Omicron Variant in Vietnamese Healthcare Workers after Primary Immunization with ChAdOx1-S and Booster Immunization with BNT162b2
Authors: Chau Nguyen Van Vinh , Nguyet Lam Anh , Dung Nguyen Thanh , Quang Vo Minh , Truong Nguyen Thanh , Toan Le Mau , Hung Le Manh , Man Dinh Nguyen Huy , Khoa Dao Bach , Phong Nguyen Thanh , Ngoc Nghiem My , Thao Huynh Phuong , Ty Dinh Thi Bich , Thanh Pham Ba , Ny Nguyen Thi Han , Thanh Le Kim , Thuy Cao Thu , Anh Nguyen To , Hong Nguyen Thi Thu , Nhu Le Nguyen Truc , Yen Lam Minh , Thwaites Guy , Thanh Tran Tan , Tan Le Van , _ _ 
Published: November 2022

ABSTRACT.
We studied the development and persistence of neutralizing antibodies against SARS-CoV-2 ancestral strain, and Delta and Omicron (BA.1 and BA.2) variants in Vietnamese healthcare workers (HCWs) up to 15 weeks after booster vaccination. We included 47 HCWs, including group 1 (G1, N = 21) and group 2 (G2; N = 26) without and with breakthrough Delta variant infection before booster immunization, respectively). The study participants had completed primary immunization with ChAdOx1-S and booster vaccination with BNT162b2. Neutralizing antibodies were measured using a surrogate virus neutralization assay. Of the 21 study participants in G1, neutralizing antibodies against ancestral strain, Delta variant, BA.1, and BA.2 were (almost) abolished at month 8 after the second dose, but all had detectable neutralizing antibodies to the study viruses at week 2 post booster dose. Of the 26 study participants in G2, neutralizing antibody levels to BA.1 and BA.2 were significantly higher than those to the corresponding viruses measured at week 2 post breakthrough infection and before the booster dose. At week 15 post booster vaccination, neutralizing antibodies to BA.1 and BA.2 dropped significantly, with more profound changes observed in those without breakthrough Delta variant infection. Booster vaccination enhanced neutralizing activities against ancestral strain and Delta variant compared with those induced by primary vaccination. These responses were maintained at high levels for at least 15 weeks. Our findings emphasize the importance of the first booster dose in producing cross-neutralizing antibodies against Omicron variant. A second booster to maintain long-term vaccine effectiveness against the currently circulating variants merits further research.
Two Nigerian States (Plateau and Nasarawa) Have Eliminated Transmission of Human Onchocerciasis—A Report of Post-Ivermectin Mass Drug Administration Surveillance
Authors: Miri Emmanuel S. , Eigege Abel , Kahansim Barminas , Nwodu Kenrick , Sambo Yohana , Mancha Bulus , Adelamo Solomon , Umaru John , Kadimbo Jonathan , Danboyi Jacob , Mafuyai Hayward , Makata Emeka , Akpan Nse , Akilah Joel , Igbe Michael , Coalson Jenna , Rakers Lindsay , Griswold Emily , Unnasch Thomas R. , Nwoke B. E. B. , Noland Gregory S. , Richards Frank O. 
Published: November 2022

ABSTRACT.
Transmission of Onchocerca volvulus (causing “river blindness”) was interrupted in two states of Nigeria (Plateau and Nasarawa) in 2017 in accordance with 2016 WHO guidelines. Ivermectin mass drug administration was halted in January 2018, and posttreatment surveillance activities were conducted over a 3-year period. Vector Simulium damnosum s.l. flies were collected during the 2019 (39 sites) and 2020 (42 sites) transmission seasons. Head pools were tested by polymerase chain reaction for the presence of third-stage O. volvulus larvae; 15,585 flies were all negative, demonstrating an infective rate of < 1/2,000 with 95% confidence. In 2021, the Nigerian Federal Ministry of Health declared the two-state area as having eliminated transmission. Plateau and Nasarawa states are the first of 30 endemic states in Nigeria to have met the WHO criteria for onchocerciasis elimination. Post-elimination surveillance will need to continue given the risk of reintroduction of transmission from neighboring states.
Facing two faces of malnutrition among schooling adolescents in North-Central Nigeria
Authors: Omotoso A.B.O , Adediran K.I , Abdulmalik J.O , Omigbodun O.O 
Published: November 2022

Adolescence is a period of transition in which there are unique nutritional requirements. Our study determined the nutritional status of adolescents, schooling in north-central Nigeria. A cross-sectional study was conducted among 512 in-school adolescents. The sociodemographic and anthropometric data were analysed with the Statistical Package for Social Sciences version 22 and the WHO Anthro software (Version 3.1.0) respectively. Chi square statistics tested the association between categorical variables at 5% level of statistical significance. Binary logistic regression analysis determined the predictors of anthropometric indicators. From eight public schools, 512 students were interviewed, 53.5% of which were girls. While 21% were underweight, 20% were overweight, 12.1% were stunted and 0.1% was obese. Being from a polygamous family was predictive of stunting. The dietary pattern was starchy and meat consumption was rare. Meal skipping and snacking were common.
The two faces of malnutrition were common among the adolescent students. There is a need for nutrition education and effective school mental health policies in Nigeria and across Africa. Good nutrition among adolescents has an impact on mental health and education – two promising pillars to support the demographic dividend of Africa’s youthful population.
Impact of environmental degradation on biodiversity conservation in Nigeria
Authors: Mafiana C. F , Jayeola O. A , Iduseri E. O 
Published: November 2022

Biodiversity is critical for sustainability but it is being increasingly threatened by anthropogenic activities, such as abitats’ degradation through deforestation, unsustainable shifting cultivation and draining of wetlands; as well as industrialisation and overexploitation of flora and fauna which includes unsustainable fishing, excessive consumption of fuel wood and overharvesting of medicinal plants. Human modification of the ecosystems does not only lead to biodiversity loss but can also cause a continuous shift in earth’s ecological equilibrium, resulting in degradation and environmental stress. Notably, the United Nations’ Sustainable Development Goal 15 (SDG 15) is aimed at averting this impending crisis. This article examines the impact of environmental degradation and conservation on biodiversity in Nigeria and espouses suggestions towards the attainment of sustainable development goals.
Development of Conflict Management Style Media Development Based on Android to Know the Style of Managing Conflict of High School Students
Authors: Budiarti Qorina Aris , Hariastuti Retno Tri , Sartinah Endang Pudjiastuti 
Published: November 2022

This study aims to develop a set of android CMS (Conflict Management Style) to find out the style of managing conflict among high school students as an important information to reduce conflict appropriately and responsibly that meets the assessment criteria of acceptability includes aspects of usability, feasibility, accuracy and propriety. This research uses the Borg & Gall development research method which includes: (1) preliminary studies; (2) planning; (3) initial product development; (4) testing expert validation; (5) product revision. After that, the data were analyzed using quantitative and qualitative methods. The material expert test assessment shows 92.19%, means that the contents of CMS (Conflict Management Style) android material is very good, no revision needed. Not only that, the Rating media expert test also shows a very good results, which is 100%, it means that this application design can be considered as a very good one. So concluded that the development of android-based conflict management style understanding media to determine students' conflict management styles had met the criteria for good acceptability in the design and content of the discussion, so that the Android CMS (Conflict Management Style) could be used as information to reduce and direct conflict.
Kontekstualisasi Pendidikan Agama Kristen Bagi Remaja
Authors: Tanama Yulia Jayanti , Pakpahan Duma Fitri , Purnama Wahyu Sapta 
Published: November 2022

Usia remaja cenderung kritis tentang segala sesuatu dalam kehidupannya termasuk tentang agama dan iman yang dianutnya maka diperlukan strategi yang tepat untuk menyampaikan kebenaran Alkitab yang dapat diterima secara akal dan dialami dalam kehidupan nyata. Oleh sebab itu, tujuan penelitian untuk mengimplemtentasikan strategi pembelajaran konstekstual dalam pelajaran Pendidikan Agama Kristen serta kontektualitasnya untuk usia remaja. Metode penelitian ini menggunakan metode deskritif kualitatif melalui wawancara, observasi, dan dokumentasi. Hasil penelitian yaitu strategi pembelajaran konstektual merupakan strategi yang sesuai dengan usia remaja karena menarik, menambah pengetahuan, melatih berpikir kritis, serta menantang untuk mampu menganalisis serta dapat diaplikasikan secara nyata pada aspek fisik, emosi, dan minat remaja sesuai kebenaran Firman Tuhan.
High-performance concrete in road pavement construction
Authors: Solovyova V. Ya. , Stepanova I. V. , Razuvaev D. A. 
Published: November 2022

This paper describes that concrete physical and mechanical properties such as density, crack resistance, durability and reliability can be improved with introducing a high-performance chemical additive based on polycarboxylate polymers modiﬁed with electrolytes based on group I metal cations of the main subgroup in D.I. Mendeleev’s table. These high mobility polymers facilitate their diffusion ability. It is recommended to use silicon hydroxide nanoparticle dispersion as an additional component as they have such unique properties as increased reactivity.The superplasticity and reactivity of the complex chemical additive under study proved to increase cement hydration process and enhance the formation of new hydrate phases, which contributed to a greater bending tensile strength and chemical resistance of concrete. The use of this complex chemical additive increased the compressive strength by more than 41 % and the bending tensile strength by 56 %, which contributed to concrete crack resistance.Concrete water resistance was proved to increase by 75 % and corresponded to W14 class while concrete frost resistance increased by 70 % to the value of F2500, and chemical resistance increased by 16 % to the value Kx.s. l 0.93. According to GOST 58895-2020, this advanced concrete corresponds to the concrete with increased chemical resistance.According to the test results of physical and mechanical properties, concrete with this complex chemical additive is recommended to use in federal highway pavement construction.
Rationality participation of members of the Tulip Joint Business Group (KUBE) in corn planting in Pagarawan Village, Merawang District
Authors: Rosmiati Risti , Aimie Sulaiman  , Herdiyanti  
Published: November 2022

The Joint Business Group (KUBE) aims to provide the community with access to potential and resources, hoping that it will be based on community empowerment, so that the process of improving the common good can be more effective and efficient. This study aims to analyze the justification for the participation of KUBE Tulip members in the cultivation of maize when there are obstacles, what causes these obstacles. This research was supplemented by a descriptive qualitative method using methods of data collection through interviews, observation and documentation. This study found that the most dominant action rationality behind KUBE Tulip member participation was instrumental rationality. However, his objective is influenced by affective rationality, which result in a lack of member participation in the implementation of the program. The lack of participation of members is based on the existence of disputes between groups, the diversification of work and the emergence of new habits and is repeated. This rationality is normalized by the members of the group during the execution of the program.
Program Kelompok Usaha Bersama (KUBE) hadir untuk memberikan akses kepada masyarakat terhadap potensi dan sumber dengan harapan berbasis pemberdayaan masyarakat sehingga proses peningkatan kesejahteraan masyarakat dapat berjalan lebih efektif dan efesien. Penelitian ini bertujuan untuk menganalisis rasionalitas yang melatarbelakangi partisipasi anggota KUBE Tulip dalam penanaman jagung, apabila terdapat kendala maka hal apa yang menyebabkan kendala tersebut terjadi. Penelitian ini diselesaikan dengan metode kualitatif deskriptif dengan metode pengumpulan data melalui wawancara, observasi, dan dokumentasi. Penelitian ini menemukan bahwa rasionalitas tindakan yang paling dominan dalam melatarbelakangi partisipasi anggota KUBE Tulip adalah rasionalitas instrumental. Namun tujuan tersebut dipengaruhi oleh rasionalitas afektif sehingga menjadikan kurangnya partisipasi anggota dalam pelaksanaan program. Kurangnya partisipasi anggota kelompok dilandasi oleh adanya perselisihan antar kelompok, adanya diversifikasi pekerjaan, serta munculnya kebiasaan baru dan dilakukan secara berulang. Rasionalitas tersebut dinormalisasikan oleh anggota kelompok dalam menjalankan program.
Hubungan Kepuasan Kerja Perawat dengan Kepatuhan Pemakaian Alat Pelindung Diri di Ruang Rawat Inap Perioperatif
Authors: Astari Astrid Devi , Manurung Idawati , Amperaningsih Yuliati , Nawati Nawati 
Published: November 2022

Tujuan penelitian, mengetahui hubungan antara kepatuhan pemakaian APD dengan kepuasan kerja perawat ruang rawat inap perioperatifÂ di era pandemi. Jenis penelitian kuantitatif dengan desain cross-sectional, memakai kuesioner untuk mengukur kepuasan perawat dan kepatuhan memakai APD, dengan uji statistik Chi Square, di Rumah Sakit Yukum Medical Centre Provinsi Lampung, Juli 2021. Populasi perawat perioperatif, dengan total sampling, 60 perawat. Hasil penelitian, diketahui lebih banyak perawat merasa tidak puas melakukan pekerjaan dengan memakai APD lengkap dan sebagian besar perawat tidak patuh memakai APD, ada hubungan bermakna antara kepuasan kerja perawat dengan kepatuhan memakai APD lengkap, perawat yang tidak puas akan pekerjaannya berpeluang besar untuk tidak patuh memakai APD dengan lengkap.Â Kesimpulan, kepatuhan perawat memakai APD berhubungan dengan kepuasan perawat kerja, semakin puas perawat kerja, semakin patuh mengikuti peraturan, termasuk memakai APD. Disarankan rumah sakit sebaiknya meningkatkan manajemen sehingga semakin menunjang kepatuhan perawat dalam setiap peraturan dan program kerja.
Force based Design Approach for Seismic Evaluation of Padma Multipurpose Bridge Pier at Different Performance Levels
Authors: K. S. Ahmed  , S. M. Moniruzzaman  , Tahsin Reza Hossain  , Shamim Z Bosunia  
Published: November 2022

The Padma Multipurpose Bridge (PMB) is one of the biggest megaprojects of Bangladesh connecting one third of the country with the capital city, Dhaka. The infrastructure is expected to produce considerable uplift on the nation’s transport system, the national and regional economy, employment, household income, and ultimately, poverty reduction. From construction and river management points of view, it is the most difficult and engineering innovation-intenstive project in the world. Hence the Padma Multipurpose Bridge (PMB) required analytical, computational and experimental studies. In this work, a 3D Finite Element (FE) model of the actual PMB containing a single (6x150m) 900m modules has been developed in MIDAS Civil, a commercial computer program for bridges. P-y soil spring model following API guideline has been developed to conform flexible support system of the bridge pier. Following BNBC 2020, the bridge's performance has been evaluated for the 475-year, 975 years, and 2475-year return periods for Service Level, Design Basis and the Maximum Credible Earthquake (MCE), respectively. The forced based design shows that the bridge pier reached only 28% and 36% of its axial and shear capacity respectively for an earthquake return period of 2475 years. On the other hand, the pier has reached a maximum of 41% of its total shear capacity for the same seismic level.
Costa-Gavras
Authors: Michalczyk John J. , Michalczyk Susan A. 
Published: November 2022

Costa-Gavras: Encounters with History explores the life and work of the director intertwined with historical and socio-political events, from the early stages of his career: emigrating to France from Greece in 1955 and first studying at the Sorbonne, then focusing on filmmaking at IDHEC, now La Fémis. He became an internationally respected director, first with his Oscar-award winning film Z (1969) and continued with a vast array of films, including his most recent work, Adults in the Room (2019). His films portray the complexities of human nature, relationships challenged by historical and contemporary socio-political issues. In this overview of the director’s films, the authors shed light on his encounters with history from his youth in war-torn Greece to his later films on immigration, unemployment, global capitalistic greed, and the abuse of political and economic power in Europe.
Costa-Gavras’ films have spanned several decades and several continents, to combat unethical laws and injustice, oppression, legal/illegal violence, and torture. Throughout his evolution in the world of cinema for over half a century as director, writer, and producer, Costa-Gavras has told human-interest stories that entertain and inspire, and that help us better understand ourselves and a fragile, fragmented world.