bluuebunny/crossref_metadata_2025_split huggingface dataset:
Policy and infrastructure challenges influencing ICT implementation in universities: a literature review
Authors: Ntorukiri Timothy Bariu , Kirugua Joseph Muriungi , Kirimi Francis 
Published: December 2022

AbstractInformation and Communication Technology (ICT) has become pivotal in our daily lives and educational institutions' teaching and interaction between instructors and learners. As a result, universities are restructuring their curriculum and classroom instruction bridging the digital gap between education and learning. However, research seldom centers on policies and infrastructure challenges as key ICT implementation factors. Empirical literature identified a substantial technological gap among the ICT policies and infrastructure that significantly influences ICT implementation. The review is essential given the different cultural contexts in which the interplay between ICT implementation, ICT policies, and infrastructure, of which the documentation has been relatively minor. The present study centers on the complex interplay between policy and infrastructural challenges that influence ICT implementation. In line with the study target and contributing to the existing literature, the researcher analyzed the literature drawn from qualitative and quantitative studies from different sources. The review established that ICT implementation depends on policies and relevant ICT infrastructure. Therefore, stakeholders need to intervene and address the challenge of effective ICT implementation. The study findings provide valuable baseline information to stimulate investment in ICT policies and infrastructure to streamline university education by enhancing accessibility, quality, and efficiency through ICT implementation.
Buy America and Buy American: Can Canada Expect a Deal from the Biden Administration?
Authors: DUFOUR GENEVIÈVE , MORIN PIERRE-LUC 
Published: December 2022

AbstractAfter US President Joe Biden took office, some believed he would take a different path from that of his predecessor and that the Trump years were over. However, one of President Biden’s first moves was to strengthen American protectionism by heightening the United States’s “Buy America” and “Buy American” requirements. With this, the American government procurement market started to close off even more, and Canadian suppliers, in turn, grew worried. Given the United States’s international procurement commitments and the specificity of the Buy American Act and the Buy America Policy, this article explores the pathways to favourable treatment of Canadian suppliers in keeping with applicable international trade rules.
The spread of iron in Central Asia: on the etymology of the word for “iron” in Iranian and Tocharian
Authors: Peyrot Michaël , Dragoni Federico , Bernard Chams Benoît 
Published: December 2022

AbstractTocharian B eñcuwo “iron” and Tocharian A añcu* have been connected to the Iranian words for “iron”, notably Khwarezmian hnčw. On the basis of insights into the patterns of borrowings from Khotanese into Tocharian, it is argued that the Tocharian words must have been borrowed from a preform of Khotanese hīśśana- “iron”. Further, a new etymology is proposed for “iron” that accounts for the variation of this word in Iranian. The fact that Tocharian borrowed the word for “iron” from Khotanese, not from the archaic steppe dialect of Iranian that is the source of many other loanwords in Tocharian, suggests that the contacts between this latter dialect and Tocharian took place before iron became widespread in the region.
Low levels of Methyl-CpG binding protein 2 are accompanied by an increased vulnerability to the negative outcomes of stress exposure during childhood in healthy women
Authors: Cosentino Livia , Zidda Francesca , Dukal Helene , Witt Stephanie H. , De Filippis Bianca , Flor Herta 
Published: December 2022

AbstractNumerous mental illnesses arise following stressful events in vulnerable individuals, with females being generally more affected than males. Adverse childhood experiences are known to increase the risk of developing psychopathologies and DNA methylation was demonstrated to drive the long-lasting effects of early life stress and promote stress susceptibility. Methyl-CpG binding protein 2 (MECP2), an X-linked reader of the DNA methylome, is altered in many mental disorders of stress origin, suggesting MECP2 as a marker of stress susceptibility; previous works also suggest a link between MECP2 and early stress experiences. The present work explored whether a reduced expression of MECP2 is paralleled by an increased vulnerability to the negative outcomes of stress exposure during childhood. To this aim, bloodMECP2mRNA levels were analyzed in 63 people without history of mental disorders and traits pertaining to depressive and anxiety symptom clusters were assessed as proxies of the vulnerability to develop stress-related disorders; stress exposure during childhood was also evaluated. Using structural equation modeling, we demonstrate that reducedMECP2expression is accompanied by symptoms of anxiety/depression in association with exposure to stress in early life, selectively in healthy women. These results suggest a gender-specific involvement ofMECP2in the maladaptive outcomes of childhood adversities, and shed new light on the complex biology underlying gender bias in stress susceptibility.
Modern-like deep water circulation in Indian Ocean caused by Central American Seaway closure
Authors: Prabhat Priyesh , Rahaman Waliur , Lathika Nambiyathodi , Tarique Mohd , Mishra Ravi , Thamban Meloth 
Published: December 2022

AbstractGlobal overturning circulation underwent significant changes in the late Miocene, driven by tectonic forcing, and impacted the global climate. Prevailing hypotheses related to the late Miocene deep water circulation (DWC) changes driven by the closure of the Central American Seaways (CAS) and its widespread impact remains untested due to the paucity of suitable records away from the CAS region. Here, we test the hypothesis of the large-scale circulation changes by providing a high-resolution record of DWC since the late Miocene (11.3 to ~2 Ma) from the north-western Indian Ocean. Our investigation reveals a progressive shift from Pacific-dominated DWC before ~9.0 Ma to the onset of a modern-like DWC system in the Indian Ocean comprising of Antarctic bottom water and northern component water during the Miocene-Pliocene transition (~6 Ma) caused by progressive shoaling of the CAS and suggests its widespread impact.
Insights into magma ocean dynamics from the transport properties of basaltic melt
Authors: Bajgain Suraj K. , Ashley Aaron Wolfgang , Mookherjee Mainak , Ghosh Dipta B. , Karki Bijaya B. 
Published: December 2022

AbstractThe viscosity of magma plays a crucial role in the dynamics of the Earth: from the crystallization of a magma ocean during its initial stages to modern-day volcanic processes. However, the pressure-dependence behavior of viscosity at high pressure remains controversial. In this study, we report the results of first-principles molecular dynamics simulations of basaltic melt to show that the melt viscosity increases upon compression along each isotherm for the entire lower mantle after showing minima at ~6 GPa. However, elevated temperatures of the magma ocean translate to a narrow range of viscosity, i.e., 0.01–0.03 Pa.s. This low viscosity implies that the crystallization of the magma ocean could be complete within a few million years. These results also suggest that the crystallization of the magma ocean is likely to be fractional, thus supporting the hypothesis that present-day mantle heterogeneities could have been generated during the early crystallization of the primitive mantle.
Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs
Authors: Shen Pei , Chen Lu , Zhang Dahe , Xia Simo , Lv Zhuman , Zou Duohong , Zhang Zhiyuan , Yang Chi , Li Wenlin 
Published: December 2022

AbstractArticular cartilage is highly specific and has limited capacity for regeneration if damaged. Human pluripotent stem cells (hPSCs) have the potential to generate any cell type in the body. Here, we report the dual-phase induction of ectodermal chondrogenic cells (ECCs) from hPSCs through the neural crest (NC). ECCs were able to self-renew long-term (over numerous passages) in a cocktail of growth factors and small molecules. The cells stably expressed cranial neural crest-derived mandibular condylar cartilage markers, such as MSX1, FOXC1 and FOXC2. Compared with chondroprogenitors from iPSCs via the paraxial mesoderm, ECCs had single-cell transcriptome profiles similar to condylar chondrocytes. After the removal of the cocktail sustaining self-renewal, the cells stopped proliferating and differentiated into a homogenous chondrocyte population. Remarkably, after transplantation, this cell lineage was able to form cartilage-like structures resembling mandibular condylar cartilage in vivo. This finding provides a framework to generate self-renewing cranial chondrogenic progenitors, which could be useful for developing cell-based therapy for cranial cartilage injury.
Methylation pattern and mRNA expression of synapse-relevant genes in the MAM model of schizophrenia in the time-course of adolescence
Authors: Khan Abdul Qayyum , Thielen Lukas , Le Pen Gwenaëlle , Krebs Marie-Odile , Kebir Oussama , Groh Adrian , Deest Maximilian , Bleich Stefan , Frieling Helge , Jahn Kirsten 
Published: December 2022

AbstractSchizophrenia is highly heritable and aggregating in families, but genetics alone does not exclusively explain the pathogenesis. Many risk factors, including childhood trauma, viral infections, migration, and the use of cannabis, are associated with schizophrenia. Adolescence seems to be the critical period where symptoms of the disease manifest. This work focuses on studying an epigenetic regulatory mechanism (the role of DNA methylation) and its interaction with mRNA expression during development, with a particular emphasis on adolescence. The presumptions regarding the role of aberrant neurodevelopment in schizophrenia were tested in the Methyl-Azoxy-Methanol (MAM) animal model. MAM treatment induces neurodevelopmental disruptions and behavioral deficits in off-springs of the treated animals reminiscent of those observed in schizophrenia and is thus considered a promising model for studying this pathology. On a gestational day-17, adult pregnant rats were treated with the antimitotic agent MAM. Experimental animals were divided into groups and subgroups according to substance treatment (MAM and vehicle agent [Sham]) and age of analysis (pre-adolescent and post-adolescent). Methylation and mRNA expression analysis of four candidate genes, which are often implicated in schizophrenia, with special emphasis on the Dopamine hypothesis i.e., Dopamine receptor D2 (Drd2), and the “co-factors” Disrupted in schizophrenia 1 (DISC1), Synaptophysin (Syp), and Dystrobrevin-binding protein 1 (Dtnbp1), was performed in the Gyrus cingulum (CING) and prefrontal cortex (PFC). Data were analyzed to observe the effect of substance treatment between groups and the impact of adolescence within-group. We found reduced pre-adolescent expression levels of Drd2 in both brain areas under the application of MAM. The “co-factor genes” did not show high deviations in mRNA expression levels but high alterations of methylation rates under the application of MAM (up to ~20%), which diminished in the further time course, reaching a comparable level like in Sham control animals after adolescence. The pre-adolescent reduction in DRD2 expression might be interpreted as downregulation of the receptor due to hyperdopaminergic signaling from the ventral tegmental area (VTA), eventually even to both investigated brain regions. The notable alterations of methylation rates in the three analyzed co-factor genes might be interpreted as attempt to compensate for the altered dopaminergic neurotransmission.
Salivary secretory leukocyte protease inhibitor levels in patients with stage 3 grade C periodontitis: a comparative cross-sectional study
Authors: Afacan Beral , Öztürk Veli Özgen , Emingil Gülnur , Köse Timur , Mitsakakis Konstantinos , Bostanci Nagihan 
Published: December 2022

AbstractSecretory leukocyte protease inhibitor (SLPI) is an anti-protease that protects mucosal tissue integrity owing to its anti-microbial and immunomodulatory properties. This study aimed to investigate SLPI levels in periodontal diseases, and analyze the potential correlation with clinical periodontal parameters. Whole saliva samples were obtained from healthy (n = 24), gingivitis (n = 24) and patients with stage 3 grade C periodontitis (n = 24). SLPI was measured by ELISA and normalized by total protein. Receiver operating characteristics (ROC) curve was used for estimating the area under the curve (AUC). The normalized SLPI levels were significantly reduced in periodontitis compared with gingivitis (4.84-fold) or health (1.83-fold) and negatively correlated with periodontal parameters. The ROC curves showed a good predictor value of the SLPI for differentiation of periodontitis versus health or gingivitis (AUC ≥ 0.80). This study demonstrates that the levels of SLPI are high in periodontal health, further elevated in gingivitis, but eventually decreased in severe periodontitis beyond the former two states. This observation may have broader implications in the context of inflammatory diseases affecting the oral mucosa, as it shows that the bacterial burden is disturbing the homeostatic balances of anti-microbial and anti-protease factors in the oral cavity.
Parental attachment and emotional intelligence mediates the effect of childhood maltreatment on callous-unemotional traits among incarcerated male adolescents
Authors: Peng Jiaxi , Lu Huijie , Zhang Jiaxi , Yuan Weizhuo , Fang Peng , Tian Jianquan , Wang Lei 
Published: December 2022

AbstractThis study aimed to examine the impact of childhood maltreatment on callous-unemotional (CU) traits among incarcerated male adolescents, focusing primarily on the roles of parental attachment and emotional intelligence. A total of 454 male incarcerated adolescents from two juvenile correctional facilities, ranging in age from 14 to 18 years, completed a set of questionnaires consisting of a childhood trauma questionnaire, parent-attachment scale, emotional intelligence scale, and the Inventory of CU traits. The results revealed that childhood maltreatment, parental attachment, and emotional intelligence were all correlated with CU traits. Structural equation modeling analysis and the bootstrap test indicated that parental attachment and emotional intelligence mediated, in part, the effect of childhood maltreatment on CU traits. These findings expand the outcomes of previous research and shed light on how childhood maltreatment is related to CU traits.
Spatial energy density of large-scale electricity generation from power sources worldwide
Authors: Nøland Jonas Kristiansen , Auxepaules Juliette , Rousset Antoine , Perney Benjamin , Falletti Guillaume 
Published: December 2022

AbstractThis paper introduces the annual energy density concept for electric power generation, which is proposed as an informative metric to capture the impacts on the environmental footprint. Our investigation covers a wide range of sources classified by rated power and compares different regions to establish typical spatial flows of energy and evaluate the corresponding scalability to meet future net-zero emission (NZE) goals. Our analysis is conducted based on publicly available information pertaining to different regions and remote satellite image data. The results of our systematic analysis indicate that the spatial extent of electric power generation toward 2050 will increase approximately sixfold, from approximately 0.5% to nearly 3.0% of the world’s land area, based on International Energy Agency (IEA) NZE 2050 targets. We investigate the worldwide energy density for ten types of power generation facilities, two involving nonrenewable sources (i.e., nuclear power and natural gas) and eight involving renewable sources (i.e., hydropower, concentrated solar power (CSP), solar photovoltaic (PV) power, onshore wind power, geothermal power, offshore wind power, tidal power, and wave power). In total, our study covers 870 electric power plants worldwide, where not only the energy density but also the resulting land or sea area requirements to power the world are estimated. Based on the provided meta-analysis results, this paper challenges the common notion that solar power is the most energy-dense renewable fuel source by demonstrating that hydropower supersedes solar power in terms of land use in certain regions of the world, depending on the topography.
Observational database study on preeclampsia and postpartum medical care up to 7.5 years after birth
Authors: Scholz Anna S. , Hassdenteufel Kathrin , Gutsfeld Raphael , Müller Mitho , Goetz Maren , Bauer Armin , Wallwiener Markus , Brucker Sara Y. , Joos Stefanie , Colombo Miriam Giovanna , Hawighorst‑Knapstein Sabine , Chaudhuri Ariane , Beck Frauke , Wallwiener Stephanie 
Published: December 2022

AbstractPreeclampsia is associated with a substantially increased long-term risk for cardiovascular, cerebrovascular and renal disease. It remains unclear whether and to which extent specialized medical postpartum care is sought. We aimed to assess current utilization of postpartum primary and specialized care and medication prescription behavior in women who experienced preeclampsia. This retrospective observational study based on statutory claims data included 193,205 women with 258,344 singleton live births between 2010 and 2017 in Southern Germany. Postpartum care was evaluated by analyzing and comparing the frequency of medical consultations in primary and specialized care and prescriptions for antihypertensive medication among women with and without preeclampsia up to 7.5 years after delivery. Gynecologists and general practitioners were the main health care providers for all women. Although specialized postpartum care was sought by more women after preeclampsia, the effect size indices revealed no considerable association between a history of preeclampsia and the utilization of specialized outpatient aftercare (e.g. 2% vs. 0.6% of patients with and without preeclampsia who consulted a nephrologist during the first year postpartum, r = 0.042). Preeclampsia was associated with an increased risk to take any antihypertensive medication after delivery (HR 2.7 [2.6; 2.8]). Postpartum referral to specialized outpatient care and quarterly prescriptions of antihypertensives following preeclampsia failed to match the early and rapidly increased incidence and risk of hypertension. These data highlight the missed opportunity to implement a reasonable follow-up strategy and prevention management in order to achieve long-term clinical benefits.
Effective adjuvantation of nanograms of influenza vaccine and induction of cross-protective immunity by physical radiofrequency adjuvant
Authors: Li Zhuofan , Kang Xinliang , Kim Ki-Hye , Zhao Yiwen , Li Yibo , Kang Sang-Moo , Chen Xinyuan 
Published: December 2022

AbstractNovel adjuvants are highly demanded to aid in development of improved or new vaccines against existing or emerging infectious diseases. Considering commonly used Alum and MF59 adjuvants induce tissue stress and release of endogenous danger signals to mediate their adjuvant effects, physical modalities may be used to induce tissue stress and endogenous danger signal release to enhance vaccine-induced immune responses. Furthermore, physical adjuvants are less likely to induce significant systemic adverse reactions due to their localized effects. Recently we found non-invasive radiofrequency (RF) pretreatment of the skin could significantly enhance intradermal vaccine-induced immune responses in murine models that included pandemic influenza vaccine, pre-pandemic vaccine, and influenza internal antigen vaccine. It remained to be explored whether the physical RF adjuvant (RFA) could be used to boost seasonal influenza vaccination, spare vaccine doses, and induce cross-protective immunity. This study found the physical RFA could significantly enhance seasonal influenza vaccine-induced immune responses against each viral strain and robustly enhance low-dose (nanograms) H3N2 vaccine-induced immune responses and protection in murine models. RFA also induced cross-protective immunity against heterologous and heterosubtypic influenza viruses. Further studies found heat shock protein 70 (inducible endogenous danger signal) and myeloid differentiation primary response 88 adaptor played a crucial role in dose-sparing effects of RFA. These data strongly support further development of the physical RFA to boost influenza vaccination.
LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation
Authors: Gao Haibing , Wang Xiangmei , Ma Huaxi , Lin Shenglong , Zhang Dongqing , Wu Wenjun , Liao Ziyuan , Chen Mengyun , Ye Hanhui , Li Qin , Lin Minghua , Li Dongliang 
Published: December 2022

AbstractmiR-34a targeting on Smad4 plays important role in TGF-β1 pathway which is a dominant factor for balancing collagen production and degradation in hepatic stellate cells. TGF-β1/Smad4 regulated collagen deposition is a hallmark of hepatic fibrosis. The potential regulation on miR-34a by LncRNAs in hepatic stellate cells (HSCs) is still reserved to be revealed. In current study, it was hypothesized that a miR-34a interactor, lncRNA CCAT2 may regulate TGF-β1 pathway in liver fibrotic remodeling. The interaction between CCAT2 and miR-34a-5p was checked by dual luciferase assay. the effects of CCAT2 and miR-34a-5p on cell proliferation and apoptosis were verified by MTT assay, colony formation assay, and flow cytometry assay. Dual luciferase activity showed CCAT2 are targets of miR-34a-5p. Sh-CCAT2 transfection prohibit HSCs proliferation and induce HSCs apoptosis, also inhibited ECM protein synthesis in HSCs. Decreased miR-34a-5p enhanced HSCs proliferation, blocked HSCs apoptosis and promoted ECM protein production. miR-34a-5p inhibitor undo protective regulation of sh-CCAT2 in liver fibrosis. Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum. In conclusion, activated HSCs via TGF-β1/Smad4 signaling pathway was successfully alleviated by CCAT2 inhibition through miR-34a-5p elevation.
Effects of supplementation of pomegranate processing by-products and waste cooking oils as alternative feed resources in broiler nutrition
Authors: Ghasemi-Sadabadi Mohammad , Ebrahimnezhad Yahya , Maheri-Sis Naser , Shaddel-Teli Abdolahad , Ghalehkandi Jamshid Ghiasi , Veldkamp Teun 
Published: December 2022

AbstractAgricultural residues can be used as alternative feed sources in industrial chicken production. The impacts of different levels of pomegranate peel and waste cooking oil as an agricultural residue on broilers' nutrition were investigated. Results showed that the replacement of 8% pomegranate peel in diets decreased the growth performance of broilers. Supplementing 8% pomegranate peel in diets reduced apparent nutrient digestibility. The highest level of waste oil inclusion in broiler diets indicated negative impacts on apparent zmetabolizable energy and crude fat apparent nutrients digestibility. Broilers fed the diet containing 4% pomegranate peel had a higher Lactobacillus population. The results showed that the Lactobacillus population was lower in broilers fed 8% pomegranate peel powder and 4% waste oil in diets. The inclusion of 8% pomegranate peel powder in diets showed lower villus height and crypt depth in the duodenum, jejunum, and ileum. The inclusion of 4% pomegranate peel decreased the peroxide value (PV) of meat. Dietary inclusion of 4% waste oil raised the PV of meat. Alpha-tocopherol supplementation decreased the PV of meat. Finally, the results provide information that 4% of pomegranate peel and 4% waste oil could be used as an alternative feed ingredient in broiler diets without adverse effects.