bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lurasidone‐induced hyperosmolar hyperglycemic syndrome: A case report
Authors: Hanyu Shota , Kojima Yusuke , Murai Toshiya , Kawashima Hirotsugu 
Published: May 2022

AbstractIntroductionLurasidone has few metabolic adverse effects and is recommended as an alternative when other antipsychotic drugs considerably increase body weight or blood sugar concentrations.Case presentationAn 81‐year‐old man with bipolar disorder developed hyperosmolar hyperglycemic syndrome as a side effect of lurasidone. Routine monitoring of blood glucose concentrations led to the early detection and treatment of this disease, preventing life‐threatening complications.Discussion and conclusionWe describe a rare case of lurasidone‐induced hyperosmolar hyperglycemic syndrome. The mortality rate of this syndrome is estimated to be up to 20%. This rate is significantly higher than that of diabetic ketoacidosis (currently <2%). Although lurasidone is considered to have a low risk of raising blood glucose concentrations, symptoms of hyperglycemia must be evaluated and blood glucose concentrations should be monitored regularly.
Retroviral lineage analysis reveals dual contribution from ectodermal placodes and neural crest cells to avian olfactory sensory and GnRH neurons
Authors: Koontz Alison , Urrutia Hugo A. , Bronner Marianne E. 
Published: May 2022

AbstractThe origin of the neurons and glia in the olfactory system of vertebrates has been controversial, with different cell types attributed to being of ectodermal placode versus neural crest lineage, depending upon the species. Here, we use replication incompetent avian retroviruses to perform a prospective cell lineage analysis of either presumptive olfactory placode or neural crest cells during early development of the chick embryo. Surprisingly, the results reveal a dual contribution from both the olfactory placode and neural crest cells to sensory neurons in the nose and gonadotropin‐releasing hormone neurons migrating to the olfactory bulb. We also confirm that olfactory ensheathing glia cells are solely derived from the neural crest. Finally, our results show that neural crest cells and olfactory placode cells contribute to p63 positive cells, likely to be basal stem cells of the olfactory epithelium. Taken together, these finding provide evidence for previously unknown contributions of neural crest cells to some cell types in the chick olfactory system and help resolve previous discrepancies in the literature.Key Points
Modified retroviruses were used to permanently label progenitor cells of the neural crest and olfactory placode for the long‐term lineage analysis of olfactory cells.

Both neural crest cells and olfactory placode cells contribute to olfactory neurons and supporting cells of the olfactory epithelium.

The gonadotropin‐releasing hormone neurons that arise in the nose and migrate toward the hypothalamus during development also receive contributions from both neural crest and placode cells.
Obesity accelerates acute promyelocytic leukemia in mice and reduces sex differences in latency and penetrance
Authors: Kincaid John W. R. , Weiss Gretchen , Hill‐Baskin Anne E. , Schmidt Heidi M. , Omoijuanfo Ovwoioise , Thompson Cheryl L. , Beck Rose C. , Berger Nathan A. 
Published: May 2022

AbstractObjectiveObesity has emerged as a prominent risk factor for multiple serious disease states, including a variety of cancers, and is increasingly recognized as a primary contributor to preventable cancer risk. However, few studies of leukemia have been conducted in animal models of obesity. This study sought to characterize the impact of obesity, diet, and sex in a murine model of acute promyelocytic leukemia (APL).MethodsMale and female C57BL/6J.mCG+/PR mice, genetically predisposed to sporadic APL development, and C57BL/6J (wild type) mice were placed on either a high‐fat diet (HFD) or a low‐fat diet (LFD) for up to 500 days.ResultsRelative to LFD‐fed mice, HFD‐fed animals displayed increased disease penetrance and shortened disease latency as indicated by accelerated disease onset. In addition, a diet‐responsive sex difference in APL penetrance and incidence was identified, with LFD‐fed male animals displaying increased penetrance and shortened latency relative to female counterparts. In contrast, both HFD‐fed male and female mice displayed 100% disease penetrance and insignificant differences in disease latency, indicating that the sexual dimorphism was reduced through HFD feeding.ConclusionsObesity and obesogenic diet promote the development of APL in vivo, reducing sexual dimorphisms in disease latency and penetrance.
In Silico Design and SAR Study of Dibenzyl Trisulfide Analogues for Improved CYP1A1 Inhibition
Authors: Clarke Nishani , Irvine William 
Published: May 2022

AbstractDibenzyl trisulfide (DTS) is a natural compound with potential cancer‐preventive properties occurring inPetiveria alliaceaL., an ethnomedicinal plant native to the Americas. Previous studies revealed its inhibitory activity toward cytochrome P450 (CYP)1 enzymes, key in the activation of environmental pollutants. Accordingly, the aim of this study was to design novel DTS analogues, aimed at improving not only inhibitory activity, but also specificity toward CYP1A1. This was achieved by targeting interactions with CYP1A1 residues of identified importance. Three‐dimensional structures for the novel analogues were subjected to molecular docking with several CYP isoforms, before being ranked in terms of binding affinity to CYP1A1. With three hydrogen bond donors, two hydrogen bond acceptors, a molecular mass of 361 Da, and a log Pof 3.72, the most promising DTS analogue obeys Lipinski's rule of five. Following synthesis and in vitro validation of its CYP1A1‐inhibitory properties, this compound may be useful in future cancer‐preventive approaches.
Genetic loci associated with freezing tolerance in a European rapeseed (Brassica napus L.) diversity panel identified by genome‐wide association mapping
Authors: Chao Wun S. , Li Xuehui , Horvath David P. , Anderson James V. 
Published: May 2022

AbstractWinter biotypes of rapeseed (Brassica napus L.) require a vernalization treatment to enter the reproductive phase and generally produce greater yields than spring rapeseed. To find genetic loci associated with freezing tolerance in rapeseed, we first performed genotyping‐by‐sequencing (GBS) on a diversity panel consisting of 222 rapeseed accessions originating primarily from Europe, which identified 69,554 high‐quality single‐nucleotide polymorphisms (SNPs). Model‐based cluster analysis suggested that there were eight subgroups. The diversity panel was then phenotyped for freezing survival (visual damage and Fv/Fo and Fv/Fm) after 2 months of cold acclimation (5°C) and a freezing treatment (−15°C for 4 h). The genotypic and phenotypic data for each accession in the rapeseed diversity panel was then used to conduct a genome‐wide association study (GWAS). GWAS results showed that 14 significant markers were mapped to seven chromosomes for the phenotypes scored. Twenty‐four candidate genes located within the mapped loci were identified as previously associated with lipid, photosynthesis, flowering, ubiquitination, and cytochrome P450 in rapeseed or other plant species.
A non‐chemical weed control strategy, introducing duckweed into the paddy field
Authors: Wang Feng , Wang Shuang , Xu Shuhan , Shen Jianying , Cao Linkui , Sha Zhimin , Chu Qingnan 
Published: May 2022

AbstractBACKGROUNDHerbicide resistance in weeds and environmental pollution resulting from excessive application of chemical herbicides keeps increasing. Development of environment‐friendly and effective weed management strategies are required for sustainable agricultural production. In this study we investigated the effects of duckweeds (Landoltia punctata (G. Meyer) Les & D. J. Crawford and Spirodela polyrhiza (Linnaeus) Schle iden) introduction on the weed community and rice growth in paddy fields.RESULTSThe study was conducted in the two rice‐growing seasons (2018 and 2019) with three treatments: rice grown without duckweed introduction (CK), with L. punctata introduction (LP), and with S. polyrhiza introduction (SP). On average, LP and SP significantly reduced total weed density by more than 90% and 97%, respectively. Early in the rice‐growing season, both duckweed species completely prevented weed growth. Further, both species significantly promoted rice plant growth in the advanced stages. SP significantly improved grain yield of rice by 23%. Light transmittance, temperature of the floodwater and soil, floodwater pH, and dissolved oxygen content significantly decreased following introduction of the duckweeds, indicating that the duckweeds introduction might inhibit weeds growth by altering environmental factors.CONCLUSIONThis study provides a possible environment‐friendly way to inhibit weed biomass in the paddy field by introducing duckweeds and interpreted the possible reasons of the impacts of duckweed on environmental variables. Weed control is beneficial for rice growth. Duckweed coverage might be limited in open fields and the associated practice requires additional investigation. © 2022 Society of Chemical Industry.
Insights into the genetic spatial structure of Nicaraguan weedy rice and control of its seed spread
Authors: Hsu Wei‐Chun , Wu Dong‐Hong , Chen Szu‐Wu , Castillo Sergio Antonio Cuadra , Huang Sih‐Dun , Li Charng‐Pei , Wang Yun‐Ping 
Published: May 2022

AbstractBACKGROUNDThe genetic backgrounds and occurrence patterns of weedy rice (WR, Oryza sativa) are highly diverse, and so are the challenges facing its control among countries. WR control is difficult because it is similar to cultivated rice and manual removal is one of the few options for control. Understanding the ecology of WR will aid efforts to break its life cycle and establish long‐term management strategies under both irrigated and rainfed systems.RESULTSNicaraguan WR (NWR) plants were genetically closer to the AUS and Indica pools in terms of to genetic distance. A map of admixture coefficients suggested a pattern of long‐distance dispersal and spread of NWR across Nicaragua, which has likely been facilitated by commercial activities and sharing of harvesting equipment between border cities or important trading ports and inland regions. Moreover, the NWR plants from the soil seedbank in irrigated regions showed different habitats and lower grain number per panicle compared with plants spread by seed‐mediated contamination. In addition, grain indexes showed that length‐to‐width ratio was a better indicator than awn length for distinguishing between NWR and Nicaraguan Indica cultivars.CONCLUSIONAnalysis of the population structure and habitats of NWR revealed five clusters derived from seed‐mediated contamination in rainfed upland regions, plants from the soil seedbank in irrigated double‐cropping regions, and pollen‐mediated contamination across both regions. Field weed management before harvesting and seed purification based on the length‐to‐width ratio can be conducted to improve the efficiency of long‐term control of WR in Nicaragua. © 2022 Society of Chemical Industry.
A new evolutionism based self‐adaptive multi‐objective optimization method to predict software cost estimation
Authors: Gouda Sunil Kumar , Mehta Ashok Kumar 
Published: May 2022

AbstractOne of the major challenge that organizations face in the present environment is having an efficient model for software cost estimation (SCE). In this article, the significance of the meta‐heuristic algorithm in addressing various optimization challenges faced in mathematical models and software applications is discussed. The proposed method uses the new evolutionism‐based self‐adaptive mutation operator to solve the multi‐objective optimization problems. This approach addresses the issues that exist in multi‐objective differential evolution algorithms. To improve diversity among candidate solutions, the Pareto optimality principle is integrated with the evolutionism‐based self‐adaptive mutation operator in a multi‐objective DE algorithm. To reduce the time complexity of Pareto dominance, we have adopted the non‐dominated sorting algorithm. We used eight benchmark test functions to evaluate the effectiveness of the proposed method, and it outperformed the most recent multi‐objective evolutionary algorithms (MOEAs). Furthermore, this article explores software engineering problems like SCE by using the proposed approach, where SCEs are accurately predicted by optimizing the tuning parameters of the multi‐objective constructive cost model. The proposed algorithm achieves better cost prediction as compared to the other standard benchmark algorithms for all objective problems in terms of prediction, mean absolute error, and root mean square error.
Development and validation of an optimized marker set for genomic selection in southern U.S. rice breeding programs
Authors: Cerioli Tommaso , Hernandez Christopher O. , Angira Brijesh , McCouch Susan R. , Robbins Kelly R. , Famoso Adam N. 
Published: May 2022

AbstractThe potential of genomic selection (GS) to increase the efficiency of breeding programs has been clearly demonstrated; however, the implementation of GS in rice (Oryza sativa L.) breeding programs has been limited. In recent years, efforts have begun to work toward implementing GS into the Louisiana State University (LSU) Agricultural Center rice breeding program. One of the first steps for successful GS implementation is to establish a suitable marker set for the target germplasm and a reliable, cost‐effective genotyping platform capable of providing informative marker data with an adequate turnaround time. The objective of this study was to develop a marker set for routine GS and demonstrate its effectiveness in southern U.S. rice germplasm. The utility of the resulting marker set, the LSU500, for GS applications was demonstrated using four years of breeding data across 7,607 experimental lines and four elite biparental populations. The predictive ability of GS ranged from 0.13 to 0.78 for key traits across different market classes and yield trials. Comparisons between phenotypic selection and GS within biparental populations demonstrates similar performance of GS compared with phenotypic selection in predicting future performance. The prediction accuracies obtained with the LSU500 marker set demonstrates the utility of this marker set for cost‐effective GS applications in southern U.S. rice breeding programs. The LSU500 marker set has been established through the genotyping service provider Agriplex Genomics, and in the future, it will undergo improvements to reduce the cost and increase the accuracy of GS.
Analgesic comparison between topical irrigation (splash block) versus injection of lidocaine on the ovarian pedicle in canine ovariectomy
Authors: Cicirelli Vincenzo , Lacalandra Giovanni Michele , Cseh Sandor , Mrenoshki Daniela , Lillo Edoardo , Bianchi Francesco Paolo , Aiudi Giulio Guido 
Published: May 2022

AbstractObjectivesThe aim of this study was to compare the analgesic efficacy of topical irrigation versus injection of lidocaine on the ovarian pedicle to provide analgesia in bitches ovariectomy. In the current study were monitored: increased blood pressure, heart rate and respiratory rate to identify an acute intraoperative nociceptive response. These parameters were registered at six times during the surgical procedure: grasping of the ovary (time 1), dissection of the mesosalpinx (time 2), tightening of the first loop ligature (time 3), tightening of the second loop ligature (time 4), transection of the ovarian pedicle (time 5) and release of the ovary (time 6).Material and MethodsForty healthy bitches were randomly assigned in two groups (n = 20) to receive topical irrigation (splash block) of 2% lidocaine (C group) on both ovarian pedicle (2 mg/kg each), or an equal volume of lidocaine was injected at the same sites (R group).ResultsThe results of the present study suggest that splash block may provide intraoperative analgesic effects equivalent to injection in the ovarian pedicle in dogs that have undergone ovariectomy. The lidocaine improved surgical analgesia during canine ovariectomy in both groups, and this action is not affected by the inoculation technique.Clinical significancePain management in veterinary patients is a crucial component of appropriate patient care. Therefore, the need for achieving safer anaesthesia for surgical intervention is gaining much attention. Ovariectomy is a common surgical procedure in bitches with medium level of pain. This study concluded that considering its relative simplicity, low cost, and safety, both techniques could be used in daily clinical practice.
Aktualisierte Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland (Stand 30. März 2022), angemeldet als S1-Leitlinie (AWMF-Register Nr. 048-017)
Authors: Pfeil Johannes ,   DGPI, Bialek Ralf , Heininger Ulrich , Liese Johannes , Simon Arne , Stich August , Assaad Kholoud ,   BVÖGD, von Both Ulrich ,   DAKJ/Bündnis Kinder- und Jugendgesundheit, Janda Aleš , Kitz Christa , Kobbe Robin ,   GTP, Kunze Mirjam ,   DGGG, Lindert Judith ,   DGKCH, Ritz Nicole ,   PIGS, Trapp Stefan ,   BVKJ, Fressle Roland , Hufnagel Markus ,   DGKJ
Published: May 2022

ZusammenfassungHintergrundMit etwa 190.000 Asylanträgen im Jahr 2021 ist Deutschland das wichtigste Aufnahmeland von Asylsuchenden in Europa.Die vorliegenden Handlungsempfehlungen sollen eine Grundlage für eine evidenzbasierte und zielgerichtete infektiologische Versorgung minderjähriger Flüchtlinge schaffen.ZieleDie Handlungsempfehlungen sollen medizinisches Personal in der Versorgung minderjähriger Flüchtlinge unterstützen, um1. einen unvollständigen Impfschutz frühzeitig zu erkennen und zu vervollständigen;2. übliche Infektionskrankheiten zu diagnostizieren und zu behandeln;3. in Deutschland seltene Infektionskrankheiten frühzeitig zu erkennen und zu therapieren.Material und MethodenDie Handlungsempfehlungen wurden als AWMF-Leitlinie Stufe 1 verfasst.Entsprechend wurden die Empfehlungen durch eine repräsentativ zusammengesetzte Expertengruppe der beteiligten Fachgesellschaften im informellen Konsens erarbeitet und final von den Vorständen der Fachgesellschaften offiziell verabschiedet.ErgebnisseEs werden Empfehlungen ausgesprochen, für den Umfang der Anamnese und der körperlichen Untersuchung minderjähriger Flüchtlinge. Für alle minderjährigen Flüchtlinge werden die Bestimmung eines Differenzialblutbildes sowie Untersuchungen auf Tuberkulose und Hepatitis B empfohlen.Je nach Herkunft und Alter werden weitere gezielte Untersuchungen z. B. auf Hepatitis C, HIV oder Schistosomiasis empfohlen. Zur raschen Vervollständigung des Impfstatus wird eine alters- und indikationsbezogene Priorisierung einzelner Impfungen vorgenommen.DiskussionAngesichts anhaltend hoher Flüchtlingszahlen ist eine weitere Professionalisierung der medizinischen Versorgung minderjähriger Flüchtlinge notwendig. Hierzu sollten die notwendigen strukturellen und personellen Rahmenbedingungen geschaffen werden.
Keratitis durch Fusarien – eine zunehmende Bedrohung in Deutschland?
Authors: Kovalchuk Bogdana , Khoramnia Ramin , Tóth Marcell , Horner Susanne , Auffarth Gerd U. , Augustin Victor A. 
Published: May 2022

Zusammenfassung
Hintergrund
Galt die mykotische Keratitis durch Fusarien in Industrienationen bisher als Seltenheit, so ist in den letzten Jahren ein Anstieg der Fusarien-Keratitiden auch in Deutschland zu verzeichnen. Anhand der folgenden Studie möchten wir gegenüber dem klinischen Krankheitsbild sensibilisieren sowie diagnostische und therapeutische Möglichkeiten aufzeigen.

Methodik
In dieser monozentrischen, retrospektiven Fallserie wurden alle Patienten der Universitäts-Augenklinik Heidelberg im Zeitraum von 2011 bis 2021 eingeschlossen, bei denen ein mikrobiologischer Nachweis von Fusarium Spezies gelang.

Ergebnisse
Insgesamt 13 Fälle mit mikrobiologischem Nachweis von Fusarium Spezies konnten identifiziert werden, auffällig war eine Häufung im Jahr 2021. Die Patienten waren zu 76,9 % weiblich und zu 76,9 % Kontaktlinsenträger. Nur in 4 Fällen gelang die Erregeridentifizierung aus dem initialen Hornhautabradat. Die durchschnittliche Dauer bis zur Verdachtsdiagnose einer mykotischen Genese betrug 13,1 Tage, die mittlere Dauer bis zum Erregernachweis 14,6 Tage ab Symptombeginn. Alle getesteten Erreger wiesen Resistenzen gegen mindestens ein gängiges Antimykotikum auf. Die Therapie mittels perforierender Keratoplastik war bei 70 % der Fälle erforderlich, in 57,1 % kam es dabei zu einem Rezidiv. In 80 % betrug der beste dokumentierte Visus nach Fusarien-Keratitis in unserer Fallserie ≤ 0,4.

Schlussfolgerung
Bei erschwerten Nachweismöglichkeiten und hoher Resistenzlage kommt es bei der Fusarien-Keratitis meist zu einem verspäteten Therapiebeginn mit reduzierter Visusprognose. Bei Vorliegen von Risikofaktoren und Nicht-Ansprechen auf Antibiotika muss frühzeitig eine antimykotische Therapie eingeleitet und ggf. eine Keratoplastik erwogen werden.
Implementation of prehabilitation in colorectal cancer surgery: qualitative research on how to strengthen facilitators and overcome barriers
Authors: Heil Thea C. , Driessen Elisabeth J. M. , Argillander Tanja E. , Melis René J. F. , Maas Huub A. A. M. , Olde Rikkert Marcel G. M. , de Wilt Johannes H. W. , van Munster Barbara C. , Perry Marieke 
Published: May 2022

Abstract
Purpose
Prehabilitation is increasingly offered to patients with colorectal cancer (CRC) undergoing surgery as it could prevent complications and facilitate recovery. However, implementation of such a complex multidisciplinary intervention is challenging. This study aims to explore perspectives of professionals involved in prehabilitation to gain understanding of barriers or facilitators to its implementation and to identify strategies to successful operationalization of prehabilitation.

Methods
In this qualitative study, semi-structured interviews were performed with healthcare professionals involved in prehabilitation for patients with CRC. Prehabilitation was defined as a preoperative program with the aim of improving physical fitness and nutritional status. Parallel with data collection, open coding was applied to the transcribed interviews. The Ottawa Model of Research Use (OMRU) framework, a comprehensive interdisciplinary model guide to promote implementation of research findings into healthcare practice, was used to categorize obtained codes and structure the barriers and facilitators into relevant themes for change.

Results
Thirteen interviews were conducted. Important barriers were the conflicting scientific evidence on (cost-)effectiveness of prehabilitation, the current inability to offer a personalized prehabilitation program, the complex logistic organization of the program, and the unawareness of (the importance of) a prehabilitation program among healthcare professionals and patients. Relevant facilitators were availability of program coordinators, availability of physician leadership, and involving skeptical colleagues in the implementation process from the start.

Conclusions
Important barriers to prehabilitation implementation are mainly related to the intervention being complex, relatively unknown and only evaluated in a research setting. Therefore, physicians’ leadership is needed to transform care towards more integration of personalized prehabilitation programs.

Implications for cancer survivors
By strengthening prehabilitation programs and evidence of their efficacy using these recommendations, it should be possible to enhance both the pre- and postoperative quality of life for colorectal cancer patients during survivorship.