bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact Artificial Intelligence in the Pharmaceutical Industry on Working Culture: A Review
Authors: Lodhi Devendra Singh , Verma Megha , Golani Pradeep , Pawar Akash Singh , Nagdev Sanjay 
Published: February 2022

The pharmaceutical and healthcare industries have benefited greatly from artificial intelligence in recent years. A wide range of pharmaceutical fields, such as this novel approach, showed potential in drug discovery, continuous manufacturing (CM), dosage form design, and quality control. This article focuses on the use of artificial intelligence in the pharmaceutical sector. Before all else, the film sheds light on how AI will be implemented into health care, as well as its potential benefits. To conclude, there are several hurdles to overcome in the project implementation. At present, it's no secret that artificial intelligence (AI) and genetic algorithms (ANNs) are becoming increasingly popular in the pharmaceutical industry. In the pharmaceutical industry, artificial intelligence (AI) has shown promise, and it can be used in combination with robotics. Physical robots could revolutionize the healthcare industry. To keep their minds sharp and alert, it's used as a social interaction guide with elderly patients. In the pharmaceutical industry, artificial intelligence (AI) will help reduce costs and time.
Cancer of the oral mucosa (cancer of the tongue, floor of mouth, lower jaw, cheek)/lip: modern therapeutic technologies
Authors: Solodkii Vladimir , Panshin Georgii , Petrovskii Vladimir , Izmailov Timur , Titova Вера 
Published: February 2022

Purpose. Evaluation of the effectiveness of three treatment options for cancer oral mucosa (cancer of the tongue and floor of mouth, cheek, lower jaw)/lip (OC/lip).
Materials and methods. Treated 100 patients with OC/lip: combined treatment with surgery at the first stage and postoperative conformal external beam radiation therapy (EBRT) of 50 Gy — 40 patients; combined conformal EBRT and brachytherapy (BT HDR) — 40 patients; EBRT and photodynamic therapy (PDT) with intensive laser hyperthermia — 20 patients. The age of the patients ranged from 26 to 90 years; among them were 55 men and 45 women.
Results. Five-year overall survival (OS) and relapse-free survival (RFS) in patients with tumors of various localization was 88% and 73.3% respectively with a good quality of life. Five-year OS was for combined method of treatment — 82,8%; combined EBRT and brachytherapy — 94,4% and EBRT in combination with PDT and laser hyperthermia — 83,3% (р=0,561). With tumors of stage I–II, the five-year OS was 94.4% and III–IV stage — decreased to 73.1% with a high level of statistical significance of the χ²=6.042, p=0.014.
Conclusions. OC and lip cancer is most effectively cured in the I–II stage of the disease with the initial implementation of the surgical stage preceding EBRT. EBRT with photodynamic therapy and laser hyperthermia is effective for contraindications for patients to brachytherapy. The determination of PM (predictive markers) is a promising direction in optimizing the antitumor treatment of malignant neoplasms of OC/lip.
Levels of steroid hormones, their receptors, prolactin and SSBG in tissues of patients with gastric cancer
Authors: Kit Oleg , Frantsiyants Elena , Kaplieva Irina , Bandovkina Valeria , Gevorkyan Yuriy , Soldatkina Natalia , Dzhenkova Elena , Cheryarina Natalia , Goroshinskaya Irina , Samoilenko Nikolay , Shaposhnikov Aleksandr , Sidorenko Yuriy 
Published: February 2022

Background. Hormones and their receptors are important effectors providing interconnection between the primary tumor and metastatic niches.
The aim of the study was to determine levels of prolactin (PRL), sex steroid binding globulin (SSBG), steroid hormones and their receptors in tissues of gastric cancer (GC), omentum and peritoneum.
Materials and methods. Levels of PRL, SSBG, steroid hormones and their receptors were determined by ELISA in tissues of primary tumors, omentum and peritoneum in main groups: 1 (M0) — GC T3–4аN0–3M0 (n=24) and 2 (M1) — GC T3–4аN0–3M1 (n=21); in tissues of the stomach, omentum and peritoneum — in the comparison group — non-cancer patients (n=17).
Results. GC (М0) was characterized by high levels of estrogen receptors (ER) α — by 1.2 times (p<0.05), progesterone (PR) — by 3.5 times and SSBG — by 1.4 times (p<0.05); tissues of the omentum and peritoneum showed increased levels of ERα — by 2.4 and 3.9 times, ERβ — by 1.5 (p<0.05) and 2.5 times, РR — by 2.2 and 1.5 times (p<0.05). GC (М1) had low ERα levels; in tissues of GC, omentum and peritoneum, estradiol was reduced — by 4.2, 4.0 and 8.6 times, respectively, free testosterone increased — by 18.9, 2.0 and 2.8 times, and PRL increased by 8.0, 7.6 and 1.7 times (p<0.05).
Conclusions. Elevated levels of receptors ERα, ERβ and РR in metastatic niches in GC can be considered one of the factors protecting tissues from metastatic colonization, and levels of ERα and РR in the niches correlate with their levels in tumor tissues in GC М1 and М0.
Searching for Stellar and Planetary Emission in Large Field-of-view Radio Sky Surveys
Authors: Ling Jason , Isella Andrea , Johns-Krull Christopher , W. Lazio T. Joseph 
Published: February 2022

Abstract
Detection of low-frequency (≤1.4 GHz) radio emission from stellar and planetary systems can lead to new insights into stellar activity, extrasolar space weather, and planetary magnetic fields. In this work, we investigate three large field-of-view surveys at 74 MHz, 150 MHz, and 1.4 GHz, as well as a myriad of multiwavelength ancillary data, to search for radio emission from about 2600 stellar objects, including about 800 exoplanetary systems, 600 nearby low-mass stars, and 1200 young stellar objects located in the Taurus and Upper Scorpius star-forming regions. The selected sample encompasses stellar spectral types from B to L and distances between 5 and 300 pc. We report the redetection of five stars at 1.4 GHz, one of which also shows emission at 150 MHz. Four of these are low- and intermediate-mass young stars, and one is the evolved star α Sco. We also observe radio emission at the position of a young brown dwarf at 1.4 GHz and 150 MHz. However, due to the large astrometric uncertainty of radio observations, a follow-up study at higher angular resolution would be required to confirm whether the observed emission originates from the brown dwarf itself or a background object. Notably, all of the selected radio sources are located in nearby star-forming regions. Furthermore, we use image stacking and statistical methods to derive upper limits on the average quiescent radio luminosity of the families of objects under investigation. These analyses provide observational constraints for large-scale searches for current and ongoing low-frequency radio emissions from stars and planets.
The Sloan Digital Sky Survey Reverberation Mapping Project: UV–Optical Accretion Disk Measurements with the Hubble Space Telescope
Authors: Homayouni Y. , Sturm Megan R. , Trump Jonathan R. , Horne Keith , Grier C. J. , Shen Yue , Brandt W. N. , Alvarez Gloria Fonseca , Hall P. B. , Ho Luis C. , Li Jennifer I-Hsiu , Sun Mouyuan , Schneider D. P. 
Published: February 2022

Abstract
We present accretion-disk structure measurements from UV–optical reverberation mapping (RM) observations of a sample of eight quasars at 0.24 < z < 0.85. Ultraviolet photometry comes from two cycles of Hubble Space Telescope monitoring, accompanied by multiband optical monitoring by the Las Cumbres Observatory network and Liverpool Telescopes. The targets were selected from the Sloan Digital Sky Survey Reverberation Mapping project sample with reliable black hole mass measurements from Hβ RM results. We measure significant lags between the UV and various optical griz bands using JAVELIN and CREAM methods. We use the significant lag results from both methods to fit the accretion-disk structure using a Markov Chain Monte Carlo approach. We study the accretion disk as a function of disk normalization, temperature scaling, and efficiency. We find direct evidence for diffuse nebular emission from Balmer and Fe ii lines over discrete wavelength ranges. We also find that our best-fit disk color profile is broadly consistent with the Shakura & Sunyaev disk model. We compare our UV–optical lags to the disk sizes inferred from optical–optical lags of the same quasars and find that our results are consistent with these quasars being drawn from a limited high-lag subset of the broader population. Our results are therefore broadly consistent with models that suggest longer disk lags in a subset of quasars, for example, due to a nonzero size of the ionizing corona and/or magnetic heating contributing to the disk response.
An Improved Technique for Measuring Plasma Density to High Frequencies on the Parker Solar Probe
Authors: Mozer F. S. , Bale S. D. , Kellogg P. J. , Larson D. , Livi R. , Romeo O. 
Published: February 2022

Abstract
The correlation between the plasma density measured in space and the surface potential of an electrically conducting satellite body with biased electric field detectors has been recognized and used to provide density proxies. However, for Parker Solar Probe, this correlation has not produced quantitative density estimates over extended periods of time because it depends on the energy-dependent exponential variation of the photoemission spectrum, the electron temperature, the ratio of the biased surface area to the conducting spacecraft surface area, the spacecraft secondary or thermal emission, the spacecraft distance from the Sun, etc. In this paper the density as a function of time and frequency to frequencies as high as the electron gyrofrequency is determined through least-squares fits of a function of the spacecraft potential to the plasma density measured on the Parker Solar Probe. This function allows correction for the many effects on the spacecraft potential other than that due to the plasma density. Some examples of plasma density obtained from this procedure are presented.
LISC Catalog of Star Clusters. I. Galactic Disk Clusters in Gaia EDR3
Authors: Li Zhongmu , Deng Yangyang , Chi Huanbin , Chen Jing , Liu Xuejie , Yan Chen , Chen Wen , Guo Wenkai , Xia Tao 
Published: February 2022

Abstract
This work searches for the candidates of Galactic disk star clusters in Gaia Early Data Release 3 (Gaia EDR3) and determines their basic parameters from color–magnitude diagrams (CMDs). A friends-of-friends method for membership determination and stellar population models including binary stars (ASPS) and rotating stars are adopted. As a result, 868 new star cluster candidates are found, besides 2729 known ones. When checking the CMD of each candidate, 61 new candidates show main sequences including a turnoff, which suggests that they are real star clusters. The basic parameters, including distance modulus, color excess, metallicity, age (or age range), primordial binary fraction, and rotating star fraction, are determined carefully by fitting the morphologies of CMDs of 61 newly identified star clusters and 594 known star clusters, which have relatively clear main sequences. The CMDs are fitted in considerable detail to ensure the reliability of property parameters of clusters. All final results are included in a new star cluster catalog, which is named LI team’s Star Cluster (LISC), and the catalog is available in the Zenodo repository.
In-orbit Timing Calibration of the Insight-Hard X-Ray Modulation Telescope
Authors: Tuo Youli , Li Xiaobo , Ge Mingyu , Nie Jianyin , Song Liming , Xu Yupeng , Zheng Shijie , Lu Fangjun , Zhang Shuang-Nan , Liu Congzhan , Cao Xuelei , Chen Yong , Qu Jinlu , Zhang Shu , Zhao Haisheng , Xiao Shuo , Wu Baiyang , Wen Xiangyang , Jiang Weichun , Meng Bin , Cui Weiwei , Li Wei , Zhang Yifei , Li Xufang , Yang Yanji , Tan Ying , Li Bing 
Published: February 2022

Abstract
We describe the timing system and the timing calibration results of the three payloads on board the Insight-Hard X-ray Modulation Telescope (Insight-HXMT). These three payloads are the High Energy X-ray telescope (HE; 20–250 keV), the Medium Energy X-ray telescope (ME; 5–30 keV), and the Low Energy X-ray telescope (LE; 1–10 keV). We present a method to correct the temperature-dependent period response and the long-term variation of the onboard crystal oscillator, especially for ME, which does not carry a temperature-compensated crystal oscillator. The times of arrival (ToAs) of the Crab pulsar are measured to evaluate the accuracy of the timing system. As the ephemeris of the Crab pulsar given by the Jodrell Bank Observatory has systematic errors around (Rots et al. 2004) 40 μs, we use the quasi-simultaneous observations of the X-ray Timing Instrument (XTI) on board the Neutron star Interior Composition Explorer (NICER) to produce the Crab ephemerides and to verify the timing system of Insight-HXMT. The energy-dependent ToAs’ offsets relative to the NICER measurements including the physical and instrumental origins are about 24.7 μs, 10.1 μs, and 864.7 μs, and the systematic errors of the timing system are determined to be 12.1 μs, 8.6 μs, and 15.8 μs, for HE, ME, and LE, respectively.
Solar Toroidal Field Evolution Spanning Four Sunspot Cycles Seen by the Wilcox Solar Observatory, the Solar and Heliospheric Observatory/Michelson Doppler Imager, and the Solar Dynamics Observatory/Helioseismic and Magnetic Imager
Authors: Liu Allison L. , Scherrer Philip H. 
Published: February 2022

Abstract
Forty-four years of Wilcox Solar Observatory, 14 years of Michelson Doppler Imager on the Solar and Heliospheric Observatory, and 11 years of Helioseismic and Magnetic Imager on the Solar Dynamics Observatory magnetic field data have been studied to determine the east–west inclination—the toroidal component—of the magnetic field. Maps of the zonal averaged inclination show that each toroidal field cycle begins at around the same time at high latitudes in the northern and southern hemispheres, and ends at the equator. Observation of these maps also shows that each instance of a dominant toroidal field direction starts at high latitudes near sunspot maximum and is still visible near the equator well past the minimum of its cycle, indicating that the toroidal field cycle spans approximately two sunspot cycles. The length of the extended activity cycle is measured to be approximately 16.8 yr.
Concomitant Use of Single Suture Anchor and Transosseus Repair Provide Optimal Results in Simultaneous Bilateral Quadriceps Tendon Rupture: A Case Report
Authors: Albar Husnul Fuad , Yudhadibrata Permana , Widjaja Arya Cipta 
Published: February 2022

Introduction
Bilateral quadriceps tendon rupture is a rare condition and often associated with underlying medical comorbidities such as chronic renal insufficiency. This case report is aimed to evaluate the surgical outcome using the combination of suture anchor and transosseus repair technique.

Presentation of Case
Presenting a 54-year-old male who sustained simultaneous bilateral quadriceps tendon rupture with history of right nephrectomy and chronic kidney disease requiring intermittent hemodialysis. He came with sudden bilateral knee pain, history of falling, and inability to walk since three weeks before admission to the hospital. Tenderness above the superior pole on both patella, accompanied with slight swelling and no active range of motion (ROM) of either knee joint was found on physical examination. Complete rupture of the quadriceps tendon of both knees at their osseus-tendon junction were revealed on magnetic resonance imaging (MRI).

Discussion
Recent literatures suggested that transosseus technique offers the safest and more stable tendon reattachment, while suture anchor provides biomechanical superiority. We tried to combine these advantages by incorporating both methods. Progressive active knee motion exercise was performed shortly after using the Kocher slab for 2 weeks.Subsequently, the patient can achieve painless, active extension and active 90°-120° knee flexion 1 month post-operatively.

Conclusion
The application of a single suture anchor with transosseus repair in quadriceps tendon rupture led to an optimal outcome, improved stability, and earlier rehabilitation.
Je est un autre… corps
Authors: Brunelle Julie , Condat Agnès 
Published: February 2022

Depuis cinq ans, une consultation spécialisée « identité sexuée » s’est ouverte dans le service de psychiatrie de l’enfant et de l’adolescent du Professeur Cohen à la Pitié Salpêtrière. Soixante et onze patients ont été reçus entre septembre 2013 et décembre 2017 et les demandes ne cessent de croître. Elles concernent des enfants prépubères et des adolescents. Dans la rencontre avec les adolescents qui se définissent comme « transgenres », la question du corps sexué est souvent centrale. La puberté venant rappeler pour eux le caractère définitif de l’appartenance au sexe d’assignation de naissance, le réel de l’anatomie déclenche, précipite ou majore la souffrance. Quelle est la nature de cette souffrance ? En particulier, peut-on parler d’une dimension persécutrice de ce corps sexué ? Dans un premier temps, nous préciserons quelques définitions du lexique utilisé dans le champ de la transidentité dont l’évolution est constante. Nous décrirons ensuite la cohorte des adolescents qui ont été reçus à la consultation pour enfin se pencher sur la question du corps sexué chez ces jeunes. Il s’agira d’une approche essentiellement clinique sans prétendre à une théorisation quelconque.
Du corps éprouvé au corps persécuteur : l’expérience limite des adolescents atteints de cancer face à la « violence ordinaire » des traitements oncologiques
Authors: Marioni Gabrielle 
Published: February 2022

Cet article interroge la fonction du psychologue au sein de l’équipe pluridisciplinaire dans un service d’oncologie pédiatrique. Cet article présente des situations d’adolescents atteints de cancer, qui sont adressés par les équipes soignantes comme étant potentiellement « déprimés par la maladie » et « à risque de ne plus vouloir poursuivre les protocoles thérapeutiques ». Le corps, en même temps qu’il est soigné, est « attaqué » par la lourdeur des traitements oncologiques et leurs conséquences. Cette violence inhérente aux traitements et les répercussions physiques et psychiques qu’elle induit, est rarement prise en compte pour expliquer la détresse de certains adolescents atteints de cancer, voire peut-être occultée par les équipes soignantes, qui convoquent souvent la violence de la maladie.
Où les mots manquent, dire l'indicible
Authors: Brun Anne-Marie Louise 
Published: February 2022

Le polyhandicap confronte les professionnels à des émotions souvent extrêmes, ayant trait à la très grande vulnérabilité, la dépendance, ainsi qu’à l’angoisse de mort. Dans tous les cas, la souffrance est difficilement dicible. L’empêchement verbal des personnes polyhandicapées induisent gestes, « comportements », et/ou cris mettant d'emblée les professionnels à rude épreuve, en les obligeant à chercher à comprendre, sans certitude, ce qui est ressenti et/ou exprimé, manifesté. Mettre des mots, dire la souffrance perçue et ressentie, permet de se recentrer sur ce qui donne du sens au travail, à savoir les relations de confiance, d'échange, forcément toujours précarisées dans un milieu où les modalités de relation sont toujours à même d’être fragilisées.
Réflexions autour de l’incarcération des mineurs : le point de vue d’un juge des enfants
Authors: Bouttier-Véron Sophie 
Published: February 2022

Quelle est la configuration pour un mineur, qui mène à sa mise en détention ? Selon quels critères ? Comment est-elle motivée et qu’en est-il attendu ? Quel sens cette privation de liberté a-t-elle pour l’adolescent concerné ? Quels sont les risques corrélés ? Peut-on éduquer en prison ? Enfin, de quoi la prison est-elle le nom ? Autant de questions auxquelles l’auteure tentera d’apporter des réponses, non exhaustives.
EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT
Authors: Guarnera Luca , Meconi Federico , Secchi Roberto , Pascale Maria Rosaria , Esposito Fabiana , Zizzari Annagiulia , Rapisarda Vito Mario , Rizzo Manuela , Pupo Livio , Cantonetti Maria 
Published: February 2022

Introduction Gastric Diffuse large B‐cell lymphoma (DLBCL) is the most common extra-nodal site of lymphoma’s involvement (30%-40% of all extranodal lymphomas and 55%-65% of all gastrointestinal lymphomas). However, gastric localizations are also sometimes found in systemic DLBCL. Gastric complications such as bleeding, perforation and stenosis under chemotherapy are well documented. Methods We retrospectively analyzed 15 patients with newly diagnosed DLBCL with gastrointestinal involvement. Endoscopies were performed in these patients before and after treatment. Treatment consisted in cyclophosphamide low-dose pre-phase chemotherapy before conventional-dose chemotherapy. Results Endoscopy at staging detected ulcers in 12 patients (80%). After low-dose pre-phase chemotherapy GI ulcers healed in 91.6% of cases (1 ulcer detected). After the whole treatment (Low-dose pre-phase + chemotherapy) 9 patients (60%) achieved complete response, 4 patients (26.6%) partial response, 2 (13,3%) patients presented disease progression. The most frequent adverse event was neutropenia (73.3%); the most frequent non hematological adverse event was transaminases elevation (20%). Conclusion Cyclophosphamide low-dose pre-phase chemotherapy resulted a safe and effective way to prevent adverse events in systemic DLBCL with gastrointestinal involvement.
Improving BNT162b2 mRNA vaccine tolerability without efficacy loss by Pidotimod supplementation
Authors: Ucciferri Claudio , Auricchio Antonio , Vecchiet Jacopo , Falasca Katia 
Published: February 2022

Background and objectives: A new pandemic has emerged across the world:Covid-19. Covid-19 has affected hundreds of millions of people globally. To stop the spread of the virus and gain a mass immunity several vaccines have been developed. BNT162b2-mRNA-vaccine has been shown to be largely effective and is widely administered. However the vaccine is not free from adverse events that could discourage vaccination in many people. The aim was evaluated adverse effect and immunological effect after second dose of BNT162b2-mRNA-vaccine in a healthcare population that take Pidotimod versus control subjects.
Methods: All nurses and doctors working in Covid-19 unit were proposed to participate, up to the enrollment of 30participants. 10 participants took Pidotimod 800mg bid orally fasting, from the fourth day before the second dose of the BNT162b2-mRNA-vaccine, for a total of six days. The remaining 20 participants did not take any therapy. We studied the differences in anti-SARS-CoV2 IgM and IgG levels and the difference of frequency of adverse events between the two groups
Results: Although there was no significant difference in IgG production between the two groups, we found a lower frequency of vaccine adverse events in the group supplemented with pidotimod.
Conclusions: This work demonstrates how pidotimod, despite not having a proven efficacy in increasing the production of antibodies, significantly reduces the adverse events described compared to people vaccinated without pidotimod supplementation. The results we described in this paper could encourage many more clinicians and people to vaccinate and gain the mass immunity needed to end this pandemic.