bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing Smartphone Virtual Reality Exposure Preparation to Care as Usual in Children Aged 6 to 14 Years Undergoing Magnetic Resonance Imaging: Protocol for a Multicenter, Observer-Blinded, Randomized Controlled Trial
Authors: van Spaendonck Zita , Leeuwenburgh Koen Pieter , Dremmen Marjolein , van Schuppen Joost , Starreveld Daniëlle , Dierckx Bram , Legerstee Jeroen S 
Published: December 2022

Background
A magnetic resonance imaging (MRI) procedure can cause preprocedural and periprocedural anxiety in children. Psychosocial interventions are used to prepare children for the procedure to alleviate anxiety, but these interventions are time-consuming and costly, limiting their clinical use. Virtual reality (VR) is a promising way to overcome these limitations in the preparation of children before an MRI scan.

Objective
The objective of this study is (1) to develop a VR smartphone intervention to prepare children at home for an MRI procedure; and (2) to examine the effect of the VR intervention in a randomized controlled trial, in which the VR intervention will be compared to care as usual (CAU). CAU involves an information letter about an MRI examination. The primary outcome is the child’s procedural anxiety during the MRI procedure. Secondary outcomes include preprocedural anxiety and parental anxiety. We hypothesize that the VR preparation will result in a higher reduction of the periprocedural anxiety of both parents and children as compared to CAU.

Methods
The VR intervention provides a highly realistic and child-friendly representation of an MRI environment. In this randomized controlled trial, 128 children (aged 6 to 14 years) undergoing an MRI scan will be randomly allocated to the VR intervention or CAU. Children in the VR intervention will receive a log-in code for the VR app and are sent cardboard VR glasses.

Results
The VR smartphone preparation app was developed in 2020. The recruitment of participants is expected to be completed in December 2022. Data will be analyzed, and scientific papers will be submitted for publication in 2023.

Conclusions
The VR smartphone app is expected to significantly reduce pre- and periprocedural anxiety in pediatric patients undergoing an MRI scan. The VR app offers a realistic and child-friendly experience that can contribute to modern care. A smartphone version of the VR app has the advantage that children, and potentially their parents, can get habituated to the VR environment and noises in their own home environment and can do this VR MRI preparation as often and as long as needed.

Trial Registration
ISRCTN Registry ISRCTN20976625; https://www.isrctn.com/ISRCTN20976625

International Registered Report Identifier (IRRID)
DERR1-10.2196/41080
Pesquisas brasileiras de enfermagem com adolescentes pela teoria das representações sociais: revisão integrativa
Authors: Santos Gabriela Silva dos , Azevedo Queiroz Ana Beatriz , Barbosa Moratório de Paula Michelle , Bulcão Pinto Carina , Gomes Dargan Vieira Bianca 
Published: December 2022

Objetivo: apresentar o perfil das produções científicas desenvolvidas no âmbito da enfermagem brasileira à luz da Teoria das Representações Sociais, que contemplam a saúde do adolescente. Método: revisão integrativa cujos artigos estão indexados nas bases de dados, CINAHL, MEDLINE Complete, BDENF e LILACS. Resultados: foram encontradas 11 publicações disponíveis na íntegra. As publicações estão em periódicos classificados pelo sistema Qualis da seguinte maneira, 04 estudos A2, 06 estudos B1 e 01 estudo em periódico B2. Os contextos sociais em que os adolescentes estavam inseridos no momento da pesquisa são: escolas e serviços de saúde. Na vertente metodológica para coleta de dados nos estudos, houve predominância da entrevista semiestruturada. Todas as pesquisas foram realizadas em território brasileiro. Conclusão: Dos onze artigos analisados seis discorrem sobre a questão da saúde sexual e reprodutiva dos adolescentes o que reforça a importância do papel da enfermagem nas ações de prevenção e promoção da saúde voltadas para esse público. As pesquisas realizadas com adolescentes tendo por fundamento as Representações Sociais permitem a construção de um conhecimento inovador, elaborado sob ângulos que rompem com a metodologia tradicional servindo de alicerce para assistência de enfermagem voltada para esse público.
ADMET-Evaluation, Pharmacokinetics, Drug-likeness and Medicinal Chemistry of GCMS Identified Bioactive Compounds of Moringa oleifera Natural-Ripened-Dried Methanolic Pod Extract (MOMPE) as a Potential Source of Natural Drug Frontrunner for Next Generation
Authors: Kandeepan C. , Suganandam K. , Jeevalatha A. , Kavitha N. , Senthilkumar N. , Sutha S. , Seyed Mohamed Ali , Gandhi Sanyam , Ramya S. , Grace Lydial Pushpalatha G , Abraham GC. , King Immanuel J. , Jayakumararaj R. 
Published: December 2022

Over centuries, Moringa oleifera has been used as an integral part of Ayurveda, Siddha and Unani systems of medicine, besides this miracle tree has a wide range of nutritional and bioactive compounds, including proteins, essential amino acids, carbohydrates, lipids, fiber, vitamins, minerals, phenolic compounds, phytosterols and others. The miracle tree is endowed with a wide range of pharmacological properties, including anti-diabetic, anti-inflammatory, anti-carcinogenic, antioxidant, cardioprotective, antimicrobial and hepatoprotective activities. However, deeper dimensions of authentic data on plant based natural products in relation to drug discovery, pharmacokinetics properties of biomolecules is far lacking. ADMET prospecting is eventually expected to contribute to success of MO based lead candidates in drug design, development program besides saving time and money. This study is the first of its kind reporting summative ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicology) properties of all bioactive compounds Moringa oleifera methanolic pod extract (MOMPE) as a potential source of natural drug lead using Swiss ADME. A total of 12 compounds namely - 7-Octadecyne, 2-methyl- (C19H36); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 6,9,12,15-Docosatetraenoic acid, me (C23H38O2); Cyclohexanol, 5-methyl-2-(1-methylethyl)- (C10H20O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); Palmitic acid vinyl ester (C18H34O2); .γ.-Tocopherol (C28H48O2); Vitamin E (C29H50O2); Cholesta-7,9(11)-dien-3-ol, 4,4-dim (C29H48O); γ.-Sitosterol (C29H50O); Stigmasta-5,24(28)-dien-3-ol, (3.β.,24Z)- (C29H48O). Most of the MOPBNPs are non-substrate for both P-gp (P-glycoprotein) and CYP (Cytochrome P-450 isoenzymes). All the compounds were evaluated for properties viz., GI absorption, BBB permeant, Pgp substrate, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 inhibitors, Lipinski, Ghose, Veber, Egan, Muegge, rule and Bioavailability Score to provide baseline information on PBNPs in MONRD pod.
Keywords: PBNPs; NGDDT; ADMET; Moringa oleifera; Secondary Metabolites MONRD pod
In Vivo study of Antidiabetic Activity from Ethanol Extract of Clitoria ternatea L. Flower
Authors: Ginting Evi Ekayanti , Rumanti Ruth Mayana , Savira Dara , Ginting Pricella , Marbun Novarianti , Leny Leny 
Published: December 2022

Background: Clitoria ternatea L. or telang flower is a plant whose all parts have benefits for the human body. The benefits of telang flower include antioxidant, antidiabetic, antiobesity, anticancer, anti-inflammatory, antibiotic and hepatoprotective agent. Clitoria ternatea L. flower as an antidiabetic treatment works by increasing insulin secretion, inhibiting the formation of advanced glucose end products, as well as inhibiting the work of enzymes involved in the production of glucose in the blood. In this study using an experimental method, using 25 mice which were divided into 5 groups. The negative control group (aquadest), the positive control group (glibenclamide 5 mg), and the three groups with variations in the dose of 96% ethanol extract of telang flower 200, 400, 600 mg/kg BW. The results: The results showed that the negative control group did not experience a decrease in blood sugar levels; the positive control group by giving glibenclamide 5 mg experienced a decrease in blood sugar levels of up to 48.6 mg/dl. In 200 mg dose extract; 400; 600 mg of tested animals showed a decrease in blood sugar up to 48.2 mg/dl, 31.2 mg/dl, 43 mg/dl respectively. The conclusion: Based on the data obtained, it was then analyzed statistically using the One Way ANOVA test, resulting in a significant value <0.05, then the Kruskal-Wallis Test was carried out. It could be concluded that there was a significant difference in decreasing blood sugar levels. Different dose of Clitoria ternatea L. extract gives a significant effect on reducing blood sugar levels.
Keywords: Antidiabetic, Extract, Clitoria ternatea L., Flower
Differences in Saliva pH before and after Drinking Packed Cow’s Milk in Children Aged 6 -12 Years
Authors: Sulastri Siti , Sulistyani Herastuti 
Published: December 2022

Background: The main factors that cause dental caries are the host (teeth and saliva), substrate (food), microorganisms, and time. Saliva as a host factor plays a role in protective mechanisms. Several factors cause changes in salivary pH to include the average salivary flow rate, oral microorganisms, salivary buffer capacity, and frequently consumed foods and beverages; One of them is milk. Objective: To investigate the differences in salivary pH before and after drinking packed cow’s milk in children aged 6-12 years old. Methods: Quasi-experimental research methods were conducted using Pretest and Posttest Control Group Designs. The instruments in this study used a pH meter. Statistical Test using Student t-Test. Results: There is no difference in the average pH of saliva 0 minutes after drinking cow's milk packaged brand A and brand B (p= 0.772 and p=0.384, respectively). There is an average difference in salivary pH 5 minutes after drinking cow's milk packaged brand A and brand B (p=0.001). The results of the analysis between 5 minutes after drinking liquid milk packaged brand A with brand B there was a significant difference in reducing the pH of saliva (p = 0.001). Conclusion: There is a difference in salivary pH before and after drinking packed cow's milk in children aged 6-12 years.
Keywords: Salivary pH, Packed cow’s milk, Elementary School
Viduslaiku importa keramika Ikšķilē
Authors: Dumpe Baiba , Gunnarssone Alise , Muižnieks Vitolds 
Published: December 2022

Šī raksta mērķis ir izpētīt, ko par viduslaiku Ikšķiles vēsturi varam uzzināt, analizējot keramikas atradumus, un kā tie saistās ar rakstītos avotos atrodamajām ziņām un arheoloģiskajiem pētījumiem par vietas apbūvi un izmantošanu. Īpaša uzmanība pievērsta apstākļiem, kas varēja sekmēt noteiktu viduslaiku keramikas veidu nonākšanu Ikšķilē, kā arī tam, kā trauku palieku stāvokli kultūrslānī ietekmējusi vietas izmantošana jaunajos laikos. Rakstā tuvāk analizēti vairāki viduslaiku ievestās keramikas veidi. Noteiktas pazīmes, kas var palīdzēt turpmākos pētījumos pazīt un klasificēt viduslaiku keramikas paraugus. Pētījumā izmantota keramika, kas iegūta Jāņa Graudoņa vadītajos arheoloģiskajos izrakumos laikā no 1968. līdz 1975. gadam. Keramikas kolekcija glabājas Latvijas Nacionālā vēstures muzeja krājumā.
Trepanācijas tikai privileģētajiem? Latvijas dzelzs laikmeta gadījumu izpēte (7.–10. gs.)
Authors: Gerhards Guntis , Vilcāne Antonija , Pētersone-Gordina Elīna , Ērkšķe Aija 
Published: December 2022

Pētījuma mērķis skaidrot iespējamo trepanāciju saistību Latvijas 7.–10. gs. arheoloģiskajā materiālā ar indivīda sociālo statusu. Rakstā analizētas trepanācijas no Lejasbitēnu, Čunkānu-Dreņģeru un Īdeņu kapulaukiem. Izpēte veikta makroskopiski. Trepanācijas konstatētas septiņiem pieaugušiem vīriešiem un vienā gadījumā nepieaugušam sieviešu dzimtes indivīdam. Vairākumā gadījumu tās veiktas ar kasīšanas metodi. Iespējamais trepanāciju cēlonis galvaskausa traumas. Daļa indivīdu šo operāciju pārdzīvojuši. Indivīdu iespējamais sociālais statuss noteikts, balstoties uz senlietu materiālu gan konkrētā kapulaukā, gan plašākā teritoriālā kontekstā. Vismaz daļa vīriešu, kuriem veikta trepanācija, saistāma ar augstu sociālo statusu tā laika sabiedrībā. Limitējošais izpētes faktors postītie apbedījumi ar nepilnīgu kapa inventāru.
Clinical Evaluation of Low-shrinkage Bioactive Material Giomer Versus Nanohybrid Resin Composite Restorations: A Two-year Prospective Controlled Clinical Trial
Authors: Toz-Akalin T , Öztürk-Bozkurt F , Kusdemir M , Özsoy A , Yüzbaşıoğlu E , Özcan M 
Published: December 2022

SUMMARY
This study evaluated the clinical performance of low-shrinkage bioactive resin composite compared with a conventional nanohybrid resin composite. A total of 35 patients (18 males, 17 females; mean age: 29±9 years old) received, randomly, 35 pairs of fillings restored with either low-shrinkage bioactive material employing Giomer filler technology (Beautifil II LS, Shofu Inc, Kyoto, Japan) or conventional nanohybrid resin composite (Clearfil Majesty Posterior, Kuraray, Japan) in Class I and Class II cavities. Two operators made all the restorations using the corresponding adhesive resins: FL-Bond II (Shofu Inc) and Clearfil SE Bond (Kuraray), according to each manufacturer’s instructions. Two calibrated operators evaluated the restorations two weeks after placement (baseline), at six months, and at one and two years using FDI criteria (Scores 1–5). Data were analyzed using the McNemar test (α=0.05). Mean observation time was 27.4 ± 4.1 months (min=20.8; max=33.7). In both groups, according to FDI criteria, the restorations were mostly rated with best scores (Score 1 or 2) for biological, functional, and optical parameters. For one filling in the group restored with nanohybrid resin composite, a small and localized secondary caries lesion was observed and monitored at the one- and two-year follow-ups. One restoration in the low-shrinkage Giomer restorative group was accepted as a failure due to retention loss. Over the two-year follow-up, both the Giomer and the nanohybrid resin composite restorations’ performance was clinically acceptable.
Assistance and Strengthening of Kenongo Village MSMEs through Branding and Product Legality during the Covid-19 Pandemic
Authors: Dewi Santi Rahma , Sriyono Sriyono , Sumartik Sumartik 
Published: December 2022

AbstrakDesa Kenongo Kecamatan Tulangan Kabupaten Sidoarjo, merupakan salah satu desa di wilayah Sidoarjo yang memiliki banyak anggota UMKM. Dari hasil pemetaan awal jumlah UMKM di Desa Kenongo adalah 210 dengan berbagai macam jenis usaha. Jenis usaha yang ada adalah konveksi, batik, souvenir, makanan dan minuman, serta berbagai macam kerajinan tangan lainnya. Dengan jumlah UMKM yang cukup banyak ini, masih sangat sedikit yang mempunyai legalitas usaha serta kemampuan untuk membranding usahanya.Tujuan pendampingan ini adalah mewujudkan UMKM yang memiliki kualitas bagus dan dapat bersaing serta bertahan di masa pandemi dengan cara 1) Branding produk melalui media sosial serta memberikan keahlian agar dapat membuat sendiri media pemasaran. Selanjutnya yang 2) Legalitas usaha bagi UMKM agar lebih berkualitas dan terpercaya.Hasil pendampingan ini adalah meningkatnya nilai penjualan meskipun belum sama seperti sebelum pandemi, dan meningkatnya kesadaran pemilik UMKM untuk legalitas usahanya. Pendampingan ini juga membentuk kelompok UMKM dengan struktur baru yang lebih terorganisir untuk membantu pelaku UMKM dalam pengembangan usahanya. Pendampingan akan berkelanjutan di tahun kedua dan ketiga yaitu inovasi produk serta pengelolaan keuangan. Kata kunci : branding produk, legalitas Abstract Kenongo Village, Tulangan District, Sidoarjo Regency, is one of the villages in the Sidoarjo region which has many UMKM members. From the results of the initial mapping, the number of MSMEs in Kenongo Village was 210 with various types of businesses. The types of businesses that exist are convection, batik, souvenirs, food and beverages, and various other handicrafts. With this large number of MSMEs, very few have business legality and the ability to compare their businesses.The aim of this assistance is to create MSMEs that have good quality and can compete and survive during a pandemic by 1) Branding products through social media and providing expertise so that they can create their own marketing media. Furthermore, 2) Business legality for MSMEs to be more qualified and reliable.The result of this assistance is an increase in sales value even though it is not the same as before the pandemic, and an increase in the awareness of MSME owners for the legality of their business. This mentoring also forms MSME groups with a new, more organized structure to assist MSME players in developing their businesses. Assistance will be sustainable in the second and third years, namely product innovation and financial management. Keywords: product branding, legality
Pemberdayaan Tanaman Obat Keluarga Dan Senam Anti Rematik Sebagai Pencegahan Penyakit Arthritis
Authors: Hidayat Cahya Tribagus , Jalil Abdul 
Published: December 2022

Penyakit arthritis atau reumatik adalah penyakit yang menyerang sistem muskuloskeletal dan persendian, yang melibatkan beberapa organ dan sistem tubuh secara keseluruhan, yang ditandai dengan pembengkakan, dan nyeri sendi. Dimana penyakit arthritis sering terjadi pada masyarakat usia dewasa. Prevalensi Arthritis di dunia relatif konstan yaitu berkisar antara 0,5-1%. Jumlah dewasa yang memiliki riwayat penyakit arthritis di Desa Karangpring, Kecamatan Sukorambi Jember sebanyak 234 orang (54,29%). Terapi non farmakologi yang berupa demonstrasi tanaman obat keluarga atau toga yang digunakan untuk membuat infuswater dan senam anti rematik sebagai alternative yang mudah untuk pencegahan penyakit arthritis tersebut. Kegiatan pengabdian ini menggunakan tiga metode yaitu cerama, demonstrasi dan tutorial. Kegiatan berlangsung dengan lancar, hal tersebut terlihat dari antusiasme peserta.
Branding, Packaging, Marketing Susu Kurma Di Kelompok Nasyiatul Aisyiyah Kebonsari Sumbersari Kabupaten Jember
Authors: Juariyah Juariyah , Faozen Faozen 
Published: December 2022

Kegiatan PKM Nasyiatul Aisyiyah Sumbersari yang memiliki usaha binaan Eena Susu Kurma telah dilakukan dengan tujuan mengembangkan usaha minuman susu kurma madu. Adapun permasalahan yang ditemui antara lain (1) Minimnya pengetahuan anggota terkait terkait Digital Marketing (2) Menurunnya Konsumen pembeli minuman susu kurma madu di Masa Pendemi (3) Belum memiliki branding pengemasan minuman yang menarik (4) Minimnya akses informasi dan media teknologi. Solusi yang ditawarkan adalah dengan mengadakan pelatihan dan simulasi Branding packaging produk susu kurma madu (5) Menyusun Modul Pelatihan; (6) Pendampingan mitra dalam mengoptimalkan potensi. (7) Mendaftarkan Membuatkan Blog dan Website, serta instagram. Target luaran yang akan dicapai adalah meningkatnya pemahaman peserta pelatihan, meningkatnya penjualan susu kurma madu, menyusun artikel terkait pengabdian berupa jurnal nasional, prosiding nasional, foto dan video dokumentasi kegiatan, blog dan Website. Adapun kegiatan meliputi pelatihan, sharing solusi diskusi, melaksanakan koordinasi dengan mitra, mengidentifikasi potensi mitra, penyusunan laporan kegiatan pembuatan laporan, publikasi kegiatan, pembuatan artikel, dan publikasi jurnal nasional terakreditasi
Pelatihan Pengembangan Media Pembelajaran Berbasis Internet of Thing untuk Meningkatkan Kompetensi Guru SMK
Authors: Asnil Asnil , Eliza Fivia - 
Published: December 2022

Kegiatan pengabdian kepada masyarakat ini di dasari oleh permasalahan yang sering muncul di Sekolah Menengah Kejuruan (SMK). Diantaranya kemampuan guru dalam menghadapi kemajuan teknologi yang berpengaruh terhadap proses pembelajaran, seperti inovasi guru dalam pengembangan media pembelajaran. Upaya untuk mengatasi permasalahan tersebut adalah dengan memberikan pelatihan kepada guru berdasarkan permasalahan yang ada dan hasil diskusi dengan mitra. Topik pembelajaranya adalah mengenai penggunaan mikrokontroller pada bidang Internet of Thing (IoT). Dari kegiatan ini juga dihasilkan sebuah media pebelajaran berupa trainer aplikasi mikrokontroller menggunakan konsep IoT yang dapat dimanfaatkan oleh guru dan siswa dalam proses pembelajaran.
Pelatihan Aplikasi Mikrokontroller Sebagai Upaya Peningkatan Kompetensi Guru SMK
Authors: Dewi Citra , Ahyanuardi Ahyanuardi , Asnil Asnil , Astrid Erita 
Published: December 2022

Kegiatan yang dilakukan didasari oleh permasalahan yang ada di SMK N 1 Sutera. Diantaranya kemampuan guru dalam mengikuti perkembangan teknologi. Hal ini secara tidak langsung berdampak terhadap kompetensi siswa. Berdasarkan hasil diskusi dengan pihak SMK N 1 Sutera terhadap permasalahan yang ada, maka solusi yang dilakukan adalah mengadakan pelatihan untuk guru-guru mengenai aplikasi mikrokontroller. Hal ini juga berkaitan dengan beberapa mata pelajaran yang ada berdasarkan kurikulum yang digunakan. Topik pembahasan pada pelatihan adalah aplikasi dari mikrokontroller menggunakan perangkat RFID dalam mengendalikan beban kelistrikan. Kegiatan pelatihan juga menghasilkan Trainer aplikasi dari mikrokontroller berupa trainer dasar RFID. Trainer ini dapat digunakan oleh guru dan siswa dalam proses pembelajaran di sekolah sebagai media pembelajaran.
PKM Bagi Anak Asuh Panti Asuhan Amanah Puteri Melalui Pengolahan Limbah Rumah Tangga dalam Mewujudkan Tujuan SDGs Di Era Reformasi Industri 4.0
Authors: Idris Idris , Mata Joan , Putri Dewi Zaini , Adry Melti Roza , Satria Doni , Yeni Isra 
Published: December 2022

Pemanfaatan sampah anorganik dan organik dapat mengurangi terjadinya kerusakan lingkungan. Melalui program PKM kepada anak-anak Panti Asuhan Amanah Putri, maka anak-anak dapat memanfaatkan sampah yang ada dilingkungan panti asuhan untuk dapat dikelola menjadi barang bernilai ekonomis. Salah satu program yang akan dijalankan melalui PKM ini adalah membuat kerajinan dari sampah anorganik dan membuat ecoenzym dari sampah organic. Kegiatan yang akan dilaksanakan mencakup 3 aspek. (1) Aspek manajemen meliputi kegiatan Capacity Building terhadap anak asuh panti asuhan Amanah Putri Kota Padang (2) aspek produksi yang mencakup kegiatan workshop pemanfaatan limbah organic dan anorganik menjadi benda yang bernilai ekonomis. Sedangkan dalam (3) aspek pemasaran, kegiatan ini didukung oleh keberadaan Asosiasi Bank Sampah. Hasil yang diperoleh bahwa dengan pemanfaatan sampah anorganik berupa tempat tumbler dan sampah anorganik berupa Ecoenzym mendorong terjadi peningkatan keterampilan pengolahan sampah menjadi nilai ekonomis dan dapat meningkatkan pengetahuan anak-anak tentang pentingnya peduli lingkungan.