bluuebunny/crossref_metadata_2025_split huggingface dataset:
Should I Trust You? Bidder’s Earnings Quality as an Indicator of Trustworthiness in Earnout Agreements
Authors: Prencipe Annalisa , Viarengo Luca 
Published: March 2022

Synopsis The research problem This paper aims to test whether an acquirer’s past earnings quality (proxied by the level of earnings management) serves as an indicator of its trustworthiness in view of the inclusion of an earnout agreement in an acquisition contract. Motivation Prior studies highlighted the benefits of earnout agreements, showing that they help reduce adverse selection problems and valuation risk faced by the acquirers. However, not much attention has been paid to the risks that these contracts entail. The majority of earnouts are based on accounting performance measures, which may be subject to earnings management by the acquirer to reduce, or even avoid, contingent payments. Therefore, the decision to include an earnout in an acquisition may depend on the sellers’ perceived probability that the acquirer will use opportunistic tactics to avoid the contingent payment, as indicated by the acquirer’s past behavior. The test hypotheses H1: The likelihood of inclusion of earnouts in acquisition deals is negatively associated with the level of earnings management in the acquirer’s past financial statements. H2: The relation between earnings management and the use of earnouts is stronger when the bidder has no acquisition track record. Target population M&A advisors, financial analysts, stakeholders of companies engaging in M&A deals. Adopted methodology Logit regressions, propensity score matching analyses for robustness. Analyses Using a sample of 8,968 acquisition deals completed by US listed companies between 2002 and 2014, we examine the association between the use of earnouts and bidder’s earnings quality (proxied by the level of earnings management) controlling for the determinants of the use of earnouts described by previous literature. We collected acquisitions data from Thomson ONE Banker and accounting information from Compustat. Using logit models, we regress the choice to include an earnout in an M&A deal on several earnings management proxies and on the interaction between the latter variables and bidder’s acquisition track record. Findings We find robust evidence that the level of the acquirer’s past earnings management is negatively associated to the probability of inclusion of an earnout in acquisition contracts. This association is stronger if the bidder has no prior acquisition history and is robust to various measures of earnings management and to controls for other external monitoring mechanisms.
Opinion Mining for Software Development: A Systematic Literature Review
Authors: Lin Bin , Cassee Nathan , Serebrenik Alexander , Bavota Gabriele , Novielli Nicole , Lanza Michele 
Published: March 2022

Opinion mining, sometimes referred to as sentiment analysis, has gained increasing attention in software engineering (SE) studies. SE researchers have applied opinion mining techniques in various contexts, such as identifying developers’ emotions expressed in code comments and extracting users’ critics toward mobile apps. Given the large amount of relevant studies available, it can take considerable time for researchers and developers to figure out which approaches they can adopt in their own studies and what perils these approaches entail.
We conducted a systematic literature review involving 185 papers. More specifically, we present (1) well-defined categories of opinion mining-related software development activities, (2) available opinion mining approaches, whether they are evaluated when adopted in other studies, and how their performance is compared, (3) available datasets for performance evaluation and tool customization, and (4) concerns or limitations SE researchers might need to take into account when applying/customizing these opinion mining techniques. The results of our study serve as references to choose suitable opinion mining tools for software development activities and provide critical insights for the further development of opinion mining techniques in the SE domain.
All in One: Design, Verification, and Implementation of SNOW-optimal Read Atomic Transactions
Authors: Liu Si 
Published: March 2022

Distributed read atomic transactions are important building blocks of modern cloud databases that magnificently bridge the gap between data availability and strong data consistency. The performance of their transactional reads is particularly critical to the overall system performance, as many real-world database workloads are dominated by reads. Following the SNOW design principle for optimal reads, we develop LORA, a novel SNOW-optimal algorithm for distributed read atomic transactions. LORA completes its reads in exactly one round trip, even in the presence of conflicting writes, without imposing additional overhead to the communication, and it outperforms the state-of-the-art read atomic algorithms.To guide LORA’s development, we present a rewriting-logic-based framework and toolkit for design, verification, implementation, and evaluation of distributed databases. Within the framework, we formalize LORA and mathematically prove its data consistency guarantees. We also apply automatic model checking and statistical verification to validate our proofs and to estimate LORA’s performance. We additionally generate from the formal model a correct-by-construction distributed implementation for testing and performance evaluation under realistic deployments. Our design-level and implementation-based experimental results are consistent, which together demonstrate LORA’s promising data consistency and performance achievement.
Opinion Column: Evolution of topics in the multimedia community
Authors: Redi Miriam , Alameda-Pineda Xavier 
Published: March 2022

For this edition of the SIGMM Opinion Column, we asked members of the Multimedia community to share their impressions about the shift of scientific topics in the community over the years, namely the evolution of "traditional" and "emerging" Multimedia topics.
This subject has emerged in several conversations over the 2 years of history of the SIGMM Opinion Column, and we report here a summary of recent and old discussions, happened over different channels --- our Facebook group, the SIGMM Linkedin group, and in-person conversations between the column editors and MM researchers --- with hopes, fears and opinions around this problem. We want to thank all participants for their precious contribution to these discussions.
Outcome of Endoscopic Ultrasound-Guided Sampling of Mediastinal Lymphadenopathy
Authors: Park Tae Young , Moon Jeong Seop 
Published: March 2022

Background and Objectives. Endoscopic ultrasound (EUS)- guided transesophageal fine needle biopsy has been used as a method for histologic evaluation of mediastinal lymph nodes (LNs). This study aimed to compare the outcomes of the EUS-guided sampling with mediastinal lymphadenopathy using a 19-gauge trucut needle and 22-gauge fine needle aspiration (FNA) needle. Methods. From May 2006 to January 2017, patients with mediastinal lymphadenopathy, who received an EUS-guided trucut biopsy or an FNA biopsy, were retrospectively reviewed. Demographic data, endosonographic characteristics of LNs including size, shape, border, echotexture, and echogenicity, diagnostic yield, and adverse events between the trucut needle group and aspiration needle group were compared. Results. A total of 69 patients (trucut group,

n
=
33

vs. aspiration group,

n
=
36

) were identified. There were no significant differences in demographic data, indication for an EUS-guided biopsy, location of LNs, number of needle passes, and endosonographic features of LNs between the two groups. The sizes of LNs were larger in the trucut group than in the aspiration group (

28.9
±
14.0

mm vs.

21.1
±
8.8

mm,

P
=
0.007

). However, there was no significant difference in the ratio of LNs that were ≥10 mm in both groups. The overall accuracy of the EUS-guided biopsy for the diagnosis of malignant lesions was 79.7% (55/69). There were no significant differences in the histological diagnostic yield of malignant LNs between the two groups. There were no significant procedure-related adverse events in both groups. Conclusion. The EUS-guided biopsy can be a useful method for histologic evaluation of mediastinal nodal lesions.
Numerical Simulation of a 3D Seepage Field of an Asphaltic and Concrete Core Rockfill Dam in an Arid Area
Authors: Guo Da-Hai , Sun Yun , Gu Xin-Bao 
Published: March 2022

This investigation focused on the three-dimensional (3D) seepage field simulation of an asphaltic concrete core rockfill dam (ACRD) under the design water level conditions. At first, the finite element theory of seepage is introduced in the arid area; then, a hydro-junction projection on the Nuer River in Xinjiang is selected as engineering background, the finite element model of a seepage field of an asphaltic and concrete core rockfill dam under the design water level condition is established, and a boundary condition is determined, and the next distribution of a seepage field of different profiles are plotted, and the monitoring value of different points is compared with the finite element solution; conclusions can be drawn that when the antiseepage system of the dam foundation is good, the water level at the downstream side of the core wall is greatly reduced; for the dam foundation, the effects of reducing head of the cutoff wall are rather obvious, and for the dam body, certain leakage defects at the joint of an impermeable body in the cross sections

0
+
456.5

m

and

0
+
540

m

can exist. For the dam-around seepage, the hydrogeological condition conforms to the actual conditions. These conclusions can provide great significance for the future design.
Disrupting Circadian Rhythm via the PER1–HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer
Authors: Wang Jiao , Huang Qiong , Hu Xingbin , Zhang Shuyi , Jiang Yu , Yao Guangyu , Hu Kongzhen , Xu Xin , Liang Bishan , Wu Qijing , Ma Zhenfeng , Wang Yawen , Wang Chunlin , Wu Zhenzhen , Rong Xiaoxiang , Liao Wangjun , Shi Min 
Published: March 2022

Abstract

Trastuzumab is the only approved targeted drug for first-line treatment of HER2-positive advanced gastric cancer, but the high rate of primary resistance and rapid emergence of secondary resistance limit its clinical benefits. We found that trastuzumab-resistant (TR) gastric cancer cells exhibited high glycolytic activity, which was controlled by hexokinase 2 (HK2)-dependent glycolysis with a circadian pattern [higher at zeitgeber time (ZT) 6, lower at ZT18]. Mechanistically, HK2 circadian oscillation was regulated by a transcriptional complex composed of PPARγ and the core clock gene PER1. In vivo and in vitro experiments demonstrated that silencing PER1 disrupted the circadian rhythm of PER1–HK2 and reversed trastuzumab resistance. Moreover, metformin, which inhibits glycolysis and PER1, combined with trastuzumab at ZT6, significantly improved trastuzumab efficacy in gastric cancer. Collectively, these data introduce the circadian clock into trastuzumab therapy and propose a potentially effective chronotherapy strategy to reverse trastuzumab resistance in gastric cancer.

Significance:
In trastuzumab-resistant HER2-positive gastric cancer, glycolysis fluctuates with a circadian oscillation regulated by the BMAL1–CLOCK–PER1–HK2 axis, which can be disrupted with a metformin-based chronotherapy to overcome trastuzumab resistance.
Addressing Public Health Aspects of Cancer Center Catchment Areas
Authors: Lieberman-Cribbin Wil , Taioli Emanuela 
Published: March 2022

Abstract
Serving the catchment area has become an integral mission of cancer centers, and examining the geographic extent of cancer coverage is an important component aimed at efficiently maximizing care and reducing the cancer burden. In addition to cancer incidence and mortality, geographic analyses of cancer center coverage must also be measured by the need for reducing the prevalence of risk factors and increasing screening rates within communities. Here, we briefly comment on these additional parameters and their relevance to analyzing cancer coverage across the United States.
See related article by Leader et al., p. 955
Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti–PD-1 Therapy
Authors: Chida Keigo , Kawazoe Akihito , Suzuki Toshihiro , Kawazu Masahito , Ueno Toshihide , Takenouchi Kazumasa , Nakamura Yoshiaki , Kuboki Yasutoshi , Kotani Daisuke , Kojima Takashi , Bando Hideaki , Mishima Saori , Kuwata Takeshi , Sakamoto Naoya , Watanabe Jun , Mano Hiroyuki , Ikeda Masafumi , Shitara Kohei , Endo Itaru , Nakatsura Tetsuya , Yoshino Takayuki 
Published: March 2022

Abstract

Purpose:
Transcriptomic profiling was performed for microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal tumors to determine the predictors of response to PD-1 blockade.

Experimental Design:
Thirty-six patients with MSI-H/dMMR gastrointestinal tumors, including gastric cancer, colorectal cancer, cholangiocarcinoma, small intestine cancer, and pancreatic cancer, being treated with PD-1 blockade were analyzed. We conducted the transcriptomic analysis of gastrointestinal tumors using RNA sequencing data, including the consensus molecular subtypes (CMS) of colorectal cancer.

Results:
Gene set enrichment analysis (GSEA) demonstrated that non-responders had upregulations of epithelial–mesenchymal transition, angiogenesis, hypoxia, mTORC1, TNF-α, KRAS, Wnt/β-catenin, TGF-β, and various metabolism-related signaling pathways. Meanwhile, the IFNγ pathway was enriched in responders. On the basis of the leading-edge analysis of GSEA, VEGF-A was significantly correlated with enriched pathways in non-responders. Patients with high VEGF-A expression, compared with those with low expression, had significantly shorter progression-free survival [PFS; median 4.8 months vs. not reached (NR), P = 0.032] and overall survival (median 11.1 months vs. NR, P = 0.045). Among 13 patients with colorectal cancer evaluable for CMS classification, the objective response rate was 100%, 0%, 0%, and 16.7% in CMS1, CMS2, CMS3, and CMS4, respectively. Patients with CMS1 had significantly longer PFS (NR vs. 4.8 months, P = 0.017) than those with CMS2, CMS3, or CMS4.

Conclusions:
Several transcriptomic features, including CMS classification and related genes, were associated with response to PD-1 blockade in MSI-H/dMMR gastrointestinal tumors. These findings can help develop predictive biomarkers or combination immunotherapies.
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor
Authors: Koblish Holly K. , Wu Liangxing , Wang Liang-Chuan S. , Liu Phillip C.C. , Wynn Richard , Rios-Doria Jonathan , Spitz Susan , Liu Hao , Volgina Alla , Zolotarjova Nina , Kapilashrami Kanishk , Behshad Elham , Covington Maryanne , Yang Yan-ou , Li Jingwei , Diamond Sharon , Soloviev Maxim , O'Hayer Kevin , Rubin Stephen , Kanellopoulou Chrysi , Yang Gengjie , Rupar Mark , DiMatteo Darlise , Lin Luping , Stevens Christina , Zhang Yue , Thekkat Pramod , Geschwindt Ryan , Marando Cindy , Yeleswaram Swamy , Jackson Jeff , Scherle Peggy , Huber Reid , Yao Wenqing , Hollis Gregory 
Published: March 2022

Abstract

Blocking the activity of the programmed cell death protein 1 (PD-1) inhibitory receptor with therapeutic antibodies against either the ligand (PD-L1) or PD-1 itself has proven to be an effective treatment modality for multiple cancers. Contrasting with antibodies, small molecules could demonstrate increased tissue penetration, distinct pharmacology, and potentially enhanced antitumor activity. Here, we describe the identification and characterization of INCB086550, a novel, oral, small-molecule PD-L1 inhibitor. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. These data support continued clinical evaluation of INCB086550 as an alternative to antibody-based therapies.

Significance:
We have identified a potent small-molecule inhibitor of PD-L1, INCB086550, which has biological properties similar to PD-L1/PD-1 monoclonal antibodies and may represent an alternative to antibody therapy. Preliminary clinical data in patients demonstrated increased immune activation and tumor growth control, which support continued clinical evaluation of this approach.
See related commentary by Capparelli and Aplin, p. 1413.
This article is highlighted in the In This Issue feature, p. 1397
АНАЛІЗ ТЕНДЕНЦІЙ У ПРОГРАМІ РЕІМБУРСАЦІЇ «ДОСТУПНІ ЛІКИ» В УКРАЇНІ
Authors: Huz V. S. , Zaliska O. M. , Maksymovych N. M. 
Published: March 2022

Мета роботи. Провести аналіз упровадження урядової програми реімбурсації «Доступні ліки» для амбулаторного лікування основними лікарськими засобами пацієнтів із серцево-судинними захворюваннями, цукровим діабетом 2 типу та бронхіальною астмою за 2019–2020 роки.
Матеріали і методи. Об’єктами дослідження були дані з НСЗУ за 2019–2020 роки, а також Постанови КМУ, Накази МОЗ України про затвердження Реєстру лікарських засобів, вартість яких підлягає відшкодуванню у програмі «Доступні ліки». У дослідженні було використано методи частотного, порівняльного, логічного та контент-аналізу.
Результати й обговорення. Розроблено методику аналізу програми реімбурсації з урахуванням районування території України за 5 макрорегіонами та проведено аналіз таких показників, як: бюджетне фінансування програми; кількість виписаних та відпущених електронних рецептів з 01 квітня 2019 року; розподіл електронних рецептів у програмі за віком та статтю пацієнтів; структура аптек за формою власності та типом населеного пункту. Виявлено, що обсяг бюджетного фінансування програми «Доступні ліки» у 2020 році зріс у 3 рази порівняно з 2017 роком. Кількість аптек у 2020 році зросла в 1,84 раза порівняно зі стартом програми. Більшість залучених до програми аптек розташована в містах Західного та Центрального макрорегіону. Встановлено, що у 2020 році найвищі темпи приросту, за досліджуваними параметрами, зафіксовані у Південному та Західному макрорегіонах країни. Впродовж 2019–2020 років понад 50 % е-рецептів було виписано на такі міжнародні непатентовані назви (МНН): бісопролол, клопідогрель, еналаприл та амлодипін.
Висновки. Проведений аналіз програми реімбурсації виявив збільшення кількості аптек у 1,84 раза порівняно зі стартом програми у 2017 році. Згідно з регіональним розподілом та аналізом показників, найвищі показники приросту встановлені у Південному макрорегіоні. За досліджуваний період більше 50 % з усіх е-рецептів для лікування АГ було виписано для таких лікарських засобів як: бісопролол, клопідогрель, еналаприл та амлодипін.
АНАЛІЗ ІНСТРУМЕНТІВ ФОРМУВАННЯ БРЕНДУ ОСВІТНЬОЇ ПОСЛУГИ НАЦІОНАЛЬНОГО ФАРМАЦЕВТИЧНОГО
Authors: Volkova A. V. , Yakovlieva O. Yu. 
Published: March 2022

Мета роботи. Проведення аналізу інструментів формування бренду освітньої послуги Національного фармацевтичного університету за ключовими напрямами обізнаності про заклади вищої освіти (ЗВО).
Матеріали і методи. Наукові дані та нормативні документи стосовно інструментів формування бренду освітньої послуги ЗВО, анкети респондентів (здобувачів вищої освіти та потенційні вступники); використано теоретичні (аналіз наукової літератури, узагальнення, класифікації, аналітичний, порівняльний та логічний) та емпіричний (опису, порівняння) методи, а також методи дослідження бренду: психосемантичні, спрямованих асоціацій, персоніфікації; побудова карти позиціонування.
Результати й обговорення. В умовах конкуренції у сфері освіти для ЗВО значущим фактором існування на ринку є відповідність очікуванням споживачів освітніх послуг, тому на перший план виходять бренди, оскільки споживачів значною мірою привертають емоції, які вони викликають.
За результатами узагальнення даних наукової літератури було визначено напрями для аналізу інструментів формування бренду освітньої послуги. Першим етапом аналізу стало дослідження ролі корпоративної символіки у створенні бренду освітньої послуги. Другим етапом – дослідження особливостей впливу веб-сайту НФаУ на створення бренду освітньої послуги. Третій етап – вивчення впливу показників міжнародних та українських рейтингів на формування бренду освітньої послуги НФаУ. Четвертий етап – формування карти позиціонування, індивідуалізації та ідентичності бренду освітньої послуги НФаУ.
Проаналізовані інструменти і розроблені карти дали змогу виявити «точки паритету» (асоціації, які не є чимось унікальним, але володіння якими є необхідним в умовах конкурентної боротьби) і «точки диференціації» (атрибути або переваги бренду освітньої послуги, які споживачі міцно пов’язують з ним, позитивно оцінюють і вважають (вірять), що в інших брендів вони відсутні).
За підсумками проведеного аналізу інструментів формування бренду освітньої послуги НФаУ було відзначено наявність значного потенціалу ЗВО в напрямі формування обізнаності про заклад.
Висновки. У результаті проведеного дослідження зроблено висновок, що позиціонування бренду освітньої послуги дає змогу виявити місце ЗВО серед конкурентів, визначити набір потреб в освітніх послугах і їхнє сприйняття споживачами.
Досліджено роль корпоративної символіки у створенні бренду освітньої послуги НФаУ. Визначено роль та можливості отримання інформації потенційними вступниками про НФаУ із веб-сайту університету. Проаналізовано місце НФаУ в міжнародних та українських рейтингах й визначено їхній вплив на формування бренду освітньої послуги НФаУ. На основі отриманих результатів побудовано карту позиціонування, індивідуалізації та ідентичності бренду освітньої послуги НФаУ.