bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamical law of the phase interface motion in the presence of crystals nucleation
Authors: Toropova Liubov V. , Alexandrov Dmitri V. 
Published: June 2022

AbstractIn this paper, we develop a theory of solid/liquid phase interface motion into an undercooled melt in the presence of nucleation and growth of crystals. A set of integrodifferential kinetic, heat and mass transfer equations is analytically solved in the two-phase and liquid layers divided by the moving phase transition interface. To do this, we have used the saddle-point method to evaluate a Laplace-type integral and the small parameter method to find the law of phase interface motion. The main result is that the phase interface Z propagates into an undercooled melt with time t as $$Z(t)=\sigma \sqrt{t}+\varepsilon \chi t^{7/2}$$

Z

(
t
)

=
σ

t

+
ε
χ

t

7
/
2

with allowance for crystal nucleation. The effect of nucleation is in the second contribution, which is proportional to $$t^{7/2}$$

t

7
/
2

whereas the first term $$\sim \sqrt{t}$$

∼

t

represents the well-known self-similar solution. The nucleation and crystal growth processes are responsible for the emission of latent crystallization heat, which reduces the melt undercooling and constricts the two-phase layer thickness (parameter $$\chi <0$$

χ
<
0

).
Investigating the role of heat shock protein 47 in fibrosis in Crohn’s disease
Authors: Kurumi Hiroki , Takata Tomoaki , Kanda Tsutomu , Sugihara Takaaki , Kakugawa Tomoyuki , Yokota Shin-ichi , Morisaki Tomohito , Akashi Taro , Isomoto Hajime 
Published: June 2022

AbstractCrohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the gastrointestinal tract that share similar genetic risk factors. However, while fibrotic stricture of the intestine is a major characteristic of CD; it is rarely observed in UC. Deposition of collagen in the extracellular matrix contributes to the formation of fibrotic strictures in CD, but the underlying mechanisms are unknown. In the present study, we found that heat shock protein 47 (HSP47), a stress-response protein that acts as a molecular chaperone during the processing and secretion of collagen, expressed in the intestinal tissue from patients with CD. Serum HSP47 levels and anti-HSP47 antibody titers were significantly higher in patients with CD than in those with UC. Furthermore, anti-HSP47 antibody levels correlated significantly with fibrosis in CD. In addition, HSP47 inhibition significantly suppressed collagen production in fibroblasts in vitro. These findings suggest that HSP47 is a biomarker for differentiating fibrotic from non-fibrotic forms of CD. Additionally, we propose that HSP47 could be a potential target for treating fibrosis in patients with CD.
Concurrent presence of high serum uric acid and inflammation is associated with increased incidence of type 2 diabetes mellitus in Korean adult population
Authors: Lee Kyung Won , Shin Dayeon 
Published: June 2022

AbstractAlthough serum uric acid level and systemic inflammation have been highlighted as risk factors for type 2 diabetes mellitus (T2DM), little is known about these associations in the Korean population. Thus, we examined the individual and combined associations of serum uric acid and systemic inflammation (evaluated using high-sensitivity C-reactive protein [hs-CRP] measurement) with the future risk of T2DM. A total of 4152 Korean adults aged 45–76 years without T2DM, cancer, or gout at baseline in 2007–2008 from the Korean Genome and Epidemiology Study were followed up until 2016. Cox proportional hazard models were used to estimate the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of T2DM according to sex-specific tertiles of serum uric acid and hs-CRP levels after adjustment for confounders. During the mean follow-up of 7.3 years, 548 participants developed T2DM. High serum uric acid and hs-CRP levels were independently associated with an increased incidence of T2DM. The multivariable-adjusted HRs (95% CIs) for the incidence of T2DM in the highest tertiles of serum uric acid and hs-CRP were 1.54 (1.24–1.93) and 1.90 (1.48–2.43), respectively. High levels of serum uric acid and hs-CRP in combination were associated with an increased incidence of T2DM (HR: 4.69; 95% CI: 2.81–7.84) compared to low levels of serum uric acid and hs-CRP. These findings suggest that the combination of high serum uric acid and hs-CRP levels was significantly associated with an elevated incidence of T2DM; however, their synergistic effects were not observed in middle-aged and elderly Korean adults.
Cell proliferation effect of deep-penetrating microcavity tandem NIR OLEDs with therapeutic trend analysis
Authors: Park Yongjin , Choi Hye-Ryung , Jeon Yongmin , Kim Hyuncheol , Shin Jung Won , Huh Chang-Hun , Park Kyoung-Chan , Choi Kyung-Cheol 
Published: June 2022

AbstractLong wavelengths that can deeply penetrate into human skin are required to maximize therapeutic effects. Hence, various studies on near-infrared organic light-emitting diodes (NIR OLEDs) have been conducted, and they have been applied in numerous fields. This paper presents a microcavity tandem NIR OLED with narrow full-width half-maximum (FWHM) (34 nm), high radiant emittance (> 5 mW/cm2) and external quantum efficiency (EQE) (19.17%). Only a few papers have reported on biomedical applications using the entire wavelength range of the visible and NIR regions. In particular, no biomedical application studies have been reported in the full wavelength region using OLEDs. Therefore, it is worth researching the therapeutic effects of using OLED, a next-generation light source, and analyzing trends for cell proliferation effects. Cell proliferation effects were observed in certain wavelength regions when B, G, R, and NIR OLEDs were used to irradiate human fibroblasts. The results of an in-vitro experiment indicated that the overall tendency of wavelengths is similar to that of the cytochrome c oxidase absorption spectrum of human fibroblasts. This is the first paper to report trends in the cell proliferation effects in all wavelength regions using OLEDs.
Identification of a differentiation-related prognostic nomogram based on single-cell RNA sequencing in clear cell renal cell carcinoma
Authors: Xia Zhi-Nan , Wu Jing-Gen , Yao Wen-Hao , Meng Yu-Yang , Jian Wen-Gang , Wang Teng-Da , Xue Wei , Yu Yi-Peng , Cai Li-Cheng , Wang Xing-Yuan , Zhang Peng , Li Zhi-Yuan , Zhou Hao , Jiang Zhi-Cheng , Zhou Jia-Yu , Zhang Cheng 
Published: June 2022

AbstractRenal cell carcinoma (RCC) is a kidney cancer that is originated from the lined proximal convoluted tubule, and its major histological subtype is clear cell RCC (ccRCC). This study aimed to retrospectively analyze single-cell RNA sequencing (scRNA-seq) data from the Gene Expression Omnibus (GEO) database, to explore the correlation among the evolution of tumor microenvironment (TME), clinical outcomes, and potential immunotherapeutic responses in combination with bulk RNA-seq data from The Cancer Genome Atlas (TCGA) database, and to construct a differentiation-related genes (DRG)-based prognostic risk signature (PRS) and a nomogram to predict the prognosis of ccRCC patients. First, scRNA-seq data of ccRCC samples were systematically analyzed, and three subsets with distinct differentiation trajectories were identified. Then, ccRCC samples from TCGA database were divided into four DRG-based molecular subtypes, and it was revealed that the molecular subtypes were significantly correlated with prognosis, clinicopathological features, TME, and the expression levels of immune checkpoint genes (ICGs). A DRG-based PRS was constructed, and it was an independent prognostic factor, which could well predict the prognosis of ccRCC patients. Finally, we constructed a prognostic nomogram based on the PRS and clinicopathological characteristics, which exhibited a high accuracy and a robust predictive performance. This study highlighted the significance of trajectory differentiation of ccRCC cells and TME evolution in predicting clinical outcomes and potential immunotherapeutic responses of ccRCC patients, and the nomogram provided an intuitive and accurate method for predicting the prognosis of such patients.
Stronger brain activation for own baby but similar activation toward babies of own and different ethnicities in parents living in a multicultural environment
Authors: Raghunath Bindiya Lakshmi , Sng Kelly Hwee Leng , Chen S. H. Annabel , Vijayaragavan Vimalan , Gulyás Balázs , Setoh Peipei , Esposito Gianluca 
Published: June 2022

AbstractSpecific facial features in infants automatically elicit attention, affection, and nurturing behaviour of adults, known as the baby schema effect. There is also an innate tendency to categorize people into in-group and out-group members based on salient features such as ethnicity. Societies are becoming increasingly multi-cultural and multi-ethnic, and there are limited investigations into the underlying neural mechanism of the baby schema effect in a multi-ethnic context. Functional magnetic resonance imaging (fMRI) was used to examine parents’ (N = 27) neural responses to (a) non-own ethnic in-group and out-group infants, (b) non-own in-group and own infants, and (c) non-own out-group and own infants. Parents showed similar brain activations, regardless of ethnicity and kinship, in regions associated with attention, reward processing, empathy, memory, goal-directed action planning, and social cognition. The same regions were activated to a higher degree when viewing the parents’ own infant. These findings contribute further understanding to the dynamics of baby schema effect in an increasingly interconnected social world.
Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant
Authors: Campos Guilherme R. F. , Almeida Nathalie Bonatti Franco , Filgueiras Priscilla Soares , Corsini Camila Amormino , Gomes Sarah Vieira Contin , de Miranda Daniel Alvim Pena , de Assis Jéssica Vieira , de Souza Silva Thaís Bárbara , Alves Pedro Augusto , da Rocha Fernandes Gabriel , de Oliveira Jaquelline Germano , Rahal Paula , Grenfell Rafaella Fortini Queiroz , Nogueira Maurício L. 
Published: June 2022

Abstract
Background
The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination.

Methods
Based on viral microneutralization assays, we evaluated in 90 individuals the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme.

Results
Here we show that the percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 16.6% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times.

Conclusions
These results indicate a positive impact of this vaccine combination in the serological immune response against SARS-CoV-2 Omicron variant.
TTN mutations predict a poor prognosis in patients with thyroid cancer
Authors: Han Xiudan , Chen Jianrong , Wang Jiao , Xu Jixiong , Liu Ying 
Published: June 2022

Abstract
Objective: We aimed to investigate the relationship between titin (TTN) gene mutations and thyroid cancer (THCA) and to explore the feasibility of the TTN gene as a potential prognostic indicator of THCA.
Methods: From TCGA-THCA cohort, we performed a series of analyses to evaluate the prognostic value and potential mechanism of TTN in THCA. These patients were divided into the mutant-type (MUT) group and the wild-type (WT) group. Differentially expressed genes (DEGs) in the two groups were screened using the ‘DESeq2’ R package. Functional enrichment analysis was performed, and the protein–protein interaction (PPI) network, transcription factor (TF)-target interaction networks, and competitive endogenous RNA (ceRNA) regulatory networks were established for the DEGs. The TIMER database was applied for immune cell infiltration. Survival analysis and Cox regression analysis were used to analyze the potential prognostic value of the TTN gene.
Results: Differential expression analysis showed that 409 genes were significantly up-regulated and 36 genes were down-regulated. Functional enrichment analysis revealed that TTN gene mutations played a potential role in the development of THCA. Analysis of the immune microenvironment indicated that TTN gene mutations were significantly associated with enrichment of M0 macrophages. Survival analysis showed that the MUT group predicted poorer prognosis than the WT group. Cox regression analysis demonstrated that TTN gene mutations were an independent risk factor for THCA. Nomograms also confirmed the prognostic values of the TTN gene in THCA.
Conclusions In summary, our results demonstrated that TTN gene mutations predict poor prognosis in patients with THCA. This is the first study to research TTN gene mutations in THCA and to investigate their prognostic value in THCA.
E2 ubiquitin-conjugating enzymes (UBCs): drivers of ubiquitin signalling in plants
Authors: Brillada Carla , Trujillo Marco 
Published: June 2022

Abstract
Most research in the field of ubiquitination has focused on E3 ubiquitin ligases because they are the specificity determinants of the ubiquitination process. Nevertheless, E2s are responsible for the catalysis during ubiquitin transfer, and are therefore, at the heart of the ubiquitination process. Arabidopsis has 37 ubiquitin E2s with additional ones mediating the attachment of ubiquitin-like proteins (e.g. SUMO, Nedd8 and ATG8). Importantly, E2s largely determine the type of ubiquitin chain built, and therefore, the type of signal that decides over the fate of the modified protein, such as degradation by the proteasome (Lys48-linked ubiquitin chains) or relocalization (Lys63-linked ubiquitin chains). Moreover, new regulatory layers impinging on E2s activity, including post-translational modifications or cofactors, are emerging that highlight the importance of E2s.
Revisiting the V1309 Sco 2008 outburst spectra
Authors: Mason Elena , Shore Steven N. 
Published: June 2022

Context. V1309 Sco is the only confirmed non-compact stellar merger, identified thanks to the match of its pre-outburst light curve to that of a contact binary. Therefore, anything that can be deduced from existing observations may serve as benchmark constraints for models.
Aims. We present some observational evidence to guide future hydrodynamical simulations and common envelope studies.
Methods. Using archive spectra taken at high and mid spectral resolution during the V1309 Sco outburst and late decline, together with the inferential methods we developed to study nova ejecta through panchromatic high resolution spectroscopic follow ups, we constrained the physical state, structure, dynamics, and geometry of the transient that originated in the stellar merger.
Results. We found that the emitted spectra arise from two distinct contributions: matter expelled during the 2008 outburst and circumbinary gas produced during historic mass-loss episodes. These two components are likely to exhibit orthogonal geometry, with the 2008 mass loss displaying a dust-laden bipolar ejecta produced by a time limited rapidly accelerating wind and the circumbinary gas having a donut-like shape. A central source powers them both, having produced a fluorescent light pulse, but we cannot precisely determine the time it started or its spectral energy distribution. We can, however, place its upper energy cutoff at about 54 eV and the bulk of its emission at < 20 eV. We also know that the central source turned off within months after the outburst and before the ejecta turned optically thin.
Kieferorthopädische Retention bei Patienten mit parodontaler
Vorerkrankung
Authors: Hennig Christoph-Ludwig , Schulze-Späte Ulrike , Noeke Felix , Jacobs Collin 
Published: June 2022

ZusammenfassungNach Beenden der kieferorthopädischen Behandlung ist es essenziell
wichtig, das Ergebnis zu retinieren, um die erreichte Zahnposition zu
stabilisieren. Zunehmend werden erwachsene Patienten kieferorthopädisch
behandelt. Ursache der Zahnfehlstellung liegt bei diesen Patienten
häufig in einer vorangegangenen Parodontalerkrankung. Dies erfordert
teilweise ein anderes Vorgehen und Behandlungsprotokoll während der
kieferorthopädischen Therapie. Für die Retention des
kieferorthopädischen Behandlungsergebnisses werden herausnehmbare
Zahnspangen und/oder festsitzende Retainer verwendet. Die festsitzenden
Retainer bieten eine patientenunabhängige Life-Long-Retention. Eine
korrekte Retention bei Patienten mit Parodontalerkrankungen nach abgeschlossener
kieferorthopädischer Behandlung soll das Behandlungsergebnis dauerhaft
stabilisieren. So kann durch die richtige Wahl des Retentionsgerätes
durch einen Fachzahnarzt für Kieferorthopädie das
kieferorthopädische und parodontale Behandlungsergebnis stabilisiert
werden und das Voranschreiten von Parodontopathien durch eine
interdisziplinäre Zusammenarbeit vermieden werden.
Orthodontische Korrektur mit Alignerschienen im parodontal
geschädigten Gebiss
Authors: Radlanski Ralf Johannes , Dommisch Henrik 
Published: June 2022

ZusammenfassungAnhand einer orthodontischen Behandlung mit Alignerschienen nach Zahnwanderung im
parodontal geschädigten Gebiss wird diskutiert, ob mit Alignerschienen,
die mindestens 22 Stunden täglich im Mund zu tragen sind,
ungünstige Einflüsse auf die Parodontalgesundheit zu erwarten
sind. Die Literatur zeigt, dass zwar auch mit Multibracketapparaturen eine
ausreichend gute Mundhygiene erreicht werden kann, aber für die
Patienten mit Alignerschienen liegt ein Vorteil in der Tatsache, dass die
Behandlungsgeräte für eine selbstständige und
professionelle gründliche Zahn- und Mundreinigung vollständig
herausgenommen werden können. Dieser Mundhygienevorteil wird durch
Studien überwiegend bestätigt. Eine erfolgreich abgeschlossene
Therapie der Parodontitis (Stufe 1–3) ist eine uneingeschränkte
Voraussetzung für jegliche kieferorthopädische Therapie.
Umsetzungsstrategien einer diversitätssensiblen
Gesundheitsversorgung und Unternehmensführung – Eine bundesweite
postalische Befragung von Rehabilitationseinrichtungen
Authors: Aksakal Tuğba , Erdsiek Fabian , Yılmaz-Aslan Yüce , Mader Maria , Padberg Dennis , Razum Oliver , Brzoska Patrick 
Published: June 2022

Zusammenfassung
Hintergrund Verschiedene Diversitätsmerkmale, wie beispielsweise
eine Behinderung, das Geschlecht, das Alter oder ein Migrationshintergrund,
gehen mit unterschiedlichen Versorgungserwartungen und -bedürfnissen
einher. Werden diese in der Gesundheitsversorgung, einschließlich der
Rehabilitation, nicht berücksichtigt, kann das die
Versorgungszufriedenheit und den Behandlungserfolg negativ beeinflussen.
Diversitätssensibilität kann die Nutzerorientierung in der
Versorgung erhöhen und somit helfen, den vielfältigen
Versorgungsbedürfnissen und -erwartungen Rechnung zu tragen. Ziel der
vorliegenden Studie ist es zu untersuchen, welche Maßnahmen
Rehabilitationseinrichtungen in Deutschland nutzen, um eine
diversitätssensible Versorgung anzubieten und welche möglichen
Hindernisse bei der Umsetzung entsprechender Maßnahmen wahrgenommen
werden.
Methodik Zwischen Mai und August 2019 wurden Verwaltungsleitungen aller
stationären Rehabilitationseinrichtungen zur Teilnahme an einer
bundesweiten postalischen Fragebogenerhebung eingeladen (n=1233). Der
Fragebogen umfasste Fragen zum Umgang mit den Diversitätsmerkmalen von
Mitarbeitenden und Rehabilitand*innen. Es lagen Antworten von insgesamt
223 stationären Rehabilitationseinrichtungen vor (Rücklaufquote:
18,9%). Die Daten wurden deskriptiv ausgewertet.
Ergebnisse Die Einrichtungsbefragung zeigt auf, dass
Diversitätssensibilität für viele
Rehabilitationseinrichtungen ein relevantes Thema ist.
Diversitätssensibilität sei besonders von Bedeutung für
die Zufriedenheit der Versorgungsnutzer*innen, die Zufriedenheit der
Mitarbeitenden und den Behandlungserfolg von Rehabilitand*innen.
Hindernisse bei der Umsetzung einer diversitätssensiblen Versorgung
seien fehlende Anreize der Versorgungsträger, fehlende finanzielle
Ressourcen und organisatorische Schwierigkeiten.
Diskussion Die Mehrheit der befragten Verwaltungsleitungen erkennt die
Relevanz einer diversitätssensiblen Versorgung an, Instrumente zur
Umsetzung dieser kommen allerdings nur selten und unsystematisch zum Einsatz.
Zur Förderung von Diversitätssensibilität
benötigen Gesundheitseinrichtungen Unterstützung bei der
Kompetenzbildung und bei der Auswahl und Implementierung geeigneter
Maßnahmen. Eine Handreichung mit praxisnahen Anleitungen zur Umsetzung
einer diversitätssensiblen Versorgung kann hierfür eine
Grundlage bieten.
Lean Mass, Muscle Strength, and Muscle Quality in Retired Rugby
Players: The UK Rugby Health Project
Authors: Entwistle Ian , Francis Peter , Lees Matthew , Hume Patria , Hind Karen 
Published: June 2022

AbstractAlthough athletes from sports such as rugby have greater lean mass and strength
during their playing careers, little is known about these characteristics
post-retirement. Therefore, this study investigated lean mass, strength, and
muscle quality in retired elite and amateur rugby players and non-contact
athletes. Retired elite male rugby players (n=42,
43.9±10.3 y; 101.1±13.4 kg;
1.82±0.09 m), amateur rugby players (n=46,
48.0±10.5 y; 98.9±16.6 kg;
1.79±0.07 m) and non-contact athletes (n=30,
51.3±12.5 y; 91.3±13.4 kg;
1.79±0.07 m) received one total body dual-energy X-ray
absorptiometry assessment of appendicular lean mass (ALM) and ALM index (ALMI).
Grip strength was measured, and muscle quality (grip strength/unit of
arm lean mass) was calculated. Sarcopenia was identified as
ALMI<7.23 kg/m2 and handgrip
strength<37.2 kg. Total lean mass, ALM and grip strength were
greater in the elite rugby compared to amateur rugby and non-contact groups
(p<0.01). There were no significant differences in muscle quality or
sarcopenia prevalence. Retired elite rugby players had greater lean mass and
grip strength than amateur rugby and non-contact athletes, although muscle
quality was similar. The greater lean mass and strength might reflect genetic
influences or previous participation in a highly physical sport.