bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing successful university–industry collaborations: barriers and enablers deconstructed
Authors: O’Dwyer Michele , Filieri Raffaele , O’Malley Lisa 
Published: March 2022

AbstractUniversity–Industry Collaboration networks are increasingly significant to national economies. Previous studies have identified barriers and enablers of University–Industry Collaborations, however our understanding of the evolution of such collaborations is still limited thereby restricting our ability to nurture their development. This study explores the establishment of a successful University–Industry Collaboration and considers a range of perceived barriers and enablers through four emergent evolutionary phases:embryonic, initiation, engagementandestablished. The study adopted a qualitative research approach using a single site case study, focusing on the pharmaceutical industry, with 10 multinational firms and 8 academic institutions involved in a pharmaceutical collaboration. The results demonstrate that specific University–Industry Collaboration barriers and enablers emerge at different points in time, for example, strong lack of trust; strong fear of knowledge leakage, reluctance to share in the embryonic phase evolve to achieving integrity based trust and an intellectual property agreement in the engagement phase. These barriers were overcome using a range of phase appropriate mechanisms, for example, prior experience of the partners was critical in the embryonic phase, while cohesiveness and knowledge complementarity were vital in the engagement phase. The study emphasizes the significance of public funding and its distribution among members in order to support industry evolution and competitiveness. The University–Industry Collaboration continues to attract new participants and additional network-specific investments and has become a global centre of excellence for pharmaceutical research and development.
An exploratory pilot study on the involvement of APOE, HFE, C9ORF72 variants and comorbidities in neurocognitive and physical performance in a group of HIV-infected people
Authors: Zanella Isabella , Zacchi Eliana , Fornari Chiara , Fumarola Benedetta , Antoni Melania Degli , Zizioli Daniela , Quiros-Roldan Eugenia ,   the Inflammation in H. I. V. Study Group
Published: March 2022

AbstractCognitive decline of aging is modulated by chronic inflammation and comorbidities. In people with HIV-infection (PWH) it may also be affected by HIV-induced inflammation, lifestyle and long-term effects of antiretroviral therapies (ART). The role of genetics in the susceptibility to HIV-associated neurocognitive disorders (HAND) is not fully understood. Here we explored the possible relations among variants in 3 genes involved in inflammation and neurodegenerative disorders (APOE: ε2/ε3/ε4; HFE: H63D; C9ORF72: hexanucleotide expansions ≥ 9 repeats), cognitive/functional impairment (MiniMental State Examination MMSE, Clock Drawing Test CDT, Short Physical Performance Battery SPPB), comorbidities and HIV-related variables in a cohort of > 50 years old PWH (n = 60) with at least 10 years efficient ART. Patients with diabetes or hypertension showed significantly lower MMSE (p = .031) or SPPB (p = .010) scores, respectively, while no relations between HIV-related variables and cognitive/functional scores were observed. Patients with at least one APOEε3 allele had higher CDT scores (p = .019), APOEε2/ε4 patients showing the lowest scores in all tests. Patients with HFE-H63D variant showed more frequently hypertriglyceridemia (p = .023) and those harboring C9ORF72 expansions > 9 repeats had higher CD4+-cell counts (p = .032) and CD4% (p = .041). Multiple linear regression analysis computed to verify possible associations among cognitive/functional scores and all variables further suggested positive association between higher CDT scores and the presence of at least one APOEε3 allele (2,2; 95% CI [0,03 0,8]; p = .037), independent of other variables, although the model did not reach the statistical significance (p = .14). These data suggest that in PWH on efficient ART cognitive abilities and physical performances may be partly associated with comorbidities and genetic background. However, further analyses are needed to establish whether they could be also dependent and influenced by comorbidities and genetic background.
The prognostic role of ultrasound and magnetic resonance imaging in obstructive sleep apnoea based on lateral oropharyngeal wall obstruction
Authors: Molnár Viktória , Molnár András , Lakner Zoltán , Tárnoki Dávid László , Tárnoki Ádám Domonkos , Jokkel Zsófia , Kunos László , Tamás László 
Published: March 2022

Abstract
Purpose
This study examined the prognostic value of the lateral pharyngeal wall (LPW)-based obstruction and obstructive sleep apnoea (OSA) prediction using ultrasound (US) and MRI (magnetic resonance imaging).

Methods
One hundred patients with and without OSA were enrolled, according to overnight polysomnography. The LPW thickness (LPWT) was measured using a Philips Ingenia 1.5 T MRI device, and US measurements were carried out at rest and during Müller’s manoeuvre (MM) with a Samsung RS85 device. The obstruction was localised under drug-induced sleep endoscopy.

Results
Significantly greater LPWT using MRI was observed in the OSA group compared to the control group, while US results showed a significant difference only in the case of LPWT during MM on the left side. Obese patients presented significantly higher LPWT values. A significant correlation between BMI and LPWT was observed. Men presented significantly higher LPWT MRI values and left-sided LPWT using US compared to women. LPWT and AHI parameters were significantly correlated. The severity of LPW obstruction correlated with LPWT, while the LPW collapse significantly correlated with AHI. The severity of LPW collapse differed depending on the AHI values. Using US LPWT values and anthropometric parameters, a 93% effectiveness in OSA prognostication and 89% in LPWT-based obstruction were detected. MRI detected OSA in 90% and LPW-based obstruction in 84%. US successfully detected LPW-based collapse severity in 67%.

Conclusion
US LPWT measurements were helpful in detecting OSA and LPWT-based obstruction. These examinations may be useful for surgical planning.
Dynamic Analysis of A Subsea Suspended Manifold Going Through Splash Zone During Installation
Authors: Wang Ying-ying , Yang Chao , Yang Zhong-shan , Zhao Xiao-yu , Yin Jian-xi , Hu Yang-dong 
Published: March 2022

AbstractThe subsea suspended manifold designed to replace the traditional foundation structure with the buoys is a new generation subsea production system that can be suspended at a certain height from the seafloor and rapidly recycled by its own buoyancy. Due to complex environmental conditions, its hydrodynamic performance in the splash zone is extremely important for the safety of the whole installation process. In this paper, the mathematical model for the dynamic analysis of the seawater ingress process of the single-layer pre-set horizontal cabin is proposed based on the different center of gravity positions of the buoy. Meanwhile, the theoretical analysis of fiber cable is divided into infinite differential units by the discretization method, and the formulae of the horizontal displacement of the subsea suspended manifold are presented. In addition, the simulations are carried out to verify the rules of the dynamic responses on the subsea suspended manifold system with the consideration of the environmental conditions in the South China Sea. Comparing with the calculated value of the mathematical model of the cabin water ingress, the error of the simulation result by use of FLUENT is about 5.47%. Furthermore, the wave height is greater than the current impact on the lowering manifold system and the azimuth angle of the installation vessel is aligned with the direction of the environmental load.
Outcomes after implementation of prophylactic protocol for venous thromboembolism in surgical patients: A retrospective cohort study
Authors: Kittitirapong Nutsiri , Horsirimanont Suthas , Pornwaragorn Chaowanun , Tepsamrithporn Gorawee , Na Chonburi Chiraphi Soonthornkul , Gajaseni Chotip , Sonpee Chutirat , Pootracool Piyanuch 
Published: March 2022

ABSTRACT

Introduction:
Venous thromboembolism (VTE) in surgical patients is a preventable cause of hospital death. In previous studies, the prevalence of VTE decreased after implementing a prophylactic protocol. Because of the low rate of VTE prophylaxis in Thailand, we studied the outcomes after the implementation of a VTE prophylactic protocol in our hospital.

Methods:
A retrospective cohort single-center study was conducted from November 2019 to November 2020 in the Department of Surgery. We established the VTE prophylactic protocol using a multidisciplinary team approach and the Caprini score risk assessment model. The outcomes were the incidence of symptomatic VTE, VTE-related death, risk factors, and safety.

Results:
In total, 6983 patients were admitted to the surgical department during the study period. After excluding patients with current VTE and missing data, 4579 patients were enrolled in this study, and 1579 (34.5%) patients at high risk for VTE were identified. The use of pharmacological prophylaxis, mechanical prophylaxis, and early ambulation in the entire cohort was lower than that in high-risk patients (7.99%, 19.81%, and 21.56% vs. 15.77%, 31.10%, and 46.55%, respectively). In the comparison of before and after implementation, the prevalence of symptomatic VTE and 30-day mortality of VTE decreased from 1.20% to 0.37% and from 0.11% to 0.02%, respectively. No major bleeding occurred.

Conclusions:
After protocol implementation, the prevalence of symptomatic VTE and VTE-related death decreased. The VTE prophylaxis was safe. We highly recommended using a multidisciplinary team approach VTE prophylaxis in high-risk surgical patients.

Highlights
The effect of self-care training on happiness and resilience of patients undergoing coronary artery bypass graft surgeries
Authors: Molazem Zahra , Jalali Fatemeh , Jannati Mansour , Shaygan Maryam , Khademian Mohammad Hosein 
Published: March 2022

ABSTRACT

Background:
Self-care training after open-heart surgery is an effective method and nurses can reduce anxiety in patients by providing them the necessary information.

Objectives:
This study investigated the effect of self-care training on happiness in patients undergoing coronary artery bypass graft surgery.

Methods:
Data collection tools were two questionnaires, demographic information, Oxford Happiness and Connor & Davison Resilience Questionnaire (CD-RISC).

Results:
The mean score of happiness in the intervention group increased significantly one month after the intervention (57.36 ± 10.51 versus 64.50 ± 8.05, P = 0.001). The mean score of resilience in the intervention group increased significantly one month after the intervention (56.76 ± 13.00 and 66.46 ± 10.48, P = 0.01).

Conclusion:
Self-care training for patients undergoing coronary artery surgery has positive effects on their happiness and resilience. Therefore, it is necessary to pay attention to the principled and planned educational interventions. Routine and codified educational interventions in the wards are sometimes not done as they should be. It is recommended for health care delivery systems to design these training programs in the form of rehabilitation programs.

Highlights
Professional development in conservation: an effectiveness framework
Authors: Loffeld Thirza A. C. , Humle Tatyana , Cheyne Susan M. , Black Simon A. 
Published: March 2022

AbstractContemporary conservation professionals are part of a workforce focused on overcoming complex challenges under great time pressure. The characteristics of conservation work, and in particular the evolving demands placed on the workforce, mean that to remain effective these professionals need to enhance their skills and abilities continually. Currently, there are no sector-wide guidelines to promote systematic professional development that addresses both individual and organizational learning. This study builds upon existing knowledge from other sectors by examining professional development in conservation through an in-depth qualitative thematic analysis of interviews with 22 conservation professionals, resulting in an effectiveness framework for professional development in the conservation sector. Our findings indicate how individuals’ motivation to learn, proactivity, open-mindedness towards alternative information and views were considered preconditions for effective professional development. A balance between organizational goals and career ambitions was found essential to maintain this motivation to learn and vital for staff retention and preservation of institutional knowledge. Professional development plans may help distinguish between individual career aspirations and organizational objectives and aid a discussion between staff and management on how to balance the two. Leaders have the opportunity to remove barriers to effective professional development. We discuss solutions to overcome specific barriers, to promote an inclusive approach for diverse learners through provision of opportunities, effective learning design, and resource distribution for professional development. This effectiveness framework can be used by conservationists and conservation organizations to plan and decide on professional development.
The sequence of musical development and its place in Swanwick’s meta-theory of music education: a personal response
Authors: Philpott Chris 
Published: March 2022

AbstractIt can be argued that Swanwick’s research and scholarship established the field of music education as an area of interdisciplinary study in the United Kingdom. A significant and seminal publication in this legacy is Swanwick’s work with Tillman on the sequence of musical development based on Tillman’s empirical study of children’s compositions. This paper will aim to place the resulting ‘spiral’ in the wider context of Swanwick’s meta-theory of music education and to understand some of the critical issues surrounding it. The paper will conclude with an appraisal of Swanwick’s impact on the theory and practice of music education.
Ten-year-old boy with congenital long QT syndrome type 2 (LQTS2) and life-threatening electrical storm: a case report of successful treatment with mexiletine
Authors: Wåström Moa , Pfammatter Jean-Pierre 
Published: March 2022

AbstractWe present a case of a boy with long QT syndrome type 2, who was admitted after an out of hospital cardiac arrest due to ventricular fibrillation. Subsequently, all treatments – intravenous magnesium, optimisation of electrolytes, an isoproterenol infusion – failed to terminate his electrical storm. As a last option before left-sided cardiac sympathetic denervation, mexiletine was started and the electrical storm resolved completely.
Co-channel interference analysis at faulty K band waveguide joints
Authors: Sharma Neelam , Panda Debendra Kumar 
Published: March 2022

AbstractChannel interference is a significant issue for many applications such as satellite communication, mobile communication, and RADAR communication. This paper presents co-channel interference analysis at faulty K band waveguide joints using the multi-cavity modeling technique. Numerical data obtained from multi-cavity modeling technique analysis has been compared with CST microwave studio simulated data and verified with measured data.
Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1
Authors: García-Domínguez Daniel J. , Hajji Nabil , López-Alemany Roser , Sánchez-Molina Sara , Figuerola-Bou Elisabet , Morón Civanto Francisco J. , Rello-Varona Santiago , Andrés-León Eduardo , Benito Adrián , Keun Hector C. , Mora Jaume , Tirado Óscar M. , de Álava Enrique , Hontecillas-Prieto Lourdes 
Published: March 2022

AbstractEwing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying molecular mechanisms leading to EWS metastases remain poorly understood. Epigenetic changes have been implicated in EWS tumor growth and progression. Linking epigenetics and metastases may provide insight into novel molecular targets in EWS and improve its treatment. Here, we evaluated the effects of a selective G9a histone methyltransferase inhibitor (BIX01294) on EWS metastatic process. Our results showed that overexpression of G9a in tumors from EWS patients correlates with poor prognosis. Moreover, we observe a significantly higher expression of G9a in metastatic EWS tumor as compared to either primary or recurrent tumor. Using functional assays, we demonstrate that pharmacological G9a inhibition using BIX01294 disrupts several metastatic steps in vitro, such as migration, invasion, adhesion, colony formation and vasculogenic mimicry. Moreover, BIX01294 reduces tumor growth and metastases in two spontaneous metastases mouse models. We further identified the sialidase NEU1 as a direct target and effector of G9a in the metastatic process in EWS. NEU1 overexpression impairs migration, invasion and clonogenic capacity of EWS cell lines. Overall, G9a inhibition impairs metastases in vitro and in vivo through the overexpression of NEU1. G9a has strong potential as a prognostic marker and may be a promising therapeutic target for EWS patients.
Neutrophils direct preexisting matrix to initiate repair in damaged tissues
Authors: Fischer Adrian , Wannemacher Juliane , Christ Simon , Koopmans Tim , Kadri Safwen , Zhao Jiakuan , Gouda Mahesh , Ye Haifeng , Mück-Häusl Martin , Krenn Peter W. , Machens Hans-Günther , Fässler Reinhard , Neumann Philipp-Alexander , Hauck Stefanie M. , Rinkevich Yuval 
Published: March 2022

AbstractInternal organs heal injuries with new connective tissue, but the cellular and molecular events of this process remain obscure. By tagging extracellular matrix around the mesothelium lining in mouse peritoneum, liver and cecum, here we show that preexisting matrix was transferred across organs into wounds in various injury models. Using proteomics, genetic lineage-tracing and selective injury in juxtaposed organs, we found that the tissue of origin for the transferred matrix likely dictated the scarring or regeneration of the healing tissue. Single-cell RNA sequencing and genetic and chemical screens indicated that the preexisting matrix was transferred by neutrophils dependent on the HSF–integrin AM/B2-kindlin3 cascade. Pharmacologic inhibition of this axis prevented matrix transfer and the formation of peritoneal adhesions. Matrix transfer was thus an early event of wound repair and provides a therapeutic window to dampen scaring across a range of conditions.
An original approach to measure ligand/receptor binding affinity in non-purified samples
Authors: Rascol Estelle , Dufourquet Anouk , Baccouch Rim , Soule Pierre , Alves Isabel D. 
Published: March 2022

AbstractSeveral biochemical and biophysical methods are available to determine ligand binding affinities between a biological target and its ligands, most of which require purification, labelling or surface immobilisation. These measurements, however, remain challenging in regards to membrane proteins, as purification processes require their extraction from their native lipid environment, which may in turn impact receptor conformation and functionality. In this study, we have developed a novel experimental procedure using microscale thermophoresis (MST) directly from cell membrane fragments, to determine different ligand binding affinities to a membrane protein, the dopamine D2 receptor (D2R). In order to achieve this, two main challenges had to be overcome: determining the concentration of dopamine D2R in the crude sample; finding ways to minimize or account for non-specific binding of the ligand to cell fragments. Using MST, we were able to determine the D2R concentration in cell membrane fragments to approximately 36.8 ± 2.6 pmol/mg. Next, the doses-responses curves allowed for the determination of KD, to approximately 5.3 ± 1.7 nM, which is very close to the reported value. Important details of the experimental procedure have been detailed in this paper to allow the application of this novel method to various membrane proteins.
New Terpenoids from the Corticioid Fungus Punctularia atropurpurascens and their Antimycobacterial Evaluation
Authors: Acero Daniel , Khan Firoz Shah Tuglak , Medina-Ortiz Abraham J. , Rivero-Cruz Isabel , Raja Huzefa A. , Flores-Bocanegra Laura , Fajardo-Hernández Carlos A. , Wan Baojie , Franzblau Scott G. , Hematian Shabnam , Figueroa Mario 
Published: March 2022

AbstractChemical investigation of Punctularia atropurpurascens strain HM1 (Punctulariaceae), a corticioid isolated from a decorticated piece of Quercus bark collected in Bosque de
Tlalpan, Mexico City, led to the isolation of a new drimane, 1-α-hydroxy-isodrimenine (1) and a new tetrahydroxy kauranol, 16-hydroxy-phlebia-nor-kauranol (2),
together with the known N-phenylacetamide (3). Structures of all compounds were elucidated by spectroscopic and spectrometric methods, and the absolute configuration of
1 and 2 was confirmed via single-crystal X-ray crystallography. The isolated compounds showed modest antimycobacterial activity.
Assembly of the Hydroxycinnoline Core via Hydrazide-Assisted Rh(III)-Catalyzed C–H Functionalization and Annulation
Authors: Kim Suho , Park Heon Kyu , Mishra Neeraj Kumar , Kim In Su , Kang Ju Young 
Published: March 2022

AbstractThe structural modification of phthalazinones and indazolones has emerged as a pivotal topic in catalytic C–H functionalization events. Herein we report the hydrazide-assisted rhodium(III)-catalyzed cross-coupling reactions of N-arylphthalazinones and N-arylindazolones with vinylene carbonate. This method provides direct access to tetracyclic hydroxycinnolines. Complete site-selectivity and functional group compatibility were observed.
Semiconductor laser based on a CdS/ZnSe heterostructure with longitudinal optical pumping by a laser diode
Authors: Butaev M.R. , Kozlovsky V.I. , Skasyrsky Ya.K. 
Published: March 2022

Abstract
An optically pumped semiconductor laser based on a CdS/ZnSe heterostructure containing 10 coupled quantum wells is studied. The structure is grown by metalorganic vapour phase epitaxy on a GaAs substrate. A microcavity with interference dielectric mirrors is fabricated based on this structure. At room temperature under longitudinal pumping by an InGaN/GaN pulsed laser diode with a wavelength of 438 nm, the peak power of the microcavity reaches 100 mW at a wavelength of 508 nm and a pulse duration of 65 ns.
IR laser oscillation on caesium and rubidium atomic transitions upon pumping to high-lying energy levels
Authors: Babin A.A. , Volkov M.V. , Garanin S.G. , Kovaldov S.A. , Kopalkin A.V. , Starikov F.A. , Strakhov A.V. , Feoktistov V.V. 
Published: March 2022

Abstract
Laser oscillation is obtained in caesium and rubidium atoms with wavelengths in the range of 2 – 5.5 μm under pumping to high-lying energy levels. Longitudinal resonant pumping is implemented using the second harmonic of radiation from an optical parametric oscillator. The pump wavelength is tuned over discrete levels from 8P to 10P in caesium atoms and from 6P to 8P in rubidium atoms. The width of the pump radiation spectrum is 12 cm−1. When caesium atoms are pumped, the pump pulse energy is no more than 10 mJ; when rubidium atoms are pumped, it does not exceed 3 mJ. The pulse repetition rate is 10 Hz. The maximum output energy of IR laser radiation upon pumping the 9P3/2 level of caesium atoms is about 100 μJ at a cell temperature of ∼170°C, while the efficiency of pump conversion into radiation energy with a wavelength λ ∼ 3.1 μm turns out to be ∼1 %. For rubidium atoms, an estimate of the output energy of IR radiation gives a value of ∼80 μJ at a cell temperature of 180 °C, which corresponds to an energy efficiency of ∼2.7 %.