bluuebunny/crossref_metadata_2025_split huggingface dataset:
FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion
Authors: Yan Guijun , Cao Zhiwen , Yan Qiang , Zhang Mei , Zhu Yingchun , Liu Jingyu , Jiang Yue , Zhen Xin , Xu Manlin , Yue Qiuling , Zhou Jidong , Zhou Quan , Wang Xiaoying , Ding Lijun , Sun Haixiang 
Published: September 2022

Abstract
Recurrent implantation failure (RIF) is a rather thorny problem in the clinical practice of assisted reproductive technology. Due to the complex aetiology of RIF, its pathogenesis is far from fully understood, and there is no effective treatment available. Here, We explored the regulatory mechanism of the four half-domains of LIM domain 1 (FHL1), which is significantly downregulated in the endometrium of RIF patients, in blastocyst-epithelial adhesion. Indeed, FHL1 expression was dramatically increased in normal female mid-secretory endometrial epithelial cells and was abnormally reduced in RIF patients. Furthermore, FHL1 overexpression promoted blastocyst-epithelial adhesion, and interfering with FHL1 expression in the mouse uterus significantly inhibited embryo implantation. Mechanistically, FHL1 did not regulate HOXA10 mRNA expression but increased HOXA10 protein stability and activated HOXA10, thereby promoting its regulation of downstream gene expression and the β3 integrin/FAK pathway. Meanwhile, FHL1 regulates HOXA10 function by increasing HOXA10 deacetylation through enhanced binding of HOXA10 and SIRT2. SIRT2-specific inhibitors can significantly inhibit this effect. In the endometrial epithelial cells of RIF patients, the correlation between FHL1 and HOXA10 and its downstream target genes has also been verified. Finally, our data indicated FHL1 is a regulatory molecule that promotes blastocyst-epithelial adhesion. Altogether, downstream dysfunction due to aberrant FHL1 expression is an important molecular basis for embryo implantation failure in patients with RIF and to provide new potential therapeutic targets.
Leveraging on traditional practices to address contemporary healthcare inequities: a case of Kisiizi Community-based Health Insurance Scheme.
Authors: Kakama Alex Ayebazibwe , Atuheire Ambrose , Kahyana Danson 
Published: September 2022

Abstract
Engozi, a traditional health and social-services system has
existed for centuries in southwestern Uganda. Members contributed
funds for: healthcare, transport for patients to hospitals and
burial ceremonies for members. Membership focused on clanship or
neighbourhood. The establishment of “free public healthcare
services” led to the decline of the engozi system. However, due to
inadequate government resource allocation to health sector, the
government health services cannot meet the needs of the rural
communities. Equitable access to healthcare is still unachievable
even after the abolition of user fees. Cost of services is still a
key barrier, and the poor have limited access to quality healthcare
services. CBHI was fronted as one strategy to address such
inequities. In 1996, the Kisiizi community leveraged on the engozi
groups’ traditions to establish the first Community-based Health
Insurance (CBHI) Scheme in Uganda, promoting access to quality
healthcare at a low cost. CBHI has been successful in reducing
out-of-pocket payments, obtaining financial protection against
catastrophic health expenditures and improving access to healthcare
in low-income communities. The goal of this study was to explore
the significance of community values and traditions in addressing
healthcare inequities through a CBHI approach. This study adopted a
case study methodology and qualitative methods., The study was
guided by Woolcock’s social capital theory.

Conclusion: This paper affirms that communities characterized
by solid intra-community ties are more likely to experience success
with CBHI. It adds that compliance to society values and
traditions; and active involvement of community leaders in the
planning and execution of CBHI are essential determinants of
success. Consequently, the CBHI scheme addresses contemporary
healthcare inequities through; breaking financial barriers to
accessing quality healthcare, promoting early healthcare-seeking
behavior, and leads to increased equity in healthcare access and
utilization.
Susceptibility of Neohelice granulata (Decapoda, Varunidae) to White Spot Syndrome Virus (WSSV)
Authors: Moser Juliana Righetto , Marques Maria Risoleta Freire 
Published: September 2022

Abstract
White Spot Syndrome Virus (WSSV) continues to be the most severe viral pathogen to the shrimp industry worldwide. Pacific white shrimp Litopenaeus vannamei is particularly affected by WSSV and this virus has been detected in a wide range of wild crustaceans, including penaeid and non-penaeid shrimp, crayfish, as well as crabs. Crabs have been considered as a dangerous threat to shrimp farms because they are generally believed to be highly tolerant to WSSV and to remain infected for long periods without signs of disease. The burrowing crab Neohelice (= Chasmagnathus) granulata can be commonly found in the surroundings of the shrimp farms in southern Brazil. Here, we investigated the susceptibility of N. granulata to WSSV infection in comparison to L. vannamei. WSSV infectability and host susceptibility were investigated by viral challenge (intramuscular injection) in both species. Viral load in challenged animals was quantified by qPCR in both hemolymph and gills. Furthermore, the transcript levels of sixteen target genes related to the molecular defense status were assessed. The results revealed that N. granulate experimentally infected by WSSV, as well as those naturally infected, showed lethargy, lack of appetite and later gross signs of the disease. Moreover, N. granulate showed to be less susceptible to WSSV when compared to L. vannamei. While no death was observed in crabs before a post-challenge interval of 120 h; shrimp death was seen as early as 48 hours post-infection. Comparative viral load was also assessed by qPCR in gills of captured wild crabs and farmed shrimp naturally infected by WSSV. Transcript levels of target genes were also investigated after WS-challenge between 24 and 48 hpi in shrimp and between 96 and 120 hpi in crab. Differences in gene transcripts were particularly noteworthy with the increase of viral copies at 106 copies.µl− 1. These results indicated that WSSV infection modulated genes related of important cellular responses, such as apoptosis, chaperone function and ion storage, in both shrimp and crab.
Ventral and dorsal aspects of the inferior frontal-occipital fasciculus support verbal semantic access and visually-guided behavioural control
Authors: Alam Tirso RJ Gonzalez , Arias Juan Cruz , Jefferies Elizabeth , Smallwood Jonathan , Davolos Julian Marino 
Published: September 2022

Abstract
The Inferior Frontal Occipital Fasciculus (IFOF) is a major anterior-to-posterior white matter pathway in the ventral human brain that connects parietal, temporal and occipital regions to frontal cortex. It has been implicated in a range of functions, including language, semantics, inhibition and the control of action. Recent research shows that the IFOF can be sub-divided into a ventral and dorsal branch, but the functional relevance of this distinction, as well as any potential hemispheric differences, are poorly understood. Using DTI tractography, we investigated the involvement of dorsal and ventral subdivisions of the IFOF in the left and right hemisphere in a response inhibition task (Go/No-Go), where the decision to respond or to withhold a prepotent response was made on the basis of semantic or non-semantic aspects of visual inputs. The task also varied the presentation modality (whether concepts were presented as written words or images). The results showed that the strength of both dorsal and ventral IFOF in the left hemisphere were associated with participants’ inhibition performance when the signal to stop was meaningful and presented in the verbal modality. This effect was absent in the right hemisphere. The strength of dorsal IFOF was also associated with participants’ inhibition efficiency in difficult perceptually guided decisions. This pattern of results indicates that left dorsal IFOF is implicated in the domain-general control of visually-guided behaviour, while the left ventral branch might interface with the semantic system to support the control of action when the inhibitory signal is based on meaning.
Preparation of High Purity and Whiteness gypsum from Phosphogypsum for CO 2 Mineral Sequestration
Authors: Zhang Man , Fan Xing 
Published: September 2022

Abstract
Phosphogypsum (PG) is a solid waste produced in the production process of wet-process phosphoric acid. Due to the inclusion of various impurities, the purity and whiteness of PG has been greatly reduced, and the application range of phosphogypsum is also limited. This article analyzes the physical properties of PG in detail, and systematically studies the content and distribution of impurities. Based on this, a simple process to efficiently remove almost all impurities in the PG was proposed. The results showed that the purity and whiteness of the purified gypsum(CaSO4) significantly increased to 99% and 92%, respectively. The migration of impurities and the material balance of this process was analyzed. Most importently, the purified gypsum showed high CO2 sequestration efficiency for CO2 mineral sequestration and through which high value added CaCO3 product can be obtained.
Consolidation behavior of various types of slurry tailings co-disposed with waste rock inclusions: a numerical study
Authors: Nguyen Ngoc Dung , Pabst Thomas 
Published: September 2022

Abstract
The co-disposition of mine tailings and waste rock in tailings storage facilities (TSFs) could contribute to increase the consolidation rate and decrease long-term settlement of tailings. Non-linear change of tailings properties during the filling process and interaction between tailings and waste rock inclusion (WRI) are critical to mechanical analysis but can, however, be complicated to simulate. The question of net volume gains or losses of tailings was also raised. In this study, fully coupled analysis which considered continuous variation of hydraulic conductivity and stiffness of tailings were performed to assess the evolution of consolidation of various tailing types in the presence of WRI. Effects of volume ratio of tailings over WRI on the net volume was investigated. Finally, effect of several practical aspects such as filling rates, and instantaneous filling assumption were considered. Results indicated that WRI could increase by 3.3 times the rate of consolidation of tailings. The zone of influence of WRI on tailings consolidation varied for each tailings. Using updated properties showed significant differences compared to models with constant values. The application of WRI can reduce volume available for the storage of tailings and net volumetric change due to settlement of the tailings with or without WRI could be estimated explicitly. Equations predicting evolution of net volume with the changes in the volume ratio of tailings and WRI were accordingly proposed. WRI effects was more pronounced with the increase of the filling rate. Finally, instantaneous filling assumption had little effect on the simulated rate of consolidation.
Role of apelin in vascular smooth muscle cell phenotypic transition: a proatherogenic factor for atherosclerosis
Authors: Santos Luís Miguel Cardoso Dos , Azar Pascal , Brun Cécile , König Stéphane , Roatti Angela , Baertschi Alex J , Chaabane Chiraz , Bochaton-Piallat Marie-Luce 
Published: September 2022

Abstract
Background. During atherosclerotic plaque formation smooth muscle cells (SMCs) switch from a contractile/differentiated to a synthetic/dedifferentiated phenotype We previously isolated differentiated spindle-shaped (S) and dedifferentiated rhomboid (R) SMCs from porcine coronary artery. R-SMCs express S100A4, a calcium binding protein.
Aim. We investigated the role of apelin in this phenotypic conversion, as well as its relationship with S100A4.
Results. We found that apelin was highly expressed in R-SMCs compared with S-SMCs. We observed a nuclear expression of apelin in SMCs within experimentally-induced intimal thickening of the porcine coronary artery and rat aorta. Plasmids targeting apelin to the nucleus (N. Ap) and to the secretory vesicles (S. Ap) were transfected into S-SMCs where apelin was barely detectable. Both plasmids induced the SMC transition towards a R-phenotype. Overexpression of N. Ap, and to a lesser degree S. Ap, led to a nuclear localization of S100A4. Stimulation of S-SMCs with platelet-derived growth factor-BB, known to induce the transition toward the R-phenotype, yielded nuclear expression of both apelin and S100A4.
Conclusion. Apelin induces a SMC phenotypic transition towards the synthetic phenotype. These results suggest that apelin acts via nuclear re-localization of S100A4, raising the possibility of a new complex pro-atherogenic relationship between apelin and S100A4.
Treatment burden for older people with multimorbidity: a cross-sectional study in China
Authors: Dou Liyuan , Jiang Qiuling , Duncan Polly , Li Xiaoping 
Published: September 2022

Abstract
Background: There has been little research in China about treatment burden. Studies internationally have found high treatment burden is associated with number of long-term conditions, low quality of life (QoL) iand poor medication adherence. The purpose of this study is to understand factors associated with high treatment burden for older people with multimorbidity in China. Methods：A cross-sectional survey was conducted from February to May 2022. Through convenience sampling, 353 older people (≥60 years) with multimorbidity (≥2 long-term conditions) admitted to hospital in Zhengzhou, China, were invited to complete a survey including sociodemographic characteristics, long-term conditions and the Chinese version of Multimorbidity Treatment Burden Questionnaire (C-MTBQ). Ordinal logistic regression was used to identify the factors associated with high treatment burden.Results： 342 older people with multimorbidity participated (response rate 92.2%) among whom, the prevalence of no，low，medium, and high treatment burden was 1.2% (4/342)，13.9% (44/342)，49.1% (168/342)，and 36.8% (126/342), respectively. Ordinal logistic regression analysis found high treatment burden was associated with age, monthly household income，type of medical insurance，and number of long-term conditions.Conclusion：Most surveyed older people with multimorbidity experienced medium-to-high treatment burden. Interventions to reduce treatment burden for people with multimorbidity in China, should focus particularly on people at risk of higher treatment burden, namely older people with low income and high number of long-term conditions.
Photon trapping in a time cavity flying with a speed of light
Authors: Babushkin Ihar , Melchert Oliver , Morgner Uwe , Demircan Ayhan 
Published: September 2022

Abstract
A refractive index step, moving at the speed of light, can serve as a trap for weak light waves. Here we shed light on highly unusual features of such trapping, making it fundamentally different from conventional “resting” cavities. First, such trapping can be described as time-tapping rather than space-trapping. Trapping in time provides superior quality Q, but this quality does not anymore impose very narrow spectral lines, breaking thereby the fundamental time-bandwidth limit inherent to most traps of any physical nature. Although the trapped states are almost entirely disconnected from the outer world, a nonreciprocal connection channel involving resonant radiation can be opened and tunably manipulated. Nonreciprocity breaks the balance between the energy currents directed into the trap and back, allowing to load the trap faster than it is possible for reciprocal systems. Exotic, up to now unobserved in optics states such as halo states, and phenomena as anomalously huge delays in transmission occur naturally in a time trap. Beatings between the trapped-in-time modes provide a novel tool for ultrafast shaping of both spectral and temporal waveforms for arbitrary weak wavepackets, even for single photons. Altogether, this promises a highly eﬀicient platform for energy storage, pulse compression, waveform shaping and frequency conversion for ultrafast classical and quantum optics.
Diagnosis of Two-axis Cylindrical Grinder Machining Error
Authors: Roy Rohit , Chieng Wei-Hua , Wu Pei-Sheng , Chiang Chung-Ping 
Published: September 2022

Abstract
This paper attempts to develop a diagnosis method for classifying the machining error sources on the external/internal contour surfaces which are fabricated using a two-axis cylindrical grinding machine. A derivation of the contour profile to grinding wheel motion trajectory and also the grinding wheel motion trajectory to the contour profile equations has been performed. Due to the contours having a sinusoidal polynomial curve instead of a rose curve, the grinding wheel motion trajectory equation is then used to generate the NC code for the machining. The grinding wheel motion trajectory equation is needed for the synthesis of the profile error caused by the motion error as well as the variation of the grinding wheel diameter. The two-axis motion equation is obtained by transforming the non-circular contour equation through the coordinates of the grinding wheel and workpiece. The influence of different machining parameters such as grinding wheel outer diameter error, grinding wheel feed rate, workpiece rotation speed on the external/internal contour profile is being studied and analyzed. The diagnosis method is based on the least square method to assemble the components of the profile error due to each individual error sources. The actual machining with probe system is used to verify the diagnosis result.
Coal–gangue recognition via Multi–branch convolutional neural network based on MFCC in noisy environment
Authors: Jiang HaiYan , Zong DaShuai , Gao KuiDong , Song QingJun , Shao HuZhi , Liu ZhiJiang 
Published: September 2022

Abstract
This paper mainly studies the more accurate recognition of coal–gangue in the noise site environment in the process of top coal caving. Mel Frequency Cepstrum Coefficients (MFCC) smoothing method was introduced in the coal–gangue recognition site. Then, a convolution neural network model with three branches was developed. Experiments show that the proposed coal–gangue recognition method based on multi branch convolution neural network and MFCC smoothing can not only recognize the state of falling coal or gangue, but also recognize the operational state of site device.
Recent increase in the detection of human parainfluenza virus during the coronavirus disease-2019 pandemic in the Republic of Korea
Authors: Kim Heui Man , Rhee Jee Eun , Lee Nam-Joo , Woo Sang Hee , Park Ae Kyung , Lee Jaehee , Yoo Cheon Kwon , Kim Eun-Jin 
Published: September 2022

Abstract
Background: Since the onset of the coronavirus disease-2019 (COVID-19) pandemic, the prevalence of respiratory infectious diseases, particularly, the flu epidemic, has considerably decreased. The low detection rate and decreased number of specimens have hindered the implementation of the Korea Influenza and Respiratory Viruses Surveillance System (KINRESS), a sentinel surveillance system. Most patients with influenza-like illness visit the COVID-19 screening clinic; therefore, the number of samples collected in sentinel surveillance has decreased by more than 50%. Thus, the Korea Disease Control and Prevention Agency supplemented sentinel surveillance with non-sentinel surveillance by private medical diagnostic centers. We report here a delayed and unprecedented high detection of human parainfluenza virus (hPIV) in the Republic of Korea during the COVID-19 pandemic through sentinel and non-sentinel surveillance. We also examined the causes and implications of the changes in prevalence of hPIV.Methods: We collected data for 56,984 and 257,217 samples obtained through sentinel and non-sentinel surveillance, respectively. Eight viruses were confirmed using real-time reverse transcription-polymerase chain reaction (PCR) or real-time PCR. Some specimens from the sentinel surveillance were used for genetic characterization of hPIV type 3.Results: In 2020, hPIV was rarely detected; however, it was detected in August 2021. The detection rate continued to increase considerably in September and reached over 70% in October, 2021. The detection rate of hPIV3 was significantly higher in infants and preschoolers aged 0–6 years in both sentinel and non-sentinel surveillance. Detection of hPIV was delayed in metropolitan areas compared to that in suburban regions. The hemagglutinin-neuraminidase sequences of hPIV3 generated in 2021 were not distinct from those detected prior to the COVID-19 pandemic. Conclusions: The operation of non-sentinel and sentinel surveillance to monitor respiratory viruses could sensitively detect an unprecedented revival of hPIV in the Republic of Korea during the COVID-19 pandemic.
Clinical presentation, viral kinetics and management of human monkeypox cases from New Delhi, India 2022
Authors: Relhan Vineet , Sahay Rima R. , Shete Anita M. , Choudhary Aashish , Yadav Pragya D. , Sahoo BL , Brijwal Megha , Patil Deepak Y. , Kumar Suresh , PS Kannan Sabarinath , Mohandas Sreelekshmy , Abraham Priya 
Published: September 2022

Abstract

We describe the clinico-demographical, virological follow-up and management of five confirmed Monkeypox cases from New Delhi, India without any international travel history. The viral load kinetics and viral clearance was estimated in oropharyngeal swab (OPS), nasopharyngeal swab (NPS), EDTA blood, serum, urine and various lesion specimens at every fourth day of follow-up ranging from 5-24 post onset day (POD) of illness. All the five cases presented with mild to moderate grade intermittent fever, myalgia and lesions on the genitals, groins, lower limb, trunk and upper limb. Four cases had non-tender firm lymphadenopathy. No secondary complications or sexually transmitted infections were recorded in these cases except for HBV in one case. All the cases were mild and had good recovery. The high viral load was detected at POD 14 in lesion fluid, followed by lesion roof at POD 5, lesion base at POD 14, while in urine, OPS and NPS at POD 5. The MPXV DNA was detected from 5 to 24 POD. These Monkeypox cases suggests the under diagnosed monkeypox infection in the community. This emphasizes the need for active surveillance of MPXV in high-risk population such as Men having sex with men (MSM) and female sex workers (FSW).