bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Modification of Hybrid Hydrogels to Fabricate Full-Scale Construct Using Three-Dimensional Bio-Printing Process
Authors: Nelson Cartwright , Tuladhar Slesha , Habib Ahasan 
Published: August 2022

Abstract
Bioprinting for regenerative medicine has been gaining a lot of popularity in today's world. Despite being one of the rigorously studied fields, there are still several challenges yet to be solved. Geometric fidelity and mechanical complexities stand as roadblocks when it comes to the printability of the customized constructs. Exploring the rheological properties of the compositions helps us understand the physical and mechanical properties of the biomaterials which are closely tied to the printability of the filament and eventually, geometric fidelity of the constructs. To ensure the structural integrity of the constructs, viscosity enhancers such as carboxymethyl cellulose (CMC) and crosslinkers like CaCl2 and CaSO4 were used. These crosslinkers can be used before (precrosslinking) and after (postcrosslinking) the extrusion of considered compositions to investigate and compare the outcome. To do this, mixtures of CMC (viscosity enhancer), Alginate, and CaCl2 and CaSO4 (crosslinkers) were prepared at various concentrations maintaining minimum solid content (≤8%). Each composition was subjected to a set of rheological tests like flow curve for shear thinning behavior, three points thixotropic for recovery rate, and amplitude test for gelation point. Various geometric fidelity identification tests were conducted and correlated with their physical properties. Some compositions were used to fabricate large-scale constructs (in cm-scale) to demonstrate their capability. This research is a thorough investigation of compositions when they are introduced to crosslinkers and viscosity enhancers which can be crucial for the 3D printing world.
Off-Design Modeling and Operational Optimization of Trans-Critical Carbon Dioxide Heat Pumps
Authors: Gabrielli Paolo , Sansavini Giovanni , Singh Siddhant , Garcia Luis Sanz , Jacquemoud Emmanuel , Jenny Philipp 
Published: August 2022

Abstract
Industrial heat pumps, and specifically those using carbon dioxide (CO2) as a refrigerant, can play a key role in the decarbonization of the heating and cooling sector, due to their low global warming potential, toxicity and flammability. However, challenges arise when dealing with the modeling and optimization of CO2 heat pumps under different operating conditions. We address this challenge by presenting a modeling and optimization tool to predict and optimize the operation of heat pumps in off-design conditions. The tool improves on the current state-of-the-art in several ways. First, it describes a novel thermodynamic cycle, which features higher performance than conventional heat pumps. Also, it is based on a mathematical model that describes accurately the behavior of CO2 across a wide range of thermodynamic conditions, especially near its critical region, and takes into account effects of motor-cooling, leakages and performance limits. Furthermore, it maximizes the coefficient of performance (COP) of the heat pump via an accurate and computationally efficient optimization problem. The capabilities of the model are illustrated by looking at different typical heat pump applications based on real-world projects within the heating and cooling sector. Different case studies are considered, showing how the heat pump is optimally operated during the year to maximize its COP while meeting the varying boundary conditions.
Application of Computational Fluid Dynamics to the Optimization of Heat and Momentum Transfer in an Industrial Air Blast-Freezing Tunnel
Authors: Silveira Paula Giarolla , Corrêa Jefferson Luiz Gomes , Petri Júnior Irineu , da Rocha Roney Alves , Silveira Gabriel Henrique Giarolla , Lopes Guilherme Mathias 
Published: August 2022

Abstract
Forced convection is the main heat exchange mechanism in an air-blast freezing tunnel. Knowledge of the air distribution in the equipment is important for establishing the best-operating conditions. Computational techniques can be used to predict the velocity and temperature fields in such equipment. The insertion of baffles was used to change the geometry of an air-blast freezing tunnel. Various numbers of trolleys and trolley configurations were also considered. The simulations were related to the temperature variation at the beginning of the freezing process. The presence of baffles favored a better air distribution, and there was a 15% decrease in the temperature rate with time. In addition, the repositioning of the trolleys caused the air to reach temperatures similar to that of the tunnel with only one trolley, as well as demonstrating the possibility of inserting two more trolleys in the boundary conditions.
Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial
Authors: Kedia Saurabh , Virmani Shubi , K Vuyyuru Sudheer , Kumar Peeyush , Kante Bhaskar , Sahu Pabitra , Kaushal Kanav , Farooqui Mariyam , Singh Mukesh , Verma Mahak , Bajaj Aditya , Markandey Manasvini , Sachdeva Karan , Das Prasenjit , Makharia Govind K , Ahuja Vineet 
Published: August 2022

ObjectiveMicrobiome and dietary manipulation therapies are being explored for treating ulcerative colitis (UC). We aimed to examine the efficacy of multidonor faecal microbiota transplantation (FMT) and anti-inflammatory diet in inducing remission followed by long-term maintenance with anti-inflammatory diet in patients with mild-moderate UC.DesignThis open-labelled randomised controlled trial (RCT) randomised patients with mild-moderate (Simple Clinical Colitis Activity Index (SCCAI) 3–9) endoscopically active UC (Ulcerative Colitis Endoscopic Index of Severity (UCEIS)>1) on stable baseline medications in 1:1 ratio to FMT and anti-inflammatory diet (FMT-AID) versus optimised standard medical therapy (SMT). The FMT-AID arm received seven weekly colonoscopic infusions of freshly prepared FMT from multiple rural donors(weeks 0–6) with anti-inflammatory diet. Baseline medications were optimised in the SMT arm. Clinical responders (decline in SCCAI>3) at 8 weeks in both arms were followed until 48 weeks on baseline medications (with anti-inflammatory diet in the FMT-AID arm). Primary outcome measures were clinical response and deep remission (clinical—SCCAI <2; and endoscopic—UCEIS <1) at 8 weeks, and deep remission and steroid-free clinical remission at 48 weeks.ResultsOf the 113 patients screened, 73 were randomised, and 66 were included in (35—FMT-AID; 31—SMT) modified intention-to-treat analysis (age—35.7±11.1 years; male—60.1%; disease duration—48 (IQR 24–84) months; pancolitis—34.8%; SCCAI—6 (IQR 5–7); UCEIS—4 (IQR 3–5)). Baseline characteristics were comparable. FMT-AID was superior to SMT in inducing clinical response (23/35 (65.7%) vs 11/31 (35.5%), p=0.01, OR 3.5 (95% CI 1.3 to 9.6)), remission (21/35 (60%) vs 10/31 (32.3%), p=0.02, OR 3.2 (95% CI 1.1 to 8.7)) and deep remission (12/33 (36.4%) vs 2/23 (8.7%), p=0.03, OR 6.0 (95% CI 1.2 to 30.2)) at 8 weeks. Anti-inflammatory diet was superior to SMT in maintaining deep remission until 48 weeks (6/24 (25%) vs 0/27, p=0.007).ConclusionMultidonor FMT with anti-inflammatory diet effectively induced deep remission in mild-moderate UC which was sustained with anti-inflammatory diet over 1 year.Trial registration numberISRCTN15475780.
Developing crown shape model considering a novel competition index — a case for Korean pine plantation in Northeast China
Authors: Sun Yunxia , Feng Jian , Chen Dongsheng , Gao Huilin , Zou Hongtao 
Published: August 2022

Effect of neighbor tree competition on crown shape of Korean pine plantation in Northeast China was studied. A total of 48 trees aged 7–58 years were felled, and all living branches were measured. A novel neighbor competition index that considered the overlap length between subject tree and neighbor tree crowns was created and incorporated into crown shape model. The effects of neighboring competition on crown shape, largest crown radius, and inflection point were analyzed. A dummy variable approach was used to detect crown asymmetry. The crown length index (CLI) of the subject tree was selected as the best neighbor competition index, and the mean square error reduction compared with that of the basic model was 2.0% after incorporating CLI. Crown radius displayed differences in the four cardinal directions and followed the order north > west > south > east. The crown radius in four directions for different ages decreased with increasing CLI and the difference increased with increasing tree age. The competition index, which considers horizontal and vertical competition effects, can significantly improve the performance of crown shape model. Both of inflection point and largest crown radius increased with increasing of CLI; however, the Pearson correlation coefficient was not significant ( P > 0.05).
Automated Electronic Frailty Index is Associated with Non-home Discharge in Patients Undergoing Open Revascularization for Peripheral Vascular Disease
Authors: Stutsrim Ashlee E. , Brastauskas Ian M. , Craven Tim E. , Callahan Kathryn E. , Pajewski Nicholas M. , Davis Ross P. , Corriere Matthew A. , Edwards Matthew S. , Goldman Matthew P. 
Published: August 2022

Background Frailty is associated with adverse surgical outcomes including post-operative complications, needs for post-acute care, and mortality. While multiple frailty screening tools exist, most are time and resource intensive. Here we examine the association of an automated electronic frailty index (eFI), derived from routine data in the Electronic Health Record (EHR), with outcomes in vascular surgery patients undergoing open, lower extremity revascularization. Methods A retrospective analysis at a single academic medical center from 2015 to 2019 was completed. Information extracted from the EHR included demographics, eFI, comorbidity, and procedure type. Frailty status was defined as fit (eFI≤0.10), pre-frail (0.10<eFI≤0.21), and frail (eFI>0.21). Outcomes included length of stay (LOS), 30-day readmission, and non-home discharge. Results We included 295 patients (mean age 65.9 years; 31% female), with the majority classified as pre-frail (57%) or frail (32%). Frail patients exhibited a higher degree of comorbidity and were more likely to be classified as American Society of Anesthesiologist class IV (frail: 46%, pre-frail: 27%, and fit: 18%, P = 0.0012). There were no statistically significant differences in procedure type, LOS, or 30-day readmissions based on eFI. Frail patients were more likely to expire in the hospital or be discharged to an acute care facility (31%) compared to pre-frail (14%) and fit patients (15%, P = 0.002). Adjusting for comorbidity, risk of non-home discharge was higher comparing frail to pre-frail patients (OR 3.01, 95% CI 1.40-6.48). Discussion Frail patients, based on eFI, undergoing elective, open, lower extremity revascularization were twice as likely to not be discharged home.
Incompatibility Influences Cursor Placement When Pointing to Images of Cups
Authors: Phillips James G. , Van Gemmert Arend W. A. , Hughes Barry 
Published: August 2022

Objective As images are used within graphical user interfaces to signify menu selection, it is important to understand how image properties can influence cursor placement online. Background Objects have multiple dimensions that create potential ambiguity and Stroop-like confusions for the operator if a previously habitual response conflicts with the required response. Methods To examine the impact of compatibility and other contextual factors, 41 participants used a computer Mouse or touch screen to place the cursor upon images of full or empty cups that varied in size, and direction of handle. Results Cursor placements took longer using the Mouse than touch screen. Although participants were placing the cursor on images, the size of the cup, whether it was empty or full, and the handle orientation interacted in their effects upon response duration and cursor placement. The effects of cup size reversed for empty cups or those with incompatible handles. Conclusion Context can influence cursor placement. Perceived spillability influenced precision requirements, and the cup handle can serve as target or a flanking distractor. Application Image content can influence screen hotspots. As performance can change with cup spillability, this bodes well for attempts to detect intent from cursor trajectories.
Multivariate Bayesian Arm-Based Network Meta-Analysis of Pharmacological Interventions for the Treatment of Acute Bipolar Mania in Adults
Authors: Malo Palash Kumar , Bhaskarapillai Binukumar , Kesavan Muralidharan 
Published: August 2022

Background: In a network meta-analysis (NMA), multiple treatments can be compared simultaneously by aggregating pieces of evidence from direct as well as indirect treatment comparisons in different randomized controlled trials (RCTs). Conventional NMA are performed using a normal approximation approach and can be applied for arm-level binary outcome data as well. This study aimed to estimate the treatment effects within a Bayesian framework using a binomial likelihood for a multivariate NMA model. Methods: The dataset consists of 57 RCTs comparing the effect of ten pharmacological drugs and a placebo for acute bipolar mania in adults. The binary outcomes of interest were treatment response and all-cause dropouts measured three weeks from the baseline. Binomial distribution was adopted for the number of events and the probability of event occurrence modeled on the logit scale. Jeffrey’s Beta prior was considered for the heterogeneity and inconsistency of standard deviation (SD) parameters. Cholesky and spherical decomposition strategies were adopted for the between-study variance–covariance matrix. Deviance information criterion (DIC) indices were computed to determine the model fit. All results pertaining to Markov chain Monte Carlo simulations and all analyses were carried out in WinBUGS software. Results: The estimated common heterogeneity SDs were similar, and the DIC values did not provide any evidence for superiority between the two decomposition strategies. The correlation (95% credible interval) between the outcomes was estimated as −0.31 (−0.71, −0.02) and −0.37 (−0.73, −0.03) for the Cholesky and spherical decompositions, respectively. Gelman–Rubin convergence statistics were stable, and Monte Carlo errors for all the parameters were around 0.005. Overall, olanzapine, paliperidone, and quetiapine were both significantly more effective and acceptable than a placebo when both the study outcomes were considered simultaneously. Conclusions: The findings favoring olanzapine, paliperidone, and quetiapine possess an excellent concordance with the one adopted in clinical practice, and the Canadian Network for Mood and Anxiety Treatments and Royal Australian and New Zealand College of Psychiatrists guidelines recommend these as first-line drugs for treating bipolar disorder.
Racial Fairness in Precision Medicine: Pediatric Asthma Prediction Algorithms
Authors: Pennington Jordan , Rasnick Erika , Martin Lisa J. , Biagini Jocelyn M. , Mersha Tesfaye B. , Parsons Allison , Khurana Hershey Gurjit K. , Ryan Patrick , Brokamp Cole 
Published: August 2022

Purpose Quantify and examine the racial fairness of two widely used childhood asthma predictive precision medicine algorithms: the asthma predictive index (API) and the pediatric asthma risk score (PARS). Design Apply the API and PARS and evaluate model performance overall and when stratified by race. Setting Cincinnati, OH, USA. Subjects A prospective birth cohort of 590 children with clinically measured asthma diagnosis by age seven. Measures Model diagnostic criteria included sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Analysis Significant differences in model performance between Black and white children were considered to be present if the P-value associated with a t-test based on 100 bootstrap replications was less than .05. Results Compared to predictions for white children, predictions for Black children using the PARS had a higher sensitivity (.88 vs .57), lower specificity (.55 vs .83), higher PPV (.42 vs .33), but a similar NPV (.93 vs .93). Within the API and compared to predictions for white children, predictions for Black children had a higher sensitivity (.63 vs .53), similar specificity (.81 vs .80), higher PPV (.54 vs .28), and lower NPV (.86 vs .92). Conclusions Overall, racial disparities in model diagnostic criteria were greatest for sensitivity and specificity in the PARS, but racial disparities existed in three of the four criteria for both the PARS and the API.
Care Needs and Arrangements of Aging Immigrants in the United States
Authors: Ansari-Thomas Zohra 
Published: August 2022

Objectives To examine the need for and arrangements pertaining to personal care assistance among individuals 65 and older, and how life stage at migration impacts nativity differences in aging-related care. Methods Using data from the Survey of Income and Program Participation (2001, 2004, and 2008), I examine the odds of needing care assistance, who provides care assistance, and the duration of time care assistance is needed, comparing U.S.-born individuals to migrants who arrived before age 50 (“earlier-life migrants”) and those who arrived after age 50 (“later-life migrants”). Results While earlier-life migrants showed similar patterns to U.S.-born, later-life migrants showed higher care needs, were more likely to receive care from an adult child, and were particularly likely to need care for longer durations compared to U.S.-born. Discussion Aging later-life migrants have strikingly distinct care needs and arrangements, with implications for individual and family well-being, especially considering their barriers to public support.
Body Image Dissatisfaction, Depression, and Health-Related Quality of Life Amongst Indian Obese School Children: A Cross-Sectional Study
Authors: Pothiraj Pitchai , Shamal Chopade , Krishnan Vijaya 
Published: August 2022

Background: Obesity is a growing health problem across the globe. Obesity and psychological well-being have been explored in the Indian adolescent and adult population. However, their association has not been explored in Indian obese school children. Aims: The primary objective of this study is, therefore, to analyze body image dissatisfaction (BID), depression, and health-related quality of life (HRQOL) in obese and normal-weight children and to compare these factors between the 2 groups. Methods: In this cross-sectional study, 100 obese and 100 normal-weight children from Mumbai, between 10 and 12 years of age were recruited by simple random technique. The BID was assessed using Stunkard’s Silhouette Figure Rating Scale. Depressive symptoms were evaluated with the Mood and Feelings Questionnaire: Short Version and HRQOL was examined using the Pediatric Quality of Life Inventory. The statistical analysis was carried out using SPSS statistical software version 24 (SPSS Inc. Chicago, IL USA). Results: The mean body mass index of the normal-weight children was 15.76 ± 1.4 kg/m 2 and 26.62 ± 3.1 kg/m 2 for obese. All obese children demonstrated BID, 54% were depressed and only 33% demonstrated a very good HRQOL. Intergroup analysis revealed a statistically significant difference in the obese group for BID, depression, and HRQOL, where P < .05. Conclusion: Obese school children are more prone to BID, higher depressive symptoms, and poor HRQOL than normal-weight school children. Thus, it demands a multimodal approach in preventing chronic psychological related problems in obese children.
Expression of PD-L1 as a predictive marker of sensitivity to immune checkpoint inhibitors in patients with advanced biliary tract cancer
Authors: Kim Hongsik , Kim Ryul , Jo Hyunji , Kim Hye Ryeon , Hong Joohyun , Ha Sang Yun , Park Joon Oh , Kim Seung Tae 
Published: August 2022

Background: Expression of programmed death-ligand 1 (PD-L1) has been reported to correlate with response to immune checkpoint inhibitors (ICIs) in various tumor types. However, there are few data on the role of PD-L1 expression as a predictive and prognostic biomarker of sensitivity to ICIs in patients with advanced biliary tract cancer (BTC). Objectives: We evaluated the role of PD-L1 expression as a predictive and prognostic biomarker of response to ICIs in patients with advanced BTC. Design: We retrospectively analyzed data from 83 advanced BTC patients who received ICIs as second- or third-line treatment between February 2018 and April 2021. Methods: All patient data analysis included evaluation of PD-L1 expression by the combined positive score (CPS). Results: Among 83 patients, 56 (67.5%) had PD-L1 positivity (CPS ⩾ 1). The objective response rate (ORR) to ICIs was significantly higher in advanced BTC patients with PD-L1 expression compared to those without PD-L1 expression (17.8% versus 0%, p = 0.026). However, there were no significant differences in median progression-free survival (PFS; 2.9 versus 2.6 months, p = 0.330) and median overall survival (OS; 8.1 versus 6.3 months, p = 0.289) as a response to ICIs between patients with and without PD-L1 expression. Also, there were no significant differences in ORR, PFS, and OS as a response to ICIs in conjunction with a response to a prior gemcitabine plus cisplatin regimen ( p = 0.654, p = 0.278, and p = 0.302, respectively). Conclusions: The present study suggests that the expression of PD-L1 alone was not sufficient as a novel marker to select advanced BTC patients who might benefit from ICIs. Additional comprehensive studies of biomarkers that can assist in predicting BTC patient responses to pembrolizumab and/or nivolumab therapy are required.
Acute effects of exercise on pain symptoms, clinical inflammatory markers and inflammatory cytokines in people with rheumatoid arthritis: a systematic literature review
Authors: Balchin Christopher , Tan Ai Lyn , Golding Joshua , Bissell Lesley-Anne , Wilson Oliver J. , McKenna Jim , Stavropoulos-Kalinoglou Antonios 
Published: August 2022

Background: Exercise is advocated in the treatment of rheumatoid arthritis (RA). However, uncertainty around the acute effects of exercise on pain and inflammation may be stopping people with RA from exercising more regularly. Objectives: To determine the acute effects of exercise on pain symptoms, clinical inflammatory markers, and inflammatory cytokines in RA. Design: A systematic review of the literature. Data sources and methods: Five databases were searched (PubMed, Cochrane Library, CINAHL, Scopus and SPORTDiscus); inclusion criteria were studies with acute exercise, a definite diagnosis of RA and disease characteristics assessed by clinical function (i.e., disease activity score, health assessment questionnaire and self-reported pain), clinical markers associated with inflammation (i.e., c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)), and inflammatory cytokines (i.e., interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-α)). Results: From a total of 1544 articles, initial screening and full text assessment left 11 studies meeting the inclusion criteria. A total of 274 people were included in the studies (RA = 186; control = 88). Acute bouts of aerobic, resistance, and combined aerobic and resistance exercise did not appear to exacerbate pain symptoms in people with RA. Conclusion: Post-exercise responses for pain, clinical inflammatory markers and inflammatory cytokines were not different between people with or without RA. Exercise prescription was variable between studies, which limited between-study comparisons. Therefore, future investigations in people with RA are warranted, which combine different exercise modes and intensities to examine acute effects on pain symptoms and inflammatory markers. Registration: The PROSPERO international prospective register of systematic reviews – CRD42018091155.