bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing alternative methods of modelling cumulative effects of oil and gas footprint on boreal bird abundance
Authors: Leston L. , Bayne E. , Toms J. D. , Mahon C. L. , Crosby A. , Sólymos P. , Ball J. , Song S. J. , Schmiegelow F. K. A. , Stralberg D. , Docherty T. 
Published: April 2022

Abstract
ContextOil and gas activity is increasing in the western boreal forest of North America. To manage cumulative effects of this industry, a better quantification of footprint effects on wildlife is needed.ObjectivesWe used point-count surveys to evaluate how well dose-response (amount) and zone-of-impact (distance) models for seismic lines, pipelines, well sites, roads, and energy facilities predicted the abundance of 48 bird species. MethodsWe developed models for each species, evaluating the best functional forms for different footprint effects, then predicted how different model structures influenced estimates of regional population size.ResultsMost species exhibited at least one nonlinear response to footprint amount (79% of species) or distance (88%). Species associated with older coniferous forests decreased more often with footprint amount and proximity to footprint, while species associated with open lands and young forests increased with footprint amount and proximity. One-third of species strongly changed in abundance at a threshold distance from at least one footprint. Zone-of-impact models had better model fit than dose-response models for 29 of 48 species, but both model types produced similar population estimates.ConclusionsBoth zone-of-impact and dose-response models were useful for assessing cumulative effects on wildlife and mechanisms causing change. Although we did not find evidence for edge effects distinct from habitat loss or gain for songbirds in our study, zone-of-impact models can provide evidence of positive or negative edge effects for developing management buffers, while dose-response models provide important information on functional changes in bird habitat with oil and gas footprint.
Intra-operative nerve monitoring does not reduce the incidence of recurrent laryngeal nerve injury in first-time thyroid surgery when performed by an experienced thyroid surgeon
Authors: Nikolova Kristina , Newell Brian , Samad Mohammed Adeel , Asplund Martin , Ali Annis , Patel Dhaval , Pandelidis Steven K , Pandelidis Steven M 
Published: April 2022

Abstract
Background
Recurrent laryngeal nerve injury is a feared complication of thyroid surgery, carrying significant morbidity including hoarseness, dysphagia, and respiratory distress. Direct visualization of the nerve during surgery is the standard of care for preventing injury. Intra-operative nerve monitoring (IONM) is an adjunct utilized to decrease the risk of nerve injury, with rising popularity over the past two decades. At present, its exact role is controversial. Some studies advocate routine use, while others suggest that it only adds benefit to select complex cases. The present study is a single-center, retrospective analysis to determine whether the use of IONM significantly prevents injury to the recurrent laryngeal nerve during first-time thyroid surgery, as compared to the current practice of direct nerve visualization.
Methods
All patients undergoing thyroid surgery at Wellspan York Hospital and its affiliated outpatient surgical center from July 2018 until March 2021 were included in the study. For nine months of the study, IONM was routinely used for first-time thyroid surgery. For the remaining period, direct visualization alone was used for first-time surgery, and IONM was used only selectively for ipsilateral re-operative thyroid surgery. All data was acquired from The Collaborative Endocrine Surgery Quality Improvement Program, a national endocrine surgical database. We compared nerve injury rates across the three groups of patients.
Results
377 patients who had thyroid surgery were identified with a total of 591 nerves at risk for injury. Six patients suffered inadvertent nerve injury, for an injury rate of 1.02%. In the group undergoing first-time thyroid surgery with direct visualization alone, four nerves out of 450 (0.89%) were injured. In the group with IONM routinely used for first-time surgery, there was one nerve injury out of 120 (0.83%). For patients with history of previous ipsilateral endocrine surgery with selective nerve monitoring, one injury occurred in a total of 13 at-risk nerves (7.69%).
Conclusions
The use of IONM as compared to direct identification and photo documentation of the recurrent laryngeal nerve offered no significant advantage in preventing injury. Additionally, re-operative cases have higher incidence of nerve injury, and IONM may be helpful in improving safety in these cases.
Clinical and epidemiological characteristics of severe fever with thrombocytopenia syndrome in dogs: an observational study in the Republic of Korea
Authors: Han Sun-Woo , Oh Ye-In , Rim Ji-Min , Cho Yoon-Kyoung , Kim Dong-Hoo , Kang Jun-Gu , Choi Kyoung-Seong , Chae Joon-Seok 
Published: April 2022

Abstract
Severe fever with thrombocytopenia syndrome (SFTS) is a zoonotic disease with a high mortality rate for humans and cats. The clinical course and prognosis of SFTS in dogs remains unclear. In the present study, we investigated the clinical and epidemiological characteristics of SFTS virus (SFTSV) infection in dogs. All evaluated dogs exhibited an acute course and symptoms such as fever (57.1%), anorexia (57.1%), depression (42.9%), and vomiting (35.7%). Thrombocytopenia was observed in 45.5% dogs, while jaundice was not observed. C-reactive protein, alanine transaminase, and alkaline phosphatase were elevated in some cases. Viral clearance occurred within 6 to 26 days. Phylogenetic analysis revealed that the SFTSV sequences were consistent with viruses in the regions of the Republic of Korea. Given that dogs often live in close contact with humans, awareness of the clinical and epidemiological features of SFTS in dogs is crucial. Further large-scale studies are necessary to investigate SFTSV infection in dogs.
Dating dirty speleothems using paleomagnetism
Authors: Sánchez-Moreno Elisa M. , Font Eric , Pavón-Carrasco F. Javier , Dimuccio Luca A. , Hillaire-Marcel Claude , Ghaleb Bassam , Cunha Lúcio 
Published: April 2022

Abstract
The U-series dating of young and dirty speleothems is challenging due to difficulties in assessing the isotopic composition of contaminating detrital fractions and the low- abundance of the in situ-generated 230Th. Here we propose a new dating approach based on the comparison of magnetic directions recorded by speleothems with reference curves from global paleomagnetic reconstructions. The studied stalagmite was collected in the Soprador do Carvalho cave, in the Central Region of Portugal. The radiometric age model, built using four U-series ages and three 14C, suggests relatively steady carbonate precipitation from ~ 5760 BCE until ~ 1920 CE. Forty-five, 6 mm-thick, subsamples were submitted to alternating field and thermal demagnetization, providing well-defined, primary magnetic directions. An archaeomagnetic age model of the stalagmite was obtained by fitting its paleomagnetic record with the reference paleosecular variation curves obtained by previous paleo-reconstruction models, applying statistical bootstrapping analysis to define their best fit. The resulting archaeomagnetic age models fit closely with the radiometric age model but provide a significantly higher time resolution. We reach the same conclusion when applying this approach to another stalagmite from the Algarve region of Portugal. Archaeomagnetic age models thus appear a promising alternative to date dirty speleothems.
Sexual and Reproductive Health Care Experiences and Perceptions of Women with Congenital Heart Disease
Authors: Stokes Natalie , Stransky Olivia M. , West Shawn C. , Hoskoppal Arvind , Talabi Mehret Birru , Kazmerski Traci M. 
Published: April 2022

Abstract
Due to medical advances, women with congenital heart disease (CHD) are living longer, healthier lives and many are considering pregnancy. The hemodynamic changes of pregnancy present high risks of morbidity and mortality for many women with CHD. As little is known about these women’s reproductive health experiences, this study explores their perceptions of pregnancy and family planning care as related to CHD. Women ages 18–45 years with a diagnosis of CHD associated with a World Health Organization (WHO) classification II-IV for pregnancy morbidity and mortality participated in individual, semi-structured interviews exploring their experiences, attitudes, and preferences toward parenthood, pregnancy, contraception and family planning care provision. Interviews were audio-recorded, transcribed verbatim. Two independent coders performed analysis using deductive and inductive coding approaches. Twenty women with CHD participated in interviews (average age 30.1 years, SD 5.85). Nine women had a prior pregnancy and 14 considered becoming a parent in the future. We identified 5 key themes among the women: (1) CHD impacted their reproductive health goals and decisions; (2) Women with CHD perceived a lack of safe contraceptive methods for their condition; (3) Women desired tailored, disease-specific sexual and reproductive health (SRH) information; (4) Women viewed their cardiologist as the primary source for SRH information and prefer provider-initiated discussions starting in adolescence; and (5) Women desire coordinated pre-pregnancy and intrapartum care between their cardiologists and women’s health providers. These results provide a foundation for interventions to improve patient-centered interdisciplinary reproductive healthcare for this population.
Effect of Alcalase modification of yellow lupin (Lupinus luteus L.) protein isolate on some functional properties and antioxidant activity
Authors: TESAROWICZ Iwona , MACIEJASZEK Ireneusz , SURÓWKA Krzysztof , ZAWIŚLAK Agnieszka 
Published: April 2022

Abstract
Protein isolate obtained from sweet yellow lupin (Lupinus luteus L.) and its Alcalase hydrolysates were examined for their functional and antioxidant properties in relation to surface hydrophobicity of proteins and peptides, and molecular weight distribution. Enzymatic hydrolysis improved the foaming characteristics of lupin proteins, while the emulsifying properties deteriorated. It means that good foaming properties of preparations are determined by the presence of low-molecular δ conglutin and small subunits of γ conglutins. In turn, larger proteins such as α and β conglutin are responsible for maintaining good emulsifying properties. The measured surface hydrophobicity was consistent with the results of emulsifying properties. It has also been shown that the scope of changes in antioxidant properties due to hydrolysis, measured by DPPH method and as reducing power, is more pronounced than with the use of ABTS and FRAP methods.
Salinity distribution pattern induced tomato roots capable of enhancing plant adaptability to salt stress
Authors: Wang Weihua , Gong Yidan , Cheng Bei , Ou Roucheng , yang ting 
Published: April 2022

Abstract
Salinity is a major abiotic stress threatening tomato production. Roots can attenuate salt stress in a specific salinity concentration, especially with non-uniform salinity distribution conditions are hypothesized to play a role in enhancing tomato plant adaptability to salt stress. However, it is still unclear whether and how root alleviate stress when challenged by salinity distribution. In this study, we set different salinity distribution pattern: uniform salinity distribution (T1(0, 0), T2(0.2%, 0.2%), T3(0.3%, 0.3%)) and non-uniform salinity distribution (T4(0.1%, 0.3%), T5(0.1%, 0.5%), T6(0.2%, 0.4%)), each salinity distribution employed with three levels of concentration, hydroponics method, splitting the roots into left and right parts, and observing whole growth stage. Plant physiological indices responses to salt stress were measured. Studies have indicated that tomato plant roots can attenuate salt stress in a salinity concentration with 0.4%, the non-uniform salinity distribution is capable of restricting the root-uptake, and the uptake efficiency of nutrients (Na+, K+) fruit yield, fruit flavor and quality were enhanced by non-uniform salinity distribution with certain concentration (T4(0.1%, 0.3%)). Moreover, the increased K+ lead to the decrease of the Na+/K+ ratio, which could reduce the toxicity of salt ion to the plant, and consequently improve the growth of tomato. This research confirms the critical role of salinity distribution in a specific concentration in enhancing tomato plants adaptability to salt stress, providing an overview of the prospects and restriction of nutrients application method to minimize the negative effects of salinity stress.
An evaluation of postmarketing reports of hyperglycaemia associated with dolutegravir for treatment of HIV in Eswatini
Authors: Duga Alemayehu L. , Magongo Sibongile , Nhlabatsi Siphesihle , Ladwar Denis O. , Härmark Linda , Rolfes Leàn 
Published: April 2022

Abstract
Background: Dolutegravir (DTG) is an Integrase Strand Transfer Inhibitor (INSTI) indicated in combination with other antiretroviral agents for the treatment of HIV infection. It is available in a number of pharmaceutical preparations including the fixed-dose combination (TLD)containing tenofovir (300mg) + lamivudine ( 300mg) + dolutegravir (50mg). In 2018, Eswatini adopted TLD as the preferred first-line HIV treatment regimen for adults and adolescents as per WHO recommendations. From March 2019 to March 2020, the National Pharmacovigilance Center (NPC) in Eswatini received eight reports of hyperglycaemia associated with the use of DTG. Method: A review and analysis of Pharmacovigilance reports identified from the Eswatini national pharmacovigilance database from March 2019 (introduction of DTG) to March 2020. All reports with DTG containing regimen and suspected Adverse Event of hyperglycaemia in the period of March 2019 to March 2020 were included in the study.Results: Seven of the reports were serious (resulted in hospitalization and one case concerned optic neuritis, leading to blindness). Two patients had a medical history of diabetes while the rest of the patients had never experienced hyperglycaemia before. For all the reports, the time to onset of hyperglycaemia ranges from 2-5 months after the initiation of DTG. None of the patients discontinued the use of DTG. All the patients were treated with oral hypoglycaemic medication. In severe cases, patients were treated with intravenous normal saline and ringer lactate as well as rapid-acting insulins. All patients are currently stable on oral hypoglycaemic drugs. Conclusion: Based on these findings it is recommended that healthcare professionals (HCPs) actively screen all patients for risk factors of hyperglycaemia before DTG initiation. In addition, it is important that HCPs are aware of the possible association between DTG and hyperglycaemia.
Citation analysis of the 100 top-cited articles on diskectomy via endoscopy since 2011 using Alluvial diagrams: Bibliometric analysis
Authors: Yeh Chao-Hung , Chien Tsair-Wei , Chou Po-Hsin 
Published: April 2022

Abstract
Background
Percutaneous endoscopic lumbar discectomy (PELD) is synonymous with percutaneous endoscopic transforaminal discectomy (PETD) and percutaneous endoscopic interlaminar discectomy (PEID). PEID has gained increasing recognition for its small incision, quick recovery, short hospital stay, and equivalent clinical outcome to open surgery. Numerous articles related to PEID have been published in the literature. However, which countries, journals, subject categories, and articles have ultimate influence remains unknown. The study aimed to (1) display influential entities in 100 top-cited PEID-related articles (T100PEID) on the Alluvial diagram and (2) investigate whether medical subject headings (i.e., MeSH terms) can be used to predict article citations.
Methods
T100PEID data can be found since 2011 in the PubMed and Web of Science (WOS) databases. Using Alluvial diagrams, citation analysis was conducted to compare the dominant entities. We used social network analysis (SNA) to classify MeSH terms and research areas extracted from PubMed and WOS. The difference in article citations across subject categories and the predictive power of MeSH terms on article citations in T100 PEID were examined using one-way analysis of variance (ANOVA) and regression analysis.
Results
A total of 81% of T100PEID is occupied by the top three countries (the US, China, and South Korea). There was an overall T100PEID impact factor of 41.3 (IF = citations/100). Articles were published in Spine (Phila Pa 1976) (23%; IF = 41.3). Six subject categories were classified using the SNA. The most cited article authored by D Scott Kreiner from Ahwatukee Sports and Spine in the US state of Phoenix had 123 citations in PubMed. The network characteristics of T100PEID are displayed on the Alluvial diagram. No difference was found in article citations among subject categories (F = 0.813, p = 0.543). The most frequently occurring MeSH term was surgery. MeSH terms were evident in the prediction power of the number of article citations (F =15.21; p <0 .001).
Conclusion
We achieved a breakthrough by displaying the T100PEID network characteristics on the Alluvial Plateau. The MeSH terms can be used to classify article subject categories and predict T100PEID citations. The Alluvial diagram can be applied to bibliometrics on 100 top-cited articles in future studies.
Comprehensive analysis reveals a CTHRC1-based fourteen-gene signature for prognosis prediction in colon cancer
Authors: Jianwei Wang , Xu Miaorong , Mu Jiayi , Chen Yiquan , Mu Yali , Ye Xun , Zhou Qin 
Published: April 2022

Abstract
Background: Colon cancer is a malignant gastrointestinal tumor and is still a worldwide leading cause of cancer-related mortality. Owing to the development of high-throughput sequencing technologies, large-scale data have become available in public databases. We devoted to construct and validate a gene signature that can predict patients’ outcomes for colon cancer using bioinformatics methods. Methods: We integrated GSE44076 and GSE39582 to identify differentially expressed genes (DEGs). Timer 2.0 was used to analysis CTHRC1 expression in various types of cancer. The relationship of clinicopathological features and CTHRC1 expression was explored based on TCGA database. Hub genes were identified by String database and Cytoscape software. The gene prognostic signature was established based on the Cox regression analysis.Results: We obtained 170 common DEGs and confirmed CTHRC1 was significantly overexpressed in colon cancer samples (P < 0.001). High CTHRC1 level was associated with advanced stage and shorter overall survival (OS) time and relapse-free survival (RFS) time in colon cancer patients. We identified thirteen hub genes among 516 genes co-expressed with CTHRC1 and subsequently constructed a 14-gene risk signature, which associated advanced stage and poor OS (log-rank test p < 0.01). Multivariate Cox regression indicated that high risk score was an independent risk factor for poor prognosis (p < 0.01). Finally, Receiver operating characteristic curve analysis was performed to further confirm the validity of the signature. Conclusions: We confirmed the important role of CTHRC1 in colon cancer and further constructed a 14-gene risk signature with promising prognostic accuracy for colon cancer patients.
A prospective study of Daikenchuto on superior mesenteric artery and portal venous blood flows in extremely low birthweight infants
Authors: Watanabe Shunsuke , Inoue Mikihiro , Miyata Masafumi , Boda Hiroko 
Published: April 2022

Abstract
Background: Focal intestinal perforation (FIP) is a devastating complication of prematurity, and extremely low birthweight (ELBW) infants are at highest risk. The aim of this study was to evaluate the relationship between superior mesenteric artery (SMA) and portal venous (PV) blood flow velocities to investigate the association between FIP and intestinal blood flow. In addition, Daikenchuto (TJ-100) is expected to have the effect of improving intestinal blood flow disorders, so we evaluated the effect.Methods: We conducted a prospective cohort study of 15 ELBW infants from January 2020 to August 2021.15 infants were divided the non-surgery group (Group I; 6), the surgery group with FIP (Group II; 4), and the TJ-100 administration group (Group III; 5). Main outcome parameters included SMA blood flow velocity and PV blood flow velocity.Results: A statistically significant difference was observed between the Group I and Group III on gestational age (p = 0.03). On the longitudinal evaluation of SMA and PV blood flow, statistically significant differences were found in SMA of Group I, and SMA and PV of Group III (p < 0.01, p = 0.01 and p = 0.0.4, respectively). And there was a correlation between SMA and PV in Group III (p = 0.03).Conclusion: TJ-100 may increase SMA and PV blood flow, and improve intestinal blood flow in ELBW infants at the risk of FIP. Therefore, we will continue to study the effect of TJ-100.
Differential gene screening and bioinformatics analysis of epidermal stem cells and dermal fibrblasts during skin aging
Authors: Hu Weisheng , Jing Yuan , Yu Qingqian , Huang Ning 
Published: April 2022

Abstract
Objective
To explore the differentially expressed genes (DEGs) and potential therapeutic targets of skin aging in GEO database by bioinformatics methods.
Methods
Dermal fibroblasts and skin aging related data sets GSE110978 and GSE117763 were downloaded from GEO database, and epidermal stem cells and skin aging related data sets GSE137176 were downloaded. GEO2R was used to screen DEGs of candidate samples from the three microarrays, GO function analysis and KEGG pathway analysis were performed. Protein interaction network was constructed using String database, and hub gene was obtained by Cytoscape. NetworkAnalys was used to analyze the coregulatory network of DEGs and MicroRNA (miRNA), interaction with TF, and protein-chemical interactions of DEGs. Finally, DSigDB was used to determine candidate drugs for DEGs.
Results
Six DEGs were obtained. It mainly involves the cytological processes such as response to iron ion, and is enriched in mineral absorption and other signal pathways. Ten genes were screened by PPI analysis. Gene-miRNA coregulatory network found that Peg3 and mmu-miR-1931 in DEGs were related to each other, and Cybrd1 was related to mmu-miR-290a-5p and mmu-miR-3082-5p. TF-gene interactions found that the transcription factor UBTF co-regulated two genes, Arhgap24 and Mpzl1. Protein-chemical Interactionsa analysis and identification of candidate drugs show results for candidate drugs.
Conclusion
Try to explore the mechanism of hub gene action in skin aging progression, and to discover the key signaling pathways leading to skin aging, which may be a high risk of skin aging.