bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology and Breeding Behavior of Colchicine-Induced Polyploid Impatiens spp. L.1
Authors: Arisumi Toru 
Published: August 2022

Abstract
Experiments using 2 methods of treating Impatiens with colchicine showed that 10-36% of seedlings treated soon after germination and 33-50% of colchicine treated cuttings developed stable polyploids. Most of the stable polyploids were complete tetraploids. Periclinal cytochimeras and octoploids were also isolated. Tetraploids of the inbred cultivars Blaze, Dwarf Bright Rose, General Guisan, Pinkie, and F1 hybrid White Imp, 2 interspecific hybrids between New Guinea and Java spp., 2 New Guinea hybrids, and 2 clones of a Java sp. were isolated and compared with diploids for differences in morphology and fertility. Tetraploids were larger than diploids. With certain exceptions, tetraploids had greater percentages of abortive pollen and less fertility than the diploids. Sterile diploid hybrids of ‘New Guinea’ X ‘Java’ were made fertile by tetraploidy. New Guinea 13 (2n = 64) did not cross with ‘New Guinea’ hybrid diploids (2n = 32), but it crossed readily with the ‘New Guinea’ hybrid tetraploids (4n = 64). The octoploids were sterile and ornamentally inferior to diploids or tetraploids.
Competitive adsorption of Cu2+, Pb2+, Cd2+, and Zn2+ onto water treatment residuals: implications for mobility in stormwater bioretention systems
Authors: Duan Runbin , Fedler Clifford B. 
Published: August 2022

Abstract
The lack of knowledge regarding competitive adsorption of heavy metal ions onto water treatment residuals has been hindering their reuse as a medium in stormwater bioretention systems. Competitive adsorption of copper(II), lead(II), cadmium(II), and zinc(II) onto polyaluminium chloride and anionic polyacrylamide water treatment residuals (PAC-APAM WTRs) was evaluated with different pH, temperature, initial concentration, and time. The competitive adsorption removal increased with the increase of pH and temperature. The analysis of the ratios of maximum adsorption capacity of a heavy metal ionic species in a multi-component system to that in a mono-component system (Qmix/Qmono) demonstrated that the coexisting ion had a negative effect on the adsorption of a metal ionic species. The Langmuir model provided a better fit, indicating that the adsorption could be a monolayer adsorption process. The modified Langmuir isotherm studies showed that the affinity order in the multi-component systems was Cu2+&gt;Pb2+&gt;Cd2+&gt;Zn2+. The pseudo-second-order model better described the adsorption kinetics implying that the competitive adsorption behavior could be interpreted by diffusion-based mechanisms. This study contributed to a better understanding the mobility of those frequently occurring heavy metal ions in stormwater runoff in the PAC-APAM WTRs media layer of stormwater bioretention systems.
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery
Authors: Mohi-ud-Din Roohi , Mir Reyaz Hassan , Mir Prince Ahad , Banday Nazia , Shah Abdul Jalil , Sawhney Gifty , Bhat Mudasir Maqbool , Batiha Gaber E. , Pottoo Faheem Hyder 
Published: August 2022

Abstract:Epilepsy is a chronic neurological disorder affecting 70 million people globally. One of the fascinating attributes of brain microvasculature is the (BBB), which controls a chain of distinct features that securely regulate the molecules, ions, and cells movement between the blood and the parenchyma. The barrier's integrity is of paramount importance and essential for maintaining brain homeostasis, as it offers both physical and chemical barriers to counter pathogens and xenobiotics. Dysfunction of various transporters in the (BBB), mainly ATP binding cassette (ABC), is considered to play a vital role in hampering the availability of antiepileptic drugs into the brain. ABC (ATP-binding cassette) transporters constitute a most diverse protein superfamily, which plays an essential part in various biological processes, including cell homeostasis, cell signaling, uptake of nutrients, and drug metabolism. Moreover, it plays a crucial role in neuroprotection by out-flowing various internal and external toxic substances from the interior of a cell, thus decreasing their buildup inside the cell. In humans, forty-eight ABC transporters have been acknowledged and categorized into subfamilies A to G based on their phylogenetic analysis. ABC subfamilies B, C, and G, impart a vital role at the BBB in guarding the brain against the entrance of various xenobiotic and their buildup. The illnesses of the central nervous system have received a lot of attention lately Owing to the existence of the BBB, the penetration effectiveness of most CNS medicines into the brain parenchyma is very limited (BBB). In the development of neurological therapies, BBB crossing for medication delivery to the CNS continues to be a major barrier. Nanomaterials with BBB cross ability have indeed been extensively developed for the treatment of CNS diseases due to their advantageous properties. This review will focus on multiple possible factors like inflammation, oxidative stress, uncontrolled recurrent seizures, and genetic polymorphisms that result in the deregulation of ABC transporters in epilepsy and nanotechnology-enabled delivery across BBB in epilepsy.
Reversible Photo-switching of G‐Quadruplex by Backbone-Inserted
Azobenzene
Authors: Kou Bo , Huai Xu , Xiao Jiaying , Wang Zhichao 
Published: August 2022

Introduction:
Taking the typical human telomeric G-quadruplex (G4) sequence as a reference, we designed four photoresponsive DNA sequences by inserting azobenzene moieties into a planar interlayer and the end surfaces of the G4 structure.

Method:
The photo-responsive G4 molecules were investigated by melting curve, FRET, CD, and gel electrophoresis.

Results and Discussion:
The measurements showed that the photo-responsive G4 molecules took the stable four-strand structure under visible light, but after UV light irradiation the G4 structures tended to be disentangled. When azobenzene molecules were inserted at the end surfaces of the G4 structure, the Tm difference of the photo-responsive G4 between visible light and UV light reached more than 30 oC.

Conclusion:
In a temperature range from 20 to 53 oC, the reversible transformation of the G4 structure can be realized solely by light irradiation.
Update on Oxytocin, Phosphodiesterase, Neurokinin, Glycine as a Therapeutic Approach in the Treatment of Schizophrenia
Authors: Doshi Gaurav , Bhatia Nirav , Ved Hemen , Pandya Aditya , Kulkarni Duttraj , Naik Janhavi , Bandiwadekar Tejal , Godad Angel , Kale Pravin 
Published: August 2022

Background:Schizophrenia is a chronic psychiatric disorder characterized by disrupted thoughts, perception, mood, and behavior. It has a heterogeneous genetic and neurobiological background and affects about 0.5–1% of the adult population worldwide. Herein, we review the current approaches and advances in schizophrenia. The potential therapeutic compounds for the treatment of schizophrenia act on the oxytocin receptor, phosphodiesterase system, neurokinin receptor, and glycine transport 1 receptor. Therefore, this article provides an update on the pharmacology of different receptors in addition to the dopaminergic system. These findings would guide the readers on novel targets for schizophrenia with the potential to be therapeutic agents in the future.Objective:To provide the researchers an update into the emerging role of oxytocin, phosphodiesterase, neurokinin, glycine which can be explored as potential pharmacotherapeutic targets in the treatment of schizophrenia.Methods:An extensive literature search was conducted using PubMed, Science Direct, and NCBI with the following keywords: schizophrenia, novel receptors, oxytocin, phosphodiesterase, neurokinin, and glycine. Furthermore, in order to provide insights to newer drug treatments in Schizophrenia, Furthermore, Clinicaltrials.gov website was searched for newer receptor-based drugs.Results:Current literature supported with preclinical and clinical provides substantial evidence that oxytocin, phosphodiesterase, neurokinin, and glycine play a crucial role in Schizophrenia.Conclusion:Our findings indicate that though multiple antipsychotic drugs are prescribed to treat schizophrenia, novel approaches and/or mechanisms are plausible. Moreover, sensitive and specific diagnostic tools and safe and effective interventions, including novel therapeutic agents, are required to yield substantially improved future outcomes.
Calcium-Regulating Hormonal System and HMGB1 in Cardiomyopathies
Authors: Ter-Markosyan Anna S. , Harutyunyan Knarik R. , Abrahamyan Hermine T. , Adamyan Satenik H. , Mkrtchian Souren 
Published: August 2022

Background:
Calcium ions play a key role in the heart's functional activity. The steadystate
levels of calcium are contingent on the calcium regulating hormonal system, impairment of
which might result in the development of cardiac pathology. An important role in these processes is
also attributed to the specific inflammatory mediator, HMGB1, one of the damage-associated molecular
patterns (DAMPs) released by immune cells or cell damage.

Objective:
This study investigated the cardioprotective potential of the calcium-regulating hormonal
system in cardiomyopathies with an emphasis on the possible role of HMGB1.

Methods:
Ca2+ and inorganic phosphate levels were determined in the serum using an electrolyte
analyzer and spectrophotometric analyzer correspondingly. The 1-34 fragment of parathyroid hormone
(PTH), calcitonin, vitamin D, and HMGB1 were detected using ELISA kits.

Results:
The levels of PTH, calcitonin, phosphate, and HMGB1 were found elevated in females suffering
from cardiomyopathy. The same tendency was observed in men; however, statistically significant
changes were registered only for PTH and phosphate.

Conclusion:
It can be suggested that among other reasons, the decrease of the left ventricular function
in cardiomyopathy patients can be linked to the high HMGB1, whereas the activation of the calciumregulating
system as manifested by the elevated PTH aims at restoration of calcium homeostasis and
thus have positive, i.e. cardioprotective consequences.
Physicochemical Properties, Antioxidant and Antimicrobial Activities of Sweet Orange (Citrus sinensis L. OSBECK) Fruit Peel and Pulp Oil Extracts
Authors: Sado Muhammednur , Yusuf Zekeria , Desta Mulugeta , Idris Megersa 
Published: August 2022

Background:Citrus sinensisL., commonly called sweet orange, fruit waste (peel, seed, and pulp) oils, are used as natural preservatives due to their broad spectrum of biological activities, including antimicrobial and antioxidant effects.Objective:The aim of this study was to investigate the physicochemical properties, antioxidant and antimicrobial activities of sweet orange peel and pulp oils extracted using the solvent extraction method.Methods:The oil extraction was done in the Soxhlet apparatus using petroleum ether as a solvent. Then, the physicochemical properties of the oil extracts were assessed based on the determination of oil yield, acid value, free fatty acid, and peroxide value. The antioxidant activity of the oil extract was evaluated based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), and hydrogen peroxide free radical scavenging activity as well as ascorbic acid content.Results:The results indicated that significantly higher antioxidant activities with respect to ascorbic acid (47.94%) and DPPH value 85.20% were recorded for sweet orange pulp/juice oil. Stronger antibacterial activity with a maximum zone of inhibition (10.67mm), minimum inhibitory concentration (MIC) of 0.25µg/ml, and minimum bactericidal concentration (MBC) of 0.25µg/ml were recorded for fruit pulp oil extract againstStaphylococcus aureus. Stronger antifungal activity with a maximum zone of inhibition (9.67mm), MIC (0.25µg/ml), and minimum fungicidal concentration (MFC) of 0.50µg/ml were also observed for fruit pulp oil extract againstAspergillus versicolor.Conclusion:C. sinensisfruit pulp oil was found to demonstrate stronger biological activities, including both antioxidant and antimicrobial potentials.
Mathematical Model Research on the Influence of Fluid Parameter
Characteristics on the Solid Fluidization Exploration Process of Hydrate
Reservoir
Authors: Tang Liang , Liu Yang 
Published: August 2022

Objective:
In order to further study the characteristics of flow parameters in the wellbore during
solid fluidization drilling, based on the physical model of solid fluidization exploration of hydrate
reservoir, a gas-liquid-solid three-phase flow model is established during the drilling process.

Methods:
The parameter changes of wellbore pressure, section gas holdup, liquid volume fraction, temperature
and wellbore hydrate decomposition rate under the influence of different wellhead choke pressure,
displacement and drilling fluid density during solid fluidization are analyzed.

Results:
The analysis results of the case will show that under different wellhead choke pressures, hydrate
begins to decompose at 400m to 500m, and with the increase in wellhead choke pressure, the
wellbore pressure and the volume fraction of liquid and solid phase at the same position increase significantly,
and the gas production rate and the gas volume fraction decrease. The results also show that under
different drilling fluid rates, hydrate begins to decompose at 500m to 550m, and with the increase in
drilling fluid rate, bottomhole pressure and wellbore temperature increase, the situation of hydrate decomposition
becomes better, and gas volume fraction decreases.

Conclusion:
With the increase of drilling fluid density, hydrate begins to decompose at 500m to 600m,
the wellbore temperature increases, and the hydrate decomposition is delayed. Meanwhile, the difference
in the location of hydrate decomposition becomes smaller.
Investigation on the Stability of an Electric Power Circuit under
Ferroresonance Based on Nonlinear Dynamic Model of Transformer
Authors: Pal Rajat Shubhra , Roy Madhab 
Published: August 2022

Background:
Ferroresonance is a complex electrical phenomenon, which has long been
considered a problem for power utilities. Besides, founding mitigation techniques, researchers have
also devoted their efforts to predicting the occurrence of ferroresonance in susceptible networks.
The study requires mathematically suitable transformer models for computer simulations.

Objective:
The objective of this paper is to study ferroresonance and examine the stability of the
system when source voltage changes gradually from a low value to a high value.

Method:
To meet the objective, the first thing required is to find an appropriate circuit model. The
saturable core transformer is represented by its nonlinear dynamic model. With the help of that
model, a Simulink block diagram has been developed in MATLAB. The Simulink model is examined
under various circuit conditions and the stability of the system is analyzed at different stages.

Results:
It has been found that the system passes through a series of period-doubling bifurcation and
ultimately reaches chaos.

Conclusion:
The model and the method used in this paper can be used as a very helpful tool as well
as a powerful technique to understand the effect of specific parameters in the final behavior of the
ferroresonance phenomenon.
Por Uma Imaginação Etnográfica Na Educação
Authors: Golbspan Ricardo , Gandin Luís Armando 
Published: August 2022

Este artigo tem como objetivo apresentar a proposta de imaginação etnográfica como uma ferramenta potente para a pesquisa crítica em educação. A partir de revisão de literatura, o texto propõe que há uma rica diversidade de práticas etnográficas em educação, apesar do relativo ceticismo frente a este desenvolvimento. Através deste estudo bibliográfico, se apontou para a possibilidade de abordar a realidade educacional brasileira sob a perspectiva da imaginação etnográfica, de acordo com Paul Willis. O manuscrito, assim, propõe uma discussão teórica sobre esta categoria, estabelece uma proposta de confiabilidade metodológica para a operação da imaginação etnográfica e sugere um passo a passo para sua efetivação. Como resultados, se destacam uma proposta de nova sensibilidade frente ao trabalho etnográfico na educação, um convite à operação rigorosa da perspectiva metodológica e uma reorientação de procedimentos metodológicas de coleta e análise de dados etnográficos.
Characteristics of Smart Health Ecosystems That Support Self-care Among People With Heart Failure: Scoping Review
Authors: Nourse Rebecca , Lobo Elton , McVicar Jenna , Kensing Finn , Islam Sheikh Mohammed Shariful , Kayser Lars , Maddison Ralph 
Published: August 2022

Background
The management of heart failure is complex. Innovative solutions are required to support health care providers and people with heart failure with decision-making and self-care behaviors. In recent years, more sophisticated technologies have enabled new health care models, such as smart health ecosystems. Smart health ecosystems use data collection, intelligent data processing, and communication to support the diagnosis, management, and primary and secondary prevention of chronic conditions. Currently, there is little information on the characteristics of smart health ecosystems for people with heart failure.

Objective
We aimed to identify and describe the characteristics of smart health ecosystems that support heart failure self-care.

Methods
We conducted a scoping review using the Joanna Briggs Institute methodology. The MEDLINE, Embase, CINAHL, PsycINFO, IEEE Xplore, and ACM Digital Library databases were searched from January 2008 to September 2021. The search strategy focused on identifying articles describing smart health ecosystems that support heart failure self-care. A total of 2 reviewers screened the articles and extracted relevant data from the included full texts.

Results
After removing duplicates, 1543 articles were screened, and 34 articles representing 13 interventions were included in this review. To support self-care, the interventions used sensors and questionnaires to collect data and used tailoring methods to provide personalized support. The interventions used a total of 34 behavior change techniques, which were facilitated by a combination of 8 features for people with heart failure: automated feedback, monitoring (integrated and manual input), presentation of data, education, reminders, communication with a health care provider, and psychological support. Furthermore, features to support health care providers included data presentation, alarms, alerts, communication tools, remote care plan modification, and health record integration.

Conclusions
This scoping review identified that there are few reports of smart health ecosystems that support heart failure self-care, and those that have been reported do not provide comprehensive support across all domains of self-care. This review describes the technical and behavioral components of the identified interventions, providing information that can be used as a starting point for designing and testing future smart health ecosystems.
Developing an Immersive Virtual Reality Training System for Novel Pediatric Power Wheelchair Users: Protocol for a Feasibility Study
Authors: Drisdelle Sara , Power Liam , Thieu Scott , Sheriko Jordan 
Published: August 2022

Background
Power wheelchairs can empower children with physical limitations to gain independence in their everyday lives; however, traditional methods of power wheelchair training are often limited by poor accessibility and safety concerns. Immersive virtual reality technology (IVRT) uses advanced display technology to place users in a fully immersive web-based environment that can support real-time skills training, often requiring less resources and fewer safety concerns than real-world methods. IVRT interventions have shown to be a feasible training option among adult power wheelchair users; however, there is still a need to understand the technical and clinical feasibility of developing an IVRT power wheelchair training tool for the pediatric population.

Objective
This proposed study aims to use expert feedback and an iterative design process to develop an IVRT training intervention for pediatric power wheelchair skill development.

Methods
This 3-phase feasibility study will be conducted within the assistive technology unit of a public pediatric hospital. Separate participant groups will be recruited for each phase, consisting of approximately 10 to 15 clinicians (phase 1), 10 pediatric power wheelchair users (phase 2), and 15 to 20 additional pediatric power wheelchair users (phase 3). Phase 1 will be conducted to gather feedback on the baseline IVRT training intervention. Clinicians will test the intervention and assess its usability and acceptability using qualitative and quantitative methods. Phase 1 participants will also be invited back for a subsequent session to reassess a revised version of the training intervention that has been updated based on their previous feedback. Phase 2 and phase 3 will also use mixed methods to gather feedback on the usability, acceptability, and user experience of the IVRT training intervention from current pediatric power wheelchair users. In addition, phase 3 participants will perform a skills transfer assessment to compare power mobility skill performance between the virtual reality and real-life environments. Data gathered in phase 2 will be used to further refine the IVRT intervention, whereas phase 3 data will be used to statistically evaluate the final version.

Results
This study was approved by the Izaak Walton Killam Health Centre research ethics board in August 2021. Phase 1 testing began in February 2022. The entire study is expected to be completed by 2023.

Conclusions
The results of this study will be used to create an IVRT training intervention for pediatric power wheelchair skill development through an iterative and collaborative design process. Results may also assist in directing future studies in this area.

International Registered Report Identifier (IRRID)
DERR1-10.2196/39140
Digital Interventions for Psychological Well-being in University Students: Systematic Review and Meta-analysis
Authors: Ferrari Madeleine , Allan Stephanie , Arnold Chelsea , Eleftheriadis Dina , Alvarez-Jimenez Mario , Gumley Andrew , Gleeson John F 
Published: August 2022

BackgroundLife at university provides important opportunities for personal growth; however, this developmental phase also coincides with the peak period of risk for the onset of mental health disorders. In addition, specific university lifestyle factors, including impaired sleep and academic and financial stress, are known to exacerbate psychological distress in students. As a result, university students have been identified as a vulnerable population who often experience significant barriers to accessing psychological treatment. Digital psychological interventions are emerging as a promising solution for this population, but their effectiveness remains unclear.ObjectiveThis systematic review and meta-analysis aimed to assess digital interventions targeting psychological well-being among university students.MethodsDatabase searches were conducted on December 2, 2021, via Embase, MEDLINE, PsycINFO, and Web of Science.ResultsA total of 13 eligible studies were identified, 10 (77%) of which were included in the meta-analysis. Mean pre-post effect sizes indicated that such interventions led to small and significant improvement in psychological well-being (Hedges g=0.32, 95% CI 0.23-0.4; P<.001). These effects remained, albeit smaller, when studies that included a wait-list control group were excluded (Hedges g=0.22, 95% CI 0.08-0.35; P=.002). An analysis of acceptance and commitment therapy approaches revealed small and significant effects (k=6; Hedges g=0.35, 95% CI 0.25-0.45; P<.001).ConclusionsDigital psychological interventions hold considerable promise for university students, although features that optimize service delivery and outcomes require further assessment.Trial RegistrationPROSPERO CRD42020196654; https:/www.crd.york.ac.uk/prospero/display_record.php?RecordID=196654