bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH LAMA KERJA TERHADAP KADAR HEMOGLOBIN PADA PEKERJA YANG TERPAPAR ASAP KENDARAHAN BERMOTOR
Authors: INDWEK DEIIIN D 
Published: July 2022

Kendaraan bermotor merupakan penyebab utama polusi udarah di perkotaan.Hal ini menyebabakan para pekerja memiliki resiko tinggi terpapar karbon monoksida (CO), nitrogen oksida (NOx), hidrokarbon (HC), Sulfur dioksida (SO2), timbal (Pb) dan karbon dioksida (CO) yang terdapat pada asap kendaraan bermotor. Zat toksin tersebut dapat mempengaruhi kadar Hb sebab Kadar Hb berfungsi mengantar oksigen ke seluruh tubuh dimana Zat yang terdapat pada asap kendaraan bermotor terhirup masuk melaluhi nasal passages, pharynx, lariynx, trachea, bronchi, bronchioles, alveoli. di alveoli terjadi pertukaran gas dengan darah untuk berikatan dengan Hb kemudian didistribusikan ke seluruh tubuh. Penelitian ini bertujuan untuk mengetauhi pengaruh lama kerja terhadap kadar Hb pada pekerja yang terpapar asap kendaraan bermotor. Penelitian ini menggunakan desain Studi literature dengan disintesis menggunakan metode naratif. Kriteria artikel/jurnal yang digunakan adalah yang diterbitkan tahun 2015-2020 dan artikel/jurnal ini dikumpulkan dengan menggunakan mesin pencari seperti Scient Direct, e-resorces, proquest dan Scholar.Hasil penelitian ini menunjukan bahwa zat yang terdapat pada asap kendaraan bermotor memiliki pengaruh terhadap kadar Hb dan semakin lama terpapar degan lama kerja 3 tahun dengan masa kerja 3-9 jam/hari beresiko tinggi mengalami penuruna kadar Hb hasil penelitian menurut 16 jurnal yang telah direview. Diharapkan penggunaan APD (Masker) bagai pekerja yang beresiko terpapar asap kendaraan bermotor dalam waktu lama.
PENGARUH APLIKASI BERBASIS ANDROID AYO DEDIS UNTUK PENINGKATAN PENGETAHUAN GIZI SEIMBANG TERHADAP STUNTING PADA IBU HAMIL
Authors: SEKARWATI LENA 
Published: July 2022

Abstrak
Sekarwati, Lena. 2021. The Effect of Android-Based Ayo Dedis Application on Increasing Knowledge of Balanced Nutrition on Stunting in Pregnant Women During a Pandemic in the Work Area of Karangploso Health Center, Malang Regency. Thesis. Nursing Study Program of Widyagama Husada School of Health. Advisors: (1) Frengki Apryanto, S.Kep., Ners., M.Kep. (2) Rosly Zunaedi, S.Kep., Ners., M.Kep.

Background: Stunting may occur in mother who are too young, too old, having many birth record and short birth interval. Today is an era where everyone uses social media to interact and find information. Therefore researchers are interested in conducting research using android-based applications for prevention and early detection of pregnant women in order to reduce stunting rates and get enough information with gadgets.

Objective: to examine the effect of the Android-based Ayo Dedis application on pregnant women.

Methods: The effect of pregnant women's knowledge about stunting before and after using the "Ayo Dedis" application was tested using the Paired T-Test which is a parametric test that can be used on two paired data. The purpose of this test is to see whether there is a difference in the mean between two paired or related samples, whether there is a significant relationship or difference in the study used with ordinal data.

Results: Based on data analysis, the paired sample test is an output table that shows the results of the tests carried out. This can be seen from the significance value (2-tailed) of 0.004 (p<0.05). So that the results of the pretest and posttest experienced a significant change. Based on descriptive statistics, pretest and posttest proved to be higher than posttest.

Conclusion: It can be concluded that there is effect of the android-based Ayo Dedis application on increasing knowledge of balanced nutrition in pregnant women before and after giving the application with results (p <0.05).

Literature : 32 References (2010-2021)
Keywords: Stunting, Application, Pregnant Women
HUBUNGAN ANTARA KEPATUHAN TERAPI HEMODIALISIS DENGAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK
Authors: AGUS TIAR MOHAMAD 
Published: July 2022

ABSTRACT
Hemodialysis undertaken by patients can maintain survival while changing the patient's lifestyle. Adherence in hemodialysis is very necessary to maintain life. The purpose of this study was to determine the correlation between adherence to hemodialysis and quality of life in hemodialysis patients at Dr. Saiful Anwar Malang. This research is a descriptive analytic correlative research design with a cross sectional method approach. The sample in this study were 37 CKD patients who underwent hemodialysis in the Malahayati Hemodialysis Room, RSUD Dr. Saiful Anwar Malang. There is a relationship between the level of compliance and the level of quality of life of chronic kidney failure patients undergoing hemodialysis in the Hemodialysis Room of RSUD Dr. Saiful Anwar Malang (p value= 0.005). The relationship is positive by 0,451, the more positive the patient's compliance, the higher the quality of life of chronic kidney failure patients undergoing hemodialysis in the Hemodialysis Room of RSUD Dr. Saiful Anwar Malang.

Keywords : Chronic Kidney Failure, Hemodialysis, Adherence, Quality of Life
HUBUNGAN ANTARA PEMANTAUAN INTAKE OUTPUT CAIRAN PENDERITA CKD DENGAN TERJADINYA OVERLOAD CAIRAN
Authors: DEWI AJENG RUVITA 
Published: July 2022

Abstract
Monitoring fluid intake and output in patients with CKD is the main action to reduce the occurrence of fluid overload in patients with CKD. Fluid overload can cause shortness of breath, edema, and acites. Lack of attention to fluid intake and output will lead to more serious health problems. This study aims to determine the relationship between monitoring of CKD fluid intake output and the occurrence of fluid overload at RSU Karsa Husada Batu. The research design used was Correlative Study. Retrieval of data using Cross Sectional. The sampling method used was Purposive Sampling. The sample in this study amounted to 22 people. The intake output monitoring variable was assessed using the fluid intake output chart questionnaire, while the fluid overload variable was the head to toe observation sheet. The result of the Spearman Rank Correlation test shows a p value of 0.001 where the p value is smaller than alpha 0.05 (p value (0.001) <alpha (0.05), which means that there is a significant relationship between monitoring the fluid output intake of patients with CKD and the occurrence of fluid overload in RSU Karsa Husada Batu. The correlation coefficient of 0.661 is a number that is positive. So the relationship between Monitoring Intake of Fluid Output for CKD Patients with the Occurrence of Fluid Overload is unidirectional, thus it means that the better monitoring of fluid output intake for CKD sufferers, the risk of overload Also decreasing The effectiveness of limiting the amount of fluids in CRF patients depends on the patient's knowledge of the amount of fluids that can be drunk and efforts to create restrictions on fluid intake through monitoring the intake of fluid output per day . This is very necessary to be applied consistently in patients with CKD.
Keyword : monitoring of fluid intake, output, overload.
Lenalidomide potentially reduced the level of cell- associated HIV RNA and improved persistent inflammation in patients with HIV-associated cryptococcal meningitis a pilot study
Authors: Liu Xiang , Zhu Xueling , Peng Xiaorong , Tao Ran , Wan Zhikai , Hui Jiangjin , Guo Yongzheng , Hang Ying , Zhu Biao 
Published: July 2022

BackgroundThe HIV-1 reservoir is a major barrier to curative strategies. Inflammation is an important factor for HIV-1 reservoir persistence. Lenalidomide regulates inflammatory cytokines efficiently. We examined whether lenalidomide could inhibit HIV-1 transcription and reduce systemic inflammation in people living with HIV.MethodsLenalidomide was administered orally for 48 weeks to patients with HIV-associated cryptococcal meningitis (HIV-CM). A HIV-1 latency model was treated with or without lenalidomide ex vivo for 5 days. The primary endpoints were change in HIV reservoir markers and inflammatory cytokines in both the cohort and cell model.ResultsThirteen participants were enrolled from May 2019 to September 2020. The median change in cell-associated (CA) HIV RNA between baseline and 48 weeks was 0.81 log10 copies/million peripheral blood mononuclear cells (PBMCs). The CA HIV RNA decreased significantly in the cohort (P = 0.021). Serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) gradually diminished with lenalidomide treatment until 48 weeks (P = 0.007, P = 0.014, respectively). C-reactive protein/IL-6/TNF-α and CA HIV RNA were significantly correlated (P = 0.0027, 0.0496, and 0.0346, respectively). Lenalidomide also significantly decreased HIV core P24 (P = 0.0038) and CA HIV RNA in CD8-depleted PBMCs (P = 0.0178) ex vivo. TNF-α and IL-6 were significantly reduced in the CD8-depleted PBMC supernatant (P = 0.004, P &lt; 0.0001, respectively) while IL-10 levels increased significantly on lenalidomide compared to no-lenalidomide treatment (P &lt; 0.0001).ConclusionsLenalidomide was preliminarily confirmed to reduce the level of cell- associated HIV RNA and improve persistent inflammation in patients with HIV-Associated cryptococcal meningitis, which was a potential intervention for clinical use to inhibit viral transcription of the HIV-1 reservoir and reduced HIV-related inflammation in HIV-1 patients during ART.
Ectopic fat is associated with cardiac remodeling—A comprehensive assessment of regional fat depots in type 2 diabetes using multi-parametric MRI
Authors: Edin Carl , Ekstedt Mattias , Scheffel Tobias , Karlsson Markus , Swahn Eva , Östgren Carl Johan , Engvall Jan , Ebbers Tino , Leinhard Olof Dahlqvist , Lundberg Peter , Carlhäll Carl-Johan 
Published: July 2022

BackgroundDifferent regional depots of fat have distinct metabolic properties and may relate differently to adverse cardiac remodeling. We sought to quantify regional depots of body fat and to investigate their relationship to cardiac structure and function in Type 2 Diabetes (T2D) and controls.MethodsFrom the SCAPIS cohort in Linköping, Sweden, we recruited 92 subjects (35% female, mean age 59.5 ± 4.6 years): 46 with T2D and 46 matched controls. In addition to the core SCAPIS data collection, participants underwent a comprehensive magnetic resonance imaging examination at 1.5 T for assessment of left ventricular (LV) structure and function (end-diastolic volume, mass, concentricity, ejection fraction), as well as regional body composition (liver proton density fat fraction, visceral adipose tissue, abdominal subcutaneous adipose tissue, thigh muscle fat infiltration, fat tissue-free thigh muscle volume and epicardial adipose tissue).ResultsCompared to the control group, the T2D group had increased: visceral adipose tissue volume index (P &lt; 0.001), liver fat percentage (P &lt; 0.001), thigh muscle fat infiltration percentage (P = 0.02), LV concentricity (P &lt; 0.001) and LV E/e'-ratio (P &lt; 0.001). In a multiple linear regression analysis, a negative association between liver fat percentage and LV mass (St Beta −0.23, P &lt; 0.05) as well as LV end-diastolic volume (St Beta −0.27, P &lt; 0.05) was found. Epicardial adipose tissue volume and abdominal subcutaneous adipose tissue volume index were the only parameters of fat associated with LV diastolic dysfunction (E/e'-ratio) (St Beta 0.24, P &lt; 0.05; St Beta 0.34, P &lt; 0.01, respectively). In a multivariate logistic regression analysis, only visceral adipose tissue volume index was significantly associated with T2D, with an odds ratio for T2D of 3.01 (95% CI 1.28–7.05, P &lt; 0.05) per L/m2 increase in visceral adipose tissue volume.ConclusionsEctopic fat is predominantly associated with cardiac remodeling, independently of type 2 diabetes. Intriguingly, liver fat appears to be related to LV structure independently of VAT, while epicardial fat is linked to impaired LV diastolic function. Visceral fat is associated with T2D independently of liver fat and abdominal subcutaneous adipose tissue.
Detection of left ventricular wall motion abnormalities from volume rendering of 4DCT cardiac angiograms using deep learning
Authors: Chen Zhennong , Contijoch Francisco , Colvert Gabrielle M. , Manohar Ashish , Kahn Andrew M. , Narayan Hari K. , McVeigh Elliot 
Published: July 2022

BackgroundThe presence of left ventricular (LV) wall motion abnormalities (WMA) is an independent indicator of adverse cardiovascular events in patients with cardiovascular diseases. We develop and evaluate the ability to detect cardiac wall motion abnormalities (WMA) from dynamic volume renderings (VR) of clinical 4D computed tomography (CT) angiograms using a deep learning (DL) framework.MethodsThree hundred forty-three ECG-gated cardiac 4DCT studies (age: 61 ± 15, 60.1% male) were retrospectively evaluated. Volume-rendering videos of the LV blood pool were generated from 6 different perspectives (i.e., six views corresponding to every 60-degree rotation around the LV long axis); resulting in 2058 unique videos. Ground-truth WMA classification for each video was performed by evaluating the extent of impaired regional shortening visible (measured in the original 4DCT data). DL classification of each video for the presence of WMA was performed by first extracting image features frame-by-frame using a pre-trained Inception network and then evaluating the set of features using a long short-term memory network. Data were split into 60% for 5-fold cross-validation and 40% for testing.ResultsVolume rendering videos represent ~800-fold data compression of the 4DCT volumes. Per-video DL classification performance was high for both cross-validation (accuracy = 93.1%, sensitivity = 90.0% and specificity = 95.1%, κ: 0.86) and testing (90.9, 90.2, and 91.4% respectively, κ: 0.81). Per-study performance was also high (cross-validation: 93.7, 93.5, 93.8%, κ: 0.87; testing: 93.5, 91.9, 94.7%, κ: 0.87). By re-binning per-video results into the 6 regional views of the LV we showed DL was accurate (mean accuracy = 93.1 and 90.9% for cross-validation and testing cohort, respectively) for every region. DL classification strongly agreed (accuracy = 91.0%, κ: 0.81) with expert visual assessment.ConclusionsDynamic volume rendering of the LV blood pool combined with DL classification can accurately detect regional WMA from cardiac CT.
Analysis of the miRNA expression from the adipose tissue surrounding the adrenal neoplasia
Authors: Concistrè Antonio , Petramala Luigi , Circosta Francesco , Romagnoli Priscilla , Soldini Maurizio , Bucci Marco , De Cesare Domenico , Cavallaro Giuseppe , De Toma Giorgio , Cipollone Francesco , Letizia Claudio 
Published: July 2022

BackgroundPrimary aldosteronism (PA) is characterized by several metabolic changes such as insulin resistance, metabolic syndrome, and adipose tissue (AT) inflammation. Mi(cro)RNAs (miRNAs) are a class of non-coding small RNA molecules known to be critical regulators in several cellular processes associated with AT dysfunction. The aim of this study was to evaluate the expression of some miRNAs in visceral and subcutaneous AT in patients undergoing adrenalectomy for aldosterone-secreting adrenal adenoma (APA) compared to the samples of AT obtained in patients undergoing adrenalectomy for non-functioning adrenal mass (NFA).MethodsThe quantitative expression of selected miRNA using real-time PCR was analyzed in surrounding adrenal neoplasia, peri-renal, and subcutaneous AT samples of 16 patients with adrenalectomy (11 patients with APA and 5 patients with NFA).ResultsReal-time PCR cycles for miRNA-132, miRNA-143, and miRNA-221 in fat surrounding adrenal neoplasia and in peri-adrenal AT were significantly higher in APA than in patients with NFA. Unlike patients with NFA, miRNA-132, miRNA-143, miRNA-221, and miRNA-26b were less expressed in surrounding adrenal neoplasia AT compared to subcutaneous AT in patients with APA.ConclusionThis study, conducted on tissue expression of miRNAs, highlights the possible pathophysiological role of some miRNAs in determining the metabolic alterations in patients with PA.
Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population
Authors: Ji Wenjun , Gao Lan , Sun Pengfei , Jia Jia , Li Jianping , Wang Xingang , Fan Fangfang , Zhang Yan 
Published: July 2022

ObjectiveWe aimed to explore the association between the triglyceride-glucose (TyG) index, a marker of insulin resistance (IR), and vascular target organ damage (TOD) in a Beijing community-based population, China.MethodsA total of 6,015 participants from an atherosclerosis cohort survey performed in the Shijingshan District in Beijing, China were included in our analysis. Vascular TOD, such as carotid-femoral pulse wave velocity (cfPWV), brachial-ankle pulse wave velocity (baPWV), and the urine albumin-to-creatinine ratio (UACR) were all evaluated.ResultsThe overall mean age of all the participants was 62.35 years, 3,951 (65.69%) were female, and mean TyG index was 8.81. In univariable regression analyzes, an increased TyG index was associated with higher cfPWV, baPWV, lnUACR, and higher risk of cfPWV ≥ 10 m/s, baPWV ≥ 1,800 cm/s, and UACR ≥ 30 mg/g, respectively. Multivariable regression analyzes showed subjects with the TyG index in top tertile had a significant increase in cfPWV (β = 0.29 m/s; 95% confidence interval [95% CI] 0.19–0.40; pfortrend &lt; 0.001), baPWV (β = 69.28 cm/s; 95% CI 50.97–87.59; pfortrend &lt; 0.001), lnUACR (β = 0.23; 95% CI 0.13–0.34; pfortrend &lt; 0.001), and had a higher risk of cfPWV ≥ 10 m/s (odds ratio [OR] = 1.47; 95% CI 1.17–1.85; pfortrend &lt; 0.001), baPWV ≥ 1,800 cm/s (OR = 1.79; 95% CI 1.48–2.17; pfortrend &lt; 0.001), and UACR ≥ 30 mg/g (OR = 1.71; 95% CI 1.30–2.24; pfortrend &lt; 0.001) after fully adjusting for age, sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), self-reported coronary heart disease (CHD) and stroke, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs. Consistent conclusions were obtained in the subgroups without hypoglycemic and lipid-lowering medications or aged younger than 65 years old.ConclusionsThe TyG index was positively associated with artery stiffness and nephric microvascular damage in a Beijing community-based population in China. This result provides evidence that the TyG index may serve as a simple and effective indicator to reflect vascular TOD.
Determinants of improvement of left ventricular mechano-energetic efficiency in hypertensive patients
Authors: Lembo Maria , Trimarco Valentina , Manzi Maria Virginia , Mancusi Costantino , Esposito Giovanni , Esposito Salvatore , Morisco Carmine , Izzo Raffaele , Trimarco Bruno 
Published: July 2022

BackgroundArterial hypertension, especially when coexisting with other cardiovascular risk factors, could determine an imbalance between myocardial energetic demand and altered efficiency, leading to an early left ventricular (LV) systolic dysfunction, even in terms of echo-derived mechano-energetic efficiency indexed for myocardial mass (MEEi). We aim to analyse an improvement in LV MEEi, if any, in a population of hypertensive patients with a long-term follow-up and to identify clinical, metabolic and therapeutic determinants of LV MEEi amelioration.Materials and methodsIn total, 7,052 hypertensive patients, followed-up for 5.3 ± 4.5 years, enrolled in the Campania Salute Network, underwent echocardiographic and clinical evaluation. LV MEEi was obtained as the ratio between stroke volume and heart rate and normalized per grams of LV mass and ΔMEEi was calculated as difference between follow-up and baseline MEEi. Patients in the highest ΔMEEi quartile (≥0.0454 mL/s/g) (group 1) were compared to the merged first, second and third quartiles (&lt;0.0454 mL/s/g) (group 2). METS-IR (Metabolic Score for Insulin Resistance), an established index of insulin sensitivity, was also derived.ResultsPatients with MEEi improvement experienced a lower rate of major cardiovascular events (p = 0.02). After excluding patients experiencing cardiovascular events, patients in group 1 were younger (p &lt; 0.0001), less often diabetic (p = 0.001) and obese (p = 0.035). Group 1 experienced more frequently LV mass index reduction, lower occurrence of LV ejection fraction reduction, and had a better metabolic control in terms of mean METS-IR during the follow-up (all p &lt; 0.0001). Beta-blockers were more often used in group 1 (p &lt; 0.0001) than group 2. A logistic regression analysis showed that younger age, lower mean METS-IR values, more frequent LV mass index reduction and therapy with beta-blockers were significantly associated with LV MEEi improvement, independently of presence of diabetes and obesity.ConclusionMetabolic control and therapy with beta-blockers could act in a synergic way, determining an improvement in LV MEEi in hypertensive patients over time, possibly confining cardiac damage and hampering progression toward heart failure.
User perceptions about sharing exposure notification information for communicable diseases
Authors: Schooley Benjamin , Feldman Sue S. 
Published: July 2022

BackgroundThe (GuideSafe™) Exposure Notification System (ENS) was built and deployed in (Alabama) for anonymous sending and receiving of COVID-19 exposure alerts to people who have been in close contact with someone who later reports a positive COVID-19 test. Little is known about how the demographic groups perceive recent privacy-preserving the ENS innovations, including their usability, usefulness, satisfaction, and continued interest in sharing COVID-19 exposure information. The purpose of this study was to investigate how users across the demographic groups perceive the sharing of exposure information with various types of organizations and to investigate how end-user perceptions of the ENS usability, usefulness, and satisfaction differ across the demographic groups within the context of a statewide deployment of an exposure notification system.MethodsA survey was administered to (state residents blinded for review) (N = 1,049) to assess propensity to share COVID-19 infection data and evaluate end-user perceptions about usability, usefulness, and satisfaction with the (Alabama) ENS. The ANOVA and the Tukey's Honestly Significant Difference (HSD) post-hoc tests were conducted to assess the demographic group differences.ResultsThe ENS survey participants had a high awareness of contact tracing, exposure notifications, and the (GuideSafe™) ENS and reported having downloaded the app. Survey results revealed the majority of participants rated the app as useful (n = 490, 79%), easy to use (n = 490, 79%), and reported satisfaction with its use (n = 546, 88%). Other results suggest that ethnicity and age may be important factors for trust in sharing exposure information.ConclusionThe (GuideSafe™) system was one integrated component of comprehensive education and work re-entry strategy across (Alabama) that reached a broad user base. Users across the different demographic groups perceive the sharing of information about their communicable disease exposures differently. Furthermore, demographic factors play a role in which types of organizations individuals are willing to share their communicable disease exposure information. Public health institutions, employers, schools, healthcare providers, and technology designers may want to consider these findings as they construct technologies and perform outreach campaigns aimed at reducing infection rates with the ENS and related technologies.