bluuebunny/crossref_metadata_2025_split huggingface dataset:
An empirical and CFD analysis of combustion performance of a diesel engine fueled with tomato seed oil biodiesel
Authors: Karami Rahim , Rasul M. G. , Khan M. M. K 
Published: September 2022

Abstract
Tomato seed oil biodiesel (TSOB) could be considered as a second generation and clean-burning renewable substitute for petroleum diesel. It is about 72% by weight of tomato waste, which contains an average of 24% oil. This paper investigated the effects of four different Diesel-TSOB blends on the combustion performance of an indirect injection (IDI) diesel engine. In-cylinder pressure (CP) and combustion parameters at five different engine loads and seven speeds were experimentally measured. Then for 2D CFD simulation of the emissions and combustion processes, AVL FIRE software was used and the results evaluated with experimental data. The purpose of the study was to determine the combustion process and its effects on the performance and emissions of the engine. The outcomes for B10 at 100% load addressed that, the peak CP of about 67 MPa was found at 1200 rpm which occurred at 13° ATDC, while at 2200 rpm the peak CP was 69 MPa and occurred at 1° ATDC, and at 2400 rpm the peak CP was found to be about 66 MPa which occurred approximately at TDC. The simulated results found that the peak in-cylinder temperature of 1600° K corresponds to the 10% TSOB blend (B10) and the longest mixing-controlled period occurs for B10 at 27° CA. The simulation also showed that B5 had the longest jet penetration of about 44 mm (at about 100° CA) in comparison to 43 mm for B20, 41 mm for B10 and 39.8 mm for B0 (pure diesel) which occurred at less than 100° CA. The longest jet penetration duration of was found to be about 44 mm for B5 at about100° CA. The results showed that B10 has the biggest accumulative heat release (approximately 1900 J) and highest fuel energy efficiency. The 2-D CFD simulation revealed that the unburnt equivalence ratio in the main combustion chamber is lesser than in the spherical combustion chamber.
Intravenous ferric derisomaltose in iron-deficient patients undergoing transcatheter aortic valve implantation due to severe aortic stenosis: study protocol of the randomised controlled IIISAS trial
Authors: Bardan Sara , Kvaslerud Anette Borger , Andresen Kristoffer , Kløve Sophie Foss , Edvardsen Thor , Gullestad Lars , Broch Kaspar 
Published: September 2022

IntroductionIron deficiency is a prevalent comorbidity in patients with severe aortic stenosis and may be associated with procedural and clinical outcomes after transcatheter aortic valve implantation (TAVI). In the Intravenous Iron Supplement for Iron Deficiency in Patients with Severe Aortic Stenosis (IIISAS) trial, we aim to examine whether a single administration of ferric derisomaltose can improve physical capacity after TAVI.Methods and analysisThis randomised, double-blind, placebo-controlled trial aims to enrol 150 patients with iron deficiency who are scheduled for TAVI due to severe aortic stenosis. The study drug and matching placebo are administered approximately 3 months prior to TAVI, and the patients are followed for 3 months after TAVI. Inclusion criteria are iron deficiency, defined as serum ferritin<100 µg/L or ferritin between 100 and 300 µg/L in combination with a transferrin saturation<20% and written informed consent. Exclusion criteria include haemoglobin<10 g/dL, red blood cell disorders, end-stage kidney failure, intolerance to ferric derisomaltose, and ongoing infections. The primary endpoint is the baseline-adjusted distance walked on a 6 min walk test (6MWT) 3 months after TAVI. Secondary end points include quality of life, New York Heart Association functional class (NYHA functional class), and skeletal muscle strength.Ethics and disseminationEthical approval was obtained from the Regional Committee for Medical and Health Research of South-Eastern Norway and The Norwegian Medicines Agency. Enrolment has begun, and results are expected in 2022. The results of the IIISAS trial will be disseminated by presentations at international and national conferences and by publications in peer-reviewed journals.Trial registration numberNCT04206228
Intraurban socioeconomic inequalities in life expectancy: a population-based cross-sectional analysis in the city of Córdoba, Argentina (2015–2018)
Authors: Rodríguez López Santiago , Tumas Natalia , Bilal Usama , Moore Kari A , Acharya Binod , Quick Harrison , Quistberg D Alex , Acevedo Gabriel E , Diez Roux Ana V 
Published: September 2022

ObjectivesTo evaluate variability in life expectancy at birth in small areas, describe the spatial pattern of life expectancy, and examine associations between small-area socioeconomic characteristics and life expectancy in a mid-sized city of a middle-income country.DesignCross-sectional, using data from death registries (2015–2018) and socioeconomic characteristics data from the 2010 national population census.Participants/setting40 898 death records in 99 small areas of the city of Córdoba, Argentina. We summarised variability in life expectancy at birth by using the difference between the 90th and 10th percentile of the distribution of life expectancy across small areas (P90-P10 gap) and evaluated associations with small-area socioeconomic characteristics by calculating a Slope Index of Inequality in linear regression.Primary outcomeLife expectancy at birth.ResultsThe median life expectancy at birth was 80.3 years in women (P90-P10 gap=3.2 years) and 75.1 years in men (P90-P10 gap=4.6 years). We found higher life expectancies in the core and northwest parts of the city, especially among women. We found positive associations between life expectancy and better small-area socioeconomic characteristics, especially among men. Mean differences in life expectancy between the highest versus the lowest decile of area characteristics in men (women) were 3.03 (2.58), 3.52 (2.56) and 2.97 (2.31) years for % adults with high school education or above, % persons aged 15–17 attending school, and % households with water inside the dwelling, respectively. Lower values of % overcrowded households and unemployment rate were associated with longer life expectancy: mean differences comparing the lowest versus the highest decile were 3.03 and 2.73 in men and 2.57 and 2.34 years in women, respectively.ConclusionLife expectancy is substantially heterogeneous and patterned by socioeconomic characteristics in a mid-sized city of a middle-income country, suggesting that small-area inequities in life expectancy are not limited to large cities or high-income countries.
Satisfaction and its determinants of rural upper gastrointestinal cancer screening in China: a preliminary cross-sectional study
Authors: Feng Xiang , Zhu Jin-Hua , Hua Zhao-Lai , Xu Xing , Li Yanyan , Li Jun , Song Guo-Hui , Wang Xingzheng , Su Ming , Zhou Jin-Yi 
Published: September 2022

ObjectivesTo assess participants’ satisfaction with and predictors of upper gastrointestinal cancer screening in rural areas.DesignCross-sectional study.SettingTen screening centres in seven cities across five provinces in China.ParticipantsOf the 452 participants screened during the survey period, 438 completed the survey (response rate: 96.90%).Primary outcome measuresScreening satisfaction was the primary outcome and it was assessed using the Patient Satisfaction Questionnaire-18. Ordinal logistic regression analysis was used to analyse the predictors of satisfaction.ResultsThe percentages of satisfaction with the General Satisfaction, Technical Quality, Interpersonal Manner, Communication, Financial Aspects, Time Spent With Doctor, and Convenience and Accessibility dimensions were 95.89%, 79.68%, 88.36%, 83.56%, 75.11%, 82.19% and 66.44%, respectively. Education (OR 0.25, 95% CI 0.07 to 0.90), health self-assessment (OR 15.29, 95% CI 2.86 to 81.78) and family history of cancer (OR 4.20, 95% CI 1.29 to 13.71) were associated with General Satisfaction. Residence (OR 4.31, 95% CI 1.89 to 9.81) was associated with Technical Quality. Occupation (OR 0.27, 95% CI 0.08 to 0.88), health self-assessment (OR 11.30, 95% CI 3.94 to 32.43), screening purpose (OR 0.18, 95% CI 0.03 to 0.92) and distance from the screening centre (OR 4.59, 95% CI 1.35 to 15.61) were associated with interpersonal manner. Gender (OR 1.85, 95% CI 1.02 to 3.34), residence (OR 3.23, 95% CI 1.23 to 8.53) and endoscopy in the previous year (OR 2.79, 95% CI 1.13 to 6.90) were associated with Communication. Body mass index (BMI; OR 5.06, 95% CI 1.40 to 18.25) and health self-assessment (OR 2.09, 95% CI 1.12 to 3.88) were associated with financial aspects. Gender (OR 1.90, 95% CI 1.07 to 3.38), residence (OR 3.19, 95% CI 1.30 to 7.79), BMI (OR 5.26, 95% CI 1.14 to 24.34) and health self-assessment (OR 2.14, 95% CI 1.06 to 4.34) were associated with time spent with doctor. Gender (OR 1.64, 95% CI 1.04 to 2.60) and residence (OR 3.17, 95% CI 1.46 to 6.88) were associated with convenience and accessibility.ConclusionThere was heterogeneity across the dimensions of satisfaction with rural upper gastrointestinal cancer screening. Project manager should prioritise improving the aspects related to the convenience and accessibility dimension. Furthermore, to improve the efficiency of potential interventions, the predictors of the various dimensions should be considered.
Running on empty: a longitudinal global study of psychological well-being among runners during the COVID-19 pandemic
Authors: Vistisen Helene Tilma , Sønderskov Kim Mannemar , Dinesen Peter Thisted , Brund René Børge Korsgaard , Nielsen Rasmus Østergaard , Østergaard Søren Dinesen 
Published: September 2022

ObjectivesThere are indications that the COVID-19 pandemic has had a profound negative effect on psychological well-being. Here, we investigated this hypothesis using longitudinal data from a large global cohort of runners, providing unprecedented leverage for understanding how the temporal development in the pandemic pressure relates to well-being across countries.DesignProspective cohort study.SettingGlobal.ParticipantsWe used data from the worldwide Garmin-RUNSAFE cohort that recruited runners with a Garmin Connect account, which is used for storing running activities tracked by a Garmin device. A total of 7808 Garmin Connect users from 86 countries participated.Primary and secondary outcome measuresFrom 1 August 2019 (prepandemic) to 31 December 2020, participants completed surveys every second week that included the five-item WHO Well-Being Index (WHO-5). Pandemic pressure was proxied by the number of COVID-19-related deaths per country, retrieved from the Coronavirus Resource Centre at Johns Hopkins University. Panel data regression including individual- and time-fixed effects was used to study the association between country-level COVID-19-related deaths over the past 14 days and individual-level self-reported well-being over the past 14 days.ResultsThe 7808 participants completed a total of 125 409 WHO-5 records over the study period. We found a statistically significant inverse relationship between the number of COVID-19-related deaths and the level of psychological well-being—independent of running activity and running injuries (a reduction of 1.42 WHO-5 points per COVID-19-related death per 10 000 individuals, p<0.001).ConclusionsThis study suggests that the COVID-19 pandemic has had a negative effect on the psychological well-being of the affected populations, which is concerning from a global mental health perspective.
Negotiating the polypharmacy paradox: a video-reflexive ethnography study of polypharmacy and its practices in primary care
Authors: Swinglehurst Deborah , Hogger Lucie , Fudge Nina 
Published: September 2022

BackgroundPolypharmacy is an important safety concern. Medication reviews are recommended for patients affected by polypharmacy, but little is known about how they are conducted, nor how clinicians make sense of them. We used video-reflexive ethnography (VRE) to: illuminate how reviews are conducted; elicit professional dialogue and concerns about polypharmacy; invite new transferable understandings of polypharmacy and its management.MethodsWe conducted 422 hours of fieldwork (participant observation), filmed 18 consultations between clinicians and patients receiving 10 or more regular items of medication (so-called ‘higher risk’ polypharmacy) and played short clips of film footage to 34 participants (general practitioners, nurses, clinical pharmacists, practice managers) in seven audio-recorded reflexive workshops. Our analysis focused on ‘moments of potentiation’ and traced clinicians’ shifting understandings of their practices.ResultsParticipants rarely referenced biomedical aspects of prescribing (eg, drug-drug interactions, ‘Numbers Needed to Treat/Harm’) focussing instead on polypharmacy as an emotional and relational challenge. Clinicians initially denigrated their medication review work as mundane. Through VRE they reframed their work as complex, identifying polypharmacy as a delicate matter to negotiate. In patients with multimorbidity and polypharmacy it was difficult to disentangle medication review from other aspects of patients’ medical care. Such conditions of complexity presented clinicians with competing professional obligations which were difficult to reconcile. Medication review was identified as an ongoing process, rather than a discrete ‘one-off’ activity. Meaningful progress towards tackling polypharmacy was only possible through small, incremental, carefully supported changes in which both patient and clinician negotiated a sharing of responsibility, best supported by continuity of care.ConclusionsSupporting acceptable, feasible and meaningful progress towards addressing problematic polypharmacy may require shifts in how medication reviews are conceptualised. Responsible decision-making under conditions of such complexity and uncertainty depends crucially on the affective or emotional quality of the clinician-patient relationship.
Application of ₦- Hyper Set on β−Algebra
Authors: Muralikrishna P. , Hemavathi P. , Saeid Arsham Borumand 
Published: September 2022

The concept of ₦-structures was initiated by Jun et al. in 2009. Later, Young Bae Jun extended this concept as ₦-hyper sets and dealt its associated outcomes. In particular, four types of ₦-substructures with relevant properties have been investigated which leads to the introduction of the notion of ₦-hyper [Formula: see text]subalgebra in this study. Further, it was proved that the intersection of two ₦-hyper [Formula: see text]subalgebras is again an ₦-hyper [Formula: see text]subalgebra. In addition to that, the properties based on the homomorphism and Cartesian product were discussed.
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia
Authors: Liu Yiman , Li Qinglan , Alikarami Fatemeh , Barrett Declan R. , Mahdavi Leila , Li Hangpeng , Tang Sylvia , Khan Tanweer A. , Michino Mayako , Hill Connor , Song Lele , Yang Lu , Li Yuanyuan , Pokharel Sheela Pangeni , Stamford Andrew W. , Liverton Nigel , Renzetti Louis M. , Taylor Simon , Watt Gillian F. , Ladduwahetty Tammy , Kargman Stacia , Meinke Peter T. , Foley Michael A. , Shi Junwei , Li Haitao , Carroll Martin , Chen Chun-Wei , Gardini Alessandro , Maillard Ivan , Huggins David J. , Bernt Kathrin M. , Wan Liling 
Published: September 2022

Abstract

The chromatin reader eleven–nineteen leukemia (ENL) has been identified as a critical dependency in acute myeloid leukemia (AML), but its therapeutic potential remains unclear. We describe a potent and orally bioavailable small-molecule inhibitor of ENL, TDI-11055, which displaces ENL from chromatin by blocking its YEATS domain interaction with acylated histones. Cell lines and primary patient samples carrying MLL rearrangements or NPM1 mutations are responsive to TDI-11055. A CRISPR-Cas9–mediated mutagenesis screen uncovers an ENL mutation that confers resistance to TDI-11055, validating the compound's on-target activity. TDI-11055 treatment rapidly decreases chromatin occupancy of ENL-associated complexes and impairs transcription elongation, leading to suppression of key oncogenic gene expression programs and induction of differentiation. In vivo treatment with TDI-11055 blocks disease progression in cell line– and patient-derived xenograft models of MLL-rearranged and NPM1-mutated AML. Our results establish ENL displacement from chromatin as a promising epigenetic therapy for molecularly defined AML subsets and support the clinical translation of this approach.

Significance:
AML is a poor-prognosis disease for which new therapeutic approaches are desperately needed. We developed an orally bioavailable inhibitor of ENL, demonstrated its potent efficacy in MLL-rearranged and NPM1-mutated AML, and determined its mechanisms of action. These biological and chemical insights will facilitate both basic research and clinical translation.
This article is highlighted in the In This Issue feature, p. 2483
Tradução de "Dissertação sobre a política dos romanos na religião", de Montesquieu
Authors: Santos Igor Moraes 
Published: September 2022

Tradução do texto originalmente intitulado "Dissertation sur la politique des Romains dans la religion", de Charles-Louis de Secondat, barão de La Brède e de Montesquieu. Trata-se de trabalho apresentado no dia 18 de junho de 1716 à Academie Royale des Sciences, Belles-Lettres et Arts de Bordeaux e somente publicado após a sua morte.
Friendly Assistance and Self-Reliance
Authors: Vámos Péter 
Published: September 2022

Abstract
Advanced geophysical techniques developed in Hungary contributed immensely to the success of geological surveys carried out in the PRC after 1956. A group of Hungarian geophysicists played a pivotal role in discovering and exploring oil deposits in the Songliao Basin, which later became known as Daqing, the largest oil field in China. Based on declassified primary sources from Hungarian archives and firsthand testimony from people involved in the expedition, this article examines how Sino-Hungarian cooperation in Cold War activities evolved against the backdrop of the radicalization of Chinese politics and growing tensions between the Soviet Union and China. Taking the Hungarian geophysicists’ expedition as an example, the article explores the historical setting of early exchanges and the daily practice of scientific and technological interactions between the PRC and one of the closest East European allies of the Soviet Union.
“We Were as Dreamers:” Prayer as the Royal Road to the Unconscious in Hasidism
Authors: Moseson Elly 
Published: September 2022

Abstract
This study explores the Hasidic psychologization of Jewish mysticism by focusing on the problem of distracting thoughts that arise during prayer, and the attitudes and responses to them that can be found in Hasidic literature. Two different theories of the origins of such thoughts, both attributed to Israel Ba’al Shem Tov, along with various techniques for engaging with them, are described. It is argued that these theories reflect two distinct paradigms, both of which exhibit significant similarities to the dynamic unconscious of psychoanalysis. In addition to tracing the reception of Israel’s ideas on distracting thoughts within the Hasidic movement and without, the study connects them to his activities as a folk healer with a particular concern with treating mental illness.
Transfer of four isolates of Bursaphelenchus doui into Monochamus alternatus and potential vector switching of the nematode
Authors: Maehara Noritoshi , Aikawa Takuya , Kanzaki Natsumi , Nakamura Katsunori 
Published: September 2022

Summary
To reinforce vector-switching potential of Bursaphelenchus doui in its ecological and evolutionary contexts, we tested our previous hypothesis that “B. doui (or its ancestor) was transferred by Acalolepta fraudatrix, Acalolepta sejuncta, and/or Monochamus subfasciatus (or their ancestral species) from broad-leaved trees to conifers, switched vectors from these cerambycid beetles to Monochamus beetles in conifers, and then evolved into the common ancestor of Bursaphelenchus mucronatus and Bursaphelenchus xylophilus”. The affinity of four B. doui isolates and one B. xylophilus isolate for Monochamus alternatus was tested using our simple nematode-loading method to the beetle, and the affinity was assessed based on the nematode loads on the beetles. Phoretic stages of two B. doui isolates obtained from Monochamus saltuarius and Pinus densiflora showed loading levels similar to that of B. xylophilus, which were significantly higher than those of the other two B. doui isolates obtained from A. fraudatrix and M. subfasciatus. This result indicates that the first two isolates of B. doui derived from a conifer-using beetle and a coniferous tree adapt to M. alternatus better than the last two isolates associated with beetles using broad-leaved trees. The data reinforce that vector switching of B. doui could have occurred during the evolutionary history of the B. xylophilus group.
Relationship Between the Progression of Coronary Artery Disease and Pulse Pressure Index: A Cross-Sectional Work
Authors: Karadavut Serhat , Kelesoglu Saban , Elcik Deniz 
Published: September 2022

This study sought to analyze the relationship between pulse pressure (PP) index (PPI) (PP/systolic blood pressure; a less variable and objective form of PP) and coronary artery disease (CAD) progression. A registry of 193 patients was evaluated to show CAD progression by comparing current vs previous (6 months to 3 years prior) angiograms. One day after the second angiogram, we conducted ambulatory blood pressure measurements on the patients. Of the 193 patients, 65 (34%) had CAD progression. The PP and PPI were significantly higher in the progression than in the non-progression group (55 ± 12 vs. 51 ± 10 mmHg, P = .02 and .47 ± .06 vs. .42 ± .05, P = .004, respectively). Also, the PP and PPI were independently predictive of CAD progression (OR = 1.03, P = .03 and OR = 6.47, P = .01, respectively). Moreover, the correlation of PPI with low-density lipoprotein cholesterol and glycosylated hemoglobin was greater than their correlation with PP. In addition, PPI predicted CAD progression better than PP (area under the curve [AUC] = .649 vs. .574, P = .03). Elevated PP and PPI may be associated with the progression of CAD. PPI seems more successful in predicting CAD progression than PP.