bluuebunny/crossref_metadata_2025_split huggingface dataset:
The lived experiences of parents providing care to young people who self‐harm: A meta‐aggregative synthesis of qualitative studies
Authors: Zhao Yan‐li , Liu Zhi‐hua , Li Ying‐ying , Liu Dong‐ling , Yi Jing‐na 
Published: November 2022

AbstractSelf‐harm, which affects the whole family system, is an international public health concern. Empirical evidence supports the efficacy of interventions incorporating a family/parent training component for self‐injurious thoughts and behaviours, and a quantitative synthesis of these empirical studies has been undertaken and updated. A qualitative synthesis of the experiences of parents whose child self‐harms remains limited. This report aimed to systematically review qualitative research about the experiences, preferences, and expectations of parents whose children self‐harmed. A comprehensive search was conducted across ten databases and four grey literature sources, along with the manual search of reference lists and relevant websites. Study screening, data extraction, and quality appraisal were all performed by two independent researchers. Twenty‐four articles, two of which were mixed‐methods studies, were included and analysed using a meta‐aggregation approach. Five synthesized findings were identified: initial negative reactions to the discovery of their child's self‐harm, the ongoing impact of self‐harm on parents and the wider family, parents' various coping strategies, parents' negative experiences with mental health professionals expectations, and the lack of and need for psychoeducational resources. Our review finds that parents express keen interest in engaging with the treatment process, and our results support family‐based therapy. However, with the overwhelming emotions most parents experience, clinicians should approach them with sensitivity, empathy and finesse. Psychoeducational self‐help resources should also be made readily available to parents who are reluctant to seek help.
Exploring adaptations to the clinical reasoning cycle for forensic mental health nursing: A qualitative enquiry
Authors: Maguire Tessa , Garvey Loretta , Ryan Jo , Levett‐Jones Tracy , Olasoji Michael , Willetts Georgina 
Published: November 2022

ABSTRACTForensic mental health nurses (FMHN) provide care to address the needs of people who have mental illnesses across a range of diverse settings. The Clinical Reasoning Cycle (CRC) has been identified as a potential framework to assist FMHNs; however, adaptations were required to reflect the unique nature of the clinical setting. This study aimed to explore adaptations made to determine suitability prior to implementation in practice. Nominal Group Technique was used to explore suggested adaptations determined from a previous study and reach a consensus on the changes. Fourteen senior nurses from a state‐wide Forensic mental Health (FMH) service participated. A consensus was reached for two proposed changes. Data were analysed using thematic analysis. Three main themes were interpreted from the data; FMH adaptations are warranted, the focus of the CRC, and who owns the cycle? Nurses in this study considered the need to include offence and risk issues due to the impact these factors have on the therapeutic relationship and cognitive bias; however, they also identified the need to focus on recovery‐oriented care while engaging in clinical reasoning. Nurses in this study also expressed some reluctance for nursing to ‘own' the model, due to concern that ownership may cause division among the team or result in inconsistency in care. However, some participant's suggested the CRC with adaptations assisted FMH nurses to articulate their specialist skills and knowledge to others and highlight the nursing contribution to care. Further work is needed to finalize adaptations with a focus on engaging the consumer carer workforce and interdisciplinary team.
Effect of educational interventions on wound healing in patients with venous leg ulceration: A systematic review and meta‐analysis
Authors: Bossert Jasmin , Vey Johannes A. , Piskorski Lars , Fleischhauer Thomas , Awounvo Sinclair , Szecsenyi Joachim , Senft Jonas 
Published: November 2022

AbstractEducational interventions for patients with venous leg ulceration (VLU) may promote adherence and self‐management, however, their effect on wound healing is unclear. A systematic literature search was performed and randomised controlled trials with a focus on educational interventions were included. Wound healing was analysed by assessing wound healing rate, ulcer size, and the PUSH Score. Additional outcomes comprised pain, quality of life, and functional ability. The study protocol for this work is registered at PROSPERO 2020 (ID: CRD42021286152). Nine studies were included in this meta‐analysis. The odds ratio for wound healing was 1.91 (95% CI, 0.99–3.67, P = .053) in favour of educational interventions compared to usual care. Ulcer size reduction was higher (MD: ‐7.22; 95% CI, −11.91 to −2.53, P = .003) in patients following educational interventions. Included studies also showed significant effects on pain, quality of life, and functional analysis, though no quantitative synthesis was feasible. The overall risk of bias showed some concerns. Educational interventions aim to actively involve patients in their treatment, thereby appearing to be able to have a positive impact on wound healing within 12 weeks. Consequently, integrating educational approaches to routine wound care may be a promising strategy to improve treatment of VLU.
Recovery‐oriented mental health principles in psychiatric hospitals: How service users, family members and staff perceive the realization of practices
Authors: Anttila Minna , Lantta Tella , Hipp Kirsi , Välimäki Maritta 
Published: November 2022

AbstractAimsThe aim of the study was to describe and compare how recovery‐oriented mental health principles have been realized in Finnish psychiatric hospitals from the viewpoint of different stakeholders (service users, family members and staff).DesignA multimethod research design was adopted to combine both quantitative and qualitative descriptive methods.MethodsA total of 24 focus group interviews were conducted with service users (n = 33), family members (n = 3) and staff (n = 53) on 12 psychiatric Finnish hospital wards (October 2017). The interview topics were based on six recovery‐oriented principles (WHO QualityRights Tool Kit, 2012). A quantitative deductive analysis was conducted to describe and compare the realization of the recovery‐oriented principles between three stakeholder groups. A qualitative deductive content analysis was used to describe participants' perceptions of the realization of recovery‐oriented principles in practice. The GRAMMS guideline was used in reporting.ResultsOut of six recovery‐oriented principles, ‘Dignity and respect’ was found to have been realized to the greatest extent on the psychiatric wards. The most discrepancy between the participant groups was seen in the ‘Evaluation of recovery’. Service users and family members found the realization of the practices of all principles to be poorer than the staff members did. Wide variation was also found at the ward level between perceptions among participants, and descriptions of the realization of the principles in psychiatric hospital practice.ConclusionPerceptions about the realization of recovery‐oriented principles in practice in Finnish psychiatric hospitals vary between different stakeholder groups. This variation is linked to differing ward environments.ImpactMore research is needed to understand the factors associated with variation in perceptions of recovery principles.Patient or Public ContributionService users and family members participated in this study.
Improving Arguments for Local Carbon Rights: The Case of Forest‐Based Sequestration
Authors: Heyward Clare , Lenzi Dominic 
Published: November 2022

ABSTRACTLand‐based climate mitigation schemes such as REDD+ imply the creation of ‘rights to carbon’ for actions that enhance carbon sinks. In many cases, the legal and normative foundations of such rights are unclear. This article focuses on special rights on the basis of improvement. Considering improvement in relation to carbon sinks requires asking what it means to ‘improve’ an environmental resource. Our answer departs in two significant respects from the standard conception of improvement, namely by reconceiving action in relation to ecosystem services, and accordingly, making the case for a counterfactual baseline to be used to compare an improved and unimproved state. Our modifications potentially allow for a variety of agents to claim special carbon rights on the basis of beneficial interactions with land‐based carbon sinks. We give three archetypical examples of agents who may claim pro tanto special rights to carbon based on their interaction with carbon sinks.
De novo transcriptome analysis of the centrohelid Raphidocystis contractilis to identify genes involved in microtubule‐based motility
Authors: Ikeda Risa , Sakagami Tosuke , Hamada Mayuko , Sakamoto Tatsuya , Hatabu Toshimitsu , Saito Noboru , Ando Motonori 
Published: November 2022

AbstractThe centrohelid heliozoan Raphidocystis contractilis has many radiating axopodia, each containing axopodial microtubules. The axopodia show rapid contraction at nearly a video rate (30 frames per second) in response to mechanical stimuli. The axopodial contraction is accompanied by cytoskeletal microtubule depolymerization, but the molecular mechanism of this phenomenon has not been elucidated. In this study, we performed de novo transcriptome sequencing of R. contractilis to identify genes involved in microtubule dynamics such as the rapid axopodial contraction. The transcriptome sequencing generated 7.15‐Gbp clean reads in total, which were assembled as 31,771 unigenes. Using the obtained gene sets, we identified several microtubule‐severing proteins which might be involved in the rapid axopodial contraction, and kinesin‐like genes that occur in gene duplication. On the other hand, some genes for microtubule motor proteins involved in the formation and motility of flagella were not found in R. contractilis, suggesting that the gene repertoire of R. contractilis reflected the morphological features of nonflagellated protists. Our transcriptome analysis provides basic information for the analysis of the molecular mechanism underlying microtubule dynamics in R. contractilis.
Population genetic structure, parasite infection and somatic condition of pumpkinseed Lepomis gibbosus (Actinopterygii: Centrarchidae) in the Oder river basin
Authors: Ondračková Markéta , Tkachenko Maria Yu , Bartáková Veronika , Bryjová Anna , Janáč Michal , Zięba Grzegorz , Pyrzanowski Kacper , Kvach Yuriy 
Published: November 2022

AbstractIn Poland, distribution of non‐native pumpkinseed Lepomis gibbosus (Centrarchidae) is strictly limited to the Oder river basin, where it was introduced in the early 20th century. Recently, several populations have been found in waterbodies adjacent to the Oder, particularly in its lower reaches. In this study, we compare the genetic relatedness of populations in the Oder basin with other European populations using nuclear (microsatellite) and mitochondrial (partial cytochrome c oxidase subunit I; cox1) markers. Microsatellite analysis indicated that four populations in the lower Oder form a separate cluster, while one in the middle Oder clustered with Danubian populations, from where probably having been introduced. Microsatellite data suggested that the lower Oder populations differ from other non‐native European populations, making it impossible to estimate the source of introduction. Nevertheless, analysis of cox1 indicated that Oder pumpkinseeds belong to the same haplotype as the vast majority of European populations. Parasitological examination confirmed the presence of two North American species, the monogenean Onchocleidus dispar and trematode Posthodiplostomum centrarchi, in the lower Oder, both previously unknown in the region. Fifteen other parasite species were acquired, including glochidia of invasive Sinanodonta woodiana. In the middle Oder, parasite infection was more limited. Fish from the Gryfino Canal, considered one of the most invasive populations in Europe, showed the highest parasite abundance and diversity, and the highest somatic condition and growth rate due to warm water released from the Dolna Odra power plant. Our results highlight significant differences in somatic condition and parasite infection in long‐established non‐native pumpkinseed populations in the same river system, reflecting mainly environmental conditions.
Application of artificial intelligence to digital‐rapid on‐site cytopathology evaluation during endoscopic ultrasound‐guided fine needle aspiration: A proof‐of‐concept study
Authors: Lin Rong , Sheng Li‐Ping , Han Chao‐Qun , Guo Xian‐Wen , Wei Rong‐Gan , Ling Xin , Ding Zhen 
Published: November 2022

AbstractBackgroundDuring endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA), cytopathology with rapid on‐site evaluation (ROSE) can improve diagnostic yield and accuracy. However, ROSE is unavailable in most Asian and European institutions because of the shortage of cytopathologists. Therefore, developing computer‐assisted diagnostic tools to replace manual ROSE is crucial. Herein, we reported the validation of an artificial intelligence (AI)‐based model (ROSE‐AI model) to substitute manual ROSE during EUS‐FNA.MethodsA total of 467 digitized images from Diff‐Quik (D&F)‐stained EUS‐FNA slides were divided into training (3642 tiles from 367 images) and internal validation (916 tiles from 100 images) datasets. The ROSE‐AI model was trained and validated using training and internal validation datasets, respectively. The specificity was emphasized while developing the model. Then, we evaluated the AI model on a 693‐image external dataset. We assessed the performance of the AI model to detect cancer cells (CCs) regarding the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).ResultsThe ROSE‐AI model achieved an accuracy of 83.4% in the internal validation dataset and 88.7% in the external test dataset. The sensitivity and PPV were 79.1% and 71.7% in internal validation dataset and 78.0% and 60.7% in external test dataset, respectively.ConclusionWe provided a proof of concept that AI can be used to replace manual ROSE during EUS‐FNA. The ROSE‐AI model can address the shortage of cytopathologists and make ROSE available in more institutes.
Impact of the Care and Coercion Act on recorded involuntary care in intellectual disability care: a time‐series analysis
Authors: Bakkum L. , Bisschops E. H. , Lagerweij S. , Schuengel C. 
Published: November 2022

AbstractBackgroundOn 1 January 2020, the Care and Coercion Act came into effect in the Netherlands, subjecting involuntary care to more strict regulations and monitoring. This study tested changes in recordings of involuntary care during the transitional year of 2020 and after full implementation in 2021, which coincided with the first severe test of the new regulations, when COVID‐19 lockdown measures were taken on 16 March 2020.MethodsData consisted of weekly counts of involuntary care from 1 January 2017 to 31 December 2021, taken from the care data of more than 3000 clients with intellectual disabilities and challenging behaviour of 's Heeren Loo, a large long‐term care organisation in the Netherlands. An interrupted time series design was used to compare the period under the former law with the period under the new law and to the period during and after implementation, taking into account the impact of the COVID‐19 lockdown measures on recordings of involuntary care.ResultsUnder the new act in Week 1 of 2020, a statistically significant drop occurred in involuntary care counts, after which these counts gradually decreased. The start of 2021, the year in which the act was fully implemented, showed an initial increase in counts of involuntary care, followed by a decrease (allPs < .001). The introduction of the COVID‐19 lockdown measures did not statistically affect the weekly counts of involuntary care.ConclusionsThe decrease in registered involuntary care after the Care and Coercion Act came into effect is a first indication of the efficacy of this new law that requires careful multidisciplinary consultations around the right of clients to respect their self‐determination. Follow‐up research should examine whether the impact of the new law aligns with clients' experiences of self‐determination.
Comparing the application of various engineered xenografts for skin defects: A systematic review
Authors: Salloum Antoine , Bazzi Nagham , Squires Stephen , Chu Thomas , Benedetto Paul , Benedetto Anthony 
Published: November 2022

AbstractIntroductionXenografts are a now a cornerstone in the management of wound dressings. Promising results were achieved since 1960 in the application of skin substitute for skin defects.ObjectiveThe objective of this study was to evaluate the efficacy of various xenografts.MethodsA literature research was conducted using the following query: ‘Porcine skin dermatology substitute’, ‘bovine skin dermatology substitute’, ‘xenograft skin substitute dermatology’, ‘xenografts skin defect’, ‘porcine skin defect’, ‘bovine skin defect’.ResultsThe review yielded 35 articles pertaining to the topic. Main indications for porcine and bovine xenograft application were burn wounds and post‐traumatic wounds, respectively. Mean discharge date or length of stay was at the 6th day after porcine application, and the time of graft healing was reported for 33.7% (n = 510) of patients. Promising results were seen with Matriderm and split‐thickness skin graft. Most wounds achieved an excellent cosmetic result with full range of motion and a smooth contour appearance. A great variety of tissue substitutes exist, and the choice of graft application should depend on a patient's factors, product availability, wound type, size, and physician's factors.ConclusionIn summary, xenografts are more economic and affordable but have higher risk of infections compared to allografts.
Expert consensus on holistic skin care routine: Focus on acne, rosacea, atopic dermatitis, and sensitive skin syndrome
Authors: Goh Chee‐Leok , Wu Yan , Welsh Belinda , Abad‐Casintahan Ma Flordeliz , Tseng Chung‐Jen , Sharad Jaishree , Jung SungKyu , Rojanamatin Jinda , Sitohang Irma Bernadette S. , Chan Hau Ngai Kingsley 
Published: November 2022

AbstractBackgroundTreatment, cleansing, moisturizing, and photoprotection are four major components of holistic skin care for dermatological conditions. While treatment (T) is recognized as a key component in the management of dermatological conditions, there is a lack of practical guidance on the adjunctive role of cleansing, moisturizing, and photoprotection (“CMP”). Limited patient knowledge, confusion over product selection, and lack of guidance on how to choose and use CMP skin care products (in conjunction with pharmacological therapy) are the main barriers to establishing a holistic skin care routine for dermatological conditions.AimsThis study aimed to review current clinical evidence, identify gaps, and provide practical guidance on conceptualization and implementation of CMP routine in the management of sensitive skin due to underlying acne, atopic dermatitis, or rosacea, including conditions with idiopathic causes referred to as idiopathic sensitive skin syndrome.MethodsAn expert panel comprising of 10 dermatologists from Australia, China, Hong Kong, Taiwan, India, Indonesia, Philippines, Singapore, South Korea, and Thailand convened to develop consensus statements on holistic skin care in acne, rosacea, atopic dermatitis, and idiopathic sensitive skin syndrome using the Delphi approach.ResultsConsensus was defined as ≥80% of panel rating statement as ≥8 or median rating of ≥8. The final statements were collated to develop consensus recommendations on holistic skin care.ConclusionA dermatologist‐guided holistic skin care routine is essential to improve patient confidence and reduce confusion over product selection. The consensus recommendations presented here highlight the importance of cleansing, moisturization, and photoprotection in holistic skin care and how it can be utilized as a communication tool for physicians and patients to achieve overall better patient compliance, satisfaction, and treatment outcomes.
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids
Authors: Cohen Alexa J. , Talasila Sahithi , Lazarevic Bojan , Banner Lauren , Gleason Laura , Malkani Kabir , Uitto Jouni , Nikbakht Neda 
Published: November 2022

AbstractBackgroundKeloids are common and have significant negative effects on quality of life. There is a need for more effective treatment approaches for keloids.AimsWe investigated treatment outcomes of intralesional triamcinolone acetonide (IL TAC) compared with combination IL TAC and cryotherapy, including changes in pruritus, pain, and keloid size.Patients/MethodsWe performed a prospective study of patients referred to one provider who treated patients with combination therapy and compared them to a historic control cohort treated with IL TAC alone. All patients were seen at Thomas Jefferson University between 2019 and 2021. Patient demographics, location of keloids, and inciting events were recorded. Pruritus and pain scores were self‐reported by patients using a 10‐point Likert scale administered as standard of care. Changes in keloid size were denoted as “No change,” “up to 50% decrease,” “more than 50% decrease,” and “completely flattened.”ResultsWhile both treatments produced a significant reduction in mean pruritus and pain scores, there was no difference between the two treatment groups (p = 0.3933 and p = 0.2123, respectively). A greater percentage of keloids in the combination therapy group had a post‐treatment size difference greater than 50% compared with those in the IL TAC only treatment group (p = 0.0021). In the subgroup of pubic keloids, all lesions treated with combination IL TAC and cryotherapy responded remarkably well to treatment.ConclusionsWhile both IL TAC and IL TAC with cryotherapy were effective at reducing pruritus and pain, combination therapy was more effective in reducing keloid size, specifically for pubic keloids.
Comparison of fetal and maternal tissue elasticity between euploid and aneuploid pregnancies by shear wave elastography
Authors: Kucukbas Gokce Naz , Soylu Abdullah Ruhi 
Published: November 2022

AbstractAimB‐mode ultrasonography utilized for fetal screening of common trisomies is referred to as a genetic sonogram and includes determining major abnormalities and soft markers such as hypoplastic nasal bone and increased thickness of the nuchal fold. Elastography is a novel ultrasound technique giving information about tissue stiffness used for diagnosing cancer, transplant rejection, and organ fibrosis. This study aimed to determine via shear wave elastography (SWE) whether euploid and aneuploid fetal soft marker tissues vary in stiffness.MethodsThe participants were all singleton pregnancies between 19 and 23 weeks of gestation; 35 euploid and 14 aneuploid fetus pregnancies were enrolled. Fetal bowel, kidney, liver, nasal bone, nuchal fold, placenta, and myometrium were investigated with SWE using acoustic radiation impulse force. Images were analyzed with a novel software calibrated and written by us using MATLAB. Statistical analysis was completed with the SPSS Program. Shapiro–Wilk normality distribution analysis, Student's t‐test, and Mann–Whitney U methods were used.ResultsThe mean shear wave speed of fetal nasal bone was significantly lower in aneuploid fetuses. There was no difference between other tissues in mean shear wave velocity.ConclusionsEuploid and aneuploid fetuses have different elastic properties of the nasal bone and this may have a role in differentiating aneuploid fetuses noninvasively.