bluuebunny/crossref_metadata_2025_split huggingface dataset:
Particulate organic carbon (POC) estimation and algorithm development in northeast Arabian Sea coastal water
Authors: Sarangi R. K. , Jaiganesh S. N.N. , Patel Bimalkumar R. , Prajapati Apurva , Patel Hitesh D. 
Published: October 2022

Abstract

In situ sampling and analysis for water quality and bio-optical parameters carried out in the northeast Arabian Sea, in Diu and Daman coastal waters during February and August 2021. The in situ sampled water analysed to estimate chlorophyll, nutrients, Particulate Organic Carbon (POC) in the study area. The bio-optical parameters, normalized water leaving radiance (Lwn) and remote sensing reflectance (Rrs) retrieved with the operation of underwater hyperspectral radiometer (Satlantic/Wetlabs inc.). The main objective of the work was to develop POC algorithm using in situ radiometer derived Rrs for selected wavelengths in visible regions and linking the band ratios to in situ POC data. In Diu, total 11 stations data collected and produced POC range (44–608 mg m− 3). These 11 points POC data correlated with Rrs band ratios using 2nd order polynomial function and indicated coefficient of determination (R2 values 0.37, 0.34 and 0.13). This correlation was also made using 3rd order polynomial fit and indicated R2 values 0.41, 0.42 and 0.26. The same datasets were observed with 3-Dimensional correlation between Rrs(490/555), Rrs(443/555), Rrs(510/555) and POC using linear, paraboloid, gaussian and Lorentzian function fit, which showed improved R2 values ranging 0.34 to 0.66. The data from Daman added to Diu data (total 18 points), which resulted with further better correlation (R2 = 0.75, RMSE = 9.12) with higher range of POC upto 2600 mg/m3. The Modis-Aqua satellite derived POC data for our in situ stations for the sampling dates ranged 392–411 mg m− 3 as compared to our in situ data range 44–608 mg m− 3. Out of these different POC algorithms inter-comparison and satellite data, it is observed mandatory to have regional POC algorithms with sufficient in situ data points.
HDACs/mTOR inhibitor synergizes with pyrotinib in HER2-positive pancreatic cancer through degradation of mutant P53
Authors: Mao Tiebo , Zhang Xiaofei , Xu Haiyan , Zhang Xiao , Ge Weiyu , Li Shumin , Ma Jingyu , Yue Ming , Xue Shengbai , Cui Jiujie , Wang Liwei 
Published: October 2022

Abstract
Pancreatic ductal adenocarcinoma (PDAC), as a highly lethal malignancy with high mortality, lacks of effective treatment. Canonical therapeutic targets in PDAC demand further verification among whichHER2 receptor tyrosine kinase inhibitor pyrotinib as treatment targets has not be decided.
Methods
Anti-PDAC efficacy of pyrotinib was evaluated both in vitro and in vivo using both cell lines and patient-derived xenografts. By screening a large-scale library of 1453 compounds, we identified HDACs/mTOR inhibitor 1 as a promising candidate to synergize with pyrotinib. The combination therapy was evaluated in vitro and in vivo in multiple cell lines and animal models. Furthermore, RNA-seq analysis was performed to reveal the latent molecular mechanism of combination therapy.
Results
In our study, pyrotinib monotherapy was found to be inefficient to anti-PDAC which exhibited limited anti-proliferation effect in vitro and in vivo. Through therapy combined with HDACs/mTOR inhibitor 1, pyrotinib triggered intense apoptosis in PDAC both in cell lines and animal models. Mechanistic analyses revealed that mutant P53 degradation mediated by HDAC inhibition synergized with HER2 and mTOR inhibition.
Conclusions
In conclusion, identification of HDACs/mTOR inhibitor as a synergistic inhibitor, provides a potent therapeutic strategy that targets HER2-positive pancreatic cancer.
Comparative aerobiological study between two stations located at different points in a coastal city in southern Spain
Authors: Ruiz-Mata Rocío , Trigo María del Mar , Recio Marta , de Gálvez-Montañez Enrique , Picornell Antonio 
Published: October 2022

Abstract
Due to the increase in allergies, aerobiological studies carried out in cities are essential to keep the population informed about the pollen atmospheric concentrations detected. However, the high cost and complexity of aerobiological studies often means that the information is generated from a single sampling point what may not be representative of the entire city. So, the precision and functionality of the information and alert systems for allergy sufferers can be reduced. This effect may be increased in coastal cities or in those with an asymmetric growth. In this study, the data obtained by two volumetric pollen traps, located in the coastal city of Malaga (Spain) were analyzed. One of the pollen traps was situated in the city center while the other was in the outskirts of the city, 5 km away from the first. Despite being located within the same city, the data obtained from both collectors showed significant differences in the relative abundance and annual integrals of the main pollen types, as well as in the periods in which elapse their main pollen seasons, probably due to being located in areas with quantitative differences in land uses. These differences were more notable in the case of ornamental plants, weeds that usually appear in brownfields sites, and some taxa that predominate in the agro-forestry areas of the outskirts. For all the above, we consider that it is important to keep operational several sampling points in cities of a certain magnitude to provide more detailed information about atmospheric pollen concentrations.
Four novel large deletions and complex variants were identified in α-globin locus in Chinese population
Authors: Bao Xiuqin , Wang Jicheng , Qin Danqing , Yao Cuize , Liang Jie , Liang Kailing , Zeng Yukun , Du Li 
Published: October 2022

Abstract
Background: At present, the usual methods used to detect a-thalassemia mutations are confined to detect the common mutations, which may easy to result in misdiagnosis or missed diagnosis. Single molecule real time sequencing (SMRT) enables long-read single-molecule sequencing with high detection accuracy, and long-length DNA chain reads in high-fidelity reads mode.
Methods: Herein, we used SMRT to detect rare and complex variants in a-globin locus in four individuals whose hematological data indicated microcytic hypochromic anemia but conventional thalassemia detecting result was negative. Multiplex ligation-dependent probe amplification (MLPA) and droplet digital polymerase chain reaction (ddPCR) were used to confirm the results of SMRT.
Results: We found 4 novel large deletions ranging from 23 kb to 81 kb in a-globin locus, among which one patient also has a duplication inserted in the deletional fragment. In addition, one patient with 27.31 kb deletion on chromosome 16 (hg 38) was also detected to be abnormal hemoglobin Siriraj (Hb Siriraj).
Conclusion: We first identified the four novel deletions in a-globin locus by using SMRT. Given that conventional methods may lead to misdiagnosis or missed diagnosis, SMRT served as a good method to discover rare and complex variants in thalassemia, especially in prenatal diagnosis.
Methods for meta-analysis and meta-regression of proportions: concepts and tutorial with Stata command metapreg
Authors: Nyaga Victoria Nyawira , Arbyn Marc 
Published: October 2022

Abstract
Background: Despite the widespread use of meta-analysis of proportions, its rationale, certain theoretical and methodological concepts are poorly understood.The framework of logistic regression is well-established and provides a natural and optimal model for meta-analysis, network meta-analysis, and meta-regressionof proportions. Nonetheless, classical tools for meta-analysis of proportions based on approximation to the normal distribution continue to dominate.
Methods: We explain the rationale and concepts essential in understanding statistical methods for meta-analysis of proportions. We then present metapreg; a flexible model-based tool with advanced statistical procedures to perform ameta-analysis, network meta-analysis, and meta-regression of proportions in Stata. The tool implements the logistic and the logistic-normal regression, andmarginal standardization to yield population-averaged estimates. Finally, we demonstrate using metapreg with data from four published meta-analyses; a)cure rate of treatment for cervical pre-cancer using cold coagulation, b)incomplete excision of cervical precancer as a predictor of treatment failure, c)effect of geographical area on the protective effect of BCG vaccination againsttuberculosis and d) response rate to treatment of acute mania in adults withdiverse drugs.
Conclusion: metapreg is an efficient and user-friendly statistical tool dedicatedt o meta-analysis, network meta-analysis and meta-regression of binomial data. It allows both continuous and categorical explanatory covariates including relevant interactions to explain the variability in the proportions.
Leveraging Technology To Diagnose Alzheimer's Disease: A Meta Analysis
Authors: Kruse Clemens Scott , Mileski Michael M. , Wilkinson Reagan , Larson Britney , Samson Roger , Castillo Taylor 
Published: October 2022

Abstract

Background:About 50 million people worldwide suffered from dementia in 2018 – two-thirds of those with Alzheimer's Disease (AD). By 2050, this number is expected to rise to 152 million – which is slightly larger than the country of Russia. About 90% of these people are over the age of 65, but early-onset dementia can occur younger ages. The objective of this meta-analysis is to objectively analyze the effectiveness of health information technology to diagnose AD. We analyzed data from studies published over the last 10 years to meet this objective: Cost, efficiency, accuracy, acceptability (by physician and patient), patient satisfaction, and barriers to adoption.Methods:Four research databases were queried (PubMed, CINAHL Ultimate, Web of Science, and ScienceDirect). The study was conducted in accordance with a published protocol, the Kruse Protocol, and reported in accordance with PRISMA (2020).Results:Ten technological interventions were identified to help diagnose AD among older patients, and some involved a combination of methods (such as MRI and PET). The average sample size was 320. These 10 interventions were identified as accurate, non-invasive, non-stressful, in expensive, convenient, and rapid. Only one intervention was identified as ineffective, and this same intervention was used effectively in other studies. Barriers identified were cost, training, expense of travel, and requires physical presence of patient. The weighted average sensitivity was 85.16%, specificity was 88.53, and the weighted average effect size was 0.7339.Conclusion:Technological innovation can accurately diagnose AD, but not all methods are successful. Providers must ensure they have the proper training and familiarity with these interventions to ensure accuracy in diagnosis. While the physical presence of the patient is often required, many interventions are non-invasive, non-stressful, and relatively inexpensive.
Ethnobotanical study of medicinal plants used to treat livestock ailment in Delomena district southeast Ethiopia.
Authors: Gobana Awal Hussein , Jilo Sufian Abdo 
Published: October 2022

Abstract
Traditional knowledge on the use of medicinal plants is in danger of extinction because of different changes taking place all over the world including Ethiopia and thus there is a need for its immediate documentation for the purpose of conservation, sustainable utilization and development. Thus, an ethnobotanical study was conducted in Dalomana District, Oromia Regional State of Ethiopia to document and analyze local knowledge on medicinal plants used for the treatment of animal diseases. The overall objective of the study were to investigate ethnobotany of traditional medicinal plants used to treat livestock diseases in Dalomana district, Bale Zone, Oromia, Ethiopia. Data were collected between June, 2021 and February, 2022 mainly through semi-interviews conducted with purposively selected informants. Data collected mainly included demographic information of respondents, local names of medicinal plants, plant parts used, preparation methods, mode of applications, diseases treated, and habit and habitat of the reported plants. Based on data obtained through interviews, Informant Consensus Factor (ICF) values were computed. A total of 55 medicinal plants used to manage livestock ailment were reported by informants in the Dalomana District. Herbs were commonly used in the preparation of remedies. Leaf was the most frequently utilized plant part accounting for 49.1% of the total reported medicinal plants. The majority (69.0%) of the medicinal plants used in the study District were uncultivated ones mainly harvested from edges of forests and bushlands, roadsides, river banks and grasslands. High ICF values were obtained for ophthalmological (0.82), dermatological (0.79), febrile (0.77) and gastro-intestinal ailments (0.77). The current study shows that there is still rich traditional knowledge on the use of plants to control various animal diseases in study District. However, such claim needs to be scientifically verified with piriority given to medicinal plants used in the treatment of ailment catagories with high ICF values as such plants are considered to be good candidates for further pharmacological evaluations
Cost Benefit Analysis Of Traditional Healer A Case Study At Dalomana Town In Bale Zone Southeast Ethiopia.
Authors: Gobana Awal Hussein , Shure Hasan Abdela , Kecho Abdo Hussein , Adem Mohammed Edris , Abdurahman Taha Kedir , Jilo Sufian Abdo , Nigatu Abay 
Published: October 2022

Abstract
Traditional medicine refers to health practices, approaches, knowledge and beliefs incorporating plant, animal and mineral-based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illnesses or maintain well-being. A reconnaissance survey was conducted between March 25 to May 5, 2022. The main objective of the study intends to examine the costs of input, total income and expenditure of traditional healer and identify the economic benefits of those applications of traditional medicine for the country Dalomana Southeastern, Ethiopia. The study sites were selected depending on recommendation from elders, local authorities, and altitudinal range. Thus, the study was carried out in eight PA from two agro-climatic zones. Dallo Manna. The income they generated from their jobs is recorded. The daily income is recorded. The major incomes are direct selling of the drugs as pharmacists and amount of earns they get from diagnosis and treatment of patients. Some practitioners also sell the other products which taken with drugs such as honey and other oil. The total benefit (profits) from the job is analyzed with an average of 650.8 birr daily generated as income and annually 237542 birr is estimated to be as total profit for traditional healer. Analysis of production cost structure revealed that the highest proportion of the production costs across the lead traditional healer for used health related technology and neglect technological and coset went to cost of labor (58%) and different technological activities (22%). As opposed to the traditionally used application of technology was produce more than normal amount of birr without applications., the current study indicated that reduced uses of technology for benefits increased yield per unit area but traditional healer challenged the researchers to improve the feasibility of using reduced seed rate for both row planting and broadcasting.
Distinct time trends in colorectal cancer incidence in countries with SDI levels from 1990 to 2019: An age–period–cohort analysis for the Global Burden of Disease 2019 study
Authors: Zhang Yan , Li Pu–Heng , Ding Yu–Wei , Kong Yang , Zhu Xiao-Feng , Tian Yang , Zhang Qing–Wei 
Published: October 2022

Abstract
Introduction: The burden of colorectal cancer (CRC) plays a pivotal role in the global cancer epidemic. Our study reported the incidence trends in CRC and the associated effects of age, period, and birth cohort in 204 countries and territories over the past 30 years.
Methods:The incidence data of CRC wereextracted from the Global Burden of Disease Study (GBD) 2019. We performed the age–period–cohort (APC) model to estimate the overall annual percentage change (net drift) in the incidence rate, the annual percentage change by age group (local drift), and the relative risk (period and cohort effects) of the period and cohort in CRC during 1990–2019. This approach allows examining and distinguishing age, period, and cohort effects in incidence and potentially distinguishing colorectal cancer gaps in prevention and screening.
Results: In 2019, the incidence of CRC was 2.17 (95% UI 2.00–2.34) million, of which China, the United States of America, and Japan had the highest incidence population, accounting for 45.9% of the global population. The age–standardized incidence rate (ASIR) was 26.7 (95% UI 28.9–24.6) per 100,000 people, of which 30 countries had an incidence rate greater than 40.0 per 100,000 people. From 1990 to 2019, the middle SDI region had the largest increase in incidence rate, with a net drift of 2.33% (95% CI 2.2%–2.46%, P< 0.001). Globally, the incidence population was concentrated in the age group of 50–69 years, and the age group of 30–34 years had the largest increase in incidence rate (local drift 1.19% (95% CI 1.01%–1.37%)). At the same time, the sex and age distributions of CRC incidence had significant heterogeneity across regions and countries. In the past 30 years, the incidence rate in 31 countries has been well controlled (net drift <0), and most of them were concentrated in high–and high–middle–SDI regions, such as Australia, Czechia, and Belgium, and the relative risk of incidence generally improved over time and consecutive young birth cohorts. CRC incidence showed an unfavorable trend (net drift ≥1%) in 89 countries, of which 27 countries were more significant (net drift >2%), mostly concentrated in the middle SDI region, such as China, Mexico, and Brazil, and the risk of period and birth cohort was unfavorable.
Conclusion: Globally, the incidence of CRC has shown an overall upward trend over the past 30 years, with the exception of some countries with higher SDI values. Significant age–period–cohort differences were observed in the risk of incidence in CRC worldwide. Effective prevention and control policies need to take into account the age–period–cohort effect characteristics of different regions.
Isolated cardiac hydatid cyst in interventricular septum: a case report and literature review
Authors: Li Tiange , Ling Yunfei , Qian Yongjun 
Published: October 2022

Abstract
Background: Human hydatid disease occurs after infection with Echinococcus granulosus, mainly involves liver and lung, while hydatid involves heart is infrequent. A great majority of hydatid diseases could be asymptomatic, and incidentally found through examination. Here, we reported a woman who suffered an isolated cardiac hydatid cyst located at the interventricular septum.
Case presentation: A 48-year-old woman presented intermittent chest pain was admitted to the hospital. Imaging examination revealed a cyst located at the interventricular septum near the right ventricular apex. Considering medical history and serological results, cardiac hydatid disease was diagnosed. The cyst was successfully removed, while pathological biopsy confirmed the infection of Echinococcus granulosus. Postoperative course was uneventful, the patient was discharged from hospital without complications.
Conclusion: For symptomatic cardiac hydatid cyst, surgical resection is necessary to avoid progression of disease. During surgical procedure, appropriate methods to reduce the potential risk of hydatid cyst metastasis are essential. Besides surgery, combined with regular drug therapy is an effective strategy to prevent reappearance.
The dielectric property and thermal conductivity properties of epoxy composite filled by P-CdS with patterned surface structure
Authors: Yang Juxiang , Jia Yuan , Li Xiaoyan , Li BeiBei , Sun Ping 
Published: October 2022

Abstract
In order to endow epoxy resins (EP) with good thermal conductivity under the condition of maintaining its good dielectric properties, the new poly(N-isopropylacrylamide-co-methacrylic acid)(P(NIPAM-co-MAA))/CdS (P-CdS) microspheres with patterned surface structures was synthesized by reverse suspension polymerization technique and exogenous deposition method using the P(NIPAM-co-MAA) microgels as the template. The P-CdS microspheres with patterned surface structure were then used as modifier to prepare the P-CdS/EP composites. The chemical structure and surface morphologies of the prepared P-CdS and P-CdS/EP composites were characterized by the SEM, XRD and TGA, and influence of the P-CdS content on the dielectric properties, thermal conductivity and thermal resistant properties of P-CdS/EP composites were also studied. The results showed that the slight addition of P-CdS can highly improve the thermal conductivity and thermal resistance of P-CdS/EP composites, as well as endow EP with high dielectric constant and low dielectric loss at high frequencies. This phenomenon can be attributed to the good dispersibility and excellent electrothermal properties of P-CdS. The purpose of this study is aiming to lay a foundation for the microelectronic components application of EP in high frequency.
Accuracy and precision of certified Glucometer-Strips System Contour Plus One in clinical practice
Authors: Chlup Rudolf , Zálešáková Hana , Doubravová Blanka , Ďurajková Emilia , Nezval Martin , Gottwaldová Jiřina , Zapletalová Jana 
Published: October 2022

Abstract
Aims 1.To revise the accuracy and precision of glucometer-strips system (GSS) in a professional routine. 2. To support the feasibility of capillary plasma glucose (cPG) monitoring.
Methods Prospective single-centre study. Triplets of cPG were investigated on GSS Contour Plus One (Ascensia, Switzerland) using glucosedehydrogenase strips. To obtain one triplet, one LOT of strips was used in three glucometers Contour Plus One. Following the cPG readings, venous blood was taken into a Grainer tube to measure venous plasma glucose (vPG) on Cobas Integra 400 analyzer using hexokinase. Software IBM SPSS Statistics for Windows, V. 23.0 was applied. A total of 258 pairs of cPG vs vPG were compared using Wilcoxon signed rank test with Bonferroni correction. P<0.05 was considered significant. Precision was estimated using SD of average differences between individual cPG measurements.
Results Deviations of cPG measured on GSS Contour Plus One from vPG (in range ≥5.55 mmo/L) measured on Cobas Integra Analyser were -0.63±0.71 mmol/L (mean±SD). Number of cPG values measured on Contour Plus One within the required interval ±15% of vPG values was 200/207 (96.6%). For vPG <5.55 mmol/L the required interval of ±0.83 mmol/L was reached in 51/51 (100%) cPG values measured on GSS Contour Plus One. PG precision/variability in triplets of GSS Contour Plus One was demonstrated by SD 0.204±0.247 mmol/L.
Conclusions Required accuracy and precision of GSS Contour Plus One in clinical practice was confirmed and corresponds to the Requirements for blood-glucose monitoring systems for self-testing in managing diabetes mellitus ISO 15197 (2015). In addition to sustainable reviews of registered GSS also experienced data communication between health care professionals and GSS users should be considered.