bluuebunny/crossref_metadata_2025_split huggingface dataset:
A TiO2 Nanotube Coating Based TENG with Self‐Healable Triboelectric Property for Energy Harvesting and Anti‐Corrosion
Authors: Liu Yupeng , Sun Weixiang , Feng Min , Li Tinghua , Wang Daoai 
Published: August 2022

AbstractAs a new sustainable energy utilization way, triboelectric nanogenerators (TENGs) have attracted increasing attention in recent years. Herein, a new TiO2 nanotube coating based TENG (TNC‐TENG) with corrosion resistance and self‐healable electrical output properties for energy harvesting is developed. The inorganic coating is prepared by anodic oxidation (AO) and fluoridation with titanium. The TiO2 nanotube coating based TENG has a current output of 17.4 µA and a voltage output of 220 V. The fluorinated titanium oxide nanotubes coating has good hydrophobicity. When the fluorine composition on the coating surface is damaged by plasma, the triboelectric current decreases to 7 µA. The self‐healable hydrophobicity and electrical output property are achieved by transferring loaded perfluorosilane to the damaged surface. In addition, the electric energy generated in the triboelectrification can improve the anticorrosion performance for metal matrix by cathodic protection. Based on the corrosion resistance and self‐healing properties, the TNC‐TENG has potential applications in the field of energy collection, energy supply, and corrosion protection.
Vinylogous Hydrazone Strategy in Stereoselective Synthesis of 2,3‐Dihydro‐1H‐pyrrolizines – An Organocatalytic, Metal‐Free Route to Ketorolac
Authors: Kowalska Justyna , Łukasik Beata , Frankowski Sebastian , Sieroń Lesław , Albrecht Łukasz 
Published: August 2022

AbstractIn this paper, the application of organocatalysis in the synthesis of 2,3‐dihydro‐1H‐pyrrolizines is demonstrated. α,β‐Unsaturated aldehydes and pyrrole‐based hydrazone readily participated in the formal (3+2)‐cycloaddition that was realized according to aminocatalytic iminium ion activation. Products were obtained in high chemical yields, with excellent stereocontrol. The developed method was utilized in the first organocatalytic synthesis of ketorolac, a non‐steroidal anti‐inflammatory drug.magnified image
Cu(OTf)2‐Catalyzed Aerobic Cycloisomerization of Alkenyl Sulfones to Furans Using (E)‐β‐Chlorovinyl Ketones and Sodium Sulfinates
Authors: Bhatt Divya , Young Kim Hun , Oh Kyungsoo 
Published: August 2022

AbstractSodium sulfinate addition to (E)‐β‐chlorovinyl ketones followed by the aerobic cycloisomerization of alkenyl sulfone intermediates has been established for the synthesis of 3‐sulfonyl furans. The optimal cycloisomerization catalyst system was identified to be Cu(OTf)2, where molecular oxygen acts as a terminal oxidant. With three points of structural variation in both β‐chlorovinyl ketones and sodium sulfinates, the current aerobic cycloisomerization strategy allows the synthesis of highly functionalized and substituted furan derivatives.magnified image
Over 19.2% Efficiency of Organic Solar Cells Enabled by Precisely Tuning the Charge Transfer State Via Donor Alloy Strategy
Authors: Gao Jinhua , Yu Na , Chen Zhihao , Wei Yanan , Li Congqi , Liu Tianhua , Gu Xiaobin , Zhang Jianqi , Wei Zhixiang , Tang Zheng , Hao Xiaotao , Zhang Fujun , Zhang Xin , Huang Hui 
Published: August 2022

AbstractThe large energy loss (Eloss) is one of the main obstacles to further improve the photovoltaic performance of organic solar cells (OSCs), which is closely related to the charge transfer (CT) state. Herein, ternary donor alloy strategy is used to precisely tune the energy of CT state (ECT) and thus the Eloss for boosting the efficiency of OSCs. The elevated ECT in the ternary OSCs reduce the energy loss for charge generation (ΔECT), and promote the hybridization between localized excitation state and CT state to reduce the nonradiative energy loss (ΔEnonrad). Together with the optimal morphology, the ternary OSCs afford an impressive power conversion efficiency of 19.22% with a significantly improved open‐circuit voltage (Voc) of 0.910 V without sacrificing short‐cicuit density (Jsc) and fill factor (FF) in comparison to the binary ones. This contribution reveals that precisely tuning the ECT via donor alloy strategy is an efficient way to minimize Eloss and improve the photovoltaic performance of OSCs.
Sacral abnormalities including caudal appendage, skeletal dysplasia, and prenatal cardiomyopathy associated with a pathogenic TAB2 variant in a 3‐generation family
Authors: Koene Saskia , Klerx‐Melis Floortje , Roest Arno Anne Willem , Kleijwegt Maarten Cornelis , Bootsma Marianne , Haak Monique C. , van Haeringen Meike Heleen , Ruivenkamp Claudia Antoinette Laetitia , Nibbeling Esther Anne Rieky , van Haeringen Arie 
Published: August 2022

AbstractHaplo‐insufficiency of the TGFβ‐activated kinase 1 binding protein 2 (TAB2) gene is associated with short stature, facial dysmorphisms, connective tissue abnormalities, hearing loss, and cardiac disease. Skeletal dysplasia and sacral dimples are also found in a minority of patients. Here, we describe a 3‐generation family with caudal appendage, other sacral anomalies, and skeletal abnormalities including hypoplasia of the iliac wings and scapulae, fusion of the carpal bones and stenosis of the spinal canal, as well as a remarkable course of prenatally‐detected cardiomyopathy with characteristics changing over time. Genetic analysis showed a heterozygous nonsense variant in the TAB2 gene.
Automated age‐at‐death estimation by cementochronology: Essential application or additional complication?
Authors: Bertrand Benoit , Vercauteren Martine , Cunha Eugenia , Bécart Anne , Gosset Didier , Hédouin Valery 
Published: August 2022

AbstractIt has been repeatedly acknowledged that age‐at‐death estimation based on dental cementum represents a partial and time‐consuming method that hinders adoption of this histological approach. User‐friendly micrograph analysis represents a growing request of cementochronology. This article evaluates the feasibility of using a module to accurately quantify cementum deposits and compares the module's performance to that of a human expert. On a dental collection (n = 200) of known‐age individuals, precision and accuracy of estimates performed by a developed program (101 count/tooth; n = 20,200 counts) were compared to counts performed manually (5 counts/tooth; n = 975 counts). Reliability of the software and agreement between the two approaches were assessed by intraclass correlation coefficient and Bland Altman analysis. The automated module produced reliable and reproducible counts with a higher global precision than the human expert. Although the software is slightly more precise, it shows higher sensitivity to taphonomic damages and does not avoid the trajectory effect described for age‐at‐death estimation in adults. Likewise, for human counts, global accuracy is acceptable, but underestimations increase with age. The quantification of the agreement between the two approaches shows a minor bias, and 94% of individuals fall within the intervals of agreement. Automation gives an impression of objectivity even though the region of interest, profile position and parameters are defined manually. The automated system may represent a time‐saving module that can allow an increase in sample size, which is particularly stimulating for population‐based studies.
Workflow Times and Outcomes in Patients Triaged for a Suspected Severe Stroke
Authors: García‐Tornel Álvaro , Seró Laia , Urra Xabier , Cardona Pere , Zaragoza Josep , Krupinski Jerzy , Gómez‐Choco Manuel , Sala Natalia Mas , Catena Esther , Palomeras Ernest , Serena Joaquin , Hernandez‐Perez Maria , Boned Sandra , Olivé‐Gadea Marta , Requena Manuel , Muchada Marian , Tomasello Alejandro , Molina Carlos A. , Salvat‐Plana Mercè , Escudero Mar , Jimenez Xavier , Davalos Antoni , Jovin Tudor G. , Purroy Francesc , Abilleira Sonia , Ribo Marc , de la Ossa Natalia Perez ,   for the RACECAT trial investigators
Published: August 2022

IntroductionCurrent recommendations for regional stroke destination suggest that patients with severe acute stroke in non‐urban areas should be triaged based on the estimated transport time to a referral thrombectomy‐capable center.MethodsWe performed a post hoc analysis to evaluate the association of pre‐hospital workflow times with neurological outcomes in patients included in the RACECAT trial. Workflow times evaluated were known or could be estimated before transport allocation. Primary outcome was the shift analysis on the modified Rankin score at 90 days.ResultsAmong the 1,369 patients included, the median time from onset to emergency medical service (EMS) evaluation, the estimated transport time to a thrombectomy‐capable center and local stroke center, and the estimated transfer time between centers were 65 minutes (interquartile ratio [IQR] = 43–138), 61 minutes (IQR = 36–80), 17 minutes (IQR = 9–27), and 62 minutes (IQR = 36–73), respectively. Longer time intervals from stroke onset to EMS evaluation were associated with higher odds of disability at 90 days in the local stroke center group (adjusted common odds ratio (acOR) for each 30‐minute increment = 1.03, 95% confidence interval [CI] = 1.01–1.06), with no association in the thrombectomy‐capable center group (acOR for each 30‐minute increment = 1.01, 95% CI = 0.98–1.01, pinteraction = 0.021). No significant interaction was found for other pre‐hospital workflow times. In patients evaluated by EMS later than 120 minutes after stroke onset, direct transport to a thrombectomy‐capable center was associated with better disability outcomes (acOR = 1.49, 95% CI = 1.03–2.17).ConclusionWe found a significant heterogeneity in the association between initial transport destination and neurological outcomes according to the elapse of time between the stroke onset and the EMS evaluation (ClinicalTrials.gov: NCT02795962). ANN NEUROL 2022;92:931–942
Comprehension of Jet Physics from the Analysis of the Gamma‐Ray Burst Afterglow Parameter Distributions
Authors: Berretta Alessandra , Cristarella Orestano Paolo , Cutini Sara , Germani Stefano , Mereu Isabella , Punturo Michele , Tosti Gino 
Published: August 2022

AbstractThe discovery of a short gamma‐ray burst (GRB), GRB170817A, in association with a gravitational wave (GW) and a bright kilonova started a new era in the high‐energy astrophysics. The observation of GRB170817A and more recently, GRB200826A and GRB211211A, a short and a long burst, respectively, with a possible kilonova, reinforce the concern about new ways of classification. For this reason, a new machine learning technique is applied to Swift‐BAT data, searching for morphological similarities in the light curves. The resulting map is characterized by two distinct groups, although still correlated with standard T90 duration. Since a jet viewed off‐axis could explain the emission from GRB170817A, the modeling of this kind of sources is of great importance. A public code called JetFit, based on the “boosted fireball” model, is applied to fit Swift‐XRT afterglow light curves of short and long GRBs, with known red‐shift, from 2005 to 2021. JetFit does not model the flaring activity. For this purpose, a new technique to remove the time flaring phases, is developed. This analysis provides a comprehensive study of the prompt and of the afterglow phase, trough the study of the best‐fit parameters.
Construction of Ultrastable Nonsubstituted Quinoline‐Bridged Covalent Organic Frameworks via Rhodium‐Catalyzed Dehydrogenative Annulation
Authors: Zhao Xiaodong , Pang Huaji , Huang Dekang , Liu Gang , Hu Jianxiang , Xiang Yonggang 
Published: August 2022

AbstractExploring new routes to lock the dynamic C=N bonds in imine‐linked covalent organic frameworks (COFs) is highly desired for enhancing their stability and functionality. Herein, a novel C=N bridge locking strategy via rhodium‐catalyzed [4+2] annulation is developed to construct nonsubstituted quinoline‐linked COFs (NQ‐COFs). The notable feature of this strategy includes high C=N conversion efficiency, oxidant‐free, and generality for synthesis of a variety of NQ‐COFs with high chemical stability. Particularly, after post‐synthetic modification, the crystallinity, topology, and porosity of pristine imine‐linked COFs are well retained. When used as photocatalysts, NQ‐COFs display better visible light absorption and carriers’ separation efficiency due to enhanced in‐plane π conjugation ability, as well as more facile generation of superoxide anion radicals than their counterparts, thus leading to efficient synthesis of 2,4,6‐tris(aryl)pyridines, benzimidazole, and sulfoxide derivatives.
Terminal and Super‐Basic Parent Imides of Hafnium
Authors: Bhunia Mrinal , Sandoval‐Pauker Christian , Jafari Mehrafshan G. , Grant Lauren N. , Gau Michael R. , Pinter Balazs , Mindiola Daniel J. 
Published: August 2022

AbstractA dinuclear hafnium complex containing the parent imido ligand [(PN)(PNC)Hf=NH{μ2‐K}]2 (2) (PN−=(N‐(2‐PiPr2‐4‐methylphenyl)‐2,4,6‐Me3C6H2; PNC2−=(N‐(2‐PiPr2‐4‐methylphenyl)‐2,4,6‐CH2Me2C6H2), was prepared by reduction of the bisazide trans‐[(PN)2Hf(N3)2] (1) with two equiv of KC8. Encapsulation of K+ in 2 with crown‐ether or cryptand affords the first discrete salt [K(encap)][(PN)(PNC)Hf≡NH] (encap=18‐crown‐6(THF)2, 3; 2,2,2‐Kryptofix, 4), featuring a terminal parent imide and possessing some of the shortest Hf−N bond lengths known to date. DFT calculations revealed formation of 2 to proceed via an extremely basic monomeric nitrido, [(PN)2Hf≡N]−(A), having a computed pKBH+ of ∼57 followed by heterolytic splitting of an inert 1,2‐CH bond of a benzylic methyl group across the Hf≡N triple bond in A. An electronic structure analysis reveals A to possess a covalent Hf≡N triple bond and of super‐basic character. We also showcase reactivity of the Hf≡NH bond with various electrophiles.
Substrate‐Rhodium Cooperativity in Photoinducedortho‐Alkynylation of Arenes
Authors: Saha Argha , Ghosh Animesh , Guin Srimanta , Panda Sanjib , Mal Dibya Kanti , Majumdar Abhirup , Akita Munetaka , Maiti Debabrata 
Published: August 2022

AbstractIn the realm of metallaphotocatalytic C−H activation strategy, the direct excitation of the transition metal which plays the dual role of light energy harnessing alongside performing the bond breaking and forming is a rare phenomenon. In this context we have developed the first photo‐induced Rh‐catalyzedortho‐alkynylation under ambient conditions without the requirement of silver salt, photocatalyst (PC) or any engineered substrate or catalyst. The transformation functions by the specific cooperative effect of a six‐membered rhodacycle which is the photo‐responsive species. The catalytic system allows the conjugation of arenes with sp3‐rich pharmacophoric fragments. The control experiments as well as the computational studies resolve the mechanistic intricacies for this transformation. An outer sphere electron transfer process from Rh to alkynyl radical is operative for the present photo‐induced transformation over the more common oxidative addition or 1,2‐migratory insertion pathways.
Surface Boron Modulation on Cobalt Oxide Nanocrystals for Electrochemical Oxygen Evolution Reaction
Authors: Yu Mingquan , Weidenthaler Claudia , Wang Yue , Budiyanto Eko , Onur Sahin Ezgi , Chen Minmin , DeBeer Serena , Rüdiger Olaf , Tüysüz Harun 
Published: August 2022

AbstractHerein, we show that coupling boron with cobalt oxide tunes its structure and significantly boost its electrocatalytic performance for the oxygen evolution reaction (OER). Through a simple precipitation and thermal treatment process, a series of Co−B oxides with tunable morphologies and textural parameters were prepared. Detailed structural analysis supported first the formation of an disordered and partially amorphous material with nanosized Co3BO5and/or Co2B2O6being present on the local atomic scale. The boron modulation resulted in a superior OER reactivity by delivering a large current and an overpotential of 338 mV to reach a current density of 10 mA cm−2in 1 M KOH electrolyte. Identical location transmission electron microscopy and in situ electrochemical Raman spectroscopy studies revealed alteration and surface re‐construction of materials, and formation of CoO2and (oxy)hydroxide intermediate, which were found to be highly dependent on crystallinity of the samples.
“A weird culture of coercion”: The impact of health care corporatization on clinicians
Authors: Rudden Marie G. 
Published: August 2022

AbstractThis paper describes the nature of today's corporatized health care system in the United States, offering examples of the psychological toll it takes on clinicians at all levels. It details corporate practices that disenfranchise practitioners from exercising their clinical judgment and from offering input to system administrators about problematic patient care experiences. It discusses the sense of frustration, resignation and moral injury that can permeate their work lives and disrupt their sense of effectiveness and well‐being in this context. Following this background is a psychoanalytic analysis of narratives from two physicians about their corporate health care experiences. Two case studies follow, in which a nurse and a physician entered psychoanalytic psychotherapy to process the destructive psychological impact of their work environments. A third case illustrates the negative impact of automatized insurance practices on one psychologist and her patient.
Oropharyngeal cavity floor morphology in Eretmochelys imbricata (Testudines: Cheloniidae) hatchlings and evolutionary implications
Authors: Oliveira Radan Elvis Matias de , Attademo Fernanda Loffler Niemeyer , Sousa Ana Caroline Freitas Caetano de , Magalhães Marcela dos Santos , Oliveira Rysónely Maclay de , de Moura Carlos Eduardo Bezerra , Silva Alexandre Rodrigues , Pereira Alexsandra Fernandes , Fragoso Ana Bernadete Lima , Silva Flávio José de Lima , Oliveira Moacir Franco de 
Published: August 2022

AbstractMorphological studies of the oropharyngeal cavity of chelonians have become an interesting tool in the understanding of evolutionary processes associated with feeding habits in aquatic animals and the transition from aquatic to terrestrial forms. In this context, the aim of the present study was to describe the oropharyngeal cavity floor morphology of hawksbill sea turtle (Eretmochelys imbricata) hatchlings. Ten dead hatchlings of undefined sex were obtained from nests hatched on the coast of the state of Rio Grande do Norte, Brazil. The heads of each specimen were fixed, dissected, and analyzed at the macroscopic and microscopic levels. The oropharyngeal cavity floor of the hawksbill sea turtle hatchlings is formed by the tongue, pharynx, floor muscles, and hyolingual skeleton, delimited in the rostral and lateral directions by a keratinized beak, called the rhamphotheca, and in the caudal region at the limit between the pharynx and the esophagus. The tongue muscles and the muscles that support the floor of the oral cavity comprise the following: m. hypoglossohyoideus, m. hypoglossoglossus, m. hyoglossus, m. genioglossus, m. constrictor laryngis, m. geniohyoideus pars lateralis, and m. intermandibularis. The oropharyngeal cavity floor mucosa is formed by keratinized stratified squamous epithelium and the lamina propria is formed by loose connective tissue. The floor mucosa is devoid of taste buds. We believe that the basic oropharyngeal cavity floor characteristics in hawksbill sea turtle hatchlings may comprise indications that these animals are plesiomorphic and that semiaquatic and terrestrial turtles may have undergone adaptations to feed out of water.
Development and validation of novel RP‐HPLC method for midostaurin determination using analytical quality by design approach from regulatory perspective and determination of major degradation compounds of midostaurin using LC–MS
Authors: Reddy Saddala Madhu Prakash , Konduru Naresh , Gundla Rambabu , Kowtharapu Leela Prasad 
Published: August 2022

AbstractMidostaurin (MTN), designated as an orphan medicinal product, is emerging as an important drug for treating acute myeloid leukemia and advanced systematic mastocytosis. The proposed method was developed and validated to evaluate the related impurities of MTN. The impurities were separated using a YMC Trait C18 ExRS column (150 × 4.6 mm, 3 μm). Mobile phase A consisted of a 10‐mM concentration of phosphate buffer adjusted to pH 3.0 with diluted orthophosphoric acid, and mobile phase B consisted of 90% acetonitrile and 10% water. The optimized chromatographic conditions were as follows: flow rate, 0.5 mL min−1; injection volume, 10 μL; UV detection, 290 nm; and linear gradient program, up to 65 min. The method was developed using an analytical quality by design approach. A systematic flow chart shows the evaluation, control, and life cycle management method. As part of method evaluation, risk assessment was conducted. The method has been validated per current guidelines of the International Conference on Harmonization. The recovery study and linearity ranges were established from the limit of quantification to 150% optimal concentrations. The recovery was found to be between 95.5 and 102.5%, and linearity (r2) was 0.9998–0.9999 for all the identified impurities. The method precision results were achieved below 10% of relative standard deviation. Forced degradation studies were performed under chemical and physical stress conditions. The compound was sensitive to chemical stress conditions. During the study, the analyte degraded and was converted into the identified degradation impurities, and its molecular mass was found using the LC–MS technique.
Unusual complication after augmentation genioplasty: Odontogenic infection requiring implant removal
Authors: Hassanzadeh Tania , Lee Arnold S. 
Published: August 2022

AbstractAugmentation genioplasty is a common surgical procedure with extremely low infection rates. We present the case of a healthy middle‐aged woman who experienced years of chronic infection after chin implantation due to an exposed mandibular canine root, which is exceedingly rare. Awareness of this potential complication may reduce patient morbidity.
Pure small cell neuroendocrine carcinoma of urinary bladder: A case report
Authors: Eshraghi Abbas , Riyahi Mohammad Mehdi , Ghaderi Afshin , Fatemi Maedeh Alsadat , Eshraghi Azhar , Fazilat‐Panah Danial 
Published: August 2022

AbstractSmall cell neuroendocrine carcinoma of the bladder is rare. We report a case of small cell carcinoma of the bladder with extensive regional lymph node metastases who underwent radical cystoprostatectomy and subsequent adjuvant systemic chemotherapy and chemoradiotherapy.
Protein S gene mutation c.946C > T (p.R316C) contributed to ischemic stroke in a man with von Willebrand disease type 3 caused by two novel VWF gene mutations, c.2328delT (p.A778Lfs* 23) and c.6521G > T (p.C2174F)
Authors: Hua Baolai , Yan Xiaobo , He Bin , Shen Lianjun , Poon Man‐Chiu 
Published: August 2022

AbstractThe risk factors for a family with VWD presenting with an ischemic stroke (IS) were explored. FVIII activity (FVIII:C), VWF antigen (VWF:Ag), and protein S activity were measured. Next generation sequencing (NGS) was performed targeting F8, F9, VWF, PROC, and PROS1. Sanger sequencing validation was performed on family members. The proband and his sister both had low FVIII:C (1 IU/dL) and VWF:Ag (3 IU/dL) levels, confirming the diagnosis of type 3 VWD. His father had nearly normal levels of FVIII:C (58 IU/dL) and VWF:Ag (57 IU/dL). His daughter had type 1 VWD with decreased FVIII:C (46 IU/dL) and VWF:Ag (19 IU/dL). NGS identified a heterozygous VWF c.2328delT (p.A778Lfs*23) frame shift mutation only in the proband and his sister. Another VWF missense mutation, c.6521G > T (p.C2174F), was found heterozygous in all members studied. A PROS1 mutation, c.946C > T (p.R316C), previously reported to relate to ischemic stroke, was found heterozygous in the patient, his father, and his daughter. Only the proband and daughter have a slightly decreased plasma protein S level. This may be the first case with type 3 VWD with severe VWF/FVIII deficiency presented with ischemic stroke contributed to by a protein S defect.