bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic effects of estradiol versus testosterone in complete androgen insensitivity syndrome
Authors: Auer Matthias K. , Birnbaum Wiebke , Hartmann Michaela F. , Holterhus Paul-Martin , Kulle Alexandra , Lux Anke , Marshall Luise , Rall Katarina , Richter-Unruh Annette , Werner Ralf , Wudy Stefan A. , Hiort Olaf 
Published: March 2022

AbstractPurposeTo study differences in metabolic outcomes between testosterone and estradiol replacement in probands with complete androgen insensitivity syndrome (CAIS).MethodsIn this multicentre, double-blind, randomized crossover trial, 26 women with CAIS were included of whom 17 completed the study. After a two-months run in phase with estradiol, probands either received transdermal estradiol followed by crossover to transdermal testosterone or vice versa. After six months, differences in lipids, fasting glucose, insulin, hematocrit, liver parameters and blood pressure between the treatment phases were investigated.ResultsLinear mixed models adjusted for period and sequence did not reveal major group differences according to treatment for the investigated outcomes. In each treatment group, there were however significant uniform changes in BMI and cholesterol. BMI increased significantly, following six months of estradiol ( + 2.7%;p = 0.036) as well as testosterone treatment ( + 2.8%;p = 0.036). There was also a significant increase in total ( + 10.4%;p = 0.001) and LDL-cholesterol ( + 29.2%;p = 0.049) and a decrease in HDL-cholesterol (−15.8%;p < 0.001) following six months of estradiol as well as six months of testosterone treatment (total cholesterol: + 14.6%;p = 0.008; LDL-cholesterol: + 39.1%;p = 0.005, HDL-cholesterol: −15.8%;p = 0.004). Other parameters remained unchanged.ConclusionTransdermal estradiol as well as testosterone treatment in women with CAIS results in worsening in lipid profiles. Given the relatively small sample size, subtle group differences in other metabolic parameters may have remained undetected.
Fatal Ogilvie’s syndrome after hip surgery and review of the literature
Authors: Aguiar Diego , Fracasso Tony , Lardi Christelle 
Published: March 2022

AbstractOgilvie’s syndrome refers to a massive dilation of the colon without mechanical obstruction. Although this syndrome is well-known in the clinical literature and may sometimes be encountered as a complication of abdominal, pelvic, or hip surgery, it has only been reported sporadically in the forensic literature. We present the case of a forensic autopsy carried out on a patient whose death was related to cecal necrosis with acute peritonitis due to Ogilvie’s syndrome following hip surgery. This diagnosis was based on clinical data, post-mortem imagery, autopsy findings, histological analysis, post-mortem chemistry, and microbiological analysis. A review of the literature and possible physiopathology of this disease are performed, while focusing on medico-legal perspectives.
6-Hydroxydopamine Induces Neurodegeneration in Terminally Differentiated SH-SY5Y Neuroblastoma Cells via Enrichment of the Nucleosomal Degradation Pathway: a Global Proteomics Approach
Authors: Magalingam Kasthuri Bai , Somanath Sushela Devi , Ramdas Premdass , Haleagrahara Nagaraja , Radhakrishnan Ammu Kutty 
Published: March 2022

AbstractThe SH-SY5Y human neuroblastoma cells have been used for decades as a cell-based model of dopaminergic neurons to explore the underlying science of cellular and molecular mechanisms of neurodegeneration in Parkinson’s disease (PD). However, data revealing the protein expression changes in 6-OHDA induced cytotoxicity in differentiated SH-SY5Y cells remain void. Therefore, we investigated the differentially regulated proteins expressed in terminally differentiated SH-SY5Y cells (differ-SH-SY5Y neural cells) exposed to 6-hydroxydopamine (6-OHDA) using the LC–MS/MS technology and construed the data using the online bioinformatics databases such as PANTHER, STRING, and KEGG. Our studies demonstrated that the neuronal development in differ-SH-SY5Y neural cells was indicated by the overexpression of proteins responsible for neurite formations such as calnexin (CANX) and calreticulin (CALR) besides significant downregulation of ribosomal proteins. The enrichment of the KEGG ribosome pathway was detected with significant downregulation (p < 0.05) of all the 21 ribosomal proteins in differ-SH-SY5Y neural cells compared with undifferentiated cells. Whereas in the PD model, the pathological changes induced by 6-OHDA were indicated by the presence of unfolded and misfolded proteins, which triggered the response of 10 kDa heat shock proteins (HSP), namely HSPE1 and HSPA9. Moreover, the 6-OHDA-induced neurodegeneration in differ-SH-SY5Y neural cells also upregulated the voltage-dependent anion-selective channel protein 1 (VDAC1) protein and enriched the KEGG systemic lupus erythematosus (SLE) pathway that was regulated by 17 histone proteins (p < 0.05) in differ-SH-SY5Y neural cells. These results suggest that the nucleosomal degradation pathway may have regulated the 6-OHDA induced neurodegeneration in PD cell-based model, which is reflected by increased apoptosis and histone release in differ-SH-SY5Y neural cells.
SEOM-GEINO clinical guideline of systemic therapy and management of brain central nervous system metastases (2021)
Authors: Martínez-García María , Servitja Tormo Sonia , Vilariño Quintela Noelia , Arance Fernández Ana , Berrocal Jaime Alfonso , Cantos Sánchez de Ibargüen Blanca , Del Barco Berrón Sonia , García Campelo Rosario , Gironés Sarrió Regina , Manuel Sepúlveda-Sánchez Juan 
Published: March 2022

AbstractCentral nervous system (CNS) dissemination is a severe complication in cancer and a leading cause of cancer-related mortality. Brain metastases (BMs) are the most common types of malignant intracranial tumors and are reported in approximately 25% of patients with metastatic cancers. The recent increase in incidence of BMs is due to several factors including better diagnostic assessments and the development of improved systemic therapies that have lower activity on the CNS. However, newer systemic therapies are being developed that can cross the blood–brain barrier giving us additional tools to treat BMs. The guidelines presented here focus on the efficacy of new targeted systemic therapies and immunotherapies on CNS BMs from breast, melanoma, and lung cancers.
Low-Cost 3D-Printed Reactionware for the Determination of Fatty Acid Content in Edible Oils using a Base-Catalyzed Transesterification Method in Continuous Flow
Authors: du Preez A. , Meijboom R. , Smit E. 
Published: March 2022

AbstractA low-cost flow system was designed, manufactured, and tested to perform automated base-catalyzed transesterification of triacylglycerols to determine the fatty acid content in edible oils. In combination with traditional gas chromatographic analysis (GC-FID), this approach provides a semi-automated process that requires minimal manual intervention. The main flow system components, namely syringe pumps, connectors (i.e., flangeless fittings), and reactors, were manufactured using 3D-printing technology, specifically fused deposition modeling (FDM). By fine-tuning 3D-printer settings, high-quality leak-tight fittings with standard threading were manufactured in polypropylene (PP), which reduced the overall cost of the flow system significantly. Due to the enhanced reactivity in flow, lower catalyst concentrations (≤ 1.5 wt.%) were needed compared to traditional batch reactions (5 wt.%). The suitability of the automated flow method was determined by comparing results with the certified fatty acid content in sunflower seed oil from Helianthus annuus. Acceptable levels of accuracy (relative errors < 5%) and precision (RSD values ≤ 0.02%) were achieved. The mostly 3D-printed flow system was successfully used to determine the fatty acid content of sunflower and other commercial edible oils, namely avocado oil, canola oil, extra virgin olive oil, and a canola and olive oil blend. Linoleic acid (C18:2) was the major component in sunflower oil, whereas all other oils consisted mainly of oleic acid (C18:1). The fatty acid content of the edible oils was comparable to certified and literature values.
Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Model
Authors: Faid Amna H. , Shouman Samia A. , Thabet Nadia A. , Badr Yehia A. , Sliem Mahmoud A. 
Published: March 2022

Abstract
Purpose
We tend to evaluated a method for loading 6Mercaptopurine (6MP) on green synthesized hybrid chitosan gold nanoparticles (AuNPs) forming 6MP-AuNPs nanocomposite for the first time in combinatorial chemo-photothermal therapy.

Methods
The AuNPs were synthesized using chitosan as a reducing and capping agent. Different concentrations of 6MP were mixed AuNPs. Cells were incubated with 6MP and 6MP loaded AuNPs for 48 h and then exposed to laser.

Results
AuNPs and 6MP-AuNPs nanocomposite have small sizes of 18 ± 4 and 25 ± 5 nm and exhibit high stability with Zeta potential of 55.9 ± 6.3 and 57 ± 4 mV. 6MP-AuNPs nanocomposite irradiated with Diode Pumped Solid State (DPSS) laser showed a maximum inhibition in cell viability reaching 63% at 1.25 µM.

Conclusions
A hybrid chitosan gold nanoparticle is a powerful anti-cancer drug carrier as well as photothermal agent in combinatorial chemo-photothermal therapy.
A set of nuclear SNP loci derived from single sample double digest RAD and from pool sequencing for large-scale genetic studies in the European beech Fagus sylvatica
Authors: Blanc-Jolivet Celine , Mader Malte , Liesebach Heike , Kersten Birgit , Degen Bernd 
Published: March 2022

AbstractThe large-scale spatial genetic structure of European beech, Fagus sylvatica, has been until now poorly studied. We conducted double digest RAD sequencing (ddRADseq) on 54 beech individuals stemming from 36 provenances to discover spatially informative nuclear SNP loci. In addition, two pools derived from 14 early and 14 late flushing individuals each were sequenced with Illumina HiSeq. From an initial amount of 5,464 loci detected by ddRADseq, we selected 559 informative loci. Further 27 additional loci showing significant allelic differences among early and late flushing individuals could be identified after a genotyping on 95 test individuals. The final selection of 578 loci was submitted to probe design for targeted genotyping by sequencing, which yielded 543 loci. The new set of SNP loci should be, after validation on a larger sample size, useful for large-scale genetic studies in this economically-important species.
Petro-Mineralogical and Geochemical Evaluation of Glauconitic Rocks of the Ukra Member (Bhuj Formation), Kutch Basin, India
Authors: Shekhar Saurabh , Kumari V. , Sinha S. , Mishra D. , Agrawal A. , Sahu K. K. 
Published: March 2022

AbstractGlauconites occurring within the Ukra Member of Kutch Basin have remained unexplored in terms of their economic significance. The present study aimed to present a detailed physicochemical characterization of glauconite occurring in the siliciclastic rocks of Guneri and Umarsar area of the Kutch district, Gujarat, India to explore their economic potential. The study involved an integrated petrographical, mineralogical, and geochemical investigation of glauconitic rocks to highlight the occurrence, nature, and maturity of glauconite. The characterization was carried out using X-ray diffraction (XRD), X-ray fluorescence (XRF), and electron probe microanalysis (EPMA) combined with energy dispersive X-ray (EDX), Field emission gun scanning electron microscopy (FEG-SEM), Fourier-transform infrared spectroscopy (FTIR), and inductively coupled plasma mass spectroscopy (ICP-MS). Petrographic and bulk XRD analysis revealed that the glauconite occurs as green pellets constituting ~30 and 40% of the glauconitic sandstone and shale, respectively. Whole-rock analysis showed that the value of K2O varies considerably from 3.93 wt.% (sandstone) to 5.63 wt.% (shale). Mineral chemistry indicated the distinctive chemical composition of glauconite pellets containing 7.4–8.4 wt.% of K2O. The parameters, such as the distance between the (001) and (020) peaks and the large K2O content (~8 wt.%) of the glauconite fraction reflect an evolved to highly evolved stage of maturation. The morphological and spectral signatures further support the high degree of maturation in glauconites. Trace-element analysis implied that the glauconitic sandstone and shale contain elements such as Zn, Mn, Cu, Co, Mo, and Ni, which serve as essential micronutrients for plants. These data sets collectively constitute part of a preliminary study which is prerequisite to beneficiation, but further evaluation of its potential as a potash fertilizer also is needed.
Recombination and Novelty in Neuroevolution: A Visual Analysis
Authors: Sarti Stefano , Adair Jason , Ochoa Gabriela 
Published: March 2022

AbstractNeuroevolution has re-emerged as an active topic in the last few years. However, there is a lack of accessible tools to analyse, contrast and visualise the behaviour of neuroevolution systems. A variety of search strategies have been proposed such as Novelty search and Quality-Diversity search, but their impact on the evolutionary dynamics is not well understood. We propose using a data-driven, graph-based model, search trajectory networks (STNs) to analyse, visualise and directly contrast the behaviour of different neuroevolution search methods. Our analysis uses NEAT for solving maze problems with two search strategies: novelty-based and fitness-based, and including and excluding the crossover operator. We model and visualise the trajectories, contrasting and illuminating the behaviour of the studied neuroevolution variants. Our results confirm the advantages of novelty search in this setting, but challenge the usefulness of recombination.
Localized Waves for the Coupled Mixed Derivative Nonlinear Schrödinger Equation in a Birefringent Optical Fiber
Authors: Song N. , Lei Y. X. , Zhang Y. F. , Zhang W. 
Published: March 2022

AbstractIn this paper, the higher-order localized waves for the coupled mixed derivative nonlinear Schrödinger equation are investigated using generalized Darboux transformation. On the basis of seed solutions and a Lax pair, the first- and second-order localized wave solutions are derived from the Nth-order iteration formulas of generalized Darboux transformation. Then, the dynamics of the localized waves are analyzed and displayed via numerical simulation. It is found that the second-order rouge wave split into three first-order rogue waves due to the influence of the separation function. In addition, a series of novel dynamic evolution plots exhibit that rogue waves coexist with dark-bright solitons and breathers.
PHISDetector: A Tool to Detect Diverse In Silico Phage–Host Interaction Signals for Virome Studies
Authors: Zhou Fengxia , Gan Rui , Zhang Fan , Ren Chunyan , Yu Ling , Si Yu , Huang Zhiwei 
Published: March 2022

Abstract
Phage–microbe interactions are appealing systems to study coevolution, and have also been increasingly emphasized due to their roles in human health, disease, and the development of novel therapeutics. Phage–microbe interactions leave diverse signals in bacterial and phage genomic sequences, defined as phage–host interaction signals (PHISs), which include clustered regularly interspaced short palindromic repeats (CRISPR) targeting, prophage, and protein–protein interaction signals. In the present study, we developed a novel tool phage–host interaction signal detector (PHISDetector) to predict phage–host interactions by detecting and integrating diverse in silico PHISs, and scoring the probability of phage–host interactions using machine learning models based on PHIS features. We evaluated the performance of PHISDetector on multiple benchmark datasets and application cases. When tested on a dataset of 758 annotated phage–host pairs, PHISDetector yields the prediction accuracies of 0.51 and 0.73 at the species and genus levels, respectively, outperforming other phage–host prediction tools. When applied to on 125,842 metagenomic viral contigs (mVCs) derived from 3042 geographically diverse samples, a detection rate of 54.54% could be achieved. Furthermore, PHISDetector could predict infecting phages for 85.6% of 368 multidrug-resistant (MDR) bacteria and 30% of 454 human gut bacteria obtained from the National Institutes of Health (NIH) Human Microbiome Project (HMP). The PHISDetector can be run either as a web server (http://www.microbiome-bigdata.com/PHISDetector/) for general users to study individual inputs or as a stand-alone version (https://github.com/HIT-ImmunologyLab/PHISDetector) to process massive phage contigs from virome studies.
A rapidly retreating, marine-terminating glacier's modeled response to perturbations in basal traction
Authors: Downs Jacob , Johnson Jesse V. 
Published: March 2022

AbstractUpernavik Isstrøm, a marine glacier undergoing rapid retreat, is simulated by forcing a numerical model with ocean-driven melt. A review of processes driving retreat led us to hypothesize that a glacier undergoing rapid retreat may be less sensitive to perturbations in the balance of forces than a glacier that is undergoing moderate changes or a glacier in steady state. Numerical experiments suggest this is not the case, and that a system in rapid retreat is as sensitive to basal traction perturbations as a system that is near to steady state. This result is important when considering other glacier systems experiencing marine-forced retreat. While the ice–ocean interface is of primary importance, additional perturbations from meltwater-forced decoupling of the glacier from its bed continue to feature in glacier dynamics.
AESCHYLUS, EUMENIDES 522–5
Authors: Morosi Francesco , Paduano Guido 
Published: March 2022

AbstractEumenides 517–25 contains a centrepiece of Aeschylean ideology—the role of punishment and fear in the ruling of the city. However, the text is vexed by serious issues at lines 522–5. This paper reassesses the main problems, reviews the most influential emendations, and puts forward a new hypothesis. It argues in favour of circumscribing the corruption, offering a new interpretation that permits retention of parts of the text that most editors have deemed impossible to restore.
A Tale of Two Coffee Colonies: Environment and Slavery in Suriname and Saint-Domingue, ca. 1750–1790
Authors: de Bivar Marquese Rafael 
Published: March 2022

AbstractIn the second half of the eighteenth century, European metropolitan powers succeeded in overcoming the dominance that Yemen had hitherto exercised over the world coffee supply. Two colonies of the New World stood out in this transformation, both employing African slave labor on a large scale: Suriname, owned by the Dutch, and Saint-Domingue, the main French colony in the Caribbean. However, Suriname’s growth was short-lived, and it was soon surpassed by the productive leap of Saint-Domingue. The article explores the divergent trajectories of these two colonies, focusing on the environmental conditions of the operation of coffee plantations. Rather than taking the specific combinations of land, labor, capital, and political power as an independent and locally determined set, the article examines how the coffee trajectories of Suriname and Saint-Domingue were mutually formative through the specific evolving relationships that each space had within the world-system.
Colonial Knowledge Economy: Handloom Weavers in Early Twentieth-Century United Provinces, India
Authors: Rai Santosh Kumar 
Published: March 2022

AbstractIn existing historiography, the modernity discourse presents modern knowledge as being more economically efficient and technologically advanced compared to traditional skills. This theoretical lens has introduced a hierarchy of production and restructured the meaning of work and division of labour within the profession of weaving. Historically, the contexts of both the modern textile industry and traditional handloom weaving were interrelated in terms of technology and skills, but they have become increasingly segregated over the last two centuries. This article suggests an apparent distinction between “modernization” as a historical process and “modernity” as a condition. Analysis of the policies and prejudices of the colonial state explains the dynamics between producers, products, and techniques in the handloom textile sector of the United Provinces during the early twentieth century, as well as the impact of government policies, nationalist ideas, and global processes on the sector. Studying these interactions allows us to explore localized nuances pertaining to knowledge and skill that have often been ignored in historiography due to preconceived cultural, political, and institutional compartmentalization of craft communities.
Effectiveness of psychological interventions in preventing postpartum depression in non-depressed women: a systematic review and meta-analysis of randomized controlled trials
Authors: Martín-Gómez Carmen , Moreno-Peral Patricia , Bellón Juan A. , Conejo-Cerón Sonia , Campos-Paino Henar , Gómez-Gómez Irene , Rigabert Alina , Benítez Isabel , Motrico Emma 
Published: March 2022

AbstractPostpartum depression (PPD) is one of the most common disorders following childbirth. This systematic review and meta-analysis (SR/MA) aimed to assess the effectiveness of psychological interventions in preventing PPD in non-depressed women. PRISMA guidelines were followed. MEDLINE (Ovid and PubMed), PsycINFO, Web of Science, Scopus, CINAHL, CENTRAL, OpenGrey, Australian New Zealand Clinical Trial Registry and clinicaltrial.gov were searched. Randomized controlled trials (RCTs) conducted with pregnant or postpartum (up to 12 months) women who were non-depressed at baseline were selected. The outcomes were the incidence of PPD and/or the reduction of postpartum depressive symptoms. The standardized mean difference (SMD) using random-effect models was calculated. Sensitivity, sub-group and meta-regression analyses were performed. 17 RCTs were included in the SR and 15 in the MA, representing 4958 participants from four continents. The pooled SMD was −0.175 [95% confidence interval (CI) −0.266 to −0.083;p< 0.001] and sensitivity analyses confirmed the robustness of this result. Heterogeneity was low (I2 = 21.20%) and was fully explained by a meta-regression model including one variable (previous deliveries). The meta-regression model and MA stratified by previous deliveries indicated that interventions focused on primiparous women are more effective. There was no evidence of publication bias. Few RCTs had an overall low risk of bias. According to GRADE, the quality of evidence was moderate. Psychological interventions have very little effectiveness in preventing PPD in non-depressed women, although this effectiveness is greater in interventions focused on primiparous women. Further RCTs with a low risk of bias and more effective interventions are needed.