bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro Antioxidant Potential and In vivo Analgesic and
Anti-Inflammatory Activities of Moroccan Equisetum ramosissimum
Authors: Larhsini Mustapha , Sissi Saida , Dra Loubna Ait , Ouhaddou Soukaina , Ahmed Ouhammou , Markouk Mohammed 
Published: May 2022

Background:
Equisetum ramosissimum is a pteridophyte plant used in Moroccan traditional
medicine for its diuretic and antidiabetic properties. The species is known to reduce blood
cholesterol levels and is given in cases of gonorrhea.

Objective:
The present work aims to explore the potential use of the crude butanolic (BE) and methanolic
(ME) extracts of E. ramosissimum in the management of pain, inflammation and oxidative
stress, and their chemical characterization.

Methods:
The phytochemical investigation of E. ramosissimum was initially done by colorimetric
methods, followed by High Performance Liquid Chromatography coupled with Mass Spectroscopy
(HPLC-MS). Its antioxidant activity was evaluated using radical scavenging activity in 2,2-
diphenyl-1-picrylhydrazyl radical (DPPH), reducing power and β-carotene/linoleic acid bleaching
assays. The analgesic activity was evaluated by acetic acid in mice and hot-plate-test in rat models.
Rate paw edema and ear edema were used as anti-inflammatory models.

Results:
The chemical quantification revealed appreciable levels of phenolic compounds. The results
of HPLC-UV and HPLC-MS highlighted the presence of kaempferol3-O-sophoroside7-Oglucoside,
kaempferol3,7-O-diglucoside, vanillin, ferulic acid and tannic acid. The maximum IC50
was obtained for BE by DPPH test (0.064±0.0004mg/mL). BE exhibited an interesting antinociceptive
effect; inhibition of writhes, 3.83±0.48 at 600mg/kg, increased the latency period on the hotplate-
test, i.e., 14.98S±0.57S at 400mg/kg after 120min. Furthermore, the results reported a significant
inhibition of rate-paw edema and ear edema for both extracts at a dose of 400mg/kg.

Conclusion:
BE and ME of E. ramosissimum were found to contain a significant amount of flavonoids,
especially derivatives of kaempferol, which can explain the interesting effectiveness properties.
Possible applications in the food and pharmaceutical industries are suggested.
Diet and miRNA: Epigenetic Regulator or a New Class of Supplements?
Authors: Cannataro Roberto , Cione Erika 
Published: May 2022

Abstract:
It is well recognized that diet components are important genomic regulators considering
that food intake influences cytokines such as leptin, ghrelin, adiponectin, and NPY, which regulate
gene expression in response to different nutritional programs, particularly regarding the caloric balance.
However, the single nutrients, both the macro-nutrients, the fatty acids, and above all the micronutrients,
show an essential capacity also for epigenetic regulation; in this sense, vitamins and
their derivatives polyphenols are the main actors.
Acyclic Polyorganochalcogenoethers and their Functional Activities: Synthesis of Sterically Encumbered Hexakis(alkylchalcogenomethyl)benzenes [(RECH2)6C6] [E=S or Se] and their Potential as Selective Ionophores for Hg2+Ions
Authors: Prabhu Nallamuthu , Jyoti  , Kumari Renu , Singh Jai Deo , Butcher Raymond J. 
Published: May 2022

Introduction:An efficient synthesis of hexakis(alkylthio/selenomethyl)benzenes [(RSCH2)6C6 and (RSeCH2)6C6] (1-14) (where, R= nPr, iPr, nBu, iBu, sBu, tBu, nPent, iPent, and 2-Methyl-1-butyl) by the reaction of hexakis(bromomethyl)benzene with alkylthio or alkylseleno (RS-/RSe-) anions are demonstrated.Methods:They have been characterized by physicochemical and spectroscopic methods including single crystal X-ray crystallography. The balances between multiple [C(sp3)-H…S] or [C(sp3)-H…Se] intramolecular interactions in these species appear to decide their stability. Preliminary spectroscopic (UV-vis. and fluorescence) data on the behavior of alkylchalcogeno substituted hexa-benzenes in solution revealed their potential as ion-sensing species and function as highly selective ionophores for Ag+ and Hg2+ ions recognition.Results:In situ, (Hg-S) and (Hg-Se) bond formation on interaction with the chosen hexa-species (2 and 10) and Hg2+ cation revealed a unique ‘turn-off’ or ‘turn-on’ emissive behavior and these function act as reporting fluorescent tool for Hg2+ quantification without use of any external fluorophore.Conclusion:The present study describes an efficient and simple route for the synthesis of sterically encumbered poly-alkylthio/seleno benzenes in high purity and good yields.
Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting Among Civil Servants With Overweight and Obesity: Study Protocol for a Nonrandomized Controlled Trial
Authors: Abdullah Shazana Rifham , Azizul Nur Hayati , Wan Mohd Zin Ruziana Mona , Sulaiman Nur Suffia , Mustafa Khalid Norhayati , Mohd Salim Mullahi Jahn Roshan Jahn , Khalil Muhamad Khairul Nazrin , Abu Seman Norhashimah , Zainal Abidin Nur Azlin , Ali Azizan , Tan You Zhuan , Omar Azahadi , Johari Mohammad Zabri , Abdul Aziz Nur Shahida , Baharudin Azli , Seman Zamtira , Ibrahim Wong Norazizah , Md Rasip Mona Lisa , Yusof Hayati Mohd , Md Noh Mohd Fairulnizal 
Published: May 2022

Background
Overweight and obesity among adults are a growing global public health threat and an essential risk factor for various noncommunicable diseases. Although intermittent fasting is a generally new dietary approach to weight management that has been increasingly practiced worldwide, the effectiveness of 2 days per week dry fasting remains unclear.

Objective
The Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting study aims to determine the cardiometabolic, anthropometric, dietary intake, and quality of life changes among civil servants with overweight and obesity, following combined intermittent fasting and healthy plate (IFHP) and healthy plate (HP) and explore the participants’ experiences.

Methods
We designed a mixed methods quasi-experimental study to evaluate the effectiveness of the IFHP and HP methods among adults with overweight and obesity. A total of 177 participants were recruited for this study, of which 91 (51.4%) were allocated to the IFHP group and 86 (48.6%) to the HP group. The intervention comprised 2 phases: supervised (12 weeks) and unsupervised (12 weeks). Data collection was conducted at baseline, after the supervised phase (week 12), and after the unsupervised phase (week 24). Serum and whole blood samples were collected from each participant for analysis. Data on sociodemographic factors, quality of life, physical activity, and dietary intake were also obtained using questionnaires during data collection.

Results
Most of the participants were female (147/177, 83.1%) and Malay (141/177, 79.7%). The expected outcomes of this study are changes in body weight, body composition, quality of life, physical activity, dietary intake, and cardiometabolic parameters such as fasting blood glucose, 2-hour postprandial blood glucose, hemoglobin A1c, fasting insulin, and lipid profile.

Conclusions
The Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting study is a mixed methods study to evaluate the effectiveness of combined IFHP and HP interventions on cardiometabolic and anthropometric parameters and explore participants’ experiences throughout the study.

Trial Registration
ClinicalTrials.gov NCT05034653; https://clinicaltrials.gov/ct2/show/NCT05034653

International Registered Report Identifier (IRRID)
RR1-10.2196/33801
EZETIMIBE NANOSTRUCTURED LIPID CARRIERS (NLCs): A NEW TECHNIQUE TO OVERCOME THE LIMITATIONS OF ORAL ADMINISTRATION
Authors: M. KAOUD RASHAD , HEIKAL EMAN J. , GAD SHADEED 
Published: May 2022

Objective: Ezetimibe (EMB) is a commonly used lipid-lowering medication that lowers cholesterol and triglycerides. Because of its lower water solubility and hepatic metabolism, it necessitates the formulation of drug delivery systems that are capable of improving solubility and avoiding hepatic effect.
Methods: Ezetimibe nanostructured lipid carriers (EMB-NLCs) were formulated and examined. They were formulated through emulsification with a high homogenization speed and ultrasonication (The method and evaluation parameters have been mentioned under method section in Formulation of EMB-NLCs paragraph).
Results: The formulated NLCs have exhibited particle size (P. S.) between 163.6±7.20 and 866.66±18.65 nm and the zeta potential (Z. P.) values have ranged between-24±1.25 and-35±0.25 mV. Besides, they exhibited higher EE% than 77 percent and the drug encapsulated in lipid matrix was in amorphous state. Pharmacokinetics of optimized formula (F1; composed of 2% w/w Gelucire® 43/01, 8% w/w Miglyol® 812 N, 0.5% w/w lecithin and 2% w/w Poloxmer® 188) have exhibited 2.63-and 2.33-fold increase in oral bioavailability in comparison with EMB suspension and marketing product (Ezetrol® 10 mg tablet), respectively.
Conclusion: These studies have demonstrated that, NLCs are superior for enhancing in vivo behavior and oral bioavailability of EMB.
Cost–effectiveness of concurrent radiation with cetuximab or chemotherapy in older patients with oropharyngeal cancer
Authors: Albarmawi Husam , Cullen Kevin J , Mehra Ranee , Onukwugha Eberechukwu , Goloubeva Olga 
Published: May 2022

Aim:
To assess the cost–effectiveness of definitive therapies for nonmetastatic oropharyngeal cancer (OPC).
Materials & methods:
Using the Surveillance, Epidemiology and End Results-Medicare dataset, patients diagnosed between 2000 and 2011 were identified. The cost–effectiveness of chemoradiation (CRT) versus radiotherapy (RT), cetuximab plus RT (cetuximab-RT) versus RT and cetuximab-RT versus CRT were estimated.
Results:
The incremental cost–effectiveness ratio for CRT compared with RT from 2000 to 2005 was US$56,650 (95% CI: US$4,522–$288,688) per additional year of survival. CRT was dominated by RT from 2006 to 2011. Cetuximab-RT was dominated by RT and CRT.
Conclusion:
CRT had a favorable value from 2000 to 2005 but was dominated by RT from 2006 to 2011. The value of cetuximab-RT compared with RT/CRT was not favorable with similar/inferior survival and substantial incremental costs.
Analisa Fourier Broadband Forecasting Jaringan Telekomunikasi di Indonesia dalam menyambut Visi Indonesia 2045
Authors: Ramadona Suci , Ahdan Syaiful , Rahayu Maya 
Published: May 2022

Berdasarkan data APJII (Asosiasi Penyelenggara Jasa Internet Indonesia di tahun 2020, terdapat 73.7% dari populasi Indonesia telah menggunakan jaringan broadband. Pertumbuhan jumlah pengguna layanan broadband ini akan mempengaruhi visi Indonesia Emas 2045. Dimana di dalam visi 2045 tersebut dipaparkan bahwa aspek TIK (Teknologi Informasi Komunikasi) akan terintegrasi di segala bidang, terutama aspek ekonomi dan pemeritahan. Demi tercapainya Indonesia Emas 2045 dan agar semakin baiknya tingkat kepuasan pelanggan, maka pemerintah dan penyedia jasa dirasa perlu menyediakan layanan yang mumpuni. Research ini menyajikan jumlah pengguna jaringan mobile dan fixed broadband, serta harga paket data di Indonesia dalam bentuk Forcasting Analisa Fourier hingga di tahun 2045. Dimana metodologi yang digunakan adalah dengan mengumpulan data jumlah pengguna 2011-2020 dan tren harga paket dari tahun 2008-2020 lalu dilakukannya proses forcasting menggunakan Analisa Fourier, kemudian data validasi dilakukan di tahun 2019-2020. Teknik forcasting menggunakan Analisa Fourier dinyatakan cukup baik dengan estimasi error forecasting kurang dari 8%.
Imam Ali Ibn Musa al-Ridha (A. S.)-The Exquisite Sun of Bani Hashim
Authors: Fatima Dr. Syeda Farhat 
Published: May 2022

Ali Ibn Musa al-Rida was the eighth great grandson of Fatima Zehra (daughter of Prophet Mohammad, peace be upon him) and Ali Ibn Abi Talib and he is also the eighth Imam of Shiite believers. He was an embodiment of etiquette, manners and charity and he imparted to us the qualities of a believer. His teachings were ‘How a man should strive to be a believer of Allah (S.w.t)?’He highlighted in his preaching’s the ways to seek the pleasure of Allah (s.w.t) was through piousness, tolerance and persistence in our righteous deeds. He also emphasized us that for a believer to control his/her nafs (psyche)is prominent among his actions. Because of Imam Ali Ridha’s (a. s.) high moral traits and pleasing personality, he (a. s.) was considered the exquisite sun of Bibi Fatima Zehra and the Bani Hashim clan. This paper aims to show that Imam Ali Ibn Musa al-Ridha’s reward from Allah (s.w.t) is complete peace of mind as he stuck to his spiritual values being away from his homeland.
Dilemmas of Women in Shashi Deshpande’s That Long Silence
Authors: P Anusha. , Kavitha Dr.R 
Published: May 2022

The main objective of this paper is to present the problems faced by women in India, especially their position in family and society through the work of Shashi Deshpandes That Long Silence'. According to Indian tradition, wives are always subservient to their husbands and family. And is seen that a women's life is completely controlled either by her family or her husband. Women sacrifice their dreams and desires for the sake of their families. They are not allowed to share their thoughts or opinions on anything, all they can do is accept the decision taken by a man with great silence.
Jaya the protagonist of 'That Long Silence' represents the 90's women in our society. The title of the novel itself refers to the conditions of women in a patriarchal setup. Deshpande’s novel directly deals with the dilemmas of housewives. The novel itself can be said to be an autobiographical novel of Deshpande. Deshpande has mainly focused on the life of middle-class educated women in the late 90s Indian society.
INTERPERSONAL METAPHOR IN R. S. REGIN SILVEST AND MALINI GANAPATHY’S ANTHOLOGY OF COVID-19 POEMS.
Authors: Rezeki Sri . , Saragih Amrin . , Setyasari Winda . 
Published: May 2022

This study investigates Interpersonal Metaphor in R.S. Regin Silvest and Malini Ganapathy’s Anthology of Covid-19 Poems. The objectives of the study are (1) to analyze the kinds of interpersonal metaphor applied in R.S. Regin Silvest and Malini Ganapathy’s Anthology of Covid-19 Poems, (2) to describe how the interpersonal metaphor applied in R.S. Regin Silvest and Malini Ganapathy’s Anthology of Covid-19 Poems, (3) and to explain the reason for the realization of interpersonal metaphor in R.S. Regin Silvest and Malini Ganapathy’s Anthology of Covid-19 Poems. This study conducted qualitative research, and as the result of fifty poems there are thirty five Poems of Covid-19 that indicate as Interpersonal Metaphor. Result revealed that there were sixty-three Interpersonal metaphor found in this study namely, Interpersonal metaphor of Mood were thirty-seven and Interpersonal Metaphor of Modality were twenty-six, Interpersonal Metaphor of Mood applied in the Speech Function, namely, Question in Declarative Mood were 18 (49%), Command in Declarative Mood were 13 (35%), Statement in Interrogative Mood were 5 (13%), Question in Imperative Mood 1 (3%), And Interpersonal Metaphor of Modality applied in kinds of modality namely, Modalization were 14 (54%) and Modulation were 12 (46%). From thirty five poems of Covid-19 which consist of Interpersonal Metaphor, there were four meanings and messages found, Expressing the fear of Covid-19 were 15 (43%), Expressing advice and lesson about Covid-19 11 were (31%), Delivering the spirit and positive energy during Covid-19 Pandemic were 5 were (14%) and Expressing hope for better days were 4 (12%).
Reverse Takotsubo cardiomyopathy after orthotopic liver transplantation. A case report
Authors: Mihalcea Lucian , Sebastian Isac , Simion-Cotorogea Mihail , Klimko Artsiom , Droc Gabriela 
Published: May 2022

Abstract

Introduction
Takotsubo cardiomyopathy is a rare reversible type of heart failure, often precipitated by emotional stress; other risk factors include intracranial bleeding, ischemic stroke, sepsis, major surgery, pheochromocytoma. The clinical, electrical and blood sample analysis features resemble those of a myocardial infarction- however, they occur in the absence of angiographic coronary filling defects.

Case presentation
A 61-year-old male patient, 71 kg, 175 cm, underwent liver transplantation for Child-Pugh B cirrhosis secondary to mixed viral hepatitis (B and D). His medical records revealed mild mitral, aortic, and tricuspid insufficiencies and heart failure with preserved ejection fraction. An initially uneventful perioperative stage was succeeded by cardiogenic shock (cardiac index – 1.2 l/min/ sqm), which the patient developed 24 hours after the intervention. Elevated cardiac markers and ECG abnormalities showing ST-T changes in the V2-V5 leads were additionally noted. Transesophageal echocardiography (TEE) revealed an acute onset reduction in the left ventricular systolic function secondary to basal hypokinesia. No coronary obstruction was detected by percutaneous angiography. The above findings lead to the diagnosis of reverseTakotsubo cardiomyopathy. Further, the patient developed acute kidney injury and liver graft failure, succumbing within 48 hours after the surgical procedure.

Conclusions
We report a rare case of reverse Takotsubo cardiomyopathy in a male patient after orthotopic liver transplant.
Using Machine Learning Techniques to Predict Hospital Admission at the Emergency Department
Authors: Feretzakis Georgios , Karlis George , Loupelis Evangelos , Kalles Dimitris , Chatzikyriakou Rea , Trakas Nikolaos , Karakou Eugenia , Sakagianni Aikaterini , Tzelves Lazaros , Petropoulou Stavroula , Tika Aikaterini , Dalainas Ilias , Kaldis Vasileios 
Published: May 2022

Abstract

Introduction
One of the most important tasks in the Emergency Department (ED) is to promptly identify the patients who will benefit from hospital admission. Machine Learning (ML) techniques show promise as diagnostic aids in healthcare.

Aim of the study
Our objective was to find an algorithm using ML techniques to assist clinical decision-making in the emergency setting.

Material and methods
We assessed the following features seeking to investigate their performance in predicting hospital admission: serum levels of Urea, Creatinine, Lactate Dehydrogenase, Creatine Kinase, C-Reactive Protein, Complete Blood Count with differential, Activated Partial Thromboplastin Time, DDi-mer, International Normalized Ratio, age, gender, triage disposition to ED unit and ambulance utilization. A total of 3,204 ED visits were analyzed.

Results
The proposed algorithms generated models which demonstrated acceptable performance in predicting hospital admission of ED patients. The range of F-measure and ROC Area values of all eight evaluated algorithms were [0.679-0.708] and [0.734-0.774], respectively. The main advantages of this tool include easy access, availability, yes/no result, and low cost. The clinical implications of our approach might facilitate a shift from traditional clinical decision-making to a more sophisticated model.

Conclusions
Developing robust prognostic models with the utilization of common biomarkers is a project that might shape the future of emergency medicine. Our findings warrant confirmation with implementation in pragmatic ED trials.
Early Empirical Anidulafungin Reduces the Prevalence of Invasive Candidiasis in Critically Ill Patients: A Case-control Study
Authors: Hasan Md Jahidul , Neelotpol Sharmind , Rabbani Raihan 
Published: May 2022

Abstract

Introduction
Invasive candidiasis (IC) in critically ill patients is a serious infection with high rate of mortality. As an empirical therapy, like antibiotics, the use of antifungals is not common in intensive care units (ICUs) worldwide. The empirical use of echinocandins including anidulafungin is a recent trend.

Aim of the study
The objective of this study was to assess the impact of empirical anidulafungin in the development of invasive candidiasis in critically ill patients in ICU.

Methods
This retrospective case-control study was conducted on 149 patients with sepsis with/without septic shock and bacterial pneumonia. All the patients were divided into two groups. The ‘control group’ termed as ‘NEAT group’ received no empirical anidulafungin therapy and the ‘treated group’ termed as ‘EAT group’ received empirical anidulafungin therapy in early hospitalization hours.

Results
Seventy-two and 77 patients were divided into the control and the treated group, respectively. Patients in EAT group showed less incidences of IC (5.19%) than that of the NEAT group (29.17%) (p = 0.001). Here, the relative risk (RR) was 0.175 (95% CI, 0.064-0.493) and the risk difference (RD) rate was 24% (95% CI, 12.36%-35.58%). The 30-day all-cause mortality rate in NEAT group was higher (19.44%) than that of in EAT group (10.39%) (p = 0.04). Within the first 10-ICU-day, patients in the EAT group left ICU in higher rate (62.34%) than that in the NEAT group (54.17%).

Conclusion
Early empirical anidulafungin within 6 h of ICU admission reduced the risk of invasive candidiasis, 30-day all-cause mortality rate and increased ICU leaving rate within 10-day of ICU admission in critically ill patients.
کردەی بەڵێنپێدان لە پرۆسەی بانگەشەی هەڵبژاردنەکاندا
Authors: عومەر تەلان محەمەد , ئه‌حمه‌د كه‌لسوم خالید , مەحمود ئازاد ئەحمەد 
Published: May 2022

يشير هذا البحث الموسومة ب: عملية التعهد في مشروع الحملة الانتخابية (انتخابات 2018 ٲنموذجا) ٳلى نظرية العملية اللفظية (الكلامية). ٳن هذا البحث له خصوصية التعهدات الشفهية لرؤساء القوائم في انتخابات برلمان كوردستان، وبهذا تختلف هذه التعهدات مع الحديث الٳعتيادي (الكلام). وهذا البحث يعالج الٲفعال الكلامية لٲوستين وسيرل ضمن النظرية البراكماتيكية، ٳذ تتبوٲ المعالجة عمق العملية الكلامية، متضمنا ملخص حديث رؤساء القوائم الانتخابية. هذا، وترتبط هذه النظرية بعدد الخطوات التي يشجعها المتحدث علی ٲداء الخطاب بأثر مباشر و فعال، كما وتحدد هذه النظرية الحدود بين المتحدث والمستمع، ٳلی جانب ٲن نظرية الكلام نفسها تقسم ٳلی خمسة ٲنواع. يتضمن البحث مقدمة وفصلين، ويختمه بنتائج البحث. فالفصل الاول ٲومٲ ٳلی التفسير بين اللغة و السياسة، وعلاقة اللغة بالسياسة، ٳلی جانب الوقوف علی نظرية العملية اللفظية وتاريخ ظهورها وٲنواعها، والتي ٲقرها ٲوستين علی خمسة ٲنواع: الٳعلام، والوصف، والتعبير عن المشاعر، والٲمر، والعمليات اللفظية ذات الصلة. في حين، صنفها سيرل على النحو الآتي: التمثيل، والٲمر، والرابط، والتعبير، والٳعلام. ٲما الفصل الثاني، فهو فصل تطبيقي، يعالج عملية التعهدات المتعلقة بهذا الخطاب، التي يمكن تنفيذها؛ بغية الحفاظ على العلاقة الاجتماعية بين ٲفراد المجتمع بٲهمية بالغة في فضاء الخطاب التواصلي.
An Empirical Investigation on the Impact of the New Electronic Educational Facilities
Authors: Abdulmajeed Bnar , Mohammed Shirzad , Abdullah Baderkhan , Abdullah Ali 
Published: May 2022

The study is conducted to examine the underlying mechanism through which electronic education influences e-teaching /e-learning. In addition, this paper aims to examine contingent factors in the relationship between electronic educational facilities and e-teaching /e-learning. A total of 161 respondents (university lecturers and staff) were selected, questionnaire was distributed and collected in two methods, manually distribution and electronically. Hypotheses were tested with Correlation’s matrix, t-test, and linear Regression analysis. The result shows that electronic educational facilities have a positive relation with electronic education and e-teaching /e-learning. Moreover, the result indicates that electronic education enhances e-teaching /e-learning if electronic educational facilities are highly efficient. It means that electronic educational facilities have a positive mediator role between electronic education and e-teaching /e-learning. Our findings highlight that the electronic educational facilities bring high-quality education equivalent and higher to the studying at the campus.