bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the origin of different variants associated with familial mediterranean fever by machine-learning
Authors: Adato Orit , Brenner Ronen , Levy Avi , Shinar Yael , Shemer Asaf , Dvir Shalem , Ben-Zvi Ilan , Livneh Avi , Unger Ron , Kivity Shaye 
Published: September 2022

AbstractA growing number of familial Mediterranean fever (FMF) patients in Israel do not have a single country of origin for all four grandparents. We aimed to predict the Mediterranean fever gene (MEFV) variant most likely to be found for an individual FMF patient, by a machine learning approach. This study was conducted at the Sheba Medical Center, a referral center for FMF in Israel. All Jewish referrals included in this study carried an FMF associated variant in MEFV as shown by genetic testing performed between 2001 and 2017. We introduced the term ‘origin score’ to capture the dose and different combinations of the grandparents’ origin. A machine learning approach was used to analyze the data. In a total of 1781 referrals included in this study, the p.Met694Val variant was the most common, and the variants p.Glu148Gln and p.Val726Ala second and third most common, respectively. Of 26 countries of origin analyzed, those that increased the likelihood of a referral to carry specific variants were identified in North Africa for p.Met694Val, Europe for p.Val726Ala, and west Asia for p.Glu148Gln. Fourteen of the studied countries did not show a highly probable variant. Based on our results, it is possible to describe an association between modern day origins of the three most common MEFV variant types and a geographical region. A strong geographic association could arise from positive selection of a specific MEFV variant conferring resistance to endemic infectious agents.
Ultrasonography measurement of glottic transverse diameter and subglottic diameter to predict endotracheal tube size in children: a prospective cohort study
Authors: Deekiatphaiboon Chanya , Oofuvong Maliwan , Karnjanawanichkul Orarat , Siripruekpong Sirikarn , Bussadee Pattamawan 
Published: September 2022

AbstractWe aimed to determine the correlation between mid-glottic transverse diameter/subglottic diameter and outer diameter of endotracheal tube (ETT) by ultrasonography in children. Ninety-five patients aged 1–8 years who underwent general anesthesia were included. Ultrasonography of glottic/subglottic transverse diameter was performed by two investigators after patients were anesthetized and when the train of four showed ≤ 4. The subglottic diameter was measured at the mid cricoid cartilage. The mid-glottic transverse diameter was measured at the mid-point of true vocal fold triangle whereas the distance between arytenoids was considered as the glottic transverse diameter. Linear regression models and correlation coefficients (r) were used to determine the best formula of glottic/subglottic transverse diameter to predict the outer diameter of ETT. The predicted outer diameter of ETT formula for subglottic diameter, mid-glottic transverse diameter, and glottic transverse diameter were 5.7 + (subglotticmm/3) with an r of 0.45, 5.5 + (midglotticmm/2) with an r of 0.47, and 5.7 + (glotticmm/4) with an r of 0.46, respectively. The correlation between subglottic diameter and mid-glottic transverse diameter was 0.50. Subglottic/mid-glottic/glottic transverse diameter formulae had moderate correlations with the outer diameter of ETT. The glottic/mid-glottic transverse diameter can be used alternatively to predict the ETT size.Trial registration: Thai Clinical Trial Registry: TCTR20191022002 Registered 22/10/2019—Prospectively registered, https://www.thaiclinicaltrials.org/# TCTR20191022002.
Hypertension and renal disease programming: focus on the early postnatal period
Authors: Albertoni Borghese Maria Florencia , Oronel Lucas Humberto , Ortiz Maria Del Carmen , Majowicz Mónica Patricia 
Published: September 2022

Abstract
The developmental origin of hypertension and renal disease is a concept highly supported by strong evidence coming from both human and animal studies. During development there are periods in which the organs are more vulnerable to stressors. Such periods of susceptibility are also called ‘sensitive windows of exposure’. It was shown that as earlier an adverse event occurs; the greater are the consequences for health impairment. However, evidence show that the postnatal period is also quite important for hypertension and renal disease programming, especially in rodents because they complete nephrogenesis postnatally, and it is also important during preterm human birth.
Considering that the developing kidney is vulnerable to early-life stressors, renal programming is a key element in the developmental programming of hypertension and renal disease.
The purpose of this review is to highlight the great number of studies, most of them performed in animal models, showing the broad range of stressors involved in hypertension and renal disease programming, with a particular focus on the stressors that occur during the early postnatal period. These stressors mainly include undernutrition or specific nutritional deficits, chronic behavioral stress, exposure to environmental chemicals, and pharmacological treatments that affect some important factors involved in renal physiology.
We also discuss the common molecular mechanisms that are activated by the mentioned stressors and that promote the appearance of these adult diseases, with a brief description on some reprogramming strategies, which is a relatively new and promising field to treat or to prevent these diseases.
Speech-Language Pathology's Role in Management of Orofacial Contractures After a Facial Burn
Authors: Arguello Lori Ann , Kerr Kathleen M. 
Published: September 2022

Purpose:
Care of the burn patient continues to advance and requires a comprehensive interdisciplinary team. With advances in medical sciences, mortality has declined for patients with large total body surface area burns, and this has resulted in the need for more hands-on clinical judgment and skill from the speech-language pathologist working with burn survivors. Patients with a facial burn injury pose a special challenge for intervention by the speech-language pathologist. This population calls upon the therapist to be able to assess and treat the limiting effects of orofacial scarring and contractures, as well as speech, language, voice, cognitive, and swallowing disorders. Traditionally, occupational and physical therapists have managed orofacial contractures in this population with methods such as pressure garments, silicone masks, and oral splints. Research and data on cutaneous functional units have shown that occupational and physical therapists require significant time to address the whole body needs of the burn care patient, calling for increased involvement from all professionals especially in larger total body surface area burns. Microstomia and orofacial contractures are a treatment need for the facial burn population and present a collaborative treatment opportunity for the speech-language pathologist.

Conclusions:
This article will cover the mechanism of a facial burn injury and how it may cause functional impairments that can be directly impacted through early intervention utilizing speech-language pathology services. Best practice in the care of a patient with dermal or full thickness facial burns should include a referral to the speech-language pathologist. There is an opportunity to expand service delivery by the speech-language pathologist in the acute care and outpatient arenas of burn care.
Operation and control of a synch invulnerable master‐slave organised islanded alternating current microgrid
Authors: Ansari Shamsher , Tariq Mohd , Chandel Aseem , Khan Baseem 
Published: September 2022

AbstractMicrogrid (MG) bridges different inverter interfaced distributed energy resources (DERs) to operate and control efficiently within a grid. The multi‐master‐slave control strategy can provide robust control of inverter interfaced DERs in close proximity. The role of master DERs is significant in synchronising the slave DERs and reducing the effect of single unit failure. However, faulty master DERs and master side communication failure can also suddenly affect the synchronisation of the slave DERs. Unfortunately, previous studies on multi‐master‐slave MGs have not addressed this issue. So, in this paper, a synch invulnerable multi‐master‐slave control strategy is proposed by introducing a synch selector with the centralised secondary controller. The synch selector is designed to pick the synchronising references from the first available healthy master units while keeping other masters operational and sending the synchronising references to the slave DERs. It also significantly reduced the dependency on communication lines up to the possible extent. Real‐time simulation results are presented to demonstrate the effectiveness of the proposed control strategy. The presented results show that the unhealthy master units seamlessly can be side‐stepped, and the next possible healthy master unit can be assigned to send reference signals to the slave DERs, hence, resisting synch vulnerability. The observations also show accurate power‐sharing, full utilisation of DERs, and reliable and stable operation of the entire MG.
A multi‐port hybrid circuit breaker integrated with power flow control ability
Authors: Yu Jingqiu , Zhang Zheren , Xu Zheng 
Published: September 2022

AbstractPower flow controllers and DC circuit breakers are compulsory components in a multi‐terminal DC grid with overhead lines. They are both composed of similar power electronic devices and thus can be reasonably combined together to realize cost savings. This paper proposes a multi‐port circuit breaker integrated with a multi‐port power flow controller (M‐PFCHCB). The topology structure, operation principles, control strategy and parameter configuration are illustrated in detail. The main breakers are composed of unidirectional power electronic switches, and the selection branch is based on two diode strings, which can significantly save the investment of the breaker. The proposed M‐PFCHCB is able to deal with the fault isolation and the ultra‐fast disconnector failure with high performance. Besides, the power flow of multiple lines can be simultaneously regulated by the M‐PFCHCB without any external power supply. The internal power balance is achieved by controlling the AC circulating current inside the M‐PFCHCB. The simulations conducted on PSCAD in a five‐terminal DC grid with eight DC lines verify the feasibility of the proposed M‐PFCHCB. The technical and economic analysis performed proves that the proposed M‐PFCHCB can achieve the comprehensive functions of fault isolation and power flow control with low construction cost.
Human elbow flexion behaviour recognition based on posture estimation in complex scenes
Authors: Gong Faming , Li Yunjing , Yuan Xiangbing , Liu Xin , Gao Yating 
Published: September 2022

AbstractAiming at the difficulty of recognising the smoking and making phone calls behaviours of people in the complex background of construction sites, a method of recognising human elbow flexion behaviour based on posture estimation is proposed. The human upper body key points needed are retrained based on AlphaPose to achieve human object localization and key points detection. Then, a mathematical model for human elbow flexion behaviour discrimination (HEFBD model) is proposed based on human key points, as well as locating the region of interest for small object detection and reducing the interference of complex background. A super‐resolution image reconstruction method is used for pre‐processing some blurred images. In addition, YOLOv5s is improved by adding a small object detection layer and integrating a convolutional block attention model to improve the detection performance. The detection precision of this method is improved by 5.6%, and the false detection rate caused by complex background is reduced by 13%, which outperforms other state‐of‐the‐art detection methods and meets the requirement of real‐time performance.
Deprescribing im Alter
Authors: Waltering Isabell 
Published: September 2022

ZusammenfassungÄltere Patienten wenden zumeist mehrere Arzneimittel zur Behandlung ihrer
Erkrankungen an. Auch wenn diese Medikamente zur Therapie von Beschwerden und
Symptomen verordnet werden, so können ihre Nebenwirkungen, speziell
für ältere Patienten mit vielen Arzneimitteln, schädlich
sein. Solche unangemessenen Medikamente sind für 11% der
Krankenhauseinweisungen verantwortlich. Obwohl dieser Umstand bekannt ist, sind
Daten, wie man diese Medikation für diese verletzliche Population
beendet, nur spärlich vorhanden. Forschungsdaten belegen, dass eine
präzise Struktur und sorgfältige Planung für einen
erfolgreichen Deprescribing-Prozess unabdingbar sind, was auch bedeutet,
verschiedene Beteiligte in diesen Prozess miteinzubeziehen, um für
Patienten ein optimales Ergebnis zu erzielen. Bislang existiert keine Vorgabe,
wie Phytopharmaka in diesen Prozess eingebunden werden können. Dieser
Artikel liefert eine Definition für Deprescribing im deutschsprachigen
Raum, eine Beschreibung der strukturierten Vorgehensweise und bietet einen
Ansatz zur Einbeziehung von Phytotherapeutika in den Deprescribing-Prozess.
Phytotherapie auch im Alter gut verträglich – Daten
aus der PhytoVIS-Studie
Authors: Gramlinger Tamara , Kelber Olaf , Kraft Karin 
Published: September 2022

ZusammenfassungPflanzliche Arzneimittel (Phytopharmaka) spielen für die
eigenverantwortliche Behandlung, gerade auch der Älteren, eine
große Rolle und decken dabei ein breit gefächertes
Indikationsgebiet ab. Um Daten zu ihrer Anwendung zu gewinnen, hat die
Kooperation Phytopharmaka die PhytoVIS-Studie initiiert, deren Ergebnis
produktübergreifende und indikationsbezogene pharmakoepidemiologische
Daten von über 20 000 Patienten sind, die ein pflanzliches
Arzneimittel eingenommen haben, darunter 3065 Patienten mit einem Alter von mehr
als 65 Jahren.Deren Auswertung ergab, dass Unterschiede zur in der Studie erfassten
Gesamtpopulation nur bei wenigen Aspekten deutlich wurden. So war der Anteil der
Patienten, die keinerlei Beeinträchtigung durch Nebenwirkungen
empfanden, bei den 66–75-Jährigen mit 91,9% und den
über 75-Jährigen mit 93,8% leicht gegenüber der
Gesamtpopulation mit 91,2% erhöht. Der Anteil chronischer
Erkrankungen und Beschwerden war gegenüber der Gesamtpopulation auf ein
Mehrfaches erhöht, wie z. B. erhöhte Vergesslichkeit
(4,3- bzw. 5,3-fach erhöht) und Arthralgie (2,6- bzw. 3,5-fach
erhöht). Zudem wendeten 48% der 66–75-Jährigen
und 56% der über 75-Jährigen das Arzneimittel
langfristig an, gegenüber 28% in der Gesamtpopulation. Der
Anteil der Komorbiditäten war mit 76,0 bzw. 82,8 vs. 39,8%
(Gesamtpopulation) deutlich höher, ebenso der einer Komedikation. Dabei
gibt die bei den Älteren vergleichbare und teils sogar bessere
Verträglichkeit keinen Hinweis auf eine erhöhte
Wechselwirkungsrate.Phytopharmaka sind daher für eine immer älter werdende
Bevölkerung auch in der Selbstmedikation eine wichtige und sichere
Therapieoption.
Digital Health als Funktionsbereich in Krankenhäusern:
Erfahrungen nach zweijährigem Betrieb der Stabsstelle für
medizinische Prozessentwicklung am Klinikum Darmstadt
Authors: Hoffmann Felix , Khaladj Nawid 
Published: September 2022

ZusammenfassungAm Klinikum Darmstadt wurde früh erkannt, dass die Herausforderungen in
der Weiterentwicklung des Klinikums im Zuge der digitalen Transformation eng mit
der Prozessinfrastruktur im Klinikum und darüber hinaus
verknüpft sind. Um die Herausforderungen im Zusammenhang mit der
Prozessentwicklung auch organisatorisch abzubilden, wurde im Januar 2020 die
Stabsstelle für medizinische Prozessentwicklung eingerichtet. Nach
zweijährigem Betrieb wird nun ein Fazit gezogen, um den Nutzen des
ärztlichen Tätigkeitsfeldes „Prozessentwicklung und
Digitalisierung“ darzustellen, wichtige Erfahrungen zu dokumentieren und
Implikationen für das Krankenhausmanagement und die Aus- und
Weiterbildung daraus abzuleiten.
Visible-Light-Promoted Metal-Free 3-Arylation of 2-Aryl-2H-­indazoles with Triarylsulfonium Salts
Authors: Sun Kai , Yu Bing , Shi Anzai , Xiang Panjie , Wu Yanxuan , Ge Chang , Liu Yan 
Published: September 2022

AbstractAn efficient approach for the photosynthesis of various arylated 2-aryl-2H-indazoles (38 examples) in moderate to good yields (up to 87% yield) under mild conditions was developed by employing 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) as an inexpensive photocatalyst. This protocol features wide substrate scope, good functional group tolerance, and operational simplicity. In addition, the strategy was successfully applied to the late-stage modification of drug molecules, and the meaningful introduction of complex drugs to the skeleton of 2H-Indazole was achieved for the first time.
Recent Advances in Room-Temperature Direct C–H Arylation Methodologies
Authors: Luscombe Christine K. , Yadav Preeti , Velmurugan Nivedha 
Published: September 2022

AbstractIn recent decades, direct C–H arylation has become a preferred tool for biaryl coupling over traditional cross-coupling methods owing to its operationally simple protocol, inherent atom and step economy, and reduced metallic waste. Several elegant methods have been developed that offer the facile transformation of usually inert Csp2–H bonds into Csp2–Csp2 bonds in a single synthetic operation. Despite many merits, a major drawback to this chemistry comes from the low reactivity of aryl C–H bonds, which often mandate harsh reaction conditions compromising sustainability. Hence, developing reaction protocols that require milder conditions has become an important goal in this area of research. This review article comprehensively highlights the synthesis and mechanistic aspects of direct C–H arylation reactions, which proceed at or below room temperature.1	Introduction2	Concepts and Examples2.1	Transition-Metal-Catalyzed Procedures2.1.1	Pd Catalysis2.1.2	Other Metal-Based Procedures2.1.3	Additive-Free Procedures2.2	Direct Arylation Polymerization2.3	Photocatalyzed Procedures2.3.1	Organometallic C–H-Activation-Based Procedures2.3.2	Radical-Addition-Based Procedures2.4	Transition-Metal-Free Procedures2.4.1	Base-Mediated Procedures2.4.2	Iodonium- and Diazonium-Salt-Based Procedures2.5	Electrocatalyzed Procedures3	Summary and Outlook
Effect of Additional Apical Preparation on Retreatment of Curved Root Canals Filled with Different Sealers
Authors: Tavares Karina I. M. C. , Pinto Jader C. , Santos-Junior Airton O. , Duarte Marco A. H. , Guerreiro-Tanomaru Juliane M. , Tanomaru-Filho Mario 
Published: September 2022

Abstract
Objective This study assessed the influence of additional apical preparation on material removal during retreatment of curved root canals filled with different sealers.
Materials and Methods Twelve mesial roots of mandibular molars with two separate canals and curvature between 25 and 35 degrees were selected. The working length was established 1-mm short of the apical foramen, and all the root canals were prepared using ProDesign R (PDR) 25/0.06. After preparation, the root canals were divided in two groups (n = 12) and filled by continuous wave condensation technique with NeoMTA Plus or AH Plus. All the root canals were retreated using rotary ProDesign Logic RT 25/0.08, reciprocating PDR 25/0.06 and apical preparation with PDR 35/0.05. Additional apical preparation was performed with ProDesign Logic (PDL) 50/0.01. The samples were scanned using a Skycan 1176 micro–computed tomography (micro-CT), voxel size 8.74 µm, before and after the retreatment procedures. Percentages of remaining filling material were evaluated.
Statistical Analysis The data were submitted to paired and unpaired t-tests (α = 0.05).
Results Percentage of remaining filling material was similar between the root canals filled with NeoMTA Plus or AH Plus sealer after retreatment using PDR 35/0.05, and after additional apical preparation using PDL 50/0.01 (p > 0.05). However, PDL 50/0.01 significantly decreased the percentage of remaining filling material in the apical third after the additional apical preparation for both sealers (p < 0.05).
Conclusion NeoMTA Plus or AH Plus did not influence the retreatment of curved root canals. ProDesign Logic 50/0.01 promoted greater filling material removal in the apical third.
Anti–Peri-implantitis Bacteria's Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study
Authors: Nugraha Alexander Patera , Ardani I Gusti Aju Wahju , Sitalaksmi Ratri Maya , Ramadhani Nastiti Faradilla , Rachmayanti Desi , Kumala Dina , Kharisma Viol Dhea , Rahmadani Desintya , Puspitaningrum Martining Shoffa , Rizqianti Yuniar , Ari Muhammad Dimas Aditya , Nugraha Albertus Putera , Noor Tengku Natasha Eleena binti Tengku Ahmad , Luthfi Muhammad 
Published: September 2022

Abstract
Objective This study was aimed to investigate RGCBE extract as antioxidant and anti–peri-implantitis bacteria through in vitro study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through in silico study.
Materials
and Methods Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA) and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated in silico. Inhibition zone by diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), and Prevotella intermedia (Pi) were done.
Statistical Analysis the analysis of variance (ANOVA) difference test, and the post-hoc Tukey's Honest Significant Different (HSD) with a different significance value of p<0.05
Results GCA and CA compounds are good drug molecules and it has low toxicity. Chlorogenic acid have higher binding activity than coumaric acid to tumor necrosis factor (TNF)-α, nuclear factor (NF)-κB, receptor activation NF-κB (RANK) and its ligand (RANKL), interleukin (IL)-6, IL-10, runt related transcription factor (RUNX2), receptor activator nuclear Kappa beta Ligand-osteoprotegrin
osteocalcin (RANKL-OPG), osteocalcin, nuclear factor associated T-cell 1 (NFATc1), tartate resistant acid phosphatase (TRAP), peptidoglycan, flagellin, dectin, Hsp70, and Hsp10 protein. RGCB ethanol extract has high antioxidant ability and it has MIC, MBC, and inhibit the growth of Aa, Pg, Fn, and Pi at 50% concentration with significantly different (p=0.0001 and<0.05).
Conclusion RGCB ethanol extract has high antioxidant ability and 50% RGCB ethanol extract may act as strong anti–peri-implantitis bacteria in vitro. In addition, CGA in RGCB potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic in silico.