bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequencies and Predictors of Health Psychology Referrals after Integrative Oncology Consultation
Authors: Powers-James Catherine , Christie Aimee J. , Narayanan Santhosshi , Liu Wenli , Gomez Telma , Cohen Lorenzo , Lopez Gabriel 
Published: January 2022

Abstract
Objective: Health psychology (HP) plays a critical role within a multidisciplinary, integrative oncology team. HP provides coping tools, helping patients engage in healthy lifestyle. HP in integrative oncology is not well established and criteria for referral has not been examined. This study examined characteristics of referral to HP. Methods: A retrospective chart review of 1827 patients seen for consultation in the IMC between January 1st, 2019 and January 13th, 2020 was conducted. Patient assessments included the Edmonton Symptom Assessment Scale, Measure Yourself Concerns and Well-being, and PROMIS-10. Chi-square tests were used to compare categorical variables, Mann-Whitney test for non-normally distributed continuous variables, and t-tests for normally distributed continuous variables comparing those referred and not referred to HP. Results: Referred patients were mostly female (85.4%), White (67.1%), married/partnered (67.7%), obese (42.1%), with breast cancer (52.2%). Compared to those not referred, patients referred to HP were significantly more likely to be female, younger, Black, and had a higher BMI (p ≤ .01). Referred patients reported worse fatigue, sleep, depression, anxiety, well-being, spiritual pain, financial distress, memory, and overall mental health, physical health, and global health (p ≤ .01). Most common concerns of referrals were diet/nutrition, overall health, and stress/anxiety. Compared to non-referred, HP referrals were more likely to prioritize depression, spirituality, and stress/anxiety as their concerns (p ≤ .01). Conclusions: Patient characteristics are well-suited treatment targets for HP, including addressing emotional distress, healthy lifestyle, and quality of life. Our findings can help cancer programs develop strategies to facilitate engagement with psychological counseling.
Prescribing in the Last Year of Life for People Who Die From Cancer: a Retrospective Cohort Study of Medication Prevalence, Trends, and Associations With Demographic and Clinical Factors.
Authors: Mills Sarah E. E. , Buchanan Deans , Donnan Peter T. , Smith Blair H. 
Published: January 2022

Abstract
BACKGROUND: People who die from cancer (‘cancer decedents’) may latterly experience unpleasant and distressing symptoms. Prescribing medication for pain and symptom control is essential for good-quality palliative care; however, such provision is variable, difficult to quantify and poorly characterised in current literature. This study aims to characterise trends in prescribing analgesia, non-analgesic palliative care medication and non-palliative medications, to cancer decedents, in their last year of life, and to assess any associations with demographic or clinical factors. METHODS: This retrospective cohort study examined all 181,247 prescriptions issued in the last year of life to a cohort of all 2,443 cancer decedents in Tayside, Scotland (2013-2015), and linked demographic, and cancer registry datasets using the unique patient-identifying Community Health Index (CHI) number. Anonymised linked data were analysed in Safe Haven using chi-squared test for trend, binary logistic regression and Poisson regression in SPSSv25. RESULTS: In their last year of life, three in four cancer decedents were prescribed strong opioids. Two-thirds of those prescribed opioids were also prescribed laxatives and/or anti-emetics. Only four in ten cancer decedents were prescribed all medications in the ‘Just in Case’ medication categories and only one in ten was prescribed breakthrough analgesia in the last year of life. The number of prescriptions for analgesia and palliative care drugs increased in the last 12 weeks of life. The number of prescriptions for non-palliative care medications, including anti-hypertensives, statins and bone protection, decreased over the last year, but was still substantial. Cancer decedents who were female, younger, or had lung cancer were more likely to be prescribed strong opioids; however, male cancer decedents had higher odds of being prescribed breakthrough analgesia. Cancer decedents who had late diagnoses had lower odds of being prescribed strong opioids.CONCLUSIONS: A substantial proportion of cancer decedents were not prescribed strong opioids, breakthrough medication, or medication to alleviate common palliative care symptoms (including ‘Just in Case’ medication). Many patients continued to be prescribed non-palliative care medications in their last days and weeks of life. Age, gender, cancer type and timing of diagnosis affected patients’ odds of being prescribed analgesic and non-analgesic palliative care medication.
Cancer and Survival: a Qualitative Study of Coping Strategies and Social Conditioning
Authors: Gónzalez-Herrera Antonio , Pujol-Ribera Enriqueta , ESTEVA Magdalena , Ruiz-Marcos Lorena , March Sebastià 
Published: January 2022

Abstract
ObjectiveThis study aims to identify coping strategies in patients with colorectal cancer, in particular the differences between coping strategies during the disease and throughout survival. It also aims to investigate the impact of social determinants on coping strategies and critically reflect on the influence of positive psychology.Methods Qualitative study with in-depth interviews of a purposive sample of 21 colorectal cancer survivors in Majorca (Spain), developed between 2017- 2019. Data was analysed using interpretive thematic analysis.ResultsWe observed different coping strategies during the stages of disease and survival. However, striving toward acceptance and adaptation when facing difficulties and uncertainty, predominate in both stages. Confrontational attitudes are also considered important, as well as encouraging positive rather than negative feelings, which are considered unhelpful and to be avoided.ConclusionsAlthough coping during illness and survival can be classified into common categories (problem and emotion-centred strategies), the challenges of these stages are faced differently. Age, gender and the cultural influence of positive psychology strongly influence both stages and strategies.
Integration Study on Brainstorming and Extenics for Intelligent Innovation in the Big Data Environment
Authors: Li Xingsen , Pi Haibin , Xu Libo , Yang Zhenhao , Liang Zhencheng , Zhang Haolan 
Published: January 2022

Abstract
Brainstorming is widely used in problem solving, which generates a large number of innovative ideas by guiding and stimulating intuitive and divergent thinking. However, in practice, the method is limited by the brain capacity of both individuals and work teams, especially the experience and knowledge they possess. How do ideas come from the brains like storming? Based on the new discipline of Extenics, we propose a test that explores the process of how ideas are brought out of the brain, helping people think multi-dimensional and get more ideas. Extenics has been applied since 1983 to study the extension and transformation of things, and to obtain the creativity to solve contradictory problems intelligently. With the support of information technology and artificial intelligence, we systematically collect more information and knowledge to form a basic-element information base and build human-computer interaction models to make up for the limited information and knowledge in the human brain. In addition, we provide a methodology to help people think positively in a multidimensional way based on the guidance of the Extenics in the brainstorming process. The integration of Extenics with brainstorming method provides a systematic new direction for improving brainstorming method in big data environment. The case study initially verifies the effectiveness of our new method.
Proton Pump Inhibitors Could Ameliorate Cachexia of Gastric Cancer by Down-regulating Vacuolar H+- ATPases and Disrupting PI3K/AKT/mTOR/HIF-1α/PKM2 Signaling Pathway
Authors: Zhuoting Wang , Yunrong Wang , Wei Wei , Wenqi Sun , Xinrong Wu , Chen Min 
Published: January 2022

Abstract
Objective：Our study aimed to investigate whether PPIs could alleviate cachexia of gastric cancer by inhibiting the expression of V-ATPases, downregulating the PI3K/AKT/mTOR/HIF-1α signaling pathway and then inhibiting PKM2.Methods: Human gastric cancer cell lines SGC7901, BGC823 and MKN28 were treated by PPIs or downregulated related factors, and then the expressions of PI3K/AKT/mTOR/HIF-1α/PKM2 signaling pathway, cell apoptosis, cell proliferation and cell migration were analyzed, respectively. In addition, in vivo experiments were conducted to further strengthen our conclusion. Results: Omeprazole, pantoprazole and esomeprazole could respectively inhibit the expression of V-ATPases at a concentration of 10 μg/ml in MKN28 whereas it had no significantly inhibitory effects on the expression of PKM2. Esomeprazole could enhance the inhibitory effects of rapamycin on p-mTOR at a concentration of 20 μg/ml , and could enhance the inhibitory effects of rapamycin on HIF-1α at 10 μg/ml (P<0.05). The mRNA expression of V-ATPases, PI3K, AKT, HIF-1α and PKM2 was inhibited in the SGC7901 cells pretreated previously with esomeprazole (20 μg/ml) for 24 hr. LY294002 with 10 μmol concentration could significantly inhibit protein expression of p-AKT and p-mTOR in the BGC823 cells after 48 hr treatment (P<0.05). After the expression of HIF-1α was knocked down by si-RNA in the BGC823 cell line, the expression of HIF-1 significantly decreased, and the expression of PKM2 decreased in the downstream, while the expression of p-mTOR in the upstream also was simultaneously elevated. Conclusion: PPIs might be a promising agent to alleviate cachexia of gastric cancer according to our in vitro and in vivo experiments.
Renal Tubular Dysfunction Among People Living with HIV on Tenofovir Disoproxil Fumarate in Uganda: A Hospital-Based Cross-Sectional Study
Authors: Ng'umbi John Phillip , Nuwagira Edwin , Kanyesigye Michael , Muyindike Winnie , Muhindo Rose 
Published: January 2022

Abstract
Background
Tenofovir Disoproxil Fumarate (TDF), the most commonly prescribed antiretroviral drug globally is associated with renal tubular dysfunction (RTD) whose magnitude is poorly understood in resource-limited settings. Our goal was to describe the prevalence and factors associated with renal tubular dysfunction in Uganda's people living with HIV(PLHIV) taking TDF-containing regimens.
Methods
We enrolled adult PLHIV receiving TDF-containing antiretroviral regimens from the HIV clinic at Mbarara Regional Referral Hospital. Socio-demographic, clinical and laboratory data were collected from each participant. Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) formula was used to estimate glomerular filtration rate (eGFR) and participants who had any two of, raised urinary excretion of phosphate, uric acid and glycosuria in non-diabetic normal glycemic were said to have renal tubular dysfunction. Logistic regression analysis was done to identify the factors that were independently associated with renal tubular dysfunction.
Results
Of the 145 participants enrolled, 84 (57.9%) were female, and the mean age was 46 (± 9) years. The mean serum creatinine was 0.77 (± 0.12) mg/dl and the mean eGFR of 112 (±24) mL/min/1.73m2. A total of 116/145 (80%) participants had at least one abnormality in parameters of tubular dysfunction; 26 (17.9%) and 3 (2.1%) of the participants had a combination of two or more parameters, respectively. In our study, the prevalence of renal tubular dysfunction was 20% (29/145) (95% CI 14.2-27.3). Female gender was statistically significantly associated with tubular dysfunction, adjusted odds ratio (AOR): 2.75, 95% (CI. 1.05-7.19), p=0.03.
Conclusion
The prevalence of renal tubular dysfunction is high and can occur in patients receiving TDF despite normal serum creatinine. We recommend using urinary abnormalities other than isolated serum creatinine in the detection of renal tubular dysfunction.
Radiograph Measurement of the Posterior Tibial Slope in Normal Chinese Adults: a Retrospective Cohort Study
Authors: Liu Jie , Ding Jianping , Dai Siyu , Yang Jiao , Wang Mengke , Tian Tian , Deng Xiaolong , Li Boyi , Cheng Guohua , Chen Yong 
Published: January 2022

Abstract
Background: Measurement of the posterior tibial slope (PTS) angle has important applications in total knee replacement surgery, high tibial osteotomy, and anterior cruciate ligament reconstruction. The aim of this study was to determine the mean PTS of knee joints in healthy Chinese adults, and to provide data to guide knee surgery in China.Methods: A retrospective analysis was performed using 1,257 (n=1,233, 50.4% male) DR radiograph (X-ray) plain films of participants aged 25-59 years. The picture archiving and communication system (PACS) system was used for the PTS measurement. The PTS was defined as the angle between the vertical line of the tangent of the anterior tibial cortex of the proximal tibia, and the tangent line of the tibial cortex. Two imaging physicians conducted the PTS measurements independently, and both the inter- and intraclass correlation coefficients (ICCs) were estimated.Results: The interobserver ICC was 0.91 (95% confidence interval [CI]: 0.85-0.94), and the intraobserver ICC was 0.90 (95% CI: 0.82-0.94). The mean PTS value was 7.68±3.84° (range: 0-21°). The left PTS was significantly smaller in males than in females (7.22±3.89 vs 8.05±3.60;P=0.005). Additionally, the PTS in participants aged 25-29 years was significantly larger than that in the other age groups(Left side:8.64±3.73 vs 6.92±3.42,7.42±3.75,7.53±3.98;P< 0.001 and Right side:8.68±3.84 vs 7.48±4.21,7.13±3.64,7.66±3.80;P=0.004). There were no significant differences in PTS between the left and right sides. The two-way ANOVA suggested that the differences in PTS between age groups were not affected by sex. Conclusions: This study has provided valuable information regarding the normal PTS values in Chinese adults and it has provided regionalised data to guide knee surgery. Furthermore, this study demonstrated that there were significant differences in PTS based on sex and age, highlighting the need to provide individualized treatment for knee surgery.
LncRNA MIAT Promotes Spinal Cord Injury Recovery in Rats by Regulating RBFOX2-Mediated Alternative Splicing of MCL-1
Authors: He Xin , Zhang Jianan , Guo Yunshan , Yang Xiaowei , Huang Yunfei , Hao Dingjun 
Published: January 2022

Abstract
Background: LncRNA myocardial infarction associated transcript (MIAT) alleviates acute spinal cord injury (ASCI)-induced neuronal cell apoptosis, but the specific mechanism of it involved in regulating SCI progression needs further exploration. Methods: A SCI rat model was established, followed by administration with Adenovirus-mediated MIAT overexpression vector (Ad-MIAT) alone or together with Ad-RBFOX2 (RNA binding fox-1 homolog 2), and rat locomotor capacity was evaluated. Hematoxylin-eosin (HE), Nissl and TUNEL straining were used to analyze spinal cord tissue morphology, neuron loss and apoptosis. Then, PC-12 cells were treated with H2O2 to induce cell injury, and cell viability and apoptosis were determined. Gain- and loss-of-function experiments were carried out to explore the effect of MIAT and RBFOX2 on cell functions. The binding between MIAT and RBFOX2 was confirmed using RNA immunoprecipitation and RNA pull down assays. MCL-1(myeloid cell leukemia sequence 1)-specific steric-blocking oligonucleotides (SBOs) were used to transfer the MCL-1 pre-mRNA splicing pattern from MCL-1L to MCL-1S. Confocal laser microscopy and transmission electron microscopy were used to analyze autophagy flux and lysosome formation.Results: MIAT overexpression promoted motor function recovery, improved morphology of injured tissues, and restrained neuron loss and cell apoptosis in SCI rats, as well as hindered H2O2-caused cell apoptosis in vitro. MIAT stabilized RBFOX2 protein expression by binding to RBFOX2, thereby promoting RBFOX2-induced increase of anti-apoptotic MCL-1L and decrease of pro-apoptotic MCL-1S. Silencing RBFOX2 blocked the inhibitory effect of MIAT on cell apoptosis. And RBFOX2 protected cells from H2O2-caused damage, which was reversed by SBOs. Moreover, overexpression of MCL-1L instead of MCL-1S promoted autophagy activation in cells. Interestingly, co-overexpression of MIAT and RBFOX2 had a better promoting effect on SCI recovery.Conclusion: MIAT mitigated SCI by promoting RBFOX2-mediated alternative splicing of MCL-1. Our findings might provide a promising therapeutic target for SCI.
Effect of Crop Rotation and Straw Application in Combination With Mineral Nitrogen Fertilization on Soil Carbon Sequestration in the Thyrow Long-term Experiment Thy_D5
Authors: Kroschewski Bärbel , Richter Christel , Baumecker Michael , Kautz Timo 
Published: January 2022

Abstract
PurposeThe aim of study was to quantify the temporal change of soil organic carbon content in relation to agricultural management for a dry sandy arable soil and to derive the C sequestration potential.MethodsWe analyzed data from a long-term field experiment with three crop rotations of different cereal proportions, with two levels of straw application (removal/return) in combination with four mineral nitrogen rates (40 … 160 kg ha-1 yr-1). Treatments are arranged in a two-factorial block design with two replicates for each rotation. During the 24-year study period, grain and straw yield of two cereal test crops and soil organic carbon content in topsoil were determined annually from each plot. ResultsSoil organic carbon content was positively influenced by removing non-cereal crops from the rotation and – to a smaller extent – by straw application. Increasing mineral N-fertilization from 40 kg ha-1 yr-1 to higher rates increased grain yield of rye but not barley, increased straw yield of both cereals more, with no effect of higher straw yields on soil organic carbon content.ConclusionDespite the overall soil organic carbon content of the sandy soil under study is comparatively low, the results indicate that agricultural management has a relevant impact on soil carbon stocks. Straw return contributes to carbon sequestration even in rotations with a low potential for reproduction of organic matter. High mineral N-fertilization is not an adequate measure to sequester carbon.
Network Analysis Can Detect Changes In Food Web Stability Produced By Bottom Trawl Fishery In Patagonia
Authors: Manuela Funes , Saravia Leonardo , Cordone Georgina , Iribarne Oscar , Galvan David 
Published: January 2022

Abstract
Demersal fisheries are one of the top anthropic stressors in marine environments. In the long term, some species are more vulnerable to fishery impacts than others, which can lead to permanent changes on the food web. The trophic relationships between predator and prey constitute the food web and it represents a network of the energy channels in an ecosystem. In turn, the network structure influences ecosystem diversity and stability.The first aim of this study was to describe for the first time the food web of the San Jorge Gulf (Patagonia Argentina) with high resolution, i.e. to the species level when information is available. The San Jorge Gulf was subject to intense fisheries thus our second aim is to analyse the food web structure with and without fishery to evaluate if the bottom-trawl industrial fishery altered the network structure and stability. We used several network metrics like: mean trophic level, omnivory, modularity and quasi-sign stability. We included these metrics because they are related to stability and can be evaluated using predator diets that can weight the links between predators and prey. The network presented 165 species organized in five trophic levels. The inclusion of a fishery node adds 71 new trophic links. All weighted and unweighted metrics showed differences between the two networks, reflecting a decrease in stability when fishery was included in the system. Thus, our results suggested a probable change of state of the system. The observed changes in species abundances since the fishery was established, could represent the state change predicted by network analysis. Our results show how changes in the stability of food webs can be used to evaluate the impacts of human activity on ecosystems.
MicroRNA Composition of Plasma Extracellular Vesicles: A Harbinger of Late Cardiotoxicity of Doxorubicin
Authors: Toton-Zuranska Justyna , Sulicka-Grodzicka Joanna , Seweryn Michal , Pitera Ewelina , Kapusta Przemyslaw , Konieczny Pawel , Drabik Leszek , Kolton-Wroz Maria , Chyrchel Bernadeta , Nowak Ewelina , Surdacki Andrzej , Grodzicki Tomasz , Wolkow Pawel 
Published: January 2022

Abstract
Background: The use of doxorubicin is associated with an increased risk of acute and long-term cardiomyopathy. Despite the constantly growing number of cancer survivors, little is known about the transcriptional mechanisms which progress in the time leading to a severe cardiac outcome. It is also unclear whether long-term transcriptomic alterations related to doxorubicin use are similar to transcriptomic patterns present in patients suffering from other cardiomyopathies. Methods: We have sequenced miRNA from total plasma and extracellular vesicles (EVs) from 66 acute lymphoblastic leukemia (ALL) survivors and 61 healthy controls (254 samples in total). We analyzed processes regulated by differentially expressed circulating miRNAs and cross-validated results with the data of patients with clinically manifested cardiomyopathies. Results: We found that especially miRNAs contained within EVs may be particularly informative in terms of cardiomyopathy development and may regulate pathways related to neurotrophin, transforming growth factor beta or epidermal growth factor receptors (ErbB). We identified vesicular miR-144-3p and miR-423-3p as the most variable between groups and significantly correlated with echocardiographic parameters and for plasma: let-7g-5p, miR-16-2-3p. Vesicular miR-144-3p correlates with the highest number of echocardiographic parameters and is differentially expressed in the circulation of patients with dilated cardiomyopathy. We also found that distribution of particular miRNAs between of plasma and EVs (proportion between compartments) e.g., miR-184 in ALL is altered suggesting alterations in secretory and miRNA sorting mechanisms.Conclusions: Our results show that transcriptomic alterations which lead to cardiomyopathy development many years after doxorubicin treatment are reflected in circulating miRNA levels. Among miRNAs related to cardiac function we found vesicular miR-144-3p and miR-423-3p and let-7g-5p, miR-16-2-3p contained in total plasma. Selection of source for such studies (plasma or EVs) is of critical importance as distribution of some miRNA between plasma and EVs is altered in ALL survivors in comparison to healthy people which suggests that doxorubicin-induced changes include miRNA sorting and export to extracellular space.