bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing the efficacy of a couple-focused, tailored eHealth intervention for symptom self-management among men with prostate cancer and their partners: the study protocol
Authors: Song Lixin , Nielsen Matthew E. , Chen Ronald C. , Rini Christine , Keyserling Thomas C. , Idiagbonya Eno , Fuller Gail P. , Northouse Laurel , Palmer Mary H. , Tan Xianming 
Published: January 2022

Abstract
Background
Men with localized prostate cancer often experience urinary, sexual, bowel, and hormonal symptoms; general distress; pain; fatigue; and sleep disturbance. For men in an intimate relationship, these symptoms disrupt couples’ relationships and intimacy. The symptoms also reduce quality of life for both men and their partners, who are often their primary caregivers. Management of the negative effects of cancer and its treatment is a significantly under-addressed supportive care need for these men and their intimate partners. To address these unmet supportive care needs, our interdisciplinary team developed and pilot tested the usability and feasibility of an evidence-based, couple-focused, tailored eHealth intervention, “Prostate Cancer Education & Resources for Couples” (PERC). Based on the adapted stress and coping theoretical framework and developed with stakeholder involvement, PERC aims to improve quality of life for both men and their partners by enhancing their positive appraisals, self-efficacy, social support, and healthy behaviors for symptom management.

Methods
We will test the efficacy of PERC using a population-based, geographically and demographically diverse cohort in a randomized controlled trial. Primary aim: Assess if patients and partners receiving PERC will report greater improvement in their cancer-related quality of life scores than those in the control group (usual care plus the National Cancer Institute prostate cancer website) at 4, 8, and 12 months post-baseline. Secondary aim: Test if patients and partners in PERC will report significantly more positive appraisals and higher levels of coping resources at follow-ups than those in the control group. Exploratory aim: Determine if patient race and ethnicity, education, type of treatment, or couples’ relationship quality moderate the effects of PERC on patient and partner QOL at follow-ups.

Discussion
This study will provide a novel model for self-managing chronic illness symptoms that impact couples’ relationships, intimacy, and quality of life. It addresses the National Institute of Nursing Research’s goal to develop and test new strategies for symptom self-management to help patients and caregivers better manage their illness and improve quality of life. It also responds to calls for programs from the Institute of Medicine and American Cancer Society to address treatment-related effects and improve survivors’ QOL.

Trial registration
CT.gov NCT03489057
Vector microbiota manipulation by host antibodies: the forgotten strategy to develop transmission-blocking vaccines
Authors: Maitre Apolline , Wu-Chuang Alejandra , Aželytė Justė , Palinauskas Vaidas , Mateos-Hernández Lourdes , Obregon Dasiel , Hodžić Adnan , Valiente Moro Claire , Estrada-Peña Agustín , Paoli Jean-Christophe , Falchi Alessandra , Cabezas-Cruz Alejandro 
Published: January 2022

AbstractHuman and animal pathogens that are transmitted by arthropods are a global concern, particularly those vectored by ticks (e.g. Borrelia burgdorferi and tick-borne encephalitis virus) and mosquitoes (e.g. malaria and dengue virus). Breaking the circulation of pathogens in permanent foci by controlling vectors using acaricide-based approaches is threatened by the selection of acaricide resistance in vector populations, poor management practices and relaxing of control measures. Alternative strategies that can reduce vector populations and/or vector-mediated transmission are encouraged worldwide. In recent years, it has become clear that arthropod-associated microbiota are involved in many aspects of host physiology and vector competence, prompting research into vector microbiota manipulation. Here, we review how increased knowledge of microbial ecology and vector-host interactions is driving the emergence of new concepts and tools for vector and pathogen control. We focus on the immune functions of host antibodies taken in the blood meal as they can target pathogens and microbiota bacteria within hematophagous arthropods. Anti-microbiota vaccines are presented as a tool to manipulate the vector microbiota and interfere with the development of pathogens within their vectors. Since the importance of some bacterial taxa for colonization of vector-borne pathogens is well known, the disruption of the vector microbiota by host antibodies opens the possibility to develop novel transmission-blocking vaccines.
Overweight/obesity in adolescents with type 1 diabetes belonging to an admixed population. A Brazilian multicenter study
Authors: Gomes Marilia Brito , Conte Deborah , Drummond Karla Rezende Guerra , Mallmann Felipe , Pinheiro André Araújo , Leal Franz Schubert Lopes , Morales Paulo Henrique , Negrato Carlos Antonio 
Published: January 2022

Abstract
Background
To determine the prevalence of overweight/obesity and associated risk factors in Brazilian adolescents with type 1 diabetes (T1D) and its association with diabetic retinopathy (DR) and chronic kidney disease (CKD).

Methods
This study was performed in 14 Brazilian public clinics in ten cities, with 1,760 patients. 367 were adolescents (20.9%):184 females (50.1%), 176 (48.0%) Caucasians, aged 16.4 ± 1.9 years, age at diagnosis 8.9 ± 4.3 years, diabetes duration 8.1 ± 4.3 years, school attendance 10.9 ± 2.5 years and HbA1c 9.6 ± 2.4%.

Results
95 (25.9%) patients presented overweight/obesity, mostly females. These patients were older, had longer diabetes duration, higher levels of total and LDL-cholesterol, higher prevalence of family history of hypertension, hypertension, undesirable levels of LDL-cholesterol, and metabolic syndrome compared to eutrophic patients. No difference was found regarding ethnicity, HbA1c, uric acid, laboratorial markers of non-alcoholic fatty liver disease (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase).

Conclusions
Almost one quarter of our patients presented overweight/obesity. These patients had higher prevalence of traditional risk factors for micro and macrovascular diabetes-related chronic complications such as diabetes duration, hypertension, high levels of LDL-cholesterol and metabolic syndrome. The majority of the patients with or without overweight/obesity presented inadequate glycemic control which is also an important risk factor for micro and macrovascular diabetes-related chronic complications. No association was found between overweight/obesity with diabetic CKD, DR and laboratorial markers of non-alcoholic fatty liver disease. The above-mentioned data point out that further prospective studies are urgently needed to establish the clinical prognosis of these young patients.
The effectiveness of an intervention designed based on health action process approach on diet and medication adherence among patients with type 2 diabetes: a randomized controlled trial
Authors: Ranjbaran Soheila , Shojaeizadeh Davoud , Dehdari Tahereh , Yaseri Mehdi , Shakibazadeh Elham 
Published: January 2022

Abstract
Background
Diabetes is a major cause of worldwide morbidity and mortality. Diet and medication non-adherence are common among individuals with diabetes, making glycemic control difficult to attain. This study aimed to evaluate an intervention designed based on Health Action Process Approach (HAPA) to improve adherence to diet and medication among patients with type 2 diabetes in Tehran, Iran.

Methods
The study was a randomized controlled trial. A total of 248 patients with type 2 diabetes who had low diet and medication adherence were randomly allocated into two intervention (n  = 124) and control (n  = 124) groups. Intervention group received educational intervention during three months. HAPA constructs, diet and medication adherence, and Hemoglobin A1c (HbA1c) levels were assessed at baseline, one month and six months after the intervention. Mixed Model Analysis was used to compare between and within group changes in the outcomes.

Results
There was a statistically significant improvement in HbA1c levels after six months (7.77 ± 1.36% vs. 8.07 ± 1.52%, 95% CI, p  < 0.001). Diet and medication adherence, intention, task self-efficacy, coping self-efficacy, recovery self-efficacy, action and coping planning, barriers, benefits and perceived social support were significantly improved one month and six months after the intervention (p  < 0.001).

Conclusion
Our intervention designed based on health action process approach led to improvements in diet and medication adherence, and HbA1c among the patients within one and six months.
Trial registration: IRCT, IRCT20151208025431N4. Registered 10 March 2018, https://fa.irct.ir
Drop jumps versus sled towing and their effects on repeated sprint ability in young basketball players
Authors: Zagatto Alessandro M. , Claus Gabriel M. , Dutra Yago M. , de Poli Rodrigo A. , Lopes Vithor H. F. , Goodall Stuart , Loturco Irineu , Boullosa Daniel 
Published: January 2022

Abstract
Background
The aim of the investigation was to compare the occurrence of post-activation performance enhancement (PAPE) after drop jumps, or heavy sled towing, and the subsequent effect on repeated sprint ability (RSA).

Methods
Ten young basketball players (17 ± 1 yrs) performed, in randomized order, RSA test with changes of direction after a standardized warm up followed by drop jumps, heavy sled towing, or no exercise (control condition). Neuromuscular assessments composed of two maximal voluntary contractions of the knee extensors, peripheral nerve stimulation, and surface electromyography (EMG), responses were recorded before and immediately after the RSA. The EMG signal of leg muscles during sprinting were also recorded as well as the blood lactate concentration.

Results
The drop jumps improved the RSA mean time (P = 0.033), total time (P = 0.031), and slowest time (P = 0.029) compared to control condition, while heavy sled towing did not change RSA outcomes (P > 0.05). All conditions exhibited a decrease of doublet high frequency stimulation force (pre-post measurement) (P = 0.023) and voluntary activation (P = 0.041), evidencing the occurrence from peripheral and central components of fatigue after RSA, respectively, but no difference was evident between-conditions. There was a significantly greater EMG activity during sprints for the biceps femoris after drop jumps, only when compared to control condition (P = 0.013).

Conclusion
Repeated drop jumps were effective to induce PAPE in the form of RSA, while heavy sled towing had no effect on RSA performance in young basketball players. Furthermore, both conditioning activities exhibited similar levels of fatigue following the RSA protocol. Thus, drop jumps may be used as an alternative to induce PAPE and thus improve performance during sprints in young male basketball players.
Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation
Authors: Hu Xiaopeng , Wang Hu , Tian Geng. G. , Hou Changliang , Xu Bo , Zhao Xinyan , Zhao Yongqiang , Fang Qian , Li Xinyue , He Lin , Chen Xuejin , Li Shangang , Wu Ji 
Published: January 2022

AbstractBackgroundDuring male meiosis, the Y chromosome can form perfect pairing with the X chromosome. However, it is unclear whether mammalian Female germline stem cells (FGSCs) without a Y chromosome can transdifferentiate into functional haploid spermatid-like cells (SLCs).ResultsWe found that spermatogenesis was restarted by transplanting FGSCs intoKitw/wvmutant testes. Complete meiosis and formation of SLCs was induced in vitro by testicular cells ofKitw/wvmutant mice, cytokines and retinoic acid. Healthy offspring were produced by sperm and SLCs derived from the in vivo and in vitro transdifferentiation of FGSCs, respectively. Furthermore, high-throughput chromosome conformation capture sequencing(Hi-C-seq) and “bivalent” (H3K4me3-H3K27me3) micro chromatin immunoprecipitation sequencing (μChIP-seq) experiments showed that stimulated by retinoic acid gene 8 (STRA8)/protamine 1 (PRM1)-positive transdifferentiated germ cells (tGCs) and male germ cells (mGCs) display similar chromatin dynamics and chromatin condensation during in vitro spermatogenesis.ConclusionThis study demonstrates that sperm can be produced from FGSCs without a Y chromosome. This suggests a strategy for dairy cattle breeding to produce only female offspring with a high-quality genetic background.
Enabling efficient traceable and revocable time-based data sharing in smart city
Authors: Zhang Jiawei , Li Teng , Jiang Qi , Ma Jianfeng 
Published: January 2022

AbstractWith the assistance of emerging techniques, such as cloud computing, fog computing and Internet of Things (IoT), smart city is developing rapidly into a novel and well-accepted service pattern these days. The trend also facilitates numerous relevant applications, e.g., smart health care, smart office, smart campus, etc., and drives the urgent demand for data sharing. However, this brings many concerns on data security as there is more private and sensitive information contained in the data of smart city applications. It may incur disastrous consequences if the shared data are illegally accessed, which necessitates an efficient data access control scheme for data sharing in smart city applications with resource-poor user terminals. To this end, we proposes an efficient traceable and revocable time-based CP-ABE (TR-TABE) scheme which can achieve time-based and fine-grained data access control over large attribute universe for data sharing in large-scale smart city applications. To trace and punish the malicious users that intentionally leak their keys to pursue illicit profits, we design an efficient user tracing and revocation mechanism with forward and backward security. For efficiency improvement, we integrate outsourced decryption and verify the correctness of its result. The proposed scheme is proved secure with formal security proof and is demonstrated to be practical for data sharing in smart city applications with extensive performance evaluation.
Blockchain-IoT peer device storage optimization using an advanced time-variant multi-objective particle swarm optimization algorithm
Authors: Nartey Clement , Tchao Eric Tutu , Gadze James Dzisi , Yeboah-Akowuah Bright , Nunoo-Mensah Henry , Welte Dominik , Sikora Axel 
Published: January 2022

AbstractThe integration of Internet of Things devices onto the Blockchain implies an increase in the transactions that occur on the Blockchain, thus increasing the storage requirements. A solution approach is to leverage cloud resources for storing blocks within the chain. The paper, therefore, proposes two solutions to this problem. The first being an improved hybrid architecture design which uses containerization to create a side chain on a fog node for the devices connected to it and an Advanced Time-variant Multi-objective Particle Swarm Optimization Algorithm (AT-MOPSO) for determining the optimal number of blocks that should be transferred to the cloud for storage. This algorithm uses time-variant weights for the velocity of the particle swarm optimization and the non-dominated sorting and mutation schemes from NSGA-III. The proposed algorithm was compared with results from the original MOPSO algorithm, the Strength Pareto Evolutionary Algorithm (SPEA-II), and the Pareto Envelope-based Selection Algorithm with region-based selection (PESA-II), and NSGA-III. The proposed AT-MOPSO showed better results than the aforementioned MOPSO algorithms in cloud storage cost and query probability optimization. Importantly, AT-MOPSO achieved 52% energy efficiency compared to NSGA-III. To show how this algorithm can be applied to a real-world Blockchain system, the BISS industrial Blockchain architecture was adapted and modified to show how the AT-MOPSO can be used with existing Blockchain systems and the benefits it provides.
Single base station hybrid TOA/AOD/AOA localization algorithms with the synchronization error in dense multipath environment
Authors: Wu Shixun , Li Min , Zhang Miao , Xu Kai , Cao Juan 
Published: January 2022

AbstractMobile station (MS) localization in a cellular network is appealing to both industrial community and academia, due to the wide applications of location-based services. The main challenge is the unknown one-bound (OB) and multiple-bound (MB) scattering environment in dense multipath environment. Moreover, multiple base stations (BSs) are required to be involved in the localization process, and the precise time synchronization between MS and BSs is assumed. In order to address these problems, hybrid time of arrival (TOA), angle of departure (AOD), and angle of arrival (AOA) measurement model from the serving BS with the synchronization error is investigated in this paper. In OB scattering environment, four linear least square (LLS), one quadratic programming and data fusion-based localization algorithms are proposed to eliminate the effect of the synchronization error. In addition, the Cramer-Rao lower bound (CRLB) of our localization model on the root mean-square error (RMSE) is derived. In hybrid OB and MB scattering environment, a novel double identification algorithm (DIA) is proposed to identify the MB path. Simulation results demonstrate that the proposed algorithms are capable to deal with the synchronization error, and LLS-based localization algorithms show better localization accuracy. Furthermore, the DIA can correctly identify the MB path, and the RMSE comparison of different algorithms further prove the effectiveness of the DIA.
Generating comprehensive functioning and disability data worldwide: development process, data analyses strategy and reliability of the WHO and World Bank Model Disability Survey
Authors: Sabariego Carla , Fellinghauer Carolina , Lee Lindsay , Kamenov Kaloyan , Posarac Aleksandra , Bickenbach Jerome , Kostanjsek Nenad , Chatterji Somnath , Cieza Alarcos 
Published: January 2022

AbstractBackgroundData on functioning and disability collected at population level is essential to complement mortality and morbidity, to estimate rehabilitation needs of countries and regions and to monitor the Convention on the Rights of Persons with Disabilities (CRPD) and the Sustainable Development Goals (SDGs). The objective of this paper is to briefly report the development process of the WHO Model Disability Survey, its data analysis strategy as well as its reliability and ability to measure low to high levels of functioning and disability across countries.MethodsThe development process is described in detail, and a secondary analysis using Rasch methods is conducted to report reliability and targeting using data from eight national and two regional implementations of the survey.ResultsThe currently available versions of the Model Disability Survey are presented. The survey has good to very good internal reliability and good targeting in all included countries.ConclusionThe participatory and evidence-based development, consideration of the expertise of stakeholders, the availability of previously developed ICF-based surveys, and WHO tools targeting functioning and disability are reflected in its good to very good psychometric properties. The survey has been implemented to date in Afghanistan, Cameroon, Chile, Costa Rica, India, Laos, Pakistan, Philippines, Sri Lanka, and Tajikistan, and is used to inform policy-making, to monitor the CRPD and SDGs and to plan the delivery of rehabilitation services.
Cascading effect of source limitation on the granivore-mediated seed dispersal of Korean pine (Pinus koraiensis) in secondary forest ecosystems
Authors: Wang Jing , Geoff Wang G. , Li Rong , Sun Yirong , Yu Lizhong , Zhu Jiaojun , Yan Qiaoling 
Published: January 2022

Abstract
Background
Granivore-mediated seed dispersal is susceptible to changes in seed availability and silvicultural management, which alters synzoochorous interactions in the antagonism-mutualism continuum and affects the seed dispersal effectiveness (SDE), and eventually, the plant recruitment. We conducted a whole-year study of seed addition to quantify the granivores-Korean pine (Pinus koraiensis) synzoochorous interactions and the SDE in the same secondary forests with two treatments. Both treatments had seed source limitations: one was caused by the disappearance of Korean pine due to the historical disturbance, the other by pinecone harvesting in Korean pine plantations adjacent to the secondary forests. Thinning with different intensities (control, 25%, and 50%) were also performed to further explore the synzoochorous interactions and SDE in response to silvicultural management in the second type of forests.

Results
Source limitation increased the proportion of pre- and post-dispersal seed predation, and made the granivores-Korean pine interaction shift more towards antagonism, with the estimated SDE of 2.31 and 3.60, respectively, for the secondary forests without and with Korean pine. Thinning with different intensities did not alleviate the reactions towards antagonism but altered SDE; granivores occurrence decreased, but the proportion of pre- and post-dispersal seed predation increased, resulting in a fivefold decreased seedling recruitment in 25% thinning (the lowest SDE of 0.26).

Conclusion
The source limitation coupling thinning biased the synzoochorous interactions more towards antagonism and significantly lowered granivore-mediated SDE, which limited the successful recruitment of Korean pine in secondary forests. Forest managers should control pinecone harvesting, protect the synzoochorous interaction, and take into account masting event for Korean pine regeneration in the future.
Reconsidering the structure of the questionnaire for eudaimonic well-being using wide age-range Japanese adult sample: An exploratory analysis
Authors: Ishii Yu , Sakakibara Ryota , Komoto Kubota Aiko , Yamaguchi Kazuhiro 
Published: January 2022

AbstractBackgroundAn increasing amount of research is now highlighting the importance of approaching issues of happiness through eudaimonic well-being. However, the literature does not conclusively show a full understanding of the construct of eudaimonic well-being, as previous studies primarily focused on younger samples from Western countries and only a few studies have attempted to explore its psychological construct through exploratory approaches. Therefore, we conducted a survey among a wide range of age groups in Japan to capture the psychological construct of eudaimonic well-being, through an exploratory analytic approach using Questionnaire for Eudaimonic Wellbeing (QEWB).MethodsA total of 1126 Japanese participants (580 females, 546 males) were included for analysis. Participants were divided into three age groups according to their age, including 10s to 20s (18–29 years), 30s to 40s (30–49 years) and 50s to 60s (50–69 years). After narrowing down the total number of factors by exploratory structural equation modeling (ESEM), we conducted an ESEM and bifactor ESEM with oblique goemin and oblique bi-geomin rotations for choosing and assessing the final model based on the rotated results and its interpretability.ResultsThe results of a parallel analysis and goodness-of-fit indices obtained by ESEM indicated that the QEWB consisted of three or more factors. Both a three-to-six factor and bifactor ESEM with oblique goemin rotation showed that three-factor structure for the 30s to 40s and 50s to 60s and four-factor structure for the 10s to 20s should be chosen, respectively. “Deep and Meaningful Engagement,” a factor only relevant to the 10s to 20s may be an expanded version of what original paper called the Intense Involvement in Activities, with more emphasis on the enthusiastic attitude one has towards activities.ConclusionsThe structure of eudaimonic well-being may differ across cultures and ages, thus requiring further investigation in the field.