bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development towards low carbon and sustainable agriculture in Finland is possible with moderate changes in land use and diets
Authors: Lehtonen Heikki , Rämö Janne 
Published: November 2022

AbstractFood security under climate change, several sustainability problems, and ambitious climate targets are considered challenges for agriculture and food sectors in many countries. Since agricultural production and its land use produce appr. 20% of greenhouse gas (GHG) emissions of Finland, reducing agricultural GHG emissions is important for meeting national target of climate neutrality by 2035. Healthier food diets, maintenance of biodiversity, and reduced nutrient leaching from agriculture are also required for a more sustainable food economy. This paper aims to show how agriculture in Finland, traditionally dominated by livestock production, could decrease GHG emissions significantly and simultaneously respond to other sustainability concerns. Our results, based on economic modelling of the agricultural sector, suggest that moderate changes in food diets and land use can reduce GHG emissions of agriculture by more than 40% by 2050 if productivity growth and policy changes support the overall change in the agriculture and food sector. Adaptation to climate change, e.g. more higher crop yields efficient input use, is necessary for productivity growth. Decreased demand for meat and decreased cultivation of feed crops would decrease GHG emissions and free up land for carbon sequestration through afforestation. Whilst healthier food diets imply less livestock and increased imports of protein crops for food, a reasonable volume of livestock production is useful for maintaining food security, grasslands, crop rotations, soil carbon, and biodiversity. We conclude that transition to low carbon and more sustainable agriculture is possible without risking food security at northern latitudes.
Cricopharyngeal Myotomy; a Rescue Surgery for Dysphagia in Lateral Medullary Syndrome
Authors: Shenoy S Vijendra , K Kshithi , Parvathareddy Navya , Dhawan Saksham 
Published: November 2022

AbstractLateral medullary syndrome/Wallenberg syndrome, is a neurological disorder occurring due to ischemia in the lateral part of medullary oblongata resulting in wide range of symptoms. Dysphagia is usually exhibited in severe and persistent form in LMS. Hence timely intervention is mandatory before the patient further worsens. We describe a case of Lateral medullary syndrome with persisitent dysphagia who was managed successfully with cricopharyngeal myotomy.
User-centered visual explorer of in-process comparison in spatiotemporal space
Authors: Yu Dong , Ian Oppermann , Jie Liang , Xiaoru Yuan , Vinh Nguyen Quang 
Published: November 2022

Abstract
We propose a user-centered visual explorer (UcVE) for progressive comparing multiple visualization units in spatiotemporal space. We create unique unit visualization with the customizable aggregated view based on the visual metaphor of flower bursts. Each visualization unit is encoded with the abstraction of spatiotemporal properties. To reduce user cognition load, UcVE allows users to visualize, save, and track in-the-process exploration results. In coordination of storage sequence and block tracking views, UcVE can facilitate comparison with multiple visualization units concurrently, selected from historical and current exploration results. UcVE offers a flexible geo-based layout, with aggregation functions and temporal views of the timeline with categorized events, to maximize the user’s exploration capabilities. Finally, we demonstrate the usefulness by using COVID-19 datasets, case studies with different user scenarios, and expert feedback.

Graphical abstract
Kruppel-like factor 13 inhibits cell proliferation of gastric cancer by inducing autophagic degradation of β-catenin
Authors: Ding Youxiang , Xu Yuting , Fu Yao , Zhang Heng , Zhao Li , Fan Xiangshan 
Published: November 2022

AbstractZinc protein KLF13 is a tumor-suppressive member of Kruppel-like factors family, and yet the effect of KLF13 on gastric cancer has not been reported. Here, we aimed to investigate the role of KLF13 in gastric cancer and explored underlying molecular mechanisms. Firstly, it was found that KLF13 expression was significantly decreased in gastric cancer tissues and cancer cells compared with adjacent normal tissues and normal gastric epithelial cells, respectively. KEGG_Pathway and GO_BP analyses suggested that KLF13 was associated with CELL_CYCLE and CELL_PROLIFERATION. Then, our results further demonstrated that KLF13 could obviously inhibit gastric cancer proliferation and induce cell arrest at G2/M phase. Mechanistically, KLF13 decreased expressions of β-catenin and its target genes, CCND1 and MYC, via triggering autophagic degradation of β-catenin. KLF13 up-regulation facilitated co-localization and binding of β-catenin with autophagy protein p62, and exogenous overexpression of β-catenin or blocking autophagy process appeared to reverse KLF13-induced inhibition of gastric cancer proliferation. Furthermore, KLF13 overexpression promoted the expression of ubiquitin-conjugating enzyme E2, Ubc13 which is responsible for catalyzing the synthesis of 'Lys-63'-linked polyubiquitin chains and increased the binding of β-catenin with E3 ubiquitin ligase, TRAF6. In vivo, KLF13 overexpression also suppressed xenograft tumor growth of gastric cancer and down-regulated expressions of Ki67, β-catenin, Cyclin D1, and c-Myc in tumor tissues. Collectively, these data firstly demonstrated the involvement of KLF13 in inhibiting cell proliferation of gastric cancer through promoting autophagy-dependent degradation of β-catenin, which reinforced the evidence for suppressive roles of KLF13 in human tumors.
Non-Financial Losses Incurred by a Traffic Accident Perpetrator
Authors: Miyoshi Hiroaki , Taguchi Satoshi , Yamamoto Tatsushi , Watanabe Shoji 
Published: November 2022

AbstractThe drivers of vehicles equipped with active-safety systems are less likely to be the responsible parties in traffic accidents. However, this benefit cannot be monetarily evaluated because monetary values for non-financial losses incurred by perpetrators have thus far been entirely unexplored. This paper estimates the value using stated-preference survey. The main finding is that monetary value for non-financial losses incurred by a perpetrator of fatal accident (for cases in which the perpetrator was 100% responsible for the accident) should be set at the level approximately equal to that of non-financial losses to an accident victim.
Misogynoir: challenges in detecting intersectional hate
Authors: Kwarteng Joseph , Perfumi Serena Coppolino , Farrell Tracie , Third Aisling , Fernandez Miriam 
Published: November 2022

Abstract“Misogynoir” is a term that refers to the anti-Black forms of misogyny that Black women experience. To explore how current automated hate speech detection approaches perform in detecting this type of hate, we evaluated the performance of two state-of-the-art detection tools, HateSonar and Google’s Perspective API, on a balanced dataset of 300 tweets, half of which are examples of misogynoir and half of which are examples of supporting Black women and an imbalanced dataset of 3138 tweets of which 162 tweets are examples of misogynoir and 2976 tweets are examples of allyship tweets. We aim to determine if these tools flag these messages under any of their classifications of hateful speech (e.g. “hate speech”, “offensive language”, “toxicity” etc.). Close analysis of the classifications and errors shows that current hate speech detection tools are ineffective in detecting misogynoir. They lack sensitivity to context, which is an essential component for misogynoir detection. We found that tweets likely to be classified as hate speech explicitly reference racism or sexism or use profane or aggressive words. Subtle tweets without references to these topics are more challenging to classify. We find that the lack of sensitivity to context may make such tools not only ineffective but potentially harmful to Black women.
The Systemic Implications of the Supranational Legal Order for the Practice of the Rule of Law
Authors: Grabowska-Moroz Barbara 
Published: November 2022

AbstractThe article presents the main rule of law guarantees and the critique of the rule of law as it is applied in the European Union. Analysis is supplemented with the results of the European Parliament election survey which was conducted as a part of RECONNECT project. Despite the fact that rule of law topics reach the European media headlines on a regular basis, the rule of law was not perceived as the most important one by the respondents. Meanwhile Treaty-based mechanisms aimed at protecting EU fundamental values, such as Article 7 TEU and the infringement procedure, reflect the dual legal as well as political nature of the rule of law. The article analyses how the EU constitutional structure affects the practices of the rule of law—both at the supranational and domestic level—and offers some key recommendations on how to tackle deficiencies in the field of the rule of law.
Impact of Bisphenol A on Structure and Function of Mitochondria: A Critical Review
Authors: Nayak Divyani , Adiga Divya , Khan Nadeem G. , Rai Padmalatha S. , Dsouza Herman Sunil , Chakrabarty Sanjiban , Gassman Natalie R. , Kabekkodu Shama Prasada 
Published: November 2022

AbstractBisphenol A (BPA) is an industrial chemical used extensively to manufacture polycarbonate plastics and epoxy resins. Because of its estrogen-mimicking properties, BPA acts as an endocrine-disrupting chemical. It has gained attention due to its high chances of daily and constant human exposure, bioaccumulation, and the ability to cause cellular toxicities and diseases at extremely low doses. Several elegant studies have shown that BPA can exert cellular toxicities by interfering with the structure and function of mitochondria, leading to mitochondrial dysfunction. Exposure to BPA results in oxidative stress and alterations in mitochondrial DNA (mtDNA), mitochondrial biogenesis, bioenergetics, mitochondrial membrane potential (MMP) decline, mitophagy, and apoptosis. Accumulation of reactive oxygen species (ROS) in conjunction with oxidative damage may be responsible for causing BPA-mediated cellular toxicity. Thus, several reports have suggested using antioxidant treatment to mitigate the toxicological effects of BPA. The present literature review emphasizes the adverse effects of BPA on mitochondria, with a comprehensive note on the molecular aspects of the structural and functional alterations in mitochondria in response to BPA exposure. The review also confers the possible approaches to alleviate BPA-mediated oxidative damage and the existing knowledge gaps in this emerging area of research.
Advancing workforce diversity by leveraging the Clinical and Translational Science Awards (CTSA) program
Authors: Locklear Tracie , Lewis Roslyn , Calhoun Faye , Li Andy , Dickerson Kathryn C. , McMillan Amanda , Davis Lisa , Dzirasa Kafui , Weinfurt Kevin P. , Grambow Steven C. 
Published: November 2022

Abstract
Clinical trials continue to disproportionately underrepresent people of color. Increasing representation of diverse backgrounds among clinical research personnel has the potential to yield greater representation in clinical trials and more efficacious medical interventions by addressing medical mistrust. In 2019, North Carolina Central University (NCCU), a Historically Black College and University with a more than 80% underrepresented student population, established the Clinical Research Sciences Program with support from the Clinical and Translational Science Awards (CTSA) program at neighboring Duke University. This program was designed to increase exposure of students from diverse educational, racial, and ethnic backgrounds to the field of clinical research, with a special focus on health equity education. In the first year, the program graduated 11 students from the two-semester certificate program, eight of whom now hold positions as clinical research professionals. This article describes how leveraging the CTSA program helped NCCU build a framework for producing a highly trained, competent, and diverse workforce in clinical research responsive to the call for increased diversity in clinical trial participation.
Feasibility of using Facebook for HIV prevention: Implications for translational research among justice-involved women who use drugs in rural Appalachia
Authors: Staton Michele , Dickson Megan F. , Pike Erika , Young Sean 
Published: November 2022

Abstract

Background:
Justice-involved women from rural Appalachia face significant barriers to the utilization of evidence-based HIV prevention interventions in spite of high rates of injection drug use and risky sexual practices. Adapting evidence-based practices to incorporate the cultural uniqueness of the target population is needed in order to advance translational and clinical science in this area. This study provides a descriptive overview of indicators of feasibility and acceptability of an adapted version of the National Institute on Drug Abuse Standard HIV prevention intervention for delivery using Facebook through a small randomized controlled pilot study with rural Appalachian women.

Method:
Study methods include the random selection of rural Appalachian women from two local jails, screening for study eligibility, baseline data collection, random assignment to study interventions, and follow-up in the community three months post-release.

Results:
Results indicate that the feasibility of the approach was supported through study enrollment of the target population who reported regular Facebook use and HIV risk behaviors including drug use and sex. Acceptability of the intervention was demonstrated through enrollment in the study intervention, engagement in the intervention through Facebook, and indicators of HIV/HCV knowledge.

Conclusions:
Study findings contribute to the critical and unmet need to advance translational science on the delivery of evidence-based prevention interventions in real-world rural Appalachian settings to understudied, vulnerable individuals who are often overlooked in targeted prevention efforts.
When sequence matters: the processing of contextually biased German verb–object metaphors
Authors: Ronderos Camilo R. , Guerra Ernesto , Knoeferle Pia 
Published: November 2022

AbstractSeveral studies have investigated the comprehension of decontextualized English nominal metaphors. However, not much is known about how contextualized, non-nominal, non-English metaphors are processed, and how this might inform existing theories of metaphor comprehension. In the current work, we investigate the effects of context and of sequential order for an under-studied type of construction: German verb–object metaphors. In two visual-world, eye-tracking experiments, we manipulated whether a discourse context biased a spoken target utterance toward a metaphoric or a literal interpretation. We also manipulated the order of verb and object in the target utterances (e.g.,Stefan interviewt eine Hyäne, ‘Stefan interviews a hyena’, verb→object; andStefan wird eine Hyäne interviewen, ‘Stefan will a hyena interview’, object→verb). Experiment 1 shows that contextual cues interacted with sequential order, mediating the processing of verb–object metaphors: When the context biased toward a metaphoric interpretation, participants readily understood the object metaphorically for the verb→object sequence, whereas they likely first understood it literally for the object→verb sequence. Crucially, no such effect of sequential order was found when context biased toward a literal interpretation. Experiment 2 suggests that differences in processing found in Experiment 1 were brought on by the interaction of discourse context and sequential order and not by sequential order alone. We propose ways in which existing theoretical views could be extended to account for these findings. Overall, our study shows the importance of context during figurative language comprehension and highlights the need to test the predictions of metaphor theories on non-English and non-nominal metaphors.
Snapshot of COVID-19 superinfections in Marseille hospitals: where are the common pathogens?
Authors: Le Glass Elisabeth , Raoult Didier , Dubourg Grégory 
Published: November 2022

Abstract
Episodes of bacterial superinfections have been well identified for several respiratory viruses, notably influenza. In this retrospective study, we compared the frequency of superinfections in COVID-19 patients to those found in influenza-positive patients, and to controls without viral infection. We included 42 468 patients who had been diagnosed with COVID-19 and 266 261 subjects who had tested COVID-19 negative between 26 February 2020 and 1 May 2021. In addition, 4059 patients were included who had tested positive for the influenza virus between 1 January 2017 and 31 December 2019. Bacterial infections in COVID-19 patients were more frequently healthcare-associated, and acquired in ICUs, were associated with longer ICU stays, and occurred in older and male patients when compared to controls and to influenza patients (P < 0.0001 for all). The most common pathogens proved to be less frequent in COVID-19 patients, including fewer cases of bacteraemia involving E. coli (P < 0.0001) and Klebsiella pneumoniae (P = 0.027) when compared to controls. In respiratory specimens Haemophilus influenzae (P < 0.0001) was more frequent in controls, while Streptococcus pneumoniae (P < 0.0001) was more frequent in influenza patients. Likewise, species associated with nosocomial transmission, such as Pseudomonas aeruginosa and Staphylococcus epidermidis, were more frequent among COVID-19 patients. Finally, we observed a high frequency of Enterococcus faecalis bacteraemia among COVID-19 patients, which were mainly ICU-acquired and associated with a longer timescale to acquisition.
The effect of the Dutch financial assessment framework on the mortgage investments of pension funds
Authors: Kim Yeorim , Mastrogiacomo Mauro 
Published: November 2022

AbstractWe investigate the cause of the increase in mortgage investments by pension funds after the financial crisis. We show that, after the introduction of the new financial assessment framework in 2015, funds that experienced larger reductions in the funding ratio during the 2008–2012 crisis invested more in mortgages. We test the hypothesis that a past recovery mode has motivated pension funds to invest more in mortgages after the crisis. Funds that seek to further hedge their interest rate risks aim for a different risk/return investment profile. Mortgages could contribute to a less risky portfolio, as they have become even safer since the introduction of several new regulations in 2013. Recovery modes after the crisis combined with the new framework are a cause of the recent surge in mortgage holding by pension funds; we find that this led to a 39% increase in their mortgage investments, despite the fact that these are still low relative to the overall investments of pension funds.
Neural ODE Differential Learning and Its Application in Polar Motion Prediction
Authors: Kiani Shahvandi Mostafa , Schartner Matthias , Soja Benedikt 
Published: November 2022

AbstractThis paper introduces a new learning algorithm for accurate, physically driven time series prediction. The fundamental assumption behind the method is that the phenomena follow Ordinary Differential Equations. We investigate the general case where the time series follows an ODE of degree . The resulting method is a learning algorithm based on the finite differences between the values of time series. We present the application of the method in the field of geodesy for polar motion prediction, the main objective of the present paper. We show that in this application, the linear form of the method is sufficient and offers competitive predictive performance. We present a baseline solution, in which we use historical polar motion time series from 1976 to predict up to the year 2020. The prediction horizon in this case is short‐term (up to 10 days into the future). In addition, we compare the prediction accuracy in the short‐term horizon with the results of the best performing model in the first Earth Orientation Prediction Comparison Campaign. On average, a 53% improvement in prediction performance is achieved. In further analyses, we compare the prediction accuracy for both short‐term and long‐term against the results of state‐of‐the‐art methods, namely Multichannel Singular Spectrum Analysis, and a combination of Singular Spectrum Analysis and Copula sampling. We show that the proposed method in this paper can outperform the mentioned two methods in both short and long‐term horizons, with an average improvement of the prediction performance of 54% and 52%, respectively.
Global Climatology of Extratropical Cyclones From a New Tracking Approach and Associated Wave Heights From Satellite Radar Altimeter
Authors: Lodise John , Merrifield Sophia , Collins Clarence , Rogowski Peter , Behrens James , Terrill Eric 
Published: November 2022

AbstractExtratropical cyclones (ECs) produce comparable wave heights and hazardous sea states to those under hurricanes. With strong wind speeds and considerably larger diameters, the impact of ECs on the global wave climate is substantial. Because ECs occur more frequently, move more quickly, and exist in a large variety of sizes and shapes, these storms are not as well documented. Here, we present findings from a global EC tracking algorithm aimed at creating an EC database of wave producing storms. We focus on the major ocean basins of extratropical cyclone activity: The North Atlantic, North Pacific, and Southern Oceans. Our tracking algorithm uses mean sea level pressure fields from the European Centre for Medium‐Range Weather Forecasts (ECMWF) high resolution, advanced data assimilating, ERA5 reanalysis over the years 1979–2020. The 42 year‐long data set of thousands of cyclone tracks allows seasonal patterns and longer‐term trends of EC activity to be analyzed in these ocean regions. In addition, we employ 36 years of satellite radar altimeter‐derived significant wave height (Hs) data from 14 inter‐calibrated satellite missions to study the wave climate induced by the identified ECs in each basin. The resulting wave climatology compares well with previous results in the mid to high latitudes. We then analyze average wave heights under different EC characteristics, including cyclone translational speed and maximum winds, which have strong effects on wave height variability. Finally, a brief analysis of EC and wave climate under positive and negative phases of the North Atlantic Oscillation is presented.