bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamification in higher education: A review of the literature
Authors: Castillo-Parra Byron , Hidalgo-Cajo Byron Geovanny , Vásconez-Barrera Milton , Oleas-López Julio 
Published: June 2022

Gamification is a learning technique that transfers the mechanics of games to the educational environment in order to achieve better pedagogical results mediated by technological tools, this technique is used as an alternative to the traditional teaching methodology that is increasingly used in higher education, which is why the objective of the study is to know how gamification influences the teaching-learning process in higher education. In order to answer this question, a systematic review of the literature is carried out, based on the analytical method, using the scientific databases Web of Science and SCOPUS for the search of information. The impact of gamification within the formative context is significant since its evolution as a didactic strategy manages to meet the educational objectives improving learning outcomes, its application is methodical that considers the principles and appropriate elements of the game to solve problems and promote learning, which causes the change of student behavior, because it takes advantage of the main motivations of human behavior in two ways connected to each other: reinforcements and emotions, thus obtaining effective and motivated learning, reaching several types of knowledge, such as: declarative, conceptual, regulated, procedural, soft skills, affective and psychomotor mastery, which demonstrates its versatility and usefulness in learning environments.

Keywords: Game based learning, Higher education, Edugame, serious game, gamification.
The Substitution of Fresh Moringa Leaves and Moringa Leaves Powder on Organoleptic and Proximate Characteristics of Pudding
Authors: Srimiati Mia , Agestika Lina 
Published: June 2022

Background: Moringa Oleifera leaves "Marungga" contain fiber, vitamins, minerals, and polyphenol compounds that potential to fulfill nutritional requirements among children and adults. The product development often utilized Moringa leaves powder rather than the fresh ones. The powdering process might reduce the nutritional content while using fresh Moringa leaves is more applicable for the local community. However, the strong taste and aroma of Moringa leaves could influence the individual acceptance of a food product. Pudding is a simple and easy-to-make food product at the household level.
Purpose: This study aimed to compare the effectiveness of fresh Moringa leaves substitution compared with Moringa leaves powder on pudding product acceptance and proximate characteristics.
Methods: This was an experimental study with a complementary randomized design. The substitution of fresh Moringa leaves was 0%,20%,30%, while Moringa leaf powder was 0%, 5%, 10%. We conducted an organoleptic test, hedonic test, and proximate analysis of chosen formulations. Statistical analysis included Analysis of Variance (ANOVA), Duncan's multiple range test, and t-test.
Results: The chosen formula based on the hedonic test was the 20% of fresh Moringa leaf substitution (FML2) with a score of 3.64, and 5% of Moringa leaf flour (FMP1) with a score of 4.10. A significant difference between the two formulations was their texture; FMP1 had a hard texture than FML2. The protein, fat, carbohydrate, and total calorie content of those formulations were significantly different, but not for the ash content.
Conclusion: Substitution used fresh leaves utilized more Moringa leaves and improved pudding nutrients contents than powder type.
Nutrition Knowledge, Breastfeeding and Infant Feeding Practice of Mothers in Cirebon Regency
Authors: Ekawidyani Karina Rahmadia , Khomsan Ali , Dewi Mira , Thariqi Yughni Azizah 
Published: June 2022

Background: Exclusive breastfeeding should be supported by early initiation of breastfeeding (EIBF), provision of colostrum and not providing pre-lacteal feeding.
Objectives: The study objective was to analyze nutritional knowledge and factors related to breastfeeding and feeding practices of lactating mothers.
Methods: A cross-sectional study was conducted in March–November 2020 in Sibubut, Kedungdalem, and Bayalangu Kidul Villages, Cirebon Regency. Study respondents were 44 lactating mothers with under six months infants. Mothers’ nutritional knowledge of breastfeeding and breastfeeding/feeding practice were obtained using a validated questionnaire, while the food consumption data of mothers was obtained from two days of 24-hour food recall (weekday and weekend). Spearman’s correlation test and Chi-Square analysis were used to analyze the correlation between variables, while the Mann-Whitney test was used to analyze the difference in nutritional knowledge and breastfeeding/infant feeding practice variables based on education level.
Results: Family characteristics (age, mother’s education and occupation, household income, parity, family size, and Body Mass Index (BMI) were not correlated with breastfeeding/infant feeding practice (p=0.427; 0.136; 0.481; 0.056; 0.699; 0.241; 0.547, respectively). There was no significant correlation between nutritional knowledge and breastfeeding/infant feeding practice of mothers (p=0.728). No significant difference was found in the nutritional knowledge of breastfeeding (p=0.828) and breastfeeding/feeding practice of infants (p=0.572) between mothers with education > elementary school and < elementary school. More mothers with low education provided pre-lacteal food than mothers with higher education (p =0.046).
Conclusions: The breastfeeding/feeding practice of mothers are still poor regardless of education level. Nutrition education for breastfeeding mothers is required to encourage good breastfeeding/infant feeding practices.
The Integrated Nutrition Education on eHealth Intervention and Its Effectiveness on Improvement of Anthropometric Status and Behavioural Outcomes of Obese Adults: A Systematic Review
Authors: Rusyantia Anggun , Khomsan Ali , Kusharto Clara Meliyanti , Pratomo Hadi 
Published: June 2022

Background: The problem of overnutrition has become an epidemic issue at the global level. As one of the effective ways to prevent and overcome obesity, nutrition education is growing by utilizing eHealth media as a message delivery channel.
Objectives: To identify studies that integrate nutrition education with eHealth-based technology in the prevention and control of obesity, behavioral theory and BCT (Behaviour Change Technique), their effectiveness in improving the anthropometric status and behavioral outcomes in obese adults.
Discussion: Article searches were conducted using PubMed, Science Direct, ProQuest, and using manual search Google Scholar in reputable journals in the last ten years, and 17 English articles were obtained. Two forms of communication channels and activities were used to deliver nutrition education messages, namely interpersonal channels and internet-based mass media with or without assistance. Mobile applications were the most widely used as a messaging tool. The most frequently used theory was Social Cognitive Theory, and the majority of BCT were self-monitoring, goal setting, and feedback. The eHealth method (online) gave the same results on anthropometric status, physical activity, and treatment adherence compared to face-to-face (offline) by providing the same BCT-based obesity management intervention.
Conclusions: Integrating nutrition education into eHealth media channels that emphasizes modification of eating behavior and physical activity has a significant effect on improving anthropometric status but was inconsistent on eating behavior and physical activity outcomes in adults with short-term intervention (≤3.5 months/ 14 weeks). This effect will give benefit the outcomes if followed by personal or group mentoring accompanied by well-design BCT.
Comparison of Platelet-Lymphocyte Ratio Before and After Chemotherapy in Nasopharyngeal Carcinoma Based on Histopathology
Authors: Aksmitayani Aksmitayani , Kadir Abdul , Perkasa Muhammad Fajar , Punagi Abdul Qadar 
Published: June 2022

Introduction: Nasopharyngeal carcinoma (NPC) is a non-lymphomatous squamous cell carcinoma in the nasopharyngeal epithelial layer which can be classified into three categories with different prognosis based on histopathological examination. This study aimed to compare platelet-lymphocyte ratio (PLR) in NPC patients before and after chemotherapy based on histopathological type. Method: this cohort study recorded data from medical records. The histopathological type, chemotherapy regimen, clinical stage, and PLR of NPC patients were recorded and compared before and after therapy using paired T-test and Wilcoxon test. The prognostic strength of PLR and the value of the cut-off point was determined by looking at the Area Under Curve (AUC) value using the Receiver Operating Characteristic (ROC) curve method. Results: A total of 44 NPC patients received chemotherapy for three cycles, including 21 patients with NPC type-2 and 23 patients with NPC type-3. There were significant differences in the average PLR before and after undergoing three cycles of chemotherapy in type III NPC (p=0.023). At the same time, there were no statistically significant differences in type-II NPC (p=0.131). The prognostic ability of pre-chemotherapy PLR in assessing disease progression in type II NPC was good (AUC=0.763) with 100.0% sensitivity and 73.68% specificity. In type III NPC, the prognostic ability of PLR was very good (AUC 0.881) with 100% sensitivity value and 76.19% specificity. Conclusion: A significant PLR decrease was obtained after the 3rd cycle of chemotherapy in type III NPC following brexel-cisplatin regimen but not in type II NPC. This is probably due to the use of a cisplatin therapy regimen that is more responsive to type III NPC. In addition, examining PLR value before undergoing chemotherapy can be a predictor in assessing disease progression in type III NPC patients.
“Manisa bozaka” or “Counting grass”: Global Grassy Group guide to understanding and measuring the functional and taxonomic composition of ground layer plants
Authors: Lehmann Caroline E.R. , Archibald Sally , Vorontsova Maria S. , Hempson Gareth P. , Wieczorkowski Jakub D. 
Published: June 2022

Abstract
Grassy biomes span more than 40% of the global land surface and are central to people, biodiversity and Earth System functioning. There is however limited standardised measurement of herbaceous taxonomic and functional composition in grassy biomes that inhibits the development of a comparative understanding of grassy biomes among geographic regions. Here, we present a protocol for the measurement of herbaceous richness and composition to motivate for much needed data standardisation in the measurement of grassy biomes. The data collection protocol and associated data management system are designed to have utility for fields of research ranging from phylogenetics and taxonomy to functional, community and ecosystem ecology. The described data collection protocol links to a data management system designed to foster collaboration and equity among biologists and ecologists working on herbaceous plants and grassy biomes.
Transhiatal Chest Drainage in Transmediastinal Esophagectomy for Esophageal Cancer: A Retrospective Study
Authors: Hisakura Katsuji , Ogawa Koichi , Akashi Yoshimasa , Kim Jaejeong , Moue Shoko , Ohara Yusuke , Owada Yohei , Hashimoto Shinji , Enomoto Tsuyoshi , Oda Tatsuya 
Published: June 2022

Abstract
Background: Transmediastinal esophagectomy for esophageal cancer occasionally causes postoperative accumulation of pleural effusion despite the preservation of the mediastinal pleura. Transhiatal chest drainage has been reported to be useful for thoracic esophagectomy; however, its use in transmediastinal esophagectomy remains unelucidated. This study aimed to evaluate the effectiveness and safety of transhiatal chest drainage in transmediastinal esophagectomy.Methods: This retrospective study included patients who underwent transmediastinal esophagectomy for esophageal cancer from 2018 to 2021. Transhiatal chest drainage involved the insertion of a 19-Fr Blake® drain from the abdomen to the left thoracic cavity through the hiatus. We assessed its effectiveness and safety by the daily drainage output, accumulation of postoperative pleural effusion, frequency of postoperative thoracentesis, and other complications. The drainage group comprising 24 patients was compared with the non-drainage group comprising 13 patients in whom a transhiatal chest drainage tube was not placed during transmediastinal esophagectomy.Results: The median daily output of the transhiatal chest drainage was 230 mL on day 1, 385 mL on day 2, and 313 mL on day 3. The number of patients with postoperative pleural effusion was significantly reduced from 10/13 (76.9%) in the non-drainage group to 4/24 (16.7%) in the drainage group (p=0.001). The frequency of thoracentesis in the drainage group was significantly lower than that in the non-drainage group (p=0.002). There were no significant differences in the occurrence of other postoperative complications.Conclusions: Transhiatal chest drainage could evacuate pleural effusion effectively and safely after transmediastinal esophagectomy.
When SARS CoV-2 meets thyroid - short-term and long-term patients’ outcomes
Authors: Zrilić Anamarija , Režić Tanja , Majić Ana , Marušić Srećko , Berković Maja Cigrovski 
Published: June 2022

Abstract
Purpose: The interaction between thyroid and SARS CoV-2 is complex and not yet fully understood. The aim of this study was to identify a possible association of the previous thyroid disease and serum TSH level on the short-term and long-term outcomes of patients hospitalised for COVID-19.Methods: We retrospectively analysed the data of 1423 patients aged 18 years or older, with known previous thyroid status who were admitted for COVID-19 to Clinical Hospital Dubrava, Zagreb, Croatia, between March 2020 and June 2021. For 614 patients whose serum TSH was determined during hospitalisation we examined short-term outcomes, including the required level of oxygen supplementation, admission to the ICU and death. The MSCT image of the chest and TSH was recorded in the post-COVID outpatient clinic six to eight weeks after the discharge from the hospital and was used to estimate the long-term COVID-19 complications. Patients were divided into three groups according to measured TSH levels.Results: Those with lower/suppressed TSH (<0.4 mIU/L) had worse short-term outcomes and were more frequently admitted to the ICU (p<0.011), needed mechanical ventilation (p<0.001) or died (p=0.03). In the post-COVID period, there was an overall increase in the TSH levels when compared to TSH during hospitalisation. The greatest increase was detected among the patients with suppressed/lowered TSH level during hospitalisation, and it correlated significantly with MSCT finding of higher pulmonary involvement (p<0.001).Conclusion: Changes in the serum TSH level may be an important indicator for the course of COVID-19 and its long-term outcomes.
Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance
Authors: Mao Guanghua , Tang Junjie , Liao Taotao , Shi Xiaoxiang , Dong FangYuan , Feng Weiwei , Chen Yao , Zhao Ting , Wu Xiangyang , Yang Liuqing 
Published: June 2022

Abstract
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance (IR) and has attracted worldwide attention due to its high prevalence. As a typical persistent organic pollutant, decabromodiphenyl ether (BDE-209) has been detected in food and human samples and the concentration trends to increase year by year. In addition, it has been proved to have the potential to increase the risk of IR, but it is rarely reported whether it could aggravate IR in T2DM. Therefore, in this study, the IR-BRL (Buffalo Rat Liver cells with IR) model was applied to study the metabolism toxicity and susceptibility of BDE-209. Results showed that BDE-209 could inhibit the glucose absorption and increase the levels of TC and TG, ultimately lead to the disorder of glucolipid metabolism in IR-BRL cells. Besides, it also could cause cell damage by increasing the levels of AST, ALT and MDA in cells. Moreover, its potential mechanisms were to: (1) affect the transport of glucose, synthesis of glycogen and fatty acid via IRS-1/GLUT4 and IRS-1/PI3K/AKT/GSK-3β pathways; (2) impact the proliferation and differentiation by regulating the expression of Mek1/2, Erk1/2 and mTOR proteins and genes. Furthermore, susceptibility analysis showed that there was a significant synergism interaction between IR and BDE-209, which suggested that IR-BRL cells were more susceptible to the metabolism toxicity induced by BDE-209.
Retentive strength of CAD/CAM-fabricated all-ceramic crowns luted on titanium implant abutments using different ceramic materials and luting agents.
Authors: Bjelopavlovic Monika , Weyhrauch Michael , Scheller Herbert , Wentaschek Stefan , Lehmann Karl Martin 
Published: June 2022

Abstract
Objectives.
This study aimed to determine the retentive strength of monolithic hybrid-all-ceramic crowns luted on titanium implant abutments.
Material and Methods.
In total, 450 crowns (75 each of Mark II, Empress CAD, e.max CAD, Suprinity, Enamic, Celtra Duo) were milled using a CAD/CAM system. The crowns were cemented onto sandblasted titanium implant abutments using five luting agents (Multilink Implant, Variolink II, RelyX Unicem, Fujicem, and Panavia 2.0). After thermocycling, the crowns were removed using a universal testing machine. The location of luting-agent residue on the abutment and inner crown surfaces was evaluated. Analyses of variance (ANOVA) with the Bonferroni correction were performed to evaluate differences of retentive strength depending on the crown material and the kind of the luting agent.
Results.
The retentive strength for the different ceramic materials were Vita Mark II: 652N-759N (SD:134N-146N), Empress CAD: 681N-822N (SD: 89N-146N), e.max CAD: 784N-1044N (SD: 109N-176N), Vita Enamic: 716N-1177N (SD: 132N-220N), Vita Suprinity: 867N-1488N (SD: 202N-278N) and Celtra Duo 772N-1335N (SD:151N-229N). After the removal trials, the visual documentation showed different adhesive residue location depending on the ceramic materials. Furthermore, the pull-off force was dependent on the choice of adhesives
Conclusions.
The ceramic material used seems to influence the retentive strength and the use of certain luting agents result for some ceramic materials in a higher retentive strength.
The availability/use of water resources and the relationship to the behavior of the capital market
Authors: Kraizberg Elli 
Published: June 2022

Abstract
This paper is intrigued by the following question: while the relationship between water resources and economic growth is well documented, what might have a stronger significant relationship - the availability of water resources or the actual use of these resources. An interesting thirty-year experiment regarding the See of Galilei in Israel indicates that the mere availability of water rather than the actual use is a key factor the affects the capital markets. This paper found a significant relationship between the moving averages, seasonally adjusted elevation levels of the sea and the capital market, while the actual use was hardly a significant factor. Given the low quantity of actual use of the water, the findings suggest that there is likely to be another variable that indirectly and differently affects the two variables.
Immune infiltration analysis reveals immune cell signatures in human and mouse model of primary Sjögren's syndrome in salivary gland tissue
Authors: Qi Yajun , Gong Hongxiao , Qiu Xiaoting , Zhu Ling , Huo Xingxing 
Published: June 2022

Abstract
Background: The mouse model is the basis for primary Sjögren's syndrome research, but the depth of comparison between mice and humans in salivary gland immune cells is limited.Methods: Firstly, the gene expression profile of salivary glands of normal human and pSS patients was downloaded from the Gene Expression Omnibus database. The proportion of infiltrating immune cell subsets was then assessed by cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT). The experimental Sjögren's syndrome (ESS) model mice was successfully constructed using the salivary gland (SG) protein of the salivary gland, and the successful mice were screened by measuring the amount of saliva and histopathological score. Based on mouse salivary gland tissue RNA-Seq data, the seq-ImmuCC model was used to quantitatively analyze the composition ratio of 10 immune cells in salivary gland tissue from patients with primary Sjögren's syndrome and mouse models.Results: In the study, 31 human data samples were calculated and finally obtained by the CIBERSORT deconvolution method. The results of immune cell infiltration found that compared with normal human salivary gland tissue, gamma delta T cells were significantly different from naive CD4+ T cells content was significantly increased, while plasma cell content decreased. Principal component analysis (PCA) results suggested differences in immune cell infiltration between pSS patients and normal subjects. At the same time, The ESS model mice was constructed. For the mouse data analysis, we found that the proportion of macrophages increased, while the proportion of CD4+ T cells, B cells and monocytes decreased. After comprehensive analysis, we found that pSS patients and models were smaller the proportion of monocytes in salivary gland tissue of mice decreased, while the proportion of macrophages increased. The infiltration proportions of CD4+ T cells, CD8+ T cells and B cells showed a certain difference.Conclusions: Through a comprehensive analysis of salivary gland immune infiltration in patients with primary Sjögren's syndrome and model mice, we demonstrate conservation and nonconservation in the mouse and human immune systems at the level of immune cells, helping to explain the primary Regulation of immune mechanisms during the development of Sjögren's syndrome.