bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure Optimization of National Fitness Sports Big Data Platform Based on IOT Technology
Authors: Song Tao 
Published: August 2022

Abstract
With the development of the times, sports are more and more favored by people, and national fitness has become a new trend in the development of the times. In this context, to win the long-term development of sports, it must realize the integration with big data. At present, data acquisition in the sports field mainly relies on manual capture and machine intelligence recognition. However, the data capture capabilities of the two are limited and cannot provide real-time data support for the intelligent sports big data platform. The IOT is an expandable network with intelligent perception capability, which can sense and acquire sports data in time. Based on this, the article proposed a big data platform for national fitness and sports that integrated the IOT technology. It aimed to optimize the sports big data platform from the perspective of the IOT. And finally an intelligent sports big data platform was realized. The article firstly optimized the underlying structure of the sports big data platform. Then, the data acquisition strategy of the big data platform was improved by using the IOT technology, and the intelligent data acquisition was realized at the technical level. Finally, the article also optimized the structure of the intelligent resources of the sports big data platform, and initially built an intelligent sports big data platform. After data inspection and testing, the article found that the intelligent sports big data platform relying on the Internet of Things technology could further reduce the time and space complexity of data processing, and the running time was reduced by 50% year-on-year. This fully shows that the Internet of Things technology can promote the structural optimization of the sports big data platform.
Drug approval prediction based on the discrepancy between gene perturbation effects in cells and humans
Authors: Kim Sanguk , Park Minhyuk , Kim Donghyo , Kim Inhae , Im Sin-Hyeog 
Published: August 2022

Abstract
Safety failures in clinical trials increase the cost of drug development. Appropriate drug target selection with minimal toxicity is critical for successful drug development. However, the discrepancy in drug target perturbation effects between cells and humans results in safety failures of drugs with poor translatability between preclinical and clinical research. To address this issue, we developed a machine learning framework to predict the probability of drug approval in clinical trials based on the discrepancy between effects on cells/humans. We hypothesized that genes with tolerance and intolerance to perturbation effects on cells and humans, respectively, were associated with drugs having safety problems, such as drugs that failed clinical trials and were withdrawn from markets. For the first time, we demonstrated that drug approval can be predicted based on the discrepancy between gene perturbation effects in cells and humans, which explains the safety failure of drugs during preclinical to clinical translation.
Determination of 19 Fragrance Allergens in Paper Personal Care Products by Headspace SPME-GC-MS with Response Surface Methodology optimization
Authors: Chen Jing , Yi Zonghui , Yin Jiangwei , Dong Simin , Wang Lian , Li Yongxin 
Published: August 2022

Abstract
Fragrance allergens (FAs), which have unique fragrances, have been widely added in wet wipes, diapers, sanitary napkins and other paper personal care products. However, their negative effects on human health and environment cannot be ignored. Meantime, there are more than 1000 FAs, and various FAs may be added in the same product. This work presented a headspace solid phase microextraction combined with GC-MS for the analysis of 19 FAs in paper personal care products, in which the factors affecting the extraction efficiency were optimized by response surface methodology. Under optimal conditions, the performance of this method has been investigated, showing good linearity (R ≥ 0.995) in the range of 2.5×10− 4-1.28×10− 1 µg as well as good precision (RSDs ≤ 20%). The proposed method exhibited the LODs within the range of 1.9×10− 6-6.0×10− 4 µg. Twenty kinds of paper personal care products were analyzed by this method, and 12 FAs including limonene, linalool, benzyl acetate, citral, citronellol, geraniol, benzyl alcohol, phenethyl alcohol, hydroxy citronellal, cinnamaldehyde, carvacrol and isoeugenol, were detected. The detection rate of benzyl alcohol was the highest (80%) with the content from 0.009 mg/kg to 5.73 mg/kg, following by linalool (over 75%) with the content up to 12.30 mg/kg in makeup remover cleansing wipes.
Correlating theory with experimental data on the effect of symmetry on the electrocatalytic behaviour of Co phthalocyanines
Authors: Nkhahle Reitumetse , Molupe Nthabeleng , Mack John , Nyokong Tebello 
Published: August 2022

Abstract
An account on the synthesis of an asymmetric cobalt phthalocyanine, 4-((2(3),16(17),23(24)-tri-tert-butylphthalocyanine-9-yl)oxy)benzoic acid cobalt (II) (complex 1) and its symmetric counterpart, 2,9,16,23-tetra-tert-butylphthalocyanine cobalt (II) (complex 2) is provided in this work. The complexes reported were applied in the electrooxidation of hydrazine with a glassy carbon electrode serving as a support for the electrocatalysts. In comparing the two, complex 1 produced the more favourable result with a higher peak current. A further assessment on the reactivity of the complexes was carried out using theoretical calculations. Using the density functional theory method, the electronic parameters including the gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital, electrophilicity (ω), electronegativity (χ), chemical softness (S) and hardness (η) were determined. The theoretical results deemed complex 1 as the more reactive structure as it had higher values for both the electronegativity and electrophilicity. The donor-acceptor hardness (ηDA) values were also found to be in alignment with the experimental results were complex 1 produced the lower oxidation potential as it had the higher ηDA value.
Study on friction and wear properties of cast iron material in line contact condition based on free abrasive grinding experiment
Authors: Su Yongxiang , Chang Yuchong , Chen Guang , Gao Qian , Ren Chengzu 
Published: August 2022

Abstract
In order to study the friction and wear properties of cast iron in free grinding environment under the condition of line contact. This paper presented a new method to calculate the friction coefficient by measuring the friction torque. Through the self-developed free abrasive grinding experimental device in line contact condition, this work carried out friction and wear experiment with relative speed, load, abrasive particle diameter and abrasive mass fraction as process parameters, and studied the evolution rules of friction coefficient and wear amount of cast iron materials under different process parameters. Based on the response surface method Box-Behnken experimental design, the significance of the experimental results was analyzed, and the prediction model of the friction coefficient and wear amount of cast iron material was established. According to the significance of the prediction model, the influence degree of each process parameter on the friction coefficient and wear amount was revealed. The results showed that under the action of free abrasive, the friction coefficient of cast iron material in line contact with GCr15 is between 0.18 and 0.35. When the experimental time is 1.5h, the removal amount of cast iron material is between 20mg and 65mg. Which is significantly increased compared with that without abrasive and the wearing capacity of cast iron increases with the increase of relative speed, load, abrasive particle diameter and abrasive mass fraction. The friction coefficient had a negative correlation with relative speed, and a positive correlation with abrasive particle diameter and abrasive mass fraction, With the increase of load, the change of friction coefficient decreased first and then increased. The influence degree of each process parameter on the friction coefficient and wear amount of cast iron material: the particle diameter and relative velocity of abrasive were relatively significant, the abrasive mass fraction was the second, and the load was the smallest. Through random experiments, the prediction model of friction coefficient and wearing capacity were verified to be highly accuracy, and could be used to predict the friction and wear performance parameters of cast iron materials in the process of free grinding under the condition of line contact. It provided a certain theoretical basis for the friction and wear behavior of cast iron as a grinding tool material in the grinding process.
Secure secondary utilization system of genomic data using quantum secure cloud
Authors: Fujiwara Mikio , Hashimoto Hiroki , Doi Kazuaki , Kujiraoka Mamiko , Tanizawa Yoshimichi , Ishida Yusuke , Sasaki Masahide , Nagasaki Masao 
Published: August 2022

Abstract
Secure storage and secondary use of individual human genome data is increasingly important for genome research and personalized medicine. Currently, it is necessary to store whole genome sequencing information (FASTQ data) itself, which enables detections of denovo mutations and structural variations in the analysis of hereditary diseases and cancer. Furthermore, bioinformatics tools to analyze FASTQ data are frequently updated to improve the precision and recall of detected variants. However, existing secure secondary use of data, such as multi-party computation or homomorphic encryption, only can handle a limited algorithms and usually requires huge computational resources. Here, we developed a high-performance one-stop system for large-scale genome data analysis with secure secondary use of data to the data owner and multiple users with different data access control. Our quantum secure cloud system is a distributed secure genomic data analysis system (DSGD) with “a trusted server” built on a quantum secure cloud, Tokyo QKD Network under the information-theoretically secure. The trusted server will be capable of deploying and running a variety of sequencing analysis hardware, such as GPUs and FPGAs, as well as CPU-based software. We demonstrated DSGD achieved comparable throughput between with and without encryption on the “a trusted server”. Therefore, our system would be ready to be installed to the research institutes and hospitals that makes diagnoses based on whole genome sequencing on a daily basis.
Identification of two novel and four known mutation in the AAAS gene in unrelated Turkish Families
Authors: yıldırım ruken , Unal Edip , Unal Aysel , Taş Funda Feryal , Özalkak Şervan , Çayır Atilla , Özbek Mehmet Nuri 
Published: August 2022

Abstract
Aim
Triple-A Syndrome(TAS) is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia, and alacrimia. This disorder is caused by mutations in the AAAS gene. The aim of this study is to discuss the clinical, laboratory and molecular genetic analysis results of who were diagnosed with TAS.
Method
We evaluated 12 patients from 8 families. All exons and exon-intron junctions of the AAAS gene were evaluated by next generation sequencing method. Detected variants were classified according to American Collage of Medical Genetics criteria.
Results
Alacrimia was found in all of them(100%); achalasia was found in 10 patients(83.3%) and adrenal insufficiency was found in 10 patients(83.3%). In addition, hyperreflexia(6/12), learning disability(5/12), hypernasal speech(5/12), muscle weakness(8/12), delayed walking(7/12), delayed speech(6/12), excessive sweating(7/12), optic atrophy(1/12), epilepsy(1/12), palmoplantar hyperkeratosis(5/12), multiple dental caries(9/12), atrophy of the thenar/hypothenar muscles(4/12) and short stature(4/12) were detected. The DHEA-S levels were measured in 10 patients and were found to be low in 8 of them. In all patients, the sodium and potassium levels were found to be normal. Six different homozygous pathogenic variants, 2 of which had not been previously reported, were detected.
Conclusion
We detected two novel variants in the AAAS gene. The earliest sign of TAS is alacrimia. In all cases, particularly with alacrimia or achalasia, adrenal insufficiency should be investigated and if necessary, genetic analysis should be performed for TAS. Additionally, in patients diagnosed with TAS, apart from the classic triad, especially neurological dysfunction and skin and dental pathologies should be investigated and followed up with a multidisciplinary approach.
Appearance-based evaluation of varnish removal methods in gilded surfaces
Authors: Arteaga Yoko , Marchioni Diane , Courtier Stephanie , Boust Clotilde , Hardeberg Jon Y. 
Published: August 2022

Abstract
This paper outlines the use of bidirectional reflectance measurements for thecharacterisation and evaluation of appearance changes in gilded surfaces causedby varnishing and cleaning. Oil and water gilding mock-ups representative of a15th century panel painting were varnished, and a selection of four varnishcleaning methods were applied. By measuring the bidirectional reflectance of thesamples, their appearance is modelled and evaluated according to perceptualgloss attributes. Three main perceptual groups are found for each gilding type:unvarnished, varnished, and cleaned surfaces. Finally, the cleaning method mostappropriate, in terms of appearance change, for cleaning a varnished, gildedsurface is solubilisation by applying a compress.
Suppression of microRNA168 enhances salt tolerance in rice (Oryza sativa L.)
Authors: Wan Jiong , Meng Shujun , Wang Qiyue , Zhao Jiawen , Qiu Xiaoqian , Wang Liangfa , Li Juan , Mu Liqin , Dang Kuntai , Xie Qiankun , Ding Dong , Zhang Zhanhui 
Published: August 2022

Abstract
Background: Rice is a salt-sensitive crop. Complex gene regulatory cascades are likely involved in salinity stress in rice roots. microRNA168 (miR168) is a conserved miRNA among different plant species. It in-directly regulates the expression of all miRNAs by targeting gene ARGONAUTE1(AGO1). Short Tandem Target Mimic (STTM) technology is an ideal approach to study miRNA functions by in-activating mature miRNA in plants.Results: In this study, rice miR168 was inactivated by STTM. The T3 generation seedlings of STTM168 exhibited significantly enhanced salt resistance. Direct target genes of rice miR168 were obtained by in silico prediction and further confirmed by degradome-sequencing. PINHEAD (OsAGO1), which was previously suggested to be a plant abiotic stress response regulator. RNA-Seq was performed in root samples of 150mM salt-treated STTM168 and control seedlings. Among these screened 481 differentially expressed genes within STTM168 and the control, 44 abiotic stress response related genes showed significantly difference, including four known salt-responsive genes. Conclusion: Based on sequencing and qRT-PCR, a “miR168-AGO1-downstream” gene regulation model was proposed to be responsible for rice salt stress response. The present study proved miR168-AGO1 cascade to play important role in rice salinity stress responding, as well as to be applied in agronomic improvement in further.
Depressive Disorders among Adolescents During the Period from the National College Entrance Exam to Matriculation in China: The Incidence, Age at Onset, Correlates, and Service Use from Hunan Normal University Mental Health Survey
Authors: Yang Wenhui , Sun Rui , Wang Chong , Chen Jie , Zhang Chunguang , Yu Jie , Liu Haihong 
Published: August 2022

Abstract
Background: Given the serious consequences of adolescent depression and the lack of information about it during the crucially developmental period from the National College Entrance Exam (CEE) to matriculation, this study aimed to estimate the cumulative incidence, prevalence, age at onset, correlates, and service use of depressive disorders (DDs) among adolescents who passed the CEE and were enrolled at Hunan Normal University in China.Methods: A two-stage cross-sectional epidemiological survey of DDs was conducted among 6,922 incoming college students (98.5% effective response, N = 6,818, 71.4% female, age range: 16–25 years, mean age = 18.6). Based on a stratified sampling method, 926 participants were selected and subsequently interviewed using a standardized diagnostic instrument.Results: The sex-adjusted 9-month (i.e., 3 months pre-CEE, 3 months after CEE, and 3 months postmatriculation) incidence of first-onset DDs was 2.2%, and the sex-adjusted lifetime prevalence was 7.5%. The median age at onset was 17 (interquartile range: 16–18) years. Critically, over one-third (36.5%) of depressed youth had their first onset during the 9-month period. The risk factors for depression included having mothers with higher education, experiencing major life events, being female, and experiencing parental divorce or death. The lifetime treatment rate was 9.0%.Conclusion: The findings suggest a high proportion of first-onset depression during the period from the CEE to matriculation among the sample adolescents. Adolescent depression in this stage has been a public health concern. It is urgent to develop efficacious interventions to recognize and prevent adolescent depression during this critically period in Chinese youth.
Effects of extensive mobilization and tension anastomosis in anorectal reconstruction (experimental study)
Authors: Morozov Dmitrii , Morozova Olga , Severgina Lubov , Mokrushina Olga , Marchuk Tatyana , Budnik Ivan , Özbey Hüseyin , Morozov Dmitry 
Published: August 2022

Abstract
PurposeAnorectoplasty and pull-through procedure can be performed with extended mobilization or tension anastomosis, which can compromise the vasculature of the rectum. We aimed to analyze the histopathological findings, hypoxia biomarker values and to correlate the incidence of anal stenosis and defecation disorders of both conditions in experimental models. MethodsWe created anorectal reconstruction models during anorectal mobilization with extended mobilization with impaired vascularization (group I) and tension anastomosis (group II) in rats. Hypoxia biomarker values was assessed in both groups and in sham operated animals (group III). The histopathological changes on the 3rd postoperative day, anal stenosis and defecation disorders on the 35th day are compared with each other and with a control group (group IV). ResultsHypoxia biomarker levels confirmed postoperative ischemia in I – III groups compared to the control. Groups I, II are accompanied by pronounced histopathological changes in the anorectum on the 3rd postoperative day and accompanied by severe fibrosis on the 35th day. In comparison to group III, both groups showed defecation disorders and anal stenoses. ConclusionExtensive mobilization with vascular impairment and tension anastomosis resulted in similar ischemia with histopathologic changes, which in the long term resulted in fibrotic changes associated with defecation disorders.
Risk factors for periventricular–intraventricular haemorrhage severity in preterm infants: A Propensity Score-Matched Analysis
Authors: Huang Jinglan , Wang Yan , Tian Tian , Zhu Tingting , Tang Jun , Xiong Tao 
Published: August 2022

Abstract
Objectives: We investigated the risk factors besides gestational age (GA) for periventricular-intraventricular haemorrhage (PV-IVH) severity in preterm infants. Study Design: PV-IVH participants were divided into mild and severe groups and were propensity-score matched by GA. Variables were collected from infant-mother pairs.Result: A total of 3,783 preterm infants with PV-IVH were included. We matched 315 infants with severe PV-IVH with 315 with mild PV-IVH. The results suggested that sepsis (odds ratio [OR] 2.50, 95% confidence interval [CI]: 1.50–4.16), thrombocytopenia (OR 2.37, 95% CI: 1.39–4.04), multiple gestations (OR 1.69, 95% CI: 1.15–2.49), invasive mechanical ventilation (OR 1.59, 95% CI: 1.10–2.31), and magnesium sulphate use (OR 1.46, 95% CI: 1.01–2.10) were associated with severe PV-IVH. Female sex (OR 0.65, 95% CI: 0.46–0.91) was a protective factor. Conclusion: Sepsis, thrombocytopenia, multiple gestations, invasive mechanical ventilation, magnesium sulphate use, and male sex contribute to severe PV-IVH in preterm infants regardless of GA.
The impact of the COVID-19 pandemic on language deserves more attention: Evidence from university students in Greece
Authors: Loudovikou Anna , Tsagkaris Christos , Papakosta Vasiliki , Papazoglou Andreas S. , Moysidis Dimitrios V. 
Published: August 2022

Abstract
The COVID-19 pandemic has had a dire effect on young people. Recent studies have reported its impact on several mental health domains in this population group. However little has been discussed about the influence of disrupted education and socialization on the linguistic ability of young people. We report early observations from a cross - sectional study conducted among university students in Thessaloniki, Greece. Approximately 3 out of 4 participants observed foreign terms to be introduced in their everyday language, and most of them reported that they have used terms coming from at least 3 different languages. More than half of the participants agreed that the current changes to their vocabulary may have an impact ontheir future linguistic competence, and about one third of them expressed fears that nationallanguages will be negatively impacted by the situation. Nevertheless, approximately two thirds of them disagreed with the latter and opted for enhancing biology and health literacy rather than language in educational curricula. Overall, university students in Greece consider that the pandemic has diversified their vocabulary and potentially affected their linguistic competence. Integrating this knowledge in the current understanding of youth's mental health amidst COVID-19 can help researchers and healthcare practitioners meet the needs of this population group.
Whole-Genome Resequencing Reveals the Uniqueness of Subei Yak
Authors: guo shaoke , Pei Jie , Wang Xingdong , Cao Mengli , Kang Yandong , Bao Lide , Ainierlitu Ainierlitu , Zhao Shuangquan , Guo Xian 
Published: August 2022

Abstract

Background and aim: Subei yak is an essential local yak genetic resource recently discovered in the Gansu Province. Subei yak is a meat-and-milk breed with stable population genetic performance and high fecundity. However, its population structure and genetic diversity are yet to be reported. Therefore, this study aimed to identify molecular markers of Subei yak genome by whole-genome resequencing, and to analyze the population structure and genetic diversity of Subei yak.Results: This study screened 12,079,496 single nucleotide polymorphism (SNP) molecular markers in the Subei yak genome using whole-genome resequencing technology. Of these SNPs, 32.09% were located in the intronic region. The principal component analysis, phylogenetic analysis, and population structure analysis revealed that the Subei yak belonged to an independent group in the domestic yak population. The positive selection genes were annotated by comparing the Subei yak with other domestic yaks. The functional enrichment analysis showed that Subei yaks possessed prominent selection characteristics in terms of external environment perception, hypoxia adaptation, and muscle development. Further, Subei yak showed excellent muscle fat deposition and meat quality traits. Conclusions: Thus, this study will serve as a reference for discovering population structure, genetic evolution, and other unique traits of Subei yak and for expanding the genetic variation catalog of yaks.