bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of radiomics in pancreatitis: applying the evidence level rating tool for promoting clinical transferability
Authors: Zhong Jingyu , Hu Yangfan , Xing Yue , Ge Xiang , Ding Defang , Zhang Huan , Yao Weiwu 
Published: August 2022

Abstract
Background
Multiple tools have been applied to radiomics evaluation, while evidence rating tools for this field are still lacking. This study aims to assess the quality of pancreatitis radiomics research and test the feasibility of the evidence level rating tool.

Results
Thirty studies were included after a systematic search of pancreatitis radiomics studies until February 28, 2022, via five databases. Twenty-four studies employed radiomics for diagnostic purposes. The mean ± standard deviation of the adherence rate was 38.3 ± 13.3%, 61.3 ± 11.9%, and 37.1 ± 27.2% for the Radiomics Quality Score (RQS), the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) checklist, and the Image Biomarker Standardization Initiative (IBSI) guideline for preprocessing steps, respectively. The median (range) of RQS was 7.0 (− 3.0 to 18.0). The risk of bias and application concerns were mainly related to the index test according to the modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. The meta-analysis on differential diagnosis of autoimmune pancreatitis versus pancreatic cancer by CT and mass-forming pancreatitis versus pancreatic cancer by MRI showed diagnostic odds ratios (95% confidence intervals) of, respectively, 189.63 (79.65–451.48) and 135.70 (36.17–509.13), both rated as weak evidence mainly due to the insufficient sample size.

Conclusions
More research on prognosis of acute pancreatitis is encouraged. The current pancreatitis radiomics studies have insufficient quality and share common scientific disadvantages. The evidence level rating is feasible and necessary for bringing the field of radiomics from preclinical research area to clinical stage.
Protective effect of adipose-derived stromal cell-secretome attenuate autophagy induced by liver ischemia–reperfusion and partial hepatectomy
Authors: Ma Yajun , Jiao Zhihui , Liu Xiaoning , Zhang Qianzhen , Piao Chenxi , Xu Jiayuan , Wang Hongbin 
Published: August 2022

Abstract
Background
The therapeutic effects of adipose-derived mesenchymal stromal cells (ADSCs) may be mainly mediated by their paracrine effects. The ADSC-secretome can ameliorate hepatic ischemia–reperfusion injury (IRI). We explored the therapeutic effect of the ADSC-secretome from the perspective of excessive hepatocyte autophagy induced by hepatic IRI.

Methods
We established a miniature pig model of hepatic ischemia–reperfusion (I/R) and hepatectomy using a laparoscopic technique and transplanted ADSCs and the ADSC-secretome into the liver parenchyma immediately after surgery. Liver injury and hepatocyte autophagy were evaluated by histopathological examination and assessment of relevant cytokines and other factors.

Results
The results showed that the ADSC-secretome alleviated the pathological changes of liver tissue and the microstructural damage of hepatocytes after IRI. Moreover, the expression levels of autophagy-related markers including Beclin-1, ATG5, ATG12, and LC3II/LC3I decreased, whereas those of p62 increased during phagophore expansion. Furthermore, the expression levels of markers related to the autophagy inhibition pathway phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR), including PI3K, Akt, and mTOR, increased.

Conclusion
The ADSC-secretome attenuates hepatic I/R and hepatectomy-induced liver damage by inhibiting autophagy, which is possibly mediated by activation of the PI3K/Akt/mTOR signaling pathway. In addition, there was no significant difference between ADSCs and the ADSC-secretome in the regulation of hepatocyte autophagy. Therefore, ADSCs may improve the excessive autophagy-induced injury of hepatocytes in hepatic I/R and hepatectomy through paracrine effect. Our findings provide new insight into the therapeutic potential of cell-free products, which could replace cell therapy in liver diseases.
Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study
Authors: Gómez-Sánchez Leticia , Rodríguez-Sánchez Emiliano , Ramos Rafel , Marti Ruth , Gómez-Sánchez Marta , Lugones-Sánchez Cristina , Tamayo-Morales Olaya , Sánchez Susana Gonzalez , Rigo Fernando , García-Ortiz Luis , Gómez-Marcos Manuel A. ,   the MARK Investigators, Ramos Rafel , Ramos Rafel , Martí Ruth , Parramon Dídac , Ponjoan Anna , Quesada Miquel , Garcia-Gil Maria , Sidera Martina , Camós Lourdes , Montesinos Fernando , Montoya Ignacio , López Carlos , Agell Anna , Pagès Núria , Gil Irina , Maria-Castro Anna , Rigo Fernando , Frontera Guillermo , Rotger Antònia , Feuerbach Natalia , Pons Susana , Garcia Natividad , Guillaumet John , Llull Micaela , Gutierrez Mercedes , Agudo-Conde Cristina , Gómez-Sanchez Leticia , Castaño-Sanchez Carmen , Rodriguez-Martín Carmela , Sanchez-Salgado Benigna , de Cabo-Laso Angela , Gómez-Sánchez Marta , Rodriguez-Sanchez Emiliano , MaderueloFernandez Jose Angel , Ramos-Delgado Emilio , Patino-Alonso Carmen , Recio-Rod-riguez Jose I. , Gomez-Marcos Manuel A. , Garcia-Ortiz Luis 
Published: August 2022

Abstract
Background
The aim of this study was to analyze the association of physical activity and its intensity with arterial stiffness and vascular aging and differences by sex in a Spanish population with intermediate cardiovascular risk.

Methods
Cross-sectional study. A total of 2475 individuals aged 35–75 years participated in the study. Brachial–ankle pulse wave velocity (baPWV) was measured using a VaSera VS-1500® device. Based on the age and sex percentile presented by the participants, the latter were classified as follows: those with a percentile above 90 and presenting established cardiovascular disease were classified as early vascular aging (EVA); those with a percentile between 10 and 90 were classified as normal vascular aging (NVA) and those with a percentile below 10 were classified as healthy vascular aging (HVA). Physical activity was analyzed through the short version of the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ).

Results
The mean age of the participants was 61.34 ± 7.70 years, with 61.60% men. Of the total sample, 86% were sedentary (83% men vs 90% women). The total physical activity showed a negative association with baPWV (β = − 0.045; 95% CI − 0.080 to − 0.009). Intense physical activity showed a negative relationship with baPWV (β = − 0.084; 95% CI − 0.136 to − 0.032). The OR of the total physical activity and the intense physical activity carried out by the subjects classified as NVA with respect to those classified as HVA was OR = 0.946; (95% CI 0.898 to 0.997) and OR = 0.903; (95% CI 0.840 to 0.971), and of those classified as EVA it was OR = 0.916; (95% CI 0.852 to 0.986) and OR = 0.905; (95% CI 0.818 to 1.000). No association was found with moderate- or low-intensity physical activity.

Conclusions
The results of this study suggest that, when intense physical activity is performed, the probability of presenting vascular aging is lower. In the analysis by sex, this association is only observed in men.
Factors affecting the growth, antioxidant potential, and secondary metabolites production in hazel callus cultures
Authors: Hazrati Roghayyeh , Zare Nasser , Asghari-Zakaria Rasool , Sheikhzadeh Parisa , Johari-Ahar Mohammad 
Published: August 2022

AbstractHazelnut is one of the most important nut plants recently suggested as a sustainable source for paclitaxel. In the present study, the effect of the concentration and combination of PGRs, different basal medium and ultrasonic waves on callus induction and growth, physiological characteristics, and taxol and baccatin III production in hazelnut callus cultures were investigated. The results indicated that combining 2,4-D (2 mg/L) and Kin (0.2 mg/L) with the sonication of explants for 1 min provides an optimized condition for callus induction and growth. Hazelnut explants exhibited different callus production and biochemical and metabolic characteristics depending on the basal medium type, ultrasound treatment, and inclusion of ascorbic acid in the medium. So that, the highest percentage of callogenesis (100%) observed in ½ MS + 1 min US, ½ MS + 150 mg/L AA, B5 + 1 min US and B5 + 150 mg/L AA, and also ½ MS salt + Nitsch vitamins + 150 mg/L AA. Furthermore, the highest callus growth (7.86 g FW) was obtained from ½ MS + 1 min US. The highest amount of baccatin III production (147.98 and 147.85 mg/L) was obtained from the WPM and MS basal media; the highest taxol production (44.89 mg/L) was observed in the WPM basal medium. The cultures in the MS, WPM, and MS salts + Nitsch vitamins media, had the highest H2O2 and MDA content, antioxidant enzymes activity, and phenolic compounds. In conclusion, culture media nutrient composition and concentration not only affect the cell growth and physiological status of the cultures but also improve secondary metabolites production and accumulation.
Asymmetric relationships between information and communication technology (ICT), globalization, and human development in India: evidence from non-linear ARDL analysis
Authors: Behera Jayanti , Sahoo Dukhabandhu 
Published: August 2022

AbstractThe objective of the paper is to examine the asymmetric relationships between ICT, globalization, and human development in India by analysing the annual data from 1991 to 2019 through the non-linear autoregressive distributed lag (NARDL) model. The result shows that positive (negative) change in globalization leads to a decline (increase) in human development in the long run. Further, a positive change in mobile density increases human development in the long run. A decline in internet density has a negative impact on human development in the long run. In the short run, a positive shock in globalization with one lag has a positive impact on human development. Moreover, a previous year positive shock in internet density has a positive effect on human development while the previous 2 years positive shock in internet density has a negative effect on human development in the short run. A negative shock in internet density with lag one has a negative effect on human development while with lag two it has a positive effect on human development. It is also found that the global financial crisis of 2008 has a negative impact on human development. Thus, it is suggested that India has to promote both globalization and ICT judiciously and consciously in order to improve human development.
Heavy Metals in Commonly Consumed Root and Leafy Vegetables in Dhaka City, Bangladesh, and Assessment of Associated Public Health Risks
Authors: Sultana Romana , Tanvir Rahamat Ullah , Hussain Kazi Albab , Chamon Afrose Sultana , Mondol Md. Nadiruzzaman 
Published: August 2022

Abstract
Background
Excess accumulation of heavy metals in frequently consumed food (e.g., vegetables, fruits) is a serious threat to human health. The concentration of heavy metals in four root vegetables and five leafy vegetables collected from the Kawran Bazar fresh vegetable market of Dhaka, Bangladesh, were analyzed. Average daily intake (ADI), hazard quotient (HQ), and hazard index (HI) were also estimated to assess the human health risks posed by the intake of heavy metals from the consumption of the studied vegetables. Apparent differences in the concentration of heavy metals present in different vegetables were observed.

Results
The presence and degree of contamination was assessed for chromium (Cr), cadmium (Cd), lead (Pb), nickel (Ni), copper (Cu), zinc (Zn), iron (Fe), and manganese (Mn). Concentrations of Cr, Cd, Ni, and Cu exceeded the maximum permissible limit (MPL) in some root vegetables. Cr, Cd, Pb, Ni, Cu, Zn, and Fe concentration were higher in most studied leafy vegetables. ADI was found to be lower than the maximum permitted tolerable daily intake in most cases except Cr (0.202 mg/person day) and Fe (19.681 mg/person day) for the consumption of turnip and mint, respectively. Hazard quotient of Cr for turnip (1.121) and Zn for spinach (1.104), as well as the hazard indices of turnip (1.541), mustard (1.663), spinach (2.113), coriander (1.925), and mint (2.834), exceeded unit value, signifying potential health hazard from the dietary intake of the studied vegetables.

Conclusions
Higher concentrations of heavy metals were found in leafy vegetables compared to the root vegetables. Hence, the consumption of leafy vegetables has higher potential health risks than root vegetables. This study suggests that regular monitoring of heavy metals in vegetables is essential to prevent health risks associated with consuming heavy metal contaminated vegetables.
Validation of cognitive screening questionnaire for neurological disorders (CSQND) for screening of cognitive complaints among patients with multiple sclerosis
Authors: Fouad Amr , Shawky Ahmed , Farghaly Marwa , Naseer Maged Abdel , Hegazy Mohamed I. 
Published: August 2022

AbstractBackgroundThe prevalence of cognitive impairment (CI) can reach up to 65% among multiple sclerosis (MS) patients. Self-administered screening questionnaires can offer a valuable solution for screening MS patients for cognitive complaints. The cognitive screening questionnaire for neurological disorders (CSQND) is an Arabic self-administered questionnaire that has been developed to screen patients with various neurological disorders attending neurology clinics. The aim of this study was to assess cognitive complaints and to validate the CSQND as a screening tool among Egyptian MS patients.ResultsFour-hundred MS patients and 400 controls were included in this study. All 400 patients and 400 controls were subjected to the CSQND, only 50 out of the 400 patients and 50 out of the 400 controls retook the CSQND 1 week later to establish test–retest reliability. Fifty patients and 50 controls were assessed by the symbol digit modalities test (SDMT) to establish concurrent validity. Thirty-four percent of patients complained of memory problems, 51% complained of concentration difficulties, 34% complained of language difficulties and 22.5% complained of space and time disorientation. Multiple sclerosis patients had significantly more cognitive complaints (12.4 ± 12.6) compared to controls (6.2 ± 6.8) when screened using the CSQND (P < 0.000001). Total scores of CSQND were positively significantly correlated to age at onset, total disease duration, EDSS scores and total number of relapses, (r = 0.14; 0.275; 0.3; 0.167, respectively),P < 0.05 for all. Agreement was found between CSQND results and the SDMT results, where the line of equality lied within the 95% confidence interval of the mean. A significant positive correlation was found between the CSQND results at the first application and upon retesting both in patients (R = 0.9,P = 0.0001) and controls (R = 0.85,P = 0.0001).ConclusionsThe CSQND was found to be a simple, valid, and reliable self-administered questionnaire to screen for cognitive complaints in MS patients.
Etiological profile of peripheral neuropathies in an academic hospital in southern Morocco
Authors: Poda Anselm , Klevor Raymond , Salym Aouatif , Sarih Imad , Salhi Sami , Nissrine Louhab , Kissani Najib 
Published: August 2022

Abstract
Background
Peripheral neuropathies constitute a common complaint in general and neurology practice, and are a source of handicap to patients. Epidemiological data in the Middle East and North Africa region as well as in the African continent are sparse. Nevertheless, regional etiological profiles are crucial in navigating the diagnostic maze of neuropathies. This study outlines the etiological profile of peripheral neuropathies in an academic hospital in southern Morocco.

Results
A total of 180 cases were recorded in a span of 8 years (22.5 cases per year). The mean age of patients was 42.35 years. Male gender was predominant (68.88%), with a sex ratio of 2.2. Motor symptoms were the most frequently reported (86.6%). The axonal form (40.56%) was the most frequently encountered electrophysiologic form. The most frequent etiologies in the study were diabetes (26.7%), acute polyradiculoneuropathy (26.1%) and amyotrophic lateral sclerosis (16.1%). Alcohol neuropathy was found in 2.2% of the cohort. No cause was found in 5% of cases. Outcome was mostly favorable under treatment, although 10 deaths due to acute polyradiculoneuropathy were recorded (mortality = 21.3%).

Conclusions
Knowledge of the etiological profile of peripheral neuropathies should guide clinicians to an early diagnosis and aid in an adapted management of patients.
Surgical ciliated cyst of the maxillofacial region: a systematic review
Authors: Gates James C. , Taub Daniel I. , Cherkas Elliot , Tuluc Madalina , Gold Lionel 
Published: August 2022

AbstractBackgroundThe surgical ciliated cyst of the maxilla was initially reported as a sequela of Caldwell–Luc type open maxillary sinus procedures. Recently, other etiologies have become apparent and cases have been reported outside of the maxilla. They have the potential for local destruction and at times may mimic a locally aggressive tumor or cyst. We aim to elucidate the etiopathogenesis of the surgical ciliated cyst to improve prevention, diagnosis and treatment of these lesions.BodyA systematic review of the literature using PubMed and Scopus databases was conducted to assess the presentation, treatment, and outcomes of this disease. Surgical ciliated cysts of the maxillofacial region shows a 1.1:1 female-to-male ratio with a protracted time to diagnosis (range: 4–22 years). Typically, radiology shows a unilocular radiolucency (95%) and histology predominantly shows pseudostratified ciliated columnar epithelium (58%). The most common treatment of these lesions involves enucleation and curettage. In rare instances, transfacial approaches, resection, and reconstruction are required. Recurrence ranges from 6 to 20%.ConclusionSurgical ciliated cyst should be considered in a patient presenting with an orofacial mass or edema who has a history of maxillofacial injury or surgery. Timely diagnosis will decrease the severity and morbidity associated with this entity. Meticulous surgical technique can aid in the prevention of this lesion.
Hepatic resection versus microwave ablation for the treatment of early hepatocellular carcinoma: a comparative analysis of treatment outcomes and survival predictors
Authors: Osman Ayman M. A. , Abdelaziz Ashraf Omar , Deweir Mahmoud , Salah Ayman , Harb Shady Tarek Elghazaly , Nabeel Mohamed Mahmoud , Abdelmaksoud Ahmed Hosni , Shousha Hend Ibrahim , Elbaz Tamer Mahmoud , Hashem Mohamed B. 
Published: August 2022

Abstract
Introduction
Liver resection and local ablation are the two primary curative treatments for early-stage hepatocellular carcinoma (HCC). Microwave ablation (MWA) shows promising performance in terms of early tumor response, recurrence, and survival. This study aims to determine whether MWA would be comparable to liver resection in treating early-stage HCC.

Methods
This study included patients with hepatitis C-related HCC attending the multidisciplinary HCC clinic, Kasr Al-Ainy Hospital (March 2018 to September 2020). We included adults with early-stage HCC (BCLC stages 0-A). We studied patients and tumor characteristics, HCC treatment response, recurrence, and overall survival.

Results
Thirty-one patients were treated with liver resection and 41 patients were treated with MWA, including 4 patients who received intraoperative MWA. By the end of the study, 21 patients (28.77%) died. Patients who underwent MWA were younger compared to the hepatectomy group with lower baseline AFP (21 (6.7–54) versus 77 (31.3–136.0), respectively, (P value 0.024) and tumor size (2.78 (0.87) cm versus 3.77 (0.97) cm, respectively, (P value < 0.001). We found no differences between the studied groups in terms of treatment response, post-treatment decompensation, recurrence, or overall survival. One-year survival probability in the MWA and resection groups was 75.5% and 76.3% respectively. Post-procedure hepatic decompensation was the only independent predictor of lower survival by multivariate logistic regression analysis (OR 37.74, 95%CI 6.251–227.87, P value < 0.001) after adjusting for age, AFP, and tumor size.

Conclusion
Liver resection and MWA showed similar satisfactory results in the treatment of early-stage HCC, in terms of treatment response, recurrence, and overall survival.
Laser Interstitial Thermal Therapy for First-Line Treatment of Surgically Accessible Recurrent Glioblastoma: Outcomes Compared With a Surgical Cohort
Authors: Fadel Hassan A. , Haider Sameah , Pawloski Jacob A. , Zakaria Hesham M. , Macki Mohamed , Bartlett Seamus , Schultz Lonni , Robin Adam M. , Kalkanis Steven N. , Lee Ian Y. 
Published: August 2022

BACKGROUND:
Laser interstitial thermal therapy (LITT) for glioblastoma (GBM) has been reserved for poor surgical candidates and deep “inoperable” lesions. We present the first reported series of LITT for surgically accessible recurrent GBM (rGBM) that would otherwise be treated with surgical resection.

OBJECTIVE:
To evaluate the use of LITT for unifocal, lobar, first-time rGBM compared with a similar surgical cohort.

METHODS:
A retrospective institutional database was used to identify patients with unifocal, lobar, first-time rGBM who underwent LITT or resection between 2013 and 2020. Clinical and volumetric lesional characteristics were compared between cohorts. Subgroup analysis of patients with lesions ≤20 cm3 was also completed. Primary outcomes were overall survival and progression-free survival.

RESULTS:
Of the 744 patients with rGBM treated from 2013 to 2020, a LITT cohort of 17 patients were compared with 23 similar surgical patients. There were no differences in baseline characteristics, although lesions were larger in the surgical cohort (7.54 vs 4.37 cm3, P = .017). Despite differences in lesion size, both cohorts had similar extents of ablation/resection (90.7% vs 95.1%, P = .739). Overall survival (14.1 vs 13.8 months, P = .578) and progression-free survival (3.7 vs 3.3 months, P = 0. 495) were similar. LITT patients had significantly shorter hospital stays (2.2 vs 3.0 days, P = .004). Subgroup analysis of patients with lesions ≤20 cm3 showed similar outcomes, with LITT allowing for significantly shorter hospital stays.

CONCLUSION:
We found no difference in survival outcomes or morbidity between LITT and repeat surgery for surgically accessible rGBM while LITT resulted in shorter hospital stays and more efficient postoperative care.
Current advances in ischemic stroke management
Authors: Żyga Justyna 
Published: August 2022

Stroke is one of the leading causes of morbidity and mortality worldwide with 24.1 million new stroke cases in 2017 and 700,000 more stroke-related deaths, as compared to 2016. Although some patients recover after a stroke, the significant majority continue to have numerous health problems resulting in substantial decrease of life quality. This article reviews the evaluation and the current advances in the management of acute ischemic stroke, starting in the prehospital setting followed by stroke hospital management.
Conclusions: Appropriate treatment of ischemic stroke is essential in the reduction of mortality and morbidity. Therapeutic methods have greatly expanded beyond the utility of intravenous thrombolysis, with more advanced and complex techniques. Mechanical thrombectomy has revolutionised the management through the clot retrieval techniques improving patient outcomes. Appropriate application of the available treatment methods is crucial to optimising outcomes of patients with stroke, starting from pre-hospital accurate assessment. High-quality care of patients with ischemic stroke requires efficient cooperation of multidisciplinary medical staff.