bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effective And Time-Saving Three-Dimensional (3-D) Printing Protocol of Intra-Abdominal Cavity of Liver Transplantation Recipient To Prevent Large-For-Size Syndrome
Authors: Park Sunghae , Choi Gyu-Seong , Kim Jong Man , Lee Sanghoon , Joh Jae-Won , Rhu Jinsoo 
Published: February 2022

Abstract
Cost-effective and time-saving Three-dimensional (3-D) printed model of intra-abdominal cavity protocol was utilized in liver transplantation to prevent large-for-size syndrome. 3-D printings were performed on potential recipients with small cavity during July 2020 to July 2021. During deceased donor organ procurement, size of the graft was compared to the model while 3-D printed graft was physically placed into the 3-D model in living donor transplantation. Ten adults and six pediatric patients with median height and weight of 161.0 cm (IQR 158.0-163.8) and 56.5kg (IQR 49.9-62.5), and 70.0 cm (IQR 60.8-116.8) and 7.6 kg (IQR 7.0-22.0), respectively, were included. Median time and filament cost were 576 minutes (IQR 434-680) and 1.6 US dollars (IQR 1.2-1.7). Reduction graft from deceased donor (n=1), whole liver after abortion of first matched donor (n=2), whole liver from first matched donor (n=5), living donor transplantation using right liver (n=1) and left liver from living donor after abortion of first matched deceased donor (n=1) were successfully transplanted in adults. In pediatric patients, left hemiliver (n=1), reduction (n=2), and extended left lateral graft (n=3) transplantations were successfully performed. Our 3-D printed model was feasible and proved to be useful for preventing large-for-size syndrome in small recipients.
Association Between Dispensing of Low-value Oral Albuterol and Removal From Medicaid Preferred Drug Lists
Authors: Volerman Anna , Pelczar Alison , Conti Rena , Ciaccio Christina , Chua Kao-Ping 
Published: February 2022

Abstract
Background: Oral albuterol has worse efficacy and side effects compared with inhaled albuterol, and thus its use has been discouraged for decades. Drug inclusion or exclusion on formularies have been associated with reductions in low-value care. This study examines dispensing of oral albuterol and inclusion of oral albuterol on state Medicaid drug formularies--Preferred Drug Lists (PDLs). It also evaluates the association between removal of oral albuterol from the PDL and dispensing levels.Methods: This quasi-experimental study determined oral albuterol inclusion on PDLs and dispensing between 2011-2018, using Medicaid program websites and the State Drug Utilization Database. Using a difference-in-differences model, we examine the association between removal of oral albuterol from Arkansas’ Medicaid PDL in 2014 and dispensing of this drug through Medicaid, with Iowa as a control state. The outcome measure was the percent of all albuterol prescriptions that were for oral albuterol.Results: A total of 28 state Medicaid PDLs included at least one formulation of oral albuterol in 2018. In 2018, 179,446 oral albuterol prescriptions were dispensed to Medicaid beneficiaries nationally with Medicaid programs paying a total of $3.7 million for these prescriptions. Removal of oral albuterol syrup from the Arkansas PDL in March 2014 was associated with a more rapid decline in dispensing compared with Iowa. Conclusions: Findings suggest that removal of low-value medications, such as oral albuterol, from PDLs may be one avenue by which state Medicaid programs can reduce wasteful daspending while improving guideline-based care.
Coal Exit Policy Must Confront Loopholes and Laggards for Political Momentum to Matter for Paris Targets
Authors: Bi Stephen , Bauer Nico , Jewell Jessica 
Published: February 2022

Abstract
The global phase-out of coal by mid-century is considered crucial to achieving the Paris Agreement and keeping warming well-below 2°C above pre-industrial levels. Since the Powering Past Coal Alliance’s (PPCA) inception at COP23, political ambitions to accelerate coal’s decline have mounted to become the foremost priority at COP26. However, mitigation research lacks the tools to assess whether this bottom-up momentum can self-propagate toward Paris-alignment. Here, we introduce Dynamic Policy Evaluation (DPE), the first evidence-based approach for emulating real-world policymaking. Given empirical relationships established between energy-economic developments and PPCA membership, we endogenise national policy decision-making into the integrated assessment model REMIND via iterative, multi-stage feedback loops with a political feasibility model. DPE finds the PPCA ~5% likely to diffuse globally – indicative of baseline coal exit ambition – and exposes severe, unconventional risks of current power-sector-specific action. Furthermore, PPCA evolution exhibits path-dependence to Covid-19 recovery investments, illustrating DPE’s utility for exploring policy synergies.
Highly variable tRNA-Cys gene clusters in Arabidopsis thaliana
Authors: Szymanski Maciej , Maurya Anand , Karlowski Wojciech M. 
Published: February 2022

Abstract
Although most of the genes encoding tRNAs in plants are dispersed throughout the genome, a fraction of them form tRNA gene clusters. In Arabidopsis thaliana, the smallest of tRNA clusters on chromosome 5 consists of four tRNA-Cys(GCA) genes placed within repeating units of 0.4 kbp. A systematic analysis of the genomic sequences of syntenic regions from various ecotypes of A. thaliana showed that the general structure of the cluster, consisting of a tRNA-Cys pseudogene followed by repeating units containing tRNA-Cys genes, is well conserved. However, there is significant heterogeneity in the number of repeating units between different ecotypes. A unique feature of this cluster is the presence of putative transposable elements (Helitron). In addition, two further tRNA-Cys gene mini-clusters (gene pairs) in A. thaliana were identified. RNA-seq based evaluation of expression of tRNA-Cys-GCA genes showed positive signal for 11 out of 13 unique transcripts. An analysis of the conservation of the tRNA-Cys clusters from A. thaliana with the corresponding regions from four other Arabidopsis species suggests a sequence of events that led to the divergence of these regions.
The Amyloid Plaque Proteome in Early Onset Alzheimer’s Disease and Down Syndrome
Authors: Drummond Eleanor , Kavanagh Tomas , Pires Geoffrey , Ariza Mitchell Marta , Kanshin Evgeny , Nayak Shruti , Faustin Arline , Berdah Valentin , Ueberheide Beatrix , Wisniewski Thomas 
Published: February 2022

Abstract
Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies examining plaque-associated proteins have shown these additional proteins are important; they provide insight into the factors that drive amyloid plaque development and are potential biomarkers or therapeutic targets for Alzheimer’s disease (AD). The aim of this study was to comprehensively identify proteins that are enriched in amyloid plaques using unbiased proteomics in two subtypes of early onset AD: sporadic early onset AD (EOAD) and Down Syndrome (DS) with AD. We focused our study on early onset AD as the drivers of the more aggressive pathology development in these cases is unknown and it is unclear whether amyloid-plaque enriched proteins differ between subtypes of early onset AD. Amyloid plaques and neighbouring non-plaque tissue were microdissected from human brain sections using laser capture microdissection and label-free LC-MS was used to quantify the proteins present. 48 proteins were consistently enriched in amyloid plaques in EOAD and DS. Many of these proteins were more significantly enriched in amyloid plaques than Aβ. The most enriched proteins in amyloid plaques in both EOAD and DS were: COL25A1, SMOC1, MDK, NTN1, OLFML3 and HTRA1. Endosomal/lysosomal proteins were particularly highly enriched in amyloid plaques. Fluorescent immunohistochemistry was used to validate the enrichment of four proteins in amyloid plaques (moesin, ezrin, ARL8B and SMOC1) and to compare the amount of total Aβ, Aβ40, Aβ42, phosphorylated Aβ, pyroglutamate Aβ species and oligomeric species in EOAD and DS. These studies showed that phosphorylated Aβ, pyroglutamate Aβ species and SMOC1 were significantly higher in DS plaques, while oligomers were significantly higher in EOAD. Overall, we observed that amyloid plaques in EOAD and DS largely contained the same proteins, however the amount of enrichment of some proteins was different in EOAD and DS. Our study highlights the significant enrichment of many proteins in amyloid plaques, many of which may be potential therapeutic targets and/or biomarkers for AD.
Sensory Processing in Children and Adolescents Shortly After the Onset of Anorexia Nervosa: A Pilot Study
Authors: Kitajima Tasuku , Otani Ryoko , Inoue Takeshi , Matsushima Naho , Matsubara Naoki , Sakuta Ryoichi 
Published: February 2022

Abstract
BackgroundAlterations in sensory processing, such as vision, taste, and interoceptive sensation, have been reported in adult anorexia nervosa (AN). Whether these symptoms are traits, states, or “scars” due to starvation has not been fully established. Based on the hypothesis that alterations in sensory processing also occur in adolescent AN in the early stages of the disease, the present study was conducted using both self-administered and parent-administered sensory processing questionnaires.MethodsChildren and adolescents with anorexia nervosa treated at a single tertiary eating disorder treatment center in Japan (AN group) and female junior high school students attending a public junior high school in Saitama Prefecture, Japan (healthy control group: HC group) were included in the study. The Sensory Profile (SP) and Adult/Adolescent Sensory Profile (AASP) were administered to the participants and their caregivers. In addition, we collected demographic data and administered the Children's Eating Attitude Test and Autism-Spectrum Quotient Children's version.ResultsSeventeen children and adolescents were enrolled in the AN group, and 63 were enrolled in the HC group. There was no statistically significant difference between the AN and HC groups in the quadrant scores of the AASP. In the SP, the Sensory Avoidance score and the Emotional/Social response score were higher in the AN group than in the HC group.ConclusionsAlthough this study was conducted at only a single center in Japan, the results suggest that sensory processing characteristics may differ from trait symptoms. Longitudinal studies and larger-scale studies with patients in the early stages of the disease are needed.
Attacks on SQL Injection and Developing Compressive Framework Using a Hybrid and Machine Learning Approach
Authors: Deriba Fitsum Gizachew , Kassa Tsegay Mullu , Demilie Wubetu Barud 
Published: February 2022

Abstract
Web applications play an important role in everyday life. Various Web applications are used to carry out billions of online transactions. These applications are vulnerable to attacks due to their extensive use. The most prevalent attack is SQL injection, which accepts user input and runs queries in the backend based on the user's input, returning desired results. To counter the SQL injection attack, various approaches have been offered; however, the majority of them either fail to cover the full breadth of the problem. This research paper looks into frequent SQL injection attack forms, their mechanisms, and a way of identifying them based on the SQL query's existence. We propose a comprehensive framework for determining the effectiveness of techniques that address certain issues following the essence of the attack, using hybrid (Statistic and dynamic) and machine learning. An extensive examination of the model based on a test set indicates that the Hybrid and ANN approaches outperform Naive Bayes, SVM, and Decision trees in terms of accuracy in classifying injected Queries. However, when it came to web loading time during testing, Nave Bayes outperformed. The Hybrid Method improved the accuracy of SQL injection attack prevention, according to the test findings. Although we used a limited dataset for training and testing in our study, it is advised that the dataset be expanded and the model be tested in a real-world setting.
Shifts in Hydroclimatology of U.S. Croplands
Authors: Heidari Hadi 
Published: February 2022

Abstract
Changes in precipitation, temperature and water availability can significantly affect crop yields and hence food security at local and national scales. Despite the significant foreseen changes in hydroclimatology of croplands across the United States over the last decades, there are still lacking consistent information on how future hydroclimatic conditions of U.S. major croplands may change in response to climate change. This study investigates and quantifies shifts in hydroclimatology of five major crops including cotton, corn, soybean, sorghum, and wheat across the conterminous United States (CONUS). The results indicate that the direction and magnitude of hydroclimatic changes are highly variable across the climate projections. However, on average, hydroclimatic changes have a higher impact on sorghum and cotton, respectively. Understanding how croplands can be affected by climate change in the future can help decision-makers and water planners for the implementation and expansion of adaptive paths such as irrigation and conservation plans. Irrigation | Agriculture | Hydrology | Climate impacts | Crop yield
Molecular Mechanisms and Differences in Lynch Syndrome Developing into Colorectal Cancer and Endometrial Cancer Based on Gene Expression, Methylation and Mutation Analysis
Authors: Li Hongfeng , Sun Liwei , Zhuang Yan , Tian Caijuan , Yan Fang , Zhang Zhenzhen , Hu Yuanjing , Liu Pengfei 
Published: February 2022

Abstract
Purpose
The aim of this study was to screen biomarkers specific to Lynch syndrome (LS) with colorectal cancer (CRC) or endometrial cancer (EC) to explore the mechanisms by which LS develops into CRC and EC and their differences.
Methods
Differentially expressed or differentially methylated genes and differential mutations were identified in 10 LS, 50 CRC and 50 EC patients from TCGA, and genes overlapping between LS and CRC or EC (named SGs-LCs and SGs-LEs, respectively) were identified. Afterwards, we annotated the enriched GO terms and pathways and constructed a protein-protein interaction (PPI) network. Finally, samples from 10 clinical cases with MSI-H/MSS CRC and EC were collected to verify the mutations and their correlations with 5 LS pathogenic genes in the SGs-LCs and SGs-LEs.
Results
A total of 494 SGs-LCs and 104 SGs-LEs were identified and enriched in 106 and 14 GO terms, respectively. There were great differences in the gene count and enriched terms between SGs-LCs and SGs-LEs. In the PPI network, SST, GCG, SNAP25, and NPY had the highest degree of connection among the SGs-LCs, and KIF20A and NUF2 had the highest degree of connection among the SGs-LE. In the SGs-LCs and SGs-LEs, the genes whose expression levels affected the survival of LS, CRC or EC patients were quite different.
Conclusions
COL11A1 was found to be mutated in MSS CRC patients, similar to the mutations of MSH6. SST, GCG, SNAP25, and NPY may be biomarkers for the development of LS into CRC, and KIF20A and NUF2 may be markers of LS developing into EC.
Localization of salt-tolerant QTL in rice germination stage under different salinity concentrations
Authors: Wang Yanning , Song Guiting , Chen Liping , Huang Tao , Wu Guangliang , Tan Jingai , Wang Peng , Cheng Qin , Li Caijing , Zhong Qi , Huang Shiying , Yang Mengmeng , He Haohua , Bian Jianmin 
Published: February 2022

Abstract
Salt stress is an important abiotic stress, which has seriously affected the reproductive development of rice in many parts of the world. Therefore, it is particularly important to understand the genetic mechanism of salt tolerance in rice. In this study, we preliminarily located some quantitative trait loci (QTL) for root length, bud length, and survival percent under different salinity conditions (0, 100, 200 and 400 mM NaCl), using a population of chromosome segment substitution lines (CSSLs) constructed by Nipponbare and 9311. A total of 20 QTLs were identified, which explained the phenotypic variation of 4.7636%~37.5870%. There are 7, 5 and 8 QTLs for root length, bud length and survival percent, respectively. And qRL1, qSP2, qSP3, qSP4, qRL5, qSP7, qSP7-1, qSP9, qRL10, qRL10-1, qRL11, qRL11-2, qBL11, qBL11-1 and qSP12 were reported for the first time. Under different salinity conditions, the QTLs located are different, that is to say, the salt tolerance mechanism of rice under different salinity conditions may be different. The specific genetic mechanism remains to be further verified. Those QTLs identified in the experiment may be valuable genetic factors for improving salt tolerance of rice. These QTLs can be used to improve salt tolerance of rice by molecular markers technology, which will help to further understand the genetic mechanism of salt tolerance of rice.
THE ANALYSIS OF IMPLEMENTATION ACTIVITY BASED COSTING TO DETERMINING THE COST OF PRODUCTION ASSESSED IN ISLAMIC PERSPECTIVES AT PT. REKATANI DHARMA JAYA, SUMBERGEMPOL
Authors: Maulina Tika 
Published: February 2022

The research background interested that calculation of cost price production conducted by PT. Rekatani Dharma Jaya still use Traditional System. In the islamic factory also must be based on islamic to note down the financial transaction and also a honesty, so factory's worker did that conflicting of islamic law. `In this research used to quantitative approach with descriptive research. The data resource got that were secondary and premiere data. The collecting data in this research were documentation and observation. The analysis data whereas used suitable formulation by Activity Based Costing method. The result of this research are : (1) The calculation of cost price per unit production petroganic menure by traditional system as wide as 612,47, (2) The results calculation cost price petraganic menure used to Activity Based Costing 806,53, (3) The result analysis indicated that Activity Based Costing if compare the traditional method the result provides that larger with difference +194,06. (4) Activity Based Costing can applied on PT. Rekatani Dharma Jaya factory by a product, (5) The Activity Based Costing application to observe of Islamic Perspective to indicates that PT. Rekatani Dharma Jaya was conducted Activity Based Costing based on islamic perspective well.
OPTIMIZATION OF CASH FLOW MANAGEMENT DURING THE COVID-19 PANDEMIC IN THE HOME INDUSTRY OF THE FOOD AND CATERING BUSSINES IN TULUNGAGUNG REGENCY
Authors: NUR'AINI MARLILA , SUSILOWATI LANTIP 
Published: February 2022

Covid-19 Pandemic that hit Indonesia had an impact on the national economy.. The purpose of this research is to find out how home industry efforts to manage its finances in order to maintain cash flow stability so that the company can survive and thrive amid the Covid-19 pandemic. The focus of the research was on the home industry and catering bussines in Tulungagung by taking four objects as sample, they are Home Industry dry food “SUIIP”, Home Industry wet food “Nisel Gallery”, catering bussines “Awaliyah Catering”, and Home Industry “Atastyfood Tulungagung”. The method used in this research is descriptive qualitative with data collection using interview techniques, observation, and documentation. Meanwhile, the analysis technique uses an inter-incentive approach. The results of this study show that the Covid-19 pandemic has had quite an impact on the home food industry and catering bussines in Tulungagung regency. Bussines management is carried out by maintaining the circulation of capita turnover, actively inovating products, and expanding market share with online media. With these efforts, the home industry of the food and catering bussines in Tulungagung regency can maintain productivity and maintain a stable cash flow.
THE EQUITY, DIRECT MATERIALS, DIRECT LABOR, PRODUCTION COST, AND PROMOTION COST: HOW THESE CAN EFFECT TO REVENUE-SHARIA PERSPECTIVE
Authors: Putri Ristu Dwi 
Published: February 2022

Abstract: This study aims to to 1. Test the significance of the effect of capital on the business ncome of Yon Vandel Marble Craftsman. 2. Testing the significance of the nfluence of raw materials on the business ncome of Yon Vandel Marble Craftsman. 3. Testing the significance of the effect of labor wages on the business ncome of Yon Vandel Marble Craftsman. 4. Testing the significance of the effect of production on the business ncome of Yon Vandel Marble Craftsman. 5. Testing the significance of the effect of promotion costs on the business ncome of Yon Vandel Marble Craftsman. 6. To examine the significance of the effect of capital, raw materials, labor wages, production and promotion costs simultaneously on the business ncome of Yon Vandel Marble
Craftsman.This study uses a quantitative approach with the type of associative research. The sampling technique used a saturated sampling technique with a total sample of 36 quarterly financial statements of Yon Vandel Marble Craftsman 2011-2019. This study uses secondary data. The measurement scale n this study uses a ratio scale. The data analysis method used s multiple linear regression analysis. The results of this study are 1. Capital partially has a significant positive effect on the business ncome of Yon Vandel Marble Craftsmen. 2. Partial raw materials have a positive but not significant effect on the business ncome of Yon Vandel Marble Craftsman. 3. Labor wages partially have a significant positive effect on the business ncome of Yon Vandel Marble Craftsman. 4. Production partially has a positive but not significant effect on the business ncome of Yon Vandel Marble Craftsman. 5. Promotional costs partially have a positive but not significant effect on the business ncome of Yon Vandel Marble Craftsman. 6. Capital, raw materials, labor wages, production and promotion costs together have a significant positive effect on the business ncome of Yon Vandel Marble Craftsman.
Keywords: Raw Materials, Promotional Costs, Capital Income, Production, Labor Wages, Micro Enterprises
IL-10 (-819C/T), TNFA (-30G/A) and ENOS (-786T/C) Polymorphisms Modulating the Outcome Related to Mental Disorders in Crack Addicted Users
Authors: dos Santos Ana Caroline Melo , dos Santos Barbara Rayssa Correia , dos Santos Bruna Brandão , de Moura Edilson Leite , Neto Abel Barbosa Lira , Pereira e Silva Aline Cristine , de Farias Karol Fireman , de Medeiros Alves Verônica , Nardi Antônio Egídio , de Souza Figueiredo Elaine Virgínia Martins 
Published: February 2022

Background:
Cocaine/crack use affects immune system molecules and development of mental disorders has been identified.

Objective:
To investigate the relationship of polymorphisms in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes with mental disorders in cocaine and crack users.

Methods:
A case-control study was carried out, which included 107 cocaine and crack users and 115 controls who never used healthy cocaine and crack. The SNPs in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes were genotyped by real time PCR.

Results:
As for the individuals included in this study, the average age of 31.4 years (± 8.59). We identified that the G/A genotype to TNFA (-308) (OR = 0.24; p = 0.03) and the A allele (OR = 0.30; p = 0.03) were associated with reduced risk for dysthymic disorder. The T allele of the IL-10 (-819) polymorphism was associated with decreased risk of developing panic disorder (OR = 0.44; p = 0.01), while the C allele was correlated with an increased risk for alcohol dependence (OR = 1.97; p = 0.04), alcohol abuse (OR = 1.81; p = 0.04) and psychotic syndrome (OR = 2.23; p = 0.01). C/C genotype was correlated with increased chances of developing current psychotic syndrome (OR = 4.23; p = 0.01).

Conclusion:
Our results suggest that genetic polymorphisms promote susceptibility or promote protection for clinical phenotypes of psychiatric comorbidities in cocaine and crack users and be considered as good prognostic markers.