bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histories of the Unsayable: Reinhart Koselleck’s Aesthetic Anthropology
Authors: Voelz Johannes 
Published: November 2022

AbstractThis essay reviews Sediments of Time: On Possible Histories (2019), a collection of essays by the German historian and theorist of history Reinhart Koselleck (1923–2006), edited by Sean Franzel and Stefan-Ludwig Hoffmann. Written during the last three decades of Koselleck’s life and drawn from three German-language books of essays that came out in the new millennium, Sediments of Time introduces English-language readers to Koselleck’s historical anthropology—a central dimension of his oeuvre so far largely unavailable in translation. This essay argues that Koselleck’s historical anthropology is always also an aesthetic anthropology, which helps explain Koselleck’s recurring engagement with literary writers such as Shakespeare, Kleist, and Melville. At the core of Koselleck’s work lies an argument about the mutual interdependence of history and fiction. Herein resides Koselleck’s provocation for literary studies: if, for the historian, fiction provides insights into historical experience in condensed form, the reverse of this claim may engage literary scholars; for them, Koselleck suggests, the extraliterary, extralinguistic realm of historical experience is of crucial importance as a necessary condition for fiction.Koselleck’s plea to our field, committed to historicism as it is, is to return to the aesthetic in order to dive more deeply, more fundamentally into the historical.
New nitrogen-compounds, penicidones E and F, produced by the fungal strain Oidiodendron sp. FKI-7498
Authors: Miyano Rei , Matsuo Hirotaka , Mokudai Takayuki , Higo Mayuka , Nonaka Kenichi , Niwano Yoshimi , Shiomi Kazuro , Takahashi Yōko , Ōmura Satoshi , Nakashima Takuji 
Published: November 2022

ABSTRACT
The nitrogen rule in mass spectrometry was used to search for new nitrogen-compounds from microbial metabolites. During this program, two new nitrogen-containing compounds, penicidones E and F, were discovered from the filamentous fungal strain FKI-7498, which was isolated from soil collected in Tokushima, Japan, and identified as Oidiodendron sp. by sequence analysis of the internal transcribed spacer region, including 5.8S ribosomal RNA. The structures of penicidones E and F were determined by mass spectrometry, nuclear magnetic resonance spectroscopy, and chemical modification analyses. These analyses revealed that penicidones E and F have a core structure of 3,5-dihydroxy-2-(4-pyridone-3-carbonyl)benzoic acid. Penicidone E exhibited hydroxyl radical scavenging activity.
RLBind: a deep learning method to predict RNA–ligand binding sites
Authors: Wang Kaili , Zhou Renyi , Wu Yifan , Li Min 
Published: November 2022

Abstract
Identification of RNA–small molecule binding sites plays an essential role in RNA-targeted drug discovery and development. These small molecules are expected to be leading compounds to guide the development of new types of RNA-targeted therapeutics compared with regular therapeutics targeting proteins. RNAs can provide many potential drug targets with diverse structures and functions. However, up to now, only a few methods have been proposed. Predicting RNA–small molecule binding sites still remains a big challenge. New computational model is required to better extract the features and predict RNA–small molecule binding sites more accurately. In this paper, a deep learning model, RLBind, was proposed to predict RNA–small molecule binding sites from sequence-dependent and structure-dependent properties by combining global RNA sequence channel and local neighbor nucleotides channel. To our best knowledge, this research was the first to develop a convolutional neural network for RNA–small molecule binding sites prediction. Furthermore, RLBind also can be used as a potential tool when the RNA experimental tertiary structure is not available. The experimental results show that RLBind outperforms other state-of-the-art methods in predicting binding sites. Therefore, our study demonstrates that the combination of global information for full-length sequences and local information for limited local neighbor nucleotides in RNAs can improve the model’s predictive performance for binding sites prediction. All datasets and resource codes are available at https://github.com/KailiWang1/RLBind.
Time-to-event surrogate endpoint validation using mediation analysis and meta-analytic data
Authors: Le Coënt Quentin , Legrand Catherine , Rondeau Virginie 
Published: November 2022

Summary
With the ongoing development of treatments and the resulting increase in survival in oncology, clinical trials based on endpoints such as overall survival may require long follow-up periods to observe sufficient events and ensure adequate statistical power. This increase in follow-up time may compromise the feasibility of the study. The use of surrogate endpoints instead of final endpoints may be attractive for these studies. However, before a surrogate can be used in a clinical trial, it must be statistically validated. In this article, we propose an approach to validate surrogates when both the surrogate and final endpoints are censored event times. This approach is developed for meta-analytic data and uses a mediation analysis to decompose the total effect of the treatment on the final endpoint as a direct effect and an indirect effect through the surrogate. The meta-analytic nature of the data is accounted for in a joint model with random effects at the trial level. The proportion of the indirect effect over the total effect of the treatment on the final endpoint can be computed from the parameters of the model and used as a measure of surrogacy. We applied this method to investigate time-to-relapse as a surrogate endpoint for overall survival in resectable gastric cancer.
Portal vein embolization versus dual vein embolization for management of the future liver remnant in patients undergoing major hepatectomy: meta-analysis
Authors: Bell Richard J , Hakeem Abdul R , Pandanaboyana Sanjay , Davidson Brian R , Prasad Raj K , Dasari Bobby V M 
Published: November 2022

Abstract

Background
This meta-analysis aimed to compare progression to surgery, extent of liver hypertrophy, and postoperative outcomes in patients planned for major hepatectomy following either portal vein embolization (PVE) or dual vein embolization (DVE) for management of an inadequate future liver remnant (FLR).

Methods
An electronic search was performed of MEDLINE, Embase, and PubMed databases using both medical subject headings (MeSH) and truncated word searches. Articles comparing PVE with DVE up to January 2022 were included. Articles comparing sequential DVE were excluded. ORs, risk ratios, and mean difference (MD) were calculated using fixed and random-effects models for meta-analysis.

Results
Eight retrospective studies including 523 patients were included in the study. Baseline characteristics between the groups, specifically, age, sex, BMI, indication for resection, and baseline FLR (ml and per cent) were comparable. The percentage increase in hypertrophy was larger in the DVE group, 66 per cent in the DVE group versus 27 per cent in the PVE group, MD 39.07 (9.09, 69.05) (P = 0.010). Significantly fewer patients failed to progress to surgery in the DVE group than the PVE group, 13 per cent versus 25 per cent respectively OR 0.53 (0.31, 0.90) (P = 0.020). Rates of post-hepatectomy liver failure 13 per cent versus 22 per cent (P = 0.130) and major complications 20 per cent versus 28 per cent (Clavien–Dindo more than IIIa) (P = 0.280) were lower. Perioperative mortality was lower with DVE, 1 per cent versus 10 per cent (P = 0.010)

Conclusion
DVE seems to produce a greater degree of hypertrophy of the FLR than PVE alone which translates into more patients progressing to surgery. Higher quality studies are needed to confirm these results.
Implicit sensorimotor adaptation is preserved in Parkinson’s disease
Authors: Tsay Jonathan S , Najafi Tara , Schuck Lauren , Wang Tianhe , Ivry Richard B 
Published: November 2022

AbstractOur ability to enact successful goal-directed actions involves multiple learning processes. Among these processes, implicit motor adaptation ensures that the sensorimotor system remains finely tuned in response to changes in the body and environment. Whether Parkinson’s disease impacts implicit motor adaptation remains a contentious area of research: whereas multiple reports show impaired performance in this population, many others show intact performance. While there is a range of methodological differences across studies, one critical issue is that performance in many of the studies may reflect a combination of implicit adaptation and strategic re-aiming. Here, we revisited this controversy using a visuomotor task designed to isolate implicit adaptation. In two experiments, we found that adaptation in response to a wide range of visual perturbations was similar in Parkinson’s disease and matched control participants. Moreover, in a meta-analysis of previously published and unpublished work, we found that the mean effect size contrasting Parkinson’s disease and controls across 16 experiments involving over 200 participants was not significant. Together, these analyses indicate that implicit adaptation is preserved in Parkinson’s disease, offering a fresh perspective on the role of the basal ganglia in sensorimotor learning.
Right dorsolateral prefrontal cortex regulates default prosociality preference
Authors: Tanaka Hiroki , Shou Qiulu , Kiyonari Toko , Matsuda Tetsuya , Sakagami Masamichi , Takagishi Haruto 
Published: November 2022

Abstract
The dorsolateral prefrontal cortex has been shown to be associated with prosocial behavior. However, the direction of this relationship remains controversial. To resolve inconsistencies in the existing literature, we introduced the concept of default prosociality preference and hypothesized that this preference moderates the relationship between gray matter volume in the dorsolateral prefrontal cortex and prosocial behavior. This study analyzed the data of 168 participants obtained from voxel-based morphometry, 4 types of economic games, and 3 different measures of social value orientation that represent default prosociality preference. Here we show that, in individuals who were consistently classified as proself on the 3 social value orientation measures, gray matter volume in the right dorsolateral prefrontal cortex was positively associated with prosocial behavior. However, in individuals who were consistently classified as prosocial, the direction of this association was vice versa. These results indicate that the right dorsolateral prefrontal cortex regulates default prosociality preference.
Neuromodulation in the developing visual cortex after long-term monocular deprivation
Authors: Malik Anju , Eldaly Abdelrahman B M , Agadagba Stephen K , Zheng Yilin , Chen Xi , He Jufang , Chan Leanne Lai-Hang 
Published: November 2022

Abstract
Neural dynamics are altered in the primary visual cortex (V1) during critical period monocular deprivation (MD). Synchronization of neural oscillations is pertinent to physiological functioning of the brain. Previous studies have reported chronic disruption of V1 functional properties such as ocular dominance, spatial acuity, and binocular matching after long-term monocular deprivation (LTMD). However, the possible neuromodulation and neural synchrony has been less explored. Here, we investigated the difference between juvenile and adult experience-dependent plasticity in mice from intracellular calcium signals with fluorescent indicators. We also studied alterations in local field potentials power bands and phase-amplitude coupling (PAC) of specific brain oscillations. Our results showed that LTMD in juveniles causes higher neuromodulatory changes as seen by high-intensity fluorescent signals from the non-deprived eye (NDE). Meanwhile, adult mice showed a greater response from the deprived eye (DE). LTMD in juvenile mice triggered alterations in the power of delta, theta, and gamma oscillations, followed by enhancement of delta–gamma PAC in the NDE. However, LTMD in adult mice caused alterations in the power of delta oscillations and enhancement of delta–gamma PAC in the DE. These markers are intrinsic to cortical neuronal processing during LTMD and apply to a wide range of nested oscillatory markers.
Increasing Incidence of Inflammatory Bowel Disease, with Greatest Change Among the Elderly: A Nationwide Study in Finland, 2000–2020
Authors: Kontola Kristi , Oksanen Pia , Huhtala Heini , Jussila Airi 
Published: November 2022

Abstract

Background and Aims
The incidence of inflammatory bowel disease [IBD] is stabilising in many Western countries. Some still show increasing incidence. Our objective was to determine the latest trends in IBD incidence and prevalence in Finland and to compare these among different age groups and between different geographical areas.

Methods
We used the nationwide registry of the Social Insurance Institute of Finland to identify new IBD cases during the period 2000–2020. Crude, age-specific, and age-standardised incidence rates were calculated. Prevalence was estimated using valid reimbursements from the same database in 2000–2020.

Results
We identified 42 498 new IBD cases. The crude annual incidence increased in ulcerative colitis [UC] from 20 to 35 (incidence date ratio [IRR] 1.03, 95% confidence interval [CI] 1.02-1.03), in Crohn’s disease [CD] from 8 to 13 [IRR 1.02, CI 1.02-1.03] and in IBD overall from 28 to 48 per 100 000 person-years [IRR 1.02, CI 1.02-1.03]. Men had higher incidence than women in UC, but in CD the incidences were equal. The incidence of IBD increased in all age groups except for small children. The increase in both UC and CD was most marked among the elderly aged over 70. A north-south gradient was discernible. The crude prevalence of IBD increased from 376 to 972 per 100 000 (prevalence rate ratio [PRR] 1.05, CI 1.05-1.05).

Conclusions
The incidence of IBD, UC, and CD is increasing in Finland. The increase is most notable in the elderly. Current prevalence of IBD is 1%.
Applicability of European Society of Cardiology guidelines according to gross national income
Authors: van Dijk Wouter B , Schuit Ewoud , van der Graaf Rieke , Groenwold Rolf H H , Laurijssen Sara , Casadei Barbara , Roffi Marco , Abimbola Seye , de Vries Martine C , Grobbee Diederick E 
Published: November 2022

Abstract

Aims
To assess the feasibility to comply with the recommended actions of ESC guidelines on general cardiology areas in 102 countries and assess how compliance relates to the country’s income level.

Methods and results
All recommendations from seven ESC guidelines on general cardiology areas were extracted and labelled on recommended actions. A survey was sent to all 102 ESC national and affiliated cardiac societies (NCSs). Respondents were asked to score recommended actions on their availability in clinical practice on a four-point Likert scale (fully available, mostly/often available, mostly/often unavailable, fully unavailable), and select the top three barriers perceived as being responsible for limiting their national availability. Applicability was assessed overall, per World Bank gross national income (GNI) level, and per guideline.
A total of 875 guideline recommendations on general cardiology was extracted. Responses were received from 64 of 102 (62.7%) NCSs. On average, 71·6% [95% confidence interval (CI): 68.6–74.6] of the actions were fully available, 9.9% (95% CI: 8.7–11.1) mostly/often available, 6.7% (95% CI: 5.4–8.0) mostly/often unavailable, and 11·8% (95% CI: 9.5–14.1) fully unavailable. In low-income countries (LICs), substantially more actions were fully unavailable [29·4% (95% CI: 22.6–36.3)] compared with high-income countries [HICs, countries 2.4% (95% CI: 1.2–3.7); P &lt; 0.05]. Nevertheless, a proportion of actions with the lowest availability scores were often fully or mostly unavailable independent of GNIs. Actions were most often not available due to lack of reimbursement and other financial barriers.

Conclusion
Local implementation of ESC guidelines on general cardiology is high in HICs and low in LICs , being inversely correlated with country gross national incomes.
Analysis of pCl107 a large plasmid carried by an ST25Acinetobacter baumanniistrain reveals a complex evolutionary history and links to multiple antibiotic resistance and metabolic pathways
Authors: Rafei Rayane , Koong Jonathan , Osman Marwan , Al Atrouni Ahmad , Hamze Monzer , Hamidian Mehrad 
Published: November 2022

AbstractAcinetobacter baumannii has successfully spread during the last decades as one of the main critically important pathogens. However, many aspects including plasmids, are still under-investigated. Here, we report the complete sequence of an Acinetobacter baumannii strain, belonging to the ST25IP (Institut Pasteur) sequence type recovered in 2012 in Lebanon, using a combination of Illumina MiSeq and Oxford Nanopore sequencing and a hybrid assembly approach. This strain (Cl107) carries a 198 kb plasmid called pCl107 that encodes the MPFI conjugative transfer system. The plasmid carries the aacA1, aacC2, sul2, strAB, and tetA(B) antibiotic resistance genes. pCl107 region encompassing the sul2, strAB, tetA(B) is closely related to AbGRI1 chromosomal resistance islands, which are widespread in A. baumannii strains belonging to Global Clone 2. The resistance region found in pCl107 is one of the missing links in the evolutionary history of the AbGRI1 islands. pCl107 also contains a BREX Type 1 region and represents one of the two main evolution patterns observed in BREX clusters found in plasmids related to pCl107. pCl107 also harbours a ptx phosphonate metabolism module, which plays an ancestral structure compared to other large plasmids in ST25 strains. While the uric acid metabolic module found in pCl107 is incomplete, we identified possible ancestors from plasmids and chromosomes of Acinetobacter spp. Our analyses indicate a complex evolutionary history of plasmids related to pCl107 with many links to multiple antibiotic resistance and metabolic pathways.
Public Health Need, Molecular Targets, and Opportunities for the Accelerated Development of Function-Promoting Therapies: Proceedings of a National Institute on Aging Workshop
Authors: Correa-de-Araujo Rosaly , Bhasin Shalender 
Published: November 2022

Abstract

Background
People ≥ 65 years are expected to live a substantial portion of their remaining lives with a limiting physical condition and the numbers of affected individuals will increase substantially due to the growth of the population of older adults worldwide. The age-related loss of muscle mass, strength, and function is associated with an increased risk of physical disabilities, falls, loss of independence, metabolic disorders, and mortality. The development of function-promoting therapies to prevent and treat age-related skeletal muscle functional limitations is a pressing public health problem.

Methods
On March 20–22, 2022, the National Institute on Aging (NIA) held a workshop entitled “Development of Function-Promoting Therapies: Public Health Need, Molecular Targets, and Drug Development.”

Results
The workshop covered a variety of topics including advances in muscle biology, novel candidate molecules, findings from randomized trials, and challenges in the design of clinical trials and regulatory approval of function-promoting therapies. Leading academic investigators, representatives from the National Institutes of Health (NIH) and the U.S. Food and Drug Administration (FDA), professional societies, pharmaceutical industry, and patient advocacy organizations shared research findings and identified research gaps and strategies to advance the development of function-promoting therapies. A diverse audience of 397 national and international professionals attended the conference.

Conclusions
Function-promoting therapies to prevent and treat physical disabilities associated with aging and chronic diseases are a public health imperative. Appropriately powered, well-designed clinical trials and synergistic collaboration among academic experts, patients and stakeholders, the NIH and the FDA, and the pharmaceutical industry are needed to accelerate the development of function-promoting therapies.
Tectonic stress fields inferred from long-term CMT data ranging over different periods
Authors: Terakawa Toshiko , Matsu'ura Mitsuhiro 
Published: November 2022

SUMMARYWe have developed an inversion method for estimating 3-D tectonic stress fields from centroid moment tensor (CMT) data of seismic events. To obtain reliable inversion analysis results, we need to use as much data as possible, ranging over different periods. In this study, we improved the previously developed CMT data inversion method to incorporate preceding inversion analysis results into the present analysis as direct prior information about the stress field. The spatial distribution of seismic events and/or their focal mechanisms in a region would change from one period to another, reflecting temporal stress changes there. In the improved inversion method, in addition to the hyperparameter controlling the roughness of stress fields, we introduced another hyperparameter that controls the relative weight of direct prior information to the observed data to be analysed. The relative weights of direct and indirect prior information to the observed data are appropriately determined by using Akaike's Bayesian Information Criterion. We applied the improved inversion method to the observed CMT data of seismic events of 24 yr (1997−2020) in northeast Japan, where the Tohoku-oki megathrust event (Mw 9.0) occurred on 11 March 2011 at the North American–Pacific Plate boundary. To investigate temporal changes in tectonic stress orientation, we divided the target period into the inter-, pre- and post-seismic periods of the megathrust event: P1 (January 1997−January 2007), P2 (February 2007−February 2011), and P3 (March 2011−December 2020). According to successive inversion analysis results for P1 and P2, we confirmed that the tectonic stress orientation was stable for 14 yr before the megathrust event. On the other hand, successive inversion analysis results for P2 and P3 indicated a possibility that the 2011 megathrust event caused significant changes in tectonic stress orientation in three regions. However, two of them were negative in the quantitative evaluation of the reliability of detected temporal changes. In conclusion, the stress orientation change in the region off Fukushima and Ibaraki, the southern margin of the main rupture area of the megathrust event, seems to be real.