bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total neoadjuvant therapy or standard chemoradiotherapy for locally advanced rectal cancer: A systematic review and meta-analysis
Authors: Ma Zhou , Tan Ling , Liu Zi-lin , Xiao Jiang-wei 
Published: August 2022

Background and AimThe effectiveness of total neoadjuvant therapy (TNT) on patients with locally advanced rectal cancer (LARC) is controversy. This study aims to compare the prognostic value of TNT with standard neoadjuvant chemoradiotherapy (CRT) for LARC.MethodsWe searched databases (Embase [Ovid], Medline [Ovid], PubMed, Cochrane Library, and Web of Science) for articles published between January 1, 2000, and March 10, 2022. Studies on evaluating the effects of TNT and standard CRT on the prognosis of LARC were included. The primary outcomes were overall survival (OS) and disease-free survival (DFS).Results19 primary studies, involving 10 randomized controlled trials, 3 prospective studies and 6 retrospective studies, with data on 5,074 patients treated for LARC were included in the meta-analysis. Statistical analyses revealed that, compared with standard CRT, TNT significantly improved OS (hazard ratio [HR]=0.77, 95% confidence interval [CI]=0.65–0.90, I2 = 30%, P = 0.17), DFS (HR = 0.85, 95% CI = 0.74–0.97, I² = 11%, P = 0.35), distant metastases-free survival (DMFS, HR = 0.76, 95% CI = 0.65–0.90, I² = 0%, P = 0.50), pathological complete response rate (pCR, OR = 1.89, 95% CI = 1.61–2.22, I² = 0%, P = 0.47), and R0 resection rate (OR = 1.33, 95% CI = 1.07–1.67, I² = 16%, P = 0.28), but local recurrence-free survival (LRFS, HR = 1.12, 95% CI = 0.90–1.39, I² = 4%, P = 0.37).ConclusionsComprehensive literature research shows that TNT showed excellent short-term efficacy in terms of pCR and R0 resection rate while also improved the long-term outcomes of OS, DFS and DMFS, might become a new standard of treatment in patients with LARC. Even so, more studies and longer follow-up were still warranted.
Can an incomplete ERAS protocol reduce postoperative complications compared with conventional care in laparoscopic radical resection of colorectal cancer? A multicenter observational cohort and propensity score-matched analysis
Authors: Jian Chenxing , Zhou Zili , Guan Shen , Fang Jianying , Chen Jinhuang , Zhao Ning , Bao Haijun , Li Xianguo , Cheng Xukai , Zhu Wenzhong , Yang Chunkang , Shu Xiaogang 
Published: August 2022

BackgroundThe patients undergoing laparoscopic radical colorectomy in many Chinese hospitals do not achieve high compliance with the ERAS (enhanced recovery programs after surgery) protocol.MethodsThe clinical data from 1,258 patients were collected and divided into the non-ERAS and incomplete ERAS groups.ResultsA total of 1,169 patients were screened for inclusion. After propensity score-matched analysis (PSM), 464 pairs of well-matched patients were generated for comparative study. Incomplete ERAS reduced the incidence of postoperative complications (p = 0.002), both mild (6.7% vs. 10.8%, p = 0.008) and severe (3.2% vs. 6.0%, p = 0.008). Statistically, incomplete ERAS reduced indirect surgical complications (27,5.8% vs. 59, 12.7) but not local complications (19,4.1% vs. 19, 4.1%). The subgroup analysis of postoperative complications revealed that all patients benefited from the incomplete ERAS protocol regardless of sex (male, p = 0.037, 11.9% vs. 17.9%; female, p = 0.010, 5.9% vs. 14.8%) or whether neoadjuvant chemotherapy was administered (neoadjuvant chemotherapy, p = 0.015, 7.4% vs. 24.5%; no neoadjuvant chemotherapy, p = 0.018, 10.2% vs. 15.8%). Younger patients (&lt;60 year, p = 0.002, 7.6% vs. 17.5%) with a low BMI (&lt;22.84, 9.4% vs. 21.1%, p &lt; 0.001), smaller tumor size (&lt;4.0 cm, 8.1% vs. 18.1%, p = 0.004), no fundamental diseases (8.8% vs. 17.0%, p = 0.007), a low ASA score (1/2, 9.7% vs. 16.3%, p = 0.004), proximal colon tumors (ascending/transverse colon, 12.2% vs. 24.3%, p = 0.027), poor (6.1% vs. 23.7%, p = 0.012)/moderate (10.3% vs. 15.3%, p = 0.034) tumor differentiation and no preoperative neoadjuvant radiotherapy (10.3% vs. 16.9%, p = 0.004) received more benefit from the incomplete ERAS protocol.ConclusionThe incomplete ERAS protocol decreased the incidence of postoperative complications, especially among younger patients (&lt;60 year) with a low BMI (&lt;22.84), smaller tumor size (&lt;4.0 cm), no fundamental diseases, low ASA score (1/2), proximal colon tumors (ascending/transverse colon), poor/moderate differentiation and no preoperative neoadjuvant radiotherapy. ERAS should be recommended to as many patients as possible, although some will not exhibit high compliance. In the future, the core elements of ERAS need to be identified to improve the protocol.
Temporal Dynamics of Socioeconomic Inequalities in COVID-19 Outcomes Over the Course of the Pandemic—A Scoping Review
Authors: Beese Florian , Waldhauer Julia , Wollgast Lina , Pförtner Timo-Kolja , Wahrendorf Morten , Haller Sebastian , Hoebel Jens , Wachtler Benjamin 
Published: August 2022

Objectives: International evidence of socioeconomic inequalities in COVID-19 outcomes is extensive and growing, but less is known about the temporal dynamics of these inequalities over the course of the pandemic.Methods: We systematically searched the Embase and Scopus databases. Additionally, several relevant journals and the reference lists of all included articles were hand-searched. This study follows the PRISMA guidelines for scoping reviews.Results: Forty-six studies were included. Of all analyses, 91.4% showed stable or increasing socioeconomic inequalities in COVID-19 outcomes over the course of the pandemic, with socioeconomically disadvantaged populations being most affected. Furthermore, the study results showed temporal dynamics in socioeconomic inequalities in COVID-19, frequently initiated through higher COVID-19 incidence and mortality rates in better-off populations and subsequent crossover dynamics to higher rates in socioeconomically disadvantaged populations (41.9% of all analyses).Conclusion: The identified temporal dynamics of socioeconomic inequalities in COVID-19 outcomes have relevant public health implications. Socioeconomic inequalities should be monitored over time to enable the adaption of prevention and interventions according to the social particularities of specific pandemic phases.
Effect of Autochthonous Nepalese Fruits on Nutrient Degradation, Fermentation Kinetics, Total Gas Production, and Methane Production in In-Vitro Rumen Fermentation
Authors: Dhakal Rajan , Ronquillo Manuel Gonzalez , Vargas-Bello-Pérez Einar , Hansen Hanne Helene 
Published: August 2022

The objective of this study was to determine the effect of autochthonous Nepalese fruits on nutrient degradation, fermentation kinetics, total gas production, and methane production in in-vitro rumen fermentation. The fruits of Terminalia chebula (HA), Terminalia bellirica (BA), and Triphala churna (TC), a commercial mixture with equal parts (33.3% DM basis) of Phyllanthus emblica, Terminalia bellirica, and Terminalia chebula, were used. These were tested at three inclusion levels of 20% 40% and 100% of the total sample (as dry matter) in maize silage (MS). MS was used as a control (0% additive). These 10 treatments were tested for two 48-h incubations with quadruplicate samples using rumen fluid from 2 heifers. Total gas production (TGP: mL at standard temperature and pressure (STP)/g DM), methane production (expressed as % and mL/g DM), and volatile fatty acids were determined. After incubations, the filtrate was used to measure pH and volatile fatty acids (VFA), while the residue was used to measure degraded dry matter (dDM) and calculate the partitioning factor (PF48) and theoretical short-chain fatty acid concentration (tVFA). Rumen fluid pH linearly (p < 0.01) decreased in all treatments with increasing dose during fermentation. The CH4% was less in all three treatments with 100% autochthonous plants than in control, but there were no significant linear or quadratic effects for increasing BA, HA, and TC doses. The PF48 increased for all treatments with a significant linear and quadratic effect (p < 0.05) of increasing dose. Compared to MS, the inclusion of autochthonous plants increased the total volatile fatty acids, with no significant dose effects. The tVFA linearly decreased (p > 0.05) with an increasing dose of BA and HA. All treatments showed quadratic effects on tVFA (p < 0.05) with increasing dose. Increasing TC dose linearly (p < 0.05) and quadratically (p < 0.05) increased total VFA, while increasing HA dose had only a quadratic (p < 0.05) effect on total VFA. All treatments reduced total gas production (TGP) and methane concentration (CH4%) when compared to MS. The tested autochthonous fruits can be used as additives with a basal feed diet to reduce enteric methane emissions. The most effective anti-methanogenic treatment was 40% HA, which resulted in 18% methane reduction.
Rhodococcus equi-Derived Extracellular Vesicles Promoting Inflammatory Response in Macrophage through TLR2-NF-κB/MAPK Pathways
Authors: Xu Zhaokun , Hao Xiujing , Li Min , Luo Haixia 
Published: August 2022

Rhodococcus equi (R. equi) is a Gram-positive coccobacillus that causes pneumonia in foals of less than 3 months, which have the ability of replication in macrophages. The ability of R. equi persist in macrophages is dependent on the virulence plasmid pVAPA. Gram-positive extracellular vesicles (EVs) carry a variety of virulence factors and play an important role in pathogenic infection. There are few studies on R. equi-derived EVs (R. equi-EVs), and little knowledge regarding the mechanisms of how R. equi-EVs communicate with the host cell. In this study, we examine the properties of EVs produced by the virulence strain R. equi 103+ (103+-EVs) and avirulenct strain R. equi 103− (103−-EVs). We observed that 103+-EVs and 103−-EVs are similar to other Gram-positive extracellular vesicles, which range from 40 to 260 nm in diameter. The 103+-EVs or 103−-EVs could be taken up by mouse macrophage J774A.1 and cause macrophage cytotoxicity. Incubation of 103+-EVs or 103−-EVs with J774A.1 cells would result in increased expression levels of IL-1β, IL-6, and TNF-α. Moreover, the expression of TLR2, p-NF-κB, p-p38, and p-ERK were significantly increased in J774A.1 cells stimulated with R. equi-EVs. In addition, we presented that the level of inflammatory factors and expression of TLR2, p-NF-κB, p-p38, and p-ERK in J774A.1 cells showed a significant decreased when incubation with proteinase K pretreated-R. equi-EVs. Overall, our data indicate that R. equi-derived EVs are capable of mediating inflammatory responses in macrophages via TLR2-NF-κB/MAPK pathways, and R. equi-EVs proteins were responsible for TLR2-NF-κB/MAPK mediated inflammatory responses in macrophage. Our study is the first to reveal potential roles for R. equi-EVs in immune response in R. equi-host interactions and to compare the differences in macrophage inflammatory responses mediated by EVs derived from virulent strain R. equi and avirulent strain R. equi. The results of this study have improved our knowledge of the pathogenicity of R. equi.
Prediction Model for Liquid-Assisted Femtosecond Laser Micro Milling of Quartz without Taper
Authors: Yuan Hongbing , Chen Zhihao , Wu Peichao , Deng Yimin , Cao Xiaowen , Zhang Wenwu 
Published: August 2022

The strong nonlinear absorption effect and “cold” processing characteristics of femtosecond lasers make them uniquely advantageous and promising for the micro- and nanoprocessing of hard and brittle materials, such as quartz. Traditional methods for studying the effects of femtosecond laser parameters on the quality of the processed structure mainly use univariate analysis methods, which require large mounts of experiments to predict and achieve the desired experimental results. The method of design of experiments (DOE) provides a way to predict desirable experimental results through smaller experimental scales, shorter experimental periods and lower experimental costs. In this study, a DOE program was designed to investigate the effects of a serious of parameters (laser repetition frequency, pulse energy, scan speed, scan distance, scan mode, scan times and laser focus position) on the depth and roughness (Ra) of the fabricated structure through the liquid-assisted femtosecond laser processing of quartz. A prediction model between the response variables and the main parameters was defined and validated. Finally, several blind holes with a size of 50 × 50 μm2 and a depth of 200 μm were fabricated by the prediction model, which demonstrated the good consistency of the prediction model.
Pengaruh Pendidikan Kesehatan pada Pengetahuan Keluarga tentang Gejala dan Pencegahan Resiko Stroke
Authors: Pomalango Zulkifli B. , Jusuf Herlina 
Published: August 2022

Stroke merupakan penyakit yang serangannya secara tiba-tiba. Informasi melalui penyuluhan kesehatan tentang gejala stroke sangat diperlukan oleh keluarga dalam mengatasi pasien stroke di pre hospital, sehingga pasien segara mendapatkan penanganan yang tepat. Penelitian ini bertujuan untuk mengetahui pengetahuan keluarga tentang stroke, tanda, gejala serta faktor risikonya pada individu yang berisiko terkena stroke, menilai program penyuluhan kesehatan terhadap pengetahuan keluarga merawat pasien yang beresiko. Metode penelitian yakni Studi eksperimen semu, untuk menilai pengetahuan sebelum dan sesudah diberikan penyuluhan kepada keluarga yang memiliki pasien berisiko terkena stroke. Penyuluhan akan dilaksanakan secara tatap muka selama 4 menit oleh peneliti menggunakan media dan hand-out singkat. Penilaian dilakukan dengan pemberian kuesioner. Penelitian akan dilaksanakan di Wilayah Kerja Puskesmas Kota Selatan dan Puskesmas Kabila. Kegiatan ini dilaksanakn oleh 2 orang dosen, yang akan dilaksanakan selama ±2 bulan.
Hasil yang ditargetkan dalam penelitian ini yakni adanya sistem pemberdayaan keluarga dalam mengoptimalkan penanganan manajemen pre hospital pada pasien stroke, yang saat ini penelitian sudah masuk pada tindak lanjut memberikan penyuluhan kesehatan kepada keluarga yang memiliki anggota keluarga beresiko mengalami stroke. Hasi penelitian didapatkan pengetahuan keluarga tentang stroke, tanda, gejala serta faktor risikonya pada individu yang berisiko terkena stroke, menilai program penyuluhan kesehatan signifikan dapat meningkatkan pengetahuan keluarga merawat pasien yang beresiko stroke.
Sistem Informasi Manajemen Arsip Pernikahan Pada Kantor Urusan Agama
Authors: Syahroni Abd. Wahab , Subairi Imam 
Published: August 2022

INTISARIPenelitian ini bertujuan untuk mempermudah petugas Kantor Urusan Agama(KUA) bagian pengelolaan pencatatan pernikahan dalam melakukan pengarsipan data pernikahan. Saat ini, pencatatan data arsip pernikahan di KUA Kecamatan Dasuk dan Rubaru Kabupaten Sumenep masih dilakukan secara konvensional, langsung terdokumentasi pada arsip kertas sehingga petugas kesulitan dalam melakukan pencarian data pernikahan serta rekap laporan bulanan dan tahunan. Penelitian ini merancang sistem informasi manajemen arsip pernikahan KUA berbasis web, mulai dari pencatatan calon pasangan hingga pelaksanaan pernikahan akan diarsipkan kedalam aplikasi. Sehingga memudahkan dalam pencarian arsip pernikahan di masa yang akan datang. Aplikasi ini dibangun dengan menggunakan framework Codeigneiter dan MySQL sebagai basis datanya. Terdapat 4 user dalam aplikasi ini antara lain kasi kabupaten, operator kecamatan, penghulu, dan warga. Dengan adanya aplikasi ini, selain pengarsipan data pernikahan yang terdigitalisasi, warga juga dapat melihat status pernikahan orang lain. Aplikasi telah diuji dengan menggunakan metode blackbox testing dengan hasil semua fungsionalitas sistem dapat berjalan dengan baik.. Kata Kunci : KUA, Arsip Nikah, Aplikasi, Blackbox Testing. ABSTRACT This study aims to facilitate the officers of the Office of Religious Affairs (KUA) in the management of marriage records in filing marriage data. Currently, the recording of marriage archive data in KUA, Dasuk and Rubaru Subdistricts, Sumenep Regency is still done conventionally, it is directly documented on paper archives so that officers have difficulty in searching for marriage data and recapitulating monthly and annual reports.This study designed a web-based KUA marriage archive management information system, starting from the recording of the prospective spouse to the implementation of the marriage will be archived into the application. Making it easier to search for marriage archives in the future. This application is built using Codeigneiter framework and MySQL as its database. There are 4 users in this application, including the district head, sub-district operator, headman, and residents. With this application, in addition to archiving digitalized marriage data, residents can also see the marital status of others. The application has been tested using the blackbox testing method with the results of all system functionality running well. Keywords: KUA, Marriage Archives, Applications, Blackbox Testing.
Sistem Perancangan Robot Pemindah Barang Berbasis Line Follower
Authors: Yudianingsih Yudianingsih , Utari Evrita Lusiana , Mustiadi Ikhwan 
Published: August 2022

INTISARIRobot sangat berguna untuk meringankan pekerjaan manusia. Beberapa hal juga akan lebih efektif jika dikerjakan oleh robot. Penelitian ini bertujuan meringankan beban manusia dalam hal pemindahan barang. Mengingat keterbatasan manusia dan resiko yang dapat terjadi selama proses pemindahan barang. Robot pemindah barang ini menggunakan robot line follower dengan menambahkan lengan robot yang berfungsi untuk mengambil dan meletakkan kembali benda yang dipindahkan. Menggunakan modul sensor BFD-1000 yang digunakan untuk mendeteksi jalur dan mikrokontroler Arduino UNO yang digunakan sebagai pengolah perintah yang telah diberikan melalui software Arduino IDE menuju lengan robot dan driver L298N untuk menggerakkan motor.Robot pemindah barang ini dapat mengikuti jalur yang diberikan dengan baik dalam satu tujuan tanpa adanya persimpangan. Robot ini dapat memindahkan barang dari titik pengambilan barang menuju titik tujuan peletakan barang dengan berat barang kurang dari 110gr.Kata kunci— line follower, robot pemindah barang ABSTRACTIn this paper, an analysis of the value of voltage and current will be carried out on the Intensity Robots are very useful to ease human work. Some things will also be more effective if done by robots. This study aims to ease the human burden in terms of moving item. Considering human limitations and the risks that can occur during the process of moving item.This item moving robot uses a line follower robot by adding a robotic arm that functions to pick up and put back the objects being moved. Using the BFD-1000 sensor module which is used to detect the path and the Arduino UNO microcontroller which is used as a processing command that has been given through the Arduino IDE software to the robot arm and the L298N driver to drive the motor.This item moving robot can follow the given path well in one destination without any intersections. This robot can move item from the point of picking up the item to the point of placing the item with a weight of item less than 110gr.Keyword— line follower, item moving robot
Evaluasi Pelayanan Informasi Publik Melalui Situs Web Dalam Penanganan Covid-19 Di Kabupaten Mahakam Ulu
Authors: Sudiro Axel Prasetyo , Irawan Bambang , Indarto Kus 
Published: August 2022

INTISARIKeterbukaan informasi pemerintah tentunya akan mendorong keikutsertaan masyarakat publik yang merupakan suatu unsur penting dalam penerapan good governanace. Merespon hal tersebut, tujuan dari penelitian ini adalah untuk mendeskripsikan dan mengevaluasi Penerapan E-Government dalam pelayanan publik dalam bentuk situs web di Dinas Kominfo Statistik dan persandian. Penelitian ini menggunakan pendekatan penelitian deskriptif kualitatif dengan menggunakan bantuan analisis dari aplikasi bernama SortSite 5.3.5. Hasil penelitian mengungkapkan terdapat Empat Indikator dengan permasalahan anatara lain Indikator Errors dengan persentase sebanyak 15%, selanjutnya Indikator Acceseibility dengan persentase sebanyak 16%, kemudian Indikator Compatibility dengan persentase sebanyak 16% dan yang terakhir adalah Indikator Standarts pada penyusunan situs web Covid-19 Kabupaten Mahakam Ulu masih belum sepenuhnya mengikuti kaidah-kaidah yang ditetapkan oleh W3C. Kata Kunci — E-Government, Situs Web, Informasi. ABSTRACTOpenness of government information will certainly encourage the participation of the public which is an important element in the implementation of good governance. Responding to this, the purpose of this study is to describe and evaluate the application of E-Government in public services in the form of a website at the Department of Communication and Information Statistics and coding. This study uses a qualitative descriptive research approach by using analysis assistance from an application called SortSite 5.3.5. The results of the study reveal that there are four indicators with problems including the Errors Indicator with a percentage of 15%, then the Accessibility Indicator with a percentage of 16%, then the Compatibility Indicator with a percentage of 16% and the last one is the Standards Indicator in the preparation of the Covid-19 website in Mahakam Regency. Ulu still does not fully follow the rules set by the W3C.Keywords — E-Government, Website, Information.
PSYCHOLOGICAL DISTRESS, PERCEIVED SOCIAL SUPPORT, AND LIFE SATISFACTION OF FATHERS AND MOTHERS OF INTELLECTUALLY DISABLED CHILDREN
Authors: Arzeen Naeema , Irshad Erum 
Published: August 2022

OBJECTIVE: to examine psychological distress, social support, and life satisfaction of fathers and mothers of intellectually disabled children in our local setting. METHODS: This cross-sectional study was conducted from 2017 to 2019 at Department of Psychology, University of Peshawar, after approval of Advanced Studies Research Board of university. One hundred and fifty parents (75 mothers and 75 fathers) of intellectually disabled children were selected through purposive sampling technique from Peshawar, Wah Cantonment & Islamabad, Pakistan. Instruments including Depression Anxiety Stress Scale, Multidimensional Scale of Perceived Social Support, and Satisfaction with Life Scale were administered. RESULTS: Majority (n=64/150; 42.7%) of parents were aging from 20 -35 years. Seventy eight (52%) parents were from province of Khyber Pakhtunkhwa and 72 (48%) were from Punjab. Findings indicated that fathers’ mean scores were lower on depression anxiety stress scale (M=44.78; SD=14.55) as compared to mothers (M=97.32; SD=34.14). Fathers mean scores were higher on perceived social support (M=43.15; SD=9.30) than mothers (M=25.18, SD=14.36). On life satisfaction fathers means scores (M=17.36, SD=4.42) were also higher than mothers mean scores (M=9.74, SD=6.06) CONCLUSION: The study results indicated that in our cultural context fathers of the disabled children reported better perceived social support and life satisfaction while mothers experienced higher psychological distress (depression, anxiety, and stress). The role of parents in the children’s lives is concerning area because ignoring such parents’ mental health issues can triggers a lot of problems in this society.