bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-766 Birth outcomes in Anti-centromere antibody (ACA) -positive patients treated with ART
Authors: Kida Y , Tokoro M , Kitasaka H , Yoshimura T , Fukunaga N , Asada Y 
Published: June 2022

Abstract

Study question
Does the presence of the ACA have any effect on pregnancy and birth?

Summary answer
Presence of ACA did not have an impact on pregnancy and birth parameters measured.

What is known already
We have previously shown that patients with high levels of anti-centromere antibody (ACA), one of the anti-nuclear antibodies (ANA), frequently have dispersion of chromosomes in the cytoplasm. Additionally, we reported that it was characterized by a low oocyte maturation rate as observed at ovum pick up, high multiple pronuclear formation after fertilization and a low pregnancy rate after embryo transfer. Thus, the effect of ACA on fertility is clear, but the impact following pregnancy establishment has not yet been reported. Therefore, we followed up on birth outcomes in ACA-positive patients treated with ART.

Study design, size, duration
3379 patients who underwent ANA testing followed by embryo transfer between January 2014 and February 2020 and who gave birth including the results of single births with no abnormal or missing values for week and birth weight were analyzed. The subjects were classified into three groups: ANA-negative (without ACA or any other ANA), ACA-positive (with only ACA) and ANA-positive (with ANA but not ACA).

Participants/materials, setting, methods
We compared mean birth weight (full term), low weight birth infant (less than 2,500g) rate, sex ratio, congenital anomaly rate, preterm birth rate, cesarean section rate, and mean apgar score (AP) in the three groups. We treated “don't know” and “blank” for items other than week and birth weight as non-responses and missing values.

Main results and the role of chance
Of the 3379 cases for analysis, the group numbers were ANA-: 2465, ACA+: 21, ANA+: 893. The mean birth weights were 3099.6g, 3055.3g and 3088.5g respectively. In the 3 groups the rate of low birth weight infants were 8.7% (215/2465), 9.5% (2/21) and 9.2% (82/893), the sex ratio (male/female)-1.03 (1246/1212), 0.62 (8/13) and 0.93 (429/ 460), congenital anomaly rate 2.7% (67/2465), 4.8% (1/21), 3.2% (29/893), preterm birth rate 7.4% (86/2465), 4.8% (1/12), 6.7% (60/893), cesarean rate 40.0% (979/2448), 42.9% (9/21), 41.3% (367/888), and mean AP was 8.3, 8.2, and 8.3 respectively. There was no significant difference between the three groups in any of the measured items.

Limitations, reasons for caution
This study was conducted at a single institution, and only the results of those who responded to the birth survey questionnaire were analyzed. Because of the small number of patients in the ACA group, continued follow-up is considered necessary.

Wider implications of the findings
It was shown that ACA strongly affects maternal fertility, but seems to have no effect on birth parameters. However we will continue to follow up with further long-term prognostic studies.

Trial registration number
not applicable
P-770 Is there an association between blood hCG elevation rate in very early IVF pregnancy and adverse pregnancy outcomes?
Authors: Navon I , Wertheimer A , Hochberg A , Sapir O , Ben-Haroush A , Altman E , Domniz N , Shochat T , Shufaro Y 
Published: June 2022

Abstract

Study question
Is a slow elevation rate between the first and second hCG values following a successful fresh IVF cycle associated with long-term pregnancy outcomes?

Summary answer
A slow rate of hCG elevation in early IVF pregnancies is associated with an increased risk for low birth weight neonates.

What is known already
IVF pregnancies are associated with higher prevalence of late obstetrical complications such as preterm birth, preeclampsia and small for gestational age. Different baseline characteristics and treatment parameters are associated with obstetrical complications. Abnormal, mostly slow, hCG elevation patterns have been strongly associated with short-term adverse pregnancy outcomes such as non-viability, miscarriage, early fetal demise and ectopic pregnancies. However, the long-term impact of slow hCG elevation rate on pregnancies that do continue to term is unknown.

Study design, size, duration
Single center cohort study between 2008-2019 including 703 fresh cycles resulting in live singleton birth. Full obstetrical data for these pregnancies was available.

Participants/materials, setting, methods
The first blood hCG measurement was performed 14±1.4 days after ovum pick-up (OPU), and the second one 48-72h later. The slope between the two measurements was calculated and adjusted per day. Slow hCG elevation was defined as a slope value below the 10th percentile. Maternal and short-term neonatal outcomes were compared between cycles with a slow elevation (n = 71) and a “normal” elevation (n = 632) in hCG values. Multivariate analysis was used to control for potential confounders.

Main results and the role of chance
There were no differences between the slow and normal hCG elevation groups in maternal age, numbers of retrieved oocytes, ICSI rates, number of transferred and usable embryos, and gestational age at delivery. Neonates from cycles with a slow hCG elevation weighed significantly less (2876±619 gr vs. 3083±553 gr, p &lt; 0.005) and were at a higher risk (21% vs. 12%, OR = 1.96, 95% CI 1.06-3.64) of having low birth weight (LBW) (below 2500 grams). Women with slow hCG elevation rate had more hypertension-preeclampsia related complications (11% vs. 6%, p &lt; 0.05), although barely reaching statistical significance in the multivariate analysis (OR = 1.76, 95% CI 1.0-3.6).

Limitations, reasons for caution
Retrospective design, single center, applicability to fresh cycles only.

Wider implications of the findings
Very early (5th week) initial blood hCG elevation slope, measured only in IVF gestations, might be a novel marker for identifying patients at risk for hypertensive complications during pregnancy and low birth-weight neonates. Tighter prenatal care for these patients could potentially reduce pregnancy complications and improve long-term outcome.

Trial registration number
not applicable
Bayesian belief networks: a potential tool for conservation planning of endangered plant species populations
Authors: Sienkiewicz Aneta , Łaska Grażyna 
Published: June 2022

AbstractBayesian belief networks (BBNs) have been increasingly used as a potential decision supporting tool useful in conservation management. We assessed the application of the BBN model to support management in conservation planning of Pulsatilla patens (L.) Mill., the endangered plant species on a European scale, as an example. The Bayesian network approach was used to develop a model of the impact of biotic and abiotic variables on the morphological–developmental features and demographic features of the population in northeast Poland. Field data collected from the total number of 47 sites in the 4 largest forest complexes were used to develop a model using GeNIe 2.0. The diagnostic testing and sensitivity analysis indicated that the greatest impact on the population features was the number of competing species in the forest undergrowth. Validation has shown that the developed model is effective for evaluation of the impact of habitat conditions on the population features deciding about the reproduction of this taxon. The BBN model was also used to define optimal habitat conditions ensuring regular growth and development of P. patens. Finally, we demonstrated the protective treatment to help preserving the species considered. Therefore, the developed model is recommended as a potential tool to support decision-making aimed at the conservation planning of endangered plant species.
Presence and future of plant phenotyping approaches in biostimulant research and development
Authors: De Diego Nuria , Spíchal Lukáš 
Published: June 2022

Abstract
Commercial interest in biostimulants as a tool for sustainable green economics and agriculture concepts is on a steep rise, being followed by increasing demand to employ efficient scientific methods to develop new products and understand their mechanisms of action. Biostimulants represent a highly diverse group of agents derived from various natural sources. Regardless of their nutrition content and composition, they are classified by their ability to improve crop performance through enhanced nutrient use efficiency, abiotic stress tolerance, and quality of crops. Numerous reports have described modern, non-invasive sensor-based phenotyping methods in plant research. This review focuses on applying phenotyping approaches in biostimulant research and development, and maps the evolution of interaction of these two intensively growing domains. How phenotyping served to identify new biostimulants, the description of their biological activity, and the mechanism/mode of action are summarized. Special attention is dedicated to the indoor high-throughput methods using model plants suitable for biostimulant screening and developmental pipelines, and high-precision approaches used to determine biostimulant activity. The need for a complex method of testing biostimulants as multicomponent products through integrating other -omic approaches followed by advanced statistical/mathematical tools is emphasized.
The evolutionary state of the chemically peculiar members of the open cluster NGC 2516
Authors: Kharchenko N V , Piskunov A E , Hubrig S , Schöller M 
Published: June 2022

ABSTRACT
We aim at establishing safe membership and evolutionary status of 11 chemically peculiar (CP) stars that are residing in the domain of the open cluster NGC 2516 and are frequently referred to as cluster members. We queried the Gaia EDR3 catalogue in an area with a radius of 1° and selected 37 508 stars brighter than G = 19 mag. The cluster membership was determined in parallax-proper motion-space and 719 probable and 764 possible members were found. The obtained average astrometric and photometric parameters of the cluster are in good agreement with the most recent literature data. The evolutionary status of the target stars was determined with respect to Padova isochrones. After minor adjustments including the metallicity, the reddening, and the transformation scale variation, a perfect fit of the model to the observations over the whole observed magnitude range was achieved. Only 5 of the 11 considered CP stars could be classified as highly probable cluster members. Among the Ap/Bp stars with previously detected magnetic fields HD 65987 and HD 65712 have a high membership probability and the magnetic star CPD−60 944B is a possible cluster member. Further we discuss the blue straggler nature of HD 66194 and the magnetic star HD 65987. To our knowledge, HD 65987 is currently the only known blue straggler, with a field of the order of a few hundred Gauss. The most striking result of our study is that the strongly magnetic A0p star HD 66318 with previously reported very low fractional age does not belong to the NGC 2516 cluster at a high level of confidence.
The bulge masses of TDE host galaxies and their scaling with black hole mass
Authors: Ramsden Paige , Lanning Daniel , Nicholl Matt , McGee Sean L 
Published: June 2022

ABSTRACT
Tidal disruption events (TDEs) provide a means to probe the low end of the supermassive black hole (SMBH) mass distribution, as they are only observable below the Hills mass (≲ 108 M⊙). Here, we attempt to calibrate the scaling of SMBH mass with host galaxy bulge mass, enabling SMBH masses to be estimated for large TDE samples without the need for follow-up observations or extrapolations of relations based on high-mass samples. We derive host galaxy masses using prospector fits to the UV-MIR spectral energy distributions for the hosts of 29 well-observed TDEs with BH mass estimates from mosfit. We then conduct detailed bulge/disc decomposition using SDSS and PanSTARRS imaging, and provide a catalogue of bulge masses. We measure a positive correlation between SMBH and bulge mass for the TDE sample, with a power-law slope of 0.28 and significance p = 0.06 (Spearmans) and p = 0.05 (Pearsons), and an intrinsic scatter of 0.2 dex. Applying MC resampling and bootstrapping, we find a more conservative estimate of the slope is 0.18 ± 0.11, dominated by the systematic errors from prospector and mosfit. This is shallower than the slope at high SMBH mass, which may be due to a bias in the TDE sample towards lower mass BHs that can more easily disrupt low-mass stars outside of the event horizon. When combining the TDE sample with that of the high-mass regime, we find that TDEs are successful in extending the SMBH – stellar mass relationship further down the mass spectrum and provide a relationship across the full range of SMBH masses.
New Deal, New Patriots: How 1930s Government Spending Boosted Patriotism During World War II
Authors: Caprettini Bruno , Voth Hans-Joachim 
Published: June 2022

AbstractWe demonstrate an important complementarity between patriotism and public-good provision. After 1933, the New Deal led to an unprecedented expansion of the U.S. federal government’s role. Those who benefited from social spending were markedly more patriotic during World War II: they bought more war bonds, volunteered more, and, as soldiers, won more medals. This pattern was new—World War I volunteering did not show the same geography of patriotism. We match military service records with the 1940 census to show that this pattern holds at the individual level. Using geographical variation, we exploit two instruments to suggest that the effect is causal: droughts and congressional committee representation predict more New Deal agricultural support, as well as bond buying, volunteering, and medals.
Developmental trajectories of toddler sleep problems: can a person-centered approach help identify children at risk?
Authors: Gustafsson Hanna C , Propper Cathi B 
Published: June 2022

AbstractStudy ObjectivesPrevious research examining toddler sleep problems has relied almost exclusively on variable-centered statistical approaches to analyze these data, which provide helpful information about the development of the average child. The current study examined whether person-centered trajectory analysis, a statistical technique that can identify subgroups of children who differ in their initial level and/or trajectory of sleep problems, has the potential to inform our understanding of toddler sleep problems and their development.MethodsFamilies (N = 185) were assessed at 12, 24, 30, and 36 months of child age. Latent class growth analysis was used to test for subgroups that differed in their 24–36 month sleep problems. Subgroups were compared on child 36-month externalizing, internalizing, and total problem behaviors, and on 12 month maternal mental health, inter-parental conflict, and maternal parenting behaviors.ResultsResults support a four-class solution, with “low, stable,” “low, increasing,” “high, increasing,” and “high decreasing” classes. The classes whose sleep problems persisted or worsened over time had worse behavioral problems than those whose symptoms improved or remained stably low. Additionally, 12 month maternal depression and global symptom severity, intimate partner violence, and maternal harsh-intrusive parenting behaviors discriminated between the classes that had similar levels of 24 month sleep disturbance but who had diverging trajectories over time.ConclusionsThis statistical approach appears to have the potential to increase understanding of sleep problem trajectories in the early years of life. Maternal mental health, intimate partner violence, and parenting behaviors may be clinically useful markers of risk for the persistence or development of toddler sleep problems.
Indigenous Access to Social Assistance and Identity: A Gendered Relational Reading of Settler Colonial Containment inShubenacadie Indian Band v. Canada
Authors: Hall Rebecca Jane , Vosko Leah F , Coburn Veldon 
Published: June 2022

AbstractIn Canada, the settler colonial state uses the regulation of the so-called Indian identity as a dispossessive strategy, a racialized and gendered means of controlling access to resources and attempting to contain Indigenous human, nonhuman, and land-based relations. This regulation is informed by Western patriarchal ideals and mechanisms. We examine settler accounts of “Indian” identity and their effects through a gendered reading of Shubenacadie Indian Band v. Canada, a legal case centering on the provision of social assistance. Our critique is grounded in a relational approach to Indigenous self-recognition, an approach that transcends the false dichotomy between individual (women’s) rights and group (cultural) rights, critiqued by Joyce Green. This case exemplifies individualized approaches to identity that obscure the relational practices seeking to retain, reproduce, and revitalize Indigenous modes of life, an ongoing terrain of de/colonizing struggle.
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats
Authors: Yamada Takanori , Toyoda Takeshi , Matsushita Kohei , Akane Hirotoshi , Morikawa Tomomi , Cho Young-Man , Ogawa Kumiko 
Published: June 2022

Abstract
We investigated γ-H2AX formation, a biomarker of DNA damage, and expression of stem cell markers (SCMs), including cytokeratin 14, aldehyde dehydrogenase 1A1 (ALDH1A1), and CD44, in the development of rat bladder tumors induced by short-term administration of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Histopathological examination showed that diffuse simple hyperplasia of the bladder urothelium induced by BBN recovered to the normal-appearing urothelium after withdrawal, whereas focal proliferative lesions were newly developed and subsequently progressed to benign papilloma and carcinoma. Immunohistochemical analysis revealed that BBN-induced γ-H2AX formation and ALDH1A1 and CD44 expression persisted at higher levels in the normal-appearing urothelium than those in the control group for long periods after withdrawal. Since persistent chronic inflammation was observed even after withdrawal, targeted gene expression analysis of inflammation-related factors revealed 101 genes, including Stat3 and Myc, that showed persistent high expression. Pathway analysis suggested that Stat3 and/or Myc activation may be associated with SCM expression. We focused on hepatocyte growth factor (Hgf), one of the genes predicted in relation to Stat3/Myc, and confirmed that HGF-positive cells increased by BBN persisted in the normal-appearing urothelium after withdrawal and colocalized with γ-H2AX and SCMs. These results suggested that the long-term persistence of γ-H2AX formation and SCM expression, which occurred during the early stages of bladder tumorigenesis, is not a transient response to exposure and might contribute to bladder tumorigenesis. Although further studies are needed, BBN-induced rat bladder tumors may originate from focal hyperplasia arising from SCM-positive cells via activation of the STAT3/MYC pathway after DNA damage involving γ-H2AX formation.
Transconjunctival XEN45 Implantation for Glaucoma Performed at the Slit Lamp: A Pilot Study
Authors: Gagné Sébastien , Yuen Darana , Cohen Shawn 
Published: June 2022

Précis:
The ab externo implantation of a gel microstent is a novel, minimally invasive glaucoma surgery performed at the slit lamp that is effective for lowering intraocular pressure in patients with uncontrolled glaucoma.

Purpose:
To evaluate the intraocular pressure (IOP) -lowering effect of gel microstent (XEN® Gel Stent, Allergan, Irvine, CA) implantation using an ab externo approach in an office setting.

Patients and Methods:
This retrospective, multicenter chart review examined outcomes in patients with uncontrolled glaucoma receiving maximally tolerated medical therapy, who underwent slit lamp ab externo gel stent implantation. Postoperative IOP, the number of glaucoma medications, the final position of the stent and the needling rate were analyzed. Assessments occurred 1 day, 1 week and 1, 3, 6 and 12 months after implantation. Treatment success was defined as IOP ≥6 mmHg and ≤18 mmHg with ≥20% reduction from presurgical IOP, with or without medications.

Results:
Thirty-four (34) eyes from 28 patients were included. Mean preoperative IOP was 24.1±8.0 mmHg on 3.2±0.9 glaucoma medications. At 12 months postoperative, IOP was reduced to 15.4±4.7 mmHg on 0.6±1.0 medications; 46.9% and 81.3% of eyes achieved complete and partial success, respectively. The gel stent was properly positioned in 94.1% of eyes after one attempt at implantation and in 100% of eyes after a second attempt. In addition to malpositioning, observed complications included occlusion, erosion, and endophthalmitis following anterior chamber (AC) reformation. Adjunctive needling was required in 21% of implanted eyes.

Conclusion:
Slit-lamp-based transconjonctival XEN45 implantation reduced intraocular pressure in glaucoma patients in the first year of this pilot study and was most commonly associated with wound leak and hypotonic among other adverse events.
The feasibility of multimodality remote monitoring of maternal physiology during pregnancy
Authors: Zielinska Agata P. , Mullins Edward , Lees Christoph 
Published: June 2022

Gestational hypertension affects 10% of pregnancies, may occur without warning, and has wide-ranging effects on maternal, fetal, and infant health. Antenatal care largely relies on in-person appointments; hence, only <4% of the pregnancy period is subject to routine clinical monitoring. Home monitoring offers a unique opportunity to collect granular data and identify trends in maternal physiology that could predict pregnancy compromise. Our objective was to investigate the feasibility of remote multidomain monitoring of maternal cardiovascular health both in and after pregnancy.
This was a prospective feasibility study of continuous remote monitoring of multiple modalities indicative of cardiovascular health from the first trimester to 6 weeks postpartum.
Twenty-four pregnant women were asked to monitor body weight, heart rate, blood pressure, activity levels, and sleep patterns daily. Study participants took on average 4.3 (standard deviation [SD] = 2.20) home recordings of each modality per week across the 3 trimesters and 2.0 postpartum (SD = 2.41), out of a recommended maximum of 7. Participant retention was 58.3%. Wearing a smartwatch daily was reported as feasible (8.6/10, SD = 2.3) and data could be entered digitally with ease (7.7/10, SD = 2.4).
Remote digital monitoring of cardiovascular health is feasible for research purposes and hence potentially so for routine clinical care throughout and after pregnancy. Fifty-eight percent of women completed the study. Multiple modalities indicative of cardiovascular health can be measured in parallel, giving a global view that is representative of the whole pregnancy period in a way that current antenatal care is not.

Condensed abstract:
To ascertain whether remote multimodality cardiovascular monitoring of health in pregnancy is feasible, 24 participants were asked to daily monitor body weight, heart rate, blood pressure, activity levels, and sleep patterns. Study participants took on average 4.3 (standard deviation = 2.20) home recordings of each modality per week across the 3 trimesters and 2.0 postpartum (standard deviation = 2.41), out of a recommended maximum of 7. Thus, remote monitoring indicative of cardiovascular health throughout and after pregnancy might be feasible for routine clinical care or within the context of a research study.