bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior petrosal (Kawase) approach to petroclival meningioma: 2-dimensional operative video
Authors: Wu Eva M. , Altshuler David , Chen Stephanie H. , Morcos Jacques J. 
Published: April 2022

Petroclival meningiomas are challenging lesions that can be treated with several surgical approaches. The authors present a 66-year-old woman with a 1.6-cm left petroclival meningioma that was initially observed and then radiated after it grew 8 years later. Despite radiation, the tumor continued to grow to 4 cm; therefore, the patient was referred to the authors’ institution. A left anterior petrosal (Kawase) approach was performed. Postoperatively, the patient had transient cranial nerve IV and VI palsy that improved. The case presentation, surgical anatomy, operative technique, postoperative course, and different surgical approaches are reviewed. The patient gave verbal consent for participating in the surgical video.
The video can be found here: https://stream.cadmore.media/r10.3171/2022.1.FOCVID21259
Martha the Hostess and Mary the Listener. A Dialogue with two Feminist Interpretations of Luke 10:38-42
Authors: Crimella Matteo 
Published: April 2022

This article examines the pericope of Lk 10:38-42 through the lens of gender. It presents the specific contributions of E. Schüssler Fiorenza and also M. Perroni, both of whom have interpreted the passage according to a feminist approach. The former has developed some hermeneutical criteria while the latter has insisted on female discipleship, claiming that, for Luke, the women are believers but not missionaries. The present article turns critically on the essential points of the two commentators, showing that a careful philological and contextual analysis does not allow the episode to be read as a representation of ministry in the Church. Instead, Mary’s behaviour of placing herself at the Lord’s feet appears alienating, an action which is both surprising and contrary to the social canons. The episode lays stress on precisely this difference, showing that the two poles are not "service" and "listening" but rather "distracting preoccupations" versus a "disciple’s attitude". The behaviour of the two sisters thus functions as a mirror by which the reader is invited to discern different attitudes towards Jesus.
Analysis of Educational Values in Tere Liye's �Hujan� Novel as Literary Teaching Materials in High School
Authors: Rakhmanina Lisa , Melati Melati , Haimah Haimah 
Published: April 2022

Abstract
The objective of this research was to gain a deep understanding of the educational values in Tere Liye's novel, Hujan. This novel, Hujan, served as the basis for the research. The novel's educational values served as the research's data. The research method was descriptive qualitative. According to the study, Tere Liye's novel Hujan reflects educational values for his readers in the following ways: first, the moral value of education: always help, perseverance, and responsibility. Second, there is the value of social education in terms of humanity, caring, and empathy. Third, there is the value of cultural education in terms of mutual cooperation, obedient rules, and mutual respect. Tere Liye's Hujan was suggested as an alternative to literary teaching materials in high school.
Publication Trends in Surgical Treatment of Distal Radius Giant Cell Tumors Over the Past Five Years
Authors: Idulhaq Mujaddid , Utomo Pamudji , Adriansyah Denny 
Published: April 2022

Background: Surgical interventions such as intralesional curettage until the complete excision and reconstruction require distal radius GCT treatment. However, to maintain the wrist function and reduce recurrent tendency, a more comprehensive understanding is needed to decide on the best therapeutic option as the standard strategy to achieve complete resection and functional outcomes. Therefore, this study aims to find the current treatment trends based on a literature study on distal radius GCT, emphasizing their potential outcomes. Methods: The search strategy using the PubMed search engine (https://pubmed.ncbi.nlm.nih. gov/) was conducted on September 21, 2020, with the keywords: “distal radius giant cell tumor”. The search resulted in 261 articles, and they were filtered by “published in the last five years,” which yielded 67 articles. These articles then underwent further screening, resulting in 40 articles for the analysis. Results: For article types, there were 27% (11/40) prospective studies, 32% (13/40) retrospective studies, 5% (2/40) systematic reviews, 27% (11/40) case reports, and 5% (2/40) case series. For the case series, more than ten cases were reported in both articles. There were 47 treatments in those total articles, and there were two types of GCT excision: intralesional curettage (extended and non-extended) (74.4%; 35/47) and en bloc (wide) resection (25.5%; 12/47). Conclusions: The total number of articles published in the last five years on the distal radius increased in 2020. Most types of articles were retrospective studies, followed by case reports and prospective studies. The most common treatment published in the last five years is intralesional curettage than en bloc resection, with excellent results in intralesional curettage’s functional outcome.
Dispositivos musicais na reabilitação neurológica no membro superior: uma revisão integrativa
Authors: Moniz Yasmim Fernandes , Silva Alessandro Pereira da , Gunji Bruno Toshio Gomes , Scardovelli Terigi Augusto , Martini Silvia Cristina , Boschi Silvia Regina Matos da Silva 
Published: April 2022

Introdução: A reabilitação neurológica do membro superior é um processo desafiador que exige alta adesão do paciente para resultados efetivos. Uma das estratégias para promover a neuroplastidade e a motivação dos pacientes é a utilização de música na reabilitação. Os progressos nesta área motivaram a criação de dispositivos/jogos musicais que visam a reabilitação de forma lúdica, funcional e menos fatigante. Objetivos: Sintetizar e analisar por meio de uma revisão integrativa os benefícios, usabilidade, limitações e possíveis aprimoramentos dos dispositivos musicais aplicados a reabilitação neurológica. Metodologia: A busca dos artigos foi realizada nas bases de dados PubMed, Scielo, PeDro e Cochrane Library. Utilizou-se os seguintes descritores: “Music Intervention”, “Rehabilitation”, “Music Device”, “Neurologic Disease”, “Upper Limb”, associados aos boleanos “and” e “or” sendo os descritores indicados no título ou no resumo do artigo. Foram admitidos artigos publicados nos últimos 10 anos e sem restrição de idioma. Resultados: Foram encontrados 5 artigos que satisfaziam os critérios de inclusão. Os dispositivos foram desenvolvidos para pacientes com Acidente Vascular Encefálico e Doença de Parkinson. Os principais benefícios foram: aumento da repetição das tarefas, melhora nas habilidades rítmicas, aumento coerência da fase cortiço muscular, aumento da motivação do voluntário e melhora na suavidade dos movimentos. Conclusão: A utilização de dispositivos musicais na reabilitação neurológica do membro superior se mostrou benéfica, viável e sem riscos aparentes. Ainda há um número escasso de artigos, principalmente ensaios clínicos randomizados, além de amostras não tão representativas, são necessários mais estudos para validar a utilização destes dispositivos.
Pro-Angiogenesis Role of LINC00662 From Esophageal Squamous Cell Carcinoma Cells-Derived Extracellular Vehicles
Authors: Li Feng , Niu Ren , Gao ShaoLin , Zhao FangChao , Dong Zefang , Zhang Hao , Li Shujun 
Published: April 2022

Objective: LINC00662 is oncogenic in some human cancers, but no much was revealed concerning to its specific action in tumor angiogenesis. Given that, our study investigated the role of LINC00662 from esophageal squamous cell carcinoma (ESCC) cells-derived extracellular vehicles (EVs) in angiogenesis through microRNA (miR)-195-5p/vascular endothelial growth factor A (VEGFA) axis.Methods: Clinical tissue samples were collected from patients with ESCC, in which LINC00662, miR-195-5p and VEGFA expression was analyzed. ESCC cells were transfected, from which EVs were isolated. Human umbilical vein endothelial cells (HUVECs) were co-cultured with the pretreated EVs. After that, viability, colony formation ability, invasion, migration and tube formation ability of HUVECs were observed. Tumor xenograft in nude mice was performed to detect the effect of LINC00662, miR-195-5p or EV specific inhibitor GW4869 on tumor development.Results: LINC00662 and VEGFA were upregulated while miR-195-5p was downregulated in the cancer tissue of patients with ESCC. EVs derived from ESCC cells promoted viability, colony formation ability, invasion and tube formation ability of HUVECs. Downregulation of LINC00662 or upregulation of miR-195-5p reversed the promotion of EVs derived from ESCC cells on the viability, colony formation ability, invasion and tube formation ability of HUVECs in vitro and in vivo. VEGFA overexpression reversed EVs carrying restored miR-195-5p induced effects on HUVECs in vitro.Conclusion: In summary, elevated LINC00662 transferred by ESCC cells-derived EVs induces angiogenesis through downregulating miR-195-5p and upregulating VEGFA.
Lack of Effects of Renin-Angiotensin-Aldosterone System Activity and Beta-Adrenoceptor Pathway Polymorphisms on the Response to Bisoprolol in Hypertension
Authors: Zeng Weiwei , Chu Tanya T. W. , Ho Chung Shun , Lo Clara W. S. , Chan Alan S. L. , Kong Alice P. S. , Tomlinson Brian , Chan Sze Wa 
Published: April 2022

PurposeThis study examined the effects of plasma renin activity (PRA), angiotensin II (Ang II) and aldosterone (PAC) concentrations as well as common polymorphisms in the β1-Adrenoceptor gene (ADRB1) and the G-protein α-Subunit (Gαs) protein gene the G protein α-Subunit 1 gene (GNAS) on the blood pressure (BP) and heart rate (HR) response to bisoprolol in Chinese patients with hypertension.MethodsPatients with sitting clinic systolic BP (SBP) 140–169 mmHg and/or diastolic BP (DBP) 90–109 mmHg after placebo run-in were treated with open-label bisoprolol 2.5 mg daily for 6 weeks. Patients diagnosed as having primary aldosteronism or renal artery stenosis were excluded. PRA, Ang II and PAC concentrations were measured after the placebo run-in and after 6 weeks of treatment. The Ser49Gly and Arg389Gly polymorphisms in ADRB1 and the c.393C &gt; T polymorphism in GNAS were genotyped by the TaqMan® assay.ResultsIn 99 patients who completed the study, baseline PAC levels were significantly associated with baseline DBP and plasma potassium on univariate but not on multivariate linear regression analysis. PRA, Ang II, and PAC concentrations at baseline were not associated with changes in BP with bisoprolol treatment, but the values were all significantly reduced (PRA −0.141 ± 0.595 ng/mL/h, Ang II −2.390 ± 5.171 pmol/L and aldosterone −51.86 ± 119.1 pg/mL; all P &lt; 0.05) following 6 weeks of bisoprolol treatment. There were no significant differences in BP or HR responses in patients with baseline PRA above or below the PRA cut-point of 0.65 ng/mL/h or the median value of 0.9 ng/ml/hour. There were no significant associations of the ADRB1 and GNAS polymorphisms with the clinic and ambulatory BP and HR responses to bisoprolol.ConclusionBaseline PRA, PAC and Ang II concentrations showed no significant association with the BP response to bisoprolol treatment, but all these parameters were reduced after 6 weeks of treatment with bisoprolol. The two common polymorphisms in ADRB1 and the c.393C &gt; T polymorphism in GNAS had no significant association with the BP and HR response to bisoprolol in these patients.
Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
Authors: Galian-Gay Laura , Escalona Silva Roxana Andreina , Teixidó-Turà Gisela , Casas Guillem , Ferrer-Sistach Elena , Mitroi Cristina , Mingo Susana , Monivas Vanessa , Saura Daniel , Vidal Bàrbara , Trasca Livia , Moral Sergio , Calvo Francisco , Castiñeira Busto Maria , Sánchez Violeta , Gonzalez Ariana , Guzman Gabriela , Mora Marta Noris , Arnau Vives MiguelÁngel , Peteiro Jesús , Bouzas Alberto , Mas-Stachurska Aleksandra , González-Alujas Teresa , Gutiérrez Laura , Fernandez-Galera Rubén , Valente Filipa , Guala Andrea , Ruiz-Muñoz Aroa , Avilés Cesar Augusto Sao , Palomares José F. Rodríguez , Ferreira Ignacio , Evangelista Artur 
Published: April 2022

ObjectivesTo determine the risk of mortality and need for aortic valve replacement (AVR) in patients with low-flow low-gradient (LFLG) aortic stenosis (AS).MethodsA longitudinal multicentre study including consecutive patients with severe AS (aortic valve area [AVA] &lt; 1.0 cm2) and normal left ventricular ejection fraction (LVEF). Patients were classified as: high-gradient (HG, mean gradient ≥ 40 mmHg), normal-flow low-gradient (NFLG, mean gradient &lt; 40 mmHg, indexed systolic volume (SVi) &gt; 35 ml/m2) and LFLG (mean gradient &lt; 40 mmHg, SVi ≤ 35 ml/m2).ResultsOf 1,391 patients, 147 (10.5%) had LFLG, 752 (54.1%) HG, and 492 (35.4%) NFLG. Echocardiographic parameters of the LFLG group showed similar AVA to the HG group but with less severity in the dimensionless index, calcification, and hypertrophy. The HG group required AVR earlier than NFLG (p &lt; 0.001) and LFLG (p &lt; 0.001), with no differences between LFLG and NFLG groups (p = 0.358). Overall mortality was 27.7% (CI 95% 25.3–30.1) with no differences among groups (p = 0.319). The impact of AVR in terms of overall mortality reduction was observed the most in patients with HG (hazard ratio [HR]: 0.17; 95% CI: 0.12–0.23; p &lt; 0.001), followed by patients with LFLG (HR: 0.25; 95% CI: 0.13–0.49; p &lt; 0.001), and finally patients with NFLG (HR: 0.29; 95% CI: 0.20–0.44; p &lt; 0.001), with a risk reduction of 84, 75, and 71%, respectively.ConclusionsParadoxical LFLG AS affects 10.5% of severe AS, and has a lower need for AVR than the HG group and similar to the NFLG group, with no differences in mortality. AVR had a lower impact on LFLG AS compared with HG AS. Therefore, the findings of the present study showed LFLG AS to have an intermediate clinical risk profile between the HG and NFHG groups.
Screening of Lipid Metabolism-Related Gene Diagnostic Signature for Patients With Dilated Cardiomyopathy
Authors: Xu Man , Guo Ying-ying , Li Dan , Cen Xian-feng , Qiu Hong-liang , Ma Yu-lan , Huang Si-hui , Tang Qi-zhu 
Published: April 2022

BackgroundDilated cardiomyopathy (DCM) is characterized by enlarged ventricular dimensions and systolic dysfunction and poor prognosis. Myocardial lipid metabolism appears abnormal in DCM. However, the mechanism of lipid metabolism disorders in DCM remains unclear.MethodsA gene set variation analysis (GSVA) were performed to estimate pathway activity related to DCM progression. Three datasets and clinical data downloaded from the Gene Expression Omnibus (GEO), including dilated cardiomyopathy and donor hearts, were integrated to obtain gene expression profiles and identify differentially expressed genes related to lipid metabolism. GO enrichment analyses of differentially expressed lipid metabolism-related genes (DELs) were performed. The clinical information used in this study were obtained from GSE21610 dataset. Data from the EGAS00001003263 were used for external validation and our hospital samples were also tested the expression levels of these genes through RT-PCR. Subsequently, logistic regression model with the LASSO method for DCM prediction was established basing on the 7 DELs.ResultsGSVA analysis showed that the fatty acid metabolism was closely related to DCM progression. The integrated dataset identified 19 DELs, including 8 up-regulated and 11 down-regulated genes. A total of 7 DELs were identified by further external validation of the data from the EGAS00001003263 and verified by RT-PCR. By using the LASSO model, 6 genes, including CYP2J2, FGF1, ETNPPL, PLIN2, LPCAT3, and DGKG, were identified to construct a logistic regression model. The area under curve (AUC) values over 0.8 suggested the good performance of the model.ConclusionIntegrated bioinformatic analysis of gene expression in DCM and the effective logistic regression model construct in our study may contribute to the early diagnosis and prevention of DCM in people with high risk of the disease.
A Novel Strategy to Simplify the Procedures in Treating Complicated Coronary Bifurcation Lesions: From a Bench Test to Clinical Application
Authors: Li Dongdong , Ma Wenshuai , Liu Pengyun , Liu Hao , Bai Baobao , Zhang Mingming , Guo Wangang 
Published: April 2022

BackgroundAlthough provisional stenting strategy based on jailed balloon side branch (SB) protection could be useful for high-risk bifurcation lesion in certain clinical scenarios, its complexity still gives rise to procedure complications. We proposed a novel strategy, the jailed balloon proximal optimization technique (JB-POT), to simplify the procedures in treating complex coronary bifurcation lesions (CBLs). The present study was designed to verify the safety and efficacy of JB-POT under bench testing and clinical circumstances.MethodsAfter a stent was deployed in main vessel (MV) with a balloon jailed in SB, POT and post-dilation of the stent were performed without retrieving the jailed balloon. A re-POT was performed 2 mm away from SB branching point to minimize proximal stent malapposition. The JB-POT procedure was performed on 10 samples of a silicone bifurcation bench model, and optical coherence tomography (OCT) was utilized to evaluate stent deployment. From December 2018 to July 2021, a total of 28 consecutive patients with true CBLs treated with JB-POT were enrolled. Immediate procedure results were observed, and clinical follow-ups were performed.ResultsThe bench test showed that JB-POT did not induce significant stent malapposition, underexpansion or distortion, as indexed by the malapposition rate, minimum stent area (MSA), eccentricity index and symmetry index determined through OCT. Under clinical circumstances, JB-POT did not induce significant malapposition, underexpansion or distortion. Among the 30 lesions, there was no primary endpoint event defined as SB occlusion, need to rewire the SB with a polymer-covered guide wire, or failure to retrieve a jailed wire or balloon. One rewiring event and 0 double stenting events occurred as secondary endpoint events. One patient died of heart failure in the 8th month after discharge.ConclusionsThe JB-POT protocol, which tremendously simplifies the current standard provisional stenting procedure in complicated bifurcation lesions, shows acceptability in safety and efficacy. Hence, it might become an applicable strategy for treating high-risk bifurcation lesions, especially those with multiple risked SBs.
Mantle and Crustal Xenoliths in a Tephriphonolite From La Palma (Canary Islands): Implications for Phonolite Formation at Oceanic Island Volcanoes
Authors: Klügel Andreas , Albers Elmar , Hansteen Thor H. 
Published: April 2022

The occurrence of mantle-derived peridotite xenoliths in phonolitic melts is a rare phenomenon, and is commonly ascribed to a mantle origin of the phonolite. The alternative possibility, that xenoliths are transported into evolving phonolite melts by mafic magmas, has received little attention. A unique tephriphonolite lava with phonolitic groundmass composition, from the active Cumbre Vieja volcano of La Palma (Canary Islands), allows to test these models. The lava contains abundant inclusions that represent the island’s major xenolith types: kaersutite-dominated cumulates, gabbros from the lower oceanic crust, and peridotites from the mantle. Our petrological investigations indicate that the tephriphonolite magma contained 3–4 wt% H2O and was stored in the lower crust at around 250–350 MPa and 900–950°C, at oxidized conditions (∆NNO of 2–3). The peridotite xenoliths are mantled by complex polyphase selvages, with adjacent up to 1.6 mm wide zonations where olivine compositions change from Fo78-86at the selvage contact to Fo89-91inside the xenoliths. We carried out diffusion modelling for Fe-Mg exchange and found that the peridotites had contact with intermediate to evolved alkaline melts over decades to centuries. This timescale is comparable to that inferred for basanite-hosted peridotite xenoliths from Cumbre Vieja. The following model is proposed: differentiation of evolved melts occurs in a magma accumulation zone in the lowermost oceanic crust beneath La Palma. The evolving melts receive periodic recharge by mantle-derived mafic magmas at intervals on the order of decades to a few centuries, comparable to historic eruption recurrences (80 years on average). Some of these recharge pulses carry mantle peridotite fragments that become deposited in the accumulation zone. Thus, these xenoliths do not reflect formation of the evolved melts in the mantle. Final ascent of the tephriphonolite was triggered by magma recharge some weeks before its eruption, resulting in entrainment and thorough mingling of a mixed xenolith population (cumulates, oceanic crust gabbros, peridotites). We infer that formation of phonolites in the lower crust beneath oceanic island volcanoes, and subsequent eruption, requires a balance between rates and volumes of magma recharge pulses and of eruptive events.
Sex Differences in Obesity and Cognitive Function in Chinese Elderly Patients With Chronic Schizophrenia
Authors: Li Wei , Lin Sun , Yue Ling , Fang Yuan , Xiao Shifu 
Published: April 2022

BackgroundIt is well known that schizophrenia is associated with sex differences. However, no study has explored the sex differences in obesity and cognitive function in elderly Chinese patients with schizophrenia.ObjectiveThis study aimed to compare sex differences in obesity and cognitive function in elderly Chinese individuals with schizophrenia.MethodsA total of 304 elderly patients with schizophrenia and 130 sex- and age-matched healthy controls from the community were recruited. Demographic, clinical, and lipid parameters were collected for all subjects. The Montreal Cognitive Assessment (MoCA) was used to assess the global cognitive functions of the participants, while the Positive and Negative Syndrome Scale (PANSS) was used to assess psychopathological symptoms in patients with schizophrenia.ResultsOf the patients with schizophrenia, the prevalence of obesity in men and women was 11.7% (19/163) and 21.3% (30/141), respectively. The score (14.51 ± 6.504) of MOCA in elderly male patients with schizophrenia was significantly higher than that (11.40 ± 6.822) in female patients. There was a positive correlation between the MOCA scores and body mass index (BMI) (r=0.206, p=0.018) in male elderly patients with schizophrenia. Conversely, the MOCA scores of female elderly patients with schizophrenia did not correlate with BMI (p&gt;0.05). However, we found no sex differences in obesity and cognition among control older adults.ConclusionsOur findings suggest that there are significant sex differences in obesity and cognitive function in elderly Chinese patients with schizophrenia.