bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between conservative and prophylactically concurrent meniscoplasty on the asymptomatic knee in children with unilaterally symptomatic bilateral discoid lateral meniscus operated on the symptomatic side: a retrospective study and literature review
Authors: You Mingke , Li Pengcheng , Zhang Kaibo , Zhou Kai , Chen Gang , Li Jian 
Published: October 2022

Abstract
Background
The literature compared conservative treatment and concurrent meniscoplasty for children with asymptomatic discoid lateral meniscus. This study aimed to compare the clinical outcomes between concurrent meniscoplasty and conservative management on the asymptomatic side in children with unilaterally symptomatic bilateral discoid lateral meniscus (DLM) operated on the symptomatic side.
Methods
In the literature review, three databases were searched up to September 2021. In the retrospective study, patients under 14 with unilaterally symptomatic bilateral DLM who underwent arthroscopic meniscoplasty were eligible. Patients were divided into two groups: children in group 1 underwent meniscoplasty on the symptomatic side, with the asymptomatic side conservatively treated. Children in group 2 underwent meniscoplasty on both the symptomatic and asymptomatic sides concurrently. Functional outcomes were evaluated using the Lysholm score and Ikeuchi score. Survival analysis of the occurrence of symptoms was applied by the Kaplan‒Meier model.
Results
In the literature review, 3 studies suggested for no treatment, 3 for observation only, 7 for non-surgical treatment, 1 considered it debating, and 1 recommended for prophylactic surgery. In the retrospective study, a total of 44 patients (34 female and 10 male) were eligible. For the average Lysholm scores, groups 1 and 2 of the previously asymptomatic side were 90.86 ± 8.25 and 92.67 ± 9.10, respectively. For the symptomatic side, the Lysholm scores were 91.38 ± 8.90 and 95.33 ± 7.18, respectively. The mean survival time was 9 years in group 1 and 5 years in group 2. The Kaplan‒Meier survival analysis of the occurrence of symptoms showed no statistically significant difference between the two groups (p = 0.121), and the terminal survival rates in the two groups were 86.2% and 80.0%, respectively.
Conclusions
No significant difference was reported on the asymptomatic side of conservative and surgical group in functional scores, while conservative group showed lower occurrence of symptoms and longer survival time.
Trial registration
The trial had been registered on the Chinese Clinical Trial Registry, with the number ChiCTR2000034577.
Bioberturk: Exploring Turkish Biomedical Language Model Development Strategies in Low Resource Setting
Authors: Turkmen Hazal , Dikenelli Oguz , Eraslan Cenk , Callı Mehmet Cem 
Published: October 2022

Abstract
Pretrained language models elevated with in-domain corpora show impressive results in biomedicine and clinical NLP tasks in English. However, there is minimal work in low resource languages. Although some pioneering works show promising results, many scenarios still need to be explored to engineer effective pretrained language models in biomedicine for low resource settings. This work introduces the BioBERTurk family, four pretrained models in Turkish for biomedicine. To evaluate models, we also introduce a labeled dataset to classify radiology reports of head CT exams. Two different parts of the reports, impressions, and findings, are evaluated separately to observe the performance of models on longer and less informative text. We compare models with the Turkish BERT-BERTurk pretained with general domain text, multilingual BERT, and an LSTM+attention-based baseline model. The first model initialized from BERTurk and then further pretrained with biomedical corpus performs statistically better than BERTurk, multilingual BERT, and baseline for both datasets. The second model continues to pretrain BERTurk model by using only radiology Ph.D. theses to test the effect of the task-related text. This model slightly outperforms all models on the impressions dataset and showed that using only radiology-related data for continual pretraining could be effective. The third model continues to pretrain by adding radiology theses to biomedical corpus but does not show a statistically meaningful difference. The final model combines radiology and biomedicine corpora with the corpus of BERTurk and pretrained a BERT model from scratch. This model is the worst performed model of the BioBERT family, even worse than BERTurk and multilingual BERT.
Simultaneous optimization of factors affecting native starch pretreatment and enzymatic hydrolysis using magnetic covalent immobilized α-amylase
Authors: Khazaei Shadi , Hejazi Parisa 
Published: October 2022

Abstract
In this study, for the first time the effects of different factors on hydrolysis of low concentration of corn starch were investigated in two steps. In the first step, thermal hydrolysis with pH variation and sonication treatment and finally enzymatic hydrolysis of starch were investigated by one factor at a time method. The best conditions of maximum reducing sugar production and maximum releasing of amylose were starch with pH = 4.5, sonication time 30 min and 24 hours solution storage in 4°C with enzymatic hydrolysis by 335 ppm immobilized enzyme for 15 min. In the second step, the effects of three variables on starch hydrolysis to determine the optimal conditions were investigated by 23 factorial design with multiple responses desirability method. Starch concentration 0.5% (w/v), initial starch pH of 4.5 and enzymatic hydrolysis temperature 50°C were determined as optimum conditions for achieving maximum changes in reducing sugar concentration 92.48 (mg/g starch) and ratio of final and initial soluble amylose content of hydrolysate solution 0.62 (by more than 75% separation of immobilized enzyme on MNPs after the process by external magnetic field. Also, experiment showed the possibility of immobilized enzyme reusing, which can retain 40% of its ability to produce reducing sugar and retain magnetic features of nanoparticles after 6 cycles.
Cost-effectiveness of sintilimab plus bevacizumab biosimilar versus sorafenib for unresectable hepatocellular carcinoma
Authors: Jia Wang , Xin Wen , Jing Su , Qin Kan 
Published: October 2022

Abstract
Aims
Sintilimab plus bevacizumab biosimilar(IBI305) as a first-line therapy for patients with unresectable hepatocellular carcinoma has been shown to improve overall and progression-free survival compared with standard sorafenib treatment. The aim of current economic evaluation is to investigate the cost-effectiveness of sintilimab in combination with IBI305 as a first-line therapy for unresectable hepatocellular carcinoma.
Methods
A partitioned survival model consisting of 3 discrete health states to was constructed to evaluate the economic outcome of sintilimab plus bevacizumab biosimilar. Costs, life-years, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICER) of sintilimab plus bevacizumab biosimilar vs sorafenib was examined. One-way deterministic sensitivity, probabilistic sensitivity and subgroup analyses were used to examine model uncertainty.
Results
The base-case results found that sintilimab plus IBI305 treatment for unresectable HCC could bring an extra 0.49 QALYs and 1.269 overall life-years, with an incremental cost of $16487. The ICER for sintilimab plus IBI305 vs sorafenib was $28022.58/QALY. The probability of being cost-effective for sintilimab in combination with IBI305 increased from 28–62% as the willingness-to-pay (WTP) threshold value increased from $26000/ QALY to $29000/QALY.
Conclusion
The findings of this study suggested that that sintilimab plus IBI305 is a cost-effective strategy from the Chinese perspectives.
Unipolar Euler-Poisson equations with time-dependent damping: blow-up and global existence
Authors: Xu Jianing , Chen Shaohua , Mei Ming , Qin Yuming 
Published: October 2022

Abstract
This paper is concerned with the Cauchy problem for one-dimensional unipolar Euler-Poisson equations with time-dependent damping, where the time-asymptotically degenerate damping in the form of − μ/(1+t)λ ρu for λ > 0 with μ > 0 plays a crucial role for the structure of solutions. The main issue of the paper is to investigate the critical case with λ = 1. We first prove that, for all cases with λ > 0 and μ > 0 (including the critical case of λ = 1), once the initial data is steep at a point, then the solutions are locally bounded but their derivatives will blow up in finite time, by means of the method of Riemann invariants and the technical convex analysis. Secondly, for the critical case of λ = 1 with μ > 7/3, we prove that there exists a unique global solution, once the initial perturbation around the constant steady-state is sufficiently small. In particular, we derive the algebraic convergence rates of the solution to the constant steady-state, which are piecewise, related to the parameter μ for 7/3 < μ ≤ 3, 3 < μ ≤ 4 and μ > 4. The adopted method of proof in this critical case is the technical time-weighted energy method and the time-weight depends on the parameter μ. Finally, we carry out some numerical simulations in two cases for blow-up and global existence, respectively, which numerically confirm our theoretical results.
Assessment of the honey purity by using imaging polarimetry technique
Authors: Tepeli Anthony , Sanzu Loema , Charles Philipo 
Published: October 2022

Abstract
The imaging polarimetry technique has wide range of application in modern science technologies however the adulteration of honey purity is a global challenge in honey industries so the research was carried out purposefully to assess the quality of honey by using different polarization parameters obtained from imaging polarimetry techniques which was applied on the honey samples mixed with different adulterants (glucose, fructose, sucrose). This was done specifically to make variation in the polarization parameters of the two honey sample. Method; The experiment was achieved by using optical device that were attached in optical bench were the laser light was passed through the beam expander and illuminated toward the sample. The image was then taken with angle variation of 22.5ᵒ and labeled as I0, taken at angle 45ᵒ labeled I1, image taken from angle 67.5ᵒ, 90ᵒ, 112.5ᵒ, 135ᵒ, 157.5ᵒ and 180ᵒ were labeled as I2, I3, I4, I5, I6 and I7 respectively and the eight images of each sample were captured. Using the captured images of the sample the polarization parameters (DOP, DOCP, DLP) of all samples were obtained and tabulated in the table with their mean and standard deviation. Results; The mean and standard deviation obtained from the (DOP, DOCP, DLP) histogram curve showed the good variation of pure sample and their relative adulterants and it was observed that the variation in impure sample was irregular due to adulterants and impurities already present in the sample. Conclusion; the degree of circular polarization was found to be more successful in quantifying the honey purity as the matter of fact that the intensity images of DOCP was much way greater than the others and the histogram of DOCP covered the large part of the histogram amount.
Groundwater management study through index construction and its reliability evaluation with discriminant analysis
Authors: Barranquero Rosario Soledad , Nicora Bethania , Etcheverría Silvina Graciela , Dipardo Bruno , Landa Roberto , Gonzalez Juliana , Tabera Anahí 
Published: October 2022

Abstract
Manuscript’s motivation was to contribute to the water resources integral management approach that implies joint consideration of variables related to the water quality, its use, and their interactions. To address this complexity two statistical tools, index number model and discriminant analysis, were combined. The objective was to construct several index for the water management analysis of rural schools in the Tandil district (Buenos Aires, Argentina) and evaluate its reliability through multivariate analysis. Different water quality index based on physicochemical and microbiological analysis in water samples was constructed. A handling water index from surveys made in rural schools was constructed. 69% of the schools have good result of the water quality index, while only 31% had a handling index high result. It was shown that in the rural territory the water potability conditions are compromised fundamentally due to the lack of stakeholder’s empowerment and the absence of an institutional policy. Methodology used resulted adequately and can be applied with low cost of obtaining information to other environmental problems that require the integration of qualitative and quantitative variables. It therefore represents an advance for applied statistics since it allows dealing with the complexity of the variables combination without losing mathematical reliability.
The impact of corporate governance on the performance of banking sector in GCC: does the political connection matter during crisis?
Authors: CHAARANI Hani EL 
Published: October 2022

Abstract
This research paper aims to explore whether the corporate governance structure and political connection played an efficient role in preventing the negative impact of crisis, namely the Covid-19 crisis in GCC banks. Based on a data of 326 banks observations from 6 countries (Bahrain, Kuwait, Oman, Qatar, United Arab Emirates and Saudi Arabia), the results of t-test, fixed-effect, 2SLS and GMM models provide new insights regarding the political connection and corporate governance design in GCC banking sector. The results of this study show that banks do not change their corporate governance structure during crisis. Furthermore, the results indicate that both independent members on board of directors and political ownership concentration mitigate the negative impact of crisis and enhance the financial performance of banks in GCC. Finally, the results show that large banks that sustain their operational activities have large capacity to resist during crisis. The findings will be useful for bankers, regulators, central banks and governments within GCC. The results will guide them to review the governance structure to mitigate the negative impact of any future crisis.
Radiosensitizing effect of MEK-inhibition in glioblastoma in vitro and in vivo
Authors: Houweling M. , Abdul U. K. , Brahm C. , Lagerweij T. , Heukelom S. , Koken P. W. , Honeywell R. , Wedekind L. E. , Peters G. J. , Verheul H. , Sminia P , Noske D. , Wurdinger T. , Westerman BART 
Published: October 2022

Abstract
Glioblastoma (GBM) is an incurable cancer type. New therapeutic options are investigated, including targeting the mitogen-activated protein kinase (MAPK) pathway using MEK-inhibitors as radiosensitizers. In this study, we investigated whether MEK-inhibition via PD0325901 leads to radiosensitization in experimental in vitro and in vivo models of GBM. In vitro, GBM8 multicellular spheroids were irradiated with 3 fractions of 2 Gy, during 5 consecutive days of incubation with either PD0325901 or MEK-162. Regrowth and viability of spheroids monitored until day 18, showed that both MEK-inhibitors had an in vitro radiosensitizing effect. In vivo, PD0325901 concentrations were relatively constant throughout multiple brain areas. We combined PD0325901 with radiotherapy in the GBM8 orthotopic mouse model. Tumor growth was measured weekly by bioluminescence imaging and overall survival and toxicity were assessed, showing temporal PD0325901-related adverse events such as dermatitis in 4 out of 14 mice (29%). Mice that were treated with radiation alone or combined with PD0325901 had significantly better survival compared to vehicle (both P<0.005), however, no significant interaction between PD0325901 MEK-inhibition and irradiation was observed. The difference between the radiotherapy-enhancing effect of PD0325901 in vitro and in vivo urges further pharmacodynamic/pharmacokinetic investigation of PD0325901 and possibly other candidate MEK inhibitors.
“We want our therapist to talk with us about sexuality and gender diversity”: Qualitative perspectives of adolescents and professionals in youth mental health care.
Authors: Bungener Sara Lianne , Verveen Anouk , Steensma Thomas Dirk , de Vries Annelou , Popma Arne , de Kruif Anja 
Published: October 2022

Abstract
Introduction: For youth with psychiatric conditions, sexual and gender identity development can be challenging. Mental health care professionals (MHPs) often avoid communication about sexuality, sexual side effects, and gender diversity with youth. The aim of this study is to gain insight into the perspectives of youth in mental health care and professionals about sexuality and gender diversity communication.
Methods: In-depth interviews with 21 adolescent patients (aged 15–22 years) and focus groups were conducted with 20 MHPs (aged 26–55 years) at a mental health care institution in Amsterdam. During analysis, the experiences, needs, and underlying inhibiting and facilitating factors of both groups were derived and analyzed.
Results: Both youth patients and MHPs stated that sexuality and gender identity should be a part of mental health care. Youth described the impact and interplay between mental health, sexuality (e.g., sexual experiences, romantic relations, sexual orientation), and gender identity. Both groups want sexual side effects of psychotropic medication to be addressed when prescribing medication. Cultural and faith-based factors should be considered, especially for LGBT+ youth.
Conclusion: Youth patients and MHPs feel that sexuality and gender identity should be a standard part of youth mental health care. Confidential conversation with an MHP can provide a designated place to talk about these sensitive subjects. Mental health care institutions should implement sexuality and gender diversity communication in clinical practice.
Hyperparameter Optimization of Generative Adversarial Network Models for High-Energy Physics Simulations
Authors: Dumont Vincent , Ju Xiangyang , Mueller Juliane 
Published: October 2022

Abstract
The Generative Adversarial Network (GAN) is a powerful and flexible tool that can generate high-fidelity synthesized data by learning. It has seen many applications in simulating events in High Energy Physics (HEP), including simulating detector responses and physics events. However, training GANs is notoriously hard and optimizing their hyperparameters even more so. It normally requires many trial-and-error training attempts to force a stable training and reach a reasonable fidelity. Significant tuning work has to be done to achieve the accuracy required by physics analyses. This work uses the physics-agnostic and high-performance-computer-friendly hyperparameter optimization tool HYPPO to optimize and examine the sensitivities of the hyperparameters of a GAN for two independent HEP datasets. This work provides the first insights into efficiently tuning GANs for Large Hadron Collider data. We show that given proper hyperparameter tuning, we can find GANs that provide high-quality approximations of the desired quantities. We also provide guidelines for how to go about GAN architecture tuning using the analysis tools in HYPPO.
Study of Potassium inducing Iron toxicity tolerance in rice: morphology, biochemical estimation, interaction between NAS3 and FER protein
Authors: Singh Banhishikha , Banerjee Soma 
Published: October 2022

Abstract
Excessive iron absorption by rice plants often suffers from iron (Fe) toxicity and mineral nutrient deficiency which influences the rice yield. High amount of Fe, generates reactive oxygen species which is the major damage causing agent to the cellular components and induces membrane lipid peroxidation. Antioxidants like Catalase (CAT) and Ascorbate peroxidase (APX) give tolerance to the rice plants by reducing toxic free-radicals induced by Fe2+. Application of potassium (K) can improve plant the oxidation status and this study is based on the biological responses, protein and their respective gene expressions at the same time, to enlarge the ameliorative effect of K+. Seven days old Rice seedlings were exposed to 750 ppm of FeSO4.7H2O and treated with 100–200 ppm of KCl for futher 14 days. Estimation of shoot and root length, Chlorophyll pigments, reducing sugar content, starch content, lipid peroxidation, CAT and APX along with FTIR were carried out to analysis the ameliorative effect of potassium against Fe toxicity in the treated rice seedlings. The interaction between NAS 3 with FER was also found in the STRING database. The gene expression and protein bands were also showed the interaction of NAS 3 with FER was also induced with the exogenous application of potassium against Fe toxicity in the seedlings of the locally cultivable rice varieties of West Bengal.
Effects of different drugs and hormone treatment on Toxoplasma gondii glutathione S-Transferase 2
Authors: Li Shuang , Liu Jing , Ying Zhu , Xue Yangfei , Sun Zhepeng , Liu Qun 
Published: October 2022

Abstract
Background：Glutathione S-transferase (GST) in eukaryotic organisms has multiple functions such as detoxifying endogenous/exogenous harmful substances to protect cells from oxidative damage, participating in sterol synthesis and metabolism, and regulating signaling pathways. Our previous work identified an important GST protein in Toxoplasma that contributes to vesicle trafficking called TgGST2, the deletion of which significantly reduces the virulence of the parasite. Meanwhile, we also considered that TgGST2 may also play a role in other pathways of parasite life activities.
Methods:The tertiary structures of TgGST2 as well as estradiol (E2) and progesterone (P4) were predicted by trRosetta and Autodock Vina software, the binding sites were analyzed by PyMol's GetBox Plugin, and the binding capacity was evaluated using Discovery Studio plots software. We examined the influence of E2 and P4 on TgGST2 via glutathione S-transferase enzyme activity and indirect immunofluorescence assay (IFA) and through the localization observation of TgGST2 to evaluate its response-ability in different drugs.
Results: TgGST2 could bind to exogenous E2 and P4 and that enzymatic activity were inhibited by the hormones in a concentration-dependent manner. Upon P4 treatment, the localization of TgGST2 changed to hollow circles, leading to abnormal localization of the molecular transporter Sortilin (VPS10) and microneme proteins (M2AP and MIC2), which ultimately affect the parasite life activities, but E2 had no significant effect. Moreover, diverse types of drugs had divergent effects on TgGST2, among which treatment with antifungal agents (voriconazole and clarithromycin), anticarcinogens (KU-60019, WYE-132 and SH5-07) and coccidiostats (dinitolmide and diclazuril) made the localization of TgGST2 appear in different forms, including dots, circles and rod-shaped.
Conclusions:Our study shows that TgGST2 plays a role in sterol treatment and can be affected by P4, which leads to deficient parasite motility. TgGST2 exerts divergent effects in response to the different properties of the drugs themselves. Its responsiveness to diverse drugs implies a viable target for the development of drugs directed against Toxoplasma and related pathogenic parasites.