bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain control with punch grafting in ulcers with underlying arteriolosclerosis
Authors: Quintana-Castanedo Lucía , Conde-Montero Elena , Recarte-Marín Lorena , Peral-Vázquez Alicia , Pérez-Jerónimo Laura , de la Cueva-Dobao Pablo 
Published: April 2022

Objective:Martorell hypertensive ischaemic ulcers are often misdiagnosed and can be a clinical and therapeutic challenge. Controversy exists regarding both their underlying triggers and the type of treatment that should be carried out. This study was designed to compare the effectiveness of punch grafting and conventional therapy in pain reduction.Method:A single-centre retrospective study was performed, including 40 patients with a clinical diagnosis of a Martorell ulcer or post-traumatic ulcer secondary to arteriolopathy in the elderly, who were treated with punch grafting (n= 24) or conventional medical treatment (n=16).Results:There was a statistically and clinically significant reduction in pain after punch grafting. The minimal overall reduction was of three points in visual analogue pain scores. Of the patients who received punch grafting, 80% reported a VAS pain score of 0 at the third follow-up, in contrast with the 44% (n=4) patients who were treated without punch grafting. The mean time to epithelialisation was 82.1 days in patients who received conventional treatment and 43.5 days in those who received punch grafts.Conclusion:Punch grafting is a simple, validated and cost-effective technique that can be performed on an outpatient basis, promotes wound healing and reduces pain. It may control pain and stimulate epithelialisation even if the wound does not present with optimum wound bed characteristics for graft taking. Pain reduction and faster epithelialisation are associated with improvements in patients' quality of life.
Transfer learning approach toward joint monitoring of bit rate and modulation format
Authors: Jha Dhirendra Kumar , Mishra Jitendra K. 
Published: April 2022

Convolutional neural network based transfer learning (TL) is proposed to achieve joint optical performance monitoring with bit rate and modulation format identification in optical communication systems. TL is used to improve the execution of various tasks by extracting features without knowing other optical link parameters. Eye diagrams of four different modulation formats are generated at optical signal-to-noise ratios (OSNRs) varying from 15 to 30 dB for two distinct bit rates, which are then identified simultaneously with a trained deep neural network. In addition, comparisons of different TL approaches are presented. The database is divided into distinct categories with varying parameter ranges in offline mode, and prediction models are assigned to each class. The results suggest that the proposed system may greatly increase identification performance over existing strategies by utilizing TL techniques. The impacts of training, testing, and validation data size, as well as model structure based on TL, are also thoroughly investigated. The results reveal that the VGG16 achieves the highest accuracies compared to other deep learning algorithms even at low OSNR values of 20 dB. The proposed structure can intelligently evaluate the signals of future heterogeneous optical communications, and the results can be used to enhance optical network management.
Outcome of acute bacterial meningitis among children in Kandahar, Afghanistan: A prospective observational cohort study
Authors: Rahimi Bilal Ahmad , Ishaq Niamatullah , Mudaser Ghulam Mohayuddin , Taylor Walter R. 
Published: April 2022

Background
Acute bacterial meningitis (ABM) is an important cause of morbidity and mortality in children but there are no published data on the treatment outcomes of ABM in Afghanistan.

Methods
We conducted a prospective observational cohort study over one year, February 2020 to January 2021 in a tertiary care hospital in Kandahar, Afghanistan. AMB was diagnosed clinically and on lumbar puncture findings. Binary logistic regression assessed factors for death.

Results
A total of 393 ABM children of mean age 4.8 years were recruited. Most were males [231 (58.8%)], living in rural areas [267 (67.9%)] and in households of >10 inhabitants [294 (74.8%)]. Only 96 (24.4%) had received against both Haemophilus influenzae type b (Hib) or pneumococcal (PCV) vaccines. Children were treated with combination of ceftriaxone and ampicillin and 169/321 (52.6%) received dexamethasone. Of the 321 children with a known outcome, 69 (21.5%) died. Death was significantly associated with: not receiving dexamethasone [adjusted odds ratio (AOR) 4.9 (95% CI 2.6–9.5, p <0.001)], coma on admission [AOR 4.6 (I 2.3–9.5, p <0.001)], no PCV [AOR 2.8 (1.2–6.6, p = 0.019)] or Hib vaccine [AOR 2.8 (1.2–6.6, p = 0.019)], and being male [AOR 2.7 (1.4–5.5, p = 0.005).

Conclusions
ABM causes significant morbidity and mortality in Afghan children that may be improved by greater use of PCV and Hib vaccines. Adjunct dexamethasone should be evaluated formally in our setting.
Cardiovascular vulnerability predicts hospitalisation in primary care clinically suspected and confirmed COVID-19 patients: A model development and validation study
Authors: van Royen Florien S. , Joosten Linda P. T. , van Smeden Maarten , Slottje Pauline , Rutten Frans H. , Geersing Geert-Jan , van Doorn Sander 
Published: April 2022

Objectives
Cardiovascular conditions were shown to be predictive of clinical deterioration in hospitalised patients with coronavirus disease 2019 (COVID-19). Whether this also holds for outpatients managed in primary care is yet unknown. The aim of this study was to determine the incremental value of cardiovascular vulnerability in predicting the risk of hospital referral in primary care COVID-19 outpatients.

Design
Analysis of anonymised routine care data extracted from electronic medical records from three large Dutch primary care registries.

Setting
Primary care.

Participants
Consecutive adult patients seen in primary care for COVID-19 symptoms in the ‘first wave’ of COVID-19 infections (March 1 2020 to June 1 2020) and in the ‘second wave’ (June 1 2020 to April 15 2021) in the Netherlands.

Outcome measures
A multivariable logistic regression model was fitted to predict hospital referral within 90 days after first COVID-19 consultation in primary care. Data from the ‘first wave’ was used for derivation (n = 5,475 patients). Age, sex, the interaction between age and sex, and the number of cardiovascular conditions and/or diabetes (0, 1, or ≥2) were pre-specified as candidate predictors. This full model was (i) compared to a simple model including only age and sex and its interaction, and (ii) externally validated in COVID-19 patients during the ‘second wave’ (n = 16,693).

Results
The full model performed better than the simple model (likelihood ratio test p<0.001). Older male patients with multiple cardiovascular conditions and/or diabetes had the highest predicted risk of hospital referral, reaching risks above 15–20%, whereas on average this risk was 5.1%. The temporally validated c-statistic was 0.747 (95%CI 0.729–0.764) and the model showed good calibration upon validation.

Conclusions
For patients with COVID-19 symptoms managed in primary care, the risk of hospital referral was on average 5.1%. Older, male and cardiovascular vulnerable COVID-19 patients are more at risk for hospital referral.
Pharmacological modulation of prostaglandin E2 (PGE2) EP receptors improves cardiomyocyte function under hyperglycemic conditions
Authors: Bosma Karin J. , Ghosh Monica , Andrei Spencer R. , Zhong Lin , Dunn Jennifer C. , Ricciardi Valerie F. , Burkett Juliann B. , Hatzopoulos Antonis K. , Damron Derek S. , Gannon Maureen 
Published: April 2022

AbstractType 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E2 (PGE2), are elevated in the setting of obesity and T2D and are associated with decreased cardiac function. The EP3 and EP4 PGE2 receptors have opposing actions in several tissues, including the heart: overexpression of EP3 in cardiomyocytes impairs function, while EP4 overexpression improves function. Here we performed complementary studies in vitro with isolated cardiomyocytes and in vivo using db/db mice, a model of T2D, to analyze the effects of EP3 inhibition or EP4 activation on cardiac function. Using echocardiography, we found that 2 weeks of systemic treatment of db/db mice with 20 mg/kg of EP3 antagonist, beginning at 6 weeks of age, improves ejection fraction and fractional shortening (with no effect on heart rate). We further show that either EP3 blockade or EP4 activation enhances contractility and calcium cycling in isolated mouse cardiomyocytes cultured in both normal and high glucose. Thus, peak [Ca2+]I transient amplitude was increased, while time to peak [Ca2+]I and [Ca2+]I decay were decreased. These data suggest that modulation of EP3 and EP4 activity has beneficial effects on cardiomyocyte contractility and overall heart function.
Experimental and Theoretical Approach to the Extrusion of Rubber Compounds with a Two-Stage Screw**
Authors: Vergnes B. , Bennani N. , Guichard C. 
Published: April 2022

AbstractThe extrusion of EPDM compounds with a two-stage vented screw has been studied. Experimentally, the pressures and temperatures were measured at the end of each stage, for different processing conditions (screw speed, die geometry etc.). Screw pulling experiments have allowed to observe the partially filling of the different screw sections. Assuming a power-law pseudoplastic behaviour for the rubber compound, the flow in each stage of the screw has been computed. The evolutions of the pressure and the temperature all along the screw, as well as the filling length of the second stage are then obtained. The theoretical results are in good agreement with the experimental measurements.
Simulation of Balancing Multi-Cavity Molds
Authors: Ghoneim H. 
Published: April 2022

Abstract
A finite element program is developed for simulating the non-isothermal flow of non-Newtonian liquids in a multi-cavity mold with convergent runners and gates of any arbitrary cross-sectional shape. The program is used to investigate the problem of balancing multi-cavity molds. Results of simulating an actual mold filling show that balancing can be achieved by using a straight runner together with convergent gates having successively increasing angles of convergence. In addition, a strategy for approximating those angles of convergence is suggested.
Late Roman emperorship in Constantinople: embodiment and ‘unbodiment’ of Christian virtues
Authors: Destephen Sylvain 
Published: April 2022

Abstract
The question of the documentary value of the last statues of Late Antiquity has been much debated in many recent publications. This article contributes to this debate and addresses emperors’ statuary and its relation to the development of a Christian theology of the Late Roman emperorship. Traditionally, statues demonstrated the military, legal and economic power of Roman emperors, who were depicted as generals, judges or benefactors. Surprisingly, the Christianisation of imperial power seems to have had a limited influence upon the official iconography of emperors. The religious dimension rarely appeared on statues even though they became rarer in Late Antiquity. Whilst literary sources, especially Christian sources, increasingly mentioned emperors’ personal piety and demonstrative humility, particularly in the monumental context of Constantinople, imperial statues remained faithful to the traditional iconography of power that obliterated physical weakness and embodied autocratic power.
A list of village payments and the bouleutic career of Theodoros
Authors: Kotyl Marcin 
Published: April 2022

Abstract
The article discusses the bouleutic career of certain Theodoros, son of Komasios flourished in fourth-century Hermopolis. Based on an edition of a new papyrus fragment (P.Giss. inv. 307), it argues that Theodoros - before he was the riparius in 362 CE - served as the praepositus pagi. Also, a revision of CPR VIII 36,7 reveals that at a certain point in his career Theodoros was called the prototypos poleos, which is a forerunner of the later proteuon or the honorary titulature for members of the city council.
“A statue of bronze, by which times of old used to honor men of rare example”: Materials of honorific statues in Late Antiquity
Authors: Öğüş Esen 
Published: April 2022

Abstract
It is the purpose of this article to present the archaeological, epigraphic and literary evidence on the materials of honorific statues in Late Antiquity with a fresh outlook to delve into their cultural meaning and potential for manipulation and power display. The article questions how material choice and employment fits the conventions of state tradition and social customs, whether certain materials were deemed more prestigious and appropriate for the statues of the imperial family versus other honorands, and whether this prestige depended on the cost of the material or other visual/cultural factors. The results of the inquiry show that the choice of materials depended on a mix of factors and diverse local practices, and of all the available materials, bronze remained as the most widely-manipulated one.
Justinianus Eponymus: Überlegungen zur letzten Glanzzeit kaiserlicher Namensverleihungen an Städte
Authors: Ritter Max 
Published: April 2022

Abstract
The emperor Justinian’s (527-565) penchant for naming institutional bodies after himself is a well-known feature of his reign - not only to modern scholarship but already for his contemporaries. The present study takes a closer look at the cities which were conferred the name of Justinian and Theodora since it may shed light on the emperor’s vision for the empire and his relations to the cities. The study sets off with an investigation of the various contexts, incentives and initiators for the grant of Justinian’s appellation to the cities. In brief, the confer of imperial epithets concerned the relation between the emperor and his subjects, who petitioned with him for this honour and received his name as a token of benevolence. The emperor’s favour conveyed power, and those below him strove to get his attention. In passing, the study also considers the longevity of the imperial eponyms. They did not usually stick in the subsequent centuries, partly because there were far too many cities named after the couple than was handy for the central administration, but also because the eponyms lost their function in the course of time.
Islamicate alchemy in Greek letters on the first page of Marcianus graecus 299
Authors: Roberts Alexandre 
Published: April 2022

Abstract
The famous middle Byzantine alchemical manuscript Marcianus graecus 299 contains annotations from the late Byzantine period, most prominently in its opening quire. This article examines a text on the very first page of the manuscript, a text written in a late Byzantine Greek script, but in a language other than Greek. A number of words in this undeciphered text can be correlated with Arabic technical vocabulary that would also have been used in other Islamicate languages such as Persian and Ottoman Turkish. Certain features such as accentuation on the final syllables of words make Turkish or Persian the most likely candidates.
The silk industry around Naupaktos and its implications
Authors: Wu Gang 
Published: April 2022

Abstract
The silk production around Naupaktos is better documented than other examples of the silk industry in Byzantine Central Greece, especially in terms of its organisation, industrial layout and technical parameters. However, in comparison with its much better-known Theban counterpart, the Naupactian silk industry remains underexplored in current scholarship. This article focuses on synthesising the information about the industry provided by the surviving writings of John Apokaukos, the metropolitan of Naupaktos c.1200-1232. It also seeks to evaluate how the result of this investigation may complement or revise our current knowledge of the silk industry in Byzantine Central Greece.
The Real Exchange Rate Policy Trilemma in Surplus-Labor Developing Economies
Authors: Razmi Arslan 
Published: April 2022

Abstract
This paper discusses some of the intertemporal political economy issues that arise in the pursuit of real undervaluation to achieve more rapid development. Policy makers face a trade-off between achieving a capital stock target in a given amount of time on the one hand and boosting real wages in the short-run, on the other. This generates a trilemma whereby development-focused policy makers can choose to pursue two out of three desirables: (1) use the real exchange rate as an instrument of development policy, (2) meet the development target within a politically relevant time frame, and (3) maintain political stability. The optimal path under a policy with “unambitious” aims will resemble the typical electoral business cycle trajectory whereby policy makers maintain real overvaluation over much of the cycle. By contrast, achieving ambitious capital stock/development targets within a relatively short time requires the potentially unpopular strategy of choosing a highly undervalued real exchange rate at the beginning of the planning horizon and gradually increasing the degree of undervaluation thereafter as wages rise. Relevant structural differences between countries imply different initial levels of real undervaluation, distinct optimal trajectories over time, and hence, varying degrees of trade-offs.
Primary hypertriglyceridemia induced pancreatitis in a cohort of Pakistani children
Authors: Khan Sabeen Abid , Khan Anusha , Malik Munir Iqbal 
Published: April 2022

Abstract

Objectives
Primary hypertriglyceridemia is a rare condition in children. Hypertriglyceridemia induced pancreatitis is most commonly reported in adults, accounting for third most common cause after gallstones and alcohol consumption. The study aims to highlight the frequency of hypertriglyceridemia induced pancreatitis in a cohort of children presenting in a tertiary care hospital.

Methods
A retrospective review of paediatric patients with pancreatitis was conducted in Shifa International hospital, Islamabad, from 2013 to 2020. All patients under 18 years of age who fulfilled the inclusion criteria were included. Medical records of patients were checked for symptoms, signs, age, growth parameters and laboratory investigations. Patients who had HTG were reviewed in detail for family history of pancreatitis or dyslipidemias.

Results
We found a cohort of 6 patients with primary hypertriglyceridemia after excluding secondary causes. Out of these 6 patients, 4 (66.6%) were male and 2 (33.3%) were female. Minimum age of our patient was 2 months and maximum was 17 years with a mean age of 6.5 years. Two patients presented less than one year of age. Mean triglyceride levels was 1,599 + 523 mg/dL. Four patients (66.6%) had acute pancreatitis, one each (16.6%) had recurrent and chronic pancreatitis. Family history was positive for hyperlipidaemia in two patients who had positive consanguinity. Patients with positive family history were symptomatic at earlier age.

Conclusions
This is the first study to highlight primary hypertriglyceridemia presenting as pancreatitis in paediatric population from Pakistan. All patients had triglycerides level of greater than 1000 mg/dL.
Congenital generalized lipodystrophy type 4 due to a novel PTRF/CAVIN1 pathogenic variant in a child: effects of metreleptin substitution
Authors: Adiyaman Suleyman Cem , v.Schnurbein Julia , De Laffolie Jan , Hahn Andreas , Siebert Reiner , Wabitsch Martin , Kamrath Clemens 
Published: April 2022

Abstract

Objectives
Congenital generalized lipodystrophies (CGLs) are a heterogeneous group of rare autosomal recessive disorders characterized by near/total absence of body fat. Pathogenic variants in polymerase-I and transcript release factor gene (PTRF), or CAVIN1, is responsible for CGL4. In addition to generalized fat loss, patients with CGL4 were reported to suffer from myopathy, malignant cardiac arrhythmias, gastrointestinal disorders, and skeletal abnormalities. Here we describe the phenotype of a child with CGL4 due to a rare, novel pathogenic variant in the PTRF/CAVIN1 gene and the long-term effects of metreleptin substitution on comorbidities.

Case presentation
We describe a now 20-year-old female patient. At the age of 14-years, she was referred to the University Clinic because of uncontrolled diabetes with an HbA1c of 9.3%, requiring 2.4 IU insulin/kg total-body-weight to normalize blood glucose, hepatomegaly, and hypertriglyceridemia of 515 mg/dL. Additionally, she was suffering from malignant cardiac arrhythmia, myopathy, and hyperCKemia. In light of these clinical findings, she was diagnosed with CGL due to a rare, novel variant in the PTRF gene, and was started on metreleptin, a synthetic analog of human leptin. After the initiation of metreleptin treatment, insulin therapy could be stopped and improvement of sonographically assessed liver size was observed, even though serum liver function test stayed mildly elevated. Furthermore, a noticeable improvement of the serum triglyceride levels was also seen. Medical care and regular follow-up visits are being carried out by a multi-disciplinary team.

Conclusions
Although CGL4 is rare, due to its life-threatening comorbidities and the opportunity for an early intervention, it is important that the clinicians should recognise these patients.
Mapping the Critical System: Kant and the Highest Good
Authors: Sweet Kristi 
Published: April 2022

AbstractThis essay considers Kant’s concept of the highest good from a systematic point of view. The two spheres of freedom and nature—of the practical and theoretical—need to be brought into a causal relation for the highest good to be achieved. Kant seems to offer numerous possibilities for how human beings are able to think that it is possible for the highest good to be attainable. I argue that it is only in the thirdCritique, however, that Kant articulates an answer that also establishes freedom and nature within a larger system. The thirdCritiquedoes this by positing a third, independent and mediating sphere of human experience that allows a transition between freedom and nature to be effected. This answer to the problem of the highest good is distinctive because the causal efficacy of reason in attaining its own demands is preserved. I examine Kant’s view by way of an analysis of his discussion of ‘territory’ and ‘domain’ in the Introduction to the text.
The Ultraviolet Bleach corpus
Authors: Knoblock Natalia , Malkin Ryan 
Published: April 2022

Abstract
This paper presents a new corpus of computer-mediated communication on the topic of Trump’s comments about household disinfectants and ultraviolet light as cures for COVID-19. The corpus, named the Ultraviolet Bleach (UVB) corpus, contains message board comments devoted to Trump’s suggestions. It was collected in May 2020 and consists of twenty-six files, with a total size of 2,344,164 word tokens. The paper includes frequency lists of words and clusters, keywords, and keywords in context, identified with the help of the corpus management software Sketch Engine. The corpus highlights the “receiving end” of political communication since it involves reactions to Trump’s televised briefing, and it will be of interest to researchers of political communication, populist and conspiratorial discourse, public opinion, and language aggression.