bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Topical Application of Honey in the Management of Radiation Induced Oral Mucositis
Authors: Patil Karthikeya , Sanjay CJ , Viveka S , Doggalli Nagabhushana , Aishwarya R 
Published: June 2022

Background and Objective:
Most patients with oral cancer receive chemoradiotherapy with or without surgery for treatment and develop oral mucositis, a debilitating adverse. Currently, there is no standard regimen for the management of radiation-induced mucositis. This study aims to evaluate the effect of honey on radiation-induced mucositis.

Methods:
The study consisted of 204 subjects of both genders, diagnosed and treated by radiotherapy for head and neck carcinoma and who had developed oral mucositis. The control group (n = 102) received 0.9% normal saline while the interventional group (n = 102) received honey as a topical application. Both groups were evaluated by the World Health Organization oral mucositis assessment scale at baseline (I visit) and four follow-up visits.

Results:
A decrease in the progression of the lesion and symptomatic relief were found in the interventional group. There was neither symptomatic relief nor a decrease in mucositis grade in the control group.

Conclusion:
Within the limits of this study, the results showed that the topical application of honey could be used to alleviate the symptoms in the management of radiation mucositis as it is easily available, simple, and economical.
Serum Lipid Profile and C-Reactive Protein as Prognostic Markers in Oral Submucous Fibrosis
Authors: Jayanthiswari K. , Manoharan G.V. Murali Gopika , Muthukumar S. 
Published: June 2022

Introduction:
Oral submucous fibrosis is a chronic, premalignant condition of the oral mucosa, affecting millions of people globally and it is one of the precancerous conditions most prevalent in India. Previously published studies have evaluated the serum lipid profile and C-reactive protein in various potentially malignant disorders and oral squamous cell carcinoma, but to our knowledge, no studies are available comparing the pre- and post-treatment serum lipid profile and C-reactive protein values in oral potentially malignant disorders, so that their real prognostic value can be assessed.

Aim:
The present study aims to evaluate the serum lipid profile and C-reactive protein as a prognostic marker in Oral Submucous Fibrosis patients.

Materials and Methods:
A total of 30 clinically diagnosed OSF patients of either gender in the age group of 20 – 50 years were selected. A complete history taking followed by a thorough oral examination was done on all patients. About 5 mL of blood sample was collected before treatment and after 6 weeks of treatment for estimation of serum lipid profile and C-reactive protein

Results:
The mean values of serum lipid profile were decreased among OSF patients and the difference between pre- and post-treatment was statistically significant. The comparison of the mean values of the pre- and post-treatment CRP level of the study subjects among OSF patients was found to be statistically significant (P = 0.022).

Conclusion:
Hence, pre- and post-treatment serum lipid profile and CRP levels contribute to being of prognostic value in OSF.
Introduction of a New Parameter 'Mastoid to Gonion Height' and its Comparative Evaluation with Established PA Cephalometric Parameters in Sex Determination
Authors: Sathawane Ramhari , Tripathi Samiksha , Sukhadeve Vidyarjan 
Published: June 2022

Introduction:
Skeletal remains have a vital role in the differentiation of sex in forensic studies. Skull is the second most sexed skeleton after the pelvis. PA cephalogram is more precise and provides numerous anatomic points and planes in the frontal profile for comparison.

Aim:
To introduce a new parameter 'Mastoid to Gonion height,' and compare its accuracy with established PA cephalometric parameters in sex determination using discriminant functions.

Materials and Methods:
A hundred males and females each aged 25 to 60 years were included. A total of eight planes were constructed on PA cephalograms and measured. The data were analyzed using discriminant analysis.

Results:
The linear measurements were found greater in males than females. Among the studied parameters, Bizygomatic width and Mastoid to Gonion height had a high sex discriminating ability. The discriminant function (DF) equation correctly predicted the gender in 88.5% of subjects.

Conclusion:
The new parameter “Mastoid to Gonion” height has been successfully introduced. It is found to be the second-best strong predictor parameter and can be used singly for sex determination. The parameter Bi-zygomatic width also contributed most significantly and can be used singly. The DF equation is proposed to predict new cases.
Quantitative Estimation of Anti-Spike SARS-CoV-2 IgG Antibody Response After Covishield Vaccination in Healthcare Workers
Authors: Goyal Megha , Jain Mayuri , Patel Nidhi , Sharma Alka 
Published: June 2022

Background:
Most studies of COVID vaccination focused on cell-mediated immunity and serum IgG antibodies, overlooking the role of anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) neutralizing IgA antibodies in preventing viral infection. SARS-CoV-2 vaccine generates variable Anti-Spike IgG responses following one or two vaccine doses in almost all individuals for protection.

Aim:
The study aimed to quantify and estimate the Anti-Spike SARS-CoV-2 IgG antibody response after the second dose of the Covishield vaccine in healthcare workers (HCWs) over the time frame of one, three, and six months.

Material and Methods:
30 HCWs who had received both doses of the Covishield vaccine were selected and divided into three groups based on the time elapsed after the second dose of vaccine for serological analysis. Post-vaccination antibody responses were measured using the SARS-CoV-2 IgG Quantitative assay (detection threshold: ≥50 AU/ml) using chemiluminescent microparticle immunoassay (CMIA). Data were analyzed using the Kolmogorov-Smirnov test, Kruskal-Walli's test, and Mann-Whitney U test.

Result:
Vaccination leads to measurable anti-spike IgG antibodies in HCWs. Only 1 individual was seronegative. The highest antibody titer was reported after one month of the second dose (3615.3 AU/ml). The lowest antibody titer (491.5 AU/ml) was seen after six months of the second dose of Covishield is statistically significant.

Conclusion:
Anti-Spike SARS-CoV-2 IgG antibody determination is necessary for an immune response after vaccination. This titer decreases with time consequently as the duration after the second dose of the Covishield vaccine increases. This helps assess the requirement of a booster dose for effective immunity against coronavirus.
Efficacy of Pulsed Short Wave Therapy in Symptomatic TMD Patients
Authors: Dhanasekaran Sadhurya M. , Kannan A. , Lakshmi Krithika C. , Anuradha G , Aniyan K Yesoda 
Published: June 2022

Context:
Temporomandibular joint (TMJ) is a ginglymoarthroidal joint of synovial variety. The joint's pathology includes those predominantly of musculoskeletal origin, which poses a complex problem in the clinical scenario. The management of temporomandibular joint disorders (TMD) remains a challenge due to the intricate anatomy of the joint and the multipart etiologies associated with it.

Aims:
This study aimed to compare the effectiveness of pulsed short wave therapy (PSWT) with pharmacotherapy in symptomatic TMD patients.

Methods and Material:
A total of 62 patients were included in this randomized control trial and were randomly allotted into two groups. Patients in Group I received PSWTand Group II received a combination of a muscle relaxant and a nonsteroidal anti-inflammatory drug (NSAID) for 5 consecutive days. Visual analog scale (VAS) scores were recorded during the follow-up.

Statistical Analysis Used:
The statistical analysis was performed using Stata/SE 17.0 statistical software.

Results:
There was a statistically significant difference in the groups for different periods. Kaplan–Meier function and extended survivor function tests showed better pain alleviation in the short wave therapy group.

Conclusion:
The current study shows that PSWT decreased pain without adverse effects. Therefore, it could be considered a safe and potentially effective adjuvant therapeutic modality for TMD.
Parental Transmission Effects of the PAX7 Polymorphisms among Non-Syndromic Cleft Lip Palate
Authors: Khan Mahamad Irfanulla , Prashanth C. S. , Mustak Mohammed S. , Nizamuddin Sheikh , Tejasvi Avinash 
Published: June 2022

Background:
Orofacial clefts (OFCs) are the most common congenital deformities in the human face, with a prevalence of around 1:800 to 1:1000 among the Indian population.

Aim:
To assess the Paired box 7 (PAX7) gene polymorphisms in the etiology of non-syndromic cleft lip and cleft palate (NSCL/P) in the Indian population using a case-parent trio design and to contemplate parent-of-origin effects.

Materials and Methods:
The study comprised forty case-parent trios of NSCL/P from the Indian population. Genomic deoxyribonucleic acid (DNA) was isolated from the cases and their parents. The polymorphisms rs6659735, rs553934, rs624761, rs609959, and rs4075768 of the PAX7 gene were genotyped using Agena Bio MassARRAY analysis. The transmission disequilibrium test (TDT) was performed using the PLINK software and the pairwise linkage disequilibrium analysis by the Haploview software.

Results:
The genotyping of the polymorphisms rs6659735, rs553934, rs624761, rs609959, and rs4075768 was done. We found a significant association of the rs6659735 (P-value = 0.03, Odds ratio = 4.5) with NSCL/P in the allelic frequencies of the Indian case-parent trios. In addition, the parent-of-origin effects were observed as the allelic TDT analysis showed a significant paternal transmission of the rs6659735 (P-value = 0.04), whereas the rs553934 (P-value = 0.04) showed an excess maternal transmission.

Conclusions:
The parent-of-origin effects were observed as the two polymorphisms demonstrated a significant parental transmission. The rs6659735 showed a significant paternal transmission, whereas the rs553934 showed an excess maternal transmission, suggesting that the PAX7 gene may influence the risk of NSCL/P in the Indian population.
Multiplicity one theorems over positive characteristic
Authors: Mezer Dor 
Published: June 2022

AbstractIn Aizenbud et al. (2010, Annals of Mathematics 172, 1407–1434), a multiplicity one theorem is proved for general linear groups, orthogonal groups, and unitary groups (
$GL, O,$
and U) over p-adic local fields. That is to say that when we have a pair of such groups
$G_n{\subseteq } G_{n+1}$
, any restriction of an irreducible smooth representation of
$G_{n+1}$
to
$G_n$
is multiplicity-free. This property is already known for
$GL$
over a local field of positive characteristic, and in this paper, we also give a proof for
$O,U$
, and
$SO$
over local fields of positive odd characteristic. These theorems are shown in Gan, Gross, and Prasad (2012, Sur les Conjectures de Gross et Prasad. I, Société Mathématique de France) to imply the uniqueness of Bessel models, and in Chen and Sun (2015, International Mathematics Research Notice 2015, 5849–5873) to imply the uniqueness of Rankin–Selberg models. We also prove simultaneously the uniqueness of Fourier–Jacobi models, following the outlines of the proof in Sun (2012, American Journal of Mathematics 134, 1655–1678).By the Gelfand–Kazhdan criterion, the multiplicity one property for a pair
$H\leq G$
follows from the statement that any distribution on G invariant to conjugations by H is also invariant to some anti-involution of G preserving H. This statement for
$GL, O$
, and U over p-adic local fields is proved in Aizenbud et al. (2010, Annals of Mathematics 172, 1407–1434). An adaptation of the proof for
$GL$
that works over of local fields of positive odd characteristic is given in Mezer (2020, Mathematische Zeitschrift 297, 1383–1396). In this paper, we give similar adaptations of the proofs of the theorems on orthogonal and unitary groups, as well as similar theorems for special orthogonal groups and for symplectic groups. Our methods are a synergy of the methods used over characteristic 0 (Aizenbud et al. [2010, Annals of Mathematics 172, 1407–1434]; Sun [2012, American Journal of Mathematics 134, 1655–1678]; and Waldspurger [2012, Astérisque 346, 313–318]) and of those used in Mezer (2020, Mathematische Zeitschrift 297, 1383–1396).
Zinc, Tin and Silver Porphyrins (TPP, TCPP, TMPP, THPP, TPPS, TMPyP) as photosensitizers in antibacterial photodynamic therapy for chronic wounds: A screening study
Authors: George Reama Chinedu , Torimiro Nkem , Daramola Oluwafemi Bamidele , Olajide Afusat Ajoke 
Published: June 2022

Continuous proliferation of bacteria in a wound delays its healing process, and could further extend to becoming a chronic wound infection. The effectiveness of different porphyrins as a photosensitizer in antibacterial photodynamic therapy for the inactivation of some wound-colonizing bacteria was studied as a screening experiment. Meso-tetra(4-methoxyphenyl) porphyrin, (TMPP), meso-tetra(4-hydroxyphenyl) porphyrin (THPP), meso-tetra(4-carboxyphenyl) porphyrin, (TCPP), meso-tetra(N-methyl-4-pyridyl) porphyrin, (TMPyP) were synthesized, each complexed with zinc, tin and silver. The in-vitro and photo-toxicity properties of the porphyrins and their complexes were assessed on some selected wound colonizing multi-drug resistant bacterial strains (Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, and Escherichia coli) using agar well diffusion method. Photo-toxicity of the compounds were investigated using a 100-Watt tungsten lamp while the in-vitro toxicity was carried out in the dark. The results were compared with previously reported work carried out by this group on meso-tetra(phenyl)porphyrin (TPP), meso-tetra(4-sulphonatophenyl) porphyrin, (TPPS) and their corresponding Zn, Sn and Ag complexes. Most of the porphyrins showed biocidal activities against three of the test isolates with an exception to Proteus sp. ZnTMPyP and ZnTHPP only showed photo-toxic activities against the four test isolates. While SnTHPP, ZnTPPS, ZnTCPP, and SnTCPP all exhibited both toxic and photo-toxic activities against all four bacterial isolates. The Ag-porphyrins had the poorest inactivation activity.
COVID-19 Pandemic and Volatility Persistence of the Nigerian Crude Oil Price
Authors: Samson T. K. , Raheem M. A. 
Published: June 2022

Impacts of COVID-19 pandemic on the global economy cannot be overemphasized, especially with Nigeria, which largely depends on crude oil as a major source of her revenue. Thus, investigating COVID-19’s impacts on the volatility persistence of Nigerian crude oil price forms the nucleus of this study. Our modelling framework was based on GARCH, EGARCH and GJR-GARCH with two asymmetric innovation distributions Daily price data on the Nigerian crude oil sales (in dollars per barrel), ranging from 4th Jan., 2010 to 27th May, 2021, were obtained from the Central Bank of Nigeria (CBN). To capture the impact of the pandemic, the data were divided into two periods, before Covid-19 was proscribed as a pandemic by World Health Organisation (01/04/2010 to 10/03/2020) and during COVID-19 pandemic (11/03/2020 to 27/05/2021). Result shows that the leverage effect were positive and significant in both periods which indicates that positive shocks increases volatility more than negative news of the same sign. Also, EGARCH-SSTD and GJR-GARCH (1,1)-SSTD were the best fitted models for before and during pandemic respectively. Result shows that volatility persistence was higher during COVID-19 period (1.012639) than before the COVID-19 pandemic (0.988749) .There was also an increase and over persistence in the volatility of Nigerian crude oil price during COVID-19 than before COVID-19 period.
Effects of Aqueous Extract of Moringa oleifera on Phenylhydrazine-induced Liver Toxicity in Wistar Rats
Authors: Obayuwana E. , Imafidon E. O. , Odiase D. E. , Alih O. J. , Nweke S. M. , Enoghase R. J. , Ndubuisi J. P. K. , Okpako R. A. 
Published: June 2022

Moringa oleifera has been shown to have a variety of medicinal benefits, including hepatoprotective effects. Phenylhydrazine has been used to cause hepatotoxicity in experimental models. In this study, an aqueous extract of Moringa oleifera was used to evaluate the ameliorating properties of phenylhydrazine-induced liver damage by assessing liver enzymes and histoarchitecture employing twenty-five (25) mature Wistar rats were divided into five (5) groups. Group A received 1 ml distilled water, Group B received 50 mg/kg phenylhydrazine twice in 48 hours, Group C received 500 mg/kg body weight of Moringa oleifera aqueous extract for four (4) weeks, Group D received 50 mg/kg phenylhydrazine twice in 48 hours and 500 mg/kg body weight of Moringa oleifera aqueous extract for four (4) weeks, and Group E received 50 mg/kg of phenylhydrazine twice in forty-eight (48) hours and 70 mg/kg body weight of Silymarin for four (4) weeks. After the administration of phenylhydrazine, significant increases (P<0.05) in the mean concentrations of liver enzymes (ALP, AST, ALT) and total protein were observed, whereas treatment with Moringa oleifera resulted in a reversal of those parameters to values comparable to the control and the standard drug - Silymarin. Overall, the results showed that Moringa oleifera aqueous extract had considerable hepatoprotective capability against phenylhydrazine-induced hepatotoxicity.
Evaluation of Repeat Analysis and Dose Burdens of Patients Examined in the Radiology Department of a Medical University Teaching Hospital in Nigeria
Authors: Fatukasi J. I. , Osho E. S. , Olowookere C. J. , Ogunsemoyin A. O. 
Published: June 2022

The objectives of this study was to examine the repeated examinations carried out and dose burdens of patients examined in the radiology department of a tertiary institution teaching hospital in Nigeria. A standard daily record keeping method (accepted and rejected films compiled by Radiographers) was used to collect data after viewing by a Radiologist. Raw data collected were sorted with the aid of Tally Chart. Descriptive statistics was employed to analyze the data collected with the help of Excel software. The specific repeat rates (SRRs) for different examinations are as follows: chest PA (CXR-6.68 %); lumbosacral (LS-10.90%); skull/head (S/H-15.08 %); abdomen (ABD-12.97 %); pelvis/hip (PE/H-7.77 %); cervical spine/neck (SP/NK-5.56 %); thoracic spine (TS-7.14 %); extremities (EXT-1.64 %); shoulder joint (SHJ-2.22 %); knee joint (KNJ-2.99 %); elbow joint (ELB-2.53 %); ankle joint (ANK-2.77 %); and hysterosalpingography (HSG-7.35 %). The highest causal reject rates (CRRs) was found to be as a result of under-penetration (34.3%) in this study. This is followed in succession by over-collimation (22.90 %) and processing artifact (20.50 %). The excessive population doses of the exposed patients resulting from repeats for some examinations are: chest PA (CXR-103.60 mGy); lumbosacral AP (LS-23.00 mGy); skull/head PA (S/H-71.10 mGy); abdomen AP (ABD-33.48 mGy); thoracic spine AP (TS-2.52 mGy); shoulder joint AP (SHJ-1.89 mGy); knee joint AP (KNJ-2.00 mGy); ankle joint AP (ANK-0.76 mGy); hysterosalpingography (HSG-1.95 mGy). The selected exposure parameters could also be examined and adjusted to prevent under-penetration.
Establishment and Validation of Continuously Operating Reference Stations Geosystems Network on Static and Real-Time Kinematic in Benin City, Nigeria
Authors: Oladosu S. O. , Ehigiator-Irughe R. , Muhammad M. B. M. E. 
Published: June 2022

An infrastructure highly treasured by Geomatics Engineers is the continuously operating reference stations (CORS). CORS technology is a complete paradigm shift from the previously known ground control system to a virtual control system. In this paper, we present the steps taken to install CORS Geosystems in Benin City and further test its efficacy by observing fifteen existing control points located far and near using two Tersus GNSS receivers (A&B) concurrently. We perform statistical adjustment using Trimble Business Center software. Successful adjustment took two (2) iterations with Chi square test at (95%) precision confidence level and degree of freedom being nine (9) showed that the result of the adjustment was reliable. Means of 0.007m, 0.003m 0.000m for Easting, Northings and Heights were obtained while the standard errors (σ) in E, N and H are 0.003m, 0.007m and 0.000m respectively. The achieved RMS errors obtained from the attempted validation confirmed further that the newly installed CORS is capable of providing reliable 3D geo-spatial data for prospective authorized users to proffer solutions to engineering, scientific, environmental and research driven challenges.
Protective Roles of Adansonia digitata (African Baobab), Cucumeropsis mannii (Melon), and Abelmoschus esculentus (Okro) Supplemented Diets against Cadmium-Induced Lipotoxicity, Bone Demineralization, and Cytotoxicity in Rabbits
Authors: Fatoki J. O. , Adekunle O. C. , Olorunfemi A. R. , Iyapo O. , Abdulrahim H. A. , Akintade B. B. , Adekunle A. S. 
Published: June 2022

The present study was undertaken to investigate the protective roles of Adansonia digitata (African baobab) Cucumeropsis mannii (Melon), Abelmoschus esculentus (Okro), on lipid profile, bone health, and selected organs (liver, kidney, brain, and testis) against cadmium-induced toxicity in rabbits. Twenty male rabbits were grouped into five with four rabbits in each group. Group 1 served as positive control and received standard feed and 1.5 mg/kg body weight normal saline, group 2 served as negative control and were exposed to 1.5 mg/kg body weight cadmium chloride, group 3 received 1.5 mg/kg body weight cadmium Adansonia digitata supplemented feed, group 4 received 1.5 mg/kg body weight cadmium chloride and Citrullus lanatus supplemented feed, while group 5 were given 1.5 mg/kg body weight cadmium chloride and Abelmoschus esculentus supplemented feed. All administrations were orally and lasted for 28 days. At the end of the administration, blood, liver, kidney, brain, and testes were harvested from the rabbits for biochemical and histological analysis. One-way analysis of variance followed by Turkey’s test was used to analyze the results with p < 0.05 considered significant. The results revealed that cadmium exposure caused a significant increase in serum total cholesterol, triacylglycerol, low density lipoprotein cholesterol concentration, and atherogenic index in rabbits exposed to cadmium. Cadmium exposure also reduced bone calcium concentration. Adansonia digitata maintained the atherogenic index of plasma at 2.67 compared with the positive control group (2.66). The three vegetables reversed the cadmium-induced up-regulation of total cholesterol and triacylglycerol in the liver, kidney, and brain but not in the testis. All the vegetables also restored bone calcium. Citrullus lanatus and Abelmoschus esculentus prevented organ damage induced by cadmium exposure. These vegetables however play different protective roles against cadmium exposed rabbits.