bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and exacerbation of autoimmune hemolytic anemia following COVID‐19 vaccination: A systematic review
Authors: Jafarzadeh Abdollah , Jafarzadeh Sara , Pardehshenas Mohammad , Nemati Maryam , Mortazavi Seyed Mohammad Javad 
Published: October 2022

AbstractAutoimmune hemolytic anemia (AIHA) is caused by the production of autoantibodies against RBCs. COVID‐19 vaccines can reduce the risk of severe disease, however, various adverse effects such as AIHA were observed following vaccination. This review aimed to assess the relationship of AIHA and COVID‐19 vaccination using the PRISMA guidelines. Among 18 cases included in this review, new post‐vaccination AIHA development was reported in 11 patients (7 women and 4 men) with a median age of 67.0 years. In 7 of 11 and 3 of 11 cases, the onset of symptoms occurred after first and second vaccine dose with median times of 7 and 14 days, respectively. In 1 of 11 cases, the AIHA occurred on Day 17 after booster vaccination. Ten of 11 and 1 of 11 AIHA patients received mRNA‐ and vector‐based vaccine, respectively. After vaccination, 9 of 11, 1 of 11, and 1 of 11 AIHA patients developed warm IgG, cold IgM, and mixed autoantibodies against RBCs, respectively. Significant AIHA exacerbation was reported in seven patients (four women and three men) with a median age of 73.0 years. In 4 of 7 and 2 of 7 exacerbated AIHA cases, the onset of symptoms occurred after first and second vaccine dose with median times of 7 and 3 days, respectively. In 1 of 7 exacerbated AIHA cases, the onset of symptoms was observed on Day 2 after booster vaccination. All exacerbated AIHA cases received mRNA‐based vaccines; 3 of 7 and 4 of 7 exacerbated AIHA cases developed IgG and IgM against RBCs, respectively. This review provides a comprehensive explanation regarding the AIHA development and exacerbation after COVID‐19 vaccination.
Novel efficient SrMgY3(SiO4)3F:Ce3+,Tb3+ phosphor with tunable color and thermal stability through energy transfer
Authors: Lu Zheng , Sun Dashuai , Lyu Zeyu , Shen Sida , Wang Lixuan , Wang Jianhui , Zhao Hanwei , You Hongpeng 
Published: October 2022

AbstractA novel apatite‐type SrMgY3(SiO4)3F was synthesized by a high‐temperature solid‐state reaction. The crystal structure was refined using powder X‐ray diffraction data. SrMgY3(SiO4)3F crystallizes in P63/m hexagonal space group with lattice parameters of a = b = 9.45270 Å, c = 6.77617 Å, and V = 524.357 Å3. The incorporation of the Ce3+ and Tb3+ ions into the matrix can generate bright blue and green lights under ultraviolet (UV) light excitation. The codoped Ce3+ and Tb3+ in SrMgY3(SiO4)3F can effectively improve green emission intensity and thermal stability through the energy transfer from the Ce3+ to Tb3+ ions. With the increase of Tb3+‐doping content, the luminescent color of phosphor changes from blue to cyan and finally to green. SrMgY3(SiO4)3F:0.06Ce3+,0.90Tb3+ phosphor exhibited intense green light emission with a quantum yield of 59.49% and good thermal stability, with an emission intensity at 150°C was 96% of that at 30°C. Finally, the prepared sample was coated on 365 nm UV chips to fabricate white light‐emitting diodes with a color rendering index of 82.6 and a correlated color temperature of 2912 K, demonstrating its potential for applications in display and lighting.
Atrial electrogram amplitude variability during atrial fibrillation ablation
Authors: Hangiel Urszula , Kuśnierz Jacek , Bardyszewski Aleksander , Dzwonkowska Dobromiła , Polańska‐Skrzypczyk Magdalena , Derejko Paweł 
Published: October 2022

AbstractIntroductionVariability of the bipolar atrial electrogram amplitude may affect voltage maps created during ablation procedures, and thus also the extent of ablations. Therefore, the aim of the study was to assess the beat‐to‐beat electrogram amplitude variability in the left atrium in patients undergoing atrial fibrillation ablation.MethodsIn 11 patients undergoing ablation for atrial fibrillation, 362 mapping points were collected in two series. At each point, three consecutive beats were recorded and verified including the bipolar electrogram amplitude, contact force (CF), and orientation of the catheter tip. The repeatability and reproducibility of obtained measurements between consecutive beats and series were assessed by the Pearson correlation coefficient (r), the Bland‐Altman test, repeatability coefficient (RC), relative standard deviation (RSD), and concordance correlation coefficient (CCC).ResultsA total of 1086 beats were analyzed. The correlation coefficient for bipolar atrial electrogram amplitude for the first two beats, and for the first and the third beats were 0.94 and 0.86, respectively. The average of differences between the first two beats and between the first and the third beats were 0.06 and 0.13 mV with 95% limits of agreement (LoA) within ±0.98 and ±1.74 mV, respectively. For CF values ≤5 and ≥20 g, the 95% LoA were narrower compared to other CF ranges and were ±0.49 and ±0.71 mV from the average value, respectively. When the analyzes were performed within the predefined ranges of bipolar electrogram amplitude: 0.05–1; 1–2; 2–3 mV, the 95% LoA were within ±0.33, ±0.98, and ±0.84 mV from the average value, respectively. RC and RSD were 1.41 mV and 20.8%, respectively. For repeated measurement between series, CCC ranged from 0.67 to 0.71 and the 95% LoA were within ±2.7 to 2.9 mV from the average value.ConclusionBipolar atrial electrogram amplitude recorded at a given site during ablation procedures is variable to an extent that may be clinically relevant. The magnitude of the observed variability is greater during remapping.
Phosphatase and tensin homologue determine inflammatory status by differentially regulating the expression of Akt1 and Akt2 in macrophage alternative polarization of periodontitis
Authors: Wu Xiaowei , Wang Yidi , Chen Haotian , Wang Yixiang , Gu Yan 
Published: October 2022

AbstractAimMacrophages are closely involved in periodontitis. However, the molecular mechanism by which macrophages influence periodontitis is not well understood. We investigated the effects of phosphatase and tensin homologue (PTEN) on macrophage polarization, the underlying mechanism and the regulatory roles in periodontium regeneration.Materials and MethodsPTEN expression in periodontitis macrophages was detected ex vivo. The effects of PTEN on macrophage polarization and the underlying mechanisms were investigated in vitro. We also analysed the ability of PTEN inhibitors to repair periodontitis in vivo in a ligature‐induced mouse model of periodontitis.ResultsMacrophage PTEN expression in periodontitis patients was significantly higher than that of controls. PTEN inhibition in macrophages induced alternative macrophage polarization, whereas PTEN overexpression facilitated classical polarization. PTEN inhibition facilitated activation of Akt1 while inhibiting expression of Akt2. Furthermore, Akt2 overexpression could rescue the effects of PTEN inhibition on NF‐κB. Treatment with a PTEN inhibitor significantly attenuated the local inflammatory status and prevented alveolar bone resorption in the mouse model.ConclusionsOur findings suggest that PTEN inhibition could induce alternative macrophage polarization by differentially regulating Akt1 and Akt2. This also changed a pro‐inflammatory microenvironment to an anti‐inflammatory environment by subsequently regulating the expression of NF‐κB, thereby attenuating inflammatory alveolar bone resorption induced by ligature.
CHH methylation of genes associated with fatty acid and jasmonate biosynthesis contributes to cold tolerance in autotetraploids of Poncirus trifoliata
Authors: Wang Yue , Zuo Lanlan , Wei Tonglu , Zhang Yu , Zhang Yang , Ming Ruhong , Bachar Dahro , Xiao Wei , Madiha Khan , Chen Chuanwu , Fan Qijun , Li Chunlong , Liu Ji‐Hong 
Published: October 2022

AbstractPolyploids have elevated stress tolerance, but the underlying mechanisms remain largely elusive. In this study, we showed that naturally occurring tetraploid plants of trifoliate orange (Poncirus trifoliata (L.) Raf.) exhibited enhanced cold tolerance relative to their diploid progenitors. Transcriptome analysis revealed that whole‐genome duplication was associated with higher expression levels of a range of well‐characterized cold stress‐responsive genes. Global DNA methylation profiling demonstrated that the tetraploids underwent more extensive DNA demethylation in comparison with the diploids under cold stress. CHH methylation in the promoters was associated with up‐regulation of related genes, whereas CG, CHG, and CHH methylation in the 3'‐regions was relevant to gene down‐regulation. Of note, genes involved in unsaturated fatty acids (UFAs) and jasmonate (JA) biosynthesis in the tetraploids displayed different CHH methylation in the gene flanking regions and were prominently up‐regulated, consistent with greater accumulation of UFAs and JA when exposed to the cold stress. Collectively, our findings explored the difference in cold stress response between diploids and tetraploids at both transcriptional and epigenetic levels, and gained new insight into the molecular mechanisms underlying enhanced cold tolerance of the tetraploid. These results contribute to uncovering a novel regulatory role of DNA methylation in better cold tolerance of polyploids.
The ubiquitin‐proteasome system in melanin metabolism
Authors: Shi Jingpei , Guo Yanfang , Wang Hanying , Xiao Yun , Liu Weimin , Lyu Lechun 
Published: October 2022

AbstractBackgroundThe ubiquitin‐proteasome system (UPS) is a highly conserved way of regulating intracellular protein balance. UPS mediates proteolysis and disruption of variation or misfolding, while finely regulating proteins involved in differentiation and other biological processes.AimsThe aim of this review is to systematically introduce UPS as a key regulator of melanin metabolism.MethodsSystematic search and retrospective review were performed on the published data.ResultsMelanocyte‐inducing transcription factor (MITF) is a substrate of the ubiquitin ligase VCHL1 and acts as a transcription factor to regulate the expression of key enzymes in melanin synthesis such as tyrosinase (TYR). The rate‐limiting enzyme TYR is modified by the ubiquitin ligase Hrd1 during melanosynthesis. Melanin itself is also regulated by multiple ubiquitin ligases including Fbp1 and Vhl. By regulating the ubiquitination modification to target each link of melanin synthesis, it plays an important role in correcting the disorder of melanin metabolism. A number of chemical agents have been proven to inhibit the activity of ubiquitin ligase.ConclusionsDrugs targeting E3 ligase and deubiquitinating enzymes have great potential in the treatment of melanin metabolism disorders.
Comparison of two devices for facial skin analysis
Authors: Cook Madison K. , Kaszycki Margaret A. , Richardson Irma , Taylor Sarah L. , Feldman Steven R. 
Published: October 2022

AbstractBackgroundThe use of quantitative measures to assess patients' skin has turned the subjective nature of dermatology into an objective one. These measures allow for more accurate diagnosis and improved monitoring of diseases. While there are many skin analysis devices available, they often require specific equipment to function and can be costly, limiting their clinical use.AimsThe aim of our study was to compare a new skin analysis device that is easy to incorporate into dermatologic practice to a standard validated device.MethodsWe recruited 50 patients from dermatology clinics and analyzed their skin with two facial analysis systems: an online application that can be downloaded on either an iPad or iPhone, and a computer‐based analysis system that utilizes a facial imaging photobooth. Scores were recorded and compared between the two devices for the following five skin characteristics; “spots,” “wrinkles,” “redness,” “texture,” and “pores.”ResultsThe tablet and the computer analysis system had an agreement rate of 67.7%. The highest agreement was in assessing texture (72.0%) and pores (68.2%). The lowest agreeance was in assessing redness (64%) and wrinkles (67%). When assessing the relationship between patients' raw score for wrinkles and their age, there was a strong correlation with the tablet (r = 0.79, p < 0.0001) compared with the computer system (r = 0.26, p < 0.06).ConclusionsThe application utilized in our study may serve as a cost‐effective and clinic friendly tool to assess patients' skin. It produces similar results to other skin analysis devices and may be more sensitive in detecting and quantifying wrinkles.
Filler‐based correction of tear trough depressions and eye bags in Japanese patients: A classification system and treatment algorithm
Authors: Kato Kiyoko , Kajiwara Tomoe , Furuyama Nobutaka , Liew Steven 
Published: October 2022

AbstractBackgroundTear trough depressions are widely treated with fillers. However, it is questionable whether the same strategies can always be used for Caucasian and Japanese patients, owing to differences in bone and skin structures and epithelial thickness.AimsTo assess a novel classification system and treatment algorithm for correcting tear trough depressions and eye bags in Japanese patients.MethodsTear trough depressions can be classified into three types according to the presence or absence of a “negative vector” based on retrusion of the maxilla relative to the anterior corneal surface, with or without eye‐bag protrusion when smiling. Type 1 patients (without the negative vector) can be treated simply by filling the depression in the tear trough and the palpebromalar groove region. Type 2 patients (with a negative vector and no eye‐bag protrusion on smiling) also require volume restoration in the mid‐cheek (deep medial cheek fat, suborbicularis oculi fat, and pre‐maxillary space); this not only enables volume recovery but also compensates for maxillary deficiency. Type 3 patients (with a negative vector and eye‐bag protrusion on smiling) require an additional step, based on placing a filler in front of the eye bags and pushing orbital fat backward.ResultsCase presentations demonstrate the utility of the techniques involved.ConclusionsThis system provides a simple and practical method for classifying and treating Japanese patients with tear trough depressions and eye bags. Further studies are warranted.
Does trigonelline help skin tone? Molecular docking studies of trigonelline on the human tyrosinase, formulation, optimization, and characterization of an emulgel‐containing Trigonella foenum‐graecum L. fenugreek standardized hydroalcoholic extract
Authors: Masjedi Moein , Solhjoo Aida 
Published: October 2022

AbstractAimsThis study aimed to perform molecular docking studies to identify possibilities of the inhibitory potential of the trigonelline present in fenugreek seeds on the human tyrosinase, standardize fenugreek extract, formulate, and characterize an emulgel‐containing fenugreek extract‐entrapped niosomal vesicles.Materials and MethodsThe docking study was performed using AutoDock software. The extract was standardized by the RP‐HPLC method. Emulgels containing fenugreek extract and fenugreek extract‐entrapped niosomes were optimized by the D‐optimal method. In vitro characterization and stability studies were also carried out.ResultsThe lowest energy docked poses of trigonelline on the human tyrosinase complex was calculated −5.8 kcal/mol. Also, in vitro assessment of the tyrosinase inhibitory effect of trigonelline and comparison of IC50 values of trigonelline and kojic acid revealed that the enzyme inhibition efficacy of trigonelline was stronger than that of kojic acid. Optimization led to emulgels with desired viscosity, droplet size, and spreadability values. The release study showed that trigonelline was released from the niosomes at a lower rate compared with extract containing emulgel. Permeation investigations revealed that trigonelline in niosomes has a higher ability to permeate through the skin.ConclusionIn conclusion, in silico and in vitro studies have shown that trigonelline can be assumed as an appropriate candidate for developing new cosmetic preparations and nonionic surfactant vesicles help trigonelline to permeate through the skin to a higher extent. However, clinical trials should be performed to confirm these findings.
Efficiency and safety of microneedling fractional radiofrequency in the treatment of Chinese atrophic acne scars: A retrospective study of 3 consecutive treatments with 1‐month intervals
Authors: Huang Linting , Liu Yang , Fang Wei , Liu Lanjun , Sun Qilin , Lin Xiaoxi , Xu Hui , Yang Yali 
Published: October 2022

AbstractBackgroundAtrophic acne scars (AAS) impact the aesthetic appearance, inducing social and psychological problems. Effective and safe therapy for AAS is urgently needed now. Microneedling fractional radiofrequency (MFRF) has emerged as a minimal invasive alteration for treating AAS lately, while the existing data on Chinese population was few.AimsWe aimed to explore the effectivity and safety of MFRF in Chinese patients with facial AAS and analyze the response of different subtypes to MFRF treatment.MethodsWe conducted a retrospective analysis using data from medical records and clinical photographs of 40 Chinese patients with AAS with Fitzpatrick skin type III‐IV, all of them had received 3 MFRF treatments with 1‐month intervals and were followed up 3 months after the last treatment. The clinical severity was assessed through échelle d'évaluation clinique des cicatrices d'acné (ECCA) score at each visit. Clinical photographs were taken by VISIA. Patients were asked to evaluate their satisfaction of the treatment using a 5‐point Likert scale at the last visit.ResultsECCA score decreased more than a half at the last visit based on the baseline. Among the three types of AAS, the M‐shaped scars respond most quickly to MFRF and the U‐shaped scars improved the most after 3 months follow‐up. A significant improvement was seen in clinical appearance, parallel to the change of ECCA, indicating the remarkable improvement of AAS after the MFRF treatment. Concomitant active acne was controlled along with the improvement of AAS. Statistics from VISIA showed excellent improvement in pores and texture as well. Side effects including pain and erythema were transient and mild. The number of MFRF treatment sessions was positively associated with the degree of improvement. Of the total 39 patients who had given a score of satisfaction, more than 89% (35 patients) were very satisfied or satisfied with the outcome.ConclusionsTo sum up, our study reveals that MFRF provides high efficiency in treating Chinese AAS patients with high satisfaction and low risk of adverse effects. M‐shaped scars are the most sensitive type to the treatment, but the U‐shaped scars improve most at the last visit. The simultaneous minimization of pores and improvement of skin texture imply the increased collagen stimulated by MFRF. Regular MFRF should be considered a good choice in treating AAS.
The efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of striae distensae: A randomized controlled trial
Authors: Suwanchinda Atchima , Nararatwanchai Thamthiwat 
Published: October 2022

AbstractBackgroundAvailable current therapeutics modalities for striae distensae (SD) provide inconsistently effective outcomes. There is ongoing research on innovative treatment modalities to find better treatment solutions.ObjectivesTo evaluate the efficacy and safety of innovative cold atmospheric plasma (CAP) technology in the treatment of striae distensae.MethodsThis study includes twenty‐three patients with striae distensae. The body was divided into two halves. One side was randomly treated with CAP biweekly on the same treated side for five sessions with 30 days follow‐up after the last session. Another half was left untreated. Efficacy assessment was done using patient and observer scar assessment scale (POSAS), patient satisfaction scales, and Antera 3D® skin imaging system. Safety assessment was evaluated using the visual analog scale (VAS) and adverse effects monitoring.ResultsPatient and observer scar assessment scale, patient and observer overall opinion score, and patient and observer total score in a summary of all rated characteristics, comparing treated and untreated areas, showed a statistically significant reduction in all parameters after one treatment (*p‐value <0.05). Patients rated satisfaction as a great improvement in 52.3%, moderate improvement in 39.1%, extreme improvement in 4.3%, and slight improvement in 4.3%. Adverse effects included small scabs, shallow wounds, and rash.ConclusionCold atmospheric plasma is a safe and effective, innovative treatment modality for striae distensae with minimal side effects.
Clinical application of brain perfusion imaging in detecting stroke mimics: A review
Authors: Khalili Neda , Wang Richard , Garg Tushar , Ahmed Amara , Hoseinyazdi Meisam , Sair Haris I. , Luna Licia P. , Intrapiromkul Jarunee , Deng Francis , Yedavalli Vivek 
Published: October 2022

AbstractStroke mimics constitute a significant proportion of patients with suspected acute ischemic stroke. These conditions may resemble acute ischemic stroke and demonstrate abnormalities on perfusion imaging sequences. The most common stroke mimics include seizure/epilepsy, migraine with aura, brain tumors, functional disorders, infectious encephalopathies, Wernicke's encephalopathy, and metabolic abnormalities. Brain perfusion imaging techniques, particularly computed tomography perfusion and magnetic resonance perfusion, are being widely used in routine clinical practice for treatment selection in patients presenting with large vessel occlusion. At the same time, the utilization of these imaging modalities enables the opportunity to better diagnose patients with stroke mimics in a time‐sensitive setting, leading to appropriate management, decision‐making, and resource allocation. In this review, we describe patterns of perfusion abnormalities that could discriminate patients with stroke mimics from those with acute ischemic stroke and provide specific case examples to illustrate these perfusion abnormalities. In addition, we discuss the challenges associated with interpretation of perfusion images in stroke‐related pathologies. In general, perfusion imaging can provide additional information in some cases—when used in combination with conventional magnetic resonance imaging and computed tomography—and might help in detecting stroke mimics among patients who present with acute onset focal neurological symptoms.
Magnifying inequality: How Black women found safety in the midst of dual pandemics
Authors: Geyton Taylor A. , Town Matthew , Hunte Roberta , Johnson Nia 
Published: October 2022

AbstractIn 2020, COVID‐19 in tandem with racial tensions spurred by various occurrences throughout the nation proved detrimental to minoritized persons. Black women, who are often the heads of households, familial and communal caregivers, and organizers, were tasked with protecting themselves, their families, and their communities from racialized violence and infection. This article explores the idea of safety and the responsibilities of Black women to ensure, secure, and maintain safety. The intersection of these two forces creates dual inequities. Whether sacrificing safety for the sake of racial equality or experiencing medical racism while seeking treatment for COVID‐19, the duality of Being black and a woman during two prevalent threats exacerbate existing inequities. Using symbolic interactionism to illustrate the function of structures and roles in defining Black women's positionality and intersectionality to examine the policies and systems that act on the lives of these women, we discuss the ways in which Black women created safety for themselves and their families at the intersection of both threats emphasizing the inequity in home, health, and financial outcomes among Black women.