bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Characteristic Response of the Human Leukocyte Transcriptome to 60 Days of Bed Rest and to Reambulation
Authors: STRATIS DANIEL , TRUDEL GUY , ROCHELEAU LYNDA , PELCHAT MARTIN , LANEUVILLE ODETTE 
Published: October 2022

ABSTRACT

Introduction
We sought to isolate the microgravity effect of spaceflight from other space stressors by characterizing the leukocytes’ transcriptome of participants to a 60-d bed rest study; an Earth model of microgravity.

Methods
Twenty healthy men received a nutritional supplement or not and 10 blood samples were collected throughout three study phases: baseline data collection (BDC) (BDC-12, BDC-11), head-down tilt (HDT) bed rest (HDT1, HDT2, HDT30, HDT60), and reambulation (R1, R2, R12, R30). We measured gene expression through RNA sequencing of leukocytes, applied generalized linear models to assess differential expression followed by enrichment analysis to identify temporal changes (model 1) and to measure the impact of a nutritional supplement (model 2).

Results
Baseline transcriptomes included 14,624 protein-coding transcripts and showed both high intraindividual correlations (mean Kendall coefficient, 0.91 ± 0.04) and interindividual homogeneity (0.89 ± 0.03). We identified 2415 differentially expressed protein-coding transcripts grouping into six clusters (C1–C6). At phase transitions, clusters showed either a decrease-then-increase (C3 and C5) or an increase-then-decrease (C1, C2, C6) pattern. All six clusters converged toward average expression at HDT30 and HDT60. Gene ontology terms at baseline related to immune functions while in bed rest and reambulation related to sequestration of ions, immune response, cellular stress, and mineralization. The nutritional intervention had no effect.

Conclusions
The temporal profiles of leukocytes’ transcriptomes emphasized the dynamic nature of gene expression occurring during and after bed rest. Enriched biological processes among the differentially expressed genes included immune related and unrelated responses. The convergence toward no differential expression at days 30 and 60 of bed rest suggests a hypometabolic state. Current findings can guide future work on the complex responses and adaptation mechanisms to microgravity.
An exploration of prenatal breastfeeding self-efficacy: a scoping review protocol
Authors: McGovern Liz , Geraghty Aisling , McAuliffe Fionnuala , O'Reilly Sharleen 
Published: October 2022

Objective: To synthesise the evidence on prenatal breastfeeding self-efficacy, including identifying concepts and theoretical frameworks that underpin its development, the evidence on its measurement, interventions used to improve it, and association with breastfeeding outcomes. Background: Breastfeeding self-efficacy is described as a woman’s self-belief and confidence in her perceived ability to breastfeed. It is a modifiable measure that is strongly associated with breastfeeding outcomes such as initiation, exclusivity, and duration. Interventions aimed at increasing self-efficacy are often in the postnatal period and have been shown to be effective at improving breastfeeding outcomes. The prenatal period appears to be underexplored in the literature and yet focusing on enhancing it may have the potential for further improvements in self-efficacy and on subsequent breastfeeding outcomes. A comprehensive knowledge synthesis on prenatal breastfeeding self-efficacy is lacking. Methods: The search will include databases across health, psychology, sociology, and the grey literature on breastfeeding guidance. Once the PCC framework (Problem: breastfeeding, Concept: self-efficacy, Context: prenatal period) is met, sources of evidence from any contextual setting will be eligible for inclusion. Limits will not be applied on geographic location or year of publication. The PRISMA-ScR flow diagram of search and study selection will be used to report final figures. Two independent reviewers will perform title and abstract screening, full-text review, and data extraction. Data will be charted to provide a logical and descriptive summary of the results that align with the objectives. Conclusion: The results will provide an understanding of what has been done in the space and what gaps exist, informing recommendations for the timing of measurement and the design of prenatal interventions.
Foveated 3D range geometry compression via loss-tolerant variable precision depth encoding
Authors: Schwartz Broderick S. , Finley Matthew G. , Bell Tyler 
Published: October 2022

The capacity of three-dimensional (3D) range geometry acquisition
methods to capture high-precision scans at high frame rates increases
every year. These improvements have influenced a broadening range of
disciplines to implement 3D range geometry capture systems, including
telepresence, medicine, the visual arts, and many others. However, its
increased popularity, precision, and capture rates have caused
mounting pressure on the storage and transmission of 3D range
geometry, thus straining their capacities. Compression techniques seek
to alleviate this pressure by offering reduced file sizes, while
maintaining the levels of precision needed for particular
applications. Several such compression methods use sinusoidal
modulation approaches to encode floating-point 3D data into
conventional 2D red, green, and blue (RGB) images. In some
applications, such as telepresence, high precision may only be
required in a particular region within a depth scan, thus allowing
less important data to be compressed more aggressively. This paper
proposes a feature-driven compression method that provides a way to
encode regions of interest at higher levels of precision while
encoding the remaining data less precisely to reduce file sizes. This
method supports both lossless and lossy compression, enabling even
greater file-size savings. For example, in the case of a depth scan of
a bust, an algorithmically extracted bounding box of the face was used
to create a foveated encoding distribution so that the facial region
was encoded at higher precisions. When using JPEG 80, the RMS
reconstruction error of this novel, to the best of our knowledge,
encoding was 0.56 mm in the region of interest, compared to a
globally fixed higher precision encoding where the error was
0.54 mm in the same region. However, the proposed encoding
achieved a 26% reduction in overall compressed file size compared to
the fixed, higher-precision encoding.
Discovery and validation of circulating miRNAs for the clinical prognosis of severe dengue
Authors: Limothai Umaporn , Jantarangsi Nattawat , Suphavejkornkij Natthasit , Tachaboon Sasipha , Dinhuzen Janejira , Chaisuriyong Watchadaporn , Trongkamolchai Supachoke , Wanpaisitkul Mananya , Chulapornsiri Chatchai , Tiawilai Anongrat , Tiawilai Thawat , Tantawichien Terapong , Thisyakorn Usa , Srisawat Nattachai 
Published: October 2022

BackgroundEarly prognostic markers of severe dengue may improve case management and reduce dengue-related mortalities. This study aimed to identify circulating microRNAs (miRNAs) as biomarkers for predicting severe dengue.MethodologySerum samples from dengue-infected patients were collected on the first day of admission. Patients were followed up for 14 days after admission to determine the final diagnosis. Participants were divided into non-severe and severe dengue, as defined by WHO 2009 criteria. Circulating microtranscriptome analysis was performed using NanoString miRNA Expression Assay. The expression level of candidate miRNAs were then validated by quantitative reverse transcription-PCR method.Principal findingsThe discovery cohort (N = 19) lead to the identification of 37 differentially expressed miRNAs between the two groups. Six up-regulated candidate miRNAs were selected and further validated in the larger cohort (N = 135). MiR574-5p and miR1246 displayed the highest diagnostic performance in discriminating between severe from non-severe dengue (ROC-AUC = 0.83). Additionally, miR574-5p and miR1246 had high sensitivity and high negative predictive value for detecting severe dengue. Multivariate analysis suggested that serum miR574-5p was an independent predictor of severe dengue (odds ratio 3.30, 95% CI 1.81–6.04;p<0.001).ConclusionOur study indicated that circulating miRNAs, especially miR-574-5p and miR-1246, might be a promising diagnostic and prognostic biomarker for severe dengue upon hospital admission, especially when using these biomarkers on days 1 to 2 before the onset of severe dengue complications.
Challenges and barriers to e-learning experienced by trainers and training coordinators in the Ministry of Health in Saudi Arabia during the COVID-19 crisis
Authors: Al Shamari Dalil 
Published: October 2022

IntroductionThe sudden shutdown caused by coronavirus disease 2019 has far-reaching effects, including on education and training. For this reason, traditional education and training have shifted to an online learning format. This study explores the challenges of and barriers to e-learning experienced by trainers and training coordinators in the Saudi Ministry of Health during the coronavirus disease 2019 pandemic.MethodsA cross sectional survey was distributed among participants by email. The sample included 262 trainers and training coordinators currently working for the Saudi Ministry of Health in hospitals, primary health care centers, and training centers (including general directorates of regions and clusters) in all 13 administrative regions of the country.ResultsMost participants exhibited an intermediate level of experience with e-learning (58.4%) and found the task of adapting to unfamiliar technology to be a challenge (22.1%). Limited social interaction in relation to cheating/plagiarism contexts, frequent technological failures, and a lack of policies or standards for e-learning were significant barriers for participants; these were mentioned by 46.9%, 43.5%, and 40.1% of participants, respectively.ConclusionsThis study highlights the challenges and barriers encountered in the adoption of e-learning by trainers and training coordinators in the Saudi Ministry of Health. The challenges of and barriers to e-learning included but were not limited to communication, assessment of trainees, adaptation to a lack of policy, and frequent technology failure. Adapting to new technologies is challenging for trainers and training coordinators, which is exacerbated by a lack of adequate policies and standards to eliminate cheating and avoid technological failures. These results could help bridge gaps in the use of e-learning by improving policies, holding workshops and training sessions, and providing continuous information technology support in e-learning.
Migrant Identity in Partir Written by Tahar Ben Jelloun
Authors: Allien Astri Adriani 
Published: October 2022

Partir, a novel by a francophone writer, Tahar Ben Jelloun tells about a Marocco man, Azel, who has a strong willingness to go out of his country. One of the countries he visited is Spain. Compared to other countries, Spain is the closest to Tangier, the city where Azel comes from. This paper aims to analyze the identity of immigrants as represented by Azel, the main character of Partir, by using a postcolonial approach. Azel’s relationship with Miguel, as the representation of the West, shows that there is a sharp distinction concerning the view that the West is the superordinate, and the East, as the subordinate. Even though the colonialism period has been over, the domination of the West over the East has been still going on under different levels of periods. Key words: immigrant, identity, colonialism, superiority.
Deixis Analysis in First Chapter of The Rainbow Troops Novel: Ten New Students by Andrea Hirata
Authors: Saputri Lenggahing Asri Dwi Eko 
Published: October 2022

One of the subjects that learn about language that can help human in using it is pragmatics. Pragmatics is the study of contextual meaning. Therefore, there must be a relationship between language and the context. The most obvious way to reflect the relationship between language and context is through deixis. Deixis is derived from the Greek word means pointing. There is no a language event without deixis or without any deictic expressions. A language event without such terms could not serve the communicative needs of its users anything like as well as a real human language. In this mini research, I chose to analyze an Indonesian novel entitled “Laskar Pelangi” (The Rainbow Troops) written by Andrea Hirata which had been translated in English by Angie Kilbane because in a novel there must be a context that surrounds the language. Moreover, in the context and the language there must be deixis between them to make the novel cohesive, coherent and acceptable for the reader. Therefore, a novel is a good material to be analyzed in finding the deixis. Based on some elaborations above, I can conclude that the use of deixis in The Rainbow Troops novel written by Andrea Hirata in 2009 need to be analyzed in the term of what types of deixis used in the novel and what the dominant type of deixes used in the novel. Keywords:pragmatics; deixis; Indonesian novel
Japanese and Javanese Directive Forms: A Study in Sociolinguistics
Authors: Santoso Teguh 
Published: October 2022

Abstract This paper is based on a study on directive forms in Japanese and Javanese Languages. The study combines a qualitative and sociolinguistically informed comparative method. The data were taken from different sources, namely Shin Suikodenand Jin (a Japanese novel and play respectively), Ketoprak Wiswakarman (a traditional Javanese play), and Panjebar Semangat (a Javanese magazine), and were then analyzed from a contrastive linguistic perspective. Theories on Japanese and Javanese descriptive sentences, namely those of Ishii,[1] Masuoka,[2] Poedjosoedarmo,[3] Sasangka,[4] and Wedhawati,[5] were used. In addition, Sudaryanto’s,[6] descriptive method, Sanada’s,[7] concept of Sociolinguistics, as well as Tarigan’s,[8] Ishiwata and Takahashi’s,[9] theories of contrastive linguistics were also consulted. The study aimed to describe the similarities and differences between Japanese and Javanese directive sentences based on the data from the dialogs. The study concludes that the speech levels used by the addressers and addressees in the Japanese dialogs are those of futsuugo and teineigo, which are comparable to those of ungguh-ungguh ngoko and ungguh-ungguh madya/krama in the Javanese dialogs. Keywords: directive; request; Japanese; Javanese; Sociolinguistics
Negotiation in A. Fuadi’s Ranah Tiga Warna (The Land of the Three Colors)
Authors: Wulandari Retno 
Published: October 2022

Travel writing is one of the literary genres that has received attention today. This paper discusses the work of A. Fuadi’s Ranah Tiga Warna (The Land of the Three Colors) telling the main character’s experience in three lands: Bandung (Indonesia), Amman (Jordan), and Saint Raymont (Canada). This paper is to analyze the negotiation process between ‘the self’ and ‘the other’ experienced by the main character in the third land: Saint Raymont. This uses the concept of negotiation of ‘the self’ and ‘the other’ by Thompson, and Deleutze’s and Guattari’s segmentarity. The results show that the main character can play a flexible interplay between ‘the self’ and ‘the other’, negotiation and accommodation, and even transduction. The successful negotiation process can be seen from the difference and how the main character has willingness to bring the difference to his home country. The main character’s mention of ‘return home’ when revisiting Saint Raymond years later becomes the evidence of the successful negotiation as well.Keywords: travel writing, negotiation, the self, the other
Language Maintenance Through Comic Strips
Authors: Savitri Ayu Ida 
Published: October 2022

AbstractLanguage, both spoken and written, is an evidence of human civilization as it tells the culture of its users. A language extincts when its speakers were also gone without passing it into their future users. Or else, their descendants shift their language to another so that the previous one is no longer used. The extinction of many indigenous languages in Indonesia shows that their users choose to use another languages that give them more benefit than those indigenous languages. For example, instead of using indigenous languages as their mother tounge, Javanese people choose Indonesian (the official language) or even English (the international language) as their first language. Language maintenance is then needed to do to preserve the languages and the culture embedded in its use. One of the ways to do it is by using it through mass media since they have strong influence toward people. This research describes indigenous language maintenance through printed mass media, particularly through comic strip on newspaper, tabloid and magazine. Comic strip is one of the sections in printed media, usually newspaper, using spoken language written on its panel that sometimes using part of indigenous language in the conversation of its characters. The writer shows how and comic strips at printed mass media indirectly preserve spoken Javanese.
Happy Birthday: Form and Function of Language
Authors: Chandra Oktiva Herry 
Published: October 2022

This article tells about the structure of greeting discourse, how people think about it and its function in social interaction.One of language functions is to tighten solidarity among members of a community. This can be done by using some expressions that show a positive intention of speaker to hearer. Saying congratulation to someone who has this special moment, such as birthday celebration, is one way to realize this function. When doing so, s/he is not only expressing her/his true feeling. Behind it, that expression represents diverse perception and value owned by people who produce and inteprete them. The data were collected form the conversationcontained in WA mobile application. They are taken from two groups, namely Semarak Juring and Dosen dan Tendik. The method of non-participatory participation was used and was followed by note taking technique. The result shows that the different representation of birthday greeting indicates various social relation between addresseer and addressee. This representation also marks differentfunctions of birthday greetings Keywords: form,function, social function, sympathy and respect .
Paradox of Life, Liberty and the Pursuit of Happiness in Guns N’ Roses “Civil War”
Authors: Laksono Arido 
Published: October 2022

The United States of America has long been known as the pioneer of freedom and democracy. The country promotes the idea of acquiring self-fulfillment without interfering others. Man can have his freedom upon life, liberty and the pursuit of happiness given to him ever since he was born. The long history of the United States of America recorded events and tumults testing the loftiness of American Dream. One of the American rock bands portraying the aforementioned situation is Guns N’ Roses. The lyric of “Civil War” clearly describes the paradox of life, liberty and the pursuit of happiness. Protest against war was increasing. Thus, the waves of strike and demonstration occurred as critics toward Government policy. At this point, rock bands also have important roles in accommodating people’s hopes and wishes. By using several elements of poetry, an argumentative analysis is developed and elaborated in order to reveal the attitude of people regarding government policy on war.. Keywords: Paradox; War, Government policy; Guns N’ Roses;
Killing Guiltlessly as Reaction of Sadistic Personality Disorder in Euripides’ Medea (A Psychological Approach in Literature)
Authors: Hadiyanto Hadiyanto 
Published: October 2022

ABSTRACT This research paper is aimed at analyzing one of Euripides’ well-renowned classical literary works entitled Medea by focussing on Medea as the main character of the story, Medea’s psychological state, psychological reason, and sadistic personality disorder reaction. This research paper uses psychological approach in analyzing the related psychological phenomena in Euripides’ Medea. The resut of the research indicates that Medea, who gets accustomed to being raised in a barbarous family and living in a barbaric environment, has a natural impulsive behaviour to kill other persons guiltlessly. Key words: killing, guiltless feeling, sadistic personality disorder
IUPAC Top Ten Emerging Technologies in Chemistry 2022
Authors: Gomollón-Bel Fernando 
Published: October 2022

Abstract
In 2019, IUPAC launched the “Top Ten Emerging Technologies in Chemistry Initiative.” [1] This project, nowadays consolidated and recognised by experts worldwide, highlights the value of chemical sciences in the transition to a green economy and a more sustainable world, in line with the United Nations’ Sustainable Development Goals (SDGs) [2]. Moreover, in 2022 we join the celebration of the International Year of Basic Sciences for Sustainable Development (IYBSSD), a United Nations (UN) resolution to reaffirm and emphasise the importance of basic sciences, chemistry among them, to attain the ambitious SDGs by 2030.
Controlled optical near-field growth of individual free-standing well-oriented carbon nanotubes, application for scattering SNOM/AFM probes
Authors: Yazdanfar Payam , Heydarian Hesam , Rashidian Bizhan 
Published: October 2022

Abstract
Exploiting localized heat-generation density and the resulting enhanced temperature-rise for controlled growth of carbon nanotubes (CNTs) is reported, and its potentials for batch-production of high-quality CNT probes are demonstrated. Optical near field chemical vapor deposition (ONF-CVD) benchtop fabrication schemes are developed for the localized integration of individual well-aligned carbon nanotubes without bending/buckling exactly at desired nanoscale sites. It is demonstrated that generating self-aligned catalyst nanoparticles superimposed on top of silicon nanotips, along with near-field induced absorption confinement, provide the ability to localize the generated heat at the nanotips apexes, and control the CNT growth locations. The nanoscale maskless controllability of the growth site is shown by properly tailoring ONF-CVD conditions to overcome overall heat exposure of the substrate for selective activation of catalyst nanoparticles located at apexes, from those dispersing all over the tips. The calculated local power densities and temperature profiles of the simulated tips, clearly demonstrate the confined heat and optimal gradient of generated temperature rise as the main factors affecting the growth. In addition to determining necessary processing conditions to control the localization and orientation of the growth, parameters affecting the length and diameter of the localized individually grown nanotubes are also presented. Optical near-field-based growth schemes can be extended for localized maskless fabrication of other nanoscale devices, beyond the diffraction limit, using photothermal effects.