bluuebunny/crossref_metadata_2025_split huggingface dataset:
Familiarity Deficits for Words and Objects in Amnestic Mild Cognitive Impairment in a Context Minimizing the Role of Recollection
Authors: Sanger Brahm D , Anderson Nicole D 
Published: May 2022

Abstract

Objectives
Amnestic mild cognitive impairment (aMCI) is associated with cortical thinning in perirhinal and entorhinal cortices, key regions of the brain supporting familiarity. Individuals with aMCI demonstrate familiarity deficits in their behavior, often repeating questions in the same conversation. While familiarity deficits in healthy aging are minimal, past studies measuring familiarity in aMCI have mixed results, perhaps due to the influence of recollection. We therefore used a paradigm that minimized the influence of recollection, and hypothesized that familiarity would be impaired in aMCI relative to age-matched controls, but not in healthy older adults relative to younger adults. We also hypothesized that familiarity deficits in aMCI would be greater for objects than words because the perirhinal cortex plays a significant role in visual discrimination.

Methods
A sample of 36 younger adults, 38 cognitively intact older adults, and 30 older adults with aMCI made absolute frequency judgments for words and objects seen a variable number of times in an incidental encoding task. Estimates of familiarity were derived from correlating participants’ frequency judgments with the actual frequency of presentation.

Results
Familiarity was largely spared in healthy aging, with minor deficits in familiarity for words. Familiarity deficits were evident in aMCI comparably for words and objects.

Discussion
The present research underscores the need to study familiarity in contexts minimizing recollection, particularly when comparing groups with different levels of recollection, and adds to our understanding of the phenomenology of aMCI. Familiarity deficits may provide an early biomarker of dementia risk.
Dirac Series of GL(n, ℝ)
Authors: Dong Chao-Ping , Wong Kayue Daniel 
Published: May 2022

Abstract
The unitary dual of $GL(n, {\mathbb {R}})$ was classified by Vogan in the 1980s. In particular, the Speh representations and the special unipotent representations are the building blocks of the unitary dual with half-integral infinitesimal characters. In this paper, we classify all irreducible unitary $({\mathfrak {g}}, K)$-modules with non-zero Dirac cohomology for $GL(n, {\mathbb {R}})$, as well as a formula for (one of) their spin-lowest $K$-types. Moreover, analogous to the $GL(n,{\mathbb {C}})$ case given in [12], we count the number of the FS-scattered representations of $GL(n, {\mathbb {R}})$.
Evaluation of essential fatty acids in lactating sow diets on sow reproductive performance, colostrum and milk composition, and piglet survivability
Authors: Holen Julia P , Woodworth Jason C , Tokach Mike D , Goodband Robert D , DeRouchey Joel M , Gebhardt Jordan T , DeDecker Ashley E , Martinez Xochitl 
Published: May 2022

Abstract
Mixed parity sows (n = 3,451; PIC, Hendersonville, TN; parities 2 through 9) and their litters were used to evaluate the effects of essential fatty acid (EFA) intake on sow reproductive performance, piglet growth and survivability, and colostrum and milk composition. Our hypothesis, like observed in earlier research, was that increasing linoleic acid (LA) and α-linolenic acid (ALA) would improve sow and litter performance. At approximately day 112 of gestation, sows were randomly assigned within parity groups to 1 of 4 corn–soybean meal–wheat-based lactation diets that contained 0.5 (Control) or 3% choice white grease (CWG), 3% soybean oil (SO), or a combination of 3% soybean oil and 2% choice white grease (Combination). Thus, sows were provided diets with low LA and ALA in diets with CWG or high LA and ALA in diets that included soybean oil. Sows received their assigned EFA treatments until weaning and were then fed a common gestation and lactation diet in the subsequent reproductive cycle. Average daily feed intake during the lactation period increased (P &lt; 0.05) for sows fed the Combination and CWG diets compared with sows fed the Control or SO diet. However, daily LA and ALA intakes of sows fed the Combination and SO diets were still greater (P &lt; 0.05) than those of sows fed 0.5 or 3% CWG. Overall, sows consuming high EFA from the Combination or SO diets produced litters with heavier (P &lt; 0.05) piglet weaning weights and greater (P &lt; 0.05) litter ADG when compared with litters from sows fed diets with CWG that provided low EFA. Despite advantages in growth performance, there was no impact of sow EFA intake on piglet survivability (P &gt; 0.10). Additionally, lactation diet EFA composition did not influence sow colostrum or milk dry matter, crude protein, or crude fat content (P &gt; 0.10). However, LA and ALA content in colostrum and milk increased (P &lt; 0.05) in response to elevated dietary EFA from SO. There was no evidence for differences (P &gt; 0.10) in subsequent sow reproductive or litter performance due to previous lactation EFA intake. In conclusion, increased LA and ALA intake provided by soybean oil during lactation increased overall litter growth and pig weaning weights, reduced sow ADFI, but did not affect piglet survivability or subsequent performance of sows.
Oral histone deacetylase inhibitor HBI-8000 (tucidinostat) in Japanese patients with relapsed or refractory non-Hodgkin’s lymphoma: phase I safety and efficacy
Authors: Yoshimitsu Makoto , Ando Kiyoshi , Ishida Takashi , Yoshida Shinichiro , Choi Ilseung , Hidaka Michihiro , Takamatsu Yasushi , Gillings Mireille , Lee Gloria T , Onogi Hiroshi , Tobinai Kensei 
Published: May 2022

Abstract

Objective
HBI-8000 (tucidinostat) is a novel, oral histone deacetylase inhibitor that selectivity inhibits Class I (histone deacetylase 1, 2, 3) and Class II (histone deacetylase 10) with direct anti-tumor activity through various mechanisms of action, including epigenetic reprogramming and immunomodulation. It has been approved in China for the treatment of relapsed or refractory peripheral T-cell lymphoma.

Methods
This multicenter, prospective phase I dose-escalation trial evaluating the safety of twice weekly HBI-8000 was conducted in Japan. Eligible patients had non-Hodgkin’s lymphoma and no available standard therapy. The primary endpoint was maximum tolerated dose; secondary endpoints included anti-tumor activity, safety and pharmacokinetics.

Results
Fourteen patients were enrolled in the study. Twelve patients were assessed for dose-limiting toxicity: six patients in the 30 mg BIW cohort had no dose-limiting toxicitys; two of six patients in the 40 mg BIW cohort had asymptomatic dose-limiting toxicitys. Treatment was well tolerated; adverse events were predominantly mild to moderate hematologic toxicities and were managed with dose modification and supportive care. Thirteen patients were included in the efficacy analysis. Objective response was seen in five of seven patients in the 40 mg BIW cohort; three partial responders had adult T-cell leukemia-lymphoma. In the 30 mg BIW cohort, three of six patients had stable disease after the first cycle.

Conclusions
Treatment with HBI-8000 30 and 40 mg BIW were well-tolerated and safe, with hematological toxicities as expected from other studies of histone deacetylase inhibitor. The maximum tolerated dose and recommended dosage for phase II studies of HBI-8000 is 40 mg BIW. Preliminary efficacy results are encouraging.
Correlates and Patterns of COVID-19 Vaccination Intentions among Parents of Children with Type 1 Diabetes
Authors: Wang Christine H , Jones Jasmine , Hilliard Marisa E , Tully Carrie , Monaghan Maureen , Marks Brynn E , Hildebrandt Tom , Streisand Randi 
Published: May 2022

Abstract

Objective
To examine psychosocial, sociodemographic, medical, and coronavirus disease 2019 (COVID-19) experiences as correlates of COVID-19 vaccination intentions among parents of children with type 1 diabetes (T1D).

Methods
121 parents of children with T1D (Mchild age = 7.78 ± 1.70; MA1c = 8.3% ± 1.5%) in the mid-Atlantic and Southwest regions completed self-report measures in February to March 2021.

Results
Parents’ general vaccination behaviors and attitudes were associated with COVID-19 vaccination intentions. Child insurance type and social distancing adherence were associated with vaccination intention in the Southwest site. Higher A1c was associated with lower intention. Vaccine safety was the top reported concern.

Conclusions
COVID-19 vaccination intentions are important to address in parents of youth with health conditions.
Crop breeding for a changing climate in the Pannonian region: towards integration of modern phenotyping tools
Authors: Kondić-Špika Ankica , Mikić Sanja , Mirosavljević Milan , Trkulja Dragana , Marjanović Jeromela Ana , Rajković Dragana , Radanović Aleksandra , Cvejić Sandra , Glogovac Svetlana , Dodig Dejan , Božinović Sofija , Šatović Zlatko , Lazarević Boris , Šimić Domagoj , Novoselović Dario , Vass Imre , Pauk János , Miladinović Dragana 
Published: May 2022

AbstractThe Pannonian Plain, as the most productive region of Southeast Europe, has a long tradition of agronomic production as well as agronomic research and plant breeding. Many research institutions from the agri-food sector of this region have a significant impact on agriculture. Their well-developed and fruitful breeding programmes resulted in productive crop varieties highly adapted to the specific regional environmental conditions. Rapid climatic changes that occurred during the last decades led to even more investigations of complex interactions between plants and their environments and the creation of climate-smart and resilient crops. Plant phenotyping is an essential part of botanical, biological, agronomic, physiological, biochemical, genetic, and other omics approaches. Phenotyping tools and applied methods differ among these disciplines, but all of them are used to evaluate and measure complex traits related to growth, yield, quality, and adaptation to different environmental stresses (biotic and abiotic). During almost a century-long period of plant breeding in the Pannonian region, plant phenotyping methods have changed, from simple measurements in the field to modern plant phenotyping and high-throughput non-invasive and digital technologies. In this review, we present a short historical background and the most recent developments in the field of plant phenotyping, as well as the results accomplished so far in Croatia, Hungary, and Serbia. Current status and perspectives for further simultaneous regional development and modernization of plant phenotyping are also discussed.
Functional characterization and vacuolar localization of fructan exohydrolase derived from onion (Allium cepa)
Authors: Oku Satoshi , Ueno Keiji , Sawazaki Yukiko , Maeda Tomoo , Jitsuyama Yutaka , Suzuki Takashi , Onodera Shuichi , Fujino Kaien , Shimura Hanako 
Published: May 2022

Abstract
Fructans such as inulin and levan accumulate in certain taxonomic groups of plants and are a reserve carbohydrate alternative to starch. Onion (Allium cepa L.) is a typical plant species that accumulates fructans, and it synthesizes inulin-type and inulin neoseries-type fructans in the bulb. Although genes for fructan biosynthesis in onion have been identified so far, no genes for fructan degradation had been found. In this study, phylogenetic analysis predicted that we isolated a putative vacuolar invertase gene (AcpVI1), but our functional analyses demonstrated that it encoded a fructan 1-exohydrolase (1-FEH) instead. Assessments of recombinant proteins and purified native protein showed that the protein had 1-FEH activity, hydrolyzing the β-(2,1)-fructosyl linkage in inulin-type fructans. Interestingly, AcpVI1 had an amino acid sequence close to those of vacuolar invertases and fructosyltransferases, unlike all other FEHs previously found in plants. We showed that AcpVI1 was localized in the vacuole, as are onion fructosyltransferases Ac1-SST and Ac6G-FFT. These results indicate that fructan-synthesizing and -degrading enzymes are both localized in the vacuole. In contrast to previously reported FEHs, our data suggest that onion 1-FEH evolved from a vacuolar invertase and not from a cell wall invertase. This demonstrates that classic phylogenetic analysis on its own is insufficient to discriminate between invertases and FEHs, highlighting the importance of functional markers in the nearby active site residues.
The DIVING3D Survey – Deep IFS view of nuclei of galaxies – II. First results: nuclear emission-line properties of the mini-DIVING3D sample
Authors: Menezes R B , Steiner J E , Ricci T V , da Silva Patrícia 
Published: May 2022

ABSTRACT
This work presents the first results of the Deep IFS View of Nuclei of Galaxies (DIVING3D) survey. We analysed the nuclear emission-line spectra of a sub-sample we call mini-DIVING3D, which includes all Southern galaxies with B &lt; 11.2 and |b| &gt; 15°. We verified that $23{{\ \rm per\ cent}} \pm 4{{\ \rm per\ cent}}$ of the galaxies show nuclear emission-line properties characteristic of Low Ionization Nuclear Emission-Line Regions (LINERs). Diagnostic diagram analysis reveals an apparent dichotomy, not detected in previous studies, between objects classified as H ii regions and as LINERs or Seyferts, with very few galaxies classified as transition objects. A possible explanation for this result is that at least part of the transition objects are composite systems, with a central LINER contaminated by the emission from circumnuclear H ii regions. The higher spatial resolution of the DIVING3D survey, in comparison with previous studies, allowed us to isolate the nuclear emission from circumnuclear contaminations, reducing the number of transition objects. We also propose an alternative scenario, in which the emission-line spectra of some transition objects are the result of shock heating by central outflows, together with photoionization by young stars. Clear evidence of active galactic nuclei, in the optical and X-ray spectral bands, were detected in 69 per cent of the LINERs in the mini-DIVING3D sample. Considering the entire mini-DIVING3D sample, evidence of AGNs were detected in 65 per cent of the objects.
Lensing cosmic drift
Authors: Covone Giovanni , Sereno Mauro 
Published: May 2022

ABSTRACT
As the Universe expands, the redshift of distant sources changes with time. Here, we discuss gravitational lensing phenomena that are consequence of the redshift drift between lensed source, gravitational lens, and observer. When the source is located very close to the drifting caustics, a pair of images could occur (or disappear) because of the cosmological expansion. Furthermore, lensing systems act as signal converters of the redshift drift. The angular position, magnification, distortion, and time delay of already existing multiple images change. We estimate the expected frequency of these phenomena and the prospects to observe them in the era of deep and large surveys. The drift detection in image separation could be within reach of next-generation surveys with μarcsec angular resolution.
A subgrid turbulent mean field dynamo model for cosmological galaxy formation simulations
Authors: Liu Yuankang , Kretschmer Michael , Teyssier Romain 
Published: May 2022

Abstract
Magnetic fields have been included in cosmological simulations of galaxy formation only recently. In this paper, we develop a new subgrid model for the turbulent dynamo that takes place in the supersonic interstellar medium in star-forming galaxies. It is based on a mean-field approach that computes the turbulent kinetic energy at unresolved scales and modifies the induction equation to account for the corresponding α dynamo. Our subgrid model depends on one free parameter, the quenching parameter, that controls the saturation of the subgrid dynamo. Thanks to this mean-field approach, we can now model the fast amplification of the magnetic field inside turbulent star-forming galaxies without using prohibitively expensive high-resolution simulations. We show that the evolution of the magnetic field in our zoom-in Milky Way-like galaxy is consistent with a simple picture, in which the field is in equipartition with the turbulent kinetic energy inside the star-forming disc, with a field strength around 10 μG at low redshift, while at the same time strong galactic outflows fill the halo with a slightly weaker magnetic field, whose strength (10 nG) is consistent will the ideal MHD dilution factor. Our results are in good agreement with recent theoretical and numerical predictions. We also compare our simulation with Faraday depth observations at both low and high redshift, seeing overall good agreement with some caveats. Our model naturally predicts stronger magnetic fields at high redshift (around 100 μG in the galaxy and 1 μG in the halo), but also stronger depolarisation effects due to stronger turbulence at early time.
Detecting PAHs in high-z galaxies in proxy: modelling physical conditions in an extremely strong damped Lyman α absorber towards QSO SDSS J1143+1420 at z = 2.323
Authors: Shaw Gargi , Ranjan A 
Published: May 2022

ABSTRACT
We explore indirect methods to detect polycyclic aromatic hydrocarbons (PAHs) in gas-rich, absorption-selected galaxies at high redshift. We look at the optical X-Shooter observations of an intervening, extremely strong damped Lyman α absorber (or ESDLA, with log [N(H i) ≳ 21.7)] towards QSO SDSS J1143+1420 at redshift, zESDLA = 2.323. Literature studies have shown that this ESDLA contains signatures of dust and diffuse molecular hydrogen and it was specifically chosen for our study due to its close spatial proximity (impact parameter, $\rm \rho = 0.6\, \pm \, 0.3$kpc) with its associated galaxy. There is no direct detection of PAHs emission in the limited observations of infrared spectra along this sightline. Hence, we use cloudy numerical simulation modelling to indirectly probe the presence of PAHs in the ESDLA. We note that PAHs need to be included in the models to reproduce the observed column densities of warm H2 and C i. Thus, we infer the presence of PAHs indirectly in our ESDLA, with an abundance of PAH/H = 10−7.046. We also measure a low 2175 Å  bump strength (E$\rm _{bump}\, \sim$0.03–0.19 mag) relative to star-forming galaxies by modelling extinction of quasar QSO spectra by dust at the absorber rest frame. This is consistent with the low PAH abundance obtained indirectly using cloudy modelling. Our study highlights the usage of cloudy modelling to indirectly detect PAH in high-redshift gas-rich absorption-selected galaxies.
The VVV open cluster project II. Near-infrared sequences of 37 open clusters on eight-dimensional parameter space
Authors: Ramírez K Peña , Smith L C , Alegría S Ramírez , Chené A-N , González-Fernández C , Lucas P W , Minniti D 
Published: May 2022

Abstract
Open clusters are key coeval structures that help us understand star formation stellar evolution and trace the physical properties of our Galaxy. In the past years, the isolation of open clusters from the field has been heavily alleviated by the access to accurate large-scale stellar parallaxes and proper motions along a determined line of sight. Still, there are limitations regarding their completeness since large-scale studies rely on optical wavelengths. Here we extend the open clusters sequences towards fainter magnitudes complementing the Gaia photometric and astrometric information with near-infrared data from the VVV survey. We performed a homogeneous analysis on 37 open clusters implementing two coarse-to-fine characterization methods: extreme deconvolution Gaussian mixture models coupled with an unsupervised machine learning method on 8-dimensional parameter space. The process allowed us to separate the clusters from the field at near-infrared wavelengths. We report an increase of ∼47 per cent new member candidates on average in our sample (considering only sources with high membership probability p≧0.9). This study is the second in a series intended to reveal open cluster near-infrared sequences homogeneously.
Observational bias and young massive cluster characterization – I. 2D perspective effects
Authors: Buckner Anne S M , Liow Kong You , Dobbs Clare L , Naylor Tim , Rieder Steven 
Published: May 2022

ABSTRACT
Understanding the formation and evolution of high-mass star clusters requires comparisons between theoretical and observational data to be made. Unfortunately, while the full phase space of simulated regions is available, often only partial 2D spatial and kinematic data is available for observed regions. This raises the question as to whether cluster parameters determined from 2D data alone are reliable and representative of clusters real parameters and the impact of line-of-sight orientation. In this paper, we derive parameters for a simulated cluster formed from a cloud–cloud collision with the full 6D phase space, and compare them with those derived from three different 2D line-of-sight orientations for the cluster. We show the same qualitative conclusions can be reached when viewing clusters in 2D versus 3D, but that drawing quantitative conclusions when viewing in 2D is likely to be inaccurate. The greatest divergence occurs in the perceived kinematics of the cluster, which in some orientations appears to be expanding when the cluster is actually contracting. Increases in the cluster density compounds pre-existing perspective issues, reducing the relative accuracy and consistency of properties derived from different orientations. This is particularly problematic for determination of the number, and membership, of subclusters present in the cluster. We find the fraction of subclusters correctly identified in 2D decreases as the cluster evolves, reaching less than $3.4{{\ \rm percent}}$ at the evolutionary end point for our cluster.
Neutron-capture elements record the ordered chemical evolution of the disc over time
Authors: Horta Danny , Ness Melissa K , Rybizki Jan , Schiavon Ricardo P , Buder Sven 
Published: May 2022

ABSTRACT
An ensemble of chemical abundances probing different nucleosynthetic channels can be leveraged to build a comprehensive understanding of the chemical and structural evolution of the Galaxy. Using GALAH DR3 data, we seek to trace the enrichment by the supernovae Ia, supernovae II, asymptotic giant branch stars, and neutron-star mergers and/or collapsars nucleosynthetic sources by studying the [Fe/H], [α/Fe], [Ba/Fe], and [Eu/Fe] chemical compositions of ∼50 000 red giant stars, respectively. Employing small [Fe/H]–[α/Fe] cells, which serve as an effective reference-frame of supernovae contributions, we characterize the abundance-age profiles for [Ba/Fe] and [Eu/Fe]. Our results disclose that these age–abundance relations vary across the [Fe/H]–[α/Fe] plane. Within cells, we find negative age–[Ba/Fe] relations and flat age–[Eu/Fe] relations. Across cells, we see the slope of the age–[Ba/Fe] relations evolve smoothly and the [Eu/Fe] relations vary in amplitude. We subsequently model our empirical findings in a theoretical setting using the flexible Chempy Galactic chemical evolution (GCE) code, using the mean [Fe/H], [Mg/Fe], [Ba/Fe], and age values for stellar populations binned in [Fe/H], [Mg/Fe], and age space. We find that within a one-zone framework, an ensemble of GCE model parameters vary to explain the data. Using present day orbits from Gaia EDR3 measurements we infer that the GCE model parameters, which set the observed chemical abundance distributions, vary systematically across mean orbital radii. Under our modelling assumptions, the observed chemical abundances are consistent with a small gradient in the high-mass end of the initial mass function (IMF) across the disc, where the IMF is more top heavy towards the inner disc and more bottom heavy in the outer disc.