bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization of AML‐MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC‐defining criteria, TP53 allelic state, or TP53 variant allele frequency
Authors: Zhao Davidson , Eladl Entsar , Zarif Mojgan , Capo‐Chichi José‐Mario , Schuh Andre , Atenafu Eshetu , Minden Mark , Chang Hong 
Published: November 2022

AbstractBackgroundAcute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) generally confers poor prognosis, however, patient outcomes are heterogeneous. The impact of TP53 allelic state and variant allele frequency (VAF) in AML‐MRC remains poorly defined.MethodsWe retrospectively evaluated 266 AML‐MRC patients who had NGS testing at our institution from 2014 to 2020 and analyzed their clinical outcomes based on clinicopathological features.ResultsTP53 mutations were associated with cytogenetic abnormalities in 5q, 7q, 17p, and complex karyotype. Prognostic evaluation of TP53MUT AML‐MRC revealed no difference in outcome between TP53 double/multi‐hit state and single‐hit state. Patients with high TP53MUT variant allele frequency (VAF) had inferior outcomes compared to patients with low TP53MUT VAF. When compared to TP53WT patients, TP53MUT patients had inferior outcomes regardless of MRC‐defining criteria, TP53 allelic state, or VAF. TP53 mutations and elevated serum LDH were independent predictors for inferior OS and EFS, while PHF6 mutations and transplantation were independent predictors for favorable OS and EFS. NRAS mutation was an independent predictor for favorable EFS.ConclusionsOur study suggests that TP53MUT AML‐MRC defines a very‐high‐risk subentity of AML in which novel therapies should be explored.
Giant aneurysm of the circumflex artery
Authors: Karangelis Dimos , Alexiou Christos , Christodoulou Konstantinos C. , Gerontitis Zisis , Mikroulis Dimitrios 
Published: November 2022

AbstractIn this paper, we describe a rare case of a giant aneurysm of the circumflex artery that we managed. A 59‐year‐old female patient presented in cardiogenic shock after partial aneurysm rupture. Giant aneurysms of the circumflex artery are extremely rare entities. The optimal surgical management dictates meticulous preoperative planning and the operation should be carried out on an elective basis.
Extreme hyperferritinemia without associated HLH in a patient with T‐cell lymphoma
Authors: Lau Grace , Dougherty Sean C. , Friedman Lisa , Wispelwey Brian 
Published: November 2022

AbstractExtreme hyperferritinemia has historically been associated with a short list of rare diagnoses, including hemophagocytic lymphohistiocytosis (HLH). However, hyperferritinemia is not specific for HLH in the adult population. Among other more common causes, T‐cell lymphoma and other malignancies warrant evaluation prior to considering more rare diagnoses.
Effect of particle size of calcite on the stacking order of kaolinite during mechanical grinding
Authors: Machida Shingo , Katsumata Kenichi , Yasumori Atsuo 
Published: November 2022

AbstractThe effect of calcium carbonate (CaCO3) particles on the stacking order of kaolinite, a layered clay mineral, during the mechanical grinding process was demonstrated by grinding of expanded kaolinite without impurities (Ex‐Kaol), a methoxy‐modified kaolinite, in the presence and absence of calcite with different particle sizes. The X‐ray diffraction patterns of the ground raw materials revealed that the relative intensity of the reflection corresponding to stacking direction of kaolinite decreased in the absence of calcite particles. The presence of calcite particles suppressed the disruption of the stacking order of kaolinite due to the breaking of calcite particles. In addition, this suppression was weakened using calcite particles of smaller size. Meanwhile, the raw ground material containing smaller calcite particles converted into the targeted product faster than the raw ground material containing larger calcite particles. These results indicated that the particle sizes of raw materials are important for solid‐state reactions including kaolinite.
Computational fluid dynamic study of polycaprolactone nanoparticles precipitation in a co‐flow capillary micro‐tube
Authors: Ghasemzade Bariki Saeed , Salman Movahedirad , Ghojavand Majid 
Published: November 2022

AbstractPolycaprolactone nanoparticles (NPs) were produced in the co‐flow glass capillary device with tip dimension. NPs size was 990 nm for continuous phase velocity, and and 426 nm for . The droplet formation process in the co‐flow microchannel was also simulated using computational fluid dynamic (CFD). Employing a digital image analysis technique, a cut‐off value of 0.81 for the dispersed phase volume fraction was proposed for the determination of droplet size. A scenario was expressed for NP formation from micro‐droplets. Moreover, after conducting 27 CFD simulations, a dimensionless exponential form correlation was proposed for droplet size estimation. In this generalized map, there were three distinct regions based on the relative capillary numbers of continuous to dispersed phases. It was revealed that at a constant dispersed phase velocity, by increasing the continuous phase velocity, more small NPs are formed. The results show that the ratio of micro‐droplets to NPs size was between 735 and 755.
Topographical organization and morphology of substance P (SP)‐immunoreactive axons in the whole stomach of mice
Authors: Ma Jichao , Mistareehi Anas , Madas Jazune , Kwiat Andrew M. , Bendowski Kohlton , Nguyen Duyen , Chen Jin , Li De‐Pei , B. Furness John , L. Powley Terry , Cheng Zixi (Jack) 
Published: November 2022

AbstractNociceptive afferents innervate the stomach and send signals centrally to the brain and locally to stomach tissues. Nociceptive afferents can be detected with a variety of different markers. In particular, substance P (SP) is a neuropeptide and is one of the most commonly used markers for nociceptive nerves in the somatic and visceral organs. However, the topographical distribution and morphological structure of SP‐immunoreactive (SP‐IR) axons and terminals in the whole stomach have not yet been fully determined. In this study, we labeled SP‐IR axons and terminals in flat mounts of the ventral and dorsal halves of the stomach of mice. Flat‐mount stomachs, including the longitudinal and circular muscular layers and the myenteric ganglionic plexus, were processed with SP primary antibody followed by fluorescent secondary antibody and then scanned using confocal microscopy. We found that (1) SP‐IR axons and terminals formed an extensive network of fibers in the muscular layers and within the ganglia of the myenteric plexus of the whole stomach. (2) Many axons that ran in parallel with the long axes of the longitudinal and circular muscles were also immunoreactive for the vesicular acetylcholine transporter (VAChT). (3) SP‐IR axons formed very dense terminal varicosities encircling individual neurons in the myenteric plexus; many of these were VAChT immunoreactive. (4) The regional density of SP‐IR axons and terminals in the muscle and myenteric plexus varied in the following order from high to low: antrum‐pylorus, corpus, fundus, and cardia. (5) In only the longitudinal and circular muscles, the regional density of SP‐IR axon innervation from high to low were: antrum‐pylorus, corpus, cardia, and fundus. (6) The innervation patterns of SP‐IR axons and terminals in the ventral and dorsal stomach were comparable. Collectively, our data provide for the first time a map of the distribution and morphology of SP‐IR axons and terminals in the whole stomach with single‐cell/axon/synapse resolution. This work will establish an anatomical foundation for functional mapping of the SP‐IR axon innervation of the stomach and its pathological remodeling in gastrointestinal diseases.
Comparability of Foslevodopa/Foscarbidopa Pharmacokinetics in Healthy Asian and White Participants
Authors: Rosebraugh Matthew , Neenan Melina , Facheris Maurizio 
Published: November 2022

AbstractThis phase 1 study assessed the safety, tolerability, and pharmacokinetics of a single 24‐hour continuous subcutaneous dose of foslevodopa/foscarbidopa in healthy adult Japanese (N = 24), Han Chinese (N = 8), and White (N = 24) participants. Three doses of foslevodopa/foscarbidopa were evaluated in healthy participants for this study: 480/24, 960/48, and 1440/72 mg/day. Serial blood samples for measurement of levodopa, carbidopa, foslevodopa, foscarbidopa, and 3‐O‐methyldopa concentrations were collected for 48 hours after foslevodopa/foscarbidopa administration. Safety and tolerability were assessed throughout the study. Point estimates for ratios of central values indicated that the exposure difference between Japanese and White participants was <10%. The maximum concentration and area under the plasma concentration–time curve for both LD and CD following foslevodopa/foscarbidopa continuous subcutaneous infusion were comparable between Han Chinese and White participants. Point estimates for ratios of central values indicated that the exposure difference between Han Chinese and White participants was <14%. The regimens tested were generally well tolerated, and no new safety issues were identified in this study. There were no clinically meaningful differences in LD and CD exposures or pharmacokinetics following administration of foslevodopa/foscarbidopa among White, Japanese, and Han Chinese participants.
Capturing the Polarization Response of Solvated Proteins under Constant Electric Fields in Molecular Dynamics Simulations
Authors: Chakraborty Anustup , Venkatramani Ravindra 
Published: November 2022

AbstractWe capture and compare the polarization response of a solvated globular protein ubiquitin to static electric (E‐fields) using atomistic molecular dynamics simulations. We collectively follow E‐field induced changes, electrical and structural, occurring across multiple trajectories using the magnitude of the protein dipole vector (Pp). E‐fields antiparallel to Pp induce faster structural changes and more facile protein unfolding relative to parallel fields of the same strength. While weak E‐fields (0.1–0.5 V/nm) do not unfold ubiquitin and produce a reversible polarization, strong E‐fields (1–2 V/nm) unfold the protein through a pathway wherein the helix:β‐strand interactions rupture before those for the β1‐β5 clamp. Independent of E‐field direction, high E‐field induced structural changes are also reversible if the field is switched off before Pp exceeds 2 times its equilibrium value. We critically examine the dependence of water properties, protein rotational diffusion and E‐field induced protein unfolding pathways on the thermostat/barostat parameters used in our simulations.
Effects of Microhydration on the Mechanisms of Hydrolysis and Cl− Substitution in Reactions of N2O5 and Seawater
Authors: McCaslin Laura M. , Götz Andreas W. , Johnson Mark A. , Gerber R. Benny 
Published: November 2022

AbstractThe reaction of N2O5 at atmospheric interfaces has recently received considerable attention due to its importance in atmospheric chemistry. N2O5 reacts preferentially with Cl− to form ClNO2/NO3− (Cl− substitution), but can also react with H2O to form 2HNO3 (hydrolysis). In this paper, we explore these competing reactions in a theoretical study of the clusters N2O5/Cl−/nH2O (n=2–5), resulting in the identification of three reaction motifs. First, we uncovered an SN2‐type Cl− substitution reaction of N2O5 that occurs very quickly due to low barriers to reaction. Second, we found a low‐lying pathway to hydrolysis via a ClNO2 intermediate (two‐step hydrolysis). Finally, we found a direct hydrolysis pathway where H2O attacks N2O5 (one‐step hydrolysis). We find that Cl− substitution is the fastest reaction in every cluster. Between one‐step and two‐step hydrolysis, we find that one‐step hydrolysis barriers are lower, making two‐step hydrolysis (via ClNO2 intermediate) likely only when concentrations of Cl− are high.
Analytical non‐Fourier solution of linear time‐invariant circuits with periodic inputs
Authors: Safaai‐Jazi Ahmad 
Published: November 2022

SummaryA systematic approach for solving linear time‐invariant electric circuits with periodic input signals is presented. The method involves the following steps: (1) The governing differential equation for the desired output is solved for each time segment of the input signal in one period, leaving the constant coefficients of the homogeneous parts of the solution as unknowns. For an nth‐order circuit with a source consisting of q segments in one period, there are
such unknown coefficients. (2) Using the solution obtained in step 1, the voltage of each capacitor and the current of each inductor are determined. (3) Transition conditions for the voltages and currents found in step 2 at the transition points of successive segments and also periodicity conditions for the beginning and end points of the period are applied. (4) Implementation of step 3 results in a system of
equations in terms of the
unknown coefficients described in step 1. Solving this system of equations, the circuit response in one period becomes readily available.
Cobalt Complexes as Efficient Cooperative Catalysts for Transfer Hydrogenation
Authors: Yadav Samanta , Prabha Divya , Ahluwalia Deepali , Bag Arijit , Gupta Rajeev 
Published: November 2022

AbstractCobalt complexes of amide‐based ligands appended with protonated heterocyclic rings are utilized as the earth‐abundant catalysts for the transfer hydrogenation of assorted carbonyl compounds using isopropanol as the hydrogen source. The most successful complex illustrated remarkable catalytic performance towards a wide range of aldehydes and ketones, quantitatively yielding primary and secondary alcohols as the products, respectively. The catalysis scope also included a few biologically relevant substrates such as furfural, vanillin, ortho‐vanillin, coumarin and chalcone. The substrate binding, Hammett, kinetic and DFT studies provided the mechanistic insights.
A hierarchical assessment of resilience engineering indicators in petrochemical industries using AHP and TOPSIS
Authors: Shirali Gh. A. , Rashnoudi P. , Salehi V. , Ghanbari S. 
Published: November 2022

AbstractResilience engineering (RE) is a proactive approach that enables complex systems to deal with adverse events and improve safety management by enhancing structural and organizational capabilities. A methodological examination of RE‐related studies showed that they had only focused on some major indicators so that subindicators have been mostly neglected. This study aims to present a hierarchical analysis to identify the importance degree of indicators and subindicators of RE using analytic hierarchy process (AHP) in a petrochemical plant. To accomplish this, a pairwise comparison matrix of the indicators and subindicators was used to collect the data required for AHP approach. To demonstrate the applicability of the AHP results, this study ranks the units of the petrochemical plant using the technique for the order of preference by similarity to an ideal solution (TOPSIS) approach based on the importance degree of RE indicators. A questionnaire was used to gather data related to RE indicators so we could use the TOPSIS method. The results of the AHP showed that management commitment, buffering capacity, and reporting culture were the most influential RE indicators. In addition, anticipation had the lowest impact on RE. The most important subindicators of the RE indicators were also identified using a hierarchical analysis through AHP. The results of TOPSIS provided a best–worst analysis of the units of the petrochemical plant. The findings of this study could help safety managers formulate better‐targeted safety policies by investing in influential indicators and subindicators of RE.
Estimation of the capacity for self-purification of transformed rivers of Khanty-Mansi Autonomous Okrug-Yugra (Russia)
Authors: Shornikova E. A. , Arslanova M. M. 
Published: November 2022

Abstract
This article presents an estimation of the self-purification capacity of rivers flowing through an area of the Ob River basin at Khanty-Mansi Autonomous Okrug-Yugra, which has been significantly transformed by the oil and gas industry. The research was done on the rivers of the Ob River basin in oil fields in 2003–2006 and 2018–2019. The coefficient of mineralization of organic matter has been used as a criterion of the rivers’ water self-purification levels. The mineralization coefficient was based on the ratio of numbers of bacteria consuming ammonium nitrogen and polymer substances as well as saprophytic heterotrophic bacteria. According to the results obtained, most rivers draining the oil field area (75% in 2003–2006 and 79% in 2018–2019) were characterized by a low potential for self-purification. The highest level of self-purification criteria was obtained for two rivers: the Ai-Pim River in the Surgut region and the Ovyn'yegan River in the Oktyabrsky region. The high level of self-purification detected with the coeficient of mineralization ensures the maintenance of a certain trophical level and environmental balance of the aquatic ecosystem. Complicated technological processes applied in the oil and gas industry, as well as outdated equipment and poor environmental management, often lead to pipeline accidents and other infrastructure failures. Hazardous pollutants flow into rivers from the watershed area and further into the Gulf of Ob of the Kara Sea. Continuous monitoring of water quality and water resource management based on the results obtained will constitute serious measures to prevent deterioration of aquatic ecosystems. It is necessary to include microbiological parameters in monitoring programs, as this helps to identify the processes of transformation of chemicals found in the river. The use of self-purification assessment methodology for rivers in oil field areas yields effective results in the decision-making process in the sphere of water resource management, significantly reducing ecological risks in the Ob River basin and, as a consequence, in the Arctic region. Integr Environ Assess Manag 2023;19:988–993. © 2022 SETAC
Ethnic‐specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population
Authors: Qin Zixin , Li Jiaheng , Tam Benjamin , Sinha Siddharth , Zhao Bojin , Bhaskaran Shanmuga Priya , Huang Teng , Wu Xiaobing , Chian Jia Sheng , Guo Maoni , Kou Si Hoi , Lei Huijun , Zhang Li , Wang Xiaoyu , Lagniton Philip Naderev P. , Xiao Fengxia , Jiang Xinyang , Wang San Ming 
Published: November 2022

AbstractPathogenic variation in BRCA1 and BRCA2 (BRCA) causes high risk of breast and ovarian cancer, and BRCA variation data are important markers for BRCA‐related clinical cancer applications. However, comprehensive BRCA variation data are lacking from the Asian population despite its large population size, heterogenous genetic background and diversified living environment across the Asia continent. We performed a systematic study on BRCA variation in Asian population including extensive data mining, standardization, annotation and characterization. We identified 7587 BRCA variants from 685 592 Asian individuals in 40 Asia countries and regions, including 1762 clinically actionable pathogenic variants and 4915 functionally unknown variants (https://genemutation.fhs.um.edu.mo/Asian-BRCA/). We observed the highly ethnic‐specific nature of Asian BRCA variants between Asian and non‐Asian populations and within Asian populations, highlighting that the current European descendant population‐based BRCA data is inadequate to reflect BRCA variation in the Asian population. We also provided archeological evidence for the evolutionary origin and arising time of Asian BRCA variation. We further provided structural‐based evidence for the deleterious variants enriched within the functionally unknown Asian BRCA variants. The data from our study provide a current view of BRCA variation in the Asian population and a rich resource to guide clinical applications of BRCA‐related cancer for the Asian population.
Effectiveness of the “pain‐free dental injection” (PaFein) teaching model in reducing children's pain: A randomized, controlled study
Authors: Kuscu Ozgur Onder , Ozcelik Selcuk Mert , Kucuktepe Coskun , Bekiroglu Nural , Akyuz Serap 
Published: November 2022

AbstractPurposeThis study explores the effectiveness of a comprehensive structured teaching model – the “PaFein” – for instructing postgraduate pediatric dental residents in the provision of pain‐free local anesthesia to children.MethodsTen postgraduate pediatric dental residents and 172 children between the ages 5 and 13 participated in the study following ethical approval. The previously measured baselines guided the randomization of study and control groups. The study group (five residents) attended the PaFein course (9 hours). Based on power calculations, residents performed dental injections (8 mandibular block, 8 palatal/lingual and 14 buccal infiltrations) in randomly assigned child patients. Demographic data of residents/children, parental and self‐report anxiety scores and Visual Analogue Scale (VAS) pain scores were noted to examine children's anxiety and pain during dental injections.ResultsChildren's mean anxiety score did not differ significantly between groups; however, VAS pain reports during dental injections (a, b, c, d) were found lower in the PaFein study group than the control group (p < 0.05). VAS pain reports for (a) buccal injections were 1.08 and 1.9 (p = 0.02); (b) inferior alveolar nerve blocks were 1.58 and 3.37 (p = 0.0002); (c) palatal/lingual injections were 1.34 and 3.02 (p < 0.0001); (d) total means were 1.28 and 2.59, respectively (p = 0.0001). VAS pain reports of anxious and non‐anxious children in the PaFein study group (1.63 and 1.17) were also lower than the control group (3.33 and 2.39) (p < 0.0001 and p = 0.005).ConclusionThe “PaFein” teaching model was found to be effective in training dental residents to reduce dental injection pain in children, including the anxious ones.
A rare cause of jejunal perforation: Monomorphic epitheliotropic intestinal T‐cell lymphoma
Authors: Yanagi Masahiro , Komura Takuya , Kagaya Takashi 
Published: November 2022

AbstractMonomorphic epitheliotropic intestinal T‐cell lymphoma (MEITL) is a very rare intestinal T‐cell lymphoma which is observed most frequently in the jejunum. MEITL is prone to cause intestinal perforation and the prognosis is very poor when it occurs. Here we report a fatal case of MEITL causing jejunal perforation at the time of diagnosis in a 79‐year‐old man. The patient underwent emergency surgery for jejunal perforation caused by MEITL but died 3 months after the initial visit due to prolonged peritonitis. It is desirable to establish a method to predict cases with intestinal perforation, and systematize the treatment strategies to avoid perforation.