bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performances of whole-brain dynamic and static functional connectivity fingerprinting in machine learning-based classification of major depressive disorder
Authors: Niu Heng , Li Weirong , Wang Guiquan , Hu Qiong , Hao Rui , Li Tianliang , Zhang Fan , Cheng Tao 
Published: July 2022

BackgroundAlterations in static and dynamic functional connectivity during resting state have been widely reported in major depressive disorder (MDD). The objective of this study was to compare the performances of whole-brain dynamic and static functional connectivity combined with machine learning approach in differentiating MDD patients from healthy controls at the individual subject level. Given the dynamic nature of brain activity, we hypothesized that dynamic connectivity would outperform static connectivity in the classification.MethodsSeventy-one MDD patients and seventy-one well-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. Whole-brain dynamic and static functional connectivity patterns were calculated and utilized as classification features. Linear kernel support vector machine was employed to design the classifier and a leave-one-out cross-validation strategy was used to assess classifier performance.ResultsExperimental results of dynamic functional connectivity-based classification showed that MDD patients could be discriminated from healthy controls with an excellent accuracy of 100% irrespective of whether or not global signal regression (GSR) was performed (permutation test with P &lt; 0.0002). Brain regions with the most discriminating dynamic connectivity were mainly and reliably located within the default mode network, cerebellum, and subcortical network. In contrast, the static functional connectivity-based classifiers exhibited unstable classification performances, i.e., a low accuracy of 38.0% without GSR (P = 0.9926) while a high accuracy of 96.5% with GSR (P &lt; 0.0002); moreover, there was a considerable variability in the distribution of brain regions with static connectivity most informative for classification.ConclusionThese findings suggest the superiority of dynamic functional connectivity in machine learning-based classification of depression, which may be helpful for a better understanding of the neural basis of MDD as well as for the development of effective computer-aided diagnosis tools in clinical settings.
Mental Health Research During the COVID-19 Pandemic: Focuses and Trends
Authors: Liang Yaodong , Sun Li , Tan Xin 
Published: July 2022

BackgroundThe COVID-19 pandemic has profoundly influenced the world. In wave after wave, many countries suffered from the pandemic, which caused social instability, hindered global growth, and harmed mental health. Although research has been published on various mental health issues during the pandemic, some profound effects on mental health are difficult to observe and study thoroughly in the short term. The impact of the pandemic on mental health is still at a nascent stage of research. Based on the existing literature, we used bibliometric tools to conduct an overall analysis of mental health research during the COVID-19 pandemic.MethodResearchers from universities, hospitals, communities, and medical institutions around the world used questionnaire surveys, telephone-based surveys, online surveys, cross-sectional surveys, systematic reviews and meta-analyses, and systematic umbrella reviews as their research methods. Papers from the three academic databases, Web of Science (WOS), ProQuest Academic Database (ProQuest), and China National Knowledge Infrastructure (CNKI), were included. Their previous research results were systematically collected, sorted, and translated and CiteSpace 5.1 and VOSviewers 1.6.13 were used to conduct a bibliometric analysis of them.ResultAuthors with papers in this field are generally from the USA, the People's Republic of China, the UK, South Korea, Singapore, and Australia. Huazhong University of Science and Technology, Hong Kong Polytechnic University, and Shanghai Jiao Tong University are the top three institutions in terms of the production of research papers on the subject. The University of Toronto, Columbia University, and the University of Melbourne played an important role in the research of mental health problems during the COVID-19 pandemic. The numbers of related research papers in the USA and China are significantly larger than those in the other countries, while co-occurrence centrality indexes in Germany, Italy, England, and Canada may be higher.ConclusionWe found that the most mentioned keywords in the study of mental health research during the COVID-19 pandemic can be divided into three categories: keywords that represent specific groups of people, that describe influences and symptoms, and that are related to public health policies. The most-cited issues were about medical staff, isolation, psychological symptoms, telehealth, social media, and loneliness. Protection of the youth and health workers and telemedicine research are expected to gain importance in the future.
College students' cyberloafing and the sense of meaning of life: The mediating role of state anxiety and the moderating role of psychological flexibility
Authors: Li Qing , Xia Bingnan , Zhang Huijia , Wang Wei , Wang Xiaochen 
Published: July 2022

BackgroundWith the gradual penetration of network media into various fields of people's life, the relationship between network behavior and the sense of meaning of life is bound to be closer and closer. The purpose of this study is to explore the mediating role of state anxiety between cyber loafing and the sense of meaning of life, and the moderating role of psychological flexibility in this mediating relationship.MethodologyWith 964 undergraduates recruited as subjects three-wave-time-lagged quantitative research design was conducted in China. All participants were required to complete a self-reported electronic questionnaire. Then, the mediating mechanism and moderating effect were explored with utilization of SPSS25.0.ResultsThe results showed that cyberloafing had significant negative correlation with the sense of meaning of life. Our analysis testing the mediating effect showed that state anxiety partially mediated the relationship between cyberloafing and the sense of meaning of life (indirect effect = −0.05, p &lt; 0.01,), while the mediating effect was 31.25% of the total effect. Our analysis testing the moderating effect showed that psychological flexibility significantly moderated the relationship between cyberloafing and state anxiety (interaction effect = −0.26, p &lt; 0.01). And our analysis testing the moderated mediating effect showed that psychological flexibility played a moderating role in the mediating effect of state anxiety.ConclusionBased on the findings of this study, college students' cyberloafing negatively affects their sense of meaning of life. Therefore, appropriate measures should be taken to supervise and restrict college students' Internet use and provide them with corresponding guidance; certain psychological adjustment measures should also be taken when necessary to help college students with low psychological flexibility in reducing their state anxiety and improving their sense of meaning of life.
Incision pressing, a simple and effective intervention to reduce colorectal surgical site infection: A propensity score-matched study
Authors: Jiang Yugang , Chen Hongyuan , Liu Guotao , Liu Meifeng , Kong Meng , Sheng Hongguang 
Published: July 2022

BackgroundColorectal surgery is associated with a high risk of surgical site infection (SSI). In March 2017, we developed an intervention, called “PRESS”, with the aim of reducing colorectal superficial SSI. This study assessed the effect of the new intervention in reducing the rates of superficial SSI in colorectal surgery.MethodsThis study was a retrospective review of 312 PRESS+ patients compared to 171 historical control PRESS− patients who were 18 years of age or older and underwent elective colorectal surgery with clean-contaminated wounds from January 2015 to June 2020. In the PRESS+ groups, we pressed the incision downward hard with clean gauze after the interrupted suturing of the skin. Propensity score matching with 15 variables was performed in a 1:1 ratio to reduce selection bias. Univariate analysis and multivariate analysis were performed to identify risk factors associated with SSI.ResultsThe characteristics of the PRESS+ (n = 160) and PRESS− (n = 160) groups were well balanced after propensity score matching. The PRESS+ group had a lower superficial SSI rate (1.9% vs. 6.9%, P = 0.029) and a lower overall SSI rate (2.5% vs. 10.0%, P = 0.006) than the PRESS− group. Furthermore, multivariate analysis showed that the incisional press was an effective protective factor for superficial SSI (adjusted odds ratio = 0.215, 95% confidence interval = 0.057–0.818, P = 0.024). In addition, female sex (P = 0.048) and blood transfusion (P = 0.011) were demonstrated to be independent risk factors for superficial SSI.ConclusionThe incisional press after suturing is a simple, costless, and effective intervention in reducing superficial incisional SSI.
Prediction of acute kidney injury in patients with femoral neck fracture utilizing machine learning
Authors: Liu Jun , Xu Lingxiao , Zhu Enzhao , Han Chunxia , Ai Zisheng 
Published: July 2022

BackgroundAcute kidney injury (AKI) is a common complication associated with significant morbidity and mortality in high-energy trauma patients. Given the poor efficacy of interventions after AKI development, it is important to predict AKI before its diagnosis. Therefore, this study aimed to develop models using machine learning algorithms to predict the risk of AKI in patients with femoral neck fractures.MethodsWe developed machine-learning models using the Medical Information Mart from Intensive Care (MIMIC)-IV database. AKI was predicted using 10 predictive models in three-time windows, 24, 48, and 72 h. Three optimal models were selected according to the accuracy and area under the receiver operating characteristic curve (AUROC), and the hyperparameters were adjusted using a random search algorithm. The Shapley additive explanation (SHAP) analysis was used to determine the impact and importance of each feature on the prediction. Compact models were developed using important features chosen based on their SHAP values and clinical availability. Finally, we evaluated the models using metrics such as accuracy, precision, AUROC, recall, F1 scores, and kappa values on the test set after hyperparameter tuning.ResultsA total of 1,596 patients in MIMIC-IV were included in the final cohort, and 402 (25%) patients developed AKI after surgery. The light gradient boosting machine (LightGBM) model showed the best overall performance for predicting AKI before 24, 48, and 72 h. AUROCs were 0.929, 0.862, and 0.904. The SHAP value was used to interpret the prediction models. Renal function markers and perioperative blood transfusions are the most critical features for predicting AKI. In compact models, LightGBM still performs the best. AUROCs were 0.930, 0.859, and 0.901.ConclusionsIn our analysis, we discovered that LightGBM had the best metrics among all algorithms used. Our study identified the LightGBM as a solid first-choice algorithm for early AKI prediction in patients after femoral neck fracture surgery.
Hybrid fixation with ESIN for both bone forearm fractures in adults: A case report and literature review
Authors: Bai Xiaodong , Liu Zhenyu , Chen Wentao , Wang Baojun 
Published: July 2022

ObjectiveBoth bone forearm fractures are common in children and rare in adults. The main surgical treatment is open reduction and internal fixation (ORIF) with plate, while the hybrid fixation of elastic-stable intramedullary nailing (ESIN) and the plate has been rarely reported before.Case reportWe report a case of a 29-year-old male patient with both bone forearm fractures. Temporarily closed reduction and plaster external fixation were performed in the emergency room, and the patient was admitted to the orthopedic trauma ward for surgery. The patient underwent open reduction and plate fixation of the ulna and closed reduction and ESIN fixation of the radius. The fractures healing was satisfactory and the internal fixation was removed 12 months postoperatively.ConclusionThe hybrid fixation of ESIN and plate is an effective option for both bone forearm fractures in adults.
Berbamine and thymoquinone exert protective effects against immune-mediated liver injury via NF-κB dependent pathway
Authors: Kathem Sarmed H. , Abdulsahib Waleed K. , Zalzala Munaf H. 
Published: July 2022

BackgroundImmune-mediated hepatitis is a severe impendence to human health, and no effective treatment is currently available. Therefore, new, safe, low-cost therapies are desperately required. Berbamine (BE), a natural substance obtained primarily from Berberis vulgaris L, is a traditional herbal medicine with several bioactivities, such as antimicrobial and anticancer activities. Thymoquinone (TQ), a phytochemical molecule derived from the Nigella sativa plant's black cumin seeds, has attracted interest owing to itsanti-inflammatory, antioxidant, and anticancer properties.AimThis current study's aims was to examine the protective impacts of BE and TQ in Concanavalin A (ConA)- induced acute liver injury and the action's underlying mechanism.Methodssixty mice of both sexes were used and divided into four groups (each group with six mice) as follows: Group I obtained distilled water (negative control group). Group II received distilled water with a single dose of 0.1 ml ConA (20 mg/kg) on day 4 by retro-orbital route (model group). Groups III and IV received BE (30 mg/kg/day) and TQ (25 mg/kg/day), respectively, by oral gavage for four successive days, with a single dose of ConA (20 mg/kg) on day 4, then all animals were sacrificed after 8 h and prepared for liver and blood collection.ResultsConA administration increased the ALT, AST, TNF-α, INFγ, and NF-κB significantly (p &lt; 0.001) in the model group. Both BE and TQ could reduce these parameters significantly (p &lt; 0.001) in groups III and IV, respectively, compared to the model group.ConclusionBoth BE and TQ prominently attenuated ConA immune-mediated liver injury. These findings give a remarkable insight into developing a new therapeutic agent for treating hepatitis and other autoimmune diseases.
“Boris Godunov” in the Kuban and “Sokolniki on the Dnieper”
Authors: Выбыванец Элеонора Васильевна 
Published: July 2022

Главной постановкой текущего сезона Краснодарского музыкального театра, входящего в состав Краснодарского творческого объединения «Премьера» имени Л. Г. Гатова, стала опера М. П. Мусоргского «Борис Годунов». Музыкальной основой спектакля явился авторский текст композитора, который был восстановлен в результате глубоких источниковедческих и текстологических изысканий. Благодаря взаимодействию научных консультантов Е. Левашева и Н. Тетериной с постановщиками, дирижером Д. Крюковым и режиссером О. Ивановой, была создана концептуально и конструктивно убедительная музыкально-сценическая версия, состоящая из восьми картин. В нее вошла никогда ранее не исполнявшаяся картина «Лесная прогалина под Сокольниками на Днепре», при этом была купирована сцена «Корчма на Литовской границе». Новая постановка изменила смысловые акценты в концепции оперы в соответствии с современными взглядами на исторические события. Отличительной чертой спектакля стали визуальные метафоры и лейтмотивы, эмоционально усиливающие действие, внезапно переключающие сценическое развитие, обнаруживающие тайные мысли персонажей.
The main production of the current season of the Krasnodar Musical Theatre, which is part of Gatov Krasnodar creative association "Premiere,” was the opera "Boris Godunov” by M. P. Mussorgsky. The musical basis of the performance was the author's text of the composer, which was restored as a result of deep source study and textual research. Thanks to the interaction of scientific consultants E. M. Levashev and N. I. Teterina with directors, conductor D. Kryukov and director O. Ivanova, a conceptually and structurally convincing musical stage version was created, consisting of eight scenes. It included the never-before-seen picture "Forest Glade near Sokolniki on the Dnieper,” while the scene "Tavern on the Lithuanian border” was cut off. The new production changed the semantic accents in the concept of the opera in accordance with modern views on historical events. A distinctive feature of the performance was visual metaphors and leitmotifs that emotionally enhance the action, suddenly switch the stage development, and reveal the secret thoughts of the characters.
Pedagogical Recommendations of Eliso Virsaladze on the Work on the Sonata-Fantasy “After Reading Dante” and the Piano Sonata in B Minor by Franz Liszt
Authors: Каприн Александр Дмитриевич 
Published: July 2022

Э. К. Вирсаладзе - профессор Московской государственной консерватории имени П. И. Чайковского, пианистка с более чем полувековым концертным стажем, ученица выдающихся музыкантов А. Д. Вирсаладзе, Г. Г. Нейгауза, Я. И. Зака, продолжающая их артистические и педагогические традиции. Ее преподавательская деятельность началась в 1967 году, еще во время обучения в аспирантуре Московской консерватории, и продолжается по сей день. В данной статье представлены рекомендации Э. К. Вирсаладзе по работе над произведениями Ф. Листа, имеющие высокую художественную и практическую ценность. Буквально по тактам она разбирает нюансы динамики, штрихов, аппликатуры фортепианных Сонаты-фантазии «По прочтении Данте» и Сонаты h-moll. Статья рекомендуется студентам музыкальных колледжей, училищ и вузов, а также всем интересующимся музыкантам.
E. K. VirsaLadze is a Professor at Tchaikovsky Moscow State Conservatory, a pianist with more than half a century of concert experience, a student of outstanding musicians A. D. Virsaladze, G. G. Neuhaus, Ya. I. Zak, continuing their artistic and pedagogicaL traditions. She began her teaching career in 1967, while still studying at the graduate school of Moscow Conservatory, and continues to this day. This article presents the recommendations of E. K. Virsaladze on working on the sonatas of the F. Liszt that have high artistic and practical vaLue. Literally by the measures, she anaLyzes the nuances of dynamics, strokes, fingerings of the Sonata-Fantasy “After Reading Dante” and the Piano Sonata in B minor. The articLe is recommended for students of music colleges, colleges and universities, as well as for all interested musicians.
Management of Exfoliative Cheilitis
Authors: Mersil Sarah , Limanda NIcholas 
Published: July 2022

Abstract: Cheilitis is an inflammation of the vermilion border of lips. Exfoliative cheilitis occurs on the upper and lower lips in the form of exfoliation of the keratinized surface’s lips, accompanied by redness and edema. We reported a 21-year-old female patient, a dental student, with a chief complaint of sores on the cracked lower and upper lips, and bleeding since two weeks ago. She was not sure when this condition started, but she had realized it for almost three years. The patient used to feel dry lips, therefore she licked and sucked her lips and then peeled the dry surface off. She did not drink enough water, did not like fruits and vegetables very well, and was allergic to certain lipsticks, so, she discontinued using it since one year ago. She treated her lips with lip balm, but it did not show any improvement. Extraoral examination showed that the lower lip was not covered by epithelia, there was a blackish red crust of 1 cm around the vermilion border mixed with exfoliating yellowish crust. Several fissures were seen on the upper and lower lips associated with erythema. This patient was diagnosed as exfoliative cheilitis and was managed with applying lip balm and triamcinolone acetonide 0.1%, twice a day that showed satisfying result. In conclusion, in managing exfoliative cheilitis, the causative factors have to be determined and controlled, and administration of topical steroid and moisturizer showed significant improvement.Keywords: exfoliative cheilitis; steroids Abstrak: Keilitis adalah adanya inflamasi pada vermilion border bibir. Kasus keilitis eksfoliatif terjadi pada bibir atas dan bawah berupa pengelupasan permukaan keratin bibir, disertai adanya kemerahan dan edema pada bibir. Kami melaporkan kasus seorang pasien perempuan 21 tahun, mahasiswi, dengan keluhan sariawan di bibir bawah dan atas tampak pecah-pecah, berdarah dan perih sejak dua minggu lalu. Tidak diketahui pasti sejak kapan kondisi ini dialami, namun mulai disadari sejak sekitar tiga tahun. Pasien sering merasa bibir kering, sering menjilat/menghisap bibir kemudian mengelupasnya. Kurang minum air, kurang menyukai buah-buahan dan sayur, serta alergi pemakaian lipstik tertentu dan sudah dihentikan sejak satu tahun lalu. Sudah melakukan pengobatan dengan lip balm, namun tidak menunjukkan perubahan. Pemeriksaan klinis ekstraoral menunjukkan sebagian besar bibir bawah tidak tertutupi epitel, terdapat krusta merah kehitaman ±1cm sekitar batas vermilion bercampur dengan krusta kekuningan hampir mengelupas (eksfoliasi). Beberapa fisur terlihat pada bagian bibir atas dan bawah disertai eritema. Pasien didiagnosis sebagai keilitis eksfoliatif. Penatalaksanaan dengan melanjutkan pemakaian lip balm dan pemberian obat oles bibir triamcinolone acetonide 0,1%, dipakai dua kali sebelum penggunaan lip balm yang memberikan hasil memuaskan. Simpulan kasus ini ialah dalam penatalaksanaan kasus keilitis eksfoliatif harus ditentukan faktor penyebab dan dikendalikan. Pemberian steroid topikal dan pelembab memberikan perbaikan yang berarti.Kata kunci: keilitis eksfoliatif; steroid
MODEL PENDIDIKAN ISLAM BAGI ANAK TERLANTAR (STUDI KASUS DI PONDOK PESANTREN METAL REJOSO PASURUAN JAWA TIMUR)
Authors: Mudrika Luk Ailik , Jamhuri M 
Published: July 2022

Model menurut kamus besar bahasa Indonesia adalah pola (contoh, acuan, ragam) dari suatu yang akan dibuat atau dihasilkan. Pendidikan Islam memiliki peran dan fungsi yanng sangat penting untuk pemenuhan iman seseorang khususnya bagi anak-anak. Pengaruh lingkungan dan perkembangan zaman yang mengakibatnya rawannya serta minimnya suatu pendidikan Islam bagi rohaninya. Adanya pendidikan Islam, anak akan mendapatkan suatu pegangan dan pedoman hidup serta bekal iman melalui pendidikan Islam yang didapatkan sejak dini. Melalui model pendidikan Islam yang benar akan menjadikan mereka menjadi anak yang memiliki rasa toleransi yang tinggi, dan memiliki ilmu agama yang cukup untuk bekal kehidupannya. Pondok Pesantren Metal Muslim al-Hidayah sebagai Yayasan LKS (Lembaga Kesejahteraan Sosial) Pondok Metal al-Hidayah menerapkan adanya model pendidikan Islam yang membentuk karakter kepribadian yang baik, dengan memiliki jiwa iman, Islam dan ihsan. Anak terlantar adalah anak yang karena alasan tertentu orang tuanya melalaikan kewajibannya, sehingga tidak terpenuhi kebutuhan dengan wajar baik secara fisik, mental, spiritual maupun sosialnya.
Berdasarkan hasil penelitian, Model Pendidikan Islam di Pondok Pesantren Metal ialah sebagai usaha untuk menanamkan iman yang kuat kepada para santri seperti kegiatan shalat berjamaah, shalat sunnah, menghafal al-Qur’an, mengaji al-Qur’an dan kitab-kitab. Nilai-nilai pendidikan islam yang terdapat adalah iman, Islam dan ihsan. Dampak bagi santri dari model pendidikan ini yaitu santri menjadi faham agama, mempunyai jiwa toleransi, hafal al-Qur’an, dan memiliki jiwa mandiri.