bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translating Research to Action: The Development of a Pediatric Palliative Cancer Care Advocacy Tool in Eurasia
Authors: Ehrlich Bella S. , Yakimkova Taisiya , Batmunkh Tsetsegsaikhan , Mishkova Volha , Movsisyan Narine , Kirgizov Kirill , Borisevich Marina , Kizyma Roman , Graetz Dylan E. , McNeil Michael J. , Vinitsky Anna , Smelov Vitaly , Corbex Marilys , Lam Catherine G. , Kaye Erica C. , Baker Justin N. , Agulnik Asya 
Published: January 2022

PURPOSE The Assessing Doctors' Attitudes on Palliative Treatment study was conducted in 11 Eurasian countries to assess physician knowledge of and structural barriers to integration of palliative care into pediatric oncology. After publication, regional collaborators identified the need to disseminate country-specific study results locally and provide policy recommendations to inform stakeholders. METHODS The Assessing Doctors' Attitudes on Palliative Treatment report was developed with Eurasian and St Jude pediatric palliative care and oncology experts to summarize study findings and deliver country-level data to local stakeholders. In parallel, an assessment was developed to explore how regional collaborators intend to use the report to improve local advocacy and dissemination of research findings. The country report and assessment were translated to English, Russian, and Mongolian. RESULTS Country-specific two-page reports display study findings on pediatric palliative care education, access to pediatric palliative care services, and barriers to and timing of integration with cancer care, alongside clinical and policy recommendations. These reports were distributed to collaborators in 11 countries. Assessment results (N = 30) demonstrated that regional collaborators planned to distribute the report to institutional and government stakeholders, aiming to increase access to pediatric palliative care services (77%), establish a community-based palliative care network (70%), and increase opportunities for specialization (70%). CONCLUSION We describe the development of an evidence-based advocacy tool to inform local health and education policy in Eurasia. This summary report of study findings, translated to local languages and adapted to a broader audience, is currently used to advocate for greater access and quality of palliative care for children with cancer. This work may serve as the basis for future dissemination efforts of scientific research.
Role of Endothelin-1 Receptors in Limiting Leg Blood Flow and Glucose Uptake During Hyperinsulinemia in Type 2 Diabetes
Authors: Young Benjamin E , Padilla Jaume , Finsen Stine H , Fadel Paul J , Mortensen Stefan P 
Published: January 2022

Abstract
Skeletal muscle insulin resistance is a hallmark of individuals with type 2 diabetes mellitus (T2D). In healthy individuals insulin stimulates vasodilation, which is markedly blunted in T2D; however, the mechanism(s) remain incompletely understood. Investigations in rodents indicate augmented endothelin-1 (ET-1) action as a major contributor. Human studies have been limited to young obese participants and focused exclusively on the ET-1 A (ETA) receptor. Herein, we have hypothesized that ETA receptor antagonism would improve insulin-stimulated vasodilation and glucose uptake in T2D, with further improvements observed during concurrent ETA + ET-1 B (ETB) antagonism. Arterial pressure (arterial line), leg blood flow (LBF; Doppler), and leg glucose uptake (LGU) were measured at rest, during hyperinsulinemia alone, and hyperinsulinemia with (1) femoral artery infusion of BQ-123, the selective ETA receptor antagonist (n = 10 control, n = 9 T2D) and then (2) addition of BQ-788 (selective ETB antagonist) for blockade of ETA and ETB receptors (n = 7 each). The LBF responses to hyperinsulinemia alone tended to be lower in T2D (controls: ∆161 ± 160 mL/minute; T2D: ∆58 ± 43 mL/minute, P = .08). BQ-123 during hyperinsulinemia augmented LBF to a greater extent in T2D (% change: controls: 14 ± 23%; T2D: 38 ± 21%, P = .029). LGU following BQ-123 increased similarly between groups (P = .85). Concurrent ETA + ETB antagonism did not further increase LBF or LGU in either group. Collectively, these findings suggest that during hyperinsulinemia ETA receptor activation restrains vasodilation more in T2D than controls while limiting glucose uptake similarly in both groups, with no further effect of ETB receptors (NCT04907838).
Making Queer Asiatic Worlds: Performance and Racial Interaction in North American Visual Novels
Authors: Patterson Christopher B. 
Published: January 2022

AbstractThis paper argues that video games expose the presumptions separating “Asian America” and “Asia” in the traditional senses of isolation, origination, and presumed distance. It does so by focusing on the most “Asiatic” genre of video games today, the North American visual novel, which offers a counterdiscourse to normative modes of play and attempts to offer utopic spaces to reflect upon the “real” genres of race and neo–Cold War geopolitics. Using theories of performance from Dorinne Kondo and others, the author shows how queer indie visual novels are primarily aspirational, in that they build queer, utopic, and seemingly anti-racist worlds through the Asiatic space of the visual novel form. In so doing, they also allow players to explore the Asiatic as a means of repairing the traumas and distances of American imperial cultures. The article analyzes four visual novels to make this argument: three by non-racially-identifying North American designers—Doki Doki Literature Club! (2017) by Dan Salvato, Analogue: A Hate Story (2012) by Christine Love, and Heaven Will Be Mine (2018) by Aevee Bee—and Butterfly Soup (2017), a game by the queer Asian/American designer Brianna Lei. If games make the boundaries of Asia and America irrelevant, visual novels explore this irrelevance through Asiatic irreverence.
Authentic-Deconstructionist Games and Tragic Historiography in Assassin’s Creed III
Authors: Joyce Stephen 
Published: January 2022

Abstract
This paper examines the historiographic potential of video games with Assassin’s Creed III (2012) as a paradigmatic example that shows the aesthetic and political challenges games face in telling counterhistories of marginalized peoples. The article argues that Ubisoft’s Assassin’s Creed series, perhaps the premier historical gaming franchise, has developed an authentic-deconstructionist genre that offers convincing simulacra of historical places and events while using games’ multimedia affordances to question how historical knowledge is constructed. In Assassin’s Creed III, this authentic-deconstructionist method is applied to the story of an Indigenous man trying to protect his tribe from white settlers during the American Revolution. However, the game is critically weakened by the historiographic problem of emplotting this tragic tale in the heroic epic of the nation’s founding. This narrative disjunction is exacerbated by the medium’s lack of an internal aesthetic tradition of tragedy to draw on; mainstream games are generally contests of skill in which success brings victory, rather than the defeat necessary for a tragic outcome. However, despite its weaknesses, the game and its transmedia expansions sparked widespread discussions about Indigenous peoples during this historical period and helped advance gaming as a serious medium for critical perspectives on American history.
Gaming Borders: The Rhetorics of Gamification and National Belonging inPapers, Please
Authors: Kafer Gary 
Published: January 2022

AbstractGame media have long participated in projects of nation building by remediating historical, political, and social relations in ways that reinforce affective processes of national belonging. The genre of border games in particular is well-known for staging the discursive and symbolic value of national boundaries through the deployment of specific gameplay mechanics and storytelling elements. However, as this essay argues, border games do more than merely represent borders in games; they reflect how borders themselves might be experienced as games within the cultural logic of gamification. Through an analysis of Lucas Pope’s independently produced American video game Papers, Please (2013), this article interrogates gamification as a rhetorical process that communicates how play dynamics sustain the procedural logics of border security and citizenship. Such logics, the game suggests, are marked by the installment of a series of rule-based interactions that modulate affect within the sociotechnical mechanics of state-sanctioned racism to enable the proper flow of both play and mobility. However, through failure, the game also reveals gamification to be an incomplete diagram of control, one where the priming of affect rubs up against the sociopolitical frictions that shape individual play experiences. Ultimately, this article argues that border games like Papers, Please enable players to experiment with the forms of national belonging that subtend our experiences of gamification.
Burr Hole Microsurgery for Middle Cerebral Artery Aneurysms: A Clinical Case Series
Authors: Lepsveridze Levan , Semenov Maksim , Stepanyan Georgy , Abudeev Sergey 
Published: January 2022

BACKGROUND:
Minimally invasive microsurgery has become popular in neurosurgery. Burr hole microsurgery is another more modern minimally invasive technique that allows surgical treatment of various intracranial pathologies through an extreme small craniotomy. This article presents the first application of the burr hole approach for microsurgical clipping of cerebral aneurysms.

OBJECTIVE:
To assess the feasibility and outcomes of using the burr hole microsurgical technique in cerebral aneurysm surgery.

METHODS:
From March 2020 to August 2020, 3 patients with unruptured middle cerebral artery aneurysms underwent burr hole microsurgical clipping.

RESULTS:
Three patients with middle cerebral bifurcation aneurysms were successfully treated. The duration of surgery was from 62 to 83 min (median 72.5). Postoperatively, no new neurological symptoms, complications, or mortality were observed in all the cases.

CONCLUSION:
Burr hole microsurgery is an advanced neurosurgical method. Although the surgery is performed through a small burr hole approximately 14 mm in size, safe and successful treatment of normal-sized middle cerebral artery aneurysms using standard microsurgical principles and technique is possible.
Long-Term Cryopreservation of Ready-to-Use DNA-Modified Gold Nanoparticle Derivatives: Effect of Preservation Temperature on Their DNA Dissociation and Functional Stability
Authors: Juji Shotaro , Oishi Motoi 
Published: January 2022

Abstract
The effect of preservation temperature on the DNA dissociation and functional stability of two types of DNA-modified gold nanoparticles (GNPs) was studied. The cryopreservation of both GNPs for 56 days has fully prevented the DNA dissociation and maintained the toehold-mediated DNA displacement reaction capacity without any aggregation of GNPs.
Iatrogenic stroke caused by cerebral air embolism and acute reperfusion therapy using hyperbaric oxygen
Authors: Strømsnes Torbjørn Austveg , Røed Ine , Strøm Hanna , Advani Rajiv , Biernat Donata , Ihle-Hansen Hege 
Published: January 2022

Objective: Air embolisms are mostly iatrogenic and a rare yet dreaded complication following percutaneous procedures. Intravascular entrapment of air can result in occlusion of end arteries and subsequent tissue ischemia and infarction. Cerebrovascular occlusions caused by air embolisms are time-sensitive and an uncommon cause of ischemic stroke, warranting an alternative acute management and reperfusion strategy. Methods: During a CT-guided lung biopsy, the patient developed left-sided paresis and sensory deficits prior to loss of consciousness. CT revealed air in the aorta, both ophthalmic arteries and vessels in the right parietal region. The patient was swiftly air-lifted to the nearest hyperbaric oxygen chamber for an alternate emergency reperfusion therapy. The following eight days the patient received hyperbaric oxygen therapy and gradually improved. Nine days after symptom onset he was discharged with a minor left facial palsy. Conclusions Cerebrovascular occlusions are critical events regardless of etiology. Air embolism is rare but potentially catastrophic and can occur during both percutaneous procedures and surgeries. Vigilance and knowledge of this potential complication are needed to rapidly provide beneficial treatment. That is, high flow oxygen and correct positioning pending hyperbaric oxygen therapy.
Variability in size at maturity of the European anchovy (Engraulis encrasicolus) in the Mediterranean Sea
Authors: FERRERI ROSALIA , GENOVESE SIMONA , BARRA MARCO , BIAGIOTTI ILARIA , BOURDEIX JEAN-HERVE , De FELICE ANDREA , GAŠPAREVIĆ DENIS , HATTAB TAREK , IGLESIAS MAGDALENA , JURETIĆ TEA , LEONORI IOLE , MALAVOLTI SARA , RAYKOV VIOLIN ST , SARAUX CLAIRE , TIČINA VJEKOSLAV , VENTERO ANA , BASILONE GUALTIERO 
Published: January 2022

Size at first sexual maturity (L50) represents an important life history trait in the development of management measures providing fundamental information to avoid the exploitation of younger individuals. L50 is known to display variability due to fishing pressure, geographical gradient and environmental features. In this study, in order to investigate L50 variability among areas of the Mediterranean and Black Sea, maturity ogives of anchovy (Engraulis encrasicolus) were estimated by considering samples collected during the anchovy spawning period in the framework of the MEDiterranean International Acoustic Survey (MEDIAS) program. Anchovy size and sexual maturity data from several Geographical Sub-Areas (GSA) – i.e. Northern Spain, Gulf of Lion, Tyrrhenian Sea, Strait of Sicily, Adriatic Sea and Black Sea – were gathered according to a standard methodological protocol. Maturity ogives were estimated by means of a logistic regression taking into account total length, condition factor, sex and GSA. Obtained results evidenced a significant effect of condition factor, fish in better condition reaching maturity earlier, as well as differences in L50 values among areas and between sexes, with males reaching the maturity at lower length than females. Even though the obtained L50 estimates are relative to the spawning period only, the observed variability at the Mediterranean basin scale highlights the importance to explicitly consider the habitat peculiarities in order to provide management advices based on an ecosystem approach to fishery.
Expansion of gelatinous macrozooplankton in the open Black Sea off Crimea under the weather events of recent years
Authors: ANNINSKY BORYS E. , FINENKO GALINA A. , DATSYK NATALYA A. , HUBAREVA ELENA S. 
Published: January 2022

Species composition, abundance, and distribution of gelatinous macroplankton in coastal and deep-sea areas of the Black Sea in November 2017 are discussed. Despite the fact that species composition of gelatinous macroplankton (medusa Aurelia aurita, ctenophores Mnemiopsis leidyi, Pleurobrachia pileus, and Beroe ovata) in 2017 did not differ from that in 2016, structural changes occured. In autumn 2017 A. aurita and B. ovata biomass was higher than in 2016 whereas the inverse difference was observed in their abundance values. Namely, A. aurita biomass was on average 514 g m-2 and 634 g m-2 in the outer shelf and deep-sea areas, respectively. Both parameters of M. leidyi and P. pileus declined in 2017 compared to the previous year. In addition, the share of large-sized individuals increased in 2017, while that of small-sized animals decreased, in comparison with 2016. The number of small individuals increased in P. pileus and decreased in M. leidyi, although their biomass before the seasonal appearance of B. ovata in plankton was close to that in 2016. The unprecedented increase in the medusae biomass in November 2017 could not be explained only by the competition with planktivorous ctenophores and may indicate alternative drivers controlling population dynamics of A. aurita in the Black Sea. A negative correlation was depicted between the Danube discharge in February-March and the rate of somatic growth of A. aurita.
Working Paper 5: Poverty and corruption
Authors: Koechlin Lucy 
Published: January 2022

The Millennium Development Goals were adopted by the global community under the aegis of the UN in 2000. The first of these goals aims at halving absolute poverty of the about 1.1 billion people who live on less than 1 US dollar a day.
Although poverty reduction has always been an important concern of development policy, the Millennium Development Goals have brought it back onto centre stage with renewed vigour, in that joint efforts to reduce poverty worldwide has become a moral as well as financial obligation of the global community. Just a glance at the global development indicators reveals how urgent the renewed efforts to fight extreme poverty, especially – and not surprisingly – in least developed countries.
According to the UN statistics the number of persons living in extreme poverty has decreased slightly between 1990 and 2001; but it is still estimated that worldwide still approximately one billion people live on less than 1 US dollar a day.
Working Paper 6: Managing proceeds of asset recovery
Authors: Jimu Ignasio 
Published: January 2022

This paper looks at the use of proceeds of asset recovered from Sani Abacha, Vladimir Montesinos, and Ferdinand Marcos and their families. It will also briefly address a much more recent case involving Kazakhstan.
Repatriation of stolen monies makes available additional resources for development activities. The challenge is to ensure efficient, accountable and transparent use of such assets, given states may lack capacity or political will and that corruption may be prevalent at various levels of government.
Transparency allows for better utilisation of recovered assets, and better targeting of resources into sectors that have potential to benefit the victims of corruption, who happen to be mostly the poor. Lack of effective follow up mechanisms may lead to the inappropriate allocation of resources into sectors that have little effect on alleviating poverty.
The cases under review here offer lessons on how to manage repatriation and utilisation of proceeds of asset recovery. Further lessons relate to the participation of third parties and the benefits of making the results of the entire process public.
Working Paper 11: A framework to assess governance of health systems in low-income countries
Authors: Baez Camargo Claudia , Jacobs Eelco 
Published: January 2022

As awareness of the role governance in the performance of health systems has increased, so has the need to come up with systematic means to evaluate governance shortcomings to develop adequate interventions.
This working paper describes a framework to assess governance in the health systems of low-income countries that is intended to have empirical applicability with a problem-driven approach. The analysis is grounded on a re-categorization of governance dimensions for greater heuristic power, with an emphasis made on the importance of strategic systems design and accountability.
The proposed methodology includes mapping of both formal and informal institutions, actors and networks. This underscores the idea that in order to properly address governance weaknesses it is of utmost importance to have an insight into whether the interplay of formal and informal norms facilitates or undermines system performance.
Working Paper 9: The situation of Financial Intelligence Units in Central and Eastern Europe and the former Soviet Union
Authors: Strauss Kilian 
Published: January 2022

The transition process in many countries in Central and Eastern Europe from a one-party state to a democratic system has been long and difficult and has frequently been accompanied by institutional instability.
The judiciary and law enforcement bodies have been no exception. Both have suffered from a weak legal tradition in many countries of the region, weak implementation of existing legislation, limited operational effectiveness, corruption and the influence of informal personal networks. These developments can also be observed in the area of financial intelligence.
Following the fall of the Berlin wall in 1989 and the events of September 2001, most countries of the region adopted legislation aimed at combating money laundering and terrorist financing, as required by their international commitments as well as EU entry requirements. In this context, most countries also set up the required institutions, notably a Financial Intelligence Unit (FIU).
Working Paper 1: Anti-money laundering
Authors: Aiolfi Gemma , Pieth Mark 
Published: January 2022

Switzerland is frequently accused of being reluctant to take thorough measures to fight money laundering. Both the Swiss authorities and the banks in Switzerland strongly reject such accusations. We are convinced that our anti-money laundering measures are best market practice.
What are the reasons for these markedly different viewpoints? Can they be explained by conceptual differences? Are the negative statements the result of insufficient knowledge of our legal provisions, or are they simply motivated by the political desire of the respective commentators to divert public attention from the deficient anti-money laundering policies in their own countries?
A comparison of our measures with the most important competing financial centres could help to answer these questions. The SFS Stiftung Finanzplatz Schweiz – a foundation initiated by the foreign banks in Switzerland – commissioned Professor Mark Pieth of the Basel Institute on Governance to conduct a comparative study of anti-money laundering regulations in the UK, the US and Singapore, the three financial centres which closely compete with the Swiss private banking sector. Professor Pieth is a renowned expert in the field and has close contacts with the international experts who also contributed to the project with in-depth country studies.
Working Paper 20: Corruption and human rights
Authors: Peters Anne 
Published: January 2022

It is a fact that states with a high corruption rate (or a high corruption perception) are at the same time those with a bad human rights situation. Beyond this coincidence, the paper seeks to identify a concrete legal relationship between corruption and deficient human rights protection. This seems relevant and practical terms, because the extant international norms against corruption have so far yielded only modest success; their implementation could be improved with the help of human rights arguments and instruments.
This paper therefore discusses a dual question:

Can corrupt behaviour be conceptualised as a human rights violation?
Should corrupt behaviour be categorised and sanctioned as a human rights violation?

The author's answer is that such a juridic reconstruction is plausible under specific conditions, especially for petty corruption, but that we should be aware of the risks of such reframing of the issue.