bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicentre study with real-world data of the use of palbociclib in the treatment of breast cancer: Treatment duration correlates with dose reductions
Authors: Musicco Felice , Lasala Ruggero , Santoleri Fiorenzo , Costantini Alberto , Abrate Paolo , Carretta Maria Teresa , Proli Enrica Maria , Romagnoli Alessia , Petragnani Nicola , Vita Francesco De , Zeuli Massimo , Vici Patrizia , Sansone Massimo , Pasquantonio Matilde , La Malfa Antonia , Fulgenzio Chiara 
Published: July 2022

Objective Palbociclib, a highly selective reversible CDK4-6 kinase inhibitor, is indicated in combination with an aromatase inhibitor or in combination with fulvestrant in women who had received prior endocrine treatment. Studies have demonstrated the efficacy of palbociclib in combination with fulvestrant in increasing progression-free survival in patients who relapsed or progressed on previous endocrine therapy, or in combination with aromatase inhibitor in patients who had not received previous treatments. We analysed the prescribing patterns of palbociclib in real practice correlating it with the evidence of treatment-related toxicity management and to time-to-treatment discontinuation and treatment adherence. Methods For the observational, retrospective study, data were collected from five Italian hospital centres that prescribed palbociclib between April 2017 and April 2020. Each centre provided data derived from an administrative database of adult patients treated with palbociclib for the two therapeutic indications. Treatment adherence was calculated using the proportion of days covered method while time-to-treatment discontinuation was defined as the difference between the first and last date treatment was administered plus the days ideally covered by the last date treatment was given. Results There were 375 patients enrolled during the study period, of whom 159 were treated with palbociclib and aromatase inhibitor and 216 were treated with palbociclib and fulvestrant. The time-to-treatment discontinuation was 8.9 months in the case of P + f (95% CI: 7.1−12.7) and 13.7 months in the case of P + ia (95% CI: 8.9−17.5). In both cohorts, treatments that received at least one dose reduction had a statistically higher time-to-treatment discontinuation than those without dose reduction (17.7 months vs. 9.2 and 16.6 vs. 7.4). The mean adherence in our study was 0.9 and remained high in treatments with one dose reduction (0.83) and this with two dose reductions (0.87). Conclusion Based on these findings, it appears that the management of toxicities through reducing doses, as required by the Summary of Product Characteristics, results in a better outcome in terms of therapy duration, and therefore time to failure due to progression or toxicity.
Trends in the surgical treatment of posterior shoulder instability in the United States from 2016 to 2020
Authors: Lemme Nicholas J , Bokshan Steven L , Yang Daniel , Meghani Ozair , Alsoof Daniel , Lau Brian C , Daniels Alan H , Owens Brett D 
Published: July 2022

Background The purpose of this study was to describe trends in the incidence of open versus arthroscopic management of posterior shoulder instability (PSI) as well as the patients undergoing these procedures in the United States over time. Methods The PearlDiver Patient Records Database was utilized for this study. Cases of PSI and surgery were identified via the appropriate ICD-10-CM and CPT codes. Linear regression and two-sample Student's t-test were used to analyze incidence rates, procedure type, number of instability events, and patient age. Results A total of 5655 patients were identified as having PSI, undergoing a total of 686 capsulorraphies. The incidence of PSI treated surgically increased across the years of the study at a rate of 0.0293 per 100,000 person-years with an incidence in 2019–2020 greater than in 2016–2018 ( p = 0.0151). Patients undergoing arthroscopic capsulorrhaphy were on average younger than those undergoing open capsulorrhaphy ( p = 0.0021). Patients experienced a higher number of posterior instability events before open surgery compared to arthroscopic ( p = 0.0274). Discussion The incidence of surgical treatment of PSI in the United States is steadily rising, with greater than 90% of cases being treated arthroscopically. Those undergoing arthroscopic posterior stabilization are both younger and face fewer instability events prior to surgery.
Peptide nanogels as a scaffold for fabricating dermal grafts and 3D vascularized skin models
Authors: Arab Wafaa T , Susapto Hepi H , Alhattab Dana , Hauser Charlotte A E 
Published: July 2022

Millions of people worldwide suffer from skin injuries, which create significant problems in their lives and are costly to cure. Tissue engineering is a promising approach that aims to fabricate functional organs using biocompatible scaffolds. We designed ultrashort tetrameric peptides with promising properties required for skin tissue engineering. Our work aimed to test the efficacy of these scaffolds for the fabrication of dermal grafts and 3D vascularized skin tissue models. We found that the direct contact of keratinocytes and fibroblasts enhanced the proliferation of the keratinocytes. Moreover, the expression levels of TGF-β1, b-FGF, IL-6, and IL-1α is correlated with the growth of the fibroblasts and keratinocytes in the co-culture. Furthermore, we successfully produced a 3D vascularized skin co-culture model using these peptide scaffolds. We believe that the described results represent an advancement in the fabrication of skin tissue equivalent, thereby providing the opportunity to rebuild missing, failing, or damaged parts. Graphical abstract [Formula: see text]
Children’s health insurance coverage and adequacy from 2016 to 2018: Racial/ethnic disparities under the ACA
Authors: Shen Yuying , Turner Carlene Buchanan , Perkins Robert K , Moore Ami 
Published: July 2022

Background: This study advances health disparities research by documenting the racial/ethnic disparities in children’s health insurance coverage and health insurance adequacy under the implementation and revisions of the Affordable Care Act between 2016 and 2018 in America. Design and methods: Combining the nation-wide repeated cross-sectional data from 2016 to 2018 Children’s Health National Survey (NSCH), we examined the changes and trends of health insurance coverage and health insurance adequacy among children age 0–17 across different racial/ethnic groups from 2016 to 2018. Multivariate logistic regression models stratified by race-ethnicity were further analyzed to examine the association between children’s health insurance adequacy, their health insurance coverage, and their socio-demographic background factors. Results: Our analyses indicate that generally children’s enrollment in Medicaid or other government aided health care programs had been increasing whereas children’s enrollment in the employer-based had been decreasing from 2016 to 2018. At the same time, the number of children who said that they always had adequate health insurance to meet their health care needs has slightly dropped from 2016 to 2018, except for AIAN children. Our analyses further revealed that the risk of inadequate health insurance appears to be stronger for children in disadvantaged situation, socially and economically. Conclusions: The ACA has contributed to expanding childhood health insurance coverage. But racial/ethnic disparities continue to exist in children’s health insurance coverage and health insurance adequacy. To achieve equity in childhood health care, more outreach and appropriate programs are needed for children who are socially and economically disadvantaged.
Effects of Limb Dominance on Patellofemoral Joint Loading During Gait at 12 Weeks After Anterior Cruciate Ligament Reconstruction
Authors: Goto Shiho , Garrison J. Craig , Singleton Steven B. , Dietrich Lindsey N. , Hannon Joseph P. 
Published: July 2022

Background: Patellofemoral joint complications have commonly been reported in long-term outcome studies for anterior cruciate ligament reconstruction (ACLR); however, the biomechanics in the early phases of rehabilitation that could be associated with the development of these abnormalities is unclear. Limb dominance may affect the biomechanics of the knee joint in patients after ACLR. Purpose: To compare knee joint loading between surgical and nonsurgical limbs at 12 weeks postoperatively in patients who underwent ACLR on either their dominant limb (ACL-D) or nondominant limb (ACL-ND). Study Design: Controlled laboratory study. Methods: Included were 54 patients (32 ACL-D and 22 ACL-ND). Peak and integrated patellofemoral joint stress (PFJS), peak patellofemoral joint reaction force (PFJRF), and peak knee extension moment (KEM) were assessed during the stance phase of gait while participants walked on a 10-m runway at a self-selected speed. Results: The surgical limb of the ACL-D group had significantly decreased peak PFJS ( P < .001), integrated PFJS ( P < .001), peak PFJRF ( P < .001), and peak KEM ( P < .001) compared to the nonsurgical limb. The surgical limb of the ACL-ND group demonstrated significantly increased peak PFJS ( P = .001), integrated PFJS ( P = .023), peak PFJRF ( P < .001), and peak KEM ( P = .001) compared to the nonsurgical limb. For the surgical limb, the ACL-ND group demonstrated significantly greater peak PFJS ( P < .001), peak PFJRF ( P < .001) , (PFJRF [ P<.001]) and peak KEM ( P < .001) than the ACL-D group. For the nonsurgical limb, the ACL-D group demonstrated greater peak PFJS ( P < .001), integrated PFJS ( P = .023), peak PFJRF ( P = .003), and peak KEM ( P < .001) than the ACL-ND group. Conclusion: Significantly larger knee joint loading on the surgical limb of the ACL-ND group and smaller knee joint loading on the surgical limb of the ACL-D group were observed compared to the contralateral nonsurgical limb, which suggests that limb dominance has a key role in loading at the knee joint during gait. Clinical Relevance: Altered knee joint loading during gait at 12 weeks after ACLR may lead to the development of patellofemoral joint abnormalities.
Pregnant and Powerless: Exploring Barriers to Contraceptive use among Women in Mogadishu, Somalia
Authors: Gele Abdi A , Shrestha Mary , Sheikh Naima Said , Qureshi Samera A 
Published: July 2022

Background With a maternal mortality ratio of 692 per 100 000 live births and modern contraception prevalence of 1%, understanding factors hindering Somali women from using modern contraception is key to developing and implementing locally adopted public health responses. The purpose of this qualitative study was to explore factors impeding Somali women in Mogadishu from using modern contraception Methods We conducted a qualitative study using semi-structured, in-depth interviews with 21 married women aged >18 years, living in different neighborhoods in Mogadishu between July—December 2018. We recruited the participants using a convenience sampling method. Results The findings show that health communication messages and contraceptive information provided by health providers (medical barriers) constitute a significant obstacle to women’s access to modern contraception services. Other barriers included prevalent religious fallacies among women and fear of permanent infertility upon modern contraception. Conclusion Training health providers in the principles of modern contraception, in addition to the medical ethics that govern their responsibility to provide correct and relevant information to their patients, is vital for increasing modern contraception use among Somali women. The findings of this study may be used for designing public health interventions that promote acceptance and the use of modern contraception among both women and men in Somalia.
Midwives’ Knowledge and Preparedness in Providing Maternity Care During COVID-19 Pandemic in Dodoma Region, Tanzania: A Cross-Sectional Study
Authors: Abdalla Subira , Joho Angelina A. 
Published: July 2022

Background COVID-19 pandemic has a high impact on the health of pregnant women and healthcare providers worldwide. Objective This study aims to assess midwives’ knowledge and preparedness in providing maternity care during COVID-19 pandemic. Methods A cross-sectional analytical hospital-based study that included 116 midwives, who were working in labor ward, was conducted in the Dodoma region of Tanzania from March to June 2021. The Chi-square test and Fisher's exact test were used to assess the association between the categorical variables. The predictors of midwives’ knowledge and preparedness were determined using binary logistic regression analysis. Statistical analysis was performed using SPSS version 23.0; p < .05 was considered to be significant. Results Of the midwives studied, 63 (54.3%) had adequate knowledge about COVID-19 and only 30 (25.9%) were adequately prepared on provision of maternal care. Having diploma/bachelor level of education (AOR  =  2.62, 95%CI  =  1.08–6.36, p  =  .033), being trained on COVID-19 (AOR  =  3.65, 95%CI  =  1.11–12.00, p  =  .033) and working in urban health facilities (AOR = 3.65, 95%CI  =  1.17–13.98, p  =  .002) were the significant determinants of midwives’ knowledge on COVID-19. Working at a health center (AOR  =  0.19, 95%CI  =  0.03–1.32. p  =  .033), being trained on COVID-19 (AOR  =  0.04, 95%CI  =  0.01–0.14, p  =  .000 and having adequate knowledge on COVID-19 (AOR  =  0.20, 95%CI  =  0.03–1.32, p  =  .032) were determinants of midwives’ preparedness on provision of maternal care. Conclusion Knowledge and preparedness in the provision of maternity care during the COVID-19 pandemic were low. Emphasis should be put on training midwives on IPC when providing maternity care. This may help in preventing the spread of infectious diseases including COVID-19 as we observed in the present study.
Nursing Students Perceptions of Using YouTube to Teach Psychomotor Skills: A Comparative Pilot Study
Authors: Burton Richard 
Published: July 2022

Introduction Current techniques to teach psychomotor skills to nursing students involve the traditional modeled performance by an instructor followed by rote memorization and practice. This outdated model presents many issues including no reference to refer back to, lacks technology integration, and only meets a few learning styles. A developmental study utilizing the social media platform YouTube was examined to gain student’s perspective on this as a teaching tool to assist in skill acquisition. Objective Do nursing students, who are enrolled in a Bachelor of Science Nursing (BSN) program and who are taught psychomotor nursing skills via demonstration on the social media platform YouTube, prefer this technology to traditional demonstration, and to evaluate their overall perceptions of YouTube? Methods Data collection was done utilizing a nursing cohort enrolled in a BSN program. Participants were split into two groups. The control group was taught intravenous (IV) skills in the traditional teacher demonstration followed by practice. Experimental group was given access to a YouTube video series consisting of the identified IV skills. After testing for competency was concluded, control group was given access to the videos. A questionnaire was developed and sent out for evaluation. Results Participants reported that their preferred learning style when learning new nursing skills was visual (41.7%) followed by a combination of visual, tactile, and auditory (41.7%). All respondents (100%) reported YouTube videos increased their learning. Respondents (100%) also noted that having access to the videos better prepared them. In experimental group, all participants (100%) watched the videos, and in the control group, only (16.7%) of students watched the videos after the skill had been learned. Conclusion Results demonstrated that students prefer YouTube videos when learning new skills. They reported feeling better prepared to learn. YouTube is a potential way to increase skill acquisition and integrate technology into the nursing curriculum.
Olanzapine/Samidorphan: A New Option for the Treatment of Adults With Schizophrenia or Bipolar I Disorder
Authors: Pham Huy , Warlick Halford , Bermudez Ricardo , Nguyen Quan , Rey Jose A. 
Published: July 2022

Objective: To review the pharmacology, pharmacokinetics, and efficacy and safety data of a combination of olanzapine and samidorphan (OLZ/SAM) for the treatment of schizophrenia and bipolar I disorder, which mitigates the possible unwanted side effects of weight gain associated with olanzapine (OLZ). Data Sources: The review was done with a bibliographic survey of studies using MEDLINE/PubMed (January 1999-May 2021) database using the keywords olanzapine and samidorphan. Abstracts, scientific posters, and information from the manufacturer’s product labeling were evaluated for inclusion. Inclusion criteria: phase 2, phase 3, and open-labeled studies that evaluated the use of OLZ/SAM for the treatment of schizophrenia and bipolar I disorder. Data Synthesis: We have included one phase 2 dose-ranging exploratory study, two phase 3 efficacy and safety studies, and several open-label extension studies without a comparator. For the treatment of schizophrenia, OLZ/SAM and OLZ alone were analyzed in 2 randomized, double-blind comparison studies of approximately 960 patients. Analysis indicated that OLZ (5-20 mg)/SAM (10 mg) significantly mitigated the side effect of weight gain compared with OLZ alone (control) while maintaining antipsychotic efficacy. For bipolar I disorder, OLZ/SAM was approved as an acute treatment for manic or mixed episodes, as well as an adjunct to valproate or lithium for manic/mixed episodes based on bridging strategy allowed by the Food and Drug Administration. Relevance to Patient Care and Clinical Practice: The combination of olanzapine and samidorphan demonstrated efficacy for the treatment of schizophrenia with a dosage range of 5 to 20 mg OLZ to a 10-mg fixed dose of samidorphan. Advantages of this drug combination include once-daily dosing, favorable tolerability, and most importantly, mitigation of weight gain, which may encourage adherence, when compared with OLZ alone. Conclusion: The new combination treatment of OLZ/SAM is a unique antipsychotic formulation to provide the recognized efficacious treatment of OLZ, while mitigating the weight gain and possibly the weight-related adverse effects secondary to OLZ monotherapy.
Cardiac cephalalgia: a case series of four patients and updated literature review
Authors: Kobata Hitoshi 
Published: July 2022

Abstract
Background
Cardiac damage is common in patients with acute brain injury; however, little is known regarding cardiac-induced neurological symptoms. In the International Classification of Headache, Third Edition (ICHD-III), cardiac cephalalgia is classified as a headache caused by impaired homeostasis.

Methods
This report presents four patients with acute myocardial infarction (AMI) who presented with headache that fulfilled the ICHD-III diagnostic criteria for cardiac cephalalgia. A systematic review of cardiac cephalalgia using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines is also presented.

Results
Case 1: A 69-year-old man with a history of percutaneous coronary intervention (PCI) developed sudden severe occipital pain, nausea, and cold sweating. Coronary angiography (CAG) revealed occlusion of the right coronary artery (RCA). Case 2: A 66-year-old woman complained of increasing occipitalgia and chest discomfort while riding a bicycle. CAG demonstrated 99% stenosis of the left anterior descending artery. Case 3: A 54-year-old man presented with faintness, cold sweating, and occipitalgia after eating lunch. CAG detected occlusion of the RCA. Case 4: A 72-year-old man went into shock after complaining of a sudden severe headache and nausea. Vasopressors were initiated and emergency CAG was performed, which detected three-vessel disease. In all four, electrocardiography (ECG) showed ST segment elevation or depression and echocardiography revealed a left ventricular wall motion abnormality. All patients underwent PCI, which resulted in headache resolution after successful coronary reperfusion. A total of 59 cases of cardiac cephalalgia were reviewed, including the four reported here. Although the typical manifestation of cardiac cephalalgia is migraine-like pain on exertion, it may present with thunderclap headache without a trigger or chest symptoms, mimicking subarachnoid hemorrhage. ECG may not always show an abnormality. Headaches resolve after successful coronary reperfusion.

Conclusions
Cardiac cephalalgia resulting from AMI can present with or without chest discomfort and even mimic the classic thunderclap headache associated with SAH. It should be recognized as a neurological emergency and treated without delay.
Mixture density networks for the indirect estimation of reference intervals
Authors: Hepp Tobias , Zierk Jakob , Rauh Manfred , Metzler Markus , Seitz Sarem 
Published: July 2022

AbstractBackgroundReference intervals represent the expected range of physiological test results in a healthy population and are essential to support medical decision making. Particularly in the context of pediatric reference intervals, where recruitment regulations make prospective studies challenging to conduct, indirect estimation strategies are becoming increasingly important. Established indirect methods enable robust identification of the distribution of “healthy” samples from laboratory databases, which include unlabeled pathologic cases, but are currently severely limited when adjusting for essential patient characteristics such as age. Here, we propose the use of mixture density networks (MDN) to overcome this problem and model all parameters of the mixture distribution in a single step.ResultsEstimated reference intervals from varying settings with simulated data demonstrate the ability to accurately estimate latent distributions from unlabeled data using different implementations of MDNs. Comparing the performance with alternative estimation approaches further highlights the importance of modeling the mixture component weights as a function of the input in order to avoid biased estimates for all other parameters and the resulting reference intervals. We also provide a strategy to generate partially customized starting weights to improve proper identification of the latent components. Finally, the application on real-world hemoglobin samples provides results in line with current gold standard approaches, but also suggests further investigations with respect to adequate regularization strategies in order to prevent overfitting the data.ConclusionsMixture density networks provide a promising approach capable of extracting the distribution of healthy samples from unlabeled laboratory databases while simultaneously and explicitly estimating all parameters and component weights as non-linear functions of the covariate(s), thereby allowing the estimation of age-dependent reference intervals in a single step. Further studies on model regularization and asymmetric component distributions are warranted to consolidate our findings and expand the scope of applications.