bluuebunny/crossref_metadata_2025_split huggingface dataset:
Радянська Україна 1930 р. (за публікаціями часопису «Діло»)
Authors: Житарюк Марʼян 
Published: May 2022

У статті систематизовано публікації про радянську Україну у львівському часописі «Діло» 1930 р. Виокремлено й узагальнено важливі питання політичного, національно-культурного життя, економічного й соціального становища, релігійних та історичних проблем, як-от: більшовизм, колективізація на теренах радянської України, Спілка Визволення України, реформа освіти тощо.
Переосмислено болючі питання українського національного життя в умовах радянського поневолення в міжвоєнний період на основі газетних публікацій. Протягом 30-х рр. ХХ ст. надруковано тисячі матеріалів, які потребують уважного прочитання, осмислення, вивчення. Так, у газеті «Діло» протягом 1930 р. подано понад дві сотні публікацій про життя в радянській Україні, зокрема, 120 – опис, оцінка подій та ситуацій на радянщині авторства журналістів і дописувачів «Діла», головно представників Східної Галичини, 5 – зарубіжних авторів, решту – реакція-протест у Західній Україні та світі на трагедію українців.
Мета статті – зосередити увагу на ключових національних питаннях в умовах радянської України протягом 1930 р. Завдання публікації – осмислити виявлені тексти в контексті планомірного знищення національної суті українців, а також доповнити історію української журналістики новою джерельною базою (новими публікаціями) і бібліографічними даними.
Методологічна основа дослідження. У статті використано метод наукового опрацювання першоджерел, знайдених у спецфондах Наукової бібліотеки ЛНУ ім. І. Франка, зокрема, підшивок газети «Діло» за 1930 р. Опрацьовано 252 публікації, частина з яких – у кількох подачах. На основі наукового реферування виокремлено 6 публікацій з ключовими словами «СВУ», «колективізація», «більшовицький терор», «Радянська Україна» (метод наукового пошуку), тобто фактично застосовано проблемно-тематичний аналіз з метою осмислення порушених проблем (концептуальний аналіз) і підготування певних висновків та узагальнень (методи синтезу, індукції й дедукції). Статтю проілюстровано двома таблицями, підготовленими з допомогою кількісного аналізу та контент-аналізу.
З допомогою нових текстів у «Ділі» доповнено, розкрито, уточнено окремі питання історії української журналістики та увиразнено розуміння трагічних подій, систематизовано публікації як джерела осмислення відображення більшовицької політики нищення України, життя в умовах радянської України.
Доки ми є, – ніщо не програно
Authors: Матвійчук Анатолій 
Published: May 2022

Зникає довіра до наших популярних інформаційних джерел і топовим телеканалам. Вони давно зрадили своєму основному призначенню – доносити правду без жодного викривлення і маніпуляції фактами. Схоже, це стало неможливим – на цьому нині заробляються мільярди.
За допомогою саме інформації змінюється майбутня доля всього людства. Тому телеканали, радіостанції, інформаційні агентства та інтернет-портали сьогодні – найбільш жадані і ласі придбання всіх світових багатіїв. Саме вони створюють ту бажану реальність, просувають потрібні тренди і заповнюють інформаційний простір потрібними їм креатурами – від поп-зірок до політиків. Це і є нині суть «вільної преси».
Excessive Consumption of Garlic as a Nutraceutical may Lead to Transient Coagulopathy-First report
Authors: Bansal Parveen , Bansal Nahush Roop , Khillan Ratesh 
Published: May 2022

Garlic is a commonly used spice with multiple health benefits. There are numerous active ingredients in garlic, like organosulphur compounds, saponins, phenolic compounds, and polysaccharides, which can affect the various pathways in the human body through different mechanisms. The positive effects of garlic like preventing hypertension, maintaining a healthy lipid profile, decreasing body fat and many others are well known. This one-dimensional knowledge has led people to consume garlic excessively as a nutraceutical. It is imperative to spread awareness about the potential derangements that unregulated consumption of garlic can exert on the human body so that people can strike a perfect balance and understand the safe limits for garlic consumption. We are presenting first report of a peculiar case of coagulopathy induced due to excessive dietary consumption of garlic. The features of this coagulopathy were its mild severity, asymptomatic presentation, and reversibility after cessation of garlic intake. This abnormality probably occurred due to various interactions at the molecular level between the clotting factors and the bioactive compounds in garlic. As such, intake of garlic may require supervision in patients with an elevated risk of bleeding.
Keywords: Garlic, Nutraceutical, coagulopathy, Clotting factors.
Peran Terapi Akupunktur pada Kondisi Leukopenia Kanker Payudara Pasien Kemoterapi
Authors: NARESWARI I , HARYOKO N.R. , MIHARDJA HASAN 
Published: May 2022

Breast cancer is a malignant disease that has the highest against women. Management of breast cancer that is currently done is a combination of surgery and chemotherapy, because in addition to effective therapy, but also can extend the recurrence. Chemotherapy given a systemic therapy that has serious side effects, one of which the effects of myelosuppression. Leukopenia is a condition that requires proper treatment and immediately, because it can cause dose reductions and delays in chemotherapy. Medication is given on the condition of chemotherapy-induced leukopenia one of which is the provision of Granulocyte Stimulating Factor (G-CSF), but these drugs have side effects, and requires a high cost. Based on several studies, acupuncture is effective in treating conditions due to the effects of chemotherapy leukopenia, and give excellent results. Acupuncture can stimulate the formation of CSF thereby increasing the number of leukocytes in the blood and improve the function of hematopoiesis in bone marrow.ABSTRAK Kanker payudara merupakan penyakit keganasan yang menyerang wanita dan menduduki peringkat tertinggi. Tatalaksana kanker payudara yang saat ini banyak dilakukan adalah kombinasi pembedahan dan kemoterapi, karena terapi tersebut selain efektif, juga dapat memperpanjang masa kekambuhan. Kemoterapi yang diberikan merupakan terapi sistemik yang mempunyai efek samping cukup serius, salah satunya efek myelosupresi. Leukopenia merupakan kondisi yang memerlukan penanganan tepat dan segera, karena dapat menyebabkan penurunan dosis dan penundaan kemoterapi. Salah satu medikasi yang diberikan pada kondisi leukopeni akibat kemoterapi adalah pemberian Granulocyte Stimulating Factor (G-CSF). Namun, obat ini mempunyai efek samping dan membutuhkan biaya yang tinggi. Berdasarkan beberapa penelitian yang dilakukan, akupunktur efektif dalam mengatasi kondisi leukopenia akibat efek kemoterapi dan memberikan hasil yang sangat baik. Akupunktur dapat merangsang pembentukan CSF sehingga meningkatkan jumlah leukosit dalam darah dan memperbaiki fungsi hematopoiesis di sumsum tulang.
Three-Dimensional Cartilage Regeneration Using Engineered Cartilage Gel With a 3D-Printed Polycaprolactone Framework
Authors: Wu Gaoyang , Lu Lixing , Ci Zheng , Wang Yahui , Shi Runjie , Zhou Guangdong , Li Shengli 
Published: May 2022

The feasibility of the three-dimensional (3D) cartilage regeneration technology based on the “steel (framework)-reinforced concrete (engineered cartilage gel, ECG)” concept has been verified in large animals using a decalcified bone matrix (DBM) as the framework. However, the instability of the source, large sample variation, and lack of control over the 3D shape of DBM have greatly hindered clinical translation of this technology. To optimize cartilage regeneration using the ECG–framework model, the current study explores the feasibility of replacing the DBM framework with a 3D-printed polycaprolactone (PCL) framework. The PCL framework showed good biocompatibility with ECG and achieved a high ECG loading efficiency, similar to that of the DBM framework. Furthermore, PCL-ECG constructs caused a milder inflammatory response in vivo than that induced by DBM-ECG constructs, which was further supported by an in vitro macrophage activation experiment. Notably, the PCL-ECG constructs successfully regenerated mature cartilage and essentially maintained their original shape throughout 8 weeks of subcutaneous implantation. Quantitative analysis revealed that the GAG and total collagen contents of the regenerated cartilage in the PCL-ECG group were significantly higher than those in the DBM-ECG group. The results indicated that the 3D-printed PCL framework—a clinically approved biomaterial with multiple advantages including customizable shape design, mechanical strength control, and standardized production—can serve as an excellent framework for supporting the 3D cartilage regeneration of ECG. This provides a feasible novel strategy for the clinical translation of ECG-based 3D cartilage regeneration.
Transcatheter Aortic Valve Implantation: A Report on Serbia's First Systematic Program
Authors: Boljevic Darko , Bojic Milovan , Farkic Mihajlo , Sagic Dragan , Topic Dragan , Kovacevic Vladimir , Lakcevic Jovana , Veljkovic Stefan , Dobric Milan , Hinic Sasa , Ilijevski Nenad , Nikolic Marko , Kaludjerovic Aleksandra , Bunc Matjaz , Nikolic Aleksandra 
Published: May 2022

IntroductionSevere aortic stenosis, a highly-common valve disease in the elderly, has a poor prognosis if left untreated. To address the concern of effective procedures for severe aortic stenosis, a systematic TAVI program was established at the Dedinje Cardiovascular Institute (Belgrade, Serbia).MethodsOur cohort was composed of 56 patients (74±15 years old). The mean logistic EuroScore was 10.17%; the mean Society of Thoracic Surgeons score was 3.22%. One third of the patients were categorized as class III or IV of the New York Heart Association (NYHA). The valves selected for use were either self-expandable or balloon expandable (Evolut R, Medtronic; Acurate Neo, Boston Scientific and Myval, Meril). The choice of valve type was made by the Institute's Structural Heart Team, in accordance with the patient's native aortic valve, size and calcification of ilio-femoral vessels, as well as the need for alternative access. TAVI procedure was conducted according to current guidelines provided by the European Society of Cardiology.ResultsThe procedure success rate was 100%. Trans-femoral approach was achieved in 100% of patients; percutaneously in 87.5%, while a surgical cut was necessary in 12.5%. No patient showed moderate or severe aortic regurgitation after the procedure, although trace or mild regurgitation was recorded in 30.3%. Permanent pacemaker was implanted in one patient (1.78%), contrast induced acute kidney injury occured in one patient (1.78%), no stroke was recorded, and three pseudo-aneurysms which required surgical intervention occurred. Three patients required blood transfusions (5.33%). A 30-day all-cause mortality rate was 1.78%.ConclusionThe Dedinje Cardiovascular Institute spearheaded all efforts to establish a TAVI program in Serbia. Our initial TAVI results are promising, encouraging, and comparable with the results of previous large randomized trials. This initial experience opens the door for further development with a goal of our Institute to become a high-volume TAVI center.
Hypothalamic Kisspeptin Neurons Regulates Energy Metabolism and Reproduction Under Chronic Stress
Authors: Huang Yinqiong , Liu Qinyu , Huang Guifeng , Wen Junping , Chen Gang 
Published: May 2022

BackgroundStress activates the hypothalamic-pituitary-adrenal (HPA) axis, affecting energy homeostasis and reproduction. The aim of this study was to investigate whether stress affected energy metabolism and reproduction through the glucocorticoid receptor on Kisspeptin neurons in the hypothalamus.MethodsFour groups included control group, chronic restraint stress group, Kisspeptin specific glucocorticoid receptor knock out group (KGRKO) and KGRKO+stress group. Body weight, food intake, estrous cycle of female mice, serum sex hormone levels, serum corticosterone and prolactin, Kisspeptin expression in the hypothalamus were measured.ResultsThe restraint stress group showed a significant weight loss compared with the control group. KGRKO+restraint stress group had a reduced weight loss, suggesting that restraint stress might partially affect the energy metabolism through GR on Kisspeptin neurons. In terms of reproductive function, the restraint stress group and the KGRKO+restraint stress group showed missing pre-estrus period or prolonged estrous cycles. Serum LH and FSH in KGRKO + restraint stress group decreased significantly compared with KGRKO group. However, no significant difference in the level of serum testosterone was observed. After restraint stress, the levels of serum cortisol and prolactin in male and female mice were significantly higher than the control group, and the hypothalamus Kiss1 gene mRNA expression and Kisspeptin protein expression were significantly decreased.ConclusionChronic restraint stress induced weight loss and negative changes in reproduction, which were partially mediated by glucocorticoid receptor on Kisspeptin neurons in the hypothalamus.
Birthweight After Frozen Embryos Formed on the Fifth Day Versus the Sixth Day: A Retrospective Analysis Including 17,127 Singleton Newborns
Authors: Yang Junlan , Wang Ze , Cao Hairu , Liu Lu , Yuan Qiaona , Xu Haiyan , Tang Rong 
Published: May 2022

BackgroundTransferring blastocysts frozen on day 6 (D6) may adversely affect the pregnancy rate compared with day 5 (D5). Moreover, it remains unclear whether delayed embryo transfer affects neonatal birth weight.MethodsA retrospective cohort study consisting of 17,127 singleton births from single frozen embryo transfer (FET) cycles, between January 2011 and January 2020, was performed including 14,166 blastocysts frozen on D5 and 2,961 on D6. The primary outcomes of this study were neonatal birth weight and incidence of small for gestational age (SGA), large for gestational age (LGA), low birth weight (LBW), and macrosomia.ResultsThe mean neonatal birth weight in the D5 group (3.47 ± 0.49 kg) was significantly higher compared with the D6 group (3.45 ± 0.50 kg), although the discrepancy was only 0.02 kg. Multiple linear regression analysis for birth weight between the two groups showed no statistically significant difference (β= -0.01 t= -1.218; P&gt;0.05). Logistic regression analysis revealed that the risks of SGA (OR 1.166; 95%CI, 0.911-1.491; P&gt;0.05), LGA (OR 0.917; 95%CI, 0.831-1.012; P&gt;0.05), LBW (OR 1.192; 95%CI, 0.926-1.533; P&gt;0.05), and macrosomia (OR 0.975; 95%CI, 0.864-1.100; P&gt;0.05) were similar in the two groups after adjusting for confounders.ConclusionsIn the FET cycle, the neonatal birth weight and incidence of LGA, SGA, LBW, or macrosomia were similar between the D5 and D6 groups, suggesting that delayed blastocyst transfer would not affect the neonatal birth weight.
Global, Regional, and National Burden of Low Bone Mineral Density From 1990 to 2019: Results From the Global Burden of Disease Study 2019
Authors: Dong Yimin , Kang Honglei , Peng Renpeng , Song Kehan , Guo Qian , Guan Hanfeng , Zhu Meipeng , Ye Dawei , Li Feng 
Published: May 2022

ObjectiveWe aim to explore the global spatial prevalence and temporal trends of the burden of low bone mineral density (LBMD) worldwide, due to a lack of related studies.DesignCross-sectional study.MethodsWe used data from the Global Burden of Disease Study 2019 to conduct this study. LBMD in the GBD study includes both osteopenia and osteoporosis. The estimation for the prevalence, measured by the summary exposure value (SEV), and burden of LBMD was made in DisMod-MR 2.1, a Bayesian meta-regression tool. Correlation analysis was performed using the Spearman rank order correlation methods. The temporal trends were represented by the estimated annual percentage change (EAPC).ResultsIn 2019, there were 438 thousand deaths and 16.6 million DALYs attributable to LBMD, increasing by 111.1% and 93.8% respectively, compared to that in 1990. From 1990 to 2019, the prevalence of LBMD has decreased worldwide, but has increased in high-income North America. Some countries, such as the United States, Australia, Canada, and China had increased disability and mortality rates of LBMD with time. Countries with low socio-demographic index (SDI) had higher incidence and mortality rate than those with high SDI. The prevalence of LBMD was lower in males, but the attributable disability and mortality were higher in males in all years from 1990 to 2019.ConclusionWith population aging, countries worldwide, especially those with low-SDI, will face increasing challenges in reducing the burden attributable to LBMD and osteoporosis. The treatment of osteoporosis has been overlooked in men for a long time. Effective measures are warranted to control the prevalence and burden of LBMD.
A Validated Model for Individualized Prediction of Live Birth in Patients With Adenomyosis Undergoing Frozen–Thawed Embryo Transfer
Authors: Wu Yaoqiu , Yang Rong , Lin Haiyan , Cao Chunwei , Jiao Xuedan , Zhang Qingxue 
Published: May 2022

PurposeThis study aimed to develop a predictive tool for live birth in women with adenomyosis undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment.MethodsA total of 424 patients with adenomyosis who underwent frozen–thawed embryo transfer (FET) from January 2013 to December 2019 at a public university hospital were included. The patients were randomly divided into training (n = 265) and validation (n = 159) samples for the building and testing of the nomogram, respectively. Multivariate logistic regression (MLR) was developed on the basis of clinical covariates assessed for their association with live birth.ResultsIn total, 183 (43.16%) patients became pregnant, and 114 (26.88%) had a live birth. The MLR showed that the probability of live birth was significantly correlated with age [odds ratio (OR), 3.465; 95% confidence interval (CI), 1.215–9.885, P = 0.020], uterine volume (OR, 8.141; 95% CI, 2.170–10.542; P = 0.002), blastocyst transfer (OR, 3.231; 95% CI, 1.065–8.819, P = 0.023), twin pregnancy (OR, 0.328; 95% CI, 0.104–0.344, P = 0.005), and protocol in FET (P &lt; 0.001). The statistical nomogram was built based on age, uterine volume, twin pregnancy, stage of the transferred embryo, and protocol of FET, with an area under the curve (AUC) of 0.837 (95% CI: 0.741–0.910) for the training cohort. The AUC for the validation cohort was 0.737 (95% CI: 0.661–0.813), presenting a well-pleasing goodness-of-fit and stability in this model.ConclusionsThis visual and easily applied nomogram built on the risk factors of live birth in patients with adenomyosis provides useful and precise information for physicians on individualized decision-making during the IVF/ICSI procedure.
Identification of Novel Genetic Variants and Comorbidities Associated With ICD-10-Based Diagnosis of Hypertrophic Cardiomyopathy Using the UK Biobank Cohort
Authors: Gyftopoulos Alex , Chen Yi-Ju , Wang Libin , Williams Charles H. , Chun Young Wook , O’Connell Jeffery R. , Perry James A. , Hong Charles C. 
Published: May 2022

Objectives: To identify previously unrecognized genetic variants and clinical variables associated with the ICD-10 (International Classification of Diseases 10)-based diagnosis of hypertrophic cardiomyopathy in the UK Biobank cohort.Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disorder with more than 2000 known mutations in one of eight genes encoding sarcomeric proteins. However, there is considerable variation in disease manifestation, suggesting the role of additional unrecognized contributors, genetic and otherwise. There is substantial interest in the use of real-world data, such as electronic health records to better understand disease mechanisms and discover new treatment strategies, but whether ICD-10-based diagnosis can be used to study HCM genetics is unknown.Methods: In a genome-wide association study (GWAS) using the UK Biobank, we analyzed the genomes of 363 individuals diagnosed with HCM based on ICD-10 coding compared to 7,260 age, ancestry, and sex-matched controls in a 1:20 case:control design. Genetic variants were analyzed by Plink’s firth logistic regression and assessed for association with HCM. We also examined 61 biomarkers and other diagnoses in the 363 HCM cases and matched controls.Results: The prevalence of ICD-10-based diagnosis of HCM in the UK Biobank cohort was 1 in 1,342, suggesting disease assignment based on the two ICD-10 codes underestimates HCM prevalence. In addition, common cardiovascular comorbidities were more prevalent in ICD-10-based HCM cases in comparison to controls. We identified two novel, non-sarcomeric genetic variants in KMT2C rs78630626, and PARD3B rs188937806 that were associated with ICD-10 codes for HCM with genome-wide significance (p &lt; 5 x 10−8). These are associated with an increased odds ratio (OR) of ∼3.8 for being diagnosed with HCM. Minor allele frequency (MAF) of each variant was &gt;1%.Discussion: Disease assignment based strictly on ICD-10 codes may underestimate HCM prevalence. Individuals with HCM were more frequently diagnosed with several comorbid conditions, such as hypertension, atherosclerotic heart disease, diabetes, and kidney failure, suggesting they may contribute to disease manifestation. This UK Biobank database-based GWAS identified common variants in KMT2C and PARD3B that are associated with HCM diagnosis, which may represent novel modifier genes. Our study demonstrates the feasibility and limitations of conducting phenotypic and genotypic characterization of HCM based on ICD-10 diagnosis in a large population-based cohort.
An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers
Authors: Lan Chungen , Ni Bo , Zhao Tiansuo , Li Zekun , Wang Junjin , Ma Ying , Li Weidong , Wang Xiuchao 
Published: May 2022

Background: YAP, coded by YAP1 gene, is critical in the Hippo pathway. It has been reported to be involved in the tumorigenesis and progression of several cancers. However, its roles on tumor cell proliferation in diverse cancers remain to be elucidated. And there is currently no clinically feasible drug that can directly target YAP in cancers. This research aimed to explore the regulatory mechanism of YAP in promoting tumor proliferation of multiple cancers, in order to find new strategies for inhibiting the overgrowth of YAP-driven cancers.Methods: We investigated the expression pattern of YAP1 in pan-cancer across numerous databases and our cohorts. First, univariate Cox regression analysis and survival analysis were used to evaluate the effect of YAP1 on the prognosis of cancer patients. Second, TIMER was used to explore the relationship between YAP1 expression and tumor cell proliferation. Third, functional and pathway enrichment was performed to search for targets of YAP involved in cell cycle in cancers. At last, GDSC and CCLE datasets were used to assess the correlation between SKP2 expression and MLN4924 IC50 values.Results: Differential expression analysis of multiple databases and qPCR validation showed that YAP1 was generally overexpressed in pan-cancers. Survival analysis revealed that YAP1 over-expression was significantly related to poor prognosis of patients with PAAD. The expression level of YAP1 was positively correlated with the proliferation in varieties of tumors. Further, SKP2 was confirmed as a target of YAP in promoting tumor cell proliferation. In addition, SKP2 expression was negatively correlated with MLN4924 IC50 values in almost all cancer types.Conclusion:YAP1 is frequently overexpressed in human cancers. YAP promoted tumor cell proliferation by up-regulating SKP2 expression in multiple cancers. The comprehensive pan-cancer analysis suggested that inhibition of Skp2 with MLN4924 might be an effective therapeutic strategy for attenuating tumor cell proliferation in YAP-driven cancers.