bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulatory effect of pomegranate extract on TRPA1, TRPM2 and caspase-3 expressions in colorectal cancer induction of mice
Authors: Kaya İnan , Dağ Serpil , Mavioğlu Kaya Müge , Tanrıverdi Erdi Anil , Beşeren Hatice , Aşasın Gizem 
Published: August 2022

Abstract

Objectives
This study aimed to evaluate the effects of pomegranate fruit extract (PFE) on levels of transient receptor potential (TRP) channel and caspase-3 (Casp-3) expressions, tumor necrosis factor-α (TNF-α), total sialic acid (TSA), reduced glutathione (GSH), and malondialdehyde (MDA) in mice with induced colorectal cancer (CRC) by investigating effects of PFE on in vitro mitotic index (MI).

Methods
Different PFE concentrations on​​ MI against 0.3 μg/mL mitomycin-C (MMC) in cell culture were evaluated by binocular light microscopy. During in vivo applications on Balb/c mice, it was given once physiological saline to group I, PFE for ten weeks to group II, a single dose of azoxymethane (AOM) plus dextran sulfate sodium in drinking water (DSS) to group III, and AOM plus DSS plus PFE to group IV. Tissue samples were evaluated by western blotting, spectrophotometric, and histopathological methods.

Results
Expressions of Casp-3, TRP ankyrin 1 (TRPA1), and melastatin 2 (TRPM2) channels and TNF-α, TSA, GSH, and MDA concentrations in evaluated tissues had significantly better levels in PFE-treated groups compared to CRC-induced mice.

Conclusions
Results of the present study indicate that PFE application in mice with induced CRC may be an important modulator of TRPA1 and TRPM2 channels, apoptosis, and inflammatory response by decreasing oxidative stress.
Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex
Authors: Upton Brian A. , Nayak Gowri , Schweinzger Ivy , D’Souza Shane P. , Vorhees Charles V. , Williams Michael T. , Earl Brian R. , Lang Richard A. 
Published: August 2022

AbstractOpsin-3 (Opn3, encephalopsin) was the first nonvisual opsin gene discovered in mammals. Since then, severalOpn3functions have been described, and in two cases (adipose tissue, smooth muscle) light sensing activity is implicated. In addition to peripheral tissues,Opn3is robustly expressed within the central nervous system, for which it derives its name. Despite this expression, no studies have investigated developmental or adult CNS consequences ofOpn3loss-of-function. Here, the behavioral consequences of mice deficient inOpn3were investigated.Opn3-deficient mice perform comparably to wild-type mice in measures of motor coordination, socialization, anxiety-like behavior, and various aspects of learning and memory. However,Opn3-deficient mice have an attenuated acoustic startle reflex (ASR) relative to littermates. This deficit is not because of changes in hearing sensitivity, although Opn3 was shown to be expressed in auditory and vestibular structures, including cochlear outer hair cells. Interestingly, the ASR was not acutely light-dependent and did not vary between daytime and nighttime trials, despite known functions ofOpn3in photoreception and circadian gene amplitude. Together, these results demonstrate the first role ofOpn3on behavior, although the role of this opsin in the CNS remains largely elusive.
Low muscle mass and high visceral fat mass predict mortality in patients hospitalized with moderate-to-severe COVID-19: a prospective study
Authors: Beltrão Fabyan Esberard de Lima , Beltrão Daniele Carvalhal de Almeida , Carvalhal Giulia , Beltrão Fabyo Napoleão de Lima , de Aquino Igor Motta , Brito Thaíse da Silva , Paulino Barbara Costa , Aires Elisa , Viegas Diana , Hecht Fabio , Halpern Bruno , Pordeus Liana Clebia De Morais , Gonçalves Maria da Conceição Rodrigues , Ramos Helton Estrela 
Published: August 2022

Introduction
The severity of coronavirus disease 2019 (COVID-19) has been positively correlated with several comorbidities. The primary outcome of the study was to assess the relationship between the mortality and severity of COVID-19 and obesity classes according to BMI, visceral adipose tissue (VAT) area, s.c. adipose tissue area, muscle area (MA), and leptin levels.

Methods
In this prospective cohort study, 200 patients hospitalized with moderate-to-severe COVID-19 underwent an unenhanced CT of the thorax and laboratory tests, and leptin levels between June and August 2020 were obtained.

Results
Our study included 200 patients (male 52%; mean age: 62 (49–74) years; obesity (BMI > 30): 51.5%)). Fifty-eight patients (23.5%) were admitted to the intensive care unit and 29 (14.5%) died. In multivariate logistic regression (corrected for leptin, sex, age, and serum biomarkers) and receiver operating characteristic curve analyses, high VAT > 150 cm2 (odds ratio (OR): 6.15; P < 0.002), MA < 92 cm2 (OR: 7.94; P < 0.005), and VAT/MA ratio > 2 (OR: 13.9; P < 0.0001) were independent risk factors for mortality. Indeed, the Kaplan–Meier curves showed that patients with MA < 92 cm2 and without obesity (BMI < 30) had a lower survival rate (hazard ratio between 3.89 and 9.66; P < 0.0006) than the other groups. Leptin levels were not related to mortality and severity.

Conclusion
This prospective study reports data on the largest number of hospitalized severe COVID-19 patients and pinpoints VAT area and MA calculated by CT as predictors of COVID-19 mortality.
Perspektywa uczniowska, rodzicielska i nauczycielska - trzy spojrzenia na edukację zdalną. Badanie w działaniu w czasie pandemii wirusa SARS-CoV-2
Authors: Piekarska Karolina 
Published: August 2022

Cel. Tekst przedstawia wyniki badań zrealizowanych w okresie: grudzień 2020 – marzec 2021. Ich celem było poznanie trzech perspektyw dotyczących odbioru edukacji zdalnej w okresie pandemii wirusa SARS-CoV-2: perspektywy uczniów klas 4-8 szkoły podstawowej, perspektywy rodziców, perspektywy nauczycieli; sformułowanie wniosków z badań i stworzenie na ich podstawie materiału edukacyjnego ze wskazówkami dotyczącymi tego, jak można o siebie zadbać w czasie kryzysu, a także co należy uwzględnić podczas organizowania edukacji online w przyszłości.
Metodologia. Przeprowadzone badania zostały osadzone w strategii jakościowej, w schemacie badania w działaniu. Wybraną metodą zbierania danych był wywiad indywidualny częściowo kierowany, natomiast narzędziem: autorskie kwestionariusze wywiadu dla trzech grup: nauczycieli, uczniów oraz ich rodziców. Do badań zaproszono trzy rodziny oraz czworo nauczycieli. W rozmowach z badanymi uzyskano odpowiedzi na pytania dotyczące m.in. sposobów realizacji zajęć zdalnych, funkcji szkoły, oczekiwań, pozytywnych i negatywnych aspektów kształcenia online, samopoczucia, sfery zawodowej i życia prywatnego. Na podstawie uzyskanych informacji oraz naukowych źródeł stworzono materiał edukacyjny „Edukacja zdalna – jak się odnaleźć”. Udostępniono go w formie pdf Kujawsko-Pomorskiemu Kuratorium Oświaty, rozmówcom oraz dziewięćdziesięciu siedmiu szkołom.
Wyniki. Z przeprowadzonych badań wynika, że każda osoba zauważyła więcej negatywnych aspektów edukacji zdalnej niż pozytywnych, a także doświadczyła nieprzyjemnych dolegliwości zarówno ze strony fizycznego, jak i psychicznego samopoczucia. Stworzony materiał edukacyjny natomiast stał się praktyczną pomocą szczególnie dla rodziców oraz nauczycieli.
Wnioski. Edukacja zdalna niesie z sobą więcej negatywnych skutków niż pozytywnych. Obciąża swym ciężarem zarówno dzieci, jak i dorosłych, jednak szczególne zagrożenie stanowi dla rozwoju społecznego i emocjonalnego młodych ludzi.
Buda, a keleties város
Authors: Papp Adrienn 
Published: August 2022

Az oszmán hódítással egy teljesen új kultúra jelent meg Budán, aminek az intézményi hálózatát ekkor kellett megteremteni. Budán semmi sem volt meg, amit egy oszmán elvárt városaitól, amire a mindennapi élethez szüksége volt. Nem volt dzsámi, Korán-iskola, fürdő stb., ezeket mind létre kellett hozniuk, és az intézmények épületeket igényeltek. A jelentős új épületek, melyek oszmán stílus szerint készültek, a külvárosokban jelentek meg, a Várhegy őrizte középkori megjelenését. A Várhegyen a középkori épületek új funkciót kaptak, oszmán intézményeknek adtak teret. Elsőként a templomokból kellet dzsámit csinálni, ami azok teljes belső átalakítását jelentette. Utána sorban megtalálták a többi feladathoz rendelhető helyet, középkori épületet használtak az iskolák, a közkonyha, a fedett piac számára. Amit mindenképp újonnan kellett még a Várhegyen is megépíteni, az a fürdő és a síremlék. Ezek mind szükségesek ahhoz, hogy egy oszmán város működjön, így azt látjuk, hogy a korszak legelején mindent megépítettek vagy átalakítottak, amire szükségük volt, jelentősebb változás csak új városnegyedek kialakulása miatt tapasztalható.
A vári házakba oszmánok költöztek, bár a 16. században még 122 család élt itt, a korszak végére gyakorlatilag teljesen elköltöztek a Várhegyről a magyar lakosok. A lakóházak kisebb átalakításokon estek át, jelentős bontást és teljesen új épületegyüttes kiépítését a pasa palota esetében figyelhetünk meg.
Towards better control of chemical risks associated with mining operations in Quebec (Canada) Part 1: Repertory of chemicals used in mining
Authors: Biyick Paul-Patrice , Badri Adel , Gauthier François 
Published: August 2022

Abstract
As of 2020, the mining industry in the province of Quebec (Canada) has been providing 16,000 jobs, the majority of these in the north part of the province and in the Abitibi-Témiscamingue region. From the exploration phase to the mining site rehabilitation phase, numerous chemical processes are used, often involving some of the most dangerous substances used on industrial scales.
The hazards associated with many of these substances are in some cases not obvious, and symptoms of exposure may take years to appear. The risks associated with the industrial use of chemicals in Canada and abroad has long preoccupied health authorities, given the severity of the diseases that can occur. In Quebec, occupational diseases associated with exposure to industrial chemicals are reaching 1,500 cases per year.
The principal focus of this study, presented in two articles, is to set a preliminary theoretical framework for categorizing chemicals in terms of their effects on the health of workers throughout the various phases of mining projects. The objective is to decrease (over the long term) the number of occupational diseases due to the use of chemicals by raising awareness among employers and exposed workers in the mining sector.
This research was conducted in four phases. The present article contains the results of the first two stages, that is, a review of the literature to catalog the industrial chemicals used in mines and to list the potential effects of exposure to them, based on Safety Data Sheets. Eighty-five (85) chemicals used in at least one mining project phase and dozens of potential effects on worker health were identified. The rest of the study is presented in a second article [1]
Funga faloide e floriforme (Phallales, Basidiomycota) no Estado da Bahia, Brasil
Authors: Ribeiro Mateus Santana , Cabral Tiara Sousa , Melanda Gislaine Cristina Souza , Baseia Iuri Goulart , Silva Bianca Denise Barbosa da 
Published: August 2022

A ordem Phallales abriga fungos gasteroides conhecidos como chifres-fedidos, falsas trufas, gaiolas-de-bruxa e véus-de-noiva, e é caracterizada principalmente pelo cheiro fétido do basidioma, mecanismo de dispersão associado a insetos e gleba mucilaginosa. A ordem tem sido bem estudada no Brasil, com maior ocorrência nas regiões Sul e Nordeste do país. O Estado da Bahia apresenta apenas registros das espécies Abrachium floriforme e Lysurus sphaerocephalum. O objetivo deste estudo é apresentar novas ocorrências de Phallales para o Estado. As espécies foram coletadas na Bahia, nos municípios de Elísio Medrado, Mucugê, Salvador e Uruçuca. Um espécime herborizado coletado em Lençóis foi incluído nas análises. Sete espécies foram identificadas: Abrachium floriforme, Itajahya galericulata, Mutinus caninus, M. elegans, M. verrucosus, Phallus denigricans e P. merulinus. Todas representam novas ocorrências para o Estado da Bahia, com exceção de A. floriforme. Descrições, chave de identificação, notas e fotos das espécies são disponibilizadas.
Relationships to land as a determinant of wellness for Indigenous women, two-spirit, trans, and gender diverse people of reproductive age in Toronto, Canada
Authors: Jubinville Danette , Smylie Janet , Wolfe Sara , Bourgeois Cheryllee , Berry Nicole S. , Rotondi Michael , O’Brien Kristen , Venners Scott 
Published: August 2022

Abstract
Objective
Disparities in Indigenous reproductive health reflect Canada’s historic and ongoing colonial relationship with Indigenous peoples, which includes persistent inequities in health and social services. Reproductive justice scholars and activists advocate for intersectional approaches to enhancing Indigenous health equity that recognize land as a central determinant of wellness. The purpose of this study is to examine the association between relationships to land and wellness in a study of urban Indigenous women, two-spirit, trans, and gender diverse people of reproductive age in Canada’s largest city, Toronto.

Methods
Data were obtained from the cross-sectional Our Health Counts (OHC) Toronto study, which employed respondent-driven sampling methods (n = 323) and a community-directed comprehensive health assessment survey. In an exploratory analysis, we took an Indigenous reproductive justice theoretical approach to multivariable logistic regression.

Results
After adjusting for covariates, there was a statistically significant positive association between relationships to the land and wellness that was estimated with good precision (OR 3.7, 95% CI 2.5–5.3).

Conclusion
Our findings indicate that among urban Indigenous women, two-spirit, trans, and gender diverse people of reproductive age there is a positive association between feeling strong in their relationships to land and feeling balanced in the four domains of health (physical, spiritual, mental, and emotional). The community-based, community-directed design of OHC Toronto was congruent with a reproductive justice approach to research. Reproductive justice theories are adaptable to quantitative research on Indigenous reproductive health and can yield novel insights for supporting Indigenous wellness.
Law enforcement practice of territorial bodies of military police in criminal proceedings
Authors: Пасько Н.Э. 
Published: August 2022

В статье проводится анализ деятельности территориальных органов военной полиции в рамках уголовного процесса. Отдельное внимание уделено правоприменительной практике. Рассмотрено нормативное регламентирование их служебной деятельности. Обнаружен ряд коллизий, имеющих системный характер. Сделан вывод о необходимости своевременного совершенствования существующей нормативно-правовой базы.
The article analyzes the activities of the territorial bodies of the military police in the framework of criminal proceedings. Special attention is paid to law enforcement practice. The normative regulation of their official activity is considered. A number of collisions of a systemic nature have been detected. The conclusion is made about the need for timely improvement of the existing regulatory framework.
New introduction of electronic document management in the field of labor relations
Authors: Кожихин А.П. 
Published: August 2022

Рассматриваются новые правовые положения о внедрении в сферу трудовых отношений электронного документооборота на основании изменений в Трудовом кодексе Российской Федерации, внесённых Федеральным законом от 22 ноября 2021 года № 377-ФЗ. Подчёркивается объективная обусловленность указанных новаций активным развитием цифровой экономики и расширением применения в деятельности хозяйствующих субъектов цифровых технологий. Показываются появляющиеся возможности взаимодействия сторон трудовых отношений - работодателя и работника с дополнительным использованием необходимого документооборота в электронном виде.
New legal provisions on the introduction of electronic document management into the sphere of labor relations are being considered on the basis of amendments to the Labor Code of the Russian Federation introduced by Federal Law No. 377-FZ of November 22, 2021. The objective conditionality of these innovations by the active development of the digital economy and the expansion of the use of digital technologies in the activities of economic entities is emphasized. The emerging opportunities for interaction between the parties to labor relations - the employer and the employee with the additional use of the necessary document flow in electronic form are shown.
The possibility of introducing, as well as the objective application of a progressive scale of taxation on the territory of the Russian Federation
Authors: Арабаджийская Е.И. , Останков Д.А. 
Published: August 2022

Статья посвящена рассмотрению сущности прогрессивного налогообложения на доходы физических лиц и его отличительным особенностям, позволяющим отличать данную систему налогообложения от других. Актуальность изучения данного явления связана с появлением нововведений в нашем налоговом законодательстве и необходимостью изучения перспектив применения данных новшеств на практике. В работе изучены примеры реализации прогрессивной шкалы налогообложения в других странах, а также приводится теоретический анализ данного вида налогообложения, подробно описывающий как его положительные, так и отрицательные моменты.
The article is devoted to the consideration of the essence of progressive taxation on personal income and its distinctive features that make it possible to distinguish this taxation system from others. The relevance of studying this phenomenon is connected with the appearance of innovations in our tax legislation and the need to study the prospects of applying these innovations in practice. The paper examines examples of the implementation of the progressive scale of taxation in other countries, and also provides a theoretical analysis of this type of taxation, describing in detail both its positive and negative aspects.
Digitalization of legal education: challenges or opportunities
Authors: Дорохов Н.И. 
Published: August 2022

В статье рассматриваются состояние, актуальные проблемы и перспективы развития цифровых технологий в области современного юридического образования; обосновываются положения относительно трансформации профессиональной подготовки юристов в цифровую эпоху. Цель представленного исследования заключается в теоретико-методологическом осмыслении места и роли цифровизации, ее инструментария в системе юридической практики и современного юридического образования, выявление и обоснование возможных рисков и оптимальных путей их разрешения с учетом современных юридических реалий. Данный подход, с одной стороны, свидетельствует об очевидной актуальности и востребованности исследования заявленной темы; с другой стороны, требует весьма четких методологических подходов и методов исследования, в их числе – общефилософские (общемировоззренческие) подходы, общенаучные методы (приемы) и в определенной степени частнонаучные (специальные) методы. Основные результаты исследования указывают на комплексный характер цифровизации юриспруденции, включая систему юридического образования; обосновывают общие выводы и рекомендации по реализации потенциала цифровизации как основного тренда дня сегодняшнего.
The article discusses the state, current problems and prospects for the development of digital technologies in the field of modern legal education; substantiates the provisions regarding the transformation of the professional training of lawyers in the digital age. The purpose of the present study is to theoretically and methodologically understand the place and role of digitalization, its tools in the system of legal practice and modern legal education, to identify and justify possible risks and the best ways to resolve them, taking into account modern legal realities. This approach, on the one hand, indicates the obvious relevance and relevance of the study of the stated topic; on the other hand, it requires very clear methodological approaches and research methods, including general philosophical (worldview) approaches, general scientific methods (techniques) and, to a certain extent, particular scientific (special) methods. The main results of the study indicate the complex nature of the digitalization of jurisprudence, including the system of legal education; substantiate general conclusions and recommendations for realizing the potential of digitalization as the main trend of today.
The protein C deficiency and its effects on in-vitro fertilization outcome and recurrent pregnancy loss: a Syrian cohort study
Authors: Khoury Fadi , Deeb Haya , Jarouj Rana , Khoury Hanna , Alhalabi Nawras , Alhalabi Marwan 
Published: August 2022

Background: Protein C deficiency is a rare disease; it could be primary or secondary. Female patients with protein C deficiency may develop pregnancy-associated thrombosis. The clear association between the protein C deficiency and fertility or in-vitro fertilization (IVF) results has not been known yet. In our study, we aimed to determine the prevalence of protein C deficiency in Syrian infertile women and to assess the impact of protein C deficiency on abortion, recurrent IVF Failure, and IVF results.Methods: the electronic patients’ results were retrospectively screened. A total of 238 women, who had IVF cycles between January 2012 and December 2017 in a tertiary care hospital, met our including criteria.Results: the prevalence of protein C deficiency was 13.45%. There was a significant association between the protein C level and recurrent pregnancy loss (RPL). Furthermore, the protein C deficiency has an impact on the IVF results. Additionally, we did not find any association between protein C deficiency and age or number of previous IVF cycles.Conclusions: the protein C could be the hidden factor that affects IVF results. More research should be done to better understanding the role of protein C in infertility and IVF.
Efficacy of the Swede score in prediction of high-grade lesions of cervix
Authors: Chowdhury Lipika , Chowdhury Shahanara , Banu Nasreen , Sharmin Zenifar , Tabassum Masuma , Sultana Marjan , Alam S. K. Tasnuva 
Published: August 2022

Background: Cervical cancer is a preventable lesion that can be identified by stepwise screening methods. Visual inspection of the cervix with acetic acid, Lugol’s iodine, pap smear, and HPV are the primary screening methods. This study aims to evaluate the efficacy of the Swede score in predicting high-grade lesions of the cervix among patients attending a colposcopy clinic. Methods: This observational cross-sectional study was performed in a colposcopy clinic under the department of obstetrics and gynaecology at CMCH. All referral patients to the colposcopy clinic were the study population. Women aged between 25-65 years was the study subject. Results: Majority (47.5%) of the patient’s Swede score was 4 and 20.1of % of patients had scores of 5-6 and only 1.3% of patients had scores ≥7%. 63 (79%) patients had low grade/normal/ cervical intraepithelial lesion (CIN) 1, 16 (20%) patients had high grade/non-invasive cancer/CIN 2 and only 1 patient had high grade/suspected invasive cancer/CIN 3. A score of 6 had a specificity of 100% for CIN 2 with a sensitivity of 30% positive and negative predictive value (PPV=100%; NPV=90.9%). Lowering the score to 5 for predicting CIN 2 improved the sensitivity at the expense of specificity (sensitivity=60%; specificity=90%; PPV= 94%; NPV=46.2%).Conclusions: Swede scoring system is consistent and reproducible, has a simple structure, and thus contributes to preventing cervical cancer. Swede score of 6 or more has 100% specificity; this scoring method is a preferred method for the treatment of high-grade CIN.