bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prediction and Influential Factors of Violence in Male Schizophrenia Patients With Machine Learning Algorithms
Authors: Yu Tao , Zhang Xulai , Liu Xiuyan , Xu Chunyuan , Deng Chenchen 
Published: March 2022

BackgroundEarly to identify male schizophrenia patients with violence is important for the performance of targeted measures and closer monitoring, but it is difficult to use conventional risk factors. This study is aimed to employ machine learning (ML) algorithms combined with routine data to predict violent behavior among male schizophrenia patients. Moreover, the identified best model might be utilized to calculate the probability of an individual committing violence.MethodWe enrolled a total of 397 male schizophrenia patients and randomly stratified them into the training set and the testing set, in a 7:3 ratio. We used eight ML algorithms to develop the predictive models. The main variables as input features selected by the least absolute shrinkage and selection operator (LASSO) and logistic regression (LR) were integrated into prediction models for violence among male schizophrenia patients. In the training set, 10 × 10-fold cross-validation was conducted to adjust the parameters. In the testing set, we evaluated and compared the predictive performance of eight ML algorithms in terms of area under the curve (AUC) for the receiver operating characteristic curve.ResultOur results showed the prevalence of violence among male schizophrenia patients was 36.8%. The LASSO and LR identified main risk factors for violent behavior in patients with schizophrenia integrated into the predictive models, including lower education level [0.556 (0.378–0.816)], having cigarette smoking [2.121 (1.191–3.779)], higher positive syndrome [1.016 (1.002–1.031)] and higher social disability screening schedule (SDSS) [1.081 (1.026–1.139)]. The Neural Net (nnet) with an AUC of 0.6673 (0.5599–0.7748) had better prediction ability than that of other algorithms.ConclusionML algorithms are useful in early identifying male schizophrenia patients with violence and helping clinicians take preventive measures.
CAG Repeats Within the Non-pathological Range in the HTT Gene Influence Personality Traits in Patients With Subjective Cognitive Decline: A 13-Year Follow-Up Study
Authors: Moschini Valentina , Mazzeo Salvatore , Bagnoli Silvia , Padiglioni Sonia , Emiliani Filippo , Giacomucci Giulia , Morinelli Carmen , Ingannato Assunta , Freni Tommaso , Belloni Laura , Ferrari Camilla , Sorbi Sandro , Nacmias Benedetta , Bessi Valentina 
Published: March 2022

Objective:HTT is a gene containing a key region of CAG repeats. When expanded beyond 39 repeats, Huntington disease (HD) develops. HTT genes with &lt;35 repeats are not associated with HD. The biological function of CAG repeat expansion below the non-pathological threshold is not well understood. In fact higher number of repeats in HTT confer advantageous changes in brain structure and general intelligence, but several studies focused on establishing the association between CAG expansions and susceptibility to psychiatric disturbances and to other neurodegenerative disease than HD. We hypothesized that HTT CAG repeat length below the pathological threshold might influence mood and personality traits in a longitudinal sample of individuals with Subjective Cognitive Decline.MethodsWe included 54 patients with SCD. All patients underwent an extensive neuropsychological battery at baseline, APOE genotyping and analysis of HTT alleles. We used the Big Five Factors Questionnaire (BFFQ) and Hamilton Depression Rating Scale (HDRS), respectively, to assess personality traits of patients and depression at baseline. Patients who did not progress to Mild Cognitive Impairment (MCI) had at least 5-year follow-up time.ResultsIn the whole sample, CAG repeat number in the shorter HTT allele was inversely correlated with conscientiousness (Pearson = −0.364, p = 0.007). There was no correlation between HDRS and CAG repeats. During the follow-up, 14 patients [25.93% (95% C.I. = 14.24–37.61)] progressed to MCI (MCI+) and 40 [74.07% (95% C.I. = 62.39–85.76)] did not (MCI−). When we performed the same analysis in the MCI+ group we found that: CAG repeat length on the shorter allele was inversely correlated with energy (Pearson = 0.639, p = 0.014) and conscientiousness (Pearson = −0.695, p = 0.006). CAG repeat length on the longer allele was inversely correlated with conscientiousness (Pearson = −0.901, p &lt; 0.001) and directly correlated with emotional stability (Pearson = 0.639, p = 0.014). These associations were confirmed also by multivariate analysis. We found no correlations between BFFQ parameters and CAG repeats in the MCI− group.DiscussionPersonality traits and CAG repeat length in the intermediate range have been associated with progression of cognitive decline and neuropathological findings consistent with AD. We showed that CAG repeat lengths in the HTT gene within the non-pathological range influence personality traits.
“Post-lockdown Depression”: Adaptation Difficulties, Depressive Symptoms, and the Role of Positive Solitude When Returning to Routine After the Lifting of Nation-Wide COVID-19 Social Restrictions
Authors: Keisari Shoshi , Palgi Yuval , Ring Lia , Folkman Adi , Ben-David Boaz M. 
Published: March 2022

ObjectivesThe aim of the current study was to identify difficulties in adapting to normal life once COVID-19 lockdown has been lifted. Israel was used as a case study, as COVID-19 social restrictions, including a nation-wide lockdown, were lifted almost completely by mid-April 2021, following a large-scale vaccination operation.MethodsA sample of 293 mid-age and older Israeli adults (M age = 61.6 ± 12.8, range 40–85 years old) reported on return-to-routine adaptation difficulties (on a novel index), depression, positive solitude, and several demographic factors.ResultsOf the participants, 40.4% met the criteria of (at least) mild depressive symptoms. Higher levels of adaptation difficulties were related to higher ratios of clinical depressive symptoms. This link was moderated by positive solitude. Namely, the association between return-to-routine adaptation difficulties and depression was mainly indicated for individuals with low positive solitude.ConclusionsThe current findings are of special interest to public welfare, as adaptation difficulties were associated with higher chance for clinical depressive symptoms, while positive solitude was found to be as an efficient moderator during this period. The large proportion of depressive symptoms that persist despite lifting of social restrictions should be taken into consideration by policy makers when designing return-to-routine plans.
Concrete Experiences and Support Needs Regarding the Euthanasia Practice in Adults With Psychiatric Conditions: A Qualitative Interview Study Among Healthcare Professionals and Volunteers in Belgium
Authors: Verhofstadt Monica , Audenaert Kurt , Mortier Freddy , Deliens Luc , Liégeois Axel , Pardon Koen , Chambaere Kenneth 
Published: March 2022

ObjectiveAlthough euthanasia in the context of adult psychiatry is legalized in Belgium, it poses major ethical and clinical challenges for the health care professionals and volunteers involved. This study aimed to address these members' concrete experiences and support needs.MethodsA qualitative semi-structured interview study was conducted with 16 physicians and 14 other health care professionals and volunteers, with at least one concrete experience with euthanasia requests and procedures concerning adults with psychiatric conditions.FindingsConcrete experiences concerned the following 8 domains: (1) the impact of euthanasia on the clinical trajectory and (2) on the therapeutic relationship, (3) internal and (4) external collaborative partnerships, (5) patients' social inner circle (non-)involvement, (6) the use of recently published guidelines and, (7) the first criminal trials on this topic, and (8) the act of euthanasia. The following 8 main support needs emerged; (1) protocols addressing specific sub-populations and pathologies, (2) protocols specifically drawn up for non-medics, (3) guidance on how to adequately implement the two-track approach, (4) (after)care for patients, (5) (after)care for the health care team, (6) guidance on the patient's social inner circle involvement, (7) enhanced education measures, and (8) enhanced financial measures, including incentives for holistic, palliative care approaches.ConclusionThe health care professionals and volunteers reported many positive and negative experiences in dealing with euthanasia requests in adult psychiatry. They reported several support needs across the extensive euthanasia trajectory, pertaining to concrete management of thorny issues that guidelines do not (yet) touch on. Important implications of our study relate to tackling these existing issues, and to paying sufficient attention to the impact of a euthanasia trajectory on all actors, including the patients and their social inner circle, involved.
emteqPRO—Fully Integrated Biometric Sensing Array for Non-Invasive Biomedical Research in Virtual Reality
Authors: Gnacek Michal , Broulidakis John , Mavridou Ifigeneia , Fatoorechi Mohsen , Seiss Ellen , Kostoulas Theodoros , Balaguer-Ballester Emili , Kiprijanovska Ivana , Rosten Claire , Nduka Charles 
Published: March 2022

Virtual Reality (VR) enables the simulation of ecologically validated scenarios, which are ideal for studying behaviour in controllable conditions. Physiological measures captured in these studies provide a deeper insight into how an individual responds to a given scenario. However, the combination of the various biosensing devices presents several challenges, such as efficient time synchronisation between multiple devices, replication between participants and settings, as well as managing cumbersome setups. Additionally, important salient facial information is typically covered by the VR headset, requiring a different approach to facial muscle measurement. These challenges can restrict the use of these devices in laboratory settings. This paper describes a solution to this problem. More specifically, we introduce the emteqPRO system which provides an all-in-one solution for the collection of physiological data through a multi-sensor array built into the VR headset. EmteqPRO is a ready to use, flexible sensor platform enabling convenient, heterogenous, and multimodal emotional research in VR. It enables the capture of facial muscle activations, heart rate features, skin impedance, and movement data—important factors for the study of emotion and behaviour. The platform provides researchers with the ability to monitor data from users in real-time, in co-located and remote set-ups, and to detect activations in physiology that are linked to arousal and valence changes. The SDK (Software Development Kit), developed specifically for the Unity game engine enables easy integration of the emteqPRO features into VR environments.Code available at: (https://github.com/emteqlabs/emteqvr-unity/releases)
Psychological Distress in the Galapagos Islands During the COVID-19 Pandemic
Authors: Paz Clara , Abiuso Trinidad , Adana-Díaz Lila , Rodríguez-Lorenzana Alberto , Jaramillo-Vivanco Tatiana , Ortiz-Prado Esteban , Páez Monge Ignacia , Mascialino Guido 
Published: March 2022

Objectives: to explore the emotional impact of the COVID-19 pandemic in the Galapagos Islands.Methods: an online survey of 369 participants, conducted on October of 2020, was used to assess levels of depression, anxiety, and stress, as well as specific behavioral and emotional reactions to the pandemic.Results: the prevalence of anxiety was 4% and depression 3.65%. Perceived stress level was higher, with 52% of the sample reporting moderate amounts. Women had higher levels of depression and perceived stress. Financial distress, interpersonal conflicts, feelings of isolation and fear of contagion of COVID-19 were all associated with higher levels of anxiety, depression, and stress.Conclusion: prevalence of anxiety and depression is lower in the Galápagos Islands during the pandemic compared to other regions, while stress levels are more significant and may warrant intervention. Despite being low, anxiety and depression were associated with potentially problematic behaviors and emotional reactions.
20 Years of Botulinum Therapy of Dystonia in the Republic of Belarus: Results of Work
Authors: Лихачев С.А. , Чернуха Т.Н. , Рушкевич Ю.Н. , Веевник Е.В. , Глеб О.В. , Белоголовая Е.А. , Забродец Г.В. , Черненко Н.И. , Зобнина Г.В. , Мельник В.Ф. 
Published: March 2022

В статье подведены итоги 20-летней работы по ботулинотерапии мышечных дистоний в Республике Беларусь. Представлены этапы организации медицинской помощи пациентам с мышечными дистониями. В Беларуси создан реестр пациентов, на начало 2020 г. насчитывается 1390 пациентов с дистониями и 219 – с гемифациальным спазмом. В статье рассмотрены данные по распределению пациентов по формам дистонии, приведены данные по областям республики. Проанализированы результаты долгосрочного лечения пациентов с мышечными дистониями инъекциями ботулотоксина у пациентов со спастической кривошеей, блефароспазмом, камптокормией, оромандибулярной дистонией, писчим спазмом, ларингеальной дистонией, доказана эффективность и безопасность повторных инъекций ботулотоксина типа А для лечения дистоний. Внедрение системы организации медицинской помощи по лечению пациентов с мышечными дистониями в республике привело к снижению доли и тяжести инвалидности среди пациентов с дистоническими гиперкинезами.
In the article, we summed up the results of botulinum therapy of dystonia during 20 years in the Republic of Belarus. We presented the stages of organizing medical care for patients with dystonia. A register of patients was created in Belarus at the beginning of 2020; there are 1390 patients with dystonia and 219 patients with hemifacial spasm. In the article, we examined information on the distribution of patients by the forms of dystonia, the data on the regions of the republic are presented. We analyzed the results of long-term treatment of patients with dystonia that used botulinum toxin injections, including spasmodic torticollis, blepharospasm, camptocormia, oromandibular dystonia, writer’s cramp, laryngeal dystonia; and we proved the efficacy and safety of repeated injections of botulinum toxin type A for the treatment of dystonia. The introduction of the medical care organization system for the treatment of patients with dystonia in the republic led to the decrease in the proportion and severity of disability among patients with dystonic hyperkinesis.
Clinical and Morphological Signs of Abnormalities of Tricuspid Valve Complex
Authors: Трисветова Е.Л. , Юдина О.А. 
Published: March 2022

Аномалии трехстворчатого клапана встречаются реже по сравнению с отклонениями развития митрального клапана. Единичные публикации освещают морфологические и клинические особенности, обусловливающие незначительные внутрисердечные гемодинамические нарушения или тяжелые изменения в виде регургитации или стеноза отверстия трехстворчатого клапана, вызывающие гипертрофию либо дилатацию правого предсердия и желудочка и хроническую сердечную недостаточность. Особенности эмбрионального развития манифестируют в разном возрастном периоде, с клиническими признаками, подобными проявлениям врожденных пороков сердца. Диагностика аномалий трехстворчатого клапана проводится методами визуализации структур сердца или является «случайной» находкой при оперативном лечении либо при аутопсии.
Anomaliesofthetricuspidvalvearelesscommonifcomparedwithabnormalitiesinthedevelopment of the mitral valve. Single publications highlight the morphological and clinical features that cause minor intracardiac hemodynamic disorders or severe changes in the form of regurgitation or stenosis of the tricuspid valve opening, causing hypertrophy or dilatation of the right atrium and ventricle, and chronic heart failure. The features of embryonic development manifest in different age periods, with clinical signs similar to manifestations of congenital heart defects. Diagnostics of anomalies of the tricuspid valve is carried out with the methods of visualization of the structures of the heart or it can be a "random" finding during surgical treatment or autopsy.
anomalies of the tricuspid valve, morphological signs, clinical signs, complications
RESPON TANGGAP DARURAT GEMPA MAMUJU DI DESA TADUI
Authors: Herlina Herlina , Yosephi Valensa 
Published: March 2022

Gempa bumi adalah getaran atau guncangan yang terjadi di permukaan bumi yang disebabkan oleh tumbukan antar lempeng bumi, patahan aktif, akitivitas gunung api atau runtuhan batuan. Gempa tektonik pada 15 Januari 2021 terjadi dengan kekuatan 6,2 SR yang dirasakan di hampir seluruh Provinsi Sulawesi Barat. Sebagai pendidik yang melaksanakan Tri Dharma Perguruan Tinggi dan karena kepedulian kepada sesama, dibentuklah suatu tim sebagai tim respon cepat. Tujuannya yaitu untuk meringankan beban pengungsi dan memenuhi kebutuhan pokok pasca gempa serta memberikan pelayanan kesehatan pasca bencana. Kegiatan ini memiliki sasaran 100 KK di desa Tadui, Kecamatan Mamuju, Kabupaten Mamuju yang dilakukan selama 3 hari dari tanggal 17-19 Januari 2021. Tahapan kegiatan pengabdian kepada masyarakat, yaitu pengumpulan donasi, persiapan logistik obat dan sembako, pengemasan sembako, perjalanan menuju titik lokasi pengabdian, pemeriksaan kesehatan, dan pembagian sembako. Di Desa Tadui, mayoritas kerusakan yang terjadi adalah kerusakan ringan karena Desa Tadui termasuk desa miskin yang rumahnya terbuat dari kayu sehingga tidak terjadi kerusakan yang parah. Tim melakukan pemeriksaan kesehatan dan pembagian sembako di 4 posko besar dan tercatat lebih dari 100 KK yang dilayani di desa ini. Rata-rata penyakit yang diderita oleh masyarakat desa Tadui adalah penyakit infeksi saluran pernapasan akut (ISPA), mialgia, demam, diare berdarah, dispepsia, cefalgia, diare akut, dan vulnus laseratum atau luka robek. Setelah pemeriksaan, masyarakat kemudian diberikan sembako untuk mereka bawa pulang ke tempat pengungsiannya.
Nuevo índice espectro-temporal para la detección de pérdida forestal en áreas de bosque tropical. Caso de estudio Amazonia colombiana
Authors: Hurtado Abril José Leonardo , Lizarazo Ivan 
Published: March 2022

En la actualidad, una gran problemática a nivel global es la acelerada tasa de pérdida de bosques y los efectos que repercuten en la delicada estabilidad del medio ambiente. Colombia posee una de las mayores extensiones de bosque natural en el planeta, al igual que una alta tasa de deforestación. Existen diversas herramientas y metodologías para la detección de pérdida de bosque teniendo como insumo las imágenes de satélite y productos derivados de ellos. Sin embargo, al momento de iniciar la investigación, la identificación de pérdida de bosque se realizaba usando dos o más índices o transformaciones espectrales al igual que la edición manual, lo que conlleva a mayor tiempo y propagación de errores. El presente estudio tiene como objetivo la generación de un índice espectral y temporal con la capacidad de extraer áreas deforestadas en un rango de tiempo y zona de interés definida por el usuario por medio de imágenes desatélite Landsat. Para ello, se desarrolla una metodología basada en el análisis de series de tiempo usando la herramienta LandTrendr para identificar los rangos espectrales que permiten detectar perturbación de bosque y posteriormente proponer una ecuación para el cálculo de un indicador de perturbación por deforestación. La utilidad del índice propuesto se prueba en algunas zonas de la Amazonia colombiana en las cuales existen datos de deforestación oficiales para el periodo 2000 a 2017. Los resultados de las pruebas muestran que el índice propuesto permite obtener una exactitud temática superior al 80%. El índiceespectral no solo identifica la pérdida de bosque sino su posible regeneración lo que permitiría obtener las cifras de diversos cambios en el bosque. Finalmente, el índice logra identificar las zonas de perturbación en el bosque con buenos resultados en su exactitud temática.
La cartografía de suelos y su aporte a la ordenación ambiental del territorio: Cuenca Superior del Arroyo Tandileofú (Tandil, Argentina)
Authors: Nuñez Mariana Verónica , Ulberich Ana Cristina , Miranda del Fresno María Carolina , Cisneros Basualdo Nicolás Eloy , Galecio María Florencia 
Published: March 2022

Los estudios de Ordenación Ambiental del Territorio (OAT) constituyen un modelo de zonificación y a la vez una herramienta que demanda el proceso de ordenación territorial para articular políticas y acciones de planeamiento compatibles con las expectativas del desarrollo sustentable. Con el fin de delimitar y describir “sistemas ambientales” de la OAT de la Cuenca Superior del Arroyo Tandileofú (CSAT) se siguió una secuencia metodológica, apoyada en cartografía de suelos, mediante la cual se elaboraron mapas temáticos intermedios y un mapa de OAT que integra los anteriores. La secuencia comenzó con la Zonificación Morfológica Superficial, a lo que le sucedió la Zonificación Edáfica derivando en la Zonificación Morfoedáfica; a esta última, se la correlacionó con la vegetación, resultando el mapa de Zonificación Morfo-FitoEdáfica o Zonificación Ecológica; luego, se incorporó el Uso Actual
de las Tierras (UAT), lo que permitió analizar las relaciones sociedad naturaleza en la CSAT e identificar potenciales problemas ambientales producto de esta relación y elaborar el mapa de OAT de la CSAT. Los resultados obtenidos posibilitaron interpretar la heterogeneidad interna de los sistemas ecológico-paisajísticos y obtener 7 subsistemas ecológicos; el estudio y mapeo del UAT demostró que las tierras están principalmente ocupadas por actividades agropecuarias mixtas (46,4%), agrícolas (31,3%) y tamberas (12,4%); la OAT de la Cuenca permitió obtener 16 tipos de unidades cartográficas que describen entidades territoriales con restricciones y potencialidades ecológicas de cada paisaje/sitio, con la estructura espacial y funciones de tipos y formas del UAT. A modo de conclusión, es posible inferir y correlacionar la información topográfico-paisajística analizando las cartas de suelos y las descripciones de cada sistema y subsistema representados en ellas; la metodología propuesta enfatiza y pone en valor el uso de los recursos y productos que surgen de la Ciencia Cartográfica en las tareas de gestión y planificación territorial.