bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Promising Role of Microbiome Therapy on Biomarkers of Inflammation and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative Review
Authors: Paul Pradipta , Kaul Ridhima , Abdellatif Basma , Arabi Maryam , Upadhyay Rohit , Saliba Reya , Sebah Majda , Chaari Ali 
Published: May 2022

BackgroundOne in 10 adults suffer from type 2 diabetes (T2D). The role of the gut microbiome, its homeostasis, and dysbiosis has been investigated with success in the pathogenesis as well as treatment of T2D. There is an increasing volume of literature reporting interventions of pro-, pre-, and synbiotics on T2D patients.MethodsStudies investigating the effect of pro-, pre-, and synbiotics on biomarkers of inflammation and oxidative stress in T2D populations were extracted from databases such as PubMed, Scopus, Web of Science, Embase, and Cochrane from inception to January 2022.ResultsFrom an initial screening of 5,984 hits, 47 clinical studies were included. Both statistically significant and non-significant results have been compiled, analyzed, and discussed. We have found various promising pro-, pre-, and synbiotic formulations. Of these, multistrain/multispecies probiotics are found to be more effective than monostrain interventions. Additionally, our findings show resistant dextrin to be the most promising prebiotic, followed closely by inulin and oligosaccharides. Finally, we report that synbiotics have shown excellent effect on markers of oxidative stress and antioxidant enzymes. We further discuss the role of metabolites in the resulting effects in biomarkers and ultimately pathogenesis of T2D, bring attention toward the ability of such nutraceuticals to have significant role in COVID-19 therapy, and finally discuss few ongoing clinical trials and prospects.ConclusionCurrent literature of pro-, pre- and synbiotic administration for T2D therapy is promising and shows many significant results with respect to most markers of inflammation and oxidative stress.
“Sandwich Therapy”—Immunotherapy Plus Concurrent Chemoradiotherapy for Advanced Esophagogastric Junction Carcinoma: Report of Two Cases and Literature Review
Authors: Wu Lei , Liu Juan , Liang Long , Mao Mian , Li Xiangpan , Li Tao , Lang Jinyi , Wang Qifeng 
Published: May 2022

IntroductionEsophagogastric junction (EGJ) carcinomas develop in the transition zone between the esophagus and stomach. The incidence of EGJ carcinoma has steadily increased over the past few decades. Most patients are first diagnosed at an advanced stage, which renders them ineligible for surgery. Current methods for the treatment of advanced EGJ carcinoma include surgery, chemotherapy, local palliative therapy, and supportive care; however, none of these treatment methods has provided satisfactory therapeutic effects when used alone.Case ReportWe report two cases of patients with EGJ carcinoma who were sequentially treated with immunotherapy plus induction chemotherapy, followed by immunotherapy plus concurrent chemoradiotherapy and maintenance immunotherapy. Both patients achieved extended overall survival times with good quality of life with this new therapeutic approach.ConclusionImmunotherapy plus chemoradiotherapy may therefore be a reasonable option for treatment of selected EGJ carcinoma patients. However, well-designed trials for the acquisition of additional evidence are required to validate the findings in this study.
Factors Affecting the Exercise Capacity in Pediatric Primary Hypertension
Authors: Zhang Hui , Chen Yeshi , Zheng Tong , Zhang Mingming , Li Xiaohui , Shi Lin 
Published: May 2022

PurposeExercise training is crucial to the early intervention of pediatric primary hypertension (PHT). However, much less is known about exercise capacity in this disease. This work investigated the exercise capacity in pediatric PHT and analyzed the factors affecting exercise capacity.MethodsThe study enrolled children with PHT at the Children's Hospital Capital Institute of Pediatrics between July 2017 and July 2020. The Bruce protocol of the treadmill exercise test (TET) was used to assess exercise capacity. Multivariate ordinal logistic regression and generalized linear models were used to analyze factors affecting exercise capacity.ResultsOf 190 patients, 146 (76.8%) were male, and the median age was 13 (11, 14). Most children accomplished TET and achieved the submaximal heart rates (189 [99.5%]). Children with lower resting diastolic blood pressure (DBP) and 24 h average diastolic blood pressure (ADBP) could achieve a TET stage of 6 or more, whereas children with higher DBP and ADBP could only achieve a TET stage of 3 (P all &lt; 0.05). Children with lower DBP and 24 h ADBP were also associated with greater metabolic equivalents (METs; r = −0.237, r = −0.179, P all &lt; 0.05). The completion of TET stages was negatively associated with female (OR = 0.163), younger age (OR = 1.198), greater body mass index (BMI, OR = 0.921), and higher 24 h ADBP (OR = 0.952, P all &lt; 0.05). In addition, METs were negatively associated with female (β = −1.909), younger age (β = 0.282), greater BMI (β = −0.134), and higher 24 h ADBP (β = −0.063, P all &lt; 0.05).ConclusionsExercise capacity was impaired among pediatric PHT patients. Female gender, younger age, greater BMI, and higher 24 h ADBP are independently associated with the exercise capacity in pediatric PHT. These findings may help developing scientific exercise prescriptions for pediatric PHT.
Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2
Authors: Ren Hong-can , Sun Jian-guo , A Ji-ye , Gu Sheng-hua , Shi Jian , Shao Feng , Ai Hua , Zhang Jing-wei , Peng Ying , Yan Bei , Huang Qing , Liu Lin-sheng , Sai Yang , Wang Guang-ji , Yang Cheng-guang 
Published: May 2022

Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration. The aim of this work was to 1) simultaneously characterise the pharmacokinetics of Rh2 and PPD following intravenous and oral Rh2 administration, 2) develop and validate a mechanism-based pharmacokinetic model to describe the deglycosylation kinetics and 3) predict the percentage of Rh2 entering the systemic circulation in PPD form.Methods: Plasma samples were collected from rats after the I.V. or P.O. administration of Rh2. The plasma Rh2 and PPD concentrations were determined using HPLC-MS. The transformation from Rh2 to PPD, its absorption, and elimination were integrated into the mechanism based pharmacokinetic model to describe the pharmacokinetics of Rh2 and PPD simultaneously at 10 mg/kg. The concentration data collected following a 20 mg/kg dose of Rh2 was used for model validation.Results: Following Rh2 administration, PPD exhibited high exposure and atypical double peaks. The model described the abnormal kinetics well and was further validated using external data. A total of 11% of the administered Rh2 was predicted to be transformed into PPD and enter the systemic circulation after I.V. administration, and a total of 20% of Rh2 was predicted to be absorbed into the systemic circulation in PPD form after P.O. administration of Rh2.Conclusion: The developed model provides a useful tool to quantitatively study the deglycosylation kinetics of Rh2 and thus, provides a valuable resource for future pharmacokinetic studies of glycosides with similar deglycosylation metabolism.
Cannabis for Medical Use: Analysis of Recent Clinical Trials in View of Current Legislation
Authors: Baratta F. , Pignata I. , Ravetto Enri L. , Brusa P. 
Published: May 2022

Cannabis has long been regarded as a recreational substance in the Western world. The recent marketing authorization of some medicinal products of industrial origin and the introduction onto the market of inflorescences for medical use mean that medical doctors can now prescribe Cannabis-based medicines in those countries which allow it. Nevertheless, there is still considerable controversy on this topic in the scientific community. In particular, this controversy concerns: the plant species to be used; the pathologies that can be treated and consequently the efficacy and safety of use; the routes of administration; the methods of preparation; the type and dosage of cannabinoids to be used; and, the active molecules of interest. As such, although medical Cannabis has been historically used, the results of currently completed and internationally published studies are inconclusive and often discordant. In light of these considerations, the aim of this work is to analyse the current legislation in countries that allow the use of medical Cannabis, in relation to the impact that this legislation has had on clinical trials. First of all, a literature search has been performed (PubMed and SciFinder) on clinical trials which involved the administration of Cannabis for medical use over the last 3 years. Of the numerous studies extrapolated from the literature, only about 43 reported data on clinical trials on medical Cannabis, with these mainly being performed in Australia, Brazil, Canada, Denmark, Germany, Israel, Netherlands, Switzerland, the United Kingdom and the United States of America. Once the reference countries were identified, an evaluation of the legislation in relation to Cannabis for medical use in each was carried out via the consultation of the pertinent scientific literature, but also of official government documentation and that of local regulatory authorities. This analysis provided us with an overview of the different legislation in these countries and, consequently, allowed us to analyse, with greater awareness, the results of the clinical trials published in the last 3 years in order to obtain general interest indications in the prosecution of scientific research in this area.
Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity
Authors: Huang Si , Xiao Jingxian , Wu Junyong , Liu Jiayi , Feng Xueping , Yang Chengdong , Xiang Daxiong , Luo Shilin 
Published: May 2022

The antiparasitic drug nitazoxanide (NTZ) has received considerable attention for its potential in cancer therapy. In this study, we demonstrate that tizoxanide (TIZ), an active metabolite of NTZ, exhibits antiglioma activity in vitro and in vivo by inducing G2/M cell cycle arrest and apoptosis. In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC50 values of 1.10, 2.31, and 0.73 µM, respectively. Treatment with TIZ (1 and 10 µM) also dose-dependently inhibited the colony formation of these GBM cells and accumulated ROS damage in the nucleus. In silico target fishing combined with network pharmacological disease spectrum analyses of GBM revealed that cycle-dependent kinase 1 (CDK1) is the most compatible target for TIZ and molecular docking by Molecule Operating Environment (MOE) software confirmed it. Mechanistically, TIZ inhibited the phosphorylation of CDK1 at Thr161 and decreased the activity of the CDK1/cyclin B1 complex, arresting the cell cycle at the G2/M phase. TIZ may induce apoptosis via the ROS-mediated apoptotic pathway. In vivo, TIZ suppressed the growth of established subcutaneous and intracranial orthotopic xenograft models of GBM without causing obvious side effects and prolonged the survival of nude mice bearing glioma. Taken together, our results demonstrated that TIZ might be a promising chemotherapy drug in the treatment of GBM.
The Effect of Whole-Body Traditional and Functional Resistance Training on CAVI and Its Association With Muscular Fitness in Untrained Young Men
Authors: Zuo Chongwen , Bo Shumin , Li Qing , Zhang Li 
Published: May 2022

Background: Resistance training-induced changes in the muscle function is essential for the health promotion of the young and older, but the discrepancies of the effect of resistance training on arterial stiffness leads to the divergence regarding to the effect of resistance training on cardiovascular health. What confuses our understanding in this field may be the following factors: external load (higher intensity vs. lighter intensity), participants’ cardiovascular health, and arterial stiffness assessment measurement. The purpose of the present study was to investigate the effects of the whole-body traditional high-intensity vs. functional low-intensity resistance training protocol on systemic arterial stiffness, and their association with muscular fitness components in untrained young men.Methods: In this randomized controlled trial, twenty-nine untrained young men (mean age about 22.5 years old) were randomized into a 6-weeks (three sessions per week) supervised whole-body traditional high-intensity resistance group (TRT, n = 15) consisting of 4–5 sets of 12 repetitions (70%1RM, lower-repetitions) or a whole-body functional low-intensity resistance group (FRT, n = 14) with 4–5 sets of 20 repetitions (40%1RM, higher-repetitions) to volitional failure. The systemic arterial stiffness (cardio-ankle vascular index, CAVI) and muscular fitness components were assessed before and after the 6-weeks training program.Results: There was a significant decrease (pre-post) for CAVI only in FRT group (p &lt; 0.05), but no significant difference was observed between two groups. In addition, the TRT and FRT groups showed equally significantly increased in maximal strength, muscular endurance and power (within group: both p &lt; 0.01); however, the independent t test exhibited that the difference between two groups in terms of change in maximal strength, muscular endurance and power were no significant (p &gt; 0.05). Furthermore, the reduction in CAVI was negatively correlated with the increase in 1RM of bench press for all participants (r = −0.490, p &lt; 0.01).Conclusion:Using present criterion-standard assessments measurements demonstrates that CAVI was significantly reduced after 6-weeks functional resistance training with beneficial effect on muscular fitness. Negative and significant association between CAVI and 1RM bench press indicated the cardiovascular health may be involved in the regulation of resistance training.
Referral for Intensive Home Treatment or Psychiatric Inpatient Care? A Retrospective, Observational Comparison of Patient and Process Characteristics
Authors: van Asperen G. C. Roselie , Wierdsma André I. , de Winter Remco F. P. , Mulder Cornelis Lambert 
Published: May 2022

IntroductionIntensive home treatment (IHT) is intended to prevent the (mostly voluntary) admission of mentally ill patients by providing intensive care in their domestic environment. It requires approaches to referral that ensure the delivery of the best possible acute care. Indications for referral may be improved by greater understanding of the clinical profiles of patients referred for IHT and of those referred for inpatient care. As such understanding may also further the development of IHT and innovations within it, we compared the patient and process characteristics associated with IHT referral for those associated with inpatient care.MethodsThis retrospective, observational, explorative study was conducted from 2016 to 2019. Patients aged 18 years and older were assessed by the emergency psychiatric outreach services in the greater Rotterdam area (Netherlands). Anonymized data were used to compare patient and process characteristics between patients referred for IHT and those admitted voluntarily. Patient characteristics included gender, age, cultural background, living situation and main diagnosis. Additional the case mix was measured using the Severity of Psychiatric Illness (SPI) scale. Process characteristics included psychiatric history, the total number of contacts with the emergency psychiatric outreach services, assessments during office hours, place of assessment, referrer, and the reason for referral. Using multiple logistic regression analysis, the patient and process characteristics associated with IHT referral were compared with those associated with voluntary admission.ResultsThe emergency psychiatric outreach services undertook 12,470 assessments: 655 were referred for HT and 2,875 for voluntary admission. Patient characteristics: referral for IHT rather than voluntary admission was associated with higher motivation for treatment and better family involvement. Process characteristics: referral for IHT rather than voluntary admission was associated with assessment by the crisis services within office hours, no mental health treatment at the time of referral, and referral by a family doctor.DiscussionIHT in a specific Dutch setting seems to function as an intensive crisis intervention for a subgroup of patients who are motivated for treatment, have social support, and are not in outpatient treatment. The patient and process characteristics of patients referred for IHT should now be studied in more detail, especially, for having more social support, the role of the family members involved.
Recurrence Quantification Analysis of Ankle Kinematics During Gait in Individuals With Chronic Ankle Instability
Authors: Yen Sheng-Che , Qian Shaodi , Folmar Eric , Hasson Christopher J. , Chou Chun-An 
Published: May 2022

PurposeAn investigation of the ankle dynamics in a motor task may generate insights into the etiology of chronic ankle instability (CAI). This study presents a novel application of recurrence quantification analysis (RQA) to examine the ankle dynamics during walking. We hypothesized that CAI is associated with changes in the ankle dynamics as assessed by measures of determinism and laminarity using RQA.MethodsWe recorded and analyzed the ankle position trajectories in the frontal and sagittal planes from 12 participants with CAI and 12 healthy controls during treadmill walking. We used time-delay embedding to reconstruct the position trajectories to a phase space that represents the states of the ankle dynamics. Based on the phase space trajectory, a recurrence plot was constructed and two RQA variables, the percent determinism (%DET) and the percent laminarity (%LAM), were derived from the recurrence plot to quantify the ankle dynamics.ResultsIn the frontal plane, the %LAM in the CAI group was significantly lower than that in the control group (p &lt; 0.05. effect size = 0.86). This indicated that the ankle dynamics in individuals with CAI is less likely to remain in the same state. No significant results were found in the %DET or in the sagittal plane.ConclusionA lower frontal-plane %LAM may reflect more frequent switching between different patterns of neuromuscular control states due to the instabilities associated with CAI. With further study and development, %LAM may have the potential to become a useful biomarker for CAI.
Turbulent Heat Fluxes in a Mediterranean Eddy Quantified Using Seismic and Hydrographic Observations
Authors: Xiao Wuxin , Meng Zhou 
Published: May 2022

Mediterranean eddies (meddies) play an essential role in transferring heat, salinity and momentum into the Atlantic Ocean. The rate of heat (and salt) flux from the meddy and its ultimate lifetime are key proxies to understanding how meddies impact the redistribution of heat and salt in the ocean system. A Mediterranean eddy was observed in the Gulf of Caidz in 2007 using seismic and hydrographic data. The spatial distribution of turbulent dissipation rates around the meddy is estimated from the seismically derived internal wave spectra subrange using fine-scale parameterization. Turbulent dissipated rates are lowest (10−11 W/kg) within the core of the meddy but rise by nearly two orders of magnitude at the upper and lower boundaries, where signs of double diffusive convection are observed. Along the left flank of the meddy, thermohaline intrusions and interleaving of water masses are found in inverted temperature and salinity profiles, transporting heat laterally from the warm core to the Atlantic water with a flux of around 470 Wm−2. The meddy presented in this study is shown to decay in 2 years, primarily due to the heat loss associated with thermohaline intrusions. For the first time, heat fluxes around the meddy and its lifetime are quantified using seismic oceanography data, and the methods proposed here can be applied to more seismic datasets in the global oceans.
Influence of Foam Morphology on Flow and Heat Transport in a Random Packed Bed with Metallic Foam Pellets—An Investigation Using CFD
Authors: George Ginu R. , Bockelmann Marina , Schmalhorst Leonhard , Beton Didier , Gerstle Alexandra , Lindermeir Andreas , Wehinger Gregor D. 
Published: May 2022

Open-cell metallic foams used as catalyst supports exhibit excellent transport properties. In this work, a unique application of metallic foam, as pelletized catalyst in a packed bed reactor, is examined. By using a wall-segment Computational Fluid Dynamics (CFD) setup, parametric analyses are carried out to investigate the influence of foam morphologies (cell size ϕ=0.45–3 mm and porosity ε=0.55–0.95) and intrinsic conductivity on flow and heat transport characteristics in a slender packed bed (N=D/dp=6.78) made of cylindrical metallic foam pellets. The transport processes have been modeled using an extended version of conventional particle-resolved CFD, i.e., flow and energy in inter-particle spaces are fully resolved, whereas the porous-media model is used for the effective transport processes inside highly-porous foam pellets. Simulation inputs include the processing parameters relevant to Steam Methane Reforming (SMR), analyzed for low (Rep~100) and high (Rep~5000) flow regimes. The effect of foam morphologies on packed beds has shown that the desired requirements contradict each other, i.e., an increase in cell size and porosity favors the reduction in pressure drop, but, it reduces the heat transfer efficiency. A design study is also conducted to find the optimum foam morphology of a cylindrical foam pellet at a higher Rep~5000, which yields ϕ = 0.45, ε = 0.8. Suitable correlations to predict the friction factor and the overall heat transfer coefficient in a foam-packed bed have been presented, which consider the effect of different foam morphologies over a range of particle Reynolds number, 100≤Rep≤5000.
Le préfinancement du CICE et ses effets sur l’emploi : une évaluation ex post
Authors: Ben Hassine Haithem , Mathieu Claude 
Published: May 2022

CICE pre-Financing and Employment Effects : an ex post Evaluation.
The ex post evaluation presented here endeavours to measure the potential effects of the CICE pre-financing mechanism on preserving jobs due to fewer company failures in 2013 and 2014. The econometric analysis is backed by exhaustive data from INSEE and the use of propensity score matching methods (Kernel, five nearest neighbours, and Caliper). The results indicate that the pre-financed firms could have destroyed around 2,500 jobs (the effects range from approximately 900 to 4,000), if all else being equal, they had not received pre-financing. This effect only applies to firms with between 10 and 100 employees and only for 2013. Thus, the results of this study do not showa significant effect for very small firms (between 2 and 9 employees) or for firmswith more than 100 employees. The positive effect of pre-financing on safeguarding jobs in 2013 can be regarded as the upper end of the job preservation range, as a failed company may be forced out of the market.
Synthesis of phosphazene methacrylate oligomers and their use for modification of dental composite materials
Authors: BILICHENKO YU. V. , SON VU XUAN , THUAN PHAM VAN , SIROTIN I. S. , KIREEV V. V. , CHUEV V. P. , KLYUKIN B. V. , POSOKHOVA V. F. 
Published: May 2022

The reaction of epoxyphosphazenes with methacrylic acid was used to synthesize methacrylate-containing phosphazene oligomers (MPO) used to modify dental restorative materials.The introduction of 1015 wt.% MPO into the base bis-methacrylate binder composition can significantly increase the adhesion of modified cured compositions to tooth tissues and metals, as well as improve water resistance while maintaining the required strength indicators and other physicochemical characteristics required by GOST.