bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency of cold atmospheric plasma, cleaning powders and their combination for biofilm removal on two different titanium implant surfaces
Authors: Kamionka Julia , Matthes Rutger , Holtfreter Birte , Pink Christiane , Schlüter Rabea , von Woedtke Thomas , Kocher Thomas , Jablonowski Lukasz 
Published: January 2022

Abstract

Objectives
Biofilm removal is the decisive factor for the control of peri-implantitis. Cold atmospheric pressure plasma (CAP) can become an effective aid due to its ability to destroy and to inactivate bacterial biofilm residues. This study evaluated the cleaning efficiency of CAP, and air-polishing with glycine (APG) or erythritol (APE) containing powders alone or in combination with CAP (APG + CAP, APE + CAP) on sandblasted/acid etched, and anodised titanium implant surface.

Materials and methods
On respective titanium discs, a 7-day ex vivo human biofilm was grown. Afterwards, the samples were treated with CAP, APG, APE, APG + CAP, and APE + CAP. Sterile and untreated biofilm discs were used for verification. Directly after treatment and after 5 days of incubation in medium at 37 °C, samples were prepared for examination by fluorescence microscopy. The relative biofilm fluorescence was measured for quantitative analyses.

Results
Air-polishing with or without CAP removed biofilms effectively. The combination of air-polishing with CAP showed the best cleaning results compared to single treatments, even on day 5. Immediately after treatment, APE + CAP showed insignificant higher cleansing efficiency than APG + CAP.

Conclusions
CAP supports mechanical cleansing and disinfection to remove and inactivate microbial biofilm on implant surfaces significantly. Here, the type of the powder was not important. The highest cleansing results were obtained on sandblasted/etched surfaces.
Clinical relevance.
Microbial residuals impede wound healing and re-osseointegration after peri-implantitis treatment. Air-polishing treatment removes biofilms very effectively, but not completely. In combination with CAP, microbial free surfaces can be achieved. The tested treatment regime offers an advantage during treatment of peri-implantitis.
Effect of malocclusion on jaw motor function and chewing in children: a systematic review
Authors: Alshammari Abdulrahman , Almotairy Nabeel , Kumar Abhishek , Grigoriadis Anastasios 
Published: January 2022

Abstract
Objective
To investigate the effects of dental/skeletal malocclusion and orthodontic treatment on four main objective parameters of chewing and jaw function (maximum occlusal bite force [MOBF], masticatory muscle electromyography [EMG], jaw kinematics, and chewing efficiency/performance) in healthy children.

Materials and methods
Systematic searches were conducted in MEDLINE (OVID), Embase, and the Web of Science Core Collection. Studies that examined the four parameters in healthy children with malocclusions were included. The quality of studies and overall evidence were assessed using the Joanna Briggs Institute and GRADE tools, respectively.

Results
The searches identified 8192 studies; 57 were finally included. The quality of included studies was high in nine studies, moderate in twenty-three studies, and low in twenty-five studies. During the primary dentition, children with malocclusions showed similar MOBF and lower chewing efficiency compared to control subjects. During mixed/permanent dentition, children with malocclusion showed lower MOBF and EMG activity and chewing efficiency compared to control subjects. The jaw kinematics of children with unilateral posterior crossbite showed a larger jaw opening angle and a higher frequency of reverse chewing cycles compared to crossbite-free children. There was a low to moderate level of evidence on the effects of orthodontic treatment in restoring normal jaw function.

Conclusions
Based on the limitations of the studies included, it is not entirely possible to either support or deny the influence of dental/skeletal malocclusion traits on MOBF, EMG, jaw kinematics, and masticatory performance in healthy children. Furthermore, well-designed longitudinal studies may be needed to determine whether orthodontic treatments can improve chewing function in general.

Clinical relevance
Comprehensive orthodontic treatment, which includes evaluation and restoration of function, may or may not mitigate the effects of malocclusion and restore normal chewing function.
Risky interpretations across the length scales: continuum vs. discrete models for soft tissue mechanobiology
Authors: Stracuzzi Alberto , Britt Ben R. , Mazza Edoardo , Ehret Alexander E. 
Published: January 2022

AbstractModelling and simulation in mechanobiology play an increasingly important role to unravel the complex mechanisms that allow resident cells to sense and respond to mechanical cues. Many of the in vivo mechanical loads occur on the tissue length scale, thus raising the essential question how the resulting macroscopic strains and stresses are transferred across the scales down to the cellular and subcellular levels. Since cells anchor to the collagen fibres within the extracellular matrix, the reliable representation of fibre deformation is a prerequisite for models that aim at linking tissue biomechanics and cell mechanobiology. In this paper, we consider the two-scale mechanical response of an affine structural model as an example of a continuum mechanical approach and compare it with the results of a discrete fibre network model. In particular, we shed light on the crucially different mechanical properties of the ‘fibres’ in these two approaches. While assessing the capability of the affine structural approach to capture the fibre kinematics in real tissues is beyond the scope of our study, our results clearly show that neither the macroscopic tissue response nor the microscopic fibre orientation statistics can clarify the question of affinity.
Immuno-histopathologic evaluation of mineralized plasmatic matrix in the management of horizontal ridge defects in a canine model (a split-mouth comparative study)
Authors: Anwar Souzy Kamal , Hamid Hend Mohamed Abdel 
Published: January 2022

AbstractOur research aimed to investigate the effect of combining biphasic calcium phosphate (BCP) alloplast with mineralized plasmatic matrix (MPM) as compared with platelet-rich fibrin (PRF) on the quality and quantity of bone formation and maturation at surgically created horizontal critical-sized ridge defects (HRDs) in a canine model. We used a split-mouth design using the third and fourth mandibular premolars of the mongrel dogs. Twelve defects on the left side (experimental group, I) were managed with MPM composite mixed with BCP alloplast, MPM compact layer. On the right side (control group, II), another 12 defects were managed with PRF mixed with BCP alloplast, followed by the application of PRF compact strips. Finally, both were covered by a collagen membrane. Dogs were euthanized at 4, 8, and 12 weeks, and the studied defects were processed to evaluate treatment outcome, including mean percentage of bone surface area, collagen percentage, and osteopontin (OPN) immunoreaction. Our results revealed that the mean percentage of bone surface area was significantly increased in the experimental group treated with MPM at all time intervals as compared with the PRF group. Decreased collagen percentage and increased OPN immunoreactivity showed significant results in the MPM group as compared with PRF at 4 and 8 weeks postoperatively, respectively. In conclusion, MPM accelerates the formation of superior new bone quality when used in the treatment of HRDs.
Manifolds of mappings on Cartesian products
Authors: Glöckner Helge , Schmeding Alexander 
Published: January 2022

AbstractGiven smooth manifolds $$M_1,\ldots , M_n$$

M
1

,
…
,

M
n

(which may have a boundary or corners), a smooth manifold N modeled on locally convex spaces and $$\alpha \in ({{\mathbb {N}}}_0\cup \{\infty \})^n$$

α
∈

(

N
0

∪

{
∞
}

)

n

, we consider the set $$C^\alpha (M_1\times \cdots \times M_n,N)$$

C
α

(

M
1

×
⋯
×

M
n

,
N
)

of all mappings $$f:M_1\times \cdots \times M_n\rightarrow N$$

f
:

M
1

×
⋯
×

M
n

→
N

which are $$C^\alpha $$

C
α

in the sense of Alzaareer. Such mappings admit, simultaneously, continuous iterated directional derivatives of orders $$\le \alpha _j$$

≤

α
j

in the jth variable for $$j\in \{1,\ldots , n\}$$

j
∈
{
1
,
…
,
n
}

, in local charts. We show that $$C^\alpha (M_1\times \cdots \times M_n,N)$$

C
α

(

M
1

×
⋯
×

M
n

,
N
)

admits a canonical smooth manifold structure whenever each $$M_j$$

M
j

is compact and N admits a local addition. The case of non-compact domains is also considered.
Mosaics of combinatorial designs for information-theoretic security
Authors: Wiese Moritz , Boche Holger 
Published: January 2022

AbstractWe study security functions which can serve to establish semantic security for the two central problems of information-theoretic security: the wiretap channel, and privacy amplification for secret key generation. The security functions are functional forms of mosaics of combinatorial designs, more precisely, of group divisible designs and balanced incomplete block designs. Every member of a mosaic is associated with a unique color, and each color corresponds to a unique message or key value. Every block index of the mosaic corresponds to a public seed shared between the two trusted communicating parties. The seed set should be as small as possible. We give explicit examples which have an optimal or nearly optimal trade-off of seed length versus color (i.e., message or key) rate. We also derive bounds for the security performance of security functions given by functional forms of mosaics of designs.
Understanding virtual patients efficiently and rigorously by combining machine learning with dynamical modelling
Authors: Zhang Tongli , Tyson John J. 
Published: January 2022

AbstractIndividual biological organisms are characterized by daunting heterogeneity, which precludes describing or understanding populations of ‘patients’ with a single mathematical model. Recently, the field of quantitative systems pharmacology (QSP) has adopted the notion ofvirtual patients(VPs) to cope with this challenge. A typical population of VPs represents the behavior of a heterogeneous patient population with a distribution of parameter values over a mathematical model of fixed structure. Though this notion of VPs is a powerful tool to describe patients’ heterogeneity, the analysis and understanding of these VPs present new challenges to systems pharmacologists. Here, using a model of the hypothalamic–pituitary–adrenal axis, we show that an integrated pipeline that combines machine learning (ML) and bifurcation analysis can be used to effectively and efficiently analyse the behaviors observed in populations of VPs. Compared with local sensitivity analyses, ML allows us to capture and analyse the contributions of simultaneous changes of multiple model parameters. Following up with bifurcation analysis, we are able to provide rigorous mechanistic insight regarding the influences of ML-identified parameters on the dynamical system’s behaviors. In this work, we illustrate the utility of this pipeline and suggest that its wider adoption will facilitate the use of VPs in the practice of systems pharmacology.
Loss of Faith and Decrease in Trust in a Higher Source During COVID-19 in Germany
Authors: Büssing Arndt , Baumann Klaus , Surzykiewicz Janusz 
Published: January 2022

AbstractMany people relied on their faith as one resource in order to cope during the COVID-19 pandemic. In Germany, between the eighteen months from June 2020 to November 2021, different participants at different times were assessed during different phases of the COVID-19 pandemic. The total sample of this continuous cross-sectional survey consisted of 4,693 participants. Analyses revealed that with the 2nd wave of the infection and its 2nd lockdown, trust in a Higher Source, along with praying and meditation decreased. Also, the sharp increase in corona-related stressors was associated with a decline of wellbeing and a continuing loss of faith. These developments were observed in both Catholics and Protestants, and in both younger and older persons. In addition, the long phases of insecurity and social isolation lacking the significant support usually given by religious communities may have likewise challenged the religious-coping capacities of religious/spiritual people themselves.
Phenotypic response to soil compaction varies among genotypes and correlates with plant size in sorghum
Authors: Correa José , Postma Johannes A. , Wojciechowski Tobias 
Published: January 2022

Abstract
Aims
Soil compaction is a major yield-reducing factor worldwide and imposes physico-chemical constraints to plant growth and development. Facing limitations, roots can adapt and compensate for loss of functioning through their plasticity. Being primarily a belowground challenge, tolerance to soil compaction needs to be associated with root phenotype and plasticity. It is therefore of importance to distinguish between size-related apparent and size-independent adaptive plasticity. We determined the above- and belowground plasticity of sorghum genotypes varying in overall plant size.

Methods
We quantified plasticity as the degree response (adaptive and apparent plasticity) to soil compaction and conducted two experiments with sorghum and two soil density levels (1.4 and 1.8 Mg m−3). First, we quantified the shoot biomass plasticity of 28 sorghum genotypes. Second, we studied the root plasticity of six genotypes varying in shoot size and tolerance to soil compaction.

Results
Plasticity was correlated with plant biomass with larger genotypes responding earlier and more intensely. Soil compaction affected roots more than shoots and plasticity was expressed foremost in nodal root number and fine root length. Impeded plants produced 35 and 47% less root mass and length, respectively.

Conclusions
Plasticity to soil compaction varies among genotypes, but less-sensitive lines are in general smaller-sized genotypes. The association between tolerance and plant biomass may pose challenges to crop production; however, vigorous genotypes with unresponsive shoots to soil compaction do exist. Maintaining shoot growth relatively stable while the root modifies its structure can be an important adaptation mechanism to soil compaction.
Bridging the Knowledge Gap in Collaborative Research—in Dialogues We Trust
Authors: Melander Anders , Mullern Tomas , Anderssson David , Elgh Fredrik , Löfving Malin 
Published: January 2022

AbstractBy building upon the prior work exploring the nature of practicing and knowing in collaborative research (CR), this article argues that focusing on how trust evolves in collaborative dialogue could enhance the learning potential in CR projects. Drawing from 42 workshops within a CR project, we analyze how dialogue and learning practices develop trust. We use the dialogical framework developed by Walton and Krabbe (1995) to identify and classify 107 dialogues. From our data, we identify three distinct dialogical patterns (educating, inquiring and practicing). These three dialogical patterns are related to four learning practices that are conceptualized as knowledge sharing, knowledge gapping, knowledge bettering and knowledge speculating. Combined, these dialogical patterns and learning practices develop collaborative trust in CR projects. We propose that these results represent an emerging conceptual language that addresses the development of trust in managing CR projects. This conceptual language can both improve managerial practice in the CR context and inspire future theory building.
Hydrogen Isotopes Permeation in Clean or Unoxidized FeCrAl Alloys: A Review
Authors: Garud Yogendra S. , Hoffman Andrew K. , Rebak Raul B. 
Published: January 2022

Abstract
The US Department of Energy is working with fuel vendors to develop accident tolerant fuels (ATF) for the current fleet of light water reactors (LWRs). The ATF should be more resilient to loss of coolant accident scenarios and help extending the life of the operating LWRs. One of the proposed ATF concepts is to use iron-chromium-aluminum (FeCrAl) alloys for the cladding of the fuel. A concern in using ferritic FeCrAl is that this type of cladding may result in an increase in the concentration of tritium in the coolant. The objective of the current critical review is to collect and assess information from the literature regarding diffusion or permeation of hydrogen (H) and its isotopes deuterium (D) and Tritium (T) across industrial alloys (including FeCrAl) used or intended for the nuclear industry. Over a hundred years of data reviewed shows that the solubility of hydrogen in ferritic alloys is lower than in austenitic alloys but hydrogen permeates faster through a ferritic material than through austenitic materials. The tritium permeation rates in FeCrAl alloys are between those in austenitic stainless steels and in ferritic FeCr steels. The activation energy for hydrogen permeation is approximately 30 pct higher in the austenitic alloys compared with the ferritic (typically ∼ 50 kJ/mol in ferritic vs. ∼ 65 kJ/mol in the austenitic). None of the major elements in FeCrAl alloys react with hydrogen to form detrimental hydride phases. The effect of surface oxides on FeCrAl delaying hydrogen entrance into FeCrAl alloy is not part of this review.
Prevalence of Elevated Liver Stiffness Among Potential Candidates for Bariatric Surgery in the United States
Authors: Ciardullo Stefano , Pizzi Mattia , Pizzi Pietro , Oltolini Alice , Muraca Emanuele , Perseghin Gianluca 
Published: January 2022

Abstract
Purpose
Obesity represents a well-known risk factor for metabolic-dysfunction associated fatty liver disease (MAFLD) and its progression towards cirrhosis. The aim of this study is to estimate the proportion of potential candidates to a bariatric surgery intervention that has an elevated liver stiffness on vibration-controlled transient elastography (VCTE).

Materials and Methods
This is a cross-sectional study performed using data obtained during the 2017–2018 cycle of the National Health and Nutrition Examination Survey. Potential candidates for a bariatric surgery intervention from the general US population were identified by applying criteria from international guidelines. All included participants were evaluated by VCTE. A controlled attenuation parameter (CAP) value ≥ 288 dB/m was considered indicative of steatosis while liver stiffness measurement (LSM) was considered elevated if ≥ 9.7 kPa. Multivariable logistic regression models were fitted to identify independent predictors of both outcomes.

Results
A total of 434 participants were included (mean age 42.9 ± 0.6 years; 54.4% women). Among them, 76.7% (95% CI 71.7–81.0) had steatosis, while 23.1% (95% CI 17.8–29.3) had an elevated LSM. Male sex, older age, γ-glutamyltranspeptidase levels, and body mass index (BMI) were independent predictors of steatosis, while BMI was the only independent predictor of elevated LSM. Non-Hispanic black participants were protected from both outcomes, while other ethnicities were not.

Conclusion
The prevalence of elevated LSM is high in potential candidates for a bariatric surgery intervention. Accurate screening for occult advanced liver disease might be indicated in this patient population.

Graphical abstract
Long Non-coding Antisense RNA DDIT4-AS1 Regulates Meningitic Escherichia coli-Induced Neuroinflammation by Promoting DDIT4 mRNA Stability
Authors: Yang Bo , Xu Bojie , Yang Ruicheng , Fu Jiyang , Li Liang , Huo Dong , Chen Jiaqi , Yang Xiaopei , Tan Chen , Chen Huanchun , Wang Xiangru 
Published: January 2022

AbstractOur previous studies have shown that meningitic Escherichia coli can colonize the brain and cause neuroinflammation. Controlling the balance of inflammatory responses in the host central nervous system is particularly vital. Emerging evidence has shown the important regulatory roles of long non-coding RNAs (lncRNAs) in a wide range of biological and pathological processes. However, whether lncRNAs participate in the regulation of meningitic E. coli-mediated neuroinflammation remains unknown. In the present study, we characterized a cytoplasm-enriched antisense lncRNA DDIT4-AS1, which showed similar concordant expression patterns with its parental mRNA DDIT4 upon E. coli infection. DDIT4-AS1 modulated DDIT4 expression at both mRNA and protein levels. Mechanistically, DDIT4-AS1 promoted the stability of DDIT4 mRNA through RNA duplex formation. DDIT4-AS1 knockdown and DDIT4 knockout both attenuated E. coli-induced NF-κB signaling as well as pro-inflammatory cytokines expression, and DDIT4-AS1 regulated the inflammatory response by targeting DDIT4. In summary, our results show that DDIT4-AS1 promotes E. coli-induced neuroinflammatory responses by enhancing the stability of DDIT4 mRNA through RNA duplex formation, providing potential nucleic acid targets for new therapeutic interventions in the treatment of bacterial meningitis.
The Effect of Sleep Deprivation and Subsequent Recovery Period on the Synaptic Proteome of Rat Cerebral Cortex
Authors: Gulyássy Péter , Todorov-Völgyi Katalin , Tóth Vilmos , Györffy Balázs A. , Puska Gina , Simor Attila , Juhász Gábor , Drahos László , Kékesi Katalin Adrienna 
Published: January 2022

AbstractSleep deprivation (SD) is commonplace in the modern way of life and has a substantial social, medical, and human cost. Sleep deprivation induces cognitive impairment such as loss of executive attention, working memory decline, poor emotion regulation, increased reaction times, and higher cognitive functions are particularly vulnerable to sleep loss. Furthermore, SD is associated with obesity, diabetes, cardiovascular diseases, cancer, and a vast majority of psychiatric and neurodegenerative disorders are accompanied by sleep disturbances. Despite the widespread scientific interest in the effect of sleep loss on synaptic function, there is a lack of investigation focusing on synaptic transmission on the proteome level. In the present study, we report the effects of SD and recovery period (RP) on the cortical synaptic proteome in rats. Synaptosomes were isolated after 8 h of SD performed by gentle handling and after 16 h of RP. The purity of synaptosome fraction was validated with western blot and electron microscopy, and the protein abundance alterations were analyzed by mass spectrometry. We observed that SD and RP have a wide impact on neurotransmitter-related proteins at both the presynaptic and postsynaptic membranes. The abundance of synaptic proteins has changed to a greater extent in consequence of SD than during RP: we identified 78 proteins with altered abundance after SD and 39 proteins after the course of RP. Levels of most of the altered proteins were upregulated during SD, while RP showed the opposite tendency, and three proteins (Gabbr1, Anks1b, and Decr1) showed abundance changes with opposite direction after SD and RP. The functional cluster analysis revealed that a majority of the altered proteins is related to signal transduction and regulation, synaptic transmission and synaptic assembly, protein and ion transport, and lipid and fatty acid metabolism, while the interaction network analysis revealed several connections between the significantly altered proteins and the molecular processes of synaptic plasticity or sleep. Our proteomic data implies suppression of SNARE-mediated synaptic vesicle exocytosis and impaired endocytic processes after sleep deprivation. Both SD and RP altered GABA neurotransmission and affected protein synthesis, several regulatory processes and signaling pathways, energy homeostatic processes, and metabolic pathways.