bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploratory study of sea buckthorn enhancing QiangGuYin efficacy by inhibiting CKIP-1 and Notum activating the Wnt/β-catenin signaling pathway and analysis of active ingredients by molecular docking
Authors: Yuan Yi-Feng , Wang Shen , Zhou Hang , Tang Bin-Bin , Liu Yang , Huang Hai , He Cai-Jian , Chen Tian-Peng , Fang Mou-Hao , Liang Bo-Cheng , Mao Ying-De-Long , Qie Feng-Qin , Liu Kang , Shi Xiao-Lin 
Published: October 2022

Background: Sea buckthorn (SBT) is a traditional Chinese medicine (TCM), rich in calcium, phosphorus, and vitamins, which can potentially prevent and treat osteoporosis. However, no research has been conducted to confirm these hypotheses. QiangGuYin (QGY) is a TCM compound used to treat osteoporosis. There is a need to investigate whether SBT enhances QGY efficacy.Objectives: The aim of this study was to explore whether SBT enhances QGY efficacy by inhibiting CKIP-1 and Notum expression through the Wnt/β-catenin pathway. The study also aimed to explore the active components of SBT.Methods: Experimental animals were divided into control, model, QGY, SBT, SBT + Eucommia ulmoides (EU), and SBT + QGY groups. After treatment, bone morphometric parameters, such as estrogen, PINP, and S-CTX levels, and Notum, CKIP-1, and β-catenin expression were examined. Screening of SBT active components was conducted by molecular docking to obtain small molecules that bind Notum and CKIP-1.Results: The results showed that all the drug groups could elevate the estrogen, PINP, and S-CTX levels, improve femoral bone morphometric parameters, inhibit Notum and CKIP-1 expression, and promote β-catenin expression. The effect of SBT + EU and SBT + QGY was superior to the others. Molecular docking identified that SBT contains seven small molecules (folic acid, rhein, quercetin, kaempferol, mandenol, isorhamnetin, and ent-epicatechin) with potential effects on CKIP-1 and Notum.Conclusion: SBT improves bone morphometric performance in PMOP rats by inhibiting CKIP-1 and Notum expression, increasing estrogen levels, and activating the Wnt/β-catenin signaling pathway. Furthermore, SBT enhances the properties of QGY. Folic acid, rhein, quercetin, kaempferol, mandenol, isorhamnetin, and ent-epicatechin are the most likely active ingredients of SBT. These results provide insight into the pharmacological mechanisms of SBT in treating osteoporosis.
Automatic detection of sow posture and estrus based on convolutional neural network
Authors: Xue Hongxiang , Chen Jinxin , Ding Qi’an , Sun Yuwen , Shen Mingxia , Liu Longshen , Chen Xudong , Zhou Junyi 
Published: October 2022

Estrus detection is an essential operation in the breeding of sows, and accurate estrus detection is immensely important to maintain the productivity and reproductive performance of sow. However, traditional sow estrus detection relies on the manually back-pressure test, which is time-consuming and labor-intensive. This study aimed to develop an automatic method to detect estrus. In this study, a model based on the optimized yolov5s algorithm was constructed to detect the four sow postures of standing, sitting, sternum, lateral, and calculated the frequency of posture change in sows. Based on this, we studied the behavior of sows before and after estrus. The method embedded a convolutional block attention module into the backbone network to improve the feature extraction capability of the model. In addition, the object box judgment module was used to avoid interference from other sows in the detection region. Accelerate the optimized model on the TensorRT platform, ensuring that the embedded graphics card can run the model with lower latency. The result shows that the precision of estrus detection is 97.1%, and the accuracy of estrus detection is 94.1%. The processing time of a single image on the embedded graphics card is 74.4 ms, and this method could better meet the estrus detection demand in sow production.
Effects of hanger reflex on the cervical muscular activation and function: A surface electromyography assessment
Authors: Wang Dian , Liu Baoge 
Published: October 2022

Introduction: Cervical muscular dysfunction is closely associated with disorders and neuromuscular diseases of the cervical spine, and the hanger reflex (HR) has the potential to become a rehabilitation method. The muscular electrophysiology mechanism of HR is unclear. This study aims to identify the impacts of HR on cervical rotators’ myoelectrical activity and function.Methods: We designed a self-control clinical trial, and asymptomatic volunteers were continuously included from 1 September 2021 to 30 April 2022 in our department. Rotation tasks were performed on both sides under each of the situations: no HR, unilateral HR, and bilateral HR. Surface electromyography (SEMG) was used to detect the myoelectrical activity of agonistic splenius capitis (SPL), upper trapezius (UTr), and sternocleidomastoid (SCM). The co-contraction ratio (CCR) during rotation tasks was calculated. Correlation analyses and multiple linear regression were performed.Results: Finally, 90 subjects were enrolled (power &gt;90%). The adjusted EMG value (aEMG) of SPL UTr, SCM, and rotating CCR under the unilateral HR and bilateral HR were higher than no HR; the aEMG of SPL and rotating CCR under the bilateral HR were higher than the unilateral HR. Multiple linear regression showed that HR pattern and age were the independent affecting factors for the aEMG of SPL (p &lt; 0.001, p &lt; 0.001), UTr (p &lt; 0.001, p &lt; 0.001), and SCM (p &lt; 0.001, p &lt; 0.001); BMI was an independent affecting factor for the aEMG of SPL (p &lt; 0.001) and SCM (p &lt; 0.001); HR pattern was the only affecting factor for CCR (p &lt; 0.001).Conclusion: HR can increase the cervical rotators’ myoelectrical activities and rotating CCR, and the effects of bilateral HR are greater than unilateral HR, suggesting that bilateral HR has a greater clinical potential to become a rehabilitation method for treating cervical neuromuscular disorders.
The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
Authors: Wang Xuerui , Zou Yangbin , Zhang Ruxuan , Teng Chunyan , Ren Xuejiao , Zhang Haishan , Zhou Liting 
Published: October 2022

Objective: To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions.Methods: Studies comparing serum lipid levels in patients with colorectal serrated lesions and controls were searched in PubMed, Embase, Web of Science, the Cochrane Library, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database. Relevant literature was screened according to the inclusion and exclusion criteria. The mean and standard deviation of the serum lipid levels in patients and controls were extracted from the included literature. The combined weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated using Review Manager 5.0 software to evaluate the relationship between serum lipid levels and colorectal serrated lesions. Publication bias of the included studies was evaluated by the Egger test.Results: Twenty-three studies were included, comprising 2,063 patients and 63,909 controls. The serum high-density lipoprotein cholesterol (HDL-C) levels in the case group was significantly lower than in the control group (WMD = −0.122 mmol/L, 95% CI: 0.170–0.073). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum triglyceride levels in the case group were significantly higher than in the control group, and the WMDs were 0.180 mmol/L (95% CI: 0.061–0.299), 0.155 mmol/L (95% CI: 0.038–0.273), and 0.241 mmol/L (95% CI: 0.181–0.302), respectively.Conclusion: Colorectal serrated lesions may be related to blood lipid levels. Hyperlipidemia might be a risk factor for colorectal serrated lesions.
Counterintuitive consequences of COVID-19 on healthcare workers: A meta-analysis of the relationship between work engagement and job satisfaction
Authors: Yildiz Bora , Yildiz Tayfun , Ozbilgin Mustafa , Yildiz Harun 
Published: October 2022

BackgroundStudies conducted in the health sector have determined a positive relationship between job satisfaction and work engagement. However, this paper reveals that this relationship turns into a negative or non-significant relationship during the COVID-19 pandemic. We explore the reasons for inconsistency in research findings in this critical period through a meta-analysis.MethodsThis study was conducted according to the PRISMA guidelines and PICO framework. Online databases including Web of Science, Scopus, PubMed, ProQuest, Google Scholar, and additional records from other databases were searched without any time limitation, and all studies published in English that reported the correlation between work engagement and job satisfaction were included in the analysis. In total, 36 individual correlation coefficients were synthesized. R statistical language was used to analyze the data.ResultA total of 36 studies with a sample size of 16,087 were synthesized. The overall effect size was found as r = 0.57 (95% CI [0.50–0.64]). While the moderating effect of national culture was not statistically significant, presence of COVID-19 as the significant moderator explained 37.08% of effect size heterogeneity. Such that the presence of COVID-19 has transformed the positive relationship between work engagement and job satisfaction into a negative but statistically non-significant relationship.ConclusionThis study empirically challenges the existing assumptions about the positive link between work engagement and job satisfaction. The results of the research can be a guide for managers and policymakers. Specifically, based on these results, different mechanisms can be put in place to support work engagement and, in turn, job satisfaction in the COVID-19 process.
The mental health status of offshore oil platform workers during the COVID-19 pandemic
Authors: Baygi Fereshteh , Mohammadian Khonsari Nami , Seif Ehsan , Asayesh Hamid , Qorbani Mostafa 
Published: October 2022

BackgroundPrevious studies indicated that offshore workers have a high level of work-related stress on an everyday basis. This study aims to assess the prevalence and determinants of mental health conditions in offshore oil platform workers during the COVID-19 pandemic.MethodsWorkers of three oil and gas platforms were assessed in this cross-sectional study. Their mental status was evaluated by the Posttraumatic Stress Disorder (PTSD-8) questionnaire, and Depression Anxiety, Stress Scales (DASS) questionnaires. Furthermore, we assessed satisfaction with life (SWL) with a single question. Finally, multivariate logistic regression was used to determine the association of demographic and work-related variables with mental health outcomes.ResultsOverall, 278 (Males:197, Females: 81) out of 315 invited workers with a mean age of 35.6 (SD: 7.2) years were included in this study using a random sampling method (participation rate: 88.2%). PTSD symptoms and Insomnia were observed in 9 (3.2%) and 138 (49.6%) of the participants, respectively. The prevalence of stress, anxiety, and depressive symptoms were 72 (25.9%), 70 (24.6%), and 85 (30.5%), respectively. Based on multivariable (adjusted) logistic regression analysis, women had significantly higher odds of stress and anxiety than men; those with an academic education were significantly more dissatisfied with their lives than those without an academic education.ConclusionOur findings revealed a high prevalence of anxiety, depressive symptoms, and stress among offshore oil platformers during the COVID-19 pandemic, especially in women. Indicating that women and those with a higher education level in the oil platform work settings are more susceptible to stressors.
Variations of cannabis-related adverse mental health and addiction outcomes across adolescence and adulthood: A scoping review
Authors: Kaur Navdeep , Bastien Gabriel , Gagnon Lea , Graham Johann , Mongeau-Pérusse Violaine , Bakouni Hamzah , Morissette Florence , Theriault Camille , Fischer Benedikt , Jutras-Aswad Didier 
Published: October 2022

IntroductionEvidence supporting associations between cannabis use and many health outcomes is growing, however it remains unclear how such associations vary across the lifespan. We therefore aim to answer the following questions: (1) Are the risks of cannabis’s adverse effects on mental health and addiction-related outcomes different in adolescents than in adults? (2) What are the relationships between these cannabis’s adverse effects and (a) an individual’s age at first cannabis use, (b) age at assessment, and (c) duration of cannabis use?MethodsWe searched Medline, Embase, CINAHL, and PsychINFO from inception to 18 October 2021. Two reviewers independently screened studies and descriptively synthesized results.ResultsWe included 140 studies. Cannabis effects on mental health and addiction-related outcomes were worse in adolescents, early cannabis initiators and cannabis users who consumed for longest periods. Evidence of worse long-term adverse effects in adolescents was substantial for psychosis, cannabis, and nicotine use disorders; mixed for depression, suicidality, other substance use and disorders; and limited for anxiety. Additionally, acute cannabis exposure had the opposite trend with adults more often reporting adverse effects than adolescents.ConclusionThe available evidence suggests that cannabis use should be delayed as late as possible in adulthood and shortened in duration across the lifespan to decrease the risk of negative outcomes, while emphasizing the need for adapted harm reduction approaches. This scoping review provides evidence on the role of age and duration of exposure as determinants of cannabis-related adverse effects, which may inform prevention and harm reduction strategies.Systematic review registrationhttps://doi.org/10.17605/OSF.IO/BYG72
Health-related quality of life and treatment satisfaction of patients with cardiovascular disease in Ethiopia
Authors: Tito Kebron , Gebremariam Girma Tekle , Beyene Kebede , Sander Beate , Gebretekle Gebremedhin Beedemariam 
Published: October 2022

PurposeCardiovascular disease is the most prevalent health problem associated with poorer health-related quality of life (HRQoL). We aimed to assess HRQoL and treatment satisfaction of cardiovascular disease patients in Ethiopia.MethodsA cross-sectional survey was conducted among adults attending the outpatient cardiac clinic at Tikur Anbessa Specialized Hospital from July to September 2021. Patients were recruited consecutively during follow-up visits. Treatment Satisfaction Questionnaire for Medication and European Quality of life questionnaires were used to evaluate treatment satisfaction and HRQoL, respectively. Kruskal-Wallis and Mann-Whitney U-tests were used to compare utility weights between patient subgroups. Utility values were computed using disutility weights of the Ethiopian general population derived using a hybrid regression model. Tobit regression modeling was used to explore factors associated with poor HRQoL. Statistical significance was determined at p &lt; 0.05.ResultsA total of 357 patients participated in the study with a mean age of 49.3 ± 17.8 years. The most frequently reported health problems were pain/discomfort (75.4%), followed by mobility (73.4%). The median (interquartile range) European Quality questionnaires five dimensions with five levels utility (EQ-5D-5L) and European Quality of life Visual Analog Scale scores were 0.84 (0.55–0.92) and 70.0 (50.0–85.0), respectively. The highest and lowest mean (standard deviation) treatment satisfaction scores were for the convenience and safety satisfaction dimensions: 87.7 (17.9) and 53.1 (33.5), respectively. Unemployment, older age, previous hospital admission, non-adherence to lifestyle modification, and presence of three or more cardiovascular disease factors were significantly negatively associated with HRQoL.ConclusionsOverall, the study found that cardiovascular disease had a profound negative effect on HRQoL and patient treatment satisfaction. We suggest that interventions to enhance HRQoL and treatment satisfactions should focus on modifiable associated factors including lifestyle changes and controlling disease progression.
A study of interactive robot architecture through the practical implementation of conversational android
Authors: Minato Takashi , Sakai Kurima , Uchida Takahisa , Ishiguro Hiroshi 
Published: October 2022

This study shows an autonomous android robot that can have a natural daily dialogue with humans. The dialogue system for daily dialogue is different from a task-oriented dialogue system in that it is not given a clear purpose or the necessary information. That is, it needs to generate an utterance in a situation where there is no clear request from humans. Therefore, to continue a dialogue with a consistent content, it is necessary to essentially change the design policy of dialogue management compared with the existing dialogue system. The purpose of our study is to constructively find out the dialogue system architecture for realizing daily dialogue through implementing an autonomous dialogue robot capable of daily natural dialogue. We defined the android’s desire necessary for daily dialogue and the dialogue management system in which the android changes its internal (mental) states in accordance to the desire and partner’s behavior and chooses a dialogue topic suitable for the current situation. The developed android could continue daily dialogue for about 10 min in the scene where the robot and partner met for the first time in the experiment. Moreover, a multimodal Turing test has shown that half of the participants had felt that the android was remotely controlled to some degree, that is, the android’s behavior was humanlike. This result suggests that the system construction method assumed in this study is an effective approach to realize daily dialogue, and the study discusses the system architecture for daily dialogue.
Case report: Hydrometrocolpos conditioning recurrent urinary tract infections
Authors: Malanowska Ewelina , Krzyścin Mariola , Sowińska-Przepiera Elzbieta , Starczewski Andrzej , Sulikowski Tadeusz , Balzarro Matteo , Rubilotta Emanuele 
Published: October 2022

We present a case of a 12.5-year-old girl who has suffered from recurrent urinary tract infections for many years but has never undergone a detailed diagnostic process. Only as a teenager did she complain of acute pain in her lower abdomen and it turned out that her genital organs had not properly developed. She had an obstructive defect in the reproductive tract. When there was a significant amount of discharge collected in the lumen of the genital tract and the organs had distended, acute pain appeared, which allowed us to make the diagnosis. In the diagnostic process, transperineal ultrasonography turned out to be extremely helpful, allowing us to establish the type and thickness of the obstruction. The patient underwent excision of transverse vaginal septum, and postoperative silicon dilators were used to prevent the recurrence of the obstruction. There was no recurrence of urinary infection or complications during the 11 months of follow-up.
Performing percutaneous nephrolithotomy under modified local anesthesia
Authors: Yu Yue , Hu Jieping , Liu Wei , Peng Zhixiong , Wang Mengzhen , Zhou Xiaochen , Xi Haibo 
Published: October 2022

ObjectiveThis pilot study aimed to assess the practicability and effectiveness of percutaneous nephrolithotomy (PCNL) with vacuum-assisted nephrostomy sheaths for patients under modified local anesthesia (m-LA).MethodsPCNL with a vacuum-assisted nephrostomy sheath under m-LA was performed in 83 patients between November 2020 and May 2021. An 18F or 20F ClearPetra Nephrostomy Sheath connected vacuum aspiration was used in surgery to keep low pressure in the renal pelvis. For LA, lidocaine and ropivacaine hydrochloride were 1:1 mixed and instilled under ultrasound guidance through the percutaneous nephrolithotomy channel directed toward the design calix. Demographic characteristics, stone characteristics, visual analogue scale (VAS) score, vital signs, operation time, complications, and stone clear rate were recorded and analyzed.ResultsAll operations were completed. The mean VAS score was 3.9 ± 1.0. The mean operation time was 55.1 ± 23.6 min. The changes for systolic blood pressure, diastolic blood pressure, and heart rate were 3 ± 21 mmHg, 1 ± 14 mmHg, and −6 ± 14 beats/min, respectively. The change for hemoglobin was −10.7 ± 10.9 g/L. The change for C-reactive protein was 5.39 ± 43.1 mg/L. The total stone-free rate was 69.9% (93.8% for simple stones and 54.9% for complex stones).ConclusionPerforming PCNL with vacuum-assisted nephrostomy sheaths under modified local anesthesia under ultrasound guidance was found to be strongly practical and effective.
Research status and hot topics of the effects of skin innervation on wound healing from 1959 to 2022: A bibliometric analysis
Authors: Song Ru , Wu Zhenjie , Ma Jiaxu , Yin Siyuan , Liu Chunyan , Sun Rui , Cao Guoqi , Lu Yongpan , Chen Aoyu , Zhang Guang , Liu Jian , Wang Yibing 
Published: October 2022

BackgroundSkin innervation plays an important role in wound healing by either direct contact with or indirect secretions that impact skin cells. Many studies in this field have been published; however, there is a lack of bibliometric analyses focusing on the effect of skin innervation on skin wound healing. In this study, we aimed to analyse the research trends, status, and hotspots in this field.MethodsReviews and articles published in English were extracted from the Web of Science Core Collection (WoSCC) database based on subject term searches. Microsoft Office Excel, VOSviewer, and CiteSpace were used to analyse publication date, country or region, institution, author, and author keywords.ResultsA total of 368 papers published between 1959 and 2022 were included in the analysis. Although there was a pulsation during this period, there was an overall upward trend in studies related to the effect of skin innervation on wound healing. The United States, particularly the University of Washington, and Gibran, Nicole S. from the University of Washington, was the most active in this field. Wound Repair and Regeneration published the most relevant literature, and “Calcitonin gene-related peptide: physiology and pathophysiology” had the highest total number of citations. “Diabetic foot ulcer,” “epidermal stem cells,” “mesenchymal stem cells,” and “mast cells” are current and potential future research hotspots.ConclusionThis bibliometric analysis will inform the overall trends in research related to the effect of skin innervation on wound healing, summarise relevant research hotspots, and guide future work.