bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of ruptured scar pattern of human anterior cruciate ligament remnant tissue on tendon‐bone healing in vivo
Authors: Takashima Yoshinori , Matsumoto Tomoyuki , Nakano Naoki , Kamenaga Tomoyuki , Kuroda Yuichi , Hayashi Shinya , Matsushita Takehiko , Niikura Takahiro , Kuroda Ryosuke 
Published: May 2022

AbstractThe purpose of this study was to determine whether the transplantation of human cells from a non‐reattached injured anterior cruciate ligament (ACL) remnant could enhance tendon‐bone healing. Human ACL remnant tissue was classified into two groups based on the morphologic pattern as per Crain's classification: (1) non‐reattachment group (Crain Ⅳ) and (2) reattachment group (Crain Ⅰ–Ⅲ). Seventy‐five 10‐week‐old immunodeficient rats underwent ACL reconstruction followed by intracapsular administration of one of the following: (1) ACL‐derived cells from the non‐reattached remnant (non‐reattachment group) (n = 5), (2) ACL‐derived cells from the reattached tissue (reattachment group) (n = 5), or (3) phosphate‐buffered saline (PBS) only (PBS group) (n = 5). Histological (Weeks 2, 4, and 8), immunohistochemical (Week 2), radiographic (Weeks 0, 2, 4, and 8), and biomechanical (Week 8) assessments were performed. Histological evaluation showed high and early healing, induction of endochondral ossification‐like integration, and mature bone ingrowth at Week 4 in the non‐reattachment group. Microcomputed tomography at Week 4 showed that the tibial bone tunnels in the non‐reattachment group were significantly reduced compared to those in the reattachment and PBS groups. Moreover, biomechanical testing showed that ultimate load‐to‐failure in the non‐reattachment group tended to be larger than that in the reattachment group, though not statistically significant. The enhanced healing potential in the non‐reattachment group was explained by the increase in intrinsic angiogenesis/osteogenesis. In the subacute phase, the ACL‐derived cells with the non‐reattached morphologic pattern showed greater and earlier tendon bone healing compared with the cells obtained from the reattached morphologic pattern.
Automated segmentation of the healed anterior cruciate ligament from T2* relaxometry MRI scans
Authors: Flannery Sean W. , Barnes Dominique A. , Costa Meggin Q. , Menghini Danilo , Kiapour Ata M. , Walsh Edward G. , BEAR Trial Team  , Kramer Dennis E. , Murray Martha M. , Fleming Braden C. 
Published: May 2022

AbstractCollagen organization of the anterior cruciate ligament (ACL) can be evaluated using T2* relaxometry. However, T2* mapping requires manual image segmentation, which is a time‐consuming process and prone to inter‐ and intra‐ segmenter variability. Automating segmentation would address these challenges. A model previously trained using Constructive Interference in Steady State (CISS) scans was applied to T2* segmentation via transfer learning. It was hypothesized that there would be no significant differences in the model's segmentation performance between T2* and CISS, structural measures versus ground truth manual segmentation, and reliability versus independent and retest manual segmentation. Transfer learning was conducted using 54 T2* scans of the ACL. Segmentation performance was assessed with Dice coefficient, precision, and sensitivity, and structurally withT2* value, volume, subvolume proportions, and cross‐sectional area. Model performance relative to independent manual segmentation and repeated segmentation by the ground truth segmenter (retest) were evaluated on a random subset. Segmentation performance was analyzed with Mann–WhitneyUtests, structural measures with Wilcoxon signed‐rank tests, and performance relative to manual segmentation with repeated‐measures analysis of variance/Tukey tests (α = 0.05). T2* segmentation performance was not significantly different from CISS on all measures (p > 0.35). No significant differences were detected in structural measures (p > 0.50). Automatic segmentation performed as well as the retest on all segmentation measures, whereas independent segmentations were lower than retest and/or automatic segmentation (p < 0.023). Structural measures were not significantly different between segmenters. The automatic segmentation model performed as well on the T2* sequence as on CISS and outperformed independent manual segmentation while performing as well as retest segmentation.
Ethnic entrepreneurship: A bibliometric review and future research agenda
Authors: Guerra Fernandes José Afonso , Marques Carla Susana , Silva Rui , Martins Humberto 
Published: May 2022

AbstractThis article provides a bibliometric review based on 267 articles obtained from the Web of Science and SCOPUS databases. The objectives defined for this study were (1) to describe how the publications in this scientific area are organized concerning authors and the evolution of scientific production in the period under analysis; (2) to identify the most cited publications and authors; (3) to understand which scientific journals and countries have the highest scientific production in this area; and (4) to identify future research opportunities. To achieve the defined objectives, the database analysis focused on bibliometric indicators in the first phase. We conclude that ethnic entrepreneurship is a complex and multidimensional phenomenon, having implications in different communities and territories. Therefore, in addition to identifying and analyzing the main streams of the identified literature, this paper not only provides an overview of the state of the art and contributes to understanding ethnic entrepreneurship but also identifies an agenda for future research.
Combined Conventional Ultrasound and Contrast‐Enhanced Computed Tomography for Cervical Lymph Node Metastasis Prediction in Papillary Thyroid Carcinoma
Authors: Zhao Shanshan , Yue Wenwen , Wang Hui , Yao Jincao , Peng Chanjuan , Liu Xiatian , Xu Dong 
Published: May 2022

ObjectivesThis study aimed to evaluate conventional ultrasound (US) combined with contrast‐enhanced computed tomography (CT) of the neck to predict central lymph node metastasis (CLNM) in clinical lymph‐negative patients with papillary thyroid carcinoma (PTC), establish a simple preoperative risk‐scoring model, and validate its effectiveness in a two‐center dataset.MethodsA total of 423 patients with PTC preoperatively evaluated by US and contrast‐enhanced CT were included in the modeling group, and 102 patients from two hospitals were enrolled in the validation group. Independent predictive factors were determined using multivariate logistic regression analysis. Diagnostic performance was evaluated using receiver operating characteristic curve analysis.ResultsThe independent predictive factors for CLNM were age ≤45 years (odds ratio [OR] = 3.950), nodule presence in the non‐upper pole (OR = 2.385), nodule size >12.5 mm (OR = 2.130), Thyroid Imaging Reporting and Data System score ≥9 (OR = 2.857), normalized enhancement CT value ≥0.75 (OR = 3.132), central enhancement (OR = 0.222), and capsular invasion (OR = 3.478). The area under the curve (AUC) of the model was 0.790 (95% confidence interval [CI]: 0.747–0.834), and the sensitivity and specificity were 70.4% and 73.9%, respectively. The AUC in the validation group was 0.827 (95% CI: 0.747–0.907), and the sensitivity and specificity were 88.9% and 63.2%, respectively.ConclusionsWe found conventional US combined with contrast‐enhanced CT of the neck to be useful in predicting CLNM preoperatively and established a simple risk‐scoring model that might help surgeons with appropriate surgical plans and prognostic evaluation.
1‐Year Results of Combined Modified Wendler Glottoplasty with Voice Therapy in Transgender Women
Authors: Rapoport Sarah K. , Park Christopher , Varelas Eleni A , Chang Joseph , Brown Sarah K. , Kinberg Eliezer , Goldberg Leanne , Courey Mark S. 
Published: May 2022

BackgroundTo date, 1‐year evaluation of pitch elevation in patients undergoing modified Wendler glottoplasty (WG) in combination with VT has not been assessed.ObjectivesTo determine whether 1‐year pitch elevation is sustained in patients who undergo modified WG in combination with VT for voice feminization.MethodsA retrospective review of patients who underwent WG in combination with voice therapy (VT) was performed from 2016 to 2020. Charts were reviewed for sustained vowel fundamental frequency (F0/a/), speaking fundamental frequency (SF0), and Trans Woman Voice Questionnaire (TWVQ) at preoperative, initial postoperative (3–6 months after surgery), and 12‐month postoperative visits.ResultsChange in average F0/a/, SF0 and TWVQ was 50.25 Hz, 32.96 Hz, and 32.6 at 12‐months postoperatively compared to preoperative values. Initial and 12‐month postoperative SF0 were significantly higher than preoperative SF0 (Mann–Whitney U test p = 0.0042, p = 0.0010). There was no difference in initial postoperative and 12‐month postoperative SF0 (p = 0.50). TWVQ at 12 months was significantly lower than preoperative TWVQ (ANOVA p < 0.001, Tukey honestly significant difference HSD p < 0.05).ConclusionsPitch elevation remains sustained at one year in patients undergoing modified WG in combination with VT. Modified Wendler glottoplasty combined with VT results in relatively long‐term improvements in voice‐related quality of life and is possibly a beneficial addition in the long‐term management of patients who desire voice feminization.Level of Evidence4 Laryngoscope, 133:615–620, 2023
Surgeon Volume and Laryngectomy Outcomes
Authors: Saraswathula Anirudh , Austin J. Matthew , Fakhry Carole , Vosler Peter S. , Mandal Rajarsi , Koch Wayne M. , Tan Marietta , Eisele David W. , Frick Kevin D. , Gourin Christine G. 
Published: May 2022

ObjectiveTo examine the relationship between surgeon volume and operative morbidity and mortality for laryngectomy.Data SourcesThe Nationwide Inpatient Sample was used to identify 45,156 patients who underwent laryngectomy procedures for laryngeal or hypopharyngeal cancer between 2001 and 2011. Hospital and surgeon laryngectomy volume were modeled as categorical variables.MethodsRelationships between hospital and surgeon volume and mortality, surgical complications, and acute medical complications were examined using multivariable regression.ResultsHigher‐volume surgeons were more likely to operate at large, teaching, nonprofit hospitals and were more likely to treat patients who were white, had private insurance, hypopharyngeal cancer, low comorbidity, admitted electively, and to perform partial laryngectomy, concurrent neck dissection, and flap reconstruction. Surgeons treating more than 5 cases per year were associated with lower odds of medical and surgical complications, with a greater reduction in the odds of complications with increasing surgical volume. Surgeons in the top volume quintile (>9 cases/year) were associated with a decreased odds of in‐hospital mortality (OR = 0.09 [0.01–0.74]), postoperative surgical complications (OR = 0.58 [0.45–0.74]), and acute medical complications (OR = 0.49 [0.37–0.64]). Surgeon volume accounted for 95% of the effect of hospital volume on mortality and 16%–47% of the effect of hospital volume on postoperative morbidity.ConclusionThere is a strong volume‐outcome relationship for laryngectomy, with reduced mortality and morbidity associated with higher surgeon and higher hospital volumes. Observed associations between hospital volume and operative morbidity and mortality are mediated by surgeon volume, suggesting that surgeon volume is an important component of the favorable outcomes of high‐volume hospital care. Laryngoscope, 133:834–840, 2023
Systematic Study of Enzymatic Degradation and Plasmid DNA Complexation of Mucus Penetrating Star‐Shaped Lysine/Sarcosine Polypept(o)ides with Different Block Arrangements
Authors: Skoulas Dimitrios , Fattah Sarinj , Wang Dandan , Cryan Sally‐Ann , Heise Andreas 
Published: May 2022

Abstract8‐Arm star polypep(o)ides comprising cationic polylysine and hydrophilic polysarcosine blocks with a degree of polymerization (DP) of 30 per block are synthesized. Two different block sequences with polylysine as the inner and polysarcosine as the outer block and vice versa are obtained in addition to a statistical copolymer. Analysis of the enzymatic hydrolysis by the proteolytic enzyme trypsin demonstrates a strong dependence on structural arrangements. While polypept(o)ide disintegration is detectible after 24 h by Size Exclusion Chromatography (SEC), significant hydrolysis of the lysine blocks is only monitored after 48 h by fluorescamine labeling of the produced lysine and clearly accelerated in structures with more accessible polylysine blocks. All structures are capable of complexing plasmid DNA and form gene nanomedicines at sizes around or below 200 nm as determined by Dynamic Light Scattering (DLS), Nanoparticle Tracking Analysis (NTA), and Transition Electron Microscopy (TEM). The polyplex formation is slightly enhanced for both block structures over the random copolypept(o)ide. Moreover, it is demonstrated that the polyplexes can transport through mucus. The results highlight the importance of structural control in compartmentalized polymeric gene vector candidates with hydrophilic domains for potential mucosal delivery.
A comparative study between deep inferior epigastric artery perforator flap breast reconstruction and DIEP flap breast reconstruction coupled with vascularized lymph node transfer: Improving the quality of life of patients with breast cancer related lymphedema without affecting donor site outcomes
Authors: Di Taranto Giuseppe , Coleman Grant J. , Hardwicke Joseph , Wallis Katy L. , Skillman Joanna 
Published: May 2022

AbstractBackgroundDespite simultaneous microvascular breast reconstruction (MBR) and vascularized lymph node transfer (VLNT) gaining wide popularity as a potential treatment for breast cancer related lymphedema (BCRL), there is a lack of evidence supporting the procedure. There are few reports in the literature, and no study has compared simple deep inferior epigastric artery perforator (DIEP) to simultaneous DIEP flap and VLNT.Patients and methodsA retrospective analysis of our series of DIEP flaps was conducted. Patients presenting with BCRL who had delayed MBR and simultaneous VLNT were selected. Thirty‐two patients were included and compared with a control group of delayed MBR with DIEP flap alone. Clinical evaluation, circumference reduction rate, and LYMQOL questionnaire were used to compare preoperative and postoperative findings in the study group. A digital version of BREAST Q questionnaire was administered to all patients.ResultsThirty‐two patients were enrolled in the study group, with a mean follow‐up of 42.5 ± 25.7 months and mean age of 54.1 ± 7.8 years. The mean circumference reduction rate was 46.1 ± 52.3, 39 ± 42.3, 47.5 ± 53.5, 39.2 ± 52.4, 33.6 ± 50.1 at the deltoid insertion, above the elbow, below the elbow, at the mid‐forearm and wrist respectively. Postoperative LYMQOL scores significantly improved (function 1.21, appearance 1.15, symptoms 1.34, mood 1.33, overall QOLscore 8.6) from preoperative baseline (p < .001). There was no significant difference in term of outcomes and complications rate of the donor site between the study and control groups.ConclusionsSimultaneous DIEPandVLNT improves the HRQOL of patients with lymphedema. Coupling VLNT with abdominal flap does not increase the morbidity of donor site.
Dihydromyricetin Improves High‐Fat Diet‐Induced Hyperglycemia through ILC3 Activation via a SIRT3‐Dependent Mechanism
Authors: Zhou Jie , Hou Pengfei , Yao Yu , Yue Jing , Zhang Qianyong , Yi Long , Mi Mantian 
Published: May 2022

ScopePrevious studies indicate that dihydromyricetin (DHM) effectively improved glucose homeostasis and alleviated insulin resistance in population‐intervened trials, yet the underlying mechanism remains obscure.Methods and resultsWild‐type male mice and recombinase activating gene 1(Rag1)–/– mice (lacking adaptive immunity lymphocytes) are fed with control, high‐fat diet (HFD), or HFD+DHM diets for 8 weeks. DHM effectively protects HFD feeding mice against hyperglycemia by promoting group 3 innate lymphoid cells (ILC3s) cells proliferation and interleukin 22 (IL‐22) production. Furthermore, IL‐22 secretion induced by DHM increases the expression levels of the tight junction (TJs) molecules to protect the intestinal barrier integrity, thereby decreasing the level of lipopolysaccharides (LPS), an endotoxin that is involved in the regulation of chronic tissue inflammation and insulin resistance. In addition, silent mating‐type information regulation 2 homolog 3 (SIRT3) deficiency results in more serious obesity and intestinal barrier damage following HFD feeding and abolished DHM‐mediated increase in IL‐22 expression levels of ILC3 cells in SIRT3 knockout (SIRT3KO) mice. DHM reduces metabolic stress and enhances mitochondrial respiratory capacity to promote cell proliferation and IL‐22 secretion by activating SIRT3 in ILC3 cellsConclusionsDHM improves IL‐22 production of ILC3 cells and subsequently inhibits intestinal barrier dysfunction to alleviate hyperglycemia partially mediated by SIRT3.
Non‐dystrophic myotonia: 2‐year clinical and patient reported outcomes
Authors: Fullam Timothy R. , Chandrashekhar Swathy , Farmakidis Constantine , Jawdat Omar , Pasnoor Mamatha , Dimachkie Mazen M. , Statland Jeffrey M. ,   the CINCH Consortium
Published: May 2022

AbstractIntroduction/AimsConsistency of differences between non‐dystrophic myotonias over time measured by standardized clinical/patient‐reported outcomes is lacking. Evaluation of longitudinal data could establish clinically relevant endpoints for future research.MethodsData from prospective observational study of 95 definite/clinically suspected non‐dystrophic myotonia participants (six sites in the United States, United Kingdom, and Canada) between March 2006 and March 2009 were analyzed. Outcomes included: standardized symptom interview/exam, Short Form‐36, Individualized Neuromuscular Quality of Life (INQoL), electrophysiological short/prolonged exercise tests, manual muscle testing, quantitative grip strength, modified get‐up‐and‐go test. Patterns were assigned as described by Fournier et al. Comparisons were restricted to confirmed sodium channelopathies (SCN4A, baseline, year 1, year 2: n = 34, 19, 13), chloride channelopathies (CLCN1, n = 32, 26, 18), and myotonic dystrophy type 2 (DM2, n = 9, 6, 2).ResultsMuscle stiffness was the most frequent symptom over time (54.7%–64.7%). Eyelid myotonia and paradoxical handgrip/eyelid myotonia were more frequent in SCN4A. Grip strength and combined manual muscle testing remained stable. Modified get‐up‐and‐go showed less warm up in SCN4A but remained stable. Median post short exercise decrement was stable, except for SCN4A (baseline to year 2 decrement difference 16.6% [Q1, Q3: 9.5, 39.2]). Fournier patterns type 2 (CLCN1) and 1 (SCN4A) were most specific; 40.4% of participants had a change in pattern over time. INQoL showed higher impact for SCN4A and DM2 with scores stable over time.DiscussionSymptom frequency and clinical outcome assessments were stable with defined variability in myotonia measures supporting trial designs like cross over or combined n‐of‐1 as important for rare disorders.
Melt electrowriting: A study of jet diameters and jet speeds along the spinline
Authors: Ashour Sherry , Xu Huaizhong 
Published: May 2022

AbstractAn experimental study on jet dynamics of melt electrowriting is firstly investigated. High‐definition images of jet piling up to 15 layers are recorded. The most notable finding is that despite the variation of jet diameter along the spinline it remained constant at the landing point as the layers elevated. Jet speeds along the spinline can be accurately deduced from the jet diameter, which facilitates the high‐precision printing of melt electrowriting.
Utilization of Mucuna atropurpurea stem fiber as a reinforcement in fiber reinforced plastics
Authors: Senthamaraikannan P. , Saravanakumar S. S. 
Published: May 2022

AbstractThis research investigated the scope of using a fiber harvested from Mucuna atropurpurea (MAF) plant as reinforcement in fiber‐reinforced plastics. An optical microscope and a pycnometer were used to calculate the diameter (289 ± 21 μm) and density (1082 ± 29 kg/m3) of the MAF. Using chemical compositional analysis, 58.74 ± 5.74 wt% cellulose and 16.31 ± 3.21 wt% hemicellulose, and 14.22 ± 3.36 wt% lignin and 0.38 ± 0.08 wt% wax components were found in the MAF. Numerous chemical stretching in the MAF were checked using Fourier transform infrared spectroscopy. Briodo analysis (68.08 kJ/mol) showed the kinetic activation energy of the MAF. Surface morphological inspections suggested surface treatments of MAF due to contaminations and wax on the fiber surface. The statistical analysis conducted for determining the tensile properties of MAF revealed that MAF is a suitable candidate to produce fiber‐reinforced plastics. Characterization of MAF‐reinforced polyester composites showed that 40 mm fiber length and 30 wt% fiber enhanced tensile strength (109.51 ± 2.1 MPa), flexural strength (156.62 ± 3.1 MPa), and hardness (94 ± 4 HRRW). Fractography images of composites with fiber pull‐outs in the MAF‐reinforced plastics were taken for analysis. Less cavities and voids in the 30 wt% MAF‐reinforced composites were found along with reduced water absorption.
Conversion rates in robotic thyroid surgery: A systematic review and meta‐analysis
Authors: Martino Barbara , Nitro Letizia , De Pasquale Loredana , Lozza Paolo , Maccari Alberto , Castellani Luca , Piazzoni Matilde , Cardellicchio Matteo , Bulfamante Antonio Mario , Pipolo Carlotta , Felisati Giovanni , Saibene Alberto Maria 
Published: May 2022

AbstractObjectiveTo define the conversion risk to open procedure during robot‐assisted thyroid surgery (RATS) identifying potential specific subclasses of procedures or accesses at higher conversion risk.MethodsIn a PRISMA‐compliant framework, all original prospective studies providing RATS conversion rates from multiple databases were pooled in a random‐effects meta‐analysis. Conversion rates were compared between different typologies of thyroid surgery and robotic access.Results13 studies were deemed eligible. Four conversions from two studies were reported out of 398 procedures. No significant heterogeneity was observed (Cochran's Q p = 0.932; I2 = 0%). The pooled conversion rate was 1% (95% confidence interval, 0.1%–2%). The ANOVA‐Q test failed to show significant differences when comparing type of thyroid surgery or robotic access (respectively p = 0.766 and p = 0.457).ConclusionWhile the conversion rate appears consistently low across studies, prospective data collection and systematic reporting of procedural complications are required for framing high‐risk procedures and accesses.