bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fe(III)‐Based Layered Double Hydroxides Carrying Model Naproxenate Anions: Compositional and Structural Aspects
Authors: Figueiredo Mariana Pires , Cunha Vanessa R. R. , Cellier Joel , Taviot‐Gueho Christine , Constantino Vera R. L. 
Published: January 2022

AbstractIn this work, Al cation was gradually replaced by FeIII in the composition of Layered Double Hydroxides (LDH) and systematically investigated for LDH application as drug carriers, ultimate aiming to improve their biointegration. The incorporation of FeIII into LDH layers, as well the intercalation of organic anions in the iron‐based materials, is challenging. Several studies approach the intercalation of non‐steroidal anti‐inflammatory drugs such as anionic naproxen (NAP) into Al‐LDH. Thus, NAP was applied here as a model drug for the study of compositional and structural aspects of novel FeIII‐LDH carriers envisaging to shed light on the intercalation of other carboxylate drugs into these materials. LDH of general [M2FeyAl(1‐y)(OH)6]An− compositions (MII=Mg or Zn; An−=anion of charge n) were investigated using two synthetic methods for NAP intercalation. Full X‐ray diffraction profile refinement and a crystal‐geometrical reasoning were used to strengthen the results interpretation. Unlike coprecipitation, in which probably NAP complexation with FeIII hinders LDH‐NAP self‐assembling, topotactic ion exchange demonstrated to be a potential approach.
Highly Flexible and Durable Thermoelectric Power Generator Using CNT/PDMS Foam by Rapid Solvent Evaporation
Authors: Kang Young Hun , Bae Eun Jin , Lee Min‐Hye , Han Mijeong , Kim Bumjoon J. , Cho Song Yun 
Published: January 2022

AbstractUsing a simple, rapid solvent evaporation process, the authors produced 3D carbon nanotube (CNT)/polydimethylsiloxane (PDMS) foams with both high thermoelectric (TE) and good mechanical performance and used them to fabricate highly flexible and durable TE generators. The numerous pores and interfaces in the CNT/PDMS foams, which have porosities exceeding 87%, afford very low thermal conductivity of 0.13 W m−1 K−1. The foam has a zT value of 6.6 × 10−3, which is twice as high as that of pristine CNT foam. Importantly, the CNT/PDMS foam exhibits good tensile strength of 0.78 MPa, elongation greater than 20%, and excellent resilience even at compressive strain of 80%. This foam is used to fabricate a highly flexible TE foam generator that exhibits a moderate output power of 1.9 µW generated from the large temperature gradient of 18.1 K produced by applied heat. The authors also demonstrate a practical TE foam generator that produces sustainable output power of 3.1 µW under a compressive strain of 80% and 38.2 nW under the continuous vibrational stress produced by a car engine. The TE foam generator also exhibits excellent stability and durability under cyclic bending and harsh vibrational stress.
Passive Radiative Cooling Enables Improved Performance in Wearable Thermoelectric Generators
Authors: Liu Yijie , Hou Shuaihang , Wang Xiaodong , Yin Li , Wu Zuoxu , Wang Xinyu , Mao Jun , Sui Jiehe , Liu Xingjun , Zhang Qian , Liu Zhiguo , Cao Feng 
Published: January 2022

AbstractWearable thermoelectric generators have great potential to be utilized as the power supply for wearable electronics. However, the limited temperature difference across the thermoelectric generators significantly degrades the output performance, which is anticipated to be improved by enhancing the thermal radiation at the cold side without extra energy consumption. In this paper, the impact of thermal radiation on the performance of thermoelectric generators in different environments is simulated and the enhanced performance in a wearable thermoelectric generator combined with a radiative cooling coating is experimentally verified. Compared with the pristine device, the wearable thermoelectric generator with radiative cooling coating can not only achieve an ≈128% improvement of output power in exposed environments, but also exhibit an ≈96% improvement of output power in non‐exposed environments. The indoor output performance of the wearable thermoelectric generator with a radiative cooling coating due to its stable voltage output is extensively investigated, which shows an output power density of ≈5.5 μW cm–2 at the indoor temperature of 295 K, doubled that without a radiative cooling coating. This work paves a new way for further enhancing the performance of thermoelectric generators via passive radiative cooling.
A systems view of responding to the COVID‐19 pandemic: A causal loop model for Taiwan's approach
Authors: Hsiao Chih‐Tung , Chen Chun‐Cheng , Lin Lee‐Kai , Liu Chung‐Shu 
Published: January 2022

AbstractSince the worldwide outbreak of the COVID‐19 pandemic in December 2019, Taiwan has successfully stopped the spread of COVID‐19. The policies and works of the epidemic control are a complex and dynamic process. This study applied the methodology of system dynamics to explore the structure of the COVID‐19 epidemic control system in Taiwan and analysed its system behaviours. The results show that the system is composed of key subsystems, such as national health insurance and quarantine, combined with government policies. Joint efforts among the central and local governments and the general public have been made to strengthen the quarantine of border entrants, encourage the public to wear masks and employ technology for contact tracing and tracking down those being tested positive with COVID‐19. Together with the efficient increase in the capacity of testing and medical treatments, these measures can effectively reach a balance between epidemic control and economic activities.
Safety of jidabokuippo administration based on adverse event rate
Authors: Kitamura Toshiharu , Nakae Hajime , Irie Yasuhito , Satoh Kasumi , Hirasawa Nobuhisa , Kameyama Koumei , Suzuki Yuya , Maeno Kyohei , Yoshida Kenji , Okuyama Manabu 
Published: January 2022

AbstractAimThe incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate.MethodsAdverse events to JDI treatment were observed in 14 patients (adverse event group) while 1090 had none (non‐adverse event group). We compared age, sex, comorbidity, dose, dosing period, concomitant use of Kampo prescription, and concomitant use of analgesics between these two groups.ResultsThe adverse event rate was 1.3%. The most common adverse event was diarrhea caused by rhubarb rhizome (0.6%). The adverse event rate of Glycyrrhiza‐induced pseudoaldosteronism was 0.3%. All symptoms improved on JDI withdrawal or taking JDI after meals. Median duration of JDI was significantly shorter in the adverse event group than in the non‐adverse event group (P = 0.0141).ConclusionThe adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome and Glycyrrhiza root.
The role of gut microbiota in infectious diseases
Authors: Cai Yongjie , Chen Lingming , Zhang Sien , Zeng Lingchan , Zeng Gucheng 
Published: January 2022

AbstractThe intestine, the largest immune organ in the human body, harbors approximately 1013 microorganisms, including bacteria, fungi, viruses, and other unknown microbes. The intestine is a most important crosstalk anatomic structure between the first (the host) and second (the microorganisms) genomes. The imbalance of the intestinal microecology, especially dysbiosis of the composition, structure, and function of gut microbiota, is linked to human diseases. In this review, we investigated the roles and underlying mechanisms of gut microecology in the development, progression, and prognosis of infectious diseases. Furthermore, we discussed potential new strategies of prevention and treatment for infectious diseases based on manipulating the composition, structure, and function of intestinal microorganisms in the future.This article is categorized under:
Infectious Diseases > Molecular and Cellular Physiology
Identification of QTLs affecting post-anthesis heat stress responses in European bread wheat
Authors: Touzy Gaëtan , Lafarge Stéphane , Redondo Elise , Lievin Vincent , Decoopman Xavier , Le Gouis Jacques , Praud Sébastien 
Published: January 2022

AbstractKey messageThe response of a large panel of European elite wheat varieties to post-anthesis heat stress is influenced by 17 QTL linked to grain weight or the stay-green phenotype.AbstractHeat stress is a critical abiotic stress for winter bread wheat (Triticum aestivumL.) especially at the flowering and grain filling stages, limiting its growth and productivity in Europe and elsewhere. The breeding of new high-yield and stress-tolerant wheat varieties requires improved understanding of the physiological and genetic bases of heat tolerance. To identify genomic areas associated with plant and grain characteristics under heat stress, a panel of elite European wheat varieties (N = 199) was evaluated under controlled conditions in 2016 and 2017. A split-plot design was used to test the effects of high temperature for ten days after flowering. Flowering time, leaf chlorophyll content, the number of productive spikes, grain number, grain weight and grain size were measured, and the senescence process was modeled. Using genotyping data from a 280 K SNP chip, a genome-wide association study was carried out to test the main effect of each SNP and the effect of SNP × treatment interaction. Genotype × treatment interactions were mainly observed for grain traits measured on the main shoots and tillers. We identified 10 QTLs associated with the main effect of at least one trait and seven QTLs associated with the response to post-anthesis heat stress. Of these, two main QTLs associated with the heat tolerance of thousand-kernel weight were identified on chromosomes 4B and 6B. These QTLs will be useful for breeders to improve grain yield in environments where terminal heat stress is likely to occur.
Veränderungen der Kontextfaktoren und deren Auswirkungen auf die Arzt-Patient-Beziehung
Authors: Steinmair D. , Ronge-Toloraya A. , Löffler-Stastka H. 
Published: January 2022

ZusammenfassungTherapeutisches Wirken wird durch begünstigende Kontextfaktoren erleichtert, wobei therapeutische Interventionen gleichzeitig Anregung sein können, Kontextfaktoren zu verändern. Kommunikation und Therapie werden durch eine gute therapeutische Beziehung erst ermöglicht, vor allem unter erschwerten inneren und äußeren Bedingungen.
Students home alone—profiles of internal and external conditions associated with mathematics learning from home
Authors: Hofer Sarah I. , Reinhold Frank , Koch Marco 
Published: January 2022

AbstractsThis study aims at describing differences in internal and external resources of students to handle mathematics learning from home. Based on data from N = 223 7th-grade secondary school students gathered via an online survey at the end of the first school year during the COVID-19 pandemic, we used latent profile analysis to identify student profiles defined by the internal factors perceived value and success of students’ math learning from home and the external factors family support and teacher support—all specifically related to home learning. A number of general learning conditions, comprising internal (e.g., sustained attention) and external factors (e.g., socioeconomic status), are included as outcome variables. The best-fitting four-profile solution suggests one profile with comparably unfavorable internal and external resources. About 35% of the students are assigned to that profile. The other three profiles show combinations of, relative to the sample, more and less promising specific home learning and general learning conditions suggesting that these students have different resources available in the face of learning mathematics from home.
Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting
Authors: Nagy Attila , Horváth Alpár , Farkas Árpád , Füri Péter , Erdélyi Tamás , Madas Balázs G. , Czitrovszky Aladár , Merkely Béla , Szabó Attila , Ungvári Zoltán , Müller Veronika 
Published: January 2022

Abstract
Respiratory transmission of SARS-CoV-2 from one older patient to another by airborne mechanisms in hospital and nursing home settings represents an important health challenge during the COVID-19 pandemic. However, the factors that influence the concentration of respiratory droplets and aerosols that potentially contribute to hospital- and nursing care-associated transmission of SARS-CoV-2 are not well understood. To assess the effect of health care professional (HCP) and patient activity on size and concentration of airborne particles, an optical particle counter was placed (for 24 h) in the head position of an empty bed in the hospital room of a patient admitted from the nursing home with confirmed COVID-19. The type and duration of the activity, as well as the number of HCPs providing patient care, were recorded. Concentration changes associated with specific activities were determined, and airway deposition modeling was performed using these data. Thirty-one activities were recorded, and six representative ones were selected for deposition modeling, including patient’s activities (coughing, movements, etc.), diagnostic and therapeutic interventions (e.g., diagnostic tests and drug administration), as well as nursing patient care (e.g., bedding and hygiene). The increase in particle concentration of all sizes was sensitive to the type of activity. Increases in supermicron particle concentration were associated with the number of HCPs (r = 0.66; p < 0.05) and the duration of activity (r = 0.82; p < 0.05), while submicron particles increased with all activities, mainly during the daytime. Based on simulations, the number of particles deposited in unit time was the highest in the acinar region, while deposition density rate (number/cm2/min) was the highest in the upper airways. In conclusion, even short periods of HCP-patient interaction and minimal patient activity in a hospital room or nursing home bedroom may significantly increase the concentration of submicron particles mainly depositing in the acinar regions, while mainly nursing activities increase the concentration of supermicron particles depositing in larger airways of the adjacent bed patient. Our data emphasize the need for effective interventions to limit hospital- and nursing care-associated transmission of SARS-CoV-2 and other respiratory pathogens (including viral pathogens, such as rhinoviruses, respiratory syncytial virus, influenza virus, parainfluenza virus and adenoviruses, and bacterial and fungal pathogens).
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson’s Disease?
Authors: Yin Sijia , Han Chao , Xia Yun , Wan Fang , Hu Junjie , Kou Liang , Sun Yadi , Wu Jiawei , Li Yunna , Zhou Qiulu , Xiong Nian , Huang Jinsha , Wang Tao 
Published: January 2022

AbstractParkinson’s disease (PD) is an incurable neurodegenerative disease characterized by aggregation of pathological alpha-synuclein (α-syn) and loss of dopaminergic neuron in the substantia nigra. Inhibition of phosphorylation of the α-syn has been shown to mediate alleviation of PD-related pathology. Protein phosphatase 2A (PP2A), an important serine/threonine phosphatase, plays an essential role in catalyzing dephosphorylation of the α-syn. Here, we identified and validated cancerous inhibitor of PP2A (CIP2A), as a potential diagnostic biomarker for PD. Our data showed that plasma CIP2A concentrations in PD patients were significantly lower compared to age- and sex-matched controls, 1.721 (1.435–2.428) ng/ml vs 3.051(2.36–5.475) ng/ml, p < 0.0001. The area under the curve of the plasma CIP2A in distinguishing PD from the age- and sex-matched controls was 0.776. In addition, we evaluated the role of CIP2A in PD-related pathogenesis in PD cellular and MPTP-induced mouse model. The results demonstrated that CIP2A is upregulated in PD cellular and MPTP-induced mouse models. Besides, suppression of the CIP2A expression alleviates rotenone induced aggregation of the α-syn as well as phosphorylation of the α-syn in SH-SY5Y cells, which is associated with increased PP2A activity. Taken together, our data demonstrated that CIP2A plays an essential role in the mechanisms related to PD development and might be a novel PD biomarker.
Prävention und Ungewissheiten des Aufwachsens von Kindern
Authors: Schmidt Friederike 
Published: January 2022

ZusammenfassungPräventive Versuche der Reduktion von Ungewissheiten haben in den letzten Jahrzehnten an Bedeutung gewonnen. Das Beispiel der Ernährungsprävention zeigt, dass zunehmend in der frühesten Lebensphase von Kindern angesetzt wird. Darüber gewinnen biographisch frühe Versuche der Normalisierung von Subjekten und deren Lebensführung an Relevanz.
Backbone chemical shift assignment and dynamics of the N-terminal domain of ClpB from Francisella tularensis type VI secretion system
Authors: Mushtaq Ameeq Ul , Ådén Jörgen , Alam Athar , Sjöstedt Anders , Gröbner Gerhard 
Published: January 2022

AbstractThe Hsp100 family member ClpB is a protein disaggregase which solubilizes and reactivates stress-induced protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. In the pathogenic bacterium Francisella tularensis, ClpB is involved in type VI secretion system (T6SS) disassembly through depolymerization of the IglA-IglB sheath. This leads to recycling and reassembly of T6SS components and this process is essential for the virulence of the bacterium. Here we report the backbone chemical shift assignments and 15N relaxation-based backbone dynamics of the N-terminal substrate-binding domain of ClpB (1-156).
Backbone NMR assignment of the nucleotide binding domain of the Bacillus subtilis ABC multidrug transporter BmrA in the post-hydrolysis state
Authors: Pérez Carrillo Victor Hugo , Rose-Sperling Dania , Tran Mai Anh , Wiedemann Christoph , Hellmich Ute A. 
Published: January 2022

AbstractATP binding cassette (ABC) proteins are present in all phyla of life and form one of the largest protein families. The Bacillus subtilis ABC transporter BmrA is a functional homodimer that can extrude many different harmful compounds out of the cell. Each BmrA monomer is composed of a transmembrane domain (TMD) and a nucleotide binding domain (NBD). While the TMDs of ABC transporters are sequentially diverse, the highly conserved NBDs harbor distinctive conserved motifs that enable nucleotide binding and hydrolysis, interdomain communication and that mark a protein as a member of the ABC superfamily. In the catalytic cycle of an ABC transporter, the NBDs function as the molecular motor that fuels substrate translocation across the membrane via the TMDs and are thus pivotal for the entire transport process. For a better understanding of the structural and dynamic consequences of nucleotide interactions within the NBD at atomic resolution, we determined the 1H, 13C and 15N backbone chemical shift assignments of the 259 amino acid wildtype BmrA-NBD in its post-hydrolytic, ADP-bound state.
High dissociatives, nature versus nurture?
Authors: Pérez-Fabello María José , Campos Alfredo 
Published: January 2022

AbstractNon-pathological dissociative experiences are common among the general population, and anyone may experience them to some degree. Thus, the aim of this study was to assess the degree of dissociative experiences such as fantasy proneness, imagination, and absorption in fine arts undergraduates prior to beginning their artistic studies, and at the end of their studies at the faculty of fine arts. Moreover, education undergraduates were used as a comparison group. The sample consisted of 440 undergraduates (204 fine arts, and 236 education undergraduates; 224 first-year undergraduates, and 216 fourth-year undergraduates), who were administered three dissociative experiences tests: Dissociative Ability Scale, Dissociative Experiences Scale, and Questionnaire of Experiences of Dissociation. The working hypotheses were substantiated with dissociative experiences being a distinctive personality trait of fine arts undergraduates. We have found a grade level difference between first-year and fourth-year fine arts undergraduates, although the study does not examine the nature of the change itself. The results are discussed in the light of previous studies, and new lines of research proposed.
Foliation of an Asymptotically Flat End by Critical Capacitors
Authors: Fall Mouhammed Moustapha , Minlend Ignace Aristide , Ratzkin Jesse 
Published: January 2022

AbstractWe construct a foliation of an asymptotically flat end of a Riemannian manifold by hypersurfaces which are critical points of a natural functional arising in potential theory. These hypersurfaces are perturbations of large coordinate spheres, and they admit solutions of a certain over-determined boundary value problem involving the Laplace–Beltrami operator. In a key step we must invert the Dirichlet-to-Neumann operator, highlighting the nonlocal nature of our problem.
Partial Regularity for Harmonic Maps into Spheres at a Singular or Degenerate Free Boundary
Authors: Moser Roger , Roberts James 
Published: January 2022

AbstractWe prove partial regularity of weakly stationary harmonic maps with (partially) free boundary data on manifolds where the domain metric may degenerate or become singular along the free boundary at the rate $$d^\alpha $$

d
α

for the distance function d from the boundary.
Temporal observation of endoscopic and histological findings of gastritis after administration of an immune checkpoint inhibitor: a case report
Authors: Saito Keita , Ozono Daiki , Nagumo Hironobu , Yoshimura Masayo , Masuzawa Yoko 
Published: January 2022

AbstractA 71-year-old Japanese man was treated with 200 mg of pembrolizumab for lung adenocarcinoma with multiple bone metastases at the Department of Respiratory Medicine of Kameda General Hospital. After 19 treatment courses, he complained of epigastric pain before meals. Upper gastrointestinal endoscopy showed multiple erosions in the gastric antrum, and antacids were administered at follow-up. After 27 treatment courses, the patient underwent another endoscopy because of anorexia. The erosions were enlarged and had increased from the gastric antrum to the greater curvature of the body. Histological biopsy showed lymphocytic infiltration with a predominance of CD8-positive T cells. The patient had previously been treated for Helicobacter pylori infection, and we suspected drug-induced gastritis due to the administration of immune checkpoint inhibitors in the course of the disease. Pembrolizumab was discontinued, and the patient’s symptoms gradually improved. Endoscopic examinations were performed 2, 5, and 9 months after discontinuation of pembrolizumab, and improvement in mucosal findings and decreased lymphocyte infiltration were confirmed each time. The patient has remained without any relapse of symptoms for more than 1 year after discontinuing treatment.