bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR-153-5p suppresses the proliferation, invasion and migration of malignant meningioma via the MEK/ERK signaling pathway by targeting GAB1
Authors: Chen Weifeng , Jiahui Zhao , Wu Qianlan , Shi Yunpeng , Yan Hongjing , Zhen Wu , Lei Chen , Zhao Zongmao 
Published: September 2022

Abstract
Aims:This study aimed to determine the role and correlation of miR-153-5p and GAB1 in the proliferation, invasion and migration of malignant meningioma.
Background:Meningiomas are the most common primary intracranial tumor in adults.For meningioma, the only effective treatment and targeted therapy is excision and radiotherapy.However,some meningiomas are prone to recurring due to specific disease sites or an invasion of blood vessels and nerves, and the prognosis is poor.To discover biomarkers and develop targeted therapies, it is necessary to better understand meningioma oncogenesis.
Methods:Human meningioma tissues were collected from patients diagnosed in pathological examinations. In addition, human malignant meningioma cell lines IOMM-Lee was included. Quantitative RT-PCR was used to detect the miR-153-5p and GAB1 level in the clinical tissues and cell lines.Immunohistochemistry was used to detect GAB1 expression.The specific binding site between miR-153-5p and GAB1 was predicted using bioinformatics, and dual luciferase assay was used to confirm their specific binding relationship. In IOMM-Lee, miR-153-5p was artificially overexpressed or suppressed and target gene expression GAB1 was blocked by siRNA. Cell proliferation, invasion and migration were measured using CCK-8,Transwell and Wound-healing assays.The activity of the MEK/ERK pathway was evaluated by detecting the key factors through Western blotting.
Results:We found that miR-153-5p expression was low and GAB1 mRNA was high in meningioma tissues and IOMM-Lee cell lines. GAB1 is a direct target gene of miR-153-5p.Both miR-153-5p overexpression and GAB1 silencing inhibited malignant meningioma cells proliferation, migration and invasion,and GAB1 silencing partially blocked the effect of miR-153-5p silencing in these respects.We also confirmed that miR-153-5p might regulate MEK/ERK pathway activation by inhibiting GAB1 expression.
Conclusions: miR-153-5p suppresses the proliferation, invasion and migration of malignant meningioma via the MEK/ERK signaling pathway by targeting GAB1, defining miR-153-5p and GAB1 as a potential target for the diagnosis and treatment of malignant meningioma.
Sociodemographic effects on pandemic fatigue are multifaceted and context-specific: a longitudinal analysis of physical distancing adherence
Authors: Leach Damon , Morris Keeley J. , Fiecas Mark , Tarr Gillian A.M. 
Published: September 2022

Abstract
Pandemic fatigue emerged early during the COVID-19 pandemic and remains a concern as new variants emerge and ongoing public health measures are needed to control them. A wide range of factors can affect pandemic fatigue, but empiric research indicating which may be most important to adherence in specific populations is lacking. Here we report results from a longitudinal study of physical distancing, in which we found that changes in contact rates over time differed according to several sociodemographic characteristics. Meaningful effects emerged along lines of age, gender, race/ethnicity, education, household composition, and access to transportation. Furthermore, the factors influencing the rate of change in contact rates differed by the type or setting of the contact, for example contacts as a result of visiting another person’s home versus during a retail outing. These results provide evidence for potential mechanisms by which pandemic fatigue has resulted in lower physical distancing adherence.
Development of a Universal Landslide Hazard Potential Model for Mudrocks - Fuzzy Logic and Molecular-level Modeling approaches
Authors: ur-Rehman Habib , Abduljauwad Sahel N. , Naeemuddin Muhammad 
Published: September 2022

Abstract

The phenomenon of the reduction of shear strength due to moisture-induced swelling and subsequent slaking of the mudrocks is one of the leading causes of landslide hazards in mountainous terrain. In the practice, empirical/semi-empirical approaches adopted for the determination of this hazard are mostly based on macro-level factors. But they do not comprehensively cover the micro-level factors, which contribute to the complex swelling/slaking process. Therefore, a comprehensive fuzzy-logic-based model was developed in this study, which includes both the macro-level landslide contributing factors and the micro-level factors, such as mineralogy, cementation, cation exchange capacity, in situ moisture content, density, and stress state. The model resulted from the molecular simulations of swelling and the subsequent slaking processes using Monte Carlo, molecular mechanics, and molecular dynamics. The results of the micro-level model are incorporated into the fuzzy-logic model to create a universal landslide hazard potential model for the slopes composed of mudrocks. The micro-level behaviour is incorporated in the coupled model via the cohesive energy density parameter for the mudrocks. The final coupled model was verified through the accurate prediction of the landslides and also by comparing the predicted terminal water content with the water content of the mudrock samples collected from the triggered landslides.
YOLO Based Multi-Objective Vehicle Detection and Tracking
Authors: costel tchanchou , XIN JIANG , YU WANG , RUI ZHENG 
Published: September 2022

Abstract
Vehicle recognition and monitoring are gaining importance in traffic management. However, due to the various sizes of cars, detection remains a difficulty, which directly impacts the accuracy of vehicle counts. The suggested vehicle recognition and counting method first extracts the highway road surface in the image and divides it into a distant regions. A newly developed segmentation strategy in the proposed vehicle identification and counting system first extracts a nd s eparates t he highway road Turface in the image into a distant region and a proximal area; the method is crucial for improving vehicle detection. The aforementioned locations are then sent to the YOLOv5m network to determine the vehicle’s kind and position. Finally, the ORB algorithm is utilized to create vehicle trajectories, which may be used to estimate the driving direction of the vehicle and determine the number of distinct cars. Several traffic surveillance recordings from various settings are utilized to validate the suggested meUhodoMoHZ. 5he experimental findings demonstrate that the suggested segmentation approach may give greater detection accuracy, particularly for the detection of little automobile things. In addition, the vehicle detection performance was significantly improved by 99.39 % of m AP compared to the Yolov5 basic. This work has broad practical implications for managing and controlling vehicle objects in traffic scenes.
Embedding-aided network dismantling
Authors: Osat Saeed , Papadopoulos Fragkiskos , Teixeira Andreia Sofia , Radicchi Filippo 
Published: September 2022

Abstract
Optimal percolation concerns the identification of the minimum-cost strategy for the destruction of any extensive connected components in a network. Solutions of such a dismantling problem are important for the design of optimal strategies of disease containment based either on immunization or social distancing. Depending on the specific variant of the problem considered, network dismantling is performed via the removal of nodes or edges, and different cost functions are associated to the removal of these microscopic elements. In this paper, we show that network representations in geometric space can be used to solve several variants of the network dismantling problem in a coherent fashion. Once a network is embedded, dismantling is implemented using intuitive geometric strategies. We demonstrate that the approach well suits both Euclidean and hyperbolic network embeddings. Our systematic analysis on synthetic and real networks demonstrates that the performance of embedding-aided techniques is comparable to, if not better than, the one of the best dismantling algorithms currently available on the market.
Liver fibrosis is associated with impaired bone mineralization and microstructure in obese individuals with non-alcoholic fatty liver disease.
Authors: Barchetta Ilaria , Lubrano Carla , Cimini Flavia Agata , Dule Sara , Passarella Giulia , Dellanno Arianna , Biasio Alberto Di , Leonetti Frida , Silecchia Gianfranco , Lenzi Andrea , Cavallo Maria Gisella 
Published: September 2022

Abstract
Background and purpose

Chronic liver diseases are associated with increased bone fracture risk, mostly in end-stage disease and cirrhosis; besides, data in non-alcoholic fatty liver disease (NAFLD) are limited. Aims of this study was to investigate bone mineralization and microstructure in obese individuals with NAFLD in relation to the estimated liver fibrosis.

Methods

We analyzed data from 1872 obese individuals (44.6 ± 14.1 years, M/F: 389/1483; BMI: 38.3 ± 5.3 kg/m2) referring to the Endocrinology outpatient clinics of Sapienza University, Rome, Italy. Participants underwent clinical work-up, Dual-Energy X-ray Absorptiometry for assessing bone mineral density (BMD) and microarchitecture (trabecular bone score, TBS). Liver fibrosis was estimated by Fibrosis Score 4 (FIB-4). Serum parathyroid hormone (PTH), 25(OH) vitamin D, osteocalcin and IGF-1 levels were measured.

Results

Individuals with osteopenia/osteoporosis had greater FIB-4 than those with normal BMD (p < 0.001). FIB-4 progressively increased in presence of degraded bone microarchitecture (p < 0.001) and negatively correlated with the serum osteocalcin (p < 0.001) and IGF-1 (p < 0.001), which were both reduced in presence of osteopenia/osteoporosis. FIB-4 predicted IGF-1 reduction in multivariable regression models adjusted for confounders (β: −0.18, p < 0.001). Higher FIB-4 predicted bone fragility with OR 3.8 (95%C.I:1.5–9.3); this association persisted significant after adjustment for sex, age, BMI, diabetes, smoking status and PTH at the multivariable logistic regression analysis (OR 1.91 (95%C.I:1.15–3.17), p < 0.01), with AUROC = 0.842 (95%C.I:0.795–0.890; p < 0.001).

Conclusion

Our data indicate the presence of a tight relation between NAFLD-related liver fibrosis, lower bone mineral density and degraded microarchitecture in obese individuals, suggesting potential common pathways underlying liver and bone involvement in insulin-resistance associated disorders.
DCP: a pipeline toolbox for diffusion connectome
Authors: Huang Weijie , Fu Anguo , Shu Ni 
Published: September 2022

Abstract
The brain structure network constructed from diffusion magnetic resonance imaging (dMRI) reflects the anatomical connections between brain regions, so the brain structure network can quantitatively describe the anatomical connectivity pattern of the entire brain. This method has been widely used in scientific research. While many toolboxes facilitating the construction of white matter networks and topological analysis have been developed, fully automated network analysis based on dMRI data in the Windows Operating System remains challenging. Here, we developed a MATLAB toolbox named “Diffusion Connectome Pipeline” (DCP) for fully automated construction of brain structure networks and analyzing networks. The toolbox integrates modules of a few developed packages, including Diffusion Toolkit, DiffusionKit, SPM, CAMINI, and MRIcron. It can process any number of raw dMRI datasets from different subjects in either DICOM or NIfTI format. It is also compatible with processed files from HCP and UK Biobank. Moreover, DCP has a friendly graphical user interface running on the Windows Operating System, which enables users to configure their processing pipeline without any programming. As an open-source package, DCP is freely available on https://www.nitrc.org/projects/dcp and will be regularly updated. This novel toolbox is expected to substantially standardize and facilitate human brain structural connectome studies.
Developmental screening of full-term infants at 16 to 18 months of age after in-utero exposure to maternal SARS-CoV-2 infection
Authors: Shah Aashish , Howell Heather , Kazmi Sadaf , Zaccario Michele , Sklamberg Felice , Groth Taylor , Martindale Pia , Dreyer Benard , Verma Sourabh 
Published: September 2022

Abstract
Full-term infants born to mothers with SARS-CoV-2 infection may be at increased risk for neurodevelopmental delays at 16 to 18 months of life. Infants born to the mothers with mild symptoms had no differences in outcomes during developmental screening than those born to asymptomatic mothers with SARS-CoV-2.
Hypo- and Hyper-perfusion in MCI and AD Identified by Different ASL MRI Sequences
Authors: Camargo Aldo , Wang Ze 
Published: September 2022

Abstract
Arterial spin labeling (ASL) perfusion MRI has been increasingly used in Alzheimer's Disease (AD) research. Because ASL implementations differ greatly in signal preparations and data acquisition strategies, both resulting in a large difference of signal-to-noise ratio (SNR), a comparison of different sequences that are widely available in major MR vendors is vital. The purpose of this study was to compare three types of commercial ASL MRI methods in Siemens and GE scanners: 2D Pulsed ASL (PASL), 3D Background Suppressed (BS) PASL, and 3D BS Pseudo-Continuous ASL (PCASL). We used data from 100 healthy control (NC), 75 mild cognitive impairment (MCI), and 57 Alzheimer’s disease (AD) subjects from the AD neuroimaging initiative (ADNI). Both cross-sectional perfusion difference and perfusion vs clinical assessment correlations were compared across the three types of data. Different perfusions change patterns were observed, being 3D + BS ASL more sensitive than 2D ASL and 3D PASL the most sensitive. Significant lower CBF were found in MCI compared with NC subjects in the left and right middle temporal gyrus, right cerebellum, and left postcentral gyrus; and significantly higher CBF in MCI compared to NC in the left and right precuneus, left middle temporal gyrus, and right calcarine gyrus. Significant lower CBF were found in AD compared with MCI in left and right cerebellum and right MCC, and significantly higher CBF in AD compared with MCI in left and right insula lobe, right thalamus, right calcarine gyrus, left and right thalamus, and right and left cerebellum.
Players', head coaches and medical personnel knowledge, understandings and perceptions of injury and injury prevention in elite-level women’s football in Ireland.
Authors: Horan Dan , Kelly Seamus , Hägglund Martin , Blake Catherine , Roe Mark , Delahunt Eamonn 
Published: September 2022

AbstractBackground To manage injuries effectively, players, head coaches and medical personnel need to have excellent knowledge, attitudes and behaviours in relation to the identification of risk factors for injury, the implementation of injury prevention initiatives, and the implementation of effective injury management strategies. Understanding the injury context whereby specific personal, environmental and societal factors can influence the implementation of injury prevention initiatives and injury management strategies is critical for player welfare. To date, no qualitative research investigating the context of injury has been undertaken in elite-level women’s football. The aim of our study was to explore the knowledge, attitudes and behaviours of players, head coaches and medical personnel in the Irish Women’s National League (WNL) to injury prevention and injury management. Methods We used qualitative research methods to explore the knowledge, attitudes and behaviours of players, head coaches and medical personnel in the Irish WNL to injury prevention and injury management. Semi-structured interviews were undertaken with 17 players, 8 medical personnel and 7 head coaches in the Irish WNL. This study is located within an interpretivist, constructivist research paradigm and interviews were analysed using thematic analysis. Results The participants had incomplete knowledge of common injuries in elite-level football, and many held beliefs about risk factors for injury, such as menstrual cycle stage, which lacked evidence to support them. Jumping and landing exercises were commonly used to reduce injury but evidence-based injury prevention exercises and programmes such as the Nordic curl, Copenhagen adduction and the FIFA 11 + were rarely mentioned. Overall, there was dissatisfaction amongst players with the medical and strength and conditioning (S & C) support with resultant inadequate communication between players, head coaches and medical personnel. Conclusion Poor quality and availability of medical and S & C support was considered to be a major obstacle in the effective implementation of injury risk reduction strategies and successful return-to-sport (RTS) practices. More original research is required in elite-level women’s football exploring injury risk factors, injury prevention initiatives and contextual RTS strategies so that players, head coaches and medical personnel can use evidence that is both up-to-date and specific to their environment.
Prevalence and predictors of long COVID among non-hospitalised adolescents and young adults: a prospective controlled cohort study
Authors: Wyller Vegard , Selvakumar Joel , Havdal Lise , Drevvatne Martin , Brodwall Elias , Berven Lise , Stiansen-Sonerud Tonje , Einvik Gunnar , Leegaard Truls , Tjade Trygve , Michelsen Annika , Mollnes Tom , Lund-Johansen Fridtjof , Holmøy Trygve , Zetterberg Henrik , Blennow Kaj , Sandler Carolina , Cvejic Erin , Lloyd Andrew 
Published: September 2022

Abstract
The prevalence and predictors of long COVID in young people remain unresolved. We aimed to determine the point prevalence of long COVID in non-hospitalised adolescents and young adults six months after the acute infection, to determine the risk of developing long COVID adjusted for possible confounders, and to explore a broad range of potential risk factors (prespecified outcomes). We conducted a prospective controlled cohort study of 404 SARS-CoV-2-positive and 105 SARS-CoV-2-negative non-hospitalised individuals aged 12–25 years (ClinicalTrial ID: NCT04686734). Data acquisition was completed February 2022. Assessments included pulmonary, cardiac and cognitive functional testing, biomarker analyses, and completion of a questionnaire, and were performed at inclusion (early convalescent stage) and six months follow-up. The WHO case definition of long COVID was applied. The point prevalence of long COVID at six months was 49% and 47% in the SARS-CoV-2-positive and negative group, respectively. SARS-CoV-2-positivity did not predict development of long COVID (relative risk 1.06, 95% CI 0.83 to 1.37). The main predictor was symptom severity at inclusion, which correlated strongly to personality traits. Low physical activity and loneliness were also predictive, while biological markers were not. In conlusion, our study aims were met, and the findings suggest that persistent symptoms were not driven by the infection, but were associated with psychosocial factors.
Knowledge and Practice of Healthcare Workers about Hand Hygiene in Khartoum Oncology Hospital, 2021
Authors: Magbol Mustafa Altayeb Ibrahim , Mohammed Saja Gariballa Ahmed , Hamad Nuha Mohamed Ahmed , Adam Alaa Salah Mohammed , Yagoub Elzubier Mohammed , Abdullah Ahmad Izzoddeen 
Published: September 2022

Abstract
Background: Hand hygiene is widely recognized as a simple way to prevent infection transmission to patients or among health care providers and adherence to its measures is associated with a significant reduction in mortality and morbidity. Despite this, many studies conclude that hand hygiene compliance is suboptimal. This study aims to assess compliance of healthcare workers to hand hygiene measures in Khartoum oncology hospital.
Method: A cross-sectional hospital-based descriptive study was conducted during the period from December 2021 to July 2022 on a sample of 109 health care workers [doctors and nurses]. Hand hygiene knowledge and practice of health care workers were measured using a structured, pretested, administered questionnaire, modified from the WHO standardized questionnaire for HH knowledge and observation technique with a checklist was used to collect data on the practice. The data is analyzed by frequency tables. The Chi-square test is used to determine associations among categorized variables. All statistical tests were considered significant when the p value was 0.005.
Result: Of the 109 participants, 56% had not received formal hand hygiene training in the last three years. 18.3% did not use alcohol for hand hygiene in their practice. Regarding participants' knowledge of the importance of hand hygiene, 97.2% considered it an important tool for infection prevention. Practice wise, 60% of participants did not wash their hands before touching the patients, while 20% of them used the same glove for more than one patient. A significant statistical association was found between the routine use of alcohol and receiving formal training in hand hygiene in the last three years (p-value 0.004).
Conclusion: The overall use of alcohol-based hand rub for hand hygiene was high, in spite of low training programs in the last three years. There is a huge shortage of soap and alcohol in working places. Developing a training program will help magnify the use of alcohol for hand hygiene.
Research on Multi-Scale Mechanical Properties of Paleosol Based on Freeze-Thaw Cycle
Authors: Bai Yang , Song Jia , Tian Jinyang , Zhou Zihao 
Published: September 2022

Abstract
In order to study the failure mechanism of palaeosoil landslide, taking a landslide body palaeosol in Yan'an as an example, scanning electron microscope (SEM), nuclear magnetic resonance (NMR) and conventional triaxial tests were performed on the palaeosol, which can get the particle composition and structure scanning results under cycle times, T2 spectrum distribution curve and stress-strain curve and can explore the correlation between the microstructure and macromechanical properties of palaeosols in landslides, and reveal the failure mechanism of palaeosoil landslides from multiple scales. The results show that with the increase in the number of freeze-thaw cycles, the micropores in the paleosol increased to 70.5% and then stabilized, while the small pores decreased to 18.4% and stabilized, the mesopores decreased to 7.5% and stabilized, and the large pores decreased to 3.6% and then tends to be stable, and the fractal dimension of pore shape distribution in paleosol gradually increases to 1.42 along the convex curve;The T2 spectrum distribution curve presents three small peaks in a stepped shape. The peak spectrum area with a relaxation time of 0.01ms-3.16ms is the largest, indicating that the proportion of small pores in the ancient soil is the largest; With the increase in the number of freeze-thaw cycles, the peak spectrum area corresponding to the smaller relaxation time continues to expand, indicating that the freeze-thaw cycle will damage the ancient soil structure and produce a large number of tiny pores. The confining pressure is higher, the lower the moisture content, the number of freeze-thaw cycles is fewer, and the greater the stress corresponding to its strain; the freeze-thaw cycle changes the stress-strain curve of paleosoil from a softened type to a hardened type, indicating that the original structure of the ancient soil is damaged due to the freeze-thaw cycle, and the new structure tends to become disordered and granular.