bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nontargeted Metabolomics Analysis of Oxacillin Resistance in Staphylococcus Aureus
Authors: Liu Jingjing , Qi Mingyang , Yuan Zichen , Wong Tin-Yan , Song Xiaofeng 
Published: July 2022

Abstract
BackgroundStaphylococcus aureus has acquired resistance to antibiotics in the long-term struggle against antibiotics. Treatment of Staphylococcus aureus infection has become more difficult. In this study, based on nontargeted metabolic figure printing technique, the metabolome of a pair of isogenic methicillin-susceptible and resistant Staphylococcus aureus (MSSA and MRSA) strains treated with the sublethal dose of oxacillin was characterize to investigate the mechanism of antibiotic resistance.ResultsMassive alternations of metabolite expression were observed in both MSSA and MRSA treated with oxacillin. The results of accurate mass and mass fragmentation analysis showed that 7 and 29 metabolites of MRSA and MSSA have changed significantly after oxacillin treatment. The dysregulated metabolites suggested that CoA and fatty acids could help Staphylococcus aureus survive under antibiotic stress. Metabolic pathways engaged in antibiotic resistance were discovered through pathway enrichment analysis. The enriched pathways suggested that DNA repairing and flavin biosynthesis are universal pathways to help MSSA and MRSA survive under antibiotic stress. Compared with MSSA, MRSA systematically and effectively fight against oxacillin through precisely controlling energy producing, PBP2a substrate biosynthesis and antioxidant function. ConclusionsCoenzyme A and fatty acids help both MSSA and MRSA survive under the antibiotic stress. MSSA was susceptible to oxacillin and was forced to response. On the contrary, MRSA systematically and effectively fight against oxacillin. The different metabolome responses of MSSA and MRSA provide us with new insights into how Staphylococcus aureus develops antibiotics resistance.
Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis
Authors: Alymenko M. A. , Valiev R. Sh. , Polonikov A. V. , Golubeva T. N. , Vasilevskaya A. P. , Miroshnik E. V. 
Published: July 2022

The objective: to investigate the relationship of polymorphic variants of genes of xenobiotic biotransformation metabolism enzymes (NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)), GSTM1 (E/D), GSTT1 (E/D) with the risk of pulmonary tuberculosis.Subjects and Methods. Within the framework of this study, a population sample of unrelated 1081 individuals of Slavic nationalities (mainly Russians) living in the territory of Kursk Oblast was used.Results. The del/del (D/D) GSTM1 genotype was associated with an increased risk of developing tuberculosis, while carrying the del/del (D/D) GSTT1 genotype was associated with a lower risk of developing the disease. Polymorphism 3435T>C ABCB1 (TC genotype) was associated with increased susceptibility to pulmonary tuberculosis in the codominization model, while TT+TC genotypes had the same association in the dominance model.
Pair production of charged IDM scalars at high energy CLIC
Authors: Klamka Jan 
Published: July 2022

The Compact Linear Collider (CLIC) was proposed as the next
energy-frontier infrastructure at CERN, to study
e^++e^-−
collisions at three centre-of-mass energy stages: 380,GeV, 1.5,TeV and
3,TeV. The main goal of its high-energy stages is to search for the new
physics beyond the Standard Model (SM). The Inert Doublet Model (IDM) is
one of the simplest SM extensions and introduces four new scalar
particles: H^\pm±,
A and H; the lightest, H, is stable and hence a natural dark matter (DM)
candidate. A set of benchmark points is considered, which are consistent
with current theoretical and experimental constraints and promise
detectable signals at future colliders.Prospects for observing pair-production of the IDM scalars at CLIC
were previously studied using signatures with two leptons in the final
state. In the current study, discovery reach for the IDM charged scalar
pair-production is considered for the semi-leptonic final state at the
two high-energy CLIC stages. Full simulation analysis, based on the
current CLIC detector model, is presented for five selected IDM
scenarios. Results are then extended to the larger set of benchmarks
using the Delphes fast simulation framework. The CLIC detector model for
Delphes has been modified to take pile-up contribution from the
beam-induced \gamma\gammaγγ
interactions into account, which is crucial for the presented analysis.
Results of the study indicate that heavy, charged IDM scalars can be
discovered at CLIC for most of the proposed benchmark scenarios, with
very high statistical significance.
Recuperación feminista de la categoría de ley natural
Authors: Di Renzo Gabriela 
Published: July 2022

El estudio plantea una recuperación de la categoría de ley natural, desde los aportes de la teología feminista. La problemática de la ley natural que estructura y fundamenta la ética teológica del magisterio católico, se fue entretejiendo en el tiempo y su gran sistematizador fue Santo Tomas De Aquino. La teología feminista, surgida de las teorías feministas sustenta como principio crítico la promoción de la plena humanidad de las mujeres y asume que los textos y las tradiciones de la comunidad cristiana o las marcas de su recepción a lo largo de la historia, funcionan a partir de una concepción errónea de la mujer. Esto ha configurado para ellas un ethos a partir de una visión estática y esencialista de su naturaleza. La teología feminista es consciente de la necesidad de reflexionar a partir de una antropología igualitaria que incluya y haga partícipes a las mujeres del bien humano de la misma manera que a los varones, y a la vez permita visualizar las diferentes maneras en que varones y mujeres experimentan sus vidas. Esta reflexión encarnada sobre los bienes a los que estamos dirigidos y el descubrimiento de los medios necesarios para lograrlos integra la comprensión de la ley natural
Del ente en el mundo al mundo en el ente. Introducción al concepto cosmológico de mundo de Eugen Fink
Authors: Garrido-Maturano Ángel Enrique 
Published: July 2022

El artículo introduce la noción cosmológica de mundo de Eugen Fink. Para ello la distingue primero del mundo concebido como recipiente a partir del “ser en” el mundo de los entes cósicos. Luego la diferencia del mundo concebido como existenciario a partir del “ser en” el mundo del hombre. Posteriormente explicita el mundo cosmológico como unicidad, espacio-tiempo y movimiento ontogénico de individuación y aparición. La explicitación se orienta a poner de manifiesto el carácter originario del mundo cosmológico desde el punto de vista trascendental. Finalmente analiza el fenómeno fundamental del juego como modelo operativo que reproduce el imperar del mundo en el ámbito intramundano y, sobre la base del análisis del juego, muestra en qué medida la noción cosmológica de mundo de Fink puede representar un punto común en el que se encuentren las cosmologías científicas y la visión religiosa del mundo.
PENGARUH PUSH PULL MOORING TERHADAP SWITCHING INTENTION PADA PENGGUNA APLIKASI VIDEO ON DEMAND DI MASA PANDEMI COVID-19
Authors: Yusuf Heri Gunawan , Ratnasari Asti 
Published: July 2022

<p>Pandemi covid-19 memberikan dampak buruk bagi Negara Indonesia. Pemerintah menetapkan aturan-aturan kesehatan yang bertujuan untuk mencegah penularan yang semakin meluas. Pada penelitian ini peneliti akan mengidentifikasi faktor yang mempengaruhi niat beralih pengunjung bioskop khususnya bagi Mahasiswa Universitas Alma Ata menggunakan aplikasi <em>video on demand</em> menggunakan metode <em>Switching Intention. </em>Teori <em>Push Pull Mooring </em>digunakan untuk mengetahui faktor yang mempengaruhi niat individu untuk beralih menggunakan layanan <em>video on demand</em>. <em>Push factor</em> yaitu faktor pendorong dari penyedia jasa lama (faktor negatif). <em>Pull factor</em> yaitu faktor penarik yang berasal dari penyedia jasa baru yaitu aplikasi <em>video on demand</em> (faktor positif) dan <em>Mooring factor</em> merupakan faktor penghambat yang dapat memperkuat atau memperlemah niat individu untuk berpindah. Populasi yang ditetapkan pada penelitian ini adalah mahasiswa aktif Universitas Alma Ata tahun angkatan 2018-2020 yang menggunakan aplikasi <em>video on demand</em>. Instrumen penelitian ini menggunakan kuesioner yang dibagikan kepada responden secara <em>online</em> menggunakan <em>google form</em>. Jumlah responden yang digunakan dalam penelitian sebanyak 100 yang dipilih berdasarkan dari waktu pengisi kuesioner oleh responden. Hasil yang diperoleh dalam penelitian ini dapat disimpulkan bahwa empat (4) hipotesis berpengaruh secara signifikan dan diterima, empat (4) hipotesis lainnya tidak signifikan dan ditolak. Variabel yang secara signifikan berpengaruh positif yaitu <em>social influence</em> terhadap <em>trust</em>, variabel <em>subjective norm</em> terhadap <em>switching intention</em>, <em>system quality</em> terhadap <em>user satisfaction</em>, <em>trust</em> terhadap <em>switching intention</em>.</p>
Digital Device Exposure and Cognition Levels of Children in Low- and Middle-Income Countries: Cross-sectional Study in Cambodia
Authors: Kim Hye Hyeon , Lee JooHyun , Kim Ho Heon , Hwang Sangho , Yi Ilcheong , Kao Sambath , Kim DooRa , Sohn Hyuk-Sang , Kim Joohye , Choi Yejin , Yoon Sangchul , Park Yu Rang 
Published: July 2022

Background
Policy makers and practitioners in low- and middle-income countries (LMICs) are increasingly focusing on the effectiveness of digital devices in the delivery of medical and educational services to children under resource constraints. It is widely known that digital literacy can be fostered through exposure to and education regarding digital devices, which can improve children’s academic performance as well as their search and communication skills in the digital era. However, the correlation between the cognitive function of children and exposure and intensity of the exposure to digital devices has rarely been studied, and the association between digital device exposure and the socioeconomic characteristics and cognitive development of children in LMICs is unknown.

Objective
This study examines the association among exposure to digital devices, socioeconomic status, and cognitive function in children aged 3 to 9 years in Cambodia.

Methods
We used a survey of 232 children that gathered data on familiarity with digital devices, demographic characteristics, and socioeconomic status, as well as a Cambridge Neuropsychological Test Automated Battery test for cognitive function, to examine the association between possible barriers and factors that may influence the cognitive function of children in 2 Cambodian schools from April 22, 2019, to May 4, 2019. A comparative analysis was performed with and without digital exposure, and an association analysis was performed among the variables from the survey and cognitive function.

Results
Significant differences were observed in demographic and socioeconomic characteristics such as school location, family type, and family income according to digital device exposure. The results of the Cambridge Neuropsychological Test Automated Battery tests, except for 1 test related to executive function, indicated no significant differences (P>.05) between group A and group B or among the 4 subgroups. Pretest digital device experience and amount of time spent using digital devices during the test had no significant impacts on the cognitive development of the children. Conversely, the multivariate analyses showed that cognitive function was associated with educational expenses per child, school (location), family type, and family income.

Conclusions
These results provide evidence to policy makers and practitioners on the importance of improving socioeconomic conditions, leading to investment in education by implementing programs for children’s cognitive development through digital devices in LMICs.
Multimodal Assessment of Schizophrenia and Depression Utilizing Video, Acoustic, Locomotor, Electroencephalographic, and Heart Rate Technology: Protocol for an Observational Study
Authors: Cotes Robert O , Boazak Mina , Griner Emily , Jiang Zifan , Kim Bona , Bremer Whitney , Seyedi Salman , Bahrami Rad Ali , Clifford Gari D 
Published: July 2022

BackgroundCurrent standards of psychiatric assessment and diagnostic evaluation rely primarily on the clinical subjective interpretation of a patient’s outward manifestations of their internal state. While psychometric tools can help to evaluate these behaviors more systematically, the tools still rely on the clinician’s interpretation of what are frequently nuanced speech and behavior patterns. With advances in computing power, increased availability of clinical data, and improving resolution of recording and sensor hardware (including acoustic, video, accelerometer, infrared, and other modalities), researchers have begun to demonstrate the feasibility of cutting-edge technologies in aiding the assessment of psychiatric disorders.ObjectiveWe present a research protocol that utilizes facial expression, eye gaze, voice and speech, locomotor, heart rate, and electroencephalography monitoring to assess schizophrenia symptoms and to distinguish patients with schizophrenia from those with other psychiatric disorders and control subjects.MethodsWe plan to recruit three outpatient groups: (1) 50 patients with schizophrenia, (2) 50 patients with unipolar major depressive disorder, and (3) 50 individuals with no psychiatric history. Using an internally developed semistructured interview, psychometrically validated clinical outcome measures, and a multimodal sensing system utilizing video, acoustic, actigraphic, heart rate, and electroencephalographic sensors, we aim to evaluate the system’s capacity in classifying subjects (schizophrenia, depression, or control), to evaluate the system’s sensitivity to within-group symptom severity, and to determine if such a system can further classify variations in disorder subtypes.ResultsData collection began in July 2020 and is expected to continue through December 2022.ConclusionsIf successful, this study will help advance current progress in developing state-of-the-art technology to aid clinical psychiatric assessment and treatment. If our findings suggest that these technologies are capable of resolving diagnoses and symptoms to the level of current psychometric testing and clinician judgment, we would be among the first to develop a system that can eventually be used by clinicians to more objectively diagnose and assess schizophrenia and depression with the possibility of less risk of bias. Such a tool has the potential to improve accessibility to care; to aid clinicians in objectively evaluating diagnoses, severity of symptoms, and treatment efficacy through time; and to reduce treatment-related morbidity.International Registered Report Identifier (IRRID)DERR1-10.2196/36417
Audit Sistem Informasi Inventory Pada PT. DP Utan Kayu Dengan Framework Cobit 4.1
Authors: Hudin Jamal Maulana , Anggraeny Nia , Prayudi Dicki 
Published: July 2022

Penelitian ini akan Membahas bagaimana audit sistem informasi inventory pada Domino’s Pizza Utan Kayu menggunakan COBIT 4 sub domain PO, Al, DS, ME. Pengambilan data dilakukan menggunakan wawancara dan kuisioner. Pertanyaan dari kuisioner dibuat berdasarkan aktivitas pada cobit 4.1, yang disebarkan pada karyawan yang ada di Domino’s Pizza. Hasil penelitian menunjukkan bahwa hasil pengelolaan kuesioner mendapatkan nilai rata-rata untuk domain PO, ME, AI, DS adalah 3,23 dari rentang 0 – 5 yang artinya penerapan sistem inventory pada Domino’s Pizza telah dilakukan tetapi masih memerlukan proses tata kelola TI secara rutin dan pada hasil penelitian ini ditemukan bahwa pada domain PO1 dan ME 2 di Domino’s Pizza telah sesuai ekspektasi yaitu pada level 4 Manage and Measurable tetapi domain lainnya masih menduduki level 3 yaitu Defined Process.
Perancangan Bangun Aplikasi Pengenalan Budaya Lombok Menggunakan Augmented Reality Berbasis Android
Authors: Hamzaturrazak Multohadi , Huasniah Lailatul , Wibowo Hardianto 
Published: July 2022

Teknologi yang semakin berkembang membuat kebutuhan kita akan sebuah teknologi semakin meningkat dan membuatnya menjadi efisien, akan tetapi dampak yang dihasilkan dari semua ini sangatlah besar bagi kebudayaan yang ada di Indonesia, karena menyebabkan kurangnya minat terhadap kebudayaan yang memiliki tradisi yang sangat tradisional, maupun begitu teknologi juga memiliki bagian positive yang mampu meningkatkan minat akan kebudayaan, seperti game kebudayaan, ataupun aplikasi dokumentasi kebudayaan, dan salah satunya adalah yang akan dibuat peneliti yaitu membuat AR tentang kebudayaan Lombok. AR (augmented reality) merupakan teknologi yang menggabungkan benda maya kedalam sebuah lingkungan nyata secara langsung. Aplikasi ini akan dibangun menggunakan unity dan sedangkan untuk obyeknya akan dibangun menggunakan blender, tidak lupa membuat marker sebagai media untuk menampilkan obyek. Aplikasi ini akan digunakan pada smartphone agar mudah digunakan. Proses dalam pengujiannya akan terdiri dari dua tahap yaitu pengujian kamera dan pengujian lapangan apakah aplikasi ini diterima oleh masyarakat atau tidak.
Evaluasi Usability Menggunakan Metode SUS (System Usability Scale) Serta Menentukan Korelasi Dengan Tingkat Kelulusan Mahasiswa (Studi Kasus : LMS Universitas Muhammadiyah Malang)
Authors: Sahara Nur Riyan , Marthasari Gita Indah , Wiyono Briansyah Setio 
Published: July 2022

Akhir-akhir ini dunia dihebohkan dengan adanya virus baru yang belum diketahui penyebabnya, virus ini biasa disebut covid-19. Dengan adanya virus baru yang mematikan ini Pemerintah menghimbau untuk melaksanakan kegiatan pembelajaran secara daring dengan menggunakan teknologi dan jaringan internet. Universitas Muhammadiyah Malang telah mengembangkan model pembelajaran berbasis e-learning dengan memanfaatkan teknologi dan jaringan internet. Salah satu platform e-learning yang digunakan oleh kampus UMM yaitu Learning Management System (LMS) UMM. Didalam website LMS UMM, tersedia berbagai fitur yang di didalamnya dapat diakses oleh dosen dan mahasiswanya sehingga mahasiswa dapat berdiskusi dengan pengajar tentang materi yang sudah di sampaikan oleh dosen di LMS. Suatu sistem dapat dikatakan berhasil jika sistem tersebut dapat digunakan dengan mudah oleh pengguna atau user, hal ini disebut dengan usability. Usability adalah sebuah analisa kualitatif yang menentukan seberapa mudah User menggunakan antarmuka suatu aplikasi, aplikasi dapat dikatakan usable apabila fungsinya dapat dijalankan secara efektif, efisien, dan memuaskan.Maka dari itu penelitian ini bertujuan untuk mengevaluasi sejauh mana sistem LMS UMM dapat digunakan dengan baik oleh user dengan mendapatkan nilai tingkat usability dari sistem. Metode yang digunakan yaitu SUS (System Usability Scale), SUS merupakan salah satu metode yang digunakan dalam mengukur tingkat Usability pada suatu aplikasi atau perangkat lunak. System Usability Scale (SUS) juga merupakan salah satu instrumen evaluasi yang digunakan untuk melihat usability dari sebuah produk perangkat lunak. Selain itu penelitian ini juga bertujuan untuk menentukan apakah ada korelasi antara tingkat usability dari sistem LMS dengan tingkat kelulusan mahasiswa yang menggunakan sistem LMS UMM ini.
Artificial Sweeteners Alter Early Vitelline Vessel Development in Chick Embryo
Authors: Fatma M.S.N. Al-Qudsi  , Amna Al-Rashdi  
Published: July 2022

During early embryonic development, nutrients are transferred to the embryo via vitelline vessels. Disorders that affect vitelline vessel development lead to embryonic lethality or vascular diseases. In recent years, the use of artificial sweeteners has increased and become more widespread, however the potential effects of these compounds on embryonic development remain poorly understood and controversial. This study aimed to establish the effect of commercial artificial sweeteners on early vitelline vessel development in chick embryos. The commercial artificial sweetener used in this study was a mixture of aspartame and acesulfame k. Fertile chicken eggs were divided into four groups: control, sham, and two treated groups that were injected in the air chamber before incubation with 50mg/kg or 100mg/ kg sweetener by body weight. The eggs were then incubated under normal incubation conditions. Embryos were extracted and photographed on days 3 and 4 of incubation, then vitelline vessel measurements were taken (length and width of the vitelline vessels, right and left angles, and number of branches). VEGF concentration within the area vasculosa of 3-day embryos was measured by ELISA. Low- and high- treated embryos showed abnormal vitelline vessel development at 3 and 4 days post-incubation. Some vessels were enlarged while others displayed atrophy. The pattern of branching was also altered compared to controls, and some vessels had hemorrhage. The concentration of VEGF was lower in the treated groups compared to that observed in the control group. This study revealed an association between artificial sweeteners and abnormal vitelline vessel development. These findings could have broad potential implications for human health, as this study used commercial artificial sweeteners that are commonly available in consumer markets.
Genotoxic and Antitumor Activity of Pollen Grains against Prostate Cancer Cell Line
Authors: Magdah Ganash  
Published: July 2022

Since the use of engineered antioxidants and antitumor is under investigation, inferable from its likely poisonousness, scientists have deflected their thoughtfulness regarding the quest for characteristic sources to meet the human medication and diet requests. Therefore the study aimed to evaluate the antitumor and antioxidant activities of maize pollen grains against the Prostate Cancer Cell (Pc3) line. Maize pollen grains were collected by Bee through a pollen trap, and then subjected for flavonoids and alkaloids analysis by HPLC method. an in vitro assays, were used to test the antitumor properties, against Pc3 cells. Furthermore, its antioxidant potential was also evaluated by DPPH. The detected flavonoids were identified to be quercetin, luteolin kaempferol, rutin, apigenin and naringin and the alkaloids were quinolone, hydroxyindolenine and conofoline. The antitumor efficacy of pollen grains extract increased with concentration and reached to 94.92 % that similar to the toxicity % of adriamycin at 1000 µg/mL, however, the IC50 (339.81 µg) of pollen grains extract was highest than IC50 (58.07 µg) of adriamycin. At 500 µg/mL of pollen grains extract, morphological changes of Pc3 were recorded. These changes deformed more at 1000 µg/mL. DPPH scavenging activity was found to be 92.26 % at 1280 µg/mL of pollen grains extracted with IC50 425.4 µg/mL compared with IC50 (13.9 µg/mL) of the ascorbic acid. DNA fragmentation and quantitative RT-PCR examinations of Bax and Bcl-2 genes demonstrated that pollen grains extract induced cellular apoptosis of Pc3 cells. This study concluded that the maize pollen grains may applied as natural safe source for inhibit Pc3 Cells proliferation as well as applied as antioxidant.