bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated primary health care services in two protracted refugee camp settings at the Thai–Myanmar border 2000–2018: trends on mortality and incidence of infectious diseases
Authors: Mohr Oliver , Benner Marie T. , Sansoenboon Ammarat , Kaloy Wiphan , McGready Rose , Carrara Verena I. 
Published: March 2022

AbstractAim:This study aimed to assess the health outcome of four epidemic-prone infectious diseases, in the context of a Primary Health Care project implemented in a protracted refugee setting along the Thai–Myanmar border.Background:Refugees settled at the Thai–Myanmar border are fully dependent on support for health services, shelter, food, education, water, and sanitation. The Non-Governmental Organization Malteser International developed an integrated Primary Health Care program in close cooperation with trained camp residents over 25 years in the two settlements under its supervision. The project has been funded by the European Commission Civil Protection and Humanitarian Aid Operations (DG ECHO).Methods:This was a retrospective primary health care project evaluation. All-cause mortality; morbidity trends in malaria, lower respiratory tract infections (LRTIs), watery diarrhea, and dysentery; and health service utilization covering a time span of 18 years were assessed. Programmatic changes in the Primary Health Care (PHC) project and events with a potential effect on health of the target population were examined.Findings:Despite the continuous drain of trained health care workers, the volatile influx of refugees, and the isolated location of the two camps, the initial basic curative health care developed into an integrated and comprehensive PHC project including a SPHERE-compliant water, sanitation, and hygiene program. Malaria, LRTIs, watery diarrhea, and dysentery morbidity dropped twelve, three, two, and fivefold, respectively, over the 18-year period evaluated while the health services utilization dropped from 7.1 to 2.9 consultations per refugee/year. The international community may face situations where integration of refugees into the health services of the host country is not possible. In such a context, integrated and evidence-based PHC adequately funded and implemented by one health agency is an effective and relevant approach to reduce the infectious diseases burden under the constraints of semipermanent living conditions.
The Role of Procedural Justice in Policing
Authors: Pryce Daniel K. , Whitaker Ingrid Phillips 
Published: March 2022

AbstractEmpirical studies have pointed to the increasing importance of procedural justice as a tool for improving the relationship between the police and local communities. The mediating role of procedural justice continues to be embraced by scholars, practitioners, and community members; as a result, we examine in the present study African Americans’ attitudes toward the police via the interpretive lens of procedural justice policing. Using procedural justice questions found in the social-psychology literature, we interviewed seventy-seven African Americans in Durham, NC, to assess their views about the U.S. police. Our results point to the following for improving the relationship between the police and African Americans: respect for African Americans by police, police fairness in the African American community, and increased and improved interaction between police and African Americans. Notably, these findings spanned three distinct educational and socioeconomic spectrums. The implications of our findings for community relations, public policy, and future research are discussed.
Global regulatory competition on digital rights and data protection: A novel and contractive form of Eurocentrism?
Authors: Çapar Gürkan 
Published: March 2022

AbstractGlobal regulatory competition is a recent phenomenon that confronts us in various different fields, ranging from food and chemical safety to climate change, and animal welfare to environmental law. The digital economy is not immune to this trend, and it seems highly unlikely that this will soon come to an end when we consider the radical differences between the European Union and the United States with respect to the importance they assign to the right to privacy and the right to freedom of speech. Nevertheless, despite their differences in content, it can be contended that they both tend to disregard the interest of others even though they have enough resources at their disposal to take them seriously. This becomes visible when the recent case law of the CJEU and the recent regulations such as the GDPR and the US CLOUD Act are taken into account. Their similar attitude to regulating for the globe raises the question of whether we are confronted with a new type of Eurocentrism, which is more contracted and introverted than the previous expansionist version. The article argues that unilateralism should be a selfless one and that it should necessarily consider outsiders if it is to acquire legitimacy.
Ocean Sound Propagation in a Changing Climate: Global Sound Speed Changes and Identification of Acoustic Hotspots
Authors: Affatati Alice , Scaini Chiara , Salon Stefano 
Published: March 2022

AbstractClimate change is a relevant threat on a global scale, leading to impacts on ecosystems and ocean biodiversity. A considerable fraction of marine life depends on sound. Marine mammals, in particular, exploit sound in all aspects of their life, including feeding and mating. This work explores the impact of climate change in sound propagation by computing the three‐dimensional global field of underwater sound speed. The computation was performed based on present conditions (2006–2016) and a “business‐as‐usual” future climate scenario (Representative Concentration Pathway 8.5), identifying two “acoustic hotspots” where larger sound speed variations are expected. Our results indicate that the identified acoustic hotspots will present substantial climate‐change‐induced sound speed variations toward the end of the century, potentially affecting the vital activities of species in the areas. Evidence is provided of the impact of such variation on underwater sound transmission. As an example of a species impacted by underwater transmission, we considered one marine mammal endangered species, the North Atlantic right whale (Eubalaena glacialis), in the northwestern Atlantic Ocean. To the best of our knowledge, this is the first global‐scale data set of climate‐induced sound speed changes expected under a future scenario. This study provides a starting point for policies oriented research to promote the conservation of marine ecosystems and, in particular, endangered marine mammals.
A Decreasing Trend of Nitrous Oxide Emissions From California Cropland From 2000 to 2015
Authors: Deng Jia , Guo Lei , Salas William , Ingraham Pete , Charrier‐Klobas Jessica G. , Frolking Steve , Li Changsheng 
Published: March 2022

AbstractMitigation of greenhouse gas emissions from agriculture requires an understanding of spatial‐temporal dynamics of nitrous oxide (N2O) emissions. Process‐based models can quantify N2O emissions from agricultural soils but have rarely been applied to regions with highly diverse agriculture. In this study, a process‐based biogeochemical model, DeNitrification‐DeComposition (DNDC), was applied to quantify spatial‐temporal dynamics of direct N2O emissions from California cropland employing a wide range of cropping systems. DNDC simulated direct N2O emissions from nitrogen (N) inputs through applications of synthetic fertilizers and crop residues during 2000–2015 by linking the model with a spatial‐temporal differentiated database containing data on weather, crop areas, soil properties, and management. Simulated direct N2O emissions ranged from 3,830 to 7,875 tonnes N2O‐N yr−1, representing 0.73%–1.21% of the N inputs. N2O emission rates were higher for hay and field crops and lower for orchard and vineyard. State cropland total N2O emissions showed a decreasing trend primarily driven by reductions of cropland area and N inputs, the trend toward growing more orchard, and changes in irrigation. Annual direct N2O emissions declined by 47% from 2000 to 2015. Simulations showed N2O emission variations could be explained not only by cropland area and N fertilizer inputs but also climate, soil properties, and management besides N fertilization. The detailed spatial‐temporal emission dynamics and driving factors provide knowledge toward effective N2O mitigation and highlight the importance of coupling process‐based models with high‐resolution data for characterizing the spatial‐temporal variability of N2O emissions in regions with diverse croplands.
A Statistical Study of Poleward Traveling Ionospheric Disturbances Over the African and American Sectors During Geomagnetic Storms
Authors: Habarulema John Bosco , Thaganyana Golekamang P. , Katamzi‐Joseph Zama T. , Yizengaw Endawoke , Moldwin Mark B. , Ngwira Chigomezyo M. 
Published: March 2022

AbstractWe present statistical results of traveling ionospheric disturbances (TIDs) with origin near the geomagnetic equator during geomagnetic storms that occurred within the period of 2010–2018. Based on storm criteria of Kp > 4 and Dst ≤ −50 nT, we have analyzed total electron content perturbations derived from Global Navigational Satellite Systems observations within a latitude range of 40°S–60°N and longitude ranges of 20°–40°E and 50°–70°W representing the African and American sectors. Although the northern hemispheric part of the African sector has limited data coverage, results show that the launched TIDs do not exceed the latitudinal distance of 20°–25° from their origin during the analyzed period. A statistically similar result is observed over the American sector with launched poleward TIDs constrained largely within ±20°–30° around the geomagnetic equator. Where data are available, majority of these cases are linked to changes in ionospheric electrodynamics, especially the enhancement of equatorial electrojet (EEJ), although there are other observations that are not explained by EEJ variability. This indicates that there may be other physical mechanisms that play a role in launching TIDs at the geomagnetic equator during disturbed conditions. An important result is that large‐scale and medium‐scale TIDs have been found to occur predominantly during the main and recovery phases of geomagnetic storms, respectively, at least over the African sector.
Multi‐Scale Density Structures in the Plasmaspheric Plume During a Geomagnetic Storm
Authors: Nishimura Y. , Goldstein J. , Martinis C. , Ma Q. , Li W. , Zhang S. R. , Coster A. J. , Mrak S. , Semeter J. L. , Nishitani N. , Ruohoniemi J. M. , Shepherd S. G. 
Published: March 2022

AbstractEvolution of large‐scale and fine‐scale plasmaspheric plume density structures was examined using space‐ground coordinated observations of a plume during the 7–8 September 2015 storm. The large‐scale plasmaspheric plume density at Van Allen Probes A was roughly proportional to the total electron content (TEC) along the satellite footprint, indicating that TEC distribution represents the large‐scale plume density distribution in the magnetosphere. The plasmaspheric plume contained fine‐scale density structures and subauroral polarization streams (SAPS) velocity fluctuations. High‐resolution TEC data support the interpretation that the fine‐scale plume structures were blobs with ∼300 km size and ∼500–800 m/s in the ionosphere (∼3,000 km size and ∼5–8 km/s speed in the magnetosphere), emerging at the plume base and drifting to the plume. The short‐baseline Global Navigation Satellite System receivers detected smaller‐scale (∼10 km in the ionosphere, ∼100 km in the magnetosphere) TEC gradients and their sunward drift. Fine‐scale density structures were associated with enhanced phase scintillation index. Velocity fluctuations were found to be spatial structures of fine‐scale SAPS flows that drifted sunward with density irregularities down to ∼10 s of meter‐scale. Fine‐scale density structures followed a power law with a slope of ∼−5/3, and smaller‐scale density structures developed slower than the larger‐scale structures. We suggest that turbulent SAPS flows created fine‐scale density structures and their cascading to smaller scales. We also found that the plume fine‐scale density structures were associated with whistler‐mode intensity modulation, and localized electron precipitation in the plume. Structured precipitation in the plume may contribute to ionospheric heating, SAPS velocity reduction, and conductance enhancements.
Strong Margin Influence on the Arctic Ocean Barium Cycle Revealed by Pan‐Arctic Synthesis
Authors: Whitmore Laura M. , Shiller Alan M. , Horner Tristan J. , Xiang Yang , Auro Maureen E. , Bauch Dorothea , Dehairs Frank , Lam Phoebe J. , Li Jingxuan , Maldonado Maria T. , Mears Chantal , Newton Robert , Pasqualini Angelica , Planquette Hélène , Rember Robert , Thomas Helmuth 
Published: March 2022

AbstractEarly studies revealed relationships between barium (Ba), particulate organic carbon and silicate, suggesting applications for Ba as a paleoproductivity tracer and as a tracer of modern ocean circulation. But, what controls the distribution of barium (Ba) in the oceans? Here, we investigated the Arctic Ocean Ba cycle through a one‐of‐a‐kind data set containing dissolved (dBa), particulate (pBa), and stable isotope Ba ratio (δ138Ba) data from four Arctic GEOTRACES expeditions conducted in 2015. We hypothesized that margins would be a substantial source of Ba to the Arctic Ocean water column. The dBa, pBa, and δ138Ba distributions all suggest significant modification of inflowing Pacific seawater over the shelves, and the dBa mass balance implies that ∼50% of the dBa inventory (upper 500 m of the Arctic water column) was supplied by nonconservative inputs. Calculated areal dBa fluxes are up to 10 μmol m−2 day−1 on the margin, which is comparable to fluxes described in other regions. Applying this approach to dBa data from the 1994 Arctic Ocean Survey yields similar results. The Canadian Arctic Archipelago did not appear to have a similar margin source; rather, the dBa distribution in this section is consistent with mixing of Arctic Ocean‐derived waters and Baffin Bay‐derived waters. Although we lack enough information to identify the specifics of the shelf sediment Ba source, we suspect that a sedimentary remineralization and terrigenous sources (e.g., submarine groundwater discharge or fluvial particles) are contributors.
The Annual Salinity Cycle of the Denmark Strait Overflow
Authors: Opher J. G. , Brearley J. A. , Dye S. R. , Pickart R. S. , Renfrew I. A. , Harden B. E. , Meredith M. P. 
Published: March 2022

AbstractThe Denmark Strait Overflow (DSO) is an important source of dense water input to the deep limb of the Atlantic Meridional Overturning Circulation (AMOC). It is fed by separate currents from the north that advect dense water masses formed in the Nordic Seas and Arctic Ocean which then converge at Denmark Strait. Here we identify an annual salinity cycle of the DSO, characterized by freshening in winter and spring. The freshening is linked to freshening of the Shelfbreak East Greenland Current in the Blosseville Basin north of the Denmark Strait. We demonstrate that the East Greenland Current advects fresh pycnocline water above the recirculating Atlantic Water, which forms a low salinity lid for the overflow in Denmark Strait and in the Irminger Basin. This concept is supported by intensified freshening of the DSO in lighter density classes on the Greenland side of the overflow. The salinity of the DSO in the Irminger Basin is significantly correlated with northerly/northeasterly winds in the Blosseville Basin at a lag of 3–4 months, consistent with estimated transit times. This suggests that wind driven variability of DSO source water exerts an important influence on the salinity variability of the downstream DSO, and hence the composition of the deep limb of the AMOC.
Measurement and Analysis of the Microphysical Properties of Arctic Precipitation Showing Frequent Occurrence of Riming
Authors: Fitch Kyle E. , Garrett Timothy J. 
Published: March 2022

AbstractDetailed ground‐based observations of snow are scarce in remote regions, such as the Arctic. Here, Multi‐Angle Snowflake Camera measurements of over 55,000 solid hydrometeors—obtained during a two‐year period from August 2016 to August 2018 at Oliktok Point, Alaska—are analyzed and compared to similar measurements from an earlier experiment at Alta, Utah. In general, distributions of hydrometeor fall speed, fall orientation, aspect ratio, flatness, and complexity (i.e., riming degree) were observed to be very similar between the two locations, except that Arctic hydrometeors tended to be smaller. In total, the slope parameter defining a negative exponential of the size distribution was approximately 50% steeper in the Arctic as at Alta. Sixty‐six percent of particles were observed to be rimed or moderately rimed with some suggestion that riming is favored by weak boundary layer stability. On average, the fall speed of rimed particles was not notably different from aggregates. However, graupel density and fall speed increase as cloud temperatures approach the melting point.
Characterizing Sediment Flux of Deforming Glacier Beds
Authors: Hansen D. D. , Zoet L. K. 
Published: March 2022

AbstractDeformation of subglacial sediment during basal slip shapes the beds of many fast‐flowing glaciers and ice streams. The resultant sediment flux impacts glacier dynamics and rates of subglacial erosion over a range of timescales, but its fundamental dependencies are not well understood. Using a cryogenic ring shear device, we conducted experiments to investigate the effects of both effective stress and slip speed on rates of till transport. Sediment fluxes were computed using digital image correlation from a photographic time series of the till bed. We find a near‐linear relationship between sediment flux and slip speed, but a non‐monotonic, double‐valued dependency of sediment flux on effective stress. Deformation primarily occurred in a thin shear band near the ice sole, the thickness of which could vary with both parameters. Coupling between ice and till increased at higher slip speeds and effective stresses and scaled the magnitude of the flow profile.
Diagnosing the Thickness‐Weighted Averaged Eddy‐Mean Flow Interaction From an Eddying North Atlantic Ensemble: The Eliassen‐Palm Flux
Authors: Uchida Takaya , Jamet Quentin , Dewar William K. , Le Sommer Julien , Penduff Thierry , Balwada Dhruv 
Published: March 2022

AbstractThe thickness‐weighted average (TWA) framework, which treats the residual‐mean flow as the prognostic variable, provides a clear theoretical formulation of the eddy feedback onto the residual‐mean flow. The averaging operator involved in the TWA framework, although in theory being an ensemble mean, in practice has often been approximated by a temporal mean. Here, we analyze an ensemble of North Atlantic simulations at mesoscale‐permitting resolution (1/12°). We therefore recognize means and eddies in terms of ensemble means and fluctuations about those means. The ensemble dimension being orthogonal to the temporal and spatial dimensions negates the necessity for an arbitrary temporal or spatial scale in defining the eddies. Eddy‐mean flow feedbacks are encapsulated in the Eliassen‐Palm (E‐P) flux tensor and its convergence indicates that eddy momentum fluxes dominate in the separated Gulf Stream. The eddies can be interpreted to contribute to the zonal meandering of the Gulf Stream and a northward migration of it in the meridional direction. Downstream of the separated Gulf Stream in the North Atlantic Current region, the interfacial form stress convergence becomes leading order in the E‐P flux convergence.
Little Influence of Asian Anthropogenic Aerosols on Summer Temperature in Central East Asia Since 1960
Authors: Hua Wenjian , Dai Aiguo , Chen Haishan 
Published: March 2022

AbstractRecent summer surface air temperature (SAT) variations over Central East Asia (CEA) have been influenced by greenhouse gas and aerosol forcing since 1960. But how CEA SAT responds to contrasting changes in Asian, and European and North American aerosol sources remains unclear. By analyzing observations and model simulations, here we show that aerosol‐forced summer SAT changes over CEA since 1960 come mostly from the effects of aerosols outside Asia, with relatively small influences from Asian aerosols. Unlike Europe, where direct and indirect aerosol effects on surface solar radiation drive the SAT long‐term trend and decadal variations, over CEA atmospheric circulation response to aerosols outside Asia plays an important role. Aerosol‐forced anomalous low‐level low pressure in mid‐latitude Eurasia may influence the SAT anomalies downstream over mid‐latitude Asia, including a warm anomaly around CEA. The results suggest that caution is needed in attributing SAT changes around CEA to anthropogenic aerosols from Asia.
A bioinspired bubble removal method in microchannels based on angiosperm xylem embolism repair
Authors: Guo Lihua , Liu Yuanchang , Ran Penghui , Wang Gang , Shan Jie , Li Xudong , Liu Chong , Li Jingmin 
Published: March 2022

AbstractIt is difficult to remove and eliminate bubbles in microchannels in many devices used in various biomedical fields, such as those needed for microfluidic immunoassays, point-of-care testing, and cell biology evaluations. Accumulated bubbles are associated with a number of negative outcomes, including a decrease in device sensitivity, inaccuracy of analysis results, and even functional failure. Xylem conduits of angiosperm have the ability to remove bubbles in obstructed conduits. Inspired by such an embolism repair mechanism, this paper proposes a bioinspired bubble removal method, which exhibits a prominent ability to dissolve bubbles continuously within a large range of flow rates (2 µL/min–850 µL/min) while retaining the stability and continuity of the flow without auxiliary equipment. Such a method also shows significant bubble removal stability in dealing with Newtonian liquids and non-Newtonian fluids, especially with high viscosity (6.76 Pa s) and low velocity (152 nL/min). Such advantages associated with the proposed bioinspired method reveal promising application prospects in macro/microfluidic fields ranging from 3D printing, implantable devices, virus detection, and biomedical fluid processing to microscale reactor operation and beyond.
Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Authors: Fu Zhiwen , Li Shijun , Han Sifei , Shi Chen , Zhang Yu 
Published: March 2022

AbstractAntibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells, which has become one of the hotspots for the research and development of anticancer drugs. Since the first ADC, Mylotarg® (gemtuzumab ozogamicin), was approved in 2000 by the US Food and Drug Administration (FDA), there have been 14 ADCs received market approval so far worldwide. Moreover, over 100 ADC candidates have been investigated in clinical stages at present. This kind of new anti-cancer drugs, known as “biological missiles”, is leading a new era of targeted cancer therapy. Herein, we conducted a review of the history and general mechanism of action of ADCs, and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ADCs. Moreover, we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations, which provide insights for the research and development of novel cancer therapeutics using ADCs.