bluuebunny/crossref_metadata_2025_split huggingface dataset:
The conjunctival transcriptome in Ethiopians after trichiasis surgery: associations with the development of eyelid contour abnormalities and the effect of oral doxycycline treatment
Authors: Derrick Tamsyn , Habtamu Esmael , Tadesse Zerihun , Callahan E. Kelly , Worku Abebaw , Gashaw Bizuayehu , Macleod David , Mabey David C.W. , Holland Martin J. , Burton Matthew J. 
Published: November 2022

Background: Surgery to correct trichiasis is a key component of the World Health Organisation trachoma control strategy, however unfavourable outcomes such as eyelid contour abnormalities (ECA) following surgery are relatively common. This study aimed to understand the transcriptional changes associated with the early development of ECA and the impact of doxycycline, which has anti-inflammatory and anti-fibrotic properties, upon these transcription patterns. Methods: One thousand Ethiopians undergoing trichiasis surgery were enrolled in a randomised controlled trial following informed consent. Equal groups of randomly assigned individuals were orally administered with 100mg/day of doxycycline (n=499) or placebo (n=501) for 28 days. Conjunctival swabs were collected immediately prior to surgery and at one- and six-months post-surgery. 3’ mRNA sequencing was performed on paired baseline and one-month samples from 48 individuals; 12 in each treatment/outcome group (Placebo-Good outcome, Placebo-Poor outcome, Doxycycline-Good outcome, Doxycycline-Poor outcome). qPCR validation was then performed for 46 genes of interest in 145 individuals who developed ECA at one month and 145 matched controls, using samples from baseline, one and six months. Results: All treatment/outcome groups upregulated genes associated with wound healing pathways at one month relative to baseline, however no individual differences were detected between groups. The summed expression of a highly coexpressed cluster of pro-fibrotic genes was higher in patients that developed ECA in the placebo group relative to controls. qPCR validation revealed that all genes in this cluster and a number of other pro-inflammatory genes were strongly associated with ECA, however these associations were not modulated by trial arm. Conclusions: The development of post-operative ECA is associated with overexpression of pro-inflammatory and pro-fibrotic genes including growth factors, matrix metalloproteinases, collagens and extracellular matrix proteins. There was no evidence that doxycycline modulated the association between gene expression and ECA.
Effects of regular yoga practice on neurological conditions and mental health
Authors: Zadrozna Karolina , Wysokińska Olga , Żyga Justyna , Małek Anna , Fabiś Mateusz , Wójcik Bartłomiej , Iwaniszyn-Zapołoch Klara 
Published: November 2022

Introduction
Nowadays it is pointed out how important it is to take care of both mental and physical health. It is also undeniable that one affects the other and vice versa. That is why it is so important to nurture your body. Yoga as one of the physical activities has a proven effect on psychosomatic symptoms. Yoga is increasingly recommended mainly to relieve anxiety or stress. It brings great solace and even greater attentiveness. Lifestyle activities are increasingly considered an important component of treatment.

State of knowledge
Medical conditions such as dementia, Parkinson's disease, headaches, PTSD, depression are mainly treated with drugs. Yoga, as a non-pharmacological treatment, alleviates psychological conditions, as it reduces stress, anxiety, depressive symptoms, and enhances attentiveness to one's self, self-control and a different perspective on traumatic situations.

Conclusions
A review of the following works has shown the effects of yoga on mental health and common neurological conditions. With regular practice, it is possible to develop cognitive function, reduce the intensity and frequency of headaches. In Parkinson's disease, mindfulness exercises lead to an increase in muscle strength, a decrease in muscle tremors, and therefore improved rehabilitation. Most of the examples below mention a decrease in anxiety, stress, depressive symptoms and an increase in mindfulness, greater emotional and physical flexibility. The works cited point out that more in-depth research is needed to delve deeper into the effects of yoga on health.
Diagnosis and treatment of small intestinal bacterial overgrowth
Authors: Zadrozna Karolina , Wysokińska Olga , Małek Anna , Iwaniszyn-Zapołoch Klara , Wójcik Bartłomiej , Fabiś Mateusz , Żyga Justyna 
Published: November 2022

Introduction:
The human digestive tract contains 38 trillion bacteria in the colon. Physiologically, there is much less of them in other parts of digestive tract. The concentration of bacterial colonies grows along the intestine. Small intestinal bacterial overgrowth (SIBO) is characterized by an increased number of bacteria in the small intestine that correlates with gastrointestinal symptoms. The main symptoms of SIBO are bdominal bloating and diarrhea. Diagnostic methods used in SIBO include measuring methane or hydrogen levels. However, the use of antibiotics is prevalent, there is still a necessity to search for the gold standard of treatment.

Objective:
The purpose of this paper is to review the current knowledge on the management of patients with proliferative small intestinal bacterial flora syndrome. Particular attention was paid to the types of diagnosis and treatment of this ailment in recent years.

Material and methods:
The review includes publications published in 2001- 2022. Data were collected using PubMed or az published online American College of Gastroenterology (ACG) 2020 guidelines.

Results:
SIBO is an incompletely understood disease. Its symptoms are nonspecific and found in many gastrointestinal disorders, and its diagnosis is not fully specified. The gold standard for diagnosis is the collection of a small bowel aspirate during endoscopic examination. Antibacterial treatment is given empirically, mainly rifaximin, while other types of treatment are not strongly established in the publications.

Conclusions:
The lack of standardized management and the lack of sufficient evidence for the effectiveness of current methods make SIBO a recurrent complaint. All above aspects confirm that SIBO requires a lot of research to provide better life quality for these patients.
Impact of hidradenitis suppurativa-specific wound dressing system on patient quality of life and dressing-related pain: pilot study
Authors: Moloney Suzanne , Fitzgerald David , Roshan Davood , Gethin Georgina 
Published: November 2022

Objective: It is theorised that adhesive-free wound care developed specifically for patients with hidradenitis suppurativa (HS) can improve their quality of life (QoL). Our study aimed to investigate the impact of a novel wound care device on Dermatology Life Quality Index (DLQI) scores, and other factors related to experienced pain, time spent changing dressings, comfort, ease of use and body image. Method: A 21-day, single-arm, unblinded, pilot trial was conducted to assess ease of use and the impact of effective wound care on various aspects of wound management in patients with HS. Participants were provided two trial garments and trial dressings as required, to use over a 21-day period in the home setting. A seven-item questionnaire and the DLQI questionnaire was completed on days 0, 7, 14 and 21. Results: All 15 participants were female, aged >18 years old and with a diagnosis of HS. Mean DLQI score at baseline (day 0) was 19.3, which was reduced to 4.53 on day 21, a significant improvement in 100% of participants (p<0.001). High levels of dressing-related pain, assessed using an 11-point Visual Analogue Scale, reduced from 5.53 at baseline to 0.8 on day 21. Other significant improvements in terms of patient comfort, time spent on changing dressings, body confidence and the dressing's ability to retain exudate were also noted. Conclusion: The results illustrated the improvement made to study participants' day-to-day activities and QoL when effective HS-specific wound care products were provided. Wound care is an essential component in the treatment journey of patients.
Comparative studies of structural and optical properties of Nb2O5–Sb2O3–TeO2 glass and glass-ceramics
Authors:   JNTUHCEJ, Siripuram Rajesh , Satya Gopal Rao P. , Sripada Suresh ,   GRIET
Published: November 2022

A new, transparent antimony-tellurite glass and glass-ceramic systems doped with Nb2O5 have been prepared by using the conventional melt quenching method and heat treatment process, respectively. Various physical, optical and structural studies were reported through XRD, TEM, SEM, ultraviolet-visible, Raman, infrared and ESR investigations. XRD analysis of glass and glass-ceramic samples revealed their amorphous and crystalline natures, respectively. The Williamson-Hall approach was used to determine the average crystallite size of synthesised glass-ceramics and the values were found to be in the range of 23 to 85 nm. The SEM result reveals that glass-ceramics contain perspicuous and haphazardly distributed nanoclusters possessing sizes in the range of 45 to 120 nm. TEM analysis shows the size of particles in the glass-ceramics is in the range of 10 to 90 nm. The Eopt of the glass system has decreased from 2·873 to 2·606 eV, whereas in the glass-ceramic system it is observed to increase from 1·340 to 1·748 eV. Raman and infrared spectral analysis confirm the existence of various structural units such as TeO4, TeO3+1, TeO3, NbO6, NbO4, SbO3 in the glass and glass ceramic systems.The ESR spectral analysis reveals that the (Δg‖/Δg^) parameter seems to decrease from 4·444 to 2·453 in glass sytem, whereas in glass-ceramics it is observed to increase from 2·357 to 4·188. Glass transition temperature and onset crystalline temperatures are influenced by the Nb2O5 in both glass and glass-ceramic samples.
Perceptions and priorities for the development of multiplex rapid diagnostic tests for acute non-malarial fever in rural South and Southeast Asia: An international modified e-Delphi survey
Authors: Chew Rusheng , Lohavittayavikant Salisa , Mayer Matthew , Day Nicholas Philip John , Lubell Yoel 
Published: November 2022

BackgroundFever is a common presenting symptom in low- and middle-income countries (LMICs). It was previously assumed that malaria was the cause in such patients, but its incidence has declined rapidly. The urgent need to develop point-of-care tests for the most important causes of non-malarial acute febrile illness is hampered by the lack of robust epidemiological data. We sought to obtain expert consensus on analytes which should be prioritized for inclusion in fingerprick blood-based multiplex lateral flow rapid diagnostic tests (LF-RDTs) targeted towards four categories of patients with acute non-malarial fever in South and Southeast Asian LMICs, stratified by age (paediatric vs. adult) and care setting (primary vs. secondary care).Methodology/Principal findingsWe conducted a two-round modified e-Delphi survey. A total of 84 panellists were invited, consisting of seven each from 12 countries, divided into three regional panels (Mainland Southeast Asia, Maritime Southeast Asia, and South Asia). Panellists were asked to rank their top seven analytes for inclusion in LF-RDTs to be used in each patient category, justify their choices, and indicate whether such LF-RDTs should be incorporated into algorithm-based clinical decision support tools. Thirty-six panellists (43%) participated in the first round and 44 (52%) in the second. There was consensus that such LF-RDTs should be incorporated into clinical decision support tools. At a minimum, these LF-RDTs should be able to diagnose dengue and enteric fever in all patient categories. There was a clear preference to develop LF-RDTs for pathogens not readily detected by existing technologies, and for direct diagnosis through antigen detection. Pathogen biomarkers were prioritized over host inflammatory biomarkers, with CRP being the only one ranked consistently highly.Conclusions/SignificanceOur results provide guidance on prioritizing analytes for inclusion in context-specific multiplex LF-RDTs and similar platforms for non-malarial acute febrile illness, for which there is an urgent unmet need.
Vitamin D deficiency in low-birth-weight infants in Uganda; a cross sectional study
Authors: Chebet Martin , Piloya Thereza , Ameda Faith , Mukunya David , Kiguli Sarah 
Published: November 2022

Background
Vitamin D deficiency affects 7–86% of infants globally and results in recurrent infections, impaired growth and nutritional rickets. Low-birth-weight infants in Uganda are at risk of vitamin D deficiency due to limited sunlight exposure and dependence on breastmilk. We aimed to determine the prevalence and factors associated with vitamin D deficiency among low-birth-weight infants aged 6 weeks to 6 months at Mulago national referral hospital in Uganda.

Methods
We conducted a cross-sectional study at Mulago Hospital between September 2016 and March 2017. We enrolled infants born with low birth weight between six weeks and six months whose mothers were available and willing to provide informed consent. Upon obtaining informed consent, we administered a structured questionnaire and performed a physical examination on the participants. Blood was drawn for calcium, phosphorus and vitamin D estimation. We measured serum 25 hydroxy vitamin D (25(OH)D) using the electrochemiluminescence method. Vitamin D deficiency and insufficiency were defined as (25(OH)D) < 20ng/ml and from 20ng/ml to <30 ng/ml respectively. To determine factors associated with vitamin D deficiency, we fit multivariable logistic regression models with exposure factors determined a priori. Data were analysed using Stata version 14.

Results
We enrolled 297 participants, 49.2% (167/297) of whom were males. The median infant age was nine weeks (interquartile range 7–13). All infants had less than one hour of sunlight exposure and over 90.6% (269/297) had received multivitamin supplements containing vitamin D. The prevalence of vitamin D deficiency was 12.1% (36/297): 95% CI (8.9%-16.4%). The prevalence of vitamin D insufficiency was 19.9% (59/297): 95% CI (15.7%-24.8%). Boys had higher odds of vitamin D deficiency compared to girls [adjusted odds ratio 2.8: 95% CI 1.3–6.1].

Conclusion
Vitamin D deficiency was 12.1% among low-birth-weight infants in Uganda although almost all of them had received multivitamin supplements containing vitamin D. We recommend that more studies are done in low-birth-weight infants to assess the risk factors for vitamin D in these population in Uganda.
Social, psychological and health characteristics associated with stability and change in adult alcohol consumption
Authors: Michelsen Martin Ekholm , Grønkjær Marie , Mortensen Erik Lykke , Wimmelmann Cathrine Lawaetz 
Published: November 2022

Background
Many studies analyzing health effects of alcohol consumption have operationalized alcohol intake from a single baseline measure without further follow-up. Consequently, there is a lack of knowledge about stability and change in alcohol consumption over the life course and the social, psychological, lifestyle, and health characteristics associated with different alcohol consumption trajectories.

Objectives
The aims of the study were to describe the prevalence of different adult-life alcohol consumption trajectories among Danish men and to analyze social, psychological, lifestyle and health characteristics associated with these trajectories.

Methods
For 2510 Danish men, retrospective decade-based information on alcohol consumption during life period 26–60 years was obtained in late midlife and information on individual characteristics was obtained in young adulthood, late midlife and from national hospital registries. The men were allocated to one of six a priori defined alcohol consumption trajectories.

Results
About 65% of Danish men had a stable moderate consumption, drinking 1–21 units weekly while the five other consumption trajectories were comparatively rare: 3% stable abstainers, 4.7% stable high-risk drinkers, 10.9% with increasing and 12.7% with decreasing consumption. Moderate consumption over the adult life-course was associated with the most favorable social, psychological, lifestyle and health characteristics while the other trajectories were generally associated with less favorable characteristics to varying degrees–e. g. this was the case for the stable abstaining trajectory and in particular the trajectory with decreasing consumption.

Conclusion
The findings suggest that the majority of Danish men drink moderately in the life period from young adulthood to late midlife, and deviance from this ‘normal’ moderate consumption trajectory is associated with less favorable social, psychological, lifestyle and health characteristics. Some of these characteristics may influence alcohol consumption patterns, but for some of the trajectories, alcohol consumption may influence health as well as social and psychological functioning.
Judenfeindschaft und Gefühl: Emotionsreflexion als notwendige methodische Ergänzung antisemitismuskritischer Bildung
Authors: Meier Moritz Y. 
Published: November 2022

Abstract
Antisemitism today is omnipresent, yet mostly misunderstood, underestimated and trivialized. In schools as well, antisemitic acts are becoming increasingly aggressive and expressible. To combat and prevent Jew-hatred has been the ongoing commitment of antisemitism-critical education. Nevertheless, a (critical) theory-driven insight into the functionality of antisemitism raises why the current educational practice that can be stated as merely imparting knowledge and facts is not sufficient but, urgently, must be supplemented by a self-related and emotion-reflective approach developed in this paper in order to be able to achieve more sustainable success on the educational level. The need to deeper reflect on emotions and the subconsciousness as major roots of antisemitism leads the author to the proposal of specific dialogical-introspective methods, which will be critically contextualized in the end.
Der Mythos vom »Import«. Islamische Codes und europäische Ideologie im muslimischen Antisemitismus
Authors: Henning Philipp 
Published: November 2022

Abstract
Today’s anti-Semitism in European societies is often said to have been imported on a large scale by Muslim immigrants. It needs to be revealed that this is a historically abbreviated representation useful for particular political purposes – especially from the right. The influence of medieval European-Christian anti-Judaism and modern anti-Semitism on the Muslim world has a centuries-old history and is usually disregarded in the debate. Nevertheless, there are clear anti-Jewish terms and conventions in Islamic tradition. However, some of these codes are not immediately recognizable as anti-Jewish to a European audience. They are still widely used in today’s politics and popular culture of Muslim societies both in the Middle East and the West. The article aims to provide orientation on the genesis and development of this cultural exchange of hate and refute one-sided accusations.
Kodierungen des Antisemitismus. Überlegungen zum Einfluss von Sprache, Recht und Justiz auf die Gestalt der Judenfeindschaft in Deutschland im 19. und 20. Jahrhundert
Authors: Jahr Christoph 
Published: November 2022

Abstract
Using examples from the late 19th century to the present, it will be discussed to what extent anti-Semitism was shaped by a »legal code«. The pressure of legal repression, however weak it may have been at times, caused anti-Semites to retreat to language formulas that were no longer (or not yet) legally objectionable, without therefore giving up their convictions. This borderline is fundamentally semantically indeterminable, because associations, puns and cynicism cannot be banned. The legal instruments often come to nothing, because a judiciary under the rule of law may only sanction deeds, not thoughts. Each judgement inevitably redefines this borderline, at least in nuances. By contributing in this way to constituting the discursive framework of anti-Semitism, even if there is a broad social consensus of its ostracism, the law is both a partial solution and part of the problem.
Prognostic value of procalcitonin in cancer patients with coronavirus disease 2019
Authors: Tiutan Timothy , Wallins Joseph S. , Brown Samantha , Gonen Mithat , Korenstein Deborah 
Published: November 2022

Abstract

Objectives
Many biomarkers have been studied to assist in the risk stratification and prognostication of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Procalcitonin (PCT), a circulating precursor of the hormone calcitonin, has been studied with mixed results as a predictor of severe coronavirus disease 2019 (COVID-19) in the general population; however, to date, no studies have focused on the utility of PCT in predicting disease severity and death from COVID-19 in the cancer population.

Methods
We conducted a retrospective study of cancer patients hospitalized with COVID-19 at a comprehensive cancer center over a 10-month period who had PCT recorded on admission. We assessed associations between variables of clinical interest and the primary outcomes of progression of COVID-19 and death during or within 30 days of hospitalization using univariable and multivariable logistic regression.

Results
The study included 209 unique patients. In the univariate analysis, elevated PCT on admission was associated with higher odds of progression of COVID-19 or death (Odds ratio [OR] 1.40, 95% CI 1.08–1.93) and mortality alone (OR 1.53, 95% CI 1.17–2.11). In multivariate regression, PCT remained significantly associated with progression or death after holding chronic kidney disease (CKD) status constant (OR 1.40, 95% CI: 1.08, 1.93, p=0.003). Similarly, the association of PCT and death remained significant after adjusting for age (OR 1.54, 95% CI: 1.17–2.15).

Conclusions
In hospitalized COVID-19 patients with underlying cancer, initial PCT levels on admission may be associated with prognosis, involving higher odds of progression of COVID-19 and/or mortality.
A flexible framework for requirement management (FFRM) from software architecture toward distributed agile framework
Authors: Nadeem Rao , Amir Latif Rana M. , Hussain Khalid , Jhanjhi N. Z. , Humayun Mamoona 
Published: November 2022

Abstract
GSD is a Global software development environment where data are distributed to more than two sites. These sites may be located on national or continental borders. Every year it expands its development volume, which has become a trend for the software development business. Because of increasing demand, it has become a common type of business. The value of offshore software development has increased immensely. According to the recent predictions, one-quarter of US software-related business shifts offshore, including integration and management-related services. GSD helps explore resources from other countries, increasing knowledge and enhancing operational efficiency. Therefore, globalization has changed the development nature of software. Different organizations face several challenges, such as coordination and requirement ambiguity, during the change management process in GSD. Traceability accommodates these changes in forward and backward direction. However, it gives rise to several challenges like less client involvement because of its distributed nature and challenging to manage the requirement ambiguity due to increased cost. Therefore, the Flexible Framework for Requirement Management (FFRM) must handle the abovementioned issues.