bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of oncological outcomes between radical hysterectomy and radiochemotherapy for FIGO 2018 stage IIIC1 cervical adenocarcinoma：a retrospective multicentre cohort study
Authors: Yin Zhaohong , Sun Lixin , Gao Zhenwei , Zhao Hongwei , Chen Chunlin , Liu Ping 
Published: December 2022

Abstract
Background To compare oncological outcomes of radical hysterectomy (RH) and radiochemotherapy (R-CT) for stage IIIC1 (FIGO 2018) cervical adenocarcinoma patients. Methods Based on the Chinese cervical cancer clinical diagnosis and treatment project database,236 cases with 2018 FIGO stage IIIC1 cervical adenocarcinoma from 2005 to 2019 were reviewed. The 5-year OS and 5-year DFS of patients with either of the two treatment methods were compared by means of a multivariate Cox regression model and the log-rank method in the total study population and after propensity score matching (PSM). Results We selected 236 of 63,926 patients with 203 patients in the RH group and 33 patients in the R-CT group and then found that R-CT was associated with a significantly worse 5-year OS (51.8% vs. 67.2%, P < 0.05) and 5-year DFS (43.1% vs.60.1%, P < 0.05) than RH in the total study population. R-CT is an independent risk factor for 5-year DFS(HR = 2.226, 95% CI 1.141–4.343, P < 0.05) in FIGO stage IIIC1 cervical adenocarcinoma, but not for 5-year OS(hazard ratio (HR) = 1.834 ,95% CI 0.829–4.061, P ༜ 0.05).After matching (n = 26/73), among FIGO 2018 IIIC1 adenocarcinoma patients the 5-year OS and DFS were lower in the R-CT group than in the RH group,the difference was statistically significant (OS: 50.3%vs77.4%,P ༜ 0.05;DFS: 38.2% vs. 65.0%, P < 0.05, respectively).R-CT is an independent risk factor for 5-year DFS(HR = 2.299, 95% CI 1.113–4.750, P < 0.05) in FIGO stage IIIC1 cervical adenocarcinoma, but not for 5-year OS(HR: 1.926, 95% CI:0.792–4.682, P ༞ 0.05). Conclusion Among patients with stage FIGO 2018 IIIC1 cervical cancer adenocarcinoma, R-CT was not associated with better oncological outcomes than RH.Radiotherapy should not be the only recommended treatment.
A Comparison of adjustable positioning and free positioning after pars plana vitrectomy for rhegmatogenous retinal detachment
Authors: Liang Qianqian , Sun Difang , Xue Shuyue , Li Xinying , Liu Xin , Du Qing , Zhang Zhichun , Li Jun 
Published: December 2022

Abstract
Purpose: To compare the effectiveness and safety of adjustable and free postoperative positioning after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).
Methods: In this prospective, randomized controlled study, a total of 94 eyes with RRD were enrolled from April 2020 to September 2021, and monitored postoperatively for at least 3 months. All patients underwent PPV combined with silicone oil injection or gas tamponade and were randomly divided postoperatively into two groups: an adjustable positioning group and a free positioning group. The success of the outcome was based on the retinal reattachment rate, best corrected visual acuity (BCVA), postoperative complications, and ocular biometric parameters such as anterior chamber depth (ACD) and lens thickness (LT).
Results: The initial retinal reattachment rate was 97.9% in the adjustable positioning group and 95.7% in the free positioning group, manifesting no statistical difference between the two groups. Similarly, no statistical difference was observed between the two groups in the final BCVA, which was significantly improved compared to the preoperative BCVA. The comparison of the 1-month postoperative ACD and LT with the preoperative values showed no statistically significant differences in the two groups. The rates of complications were not statistically different in the two groups. Conclusion: After treating RRD using PPV, neither the adjustable nor the free postoperative positioning affected the retinal reattachment rate or the incidence of complications. Therefore, our study showed that it is safe and effective to adopt free positioning postoperatively, which may provide more options for patients with RRD undergoing PPV.
Prevalence and characteristics of the anterior loop in adult patients using Cone Beam computed tomography: A Cross-sectional study
Authors: Alva-Torres Laura , Chacón-Uscamaita Pamela Roxana , Chávez-Rimache Lesly , Grados-Pomarino Sixto , Gamarra-Contreras María del Pilar , Chumpitaz-Cerrate Victor 
Published: December 2022

Abstract
Background: The anterior loop is the extension of the inferior dental nerve which is one of the most important anatomical landmarks to consider when placing dental implants or any other surgical procedure that involves the chin region. Determining the frequency and characteristics of the anterior loop is important to reduce the risk of complications in the chin region as a result of the implant or regenerative surgeries. For this reason, the objective of the study was to determine the prevalence and characteristics of the anterior loop in adult patients using Cone Beam computed tomography.
Methods: A Cross-sectional study of 93 Cone Beam computed topographies (CBCT) obtained from patients of the Faculty of Dentistry of the UNMSM during the period 2016-2017. CBCTs were analyzed and measurements of the anterior projection (AP) and caudal projection (CP) of the anterior loop were performed. In addition, the distance of the anterior loop to the alveolar ridge (D-AR) and the buccal table (D-BP) was evaluated.
Results: The prevalence of the anterior loop was 95.1% (n=177) and with an average AP of 2.67 ± 1.36 mm. In AP and CP, a significant difference was evidenced concerning dental status on the right side (p <0.05). The CP of the anterior loop was 5.27 ± 1.69 mm; the rods presented a higher value on the side with 5.94 ± 2.01 mm (p = 0.01); the completely edentulous patients presented a higher value on the side with 7.00 ± 1.13 mm (p = 0.036). The D-AR was 15.33 ± 2.45 mm and the D-BP was 4.97 ± 1.40 mm.
Conclusions: In this study, it was found that there is a high prevalence of the anterior loop (95.1%) with an average length of 2.67 mm. In addition, some characteristics associated with the anterior loop were found, such as its anterior projection with dental status and its caudal projection with gender and dental status.
Effects of Character Positional Frequency in Chinese Silent and Oral Reading: Evidence from Eye Movements
Authors: Cao Haibo , Zhang Kuo , Wang Jingxin 
Published: December 2022

Abstract

The cognitive mechanisms underlying Chinese word segmentation remain obscure. However, studies have found that readers can use character position probability to facilitate word segmentation even though the Chinese script does not use spaces. Surprisingly little is known about how this ability is employed during silent and oral reading. The present study manipulated both initial and final character positional frequencies of target words of either high or low lexical frequency. The results revealed a significant reading model effect, as longer fixations occur in oral than in silent reading, and importantly showed a privileged status for initial character positional frequency during word segmentation. An effect of initial character positional frequency was found during silent and oral reading, which indicates that readers effectively use character positional frequency to boost word recognition. Moreover, the initial character’s positional frequency contributed significantly to the processing of the target word under low-frequency conditions. Taken together, the information on character location probability is an important clue for readers to segment words, and this processing advantage of the character positional frequency is driven by the word frequency. The findings are an enhancement to the development of the character positional decoding model across Chinese reading.
Targeting a secreted fungal effector protein providing a novel concept in combating rice blast
Authors: Liu Muxing , Wang Fangfang , He Bo , Hu Jiexiong , Dai Ying , Chen Weizhong , Zhang Haifeng , Ye Yonghao , Cui Zhongli , Zheng Xiaobo , Wang Ping , Xing Weiman , Zhang Zhengguang 
Published: December 2022

Abstract
Effector proteins secreted by plant pathogenic fungi are important artilleries against host immunity, but there is no precedent that such effectors were explored as antifungal targets. We here provide evidence that MoErs1, a species-specific effector protein secreted by the rice blast fungus Magnaporthe oryzae, effectively controls the rice blast. MoErs1 inhibits the function of OsRD21, a rice papain-like cysteine protease (PLCP) that positively regulates rice immunity. Based on the protein structure of MoErs1, we designed FY21001, a diphenyl ether ester compound that binds specifically to MoErs1 to inhibit its function. Importantly, we showed that FY21001 effectively controls the rice blast in field tests. Our study reveals a novel concept targeting pathogen species-specific effector proteins in crop disease control and management.
Effect of low-intensity focused ultrasound of right anteromedial cortico-subcortical circuits on repetitive negative and self-referential thinking in depression: a sham-controlled randomized feasibility trial
Authors: Guinjoan Salvador , Tsuchiyagaito Aki , Khalsa Sahib , Kuplicki Rayus , Sanchez Stella , Park Heekyeong , Misaki Masaya , Rohan Michael , Paulus Martin 
Published: December 2022

Abstract
Background

Depression (MDD) is associated with an unusually large amount of individual disability and societal costs as well as unsatisfactory outcomes with well-established therapies, including psychotropic drugs and different types of psychotherapy. Based on increasing interest in modulation of brain circuits involved in specific symptoms of depression, we chose to target a single measurable and replicable construct of depression, repetitive negative thinking (RNT), a transdiagnostic clinical manifestation that cuts across a variety of internalizing psychiatric disorders, but in the case of depression, it is associated with persistent symptoms, treatment resistance, proneness to relapse after treatment, and more suicidal ideation, behavior, and completed suicides. With the help of using low-intensity transcranial focused ultrasound (LIFU), we will modulate individually-identified neural circuits associated with (a) the generation and maintenance of repetitive negative thinking (RNT), and (b) affective processing of self-referential adjectives.

Methods

The study will consist of two groups/arms subjected consecutively to either LIFU sonication or sham sonication in a crossover fashion. It will be a single-site, pilot study involving 20 participants with depression (10 with low RNT and 10 with high RNT) and 10 healthy controls. This project has two phases. First, we will use advanced structural-functional connectivity analysis techniques to individually define anatomical tracts that support functional connectivity alterations associated with the intensity of RNT in each MDD patient. Informed by recent neurocircuitry evidence in MDD and obsessive-compulsive disorder we hypothesize that structural pathways linking the thalamus, the orbitofrontal cortex, and the anterior cingulate cortex in the right hemisphere will be associated with RNT. Second, by using the resulting pathways to guide the choice of the target(s) for LIFU neuromodulation, we will probe its on (1) measures of RNT (Brief State Rumination Inventory), (2) functional connectivity between regions known to have an anatomical connection in the individual participant, and (3) neural processing of self-referential affective adjectives.

Discussion

We anticipate this feasibility study will provide the information necessary for the design of a larger-scale clinical trial to establish 1) a definitive causal relationship between brain circuits and RNT as a symptom, and 2) a novel target to modulate RNT in the clinical setting.
Trial registration: In process at ClinicalTrials.gov. FDA Non-Significant Risk determination Q220192 (November 4, 2022).
LC-MS detected universal metabolites of human day 3 embryos with distinct implantation outcomes for Cook Medical and Vitrolife culture medium
Authors: Shi Cheng , Liu Ying , Fu Min , Liang Rong , Wang Ping , ShengNan Duan , Chen YuNan , Zhou Yinglin , Shen Huan , Chen Xi 
Published: December 2022

Abstract
Background
To implore the universal metabolites from metabolomic profiling of spent embryo culture medium (SECM) correlated to day 3 embryo’s implantation potential in two commercial culture medium (Cook Medical and Vitrolife).
Methods
This investigation was a prospective randomized study. Patients undergoing IVF-ET and having utilizable day 3 embryos were recruited. Patients were randomized for embryo culture in Cook Medical or Vitrolife medium. On day 1 each zygote of patients was individually cultured in a 30 µL microdroplet until day 3. Then SECM from each microdroplet was collected within 2 hours after the embryo was utilized (transferred or frozen) and detected by Liquid Chromatography-Mass Spectrometry (LC-MS).
Results
For Vitrolife medium, 3 batches of total 69 SECM samples were collected. According to the embryo’s implantation outcome, 17 were successfully implanted group, while 52 were failed implanted group. 147 metabolomic irons presenting significantly different level between the two groups were identified as the Vitrolife metabolomic profiling set. For Cook Medical medium, 2 batches of total 37 SECM samples were collected. According to the embryo’s implantation outcome, 14 were successfully implanted group, while 23 were failed implanted group. 435 metabolomic irons presenting significantly different level between the two groups as the Cook Medical metabolomic profiling set. There were 66 universal metabolites between the Vitrolife and Cook Medical metabolomic profiling set and the ion with m/z = 121.029 was the most reproduciable signature, which was identified to be benzoic acid.
Conclusions
Metabolomic profiling in SECM correlated to day 3 embryo’s implantation potential in Vitrolife and Cook Medical medium could be sensitively detected by LC-MS approach. The universal metabolites for the two commercial medium, such as benzoic acid, may provide a potential solid adjunct to day 3 embryo’s evaluation.
Evaluating the Quality of Life for Sustainable Urban Development
Authors: Takano Tsuyoshi , Morita Hiroyoshi , Nakamura Shinichiro , Hayashi Yoshitsugu , Togawa Takuya , Kachi Noriyasu , Kato Hirokazu 
Published: December 2022

Abstract
As urbanization is rapidly progressing worldwide, the cities need to assess their quality of life (QOL) not only to check their infrastructure, but also to keep pace with the changing values and lifestyles of citizens. We propose an integrated method to evaluate QOL from the detailed spatial aspects of a city with the subjective values of its citizens. In this study, the spatial data on a 500-m mesh scale and the subjective values on individual attributes of the urban environment are obtained to evaluate the QOL in five metropolitan areas in Japan. The QOL within a city was found to vary both by region and by individual attributes. The results provide a scientific basis for urban policies that achieve diversity and inclusiveness.
Road safety stakeholders’ perspectives of risk factors, opportunities and barriers for child pedestrians in Uganda: A qualitative study
Authors: Osuret Jimmy , Kobusingye Olive , Nankabirwa Victoria , Niekerk Ashley Van , Atuyambe Lynn 
Published: December 2022

Abstract
Background
The health and socio-economic burden of road traffic injuries on children and their caretaker is extremely high in Uganda where 33% (1,384/4,159) of road traffic fatalities were among child pedestrians in 2021. We explored the road safety situation in Kampala, Uganda to understand the child pedestrian risk factors associated to road traffic injuries (RTIs), opportunities and underlying barriers to child pedestrian safety.
Methods
We conducted a qualitative study in 2021 using two primary methods of Key informant interviews and focus group discussions. Overall, we conducted 12 key informant interviews with stakeholders involved in road safety and 6 focus group discussions which comprised 18 teachers and 17 parents. Data was analyzed using thematic analysis technique. ATLAS ti. 9 was applied for data management and during analysis, three themes were developed.
Results
Child pedestrian RTIs were related to the behaviour of the driver (e.g. speeding, driver distraction) and pedestrian (e.g. risk taking); traffic (e.g. complex traffic mix); the road infrastructure (e.g. inadequate pedestrian facilities); and the vehicle (e.g. technical defects). Pedestrian safety opportunities identified included roadside police enforcement and assistance of children to cross by a school traffic warden. The key barriers to pedestrian safety included limited political commitment, inadequate funding, and inadequate enforcement.
Conclusion
This paper has presented evidence that pedestrian road traffic crashes occur due to an interplay of multiple risk factors and yet low priority is placed on road safety. The findings highlight the key risks faced by children in low-income settings like Uganda and recommend prioritizing holistic measures that include enforcement, school traffic control measures and pedestrian road safety infrastructure.
Nutrition Therapies for Diverticulitis Related to Alcohol Abuse: A Case Report
Authors: Hollywood Jasmine B. 
Published: December 2022

Abstract
Background
As alcohol use becomes more prevalent, it has become a risk factor for not only mental health but also other illnesses such as diverticulitis. Successful therapeutic interventions that support the elimination of addictive behaviors and reduce disease progression include diet, supplement, and psychosocial interventions.
Case Presentation
This case report highlights a client with successful treatment of bowel blockage and inflammation in an individual patient, a 54-yr-old Caucasian male using nutritional support. This individual continued conventional interventions while starting medical nutrition therapy. Over the course of 85 days, his treatment was augmented with a high-phytonutrient, high-fiber, Mediterranean style diet. Alcohol was eliminated, caloric intake was increased, and emotional support, physical activity, and a multivitamin was added. Upon final follow-up, the client had a significant reduction in symptoms and addictive behaviors along with resolution of colon blockage and inflammation.
Conclusion
Diet, supplement, and psychosocial interventions may be useful in the management of inebriated patients with diverticulitis. Population-based clinical studies should be done to understand the role of these therapies.
Performance of the CORDEX-Africa Regional Climate Model in capturing precipitation and air temperature conditions in the Omo Gibe River Basin, Ethiopia
Authors: Mathewos Yonas , Abate Brook , Dadi Mulugeta 
Published: December 2022

Abstract
Using regional climate models (RCMs) and ensembles of multiple model simulation outputs without assessing their modeling performance did not always ensure the best agreement between observed and modeled climate variables. To this end, assessing the modeling performance of regional climate models (RCMs) is indispensable in selecting the most effective model to use for climate change impact studies. In this study, the performance of ten Coordinated Regional Climate Downscaling Experiments (CORDEX) in Africa was examined against observational datasets from 1986 to 2005 across the entire Omo Gibe River Basin (OGRB). The output of RCMs was evaluated based on their ability to reproduce the magnitude and pattern of monthly, seasonal, and annual precipitation and air temperature, precipitation characteristics, and statistical metrics. The results confirm the difference between RCMs in capturing climate conditions at both spatial and temporal scales. The spatial pattern of mean annual precipitation was better reproduced by the ensemble mean and RACMO22T (EC-EARTH). CCLM4-8-17 (MPI) and the ensemble mean reproduced the annual patterns of observed precipitation, even though the amounts were different. Except for peak precipitation, all RCMs simulated seasonal precipitation, and the pattern was reasonably captured by RACMO22T (EC-EARTH), CCLM4-8-17 (CNRM), RCA4 (CNRM), CCLM4-8-17 (MPI), and REMO2009 (MPI). The interannual and seasonal variability of precipitation was higher than the variability of air temperature. It was found that observed and RCM precipitation simulations using CCLM4-8-17 (MPI), REMO2009 (MPI), and RCA4 (CNRM) showed better agreement at several individual stations in the Omo Gibe River Basin (OGRB. Likewise, RCA4 (MPI) and CCLM4-8-17 (MPI) were superior in capturing minimum and maximum air temperatures. The cumulative distribution of extreme precipitation was better captured by RCA4 (MIROC5), and all RCMs, including their ensemble mean, overestimated the return period. Overall, the study emphasizes that the selection of robust RCMs that better reproduce observed climate conditions and the use of multi-model ensembles of models with the best performance after systematic bias correction are fundamentally necessary for any study of climate change impacts and adaptation in the OGRB.
Analysis of bacterial and fungal community structure in Panax notoginseng rhizosphere samples from different locations
Authors: Lou Yang , Zhang Zilong 
Published: December 2022

Abstract
Panax notoginseng is a well-known Chinese herb that is used worldwide. The goal of this work was to explore the diversity and structure of rhizosphere microbial communities of Panax notoginseng. To do this, Panax notoginseng rhizosphere soil samples were collected from ten production areas in China, and the 16SrRNA and internal transcribed spacer (ITS1) sequences were analyzed by Illumina high-throughput sequencing technology. The results revealed similar species composition of fungal and bacterial communities in the different producing areas, but significant variation in the abundances of some dominant flora. Redundancy analysis showed that environmental factors explained 41.3% of the fungal community and 45.7% of the bacterial community. We detected significant enrichment of some root rot pathogens, including Ilyonectria, Fusarium, and Pseudomonas, in samples from Wenshan City and Yunnan Province. In summary, the results reveal differences in the structure of rhizosphere soil microbial community of Panax notoginseng in different production areas. The beneficial fungus Chaetomium was the most abundant, with an average abundance of 19.65%. The results can guide strategies to improve Panax notoginseng quality and yield and for biological control of root rot in Panax notoginseng.