bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of SO 2 absorption in a spray tower using CFD
Authors: Novickis Charles , Ferreira Daniel José Oliveira , Park Song Won , Codolo Milene Costa 
Published: December 2022

Abstract
Gas scrubbers are important equipment for air pollution removal. Among the scrubbers we can highlight the spray tower, which has several advantages, such as low pressure drop, easy maintenance and low operational costs. However, the velocity profile inside this equipment is complex, making its analysis and design very difficult. Therefore, the present work aims to perform numerical simulations using CFD (Computational Fluid Dynamics) using Euler-Lagrange approach applied to a spray tower for SO2 absorption. The simulations evaluated the influence of the following variables on velocity and SO2 profiles, as gas and liquid flow rates, size droplet distribution and spray nozzles with different orifice diameters. The results obtained by CFD simulations showed the main absorption zones in the column and the influence of gas velocity, particle trajectories and droplet diameter in the sulfur dioxide absorption process. Furthermore, the experimental efficiencies were compared with the simulated for two conditions, the first condition with an experimental efficiency of 89% presented a simulated efficiency of 79.6% and the second condition with an experimental efficiency of 98.27% presented a simulated efficiency of 100%. This shows a good approximation between the simulated and experimental results
A kinetic impact strategy for deflecting an asteroid to form a gravity tractor system with a potentially hazardous asteroid
Authors: Gao Youtao , Fu Yuhai , Dong Zezheng , Cheng Yi , You Zhicheng , Dong Guocang , Bian Yue 
Published: December 2022

Abstract
Near-Earth asteroids pose an enormous threat to Earth. Removing them effectively from risk orbits is a crucial issue. To improve the deflection efficiency, we propose a method to control an intermediate asteroid as a gravity tractor to change the orbit of potentially hazardous asteroid. A multiple kinetic impact method is applied to an intermediate asteroid to change its orbit toward the potentially hazardous asteroid. The goal of multiple kinetic impacts is to control the intermediate asteroid to form a gravity tractor system with the potentially hazardous asteroid. First, we chose an asteroid that requires smaller transfer velocity increments as an intermediate asteroid. Then, we design the orbit of the gravity tractor system and use a multi-objective harris hawk optimization algorithm to optimize the kinetic impact mission. Finally, the effects of direct transfer model, multi-pulse transfer model, and gravity assist transfer model are investigated respectively. We compare the three transfer models and obtain a suitable kinetic impact deflection scheme. The results show that the proposed method can effectively deflect the potentially hazardous asteroid. Using an asteroid as a gravity tractor can greatly increase the deflection distance. Deflection distances can be increased from hundreds of kilometers to fractions of an AU.
Bis (2-Cyanoacetohydrazide) as Precursors for Synthesis of Novel Azoles / Azines and their Biological Evaluation
Authors: Sophy Mohamed Ahmed Elian , Reheim Mohamed Ahmed Mahmoud Abdel 
Published: December 2022

Abstract

The present work deals with the synthesis of 2-cyano-N'-(3-(2-(2-cyanoacetyl) hydrazinyl) cyclohex-2-en-1-ylidene) acetohydrazide 3 that used as a key precursor in the manufacture of new heterocyclic derivatives, such as pyrazole, pyrane, pyridine and pyrole incorporating cyclohexene moiety via its reaction with a variety of nucleophilic and electrophilic reagents. The newly synthesized compounds were characterized by their elemental analyses (IR, 1H-NMR, 13C-NMR and Mass spectra) and assessed for their anti-microbial activity.
Chaos Gray Wolf global optimization algorithm based on Opposition- based Learning
Authors: Luo Zhiyong , Tan Mingxiang , Huang Zhengwen , Li Guoquan 
Published: December 2022

Abstract
Gray wolf optimizer (GWO) is a new heuristic algorithm. It has few parameters and strong optimization ability and is used in many fields. However, when solving complex and multimodal functions, it is also easy to trap into the local optimum and premature convergence. In order to boost the performance of GWO, a tent chaotic map and opposition-based learning Grey Wolf Optimizer (CO-GWO) is proposed. Firstly, some better values of the population in the current generation are retained to avoid deterioration in the next generation. Secondly, tent chaotic map and opposition-based(OBL)are introduced to generate values that can traverse the whole feasible region as much as possible, which is conducive to jumping out of local optimization and accelerating convergence. Then, the coefficient \(\vec {a}\) is dynamically adjusted by the polynomial attenuation function of the 2-decay method. Finally, the proposed algorithm is tested on 23 benchmark functions. The results show that the proposed algorithm is superior to the conventional heuristic algorithms, GWO and its variants in search-efficiency, solution accuracy and convergence rate.
Immune-related lncRNAs pairs prognostic score model for prediction of survival in acute myeloid leukemia patients
Authors: Liang Xue , Li Cong , Fan Mengmeng , Zhang Wanqiu , Liu Linlin , Zhou Ji , Hu Linhui , Zhai Zhimin 
Published: December 2022

Abstract
Acute myeloid leukemia (AML) is one of the most common malignant and aggressive hematologic tumors, and risk stratification is indispensable to ensure accurate treatment. But immune-related long noncoding RNAs (ir-lncRNAs) pairs prognostic risk model used to stratify AML has not been reported yet. In this study, we established an eight-pairs of ir-lncRNAs risk regression model by LASSO-penalized Cox regression analysis, and patients were divided into high-risk group and low-risk group based on their risk scores. High-risk patients presented more tumor mutation frequency, higher expression of human leukocyte antigen (HLA) related genes and immune checkpoint molecules. Gene Set Enrichment Analysis (GSEA) indicated that transforming growth factors β (TGFβ) pathway was activated in high-risk group, and we similarly found the expression of TGFβ1 was up-regulated and correlated with a poor prognosis in AML patients, exogenous TGFβ1 could also protect AML cells from apoptosis induced by chemotherapy. The ir-lncRNAs prognostic model contributes to predicting the prognosis of AML patients and providing valuable information about their response to immune checkpoint inhibitors. And increased TGFβ1 level resulting drug-resistant maybe one of main causes for treatment failure in high-risk patients.
Ethool, a tool to enable ethical and legal decision-making in research involving humans using new technologies in Europe: design and usability validation
Authors: Garzo Ainara , Garay-Vitoria Nestor 
Published: December 2022

Abstract

Human participation in technological research projects has become more frequent in recent years. However, most of the technological researchers who organize such experimentation are unaware about the various ethical and legal implications involved. Further, when it is a medical device prototype that is being evaluated, the ethical and legal implications may be even more complex. A review of the laws, standards and recommendations in Europe has been drawn up regarding human participation in new technology co-design, development and evaluation, focusing on technological research for assistive and medical devices. An easy-to-use tool, called Ethool, which acts as a guideline for European technological researchers has been designed and developed. In this manuscript, the iterative usability evaluation of Ethool is explained as well as the improvements made, following participants’ feedback. Ethool was rated as acceptable and usable by participants obtaining a SUS score of 93.0 in its last evaluation. The tool is currently available to be used by any interested parties with the aim of gathering additional feedback.
Stress Analysis of Leaf Spring Suspension System with The Combination of Helical Springs
Authors: Bhumarker Amit , Singh Abhishek 
Published: December 2022

Abstract
This study examines a modified leaf spring suspension system that was developed by combining two helical springs with the master leaf in order to improve the design of an existing leaf spring suspension system. To accomplish this, researchers are investigating the design and modeling of a semi-elliptical type mono-leaf spring on a light-weight compact truck. A helical spring is developed and created on both sides of this mono leaf, distanced equally from the leaf's center. In CATIA-V5R20, all modeling and analytic tasks are completed. Both theoretical and FEA methodologies are used to individually obtain the results of stress analyses under various loading conditions for the standard mono-leaf spring model and the proposed model with helical springs. Results indicate that using helical springs in combination with a master leaf reduces stress by an average of 8.3% for any loading condition. The present research has certain advantages that might undoubtedly optimize, stabilize, and make flexible the current leaf spring design for significantly improved performance and passenger comfort.
CURRENT KNOWLEDGE OF SCOLIOSIS IN PHYSIOTHERAPISTS AND PHYSIOTHERAPY STUDENTS TRAINED IN TURKEY
Authors: AKGÜL Hakan , KILIÇ Berivan Beril , SELÇUK Halit , SERMENLİ AYDIN Nimet , METE Emel , SARI Dilara Merve , DRAKE Shawn , KURU ÇOLAK Tuğba 
Published: December 2022

Purpose: Present evidence suggests that early detection and correct management is an essential
part of scoliosis treatment. Therefore, the physiotherapists and physiotherapy students must have
adequate knowledge of scoliosis. The purpose of this study was to evaluate the current knowledge of
physiotherapists and physiotherapy students in Turkey on scoliosis.
Methods: A previously designed questionnaire based on International Society on Scoliosis Orthopaedic
and Rehabilitation Treatment (SOSORT) guideline consists of two sections was used in this study.
The first section included eight questions to evaluate the knowledge level on the definition, cause,
development, prevalence, diagnosis, treatment, and bracing of scoliosis. The second section included
three multiple-choice questions to analyze the participants’ opinions on exercises for scoliosis. All
Turkish universities offering physiotherapy degrees and graduated physiotherapists from certain
social media groups were invited to participate in the study.
Results: 649 physiotherapists and 497 students completed the questionnaire. Scoliosis is recognized
as a 3-dimensional deformity of the spine by 39.8% of the students and 57.2% of the physiotherapists.
Only 19.5% of the students and 30.7% of the physiotherapists correctly identified the diagnostic
criteria for scoliosis. For therapeutic exercise, 48.7% of the students and 61.3% percent of the
physiotherapists identified the appropriate approach, and also 57.3% of the students and 62.6% of
the physiotherapists correctly identified the bracing recommendations.
Conclusion: Results of this study showed that physiotherapists and physiotherapy students do not
have sufficient knowledge of scoliosis. Action needs to be taken to improve the awareness and basic
knowledge level of scoliosis.
Evaluasi Kecernaan Komponen Serat Pelepah Sawit Dalam Ransum Ternak Ruminansia Secara In Vitro
Authors: Andayani Jul , Harnita Lucy , Kaswari Teja 
Published: December 2022

Tujuan dari penelitian ini adalah untuk mengetahui kecernaan in vitro komponen serat yaitu NDF, ADF dan Hemiselulosa pelepah sawit dalam ransum ternak ruminansia.
Rancangan percobaan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap dengan 5 perlakuan dan 4 ulangan, masing – masing perlakuan adalah A : 70% Hijauan (100% Rumput + 0% Pelepah Sawit) + 30% Konsentrat, B : 70% Hijauan (75% Rumput + 25% Pelepah Sawit) + 30% Konsentrat, C : 70% Hijauan (50% Rumput + 50% Pelepah Sawit) + 30% Konsentrat, D : 70% Hijauan (25% Rumput + 75% Pelepah Sawit) + 30% Konsentrat, dan E : 70% Hijauan (0% Rumput + 100% Pelepah Sawit) + 30% Konsentrat.
Hasil penelitian ini menunjukkan perlakuan berpengaruh nyata (P<0,05) terhadap kecernaan NDF, kecernaan ADF dan kecernaan Hemiselulosa.
Berdasarkan hasil penelitian dapat disimpulkan bahwa penggunaan pelepah sawit sebagai pakan ternak ruminansia dapat digunakan hanya sampai 25% menggantikan rumput dalam ransum.
A CALCULADORA COMO RECURSO DIDÁTICO PARA O ENSINO DOS NÚMEROS DECIMAIS
Authors: Sousa Jucá Rosineide de , Barros Neto Antonio José de , Franco de Sá Pedro 
Published: December 2022

Este trabalho teve por objetivo analisar se uma sequência de ensino usando a calculadora simples contribui para a compreensão do conceito e das propriedades dos números decimais. O caminho metodológico seguiu as quatros fases da Engenharia Didática: estudos preliminares, análise a priori, experimentação, análise a posteriori e validação. As atividades com a calculadora foram aplicadas aos alunos do 6º ano do ensino fundamental de uma escola pública de Belém do Pará e fazem parte da pesquisa de Jucá (2008). Os resultados apontaram que a calculadora contribuiu de forma favorável para a aprendizagem, possibilitando que os alunos se envolvessem em atividades de investigação para que compreendessem o conceito de números decimais e suas propriedades.
INTENSITAS KOMUNIKASI ORANGTUA DALAM MEMOTIVASI BELAJAR ANAK SEKOLAH DASAR DI DESA UNDAAN TENGAH
Authors: Meileni Hesti Rizki , Fajrie Nur , Setiawan Deka 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui intensitas komunikasi orang tua dalam memotivasi belajar anak sekolah dasar di Desa Undaan Tengah.Penelitian ini merupakan penelitian kualitatif deskriptif yang dilaksanakan di Desa Undaan tengah Kecamatan Undaan Kabupaten Kudus. Subyek penelitian yaitu siswa kelas V SD. Teknik pengumpulan data yang digunakan meliputi observasi, wawancara, dokumentasi dan pencatatan. Pengecekan keabsahan data menggunakan kredibilitas, transferabilitas, dependabilitas dan konfirmasibilitas. Analisis data yang digunakan yaitu reduksi data, penyajian data, penarikan kesimpulan/verifikasi data.. Hasil penelitian menunjukkan bahwa Intensitas komunikasi orang tua dalam memotivasi belajar berdasarkan tingkat pendidikan, pekerjaan hasilnya dua narasumber memiliki intensitas komunikasi yang tidak baik dan motivasi belajar yang rendah mereka adalah keluarga Ibu SN dan KI. Dua narasumber memiliki intensitas komunikasi yang baik dan motivasi belajar yang tinggi adalah keluarga Ibu SA dan MA. Faktor yang mempengaruhi intensitas komunikasi berdasarkan tingkat pendidikan dan pekerjaan yang berbeda yaitu keluarga ibu SN factor pekerjaan dan sikap pendiam anak, sementara keluarga ibu KI factor pekerjaan dan anak yang suka bermain game online. Untuk ibu SA dan ibu MA sama-sama dipengaruhi oleh pekerjaan akan tetapi walau mereka sibu tetap menyisihkan waktu untuk berkomunikasi dengan anaknya.
PENGARUH REWARD DAN PUNISHMENT TERHADAP MOTIVASI BELAJAR SISWA SD KELAS IV
Authors: Ummah Aniatul Khoirul , Ummah Aniatul Khoirul 
Published: December 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh reward dan punishment terhadap hasil belajar dan motivasi belajar siswa SDN 2 Ringin. Penelitian ini merupakan jenis penelitian kuantitatif dengan metode survei. Instrumen yang digunakan adalah lembar kuesioner berupa angket. Jenis angket yang digunakan adalah angket tertutup. Data yang dikumpulkan peneliti menggunakan wawancara dan kuesioner. Desain penelitian ini adalah Variabel bebas (Independen) dan Variabel terikat (Dependen). Populasi dalam penelitian ini pada kelas IV dengan jumlah 17 siswa. Sampling yang digunakan adalah teknik sampling jenuh karena jumlah siswa tidak terlalu banyak dan sesuai dengan kebutuhan penelitian. Pelaksanaan penelitian ini dilaksanakan di kelas IV SD Negeri 2 Ringin, Kecamatan Pamotan, Kabupaten Rembang, Jawa Tengah. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan antara Metode Reward (X1) terhadap Motivasi Belajar Siswa (Y) SDN 2 RINGIN. Terdapat pengaruh yang signifikan antara Metode Punishment (X2) terhadap Motivasi Belajar Siswa (Y) SDN 2 RINGIN. Terdapat pengaruh yang signifikan antara Metode Reward (X1) dan Metode Puishment (X2) secara bersama-sama terhadap Motivasi Belajar Siswa (Y) SDN 2 RINGIN.
ANALISIS MINAT BELAJAR SISWA PADA PEMBELAJARAN KELAS IV SDN JLEPER 01
Authors: Karisma Ega Tria , Setiawan Deka , Oktavianti Ika 
Published: December 2022

Penelitan ini bertujuan untuk menganalisis minat belajar kelas IV di SD N Jleper 1 pada pembelajaran luring.Objek penelitian ini siswa kelas IV SD N Jleper 1. Variable penelitian ini adalah Minat Belajar siswa.Metode Penelitian Yang digunakan dalam penelitian ini yaitu metode deskriptif kualitatif. Subjek penelitiannya adalah siswa kelas IV di SD N Jleper 1. Tehnik pengumpulan data yang digunakan observasi,wawancara, angket dan dokumentasi. Analisis data yang digunakan dalam penelitian ini menggunakan bentuk skoring.Hasil penelitian tingkat minat belajar siswa terhadap pelajaran Bahasa Indonesia di Sekolah Dasar Negeri Jleper 1 pada masa luring masih perlu mendapatkan perhatian yang lebih, baik dari guru (pendidik) dan lingkungan sekitarnya.Minat belajar siswa terhadap mata pelajaran Bahasa Indonesia pada siswa kelas IV SD Negeri Jleper 1 masih rendah. Diharapkan guru dan orang tua dapat memberikan dorongan motivasi dan perhatian kepada siswa.
ANALISIS KESALAHAN EJAAN DALAM PENULISAN KARANGAN DESKRIPSI SISWA KELAS IV SD 04 BESITO KUDUS
Authors: Herawati Indah , Kanzunnudin Mohammad 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui kesalahan ejaan dalam menulis karangan deskripsi yang dibuat oleh siswa. Penelitian ini menggunakan metode naratif kualitatif dengan pendekatan studi kasus yang dilakukan pada siswa kelas IV SD di Desa Besito Kecamatan Gebog Kabupaten Kudus. Teknik analisis data yang digunakan meliputi membaca, menandai atau mengidentifikasi, mengklasifikasikan data dan mendeskripsikan kesalahan. Hasil penelitian ini menunjukkan bahwa masih banyak siswa kelas IV SD 04 Besito yang melakukan kesalahan penggunaan huruf kapital dalam penggunaan ejaan, kesalahan penulisan kata depan dan terdapat kesalahan tanda titik pada akhir kalimat sedangkan kesalahan koma terdapat pada karangan siswa yang tidak memberikan tanda koma untuk memisahkan detail kata. Faktor penyebab kesalahan ejaan siswa yaitu kurangnya pengetahuan siswa dalam materi mengejaan, Cara guru mengurangi tingkat kesalahan ejaan siswa adalah dengan memberikan latihan menulis karangan, kemudian mengingatkan penggunaan ejaan sebelum menulis karangan dll
In Silico Study of Sesquiterpene and Monoterpene Compounds from Valerian Roots (Valerian officinalis) As Acetylcholinesterase Inhibitor
Authors: Prijadi Shannon Maidelaine , Aulia Safira , Afinasari Auliya , Aristawidya Levina , Syahrul Hikam Muhammad Dimas , Muchtaridi Muchtaridi 
Published: December 2022

Introduction: Alzheimer's is a central nervous system disease that can be treated with an acetylcholinesterase enzyme inhibitor drug (AChE), namely rivastigmine. Rivastigmine has side effects such as nausea, vomiting, loss of appetite, headache, weakness, and malaise. Alternative to deal with these side effects is an extracted compound from valerian root with bioactivity as an anti-dementia. The test compounds that performed the activity were 4 variations of sesquiterpenoids (volvalerenal H, volvalerenal I, volvalerenal J, volvalerenic acid K) and 1 monoterpenoid (densispicnins C). Objective: This study aimed to determine the molecular interaction of sesquiterpene and monoterpene compounds and pharmacokinetic of the best compound from molecular docking. Methods: This study was conducted with the stages of molecular docking simulation, prediction of pharmacokinetics and toxicity of compounds, and Lipinski’s Rule of Five parameters. Result: Volvalerenal J was the best compound from molecular docking simulation with a Gibbs free energy value of -7,48 kcal/mol, an inhibition constant of 1,30 μM, and interactions with amino acid residues His447 and Ser203. The values of HIA and CaCo2 were 100% and 46,76%, with the values of PPB and BBB were 96,57% and 0,88%. Respectively, volvalerenal J is not mutated but a carcinogen and fulfills the rules of Lipinski. Conclusion: Compound volvalerenal J has the highest potential to be the best acetylcholinesterase (AChE) inhibitor among other compounds in the extract valerian root.Keywords: AChE, Valerian Root, Alzheimer's, In silico
In Silico Study of Pertussis Toxin S1 for Recombinant Pertussis Vaccine Development in Indonesia
Authors: Rinaldi Ricky , Baroroh Umi , Rohmatulloh Fauzian Giansyah , Efendi Yusuf Sofyan , Novianti Mia Tria , Firdaus Ade Rizqy Ridwan , Subroto Toto , Yusuf Muhammad 
Published: December 2022

Pertussis or whooping cough is a disease caused by Bordetella pertussis bacteria, and the spread disease can be controlled by vaccination. Currently, some pertussis toxoids are prepared by chemical modification, which makes it possible to change the immunospecificity. To avoid altering the structure of toxoids, genetic modification is considered more harmless than chemical modification. A mutant of R9K/E129G is known to have lower toxicity and can be used as a component of the pertussis vaccine. However, the reason behind the low toxicity of this toxoid at the molecular level remains unclear. Hence, this study aimed to investigate the molecular mechanism behind the low toxicity of R9K/E129G using molecular dynamics simulation. The structure of the mutant was built using the homology modeling approach, and the behavior of wild-type and mutant toxoid were studied by molecular dynamics simulation for 300 ns. The changes in the structure in all systems were calculated by POVME, which was further investigated by molecular docking with NAD+ as the substrate. The results showed that the active site of the wild type was opened in the reducing environment while the mutant remained closed, which hindered the binding of NAD+. In conclusion, the dual mutation of R9K/E129G reduces pertussis toxoid's toxicity by preventing the catalytic site's opening. Therefore, this natural mutant can be further optimized in the development of a safer vaccine for pertussis. Keywords: Pertussis toxin, R9K/E129G mutant, molecular dynamics simulation, NAD+ binding site, vaccine.