bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory burden and persistent CT lung abnormalities in COVID-19 patients
Authors: Besutti Giulia , Giorgi Rossi Paolo , Ottone Marta , Spaggiari Lucia , Canovi Simone , Monelli Filippo , Bonelli Efrem , Fasano Tommaso , Sverzellati Nicola , Caruso Andrea , Facciolongo Nicola , Ghidoni Giulia , Simonazzi Anna , Iori Mauro , Nitrosi Andrea , Fugazzaro Stefania , Costi Stefania , Croci Stefania , Teopompi Elisabetta , Gallina Annalisa , Massari Marco , Dolci Giovanni , Sampaolesi Fabio , Pattacini Pierpaolo , Salvarani Carlo 
Published: March 2022

AbstractInflammatory burden is associated with COVID-19 severity and outcomes. Residual computed tomography (CT) lung abnormalities have been reported after COVID-19. The aim was to evaluate the association between inflammatory burden during COVID-19 and residual lung CT abnormalities collected on follow-up CT scans performed 2–3 and 6–7 months after COVID-19, in severe COVID-19 pneumonia survivors. C-reactive protein (CRP) curves describing inflammatory burden during the clinical course were built, and CRP peaks, velocities of increase, and integrals were calculated. Other putative determinants were age, sex, mechanical ventilation, lowest PaO2/FiO2 ratio, D-dimer peak, and length of hospital stay (LOS). Of the 259 included patients (median age 65 years; 30.5% females), 202 (78%) and 100 (38.6%) had residual, predominantly non-fibrotic, abnormalities at 2–3 and 6–7 months, respectively. In age- and sex-adjusted models, best CRP predictors for residual abnormalities were CRP peak (odds ratio [OR] for one standard deviation [SD] increase = 1.79; 95% confidence interval [CI] = 1.23–2.62) at 2–3 months and CRP integral (OR for one SD increase = 2.24; 95%CI = 1.53–3.28) at 6–7 months. Hence, inflammation is associated with short- and medium-term lung damage in COVID-19. Other severity measures, including mechanical ventilation and LOS, but not D-dimer, were mediators of the relationship between CRP and residual abnormalities.
Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy
Authors: Gautam Mukesh , Gunay Aksu , Chandel Navdeep S. , Ozdinler P. Hande 
Published: March 2022

AbstractMitochondrial defects result in dysregulation of metabolomics and energy homeostasis that are detected in upper motor neurons (UMNs) with TDP-43 pathology, a pathology that is predominantly present in both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). While same mitochondrial problems are present in the UMNs of ALS patients with TDP-43 pathology and UMNs of TDP-43 mouse models, and since pathologies are shared at a cellular level, regardless of species, we first analyzed the metabolite profile of both healthy and diseased motor cortex to investigate whether metabolomic changes occur with respect to TDP-43 pathology. High-performance liquid chromatography, high-resolution mass spectrometry and tandem mass spectrometry (HPLC–MS/MS) for metabolite profiling began to suggest that reduced levels of NAD+ is one of the underlying causes of metabolomic problems. Since nicotinamide mononucleotide (NMN) was reported to restore NAD+ levels, we next investigated whether NMN treatment would improve the health of diseased corticospinal motor neurons (CSMN, a.k.a. UMN in mice). prpTDP-43A315T-UeGFP mice, the CSMN reporter line with TDP-43 pathology, allowed cell-type specific responses of CSMN to NMN treatment to be assessed in vitro. Our results show that metabolomic defects occur early in ALS motor cortex and establishing NAD+ balance could offer therapeutic benefit to UMNs with TDP-43 pathology.
Clinical features and prognostic impact of asymptomatic pancreatic cancer
Authors: Takikawa Tetsuya , Kikuta Kazuhiro , Hamada Shin , Kume Kiyoshi , Miura Shin , Yoshida Naoki , Tanaka Yu , Matsumoto Ryotaro , Ikeda Mio , Kataoka Fumiya , Sasaki Akira , Nakagawa Kei , Unno Michiaki , Masamune Atsushi 
Published: March 2022

AbstractPancreatic ductal adenocarcinoma (PDAC) is highly lethal, and early diagnosis is challenging. Because patients who present with symptoms generally have advanced-stage diseases, analysis of asymptomatic PDAC provides invaluable information for developing strategies for early diagnosis. Here, we reviewed 577 patients with PDAC (372 diagnosed with symptoms [symptomatic group] and 205 without symptoms [asymptomatic group]) diagnosed at our institute. Among the 205 asymptomatic PDAC patients, 109 were detected during follow-up/work-up for other diseases, 61 because of new-onset or exacerbation of diabetes mellitus, and 35 in a medical check-up. Asymptomatic PDAC is characterized by smaller tumor size, earlier disease stage, and higher resectability than those of symptomatic PDAC. In 22.7% of asymptomatic cases, indirect findings, e.g., dilatation of the main pancreatic duct, triggered PDAC detection. Although pancreatic tumors were less frequently detected, overall abnormality detection rates on imaging studies were nearly 100% in asymptomatic PDAC. Asymptomatic PDAC had a better prognosis (median survival time, 881 days) than symptomatic PDAC (342 days, P < 0.001). In conclusion, diagnosis of PDAC in the asymptomatic stage is associated with early diagnosis and a better prognosis. Incidental detection of abnormal findings during the follow-up/work-up for other diseases provides important opportunities for early diagnosis of asymptomatic PDAC.
Pet-directed speech improves horses’ attention toward humans
Authors: Jardat Plotine , Calandreau Ludovic , Ferreira Vitor , Gouyet Chloé , Parias Céline , Reigner Fabrice , Lansade Léa 
Published: March 2022

AbstractIn a recent experiment, we showed that horses are sensitive to pet-directed speech (PDS), a kind of speech used to talk to companion animals that is characterized by high pitch and wide pitch variations. When talked to in PDS rather than adult-directed speech (ADS), horses reacted more favorably during grooming and in a pointing task. However, the mechanism behind their response remains unclear: does PDS draw horses’ attention and arouse them, or does it make their emotional state more positive? In this study, we used an innovative paradigm in which female horses watched videos of humans speaking in PDS or ADS to better understand this phenomenon. Horses reacted differently to the videos of PDS and ADS: they were significantly more attentive and their heart rates increased significantly more during PDS than during ADS. We found no difference in the expressions of negative or positive emotional states during PDS and ADS videos. Thus, we confirm that horses’ perception of humans can be studied by means of video projections, and we conclude that PDS attracts attention and has an arousing effect in horses, with consequences on the use of PDS in daily interactions with them.
Assessing the suitability of self-healing rubber glove for safe handling of pesticides
Authors: Supramaniam Janarthanan , Low Darren Yi Sern , Wong See Kiat , Goh Bey Hing , Leo Bey Fen , Tang Siah Ying 
Published: March 2022

AbstractRubber gloves used for protection against chemicals or hazards are generally prone to tearing or leaking after repeated use, exposing the worker to potentially hazardous agents. Self-healing technology promises increased product durability and shelf life appears to be a feasible solution to address these issues. Herein, we aimed to fabricate a novel epoxidized natural rubber-based self-healable glove (SH glove) and investigate its suitability for handling pesticides safely. In this study, breakthrough time analysis and surface morphological observation were performed to determine the SH glove’s ability to withstand dangerous chemicals. The chemical resistance performance of the fabricated SH glove was compared against four different types of commercial gloves at different temperatures. Using malathion as a model pesticide, the results showed that the SH glove presented chemical resistance ability comparable to those gloves made with nitrile and NR latex at room temperature and 37 °C. The self-healing test revealed that the SH glove could be self-healed and retained its chemical resistance ability close to its pre-cut value. Our findings suggested that the developed SH glove with proven chemical resistance capability could be a new suitable safety glove for effectively handling pesticides and reducing glove waste generation.
An emotional discrete controller PSO tuned and designed for a real industrial pumping system
Authors: Marques Davidson C. , Silva Jeydson L. , Lira Milde Maria S. , Aquino Ronaldo R. B. 
Published: March 2022

AbstractThe application of automation techniques to water pump systems, combined with modern control techniques, has been increasing the hydraulic and energy efficiency of such systems. In this context, the objective of this work is to present an intelligent method of flow control based on Brain Emotional Learning Basic Intelligent Control (BELBIC), which will be applied to an experimental workbench of a pumping system, located in the Energy Efficiency and Energy Quality Laboratory (LEEQE) at Federal University of Pernambuco (UFPE). The parameters of this controller are optimized with a particle swarm optimization (PSO) technique with minimization of Integral Absolute Error (IAE). Initial tests were performed in a computational environment so that the system’s performance could be pre-tested, thereby the dynamics of the system was modeled from real data generated in the process. The experimental results were obtained through the implementation of this control system in a programmable logic controller (PLC), which was the device responsible for all the automation of the workbench previously mentioned. The data of this workbench were collected using a supervisory system exclusively developed for this work. These data were then used to analyze the performance of the proposed control system, which demonstrated that its behavior was efficient.
Novel alleles gained during the Beringian isolation period
Authors: Niedbalski Sara D. , Long Jeffrey C. 
Published: March 2022

AbstractDuring the Last Glacial Maximum, a small band of Siberians entered the Beringian corridor, where they persisted, isolated from gene flow, for several thousand years before expansion into the Americas. The ecological features of the Beringian environment, coupled with an extended period of isolation at small population size, would have provided evolutionary opportunity for novel genetic variation to arise as both rare standing variants and new mutations were driven to high frequency through both neutral and directed processes. Here we perform a full genome investigation of Native American populations in the Thousand Genomes Project Phase 3 to identify unique high frequency alleles that can be dated to an origin in Beringia. Our analyses demonstrate that descendant populations of Native Americans harbor 20,424 such variants, which is on a scale comparable only to Africa and the Out of Africa bottleneck. This is consistent with simulations of a serial founder effects model. Tests for selection reveal that some of these Beringian variants were likely driven to high frequency by adaptive processes, and bioinformatic analyses suggest possible phenotypic pathways that were under selection during the Beringian Isolation period. Specifically, pathways related to cardiac processes and melanocyte function appear to be enriched for selected Beringian variants.
Environment and body-brain interplay affect inhibition and decision-making
Authors: Bouny Pierre , Trousselard Marion , Jacob Sandrine , Vialatte François , Verdonk Charles 
Published: March 2022

AbstractThe fine-tuned interplay of brain and body underlies human ability to cope with changes in the internal and external milieus. Previous research showed that cardiac interoceptive changes (e.g., cardiac phase) affect cognitive functions, notably inhibition that is a key element for adaptive behaviour. Here we investigated the influence on cognition of vestibular signal, which provides the brain with sensory information about body position and movement. We used a centrifuge-based design to disrupt vestibular signal in healthy human volunteers while their inhibition and decision-making functions were assessed with the stop-signal paradigm. Participants performed the standard and a novel, sensorial version of the stop-signal task to determine whether disrupted vestibular signal influences cognition as a function of its relevance to the context. First, we showed that disrupted vestibular signal was associated with a larger variability of longest inhibition latencies, meaning that participants were even slower to inhibit in the trials where they had the most difficulty inhibiting. Second, we revealed that processing of bodily information, as required in the sensorial stop-signal task, also led to a larger variability of longest inhibition latencies, which was all the more important when vestibular signal was disrupted. Lastly, we found that such a degraded response inhibition performance was due in part to the acceleration of decision-making process, meaning that participants made a decision more quickly even when strength of sensory evidence was reduced. Taken together, these novel findings provide direct evidence that vestibular signal affects the cognitive functions of inhibition and decision-making.
Universality and superiority in preference for chromatic composition of art paintings
Authors: Nakauchi Shigeki , Kondo Taisei , Kinzuka Yuya , Taniyama Yuma , Tamura Hideki , Higashi Hiroshi , Hine Kyoko , Minami Tetsuto , Linhares João M. M. , Nascimento Sérgio M. C. 
Published: March 2022

AbstractColor composition in paintings is a critical factor affecting observers’ aesthetic judgments. We examined observers’ preferences for the color composition of Japanese and Occidental paintings when their color gamut was rotated. In the experiment, observers were asked to select their preferred image from original and three hue-rotated images in a four-alternative forced choice paradigm. Despite observers’ being unfamiliar with the presented artwork, the original paintings (0 degrees) were preferred more frequently than the hue-rotated ones. Furthermore, the original paintings’ superiority was observed when the images were divided into small square pieces and their positions randomized (Scrambled condition), and when the images were composed of square pieces collected from different art paintings and composed as patchwork images (Patchwork condition). Therefore, the original paintings’ superiority regarding preference was quite robust, and the specific objects in the paintings associated with a particular color played only a limited role. Rather, the original paintings’ general trend in color statistics influenced hue-angle preference. Art paintings likely share common statistical regulations in color distributions, which may be the basis for the universality and superiority of the preference for original paintings.
Fructus Amomi extract attenuates nasal inflammation by restoring Th1/Th2 balance and down-regulation of NF-κB phosphorylation in OVA-induced allergic rhinitis
Authors: Fan Yanjing , Nguyen Thi Van , Piao Chun Hua , Shin Hee Soon , Song Chang Ho , Chai Ok Hee 
Published: March 2022

Abstract
Fructus Amomi Cardamomi (FA) is the mature fruit of Amomum villosum Lour (family Zingiberaceae) and is commonly used in Chinese traditional medicine to treat various gastrointestinal disorders. FA’s possible benefits as an allergic rhinitis (AR) treatment, however, have not been examined. We used an ovalbumin (OVA)-induced AR mouse model to identify any anti-allergic effects associated with the administration of 200 mg/kg FA or dexamethasone (Dex) 2.5 mg/kg by oral administration. The results of our testing confirm that FA ameliorated nasal symptoms and alleviated nasal epithelium swelling, reduced the goblet cell hyperplasia and eosinophil cell infiltration in the nasal epithelium, and inhibited lung tissue inflammation and Dex as well. Significantly decreased Th2 cytokine (interleukin (IL)-1β, IL-4, and IL-5) expression, and a correspondingly significant increase in Th1 cytokine (IL-12, interferon (IFN)-γ) production, was observed in nasal lavage fluid (NALF) taken from mice that received FA or Dex treatment. FA also reduced the presence of OVA-specific immunoglobulin (Ig) E, OVA-specific IgG1, and histamine levels in serum, and inhibited mast cell degranulation in vitro. In addition, these effects were involved with the reduction in NF-κB phosphorylation. These results suggest that FA restores Th1/Th2 balance and inhibits NF-κB phosphorylation and mast cell degranulation, thereby achieving a notable anti-inflammatory effect. Accordingly, it has the potential to be used as an efficacious therapeutic treatment for AR.
Improved two‐dimensional DOA estimation for three‐parallel nested arrays
Authors: Sun Fenggang , Wu Jiefang , Lan Peng 
Published: March 2022

AbstractAn improved two‐dimensional direction of arrival (DOA) estimation algorithm is proposed for three‐parallel nested arrays. To achieve a balanced estimation, array aperture is extended from two aspects, that is, virtual difference coarray construction of nested arrays and sparsely displaced parallel arrays. A new DOA extended matrix is formed by fully utilizing the auto‐covariance and cross‐covariance matrix among subarrays. Finally, a reduced dimensional estimation method is proposed without spectral search. Simulations verify the effectiveness of the proposed algorithm.
Accuracy study of linearization methods for quadratic cost curves of thermal units in unit commitment problems
Authors: Dong Jizhe , Li Yuanhan , Lu Yu , Han Shunjie 
Published: March 2022

AbstractTo solve the unit commitment (UC) problems with efficient mixed‐integer linear programming solvers, the quadratic cost functions (QCFs) of thermal units are always approximated to piecewise linear (PWL) functions. This study examines the accuracies of different approximation methods for piecewise linearizing the QCFs of units in UC problems. We use five piecewise linearization methods—evenly spaced PWL interpolation, evenly spaced PWL tangent, evenly spaced PWL–ɛmax/2 shifted interpolation, tighter PWL interpolation, and evenly spaced PWL least‐squares fit—to approximate the QCFs of units. The authors first perform a series of reproductivity studies to verify the program. Then, numerical tests are conducted using different methods on the systems with 10, 100, and 800 units. The results show that different approximation methods lead to considerable differences in operating costs and the tighter PWL interpolation, compared with the other methods, is preferred in terms of approximation accuracy.
Inverse design of a high‐quality factor multi‐purpose optical biosensor
Authors: Mafi Majid , Esmaile Amir Hosn 
Published: March 2022

AbstractThis paper investigates a high‐quality and multi‐purposed biosensor with maximum stable output transmittance numerically by using the inverse design method. The proposed biosensor utilises particle swarm optimisation for inverse design which will be a helpful way of designing different kinds of precise sensors in the future. In this research, some parameters are introduced to the optimiser to find the best cavity parameters for developing a high‐quality sensor to sense different targets. Many previous studies were on single‐goal biosensors, or their quality factor and output spectrum were very low. The proposed sensor can sense different parts of blood components, the amount of glucose in the urine, and tear's glucose for the first time just in one device to the best of our knowledge. Compared to previous works, this structure detects the differences between refractive indexes analytes with a high‐quality factor and a high and stable output transmittance spectrum. This structure contains two‐dimensional photonic crystal microresonators to provide resonance frequencies in the photonic bandgap. The device works on a window of 1.55 μm with a quality factor equal to 24,000, the sensitivity is 500 nm/RIU (refractive index unit), and the resolution is equal to 4 × 10−5. In this paper, the scaling method, particle swarm optimisation, two‐dimensional finite‐difference dime domain, and Plane‐Wave Expansion methods are utilised.
WD 1145+017: Alternative models of the atmosphere, dust clouds, and gas rings
Authors: Budaj J. , Maliuk A. , Hubeny I. 
Published: March 2022

Context. WD 1145+017 (WD1145) is the first white dwarf known to be orbited by disintegrating exoasteroids. It is a DBZ-type white dwarf with strongly variable broad circumstellar lines and variable shallow ultraviolet (UV) transits. Various models of the dust clouds and gaseous rings have been proposed as an explanation for this behavior.
Aims. We aim to revisit these observations and propose alternative or modified models of the atmosphere of this white dwarf, its dust clouds, and gas rings.
Methods. The simple radiative transfer code Shellspec was modified for this purpose and used for testing the new dust cloud and gas disk models. We used modified TLUSTY and SYNSPEC codes to calculate atmosphere models assuming the local thermodynamical equilibrium (LTE) or nonLTE (NLTE), and to calculate the intrinsic spectrum of the star. We then used these atmosphere models to estimate the mass of the radiative and convective zones and NLTE spectrum synthesis to estimate their chemical composition.
Results. We offer an alternative explanation of some (not all) shallow UV transits. These may be naturally caused by the optical properties of the dust grains: opacities and mainly phase functions as a result of the forward scattering. The latter is much stronger in UV compared to the optical region, leaving more UV photons in the original direction during the transit. We also developed an alternative model of the gaseous disk, consisting of an inner, hotter, and almost circular disk and an outer, cooler, and eccentric disk. The structure precesses with a period of 3.83 ± 0.12 yr. We demonstrate that it fits the observed circumstellar lines reasonably well. These alternative models solve a few drawbacks that might be associated with the previous models, but they also have their own disadvantages. We confirm that the chemical composition of the atmosphere is similar to that of CI chondrites but carbon, nitrogen, and sulfur are significantly underabundant and much closer to the bulk Earth composition. This is a strong argument that the star has recently encountered and accreted material from a body of Earth-like composition.