bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAMC2 as a prognostic biomarker in human cancer: a systematic review and meta-analysis
Authors: Fu Tao , Liu Jun-Xia , Xie Juan , Gao Zhen , Yang Zhenshan 
Published: November 2022

ObjectivesAccumulating evidence suggested that the laminin γ2 (LAMC2) expression level was upregulated in various cancers. However, the potential prognostic value of LAMC2 in cancers remains unclear. We conducted a meta-analysis to clarify the association of LAMC2 expression with prognosis.DesignWe searched Embase, Web of Science and PubMed (up to 25 November 2021) to collect all eligible studies, and meta-analysis was performed to interpret the association of LAMC2 expression with clinicopathological parameters, overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS).Eligibility criteria for including studiesWe included studies that investigate the relationship between LAMC2 and prognosis of cancers, patients were divided into two groups, and associations of LAMC2 expression with clinicopathological features were described.ResultsSeven studies were finally included. We found that increased LAMC2 expression was significantly associated with lymph node metastasis (log OR 0.88, 95% CI 0.38 to 1.38, p<0.001), tumour-node-metastasis stages (log OR: 0.95, 95% CI 0.39 to 1.50, p<0.001) and tumour status (log OR 1.26, 95% CI 0.84 to 1.68, p<0.001), but not with age (log OR −0.05, 95% CI −0.37 to 0.27, p=0.75) or gender (log OR −0.07, 95% CI −0.52 to 0.38, p=0.75). In addition, higher LAMC2 expression was found to be significantly associated with OS/PFS/DSS (HR 1.85, 95% CI 1.31 to 2.40, p<0.001). A similar result was found in The Cancer Genome Atlas database. High LAMC2 expression was significantly associated with OS in lung adenocarcinoma, mesothelioma, skin cutaneous melanoma, neck squamous cell carcinoma and brain lower grade glioma.ConclusionOur results suggested that higher LAMC2 expression was correlated with worse survival, lymph node metastasis, tumour-node-metastasis stages and tumour status. This study was subject to inherent limitations, but the results presented here provide insights regarding the potential use of LAMC2 as a biomarker for human cancer.Study registrationresearchregistry.com (researchregistry1319).
Discussing results of patient-reported outcome measures (PROMs) between patients and healthcare professionals in routine dialysis care: a qualitative study
Authors: van der Willik Esmee M , Milders Jet , Bart Johannes A J , Bos Willem Jan W , van Ittersum Frans J , ten Dam Marc A G J , Hemmelder Marc H , Dekker Friedo W , Meuleman Yvette 
Published: November 2022

ObjectivesPatient-reported outcome measures (PROMs) provide insight into patients’ experienced health and needs, and can improve patient–professional communication. However, little is known about how to discuss PROM results. This study aimed to provide in-depth knowledge of patients’ and healthcare professionals’ experiences with and perspectives on discussing PROM results as part of routine dialysis care.DesignA qualitative study was performed using an interpretive description approach. Individual semistructured interviews were conducted with 22 patients and healthcare professionals. Interviews focused on general and specific situations (eg, addressing sensitive topics or when no medical treatment is available). Interviews were transcribed verbatim and analysed inductively using thematic analysis.SettingParticipants were purposively sampled from eight dialysis centres across the Netherlands.ParticipantsInterviews were conducted with 10 patients receiving dialysis treatment and 12 healthcare professionals (nephrologists and nurses).ResultsPatients and healthcare professionals provided practical guidance for optimal discussion about PROM results. First, patients and healthcare professionals emphasised that PROM results should always be discussed and indicated how to create a suitable setting, adequately prepare, deal with time constraints and use PROMs as a tool for personalised holistic consultations. Second, patients should actively participate and healthcare professionals should take a guiding role. A trusting patient–professional relationship was considered a prerequisite and patient–professional interaction was described as a collaboration in which both contribute their knowledge, experiences and ideas. Third, follow-up after discussing PROM results was considered important, including evaluations and actions (eg, symptom management) structurally embedded into the multidisciplinary treatment process. These general themes also applied to the specific situations, for example: results should also be discussed when no medical treatment is available. Though, healthcare professionals were expected to take more initiative and a leading role when discussing sensitive topics.ConclusionsThis study provides insight into how to organise and conduct conversations about PROM results and lays the foundation for training healthcare professionals to optimally discuss PROM results in routine nephrology care. Further research is needed to provide guidance on follow-up actions in response to specific PROM results.
Hemorrhage rates in patients with acute ischemic stroke treated with intravenous alteplase and thrombectomy versus thrombectomy alone
Authors: van Kranendonk Katinka R , Kappelhof Manon , Bruggeman Agnetha A E , Rinkel Leon A , Treurniet Kilian M , LeCouffe Natalie , Emmer Bart J , Coutinho Jonathan M , Wolff Lennard , van Zwam Wim H , van Oostenbrugge Robert J , van der Lugt Aad , Dippel Diederik W J , Roos Yvo B W E M , Marquering Henk A , Majoie Charles B L M 
Published: November 2022

BackgroundIntravenous alteplase treatment (IVT) for acute ischemic stroke carries a risk of intracranial hemorrhage (ICH). However, reperfusion of an occluded vessel itself may contribute to the risk of ICH. We determined whether IVT and reperfusion are associated with ICH or its volume in the Multicenter Randomized Clinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands (MR CLEAN)-NO IV trial.MethodsThe MR CLEAN-NO IV trial randomized patients with acute ischemic stroke due to large vessel occlusion to receive either IVT followed by endovascular treatment (EVT) or EVT alone. ICH was classified according to the Heidelberg bleeding classification on follow-up MRI or CT approximately 8 hours−7 days after stroke. Hemorrhage volume was measured with ITK-snap. Successful reperfusion was defined as extended Thrombolysis In Cerebral Infarction (eTICI) score of 2b-3. Multinomial and binary adjusted logistic regression were used to determine the association of IVT and reperfusion with ICH subtypes.ResultsOf 539 included patients, 173 (32%) developed ICH and 30 suffered from symptomatic ICH (sICH) (6%). Of the patients with ICH, 102 had hemorrhagic infarction, 47 had parenchymal hematoma, 44 had SAH, and six had other ICH. Reperfusion was associated with a decreased risk of SAH, and IVT was not associated with SAH (eTICI 2b-3: adjusted OR 0.45, 95% CI 0.21 to 0.97; EVT without IVT: OR 1.6, 95% CI 0.91 to 2.8). Reperfusion status and IVT were not associated with overall ICH, hemorrhage volume, and sICH (sICH: EVT without IVT, OR 0.96, 95% CI 0.41 to 2.25; eTICI 2b-3, OR 0.49, 95% CI 0.23 to 1.05).ConclusionNeither IVT administration before EVT nor successful reperfusion after EVT were associated with ICH, hemorrhage volume, and sICH. SAH occurred more often in patients for whom successful reperfusion was not achieved.
Association of intravenous thrombolysis and pre-interventional reperfusion: a post hoc analysis of the SWIFT DIRECT trial
Authors: Mujanovic Adnan , Eker Omer , Marnat Gaultier , Strbian Daniel , Ijäs Petra , Préterre Cécile , Triquenot Aude , Albucher Jean François , Gauberti Maxime , Weisenburger-Lile David , Ernst Marielle , Nikoubashman Omid , Mpotsaris Anastasios , Gory Benjamin , Tuan Hua Vi , Ribo Marc , Liebeskind David S , Dobrocky Tomas , Meinel Thomas R , Buetikofer Lukas , Gralla Jan , Fischer Urs , Kaesmacher Johannes 
Published: November 2022

BackgroundA potential benefit of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) is pre-interventional reperfusion. Currently, there are few data on the occurrence of pre-interventional reperfusion in patients randomized to IVT or no IVT before MT.MethodsSWIFT DIRECT (Solitaire With the Intention For Thrombectomy Plus Intravenous t-PA vs DIRECT Solitaire Stent-retriever Thrombectomy in Acute Anterior Circulation Stroke) was a randomized controlled trial including acute ischemic stroke IVT eligible patients being directly admitted to a comprehensive stroke center, with allocation to IVT with MT versus MT alone. The primary endpoint of this analysis was the occurrence of pre-interventional reperfusion, defined as a pre-interventional expanded Thrombolysis in Cerebral Infarction score of ≥2a. The effect of IVT and potential treatment effect heterogeneity were analyzed using logistic regression analyses.ResultsOf 396 patients, pre-interventional reperfusion occurred in 20 (10.0%) patients randomized to IVT with MT, and in 7 (3.6%) patients randomized to MT alone. Receiving IVT favored the occurrence of pre-interventional reperfusion (adjusted OR 2.91, 95% CI 1.23 to 6.87). There was no IVT treatment effect heterogeneity on the occurrence of pre-interventional reperfusion with different strata of Randomization-to-Groin-Puncture time (p for interaction=0.33), although the effect tended to be stronger in patients with a Randomization-to-Groin-Puncture time >28 min (adjusted OR 4.65, 95% CI 1.16 to 18.68). There were no significant differences in rates of functional outcomes between patients with and without pre-interventional reperfusion.ConclusionEven for patients with proximal large vessel occlusions and direct access to MT, IVT resulted in an absolute increase of 6% in rates of pre-interventional reperfusion. The influence of time strata on the occurrence of pre-interventional reperfusion should be studied further in an individual patient data meta-analysis of comparable trials.Trial registration numberclinicaltrials.govNCT03192332.
Society of NeuroInterventional Surgery: position statement on pregnancy and parental leave for physicians practicing neurointerventional surgery
Authors: Baker Amanda , Narayanan Sandra , Tsai Jenny P , Tjoumakaris Stavropoula I , Haranhalli Neil , Fraser Justin F , Hetts Steven W ,   SNIS Standards and Guidelines Committee
Published: November 2022

BackgroundThe aim of this article is to outline a position statement on pregnancy and parental leave for physicians practicing neurointerventional surgery.MethodsWe performed a structured literature review regarding parental leave policies in neurointerventional surgery and related fields. The recommendations resulted from discussion among the authors, and additional input from the Women in NeuroIntervention Committee, the full Society of NeuroInterventional Surgery (SNIS) Standards and Guidelines Committee, and the SNIS Board of Directors.ResultsSome aspects of workplace safety during pregnancy are regulated by the US Nuclear Regulatory Commission. Other aspects of the workplace and reasonable job accommodations are legally governed by the Family and Medical Leave Act of 1993, the Affordable Care Act of 2010 and the Fair Labor Standards Act of 1938, Americans with Disabilities Act of 1990, Title IX of the Education Amendments of 1972, Title VII of the Civil Rights Act of 1964 as well as rights and protections put forth by the Occupational Safety and Health Administration as part of the United States Department of Labor. Family friendly policies have been associated not only with improved job satisfaction but also with improved parental and infant outcomes. Secondary effects of such accommodations are to increase the number of women within the specialty.ConclusionsSNIS supports a physician’s ambition to have a family as well as start, develop, and maintain a career in neurointerventional surgery. Legal and regulatory mandates and family friendly workplace policies should be considered when institutions and individual practitioners approach the issue of childbearing in the context of a career in neurointerventional surgery.
Retinal toxicity in a multinational inception cohort of patients with systemic lupus on hydroxychloroquine
Authors: Almeida-Brasil Celline C , Hanly John G , Urowitz Murray , Clarke Ann Elaine , Ruiz-Irastorza Guillermo , Gordon Caroline , Ramsey-Goldman Rosalind , Petri Michelle A , Ginzler Ellen M , Wallace Daniel J , Bae Sang-Cheol , Romero-Diaz Juanita , Dooley Mary-Anne , Peschken Christine , Isenberg David , Rahman Anisur , Manzi Susan , Jacobsen Søren , Lim S Sam , van Vollenhoven Ronald , Nived Ola , Jönsen Andreas , Kamen Diane L , Aranow Cynthia , Sánchez-Guerrero Jorge , Gladman Dafna D , Fortin Paul R , Alarcon Graciela S , Merrill Joan T , Kalunian Kenneth , Ramos-Casals Manuel , Steinsson Kristjan , Zoma A , Askanase Anca D , Khamashta Munther , Bruce Ian N , Inanc Murat , Lukusa Luck , Bernatsky Sasha 
Published: November 2022

ObjectiveTo evaluate hydroxychloroquine (HCQ)-related retinal toxicity in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort.MethodsData were collected at annual study visits between 1999 and 2019. We followed patients with incident SLE from first visit on HCQ (time zero) up to time of retinal toxicity (outcome), death, loss-to-follow-up or end of study. Potential retinal toxicity was identified from SLICC Damage Index scores; cases were confirmed with chart review. Using cumulative HCQ duration as the time axis, we constructed univariate Cox regression models to assess if covariates (ie, HCQ daily dose/kg, sex, race/ethnicity, age at SLE onset, education, body mass index, renal damage, chloroquine use) were associated with HCQ-related retinal toxicity.ResultsWe studied 1460 patients (89% female, 52% white). Retinal toxicity was confirmed in 11 patients (incidence 1.0 per 1000 person-years, 0.8% overall). Average cumulative time on HCQ in those with retinal toxicity was 7.4 (SD 3.2) years; the first case was detected 4 years after HCQ initiation. Risk of retinal toxicity was numerically higher in older patients at SLE diagnosis (univariate HR 1.05, 95% CI 1.01 to 1.09).ConclusionsThis is the first assessment of HCQ and retinal disease in incident SLE. We did not see any cases of retinopathy within the first 4 years of HCQ. Cumulative HCQ may be associated with increased risk. Ophthalmology monitoring (and formal assessment of cases of potential toxicity, by a retinal specialist) remains important, especially in patients on HCQ for 10+ years, those needing higher doses and those of older age at SLE diagnosis.
Strange Quark Star (SQS) in Tolman IV potential with density dependent B-parameter and charge
Authors: Goswami K. B. , Roy R. , Saha A. , Chattopadhyay P. K. 
Published: November 2022

AbstractIn this paper, the solutions of Einstein–Maxwell Field Equations for relativistic strange quark star in Tolman-IV potential considering MIT bag model EoS $$p=\frac{1}{3}(\rho -4B)$$

p
=

1
3

(
ρ
-
4
B
)

of interior matter in presence of charge in higher dimensions is presented, where B is bag parameter. Here we consider density dependent B as it has more practical application. We note some interesting results. It is observed that interior of a strange quark star may contain bulk stable quarks as a whole having energy per baryon $$E_B<930.4$$

E
B

<
930.4

MeV/fm$$^3$$

3

or stable quark matter core enclosed by a thin metastable quark matter layer enveloped by unstable quark matter. It is also found that interior composition depends on the value of space-time dimension (D) and net charge (Q). The model presented in this paper satisfies all the necessary stability and energy conditions for a viable stellar configuration. We also note the maximum mass of stable strange quark star is 1.773 $$M_{\odot }$$

M
⊙

for density dependent B and 1.684 $$M_{\odot }$$

M
⊙

for constant B.
Trade synchronization and social ties in stock markets
Authors: Baltakienė Margarita , Baltakys Kęstutis , Kanniainen Juho 
Published: November 2022

AbstractPrevious studies suggest that individuals sharing similar characteristics establish stronger social relationships. This motivates us to examine what combinations of socioeconomic investor attributes are more likely to be associated with joint trading behavior. We use a unique data set on actual social ties between investors and find that similarities in investors’ age, geographical location, or length of the co-employment can affect trade synchronization under certain circumstances. Our findings have implications for the analysis of investor networks.
Analyzing effectiveness of service quality in Tirupattur post office toward postal life insurance (PLI) and rural postal life insurance (RPLI)
Authors: Rasadurai Dakshayini , Raguraman M. 
Published: November 2022

Purpose: This paper aims to analyze the effectiveness of service quality provided in Tirupattur Head Post Office toward Postal Life Insurance (PLI) and Rural Postal Life Insurance (RPLI) polices. Service quality is an important element in the management of service. The post office is a very big service-oriented institution. It started its insurance business from 1 February 1884. Design, methodology, approach: A descriptive research design were used to study the objective such as analyzing the various service quality provided by Postal Insurer and also to find the best service quality, to achieve this the researcher used questionnaire to collect 85 samples using simple random technique from PLI and RPLI policyholders in Tirupattur district. The primary data are analyzed by applying percentage analysis, mean and standard deviation, [Formula: see text]-test and [Formula: see text]-test in SPSS tools. Finding: A finding of the study shows that postal insurance industry was providing high quality services regarding financial stability accessible location, flexible payments and were providing low quality services regarding online transaction, approaching from the customers point of view, introducing new products. Mean and SD value show positive rating. The [Formula: see text]-test shows the assurance is the best service quality provided by postal insurer among six service quality factors. All the service quality statements are above average level. [Formula: see text]test shows a significant difference of all statement if service quality factors to demographic factors. Practical implications: This research paper is important for the investors, postal insurer, and post office. Service quality will have positive impact on customer satisfaction that will lead to investment behavior. Social implications: This study provides awareness to investors about postal insurance, important of service quality to the postal insurer, in the study area and trends-related research for future. Originality: This study provides a comprehensive review of theories, methods, discussion points, and conclusions of studies on service quality, customer satisfaction, PLI published in selected investment journals over past 20 years. Research limitations: This study was confined only to Tirupattur Head Post Office and Conclusions drawn may not be applicable to other district post office and, therefore, the findings of this study cannot be generalized.
Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications
Authors: Nayor Matthew , Gajjar Priya , Murthy Venkatesh L. , Miller Patricia E. , Velagaleti Raghava S. , Larson Martin G. , Vasan Ramachandran S. , Lewis Gregory D. , Mitchell Gary F. , Shah Ravi V. 
Published: November 2022

Background:
Abnormal blood pressure (BP) responses to exercise can predict adverse cardiovascular outcomes, but their optimal measurement and definitions are poorly understood. We combined frequently sampled BP during cardiopulmonary exercise testing with vascular stiffness assessment to parse cardiac and vascular components of exercise BP.

Methods:

Cardiopulmonary exercise testing with BP measured every two minutes and resting vascular tonometry were performed in 2858 Framingham Heart Study participants. Linear regression was used to analyze sex-specific exercise BP patterns as a function of arterial stiffness (carotid-femoral pulse wave velocity) and cardiac-peripheral performance (defined by peak O
2
pulse).

Results:

Our sample was balanced by sex (52% women) with mean age 54±9 years and 47% with hypertension. We observed variability in carotid-femoral pulse wave velocity and peak O
2
pulse across individuals with clinically defined exercise hypertension (peak systolic BP [SBP] in men ≥210 mm Hg; in women ≥190 mm Hg). Despite similar resting SBP and cardiometabolic profiles, individuals with higher peak O
2
pulse displayed higher peak SBP (
P
≤0.017) alongside higher fitness levels (
P
<0.001), suggesting that high peak exercise SBP in the context of high peak O
2
pulse may in fact be favorable. Although both higher (favorable) O
2
pulse and higher (adverse) arterial stiffness were associated with greater peak SBP (
P
<0.0001 for both), the magnitude of association of carotid-femoral pulse wave velocity with peak SBP was higher in women (sex–carotid-femoral pulse wave velocity interaction
P
<0.0001). In sex-specific models, exercise SBP measures accounting for workload (eg, SBP during unloaded exercise, SBP at 75 watts, and SBP/workload slope) were directly associated with the adverse features of greater arterial stiffness and lower peak O
2
pulse.

Conclusions:
Higher peak exercise SBP reflects a complex trade-off between arterial stiffness and cardiac-peripheral performance that differs by sex. Studies of BP responses to exercise accounting for vascular and cardiac physiology may illuminate mechanisms of hypertension and clarify clinical interpretation of exercise BP.
Australia’s fiscal surplus: Child of a credit and real estate boom
Authors: Espinosa Eduardo Garzón , García Bibiana Medialdea , Hidalgo Esteban Cruz , Mato Carlos Sánchez 
Published: November 2022

AbstractFor several years leading up to the 2008 financial crisis, Australia registered a public surplus, and this was generally interpreted as the result of responsible fiscal policy. However, since the outbreak of that crisis, no such fiscal balance has again been attained, giving rise to a range of explanations from the political incapacity of governments to the weak economic behaviour characterising the post-crisis era. Noteworthy in any case is that analysts have failed to cite the importance of a factor that was key to reaching pre-crisis surpluses: the vertiginous growth of private debt. This work argues that it was precisely the intense granting of bank loans and consequent increased demand from the private sector that boosted economic activity and led to the generation of public income sufficient to feed the fiscal surpluses of that period. Indeed, according to the proposals of Wynne Godley, this would have been the only way to register a public surplus in a context of current account deficits, typical of the Australian economy. This paper considers whether Australian private debt played a significant role in achieving fiscal surplus by way of a review of the Australian real estate boom and public accounts from the 1990s onward, also estimating an econometric model of autoregressive vectors to explore the link between these two variables. The results obtained appear to corroborate the hypothesis: severe private borrowing contributed to Australia’s fiscal surpluses. This finding has significant implications for budgetary policy.