bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health status of older people in slums of Bangladesh: A cross-sectional study in Khulna city corporation
Authors: Nusrat Jahan , Dipika Chandra , Afsana Polly , Shahinur Akter , Akter Heme Morsheda , Laila Siddiqua , Rumana Rahman , Fatima Mohsin Kaniz , Ta Hossain Md. 
Published: July 2022

Abstract
BackgroundThe world is experiencing a demographic change – an explosion of the elderly population. However, the growing elderly population also poses a significant challenge for the government to ensure universal healthcare as people are physically and mentally vulnerable, especially in old age. This study, therefore, aimed to explore the health problems of the elderly among urban slum dwellers and identify the associated risk factors.MethodsThis cross-sectional study was carried out in four slums of Bangladesh’s Khulna city corporation (KCC). Data were randomly collected from 636 elderly individuals by administering a semi-structured interview schedule. Data were analyzed using IBM SPSS Statistics (version 26), and both bivariate [Pearson’s Chi-square (χ2) and Yate’s continuity correction (χ2Yate’s)] and multivariate (multivariable logistic regression) tests were executed.ResultsFindings indicate that 80 or above aged people were more prone to infirmity (AOR = 2.263, p < 0.01) than their younger counterparts, while people with relatively more education (AOR = 0.640, p <0.05) and better income (AOR = 0.503, p < 0.10) were less likely to be sick, respectively. Surprisingly, married elderly was also found to be sick (AOR = 2.443, p < 0.05) more than widow/divorced older adults. Meanwhile, older people capable of doing daily activities were prone to health problems (AOR = 1.077; p < 0.10), whereas people with higher life satisfaction were less vulnerable to sickness (AOR = 0.858; p < 0.01).ConclusionTo ensure universal healthcare coverage, particularly in urban areas and their slums, improving the financial and social protection mechanisms for the older people in Bangladesh is strongly recommended. Besides, policymakers should also emphasize family cohesion to support the elderly emotionally and financially when they are vulnerable.
Serotonin-releasing agents with reduced off-target effects
Authors: Mayer Felix P , Niello Marco , Cintulova Daniela , Sideromenos Spyridon , Maier Julian , Li Yang , Bulling Simon , Kudlacek Oliver , Schicker Klaus , Iwamoto Hideki , Deng Fei , Wang Jinxia , Holy Marion , Katamish Rani , Sandtner Walter , Li Yulong , Pollak Daniela , Blakely Randy D , Mihovilovic Marko , Baumann Michael H , Sitte Harald H 
Published: July 2022

Abstract
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g. social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studies established the potential of drugs inducing the release of 5-HT via the 5-HT-transporter. Nevertheless, current 5-HT releasing compounds under clinical investigation carry the risk for abuse and deleterious side effects. Here, we demonstrate that S-enantiomers of certain ring-substituted cathinones show preference for the release of 5-HT ex vivo and in vivo, and exert 5-HT-associated effects in preclinical behavioral models. Importantly, the lead cathinone compounds (i) do not induce substantial dopamine release and (ii) display reduced off-target activity at vesicular monoamine transporter-2 and 5-HT2B-receptors; indicative of low abuse-liability and low potential for adverse events. Taken together, our findings identify these agents as first-in class leads that may prove useful for the treatment of disorders where elevation of 5-HT has proven beneficial.
Technological approaches to the extraction and purification by ultrafiltration techniques of target protein molecules from animal tissues: a review
Authors: Kotenkova E. A. , Polishchuk E. K. 
Published: July 2022

Effective isolation and purification of protein is a great challenge nowadays. The key aspect is protein stability and solubility, which primarily depend on protein structure and its amino acid sequence. Manipulations with pH and ionic strength are the first at tempts to increase protein stability and solubility. Different additives that are allowed or prohibited in the food industry are applied for overcoming protein aggregation. Sugars, polyhydric alcohols and amino acids are the most attractive among them. Trehalose, glycerol, arginine, glycine and proline demonstrated outstanding properties that make them perspective for application during iso lation and purification of proteins singly or in combination with each other or othercompounds. However, the algorithm of effective isolation and purification of protein could be significantly varied depending on its structure.
ANALISIS PENGARUH SUKU BUNGA SERTIFIKAT BANK INDONESIA DAN JUMLAH UANG BEREDAR TERHADAP TINGKAT INFLASI DI INDONESIA PERIODE 2006.1-2015.12 (PENDEKATAN ERROR CORRECTION MODEL)
Authors: Rahmawati D.A. Dwi , Riyanto Wahyu Hidayat 
Published: July 2022

Prominent characteristics of the direction economic policy in Asia is the emphasis on the inflation rate. Inflation is defined as a condition increases the price of prevailing goods in an economy continuously. The purpose of this research is to find out and analyze the influence of Bank Indonesia Certificate interest rate and money supply toward the inflation rate in Indonesia. This research method using time series of monthly data during the period of the 2006.1-2015.12 model approach using error correction (ECM) in the long term or short term. The results of the estimation of cointegration equation indicate that on the long run variable Bank Indonesia Certificate interest rate and money supply is significantly effected by to the inflation rate in Indonesia. While ECM model is considered valid because the error correction term (ECT) has significant value. In the short term only Bank Indonesia Certificate interest rates that influence significantly to the inflation rate in Indonesia. Keywords: inflation, interest rates, money supply, error correction model
Analisis Kelimpahan Dan Indeks Saprobitas Fitoplankton Pada Ekosistem Padang Lamun Di Pantai Sindhu, Sanur, Bali
Authors: Sang Ayu Made Putri Suryani  , Laras Syahrani  , I Wayan Arya  
Published: July 2022

Abstract
Sindhu Beach is one of the beaches in the Sanur area that is used for various economic activities, such as recreational locations or marine tourism by involving many stakeholders that can affect the aquatic environment which is the habitat of marine biota, is phytoplankton. In addition, the presence of seagrass also affects the abundance and saprobity index of phytoplankton. The research was conducted in May 2021 at Sindhu Beach and the identification process was carried out in the laboratory of the Faculty of Agriculture, Warmadewa University. The method used is the descriptive method. There were 20 types of phytoplankton from five classes, namely Chlorophyceae, Diatomae, Bacillariophyceae, Cyanophyceae, and Dinophyceae classes. The highest abundance of phytoplankton in the third observation was 206.369 ind/l at Station 1 and the lowest at the third observation was 152.866 ind/l at Station 2. At Station 1, the lowest water saprobic index was 0.047 in the first observation, followed by the second observation at 0.130, and the highest at the observation third at 0.307. This value is included in the moderately polluted category. At Station 2, the lowest water saprobic index in the first observation was -0.538, followed by the second observation at 0.28 and the highest at the third observation at 0.523. This value is included in the category of lightly polluted. At Station 3, the lowest water saprobic index in the first observation was 0.307, followed by the second observation at 0.615 and the highest at 0.739. This value is included in the category of lightly polluted.
Penambahan Carboxymethyle Cellulosa (CMC) Dan Lama Penyimpanan Pada Suhu Dingin Terhadap Karakteristik Susu Kacang Merah
Authors: Richard Randi  , I Wayan Sudiarta  , I Nyoman Rudianta  
Published: July 2022

Local nuts are an alternative source of vegetable protein that is cheap and affordable by the people of Indonesia. Peanuts whose potential has not been fully explored, including red beans, green beans, and cowpeas are types of beans that have the potential to be developed in various products of the food industry (Fachrudin, 2009). One type of legume that is very good for consumption is red beans. This study aims to determine the addition (CMC) and storage time at cold temperature to the characteristics of red bean milk. The research design used a completely randomized design (CRD) factorial pattern with two factors and two replications, namely factor I was the addition of CMC treatment consisting of 4 levels, namely: (0.04%), (0.06%), (0.08 %), (0.10%). Factor Il is the treatment of shelf life which consists of 4 levels, namely: 0 days, 3 days, 6 days, and 9 days. Observations were carried out objectively including: moisture content, ash content, fat content, protein content, carbohydrates, viscosity, pH and color. Meanwhile, subjective observations include: color, aroma, taste, texture and overall acceptance. The best research results were obtained in the treatment with the addition of 0.06% CMC and storage time on day 3, with the results of 91.82% moisture content, 0.64% ash content, 1.92% fat content, 3.09 protein content. %, carbohydrate content of 2.73%, viscosity 29.75%, pH level of 6.57%, and subjectively have the highest preference for panelists
Factors Associated with Long-Term COVID-19: An Observational Cross-Sectional Study in Indonesia
Authors: Puspitasari Arina Dery , Ardianto Nanda , Aina Lily , Kundiman Eunice Marlene Sicilia , Satryo Fatimatuz Zahra Oviary , Rachman Melinda Putri Amelia , Meiliani Fauzul , Hapsari Pharmasinta Putri , Zulkarnain Bambang Subakti , Rosyid Alfian Nur , Budiarti Tamara Nur , Wardhani Brigitta Dhyah Kunthi 
Published: July 2022

Long-term COVID-19 could occur in COVID-19 patients, affecting the patient's quality of life, and becoming a problem for public health. However, information is rarely on factors associated with the occurrence of long COVID-19 cases. This study analyzed factors associated with long-term COVID-19. The study was an observational cross-sectional, conducted in August 2021. The data were collected through a Google form questionnaire distributed to COVID-19 survivors in Indonesian. They must be aged more than 17 years to meet the inclusion criteria, while those with incomplete data were excluded. The data were processed by using SPSS 21 with an ordinal regression test in which an alpha level was 5%. As many as 101 from 16 men (15.8%) and 85 women (84.2%) were obtained. Comorbid status (p-value = 0.001) and duration of treatment (p-value = 0.034 and 0.015) had a significant association with the occurrence of long-term COVID-19. Meanwhile, age, gender, occupation, type of care, and vaccination status were not likely associated with long-term COVID-19. COVID-19 patients with comorbidity and a long duration of treatment are more likely to experience long-term COVID-19.
Keywords: COVID-19, long-term COVID-19, factor, public health
Design, Optimization and Evaluation of Etoricoxib Castor Oil Emulgel for acute gout therapy
Authors: Sharma Khushboo , Rai Janki Prasad , Somkuvar Sushma , Singhai Akhlesh Kumar 
Published: July 2022

Etoricoxibis is a non-steroidal anti-inflammatory drug which showed anti-inflammatory, analgestic and antipyretic activities. Etoricxib is indicates in the management of Osteoarthritis, Rheumatoid and Acute gout. The major drawback of topical dosage form is dissolution and diffusion of drug in the delivery of hydrophobic drugs, and permeation through stratum corneum is for hydrophilic drugs, thus, to be referred as emulgels. In emulgel formulations, oil-in-water and water-in-oil emulsions are commonly utilised as vehicles to deliver different hydrophilic and hydrophobic medications to the skin. They're also good in dissolving drugs and penetrating skin. Oil-in-water emulsions are mostly used as medication bases that may be washed away. The proposed research project intends to create an emulgel containing the analgesic drug Etoricoxib. The created emulgel containing etoricoxib medicines has a topical route that is more permeable, regulated, and localised. The analytical procedure of etoricoxib medicine was assessed using described UV spectrophotometric techniques in pH Phosphate buffer 6.8 and exhibited good linearity of data, as demonstrated by correlation coefficients greater than 0.998. For organoleptic characteristics, flow qualities, and partitioning, preformulation experiments were employed. All result of preformulation study was satisfactory and drug was examined visually for their feeling after application on skin, color intensity, pH determination, consistency and extrudability determination. The result concluded that ETEG4 was best formulation. This formulation ETEG4 was prepared emulgel Carbopol 940 (2g), PVP, castor oil base. The drug release profile and release kinetics are two important characteristics of the dosage forms, which play an important role for describing dissolution profile of dosage form. The dissolution data was obtained and ETEG4 showed supercase II transport mechanism.
Keywords: Etorcoxib, Castor Oil, Emulgel, Osteoarthritis, Rheumatoid, Acute gout
Design, Synthesis, Pharmacological Evaluation and DFT Investigation of New Bioactive Unsymmetrical Bi-Functional Ligand
Authors: Najar Adel M. , Omar Ruwida M.K. , Bobtaina Eman , Jabber Salem , Mohamed Najwa , Aeyad Tahani , Tawati Salha M. , Khalifa Aliaa M. M. 
Published: July 2022

Compounds with more than one bioactive motif become of great interest. In this regard, a new tridentate 1,2-unsymmetrical ligand consists of flexible and rigid bioactive arms spaced by benzene ring in an ortho position designed to form a bifunctional molecule. The 2-((3-(pyridin-2-yl)-1H-pyrazol-1-yl)methyl)benzonitrile (PPMB) synthesized under phase transfer reaction and characterized using 1H-NMR and mass spectroscopy and studied as potent kinase inhibitors. Theoretically, the molecule structure was investigated at the B3LYP/6-311++G(d,p) level of theory in the gas phase and revealed that all bond lengths and bond angles within the accepted limit. The frontier molecular orbitals (FMO) energies (HOMO and LUMO), energy gap, dipole moment, chemical softness and chemical hardness were calculated. Pharmacologically, the ligand activity was investigated in silico using SWISS ADME. Furthermore, the compound was docked into the transforming growth factor (TGF) beta type I receptor kinase active site to evaluate the ability of ligand as a kinase inhibitor.
Keywords: DFT, pyrazolyl-pyridine, physiochemical, properties molecular docking, bioactive molecules, unsymmetrical ligands
Multi-Functional Therapeutic Active Extract of Marine Asterias rubens against Tooth Decay Pathogen
Authors: Vijayalakshmi S. , Mohankumar A. 
Published: July 2022

Today, childhood caries is main health related disease it affects many schooling children in many countries especially developed by lactic acid bacteria. So in this present the isolating the 50 lactic acid bacteria from different decay affected children’s in Fen Dental Clinic, Tirupur Dt. The emerging bacteria LAB confirmed by phenotype and genotype characterization. After, the pathogen screened for the production of biofilm for to check the resistant mechanism of the Lactobacillus acidophilus. In this study the MTLA1-50 isolates produced strong biofilm were confirmed for the Lactobacillus acidophilus carrying resistant capability. In particularly, the maximum strong biofilm producing strains MTLA32 and MTLA50 followed by other isolates. Due to pre-dominant resistant activity immediately need innovative drug to eliminate biofilm. Currently star fish extract play a vital role in eliminating the bacterial biofilm for this motive in this study chosen the star fish extract in the concentration of 50, 100, 150µl was performed and executed by well diffusion techniques. The results showed the strain No. MTLA32 and MTLA 50 got the maximum zone of inhibition at 150µl (52mm and 38mm) of extract. Hence this research paper proved the star fish extract has a powerful anti-therapeutic medicine mechanism to treat the dental pathogen.
Keywords: Star Fish Extract, Dental Caries, Biofilm Production.
Anti-Inflammatory Properties of Quercetin: A Review
Authors: Nweze Chibuzo Carole , Tseaa Wandoo , Ekpe Ini Patrick 
Published: July 2022

Quercetin, one of the most taken flavonoid with diet, belongs to the family of flavonols. Quercetin occurs as a glycoside or as an aglycone and is gotten from various dietary sources such as apples, berries, onions, kale. Quercetin is being reviewed based on its bioavailability, metabolism and anti-inflammatory properties. Inflammation is the body's immune response to an irritant; this could be a pathogen or foreign object. An inflammatory response is either acute or chronic depending on the duration of inflammation and prolonged inflammatory response can lead to various diseases that are harmful to the body. Studies have shown that quercetin exerts good anti-inflammatory, antioxidant and anti-allergic activity by acting on leukocytes, targeting signaling kinases as well as membrane proteins crucial for an inflammatory response and acts as a scavenger of free radicals. Quercetin also down regulates the expression of pro-inflammatory factor while up regulating the expression of anti-inflammatory factor and this aids in maintaining homeostasis. Although poorly bioavailable due to its rapid metabolism, quercetin is an effective modulator of inflammation.
Keywords: Quercetin, inflammation, antioxidants, flavonols, free-radicals
Review: Hydrotropy as Prominent Approach for Enhancement of Aqueous Solubility of Drugs
Authors: Kazi Maseera Rizwan , Gandhi Sanket , Desai Shubham V. , Barse Rohan , Jagtap Vijay 
Published: July 2022

Solubility is crucial element to achieve the desired drug absorption in the total pharmacological response. Low water solubility can considerably limit the medication efficacy, and to improve aqueous solubility, a variety of approaches are employed. The capacity which increases water solubility for particular drug can thus be a useful tool for enhancing efficiency and/or decreasing negative effects. This is true for parental administered, topically applied and orally consumed solutions. It is a difficult work for researchers and pharmaceutical scientist to use solubility features in bioavailability, pharmacological effect and solubility enhancement of diverse weakly soluble substance. Hydrotropy is one of the strategies for increasing solubility. The purpose of this paper is to examine the hydrotropy Solubilization technique and to highlight the mechanism and different prospective of this method.
Keywords: Hydrotropy, mechanism, formation of hydrotropes, Solubility
COVID-19: New Challenge in 21st Century
Authors: Tamboli Siddhesh Sunil , Surwade A.B. , Mahale K.J. , Darekar A.B. , Wagh L.K. , Ugale P.G. 
Published: July 2022

COVID-19 pandemic turned into the proven existence-threatening virus in-line with World Health Organization (WHO) has declared a public health emergency of International Concerned and our healthcare system found a challenge to save human civilization. This evaluation gives a brief idea of COVID-19 epidemiology, pathophysiology, treatment, and prevention of COVID-19. Exclusive drugs like Dexamethasone and Remdesivir were found effective to treat the virus was covered in this review article. Pathophysiology of virus in the body of diabetes and cancer patients, there mechanism of action and risk involved in that patients were studied. This review turned to conduct on data found in science direct, various information sources on the internet and different review articles were studied. The major objective is to provide a brief overview of this disease, study infectious virus effect on human beings proves to be an existence-threat to the world population and brief overview of COVID-19 was covered in this review article.
Keywords: SARS-CoV-2, MERS, Vaccine, Dexamethasone, Remdesivir.
In vivo assessment of acute and subchronic toxicity of hydroethanolic extract of Ximenia americana L. (Olacaceae) stem bark
Authors: TOGBOSSI Lucie Akouélévi , Lawson-Evi Povi , Atchou Nestor K. , Motto Enam A. , Diallo A. , Eklu-Gadegbeku Kwashie , Aklikokou Kodjo 
Published: July 2022

Many studies have confirmed the traditional use of Ximenia americana (Olacaceae). Its different parts, leaf, fruit, roots, stem bark and root bark have showed pharmacological potentials. X. americana is a plant which possessed antibacterial, antidiabetic, antiviral and anticancer properties. The present study was undertaken to evaluate the oral acute and subchronic toxicity of hydroethanolic extract of X. americana stem bark on Sprague Dawley rats. In acute test, female rats were administrated once 5000 mg/kg and observed during 14 days for determination of toxicity signs. For the subchronic toxicity the extract (500 mg/kg and 1000 mg/kg) was administrated daily to both sexes of rats during 28 days. Control rats were administrated distilled water. Animals were observed, food and water consumption, mortality were monitoring during experiment period. Body weight, organs relative weight, hematological and biochemical parameters and histopathological changes were conducted at the end of treatment. Acute toxicity test revealed no adverse effects and no mortality. Extract administration during 28 days does not cause any behavioral change, change in body and organs relative weight and mortality. No significant variation was observed in hematological, biochemical parameters between treatment and control groups. No remarkable structural change was found in organs. However, triglycerides show significant variation in both sexes but this variation was not dose dependent. Results suggested that the LD50 of hydroethanolic extract of X. americana stem bark is higher than 5000 mg/kg and extract administration at 1000 mg/kg during 28 days does not cause toxicity in Sprague Dawley rats.
Keywords: Ximenia americana; stem bark; acute toxicity; subacute toxicity; hematological parameters; biochemical analysis.
Female Obesity: A Probable Cause of Infertility
Authors: Nair Nayana B , Skaria Minnu , Sambath Kumar R. 
Published: July 2022

Obesity, a serious health problem, is a widespread affliction among women of reproductive age. Obesity and overweight refer to an abnormal and excessive fat deposition that has a negative impact on the body's health. Obesity causes a slew of issues, including social, psychological, demographic, and health issues. It has been associated to elevated health risks like diabetes, hypertension, coronary heart disease, and osteoarthritis, as well as numerous cancers like endometrial, breast, and colon cancers. Hyperandrogenemia is caused by insulin resistance and hyperinsulinemia in obese women. The levels of sex hormone-binding globulin (SHBG) are lower, but leptin levels are higher. Impaired ovulatory function and, as a result, reproductive health could be explained by these changes. Obese women have a reduced probability of giving birth to a healthy infant due to lower implantation and pregnancy rates, greater miscarriage rates, and increased maternal and fetal problems throughout pregnancy. In these people, losing weight has a positive impact on their reproductive outcomes.
Keywords: Obesity, Hyperandrogenemia, Sex hormone-binding globulin (SHBG).