bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of anxiety disorders and its co-occurrence with substance use disorder: a clinical study
Authors: Soraya Shiva , Mahdavi Mehri , Saeidi Mahdieh , Seddigh Ruohollah , Nooraeen Sara , Sadri Mehrdad , Najafabadi Amir Jahanian 
Published: April 2022

Abstract
Background
Epidemiological studies are necessary to develop diagnostic standards for mental disorders. Therefore, this study investigated the prevalence of anxiety disorders, and its correlation with different substances used by patients diagnosed with substance use disorder referred to the Iran Psychiatric Hospital located in Tehran, Iran. Two hundred ninety-two male patients aged 18–65 (Meanage = 36.11, SD = 10.55) were recruited according to the available participant pool. Structured Clinical Interview for DSM-V Axis I Disorders was used to investigate their simultaneous anxiety disorders, and then the correlations with the different substances used during the past year before our study were considered. Based on clinical evaluation and structured psychiatric interviews, we investigated panic disorder, agoraphobia, social anxiety disorder, and generalized anxiety disorder.

Results
Results revealed that generalized anxiety disorder was the most common type of anxiety disorder among subjects of the current study. Further investigations revealed that panic disorder was significantly correlated with the abuse of cannabis (r = 0.116, p value = 0.047), tramadol (r = 0.205, p value < 0.001), and LSD (r = 0.197, p value = 0.001). Moreover, social anxiety disorder was correlated with cannabis (r = 0.124, p value = 0.035), opium (r = 0.186, p value = 0.001), methadone (r = 0.152, p value = 0.010), tramadol (r = 0.258, p value < 0.001), alcohol (r = 0.133, p value = 0.023), LSD (r = 0.123, p value = 0.036), and benzodiazepines (r = 0.168, p value = 0.004). The results indicated that none of the substances was correlated with generalized anxiety disorder as well as agoraphobia. However, agoraphobia had correlations with the intravenous injection as the main route of administration (r = 0.174, p value = 0.004).

Conclusions
Here this study supports the notion that co-occurrence of psychiatric disorders is relatively common and must be taken into consideration when assessing a patient and following up the treatment.
Cephalic arch stenosis in autologous hemodialysis fistula; to stent or not to stent? Long-term follow up
Authors: Abdelsalam Hassan 
Published: April 2022

Abstract
Background
A retrospective study of 44 patients with autologous arteriovenous fistula (AVF) presenting with cephalic arch stenosis was carried out. The aim is to assess the effectiveness of angioplasty and stenting in cephalic arch stenosis in autologous AVF in hemodialysis patients and also to assess the outcome of metal stents at this distinctive anatomical site. All patients were subjected to Doppler examination, where the stenotic lesion and the AVF flow volume were assessed prior to intervention. The follow-up period reached up to 57 months in some patients. All patients were under surveillance and were assessed for patency and flow volume. The primary and secondary stenosis-free rates were calculated. Re-intervention during the follow-up period was recorded.

Results
The technical success rate was 100%. Twenty-six patients had balloon angioplasty. Eighteen patients had primary and/or secondary stents inserted. The primary patency rate at 6 and 12 months for the balloon angioplasty group was 80% and 60% and for the stent group was 86% and 71%, respectively. The mean primary patency rate in balloon angioplasty patients was 12.9 months, while in the primary stented patients was 19.9 months. Twenty-six patients had secondary intervention. The average secondary patency rate for patients with balloon angioplasty was 25.5 months, while it was 33.6 months in the stented patients.

Conclusion
Cephalic arch angioplasty and stenting is an effective intervention increasing the longevity of the AVF that is crucial for hemodialysis patients. The use of metal stents whether bare metal stents or covered stents is safe and adds significant increase in patency rates.
Abnormal origin of the vertebral arteries with Bicarotid trunk: a case report
Authors: Topaloğlu Ömer Faruk , Cebeci Hakan , Kılınçer Abidin , Özer Halil 
Published: April 2022

Abstract
Background
Aortic arch and vertebral artery anomalies are vascular variations that occur as a result of embryological developmental defects. Bicarotid trunk anomaly is a rare aortic arch anomaly and refers to a common single trunk origin of common carotid arteries. VA origin anomalies are mostly unilateral and the most common is the LVA originating from the aortic arch. Abnormal origin of the RVA from the RCCA is a rare vascular anomaly. In this case, we presented ARSA and bicarotid trunk anomaly with abnormal origin of the vertebral arteries.

Case presentation
A 64-year-old male was admitted to our center with complaints of chronic headache and dizziness. In addition to ARSA and bicarotid trunk anomaly, RVA originating from RCCA and LVA originating from aortic arch were observed in CT angiography. The origin of LVA was between the bicarotid trunk and LSCA. Both VA were entering the transverse foramen at the level of the C6 vertebra. These anomalies were also revealed in detail by MR angiography of head/neck.

Conclusion
Aortic arch anomalies are a group with different subtypes. Awareness of VA origin anomalies is important for planning surgical and endovascular interventional procedures.
Phase Ib Study of Navicixizumab Plus Paclitaxel in Patients With Platinum-Resistant Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Authors: Fu Siqing , Corr Bradley R. , Culm-Merdek Kerry , Mockbee Colleen , Youssoufian Hagop , Stagg Robert , Naumann R. Wendel , Wenham Robert M. , Rosengarten Rafael D. , Benjamin Laura , Hamilton Erika Paige , Moore Kathleen N. 
Published: April 2022

PURPOSE This phase Ib study evaluated the safety and efficacy of paclitaxel plus navicixizumab, a bispecific antiangiogenic antibody to vascular endothelial growth factor and delta-like ligand 4, against platinum-resistant ovarian cancer. PATIENTS AND METHODS This open-label, nonrandomized, dose-escalation and -expansion study included 44 patients with previously treated, recurrent, platinum-resistant grade 2/3 ovarian cancer. Treatment was intravenous navicixizumab (3 mg/kg or 4 mg/kg once every 2 weeks) plus paclitaxel (80 mg/m2 intravenously on days 0, 7, and 14 of 28-day cycles). The primary and secondary objectives were to evaluate the safety and efficacy of navicixizumab plus paclitaxel. An RNA-based diagnostic panel was retrospectively used to test the hypothesis that tumors with high angiogenesis or immune-suppressed tumor microenvironment (TME) subtypes (biomarker-positive) are more likely to respond to navicixizumab than those with immune-active/-desert TME subtypes (biomarker-negative). RNA expression was analyzed in available pretreatment tumor tissue to classify 33 patients' TME subtypes, and TME panel findings were correlated with tumor response. RESULTS The dose-escalation cohorts enrolled patients at navicixizumab doses of 3 mg/kg once every 2 weeks (n = 3) and 4 mg/kg once every 2 weeks (n = 2); 3 mg/kg was selected for expansion (n = 39). No dose-limiting toxicities occurred. The most common grade 3/4 treatment-related adverse events were hypertension (40.9%), neutropenia (6.8%), and thrombocytopenia (4.5%). Pulmonary hypertension occurred in 18.2% (grade 1-2). The overall objective response rate was 43.2% (95% CI, 28.3 to 59.0): 33.3% (95% CI, 17.3 to 52.8) in patients previously treated with bevacizumab, 64.3% (95% CI, 35.1 to 87.2) in bevacizumab-naive patients, and 62% (95% CI, 31.6 to 86.1) in biomarker-positive patients. The median duration of response was 6 months (95% CI, 5.4 months to not estimable). CONCLUSION Navicixizumab plus paclitaxel demonstrated promising clinical activity in bevacizumab-treated and -naive patients with platinum-resistant ovarian cancer, with manageable toxicity.
Assessing the anticancer effects of metformin
Authors: Yunus Mohammed , Zaher Amr , Hussain Sajid , Alawami Karam Ali , Alfaraj Dhiyaa Jaber , Alqatari Ahmed Mohammed , Alsalim Morteda Jasim , Almissri Murtaja Zaki , Junaid Mohammed Abdul Lateef 
Published: April 2022

Background: Metformin is an antihyperglycemic biguanide that is used as the first-line treatment for type 2 diabetes mellitus (T2DM). Metformin use helps control T2DM which is one of the many risk factors for cancer and is proposed to have multiple antagonistic actions against cancer cells. Metformin induces adenosine monophosphate-activated protein kinase (AMPK)-driven cascades, involving two pathways, a direct and an indirect one. This leads to a decrease in the mechanistic activity of mammalian target of rapamycin (mTOR), folate level, c-MYC (a family of regulator genes and proto-oncogenes), NF-κB (nuclear factor kappa of B cell), and also increases tumor suppressor P53 phosphorylation. These cascades will also decrease cyclin D1, reactive oxygen species (ROS), and increase mTOR complex1 (mTORC1) concentrations, apoptosis, and autophagy. Metformin also exerts anti-inflammatory effects through reducing interleukins 6 (IL6) and 8 (IL8), inhibition of protein translation via LKB1 (liver kinase B1), increasing expression of GPD1 (glycerol-3-phosphate dehydrogenase 1) which suppresses cancer by inhibiting mitochondria, inducing cell apoptosis, and inhibiting leptin while increasing adiponectin production. We would like to assess the anticancer effect of metformin on various types of malignancies. Methods: The 266 cancer patients diagnosed in 2018–2019 in King Fahd Hospital of the University (KFHU) were divided into non-diabetic and diabetic cancer patients (with or without metformin). The data includes age, gender, body mass index (BMI), type of cancer with grades and stages, T2DM, with or without metformin, complications, and fate etc. of each case. Results: Out of 300, 266 were selected for the analysis. The results showed the statistical significance (p value 0.022) of metformin use on the cancer grade at diagnosis that favorably influences the morbidity/mortality. Conclusions: Metformin might have an anti-cancer effect on the grade of cancer at the time of diagnosis regardless of its dosage, and this might improve the prognosis of malignancy.
The Ostomy Skin Tool 2.0: a new instrument for assessing peristomal skin changes
Authors: Martins Lina , Down Gillian , Andersen Birgitte Dissing , Nielsen Lene Feldskov , Hansen Anne Steen , Herschend Nana Overgaard , Størling Zenia 
Published: April 2022

Background: Peristomal skin complications (PSCs) are frequently reported postoperative complications. PSCs can present visibly or as symptoms such as pain, itching or burning sensations. Aim: To develop a new tool that can capture a range of sensation symptoms together with visible complications and an objective assessment of discolouration in the peristomal area. Method: Consensus from qualitative interviews with health professionals and people with an ostomy, and input from expert panels, formed the basis of a patient-reported outcome (PRO) questionnaire. A decision tree model was used to define a combined score including PRO and objectively assessed discolouration area. Findings: Six elements were included in the PRO questionnaire and four health states representing different severity levels of the peristomal skin were defined. Conclusion: The Ostomy Skin Tool 2.0 is a sensitive tool that can be used to follow changes in the peristomal skin on a regular basis and thereby help prevent severe PSCs.
Impact of inflammatory bowel disease on partners: a qualitative study
Authors: Thapwong Parichat , Norton Christine , Terry Helen , Czuber-Dochan Wladyslawa 
Published: April 2022

Background:Extensive studies have documented the impacts of inflammatory bowel disease (IBD) on patient quality of life, but this study addresses the gap concerning IBD outcomes for the family members of adult IBD patients.Aims:To explore the lived experience of IBD patients and their family members regarding impacts of IBD on family members and their coping strategies.Methods:Semi-structured, in-depth, online interviews were held via Skype, Microsoft Teams and Zoom from February to June 2020, with 12 purposively selected participants, comprising six IBD patients with their six partners. Interviews were audio-recorded and transcribed verbatim, for inductive thematic data analysis.Results:Four main themes emerged during the analysis under the central theme ‘our relationship with IBD, for better or worse’. The theme ‘our relationship’ revealed the impact of IBD on intimate relationships, family planning, role change as partner and carer, and the importance of honest communication. IBD also affected wider relationships with family, children and social life, but teamwork could mediate negative impacts on relationships. Living in constant fear and guilt impacted on emotional wellbeing. Humour and knowledge of IBD reduced negative impacts. IBD had impacts on everyday life (diet, finances and travel) for both patients and partners. Planning for uncertain situations was helpful to reduce restrictions.Conclusions:There are wide-ranging implications for healthcare providers (gastroenterologists, GPs and IBD nurses), social care professionals (psychologists and social workers), family therapists and researchers who could incorporate a bio-psycho-social approach to working with patients with IBD to improve services for individuals who have IBD and their partners and families.
The Flattening and Stiffening Effect of Centrifugal Stress on Circular Saw Blades in Different States
Authors: Li Bo , An Yuan 
Published: April 2022

Abstract
Circular saw blades have many states, before and during the sawing process, depending on the different residual stresses and flatness of the circular saw blades. Based on the different states of circular saw blades, the effect of rotating centrifugal stress on the dynamic stability of circular saw blades is different, mainly reflected in flattening and stiffening effects. In this article, three representative states of circular saw blades were chosen and studied. The finite element method was chosen to simulate the deformation behavior of circular saw blades in the three states. The flattening and stiffening effects of centrifugal stress on circular saw blades in the three states were systematically studied. The axial stiffness of the outer edge of circular saw blades is increased with rotating speed. The rotating speed has a flattening effect on the circular saw blade, as a result of a centrifugal stress field. When the circular saw blade is in a different state, there are some differences in the flattening and stiffening effect of centrifugal stress.
Aimé Césaire e seu discurso poético sobre as Antilhas/ Aimé Césaire and his poetic speech on the Antilles/ Aimé Césaire et son discours poétique sur les Antilles
Authors: Azevedo Érika Pinto de 
Published: April 2022

Résumé : Entre 1941 et 1945, Aimé Césaire (1913-2008), écrivain martiniquais alors professeur de lycée à Fort-de-France, publie des poèmes dans des revues diverses, et notamment dans Tropiques, revue culturelle lancée en Martinique par Aimé Césaire lui-même, sa femme Suzanne, René Ménil, Aristide Maugé et d’autres intellectuels de l’île. En 1946, quelques-uns de ces poèmes sont retravaillés pour paraître pour la première fois en volume sous le titre Les Armes miraculeuses. Cet article se penche sur l’écriture des Armes miraculeuses, recueil de poèmes qui, avec Tropiques, participe à cette entreprise commune d’élaboration d’un discours sur la culture antillaise et ses héritages africains. Il s’inscrit dans le cadre d’une recherche menée à l’Université Fédérale de l’Amapá et intitulée “Les rapports entre le réel et l’imaginaire dans les littératures modernes de langue française : Aimé Césaire et Léon-Gontran Damas”. Pour ce faire, elle présente d’abord quelques données portant sur le parcours de l’écrivain ainsi que sur la genèse des Armes miraculeuses pour examiner ensuite “Avis de tirs”, poème liminaire. Discours poétique sur les Antilles, on peut percevoir dans ce poème le rapport entre la conception poétique particulière de l’écrivain et les luttes générales qu’il a engagées dans le cadre de la Martinique sous le joug colonial de la métropole lors de la Seconde Guerre mondiale, à savoir la décolonisation de territoires et de la pensée.
Infância e devir-selvagem: uma problematização a partir de Gilles Deleuze
Authors: Correia Jardim Alex Fabiano , Soares Érika Mariana Abreu 
Published: April 2022

Este texto procura pensar a infância e o seu devir-selvagem problematizando o corpo infantil e as práticas pedagógicas da instituição escolar. Práticas que hierarquizam as relações, reproduzem modelos de ensino, imprimem rotina, demandam repetição, representação, imitação, exigem organização e ordenamento ao corpo infantil. Por outro lado, o corpo infantil nos mostra o movimento da infância e o seu devir-selvagem. Movimento que possibilita os corpos escaparem do modelo de sociedade que assujeita o corpo a viver uma única realidade de mundo. Um corpo em devir-selvagem cria outros mundos possíveis operando fissuras nas hegemonias e construindo redes de afeto que invencionam outros modos de existir. Para orientar essa problematização escolhemos os estudos do filósofo francês Gilles Deleuze.
Ensino do Português na França e cidadania: a questão descolonial
Authors: Champagnat Pauline 
Published: April 2022

RESUMO: Ao abordar a cultura dos países africanos de língua portuguesa, o professor de língua portuguesa se encontra no desafio de tratar de assuntos como a escravidão, o comércio negreiro, a colonialidade mas também do processo da pós-colonialidade. Isso permite também traçar paralelos com a situação francesa, e refletir sobre o próprio processo de descolonização nas colônias francesas, e a relação que este país ainda mantém com elas. Desta maneira, pretendemos demostrar que o ensino do português pode implicar uma responsabilidade de sensibilização para temas atuais de extrema importância ligados à pós-colonialidade.
PALAVRAS-CHAVE: PLE, França, África lusófona, descolonial.
ABSTRACT: When he addresses the subject of Portuguese-speaking African countries, the Portuguese teacher is confronted with the challenge of discussing topics such as slavery, the triangular trade, colonialism but also the post-colonialism process. That is why it makes it possible to draw a parallel with the French situation and reflect about the decolonization process in French former colonies, and the relation that this country still maintains with them. This way, we intend to prove that the Portuguese learning process might imply a responsibility of awareness around major contemporary topics linked to post-coloniality.
KEYWORDS: PLE, France, Portuguese-speaking Africa, decolonial.
O rei está morto, viva o rei: uma leitura do conto “Refluxo”, de José Saramago
Authors: Costa F Edil , Vital Oliveira Santos Alisson 
Published: April 2022

Nesse artigo, mapeamos algumas obras literárias que representam um gesto de aprendizado da morte pela literatura, como forma de discutir o impacto da pandemia e a estratégia da representação desse imaginário da morte na obra de José Saramago com uma leitura do conto Refluxo.
Palavras-Chave: morte; literatura; pandemia; Saramago
Introduction to the ONDM 2021 special issue
Authors: Furdek Marija , Monti Paolo , Mas Machuca Carmen , Turkiewicz Jarosław , Larrabeiti David 
Published: April 2022

This JOCN special issue contains extended versions of selected papers presented at the 25th International Conference on Optical Network Design and Modeling (ONDM 2021), which took place virtually from 28 June through 1 July 2021. The topics covered by the papers represent clear trends in current optical networking research, including capacity upgrade through transmission parameter optimization in multiband systems, spectral efficiency improvement through probabilistic constellation shaping in Flex Grid/multicore fiber networks, novel point-to-multipoint optical architectures based on digital subcarrier multiplexing that enable a rethink of multilayer network design, and trustworthy inter-operator sharing of passive optical network capacity based on a smart contract.
A national survey integrating clinical, laboratory, and WASH data to determine the typology of trachoma in Nauru
Authors: Lynch Kathleen D. , Apadinuwe Sue Chen , Lambert Stephen B. , Hillgrove Tessa , Starr Mitchell , Catlett Beth , Ware Robert S. , Cama Anasaini , Webster Sara , Harding-Esch Emma M. , Bakhtiari Ana , Butcher Robert , Cunningham Philip , Martin Diana , Gwyn Sarah , Solomon Anthony W. , Garabwan Chandalene , Kaldor John M. , Vaz Nery Susana 
Published: April 2022

Background
The epidemiology of trachoma in several Pacific Islands differs from other endemic settings, in that there is a high prevalence of clinical signs of trachoma, particularly trachomatous inflammation—follicular (TF), but few cases of trichiasis and limited evidence of ocular chlamydial infection. This so-called “Pacific enigma” has led to uncertainty regarding the appropriate public health response. In 2019 alongside Nauru’s national trachoma population survey, we performed bacteriological and serological assessments of children to better understand the typology of trachoma and to determine whether there is a need for trachoma interventions.

Methods
We used two-stage cluster sampling, examining residents aged ≥1 year and collecting household-level water, sanitation, and hygiene (WASH) variables. Children aged 1–9 years provided conjunctival swabs and finger-prick dried blood spots to investigate the presence of Chlamydia trachomatis nucleic acid and anti-Pgp3 antibodies, respectively.

Principal Findings
In 818 participants aged 1–9 years, the age-adjusted TF prevalence was 21.8% (95% CI 15.2–26.2%); ocular C. trachomatis prevalence was 34.5% (95% CI 30.6–38.9), and anti-Pgp3 antibody prevalence was 32.1% (95% CI 28.4%–36.3%). The age- and gender-adjusted prevalence of trichiasis in ≥15-year-olds was 0.3% (95% CI 0.00–0.85), but no individual with trichiasis had trachomatous scarring (TS). Multivariable analysis showed an association between age and both TF (OR per year of age 1.3 [95% CI 1.2–1.4]) and anti-Pgp3 positivity (OR 1.2 [95% CI 1.2–1.3]). There were high rates of access to water and sanitation and no WASH variable was associated with the presence of TF.

Conclusions
TF, nucleic acid, and age-specific antibody prevalence collectively indicate that high levels of C. trachomatis transmission among children present a high risk of ocular damage due to trachoma. The absence of trichiasis with trachomatous scarring suggest a relatively recent increase in transmission intensity.