bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel pH‐responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan‐based nanocarrier: Emphasis on the concurrent improvement of loading, sustained release, and apoptosis induction
Authors: Haseli Shabnam , Pourmadadi Mehrab , Samadi Amirmasoud , Yazdian Fatemeh , Abdouss Majid , Rashedi Hamid , Navaei‐Nigjeh Mona 
Published: June 2022

AbstractCurcumin application as an anti‐cancer drug is faced with several impediments. This study has developed a platform that facilitates the sustained release of curcumin, improves loading efficiency, and anti‐cancer activity. Montmorillonite (MMT) nanoparticles were added to chitosan (CS)‐agarose (Aga) hydrogel and then loaded with curcumin (Cur) to prepare a curcumin‐loaded nanocomposite hydrogel. The loading capacity increased from 63% to 76% by adding MMT nanoparticles to a chitosan‐agarose hydrogel. Loading the fabricated nanocomposite in the nanoniosomal emulsion resulted in sustained release of curcumin under acidic conditions. Release kinetics analysis showed diffusion and erosion are the dominant release mechanisms, indicating non‐fickian (or anomalous) transport based on the Korsmeyer‐Peppas model. FTIR spectra confirmed that all nanocomposite components were present in the fabricated nanocomposite. Besides, XRD results corroborated the amorphous structure of the prepared nanocomposite. Zeta potential results corroborated the stability of the fabricated nanocarrier. Cytotoxicity of the prepared CS‐Aga‐MMT‐Cur on MCF‐7 cells was comparable with that of curcumin‐treated cells (p < 0.001). Moreover, the percentage of apoptotic cells increased due to the enhanced release profile resulting from the addition of MMT to the hydrogel and the incorporation of the fabricated nanocomposite into the nanoniosomal emulsion. To recapitulate, the current delivery platform improved loading, sustained release, and curcumin anti‐cancer effect. Hence, this platform could be a potential candidate to mitigate cancer therapy restrictions with curcumin.
Annonaceous Acetogenin Mimic AA005 Inhibits the Growth of TNBC MDA‐MB‐468 Cells by Altering Cell Energy Metabolism
Authors: Yu Bao‐Bao , Yuan Hao , Chen Yun‐Cong , Zhou Dan‐Xia , Gan Zhen‐Ji , Wang Jie , Li Jian‐Xin , Yao Zhu‐Jun 
Published: June 2022

AbstractTriple‐negative breast cancer (TNBC) is a serious health issue for women worldwide and there is still no suitable treatment option. AA005, a structurally simplified mimic of natural Annonaceous acetogenins, presents outstanding properties with impressive cytotoxicity and cell‐type selective actions. The present study was aimed at evaluating the potential of AA005 as a therapeutic agent for TNBC. AA005 potently inhibited the growth of TNBC cells at 50 nM level. Inspired by the finding of the phosphatase and tensin homologue (PTEN) tumor suppressor, the effect of AA005 on aerobic glycolysis was investigated in TNBC MDA‐MB‐468 cells. A short‐term AA005 exposure markedly suppressed mitochondrial function in MDA‐MB‐468 cells, thus activating the aerobic glycolysis to lessen the risk of decreased ATP generation in mitochondria. Prolonging the incubation time of AA005 clearly weakened the aerobic glycolysis in the cells. This was in part attributed to the PI3K‐AKT pathway inactivation and subsequent declined glucose uptake. As a consequence, the energy supply was completely cut from the two major energy‐producing pathways. Further experiments showed that AA005 resulted in irreversible damage on cell activity including cell cycle and growth, inducing mitochondrial oxidative stress and ultimately leading to cell death. In addition, the in vivo therapeutic efficacy of AA005 was proved on 4T1 xenograft tumor mice model. Our data demonstrate that AA005 exhibited a great potential for future clinical applications in TNBC therapy.
Large myoma receiving multiple collateral primary parasitic blood supply
Authors: Kathopoulis Nikolaos , Kypriotis Konstantinos , Diakosavvas Michail , Chatzipapas Ioannis , Zacharakis Dimitrios , Grigoriadis Themistoklis , Protopapas Athanasios 
Published: June 2022

AbstractWe describe a rare case of a pedunculated myoma receiving multiple de‐novo developed parasitic collateral blood supply from the adjacent organs. The main feeding vessels arise from the omentum and the bladder.
Clinicoradiologic diagnosis of a rare type of congenital adrenal hyperplasia: A case report from Nepal
Authors: Khadka Hensan , Bhandari Siddhartha , Dhakal Prakash , Sharma Suraj 
Published: June 2022

AbstractCongenital adrenal hyperplasia includes defects in the synthesis of steroid hormones in the adrenal cortex. The implications of this disorder manifest in other genitourinary organs, including ovaries and uterus. The diagnosis may be suspected based on the clinical and radiologic features.
An autopsy case of COVID‐19 with a sudden death: Clinico‐pathological comparison
Authors: Shishido‐Hara Yukiko , Furukawa Keizo , Nishio Manabu , Honda Kohei , Tando So , Yaoi Takeshi , Kawamoto Masataka , Maehara Yosuke , Nakaya Takaaki , Itoh Kyoko 
Published: June 2022

AbstractAutopsy was performed on a COVID‐19 patient, who suddenly died despite the extensive anti‐viral and anti‐inflammatory therapies. Although moderate subpleural fibrosis was seen, pathology of DAD, a well‐known cause for pulmonary failure, was minimum. Instead, severe hemorrhage was observed. Therapeutic effects were indicated; however, why severe hemorrhage occurred was unclear.
Foam in Absorption Columns with Structured Packings – Part 1: Characterization
Authors: Leuner Hannes , Gerke Sören Jakob , Illner Markus , Repke Jens-Uwe 
Published: June 2022

AbstractFoam in absorption and distillation processes is one of the main reasons for malfunctions in columns including higher pressure loss, lower throughput, and lower mass transfer rates leading to a reduction in separation efficiency. Detailed investigations on the foam formation and its behavior in structured packings are conducted using two different scales: a transparent rectangular measurement cell and a DN300 column. The influence of maldistributions in structured packing is discussed along with a first‐time identified foam‐related hysteresis effect. Ad‐ and disadvantages of fully wetted film flow and partially wetted rivulet flow on foam formation are discussed in detail. Overall, structured packings without a microstructure show a reduced foam formation compared to structured packings with a microstructure.
A high‐performance transition‐metal phosphide electrocatalyst for converting solar energy into hydrogen at 19.6% STH efficiency
Authors: Zhang Hua , Aierke Abuduwayiti , Zhou Yingtang , Ni Zitao , Feng Ligang , Chen Anran , Wågberg Thomas , Hu Guangzhi 
Published: June 2022

AbstractThe construction of high‐efficiency and low‐cost non‐noble metal bifunctional electrocatalysts for water electrolysis is crucial for commercial large‐scale application of hydrogen energy. Here, we report a novel strategy with erbium‐doped NiCoP nanowire arrays in situ grown on conductive nickel foam (Er‐NiCoP/NF). Significantly, the developed electrode shows exceptional bifunctional catalytic activity, which only requires overpotentials of 46 and 225 mV to afford a current density of 10 mA cm−2 for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER), respectively. Density functional theory calculations reveal that the appropriate Er incorporation into the NiCoP lattice can significantly modulate the electronic structure with the d‐band centers of Ni and Co atoms by shifting to lower energies with respect to the Fermi level, and optimize the Gibbs free energies of HER/OER intermediates, thereby accelerating water‐splitting kinetics. When assembled as a solar‐driven overall water‐splitting electrolyzer, the as‐prepared electrode shows a high and stable solar‐to‐hydrogen efficiency of 19.6%, indicating its potential for practical storage of intermittent energy.
Advances and applications of chiral resolution in pharmaceutical field
Authors: Teng Yan , Gu Chenglu , Chen Zhuhui , Jiang Hui , Xiong Yue , Liu Dong , Xiao Deli 
Published: June 2022

AbstractThe attention to chiral drugs has been raised to an unprecedented level as drug discovery and development strategies grow rapidly. However, separation of enantiomers is still a huge task, which leads to an increasing significance to equip a wider range of expertise in chiral separation science to meet the current and future challenges. In the last few decades, remarkable progress of chiral resolution has been achieved. This review summarizes and classifies chiral resolution methods in analytical scale and preparative scale systematically and comprehensively, including crystallization‐based method, inclusion complexation, chromatographic separation, capillary electrophoresis, kinetic resolution, liquid–liquid extraction, membrane‐based separation, and especially one bold new progress based on chiral‐induced spin selectivity theory. The advances and recent applications will be presented in detail, in which the contents may bring more thinking to wide‐ranging readers in various professional fields, from analytical chemistry, pharmaceutical chemistry, natural medicinal chemistry, to manufacturing of drug production.
Survey on recursive statistical process monitoring methods
Authors: Wang Youqing , Qin Yihao , Lou Zhijiang , Ma Xin 
Published: June 2022

AbstractRecursive statistical process monitoring (RSPM) methods have superior monitoring performance for industrial processes, especially those with time‐varying characteristics, and have recently been studied by many researchers. However, there is no survey paper yet that summarizes and analyzes the existing RSPM methods. In this survey, approximately 60 papers related to RSPM methods are reviewed and categorized from different aspects. Existing RSPM methods are categorized using the classification criteria proposed in this study based on the ways of recursively collecting data and the stages of recursive updating. Three core algorithms that are most commonly used in RSPM methods are uniformly summarized and analyzed specifically for studying recursive computation problems in RSPM methods. Furthermore, different types of multivariate statistical process monitoring (MSPM) methods that combine recursive computation are reviewed.
Anticancer Activity of Mannich Bases: A Review of Recent Literature
Authors: Roman Gheorghe 
Published: June 2022

AbstractThis report summarizes the latest published data on the antiproliferative action and cytotoxic activity of Mannich bases, a structurally heterogeneous category of chemical entities that includes compounds which are synthesized via the grafting of an aminomethyl function onto diverse substrates by means of the Mannich reaction. The present overview of the topic is an update to the information assembled in a previously published review that covered the literature up to 2014.
Enhanced Selectivity of the Propylene Epoxidation Reaction on a Cu Monolayer Surface via Eley‐Rideal Mechanism
Authors: Sangolkar Akanksha Ashok , Pawar Ravinder 
Published: June 2022

AbstractThe aerobic oxidation of propylene to selectively achieve propylene oxide (PO) is a challenging reaction in catalysis. Therefore, an active catalyst which shows enhanced PO selectivity is extremely desired. In the present investigation, an attempt has been made to explore the catalytic activity of a mono‐atomically thin two‐dimensional (2D) hexagonal (HX) Cu layer for selective propylene epoxidation using molecular O2 with the aid of density functional theory calculations. The results reveal that the conversion of propylene to PO via Eley‐Rideal mechanism is an exoergic and barrierless reaction on the O2 pre‐adsorbed Cu monolayer. The Pauli energy component plays a decisive role for barrierless reaction whereas the electrostatic and orbital contribution governs the energetic stability of PO. Car‐Parrinello molecular dynamics (CPMD) simulation reinforces the outcomes of climbing image nudged elastic band (CI‐NEB) calculation. Further, the formation of oxametallacycle OMC‐2 (0.47 eV) is kinetically favourable over OMC‐1 (0.87 eV) and AHS (0.50 eV) on O pre‐adsorbed 2D HX Cu. Interestingly, the energy barrier for the conversion of OMC‐2 to PO (0.70 eV) is considerably low in comparison with the acetone formation (0.90 eV). Therefore, it is worth to mention that the 2D HX Cu surface provides a promising platform for selective propylene epoxidation.
ZNF677 suppresses renal cell carcinoma progression through N6‐methyladenosine and transcriptional repression of CDKN3
Authors: Li Aolin , Cao Congcong , Gan Ying , Wang Xiaofei , Wu Tianyu , Zhang Quan , Liu Yuchen , Yao Lin , Zhang Qian 
Published: June 2022

AbstractBackgroundStudies on biological functions of N6‐methyladenosine (m6A) modification in mRNA have sprung up in recent years. Previous studies have reported m6A can determine mRNA fate and play a pivotal role in tumour development and progression. The zinc finger protein 677 (ZNF677) belongs to the zinc finger protein family and possesses transcription factor activity by binding sequence‐specific DNA.MethodsThe expression of ZNF677 and its clinicopathological impact were evaluated in renal cell carcinoma (RCC) patients. The m6A level of ZNF677 was determined by m6A methylated RNA immunoprecipitation‐sequencing (MeRIP‐seq) and MeRIP‐qPCR in RCC tissues and adjacent normal tissues. RNA immunoprecipitation‐qPCR (RIP‐qPCR) and luciferase assays were performed to identify the targeted effect of IGF2BP2 and YTHDF1 on ZNF677. RCC cells and subcutaneous models uncovered the role of ZNF677 methylated by CRISPR/dCas13b‐METTL3 in tumour growth. ZNF677‐binding sites in the CDKN3 promoter were investigated by chromatin immunoprecipitation (ChIP) and luciferase assays.ResultsZNF677 is frequently downregulated in RCC tissues and its low expression is associated with unfavourable prognosis and decreased m6A modification level. Further, we find the m6A‐modified coding sequence (CDS) of ZNF677 positively regulates its translation and mRNA stability via binding with YTHDF1 and IGF2BP2, respectively. Targeted specific methylation of ZNF677 m6A by CRISPR/dCas13b‐METLL3 system can significantly increase the m6A and expression level of ZNF677, and dramatically inhibit cell proliferation and induce cell apoptosis of RCC cells. In addition, ZNF677 exerted its tumour suppressor functions in RCC cells through transcriptional repression of CDKN3 via binding to its promoter. In vitro and clinical data confirm the negative roles of ZNF677/CDKN3 in tumour growth and progression of RCC.ConclusionZNF677 functions as a tumour suppressor and is frequently silenced via m6A modification in RCC, which may highlight m6A methylation‐based approach for RCC diagnosis and therapy.
Characteristic mode analysis of two port semi‐circular arc‐shaped multiple‐input‐multiple‐output antenna with high isolation for 5G sub‐6 GHz and wireless local area network applications
Authors: Addepalli Tathababu , Babu Kamili Jagadeesh , Beno A. , Potti Bala Murali Krishna , R Nageswara Rao , Sundari D. Thiripura , Devana V. N. Koteswara Rao 
Published: June 2022

SummaryThe work presents the design of a novel semi‐circular arc‐shaped two‐element multiple‐input‐multiple‐output (MIMO) antenna with improved isolation. The antenna is obtained by cutting and subtracting a circular disk from another circular disk, forming the shape of a semi‐circular arc. The antenna is replicated to form a two element MIMO antenna system on a FR4 substrate of size 36 × 26 mm2 with edge‐to‐edge separation of 12.4 mm. The developed MIMO antenna resonates in the frequency range 3.26 to 6.97 GHz giving a maximum element‐to‐element isolation around 26 dB in the operating bandwidth. Also, the antenna gives a maximum radiation efficiency of 98% with a peak gain of 5.3 dBi in the operating band. The proposed compact MMO antenna covers wide variety of wireless applications like 5G sub‐6 GHz and wireless local area network (WLAN) applications, which includes n77/n78/n79, WiFi‐5, V2X/DSRC, WiFi‐6, and INSAT‐C bands. Characteristic mode analysis (CMA) is performed in characterizing the performance of the antenna over the specified operating bands by studying and analyzing the parameters like modal significance (MS), characteristic angle (CA), modal current, and modal patterns. The obtained MIMO parameters like envelope correlation coefficient (ECC), diversity gain (DG), mean effective gain (MEG), and total active reflection coefficient (TARC) reveal that the proposed antenna is a suitable choice in MIMO environment.
Energy storage for photovoltaic power plants: Economic analysis for different ion‐lithium batteries
Authors: Morais Rafael C. , Lopes Mariana Padilha C. , Bellido Marlon Max H. , Pereira Amaro Olímpio , Castelo Branco David A. 
Published: June 2022

AbstractEnergy storage has been identified as a strategic solution to the operation management of the electric power system to guarantee the reliability, economic feasibility, and a low carbon footprint. In this sense, this article analyzes the economic feasibility of a storage system using different Li‐ion batteries applied to a real case of the photovoltaic power plant at Alto Rodrigues, Rio Grande do Norte, Brazil. The System Advisor Model software was used to simulate the systems which allowed showing the difference between the revenue obtained from energy sales and the total generation cost. According to the results, the viability of the energy storage system can be achieved in different ways. The first way would be to reduce current investment costs in storage systems. In the second way, the energy sale price is higher than the current sale price. The third and fourth ways are a combination of cost storage reduction and the increase of energy sale price in different annual proportions.
Forgetting approaches to improve forecasting
Authors: Hill Robert A. , Rodrigues Paulo M. M. 
Published: June 2022

AbstractThere is widespread evidence of parameter instability in the literature. One way to account for this feature is through the use of time‐varying parameter (TVP) models that discount older data in favor of more recent data. This practice is often known as forgetting and can be applied in several different ways. This paper introduces and examines the performance of different (flexible) forgetting methodologies in the context of the Kalman filter. We review and develop the theoretical background and investigate the performance of each methodology in simulations as well as in two empirical forecast exercises using dynamic model averaging (DMA). Specifically, out‐of‐sample DMA forecasts of Consumer Price Index (CPI) inflation and S&P500 returns obtained using different forgetting approaches are compared. Results show that basing the amount of forgetting on the forecast error does not perform as well as avoiding instability by placing bounds on the parameter covariance matrix.
Improvement of soil fertility in historical ridge and furrow cultivation
Authors: Langewitz Theresa , Wiedner Katja , Fritzsch Dagmar , Eckmeier Eileen 
Published: June 2022

AbstractRidge and furrow cultivation is the most widely used agricultural technique in medieval and postmedieval Europe, but the fertilization of soils during their use is not yet fully understood. Pedological analyses of this cultivation technique provided information, which led to the assumption that some of the investigated sites in Northern and Central Germany were manured with livestock excrements during cultivation. The objective of this study is to determine whether and how the soils have been fertilized and which materials were applied for this purpose. We investigated soils at five sites using phosphate and steroid analyses (stanols and bile acids), black carbon analyses, and a micromorphology study. The results showed that livestock waste was likely used as fertilizer at four of the five studied sites at low intensities, with pigs and herbivores being the probable sources of the excrement. But also the application of human feces to the soil might be possible at least at one site. Often used agricultural methods such as plaggen cultivation and an intentional charcoal input to enhance soil fertility could not be clearly verified for our study sites.
Perceived risk of contracting COVID‐19 among healthcare workers in Ghana: A cross‐sectional study
Authors: Aram Simon Appah , Saalidong Benjamin M. , Opoku Erica Odwira , Sam Hayford Isaac 
Published: June 2022

AbstractBackground and AimsThe COVID‐19 pandemic has stretched many healthcare systems, and it is having detrimental impacts on healthcare workers at the forefront, fighting to save lives. This study sought to assess the relationship between job factors and the perceived risk of contracting COVID‐19 at the workplace among healthcare workers and how the relationships are augmented when sociodemographic characteristics are taken into consideration in a limited resource setting (Ghana).MethodsA cross‐sectional survey of 455 respondents was conducted.ResultsOverall, 5.93% of the respondents perceived low risk of contracting COVID‐19 while 69.45% and 24.62% perceived medium and high risks of contracting COVID‐19 at the workplace, respectively. The odds of a high perceived risk versus the combined medium and low perceived risk of contracting COVID‐19 at the workplace was 0.461 times lower for healthcare workers who rated their workplace safety systems as good and 0.515 and 0.170 times lower for healthcare workers who indicated occasional and frequent work environment situational assessment (situational awareness), respectively. The odds of high perceived risk were 2.239 times higher for workers who are always emotionally fatigued and 1.829 times higher for healthcare workers who frequently contribute personally to workplace decision‐making. The perceived risk of contracting COVID‐19 at the workplace was also 1.780 times higher for healthcare workers with tertiary education.ConclusionIn terms of health and safety at work, this study recommends that there should be an improvement in implementing safety protocols at health facilities to increase the confidence of healthcare workers. Furthermore, social and psychological support and work environment situational assessment, which can reduce stress and anxiety levels among the healthcare workers, should be implemented if contributing factors such as working outside their area of expertise or job scope cannot be eliminated.