bluuebunny/crossref_metadata_2025_split huggingface dataset:
Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness
Authors: Makowski Carolina , Wang Hao , Srinivasan Anjali , Qi Anna , Qiu Yuqi , van der Meer Dennis , Frei Oleksandr , Zou Jingjing , Visscher Peter M. , Yang Jian , Chen Chi-Hua 
Published: May 2022

ABSTRACTHuman cortical expansion has occurred non-uniformly across the brain. We assessed the genetic architecture of cortical global expansion and regionalization by comparing two sets of genome-wide association studies of 24 cortical regions with and without adjustment for global measures (i.e. total surface area, mean cortical thickness) using a genetically-informed parcellation in 32,488 adults. We found 393 and 756 significant loci with and without adjusting for globals, respectively, among which 8% and 45% loci were associated with more than one region. Results from analyses without adjustment for globals recounted loci associated with global measures. Genetic factors that contribute to total surface area of the cortex particularly expand anterior/frontal regions, whereas those contributing to thicker cortex predominantly increase dorsal/frontal-parietal thickness. Interactome-based analyses revealed significant overlap of global and regional genetic modules, enriched for neurodevelopmental and immune system pathways. Consideration of global measures is important in understanding the genetic variants underlying cortical morphology.
Mitochondrial genome recovery by ATFS-1 is essential for development following starvation
Authors: Naresh Nandhitha Uma , Shpilka Tomer , Yang Qiyuan , Du Yunguang , Haynes Cole M. 
Published: May 2022

ABSTRACTNutrient availability regulates the C. elegans life cycle as well as mitochondrial physiology. Food deprivation significantly reduces mitochondrial genome (mtDNA) number and leads to aging-related phenotypes. Here, we demonstrate that the bZIP protein ATFS-1, a mediator of the mitochondrial unfolded protein response (UPRmt), is required to promote growth and establish a functional germline following prolonged starvation. Surprisingly, we found that the recovery of mtDNA copy number and development following starvation required mitochondrial-localized ATFS-1 but not its nuclear transcription activity. Lastly, we found that the insulin-like receptor DAF-2, functions upstream of ATFS-1 to modulate mtDNA content. We demonstrate that reducing DAF-2 activity represses ATFS-1 nuclear function while causing an increase in mtDNA content partly mediated by mitochondrial-localized ATFS-1. Combined, our data indicate the importance of the UPRmt in recovering mitochondrial mass and suggests that atfs-1-dependent mtDNA replication precedes mitochondrial network expansion following starvation.
Combined omics unravels the molecular mechanism of golden-leaf coloration in Koelreuteria paniculata ‘jinye’
Authors: Guo Ting , Wu Ruqian , Yang Xiong , Huang Sai , Miao Deyu , Chen Tingting , Xue Yinxuan , Li Juan , Gao Kai , Guo Bin , An Xinmin 
Published: May 2022

AbstractKoelreuteria paniculata is widely distributed in Asia and introduced to Europe and North America. K. paniculata ‘jinye’ is a mutant variety used in landscaping that has a golden leaf color phenotype. Although similar leaf color variants occur in plants, little is known of the underlying mechanism. We performed physiological, anatomical, microRNA sequencing, transcriptomic, and metabolomic analyses of the golden leaf variation in the mutant. Compared with the original green cultivar, the golden leaf mutant exhibited 76.05% and 44.32% decreased chlorophyll a (Chl a) and chlorophyll b (Chl b) contents, respectively, and significantly increased carotenoid content. Analysis of leaf ultrastructure revealed an abnormal chloroplast morphology and fewer lamellae in the mutant. Fifty-nine differentially expressed genes (DEGs), forty transcription factors (TFs) and forty-nine differentially expressed miRNAs (DEmiRs) involved in pigment metabolism, chloroplast development, and photosynthesis were identified. The GLK and petC genes were downregulated and are involved in chloroplast development and chlorophyll synthesis, respectively. The upregulated PSY and PDS genes, and the downregulated NCED gene promote carotenoid accumulation. A variety of chalcones and flavonols were upregulated in the mutant. Consequently, the carotenoid to chlorophyll ratio increased by more than 75%, and the accumulation of chalcones and flavonols was responsible for the golden leaf phenotype of the mutant K. paniculata.
Using nanopore sequencing to obtain complete genomes from saliva samples
Authors: Baker Jonathon L. 
Published: May 2022

SummaryObtaining complete, high-quality reference genomes is essential to the study of any organism. Recent advances in nanopore sequencing, as well as genome assembly and analysis methods, have made it possible to obtain complete bacterial genomes from metagenomic (i.e. multispecies) samples, including those from the human microbiome. In this study, methods are presented to obtain complete bacterial genomes from human saliva using complementary Oxford Nanopore (ONT) and Illumina sequencing. Applied to 3 human saliva samples, these methods resulted in 11 complete bacterial genomes: 3 Saccharibacteria clade G6 (aka Ca. Nanogingivalaceae HMT-870), 1 Saccharibacteria clade G1 HMT-348, 2 Rothia mucilaginosa, 2 Actinomyces graevenitzii, 1 Mogibacterium diversum, 1 Lachnospiraceae HMT-096, 1 Lancefieldella parvula, and one circular chromosome of Ruminococcaceae HMT-075 (which likely has at least 2 chromosomes). The 4 Saccharibacteria genomes, as well as the Actinomyces graeventizii genomes, represented the first complete genomes from their respective bacterial taxa. Aside from the complete genomes, the assemblies contained 147 contigs of over 500,000 bp each and thousands of smaller contigs, together representing many additional draft genomes including many which are likely near-complete. The complete genomes enabled highly accurate pangenome analysis, which identified unique and missing features of each genome compared to its closest relatives with complete genomes available in public repositories. These features provide clues as to the lifestyle and ecological role of these bacteria within the human oral microbiota, which will be particularly useful in designing future studies of the specific taxa that have never been isolated or cultivated.
Effects of Familial Alzheimer’s Disease Mutations on the Folding Free Energy and Dipole-Dipole Interactions of the Amyloid β-Peptide
Authors: Davidson Darcy S. , Kraus Joshua A. , Montgomery Julia M. , Lemkul Justin A. 
Published: May 2022

AbstractFamilial Alzheimer’s disease (FAD) mutations of the amyloid β-peptide (Aβ) are known to lead to early onset and more aggressive Alzheimer’s disease. FAD mutations such as “Iowa” (D23N), “Arctic” (E22G), “Italian” (E22K), and “Dutch” (E22Q) have been shown to accelerate Aβ aggregation relative to the wild-type (WT). The mechanism by which these mutations facilitate increased aggregation is unknown, but each mutation results in a change in net charge of the peptide. Previous studies have used nonpolarizable force fields to study Aβ, providing some insight into how this protein unfolds. However, nonpolarizable force fields have fixed charges that lack the ability to redistribute in response to changes in local electric fields. Here, we performed polarizable molecular dynamics (MD) simulations on the full-length Aβ42 of WT and FAD mutations and calculated folding free energies of the Aβ15-27 fragment via umbrella sampling. By studying both the full-length Aβ42 and a fragment containing mutations and the central hydrophobic cluster (residues 17-21), we were able to systematically study how these FAD mutations impact secondary and tertiary structure and the thermodynamics of folding. Electrostatic interactions, including those between permanent and induced dipoles, affected sidechain properties, salt bridges, and solvent interactions. The FAD mutations resulted in shifts in the electronic structure and solvent accessibility at the central hydrophobic cluster and the hydrophobic C-terminal region. Using umbrella sampling, we found that the folding of the WT and E22 mutants are enthalpically driven, whereas the D23N mutant is entropically driven, arising from a different unfolding pathway and peptide-bond dipole response. Together, the unbiased, full-length and umbrella sampling simulations of fragments reveal that the FAD mutations perturb nearby residues and others in hydrophobic regions to potentially alter solubility. These results highlight the role electronic polarizability plays in amyloid misfolding and the role of heterogeneous microenvironments that arise as conformational change takes place.
Impact of COVID-19 on people with Down syndrome in Japan based on regional differences frequency of emergency declarations
Authors: Kojima Michio 
Published: May 2022

Purpose
The purpose of this study was to clarify the impact of adults with Down syndrome (DS) on COVID-19 and the status of efforts for new normal in Japan through a Web survey.

Design/methodology/approach
Parents’ associations’ representatives sent requests to members aged 18 years or older inviting them to participate in an Internet survey. A total of 141 people cooperated, and 126 people were included in the analysis.

Findings
As a result of examining the number of times the state of emergency was declared and its impact on COVID-19, the degree of anxiety felt when hearing information about new coronavirus infections on television or the internet was significantly higher in subjects for whom the state of emergency was declared four times than in subjects for whom the state of emergency was declared two and three times in the region. This was significantly higher than that of the subjects in the areas where the state of emergency had been declared four times and significantly lower than that of the subjects in the areas where the state of emergency had been declared one time for “smiling”. The results suggest that the effects on physical and mental health, although limited, are influenced by the number of times the state of emergency was declared. From the analysis of the free text, it was inferred that some, but not all, of the subjects with DS, had their physical and mental state affected by COVID-19 to the extent that they required medical care.

Originality/value
This study clarified the psychosomatic effects of COVID-19 in people with DS in adulthood, which has not yet been fully clarified in the world. To the best of the authors’ knowledge, this is the first study in Japan to clarify the physical and mental effects of COVID-19 on people with DS and the status of new normal initiatives.
On the relationship between procedural justice and organizational citizenship behavior: a test of mediation and moderation effects
Authors: Nguyen Phan Dinh , Tran Lobel Trong Thuy 
Published: May 2022

PurposeThis study conceptualizes job engagement and satisfaction as a crucial mediating mechanism in the relationship between procedural justice and citizenship behavior at individual level (OCB) under the boundary conditions of perceived supervisor support (PSS) and rewards and recognition (RR).Design/methodology/approachThe survey data were obtained from two periods of time. To reduce the potential bias, the authors approached respondents from different business units and measured RR and OCB from different points of time. The authors assessed the path significance at 95% bias-corrected confidence interval or more by the PLS algorithm and bootstrapping statistics.FindingsUsing an import-export company data, this study substantiates a positive effect of the proposed mediational mechanism of job engagement and satisfaction. In addition, the authors substantiate moderating roles of PSS and RR in the relationships between procedural justice and job satisfaction and, between job engagement and OCB, respectively.Originality/valueThis study is an important extension in enhancing the procedural justice and OCB relationship. The results do not only underscore the contributions of job engagement and satisfaction as vital mediators to the assumed relationship but also lend support to the inclusion of the moderating effects of PSS and RR.
Human resource development in SMEs in a context of labor shortage: a profile analysis
Authors: Deschênes Andrée-Anne 
Published: May 2022

Purpose
The purpose of this paper is to examine small and medium-sized enterprises’ (SMEs) level of participation in human resource development activities during a labor shortage. Drawing on human capital theory, it examines whether SMEs’ profiles, determined according to their participation in different types of training activities, relate to perceived benefits of training, barriers to participation in training and learning culture.

Design/methodology/approach
This study applies latent profile analysis (LPA) to 10 training practices of 427 SMEs in Quebec, Canada.

Findings
The LPA distinguished four profiles of SMEs, reflecting differing capacities for mobilizing training resources during a labor shortage. These four profiles show differences with regard to perceived training benefits, barriers to participation in training and learning culture.

Originality/value
To the best of the authors’ knowledge, this study is among the first to focus on the specific ability of SMEs to invest in their human capital in the unique and recent context of a labor shortage.
Fractional order interval optimization method based on perturbation bound and gamma function of a non-equidistant ROGM
Authors: Lian Yufeng , Feng Wenhuan , Li Pai , Lei Qiang , Ma Haitao , Sun Hongliang , Li Binglin 
Published: May 2022

PurposeThe purpose of this paper is to propose a fractional order optimization method based on perturbation bound and gamma function of a DGM(r,1).Design/methodology/approachBy analyzing and minimizing perturbation bound, the sub-optimal solution on fractional order interval is obtained through offline solving without iterative calculation. By this method, an optimized fractional order non-equidistant ROGM (OFONEROGM) is applied in fitting and prediction water quality parameters for a surface water pollution monitoring system.FindingsThis method can narrow fractional order interval in this work. In a surface water pollution monitoring system, the fitting and prediction performances of OFONEROGM are demonstrated comparing with integer order non-equidistant ROGM (IONEROGM).Originality/valueA method of offline solving the sub-optimal solution on fractional order interval is proposed. It can narrow the optimized fractional order range of NEROGM without iterative calculation. A large number of calculations are eliminated. Besides that, optimized fractional order interval is only related to the number of original data, and convenient for practical application. In this work, an OFONEROGM is modeled for predicting water quality trend for preventing water pollution or stealing sewage discharge. It will provide guiding significance in water quality parameter fitting and predicting for water environment management.
A theoretical framework of smart supply chain innovation for going global companies: a multi-case study from China
Authors: Liu Weihua , Liang Yanjie , Lim Ming K. , Long Shangsong , Shi Xiaoran 
Published: May 2022

PurposeThis study explores the influencing factors of smart supply chain innovation (SSCI) for going global companies and designs a theoretical framework.Design/methodology/approachThis paper is a multi-case study that includes a combination of exploratory and explanatory case studies.FindingsFirst, the authors find that SSCI is embodied in product development and supply chain empowerment, which represent exploitative innovation and explorative innovation, respectively. Meanwhile, supply chain empowerment has a positive impact on product development. Second, the going global policy affects the transformation of supply chain empowerment to SSCI practices. Third, in terms of exploitative innovation, personalized demand positively affects SSCI through product development. Finally, explorative innovation, including emerging technology application and supply chain ecologicalization, has a positive effect on supply chain empowerment and thereby affects SSCI.Originality/valueSupply chain innovation in the context of a smart economy has gained great popularity. This study sheds light on the influencing factors and mechanisms of SSCI from the exploitative and explorative aspects of innovations.
Supporting participatory innovation during the COVID-19 pandemic: a comparative study of enterprise social media use
Authors: Abhari Kaveh , Pesavento Michael , Williams David 
Published: May 2022

PurposeThe need for accelerating innovation is exacerbated as organizations struggle to either adapt or perish in this unforgiving condition due to the COVID-19 disruption. To address this issue, many organizations have embraced employee-driven participatory innovation to survive and thrive albeit the uncertainties. This study aims to investigate the role of enterprise social media (ESM) in supporting and facilitating these efforts.Design/methodology/approachThis study first identified the underlying mechanisms that allow ESM use to foster and maintain participatory innovation and then reexamined how these mechanisms played out during the COVID-19 lockdown restrictions. The data was collected through a questionnaire in two phases, before and during work-from-home mandates, and the results were analyzed and compared to capture similarities and differences.FindingsThe results revealed that innovation culture and management support mediated the effects of ESM use on three measures of innovation productivity in both conditions. Interestingly, the effect of ESM use was more prominent in driving innovation in the work-from-home condition. This effect was not limited to the direct effect of ESM use on innovation productivity but on innovation culture and management support as well.Originality/valueThe results suggest that ESM offer a potentially useful path to support and enable employees to participate in the innovation processes, especially when they work remotely or in a distributed team. More generally, this paper should be of interest to researchers and practitioners interested in understanding, implementing and evaluating enterprise social software applications and encouraging employee-driven participatory innovation.
Wrestling with racism and anti-blackness: confronting legacies of coloniality in teacher education programs
Authors: Daniel CarolAnn 
Published: May 2022

Purpose
This paper argues that to preserve black lives, teacher educators and teacher candidates need to develop a decolonial lens. A decolonial lens can provide clarity in understanding how the centering of Western epistemic perspectives perpetuate hierarchies and processes of racialization and invisibilized structures of domination that (re)produce differential learning experiences and outcomes for black students. This study aims to build on prior research to help teacher candidates more effectively recognize and challenge racism and anti-blackness in their schools and teaching practices.

Design/methodology/approach
In this paper, the author discusses how racism and anti-blackness are perpetuated in schooling and why teacher educators must address them in our work with teacher candidates. Drawing upon existing literature on teacher education, my experiences as a teacher educator and social justice scholar, and insights from the decolonial scholarship, the discusses the importance of a decolonial lens for disrupting racism and anti-blackness, and I offer examples of how teacher educators and teacher candidates can engage in this work.

Findings
Multicultural education has done little to change the conditions of black students in schools. While most teacher education programs have made efforts to become more oriented toward social justice, there is a wide gap between program goals and teachers who can work effectively with the diversity of students that they serve.

Practical implications
This paper outlines an approach that teacher educators can use to further develop an antiracist decolonial teaching and research agenda and support teacher candidates regardless of their racial/ethnic group.

Social implications
A decolonial analysis can help teachers develop a better understanding of the structural and school inequalities that create disparate outcomes for black students and how to intervene. This is urgently necessary, as schooling remains a site of non-belonging and marginalization for black children and youth.

Originality/value
This paper offers a new race-conscious approach to disrupt systemic racism and anti-blackness in education.
The role of proximity in omnichannel customer experience: a service logic perspective
Authors: Dalla Pozza Ilaria 
Published: May 2022

PurposeThis article proposes a new theoretical background against which to measure customer experience for omnichannel service deliveries and communications based on the concept of proximity. This represents a first step in developing a new measurement approach for omnichannel customer experience.Design/methodology/approachThe methodological approach is based on literature review and theory development. Various streams of literature are integrated on the basis of their interactionist nature (service logic, psychological distance theory, and omnichannel customer experience literature), and theory is developed based thereon.FindingsSuccessful omnichannel service deliveries and communications should build proximity with the customer during interactions at the different touchpoints. Proximity represents the value-in-use for the customer, who is coproducer of value at each interaction. Proximity can be applied to all touchpoints, thus strengthening seamlessness for omnichannel service deliveries and communications.Originality/valueThis research advances knowledge by integrating the concepts of omnichannel and proximity under the lenses of service logic. The author proposes a new theoretical background for the measurement of omnichannel customer experience that contributes to the literature. In modern omnichannel service deliveries and communications, a measurement approach based on proximity fulfills the need to reconcile customer experiences at both remote and physical touchpoints for a holistic and coherent customer experience. Use of the four proximity dimensions (social, temporal, spatial, and hypothetical) gives flexibility to managers to build proximity across remote and physical touchpoints in different industries.
Understanding viewers' information-sharing in live-streaming based on a motivation perspective
Authors: Chou Shih-Wei , Hsieh Ming-Chia , Pan Hui-Chun 
Published: May 2022

PurposeThis study aims to understand how information-sharing in live-streaming is formed through a motivational perspective. The authors provide a framework to explain how live-streaming services and attachment affect viewers' information-sharing decision.Design/methodology/approachThis study uses a survey-based method to collect data and partial least squares to analyze them.FindingsThe proposed hypotheses are largely supported. The results show that information-sharing intention is influenced by both attachment to a creator and attachment to a group. These attachments are positively affected by live-streaming services. The findings contribute to live-streaming literature by conceptualizing motivation and motivational feedback as service and attachment respectively.Practical implicationsThe findings suggest that live-streaming managers emphasize social-technical features and relationship development with others (creators, group members) to motivate viewers' participation in live-streaming.Originality/valueThis study addresses the gap of lacking a systematic consideration of motivation in the live-streaming context. As such, the authors conducted empirical research that describes the information-sharing through the motivation from service and feedback from attachment.