bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive potential of age‐group cut‐off values of N‐terminal pro‐brain natriuretic peptide in Kawasaki disease
Authors: Hirai Seiko , Nakamura Takahiro , Misawa Masahiro 
Published: September 2022

AbstractBackgroundThe relationship between serum N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and the clinical features of patients with Kawasaki disease (KD) has been the subject of research. Recent studies have revealed that serum NT‐proBNP levels vary with age. We therefore aimed to determine the utility of age‐stratified cut‐off values for NT‐proBNP in predicting coronary artery lesions (CALs) in patients with KD.MethodsWe retrospectively assessed the electronic medical records of patients who were hospitalized for KD or incomplete KD between January 1, 2015, and August 31, 2019. The patients were divided into high and normal NT‐proBNP groups using age‐stratified cut‐off based on serum NT‐proBNP levels measured immediately before KD treatment initiation.ResultsThe study comprised 242 cases, including 71 and 171 cases in high and normal NT‐proBNP groups, respectively. Thirty‐seven of them (15.3%) were resistant to treatment; 15 (6.2%) had CALs, with a higher incidence in the high NT‐proBNP group than in the normal NT‐proBNP group. On multivariate logistic regression analysis, high serum NT‐proBNP levels were significantly correlated to CALs (OR, 9.76; 95% CI, 2.64–36.2). On logistic regression analysis to compare the predictive accuracy of the age‐stratified and fixed cut‐off for CALs, the age‐stratified cut‐off values showed a larger area under the receiver operating characteristic curve than fixed cut‐off value.ConclusionsBased on age‐stratified cut‐off values for serum NT‐proBNP, high NT‐proBNP levels at the time of diagnosis were significantly associated with CALs in patients with KD. Higher predictive accuracy for CALs of the age‐stratified cut‐off values was also suggested.
Susceptibility of Italian olive cultivars to various Colletotrichum species associated with fruit anthracnose
Authors: Riolo Mario , Pane Antonella , Santilli Elena , Moricca Salvatore , Cacciola Santa Olga 
Published: September 2022

AbstractFruit anthracnose caused by Colletotrichum species is a major disease of olive (Olea europaea) worldwide. In this study, we tested in vitro the susceptibility of eight widely grown Italian olive cultivars and one Spanish cultivar to five Colletotrichum species. The Italian cultivars were Carolea, Cassanese, Coratina, Dolce Agogia, Frantoio, Leccino, Ottobratica and Sant'Agostino. The Spanish cultivar, included as a reference, was Picual. The five Colletotrichum species, included in pathogenicity tests, were C. acutatum, C. gloeosporioides, C. godetiae, C. karsti and C. nymphaeae. Olive drupes at comparable ripening stage were wound‐inoculated with a conidial suspension and the severity of infections was rated at various time intervals after inoculation using a scale of 0 to 6. The results were expressed in terms of relative area under disease progress curve (rAUDPC). C. acutatum was the most aggressive while C. karsti was the least aggressive among the Colletotrichum species tested. Frantoio and Leccino were the least susceptible cultivars while Ottobratica, Coratina and Carolea were the most susceptible to all Colletotrichum species. Separate experiments aimed to evaluate the effect of both inoculation method and drupe ripening stage on the interaction between Colletotrichum species and olive cultivars. Only C. acutatum and C. nymphaeae induced symptoms in nonwounded drupes. In general, the disease severity in green drupes was significantly lower than in mature drupes; however, the rankings of olive cultivars for their susceptibility to Colletotrichum species on both green and mature drupes showed similar trends.
Web‐based assessment of social and emotional competence in the late elementary grades
Authors: McKown Clark , Russo‐Ponsaran Nicole , Karls Ashley 
Published: September 2022

AbstractThis paper presents evidence of the score reliability, factor structure, criterion‐related validity, and measurement equivalence of a web‐based assessment of several important social and emotional competencies for children in fourth through sixth grades. The assessment, SELweb LE (Late Elementary), is designed to measure children's understanding of other's thoughts and feelings, their ability to solve social problems, and their ability to engage in self‐control. SELweb LE satisfies a need for a direct assessment that measures theoretically relevant social and emotional competencies specifically for youth in the late elementary grades. The competencies measured are associated with youth outcomes, are reflected in state education standards, and are the targets of instruction in widely used social and emotional learning (SEL) curricula. Analyses support SELweb LE's factor structure, score reliability, measurement equivalence, and convergent, discriminant, and criterion‐related validity. More broadly, evidence supports the use of SELweb LE to characterize student competencies.
Outcome of cranial cruciate ligament replacement with an enhanced polyethylene terephthalate implant in the dog: A pilot clinical trial
Authors: Johnson Tiffany A. , Conzemius Michael G. 
Published: September 2022

AbstractObjectiveTo assess the 6‐month outcome and survival of enhanced polyethylene terephthalate (PET) implants as a replacement for the cranial cruciate ligament (CCL) in dogs with spontaneous CCL disease (CCLD).Study designPilot, prospective case series.AnimalsTen client‐owned large breed dogs with unilateral spontaneous CCLD.MethodsDogs were evaluated before and 6 months after intra‐articular placement of a PET implant with the Liverpool Osteoarthritis in Dogs questionnaire and force platform gait analysis. Arthroscopy was performed 6 months after surgery to visually assess implant integrity.ResultsScores on owner questionnaires and limb asymmetry improved in all dogs that reached the 6‐month time point, by 51.7% (p = .008) and 86% (p = .002), respectively. The PET implant appeared intact and functioning in two stifles, partially intact and functioning in four stifles and completely torn in three stifles. One dog had an implant infection and was removed from the study. Evidence of deterioration and tearing occurred in the midbody of the implant.ConclusionAlthough function improved over the course of this study, only 2/10 implants appeared intact 6 months after placement.Clinical significanceImplant survivability prohibits further clinical investigation using this implant.
Barriers and facilitators to cancer clinical trial enrollment and participation among rural populations: a scoping review protocol
Authors: Palokas Michelle , Christian Robin , Hinton Elizabeth , Duhe Roy , Thomas Toms , Torres Elisa , Jordan Christina , Gordy Xiaoshan Z. , Sharma Manvi , Gomillia Courtney , Stefanek Michael , Robinson William “Rusty” 
Published: September 2022

ABSTRACT

Objective:
The objective of this scoping review is to identify barriers and facilitators related to cancer clinical trial enrollment and participation among rural populations.

Introduction:
Advancing the effectiveness of cancer treatment and increasing early detection of cancer relies on enrollment and participation of individuals in cancer clinical trials. Lack of enrollment and participation in trials is a concern, and there is evidence that individuals living in rural areas are unlikely to participate in such trials. Information on barriers to, and facilitators of, enrollment and participation in cancer clinical trials is needed for the development of evidence-based interventions to increase the enrollment and participation of rural populations.

Inclusion criteria:
The review will consider studies on adults aged 18 years or older living in rural areas. Studies that report on barriers and facilitators to enrollment and participation in cancer clinical trials, including both cancer therapeutic and cancer early detection trials, will be included in the review. The review will consider quantitative, qualitative, and text and opinion papers for inclusion.

Methods:
The search strategy will aim to locate published primary studies, reviews, and opinion papers, the latter including those by professional oncology organizations. The databases to be searched include MEDLINE, CINAHL, Embase, Web of Science, and Cochrane Library. Gray literature databases will also be searched. Two independent reviewers will retrieve full-text studies and extract data. The results will be presented in diagrammatic format with a narrative summary.
High-Pressure Laminar Flame Speeds and Markstein Lengths of Syngas Flames Diluted in Carbon Dioxide and Helium
Authors: Turner Mattias A. , Petersen Eric L. 
Published: September 2022

Abstract
New laminar flame speed and burned-gas Markstein length data for H2–CO–O2–CO2–He mixtures have been measured from spherically expanding flames. Experiments were conducted at 10 atm and room temperature for H2:CO ratios ranging from 2:1 to 1:4 and for overall CO2 mole fractions from 0% to 30%. CO2 dilution had little effect on Markstein length, but CO2 dilutions of 10%, 20%, and 30% caused average reductions in flame speed of 47%, 73%, and 89%, respectively, regardless of H2:CO ratio. The study was designed to isolate the dilution effect of CO2 on flame speed, and a detailed analysis using the FCO2 method was used to show that the chemical-kinetic participation of CO2 was responsible for up to 20% of the reduction in flame speed. Hence, the majority (80% or more) of the reduction in flame speed due to CO2 is from the thermal effect. Accurate flame speed predictions were produced by five different chemical kinetics mechanisms for most conditions, with the slight exception of high-CO, high-CO2 mixtures. A thorough sensitivity analysis highlighted the larger effect of CO2 dilution on the important kinetics reactions than the effect of changing H2:CO. Sensitivity analysis also showed that the chain branching reaction H2O + O ⇌ OH + OH could be modified (albeit beyond its uncertainty) to achieve more accurate flame speed predictions, but also indicated that further improvement of flame speed modeling would require changes to many lesser reactions.
New Methods for Preparation of the Monofluorosubstituted Derivative of the closo-Borate Anion [2-B10H9F]2–, Its Properties, and Analysis of Its Reactivity
Authors: Neumolotov N. K. , Selivanov N. A. , Bykov A. Yu. , Klyukin I. N. , Novikov A. S. , Zhdanov A. P. , Zhizin K. Yu. , Kuznetsov N. T. 
Published: September 2022

Abstract
New methods for the preparation of a monofluoro-substituted derivative of the closo-decaborate anion [2-B10H9F]2– have been developed. Various synthetic strategies have been used, where Bu4NF, Me4NF, KF/18-crown-6, and NH4HF2 act as sources of the F– anion. A feature of the proposed methods is the absence of HF as a fluorinating agent in the reaction mixture. In the course of the work, the optimal conditions for the synthesis of [2-B10H9F]2– have been determined and the reaction products have been characterized. Using theoretical modeling methods, the main indices of reactivity of monofluorinated derivatives of the closo-decaborate anion have been calculated. The influence of solvation effects on the nucleophilicity of target objects has been studied. The structure of the obtained compounds has been confirmed by 1H, 11B, 19F NMR spectroscopy, and ESI mass spectroscopy.
Use of artificial intelligence to assess the risk of coronary artery disease without additional (non-invasive) testing: validation in a low-risk to intermediate-risk outpatient clinic cohort
Authors: Eurlings Casper G M J , Bektas Sema , Sanders-van Wijk Sandra , Tsirkin Andrew , Vasilchenko Vasily , Meex Steven J R , Failer Michael , Oehri Caroline , Ruff Peter , Zellweger Michael J , Brunner-La Rocca Hans-Peter 
Published: September 2022

ObjectivesPredicting the presence or absence of coronary artery disease (CAD) is clinically important. Pretest probability (PTP) and CAD consortium clinical (CAD2) model and risk scores used in the guidelines are not sufficiently accurate as the only guidance for applying invasive testing or discharging a patient. Artificial intelligence without the need of additional non-invasive testing is not yet used in this context, as previous results of the model are promising, but available in high-risk population only. Still, validation in low-risk patients, which is clinically most relevant, is lacking.DesignRetrospective cohort study.SettingSecondary outpatient clinic care in one Dutch academic hospital.ParticipantsWe included 696 patients referred from primary care for further testing regarding the presence or absence of CAD. The results were compared with PTP and CAD2 using receiver operating characteristic (ROC) curves (area under the curve (AUC)). CAD was defined by a coronary stenosis >50% in at least one coronary vessel in invasive coronary or CT angiography, or having a coronary event within 6 months.Outcome measuresThe first cohort validating the memetic pattern-based algorithm (MPA) model developed in two high-risk populations in a low-risk to intermediate-risk cohort to improve risk stratification for non-invasive diagnosis of the presence or absence of CAD.ResultsThe population contained 49% male, average age was 65.6±12.6 years. 16.2% had CAD. The AUCs of the MPA model, the PTP and the CAD2 were 0.87, 0.80, and 0.82, respectively. Applying the MPA model resulted in possible discharge of 67.7% of the patients with an acceptable CAD rate of 4.2%.ConclusionsIn this low-risk to intermediate-risk population, the MPA model provides a good risk stratification of presence or absence of CAD with a better ROC compared with traditional risk scores. The results are promising but need prospective confirmation.
Extracurricular work experience and its association with training and confidence in emergency medicine procedures among medical students: a cross-sectional study from a Norwegian medical school
Authors: Scott Remi William , Fredriksen Knut 
Published: September 2022

ObjectiveProficiency in basic emergency procedures is important for junior doctors, but the amount of practical exposure may vary. We studied the association between students’ extracurricular healthcare-related (ECHR) work experience and self-reported practical training and confidence in selected emergency medicine procedures.Study designCross-sectional study.Materials and methodsMedical students and first-year graduates answered a Likert-based questionnaire probing self-reported amount of exposure to (‘training amount’) and confidence with selected emergency medicine procedures. Participants also reported ECHR work experience, year of study, previous healthcare-related education, military medic training and participation in the local student association for emergency medicine (Tromsø Acute Medicine Students’ Association (TAMS)). Differences within variables were analysed with independent samples t-tests, and correlation between training amount and confidence was calculated. Analysis of covariance and mixed models were applied to study associations between training amount and confidence, and work experience (primary outcomes) and the other reported factors (secondary outcomes), respectively.Results539 participants responded (70%). Among these, 81% had ECHR work experience. There was a strong correlation (r=0.878) between training amount and confidence. Work experience accounted for 5.9% and 3.5% of the total variance in training amount and confidence (primary outcomes), and respondents with work experience scored significantly higher than respondents without work experience. Year of study, previous education, military medic training and TAMS participation accounted for 49.3%, 8.7%, 6.8% and 23.6%, and 58.5%, 5.1%, 4.7% and 12.3% of the total variance in training amount and confidence, respectively (secondary outcomes). Cohen’s D was 0.48 for training amount and 0.32 for confidence level, suggesting medium and weak medium-sized associations with work experience, respectively.ConclusionECHR work experience is common among medical students and was associated with more training amount and higher confidence in the procedures. Year of study, previous relevant education and TAMS participation, but not military medic training, were also significantly associated with training amount and confidence.
Impact of gestational hypertension and pre-eclampsia on preterm birth in China: a large prospective cohort study
Authors: An Hang , Jin Ming , Li Zhiwen , Zhang Le , Li Hongtian , Zhang Yali , Ye Rongwei , Li Nan 
Published: September 2022

ObjectiveTo investigate the impact of gestational hypertension and pre-eclampsia on preterm birth.DesignThe data were collected from the China–US Collaborative Project for Neural Tube Defect Prevention; this was a large population-based cohort study.Setting and participantsWe selected participants registered in two southern provinces, for whom we had exact information on gestational blood pressure and pregnancy outcomes, and who were not affected by chronic hypertension. In total, 200 103 participants were recruited from 1993 to 1995.Outcome measuresPreterm birth was defined as a singleton pregnancy and birth before 37 gestational weeks.ResultsThe incidences of gestational hypertension and pre-eclampsia were 5.47% and 5.44%, respectively, for women who gave birth at full term, and 5.63% and 7.33%, respectively, for those who gave birth preterm. After adjusting for potential confounders, the risk ratios (RRs) of preterm birth in women with gestational hypertension and pre-eclampsia were 1.04 (95% CI 0.98 to 1.11) and 1.39 (95% CI 1.25 to 1.55), respectively. The associations were stronger for early-onset (<28 weeks of gestation) gestational hypertension (adjusted RR=2.13, 95% CI 1.71 to 2.65) and pre-eclampsia (adjusted RR=8.47, 95% CI 5.59 to 12.80).ConclusionsPre-eclampsia was associated with a higher risk of preterm birth. The early-onset gestational hypertension and pre-eclampsia were associated with more severe risks than late-onset conditions.
Multicentre evaluation of renal impairment in thoracic surgery (MERITS): a retrospective cohort study
Authors: Naruka Vinci , McKie Mikel Alexander , Ahmadi Navid , Pama E A Claudia , Coonar Aman S , Collaborators MERITS 
Published: September 2022

ObjectivesTo measure the unit-level variation in Acute Kidney Injury (AKI) incidence post-thoracic surgery over a contemporary 1-year period. Secondary aims include examining the associations with sex, age group, operation type, length of stay and mortality.DesignA multicentre, observational, retrospective study in thoracic surgery.Setting17 of 35 Society for Cardiothoracic Surgery of Great Britain and Ireland (SCTS) units participated. The student wing, known as SCTS STUDENTS, supported data collection.ParticipantsOverall, 15 229 patients were collected of which 15 154 were included for analysis after exclusions. All patients (age≥18 years) undergoing any thoracic surgery from 1 April 2016 to 31 March 2017 were included. For analysis, we excluded patients with preoperative end-stage renal failure and those with incomplete data.Main outcome measuresThe primary outcome is the incidence of AKI within 7 days of the procedure or discharge date if earlier. Secondary outcomes include assessing associations with patient demographics (age, sex), type of procedure (open and minimally invasive), length of stay and mortality.ResultsOut of 15 154 patients AKI was diagnosed in 1090 patients (7.2%) within 7 days of surgery with AKI stage 1 (4.8%), stage 2 (1.7%) and stage 3 (0.7%). There was a statistically significant variation in AKI incidence between units from 3.1 to 16.1% (p<0.05). Significant differences between AKI and non-AKI were found in post-operative length of stay (7 vs 3 days, p<0.001), 30-day mortality (9 vs 1.6%, p<0.001), 90-day mortality (14.7 vs 4.4%, p<0.001) and 1-year mortality (23.1 vs 12.2 %, p<0.001).ConclusionsFollowing thoracic surgery, AKI incidence ranged from 3.1% to 16.1% between units (p<0.05) with associations between AKI and both length of stay and mortality. We propose AKI as a suitable comparative and absolute quality measure in thoracic surgery. Reducing rates of AKI may improve patient outcomes, length of stay and reduce costs.
Acupuncture for emotional disorders in patients with inflammatory bowel disease: a systematic review protocol
Authors: Zhou Yuan-Fang , Zhang Gui-Long , Sun Ning , Wang Zhong-Quan , Ye Xiang-Yin , Xiong Jian , Deng Xiao-Dong , Lin Xin , Zhang Pei , Zheng Hao , Zhang Yong , Yang Kun , Gao Ze-Da , Sun Rui-Rui , Liang Fan-Rong 
Published: September 2022

IntroductionEmotional disorders are often observed in inflammatory bowel disease (IBD). IBD with emotional disorders leads to poor quality of life. This systematic review aims to assess the effectiveness of acupuncture in patients with IBD with emotional disorders.Methods and analysisNine electronic databases, including Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Allied and Complementary Medicine Database, Cumulative Index to Nursing & Allied Health Literature, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database and Wanfang Database, will be searched from inception to October 2021 without language restriction. The grey literature containing conference proceedings, as well as systematic reviews listed in the reference of definite publications, will also be retrieved. Randomised controlled trials either in English or Chinese reporting acupuncture therapy for IBD with emotional disorders will be included. The primary outcome is changes of emotional functioning outcomes. The Colitis Activity Index, Crohn’s Disease Activity Index, C reactive protein and adverse events will be assessed as the secondary outcomes. More than two assessors will conduct the study retrieval and selection, as well as the data extraction and evaluation of the risk of bias. Data synthesis will be performed using a random-effects model based on the results of heterogeneity. Data analysis will be performed using RevMan software (V.5.4). Moreover, the dichotomous data will be presented as risk ratios, and the continuous data will be calculated using weighted mean difference or standard mean difference.Ethics and disseminationThis systematic review contains no individual patient data; thus, ethical approval is not required. Moreover, this review will be disseminated in a peer-reviewed journal or relevant conference.PROSPERO registration numberCRD42020176340.