bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clonazolam Intoxication Case Report
Authors: Moore Caley , Hammers Jennifer , Marshall Pamela 
Published: October 2022

Abstract
Clonazolam is a derivative of the Xanax active ingredient, alprazolam. Classified as a designer benzodiazepine, clonazolam availability has been rising because of its circulation on illegal internet drug markets and marginal cost in comparison to its parent analogs. Clonazolam's accessibility encourages abuse prevalence and use of designer benzodiazepines. In our case, a 14-year-old male was found unresponsive the morning after ingesting multiple tablets believed to be Xanax. Toxicology testing indicated 140 ng/mL of 8-aminoclonazolam, a clonazolam metabolite, in the decedent's system. Alprazolam was not identified. Pathological analysis determined cerebral and respiratory depression to be the mechanism of death, resulting from acute clonazolam intoxication. This case presents the first death induced by clonazolam alone. Current literature identifies a gap in designer benzodiazepine confirmatory testing and a lack of awareness within the forensic and medical communities. Knowledge of designer benzodiazepines is needed to better understand their potency and to help prevent future intoxications. We present this case to aid in the recognition of novel benzodiazepines by medical examiners and coroners, to encourage their consideration in suspected Xanax and other substance related investigations, and to be aware of the capabilities of toxicological testing to improve novel benzodiazepine identification and subsequent interpretation.
The role of consumer characteristics on cultural consumption tendency
Authors: Ozkan Feyza Nur , Kurtulus Sema 
Published: October 2022

PurposeThis study aims to identify the role of consumer characteristics in cultural consumption tendencies. Additionally, the study examines whether country differences and prior experience in the country affect consumers' cultural consumption tendencies.Design/methodology/approachThe effects of cosmopolitanism, consumer ethnocentrism, individual innovativeness, and lifestyle on cultural consumption tendencies were tested. Moreover, we assess whether country type and prior experience are differentiating factors for cultural consumption tendencies. To this end, two countries – the USA and South Korea, representing Western and Eastern cultures, respectively – were selected to achieve comparable results in two different cultures. The research data were collected from 775 people using an online survey method and analyzed using path analysis and an independent samples t-test.FindingsConsumer characteristics affect cultural consumption tendencies. These effects are culture-specific and cultural product-specific. Cosmopolitanism has a positive impact on cultural consumption tendencies, while consumer ethnocentrism has a negative impact. Individual innovativeness and lifestyle partially affected cultural consumption tendencies. Notably, these effects differ by country type. However, cultural consumption tendencies do not differ according to consumers' prior experience.Practical implicationsThis study provides insightful information for e-retailers to be mindful of global consumer characteristics. Accordingly, cultural consumption patterns can be used as the basis for market segmentation. In addition, understanding global consumer characteristics and their cultural product- and culture-specific effects on consumption will help cultural industry players in their segmentation and targeting decisions.Originality/valueNotwithstanding the rich body of literature on cultural consumption, this study provides consumer-level comparative empirical research from a marketing perspective. Essentially, the study is novel as it reveals the consumer characteristics that affect cultural consumption tendencies.
Joint viscoacoustic waveform inversion with the separated upgoing and downgoing wavefields in zero‐offset vertical seismic profile data
Authors: Jin Chao , Cao Danping , Zhou Bing , Li Yue , Wang Yuxi 
Published: October 2022

AbstractThe attenuation of seismic waves propagating in reservoirs can be obtained accurately from the data analysis of vertical seismic profile in terms of the quality‐factor Q. The common methods usually use the downgoing wavefields in vertical seismic profile data. However, the downgoing wavefields consist of more than 90% energy of the spectrum of the vertical seismic profile data, making it difficult to estimate the viscoacoustic parameters accurately. Thus, a joint viscoacoustic waveform inversion of velocity and quality‐factor is proposed based on the multi‐objective functions and analysis of the difference between the results inverted from the separated upgoing and downgoing wavefields. A simple separating step is accomplished by the reflectivity method to obtain the individual wavefields in vertical seismic profile data, and then a joint inversion is carried out to make full use of the information of the individual wavefields and improve the convergence of viscoacoustic full‐waveform inversion. The sensitivity analysis of the different wavefields to the velocity and quality‐factor shows that the upgoing and downgoing wavefields contribute differently to the viscoacoustic parameters. A numerical example validates our method can improve the accuracy of viscoacoustic parameters compared with the direct inversion using full wavefield and the separate inversion using upgoing or downgoing wavefield. The application on real field data indicates our method can recover a reliable viscoacoustic model, which helps reservoir appraisal.
Threat or corrective to democracy? The relationship between populism and different models of democracy
Authors: RUTH‐LOVELL SASKIA PAULINE , GRAHN SANDRA 
Published: October 2022

AbstractThe phenomenon of populism and its relationship with modern democracy has gained considerable attention in recent years. This article aims at advancing our understanding of how populism affects different models of democracy and tests the proposed arguments empirically. Building on a large scholarly literature on populism and democracy, we take stock of existing arguments and theorize which democratic models may be affected by populism in a positive or negative way. Moreover, we move beyond the normative debate and analyse the effect of populism in power on different models of democracy empirically. We do so by merging data on populist governments in Europe and Latin America from 1995 until today with the Varieties of Democracy dataset, which enables us to capture the relationship between populism and different democratic models in these regions. Despite mixed‐theoretical expectations, our results suggest a rather negative impact of populism on the electoral, liberal and deliberative models of democracy.
Archaeological surveys of a canyon and floodplain in the Tanūf District, North‐Central Oman: Optimised methodology and applications
Authors: Kuronuma Taichi , Miki Takehiro , Kondo Yasuhisa 
Published: October 2022

AbstractThe highly‐elevated and rugged topography of the Al‐Ḥajar Mountains in Northern Oman requires a topographically‐optimised survey methodology. To reconstruct the archaeological landscapes in the southern piedmont area of the Tanūf District, we applied a combined ground survey and satellite imagery analysis. In the narrow canyon, we travelled towards visible caves on the cliffs and cairns on the ridges and recorded all encountered sites on the way. In the open floodplain and surrounding hills, we visited all visible features after scanning them from higher viewpoints. We utilised satellite imagery to complement inaccessible sites. Accordingly, we identified 23 sites from the Early Bronze Age to the Early Islamic period through ground surveys, and an additional nine sites through satellite imagery analysis. In our qualitative evaluation, this combined method was effective enough to reconstruct the archaeological landscapes of the survey area.
Impact of low‐dose quetiapine‐use on glycosylated hemoglobin, triglyceride and cholesterol levels
Authors: Højlund Mikkel , Støvring Henrik , Andersen Kjeld , Correll Christoph U. , Hallas Jesper 
Published: October 2022

AbstractObjectiveQuetiapine use at standard doses has been associated with hyperglycemia and dyslipidemia. However, whether even frequently prescribed low‐dose quetiapine results in significant metabolic disturbances remains unclear. Thus, this study aimed to investigate the association between off‐label, low‐dose quetiapine and changes in glycosylated hemoglobin (HbA1c) levels/lipid parameters.MethodsWe identified new users of low‐dose quetiapine (≤50 mg tablets) in Denmark 2008–2018 with measurements of HbA1c, total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), or fasting triglycerides (fTG) within 365 days before and after quetiapine initiation. Mixed‐effects linear regression models were used to estimate coefficients (β) with 95% confidence intervals (95%CIs) for change in cardiometabolic parameters after quetiapine initiation. Inverse probability weighting was used to mitigate selection bias. Higher doses of quetiapine (>50 mg) were included in sensitivity analyses.ResultsAmong 106,711 eligible new low‐dose quetiapine users (median age = 45 years, females = 55%), low‐dose quetiapine initiation was associated with increased fTG (β = 1.049[95%CI:1.027–1.072]) and decreased HDL‐C (β = 0.982[0.978–0.986]). Although HbA1c did not change significantly and TC and LDL‐C even decreased considering all subjects, all three metabolic parameters increased significantly among individuals with normal pre‐quetiapine initiation levels. The adverse metabolic effect of quetiapine on HbA1c, TC, LDL‐C, and HDL‐C was dose‐dependent, which was not the case for fTG.ConclusionsLow‐dose quetiapine was associated with a significant increase in fTG and decreases in HDL‐C in all subjects, as well as with significant increases in HbA1c, TC, and LDL‐C among those with normal baseline values. The risk of metabolic worsening with quetiapine was dose‐dependent, except for fTG.
Keeping it in the family
Authors: SCHERZ CHINA , BURRAWAY JOSHUA 
Published: October 2022

ABSTRACTOpioid agonist medications, such as the buprenorphine‐based Suboxone, are becoming increasingly important tools for caring for people with opioid use disorders. Yet, whether at the level of the family, the clinic, or pharmaceutical companies, the circulation of Suboxone can involve forms of concealment, secrecy, and deceit, even as it is used to provide a vital form of care. In exploring the moral economies that shape the licit and illicit circulation of Suboxone in southwest Virginia, we aim to unpack the logics of obligation, care, and secrecy that emerge within a family network caught in a set of sociopolitical, economic, and therapeutic conditions. In exploring how Suboxone circulates at these different scales—in families, in clinics, and in the global pharmaceutical economy—this article shows how secrets lubricate the social, economic, and moral mechanisms through which relationships are sustained and substances circulate. [moral economy,secrecy,substance use,care,rural United States]
Fertilization and overseeding legumes on native grasslands leads to a hardly reversible degraded state
Authors: Pañella Pedro G. , Guido Anaclara , Jaurena Martín , Cardozo Gerónimo , Lezama Felipe 
Published: October 2022

AbstractAimsDiverse practices related to livestock intensification often have a deep impact on grassland diversity. Moreover, alternative degraded states that are hardly reversible can be observed, resulting in low‐diversity communities, dominated by invasive alien species. Therefore, the need arises to understand above‐ground vegetation dynamics in these communities, and the potential of the seed bank to revert this degradation. In this study, we evaluated the impact of overseeding alien legumes coupled with phosphorus fertilization on native grasslands, in terms of above‐ground vegetation composition and soil seed bank.MethodsA long‐term experiment (23 years) was performed in eastern Uruguay with three treatments: (1) native grasslands and native grasslands overseeded with alien legumes and fertilized at a (2) moderate or (3) high phosphorus dosage. Vegetation surveys were done in 2009 and 2019 to evaluate changes, and the seed bank was sampled in 2019.ResultsNative grasslands had higher total richness, native species richness and abundance in both years, as well as a higher species turnover in both temporal and spatial dimensions. The dominant species in overseeded treatments was the invasive alien grass Cynodon dactylon. The seed bank was similar between treatments in terms of seed density and richness, but differed in composition, with a higher abundance of alien species in the overseeded grassland. Seed banks showed low similarity with the above‐ground vegetation.ConclusionsThe overseeded grassland appears to be in a degraded state of low species diversity, with low turnover and invaded by alien species. The seeds in the soil appear to be insufficient to revert this condition and might be a hindrance for restoration due to the high abundance of alien species. Grasslands that have been degraded by long periods of fertilization and overseeding legumes present a great challenge for ecological restoration, since invasive alien species should be controlled before native species are reintroduced.
Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark
Authors: Andersen Charlotte U. , Ahmed Hafsa , Rædkjær Mathias , Hasselstrøm Jørgen B. , Larsen Maiken K. 
Published: October 2022

AbstractInformation regarding deaths caused by poisoning or adverse effects of medication in Danish persons not using illicit narcotic drugs (PNUIDs) is sparse. To characterize aetiology, demographics, and death scene, we reviewed all legal autopsies performed at Aarhus University from 2017 to 2019 and isolated 96 deaths caused by medications in PNUIDs. Suicides caused by medication overdose accounted for 38%. Opioids and psychotropic medications were the main cause of death in 48% and 35% of the 96 cases, respectively. Morphine, tramadol, and quetiapine were the most commonly involved individual medications. A single medication caused death in 50% of cases, and multiple substances were involved in 50%. The median total number [interquartile range] of detected medications was 5 [4–6], with a higher number in females (5 [4–7]) than males (4 [2–5]), p = 0.009. Median age was 51 [42.5–61.5] years, and 57% were female. Scene of death most frequently involved a body on a bed or couch in the decedent's own home (72%). In conclusion, opioids and psychotropic medications dominated by morphine, tramadol and quetiapine most frequently caused medication‐related deaths in PNUIDs. Monitoring this type of death may yield important knowledge to direct prophylactic initiatives regarding medication use and prescription.
A large Canadian database for macroeconomic analysis
Authors: Fortin‐Gagnon Olivier , Leroux Maxime , Stevanovic Dalibor , Surprenant Stéphane 
Published: October 2022

AbstractThis paper provides a large‐scale Canadian macroeconomic database and shows its usefulness for empirical macroeconomic analysis. The data set contains hundreds of Canadian and provincial economic indicators. It is designed to be updated regularly and real‐time vintages are publicly available. It relieves users to deal with data changes and methodological revisions. We show four useful features of this data set for macroeconomic research. First, the factor structure explains a sizeable part of the variation of the data set and appears as an appropriate means of dimension reduction. Second, the data set is useful to capture turning points of the Canadian business cycle. Third, it has substantial predictive power when forecasting key macroeconomic indicators. Fourth, the richness of the panel is used to study the effectiveness of monetary policy across regions and sectors.
Effects on print quality of varying acrylic binder types in water‐based flexographic ink formulations
Authors: Sonmez Sinan , Alsaid Dania , Pekarovicova Alexandra , Fleming Paul D. , Stoops Matthew T. 
Published: October 2022

AbstractThe ink industry is one of the world's largest markets due to the increasing demand for printing inks for the packaging industry. Flexography printing is a well‐known promising technology for large‐area printing due to its high printing speed and roll‐to‐roll capability to print economically on a variety of surfaces and is used in nearly in all areas of packaging printing. Water‐based inks are considered non‐toxic, odourless, and more environmentally friendly options compared to solvent‐based inks. Therefore, in this article, the goal was to develop new water‐based ink formulation with different acrylic binders for flexographic printing on commercial solid bleached sulphate (SBS) board. Five inks were formulated with four different acrylic binders and compared to a commercially available ink to study their performance. The developed inks were investigated with regard to their print qualities and print characteristics. It was found that the binder type influenced some print quality while the effect was not significant for others. Using flexography printed cyan inks, the ink formulated with the highest molecular weight had the lowest print density and the largest tonal value increase (TVI) observed between 40 and 60 tone values. The same ink had the largest mottle values and variation in topography. For values of print contrast and delta gloss at 75°, although differences were observed between average values, data had inconclusive variation and spread around averages, where no conclusive trends or effects of acrylic binder type on these response factors were observed. Print chroma and dot roundness results were equally close for all printed samples.
The association between offspring birthweight and future risk of maternal diabetes: A population‐based study
Authors: Nham Tina , Read Stephanie H. , Giannakeas Vasily , Berger Howard , Feig Denice S. , Fleming Karen , Ray Joel G. , Rosella Laura , Shah Baiju R. , Lipscombe Lorraine L. 
Published: October 2022

AbstractAimsAs an indicator of maternal cardiometabolic health, newborn birthweight may be an important predictor of maternal type 2 diabetes mellitus (diabetes). We evaluated the relation between offspring birthweight and onset of maternal diabetes after pregnancy.MethodsThis retrospective cohort study used linked population‐based health databases from Ontario, Canada. We included women aged 16–50 years without pre‐pregnancy diabetes, and who had a live birth between 2006 and 2014. We used Cox proportional hazard regression to evaluate the association between age‐ and sex‐standardized offspring birthweight percentile categories and incident maternal diabetes, while adjusting for maternal age, parity, year, ethnicity, gestational diabetes (GDM) and hypertensive disorders of pregnancy (HDP). Results were further stratified by the presence of GDM in the index pregnancy.ResultsOf 893,777 eligible participants, 14,329 (1.6%) women were diagnosed with diabetes over a median (IQR) of 4.4 (1.5–7.4) years of follow‐up. There was a continuous positive relation between newborn birthweight above the 75th percentile and maternal diabetes. Relative to a birthweight between the 50th and 74.9th percentiles, women whose newborn had a birthweight between the 97th and 100th percentiles had an adjusted hazards ratio (aHR) of diabetes of 2.30 (95% CI 2.16–2.46), including an aHR of 2.01 (95% CI 1.83–2.21) among those with GDM, and 2.59 (2.36–2.84) in those without GDM.ConclusionsA higher offspring birthweight signals an increased risk of maternal diabetes, offering another potentially useful way to identify women especially predisposed to diabetes.
Catastrophic fracture of the middle phalanx following intra‐articular ethanol injection for facilitated proximal interphalangeal joint ankylosis
Authors: Arndt Stefanie , Katzman Scott A. , LaPorte Alexandra D. , Spriet Mathieu , Maglaty Marisa A. , Murphy Brian G. , Galuppo Larry D. 
Published: October 2022

SummaryFacilitated ankylosis using intra‐articular ethanol has been reported as a viable alternative to proximal interphalangeal (PIP) arthrodesis for owners with financial constraints or reservations regarding the invasiveness of surgical arthrodesis. An 18‐year‐old gelding presented for a left front leg lameness (Grade 4/5 on the AAEP scale) localised to the pastern region. Radiographs revealed severe osteoarthritis of the proximal interphalangeal joint (PIJ). Facilitated ankylosis of the PIJ with 95% alcohol was elected. The horse presented 6 weeks later with a significant worsening of the lameness, swelling of the pastern region and was noticed with the toe elevated off the ground when transiently weight bearing. Radiographs revealed a comminuted fracture of the middle phalanx. The horse was humanely euthanised. Necropsy revealed a severe chronic closed comminuted fracture of the middle phalanx with partially devitalised bone. Potential aetiologies are a decreased bone quality prior to alcohol injection, or that the desensitisation due to the alcohol injection could have resulted in an overuse by the horse or a traumatic accident. While previously unreported, veterinarians should educate owners that catastrophic fracture is an unlikely but possible complication following intra‐articular ethyl alcohol injection.
Who uses robo‐advising and how?
Authors: Baulkaran Vishaal , Jain Pawan 
Published: October 2022

AbstractUsing propriety data from a large Indian robo‐advisory firm, we show that users of robo‐advisory services are relatively young, predominantly male, married, small investors, and professionals. We show that the majority of small retail investors utilize a systematic investment plan (SIP). Additionally, we document that there are differences in demographic characteristics, occupation, and geographic location of investors in utilizing SIP versus one‐time lump sum investments. Furthermore, we find that daily user account creation increases during periods of high market volatility.