bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-cultural Adaptation and Validation of Hindi Version of Roland Morris Disability Questionnaire for Chronic Low Back Pain in Indian Population
Authors: Mohan Anjali , Sharma Rajni , Ghai Babita , Kumar Vishal , Makkar Jeetinder K. , Jain Aditi 
Published: September 2022

Study Design.
A cross-cultural adaptation, validation, and psychometric analysis.

Objective.
The main aim was to assess the validity and reliability of the Hindi version of the Roland Morris Disability Questionnaire (Hi-RMDQ) for chronic low back pain.

Summary of Background Data.
Roland Morris Disability Questionnaire is a standardized, self-administered tool for disability assessment in patients with chronic low back pain. However, its Hindi version has not been validated.

Materials and Methods.
Cognitive debriefing was carried out with 10 patients to ensure the comprehensibility of the Hi-RMDQ. Following this, 120 patients were asked to complete the finalized questionnaire along with the modified Oswestry Disability Index Questionnaire, Quebec Back Pain Disability Score, and the Verbal Numeric Rating Scale. The patients were then asked to again fill out the finalized questionnaire after 72 hours. The internal consistency and retest reliability of the Hindi translated version of the questionnaire was tested. Its correlation with the other scores was also analyzed.

Results.
The translated questionnaire showed excellent internal consistency (Cronbach α=0.989) and excellent retest reliability (intraclass correlation coefficient=0.978). There was a positive and statistically significant association between the Hi-RMDQ, modified Oswestry Disability Index Questionnaire (r=0.807; P<0.01), Quebec Back Pain Disability Score (r=0.839; P<0.01), and Verbal Numeric Rating Scale (r=0.713; P<0.01).

Conclusion.
The Hi-RMDQ version is an easy-to-use, acceptable, reliable, and valid tool to measure disability in the Indian population with nonspecific back pain with or without leg pain.

Level of Evidence.
3.
Reconstructive Surgery in a Patient with High Radial Nerve Palsy Using the WALANT Technique
Authors: Fahandezh-Saddi Díaz Homid , Bebea Zamorano Fátima , Ruiz Zafra Jorge Enrique , Ríos Luna Antonio , Cantero Yubero María Elena , Lalonde Donald H. 
Published: September 2022

Summary:
Tendon transfers can be tied too tight or too loose. Both impede good function after surgery. Performing tendon transfers without sedation and pain during the surgery and then watching the patient move the transfer have helped us adjust the tension more accurately. This method can be applied to complex transfers such as radial nerve palsy triple tendon transfers. We describe the technique and results of a triple tendon transfer using wide-awake local anesthesia no tourniquet in a patient with a high radial nerve palsy. This was a complex case of reconstruction after five operations at the level of the humerus. This left him with a pseudoarthrosis of the humerus and a complete radial nerve palsy. We performed tendon transfers of pronator teres to extensor carpi radialis brevis, flexor carpi ulnaris to extensor digitorum communis, and palmaris longus to extensor pollicis longus tendons. Eighteen months after the triple tendon transfer surgery for the radial nerve palsy, the patient has good extension of the fingers, wrist, and thumb. He can open and close the hand properly. He has excellent function and mobility allowing him to perform most activities in a manner that is practically normal. Wide-awake local anesthesia no tourniquet can be used safely and successfully in complex cases requiring triple radial nerve tendon transfers of pronator teres to extensor carpi radialis brevis, flexor carpi ulnaris to extensor digitorum communis, and palmaris longus to extensor pollicis longus tendons.
Investigating Health Disparities Associated With Multisystem Inflammatory Syndrome in Children After SARS-CoV-2 Infection
Authors: Zambrano Laura D. , Ly Kathleen N. , Link-Gelles Ruth , Newhams Margaret M. , Akande Manzilat , Wu Michael J. , Feldstein Leora R. , Tarquinio Keiko M. , Sahni Leila C. , Riggs Becky J. , Singh Aalok R. , Fitzgerald Julie C. , Schuster Jennifer E. , Giuliano John S. , Englund Janet A. , Hume Janet R. , Hall Mark W. , Osborne Christina M. , Doymaz Sule , Rowan Courtney M. , Babbitt Christopher J. , Clouser Katharine N. , Horwitz Steven M. , Chou Janet , Patel Manish M. , Hobbs Charlotte , Randolph Adrienne G. , Campbell Angela P. ,   for the Overcoming COVID-19 Investigators
Published: September 2022

Background:
Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related complication that has disproportionately affected racial/ethnic minority children. We conducted a pilot study to investigate risk factors for MIS-C aiming to understand MIS-C disparities.

Methods:
This case-control study included MIS-C cases and SARS-CoV-2-positive outpatient controls less than 18 years old frequency-matched 4:1 to cases by age group and site. Patients hospitalized with MIS-C were admitted between March 16 and October 2, 2020, across 17 pediatric hospitals. We evaluated race, ethnicity, social vulnerability index (SVI), insurance status, weight-for-age and underlying medical conditions as risk factors using mixed effects multivariable logistic regression.

Results:
We compared 241 MIS-C cases with 817 outpatient SARS-CoV-2-positive at-risk controls. Cases and controls had similar sex, age and U.S. census region distribution. MIS-C patients were more frequently previously healthy, non-Hispanic Black, residing in higher SVI areas, and in the 95th percentile or higher for weight-for-age. In the multivariable analysis, the likelihood of MIS-C was higher among non-Hispanic Black children [adjusted odds ratio (aOR): 2.07; 95% CI: 1.23–3.48]. Additionally, SVI in the 2nd and 3rd tertiles (aOR: 1.88; 95% CI: 1.18–2.97 and aOR: 2.03; 95% CI: 1.19–3.47, respectively) were independent factors along with being previously healthy (aOR: 1.64; 95% CI: 1.18–2.28).

Conclusions:
In this study, non-Hispanic Black children were more likely to develop MIS-C after adjustment for sociodemographic factors, underlying medical conditions, and weight-for-age. Investigation of the potential contribution of immunologic, environmental, and other factors is warranted.
High Rates of Viral Suppression and Care Retention Among Youth Born Outside of the United States with Perinatally Acquired HIV
Authors: Desai Neerav , Jenkins Cathy A. , Zanoni Brian , Nmoh Ashley , Patel Nehali , Shepherd Bryan E. , Hussen Sophia , Doraivelu Kamini , Pierce Leslie , Carlucci James G , Ahonkhai Aima A. 
Published: September 2022

Background:
Youth born outside of the US with perinatally acquired HIV infection (YBoUS-PHIV) account for most children living with HIV in the US, but there are few data characterizing their care outcomes.

Methods:
We conducted a retrospective study of YBoUS-PHIV receiving care across 3 HIV clinics in the Southeastern US between October 2018 and 2019. Primary outcomes were retention in care and viral suppression defined as (1) proportion of suppressed viral loads (VLs) and (2) having all VLs suppressed (definition 1 presented in the abstract). Primary predictors were age, adoption and disclosure status (full, partial and none/unknown). Multivariable logistic regression and χ2 tests were used to test for associations with care outcomes. Analysis of disclosure status was restricted to youth greater than or equal to 12 years.

Results:
The cohort included 111 YBoUS-PHIV. Median age was 14 years (interquartile range, 12–18), 59% were female, and 79% were international adoptees. Overall, 84% of patients were retained in care, and 88% were virally suppressed at each VL measurement. Adopted youth were more likely to be virally suppressed than nonadopted youth [odds ratio (OR), 7.08; P < 0.01] although the association was not statistically significant in adjusted analysis (adjusted OR, 4.26; P = 0.07). Neither age nor adoption status was significantly associated with retention. Among 89 patients greater than or equal to 12 years, 74% were fully disclosed of their HIV status, 12% were partially disclosed, and 13% had not started the disclosure process. There was no significant difference in retention or viral suppression by disclosure status.

Conclusions:
YBoUS-PHIV achieved high rates of retention and viral suppression. Adopted youth may be more likely to achieve viral suppression which may reflect the need for tailored interventions for nonadopted youth.
Infection control in cystic fibrosis: evolving perspectives and challenges
Authors: Jones Andrew M. 
Published: September 2022

Purpose of review
This article reviews the impact of some of the most recent changes in clinical care management in cystic fibrosis on infection prevention practice and advice for people with cystic fibrosis.

Recent findings
People with cystic fibrosis (CF) consistently highlight infection control as one of their major concerns. Infection prevention guidance and practice has facilitated successful decreases in rates of many transmissible CF pathogens. The coronavirus disease 2019 pandemic highlighted the clinical significance of respiratory viral infections and has accelerated the implementation of remote monitoring and telemedicine consultations as standard practice in CF. The continued improvement in health of the CF population is being further augmented by the introduction of new therapies, in particular cystic fibrosis transmembrane conductance regulator modulators. Infection prevention will remain pertinent to CF care, but these recent changes in clinical practice will have ongoing implications for infection prevention guidance in CF.

Summary
Recent changes in CF clinical care have implications that will lead to further evolution of infection control practice and advice.
Impact of coronavirus disease 2019 on food security in early childhood
Authors: He Yuan 
Published: September 2022

Purpose of review
To summarize the impact of the COVID-19 pandemic on food insecurity during early childhood, with a focus on challenges and strategies to improve access to and consumption of nutritious food in early childcare and education settings.

Recent findings
The COVID-19 pandemic exacerbated existing gaps and inequities in the early childcare and education system, resulting in closures and decreased access to healthy foods that disproportionately impacted black, indigenous, and people of color, as well as rural and low-income communities.

Summary
Closures and changes in operational capacity not only stressed the early childcare and education system and its workforce but also contributed to financial strain and food insecurity among families with young children. Increased public investment and cross-sector partnerships can support and strengthen both early childcare and education and food systems, increasing equitable access to quality care and reducing food insecurity in early childhood.
Social support and transplantation
Authors: Bruschwein Heather , Chen Gloria , Yost Joanna 
Published: September 2022

Purpose of review
Social support has many benefits for patients undergoing organ transplantation, though inclusion of it as criteria for transplant listing has been debated. This review highlights recent developments in the research regarding social support and organ transplantation, including the impact of social support on transplantation and caregivers, interventions, COVID-19, and ethical perspectives.

Recent findings
Social support and perceived social support have benefits for transplant patients, including increased quality of life and adherence. The providers of social support may also be impacted and the impact may vary based on patient and caregiver characteristics, including organ group and caregiver ethnicity. Debates regarding COVID-19 vaccine requirements for caregivers and ethical concerns about the inclusion of social support as criteria for transplant listing are also explored.

Summary
Transplant patients benefit from social support, though additional research is needed on the impact of social support on transplant outcomes and the utility of the use of social support as criteria for transplant listing. There is also a need for more robust research on diverse caregiver populations, including the identification and use of supportive interventions for caregivers.
Extent of lymph node dissection and impact on survival in radical cystectomy for advanced bladder cancer
Authors: Crocerossa Fabio , Autorino Riccardo , Carbonara Umberto , Cantiello Francesco , Damiano Rocco , Mir M. Carmen 
Published: September 2022

Purpose of review
In patients with muscle invasive bladder cancer (MIBC) or unresectable non-MIBC, radical cystectomy is routinely combined with bilateral pelvic lymph node dissection (LND) owing to the oncological benefits found in recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) compared with radical cystectomy alone. However, the optimal anatomic extent of LND is still unclear.

Recent findings
Retrospective studies were consistent in reporting oncological benefits of extended LND over nonextended LND. A recent RCT (the LEA trial) failed to demonstrate any benefit in terms of RFS, CSS and OS of super-extended LND over standard LND. Several confounding factors hindered the interpretation of the results, leaving the question of the right extent for LND still open. Results of a similar study, the SWOG S1011 are, therefore, highly anticipated. This study differed from the LEA study in several aspects but might also turn out to be a negative study.

Summary
There are still no firm data on the oncological benefit brought by more extended LND in patients with MIBC. Survival benefits seem limited, at least in the general population. Other factors could influence the impact of LND on survival, including the administration of adjuvant and neoadjuvant chemotherapies.
Breastfeeding Symptoms with Tongue- and Lip-Tie
Authors: Hill Rebecca R. , Richard Melissa A. , Pados Britt F. 
Published: September 2022

Abstract

Purpose:
The aims of this study were to describe maternal and infant symptoms relative to tongue- and lip-tie severity and describe changes in symptoms and feeding efficiency from pre- to post-frenotomy.

Study Design and Methods:
A one-group pre- and post-intervention study design was used. Data from a dental practice were collected from medical records of infants less than 1 year old who underwent a frenotomy procedure for tongue- and/or lip-tie. Infant and maternal symptoms were compared with severity of tongue- and lip-tie using binary logistic regression. Wilcoxon Signed Rank test compared pain scores and feeding duration pre- and post-frenotomy. Linear regression compared total number of symptoms reported pre-frenotomy with tongue- and lip-tie severity.

Results:

N = 121 dyads were included. More severe classifications of tongue- and lip-tie were significantly associated with certain infant and maternal symptoms pre-frenotomy. Improvements were noted in all reported infant symptoms post-frenotomy. Feeding duration times significantly decreased post-frenotomy.

Clinical Implications:
Infants and mothers experience problematic symptoms with feeding associated with tongue- and lip-tie. Nurses are the primary care providers during postpartum and should be alert to signs and symptoms that may suggest oral restrictions. Early evaluation and involvement of feeding experts may improve the breastfeeding experience of the dyad.
“Exploring the Patient Narrative for Breast Implant Illness: A 10-Year Review of the FDA MAUDE Database”
Authors: Taskindoust Mahsa , Bowman Trevor , Thomas Samantha M. , Levites Heather , Wickenheisser Victoria , Hollenbeck Scott T. 
Published: September 2022

Introduction:
There is growing recognition of a condition known as Breast Implant Illness (BII). Very little information exists about the diagnosis and natural history of BII. To better understand the patient experience, we surveyed the FDA’s MAUDE database for narratives describing symptoms of BII.

Methods:
The Manufacturer and User Facility Device Experience Database (MAUDE) was queried for all reports that included Breast Implant Illness within the patient narrative between 2010 and 2020. A review of narratives was used to identify and summarize 36 symptoms over 9 symptom classes. Event year and reporting year were summarized. Hierarchical clustering analysis using centroid components was conducted on all reported BII symptoms and a dendrogram was created to visualize clustering.

Results:
During the study period from 2010 to 2020, there were 751 captured adverse event reports in the FDA’s MAUDE database that referenced Breast Implant Illness with the first report submission in 2014. Of those reports, 60.6% were for silicone implants and 39.4% were for saline implants. The three most commonly reported symptom categories were neurological (N=544, 72.4%), followed by musculoskeletal (N=418, 55.7%), and dermatological (N=273, 36.4%). The top ten symptoms, irrespective of category, include fatigue/weakness, numbness/tingling, brain fog, depression/anxiety, arthralgia, myalgia, headache, hair loss, gastrointestinal issues, and weight change. A hierarchical clustering analysis demonstrated that symptoms reported by patients clustered into 2 major groups.

Conclusion:
This study demonstrates the utility of public facing databases like MAUDE in understanding the patient experience as it relates to the term Breast Implant Illness.
“Animation Deformity: Evaluating the Role of Morpho-Topological Features in Suggesting Preventive Surgical Procedures.”
Authors: Onishi Fumio , Suzuki Ayumi , Yamakawa Tomomi , Makino Jun , Minabe Toshiharu 
Published: September 2022

Background:
Animation deformity (AD) is an undesirable complication after subpectoral implant reconstruction, and is defined as skin distortion during activation of the pectoralis major muscle. However, detailed anatomical features of deformities have yet to be clarified. This study aimed to elucidate how (morphology) and where (topology) AD occurs in reconstructed breasts, and assess causes and prevention of AD.

Methods:
This study included 100 consecutive patients with breast cancer, who underwent unilateral subpectoral implant reconstruction. AD was evaluated and the patients were grouped according to both, morphological and topological features. Univariate and multivariate analyses were performed to identify independent factors associated with deformities.

Results:
The patients were divided into three groups based on skin distortions with or without implant movement: Group I, 60 patients with upper-medial dimpling; Group II, 41 patients with upper-lateral folding; and Group III, 52 patients with mid-lower lines. Overall, 86 patients (86%) showed one or more types of deformity. Among the patients with AD, 24 (28%) had implant movement. Our study identified axillary dissection as an independent factor for the upper-lateral folding group (OR, 0.30), implant volume for the mid-lower lines group (OR, 1.01), and age for implant movement (OR, 1.06).

Conclusions:
AD was commonly observed in our cohort of patients who underwent subpectoral implant reconstruction, and exhibited three morpho-topological patterns of deformity. The current study demonstrated that the morpho-topological grouping of AD may assist in suggesting possible causes and preventive surgical procedures for these deformities.
Translabial Ultrasound
Authors: Clark Ellen , Wermuth Daniela Escobar , Oliver Janine , Sheridan Alison 
Published: September 2022

Abstract
Midurethral sling (MUS) surgical procedures, in which a polypropylene synthetic mesh graft is transvaginally placed to support the urethra and manage stress urinary incontinence (SUI), is commonly performed (Urology. 2013;82(1):38-41; Radiology. 2018;289(3):728-729). Within 10 years of sling placement, about 1 in 20 women undergo subsequent surgery to revise their mesh, in which the mesh is cut or partially excised (Obstet Gynecol. 2019;133:1099-1108). Translabial ultrasound (TLUS) has been described as a sensitive technique for viewing MUS, although few studies have evaluated its ability to view surgically revised MUS (Radiology. 2018;289(3):721-727). Understanding the anatomy of the MUS is critical to urologists and urogynecologists striving to optimize management of patients presenting with lower urinary tract symptoms and history of MUS. To assess the clinical utility and reliability of TLUS as a diagnostic tool in its detection of MUS discontinuity, we conducted a retrospective analysis on patients who underwent TLUS at a tertiary care center between September 2017 and May 2020 for indication of lower urinary tract symptoms and history of MUS placement. Performance of TLUS was evaluated by comparing findings with operative or clinical records. Among the 81 women included, detection of MUS revision, which was defined as a discontinuity in sling material, had a sensitivity of 84.6% and specificity of 97.1%. Translabial ultrasound is an inexpensive, nonirradiating, and noninvasive modality that is effective at visualizing MUSs. It is a reliable identifier of previous MUS revision, in which it detects a midline discontinuity of the hyperechoic mesh with an average 10 mm gap.
Machine Learning Algorithm Improves the Prediction of Transplant Hepatic Artery Stenosis or Occlusion
Authors: Feldman Keith , Baraboo Justin , Dinakarpandian Deeyendal , Chan Sherwin S. 
Published: September 2022

Abstract
The aim of this study was to determine if machine learning can improve the specificity of detecting transplant hepatic artery pathology over conventional quantitative measures while maintaining a high sensitivity.
This study presents a retrospective review of 129 patients with transplanted hepatic arteries. We illustrate how beyond common clinical metrics such as stenosis and resistive index, a more comprehensive set of waveform data (including flow half-lives and Fourier transformed waveforms) can be integrated into machine learning models to obtain more accurate screening of stenosis and occlusion. We present a novel framework of Extremely Randomized Trees and Shapley values, we allow for explainability at the individual level.
The proposed framework identified cases of clinically significant stenosis and occlusion in hepatic arteries with a state-of-the-art specificity of 65%, while maintaining sensitivity at the current standard of 94%. Moreover, through 3 case studies of correct and mispredictions, we demonstrate examples of how specific features can be elucidated to aid in interpreting driving factors in a prediction.
This work demonstrated that by utilizing a more complete set of waveform data and machine learning methodologies, it is possible to reduce the rate of false-positive results in using ultrasounds to screen for transplant hepatic artery pathology compared with conventional quantitative measures. An advantage of such techniques is explainability measures at the patient level, which allow for increased radiologists' confidence in the predictions.