bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Intracranial Atherosclerosis in Patients With Hypertension With Acute Ischemic Stroke
Authors: Song Jae W. , Xiao Jiayu , Cen Steven Y. , Liu Xiao , Wu Fang , Schlick Konrad , Li Debiao , Yang Qi , Song Shlee S. , Fan Zhaoyang 
Published: May 2022

Background
Studies suggest the presence of sex differences in hypertension prevalence and its associated outcomes in atherosclerosis and stroke. We hypothesized a higher intracranial atherosclerosis burden among men with hypertension and acute ischemic stroke compared with women.

Methods and Results

A multicenter retrospective study was performed from a prospective database identifying patients with hypertension presenting with intracranial atherosclerosis‐related acute ischemic stroke and imaged with intracranial vessel wall magnetic resonance imaging. Proximal and distal plaques on vessel wall magnetic resonance imaging were scored. Negative binomial models assessed the associations between plaque‐count and sex and the interaction between sex and treatment. Covariates were selected by a least absolute shrinkage and selection operator procedure. Sixty‐one patients (n=42 men) were included. There were no significant differences in demographic or cardiovascular risk factors except for smoking history (
P
=0.002). Adjusted total and proximal plaque counts for men were 1.6 (95% CI, 1.2–2.1;
P
<0.01) and 1.4 (95% CI, 1.0–1.9;
P
=0.03) times as high as women, respectively. Female sex was more protective for proximal plaque if treated for hypertension. The risk ratio of men versus women was 1.5 (95% CI, 1.0–2.1) for treated patients. The risk ratio of men versus women was 0.7 (95% CI, 0.4–1.3) for untreated patients. The relative difference between these 2 risk ratios was 2.0 (95% CI, 1.1–3.9), which was statistically significant from the interaction test,
P
=0.04.

Conclusions
Men with hypertension with acute ischemic stroke have significantly higher total and proximal plaque burdens than women. Women with hypertension on anti‐hypertensive medication showed a greater reduction in proximal plaque burden than men. Further confirmation with a longitudinal cohort study is needed and may help evaluate whether different treatment guidelines for managing hypertension by sex can help reduce intracranial atherosclerosis burden and ultimately acute ischemic stroke risk.
The Heterogeneous Impact of Market Size on Innovation: Evidence from French Firm-Level Exports
Authors: Aghion Philippe , Bergeaud Antonin , Lequien Matthieu , Melitz Marc J. 
Published: May 2022

Abstract
We analyze how demand conditions faced by a firm in its export markets affect its innovation decisions. We exploit exogenous firm-level export demand shocks and find that firms respond by patenting more; furthermore, this response is driven by the subset of initially more productive firms. The patent response arises two to five years after the shock, highlighting the time required to innovate. In contrast, the demand shock raises contemporaneous sales and employment for all firms regardless of their productivity. This skewed innovation response to common demand shocks arises naturally from a model of endogenous innovation and competition with firm heterogeneity.
Children’s Sleep and Human Capital Production
Authors: Jagnani Maulik 
Published: May 2022

Abstract
This paper uses exogenous variation in sleep induced by sunset time to present the first human capital estimates of (i) the effects of child sleep from the developing world and (ii) the long-run effects of child sleep in any context. Later sunset reduces children’s sleep: when the sun sets later, children go to bed later but fail to compensate by waking up later. Sleep-deprived children study less and increase nap time and indoor leisure activities. Short-run sleep loss decreases children’s test scores. Chronic sleep deficits translate into fewer years of education and lower primary and middle school completion rates among school-age children.
Reading the Candlesticks: An OK Estimator for Volatility
Authors: Li Jia , Wang Dishen , Zhang Qiushi 
Published: May 2022

Abstract
We propose an Optimal candlesticK (OK) estimator for the spot volatility using high-frequency candlestick observations. Under a standard infill asymptotic setting, we show that the OK estimator is asymptotically unbiased and has minimal asymptotic variance within a class of linear estimators. Its estimation error can be coupled by a Brownian functional, which permits valid inference. Our theoretical and numerical results suggest that the proposed candlestick-based estimator is much more accurate than the conventional spot volatility estimator based on high-frequency returns. An empirical illustration documents the intraday volatility dynamics of various assets during the Fed chairman’s recent congressional testimony.
Who Saved the Parthenon?
Authors: St Clair William 
Published: May 2022

In this magisterial book, William St Clair unfolds the history of the Parthenon throughout the modern era to the present day, with special emphasis on the period before, during, and after the Greek War of Independence of 1821–32. Focusing particularly on the question of who saved the Parthenon from destruction during this conflict, with the help of documents that shed a new light on this enduring question, he explores the contributions made by the Philhellenes, Ancient Athenians, Ottomans and the Great Powers.
Marshalling a vast amount of primary evidence, much of it previously unexamined and published here for the first time, St Clair rigorously explores the multiple ways in which the Parthenon has served both as a cultural icon onto which meanings are projected and as a symbol of particular national, religious and racial identities, as well as how it illuminates larger questions about the uses of built heritage. This book has a companion volume with the classical Parthenon as its main focus, which offers new ways of recovering the monument and its meanings in ancient times.
St Clair builds on the success of his classic text, The Reading Nation in the Romantic Period, to present this rich and authoritative account of the Parthenon’s presentation and reception throughout history. With weighty implications for the present life of the Parthenon, it is itself a monumental contribution to accounts of the Greek Revolution, to classical studies, and to intellectual history.
Sub-Severe and Severe Hail
Authors: Elmore Kimberly L. , Allen John T. , Gerard Alan E. 
Published: May 2022

Abstract
The occurrence and properties of hail smaller than severe thresholds (diameter < 25 mm) are poorly understood. Prior climatological hail studies have predominantly focused on large or severe hail (diameter at least 25 mm or 1 in.). Through use of data from the Meteorological Phenomena Identification Near the Ground project, Storm Data, and the Community Collaborative Rain, Hail and Snow Network the occurrence and characteristics of both severe and sub-severe hail are explored. Spatial distributions of days with the different classes of hail are developed on an annual and seasonal basis for the period 2013–20. Annually, there are several hail-day maxima that do not follow the maxima of severe hail: the peak is broadly centered over Oklahoma (about 28 days yr−1). A secondary maximum exists over the Colorado Front Range (about 26 days yr−1), a third extends across northern Indiana from the southern tip of Lake Michigan (about 24 days yr−1 with hail), and a fourth area is centered over the corners of southwest North Carolina, northwest South Carolina, and the northeast tip of Georgia. Each of these maxima in hail days are driven by sub-severe hail. While similar patterns of severe hail have been previously documented, this is the first clear documentation of sub-severe hail patterns since the early 1990s. Analysis of the hail size distribution suggests that to capture the overall hail risk, each of the datasets provide a complimentary data source.
Identification of miRNA biomarkers for stomach adenocarcinoma
Authors: Qian Hao , Cui Nanxue , Zhou Qiao , Zhang Shihai 
Published: May 2022

AbstractBackgroundStomach adenocarcinoma (STAD) is a common malignant tumor in the world and its prognosis is poor, miRNA plays a role mainly by influencing the expression of mRNAs, and participates in the occurrence and development of tumors. However, reliable miRNA prognostic models for stomach adenocarcinoma remain to be identified.ResultsUsing the data from the Cancer Genome Atlas (TCGA), a prognostic model of stomach adenocarcinoma was established including tumor stage and expression levels of 4 miRNAs (hsa-miR-379-3p, hsa-miR-2681-3p, hsa-miR-6499-5p and hsa-miR-6807-3p). A total of 50 ultimate target genes of these miRNAs were obtained through prediction. Enrichment analysis revealed that target genes were mainly concentrated in neural function and TGF-β and FoxO signaling pathways. Survival analysis showed that three model miRNAs (hsa-miR-379-3p, hsa-miR-2681-3p and hsa-miR-6807-3p) and five final target genes (DLC1,LRFN5,NOVA1,POU3F2andPRICKLE2) were associated with the patient's overall survival outcome.ConclusionsWe used bioinformatics methods to screen new prognostic miRNA markers from TCGA and established a prognostic model of STAD, so as to provide a basis for the diagnosis, prognosis, and treatment of STAD in the future.
renz: An R package for the analysis of enzyme kinetic data
Authors: Aledo Juan Carlos 
Published: May 2022

Abstract
Background
Complex enzymatic models are required for analyzing kinetic data derived under conditions that may not satisfy the assumptions associated with Michaelis–Menten kinetics. To analyze these data, several software packages have been developed. However, the complexity introduced by these programs is often dispensable when analyzing data conforming to the canonical Michaelis–Menten model. In these cases, the sophisticated routines of these packages become inefficient and unnecessarily intricated for the intended purpose, reason for which most users resort to general-purpose graphing programs. However, this approach, in addition of being time-consuming, is prone to human error, and can lead to misleading estimates of kinetic parameters, particularly when unweighted regression analyses of transformed kinetic data are performed.

Results
To fill the existing gap between highly specialized and general-purpose software, we have developed an easy-to-use R package, renz, designed for accurate and efficient estimation of enzyme kinetic parameters. The package provides different methods that can be clustered into four categories, depending on whether they are based on data fitting to a single progress curve (evolution of substrate concentration over time) or, alternatively, based on the dependency of initial rates on substrate concentration (differential rate equation). A second criterion to be considered is whether the experimental data need to be manipulated to obtain linear functions or, alternatively, data are directly fitted using non-linear regression analysis. The current program is a cross-platform, free and open-source software that can be obtained from the CRAN repository. The package is accompanied by five vignettes, which are intended to guide users to choose the appropriate method in each case, as well as providing the basic theoretical foundations of each method. These vignettes use real experimental data to illustrate the use of the package utilities.

Conclusions
renz is a rigorous and yet easy-to-use software devoted to the analysis of kinetic data. This application has been designed to meet the needs of users who are not practicing enzymologists, but who need to accurately estimate the kinetic parameters of enzymes. The current software saves time and minimizes the risk of making mistakes or introducing biases due to uncorrected error propagation effects.
Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis
Authors: Ibeneme Sam Chidi , Uwakwe Victor Chukwuebuka , Myezwa Hellen , Irem Franklin Onyedinma , Ezenwankwo Fortune Elochukwu , Ajidahun Tunde Adedayo , Ezuma Amarachi Destiny , Okonkwo Uchenna Prosper , Fortwengel Gerhard 
Published: May 2022

Abstract
Background
Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: what is the extent to which physical exercise training affected, symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of intervention, usual care, or no treatment controls?

Method
Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2).

Results
Thirteen studies met the inclusion criteria with 779 participants (n = 596 participants at study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18–86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2–3 times/week, at 40–60 min/session, and for between 6-24 weeks, and the risk of bias vary from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD = − 0.74, 95% confidence interval (CI) − 1.01, − 0.48, p ≤ 0.0002; I2 = 47%; 5 studies; 205 participants) unlike PAL (SMD = 0.98, 95% CI − 0.25, 2.17, p = 0.11; I2 = 82%; 2 studies; 62 participants) and social participation (SMD = 0.04, 95% CI − 0.65, 0.73, p = 0.91; I2 = 90%; 6 studies; 373 participants).

Conclusion
Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect PAL and social participation. However, the high heterogeneity in the included studies, implies that adequately powered randomised controlled trials with clinical/methodological similarity are required in future studies.

Trail Registration number

INPLASY202040048.
Acceptance of COVID-19 vaccination and influencing factors among people living with HIV in Guangxi, China: a cross-sectional survey
Authors: Su Jinming , Jia Zhenwei , Wang Xinwei , Qin Fengxiang , Chen Rongfeng , Wu Yuting , Lu Beibei , Lan Chunlin , Qin Tongxue , Liao Yinlu , Shi Minjuan , Liao Yanyan , Pan Peijiang , Ye Li , Jiang Junjun , Liang Hao 
Published: May 2022

Abstract
Background
Vaccination has been proven to be an effective approach against the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to determine the acceptance rate and factors influencing acceptance of COVID-19 vaccination among people living with HIV (PLWH) in Guangxi, China.

Methods
A cross-sectional survey was carried out in five cities in Guangxi, China from May 7 to June 1, 2021. Questionnaires on the acceptance of COVID-19 vaccination and the related factors were conducted among PLWH recruited by simple random sampling. Univariate and multivariate logistic regression analyses were performed to identify factors associated with acceptance of COVID-19 vaccination.

Results
Of all valid respondents (n = 903), 72.9% (n = 658) were willing to receive COVID-19 vaccination. Fear of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was the main reason for being willing to receive vaccination (76.0%), while the main reasons for not willing were the concerns about vaccine safety (54.7%) and the vaccination’s effect on antiretroviral therapy (ART) (50.6%). The most important factors influencing acceptance were the perception that vaccination is unsafe for HIV-infected people (aOR = 0.082, 95% CI = 0.024–0.282) and the poor efficacy in preventing SARS-CoV-2 infection in HIV-infected people (aOR = 0.093, 95% CI = 0.030–0.287). Other factors associated with acceptance included Zhuang ethnicity (aOR = 1.653, 95% CI = 1.109–2.465), highest education level of middle school, high school or above (aOR = 1.747, 95% CI = 1.170–2.608; aOR = 2.492, 95% CI = 1.326–4.682), and the vaccination having little effect on ART efficacy (aOR = 2.889, 95% CI = 1.378–6.059).

Conclusions
Acceptance rate of the COVID-19 vaccination is relatively low among PLWH compared to the general population in China, although some patients refused vaccination due to concerns about vaccine safety and vaccination affecting ART efficacy. More research is needed to investigate the impact of the COVID-19 vaccines on ART efficacy and the effectiveness in preventing SARS-CoV-2 infection among PLWH.
2D-perfusion angiography for intra-procedural endovascular treatment response assessment in chronic mesenteric ischemia: a feasibility study
Authors: Thurner Annette , Augustin Anne Marie , Bley Thorsten Alexander , Kickuth Ralph 
Published: May 2022

Abstract
Background
Endovascular revascularization has become the first-line treatment of chronic mesenteric ischemia (CMI). The qualitative visual analysis of digital subtraction angiography (DSA) is dependent on observer experience and prone to interpretation errors. We evaluate the feasibility of 2D-Perfusion Angiography (2D-PA) for objective, quantitative treatment response assessment in CMI.

Methods
49 revascularizations in 39 patients with imaging based evidence of mesenteric vascular occlusive disease and clinical signs of CMI were included in this retrospective study. To assess perfusion changes by 2D-PA, DSA-series were post-processed using a dedicated, commercially available software. Regions of interest (ROI) were placed in the pre- and post-stenotic artery segment. In aorto-ostial disease, the inflow ROI was positioned at the mesenteric artery orifice. The ratios outflow to inflow ROI for peak density (PD), time to peak and area-under-the-curve (AUC) were computed and compared pre- and post-interventionally. We graded motion artifacts by means of a four-point scale. Feasibility of 2D-PA and changes of flow parameters were evaluated.

Results
Motion artifacts due to a mobile vessel location beneath the diaphragm or within the mesenteric root, branch vessel superimposition and inadequate contrast enhancement at the inflow ROI during manually conducted DSA-series via selective catheters owing to steep vessel angulation, necessitated exclusion of 26 measurements from quantitative flow evaluation. The feasibility rate was 47%. In 23 technically feasible assessments, PDoutflow/PDinflow increased by 65% (p < 0.001) and AUCoutflow/AUCinflow increased by 85% (p < 0.001). The time to peak density values in the outflow ROI accelerated only minimally without reaching statistical significance. Age, BMI, target vessel (celiac trunk, SMA or IMA), stenosis location (ostial or truncal), calcification severity, plaque composition or the presence of a complex stenosis did not reach statistical significance in their distribution among the feasible and non-feasible group (p > 0.05).

Conclusions
Compared to other vascular territories and indications, the feasibility of 2D-PA in mesenteric revascularization for CMI was limited. Unfavorable anatomic conditions contributed to a high rate of inconclusive 2D-PA results.
Enhanced echo intensity of skeletal muscle is associated with poor physical function in hemodialysis patients: a cross-sectional study
Authors: Wu Junzhen , Luo Haiqing , Ren Shunrong , Shen Longxiang , Cheng Dongsheng , Wang Niansong 
Published: May 2022

Abstract
Background
Patients on hemodialysis often suffer from reduced muscle strength and exercise capacity due to the decreased quantity and quality of muscle. Cumulative studies showed ultrasound echo intensity (EI) had great potential in evaluating muscle quality. The objective of this study was to evaluate the relationship between EI of skeletal muscle and physical function of patients on maintenance hemodialysis.

Methods
Cross-sectional area (CSA) and mean EI of the right rectus femoris were measured by ultrasound to evaluate the quantity and quality of the muscle, respectively. Physical function was measured by handgrip strength (HGS), gait speed, sit-to-stand 60 s (STS-60) test, and instrumental activities of daily living (IADL) scale.

Results
A total of 107 patients on hemodialysis were included, with women accounting for 37.3% (n = 40), and a mean age of 53.53 ± 12.52 years. Among the patients on hemodialysis, EI was moderately and negatively correlated with HGS (r =  − 0.467, P < 0.001), gait speed (r =  − 0.285, P = 0.003), and STS-60 (r =  − 0.313, P = 0.001). Multiple regression analyses adjusted for CSA showed that the enhanced EI of patients on hemodialysis remained associated with worse HGS (β =  − 0.207, P = 0.047), lower gait speed (β =  − 0.002, P = 0.001), less STS-60 (β =  − 0.136, P = 0.049), and a higher likelihood of dependency in IADL (Odds Ratio: 1.070, 95% CI: [1.033–1.111], P = 0.001).

Conclusions
In patients on hemodialysis, enhanced EI in the skeletal muscle measured via ultrasound was correlated with poor physical performance. The combined muscle quality and muscle quantity evaluation provide more information for assessing the level of physical function of the patients.