bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Adrenergic Alpha-1 Receptor Antagonists in Older Adults: A Systematic Review and Meta-analysis for the Development of Recommendations to Reduce Potentially Inappropriate Prescribing
Authors: Mansbart Felix , Kienberger Gerda , Sönnichsen Andreas , Mann Eva 
Published: January 2022

Abstract
BackgroundAdrenergic alpha-1 receptor antagonists (alpha-1 antagonists) are frequently used medications in the management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and in the management of therapy-resistant arterial hypertension, two conditions frequently found in older adults. This systematic review aims at presenting a complete overview of evidence over the benefits and risks of alpha-1 antagonist treatment in people ≥ 65 years, and at deriving recommendations for a safe application of alpha-1 antagonists in older adults from the evidence found.MethodsA comprehensive literature search was performed including multiple databases (Medline/Pubmed, Embase, the Cochrane Library) and using the PICOS framework to define search terms. The selection of the studies was done by two independent reviewers in a two-step approach, followed by a systematic data extraction. Quality appraisal was performed for each study included using standardised appraisal tools. The studies retrieved and additional literature were used for the development of recommendations, which were rated for strength and quality according to the GRADE methodology. ResultsFourteen studies were included: 3 meta-analyses, 6 randomised controlled trials and 5 observational trials. Doxazosin in the management of arterial hypertension was associated with a higher risk of cardiovascular disease, particularly heart failure, than chlorthalidone. Regarding treatment of LUTS suggestive of BPH, alpha-1 antagonists appeared to be effective in the relief of urinary symptoms and improvement of quality of life. They seemed to be less effective in preventing disease progression. Analyses of the risk profile indicated an increase in vasodilation related adverse events and sexual adverse events for some agents. One large observational study points at an increased risk of falls and fractures. The effects of long-term treatment remained unclear. All meta-analyses and 5 out of 6 interventional studies were downgraded in the quality appraisal. 4 out of 5 observational studies were of good quality.ConclusionsIt cannot be recommended to use doxazosin as first-line antihypertensive agent neither in older adults nor in younger patients. In the management of BPH alpha-1 antagonists promise to effectively relieve urinary symptoms with uncertainty regarding their efficacy in preventing long-term progression events.
Changes in Effective Optical Zone After Small-Incision Lenticule Extraction in High Myopia
Authors: Sun Lixia , Lin Hui-Ni , Jhanji Vishal , Ng Tsz Kin , Ji Rui-feng , zhang riping 
Published: January 2022

Abstract
Purpose: To evaluate the four measurement approaches on the determination of effective optical zone (EOZ) using Scheimpflug tomography after SMILE surgery in eyes with high myopia.Setting: Corneal refractive surgery conducted in eye hospital in southern ChinaDesign: A retrospective cohort study.Methods: Total 74 subjects were recruited. EOZ was measured at 3 months postoperatively using Vertex-Based total corneal refraction method (EOZV), pupil-based total corneal refraction method (EOZP), 4 mm-Ring-Based total corneal refraction method (EOZ4), and axial curvature difference map (EOZD), and their consistencies were compared. EOZs and planned optical zone (POZ) were compared and analyzed with eccentricity, ablation degree (AD) and total corneal aberrations.Results: Mean AD was -6.87 ± 0.75 D, and eccentricity was 0.30 ± 0.17 mm. At 3 months after surgery, the mean root mean square of ΔHOA, ΔComa, ΔTrefoil and ΔSA were 0.53 ± 0.27 μm, 0.36 ± 0.20 μm, 0.01 ± 0.84 μm, and, 0.16 ± 0.14 μm respectively. EOZV, EOZP, EOZ4 and EOZD were 5.87 ± 0.44 mm, 5.85 ± 0.45 mm, 4.78 ± 0.40 mm, 5.29 ± 0.27 mm respectively, which were significantly smaller than POZ 6.48 ± 0.16 mm. Bland Altman plots showed a good consistency between the four EOZs. The difference between the EOZV and EOZP was 0.02 mm within the range of clinically acceptable difference. In addition, EOZD was positively correlated with AD, and the eccentricity was positively correlated with ΔHOA, ΔComa and ΔSA.Conclusions: All 4 measurement approaches demonstrated the reduction of EOZs compared to POZ. EOZV was the closest to POZ, followed by EOZP. ΔEOZs showed no significant difference with eccentricity, AD and corneal aberrations. Our results are useful for the full characterization of corneal treatment profiles after kerato-refractive surgery.
Assessment of Plant Species Suitability in Green Walls Based on API, Heavy Metal Accumulation, and Particulate Matter Capture Capacity
Authors: Hozhabralsadat Mersedeh Sadat , Heidari Ava , Karimian Zahra , Farzam Mohammad 
Published: January 2022

Abstract
Today, one of the most pressing issues confronting the civilized and modern world is air pollution. Particulate matter (PM) is a well-known pollutant that contributes significantly to urban air pollution and has numerous short- and long-term adverse effects on human health. One method of reducing air pollution is to create green spaces, mainly green walls, as a short-term solution. The current study investigated the ability of nine plant species to reduce traffic-related PM using a green wall system installed along a busy road in Mashhad, Iran. The main aims were (1) estimate the tolerance level of plant species on green walls to air pollution using the Air pollution tolerance index (APTI); (2) assess the PM capture on the leaves of green wall species using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX) analysis and accumulation of heavy metals using Inductively Coupled Plasma (ICP); (3) select the most tolerance species for reducing air pollution using Anticipated Performance Index (API). The plants' APTI values ranged from 5 to 12. The highest APTI value was found in Carpobrotus edulis and Rosmarinus officinalis, while Kochia Prostrata had the lowest. Among the APTI constituents, leaf water content (R2 = 0.29) and ascorbic acid (R2 = 0.33) had a positive effect on APTI. According to SEM analysis, many PM were adsorbed on the adaxial and abaxial leaf surfaces, as well as near the stomata of Lavandula angustifolia, C. edulis, Vinca minor, and Hylotelephium sp. Based on EDX analysis, carbon and oxygen formed the highest amount (more than 60%) of metals detected in the elemental composition of PM deposited on the leaves of all species. The Sedum reflexum had the highest Cr, Fe, Pb, and As accumulation. The concentrations of all heavy metals studied in green wall plants were higher than in the control sample. Furthermore, the C. edulis is the best plant for planting in industrial, urban areas of the city based on APTI, biological, economic, and social characteristics. It concludes that the use of green walls composed primarily of plants with small leaves can significantly adsorb PM and accumulation of heavy metal.
Modulatory Role of Macrophage Migration Inhibitory Factor on Cytokines and Clinical Features of Sarcoidosis
Authors: Elahi Morvarid , Talreja Jaya , Koth Laura L. , Samavati Lobelia 
Published: January 2022

Abstract
Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology with a significant heterogeneity in organ manifestations, severity, and clinical course. Subjects with sarcoidosis share several features such as, non-necrotizing granuloma, hypergammaglobulinemia, increased local and circulating inflammatory cytokines, such as interleukin (IL)-6, IL-18, and interferon gamma (IFN-γ). Macrophage migration inhibitory factor (MIF) is a pluripotent chemokine produced by various cell types. The expression of MIF at sites of inflammation suggests a regulatory role in the function of macrophages. The objective of this study was to investigate the role of MIF in the serum and bronchoalveolar lavage (BAL) fluid of sarcoidosis patients in association with clinical features and other cytokines. Methods: Sera and BALs of sarcoidosis patients (n=55) were collected at the time of diagnosis and patients were followed longitudinally for 3 years. Additionally, fifteen healthy controls participated in the study. The medical records of all patients including, demographics, radiography stages, pulmonary function tests, and organ involvements were recorded. The levels of MIF, IL-18, IL-10, IL-6, IFN-γ and lysozyme in serum and BAL samples were measured by ELISA. Statistical analyses were performed using SPSS software. Results: Serum MIF had a remarkable positive correlation with IL-10 and IFN-γ but had a negative correlation with serum IgG levels. Importantly, longitudinal follow-up showed a positive correlation between MIF and % predicted diffusion capacity (%DLCO) at 3-year. Serum IL-18 had a significant positive correlation with serum lysozyme, but a negative correlation with % predicted total lung capacity at 3-year follow up. We identified two groups of sarcoidosis subjects with distinct clinical and cytokine features. A group with prominent extrapulmonary involvement, and low serum MIF, IL-10 and IFN-γ levels and a group with elevated serum MIF, IL-10 and IFN-γ levels. Moreover, we found a negative correlation between BAL IL-18 and BAL MIF in sarcoidosis subjects.Conclusions: Patients with low serum MIF, IL-10 and IFN-γ levels has severe and mostly extrapulmonary sarcoidosis with elevated lysozyme and IL-18 levels. Our work provides understanding of phenotypic diversity in association with heterogeneity in cytokine landscape in sarcoidosis.
A Risk Signature Established From Three Coagulation-fibrinolysis Genes Predicts Prognosis in Digestive System Pancancer
Authors: Wang Xingyun , Ji Jinli , Jiang Ying , Zhao Yiyang , Song Zheyao , He Zikang , Shen Ping , Wang Huan , Luo Liangyu , Guan Huilin , Cui Rongjun 
Published: January 2022

Abstract
Venous thromboembolism (VTE) is one of the major complications of digestive system cancer, and coagulation-fibrinolysis genes play an important role in VTE. We used univariate Cox analysis, least absolute shrinkage and selection operator (LASSO), and multivariate Cox analysis to construct 3-PCFGs (prognostic coagulation-fibrinolysis genes) model based on six prognostic coagulation-fibrinolysis genes. Gene set enrichment analysis (GSEA) was used to analyze the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of the high- and low-risk groups. In addition, we classified digestive system pancancer patients into three clusters A, B, and C based on 3-PCFGs by K means. High-risk group and cluster C were associated with poor prognosis in digestive system pancancer. The m6A-related genes ALKBH5, FTO, RBM15, YTHDC1, and YTHDC2 (P<0.001) were highly expressed in the high-risk group and cluster C. The risk score was positively correlated with cancer-associated fibroblasts and endothelial cells. Cluster C had the highest immune score and stromal score. The poor prognosis in the high-risk group and cluster C may be affected by m6A epigenetic modification and immune microenvironment components in the digestive system pancancer.
Molecular (ISSR, cp DNA, ITS) and Morphological Study of the Genus Tragopogon L. (Asteraceae)
Authors: Azizi Hejraneh , Sheidai Masoud , Mozaffarian Valiollah , Noormohammadi Zahra 
Published: January 2022

Abstract
Tragopogon L. (Cichorioideae, Lactuceae, Scorzonerinae) is an Old World genus with 150 species, Rechinger in Flora Iranica divided this genus in 13 section and 37 species that 26 species of them are exist in Iran. Safavi et al. divided it into 26 species without sections in flora Iran. Despite the anatomical and molecular studies done around the world, the exact classification of this genus is not clear due to the high number of secret species, hybridization, polyploidy and rapid diversification. The morphology studies of 32 species and Molecular studies (ISSR, ITS, cp DNA) of 22 species of the genus Tragopogon was investigated . The purpose of these studies are classification and determination of interspecific relationship in this genus. Sections of Rubriflori, Sosnowskya, Chromopappus, Majores, Angustissimi, Krascheninnikovia in flora of Iranica are confirmed on the basis of morphometry and molecular data. Section of Profundisulcati in flora Iranica is confirmed on the base of morphometry data. The Species of T. jesdianus, T . porphyrocephalus, T. rezaiyensis and T. Stroterocarpus in the flora of Iranica are not classified in any section which we classified in the Rubriflori section, Cp DNA dendrogram are not useful for classification in this genus and Chloroplast sequences are very similar among Tragopogon species, Therefore, the use of cp DNA markers in the classification of this genus is not recommended.
Full-Order Sliding Mode Bounded Control for Euler-Lagrange Systems with External Disturbances
Authors: Guo Yong , Di Fuqiang , Lin Xiaodong , Wang Wenlin , Wang Changqing 
Published: January 2022

Abstract
This paper researches two finite-time bounded control methods for Euler-Lagrange systems exposed to external disturbances. A novel full-order terminal sliding mode surface that is convenient for solving the input constraints is designed based on the characters of the hyperbolic tangent function. By using the designed full-order terminal sliding mode surface, the finite-time controller with input constraints can deal with external disturbances with the exactly known upper bound. Further, an adaptive finite-time bounded controller is designed to deal with the external disturbances with the upper bound that cannot be accurately known. Finally, the finite-time stability of the system is proved by using Lyapunov theory and numerical simulations.
Two Differentially Methylated Region (DMR) Networks in Nonalcoholic Fatty Liver Disease, Viral Hepatitis, and Hepatocellular Carcinoma
Authors: Kurokawa Suguru , Yoneda Masato , Ogawa Yuji , Honda Yasushi , Kessoku Takaomi , Imajo Kento , Saito Satoru , Nakajima Atsushi , Hotta Kikuko 
Published: January 2022

Abstract
Background

We previously reported that two differentially methylated region (DMR) networks identified by DMR, and co-methylation analyses are strongly correlated with the fibrosis stages of nonalcoholic fatty liver disease (NAFLD). In the current study, we examined these DMR networks in viral hepatitis and hepatocellular carcinoma (HCC).
Methods

We performed co-methylation analysis of DMRs using a normal dataset (GSE48325), two NAFLD datasets (JGAS000059 and GSE31803), and two HCC datasets (GSE89852 and GSE56588).
Results

One DMR network was clearly observed in viral hepatitis and two HCC populations. Methylation levels of genes in this network were higher in viral hepatitis and lower in HCC. Fatty acid binding protein 1 (FABP1), serum/glucocorticoid regulated kinase 2 (SGK2), and hepatocyte nuclear factor 4 α (HNF4A) were potential hub genes in this network. Increased methylation levels of the FABP1 gene deteriorated the protection capacity of hepatocytes from oxidative metabolites in NAFLD and viral hepatitis. The decreased methylation levels of SGK2 facilitated the growth and proliferation of HCC cells. Decreased methylation levels of HNF4A in HCC cells were associated with tumorigenesis. The other DMR network was observed in NAFLD, but not in viral hepatitis or HCC. This second network-included genes involved in transcriptional regulation, cytoskeleton organization, and cellular proliferation, which are specifically related to fibrosis and/or tumorigenesis in NAFLD.
Conclusions

Our results suggest that one DMR network was associated with fibrosis and tumorigenesis in both NAFLD and viral hepatitis, while the other network was specifically associated with NAFLD progression. FABP1, SGK2, and HNF4A could be possible candidate targets for the prevention and treatment of HCC.
A practical water–energy–climate solution for sustainable and resilient coastal cities: smart use of seawater in municipal services
Authors: ZHANG Zi , SATO Yugo , DAI Ji , Chui Ho-kwong , Daigger Glen , Loosdrecht Mark van , Chen Guang-Hao 
Published: January 2022

Abstract
Municipal services for buildings in developed (sub)tropical coastal cities contributed 18% of greenhouse gases (GHGs) in 2020. One mitigatory solution is the direct use of seawater for district cooling and toilet flushing, which has been applied in Hong Kong on various scales and achieved 30% water and energy savings. However, no systematic evaluation and strategy for this solution are available. Herein, we develop a high-resolution quantitative scheme to elaborate the co-benefits and optimal strategies for expanding this use of seawater. We find that in Hong Kong, Jeddah, and Miami, using local seawater at the city-scale would achieve life-cycle GHG mitigation (42%–56%), energy savings (45%–49%), and freshwater savings (11%–43%). High-resolution analysis reveals that population density and district marginal performance are essential to optimize the efficiency of seawater use. Our scheme confirms the utility of seawater for municipal services and is an effective tool for innovative municipal-service enhancement.
Damming Weakens the Groundwater and Surface Water Exchange and Its Nitrate Removal in Semi-arid Prairie Rivers
Authors: Huang Jing , Lu Xixi , Luo Xin , Hu Haizhu , Jiao Jiu Jimmy 
Published: January 2022

Abstract
Surface water (SW)-Groundwater (GW) exchange plays a vital role in a prairie aquatic system and the biogeochemical cycling in such a system. Considering the inadequate understanding of damming on SW-GW exchange, a damming prairie river in Southeast Eurasian steppe was chosen to investigate variations of the SW-GW exchange and its influences on the fate of nitrate (NO3-). Both hydraulic and hydrochemical methods were applied to precisely depict the daily and seasonal exchange processes. The upstream and downstream reaches of the dam were observed to be upwelling and downwelling conditions respectively within a hydrologic year. Results obtained from multiple tracer methods and hydraulic method indicate that damming contributed to transfer the stream from the upwelling to the downwelling condition and weaken the SW-GW exchange in the downstream. The patterns of SW-GW exchange modulated the NO3- uptake or production between the SW and the GW. NO3- was mainly removed in the SW-GW exchange zone (SW-GW EZ) of the upwelling segment, while produced in the downwelling segment. Both the removal and production of NO3- were enhanced during snowmelt period, which might be an active period for the SW-GW exchange and NO3- fate. This study underscores the negative effect of damming on the SW-GW exchange and accompanied NO3- removal in prairie river systems.
Exploring the Impacts of the Beginning of the COVID-19 Pandemic on Critical Care Physicians and the Delivery of Patient Care in Seven Countries: A Qualitative Interview-Based Study
Authors: Leigh Jeanna Parsons , DeGrood Chloe , Dodds Alexandra , Rubulotta Francesca , FitzGerald Emily A. , Mizen Sara J. , Krewulak Karla D. , Moss Stephana J. , Stelfox Henry T. , Fiest Kirsten M. 
Published: January 2022

Abstract
Purpose

To understand critical care physician experiences across multiple countries with the COVID-19 pandemic to inform future pandemic preparedness planning.
Methods

In this qualitative study, 16 critical care physicians (from seven countries) identified in convenience, purposive sampling took part in individual semi-structured interviews from April 7, 2020 to August 27, 2020 that captured the first wave of the pandemic. Open coding was conducted by two researchers who facilitated inductive thematic analysis.
Results

Key themes identified following thematic analysis included: 1) sourcing and implementation of trusted information; 2) health systems-level preparedness with accessible supports; 3) institutional adaptations including changes to patient care; 4) professional safety and occupational wellbeing; 5) triage and restricted visitation policies; and 6) managing personal familial responsibilities.
Conclusion

Perspectives of critical care physicians are important for ongoing pandemic planning and should be included in future pandemic policy development.
Differential Effects of Transgenerational Plasticity on Morphological and Photosynthetic Properties Between an Invasive Plant and Its Congeneric Native One
Authors: Xiao Xiao , He Linxuan , Zhang Xiaomei , Jin Yu , Chen Jinsong 
Published: January 2022

Abstract
Transgenerational plasticity allows offsprings to be more adaptive in the environmental conditions experienced by their parents. It is suggested that differential effects of transgenerational plasticity on growth performance of offspring ramets may help to understand successful invasion of invasive plant with clonal growth comparing with its congeneric native one. A pot experiment using invasive herb Wedelia trilobata and its congeneric native species Wedelia chinensis was conducted to investigate differential effects of high/low light treatment experienced by mother ramets on morphological and photosynthetic properties of offspring ramets subjected to stressful low light treatment. For W. chinensis, stolon length and maximum carboxylation rate (Vmax) in offspring ramets from mother ramets subjected to low light treatment were significantly greater than those in offspring ramets from mother ramets subjected to high light treatment. For W. trilobata, leaf area and potential maximum net photosynthetic rate (Pmax) in offspring ramets from mother ramets subjected to low light treatment were significantly greater than those in offspring ramets from mother ramets subjected to high light treatment. We tentatively concluded that effects of transgenerational plasticity on morphological and photosynthetic properties among clonal plants could be species-specific. In addition, more favorable effect of transgenerational plasticity on growth performance was observed in the invasive plant than in its congeneric native species. It is suggested that transgenerational plasticity may be very important for successful invasion of invasive plant with clonal growth, especially in maternal environmental conditions. So, our experiment provides new insight into invasive mechanism of invasive plants.