bluuebunny/crossref_metadata_2025_split huggingface dataset:
Citizen reflection reduces support for default vaccination appointments. Evidence from G7 countries
Authors: Banerjee Sanchayan , Hunter Andrew , John Peter , Koenig Richard , Lee-Whiting Blake , Loewen Peter , McAndrews John , Nyhan Brendan , Savani Manu 
Published: August 2022

Abstract
Democratic governments vary in the extent to which they encourage citizens to reflect on the policies that they enact. This trade-off is particularly acute for behavioral nudges like setting default choices, which are often not made explicit to citizens. Using data from an online survey experiment administered to 24,303 respondents in the G7, this paper tests the effects of encouraging citizens to reflect on a hypothetical default nudge policy (automatic enrolment for COVID-19 booster appointments) on both vaccination intentions and policy support. Contrary to expectations, individuals report that they would be less likely to get the booster in the default nudge condition compared to a control condition in which citizens would initiate their own booster appointments. At the same time, individuals were more supportive of the default nudge policy than the control condition policy. However, encouraging people to reflect on the nudge eliminates the increase in policy approval it otherwise generates while strengthening the negative effect it has on vaccination intentions. These results suggest that reflection may increase backlash but can better align expressed policy approval with the behavioral effects the nudge generates.
Quality of Life in Patients With Chronic Low Back Pain at Moi Teaching and Referral Hospital, Eldoret
Authors: Wekesa Michael Makali 
Published: August 2022

Abstract
Purpose
To determine the quality of life and the relationship between sociodemographic, psychopathological, and socio-environmental factors and quality of life in patients with chronic low back pain.
Methods
The study used a descriptive cross-sectional design. Data was collected using sociodemographic and WHOQOL-BREF Questionnaires. Three hundred and eighteen patients were consecutively sampled and data analyzed using computer software. Categorical demographic data were analyzed using frequency and percentages, significant findings were further analyzed by multivariate linear regression.Statistical significance was set at a p-value of < 0.05.
Results
Seventy percent of participants were females while thirty percent were males. The mean Quality of life score for the 4 domains was 50.56(SD = 9.55). On a scale of 1–5, the mean score of the Overall Quality of life facet was 2.42 (SD = 0.80) while that of the general health facet was 2.31 (SD = 0.69). The psychological domain had the highest number of patients with poor scores at n = 69. Older age (46–65) was significantly associated with lower mean QOL at 49.4(SD = 9.2) p < 0.001 compared to younger age groups. This age bracket also reported low physical and psychological health domain scores (mean 36.97 and 54.62, p < 0.0016 respectively). Patients with a higher income level reported a higher psychological domain score (mean 56.75, p < 0.0076). A higher level of education was significantly associated with a high mean QOL (p < 0.022).
Conclusion
Patients with chronic low back pain have a reduced quality of life. Older age, low level of income, and low level of education were significantly associated with low quality of life in patients with chronic low back pain. There is a subset of patients with psychological impairment. A multidisciplinary,biopsychosocial approach to the treatment of this condition is recommended.
Computational Systems Biology in Disease Modeling and Control, Review and Perspectives
Authors: Yue Rongting , Dutta Abhishek 
Published: August 2022

Abstract
Omics-based approaches have become increasingly influential in identifying disease mechanismsand drug responses. Considering that diseases and drug responses are co-expressed andregulated in the relevant omics data interactions, the traditional way of grabbing omics datafrom single isolated layers cannot always obtain valuable inference. Also, drugs have adverseeffects that may impair patients, and launching new medicines for diseases is costly. To resolvethe above difficulties, systems biology is applied to predict potential molecular interactions byintegrating omics data from genomic, proteomic, transcriptional, and metabolic layers. Combinedwith known drug reactions, the resulting models improve medicines’ therapeutical performanceby re-purposing the existing drugs and combining drug molecules without off-target effects.Based on the identified computational models, drug administration control laws are designedto balance toxicity and efficacy. This review introduces biomedical applications and analysesof interactions among gene, protein and drug molecules for modeling disease mechanisms anddrug responses. The therapeutical performance can be improved by combining the predictiveand computational models with drug administration designed by control laws. The challengesare also discussed for its clinical uses in this work.
Evaluations of FDA-approved Drugs Targeting 3CLP of SARS-CoV-2 Employing a Repurposing Strategy
Authors: Ahmad Syed Sayeed , Khalid Mohammad 
Published: August 2022

Background:
The SARS-CoV-2 coronavirus (COVID-19) has raised innumerable global
concerns, and few effective treatment strategies have yet been permitted by the FDA to lighten
the disease burden. SARS-CoV-2 3C-like proteinase (3CLP) is a crucial protease and plays a key
role in the viral life cycle, as it controls replication, and thus, it is viewed as a target for drug
design.

Methods:
In this study, we performed structure-based virtual screening of FDA drugs approved
during 2015-2019 (a total of 220 drugs) for interaction with the active site of 3CLP (PDB ID
6LU7) using AutoDock 4.2. We report the top ten drugs that outperform the reported drugs against
3CLP (Elbasvir and Nelfinavir), particularly Cefiderocol, having the highest affinity among the
compounds tested, with a binding energy of -9.97 kcal/mol. H-bond (LYS102:HZ2-ligand: O49),
hydrophobic (ligand-VAL104), and electrostatic (LYS102:NZ-ligand: O50) interactions were observed
in the cefiderocol-3CLP complex. The docked complex was subjected to a 50 ns molecular
dynamics study to check its stability, and stable RMSD and RMSF graphs were observed.

Results:
Accordingly, we suggest cefiderocol might be effective against SARS-CoV-2 and urge
that experimental validation be performed to determine the antiviral efficacy of cefiderocol against
SARS-CoV-2.

Discussion:
Along with these, cefiderocol is effective for treating respiratory tract pathogens and a
wide range of gram-negative bacteria for whom there are limited therapeutic alternatives

Conclusion:
This article aimed to explore the FDA-approved drugs as a repurposing study against
3CLP for COVID-19 management.
Sildenafil Inhibits the Growth and Epithelial-to-mesenchymal Transition
of Cervical Cancer via the TGF-β1/Smad2/3 Pathway
Authors: Ke Xiao-Ping , Liu Ping , Pei Jing-Jing , Li Li , Li Jing-Wei 
Published: August 2022

Aims:
To explore new potential treatment for cervical cancer.

Background:
Cervical cancer is the second most common cancer in women, causing >250,000 deaths worldwide. Patients with cervical cancer are mainly treated with platinum compounds, which often cause severe toxic reactions. Furthermore, the long-term use of platinum compounds can reduce the sensitivity of cancer cells to chemotherapy and increase the drug resistance of cervical cancer. Therefore, exploring new treatment options is meaningful for cervical cancer.
Objective: The present study was to investigate the effect of sildenafil on the growth and epithelial-to-mesenchymal transition (EMT) of cervical cancer.

Objective:
Objective: The present study was to investigate the effect of sildenafil on the growth and epithelial-to-mesenchymal transition (EMT) of cervical cancer.

Methods:
HeLa and SiHa cells were treated with sildenafil for different durations. Cell viability, clonogenicity, wound healing and Transwell assays were performed. The levels of transforming growth factor-β1 (TGF-β1), transforming growth factor-β type I receptor (TβRI), phosphorylated (p-)Smad2 and p-Smad3 in cervical cancer samples were measured. TGF-β1, Smad2 or Smad3 were overexpressed in HeLa cells, and we measured the expression of EMT marker proteins and the changes in cell viability, colony formation, etc. Finally, HeLa cells were used to establish a nude mouse xenograft model with sildenafil treatment. The survival rate of mice and the tumor size were recorded.

Results:
Results: High concentrations of sildenafil (1.0-2.0 μM) reduced cell viability and the number of HeLa and SiHa colonies and the invasion/migration ability of HeLa and SiHa cells in a dose- and time-dependent manner. The expression of TGF-β1, TβRI, p-Smad2 and p-Smad3 was significantly enhanced in cervical cancer samples and cervical cancer cell lines. Sildenafil inhibited the expression of TGF-β1-induced EMT marker proteins (Snail, vimentin, Twist, E-cadherin and N-cadherin) and p-Smad2/3 in HeLa cells. Overexpression of TGF-β1, Smad2 and Smad3 reversed the effect of sildenafil on EMT, viability, colony formation, migration and invasion ability of HeLa cells. In the in vivo study, sildenafil significantly increased mouse survival rates and suppressed xenograft growth.

Conclusion:
Sildenafil inhibits the proliferation, invasion ability and EMT of human cervical cancer cells by regulating the TGF-β1/Smad2/3 pathway.
Characteristic Hallmarks of Aging and the Impact on Carcinogenesis
Authors: Fiore Marco , Terracina Sergio , Ferraguti Giampiero , Petrella Carla , Bruno Sabina Maria , Blaconà Giovanna , Di Certo Maria Grazia , Minni Antonio , Greco Antonio , Musacchio Angela , Ralli Massimo , Tarani Luigi , Ceccanti Mauro , Polimeni Antonella , Triaca Viviana 
Published: August 2022

Abstract:
Evidence shows that there is a synergistic, bidirectional association between cancer and aging with many shared traits. Age itself is a risk factor for the onset of most cancers while evidence suggests that cancer and its treatments might accelerate aging by causing genotoxic and cytotoxic insults. Aging has been associated with a series of alterations that can be linked to cancer: i) genomic instability caused by DNA damage or epigenetic alterations coupled with repair errors, which lead to progressive accumulation of mutations; ii) telomere attrition with possible impairment of telomerase, shelterin complex, or the trimeric complex (Cdc13, Stn1 and Ten1 – CST) activities associated with abnormalities in DNA replication and repair; iii) altered proteostasis especially when leading to an augmented proteasome, chaperon and autophagy-lysosome activity; iv) mitochondrial dysfunction causing oxidative stress; v) cellular senescence; vi) stem cells exhaustion, intercellular altered communication and deregulated nutrient sensing which are associated with microenvironmental modifications which may facilitate the subsequential role of cancer stem cells. Nowadays anti-growth factor agents and epigenetic therapies seem to assume an increasing role to fight aging-related diseases, especially cancer. This report aims to discuss the impact of age on cancer growth.
Enhancing the Cyanide Sensing Performance of the CuBi2O4 Nanoflakes
by Polyaniline
Authors: Pei Lizhai , Zhang Yong , Zhuang Lihong , Cai Zhengyu 
Published: August 2022

Background:
Cyanide (CN-) belongs to dangerous anion pollutants owing to its toxicity at low level. The development of an efficient method for the cyanide detection in aqueous solution is of tremendous importance for protecting the environment and human health. Polyaniline/CuBi2O4 composite modified electrode possesses good electro-catalytic activity towards cyanide.

Objective:
The aim is to synthesize polyaniline/CuBi2O4 nanoflakes by a facile hydrothermal route using the CuBi2O4 nanoflakes and polyaniline as the raw materials, and research the electro-catalytic activity towards cyanide of the composite nanoflakes.

Methods:
Polyaniline/CuBi2O4 nanoflakes were synthesized by a facile hydrothermal route using the CuBi2O4 nanoflakes and polyaniline as the raw materials. The structure, morphology, chemical bonding and electro-catalytic activity towards cyanide of the composite nanoflakes were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and electrochemical measurements.

Results:
The obtained composite nanoflakes are composed of tetragonal CuBi2O4 phase. Amorphous polyaniline nanoscale particles with the size of about 50 nm attach to the surface of the CuBi2O4 nanoflakes. The nanoflakes modified glassy carbon electrodes (GCEs) were used for the determination of cyanide. A pair of quasi-reversible cyclic voltammetry (CV) peaks are located at +0.25 V and +0.33 V, respectively at the polyaniline/CuBi2O4 nanoflakes modified GCE. The linear range and detection limit are 0.01-2 mM, 3.1 μM and 0.001-2 mM, 0.39 μM for CuBi2O4 nanoflakes modified GCE, and polyaniline/CuBi2O4 nanoflakes modified GCE, respectively.

Conclusion:
Polyaniline/CuBi2O4 nanoflakes modified GCE shows good reproducibility and stability for cyanide detection. The electro-catalytic activity towards cyanide of the CuBi2O4 nanoflakes modified GCE can be greatly enhanced by the polyaniline.
Algorithm for numerical calculation of nonlinear lenticular membrane-pneumatic systems by iterative method of parameter increments taking into account the aftereffect of air pressure
Authors: Kim A. Yu. , Amoyan M. F. , Khapilin V. E. 
Published: August 2022

Objective. The purpose of this study is to create a static calculation algorithm to determine the maximum bearing capacity of a lenticular membrane-pneumatic system for covering large spans under the action of external force loads.Method. A numerical study of a large-span membranepneumatic structure was carried out by the step method of incrementing parameters using the finite element method and the Euler-Cauchy numerical procedure of the third order of accuracy at the step.Result. The authors have developed a technique for computer static calculation of geometrically and physically nonlinear lenticular membrane-pneumatic systems of coatings for large span structures by the iterative method of parameter increments with the phased application of the finite element method in the form of the displacement method, the universal equation of gas state and the improved Euler-Cauchy numerical procedure of the third order of accuracy.Conclusion. Ignoring the aftereffect in the calculations means the imbalance of the system due to unbalanced pneumatic forces calculated with an error of 11.2% and affecting, as the calculations showed, in the amount of approximately 7% percent on the increment of excess air pressure in the lens.
Accumulation of irreversible deformation of soils as a result of repeated loading
Authors: Kondrashin K. G. , Petrov R. A. , Raktovich N. A. 
Published: August 2022

Objective. The purpose of the study is to establish the patterns of accumulation of irreversible soil deformations from repeated loading.Method. When loading soils, the balance between external and internal forces is established gradually over a more or less long time. Therefore, with a single application of a cyclic load, such an equilibrium can be achieved only in a relatively long time.Result. An approximate method is proposed for calculating the magnitude of the deformation developed as a result of the action of a cyclic load. The cases are determined when it is necessary to take into account the viscous component of deformation and when the latter can be neglected. It has been established that when determining the deformation of soils that has developed during a single application of such cyclic loads that are characteristic of the process of their compaction by machines, in all cases, except for rolling them with rollers on pneumatic tires, the viscous component of deformation can be ignored.Conclusion. In a relatively short time of the load, the state of equilibrium can be achieved only in the process of soil deformation by repeated loading. With an increase in the number of loading repetitions, the soil gradually hardens, and the deformation decreases. This occurs both due to the irreversible and reversible parts of the deformation. Consequently, the soil deformation modulus increases from cycle to cycle.
Calorimetric stand for research of processes in the refrigeration unit
Authors: Kudrov Yu. V. , Sumzina L. V. , Maksimov A. V. , Filimonov S. L. 
Published: August 2022

Objective. The aim of the work is to develop a calorimetric stand that allows simulating the operation of an energy-efficient two-evaporator refrigeration unit of a household refrigerator or freezer.Method. In the course of the work, a calorimetric setup is described that allows conducting experimental studies to determine the cooling capacity and energy efficiency of a modernized refrigeration unit of a household refrigerator.Result. Currently, new resource-saving circuit solutions for household refrigeration equipment have been developed. The developed solutions make it possible to increase the efficiency of the refrigeration unit, as well as to reduce its energy consumption. Theoretical calculations confirming these indicators have been carried out. To confirm the calculated values, automated experimental studies are required to determine the parameters of the refrigeration unit. The paper proposes a description of an automated calorimetric stand that allows simulating the operation of an energy-efficient dual-evaporator refrigeration unit of a household refrigerator or freezer.Conclusion. The designed calorimetric stand will allow carrying out complex experimental studies to determine the cooling capacity of the modernized refrigeration unit when operating on various refrigerants. The experimental setup also makes it possible to measure the temperature and pressure during the operation of the refrigeration unit, as well as to determine the influence of various factors on its characteristics.
Compuestos fenólicos totales y actividad antioxidante de la fermentación en estado sólido de bagazo de manzana (Malus domestica Borkh., var. panochera)
Authors: Ibarra-Cantún Diego , Ramos-Cassellis María Elena , Sánchez-Arzubide Madai Gizeh , Castelán-Vega Rosalía del Carmen , Marín-Castro Marco Antonio 
Published: August 2022

La agroindustria genera cantidades importantes de residuos lignocelulósicos. Estos son utilizados como sustrato en la producción de hongos del género Pleurotus, que a través de la fermentación en estado sólido (FES) producen metabolitos secundarios. El objetivo de este trabajo fue determinar la cantidad de compuestos fenólicos totales y la actividad antioxidante de extractos de metanol obtenidos de la FES en bagazo de manzana con la cepa Pleurotus ostreatus durante 28 días. La fermentación sólida se realizó en los días 0, 7, 14, 21 y 28 de los extractos de metanol. Posteriormente, se evaluaron el contenido de compuestos fenólicos totales y la actividad antioxidante por los métodos 1,1-difenil-2-picrilhidracilo (DPPH•) y 2,2’-azino-bis (3-etilbenzotiazolina)-6 sulfonato de amonio (ABTS+). Las 45 muestras fueron analizadas a través de un análisis de varianza y prueba de medias de Tukey. Los resultados mostraron la biosíntesis de compuestos fenólicos totales a partir del día 21 de la FES, con una concentración de 0,39 ± 0,07 mg equivalentes de ácido gálico/g sustrato en base seca (mg de EAG/g sustrato bs). La actividad antioxidante en ambos métodos también se manifestó en el día 21 con actividades equivalentes, de 342,10 ± 1,08 mg/mL para DPPH y 323,02 mg/mL en ABTS. En consecuencia, los compuestos fenólicos extraídos de la FES del residuo de manzana con la cepa P. ostreatus pueden considerarse como una alternativa de valorización de un subproducto que actualmente es considerado como un desecho agroindustrial.
HPV Vaccine Communication Competency Scale for Medical Trainees: Interdisciplinary Development Study
Authors: Darville-Sanders Gabrielle , Reinoso Humberto , MacInnes Jann , Corluyan Emilie , Munroe Dominique , Mathis Mary W , Madden Suzie Lamarca , Hamrick Johnathan , Dickerson Lisa , Gaddis Cheryl 
Published: August 2022

Background
Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the United States. High-risk HPV strains are associated with cancer of the cervix, oropharynx, anus, rectum, penis, vagina, and vulva. To combat increasing HPV-related cancers, the 9-valent HPV vaccine Gardasil was developed. Recommendation of the HPV vaccine by a health care provider has been cited as the number one factor affecting vaccine uptake among adolescents and young adults. Physician assistants, nurse practitioners, and pharmacists have been enlisted to bridge the gap.

Objective
The specific aim of this research study was to develop a reliable and valid HPV vaccine communication scale that can be used to measure the competency of primary care providers when recommending the need for vaccination to parents and patients.

Methods
Using a descriptive study, we collected data via a literature review, focus groups, and an expert panel to inform the scale domains and blueprint design. Pretesting (cognitive interviews) was used to inform item revision decisions. An item analysis was also conducted for the responses provided in the cognitive interviews. Item statistics (means and SDs), interitem correlations, and reliability were examined. Data were analyzed using SPSS (IBM Corp) software.

Results
A valid and reliable 42-item HPV vaccine communication competency scale was developed. The scale included 6 domains of interest. Scale items were moderately to strongly correlated with one another, and Cronbach α indicated good internal consistency with each scale. Scale items included were related to provider introduction or rapport (α=.796), patient respect or empathy (α=.737), provider interview or intake (α=.9), patient counseling or education (α=.935), provider communication closure (α=.896), and provider knowledge (α=.824).

Conclusions
Pharmacists, nurse practitioners, and physician assistants should be trained to be competent in HPV vaccine communication and recommendation due to their expanded roles. Interdisciplinary collaboration is important to account for the trainee’s individual differences and ensure the best health care outcomes for patients. A standardized HPV communication scale can be used to ensure effective and consistent recommendation by health care providers, thus affecting immunization rates.