bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and Potential Effectiveness of a Smartphone Zero-Time Exercise Intervention for Promoting Physical Activity and Fitness in Patients With Coronary Heart Disease: A Pilot Randomized Controlled Trial
Authors: Chan Noel P. T. , Lai Agnes Y. K. , Choy Hau K. , Cheung Derek Y. T. , Wan Alice N. T. , Cheng Victor Y. H. , Chan Ka Y. , Lau Yuk K. , Yung Chi Y. , Cheung George O. C. , Lam T. H. 
Published: July 2022

BackgroundZero-time Exercise (ZTEx), a simple strength- and stamina-enhancing physical activity (PA) requiring no extra equipment, can potentially increase PA and fitness. This pilot trial examined the feasibility and potential effectiveness of a smartphone ZTEx intervention to promote PA and fitness in patients with coronary heart disease (CHD).MethodsA parallel-group assessor-blinded pilot randomized controlled trial was conducted on Chinese patients with stable coronary heart disease (CHD) in three cardiology clinics. The experimental group received a 15-min brief individual face-to-face session and a 12-week ZTEx instant messaging with 28 picture e-messages and a smartphone ZTEx application (ZTExApp). The control group received the same duration of individual session and number and format of e-messages, but the content was healthy eating and breathing exercise. The feasibility was assessed based on: attrition rate, usage, response rate and perception of the intervention. The outcome evaluation included primary outcome (PA), fitness, exercise self-efficacy and intention, perceived happiness and health, and quality of life. A linear mixed model was used with intention-to-treat analysis adjusting for sex, age and baseline values. A semi-structured interview was conducted to collect feedback from the experiment group.ResultsOne hundred thirty-nine patients (mean age 59.8 ± 6.6; 71.2% male) were randomized to the experimental group (n = 70) or control group (n = 69), and 80% (56/70) and 82% (57/69) of patients completed the 12-week follow-up assessment, respectively. The attrition rate was 18.7%. The experimental group reported that ZTEx was feasible to integrate PA into their daily life and appreciated the picture e-messages, and 95% of them sent feedback to us, but only 19.6% (13/70) of the participants entered their PA information into the e-diary of the ZTExApp. The experimental group had a significantly greater increase in time spent walking [mean difference (95% CI): 155.3 (10.1, 300.4), P = 0.04, Cohen's d = 0.34] than the control group.ConclusionsThis pilot study showed using a brief ZTEx face-to-face session with picture e-messages empowered patients with CHD to integrate PA into daily life. Future definitive trials with a longer follow-up and a more user-friendly ZTExApp interface are necessary to determine the effectiveness of the smartphone ZTEx intervention in enhancing PA and related outcomes.Trial RegistrationThe research protocol was registered at the Hong Kong University Clinical Trials Registry (HKUCTR) on 22 Jul 2016 (Study identifier: HKUCTR-2165) and was also retrospectively registered at the National Institutes of Health (identifier number: NCT03464331) on 14 March 2018.
Clinical Efficacy and Safety of Surgical Treatments in Patients With Pure Cervical Radiculopathy
Authors: Gao Quan-You , Wei Fei-Long , Zhu Kai-Long , Zhou Cheng-Pei , Zhang Hu , Cui Wen-Xing , Li Tian , Qian Ji-Xian , Hao Ding-Jun 
Published: July 2022

BackgroundTraditionally paired meta-analysis revealed inconsistencies in the safety and effectiveness of surgical interventions. We conducted a network meta-analysis to assess various treatments' clinical efficacy and safety for pure cervical radiculopathy.MethodsThe Embase, PubMed, and Cochrane Library databases were searched for randomized controlled trials (RCTs) comparing different treatment options for patients with pure cervical radiculopathy from inception until October 23, 2021. The primary outcomes were postoperative success rates, postoperative complication rates, and postoperative reoperation rates. The pooled data were subjected to a random-effects consistency model. The protocol was published in PROSPERO (CRD42021284819).ResultsThis study included 23 RCTs (n = 1,844) that evaluated various treatments for patients with pure cervical radiculopathy. There were no statistical differences between treatments in the consistency model in terms of major clinical effectiveness and safety outcomes. Postoperative success rates were higher for anterior cervical foraminotomy (ACF: probability 38%), posterior cervical foraminotomy (PCF: 24%), and anterior cervical discectomy with fusion and additional plating (ACDFP: 21%). Postoperative complication rates ranked from high to low as follows: cervical disc replacement (CDR: probability 32%), physiotherapy (25%), ACF (25%). Autologous bone graft (ABG) had better relief from arm pain (probability 71%) and neck disability (71%). Among the seven surgical interventions with a statistical difference, anterior cervical discectomy with allograft bone graft plus plating (ABGP) had the shortest surgery time.ConclusionsAccording to current results, all surgical interventions can achieve satisfactory results, and there are no statistically significant differences. As a result, based on their strengths and patient-related factors, surgeons can exercise discretion in determining the appropriate surgical intervention for pure cervical radiculopathy.Systematic Review Registration: CRD42021284819.
Online-Offline Teaching for Bio-Pharmaceutical Students During the COVID-19 Pandemic: The Case Study of Advanced Mathematics in Application-Oriented Universities of China
Authors: Peng Weicai , Wang Shuchao 
Published: July 2022

BackgroundWith the development of the COVID-19 pandemic, the importance of online teaching is becoming more and more prominent, especially for the basic advanced mathematics majoring in bio-pharmaceutical in colleges. However, the only online teaching model loses efficiency when facing the undergraduates in application-oriented universities.PurposeHow to improve the teaching quality of advanced mathematics has always been a concern because the mathematical abilities of students in application-oriented universities are not ideal. In this article, we develop a blending online-offline teaching model that combined online teaching and offline outcome-based education (OBE), as an alternative to traditional offline education.MethodologyThe comparative analysis experiment is carried out to the two classes of undergraduates. The control group and the experimental group are, respectively, the 2020 class students and the 2021 class students majoring in bio-pharmaceutical. The experimental group students receive the combined teaching method, while the control group students receive the traditional offline education.Results(1) From the comparative analysis, we can find that the students under the online-offline teaching model are more differentiated than those under the traditional offline education model. (2) The online-offline teaching model equipped with “case study + knowledge point + applications” process has achieved a good teaching effect in the author's university.ConclusionThe proposed teaching model can well stimulate students' interest in advanced mathematics learning and resonate with students through actual cases, thereby arousing students' autonomous learning drive and allowing them to apply what they have learned to professional fields.
Interplanetary Ion Flux Dropouts Across Multiple 3He-Rich Events
Authors: Ho G. C. , Mason G. M. , Allen R. C. , Wimmer-Schweingruber R. F. , Rodríguez-Pacheco J. , Gómez-Herrero R. 
Published: July 2022

Solar Orbiter, a joint ESA/NASA mission, is studying the Sun and inner heliosphere in greater detail than ever before. Launched in February 2020, Solar Orbiter has already completed its first three orbits, reaching perihelia of 0.5 au from the Sun in June 2020, February and August 2021. During the first 2 years in orbit, Solar Orbiter observed multiple 3He-rich Solar Energetic Particle (SEP) events inside 1 au. Even though these events were small, their spectral forms, 3He content, and association with energetic electrons and type III bursts convincingly identifies them as 3He-rich SEP events with properties similar to those previously observed at 1 au, and promising new insights as Solar Orbiter moves much closer to the Sun in 2022. In May 2021, we observed six 3He-rich SEP events in close succession within 48 h when Solar Orbiter was at 0.95 au. These events were likely released from the same active region at the Sun, and the particles arrived at Solar Orbiter in two batches with various abundances and intensities, showing strong anisotropies throughout. Multiple ion flux dropouts were also observed with these six 3He-rich SEP events. The fact that we observed so many ion injections in such a short period of time indicates the 3He enrichment and acceleration mechanism can produce SEP from the same region very efficiently and with varying enrichment levels and intensities. In addition, we report for the first-time dropout features that spanned multiple ion events simultaneously. This implies the field line random walk that we observe at 1 au still maintains magnetic connections to a small region back at the Sun up to the entire duration of these events (∼48 h).
Comparison of perioperative outcomes between robotic-assisted and video-assisted thoracoscopic surgery for mediastinal masses in patients with different body mass index ranges: A population-based study
Authors: Li Rongyang , Ma Zheng , Qu Chenghao , Qiu Jianhao , Wang Kun , Yue Weiming , Tian Hui 
Published: July 2022

BackgroundThe effectiveness of robotic-assisted thoracoscopic surgery (RATS) for mediastinal masses has not been fully evaluated. This study aimed to compare the perioperative outcomes between RATS and video-assisted thoracoscopic surgery (VATS) for mediastinal masses, and then explore which group of people would benefit more from RATS.MethodsThis retrospective study compared the perioperative outcomes of patients with mediastinal masses who underwent RATS and VATS from September 2018 to December 2021. Subgroup analysis were performed according to body mass index (BMI) ranges.ResultsA total of 212 patients with mediastinal masses (106 RATS cases and 106 VATS cases) were included. Compared with the VATS group, the RATS group had a significantly reduced incidence of overall postoperative complications (5.7% vs. 14.2%, p = 0.039), complications of grade II or less (3.8% vs. 12.3%, p = 0.023), and pneumonia (2.8% vs. 9.4%, p = 0.045). Hospitalization costs were significantly higher in the RATS group (¥ 49350.0 vs. ¥ 32551.9, p &lt; 0.001). There was no significant difference in operation duration, intraoperative estimated blood loss, postoperative chest tube drainage volume, NRS pain score, day of chest tube removal, complications of grade III or more, or in-hospital mortality rate (p &gt; 0.05). Subgroup analysis indicated that the incidence of overall postoperative complications (3.1% vs. 15.2%, p = 0.017), complications of grade II or less (1.5% vs. 12.1%, p = 0.033) and postoperative length of stay (4 days vs. 4.5 days, p = 0.046) were significantly reduced in the RATS group for overweight and obese patients (BMI ≥ 24 kg/m2), while these differences became insignificant in the BMI &lt; 24 kg/m2 subgroup.ConclusionRATS could reduce the incidence of postoperative complications, shorten the postoperative length of stay and might be a more cost-effective surgical treatment for overweight and obese patients with mediastinal masses.
Platelet Priming and Activation in Naturally Occurring Thermal Burn Injuries and Wildfire Smoke Exposure Is Associated With Intracardiac Thrombosis and Spontaneous Echocardiographic Contrast in Feline Survivors
Authors: Tan Avalene W. K. , Li Ronald H. L. , Ueda Yu , Stern Joshua A. , Hussain Mehrab , Haginoya Satoshi , Sharpe Ashely N. , Gunther-Harrington Catherine T. , Epstein Steven E. , Nguyen Nghi 
Published: July 2022

Wildfires pose a major health risk for humans, wildlife, and domestic animals. We previously discovered pathophysiologic parallels between domestic cats with naturally occurring smoke inhalation and thermal burn injuries and human beings with similar injuries; these were characterized by transient myocardial thickening, cardiac troponin I elevation and formation of intracardiac thrombosis. While the underlying mechanisms remain unclear, results from murine models suggest that platelet priming and activation may contribute to a global hypercoagulable state and thrombosis. Herein, we evaluated and compared the degree of platelet activation, platelet response to physiologic agonists and levels of platelet-derived microvesicles (PDMV) in 29 cats with naturally occurring wildfire thermal injuries (WF), 21 clinically healthy cats with subclinical hypertrophic cardiomyopathy (HCM) and 11 healthy cats without HCM (CC). We also quantified and compared circulating PDMVs in WF cats to CC cats. In addition, we examined the association between thrombotic events, severity of burn injuries, myocardial changes, and the degree of platelet activation in cats exposed to wildfires. Flow cytometric detection of platelet surface P-selectin expression showed that WF cats had increased platelet response to adenosine diphosphate (ADP) and thrombin compared to the two control groups indicating the presence of primed platelets in circulation. In addition, cats in the WF group had increased circulating levels of PDMV, characterized by increased phosphatidylserine on the external leaflet. Cats in the WF group with documented intracardiac thrombosis had elevated platelet activation and platelet priming in the presence of ADP. While high dose arachidonic acid (AA) mostly resulted in platelet inhibition, persistent response to AA was noted among cats in the WF group with intracardiac thrombosis. Univariate and multiple logistic regression analyses demonstrated that increased platelet response to AA was independently associated with thrombotic events. This is the first study reporting the significant association between platelet priming and intracardiac thrombosis in domestic cats with naturally occurring wildfire-related injuries and smoke inhalation. Further studies are required to delineate additional mechanisms between inflammation and thrombosis, especially regarding platelet primers and the cyclooxygenase pathway.One Sentence SummaryPlatelet activation and shedding of platelet-derived microvesicles due to platelet priming is present following naturally occurring wildfire smoke exposure and thermal burn injuries in a population of domestic cats.
Self-Reported Clinical Practice of Small Animal Cardiopulmonary Resuscitation and Compliance With RECOVER Guidelines Among Veterinarians in Eight Western European Regions
Authors: Hagley Simon P. , Kruppert Anne , Leal Rodolfo Oliveira , Pizarro del Valle José Carlos , Iannucci Claudia , Hennink Imke , Boiron Ludivine , Hoehne Sabrina N. 
Published: July 2022

IntroductionThe objective of this study was to assess whether small animal veterinarians across Western Europe are compliant with the 2012 cardiopulmonary resuscitation (CPR) guidelines by the Reassessment Campaign on Veterinary Resuscitation (RECOVER).MethodsA previously published online questionnaire from Switzerland was adapted and translated into 7 languages, corresponding to national languages in Austria, France, Germany, Ireland, Italy, Liechtenstein, Netherlands, Portugal, Spain, and the United Kingdom. The survey was distributed via respective national veterinary organizations and social media outlets. A subset of questions was analyzed to evaluate respondent demographics, RECOVER guideline awareness, and to allocate composite compliance scores for CPR preparedness, basic life support (BLS) and advanced life support (ALS). Percentages of group total (95% confidence interval) were calculated. Multivariable logistic regression was used to evaluate the effects of region of practice, gender, age, specialty training, and guideline awareness on compliance. Odds ratios (95% confidence interval) were generated and significance set at P &lt; 0.05.ResultsNine-hundred and thirty respondents were included in analysis. Awareness of and compliance with RECOVER guidelines varied widely across regions. Compliance with all assessed RECOVER guideline recommendations was highest in Germany/Austria [14% (7- 27%)] and lowest in France and Portugal [0% (0–3%)]. CPR preparedness compliance was higher in participants aware of RECOVER guidelines [OR 10.1 (5.2-19.5)], those practicing in Germany/Austria [OR 4.1 (1.9–8.8)] or UK/Ireland [OR 2.2 (1.3–3.7)], and lower in those practicing in Portugal [OR 0.2 (0.1–0.9)]. Specialty training [OR 1.8 (1.1–2.9)], guideline awareness [OR 5.2 (3.2–8.6)], and practice in Germany/Austria [OR 3.1 (1.5–6.5)], UK/Ireland [OR 2.6 (1.7–4.1)], or the Netherlands [OR 5.3 (2.0–14.2)] were associated with increased BLS compliance. ALS compliance was higher in participants with guideline awareness [OR 7.0 (2.9–17.0)], specialty training [OR 6.8 (3.8–12.1)], those practicing in Germany/Austria [OR 3.5 (1.3–9.6)], UK/Ireland [OR 4.0 (1.9–8.3)], or Spain [OR 3.2 (1.2–8.3)] and in younger survey participants [OR 0.9 (0.9–1.0)].ConclusionsAwareness and compliance with RECOVER guidelines varied widely among countries surveyed, however overall compliance scores in all countries were considered low. Further research may highlight factors surrounding poor guideline awareness and compliance so targeted efforts can be made to improve veterinary CPR in Europe.
RANCANG BANGUN SISTEM PELAPORAN KEUANGAN DI SMK WERDHI SILA KUMARA BERBASIS WEB
Authors: Darmawan I K. G. Wawan , Purnama I Nyoman , Estiyanti Ni Made 
Published: July 2022

<p>Abstrak. Salah satu bidang ilmu yang banyak dipengaruhi oleh kemajuan Teknologi Informasi adalah Sistem Informasi Akuntansi. Bidang pendidikan, khususnya sekolah dengan adanya pengembangan teknologi informasi dapat membantu perkembangan infrastruktur dan sistem informasi akuntansi berbasis komputer sehingga dapat membantu aktivitas pembuatan laporan keuangan di sekolah. SMK Werdhi Sila Kumara adalah satu lembaga sekolah yang belum memanfaatkan perkembangan Teknologi Informasi secara maksimal karena masih menggunakan sistem konvensional dalam pembuatan laporan keuangan. Laporan keuangan di SMK Werdhi Sila Kumara yang masih memiliki banyak kekurangan pada pengelolaan data dan pencarian data, data yang sudah di kumpulkan mudah hilang atau pun rusak dan rawan kesalahan dalam proses pencatatan. Penelitian ini dilakukan bertujuan untuk dapat membantu SMK Werdhi Sila Kumara dalam hal pembuatan laporan keuangan, perancangan dan pembangunan Website untuk Sistem Pelaporan Keuangan menggunakan Dalam Penelitian ini, peneliti menggunakan metode Software Development Life Cycle (SDLC) dengan model pengembangan Waterfall, menggunakan Database Mysql serta menggunakan framework CodeIgniter sehingga memudahkan dalam pembuatan website berbasis PHP. Kata kunci: Sistem Pelaporan Keuangan, Model Waterfall, System Developmen Life Cycle, Mysql, CodedIgniter</p><p>Abstract. One of the fields of science that is heavily influenced by advances in Information Technology is the Accounting Information System. The field of education, especially schools with the development of information technology can help the development of infrastructure and computerbased accounting information systems so that it can help the activities of making financial reports in schools. SMK Werdhi Sila Kumara is a school institution that has not made maximum use of Information Technology developments because it still uses conventional systems in preparing financial reports. Financial statements at SMK Werdhi Sila Kumara which still has many deficiencies in data management and data retrieval, the data that has been collected is easily lost or damaged and prone to errors in the recording process. This research was conducted aiming to be able to help SMK Werdhi Sila Kumara in terms of making financial reports, designing and building a Website for Financial Reporting Systems using in this Research, researchers use metode Software Development Life Cycle (SDLC) with a development model Waterfall. And using the Mysql Database and using the CodeIgniter framework making it easier to create PHP-based websites. Keywords: Financial Reporting System, Waterfall Model, System Development Life Cycle, Mysql, CodedIgniter </p>
Perancangan Sistem Point of Sales (POS) Terintegrasi pada UD. Akor Nature Bag
Authors: Widiastuti Putu Ari , Utami Nengah Widya , Estiyanti Ni Made 
Published: July 2022

<p><em>The UD. Akor Nature Bag Management does not yet have a good financial reporting system because it only relies on notes from sales. The management also cannot know the development of the company's branches in real time, because sales transactions are sent by the branch to the center once a week or once a month. This article presents the design of an integrated Point of Sales system, which is tailored to the needs of the UD Akor Nature Bag. The research method used is a system development method with a prototyping approach, starting from planning and ending with the proposed system design. Point of Sales system design includes context diagram design, data flow diagram design, system database design, and user interface design. The design of the user interface is made in the form of a static web and uses a template from Stisla.</em></p><p><strong><em>Keywords</em></strong><em>: System Design, Point of Sales System, Prototyping</em></p><p> </p><p>ABSTRAK. Manajemen UD Akor <em>Nature Bag</em> belum memiliki sistem pelaporan keuangan yang baik karena hanya mengandalkan nota-nota dari penjualan. Pihak manajemen juga tidak dapat mengetahui perkembangan cabang perusahaan secara <em>realtime</em>, karena transaksi penjualan dikirim oleh cabang ke pusat setiap satu minggu atau satu bulan sekali. Artikel ini menyajikan rancangan sistem <em>Point of Sales</em> terintegrasi, yang disesuaikan dengan kebutuhan pada UD Akor <em>Nature Bag</em>. Metode penelitian yang digunakan adalah metode pengembangan sistem dengan pendekatan <em>prototyping</em>, dimulai dari perencanaan dan berakhir pada perancangan sistem usulan. Perancangan sistem <em>Point of Sales</em> memuat rancangan diagram konteks, rancangan data <em>flow diagram</em>, rancangan <em>database</em> sistem, serta rancangan <em>user interface</em>. Rancangan <em>user interface</em> dibuat dalam bentuk web statis dan menggunakan <em>template</em> dari Stisla.</p><p><strong>Kata kunci</strong><strong>:</strong> Perancangan Sistem, <em>Sistem Point of Sales, Prototyping </em></p>