bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on liver histopathology of chronic HBV infected patients with different normal ALT values
Authors: Zeng Zhan , Hao Hongxiao , Bi Xiaoyue , Lin Yanjie , Yang Liu , Wang Shiyu , Shen Ge , Chang Min , Jiang Tingting , Deng Wen , Lu Huihui , Sun Fangfang , Lu Yao , Gao Yuanjiao , Liu Ruyu , Xu Mengjiao , Chen Xiaoxue , Hu Leiping , Zhang Lu , Li Minghui , Xie Yao 
Published: November 2022

AimsComparison of liver histopathological findings to explore the occurrence of liver inflammation in patients with chronic hepatitis B (CHB) under different alanine aminotransferase (ALT) normal values.MethodsThe patients who were diagnosed as chronic hepatitis B virus (HBV) infection by liver histopathology at the Department of Pathology, Beijing Ditan Hospital due to clinical difficulty in defining the degree of liver inflammation or fibrosis were retrospectively enrolled from May 2008 to November 2020. Study of the incidence of significant hepatic histopathology in enrolled patients according to different ALT normal values. Using logistic regression to investigate the relevant factors of significant hepatic histopathology.ResultsA total of 1474 patients were enrolled, 56.20% of the patients were male, and the overall patients’ age was 36.80 ± 10.60 years. 39.00% of patients had liver inflammation grade G &gt; 1, 34.70% liver fibrosis stage S &gt; 1, and 48.17% patients had significant hepatic histopathology (G &gt; 1 and/or S &gt; 1). Among patients with normal ALT values, 36.40% and 40.40% had significant hepatic histopathology by American Association for the Study of Liver Diseases (AASLD) criteria and Chinese guideline criteria, respectively, but the difference was not statistically significant (χ2 =3.38, P =0.066). In contrast, among patients with abnormal ALT values, 58.90% and 62.20% of patients had significant hepatic histopathology by AASLD criteria and Chinese guideline criteria, respectively, with no significant difference (χ2 =2.28, P =0.131). ALT (P &lt;0.001, OR=1.019), hepatitis B surface antigen (HBsAg) (P &lt;0.001, OR=0.665) and hepatitis B e antigen (HBeAg) status (P &lt;0.001, OR=2.238) were relevant factors in the occurrence of significant hepatic histopathology. ALT was positively corelated with grade of inflammation G (r =0.194, P &lt;0.001) and negatively correlated with liver fibrosis stage S (r =-0.066, P =0.021).ConclusionsOur study found no statistically significant differences in the presence of significant hepatic histopathology under the two ALT criteria. ALT, HBsAg and HBeAg status were related to the occurrence of significant hepatic histopathology.
Use of recycled coal bottom ash in reinforced concrete beams as replacement for aggregate
Authors: Karalar Memduh , Bilir Turhan , Çavuşlu Murat , Özkiliç Yasin Onuralp , Sabri Sabri Mohanad Muayad 
Published: November 2022

In this research, it is studied the crack and flexural behavior of reinforced concrete beams with various bottom ash ratios (BARs) considered as fine aggregate in an experimental and numerical investigation. For experimental purposes, different concrete series are considered varying aggregate sizes ranging from 0 to 25 mm. To supplement concrete, bottom ash is put to use in conjunction with material from 0–5 mm in size aggregate particles as replacement for fine aggregates with ratios of 25%, 50%, 75%, and 100%. Experiments were done to investigate the behavior of the beams and how flexural and fracture behaviors are represented. 75% BARs gave optimum results in terms of displacement capacity. Increasing BAR to 100% decrease deflection capacity of the beam. Also, ANSYS software is used to build 3D finite element models (FEMs) of beams to compare with experiment data. Experimental and 3D numerical tests show exceptionally tight flexural and fracture behaviors. Following this, a computer-generated structure is made by running SAP 2000, and the strength of the beams is then utilised in an RC structural model. Every stage of the building’s construction is thoroughly assessed utilizing multiple types of seismic testing, employing the SAP2000 program, with the resulting analysis providing significant findings on how the seismic force of 75% BAR affects horizontal displacement of each floor. The results showed that the weight of the structure dramatically decreases as the number of columns and RCBs are raised while also increasing the number of BARs. Moreover, the magnitude of earthquake and BAR have a significant effect on the horizontal displacement behavior of reinforced concrete structures. The strength of the concrete structure varies between close- and far-fault earthquakes, and for close-fault earthquakes, concrete strength is stronger than for far-fault earthquakes. This brings us to the second disadvantage of BAR which is the 75% strain produces a severe displacement of reinforced concrete structures. Besides, it was seen that the simulations and experiments yield tiny cracks with very identical configurations.
Evaluation of the cell-free DNA integrity index as a liquid biopsy marker to differentiate hepatocellular carcinoma from chronic liver disease
Authors: Kumar Sonu , Nadda Neeti , Paul Shashi , Gamanagatti Shivanand , Dash Nihar Ranjan , Vanamail Perumal , Saraya Anoop , Shalimar  , Nayak Baibaswata 
Published: November 2022

Background: Hepatocellular carcinoma (HCC) occurs in the majority of patients with underlying chronic liver disease (CLD) of viral and non-viral etiologies, which requires screening for early HCC diagnosis. Liquid biopsy holds great promise now for early detection, prognosis, and assessment of response to cancer therapy. Cell-free DNA (cfDNA) as a liquid biopsy marker can be easily detected by a real-time quantitative PCR (RT-qPCR) assay for a change in its concentration, integrity, and fragmentation in cancer.Methods: Patients with HCC (n = 100), CLD (n = 100), and healthy (n = 30) controls were included in the study. The cfDNA was isolated from serum and real-time quantitative PCR (RT-qPCR) was carried out using primer pairs for large (&gt;205 bp) and small (110 bp) fragments of repetitive elements (ALU and LINE1) and housekeeping genes (β-Actin and GAPDH). Total cfDNA concentrations and integrity index were determined by the absolute quantitation method (L/S ratio or cfDII-integrity). The cfDII as a measure of fragmentation was determined by comparative Ct (2–ΔΔCt) method of relative quantification (cfDII-fragmentation). Using a receiver operating characteristic (ROC) curve, cfDII-integrity and cfDII-fragmentation were used to differentiate HCC from CLD patients or healthy controls.Results: The total cfDNA concentrations in the sera of HCC (244 ng/ml) patients were significantly higher than those of CLD (33 ng/ml) patients and healthy (16.88 ng/ml) controls. HCC patients have shown poor DNA integrity or excess cfDNA fragmentation than CLD patients and healthy controls. The cfDII-integrity of GAPDH and ALU fragment significantly differentiate HCC from CLD at AUROC 0.72 and 0.67, respectively. The cfDII-fragmentation following normalization with cfDNA of healthy control has shown significant differential capabilities of HCC from CLD at AUROC 0.67 using GAPDH and 0.68 using the ALU element. The ROC curve of LINE1 and β-actin cfDII was not found significant for any of the above methods. The cfDII-fragmentation trend in HCC patients of different etiologies was similar indicating increased cfDNA fragmentation irrespective of its etiology.Conclusion: The cfDII measuring both DNA integrity (L/S ratio) and fragmentation of the Alu and GAPDH genes can differentiate HCC from CLD patients and healthy individuals.
Paget’s disease of the breast: Our 20 years’ experience
Authors: Scardina Lorenzo , Di Leone Alba , Magno Stefano , Franco Antonio , Biondi Ersilia , Sanchez Alejandro Martin , D’Archi Sabatino , Gentile Damiano , Fabi Alessandra , Masetti Riccardo , Franceschini Gianluca 
Published: November 2022

IntroductionPaget’s disease (PD) represents 1%–3% of all breast cancers and mostly occurs in postmenopausal women. Multiple studies have confirmed that breast-conserving surgery (BCS) followed by radiotherapy is a safe option for patients with in situ or invasive PD, ensuring local control and survival rates similar to those achieved with mastectomy.Materials and methodsWe retrospectively analyzed 115 patients affected by PD treated in our institution between January 2000 and May 2021. Median age at diagnosis was 60 years and median follow-up was 82 months; 69 patients were treated with BCS and 46 were treated with modified radical mastectomy or skin-sparing mastectomy.ResultsAt histological examination, 59 patients (59/115, 51.0%) had an underlying invasive carcinoma; in 11 patients (11/115, 9.0%), only PD was found. In 45 patients (45/115, 40.0%), only noninvasive cancer was found. Nine patients (9/115, 7.8%) developed a local recurrence, 7 patients (7/115, 6.0%) are alive with distant metastasis, and 10 patients (10/115, 8.6%) died.DiscussionIn our series, no statistically significant differences were shown between PD alone, PD associated with in situ cancer, and PD with invasive cancer, regardless of the surgical procedure. BCS followed by radiotherapy appears to be an effective and safe option for patients with PD.ConclusionPD is a rare form of breast cancer and, in half of the cases, is associated with an invasive carcinoma. Separating our sample into three subgroups based on tumor histology, there were no significant differences in terms of LC, DFS, and OS rate in patients treated with different types of surgery. This study presents some limitations due to its retrospective nature and being confined to a single institution.
Validation study of the Italian brief version of the multidimensional jealousy scale: Psychometric properties, measurement invariance across gender, and convergent validity
Authors: Diotaiuti Pierluigi , Valente Giuseppe , Mancone Stefania , Girelli Laura , Cavicchiolo Elisa , Chirico Andrea 
Published: November 2022

IntroductionThe multidimensional jealousy scale (MJS) is among the most internationally used instruments for the assessment of jealousy in its three dimensions: cognitive, emotional, and behavioral. This study aimed to replicate the Italian validation process of the shortened MJS in order to confirm its psychometric properties and measurement invariance across gender.Materials and methodsExploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted in a large sample of adults (n = 2,928). To reliably estimate mean differences across gender, the measurement invariance of the scale was first established by means of CFA. Convergent validity was than tested by administrating the tool to a convenient sample (n = 304).ResultsA 15-item version of the Italian MJS was retained in its three-factor structure. The tool showed good fit with both the CFA (χ2 = 211.827, CFI = 0.969, TLI = 0.959, RMSEA = 0.047, RMSEA 90% CI = 0.039–0.055) and the results confirmed the strong measurement invariance of the MJS across gender. The internal consistency measures were found to be fully satisfactory. Predictive associations with constructs such as avoidance and anxiety referred to attachment in relationships (ECR-R), obsessive jealousy, depressive jealousy, jealousy associated with separation anxiety, paranoid jealousy (QUEGE), and basic self-esteem (BSE) were confirmed.DiscussionThe MJS is particularly apt to collect information quickly and efficiently about jealousy in a current relationship. The multidimensional and brief structure makes it particularly suitable for preliminary screening, couple therapy assessment, and research purposes.
Visual attention span as a predictor of reading fluency and reading comprehension in Arabic
Authors: Awadh Faris H. R. , Zoubrinetzky Rachel , Zaher Ahmed , Valdois Sylviane 
Published: November 2022

IntroductionVisual attention span is a measure of multielement parallel processing. Individuals with higher visual attention span are expected to allocate more attention to letters within strings, which boosts letter identification and translates into more efficient reading. Given the high visual complexity of the Arabic writing system, we expected visual attention span to be an important predictor of reading in the Arabic language.MethodsNative Arabic readers from Grade 4 and Grade 5 were recruited in Iraqi schools. We assessed the contribution of visual attention span to their reading fluency performance in tasks of fully vowelized word and pseudo-word reading, non-vowelized text reading, and written text comprehension. Their phonological awareness, IQ, and single letter processing speed were further evaluated.ResultsResults showed that visual attention span was a significant unique predictor of all the reading measures. Visual attention span and phonological awareness accounted for a similar amount of variance in word and pseudo-word reading fluency. Visual attention span was a far higher predictor than phonological awareness for text reading fluency and the sole predictor of text comprehension.DiscussionThe role of visual attention span to reading is discussed by reference to current word recognition models. Higher involvement of visual attention is expected in vowelized script to compensate for increased crowding in the presence of diacritics. Visual attention would thus contribute to sub-lexical orthographic parsing and favor orthography-to-phonology mapping, in particular for the pseudo-words that do not benefit from efficient lexical feedback. In non-vowelized script, higher visual attention would enhance the accurate and fast identification of root letters within words, thus resulting in faster word recognition.
Development of a measure quantifying helpful psychotherapy interventions: The Helpful Therapeutic Attitudes and Interventions Scale
Authors: Li Xiaobao , Gu Hong , Zhao Xudong , Chen Fazhan , Liu Liang 
Published: November 2022

BackgroundDespite the number of empirical studies identifying the helpful factors correlated with beneficial psychotherapy outcomes, there is no validated scale that measures helpful therapeutic attitudes and interventions applied by therapists within the actual therapy process in China. In the current study, we developed the Helpful Therapeutic Attitudes and Interventions Scale (HTAIS) as an accessible client-rated instrument to measure useful interventions applied by the therapist during psychotherapy sessions.Materials and methodsBased on the results of previous literature and our prior psychotherapy process studies, a 40-item measure was initially designed. Two studies with a total of 2,780 Chinese participants who received psychotherapy were carried out to evaluate the structure, reliability, and validity of the developed scale.ResultsPrincipal component analysis yielded a three-component HTAIS containing 26 items. The scale included dimensions labeled “Empathy, respect and neutrality,” “Using techniques to solve practical issues,” and “In-depth exploration and expansion.” Confirmatory factor analysis showed the construct validity of the derived three components model. And the developed scale had high internal consistency and test-retest reliability. The scale scores of the HTAIS were positively correlated with those of the Working Alliance Scale and Session Rating Scale, as well as clients’ perceived therapy satisfaction, thus supporting its concurrent validity.ConclusionThe HTAIS allows an immediate examination, as experienced by the client, of the extent to which certain useful therapeutics interventions have been conducted during therapy and could help to improve the clinician’s subsequent therapy strategies. Future research is suggested to further validate the scale, especially to assess its psychometric properties in various populations with different clinical complaints.
Smoking cessation in the elderly as a sign of susceptibility to symptomatic COVID-19 reinfection in the United States
Authors: Ando Wataru , Horii Takeshi , Jimbo Mitsuki , Uematsu Takayuki , Atsuda Koichiro , Hanaki Hideaki , Otori Katsuya 
Published: November 2022

BackgroundWe aimed to clarify the relationship between coronavirus disease 2019 (COVID-19) reinfection and basic disease and smoking status.MethodsThe electronic health records of 165,320 patients with COVID-19 from January 1, 2020, to August 27, 2021, were analyzed. Data on age, race, sex, smoking status (never, current, former), and basic disease were analyzed using Cox proportional hazard models.ResultsIn total, 6,133 patients (3.7%) were reinfected. The overall reinfection rate for never, current, and former smokers was 4.2, 3.5, and 5.7%, respectively. Although the risk of reinfection was highest among former smokers aged ≥65 years (7.7% [422/5,460]), the reinfection rate among current smokers aged ≥65 years was 6.2% (341/5,543). Among reinfected patients, the number of basic diseases was higher in former smokers (2.41 ± 1.16) than in current (2.28 ± 1.07, P = 0.07) and never smokers (2.07 ± 1.05, P &lt; 0.001). Former smokers who are older may have been exposed to factors that increase their risk of symptomatic COVID-19 reinfection.
Three-dimensional ready-to-pick reservoir-based preconcentrator with a pillar-structured channel for miRNA applications
Authors: Lee Seungmin , Kim Jinhwan , Lee Na Eun , Kim Kang Hyeon , Park Seong Jun , Park Jeong Soo , Kim Cheonjung , Hong Ji Hye , Yoon Dae Sung , Yoo Yong Kyoung , Lee Jeong Hoon 
Published: November 2022

A sample preconcentration technique that exceeds a microfluidic device’s limited processing volume (up to microliters) is critical for real sample pretreatment applications. Here, we have developed a 3D-printed preconcentrator with a pillar structure (3DP2) to enrich the biological samples up to hundreds of microliter scales (700 μL) within 20 min by utilizing ion concentration polarization (ICP). We designed three-dimensional ready-to-pick reservoirs serially connected with a pillar-structured channel to enable large-volume preconcentration by balancing the preconcentrating forces (depletion, electrophoretic, and electroosmotic force) generated by ICP. Using the I-t and I-V curves, we confirmed that ICP performance was enhanced due to a pillar structure’s suppression of the vortex. Finally, we preconcentrated bovine serum albumin (BSA) and micro ribonucleic acid-21 (miRNA-21) two-fold. Moreover, depending on their size and charge, these were concentrated at different locations and could be extracted easily using pipettes. We believe that this study provides a novel strategy for downstream applications.
Conhecimento da equipe de enfermagem sobre produtos para limpeza de feridas
Authors: Albuquerque Brandão Maria Girlane Sousa , Coelho Erisson Moura , Araújo Thiago Moura de 
Published: November 2022

Introdução: Nos cuidados de saúde às pessoas com feridas, a equipe de enfermagem deve possuir conhecimento clínico e técnico para programar as intervenções terapêuticas, principalmente no que se refere aos produtos tópicos de limpeza. Objetivo: Identificar o conhecimento da equipe de enfermagem sobre produtos para limpeza de feridas. Materiais e Métodos: Pesquisa exploratória e quantitativa, realizada em janeiro e fevereiro de 2021, por meio da aplicação de questionários com 26 questões. Os participantes foram 102 enfermeiros, técnicos e auxiliares de enfermagem, que atuavam em três unidades de saúde no estado do Ceará, Brasil. Resultados: Na análise sobre o uso da água potável houve maior percentual de erros acerca dos produtos químicos presentes na água. Apenas 24,5% dos profissionais tinham conhecimento sobre o uso da água destilada e bidestilada quando há utilização de coberturas com prata. A maioria dos profissionais (62,7%) não tinha conhecimento sobre a solução mais recomendada para limpeza de feridas. Os itens com menor percentual de acertos foram sobre a influência da clorexidina e iodopovidona na resistência bacteriana (8,82%) e finalidade do antisséptico (11,76%). No item sobre a forma spray do polihexanida, 51,9% não souberam responder. Conclusão: Identificou-se déficit de conhecimento dos profissionais da equipe de enfermagem sobre produtos tópicos de limpeza de feridas, em aspectos fundamentais no manejo de limpeza de lesões e produtos tópicos.
uso dos resultados dos Conceitos Enade 2014 e 2017 dos cursos de licenciaturas do Instituto Federal de Educação, Ciência e Tecnologia de Goiás (IFG)
Authors: Costa de Oliveira Teixeira Álvares Camila 
Published: November 2022

O artigo analisa o uso dos resultados dos Conceitos Enade 2014 e 2017 para os cursos de licenciaturas do Instituto Federal de Educação, Ciência e Tecnologia de Goiás (IFG): ciências biológicas, ciências sociais, dança, física, matemática, música, pedagogia bilingue e química. Para tanto, ancora-se numa investigação bibliográfica e exploratória a partir de dados colhidos por meio da análise de documentos institucionais do instituto e dos relatórios do Exame Nacional dos Estudantes (Enade) do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP). Em relação às análises dos relatórios Enade dos dois ciclos avaliados, os dados analisados revelam que os diversos cursos de licenciatura do IFG são considerados com desempenho mediano e baixo, conforme os indicadores de qualidade desse exame, tendo mantido uma maior concentração ao conceito 3. O uso dos resultados do Enade ainda não refletiu como instrumento que possibilita ao IFG sanar possíveis dificuldades e propor ações de melhorias apresentadas nos seus cursos de licenciaturas.
Contribuições do Programa Residência Pedagógica na constituição de professores de ciências da natureza
Authors: Brum Rebolho Anderson , Penedo Batista Tailine , Gonçalves dos Santos Eliane 
Published: November 2022

O Programa Residência Pedagógica (RP) foi implementado em 2018, buscando oportunizar aos licenciandos em formação inicial uma maior vivência no âmbito escolar. Este estudo teve como objetivo investigar as contribuições do RP na constituição de Professores da área Ciências da Natureza em formação, a partir de situações vivenciadas pelos futuros professores/residentes nas escolas. Pesquisa qualitativa do tipo bibliográfica, com recorte temporal de 2018 a 2019. Para organização dos materiais foi utilizada a Análise de Conteúdo (AC). Da análise emergiram as categorias: i) Residência Pedagógica: o constituir-se professor; e ii) Residência Pedagógica: desafios, vivências, relações entre universidade e escola, as quais sinalizam que no processo formativo, a interação com as escolas, com os preceptores, ainda quando acadêmico, contribui substancialmente para o desenvolvimento da constituição docente do residente.
Review Ulang Area Percetakan Koran PT Sumsel Media Grafika dengan Pendekatan Activity Relationship Chart
Authors: Basuki Mahmud , Al-Amin M Yus , Suryani Faizah , Aprilyanti Selvia , Pratiwi Irnanda 
Published: November 2022

Tata letak adalah suatu cara dalam mewujudkan pengaturan fasilitas supaya optimal yang bertujuan dalam meminimalkan biaya produksi dan meningkatkan produktivitas. Tata letak yang tidak tepat seperti jarak gudang ke mesin cetak yang terlalu jauh akan berdampak pada pemborosan waktu proses produksi. Penelitian ini bertujuan untuk mereview tata letak percetakaan koran PT Sumsel Media Grafika dengan pendekatan metode activity relationship chart (ARC), dimana di dalam ARC terdapat 2 tahap yaitu ARD dan AAD. Hasil penelitian didapatkan hasil bahwa dari 10 departemen terdapat 4 departemen yang mengalami perubahan sehingga menjadi prioritas perbaikan, sehingga layout awal yang semula menggunakan area 750 m2 menjadi 450 m2 jika menggunakan layout alternatif. Sehingga area sisa seluas 300 m2 dapat disewakan.