bluuebunny/crossref_metadata_2025_split huggingface dataset:
SRPX2 attenuated oxygen–glucose deprivation and reperfusion-induced injury in cardiomyocytes via alleviating endoplasmic reticulum stress-induced apoptosis through targeting PI3K/Akt/mTOR axis
Authors: Sun Zhiyuan , Gao Xin 
Published: November 2022

Abstract
Myocardial infraction (MI) is the leading cause of high morbidity and mortality worldwide. It was still urgently needed to find new and effective drugs for MI treatment by the use of myocardial ischemia/reperfusion (I/R) model. Sushi repeats contain the protein X-Linked 2 (SRPX2), which regulates a variety of important cell functions. However, its possible role in myocardial I/R and the progression of MI is still unclear. In this study, we investigated the role of SRPX2 in myocardial I/R. SRPX2 showed low expression in IR rats and H9C2 cells induced by oxygen–glucose deprivation/reperfusion (OGD/R). SRPX2 could increase OGD/R-induced H9C2 cell survival. In addition, SRPX2 suppressed the apoptosis of OGD/R-induced H9C2 cells. Furthermore, we found that SRPX2 could inhibit ER stress induced by OGD/R in H9C2 cells. Mechanically, we found that SRPX2 suppressed the PI3K/Akt/mTOR pathway, thus attenuating OGD/R -induced injury in H9C2 cells. Therefore, SRPX2 has the potential to serve as a target for MI treatment.
Stable carbon and nitrogen isotope analyses of human and animal skeletal remains unearthed at Zengpiyan and Dayan sites in Guilin
Authors: Liu Xiaodi , Wang Ran , Hu Yaowu 
Published: November 2022

Abstract
Stable carbon and nitrogen isotope analyses, together with AMS radiocarbon dating of human and animal bones unearthed from the Zengpiyan and Dayan sites in Guilin of Guangxi suggest a relatively stable environment dominated by C3 plants, which was supplemented by a small amount of C4 plants. Although inhabitants of the two Neolithic sites relied mainly on freshwater resources, they differed significantly in their dietary structure from the Early to Middle phases. The Early Neolithic inhabitants (n=6) consumed similar foods in their diet. By contrast, the Middle Neolithic people (n=11) procured and consumed more terrestrial foods from diverse sources. The transition to a broad dietary spectrum was likely interlinked to the shifts in population structures, environmental adaptation, and foraging ranges.
Lexical variations in Asian Chinese speaking communities: a corpus-informed study of online, offline, and digital
Authors: Yip Jesse Wai Chi , Tang Sze-Wing 
Published: November 2022

Abstract
Studies on Chinese lexical variations, an emerging field in research of Global Chinese, remain scarce. Drawing upon the notion of onomasiological variation, this study employs corpus linguistics to examine semantic and grammatical characteristics of Chinese variations of three timely lexicons, including online, offline, and digital in the Greater China Region like the mainland of China, Taiwan, and Hong Kong, and overseas countries including Singapore and Malaysia. The results revealed Chinese variation patterns across regions and indicate two tendencies. First, the variations of a lexicon are identical to one another when the selected Chinese speaking communities tend to use different Chinese variations. Second, the variations are likely to be semantically variant when the communities have the same tendency in using the variations. This study argues that corpus linguistics is applicable and appropriate in the research of Chinese lexical variations, as it allows both quantitative and qualitative analysis.
Mother tongue to heritage language metamorphosis: the case of Mandarin Chinese in Canada
Authors: Makarova Veronika , Xiang Qin 
Published: November 2022

Abstract
This article compares Mandarin Chinese (MC) proficiencies of bi/multilingual children from immigrant families in Canada (BM) with those of monolingual (bidialectal) children (M) from China across two age groups (5–7 and 10–12). The purpose of the comparison is to identify the threshold of mother tongue to heritage language shift among Canadian bi/multilinguals. The results of bivariate ANOVA analysis of 28 speech parameters in children’s narratives elicited with the help of picture prompts demonstrate significant effects of language and age groups on proficiency parameters as well as interactions between language and age group factors. In the younger age group (5–7), bi/multilinguals proficiency is higher in six parameters, and lower in eight parameters, as compared to monolinguals, i.e., language proficiencies of bi/multilinguals are overall on par with those by monolinguals. By contrast, in the older participant group (10–12), there is a higher number of significant differences between BM and M participants (20 out of 28 parameters), and monolinguals have higher proficiencies in all these parameters. Furthermore, within the language group, cross-age comparisons display a significant improvement in 16 speech parameters for the older monolinguals group as compared to the younger group, but none at all for the bi/multilinguals older versus younger groups. The results suggest that for children from immigrant families in the given location and settings, the threshold of Mandarin Chinese shift from a mother tongue to a heritage language occurs between the ages of 8–9 and is largely completed by the age of 10–12, as evidenced by lack of further development of speech parameters in the 10–12 BM group. These results are explained by the impact of majority language education and other social factors.
香港社区词的词义研究
Authors: 孙 银新 
Published: November 2022

摘要
文章就香港社区词的词义进行探讨，主要研究以下四个问题：香港社区词词义的特点，香港社区词词义的形成方式，香港社区词中多义词的不同意义之间的联系方式，香港社区词词义关联方式与普通话词义关联方式上的异同。文章认为，概括起来，香港社区词里，无论是单义词还是多义词，在词汇意义的侧重点、词的色彩意义、词义的委婉含蓄程度、词义的构成理据等方面都呈现了鲜明的特点。香港社区词词义的形成方式主要有五种：依靠单个词素的借代意义构成社区词的词义，依靠单个词素的比喻意义构成社区词的词义，依靠单个词素的特有意义构成社区词的词义，依靠整个词中各个词素意义通过比喻构成社区词的词义，依靠整个词中各个词素意义通过借代构成社区词的词义。香港社区多义词词义的关联方式主要有以下七种：比喻、借代、特指、泛指、引申、类比、比拟等。香港社区词中的多义词跟共同语普通话里多义词在词义的关联方式上有同有异，二者都具有比喻、借代、特指、引申四类; 而泛指、类比、比拟是社区词词义特有的类型。
马来西亚华语程度副词的语体分布研究
Authors: 张 欣怡 , 王 晓梅 
Published: November 2022

提要：
相关文献显示，语体对程度副词的语法表现具有一定影响，而现有的马来西亚华语程度副词研究多基于单一语体语料，缺乏在书面语和口语中的语体分布考察。鉴于以上研究现状，本文采用语料库研究法，分别创建马来西亚华语书面语料库（476万字）和口语语料库（47.3万字），分析了71个程度副词的语体分布情况。同时采用比较研究法，将马来西亚华语与普通话进行比较，指出马来西亚华语程度副词语体分布的特殊性。研究结果发现，马来西亚华语程度副词根据其语体分布可分为五类：书面语性、书面语常用、通用、口语常用和口语性程度副词。此外，马来西亚华语与普通话语体分类一致的程度副词约占半数，而分类不一致的部分则体现出马来西亚华语“白的更白，文的更文”以及“文白混合”的特点。本研究对马来西亚华语程度副词的语体分布进行了系统性的梳理，挖掘其特殊性，希望能加深对马来西亚华语词类特点的认识。
Novel zero waste tactics for commercial vegetables – recent advances
Authors: Srenuja Dekka , Shanmugam Akalya , Nair Sinija Vadakkepulppara Ramachandran 
Published: November 2022

Abstract
Commercial vegetables include tomatoes, potatoes, onions, and eggplant due to their surplus production, availability, and affordability. The valorisation of the massive wastage of commercial vegetables and providing a long-term solution has been challenging. The review addresses the implications of biowastes on the environment and fosters the recent investigations into valorising commercial vegetable waste to develop multiple value-added products. It discussed the outcomes of the multiple technologies, majorly on green chemistry extraction, while outlining other methods such as fermentation, enzymatic treatments, 3D printing foods, high-pressure homogenisation, microencapsulation, bio-absorption method, and pyrolysis for their respective vegetable wastes. Agri-residues can be a valuable source for formulating functional ingredients, natural additives, biodiesel, dyes, and animal feed. This comprehensive review proposes a strategy to upcycle low-cost biowaste to boost the economic and ecological benefits. The current review captures the interests and great collaborations between researchers, industrialists, policymakers, waste management bodies, and eco-activists.
On arithmetic properties of solvable Baumslag–Solitar groups
Authors: Hayez Laurent , Kaiser Tom , Valette Alain 
Published: November 2022

Abstract
For

0
<
α
≤
1

0<\alpha\leq 1

, we say that a sequence

(

X
k

)

k
>
0

(X_{k})_{k>0}

of 𝑑-regular connected graphs has property

D
α

D_{\alpha}

if there exists a constant

C
>
0

C>0

such that

diam
⁡

(

X
k

)

≥

C
⋅

|

X
k

|

α

\operatorname{diam}(X_{k})\geq C\cdot\lvert X_{k}\rvert^{\alpha}

.
We investigate property

D
α

D_{\alpha}

for arithmetic box spaces of the solvable Baumslag–Solitar groups

BS
⁡

(
1
,
m
)

\operatorname{BS}(1,m)

(with

m
≥
2

m\geq 2

): these are box spaces obtained by embedding

BS
⁡

(
1
,
m
)

\operatorname{BS}(1,m)

into the upper triangular matrices in

GL
2

⁢

(

Z
⁢

[

1
/
m

]

)

\mathrm{GL}_{2}(\mathbb{Z}[1/m])

and intersecting with a family

M

N
k

M_{N_{k}}

of congruence subgroups of

GL
2

⁢

(

Z
⁢

[

1
/
m

]

)

\mathrm{GL}_{2}(\mathbb{Z}[1/m])

, where the levels

N
k

N_{k}

are coprime with 𝑚 and

N
k

∣

N

k
+
1

N_{k}\mid N_{k+1}

.
We prove that

if an arithmetic box space has

D
α

D_{\alpha}

, then

α
≤

1
2

\alpha\leq\frac{1}{2}

;

if the family

(

N
k

)

k

(N_{k})_{k}

of levels is supported on finitely many primes, the corresponding arithmetic box space has

D

1
/
2

D_{\smash{1/2}}

;

if the family

(

N
k

)

k

(N_{k})_{k}

of levels is supported on a family of primes with positive analytic primitive density, then the corresponding arithmetic box space does not have

D
α

D_{\alpha}

for every

α
>
0

\alpha>0

.

Moreover, we prove that if we embed

BS
⁡

(
1
,
m
)

\operatorname{BS}(1,m)

in the group of invertible upper-triangular matrices

T
n

⁢

(

Z
⁢

[

1
/
m

]

)

T_{n}(\mathbb{Z}[1/m])

, then every finite index subgroup of the embedding contains a congruence subgroup.
This is a version of the congruence subgroup property (CSP).
HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells
Authors: Wang Yuyan , Wang Jinfeng , Zhao Anqi , Huang Xin , Zhang Xin 
Published: November 2022

Abstract
Cervical cancer is the fourth most common cancer and the fourth leading cause of cancer death in women. Human papillomavirus (HPV16) E6/E7 heterogenous expression in C33A cells increased the mRNA and protein levels of KIF2A, while siRNA deletion of endogenous E6/E7 reduced the mRNA and protein levels of KIF2A in SiHa cells. KIF2A promoted cell migration and invasion, and regulated the expression of epithelial–mesenchymal transition-related proteins in C33A and SiHa cells. The exogenous expression of E6/E7 in C33A cells increased the phosphorylation of Akt, ERK, and JNK. However, Akt (API-2) and ERK (PD98059) inhibitors had no effect on the increase in KIF2A expression induced by E6/E7, while JNK inhibitors (JNK-IN-8 and SP600125) blocked the increase in KIF2A expression induced by E6/E7. The exogenous expression of E6/E7 increased the levels of transcription factor c-Jun, which is the classic substrate of JNK. Knockdown of c-Jun reduced the increase in KIF2A expression induced by E6/E7. In summary, KIF2A plays a key role in the motility and metastasis of cervical cancer. HPV16 E6/E7 can increase the levels of transcription factor c-Jun by activating the JNK signal, thereby up-regulating the transcriptional expression of KIF2A.
The Ras GTPase‐activating‐like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL‐1β release via exosomes
Authors: Liao Yun , Chen Xing , Miller‐Little William , Wang Han , Willard Belinda , Bulek Katarzyna , Zhao Junjie , Li Xiaoxia 
Published: November 2022

AbstractIL‐1β can exit the cytosol as an exosomal cargo following inflammasome activation in intestinal epithelial cells (IECs) in a Gasdermin D (GSDMD)‐dependent manner. The mechanistic connection linking inflammasome activation and the biogenesis of exosomes has so far remained largely elusive. Here, we report the Ras GTPase‐activating‐like protein IQGAP1 functions as an adaptor, bridging GSDMD to the endosomal sorting complexes required for transport (ESCRT) machinery to promote the biogenesis of pro‐IL‐1β‐containing exosomes in response to NLPR3 inflammasome activation. We identified IQGAP1 as a GSDMD‐interacting protein through a non‐biased proteomic analysis. Functional investigation indicated the IQGAP1‐GSDMD interaction is required for LPS and ATP‐induced exosome release. Further analysis revealed that IQGAP1 serves as an adaptor which bridges GSDMD and associated IL‐1β complex to Tsg101, a component of the ESCRT complex, and enables the packaging of GSDMD and IL‐1β into exosomes. Importantly, this process is dependent on an LPS‐induced increase in GTP‐bound CDC42, a small GTPase known to activate IQGAP1. Taken together, this study reveals IQGAP1 as a link between inflammasome activation and GSDMD‐dependent, ESCRT‐mediated exosomal release of IL‐1β.
The plant FYVE domain‐containing protein FREE1 associates with microprocessor components to repress miRNA biogenesis
Authors: Li Hongbo , Li Tingting , Li Yingzhu , Bai Haiyan , Dai Yanghuan , Liao Yanglan , Wei Juan , Shen Wenjin , Zheng Binglian , Zhang Zhonghui , Gao Caiji 
Published: November 2022

AbstractFYVE domain protein required for endosomal sorting 1 (FREE1), originally identified as a plant‐specific component of the endosomal sorting complex required for transport (ESCRT) machinery, plays diverse roles either in endosomal sorting in the cytoplasm or in transcriptional regulation of abscisic acid signaling in the nucleus. However, to date, a role for FREE1 or other ESCRT components in the regulation of plant miRNA biology has not been discovered. Here, we demonstrate a nuclear function of FREE1 as a cofactor in miRNA biogenesis in plants. FREE1 directly interacts with the plant core microprocessor component CPL1 in nuclear bodies and disturbs the association between HYL1, SE and CPL1. Inactivation of FREE1 in the nucleus increases the binding affinity between HYL1, SE, and CPL1 and causes a transition of HYL1 from the inactive hyperphosphorylated version to the active hypophosphorylated form, thereby promoting miRNA biogenesis. Our results suggest that FREE1 has evolved as a negative regulator of miRNA biogenesis and provides evidence for a link between FYVE domain‐containing proteins and miRNA biogenesis in plants.
Multivariable analysis to determine risk factors associated with abortion in mares
Authors: Roach J M , Arango-Sabogal J C , Smith K C , Foote A K , Verheyen K L , de Mestre A M 
Published: November 2022

Risk factors associated with equine reproductive efficiency have been identified along with those associated specifically with early pregnancy loss (EPL). In contrast, no studies have reported risk factors associated with abortion (loss between days 70 and 300 post-cover). Given the causes of abortion differ from those of EPL, likely too will the risk factors. A retrospective cohort study was carried out to identify risk factors associated with abortion in UK- and Irish-based Thoroughbreds, collecting data on 20 exposure variables over a 5-year period. A generalized linear mixed model was utilized to evaluate the associations between exposure variables and abortion, with clustering of observations accounted for at the mare and farm level. Variables with a likelihood ratio test (LRT) P value < 0.2 were entered into the model in a forward stepwise approach. Pregnancy outcome was available on 4439 pregnancies from 2510 mares. Having had two or more prior abortions (odds ratio (OR): 7.91, 95% CI: 2.86, 21.88), conceiving on the second or subsequent covered estrous cycle (OR: 1.84, 95% CI: 1.22, 2.78) and conceiving multiple conceptuses (OR: 1.68, 95% CI: 1.02, 2.76) were associated with an increased risk of abortion compared to null parous, first estrous cycle covers and singleton conceptions, respectively. Increasing paternal age (OR: 0.95, 95% CI: 0.90, 0.99) was associated with a decreasing risk of abortion. Mare and farm variance were not significant in the final model, LRT P = 0.43. These findings provide evidence-based data to inform Thoroughbred breeding management practices to help mitigate abortion risk.

Lay summary
This is the first study to identify the risk factors (characteristics which change the chance of an event) for abortion (miscarriage between days 70 and 300 of pregnancy) in the horse. Statistical models were used to account for the interactions between 20 different factors. The factor which increased the mare’s risk of having an abortion the most was when she had had two or more abortions prior to the pregnancy. Additionally, when the mare was initially pregnant with twins but one of those pregnancies was reduced, the remaining pregnancy was at an increased risk of aborting. Older mares were not at an increased risk of abortion like in humans; however, pregnancies fathered by older stallions were less likely to abort than those from younger stallions. The findings of this study can inform horse breeding practices to help reduce the chance of an abortion.
The Saudi Arabian Women Military Existence in the Islamic Perspective
Authors: Muis Afni Regita Cahyani , Matin Usep Abdul 
Published: November 2022

Purpose The purpose of this research was to explain in depth about the role of women army into Saudi Arabia’s military institutions in Mohammad Bin Salman regime. Method The study was a qualitative research with descriptive design using a primary data that were the journalists’ and academicians’ opinion or ideas. It used interviews with a researcher for the Center for Islamic and Occidental Studies, University of Darussalam Gontor, and with the journalist and academician from King Saud University. The study also depended on the secondary data literatures review like book, journal, and official website. The data then were analyzed qualitatively using the Islamic perspective of the women role in life. Results/FindingsAs a state which originally tightened the rules for women in the public sphere, the existence of women military in Saudi Arabia was a certain reformist. The engagement of woman military into the state affairs has contributed to Arab Saudi’s security stability that becomes the heart of Middle East as the most frequently visited by foreign people. It has a positive approach for improving the security system of Saudi Arabia as a global image builder. ConclusionThe urgency of women military in Saudi Arabia is to answer the public needs and service. Women Military in Saudi Arabia become a non-combatant for manifestation of the Kingdom of Saudi Arabia's vision to provide an opportunity for women into the public sphere. The Saudi Arabia's women military still maintains sharia principles as a political instrument.
Statistical Modeling using A New Hybrid Form of The Inverted Exponential Distribution with Different Estimation Methods
Authors: Adubisi O. D. , Adubisi C. E. 
Published: November 2022

This paper introduces a new four-parameter distribution called the exponentiated Gompertz generated inverted exponential (EGGIE) distribution. Explicit expressions of the structural properties such as the ordinary and incomplete moments, probability weighted moments, quantile function, Lorenz and Bonferroni curves, entropies, and order statistics are derived. The empirical findings indicate that the maximum likelihood procedure dominates the other estimators in the simulation study while the Cramer-Von Mises procedure dominates in the two real datasets applications. We demonstrate the superiority of the EGGIE distribution over the Gompertz Lomax, odd Fréchet Inverse exponential, generalized inverse exponential, generalized inverse exponential, exponential inverse exponential, and Gompertz Weibull distribution using the maximum likelihood procedure utilizing two real datasets applications. The findings show that the EGGIE distribution yields the best goodness of fit to the two datasets.Keywords: exponentiated Gompertz generated family; inverse exponential distribution; Kolmogorov-Smirnov statistic; Anderson-Darling; maximum product spacing. AbstrakPaper ini memperkenalkan distribusi 4-parameter baru yang disebut dengan distribusi exponentiated Gompertz generated inverted exponential (EGGIE). Ekspresi eksplisit sifat struktural dari distribusi ini diturunkan, seperti momen biasa dan momen tak lengkap, momen probabilitas terboboti, fungsi kuartil, kurva Lorenz dan Bonferroni, entropi, dan statistik urutan. Temuan empiris menunjukan bahwa prosedur maksimum likelihood mendominasi estimator lainnya pada studi simulasi, sementara prosedur Cramer-Von Mises mendominasi pada aplikasi dua dataset nyata. Peneliti menunjukkan keunggulan dari distribusi EGGIE dibandingkan distribusi Gompertz Lomax, odd Frechet Inverse exponential, generalized inverse exponential, exponential inverse exponential, dan Gompertz Weibull menggunakan metode maksimum likelihood yang diaplikasikan pada dua dataset nyata. Hasil menunjukan bahwa distribusi EGGIE menghasilkan kecocokan model yang baik pada kedua dataset.Kata Kunci: keluarga bangkitan exponentiated Gompertz; distribusi inverse exponential; Kolmogorov-Smirnov statistic; Anderson-Darling; maximum product spacing. 2020MSC: 62E10
Implementation of machine learning models to determine the appropriate model for protein function prediction
Authors: Golenko Yekaterina ,  Ismailova Aisulu , Shaushenova Anargul , Mutalova Zhazira , Dossalyanov Damir , Ainagulova Aliya , Naizagarayeva Akgul 
Published: November 2022

Predicting the function of proteins is a crucial part of genome annotation, which can help in solving a wide range of biological problems. Many methods are available to predict the functions of proteins. However, except for sequence, most features are difficult to obtain or are not available for many proteins, which limits their scope. In addition, the performance of sequence-based feature prediction methods is often lower than that of methods that involve multiple features, and protein feature prediction can be time-consuming. Recent advances in this field are associated with the development of machine learning, which shows great progress in solving the problem of predicting protein functions. Today, however, most protein sequences have the status of «uncharacterized» or «putative».
The need to assess the accuracy of identification of protein functions is an urgent task for machine learning approaches used to predict protein functions. In this study, the performance of two popular function prediction algorithms (ProtCNN and BiLSTM) was assessed from two perspectives and the procedures for building these models were described.
As a result of the study of Pfam families, ProtCNN achieves an accuracy rate of 0.988 % and bidirectional LSTM has an accuracy rate of 0.9506 %. The use of the Pfam dataset allowed increasing the classification accuracy due to the large training dataset. The quality of the prediction increases with a large amount of training data.
The study demonstrated that machine learning algorithms can be used as an effective tool for building protein function prediction models, in particular, the CNN network can be adapted as an accurate tool for annotating protein functions in the presence of large datasets.