bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective randomized controlled study on the role of restoring liver diaphragm surface tension and pain control at port sites in optimizing pain management following laparoscopic cholecystectomy
Authors: Abuelzein Mohamed Lotfy Ali , Baghdadi Mohamed Ali , Abbdelhady Waleed Ahmed , Khairy Mostafa Mohamed 
Published: July 2022

AbstractIntroductionAfter laparoscopic cholecystectomy (LC), pain is still a significant concern leading to extended hospital stays or readmissions. A standardized strategy is needed to offer effective pain relief postoperatively. The pain in the early postoperative period is mainly due to elimination of intraperitoneal surface tension. The aim of this study is to evaluate the restoration of intraabdominal surface tension and the use of bupivacaine‐soaked tachosil to control parietal abdominal pain at the port sites to optimize postoperative pain management.Patients and methodsBetween March 2020 to December 2021, 816 patients undergoing LC were randomized into two groups after exclusion of 12 patients: Group A—interventional contained 402 patients; Group B—control contained 402 patients. Data to be compared were made in terms of operative time, shoulder pain, upper abdominal pain, and number of analgesic doses and hospital stay. Pain intensity was assessed by using the visual analog scale.ResultsThere was no significant variation in the demographic data between the two groups. There was significant statistical difference between Groups (A) and (B) regarding severity of shoulder pain and port site pain and number of analgesic doses and hospital stay in favor of Group (A). The results were evaluated within 95% confidence intervals and significance was determined as P < .05.ConclusionThe restoration of intraabdominal surface tension by absorbing as much CO2 as possible at the end of laparoscopic cholecystectomy via the epigastric port route, as well as the use of bupivacaine‐soaked tachosil to control parietal abdominal pain at the port sites; both steps significantly improved postoperative pain management, reduced the number of analgesic doses, and decreased the length of hospital stay.
Organocatalytic Asymmetric 3‐Allenylation of Indoles via Remote Stereocontrolled 1,10‐Additions of Alkynyl Indole Imine Methides
Authors: Wang Ziyang , Cheng Yuyu , Yue Zhibin , Chen Xuling , Li Pengfei , Li Wenjun 
Published: July 2022

AbstractA chiral phosphoric acids catalyzed regio‐ and enantioselective 1,10‐conjugate addition of 2‐arylindoles to alkynyl indole imine methides formed in situ from α‐(6‐indolyl)propargylic alcohols has been developed. With the established system, organocatalytic asymmetric 3‐allenylation of indoles was realized, affording a broad scope of axially chiral tetrasubstituted allenes bearing two indole motifs in high yields with stereoselectivities. Importantly, the organocatalytic remote stereocontrolled strategy disclosed the asymmetric 3‐allenylation of indoles via 1,10‐conjugate addition for the first time.
Sp‐Hybridized Nitrogen as New Anchoring Sites of Iron Single Atoms to Boost the Oxygen Reduction Reaction
Authors: Li Meiping , Lv Qing , Si Wenyan , Hou Zhufeng , Huang Changshui 
Published: July 2022

AbstractCarbon supported single‐atom catalysts with metal‐Nxconfiguration are considered as one of the most efficient catalysts for the oxygen reduction reaction (ORR). However, most of the metal‐Nxactive sites are composed by pyridinic N at the defect locations of graphene‐like supports. Here, we employ graphdiyne (GDY) as a new carbon substrate to synthesize an iron (Fe) single atom catalyst (Fe−N−GDY), showing excellent catalytic performance. Benefitting from the abundant acetylenic bonds in GDY, sp‐N anchored metal atoms are created without forming defects. The sp‐N and OH ligands regulate the electronic structure of Fe atoms and optimize the adsorption energy of ORR intermediates on the active sites by reducing the electron local density of Fe atoms, which accelerates the reaction kinetics and promotes the ORR activity of Fe−N−GDY. Furthermore, the practical application of Fe−N−GDY is corroborated by its high power density and long‐term performance via assembling a zinc–air battery.
A review on self‐healing polymers for applications in spacecraft and construction of roads
Authors: Goyal Megha , Agarwal Satya Narayan , Bhatnagar Nitu 
Published: July 2022

AbstractSelf‐healing polymers (SHP) are the polymers that have the capability to recover the material from any physical damage by responding to the damages or cracks in the material and heal the same. This self‐healing technology gives the polymers ability to recover from the cracks at an early stage by preventing them from any catastrophic failures, which increases the scope of applications of these materials. This review article highlights the key points on extrinsic self‐healing polymer and intrinsic self‐healing polymer by comparing their healing efficiency, advantages, disadvantages, and challenges in the prospect of their future development as well as their possible applications in space industry and construction of roads.
Preparation of p‐fluoroaniline modified graphene oxide composite and its application in polyurethane weatherproof coating
Authors: Wu Jianhua , Li Meng , Cao Ying , He Jianmin , Xue Mingjin , Zhu Aoqi , Huang Yongyi , Xu Yiting , Zeng Birong , Dai Lizong 
Published: July 2022

AbstractPolyurethane is a promising topcoat in anticorrosive coating system. As a topcoat, the study on improving its weathering resistance is significative. In this work, we present an anticorrosive filler, named GOFA based on p‐fluoroaniline chemical modified graphene oxide, and explored the potential of GOFA to improve the weatherability and corrosion resistance of polyurethane coatings. The results of the comprehensive experimental studies showed that the addition of 0.5 wt.% GOFA leaded to an improvement in the hydrophobicity of the polyurethane coating and the composite coating exhibits an excellent shielding effect against corrosive media. At the same time, the ultraviolet aging resistance the GOFA modified polyurethane composite coating also showed satisfactory results. It is inspired that adding a small amount of GOFA can make the composite polyurethane coating have excellent anti‐corrosion performance and weather resistance.
Oxidized multiwalled carbon nanotube reinforced rheological examination on Gum ghatti‐cl‐poly(acrylic acid) hydrogels
Authors: Kamaliya Bhagvan , Dave Pragnesh N. , Macwan Pradip M. 
Published: July 2022

AbstractThe intention of the present study was to synthesize Gum ghatti‐cl‐poly(acrylic acid)/‐o‐MWCNT hydrogel by free radical copolymerization method where the role of various ingredients are as: Gum ghatti as biopolymer (GG), acrylic acid (AA) as a probe for synthetic monomer, ammonium persulfate as initiator and methylene bis‐acrylamide (MBA) as a crosslinker. The oxidized multiwalled nanocarbon tubes (‐o‐MWCNT) with variable amounts (0–50 mg) were used as fillers. The as‐prepared hydrogels were characterized by X‐ray diffraction, scanning electron microscope and Fourier transform infrared spectroscopy. The rheological investigation of hydrogels revealed that the storage modulus (G′) was always higher than the loss modulus (G″) in the linear viscoelastic region over the entire frequency range. The persistent covalence crosslinking is responsible for the solid‐like behavior and elastic nature (G′ > G″). Hydrogels containing Gum ghatti‐cl‐poly(acrylic acid)/‐o‐MWCNT increased with strain. The nonlinear oscillatory shear increases by the addition ‐o‐MWCNT. The features shown highlight the potential of Gum ghatti‐cl‐poly(acrylic acid)/‐o‐MWCNT hydrogels for agricultural, medicinal, and pharmaceutical applications.
Design of proton conducting solid biopolymer blend electrolytes based on chitosan‐potato starch biopolymers: Deep approaches to structural and ion relaxation dynamics of H+ ion
Authors: Abdulwahid Rebar T. , B. Aziz Shujahadeen , Kadir Mohd F. Z. 
Published: July 2022

AbstractThe need for flexible energy storage devices for advanced technologies has encouraged researchers to focus on environmental‐friendly biopolymers. In this work, chitosan (CS) and potato starch (PS) biopolymers are blended to prepare proton conducting solid electrolytes. Based on the X‐ray diffraction (XRD) inspection, the most amorphous blended film with the lowest crystallinity degree was selected to prepare polymer electrolytes. The variation in Fourier‐transform infrared spectroscopy (FTIR) bands were used to investigate the occurrence of interactions among the ammonium thiocyanate (NH4SCN) salt and CS:PS polymer blends. The experimental results of electrochemical impedance spectroscopy (EIS) were simulated with electrical equivalent circuit (EEC) modeling to determine the circuit elements. The highest value of S cm−1 was recorded for the sample included 40 wt.% of dopant salt. The dielectric analyses were helpful in separating the regions ascribed to electrode and molecular polarizations. The combination of circuit elements achieved from the EEC modeling and Koops phenomenological interpretation is used to understand the behavior of the loss tangent (tanδ) pattern. The AC conductivity pattern followed Jonscher's power law. The relaxation dynamics interrelated with ions is explained using electric modulus approaches. The peaks hidden in the dielectric loss () spectra, were manifested in the imaginary part of electric modulus () pattern. The ‐ patterns were used to shed light on the coupling between ionic motion and polymer chain dynamics.
Smart carboxymethyl cellulose/polythiophene hydrogel for electrically driven soft actuators: Physical and thermal properties and electroactive performances
Authors: Danmatam Nanticha , Nakburee Wanwipa , Pearce John , Pattavarakorn Datchanee 
Published: July 2022

AbstractNovel electroactive hydrogels were fabricated from carboxymethyl cellulose (CMC) biopolymer incorporated with conductive polythiophene (PTh). The PTh particles dispersed uniformly in the CMC matrix providing higher mechanical properties and thermal stability. The formulation CMC/PTh6 (6%wt PTh) gave the highest tensile strength and elongation at break (0.9456 ± 0.0017 MPa and 123.0398 ± 7.0606%, respectively). The bending response of the hydrogels under an applied electric field was studied in terms of bending angle and bending sensitivity. Under an electric field strength of 100 V mm−1, CMC/PTh10 (10%wt PTh) showed the highest bending angle (52.245 ± 6.054°) while neat CMC gave the lowest bending angle (33.753 ± 8.116°). The bending behavior upon the application of an electric field of the CMC/PTh hydrogels occurs from the polarization of Na+and H+in the CMC matrix and S+in PTh.
Integration of shallow geophysics, archaeology and archival photographs to reveal the past buried at Ingleside Plantation, Piedmont North Carolina (USA)
Authors: Cowan Ellen A. , Seramur Keith C. , Costa January W. , Bradley‐Lewis Neeshell , Marshall Scott T. 
Published: July 2022

AbstractGround penetrating radar supported by electrical resistivity tomography and gradiometer surveys were used to map buildings and infrastructure documenting sequential property use by three generations of the Jacob Forney family who began as farmers in the backcountry of North Carolina and rose to prominence in government and industry within the Southeastern United States. At Ingleside, the antebellum plantation house has been preserved, and the adjacent property remains relatively undisturbed. Context for the geophysical surveys was provided by archival photographs, written accounts including monographs and newspaper articles, and an archaeological excavation of the stone hearth within the plantation's summer kitchen. The location of an early log home with a stone‐lined cellar with ties to the Piedmont Campaign of the American Revolution (in 1781) was newly discovered. In addition, a historic road, kitchen garden, and the postholes from an early post‐in‐the‐ground building were imaged within the subsurface. The external summer kitchen and privy are associated with the plantation house constructed in 1817. Several cesspool vaults of potential privies are ingrown with trees. The results of the geophysical surveys document the evolving land use within one family in the American South and can be connected to a specific event in history, a goal of historical archaeology.
Sex differences in rTMS treatment response: A deep learning‐based EEG investigation
Authors: Adamson M. , Hadipour A. L. , Uyulan C. , Erguzel T. , Cerezci O. , Kazemi R. , Phillips A. , Seenivasan S. , Shah S. , Tarhan N. 
Published: July 2022

AbstractIntroductionThe present study aimed to investigate sex differences in response to repetitive transcranial magnetic stimulation (rTMS) in Major Depressive Disorder (MDD) patients. Identifying the factors that mediate treatment response to rTMS in MDD patients can guide clinicians to administer more appropriate, reliable, and personalized interventions.MethodsIn this paper, we developed a novel pipeline based on convolutional LSTM‐based deep learning (DL) to classify 25 female and 25 male patients based on their rTMS treatment response.ResultsFive different classification models were generated, namely pre‐/post‐rTMS female (model 1), pre‐/post‐rTMS male (model 2), pre‐rTMS female responder versus pre‐rTMS female nonresponders (model 3), pre‐rTMS male responder vs. pre‐rTMS male nonresponder (model 4), and pre‐rTMS responder versus nonresponder of both sexes (model 5), achieving 93.3%, 98%, 95.2%, 99.2%, and 96.6% overall test accuracy, respectively.ConclusionThese results indicate the potential of our approach to be used as a response predictor especially regarding sex‐specific antidepressant effects of rTMS in MDD patients.
Is Alzheimer's disease an infectious neurological disease? A review of the literature
Authors: Uwishema Olivier , Mahmoud Ashraf , Sun Jeffrey , Correia Inês F. Silva , Bejjani Niovi , Alwan Maria , Nicholas Aderinto , Oluyemisi Adekunbi , Dost Burhan 
Published: July 2022

AbstractIntroductionAlzheimer's disease (AD) is a leading cause of dementia around the globe. Its pathogenesis is characterized primarily by the extracellular deposition of amyloid β peptides and intracellular neurofibrillary tangles. Despite the significant investments in neurological research, the exact molecular mechanism of AD pathogenesis is still not fully elucidated. Several studies converge on a hypothesis that pathogenic microbes might play a role in AD progression. Although this hypothesis has been considered relatively weak for decades, it has recently received considerable attention due to increasing evidence on the association between microorganisms and AD. There is a lack of experimental and scientific arguments conveying that these microorganisms engender cognitive and neuropathological deficits and modifications specific to AD, challenging the theory that it could be an infectious neurological disease. This review focuses on recent advances in the infection hypothesis and provides an overview of new findings portraying the significance of pathogenic microbes in AD and the challenges confronting the validity of the hypothesis.MethodologyData were collected from medical journals published on PubMed, Ovid MEDLINE, ScienceDirect, and Embase bibliographical databases with a predefined search strategy. All articles considering neurological disorders, especially AD associated with infectious diseases, were included.ResultsThis work focused on providing an overview of new findings around the relationship between microorganisms and AD, challenges facing the validity of the theory, and recommendations on how the scientific community can best develop alternative approaches to address the pathophysiology of AD.ConclusionWhile many studies reinforce the suspicion of an infectious etiology of AD, it is important to note that it is yet not validated how microorganisms’ presence in the brain can develop AD due to the limited available evidence. Certainly, ground‐breaking work is mandatory in this field of research, and these reports so far warrant a thorough investigation into how a chronic infection may remain silent while progressing its neuroinflammation. Amid this uncertainty arises the hope that many researchers will take on this challenge and join this endeavor to benefit AD patients worldwide.
Nanoalbumin–prodrug conjugates prepared via a thiolation‐and‐conjugation method improve cancer chemotherapy and immune checkpoint blockade therapy by promoting CD8+ T‐cell infiltration
Authors: Chen Long , Xu Nuo , Wang Pan , Zhu Haichuan , Zhang Zijian , Yang Zhanqun , Zhang Wenyuan , Guo Hongyan , Lin Jian 
Published: July 2022

AbstractProtein–drug conjugates are emerging tools to combat cancers. Here, we adopted an indirect thiolation‐and‐conjugation method as a general strategy to prepare protein–drug conjugates. We found for the first time that this method led to the formation of nanometric conjugates, probably due to the formation of intermolecular disulfide bonds, which facilitated enhanced uptake by cancer cells. As a proof‐of‐concept application in cancer therapy, a nanometric albumin–doxorubicin prodrug conjugate (NanoAlb‐proDOX) was prepared. The nanometric size promoted its uptake by cancer cells, and the prodrug characteristic defined its selective cytotoxicity toward cancer cells in vitro and reduced side effects in vivo. In multiple tumor xenograft models, nanometric NanoAlb‐proDOX showed superior antitumor activity and synergy with immune checkpoint blockade, probably due to the synergistically enhanced tumor CD8+ T‐cell infiltration and activation. Hence, the thiolation‐and‐conjugation strategy may serve as a generally applicable method for preparing drug conjugates, and the proof‐of‐concept nanometric albumin–doxorubicin conjugate may be a good choice for antitumor therapy with the ability to co‐stimulate the efficacy of immune checkpoint blockade.
Thirty years of Thiel embalming—A systematic review on its utility in medical research
Authors: Hammer Niels 
Published: July 2022

AbstractIn 1992, Walter Thiel described and embalming method that rendered “lifelike” tissues. Over the last 30 years, the Thiel method has been introduced worldwide for medical training and scientific purposes. This review examines research which can be linked to the use of Thiel embalming. A systematic review was performed to identify articles published in the following categories: research content, disciplines involved, sources and quantities of tissues deployed, and changes in research scope related to changes in the chemical composition of Thiel embalming. Four‐hundred twenty‐four publications were included. A number of adaptations to the original Thiel protocol were found, aiming to provide suitable tissue‐substitutes in the development of emerging medical technologies or procedures. Musculoskeletal surgery, anesthesia and intensive care were the most common disciplines that used Thiel embalmed tissues for research. Anatomy and biomechanics played a lesser role. An increase over time was observed in research outputs related to the Thiel method, while the number of specimens used per study decreased. The main centers using Thiel embalming were in Graz, Dundee, Sapporo, Bern, Zurich and Ghent, which jointly accounted for more than 54% of all research conducted using this method. Following three decades of use, the Thiel method has evolved into being a well‐established embalming technique for research purposes. Its future is challenged by the demanding requirements on both technical facilities and personnel, limitations of certain chemicals for use as fixatives, costs, and questions as to how “lifelike” the embalmed‐tissues are from an objective standpoint, all of which warrants future investigations.
WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma
Authors: Qin Yong , Wang Chao‐Jun , Ye Hai‐Lin , Ye Guan‐Xiong , Wang Shi , Pan De‐Biao , Wang Jun , Shen He‐Juan , Xu Sheng‐Qian 
Published: July 2022

AbstractHepatocellular carcinoma (HCC) is a common liver cancer that accounts for 90% of cases. Doxorubicin exhibits a broad spectrum of antitumor activity and is one of the most active agents in HCC. WW domain‐containing protein 2 (WWP2) is highly expressed in HCC tissues and activates protein kinase B (AKT) signaling pathway to enhance tumor metastasis. However, the role of WWP2 in the glycolysis and antitumor effects of doxorubicin and the epigenetic alterations of WWP2 in HCC remain to be elucidated. The levels of WWP2 and N6‐methyladenosine methyltransferase‐like 3 (METTL3) in clinical samples and cells were investigated. WWP2 were silenced or overexpressed to study the role of WWP2 in regulating cell proliferation, colony formation, and glycolysis. RNA immunoprecipitation was performed to test m6A levels. Quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) and Western blot were used to measure mRNA and protein, respectively. WWP2 silencing inhibits cell proliferation, colony formation, and glycolysis, while WWP2 overexpression has the inverse effects via the AKT signaling pathway. Silencing WWP2 enhances doxorubicin's antitumor effect, while WWP2 overexpression suppresses doxorubicin's antitumor effect. Data also support that METTL3 mediates WWP2 m6A modification, and m6A reader, IGF2BP2, binds to the methylated WWP2 to promote the stability of WWP2, leading to upregulation of WWP2. METTL3 mediates WWP2 m6A modification, which can be recognized and bound by IGF2BP2 to increase the stability of WWP2, leading to WWP2 overexpression which inhibits the antitumor effects of doxorubicin through METTL3/WWP2/AKT/glycolysis axis.
Facilitation techniques to cross the interatrial septum with intracardiac echocardiography during left atrial appendage closure
Authors: Vanhaverbeke Maarten , Nuyens Philippe , Bieliauskas Gintautas , Sondergaard Lars , Vejlstrup Niels , De Backer Ole 
Published: July 2022

AbstractObjectivesThis study aimed to assess the rate of difficult interatrial septum (IAS) crossing with the intracardiac echocardiography (ICE) probe during percutaneous left atrial appendage (LAA) closure and to identify techniques that facilitate IAS crossing with the ICE probe.BackgroundPercutaneous LAA closure is increasingly performed by ICE guidance. Although such an approach omits the need for general anesthesia, crossing of the IAS with the ICE probe may sometimes be challenging.MethodsAll consecutive patients that underwent ICE‐guided percutaneous LAA closure with an Amplatzer Amulet (Abbott) or WatchmanFLX (Boston Scientific) at our center in the period 2018–2021 were included. Cases in which IAS crossing with ICE was difficult were identified and techniques used to facilitate IAS crossing were identified and listed.ResultsIn 17 (5%) out of 354 cases, IAS crossing with the ICE probe was difficult and required use of additional techniques. Ultimately, IAS crossing was also successful in these 17 cases by using one of three possible facilitation techniques: the probing technique (12 cases), the double‐wire technique (3 cases), and the snaring technique (2 cases). In one case, the double‐wire technique was converted to the snaring technique, as crossing of the ICE probe remained challenging despite the use of two stiff guidewires.ConclusionCrossing of the IAS with the ICE probe can be challenging in 5% of ICE‐guided percutaneous LAA closure procedures. Operators should be aware of possible facilitation techniques in challenging cases, as these show to be safe and effective.
Treatment of cardiac device‐related infective endocarditis utilizing the new T20 curve catheter and flow saver with the Inari mechanical aspiration system
Authors: Whitbeck Matthew G. , Chambers Jeffrey W. 
Published: July 2022

AbstractEmerging innovations have led to the development of tools and techniques to perform mechanical aspiration of right‐sided endocarditis vegetations. However, blood loss during aspiration, the need for veno–veno bypass, and nonsteerable catheters have limited expansion of these treatment options to more patients. We present a case of pacemaker lead endocarditis treated with the Inari mechanical aspiration system utilizing the new T20 curved catheter (Inari Medical).