bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data fusion of multiple‐information strategy based on Fourier transform near infrared spectroscopy and Fourier‐transform mid infrared for geographical traceability of Wolfiporia cocos combined with chemometrics
Authors: Li Lian , Zhang Song , Zuo Zhi‐Tian , Wang Yuan‐Zhong 
Published: July 2022

AbstractOwing to the widespread concern relating to herb safety and quality, there is a momentum to discriminate the geographical traceability of fungus with multiple‐information technologies. In this study, we attempted to evaluate the fusion strategy of multiple‐information for the geographical traceability of this fungus based on Fourier transform near infrared spectroscopy (FT‐NIR) and Fourier‐transform mid infrared spectroscopy (FT‐MIR) with chemometrics. From all results, (1) comparative visualization of t‐distributed stochastic neighbor embedding (t‐SNE) emerged that the superior effect of FT‐NIR spectroscopy was better than FT‐MIR, which were separated according to the samples of different regions; (2) in view of optimized spectrum, the geographical traceability of extreme learning machine (ELM) model was better than the partial least squares discriminant analysis (PLS‐DA) and support vector machine (SVM) models that the accuracy of training set for all models was 100%; (3) the accuracy of train and test for ELM model were 100% with single spectrum, low‐level, and mid‐level fusion of FT‐NIR and FT‐MIR based on principal components (PCs) and competitive adaptive weighting algorithm (CARS), which was suitable for geographical traceability and evaluation of this fungus. (4) The three models based on successive projection algorithm (SPA) were not dissatisfied for the geographical traceability of this fungus. (5) The result of hierarchical cluster analysis (HCA) was consistent with the above results, which could distinguish samples according to different regions. All results showed that models could be developed as superior model on the foundation of single spectrum based on FT‐NIR, low‐level or mid‐level (except SPA) fusion of ELM, which could be employed in geographical traceability of Wolfiporia cocos, effectively.
Prussian Blue Type Cocatalysts for Enhancing the Photocatalytic Water Oxidation Performance of BiVO4
Authors: Meng Xiangyu , Xu Shiming , Zhang Chenchen , Feng Pengfei , Li Rui , Guan Hongxia , Ding Yong 
Published: July 2022

AbstractThe efficiency of photocatalytic overall water splitting reactions is usually limited by the high energy barrier and complex multiple electron‐transfer processes of the oxygen evolution reaction (OER). Although bismuth vanadate (BiVO4) as the photocatalyst has been developed for enhancing the kinetics of the water oxidation reaction, it still suffers from challenges of fast recombination of photogenerated electron‐hole pairs and poor photocatalytic activity. Herein, six MII‐CoIII Prussian blue analogues (PBAs) (M=Mn, Fe, Co, Ni, Cu and Zn) cocatalysts are synthesized and deposited on the surface of BiVO4 for boosting the surface catalytic efficiency and enhancing photogenerated carries separation efficiency of BiVO4. Six MII‐CoIII PBAs@BiVO4 photocatalysts all demonstrate increased photocatalytic water oxidation performance compared to that of BiVO4 alone. Among them, the Co−Co PBA@BiVO4 photocatalyst is employed as a representative research object and is thoroughly characterized by electrochemistry, electronic microscope as well as multiple spectroscopic analyses. Notably, BiVO4 coupling with Co−Co PBA cocatalyst could capture more photons than that of pure BiVO4, facilitating the transfer of photogenerated charge carriers between BiVO4 and Co−Co PBA as well as the surface catalytic efficiency of BiVO4. Overall, this work would promote the synthesis strategy development for exploring new types of composite photocatalysts for water oxidation.
Unravelling Enzymatic Features in a Supramolecular Iridium Catalyst by Computational Calculations
Authors: Tomasini Michele , Caporaso Lucia , Trouvé Jonathan , Poater Jordi , Gramage‐Doria Rafael , Poater Albert 
Published: July 2022

AbstractNon‐biological catalysts following the governing principles of enzymes are attractive systems to disclose unprecedented reactivities. Most of those existing catalysts feature an adaptable molecular recognition site for substrate binding that are prone to undergo conformational selection pathways. Herein, we present a non‐biological catalyst that is able to bind substrates via the induced fit model according to in‐depth computational calculations. The system, which is constituted by an inflexible substrate‐recognition site derived from a zinc‐porphyrin in the second coordination sphere, features destabilization of ground states as well as stabilization of transition states for the relevant iridium‐catalyzed C−H bond borylation of pyridine. In addition, this catalyst appears to be most suited to tightly bind the transition state rather than the substrate. Besides these features, which are reminiscent of the action modes of enzymes, new elementary catalytic steps (i. e. C−B bond formation and catalyst regeneration) have been disclosed owing to the unique distortions encountered in the different intermediates and transition states.
Evolving therapeutic strategies for patients hospitalized with new or worsening heart failure across the spectrum of left ventricular ejection fraction
Authors: Ostrominski John W. , Vaduganathan Muthiah 
Published: July 2022

AbstractHeart failure (HF) is a chronic, progressive, and increasingly prevalent syndrome characterized by stepwise declines in health status and residual lifespan. Despite significant advancements in both pharmacologic and nonpharmacologic management approaches for chronic HF, the burden of HF hospitalization—whether attributable to new‐onset (de novo) HF or worsening of established HF—remains high and contributes to excess HF‐related morbidity, mortality, and healthcare expenditures. Owing to a paucity of evidence to guide tailored interventions in this heterogeneous group, management of acute HF events remains largely subject to clinician discretion, relying principally on alleviation of clinical congestion, as‐needed correction of hemodynamic perturbations, and concomitant reversal of underlying trigger(s). Following acute stabilization, the subsequent phase of care primarily involves interventions known to improve long‐term outcomes and rehospitalization risk, including initiation and optimization of disease‐modifying pharmacotherapy, targeted use of adjunctive therapies, and attention to contributing comorbid conditions. However, even with current standards of care many patients experience recurrent HF hospitalization, or after admission incur worsening clinical trajectories. These patterns highlight a persistent unmet need for evidence‐based approaches to inform in‐hospital HF care and call for renewed focus on urgent implementation of interventions capable of ameliorating risk of worsening HF. In this review, we discuss key contemporary and emerging therapeutic strategies for patients hospitalized with de novo or worsening HF.
Performance of Afirma genomic sequencing classifier and histopathological outcome are associated with patterns of atypia in Bethesda category III thyroid nodules
Authors: Jin Xiaobing , Lew Madelyn , Pantanowitz Liron , Smola Brian , Jing Xin 
Published: July 2022

Background:Data on Afirma’s genomic sequencing classifier (GSC) performance in atypia of undetermined significance (AUS) subcategories is limited. This study investigated GSC performance in AUS nodules with architectural atypia (AUS‐A), cytological atypia (AUS‐C), architectural and cytological atypia (AUS‐AC), and predominantly Hürthle cells (AUS‐HC).Methods:This study retrieved consecutive thyroid nodules having a recurrent cytologic diagnosis of AUS with qualifiers and a concurrent GSC diagnostic result. All nodules were followed by either surgical intervention or clinical and/or ultrasound monitoring (≥6 months). GSC benign call rate (BCR), rate of histology‐proven malignancy, and diagnostic parameters of GSC were calculated for individual AUS subcategories. Statistical analysis was performed using the Fisher exact test.Results:A total of 135 AUS nodules fulfilled inclusion criteria, including 79 AUS‐A, 9 AUS‐C, 29 AUS‐AC, and 18 AUS‐HC. BCR was 72.2%, 66.7%, 44.8%, and 77.8% in AUS‐A, AUS‐C, AUS‐AC, and AUS‐HC, respectively. AUS‐A showed a greater BCR than AUS‐AC (p < .05). All GSC‐benign nodules were considered benign on clinical or surgical follow‐up. Among GSC‐suspicious nodules, histology‐proven malignancies represented 4.5% of AUS‐A, 0% of AUS‐C, 56.3% of AUS‐AC, and 25.0% of AUS‐HC cases. AUS‐AC demonstrated a higher malignant rate compared with AUS‐A (p < .05). GSC offers 100% NPV and a wide range (5%–56%) of PPV across all AUS subcategories. AUS‐AC demonstrated a greater PPV compared with AUS‐A (p < .05).Conclusion:BCR of GSC and malignant rates associated with suspicious GSC may differ in various AUS subcategories. GSC‐suspicious nodules with both architectural and cytologic atypia are more likely to be malignant. These findings may improve clinical triage and/or management of patients with AUS thyroid nodules.
A Universal Multichannel Platform for Assembling Enzyme‐Based Boolean Logic Gates
Authors: Melman Yacob , Katz Evgeny , Smutok Oleh 
Published: July 2022

AbstractConcatenated enzyme‐based Boolean logic gates activated with 5 chemical input signals were analyzed with a smartphone photo camera. Simultaneous detection of 32 input combinations was conveniently performed using enzyme‐modified fiberglass sensing spots generating fluorescence with different intensities for the 0 and 1 binary outputs. The developed technology offers an easy readout method for multi‐channel logic systems.
Reporting on sustainable development: Configurational effects of top management team and corporate characteristics on environmental information disclosure
Authors: Wang Ge , Zhang Huijin , Zeng Saixing , Meng Xiaohua , Lin Han 
Published: July 2022

AbstractAlthough widely explored in many studies, how and why combined top management team (TMT) and corporate characteristics affect environmental information disclosures (EID) are still lacking clarity. This study uses both fuzzy‐set qualitative comparative analysis and necessary condition analysis to reconcile the inconclusive results concerning the configurational effects of these characteristics on EID and to validate the robustness. From a sample of listed construction engineering corporates during the 2014–2018 period, the high EID level is associated with several complex configurations that contain the core characteristics such as corporate ownership and size, whereas the low EID level is related to the configurations including TMT salary and corporate profitability. The findings support the four tenets of equifinality, asymmetry, complexity, and causal asymmetry in complexity theory. Our results capture the complex non‐linear effects of TMT and corporate characteristics and shed new light on environmental disclosure management for corporate sustainable development.
Continuous Room‐Temperature Hydrogen Release from Liquid Organic Carriers in a Photocatalytic Packed‐Bed Flow Reactor
Authors: Ibrahim Malek Y. S. , Bennett Jeffrey A. , Abolhasani Milad 
Published: July 2022

AbstractInvited for this month′s cover is the group of Prof. Dr. Milad Abolhasani at North Carolina State University. The image shows an energy‐efficient strategy for on‐site and room‐temperature hydrogen release from liquid organic hydrogen carriers. The Research Article itself is available at 10.1002/cssc.202200733.
Multiple reconfigurable intelligent surfaces assisted downlink NOMA system
Authors: Hemanta Kumar M. , Sharma Sanjeev , Deka Kuntal , Thottappan M. 
Published: July 2022

SummaryPaper has considered multiple reconfigurable intelligent surfaces (RISs) assisted downlink non‐orthogonal multiple accesses (NOMA) system, referred to as MR‐NOMA. Multiple RISs create a line‐of‐sight (LOS) channel between BS and users to improve network coverage, especially in high frequencies and severe path attenuation scenarios. In MR‐NOMA, all RISs are in series and activated simultaneously; therefore, multiplicative beamforming gain from the inter‐RIS channels is achieved. Bit error probability (BEP) under the Rician fading channel is derived and compared with simulation results. It is observed that BEP performance depends on the number of passive reflecting elements, Rician factor, and positions of RISs panels in the MR‐NOMA.
Pace and shape of senescence in three species of duckweed
Authors: Paiha Austin P. , Laird Robert A. 
Published: July 2022

AbstractSenescence is progressive bodily deterioration associated with declines in survival and fecundity in older age classes. There is great diversity in patterns of senescence across species, but these patterns can be difficult to compare formally due to variation in the absolute time scales in which species live and die: members of some species live for a matter of days, others for millennia. To address this issue, the “pace‐shape” approach was developed to decouple absolute time from analyses and instead standardize life history traits in terms of average life expectancy, facilitating intra‐ and interspecific comparisons. Here, we use this approach to distinguish the generic form of demographic trajectories (shape) from the time scale on which the trajectories occurred (pace) in three species of tiny, free‐floating aquatic plants known as duckweeds (Lemna gibba L., L. minor L., and L. turionifera Landolt), which have mean lifespans of less than a month under typical lab conditions, and exhibit age‐related declines in survivorship and reproduction. Using a randomized block design in which we tracked a final total of 430 individuals, we report differences in pace and shape among the three species. Specifically, the largest, least‐fecund, and typically longest‐lived species, L. gibba, tended to exhibit more rapid decreases in time‐standardized survivorship and fecundity compared with the other two species. This study emphasizes variation in aging patterns that can be found among plant species, including those in the same genus, and provides further validation for the utility of applying the pace and shape approach in interspecific comparisons.
Atrial fibrillation and risk of progressive heart failure in patients with preserved ejection fraction heart failure
Authors: Gierula John , Cole Charlotte A. , Drozd Michael , Lowry Judith E. , Straw Sam , Slater Thomas A. , Paton Maria F. , Byrom Rowenna J. , Garland Ellis , Halliday Georgia , Winsor Sarah , Lyall Gemma K. , Birch Karen , McGinlay Melanie , Sunley Emma , Grant Peter J. , Wessels David H. , Ketiar Elias M. , Witte Klaus K. , Cubbon Richard M. , Kearney Mark T. 
Published: July 2022

AbstractAimsUnderstanding of the pathophysiology of progressive heart failure (HF) in patients with heart failure with preserved ejection fraction (HFpEF) is incomplete. We sought to identify factors differentially associated with risk of progressive HF death and hospitalization in patients with HFpEF compared with patients with HF and reduced ejection fraction (HFrEF).Methods and resultsProspective cohort study of patients newly referred to secondary care with suspicion of HF, based on symptoms and signs of HF and elevated natriuretic peptides (NP), followed up for a minimum of 6 years. HFpEF and HFrEF were diagnosed according to the 2016 European Society of Cardiology guidelines. Of 960 patients referred, 467 had HFpEF (49%), 311 had HFrEF (32%), and 182 (19%) had neither. Atrial fibrillation (AF) was found in 37% of patients with HFpEF and 34% with HFrEF. During 6 years follow‐up, 19% of HFrEF and 14% of HFpEF patients were hospitalized or died due to progressive HF, hazard ratio (HR) 0.67 (95% CI: 0.47–0.96; P = 0.028). AF was the only marker that was differentially associated with progressive HF death or hospitalization in patients with HFpEF HR 2.58 (95% CI: 1.59–4.21; P < 0.001) versus HFrEF HR 1.11 (95% CI: 0.65–1.89; P = 0.7).ConclusionsDe novo patients diagnosed with HFrEF have greater risk of death or hospitalization due to progressive HF than patients with HFpEF. AF is associated with increased risk of progressive HF death or hospitalization in HFpEF but not HFrEF, raising the intriguing possibility that this may be a novel therapeutic target in this growing population.
Five year risk assessment and treatment patterns in patients with chronic thromboembolic pulmonary hypertension
Authors: Kjellström Barbro , Bouzina Habib , Björklund Erik , Beaudet Amélie , Edwards Susan C. , Hesselstrand Roger , Jansson Kjell , Nisell Magnus , Rådegran Göran , Sandqvist Anna , Wåhlander Håkan , Hjalmarsson Clara , Söderberg Stefan 
Published: July 2022

AbstractAimsRepeated risk assessments and treatment patterns over long time are sparsely studied in chronic thromboembolic pulmonary hypertension (CTEPH); thus, we aimed to investigate changes in risk status and treatment patterns in incident patients with CTEPH over a 5 year period.Methods and resultsDescriptive and explorative study including 311 patients diagnosed with CTEPH 2008–2019 from the Swedish pulmonary hypertension registry, stratified by pulmonary endarterectomy surgery (PEA). Risk and PH‐specific treatment were assessed in surgically treated (PEA) and medically treated (non‐PEA) patients at diagnosis and up to 5 years follow‐up. Data are presented as median (Q1–Q3), count or per cent. Prior to surgery, 63% in the PEA‐group [n = 98, age 64 (51–71) years, 37% female] used PH‐specific treatment and 20, 69, and 10% were assessed as low, intermediate or high risk, respectively. After 1 year post‐surgery, 34% had no PH‐specific treatment or follow‐up visit registered despite being alive at 5 years. Of patients with a 5 year visit (n = 23), 46% were at low and 54% at intermediate risk, while 91% used PH‐specific treatment.In the non‐PEA group [n = 213, age 72 (65–77) years, 56% female], 28% were assessed as low, 61% as intermediate and 11% as high risk. All patients at high risk versus 50% at low risk used PH‐specific treatment. The 1 year mortality was 6%, while the risk was unchanged in 57% of the patients; 14% improved from intermediate to low risk, and 1% from high to low risk. At 5 years, 27% had a registered visit and 28% had died. Of patients with a 5 year visit (n = 58), 38% were at low, 59% at intermediate and 1% at high risk, and 86% used PH‐specific treatment.ConclusionsRisk status assessed pre‐surgery did not foresee long‐term post‐PEA risk and pre‐surgery PH‐specific treatment did not foresee long‐term post‐PEA treatment. Medically treated CTEPH patients tend to remain at the same risk over time, suggesting a need for improved treatment strategies in this group.
Expeditious Synthesis of a Glycopeptide Library
Authors: Ben Abba Amiel Dror , Hurevich Mattan 
Published: July 2022

AbstractShort proteoglycan fragments are of great importance for biochemical research. The solid‐phase synthesis of such glycopeptides relies on excessive use of glycosylated amino acids, extended reaction times, and additional post‐assembly deprotection protocols. We employed high‐shear mixing for expedient and equimolar O‐glycopeptide assembly. We further developed a stirring‐based deprotection on the solid support, thus completing the synthesis of a glycopeptide library in a minimal amount of time and purification hurdles.
Palladium‐Catalyzed Carbonylation of Allylic Chlorides to β,γ‐Unsaturated Esters/Amides under Mild Conditions
Authors: Wang Peng , Cao Zhusong . , Wang Yaxin X. , Neumann Helfried , Beller Matthias 
Published: July 2022

AbstractImproved procedures for carbonylative transformations (alkoxy‐ and aminocarbonylation) of cinnamyl chloride to synthesize β,γ‐unsaturated esters/amides have been developed. Studying critical reaction parameters (palladium precursors, solvents and bases) enabled the practical preparation of diverse β,γ‐unsaturated esters/amides under mild conditions (low Pd catalyst loading, phosphine‐free, 2 bar CO, 60 °C). The optimal catalytic system shows excellent chemo‐ and regioselectivity for the activation of the allylic C−Cl bonds.
Age and the relative importance of liver‐related deaths in nonalcoholic fatty liver disease
Authors: Lin Huapeng , Yip Terry Cheuk‐Fung , Zhang Xinrong , Li Guanlin , Tse Yee‐Kit , Hui Vicki Wing‐Ki , Liang Lilian Yan , Lai Jimmy Che‐To , Chan Stephen Lam , Chan Henry Lik‐Yuen , Wong Grace Lai‐Hung , Wong Vincent Wai‐Sun 
Published: July 2022

Background and Aims:
It is unclear if the leading causes of death in patients with NAFLD differ by age. We aimed to investigate if the relative importance of liver‐related deaths is lower and overshadowed by cardiovascular and cancer‐related deaths in the elderly population.

Approach and Results:
We conducted a territory‐wide retrospective cohort study of adult patients with NAFLD between 2000 and 2021 in Hong Kong. The outcomes of interest were all‐cause and cause‐specific mortality. Age groups at death were studied at 10‐year intervals. During 662,471 person‐years of follow‐up of 30,943 patients with NAFLD, there were 2097 deaths. The top three causes of death were pneumonia, extrahepatic cancer, and cardiovascular diseases. Liver disease was the sixth leading cause of death in patients aged 70–79 and 80–89 years, accounting for 5.1% and 5.9% of deaths, respectively, but only accounted for 3% or fewer of the deaths in the other age groups. Nonetheless, liver disease was the leading cause of death in patients with NAFLD‐related cirrhosis, accounting for 36.8% of all deaths. The incidence of liver‐related death was higher in men younger than age 70 but higher in women afterwards. The incidence of liver‐related death in women increased from 0.62 to 7.14 per 10,000 person‐years from age 60–69 to 70–79 years.

Conclusion:
The relative importance of liver‐related death increases with age in patients with NAFLD, especially among women. In patients with cirrhosis, liver disease is the leading cause of death.
An investigation of musculoskeletal discomforts among mining truck drivers with respect to human vibration and awkward body posture using random forest algorithm
Authors: Aliabadi Mohsen , Darvishi Ebrahim , Farhadian Maryam , Rahmani Ramin , Shafiee Motlagh Masoud , Mahdavi Neda 
Published: July 2022

AbstractUsing Random Forest algorithms, this study aimed to investigate musculoskeletal discomforts among mining truck drivers considering human vibration and awkward body posture. The study was conducted on 65 professional male drivers of mining trucks. The Cornell questionnaire was used to determine musculoskeletal discomforts. Drivers' exposure to vibrations was measured using the Svanteck 106 A vibration meter. The body posture was analyzed using the quick exposure check (QEC). The main mechanical and individual risk factors were used as predictor variables of musculoskeletal discomforts model. The relative importance of each feature on the discomforts was determined based on Random Forest algorithm compared with multiple linear regression using R Statistics Packages. The equivalent acceleration of whole‐body vibration (WBV) was higher than the exposure limit, however, the equivalent acceleration of hand‐transmitted vibration (HTV) was lower than the exposure limit. The body posture of drivers was from moderate to high risk so that investigation and changes are required soon. The predictive error of Random Forest model for musculoskeletal discomfort scores was at an acceptable level with root mean square error (RMSE) = 5.29 for the blind case of drivers compared with regressions model with RMSE = 15.92. Random forest showed that the awkward body posture, vibration, and age, respectively, have the greatest relative importance on musculoskeletal discomforts. The findings provide empirical evidence on the relative importance of risk factors on musculoskeletal discomfort so that awkward body posture has a greater effect compared with whole‐body vibration. Random forest provided better outputs and was more accurate compared with the regression method.