bluuebunny/crossref_metadata_2025_split huggingface dataset:
The early impacts of COVID-19 on people living with dementia: Part I of a mixed-methods systematic review
Authors: Giebel Clarissa , Lion Katarzyna , Lorenz-Dant Klara , Suarez-Gonzalez Aida , Talbot Catherine , Wharton Emily , Cannon Jacqueline , Tetlow Hilary , Thyrian Jochen Rene 
Published: February 2022

Abstract
Objectives

The aim of this Part I systematic review was to understand the impact of the COVID-19 pandemic on the lives of people with dementia living either in the community or in residential care.
Methods

This review was registered on PROSPERO [CRD42021248050]. Five data bases (PubMed, CINAHL, Embase, Scopus, Web of Science) were searched in July 2021. Studies were included if they reported on the impacts of the pandemic on people living with dementia, either in the community or residential settings, and published in English, German, Polish, or Spanish. Risk of bias was assessed using the Standard Quality Assessment QualSyst.
Results

Forty papers from 33 studies reported on the effects of COVID-19 on people with dementia. Included studies were conducted across 15 countries, focusing on single-country evaluations except in one study. Three studies focused on people with dementia residing in care homes, whilst the remainder reported on those in the community. Studies were categorised into five impacts: Cognition; Independence and physical functioning; Behavioural symptoms; Well-being; and Access to care. All studies reported on the negative impacts of the pandemic on various aspects of people with dementia’s lives, including faster cognitive, physical, and behavioural deterioration, limited access to care, and poorer mental and social health.
Conclusions

Future restrictions need to consider the need for people with dementia to stay cognitively, physically, and socially stimulated to live well. Longitudinal research is required on the long-term impacts of the pandemic on the lives of people with dementia, including time to care home entry.
Preliminary investigations into the utilization of lipase cross-linked enzyme aggregates (CLEA) in the hydrolysis of lipid-rich wastewater
Authors: Ayinla Adenike Zainab , Ademakinwa Adedeji Nelson , Agboola Femi Kayode 
Published: February 2022

Abstract
This study utilized Rhizopus oryzae lipase (RoL) as a potential biocatalyst in the hydrolysis of oil-contaminated wastewater. Immobilization of the RoL occurred via the preparation of cross-linked enzyme aggregates of the RoL using ammonium sulphate (50% w/v) and glutaraldehyde (0.125% v/v) as the precipitant and cross-linker respectively. Characterization of the RoL-CLEA was carried out using scanning electron microscopy. Prior to the enzymatic treatment of the wastewater, the lipid concentration and the chemical oxygen demand levels were determined. The RoL-CLEA could be reused up to five cycles and its catalysis increased free fatty acid levels in the wastewater by 84.8% and 142.1% at 0.5% and 1% (w/v) CLEA respectively. There was an increase in chemical oxygen demand (COD) removal by 7.6% and 29.5% from the oil-contaminated wastewater when 0.5% (w/v) and 1% (w/v) of the immobilized biocatalyst was used. In conclusion, the RoL CLEA is a unique biocatalyst in the treatment of oil-contaminated wastewater. Hence, there is the possibility of utilizing this biocatalyst for the large-scale remediation of oil-contaminated water bodies.
Pressure Sensitivity Improvement of Fiber Bragg Grating Sensor Using Cytop Fiber
Authors: Alshaikhli Zahraa , Alhasan Sarmad. F. H. , Khalid Farah G. , Salim Evan. T. 
Published: February 2022

Abstract
Recent demand for using FBG as a pressure sensor in a different industrial application makes several types of research to be conducted to enhance the pressure sensitivity. This paper demonstrates a combination method to enhance pressure sensitivity. Firstly, in this work FBG with polymer fiber named perfluorinated monomer (CYTOP) was used with specific parameters. Secondly, this FBG was covered by a patch of thin polymer material. However, the strain, temperature, and pressure sensitivity were recorded and compared with bare silica FBG. The temperature effect was reduced by using the cascade FBG technique. By applying force on the grating and changing of refractive index; the Bragg wavelength was shifting, making the CYTOP FBG responds more efficiently than silica FBG. This responsivity was leading to an improvement in pressure sensitivity. Experimental results illustrate that the enhanced CYTOP FBG based pressure sensor achieves pressure sensitivity up to 93.5 pm/KPs with a resolution of 0.005 KPa, which was 1500 times higher than bare FBG. The advanced CYTOP FBG based pressure sensor can be functionalized in a technical application for instance, structural health monitoring, pressure of oil wells application, explosion wave, and prevention of erosion.
Biodegradable and Biocompatible Subcutaneous Implants Consisted of pH-sensitive Mebendazole-Loaded/Folic acid-targeted Chitosan Nanoparticles for Murine Triple-Negative Breast Cancer Treatment
Authors: Kefayat Amirhosein , Hosseini Maryam , Ghahremani Fatemeh , Jolfaie Nafise Arbab , rafienia mohammad 
Published: February 2022

Abstract
Background
Mebendazole (MBZ) is a well-known anti-parasite drug with significant anti-cancer properties. However, MBZ exhibits low solubility, limited absorption efficacy, extensive first-pass effect, and low bioavailability. Therefore, multiple oral administration of high dose MBZ is required daily for achieving the therapeutic serum level which can cause severe side effects and patients’ non-compliance.
Method
In the present study, MBZ-loaded/folic acid-targeted chitosan nanoparticles (CS-FA-MBZ) were synthesized, characterized, and used to form cylindrical subcutaneous implants for 4T1 triple-negative breast tumor (TNBC) treatment in BALB/c mice. The therapeutic efficacy of the CS-FA-MBZ implants was investigated after subcutaneous implantation in comparison with Control, MBZ (40 mg/kg, oral administration, twice a week for 2 weeks), and CS-FA implants, according to 4T1 tumors’ growth progression, metastasis, and tumor-bearing mice survival time. Also, their biocompatibility was evaluated by blood biochemical analyzes and histopathological investigation of vital organs.
Results
The CS-FA-MBZ implants were completely degraded 15 days after implantation and caused about 73.3%, 46.5%, 37.3% decrease in the mean tumors’ volume in comparison with the Control (1050.5±120.7 mm3), MBZ (561.7±70.3 mm3), and CS-FA (658.3±88.1 mm3) groups, respectively. Average liver metastatic colonies’ number per microscope field at the CS-FA-MBZ (8.6±1.9) group was significantly (P<0.05) lower than the Control (24.5±4.1), MBZ (14.1±2.5), and CS-FA (15.7±3.1) groups. In addition, the CS-FA-MBZ treated mice exhibited about 51%, 24%, and 17% more survival time (days) after the cancer cells injection in comparison with the Control, MBZ, and CS-FA groups, respectively. Moreover, the CS-FA-MBZ implants were completely biocompatible based on histopathology and blood biochemical analyzes.
Conclusion
Taking together, CS-FA-MBZ implants were completely biodegradable and biocompatible with high therapeutic efficacy in a murine TNBC model.
Shedding Light On An Undiscovered Aspect That Perfectly Mimics Cosmic Acceleration
Authors: Takkhi Karan R. 
Published: February 2022

Abstract
The comparison of redshift-distance relationship for high and low-redshift supernovae revealed the surprising transition of the Universe’s expansion from deceleration to acceleration. As compared to local supernovae, remote supernovae appear 10% to 25% dimmer as they are further away than expected. The expansion rate obtained for local supernovae is higher with low redshifts as compared to the expansion rate obtained for remote supernovae with high redshifts. Since observed redshifts in an expanding Universe provide an estimate of recession velocities, therefore, it is very disturbing to find that low recession velocities (just 1% of speed of light) indicate a faster rate of expansion (acceleration), whereas high recession velocities (60% of speed of light) indicate a slower rate of expansion (deceleration). In this paper, I unravel an undiscovered aspect that perfectly mimics cosmic acceleration. Rather than “cosmic deceleration that preceded the current epoch of cosmic acceleration”, I show in this paper, that “consecutive expansion epochs of the Universe that preceded the current epoch of cosmic expansion” were responsible for placing remote supernovae further away than expected. As a consequence of consecutive expansion, expansion began for remote structures in preceding expansion epochs before it did for local structures in the current (or more recent) expansion epoch; remote supernovae, quasars, and gamma-ray bursts are therefore not only further away than expected, but they also happen to yield a slower rate of expansion, thereby suggesting their deceleration even with “superluminal expansion”. As a result of consecutive expansion, preceding expansion epochs appear to be decelerating as compared to the expansion epoch that succeeds them. The analysis is based on the redshift-distance relationship plotted for 580 type Ia supernovae from the Supernova Cosmology Project, 7 additional high-redshift type Ia supernovae discovered through the Advanced Camera for Surveys on the Hubble Space Telescope from the Great Observatories Origins Deep Survey Treasury program, and 1 additional very high-redshift type Ia supernova discovered with Wide Field and Planetary Camera 2 on the Hubble Space Telescope. The results obtained by the High-Z Supernova Search Team through observations of type Ia supernovae have also been analysed. Studies incorporating quasars and gamma-ray bursts to determine how the expansion of the Universe has changed over time have been taken into consideration as well. The results obtained in this paper have been confirmed by plotting velocity-distance relationship, expansion rate vs. time relationship, expansion factor vs. time relationship, scale factor vs. time relationship, scale factor vs. distance relationship, distance-redshift relationship, distance modulus vs. redshift relationship, and Hubble residuals, moreover, the deceleration parameter (q0) is also found to be negative (q0 < 0).
Evaluation of multisource precipitation input for hydrological modeling in an Alpine basin: a case study from the Yellow River Source Region (China)
Authors: Gu Pengfei , Wang Gaoxu , Liu Guodong , Wu Yongxiang , Liu Hongwei , Jiang Xi , Liu Tao 
Published: February 2022

Abstract
Alpine basins are typically poorly gauged and inaccessible owing to the harsh prevailing environment and complex terrain. In this study, two representative satellite precipitation products (Tropical Rainfall Measuring Mission (TRMM) Multi-satellite Precipitation Analysis (TMPA) 3B42RTV7 and Integrated Multi-Satellite Retrievals for GPM (IMERG) Final Run Version 06) and two reanalysis precipitation products (China Meteorological Assimilation Driving Datasets for the SWAT model (CMADS) and Climate Forecast System Reanalysis (CFSR)) in the Yellow River Source Region (YRSR) were selected for evaluation and hydrological verification against gauge-observed data (GO). Results show that the accuracy of these precipitation products in the warm season is higher than that in the cold season, and IMERG exhibits the best performance, followed by the CMADS, CFSR, and 3B42RTV7. Models that use the GO as input yielded satisfactory performance during 2008–2013, and precipitation products have poor simulation results. Although the model using the IMERG as input yielded unsatisfactory performance during 2014–2016, this did not affect the use of the IMERG as a potential data source for the YRSR. The model driven by the combination of GO and CMADS precipitation performed the best in all scenarios (R2=0.77, Nash–Sutcliffe efficiency (NSE)=0.72 at the Tangnaihai station; R2=0.53, NSE=0.48 at the Jimai station).
River water treatment by continuous electrocoagulation: insights into removal of acetaminophen, and natural organic matter
Authors: Kumari Shweta , Kumar R. Naresh 
Published: February 2022

Abstract
River water was treated by continuous electrocoagulation (EC) for acetaminophen (AP), natural organic matter (NOM measured as UV254), and removal of elements. HRT at 40 min with 0.5 mg/L AP exhibited the best removal efficiency for NOM (55.9%) and AP (53.4%) removal. Except for aluminium, other elements in river water were removed completely. The EC sludge (floating and settled) XRD spectrum showed peaks from AP were reduced, and the few peaks left were from aluminium hydroxide formed by EC. Several bonds in functional groups of AP and NOM were significantly deformed. FESEM images revealed that the sludge was highly porous material as needed for adsorption. EDAX showed that floating sludge had slightly higher carbon compared with settled sludge whereas nitrogen was higher in settled sludge. Other element concentrations in both sludges were similar, proving that water treatment was due to electro-floatation, adsorption, and sweep flocs. Single-factor ANOVA showed significant variance at HRT for NOM (F4.066 = 92.67, p = &lt;0.05) and AP (F4.066 = 20.59, p = &lt;0.05) removal. Variance was significant between treatments at different drug concentrations for NOM (F3.478 = 88.53, p = &lt;0.05) and AP (F3.478 = 529.85, p = &lt;0.05) removal. NOM removal correlated well with AP removal during continuous electrocoagulation.
Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to
Increase CNS Drug Delivery: Reality Versus Wishful Thinking?
Authors: Smith-Cohn Matthew A. , Burley Nicholas B. , Grossman Stuart A. 
Published: February 2022

Background:
The blood-brain barrier inhibits the central nervous system penetration of 98% of small molecule drugs and virtually all biologic agents, which has limited progress in the treatment of neurologic disease. Vasoactive peptides have been shown in animal studies to transiently disrupt the blood-brain barrier and regadenoson is currently being studied in humans to determine if it can improve drug delivery to the brain. However, there are many other vasoactive peptides that could potentially be used for this purpose.

Methods:
We performed a review of the literature evaluating the physiologic effects of vasoactive peptides on the vasculature of the brain and systemic organs. To assess the likelihood that a vasoactive peptide might transiently disrupt the blood-brain barrier, we devised a four-tier classification system to organize the evidence available.

Results:
We identified 33 vasoactive peptides with potential blood-brain barrier permeability-altering properties. To date, none of these are shown to open the blood-brain barrier in humans. 12 vasoactive peptides increased blood-brain barrier permeability in rodents. The remaining 23 had favorable physiologic effects on blood vessels but lacked specific information on permeability changes to the blood-brain barrier.

Conclusion:
Vasoactive peptides remain an understudied class of drugs with the potential to increase drug delivery and improve treatment in patients with brain tumors and other neurologic diseases. Dozens of vasoactive peptides have yet to be formally evaluated for this important clinical effect. This narrative review summarizes the available data on vasoactive peptides, highlighting agents that deserve further in vitro and in vivo investigations.
Survey on Structural Neuro Imaging for the Identification of Brain
Abnormalities in Schizophrenia
Authors: Prabha S. , Swathi N. 
Published: February 2022

Background:
The importance of identifying the structural and functional abnormalities in
the brain in the early prediction and diagnosis of schizophrenia has attracted the attention of neuroimaging
scientists and clinicians.

Objective:
The purpose of this study is to structure a review paper that recognizes specific biomarkers
of the schizophrenic brain.

Method:
Neuroimaging can be used to characterize brain structure, function, and chemistry by different
non-invasive techniques such as computed tomography, magnetic resonance imaging, magnetic
resonance spectroscopy, and positron emission tomography. The abnormalities in the brain can be used
to discriminate psychic disorder like schizophrenia from others. To find disease-related brain alterations
in neuroimaging, structural neuroimaging studies provide the most consistent evidence in most of
the studies.
The review discusses the major issues and findings in structural neuroimaging studies of schizophrenia.
In particular, the data is collected from different papers that concentrated on the brain affected
regions of different subjects and made a conclusion out of it.

Result:
In this work, a detailed survey has been done to find structural abnormalities in the brain from
different neuroimaging techniques. Several image processing methods are used to acquire brain images.
Different Machine learning techniques, Optimization methods, and Pattern recognition methods are
used to predict the disease with specific biomarkers, and their results are emphasized. Thus, in this
work, deep learning is also highlighted, which shows a promising role in obtaining neuroimaging data
to characterize disease-related alterations in brain structure.
INTERAÇÕES ENTRE COMPORTAMENTOS DE CIDADANIA ORGANIZACIONAL, SUPORTE SOCIAL E CONFIANÇA INTERPESSOAL NO SETOR DE TI
Authors: Costa Gabrielle Loureiro de Ávila , Estivalete Vania de Fátima Barros , Malheiros Michel Barboza , Andrade Taís de 
Published: February 2022

Objetivo: Identificar as interações existentes entre os Comportamentos de Cidadania Organizacional (CCO), Suporte Social no Trabalho (SST) e Confiança Interpessoal (CI).
Método/abordagem: Este estudo adota a abordagem quantitativa e descritiva, com adoção de uma estratégia survey. Para a coleta de dados foi estruturado um questionário baseado nos modelos de Comportamento de Cidadania Organizacional, de Dekas et al. (2013), de Suporte Social no Trabalho segundo Siqueira e Gomide Jr (2008) de Confiança Interpessoal, conforme Nyham (2000) e Oh e Park (2011). A pesquisa envolveu 352 indivíduos, de 41 empresas de Tecnologia da Informação (TI) no Brasil, sendo a maioria do Rio Grande do Sul.
Principais resultados: Os resultados demonstram a existência de relações positivas entre os três construtos (CCO, SST e CI). Sendo que para os trabalhadores da área de TI os comportamentos de Ajuda são os mais praticados, o Suporte Instrumental é o mais priorizado e a percepção de confiança ocorre mais frequentemente entre o superior e subordinado.
Originalidade/relevância: O estudo apresenta um avanço teórico-empírico, por abordar os temas e suas relações de forma conjunta, principalmente no que se refere à área de TI, o que contribui para o desenvolvimento teórico dos construtos trabalhados.
Peningkatan Kualitas Jaringan 4G LTE Menggunakan Metode Optimasi Teknik Traffic Sharing
Authors: Septiawan Dwi , Syamsuar Dedy 
Published: February 2022

Abstrak:Abstrak:Penelitian ini bertujuan untuk melakuan optimalisasi kualitas layanan dari jaringan 4G Long Term Solution (LTE). Kualitas suatu jaringan Telekomunikasi mejadi hal yang penting dalam dunia seluler. Gangguan kualitas jaringan akan menurunkan kepercayaan dari pihak pengguna yang selanjutnya memperngaruhi kepercayaan pengguna terhadap produk yang ditawarkan. Kualitas ini dipengaruhi oleh beberapa paramenter seperti Traffic, Throughput, Service drop rate (SDR), Handover success rate (HOSR), Radio resource control (RRC). Traffic sharing digunakan untuk mengoptimalkan kualitas jaringan dalam upaya mengoptimalkan beban busy hour traffic dalam satu cell E node B ke E node B lain yang memiliki beban traffic yang lebih rendah. Penelitian ini melakukan pendekatan trigonometri untuk menghasilkan rekomendasi traffic sharing pada jarak terdekat, jarak ideal maupun jarak terjauh dilokasi penelitian. Penelitian ini menghasilkan beberapa temuan setelah melakukan pendekatan traffic sharing di implementasikan. Pertama, adanya peningkatan kualitas throughput akibat distribusi trafik yang lebih baik. Kedua penurunan service drop rate dalam upaya mengurangi kegagalan pengguna pada saat menggunakan data 4G LTE. Ketiga meningkatkan keberhasilan pendudukan kanal Radio resource control (RRC) tanpa adanya penolakan dari masing – masing E node B dilokasi penelitian. Keempat menjaga keberhasilan perpindahan antar E node B Handover success rate (HOSR). Kelima untuk metode pendekatan trigonometri dapat menghasilkan pemetaan distribusi traffic maupun jarak yang lebih optimal.
Pengaruh Disiplin Kerja Dan Stres Kerja Terhadap Kinerja Karyawan di PT. Sankei Gohsyu Industries (Departemen Press Forging 1)
Authors: Karyono Karyono 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui untuk mengetahui pengaruh disiplin kerja terhadap kinerja, pengaruh stres kerja terhadap kinerja karyawan dan mengetahui pengaruh disiplin kerja dan stres kerja secara simultan terhadap kinerja karyawan PT Sankei Gohsyu Industries. Jenis penelitian yang digunakan adalah kuantitatif. Populasi dalam penelitian ini berjumlah 89 orang. Sampel yang digunakan sebanyak 89 responden di PT Sankei Gohsyu Industries dengan metode sampling jenuh. Metode pengumpulan data yang digunakan adalah kuesioner sebagai alat pengumpul data utama. Data dianalisis dengan regresi linear berganda dengan bantuan software SPSS versi 22. Hasil penelitian menunjukkan bahwa disiplin kerja (X1) berpengaruh signifikan secara parsial terhadap kinerja karyawan (Y). Nilai t hitung positif, artinya semakin meningkat disiplin kerja maka semakin meningkat pula kinerja karyawan, variabel stres kerja (X2) tidak berpengaruh signifikan secara parsial terhadap kinerja karyawan (Y) dan disiplin kerja (X1) dan stres kerja (X2) secara bersama – sama berpengaruh signifikan terhadap kinerja karyawan (Y) namun nilai interprestasi koefisiennya tergolong sangat rendah yaitu 17,0%. Oleh karena itu, untuk meningkatkan kinerja karyawan diperlukan diperhatikan disiplin kerja, karena variabel disiplin kerja (X1) adalah variabel yang berpengaruh paling dominan terhadap variabel kinerja (Y).