bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE
Authors: Huang Jingyu , Zhou Xuefeng , Li Changsheng , Tang Hexiao , Yang Zetian , Tang Zheng , Cheng Nitao 
Published: August 2022

Background:
The fatality rate of acute lung injury (ALI) is as high as 40% to 60%. Although
various factors, such as sepsis, trauma, pneumonia, burns, blood transfusion, cardiopulmonary
bypass, and pancreatitis, can induce ALI, patients with these risk factors will eventually develop ALI.
The rate of developing ALI is not high, and the outcomes of ALI patients vary, indicating that it is related
to genetic differences between individuals. In a previous study, we found multiple functions of
cavin-2 in lung function. In addition, many other studies have revealed that CAV1 is a critical regulator
of lung injury. Due to the strong relationship between cavin-2 and CAV1, we suspect that cavin-2
is also associated with ALI. Furthermore, we are curious about the role of the CAV family and cavin
family genes in ALI.

Methods:
To reveal the mechanism of CAV and CAVIN family genes in ALI, we propose
DeepGENE to predict whether CAV and CAVIN family genes are associated with ALI. This method
constructs a gene interaction network and extracts gene expression in 84 tissues. We divided these features
into two groups and used two network encoders to encode and learn the features.

Results:
Compared with DNN, GBDT, RF and KNN, the AUC of DeepGENE increased by 7.89%,
16.84%, 20.19% and 32.01%, respectively. The AUPR scores increased by 8.05%, 15.58%, 22.56%
and 23.34%. DeepGENE shows that CAVIN-1, CAVIN-2, CAVIN-3 and CAV2 are related to ALI.

Conclusion:
DeepGENE is a reliable method for identifying acute lung injury-related genes. Multiple
CAV and CAVIN family genes are associated with acute lung injury-related genes through multiple
pathways and gene functions.
Caffeic Acid Phenethyl Ester (CAPE) Attenuates Paclitaxel-induced
Peripheral Neuropathy: A Mechanistic Study
Authors: Sharma Shyam Sunder , Kulkarni Namrata Pramod , Vaidya Bhupesh , Narula Acharan S. 
Published: August 2022

Background:
Chemotherapy-induced peripheral neuropathy is a debilitating pain syndrome produced as a side effect of antineoplastic drugs like paclitaxel. Despite efforts, the currently available therapeutics suffer from serious drawbacks like unwanted side effects, poor efficacy and provide only symptomatic relief. Hence, there is a need to find new therapeutic alternatives for the treatment of Chemotherapy-induced peripheral neuropathy.

Objective:
The objective of this study was to explore the protective potential of Caffeic acid phenethyl ester in paclitaxel-induced neuropathic pain.

Methods:
We examined the effects of Caffeic acid phenethyl ester by administering Paclitaxel (2 mg/kg, intraperitoneal) to female Sprague Dawley rats on four alternate days to induce neuropathic pain, followed by the administration of Caffeic acid phenethyl ester (10 and 30 mg/kg, intraperitoneally).

Results:
Rats that were administered paclitaxel showed a substantially diminished pain threshold and nerve functions after 28 days. A significantly increased protein expression of Wnt signalling protein (β-catenin), inflammatory marker (matrix metalloproteinase 2) and a decrease in endogenous antioxidant (nuclear factor erythroid 2–related factor 2) levels were found in paclitaxel administered rats in comparison to the naïve control group. Caffeic acid phenethyl ester (10 and 30 mg/kg, intraperitoneal) showed improvements in behavioural and nerve function parameters along with reduced expression of β-catenin, matrix metalloproteinase 2 and an increase in NF-E2–related factor 2 protein expression.

Conclusions:
The present study suggests that Caffeic acid phenethyl ester attenuates chemotherapy-induced peripheral neuropathy via inhibition of β-catenin and matrix metalloproteinase 2 and increases nuclear factor erythroid 2–related factor 2 activation.
Microwave-assisted Synthesis of Pharmacologically Active 4-Phenoxyquinolines
and their Benzazole-quinoline Hybrids Through SNAr Reaction of
4,7-dichloroquinoline and Phenols Using [bmim][PF6] as a Green Solvent
Authors: Kouznetsov Vladimir V. , Rodríguez Enciso Duván A. , Puerto Galvis Carlos E. 
Published: August 2022

Background:
Quinoline and its derivatives have been shown to display a wide spectrum of biological properties, especially anticancer activity. Particularly, diverse potent anticancer drugs are based on the 4-phenoxyquinoline skeleton, acting as small-molecules VEGR2 and/or c-Met kinase inhibitors. However, the design of new drugs based on these quinoline derivatives remains a challenge. Up now, all approaches to 4-phenoxyquinoline skeleton construction do not obey any green chemistry principles.

Aim and Objective:
Developing a new, efficient protocol for the synthesis of potentially bioactive 4-phenoxyquinoline derivatives and benzazole-quinoline-quinoline hybrids from commercially available 4,7-dichloroquinoline and phenol derivatives using microwave energy (MW) in the presence of 1-methyl 3-butylimidazolium hexafluorophosphate.

Method:
New eco-efficient protocol for valuable 7-chloro-4-phenoxyquinolines and their hybrids, which is based on SNAr reaction of 4,7-dichloroquinoline with respective simple phenols and hydroxyaryl-benzazoles under MW energy in green reaction media, is studied for the first time. Results. We found that among various solvents tested, the ionic liquid 1-methyl 3-butylimidazolium hexafluorophosphate ([bmim][PF6]) favored the SNAr reaction affording phenoxyquinolines in excellent yields (72-82%) in 10 min. The developed protocol allowed to obtain quickly in good yields (48-60%) new diverse benzazole-quinoline hybrids, which are expected to be pharmacologically active. According to the calculated bioactivity scores, new hybrids are potential kinase inhibitors that could be useful in anticancer drug research.

Conclusion:
We developed for the first time a new green, efficient method to prepare potentially bioactive functionalized 7-chloro-4-phenoxyquinolines and benzazole-quinoline molecules. Good to excellent yields of the quinoline products, us MW irradiation in ([bmim][PF6] as a green solvent, and short times of reactions are some of the main advantages of this new protocol.
The Value of Thioredoxin Level and its Gene Polymorphism in the
Diagnosis of Post- HCV Hepatocellular Carcinoma
Authors: Abd-Elsalam Sherief , Alegaily Hatem Samir , Soliman Moataz Yousry , Gad Ahmed Mehrez , Abou-Omar Eid Abdel-Monsef , Saleh Mohamed , Abdellatif Raghda Samir , Fouad Amina , Azzam Omar Mahmoud , Abo-Amer Yousry Esam-Eldin 
Published: August 2022

Background:
Hepatocellular carcinoma (HCC) is one of the most common malignancies
and a leading cause of cancer-related death worldwide. Indeed, we need a novel tumor marker other
than AFP for early detection and to improve the outcome. Serum thioredoxin is a promising protein
involved in the pathogenesis of many malignancies. The study aims to evaluate serum thioredoxin
and its gene polymorphism in HCC in cirrhotic patients due to HCV infection.

Patients and Methods:
350 patients with HCC, 350 patients with chronic liver diseases, and 300
healthy controls were enrolled in our study. Serum thioredoxin level was measured by ELISA, and
molecular study of thioredoxin domain-containing 5 (TXNDC5) gene polymorphism (rs1225943)
polymorphism using real-time polymerase chain reaction by Taqman allele discrimination was done
for all subjects.

Results:
Our study revealed a significant increase in serum thioredoxin levels in patients with HCC
compared to chronic liver diseases and healthy controls. Using the Receiver operating characteristic
(ROC) curve at the area under the curve (AUC) 0.917 and a cut-off value of > 14.6 U/ml, our overall
sensitivity and specificity for the HCC group over the other groups were 86 % and 92.15%, respectively
with 92.2% positive predictive value and 54.9% negative predictive value. The molecular
study of TXNDC5 gene polymorphism (rs1225943) polymorphism revealed no significant difference
between the studied groups.

Conclusion:
Serum thioredoxin may be used as a promising tumor marker for HCC. Future research
is needed to assess its use as a single or combined with other markers in the diagnosis and follow-up
of the patients after interventions.
Febrile Seizures: An Updated Narrative Review for Pediatric Ambulatory
Care Providers
Authors: Leung James Sze-Chuck 
Published: August 2022

Background:
While generally self-limited, febrile seizures result in significant familial distress. Ambulatory pediatric care providers must be prepared to counsel families on the causes, risk factors, management principles, and prognosis of children with febrile seizures.

Objective:
To provide an updated, evidence-based review of febrile seizures focused on the needs of an ambulatory pediatric care provider.

Methods:
A narrative review of the literature prioritizing landmark articles, metanalyses, longitudinal population longitudinal cohort studies and national level guidelines.

Results:
Febrile seizures are aberrant physiological responses to fever in children caused by complex interactions of cytokine mediated neuroinflammation, environmental triggers, and genetic predisposition. Other than investigations to determine fever etiology, routine bloodwork, lumbar punctures, neuroimaging and electroencephalograms are low yield. The general prognosis is excellent, however, clinicians should be aware of long-term outcomes including: cognitive impairment with non-simple febrile seizures; neuropsychiatric associations; recurrent febrile seizure and epilepsy risk factors; and association between complex febrile seizures and sudden unexpected death. Children with high risk of recurrence, complex febrile seizures, limited access to care, or extreme parental anxiety may benefit from intermittent oral diazepam prophylaxis.

Conclusion:
Clinicians should consider four management priorities: 1) terminating the seizure; 2) excluding critical differential diagnoses; 3) investigating fever etiology; and 4) providing adequate counselling to families. The clinical approach and prognosis of febrile seizure can be based on subtype. Children with non-simple (i.e. complex or febrile status epilepticus) febrile seizures require closer care than the vast majority of children with simple febrile seizures, who have excellent outcomes.
A Systematic Literature Review of Injection Site Pain Perception in Adult
Patients Treated with Citrate-Free and Citrate-Containing Biologic Agents
Authors: Junker Sophia , Ebert Oliver , Bartsch Robert 
Published: August 2022

Objective:
To investigate injection site pain (ISP) and other injection site outcomes caused by biologics administered alongside citrate-free (CF) and citrate-containing (CC) formula-tions.

Methods:
Electronic literature databases (Medline, Embase, and Cochrane Library) were systemati-cally searched for clinical trials and observational studies reporting on injection site outcomes after subcutaneous administration of biologics. Studies with unknown excipient formulations were ex-cluded. The primary outcome was ISP, and secondary outcomes included any other reported injec-tion site reactions (ISRs). Meta-analysis approaches were used to aggregate evidence identified via the conducted systematic literature review.

Results:
A total of two observational studies, two cross-over/sequential trials, and three head-to-head comparison trials directly comparing CF with CC biologics were identified, as well as seven placebo-controlled trials. Evidence from five of the seven direct comparison studies suggested re-duced pain perception at the injection site when CF formulations were applied. Findings for other ISRs were balanced between both formulations, with slightly favorable results for preparations without citrate. A meta-analysis of placebo-controlled trials found no significant difference between arms with CF formulations and placebo regarding the proportion of patients experiencing ISP (OR 0.62, 95% CI 0.30-1.28).

Conclusion:
Excipient formulations are rarely specified in studies assessing pain and other ISRs of subcutaneously administered biologics. The available data indicate that subcutaneous administration of biologic agents without citrate may be associated with lower pain perception outcomes compared with treatment using CC formulations. Importantly, ISP is influenced by many factors which may have affected the results. More research is needed to assess how formulation excipients influence ISRs.
Translation and French Linguistic Validation of the Bath Ankylosing
Spondylitis Functional Index and the Bath Ankylosing Spondylitis Global
Score in Patients with Axial Spondyloarthritis
Authors: Soulard Julie , Vaillant Jacques , Baillet Athan , Vuillerme Nicolas 
Published: August 2022

Abstract:
Axial spondyloarthritis (axSpA) may lead to functional and physical dis-turbances. Self-administered questionnaires can measure functional limitations associated to axSpA. If these questionnaires are currently used in clinical practice and research, the French version of these questionnaires has not been validated. The aim of this study was to translate and perform a linguistic validation of the Bath Ankylosing Spondylitis Functional Index (BASFI) and the Bath Ankylosing Spondylitis Global score (BAS-G) in French.

Methods:
The study has been approved by local ethic committee and is registered in Clinical Trial (NCT04212806). The translation process was performed through a forward/backward validation process, followed by clinician experts validation and patient cognitive interviews.

Results:
The two questionnaires were translated into a French version by two independent transla-tors. Translators then agreed on sentences being different between the two translations. The back-ward translation was equivalent to the initial English version except for two questions. Five French clinician experts on rheumatology made essential changes in sentences constructions of the translat-ed questionnaire. The last version of the questionnaires was presented to 5 patients with axSpA which all found them clear and understandable.

Conclusion:
BASFI and BAS-G would be a generally reliable instrument for patients with axSpA. These questionnaires can be widely used in clinical practice and research in French-speaking popu-lation. The use of these questionnaires is expected to have a positive impact on patient care to better understand physical consequences of axSpA.
The Effect of Postbiotics On Depressive Symptoms and Polycystic Ovary
Syndrome (PCOS) in Human Health: A Short Review
Authors: Pirhadi Mohadeseh , Khaniki Gholamreza Jahed , Nejad Amir Sasan Mozaffari , Sadighara Parisa 
Published: August 2022

Abstract:
Postbiotics are known as preparations comprising inert microorganisms and/or their
ingredients that activate health profits on the host. They stimulate the intestine microbiome, support
gut immune activity, and prevent pathogenic microorganism duplication. Although postbiotics are a
type of probiotic waste, they can apply some beneficial effects on human health, such as antiobesity,
antioxidant, immunomodulatory, and anti-carcinogenic. Accordingly, many studies suggested
a conclusive effect of postbiotics on polycystic ovary syndrome (PCOS) in women and
depressive symptomatology. The aim of our study was to provide an updated review of these subjects.
We conducted a systematic search of the literature in multiple databases, such as Web of Science,
Google Scholar, Science Direct, and PubMed based on some keywords. In the current review,
we have focused on better understanding of postbiotics on consumers’ health providing a base for
future investigation.
Depression Screening Scores and Allergy and Gastrointestinal Medication
Use in Adolescents
Authors: Harris Kari , Saikumar Pavithra , Sunkoj Yojana , Vancuren Trista , Olufowote Blessing , Dedeaux Julian 
Published: August 2022

Introduction:
Between 2005 and 2014, the 12-month prevalence of major depressive
episodes among adolescents aged 12 to 17 years increased from 8.5% to 11.3%. Adolescent-onset
depression is related to increased risk for depression and suicidal attempts in adulthood. It is known
that depression is an adverse effect among adults taking OAM; however, the effect of OAM on adolescents
is unknown.

Aim:
The aim of this study was to describe the relationship between Patient Health Questionnaire 9-
Modified (PHQ9-M) scores and OAM use among adolescents.

Methods:
This study included data abstracted from charts of adolescents aged 12 to 21 years who
completed a Kansas Be Healthy wellness appointment at the KUSM-W Peds Clinic in 2017. Odds
ratios were used to calculate the relationship between oral allergy medication and gastrointestinal
medication use among adolescents and PHQ9-M scores.

Results:
Of the 425 adolescent charts analyzed, 22% (n=96) had positive PHQ9-M screens (a score of 10
or greater), and 13% (n=56) reported current use of allergy medication and/or GI medications. Adolescents
taking oral allergy medication were 1.77 times more likely to have a positive PHQ9-M screen than those not
taking oral allergy medication. Among adolescents on allergy medication, there was no difference in PHQ9-
M scores based on the drug class (1st or 2nd generation antihistamine or Montelukast).

Conclusion:
Healthcare providers must diligently explore OAM/GI use with adolescents during
clinical encounters and discuss possible adverse effects of OAM on mood.
Review of the Published Literature Confirms the Safety of Intravenous
Infusion of Mesenchymal Stem Cells
Authors: Barmada Amir , Sharan Joshua , Band Nicolas , Rumschlag Tobias , Yaqub Arwah , Liebman Eliana , Prodromos Chadwick 
Published: August 2022

Background:
Mesenchymal stem cells (MSCs) have been shown to decrease inflammation and
enhance healing due to their immunomodulatory properties and secretion of growth factors. Intravenous
infusion is the most common delivery route of MSCs, and it is used for the treatment of a wide variety of
conditions, with established efficacy.

Objective:
This review will analyze the safety of intravenous infusion of MSCs and determine the incidence
of any possible resultant Serious Adverse Events (SAEs).

Methods:
Using PubMed, we searched the scientific literature to identify SAEs related to intravenous
infusion of MSCs. We performed disease-specific searches and a general adverse event search.

Results:
A total of 70 studies were included in this review. Thousands of infusions were administered and
only two SAEs were identified from the same study. The SAEs were two upper extremity thromboembolisms
in patients with preexisting renal disease.

Conclusion:
Properly performed intravenous infusion of MSCs is very safe, with a near absence of reported
serious adverse events associated with its use.
Therapeutic Role of Phytophenol Gallic Acid for the Cure of COVID-19
Pathogenesis
Authors: Baraskar Kirti , Thakur Pratibha , Shrivastava Renu , Shrivastava Vinoy K. 
Published: August 2022

Abstract:
The SARS CoV-2 virus, the causative agent of COVID-19 uses the ACE-2 receptor of
the host to penetrate and infect the cell, mainly in the pulmonary, renal, and cardiac tissues. The
earlier reported Delta and the recent Omicron are the variants of concern. The mutations in the RBD
region of spike protein are associated with increased RBD-ACE-2 receptor interaction. This binding
affinity between spike protein and the receptor is greater in Omicron than in the Delta variant. Moreover,
the Omicron variant has numerous hydrophobic amino acids in the RBD region of the spike
protein, which maintain its structural integrity. Gallic acid is a phytophenol and shows high binding
affinity toward the ACE-2 receptors, which may be helpful for better outcomes in the treatment of
COVID-19 pathogenesis. In the present study, significant data were collected from different databases
i.e., PubMed, Scopus, Science Direct, and Web of Science by using keywords like anti-oxidative,
anti-inflammatory, and antimicrobial properties of gallic acid, in addition to receptor-based
host cell interaction of SARS CoV-2 virus. The finding shows that gallic acid can reduce inflammation
by attenuating NF-κB and MAPK signaling pathways to suppress the release of ICAM-1, a
cell surface glycoprotein; various pro-inflammatory cytokines like TNF-α, IL 1-β, IL-6, IL-10, and
chemokines like CCL-2,5, CXCL-8 along with tissue infiltration by immune cells. The purpose of
this review is to highlight the therapeutic potential of gallic acid in COVID-19 pathogenesis based
on its strong anti-oxidative, anti-inflammatory, and anti- microbial properties.
Review on Research Progress of Flexible Soft Manipulator
Authors: Tang Liqiang , Xie Baocheng 
Published: August 2022

Background:
Manipulator is widely used in the manufacturing industry because it can
imitate some movements of human hands, and replace human hands to complete some high-risk and
heavy labor or carry out man-machine cooperation. Flexible soft manipulator made of flexible materials
is a new field of the manipulator. Investigation of the material and driving mode of the flexible
soft manipulator is helpful to improve the flexibility and force position control when grasping objects.
Therefore, researchers pay more and more attention to the development trend of the flexible
soft manipulator.

Objective:
In order to optimize the driving mode and materials of a flexible soft manipulator, pneumatic-
driven flexible soft manipulator and variable stiffness flexible soft manipulator are developed.

Methods:
This paper summarizes the selection, classification and introduction of patents related to
pneumatic drive and variable stiffness in the flexible soft manipulator.

Results:
Through the investigation of various patents on flexible soft manipulators, the main existing
problems in flexible soft manipulators, such as small grasping range and insufficient driving
force, are summarized and analyzed. In addition, the development trend of flexible soft manipulators
is also discussed.

Conclusion:
The optimization of the driving mode and materials of the manipulator is beneficial to
improve the driving force and grasping force. More related patents will be invented in the future.
Emojis in Deceptive Online Communication: The Frequency and Type of Emoji in Deceptive and NonDeceptive Online Messages
Authors: Walther Michelle , Petrov Petar , Smith Ryan , Young Danielle , de Vries Peter W. , Stel Marielle 
Published: August 2022

Background:
Little research has been done on nonverbal deception cues in computer-mediated communication (CMC). However, deception is a daily occurrence and since much communication is shifting towards CMC, it is important to understand the difference between truthful and deceptive messages.

Objective:
This research obtained more insight in the use of emoji in deceptive messages by answering the question: Are the frequency and type of emoji different in deceptive compared to truthful online messages?

Methods:
Participants sent three screenshots of deceptive, and truthful messages to WhatsApp. The used emoji were counted and sorted into levels of valence (positive, negative, and neutral) and intensity (strong versus weak).

Results:
The results indicated that participants used more negative, weak emoji in deceptive compared with truthful messages and more positive, weak, and strong emoji in truth compared with deceit. No difference was found for the emoji frequency.

Discussion:
The results are discussed in the light of earlier research. However, this is the first study investigating the use of emoji in the context of computer-mediated deception.

Conclusion:
The type of emoji can be indicative of used as a nonverbal deception cue in online messages.