bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrahepatic hematoma secondary to transjugular intrahepatic portosystemic stent–shunt procedure: Case report and literature review
Authors: Cheng Ziyao , Ju Jiayu , Zhu Qingliang , Deng Mingming , Zhang Hailong 
Published: November 2022

Rationale:
Transjugular intrahepatic portosystemic stent–shunt (TIPSS) is a minimally invasive procedure used for the treatment of portal hypertension. Intrahepatic hematoma is the rare complication caused by hepatic arterial injuries from TIPSS procedure.

Patient concerns:
This case report illustrated a 77-year-old man with hepatitis B virus-induced cirrhosis who underwent TIPSS.

Diagnoses:
The patient suffered from intrahepatic hematoma and hepatic pseudoaneurysm because of the hepatic artery injury after TIPSS.

Interventions:
The hepatic artery laceration began at the level of the branch of the left hepatic artery was embolized.

Outcomes:
The acute intrahepatic hematoma and hepatic pseudoaneurysm of the patient were cured.

Conclusion:
In this report, we describe a cirrhosis patient with a large intrahepatic hematoma secondary to TIPSS, and a literature review is also presented. The intrahepatic hematoma and hepatic pseudoaneurysm should be paid more attention after TIPSS while early-stage prevention should be carried out.
Japanese pediatric patient with refractory steroid-resistant ulcerative colitis successfully treated with Tofacitinib: A case report
Authors: Kakiuchi Toshihiko , Yoshiura Masato 
Published: November 2022

Rationale:
Tofacitinib is an orally administered selective Janus kinase inhibitor. Its efficacy and safety in adults with moderately to severely active ulcerative colitis (UC) have been evaluated in clinical trials; however, its efficacy in pediatric patients with UC is limited.

Patient concerns:
A 9-years-old boy was referred to our hospital with chief complaints of diarrhea and bloody stool for 2 months. Colonoscopy revealed total colitis-type UC. His pediatric UC activity index score was 40, indicating moderately active UC.

Diagnosis:
UC.

Interventions:
Vedolizumab, golimumab, and ustekinumab were introduced because of steroid-resistant refractory UC; however, none of these biologics were effective or the effect was short-lived. Therefore, tofacitinib was administered 5 mg twice a day.

Outcomes:
The patient achieved UC remission after tofacitinib treatment, leading to maintained remission without adverse events.

Lessons:
To the best of our knowledge, this is the first pediatric case of moderately active UC that was successfully treated with tofacitinib in Japan. Tofacitinib is a safe drug for pediatric patients with moderately active UC. Even in steroid-dependent cases refractory to other biologics, tofacitinib can result in remission induction and maintenance effects. In children and adults, high-dose tofacitinib during induction therapy may be unnecessary to reduce adverse events.
Comparison arthroscopic reconstruction and percutaneous reconstruction of ankle lateral ligament for chronic ankle lateral instability: A protocol for a meta-analysis of comparative studies
Authors: Hou Huiming , Zhou Ming , Zhou Xing , Guo Wenxuan , Zhuang Rujie , Yin Hong , Li Jinlei 
Published: November 2022

Background:
Ankle sprains occur very frequently in daily life, but people who do not pay attention to them and do not receive proper diagnosis and treatment are very prone to develop chronic ankle lateral instability (CALI) at a later stage. For CALI where conservative treatment has failed, reconstruction of the lateral collateral ligament of the ankle can achieve satisfactory results, but there are various and controversial ways of ligament reconstruction. While percutaneous reconstruction of ankle lateral ligament (PLCLR) needs to be performed repeatedly under fluoroscopy, total arthroscopic reconstruction of ankle lateral ligament (ALCLR) is increasingly recognized by experts and scholars for its minimally invasive and precise characteristics, and has achieved good clinical results. Therefore, it is imperative that a meta-analysis be performed to provide evidence as to whether there is a difference between ALCLR and PLCLR in the treatment of CALI.

Methods:
We will search articles in 7 electronic databases including Chinese National Knowledge Infrastructure, Wanfang Data, Chinese Scientific Journals Database, Chinese databases SinoMed, PubMed, Embase, and Cochrane Library databases. All the publications, with no time restrictions, will be searched without any restriction of language and status, the time from the establishment of the database to September 2022.We will apply the risk-of-bias tool of the Cochrane Collaboration for Randomized Controlled Trials to assess the methodological quality. Risk-of-Bias Assessment Tool for Non-randomized Studies was used to evaluate the quality of comparative studies. Statistical analysis will be conducted using RevMan 5.4 software.

Results:
This systematic review will evaluate the functional outcomes and radiographic results of ALCLR in the treatment of CALI.

Conclusion:
The conclusion of this study will provide evidence for judging whether ALCLR is superior to PLCLR for treatment of CALI.

Trial registration number:
CRD42022362045.
A Phase II Study of Ziv-Aflibercept in Patients With Advanced Extrapancreatic Neuroendocrine Tumors
Authors: Perez Kimberly , Kulke Matthew H. , Horick Nora K. , Regan Eileen , Graham Christopher , Scheutz Samantha , Stonely Danielle , Enzinger Peter C. , Fuchs Charles S. , Allen Jill N. , Enzinger Andrea C. , Clark Jeffrey W. , Chan Jennifer A. 
Published: November 2022

Objectives
Neuroendocrine tumors (NETs) are characterized by their expression of vascular endothelial growth factor (VEGF). This trial investigated the activity of Ziv-aflibercept, a recombinant protein that binds to and inhibits the activity of VEGF, in patients with advanced NETs (NCT01782443).

Methods
A single-arm, phase II trial enrolling patients with advanced, progressive extrapancreatic NET. Patients were treated with Ziv-aflibercept 4 mg/kg intravenously on day 1 and 15 of a 28-day cycle; the starting dose was reduced to 2 mg/kg on days 1 and 15 of a 28-day cycle because of hypertension-related events. The primary end point was progression-free survival.

Results
The trial enrolled 19 patients (13 male:6 female). Patients received a median of 7 cycles (range, 1–18 cycles). The median progression free survival was 11.8 months (95% confidence interval, 3.2–16.1 months), and the median overall survival was 36.4 months (95% confidence interval, 16.1–not reached). Best responses by Response Evaluation Criteria in Solid Tumors 1.1 are as follows: 1 (5%) partial response, 13 (68%) stable disease, 2 (10%) with progressive disease, and 3 (15%) unevaluable. Hypertension occurred in 18 patients (95%), including grade 3–4 hypertension in 12 patients (63%).

Conclusions
Although the progression free survival is similar to other VEGF inhibitors in NET, toxicity may preclude further investigation.
Clinical Trials in Pancreatitis: Opportunities and Challenges in the Design and Conduct of Patient-Focused Clinical Trials in Recurrent Acute and Chronic Pancreatitis
Authors: Hart Phil A. , Andersen Dana K. , Lyons Erica , Cote Gregory A. , Cruz-Monserrate Zobeida , Dworkin Robert H. , Elmunzer B. Joseph , Fogel Evan L. , Forsmark Christopher E. , Gilron Ian , Golden Megan , Gozu Aysegul , McNair Lindsay , Pandol Stephen J. , Perito Emily R. , Phillips Anna Evans , Rabbitts Jennifer A. , Whitcomb David C. , Windsor John A. , Yadav Dhiraj , Palermo Tonya M. 
Published: November 2022

Abstract
Recurrent acute pancreatitis and chronic pancreatitis represent high morbidity diseases, which are frequently associated with chronic abdominal pain, pancreatic insufficiencies, and reduced quality of life. Currently, there are no therapies to reverse or delay disease progression, and clinical trials are needed to investigate potential interventions that would address this important gap. This conference report provides details regarding information shared during a National Institute of Diabetes and Digestive and Kidney Diseases–sponsored workshop on Clinical Trials in Pancreatitis that sought to clearly delineate the current gaps and opportunities related to the design and conduct of patient-focused trials in recurrent acute pancreatitis and chronic pancreatitis. Key stakeholders including representatives from patient advocacy organizations, physician investigators (including clinical trialists), the US Food and Drug Administration, and the National Institutes of Health convened to discuss challenges and opportunities with particular emphasis on lessons learned from trials in participants with other painful conditions, as well as the value of incorporating the patient perspective throughout all stages of trials.
Salivary Biomarker Evaluation of Chronic Pancreatitis Patients Reveals Alterations in Human Proteins, Cytokines, Prostaglandin E2 Levels, and Bacterial Diversity
Authors: Waldron Richard T. , Jones Elaina K. , Anani Vincent I. , Hines Jolaine M. , Zhao Jing , Lugea Aurelia , Diniz Marcio A. , Kim Sungjin , Habtezion Aida , Hoffman Kristi L. , Petrosino Joseph F. , Fisher William E. , Li Liang , Lennon Ryan J. , Singh Ravinder Jit , Vege Santhi Swaroop , Pandol Stephen J. , Topazian Mark D. 
Published: November 2022

Objectives
Chronic pancreatitis (CP) is a chronic fibroinflammatory condition of the pancreas difficult to diagnose in early stages. Novel biomarkers useful to facilitate early diagnosis or treatment responses may be found in biofluids. Although saliva can be easily and noninvasively collected from patients, useful salivary biomarkers from CP patients have not yet been identified.

Methods
Here, we analyzed the proteome by quantitative proteomics, cytokine/chemokine levels by Luminex analysis, prostaglandin E2 (PGE2) levels by a mass spectrometry-based assay, and bacterial species diversity by 16S ribosomal ribonucleic acid sequencing in saliva samples from confirmed CP patients and healthy controls.

Results
Our results indicate the presence of various differentially expressed proteins, cytokines/chemokines, and a loss of oral bacterial diversity in the saliva of CP patients. The PGE2 levels trend toward elevation in CP patients. Area under the receiver operating characteristic curve models for proteomic, cytokine, and PGE2 assays ranged from 0.59 to 0.90.

Conclusions
Collectively, our studies identify a range of putative CP biomarkers and alterations in human saliva requiring further validation. The biomarker discovery approaches we used might lead to identification of biomarkers useful for CP diagnosis and monitoring.
Open-Source Ultrasound Trainer for Healthcare Professionals
Authors: Morrison Ryan G. , Halpern Sophie A. , Brace Eamonn J. , Hall Arielle J. , Patel Dip V. , Yuh Jonathan Y. , Brolis Nils V. 
Published: November 2022

Introduction
This technical report describes the development of a high-fidelity, open-source ultrasound trainer and showcases its abilities through a proof-of-concept, pilot randomized control trial. The open-source ultrasound trainer (OSUT) aims to enhance anatomical visualization during ultrasound education. The OSUT can attach to any ultrasound transducer, uses minimal hardware, and is able to be used during live patient ultrasound examinations.

Methods
After viewing a standardized training video lecture, 24 incoming first-year medical students with no prior ultrasound experience were randomized into a control group given an ultrasound system or an intervention group given the OSUT in addition to an ultrasound system. Both groups were tasked with localizing the thyroid, abdominal aorta, and right kidney on a patient. Performance outcomes were structure localization time, ultrasound image accuracy, and preactivity and postactivity participant confidence.

Results
The OSUT decreased right kidney localization time (Kruskal-Wallis, P < 0.001), increased sonographer right kidney accuracy ratings (Mann-Whitney U, U = 10.5, P < 0.05), and increased confidence in structure identification (Mann-Whitney U, U = 37, P = 0.045) and overall ultrasound ability (Wilcoxon signed-rank test, P = 0.007). There was no significant change in localization time, accuracy ratings, or participant confidence for locating the thyroid and abdominal aorta.

Conclusions
A high-fidelity, open-source ultrasound trainer was developed to aid healthcare professionals in learning diagnostic ultrasound. The study demonstrated the potential beneficial effects of the OSUT in localizing the right kidney, showcasing its adaptability and accessibility for ultrasound education for certain anatomical structures.
Comparison Canal Filling Ratio And Femoral Bone Density Change Between Wedge Taper And Anatomical Stem Design
Authors: ploynumpon Patcharavit , Chompoosang Thakrit 
Published: November 2022

AbstractPurposecomparative the outcome of proximal femoral bone density change in follow-up x-ray film and proximal filling ratio of stem between anatomical and double taper wedge cementless stem designMethodspost-operative follow film of up to 1 year of patients who had undergone Total hip arthroplasty between 2552-2563, which is match inclusion criteria, was obtained from the radiology department. The measurement of Canal filling ratio (Lesser trochanter, 2 cm above LT and 7 cm below LT) and Femoral bone density change using optimal densitometry method to compare between Anatomical and double wedge taper stem type.Result92 patients,76% female, and 24% male, were match the inclusion criteria for this study. The mean age was 53.86±13.00 years old. The canal filling ratio in the double wedge taper group (Accolade II) was significantly higher than the anatomical stem group (ABGII) (p<0.001, p<0.001, p=0.013) in all levels of measurement. There were no significant differences between both types of the stem in femoral bone density change in zone 1,4. However. There were significant differences in femoral bone change, in which bone loss was higher in the anatomical stem group, in zone 7 (−25 VS −17, P= 0.010)ConclusionDouble taper wedge stem design had a significantly higher canal filling ratio than the Anatomical stem at all levels and less femoral bone density loss in follow-up post-operative film at Zone 7. However, in zone 1,4, There was no significant difference in femoral bone density loss.
Cerebrovascular damage caused by the gut microbe/host co-metabolitep-cresol sulfate is prevented by blockade of the EGF receptor
Authors: Shah Sita N. , Knausenberger Tobias B-A. , Pontifex Matthew G. , Connell Emily , Le Gall Gwénaëlle , Hardy Tom A. J. , Randall David W. , McCafferty Kieran , Yaqoob Muhammad M. , Solito Egle , Müller Michael , Stachulski Andrew V. , Glen Robert C. , Vauzour David , Hoyles Lesley , McArthur Simon 
Published: November 2022

AbstractCirculating levels of the gut microbe/host co-metabolite p-cresol sulfate (pCS) correlate with cerebrovascular event risk in individuals with chronic kidney disease, but whether this relationship is mechanistic is unclear. We hypothesised that pCS would impair function of the blood-brain barrier (BBB), the primary brain-vasculature interface. We report that pCS exposure impairs BBB integrity in human cellsin vitroand both acutely and chronically in mice, enhancing tracer extravasation, disrupting barrier-regulating tight junction components and ultimately affecting whole-brain transcriptomic activity.In vitroandin vivomechanistic studies showed that pCS activated epidermal growth factor receptor (EGFR) signalling, resulting in matrix metalloproteinase mobilisation and BBB damage. Furthermore, blockade of EGFR prevented the permeabilising effects of serum from haemodialysis patients upon cerebromicrovascular endotheliain vitro. Our results define a pathway linking the co- metabolite pCS with BBB damage and suggest targeting the EGFR may mitigate against cerebrovascular damage in CKD.
A Machine-Learning Approach for Predicting Depression Through Demographic and Socioeconomic Features
Authors: Sun Joseph , Liao Rory , Shalaginov Mikhail Y. , Zeng Tingying Helen 
Published: November 2022

AbstractAccording to the World Health Organization, over 300 million people worldwide are affected by major depressive disorder (MDD) [1]. Individuals battling this mental condition may exhibit symptoms including anxiety, fatigue, and self-harm, all of which severely affect well-being and quality of life. Current trends in social media and population behavior bring up an urgent need for health professionals to strengthen mental health resources, improve access and accurately diagnose depression [2]. To mitigate the disparate impact of depression on people of different social and racial groups, this study identifies factors that strongly correlate with the prevalence of depression in U.S. adults using health data from the 2019 pre-pandemic National Health Institute Survey (NHIS) [3]. In this study we trained a random forest model capable of performing a classification task on American-adults survey data with an accuracy of 98.7%. Our results conclude that age, education, income, and household demographics are the primary factors impacting mental health. Awareness of these mental health stressors may motivate medical professionals, institutions, and governments to identify more effectively the at-risk people and alleviate their potential suffering from MDD. By receiving adequate mental health services, Americans can improve their quality of life and form a more fulfilling society.
Investigation into the Phenological Patterns of Trees in Socorro Plateau, Goa
Authors: Sathya C. , Murugash M. 
Published: November 2022

AbstractPhenology is defined as the observation of biological events or life cycle phases that occur due to changes in climate and season. Primarily, phenology of all organisms is influenced by temperature fluctuations and quick climate changes which in turn regulate a variety of environmental factors. When discussing about the effects of climate change on ecosystems, phenology is especially important as many animals depend on the phenology of plants for their survival. Analysing the phenological patterns of a particular area can provide us with critical points on how ecosystems are affected by climate change. In this study, we have analysed the patterns of phenology for several trees and tried to identify any idiosyncrasies which may arise as a result of climate change and other similar factors. A total of 75 individuals belonging to 15 genera or 17 species were documented in Socorro plateau, Goa and their phenological patterns such as flowering, fruiting and leaf cover were recorded and analysed. The phenological patterns of the individual trees were compared in relation to each other such as in-between flowering and fruiting of the same species. In addition to this, the species were compared with each other in terms of their rate of flowering/fruiting to observe their inter-connected variations. Prospects for future research were identified to further promote studies in conservation biology of flora and fauna in the area and in climate change to mediate its effects.
Deep-learning based bioactive therapeutic peptides generation and screening
Authors: Zhang Haiping , Saravanan Konda Mani , Wei Yanjie , Jiao Yang , Yang Yang , Pan Yi , Wu Xuli , Zhang John Z.H. 
Published: November 2022

AbstractMany bioactive peptides demonstrated therapeutic effects over-complicated diseases, such as antiviral, antibacterial, anticancer,etc. Similar to the generatingde novochemical compounds, with the accumulated bioactive peptides as a training set, it is possible to generate abundant potential bioactive peptides with deep learning. Such techniques would be significant for drug development since peptides are much easier and cheaper to synthesize than compounds. However, there are very few deep learning-based peptide generating models. Here, we have created an LSTM model (named LSTM_Pep) to generatede novopeptides and finetune learning to generatede novopeptides with certain potential therapeutic effects. Remarkably, the Antimicrobial Peptide Database has fully utilized in this work to generate various kinds of potential activede novopeptide. We proposed a pipeline for screening those generated peptides for a given target, and use Main protease of SARS-COV-2 as concept-of-proof example. Moreover, we have developed a deep learning-based protein-peptide prediction model (named DeepPep) for fast screening the generated peptides for the given targets. Together with the generating model, we have demonstrated iteratively finetune training, generating and screening peptides for higher predicted binding affinity peptides can be achieved. Our work sheds light on to the development of deep learning-based methods and pipelines to effectively generating and getting bioactive peptides with a specific therapeutic effect, and showcases how artificial intelligence can help discoverde novobioactive peptides that can bind to a particular target.
Prescription of anti-influenza drugs in Japan, 2014-2020: a retrospective study using open data from the national claims database
Authors: Sako Akahito , Gu Yoshiaki , Masui Yoshinori , Yoshimura Kensuke , Yanai Hidekatsu , Ohmagari Norio 
Published: November 2022

ABSTRACTBackgroundBoth physicians and patients are proactive towards managing seasonal influenza in Japan and six drugs are approved. We aimed to clarify the status of anti-influenza drug use by analyzing real-world data.MethodsThis retrospective study analyzed open data from the National Database of Health Insurance Claims and Specific Health Checkups, which covers most claims data from national health insurance. We estimated the annual number of patients prescribed anti-influenza drugs, their age and sex distribution, drug costs, and regional disparities for the period 2014-2020.ResultsFor 2014-2019, an estimated 6.7-13.4 million patients per year were prescribed anti-influenza drugs, with an annual cost of 22.3-48.0 billion JPY (Japanese Yen). In addition, 21.1-32.0 million rapid antigen tests were performed at a cost of 30.1-47.1 billion JPY. In 2017, laninamivir was the most frequently prescribed anti-influenza drug (48%), followed by oseltamivir (36%), while in 2018, the newly introduced baloxavir accounted for 40.8% of prescriptions. After the emergence of COVID-19, the number of patients prescribed anti-influenza drugs in 2020 dropped to just 14,000. In 2018, 37.6% of prescriptions were for patients aged < 20 years compared with 12.2% for those aged ≥ 65 years. Prescriptions for inpatients accounted for 1.1%, and the proportion of prescriptions for inpatients increased with age. Male were more likely than female to be prescribed anti-influenza drugs for inpatient.ConclusionsBased on our clarification of how influenza is clinically managed in Japan, future work should evaluate the clinical and economic aspects of proactively prescribing anti-influenza drugs.