bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study
Authors: Mattioli Francesco , Serafini Edoardo , Lo Manto Alfredo , Mularoni Francesca , Abeshi Andi , Lionello Marco , Ferrari Marco , Paderno Alberto , Lancini Davide , Mattavelli Davide , Confuorto Gennaro , Marchi Filippo , Ioppi Alessandro , Sampieri Claudio , Mercante Giuseppe , De Virgilio Armando , Petruzzi Gerardo , Crosetti Erika , Pellini Raul , Giuseppe Spriano , Giorgio Peretti , Piazza Cesare , Molteni Gabriele , Bertolin Andy , Succo Giovanni , Nicolai Piero , Alicandri‐Ciufelli Matteo , Marchioni Daniele , Presutti Livio , Fermi Matteo 
Published: October 2022

AbstractBackgroundTo retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow‐up.MethodsIt includes patients with pT4N0 glottic SCC who underwent TL and unilateral or bilateral ND with or without PORT. Divided in two comparison groups: the first group underwent adjuvant RT (TL‐PORT); the second group referred to clinical and radiological follow‐up (TL).ResultsPORT was associated with a better OS while no differences were found in terms of DSS. A better local control is achieved when PORT is administered while no differences in terms of regional and distant control rates were found. Bilateral ND positively impacts on the regional control while the PNI negatively impact the regional control.ConclusionsA tailored PORT protocol might be considered for pT4N0 glottic SCC treated with TL and ND, both considering the ND's extent and presence of PNI.
Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy
Authors: Cao Han‐Yu , Li Ling , Xue Sheng‐Li , Dai Hai‐Ping 
Published: October 2022

AbstractEpigenetic alterations frequently participate in the onset of hematological malignancies. Histone deacetylases (HDACs) are essential for regulating gene transcription and various signaling pathways. Targeting HDACs has become a novel treatment option for hematological malignancies. Chidamide is the first oral selective HDAC inhibitor for HDAC1, HDAC2, HDAC3, and HDAC10 and was first approved for the treatment of R/R peripheral T‐cell lymphoma by the China Food and Drug Administration in 2014. Chidamide was also approved under the name Hiyasta (HBI‐8000) in Japan in 2021. In vitro studies revealed that chidamide could inhibit proliferation and induce apoptosis via cell cycle arrest and the regulation of apoptotic proteins. In clinical studies, chidamide was also efficacious in multiple myeloma, acute leukemia and myelodysplastic syndrome. This review includes reported experimental and clinical data on chidamide monotherapy or chidamide treatment in combination with chemotherapy for various hematological malignancies, offering a rationale for the renewed exploration of this drug.
Study of an unsteady fluctuative MHD flow of elasticoviscous liquid past a vertical porous plate
Authors: Muduly M. M. , Rath P. K. , Parida T. , Dash G. C. , Swain K. 
Published: October 2022

AbstractMost flows which occur in nature/practical applications are fluctuating. The fluctuating motions superimposed on the main motion are complex. Further, the unsteadiness of the flow is an added reality to applications in various fields. The free convection flow of an electrically conducting fluid past different types of vertical bodies subjected to a magnetic field is studied because of its wide range of applications in astrophysics, geophysics, aerodynamics, electromagnetic pumps, the flow of liquid metals, and so forth. In the present analysis, an attempt has been made to study the thermal radiation effect on the unsteady magnetohydrodynamic flow of an incompressible elasticoviscous liquid (Walters‐B' fluid model) along an infinite hot vertical permeable surface embedded in a porous medium with heat source and chemical reaction. The governing equations of motion, energy, and concentration are solved by an approximate analytical method, that is, the successive perturbation technique and numerical method (Runge–Kutta with shooting). The solution procedure rests upon the basic assumption that the unsteady boundary layer involves a steady basic flow superimposed on an unsteady flow. The most striking outcome is that the combined effect of oscillation outflow, the elasticity of the fluid, and thermal as well as mass buoyancy overrides the resistive electromagnetic force and suction at the plate to enhance the velocity so that high values of magnetic strength are not desired. Further, a higher value of the heat source parameter accelerates the momentum diffusion resulting in the escalation of the velocity field. Fall of concentration is relatively faster in cases of heavier species as well as destructive reactions. The heat transfer coefficient assumes positive values indicating the heat flows from the plate to the fluid (cooling of the bounding surface and heating of the fluid). These observations may have industrial (design of heat exchanges) and therapeutic bearings.
From wetlands to wetlandscapes: Remote sensing calibration of process‐based hydrological models in heterogeneous landscapes
Authors: Mullen Connor , Bertassello Leonardo E. , Rao P. Suresh C. , Müller Marc F. 
Published: October 2022

AbstractWetlands are vital components of landscapes that sustain a range of important ecosystem services. Understanding how wetland‐rich landscapes—or wetlandscapes—will evolve under a changing climate and increasing anthropogenic encroachment is urgent. Wetlandscapes are highly heterogeneous, and scaling local modelling insights from individual instrumented wetlands to characterize landscape‐scale dynamics has been a pervasive challenge. We investigate the potential to use water extent information from satellite imagery to calibrate landscape‐scale process‐based hydrological models. Applications to wetlandscapes in the Prairie Pothole Region (PPR) in North Dakota and the Texas Playa Lakes (TPL) shed light on two important trade‐offs. First, in‐situ monitoring provides accurate water extent information on an arbitrary subset of wetlands, whereas satellite imagery captures landscape‐scale hydrological dynamics but suffers persistent water‐detection challenges. Satellite imagery is a superior source of data for model calibration in sparsely monitored and spatially heterogeneous landscapes like the PPR, where the sampling uncertainty of monitored wetlands exceeds the water detection uncertainty of remote sensing. The two data sources are equivalent for more homogeneous landscapes like the TPL. The second tradeoff concerns the spatial resolution and temporal coverage of satellite imagery. In that regard, the 20 years of bi‐weekly images captured by Landsat 7 provides unprecedented insights into the dynamic nature of the ecohydrological characteristics of wetlandscapes, such as seasonal and inter‐annual changes of their metapopulation capacity. In the PPR, the amplitude of these dynamics far exceeds the bias introduced by Landsat's inability to capture ecologically important connectivity details due to its coarse spatial resolution compared to more recent imagery.
A propensity score‐matched analysis of oncological outcome after systemic therapy for stage IV colorectal cancer: Impact of synchronous ovarian metastases
Authors: van der Meer Richard , Bakkers Checca , van Erning Felice N. , Simkens Lieke H. J. , de Hingh Ignace H. J. T. , Roumen Rudi M. H. 
Published: October 2022

AbstractThe reported incidence of synchronous and metachronous ovarian metastases (OM) from colorectal cancer (CRC) is ~3.4%. OM from CRC are often considered sanctuary sites due to their lower sensitivity to systemic treatment. It has thus been hypothesized that the presence of OM decreases overall survival. Therefore, the purpose of our study was to evaluate the impact of synchronous OM on overall survival in female patients with stage IV CRC treated with systemic therapy alone with palliative intent. The present study used data from the Netherlands Cancer Registry and included female CRC patients with synchronous systemic metastases who were treated with systemic therapy between 2008 and 2018. A subsample was created using propensity score matching to create comparable groups. Propensity scores were determined using a logistic regression model in which the dependent variable was the presence of OM and the independent variables were the variables that differed significantly between both groups. Our study included 5253 patients with stage IV CRC that received systemic therapy. Among these patients, 161 (3%) had OM while 5092 (97%) had extra‐ovarian metastases only. Three‐year overall survival rates did not show a significant difference between patients with OM compared to patients without ovarian metastases. Moreover, the propensity score‐matched analysis showed that the presence of OM in patients treated with systemic therapy for stage IV CRC disease was not associated with decreased 3‐year overall survival. However, the results of the present study should be interpreted with caution, due to its observational character and used selection criteria.
Crop coefficient, reference crop evapotranspiration and water demand of dry‐season Boro rice as affected by climate variability: A case study from northeast Bangladesh
Authors: Rahman Md Abedur , Ali Mustajab , Mojid Mohammad Abdul , Anjum Naveed , Haq Md Erfanul , Kainose Ayano , Dissanayaka K. D. C. R. 
Published: October 2022

AbstractClimate variability and change significantly influence crop water demand by affecting crop coefficient (Kc), reference crop evapotranspiration (ETo, a grass reference) and potential crop evapotranspiration (ETc). The climatic effects on these hydroclimatic parameters were investigated in the past mostly for the entire crop growth period, but little or no information is available on their variation over different growth stages of the crops, specifically in Bangladesh. Therefore, this study intended to evaluate the climatic effects on these hydroclimatic parameters at the initial, development, mid‐season and late‐season growth stages of two rice varieties (Bangladesh Rice Research Institute [BRRI] dhan28 and BRRI dhan29) dominantly grown in the dry season in two northeast districts/subdistricts (Sylhet and Srimongal) as well as many other districts of Bangladesh. Kc, ET0 and ETc were analysed for the period from 1994 to 2015 using the analytical approach of the Food and Agriculture Organization (FAO) Penman–Monteith method. The results revealed that the Kc of the rice varieties increased in all growth stages over time, with the maximum Kc (1.247) in the mid‐season stage in Srimongal. ETo and ETc were found to be maximum in the mid‐season and late‐season stages, respectively. The potential crop water demand (CWRpot) greatly varied among the initial and development stages and between the two rice varieties. The initial and mid‐season growth stages of rice required more water than the other growth stages. The results on the growth stage‐wise variation of the hydroclimatic parameters pertinent to rice cultivation may greatly contribute to irrigation scheduling for dry‐season rice cultivation and planning water resources in the study region.
Label‐free detection of invasive micropapillary carcinoma of the breast using multiphoton microscopy
Authors: He Jiajia , Kang Deyong , Shen Tingfeng , Zheng Liqin , Zhan Zhenlin , Xi Gangqin , Ren Wenjiao , Chen Zhong , Qiu Lida , Xu Shuoyu , Li Lianhuang , Chen Jianxin 
Published: October 2022

AbstractInvasive micropapillary carcinoma of the breast (IMPC) is a rare form of breast cancer with unique histological features, and is associated with high axillary lymph node metastasis and poor clinical prognosis. Thus, IMPC should be diagnosed in time to improve the treatment and management of patients. In this study, multiphoton microscopy (MPM) is used to label‐free visualize the morphological features of IMPC. Our results demonstrate that MPM images are well in agreement with hematoxylin and eosin staining and epithelial membrane antigen staining, indicating MPM is comparable to traditional histological analysis in identifying the tissue structure and cell morphology. Statistical analysis shows significant differences in the circumference and area of the glandular lumen and cancer nest between the different IMPC cell clusters with complete glandular lumen morphology, and also shows difference in collagen length, width, and orientation, indicating the invasive ability of different morphologies of IMPC may be different.
Mercury and methylmercury differentially modulate hepatic cytochrome P450 1A1 and 1A2 in vivo and in vitro
Authors: Alqahtani Mohammed A. , El‐Ghiaty Mahmoud A. , El‐Kadi Ayman O. S. 
Published: October 2022

AbstractThe cytochrome P450 1 A (CYP1A) subfamily enzymes are involved in the metabolic activation of several xenobiotics to toxic metabolites and reactive intermediates, resulting ultimately in carcinogenesis. Mercury and halogenated aromatic hydrocarbons (HAHs), typified by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD), are persistent environmental pollutants involved in the modulation of aryl hydrocarbon receptor (AHR) gene battery, including cytochrome P450 (CYP) genes. We previously investigated the effect of coexposure to either inorganic or organic mercury (Hg+2 and MeHg) with TCDD on CYP1A1 in vitro. Thus, we examined the impact of coexposure to Hg+2 or MeHg and TCDD on AHR‐regulated genes (Cyp1a1/1a2) in vivo and in vitro. Therefore, male C57BL/6 mice were injected intraperitoneally with MeHg or Hg+2 (2.5 mg/kg) in the absence and presence of TCDD (15 μg/kg) for 6 or 24 h. The concentration‐dependent effect of MeHg was examined in murine hepatoma Hepa1c1c7 cells. In vivo, both MeHg and Hg2+ inhibited the TCDD‐mediated induction of Cyp1a1/1a2 mRNA levels. However, Only Hg2+ was able to inhibit the TCDD‐mediated induction at posttranscriptional levels of CYP1A1/1A2 protein and catalytic activity, suggesting differential modulation effects by Hg+2 and MeHg. In addition, the inhibitory role of HO‐1 (Heme oxygenase‐1) on CYP1A activity induced by TCDD was investigated using a HO‐1 competitive inhibitor, tin‐mesoporphyrin, that partially restored the MeHg‐mediated decrease in CYP1A1 activity. This study demonstrates that MeHg, alongside Hg2+, can differentially modulate the TCDD‐induced AHR‐regulated genes (Cyp1a1/1a2) at different expression levels in C57BL/6 mice liver and Hepa1c1c7 cells.
The importance of using routine laboratory tests in the diagnosis and prognosis of patients with coronavirus disease 2019: Shedding light on clinical laboratory data in COVID‐19
Authors: Ghaznavi‐Rad Ehsanollah , Khosravi Mahmood , Sayyadi Mohammad 
Published: October 2022

AbstractBackgroundNovel coronavirus (COVID‐19) pandemic has become a global concern and requires early detection, isolation, and treatment. Our purpose is to find some beneficial information by analyzing the COVID‐19 laboratory data to provide guidance for clinical practice.Material and MethodsIn this study, 174 patients with confirmed COVID‐19 infection were admitted. We evaluated the hematological and biochemical parameters in these patients and in 80 healthy individuals.ResultsWe found that there was significant difference between WBC, LYM, RBC, HB, and HCT parameters of patients and healthy counterparts (p < .001), though there was no remarkable change between NEU, MONO, PLT, and other characteristics of RBC values of patients and the control group (p ≥ .09). Among the evaluated biochemical parameters, the values of CK‐MB and LDH in the patient group were significantly different from the control group (p < .01), while other biochemical indicators were in the normal range.ConclusionSeveral hematological and biochemistry parameters, in particular WBC, LYM, RBC, HB, HCT, CK‐MB, and LDH, could be beneficial supplementary approach for COVID‐19 infection evaluation to confirm risk stratification and effective management.
Does atrazine induce changes in predator recognition, growth, morphology, and metamorphic traits of larval skipper frogs (Euphlyctis cyanophlyctis)?
Authors: Supekar Swapnil C. , Gramapurohit Narahari P. 
Published: October 2022

AbstractAtrazine, an info disruptor, interferes with the olfaction of aquatic organisms by impairing the chemosensory system. Consequently, it affects behavior, physiology, and growth increases mortality and infections, and suppresses the immune system of aquatic animals. In this study, we wanted to determine the sensitivity of larval Euphlyctis cyanophlyctis to different concentrations of atrazine by assessing their antipredator behavior, growth, morphology, and metamorphic traits. The results indicate that exposure to atrazine did not affect the survival of tadpoles. However, it caused retarded growth at higher concentrations. Interestingly, the antipredator behavior of tadpoles toward conspecific alarm cues decreased in a dose‐dependent manner with an increase in the concentration of atrazine. Tadpoles exposed to low concentrations of atrazine had deeper, wider bodies and tails while those exposed to higher concentrations had shallower and narrower bodies with shallower tail muscles. However, at low and moderate concentrations atrazine did not affect size at metamorphosis, it extended the larval duration at higher concentrations.
The miracle of Maglavit (1935) and the Romanian psychology of religion
Authors: Iagher Matei 
Published: October 2022

AbstractThis paper examines the debates around the “miracle of Maglavit”, a shepherd's vision of God that took place in 1935 in Romania and attracted much contemporary popular and intellectual interest. The debates drew in arguments from doctors and theologians, who discussed the psychology of divine revelation and tried to elaborate the implications that such an event could have for the life of the Romanian nation. The paper places these debates in the context of wider contemporary discussions about psychology and religion. I argue that what Maglavit shows is that, in Romania at least, public debates about visionary experience in the 1930s were not only debates about its psychology, but of a psychology thoroughly imbricated with political concerns.
Comparison of Three Ultrasmall, Superparamagnetic Iron Oxide Nanoparticles for MRI at 3.0 T
Authors: Colbert Caroline M. , Ming Zhengyang , Pogosyan Arutyun , Finn J. Paul , Nguyen Kim‐Lien 
Published: October 2022

BackgroundThe ultrasmall, superparamagnetic iron oxide (USPIO) nanoparticle ferumoxytol has unique applications in cardiac, vascular, and body magnetic resonance imaging (MRI) due to its long intravascular half‐life and suitability as a blood pool agent. However, limited availability and high cost have hindered its clinical adoption. A new ferumoxytol generic, and the emergence of MoldayION as an alternative USPIO, represent opportunities to expand the use of USPIO‐enhanced MRI techniques.PurposeTo compare in vitro and in vivo MRI relaxometry and enhancement of Feraheme, generic ferumoxytol, and MoldayION.Study TypeProspective.Animal ModelTen healthy swine and six swine with artificially induced coronary narrowing underwent cardiac MRI.Field Strength/Sequence3.0 T; T1‐weighted (4D‐MUSIC, 3D‐VIBE, 2D‐MOLLI) and T2‐weighted (2D‐HASTE) sequences pre‐ and post‐contrast.AssessmentWe compared the MRI relaxometry of Feraheme, generic ferumoxytol, and MoldayION using saline, plasma, and whole blood MRI phantoms with contrast concentrations from 0.26 mM to 2.10 mM. In‐vivo contrast effects on T1‐ and T2‐weighted sequences and fractional intravascular contrast distribution volume in myocardium, liver, and spleen were evaluated.Statistical TestsAnalysis of variance and covariance were used for group comparisons. A P value <0.05 was considered statistically significant.ResultsThe r1 relaxivities for Feraheme, generic ferumoxytol, and MoldayION in saline (22 °C) were 7.11 ± 0.13 mM−1 s−1, 8.30 ± 0.29 mM−1 s−1, 8.62 ± 0.16 mM−1 s−1, and the r2 relaxivities were 111.74 ± 3.76 mM−1 s−1, 105.07 ± 2.20 mM−1 s−1, and 109.68 ± 2.56 mM−1 s−1, respectively. The relationship between contrast concentration and longitudinal (R1) and transverse (R2) relaxation rate was highly linear in saline and plasma. The three agents produced similar in vivo contrast effects on T1 and T2 relaxation time‐weighted sequences.Data ConclusionRelative to clinically approved ferumoxytol formulations, MoldayION demonstrates minor differences in in vitro relaxometry and comparable in vivo MRI characteristics.Level of Evidence2Technical EfficacyStage 1
Banking 4.0: The era of artificial intelligence‐based fintech
Authors: Kumar Aishwarya , Srivastava Ankita , Gupta Puneet Kumar 
Published: October 2022

AbstractFinancial technology is changing the banking industry. A blend of high‐tech inventions is altering business as it reacts to unpredictability, indecisions, intricacy, and vagueness in the financial area. Banks are embracing this change and adapting financial technology in their banking products and services in customer advisory, artificial intelligence models, blockchain security, and many more. Given the dearth of literature on the arising subject of Fintech banking this paper provides a status quo and the trend of Fintech banking. A review is done of 3268 documents from the data extracted from Google Scholar for the year 1966–2021. Qualitative analysis including co‐occurrence analysis and the trend analysis was applied with the help of documents analysis, citation analysis, influential journals and authors, and leading countries in the research space. The results were achieved using the NVivo and Vosviewer software. The results identified significant topics trending in this space which include credit risk, artificial intelligence models, robot‐advisory, and decentralized blockchain usage in banking management.
Eosinophilic dermatosis of haematological malignancy (EDHM): A series of nine cases
Authors: Bakr Farrah , Costa Joaninha , Cabecadas Jose , Cabrera Rafael , Cravo Mariana , Rafael Margarida , Bakshi Arti , Robson Alistair 
Published: October 2022

AbstractBackgroundNonspecific cutaneous eruptions in patients with haematological malignancies are not uncommon. Eosinophilic dermatosis of haematological malignancy (EDHM), previously known as an ‘insect bite‐like’ reaction, has been reported in a wide range of haematological malignancies, most commonly chronic lymphocytic leukaemia. Its exact pathogenetic mechanism is unclear.ObjectivesTo further characterise this eruption, review the literature of this rare condition and discuss its nosological status with respect to several differential diagnoses.MethodsNine patients with a diagnosis of EDHM were identified retrospectively and the clinical and histological features were reviewed.ResultsThe morphology of the cutaneous eruptions varied between patients with macules, papules, nodules, vesicles or bullae all reported. Eight out of the nine cases had a known underlying malignancy. The cutaneous eruption preceded and led to the diagnosis of a splenic marginal zone lymphoma in one patient. Eosinophils were identified in all histological specimens. Other common features included bullae, lymphocytic infiltrates and apoptotic keratinocytes. CD20(+) B‐cells were only observed in one case.ConclusionsWe present a series of nine patients with EDHM associated with a range of haematological malignancies and with varied clinical presentations. The histological features however were consistent. We postulate potential mechanisms underlying the pathogenesis of this uncommon condition, which is most likely due to a dysregulated immune system driving a T‐cell and eosinophil‐mediated hypersensitivity reaction.