bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactive Effect of Retrogradation and Addition of Pulses, Cooking Oil on Predicted Glycemic Index and Resistant Starch of Potato
Authors: Lal Milan Kumar , Singh Brajesh , Tiwari Rahul Kumar , Kumar Sudhir , Gopalakrishnan S. , Gaikwad Kishor , Kumar Awadhesh , Paul Vijay , Singh Madan Pal 
Published: January 2022

AbstractPotato is consumed as boiled, microwaved, baked, or fried and in combination with pulses and/or oils which might affect the postprandial blood glucose response. The effect of the combination of potato with pulses/oils followed by retrogradation is investigated on the predicted glycemic index (GI), resistant starch (RS), and related parameters. The addition of pulses to potato results in lowering of GI and enhancement of RS. Moreover, retrogradation (4°C for 48 h) of potato‐pulse combination shows a GI lowering effect compared to control. Out of eight pulses, pigeon pea and kidney beans are more effective in lowering GI and increasing RS. The addition of oils to potato during cooking results in the reduction of GI and glycemic load (GL), with an increase in RS. Further, storage of cooked potato‐oil combination at 4°C for 48 h results in the reduction of GI and increase in RS. Out of seven cooking oils, olive oil and ghee (clarified butter) bring about an effective lowering of GI and GL. The results suggest that the addition of pulses and cooking oil to potato, followed by cooling might be an effective approach in managing the postprandial rise in the levels of blood glucose.
Licochalcone E inhibits trxR1 expression, alters Nrf2/STAT6 signal, and induces antitumor effects in vitro against human SH‐SY5Y and SK‐N‐BE(2) neuroblastoma cells
Authors: Zhang Qian , Zhang Jingjing , Liu Bailing , Wei Jingli 
Published: January 2022

AbstractNeuroblastoma (NB) is the most common solid tumor of the sympathetic nervous system (SNS) arising in childhood less than 15 years age. Licochalcone (Lic) is known to show inhibitory effects in cancer growth, and there has evidence suggested that Lic A inhibits hypoxic induced NB SK‐N‐SH cell proliferation. However, it is unclear whether LicE exerts similar effects in NB and the associated molecular mechanism of Lic in neuroblastoma is still unclear. In the current study, we found that LicE at the concentration 2, 4 and 6 μM all induced a profound reduction in cell viability, colony formation and cell proliferation. Next, LicE treatment effectively promoted cell apoptosis, inhibited cell migration and invasion. LicE significantly suppressed trxR1 expression, activated Nrf2 expression and inhibited STAT6 expression in SH‐SY5Y and SK‐N‐BE(2) NB cells. We further identified that trxR1, STAT6 overexpression or Nrf2 silence reversed the antitumor effects of LicE in human SH‐SY5Y and SK‐N‐BE(2) NB cells. Finally, LicE treatment significantly inhibited tumor growth in nude mice carrying a SK‐N‐SH cell xenograft. These results provide new insights into the effects and highlighting a novel mechanism of LicE through regulating trxR1/Nrf2/STAT6 signal pathway in NB.
Outbreak of acute highly lethal phlegmon in the pharynx, associated with a new Pasteurella multocida MLST type ST63, in a limousine herd
Authors: González‐Martín Juan V. , Pérez‐Villalobos Natividad , Patrón‐Collantes Raquel , González Fernández Jorge , Vela Ana Isabel 
Published: January 2022

AbstractWe report an outbreak of pharyngeal inflammation in an extensive limousine herd, in central Spain, associated with a novel genotype (ST63) of Pasteurella multocida capsular serogroup B (capB). The outbreak affected cattle of all ages, reaching a herd‐level death rate of 17.6% and case fatality rate of 93.3%. Affected animals showed throat inflammation, respiratory distress and finally death, without characteristics of depression or haemorrhagic septicaemia in an acute course. Postmortem examination only revealed inflammation, including oedema in the pharynx and surrounding tissues. None of the necropsied animals was septicaemic and none showed multisystem petechial haemorrhages, pneumonia or enteritis characteristics of haemorrhagic septicaemia. P. multocida was isolated, serotyped and characterised as capB and, with the multihost P. multocida multilocus sequence typing database, isolates were assigned to the new sequence type ST63. Results of this study suggest that capB P. multocida type ST63 should be considered in the differential diagnoses of acute throat inflammation in cattle.
Race, Animal Bodies and Religion: Sacrifice, Sensory Politics and Public Space in South Africa
Authors: Tayob Shaheed 
Published: January 2022

AbstractIn South Africa, previous analyses of religious nationalism turn on the apartheid regime and its close ties to the Dutch Reformed Church. Since the fall of apartheid, democracy and pluralism have been emphasized as the discourse of the new South Africa, which aims to accommodate all of South Africa’s many religious traditions. Together with decades of neoliberal economic policy, the outcome is that in South Africa private individuals and organizations make claims on public spaces as rate-payers and property-owners, in the process revealing normative assumptions about proper and improper religions. Drawing attention to two instances of the manipulation of animal bodies in public spaces, the chapter reveals the close connections between religion, animal sacrifice, racial hierarchy and conflicts over the use of and access to public spaces. The public practice of animal sacrifice reveals the existence of a sensory politics enacted by marginalized groups through which entrenched normativities about proper and improper bodies, substances and religions are contested in the name of a future nation to come.
On the ‘Impossibility’ of Atheism in Secular India
Authors: Binder Stefan 
Published: January 2022

AbstractThis chapter examines two cinematic representations of atheism in Bollywood cinema and probes the precarious location of atheism as an ‘impossibility’ within the framework of religious nationalism and state secularism as two interrelated aspects of Indian nationalism. The historical genesis of secularism as a political principle in India is conceptually closely entwined with religious nationalism in so far as it tends to take the religious or spiritual nature of the Indian nation for granted. While public and academic debates tend to focus on the relationship between majoritarian Hindu nationalism and various religious minorities, atheists and those who are explicitly irreligious are often ignored or considered to be too few to deserve closer attention. On the basis of popular cinematic representations of atheism and ethnographic observations among atheists in South India, this chapter argues that atheism is not ejected from the imagined community of the Indian nation but marginalized as a discursive position that may be acceptable or even desirable within limits, but ultimately impossible as a viable practical project and social identity.
Rising, Becoming, Overcoding: On Chinese Nationalism in The Wandering Earth
Authors: de Kloet Jeroen 
Published: January 2022

AbstractIn the 2019 Chinese sci-fi blockbusterThe Wandering Earthby Frant Guo, audiences are catapulted into a dystopian 2061. The movie brings to mind a strong Hollywood genre style and history. This comparative logic runs the danger of accusing China of making a belated copy feeding into a desire to assert its Chineseness. Peter van der Veer has shown how pivotal comparative analyses are to understanding complexity and resisting generalizations. Anthropology is well equipped for this task, but as I argue in this chapter, so are cultural studies and cultural analysis. Drawing on Peter van der Veer’s work in tandem with Rey Chow, this chapter reads the movie as a translation of the sci-fi genre that betrays both its assumed origin and the copy.
Smooth interpolation between thermal Born and LPM rates
Authors: Ghiglieri J. , Laine M. 
Published: January 2022

Abstract
In a weakly coupled ultrarelativistic plasma, 1 + n ↔ 2 + n scatterings, with n ≥ 0, need sometimes to be summed to all orders, in order to determine a leading-order interaction rate. To implement this “LPM resummation”, kinematic approximations are invoked. However, in cosmological settings, where the temperature changes by many orders of magnitude and both small and large momenta may play a role, such approximations are not always justified. We suggest a procedure to smoothly interpolate between LPM-resummed 1 + n ↔ 2 + n and Born-level 1 ↔ 2 results, rendering the outcome applicable to a broader range of masses and momenta. The procedure is illustrated for right-handed neutrino production from a Standard Model plasma, and dilepton production from a QCD plasma.
Graviton corrections to the Newtonian potential using invariant observables
Authors: Fröb M. B. , Rein C. , Verch R. 
Published: January 2022

Abstract
We consider the effective theory of perturbative quantum gravity coupled to a point particle, quantizing fluctuations of both the gravitational field and the particle’s position around flat space. Using a recent relational approach to construct gauge-invariant observables, we compute one-loop graviton corrections to the invariant metric perturbation, whose time-time component gives the Newtonian gravitational potential. The resulting quantum correction consists of two parts: the first stems from graviton loops and agrees with the correction derived by other methods, while the second one is sourced by the quantum fluctuations of the particle’s position and energy-momentum, and may be viewed as an analog of a “Zitterbewegung”. As a check on the computation, we also recover classical corrections which agree with the perturbative expansion of the Schwarzschild metric.
On the Bingham Flow in a Thin Y-Like Shaped Structure
Authors: Bunoiu Renata , Gaudiello Antonio 
Published: January 2022

AbstractWe consider the steady Bingham flow in a two-dimensional thin Y-like shaped structure, with no-slip boundary conditions and under the action of given external forces. After passage to the limit with respect to a small parameter related to the thickness of the domain, we obtain three uncoupled problems. Each of these problems describes an anisotropic flow, corresponding to a lower-dimensional “Bingham-like” constitutive law. These results are in accordance with the engineering models.
From Short-Range to Contact Interactions in Two-dimensional Many-Body Quantum Systems
Authors: Griesemer Marcel , Hofacker Michael 
Published: January 2022

AbstractQuantum systems composed of N distinct particles in $$\mathbb {R}^2$$

R

2

with two-body contact interactions of TMS type are shown to arise as limits—in the norm resolvent sense—of Schrödinger operators with suitably rescaled pair potentials.
Identification of bisphenols and derivatives in greenhouse dust as a potential source for human occupational exposure
Authors: Caballero-Casero Noelia , Rubio Soledad 
Published: January 2022

AbstractBisphenol A (BPA) and alternative bisphenols are widely used in the industrial production of polycarbonates and resin polymers. Adverse effects on human health have been described for BPA and owing to the structural similarity of alternative bisphenols and derivatives, a similar toxicity profile is expectable. Dust can act as a sink for bisphenols owing to the large surface area to mass ratio. Human risk exposure to bisphenols via indoor dust has been widely assessed in the last decade. The environmental conditions inside greenhouses, among other factors, facilitate that chemicals are released from greenhouse building materials to dust. This study aims to explore for the first time the potential of greenhouse dust as a new source of bisphenols for human exposure. For this purpose, a supramolecular solvent-based method was applied to the extraction of twenty-one bisphenols from greenhouse dust, prior to their determination by liquid chromatography–tandem mass spectrometry. Nineteen bisphenols were found in the five greenhouse dust samples analysed, with concentrations ranging from 5275 ng g−1 (BPA) to 0.25 ng g−1 (trichlorobisphenol A). The average daily dose (ADD) via dust ingestion for bisphenol compounds was calculated, in order to estimate the occupational exposure for inadvertent dust ingestion. Despite the calculated ADD value for BPA (47.81 ng kg−1 day−1) being below the tolerable daily intake proposed by EFSA (4·103 ng kg−1 day−1), this value was considerably higher than those previously reported for indoor dust, which brings to light the importance of considering greenhouse dust as bisphenols source of exposure for greenhouse workers.
Graphical abstract
Automated liquid handling robot for rapid lateral flow assay development
Authors: Anderson Caitlin E. , Huynh Toan , Gasperino David J. , Alonzo Luis F. , Cantera Jason L. , Harston Stephen P. , Hsieh Helen V. , Marzan Rosemichelle , McGuire Shawn K. , Williford John R. , Oncina Ciela I. , Glukhova Veronika A. , Bishop Joshua D. , Cate David M. , Grant Benjamin D. , Nichols Kevin P. , Weigl Bernhard H. 
Published: January 2022

AbstractThe lateral flow assay (LFA) is one of the most popular technologies on the point-of-care diagnostics market due to its low cost and ease of use, with applications ranging from pregnancy to environmental toxins to infectious disease. While the use of these tests is relatively straightforward, significant development time and effort are required to create tests that are both sensitive and specific. Workflows to guide the LFA development process exist but moving from target selection to an LFA that is ready for field testing can be labor intensive, resource heavy, and time consuming. To reduce the cost and the duration of the LFA development process, we introduce a novel development platform centered on the flexibility, speed, and throughput of an automated robotic liquid handling system. The system comprises LFA-specific hardware and software that enable large optimization experiments with discrete and continuous variables such as antibody pair selection or reagent concentration. Initial validation of the platform was demonstrated during development of a malaria LFA but was readily expanded to encompass development of SARS-CoV-2 and Mycobacterium tuberculosis LFAs. The validity of the platform, where optimization experiments are run directly on LFAs rather than in solution, was based on a direct comparison between the robotic system and a more traditional ELISA-like method. By minimizing hands-on time, maximizing experiment size, and enabling improved reproducibility, the robotic system improved the quality and quantity of LFA assay development efforts.
Graphical abstract
Graded matrix factorizations of size two and reduction
Authors: Ebeling Wolfgang , Takahashi Atsushi 
Published: January 2022

AbstractWe associate a complete intersection singularity to a graded matrix factorization of size two of a polynomial in three variables. We show that we get an inverse to the reduction of singularities considered by C. T. C. Wall. We study this for the full strongly exceptional collections in the triangulated category of graded matrix factorizations constructed by H. Kajiura, K. Saito, and the second author.
PD1/PD-L1 immune checkpoint as a potential target for preventing brain tumor progression
Authors: Filippone A. , Lanza M. , Mannino D. , Raciti G. , Colarossi C. , Sciacca D. , Cuzzocrea S. , Paterniti I. 
Published: January 2022

AbstractProgrammed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell collapse. The binding of PD-1 to its ligand programmed death-ligand 1 (PD-L1) activates downstream signaling pathways and inhibits T cell activation in the perspective of immune system mechanism and regulation in tumor progression. It is well reported that tumors adopt certain immune-checkpoint pathways as a mechanism of resistance against immune cells such as T cells that are specific for tumor antigens. Indeed, the PD-1/PD-L1 pathway controls the induction and maintenance of immune tolerance within the tumor microenvironment. Thus, the PD-1/PD-L1 checkpoint regulation appears to be of extreme importance as well as the immunotherapy targeting that via and the using of PD-1/PD-L1 inhibitors that have changed the scenario of brain cancer treatment and survival. Here, we review the mechanism of action of PD-1 and PD-L1, the PD/PDL-1 signaling pathway involved in the progression of brain tumors, and its application as cancer immunotherapy counteracting tumor escape in central nervous system.
Still room for improvement in traditional 3D interaction: selecting the fixed axis in the virtual trackball
Authors: Gonzalez-Toledo Daniel , Cuevas-Rodriguez Maria , Molina-Tanco Luis , Reyes-Lecuona Arcadio 
Published: January 2022

AbstractVirtual trackball techniques are widely used when 3D interaction is performed through interfaces with a reduced number of degrees of freedom such as mice and touchscreens. For decades, most implementations fix a vertical axis of rotation, which is a suitable choice when the vertical axis should indeed be fixed, according to some mental model of the user. We conducted an experiment involving the use of a mouse and a touch device to study usability in terms of performance, perceived usability and mental workload when selecting different fixed axes in accordance with the user’s mental model. The results we obtained indicate that the consistency between the axis fixed by the technique and the object’s intrinsic axis has a positive effect on usability. We believe that implementations that allow to select different fixed axis for each specific object should be considered when designing future reduced-DoF interaction interfaces.
Screening for anti-adipogenic, pro-lipolytic and thermogenic plant extracts by models associating intestinal epithelial cells with human adipose cells
Authors: Guillemet Damien , Belles Chloé , Gomes Aurélie , Azalbert Vincent , André Mathilde , Faresse Nourdine , Burcelin Rémy , Lagarde Jean-Michel , Lacasa Danièle , Kéophiphath Mayoura 
Published: January 2022

Abstract
Purpose
Excessive fat mass accumulation in obesity leads to diverse metabolic disorders, increased risks of cardiovascular diseases and in some cases, mortality. The aim of this study was to screen the actions of botanical extracts intended for oral use on human adipose tissue, using an in vitro screening model combining human intestinal cells with human adipose cells. This was to find the most effective extracts on lipid accumulation, UCP1 expression and ATP production in pre-adipocytes and on adipocyte lipolysis.

Methods
In this study, 25 individual plant extracts were screened for their effects on human adipose cells. Consequently, an original in vitro model was set up using the Caco-2 cell line, to mimic the intestinal passage of the extracts and then exposing human adipose cells to them. The biological actions of extracts were thus characterized, and compared with a coffee extract standard. The most effective extracts, and their combinations, were retained for their actions on lipid accumulation, the expression of the thermogenic effector UCP1 and ATP production in pre-adipocytes as well as on lipolysis activity of mature adipocytes.

Results
The biphasic culture system combining human Caco-2 cells with human adipose cells was verified as functional using the green coffee extract standard. Out of the 25 plant extracts studied, only 7 and their combinations were retained due to their potent effects on adipose cells biology. The data showed that compared to the coffee extract standard, Immortelle, Catechu, Carrot and Rose hip extracts were the most effective in reducing lipid accumulation and increased UCP1 expression in human pre-adipocytes.

Conclusion
This study reveals the potential inhibitory effects on lipid accumulation and thermogenic activity of Immortelle, Catechu, Carrot and Rose hip extracts, and for the first time synergies in their combinations, using an in vitro model mimicking as closely as possible, human intestinal passage linked to adipose cells. These findings need to be confirmed by in vivo trials.
Influence of sportive activity on functional and radiographic outcomes following reverse total shoulder arthroplasty: a comparative study
Authors: Geyer Stephanie , Siebler Jakob , Eggers Felipe , Münch Lukas N. , Berthold Daniel P. , Imhoff Andreas B. , Siebenlist Sebastian , Scheiderer Bastian 
Published: January 2022

Abstract
Background
The purpose of the present study was to compare the functional and radiographic outcomes following reverse total shoulder arthroplasty (RTSA) in a senior athletic and non-athletic population.

Material and methods
In this retrospective cohort study, patients who underwent RTSA between 06/2013 and 04/2018 at a single institution were included. Minimum follow-up was 2 years. A standardized questionnaire was utilized for assessment of patients’ pre- and postoperative physical fitness and sportive activity. Patients who resumed at least one sport were assigned to the athletic group, while patients who ceased participating in sports were assigned to the non-athletic group. Postoperative clinical outcome measures included the Constant score (CS), American Shoulder and Elbow Surgeons (ASES) score, Simple Shoulder Test (SST), and visual analog scale (VAS) for pain. Active shoulder range of motion (ROM) and abduction strength were assessed. Radiographic evaluation was based on a standardized core set of parameters for radiographic monitoring of patients following shoulder arthroplasty.

Results
Sixty-one of 71 patients (85.9%; mean age: 72.1 ± 6.6 years) were available for clinical and radiographic follow-up at a mean of 47.1 ± 18.1 months. Thirty-four patients (55.7%) were assigned to the athletic group and 27 patients (44.3%) to the non-athletic group. The athletic group demonstrated significantly better results for CS (P = 0.002), ASES score (P = 0.001), SST (P = 0.001), VAS (P = 0.022), active external rotation (P = 0.045) and abduction strength (P = 0.016) compared to the non-athletic group. The overall rate of return to sport was 78.0% at an average of 5.3 ± 3.6 months postoperatively. Incomplete radiolucent lines (RLL) around the humeral component were found significantly more frequently in the athletic group compared to the non-athletic group (P = 0.019), whereas the occurrence of complete RLLs around the implant components was similar (P = 0.382). Scapular notching was observed in 18 patients (52.9%) of the athletic group and 12 patients (44.9%) of the non-athletic group (P = 0.51). The overall rate for revision surgery was 8.2%, while postoperative complications were encountered in 3.3% of cases.

Conclusion
At mid-term follow-up, the athletic population demonstrated significantly better clinical results following RTSA without a higher rate of implant loosening and scapular notching when compared to non-athletic patients. However, incomplete radiolucency around the humeral component was observed significantly more often in the athletic group.

Level of evidence
III.