bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of technological factors on milk quality indicators
Authors: Sokoliuk V. M. , Dukhnytsky V. B. , Krupelnytsky T. V. , Ligomina I. P. , Revunets A. S. , Prus V. M. 
Published: May 2022

The article presents a study of the organization of milk production technology on the farm with tethered and tethered-boxing of cows. It has been established that one of the departments uses Dairy Plan C21 herd management software. This makes it possible to obtain comprehensive data on milk productivity, health, and behavior of each cow, group of animals, and the herd. Pre- and post-milking treatment of cows' teats with means based on a probiotic culture of Bacillus subtilis, Forticept® Udder Wash, and Zooprotect. According to the research results, data on production and sales were obtained, and indicators of quality and safety of whole raw milk from two departments were analyzed. Gross milk production for the year at section 1 with free-range boxing of cows was 1875.4 tons, the average annual yield per cow – 7381 kg, milk marketability – 96.3 %. The production figures for section № 2 with tethered animals were – 1324.2 tons, 7333 kg, and 96.5 %, respectively. The study found that the average annual amount of MAFANM in milk from cows at tethered housing was 37 ± 3.6 × 104 thousand CFU/cm3; loose-box – 35 ± 4.1 × 104 thousand CFU/m3; the number of somatic cells is 327.8 ± 28.73 and 332.1 ± 29.91 thousand cm3, respectively. In the milk of cows from section № 2 the protein content was 3.19 ± 0.067 %, fat – 3.78 ± 0.106 %, fat/protein ratio – 1.18 : 1. Slightly higher values were obtained when studying cows' milk from the sections № 1 – 3.22 ± 0.033; 3.88 ± 0.093 %, and 1.21 : 1, respectively. According to normative indicators, the fat/protein ratio is 1.2–1.4 : 1. It should be noted that deviations from these indicators indicate a violation of metabolic processes in cows. Indicators of acidity and density in cow's milk were within the normative values. According to research, no heavy metals, pesticides, radionuclides, or inhibitors have been detected in whole raw milk. Therefore, analyzing the data obtained, it should be noted that the milk produced on the farm and sold to processing enterprises meets the requirements for quality milk. According to the national standard, it is suitable for producing quality and safe products.
Método líquen pode promover o cálculo mental
Authors: Zancan Sabrina , Andreas Sauerwein Ricardo 
Published: May 2022

O Método Líquen foi desenvolvido com o objetivo de auxiliar professores e alunos na construção dos conhecimentos necessários às estratégias de cálculo mental. Neste artigo, investigamos se a utilização do Método Líquen promoveu o desenvolvimento de estratégias de cálculo mental. Para isso, investigamos as estratégias de cálculo de 95 alunos, de quatro turmas, que utilizaram o método por dois ou três anos consecutivos. Destes, identificamos 56 alunos utilizando ou com indícios da utilização de cálculo mental, o que representa 58,9% do total de alunos investigados. Concluímos, assim, que a implementação do Método Líquen nas escolas traz bons resultados para a aprendizagem dos alunos, a longo prazo, promovendo a uniformidade da turma e o desenvolvimento do cálculo mental.
ANALISIS KUALITATIF PENGENDALIAN COVID-19 BERDASARKAN KEKUATAN PENTAHELIX DI WILAYAH PARIWISATA KABUPATEN PANGANDARAN
Authors: Astuti Endang Puji 
Published: May 2022

Kasus COVID-19 tidak hanya tanggung jawab bidang kesehatan saja, dalam penanganannya perlu kerjasama berbagai lintas sektor. Kabupaten Pangandaran sebagai lokasi wisata dan Kabupaten baru di Jawa Barat membutuhkan optimalisasi peran pentahelix dalam upaya pengendalian COVID-19. Tujuan dari penelitian yaitu mengidentifikasi peran pentahelix dalam implementasi penanganan COVID-19 di Kabupaten Pangandaran. Penelitian ini merupakan penelitian kualitatif dengan teknik wawancara mendalam (indepth interview). Informan kunci dalam penelitian ini terdiri dari 50 informan yang berasal dari leading sektor (Dinas Kesehatan, Labkesda, Rumah Sakit dan Puskesmas), lintas sektor (Kecamatan, Desa), dan Satuan Tugas (Satgas) COVID-19. Hasil menunjukkan, implementasi kebijakan merujuk pada kebijakan pusat, dengan menerbitkan Keputusan Bupati Kabupaten Pangandaran Nomor 443/Kpts.92-Huk/2020 tentang Gugus Tugas (Satgas) Percepatan Penanggulangan COVID-19. Peran dan kerjasama telah berjalan dengan baik dengan memanfaatkan wadah Satgas COVID-19 dengan semua pihak mengambil peran masing-masing dalam mendukung upaya tersebut. Faktor pendukung meliputi penerbitan Keputusan Bupati, pemberian insentif dan pemahaman masyarakat yang bagus. Sedangkan faktor penghambat berupa kekurangan SDM, sarana dan prasarana serta stigma negatif yang diterima oleh tenaga medis dan pasien COVID-19 khususnya pada awal-awal pandemi. Kegiatan pemberdayaan masyarakat telah dilakukan dengan melibatkan tim Satgas tingkat kecamatan dan desa melalui kegiatan Musyawarah Masyarakat Desa. Peran pentahelix dalam implementasi penanganan COVID-19 di Kabupaten Pangandaran secara umum telah berjalan dengan baik terlihat dengan penerbitan Keputusan Bupati yang menjadi kekuatan hukum pelaksanaan kerjasama dan kolaborasi pentahelix dalam pelaksanaan pengendalian COVID-19 di Kabupaten Pangandaran. Semua pihak mengambil peran masing-masing dalam mendukung upaya tersebut. Faktor hambatan berupa kekurangan SDM, sarana dan prasarana serta stigma negatif pada awal pandemi telah berkurang meskipun tetap ada beberapa yang masih menjadi penghambat. Kegiatan pemberdayaan melalui Musyawarah Masyarakat Desa belum mengerucut pada rencana kegiatan yang menjadi inisiatif desa sehingga perlu upaya dalam menggerakan masyarakat untuk bersinergi dalam peningkatan peran serta dan menginisiasi proses tahapan pemberdayaan masyarakat.
Kata kunci: pentahelix, penanganan, COVID-19, Pangandaran
Knowledge Domain and Hotspots Predict Concerning Electroactive Biomaterials Applied in Tissue Engineering: A Bibliometric and Visualized Analysis From 2011 to 2021
Authors: Xiong Wentao , Wang Sheng , Wei Ziheng , Cai Yibo , Li Bo , Lin Feng , Xia Demeng 
Published: May 2022

Objective: Electroactive biomaterials used in tissue engineering have been extensively studied. Electroactive biomaterials have unique potential advantages in cell culture and tissue regeneration, which have attracted the attention of medical researchers worldwide. Therefore, it is important to understand the global scientific output regarding this topic. An analysis of publications on electroactive biomaterials used in tissue engineering over the past decade was performed, and the results were summarised to track the current hotspots and highlight future directions.Methods: Globally relevant publications on electroactive biomaterials used in tissue engineering between 2011 and 2021 were extracted from the Web of Science database. The VOSviewer software and CiteSpace were employed to visualise and predict trends in research on the topic.Results: A total of 3,374 publications were screened. China contributed the largest number of publications (995) and citations (1581.95, actual value ×0.05). The United States achieved the highest H-index (440 actual values ×0.05). The journal Materials Science &amp; Engineering C-materials for Biological Applications (IF = 7.328) published the most studies on this topic (150). The Chinese Academy of Science had the largest number of publications (107) among all institutions. The publication titled Nanotechnological strategies for engineering complex tissues by Dir, T of the United States had the highest citation frequency (985 times). Regarding the function of electroactive materials, the keyword “sensors” emerged in recent years. Regarding the characterisation of electroactive materials, the keyword “water contact angle” appeared lately. Regarding electroactive materials in nerve and cardiac tissue engineering, the keywords “silk fibroin and conductive hydrogel” appeared recently. Regarding the application of electroactive materials in bone tissue engineering, the keyword “angiogenesis” emerged in recent years. The current research trend indicates that although new functional materials are constantly being developed, attention should also be paid to their application and transformation in tissue engineering.Conclusion: The number of publications on electroactive biomaterials used in tissue engineering is expected to increase in the future. Topics like sensors, water contact angle, angiogenesis, silk fibroin, and conductive hydrogels are expected to be the focuses of research in the future; attention should also be paid to the application and transformation of electroactive materials, particularly bone tissue engineering. Moreover, further development of the field requires joint efforts from all disciplines.
Cytotoxicity and Bonding Property of Bioinspired Nacre-like Ceramic-Polymer Composites
Authors: Sun Hui , Gao Kefeng , Yi Zhe , Han Chengwei , Liu Zengqian , Wang Qiang , Zhou Qing , Zhang Zhefeng 
Published: May 2022

For clinical applications, non-cytotoxicity and good bonding property of dental restorative materials are the most essential and important. The aim of this study was to evaluate the potential for clinical applications of two novel bioinspired nacre-like ceramic (yttria-stabilized zirconia)-polymer (polymethyl methacrylate) composites in terms of the cytotoxicity and bonding property. The relative growth rates (24 h) of the Lamellar and Brick-and-mortar composites measured by CCK8 were 102.93%±0.04 and 98.91%±0.03, respectively. According to the results of cytotoxicity and proliferation experiments, the two composites were not cytotoxic to human periodontal ligament fibroblasts (HPDLFs) in vitro. Both composites exhibited improved bonding strength as compared to the Control group (Vita In-Ceram YZ). As the polymer content in the composite material increases, its bonding strength also increases, which enhances the application potential of the material in the field of dental restoration. Meanwhile, by controlling the direction of loading force in the shear test, the effect of microstructure on the bonding strength of anisotropic composites was studied. After sandblasted, the bonding strengths of the Lamellar group in the longitudinal and transverse shear directions were 17.56±1.56 MPa and 18.67±1.92 MPa, respectively, while of the Brick-and-mortar group were 16.36±1.30 MPa and 16.99±1.67 MPa, respectively. The results showed that the loading direction had no significant effect on the bonding strength of the composites.
Traditional Structures in Turkey and Greece in 30 October 2020 Aegean Sea Earthquake: Field Observations and Empirical Fragility Assessment
Authors: Aktas Yasemin D , Ioannou Ioanna , Malcioglu Fatma Sevil , Vatteri Ahsana Parammal , Kontoe Maria , Donmez Kokcan , Black Jacob , Kazantzidou-Firtinidou Danai , Dermanis Panagiotis , Diri‐Akyildiz Filiz 
Published: May 2022

On 30th October 2020, an earthquake of magnitude 6.9 hit the Aegean coasts of Turkey and Greece. The epicentre was some 14 km northeast of Avlakia settlement on Samos Island, and 25 km southwest of Turkish town Seferihisar, Izmir. The destruction the earthquake caused concentrated mainly on the mid-rise RC buildings in certain districts of Izmir city. Among the diverse building typologies affected by the event are the traditional/vernacular hybrid timber-masonry and masonry buildings that are common to Turkey and Greece. This paper summarises and discusses the damage levels and mechanisms observed in these types of buildings, based on an extensive field and remote reconnaissance survey in the affected areas in both countries conducted by the Earthquake Engineering Field Investigation Team (EEFIT) of the United Kingdom Institute of Structural Engineers (IStructE). The observed damage is then discussed in light of the level of maintenance and occupancy status. The collected data are also used to empirically construct fragility curves, to assess whether a small sample can be used to describe the overall performance of the buildings in the area and how these compare to the outcomes of previous studies on comparable building stocks.
Tp-Te Interval and Tp-Te/QT Ratio Are Valuable Tools in Predicting Poor Outcome in Sepsis Patients
Authors: Li Duo , Weng Yibing , Zhen Genshen , Jiang Li 
Published: May 2022

ObjectiveAbout 50% of patients with sepsis have different degrees of myocardial inhibition, known as sepsis-induced myocardial dysfunction (SMD), which increases the mortality rate of sepsis. Tp-Te interval and Tp-Te/QT ratio reflect ventricular transmural dispersion repolarization (TDR), and have good predictive value for death in patients with heart disease. This study aimed to investigate the prognostic value of Tp-Te and Tp-Te/QT in patients with sepsis.MethodsThe current study included a total of 625 participants: 201 patients with sepsis, 213 patients with heart failure, and 211 healthy participants. According to the severity and outcome, the patients with sepsis were divided into the sepsis group and the septic shock group, and the death group and the survival group to explore the differences of indicators among subgroups of sepsis. The ROC curve was used to analyze the predictive value of the indicators for deaths of patients with sepsis and calculate the cutoff point. Then, we investigated the incidence of arrhythmia in patients with sepsis with different TDR. The correlation between Tp-Te/QT and the commonly used predictive indicators in ICU was also discussed.Results(1) Tp-Te and Tp-Te/QT in patients with sepsis and heart failure (HF) were significantly higher than the control group (p &lt; 0.01). (2) Compared with patients with sepsis, the increase of Tp-Te and Tp-Te/QT is more prominent in patients with HF. Especially, the increase of the Tp-Te/QT was statistically significant (p &lt; 0.001). (3) compared with patients with sepsis (no shock), the Tp-Te, Tp-Te/QT, and SOFA were increased in patients with septic shock (p &lt; 0.05). (4) In the death group, Tp-Te /QT, SOFA, and Apache-II were higher; LVEF was lower than the survival group (p &lt; 0.05). (5) ROC curves showed that Tp-Te/QT, SOFA, and LVEF have predictive values for death (p &lt; 0.05; AUC = 0.808, 0.716, 0.412). The cutoff point of Tp-Te/QT was 0.32. (6) The incidence of arrhythmia is different in patients with sepsis with different TDR. (7) There is a significant correlation between Tp-Te/QT and SOFA (p &lt; 0.001, r = 0.79).ConclusionTDR in patients with sepsis is significantly increased, which was between healthy population and patients with HF. Tp-Te and Tp-Te/QT are effective indicators to reflect the severity and poor outcome of patients with sepsis.
Echocardiography-Guided Percutaneous Patent Ductus Arteriosus Closure: 1-Year Single Center Experience in Indonesia
Authors: Siagian Sisca Natalia , Prakoso Radityo , Putra Bayushi Eka , Kurniawati Yovi , Lelya Olfi , Sembiring Aditya Agita , Atmosudigdo Indriwanto Sakidjan , Roebiono Poppy Surwianti , Rahajoe Anna Ulfah , Harimurti Ganesja Moelia , Mendel Brian , Christianto Christianto , Setiawan Moira , Lilyasari Oktavia 
Published: May 2022

IntroductionSince the first successful percutaneous closure under transesophageal echocardiographic (TEE) guidance, many centers explored transcatheter procedures without fluoroscopy. This single-center study is aimed to show the feasibility and safety of percutaneous patent ductus arteriosus (PDA) closure under echocardiography-only guidance during our 1-year experience.MethodsPatients with PDA were recruited for percutaneous PDA closure guided by either fluoroscopy or echocardiography-only in National Cardiovascular Center Harapan Kita (ClinicalTrials.gov Identifier: NCT05321849, clinicaltrials.gov/ct2/show/NCT05321849). Patients were evaluated clinically and radiologically using transthoracic echocardiography (TTE) at 6, 24, and 48 h after the procedure. The primary endpoint was the procedural success. Secondary endpoints were the procedural time and the rate of adverse events.ResultsA total of 60 patients underwent transcatheter PDA closure, 30 patients with fluoroscopy and 30 patients with echocardiography guidance. All patients had successful PDA closure. There were only residual shunts, which were disappeared after follow-up in both groups, but one patient with a fluoroscopy-guided procedure had moderate tricuspid regurgitation with suspected thrombus in the tricuspid valve. The procedural time was not significantly different between the fluoroscopy and echocardiography groups.
Comparative Risks of Fracture Among Direct Oral Anticoagulants and Warfarin: A Systematic Review and Network Meta-Analysis
Authors: Tsai Sung Huang Laurent , Hu Ching-Wei , Shao Shih-Chieh , Tischler Eric H. , Obisesan Olufunmilayo H. , Vervoort Dominique , Chen Wei Cheng , Hu Jiun-Ruey , Kuo Liang-Tseng 
Published: May 2022

ImportancePrevious studies have shown the effectiveness and safety of direct oral anticoagulants (DOACs), including lower fracture risks, compared to warfarin. However, direct or indirect comparisons between different DOACs are scarce in the literature.ObjectiveThis study aims to compare fracture risks among different DOACs and warfarin, including apixaban, rivaroxaban, dabigatran, and edoxaban, in patients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE).MethodsWe searched PubMed/MEDLINE, Embase, Cochrane CENTRAL, and Web of Science for randomized controlled trials and cohort studies comparing the fracture risks among patients who used warfarin or DOACs, up to March 2021. Two authors extracted data and appraised the risk of bias of included studies. The primary outcome was fracture risk. We performed pairwise meta-analyses to compare differences between medications and network meta-analyses using frequentist random-effects models to compare through indirect evidence. We used surface under the cumulative ranking curve (SUCRA) and mean ranks to determine the probability of a DOAC ranking best in terms of fracture risk.ResultsThirty-one studies were included in the final analysis. Twenty-four randomized controlled trials and seven cohort studies with 455,343 patients were included in the systematic review and network meta-analysis. Compared to warfarin, the risk of any fractures was lowest with apixaban [relative risk (RR) = 0.59; 95% confidence interval (CI): 0.48–0.73], followed by rivaroxaban (RR: 0.72; 95% CI: 0.60–0.86), edoxaban (RR: 0.88; 95% CI: 0.62–1.23), and dabigatran (RR = 0.90; 95% CI: 0.75–1.07). No substantial inconsistency between direct and indirect evidence was detected for all outcomes.ConclusionsAll DOACs were safer than warfarin concerning the risk of fracture; however, apixaban had the lowest relative risk of fracture within the class of DOACs. Further head-to-head prospective studies should confirm the comparative safety profiles of DOACs regarding fractures.
Preliminary Study on Post-Peak Behavior and Fracture Characteristics of Hard Rock Under True Triaxial Stress
Authors: Zeng Feng , Gao Meiben , Chen Fujiang , Yang Yongyi , Zhang Yan 
Published: May 2022

The post-peak behavior and fracture characteristics of hard rock are correlated with the stability and bearing capacity of engineering rock mass. However, there are relatively few research studies on the post-peak mechanical behavior and fracture characteristics of hard rock under true triaxial stress. Therefore, this study carried out relevant true triaxial compression tests and acoustic emission (AE) monitoring. It is concluded that under a true triaxial condition, the number of post-peak steps increases first and then decreases with the increasing σ2, which implies that the rock failure evolves from shear failure to a more complex tension–shear mixed failure and finally evolves into a failure mode dominated by tensile failure. The overall level of the rock fracture angle (θ) at low σ3 is higher than that at high σ3. In the range of stress level in this study, when σ3 is high, the fracture angle of granite increases with increasing σ2, and its regularity is obvious, while when σ3 is low, the regularity of the fracture angle increases with the increasing σ2 is not obvious. It is found that there are three different types of cracking processes in granite. Meanwhile, the expansion rates of three different racking types are calculated by simplified treatment, which are about the order of 10−5–10–4 m/s. The research results of this study could supply a useful reference for the understanding of deep hard rock fracture behavior.
Validation of Aeroelastic Actuator Line for Wind Turbine Modelling in Complex Flows
Authors: Hodgson Emily L. , Grinderslev Christian , Meyer Forsting Alexander R. , Troldborg Niels , Sørensen Niels N. , Sørensen Jens N. , Andersen Søren J. 
Published: May 2022

The actuator line method is a widely used technique to model wind turbines in computational fluid dynamics, as it significantly reduces the required computational expense in comparison to simulations using geometrically resolved blades. Actuator line coupled to an aeroelastic solver enables not only the study of detailed wake dynamics but also aeroelastic loads, flexible blade deformation and how this interacts with the flow. Validating aeroelastic actuator line predictions of blade loading, deflection and turbine wakes in complex inflow scenarios is particularly relevant for modern turbine designs and wind farm studies involving realistic inflows, wind shear or yaw misalignment. This work first implements a vortex-based smearing correction in an aeroelastic coupled actuator line, and performs a grid resolution and smearing parameter study which demonstrates significant improvement in the blade loading and in the numerical dependencies of predicted thrust and power output. A validation is then performed using a 2.3 MW turbine with R = 40 m radius, comparing against blade resolved fluid-structure interaction simulations and full-scale measurement data, in both laminar and turbulent inflows including both high shear and high yaw misalignment. For an axisymmetric laminar inflow case, the agreement between blade resolved and actuator line simulations is excellent, with prediction of integrated quantities within 0.2%. In more complex flow cases, good agreement is seen in overall trends but the actuator line predicts lower blade loading and flapwise deflection, leading to underpredictions of thrust by between 5.3% and 8.4%. The discrepancies seen can be attributed to differences in wake flow, induction, the reliance of the actuator line on the provided airfoil data and the force application into the computational domain. Comparing the wake between coupled actuator line and blade resolved simulations for turbulent flow cases also shows good agreement in wake deficit and redirection, even under high yaw conditions. Overall, this work validates the implementation of the vortex-based smearing correction and demonstrates the ability of the actuator line to closely match blade loading and deflection predictions of blade resolved simulations in complex flows, at a significantly lower computational cost.
Design and Validation of Reversing Assistant Based on Extreme Learning Machine
Authors: Di Huanyu , Yan Yipeng , Zhao Mingxin , Kang Mingxin 
Published: May 2022

As an important function of the advanced driver assistance system (ADAS), the reversing assistant (RA) achieves trajectory retracing by applying accurate position estimation and tracking control. To overcome the problem of the modeling complexity in dead reckoning for the reversing assistant function, the heading angular rate is compensated by using the extreme learning machine (ELM) to improve the positioning accuracy. In addition, considering the time delay of the steering system, a tracking controller with a feed-forward of the recorded steering angle and a self-tuning PID feedback controller is designed based on the preview-and-following scheme. Vehicle experiments under various reversing scenarios prove that the proposed positioning method and tracking control scheme are effective, the overall lateral error is less than 10 cm, and the heading angle error is less than 1°, which meets the requirements of performance indicators.