bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlations Between Giant Undulations and Plasmapause Configurations
Authors: Zhou Yi‐Jia , He Fei , Yao Zhong‐Hua , Wei Yong , Zhang Xiao‐Xin , Zhang Yong‐Liang 
Published: June 2022

AbstractIn this letter, we report the correlations between giant undulations (GUs) and plasmapause (PP) configurations based on GUs' images and corresponding PP crossings of satellites between 2005 and 2019. Typically, GUs occur when the plasmasphere is eroded to form a thin and sharp PP during the storm main phase and early recovery phase. The thicknesses of the PP are usually comparable with the azimuthal wavelengths of the GUs and are smaller than the radial amplitudes of the GUs. The amplitudes and wavelengths are quasi‐proportional to the thicknesses of the PP and are inversely quasi‐proportional to the ion density gradients around the PP. The radial centers of GUs are typically aligned with the PP surfaces and their radial geocentric locations show positive correlations for different geomagnetic storms. These results would provide both physical insights and model constrains on the magnetosphere‐plasmasphere‐ionosphere energy coupling and the generation mechanisms of the GUs and plasmapause surface waves.
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
Authors: Houshmand Mohammad , Vitale Nicoletta , Orso Francesca , Cignetti Alessandro , Molineris Ivan , Gaidano Valentina , Sainas Stefano , Giorgis Marta , Boschi Donatella , Fava Carmen , Passoni Alice , Gai Marta , Geuna Massimo , Sora Federica , Iurlo Alessandra , Abruzzese Elisabetta , Breccia Massimo , Mulas Olga , Caocci Giovanni , Castagnetti Fausto , Taverna Daniela , Oliviero Salvatore , Pane Fabrizio , Lolli Marco Lucio , Circosta Paola , Saglio Giuseppe 
Published: June 2022

AbstractThe development of different generations of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has led to the high overall survival of chronic myeloid leukemia (CML) patients. However, there are CML patients who show resistance to TKI therapy and are prone to progress to more advanced phases of the disease. So, implementing an alternative approach for targeting TKIs insensitive cells would be of the essence. Dihydroorotate dehydrogenase (DHODH) is an enzyme in the de novo pyrimidine biosynthesis pathway that is located in the inner membrane of mitochondria. Here, we found that CML cells are vulnerable to DHODH inhibition mediated by Meds433, a new and potent DHODH inhibitor recently developed by our group. Meds433 significantly activates the apoptotic pathway and leads to the reduction of amino acids and induction of huge metabolic stress in CML CD34+ cells. Altogether, our study shows that DHODH inhibition is a promising approach for targeting CML stem/progenitor cells and may help more patients discontinue the therapy.
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway
Authors: Roy Sanjit K. , Ma Yiming , Lam Bao Q. , Shrivastava Anju , Srivastav Sudesh , Shankar Sharmila , Srivastava Rakesh K. 
Published: June 2022

AbstractMost cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade apoptosis. However, pancreatic cancer cells switch to glutamine metabolism to survive under hypoxic conditions. Activation of the Wnt/β-catenin pathway induces aerobic glycolysis by activating enzymes required for glucose metabolism and regulating the expression of glutamate transporter and glutamine synthetase. The results demonstrate that riluzole inhibits pancreatic cancer cell growth and has no effect on human pancreatic normal ductal epithelial cells. RNA-seq experiments identified the involvement of Wnt and metabolic pathways by riluzole. Inhibition of Wnt-β-catenin/TCF-LEF pathway by riluzole suppresses the expression of PDK, MCT1, cMyc, AXIN, and CyclinD1. Riluzole inhibits glucose transporter 2 expression, glucose uptake, lactate dehydrogenase A expression, and NAD + level. Furthermore, riluzole inhibits glutamate release and glutathione levels, and elevates reactive oxygen species. Riluzole disrupts mitochondrial homeostasis by inhibiting Bcl-2 and upregulating Bax expression, resulting in a drop of mitochondrial membrane potential. Finally, riluzole inhibits pancreatic cancer growth in KPC (Pdx1-Cre, LSL-Trp53R172H, and LSL-KrasG12D) mice. In conclusion, riluzole can inhibit pancreatic cancer growth by regulating glucose and glutamine metabolisms and can be used to treat pancreatic cancer.
Sleep disorders, mental health, and dry eye disease in South Korea
Authors: An Youngju , Kim Hyojin 
Published: June 2022

AbstractDry eye disease (DED) is a multifactorial disease of the ocular surface causing severe discomfort, mild ocular irritation, fatigue, pain, visual disturbance, and foreign body sensation. Stress, depression, and sleep disorders are risk factors for DED. We aimed to investigate the association between DED symptoms and composite factors related to mental health (combined sleep duration, psychological stress perception, and history of depressed mood) in Korean adults aged ≥ 20 years in a population-based study using the 2010–2012 Korea National Health and Nutrition Examination Survey data. Symptoms of DED and data on mental health were obtained using questionnaires. Multiple logistic regression analysis was conducted to examine the association between mental health and DED, and adjusted for possible covariates. Subjects with symptoms of DED were more likely to experience short sleep duration, psychological stress perception, and a history of depressed mood [odds ratio (OR) = 1.42, 95% confidence interval (CI) 1.06–1.90; OR = 1.71, 95% CI 1.37–2.14; and OR = 1.37, 95% CI 1.06–1.77, respectively] even after correcting for demographic factors, lifestyle factors, and medical factors. Additionally, participants with symptoms of DED were more likely to experience composite factors related to mental health (OR = 1.91, 95% CI 1.07–3.39). Therefore, ophthalmologists may report difficulties in both sleep and mental health in patients with DED.
cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer
Authors: Kabashima Ayano , Matsuo Yuki , Ito Saki , Akiyama Yoshimitsu , Ishii Takeshi , Shimada Shu , Masamune Atsushi , Tanabe Minoru , Tanaka Shinji 
Published: June 2022

AbstractImmune checkpoint blockade (ICB) treatment improves the prognosis of several types of solid tumors, however, responsiveness to ICB therapy remains low in pancreatic ductal adenocarcinoma (PDACs), which has a rich tumor microenvironment (TME). The TME is composed of various stromal cells, including cancer-associated fibroblasts (CAFs), which contribute to the establishment of an immunosuppressive microenvironment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an innate immune pathway that results in the upregulation of immune cell recruiting-cytokines and anti-tumor efficacy. In this study, we aimed to investigate the impact of cGAS-STING expression and the presence of CAFs upon immune cell infiltration in PDACs. cGAS and STING co-expressing PDAC cases showed favorable survival, with many cytotoxic CD8 + T cell infiltrations from the stromal component adjacent to the cancer cells toward cancer cells, but not in cGAS-STING signaling defected PDAC cases. The signatures of tumor-restrain CAFs were expressed in tumors with cGAS-STING signaling. Finally, transwell co-culture experiments demonstrated that immune cell infiltration was impeded by the presence of CAFs, but not by activation of cGAS-STING signaling. In conclusion, pro-infiltration signals, such as cGAS-STING, and characterization of CAFs are crucial in defeating CAF barricades and encouraging immune cell infiltration in PDACs.
Nanoscale plasmonic wires with maximal figure of merits as a superior flexible transparent conducting electrode for RGB colors
Authors: Chung Chin-Chien , Su Dong-Sheng , Huang Tsung-Yu , Lee Cheng-Yi , Visser Robert Jan , Kwak B. Leo , Bang Hyunsung , Chen Chung-Chia , Lin Wan-Yu , Yen Ta-Jen 
Published: June 2022

AbstractBased on incredibly increasing applications in modern optoelectronic devices, the demand for securing a superior conductive transparent electrode (TCE) candidate becomes significant and urgent. However, boosting both transmittance and conductance simultaneously is an intrinsic limitation. In this work, we present silver nanoscale plasmonic wires (Ag NPWs) to function as TCEs in the visible light region by lowering their corresponding plasma frequencies. By carefully designing geometric dimensions of the Ag NPWs, we also optimize the performance for red, green, and blue colors, respectively. The demonstrated figure of merits for RGB colors appeared respectively 443.29, 459.46, and 133.78 in simulation and 302.75, 344.11, and 348.02 in experiments. Evidently, our Ag NPWs offer much greater FoMs beyond conventional TCEs that are most frequently comprised of indium tin oxide and show further advantages of flexibility and less Moire effect for the applications of flexible and high-resolution optoelectronic devices.
Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance
Authors: Balkrishna Acharya , Sinha Sandeep , Srivastava Jyotish , Varshney Anurag 
Published: June 2022

AbstractWithania somnifera (L.) Dunal (Ashwagandha) is widely used in Ayurveda, Unani and Siddha systems of medicines due to its therapeutic application in numerous ailments. Traditionally, the medications prepared from the plant employ only its roots and based on the currently available scientific literature, their efficacy and safety is well established. Apart from the roots, the aerial parts also contain bioactive components and correspondingly certain marketed preparations also employ the leaves of the plant. Accordingly, Ministry of Ayush, Government of India has lately issued an advisory emphasizing the need for extensive efficacy and safety profiling of leaf-based products. Consequently, we have conducted the present GLP-driven study, in which the non-clinical safety of a hydromethanolic extract of the whole plant of Withania somnifera (WSWPE) has been assessed according to OECD guideline 407. In this study Sprague Dawley rats of either sex were orally administered with WSWPE for 28-consecutive days at the doses of 100, 300 and 1000 mg/kg/day. The study also included a satellite group of animals that received WSWPE for 28-days followed by a 14-days recovery period. Withania somnifera Whole Plant Extract was found to be safe up to the dose level of 1000 mg/kg/day as no toxicologically relevant findings could be detected.
Dysbiosis of fish gut microbiota is associated with helminths parasitism rather than exposure to PAHs at environmentally relevant concentrations
Authors: Colin Yannick , Molbert Noëlie , Berthe Thierry , Agostini Simon , Alliot Fabrice , Decencière Beatriz , Millot Alexis , Goutte Aurélie , Petit Fabienne 
Published: June 2022

AbstractAlthough parasite infection and pollution are common threats facing wild populations, the response of the gut microbiota to the joint impact of these stressors remains largely understudied. Here, we experimentally investigated the effects of exposure to Polycyclic Aromatic Hydrocarbons (PAHs) and infection by a common acanthocephalan intestinal parasite (Pomphorhynchus sp.) on the gut microbial flora of a freshwater fish, the European chub (Squalius cephalus). Naturally infected or uninfected individuals were exposed to PAHs at environmentally realistic concentrations over a five-week period. Characterization of the gut bacterial community through 16S rRNA gene amplicon sequencing revealed that parasitic infection was a more structuring factor of bacterial diversity and composition than PAH exposure. Specifically, chub infected by Pomphorhynchus sp. harbored significantly less evenly represented gut bacterial communities than the uninfected ones. In addition, substantial changes in sequence abundance were observed within the main bacterial phyla, including the Firmicutes, Fusobacteriota, Actinobacteriota, and Proteobacteria. Again, these compositional changes correlated with host infection with Pomphorhynchus sp., confirming its pivotal role in gut microbial assemblage. Overall, these results highlight the importance of defining the parasitic status of individuals when conducting microbial ecotoxicological analyses at the digestive tract level, as this should lead to better understanding of microbiota modulations and help to identify microbial markers specifically associated with chemicals.
Comparative effectiveness of low-dose-rate brachytherapy with or without external beam radiotherapy in favorable and unfavorable intermediate-risk prostate cancer
Authors: Tsumura Hideyasu , Tanaka Nobumichi , Oguchi Tomohiko , Owari Takuya , Nakai Yasushi , Asakawa Isao , Iijima Kazuyoshi , Kato Haruaki , Hashida Iwao , Tabata Ken-ichi , Satoh Takefumi , Ishiyama Hiromichi 
Published: June 2022

AbstractWe compared clinical outcomes associated with seed brachytherapy (SEED-BT) alone and SEED-BT plus external-beam radiotherapy (EBRT) for intermediate-risk prostate cancer using propensity score-matched analysis. From 2006 to 2011, 993 patients diagnosed with intermediate-risk were treated with either SEED-BT alone (n = 775) or SEED-BT plus EBRT (n = 158) at 3 tertiary hospitals. In the propensity score-matched analysis (102 pairs), median follow-up was 95 months (range 18–153 months). The 8-year biochemical recurrence-free rate (bRFR) was significantly better with SEED-BT alone than with combined radiotherapy (93.3% vs. 88.4%; HR 0.396; 95% CI 0.158–0.991). Grade 2 or greater late genitourinary toxicities were significantly fewer with SEED-BT alone than with combined radiotherapy (21.0% vs. 33.2%; HR 0.521; 95% CI 0.308–0.881). Similarly, grade 2 or greater late gastrointestinal toxicities were significantly fewer with SEED-BT alone (0% vs. 12.2%; HR 0.125; 95% CI 0.040–0.390). For the unfavorable intermediate-risk subgroups, SEED-BT alone yielded a significantly better bRFR than the combined radiotherapy (HR 0.325; 95% CI 0.115–0.915). SEED-BT alone might be a better disease-management plan than SEED-BT plus EBRT for intermediate-risk prostate cancer regardless of favorable and unfavorable characteristics.
Mito-nuclear coevolution and phylogenetic artifacts: the case of bivalve mollusks
Authors: Formaggioni Alessandro , Plazzi Federico , Passamonti Marco 
Published: June 2022

AbstractMito-nuclear phylogenetic discordance in Bivalvia is well known. In particular, the monophyly of Amarsipobranchia (Heterodonta + Pteriomorphia), retrieved from mitochondrial markers, contrasts with the monophyly of Heteroconchia (Heterodonta + Palaeoheterodonta), retrieved from nuclear markers. However, since oxidative phosphorylation nuclear markers support the Amarsipobranchia hypothesis instead of the Heteroconchia one, interacting subunits of the mitochondrial complexes ought to share the same phylogenetic signal notwithstanding the genomic source, which is different from the signal obtained from other nuclear markers. This may be a clue of coevolution between nuclear and mitochondrial genes. In this work we inferred the phylogenetic signal from mitochondrial and nuclear oxidative phosphorylation markers exploiting different phylogenetic approaches and added two more datasets for comparison: genes of the glycolytic pathway and genes related to the biogenesis of regulative small noncoding RNAs. All trees inferred from mitochondrial and nuclear subunits of the mitochondrial complexes support the monophyly of Amarsipobranchia, regardless of the phylogenetic pipeline. However, not every single marker agrees with this topology: this is clearly visible in nuclear subunits that do not directly interact with the mitochondrial counterparts. Overall, our data support the hypothesis of a coevolution between nuclear and mitochondrial genes for the oxidative phosphorylation. Moreover, we suggest a relationship between mitochondrial topology and different nucleotide composition between clades, which could be associated to the highly variable gene arrangement in Bivalvia.
Comparison of angiographic outcomes and complication rates of WEB embolization and coiling for treatment of unruptured basilar tip aneurysms
Authors: Celik Erkan , Ozpeynirci Yigit , Liebig Thomas , Schlamann Marc , Dorn Franziska , Lehnen Nils , Siebert Eberhard , Goertz Lukas , Kabbasch Christoph 
Published: June 2022

AbstractEndovascular coiling represents the standard treatment for basilar tip aneurysms. Some of these aneurysms are not amenable to conventional coiling due to a complex aneurysm geometry, hence, novel devices such as the Woven Endobridge (WEB) have been developed. We retrospectively compared WEB embolization and coiling for the treatment of unruptured basilar tip aneurysms. Patients treated with WEB or coiling at four centers were reviewed. Procedure-related complications, clinical outcome and angiographic results were retrospectively evaluated and compared. Forty patients treated with the WEB and 35 patients treated by coiling were included. Stent-assistance was more often necessary for coiling than for WEB embolization (71% vs 2.5%, p < 0.001). The technical success rates were 100% for both methods. The overall complication rates were not significantly different between groups (WEB: 5%, coil: 11%, p = 0.409). Procedural morbidity rates were 9% in the coiling group and 2.5% in the WEB group (p = 0.334). There was no mortality. Treatment duration was shorter for WEB implantation than for coiling (p = 0.048). At mid-term follow-up, complete occlusion, neck remnants and aneurysm remnants were observed in 89%, 4% and 7% for the WEB, respectively, and in 100%, 0% and 0% for coiling. While complication rates and mid-term angiographic outcome was comparable between the groups, the WEB was associated with a shorter treatment duration and required stent-assistance less frequently. The choice of the treatment modality should be made based on the specific aneurysm characteristics, the individual experience of the neurointerventionalist and patient preference.
Radiative flow of viscous nano-fluid over permeable stretched swirling disk with generalized slip
Authors: Hussain Mazhar , Rasool Mudassar , Mehmood Ahmer 
Published: June 2022

AbstractIn present years, the study of nanofluids has emerged as a hot topic among the researchers, because the nanoparticle contained in the fluids significantly enhances the heat transfer properties of the fluids. Particularly, rotating ows are of vital importance due to their wide range of scientific, engineering applications, such as jet engines, pumps and vacuum cleaners, as well as geophysical ows. In this study water based nanofluid over radially stretchable rotating disk in the presence of radiation heat transfer is considered. The surface of the stretchable rotating disk surface allows the impact of continuous suction and admits the generalized slip. The Tiwari and Das model is used to describe the nanouid behavior (Tiwari and Das in Int J Heat Mass Transf 50(9–10):2002–2018, 2007). Three types of nanoparticles: Copper (Cu), silver (Ag) and titanium dioxide $$(TiO_2)$$

(
T
i

O
2

)

are taken into account. By choosing an appropriate set of similarity transformations, the boundary layer momentum equations and energy equation are transformed to set of nonlinear ordinary differential equations. The impact of emerging quantities like, nanoparticle concentration $$\phi $$
ϕ
, suction parameter $$w_{\circ }$$

w
∘

, slip parameters $$\zeta $$
ζ
, critical shear stress parameter $$\beta $$
β
, and radiation parameter $$N_{rd}$$

N

rd

, are illustrated through several graphs and tables. The Nusselt number and skin friction coefficient are also calculated to analyze the heat transfer process.
Superhydrophobic magnetic sorbent via surface modification of banded iron formation for oily water treatment
Authors: Farahat Mohsen , Sobhy Ahmed , Sanad Moustafa M. S. 
Published: June 2022

AbstractIn the current study, a simple dry coating method was utilized to fabricate a super-hydrophobic super-magnetic powder (ZS@BIF) for oily water purification using zinc stearate (ZS) and banded iron formation (BIF). The produced composite was fully characterized as a magnetic sorbent for oily water treatment. The results of X-ray diffraction diffractometer (XRD), Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS) and particle size analysis revealed the fabrication of homogenous hydrophobic-magnetic composite particles with core–shell structure. Contact angle and magnetic susceptibility results showed that 4 (BIF): 1 (Zs) was the ideal coverage ratio to render the core material superhydrophobic and preserve its ferromagnetic nature. The capability of the fabricated composite to sorb. n-butyl acetate, kerosene, and cyclohexane from oil–water system was evaluated. ZS@BIF composite showed a higher affinity to adsorb cyclohexane than n-butyl acetate and kerosene with a maximum adsorption capacity of about 22 g g−1 and 99.9% removal efficiency. Moreover, about 95% of the adsorbed oils could be successfully recovered (desorbed) by rotary evaporator and the regenerated ZS@BIF composite showed high recyclability over ten repeated cycles.
Human placental extract activates a wide array of gene expressions related to skin functions
Authors: Chang Phooi-Yee , Chin Lit-Chein , Kimura Koichi , Nakahata Yasukazu 
Published: June 2022

AbstractAs skin aging is one of the most common dermatological concerns in recent years, scientific research has promoted treatment strategies aimed at preventing or reversing skin aging. Breakdown of the extracellular matrix (ECM), such as collagen and elastin fibers, in the skin results in decreased skin elasticity and tension. Cutaneous cells, especially fibroblasts in the dermis layer of the skin, mainly produce ECM proteins. Although clinical studies have demonstrated that placental extract (PE) has positive effects on skin health, the molecular mechanisms by which PE acts against skin aging are still largely unknown. In this study, we performed RNA-sequence analysis to investigate whether human PE (HPE) alters ECM-related gene expression in normal human dermal fibroblast (NHDF) cells. Gene ontology analysis showed that genes related to extracellular matrix/structure organization, such as COL1A1, COL5A3, ELN, and HAS2 were highly enriched, and most of these genes were upregulated. We further confirmed that the HPE increased the type I collagen, proteoglycan versican, elastin, and hyaluronan levels in NHDF cells. Our results demonstrate that HPE activates global ECM-related gene expression in NHDF cells, which accounts for the clinical evidence that the HPE affects skin aging.