bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Smoothed Particle Hydrodynamics (SPH) for the Simulation of Flow-like Landslides on 3D Terrains
Authors: Cui Binghui , Zhang Liaojun 
Published: January 2022

Abstract
Flow-type landslide is one type of landslide that generally exhibits characteristics of high flow velocities, long jump distances, and poor predictability. Simulation of it facilitates propagation analysis and provides solutions for risk assessment and mitigation design. The smoothed particle hydrodynamics (SPH) method has been successfully applied to the simulation of two-dimensional (2D) and three-dimensional (3D) flow-like landslides. However, the influence of boundary resistance on the whole process of landslide failure is rarely discussed. In this study, a boundary algorithm considering the friction is proposed, and integrated into the boundary condition of the SPH method, and its accuracy is verified. Moreover, the Navier-Stokes equation combined with the non-Newtonian fluid rheology model was utilized to solve the dynamic behavior of the flow-like landslide. To verify its performance, the Shuicheng landslide event, which occurred in Guizhou, China, was taken as a case study. In the 2D simulation, a sensitivity analysis was conducted, and the results showed that the shearing strength parameters have more influence on the computation accuracy in comparison with the coefficient of viscosity. Afterwards, the dynamic characteristics of the landslide, such as the velocity and the impact area, were analyzed in the 3D simulation. The simulation results are in good agreement with the field investigations. The simulation results demonstrate that the SPH method performs well in reproducing the landslide process, and facilitates the analysis of landslide characteristics as well as the affected areas, which provides a scientific basis for conducting the risk assessment and disaster mitigation design.
Widespread natural methane and oil leakage from sub-marine Arctic reservoirs
Authors: Serov Pavel , Mattingsdal Rune , Winsborrow Monica , Patton Henry , Andreassen Karin 
Published: January 2022

Abstract
Parceling the anthropogenic and natural (geological) sources of fossil methane in the atmosphere remains problematic due to a lack of distinctive chemical markers for their discrimination. In this light, understanding the distribution and contribution of potential geological methane sources is important. We present empirical observations of hitherto undocumented, widespread and extensive methane and oil release from geological reservoirs to the Arctic Ocean. Methane fluxes from >7,000 seeps significantly deplete in seawater, but nevertheless reach the sea surface and may transfer to the air. Oil slick emission spots and gas ebullition are persistent across multi-year observations and correlate to formerly glaciated geological structures, which have experienced km-scale glacial erosion that has left hydrocarbon reservoirs partially uncapped since the last deglaciation ~15,000 years ago. Such persistent, geologically controlled, natural hydrocarbon release may be characteristic of formerly glaciated hydrocarbon-bearing basins which are common across polar continental shelves, and could represent an underestimated source of natural fossil methane within the global carbon cycle.
Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy
Authors: Yao Junjie , Zhu Xiaoyi , Huang Qiang , DiSpirito Anthony , Vu Tri , Rong Qiangzhou , Peng Xiaorui , Sheng Huaxin , Shen Xiling , Zhou Qifa , Jiang Laiming , Hoffmann Ulrike 
Published: January 2022

Abstract
High-speed high-resolution imaging of the whole-brain hemodynamics is urgently needed to facilitate the next level of neurovascular research. Image acquisition speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks, and displaying fast pathophysiological dynamics on a micro and macro-level, enabling advances in current queries in neurovascular and brain metabolism research, including stroke, dementia and acute brain injury. Further, real-time oxygen saturation of hemoglobin (sO2) imaging to differentiate arteries from veins and capture fast-paced oxygen delivery dynamics is needed to solve pertinent questions in these fields and beyond. Here, we present a novel ultrafast functional photoacoustic microscopy (UFF-PAM) to image the whole-brain hemodynamics and oxygen delivery. UFF-PAM takes advantage of several key engineering innovations, including Raman-shifter-based dual-wavelength laser excitation, water-immersible 12-facet-polygon scanner, high-sensitivity ultrasound transducer, and deep-learning-based image upsampling. A volumetric imaging rate of 2 Hz has been achieved over a field of view (FOV) of 11× 7.5 × 1.5 mm3 with a high spatial resolution of ~10 µm. Using the UFF-PAM system, we have demonstrated proof-of-concept functional studies on the mouse brains in response to systemic hypoxia, sodium nitroprusside, and stroke. We observed the mouse brain’s fast morphological and functional changes over the entire cortex, including vasoconstriction, vasodilation, and deoxygenation. More interestingly, for the first time, under the whole-brain FOV and micro-vessel resolution, we captured the vasoconstriction and oxygenation change simultaneously in the spreading depolarization (SD) wave. Our work provides a great potential for fundamental brain research under various pathological and physiological conditions.
Concatenated Convolutional Neural Network Model for Cuffless Blood Pressure Estimation Using Fuzzy Recurrence Properties of PPG Signals
Authors: Malayeri Ali Bahari , Khodabakhshi Mohammad Bagher 
Published: January 2022

Abstract
Due to the importance of continuous monitoring of blood pressure (BP) in controlling hypertension, the topic of cuffless blood pressure (BP) estimation has been widely studied in recent years. A most important approach is to explore the nonlinear mapping between the recorded peripheral signals and the BP values which is usually conducted by deep neural networks. Because of the sequence-based pseudo periodic nature of peripheral signals such as photoplethysmogram (PPG), a proper estimation model needed to be equipped with the 1-dimensional (1-D) and recurrent layers. This, in turn, limits the usage of 2-dimensional (2-D) layers adopted in convolutional neural networks (CNN) for embedding spatial information in the model. In this study, considering the advantage of chaotic approaches, the recurrence characterization of peripheral signals was taken into account by a visual 2-D representation of PPG in phase space through fuzzy recurrence plot (FRP). FRP not only provides a beneficial framework for capturing the spatial properties of input signals but also creates a reliable approach for embedding the pseudo periodic properties to the neural models without using recurrent layers. Moreover, this study proposes a novel deep neural network architecture that combines the morphological features extracted simultaneously from two upgraded 1-D and 2-D CNNs capturing the temporal and spatial dependencies of PPGs in systolic and diastolic BP estimation. The model has been fed with the 1-D PPG sequences and the corresponding 2-D FRPs from two separate routes. The performance of the proposed framework was examined on the well-known public dataset, namely, Multi-Parameter Intelligent in Intensive Care II. Our scheme is analyzed and compared with the literature in terms of the requirements of the standards set by the British Hypertension Society (BHS) and the Association for the Advancement of Medical Instrumentation (AAMI). The proposed model met the AAMI requirements, and it achieved a grade of A as stated by the BHS standard. In addition, its mean absolute errors (MAE) and standard deviation for both systolic and diastolic blood pressure estimations were considerably low, 3.05±5.26 mmHg and 1.58±2.6 mmHg, in turn.
Estimating The Distribution of Livestock In Space And Time: A Time-Series Contribution To Livestock Density Mapping
Authors: Meisner Julianne , Kato Agapitus , Lemerani Marshall , Miaka Erick Mwamba , Taban Acaga Ismail , Wakefield Jonathan , Rowhani-Rahbar Ali , Pigott David , Mayer Jonathan , Rabinowitz Peter 
Published: January 2022

Abstract
More than one billion people rely on livestock for income, nutrition, and social cohesion, however livestock keeping can facilitate disease transmission and contribute to climate change. While data on the distribution of livestock thus have broad utility across a range of applications, efforts to map the distribution of livestock on a large scale are limited to the Gridded Livestock of the World (GLW) project. We present a complimentary effort to map the distribution of cattle and pigs in Malawi, Uganda, Democratic Republic of Congo (DRC), and South Sudan. In contrast to GLW, which uses dasymmetric modeling applied to census data to produce time-stratified estimates of livestock counts and spatial density, our work uses complex survey data and distinct modeling methods to generate a time-series of livestock distribution, defining livestock density as the ratio of animals to humans. In addition to favorable cross-validation results and general agreement with national density estimates derived from external data on national human and livestock populations, our results demonstrate extremely good agreement with GLW-3 estimates, supporting the validity of both efforts. Our results furthermore offer a high-resolution time series result and employ a definition of density which is particularly well-suited to the study of livestock-origin zoonoses.
Bacteriophages in Gut Microbiome Interactions in Patients with Inflammatory Bowel Disease: Differences by Sex and The Disease Type
Authors: Farahmandzad Fatemeh , Lanjanian Hossein , Arefian Ehsan , Kavousi Kaveh 
Published: January 2022

Abstract
Background: Inflammatory bowel disease (IBD), known as the disease of the century, is a complex condition that affects millions of people worldwide. IBD is influenced by numerous factors such as genetics, lifestyle, and the gut microbial community, yet the role of microorganisms in driving and controlling the disease remains poorly understood. As we know, preceding studies have mainly focused on assessing gut bacteria and less on bacteriophages or fungi, and no study on interactions of the gut microbial community in patients with IBD has looked at bacteriophages in addition to bacteria and fungi by sex. No distinct microbial regulatory candidate has been proposed so far.Results: Here, metagenomic data were obtained from 456 stool samples of 84 white race volunteers (40 females and 44 males) with no treatment history before sampling. Participants were studied by sex and the disease type using bioinformatics methods. Differences in interactions of bacteriophages, bacteria, fungi, and archaea in the gut of males and females with Crohn's disease were remarkable, indicating the necessity for different therapies for both groups. While, little difference was seen in the gut microbiome relations in females and males with ulcerative colitis.Conclusions: The fungal strain Malassezia globose CBS 7966 beside the bacterial species Bacteroides stercorisin ulcerative colitis and Parabacteroides phage YZ-2015b in Crohn's disease were the sex-independent regulatory candidates. Uncultured crAssphage was recommended as a sex-dependent regulatory candidate for IBD in men. However, the fungus Wickerhamomycesciferrii which had proposed as regulatory candidate in Crohn's disease, was age-dependent in females. Four bacteriophages, such as Escherichia phage pro147, were suggested for study candidates in the metabolism of IBD.
Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region
Authors: Sumin Alexey N. , Gomozova Nina S. , Shcheglova Anna V. , Arkhipov Oleg G. 
Published: January 2022

Abstract
Objective
of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region.
Methods
The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38), non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied.
Results
Shor men with arterial hypertension had the lowest values ​​of the pulmonary artery index, the right atrium dimensions, and the highest values ​​of the blood flow velocity in the right ventricle, et' and st' in comparison with non-indigenous men. Shor women have the lowest values Et and Et/At ratios. RV diastolic dysfunction was detected mainly in women, somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence. Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase).
Conclusion
Our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.
Assistive Technology to Promote Participation in Sport for People with Disabilities
Authors: Geppert Ana , Smith Emma M. , Haslett Damian , Wong Jennie , Ebuenyi Ikenna D. , Noske-Turner Jessica , MacLachlan Prof. Malcom 
Published: January 2022

Abstract
Participation in sports is a fundamental right for persons with disabilities and is facilitated by the use of specialized Assistive Technology (AT). However, little is known about the role every-day AT plays in promoting sport participation. This study explores how the 50 priority assistive products on the World Health Organization’s Assistive Products List can promote participation in sports, using a mixed-methods online survey with AT users, caregivers, and coaches (n=96). We used a thematic analysis for qualitative responses describing the use of assistive products in facilitating sport participation. Results suggest every-day assistive products are required for participation in sport for persons with disabilities. We present a conceptual model of assistive product use for sport participation. We found persons with disability participate in a range of sports, contributing to community engagement. Access to every-day assistive products is therefore integral to achieving rights of persons with disabilities for participation in sport.
Use and alternatives to coercive measures in inpatient residential care facilities for adults with disabilities: study protocol of a mixed-methods study
Authors: Klemmt Malte , Brieger Peter , Schmitt-Schäfer Thomas , Mörtz Annika , Henking Tanja 
Published: January 2022

Abstract
BackgroundIn Germany, the use of coercive measures such as physical or chemical restraints in certain settings has been the focus of high court decisions, political debates, and scientific research in areas like psychiatric care. Such encroachments on fundamental rights could easily be overlooked in the case of residents in inpatient residential care facilities for adults with disabilities. However, little data are available on this issue. This study aims to investigate the types, frequencies, and characteristics of the use of coercive measures as well as the reasons and justifications of their use. Possible alternatives to these measures and contextual conditions will also be identified.MethodsThe study is based on an explorative, multi-phase, cross-sectional design, which consists of a mixed-methods approach including several forms of data collection and analysis bringing together forensic, sociological, pedagogical and medical perspectives and expertise. First, the entirety of the approximately n = 880 residential care facilities for adults with disabilities in the study area will be surveyed by an online questionnaire. Participating passive observations will be carried out in n = 5 selected residential care facilities (24 hours per facility), with an approximate total of n = 150 residents. In these facilities, organizational documents such as house rules and residential documents such as medication plans will also be collected and analysed. Focus groups will be conducted in each of the five facilities including residents, staff, and legal guardians of the residents.DiscussionThis study will address important gaps in the current research by providing different forms of empirical data on the use or avoidance, causes, contexts, and alternatives to coercive measures in inpatient residential care facilities for adults with disabilities. This study is the first in Germany to combine a general overview (survey) and detailed insight (observations, document analysis, focus groups) approach to this issue. These findings will provide a basis for further research in the field as well as for the management of coercive measures in practical settings.
Effects of HCl hydrolyzed cellulose nanocrystals from waste papers on the Hydroxypropyl methylcellulose/Cationic Starch biofilms
Authors: vaezi khashayar , Asadpour Ghasem 
Published: January 2022

Abstract
ABSTRACT
The study reports on the preparation of nanocrystalline cellulose from waste papers (WPNCC), as an environmental friendly approach of source material and investigation of their effects on the morphological, mechanical and barrier properties of the Hydroxypropyl methylcellulose/Cationic starch (HPMC/CS) nanocomposites. HCl hydrolysis followed by alkali treatment and deinking of the fibers resulted in the production of WPNCC. The TEM results confirmed the rod like shape of WPNCC; the average diameter was 22± 7 nanometers and the length was 125± 25 nanometers. The hydrolysis yield was 65% with high crystallinity index of 79.6%. The results of X-ray diffraction confirmed the successfully production of WPNCC and their effective presence in the HPMC/CS matrix. The homogeneity of WPNCC dispersion in the polymer matrix was approved by FESEM analysis. The WPNCC also did not affect the nanocomposites optical clarity. The optimum amount of 9 wt% WPNCC, showed the highest barrier, mechanical and biodegradablility properties.
Modeling of Interstitial Microwave Hyperthermia for Hepatic Tumors Using Floating Sleeve Antenna
Authors: Eltigani Faihaa , Ahmed Sulafa , Yahya Maged , Ahmed Mawahib 
Published: January 2022

Abstract
PurposeMicrowave hyperthermia is a treatment modality that uses microwaves to destroy cancer cells by increasing their temperature to 41- 45°C. This study aims to design, modeling, and simulation of a microwave sleeve antenna for hepatic (liver) hyperthermia. MethodThe designed antenna resonated at 2.45 GHz. The antenna was tested in six different 3D liver models: Model A: without a tumor and blood vessels; Model B: with a realistic tumor (2x3 cm) and without blood vessels; Model C: created by adding blood vessels to model B; Model D: created by adding a small tumor (1.5x1.5 cm) to model C and changed its location; Model E: same as model C with a different tumor size; Model F: model with a simple spherical tumor (1.5x1.5 cm).ResultsThe return loss of the antenna varied from -45 dB to -25 dB for the 6 models. The Specific Absorption Rate (SAR) was between 29 W/kg to 30W/kg in the tumors and below 24 W/Kg in the surrounding tissues. The tumors’ temperature elevated to 43- 45°C, while the temperature of the surrounding tissues was below 41°C.ConclusionsThe results showed the capability of the designed antenna to raise the temperature of hepatic tumors to the therapeutic ranges of hyperthermia.
HCMV exploits STING signaling and counteracts IFN and ISG induction to facilitate dendritic cell infection
Authors: Costa Bibiana , Becker Jennifer , Krammer Tobias , Mulenge Felix , Durán Verónica , Pavlou Andreas , Chu Xiaojing , Li Yang , Cicin-Sain Luka , Eiz-Vesper Britta , Dolken Lars , Saliba Antoine-Emmanuel , Erhard Florian , Kalinke Ulrich 
Published: January 2022

Abstract
Human cytomegalovirus (HCMV) is a widespread obligatory human pathogen causing life-threatening disease in immunocompromised hosts. Myeloid cells such as monocyte-derived dendritic cells (moDCs) are targets of HCMV. Here, we performed single-cell RNA sequencing, which revealed infection of most moDCs upon in vitro HCMV exposure, whereas only a fraction of them initiated viral gene expression. We identified three moDC subsets, of which CD1a−/CD86− cells showed the highest susceptibility. Upon HCMV entry, STING activation not only induced IFN-β, but also promoted viral gene expression. Upon progression of infection, IFN-β but not IFN-λ1 expression was inhibited. Similarly, ISG expression was initially induced and then shut off and thus allowed productive infection. Increased viral gene expression was associated with the induction of several pro- (RHOB, HSP1A1, DNAJB1) and anti-viral (RNF213, TNFSF10, IFI16) genes. Thus, moDC permissiveness to HCMV depends on complex interactions between virus sensing, regulation of IFNs/ISGs and viral gene expression.
Plant based Bioavailability Enhancers
Authors: Patel Sweta , Chopra Shruti , Chaurasia Simran , Sarwat Maryam 
Published: January 2022

Abstract:
Many of the synthetic and herbal drugs, despite their notable in vitro findings, demonstrate insignificant
in vivo activity, the majority of the time due to poor bioavailability. As per Biopharmaceutical Classification
System (BCS), one of the main concerns is low solubility and/or permeation of drugs resulting in reduced
absorption and poor bioavailability. To overcome these issues, various strategies have been adopted, including
the use of permeation enhancers which are also known as bioenhancers. Bioenhancers are synthetic or natural
compounds that increase the bioavailability of drugs and nutrients such as vitamins, amino acids, minerals, etc.,
into the systemic circulation and at the site of action for exhibiting improved therapeutic action. By improving
bioavailability, bioenhancers can reduce drug dose, decrease the treatment period, and circumvent the problem
of drug resistance. Although numerous studies have reported the application of synthetic bioenhancers, plant
based bioenhancers can serve as a better alternative owing to their natural origin. Literature reviews have
revealed that plant-based bioenhancers have been used in a wide variety of antibiotics, antiviral, and anti-cancer
therapeutics. These can be categorized based on their sources and mechanism of action. This review will provide
a systematic and detailed overview of the various plant based bioenhancers and their applications.
Arylidenemalononitriles as Versatile Synthons in Heterocyclic Synthesis
Authors: Reddy Pedavenkatagari Narayana , Padmaja Pannala , Reddy B.V. Subba , Ugale Vinod G. 
Published: January 2022

Background:Arylidenemalononitriles are valuable synthons for the construction of a variety of novel complex heterocyclic motifs, fused heterocycle derivatives, and spirocyclic com-pounds. They are versatile chemical intermediates and have increasing applications in industry, agriculture, medicine, and biological science.Objective:The aim of this review is to highlight the preparation methods and reactions of aryli-denemalononitriles in the synthesis of various heterocyclic compounds.Conclusion:In this review, we have presented the application of arylidenemalononitriles to con-struct a variety of heterocycles. Various catalysts for the preparation of arylidnemalononitriles have been described.