bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Recent Advancement in Nanotechnology Approaches for the Treatment of Cervical
Cancer
Authors: Theivendren Panneerselvam , Hegde Yashoda Mariappa , Srinivas Geetha , Palanivel Monashilpa , Shanmugam Nivetha , Kunjiappan Selvaraj , Vellaichamy Sivakumar , Gopal Murugananthan , Dharmalingam Senthil Rajan 
Published: May 2022

Background:
Cervical cancer is one of the leading causes of female death, with a mortality rate of over
200,000 per year in developing countries. Despite a decrease in cervical cancer occurrences in developed countries
over the last decade, the frequency of the disease in developing nations continues to rise at an alarming rate, particularly
when it is linked to the human papillomavirus (HPV). With just a few highly invasive conventional therapies available,
there is a clear need for novel treatment options such as nanotechnology-based chemotherapeutic drug delivery.

Current limitations:
Traditional anticancer therapy is limited by poor drug potency, non-specificity, unwanted side
effects, and the development of multiple drug resistance (MDR), leading to a decrease in long-term anticancer therapeutic
efficacy. An ideal cancer therapy requires a personalized and specialized medication delivery method capable of
eradicating even the last cancer cell responsible for disease recurrence.

Purpose:
Nanotechnology provides effective drug delivery mechanisms, allowing it to serve both therapeutic and
diagnostic purposes. Nanotechnology-based formulations are widely used to accurately target the target organ, maintain
drug load bioactivity, preferentially accumulate the drug at the target location, and reduce cytotoxicity.

Future perspectives:
The key benefits of this drug delivery are that it improves pharmacological activity, solubility,
and bioavailability and reduces toxicity in the target tissue by targeting ligands, allowing for new innovative treatment
methods in an area that is desperately required. The goal of this review is to highlight possible research on nanotechnology-
based delivery systems for cancer detection and treatment.
The Glutaminase Inhibitor Compound 968 Exhibits Potent In vitro and In vivo
Anti-tumor Effects in Endometrial Cancer
Authors: Sheng Xiugui , Yuan Lingqin , Guo Hui , Li Wanhu , Pan Guoyou , Wang Cong , Li Dapeng , Liu Naifu 
Published: May 2022

Background:
Glutamine is one of the primary nutrients utilized by cancer cells for energy production and biosynthesis. Hence, interfering with glutamine metabolism may impose anti-tumor effects.

Objective:
In this study, we assessed the anti-tumorigenic effects of glutaminase-1 enzyme (GLS1) inhibition in endometrial cancer in vitro and in vivo.

Methods:
The human endometrial cancer cell lines Ishikawa and HEC-1B were used. The effects of compound 968 on cell proliferation, cell cycle, apoptosis, cellular stress, and AKT/mTOR pathway inhibition were assessed. The synergistic effects of compound 968 and paclitaxel was also analyzed. The in vivo effect of compound 968 was evaluated using tumor xenografts.

Results:
We found that the GLS1-targeting compound 968 was able to reduce cancer cell proliferation in a dose- and time-dependent manner. Compound 968 combined with low concentration of paclitaxel showed stronger inhibitory effects. Further analyses indicated that compound 968 induced cell cycle arrest at the G1 phase, as well as increased the production of cellular reactive oxygen species (ROS) and promoted cellular stress and cancer cell apoptosis. Additionally, the treatment of endometrial cancer with compound 968 downregulated the expression of GLS1 and cyclin D1, and upregulated the expression of P21 and E-cadherin. Moreover, the treatment of endometrial cancer cells with compound 968 significantly reduced levels of phospho-S6 ribosomal protein and phospho-AKT (Ser473), indicative of AKT/mTOR/S6 signaling pathway inhibition. In xenograft mouse models of endometrial cancer, compound 968 significantly suppressed tumor growth. In addition, western blotting analysis indicated that GLS1 expression was upregulated in human endometrial cancer tissues.

Conclusion:
Compound 968 may be a promising approach for the management of human endometrial cancer.
Research on Incentive Mechanism and Credit Behavior of University
Scientific Research Based on Evolutionary Game
Authors: Xuwang Liu , Yujie Zhang , Zhengxuan Zhang 
Published: May 2022

Background:
Colleges and universities are the important support of national scientific and technological innovation, and research productions are the comprehensive embodiment of their strength. How to mobilize the enthusiasm of researchers and create a good atmosphere for researchers have research value.

Objective:
On the premise of the bounded rationality of researchers, this paper first briefly describes some practical issues in the field of evaluation of scientific achievements, establishing two major research objects: researchers and scientific research management departments.

Methods:
: By using the evolutionary game theory, this study establishes a two-side evolutionary game model in combination with the factors that affect the decision of researchers, and it proves the preconditions for an evolutionarily stable strategy based on replication dynamic thought and the criterion of evolutionary stability strategy. Based on MATLAB GUI platform, this paper develops the numerical simulation system of research investment and reward strategy and realizes the quantitative processing of the theoretical model.

Results:
Firstly, the evolution speed of the researcher choosing high research investment and the scientific management department choosing high research reward strategy is related to the selection ratio of this strategy; then, there is hysteresis in both parties’ mastery of each other’s strategy information; finally, while optimizing the conditions for scientific research and punishing academic misconduct, the administrative departments should regularly adjust their assessment indicators to create a good atmosphere for scientific research

Conclusion:
This paper will further solve engineering problems in the field of scientific research management.
Therapeutic Potential of a Bioactive Flavonoids Glycitin from Glycine
max: A Review on Medicinal Importance, Pharmacological Activities and
Analytical Aspects
Authors: Patel Dinesh Kumar 
Published: May 2022

Background:
Soybean (Glycine max (L.) Merr.) is an important industrial crop and fourth major crop in the world which are the richest source of isofavones including glycitein in human diet. Soybean has been associated with beneficial effects in prevention of cancer, osteoporosis, cardiovascular diseases and menopausal symptoms. Isoflavones class phytochemicals has been extensively studied in the scientific fields due to its estrogenic potential.

Methods:
Scientific information of glycitin for their biological potential and therapeutic effects has been collected and analyzed in the present work. Scientific data of glycitin has been collected from electronic databases such as Google, Google Scholar, PubMed, Science Direct, and Scopus in the present work and analyzed for their therapeutic potential. Detailed pharmacological activities and analytical data of glycitin has been collected from these databases using term flavonoid and glycitin and analyzed.

Results:
Scientific data analysis revealed the biological importance and therapeutic benefit of glycitin in the medicine. Glycitin also called 4′-hydroxy-6-methoxyisoflavone-7-D-glucoside have been found to present in the Soy products. Glycitin exhibit chemo-preventive, cardio-protective and anti-osteoporosis effects. Glycitin revealed their beneficial effects on diabetes, acute lung injury, bone, cognitive performance, breast cancer, skin, immune system, enzymes, prostaglandin and taste receptors. However its ligand binding assay, cytoprotective effect and pharmacokinetic parameters were also studied in the present work. Analytical data signified the importance of analytical tools for qualitative and quantitative analysis of glycitin in the medicine.

Conclusion:
Scientific data analysis revealed the therapeutic effectiveness of glycitin in the medicine.
A Charging and Discharging Model for Electric Vehicles based on Consortium
Blockchain Using Multi-Objective Gray Wolf Algorithm
Authors: Li Yuancheng , Shang Xingyu , Huang Rong 
Published: May 2022

Background:
As many EVs (EVs) are connected to the grid, transactions between EVs and the grid will have problems such as poor privacy and affecting the stability of the grid. This paper uses consortium blockchain to design a safe and privacy-preserving scheme for the two-way power transaction between EVs and the grid.

Objective:
: To reduce the adverse impact of disorderly charging of large-scale EVs on the power grid, the total load variance is minimized by optimizing EVs' charging/discharging period.

Methods:
We propose to use a heuristic algorithm, an improved multi-objective gray wolf algorithm, to solve this problem.

Results:
The simulation results show that the model can effectively smooth load fluctuations and improve user benefits.

Conclusion:
Our method can effectively reduce the load fluctuation of the grid while ensuring the economic benefits of users. Qualitative security and privacy analysis show that the solution helps to improve the security and privacy of electricity transactions.
Detailed Study on Electronic Data Energy Consumption Monitoring System
Based on the Construction of Internet of Things
Authors: Kumar Khushmeet , Yu Ruiling , Smail Boussaadi , ER Rakesh Kumar , Lal Sujesh P. 
Published: May 2022

Background:
Buildings, in the traditional sense, are becoming increasingly incapable
of meeting modern humans’ pursuit of high-quality living and working environments. With the
increasing pace of urban development, modern buildings are becoming increasingly popular.

Objective:
We investigate an electronic data energy consumption monitoring system based on the
construction of Internet of Things for the airport building.

Aim:
A model based on Dynamic Programming Genetic Algorithm (DPGA) is proposed to generate parameter and service models based on user scenarios.

Methods:
Two definitions are presented for the communication format between the middleware
and the Wireless Sensor Network (WSN); the software and hardware functions of the nodes of the
system's WSN are designed, and part of the node is implemented. Finally, the specific implementation of the application program interface and data interface between the modules of the middleware system are described considering the internal environment of a typical office building as an
example. The deployment plan of system nodes in specific environments and the division of similar areas are discussed

Results:
The platform can strictly monitor and manage energy-consuming equipment.

Conclusion:
The proposed model can be used to achieve reasonable distribution of energy consumption, energy saving, and humanised and automated energy consumption monitoring functions in the office areas of large office buildings in modern cities.
Ethical, Legal, and Social Implications of Symptom Checker Apps in Primary Health Care (CHECK.APP): Protocol for an Interdisciplinary Mixed Methods Study
Authors: Wetzel Anna-Jasmin , Koch Roland , Preiser Christine , Müller Regina , Klemmt Malte , Ranisch Robert , Ehni Hans-Jörg , Wiesing Urban , Rieger Monika A , Henking Tanja , Joos Stefanie 
Published: May 2022

Background
Symptom checker apps (SCAs) are accessible tools that provide early symptom assessment for users. The ethical, legal, and social implications of SCAs and their impact on the patient-physician relationship, the health care providers, and the health care system have sparsely been examined. This study protocol describes an approach to investigate the possible impacts and implications of SCAs on different levels of health care provision. It considers the perspectives of the users, nonusers, general practitioners (GPs), and health care experts.

Objective
We aim to assess a comprehensive overview of the use of SCAs and address problematic issues, if any. The primary outcomes of this study are empirically informed multi-perspective recommendations for different stakeholders on the ethical, legal, and social implications of SCAs.

Methods
Quantitative and qualitative methods will be used in several overlapping and interconnected study phases. In study phase 1, a comprehensive literature review will be conducted to assess the ethical, legal, social, and systemic impacts of SCAs. Study phase 2 comprises a survey that will be analyzed with a logistic regression. It aims to assess the user degree of SCAs in Germany as well as the predictors for SCA usage. Study phase 3 will investigate self-observational diaries and user interviews, which will be analyzed as integrated cases to assess user perspectives, usage pattern, and arising problems. Study phase 4 will comprise GP interviews to assess their experiences, perspectives, self-image, and concepts and will be analyzed with the basic procedure by Kruse. Moreover, interviews with health care experts will be conducted in study phase 3 and will be analyzed by using the reflexive thematical analysis approach of Braun and Clark.

Results
Study phase 1 will be completed in November 2021. We expect the results of study phase 2 in December 2021 and February 2022. In study phase 3, interviews are currently being conducted. The final study endpoint will be in February 2023.

Conclusions
The possible ethical, legal, social, and systemic impacts of a widespread use of SCAs that affect stakeholders and stakeholder groups on different levels of health care will be identified. The proposed methodological approach provides a multifaceted and diverse empirical basis for a broad discussion on these implications.

Trial Registration
German Clinical Trials Register (DRKS) DRKS00022465; https://tinyurl.com/yx53er67

International Registered Report Identifier (IRRID)
DERR1-10.2196/34026
Skin Cancer Narratives on Instagram: Content Analysis
Authors: Gomaa Basma , Houghton Rebecca F , Crocker Nicole , Walsh-Buhi Eric R 
Published: May 2022

Background
Skin cancer is among the deadliest forms of cancer in the United States. The American Cancer Society reported that 3 million skin cancer cases could be avoided every year if individuals are more aware of the risk factors related to sun exposure and prevention. Social media platforms may serve as potential intervention modalities that can be used to raise public awareness of several diseases and health conditions, including skin cancer. Social media platforms are efficient, cost-effective tools for health-related content that can reach a broad number of individuals who are already using these spaces in their day-to-day personal lives. Instagram was launched in 2010, and it is now used by 1 billion users, of which 90% are under the age of 35 years. Despite previous research highlighting the potential of image-based platforms in skin cancer prevention and leveraging Instagram’s popularity among the priority population to raise awareness, there is still a lack of studies describing skin cancer–related content on Instagram.

Objective
This study aims to describe skin cancer–related content on Instagram, including the type of account; the characteristics of the content, such as the kind of media used; and the type of skin cancer discussed. This study also seeks to reveal content themes in terms of skin cancer risks, treatment, and prevention.

Methods
Through CrowdTangle, a Facebook-owned tool, we retrieved content from publicly available accounts on Instagram for the 30 days preceding May 14, 2021. Out of 2932 posts, we randomly selected 1000 posts for review. Of the 1000 posts, 592 (59.2%) met the following inclusion criteria: (1) content was focused on human skin cancer, (2) written in English language only, and (3) originated from the United States. Guided by previous research and through an iterative process, 2 undergraduate students independently coded the remaining posts. The 2 coders and a moderator met several times to refine the codebook.

Results
Of the 592 posts, profiles representing organizations (n=321, 54.2%) were slightly more common than individual accounts (n=256, 43.2%). The type of media included in the posts varied, with posts containing photos occurring more frequently (n=315, 53.2%) than posts containing infographics (n=233, 39.4%) or videos (n=85, 14.4%). Melanoma was the most mentioned type of skin cancer (n=252, 42.6%). Prevention methods (n=404, 68.2%) were discussed in Instagram posts more often than risk factors (n=271, 45.8%). Only 81 out of 592 (13.7%) posts provided a citation.

Conclusions
This study’s findings highlight the potential role of Instagram as a platform for improving awareness of skin cancer risks and the benefits of prevention practices. We believe that social media is the most promising venue for researchers and dermatologists to dedicate their efforts and presence that can widely reach the public to educate about skin cancer and empower prevention.
Attitudes of Patients With Chronic Heart Failure Toward Digital Device Data for Self-documentation and Research in Germany: Cross-sectional Survey Study
Authors: Buhr Lorina , Kaufmann Pauline Lucie Martiana , Jörß Katharina 
Published: May 2022

Background
In recent years, the use of digital mobile measurement devices (DMMDs) for self-documentation in cardiovascular care in Western industrialized health care systems has increased. For patients with chronic heart failure (cHF), digital self-documentation plays an increasingly important role in self-management. Data from DMMDs can also be integrated into telemonitoring programs or data-intensive medical research to collect and evaluate patient-reported outcome measures through data sharing. However, the implementation of data-intensive devices and data sharing poses several challenges for doctors and patients as well as for the ethical governance of data-driven medical research.

Objective
This study aims to explore the potential and challenges of digital device data in cardiology research from patients’ perspectives. Leading research questions of the study concerned the attitudes of patients with cHF toward health-related data collected in the use of digital devices for self-documentation as well as sharing these data and consenting to data sharing for research purposes.

Methods
A cross-sectional survey of patients of a research in cardiology was conducted at a German university medical center (N=159) in 2020 (March to July). Eligible participants were German-speaking adult patients with cHF at that center. A pen-and-pencil questionnaire was sent by mail.

Results
Most participants (77/105, 73.3%) approved digital documentation, as they expected the device data to help them observe their body and its functions more objectively. Digital device data were believed to provide cognitive support, both for patients’ self-assessment and doctors’ evaluation of their patients’ current health condition. Interestingly, positive attitudes toward DMMD data providing cognitive support were, in particular, voiced by older patients aged >65 years. However, approximately half of the participants (56/105, 53.3%) also reported difficulty in dealing with self-documented data that lay outside the optimal medical target range. Furthermore, our findings revealed preferences for the self-management of DMMD data disclosed for data-intensive medical research among German patients with cHF, which are best implemented with a dynamic consent model.

Conclusions
Our findings provide potentially valuable insights for introducing DMMD in cardiovascular research in the German context. They have several practical implications, such as a high divergence in attitudes among patients with cHF toward different data-receiving organizations as well as a large variance in preferences for the modes of receiving information included in the consenting procedure for data sharing for research. We suggest addressing patients’ multiple views on consenting and data sharing in institutional normative governance frameworks for data-intensive medical research.
Diagnóstico de la calidad sanitaria de queserías artesanales en Salinas, San Luis Potosí
Authors: Rodríguez-Gallegos Rocío , Álvarez-Fuentes Gregorio , Rendón-Huerta Juan Antonio , Morales-Rueda Juan Ángel , García-López Juan Carlos , Olvera-Vargas Luis Alberto 
Published: May 2022

El objetivo de este trabajo fue evaluar la carga microbiológica de coliformes totales (CT), Staphylococcus aureus y Salmonella spp en leche y quesos frescos como indicadores de prácticas de proceso que se realizan en queserías de diferentes localidades de la región de Salinas, San Luis Potosí. Se muestrearon 15 establecimientos, se obtuvieron muestras de leche y queso y se les realizó un análisis de composición de la leche y microbiológico. El 65 % de las unidades de producción no pasteuriza la leche o utiliza cuajo natural. Los conteos más elevados en leche fueron de 42 x 109 y 40 x 109 UFC/ml para S. aureus y CT, respectivamente. Para queso, las cuentas de 32 x 109 y 26 x 109 UFC/g para S. aureus y CT, respectivamente. Además, se detectó presencia de Salmonella en leche y queso. Se concluye que la falta de higiene en los utensilios y equipos en los que se elaboran los quesos, así como el uso de cuajo natural, pueden ser un riesgo para la salud del consumidor.
Rethinking Suspicion: A Canonical-Agrarian Reading of Isaiah 65
Authors: Stulac Daniel J. 
Published: May 2022

ABSTRACT
This essay addresses Isa 65 from a canonical-agrarian perspective, that is, with an eye for both the chapter's literary situation within the greater biblical book and its potential value for ecologically concerned "eaters" in the present day. Through language dealing with food production and consumption, chap. 65 extends a typology of hunger and satiety found earlier in the book in terms that are interdependently theological, ecological, and anthropological. This essay treats these three characteristics as irreducibly complex, an approach that differs from the ecological hermeneutic characteristic of the Earth Bible project, which seeks to isolate, identify with, and retrieve the text's ecological importance over against its anthropocentrism. This sort of approach tends to produce few text-based conclusions that better inform human behavior with respect to planet earth, precisely because human interests are prejudicially excised from the text's interpretation. By contrast, this essay concludes with three such practical proposals, each of which is tethered to a different aspect of the chapter's complex interest in food. The contemporary reader who would maintain a biblical hermeneutic of trust while also seeking to address humanity's growing ecological challenges may find this essay a valuable resource.
Interpretation, Not Repetition: Reflections on Bultmann as a Theological Reader of Paul
Authors: Barclay John M. G. 
Published: May 2022

ABSTRACT
Bultmann's Theology of the New Testament is instructive as a theological performance, which goes beyond redescription to theological explication. His reading of Paul illustrates his approach to theological interpretation, which is integral to the responsibility of theology to each new generation. Although we should now do theology with the NT in a very different form, Bultmann's challenge remains: to go beyond mere repetition in order to render this text theologically fruitful, and communicable as good news, in our contemporary context.