bluuebunny/crossref_metadata_2025_split huggingface dataset:
Euclidean affine functions and their application to calendar algorithms
Authors: Neri Cassio , Schneider Lorenz 
Published: December 2022

AbstractIn everyday life, dates are specified in terms of year, month and day, but this is not how digital devices represent them. Such devices continuously count elapsed days since a certain reference date, usually 1 January 1970. Accordingly, the date exactly one year after this reference is 1 January 1971 and digital devices represent it as 365. Conversions between machine and human formats are, arguably, amongst the most common operations performed by digital devices and constitute the subject of this article. We introduce Euclidean affine functions (EAFs) and study their properties. EAFs are of the form , where , , , and are integers and where denotes the quotient of Euclidean division. We derive algebraic relations and numerical approximations that are important for the efficient evaluation of these expressions in modern CPUs. Since division is a particular case of an EAF (when and ), the optimisations proposed in this article can also be applied to division. The main application presented in this article is the derivation of conversion algorithms for the Gregorian calendar. We will show that they can be implemented substantially more efficiently than is currently the case in widely used C, C++, C#, and Java open source libraries. Gains in speed of a factor of two or more are common. These algorithms have been implemented in GCC, the Linux Kernel and .NET.
A comparative cradle‐to‐gate life cycle assessment of carbon fiber‐reinforced polymer and steel‐reinforced bridges
Authors: Khorgade Prathamesh , Rettinger Martin , Burghartz Anne , Schlaich Mike 
Published: December 2022

AbstractCarbon fiber‐reinforced polymer (CFRP) has proven to be an excellent replacement for conventionally used steel in the construction industry. This is especially relevant in bridge engineering, where its corrosion resistance, low weight‐to‐strength ratio, and outstanding fatigue properties can be put to appropriate use, for example, to prestress the bridge girders. These properties are a huge part of the success of prestressed CFRP bridges, which tremendously increase the structural and material efficiency and hence help facilitate the construction of slender and durable bridges. However, apart from the structural performance of the bridges, the aspect of sustainability (environmental viability, economic feasibility, and social acceptance) plays a vital role in determining the overall efficiency. Prior studies have illustrated that the CFRP reinforcements in themselves are relatively unsustainable as compared to conventional steel reinforcements. However, owing to the extraordinarily high material efficiency generally associated with structures built with CFRP reinforcements, it can be hypothesized that these are equally or even more sustainable as compared to their counterparts. In this study, an aspect of sustainability, namely, environmental impact, is addressed. As a first part of the study, cradle‐to‐gate CO2 emissions for conventional building materials and CFRP have been thoroughly reviewed and documented. Attributed to the heterogeneity of the data available for CO2 emissions from CFRP reinforcements, three scenarios (favorable, realistic, and unfavorable) were drawn up. Based on these values, a comparative life cycle assessment was undertaken for two bridge systems, namely, Rosensteinsteg II (already constructed) and an overpass over German highway A‐20 (design in process). For each bridge system, two separate variants with steel and CFRP reinforcements were considered. For Rosensteinsteg II, a reduction of approximately 28% was observed in the CO2 emissions (favorable global warming potential values for CFRP) once the steel was replaced with prestressed CFRP. A total of 18% reduction was observed for the A‐20 bridge with CFRP reinforcements. With the help of the current study, it could be concluded that, especially for bridges not experiencing heavy vehicular loads, prestressed CFRP bridges are the most environmentally feasible option.
Enhancement of the punching shear verification of slabs with openings
Authors: dos Santos Júlia Borges , Muttoni Aurelio , de Melo Guilherme Sales 
Published: December 2022

AbstractOpenings in flat slabs near to columns are often needed to supply the building with utilities. The presence of these openings can lead to a decrease of the punching resistance which is related to (i) the reduction of the control perimeter, (ii) the stress concentrations at the edges of the openings, (iii) the reduction of the unitary shear resistance caused by increased flexural deformations, and (iv) the moment transfer in the slab connection in case of unsymmetrical openings. The effect of the openings on the punching shear resistance is strongly related to the geometry, the location, the number, and the size of the openings. To quantify the strength reduction due to the openings, current code approaches account for a reduction of the control perimeter defined by radial lines from the centroid of the column to the edges of the opening. Even though slabs with opening have been investigated since the 1960s, available experimental evidence on the behavior of slabs with openings without shear reinforcement is scarce and some effects are neglected in current design codes. Eurocode 2 and fib Model Code do not consider the effect of unsymmetrical openings leading to moment transfer in the slab‐column connection. ACI 318:2019 recommends considering these cases as free edges; however, additional information is necessary to perform the analysis. The present paper analyses a database of 68 flat slab specimens with openings according to ACI 318:2019, current Eurocode 2 (EN 1992‐1‐1:2004), the draft for the second generation (prEN 1992‐1‐1:2021), fib MC 2010:2013, and the Critical Shear Crack Theory. This paper proposes a new approach and a new definition of the control perimeter to improve the prediction of the punching shear resistance of slabs with openings based on the results of the database, the previous studies, and the linear‐elastic analyses of the shear force distribution along the control perimeter.
Yokukansankachimpihange therapy fortified with bisoprolol and lifestyle changes in a patient intolerant to antihypertensive agents
Authors: Katayose Dai 
Published: December 2022

AbstractCaseModern medicine's technological advancements recognize the contributions of traditional and complementary medicine. Combining Kampo medicine, antihypertensive agents, and lifestyle changes can be an effective, holistic treatment approach for patients with hypertension, frequently accompanied by impaired mental health and quality of life. This case concerns a patient with hypertension who demonstrated poor lifestyle habits, mental stress, and intolerance to antihypertensive agents. The patient was treated with yokukansankachimpihange therapy fortified with bisoprolol and lifestyle changes including dietary modifications, sleep hygiene, and exercise (including street dance).OutcomeThe patient's ambulatory systolic blood pressure decreased from 174.6 ± 16.2 (mean ± SD) to 134 ± 10.4 mm Hg after initiating the fortified yokukansankachimpihange therapy. The patient also experienced improvements in heart palpitations, shortness of breath, anxiety, constipation, and headache severity.ConclusionFortified therapy is an efficacious, advanced integrated medicine approach that can be used to treat patients with hypertension.
The Arabidopsis DUF239 gene family encodes Neprosin‐like proteins that are widely expressed in seed endosperm
Authors: Vergès Valentin , Bellenger Léo , Pichon Olivier , Giglioli‐Guivarc'h Nathalie , Dutilleul Christelle , Ducos Eric 
Published: December 2022

AbstractDomain of unknown function 239 (DUF239) is a conserved sequence found in the catalytic site of Neprosins which are specific secreted prolyl endopeptidases found in the Nepenthes genus. Neprosins participate in the nitrogen cycle by digesting preys trapped in the pitcher of these carnivorous plants. Apart from that, DUF239s have been poorly documented in plants. We have identified 50 genes containing DUF239‐coding sequences in the Arabidopsis genome that are distributed across six distinct phylogenetic clusters. The chromosomal distribution suggests that several genes are the result of recent duplication events, with up to eight genes found in a strict tandem distribution. In Arabidopsis, most of DUF239‐containing sequences are also associated to a Neprosin‐activating domain (DUF4409) and an amino‐terminal α‐helix which corresponds to the typical domain organization of the Neprosins described in the Nepenthes genus. Analysis of Arabidopsis transcriptomic datasets reveals that 39 genes are exclusively expressed in reproductive organs, mainly during seed development and more specifically in the endosperm (23 genes). The peculiar expression pattern of the DUF239 gene family in Arabidopsis suggests new functions of Neprosin‐like proteins in plants during seed development.
Gastric cancer detection by non‐blood‐based liquid biopsies: A systematic review looking into the last decade of research
Authors: Lopes Catarina , Chaves Jéssica , Ortigão Raquel , Dinis‐Ribeiro Mário , Pereira Carina 
Published: December 2022

AbstractGastric cancer (GC) screening is arguable in most Western countries. Liquid biopsies are a great promise to answer the unmet need for less invasive diagnostic biomarkers in GC. Thus, we aimed at systematically reviewing the current knowledge on liquid biopsy‐based biomarkers in GC screening. A systematic search on PubMed/MEDLINE and Scopus databases was performed on published articles reporting the use of non‐blood specimen (saliva, gastric juice [GJ], urine and stool) on GC diagnosis. 3208 records were retrieved by June 2022. After removal of duplicate records, 2379 abstracts were screened, and 84 full texts included in this systematic review. More than 90% of studies were reported on Asian populations. Overall, 9 studies explored stool‐, 12 saliva‐, and 29 urine‐derived biomarkers for GC detection. Additionally, 37 studies, representing the majority, analyzed GJ, focusing on nucleic acid molecules. Several miRNAs and lncRNA molecules have been associated with GC risk, particularly miR‐21 (area under the curve [AUC] = 0.97, 95% CI: 0.94–1.00). Considering salivary biomarkers, the best described model in validation sets included the soybean agglutinin and Vicia villosa agglutinin lectins (AUC = 0.89, 95% CI: 0.80–0.99). Most studies in urine carried out metabolomic approaches, with two discriminatory models presenting AUC values superior to 0.97. This systematic review emphasizes the potential role of non‐blood‐based biomarkers, although further validation, particularly in Western countries, is mandatory, namely for non‐invasive screening and/or monitoring, as well as the use of GJ as a tool to enhance upper gastrointestinal endoscopy accuracy.
Holographic Lorentz and Carroll frames
Authors: Campoleoni Andrea , Ciambelli Luca , Delfante Arnaud , Marteau Charles , Petropoulos P. Marios , Ruzziconi Romain 
Published: December 2022

Abstract
Relaxing the Bondi gauge, the solution space of three-dimensional gravity in the metric formulation has been shown to contain an additional free function that promotes the boundary metric to a Lorentz or Carroll frame, in asymptotically AdS or flat spacetimes. We pursue this analysis and show that the solution space also admits a finite symplectic structure, obtained taking advantage of the built-in ambiguities. The smoothness of the flat limit of the AdS symplectic structure selects a prescription in which the holographic anomaly appears in the boundary Lorentz symmetry, that rotates the frame. This anomaly turns out to be cohomologically equivalent to the standard holographic Weyl anomaly and survives in the flat limit, thus predicting the existence of quantum anomalies in conformal Carrollian field theories. We also revisit these results in the Chern-Simons formulation, where the prescription for the symplectic structure admitting a smooth flat limit follows from the variational principle, and we compute the charge algebra in the boundary conformal gauge.
Bounds on right-handed neutrino parameters from observable leptogenesis
Authors: Hernández P. , López-Pavón J. , Rius N. , Sandner S. 
Published: December 2022

Abstract
We revisit the generation of a matter-antimatter asymmetry in the minimal extension of the Standard Model with two singlet heavy neutral leptons (HNL) that can explain neutrino masses. We derive an accurate analytical approximation to the solution of the complete linearized set of kinetic equations, which exposes the non-trivial parameter dependencies in the form of parameterization-independent CP invariants. The identification of various washout regimes relevant in different regions of parameter space sheds light on the relevance of the mass corrections in the interaction rates and clarifies the correlations of baryogenesis with other observables. In particular, by requiring that the measured baryon asymmetry is reproduced, we derive robust upper or lower bounds on the HNL mixings depending on their masses, and constraints on their flavour structure, as well as on the CP-violating phases of the PMNS mixing matrix, and the amplitude of neutrinoless double-beta decay. We also find certain correlations between low and high scale CP phases. Especially emphasizing the testable part of the parameter space we demonstrate that our findings are in very good agreement with numerical results. The methods developed in this work can help in exploring more complex scenarios.
Automated consistent truncations and stability of flux compactifications
Authors: Andriot David , Marconnet Paul , Rajaguru Muthusamy , Wrase Timm 
Published: December 2022

Abstract
Classical flux compactifications contribute to a well-controlled corner of the string landscape, therefore providing an important testing ground for a variety of conjectures. We focus here on type II supergravity compactifications on 6d group manifolds towards 4d maximally symmetric spacetimes. We develop a code where the truncation to left-invariant scalars and the dimensional reduction to a 4d theory are automated, for any possible configuration of Op-planes and Dp-branes. We then prove that any such truncation is consistent. We further compute the mass spectrum and analyse the stability of many de Sitter, Minkowski or anti-de Sitter solutions, as well as their consistency with swampland conjectures.
Lower and Upper Estimates of the Quantity of Algebraic Numbers
Authors: Sergeyev Yaroslav D. 
Published: December 2022

AbstractIt is well known that the set of algebraic numbers (let us call it A) is countable. In this paper, instead of the usage of the classical terminology of cardinals proposed by Cantor, a recently introduced methodology using $$\textcircled {1}$$

1

-based infinite numbers is applied to measure the set A (where the number $$\textcircled {1}$$

1

is called grossone). Our interest to this methodology is explained by the fact that in certain cases where cardinals allow one to say only whether a set is countable or it has the cardinality of the continuum, the $$\textcircled {1}$$

1

-based methodology can provide a more accurate measurement of infinite sets. In this article, lower and upper estimates of the number of elements of A are obtained. Both estimates are expressed in $$\textcircled {1}$$

1

-based numbers.
The Frobenius Problem for Generalized Repunit Numerical Semigroups
Authors: Branco Manuel B. , Colaço Isabel , Ojeda Ignacio 
Published: December 2022

AbstractIn this paper, we introduce and study the numerical semigroups generated by $$\{a_1, a_2, \ldots \} \subset {\mathbb {N}}$$

{

a
1

,

a
2

,
…
}
⊂
N

such that $$a_1$$

a
1

is the repunit number in base $$b > 1$$

b
>
1

of length $$n > 1$$

n
>
1

and $$a_i - a_{i-1} = a\, b^{i-2},$$

a
i

-

a

i
-
1

=
a

b

i
-
2

,

for every $$i \ge 2$$

i
≥
2

, where a is a positive integer relatively prime with $$a_1$$

a
1

. These numerical semigroups generalize the repunit numerical semigroups among many others. We show that they have interesting properties such as being homogeneous and Wilf. Moreover, we solve the Frobenius problem for this family, by giving a closed formula for the Frobenius number in terms of a, b and n, and compute other usual invariants such as the Apéry sets, the genus or the type.
The endocytic recycling compartment serves as a viral factory for hepatitis E virus
Authors: Bentaleb Cyrine , Hervouet Kévin , Montpellier Claire , Camuzet Charline , Ferrié Martin , Burlaud-Gaillard Julien , Bressanelli Stéphane , Metzger Karoline , Werkmeister Elisabeth , Ankavay Maliki , Janampa Nancy Leon , Marlet Julien , Roux Julien , Deffaud Clarence , Goffard Anne , Rouillé Yves , Dubuisson Jean , Roingeard Philippe , Aliouat-Denis Cécile-Marie , Cocquerel Laurence 
Published: December 2022

AbstractAlthough hepatitis E virus (HEV) is the major leading cause of enterically transmitted viral hepatitis worldwide, many gaps remain in the understanding of the HEV lifecycle. Notably, viral factories induced by HEV have not been documented yet, and it is currently unknown whether HEV infection leads to cellular membrane modeling as many positive-strand RNA viruses. HEV genome encodes the ORF1 replicase, the ORF2 capsid protein and the ORF3 protein involved in virion egress. Previously, we demonstrated that HEV produces different ORF2 isoforms including the virion-associated ORF2i form. Here, we generated monoclonal antibodies that specifically recognize the ORF2i form and antibodies that recognize the different ORF2 isoforms. One antibody, named P1H1 and targeting the ORF2i N-terminus, recognized delipidated HEV particles from cell culture and patient sera. Importantly, AlphaFold2 modeling demonstrated that the P1H1 epitope is exposed on HEV particles. Next, antibodies were used to probe viral factories in HEV-producing/infected cells. By confocal microscopy, we identified subcellular nugget-like structures enriched in ORF1, ORF2 and ORF3 proteins and viral RNA. Electron microscopy analyses revealed an unprecedented HEV-induced membrane network containing tubular and vesicular structures. We showed that these structures are dependent on ORF2i capsid protein assembly and ORF3 expression. An extensive colocalization study of viral proteins with subcellular markers, and silencing experiments demonstrated that these structures are derived from the endocytic recycling compartment (ERC) for which Rab11 is a central player. Hence, HEV hijacks the ERC and forms a membrane network of vesicular and tubular structures that might be the hallmark of HEV infection.
Zinc on the edge—isotopic and geophysical evidence that cratonic edges control world-class shale-hosted zinc-lead deposits
Authors: Huston David L. , Champion David C. , Czarnota Karol , Duan Jingming , Hutchens Matthew , Paradis Suzanne , Hoggard Mark , Ware Bryant , Gibson George M. , Doublier Michael P. , Kelley Karen , McCafferty Anne , Hayward Nathan , Richards Fred , Tessalina Svetlana , Carr Graham 
Published: December 2022

Abstract
The North Australian Zinc Belt is the largest zinc-lead province in the world, containing three of the ten largest known individual deposits (HYC, Hilton-George Fisher, and Mount Isa). The Northern Cordillera in North America is the second largest zinc-lead province, containing a further two of the world’s top ten deposits (Red Dog and Howards Pass). Despite this world-class endowment, exploration in both mineral provinces during the past 2 decades has not been particularly successful, yielding only two significant discoveries (Teena, Australia, and Boundary, Canada). One of the most important aspects of exploration is to choose mineral provinces and districts within geological belts that have the greatest potential for discovery. Here, we present results from these two zinc belts that highlight previously unused datasets for area selection and targeting. Lead isotope mapping using analyses of mineralized material has identified gradients in μ (238U/204Pb) that coincide closely with many major deposits. Locations of these deposits also coincide with a gradient in the depth of the lithosphere-asthenosphere boundary determined from calibrated surface wave tomography models converted to temperature. Furthermore, gradients in upward-continued gravity anomalies and a step in Moho depth correspond to a pre-existing major crustal boundary in both zinc belts. A spatial association of deposits with a linear mid- to lower-crustal resistivity anomaly from magnetotelluric data is also observed in the North Australian Zinc Belt. The change from thicker to thinner lithosphere is interpreted to localize prospective basins for zinc-lead mineralization and to control the gradient in lead isotope and geophysical data. These data, when combined with data indicative of paleoenvironment and changes in plate motion at the time of mineralization, provide new exploration criteria that can be used to identify prospective mineralized basins and define the most favorable parts of these basins.
Income windfalls and overweight: evidence from lottery wins
Authors: Costa-Font Joan , Györi Mario 
Published: December 2022

AbstractWe examine the impact of an income windfall (from a lottery win) on an individual's overweight and Body Mass Index (BMI). We use longitudinal data from the United Kingdom, where a large proportion of the population plays the lottery, and retrieve income effect estimates using time and individual specific fixed effects alongside a set of relevant controls. Although our findings suggest any income windfall may lead to a contemporaneous increase in overweight, we document evidence that a £1,000 win reduces the probability of overweight in the range by up to 3 percentual points 12 months after the lottery win. Estimates are heterogeneous across working hours and educational attainment. A £1000 lottery win reduces the risk of overweight among low educated individuals by 4.5–5 percentual points (pp)12 months after the lottery win.
Ground state representations of topological groups
Authors: Neeb Karl-Hermann , Russo Francesco G. 
Published: December 2022

AbstractLet $$\alpha : {{\mathbb {R}}}\rightarrow \mathop {\textrm{Aut}}\nolimits (G)$$

α
:
R
→
Aut
(
G
)

define a continuous $${{\mathbb {R}}}$$
R
-action on the topological group G. A unitary representation $$(\pi ^\flat ,\mathcal {H})$$

(

π
♭

,
H
)

of the extended group $$G^\flat := G \rtimes _\alpha {{\mathbb {R}}}$$

G
♭

:
=
G

⋊
α

R

is called a ground state representation if the unitary one-parameter group $$\pi ^\flat (e,t) = e^{itH}$$

π
♭

(
e
,
t
)

=

e

itH

has a non-negative generator $$H \ge 0$$

H
≥
0

and the subspace $$\mathcal {H}^0 := \ker H$$

H

0

:
=
ker
H

of ground states generates $$\mathcal {H}$$
H
under G. In this paper, we introduce the class of strict ground state representations, where $$(\pi ^\flat ,\mathcal {H})$$

(

π
♭

,
H
)

and the representation of the subgroup $$G^0 := \mathop {\textrm{Fix}}\nolimits (\alpha )$$

G
0

:
=
Fix

(
α
)

on $$\mathcal {H}^0$$

H

0

have the same commutant. The advantage of this concept is that it permits us to classify strict ground state representations in terms of the corresponding representations of $$G^0$$

G
0

. This is particularly effective if the occurring representations of $$G^0$$

G
0

can be characterized intrinsically in terms of concrete positivity conditions. To find such conditions, it is natural to restrict to infinite dimensional Lie groups such as (1) Heisenberg groups (which exhibit examples of non-strict ground state representations); (2) Finite dimensional groups, where highest weight representations provide natural examples; (3) Compact groups, for which our approach provides a new perspective on the classification of unitary representations; (4) Direct limits of compact groups, as a class of examples for which strict ground state representations can be used to classify large classes of unitary representations.