bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategy to minimize bending strain interference for flexible acoustic wave sensing platform
Authors: Zhou Jian , Ji Zhangbin , Guo Yihao , Liu Yanghui , Zhuo Fengling , Zheng Yuanjin , Gu Yuandong , Fu YongQing , Duan Huigao 
Published: September 2022

AbstractThere are great concerns for sensing using flexible acoustic wave sensors and lab-on-a-chip, as mechanical strains will dramatically change the sensing signals (e.g., frequency) when they are bent during measurements. These strain-induced signal changes cannot be easily separated from those of real sensing signals (e.g., humidity, ultraviolet, or gas/biological molecules). Herein, we proposed a new strategy to minimize/eliminate the effects of mechanical bending strains by optimizing off-axis angles between the direction of bending deformation and propagation of acoustic waves on curved surfaces of layered piezoelectric film/flexible glass structure. This strategy has theoretically been proved by optimization of bending designs of off-axis angles and acoustically elastic effect. Proof-of-concept for humidity and ultraviolet-light sensing using flexible SAW devices with negligible interferences are achieved within a wide range of bending strains. This work provides the best solution for achieving high-performance flexible acoustic wave sensors under deformed/bending conditions.
Fundamental limits of quantum error mitigation
Authors: Takagi Ryuji , Endo Suguru , Minagawa Shintaro , Gu Mile 
Published: September 2022

AbstractThe inevitable accumulation of errors in near-future quantum devices represents a key obstacle in delivering practical quantum advantages, motivating the development of various quantum error-mitigation methods. Here, we derive fundamental bounds concerning how error-mitigation algorithms can reduce the computation error as a function of their sampling overhead. Our bounds place universal performance limits on a general error-mitigation protocol class. We use them to show (1) that the sampling overhead that ensures a certain computational accuracy for mitigating local depolarizing noise in layered circuits scales exponentially with the circuit depth for general error-mitigation protocols and (2) the optimality of probabilistic error cancellation among a wide class of strategies in mitigating the local dephasing noise on an arbitrary number of qubits. Our results provide a means to identify when a given quantum error-mitigation strategy is optimal and when there is potential room for improvement.
Audiovisual temporal processing in adult patients with first-episode schizophrenia and high-functioning autism
Authors: Zhou Han-yu , Lai Iris Y. S. , Hung Karen S. Y. , Chan Mandy K. M. , Ho Zoe T. Y. , Lam Jenny P. H. , Lui Simon S. Y. , Chan Raymond C. K. 
Published: September 2022

AbstractSchizophrenia and autism spectrum disorder (ASD) are both neurodevelopmental disorders with altered sensory processing. Widened temporal binding window (TBW) signifies reduced sensitivity to detect stimulus asynchrony, and may be a shared feature in schizophrenia and ASD. Few studies directly compared audiovisual temporal processing ability in the two disorders. We recruited 43 adult patients with first-episode schizophrenia (FES), 35 average intelligent and verbally-fluent adult patients with high-functioning ASD and 48 controls. We employed two unisensory Temporal Order Judgement (TOJ) tasks within visual or auditory modalities, and two audiovisual Simultaneity Judgement (SJ) tasks with flash-beeps and videos of syllable utterance as stimuli. Participants with FES exhibited widened TBW affecting both speech and non-speech processing, which were not attributable to altered unisensory sensory acuity because they had normal visual and auditory TOJ thresholds. However, adults with ASD exhibited intact unisensory and audiovisual temporal processing. Lower non-verbal IQ was correlated with larger TBW width across the three groups. Taking our findings with earlier evidence in chronic samples, widened TBW is associated with schizophrenia regardless illness stage. The altered audiovisual temporal processing in ASD may ameliorate after reaching adulthood.
Strategy to improve Cu-BTC metal-organic frameworks performance in removal of Rhodamine B: MD and WT-MtD simulations assessment
Authors: Razavi Leila , Raissi Heidar , Hashemzadeh Hassan , Farzad Farzaneh 
Published: September 2022

AbstractWith industry progress, environmental problems have begun to threaten human health. Among them, water pollution is closely related to human life and has attracted researchers’ attention. Hence, coping strategies for these pollutants have become a priority nowadays. Here, we carried out the molecular dynamics (MD) and well-tempered metadynamics simulations to evaluate the interaction of Rhodamine B (Rh B) with a copper (II)-benzene-1,3,5-tricarboxylate metal-organic framework (Cu-BTC/MOF). To design a more efficient dye removal platform, the effect of the -NH2, -OH, and -NO2 functional groups on the efficiency of Cu-BTC/MOF in the adsorption of Rh B is investigated. It is found that the interaction energy of Rh B with -NH2-MOF, -OH-MOF, and -NO2-MOF is about −79.98, −121.87, and −365.55 kJ mol−1, respectively, more than the pristine case. This observation confirms that the functionalization strategy can enhance the Cu-BTC/MOF efficiency. The obtained free energy (FE) values from the metadynamics simulation indicated that for adsorption of Rh B on pristine, -NH2-MOF, -OH-MOF, and -NO2-MOF, the global minimums are located about at −220.47, −234.75, −236.09, and −259.01 kJ mol−1, respectively. The obtained results show that in the two-dimensional FE surfaces, the most stable complex with Rh B belongs to the MOF-NO2 system.
Osteogenesis in human periodontal ligament stem cell sheets is enhanced by the protease-activated receptor 1 (PAR1) in vivo
Authors: Alves Tomaz , Gasparoni Letícia M. , Balzarini Danilo , Albuquerque-Souza Emmanuel , de Oliveira Victhor , Rovai Emanuel S. , da Silva Jose , Huamán-Mendoza Aldrin , Catalani Luiz H. , Sipert Carla R. , Holzhausen Marinella 
Published: September 2022

AbstractHuman periodontal ligament stem cells (PDLSCs) have been studied as a promising strategy in regenerative approaches. The protease-activated receptor 1 (PAR1) plays a key role in osteogenesis and has been shown to induce osteogenesis and increase bone formation in PDLSCs. However, little is known about its effects when activated in PDLSCs as a cell sheet construct and how it would impact bone formation as a graft in vivo. Here, PDLSCs were obtained from 3 patients. Groups were divided into control, osteogenic medium and osteogenic medium + PAR1 activation by TFLLR-NH2 peptide. Cell phenotype was determined by flow cytometry and immunofluorescence. Calcium deposition was quantified by Alizarin Red Staining. Cell sheet microstructure was analyzed through light, scanning electron microscopy and histology and transplanted to Balb/c nude mice. Immunohistochemistry for bone sialoprotein (BSP), integrin β1 and collagen type 1 and histological stains (H&E, Van Giesson, Masson’s Trichrome and Von Kossa) were performed on the ex-vivo mineralized tissue after 60 days of implantation in vivo. Ectopic bone formation was evaluated through micro-CT. PAR1 activation increased calcium deposition in vitro as well as BSP, collagen type 1 and integrin β1 protein expression and higher ectopic bone formation (micro-CT) in vivo.
Differentiating central nervous system infection from disease infiltration in hematological malignancy
Authors: Lim Emma A. , Ruffle James K. , Gnanadurai Roshina , Lee Heather , Escobedo-Cousin Michelle , Wall Emma , Cwynarski Kate , Heyderman Robert S. , Miller Robert F. , Hyare Harpreet 
Published: September 2022

AbstractHematological malignancies place individuals at risk of CNS involvement from their hematological disease and opportunistic intracranial infection secondary to disease-/treatment-associated immunosuppression. Differentiating CNS infection from hematological disease infiltration in these patients is valuable but often challenging. We sought to determine if statistical models might aid discrimination between these processes. Neuroradiology, clinical and laboratory data for patients with hematological malignancy at our institution between 2007 and 2017 were retrieved. MRI were deep-phenotyped across anatomical distribution, presence of pathological enhancement, diffusion restriction and hemorrhage and statistically modelled with Bayesian-directed probability networks and multivariate logistic regression. 109 patients were studied. Irrespective of a diagnosis of CNS infection or hematological disease, the commonest anatomical distributions of abnormality were multifocal-parenchymal (34.9%), focal-parenchymal (29.4%) and leptomeningeal (11.9%). Pathological enhancement was the most frequently observed abnormality (46.8%), followed by hemorrhage (22.9%) and restricted diffusion (19.3%). Logistic regression could differentiate CNS infection from hematological disease infiltration with an AUC of 0.85 where, with OR > 1 favoring CNS infection and < 1 favoring CNS hematological disease, significantly predictive imaging features were hemorrhage (OR 24.61, p = 0.02), pathological enhancement (OR 0.17, p = 0.04) and an extra-axial location (OR 0.06, p = 0.05). In conclusion, CNS infection and hematological disease are heterogeneous entities with overlapping radiological appearances but a multivariate interaction of MR imaging features may assist in distinguishing them.
Seasonal temperature variability observed at abyssal depths in the Arabian Sea
Authors: Martin M. V. , Venkatesan R. , Weller Robert A. , Tandon Amit , Joseph K. Jossia 
Published: September 2022

AbstractThe abyssal ocean is generally considered an aseasonal environment decoupled from the variabilities observed at and just below the ocean's surface. Herein, we describe the first in-situ timeseries record of seasonal warming and cooling in the Arabian Sea at a depth of 4000 m. The seasonal cycle was observed over the nearly four-year-long record (from November 2018 to March 2022). The abyssal seasonal temperature cycle also exhibited noticeable interannual variability. We investigate whether or not surface processes influence the near-seabed temperature through deep meridional overturning circulation modulated by the Indian monsoon or by Rossby wave propagation. We also consider if bottom water circulation variability and discharge of the dense Persian Gulf and Red Sea Water may contribute to the observed seasonality.
Entomopathogenic fungi Beauveria bassiana and Metarhizium anisopliae play roles of maize (Zea mays) growth promoter
Authors: Liu Yinmei , Yang Youkun , Wang Bin 
Published: September 2022

AbstractBeauveria bassiana and Metarhizium anisopliae are two of the most important and widely used entomopathogenic fungi (EPFs) to control insect pests. Recent studies have revealed their function in promoting plant growth after artificial inoculation. To better assess fungal colonization and growth-promoting effects of B. bassiana and M. anisopliae on crops, maize Zea mays seedlings were treated separately with 13 B. bassiana and 73 M. anisopliae as rhizosphere fungi in a hydroponic cultural system. Plant growth indexes, including plant height, root length, fresh weight, etc., were traced recorded for 35 days to prove the growth promoting efficiency of the EPFs inoculation. Fungal recovery rate (FRR) verified that both B. bassiana and M. anisopliae could endophytically colonize in maize tissues. The recovery rates of B. bassiana in stems and leaves were 100% on the 7th day, but dropped to 11.1% in the stems and 22.2% in the leaves on the 28th day. Meanwhile, B. bassiana was not detected in the roots until the 28th day, reaching a recovery rate of 33.3%. M. anisopliae strains were isolated from the plant roots, stems and leaves throughout the tracing period with high recovery rates. The systematical colonization of B. bassiana and M. anisopliae in different tissues were further corroborated by PCR amplification of fungus-specified DNA band, which showed a higher detection sensitivity of 100% positive reaction. Fungal density comparing to the initial value in the hydroponic solution, dropped to be well below 1% on the 21st day. Thus, the two selected entomopathogenic fungal strains successfully established endophytic colonization rather than rhizospheric colonization in maize, and significantly promoted its growth in a hydroponic cultural system. Entomopathogenic fungi have great application potential in eco-agricultural fields including biopesticides and biofertilizers.
In vitro larval rearing method of eusocial bumblebee Bombus terrestris for toxicity test
Authors: Kato Yuto , Kikuta Shingo , Barribeau Seth M. , Inoue Maki N. 
Published: September 2022

AbstractBumblebees are important pollinators of wild and agricultural plants but recently have been declining due to various stressors, such as pesticides and diseases. Because of the haplo-diploid sex determination system in hymenopterans, experiments using micro-colonies (small sub colonies without a queen) to identify risks to bumblebee health are limited as they are only able to produce males. Therefore, an experimental protocol for rearing bumblebee larvae in vitro is needed to better understand effects on worker larvae. Here, we aimed to establish a rearing method for larvae of Bombus terrestris for use in risk assessment assays. To confirm the validity of our rearing method, we tested two insecticides used for tomato cultivation, chlorfenapyr and dinotefuran. Bombus terrestris larvae fed with a high nutrient quantity and quality diet increased growth per day. All chlorfenapyr-exposed individuals died within 10 days at 2000-fold dilution, an application dose used for tomatoes. There were significant differences in adult emergence rate among almost all chlorfenapyr treatments. On the other hand, sublethal dinotefuran-exposure did not affect rates of pupation and adult emergence, growth, or larval and pupal periods. Although larvae were smaller than in the natural colony, this rearing method for B. terrestris larvae proved to be effective at evaluating realistic sub-colonies to pesticide exposures.
A simplified GIS and google-earth-based approach for lineaments and terrain attributes mapping in a basement complex terrain
Authors: Lawal M. A. , Oshomoji A. O. , Akinlalu A. A. , Omosanya K. O. , Ndukwe O. S. , Adiat K. A. N. , Mosuro G. O. 
Published: September 2022

AbstractIn this study, we use an integrated geologic mapping technique for remote mapping of lineaments and geologic terrain. Our workflow is based on geographic information system tools and consists of stream network delineation, lineaments mapping, terrain roughness index calculation, and interpretation of structural fabrics from google earth aerial photographs. The case study area, the Idanre Hills in southwestern Nigeria, has a protracted history and is characterized by steep-sided outcrops of a granitic batholith and migmatite-gneiss. Lineaments are widespread and dense around the batholith, occurring in areas of high elevation, and slope gradient. Terrain roughness indices are high at the outcrops and lineament sites. Streams in the area exhibit variable flow and partly align with the lineaments. The high roughness indices observed have tectonic connotations and are related to the occurrence of lineaments, strain domains, and high degree of rock weathering. Importantly, our method is effective in remote mapping of lineaments and terrain attributes within the study area and has wider applications in other basement complex terrains.
Pan-cancer molecular tumor board experience with biomarker-driven precision immunotherapy
Authors: Louie Bryan H. , Kato Shumei , Kim Ki Hwan , Lim Hyo Jeong , Okamura Ryosuke , Eskander Ramez N. , Botta Gregory , Patel Hitendra , Lee Suzanna , Lippman Scott M. , Sicklick Jason K. , Kurzrock Razelle 
Published: September 2022

AbstractDespite remarkable responses to immune checkpoint blockade (ICB) in some advanced cancers, most patients do not benefit, perhaps due to the complexity of tumor/immune/genome interactions. We implemented a multidisciplinary Molecular Tumor Board (MTB) that reviewed multi-omic cancer characteristics to develop N-of-One therapies for patients in the pan-cancer, advanced, refractory setting. This study evaluates the experience of 80 patients who were presented to the MTB and received a treatment regimen that included ICB. Overall, 60/80 patients (75%) who received ICB following MTB discussion had a high degree of matching between tumor molecular characteristics, including ICB biomarkers (reflected by a high Matching Score (≥50%)) and therapy administered. Patients with high versus low Matching Score experienced significantly longer median progression-free survival (6.4 vs. 3.0 months; p = 0.011) and median overall survival (15.3 vs. 4.7 months; p = 0.014) and higher clinical benefit rates (stable disease ≥6 months/partial response/complete response) (53% vs. 21%, p = 0.019). Although most patients (52/80 (65%)) received a personalized combination therapy (e.g., targeted, hormonal, chemotherapy, or a second immunotherapy agent), administering >1 drug was not associated with outcome. Only degree of matching and age, but no other variables, including individual biomarkers (e.g., microsatellite status, tumor mutational burden, or PD-L1 status), were independently correlated with outcome. In the pan-cancer setting, the MTB facilitated a precision medicine strategy to match therapeutic regimens that included ICB alone or combined with matched targeted drugs to patients with advanced malignancy, which was associated with improved clinical outcomes.
Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins
Authors: Hinkle Emma R. , Blue R. Eric , Tsai Yi-Hsuan , Combs Matthew , Davi Jacquelyn , Coffey Alisha R. , Boriek Aladin M. , Taylor Joan M. , Parker Joel S. , Giudice Jimena 
Published: September 2022

AbstractAlternative splicing is an RNA processing mechanism involved in skeletal muscle development and pathology. Muscular diseases exhibit splicing alterations and changes in mechanobiology leading us to investigate the interconnection between mechanical forces and RNA processing. We performed deep RNA-sequencing after stretching muscle cells. First, we uncovered transcriptional changes in genes encoding proteins involved in muscle function and transcription. Second, we observed that numerous mechanosensitive genes were part of the MAPK pathway which was activated in response to stretching. Third, we revealed that stretching skeletal muscle cells increased the proportion of alternatively spliced cassette exons and their inclusion. Fourth, we demonstrated that the serine and arginine-rich proteins exhibited stronger transcriptional changes than other RNA-binding proteins and that SRSF4 phosphorylation is mechanosensitive. Identifying SRSF4 as a mechanosensitive RNA-binding protein that might contribute to crosstalk between mechanotransduction, transcription, and splicing could potentially reveal novel insights into muscular diseases, particularly those with unknown etiologies.
Ultrasonic antifouling devices negatively impact Cuvier’s beaked whales near Guadalupe Island, México
Authors: Trickey Jennifer S. , Cárdenas-Hinojosa Gustavo , Rojas-Bracho Lorenzo , Schorr Gregory S. , Rone Brenda K. , Hidalgo-Pla Eva , Rice Ally , Baumann-Pickering Simone 
Published: September 2022

AbstractWidespread use of unregulated acoustic technologies in maritime industries raises concerns about effects on acoustically sensitive marine fauna worldwide. Anthropogenic noise can disrupt behavior and may cause short- to long-term disturbance with possible population-level consequences, particularly for animals with a limited geographic range. Ultrasonic antifouling devices are commercially available, installed globally on a variety of vessel types, and are marketed as an environmentally-friendly method for biofouling control. Here we show that they can be an acoustic disturbance to marine wildlife, as seasonal operation of these hull-mounted systems by tourist vessels in the marine protected area of Guadalupe Island, México resulted in the reduced presence of a potentially resident population of Cuvier’s beaked whales (Ziphius cavirostris). Human activities are rapidly altering soundscapes on local and global scales, and these findings highlight the need to identify key noise sources and assess their impacts on marine life to effectively manage oceanic ecosystems.
Changing weekend effects of air pollutants in Beijing under 2020 COVID-19 lockdown controls
Authors: Wu Lingyun , Xie Junfei , Kang Keyu 
Published: September 2022

AbstractIn 2020, lockdown control measures were implemented to prevent a novel coronavirus disease 19 (COVID-19) pandemic in many places of the world, which largely reduced human activities. Here, we detect changes in weekly cycles of PM2.5, NO2, SO2, CO and O3concentrations in 2020 compared to 2018 and 2019 using the observed data at 32 stations in Beijing. Distinct weekly cycles of annual average PM2.5, NO2, SO2and CO concentrations existed in 2018, while the weekend effects changed in 2020. In addition, the weekly cycle magnitudes of PM2.5, NO2, SO2, and O3concentrations in 2020 decreased by 29.60–69.26% compared to 2018, and 4.49–47.21% compared to 2019. We propose that the changing weekend effects and diminishing weekly cycle magnitudes may be tied to the COVID-19 lockdown controls, which changed human working and lifestyle cycles and reduced anthropogenic emissions of air pollutants on weekends more than weekdays.
Severe atmospheric pollution in the Middle East is attributable to anthropogenic sources
Authors: Osipov Sergey , Chowdhury Sourangsu , Crowley John N. , Tadic Ivan , Drewnick Frank , Borrmann Stephan , Eger Philipp , Fachinger Friederike , Fischer Horst , Predybaylo Evgeniya , Fnais Mohammed , Harder Hartwig , Pikridas Michael , Vouterakos Panos , Pozzer Andrea , Sciare Jean , Ukhov Alexander , Stenchikov Georgiy L. , Williams Jonathan , Lelieveld Jos 
Published: September 2022

AbstractIn the Middle East, desert dust is assumed to dominate air pollution, being in permanent violation of public health guidelines. Here we present ship-borne measurements from around the Arabian Peninsula and modeling results to show that hazardous fine particulate matter is to a large extent of anthropogenic origin (>90%), and distinct from the less harmful, coarse desert dust particles. Conventionally, it was understood that desert dust dominates both the fine and coarse aerosol size fractions, which obscures the anthropogenic signal. We find that the annual excess mortality from the exposure to air pollution is 745 (514-1097) per 100,000 per year, similar to that of other leading health risk factors, like high cholesterol and tobacco smoking. Furthermore, anthropogenic pollution particles account for a major part (~53%) of the visible aerosol optical depth. Therefore, in the Middle East anthropogenic air pollution is a leading health risk and an important climatic factor.