bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resource Orchestration and Scaling‐up of Platform‐Based Entrepreneurial Firms: The Logic of Dialectic Tuning
Authors: Zeng Jing , Yang Yunlu , Lee Soo Hee 
Published: August 2022

AbstractThe emergence of platform‐based entrepreneurial firms (PBEFs) and their rapid scaling holds considerable implications for the theory and practice of firm growth in the digital economy. Building on the resource‐based view, we seek deeper insights into the question of how PBEFs orchestrate resources to scale up in the context of platform ecosystems. We conduct an in‐depth longitudinal case study of Tencent, one of the largest PBEFs in the world, and develop an inductive process model based on the logic of ‘dialectic tuning’. We uncover the specific actions and capabilities that PBEFs possess and employ to scale up a platform ecosystem, as manifested in a complementary set of concrete organizational practices enacted at different stages of the growth trajectory. We unveil an important boundary condition that has hitherto remained implicit in the literature on firm growth driven by platform‐based business models. Our findings diverge from the conventional perspective which predominantly associates firm growth with the characteristics of internal resources and capabilities. We argue that the relational properties of interaction and integration between internal and external resources are what gives rise to the capabilities needed to scale up a platform. Thus, we extend and refine the resource‐based view by explaining the evolving patterns of resource orchestration and management of PBEFs in terms of the interplay between the focal platform and its ecosystem partners.
Does the metabolizable energy influence the performance, carcass characteristics and biochemical parameters of European quails from 28 to 42 days of age?
Authors: de Jesus Monica Raline Reis , Santos Thailine Santana , Silva Camilla Mendonça , Zancanela Vittor Tuzzi , Costa Patrícia Santos , Oliveira Lima João Vitor , Ribeiro Júnior Valdir , Brito Claudson Oliveira , de Oliveira Júnior Gregório Murilo 
Published: August 2022

AbstractThis study was conducted to determine the metabolizable energy (ME) requirement for quails (Cortunix cortunix cortunix) from 28 to 42 days of age. Four hundred and twenty quails were distributed in a completely randomized design, with 5 treatments (2950, 3000, 3050, 3100 and 3150 kcal of ME/kg of feed), 7 replicates and 12 birds per experimental unit. Performance, relative weights of organs and viscera, carcass characteristics, meat quality, body composition and blood parameters of the birds were evaluated. There was a reduction in feed intake (ADFI) with the use of 3150 kcal ME/kg (p < 0.01), with a quadratic effect on feed efficiency (p < 0.01), estimating the energy requirement in the 3009.4 kcal ME/kg. The breast yield (BY) and the colour b* had an effect (p < 0.01), with better results for 2950 kcal ME/kg, while the meat texture reduced when the birds were fed with 3150 kcal ME/kg. HDL and LDL showed the quadratic effect (p < 0.01) when ME increased to 3111.6 and 3157.4 kcal/kg respectively. Very low density lipoprotein increased linearly (p < 0.01) in birds that received diets with 3000 kcal ME/kg. We conclude that the use of 3009.4 kcal of ME/kg for European quail meets the nutritional needs and provides an improvement in feed efficiency, without affecting the carcass parameters of the birds. Information regarding the nutritional requirements for European quails is still recent; therefore, it is essential to know the adequate levels of metabolizable energy, an important nutritional component for the maximum productive performance of birds.
Trust in healthcare providers among Chinese immigrants living with hepatitis B virus in Australia: A qualitative study
Authors: Jin Defeng , Brener Loren , Treloar Carla 
Published: August 2022

AbstractDespite the importance of trust in healthcare settings, there remains a paucity of evidence on the role it plays in patient–provider relationships and healthcare outcomes among people living with hepatitis B virus (HBV). International evidence suggests that Chinese immigrants living with HBV experience inequitable access, outcomes and treatment quality in chronic hepatitis B (CHB) health care. This study explores individual trust in healthcare providers and its impact on health‐seeking behaviours and health outcomes among Chinese people living with HBV in Australia. A total of 16 participants were recruited from the Chinese community in Sydney and Melbourne and participated in semi‐structured interviews. The data were analysed within a conceptual model of trust that contains five dimensions: fidelity, competence, honesty, confidentiality and global trust. The data shows how trust in physicians was formed and influenced by factors including patient–provider interactions, historically relevant experiences, health and illness beliefs and systemic barriers. While the research confirms prior findings on the impact of trust and mistrust, showing an association between low trust and treatment nonadherence, it also generates fresh insights by examining what leads to mistrust and the role of trust in shaping participants' healthcare outcomes. Findings suggest that by treating patients with respect and dignity, improving interpersonal skills and cultural competency, having open discussion on complementary and alternative medicine (CAM) treatment and protecting private information, physicians can increase patients' trust. The findings will contribute to efforts to address HBV as a health priority and increase patients' trust in healthcare providers among Chinese immigrants living with HBV.
Screening of osmotic stress-tolerant bacteria for plant growth promotion in wheat (Triticum aestivum L.) and brinjal (Solanum melongena L.) under drought conditions
Authors: Patel P. , Patil T. , Maiti S. , Paul D. , Amaresan N. 
Published: August 2022

Abstract
Drought stress adversely affects plant growth and productivity. Therefore, the application of plant growth-promoting bacteria is a viable option for combating drought resistance in crops. In this study, 144 bacteria were isolated from the Kutch desert soil in Gujarat. Based on osmotic stress tolerance and PGP properties, two strains, Bacillus tequilensis (KS5B) and Pseudomonas stutzeri (KS5C) were tested for their effect on wheat (Triticum aestivum L.) and brinjal (Solanum melongena L.) under drought stress conditions. Inoculation with osmotic stress-tolerant bacteria showed 15·15–29·27% enhancement in root length of wheat and 15·27–32·59% in brinjal plants. Similarly, the enhancement of shoot length ranged from 14·72 to 37·70% for wheat and 59·39–95·94% for brinjal plants. Furthermore, the inoculated plants showed significant improvement in chlorophyll content and antioxidant properties such as proline, peroxidase and polyphenol oxidase activity compared to the control. Therefore, the bacterial strains identified in this study can be used to mitigate drought stress and enhance plant biomass.
Meta-analysis of the microbial biomarkers in the gut–lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections
Authors: Aishwarya S. , Gunasekaran K. 
Published: August 2022

Abstract
Respiratory infections are the leading causes of mortality and the current pandemic COVID-19 is one such trauma that imposed catastrophic devastation to the health and economy of the world. Unravelling the correlations and interplay of the human microbiota in the gut–lung axis would offer incredible solutions to the underlying mystery of the disease progression. The study compared the microbiota profiles of six samples namely healthy gut, healthy lung, COVID-19 infected gut, COVID-19 infected lungs, Clostridium difficile infected gut and community-acquired pneumonia infected lungs. The metagenome data sets were processed, normalized, classified and the rarefaction curves were plotted. The microbial biomarkers for COVID-19 infections were identified as the abundance of Candida and Escherichia in lungs with Ruminococcus in the gut. Candida and Staphylococcus could play a vital role as putative prognostic biomarkers of community-acquired pneumonia whereas abundance of Faecalibacterium and Clostridium is associated with the C. difficile infections in gut. A machine learning random forest classifier applied to the data sets efficiently classified the biomarkers. The study offers an extensive and incredible understanding of the existence of gut–lung axis during dysbiosis of two anatomically different organs.
CRISPR/Cas‐based tools for the targeted control of plant viruses
Authors: Robertson Gaëlle , Burger Johan , Campa Manuela 
Published: August 2022

AbstractPlant viruses are known to infect most economically important crops and pose a major threat to global food security. Currently, few resistant host phenotypes have been delineated, and while chemicals are used for crop protection against insect pests and bacterial or fungal diseases, these are inefficient against viral diseases. Genetic engineering emerged as a way of modifying the plant genome by introducing functional genes in plants to improve crop productivity under adverse environmental conditions. Recently, new breeding technologies, and in particular the exciting CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR‐associated proteins) technology, was shown to be a powerful alternative to engineer resistance against plant viruses, thus has great potential for reducing crop losses and improving plant productivity to directly contribute to food security. Indeed, it could circumvent the “Genetic modification” issues because it allows for genome editing without the integration of foreign DNA or RNA into the genome of the host plant, and it is simpler and more versatile than other new breeding technologies. In this review, we describe the predominant features of the major CRISPR/Cas systems and outline strategies for the delivery of CRISPR/Cas reagents to plant cells. We also provide an overview of recent advances that have engineered CRISPR/Cas‐based resistance against DNA and RNA viruses in plants through the targeted manipulation of either the viral genome or susceptibility factors of the host plant genome. Finally, we provide insight into the limitations and challenges that CRISPR/Cas technology currently faces and discuss a few alternative applications of the technology in virus research.
The contribution of brain banks to knowledge discovery in amyotrophic lateral sclerosis: A systematic review
Authors: Mazumder Srestha , Kiernan Matthew C. , Halliday Glenda M. , Timmins Hannah C. , Mahoney Colin J. 
Published: August 2022

AbstractOver the past decade, considerable efforts have been made to accelerate pathophysiological understanding of fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) with brain banks at the forefront. In addition to exploratory disease mechanisms, brain banks have aided our understanding with regard to clinical diagnosis, genetics and cell biology. Across neurodegenerative disorders, the impact of brain tissue in ALS research has yet to be quantified. This review aims to outline (i) how postmortem tissues from brain banks have influenced our understanding of ALS over the last 15 years, (ii) correlate the location of dedicated brain banks with the geographical prevalence of ALS, (iii) identify the frequency of features reported from postmortem studies and (iv) propose common reporting standards for materials obtained from dedicated brain banks. A systematic review was conducted using PubMed and Web of Science databases using key words. From a total of 1439 articles, 73 articles were included in the final review, following PRISMA guidelines. Following a thematic analysis, articles were categorised into five themes; clinico‐pathological (13), genetic (20), transactive response DNA binding protein 43 (TDP‐43) pathology (12), non‐TDP‐43 neuronal pathology (nine) and extraneuronal pathology (19). Research primarily focused on the genetics of ALS, followed by protein pathology. About 63% of the brain banks were in the United States of America and United Kingdom. The location of brain banks overall aligned with the incidence of ALS worldwide with 88% of brain banks situated in Europe and North America. An overwhelming lack of consistency in reporting and replicability was observed, strengthening the need for a standardised reporting system. Overall, postmortem material from brain banks generated substantial new knowledge in areas of genetics and proteomics and supports their ongoing role as an important research tool.
Melodic Intonation Therapy for aphasia: A multi‐level meta‐analysis of randomized controlled trials and individual participant data
Authors: Popescu Tudor , Stahl Benjamin , Wiernik Brenton M. , Haiduk Felix , Zemanek Michaela , Helm Hannah , Matzinger Theresa , Beisteiner Roland , Fitch W. Tecumseh 
Published: August 2022

AbstractMelodic Intonation Therapy (MIT) is a prominent rehabilitation program for individuals with post‐stroke aphasia. Our meta‐analysis investigated the efficacy of MIT while considering quality of outcomes, experimental design, influence of spontaneous recovery, MIT protocol variant, and level of generalization. Extensive literature search identified 606 studies in major databases and trial registers; of those, 22 studies—overall 129 participants—met all eligibility criteria. Multi‐level mixed‐ and random‐effects models served to separately meta‐analyze randomized controlled trial (RCT) and non‐RCT data. RCT evidence on validated outcomes revealed a small‐to‐moderate standardized effect in noncommunicative language expression for MIT—with substantial uncertainty. Unvalidated outcomes attenuated MIT's effect size compared to validated tests. MIT's effect size was 5.7 times larger for non‐RCT data compared to RCT data (g̅case report = 2.01 vs. g̅RCT = 0.35 for validated Non‐Communicative Language Expression measures). Effect size for non‐RCT data decreased with number of months post‐stroke, suggesting confound through spontaneous recovery. Deviation from the original MIT protocol did not systematically alter benefit from treatment. Progress on validated tests arose mainly from gains in repetition tasks rather than other domains of verbal expression, such as everyday communication ability. Our results confirm the promising role of MIT in improving trained and untrained performance on unvalidated outcomes, alongside validated repetition tasks, and highlight possible limitations in promoting everyday communication ability.
Productivity Slowdown in Japan's Lost Decades: How Much of It Can Be Attributed to Damaged Balance Sheets?*
Authors: Muto Ichiro , Sudo Nao , Yoneyama Shunichi 
Published: August 2022

AbstractAfter the global financial crisis, slowdowns of total factor productivity (TFP), often measured as the Solow residual, have been observed across major countries. This study offers an explanation for this by focusing on Japan's financial crises during the 1990s. We first incorporate credit constraints, for financial intermediaries (FIs) and firms, and input–output structure into the standard New Keynesian model, and show that the model delivers multiple channels through which damaged balance sheets reduce measured TFP. We then estimate the model using Japanese data, and show that adverse shocks to FIs' balance sheets played a substantial role in lowering measured TFP.
Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma
Authors: Xu Shuang‐Bo , Wang Meng‐Yao , Shi Xin‐Zhan , Wang Qiong , Yu Miao , Zhang Wei , Xu Xiao‐Hui , Liu Lai‐Kui 
Published: August 2022

AbstractObjectiveTo evaluate the relation between the expression of PD‐1, PD‐L1, CD3, CD8, Foxp3 and clinicopathological features in patients with oral leukoplakia (OLK) and oral squamous cell carcinomas (OSCC) as well as the malignant outcome in OLK patients, and to study the effect of PD‐1 and PD‐L1 on immune microenvironment in the progression of oral carcinogenesis.MethodsWe evaluated the expression of PD‐1/PD‐L1 and composition of CD3+, CD8+and Foxp3+ T lymphocytes in OLK and OSCC samples by immunohistochemical (IHC) staining and analyzed their relation with clinical information and malignant transformation in OLK patients.ResultsIHC staining demonstrated that the expression of PD‐1 was significantly increased in the high‐grade OLK group than in the low‐grade OLK group, while PD‐L1 was detected mainly in OSCC. The expression of CD3, CD8, and Foxp3 was found higher in the high‐grade OLK group than in the low‐grade OLK group, and the Foxp3+ cells were found more in the OSCC group than in the high‐grade OLK group. PD‐1 was significantly correlated with CD3 (p < 0.05, R = 0.52), CD8 (p < 0.05, R = 0.46), and Foxp3 (p < 0.05, R = 0.46), and the low PD‐1‐expression group showed a better malignant‐free survival than high PD‐1 expression group in the OLK (p < 0.05).ConclusionThe PD‐1/PD‐L1 may induce immune suppression in OLK and accelerate the progress of malignant transformation.
Processes in international relationships: A critical review
Authors: Gaines Stanley O. 
Published: August 2022

AbstractIn the present review, the author draws upon Bell's (1987) critical race theory – especially as reflected in Crenshaw's (1989) construct of intersectionality – en route to examining the results of four studies of international relationship processes that have been published since 2002 (i.e., Holzapfel et al., 2018; Kaya et al., 2019; Kuramoto, 2018 and van Mol & de Valk, 2016). One common theme that emerged from the four studies was the importance of satisfaction‐related processes in international relationships – a theme that Thibaut and Kelley's (1959) interdependence theory would anticipate within intranational and international relationships alike. Although persons from African, Central American, and South American nations are conspicuously missing from the studies in question, the author does not attribute such omissions to structural racism. Implications for future research on inclusivity and the dynamics of international relationships are discussed.
Hooker's rule‐consequentialism and Scanlon's contractualism—A re‐evaluation
Authors: Suikkanen Jussi 
Published: August 2022

AbstractBrad Hooker's rule‐consequentialism and T. M. Scanlon's contractualism have been some of the most debated ethical theories in normative ethics during the last twenty years or so. This article suggests that these theories can be compared at two levels. Firstly, what are the deep, structural differences between the rule‐consequentialist and contractualist frameworks in which Hooker and Scanlon formulate their views? Secondly, what are the more superficial differences between Hooker's and Scanlon's formulations of these theories? Based on exploring these questions and several purported differences between Hooker's and Scanlon's views, this article argues that, at the structural level, the two theories are more similar than previous recognised. It suggests that there is only one candidate for a deeper difference and even it may not be that significant. This insight sheds new light on both contractualism and rule‐consequentialism, and it will also help us to formulate better versions of the views.
Foreign market entry, upstream market power, and endogenous mode of downstream competition
Authors: Gilbert John , Koska Onur A. , Oladi Reza 
Published: August 2022

AbstractIn a differentiated duopoly model of trade and FDI featuring both horizontal and vertical product differentiation, we examine whether globalization and trade policy measures can generate welfare gains by leading firms to change their mode of competition. We show that when a high‐quality foreign variety is manufactured under large frictions due to upstream monopoly power, a foreign firm can become a Bertrand competitor against a Cournot local rival in equilibrium, especially when the relative product quality of the foreign variety is sufficiently high and trade costs are sufficiently low (implying higher input price distortions due to double marginalization). Our results suggest that such strategic asymmetry is welfare improving and that the availability of FDI as an alternative to trade can make welfare‐enhancing strategic asymmetry even more likely, especially when both input trade costs and fixed investment costs are sufficiently low and trade costs in final goods are sufficiently large.
General higher—order breathers and rogue waves in the two‐component long‐wave–short‐wave resonance interaction model
Authors: Rao Jiguang , Malomed Boris A. , Mihalache Dumitru , He Jingsong 
Published: August 2022

AbstractGeneral higher order breather and rogue wave (RW) solutions to the two‐component long wave–short wave resonance interaction (2‐LSRI) model are derived via the bilinear Kadomtsev–Petviashvili hierarchy reduction method and are given in terms of determinants. Under particular parametric conditions, the breather solutions can reduce to homoclinic orbits, or a mixture of breathers and homoclinic orbits. There are three families of RW solutions, which correspond to a simple root, two simple roots, and a double root of an algebraic equation related to the dimension reduction procedure. The first family of RW solutions consists of bounded fundamental RWs, the second family is composed of bounded fundamental RWs coexisting with another fundamental RWs of different a bounded state ( being positive integers), while the third one has fundamental bounded RWs ( being nonnegative integers). The second family can be regarded as the superpositions of the first family, while the third family can be the degenerate case of the first family under particular parameter choices. These diverse RW patterns are illustrated graphically.
Differential preferences for RBCs is key for Plasmodium species evolutionary diversity within human host
Authors: Djidjou‐Demasse Ramsès , Mann‐Manyombe Martin L. , Seydi Ousmane , Yatat‐Djeumen Valaire 
Published: August 2022

AbstractPlasmodium species exhibit differential preferences for red blood cells (RBCs) of different ages. From a fundamental standpoint, we propose an age‐structured within‐host malaria model taking into account the variation in RBCs preference. We show that such a differential ecological characteristic of Plasmodium species within their human host is fundamental to capture species diversity within the same infected host individual. We show that with such difference in the RBCs preferences, the long‐term coexistence of different species is possible under a certain condition, basically based on a suitable order on the basic reproduction numbers of each species. In particular, we show that the dynamical behavior of the model is not trivial and can range from the extinction of all species, the persistence of a single species, to the coexistence of more than one species. We also describe how our general analysis can be applied in some coinfection configurations including three malaria species: Plasmodium falciparum, Plasmodium vivax, and/or Plasmodium malariae. This improved understanding of the within‐host parasite multiplication in a context of mixed Plasmodium species interactions.