bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic Factors Associated with Long-Term Glaucoma Progression – 10-year follow-up results based on electronic medical records
Authors: Yoon Jung Suk , Lee Eun Ji , Kim Hyungjoong , Kim Tae-Woo 
Published: July 2022

Abstract
Glaucoma is a multifactorial disease where various systemic features are involved in the progression of the disease. Based on initial systemic profiles in electronic medical records (EMRs), this study aimed to develop a model predicting factors of long-term rapid retinal nerve fiber layer (RNFL) thinning over 5 years in 505 patients with primary open-angle glaucoma. Eyes with faster or slower RNFL thinning were stratified using a decision-tree model, and systemic and ophthalmic data were incorporated into the models based on random forest and permutation methods, with the models interpreted by Shapley additive explanation plots (SHAP). According to decision tree, higher lymphocyte ratio (> 34.65%) was the most important systemic variable discriminating faster or slower RNFL thinning. Higher mean corpuscular hemoglobin (> 32.05 pg) and alkaline phosphatase (> 88.0 IU/L) concentrations were distinguishing factors in the eyes with lymphocyte ratios > 34.65% and < 34.65%, respectively. SHAP demonstrated larger baseline RNFL thickness, greater fluctuation of intraocular pressure (IOP), and higher maximum IOP as strongest ophthalmic factors, while higher lymphocyte ratio and higher platelet counts as strongest systemic factors associated with faster RNFL thinning. Machine learning-based modeling identified several systemic factors as well as previously acknowledged ophthalmic risk factors associated with long-term rapid RNFL thinning.
Comparing perioperative outcomes of robotic-assisted laparoscopic adrenalectomy and laparoscopic adrenalectomy in the treatment of large adrenal tumors (≥5 cm): a propensity-matched score analysis
Authors: Yang Lin , Wu Yao , Li Sheng , Liu Xiao Qiang , Deng Wen , Liu Weipeng , Fu Bin 
Published: July 2022

Abstract
Introduction:
At present, the advantages of robotic-assisted laparoscopic adrenalectomy over laparoscopic adrenalectomy for large adrenal tumors (≥ 5 cm) are still controversial. Our study aimed to clarify whether robotic-assisted laparoscopic adrenalectomy has significant advantages.
Materials and methods
A total of 244 patients with adrenal tumors ≥ 5 cm who underwent minimally invasive surgery in our hospital from 2010 to 2021 were included in this study. There were 77 patients in the robotic-assisted laparoscopic adrenalectomy group and 167 patients in the laparoscopic adrenalectomy group. After propensity score matching, each group included 77 patients.
Results
There were no significant differences between the groups, in postoperative morbidity (p = 0.125)、estimated blood loss (p = 0.678)、operative time (p = 0.451), and postoperative hospital stay ( p = 1.000). The rate of conversion to open surgery in the robotic-assisted laparoscopic adrenalectomy group was significantly lower than that in the laparoscopic adrenalectomy group [0(0.0%) vs 6(7.8%), p = 0.031]. However, the total hospitalization cost in the robotic-assisted laparoscopic adrenalectomy group was significantly higher than that in the laparoscopic adrenalectomy group [53452 (46717, 60499) vs 33196 (27317, 41521), p < 0.001].
Conclusions
Both robotic-assisted laparoscopic adrenalectomy and laparoscopic adrenalectomy are safe and effective in the treatment of large adrenal tumors. If the risk of conversion to open surgery is high, robotic-assisted laparoscopic adrenalectomy should be the first choice.
A thematic analysis of mental health, addiction and gambling discussion on Reddit during the recent cryptocurrency market downturn
Authors: Johnson Benjamin , Stjepanović Daniel , Leung Janni , Sun Tianze , Chan Gary C. K. 
Published: July 2022

Abstract
Purpose
Considering the volatility of the cryptocurrency market, it is important to investigate the impact that market participation has on mental health. Therefore, we analyzed Reddit discussions regarding mental health, gambling, and addiction from members of the cryptocurrency discussion board, r/cryptocurrency, during a recent downturn in the cryptocurrency market.
Methods
We collected 1315 threads submitted to the subreddit r/cryptocurrency between January 3rd to February 4th. A thematic analysis was employed, which included threads that discussed psychological wellbeing, mental health or gambling.
Results
We thematically analyzed the content of 130 threads, which contained 7635 comments. Our analysis identified three main themes present in user discussion. Theme 1 (emotional state and mental health) captured users' discussion on their wellbeing, mental health and emotional responses to the market downturn. Theme 2 (strategies for coping) examined coping strategies recommended by users to combat distress to the market conditions or trading urges. Theme 3 (likeness to gambling) captured discussion on the relationship between cryptocurrency and gambling based on its fixating properties and risk profile.
Conclusions
Reddit is a valuable resource for examining the experiences and attitudes of the cryptocurrency community. Accounts of Reddit users' experiences provided insight into the mental distress market downturns can cause and strategies to combat problems due to trading. Our findings offer qualitative insights into the problems experienced by individuals who cryptocurrency trade and encourage further investigation into its relationship with mental health.
Assessing Parental Marital Quality and Divorce Related to Youth Sexual and Reproductive Health among 50,000 Chinese College Students
Authors: Wang Wen , Yin Ruoyu , Cao Wenzhen , Wang Yu , Zhang Tingkai , Yan Yan , Tang Kun 
Published: July 2022

Abstract
Background: This study aimed to investigate the associations between parental marital quality, divorce and sexual and reproductive health outcomes among Chinese young people.Methods: The study included 51,124 students from a large-scale cross-sectional study in China from 2019 to 2020. The exposure is parental marital quality and marital status reported by students. The outcomes are dichotomous variables, including sexual experiences, high-risk sexual behaviors, unintended health outcomes and sexual abuse. Multivariate logistic regression was used to assess the relationship between parental marital quality, divorce and sexual and reproductive health outcomes, stratified by sex and adjusted by socio-demographic covariates.Results: The prevalence of students' parents who had been divorced was 10.72%, and the divorced family group rated perceived parental marital quality less than half of the ratings of the intact family group. Results showed that parental divorce was associated with a higher likelihood of sexual abuse, high-risk sexual behaviours, and unintended health outcomes. A higher perceived parental marital quality was associated with a lower probability of poorer sexual and reproductive health outcomes, such as forced penetrative vaginal or anal intercourse (male: OR: 0.73, 95%CI: 0.64-0.83; female: OR:0.71, 95%CI: 0.65-0.77), casual sexual intercourse (male: OR: 0.78, 95%CI: 0.73-0.83; female: OR: 0.77, 95%CI: 0.72-0.83), and sexually transmitted infections (male: OR: 0.79, 95%CI: 0.70-0.89; female: OR: 0.82, 95%CI: 0.73-0.91).Conclusions: Parental marital quality and status are associated with poorer sexual and reproductive health outcomes among young people, suggesting that specific intervention programmes should be implemented for those children from unharmonious families or divorced families to prevent adverse sexual and reproductive health outcomes.
Comparative transcriptomic analysis of the larval and adult stages of Dibothriocephalus dendriticus (Cestoda: Diphyllobothriidea)
Authors: Sidorova Tuyana Valeryevna , Kutyrev Ivan Alexandrovich , Khabudaev Kirill Vladimirovich , Sukhanova Lubov Vasilyevna , Zheng Yadong , Dugarov Zhargal Nimaevich , Mazur Olga Evgenievna 
Published: July 2022

Abstract
Tapeworms of the genus Dibothriocephalus are widely distributed throughout the world, some of which are agents of human diphyllobothriasis, one of the most important fish-borne zoonoses caused by a cestode parasite. Genomic and transcriptomic data can be used to develop future diagnostic tools and epidemiological studies. The present work focuses on a comparative analysis of the transcriptomes of adult and plerocercoid D. dendriticus and the identification of their differentially expressed genes (DEGs). Transcriptome assembly and analysis yielded and annotated 35129 unigene, noting that 16568 (47%) unigene were not annotated in known databases, which may indicate a unique set of expressed transcripts for D. dendriticus. A total of 8022 differentially expressed transcripts were identified, including 3225 upregulated and 4797 downregulated differentially expressed transcripts from the plerocercoid and adult animals. The analysis of DEGs has shown that among the most differentially expressed genes there are important genes characteristic of each stage. Thus, several genes are characteristic of D. dendriticus plerocercoides, including fatty acid-binding protein and ferritin. Among the most highly expressed DEGs of the adult stage of D. dendriticus is the Kunitz-type serine protease inhibitor, in two putative isoforms. The analyses of GO and KEGG metabolic pathways revealed that a large number of the DEGs of D. dendriticus are associated with the biosynthesis of various substances such as arginine and folate, as well as with various metabolic pathways such as galactose metabolism, selenocompound metabolism, phosphonate and phosphinate metabolism. This will contribute to further research aimed at identifying targets for new generation drugs and the development of specific vaccines.
Health Value of China’s Long-term Care Insurance in Older Disabled People: Role of Institutional Care
Authors: Zhou JinQiu , Zhu Bin , Yan YuHua , Hou LiSha , Wu JinHui , Dong BiRong , Dou QingYu 
Published: July 2022

Abstract
BackgroundSince the public long-term care insurance (LTCI) system was piloted in Chengdu, China in July 2017, there has been a considerable growth of LTC institutions in China. This study aimed to evaluate the health value effect of LTCI in older patients with severe disabilities in an LTC institution.MethodsThis study was based on data from 985 severe disability patients with or without LTCI from July 2017 to October 2020 in the Eighth People's Hospital, Chengdu, China. The Cox proportional hazard model estimated LTCI’s health value, including survival probability and risk of pneumonia/pressure ulcers. Subgroup analysis was performed for sex, age, Charlson Comorbidity Index (CCI), and the number of drugs.OutcomeIn the analysis 519 and 466 patients in LTCI and non-LTCI groups, respectively, were included. In adjusted Cox analyses, the LTCI group had a significantly elevated survival rate compared at 12 months (P<0.001, OR=1.758, 95% CI 1.300-2.376). At 40 months, the adjusted survival rate was 62.6% in the LTCI group, which was significantly higher (53.7%; P=0.003, OR=1.438, 95% CI 1.131-1.831). The subgroups of patients aged 60 to 79 years (interaction P=0.007) and CCI≥3 (interaction P=0.026) were more significantly associated with survival improvement than those aged >80 years and CCI< 3. The LTCI group was also at lower risk for hospital-acquired pneumonia (P=0.016, HR 0.622, 95% CI 0.422-0.917) and pressure ulcers (P=0.008, HR 0.695, 95% CI 0.376-0.862). The improved survival of LTCI remained stable in sensitivity analyses.ConclusionFor older patients with severe disabilities, in a long-term care institution, LTCI significantly improved their health profile and longevity after a year, suggesting the large role and development potentiality of institution care in the LTCI system of China.
Cryptosporidium in Dairy Cattle, Sheep, Humans, and Manure in and around Adama and Asella Towns, Oromia Regional State, Ethiopia
Authors: Berhanu Kassahun , Ayana Dinka , Megerssa Bekele 
Published: July 2022

Abstract
In Ethiopia, several studies have reported the occurrence of Cryptosporidium infection in young calves, lambs, and HIV positive patients. However, studies on cattle and sheep of all age categories, and humans (farm workers and animal owners) were limited. A cross-sectional study design was thus conducted from October 2021 to April 2022 to study the occurrence of Cryptosporidium in dairy cattle, sheep, humans, and manure in and around Adama and Asella towns, Oromia, Ethiopia. Dairy cattle and sheep were stratified according to their age and randomly sampled. Stool samples from volunteered farm workers and household members were collected purposefully. A semi-structured questionnaire was also used to collect information about manure handling practices. All samples (dairy cattle = 234, sheep = 200, humans = 56, manure = 58) were processed with sugar floatation technique and the modified Ziehl-Neelsen staining method. A univariate regression analysis was used to test the association of individual factors with the occurrence of Cryptosporidium. Associated factors were subjected to multivariate regression analysis to identify potential risk factors. The overall prevalence of Cryptosporidium in dairy cattle, sheep, humans, and manure was 20.5%, 14%, 16%, and 13.20%, respectively. The occurrence of Cryptosporidium infection in dairy cattle at the ages of 1–12 months and 13–36 months was 3.48 and 3.07 times higher, respectively, in comparison to the age above 36 months. Similarly, the occurrence was 2.69 times higher in sheep aged 1–6 months than in those aged older than 6 months. And also, a higher average level of oocyst count (above 10 oocysts) per-field was examined in dairy cattle (3/48) aged 1–12 months, followed by sheep (1/28) aged 1–6 months. Furthermore, the likelihood of infection was 13 times greater in farm workers compared with the rural farmer members. In addition, the occurrence of oocysts was 22.8 times higher in manures from dairy cattle than manure from sheep. From data on manure handling practices, only 16.8% of them had manure storage holes, 98.1% used manure for crop production, and all of them used manure without treatment. The current study revealed the occurrence of Cryptosporidium infection in all age groups of dairy cattle and sheep, farm workers, animal owners, and manures. Therefore, more studies on adult animals and manure is required to investigate their contribution to environmental contamination as well as their role as a source of infection in young calves and lambs. In addition, molecular characterization is also required to identify the zoonotic species of Cryptosporidium.
Monthly Pan Evaporation Modelling using Hybrid machine learning algorithms in a semi-arid environment
Authors: Al-Mukhtar Mustafa , Elbeltagi Ahmed , Kushwaha N. L. , Vishwakarma Dinesh Kumar 
Published: July 2022

Abstract
Evaporation is one of the most critical hydrologic processes that have direct impacts on agricultural efficiency, the planning and operation of water resources projects. Hence, an accurate estimation of evaporation is essential for proper management of water resources. However, the non-linearity, non-stationary, and stochastic features of the evaporation process constitute the major problem in developing reliable and robust predictive models. As such, machine learning (ML) algorithms has been identified as efficient alternative methods to overcome such as complexity. The purpose of this study was to explore the applicability of coupling the additive regression model (AR) with four different machine-learning algorithms- Random Subspace (RSS), M5 Pruned (M5P), Reduced Error Pruning Tree (REPTree), and Bagging for predicting pan evaporation rates. The evaluated methods were applied using data from three different agroclimatic stations in Iraq i.e. Baghdad, Mosul, and Basrah. The best-input combinations were determined using the regression model. Results revealed that the best predictions are achieved by incorporating wind speed, relative humidity, the minimum, and mean temperatures. All the ML models performed well in predicting evaporation at the investigated locations. However, the AR-M5P was found to be the best performance among the other evaluated methods. The statistical indices MAE, RMSE, RAE, RRSE, and r from AR-M5P at Baghdad- Mosul during testing were 33.82, 45.05, 24.75, 28.50, and 0.972–25.82, 35.95, 23.75, 29.64, and 0.956, respectively. The findings of this study demonstrated the superior performance of the applied methods which can be employed to address other environmental problems.
Utility of PCR in the Diagnosis of Tubercular Lymphadenitis on Fine Needle Aspirates
Authors: Fernandes Hilda , Shetty Anup Kumar , . Archana 
Published: July 2022

Background
Extra-pulmonary tuberculosis is a diagnostic and therapeutic challenge. Diagnosing tubercular lymphadenitis includes identification of epithelioid granulomas, positive Acid Fast Bacilli detected with Ziehl Neelsen’s stain. The disadvantage is the time taken for formation of granulomas. With the advent of RT-PCR, the diagnosis of tubercular lymphadenitis can be made with ease [1].
Aims and objectives: To utilize PCR and mycobacterial culture on samples obtained from Fine needle aspiration of lymph nodes in order to aid in early diagnosis of extra-pulmonary tuberculosis.
Materials and methods: Observational descriptive prospective study; Patients with lymphadenopathy >1 cm, above the age of 2 years were included ; FNA was performed, material was used for routine cytological studies (PAP, MGG and Ziehl Neelsen-stained slides), PCR and culture (wherever possible); Comparative values of PCR and culture were utilized for statistical analysis
Results: Out of 80 cases studied, M. Tuberculosis by PCR was detected on 36 cases (45%); PCR and culture demonstrated MTB in 42.55% of the cases. 9 cases (11.25%) of reactive lymphadenitis were found to be of tubercular etiology on PCR analysis. The Chi-squared test was highly significant. PCR has been found to have a sensitivity, specificity, PPV and NPV of 100%, 92.59%, 90.91% and 100%, respectively. Positive RT-PCR was more common in cases with chronic granulomatous inflammation when compared against reactive lymphoid hyperplasia with a chronic inflammatory infiltrate.
Conclusion: From this study, we conclude that RT-PCR is a useful ancillary technique to conclusively identify Mycobacterium tuberculosis in samples obtained from fine needle aspiration of lymph nodes.
Variety productivity of Phaseolus vulgaris L. for green pods in the Forest-Steppe of Ukraine
Authors: Yatsenko V. V. , Vorobiova N. V. , Yatsenko A. O. 
Published: July 2022

Purpose. To reveal the features of productivity formation of French bean varieties of different ecological and geographical origin in the conditions of the Forest-Steppe of Ukraine.
Methods. During 2020–2021 six early maturing varieties of beans – ‘Zironka’, ‘Casablanca’ (Ukraine), ‘Lila Königin’ (Germany), ‘Laura’ (Poland), ‘Fruidor’ (France) and ‘Paloma’ (the Netherlands) were studied in the field (Uman, 48°46’N, 30°14’E). Biometric and productivity indicators of plants, as well as the biochemical composition of products (green beans) were analyzed in technical and full maturity of the culture (BBCH 75 and 99).
Results. The dwarf varie­ties ‘Lila Königin’ and ‘Casablanca’ were identified, which can be used in breeding as a source of this trait. Varieties with high attachment of the lower bean, suitable for mechanized harvesting – ‘Casablanca’, ‘Zironka’, ‘Laura’ and ‘Paloma’ were identified. It was revealed that the most productive varieties were ‘Zironka’, ‘Casablanca’ and ‘Paloma’, the mass of beans in which was in the range of 43.1–86.0 g, and the yield of green beans was 9.39–19.35 t/ha. In terms of seed yield, the varieties ‘Zironka’ turned out to be highly productive – 3.51 t/ha, ‘Casablanca’ – 3.78 t/ha and ‘Lila Königin’ – 2.65 t/ha. Evaluation of the biochemical composition of green beans of French bean did not allow to distinguish varieties by a set of indicators, however, as a source of traits with a high percentage of dry residue stood out variety ‘Paloma’ – 11%; by the share of protein – ‘Fruidor’ – 18.7%; for the share of sugars – ‘Lila Königin’ – 2.60%, for the content of ascorbic acid ‘Fruidor’ – 23.0 mg/100 g and with low content of nitrates – the variety ‘Lila Königin’ – 129.0 mg/kg.
Conclusions. The evaluation of French bean varieties by morphological variability and productivity allowed to recommend ‘Paloma’ and ‘Casablanca’ varieties for use in production. Varie­ties with improved biochemical parameters that can be used as sources of traits for breeding were identified.
Improvement of a prosecutor’s participation in the conducting operative search cases by the units, that conduct operative search measures
Authors: Tikhonov Serhii , Vasylyncnuk Viktor , Vyshnevskyi Serhii 
Published: July 2022

In the course of normative-legal improvement of operative search activity (further OSA) role of the Prosecutor’s Office should be extended with processual supplement of operative search cases. It would be wise to attach in the law a provision that would oblige the heads of operational units in case of fixation operational and investigative measures information about the preparation or commission of a criminal offense, immediately notify the prosecutor (who oversees compliance with the law during operative and search activities) for the acceptance the decision about making changes to the Unite register of Pre-Trial investigations (URPI).
For a prosecutor (who is informed with the operative search case since the moment of its creation) it would be much easier to find existence or absence the signs of criminal in given materials of OSA and to accept the right decision. For the investigator or processual head who do not have access to the case it would be much harder.
The proposed changes will significantly reduce the time required for the prosecutor to make a decision on the registration of information in the URPI. Also they will have an influence on quality of information and acceptance of right processual decisions including right chose of body of Pre-Trial investigation.Except that due to the mentioned before causes the prosecutor who conduct the observation of legality during OSA should be appointed as processual head or included in the group of processual heads in case if according to the criminal proceedings some information is enrolled to the URPI. Due to the fact that the relevant law provides for the supervision of prosecutors over the observance of laws by the bodies, that make OSA and according the norms and rules mentioned in the law of Ukraine about operative search activity it is necessary that proposed changes were made directly in the law, that regulate OSA.
It would be reasonable to anticipate in the Law of Ukraine about operative search activity that in order to prevent the simultaneous conducting of operational and search measures that partially restrict the human rights of one person by different subjects of operational and investigative activities, the Office of the Prosecutor General may maintain a secure register of operational proceedings.