bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of different concentrations of titanium dioxide and copper oxide nanoparticles on water sorption and solubility of heat‐cured PMMA denture base resin
Authors: Giti Rashin , Firouzmandi Maryam , Zare Khafri Neda , Ansarifard Elham 
Published: January 2022

AbstractObjectivesThis study aimed to evaluate the effect of different concentrations of titanium dioxide (TiO2) and copper oxide (CuO) nanoparticles on the water sorption and solubility of heat‐cured polymethyl methacrylate (PMMA).Materials and MethodsFifty disc‐shaped specimens (10 × 2 mm) of heat‐cured PMMA were prepared and divided into five groups (n = 10) to be modified with 2.5 wt.% or 7.5 wt.% of either TiO2 or CuO nanoparticles. One group was left unmodified, serving as the control group. Water sorption and solubility were measured by weighing the specimens before and after immersion in distilled water and desiccation. The data were analyzed by using one‐way ANOVA and Tukey's post hoc test (α = .05).ResultsThe 2.5 wt.% CuO nanoparticles significantly decreased the water sorption (p = .016), but did not change the water solubility (p = .222) compared with the control group. The 7.5 wt.% CuO and both concentration of TiO2 nanoparticles did not change the water sorption, but significantly increased the solubility of heat‐cured PMMA (p ≤ .05).ConclusionAdding 2.5 wt.% CuO nanoparticles to heat‐cured PMMA decreases the water sorption; although, it has no significant effect on the solubility. Likewise, 2.5 and 7.5 wt.% TiO2 and 7.5 wt.% CuO do not affect the water sorption, but increase the water solubility of heat‐cured PMMA.Clinical SignificanceReinforcing the heat‐cured PMMA denture base resin materials with the right concentration and type of nanoparticles can decrease the water sorption of resin base materials, and consequently can influence the durability of dentures.
Interaction of dust ion acoustic solitons with cubic nonlinearity in a magnetized dusty plasma with () distributed electrons
Authors: Shohaib Muhammad , Masood Waqas , Jahangir Rabia , Siddiq Mohsin , Rizvi Haider 
Published: January 2022

AbstractDust ion acoustic waves (DIAWs) are analysed in multi‐component plasmas via reductive perturbation technique comprising inertial ions, (r, q) distributed electrons, and stationary dust by using fluid theory of plasmas. The modified Kadomtsev‐Petviashvili (MKP) equation is obtained for the critical condition at which the quadratic nonlinearity vanishes. Hirota's bilinear formalism is employed, for the first time, to study the two‐soliton solutions of MKP equation in the context of plasma physics. The effects of flatness at low energy (represented by ) and superthermality at high energy (represented by ) of electrons in phase space are investigated for the linear and nonlinear propagation of DIAWs. It is found that the amplitude of the nonlinear DIAW is highest for the flat‐topped distribution, whereas it is lowest for kappa distribution. Using the plasma parameters of Saturn's B‐ring. The estimates are given of the spatial scales over which the MKP solitons form for flat‐topped, kappa, and Maxwellian distributions, respectively. It is also discussed in detail how the presence of dust and non‐Maxwellian electron distributions affect the interaction of MKP solitons in Saturn's B‐ring. In addition, the interaction of a compressive and rarefactive soliton is studied giving results not achievable for KdV and KP equations.
The new and old: Atopic dermatitis biologics
Authors: Logas Christopher M. , Glick Brad P. , Del Rosso James Q. 
Published: January 2022

AbstractSevere atopic dermatitis (AD) is difficult to manage with use of topical approaches alone, often requiring use of systemic therapy at some point during the disease. Thus, the development of targeted therapies that effectively and safely reduce the signs and symptoms of AD are very important. As our understanding of the pathophysiology of AD expands based on advances in research, newer therapies are being developed that inhibit specific cytokines, chemokines, and/or receptors. With the effective response many patients have had to Dupilumab, first FDA approved biologic for AD that blocks IL‐4 and IL‐13, it has led to exciting research in inhibition of multiple other cytokines and pathways including IL‐13, IL‐31, OX40/TSLP, GBR 830, IL‐33, and Th22.
Influence of developmental nicotine exposure on serotonergic control of breathing‐related motor output
Authors: Wollman Lila , Hill Andrew , Hasse Brady , Young Christina , Hernandez‐De La Pena Giovanni , Levine Richard B , Fregosi Ralph F. 
Published: January 2022

AbstractSerotonin plays an important role in the development of brainstem circuits that control breathing. Here, we test the hypothesis that developmental nicotine exposure (DNE) alters the breathing‐related motor response to serotonin (5HT). Pregnant rats were exposed to nicotine or saline, and brainstem–spinal cord preparations from 1‐ to 5‐day‐old pups were studied in a split‐bath configuration, allowing drugs to be applied selectively to the medulla or spinal cord. The activity of the fourth cervical ventral nerve roots (C4VR), which contain axons of phrenic motoneurons, was recorded. We applied 5HT alone or together with antagonists of 5HT1A, 5HT2A, or 5HT7 receptor subtypes. In control preparations, 5HT applied to the medulla consistently reduced C4VR frequency and this reduction could not be blocked by any of the three antagonists. In DNE preparations, medullary 5HT caused a large and sustained frequency increase (10 min), followed by a sustained decrease. Notably, the transient increase in frequency could be blocked by the independent addition of any of the antagonists. Experiments with subtype‐specific agonists suggest that the 5HT7 subtype may contribute to the increased frequency response in the DNE preparations. Changes in C4VR burst amplitude in response to brainstem 5HT were uninfluenced by DNE. Addition of 5HT to the caudal chamber modestly increased phasic and greatly increased tonic C4VR activity, but there were no effects of DNE. The data show that DNE alters serotonergic signaling within brainstem circuits that control respiratory frequency but does not functionally alter serotonin signaling in the phrenic motoneuron pool.
Organophotocatalytic Intramolecular Formal Enyne‐Metathesis – An Alternative to Transition‐Metal Catalysis
Authors: de Souza Wanderson C. , Correia José Tiago M. , Matos Priscilla M. , Kisukuri Camila M. , Carneiro Pablo S. , Paixão Márcio W. 
Published: January 2022

AbstractA new approach to access 1,3‐diene derived quinolinone compounds has been realized using a mild reaction protocol employing a metal free catalyst (1,2,3,5‐tetrakis(carbazol‐9‐yl)‐4,6‐dicyanobenzene) (4CzIPN), blue LED as activation source, and benefits from a sustainable solvent dimethylcarbonate (DMC). The mechanism is postulated as an amide‐tethered enyne intramolecular [2+2]‐photocatalyzed cycloaddition‐retrocycloaddition sequence, proceeding via a cyclobutene intermediate species. The methodology offers an efficient route towards decorated 1,3‐diene products.
Stable copper‐based 2D perovskite (NH3C3H6NH3)CuBr4 thin film processed from green solvent for thermoelectric application
Authors: Kang Zhenjing , Xiong Hao , Wu Bo , Jiang Linqin , Fan Baodian , Yang Aijun , Sa Baisheng , Li Jiansheng , Lin Lingyan , Qiu Yu 
Published: January 2022

AbstractGreat achievements about lead‐based halide perovskites have been made in the fields of photovoltaic solar cells, light emitting diodes, photodetectors, and thermoelectric devices. However, the toxicity and instability of lead‐based materials hinder their practical application. Herein, we used propane‐1,3‐diammonium cation to construct a copper‐based halide perovskite material (NH3C3H6NH3)CuBr4 with a two‐dimensional layered structure. This material exhibits a suitable bandgap of 1.71 eV for a broad‐band absorption. Dense and flexible (NH3C3H6NH3)CuBr4 thin film can be obtained by simple spin‐coating of the solution using green solvent DMSO. Furthermore, (NH3C3H6NH3)CuBr4 shows excellent stability towards temperature, humidity and UV‐light. Finally, the (NH3C3H6NH3)CuBr4 thin film shows a reasonable Seebeck coefficient of −13.8 μV K−1 and a power factor of 1.70 μW m−1 K−2 at 298 K, demonstrating the great potential for flexible n‐type thermoelectric application.image
Multi‐step reflection principle and barrier options
Authors: Lee Hangsuck , Lee Gaeun , Song Seongjoo 
Published: January 2022

AbstractThis paper examines a class of barrier options, multi‐step barrier options, which can have any finite number of barriers of any level. We obtain a general, explicit expression for option prices of this type under the Black–Scholes model by deriving the multi‐step reflection principle, that is, the multi‐step boundary‐crossing probability of Brownian motion. Multi‐step barrier options are not only useful in that they can handle barriers of different levels and time steps but can also approximate options with arbitrary barriers. Moreover, they can be applied to pricing barrier options under jump‐diffusion models.
Anatomy of the sphenoidal spine and its implications in endoscopic endonasal surgery of the infratemporal fossa
Authors: Li Lifeng , London Nyall R. , Prevedello Daniel M. , Carrau Ricardo L. 
Published: January 2022

AbstractBackgroundThe sphenoidal spine protrudes from the roof of the infratemporal fossa (ITF). This study aims to assess the anatomic relationships among the sphenoidal spine and other structures within the ITF from the perspective of an endoscopic endonasal access (EEA), and to explore the implications of these relationships.MethodsAn EEA to the ITF was completed on six cadaveric specimens (12 sides). The anatomical relationships among the sphenoidal spine and adjacent structures were explored and associated distances from each other were measured using a navigation system.ResultsThe foramen spinosum is located anterosuperior to the sphenoidal spine, whereas the chorda tympani courses caudal and medial to the sphenoidal spine and the Eustachian tube and parapharyngeal internal carotid artery (pICA) are at its posterior aspect. Two virtual vertical planes, at the anterior and posterior aspects of the sphenoidal spine, respectively, correspond to the posterior trunk of V3 and middle meningeal artery, and the stylopharyngeal aponeurosis. The average length of sphenoidal spine was 8.5 ± 2.43 mm, and the distance from distal apex of the sphenoidal spine to the foramen ovale, foramen spinosum, and pICA were 10.82 ± 0.83 mm, 6.42 ± 0.52 mm, and 5.02 ± 0.54 mm, respectively.ConclusionsThe sphenoidal spine is a meaningful landmark for endonasal approaches to the ITF. Measurements and conceptualization of vertical planes prior and posterior to the sphenoidal spine are beneficial to better appreciate the anatomic relationships in the ITF.
A revised electronic version of RUCAM for the diagnosis of DILI
Authors: Hayashi Paul H. , Lucena M. Isabel , Fontana Robert J. , Bjornsson Einar S. , Aithal Guruprasad P. , Barnhart Huiman , Gonzalez‐Jimenez Andres , Yang Qinghong , Gu Jiezhun , Andrade Raul J. , Hoofnagle Jay H. 
Published: January 2022

Abstract

Background and Aims
Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug‐Induced Liver Injury Network (DILIN) and the Spanish DILI Registry, published literature, and iterative computer modeling.

Approach and Results
RUCAM criteria were updated, clarified, and computerized. We removed criteria 3 (risk factors) for lack of added value and criteria 4 because we felt it more useful to assess each drug separately. Criteria 6 (drug‐specific risk) was anchored to LiverTox likelihood scores. Iterative testing in subsets of 50–100 single‐agent, nonherbal cases from both registries was done to optimize performance. We used classification tree analysis to establish diagnostic cutoffs for this revised electronic causality assessment method (RECAM) and compared RECAM with RUCAM for correlation with expert opinion diagnostic categories in 194 DILI cases (98 DILIN, 96 Spanish DILI). Area under receiver operator curves for identifying at least probable DILI were the same at 0.89 for RECAM and RUCAM. However, RECAM diagnostic categories have better observed overall agreement with expert opinion (0.62 vs. 0.56 weighted kappa, p = 0.14), and had better sensitivity to detect extreme diagnostic categories (73 vs. 54 for highly likely or high probable, p = 0.02; 65 vs. 48 for unlikely/excluded, p = 0.08) than RUCAM diagnostic categories.

Conclusions
RECAM is an evidence‐based update that is at least as capable as RUCAM in diagnosing DILI compared with expert opinion but is better than RUCAM at the diagnostic extremes. RECAM’s increased objectivity and clarity will improve precision, reliability, and standardization of DILI diagnosis, but further refinement and validation in other cohorts are needed.
A sufficient condition for a quandle to be Latin
Authors: Lages António , Lopes Pedro , Vojtěchovský Petr 
Published: January 2022

AbstractA quandle is an algebraic structure satisfying three axioms: idempotency, right‐invertibility, and right self‐distributivity. In quandles, right translations are permutations. The profile of a quandle is the list of cycle structures, one per right translation in the quandle. In this note we prove that if, for each cycle structure in the profile of a quandle, no two cycle lengths are equal, then the quandle is latin—this is the sufficient condition mentioned in the title.
LINC00152 acts as a competing endogenous RNA of HMGA1 to promote the growth of gastric cancer cells
Authors: Chen Jiayi , Zheng Qingfang , Liu Fang , Jin Han , Wu Xiaoyue , Xi Yang 
Published: January 2022

AbstractBackgroundLong noncoding RNAs (lncRNAs) play important roles in almost every stage of cancer development. Given the competing endogenous RNA (ceRNA) hypothesis for the regulation of gene expression, we investigated the role of LINC00152 as a ceRNA in gastric cancer (GC) cells.MethodsGastric cancer cell lines were used in this study. Mimics of miRNAs and siRNA were used to evaluate the interaction between LINC00152 and HMGA1. The quantitative real‐time polymerase chain reaction was performed for analyzing gene expression at the transcriptional level. Flow cytometry assay of cell cycle and western blot analysis of related protein expression levels were performed. Online databases such as TCGA and TIMER were used to determine the possibility of HMGA1 and LINC00152 as GC markers and their role in immune infiltration.ResultsTreating GC cell lines with LINC00152 siRNAs downregulated the expression of HMGA1. The cell cycle was arrested in the S phase following a reduction in LINC00152 or HMGA1 expression, whereas the expression of the cell cycle inhibitor P27 increased. In this study, we showed that acting as a ceRNA of HMGA1, LINC00152 has the same function as HMGA1, considering that it could control the cell cycle and promote GC cell proliferation. The TCGA database showed that LINC00152 might be used as a diagnostic marker for GC.ConclusionsThese findings provide mechanistic insights into the role of LINC00152 as a ceRNA to regulate HMGA1 expression in GC cells, where it can promote the proliferation of the GC cells by regulating the expression of the P27.
Light‐activated oxidize‐mimicking nanozyme for inhibition of pathogenic Escherichia coli
Authors: Loukanov Alexandre , Kuribara Ayano , Nikolova Svetla , Saito Masakazu 
Published: January 2022

AbstractHere we demonstrate the nanozyme properties of histidine‐containing carbon nanodots as externally tunable antibacterial agents through irradiation with visible (VIS) light. The correlative (light and electron) microscopic analysis of treated Escherichia coli O157:H7 revealed that the positive charged carbon nanoparticles might readily adsorb at slightly acid pH on the negative charged cellular envelope of bacteria, and thus, inhibit their growth with over 80% efficiency under illumination with VIS light. The reason was that under VIS irradiation in the range 400–500 nm the adsorbed nanoparticles behaved as effective oxidase‐mimicking enzymes and generated reactive oxygen species on the labeled cells. Thus, the light‐activated artificial nanozyme caused serious physical damaging of bacterial envelope, which was leading to irreversible cellular inhibition. The outcomes of this study are likely to broaden the scope of designed photoactive carbon nanozymes as powerful antibacterial agents against the emergence of antibiotic and multidrug‐resistant strains, as well as proposing of new strategies for infection control.
Efficacious bioremediation of heavy metals and radionuclides from wastewater employing aquatic macro‐ and microphytes
Authors: Das Swati , Das Sovik , Ghangrekar Makarand M. 
Published: January 2022

AbstractCytotoxic, mutagenic, and carcinogenic contaminants, such as heavy metals and radionuclides, have become an alarming environmental concern globally, especially for developed and developing nations. Moreover, inefficient prevalent wastewater treatment technologies combined with increased industrial activity and modernization has led to increase in the concentration of toxic metals and radioactive components in the natural water bodies. However, for the improvement of ecosystem of rivers, lakes, and other water sources different physicochemical methods such as membrane filtration, reverse osmosis, activated carbon adsorption, electrocoagulation, and other electrochemical treatment are employed, which are uneconomical and insufficient for the complete abatement of these emerging pollutants. Therefore, the application of bioremediation employing aquatic macrophytes and microphytes have gained considerable importance owing to the benefits of cost‐effectiveness, eco‐friendly, and higher energy efficiency. Thus, the present review aims to enlighten the readers on the potential application of algae, cyanobacteria, plant, and other aquatic micro‐ and macrophytes for the elimination of carcinogenic metals and radioactive isotopes from wastewater. Additionally, the use of transgenic plants, genetically modified species, algal–bacterial symbiosis for the enhancement of removal efficiency of mutagenic contaminants are also highlighted. Furthermore, species selection based on robustness, mechanism of different pathways for heavy metal and radionuclide detoxification are elucidated in this review article.
Development of core‐satellite‐shell structured MNP@Au@MIL‐100(Fe) substrates for surface‐enhanced Raman spectroscopy and their applications in trace level determination of malachite green in prawn
Authors: Pu Hongbin , Zhu Haofan , Xu Fang , Sun Da‐Wen 
Published: January 2022

AbstractMalachite green (MG) abuse in aquaculture has caused food safety issues and surface‐enhanced Raman scattering (SERS) can be utilized to monitor MG residues in aquatic products. However, the sensitivity and accuracy of SERS detection are limited by food matrix interference. Therefore, in this study, SERS active MNP@Au@MIL‐100(Fe) substrates were developed by utilizing magnetic nanoparticle (MNP) as the core, which was evenly decorated with Au nanoparticles (AuNPs), and then coated with metal–organic frameworks (MOFs) shell of MIL‐100(Fe), which acted as a filter to only allow molecules with appropriate sizes to approach the inner AuNPs, thus avoiding food matrix interference and improving the identification ability to analytes. Experiments in detecting MG residues in prawns was realized with the limit of detection (LOD) of 1.32 × 10−10 M, showing great potential for its use as a reliable SERS substrate for monitoring food contaminants.
Qualitative and quantitative analysis of Alpiniae Oxyphyllae Fructus by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry
Authors: Zhang Yu , Dong Lei , Zhang Qingyu , Han Jing , Sui Wenwen , Wei Ziyun , Zhang Zan , Tong Yichen , Wang Sijie , Han Fei 
Published: January 2022

AbstractAlpiniae Oxyphyllae Fructus, as a homology of medicine and food, has been widely used in China for thousands of years. However, the existing qualitative and quantitative methods are difficult to evaluate the quality of Alpiniae Oxyphyllae Fructus samples from multiple sources. In this paper, an high‐performance liquid chromatography fingerprint was established for assessing the quality of Alpiniae Oxyphyllae Fructus from different areas. Then, high‐performance liquid chromatography was coupled to Fourier transform‐ion cyclotron resonance mass spectrometry for characterization of the chemical compositions in Alpiniae Oxyphyllae Fructus. In fingerprint analysis, 54 common peaks were confirmed and six chromatographic peaks of them were identified. The similarity of 14 samples from different areas was between 0.990 and 1.000. Moreover, a total of 30 chemical components were characterized by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry method, six compounds of which were decisively identified. Finally, the content of nootkatone was determined by high‐performance liquid chromatography. In conclusion, the methods used in this study are efficient for qualitative and quantitative analysis of Alpiniae Oxyphyllae Fructus. Also, these methods can be used to control the quality of other traditional Chinese medicines.
Controllable Design and Preparation of Hydroxyl‐Terminated Solution‐Polymerized Styrene Butadiene for Polyurethane Elastomers with High‐Damping Properties
Authors: Zhao Yongkai , Shou Tao , Fu Siwei , Qin Xuan , Hu Shikai , Zhao Xiuying , Zhang Liqun 
Published: January 2022

AbstractVibration and noise are ubiquitous in social life, which severely damage machinery and adversely affect human health. Thus, the development of materials with high‐damping performance is of great importance. Rubbers are typically used as damping materials because of their unique viscoelasticity. However, they do not satisfy the requirements of different applications with various working conditions. In this study, the advantages of the high loss factor of styrene butadiene rubber (SBR) are combined with the strong designability of polyurethane. Hydroxyl‐terminated solution‐polymerized styrene butadiene rubbers (HTSSBRs) with different structures are prepared using anionic polymerization. HTSSBRs are then used as the soft segment during the synthesis of temperature‐tunable high‐damping performance polyurethanes (HTSSBR‐polyurethanes (PUs)). The prepared HTSSBR‐PUs with different structures exhibit excellent loss performance, a maximum loss factor (tanδmax) of above 1.60, and an effective damping performance over a wide temperature range compared to traditional SBR and polyurethane. Therefore, this work offers an effective method for the design of damping materials with adjustable properties.