bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Rural Tourism and Environmental Influencing Factors Based on Analytic Hierarchy Model
Authors: Guo Na 
Published: March 2022

This research focuses on the analytic hierarchy model in the decision-making system that has a more complex structure and maintains the stability of the system, models the application process with the complexity and diversity of the rural economy, collects sample data with the help of different types of rural tourism questionnaire surveys, and integrates the data of rural tourism and other tourism into the model. The following are obtained: (1) During the level analysis, each phenotype track uses RRM,

C
1
=
0.26

,

C
2
=
0.223

,

C
3
=
0.52

,

C
4
=
0.25

,

C
5
=
0.833

,

C
6
=
0.442

,

C
7
=
0.75

,

C
8
=
0.127

,

C
9
=
0.876

,

C
10
=
0.792

,

C
11
=
0.049

,

C
12
=
0.16

,

C
13
=
0.166

, and

C
14
=
0.049

. The problems of the complex structure of the evaluation can be divided into simple analysis modules, and each module is analyzed at a level. The phenotypic trajectory of each individual is divided into target layer, standard layer, and scheme layer. (2) Arrangement and decision modeling were performed according to one or several indicators of different factors. In the hierarchical random regression model,

APC
=
0.214

,

UPUA
=
0.042

,

TO
=
0.081

,

YPUA
=
0.082

,

PCP
=
0.068

, and

APS
=
0.067

. The characteristic quantity analysis of different environments can be carried out, and the amplitude error and frequency error obtained are relatively small.

IAND
=
0.115

,

AVA
=
0.198

,

RD
=
0.119

,

PI
=
0.041

,

PCCL
=
0.142

,

IOC
=
0.201

, and

DSTC
=
0.069

. The comparison shows that the hierarchical analysis model is better than the hierarchical random regression model. (3) High-efficiency hybrid model correlation acceleration is the worst model. The experimental data are

APC
=
0.147

,

UPUA
=
0.029

,

TO
=
0.055

,

YPUA
=
0.06

,

PCP
=
0.047

,

APS
=
0.046

,

IAND
=
0.079

,

AVA
=
0.136

,

RD
=
0.082

,

PI
=
0.028

,

PCCL
=
0.098

,

IOC
=
0.139

, and

DSTC
=
0.048

. (4) The predicted 2020 data and the actual data have small errors. The data obtained by the AHP model is

GDP
=
1262.1

,

finance
=
185.09

,

budget
=
68

,

tax
=
51.92

,

fund

budget
=
69.23

,

transfer

income
=
40.14

,

debt

income
=
7.73

,

disposable

financial

power
=
177.37

,

fiscal

expenditure
=
191.26

,

public

budget
=
88.68

,

government

expenditure
=
71.39

,

transfer

expenditure
=
23.46

,

debt

expenditure
=
7.73

, and

last

year

balance
=
2.39

.
Discussion on Protein Metabolism and Requirement of Aerobics Athletes during Training Based on Multisensor Data Fusion
Authors: Gong Hua , Chen Shuang , Yu Shuo , Liu Dong , Li Xin , Shan Zeliang , Kong Fan , Yan Zhi , Han Feng 
Published: March 2022

Competitive aerobics has emerged as a highly competitive sport beyond its own physical limit. Modern competitive aerobics competition is very fierce; athletes cannot only rely on a specific competitive skill to achieve good results. Protein is the physical basis of life activity. The life activity of human body is closely related to protein, and protein is closely related to human exercise ability. This article aims to study protein metabolism and demand of aerobics athletes during training based on multisensor data fusion. A total of 26 female aerobics athletes were randomly divided into two groups: exercise group and exercise + nutrition group. According to the characteristics of human motion, a comprehensive measurement acquisition sensor system for collecting human motion information is designed and implemented, and the system is used to monitor the subject’s protein condition in real time. The subjects took protein nutrient solution before breakfast every day. The dynamic recognition algorithm designed in this paper also has shortcomings, and the monitoring protein method based on gait and other signs is not completely correct. The experiment lasted for 7 weeks. The results showed that the level of serum transferrin receptor decreased significantly in the quiet + nutrition group for 4 weeks, which was significantly different from that at 0 and 3 weeks in the same group (

P

< 0.01) and was significantly different from that in the same group at 7 weeks (

P

< 0.05). In the exercise group, the level of serum transferrin receptor increased significantly at 5 weeks, compared with the same group at 0 and 3 weeks (

P

< 0.05).
Effects of Dietary Chlorogenic Acid Supplementation Derived from Lonicera macranthoides Hand-Mazz on Growth Performance, Free Amino Acid Profile, and Muscle Protein Synthesis in a Finishing Pig Model
Authors: Wang Wenlong , Li Fengna , Duan Yehui , Guo Qiuping , Zhang Lingyu , Yang Yuhuan , Yin Yunju , Han Mengmeng , Gong Saiming , Li Jianzhong , He Shanping , Yin Yulong 
Published: March 2022

Chlorogenic acid (CGA), as one of the richest polyphenol compounds in nature, has broad applications in many fields due to its various biological properties. However, initial data on the effects of dietary CGA on protein synthesis and related basal metabolic activity has rarely been reported. The current study is aimed at (1) determining whether dietary CGA supplementation improves the growth performance and carcass traits, (2) assessing whether dietary CGA alters the free amino acid profile, and (3) verifying whether dietary CGA promotes muscle protein synthesis in finishing pigs. Thirty-two (Large × White × Landrace) finishing barrows with an average initial body weight of

71.89
±
0.92

kg were randomly allotted to 4 groups and fed diets supplemented with 0, 0.02%, 0.04%, and 0.08% CGA, respectively. The results indicated that, compared with the control group, dietary supplementation with 0.04% CGA slightly stimulated the growth performance of pigs, whereas no significant correlation was noted between the dietary CGA levels and animal growth (

P
>
0.05

). Furthermore, the carcass traits of pigs were improved by 0.04% dietary CGA (

P
<
0.01

). In addition, dietary CGA significantly improved the serum free amino acid profiles of pigs (

P
<
0.01

), while 0.04% dietary CGA promoted more amino acids to translocate to skeletal muscles (

P
<
0.05

). The relative mRNA expression levels of SNAT2 in both longissimus dorsi (LD) and biceps femoris (BF) muscles were augmented in the 0.02% and 0.04% groups (

P
<
0.05

), and the LAT1 mRNA expression in the BF muscle was elevated in the 0.02% group (

P
<
0.05

). We also found that dietary CGA supplementation at the levels of 0.04% or 0.08% promoted the expression of p-Akt and activated the mTOR-S6K1-4EBP1 axis in the LD muscle (

P
<
0.05

). Besides, the MAFbx mRNA abundance in the 0.02% and 0.04% groups was significantly lower (

P
<
0.05

). Our results revealed that dietary supplementation with CGA of 0.04% improved the free amino acid profile and enhanced muscle protein biosynthesis in the LD muscle in finishing pigs.
Debates on the Nature of Blood and the Forging of Social Models in Early Modern Spain (1630s)
Authors: Ortega-del-Cerro Pablo , Hernández-Franco Juan 
Published: March 2022

Abstract
During the early modern period, blood was not only the red fluid that circulates within the body, but also an important cultural and social element. It was a symbol that synthesized and represented the most relevant social principles: individuals, families, and groups were defined according to the alleged nature of their blood, and, thus, it was an important matrix through which society was built and imagined. However, there were many ways to think about blood, each of which reflected a different social model. In this article, we study different concepts of blood and seek to understand their symbolic value. We aim to dissect and analyze their meanings in order to reconstruct the implicit models of society which they embodied. We focus on three Castilian treatises that deal with the issue of purity-of-blood, written by Fernando de Valdés, Gerónimo de la Cruz, and Bartolomé Jiménez de Patón in the 1630s – a decade of resurgent Anti-Judaism and racist attitudes in Castile. They represent different currents of opinion about purity-of-blood statutes – essentially, those wishing to abolish, reform, and preserve this system of social segregation – and they allow us to examine the characterization of blood traits, the construction of social principles, and the forging of ideal societies.
Hobbes Reenvisions Hebraic and Christian History
Authors: Nyquist Mary 
Published: March 2022

Abstract
In this essay, I examine Hobbes’s interpretation of Scriptural passages that figure prominently in contemporaneous political debates. Hobbes’s interpretative practices affirm his major systematic aims but also contribute to his inventive reenvisioning of Hebraic and Christian political history. The privileged position Hobbes gives Hebraic forms of rule together with his treatment of I Samuel 8 are motivated, in part, by a need to counter Aristotle’s influence on an exegetical tradition that opposes monarchy-as-tyranny in connection with this central, much-debated text. Hobbes conjoins his counter-revolutionary interpretation of 1 Samuel 8 with specific passages in the Christian New Testament that permit him to insert Jesus as “king of the Jews” into a startlingly unique conception of Hebraic and Christian history. This revisionary history and eschatology support Hobbes’s theorization of absolute sovereignty and undercut fantastical beliefs in an immaterial world.
Grammatical Propositions
Authors: Schmitz Barbara 
Published: March 2022

SummaryFirst of all, this paper aims at a clarification of Wittgenstein’s conception of grammatical propositions. Their essential characteristics will be developed and some of the central questions concerning their status will be discussed: Should grammatical propositions be seen as arbitrary conventions? How do they work in practices? And how do they relate to natural facts? Later on, the two propositions “Every rod has a length” and “Sensations are private” will be discussed in more detail, for both fulfil three important features of grammatical propositions: They are not empirical descriptions, they are rules of a practice, and they are not knowledge-claims but express insights. Focussing on the grammar of pain language, it will be shown what kind of interdependency exists between grammar and natural facts. It will also turn out that some grammatical propositions are closely connected to our understanding of living a human form of life.
A systematic literature review and meta-analysis of the effect of psilocybin and methylenedioxymethamphetamine on mental, behavioural or developmental disorders
Authors: Kisely Steve , Connor Mark , Somogyi Andrew A , Siskind Dan 
Published: March 2022

Objectives: There is an increasing interest in combining psilocybin or methylenedioxymethamphetamine with psychological support in treating psychiatric disorders. Although there have been several recent systematic reviews, study and participant numbers have been limited, and the field is rapidly evolving with the publication of more studies. We therefore conducted a systematic review of PubMed, MEDLINE, PsycINFO, the Cochrane Central Register of Controlled Trials, Embase, and CINAHL for randomised controlled trials of methylenedioxymethamphetamine and psilocybin with either inactive or active controls. Methods: Outcomes were psychiatric symptoms measured by standardised, validated and internationally recognised instruments at least 2 weeks following drug administration, Quality was independently assessed using the Cochrane risk of bias assessment tool and Grading of Recommendations Assessment, Development and Evaluation framework. Results: There were eight studies on methylenedioxymethamphetamine and six on psilocybin. Diagnoses included post-traumatic stress disorder, long-standing/treatment-resistant depression, obsessive-compulsive disorder, social anxiety in adults with autism, and anxiety or depression in life-threatening disease. The most information and strongest association was for the change in methylenedioxymethamphetamine scores compared to active controls in post-traumatic stress disorder ( k = 4; standardised mean difference = −0.86; 95% confidence interval = [−1.23, −0.50]; p < 0.0001). There were also small benefits for social anxiety in adults with autism. Psilocybin was superior to wait-list but not niacin (active control) in life-threatening disease anxiety or depression. It was equally as effective as escitalopram in long-standing depression for the primary study outcome and superior for most of the secondary outcomes in analyses uncorrected for multiple comparisons. Both agents were well tolerated in supervised trials. Trial quality varied with only small proportions of potential participants included in the randomised phase. Overall certainty of evidence was low or very low using the Grading of Recommendations Assessment, Development and Evaluation framework. Conclusion: Methylenedioxymethamphetamine and psilocybin may show promise in highly selected populations when administered in closely supervised settings and with intensive support.
Sources of Instability in Nigeria’s Manufacturing Performance: 1981–2018
Authors: Onodje Michael Akpovbera , Onodje Patrick Onosode 
Published: March 2022

The article investigates factors that may be responsible for observed instability in Nigeria’s manufacturing sector performance. Based on growing concerns regarding early deindustrialisation observed for many developing countries, the study examines how a menu of fiscal and monetary policies can be applied to revitalise the Nigerian manufacturing sector. Consequently, we construct an index of manufacturing sector instability and examine how it responds to a mixture of fiscal and monetary policy variables. We use annual time series data from 1981–2018 and apply the ARDL bounds test technique. Our findings show that budget deficits induce instability in the performance of the Nigerian manufacturing sector, while government infrastructural investments stabilise it. The monetary policy instruments were found to have inconsistent short-run and long-run influences but mostly conform with theory. JEL Codes: F63, L20, L25, L60, O10, O14
Does the Running Variable Matter? A Second Look at Discontinuity Designs for Evaluating Regional Economic Development and Business Incentive Policies
Authors: Bondonio Daniele 
Published: March 2022

In recent years, a growing number of studies have applied regression discontinuity designs (RDDs) to the analysis of prominent regional economic development and business incentive policies. As a result, impact evaluations of these policy interventions are being increasingly commissioned under the assumption that local linear regressions have superior impact identification properties in the cases in which an eligibility boundary, geographical border or application cutoff is identifiable as a source of treatment assignment. This paper shows that in a number of frequently encountered cases, however, economic development and business incentive programs pose peculiar impact identification conditions in terms of violations of main assumptions for the validity of RDDs and of running variables that have little or no influence of the outcome variable. Under these circumstances, that bear generalizable relevance also for the analysis of other public programs at large, no adequate testing to support the internal validity of the applied discontinuity design is often performed in the literature and the use of local linear/polynomial regressions, or cross-border comparisons, becomes an inadequate choice. When these conditions apply, adopting instead other quasi-experimental methods to achieve an actual adequate treatment-control balance of the relevant baseline characteristic will often be a better approach. JEL classification; O1; R5; C23
Squamous cell histological transformation in a lung adenocarcinoma patient (hyper) progressing upon immunotherapy
Authors: Mariniello Annapaola , Righi Luisella , Morrone Antonio , Carnio Simona , Bironzo Paolo 
Published: March 2022

Introduction: In non-small cell lung cancer (NSCLC) histologic transformation upon immune checkpoint inhibitors (ICI) is rare. Case presentation: We described the case of a patient with early-stage lung adenocarcinoma who relapsed after surgery. At the time of relapse, he received chemo-radiotherapy, followed by consolidation immunotherapy. After 3 cycles the patient experienced disease hyperprogression for onset of a new lung mass, which resulted in squamous cell carcinoma. The preservation of an atypical mutation in the v-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene in both the primary adenocarcinoma and the new squamous carcinoma suggests histological transformation, likely ICI-related. Discussion: We reviewed similar cases in literature, highlighting common patterns and substantial differences. For a deeper insight into inherent biological mechanisms, re-biopsy in case of atypical ICI response should be encouraged.
Factors associated with intraoperative intravenous catheter extravasation in children
Authors: Mecoli Marc D , Ding Lili , Yang Gang , McSoley Joseph W , Doellman Darcy A , Rineair Sylvia A , Subramanyam Rajeev 
Published: March 2022

Summary This retrospective study aimed to determine the incidence of and factors associated with peripheral intravenous extravasation in paediatric patients in the intraoperative setting. We conducted a retrospective study of 56,777 patients who underwent general anaesthesia and had peripheral intravenous catheter placement at Cincinnati Children’s Hospital between 1 January 2015 and 1 January 2017. Data collected included age, American Society of Anesthesiologists Physical Status Classification, catheter site, number of cannulation attempts, ultrasound use for cannulation, surgery duration, and surgery class. Primary outcome was peripheral intravenous extravasation using an extravasation assessment tool. Some 64,814 peripheral venous catheters were placed in patients undergoing general anaesthesia. Significant extravasation was documented in 40 catheters with an estimated incidence of 1 in 1620 venous catheters (0.06%). Of those 40 catheters, 47.5% ( n = 19) were placed using ultrasound and 37.5% ( n = 15) required more than one cannulation attempt. In multivariable analysis, peripheral intravenous catheter extravasation was associated with American Society of Anesthesiologists Physical Status Classification (3, 4, 5) versus (1, 2) (odds ratio 2.42 (95% CI 1.08 to 5.41)), inpatient versus outpatient surgeries (odds ratio 2.99 (95% CI 1.31 to 6.81)), and intravenous catheters placed with ultrasound guidance (odds ratio 8.01 (95% CI 4.12 to 15.57)). Our study identified factors associated with intraoperative peripheral intravenous extravasation, and will help develop mitigation strategies to minimise harm to patients.
Sexually transmitted infections incidence in young Thai men who have sex with men and transgender women using HIV pre-exposure prophylaxis
Authors: Songtaweesin Wipaporn N , Pornpaisalsakul Krittaporn , Kawichai Surinda , Wacharachaisurapol Noppadol , Wongharn Prissana , Yodkitudomying Chatnapa , Panichnantakul Pantila , Theerawit Tuangtip , Pankam Tippawan , Puthanakit Thanyawee 
Published: March 2022

Background Sexually transmitted infections are a major public health issue worldwide. HIV pre-exposure prophylaxis (PrEP) use among youth may be associated with increased incidence of sexually transmitted infections (STIs). Objectives To measure the prevalence and incidence of STIs among young men who have sex with men (YMSM) and young transgender women (YTGW) using PrEP. Methods A prospective cohort of 15- to 19-year-old YMSM and YTGW with HIV risk defined as inconsistent condom use and/or multiple sex partners were enrolled. Participants were provided daily oral tenofovir disoproxil fumarate/emtricitabine. STI screening was done at baseline and month 6 for syphilis, urine, and anal swab nucleic acid amplification testing for C. trachomatis (CT) and N. gonorrheaoe (NG). Results From March 2018 to June 2019, 200 adolescents (147 MSM and 53 TGW) with a median (IQR) age of 18 years (17–19) were enrolled. STI prevalence was 22.5% (95% CI 16.7–28.3). STI incidence was 25.2 per 100 person–years (95% CI 14.7, 40.3). Factors associated with STI incidence were self-reported >2 sex partners in the past month (unadjusted rate ratio [uRR] 4.6, 95% CI 1.0, 20.6), and moderate PrEP adherence (uRR 7.3, 95% CI 1.6, 32.6). Conclusions STI incidence in YMSM and YTGW PrEP users was high at approximately one in five. Regular screening and treatment of STIs should be implemented in youth HIV prevention packages.
Evaluation of subclinical retinal microvascular changes in systemic lupus erythematosus patients using optical coherence tomography angiography and its relationship with disease activity
Authors: ERMURAT Selime , Koyuncu Kevser 
Published: March 2022

Objective This study aimed to investigate subclinical retinal microvascular changes with optical coherence tomography angiography (OCTA) in patients with systemic lupus erythematosus (SLE) and healthy controls (HCs), and to evaluate the relationship between OCTA findings and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). Materials and Methods In this study, 47 eyes of SLE and 41 eyes of healthy control (HC) were evaluated. The SLE patients were divided into two subgroups: low disease activity (LDA) (SLEDAI≤5) and high disease activity (HDA) (SLEDAI>6). The results of OCTA were compared between SLE patients and HCs as well as the SLE subgroups. The relationship between OCTA results and SLEDAI-2K was evaluated. Results There were no differences in foveal avascular zone (FAZ) areas between the SLE patients and HCs. Central foveal thickness (CFT) was lower in SLE patients ( p = .046). Superficial capillary plexus (SCP) vessel density (VD) in SLE patients was significantly lower only in the foveal area compared to that in HCs ( p = .006). Deep capillary plexus (DCP) VD in SLE patients was significantly lower in all areas except the temporal parafoveal area compared to that in the HCs. There was no statistically significant difference between SLE groups with LDA and HDA in FAZ or any of the other areas, including SCP and DCP. When the correlation between OCTA findings and SLEDAI-2K was examined, both SCP and DCP VD were found to be negatively correlated. conclusions It was observed that DCP VDs were affected in SLE patients with LDA, and SCP VDs were also affected in addition to DCP with HDA. This suggests that DCP may be the first capillary plexus to be comprised in SLE. VDs were negatively correlated with disease activity. It was concluded that OCTA can be a useful tool in assessing subclinical retinal microvascular pathology and disease activity in patients with SLE.