bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actions speak louder than words? The impact of subjective norms in the supply chain on green innovation
Authors: Shou Yongyi , Shan Xueshu , Dai Jing , Xu Dong , Che Wen 
Published: December 2022

PurposeAdopting the theory of planned behavior, this study attempts to investigate how subjective norms in the supply chain influence a firm's green innovation and how such influences are contingent upon the firm's internal and external factors (i.e. flexibility orientation and environmental dynamism). Two types of subjective norms are examined, i.e. injunctive norms (what supply chain partners say) and descriptive norms (what supply chain partners do).Design/methodology/approachUsing survey data of 178 Chinese small and medium-sized manufacturers, we employ hierarchical linear regression to test the proposed hypotheses.FindingsOur results indicate that both injunctive and descriptive norms are instrumental in stimulating firms to take actions on green innovation. Moreover, the flexibility orientation of a firm can strengthen the effect of descriptive norms. It is also observed that environmental dynamism weakens the efficacy of injunctive norms but strengthens that of descriptive norms on green innovation.Originality/valueThis study is among the first to apply the theory of planned behavior to explain the microfoundations of focal firm's green innovation and distinguish two types of subjective norms in the supply chain. In addition, it extends the theory of planned behavior by revealing internal and external contingent factors (i.e. flexibility orientation and environmental dynamism) of the relationship between subjective norms and firm behaviors.
Exploration of small and medium entities' actions on sustainability practices and their implications for a greener economy
Authors: Afolabi Hammed , Ram Ronita , Hussainey Khaled , Nandy Monomita , Lodh Suman 
Published: December 2022

PurposeThe authors explore the behaviour and perspectives of SMEs' owners towards a greener economy and its implications for net zero carbon emissions target.Design/methodology/approachThe authors draw on the mirroring concept and 26 semi-structured interviews with SMEs' owners and managers to provide insights and explore the misalignment between SMEs' actions and perceptions and the technical architecture (and requirements) of achieving net zero carbon emissions in the UK.FindingsThe authors find that SMEs lack trust and are sceptical about the government's net zero emissions agenda. The authors also find that lack of understanding and perceived benefits, and supply chain complexities (end-to-end emissions) are the key factors hindering SMEs interests in engaging with better carbon emissions management and environmental management system (EMS). Moreover, pressure from external stakeholders, particularly banks and customers, is a strong driver to draw SMEs more effectively with sustainability and environmental impact disclosure.Research limitations/implicationsThe sample is limited to 26 SMEs' owners operating in seven industries. Future research could explore the result in other industries. Further research could also investigate how the sustainability reports produced by SMEs are useful for different user groups' decision-making. This study reinforces the social constructionist approach to advance our understanding of SMEs' actions towards carbon emission management and EMS.Practical implicationsThis study shows how government policies and SMEs' interests can be aligned to achieve the net zero carbon emissions target.Originality/valueThis is the first study to examine the perceptions and behaviour of SMEs towards the ongoing pursuit of a greener economy in the UK, including the key factors driving their actions and reasoning.
Corporate social responsibility communication of male luxury fashion brands: analysis on Instagram, Facebook and TikTok
Authors: Castillo-Abdul Bárbara , Ortega Fernandez Eglée , Romero-Rodriguez Luis M. 
Published: December 2022

PurposeThis study aims to analyze the content on corporate social responsibility (CSR) of Gucci, Prada and Ermenegildo Zegna on the social networks Instagram, Facebook and TikTok in order to examine the focus of the publications of these luxury brands, what type of content is more frequent and which ones generate more interaction and engagement.Design/methodology/approachAn interpretive content analysis of a sample of 92 posts on CSR published between December 2021 and June 2022 is used. For this purpose, an analysis sheet validated through theoretical constructs and pilot testing is used.FindingsMost of the social responsibility content of the fashion brands analyzed is linked to the use of sustainable materials, the protection of natural spaces and, in the particular case of Prada, the protection of the oceans. The posts that achieve the highest interactions are videos and photo reels. Although the strategies that significantly increase brands' reach on social networks are collaborations and joint posts with other fashion brands, as is the case of Gucci with NorthFace and Prada with Adidas. Also, one of the main findings of this research has been to identify that brands may be using TikTok – perhaps experimentally – to reach stakeholders in Asian countries, especially China, where other platforms such as Instagram or Facebook may have a more limited reach.Originality/valueThis research shows that the social responsibility activities of luxury fashion brands leverage the content marketing strategy in social networks. It also demonstrates the importance of the Asian market (mainly Chinese) in the outreach strategies of brands, as is the case of Gucci and Prada, which bet on CSR activities for the protection of the Asian tiger in the framework of the year of the tiger in the Chinese horoscope, as well as the publication of certain content on TikTok.
Yogliptin monotherapy in type 2 diabetes: A 12‐week randomized, double‐blind, placebo‐controlled phase II study
Authors: Wang Xin , Wang Ying , Yong Xiaolan , Wu Bojun , Sun Zilin , Lou Ning , Wen Qing , Zhang Yufang , Li Shiyun , Li Jiarui , He Yan , Cheng Jinluo , Zhong Xiangdong , Shen Jing , Yang Wenying 
Published: December 2022

AbstractBackgroundThe new xanthine dipeptidyl peptidase‐4 inhibitor yogliptin has exhibited excellent hypoglycemic activity in experimental disease models. The present work aimed to assess the efficacy of yogliptin as a monotherapy in individuals with type 2 diabetes mellitus (T2DM).MethodsA 12‐week, double‐blind, placebo‐controlled phase II study was performed. T2DM patients (new diagnosis or inadequately controlled) were randomly divided into groups (1:1:1:1) and administered either a placebo or weekly doses of 200, 300, or 400 mg yogliptin, respectively. The primary efficacy end point in this analysis was hemoglobin A1c (HbA1c) change at 12 weeks relative to baseline. Relevant secondary outcomes were also examined, including fasting plasma glucose (FPG), 2 h‐postprandial plasma glucose (PPG), body weight, and the rate of individuals who achieved the treatment goal of HbA1c ≤ 7% at 12 weeks from baseline.ResultsA total of 81 cases who received either the placebo (20 cases) or 200 (20 cases), 300 (20 cases), or 400 (21 cases) mg yogliptin were examined in the full analysis set. At 12 weeks, changes in HbA1c levels from baseline were 0.17 (−0.22, 0.57) in the placebo group, and −0.75 (−1.15, −0.35), −0.52 (−0.93, −0.11) and −1.02 (−1.41, −0.64) (mean % [95% confidence interval], p < .001 vs. placebo) in the 200, 300, and 400 mg yogliptin groups, respectively. From week four, significant improvements in secondary efficacy outcomes among patients administered the yogliptin monotherapy were observed. FPG showed markedly more pronounced reduction after treatment with yogliptin at 200, 300, and 400 mg in comparison with placebo patients at 4, 8, and 12 weeks. At 12 weeks, goal attainment (HbA1c ≤ 7%) was reached in 0%, 20.00%, 15.80%, and 33.33% of the placebo and three Yogliptin dosage groups, respectively. Adverse events were comparable in all groups.ConclusionsThis study demonstrated that yogliptin controlled glycemia in Chinese T2DM cases, with a great safety profile. The current findings supported that any of the three doses of yogliptin, administered once a week, could be used for phase III clinical studies.
Experts in the Boardroom: Director Connections in the Mutual Fund Industry*
Authors: Calluzzo Paul 
Published: December 2022

ABSTRACTThis study examines boardroom connections that form when corporate executives sit on mutual fund boards. These connections have the potential to facilitate information flow that informs fund investment decisions. I find that fund trades in the executive's firm anticipate future earnings news and stock returns during the period that the fund and firm are connected. The evidence is consistent with a broad scope of information being transferred through the connections, implying the potential for these connections to have an economically significant impact. For example, trades in the executive's firm predict returns both inside and outside of the earnings announcement period, and trades in stocks in the same sector as the executive's firm also predict returns. This study highlights the potential for the role of fund directors to extend beyond their formal monitoring responsibilities and act as conduits of information.
Combination treatment with varenicline and naltrexone reduces World Health Organization risk drinking levels
Authors: Nieto Steven J. , Enders Craig K. , Witkiewitz Katie , O'Malley Stephanie S. , Ray Lara A. 
Published: December 2022

AbstractBackgroundThe U.S. Food and Drug Administration identifies abstinence and the absence of heavy drinking days as outcomes for pharmacotherapy trials for alcohol use disorder (AUD). However, many individuals with AUD struggle to achieve these outcomes, which may discourage them from seeking treatment. World Health Organization (WHO) risk drinking levels have garnered attention in the alcohol field as potential non‐abstinent outcomes for AUD medication trials. Further, testing combination pharmacotherapy for AUD represents an important direction in the field, particularly using medications such as naltrexone and varenicline, which are approved for treating AUD and smoking, respectively. The objective of the current study was to test the utility of the WHO risk drinking levels as a drinking outcome in a randomized clinical trial of combined varenicline and naltrexone for smoking cessation and drinking reduction. These analyses provide additional tests of the efficacy of this combination treatment.MethodsThe current study is a secondary analysis of a phase 2, randomized, double‐blind clinical trial, wherein participants (N = 165) who were daily smokers and heavy drinkers were randomly assigned to receive either 2 mg/day of varenicline plus 50 mg/day of naltrexone or 2 mg/day of varenicline plus placebo for 12 weeks. Medication effects on 1‐ and 2‐level reductions in WHO risk drinking levels were assessed at 4, 8, and 12 weeks into the active medication period.ResultsIn logistic growth curve models individuals receiving the combined treatment had greater reductions in WHO risk drinking levels than individuals taking varenicline alone when assessed at 4 weeks into the active medication period. Among individuals who were WHO high and very high risk drinkers at baseline, the largest effect sizes favoring combination treatment were at Week 4 for the WHO 2‐level reduction outcome (Cohen's h = 0.202) and Week 12 for the WHO 1‐level reduction outcome (Cohen's h = 0.244), although these effects did not reach statistical significance.ConclusionsThese findings provide evidence that combined varenicline plus naltrexone treatment is effective at reducing WHO risk drinking levels, particularly among individuals who smoke cigarettes daily and drink heavily. These results add to a growing body of literature validating reductions in WHO risk drinking levels as outcomes of alcohol medication trials.
Selling Rural Palestine: Land Devaluation, Ethical Investment, and the Limits of Human Rights
Authors: Kohlbry Paul 
Published: December 2022

AbstractThis article is a study of the causes and consequences of making Palestinian land into an ethical investment. It builds on fieldwork in villages north of Ramallah where a Palestinian real estate company purchased devalued agricultural lands and offered them to Palestinian buyers as an ethical investment. It argues that through private titling, planning, and infrastructure, this company secured land for potential investors and produced an imaginary of rural areas as empty and unowned. It created enclaves that protect the rights of new owners but undermine the possibilities for collective land defence, and it pioneered a model of development that will transform the use and control of village land across the West Bank. Rather than an example of a company that uses human rights to cover up illegality, this case illuminates the limits of human rights for critiquing capital and settler colonialism and for understanding the forces that are reshaping rural Palestine.
Hypoxic stress accelerates the propagation of pathological alpha‐synuclein and degeneration of dopaminergic neurons
Authors: Guo Mengyuan , Liu Weijin , Luo Hanjiang , Shao Qianqian , Li Yuning , Gu Yakun , Guan Yuying , Ma Wei , Chen Min , Yang Hui , Ji Xunming , Liu Jia 
Published: December 2022

AbstractAimsThe etiology of Parkinson's disease (PD) is complex and the mechanism is unclear. It has become a top priority to find common factors that induce and affect PD pathology. We explored the key role of hypoxia in promoting the pathological propagation of α‐synuclein (α‐syn) and the progression of PD.MethodsWe performed PD modeling by conducting intracranial stereotaxic surgery in the unilateral striatum of mice. We then measured protein aggregation in vitro. The rotarod and pole tests were employed next to measure the damage of the phenotype. Pathological deposition and autophagy were also observed by immunofluorescence staining and protein levels measured by western blotting.ResultsWe demonstrated that short‐term hypoxia activated phosphorylated (p)‐α‐syn in mice. We confirmed that p‐α‐syn was more readily formed aggregates than α‐syn in vitro. Furthermore, we found that hypoxia promoted the activation and propagation of endogenous α‐syn, contributing to the earlier degeneration of dopaminergic neurons in the substantia nigra and the deposition of p‐α‐syn in our animal model. Finally, autophagy inhibition contributed to the above pathologies.ConclusionHypoxia was shown to accelerate the pathological progression and damage phenotype in PD model mice. The results provided a promising research target for determining common interventions for PD in the future.
Use of behavioural change taxonomies in systematic reviews and meta‐analyses regarding obesity management
Authors: Okonya Ochije , Siddiqui Bilal , George David , Fugate Colony , Hartwell Micah , Vassar Matt 
Published: December 2022

SummaryWe investigated the prevalence of behavioural change taxonomies in systematic reviews and meta‐analyses related to obesity management. In addition, we analysed the funding sources, author conflicts of interest statements, risk of bias, and favorability of the results in such studies to determine if there was a relationship between methodological quality and taxonomy use. We searched several databases including MEDLINE, Epistemonikos, Cochrane EDSR, Pubmed and Embase for systematic reviews and meta‐analyses regarding the behavioural treatment of obesity. Screening and data extraction was performed in a masked, duplicate fashion. We performed statistical analyses to determine any significant association between use of taxonomy and study characteristics. Fifteen (of 186; 8.06%) systematic reviews used a taxonomy—nine used the BCTTv1, three used OXFAB, two used the CALO‐RE and one used “Taxonomy of choice architecture techniques.” Most interventions that referenced a taxonomy were self‐mediated (6/60, 10%). Behavioural change taxonomies were mentioned in 10 (of 87, 11.49%) studies with a public funding source. Of the studies with favourable results, 14 studies (of 181, 7.73%) referred to a taxonomy. We found no statistically significant relationships between use of taxonomy and study characteristics. We found that systematic reviews regarding the management of obesity rarely mention a behavioural change taxonomy. Given the global burden of obesity, it is crucial that behavioural change techniques are reproducible and translatable. We recommend that researchers look further into how taxonomies affect the quality and reproducibility of behavioural interventions in an effort to improve patient outcomes.
Interdisciplinarity in Cognitive Science: A Document Similarity Analysis
Authors: Alasehir Oguzhan , Acarturk Cengiz 
Published: December 2022

AbstractCognitive science was established as an interdisciplinary domain of research in the 1970s. Since then, the domain has flourished, despite disputes concerning its interdisciplinarity. Multiple methods exist for the assessment of interdisciplinary research. The present study proposes a methodology for quantifying interdisciplinary aspects of research in cognitive science. We propose models for text similarity analysis that provide helpful information about the relationship between publications and their specific research fields, showing potential as a robust measure of interdisciplinarity. We designed and developed models utilizing the Doc2Vec method for analyzing cognitive science and related fields. Our findings reveal that cognitive science collaborates closely with most constituent disciplines. For instance, we found a balanced engagement between several constituent fields—including psychology, philosophy, linguistics, and computer science—that contribute significantly to cognitive science. On the other hand, anthropology and neuroscience have made limited contributions. In our analysis, we find that the scholarly domain of cognitive science has been exhibiting overt interdisciplinary for the past several decades.
Cognitive Science of Augmented Intelligence
Authors: Dubova Marina , Galesic Mirta , Goldstone Robert L. 
Published: December 2022

AbstractCognitive science has been traditionally organized around the individual as the basic unit of cognition. Despite developments in areas such as communication, human–machine interaction, group behavior, and community organization, the individual‐centric approach heavily dominates both cognitive research and its application. A promising direction for cognitive science is the study of augmented intelligence, or the way social and technological systems interact with and extend individual cognition. The cognitive science of augmented intelligence holds promise in helping society tackle major real‐world challenges that can only be discovered and solved by teams made of individuals and machines with complementary skills who can productively collaborate with each other.
Pharmacokinetics, safety and tolerability of valbenazine in Korean CYP2D6 normal and intermediate metabolizers
Authors: Chung Woo Kyung , Hwang Inyoung , Kim Byungwook , Jung Jihyun , Yu Kyung‐Sang , Jang In‐Jin , Oh Jaeseong 
Published: December 2022

AbstractValbenazine is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved for tardive dyskinesia treatment by the US Food and Drug Administration; its major active metabolite (NBI‐98782) is a 45‐fold more potent inhibitor of VMAT2 than the parent drug. This study aimed to evaluate the pharmacokinetics (PKs), safety, and tolerability and the effect of cytochrome P450 2D6 (CYP2D6) genotypes to the PKs after the administration of valbenazine in Korean participants. A randomized, double‐blind, placebo‐controlled, single‐ and multiple‐dose study was conducted in healthy Korean male participants. The single‐dose study was conducted for both 40 and 80 mg valbenazine and the multiple dose study was conducted for 40 mg. After a 1‐week washout, the 40 mg dose group participants received valbenazine 40 mg or placebo once daily for 8 days. Serial blood samples were collected up to 96 h postdose for PK analysis. The CYP2D6 genotypes of the participants were retrospectively analyzed. A total of 50 participants were randomized, and 43 and 20 participants completed the single‐ and multiple‐dose phases of the study, respectively. After single doses, the PK characteristics of valbenazine and its metabolites were similar between the 40 and 80 mg dose groups. After multiple doses, the mean accumulation ratios of valbenazine and NBI‐98782 were ~1.6 and 2.4, respectively. Plasma concentrations of valbenazine and NBI‐98782 were similar between CYP2D6 normal and intermediate metabolizers. Valbenazine was well‐tolerated in healthy Koreans, and its PK characteristics were similar to results previously reported in Americans.
La experiencia del diagnóstico y la atención en progenitores de niños diagnosticados con el Síndrome de Phelan‐McDermid: Un estudio cualitativo
Authors: García‐Bravo Cristina , Martínez‐Piédrola Rosa María , García‐Bravo Sara , Huertas‐Hoyas Elisabet , Pérez‐De‐Heredia‐Torres Marta , Palacios‐Ceña Domingo 
Published: December 2022

ResumenObjetivoEl Síndrome de Phelan‐McDermid (SPMD) es una enfermedad rara, infradiagnosticada y sin cura. El propósito de este estudio fue explorar la experiencia de los progenitores con niños diagnosticados con el Síndrome de Phelan‐McDermid, en relación con el proceso de diagnóstico, el tratamiento y la atención médica.MétodoSe realizó un estudio cualitativo descriptivo. Los participantes fueron reclutados mediante un muestreo intencional no probabilístico. En total, se incluyeron 32 progenitores con hijos con SPMD. Se utilizaron entrevistas en profundidad y notas de campo de los investigadores. Se realizó un análisis temático inductivo.ResultadosSe identificaron cinco temas: “El proceso diagnóstico”, se describe el proceso diagnóstico y la forma de comunicarlo a los progenitores; “El tratamiento y sus expectativas” describe las expectativas y esperanzas construidas sobre un futuro tratamiento; “Planificación familiar”, describe como los progenitores se enfrentan al consejo genético, para la planificación de tener más hijos tras el diagnóstico de SPMD; “El mundo de la discapacidad”, describe la entrada de los progenitores en el entorno de la dependencia y discapacidad tras el diagnóstico; “La economía familiar”, muestra las dificultades económicas debido al elevado coste de las terapias y los productos del cuidado diario.InterpretaciónNuestros resultados proporcionan una visión de cómo el diagnóstico y sus consecuencias son experimentados por los progenitores con niños con SPMD. Estos resultados pueden ser utilizados por los profesionales de la salud para ayudar y apoyar a los progenitores.