bluuebunny/crossref_metadata_2025_split huggingface dataset:
N400 event‐related brain potential and functional outcome in persons at clinical high risk for psychosis: A longitudinal study
Authors: Lepock Jennifer R. , Mizrahi Romina , Gerritsen Cory J. , Bagby R. Michael , Maheandiran Margaret , Ahmed Sarah , Korostil Michele , Kiang Michael 
Published: January 2022

BackgroundThe N400 event‐related brain potential (ERP) semantic priming effect is thought to reflect activation by meaningful stimuli of related concepts in semantic memory and has been found to be deficient in schizophrenia. We tested the hypothesis that, among individuals at clinical high risk (CHR) for psychosis, N400 semantic priming deficits predict worse symptomatic and functional outcomes after one year.MethodsWe measured N400 semantic priming at baseline in CHR patients (n = 47) and healthy control participants (n = 25) who viewed prime words each followed by a related or unrelated target word, at stimulus‐onset asynchronies (SOAs) of 300 or 750 ms. We measured patients' psychosis‐like symptoms with the Scale of Prodromal Symptoms (SOPS) Positive subscale, and academic/occupational and social functioning with the Global Functioning (GF):Role and Social scales, respectively, at baseline and one‐year follow‐up (n = 29).ResultsCHR patients exhibited less N400 semantic priming than controls across SOAs; planned contrasts indicated this difference was significant at the 750‐ms but not the 300‐ms SOA. In patients, reduced N400 semantic priming at the 750‐ms SOA was associated with lower GF:Social scores at follow‐up, and greater GF:Social decrements from baseline to follow‐up. Patients' N400 semantic priming was not associated with SOPS Positive or GF:Role scores at follow‐up, or change in these from baseline to follow‐up.ConclusionsIn CHR patients, reduced N400 semantic priming at baseline predicted worse social functioning after one year, and greater decline in social functioning over this period. Thus, the N400 may be a useful prognostic biomarker of real‐world functional outcome in CHR patients.
Safety and long‐term outcomes of early liver transplantation for pediatric methylmalonic acidemia patients
Authors: Lin Niang‐Cheng , Tsai Hsin‐Lin , Chen Cheng‐Yen , Yeh Yi‐Ting , Lei Hao‐Jan , Chou Shu‐Cheng , Chung Meng‐Hsuan , Yang Chia‐Feng , Niu Dau‐Ming , Loong Che‐Chuan , Hsia Cheng‐Yuan , Liu Chin‐Su 
Published: January 2022

AbstractBackgroundLT is a treatment option for MMA patients, but renal function impairment is one of the long‐term concerns. The aim of this study was to evaluate the outcomes of early LT in these patients.MethodsA total of 11 MMA mut‐type patients (including 10 mut0 cases and 1 mut‐case) who received LT in our institute were reviewed. Their metabolic profiles were compared between the pre/post‐transplant periods. Their immunosuppressant and renal function changes after transplantation were assessed.ResultsAfter a mean follow‐up of 97.5 ± 38.4 months, there were two deaths, and the actual survival rate was 81.8%. Their metabolic profiles had improved (mean blood ammonia level 366.8 ± 105.5 vs. 53.1 ± 17.4 μg/dl, p < .001; C3/C2 ratio 2.68 ± 0.87 vs. 0.73 ± 0.22, p = .003; mean urine MMA level 920.5 ± 376.6 vs. 196.2 ± 85.4, p = .067), and hospital stays were decreased (78.8 ± 74.5 vs. 7.4 ± 7.0 days/year, p = .009) after transplantation. The mean age at transplant was 1.81 ± 2.02 years old, and nine of these patients received LT before the age of 1.5 years old (early LT). Under prospective immunosuppressant dose reduction, three of these early LT patients discontinued the drug and were sustained for more than 5 years. Most of the patients had a preserved renal function, and no patient is currently on dialysis.ConclusionsIn addition to the improvement in the metabolic parameters, early LT in MMA patients may allow for a dose reduction of the immunosuppressant, and the patient's renal function could be preserved in the long term.
The multiple streams framework in a nondemocracy: The infeasibility of a national ban on live poultry sales in China
Authors: van den Dool Annemieke 
Published: January 2022

AbstractIn response to calls to apply the multiple streams framework to nondemocracies, this article adapts the framework to an authoritarian context and applies it to a case study of live poultry sales in food markets in China, a key issue in epidemic prevention. Using a dataset consisting of Chinese policy documents, Chinese news articles, World Health Organization data, and secondary literature, the study shows that despite the public health threat posed by live poultry sales and despite high‐level political support, a national‐level permanent ban has not been adopted because it is technically infeasible, financially inviable, and inconsistent with existing norms and values. The study suggests that—despite the country's top‐down governance style and lack of political pluralism—policy preferences expressed by members of the policy‐making elite are not necessarily adopted in authoritarian China. Future research should test the proposed hypotheses in other policy areas and other authoritarian contexts.
The right to a healthy environment: Reconceptualizing human rights in the face of climate change
Authors: Cima Elena 
Published: January 2022

AbstractThere is hardly any doubt that climate change threatens the enjoyment of a wide range of human rights. Yet, in the absence of a distinct right to a healthy environment, a victim of climate change impacts would have to rely on existing rights to bring a claim. However, not only are these avenues not always successful or even sufficient to effectively and adequately compensate the victims, but they appear especially problematic in the context of climate change. This article explores the implications of the recognition of a stand‐alone substantive right to a healthy environment in the context of climate change. In doing so, it argues that such a recognition could trigger a paradigm shift that would facilitate the reconceptualization of human rights law to better adapt to the negative impacts of climate change, in particular by incorporating key environmental law principles in the human rights system.
Transformation Model Based Regression with Dependently Truncated and Independently Censored Data
Authors: Qian Jing , Chiou Sy Han , Betensky Rebecca A. 
Published: January 2022

Abstract
Truncated survival data arise when the event time is observed only if it falls within a subject specific region. The conventional risk-set adjusted Kaplan–Meier estimator or Cox model can be used for estimation of the event time distribution or regression coefficient. However, the validity of these approaches relies on the assumption of quasi-independence between truncation and event times. One model that can be used for the estimation of the survival function under dependent truncation is a structural transformation model that relates a latent, quasi-independent truncation time to the observed dependent truncation time and the event time. The transformation model approach is appealing for its simple interpretation, computational simplicity and flexibility. In this paper, we extend the transformation model approach to the regression setting. We propose three methods based on this model, in addition to a piecewise transformation model that adds greater flexibility. We investigate the performance of the proposed models through simulation studies and apply them to a study on cognitive decline in Alzheimer's disease from the National Alzheimer's Coordinating Center. We have developed an R package, tranSurv, for implementation of our method.
Sinus lift technique and dental implants for rehabilitation for a Down syndrome patient with tomographic 3‐years follow‐up
Authors: Comparin Lizandra Lopes , Filho Ricardo Pasquini , Deliberador Tatiana , de Souza Gizelli , Tatim Thiago , Müller Paulo Roberto , Moreno Rubens 
Published: January 2022

AbstractDown Syndrome or trisomy 21 (T21) is a genetic condition caused by the presence of an extra chromosome in pair 21 and is related to a high prevalence of agenesis of permanent teeth and periodontal alterations that may be associated to the loss of permanent teeth at early ages. With the increase in life expectancy of people with T21 in the last decades, it is necessary to expand the knowledge to offer possibilities of treatment with dental implants, aiming to serve this aging population. Aims: The aim of this article is to report a surgical procedure of sinus lift to enable the installation of dental implants in the posterior region of the maxilla. Methods and results: A 50 year‐old patient with T21 was rehabilitated with implants, simultaneously with sinus lift surgery, by the lateral window technique, using xenogenous bone graft and fibrin‐rich plasma. After 1 year, the patient was rehabilitated with prosthetics on implants. Conclusion: The feasibility of this technique in patients with Down syndrome could be observed, after 3 years of follow up, with favorable clinical results.
Threats to Belonging and Health: Understanding the Impact of the COVID‐19 Pandemic using Decades of Research
Authors: Jaremka Lisa M. , Kane Heidi S. , Bell Ann V. 
Published: January 2022

AbstractThe COVID‐19 pandemic, an external stressor with multiple stressful sequelae, has fundamentally changed people's lives over multiple years. In this article, we first review research demonstrating that the pandemic has negatively impacted people's sense of belonging and health over time. Next, we draw upon decades of theoretical and empirical work demonstrating that threats to belonging and mental health problems are highly interrelated, with increases in the former driving increases in the latter. We then extend this discussion to physical health, drawing upon a wealth of theoretical and empirical work demonstrating that threats to belonging are a risk factor for longer term health problems and premature mortality. We also highlight potential mechanisms linking threats to belonging and health, with a focus on sleep and immune function. Throughout, we review how pre‐existing vulnerabilities may moderate these processes. We conclude with empirically supported recommendations for policymakers interested in addressing these issues.
Reviewer Acknowledgements for Business and Management Studies, Vol. 7, No. 4
Authors: Willianms Ellery 
Published: January 2022

Business and Management Studies (BMS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether BMS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 7, Number 4 Abdul-Kahar Adam, University of Education, Winneba, GhanaDalia Susniene, Kaunas University of Technology, LithuaniaIulia Cristina Muresan, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, RomaniaIza Gigauri, St. Andrew the First-Called Georgian University, GeorgiaJayalakshmy Ramachandran, Multimedia University, Malaysia
Numerical Investigation of Flow Over Oscillating Cambered Foil at Low Reynolds Number
Authors: Shaik Masuruddin , Hazarika Shyamanta M. 
Published: January 2022

Abstract
This paper aims to investigate the effect of pitching amplitude, mean angle of attack and frequency of oscillation on the propulsive characteristics of a harmonically oscillating cambered airfoil at Reynolds number of 5×104. The flow field around the foil is analyzed to study the influence of the above parameters and to understand the reasons behind the positive thrust force generation. It is observed that the instantaneous force coefficients of the airfoil vary both qualitatively and quantitatively with respect to change in the above-mentioned parameters. A transition of wake from Karman vortex to reverse Karman vortex is observed. It is also observed that the formation and convection of the leading edge vortex over the airfoil surface has a strong impact on the drag-thrust transition. It is also noticed that the change in the location of the pitching axis has a significant influence over thrust force generation and propulsion efficiency of the airfoil.
Low Equivalent Circulating Density Organoclay-Free Invert Emulsion Drilling Fluids
Authors: Wagle Vikrant , AlYami Abdullah , Onoriode Michael , Butcher Jacques 
Published: January 2022

AbstractHigh pressure and high temperature (HPHT) wells especially those with narrow pore/fracture pressure gradient margins present challenges in drilling. Maintaining optimum and low rheology for such wells becomes a challenge where a slight change in the bottom-hole pressure conditions can lead to nonproductive time. However, maintaining low viscosity profile for a drilling fluid can pose a dual challenge in terms of maintaining effective hole-cleaning and barite-sag resistance. This paper describes the formulation of 95pcf medium-density organoclay-free invert emulsion drilling fluids (OCIEF) with a low viscosity profile. The fluids gave lower plastic viscosity (PV), which ensured that the fluid presents low equivalent circulating density (ECD) contribution while drilling/circulating. These fluids were formulated with acid-soluble manganese tetroxide as weighting agent and a specially designed bridging-agent package. The fluids were hot rolled at 300 °F and their filtration and rheological properties were measured. The paper describes the static-aging, contamination, and high pressure/high temperature rheology measurements of the fluids at 300 °F. Particle plugging experiments were performed on the fluids to determine the invasion characteristics and the nondamaging nature of the fluids. These organoclay-free invert emulsion fluids (OCIEFs) were then field-trialed in different wells with good results. Field deployment of the 95pcf organoclay-free invert emulsion fluid helped to maintain the required hole stability in the high temperature and high pressure (HTHP) well. The well was displaced to 95pcf production screen test (PST) fluid and completed with a 4 ½ in. sand screen. The paper demonstrates the superior performance of the developed fluid in achieving the desired lab and field performance.
Prolonged dual hypothermic oxygenated machine preservation (DHOPE-PRO) in liver transplantation: study protocol for a stage 2, prospective, dual-arm, safety and feasibility clinical trial
Authors: Brüggenwirth Isabel M A , Lantinga Veerle A , Rayar Michel , van den Berg Aad P , Blokzijl Hans , Reyntjens Koen M E M , Porte Robert J , de Meijer Vincent E 
Published: January 2022

IntroductionEnd-ischaemic preservation of a donor liver by dual hypothermic oxygenated machine perfusion (DHOPE) for 2 hours prior to transplantation is sufficient to mitigate ischaemia-reperfusion damage and fully restore cellular energy levels. Clinical studies have shown beneficial outcomes after transplantation of liver grafts preserved by DHOPE compared with static cold storage. In addition to graft reconditioning, DHOPE may also be used to prolong preservation time, which could facilitate logistics for allocation and transplantation globally.Methods and analysisThis is a prospective, pseudo-randomised, dual-arm, IDEAL-D (Idea, Development, Exploration, Assessment, Long term study-Framework for Devices) stage 2 clinical device trial designed to determine safety and feasibility of prolonged DHOPE (DHOPE-PRO). The end-time of the donor hepatectomy will determine whether the graft will be assigned to the intervention (16:00–3:59 hour) or to the control arm (4:00–15:59 hour). In total, 36 livers will be included in the study. Livers in the intervention group (n=18) will undergo DHOPE-PRO (≥4 hours) until implantation the following morning, whereas livers in the control group (n=18) will undergo regular DHOPE (2 hours) prior to implantation. The primary endpoint of this study is a composite of the occurrence of all (serious) adverse events during DHOPE and up to 30 days after liver transplantation.Ethics and disseminationThe protocol was approved by the Medical Ethical Committee of Groningen, METc2020.126 in June 2020, and the study was registered in the Netherlands National Trial Registry (https://www.trialregister.nl/) prior to initiation.Trial registration numberNL8740.
Cohort profile: early school years follow-up of the Asking Questions about Alcohol in Pregnancy Longitudinal Study in Melbourne, Australia (AQUA at 6)
Authors: Muggli Evelyne , Halliday Jane , Elliott Elizabeth J , Penington Anthony , Thompson Deanne , Spittle Alicia Jane , Forster Della , Lewis Sharon , Hearps Stephen , Anderson Peter J 
Published: January 2022

PurposeThe Asking Questions about Alcohol in Pregnancy (AQUA) study, established in 2011, is a prebirth cohort of 1570 mother and child pairs designed to assess the effects of low to moderate prenatal alcohol exposure and sporadic binge drinking on long-term child development. Women attending general antenatal clinics in public hospitals in Melbourne, Australia, were recruited in their first trimester, followed up three times during pregnancy and at 12 and 24 months postpartum. The current follow-up of the 6–8-year-old children aims to strengthen our understanding of the relationship between these levels of prenatal alcohol exposure and neuropsychological functioning, facial dysmorphology, brain structure and function.ParticipantsBetween June 2018 and April 2021, 802 of the 1342 eligible AQUA study families completed a parent-report questionnaire (60%). Restrictions associated with COVID-19 pandemic disrupted recruitment, but early school-age neuropsychological assessments were undertaken with 696 children (52%), and 482 (36%) craniofacial images were collected. A preplanned, exposure-representative subset of 146 children completed a brain MRI. An existing biobank was extended through collection of 427 (32%) child buccal swabs.Findings to dateOver half (59%) of mothers consumed some alcohol during pregnancy, with one in five reporting at least one binge-drinking episode prior to pregnancy recognition. Children’s craniofacial shape was examined at 12 months of age, and low to moderate prenatal alcohol exposure was associated with subtle midface changes. At 2 years of age, formal developmental assessments showed no evidence that cognitive, language or motor outcome was associated with any of exposure level.Future plansWe will investigate the relationship between prenatal alcohol exposure and specific aspects of neurodevelopment at 6–8 years, including craniofacial shape, brain structure and function. The contribution of genetics and epigenetics to individual variation in outcomes will be examined in conjunction with national and international collaborations.
Hospital-based multidisciplinary lung cancer care in Australia: a survey of the landscape in 2021
Authors: Brims Fraser J H , Kumarasamy Chellan , Nash Jessica , Leong Tracy L , Stone Emily , Marshall Henry M 
Published: January 2022

IntroductionLung cancer is the leading cause of cancer death in Australia and has the highest cancer burden. Numerous reports describe variations in lung cancer care and outcomes across Australia. There are no data assessing compliance with treatment guidelines and little is known about lung cancer multidisciplinary team (MDT) infrastructure around Australia.MethodsClinicians from institutions treating lung cancer were invited to complete an online survey regarding the local infrastructure for lung cancer care and contemporary issues affecting lung cancer.ResultsResponses from 79 separate institutions were obtained representing 72% of all known institutions treating lung cancer in Australia. Most (93.6%) held a regular MDT meeting although recommended core membership was only achieved for 42/73 (57.5%) sites. There was no thoracic surgery representation in 17/73 (23.3%) of MDTs and surgery was less represented in regional and low case volume centres. Specialist nurses were present in just 37/79 (46.8%) of all sites. Access to diagnostic and treatment facilities was limited for some institutions. IT infrastructure was variable and most sites (69%) do not perform regular audits against guidelines. The COVID-19 pandemic has driven most sites to incorporate virtual MDT meetings, with variable impact around the country. Clinician support for a national data-driven approach to improving lung cancer care was unanimous.DiscussionThis survey demonstrates variations in infrastructure support, provision and membership of lung cancer MDTs, in particular thoracic surgery and specialist lung cancer nurses. This heterogeneity may contribute to some of the well-documented variations in lung cancer outcomes in Australia.
Effect of a postoperative home-based exercise and self-management programme on physical function in people with lung cancer (CAPACITY): protocol for a randomised controlled trial
Authors: Granger Catherine L , Edbrooke Lara , Antippa Phillip , Wright Gavin , McDonald Christine F , Lamb Karen E , Irving Louis , Krishnasamy Meinir , Abo Shaza , Whish-Wilson Georgina A , Truong Dominic , Denehy Linda , Parry Selina M 
Published: January 2022

IntroductionExercise is important in the postoperative management of lung cancer, yet no strong evidence exists for delivery of home-based programmes. Our feasibility (phase I) study established feasibility of a home-based exercise and self-management programme (the programme) delivered postoperatively. This efficacy (phase II) study aims to determine whether the programme, compared with usual care, is effective in improving physical function (primary outcome) in patients after lung cancer surgery.Methods and analysisThis will be a prospective, multisite, two-arm parallel 1:1, randomised controlled superiority trial with assessors blinded to group allocation. 112 participants scheduled for surgery for lung cancer will be recruited and randomised to usual care (no exercise programme) or, usual care plus the 12-week programme. The primary outcome is physical function measured with the EORTC QLQ c30 questionnaire. Secondary outcomes include health-related quality of life (HRQoL); exercise capacity; muscle strength; physical activity levels and patient reported outcomes. HRQoL and patient-reported outcomes will be measured to 12 months, and survival to 5 years. In a substudy, patient experience interviews will be conducted in a subgroup of intervention participants.Ethics and disseminationEthics approval was gained from all sites. Results will be submitted for publications in peer-reviewed journals.Trial registration numberACTRN12617001283369.