bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calorie Restriction and Extracellular ATP on Health and Longevity-
A Perspective
Authors: Agraharam Gopikrishna , Girigoswami Agnishwar , Girigoswami Koyeli 
Published: June 2022

Abstract:
Oxidative stress is known to be generated within the organism by endogenous cellular
mechanisms and can also be generated by external factors. Oxidative stress is known to be involved
in various disease pathologies such as cancer, osteoarthritis, cardiovascular diseases, ageing,
etc. The chronic/acute exposure to oxidative stress can easily damage cellular integrity
through damaging the cellular DNA, mitochondrial DNA, proteins and other organelles that
leads to malfunctioning of organs in the process of ageing. Mitochondrial respiration is one of
the causes involved in the production of reactive oxygen species while generating bioenergetics
(ATP) that provide energy to the cell for maintaining the cellular integrity through the electron
transport chain mechanism, and on the other hand, it generates free-radicals that could cause
damage to the cellular organelles and biomolecules. In relation to this context, longevity through
the calorie restriction method could be due to the generation of lower reactive oxygen species
and age-related diseases in vivo but accelerating loss of brain’s grey matter could be due to the
depletion of energy. This is because intracellular ATP is the vital source of energy and extracellular
ATP acts as signalling molecules. Using advanced technology such as nanotechnology for
the internalization of extracellular ATP, and using it as an external source of energy could maintain
cellular integrity and improve the healthy longevity status when combined with the calorie
restriction method. In this perspective article, we have presented a brief overview and a hypothesis
suggesting that the calorie restriction and extracellular ATP treatment could circumvent the
mitochondrial pathway and alleviate oxidative stress, thereby improving health and enhancing
longevity.
Exploring the Nursing Care Process for Patients with COVID-19: A Grounded Theory Study
Authors: Karimi Zohreh , Saeedinejad Zaker , Fereidouni Zhila , Behnammoghadam Mohammad , Mirzaee Mohammad Saeed , Mousavizadeh Ali , Fazelniya Zahra 
Published: June 2022

Introduction:
A specific model and process of nursing care for patients with COVID-19 has yet to be developed. However, nurses are navigating how to care for patients and themselves in a novel and stressful work environment. A care process is needed that promotes effective nursing for patients’ health and well-being.

Objective:
This study aimed to explore the current nursing care process for patients with COVID-19.

Methods:
The present qualitative study used a grounded theory approach. Participants included 23 nurses working in a hospital COVID-19 ward who were selected through purposive sampling. Semi-structured interviews were conducted with nurses, and data were simultaneously analyzed using MAXQDA software to code the data. Grounded theory with a storyline approach was used to categorize codes to elucidate themes from interviews and check for data saturation. This consists of several steps, including open coding, developing concepts in terms of their properties and dimensions, analyzing data for context, bringing the process into the analysis, and integrating categories.

Results:
Data analysis revealed seven main categories to describe nurses’ conceptions of the care process for COVID-19 patients: ‘patients’ complicated condition’, ‘severe nursing staff shortage’, ‘nursing professionalism’, ‘treatment team collaboration’, ‘work and environmental pressure’, ‘efficacy of care’ and ‘care deficit’. The category of ‘nursing professionalism’ was determined to be the core concept that nurses used to describe their care process.

Conclusion:
Though nurses think highly of their efficacy of care for patients with COVID-19, they face many challenges in their care process that lessen the care they are able to provide for patients and themselves. These include the complex health status of patients, shortage of staff, environmental stresses such as becoming infected, and lack of resources in the hospital. The results of the present study can be used for planning in various fields of nursing, including management, education and clinical training.
Artificial Intelligence Approach in Prostate Cancer Diagnosis: Bibliometric Analysis
Authors: Denysenko Anastasiia , Savchenko Taras , Dovbysh Anatolii , Romaniuk Anatolii , Moskalenko Roman 
Published: June 2022

Background. Prostate cancer is one of the most common male malignancies worldwide that ranks second in cancer-related mortality. Artificial intelligence can reduce subjectivity and improve the efficiency of prostate cancer diagnosis using fewer resources as compared to standard diagnostic scheme.
This review aims to highlight the main concepts of prostate cancer diagnosis and artificial intelligence application and to determine achievements, current trends, and potential research directions in this field, using bibliometric analysis.
Materials and Methods.The studies on the application of artificial intelligence in the morphological diagnosis of prostate cancer for the past 35 years were searched for in the Scopus database using “artificial intelligence” and “prostate cancer” keywords. The selected studies were systematized using Scopus bibliometric tools and the VOSviewer software.
Results. The number of publications in this research field has drastically increased since 2016, with most research carried out in the United States, Canada, and the United Kingdom. They can be divided into three thematic clusters and three qualitative stages in the development of this research field in timeline aspect.
Conclusions. Artificial intelligence algorithms are now being actively developed, playing a huge role in the diagnosis of prostate cancer. Further development and improvement of artificial intelligence algorithms have the potential to automate and standardize the diagnosis of prostate cancer.
Priorities of Economic Cooperation Between the Russian Federation and the People’s Republic of China in Modern Conditions
Authors: Kuzmina V. M. , Podturkin D. S. 
Published: June 2022

In modern conditions, close relations between the two member states of the UN Security Council - Russia and China, are a unique phenomenon and open up tremendous opportunities for the transformation of the existing system of international relations and the transition to a new era. In addition to the obvious prerequisites for cooperation, such as a common border, both powers are in a state of confrontation with the West, oppose interference in their internal affairs, and therefore seek to pursue an independent sovereign policy, defending their own national interests.The purpose is to study the priority areas of Russian-Chinese cooperation in the context of a pandemic and the prospects for this relationship.Objectives: consider the dynamics of trade between Russia and China from 2016 to 2020; to study and visualize the dynamics of the trade balance for 2016-2020; explore the prospects for long-term trade and economic cooperation between the Russian Federation and the People’s Republic of China.Methodology. The article uses the method of statistical analysis of data from the Russia and the China on such indicators as the share of the PRC in the export / import of the Russian Federation, to study the trade balance of the two countries; used the method of comparative analysis of the dynamics of trade between Russia and China for the period from 2016 to 2020, an illustrative-graphical method.Results. Cooperation is based on interaction in various areas, which include joint integration projects and initiatives, which is a feature of modernity and the development of global foreign economic relations. Both sides - Moscow and Beijing - are interested in developing cooperation in the economic sphere, however, their interaction in this area should be more diversified in order to meet the needs of both states in the future and meet their national interests without prejudice to each other. It is necessary to increase the pace and expand the spectrum and boundaries of investment cooperation, extending it to new areas of interaction.Conclusions. It is concluded that the Russian Federation and the PRC are strengthening their partnership, implementing large-scale economic projects, investing in new priority areas: technology and space. The practice of bilateral interaction testifies to the readiness of countries for long-term projects that open up prospects in the economy.
Digital Platforms and Their Role in the Innovative Development of the Economy
Authors: Obukhova A. S. , Chernyikh Ya. V. 
Published: June 2022

Relevance. The use of digital platforms can improve the efficiency of business processes. Digital technologies and the huge amounts of digital data generated by their use radically affect the socio-economic processes taking place in society. The main segments in the field of digital transformation at the moment are: payments and transfers, crowdfunding, asset management, financial marketplace, blockchain, platform technologies.The purpose of the study is to determine the features of the functioning of digital platforms and describe their role in the innovative development of the economy.Objectives: to describe global trends in financial technologies; to characterize the approaches of Russian and foreign authors to the definition of digital platforms; to identify factors contributing to the development of digital platforms; to characterize the change in the structure of the market through the use of digital platforms.Methodology. The study used general scientific methods: comparative analysis, generalization, induction. Results. Based on the conducted research, the following results were obtained: global trends in financial technologies are described; approaches of Russian and foreign authors to the definition of "digital platform" are given; factors influencing the development of digital platforms (changing customer behavior, etc.) are described; the transformation of the market structure under the influence of digital platforms is characterized, which consists in creating multilateral platforms that unite consumers, service providers and stakeholders to exchange values within a larger ecosystem.Conclusions. The digital platform is an integrated information system that provides a multi-sided process of user interaction for the exchange of information. While reducing overall transaction costs, optimizing business processes, increasing the efficiency of the supply chain of goods and services. The most important strategic decision for financial institutions is to create their own digital platform or partnership with existing third-party platforms.
The Burden of Cold Agglutinin Disease on Patients’ Daily Life: Web-Based Cross-sectional Survey of 50 American Patients
Authors: Joly Florence , Schmitt Lisa Anne , Watson Patricia Ann McGee , Pain Emilie , Testa Damien 
Published: June 2022

Background
Cold agglutinin disease (CAD) is a rare disorder, affecting 15% of patients with autoimmune hemolytic anemia. Few studies have assessed CAD symptoms and their impact on daily life, but these studies did not address the patients’ perspectives.

Objective
The aims of this study were to increase the knowledge about CAD through a patient-centric survey and to gain a better understanding of the burden of this disease.

Methods
We conducted an internet-based survey in September 2020 among American patients registered on the CAD Unraveled website and members of the Cold Agglutinin Disease Foundation.

Results
A total of 50 respondents were included in this study. Totally, 90% (45/50) of the patients reported having experienced fatigue. Fatigue was mainly reported on a daily basis, and approximately one-third of these patients (13/45, 29%) said that their fatigue was constant throughout the day. It has also been shown that CAD has a great impact on patients’ physical well-being, emotional well-being, social life, and household finances. The disease varies over time, with or without symptoms. A total of 88% (44/50) of the patients reported previous episodes of the increased intensity or sensitivity of their CAD symptoms, with a mean of 4.5 (SD 5.4) episodes reported during the past year. More than half of the patients (27/50, 54%) considered their disease to be moderate or severe, and 42% (21/50) of the study group reported that their symptoms had worsened since the time of diagnosis.

Conclusions
Our study has provided new data on CAD symptoms, particularly data on the importance and type of fatigue and the fluctuation of CAD symptoms.
Changes in Temporal Properties of Notifiable Infectious Disease Epidemics in China During the COVID-19 Pandemic: Population-Based Surveillance Study
Authors: Zhao Xixi , Li Meijia , Haihambo Naem , Jin Jianhua , Zeng Yimeng , Qiu Jinyi , Guo Mingrou , Zhu Yuyao , Li Zhirui , Liu Jiaxin , Teng Jiayi , Li Sixiao , Zhao Ya-nan , Cao Yanxiang , Wang Xuemei , Li Yaqiong , Gao Michel , Feng Xiaoyang , Han Chuanliang 
Published: June 2022

Background
COVID-19 was first reported in 2019, and the Chinese government immediately carried out stringent and effective control measures in response to the epidemic.

Objective
Nonpharmaceutical interventions (NPIs) may have impacted incidences of other infectious diseases as well. Potential explanations underlying this reduction, however, are not clear. Hence, in this study, we aim to study the influence of the COVID-19 prevention policies on other infectious diseases (mainly class B infectious diseases) in China.

Methods
Time series data sets between 2017 and 2021 for 23 notifiable infectious diseases were extracted from public data sets from the National Health Commission of the People’s Republic of China. Several indices (peak and trough amplitudes, infection selectivity, preferred time to outbreak, oscillatory strength) of each infectious disease were calculated before and after the COVID-19 outbreak.

Results
We found that the prevention and control policies for COVID-19 had a strong, significant reduction effect on outbreaks of other infectious diseases. A clear event-related trough (ERT) was observed after the outbreak of COVID-19 under the strict control policies, and its decreasing amplitude is related to the infection selectivity and preferred outbreak time of the disease before COVID-19. We also calculated the oscillatory strength before and after the COVID-19 outbreak and found that it was significantly stronger before the COVID-19 outbreak and does not correlate with the trough amplitude.

Conclusions
Our results directly demonstrate that prevention policies for COVID-19 have immediate additional benefits for controlling most class B infectious diseases, and several factors (infection selectivity, preferred outbreak time) may have contributed to the reduction in outbreaks. This study may guide the implementation of nonpharmaceutical interventions to control a wider range of infectious diseases.
Severity of COVID-19 after Vaccination among Hemodialysis Patients
Authors: Ashby Damien R. , Caplin Ben , Corbett Richard W. , Asgari Elham , Kumar Nicola , Sarnowski Alexander , Hull Richard , Makanjuola David , Cole Nicholas , Chen Jian , Nyberg Sofia , McCafferty Kieran , Zaman Faryal , Cairns Hugh , Sharpe Claire , Bramham Kate , Motallebzadeh Reza , Anwari Kashif Jamil , Salama Alan D. , Banerjee Debasish 
Published: June 2022

Background and objectives
Patients receiving hemodialysis are at high risk from coronavirus disease 2019 (COVID-19) and demonstrate impaired immune responses to vaccines. There have been several descriptions of their immunologic responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, but few studies have described the clinical efficacy of vaccination in patients on hemodialysis.

Design, setting, participants, & measurements
In a multicenter observational study of the London hemodialysis population undergoing surveillance PCR testing during the period of vaccine rollout with BNT162b2 and AZD1222, all of those positive for SARS-CoV-2 were identified. Clinical outcomes were analyzed according to predictor variables, including vaccination status, using a mixed effects logistic regression model. Risk of infection was analyzed in a subgroup of the base population using a Cox proportional hazards model with vaccination status as a time-varying covariate.

Results
SARS-CoV-2 infection was identified in 1323 patients of different ethnicities (Asian/other, 30%; Black, 38%; and White, 32%), including 1047 (79%) unvaccinated, 86 (7%) after first-dose vaccination, and 190 (14%) after second-dose vaccination. The majority of patients had a mild course; however, 515 (39%) were hospitalized, and 172 (13%) died. Older age, diabetes, and immune suppression were associated with greater illness severity. In regression models adjusted for age, comorbidity, and time period, prior two-dose vaccination was associated with a 75% (95% confidence interval, 56 to 86) lower risk of admission and 88% (95% confidence interval, 70 to 95) fewer deaths compared with unvaccinated patients. No loss of protection was seen in patients over 65 years or with increasing time since vaccination, and no difference was seen between vaccine types.

Conclusions
These data demonstrate a substantially lower risk of severe COVID-19 after vaccination in patients on dialysis who become infected with SARS-CoV-2.
Reflexión para la innovación curricular en enfermería:
Authors: Moscoso Paz 
Published: June 2022

El presente escrito tiene por objeto plantear una reflexión sobre la importancia y la posibilidad de incorporar el conocimiento practico al contenido curricular de la formación inicial en enfermería y sea considerado a la hora de innovar.
Es reconocida la brecha existente entre la teoría y la práctica en Enfermería. Con el fin de colaborar concretamente a disminuir esta brecha entre los años 2013 y 2017 se realizó una investigación posicionada en el paradigma interpretativo que se propuso: desvelar el saber que el experto utiliza en su quehacer profesional para proyectarlo al curriculum. Esta investigación finalmente logró recoger la expresión del saber experto , ello mediante la utilización de la metodología de la práctica reflexiva en cada uno de los medios de recogida de datos tales como la observación permanente, entrevistas incidentales y entrevistas en profundidad a expertos en los tres niveles de atención en salud. Hoy, después de 5 años la evidencia nos sigue informando que, la brecha teórico práctica es un asunto de constante preocupación, es por ello y en vista de los procesos de innovación curricular invitamos a la reflexión.
Reconociendo como posible la explicitación del saber práctico en enfermería, invitamos a integrar a nuestro currículo inicial este conocimiento situado , el cual genera la posibilidad de un currículo enriquecido, contextualizado con la realidad práctica, un currículo que se aleje del papel y se haga más humano.
Policy Decisions and Modal Choice: An Example from the European Union
Authors: RIBBINK DINA , VAN RIEL ALLARD C. R. , SEMEIJN JANJAAP 
Published: June 2022

Abstract
This study addresses the question of how trans-national regulations could stimulate environmentally friendly and socially responsible transportation. Three scenarios are developed for 2010, taking into account various costs related to road, rail, and inland waterway transportation, including costs to society and environmental costs. The attractiveness of different containerized transport modes is calculated for a representative freight corridor in the European Union. The modal split is adjusted for the capacity limitations of the different modes. Analysis of the results reveals that dedicated cargo rail and inland waterways, the two more socially responsible transportation modes, are already relatively attractive to shippers, but lack sufficient capacity to deal with forecasted demand. Further legislative interventions, such as increased taxation, would therefore only increase the financial burden to shippers and society. Important investments appear necessary for the further development of dedicated cargo rail and inland waterways.
North American Container Port Capacity: A Literature Review
Authors: MALONI MICHAEL , JACKSON ERIC C. 
Published: June 2022

AbstractInternational marine container volumes have surged over the last several decades, but North American ports and their supporting container distribution networks have struggled to increase capacity to match this expansion. This article seeks to review and organize existing container network capacity literature into a taxonomy based on the interrelated stakeholders of container flows. The article first establishes the industry capacity situation, then examines research of capacity influences from stakeholders, including port authorities, terminal operators, longshore labor, shippers, railroads, drayage carriers, intermediaries, ocean carriers, governments, and local communities. Ultimately, the article attempts to establish the urgency of container network capacity problems and identify areas needing further research.
The Core Shipper Concept: A Proactive Strategy for Motor Freight Carriers
Authors: DOBIE KATHRYN 
Published: June 2022

Abstract
Motor freight providers today are faced with an increasingly restrictive and demanding operating environment. In an effort to improve safety on the highway, hours-of-service rules have been changed. Security issues also play a role and global trade has become the norm. Shippers' goals of creating the integrated, time-based supply chain using lean inventory strategies necessary for their competitive survival place even greater demands on transportation providers. Yesterday's admonition to better understand shipper concerns and to respond to them is no longer adequate to ensure carrier success. Instead of simply reacting to shipper concerns, carriers must take a proactive approach to determining which shippers they should serve. This approach would enhance the ability of motor carriers to meet their own financial and strategic objectives as they provide shipper-specified services that are intended to enhance the shippers' product/service offerings to their customers. In contrast to focusing on market segments based on shipper similarities, adopting a core shipper strategy requires carriers to take a proactive approach to shipper selection by focusing on the carriers' competencies, resources, and strategic objectives.
Semantics? Service versus Product in Air Transport
Authors: MARETT PAMELA C. 
Published: June 2022

Abstract
The author takes issue with the common practice among air transportation companies of interchanging the words service and product. This is established as case of performance as opposed to pedantry. Successful carriers grasp and embrace a service identity that is unmistakable to employees and customers. Struggling carriers are infused with incongruent identities conveyed to employees and customers through the concurrent usage of service and product. Moreover, the traditional factors indicated for differentiating a service from a product contribute to the creation of a product mentality and obfuscation of a successful service focus.
North American Container Port Capacity: An Exploratory Analysis
Authors: MALONI MICHAEL , JACKSON ERIC C. 
Published: June 2022

Abstract
Major North American container ports were surveyed for their opinions of capacity concerns in consideration of rapidly rising container volumes. The results indicate several areas of concern. For one, the ports expect capacity issues to worsen in the next ten years, implying current congestion problems will also deteriorate. The ports are also highly concerned about a considerable number of capacity drivers, many of which are controlled by other stakeholders including governments, railroads, truck carriers, and labor unions. These results point to a need for an immediate and coordinated approach among multiple stakeholders to address imminent port capacity issues.