bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination chemotherapy consisting of irinotecan, etoposide, and carboplatin for refractory or relapsed neuroblastoma
Authors: Imaya Masayuki , Muramatsu Hideki , Narita Atsushi , Yamamori Ayako , Wakamatsu Manabu , Yoshida Taro , Miwata Shunsuke , Narita Kotaro , Ichikawa Daisuke , Hamada Motoharu , Nishikawa Eri , Kawashima Nozomu , Nishio Nobuhiro , Kojima Seiji , Takahashi Yoshiyuki 
Published: March 2022

AbstractBackgroundPatients with primary refractory and relapsed neuroblastoma have a poor prognosis since safe and effective chemotherapies for these patients are currently limited. The development of new chemotherapy regimens for these patients is imperative to improve survival outcomes.MethodsWe retrospectively analyzed 40 patients with refractory (n = 36) or relapsed (n = 4) neuroblastoma who received irinotecan, etoposide, and carboplatin (IREC) as a second‐line treatment. We evaluated their therapeutic response and the toxicity of IREC. We also assessed the impact of UGT1A1 gene polymorphisms, which are involved in irinotecan metabolism, on outcomes and toxicity.ResultsA total of 112 cycles of IREC were administered to 40 patients with a median of 2 cycles per patient (range, 1–9). Six (15%) patients (UGT1A1 wild‐type [n = 2] and heterozygous [n = 4]) showed objective responses, including partial response (n = 1), tumor shrinkage (n = 4), and improved findings on their MIBG scan (n = 1). Grade 4 neutropenia, grade 4 leukopenia, and grades 3–4 gastrointestinal toxicity were observed in 110 (98%), 88 (79%), and 3 (3%) cycles, respectively. There was no IREC‐related mortality. Patients with UGT1A1 polymorphisms showed a higher frequency of grade 4 leukopenia, but these patients did not have increased treatment‐related mortality or non‐hematologic toxicity.ConclusionsIREC showed an objective response rate of 15% including 1 case with partial response. IREC was well tolerated regardless of UGT1A1 genotype. This study suggests that IREC is a promising second‐line chemotherapy for refractory or relapsed neuroblastoma.
Value creation or value destruction: Conceptualizing the experiential nature of value‐in‐use
Authors: Abid Muhammad Farrukh , Shamim Amjad , Khan Zaheen , Khan Imran 
Published: March 2022

AbstractThe studies to date on service research have provided a generic overview on customer's positive value‐in‐use (value creation) as well as negative value‐in‐use (value destruction). Surprisingly, very little attention is made to exploring the experiential nature of value‐in‐use. This study aims to conceptualize the experiential nature of value‐in‐use where positive value‐in‐use results in value destruction in some situations (and value creation commonly), and negative value‐in‐use results in value creation in some situations (and value destruction normally). By integrating value‐in‐experience and value‐in‐context, the study proposed experience‐dominant logic (EDL) as an important paradigm for value creation in the customer journey. The EDL is backed by the four foundational premises for which the insights are taken from literature as well as through in‐depth interviews with customers and managers of the E‐beauty services. The research also provides a framework for future research avenues as well as various future research directions.
Solanum linnaeanum Leaves: Chemical Profiling of VOCs and Effects on Seed Germination and Early Growth of Monocots and Dicots
Authors: Garzoli Stefania , Orlando Francesca , Iriti Marcello , Vitalini Sara 
Published: March 2022

AbstractSome Solanaceae plants are a rich source of sesquiterpenoid phytoalexins with allelopathic potential. Powder and aqueous extract obtained from the leaves of Solanum linnaeanum Hepper & P.M.L. Jaeger were used to treat the seeds of three target species (Lolium multiflorum Lam., Sinapis alba L. and Trifolium incarnatum L.). Both matrices were evaluated along with untreated controls to determine their toxicity on germination and seedling growth. The results revealed that the pre‐emergence treatments were able to be very effective against all three species in the filter paper test by inhibiting the germination up to 100 %. The effectiveness was reduced by the interaction with soil. Despite this, significant data were obtained, albeit different according to the applied matrix. In general, L. multiflorum was the most sensitive to both the action of the leaf powder and aqueous extract while S. alba was found to be the most resistant to powder activity and T. incarnatum had the strongest response to the extract. For the first time, SPME‐GC/MS technique was used to characterize the volatile chemical profile of S. linnaeanum leaves. The analyses highlighted the presence of different classes of compounds including terpenoids and sesquiterpenoids potentially useful in the fight against noxious plants both in natural and cultivated ecosystems.
Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of Their Localization and Function in Live Cells
Authors: Mann Guy , Sadhu Pradeep , Brik Ashraf 
Published: March 2022

AbstractUbiquitin (Ub) and its related small Ub like modifier (SUMO) are among the most influential protein post‐translational modifications in eukaryotes. Unfortunately, visualizing these modifications in live cells is a challenging task. Chemical protein synthesis offers great opportunities in studying and further understanding Ub and SUMO biology. Nevertheless, the low cell permeability of proteins limits these studies mainly for in vitro applications. Here, we introduce a multiplexed protein cell delivery approach, termed MBL (multiplexed bead loading), for simultaneous loading of up to four differentially labeled proteins with organic fluorophores. We applied MBL to visualize ubiquitination and SUMOylation events in live and untransfected cells without fluorescent protein tags or perturbation to their endogenous levels. Our study reveals unprecedented involvements of Ub and SUMO2 in lysosomes depending on conjugation states. We envision that this approach will improve our understanding of dynamic cellular processes such as formation and disassembly of membraneless organelles.
Predischarge transthoracic echocardiogram after TAVI – Is it really necessary?
Authors: Upadhyay Ankit , Jneid Hani 
Published: March 2022

Key Points

Predischarge TTE after an uncomplicated TAVI procedure may not be necessary as long as an adequate intraprocedural echocardiogram and predischarge clinical assessment are performed.
With the adoption of the newer TAVI platforms, which carries lower rates of paravalvular leak, the elimination of predischarge TTE in appropriately selected patients is reasonable and may be cost‐saving.
More studies are needed using larger patient cohorts to identify subsets of patients in whom predischarge TTE can be safely eliminated.
Sound and light editorial: The ROCK cohort II study
Authors: Alasnag Mirvat 
Published: March 2022

Key Points

Complications of distal Left Main revascularization are of higher clinical significance given the larger territory portended.
Intravascular imaging is a strong predictor of outcomes following distal Left Main percutaneous revascularization at one year compared with angiography alone.
No significant difference in the predictive value of OCT and IVUS can be detected.
Esthetic and functional rehabilitation of peg‐shaped maxillary lateral incisors: Practical recommendations
Authors: Omeish Nadine , Nassif Ali , Feghali Sara , Vi‐Fane Brigitte , Bosco Julia 
Published: March 2022

AbstractPeg‐shaped maxillary lateral incisors cause many functional and esthetic major consequences in affected patients. Their esthetic and functional rehabilitations are often multidisciplinary, involving different clinical procedures like periodontal, orthodontic, or prosthodontic procedures. No exhaustive protocol has been established to improve their comprehensive management by general dentists or specialists. The aim of this article is to elaborate a simplified clinical protocol of complete management of peg‐shaped maxillary lateral incisors by a multidisciplinary team (general practitioners, orthodontists, and prosthodontists). A clinical case of two peg‐shaped maxillary lateral incisors completely rehabilitated with multidisciplinary approaches including orthodontic treatment and restoration by veneers and direct composite resin, according to the established protocol. Extraoral, intraoral, and smile clinical analysis are crucial to ensure optimal rehabilitation. Treatment results previsualization via wax‐up and/or mock‐up play a key role in the communication between practitioner and patient to help the latter make decision. These options also facilitate the achievement of a multidisciplinary approach by accurately estimating the number of dental movements and the type of restorations that are most suitable to the presenting clinical situation.
Staphylococcal endocarditis with meningitis and basal ganglia infarcts mimicking meningococcemia
Authors: Giri Subarna , Shrestha Bhushan , Gajurel Bikram Prasad , Sapkota Dharmendra , Gautam Niraj , Shrestha Ashish 
Published: March 2022

AbstractStaphylococcus aureus is one of the common causes of infective endocarditis (IE). IE can present with various neurological complications such as stroke, brain abscess, and meningitis, the mortality rate can be very high in such cases.
Liu regression after random forest for prediction and modeling in high dimension
Authors: Arashi Mohammad , Lukman Adewale F. , Algamal Zakariya Y. 
Published: March 2022

AbstractIn the modern era, using advanced technology, we have access to data with many features, and therefore, feature engineering has become a vital task in data analysis. One of the challenges in model estimation is to combat multicollinearity in high‐dimensional data problems where the number of features (
) exceeds the number of samples
. We propose a novel, yet simple, strategy to estimate the regression parameters in a high‐dimensional regime in the presence of multicollinearity. The proposed approach enjoys the good properties of the random forest and the simple structure of a class of linear unified estimators. We give a fast and straightforward algorithm to estimate the regression coefficients when
and multicollinearity exist. Numerical investigation reveals the superior performance of the method in test mean squared error. The technique is also applied to melting chemical data, where we conducted an estimation among 4885 features and discussed advantages.
Engineering of Portable Smartphone Integrated with Liposome‐Encapsulated Curcumin for Onsite Visual Ratiometric Fluorescence Imaging of Hypochlorite
Authors: Shen Yizhong , Zhu Chunlei , Wei Yunlong , Chen Huanhuan , Wu Zeyu , Ye Yingwang , Han De‐Man 
Published: March 2022

AbstractPrecisely onsite monitoring of hypochlorite (ClO−) is of great significance to guide its rational use, reducing/avoiding its potential threat toward food safety and human health. Considering ClO− could quench fluorescence of curcumin (CCM) by oxidizing the o‐methoxyphenol of CCM into benzoquinone, a portable ratiometric fluorescence sensor integrated with smartphone was designed for realizing the visual point‐of‐care testing (POCT) of ClO−. The amphiphilic phospholipid polymer was used as carrier to wrap curcumin, forming a novel liposome‐encapsulated CCM, which provided a scaffold to bind with [Ru(bpy)3]2+ through electrostatic interaction, thus assembling [Ru(bpy)3]2+‐functionalized liposome‐encapsulated CCM ([Ru(bpy)3]2+@CCM‐NPs). Further integrated with smartphone, visual imaging of [Ru(bpy)3]2+@CCM‐NPs could be achieved and the accurate onsite detection of ClO− could be realized with a detection limit of 66.31 nM and a linear range of 0.2210 to 80.0 μM. In addition, the sensor could monitor ClO− in real samples with an onsite detection time of ∼154.0 s.
Artificial intelligence empowered threat detection in the Internet of Things: A systematic review
Authors: Soltani Nasim , Rahmani Amir Masoud , Bohlouli Mahdi , Hosseinzadeh Mehdi 
Published: March 2022

SummaryInternet of Things (IoT) is a new phenomenon that proposes novel business opportunities. IoT allows the world to be programmable and might provide several benefits for organizations. Based on the IoT survey, cyber‐security issues are among the most extensive and complicated challenges faced by IoT devices. Threat detection is considered a preventive measure against malware threats, ransomware, and attacks, which become more serious each year because of the dramatic rise in malware attacks. This article investigates threat detection techniques that fall into three categories: malware detection, attack detection, and ransomware detection, published from 2017 to August 2021. We examine solutions, techniques, features, classifiers, and tools proposed by IoT researchers. Some questions are proposed, and answering the questions may help the researchers suggest a more efficient solution in future works. Furthermore, the achievement and disadvantages of each study are discussed. Finally, based on the reviewed studies, some open challenges and practical measures to future directions are suggested, worth further studying and researching threat detection techniques in the IoT.
The effects of neoadjuvant chemotherapy and interval debulking surgery on body composition in patients with ovarian cancer
Authors: Vitarello John , Goncalves Marcus D. , Zhou Qin C. , Iasonos Alexia , Halpenny Darragh F. , Plodkowski Andrew , Schwitzer Emily , Mueller Jennifer J. , Zivanovic Oliver , Jones Lee W. , Cadoo Karen A. , Konner Jason A. 
Published: March 2022

AbstractBackgroundThe aim of this study was to quantify changes in body composition during ovarian cancer treatment and relate these changes to rates of complete gross resection (CGR).MethodsOne hundred two patients with stage III or IV ovarian cancer who underwent neoadjuvant chemotherapy (NACT) followed by interval debulking surgery were a part of a prospectively collected database that included computed tomography scans at three time points—diagnosis, following NACT, and following debulking surgery. Skeletal muscle, visceral adipose, and subcutaneous adipose tissue volumes were obtained from a 30‐mm volumetric slab beginning at the third lumbar vertebrae.ResultsFollowing NACT, skeletal muscle volume was significantly reduced (352.5 to 335.0 cm3, P < 0.001), whereas adiposity was unchanged. Body mass index (BMI) and skeletal muscle volume were significantly lower in patients who achieved CGR (P < 0.05). When these patients were stratified by BMI, the significant association of skeletal muscle to CGR was limited to patients with a BMI < 25 kg/m2 (P = 0.007).ConclusionSkeletal muscle volume was significantly reduced in patients undergoing NACT for ovarian cancer. Non‐overweight patients were more likely to achieve CGR if they had lower skeletal muscle volume. Use of volumetric‐based measurement for ascertaining body composition should be explored further.
Management of anorexia prevents skeletal muscle wasting during cisplatin‐based chemotherapy for thoracic malignancies
Authors: Miyawaki Eriko , Naito Tateaki , Nakashima Kazuhisa , Miyawaki Taichi , Mamesaya Nobuaki , Kawamura Takahisa , Kobayashi Haruki , Omori Shota , Wakuda Kazushige , Ono Akira , Kenmotsu Hirotsugu , Murakami Haruyasu , Mori Keita , Takahashi Toshiaki 
Published: March 2022

AbstractBackgroundCancer‐associated skeletal muscle loss often occurs in patients with advanced lung cancer who are receiving chemotherapy. This study aimed to elucidate the impact of chemotherapy‐induced nausea and vomiting (CINV) or anorexia on muscle wasting.MethodsIn this post‐hoc analysis of a phase II clinical trial of antiemetic agents, chemotherapy‐naïve Japanese patients with thoracic malignancies were prospectively recruited between May and October 2015. Total control of CINV was defined as the absence of nausea and vomiting without rescue therapy 0–120 h after each course of chemotherapy. Non‐anorexia was defined as having no anorexia or having an anorexia grade no higher than ‘1’ during the 3 month period following chemotherapy initiation. Skeletal muscle mass was measured by computed tomography, and lumbar skeletal muscle index (LSMI) was calculated.ResultsAmong 29 patients, CINV was totally controlled in 7 (24%) and grade 2 or 3 anorexia was observed in 10 (34%). The LSMI significantly decreased across the entire cohort (mean ± standard error of the mean: −3.1 ± 0.6 cm2/m2, P < 0.01); this reduction was similar among patients with and without total control of CINV (−4.1 ± 1.3 vs. −2.8 ± 0.7 cm2/m2, P = 0.38). Patients with anorexia experienced a larger decrease in LSMI than did those without anorexia during the study period (−5.4 ± 0.9 vs. −1.9 ± 0.7 cm2/m2, P < 0.01).ConclusionsSignificant skeletal muscle mass depletion was observed despite well‐controlled CINV. Continuous oral food intake may be required throughout the course of cisplatin‐based chemotherapy.
Body composition, sarcopenia, and quality of life in patients with oesophageal cancer before resection surgery and at follow‐up: a cohort study
Authors: Persson Jan , Fagevik Olsén Monika , Iresjö Britt‐Marie , Smedh Ulrika 
Published: March 2022

AbstractAimsOesophageal cancer is associated with dysphagia and reduced caloric intake. Body composition and prevalence of sarcopenia in patients with oesophageal cancer before and after surgery are not well known. The aims were to (i) describe body composition and sarcopenia, physical performance, and quality of life (QoL) in a cohort of patients with oesophageal cancer before surgery with curative intent; (ii) investigate alterations in body composition as a consequence of the surgery at 1 and 3 months post‐operatively; and (iii) investigate if pre‐operative measures are correlated to morbidity, length of stay, QoL, or mortality.Methods and resultsAn observational study was performed in 76 consecutive patients with oesophageal cancer planned for open surgery with curative intent. Data were collected from the patient history database. QoL data were derived from the European Organization for Research and Treatment of Cancer QLQ‐OES18 questionnaire. Pre‐operatively, the patients displayed normal body mass index despite that almost 20% were sarcopenic, 86% had a lowered physical performance level, and 37% of the patients were severely malnourished. All body composition variables except fat mass declined up to 3 months after surgery. No pre‐operative biometric measure or QoL item correlated with risk for complications. High physical performance, female sex, and high global QoL score positively predicted overall survival.ConclusionsSevere malnourishment was common in patients judged suitable for surgery in spite of normal body mass index. Neither pre‐operative malnutrition nor sarcopenia was independent risk factor for morbidity or overall mortality. Oesophageal surgery causes long‐lasting catabolic effects, highlighting the importance of optimal peri‐operative and post‐operative nutrition.
Speech perception in noise in children with dyslexia: Does speech sound disorder matter?
Authors: Mari Giorgia , Picciotti Pasqualina Maria , Martina Bianca Maria , Loperfido Antonella , Zagari Felicia , Proietti Ilaria , Longobardi Ylenia , D'Alatri Lucia 
Published: March 2022

The aim of this observational cohort study with a control group is to compare consonant perception skills in quiet and in noise in children with typical language and learning development and in children with dyslexia, with and without Speech Sound Disorder (SSD). Three groups were included: A control group of twenty children with normal reading abilities and typical language development, twelve children with dyslexia and typical language development and thirteen children with dyslexia and SSD. All subjects received a consonant recognition test in three different listening conditions (quiet, + 10 and 0 Signal‐to‐Noise Ratio). In all test conditions, children with dyslexia and SSD had significantly lower consonant recognition scores than the control group and the children with dyslexia and typical language development (p < .0001). The poorer performances observed in children with dyslexia and SSD may be explained by impaired phonological processing underlying both conditions.
Choosy cannibals: Targeted consumption of conspecific hatchlings by larval cane toads is triggered by species‐specific defensive toxins
Authors: Crossland Michael R. , Shine Richard , DeVore Jayna L. 
Published: March 2022

AbstractIn many species, cannibalism is uncommon and involves nonselective consumption of conspecifics as well as heterospecifics. However, within their invasive Australian range, cane toad larvae (Rhinella marina) specifically target and voraciously consume the eggs and hatchlings of conspecifics, often extirpating entire clutches. In contrast, toad larvae rarely consume the eggs and hatchlings of native frogs. Here, we use laboratory studies to demonstrate that this selective consumption is triggered by species‐specific chemical cues: maternally‐invested bufadienolide toxins that otherwise defend cane toad eggs and hatchlings against predators. We find that these cues stimulate feeding behaviors in toad tadpoles, such that the addition of bufadienolide toxins to the water column increases predation on eggs, not only of conspecifics, but also of native anuran species that are otherwise usually ignored. In contrast, we find that cannibalism rates on conspecific hatchlings are high and unaffected by the addition of bufadienolide cues. The maternally‐invested toxins present in conspecific eggs may therefore be more easily detected post‐hatching, at which point tadpole feeding behaviors are induced whether or not additional toxin cues are present. As bufadienolide cues have previously been found to attract toad tadpoles to vulnerable hatchlings, our present findings demonstrate that the same toxin cues that attract cannibalistic tadpoles also induce them to feed, thereby facilitating cannibalism through multiple behavioral effects. Because native fauna do not produce bufadienolide toxins, the species specificity of these chemical cues in the Australian landscape may have facilitated the evolution of targeted (species‐specific) cannibalism in invasive cane toad populations. Thus, these bufadienolide toxins confer cost (increased vulnerability to cannibalism in early life‐stages) as well as benefit (reduced vulnerability to predation by other taxa).