bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health complexity assessment in primary care: A validity and feasibility study of the INTERMED tool
Authors: Oliveira Camila Almeida de , Weber Bernardete , dos Santos Jair Lício Ferreira , Zucoloto Miriane Lucindo , de Camargo Lisa Laredo , Zanetti Ana Carolina Guidorizzi , Rzewuska Magdalena , de Azevedo-Marques João Mazzoncini 
Published: February 2022

Background
Health complexity includes biological, psychological, social, and health systems. Having complex health needs is associated with poorer clinical outcomes and higher healthcare costs. Care management for people with health complexity is increasingly recommended in primary health care (PHC). The INTERMED complexity assessment grid showed adequate psychometric properties in specialized settings. This study aimed to evaluate INTERMED’s validity and feasibility to assess health complexity in an adult PHC population.

Method
The biopsychosocial health care needs of 230 consecutive adult patients from three Brazilian PHC services were assessed using the INTERMED interview. Participants with a total score >20 were classified as “complex”. Quality of life was measured using the World Health Organization Quality of Life BREF (WHOQOL-BREF); symptoms of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS); social support using the Medical Outcomes Study—Social Support Survey (MOS-SSS); comorbidity levels using the Charlson Comorbidity Index (CCI). We developed two questionnaires to evaluate health services use, and patient perceived feasibility of INTERMED.

Results
42 participants (18.3%) were classified as “complex”. A moderate correlation was found between the total INTERMED score and the total scores of WHOQOL-BREF (rho = - 0.59) and HADS (rho = 0.56), and between the social domains of INTERMED and MOS-SSS (rho = -0.44). After adjustment, the use of PHC (β = 2.12, t = 2.10, p < 0.05), any other health care services (β = 3.05, t = 3.97, p < 0.01), and any medication (β = 3.64, t = 4.16, p < 0.01) were associated with higher INTERMED scores. The INTERMED internal consistency was good (ω = 0.83), and the median application time was 7 min. Patients reported satisfaction with the questions, answers, and application time.

Conclusion
INTERMED displayed good psychometric values in a PHC population and proved promising for practical use in PHC.
Interaction between bacteria and cholesterol crystals: Implications for endocarditis and atherosclerosis
Authors: Boumegouas Manel , Raju Manjunath , Gardiner Joseph , Hammer Neal , Saleh Yehia , Al-Abcha Abdullah , Kalra Apoorv , Abela George S. 
Published: February 2022

Background
The interaction between pathogenic bacteria and cholesterol crystals (CCs) has not been investigated. However, CCs are found extensively in atherosclerotic plaques and sclerotic cardiac valves. Interactions between pathogenic bacteria and CCs could provide insights into destabilization of atherosclerotic plaques and bacterial adhesion to cardiac valves.

Methods
Staphylococcus aureus and Pseudomonas aeruginosa were used to assess in vitro bacterial adhesion to CCs and proliferation in the presence of CCs compared to plastic microspheres and glass shards as controls. Ex vivo studies evaluated bacterial adhesion to atherosclerotic rabbit arteries compared to normal arteries and human atherosclerotic carotid plaques compared to normal carotid arteries. Scanning electron microscopy (SEM) was used to visualize bacterial adhesion to CCs and confocal microscopy was used to detect cholesterol binding to bacteria grown in the presence or absence of CCs.

Results
In vitro, S. aureus and P. aeruginosa displayed significantly greater adhesion, 36% (p<0.0001) and 89% (p<0.0001), respectively, and growth upon exposure to CCs compared to microspheres or glass shards. Rabbit and human atherosclerotic arteries contained significantly greater bacterial burdens compared to controls (4× (p<0.0004); 3× (p<0.019), respectively. SEM demonstrated that bacteria adhered and appeared to degrade CCs. Consistent with this, confocal microscopy indicated increased cholesterol bound to the bacterial cells.

Conclusions
This study is the first to demonstrate an interaction between bacteria and CCs showing that bacteria dissolve and bind to CCs. This interaction helps to elucidate adhesion of bacteria to sclerotic valves and atherosclerotic plaques that may contribute to endocarditis and plaque destabilization.
An exploration of barriers and enablers to the conduct and application of research among complementary and alternative medicine stakeholders in Australia and New Zealand: A qualitative descriptive study
Authors: Veziari Yasamin , Kumar Saravana , Leach Matthew J. 
Published: February 2022

BackgroundMost studies examining complementary and alternative medicine (CAM) stakeholder engagement with evidence-based practice have relied on quantitative research methods, which often fail to capture the nuances of this phenomena. Using qualitative methods, this study aimed to explore the experiences of CAM stakeholders regarding the barriers and enablers to the conduct and application of research.MethodsThis research was guided by a qualitative descriptive framework. CAM practitioners and researchers of multiple CAM disciplines from across Australia and New Zealand were invited to share their personal perspectives of the study phenomena. Semi-structured interviews were conducted via Zoom, which were audio-recorded and transcribed verbatim. Rigour strategies were applied to ensure the credibility of results. The transcript was analysed using thematic analysis.ResultsCAM stakeholders identified an array of barriers and enablers to the conduct and application of research within their disciplines. The barriers and enablers that emerged were found to be inter-connected with two similar constructs: capacity and culture. Captured within the construct of capacity were five themes—lack of resources, inadequate governance/leadership, lack of competency, bias directed from outside and within CAM, and lack of time for research. Within the construct of culture were two themes—intrinsic perceptions in CAM, and lack of communication within and outside CAM.ConclusionsPromoting evidence-based practice and engaging with research in CAM continues to face challenges. This study, for the first time, has highlighted the multitude of interlinked barriers that confront CAM stakeholders when engaging with research. These findings highlight the need for a concerted and targeted approach to tackle these challenges.
Value-Creating Global Citizenship Education for Sustainable Development: Strategies and Approaches, Namrata Sharma (2020)
Authors: Chhikara Alankrita 
Published: February 2022

Review of: Value-Creating Global Citizenship Education for Sustainable Development: Strategies and Approaches, Namrata Sharma (2020)
Cham: Palgrave Macmillan, 166 pp.,
ISBN 978-3-03058-062-9, e-book, €42.79
Teaching and Learning for Comprehensive Citizenship: Global Perspectives on Peace Education, Candice C. Carter (ed.) (2020)
Authors: Ward Caitlyn 
Published: February 2022

Review of: Teaching and Learning for Comprehensive Citizenship: Global Perspectives on Peace Education, Candice C. Carter (ed.) (2020)
Routledge, New York, NY, 194 pp.,
ISBN 978-1-00024-621-6, $160
Metrological traceability and clinical traceability of laboratory results – the role of commutability in External Quality Assurance
Authors: Jones Graham R.D. , Delatour Vincent , Badrick Tony 
Published: February 2022

Abstract
The role of an External Quality Assurance (EQA) program is generally seen as providing a service to routine laboratories that their analytical performance is satisfactory and stimulating corrective action in the event of poor results. It is recognised that an ideal EQA program uses materials that are commutable with patient samples and have values assigned by higher-order reference methods. Despite this, most routine EQA programs use materials without verified commutability and use consensus means (based on either peer group or all laboratories) as target values. We propose an ongoing role for EQA programs using non-commutable materials and consensus targets to support the measurement services of routine laboratories. This is provided the relevant comparators supplied by the laboratory, e.g. reference intervals and clinical decision points, are based on the same or equivalent measurement system as is used by the laboratory. Materials without verified commutability often have certain practical advantages, which may include the range of analyte concentrations, verified stability, replicate samples and, significantly, lower costs. Laboratories using such programs need to be aware of the limitations, especially comparing results from different measurement systems. However, we also recognise that as well as individual laboratories, data from EQA programs informs manufacturers, professional organisations, clinical guideline writers and other medical bodies For consideration beyond an individual laboratory, proper assessment of differences between measurement systems (results harmonization) and demonstration of correct implementation of metrological traceability (methods trueness) become vital, and for that purpose, commutability of EQA materials and traceability of target values are required.
Generalized de Bruijn graphs
Authors: Malyshev Fedor M. 
Published: February 2022

Abstract
We study the graphs of transitions between states of nonautonomous automata that provide, with independent equiprobable input signs, an equiprobable distribution on the set of all states in the minimum possible number of cycles, as is the case of the de Bruijn graphs corresponding to shift registers. It is proved that in the case of a binary input alphabet, there are at least 12r−33 pairwise nonisomorphic directed graphs with 2
r
vertices that have this property. All graphs of this type with 8 and 9 vertices are found.
Effect of CuO nanoparticle additive on optical, photocatalytic and surface properties of TiO2 mesoporous nanoparticles
Authors: Ahmadi Maryam , Koozegar Kaleji Behzad 
Published: February 2022

Abstract
In this study, composite nanoparticles of TiO2–CuO (TC) were synthesized using the sol–gel method. Tetra butylorthotitanate and copper (II) nitrate trihydrate were used as precursors to titanium dioxide and copper oxide, respectively. Ethanol was used as a solvent. Dynamic light scattering, X-ray diffraction, UV–Vis spectroscopy, nitrogen adsorption–desorption isotherm, field emission scanning electron microscopy and transmission electron microscopy were used to characterize the nanoparticles. The synthesized photocatalytic nanoparticles were used to degrade methylene blue dye solution as a model of organic pollutant under UV and visible light irradiation. The TC sample calcined at 550 °C has the highest photocatalytic percentage under visible light (33.14 %) and the best photocatalytic activity at 650 °C under ultraviolet light (40 %). The pure TiO2 sample has an adsorption edge of 365 nm with a band gap energy of 3.39 eV and the mesoporous TiO2–CuO sample with an absorption edge wavelength of 375 nm has a band gap energy of 3.30 eV at 350 °C. According to the X-ray photoelectron spectroscopy study, Ti was predominantly chemically present as Ti 4+. Cu was found to be a cation with a capacity of two (Cu 2+).
Extracting network based attack narratives through use of the cyber kill chain: A replication study
Authors: Weathersby Aaron , Washington Mark 
Published: February 2022

Abstract
The defense of a computer network requires defenders to both understand when an attack is taking place and understand the larger strategic goals of their attackers. In this paper we explore this topic through the replication of a prior study “Extracting Attack Narratives from Traffic Datasets” by Mireles et al. [Athanasiades, N., et al., Intrusion detection testing and benchmarking methodologies, in First IEEE International Workshop on Information Assurance. 2003, IEEE: Darmstadt, Germany]. In their original research Mireles et al. proposed a framework linking a particular cyber-attack model (the Mandiant Life Cycle Model) and identification of individual attack signatures into a process as to provide a higher-level insight of an attacker in what they termed as attack narratives. In our study we both replicate the original authors work while also moving the research forward by integrating many of the suggestions Mireles et al. provided that would have improved their study. Through our analysis, we confirm the concept that attack narratives can provide additional insight beyond the review of individual cyber-attacks. We also built upon one of their suggested areas by exploring their framework through the lens of Lockheed Martin Cyber Kill Chain. While we found the concept to be novel and potentially useful, we found challenges replicating the clarity Mireles et al. described. In our research we identify the need for additional research into describing additional components of an attack narrative including the nonlinear nature of cyber-attacks and issues of identity and attribution.
Assessment of anti-inflammatory and antioxidant activity of quercetin–rutin blend (SophorOx™) – an invitro cell based assay
Authors: Shanmugasundaram Devanand , Roza James Martin 
Published: February 2022

Abstract

Objectives
Quercetin & Rutin, are bioactive compounds that are widely used for various therapeutic properties. There’s been growing interest in the biological activities of these polyphenols belonging to the class of flavonoids known to have various health benefits. Quercetin is now popularly recognized as a phytochemical remedy for a plethora of disease groups such as metabolic syndrome (more specifically diabetes), obesity/weight management and mood disorders. Due to its unique chemical structure, the most prominent property of Quercetin is probably its antioxidant capability. It acts as a free radical scavenger to form resonance-stabilized phenoxyl radicals. Certain in
vitro studies have also shown quercetin to have anti-viral, anti-carcinogenic and platelet aggregation properties. Rutin has also been shown to exert diverse biological effects such as anti-tumor activities, reduction of inflammatory cytokines and antimicrobial activities. The current study was designed to further confirm the antioxidant and anti-inflammatory property of a Quercetin–Rutin blend (SophorOx™).

Methods
The analysis was performed in a cell-based assay using RAW 264.7 macrophage cell line. SophorOx™ was screened for cytotoxicity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to obtain optimum concentrations for experimental assays. SophorOx™ was measured for pro-inflammatory cytokine levels (TNF-α & IL-6) and nitric oxide (NO) levels. Additionally, ROS (reactive oxygen species) levels in RAW cells were estimated using a cell-permeant reagent 2′7′-dichlorofluorescein diacetate (DCFH-DA).

Results
SophorOx™ at 10 µM concentration, exhibited an anti-inflammatory property with significant inhibitory levels of TNF-α (∼28.25%) and IL-6 (∼32.25%). SophorOx™ at similar concentrations reduced nitric oxide levels to 70.55% in lipopolysaccharide (LPS) stimulated RAW 264.7 cells. Raw 264.7 cells stimulated with LPS exhibited a significant increase in intracellular ROS and this was significantly reduced (78.2% reduction) at lower concentrations (0.3 µM) of SophorOx™.

Conclusions
The anti-inflammatory effects of SophorOx™ were investigated in LPS stimulated RAW 264.7 macrophages. Data suggests, that SophorOx™ reduced levels of nitric oxide, intracellular ROS and pro-inflammatory cytokines (TNF-α & IL-6) at low concentrations without affecting the viability of RAW cells. Present invitro trial suggests that SophorOx™ is a potent antioxidant and anti-inflammatory agent and displays a prominent ability to block mediators of oxidative stress and inflammation.
Sensing performance of Au–Ag bimetal coated planar waveguide having polyaniline polymer film for biosensing applications
Authors: Yadav Dharamjeet , Kumar Rajendra , Kumar Sushil , Sharma Gaurav , Yadav Gulab Chand , Singh Vivek 
Published: February 2022

Abstract
Bimetal clad planar waveguide having polyaniline polymer as a guiding layer is proposed and studied for biosensing applications. The dispersion relation and reflectivity of the proposed sensor is obtained using transfer matrix method. The sensing performance and stability of proposed waveguide-based sensor is optimized using different volume fraction of Ag–Au bimetal. The volume fraction 1 represents pure Ag metal coating waveguide that shows maximum sensing performance in our all considered cases. In this case, maximum obtain sensitivity, detection accuracy and quality parameter is 74.140, 11.199 and 559.970°/RIU respectively, at the cover refractive index 1.410. Since, resonance angle and full width at half maxima of resonance peak decreases with increase of Ag metal percentage in Ag–Au bimetal therefore the presence of Au metal decreases the sensing performance of the sensor. Hence, a small volume fraction of Au metal is recommended for higher sensitivity with stability.
Transitional care management in patients with auto-inflammatory diseases: experience of cooperation of a paediatric and adult centre
Authors: Soscia Francesca , Sicignano Ludovico Luca , Verrecchia Elena , Ardenti Morini Francesca , Massaro Maria Grazia , Civitelli Fortunata Sabrina , Ferrari Federica , Rigante Donato , Cortis Elisabetta , Manna Raffaele 
Published: February 2022

Abstract

Objectives
Auto-inflammatory Diseases (AIDs) are a group of diseases with a strong genetic component, inducing an inappropriate activation of innate immunity. The patients with pediatric onset will face the transitional care (TC) from a pediatrician to an adult care setting, during the critical phase of the adolescence. That implies a risk of failure and drop out, due to the different approach of pediatrician compared to the adult doctor. To describe the model of TC for AIDs from a paediatric to adult centre of two hospitals in Rome, and to pointing out the different steps emerged from specific experiences.

Methods
In November 2020, a Board of paediatricians and internists discussed their experience to identify “hot topics” for a successful management of TC.

Results
The Board agreed on the optimal time for the transition (12–18 years). Specific elements to be considered are the reached level of emotional and intellectual maturity, and the clinical stability of the disease.

Conclusions
The TC of patients with chronic AIDs, requires a strong cooperation to define the adequate follow-up, and to guarantee the compliance to the treatment. This model allows us to investigate AIDs complex cases, requiring a long period of observations.
Impoliteness in Twitter diplomacy: offence giving and taking in Middle East diplomatic crises
Authors: Altahmazi Thulfiqar Hussein M. 
Published: February 2022

AbstractDrawing on linguistic impoliteness, this paper examines offence giving and taking in Twitter Diplomacy in the Middle East, explicating how Twitter affordances shape the context in which offence can be employed strategically in diplomatic communication. The dataset includes all the tweets posted by the Iranian Foreign Minister over a period of 10 years (totaling 659 tweets). The argument expounded in this paper is based on two assumptions. First, impoliteness notions can be effective in analyzing and theorizing diplomatic Tweeting in the times of crisis. Second, diplomatic offence can be employed to manage conflicts and legitimize foreign policies. The results show that diplomatic offence is characteristically explicit, which is vital to index the offender’s disaffiliation from the target’s values. Offence giving is used to present self-image through attacking the adversary’s identity or values, whereas offence taking is utilized to moralize international politics through foregrounding the adversary’s moral idiosyncrasies or legal violations. In effect, diplomatic offence is used to do impression management that aims at gaining moral capital. Twitter affordances allow the affective and moral stances associated with offence giving and taking to be publicized to online and offline audience, encouraging them to align with the producer’s values and political standing.
Constant upper bounds on the matrix exponential norm
Authors: Nechepurenko Yuri M. , Zasko Grigory V. 
Published: February 2022

AbstractThis work is devoted to the constant (time-independent) upper bounds on the function ∥ exp(tA)∥2wheret⩾ 0 andAis a square matrix whose eigenvalues have negative real parts. Along with some constant upper bounds obtained from known time-dependent exponential upper bounds based on the solutions of Lyapunov equations, a new constant upper bound is proposed that has significant advantages. A detailed comparison of all these constant upper bounds is carried out using 2 × 2 matrices and matrices of medium size from the well-known NEP collection.
The “empirical vocation” of the semiotics of Umberto Eco in his works on the media and mass communication
Authors: Traini Stefano 
Published: February 2022

Abstract
In this article, I attempt to set out and discuss the main trajectories of Umberto Eco’s thinking on the media and mass communication, based on a review of the author’s writings on these subjects. What emerges from the study is Eco’s attention to the public and to forms of reception; his attention to the relationship between media communication and reality, which involves investigating the concept of “truth” in an area such as that of mass communication; his cross-media view of information, seen from a pluralistic and polyphonic viewpoint; the ethical tension that is always present in Eco’s work; his unfailing propensity for teaching. What emerges above all is the way in which the theoretical and practical tools used by Eco were developed in the context of reflections on the media and mass communication: an indication that alongside its “philosophical vocation,” Eco’s semiotics was always characterized also by an essential “empirical vocation.”
Deriving formula to simulate the radiological behavior during LOCA in open pool type reactor
Authors: Abdelhady Amr 
Published: February 2022

This study aims to model the radiological consequences that result from loss of coolant accident in open pool research reactor of 22 MW power. The loss of coolant accident results from rupture in the cooling systems of the reactor and consequently results in decreasing the water level in the reactor pool. Decreasing the water level, that represents the shielding material above the reactor core, results in increasing the dose rate in the top region in the reactor pool as well as the reactor building. LOCA normally results in shutting down the reactor due to the radioprotection system provided in the upper region of the reactor pool. A failure in shutdown systems of the reactor during LOCA is rare but expected and it represents the worst case. So, evaluating LOCA from the radiological point of view must be investigated for the safe shutdown mode as well as the failure of shutdown case. The study also includes occurring LOCA for shutdown reactor taking the decay time into consideration. ORIGEN-S module from scale system was used to estimate the delayed neutrons and gamma rays from the core for the shutdown mode. KENO-VI module from Scale system was used to estimate the prompt neutrons and gamma rays generated from the core for the failure case. Then, MAVRIC/Scale module was used to estimate the dose rate at the top point of the reactor pool for the two cases during LOCA.Studying the dose rate during LOCA aims to determine the water level that verifies the radiological safety limit at the top point of the reactor pool for the two cases. The calculations introduced a relationship between the water level that verifies the permissible radiological limit (WL) and the decay time (DT) in the range between 0 to 30 d.