bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult intussusception: an 11-year study of diagnosis, clinic manifestations, and the optimal operation
Authors: Sun Ming-ze , Li Zhong-min , Shu Zhen-bo , Wu Qi , Liu Xue 
Published: June 2022

Abstract
BackgroundIntussusception can occur at any age and is common in children but less common in adults. In addition, adult intussusception differs from intussusception in children with respect to etiology and clinical presentation, which makes the diagnosis difficult. MethodsThis retrospective analysis assessed the clinical manifestations, etiology, diagnosis, and treatment of adult intussusception in 51 adult patients at the Department of Gastrointestinal Surgery of China-Japan Union Hospital of Jilin University from January 2010 to December 2020.ResultsThe mean age of the cohort was 54.43±18.21 years, and 42 patients were diagnosed by abdominal ultrasonography and abdominal computed tomography (CT). Among them, 76.5% (39/51) had abdominal pain, 11.8% (6/51) had blood in stool, and 5.9% (3/51) had a palpable abdominal mass. Of these, 62.7% had tumors: malignant accounted for 39.2% (20/51) and benign accounted for 23.5% (12/51). CT is the preferred imaging method with a sensitivity of 92.2%, while colonoscopy provides a complementary diagnosis in patients involving the colon. All patients underwent surgical treatment, including 21.6% (11/51) laparoscopic surgery, 74.5% (38/51) open surgery, and 5.9% (3/51) intussusception reduction during the operation. The average operation time of the open group was 133.27±43.75 min and the average hospital stay was 16.24±12.55 days, while the average operation time of the laparoscopic group was 140.50±46.15 mins, and the average hospital stay was 16.60±16.98 days (P>0.05).ConclusionThe most common cause of adult intussusception is underlying pathological change. CT is the preferred method for adult intussusception diagnosis, and laparoscopic surgery is the preferred treatment for adult intussusception.
Assessment of flood susceptibility areas using novel hybrid approach of neural network over the Tumen River Basin, China
Authors: Jin Ri , Quan Hechun , Jin Aifen , Jin Guangri , Zhu Weihong , Lin Zhehao 
Published: June 2022

Abstract
Floods caused by rainstorms occur almost every year in Tumen River Basin. The floods caused severe damage to local residents, property and the ecological environment. For reducing the damage of floods, it is necessary to produce the flood susceptibility map. For mapping the flood prone areas, four algorithms such as genetic algorithm (GA), particle swarm optimization (PSO), artificial fish swarm algorithm (AFSA) and artificial bee colony algorithm (ABC) were used to optimize back propagation (BP) neural network respectively. The accuracy of the model was evaluated by Receiver Operating characteristic (ROC), root mean square error(RMSE) and mean absolute error (MAE). A total number of 222 flooded and un-flooded locations were identified. 155 locations of which were randomly selected to training the model, and the remaining 67 locations were used to validate the model. A total of thirteen flood conditioning factors，including altitude, slope, aspect, curvature, Topographic Wetness Index (TWI), Stream Power Index (SPI), Sediment Transport Index (STI), distance to river, landuse, rainfall, lithology, runoff coefficient and soil type were used in the proposed models. The area under the curve (AUC) obtained from ROC indicated that AFSA-BP showed a high accuracy (99.91%), and ABC-BP had the lowest prediction accuracy (97.28%). According to the generated flood susceptibility map, about 13% of Tumen River Basin is under very high flood susceptibility. The distance to river, rainfall, altitude and land use have the greatest impact on flood susceptibility. The results showed that the BP model optimized by the four algorithms is an effective and reliable tool for mapping the flood susceptibility. The flood susceptibility map can be used in flood prevention strategies.
UWB Indoor Localization in LOS and NLOS
Authors: kim Heejae , Joe Inwhee 
Published: June 2022

Abstract
As wireless communication technology develops, services using user’s location information are also increasing and becoming important. Among many technologies that can measure position, ultra wideband (UWB) is being used in many fields of robot and human positioning systems. A high-precision technology using UWB can find targets with an error of a few centimeters, from industrial robot operations to drones used in search and rescue operations. In this paper, indoor positioning is performed using UWB boards in line of sight (LOS) and non line of sight (NLOS) situations. With the long short-term memory (LSTM) Deep Learning Algorithm, we propose a method for compensating location errors and predicting a more accurate location. In the LOS situation, the location was measured based on fingerprinting using four anchors and tags. The measured distance values were classified into training and test dataset. By applying these distance values to the LSTM, it was confirmed that the position error was compensated. In the NLOS situation, the quality factor was measured for each obstacle by placing four types of obstacles (no obstacles, metal, mirror, multipath) between the anchor and the tag at a distance of 4 meters. By applying the measured values to the LSTM, it was confirmed that the position error was compensated by detecting an abnormal signal occurring in the UWB board. Finally, the experimental results show that the proposed method can provide more accurate position compensation and prediction in LOS and NLOS environments.
Topo-Iberia CGPS network: A new 3D crustal velocity field in the Iberian Peninsula and Morocco based on eleven years (2008–2019)
Authors: García-Armenteros Juan A. 
Published: June 2022

Abstract
Topo-Iberia network covering the Spanish part of the Iberian Peninsula and Morocco was established in 2008. After the first publication in 2015 of the horizontal velocity field based on the analysis of the first four activity years (2008–2012), a new 3D velocity field based on eleven years (2008–2019) is presented in this paper. Double-differencing technique with GAMIT software and precise point positioning (PPP) technique with GipsyX software are used for GPS processing obtaining loosely constrained solutions, and the methodology merging both solutions within a Kalman filter (GLOBK) is exposed. Position time series analysis carried out is described and results obtained by each processing strategy are compared. The combined velocity solution is presented in this paper as the new horizontal velocity field and the first vertical velocity field of Topo-Iberia CGPS network. A global view of Topo-Iberia stations quality for the processed period is also presented for the first time. The results are in good accordance with previous publications except in Betic Cordillera. Smallest and highest residual displacements with respect to Eurasia occur in northern Iberia and Morocco respectively. The results could confirm that a clockwise block rotation would have been occurring at present in the northern branch of the Gibraltar Arc, which present-day undergoing a northwest-southeast convergence rate of 3.6 mm/yr. A general low subsidence is observed in the Iberian Peninsula except for some isolated stations presenting uplift.
Evaluation of the root system of Vetiver grass (Chrysopogon zizanioides L. Roberty) using different sampling method
Authors: Holanda Francisco Sandro Rodrigues , Santos Luiz Diego Vidal , Pedrotti Alceu , Filho Renisson Neponuceno de Araújo , Sartor Lucas Resmini , Santos-Sobrinho Valter Rubens Alcantara , de Jesus Rayssa Juliane Souza , Silva Priscila Angel de Oliveira , Andrade Keila Maria Araújo 
Published: June 2022

Abstract
Background: The objective of this work was to evaluate the root system of Vetiver grass through different methodologies. The trench method evaluated 50 images in 10 x 10 cm squares in its vertical face. The volumetric ring method uses a metallic ring with a volume of 50 cm³ (diameter ≅ 4.6 cm and height ≅ 3.0 cm) to collect samples in the same trench´s vertical face. A hand auger hole method worked with soil samples and roots removed from the surface up to 0.50 m depth. The monolith method comprises a 0.50 m wide, 0.50 m long, and 1 m deep monolith. A spatial correlation between root volume and root area was observed in the kriging maps by the volumetric ring method. Results: The root area values for both the volumetric ring method and the hand auger hole method were similar, up to 0.10 to 0.20 m. Among the analyzed variables, the root area showed the best correlation coefficient among the analyzed root methods, especially those that use the limited spatial distribution by its sampling collection, such as the volumetric ring method and the hand auger hole method (r = 0.526).Conclusions: The studied methods can be separated into two groups: those that provide more detailed information about the behavior and distribution of the root system, such as trench and monolith methods. The trench method requires turning the soil. Both require greater spatial coverage, and therefore have greater precision, and the methods that better describe the morphological characteristics of the features, such as the volumetric ring method.
Efficacy of SARS-CoV-2 primary and booster vaccine doses in CAR-T recipients
Authors: Abid Muhammad Bilal , Abid Muhammad Abbas , Uyemura Bradley , Suelzer Elizabeth 
Published: June 2022

Abstract
While multiple studies have demonstrated diminished humoral response to vaccinations against COVID-19 in immunocompromised patients, data are limited in chimeric antigen receptor T-cell (CAR-T) recipients. In this systematic review, we identified 18 studies through a manual search of key databases that reported SARS-CoV-2 vaccine responses in 236 CAR-T recipients. This included data from 184 recipients of CD19-directed CAR-T and 29 BCMA- or CD138-directed CAR-T therapy. The pooled humoral response rate across 18 studies was 25.8% (61/236), irrespective of number of vaccine doses. The vaccine response rate among patients who only completed their primary vaccine series with 2 doses, was 27.6% across 15 studies (50/181). The pooled seroconversion rate after receiving a third or fourth dose of vaccine was 20% in 4 studies (11/55). Recipients of CD19-directed CAR-T products had a seroconversion rate of 19.2% (25/130) compared to 71.4% (20/28) among those who received BCMA- or CD138-directed therapies after completion of a primary course of vaccination. Given a high COVID-19 attributable mortality and blunted seroconversion rates in CAR-T recipients, these results provide guidance to cellular therapy centers in terms of identifying higher risk patients. In the setting of ongoing highly transmissible variants of concern, the results are hypothesis-generating in terms of potential for earlier utilization of novel strategies such as the use of monoclonal antibodies in those CAR-T recipients less likely to respond to vaccines.
How concurrent bilateral anodal tDCS of the primary motor cortex and cerebellum affects postural balance in healthy young adults? A randomized, double-blind sham-controlled study
Authors: Behrangrad Shabnam , Zoghi Maryam , Kidgell Dawson , Mansouri Farshad , Jaberzadeh Shapour 
Published: June 2022

Abstract
Background
Anodal transcranial direct current stimulation (a-tDCS) applied to the primary motor cortex (M1), or cerebellum (CB) can enhance the postural balance in healthy young adults.
Objective
In a randomized double-blinded crossover, the sham-controlled study design was utilized to explore the effects of concurrent bilateral anodal tDCS of M1 and CB (concurrent bilateral a-tDCSM1+CB) on the balance indices.
Methods
Twenty-one healthy adults participated in this study. Each participant received a-tDCS of 2 mA 20 minutes in four pseudo-randomized, counterbalanced sessions, separated by at least seven days (7.11 days ± 0.65). These sessions were bilateral M1 stimulation (bilateral a-tDCSM1), bilateral cerebellar stimulation (bilateral a-tDCSCB), concurrent bilateral a-tDCSM1+CB, and sham stimulation (bilateral a-tDCSSham). Postural balance was evaluated by different tests, including four conditions of the unilateral stance test (US), four conditions of the modified Clinical Test of Sensory Interaction on Balance (mCTSIB), and reaction time (RT), movement velocity (MVL) and directional control (DCL) in limits of stability test (LOS), were recorded before and immediately after the intervention to measure balance changes.
Results
Concurrent bilateral a-tDCSM1+CB significantly improved RT, MVL, DCL, US and mCTSIB (p ˂0.05). Also, bilateral a-tDCSM1 significantly improved the RT, MVL, and DCL (p ˂0.05). However, no significant changes were found after bilateral a-tDCSCB. Interestingly, concurrent bilateral a-tDCSM1+CB showed shorter RT compared to bilateral a-tDCSM1 (p = 0.015) and bilateral a-tDCSCB (p = 0.06).
Conclusions
These results confirm that the concurrent bilateral a-tDCSM1+CB significantly improves the balance in young, healthy adults and has better effects than the bilateral a-tDCSM1.
Non-intubated deep paralysis: a new anaesthesia strategy for vocal cord polypectomy
Authors: Fan Yichen , Chi Xiaoying , Zhu Danyan , Yin Jiemin , Liu Yaling , Su Diansan 
Published: June 2022

Abstract
Background Vocal cord polyp is common otorhinolaryngological disease, traditionally treated by vocal cord polypectomy under a supporting laryngoscope with general anaesthesia. Although it is safe and controllable, it would cause some anaesthesia complications. Moreover, the complex process of general anaesthesia may significantly reduce surgical efficiency. Avoiding these problems remains an important issue.Methods All patients were subjected to the standard non-intubated deep paralysis (NIDP) protocol consisting of four phases. An emergency plan was launched when NIDP cannot be implemented successfully. Patient characteristics, blood gas and monitoring data were collected during NIDP. Data concerning satisfaction, complications and duration of anaesthesia and recovery were collected to assess its effectiveness.Result Among 20 enrolled patients, the success rate of NIDP was 95%. Only one patient failed in completing NIDP. Blood gas analysis revealed that the partial pressure of oxygen and carbon dioxide was maintained at safe levels. Monitoring during NIDP revealed fluctuations in mean arterial pressure between 110 and 70 mmHg, and the heart rate was stable at 60–100 beats per minute. The duration of anaesthesia and postoperative recovery were 13.0±2.84 and 5.47±1.97 min, respectively. All patients and surgeons were satisfied with NIDP, and no complications were detected before discharge.Conclusion NIDP can be safely applied to patients and can replace general anaesthesia in vocal cord polypectomy. It can significantly reduce the duration of anaesthesia and postoperative recovery. No anaesthesia complications occurred without intubation, and patients and surgeons were satisfied with NIDP.Trial registrations This single-centre, prospective study was registered on clinicaltrial.gov (NCT04247412) on 30th July 2020.
When to Share Your Genome to an Online Community: A Game Theoretic Approach to Balance Privacy Risks and Familial Benefits
Authors: Guo Jia , Clayton Ellen Wright , Kantarcioglu Murat , Vorobeychik Yevgeniy , Wooders Myrna , Wan Zhiyu , Yin Zhijun , Malin Bradley 
Published: June 2022

Abstract
As recreational genomics continues to grow in its popularity, many people are afforded the opportunity to share their genomes in exchange for various services, including third-party interpretation (TPI) tools, to understand their predisposition to health problems and, based on genome similarity, to find extended family members. At the same time, these services have increasingly been reused by law enforcement to track down potential criminals through family members who disclose their genomic information. While it has been observed that many potential users shy away from such data sharing when they learn that their privacy cannot be assured, it remains unclear how potential users’ valuations of the service will affect a population’s behavior. In this paper, we present a game theoretic framework to model interdependent privacy challenges in genomic data sharing online. Through simulations, we find that in addition to the boundary cases when 1) no player and 2) every player joins, there exist pure-strategy Nash equilibria when a relatively small portion of players choose to join the genomic database. The result is consistent under different parametric settings. We further examine the stability of Nash equilibria and illustrate that the only equilibrium that is resistant to a random dropping of players is when all players join the genomic database. Finally, we show that when players consider the impact that their data sharing may have on their relatives, the only pure strategy Nash equilibria are when either no player or every player shares their genomic data.
WITHDRAWN: Insights into the combustion and transport processes in chemically reacting flow systems
Authors: Chen Junjie 
Published: June 2022

Abstract
Computational fluid dynamics simulations are made possible by the development of numerical schemes that are highly accurate in temporal and spatial discretization and stable at high Reynolds numbers. A fundamental understanding of the stabilization mechanisms of a flame within very small spaces by the cavity method is of both fundamental and practical significance. However, the precise mechanism by which the cavity method generally provides increased flame stability remains unclear and warrants further study. Computational fluid dynamics simulations are performed to understand the overall small-scale combustion characteristics of chemically reacting flow systems. The effects of different design factors on flame stability are investigated. The roles of combustion and transport processes in chemically reacting flow systems are discussed, particularly the transport of momentum, energy, and chemical species in fluids. The results indicate that the cavity structure can induce recirculation of hot products, thereby improving flame stability. The exterior heat loss and wall thermal conductivity are vital in determining the flame stability of the chemically reacting flow system. Further improvement in flame stability can be achieved by using anisotropic walls. A critical issue of fuel-rich cases is the loss of combustion efficiency. Combustion at the microscale can offer many advantages. Faster ignition and more efficient heat transfer can be achieved, but the design is challenging due to the loss of flame stability. The principles developed and illustrated here for combustion systems are important not only for the rational design and development of chemical reactors but also for scientific research involving coupled transport processes and chemical reaction in flow systems.
Analysis and Application of Transversely Isotropic Chemical Poroelastic Media Subjected to Point Liquid and Chemical Sources
Authors: Fu Longming , Han Jiadong , Fan Xin , Zhang Baojian , Wu Di 
Published: June 2022

Abstract
Shale is important as oil, natural gas, or mineral resource evaluation. Due to the high chemical activity of shale, it is prone to interact with the pore fluid phase during mining and drilling operations, which can change its mechanical properties resulting in damage. Essentially, shale is a chemical poroelastic material, and researching the coupling effects on shale resource development is unpredictable. In order to study the physicochemical interactions within porous materials, the general solutions of chemical poroelastic materials are derived in terms of the constitutive and governing equations. An example of a chemical poroelastic body subjected to point fluid and chemical sources is given to show the application of the general solutions, and the accuracy of the derivation is verified by using COMSOL Multiphysics software which provides a certain theoretical basis for future research.
Caffeic acid phenyl ester induces apoptosis in HT29 cells through the modulation of MAPK mediated cellular proliferation and heat shock proteins
Authors: Yahya Showket , Sudhandiran Ganapasam 
Published: June 2022

Abstract
Colorectal cancer is among the most prevalent epithelial origin gastrointestinal cancers in the world with over 2 million cases detected every year. Multiple factors contribute to the progression of colonic tumours. Emerging evidences suggest that nutrient deprivation leads to enormous oxidative stress, leading to diminished growth of cancer cells and maintenance of homeostasis. Colon cancer cells evade cell cycle check points and apoptosis leading to cellular proliferation. In this study, HT29 colorectal cancer cells were grown under serum supplemented and deprived condition and the effect of Caffeic acid phenethyl ester (CAPE) was tested. Cell cycle analysis revealed that CAPE could inhibit the cell cycle progression in G2/M phase. DNA fragmentation analysis and TUNEL assay were performed to evaluate the apoptosis inducing property of CAPE. Clonogenic and migration assays confirmed that CAPE could inhibit cancer stemness and invasiveness, respectively. p38 Mitogen activated protein kinase and JNK are notorious signalling mediators that directly links inflammation, cell death and expression of cancer signalling proteins. Western blot analysis reveal that CAPE inhibits inflammation and regulates the expression of p38 MAPK, JNK and ERK1/2, critical mediators of cancer cell progression. Heat shock proteins also known as molecular chaperones play a decisive role in colon cancer and facilitates maintenance of protein folding and homeostasis. In this study, CAPE regulates the expression of Hsp90, 70 and 40 in HT29 cells. The co-immunoprecipitation interaction between p38MAPK and HSP’s validate the strong protein-protein interaction. The results of this study demonstrates that CAPE induces apoptosis in HT29 cells through the involvement of Hsp’s and MAPK pathway.
G3BP1 Regulates Breast Cancer Cell Proliferation and Metastasis
Authors: Liu Shuang , Tian Shaoping , He Xin , Ideozu Justin Eze , Wang Rui , Geng Hua , Yue Dan 
Published: June 2022

Abstract
Breast cancer is a leading cause of death and morbidity among female cancers. Several factors, including hormone levels, lifestyle, and dysregulated RNA-binding proteins, have been associated with the development of breast cancer. Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) and protein kinase C, Zeta isoform (PKCζ) are oncogenes implicated in numerous cancers, including breast cancers. However, their interaction and role in promoting breast cancer proliferation and metastasis have not been well-characterized. In the present study, we demonstrated that G3BP1 expression is elevated in breast cancer and that knockdown of G3BP1 diminished the proliferation and metastasis of breast cancer cells. Mechanistically, we identified a series of proliferating and metastasis-related properties, including chemotaxis, migration, Golgi polarity localization, and actin polymerization, that were modulated by G3BP1 knockdown. We found that G3BP1 and PKCζ co-localized and interacted intracellularly, and they co-underwent membrane translocation under EGF stimulation. Following the knockdown of G3BP1, we observed the membrane translocation and phosphorylation of PKCζ were significantly impaired, suggesting that G3BP1 regulates the activation of PKCζ. Our findings indicate that G3BP1 plays multiple roles in breast cancer cell proliferation and metastasis. The activation of PKCζ by G3BP1 may be the specific mechanism underlying the process.