The COVID-19 Community Research Partnership: a multistate surveillance platform for characterizing the epidemiology of the SARS-CoV-2 pandemic
Authors:   The COVID-19 Community Research Partnership, Wierzba Thomas F , Sanders John Walton , Herrington David , Espeland Mark A , Williamson John , Mongraw-Chaffin Morgana , Bertoni Alain , Alexander-Miller Martha A , Castri Paola , Mathews Allison , Munawar Iqra , Seals Austin Lyles , Ostasiewski Brian , Ballard Christine Ann Pittman , Gurcan Metin , Ivanov Alexander , Zapata Giselle Melendez , Westcott Marlena , Blinson Karen , Blinson Laura , Mistysyn Mark , Davis Donna , Doomy Lynda , Henderson Perrin , Jessup Alicia , Lane Kimberly , Levine Beverly , McCanless Jessica , McDaniel Sharon , Melius Kathryn , O'Neill Christine , Pack Angelina , Rathee Ritu , Rushing Scott , Sheets Jennifer , Soots Sandra , Wall Michele , Wheeler Samantha , White John , Wilkerson Lisa , Wilson Rebekah , Wilson Kenneth , Burcombe Deb , Saylor Georgia , Lunn Megan , Ordonez Karina , O'Steen Ashley , Wagner Leigh , Runyon Michael S , McCurdy Lewis H , Gibbs Michael A , Taylor Yhenneko J , Calamari Lydia , Tapp Hazel , Ahmed Amina , Brennan Michael , Munn Lindsay , Dantuluri Keerti L , Hetherington Timothy , Lu Lauren C , Dunn Connell , Hogg Melanie , Price Andrea , Leonidas Marina , Manning Melinda , Rossman Whitney , Gohs Frank X , Harris Anna , Priem Jennifer S , Tochiki Pilar , Wellinsky Nicole , Silva Crystal , Ludden Tom , Hernandez Jackeline , Spencer Kennisha , McAlister Laura , Weintraub William , Miller Kristen , Washington Chris , Moses Allison , Dolman Sarahfaye , Zelaya-Portillo Julissa , Erkus John , Blumenthal Joseph , Romero Barrientos Ronald E , Bennett Sonita , Shah Shrenik , Mathur Shrey , Boxley Christian , Kolm Paul , Franklin Ella , Ahmed Naheed , Larsen Moira , Oberhelman Richard , Keating Joseph , Kissinger Patricia , Schieffelin John , Yukich Joshua , Beron Andrew , Teigen Johanna , Kotloff Karen , Chen Wilbur H , Friedman-Klabanoff DeAnna , Berry Andrea A , Powell Helen , Roane Lynnee , Datar Reva , Reilly Colleen , Correa Adolfo , Navalkele Bhagyashri , Min Yuan-I , Castillo Alexandra , Ward Lori , Santos Robert P , Anugu Pramod , Gao Yan , Green Jason , Sandlin Ramona , Moore Donald , Drake Lemichal , Horton Dorothy , Johnson Kendra L , Stover Michael , Lagarde William H , Daniel LaMonica , Maguire Patrick D , Hanlon Charin L , McFayden Lynette , Rigo Isaura , Hines Kelli , Smith Lindsay , Harris Monique , Lissor Belinda , Cook Vivian , Eversole Maddy , Herrin Terry , Murphy Dennis , Kinney Lauren , Diehl Polly , Abromitis Nicholas , Pierre Tina St , Heckman Bill , Evans Denise , March Julian , Whitlock Ben , Moore Wendy , Arthur Sarah , Conway Joseph , Gallaher Thomas R , Johanson Mathew , Brown Sawyer , Dixon Tina , Reavis Martha , Henderson Shakira , Zimmer Michael , Oliver Danielle , Jackson Kasheta , Menon Monica , Bishop Brandon , Roeth Rachel , King-Thiele Robin , Hamrick Terri S , Ihmeidan Abdalla , Hinkelman Amy , Okafor Chika , Bray Brown Regina B , Brewster Amber , Bouyi Danius , Lamont Katrina , Yoshinaga Kazumi , Vinod Poornima , Suman Peela A , Denbel Giera , Lo Jason , Mayet-Khan Mariam , Mittal Akash , Motwani Reena , Raafat Mohamed , Schultz Evan , Joseph Aderson , Parkeh Aalok , Patel Dhara , Afridi Babar , Uschner Diane , Edelstein Sharon L , Santacatterina Michele , Strylewicz Greg , Burke Brian , Gunaratne Mihili , Turney Meghan , Zhou Shirley Qin , Tjaden Ashley H , Fette Lida , Buahin Asare , Bott Matthew , Graziani Sophia , Soni Ashvi , Diao Guoqing , Renteria Jone , Mores Christopher , Porzucek Abigail , Laborde Rebecca , Acharya Pranav , Guill Lucy , Lamphier Danielle , Schaefer Anna , Satterwhite William M , McKeague Anne , Ward Johnathan , Naranjo Diana P , Darko Nana , Castellon Kimberly , Brink Ryan , Shehzad Haris , Kuprianov Derek , McGlasson Douglas , Hayes Devin , Edwards Sierra , Daphnis Stephane , Todd Britnee , Goodwin Atira , Berkelman Ruth , Hanson Kimberly , Zeger Scott , Hopkins Johns , Reilly Cavan , Edwards Kathy , Gayle Helene , Redd Stephen 
Published: November 2022

Abstract
The COVID-19 Community Research Partnership (CCRP) is a multisite surveillance platform designed to characterize the epidemiology of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) pandemic. This article describes the CCRP study design and methodology. The CCRP includes two prospective cohorts, one with six health systems in the mid-Atlantic and southern USA, and the other with six health systems in North Carolina. With enrollment beginning in April 2020, sites invited persons within their healthcare systems as well as community members to participate in daily surveillance for symptoms of COVID-like illnesses, testing, and risk behaviors. Participants with electronic health records (EHRs) were also asked to volunteer data access. Subsets of participants, representative of the general population and including oversampling of populations of interest, were selected for repeated at-home serology testing. By October 2021, 65 739 participants (62 261 adult and 3478 pediatric) were enrolled, with 89% providing syndromic data, 74% providing EHR data, and 70% participating in one of the two serology sub-studies. An average of 62% of the participants completed a daily survey at least once a week, and 55% of the serology kits were returned. The CCRP provides rich regional epidemiologic data and the opportunity to more fully characterize the risks and sequelae of SARS-CoV-2 infection.