bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tiempo y evaluación del aprendizaje
Authors: Murcia Padilla Julio César 
Published: March 2022

El giro que se ha dado en la educación por los cambios en la mirada del aprendizaje —y no tanto en la enseñanza— ha centrado su problemática en las prácticas pedagógico-evaluativas, tanto más en las estrategias didácticas para el aprendizaje que en las estrategias pedagógicas para la enseñanza. Ello ha implicado un giro de 180 ° en la manera como se concibe el saber y el conocimiento, y la acción del docente en esta mediación entre el saber, su ejercicio docente y la procura del aprendizaje del estudiante de manera profunda y auténtica. Esta conversión del eje alrededor del cual gira la educación formal ha posibilitado y generado diseños curriculares que respondan a estas nuevas dinámicas de relación pedagógica y didáctica del aprendizaje de los estudiantes y de la práctica docente concreta en el aula
Aseismic Slip and Cascade Triggering Process of Foreshocks Leading to the 2021 Mw 6.1 Yangbi Earthquake
Authors: Liu Xiaoge , Xu Wenbin , He Zilong , Fang Lihua , Chen Zhidan 
Published: March 2022

AbstractUnderstanding the nature of foreshock evolution is important for earthquake nucleation and hazard evaluation. Aseismic slip and cascade triggering processes are considered to be two end-member precursors in earthquake nucleation processes. However, to perceive the physical mechanisms of these precursors leading to the occurrence of large events is challenging. In this study, the relocated 2021 Yangbi earthquake sequences are observed to be aligned along the northwest–southeast direction and exhibit spatial migration fronts toward the hypocenters of large events including the mainshock. An apparent static Coulomb stress increase on the mainshock hypocenter was detected, owing to the precursors. This suggests that the foreshocks are manifestations of aseismic transients that promote the cascade triggering of both the foreshocks and the eventual mainshock. By jointly inverting both Interferometric Synthetic Aperture Radar and Global Navigation Satellite Systems data, we observe that the mainshock ruptured a blind vertical fault with a peak slip of 0.8 m. Our results demonstrate that the lateral crustal extrusion and lower crustal flow are probably the major driving mechanisms of mainshock. In addition, the potential seismic hazards on the Weixi–Weishan and Red River faults deserve further attention.
Study to examine correlation between lifetime prevalence of traumatic events and alopecia areata
Authors: Kulkarni Omkar Shivanand , Gulanikar Anirudha Dharnidhar 
Published: March 2022

Alopecia areata is commonly occurring autoimmune hair condition presenting as well demarcated patches of hair loss. Majority of existing literature examines relation of acute stressful events to onset of alopecia areata. We examined correlation of lifetime prevalence of traumatic events to occurrence of alopecia areata. Structured questionnaire called presumptive lifetime stressful event score was administered to clinically diagnosed cases of alopecia areata visiting tertiary care centre. Financial traumatic events were statistically more significantly associated with male sex (p value of 0.04884). Educational traumatic events were more common in younger age group i.e., &#60;30 years of age (p value 0.00044). Familial traumatic events (p value 0.03846) as well as lifestyle changes (p value 0.04338) were more common in &#62;30 years. It was observed that majority of category shows educational stress (24%), followed by financial stress. (22%).12 patients of 50 (24%) had recurrent disease with mean disease duration of 12 months and average number of traumatic events to be 1.41 while those with single episode (N=38) had average disease duration to be 5.94 months and experienced mean 1.36 traumatic events
A case of Pemphigoid gestationis- Successfully managed with good outcome
Authors: Goel Shitij , Chaudhary Azra Ferheen , Bansal Mansi , Srivastava Ruchi , Ahuja Mayuri 
Published: March 2022

State of pregnancy can manifest with various physiological and pregnancy specific dermatoses. The physiological changes include pigmentary, vascular and connective tissue changes. The specific dermatoses includes Atopic Eruption of Pregnancy, Polymorphic eruption of Pregnancy, Pemphigoid Gestationis and Intrahepatic Cholestasis of Pregnancy. Pemphigoid gestationis (PG) is a rare autoimmune bullous disease exclusively associated with pregnancy. It develops during the third trimester of pregnancy and is associated with maternal and foetal complications. Here, we report a case of PG which was successfully managed with systemic steroids with a favourable outcome.
Z badań terenowych w powiecie szczycieńskim (O dezintegracji grupy kulturowej Mazurów)
Authors: Biliński Piotr 
Published: March 2022

Artykuł dotyczy badań grupy współczesnych Mazurów powiatu szczycieńskiego. Społeczność ta stanowi przykład grupy regionalnej (kulturowej), ukształtowanej na terenach o wpływach pruskich, germańskich i słowiańskich, czyli w warunkach charakterystycznych dla pogranicza kultur. Szczególnie zaakcentowana jest tu ważna i w pełni niezbadana problematyka zróżnicowania, ewaluacji i perspektyw dalszych losów tej grupy. Dominacja czynników natury historycznej i cywilizacyjnej powodowała, że przez wieki ludność mazurska ulegała procesom akulturacji, asymilacji i adaptacji, a ostatnio też wzmożonej unifikacji i globalizacji. Tym ostatnim sprzyjają dziś media i informatyzacja życia społecznego, a jednostki społeczne wybiórczo przejmują określone wzorce i zachowania.
Survey on Major Insect Pests and Management Practices Adopted for Georgia Golf Courses and Sod Farms
Authors: Gireesh Midhula , Joseph Shimat V. 
Published: March 2022

Abstract
Because turfgrass is maintained in various settings, such as golf courses, lawns, and commercially grown in sod farms, it is critical to understand its major insect pests and management practices. A survey was conducted to determine the major insect pests and current management practices in the commercial turfgrass industries in Georgia. A total of 32 respondents representing golf courses and sod farms participated in the survey. A significantly greater number of respondents represented golf courses (75% of 32 respondents) than sod farms (25%). The respondents (n =31) identified fall armyworm, Spodoptera frugiperda J.E. Smith (32.5%), white grubs, Phyllophaga spp. (20.8%), mole crickets (Orthoptera: Gryllotalpidae; 16.9%), and others (22%) as major pests in comparison to billbugs, Sphenophorus spp. (7.8%) and chinch bugs, Blissus spp. (0%). Of 31 respondents, 64.5% applied insecticides two to five times and 22.5% respondents applied insecticides 5–10 times for insect management each year. Among nonchemical tools (n=24), most respondents opted to do nothing (70.8%) than use biological control (0%), host plant resistance (25%), or other management tools (4.2%).
Aplastic Anaemia—A South African Context
Authors: Ramsamy Tyral Dean , Solomon Cleo Emma , Demetriou Georgia Savva 
Published: March 2022

Background: There is a paucity of data in South Africa documenting the various causes of aplastic anaemia (AA), as well as the response to immunosuppressive therapy.
Objective: To determine the absolute number of AA cases, possible causes and response to immunosuppressive therapy at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH).
Method: A retrospective cross-sectional analysis was conducted of all confirmed cases of AA at the CMJAH for the period of January 2014 to June 2019.
Results: There were 35 cases of AA for the given study period. Sixty-five percent of the study sample had no identifiable cause for AA and were defined as idiopathic. Twelve patients (34%) had identifiable secondary causes for AA; these included exposure to drugs and toxins, pregnancy, viral infection and auto-immune conditions. All patients were treated with combination immunosuppressive therapy. None of the patients had received a stem-cell transplant. Eighteen percent of patients had a complete response to therapy, 49% had a partial response whilst 29% were refractory to therapy. Four percent of patients relapsed after treatment.
Conclusion: AA is a rare disease with significant mortality. All possible secondary causes should be sought with a detailed patient history and relevant investigations. All patients must be treated with the recommended treatment protocol and exposure to offending drugs/toxins should be terminated. Every effort to improve patient follow-up should be made so as to establish concrete data on mortality and long-term complications.
An Audit of Blood Cultures in an Emergency Department at a Johannesburg Academic Hospital
Authors: Rae Bradley. , Gihwala Radha. , Bentley Alison. 
Published: March 2022

Background: Blood cultures (BCs) are the standard test for detecting bacteraemia but have come under scrutiny on their usefulness in the Emergency Departments (EDs) as they have a low yield, tend not to alter patient management and may be subject to high contamination rates especially in resource-limited settings. Identifying patients most at risk of bacteraemia may improve BCs’ usefulness.
Methods: We conducted a retrospective observational, descriptive and comparative study. Reports from all BCs performed in the ED at Helen Joseph Hospital in 2017 were requested from the National Health Laboratory Service. Data from all positive BCs were used to audit cultured organisms and their sensitivity and resistance patterns. Second, clinical and laboratory data from 206 consecutively selected patients (103 positive and 103 negative BC results) were used to calculate the Shapiro score and the Systemic Inflammatory Response Syndrome (SIRS) criteria as screening tools for sepsis.
Results: There was a total of 4011 BCs performed in 2017 of which 715 (17.8%) were positive. Pathogens were cultured in 400 (10.0%) of cases and 315 (7.9%) cultured known contaminants. A positive Shapiro score and SIRS criteria increased the likelihood of a positive BC by 5.6 and 2.3 times, respectively. Positive HIV status, rigors, pulse rate > 115 bpm, deranged mentation, white cells > 18 × 109 cells/L and creatinine > 177 μmol/L were risk factors for positive BCs.
Conclusion: There was a low yield of positive BCs from the ED, and using the SIRS criteria or the Shapiro score improves the pre-test probability of positive BC results in patients with suspected sepsis.
Mathematical modeling of the technological process and synthesis of the amidation control system
Authors: Buhaienko Ihor , Kyrylenko Maksym , Mylenkyi Volodymyr 
Published: March 2022

There is still no exact mathematical model or control system for sodium sulphacyl production, so not all available control systems are accurate and not all possible disturbances of the system during operation have been identified. An urgent problem is to create an optimal mathematical model and use it as the basis for the synthesis of an amidator control system using a controller.
In creating a mathematical model for the synthesis of the control system for the amidation process, it is necessary to understand the component of its mechanism. The amidation reaction takes place with a significant heat release, as well as through the available catalyst in the amidator, and side reactions occur. Using static and dynamic characteristics, a mathematical model was created, from which a control system was developed using a PID controller.
After a mathematical model has been developed, it becomes clear that the amidator must be cooled constantly for its correct operation, because the lower the temperature of the amide at the outlet, the better the product. The temperature must be maintained at a level of 324K to 327K with water supply for cooling at 19-20 kg/s. The implemented automatic process control allows the production capacity to be managed at minimal cost. The PID controller, which is configured according to the formula of the transfer function of the amidator and the transport delay link, was selected as the main controller. The controller used includes two components: integral and differential.
The synthesis of the control system based on the PID controller made it possible to fully investigate the process taking into account the disturbances, which were still uncertain, increased the rate of reaching a steady level, and reduced production costs.
Libre évolution et naturalité en forêt : définitions et métriques associées
Authors: Gosselin Frédéric , Génot Jean-Claude , Lachat Thibault 
Published: March 2022

Depuis son apparition dans la conservation de la nature, la notion de naturalité est très souvent employée pour les écosystèmes forestiers. La multitude de termes pour caractériser les forêts “naturelles” reflète la complexité de ce concept. Nous proposons dans cet article d’analyser les relations entre libre évolution et naturalité, et de distinguer les deux grands types de naturalité : biologique et anthropique — la naturalité anthropique comprenant la notion de libre évolution ou de spontanéité des processus. Nous proposons ensuite une synthèse des métriques employées dans la littérature scientifique pour mesurer ces deux types de naturalité en forêt. Les métriques liées à la naturalité biologique se focalisent sur les stades âgés et sénescents, celles concernant la naturalité anthropique sont plus centrées sur les prélèvements de bois passés (durée depuis la dernière exploitation, intensité des prélèvements…). Nous discutons enfin de ces notions considérées dans un contexte plus large — pas uniquement forestier ; cela nous amène à aborder les biais relatifs au choix des métriques, le lien entre biodiversité et naturalité, l’état de référence dans un contexte de changement global et la relation entre libre évolution et ré-ensauvagement.
« Que voit-on dans une forêt en libre évolution que l'on ne voit pas ailleurs ? », trois regards complémentaires
Authors: Garrigue Joseph , Larrieu Laurent , Boisson Bernard 
Published: March 2022

Le regard de Joseph Garrigue : chronique d’une observation naturaliste sensible. Le regard de Laurent Larrieu : des espaces forestiers en libre évolution : Pourquoi ? Où ? Comment ? Que dit la science ?
Outre leur grande valeur patrimoniale intrinsèque, les forêts faiblement anthropisées offrent un refuge à la biodiversité spécifique des milieux forestiers, jouent un rôle important dans l’atténuation des effets du changement climatique et servent d’observatoires pour mieux comprendre le fonctionnement des écosystèmes forestiers naturels ainsi que de références pour développer une gestion basée sur l’imitation des processus naturels. La mise en libre évolution sur le très long terme d’espaces forestiers vise à augmenter la proportion de forêts faiblement anthropisées. Cette revue de littérature précise les caractéristiques que devraient avoir ces espaces forestiers pour pleinement jouer le rôle qui leur est assigné. Bien que les connaissances scientifiques sur le sujet soient encore fragmentaires, nous pensons qu’elles sont à ce jour suffisantes pour optimiser les initiatives de mise en place de surfaces en libre évolution par les gestionnaires de forêts.
Le regard de Bernard Boisson : les forêts rendues à l'oubli pluriséculaire comme référentiels pour recentrer le progrès et réaccorder la société
Les forêts en libre évolution ont une valeur de référentiel perceptuel pour inspirer et recentrer différemment toute gestion territoriale du plus rural au plus urbain. Cette prise de conscience nécessite l’inclusion de domaines de connaissances inhérents aux sciences humaines et aux approches culturelles sensibles en sachant que seule une humanité régulée est compatible avec une nature régulée et que cela implique la plus grande maturité interdisciplinaire entre nous tous. La nature non-domestiquée réveille l’humain inconditionné. Face à un mal-être social latent dans les paysages artificiels : « le déracinement humain dans des lieux déracinés », cette prise de conscience se révèle en grand antidote.
Upaya Membentuk Keluarga Sakīnah pada Keluarga Penghafal Alquran
Authors: Muna Muzalifatul , Munir Moh. 
Published: March 2022

The memorization of the Qur'an that has a family, of course, becomes increasingly mandatory, namely taking care of the family well and maintaining memorization. It happened to the four families memorizing the Qur'an in the village of Nglewan. Their activities are often preoccupied with practicing the Qur'an to make their obligation to take care of the family to be not maximal. The purpose of this study is to explore how the fulfillment of the rights and obligations of the husband and wife in the family of memorization of the Qur'an and how efforts to solve problems in the family of memorization of the Qur'an in the village of Nglewan Ponorogo. This research used qualitative descriptive approaches and interviews and observations to collect data. Based on the results of this study can be concluded, First, the fulfillment of the rights and obligations of the husband and wife to the family of memorization of the Qur'an in Nglewan Village as a whole is by Islamic law. Because of the fact on the ground, husband and wife have tried to carry out their obligations even though their application is still less than optimal. They also must keep the Qur'an. Second, efforts to solve problems with the family of memorization of the Qur'an in Nglewan Village as a whole have been applied by Islamic law. Because of the effort to resolve it using deliberation and to advise each other until they make peace.
Bagi penghafal Alquran yang sudah berkeluarga tentu menjadi bertambah kewajibannya, yaitu mengurus keluarga dengan baik dan menjaga hafalan. Sebagaimana terjadi pada keempat keluarga penghafal Alquran di Desa Nglewan. Aktifitas mereka yang kerap kali disibukkan dengan mengamalkaan Qur’an sehingga menjadikan kewajibannya mengurus keluarga menjadi tidak maksimal. Tujuan penelitian ini untuk menggali bagaimana pemenuhan hak dan kewajiban suami istri pada keluarga penghafal Alquran dan bagaimana upaya penyelesaian problematika pada keluarga penghafal Alquran di Desa Nglewan Ponorogo. Dengan menggunakan pendekatan deskriptif kualitatif dan wawancara maupun observasi, sebagai metode pengumpulan data. Berdasarkan hasil penelitian ini dapat disimpulkan, Pertama, pemenuhan hak dan kewajiban suami istri pada keluarga penghafal Alquran di Desa Nglewan secara keseluruhan sudah sesuai dengan hukum Islam. Karena fakta dilapangan suami dan istri sudah berusaha untuk melaksanakan kewajibannya meskipun dalam penerapannya masih kurang maksimal. Dikarenakan mereka juga mempunyai kewajiban untuk menjaga hafalan Alquran. Kedua, upaya penyelesaian problematika pada keluarga penghafal Alquran di Desa Nglewan secara keseluruhan sudah diterapkan sesuai dengan hukum Islam. Karena upaya untuk menyelesaikannya dengan cara musyawarah dan dengan saling menasehati hingga mereka berdamai.
Geographic Atrophy After Reabsorption of Pigment Epithelial Detachment (GARPED) Study
Authors: Peng Enoch , Adrean Sean D 
Published: March 2022

Abstract
Background: To describe the occurrence, rate of geographic atrophy (GA) expansion, and changes in visual acuity (VA) after reabsorption of subfoveal pigment epithelial detachments (PED).Methods: Included patients had reabsorption of a PED followed by GA. Patients underwent clinical examination with SD-OCT. Images were classified by size with grading occurring post reabsorption. VA was recorded pre reabsorption, post, and over time.Results: The average age of the cohort, consisting of 22 eyes from 19 participants, was 86.9 years at reabsorption. Prior to reabsorption, the VA was 20/80 and then declined to 20/200 (p=0.001). There was no significant VA change after the initial loss with reabsorption. The average initial lesion size of GA was 0.987 mm2 with an average growth rate of 0.274 mm/year.Conclusions: This study longitudinally examined GA growth rate in patients with reabsorbed PEDs. These patients started with a drusenoid or serous PED, had a dramatic reduction in vision and GA that occurred in place of the PED. These GA lesions have a slower growth rate and a smaller area of onset. They do not show significant VA change after reabsorption. As we enter the era of potential GA therapy, these patients may not benefit from current treatments under investigation.
Comparison of the performance of the UV/ZrO2 and UV/H2O2/ZrO2 photocatalytic oxidation processes in the aqueous phase degradation of ethidium bromide
Authors: Samarghandi Mohammad Reza , Rashtbari Yousef , Ghotekar Suresh , Ahmadi Shabnam , Igwegbe Chinenye Adaobi , Ghosh Soumya , poureshgh yousef , Rahmani Zahra 
Published: March 2022

Abstract
Ethidium bromide reaches the receiving waters and threatens the aquatic ecosystems due to its wider usage in biological laboratories. In the present work, ZrO2 NPs (a photocatalyst) was selected for the photocatalytic removal of EtBr using UV/ZrO2, and UV/H2O2/ZrO2 processes. The effects of working parameters including pH (2-10), contact time (5, 10, 20, 30, 45, and 60 min), dosage of ZrO2 NPs (0.1-1.0 g/L), initial EtBr concentration (1, 10, 25, 50, and 100 mgL−1), and H2O2 concentration (0.1, 0.25, 0.5, 0.75, and 1.0 ml/L) on the photocatalytic degradation of EtBr were investigated at 25±2°C. The photocatalytic degradation kinetic parameters were evaluated via the pseudo-first-order model. Finally, the COD was determined to estimate the organic pollutant reduction capability of the processes used in this research. The UV/H2O2/ZrO2 (100%) was more effectual than the UV/ZrO2process (94%) at pH: 8, ZrO2: 0.5g/L, and H2O2: 0.5 ml/L, EtBr concentration: 50 mg/Land 60 min; which gave COD removals of 71.3and 30.7%, respectively. The UV/H2O2/ZrO2 kinetics data followed the pseudo-first-order rate reaction. As a result, photocatalysis process is a useful method for removing EtBr since 100% EtBr reduction was observed using the UV/H2O2/ZrO2 process.
Molecular Characterization of ESR1 Variants in Breast Cancer
Authors: Heeke Arielle L , Elliott Andrew , Feldman Rebecca , O'Connor Hazel F , Pohlmann Paula R , Lynce Filipa , Swain Sandra M , Nunes Maria R , Magee Daniel , Oberley Matthew J , Swenson Jeffrey , Vidal Gregory , Isaacs Claudine , Schwartzberg Lee , Korn W Michael , Tan Antoinette R 
Published: March 2022

Abstract
Purpose:Estrogen receptor 1 (ESR1) mutations and fusions typically arise in patients with hormone receptor-positive breast cancer after aromatase inhibitor therapy, whereby ESR1 is constitutively activated in a ligand-independent manner. These variants can impact treatment response. Herein, we characterize ESR1 variants among molecularly profiled breast cancers.Methods:DNA next-generation sequencing (592-gene panel) data from 9860 breast cancer samples were retrospectively reviewed. Gene fusions were detected using the ArcherDx fusion assay or whole transcriptome sequencing (N = 344 and N = 4305, respectively). Statistical analyses included Chi-square and Fisher’s exact tests.Results:An ESR1 ligand binding domain (LBD) mutation was detected in 8.6% of tumors evaluated and a pathogenic ESR1 fusion was detected in 1.6%. The majority of ESR1 LBD mutations/fusions were from estrogen receptor (ER)-positive samples (20.1% and 4.9%, respectively). The most common ESR1 LBD mutations included D538G (3.3%), Y537S (2.3%), and E380Q (1.1%) mutations. Among biopsy sites, ESR1 LBD mutations were most observed in liver metastases. Pathogenic ESR1 fusions were identified in 76 samples (1.6%) with 40 unique fusion partners. ESR1 variant (mutation/fusion) samples more frequently expressed androgen receptor (78.0% vs 58.6, p<0.0001) and less frequently immune checkpoint proteins than ESR1 wild-type (PD-1 20.0% vs 53.4, p<0.05; immune cell PD-L1 10.0% vs 30.2, p<0.0001).Conclusion:We have described one of the largest series of ESR1 fusions reported. ESR1 LBD mutations were commonly identified in ER-positive disease. Limited data exists regarding the clinical impact of ESR1 fusions, which could be an area for future therapeutic exploration.