bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world Utilization of the 21-gene Assay in Taiwanese Female Patients with Early-stage Breast Cancer
Authors: Huang Yi-Ching , Kuo Yao-Lung , Lee Kuo-Ting , Hsu Hui-Ping , Loh Zhu-Jun , Tsai Jui-Hung , Yang Shuen-Ru , Lee Chun-Hui , Chen Shang-Hung , Chung Wei-Pang 
Published: September 2022

Background:
Clinical trials have demonstrated that the 21-gene assay (Oncotype DX) can predict the benefits of adjuvant chemotherapy in patients with hormone receptor-positive (HR+) and human epidermal growth factor 2-negative (HER2−) breast cancer. This study investigated the real-world utilization of this genomic test in Taiwanese patients.

Materials and Methods:
We compiled data on the recurrence score (RS) and clinicopathological characteristics of patients who received the 21-gene assay between August 2016 and August 2021. Survival outcomes were analyzed using the Kaplan–Meier method and log-rank test. Correlations between clinicopathological characteristics and RSs were analyzed using the Chi-square test or Fisher's exact test.

Results:
Of the 106 recruited patients, 34 and 72 were classified into different risk groups using conventional and Trial Assigning Individualized Options for Treatment (TAILORx)-based cutoff points, respectively. In the conventional stratification group, 61.8%, 29.4%, and 8.8% of the patients were classified into the low-risk (RS: 0–17), intermediate-risk (RS: 18–30), and high-risk (RS: 31–100) categories, respectively. In the TAILORx stratification group, 18.1%, 72.2%, and 9.7% of the patients were classified into the low-risk (RS: 0–10), intermediate-risk (RS: 11–25), and high-risk (RS: 26–100) categories, respectively. In survival analysis, recurrence-free survival did not significantly differ among discrete risk categories. The high-risk category determined using TAILORx-based cutoff points was associated with the presence of >14% Ki-67-positive cells (P = 0.004) and tumor histology Grade III (P = 0.001).

Conclusion:
Using the Oncotype DX assay, we classified a small proportion of our Taiwanese patients into the high-risk category; no survival difference was observed among the patients in distinct risk categories. These results suggest the clinical utility of the 21-gene assay in Taiwanese patients with early HR+/HER2−breast cancer.
Ophthalmological practices in COVID pandemic during first and second wave
Authors: Singh Vivek , Anand Abhishek , Kumar Vidya Bhushan , Eqbal Shadma , Raj Pragati 
Published: September 2022

Purpose:
TO study the impact of covid 19 in a tertiary eye care hospital.

Study type:
single centre retrospective observational study.

Method:
Novel corona virus “COVID-19” is now an established global Pandemic. Index case of Novel Corona virus “COVID-19” virus was first reported from Wuhan, People's Republic of China on 31 December 2019. Bihar with a population of 120 million is one of the most densely populated and least developed states in India. With 1 doctor/29,000 persons and1 hospital bed/8,645 people, it was expected to be one of the worst hit state in COVID-19 pandemic. All patient visiting an ophthalmologist were seen with full precaution and with a practical Standard Operating Protocol (SOP), advised by World Health Organization (WHO), Centre for disease control (CDC), MOHFW, American Academy Of Ophthalmology(AAO) and All India Ophthalmological Society(AIOS). Patient visiting and treatment protocol followed in a tertiary care hospital were analysed.

Results:
3617(2432 males, 1185 females) new patients and 3145(2149 males, 996 females) old/follow up patients visited RIO OPD from lockdown (25 march 2020) till unlock 4(30 September, 2020) which is about 85.41% decrement in comparison to last year in same period 21747(13335 males, 8412 females) new patients and 24610(15508 males, 9102 females).

Conclusion:
Proper use of n95 masks, gloves, caps, face shield, PPE kit while examining patients and operating them were few important precautions. Regular use of sanitizer, hand washing, minimizing patient doctor contact time, minimal hospital stays, use of artificial intelligence are few other ways practiced to prevent exposure to COVID 19. This pandemic has taught us a lot about people unity cooperation, what is important in life, ophthalmologically tele-ophthalmology will play a big role in future an evident in this pandemic.
Ten Years' Follow-up for Cemented Hip Arthroplasty in Patients <60 Years of Age with Standardization of Cementing Technique
Authors: Sajid Imran , Jameel Javed , Singh Sukhvinder , Singh Surya Pratap , Varshney Ankit , Ahmad Sabeel 
Published: September 2022

Introduction:
Total hip arthroplasty (THA) is the preferred treatment for persistent disability due to hip pathologies and restoration of normal functions. Although there is a general consensus of using un-cemented implants for adults and elderly with good bone quality and cemented for senior citizen population, implant choice for middle aged group of 40 years to 60 years is still a subject of debate, especially in financial constrained situations. In our study, we have determined the implant survivorship and functional outcomes of cemented THA in patients between 40 and 60 years of age, at the minimum follow-up of 10 years with emphasis on standardization of cementing technique.

Materials and Methods:
This is a retrospective study including 25 patients who had undergone cemented hip arthroplasty. Data were collected from five different surgical centres, whose orthopedic surgeons had common surgical training and were following a common cementing technique.

Results:
Mean Harris Hip Score of 25 hips at final follow-up was 90 and Visual Analog Scale 1.88. The functional outcome was good to excellent at final follow-up in 89% hips. There was a significant improvement in pain and activity level after surgery (P < 0.001) and maintained at the final follow-up.

Conclusion:
Our series provides evidence for utility of cemented hip implants in low functional demand patients along with emphasizing the importance of a good cementing technique for the long-term survival of cemented hip arthroplasty in the age group of 40–60 years.
Posteromedial Tibial Plateau Fractures – Functional Outcome of Posteromedial Buttress Plating with Precontoured Locking Plate Using Modified Lobenhoffer Approach
Authors: Unnikrishnan J. , Chandan Kumar , Bindulal V. A. 
Published: September 2022

Posterior tibial plateau fractures have a complex intra-articular fracture pattern, representing approximately 1.2% of all fractures. The occurrence of the posteromedial shear fragment is relatively common in high-energy tibial plateau fractures.

Aims and Objectives:
To study the role of posteromedial plating in the management of complex tibial plateau fractures with a posteromedial fragment.

Materials and Methods:
Only patients with posteromedial fracture patterns alone are taken into account. Twenty cases above 20 years of age, from the patient, admitted to Government Medical College, Thrissur, with posteromedial fragment in tibial plateau fractures that were operated were undertaken for the study. The patients were followed up for 2 years.

Results:
Of the 20 patients with posteromedial tibial plateau fractures from X-ray and computed tomography scan of the knee joint, all patients were treated with precontoured posteromedial buttress plating using single anatomical locking plate. We analyzed patients with Rasmussen scoring postoperatively. In our analysis, among 20 patients, the functional score was excellent in 14, good in 5, fair in 1, and poor in none. There was one patient with compartment syndrome who had developed a mild surgical site infection that later resolved. No excessive collapse is seen postoperatively since locked plate is used. Four patients had transient paraesthesia of the saphenous nerve; both resolved completely.
Prescribing pattern for acute diarrhea in children
Authors: Patra Vikram S. , Gavhane Jeetendra B. , Amonkar Priyanka S. 
Published: September 2022

Context:
Irrational use of medications for acute diarrhea in children is rampant. We conducted this survey to analyze prescription practices among pediatricians for acute diarrhea and their deviation from standard treatment guidelines.

Subjects and Methods:
A self-administered online questionnaire regarding prescription practices was circulated among pediatricians in Maharashtra, India, through various academic groups on WhatsApp, during the World Oral Rehydration Salt (ORS) Week, 2021. The questionnaire was anonymous and consisted of 15 compulsory close-ended multiple-choice questions.

Results:
Two hundred and eighty-seven pediatricians participated. Among which, 88.9% of the participants said that they prescribed ORS in acute diarrhea, 26.8% preferred zinc supplementation only in the case of watery diarrhea, 62% used probiotics or probiotics plus zinc combinations, and 60% said that they prescribe antisecretory drugs such as racecadotril. Forty percentage of the participants admitted that they occasionally use antibiotics for the management of acute diarrhea, while 5% said that they frequently do so. Most pediatricians advise appropriate ORS substitutes. Large number of pediatricians perceived probiotics (51.2%), dietary restriction (15.7%), racecadotril (10.5%), and antibiotics (6.3%) to be an important part in managing acute diarrhea. Only 25.4% of the pediatricians answered correctly and said parental counseling along with zinc and ORS work best as treatment.

Conclusions:
This study demonstrates low adherence by pediatricians to standard treatment guidelines for the management of acute diarrhea. Misuse of antibiotics and unscientific use of drugs were evidenced from this study. Awareness regarding the advantages of ORS among pediatricians is high. At present, there is a need to focus on appropriate feeding practices, emphasizing on the role of zinc and discouraging use of antibiotics, probiotics, antisecretory drugs, and irrational combinations.
Traditional Cuisine of the Nekrasov Cossacks
Authors: Vlaskina Tatyana Yu. 
Published: September 2022

The article is a comparative historical cross-cultural study of the traditional cuisine of the Nekrasov Cossacks – a group of Russian Old Believers known for their rich migration experience. Since the basis of the food system is fish, Nekrasovite’s cuisine has many fish dishes, and at the same time the high status of cereal dishes remains. In the recipe and methods of preparation, the preservation of old Russian traditions is noticeable. In supplements to the main ration, one can see the influence of South European and Turkic cultures.
The purpose of this study is to identify the marking qualities of culinary traditions in the field of the historical dynamics of the cultural identity of the Nekrasov community.
The study shows that in the field of culinary traditions, numerous evidences of the historical path of this unique ethnosocial group have been accumulated. Despite the relative preservation of the ritual sphere, in the everyday and festive cooking of the Nekrasov Cossacks, multiple borrowings from the Danube and Mediterranean cuisine associated with complex processes of discrete inculturation have been revealed. New borrowings in the central zone of culture are explained by the fact that, with multiple migrations, it becomes more and more difficult for migrants to differentiate “their own” and “foreign” in such minute details as required by tradition, since in addition to the main cultural and genetic metropolis, a certain set of places of origin is formed in their minds.
Caspian Elite Consensus: a Pact of Integration in a Globalizing World
Authors: Markelov Konstantin A. , Karabushenko Pavel L. , Usmanov Rafik Kh. , Velikaia Sabina A. 
Published: September 2022

Contemporary activities in the geopolitical space including the countries of the Caspian Sea Basin and its adjacent regions give relevance to the problem under study. Globalism has an impact on the development of regional processes, making adjustments in their course. This article aims to analyze the consensus achieved by the political leaders of the Caspian states regarding their integration. The leading approach in the research explores the position of modern Russian elitology, taking professional elites to be a synergetic system striving for the acmeological pinnacle of their (elites’) competence. This approach helps to find out the adequacy of their professional activities, the objectivity of their assessments of reality, and the impact of their political decisions. Comparative analysis has made it possible to identify the points of convergence, while the use of political conflictology techniques has made it possible to identify and curb the emergence of threats in a timely manner. The combination of such methods and approaches enhances the objectivity of conclusions and assessments of the Caspian leaders’ actions.
The paper analyses the activities of regional political elites who created a political and legal platform for a new stage of constructive development of dialogue between cultures and socio-economic cooperation. It is noted that this process had a complex gradual nature of harmonizing different positions, compromises and smoothing over the contradictions of national interests. In this process, the Caspian countries have demonstrated genuine tolerance, political correctness and democracy in addressing the complex geopolitical challenges and reaffirmed their desire to resolve existing problems in a peaceful manner. The materials of this paper may prove useful for the development of further integration strategies, as well as for the expert support of the critical decisions on security issues and the formation of independent regional financial, political and cultural systems.
ГИБКИЕ ТЕХНОЛОГИИ ПРИ РАЗРАБОТКЕ
ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ В ОБЛАСТИ
ПОЖАРНОЙ БЕЗОПАСНОСТИ
Authors: Станкевич Т.С. , Мищук Б.Р 
Published: September 2022

Проведен обзор Agile-методов и практик на 2021 г. Установлено, что наблюдается
положительная динамика внедрения в управленческие процессы предприятий гибких
технологий. Эпидемия коронавирусной инфекции COVID-19 и переход на дистанционную
работу для многочисленных команд из различных сфер инициировали активизацию
внедрения гибких технологий. Выполнен SWOT-анализ для выявления достоинств и
недостатков технологий Agile. Выбран оптимальный метод гибких технологий для
управления процессом разработки программного обеспечения в области пожарной
безопасности. В качестве метода, обеспечивающего максимизацию эффективности
разработки проекта в области цифровых систем для безопасности производственного
объекта, выбран Hybrid method (scrum + waterfall).
ГЕОЭКОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА СИСТЕМЫ
РЕКА СВЕТЛОГОРКА-ПРУД ТИХИЙ ПО НАБЛЮДЕНИЯМ
2019-2021 ГГ.
Authors: Алферов В. О. , Цветкова Н. Н. 
Published: September 2022

В статье представлены результаты геоэкологических исследований нижнего
течения реки Светлогорки и образованного на ней пруда Тихого в пределах городакурорта Светлогорска на территории Калининградской области. На основе качества воды
и соответствия гидрохимических параметров водных объектов действующим нормативам
дана оценка современного состояния пруда и реки.
ИНТЕГРАЦИЯ 3D-МОДЕЛЕЙ В СИСТЕМЫ
УПРАВЛЕНИЯ ИНЖИНЕРНЫМИ ДАННЫМИ
Authors: Арсентьев И. Е , Соловей М. В. 
Published: September 2022

Целью данной статьи является изучение проблем и нахождение способов решения
некоторых задач интеграции 3D-моделей в систему управления инженерными данными,
посредством оптимизации задач и разработкой новых алгоритмов.
ASSESSING THE CULTURAL AND HISTORICAL
POTENTIAL OF THE VOLGOGRAD REGION
Authors: Udoenko K. O. 
Published: September 2022

This article focuses on the peculiarities of the cultural and historical potential of the Volgograd
region. The analysis of regional potential, the use of the data obtained to form tourist brands and their
further promotion both domestically and internationally are important components in the
development of tourism. The research was based on a parametric method, to get a representative
result. After obtaining necessary data, we concluded that the most advanced administrative-territorial
unit, in terms of cultural and historical potential, is the regional capital Volgograd. Municipal districts
have a lower indicator, which is directly linked to deficiencies in a statistical recording system, a
management system, a marketing system of promotion of regional tourism products and etc. The idea
of cross-regional cooperation between the Volgograd and Rostov regions in the field of tourism
potential development was proposed.
МОНИТОРИНГОВЫЕ ИССЛЕДОВАНИЯ РАЗВИТИЯ
ИНФЕКЦИОННЫХ БОЛЕЗНЕЙ РАСТЕНИЙ В АГРОЦЕНОЗЕ
ОЗИМОЙ ПШЕНИЦЫ (Triticum aestivum L.)
Authors: Макарова А. Н. , Григорович Л. М. 
Published: September 2022

В статье представлены результаты проведения мониторинговых исследований
развития инфекционных болезней растений озимой пшеницы. Установлено, что
доминирующими болезнями в агроценозе озимой пшеницы являются: ризоктониозная
корневая гниль (Rhizoctonia solani J.G. Kuhn.), пиренофороз пшеницы, или желтая
пятнистость (Pyrenophora tritici-repentis Died), мучнистая роса (Erysiphe graminis DC),
септориоз листьев и колоса (Septoria tritici Rob et Desm и Septoria nodorum Berk.), чернь
колоса (грибы из рода Alternaria), фузариоз колоса (возбудители - виды грибов рода
Fusarium). Проведен расчет потенциальных потерь урожая зерна в результате поражения
доминирующими болезнями, суммарные потери составили 65960 руб./га. На основании
установленной динамики развития болезней спрогнозированы сроки двукратных
фунгицидных обработок: опрыскивание посева в стадию развития растений ЕС 30 (выход в
трубку) осуществлено фунгицидом Альто-Турбо (действующие вещества пропиконазол и
ципроконазол) с нормой расхода препарата 0,3 л/га; в стадию ЕС 60 (цветение) фунгицидом
Прозаро (пропиконазол и тебуконазол) с нормой расхода 0,8 л/га.
Co-Infection Status of Enterovirus among Hepatitis (A, B, and C) Positive Individual Living within Abuja Internally Displaced Persons Camps
Authors: Fadason, D. T  , Aliyu, A. M  , Musa, J.  
Published: September 2022

The Enterovirus (EV-71) co-infection among Hepatitis A, B and C virus has become a global co-mortality. This research determined enteroviruses (EV-71) co-infection profile among HAV, HBV and HCV positive individuals within internally displaced persons camps Abuja, Nigeria. A descriptive cross sectional research design was adopted where blood samples from 450 respondents were collected within the three camps and screened for the presence of Hepatitis A, B and C. Positive samples were further assayed for co-infection with Enterovirus-71 using Rapid Strip RT-PCR Amplification of 16sRNA for Enterovirus 71(EV71). The data were analyzed using the SPSS Version 22.1 Software. The results revealed that out of the 450 studied subjects 11 (2.4%) were HAV positive, 42 (9.3%) were HBV positive and 33 (7.3%) were HCV positive. Only 1 (0.2%) subject was found to be co-infected with HAV/EV-71. The prevalence of hepatitis among the studied subjects was found to differ significantly among males and females (P=0.001), among various age groups (P=0.001) and among various occupation (P=0.001). The study reports low rate of Enterovirus-71 among hepatitis (A, B, and C) positive individuals living within Abuja internally displaced persons camps. The study recommends routine screening of internally displaced individuals for the presence of hepatitis virus and EV-71 for early diagnosis and possible adoption of management and control measures that may include vaccination of infected individuals.
EFFECT OF MARKETING CHANNELS ON ACCOUNTS RECEIVABLES MANAGEMENT IN THE HOTEL INDUSTRY IN KENYA
Authors: Ngugi Simon K. , Gakure Prof. Roselyn W. , Gekara Dr. Geoffrey M , Kahiri Dr. James K. 
Published: September 2022

Purpose: The purpose of the study was to establish the effects of marketing channels in accounts receivables management in the hotel industry in Kenya.Methodology: The target population of the study was 47 hotels and lodges in Kenya. A sample of 141 respondents was selected using stratified random sampling in each hotel and lodge to group respondents into three strata. The strata were that of top management, finance staff and credit control staff. This study used both primary and secondary data. Data collection methods used included: questionnaires and secondary data collection guide. Secondary data was collected for all variables for a period of three years (2007 to 2010). Information was sorted, coded and input into the statistical package for social sciences (SPSS) for production of graphs, tables, descriptive statistics and inferential statistics. In particular, means, standard deviations, and frequencies. Inferential statistics such as factor analysis and odd ratio regression were also used. Results: Based on the findings, the study concluded that marketing channels had a positive effect on accounts receivables management. It can therefore be concluded that competition was the major reason for granting trade credit in hotels and receivables help in attracting potential customers and retaining the older ones at the same time by weaning them away from the competitors.Unique contribution to theory, practice and policy: Based on the findings, the study recommends that the hotel management should ensure that staff offers high quality of service so as to attract and retain their customers.
INFLUENCE OF POLICIES ON ACCOUNTS RECEIVABLES MANAGEMENT IN THE HOTEL INDUSTRY IN KENYA
Authors: Ngugi Simon K. , Gakure Prof. Roselyn W. , Gekara Dr. Geoffrey M , Kahiri Dr. James K. 
Published: September 2022

Purpose: The purpose of the study was to determine the influence of policies on accounts receivables management in the hotel industry in Kenya.Methodology: The target population of the study was 47 hotels and lodges in Kenya. A sample of 141 respondents was selected using stratified random sampling in each hotel and lodge to group respondents into three strata. The strata were that of top management, finance staff and credit control staff. This study used both primary and secondary data. Data collection methods used included: questionnaires and secondary data collection guide. Secondary data was collected for all variables for a period of three years (2007 to 2010). Data was analyzed quantitatively and presented descriptively and illustrated by use of tables and charts. Information was sorted, coded and input into the statistical package for social sciences (SPSS) for production of graphs, tables, descriptive statistics and inferential statistics. In particular, means, standard deviations, and frequencies. Inferential statistics such as factor analysis and odd ratio regression were also used. Results: Based on the findings, the study concluded that management policies are a key driver to accounts receivables management in hotel industry in Kenya. It was possible to conclude that the hotels had put into place strict management policies and internal operating procedures approved by the senior management on accounts receivables.Unique contribution to theory, practice and policy: Based on the findings, the study recommends that that hotel management should ensure that they employ workers who can follow orders with minimum supervision and reward them well in terms of compensation to avoid cases of theft, complaints from customers and endorse a heavy penalty for any employee who provide substandard service.