bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene Expression Responses in Bronchial Epithelial Cells Exposed to Vanadium
Authors: Li Xiaofeng , Abdel-Moneim Abdel-Moneim Eid , Yang Bing 
Published: June 2022

Abstract
Vanadium exposure has the negative effect on lung health in human, whereas the detailed mechanisms of vanadium exposure-induced pulmonary toxicity are limited. Hence, the present study aimed to investigate the hub genes and signaling pathways related to sodium metavanadate (SMV)-induced pulmonary toxicity. The transcript expression profile GSE36684 was downloaded from Gene Expression Omnibus. The profile contained eight human bronchial epithelial cell (HBEC) samples including five SMV-treated and three control HBECs samples. Totally 455 differentially expressed genes (DEGs) were screened, especially 201 and 254 genes were up- and down-regulated in the HBECs treated with SMV. Gene ontology analysis suggested that the DEGs were mainly involved in signal transduction, the response to drug, cell proliferation, adhesion and migration. Pathway analysis demonstrated the DEGs were primarily participated in NF-κB, Wnt, MAPK, and PI3K-Akt signaling pathways. Moreover, the hub genes, including ITGA5, ITGB3, ITGA2, LAMC2, MMP2, and ITGA4, might contribute to SMV-induced pulmonary toxicity. Our study improves the understanding of the molecular mechanisms by which SMV induced the pulmonary toxicity.
Digital twin-based life-cycle seismic performance assessment of a long-span cable-stayed bridge
Authors: Lin Kaiqi , Xu You-Lin , Lu Xinzheng , Guan Zhongguo , Li Jianzhong 
Published: June 2022

Abstract
Long-span cable-stayed bridges often have a design service life of more than a hundred years, during which they may experience multiple earthquake events and accumulate seismic damage if they are located in seismic-prone regions. Earthquake occurrence is discretely and randomly distributed over the life cycle of a long-span cable-stayed bridge and often causes sudden drops in the structural performance instead of yearly fixed seismic performance degradation. This study thus proposes a digital twin-based life-cycle seismic performance assessment method for long-span cable-stayed bridges. The major components of this method include: (1) a seismic hazard analysis-based generation method of earthquake occurrence sequence; (2) a digital twin-based structural response prediction method considering lifetime earthquake occurrence and sequence; and (3) a service life quantification method. The proposed method is applied to a scaled long-span cable-stayed bridge with a series of shake table tests. The results show that the digital twin can closely reproduce the life-cycle seismic response of the bridge under sequential earthquakes. The proposed assessment method provides a more intuitive presentation of the life-cycle seismic damage accumulation process and a more accurate estimation of the service life of a long-span cable-stayed bridge.
Impact of Differencing and Averaging on Stationary Reliability Predictions
Authors: Yucesan Ongun 
Published: June 2022

Abstract
The series in economics or financial operations are time to time augmented to identify for a hidden character. Such manipulations are based on equal addition or subtraction on both sides of an auto regression formula accepted that the series are generated with. But, how useful these new ones be? Accepting an underlying hidden character, would an additional effort be needed? This paper tries to identify the impact of Dif-ferencing and Bi-sample mean operation on reliability observations series. Such an observations series is collected with a target to identify the probability of a failure for a period of active operation. From the tested manipulations , the differencing seems to be alleviating the trend and seasonality to a degree but shifting signal to heteroscedasticity. The bi-sample averaging is observed to be producing rather a negative impact. Therefore, if a series for reliability predictions depending upon interventions of this sort is at hand, then additional considerations could be convenient.
Robot Navigation in Crowd via DeepReinforcement Learning
Authors: lin Yixian , Song Shibo , Yao Junfeng , Chen Qingqing , Zheng Liling 
Published: June 2022

Abstract
The proposed method is to solve the robot navigation problem ina crowded environment. The complexity of navigation in the crowdincreases with the number of people. With the increase of the numberof pedestrians in the crowd, the success rate of the existing methodsis very low. Recent research shows that deep reinforcement learninghas good solving ability in solving continuous decision-making problemssuch as navigation.Therefore, a solution based on deep reinforcementlearning is proposed to solve the robot navigation in the crowd. First,the global environment map is created as the robot-centered crowd motion model, to represent the overall characteristics of the crowdenvironment. Second, the relative importance of each person in thecrowd is learned by combining the interaction pair of the robot andeach individual in the crowd and the overall crowd represented by theglobal environment map, and the people with high importance are con-cerned, the people with low importance are ignored, making the robotpay attention to the individual who has a great impact on navigationand realizing the efficient movement of the robot in the crowd, so asto reduce the complexity of the problem. Experiments show that themethod provided improves the success rate and efficiency of navigation.
Diagnosis of Parkinson’s Disease Using EEG and fMRI
Authors: Jiji Wiselin , Rajesh A. , Lakshmi M.Maha 
Published: June 2022

Abstract
Parkinson's disease is a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. Parkinson's symptoms usually begin gradually and get worse over time. As the disease progresses, people may have difficulty walking and talking. In this system, an Architecture is proposed for Parkinson’s disease detection by investigating the topological properties of functional brain networks within fMRI and EEG Signals of Healthy Control (normal) and PD patients. For fMRI the functional whole-brain connectome was constructed by thresholding partial correlation matrices of 160 regions from Dosenbach brain atlas. 160 x 160 functional correlation matrix was constructed using the Pearson correlation. From the graph theory approach, network metrics were analysed. For EEG spatial and Bispectrum features are extracted. Finally, Adaboost Classifier is used to classify whether it is normal or PD.
Partizipation und Kooperation
Authors: Brück-Hübner Annika 
Published: June 2022

In der schulpädagogischen Diskussion wird immer wieder auf das Potenzial von E-Portfolios als «Entwicklungsinstrument einer neuen Lernkultur» verwiesen. Häufig bleibt dabei jedoch unklar, was genau unter der «neuen Lernkultur» zu verstehen ist, und auch die empirische Evidenz steht bezüglich vieler Aspekte noch aus. In diesem Beitrag wird ein Modell der ‹neuen Lernkultur› vorgestellt. Anhand der Teilaspekte ‹Partizipation› und ‹Kooperation› wird anschliessend die theoretische Diskussion über das Potenzial von E-Portfolios als Schulentwicklungsinstrument exemplarisch skizziert. Zur Überprüfung der theoretischen Annahmen wurde im Jahr 2016 eine systematische qualitative Fallstudie mit sechs Lehrpersonen durchgeführt, die E-Portfolios im Unterricht der Sekundarstufe I/II einsetzen. Die Ergebnisse verdeutlichen eine grosse Diskrepanz zwischen theoretischem Anspruch und beobachteter Praxis. Basierend auf den Studienerkenntnissen gilt es die Chancen und Grenzen von E-Portfolios als Entwicklungsinstrument einer neuen Lernkultur zu diskutieren.
Zircon geochronological and geochemical insights into pluton building and volcanic-hypabyssal-plutonic connections: Oki-Dōzen, Sea of Japan—A complex intraplate alkaline volcano
Authors: Scarrow Jane H. , Chamberlain Katy J. , Montero Pilar , Horstwood Matthew S.A. , Kimura Jun-Ichi , Tamura Yoshihiko , Chang Qing , Barclay Jenni 
Published: June 2022

Abstract
The relationship between plutonic and volcanic components of magmatic plumbing systems continues to be a question of intense debate. The Oki-Dōzen Islands, Sea of Japan, preserve outcrops of temporally associated plutonic, hypabyssal, and volcanic rocks. Post-intrusion uplift juxtaposed Miocene syenites in inferred faulted contact with volcanic trachytes that are cut by rhyolite hypabyssal dikes. This provides a window deep into the timing and origins of magma storage architecture and dynamics. Zircon is ubiquitous in all samples; our aim is to determine what its age and composition can reveal about the plutonic-volcanic connection. Here we show magma source characteristics are recorded in zircon Hf isotopes; source composition and assimilation of heterogeneous hydrothermally altered crust in zircon O isotopes; and extensive fractional crystallization in zircon trace elements. Combined with new UTh-Pb SHRIMP zircon ages, 6.4–5.7 Ma, compositional data show pluton formation was by protracted amalgamation of discrete magma pulses. The rhyolite dike preserves an evolved fraction segregated from these discrete magmas. Synchronous with plutonism was a volcanic eruption of trachyte magma derived from the same source, which may have stalled at a relatively shallow depth prior to eruption. Stalling occurred at least above the amphibole stability zone because amphibole-compatible Sc and Ti were not depleted in the trachyte melt resulting in elevated values of these in volcanic compared to plutonic zircon. Identifying smaller episodic magma pulses in a larger magmatic complex places constraints on potential magma fluxes and eruptible volumes. High-flux, large volume, plume-related ocean island magmatic systems may have extensive vertically distributed multi-stage magmatic reservoirs and subduction-related systems transcrustal magma reservoirs. By contrast, Oki-Dōzen was a low-flux system with incremental pluton growth and small- to moderate-scale eruptions.
DISORDERS OF PHOSPHOLIPID METABOLISM IN WOMEN WITH AUTOIMMUNE THYROIDITIS IN THE POSTMENOPAUSEAL PERIOD
Authors: Goncharova Olga 
Published: June 2022

Thyroid hormones are key regulators of metabolic processes. Receptors for triiodothyronine and thyroxine
found not only in the cytoplasm, mitochondria and nucleus, but also on cell membranes,
therefore, these hormones penetrate the target cells fairly quickly and can directly affect the processes that take place
in these organelles.
The Usability of a Smartphone-Based Fall Risk Assessment App for Adult Wheelchair Users: Observational Study
Authors: Frechette Mikaela , Fanning Jason , Hsieh Katherine , Rice Laura , Sosnoff Jacob 
Published: June 2022

Background
Individuals who use wheelchairs and scooters rarely undergo fall risk screening. Mobile health technology is a possible avenue to provide fall risk assessment. The promise of this approach is dependent upon its usability.

Objective
We aimed to determine the usability of a fall risk mobile health app and identify key technology development insights for aging adults who use wheeled devices.

Methods
Two rounds (with 5 participants in each round) of usability testing utilizing an iterative design-evaluation process were performed. Participants completed use of the custom-designed fall risk app, Steady-Wheels. To quantify fall risk, the app led participants through 12 demographic questions and 3 progressively more challenging seated balance tasks. Once completed, participants shared insights on the app’s usability through semistructured interviews and completion of the Systematic Usability Scale. Testing sessions were recorded and transcribed. Codes were identified within the transcriptions to create themes. Average Systematic Usability Scale scores were calculated for each round.

Results
The first round of testing yielded 2 main themes: ease of use and flexibility of design. Systematic Usability Scale scores ranged from 72.5 to 97.5 with a mean score of 84.5 (SD 11.4). After modifications were made, the second round of testing yielded 2 new themes: app layout and clarity of instruction. Systematic Usability Scale scores improved in the second iteration and ranged from 87.5 to 97.5 with a mean score of 91.9 (SD 4.3).

Conclusions
The mobile health app, Steady-Wheels, has excellent usability and the potential to provide adult wheeled device users with an easy-to-use, remote fall risk assessment tool. Characteristics that promoted usability were guided navigation, large text and radio buttons, clear and brief instructions accompanied by representative illustrations, and simple error recovery. Intuitive fall risk reporting was achieved through the presentation of a single number located on a color-coordinated continuum that delineated low, medium, and high risk.
Intervention in the Timeliness of Two Electrocardiography Types for Patients in the Emergency Department With Chest Pain: Randomized Controlled Trial
Authors: Yoo Suyoung , Chang Hansol , kim Taerim , yoon Hee , Hwang Sung Yeon , Shin Tae Gun , Sim Min Seob , Jo Ik joon , Choi Jin-Ho , Cha Won Chul 
Published: June 2022

Background
In the emergency department (ED), the result obtained using the 12-lead electrocardiography (ECG) is the basis for diagnosing and treating patients with chest pain. It was found that performing ECG at the appropriate time could improve treatment outcomes. Hence, a wearable ECG device with a timer can ensure that the findings are continuously recorded.

Objective
We aimed to compare the time accuracy of a single-patch 12-lead ECG (SP-ECG) with that of conventional ECG (C-ECG). We hypothesized that SP-ECG would result in better time accuracy.

Methods
Adult patients who visited the emergency room with chest pain but were not in shock were randomly assigned to one of the following 2 groups: the SP-ECG group or the C-ECG group. The final analysis included 33 (92%) of the 36 patients recruited. The primary outcome was the comparison of the time taken by the 2 groups to record the ECG. The average ages of the participants in the SP-ECG and C-ECG groups were 63.7 (SD 18.4) and 58.1 (SD 12.4) years, respectively.

Results
With a power of 0.95 and effect sizes of 0.05 and 1.36, the minimum number of samples was calculated. The minimum sample size for each SP-ECG and C-ECG group is 15.36 participants, assuming a 20% dropout rate. As a result, 36 patients with chest pain participated, and 33 of them were analyzed. The timeliness of SP-ECG and C-ECG for the first follow-up ECG was 87.5% and 47.0%, respectively (P=.74). It was 75.0% and 35.2% at the second follow-up, respectively (P=.71).

Conclusions
Continuous ECG monitoring with minimal interference from other examinations is feasible and essential in complex ED situations. However, the precision of SP-ECG has not yet been proved. Nevertheless, the application of SP-ECG is expected to improve overcrowding and human resource shortages in EDs, though more research is needed.

Trial Registration
ClinicalTrials.gov NCT04114760; https://clinicaltrials.gov/ct2/show/NCT04114760
The Effectiveness of Web-Based Psychotherapy to Treat and Prevent Burnout: Controlled Trial
Authors: Michelsen Clive , Kjellgren Anette 
Published: June 2022

BackgroundBurnout is a hidden productivity killer in organizations. Finding a solution to efficiently measure and proactively prevent or rehabilitate employees with burnout is a challenge. To meet this unabated demand, companies and caregivers can focus on proactive measures to prevent “Burnout as an Occupational Phenomenon.”ObjectiveWe aimed to address effectiveness, reliability, and validity of the empowerment for participation (EFP) batch of assessments to measure burnout risk in relation to the efficacy of web-based interventions using cognitive behavioral therapy (CBT) and floating to improve mental health and well-being. We introduced three risk assessments: risk for burnout, risk of anxiety, and risk for depression.MethodsWe used an interventional, empirical, and parallel design using raw EFP psychometric data to measure the effectiveness of web-based therapy to reduce the risk of burnout between a control group and web-based therapy group. A total of 50 participants were selected. The rehabilitation and control groups consisted of 25 normally distributed employees each. The rehabilitation group received therapy, whereas the control group had not yet received any form of therapy. IBM SPSS was used to analyze the data collected, and a repeated measures ANOVA, an analysis of covariance, a discriminant analysis, and a construct validity analysis were used to test for reliability and validity. The group was selected from a list of employees within the My-E-Health ecosystem who showed a moderate or high risk for burnout. All assessments and mixed-method CBT were web-based, and floating was conducted at designated locations. The complete EFP assessment was integrated into a digital ecosystem designed for this purpose and therapy, offering a secure and encrypted ecosystem.ResultsThere was a statistically significant difference between pre- and postassessment scores for burnout. The reliability of the burnout measure was good (Cronbach α=.858; mean 1.826, SD 3.008; Cohen d=0.607; P<.001) with a high validity of 0.9420. A paired samples 2-tailed test showed a good t score of 4.292 and P<.001, with a good effect size, Cohen d=0.607. Web-based therapy reduced the risk for burnout in participants compared with the control group. Tests of between-subject effects show F=16.964, a significant difference between the control group and the web-based therapy group: P<.001, with movement between the group variables of 0.261 or 26.1% for the dependent variable.ConclusionsThis study suggests good reliability and validity of using web-based interventional mixed methods CBT to reduce the risk of burnout. The EFP batch of web-based assessments could reliably identify morbidity risk levels and successfully measure clinical interventions and rehabilitation with consistently reliable results to serve as both a diagnostic and therapeutic tool worthy of major research in the future.Trial RegistrationClinicalTrials.gov NCT05343208; https://clinicaltrials.gov/ct2/show/NCT05343208
The City of Ottawa’s Smart Growth Challenge
Authors: Kipper Karyn 
Published: June 2022

As municipalities continue to address urban sprawl and development issues, smart growth principles are being adopted into Official Plans. However, despite their incorporation within municipal and provincial planning documents, implementation gaps remain. This paper explores and seeks to understand this gap using a City of Ottawa case study. Through a content analysis of the preliminary document for the City’s New Official Plan, this paper argues that the City of Ottawa will incorporate smart growth principles into its New Official Plan, but will continue to experience institutional, political, economic and socio-cultural barriers to implementation. It is key that policymakers, city staff, and smart growth advocates identify and address these barriers during the planning process by engaging with federal and provincial governments, as well as community stakeholders. Additional research, such as into the impact of Covid-19 on municipalities, will be essential for policymakers and city staff in addressing these barriers in the future.
A Reconciliatory Pathway for Providing Decent Work for Indigenous Peoples Within the Nonprofit Sector
Authors: Mintram Bill 
Published: June 2022

Nonprofit organizations across Canada are advancing reconciliatory pathways in providing decent work for Indigenous peoples. This article explores the area of decent work, offering an Indigenous and reconciliatory lens to reflect upon organizational systems, structures, and policies. When Indigenous self-determination and ways of knowing, doing, or being are better understood and accommodated, a nonprofit’s ability to recruit, employ, support, and retain Indigenous employees can change dramatically. This challenge requires an ongoing practice of listening, learning, and then acting. This paper explores Indigenous rights and self-determination, equity, cultural safety and humility, the roles of Elders and Knowledge Keepers, representative workforces, and policy considerations. As nonprofit leaders and boards champion changes within an organizational culture that outline reconciliatory pathways, these shifts in ways of doing, knowing, and being can become sustainable and lead to long-term, transformational change.
PENTINGNYA KUALITAS PRIBADI KONSELOR DALAM PELAKSANAAN KONSELING INDIVIDUAL
Authors: Haolah Siti , Atus Atus , Irmayanti Rima 
Published: June 2022

Konselor sebagai sebuah profesi sudah pasti memiliki standar kualitas. Salah satu kualitas konselor adalah kualitas pribadi konselor. Kualitas pribadi konselor khususnya di Indonesia mencakup: (1) beriman dan bertakwa kepada Tuhan yang Maha Esa; (2) menghargai dan menjunjung tinggi nilai-nilai kemanusiaan; (3) menunjukkan integritas dam stabilitas kepribadian yang kuat; dan (4) menampilkan kinerja berkualitas tinggi.Konseling individual merupakan kunci semua kegiatan bimbingan dan konseling. Proses konseling individual merupakan relasi antara konselor dan konseli dengan tujuan agar dapat mencapai tujuan konseli. Tujuan utama dari konseling individual adalah pengentasan masalah konseli, sehingga konselor memiliki tanggung jawab membantu konseli dalam pengentasan masalah tersebut dengan menggunakan keterampilan dan pendekatan dalam konseling melalui tahapan-tahapan proses konseling. Kualitas pribadi konselor dalam proses konseling individual merupakan titik tumpu antara pengetahuan dan keterampilan dari konselor. Dengan kata lain keberhasilan atau keefektifan dalam proses konseling dipengaruhi oleh kualitas pribadi konselor dalam melakukan teknik atau keterampilan dalam setiap tahap peroses konseling. Kata kunci : Kualitas pribadi konselor, konseling individual
MEMBANGUN RASA EMPATI MELALUI TEKNIK SOSIODRAMA PADA SISWA SMP & SMA
Authors: Putra Muhammad Fajar Sidik Jamaludin , Daffa Muhammad , Zakhullu Stefanus Fati 
Published: June 2022

Empati adalah kemampuan untuk membayangkan apa yang mungkin dirasakan atau dipikirkan oleh orang lain dan juga kemampuan untuk merasakan kemampuan orang lain. Tujuan Penelitian ini adalah meningkatkan rasa empati siswa melalui layanan bimbingan dan konseling teknik sosiodrama. Metode penelitiannya dengan menganalisis beberapa jurnal yang sudah ada agar mendapatkan beberapa metode yang bisa dipakai Guru BK ketika mengajar. Hasil penelitian menunjukkan bahwa teknik sosiodrama secara statistik dapat secara efektif membangun rasa empati pada siswa dengan jenjang dunia pendidikan SMP dan SMA berdasarkan dari beberapa penelitian yang di ungkapkan sebelumnya Kata Kunci : Sosiodrama, Empati
GAMBARAN PERENCANAAN KARIER SISWA SMP
Authors: Rosmana Fera Hertiani , Wikanengsih Wikanengsih , Suherman Maya Masyita 
Published: June 2022

Career planning is a process by which individuals can identify and take steps to achieve their career goals. Junior high school students in general have not been able to make good career plans, they do not have much information about careers, be it about secondary school or specialization in education and also work. The purpose of this study is to describe the description of junior high school student career planning. This research uses descriptive qualitative method. The subjects of this study were two students related to career planning at MTs Sirnamikin. The data collection techniques of this research were interviews and direct observation through school observations. The results showed that the potential and abilities of each student were different. Students must learn to consider and find a variety of information about the career they want. And so that all of this can materialize as they expect, therefore a good career planning is needed. Keywords: Career Planning, Middle School Students