bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indole acetic acid/auxin-responsive gene TrIAA27 of white clover improves growth and enhances drought and salt tolerance in Arabidopsis
Authors: Iqbal Muhammad Zafar , Peng Yan 
Published: November 2022

Abstract
In plants, auxin/indole acetic acid proteins (Aux/IAA) are transcriptional regulators that regulate developmental processes and respond to external stimuli, including phytohormones. However, regulatory functions of Aux/IAA family genes have not been reported in white clover. We successfully isolated and cloned Aux/IAA family genes TrIAA27 from white clover cDNA in the current study. Expression analysis showed it was strongly induced in response to drought, salt, and Aluminum stresses in white clover, and its protein was localized in the nucleus. The overexpression of TrIAA27 in transgenic Arabidopsis indicated it improves plant stature, including plant size, leaf area, and biomass and roots growth compared to wild. Furthermore, TrIAA27 improved drought and salt tolerance in transgenic lines by decreasing wilting rate, relative electrical conductivity (REC), and improving relative water contents RWC, chlorophyll contents, and photochemical efficiency compared to wild. These results suggested that overexpression of TrIAA27 enhances plant growth and mitigates the effects of different stresses; therefore, it is a potential candidate to improve biomass, drought, and aluminum tolerance of white clover.
Extractive Summarization of Scientific Paperin Turkish With Deep Learning
Authors: Alagoz Nazan Kemaloglu , Kucuksille Ecir Ugur 
Published: November 2022

Abstract
The widespread use of the internet today, along with the rapidly increas-ing information, has brought along great information pollution. It hasbecome a big problem for internet users to obtain meaningful data fromthis large and noisy data. Text summarization, which is generally usedon texts obtained from digital media, has also been used for summa-rizing scientific articles in different fields. In this study, a scientific textsummary study was carried out to be used on Turkish articles writ-ten in the field of informatics. A large Turkish Informatics Literaturedata set was created with the articles collected from Dergipark. In addi-tion to the text pre-processing studies available in the literature on thisdata set, a new original pre-processing function has been developed bythe scientific article format. While summarizing, Deep Belief Networks(DIA), which has an increasing use in the field of natural language pro-cessing in the literature, has been used. To measure the performanceof the developed system, reference summaries were created with theBERT algorithm, which is a pre-trained natural language processingmodel. After the scientific articles were summarized with BERT andDeep Belief Networks, the abstracts were compared with BERT Scoreand BART Score, a specialized comparison metric of the BERT Model.The results showed that the developed Turkish Informatics LiteratureSummarization Method constitutes a summary of a scientific articlewith 0.78 F-Score and 0.68 BART Score in the BERT Score metric.
Cytotoxicity, immunomodulatory, and anti-inflammatory activity of FMB extract (Fused, Micronized and Bio-activated) and its standardized extract: A comparative evaluation
Authors: Ibrahim Mohammad , Gokarn Vijay , Tamoli Sanjay 
Published: November 2022

Abstract
Curcuma longa (Turmeric) has been utilized for centuries in the Ayurvedic system of medicine for the treatment of various diseases and disorders. In the present study, essential trace elements (ETEs) fused in standardized extract of curcumin by utilizing an advanced technology called FMB [(fusion (F), micronization (M), bio-activation (B)] was investigated for its cytotoxicity, immunomodulatory and anti-inflammatory activities against the conventional standardized extrcat. Results of the elemental analysis showed that FMB technology significantly replenishes Iron and Zinc in the standardized extract. Cytotoxicity results revealed no toxic effect in the tested concentration. In vitro immunomodulatory activity showed that FMB extract of Curcuma longa significantly stimulates the spleen cell proliferation as compared to standardized extract and almost similar results were found in pinocytic activation. In addition, anti-inflammatory results showed that FMB extracts remarkably reverse the level of TNF-α as compared to standardized extract. Summarily, overall results showed FMB extract is more beneficial than standardized extract. Hence, we can conclude that FMB technique can be used as an effective method and approach to enhance the therapeutic efficacy of herbal medicines especially extracts.
A multimodal sensing CMOS imager based on dual-focus imaging
Authors: Dong Hao , Zheng Xubin , Cheng Chen , Qian Libin , Cui Yaoxuan , Wu Weiwei , Liu Qingjun , Chen Xing , Lu Yanli , Yang Qing , Zhang Fenni , Wang Di 
Published: November 2022

Abstract
Advanced machine intelligence is empowered not only by the ever-increasing computational capability for information processing but also by sensors for collecting multimodal information from complex environments. However, simply assembling different sensors can result in bulky systems and complex data processing. Herein, we show that a complementary metal-oxide-semiconductor (CMOS) imager can be transformed into a compact multimodal sensing platform through dual-focus imaging. By combining lens-based and lensless imaging, visual information, chemicals, temperature, and humidity can be detected with the same chip and output as a single image. As a proof of concept, we equipped the sensor on a micro vehicle and demonstrated multimodal environmental sensing and mapping. We also developed a multimodal endoscope and achieved simultaneous imaging and chemical profiling along a porcine digestive tract. The multimodal CMOS imager is compact, versatile, and extensible and can be widely applied in microrobots, in vivo medical apparatuses, and other microdevices.
A Novel Free-Hand Technique of Pedicle Screw Placement in the Lumbar Spine: Accuracy Evaluation and Preliminary Clinical Results
Authors: Jiang Weiqi , Leng Ao , Meng Lingzhi , Long Zuoyao , Long Yu , Wang Qi 
Published: November 2022

Abstract

Objective
To propose a novel free-hand pedicle screw placement technique in the lumbar spine and investigate its accuracy and safety in clinical practice.
Methods
110 patients with herniation of a single lumbar disc were recruited for our study. All patients were consistently treated with posterior discectomy, interbody fusion, and transpedicular internal fixation. For 54 patients in the observation group, the pedicle screws were placed with our technique, which is located at 4 mm below the superior edge of the transverse process in line with the lateral margin of the superior articular process. For 56 patients in the control group, pedicle screws were placed according to the traditional crista lambdoidalis method. Comparisons were made in terms of the operation time, blood loss, time for exposure, the accuracy of placement, and postoperative complications. In addition, we prospectively applied our method to 64 patients with indistinguishable crista lambdoidalis and evaluated the accuracy of screw placement and clinical outcomes.
Results
There was no significant difference in intraoperative bleeding, accuracy of placement, and postoperative complications between our technique and the traditional crista lambdoidalis method (P > 0.05). However, the exposure time before screw placement (12.8 ± 0.3 vs 17.4 ± 0.3, p = 0.001) and the total surgery time (97.2 ± 1.9 vs 102.3 ± 0.9, p = 0.020) were significantly shortened with our method. Additionally, in cases of indistinguishable crista lambdoidalis, our technique showed satisfying accuracy, with 97.6% screws placed in appropriate trajectory on the first attempt and all screws eventually positioned in the safe zone according to the Gertzbein Robbins grading. All patients experienced steady improvement after surgery, as assessed with the visual analog pain scale and the Japanese Orthopaedic Association (JOA) score.
Conclusion
This study highlights a safe and effective technique for pedicle screw placement in the lumbar spine, which is particularly useful in cases of vertebral fracture and severe hyperplasia or degeneration of the facet joint.
Poly(β-amino ester)s-based delivery systems for targeted transdermal vaccination
Authors: Puigmal Núria , Ramos Víctor , Artzi Natalie , Borrós Salvador 
Published: November 2022

Abstract
Nucleic acid vaccines have become a transformative technology to fight emerging infectious diseases. However, pursuing alternative routes of administration such as the transdermal could boost their therapeutic merit given the complex immune cell reservoir present in the skin capable of engendering robust immune responses. We have generated a novel library of vectors derived from poly(β-amino ester)s (PBAEs) that include oligopeptide-termini and a natural ligand, mannose, for targeted transfection of antigen presenting cells (APCs) in the epidermal milieu. Our results reaffirmed terminal decoration of PBAEs with oligopeptide chains as a powerful tool to induce cell-specific transfection, identifying an outstanding candidate with a ten-fold increased transfection efficiency over commercial controls in vitro. The inclusion of mannose in the PBAE backbone rendered an additive effect and increased transfection levels, achieving superior gene expression in human monocyte-derived dendritic cells such as Langerhans cells and other accessory antigen presenting cells. Moreover, top performing candidates were capable of mediating surface gene transfer when deposited as polyelectrolyte films onto transdermal devices such as microneedles, offering alternatives to conventional hypodermic administration. We predict that the use of highly efficient delivery vectors derived from PBAEs could advance clinical translation of nucleic acid vaccination over protein- and peptide-based strategies.
Zwitterionic Bergman-Triggered Cascade Polymerization: A Plateau Reaction Leading to Metal-Graphene Nanoribbon Semiconductors Using Boron-Metal Couple
Authors: Vidhani Dinesh , Ubeda Rosemary , Sautie Thalia , Vidhani Diana , Mariappan Manoharan 
Published: November 2022

Abstract
With a rapid growth in artificial intelligence, designing high-speed and low power semiconducting material is of utmost importance. This investigation provides a theoretical basis to access covalently-bonded transition metal-graphene nanoribbon (TM-GNR) hybrid semiconductors whose DFT-computed bandgaps were much narrower than the commonly used pentacene. A systematic optimization of substrates containing remotely-placed boronyl groups and the transition metals produced the zwitterions via ionic Bergman cyclization (i-BC) and unlocked the polymerization of metal-substituted polyenynes. Aside from i-BC, the subsequent steps showed plateau-TS involving structureless transition regions. A multivariate analysis revealed a strong dependence of activation energy and the cyclization mode on the electronic nature of boron and Au(I). Consequently, three regions corresponding to radical Bergman (r-BC), ionic Bergman (i-BC), and ionic Schreiner-Pascal (i-SP) cyclizations were identified. The boundaries between these regions corresponded to the mechanistic shift induced by three-center-three-electron (3c-3e) hydrogen bond, three-center-four-electron (3c-4e) hydrogen bond, and vacant p-orbital on boron. The ideal combination for cascade polymerization was observed near the boundary between i-BC and i-SP.
Accelerating Digital Transformation during the COVID-19 Pandemic: A Model Design for Indonesian MSMEs
Authors: Broto Legowo Mercurius , Sorongan Fangky Antoneus 
Published: November 2022

The acceleration of digital transformation and business model innovations fundamentally improves business growth and performance. However, the occurrence of the COVID-19 pandemic has a significant influence on the insecurity of many business actors, especially Micro Small Medium Enterprises (MSMEs). There are many efforts to recover the national economy by accelerating digital transformation for MSMEs programs by the government of the Republic of Indonesia. However, the problem arises when the process of accelerating digital transformation in Indonesian MSMEs is considered slow to encourage Indonesia’s National Economic Recovery (PEN as shortened in Indonesian) during the COVID-19 pandemic. The research aimed to present a design model for accelerating digital transformation during the COVID-19 pandemic for Indonesian MSMEs. The research applied a descriptive-analytic approach with a qualitative method. Then, the analysis reviewed the content analysis of previous research. The two research models were analyzed. One was from Indonesia, while another one was from outside Indonesia. The results of the model design reveal that the acceleration of digital transformation is influenced by business driving factors and impacts the gaining value from business model innovations. The model of accelerating digital transformation for MSMEs is expected to contribute significantly to supporting government programs and strengthening National Economic Recovery policies during the COVID-19 pandemic.
The effectiveness of using a homeopathic preparation containing calendula, witch hazel, aesculus, menthol and zinc oxide in patients with nasal obstruction in vasomotor and chronic subatrophic rhinitis
Authors: Zakharova G. P. , Ivanov N. I. 
Published: November 2022

Introduction. In recent years, the world has seen an increase in the number of patients with difficulty in nasal breathing due to nasal obstruction, one of the causes of which are functional disorders of the nasal mucosa in various forms of rhinitis. Frequent use of intranasal decongestants among the population further contributes to the lack of effectiveness of conservative treatment and the need for surgical correction to restore free nasal breathing. This article discusses the possibility of using a homeopathic preparation containing calendula, witch hazel, aesculus, menthol and zinc oxide in patients with nasal obstruction in vasomotor and chronic subatrophic rhinitis to stop the clinical manifestations of the disease and improve the quality of life of patients. Аim. Тo evaluate the effectiveness of a drug containing calendula, witch hazel, aesculus, menthol and zinc oxide in patients with vasomotor and chronic subatrophic rhinitis in the complex treatment of nasal obstruction. Мaterials and methods. The study involved 48 adult patients of both sexes, aged 20 to 50 years, diagnosed with vasomotor (idiopathic) rhinitis in 24 and chronic subatrophic rhinitis in 24 patients. The studied preparation containing calendula, witch hazel, esculus, menthol and zinc oxide was smeared on the mucous membrane of the nasal cavity by laying gauze turundas for 5 minutes, 3 times a day, while the course of treatment was 10 days. The efficacy and safety of the drug was assessed by the dynamics of the severity of subjective symptoms, objective clinical data during control examinations by an otorhinolaryngologist in points, as well as by the presence of side effects in the treatment of the disease. Results. Results of the study showed a pronounced positive trend in the form of relief of subjective complaints and the main clinical manifestations of the disease, accompanied by an improvement in the quality of life in patients in both groups examined during treatment. Side effects were not observed in patients in both study groups. Conclusions. Based on the results of the study, conclusions were drawn about the efficacy and safety of using a complex homeopathic preparation containing calendula, witch hazel, esculus, menthol and zinc oxide in an adult group of patients with nasal obstruction, which makes it possible to recommend it for widespread use for the complex treatment of nasal syndrome. obstruction in vasomotor and chronic subatrophic rhinitis, as well as other forms of rhinitis accompanied by nasal obstruction syndrome.
Results of unloading therapy of acute infectious rhinitis with 0.1% xylometazoline
Authors: Kiselev A. B. , Abdulkerimov K. T. , Chaukina V. A. , Abdulkerimov Z. Kh. , Andamova O. V. , Avtushko A. S. 
Published: November 2022

Introduction. Acute infectious rhinitis refers to the frequent causes of discharge therapy with nasal decongestants. The aim to analyze the clinical features of unloading therapy of acute infectious rhinitis with 0.1 % xylometazoline according to the materials of the research centers of Novosibirsk and Yekaterinburg. Materials and methods. In the research centers of Novosibirsk and Yekaterinburg, patients with acute infectious rhinitis were observed. Intranasal therapy in the study groups (group 1) and in the comparison groups (group 2) was carried out with 0.1 % xylometazoline spray for 7 days. Group 2 additionally received silver preparation intranasally. The need for decongestant and the state of mucociliary transport (MCT) were evaluated. Results and discussion. Initially, patients with normal MCT rate at 1 visit in Novosibirsk accounted for 20.8 % in group 1 and 34.78 % in group 2; in Yekaterinburg – 29.17 % of patients in group 1 and 25% of patients in group 2. In the study groups, 54.2 % of patients in Novosibirsk and 100 % in Yekaterinburg used decongestant on day 5; in the comparison groups – 41.7% in Novosibirsk; 83.3% of patients in Yekaterinburg. On day 5, the volumetric air flow velocity was determined to be more than 900 cm3/s in all patients. Decongestant was used for more than 7 days by 40.35 % of patients in the first groups and 12.45 % of patients in the second groups. Inhibition of MCT on the 14 th day of follow-up, detected in two research centers, amounted to 5.26 % of patients. Conclusions. On the 5th day of unloading therapy, nasal breathing is objectively free. Intranasal antiseptic therapy reduces the probability of using decongestant for more than 7 days by 27.9 %. Inhibition of MCT when using 0.1 % xylometazoline should be attributed to frequent reactions.
THE CULTURAL ADAPTATION, RELIABILITY AND VALIDITY OF THE TURKISH VERSION OF THE SIMPLE PHYSICAL ACTIVITY QUESTIONNAIRE IN COMMON MENTAL DISORDERS
Authors: ŞENEL Aybike , BİRİNCİ Tansu , İPEKÇİOĞLU Derya , YEŞİLKAYA Haluk , KAYA MUTLU Ebru 
Published: November 2022

Purpose: This study aims to evaluate the validity and reliability of the Turkish version of the Simple Physical Activity Questionnaire (SIMPAQ-T) in patients with common mental disorders.
Methods: A total of eighty-one patients (mean age: 40.14±13.05 years) were included in this study. The SIMPAQ-T was used to evaluate the participants' physical activity levels and sedentary behaviors. To be used as descriptive data, DSM-5 Level 1 Cross-Cutting Symptom Measure-Adult was used to evaluate mental health symptomatology. International Physical Activity QuestionnaireShort Form (IPAQ-SF) and Brief Psychiatric Rating Scale (BPRS) were used to test the validity of the questionnaire.
Results: The items of the SIMPAQ-T exhibited excellent intercorrelation coefficient (ICC) values (time spent in bed (0.93 (95% CI: 0.90-0.96)), sedentary time 0.87 (95% CI: 0.80-0.92), walking time 0.98 (95% CI: 0.98-0.99), exercise time 0.99 (95% CI: 0.99-0.99), and incidental activity time 0.95 (95% CI: 0.92-0.97)). The SIMPAQ-T was moderately correlated with IPAQ-SF in terms of sedentary (rho=0.641, p=0.001) and walking time (rho=0.564, p=0.001), indicating good construct validity. However, the BPRS had a significant correlation with only the sedentary time of the SIMPAQ (rho=0.246, p=0.022), indicating convergent validity was poor.
Conclusion: The SIMPAQ-T is semantically and linguistically adequate to quickly assess physical activity level and sedentary behavior in patients with common mental disorders.
Bioactives from Marine Organisms and their Potential Role as Matrix Metalloproteinase Inhibitors
Authors: Qian Zhong Ji , Thomas Noel Vinay , Monica Diyya Apoorva Salomy , Kim Se-Kwon , Faraj Kaeuis Aziz , Ghafoor Dlzar Dlshad , Tigabu Bereket Molla 
Published: November 2022

Abstract:
Recent research has revealed the role of metalloproteinases in a number of severe pathological illnesses, including cardiac, cartilage, neurological, and cancer-related diseases that are fatal to humans. Metalloproteinases are a subclass of endopeptidases that comprise structurally identical enzymes known as Matrix Metalloproteinases [MMPs] that are solely involved in extracellular matrix degradation and play a significant regulatory function in tissue remodeling.
Improper regulation and expression of MMPs have been linked to several life-threatening pathological conditions in humans. Hence there is an ever-growing interest in various research communities to identify and report the Matrix Metalloproteinase Inhibitors [MMPIs]. In spite of several chemically synthesized MMPIs being available currently, several unpleasant side effects, un-successful clinical trials have made use of synthetic MMPIs as a risky strategy. Several natural product researchers have strongly recommended and reported many natural resources like plants, microorganisms, and animals as greater resources to screen for bioactives that can function as potential natural MMPIs. Marine environment is one of the vast and promising resources that harbor diverse forms of life known to synthesize biologically active compounds. These bioactive compounds from marine organisms have been reported for their unparalleled biological effects and have profound applications in cosmeceutical, nutraceutical, and pharmaceutical research. Several research groups have reported an umpteen number of medicinally unmatched compounds from marine flora and fauna, thus driving researchers to screen marine organisms for natural MMPIs. In this review, our group has reported the potential MMPIs from marine organisms.
Computational Investigation of Ligand Binding of Flavonoids in Cytochrome
P450 Receptors
Authors: Wilson Philippe B. , Odoemelam Chiemela S. , Hunter Elena , Ahmad Zeeshan , Kamerlin Caroline Lynn , White Samuel 
Published: November 2022

Aim:
The cytochrome P450 enzymes play a significant role in regulating cellular and physiological processes by activating endogenous compounds. They also play an essential role in the detoxification process of xenobiotics. Flavonoids belong to a class of polyphenols found in food, such as vegetables, red wine, beer, and fruits, which modulate biological functions in the body.

Method:
The inhibition of CYP1A1 and CYP1B1 using nutritional sources has been reported as a strategy for cancer prevention. This study investigated the interactions of selected flavonoids binding to the cytochrome P450 enzymes (CYP1A1 and CYP1B1) and their ADMET properties in silico. From docking studies, our findings showed flavonoids, isorhamnetin and pedalitin, to have the strongest binding energies in the crystal structures 6DWM and 6IQ5.

Results/Discussion:
The amino acid residues Asp 313 and Phe 224 in 6DWM interacted with all the ligands investigated, and Ala 330 in 6IQ5 interacted with all the ligands examined. The ligands did not violate any drug-likeness parameters.

Conclusion:
These data suggest roles for isorhamnetin and pedalitin as potential precursors for natural product-derived therapies.