bluuebunny/crossref_metadata_2025_split huggingface dataset:
A national stratification of the global macroeconomic burden of central nervous system cancer
Authors: Gerstl Jakob V. E. , Yearley Alexander G. , Kilgallon John L. , Lassarén Philipp , Robertson Faith C. , Herdell Vendela , Wang Andy Y. , Segar David J. , Bernstock Joshua D. , Laws Edward R. , Ranganathan Kavitha , Smith Timothy R. 
Published: October 2022

OBJECTIVE
Country-by-country estimates of the macroeconomic disease burden of central nervous system (CNS) cancers are important when determining the allocation of resources related to neuro-oncology. Accordingly, in this study the authors investigated macroeconomic losses related to CNS cancer in 173 countries and identified pertinent epidemiological trends.

METHODS
Data for CNS cancer incidence, mortality, and disability-adjusted life years (DALYs) were collected from the Global Burden of Disease 2019 database. Gross domestic product data were combined with DALY data to estimate economic losses using a value of lost welfare approach.

RESULTS
The mortality-to-incidence ratio of CNS cancer in 2019 was 0.60 in high-income regions compared to 0.82 in Sub-Saharan Africa and 0.87 in Central Europe, Eastern Europe, and Central Asia. Welfare losses varied across both high- and low-income countries. Welfare losses attributable to CNS cancer in Japan represented 0.07% of the gross domestic product compared to 0.23% in Germany. In low- and middle-income countries, Iraq reported welfare losses of 0.20% compared to 0.04% in Angola. Globally, the DALY rate in 2019 was the same for CNS cancer as for prostate cancer at 112 per 100,000 person-years, despite a 75% lower incidence rate, equating to CNS cancer welfare losses of 182 billion US dollars.

CONCLUSIONS
Macroeconomic losses vary across high- and low-income settings and appear to be region specific. These differences may be explained by differences in regional access to screening and diagnosis, population-level genetic predispositions, and environmental risk factors. Mortality-to-incidence ratios are higher in low- and middle-income countries than in high-income countries, highlighting possible gaps in treatment access. Quantification of macroeconomic losses related to CNS cancer can help to justify the spending of finite resources to improve outcomes for neuro-oncological patients globally.
Phase II trial of icotinib in adult patients with neurofibromatosis type 2 and progressive vestibular schwannoma
Authors: Zhao Fu , Li Shi-wei , Zhang Shun , Li Peng , Zhao Chi , Zhao Xiao-bin , Wang Chun-Hong , Zhang Jing , Wang Bo , Liu Pi-nan 
Published: October 2022

OBJECTIVE
Neurofibromatosis type 2 (NF2) is a rare autosomal dominant syndrome associated primarily with bilateral vestibular schwannomas (VSs). Conventional surgical or radiosurgical treatments for VS in NF2 usually result in high risks of hearing loss and facial nerve impairment, while there is no validated medical option to date. This single-institution phase II study evaluated the efficacy and safety of icotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with NF2 and progressive VS.

METHODS
Icotinib was administered daily at 375 mg orally in a continuous 28-day course for up to 12 courses. The primary endpoint of the study was radiographic response assessed by brain MRI using 3D volumetric tumor analysis and defined as a ≥ 20% decrease in VS volume. Hearing function was evaluated as a secondary endpoint, with response defined as a statistically significant increase in word recognition scores.

RESULTS
Ten eligible patients with a mean age of 23.8 years were enrolled. One patient (10%) with bilateral tumors experienced an objective radiographic response (−23.58% and −22.01%). Three (43%) of 7 patients met the hearing response criteria. At 12 months, the estimated progression-free survival was 82.0% (95% CI 42.3%–95.5%) for volumetric progression and 69.2% (95% CI 37.3%−87.2%) for hearing progression. Common mild to moderate adverse events included rash (90%), diarrhea (50%), myalgia (20%), and nausea/gastrointestinal pain (20%).

CONCLUSIONS
Icotinib carries minor toxicity and is associated with radiographic and hearing responses in patients with NF2 and progressive VS.
Neurodevelopment in unilateral coronal craniosynostosis: a systematic review and meta-analysis
Authors: Fotouhi Annahita R. , Chiang Sarah N. , Peterson Andrew M. , Doering Michelle M. , Skolnick Gary B. , Naidoo Sybill D. , Strahle Jennifer M. , McEvoy Sean D. , Patel Kamlesh B. 
Published: October 2022

OBJECTIVE
The current literature on unilateral coronal craniosynostosis is replete with repair techniques and surgical outcomes; however, information regarding neurodevelopment remains unclear. Therefore, the aim of this systematic review and meta-analysis was to comprehensively assess the neurodevelopmental outcomes of patients with unicoronal craniosynostosis compared with their healthy peers or normative data.

METHODS
A systematic review of the Ovid MEDLINE, Embase, Web of Science, Scopus, Cochrane Library, and ClinicalTrials.gov databases from database inception to January 19, 2022, was performed. Included studies assessed neurodevelopment of patients with unicoronal craniosynostosis. Two independent reviewers selected studies and extracted data based on a priori inclusion and exclusion criteria. Results of developmental tests were compared with normative data or controls to generate Hedges’ g statistics for meta-analysis. The quality of included studies was evaluated using the National Institutes of Health Assessment Tool.

RESULTS
A total of 19 studies were included and analyzed, with an overall fair reporting quality. A meta-analysis of 325 postoperative patients demonstrated that scores of general neurodevelopment were below average but within one standard deviation of the norm (Hedges’ g = −0.68 [95% CI −0.90 to −0.45], p < 0.001). Similarly, postoperative patients exhibited lower scores in verbal, psychomotor, and mathematic outcome assessments.

CONCLUSIONS
This systematic review and meta-analysis found that patients with unicoronal craniosynostosis had poorer neurodevelopment, although scores generally remained within the normal range. These data may guide implementation of regular neurocognitive assessments and early learning support of patients with unicoronal craniosynostosis.
Perfectly antimagic total graphs
Authors: Swathi P. , Kumar G. , Jeyabalan R. , Nishanthini R. 
Published: October 2022

An one-one correspondence function λ from V(G) ∪ E(G) to the set {1, 2, …, |V(G) | + |E(G) |} is a total labeling of a finite undirected graph G without loops and multiple edges, where |V(G) |and |E(G) | are the cardinality of vertex and edge set of G respectively. A perfectly antimagic total labeling is a totally antimagic total labeling whose vertex and edge-weights that are also pairwise distint. Perfectly antimagic total (PAT) graph is a graph having such labeling. The topic of discovering perfectly antimagic total labeling of some families of graphs is discussed in this paper. We also came up with certain conclusions about dual of a perfectly antimagic total graphs. Finally, we provided that the necessary and sufficient condition for a dual of a regular and irregular PAT graph to be a PAT graph.
Microbiological analysis of commonly consumed vegetables: A review on the ongoing studies
Authors: Ava Afia Ibnat , Noor Rashed 
Published: October 2022

Vegetables are frequently consumed by people all over the world and hence, the microbiological quality of vegetable especially fresh produces are of significance for the sake of public health sustainability. Vegetables are spoiled by a range of microorganisms including bacteria and fungi. Among the bacterial species, _Corynebacterium_, _Pseudomonas_ spp., _Listeria monocytogenes_, _Clostridium botulinum_, _Erwinia carotovora_, and _Xanthomonas campestris_ are the common vegetable spoilage microorganisms while the fungal genera _Botrytis cinerea_, _Colletotrichum_, _Aspergillus_, _Alternaria_, _Cladosporium_, _Fusarium_, _Penicillium_, and _Rhizopus_ spp. are the prominent spoiling candidates. Understanding vegetable spoilage mechanism/ microbial pathogenesis is important. The harvesting and handling procedures, storage conditions of vegetables, processing, injury of the vegetable plant tissues, and plant resistance against the pathogens are also of significance in order to analyze the toxic metabolites in the affected sites within the vegetables as well as for the prediction of the foodborne illness outbreaks. Implementation of good agricultural practices (GAPs) and good manufacturing practices (GMPs) during vegetable cultivation, harvesting, sorting, storage, transportation, and distribution is important. Moreover, processing of vegetables prior to consumption; i.e., controlling contamination of microbes, a thorough wash with vinegar water, salt water, and other washing means are important preventive measures to ensure the prevention of microbial contamination. Furthermore, up-to-date knowledge on the vegetable spoiling microorganisms, the epidemiology of such microbial contamination, and possible sources and route of the contamination may attribute to the possible future perspective on food safety.
Irrealistic traditions in Russian prose of the first third of the 20th century
Authors:   Moscow State University of Food Production, Astashchenko Elena Vasilievna 
Published: October 2022

The monograph examines the irrealistic traditions in Russian prose of the first third of the XX century. Irrealism as a semantic and style-­forming principle of artistic “belles-­lettres” (as opposed to documentary, artless) at the beginning of the XX century was mentioned in criticism, including by A. A. Blok, N. N. Rusov, N. F. Berner, and it was first designated as a term and justified theoretically in philosophical and philological studies by A. M. Evlakhov. The extreme individualization of a purely artistic, rather than a creative process as a whole, suggests the search for irrealistic features of unpopular works (drafts, manuscripts, unfinished, unpublished, misunderstood texts) or second-rate writers (A. N. Bezhetsky (Maslov), S. P. Bobrov, K. Bolshakov, A. S. Voznesensky (Brodsky), A. A. Galunov, V. V. Hoffman, M. L. Hoffman, S. I. Gusev-­Orenburgsky, A. F. Damanskaya, A. M. Evlakhov, V. Evtihiev, V. A. Zhukovskaya, A. K. Zakrzhevsky, V. A. Carrick, B. A. Koiransky, E. Kurlov, V. Lensky and N. Muravyov (Adbamovich brothers), N. I. Manaseina, O. Norwegian (Kartozhinsky), M. I. Pantyukhov, N. I. Petrovskaya, M. L. Premirov, M. A. Pozharova, A. D. Radlova, N. N. Rusov, B. A. Sadovsky, V. V. Sipovsky, Y. L. Slezkin, A. M. Fedorov, M. Khodyreva, AnChebotarevskaya, F. I. Chernova, G. I. Chulkova), because the flip side of non-demand, external distancing from public life was freedom. Despite the motley picture of the literary process of the Silver Age, this monograph attempts to systematize it (according to the criterion fashionable at that time, which deserved the attention of P. N. Sakulin, A. P. Skaftymov, etc., — irrealism), as well as, according to the Doctor of Philology, academician of the Independent Academy of Aesthetics and Free Arts B. F. Egorov, there is a “solid theoretical foundation and fresh, new material”.
Integration of geophysical information with geological cartography for mineral resources research and other applications in Colombia: examples from the Serranía de San Lucas, Antioquia Batholith and eastern Amazonia
Authors: Lara Norma Marcela , Arias Hernán Darío , Moyano Ismael Enrique , Robayo Adriana , Gómez Ernesto , Ospina Diana , Puentes Manuel , Torrado Sergio , Rojas Óscar , Prieto Gloria 
Published: October 2022

La información geofísica aerotransportada es una herramienta para la interpretación de características geológicas. Las variaciones que se observan en los datos magnéticos y gamma espectrométricos aerotransportados son utilizados, principalmente, como apoyo para diferenciar unidades geológicas, delimitar estructuras y limitar cambios composicionales. En este contexto, el objetivo de este estudio es dar soporte al mapeo geológico a partir de los datos de geofísica aerotransportada de magnetometría y gamma espectrometría en dos regiones del territorio colombiano: a) serranía de San Lucas-Batolito Antioqueño, y b) oriente colombiano. El procesamiento de los datos gamma espectrométricos consiste en generar imágenes de los canales de K, U y Th, además de una composición ternaria en falso color RGB de estos tres canales, con la finalidad de delimitar dominios geológicos-geofísicos. De otro lado, la información de magnetometría se procesa para resaltar características magnéticas anómalas y proveer información acerca del marco estructural de cada una de las áreas de interés.
En la zona comprendida en la serranía de San Lucas-Batolito Antioqueño se delimitaron 27 dominios gamma espectrométricos, interpretados especialmente a partir de las imágenes de composición ternaria; en ellos se observa una buena correlación con la composición de cada una de las unidades litoestratigráficas, lo que permite identificar y delimitar zonas con altas o bajas concentraciones de radioelementos. Además, la correlación de dominios magnéticos con altas y bajas intensidades y texturas magnéticas muestra contrastes entre rocas ígneas, rocas metamórficas y rocas sedimentarias. Por su parte, en la zona oriental, por tener una geología bastante generalizada, la información geofísica, tanto de gamma espectrometría como de magnetometría, sirve de apoyo para depurar y delimitar con mayor exactitud temática las unidades geológicas presentes, así como su marco estructural.
Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods
Authors: Wang Yanjie , Strohm Eric M. , Sun Yang , Wang Zhaoxia , Zheng Yuanyi , Wang Zhigang , Kolios Michael 
Published: October 2022

<p>In this study, optical-triggered multifunctional theranostic agents for photoacoustic/fluorescent imaging and cancer therapy have been developed. This system consists of a perfluorohexane liquid and gold nanoparticles (GNPs) in the core, stabilized by a Poly (lactide-co-glycolic acid) (PLGA) polymer shell. When cancer cells containing PLGAGNPs were exposed to laser pulses, cell viability decreased due to the vaporization of the particles in and around the cells. The particle chemo drug loading and delivery capacity was also investigated in vitro experiments. These particles show potential as photoacoustic imaging and therapy agents for future clinical translation in cancer therapy. </p>
Quantification of Ultrasonic Scattering Properties of In Vivo Tumor Cell Death in Mouse Models of Breast Cancer
Authors: Tadayyon Hadi , Sannachi Lakshmanan , Sadeghi-Naini Ali , Al-Mahrouki Azza , Tran William T. , Kolios Michael , Czarnota Gregory J 
Published: October 2022

<p><em>INTRODUCTION</em>: Quantitative ultrasound parameters based on form factor models were investigated as potential biomarkers of <a href="https://www-sciencedirect-com.ezproxy.lib.ryerson.ca/topics/medicine-and-dentistry/programmed-cell-death" target="_blank">cell death</a> in breast tumor (MDA-231) <a href="https://www-sciencedirect-com.ezproxy.lib.ryerson.ca/topics/medicine-and-dentistry/xenograft" target="_blank">xenografts</a> treated with chemotherapy. <em>METHODS</em>: Ultrasound backscatter <a href="https://www-sciencedirect-com.ezproxy.lib.ryerson.ca/topics/biochemistry-genetics-and-molecular-biology/radiofrequency" target="_blank">radiofrequency</a> data were acquired from MDA-231 breast cancer tumor–bearing mice (<em>n</em> = 20) before and after the administration of chemotherapy drugs at two ultrasound frequencies: 7 MHz and 20 MHz. Radiofrequency <a href="https://www-sciencedirect-com.ezproxy.lib.ryerson.ca/topics/medicine-and-dentistry/spectroscopy" target="_blank">spectral analysis</a> involved estimating the backscatter coefficient from regions of interest in the center of the tumor, to which form factor models were fitted, resulting in estimates of average scatterer diameter and average acoustic concentration (AAC). <em>RESULTS</em>: The ∆AAC parameter extracted from the spherical Gaussian model was found to be the most effective cell death biomarker (at the lower frequency range, <em>r</em>2 = 0.40). At both frequencies, AAC in the treated tumors increased significantly (<em>P</em> = .026 and .035 at low and high frequencies, respectively) 24 hours after treatment compared with control tumors. Furthermore, stepwise <a href="https://www-sciencedirect-com.ezproxy.lib.ryerson.ca/topics/medicine-and-dentistry/multiple-linear-regression-analysis" target="_blank">multiple linear regression analysis</a> of the low-frequency data revealed that a multiparameter quantitative ultrasound model was strongly correlated to cell death determined histologically posttreatment (<em>r</em>2 = 0.74). <em>CONCLUSION</em>: The Gaussian form factor model–based scattering parameters can potentially be used to track the extent of cell death at clinically relevant frequencies (7 MHz). The 20-MHz results agreed with previous findings in which parameters related to the backscatter intensity (i.e., AAC) increased with cell death. The findings suggested that, in addition to the backscatter coefficient parameter ∆AAC, biological features including <a href="https://www-sciencedirect-com.ezproxy.lib.ryerson.ca/topics/medicine-and-dentistry/tumour-heterogeneity" target="_blank">tumor heterogeneity</a> and initial tumor volume were important factors in the prediction of cell death response. </p>
Nonlinear power loss in the oscillations of coated and uncoated bubbles: Role of thermal, radiation and encapsulating shell damping at various excitation pressures
Authors: Sojahrood Amin , Haghi Hossein , Li Q. , Porter T.M. , Karshafian Raffi , Kolios Michael 
Published: October 2022

<p>This study presents the fundamental equations governing the pressure dependent disipation mechanisms in the oscillations of coated bubbles. A simple generalized model (GM) for coated bubbles accounting for the effect of compressibility of the liquid is presented. The GM was then coupled with nonlinear ODEs that account for the thermal effects. Starting with mass and momentum conservation equations for a bubbly liquid and using the GM, nonlinear pressure dependent terms were derived for power dissipation due to thermal damping (Td), radiation damping (Rd) and dissipation due to the viscosity of liquid (Ld) and coating (Cd). The pressure dependence of the dissipation mechanisms of the coated bubble have been analyzed. The dissipated energies were solved for uncoated and coated 2–20 μm in bubbles over a frequency range of 0.25fr-2.5fr (fr is the bubble resonance) and for various acoustic pressures (1 kPa-300 kPa). Thermal effects were examined for air and C3F8 gas cores. In the case of air bubbles, as pressure increases, the linear thermal model looses accuracy and accurate modeling requires inclusion of the full thermal model. However, for coated C3F8 bubbles of diameter 1–8 μm, which are typically used in medical ultrasound, thermal effects maybe neglected even at higher pressures. For uncoated bubbles, when pressure increases, the contributions of Rd grow faster and become the dominant damping mechanism for pressure dependent resonance frequencies (e.g. fundamental and super harmonic resonances). For coated bubbles, Cd is the strongest damping mechanism. As pressure increases, Rd contributes more to damping compared to Ld and Td. For coated bubbles, the often neglected compressibility of the liquid has a strong effect on the oscillations and should be incorporated in models. We show that the scattering to damping ratio (STDR), a measure of the effectiveness of the bubble as contrast agent, is pressure dependent and can be maximized for specific frequency ranges and pressures. </p>
A Holographic Future: Exploring the Capabilities of the Looking Glass Holographic Display
Authors: Carter-Arlt Michael 
Published: October 2022

<p><em>"</em><em>ME: “Hey SIRI. What do you look like?”</em></p>
<p>When I was completing my master’s degree, I pondered this question a lot. If SIRI or any AI had a face, what would it look like? </p>
<p><em>SIRI: “I imagine I probably look like colourful sound waves.”</em></p>
<p>I believe that the future of artificial intelligence (AI) will have a face—or, more accurately, many faces. But, rather than a device or the company that makes it determining what an AI looks like (inevitably giving us 3D variations on an old Winamp visualizer), appearances will be determined and customized by individual users—and will be every bit as varied as the live human beings interacting with them. </p>
<p>In 2018, I demonstrated this idea in front of a class by creating the illusion of myself as an AI hologram. The set-up was simple—just a hacked CD jewel case and a cellphone video of my face, shot in a dark room with blue light—but the effect was convincing enough to capture the attention of my entire class, almost as if nothing else mattered but me and what I was presenting—as though I were the Wizard of Oz. </p>
<p>This experience made me realize just how useful holograms (or the illusion of them) could be in helping increase engagement and combat distractions in a classroom. </p>
<p>As is often the case, my curiosity eventually led me through the Looking Glass." --from the introduction</p>
Lived experiences of stroke survivors in India: A phenomenological study
Authors: Bhagavathy Manjula G , Anniyappa Saravana , Thankappan Radhakrishnan , Bharathi Bindhu 
Published: October 2022

Background: Stroke is a major cause of long-term disability and has a potentially enormous emotional and socio-economic impact on patients, their families, and health services. Perceptions of patients with stroke have already been studied worldwide, which are unique in terms of their cultural background. However, in India, there is a lack of studies about the experience of the disease by stroke survivors and their perspectives of understanding the situation.
Objective: This study aimed to explore lived experience of stroke survivors in India.
Methods: A phenomenological study design was used. In-depth interviews were conducted with a purposive sample of ten stroke survivors who had experienced post-stroke deficits three months to one year after stroke. Data were analyzed using Diekelmann’s hermeneutical approach to identify underlying themes.
Results: Two main themes emerged: (1) emergence of stroke (actual occurrence, mental perception, and recognition of illness) and (2) therapeutic concerns (enhanced and weakened recovery).
Conclusion: Recognizing how patients experience the illness is crucial in planning care for stroke survivors. Strengthening factors enhancing recovery and limiting the hindering factors through effective therapeutic management is a necessity. The findings might also contribute to refining existing interventions and designing holistic multi-component rehabilitation programs that facilitate easy recovery. The study also highlights the need for providing information to general public on recognizing warning signs of stroke.
Digital competence: What makes nurses a ‘big gun’ in the future health industry
Authors: Prasetyo Yunus Adhy 
Published: October 2022

This letter aims to respond to the editorial’s viewpoint by Aungsuroch, Y. and Gunawan, J. related to nurses’ preparation in the industrial revolution 4.0. Without a doubt, the era of disruption creates massive changes in many sectors, including in the health industry, and nurses are demanded to adopt and adapt to the rapid development of information technology. Therefore, digital competence is highly emphasized as an essential skill for today’s nurse generation in order to be the “big gun” of tomorrow.