bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review of antimicrobial activities of medicinal plants against bacterial and fungal microbes: A research trend in Africa from 1980 to 2019
Authors: Achilonu Conrad Chibunna , Udensi Ogbuagu Ugorji 
Published: April 2022

Abstract
Antimicrobial resistance to typical antibiotics is a significant threat to human health worldwide, and its rapid progression have raised serious concern in the treatment of infectious diseases. The cost of commercialising a new antibiotic is high relative to a low return on investment. Medicinal plants are used for the treatment of infections in many countries and are customarily recognised in Africa. Many studies have shown that phytochemicals produced by plants have exerted potential antimicrobial activities against pathogens through various action mechanisms. However, crude extracts from medicinal plants may be an alternative source of antimicrobial resistance modifying agents because of the large range of bioactive compounds. This systematic review aims to assess published articles in Africa on medicinal plants with potential antimicrobial resistant effectives, focusing on bacterial and fungal microbes. To assess this studies, bibliometric model on Scopus and Web of Science databases were used to systematically search for “Antimicrobial Activity’ or “Medicinal Plants” as titles for studies published from 1980 to 2019 in Africa. We identified a total of 2,174 published documents retrieved from 710 sources between 1980 to 2019, and there was an increasing trend of publications over the years. A stringent selection process was established based on clear inclusion and exclusion criteria, yielding 138 data of the most represented medicinal plants, grouped by family and species names. A total of 52 bacterial and 27 fungi were generated in these studies. Egypt, Nigeria, and South Africa were the most represented single and multiple countries with publication, and highest citation counts. In terms of country, Egypt and South Africa had the highest collaborative strength. Most relevant research of 43 articles were published in the Journal of Heterocyclic Chemistry, with Victor Kuete as the 20th most productive author. Natural Product Research was least Journal with 17 published articles. This systematic review study depicts the progression of antimicrobial resistant studies from medicinal plants in Africa and the noticeable research outcomes at current. The study also provided perspectives for future research, pharmaceutical companies, policy makers, research funders, policy makers, and researchers.
The occurrence of monoclinic jarosite in natural environments
Authors: Whitworth Anne J. , Brand Helen E.A. , Wilson Siobhan A. , Grey Ian E. , Stephen Natasha R. , Gozukara Yesim , Frierdich Andrew J. 
Published: April 2022

AbstractJarosite and related subgroup minerals are of high importance in mineral processing, as sources and sinks for metals and acidity in the environment, and they have the potential to preserve elemental and isotopic biomarkers relevant to the search for life in the solar system. The crystal structures and chemistry of jarosite minerals affect their stability and reactivity and thus the roles they play in natural and engineered systems. Rhombohedral symmetry has been documented in natural and synthetic jarosites, whereas monoclinic symmetry has only been documented in synthetic jarosites. This research reports the occurrence of monoclinic symmetry in a natural natrojarosite sample investigated using synchrotron powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), and electron backscatter diffraction (EBSD). Splitting of several rhombohedral PXRD peaks (e.g., 012, 027, and 033) into pairs of peaks was observed, with the magnitude of the splitting and the relative intensities of the pairs of peaks being almost identical to those reported for synthetic monoclinic jarosite. Rietveld refinement with room-temperature PXRD data shows an ordering of iron-site vacancies on the Fe1 site consistent with monoclinic symmetry, space group C2/m. Conversion of monoclinic unit-cell parameters into pseudo-hexagonal unit-cell parameters, specifically β′, also supports the use of a monoclinic model to describe the natrojarosite structure. Structural analysis with increasing temperature is supportive of the thermal evolution previously described for synthetic monoclinic jarosite samples, with some indications of subtle differences between synthetic and natural materials including slower rates of thermal expansion and absence of FeOHSO4 peaks for natural monoclinic jarosite. EBSD provides insight into the spatial–structural variation within the hand specimen from which the natrojarosite was sampled, demonstrating that there are areas of unambiguous monoclinic symmetry, but others where both monoclinic and rhombohedral natrojarosite coexist. The results of this study suggest that monoclinic symmetry in natural jarosites may be more prevalent than previous studies suggest. Monoclinic symmetry in jarosites is identifiable by an ordering of iron-site vacancies on the Fe1 site, splitting of specific rhombohedral XRD peaks into pairs of peaks, and an increase in jarosite symmetry (i.e., from monoclinic to rhombohedral) during heating. The splitting of peaks in monoclinic jarosites can be subtle so it is recommended that high-resolution XRD data are collected when studying the crystal structure of jarosites.
Tourmaline and zircon trace the nature and timing of magmatic-hydrothermal episodes in granite-related Sn mineralization: Insights from the Libata Sn ore field
Authors: Vincent Victor I. , Li Huan , Girei Musa B. , Förster Michael W. , Kamaunji Vandi D. 
Published: April 2022

AbstractThe Bin Yauri-Libata polymetallic ore district is a Sn and Au ore-bearing district in the Zuru schist belt, Northwestern Nigeria. The Libata Sn ore field is characterized by a set of cassiterite-bearing hydrothermal veins associated with Neoproterozoic Pan-African granites affected by deformation and low-grade metamorphism. The hydrothermal alteration associated with cassiterite-bearing quartz veins in the Libata deposit includes silicification, albitization, chloritization, and potassic alteration. In this study, geochemical and geochronological data from tourmalines and zircons from Sn-bearing lodes, unmineralized and altered granites is applied to reveal the timing, fluid composition, and source of ore-forming materials for tin mineralization in the Libata ore field. Zircon trace element and Hf isotopes [εHf(t) = +4.37 to +10.85] reveal a mantle-derived source with some crustal contribution for the melts forming the Libata Sn-bearing granites. LA-ICP-MS zircon U-Pb dating constrains the magmatic and hydrothermal ages to 650–646 and 649–646 Ma for the Libata granites. Overlapping zircon εHf(t) and 176Hf/177Hf but distinct 176Lu/177Hf and 176Yb/177Hf ratios from magmatic and hydrothermally altered zircons reveal a magmatic source for the hydrothermal fluids which triggered cassiterite deposition in the Libata ore field. Major element chemistry constrain tourmalines from the Libata ore field as schorls that show high alkalis, low-Ca contents, and moderate ☐ values (where ☐ is x-site vacancy). High Li, Zn, and Sn concentrations in tourmaline as well as Li/Sr and Ca-Fe-Mg ratios demonstrate that the tourmaline formed from granite-sourced fluid likely derived from the host Libata granites. Measured δ11B values from the Libata tourmaline range from –15.7‰ to –14.1‰. The δ11B of the mineralizing fluid is estimated to be –13.1 to –11.9‰ for the Libata tourmalines at 400–500 °C and overlaps with averages from fractionated granites worldwide. Therefore, our data show that tourmaline and zircon are useful tracers of magmatic-hydrothermal evolution in rare-metal-bearing granite systems.
Mutational Analysis of Interleukin-11 and its Consequences on Cancer and
COVID-19 Related Cytokine Storm -An Extensive Molecular Dynamics
Study
Authors: Ray Sujay , Luharuka Shreya 
Published: April 2022

Background:
Interleukin-11 is a pleiotropic cytokine that is known to play an important
role in the progression of various forms of cancer by modulating the survival and proliferation of
tumour cells. IL11 also demonstrates a structural homology to IL6, the predominant cytokine
involved in COVID-19. This makes IL11 a potential therapeutic target in both diseases.

Objective:
This study aimed to evaluate the impact of the two-point mutations, R135E and R190E,
on the stability of IL11 and their effect on the binding affinity of IL11 with its receptor IL11Rα. It is
a molecular level analysis based on the existing experimental validation.

Method:
Computer-aided drug designing techniques, such as molecular modelling, molecular
docking, and molecular dynamics simulations, were employed to determine the consequential
effects of the two-point mutations.

Results:
Our analysis revealed that the two mutations led to a decrease in the overall stability of
IL11. This was evident by the increased atomic fluctuations in the mutated regions as well as the
corresponding elevation in the deviations seen through RMSD and Rg values. It was also
accompanied by a loss in the secondary structural organisation in the mutated proteins. Moreover,
mutation R135E led to an increase in the binding affinity of IL11 with IL11Rα and the formation of
a more stable complex in comparison to the wild-type protein with its receptor.

CONCLUSION:
Mutation R190E led to the formation of a less stable complex than the wild-type,
which suggests a decrease in the binding affinity between IL11 and IL11Rα.
miR-638: A Promising Cancer Biomarker with Therapeutic Potential
Authors: Hasheminasabgorji Elham , Mishan Mohammad Amir , Tabari Mohammad Amin Khazeei , Bagheri Abouzar 
Published: April 2022

Background:
There is an unmet need to improve the diagnosis of cancer
with precise treatment strategies. Therefore, more powerful diagnostic, prognostic, and
therapeutic biomarkers are needed to overcome tumor cells. microRNAs (miRNAs,
miRs), as a class of small non-coding RNAs, play essential roles in cancer through the
tumor-suppressive or oncogenic effects by post-transcriptional regulation of their targets.
Many studies have provided shreds of evidence on aberrantly expressed miRNAs in
numerous cancers and have shown that miRNAs could play potential roles as
diagnostic, prognostic, and even therapeutic biomarkers in patients with cancers.
Findings have revealed that miR-638 over or underexpression might play a critical role in
cancer initiation, development, and progression. However, the mechanistic effects of
miR-638 on cancer cells are still controversial.

Conclusion:
In the present review, we have focused on the diagnostic, prognostic, and
therapeutic potentials of miR-638 and discussed its mechanistic roles in various types of
cancers.
Potential Neuroprotective Effect of Cannabinoids in COVID-19 Patients
Authors: Cortes-Altamirano José Luis , Yáñez-Pizaña Ariadna , Reyes-Long Samuel , Angélica González-Maciel , Bandala Cindy , Bonilla-Jaime Herlinda , Alfaro-Rodríguez Alfonso 
Published: April 2022

Abstract:
The global pandemic caused by the SARS-CoV-2 virus began in early 2020 and is still
present. The respiratory symptoms caused by COVID-19 are well established. However, neurological
manifestations that may result from direct or indirect neurological damage after SARS-CoV-2
infection have been reported frequently. The main proposed pathophysiological processes leading to
neurological damage in COVID-19 are cerebrovascular disease and indirect inflammatory/
autoimmune origin mechanisms. A growing number of studies confirm that neuroprotective
measures should be maintained in COVID-19 patients. On the other hand, cannabinoids have been
the subject of various studies that propose them as potentially promising drugs in chronic neurodegenerative
diseases due to their powerful neuroprotective potential. In this review, we addresses
the possible mechanism of action of cannabinoids as a neuroprotective treatment in patients infected
by SARS-CoV-2. The endocannabinoid system is found in multiple systems within the body, including
the immune system. Its activation can lead to beneficial results, such as a decrease in viral
entry, a reduction of viral replication, and a reduction of pro-inflammatory cytokines such as IL-2,
IL-4, IL-6, IL-12, TNF-α, or IFN-c through CB2R expression induced during inflammation by
SARS-CoV-2 infection in the central nervous system.
The Synthesis of 2-substituted Benzo[b]furans Catalyzed by Ni/5-Bromo-
2,2’-bipyridine
Authors: Rong Zhou , Yu-qin Li , Yan-li Ding , Xiao-li Qin , Jing Sha , Ping Li , Lu Jin , Huan-huan Wang 
Published: April 2022

Abstract:
A tandem system that enabled the synthesis of 2-substituted benzo[b]furans from 2-
halophenols and aryl acetylenes catalyzed by Ni/5-bromo-2,2’-dipyridine was explored. The protocol
was found effective for one-pot cascade coupling cyclization reaction producing benzo[b]furan
compounds, and heteroaryl substrates were observed to be compatible for this system as well, giving
corresponding products in 20-70% yields.
Diet and Gestational Diabetes Mellitus: A Systematic Review Study
Authors: Alamolhoda Seideh-Hanieh , Zare Elham , Mirabi Parvaneh 
Published: April 2022

Objective:
Diet may have an impact on gestational diabetes mellitus (GDM) development;
nevertheless, controvertible studies have been published. The aim of this study was to provide
evidence from analytical studies on the relationship between diet and GDM development.

Methods:
Following the PRISMA guidelines, ISI Web of Knowledge, PubMed, Google Scholar,
Scopus, Embase, and the Cochrane library were searched for articles published in the English language
from Jan 2005 to Dec 2020. We included observational studies, assessed their risk of bias,
and extracted data on association between diet status and GDM development. Keywords were selected
based on the Mesh terms, which included gestational diabetes mellitus“, “GDM”, “diet,” “nutrition,”
“food,” “dietary pattern which was combined by "OR" and "AND" Boolean operators. Two
reviewers (SHA and PM) independently reviewed abstracts and full-text articles and extracted data.

Results:
Among the 5 articles included, 4 were case-control and one was a cross-sectional study.
Studies have shown that diets with a high intake of saturated fatty acids (more than 10% of total daily
fat intake) and trans fatty acids (more than 1% of total daily fat intake) before and during pregnancy
significantly increase the risk of gestational diabetes mellitus.

Conclusion:
High intake of saturated fat and trans fat before and during pregnancy can disturb glucose
metabolism and increase the risk of GDM, although all of the studies recommend more widespread
observational and clinical trials studies to identify the exact relationship between high saturated
and trans fatty acids intake and GDM.
The Endocannabinoid System as a Biomarker for Diagnostic and Therapeutic
Applications in Depression and Anxiety
Authors: Murillo-Rodríguez Eric , Alcaraz-Silva Jocelyne , Feingold Daniel , Viana-Torre Gerardo , Budde Henning , Imperatori Claudio , Machado Sérgio 
Published: April 2022

Background:
Depression and anxiety belong to a family of mental disturbances that have
increased significantly in recent years. The etiology of both disorders comprises multiple and complex
factors, from genetic background to environmental influence. Since depression and anxiety present severe
symptoms, they represent a greater clinical burden and greater therapeutic difficulty. Currently,
standardized diagnostic procedures for depression and anxiety allow for the addition of further treatments,
including psychotherapy and/or pharmacological intervention, with effective outcomes. However,
further steps should be considered with regard to consideration of the endocannabinoid system’s
role in depression and anxiety.

Objective:
This study aimed to review the evidence from animal research and clinical studies on the role
of cannabinoid receptors, the major endocannabinoids -anandamide (AEA) and 2-arachidonoylglycerol
(2-AG)- and the enzymes related to the synthesis and degradation of these chemicals as putative biomarkers
for diagnostic and therapeutic elements of depression and anxiety.

Method:
This review included the online search, identification, and analysis of articles (basic and
clinical trials) published in English in PubMed linked to the role of cannabinoid receptors, AEA, 2-
AG, and the enzymes associated with the synthesis and degradation of these endocannabinoids in depression
and anxiety.

Results:
The neurobiological relevance of the endocannabinoid system offers genetic or pharmacological
manipulation of this system as a potential strategy for the diagnostic and clinical management of
mood disorders, including depression and anxiety.

Conclusion:
Although the described approach in this review is promising, no solid evidence is yet
available, and along with additional experiments using animal models that mimic human depression
and anxiety, clinical trials are needed to explore the role of the endocannabinoid system’s elements as
well as the anandamide membrane transporter, none of which have been adequately studied in depression
and anxiety.
Factores de riesgo psicosocial y calidad de vida durante el confinamiento por covid-19 en universidades
Authors: Díaz Patiño Diana Gisela , Anaya Velasco Ana , Santoyo Telles Felipe 
Published: April 2022

El objetivo de este trabajo fue identificar los factores de riesgo psicosocial (FRPS) que influyen con más peso en la calidad de vida del personal de universidades y las características sociodemográficas y laborales que diferencian la percepción de los FRPS después de 15 meses de confinamiento por la pandemia de la covid-19. Se trató de un estudio cuantitativo, transversal y explicativo. La muestra fue no probabilística por conveniencia e incluyó 156 colaboradores de universidades del centro de México. Los participantes respondieron en línea la Guía de referencia III y la Guía de referencia V de la Norma Oficial Mexicana 035 de la Secretaría del Trabajo y Previsión Social, así como el cuestionario CVRS, Short Form-36. Entre los resultados, destaca que 57.7 % de la muestra reportó FRPS en niveles medio, alto y muy alto. La vitalidad fue la subescala peor evaluada (M = 65.3); modelos de regresiones por pasos mostraron que la interferencia trabajo-familia (ITF) explicó la vitalidad con 19 % de la varianza (que se incrementó a 23 % al incluir la violencia). Las características sociodemográficas y laborales vinculadas con una mayor percepción de riesgo fueron: edad de 40 a 49 años, estado civil divorciado, grado de maestría, puesto de profesor de tiempo completo y contrato por tiempo indeterminado. La baja vitalidad explicada por la ITF puede ser resultado del largo periodo de teletrabajo no planificado, que parece afectar más a los adultos en edad media.
Percepción estudiantil universitaria de los cursos en línea implementados por contingencia covid-19. Un modelo de ecuaciones estructurales
Authors: Cano Ibarra Salustia Teresa , De la Garza Carranza María Teresa , González Farías José Porfirio , Galván Morales Patricia 
Published: April 2022

El objetivo de esta investigación fue validar el modelo de percepción de estudiantes universitarios sobre la educación en línea que se desarrolló de manera emergente por la situación de pandemia de covid-19. Se trató de un estudio cuantitativo que incluyó un análisis factorial exploratorio (AFE), el cual arrojó tres factores que explican 71 % de la varianza. La consistencia interna de la escala fue adecuada: un alfa de Cronbach de 0.938. Con la finalidad de ratificar el modelo obtenido en el AFE, se llevó a cabo un análisis factorial confirmatorio (AFC) en el que participaron 595 estudiantes de licenciatura del Tecnológico Nacional de México en Celaya divididos en dos grupos. Los resultados indican que el modelo de ecuaciones estructurales final cumple con todos los índices de ajuste y, por ende, que el instrumento final de medición es estable. A partir del modelo validado, se pudo asegurar que, según la percepción de los estudiantes, no se tuvieron grandes problemas en adaptarse a los cursos en línea y no se detectaron problemas graves de conectividad y tecnología, pero extrañan la interacción con profesores y compañeros. Además, manifestaron que la manera en que el profesor diseñe y desarrolle el curso es fundamental para el logro de su éxito académico y consideraron que la retroalimentación del profesor es una acción muy valiosa que fortalece el conocimiento.
What Keeps Elderly Indonesians Working?
Authors: Putri Elfisa , Sari Dyah Wulan 
Published: April 2022

The era of the baby boom and the improvement in the quality of life brought the Indonesian population to an aging phase. The increasing elderly population in Indonesia is not in line with the labor force participation rate of the elderly which tends to stagnant and decline based on BPS data from 2003 to2019. This study aims to examine the determinants of the participation of the elderly to work, not only from the supply side but also from the demand side of the labor market that has never been studied in the Indonesian elderly. We use the 2018 Susenas and the 2018 Podes by Badan Pusat Statistik (BPS). We used logistic regression to analyze the variables that drive the elderly to work. From the results of the study, it is known that with a confidence level of 1 percent, poverty status, the distance to urban centers (access to work) and village industrial structure (with the agricultural sector) plays a role in increasing the opportunities for the elderly to work. While the living arrangement, age, education, and ownership of pensions contribute otherwise.There is a corrigendum for this article: https://journals.ums.ac.id/index.php/JEP/article/view/16187
Attempts to overcome the "death of God" by "irreligious Christianity": the idea of the worldliness of the Transcendent as the basis for creating a new anti-tradition.
Authors: Lepeshkin Dmitrii Germanovich 
Published: April 2022

The subject of the research is the experience of building a non-religious and pseudo-religious faith as a new Christian anti-tradition. The object of research is post–secularism as a phenomenon of modernity. Comparative, descriptive and content analysis served as the methodological basis of the study. The idea of F.Nietzsche's "death of God" gave rise to a natural backlash from the bearers of religiosity, those for whom the existence of God is a reality. However, this answer was twofold. On the one hand, traditional apologetic polemics. But on the other hand, an attempt to rethink Christianity itself in the conditions of a "grown-up" world, the beginning of which, in many ways, was laid by Dietrich Bonhoeffer. But how justified is such an answer and will an attempt to "revise" Christian values lead to their reduction and then oblivion? The following main conclusions were made. Protestant theological thought in the middle of the last century made a number of attempts to "adapt" Christianity to the realities of modernity. Dietrich Bonhoeffer put forward the idea of an adult world that has outgrown religion, and Thomas Altitzer laid the foundation for the "theology of the death of God", which makes Christianity irreligious at all. Such ideas desacralize the very idea of the Transcendent. The appearance of openly parodic pseudo-religious constructs and their partial recognition by modern society finally opens up the prospect of the ultimate profanation of the Transcendent due to the loss of interest in Its search, the reason for which was largely the attempts of confessional thought to solve the problem of the "death of God" through the secularization of faith, which, first of all, means the rejection of Tradition and God as incomprehensible The absolute. Such a denial of Tradition and with it the Transcendent, in fact, speaks not about overcoming the "barriers" of religiosity, but on the contrary, about building a new isolation. We can talk not only about the beginning of the "death" of the tradition, which is reborn into an anti-tradition, but also about the futility of "irreligious faith" and "atheistic Christianity" in general.