bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurobiological sensitivity to unpredictable threat and familial risk for the internalizing and externalizing spectra in adolescents
Authors: Beatty Clare C. , Ferry Rachel A. , Eaton Nicholas R. , Klein Daniel N. , Nelson Brady D. 
Published: August 2022

AbstractBackgroundAdolescence is a key developmental period for the emergence of psychiatric disorders. However, there is still no consensus on the core mechanisms of dysfunction in youth. Neurobiological sensitivity to unpredictable threat has been associated with several psychiatric disorders in adults. The present study examined adolescent defensive motivation (startle reflex) and attention (event-related potentials) in anticipation of unpredictable threat in relation to both adolescent and maternal (i.e. familial risk) internalizing and externalizing spectra.MethodsThe sample included 395 15-year-old adolescents and their biological mothers. Adolescent startle potentiation and probe P300 suppression (indicating increased attention to threat) were measured in anticipation of predictable and unpredictable threat. Adolescent and maternal lifetime history of psychiatric disorders were assessed via semi-structured diagnostic interviews, and confirmatory factor analysis was used to model internalizing and externalizing spectra.ResultsThe adolescent internalizing spectrum was positively associated with adolescent startle potentiation and probe P300 suppression to unpredictable threat. Conversely, the adolescent externalizing spectrum was negatively associated with adolescent P300 suppression to unpredictable threat. The maternal internalizing spectrum was positively associated with adolescent startle potentiation to unpredictable threat and P300 suppression to both predictable and unpredictable threat. The maternal externalizing spectrum was negatively associated with adolescent startle potentiation to unpredictable threat and P300 suppression to both predictable and unpredictable threat. Adolescent and maternal internalizing and externalizing spectra were independently related to adolescent startle potentiation and P300 suppression.ConclusionsAdolescent neurobiological sensitivity to unpredictable threat is associated with both personal history and familial risk for the internalizing and externalizing spectra.
Revisiting Bavinck on Hegel: Providence, reason, and the unsublatable
Authors: Tseng Shao Kai , Sutanto Nathaniel Gray 
Published: August 2022

AbstractHerman Bavinck's reception of the organic motif has become in recent years the central locus for discussing the means by which the unity of his thought may be recognised. This article provides a critical reading of Bavinck on Hegel on the locus of providence for the purpose of contributing to the ongoing discussion that identifies the unity of Bavinck's thought not in his confessional self in simple opposition against the philosophies of his day, but rather in characterising Bavinck as an eclectic, orthodox and modern theologian. To this end this essay moves in three steps. First, we provide an analysis that showcases the nuanced points of contact between Bavinck and Hegel on providence. Second, the essay homes in on the specific ways in which the two thinkers diverge on the Creator–creature relationship. Finally, we close the essay by sketching the salient dogmatic and philosophical implications of the preceding analysis.
Prevalence and demographic correlates of online grocery shopping: results from a nationally representative survey during the COVID-19 pandemic
Authors: Duffy Emily W , Lo Amy , Hall Marissa G , Taillie Lindsey Smith , Ng Shu Wen 
Published: August 2022

AbstractObjective:To estimate the prevalence of online grocery shopping in a nationally representative sample and describe demographic correlates with online grocery shopping.Design:The Nielsen COVID-19 Shopper Behavior Survey was administered to a subset of Nielsen National Consumer Panel participants in July 2020. We used survey weighted-multivariable logistic regression to examine demographic correlates of having ever online grocery shopped.Setting:Online survey.Participants:18 598 Nielsen National Consumer Panel participants in the USA.Results:Thirty-nine percent of respondents had purchased groceries online, and among prior purchasers, 89 % indicated that they would continue to online grocery shop in the next month. Canned/packaged foods were the most shopped for grocery category online, followed by beverages, fresh foods and lastly frozen foods. In adjusted analyses, younger respondents (39 years or less) were more likely (47 %) to have ever shopped for groceries online than older age groups (40–54 years, 55–64 years and 65+ years) (29 %, 22 % and 23 %, respectively, all P < 0·001). Those with greater than a college degree were more likely to have ever grocery shopped online (45 %) than respondents with some college education (39 %) and with a high school education or less (32 %) (both P < 0·001). Having children, having a higher income and experiencing food insecurity, particularly among higher income food-insecure households, were also associated with a higher probability of prior online grocery shopping.Conclusions:The COVID-19 pandemic accelerated the transition to online grocery shopping. Future research should explore the nutrition implications of online grocery shopping.
Digitized thought records: a practitioner-focused review of cognitive restructuring apps
Authors: Erhardt Drew , Bunyi John , Dodge-Rice Zoë , Neary Martha , Schueller Stephen M. 
Published: August 2022

Abstract
Mental health (MH) apps can be used as adjunctive tools in traditional face-to-face therapy to help implement components of evidence-based treatments. However, practitioners interested in using MH apps face a variety of challenges, including knowing which apps would be appropriate to use. Although some resources are available to help practitioners identify apps, granular analyses of how faithfully specific clinical skills are represented in apps are lacking. This study aimed to conduct a review and analysis of MH apps containing a core component of cognitive behaviour therapy (CBT) – cognitive restructuring (CR). A keyword search for apps providing CR functionality on the Apple App and Android Google Play stores yielded 246 apps after removal of duplicates, which was further reduced to 15 apps following verification of a CR component and application of other inclusionary/exclusionary criteria. Apps were coded based on their inclusion of core elements of CR, and general app features including app content, interoperability/data sharing, professional involvement, ethics, and data safeguards. They were also rated on user experience as assessed by the Mobile App Rating Scale (MARS). Whereas a majority of the CR apps include most core CR elements, they vary considerably with respect to more granular sub-elements of CR (e.g. rating the intensity of emotions), other general app features, and user experience (average MARS = 3.53, range from 2.30 to 4.58). Specific apps that fared best with respect to CR fidelity and user experience dimensions are highlighted, and implications of findings for clinicians, researchers and app developers are discussed.

Key learning aims

(1)
To identify no-cost mobile health apps that practitioners can adopt to facilitate cognitive restructuring.

(2)
To review how well the core elements of cognitive restructuring are represented in these apps.

(3)
To characterize these apps with respect to their user experience and additional features.

(4)
To provide examples of high-quality apps that represent cognitive restructuring with fidelity and facilitate its clinical implementation.
Quantifying Northern High Latitude Gross Primary Productivity (GPP) Using Carbonyl Sulfide (OCS)
Authors: Kuai Le , Parazoo Nicholas C. , Shi Mingjie , Miller Charles E. , Baker Ian , Bloom Anthony A. , Bowman Kevin , Lee Meemong , Zeng Zhao‐Cheng , Commane Roisin , Montzka Stephen A. , Berry Joe , Sweeney Colm , Miller John B. , Yung Yuk L. 
Published: August 2022

AbstractThe northern high latitude (NHL, 40°N to 90°N) is where the second peak region of gross primary productivity (GPP) other than the tropics. The summer NHL GPP is about 80% of the tropical peak, but both regions are still highly uncertain (Norton et al. 2019, https://doi.org/10.5194/bg-16-3069-2019). Carbonyl sulfide (OCS) provides an important proxy for photosynthetic carbon uptake. Here we optimize the OCS plant uptake fluxes across the NHL by fitting atmospheric concentration simulation with the GEOS‐CHEM global transport model to the aircraft profiles acquired over Alaska during NASA's Carbon in Arctic Reservoirs Vulnerability Experiment (2012–2015). We use the empirical biome‐specific linear relationship between OCS plant uptake flux and GPP to derive the six plant uptake OCS fluxes from different GPP data. Such GPP‐based fluxes are used to drive the concentration simulations. We evaluate the simulations against the independent observations at two ground sites of Alaska. The optimized OCS fluxes suggest the NHL plant uptake OCS flux of −247 Gg S year−1, about 25% stronger than the ensemble mean of the six GPP‐based OCS fluxes. GPP‐based OCS fluxes systematically underestimate the peak growing season across the NHL, while a subset of models predict early start of season in Alaska, consistent with previous studies of net ecosystem exchange. The OCS optimized GPP of 34 PgC yr−1 for NHL is also about 25% more than the ensembles mean from six GPP data. Further work is needed to fully understand the environmental and biotic drivers and quantify their rate of photosynthetic carbon uptake in Arctic ecosystems.
Spatial and Temporal Variability of Atlantic Water in the Arctic From 40 Years of Observations
Authors: Richards Alice E. , Johnson Helen L. , Lique Camille 
Published: August 2022

AbstractAtlantic Water (AW) is the largest reservoir of heat in the Arctic Ocean, isolated from the surface and sea ice by a strong halocline. In recent years, AW shoaling and warming are thought to have had an increased influence on sea ice in the Eurasian Basin. In this study, we analyze 59,000 profiles from across the Arctic from the 1970s to 2018 to obtain an observationally based pan‐Arctic picture of the AW layer, and to quantify temporal and spatial changes. The potential temperature maximum of the AW (the AW core) is found to be an easily detectable, and generally effective metric for assessments of AW properties, although temporal trends in AW core properties do not always reflect those of the entire AW layer. The AW core cools and freshens along the AW advection pathway as the AW loses heat and salt through vertical mixing at its upper bound, as well as via likely interaction with cascading shelf flows. In contrast to the Eurasian Basin, where the AW warms (by approximately 0.7°C between 2002 and 2018) in a pulse‐like fashion and has an increased influence on upper ocean heat content, AW in the Canadian Basin cools (by approximately 0.1°C between 2008 and 2018) and becomes more isolated from the surface due to the intensification of the Beaufort Gyre. These opposing AW trends in the Eurasian and Canadian Basins of the Arctic over the last 40 years suggest that AW in these two regions may evolve differently over the coming decades.
Alteration at the Base of the Siccar Point Unconformity and Further Evidence for an Alkaline Provenance at Gale Crater: Exploration of the Mount Sharp Group, Greenheugh Pediment Cap Rock Contact With APXS
Authors: Thompson L. M. , Spray J. G. , O’Connell‐Cooper C. , Berger J. A. , Yen A. , Gellert R. , Boyd N. , McCraig M. A. , VanBommel S. J. 
Published: August 2022

AbstractChemical data acquired by Curiosity's Alpha Particle X‐ray Spectrometer during examination of the contact between the upper Mount Sharp group and overlying Stimson formation sandstones at the Greenheugh pediment reveal compositional similarities to rocks encountered earlier in the mission. Mount Sharp group strata encountered below the Basal Siccar Point group unconformity at the base and top of the section, separated by >300 m in elevation, have distinct and related compositions. This indicates enhanced post‐depositional fluid flow and alteration focused along this contact. Sandstone targets exposed immediately above the unconformity have basaltic compositions consistent with previously encountered eolian Stimson formation sandstones, except at the contact, where they show the addition of S. Resistant sandstone outcrops above the contact have higher K, Mn, and Na and lower Ni concentrations that primarily reflect changes in provenance. They are compositionally related to cap rock float blocks encountered as Curiosity climbed through the Mount Sharp group, and Bradbury group sandstone outcrops. The higher K, pediment sandstones are interpreted to have a similar provenance to some Bradbury group sandstones, further evidence for widespread, alkaline source rock within and/or in the vicinity of Gale crater. The Bradbury and Siccar Point groups may both be younger than the Mount Sharp group. Alternatively, an alkaline source area in and around Gale crater has been eroded by both water and wind at different times (both before and after deposition of the Mount Sharp group), during the evolution of the crater and its infill.
Exploring the Impact of Landscape Ecological Risk on Water Quality in the Danjiangkou Reservoir, China
Authors: Cao Zhenxiu , Wan Bo , Xiao Yuhuang , Wu Minghui , Tan Xiang , Zhang Quanfa , Wang Dezhi 
Published: August 2022

AbstractEvaluating the spatial‐temporal dynamics in ecological risk and understanding its impact on water quality in reservoirs could optimize watershed land use and protect reservoir water quality. However, this impact remains elusive due to the lack of long‐term field data, the heterogeneity of land use, and scale effects. Therefore, Danjiangkou Reservoir area was selected as the study area, where rapid urban expansion and ecological conservation and restoration measures have significantly changed the ecological environment, altering the water quality. We investigated the spatial‐temporal changes of land use from 1990 to 2020 and evaluated how landscape ecological risk changed, as well as explored the impact of landscape ecological risk changes on water quality. The landscape ecological risk was calculated by landscape vulnerability and landscape disturbance (based on fragmentation, separation, and fractal dimension). The results indicated that the growth rate of water bodies surged (7.65 km2/a) and cropland experienced an apparent reduction (14.39%) over the past 30 years. These landscape changes decreased ecological risk, especially after the water transfer. The results revealed that the impacts of ecological risk on water quality were better explained at the riparian scale than at the reach and catchment scales. Specifically, the ecological risk was strongly relevant to dissolved oxygen, Turbidity, Cl− and , and moderately correlated to Ca2+ and pH. While it was not correlated with total nitrogen, total phosphorus, and F−, possibly due to the irregular reservoir operations, occasional excessive use of fertilizers, and rock weathering. This study preliminarily discloses the impact of landscape ecological risk on water quality in a basin reservoir and provides a theoretical basis to take measures in advance for the sustainable development of a reservoir basin.
Large‐Scale Traveling Atmospheric and Ionospheric Disturbances Observed in GUVI With Multi‐Instrument Validations
Authors: Bossert Katrina , Paxton Larry J. , Matsuo Tomoko , Goncharenko Larisa , Kumari Komal , Conde Mark 
Published: August 2022

AbstractThis study presents multi‐instrument observations of persistent large‐scale traveling ionosphere/atmospheric disturbances (LSTIDs/LSTADs) observed during moderately increased auroral electrojet activity and a sudden stratospheric warming in the polar winter hemisphere. The Global Ultraviolet Imager (GUVI), Gravity field and steady‐state Ocean Circulation Explorer, Scanning Doppler Imaging Fabry–Perot Interferometers, and the Poker Flat Incoherent Scatter Radar are used to demonstrate the presence of LSTIDs/LSTADs between 19 UT and 5 UT on 18–19 January 2013 over the Alaska region down to lower midlatitudes. This study showcases the first use of GUVI for the study of LSTADs. These novel GUVI observations demonstrate the potential for the GUVI far ultraviolet emissions to be used for global‐scale studies of waves and atmospheric disturbances in the thermosphere, a region lacking in long‐term global measurements. These observations typify changes in the radiance from around 140 to 180 km, opening a new window into the behavior of the thermosphere.
Improving Surface Wind Speed Forecasts Using an Offline Surface Multilayer Model With Optimal Ground Forcing
Authors: Feng Jin , Huang Xiang‐Yu , Li Yanjie 
Published: August 2022

AbstractAn essential task of numerical weather prediction (NWP) is accurate surface wind speed prediction. However, current NWP models contain significant systematic errors due in part to indeterminate ground forcing (GF). This study considers an optimal virtual GF (GFo) derived by training observed and simulated data sets of 10‐m wind speeds (WS10) for summer and winter. The GFo is added to an offline surface multilayer model (SMM) to revise predictions of WS10 in China by the Weather Research and Forecasting model (WRF). This revision is a data‐based optimization under physical constraints. It reduces WS10 errors and offers wide applicability. The resulting model outperforms two purely physical forecasts (the original WRF forecast and the SMM with physical GF parameterized using urban, vegetation, and subgrid topography) and two purely data‐based revisions (i.e., multilinear regression and multilayer perceptron). Compared with the original WRF forecasting, using the GFo scheme reduces the root mean square error in WS10 across China by 25% in summer and 32% in winter. The frontal area index of GFo indicates that it includes both the effects of indeterminate GF and other possible complex physical processes associated with WS10.
Schelkunoff Formulation of the Sommerfeld Integral for the Hertzian Dipole Located in the Vicinity of Cylindrical Structures
Authors: Shaikh Tazeen , Ghosh Bratin , Bhattacharya Dhrubajyoti , Sarabandi Kamal 
Published: August 2022

AbstractA numerical integration of the Sommerfeld integral is performed using the Schelkunoff formulation for cylindrical media. The Schelkunoff kernel for cylindrical media involves higher order modified Bessel functions with azimuthal summation over higher order modes. As such, the convergence characteristics of the cylindrical integral kernel are strongly dependent on complex linear combinations of higher order Bessel/Hankel/modified Bessel functions, compared to the case of the planar media where only a single Bessel/modified Bessel function of zeroth order is present. Two cylindrical configurations are analyzed using the new formulation, viz. a conducting cylinder and a dielectric‐coated conducting cylinder. The branch‐point singularity in the first configuration is removed using the angular transformation for the Sommerfeld/Schelkunoff formulations. A path deformation technique is used for the second configuration to address the problem of poles and branch‐point singularities on the real axis of integration. The in‐depth analysis of the cylindrical kernels and the integrals with variation in the location of the observation point clearly bring out the relative merits of both formulations for the cylindrical configurations, with the TE/TM coupling for the coated cylinder considered.
Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion
Authors: Lauder Sarah N. , Smart Kathryn , Bart Valentina M. T. , Pires Ana , Scott Jake , Milutinovic Stefan , Godkin Andrew , Vanhaesebroeck Bart , Gallimore Awen 
Published: August 2022

Abstract
Background
Recent studies have demonstrated that blocking the PI3Kδ signalling enzyme (by administering a small molecule inhibitor, PI-3065) can potently improve the anti-tumour T-cell response through direct inhibition of Tregs. This treatment also has a negative impact on MDSC numbers but the primary mechanism driving this effect has remained unclear.

Methods
The 4T1 breast cancer mouse model was used in combination with PI-3065 to gain insights into the effect of PI3Kδ inhibition on MDSCs.

Results
PI-3065 treatment resulted in a concomitant reduction in MDSC expansion and tumour size. However, targeting Tregs independent of PI-3065 was also associated with reduced tumour volume and MDSC numbers. Surgical removal of tumours resulted in a rapid and significant decline in MDSC numbers, whilst ex vivo studies using cells from PI-3065-treated mice demonstrated no direct effect of the inhibitor on MDSC activity.

Conclusions
Our data suggest that MDSCs are not inhibited directly by PI-3065 treatment but that their reduced recruitment and immunosuppression within the tumour microenvironment is an indirect consequence of PI3Kδ-inhibition-driven tumour control. This indicates that PI3Kδ inhibition drives tumour immunity by breaking down multiple immunosuppressive pathways through both direct mechanisms (on Treg) and indirect mechanisms, secondary to tumour control (on MDSCs).
Transition metal impurities in silicon: computational search for a semiconductor qubit
Authors: Lee Cheng-Wei , Singh Meenakshi , Tamboli Adele C. , Stevanović Vladan 
Published: August 2022

AbstractSemiconductors offer a promising platform for physical implementation of qubits, but their broad adoption is presently hindered by limited scalability and/or very low operating temperatures. Learning from the nitrogen-vacancy centers in diamond, our goal is to find equivalent optically active point defect centers in crystalline silicon, which could be advantageous for their scalability and integration with classical devices. Transition metal (TM) impurities in silicon are common paramagnetic deep defects, but a comprehensive theoretical study of the whole 3d series that considers generalized Koopmans’ condition is missing. We apply the HSE06(+U) method to examine their potential as optically active spin qubits and identify seven TM impurities that have optically allowed triplet–triplet transitions within the silicon band gap. These results provide the first step toward silicon-based qubits with higher operating temperatures for quantum sensing. Additionally, these point defects could lead to spin-photon interfaces in silicon-based qubits and devices for mid-infrared free-space communications.
Accurate large-scale simulations of siliceous zeolites by neural network potentials
Authors: Erlebach Andreas , Nachtigall Petr , Grajciar Lukáš 
Published: August 2022

AbstractThe computational discovery and design of zeolites is a crucial part of the chemical industry. Finding highly accurate while computational feasible protocol for identification of hypothetical siliceous frameworks that could be targeted experimentally is a great challenge. To tackle this challenge, we trained neural network potentials (NNP) with the SchNet architecture on a structurally diverse database of density functional theory (DFT) data. This database was iteratively extended by active learning to cover not only low-energy equilibrium configurations but also high-energy transition states. We demonstrate that the resulting reactive NNPs retain DFT accuracy for thermodynamic stabilities, vibrational properties, as well as reactive and non-reactive phase transformations. As a showcase, we screened an existing zeolite database and revealed >20k additional hypothetical frameworks in the thermodynamically accessible range of zeolite synthesis. Hence, our NNPs are expected to be essential for future high-throughput studies on the structure and reactivity of siliceous zeolites.