bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening and Capability Assessment of Tyrosinase Inhibitors in Isodon excisoides by Ultrafiltration Coupled with UHPLC‐Q‐TOF‐MS and Molecular Docking Technology
Authors: Jia Xinming , Sun Shilin , Zhang Qian , Wang Nan , Yang Mengxin , Jin Yiran , Du Yingfeng 
Published: November 2022

AbstractTyrosinase inhibitors can alleviate the harm to the liver caused by tyrosinase. How to effectively screen out natural tyrosinase inhibitors becomes a focus. In this study, Isodon excisoides was first extracted with the ultrasound optimized by response surface methodology. Then, a method combined ultrafiltration with ultra‐liquid chromatography mass spectrometry (UHPLC/MS) was built to screen and identify tyrosinase inhibitors. The binding energies of active ingredients to tyrosinase were calculated by molecular docking. The reliability of the results was validated by the IC50 of enzyme inhibition assay. As a result, the binding energies of 7 components including excisanin B, lasiokaurin, rabdophyllin G, rabdoserrin B, rabdosin D, rabdosinate and weisiensin were lower than that of resveratrol. It was indicated that these components had high tyrosinase inhibitory activity. The IC50 values of lasiokaurin and excisanin B were 177 and 142 μmol/mL, which were less than that of resveratrol (183 μmol/mL). It showed that this way was simple, rapid, reliable and effective, which provided a new strategy to screen natural bioactive compounds from plants.
When a polyester mesh causes an enterocutaneous fistula, 30 years after its implantation
Authors: Mahjoubi Mohamed Farès , Essid Nada , Rezgui Bochra , Zran Mohamed , Haouet Karim , Ben Moussa Mounir 
Published: November 2022

AbstractDigestive fistula on mesh is an exceptional and late complication of hernioplasty. The type of mesh and its position are often implicated in its occurrence. Clinical presentation is multiform. Morphological examinations are essential to confirm the diagnosis, and the curative treatment remains surgical.
Symptomatic hypoglycemia in a nondiabetic adult female recovering from mild COVID‐19 infection: A case report
Authors: Grover Jayant , Verma Vishesh , Menon Anil , Dorji Thinley 
Published: November 2022

AbstractA 38‐year‐old lady, recently recovered from SARS‐CoV‐2 infection and taking grape seed extract, suffered multiple episodes of severe postprandial hyperinsulinemic hypoglycemia. A careful evaluation ruled out the common etiologies of hypoglycemia and identified grape seed extract consumption as a possible cause. She recovered after stopping the nutritional supplements. In her, hypoglycemia could have resulted from transient beta cell dysfunction associated with SARS‐CoV‐2 infection or proanthocyanidins in the grape seed extract.
A congenital wandering spleen with a large epithelial cyst: A case report
Authors: Lim Youhok , Leng Hour , Lee Chi Hoon , Chhun Vireak , Lee Young Don 
Published: November 2022

AbstractWe present a case of a 21‐year‐old female patient who had a wandering spleen with a large cyst. The celiotomy was performed under the impression of torsion of the wandering spleen and leakage from the splenic cyst. The total splenectomy was performed instead of cystectomy and splenopexy.
Cervical vagal schwannoma, a rare differential of a neck swelling: A case report
Authors: Prajapati Ramesh , Thapa Aakar , Yadav Jayant Kumar , Lama Manik , Shrestha Prakash , KC Ashmita , Gurung Pritam , Pant Basant 
Published: November 2022

AbstractCervical vagal schwannoma is a rare clinical entity that requires a different clinical approach than other neck swellings. Magnetic resonance imaging is the preferred initial diagnostic test. Complications may arise due to vagal stimulation in unsuspecting open biopsies. Surgical excision with perioperative vagal monitoring is recommended for the treatment of vagal schwannomas.
A novel WDR60 variant contributes to a late diagnosis of Jeune asphyxiating thoracic dystrophy in a Chinese patient: A case report
Authors: Zhao Xiangzhong , Sui Aihua , Cui Li , Liu Zhiying , Zhang Ruixiao , Han Yue , Shao Leping 
Published: November 2022

AbstractWe report a Chinese patient with JATD presenting a mild skeletal phenotype and with renal insufficiency as the initial symptom of the disease. A novel homozygous c.2789C>T (p.S930L) variant in the WDR60 gene was identified. Our report will help to improve awareness and diagnosability for this disease.
Distribution‐free predictive inference for partial least squares regression with applications to molecular descriptors datasets
Authors: Lin Youwu , Xu Congcong , Zhou Zhaojun , Shen Liang , Huang Shuai 
Published: November 2022

AbstractIn statistical modeling, partial least squares (PLS) regression is one of the most popular techniques for prediction problems. An important but often overlooked problem is that the estimation of prediction confidence intervals always contains an unobserved response value with a specified probability. Therefore, in the present work, we studied how to estimate prediction intervals in PLS regression without any distributional assumptions on data. First, a recently proposed method, jackknife+, is introduced to PLS regression for uncertainty quantification. Second, a novel approach is developed to construct distribution‐free prediction intervals. Finally, empirical studies on simulations and three real‐world datasets show that the proposed method has better coverage properties than other state‐of‐the‐art methods.
Roles that Organic Ammoniums Play on the Surface of the Perovskite Film: A Review
Authors: Liu Xiaotao , Qiao Yu , Guo Xin 
Published: November 2022

AbstractThe roles of organic ammonium salts (OASs) which are widely used for the surface treatment of the perovskite film, including formation of 2D perovskites, direct surface passiviation, and other effects, have been reviewed. The influencing factors for these roles of OASs are also discussed, which are important for improved efficiency and stability of perovskite solar cells. More information can be found in the Review article by X. Guo and co‐workers. (DOI:10.1002/chem.202203001)
Preparation of N‐2‐Nitrophenylsulfenyl Imino Peptides and Their Catalyst‐Controlled Diastereoselective Indolylation
Authors: Inokuma Tsubasa , Masui Kana , Fukuhara Koki , Yamada Ken‐ichi 
Published: November 2022

AbstractN‐2‐Nitrophenylsulfenyl imino dipeptides bearing various functional groups were successfully prepared by MnO2‐mediated oxidation and then subjected to diastereoselective indolylation. Each diastereomer of the adduct was selectively obtained from the same substrates using the appropriate chiral phosphoric acid catalysts. These transformations would be useful for synthesizing non‐canonical amino acid‐containing peptides as novel drug candidates.
Imidodiphosphorimidates (IDPis): Catalyst Motifs with Unprecedented Reactivity and Selectivity
Authors: Cheng Jun Kee , Xiang Shao‐Hua , Tan Bin 
Published: November 2022

AbstractThe conceptually designed imidodiphosphorimidates (IDPis) have emerged as one of the most potent classes of chiral acid catalysts. They are characterized by enzyme‐like, highly confined active site and high acidity, which underlie their wide‐reaching applications as Brønsted acid catalysts and as precatalysts for silylium Lewis acids. Many carbon‐carbon and carbon‐heteroatom bond formation reactions that were deemed intractable could now be attained with spectacular reactivity and selectivity. Substrates that are small, unbiased and/or possess insufficient reactivity such as simple alkenes could now be engaged. The high structural confinement is particularly invaluable to control stereo‐ and chemoselectivity. The well‐defined steric environment offers unique opportunity to control high‐energy but structurally unbiased cation intermediates such as the norbonyl cations. Beyond practical appeals such as good scalability as well as ease and modularity of preparation, the extremely low pre‐catalyst loadings required to achieve high turnover and stereoselectivity have also come to define a new frontier in organocatalysis.
PROTOCOL: The effectiveness, implementation and cost effectiveness of mentoring programmes in reducing anti‐social, violent and offending behaviour in children aged 17 years and below: A mixed method systematic review
Authors: Lakshminarayanan Monisha , Skinner Guy , Li Jing , Tolan Patrick , Du Bois David , White Howard 
Published: November 2022

AbstractThis is the protocol for a Campbell systematic review. The review will address the following research questions: What is the evidence on the effects of adult mentoring programmes in reducing anti‐social, violent and offending behaviour in children aged under 18 years? Are these effects sustained after the end of mentoring? Which aspects/features of adult mentoring programmes promote the reduction of anti‐social, violent and criminal behaviour in children aged under 18 years? What are the hindering factors/barriers that affect the successful implementation of adult mentoring programmes in children aged under 18 years? What are the supporting factors/facilitators that contribute to the successful implementation of adult mentoring programmes in children aged under 18 years? What is the evidence on programme costs and incremental cost effectiveness? (The incremental (or marginal cost) is the cost of providing the intervention over and above the cost of usual services).
A noninterference trusted dual system security guarantee method based on secure memory
Authors: Hong Yu , Li Yi , Tan Haining 
Published: November 2022

SummaryWith the continuous maturity and development of single hardware security mechanism, it has been widely used in the field of information technology, but the single hardware mechanism has insufficient security guarantee in its own supporting drivers and other key programs. In response to this problem, this article proposes a trusted isolation model based on the noninterference theory and gives a formal proof. The realization is based on the trusted platform control module (TPCM) hardware mechanism by introducing a secure memory bar to provide a way to achieve a trusted dual‐system isolation guarantee. The hardware interface of secure memory module is consistent with that of ordinary memory module, which is widely used. It can improve the security guarantee ability of trusted computing platform, and has a good reference value for the design and application of trusted computing platform equipment.
Identifying the research priorities for schema therapy: A Delphi consensus study
Authors: Pilkington Pamela D. , Younan Rita , Karantzas Gery C. 
Published: November 2022

AbstractDespite the popularity of schema therapy, there exist several important gaps in research on the schema therapy model and its effectiveness. The number of gaps makes it difficult to determine the research areas of the highest strategic priority to advance schema therapy. The objective of this study was to establish consensus among schema therapy clinicians and researchers on the priority areas for future schema therapy research. A panel of experts in schema therapy (43 clinicians and 13 researchers) participated in a Delphi consensus study. The research areas rated were developed by interviewing the founder of schema therapy, Jeffrey Young, conducting a focus group with the executive board of the International Society for Schema Therapy and screening recent reviews on schema therapy for recommendations for future research. The panel rated 81 research areas in terms of priority across three rounds. Nineteen research areas were rated by 75% of the panel as ‘Very high priority’ or ‘High priority’. These priorities reflected four broad themes: (1) schema therapy constructs and measures, (2) the theoretical assumptions underlying schema therapy, (3) schema therapy and theory in relation to different contexts and outcomes and (4) schema therapy effectiveness and mechanisms of change. The findings are important for establishing a clear research agenda for the future of schema therapy.
Industrial accidents: The mediating effect of corporate social responsibility and environmental policy measures
Authors: Caiazza Stefano , Galloppo Giuseppe , Lattanzio Gabriele 
Published: November 2022

AbstractUsing a novel hand‐collected sample including 159 industrial events that occurred between 2000 and 2020, we document that corporate social performance (CSP) generally acts as a halo effect mitigating the stock market drop following these events. These findings, robust to many alternative specifications, provide novel evidence shedding light on how corporate social capital acts as a mitigating device against the consequences of tail events. To the best of our knowledge, this is one of the first studies investigating the mitigation role of CSP in the aftermath of an industrial accident by analyzing a large global sample of industrial incidents. The practical and theoretical implications of our findings are at the bottom of that form of a socially normative corporate force embedded in social trust, smoothing managers' and stakeholders' interests together.
Implementation of class‐E/F3 power amplifiers based on the variations of the MOSFET grading coefficient, built‐in potential and output capacitance along with their roles in MOSFET selectivity
Authors: Abdipour Ashkan , Hayati Mohsen , Grebennikov Andrei 
Published: November 2022

SummaryIn this paper, a theoretical analysis of the class‐E/F3 power amplifier based on the variation of the grading coefficient m1 and its vital role in MOSFET selectivity to operate safely under given design specifications is presented while the nonlinearity of the drain‐to‐source capacitance is considered. Moreover, the importance of Vbi and Cjo in designing the class‐E/F3 amplifier is investigated. To clarify how the grading coefficient m1 and the other mentioned parameters can directly influence the power amplifier performance and also its elements, these MOSFET parameters are considered as the independent variables of the calculated equations and consequently define the horizontal axis of the obtained plots. Accordingly, as the grading coefficient increases, the maximum switch voltage increases and values of the output power and output power capability decline. Moreover, to prove the reliability of the carried‐out analysis in selecting proper MOSFETs, the performances of three amplifier samples utilizing IRF510, IRFZ24N, and 2SK2504 MOSFETs with different grading coefficient m1 and almost similar Vbi and Cjo are studied. Then, by comparing the results of amplifiers with three MOSFETs, IRF510, IRF530, and IRF540, with similar grading coefficient and different values of Vbi and Cjo, the significance of considering the values of Vbi and Cjo is investigated. Eventually, three amplifiers with 2SK2504, IRF510, and IRF530 MOSFETs have been simulated, implemented, and tested and measurement results agreed well with the theoretical and simulation results.
Research on the state of charge estimation method of lithium‐ion batteries based on novel limited memory multi‐innovation least squares method and SDE‐2‐RC equivalent model
Authors: Cao Jie , Wang Shunli , Xie Yanxin , Fernandez Carlos 
Published: November 2022

SummaryBecause of the common data redundancy phenomenon in the current least‐squares parameter identification algorithm and the complex offline parameter identification process, this research innovatively proposes a Limited Memory Multi‐Innovation Least Squares (LM‐MILS) ternary lithium‐ion battery (LIB) parameter identification algorithm that uses a limited set of data to estimate model parameters and attenuates the effects of old data. To improve the parameter fidelity of the equivalent circuit model (ECM) of the LIB, considering that the open‐circuit voltage of the lithium‐ion battery will gradually decrease with the self‐discharge when it is not in use, based on a large number of experiments, a model considering the self‐discharge of the LIB is constructed. The experimental results show that the self‐discharge effect‐2‐RC (SDE‐2‐RC) model can achieve higher accuracy in simulating the working state of the battery and the peak error of the simulated voltage is only 0.04342 V, and the accuracy can reach more than 98.966%. Using LM‐MILS and adaptive Kalman filtering algorithm (AEKF) for the state of charge (SOC) estimation, the results show that the algorithm has a fast convergence speed and strong tracking performance. The maximum SOC estimation errors in HPPC, DST, and BBDST three operating conditions are 0.00929, 0.01273, and 0.01002, respectively. The fluctuation range is small, and the maximum estimation error is less than 2%, which verifies that the improved parameter identification algorithm has good performance in improving the SOC estimation accuracy of LIB.
Hybrid 802.11p‐cellular architecture for NDN‐based VANET
Authors: Aboud Ahmed , Touati Haifa , Hnich Brahim 
Published: November 2022

SummaryVehicular network communications (VANET) face multiple challenges due to their intermittent connections and the rapid changes in their topologies. In recent years, several research efforts have explored the use of content‐centric approaches to alleviate some of these challenges. One of these promising network designs is Named Data Networking (NDN), which has become a valid solution to support VANET applications. However, in the NDN architecture, the main forwarding mechanism for the interest packets is flooding. This forwarding mechanism will result in excessive collisions, which will lead to the broadcast storm problem. In this paper, we propose VC‐NDN: a hybrid and hierarchical Named Data Networking architecture for VANETs. VC‐NDN improves content retrieval efficiency through an adapted NDN‐based communication model. VC‐NDN includes a new interest forwarding scheme to reduce packet collision in the network and an efficient mechanism to support push‐based traffic. Furthermore, to reduce communication costs, VC‐NDN uses two communication technologies in parallel, namely, IEEE 802.11p and cellular communications, while keeping the usage of the cellular network at a minimum level. Finally, to reduce the impact on vehicle mobility, VC‐NDN follows a hierarchical clustering architecture. Specifically, a density‐based clustering algorithm is designed to create and maintain stable clusters with multihop communication capability. Our performance study shows that VC‐NDN outperforms the basic VNDN solutions in terms of data retrieval delay and packet delivery ratio while minimizing the usage of the cellular network.
The relationship between Alzheimer's‐related brain atrophy patterns and sleep macro‐architecture
Authors: Weihs Antoine , Frenzel Stefan , Garvert Linda , Kühn Luise , Wittfeld Katharina , Ewert Ralf , Fietze Ingo , Penzel Thomas , Stubbe Beate , Szentkirályi András , Wulms Niklas , Völzke Henry , Grabe Hans J. 
Published: November 2022

AbstractIntroductionSleep is increasingly recognized as a major risk factor for neurodegenerative disorders such as Alzheimer's disease (AD).MethodsUsing an magnetic resonance imaging (MRI)–based AD score based on clinical data from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) case‐control cohort, we investigated the associations between polysomnography‐based sleep macro‐architecture and AD‐related brain atrophy patterns in 712 pre‐symptomatic, healthy subjects from the population‐based Study of Health in Pomerania.ResultsWe identified a robust inverse association between slow‐wave sleep and the AD marker (estimate: −0.019; 95% confidence interval: −0.03 to −0.0076; false discovery rate [FDR] = 0.0041), as well as with gray matter (GM) thicknesses in typical individual cortical AD‐signature regions. No effects were identified regarding rapid eye movement or non–rapid eye movement (NREM) stage 2 sleep, and NREM stage 1 was positively associated with GM thickness, mainly in the prefrontal cortical regions.DiscussionThere is a cross‐sectional relationship between AD‐related neurodegenerative patterns and the proportion of sleep spent in slow‐wave sleep.
Emotional characteristics of socially isolated older adults with MCI using tablet administered NIH toolbox: I‐CONECT study
Authors: Yu Kexin , Wild Katherine , Dowling N. Maritza , Kaye Jeffrey A. , Silbert Lisa C. , Dodge Hiroko H. 
Published: November 2022

AbstractIntroductionExamining the emotional functioning of individuals with mild cognitive impairment (MCI) could help describe their cognitive status and inform the development of interventions. This study compared the emotional characteristics of socially isolated older adults with and without MCI.MethodsWe used baseline data from the Internet‐based Conversational Engagement Clinical Trial. Emotional characteristics were assessed with the National Institutes of Health Toolbox Emotion Battery (NIHTB‐EB). MCI status was determined with a consensus clinical diagnosis.ResultsThis study included 163 participants (mean age = 81.2 years, non‐Hispanic Black = 20.7%, MCI = 52.8%). MCI was associated with higher negative affect and lower psychological well‐being. Non‐Hispanic Black participants scored lower in sadness, higher in positive affect, and higher in meaning and purpose than non‐Hispanic White participants.ConclusionOlder adults with MCI experience more negative emotions and worse psychological well‐being than those with normal cognition. The NIHTB‐EB appears to be a sensitive tool to detect emotional characteristics associated with cognitive decline.
Assessment of the effects of sex, age, and rearing condition on ultrasonic vocalizations elicited by pups during the maternal potentiation paradigm in C57BL/6J mice
Authors: Santana‐Coelho Danielle , Womble Paige D. , Blandin Katherine J. , Pilcher Jacob B. , O'Neill Grace M. , Douglas Leighton A. , Chilukuri Srikhar V. , Tran Doan L. K. , Wiley Taylor A. , Lugo Joaquin N. 
Published: November 2022

AbstractIsolation‐induced ultrasonic vocalizations (USVs) are important to elicit parental retrieval. This behavior is critical for the animal's survival and can be altered in models of developmental disorders. The potentiation of vocalizations in response to reunion with the dam, also called maternal potentiation, has been extensively studied in rats. However, the assessment of this paradigm in mice is scarce. In rats, the potentiation of vocalizations is dependent on rearing conditions. Since mice are the main species used for genetic models of diseases, we aimed to investigate how different factors such as age, sex, and rearing conditions can affect the potentiation of vocalizations in the maternal potentiation paradigm in mice. We carried out experiments using biparental (dam and sire) or uniparental rearing (dam). Pups were tested on postnatal days (PD) 9 or 12. Pups showed increased potentiation in both sexes at PD9 with uniparental rearing. Both rearing conditions and ages changed the repertoire from the first to the second isolation. Spectral parameters were affected by sex, rearing condition and reunion at PD9. At PD12, only duration was altered by reunion. We conclude that the performance of the pups in the maternal potentiation paradigm is dependent on age, sex, and rearing condition.