bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controls on the relative melt rates of debris-covered glacier surfaces
Authors: Miles E S , Steiner J F , Buri P , Immerzeel W W , Pellicciotti F 
Published: April 2022

Abstract
Supraglacial debris covers 7% of mountain glacier area globally and generally reduces glacier surface melt. Enhanced energy absorption at ice cliffs and supraglacial ponds scattered across the debris surface leads these features to contribute disproportionately to glacier-wide ablation. However, the degree to which cliffs and ponds actually increase melt rates remains unclear, as these features have only been studied in a detailed manner for selected locations, almost exclusively in High Mountain Asia. In this study we model the surface energy balance for debris-covered ice, ice cliffs, and supraglacial ponds with a set of automatic weather station records representing the global prevalence of debris-covered glacier ice. We generate 5000 random sets of values for physical parameters using probability distributions derived from literature, which we use to investigate relative melt rates and to isolate the melt responses of debris, cliffs and ponds to the site-specific meteorological forcing. Modelled sub-debris melt rates are primarily controlled by debris thickness and thermal conductivity. At a reference thickness of 0.1 m, sub-debris melt rates vary considerably, differing by up to a factor of four between sites, mainly attributable to air temperature differences. We find that melt rates for ice cliffs are consistently 2–3× the melt rate for clean glacier ice, but this melt enhancement decays with increasing clean ice melt rates. Energy absorption at supraglacial ponds is dominated by latent heat exchange and is therefore highly sensitive to wind speed and relative humidity, but is generally less than for clean ice. Our results provide reference melt enhancement factors for melt modelling of debris-covered glacier sites, globally, while highlighting the need for direct measurement of debris-covered glacier surface characteristics, physical parameters, and local meteorological conditions at a variety of sites around the world.
CrAssphage as an indicator of groundwater-borne pollution in coastal ecosystems
Authors: Threndyle Ryan E , Kurylyk Barret L , Huang Yannan , Johnston Lindsay H , Jamieson Rob C 
Published: April 2022

Abstract
Novel approaches for monitoring coastal water quality changes and identifying associated contaminant source(s) are of growing importance as climate change and population redistribution to coastal zones continue to impact coastal systems. CrAssphage, a virus found in the human gut and shed with fecal matter, is currently gaining popularity as an indicator of human fecal contamination in surface water and groundwater. Here we demonstrate that DNA assays targeting crAssphage genetic fragments can be used to detect pollution from nearshore onsite wastewater treatment systems discharging to the ocean via submarine groundwater discharge. We integrated this novel viral monitoring tool into a field study that characterized the physical hydrogeology (hydraulic gradients, hydraulic conductivity, and seepage fluxes) and surface water and groundwater quality at a study site on the north shore of Nova Scotia, Canada. Increased use of onsite wastewater treatment systems during the summer cottage season coincided with widespread detections of crAssphage in submarine groundwater discharge (4/4 samples) and coastal surface waters (3/8 samples). Conversely, classical fecal pollution indicators based on bacterial targets (Escherichia coli and human-specific Bacteroidales genetic marker (HF183)) were sparsely detected in the samples in the coastal environment (2/12 E. coli samples, 0/12 HF183 samples), likely due to greater attenuation of bacterial contaminants within the subsurface environments. Results from this first application of crAssphage in coastal groundwater contribute to a growing body of research reporting the application of this emerging tracer in various environments impacted by sewage pollution sources.
I-design terahertz microfluidic chip for attomole-level sensing
Authors: Serita Kazunori , Kobatake Satoshi , Tonouchi Masayoshi 
Published: April 2022

Abstract
We developed a nonlinear optical crystal-based compact terahertz (THz)-microfluidic chip with several I-design meta-atoms for attomole (amol)-level sensing of trace amounts of solution samples. The I-design meta-atom consists of a metallic strip with a micometer-sized gap sandwiched by other metallic strips. It is periodically arrayed in a row of 1 × 5 units. A point THz source locally generated by optical rectification at the irradiation spot of a femtosecond-pulse laser beam induces a tightly confined electric-field mode at the gap regions and modifies the resonance frequency when a microchannel fabricated along the space between the metallic strips is filled with solutions. Using this chip, we could detect minute changes in the concentration of trace amounts of ethanol- and glucose-water solutions and mineral water by measuring the shift in the resonance frequencies. We succeeded in detecting 472 amols of solutes in solutions less than 100 picoliters using an effective sensing area of 0.10 λ
THz × 0.57 λ
THz, which indicates an improvement of approximately one order of magnitude compared to the performance of existing chips. This technique compactifies THz-microfluidic chips with high sensitivity and would accelerate the development of microfluidics integrated with THz technology, such as lab-on-a-chip devices and THz micro total analysis systems.
The why and how of sunken stomata: does the behaviour of encrypted stomata and the leaf cuticle matter?
Authors: Šantrůček Jiří 
Published: April 2022

Abstract

Background
Stomatal pores in many species are separated from the atmosphere by different anatomical obstacles produced by leaf epidermal cells, especially by sunken stomatal crypts, stomatal antechambers and/or hairs (trichomes). The evolutionary driving forces leading to sunken or ‘hidden’ stomata whose antechambers are filled with hairs or waxy plugs are not fully understood. The available hypothetical explanations are based mainly on mathematical modelling of water and CO2 diffusion through superficial vs. sunken stomata, and studies of comparative autecology. A better understanding of this phenomenon may result from examining the interactions between the leaf cuticle and stomata and from functional comparisons of sunken vs. superficially positioned stomata, especially when transpiration is low, for example at night or during severe drought.

Scope
I review recent ideas as to why stomata are hidden and test experimentally whether hidden stomata may behave differently from those not covered by epidermal structures and so are coupled more closely to the atmosphere. I also quantify the contribution of stomatal vs. cuticular transpiration at night using four species with sunken stomata and three species with superficial stomata.

Conclusions
Partitioning of leaf conductance in darkness (gtw) into stomatal and cuticular contributions revealed that stomatal conductance dominated gtw across all seven investigated species with antechambers with different degrees of prominence. Hidden stomata contributed, on average, less to gtw (approx. 70 %) than superficial stomata (approx. 80 %) and reduced their contribution dramatically with increasing gtw. In contrast, species with superficial stomata kept their proportion in gtw invariant across a broad range of gtw. Mechanisms behind the specific behaviour of hidden stomata and the multipurpose origin of sunken stomata are discussed.
Shifting-corrected regularized regression for 1HNMR metabolomics identification and quantification
Authors: Vu Thao , Xu Yuhang , Qiu Yumou , Powers Robert 
Published: April 2022

SummaryThe process of identifying and quantifying metabolites in complex mixtures plays a critical role in metabolomics studies to obtain an informative interpretation of underlying biological processes. Manual approaches are time-consuming and heavily reliant on the knowledge and assessment of nuclear magnetic resonance (NMR) experts. We propose a shifting-corrected regularized regression method, which identifies and quantifies metabolites in a mixture automatically. A detailed algorithm is also proposed to implement the proposed method. Using a novel weight function, the proposed method is able to detect and correct peak shifting errors caused by fluctuations in experimental procedures. Simulation studies show that the proposed method performs better with regard to the identification and quantification of metabolites in a complex mixture. We also demonstrate real data applications of our method using experimental and biological NMR mixtures.
Estimation of sparse functional quantile regression with measurement error: a SIMEX approach
Authors: Tekwe Carmen D , Zhang Mengli , Carroll Raymond J , Luan Yuanyuan , Xue Lan , Zoh Roger S , Carter Stephen J , Allison David B , Geraci Marco 
Published: April 2022

Summary
Quantile regression is a semiparametric method for modeling associations between variables. It is most helpful when the covariates have complex relationships with the location, scale, and shape of the outcome distribution. Despite the method’s robustness to distributional assumptions and outliers in the outcome, regression quantiles may be biased in the presence of measurement error in the covariates. The impact of function-valued covariates contaminated with heteroscedastic error has not yet been examined previously; although, studies have investigated the case of scalar-valued covariates. We present a two-stage strategy to consistently fit linear quantile regression models with a function-valued covariate that may be measured with error. In the first stage, an instrumental variable is used to estimate the covariance matrix associated with the measurement error. In the second stage, simulation extrapolation (SIMEX) is used to correct for measurement error in the function-valued covariate. Point-wise standard errors are estimated by means of nonparametric bootstrap. We present simulation studies to assess the robustness of the measurement error corrected for functional quantile regression. Our methods are applied to National Health and Examination Survey data to assess the relationship between physical activity and body mass index among adults in the United States.
Directed evolution as an approach to increase fructose utilization in synthetic grape juice by wine yeast AWRI 796
Authors: Walker Michelle E , Watson Tommaso L , Large Christopher R L , Berkovich Yan , Lang Tom A , Dunham Maitreya J , Formby Sean , Jiranek Vladimir 
Published: April 2022

AbstractIn winemaking, slow or stuck alcoholic fermentation can impact processing efficiency and wine quality. Residual fructose in the later stages of fermentation can leave the wine ‘out of specification’ unless removed, which requires reinoculation or use of a more fructophilic yeast. As such, robust, fermentation efficient strains are still highly desirable to reduce this risk. We report on a combined EMS mutagenesis and Directed Evolution (DE) approach as a ‘proof of concept’ to improve fructose utilization and decrease fermentation duration. One evolved isolate, Tee 9, was evaluated against the parent, AWRI 796 in defined medium (CDGJM) and Semillon juice. Interestingly, Tee 9 exhibited improved fermentation in CDGJM at several nitrogen contents, but not in juice. Genomic comparison between AWRI 796 and Tee 9 identified 371 mutations, but no chromosomal copy number variation. A total of 95 noncoding and 276 coding mutations were identified in 297 genes (180 of which encode proteins with one or more substitutions). Whilst introduction of two of these, Gid7 (E726K) or Fba1 (G135S), into AWRI 796 did not lead to the fermentation improvement seen in Tee 9, similar allelic swaps with the other mutations are needed to understand Tee 9’s adaption to CDGJM. Furthermore, the 378 isolates, potentially mutagenized but with the same genetic background, are likely a useful resource for future phenotyping and genome-wide association studies.
Changing Relationships Between Social Contact, Social Support, and Depressive Symptoms During the COVID-19 Pandemic
Authors: Ang Shannon 
Published: April 2022

Abstract

Objectives
Given the longstanding consensus that social contact can promote older adult well-being, many have focused on how social contact changed during the pandemic. Less is known, however, about whether the link between social contact and health changed during the pandemic. This study sought to understand how associations between social contact, social support, and depressive symptoms changed during the coronavirus disease 2019 (COVID-19) pandemic.

Methods
Data from 2 waves of the Health and Retirement Study were used. Respondents reported both virtual and in-person social contact, as well as perceived positive and negative social support. Path models were used to estimate relationships between social contact, social support, and depressive symptoms. Bootstrapping was used to estimate the change in associations between 2016 and 2020.

Results
Estimates show that associations between positive social support and depressive symptoms, as well as between in-person social contact and depressive symptoms, attenuated during the pandemic. Virtual social contact played a relatively minor role in determining outcomes such as social support and depressive symptoms, compared to in-person social contact.

Discussion
Findings suggest that researchers and policymakers should not only focus on the changing quantity of social interactions when events such as the COVID-19 pandemic happen, but also the changing content and efficacy of the social interactions that remain.
Geophysical inversions on unstructured meshes using non-gradient based regularization
Authors: Zhang Yi , Xu Yixian , Yang Bo , Mooney Walter D , Wang Feng 
Published: April 2022

SUMMARYGeophysical inverse problems are commonly ill-posed and require proper regularization to gain acceptable solutions. Adopting constraints on the smoothness and/or specified structures of an inverted geophysical model requires the implementation of regularization terms when either structured or unstructured meshes are used. Spatial gradients of the model parameters along axial or arbitrary directions are thus required. However, the calculation of spatial gradients on unstructured meshes is not straightforward since the interfaces between adjacent model cells (i.e. common edges or common faces) are orientated individually and usually are not perpendicular to the axial directions. Depending on the algorithm used, an uneven performance of the regularization is observed on unstructured meshes. To enforce effective and robust regularization terms for geophysical inversions on the unstructured meshes, we propose algorithms for constructing the smoothness and structural similarity operators that take advantage of the inherent merits of the unstructured meshes. Following a detailed introduction of the general inversion formula that we adopted, the smoothness and reference model constraints on triangular and tetrahedral meshes are proposed based on the neighbouring relationships between different model cells within the meshes. Particularly, a quasi-cross-gradient formulation is derived for triangular meshes suitable for the joint inversion of different kinds of geophysical data. Compared to existing algorithms, the new smoothness operator presents an equal or better performance for constraining the model roughness. In addition, the operator exploits the preferred elongation directions of the underground structures by performing varied constraints in different directions. Furthermore, the other new operator could effectively measure structural information of the inverted model even if the algorithms have incorporated sophisticated constraints from other geophysical or geological data. Demonstrated with the applications on synthetic examples, the new algorithms provide advanced regularization techniques for conducting geophysical inversions using unstructured meshes.
Creating a post-pandemic sustainable environment in the context of technical and reputational business transformation
Authors: Ibrahim Iman , Tkachenko Daria , Gura Dmitry , Sakulyeva Tatyana 
Published: April 2022

Abstract
The purpose of this article is to propose a new design for a sustainable built environment using a specific business system as an example that transforms and implements modular systems and ultraviolet (UV) lighting to prevent the spread of infectious agents after COVID-19, which directly affects the ability of some types of businesses to function. The paper explores the possibility of purchasing, introducing and using UV radiation for disinfection of premises and the destruction of potentially dangerous viruses and bacteria. The proposed model allows self-isolating persons to adapt to the changing reality and remain productive consumers of goods and services within the business system under study. The modular system, combined with germicidal UV lamps, due to their ability to inactivate viruses, effectively creates a safe hygienic environment, which affects the attractiveness of the territory for visitors and increases the number of ‘contacts’ of the consumer with the company and brand.
Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza
Authors: Okuda Moe , Sakai-Tagawa Yuko , Koga Michiko , Koibuchi Tomohiko , Kikuchi Tadashi , Adachi Eisuke , Ahyoung Lim Lay , Yamamoto Shinya , Yotsuyanagi Hiroshi , Negishi Kyota , Jubishi Daisuke , Yamayoshi Seiya , Kawaoka Yoshihiro 
Published: April 2022

Abstract
On influenza virus infection or vaccination, immune responses occur, including the production of antibodies with various functions that contribute to protection from seasonal influenza virus infection. In the current study, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus. For antibody titers before influenza virus exposure, we found that the nAb titers and enzyme-linked immunosorbent assay titers against hemagglutinin and neuraminidase (NA) proteins in the subclinically infected individuals were significantly higher than those in the patients, whereas the NA inhibition titers and antibody-dependent cellular cytotoxicity activities did not significantly differ between subclinically infected individuals and infected patients. These results suggest that nAb and enzyme-linked immunosorbent assay titers against hemagglutinin and NA serve as correlates of symptomatic influenza infection.
The Obligation to Release and Repatriate Prisoners of Wars: Revisiting the Arbitral Award of Eritrea–Ethiopia Claims Commission
Authors: Tiruneh Wubeshet 
Published: April 2022

Abstract
The Eritrea–Ethiopia Claims Commission hugely contributed to the development of IHL jurisprudence by interpreting, clarifying and applying IHL rules. However, the Commission’s decision regarding the suspension and delay of repatriation of Eritrean POWs by Ethiopia, which was handed down nearly two decades ago, still draws much criticism. On the one hand, the date marking cessation of hostilities, which according to Article 118 of the Geneva Convention Relative to the Treatment of Prisoners of War (GC III) triggers the obligation of Ethiopia to repatriate Eritrean POWs, had not been properly determined. On the other hand, the decision suggested that the obligation of states to repatriate POWs is dependent on the behavior of the other party or subjected to reciprocity. According to the Commission, the repatriation of POWs can be delayed after cessation of hostilities unless the detaining powers get an assurance that their troops would similarly be released and repatriated. However, as I will argue in this article, the suspension and delaying of the repatriation of POWs on the ground of reciprocity runs counter to the unilateral and unconditional nature of the obligation to repatriate POWs under Article 118 of GC III. Nor can it be justified as a legitimate reprisal under IHL and countermeasure under the general rules of state responsibility.
Combined abnormalities of femoral version and acetabular version and McKibbin Index in FAI patients evaluated for hip preservation surgery
Authors: Lerch Till D , Antioco Tiziano , Meier Malin K , Boschung Adam , Hanke Markus S , Tannast Moritz , Siebenrock Klaus A , Schmaranzer Florian , Steppacher Simon D 
Published: April 2022

ABSTRACT
Frequencies of combined abnormalities of femoral version (FV) and acetabular version (AV) and of abnormalities of the McKibbin index are unknown. To investigate the prevalence of combined abnormalities of FV and AV and of abnormalities of the McKibbin index in symptomatic patients with femoroacetabular impingement (FAI), a retrospective, Institutional Review Board (IRB)-approved study of 333 symptomatic patients (384 hips) that were presented with hip pain and FAI was performed. The computed tomography/magnetic resonance imaging based measurement of central AV, cranial AV and FV was compared among five subgroups with distinguished FAI subgroups and patients that underwent a hip preservation surgery. The allocation to each subgroup was based on AP radiographs. Normal AV and FV were 10–25°. The McKibbin index is the sum of central AV and FV. Of patients that underwent a hip preservation surgery, 73% had a normal McKibbin index (20–50°) but 27% had an abnormal McKibbin index. Of all patients, 72% had a normal McKibbin index, but 28% had abnormal McKibbin index. The prevalence of combined abnormalities of FV and AV varied among subgroups: a higher prevalence of decreased central AV combined with decreased FV of patients with acetabular-retroversion group (12%) and overcoverage (11%) was found compared with mixed-type FAI (5%). Normal AV combined with normal FV was present in 41% of patients with cam-type FAI and in 34% of patients with overcoverage. Patients that underwent a hip preservation surgery had normal mean FV (17 ± 11°), central AV (19 ± 7°), cranial AV (16 ± 10°) and McKibbin index (36 ± 14°). Frequency of combined abnormalities of AV and FV differs between subgroups of FAI patients. Aggravated and compensated McKibbin index was prevalent in FAI patients. This has implications for open hip preservation surgery (surgical hip dislocation or femoral derotation osteotomy) or hip arthroscopy or non-operative treatment.
Atypical presentation of an obstructed obturator hernia in a 99-year-old female: a case report
Authors: Anyaugo Ngozi , Nwogwugwu Obisike , Rossi Chiara , Toney Zara 
Published: April 2022

Abstract
An obturator hernia is the protrusion of an organ/tissue through the obturator canal. Fondly called ‘little old lady’s hernia’, as they typically affect elderly thin female patients [7]. They are rare and difficult to clinically diagnose [2]. Diagnosis is often delayed and presentation could vary from symptoms of bowel obstruction, and pain in the groin or medial thigh [6] to atypical presentations like in our case. We report a case of a 99-year-old female with a 3-day history of low back pain, nausea and constipation. Computerized tomography scan revealed small bowel obstruction with transition point in left obturator hernia. The obstruction was successfully relieved via surgery without the need for bowel resection. This case highlights the importance of a high index of suspicion when faced with vague symptoms. Obturator hernias carry a reasonable degree of morbidity and mortality without intervention but have good outcomes if promptly managed.