bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensions of performance and related key performance indicators addressed in healthcare organisations: A literature review
Authors: Gartner Jean‐Baptiste , Lemaire Célia 
Published: March 2022

AbstractIntroductionPerformance measurement systems have become essential managerial tools for healthcare organisations in the last few decades. They allow hospital managers to pilot their institution and assess the development of the organisation in helping managers in decision‐making and viewing the different impacts of these decisions. However, there is a need to investigate further the dimensions of performance those performance measurement systems address.MethodsA literature review was primarily conduced about performance measures in healthcare organisations. A comparative study was secondly made to identify the different performance dimensions that are present in the literature during the last decade. Forty‐nine studies were considered and sixteen proposal frameworks were used to make the comparative analyses.ResultsWe classified dimensions depending on the frequency of mobilisation of their components in four categories: the stars, the first runners‐up, the opportunists and the forgotten ones. For each of the dimensions presented in this classification, the main types of KPIs proposed in the theoretical frameworks are presented. A discussion on relevance and possible blind spots is then conducted.ConclusionAlthough they were a lot of proposal frameworks of KPI proposed in the last decades to assess healthcare organisations, some dimensions remain underrepresented. There is still a need to develop structure KPI and describe their links. To go further, the development of dashboards asks the question of the definition of KPI, the description of their interconnections and their temporality of driving, because static performance reporting systems are not able to completely satisfy healthcare manager's decision support needs.
Forest cover lessens the impact of drought on streamflow in Puerto Rico
Authors: Hall Jazlynn , Scholl Martha , Gorokhovich Yuri , Uriarte María 
Published: March 2022

AbstractTropical regions are experiencing high rates of forest cover loss coupled with changes in the volume and timing of rainfall. These shifts can compromise streamflow and water provision, highlighting the need to identify how forest cover influences streamflow generation under variable rainfall conditions. Although rainfall is the key driver of streamflow regimes, the role of forests is less clear, particularly in tropical regions where forest loss is an ongoing risk. Forest cover loss alters evapotranspiration, rainfall infiltration and storage, and may increase stream ecosystem vulnerability to rainfall extremes. Puerto Rico, an island with spatially heterogenous forest cover and a marked geographic rainfall gradient, is projected to experience more frequent droughts and flash flooding. Using 15‐min streamflow data collected between 2005 and 2016 from 20 US Geological Survey stream gages and 3‐hourly Multi‐Source Weighted‐Ensemble Precipitation rainfall estimates, we utilized flow‐duration curves and linear mixed regression models to examine the role of forest cover in regulating the timing and volume of streamflow. The mixed model approach helps to account for differences in watershed characteristics. We determined the effects of rainfall and forest cover on low and peak flows in Puerto Rican streams, then evaluated changes in these relationships under dry and wet antecedent rainfall conditions. Watersheds with high forest cover had consistently greater low and peak streamflow than deforested ones under all rainfall conditions, although the effect was more marked during wet antecedent conditions, suggesting that peak flow is largely the result of saturation excess overland flow. During dry antecedent rainfall conditions, highly forested watersheds had higher streamflow than deforested ones, suggesting greater hillslope storage and release may also be at play. Our results demonstrate that forest cover generated a net increase in hillslope infiltration and storage and may lessen drought impacts on streamflow in Puerto Rico. Resilience to prolonged drought may be limited by finite water storage potential in this steep, mountainous setting, highlighting maintenance of forest cover as an important water management strategy to increase infiltration.
Partitioning evapotranspiration of winter wheat based on oxygen isotope approach under different irrigation regimes
Authors: Kale Celik Sema , Madenoglu Sevinc , Turker Ufuk 
Published: March 2022

AbstractEvapotranspiration (ET), which is an elusive component of the hydrological cycle, comprises transpiration from plants (T) and evaporation from soil surface (E). In this regard, it is essential to know how much water is lost by T and E during the irrigation period. The overall aim of this study is to separate the ET components by stable oxygen isotopes of winter wheat at the field scale under different irrigation regimes. For this purpose, the field experiment was conducted under rain‐fed, deficit and full irrigation conditions. Soil–water–plant samples were taken for isotopic (18O/16O) analyses. According to the research results, a significant positive relationship was found between applied irrigation water and the average T/ET ratio with a correlation coefficient of 0.81. The T/ET ratios were, on average, 70, 75 and 84% for rain‐fed, deficit and full irrigation treatments, respectively. During the growing season, 231 and 78 mm of irrigation water were applied for full and deficit irrigation, respectively. This showed that water savings of 66% were achieved, although there was a slight (12%) change in transpiration in deficit irrigation. Also, in the use of the oxygen isotope content results indicated that T was the dominant source of total evapotranspiration.
Software for non‐parametric image registration of 2‐photon imaging data
Authors: Flotho Philipp , Nomura Shinobu , Kuhn Bernd , Strauss Daniel J. 
Published: March 2022

AbstractFunctional 2‐photon microscopy is a key technology for imaging neuronal activity. The recorded image sequences, however, can contain non‐rigid movement artifacts which requires high‐accuracy movement correction. Variational optical flow (OF) estimation is a group of methods for motion analysis with established performance in many computer vision areas. However, it has yet to be adapted to the statistics of 2‐photon neuroimaging data. In this work, we present the motion compensation method Flow‐Registration that outperforms previous alignment tools and allows to align and reconstruct even low signal‐to‐noise ratio 2‐photon imaging data and is able to compensate high‐divergence displacements during local drug injections. The method is based on statistics of such data and integrates previous advances in variational OF estimation. Our method is available as an easy‐to‐use ImageJ/FIJI plugin as well as a MATLAB toolbox with modular, object oriented file IO, native multi‐channel support and compatibility with existing 2‐photon imaging suites.
Covering hypergraphs are Eulerian
Authors: Šajna Mateja , Wagner Andrew 
Published: March 2022

AbstractAn Euler tour in a hypergraph (also called a rank‐2 universal cycle or 1‐overlap cycle in the context of designs) is a closed walk that traverses every edge exactly once. In this paper, we define a covering ‐hypergraph to be a nonempty ‐uniform hypergraph in which every ‐subset of vertices appear together in at least one edge. We then show that every covering ‐hypergraph, for , admits an Euler tour if and only if it has at least two edges.
Distinct diagnostic trajectories in NBAS‐associated acute liver failure highlights the need for timely functional studies
Authors: Akesson Lauren S. , Rius Rocio , Brown Natasha J. , Rosenbaum Jeremy , Donoghue Sarah , Stormon Michael , Chai Charmaine , Bordador Esmeralda , Guo Yiran , Hakonarson Hakon , Compton Alison G. , Thorburn David R. , Amarasekera Sumudu , Marum Justine , Monaco Alisha , Lee Crystle , Chong Belinda , Lunke Sebastian , Stark Zornitza , Christodoulou John 
Published: March 2022

AbstractVariants of uncertain significance (VUS) are commonly found following genomic sequencing, particularly in ethnically diverse populations that are underrepresented in large population databases. Functional characterization of VUS may assist in variant reclassification, however these studies are not readily available and often rely on research funding and good will. We present four individuals from three families at different stages of their diagnostic trajectory with recurrent acute liver failure (RALF) and biallelic NBAS variants, confirmed by either trio analysis or cDNA studies. Functional characterization was undertaken, measuring NBAS and p31 levels by Western blotting, demonstrating reduced NBAS levels in two of three families, and reduced p31 levels in all three families. These results provided functional characterization of the molecular impact of a missense VUS, allowing reclassification of the variant and molecular confirmation of NBAS‐associated RALF. Importantly, p31 was decreased in all individuals, including an individual with two missense variants where NBAS protein levels were preserved. These results highlight the importance of access to timely functional studies after identification of putative variants, and the importance of considering a range of assays to validate variants whose pathogenicity is uncertain. We suggest that funding models for genomic sequencing should consider incorporating capabilities for adjunct RNA, protein, biochemical, and other specialized tests to increase the diagnostic yield which will lead to improved medical care, increased equity, and access to molecular diagnoses for all patients.
A precise self‐built secondary mass database for identifying red dyes and dyeing techniques with UPLC‐MS/MS
Authors: Guo Yujie , Shi Lei , Zhou Xudong , Xia Wei , Zhang Lingfan , Xu Zhizhen , Luo Xiyun , Zhang Wenqing 
Published: March 2022

AbstractDyes on ancient silks have been a worth studying field through human's history, although current reports ignore the connection between natural dyes origin and relevant colour reduction methods, which poses an insurmountable obstacle for restoration of historical silks. In this paper, a series of 12 red hue silks from six natural dyes (sappanwood, Chinese madder, safflower, lac, cochineal, dragon's blood) via three different dyeing techniques were used to establish a self‐built precise tandem mass spectrometry (MS/MS) database. With organic solvent extracting on those manual‐dyed silks, ultraperformance liquid chromatography ‐ electrospray ionization ‐ quadrupole time of flight mass spectrometry (UPLC‐ESI‐QTOF‐MS) was utilized to form preliminary MS database for screening and identifying of the potential dyes compounds without standard references. Furthermore, combining the targeted MS/MS mode and the matching threshold of 70.00, a self‐built secondary MS/MS database was successfully established, which contains 33 compounds, 32 chromatograms and 32 MS/MS fragments. As for real sample application, the self‐built precise MS/MS database had revealed that the dyes on two historical silks (Shanghai Museum, China) belong to Chinese madder just with different mordant dyeing ordinal. Additionally, by experimental restoration, visually indistinguishable silks (ΔEab* < 1.5 NBS) were successfully restored. This explorative methodology can further inspire the traceability of biological dyestuffs, which lays instructive foundation on protection and restoration of artefacts, connecting the archaeological science and human art.
When cyclin‐dependent kinases meet viral infections, including SARS‐CoV‐2
Authors: Yan Yan , Tang Yan‐dong , Zheng Chunfu 
Published: March 2022

AbstractCyclin‐dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional regulation. Recent studies have demonstrated the critical roles of CDKs in various viral infections. However, the molecular processes underpinning CDKs' roles in viral infection and host antiviral defense are unknown. This minireview briefly overviews CDKs' functions and highlights the most recent discoveries of CDKs' emerging roles during viral infections, thereby providing a scientific and theoretical foundation for antiviral regulation and shedding light on developing novel drug targets and therapeutic strategies against viral infection.
Two years after pulmonary vein isolation guided by ablation index—a multicenter study
Authors: Sousa Pedro A. , Puga Luís , Adão Luís , Primo João , Khoueiry Ziad , Lebreiro Ana , Fonseca Paulo , Lagrange Philippe , Elvas Luís , Gonçalves Lino 
Published: March 2022

AbstractBackgroundThe use of the Ablation Index (AI) software for paroxysmal atrial fibrillation (AF) has been associated with higher acute effectiveness and higher 1‐year arrhythmia freedom. There is, however, a lack of data concerning longer follow‐up. We aim to evaluate the 2‐year outcomes after a standardized AI‐guided pulmonary vein isolation (PVI).MethodsProspective, multicenter study of consecutive patients referred for paroxysmal AF ablation from January 2018 to July 2019. PVI was guided by a tailored AI value (≥500 for anterior segment, ≥450 for the roof segments and inferior segments, and 400 for the posterior wall) and an ILD ≤6 mm. The primary endpoints were acute and long‐term effectiveness.ResultsThe study included 218 (842 PV) patients (61% males, median age of 60 [IQR 49–68] years) with paroxysmal AF. First‐pass isolation was obtained in 93% of the patients, with an acute reconnection occurring in 10.6% of the patients (3.2% of the PV) following adenosine trial. After a median follow‐up of 26 (IQR 20–30) months, freedom from any documented atrial arrhythmia was 83.4%, off‐AAD. The rate of adverse events was 1.4%. Although procedural parameters differ across centers (p < 0.001), the acute (p = 0.56) and long‐term effectiveness (p = 0.83) were consistent between centers.ConclusionsPatients with paroxysmal AF submitted to an AI‐guided PVI workflow presented high arrhythmia freedom at 2‐years of follow‐up.
Evaluation of the accuracy of soft tissue thickness measurements with three different methodologies: An in vitro study
Authors: Ferry Katherine , AlQallaf Hawra , Blanchard Steven , Dutra Vinicius , Lin Wei‐Shao , Hamada Yusuke 
Published: March 2022

AbstractBackgroundSoft tissue thickness (STT) influences esthetics, peri‐implant, and periodontal health. Non‐invasive methods of STT evaluation include cone‐beam computed tomography (CBCT) with Digital Imaging and Communications in Medicine (DICOM) files and registration of DICOM files with an intraoral scan or Standard Tessellation Language (STL) files. This study compares three methodologies: bone sounding, DICOM data alone, and DICOM and STL registration to absolute histomorphologic values.MethodsFive human maxillas, including teeth numbers 6 to 11, provided 90 sites for analysis. For standardization, reference grooves were placed at the cervical margin and the long axis of each tooth. Direct measurements with a no. 25 K‐file were completed at the facial soft tissues at 3.00, 5.00, and 7.00 mm from the apical marginal reference. Indirect measures were performed with implant planning software. Histological measurements were rendered with imaging software. One‐way analysis of variance (ANOVA) was used to compare the three techniques for the differences from histologic measurements (α = 0.05).ResultsSeventy‐two sites were included for final analysis. The overall mean histological STT (mSTT) was 0.73 ± 0.31 mm. Bone sounding overestimated mSTT, 0.22 ± 0.20 mm (P < 0.001); whereas, DICOM alone underestimated mSTT, −0.23 ± 0.19 mm (P < 0.001). DICOM and STL registration had non‐statistically significant differences, −0.04 ± 0.21 mm (P = 0.429). Intraclass correlation coefficient (ICC) of DICOM and STL registration achieved the highest agreement with histology (ICC: 0.74).ConclusionsDICOM and STL file registration had the highest agreement with histological STT supporting the use of DICOM and STL registration for the evaluation of STT.
Alveolar ridge preservation reduces the need for ancillary bone augmentation in the context of implant therapy
Authors: Couso‐Queiruga Emilio , Mansouri Cyrus J. , Alade Azeez A. , Allareddy Trishul V. , Galindo‐Moreno Pablo , Avila‐Ortiz Gustavo 
Published: March 2022

AbstractBackgroundThere is limited information on the need for bone augmentation in the context of delayed implant placement whether alveolar ridge preservation (ARP) is previously performed or not. The primary aim of this retrospective cohort study was to evaluate the efficacy of ARP therapy after tooth extraction compared with unassisted socket healing (USH) in reducing the need for ancillary bone augmentation before or at the time of implant placement.MethodsAdult subjects that underwent non‐molar single tooth extraction with or without simultaneous ARP therapy were included in this study. Cone beam computed tomography scans obtained before tooth extraction and after a variable healing period were used to record the baseline facial bone thickness and to virtually plan implant placement according to a standard method. A logistic regression model was used to evaluate the effect of facial alveolar bone thickness upon tooth extraction and baseline therapy (USH or ARP) on the need for additional bone augmentation, adjusting for several covariates (i.e., age, sex, baseline KMW, and tooth type).ResultsOne hundred and forty subjects that were equally distributed between both baseline therapy groups constituted the study population. Implant placement was deemed virtually feasible in all study sites. Simultaneous bone augmentation was considered necessary in 60% and 11.4% of the sites in the USH and ARP group, respectively. Most of these sites (64.2% in the USH group and 87.5% in the ARP group) exhibited a thin facial bone phenotype (<1 mm) at baseline. Logistic regression revealed that the odds of not needing ancillary bone augmentation were 17.8 times higher in sites that received ARP therapy. Furthermore, the need for additional bone augmentation was reduced 7.7 times for every 1 mm increase in facial bone thickness, regardless of baseline therapy.ConclusionsBased on a digital analysis, ARP therapy, compared with USH, and thick facial alveolar bone largely reduce the need for ancillary bone augmentation at the time of implant placement in non‐molar sites.
Immunosuppressant prescribing patterns in elderly kidney transplant recipients using registry data from Australia and New Zealand
Authors: Cossart Amelia R. , Cottrell W. Neil , Mcstea Megan , Isbel Nicole M. , Campbell Scott B. , Staatz Christine E. 
Published: March 2022

AbstractBackgroundThe elderly is the fastest growing kidney transplant recipient group; however, they are more likely to die from immunosuppressant side effects than graft failure.AimThe aim of this study was to explore immunosuppressant prescribing practices in elderly kidney transplant recipients.MethodWe conducted a retrospective audit of registry data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry between 2000 and 2015, to determine the actual prescribing trends of immunosuppressant drugs in elderly recipients (≥65 years). Drug choice and doses, prescribed initially and at 1‐year, were examined, with a survival analysis conducted to determine if drug regimen influenced graft survival.ResultsSix hundred and one elderly recipients were included in the analysis. Elderly patients were less likely to be prescribed tacrolimus at 1 year than younger patients, and median doses (149.3 vs 155.6 micrograms/kg; p < 0.05) were significantly lower in elderly patients across the timeframe (initially and at 1‐year post‐transplant). We also observed that elderly recipients prescribed dual immunosuppressant therapy (compared to triple therapy) had an increased risk of graft loss (p < 0.05).ConclusionBy examining Registry data across a 15‐year span, we observed differences in both immunosuppressant usage and drug dosing trends in elderly recipients. The implications of these findings may suggest that guidelines need adjustment to reflect this.
First‐principle investigation of defect‐associated LVM and structural parameter dependency in response to the ground state on‐site Hubbard correction of w‐ZnO
Authors: Ahmed Eliyash , Senthilkumar Kasilingam 
Published: March 2022

AbstractWe report a combined experimental (at 81 K, room temperature) and theoretical Raman study of plasma synthesized ZnO nanoparticles. The linear response method calculates the on‐site Coulomb interaction (Hubbard correction) energies Ud = 12.65 eV and Up = 7.65 eV. The structural changes and hybridization mechanism of the d‐p orbital of Zn and O have shown a significant role in bandgap discrepancies. Density of state (DOS) calculations under the influence of Hubbard correction explains the d‐band energy shift mechanism. Over underestimation of bandgap energies phenomena turns out to be highly sensitive to the choice of pseudopotential, and a series of calculations have been reported to converse to greater accuracy. The theoretical calculation was made possible using generalized gradient approximation (GGA)‐based basis set Perdew, Burke, and Ernzerh (PBE); B3LYP; and local density approximation (LDA). Estimates improve accuracy by including the Hubbard correction energy to the ground state energy calculation using the LDA. We have provided approximations methods suitable for the defect complex study based on our systematic analysis among PBE, B3LYP, and LDA. For the correlated system, the choice of pseudopotential is primarily essential; therefore, the present article also discusses the application of Hubbard correction energy only to a specific orbital and consequences. Experimentally observed fundamental and multiphonon decay processes are explained. The defect trapped hydrogen and defect complex configuration state
, m = 1, …, 4, local vibrational mode is observed. Systematic molecular design and simulation support the experimentally reported results. The VZn, in association with a single 1s electron of hydrogen, compromises state followed by silent, and second‐order features are presented.