bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eco-innovation in the upstream supply chain: re-thinking the involvement of purchasing managers
Authors: Viale Laurence , Vacher Stéphano , Bessouat Jeanne 
Published: January 2022

Purpose
In a context of ecological transition, this study aims to explore and understand what fosters the participation of purchasing departments and identify the drivers and difficulties encountered during the development of eco-innovation within firms.

Design/methodology/approach
The authors adopt a qualitative methodology that provides tools to study complex phenomena. In-depth interviews with highly knowledgeable respondents from multi-sectoral organisations enable us to explore the eco-innovation process within firms.

Findings
From the perspectives of resource-based theory and stakeholder theory, the study contributes to the literature by investigating firms’ internal resources and exploring further dimensions based on sustainable supply chain management and purchasing. Internal stakeholders (e.g. purchasing agents) and external stakeholders (e.g. suppliers) were identified with regard to the business eco-innovation activities of focal companies in relation to upstream stakeholders. The authors examine this complex phenomenon by raising certain intra- and inter-organisational factors, as well as more individual aspects, such as the sensitivity of the purchasing manager to ecological transition. Purchasing agents are involved in increasing the propensity of organisations to eco-innovate and, as internal stakeholders, appear to be influential in eco-innovation.

Research limitations/implications
Given the nascent state of eco-innovation practice and accessibility to primary data about ongoing efforts, this research could not consider all possible drivers.

Practical implications
This study presents an opportunity for purchasing managers to understand challenges more comprehensively to add value within the eco-innovation process. The results highlight recommendations for how best to undertake eco-innovation in upstream supply chains.

Originality/value
The study provides new insights into the constituent resources needed for purchasing participation during eco-innovation to achieve sustainable competitive advantage. This paper is an initial attempt at research in the area.
‘Someone’ versus ‘something’: A reflection on transhumanist values in light of education
Authors: Bokedal Tomas , Reindal Solveig Magnus , Rise Svein , Wivestad Stein M 
Published: January 2022

Abstract
Innovations in genetics, nanotechnology and artificial intelligence involve the possibility of enhancement of human attributes and capacities—offering humans innumerable opportunities for diverse, unprecedented experiences and developments both physically and cognitively. These new innovations, frequently associated with theoretical frameworks such as transhumanism, not only raise new ethical–pedagogical questions but also challenge the very meaning of education. Core educational concepts pertaining to the human being, personhood, and the educational self now need to be re-examined or rediscovered in confrontation with transhumanist values. In regard to this task, we investigate Bostrom's teleological approach towards transhumanist values, questioning his understanding of the human person and the inherent implications of a sensible agenda for education, situated within the broad humanist tradition. As an alternative to an educational prospect based on, or endorsing, transhumanist values, we adopt Spaemann's personalist program, implementing his distinction between ‘being someone’ versus ‘being something’. Defending an understanding of the person as someone, and not as a thing that shall be cultivated, we employ Spaemann's distinction between anthropocentrism versus anthropomorphism, recognising the importance of contextualising the human being in a broader existential, embodied framework, while acknowledging the critique of the anthropocene. Along these lines, we elaborate on an understanding of education and the educated person that, in our view, safeguards core human values. In the discussion, we draw on insights from Spaemann, Arendt, Kierkegaard and Gadamer.
Moral sensitivity: The central question of moral education
Authors: Marples Roger 
Published: January 2022

AbstractThere is more to the moral life than mere adherence to a set of moral rules or principles to which the moral agent has autonomously subscribed. Something more fundamental is required for moral personhood, requiring explication in terms of ‘sensitive perception’ in relation to the particularities pertaining to any given set of circumstances meriting a moral response. The article addresses the importance of accuracy of conceptualisation, the need for attentiveness and sensitivity in the identification of moral salience, and concludes with the role of affect in this enterprise.
Time‐varying effect of monetary policy on capital flows in Korea
Authors: Hur Joonyoung , Kim Kyunghun 
Published: January 2022

AbstractThis paper examines the effect of domestic monetary policy on capital flows after controlling for the effect of conventional push factors (global factors). We conduct a time‐varying coefficient vector autoregressive (TVC‐VAR) model analysis using monthly data (January 2010–July 2019) from Korea. Our empirical results show that an expansionary monetary policy shock has a short‐run (1‐ and 3‐month) negative impact on gross inflows to the equity market, which is the main driver of gross capital inflows to Korea. This negative effect increases throughout the sample period. Monetary policy easing is also associated with a decrease in outflows of equity, representing a reversal of Korean residents’ foreign equity investment as the domestic policy rate decreases. This effect dampens the negative impact on gross capital inflows, which leads to mild responses of net capital inflows in the short run. We also find a clear relationship between the level of the policy rate and its impact on gross capital inflows. The lower the policy rate, the greater the negative impact of the expansionary monetary policy shock on gross capital inflows. This time‐varying effect reflects difficulties that many emerging market economies, including Korea, face in setting monetary policy when policy rates are low.
Effects of a nursing home telehealth program on spending and utilization for Medicare residents
Authors: Li Suhui ( Evelyn) , Hossain Mynti , Gilman Boyd , Forrow Lauren V. , Lee Katie M. , Brown Randall 
Published: January 2022

AbstractObjectiveTo assess the effects of eLongTermCare (eLTC), a telehealth program implemented by an integrated health system in 45 nursing homes across the Midwest, on the use of acute hospital services and total expenditures for Medicare residents.Data SourcesMinimum Data Set, Medicare fee‐for‐service claims, and enrollment data from 2013 to 2018.Study DesignWe used a longitudinal difference‐in‐differences design to estimate the changes in outcomes for treatment beneficiaries before and after participating in the eLTC program, relative to changes for the matched comparison beneficiaries over the same period. We measured outcomes over a 24‐month follow‐up period, including total Medicare spending, emergency department (ED) visits, hospitalizations, and the likelihood of readmission.Data Collection/Extraction MethodsUsing administrative data, we identified treatment beneficiaries who stayed at participating nursing facilities during the program period and matched comparison beneficiaries with similar baseline characteristics from non‐participating facilities in the same geographic locations.Principal FindingsFor long‐term care residents, the eLTC program led to an estimated reduction of 73 ED visits per 1000 beneficiaries (p < 0.01, 8.6% effect) over the two‐year follow‐up period. The estimated effects for this group were concentrated among beneficiaries who entered the nursing home after program startup, with sizable reductions in hospitalizations, ED visits, and spending. For skilled care residents, the program was associated with an estimated reduction of 85 ED visits per 1000 beneficiaries (p = 0.03, 9.7% effect), but had no discernible effect on their hospitalizations or total Medicare spending.ConclusionsTelehealth can be a valuable tool for nursing homes to enhance care coordination and provide timely access to care, leading to lower spending for nursing home residents. Future research needs to explore payment methods that encourage telehealth expansion in nursing homes.
Controversial Practices: Tracing the Proceduralization of the IPCC in Time and Space
Authors: De Pryck Kari 
Published: January 2022

AbstractThis paper starts from the premise that international practices are neither stable nor universal but are in fact the product of time and space. It analyzes the processes of formalization and change in international practices using the case of the Intergovernmental Panel on Climate Change (IPCC), an intergovernmental institution producing regular assessment of the state of the knowledge on climate change. The IPCC is particularly interesting because of the numerous external and internal controversies that it has faced since its establishment in 1988 and the institutional and organizational changes that they triggered. The paper highlights the potential of controversies as methodological occasions to observe the situatedness of international practices and trace change over time. Controversies represent moments of contention in which the normalizing and universalistic effect of routines and procedures is momentarily suspended, thus facilitating the investigation of the particular space and time in which practices evolve.
'Your Own Space and Time': Spatiality and Temporality in the Study of the International Organisations of the Middle East
Authors: Worrall James 
Published: January 2022

AbstractThe regional international organisations of the Middle East clearly work to different traditions than Western International Organisations (IOs) and are comprised of states which are known for their secrecy and hostility to critique. This is methodological challenge enough without taking into account the influences of temporal and spatial practices upon the functioning of these organisations. Using anthropological approaches to time and space an argument is advanced that putting temporal and spatial considerations at the heart of the study of these bodies impacts upon our conceptual, theoretical and methodological outlooks – generating richer, more nuanced insights. Thus, not only do time and space form an important research agenda in their own right but they also better inform existing theoretical understandings of IOs, particularly the historical and sociological institutionalist traditions. Drawing from direct experience with some of the key difficulties researchers face when engaging with these organisations, the article demonstrates the need for a reflexive and adaptive methodological engagement which can engage with the impacts of place and perceptions of time, examining these bodies less in comparison with the expectations scholars carry for IOs such as the UN and EU and more on their own terms, in their own situational and temporal contexts.
Risk factors for pneumonitis in patients with non‐small cell lung cancer treated with immune checkpoint inhibitors plus chemotherapy: A retrospective analysis
Authors: Yamaguchi Teppei , Shimizu Junichi , Oya Yuko , Watanabe Naohiro , Hasegawa Takaaki , Horio Yoshitsugu , Inaba Yoshitaka , Fujiwara Yutaka 
Published: January 2022

AbstractBackgroundImmune checkpoint inhibitor (ICI) therapy plus chemotherapy has become a standard of care for patients with advanced non‐small cell lung cancer (NSCLC). Pre‐existing interstitial lung disease (ILD) is a risk factor for drug‐induced pneumonitis caused by chemotherapy or ICI monotherapy. However, clinical data in patients with pre‐existing ILD who received ICI therapy plus chemotherapy are limited. This study aimed to identify the risk factors for drug‐induced pneumonitis in patients with NSCLC treated with ICIs plus chemotherapy.MethodsWe retrospectively reviewed the medical records of 160 consecutive patients who were diagnosed with NSCLC and treated with ICIs plus chemotherapy at Aichi Cancer Center Hospital between December 2018 and November 2020. Patients with a prior history of ICI treatment or thoracic radiotherapy were excluded from the analysis.ResultsAmong 125 patients, pre‐existing ILD was observed in 20 patients (16.0%). Drug‐induced pneumonitis developed in 17 patients (13.6%), with a median time to onset of 19.3 weeks (range, 1.6–108.9 weeks). In multivariate logistic analysis, pre‐existing ILD (odds ratio = 19.07, p = 0.0001) and PEM exposure (odds ratio = 5.67, p = 0.022) were identified as risk factors for the development of drug‐induced pneumonitis.ConclusionsPre‐existing ILD and pemetrexed exposure are risk factors for drug‐induced pneumonitis in patients with NSCLC.
Exploring noise, degeneracy and determinism in biological networks with the einet package
Authors: Klein Brennan , Swain Anshuman , Byrum Travis , Scarpino Samuel V. , Fagan William F. 
Published: January 2022

Abstract

Understanding noise in networks and finding the right scale to represent a system are important problems in network biology. Most research focuses on the raw, micro‐scale network from data/simulations and seldom explores the scale dependence of properties.

Here, we introduce the einet package, which looks at the most informative scale in a biological network using recent concepts from information theory and network science.

einet uses two metrics: Effective information, which measures the interplay between degeneracy and determinism in a network’s edges, and causal emergence, which finds the scale of the network with the highest effective information.

einet is available in R and Python and provides tools to explore noise and scale dependency in networks as well as compare information flow and noise across networks.
Repeated blast mild traumatic brain injury and oxycodone self‐administration produce interactive effects on neuroimaging outcomes
Authors: Muelbl Matthew J. , Glaeser Breanna L. , Shah Alok S. , Chiariello Rachel A. , Nawarawong Natalie N. , Stemper Brian D. , Budde Matthew D. , Olsen Christopher M. 
Published: January 2022

AbstractTraumatic brain injury (TBI) and drug addiction are common comorbidities, but it is unknown if the neurological sequelae of TBI contribute to this relationship. We have previously reported elevated oxycodone seeking after drug self‐administration in rats that received repeated blast TBI (rbTBI). TBI and exposure to drugs of abuse can each change structural and functional neuroimaging outcomes, but it is unknown if there are interactive effects of injury and drug exposure. To determine the effects of TBI and oxycodone exposure, we subjected rats to rbTBI and oxycodone self‐administration and measured drug seeking and several neuroimaging measures. We found interactive effects of rbTBI and oxycodone on fractional anisotropy (FA) in the nucleus accumbens (NAc) and that FA in the medial prefrontal cortex (mPFC) was correlated with drug seeking. We also found an interactive effect of injury and drug on widespread functional connectivity and regional homogeneity of the blood oxygen level dependent (BOLD) response, and that intra‐hemispheric functional connectivity in the infralimbic medial prefrontal cortex positively correlated with drug seeking. In conclusion, rbTBI and oxycodone self‐administration had interactive effects on structural and functional magnetic resonance imaging (MRI) measures, and correlational effects were found between some of these measures and drug seeking. These data support the hypothesis that TBI and opioid exposure produce neuroadaptations that contribute to addiction liability.
Communication and collaboration skills training in Radiation Oncology in Australia and New Zealand: A qualitative study
Authors: Levy David C. , Naehrig Diana , Sullivan Lisa , Chin Yaw S. 
Published: January 2022

AbstractPurposeEffective communication and collaboration with patients, carers and between healthcare professionals improves patient management. This study aimed to explore essential communication and collaboration skills training (CCST) for a radiation oncologist (RO) to inform competencies, learning outcomes and enhance curriculum training methods.Materials and MethodsEight focus group discussions with 10 fellows and 14 trainees of the Faculty of Radiation Oncology, Royal Australian and New Zealand College of Radiologists (FRO RANZCR) were conducted face to face between October 2018 and March 2019. Participants included doctors from culturally and linguistically diverse backgrounds, working in public and private, metropolitan, and rural sectors. Data were recorded, transcribed verbatim, managed in Excel, and coded using a qualitative content analysis framework. The study was approved by South Eastern Sydney Local Health District HREC (18/186). Participants provided informed written consent.ResultsAfter achieving thematic saturation, four predominant themes emerged. These were as follows: (1) Enablers and barriers to effective communication and collaboration; (2) written communication; (3) communicating bad news; and (4) multidisciplinary team meeting collaboration. Managing uncertainty and workplace culture emerged as interconnected sub‐themes.ConclusionsThere is a current lack of CCST in radiation oncology in Australia and New Zealand. The most common theme that emerged to improve CCST focused on increasing the exposure to a variety of communication and collaboration clinical scenarios, which are observed and upon which immediate structured feedback is given. Consultants and trainees offered tangible suggestions on how to improve the curriculum. These findings underscore the importance of using a combination of structured teaching methods and work‐based assessments. CCST templates are recommended.
State Support for Rebels and Interstate Bargaining
Authors: Qiu Xiaoyan 
Published: January 2022

AbstractSince the end of World War II, leaders have frequently supported rebel groups in other countries as a coercive strategy in international disputes. However, the strategic rationale by which rebel groups gain international support is non‐obvious. Many recipient groups are too weak to viably win and are hostile to the sponsoring state's goals. Using a formal model, I explain that the fundamental objective of transnational rebel support is to gain bargaining leverage against a rival state by depleting its resources to counter internal and external challenges. This subversive effect provides a sufficient incentive for sponsoring the rebels even when favourable conditions suggested by previous studies are absent. Sponsoring rebels is attractive even if conventional warfare is not comparatively costly and even if rebel and sponsor preferences diverge. Moreover, given the goal of destabilizing rival regimes, potential sponsors prefer to support weaker rebel groups and provide more support to them.
Reflections on using mobile GPS with young informal vendors in urban Tanzania
Authors: Salvidge Nathan 
Published: January 2022

AbstractThis paper will explore how mobile‐based GPS methods can advance insights into young itinerant vendors' informal livelihood mobilities. It examines the practicalities of using a GPS‐based method in a Majority World context whilst also discussing the merits of combining this approach with mobile methods. The ethical issues of using GPS technology ‘on the move’, and the impact that my presence had whilst I accompanied participants, is also discussed.
Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug‐resistant Gram‐negatives
Authors: Escobar‐Salom María , Torrens Gabriel , Jordana‐Lluch Elena , Oliver Antonio , Juan Carlos 
Published: January 2022

ABSTRACTMammalian innate immunity employs several humoral ‘weapons’ that target the bacterial envelope. The threats posed by the multidrug‐resistant ‘ESKAPE’ Gram‐negative pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are forcing researchers to explore new therapeutic options, including the use of these immune elements. Here we review bacterial envelope‐targeting (peptidoglycan and/or membrane‐targeting) proteins/peptides of the mammalian immune system that are most likely to have therapeutic applications. Firstly we discuss their general features and protective activity against ESKAPE Gram‐negatives in the host. We then gather, integrate, and discuss recent research on experimental therapeutics harnessing their bactericidal power, based on their exogenous administration and also on the discovery of bacterial and/or host targets that improve the performance of this endogenous immunity, as a novel therapeutic concept. We identify weak points and knowledge gaps in current research in this field and suggest areas for future work to obtain successful envelope‐targeting therapeutic options to tackle the challenge of antimicrobial resistance.
HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6‐mediated CD147 polyubiquitination
Authors: Song Qi , Wen Juyi , Li Weiping , Xue Janxin , Zhang Yufei , Liu Hongyan , Han Jixia , Ning Tao , Lu Zejun 
Published: January 2022

AbstractHSP90 inhibition might be a promising strategy to overcome the radioresistance of some cancers. In the current study, we further explored the mechanisms of HSP90 in regulating the radiosensitivity of cervical cancer cells. Bioinformatic analysis was performed based on data from TCGA‐CESC. Cellular and molecular studies were conducted using CaSki and SiHa and the derived radioresistant (RR) subclones. Through a proteomics screen, we identified HSP90 chaperones (both HSP90α and HSP90β) as CD147‐binding partners supporting its stabilization. Targeting HSP90 sensitized CaSki‐RR and SiHa‐RR cancer cells to irradiation partially through CD147 destabilization. Mechanistically, HSP90 interacts with FBXO6 and reduces FBXO6‐mediated proteasomal degradation of CD147. Enforced FBXO6 overexpression also sensitized CaSki‐RR and SiHa‐RR cancer cells to irradiation. These effects were enhanced using 17‐AAG treatment but were weakened by CD147 overexpression. Survival analysis further confirmed the association between high FBXO6 expression and favorable progression‐free survival among patients with cervical cancer. In conclusion, this study showed that HSP90 promotes radioresistance of cervical cancer cells partially via reducing FBXO6 mediated CD147 polyubiquitination. These findings help to explain why HSP90 inhibitor exerts radio‐sensitizing effects in cervical cancer.
HSP90/IKK‐rich small extracellular vesicles activate pro‐angiogenic melanoma‐associated fibroblasts via the NF‐κB/CXCL1 axis
Authors: Tang Hokeung , Zhou Xiaocheng , Zhao Xiaoping , Luo Xinyue , Luo Tingting , Chen Yang , Liang Weilian , Jiang Erhui , Liu Ke , Shao Zhe , Shang Zhengjun 
Published: January 2022

AbstractHypoxia is a main feature of most solid tumors, but how melanoma cells under hypoxic conditions exploit tumor microenvironment (TME) to facilitate tumor progression remains poorly understood. In this study, we found that hypoxic melanoma‐derived small extracellular vesicles (sEVs) could improve the proangiogenic capability of cancer‐associated fibroblasts (CAFs). This improvement was due to the activation of the IKK/IκB/NF‐κB signaling pathway and upregulation of CXCL1 expression and secretion in CAFs. By proteomic analysis, we verified that hypoxia could promote enrichment of chaperone HSP90 and client protein phosphorylated IKKα/β (p‐IKKα/β) in melanoma‐derived sEVs. Delivery of the HSP90/p‐IKKα/β complex by sEVs could activate the IKK/IκB/NF‐κB/CXCL1 axis in CAFs and promote angiogenesis in vitro and in vivo. Taken together, these findings deepen the understanding of hypoxic response in melanoma progression and provide potential targets for melanoma treatment.