bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of COL7A1 as a prognostic biomarker in lung squamous cell carcinoma
Authors: Song Weihao , Li Ling , Zhang Jinyu , Wang Shuang , Leng Zhe , Lu Ran , Li Chenglin , Ma Xiaoran , Wang Tiantian , Jia Xihui 
Published: June 2022

Abstract
The Collagen Type VII Alpha 1 Chain (COL7A1) is associated with a variety of cancers, however, COL7A1 gene expression in human lung squamous cell carcinoma (LUSC) and its prognostic value have not been well studied. In this study, we used bioinformatics database to analyze the relationship between COL7A1 expression and survival in LUSC patients such as Oncomine, GEPIA, UALCAN, and STRING. And we used Kaplan–Meier plotter to analyze the prognosis of high or low expression of COL7A1 in different patients. We found that COL7A1 was significantly overexpressed in patients with LUSC. Additionally, in the survival analysis, COL7A1 expression was significantly associated with worse overall survival (OS), first progression (FP), Post-progression survival (PPS) in LUSC patients. Moreover, COL7A1 is closely associated with known biomarkers and key factors of LUSC. We used functional annotation enrichment analysis to show that genes co-expressed with COL7A1 were enriched in biological process (BP), cellular component (CC), molecular function (MF) and KEGG pathways. Furthermore, Laminin 332 and its association with COL7A1 may lead to the activation of the PI3K signaling pathway, ultimately leading to squamous cell carcinoma (SCC). This has also been mentioned in other people's research. Therefore, our work was designed to demonstrate the potential of COL7A1 as a prognostic biomarker in LUSC.
Outcome of Membranous Pulmonary Valve Atresia with Intact Ventricular Septum Treated by Cardiac Catheterization in a Developing Country
Authors: AL-Ammouri Iyad , Nimer Abdullah , Naser Suzan , Yousef Reda , Hani Mohamed Abu , Fadaleh Mohammad Abu , Karasneh Sahar 
Published: June 2022

Abstract
Background: Pulmonary atresia with intact ventricular septum is a cyanotic heart disease with variable morphological features depending on the degree of right ventricular and tricuspid valve hypoplasia. Currently, the standard management for plate-like, membranous pulmonary atresia includes pulmonary valve perforation using radiofrequency wire and pulmonary valve dilation, with or without ductus arteriosus stenting. Radiofrequency wires are expensive and not available in many developing countries. We report our experience with perforation of the pulmonary valve using coronary wires followed by balloon dilation, with or without ductus arteriosus stenting.Methods: This is a retrospective review of patients with pulmonary atresia and intact ventricular septum who underwent initial percutaneous treatment at our institution between 2012 and 2020. Patients were followed till March 2022. We describe the baseline anatomy, procedure success and complications, and outcome.Results: Fifteen patients were treated during the study period. Pulmonary valve perforation using soft end of a hydrophilic-tip coronary wire was successful in 14 patients (93%). Ductus arteriosus stenting was performed in 10 patients. There was one post-procedure mortality due to neonatal sepsis. By the last follow up at median age of 34 months (21-100), twelve patients had 2-ventricular circulation, One with 1.5-ventricle circulation, and one with univentricular circulation. Conclusions: Perforation of atretic pulmonary valve using soft end of hydrophilic-tip coronary wire for patients with membranous pulmonary atresia and intact ventricular septum is highly successful. Most patients will end up with 2-ventricular circulation.
Theoretical study on the quantum well junction CrI3/CrGeTe3
Authors: Moaied Mohammed , Soliman S. 
Published: June 2022

Abstract
Electronic structure calculations were conducted for the CrI3/CrGeTe3 junction with different separations (z) between the two slabs CrI3 and CrGeTe3, which provide a means to resolve the magneto-volume spin coupling. The calculations demonstrate that high electron mobility, high frequency and strongly electronic structure modification are obtained at specific value for slab separation (z). z=0.36238, which is equivalent to the insulating separation of 13.85 ˚A, is preferable for free to move carriers, while the spin wave maximum is at z=18 ˚A. The moment observed in the DOS of the CrI3 layer supports an increase in the surface field, which in turn explains the effectiveness of the CrI3 layer in tunneling applications. The CrI3 Fermi surface contains small electronic pockets derived from the Cr-3d doubly degenerate state at M. The doubly degenerate effective mass m∗ is approximately constant near the bottom of the nearly free elec-tron band, but the triply m∗ increases somewhat at the inflection point by the Cr-3d magnetic field. Depending on the number of d-electrons, the junctions CoMnI3/CrGeTe3, MoI3/CrGeTe3 and WI3/CrGeTe3 are examined. The comparison between CoMnI3, MoI3 and WI3 and CrI3 ensures that the performance of the CrI3 layer is due to the activity of Cr-3d, which provides a unique opportunity to control the junction prop- erties. The DOS shape of the MoI3 layer demonstrates fairly interesting magnetic properties that are nearly similar to those of the CrI3 layer.
Xerostomia in Dialysis Patients – Oral Care to Reduce Hyposalivation, Dental Biofilms and Gingivitis in Patients with Terminal Renal Insufficiency
Authors: Gaengler Peter 
Published: June 2022

Abstract
Objectives Dialysis patients suffer from xerostomia based on hyposalivation even in stimulated saliva testing. It was, therefore, the aim (i) to evaluate an optimized oral hygiene system with an oral care gel on oral dryness, dental plaque control and number of gingivitis teeth, (ii) to document the efficacy in a randomized controlled trial with dental indices and (iii) to record the individual oral health-related quality of life.MethodsAfter ethical approval (EC-UWH 103/2019), 44 dialysis patients signed informed consent forms and were divided into two groups followed up for four weeks. Subjects in verum group A were taking the daily oral care gel OROFAN® based on biopolymers with mild antibacterial and saliva stimulating action. They were compared to control group B executing routine oral hygiene with conventional dentifrice and toothbrushes. The Oral Health Impact Profile was documented at baseline and at the end of the study.ResultsTwenty-two subjects were allocated to group A and group B. At baseline, there were no significant differences concerning renal insufficiency (years on dialysis, complications), systemic diseases, or dental background (caries experience, periodontal diseases, plaque index, number of gingivitis teeth). All subjects exhibited hyposalivation (< 0.7-1.0 ml/min).Control group B showed no significant differences from baseline to the end of the study in dry mouth parameters, in all dental plaque and inflammation indices, or in the Oral Health Impact Profile. In contrast, verum group A exhibited a highly significant (p<0.001) decrease in xerostomia frequency, number of gingivitis teeth and plaque index. The Oral Health Impact Profile improved considerably (p<0.01).Significance of ResultsTerminally ill patients may gain better oral health and, consequently, improved quality of life by rather simple oral care, including long-lasting, eatable anti-inflammatory oral hygiene gel and dentist’s devotion.
Unmarried Sri Lankan Youth: Sexual Behaviour and Contraceptive Use
Authors: Kumarasinghe Malith , De Silva W Indralal , de Silva Ranjith , Suranga M Suchira 
Published: June 2022

Abstract
Background Youth are at high risk for casual and unprotected sexual activities even before the marriage. The objective of the study is to describe the sexual behavior, contraceptive use among unmarried youth of Sri Lanka and to assess the factors associated with sexual behaviour. Methods Observational descriptive cross-sectional study was conducted in three selected districts in Sri Lanka from 1st of March 2019 to 31st of January 2020 among 1057 never-married youth using a self-administered questionnaire. Both stratified cluster sampling and snow-ball sampling was used to select the eligible never-married youth. Factors associated with the sexual intercourse was assessed using logistic regression. Results Compared to boys (26%), more girls (35%) were engaged in unprotected sexual intercourse. Among sexually active unmarried youth aged less than 20 years, 10% had sexual intercourse with an unknown person. Unmarried Tamil and estate sector youth displayed significantly lower chances of sexual intercourse compared to Sinhala and urban counterparts (OR=0.390, CI=0.213-0.715, p=0.002 and OR=0.807, CI=0.709-0.978, p=0.020 respectively). Youth in rural (69.5%) and urban sector (87.3%) tend to use contraceptives during the intercourse compared to the youth in the Estate sector (51.1%). Conclusions A significant portion of youth expose to sexual risk behavior including unprotected sexual intercourse even before the marriage which can contribute to many social and health consequences. Focus interventions are needed to address the issue.
Propuesta de aplicativo para medir el costo de pérdida de buena voluntad para mejorar la previsión colaborativa respecto al consumo.
Authors: Sánchez Pineda Daniel Enrique , Sánchez Caimán Pedro José , Beltrán Zapata Ana Maria 
Published: June 2022

El presente trabajo propone un aplicativo que permita medir el costo de pérdida de buena voluntad, como un componente que se encuentra involucrado con la pérdida de ventas, de este modo se podrá incrementar la capacidad de diagnóstico en la ejecución de previsiones colaborativas para abordar soluciones respecto al consumo.
Para lograr satisfacer los requerimientos de los clientes, la mayoría de las decisiones relacionadas con el inventario, deben estar basadas en previsiones respecto al consumo. Para esto las empresas consideran los procesos colaborativos como un método de gestión, que permite ampliar el panorama de oportunidades. La dificultad se presenta cuando existen aspectos que en la práctica resultan ser complejos de estimar, esto puede convertirse en un problema derivado por la ausencia de datos, que como consecuencia pueden generar una gestión deficiente de la demanda, con pronósticos errados y costos elevados.
La propuesta que planteada en este artículo se presenta la posibilidad de estimar dicho costo, mediante el empleo del IdC junto con técnicas de pronóstico. Presentando así, información sobre el comportamiento de los consumidores y el impacto que tiene el costo de perdida de buena voluntad dentro de la rentabilidad de un punto de venta.
High Risk of Metabolic Complications Due to High Consumption of
Processed Foods
Authors: Vellapandian Chitra , Singh Ankul 
Published: June 2022

Abstract:
The lack of knowledge among adolescents makes them more sensitive to engage in unhealthy habits which might harm health and nutritional status. A high caloric diet and lack of physical activity are responsible for the generation of reactive oxygen species leading to neurological diseases. The gap in knowledge about Junk food and its complications poses a significant threat to public health policy. Metabolic Syndrome develops due to high fat-induced chronic inflammation and leads to cognition disturbances, stroke, and neurological diseases such as Alzheimer's disease. Adolescent age is the most devastating one where several Lifestyle associated diseases (Sophisticated and cozy lifestyle) occur and is linked with chronic diseases viz., Alzheimer, Non-Alcoholic Steatohepatitis, Type 2 Diabetes Mellitus, Non-Alcoholic Fatty liver disease, Obesity, Hypertension, etc. The unstructured eating behaviors should be prevented at the earliest to overcome the "Fast food Genocide" from eating Processed foods to obesity and nutritional deficiencies leading to neurological complications and destructing the brain cell. As we age, memory begins to decline, and thus by lowering our intake of high calorific foods and salt intake, we could reduce metabolic syndrome-related and age-related issues like blood pressure, T2DM, obesity, etc. Thus, to curb diseases linked with Junk foods, awareness about nutritional values of foods among adolescents and higher tax slabs of junks foods should be made to reduce the purchase of such products.
Tweets Related to Motivation and Physical Activity for Obesity-Related Behavior Change: Descriptive Analysis
Authors: Park Albert 
Published: June 2022

Background
Obesity is one of the greatest modern public health problems, due to the associated health and economic consequences. Decreased physical activity is one of the main societal changes driving the current obesity pandemic.

Objective
Our goals are to fill a gap in the literature and study whether users organically utilize a social media platform, Twitter, for providing motivation. We examine the topics of messages and social network structures on Twitter. We discuss social media’s potential for providing peer support and then draw insights to inform the development of interventions for long-term health-related behavior change.

Methods
We examined motivational messages related to physical activity on Twitter. First, we collected tweets related to physical activity. Second, we analyzed them using (1) a lexicon-based approach to extract and characterize motivation-related tweets, (2) a thematic analysis to examine common themes in retweets, and (3) topic models to understand prevalent factors concerning motivation and physical activity on Twitter. Third, we created 2 social networks to investigate organically arising peer-support network structures for sustaining physical activity and to form a deeper understanding of the feasibility of these networks in a real-world context.

Results
We collected over 1.5 million physical activity–related tweets posted from August 30 to November 6, 2018. A relatively small percentage of the tweets mentioned the term motivation; many of these were made on Mondays or during morning or late morning hours. The analysis of retweets showed that the following three themes were commonly conveyed on the platform: (1) using a number of different types of motivation (self, process, consolation, mental, or quotes), (2) promoting individuals or groups, and (3) sharing or requesting information. Topic models revealed that many of these users were weightlifters or people trying to lose weight. Twitter users also naturally forged relations, even though 98.12% (2824/2878) of these users were in different physical locations.

Conclusions
This study fills a knowledge gap on how individuals organically use social media to encourage and sustain physical activity. Elements related to peer support are found in the organic use of social media. Our findings suggest that geographical location is less important for providing peer support as long as the support provides motivation, despite users having few factors in common (eg, the weather) affecting their physical activity. This presents a unique opportunity to identify successful motivation-providing peer support groups in a large user base. However, further research on the effects in a real-world context, as well as additional design and usability features for improving user engagement, are warranted to develop a successful intervention counteracting the current obesity pandemic. This is especially important for young adults, the main user group for social media, as they develop lasting health-related behaviors.
Predicting Therapeutic Response to Unfractionated Heparin Therapy: Machine Learning Approach
Authors: Abdel-Hafez Ahmad , Scott Ian A , Falconer Nazanin , Canaris Stephen , Bonilla Oscar , Marxen Sven , Van Garderen Aaron , Barras Michael 
Published: June 2022

Background
Unfractionated heparin (UFH) is an anticoagulant drug that is considered a high-risk medication because an excessive dose can cause bleeding, whereas an insufficient dose can lead to a recurrent embolic event. Therapeutic response to the initiation of intravenous UFH is monitored using activated partial thromboplastin time (aPTT) as a measure of blood clotting time. Clinicians iteratively adjust the dose of UFH toward a target, indication-defined therapeutic aPTT range using nomograms, but this process can be imprecise and can take ≥36 hours to achieve the target range. Thus, a more efficient approach is required.

Objective
In this study, we aimed to develop and validate a machine learning (ML) algorithm to predict aPTT within 12 hours after a specified bolus and maintenance dose of UFH.

Methods
This was a retrospective cohort study of 3019 patient episodes of care from January 2017 to August 2020 using data collected from electronic health records of 5 hospitals in Queensland, Australia. Data from 4 hospitals were used to build and test ensemble models using cross-validation, whereas data from the fifth hospital were used for external validation. We built 2 ML models: a regression model to predict the aPTT value after a UFH bolus dose and a multiclass model to predict the aPTT, classified as subtherapeutic (aPTT <70 seconds), therapeutic (aPTT 70-100 seconds), or supratherapeutic (aPTT >100 seconds). Modeling was performed using Driverless AI (H2O), an automated ML tool, and 17 different experiments were iteratively conducted to optimize model accuracy.

Results
In predicting aPTT, the best performing model was an ensemble with 4x LightGBM models with a root mean square error of 31.35 (SD 1.37). In predicting the aPTT class using a repurposed data set, the best performing ensemble model achieved an accuracy of 0.599 (SD 0.0289) and an area under the receiver operating characteristic curve of 0.735. External validation yielded similar results: root mean square error of 30.52 (SD 1.29) for the aPTT prediction model, and accuracy of 0.568 (SD 0.0315) and area under the receiver operating characteristic curve of 0.724 for the aPTT multiclassification model.

Conclusions
To the best of our knowledge, this is the first ML model applied to intravenous UFH dosing that has been developed and externally validated in a multisite adult general medical and surgical inpatient setting. We present the processes of data collection, preparation, and feature engineering for replication.
La fatiga del sistema educativo mexicano
Authors: Ornelas Carlos 
Published: June 2022

En México, cada gobierno, desde el periodo de la educación socialista, ha querido hacer un overhaul en el sistema educativo, pero sin discriminar lo que funciona bien, de lo que debería desecharse. Seguimos con el mismo régimen con más normas y capacidad, pero no funciona porque no excluyó lo inservible. Carga un fardo obeso, está fatigado. El gobierno que comenzará en 2024 tendrá la responsabilidad de iniciar un overhaul si aspira a generar confianza en la ciudadanía, fincar competencias institucionales y ofrecer resultados. Docentes y familias comprometidos con la equidad y la justicia interceden por una educación democrática y equitativa.
Kadar 25(OH)D3 darah pada penderita obesitas
Authors: Hermawan Dessy , Widodo Slamet 
Published: June 2022

Blood level 25(OH)D3 in obese peopleBackground: Currently, obesity is a world problem, even the World Health Organization (WHO) declared obesity to be a global epidemic and contributes 5% of global deaths in 2015. Recently, many studies have reported an association between vitamin D levels and the incidence of obesity, although the exact mechanism raises many questions. Objective: This study is to examine the correlation between levels of 25(OH)D3 and body mass index (BMI).Methods: The design of this research is an analytic survey with a case control approach. The population of this study was all students of the Faculty of Medicine, Malahayati University, Bandar Lampung. The number of samples in this study were 60 samples with details of 30 case samples (obesity) and 30 control samples (no obesity). The sampling technique used was purposive sampling. The data used are primary data from direct measurement results. The data were analyzed using the correlation test.Results: The results showed that only one sample had normal 25(OH)D3 levels, while most (more than 98%) had low and very low levels of 25(OH)D3. The correlation test showed that there was a significant relationship between 25(OH)D3 levels with BMI (p=0.008; r= -0.0338), gender (p=0.001; r= -0.457), and total cholesterol levels (p=0.009); r= -0,391).Conclusions: There is a relationship between levels of 25(OH)D3 with BMI, the lower the 25(OH)3 blood level, the higher the risk of increasing BMI. Further research is still needed to ensure that giving vitamin D to obese populations can reduce body weight or BMI.
Comparison of Enterprise stent 2 with 1 in assisting coiling of ruptured aneurysms: a real-world study
Authors: Li Zhenbao , Xuan Jianwei , Fang Xinggen , Zhao Xintong , Zhang Bingbing , Wu Degang , Lai Niansheng , Liu Jiaqiang , Zhang Zihuan , Yuan Jinlong , Qin Feiyun 
Published: June 2022

Aim:
To investigate the effectiveness and safety of the Enterprise 2 (E2) stent versus the Enterprise 1 (E1) stent in treating ruptured intracranial aneurysms (RIAs) in China.
Materials & methods:
The authors conducted an electronic medical record analysis for patients with RIAs who underwent E1/E2 deployment. The main outcomes were immediate complete occlusion (ICO), patient functional outcomes, complications and aneurysm recurrence.
Results:
Stent deployment was successful in all patients (E2: 90; E1: 270). ICO and patients with good functional outcomes at discharge were similar between E2 and E1 (80.0% vs 75.1% and 78.7% vs 81.1%, respectively). The E2 group had a significantly lower complication rate compared with the E1 group (7.8% vs 16.4%; odds ratio: 0.36; 95% CI: 0.15–0.91; p = 0.031). By 6 months post-discharge, the two groups had comparable patient functional outcomes and aneurysm recurrence (E2 vs E1: 80.2% vs 81.9% and 13.3% vs 14.9%).
Conclusion:
Compared with the E1 stent, the E2 stent had similar effectiveness but a lower complication risk in treating RIAs.
Assessment of Drug prescription Pattern in pregnancy in A Tertiary Care Hospital: A Prospective Study
Authors: Hedieh Vafaeerokh  , Mohammed Kazim Sheriff  
Published: June 2022

Pregnancy is a special physiological condition and managing medical conditions during pregnancy is a challenge due to the teratogenic potential of many drugs. This cross-sectional prospective study was conducted for a period of 6 months to describe the prescription pattern and risk categorization of drugs among pregnant inpatients in a tertiary care hospital. Pregnant inpatients of OBG ward in any trimester who were prescribed with at least one drug were included. Demographic details and list of prescribed drugs were collected from medical records of patients. The drugs prescribed were grouped according to their pharmacological classes and US FDA pregnancy risk classification. Prescription pattern was assessed using WHO core prescribing indicators. A total of 951 drugs comprising 34 different drugs were prescribed for 420 pregnant women. The average number of drugs prescribed per encounter was 2.3 ± 0.9 (SD). Anti- anemic/vitamin and mineral supplements (288, 30.3%), followed by antibiotics (142, 14.93%) and antihypertensive drugs (127, 13.35%) were the most commonly prescribed classes of drugs. As per FDA Drug Risk Category, most of prescribed drugs belonged to category B (42.26%) and category A (32.9%) followed by category C (17%), category D (1.05%) and category X (0.84%). It was found that the overall prescription pattern of drugs among pregnant inpatients was safe and rational since the majority of prescribed drugs fell under category A and B pregnancy. Continuous drug utilization evaluation in this population and interaction of clinical pharmacist with healthcare team is crucial to have rational and safe prescription of drugs among hospitalized pregnant women.