bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of GSTM1 and GSTT1 genes insertion/deletion polymorphism with colorectal cancer risk: a case-control study of Khyber Pakhtunkhwa population Pakistan
Authors: Zubair Hina , Aurangzeb Javeria , Zubair Bushra , Imran Muhammad 
Published: February 2022

Objective: To evaluate the genetic association of glutathione S transferase M1 and glutathione S transferase T1 genes insertion/deletion polymorphism with the risk of colorectal cancer.
Method: This case-control study was conducted March 2018 and November 2019 at the University of Peshawar, Peshawar, Pakistan, and comprised blood samples from colorectal cancer patients and age- and gender-matched controls. Deoxyribonucleic acid was extracted from blood samples, and glutathione S transferase M1 and glutathione S transferase T1 genotyping was performed using polymerase chain reaction at the Institute of Radiation and Nuclear Medicine, Peshawar. Data regarding age, gender, location, smoking status, cancer stage and node involvement was collected on a predesigned proforma. Data was analysed using Minitab 17.
Results: The frequency of glutathione S transferase M1 was was significantly associated with colorectal cancer risk (p<0.01), while glutathione S transferase T1 null genotype showed non-significant association (p<0.43). The association between the combined deletion of glutathione S transferase M1 and glutathione S transferase T1 polymorphism and the colorectal risk was significant (p=0.011). Glutathione S transferase M1 and glutathione S transferase T1 deletions had non-significant association with age, smoking status, dwelling and tumour location (p>0.05) when compared with the wild genotypes in colorectal cancer cases.
Conclusion: Glutathione S transferase M1 gene deletion was found to be associated with the risk of colorectal cancer development.
Key Words: Colorectal cancer, Detoxification, GSTM1, GSTT1, Polymorphism.
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Effectiveness of adapted cognitive behaviour therapy for dysthymia: an evidence based case study
Authors: Sameera Shafiq  , Zaqia Bano  , Shahid Sharif Randhawa  , Khalid Hayat Khan  , Qurat-ul-Ain Muhammad  , Abdullah Muhammad  
Published: February 2022

Several empirical researches imply that cognitive behaviour therapy can be effective in treating psychiatric disorders. In the context of Pakistan, some researches with Culturally Adapted Cognitive Behaviour Therapy were found to be effective for depression, anxiety, bipolar and psychotic disorders. The present study theoretically underpinned the model of Adapted Cognitive Behaviour Therapy (ACBT) based on the inclusion of Tasbeehs (Rosary) derived from the Quran and Sunnah to be fruitful in producing the desirable change in a single case of Dysthymia with anxious distress which was assessed with the help of the Urdu versions of Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Beck Hopelessness Scale (BHS) and Beck Scale for Suicidal Ideation (BSS). ACBT produced profound differences in pre-test and post-test scores in a patient. The Tasbeeh or Rosary could provide a therapeutic means for treating psychiatric illnesses irrespective of the religious and cultural differences.
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Tirofiban and Rivaroxaban use in the management of right coronary artery thrombus as a primary manifestation of essential thrombocythemia
Authors: Muhummad Nasir Rahman  , Javed Maleeha 
Published: February 2022

A 45 year old male with hypertension was presented to our centre with a recent inferior wall myocardial infarction (IWMI) and post infarction angina. Invasive coronary angiography revealed an occluded proximal right coronary artery (RCA) with high thrombus burden, in the absence of obstructive disease in the remaining coronary vasculature. Based on raised platelet counts of 923,000/microliter and positive Janus kinase (JAK 2- V617) mutations tested by polymerase chain reaction (PCR), a diagnosis of essential thrombocythemia (ET) was made. A therapeutic strategy of aspiration thrombectomy along with I/V Tirofiban was used for three days, followed by reassessed angiogram and percutaneous coronary intervention (PCI) with drug eluting stent (DES) placement was applied.
In addition to dual antiplatelet and statin therapy, patient was treated with Rivaroxaban 15 mg once daily for a month and Hydroxyurea 500mg twice daily. At one month follow up, patient was asymptomatic,
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Sub-Acute Thyroiditis presenting as pyrexia of unknown origin, a rare case with literature review
Authors: Rubina Mukhtar  
Published: February 2022

Pyrexia of unknown origin (PUO) is a challenging entity in medical practice from a diagnostic point of view. Sub-Acute Thyroiditis (SAT), that is an inflammatory condition of thyroid, self-limiting and easily treatable, is a very rare cause for PUO with a few published cases and unfortunately not considered in routine for the differential diagnosis (DD) of PUO. Usually, it presents with mild thyrotoxicosis signs and symptoms, painful goiter, and rarely with cervical Lymph adenopathy. Thyroid antibodies might be negative, but inflammatory markers are usually raised. Anti-inflammatory drugs (NSAID) and steroids are a simple but very effective treatment. We present our experience for diagnosing and treating a female patient presenting with PUO. She was diagnosed as a case of sub-acute Thyroiditis on nuclear thyroid scan, High resolution ultrasound (HR-USG) of Thyroid and radioimmunoassay (RIA) for thyroid hormones and thyroid antibodies.
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Incidence and Risk Factors for Musculoskeletal Injuries among Indonesian Junior Badminton Athletes during a National Elite Championship
Authors: Suryanto Finna A. , Widyahening Indah Suci , Tobing Ade Jeanne 
Published: February 2022

Objective. This study aimed to investigate the incidence and risk factors for musculoskeletal injuries among junior badminton athletes during a national championship.
Methods. A retrospective cohort study was conducted among 128 junior badminton athletes who were members of one Indonesian badminton club and participated in the National Premier Circuit held in June 2019 in West Java, Indonesia. Data on demographic characteristics, history of previous and current injuries, physical examination, diagnosis (type, anatomical structure involved, and location), and treatment of injuries were collected along with data on the format of the game (single, double, or combination), and the number of matches for each respective athlete. Measures of injury frequency used were the incidence proportion and clinical incidence. Determinant factors for incidence were investigated.
Results. Twenty-four injury events involving 23 athletes were recorded, with an incidence proportion of 23/128 athletes (18%) and a clinical incidence of 24/128 athletes or 18.8 per 100 athletes. Acute injuries were more frequent (13/24, 54.2%) than chronic/overuse injuries. More than half (14/24, 58.3%) of the injuries occurred in the lower extremities. Factors that increased the risk of injury were age ≥ 15 years (relative risk [RR] = 6.26, 95% confidence interval [CI] 1.96, 20.04, p < 0.001), and the number of matches ≥ 3 (RR = 3.79, 95% CI 1.61, 8.92, p = 0.001).
Conclusion. Musculoskeletal injuries occurred frequently among Indonesian junior badminton athletes during the national elite championship. An effective injury-prevention program specific to young athletes should be developed to maintain their future participation and performance in competition.
Analysis of Length of Hospital Stay of Road Crash Patients in the Philippine General Hospital’s Integrated Surgical Information System from 2008–2017
Authors: Herbosa Teodoro J. , Lu Jinky Leilanie , Lu Sophia Francesca 
Published: February 2022

Introduction. Mobility in the Philippines has increasingly become a major issue especially with the growing economy of the country. Collisions on the road cannot be entirely avoided; thus, we focus our efforts to reducing road crashes that result in death and serious injuries. To do this, we analyzed road crash patients brought to the Philippine General Hospital (PGH).
Objective. The study aimed to quantify how crash factors affect length of hospital stay (LOS) of patients brought to PGH, as well as to look for associations between the LOS and demographic and clinical variables.
Methods. This is a retrospective study using database of patients admitted in PGH from 2008 to 2017. The study focused on LOS, which was used as the dependent variable for Poisson regression and Kruskal-Wallis H tests. The determinants considered in the study are socio-demographic variables such as age, sex, civil status, victim type, vehicle type, patient classification, and region of incidence, as well as clinical variables such as consult type, outcome of the patient, body parts injured, Glasgow coma score (GCS), among others.
Results. We analyzed data of 4979 road crash patients from the PGH database. We found that civil status, age, patient classification, vehicle type, and province were associated with LOS. For the clinical variables, consult type, primary service, outcome of patient, body injuries, GCS and systolic blood pressure were found significant. Poisson regression suggests longer hospital stay for patients with injuries sustained in the head and neck (RR = 1.102, p < 0.001), face (RR = 1.218, p < 0.001), and extremity (RR = 1.673, p < 0.001).
Conclusion. Results show that injury sustained in certain parts of the body such as head and neck, face, and extremity significantly affect LOS. Results also show that subgroups within demographic variables affect LOS. There is a need to address the ever-increasing number of road crash patients and implications to length of hospitalization.
Prevalence of CYP2C19 681G>A and 636G>A Gene Polymorphisms in Javanese Farmers Exposed to Chlorpyrifos
Authors: Liem Jen Fuk , Mansyur Muchtaruddin , Malik Safarina G. , Suryandari Dwi A. , Soemarko Dewi S. , Subekti Imam , Suyatna Franciscus D. , Kekalih Aria , Pangaribuan Bertha 
Published: February 2022

Objective. The objective of our study was to determine the genotype frequencies of CYP2C19*2 and *3 gene polymorphisms among Javanese farmers exposed to chlorpyrifos (CPF) in Central Java, Indonesia.
Methods. This cross-sectional study was conducted from July to October 2020 in Central Java, Indonesia, involving 151 vegetable farmers aged 18-65 years who used CPF for at least one year. CYP2C19*2 and *3 gene polymorphisms were analyzed using PCR-RFLP. Direct calculations were applied to calculate allele and genotype frequencies. The difference in genotype frequencies among the sex and cumulative exposure level (CEL) group was performed using the Chi-square test. In contrast, the proportion difference of allele frequencies was analyzed using Z-test.
Results. The frequency of CYP2C19 genotypes *1/*1, *1/*3, *1/*2, and *2/*2 were 64 %, 7 %, 23 % and 6 %. We observed no significant difference in the genotype distribution according to sex group and CEL group.
Conclusion. In summary, the prevalence of toxicologically relevant CYP2C19 polymorphisms was determined in the Javanese agricultural population. The CYP2C19 genotype may be helpful as an essential biomarker of genetic susceptibility towards CPF exposure. Nevertheless, further studies to confirm the role of CYP2C19 in this context are still needed.
EU E A PILHA DE MULHERES MORTAS: RESSIGNIFICAÇÃO DE IDENTIDADES FEMININAS EM MULHERES EMPILHADAS (2019), DE PATRÍCIA MELO
Authors: Grinko Pezzini Paula , Kaminski Alves Lourdes 
Published: February 2022

No contexto de uma América Latina pós-moderna, representações artísticas produzidas por mulheres buscam romper com discursos sacralizados pela tradição do cânone ocidental, principalmente em relação às identidades femininas. Em Mulheres empilhadas (2019), Patrícia Melo mobiliza categorias como “mulher” e “violência” para pensar na sociedade brasileira como partícipe de um sistema moderno colonial de gênero. Nesse sentido, pretendemos explicitar e analisar as estratégias narrativas utilizadas pela autora, com destaque à diversidade de formas discursivas e ao posicionamento da protagonista, em direção à expansão das potencialidades da literatura de autoria feminina. Partimos de teorias feministas de cunho decolonial; portanto, autoras como Zilá Bernd (1998), Tânia Pellegrini (2001), Zulma Palermo (2005), María Lugones (2014) e Florencia Garramuño (2014) fundamentam as discussões propostas.
Greater Occipital Nerve Block with Local Anesthetics and Corticosteroids in Treatment-Resistant Chronic Migraine
Authors: Cvetkovic Vlasta Vukovic , Icco Roberto De , Do Thien Phu , Pellesi Lanfranco , Ashina Messoud , Hansen Jakob Møller 
Published: February 2022

Objective: We investigated the efficacy and tolerability of greater occipital nerve block with lidocaine plus betamethasone in adults with chronic migraine in whom two or more previous preventive treatments were unsuccessful.
Methods: Ten participants were enrolled in a 24-weeks, randomized, double-blind, placebo-controlled, crossover trial conducted at a single tertiary headache center in Copenhagen (Denmark). After a 4-week run-in period, participants underwent treatment with bilateral greater occipital nerve block with lidocaine plus betamethasone (GONb) or lidocaine plus saline (placebo) with a 4-week interval wash-out phase between the 8-week crossover periods. The primary aim was to compare the number of migraine days during crossover periods after GONb or placebo. This trial is registered at ClinicalTrials.gov (NCT02686983).
Results: This study was stopped before achieving the a priori sample size, due to a slow enrollment. Ten participants were recruited, completed the study and were included in the analyses. At the baseline, the mean number of monthly migraine days was 22.9 (range, 14-30). No difference between GONb and placebo on the reduction of monthly migraine days was observed (p = 0.147; 95% CI between 0.6 and 3.7 days). Adverse events were recorded in two patients after GONb, compared with three patients after placebo.
Conclusions: GONb is not beneficial in patients with difficult-to-treat chronic migraine.
Migrânea e comportamento suicida: cronificação como mecanismo intermediário e associação com depressão e sintomas cognitivo-comportamentais no ataque
Authors: Kotsifas Nikolai José Eustátios , Utiumi Marco Antonio Takashi , Canalli Filho Luiz Carlos , Küster João Guilherme Bochnia , Godk Keryn Sporh , Santos Maria Luiza dos , Piovesan Elcio Juliato 
Published: February 2022

Introdução
A migrânea é frequentemente associada à ideação/tentativa de suicídio na literatura, porém, há uma carência de estudos nacionais.
Objetivos
Explorar a associação entre comportamento suicida e migrânea em três centros nacionais.
Material e métodos
Estudo transversal em ambulatórios especializados. Pacientes com migrânea episódica (ME) e crônica (MC) foram convidados consecutivamente. Acompanhantes, funcionários e pacientes de ambulatórios de Dermatologia sem cefaleia foram convidados como controles. A ideação suicida (IS) foi pesquisada pelas escalas Patient Health Questionnaire-9 (PHQ-9, últimas duas semanas) e Columbia-Suicide Severity Rating Scale (C-SSRS, últimos dois meses). A tentativa de suicídio (TS) ao longo da vida foi explorada pela C-SSRS. Aprovado pelo CEP/HC/UFPR 2.732.610.
Resultados
Incluímos 297 indivíduos (MC 116, ME 101, controle 80) dos quais 41-57 (PHQ-9 e C-SSRS; 13,8-19,2%) com IS e 35 (11,8%) com TS. A proporção de IS foi maior no grupo MC em relação aos controles (PHQ-9: 21,6% vs. 6,2% p=0,006; C-SSRS: 26,7% vs. 10,0% p=0,005; regressão simples) e, pela PHQ-9, em comparação com ME (21,6% vs. 10,9% p=0,038). A proporção de TS foi marginalmente superior em MC comparados com controles (17,2% vs. 7,5% p=0,054). Para a análise multivariada agregamos a ocorrência de IS e/ou TS como comportamento suicida (CS) e, para fins de inferência causal, ajustamos cinco confundidores de acordo com um gráfico acíclico dirigido. A probabilidade de CS sofre efeito da MC em comparação com controles (OR 2,69; IC95% 1,23-6,24). Um modelo preditivo com o subgrupo migranoso demonstrou que depressão (OR 4,48; IC95% 2,12-9,78) e piora de sintomas cognitivo-comportamentais (OR 1,42; IC95% 1,12-1,83) no ataque estão associados com CS.
Conclusões
A cronificação parece ter um papel no surgimento do comportamento suicida em migranosos. Depressão e sintomas cognitivo-comportamentais no ataque servem como sinais de alerta.
Existem diferenças de gênero na dor no pescoço e nos distúrbios musculoesqueléticos da coluna cervical associados à migrânea?
Authors: Xavier Nathan da Silva , Benatto Mariana Tedeschi , Florencio Lidiane Lima , Fernández-de-las-Peñas César , Dach Fabiola , Bevilaqua-Grossi Débora 
Published: February 2022

Introdução
Dor cervical e disfunções musculoesqueléticas parecem estar associadas à migrânea. No entanto, os estudos que investigaram essas associações foram realizados majoritariamente em mulheres.
Objetivo
Verificar se migranosos apresentam diferenças entre os gêneros em relação à dor e incapacidade no pescoço, no desempenho dos músculos flexores profundos da cervical e na mobilidade passiva da coluna cervical superior.
Métodos
A amostra foi composta por 30 homens e 30 mulheres, com idade entre 18 e 55 anos, com diagnóstico de migrânea de acordo com a Classificação Internacional de Cefaleia. Foram excluídos indivíduos com diagnóstico de outras cefaleias ou doenças sistêmicas. Os participantes foram questionados sobre a presença de dor no pescoço e aqueles que relataram sintomas responderam ao questionário Neck Disability Index (NDI). Foi realizado o Flexion Rotation Test (FRT) para avaliar a mobilidade da coluna cervical superior e o Craniocervical Flexion Test (CCFT), para avaliar o desempenho dos músculos flexores profundos da coluna cervical. O estudo foi aprovado pelo Comitê de Ética em Pesquisa (HCRP n°6644/2018).
Resultados
A comparação entre os grupos foi realizada usando os testes t de Student e qui-quadrado. A razão de prevalência também foi calculada e um nível de significância de p<0,05 foi adotado. As mulheres apresentaram maior relato de dor cervical (p=0,04) e uma associação ao risco 1,69 maior em relatar esse sintoma em relação aos homens (p=0,02). No entanto, os grupos não apresentaram diferenças significativas na incapacidade cervical pelo NDI (p=0.25), na mobilidade pelo FRT (p=0,92) e no desempenho pelo CCFT (p=0,52).
Conclusão
Mulheres com migrânea apresentam maior prevalência de relato de dor cervical, no entanto os testes clínicos da coluna cervical não diferem entre os gêneros. Portanto, os achados desse estudo apontam para a necessidade de avaliação da coluna cervical para um manejo terapêutico adequado em ambos os sexos.
Perfil psicossocial de indivíduos com disfunção temporomandibular (DTM) atendidos no projeto de extensão alívio
Authors: Silvestre Natália Wandekoeken , Sarcinelli Carlos Henrique Cardoso , Cazelli Ana Giulia Prado , Santuzzi Cintia Helena , Souza Dhandara Araújo De , Liberato Fernanda Mayrink Gonçalves 
Published: February 2022

Introdução
As disfunções temporomandibulares (DTM) são condições que frequentemente evoluem para cronicidade e o perfil psicossocial do indivíduo pode contribuir para o seu prognóstico.
Objetivos
Traçar o perfil psicossocial de pacientes com DTM atendidos no Projeto Multiprofissional de Dor Orofacial da Universidade Federal do Espírito Santo (Alívio).
Material E Métodos
Trata-se de um estudo descritivo retrospectivo, aprovado no Comitê de Ética em Pesquisa (CAAE: 48433621.1.0000.5060). Foram analisados dados dos pacientes no período de novembro de 2020 a agosto de 2021.
Para análise do perfil psicossocial tivemos como base: Índice de Qualidade do sono de Pittsburgh (PSQI); Cinesiofobia (TAMPA); Hábitos orais (OBC); Hipervigilância (PVAQ); Catastrofização (PCS), a prática e o tipo de atividade física realizada. Os resultados foram analisados através de média, desvio padrão e frequência.
Resultados
Compuseram a amostra 18 indivíduos dos quais 66,7% apresentaram distúrbio do sono (PSQI); 66,7% apresentavam baixa cinesiofobia (TAMPA), 83,3% demonstraram hábitos orais que representam alto risco em desenvolver DTM (OBC); hipervigilância (PVAQ) com média de pontuação 56,78 (16,3) de um total de 80 pontos; 38,9% foram classificados com baixo nível catastrofização (PCS); 55,6% praticavam atividade física, destes, 33,6% tinham como hábito a prática de caminhada. A análise psicossocial de pacientes com DTM considera aspectos psicológicos e sociais no início e prognóstico desse transtorno. Logo, faz-se necessária uma abordagem psicossocial e multidisciplinar para entender e abordar fatores além dos físicos que repercutem no prognóstico da condição.
Conclusão
O presente estudo observou que existe uma relação que pacientes com DTM dispõe de uma predominância de distúrbio do sono, baixa cinesiofobia, hábitos orais relacionados a alto risco de desenvolver DTM, hipervigilância com pontuação média, baixo nível de catastrofização e a prática de atividade física é moderada.
Incapacidade cervical está relacionada à presença de aura e frequência de crises de migrânea
Authors: Tolentino Gabriella de Almeida , Pinheiro Carina Ferreira , Florencio Lidiane Lima , Fernández-de-las-Peñas César , Dach Fabíola , Bevilaqua-Grossi Débora 
Published: February 2022

Introdução
A cervicalgia é altamente prevalente em migranosos, e um potencial contribuinte para a incapacidade relacionada à cefaleia. Além disso, indivíduos com migrânea crônica apresentam maior incapacidade cervical, entretanto não é conhecido se esta relação também se manifesta em indivíduos com aura.
Objetivo
Avaliar as características da cervicalgia em mulheres com migrânea com e sem aura e migrânea crônica.
Métodos
Este estudo transversal incluiu 102 mulheres entre 18 e 55 anos de idade. Destas, 70 foram divididas em três grupos de acordo com o diagnóstico: migrânea sem aura (MSA, n=22), migrânea com aura (MCA, n=17) e migrânea crônica (MC, n=31). Mulheres sem cefaleia compuseram o grupo controle (GC, n=32). As participantes foram questionadas quanto às características clínicas da cefaleia e da cervicalgia. As voluntárias com relato de cervicalgia completaram o questionário Neck Disability Index, para avaliação da incapacidade relacionada à dor cervical. O estudo foi aprovado pelo comitê de ética e pesquisa (CAAE 59620716.2.0000.5440).
Resultados
As variáveis de desfecho foram comparadas entre os grupos por meio de ANOVA one-way e Teste de Qui-quadrado (p<0,05). O relato de cervicalgia foi maior nos grupos migranosos (GC 25%, MSA 50%, MCA 100% e MC 81%, p<0,001). Quanto às características da cervicalgia, o grupo MC apresentou maior frequência de cervicalgia (21,1 dias/mês, DP 8,1), comparado ao grupo MSA (9,2 dias mês, DP 10,5; p=0,003). Além disso, maior incapacidade cervical foi observada no grupo MC comparado ao MSA e GC, e no grupo MCA comparado ao GC (GC 5,4 pontos, DP 5,4; MSA 9,9 pontos, DP 4,2; MCA 14,8 pontos, DP 6,1; MC 16,5 pontos, DP 7,0; p<0.001).
Conclusão
Embora a frequência de cervicalgia seja alta nos pacientes com migrânea crônica, a prevalência de cervicalgia e a incapacidade cervical são maiores em migranosos com aura e migrânea crônica.