bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer palliative care referral: patients’ and family caregivers’ perspectives – a systematic review
Authors: Patra Lipika , Ghoshal Arunangshu , Damani Anuja , Salins Naveen 
Published: November 2022

BackgroundDespite the evidence of palliative care benefits, referrals are infrequent and delayed. Patients and their caregivers are essential stakeholders in the referral process with valuable perspectives. This review systematically explored their perceived facilitators and barriers to palliative care referral.Methods4 subject-specific databases (PubMed, Cumulative Index to Nursing and Allied Health Literature, PsycINFO and EMBASE), 3 multidisciplinary databases (SCOPUS, Web of Science and Cochrane database) and 11 journals from 1 January 1990 to 31 May 2022 were searched; and scored for their methodological rigour using Hawker’s tool. Findings were synthesised using Popay’s Narrative Synthesis method and interpreted using decision-making theory.Results4 themes were generated from 14 studies: (1) The timing of referral should be right and communication must be comprehensive. Delays in initiating serious illness conversations, prognostication, and decision-making hindered referral. In contrast, the presence of symptoms facilitated it. (2) Referral was equated to death, and as an inferior form of treatment, a rebranding might mitigate the stigma. (3) Referral made families feel emotional and devastated; explanation and team initiatives enabled the normalisation and positive coping. (4) Long-term holistic palliative care facilitated a positive care experience and a sense of reassurance and satisfaction, enabling a smooth transition from curative to comfort care. The late referral was associated with perceived inadequate symptom management, diminished quality of life and death and complicated bereavement issues.ConclusionPatients’ and caregivers’ predisposition to palliative care engagement was influenced by timely referral, comprehensive communication, perception and stigma about palliative care. Longitudinal association with the palliative care team mitigated negative perceptions and improved satisfaction and coping.PROSPERO registration numberCRD42018091481.
Single-cell genomics illustrates heterogeneous phenotypes of myocardial fibroblasts under ischemic insults
Authors: Thankam Finosh G. , La Vy , Agrawal Devendra K. 
Published: November 2022

Myocardial regenerative strategies are promising where the choice of ideal cell population is crucial for successful translational applications. Herein, we explored the regenerative/repair responses of infarct zone cardiac fibroblast(s) (CF) by unveiling their phenotype heterogeneity at single-cell resolution. CF were isolated from the infarct zone of Yucatan miniswine that suffered myocardial infarction, cultured under simulated ischemic and reperfusion, and grouped into control, ischemia, and ischemia/reperfusion. The single-cell RNA sequencing analysis revealed 19 unique cell clusters suggesting distinct subpopulations. The status of gene expression (log2 fold change (log2 FC) > 2 and log2 FC < −2) was used to define the characteristics of each cluster unveiling with diverse features, including the pro-survival/cardioprotective (Clusters 1, 3, 5, 9, and 18), vasculoprotective (Clusters 2 and 5), anti-inflammatory (Clusters 4 and 17), proliferative (Clusters 4 and 5), nonproliferative (Clusters 6, 8, 11, 16, 17, and 18), proinflammatory (Cluster 6), profibrotic/pathologic (Clusters 8 and 19), antihypertrophic (Clusters 8 and 10), extracellular matrix restorative (Clusters 9 and 12), angiogenic (Cluster 16), and normal (Clusters 7 and 15) phenotypes. Further understanding of these unique phenotypes of CF will provide significant translational opportunities for myocardial regeneration and cardiac management.
Observational imprints of our lost twin anti-universe
Authors: Barroso Bellido Samuel , Da̧browski Mariusz P. 
Published: November 2022

AbstractWe consider observational consequences of the entanglement between our universe and a hypothetical twin anti-universe in the third quantization scheme of the canonical quantum gravity in order to make such a scenario falsifiable. Based on our recent and unique investigations we select some special form of the interuniversal interaction which allows the entanglement entropy of the pair of universes to diverge at the critical points of their classical evolution where the specific behaviour of the Hubble parameter plays the key role. We find that the modification of the cosmic microwave background (CMB) power spectrum due to the entanglement with our twin anti-universe for such models is enlarged for small modeskand small multipole numbersl. Our specific form of the interaction is then constrained by the Planck satellite data giving the interaction coupling constant bound to be$$\lambda _o\lesssim {\mathcal {O}}(10^{-56})\,\text {s}^{-3}$$λo≲O(10-56)s-3which is small, but not negligible compared to the inflationary contribution. Some other coupling functions which allow more critical points are also briefly commented on in the context of their observational effect on CMB and other prospective observational data.
An isotropic extension of Einstein’s universe solution through gravitational decoupling
Authors: Andrade J. , Santana D. 
Published: November 2022

AbstractIn this work, we use the gravitational decoupling framework through the extended minimal geometric deformation to construct and study a new interior isotropic extension of Einstein’s universe solution. The resulting model fulfills the fundamental physical acceptance conditions. As well, we study the energy exchange between the Einstein’s fluid distribution and an extra perfect fluid which supports the resulting isotropic stellar configuration.
Ultrasensitive Troponin I and Incident Cardiovascular Disease
Authors: Empana Jean-Philippe , Lerner Ivan , Perier Marie-Cécile , Guibout Catherine , Jabre Patricia , Bailly Karine , Andrieu Muriel , Climie Rachel , van Sloten Thomas , Vedie Benoit , Geromin Daniela , Marijon Eloi , Thomas Frederique , Danchin Nicolas , Boutouyrie Pierre , Jouven Xavier 
Published: November 2022

Background:
To examine the association of ultrasensitive cTnI (cardiac troponin I) with incident cardiovascular disease events (CVDs) in the primary prevention setting.

Methods:
cTnI was analyzed in the baseline plasma (2008–2012) of CVD-free volunteers from the Paris Prospective Study III using a novel ultrasensitive immunoassay (Simoa Troponin-I 2.0 Kit, Quanterix, Lexington) with a limit of detection of 0.013 pg/mL. Incident CVD hospitalizations (coronary heart disease, stroke, cardiac arrhythmias, deep venous thrombosis or pulmonary embolism, heart failure, or arterial aneurysm) were validated by critical review of the hospital records. Hazard ratios were estimated per log-transformed SD increase of cTnI in Cox models using age as the time scale.

Results:
The study population includes 9503 participants (40% women) aged 59.6 (6.3) years. cTnI was detected in 99.6% of the participants (median value=0.63 pg/mL, interquartile range, 0.39–1.09). After a median follow-up of 8.34 years (interquartile range, 8.0–10.07), 516 participants suffered 612 events. In fully adjusted analysis, higher cTnI (per 1 SD increase of log cTnI) was significantly associated with CVD events combined (hazard ratio, 1.18 [1.08–1.30]). Among all single risk factors, cTnI had the highest discrimination capacity for incident CVD events (C index=0.6349). Adding log cTnI to the SCORE 2 (Systematic Coronary Risk Evaluation) risk improved moderately discriminatory capacity (C index 0.698 versus 0.685; bootstrapped C index difference: 0.0135 [95% CI, 0.0131–0.0138]), and reclassification of the participants (categorical net reclassification index, 0.0628 [95% CI, 0.023–0.102]). Findings were consistent using the US pooled cohort risk equation.

Conclusions:
Ultrasensitive cTnI is an independent marker of CVD events in the primary prevention setting.
What Happened to the K–12 Education Labor Market During COVID? The Acute Need for Better Data Systems
Authors: Bleiberg Joshua F. , Kraft Matthew A. 
Published: November 2022

Abstract
The COVID-19 pandemic upended the U.S. education system in ways that dramatically affected the jobs of K–12 employees. However, there remains considerable uncertainty about the nature and degree of staffing challenges during the pandemic. We draw on data from the Bureau of Labor Statistics (BLS) and State Education Agencies (SEA) to describe patterns in K–12 education employment and to highlight the limitations of available data. Data from the BLS suggest overall employment in the K–12 labor market declined by 9 percent at the onset of the pandemic and remained well below pre-pandemic levels more than two years later. SEA data suggest that teachers did not leave the profession en masse as many predicted, with turnover decreasing in the summer of 2020 and then increasing modestly in 2021 back to pre-pandemic levels. We explore possible explanations for these patterns including weak hiring through the summer of 2020 and high attrition among K–12 instructional support and noninstructional staff. State vacancy data also suggest that schools faced substantial challenges filling open positions during the 2021–22 academic year. Our analyses illustrate the imperative to build nationally representative, detailed, and timely data systems on the K–12 education labor market to better inform policy.
A Comparison of Beamforming and Direction Finding Algorithms (Beamscan and MUSIC) on a Linear Array HF Radar in a Medium to Low Wave Energy Environment
Authors: Cahl Douglas , Voulgaris George , Leonard Lynn 
Published: November 2022

Abstract
We assess the performance of three different algorithms for estimating surface ocean currents from two linear array HF radar systems. The delay-and-sum beamforming algorithm, commonly used with beamforming systems, is compared with two direction-finding algorithms: Multiple Signal Classification (MUSIC) and direction finding using beamforming (Beamscan). A 7-month dataset from two HF radar sites (CSW and GTN) on Long Bay, South Carolina (United States), is used to compare the different methods. The comparison is carried out on three locations (midpoint along the baseline and two locations with in situ Eulerian current data available) representing different steering angles. Beamforming produces surface current data that show high correlation near the radar boresight (R2 ≥ 0.79). At partially sheltered locations far from the radar boresight directions (59° and 48° for radar sites CSW and GTN, respectively) there is no correlation for CSW (R2 = 0) and the correlation is reduced significantly for GTN (R2 = 0.29). Beamscan performs similarly near the radar boresight (R2 = 0.8 and 0.85 for CSW and GTN, respectively) but better than beamforming far from the radar boresight (R2 = 0.52 and 0.32 for CSW and GTN, respectively). MUSIC’s performance, after significant tuning, is similar near the boresight (R2 = 0.78 and 0.84 for CSW and GTN) while worse than Beamscan but better than beamforming far from the boresight (R2 = 0.42 and 0.27 for CSW and GTN, respectively). Comparisons at the midpoint (baseline comparison) show the largest performance difference between methods. Beamforming (R2 = 0.01) is the worst performer, followed by MUSIC (R2 = 0.37) while Beamscan (R2 = 0.76) performs best.
Risk factors for mental disorder development in asylum seekers and refugees resettled in Western Europe and Turkey: Participant-level analysis of two large prevention studies
Authors: Barbui Corrado , Tedeschi Federico , Acarturk Ceren , Anttila Minna , Au Teresa , Baumgartner Josef , Carswell Ken , Churchill Rachel , Cuijpers Pim , Karyotaki Eirini , Klein Thomas , Koesters Markus , Lantta Tella , Nosè Michela , Ostuzzi Giovanni , Pasquini Massimo , Prina Eleonora , Sijbrandij Marit , Tarsitani Lorenzo , Turrini Giulia , Uygun Ersin , Välimäki Maritta , Walker Lauren , Wancata Johannes , White Ross G. , Purgato Marianna 
Published: November 2022

Background: In asylum seekers and refugees, the frequency of mental disorders, such as depression, anxiety and post-traumatic stress disorder, is higher than the general population, but there is a lack of data on risk factors for the development of mental disorders in this population. Aim: This study investigated the risk factors for mental disorder development in a large group of asylum seekers and refugees resettled in high- and middle-income settings. Methods: Participant-level data from two randomized prevention studies involving asylum seekers and refugees resettled in Western European countries and in Turkey were pooled. The two studies randomized participants with psychological distress, but without a diagnosis of mental disorder, to the Self-Help Plus psychological intervention or enhanced care as usual. At baseline, exposure to potentially traumatic events was measured using the Harvard Trauma Questionnaire-part I, while psychological distress and depressive symptoms were assessed with the General Health Questionnaire and the Patient Health Questionnaire. After 3 and 6 months of follow-up, the proportion of participants who developed a mental disorder was calculated using the Mini International Neuropsychiatric Interview. Results: A total of 1,101 participants were included in the analysis. At 3- and 6-month follow-up the observed frequency of mental disorders was 13.51% (115/851) and 24.30% (207/852), respectively, while the frequency estimates after missing data imputation were 13.95% and 23.78%, respectively. After controlling for confounders, logistic regression analysis showed that participants with a lower education level ( p = .034), a shorter duration of journey ( p = .057) and arriving from countries with war-related contexts ( p = .017), were more at risk of developing mental disorders. Psychological distress ( p = .004), depression ( p = .001) and exposure to potentially traumatic events ( p = .020) were predictors of mental disorder development. Conclusions: This study identified several risk factors for the development of mental disorders in asylum seekers and refugees, some of which may be the target of risk reduction policies. The identification of asylum seekers and refugees at increased risk of mental disorders should guide the implementation of focused preventative psychological interventions.
Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial
Authors: Lindsay Cameron , Humphreys Ioan , Phillips Ceri , Pandyan Anand 
Published: November 2022

Objective To estimate the cost-consequence of treating spasticity early with botulinum toxin in the acute stroke unit. Design Secondary cost-consequence analysis, using data from a double-blind randomised-controlled trial. Setting Single-centre specialised stroke unit. Subjects and Interventions Patients with Action Research Arm Test grasp-score of <2 and who developed spasticity within six weeks of a first stroke were randomised to receive injections of: 0.9% sodium-chloride solution (placebo) or onabotulinumtoxin-A (treatment). Main measures Resource use costs were calculated for the study. Mean contracture costs for each group were calculated. The Barthel Index and Action Research Arm Test were used to generate a cost per unit of improvement. Results There were no significant differences associated with early treatment use. The mean contracture cost for the treatment group was £817 and for the control group was £2298 (mean difference = −£1481.1(95% CI −£2893.5, −£68.7) ( p = 0.04). The cost per unit of improvement for the Barthel Index was −£1240 indicating that the intervention costs less and is more effective. The cost per unit of improvement for the Action Research Arm Test was −£450 indicating that the intervention costs less and is more effective. Conclusions Treating spasticity early in stroke patients at risk of contractures with botulinum toxin leads to a significant reduction in contracture costs. The cost per improvement of Barthel and Action Research Arm Test indicates that the intervention costs less and is more effective. Trial Registration data EudraCT(2010-021257-39) and ClinicalTrials.gov-Identifier:NCT01882556.
Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials
Authors: Zhang Fan , Wang Hui , Bai Yan , Huang Liuyan , Zhang Huachun 
Published: November 2022

Objective This systematic review and meta-analysis aimed to evaluate the effect of respiratory muscle training on respiratory muscle strength, lung function, cardiopulmonary fitness, and quality of life for chronic kidney disease patients. Methods PubMed, Embase, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials published randomized controlled trials that evaluated the effect of respiratory muscle training for chronic kidney disease patients from inception to December 2021, and rerun on September 2022. The quality of included studies was evaluated according to the Cochrane Collaboration's risk of bias tool-2. The outcomes were analyzed as mean differences with a fixed/random effect model. The strength of evidence was evaluated with the Grading of Recommendation, Assessment, Development, and Evaluation approach. Results Eleven randomized controlled trials were included. All but two of the studies were in hemodialysis patients. The follow-up time range was 4 to 12 weeks. Compared to controls, respiratory muscle training significantly improved maximal expiratory pressure (mean difference = 17.36, p = 0.013), maximal inspiratory pressure (mean difference = 18.26, p = 0.002), forced expiratory volume at 1 second (mean difference = 0.20, p= 0.020), forced vital capacity (mean difference = 0.26, p = 0.008), but not for 6-minute walk test (mean difference = 39.85, p= 0.138). Conclusions As a non-pharmacological therapy, respiratory muscle training can effectively improve maximal expiratory pressure, maximal inspiratory pressure, forced expiratory volume at 1 second, and forced vital capacity in patients with chronic kidney disease and is safe for such populations.
Post-operative pain following percutaneous nephrolithotripsy- clinical correlates
Authors: Lotan Paz , Goldberg Hanan , Nevo Amihay , Darawsha Abd Elhalim , Gefen Sheizaf , Criederman Gherman , Rubinstein Roy , Herzberg Haim , Holland Ronen , Lifshitz David , Golomb Dor 
Published: November 2022

Objectives: Management of postoperative pain following percutaneous nephrolithotripsy (PCNL) is a significant goal. We sought to identify risk factors and clinical correlates of postoperative pain in order to improve perioperative management and patient satisfaction. Materials and methods: A single-center, retrospective analysis, from a prospectively maintained database, of all consecutive patients who underwent PCNL for renal calculi between January 2011 and August 2018. Postoperative pain was assessed using the visual analog scale (VAS) and analgesic use. We considered VAS score above 4 as meaningful. Pain management was standardized according to patirnt reported VAS scores. Multivariable logistic regression was performed to identify risk factors and clinical correlates. Results: A total of 496 patients were analyzed. Younger age was associated with VAS above 4 on the operative day and the first postoperative following PCNL ( p = 0.003 and p < 0.001, respectively). Female gender was associated with VAS above 4 in the first 2 days following the operation ( p < 0.001). Conclusions: Younger age and female gender would most likely benefit from pre-emptive improved pain management protocols following PCNL.
Living with risk: Retired couples’ experiences of a financialised retirement income system
Authors: Austen Siobhan , Broomhill Ray , Costa Monica , Sharp Rhonda 
Published: November 2022

AbstractThis paper presents new data on the nature and consequences of the risks for retirees inherent in the Australian retirement income system. This system can be regarded as ‘financialised’ in that retirement savings are primarily managed by non-government financial institutions and, although the Age Pension remains as a safety net, responsibility for the provision and management of retirement incomes has increasingly shifted to individuals. In this article we report the results of a qualitative study of older mixed-sex couple households’ experiences of this system and discuss the implications for retirement incomes policy. We conclude that while the system of government-mandated employer superannuation contributions (the Superannuation Guarantee) is undoubtedly raising the living standard of many older Australians, the financialised nature of the retirement income system, as a whole, poses significant financial risks for many retirees.
DESSRT: A Novel Framework for Empirical Red Teaming at Scale
Authors: Behlendorf Brandon , Ackerman Gary 
Published: November 2022

Background Red Teaming is widely used to discover vulnerabilities, test defensive measures, and anticipate emerging but novel threats. It has rarely been conducted both systematically and at scale, substantially limiting confidence in its results and the generalizability of its findings. Aim We introduce distributed, empirical, systematic, and scalable red teaming (DESSRT), a framework for translating tactical-level Red Teaming into a replicable research methodology. We apply DESSRT to address whether the information about and availability of computed tomography (CT) scanners influences adversary decision-making in aviation security. Method Using a convenience sample of 143 university students, participants role-played as adversaries in an eight-hour attack planning exercise. Via a custom instrument, participants were randomly assigned across three adversary profiles built on historical cases and then designed a simulated attack. Afterwards, one of three injects about CT scanners were randomly assigned, and participants were asked about potential changes in attack plans (including target changes). Differences among assigned profiles and CT scanner injects were evaluated using standard statistical tests of association. Results Although differences in explosive and weapon package selections were not statistically significant across profiles, security evasion methods were. Following injects, participants were equally as likely to change tactics across profiles, with the majority (53%) changing at least one tactical area. When asked, the majority (18) of those who changed targets (27/143) reported that the additional information on CT scanners did have some effect on their target change decision. Conclusion Overall, the DESSRT framework provides a novel mechanism for translating traditional Red Teaming exercises into a replicable and empirical research method. Although not a replacement for historical data, where available, DESSRT allows analysts and researchers to test theories about human decision-making, generate novel what-if insights to support planning efforts, and validate parameters within complex models.