bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attraction or Repelling Effects of Commercial Plant Essential Oils on the Synanthropic Cheiracanthium mildei (Araneae: Cheiracanthiidae)
Authors: Gloríková Nela , Skuhrovec Jiří , Nový Pavel , Klouček Pavel , Řezáč Milan 
Published: June 2022

Abstract
The northern yellow sac spider Cheiracanthium mildei L. Koch, is expanding its range to Central Europe, especially to synanthropic habitats. The spiders become unwanted companions because of the unreasonable fear – arachnophobia, and estetic reason – silk retreats in corners, capturing dust. The most commonly used substances against spiders are pesticides, which are, however, toxic. In our work we tested the attraction or repellence of 15 essential oils (EO) from plants representing eight families to C. mildei. Our research has shown a significant repellent effect of EO from three plants, namely Syzygium aromaticum (L.) Merr. et L. M. Perry (Myrtales: Myrtaceae), Ananas comosus (L.) Merr. (Poales: Bromeliaceae) and Musa sp. (L.) (Zingiberales: Musaceae). In contrast, some EOs appeared to have an attraction effect, particularly Carum carvi L. (Apiales: Apiaceae). Zingiber officinale Roscoe (Zingiberales: Zingiberaceae) reduced the tendency of spiders to construct the silken retreat. S. aromaticum, A. sativus, Musa sp. and Z. officinale have the potential to be used as natural repellents against spiders.
The Associations of Multivitamin and Antioxidant Use With Mortality Among Women and Men Diagnosed With Colorectal Cancer
Authors: Figueiredo Jane C , Guinter Mark A , Newton Christina C , McCullough Marjorie L , Um Caroline Y , Patel Alpa V , Campbell Peter T 
Published: June 2022

Abstract

Background
Colorectal cancer survivors often use multivitamins and other over-the-counter dietary supplements, but evidence is limited regarding their potential associations with mortality.

Methods
This prospective analysis included women and men from the Cancer Prevention Study-II Nutrition Cohort who were cancer-free at baseline (1992 or 1993) and diagnosed with colorectal cancer through June 2015. Detailed information on multivitamin use, vitamin C supplements, and vitamin E supplements was self-reported on questionnaires at baseline, in 1997, and every 2 years thereafter. Pre- and postdiagnosis data were available for 3176 and 2006 colorectal cancer survivors, respectively, among whom 2116 (648 from colorectal cancer) and 1256 (242 from colorectal cancer) died. Multivariable-adjusted Cox proportional hazards regression models examined associations. All statistical tests were 2-sided.

Results
Among colorectal cancer survivors, 49.7% and 58.5% reported multivitamin use before and after diagnosis, respectively (vitamin C use before and after diagnosis: 27.8% and 28.1%; vitamin E use before and after diagnosis: 27.5% and 29.4%, respectively). There were no statistically significant associations of pre- or postdiagnosis multivitamin use with all-cause, colorectal cancer-specific, or noncolorectal cancer mortality. Vitamin C was also not associated with any mortality outcomes. However, prediagnosis vitamin E use was associated with a non-statistically significant increased risk of all-cause mortality (multivariable adjusted hazard ratio = 1.08, 95% confidence intervals = 0.96 to 1.23) and all other noncolorectal cancer mortality (multivariable adjusted hazard ratio = 1.13, 95% confidence intervals = 0.97 to 1.31).

Conclusions
These results suggest that multivitamin use before or after diagnosis is not associated with mortality in colorectal cancer survivors. However, vitamin E use may be associated with increased risk of mortality and merits further investigation.
Novel bi-allelic variants in KASH5 are associated with meiotic arrest and non-obstructive azoospermia
Authors: Yang Chao , Lin Xiaoqi , Ji Zhiyong , Huang Yuhua , Zhang Ling , Luo Jiaqiang , Chen Huixing , Li Peng , Tian Ruhui , Zhi Erlei , Hong Yan , Zhou Zhi , Zhang Feng , Li Zheng , Yao Chencheng 
Published: June 2022

Abstract
KASH5 is an essential component of the LINC (linker of the nucleoskeleton and cytoskeleton) complex that regulates chromosome movements and nuclear envelope (NE) remodeling in mouse spermatocytes during meiosis prophase I, but its expression and function in human cells, as well as its association with male infertility are largely unknown. In this study, a novel heterozygous copy number variation (CNV) (seq [GRCh37] del(19) (19q13.33) chr19: g.49894043-49903011del) and a heterozygous loss of function variant (NM_144688: c.979_980del: p.R327Sfs*21) in human KASH5 were identified in a non-obstructive azoospermia (NOA)-affected patient and in his infertile sister by whole-exome sequencing and CNV array. Spermatogenesis in the proband was arrested at zygotene-like stage with a deficiency in homolog pairing and synapsis. KASH5 protein expression in human spermatocytes was evaluated and reported first in this study. Single-cell RNA sequencing demonstrated that the LINC complex and associated genes in human and mouse shared a similar expression pattern, indicating a conserved mechanism in the regulation of chromosome movements and NE remodeling. Kash5 knockout mouse displayed similar phenotypes, including a meiotic arrest at a zygotene-like stage and impaired pairing and synapsis. Collectively, we have identified novel rare variants within human KASH5 in patients with NOA and meiosis arrest. Our study expands the knowledge of KASH5 and associated proteins in regulating human meiosis prophase I progress and provides new insight into the genetic etiology of NOA.
Evolution of humoral lesions on follow-up biopsy stratifies the risk for renal graft loss after antibody-mediated rejection treatment
Authors: Bouchet Antonin , Muller Brieuc , Olagne Jerome , Barba Thomas , Joly Mélanie , Obrecht Augustin , Rabeyrin Maud , Dijoud Frédérique , Picard Cécile , Mezaache Sarah , Sicard Antoine , Koenig Alice , Parissiadis Anne , Dubois Valérie , Morelon Emmanuel , Caillard Sophie , Thaunat Olivier 
Published: June 2022

ABSTRACT

Background
The standard-of-care protocol, based on plasma exchanges, high-dose intravenous immunoglobulin and optimization of maintenance immunosuppression, can slow down the evolution of antibody-mediated rejection (AMR), but with high interindividual variability. Identification of a reliable predictive tool of the response to AMR treatment is a mandatory step for personalization of the follow-up strategy and to guide second-line therapies.

Methods
Interrogation of the electronic databases of 2 French university hospitals (Lyon and Strasbourg) retrospectively identified 81 renal transplant recipients diagnosed with AMR without chronic lesions (cg score ≤1) at diagnosis and for whom a follow-up biopsy had been performed 3–6 months after initiation of therapy.

Results
The evolution of humoral lesions on follow-up biopsy (disappearance versus persistence versus progression) correlated with the risk for allograft loss (logrank test, P = .001). Patients with disappearance of humoral lesions had ∼80% graft survival at 10 years. The hazard ratio for graft loss in multivariate analysis was 3.91 (P = .04) and 5.15 (P = .02) for patients with persistence and progression of lesions, respectively. The non-invasive parameters classically used to follow the intensity of humoral alloimmune response (evolution of immunodominant DSA mean fluorescence intensity) and the decline of renal graft function (estimated glomerular filtration rate decrease and persistent proteinuria) showed little clinical value to predict the histological response to AMR therapy.

Conclusion
We conclude that invasive monitoring of the evolution of humoral lesions by the mean of follow-up biopsy performed 3–6 months after the initiation of therapy is an interesting tool to predict long-term outcome after AMR treatment.
Emphasizing the importance of using cold-ironing technology by determining the share of hotelling emission value within the total emission
Authors: Kose S , Sekban D M 
Published: June 2022

Abstract
Considering the number of deaths due to air pollution, it is clear that it poses a great danger to public health. Sources that cause air pollution can be divided into two groups: natural resources (such as desert storms, fires and volcanic eruptions) and artificial sources (residences, industrial sector and motor vehicles), which cause a much higher rate of air pollution than natural resources. It is known that air pollutants originating from ships and port operations have an important share among vehicle sourced pollutants. Considering the emissions from both ships and operational reasons and their proximity to human habitats, it is obvious that port regions are important points in terms of emissions harmful to human health. The use of cold-ironing technology in ports instead of providing the energy needed from ship auxiliary machinery during the hotelling period at the port is the most effective method used to reduce the amount of ship-sourced emissions in the port area. On the other hand, it is seen that the number of ports where cold-ironing technology is used, which is extremely effective in reducing emissions harmful to human health, is quite limited. In this context, the share of the emission amount during the hotelling period in the total emission amount in the port area was calculated according to ship type and duration of hotelling in the port, and the importance of the use of cold-ironing technology in reducing the port-originated emissions was emphasized.
Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation
Authors: Lu Xuan , Chen Lunhao , Jiang Chao , Cao Kelei , Gao Zhihua , Wang Yue 
Published: June 2022

Abstract
Lumbar disc herniation (LDH) is a major cause of sciatica. Emerging evidence indicated that inflammation induced by the herniated nucleus pulposus (NP) tissues plays a major role in the pathogenesis of sciatica. However, the underlying mechanisms are still elusive. Although microglia and macrophages have been implicated in nerve injury–induced neuropathic pain, their roles in LDH-induced sciatica largely remain unknown. This study successfully established and modified a mouse model of LDH. We found that nerve root compression using degenerated NP tissues can initiate remarkable and persistent sciatica, with increased and prolonged macrophage infiltration in dorsal root ganglia (DRG) and significant activation of microglia in the spinal dorsal horn. Instead, compression of the nerve root with nondegenerated NP tissues only led to transient sciatica, with transient infiltration and activation of macrophages and microglia. Moreover, continuous treatment of PLX5622, a specific colony-stimulating factor 1 receptor antagonist, ablated both macrophages and microglia, which effectively alleviated LDH-induced sciatica. However, mechanical allodynia reoccurred along with the repopulation of macrophages and microglia after the withdrawal of PLX5622. Using RNA sequencing analysis, the current study depicted transcriptional profile changes of DRG after LDH and identified several macrophage-related potential target candidates. Our results suggested that microglia and macrophages may play an essential role in the development and maintenance of LDH-induced sciatica. Targeting microglia and macrophages may be a promising treatment for chronic LDH-induced sciatica.
Integrating Interprofessional Collaborative Practice Into Occupational and Environmental Health and Safety Education
Authors: McCullagh Marjorie C. , Valentín-Cortés Mislael A. , D'Souza Clive , Batterman Stuart A. , Neitzel Richard , Zhen Harry , O'Neill Marie S. 
Published: June 2022

Objective
Although occupational health and safety programs are expected to prepare graduates to function in an interprofessional collaborative environment, research to support training in this area is far less common in this discipline than among clinical programs. We incorporated interprofessional education (IPE) competencies into an occupational health and safety course for graduate students in diverse disciplines (public health, engineering, nursing) and evaluated effectiveness.

Methods
We assessed course offerings for content learning and attitudes toward IPE and analyzed data using a mixed-methods approach.

Results
In general, students increased their understanding of the role of other disciplines, confidence in working in interprofessional teams, and valuation of IPE.

Conclusion
Introducing IPE competencies into graduate education in worker health and safety is feasible and can equip students to more effectively work in occupational health–oriented multidisciplinary teams.
COVID-19 Infections in Health Care Personnel by Source of Exposure and Correlation With Community Incidence
Authors: Wight Elizabeth , Swift Melanie , O'Horo John C. , Hainy Caitlin , Molella Robin , Morrow Allison , Breeher Laura 
Published: June 2022

Objective
The aim of this study was to describe the rate of household, community, occupational, and travel-related COVID-19 infections among health care personnel (HCP).

Methods
In a retrospective cohort study of 3694 HCP with COVID-19 infections from July 5 to December 19, 2020, we analyzed infection source data and rates, compared with local and state infection rates, and performed a correlation analysis.

Results
Household (27.1%) and community (15.6%) exposures were the most common sources of infection. Occupational exposures accounted for 3.55% of HCP infections. Unattributable infections (no known exposure source) accounted for 53.1% and correlated with community rather than occupational exposure (R = 0.99 vs 0.78, P < 0.01).

Conclusions
COVID-19 infections in this large HCP cohort correlated closely with infection rates in the community. The low incidence of occupational infections supports the effectiveness of institutional infection prevention and control measures.
One Drop Improves Productivity for Workers With Type 2 Diabetes
Authors: Lavaysse Lindsey M. , Imrisek Steven D. , Lee Matthew , Osborn Chandra Y. , Hirsch Ashley , Hoy-Rosas Jamillah , Nagra Harpreet , Goldner Dan , Dachis Jeff , Sears Lindsay E. 
Published: June 2022

Objective
Diabetes research on work productivity has been largely cross-sectional and retrospective, with only one known randomized controlled trial (RCT) published, to our knowledge. Secondary analysis of the Fit-One RCT tested the effect of One Drop’s digital health program on workplace productivity outcomes, absenteeism, and presenteeism, for employees and specifically for older workers with type 2 diabetes.

Methods
Analysis of the 3-month Fit-One trial data from employees who have type 2 diabetes explored productivity using logistic analyses and generalized estimating equations.

Results
Treatment and control group comparisons showed that workers (N = 125) using One Drop see direct benefits to workplace productivity, which leads to productivity savings for employers.

Conclusion
This was the first RCT to demonstrate that a mobile health application for managing type 2 diabetes can positively affect productivity at work.
Five-Step Scapula Tip Flap Harvesting for Oromaxillofacial Defects Reconstruction
Authors: Gomez-Martinez de Lecea Cristina , Schweizer Riccardo , Thor Andreas , Rodriguez-Lorenzo Andres 
Published: June 2022

Summary:
In the last 10 years, there has been an increased focus on the scapula tip free flap for head and neck reconstructions. Its several advantages make it a versatile and reliable reconstructive option for patients with orofacial compound defects. The aim of this article is to present a systematic surgical approach for the harvesting of the scapula tip free flap. Herein, a step-by-step surgical approach and some technical tips are described to make the scapula tip flap dissection simpler, safer, and more straightforward.
Concentrations of Efavirenz, Tenofovir, and Emtricitabine in Obesity: A Cross-Sectional Study
Authors: Solanke Toyosi , Kamau Festus , Esterhuizen Tonya , Maartens Gary , Khoo Saye , Joska John A. , Kellermann Tracy , Strijdom Hans. , Decloedt Eric H. 
Published: June 2022

Background:
Obesity is increasing worldwide including in people living with HIV (PLWH). Antiretroviral pharmacokinetic data in obesity are limited.

Objectives:
To measure antiretroviral drug concentrations in obese and nonobese PLWH treated with the fixed-dose combination of efavirenz–tenofovir–emtricitabine. To determine pharmacokinetic differences across indicators of obesity and their associated immunovirological outcomes.

Methods:
We conducted a cross-sectional sample analysis of 2 cohort studies. We measured mid-dose efavirenz, 8-hydroxy-efavirenz, tenofovir, and emtricitabine concentrations. Antiretroviral drug concentrations were analyzed by body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR).

Results:
We performed a study of 213 participants: General obesity was detected in 20.4% using BMI and abdominal obesity in 53.6% using WC and 62.4% using WHR, respectively. The median concentrations of all antiretroviral drugs were lower among obese participants determined by BMI and WC, with efavirenz showing greater differences than tenofovir or emtricitabine. For BMI, results were most striking for efavirenz (1752.3 vs 2342.9 ng/mL, P = 0.002) with lower concentrations in obese participants. Using WC, efavirenz (1845.8 vs 2571.2 ng/mL, P < 0.001), tenofovir (65.8 vs 73.2 ng/mL, P = 0.036), and emtricitabine (159.5 vs 221.0 ng/mL, P = 0.005) concentrations were lower in obese participants. Eight-hydroxyefavirenz concentrations were similar in nonobese and obese participants for WC. Using WHR, the concentrations of all antiretroviral drugs were lower in the obese population, most strikingly for emtricitabine (173.5 vs 229.0 ng/mL, P = 0.015). There were no immunovirological associations.

Conclusion:
We found lower antiretroviral concentrations in all obese groups, most strikingly in participants with abdominal obesity determined by WC. Lower drug concentrations had no immunovirological associations.
Life after autoantibody-mediated encephalitis: optimizing follow-up and management in recovering patients
Authors: Turcano Pierpaolo , Day Gregory S. 
Published: June 2022

Purpose of review
Timely diagnosis and treatment is essential to optimize outcomes in patients with antibody-mediated encephalitis (AME); yet even with early diagnosis and treatment, long-term outcomes may still fall short of expectations. Identifying patients at greater risk of adverse outcomes is key to personalizing care, supporting accurate counseling of patients and family members, and informing therapeutic decisions in patients with AME. This review considers long-term outcomes in recovering patients, including approaches to measure and manage common sequelae that influence life after AME.

Recent findings
Cognitive impairment, fatigue, and sleep disturbances affect most recovering AME patients. This realization highlights the need for outcome measures that encompass more than motor function. Standardized questionnaires, surveys, and clinical assessment tools may be adapted to support comprehensive and reproducible clinical assessments and to identify patients who may benefit from additional therapies.

Summary

Good outcomes continue to be reported in recovering patients, emphasizing the high potential for recovery following AME. However, cognitive, behavioral, and physical sequelae may limit the potential for great outcomes following AME. Multidisciplinary follow-up is needed to recognize and treat sequelae that compromise long-term recovery and limit quality of life in recovering patients.
Progress in the mechanism of neuronal surface P antigen modulating hippocampal function and implications for autoimmune brain disease
Authors: Barake Francisca , Bravo-Zehnder Marcela , González Alfonso 
Published: June 2022

Purpose of review
The aim of this study was to present a new regulation system in the hippocampus constituted by the neuronal surface P antigen (NSPA) and the tyrosine phosphatase PTPMEG/PTPN4, which provides mechanistic and therapeutic possibilities for cognitive dysfunction driven by antiribosomal P protein autoantibodies in patients with systemic lupus erythematosus (SLE).

Recent findings
Mice models lacking the function of NSPA as an E3 ubiquitin ligase show impaired glutamatergic synaptic plasticity, decreased levels of NMDAR at the postsynaptic density in hippocampus and memory deficits. The levels of PTPMEG/PTPN4 are increased due to lower ubiquitination and proteasomal degradation, resulting in dephosphorylation of tyrosines that control endocytosis in GluN2 NMDAR subunits. Adult hippocampal neurogenesis (AHN) that normally contributes to memory processes is also defective in the absence of NSPA.

Summary
NSPA function is crucial in memory processes controlling the stability of NMDAR at PSD through the ubiquitination of PTPMEG/PTPN4 and also through AHN. As anti-P autoantibodies reproduce the impairments of glutamatergic transmission, plasticity and memory performance seen in the absence of NSPA, it might be expected to perturb the NSPA/PTPMEG/PTPN4 pathway leading to hypofunction of NMDAR. This neuropathogenic mechanism contrasts with that of anti-NMDAR antibodies also involved in lupus cognitive dysfunction. Testing this hypothesis might open new therapeutic possibilities for cognitive dysfunction in SLE patients bearing anti-P autoantibodies.
Cycling multisensory changes in migraine: more than a headache
Authors: Peng Kuan-Po , May Arne , Basedau Hauke 
Published: June 2022

Purpose of review
Research on migraine usually focuses on the headache; however, accumulating evidence suggests that migraine not only changes the somatosensory system for nociception (pain), but also the other modalities of perception, such as visual, auditory or tactile sense. More importantly, the multisensory changes exist beyond the headache (ictal) phase of migraine and show cyclic changes, suggesting a central generator driving the multiple sensory changes across different migraine phases. This review summarizes the latest studies that explored the cyclic sensory changes of migraine.

Recent findings
Considerable evidence from recent neurophysiological and functional imaging studies suggests that alterations in brain activation start at least 48 h before the migraine headache and outlast the pain itself for 24 h. Several sensory modalities are involved with cyclic changes in sensitivity that peak during the ictal phase.

Summary
In many ways, migraine represents more than just vascular-mediated headaches. Migraine alters the propagation of sensory information long before the headache attack starts.
Functional MRI in migraine
Authors: Messina Roberta , Gollion Cedric , Christensen Rune Häckert , Amin Faisal Mohammad 
Published: June 2022

Purpose of review
The underlying mechanisms of migraine are complex and heterogenous. Advances in neuroimaging techniques during the past few decades have contributed to our understanding of migraine pathophysiology. Brain function in migraine patients has been widely explored using functional MRI (fMRI). This review will highlight the major fMRI findings that characterize the different phases of migraine.

Recent findings
The migraine attack starts with hypothalamic hyperexcitability and early reorganization of the common ascending pain and central trigeminovascular pathways. Moreover, the visual cortex becomes hyperexcitable during the aura phase. During the headache phase, further disruptions of the pontine, thalamic, sensorimotor and visual networks occur, although the hypothalamic activity and connectivity normalizes. The visual cortex remains hyperexcitable during the postdromal phase. Asymptomatic migraine patients can also experience functional alternations of pain and visual processing brain areas. At present, the heterogeneity of the asymptomatic phase and fMRI findings make it difficult to find common denominator.

Summary
fMRI studies have captured functional brain changes associated with migraine phases, leading to an improvement of our understanding of migraine pathophysiology. Further MRI studies are needed to disclose whether the migraine attack is triggered by intrinsic brain dysfunction or external factors.