bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioral and performance response associated with administration of intravenous flunixin meglumine or oral meloxicam immediately prior to surgical castration in bull calves
Authors: Cull Charley A , Rezac Darrel J , DeDonder Keith D , Seagren Jon E , Cull Brooke J , Singu Vijay K , Theurer Miles E , Martin Miriam , Amachawadi Raghavendra G , Kleinhenz Michael D , Lechtenberg Kelly F 
Published: February 2022

AbstractThe objective of this study was to determine the effects of flunixin meglumine or meloxicam on behavioral response and performance characteristics associated with surgical castration in crossbred bulls. Intact male Bos taurus calves (n = 252; averaging 176 kg) were randomly allocated into one of three treatment groups within pen: control (CON), flunixin meglumine (FLU; 2.2 mg/kg intravenous injection), or meloxicam (MEL; 2.0 mg/kg per os). The individual animal was the experimental unit. Calves were individually weighed on days 0 and 14 of the trial to evaluate performance outcomes. On study day 0, treatments were administered, according to their random allocation, immediately prior to surgical castration using the Henderson tool method. Visual analog scale (VAS) assessment and categorical attitude score (CAS) were collected on days −1, 0 (6 h post-castration), 1, 2, 3, and 4 in the study. The VAS was assigned using a 100 mm horizontal line with “normal” labeled at one end of the line and “moribund” at the other end of the horizontal line. The masked observer assigned a mark on the horizontal line based upon the observed severity of pain exhibited by that individual animal. The CAS was assigned by the same observer using five different categories with a score of 0 being “normal”. Average daily gain tended (P = 0.09) to be associated with the treatment group, and MEL had a greater (P = 0.04) average daily gain through day 14 compared with CON. A significant (P &lt; 0.01) treatment by day interaction was indicated for VAS score, and MEL had lower VAS scores on days 0, 1, 2, and 3 post-castration compared with CON; FLU had lower VAS scores on days 0 and 1 compared with CON. A significant treatment by day interaction was not present (P = 0.25) for CAS. The FLU had lesser percent CAS ≥1 (17.5%; P = 0.05) compared with CON (29.4%); MEL has lesser percent CAS ≥1 observations (14.9%; P = 0.01) compared with CON. The median VAS increased as CAS was more severe. Results indicated MEL and FLU calves temporally improved behavioral responses following surgical castration with positive numerical trends for a 14 d average daily gain (ADG). The VAS system appeared to be an effective method of subjective evaluation of pain in beef calves in this study. Route of administration, duration of therapy, and low relative cost make oral meloxicam a reasonable analgesic treatment in calves when administered at the time of surgical castration.
Radioisotope-guided laparoscopy: a case report and description of an alternative surgical technique
Authors: Pinheiro Rodrigo Nascimento , Silvestrini Anderson Arantes , Rocha Gabriela El Haje Lobo , Heller Heloisa Lima , de Carvalho Gallo Pereira Camila , Furtado Rodrigo Guimarães 
Published: February 2022

Abstract
Prostate cancer is the second most frequent cancer type among men worldwide. With the development of Radiology and Nuclear Medicine technologies, early diagnosis is increasingly common, and the possibility of using new minimally invasive techniques increases. With a narrative review of the literature, this case report describes an alternative radioisotope-guided laparoscopy technique for tumors in the peritoneal cavity. There may be benefits in associating nuclear medicine techniques in the management of patients with non-palpable tumors that are difficult to locate in the peritoneal cavity, enabling the use of less invasive and safer surgical procedures for diagnosis, staging and treatment.
Disentangling the parameter space: the role of planet multiplicity in triggering dynamical instabilities on planetary systems around white dwarfs
Authors: Maldonado R F , Villaver E , Mustill A J , Chávez M 
Published: February 2022

ABSTRACT
Planets orbiting intermediate- and low-mass stars are in jeopardy as their stellar hosts evolve to white dwarfs (WDs) because the dynamics of the planetary system changes due to the increase of the planet:star mass ratio after stellar mass-loss. In order to understand how the planet multiplicity affects the dynamical stability of post-main sequence (MS) systems, we perform thousands of N-body simulations involving planetary multiplicity as the variable and with a controlled physical and orbital parameter space:equal-mass planets; the same orbital spacing between adjacent planet’s pairs; and orbits with small eccentricities and inclinations. We evolve the host star from the MS to the WD phase following the system dynamics for 10 Gyr. We find that the fraction of dynamically active simulations on the WD phase for two-planet systems is $10.2^{+1.2}_{-1.0}$–$25.2^{+2.5}_{-2.2}$ ${{\rm per\,cent}}$ and increases to $33.6^{+2.3}_{-2.2}$–$74.1^{+3.7}_{-4.6}$ ${{\rm per\,cent }}$ for the six-planet systems, where the ranges cover different ranges of initial orbital separations. Our simulations show that the more planets the system has, the more systems become unstable when the star becomes a WD, regardless of the planet masses and range of separations. Additional results evince that simulations with low-mass planets (1, 10 M⊕) lose at most two planets, have a large fraction of systems undergoing orbit crossing without planet losses, and are dynamically active for Gyr time-scales on the WD’s cooling track. On the other hand, systems with high-mass planets (100, 1000 M⊕) lose up to five planets, preferably by ejections, and become unstable in the first few hundred Myr after the formation of the WD.
Neoproterozoic Eclogite-to Granulite-Facies Transition in the Ubendian Belt, Tanzania, and the Timescale of Continental Collision
Authors: Morita Isamu , Tsujimori Tatsuki , Boniface Nelson , Flores Kennet E , Aoki Shogo , Aoki Kazumasa 
Published: February 2022

AbstractIn collision-type orogens, where high-pressure and ultrahigh-pressure (HP–UHP) metamorphism usually occurs, deeply subducted continental slabs with eclogitized mafic rocks often undergo recrystallization/overprinting with various geothermal gradients after the peak conditions at lower-to-middle-crustal levels. During the crustal stabilization, the transition from eclogite-to granulite-facies is common. We conducted metamorphic petrology and zircon geochronology on (1) bimineralic and (2) partially granulitized eclogites from the Neoproterozoic Ufipa Terrane (Southwestern Tanzania). Microtextural relationships and mineral chemistry define three metamorphic stages: eclogite metamorphism (M1), HP granulite-facies overprinting (M2), and amphibolite-facies retrogression (M3). The bimineralic eclogite has a basaltic composition and lacks M2 minerals. In contrast, the kyanite eclogite is characterized by a gabbro-dioritic whole-rock composition and contains inherited magmatic zircon. Although the matrix is highly granulitized, garnet and kyanite contain eclogite-facies mineral inclusions. Phase equilibria modeling revealed P–T conditions of 2.1–2.6 GPa and 650–860°C for the M1 stage and 1.4–1.6 GPa and 750–940°C for the M2 stage. Zircon with eclogite-facies mineral inclusions from the bimineralic eclogite lacks Eu anomaly in the REE patterns and yielded the M1 eclogite metamorphic age of 588 ± 3 Ma. Zircon overgrowths surrounding the inherited Paleoproterozoic magmatic cores in kyanite eclogite yielded 562 ± 3 Ma. A weak negative Eu anomaly in the REE patterns and the absence of eclogitic mineral inclusions suggest the zircon growths at the M2 HP granulite-facies metamorphic stage. These new data indicate an eclogite-to granulite-facies transition time of 26 ± 4 million years (Myr), suggesting a rate of HP rock exhumation toward a lower crustal level of 0.7–1.5 mm/year. Furthermore, the density evolution model indicates that buoyant host orthogneiss with low-density gabbro-dioritic eclogite plays an important role in carrying high-density basaltic eclogite. Our 2D thermomechanical modeling also suggests that a slab break-off with a lower angle subduction of &lt;20° triggers the exhumation of the HP slab sliver with 20–30 Myr eclogite-to granulite transition time of large HP–UHP terranes in major collision zones.
Activation and negative feedback regulation ofSlHY5transcription by the SlBBX20/21–SlHY5 transcription factor module in UV-B signaling
Authors: Yang Guoqian , Zhang Chunli , Dong Huaxi , Liu Xiaorui , Guo Huicong , Tong Boqin , Fang Fang , Zhao Yiyang , Yu Yunji , Liu Yue , Lin Li , Yin Ruohe 
Published: February 2022

AbstractIn tomato (Solanum lycopersicum) and other plants, the photoreceptor UV-RESISTANCE LOCUS 8 regulates plant UV-B photomorphogenesis by modulating the transcription of many genes, the majority of which depends on the transcription factor ELONGATED HYPOCOTYL 5 (HY5). HY5 transcription is induced and then rapidly attenuated by UV-B. However, neither the transcription factors that activate HY5 transcription nor the mechanism for its attenuation during UV-B signaling is known. Here, we report that the tomato B-BOX (BBX) transcription factors SlBBX20 and SlBBX21 interact with SlHY5 and bind to the SlHY5 promoter to activate its transcription. UV-B-induced SlHY5 expression and SlHY5-controlled UV-B responses are normal in slbbx20 and slbbx21 single mutants, but strongly compromised in the slbbx20 slbbx21 double mutant. Surprisingly, UV-B responses are also compromised in lines overexpressing SlBBX20 or SlBBX21. Both SlHY5 and SlBBX20 bind to G-box1 in the SlHY5 promoter. SlHY5 outcompetes SlBBX20 for binding to the SlHY5 promoter in vitro, and inhibits the association of SlBBX20 with the SlHY5 promoter in vivo. Overexpressing 35S:SlHY5-FLAG in the WT background inhibits UV-B-induced endogenous SlHY5 expression. Together, our results reveal the critical role of the SlBBX20/21-SlHY5 module in activating the expression of SlHY5, the gene product of which inhibits its own gene transcription under UV-B, forming an autoregulatory negative feedback loop that balances SlHY5 transcription in plants.
Do Short-Term Effects Predict Long-Term Improvements in Women Who Receive Manual Therapy or Surgery for Carpal Tunnel Syndrome? A Bayesian Network Analysis of a Randomized Clinical Trial
Authors: Liew Bernard X W , de-la-Llave-Rincón Ana I , Scutari Marco , Arias-Buría José L , Cook Chad E , Cleland Joshua , Fernández-de-las-Peñas César 
Published: February 2022

Abstract

Objective
The purpose of this study was to develop a data-driven Bayesian network approach to understand the potential multivariate pathways of the effect of manual physical therapy in women with carpal tunnel syndrome (CTS).

Methods
Data from a randomized clinical trial (n = 104) were analyzed comparing manual therapy including desensitization maneuvers of the central nervous system versus surgery in women with CTS. All variables included in the original trial were included in a Bayesian network to explore its multivariate relationship. The model was used to quantify the direct and indirect pathways of the effect of physical therapy and surgery on short-term, mid-term, and long-term changes in the clinical variables of pain, related function, and symptom severity.

Results
Manual physical therapy improved function in women with CTS (between-groups difference: 0.09; 95% CI = 0.07 to 0.11). The Bayesian network showed that early improvements (at 1 month) in function and symptom severity led to long-term (at 12 months) changes in related disability both directly and via complex pathways involving baseline pain intensity and depression levels. Additionally, women with moderate CTS had 0.14-point (95% CI = 0.11 to 0.17 point) poorer function at 12 months than those with mild CTS and 0.12-point (95% CI = 0.09 to 0.15 point) poorer function at 12 months than those with severe CTS.

Conclusion
Current findings suggest that short-term benefits in function and symptom severity observed after manual therapy/surgery were associated with long-term improvements in function, but mechanisms driving these effects interact with depression levels and severity as assessed using electromyography. Nevertheless, it should be noted that between-group differences depending on severity determined using electromyography were small, and the clinical relevance is elusive. Further data-driven analyses involving a broad range of biopsychosocial variables are recommended to fully understand the pathways underpinning CTS treatment effects.

Impact
Short-term effects of physical manual therapy seem to be clinically relevant for obtaining long-term effects in women with CTS.
Exploring Inertial-Based Wearable Technologies for Objective Monitoring in Sports-Related Concussion: A Single-Participant Report
Authors: Powell Dylan , Stuart Samuel , Godfrey Alan 
Published: February 2022

AbstractObjectiveChallenges remain in sports-related concussion (SRC) assessment to better inform return to play. Reliance on self-reported symptoms within the Sports Concussion Assessment Tool means that there are limited data on the effectiveness of novel methods to assess a player’s readiness to return to play. Digital methods such as wearable technologies may augment traditional SRC assessment and improve objectivity in making decisions regarding return to play.MethodsThe participant was a male university athlete who had a recent history of SRC. The single-participant design consisted of baseline laboratory testing immediately after SRC, free-living monitoring, and follow-up supervised testing after 2 months. The primary outcome measures were from traditional assessment (eg, Sports Concussion Assessment Tool and 2-minute instrumented walk/gait test; secondary outcome measures were from remote (free-living) assessment with a single wearable inertial measurement unit (eg, for gait and sleep).ResultsThe university athlete (age = 20 years, height = 175 cm, weight = 77 kg [176.37 lb]) recovered and returned to play 20 days after SRC. Primary measures returned to baseline levels after 12 days. However, supervised (laboratory-based) wearable device assessment showed that gait impairments (increased step time) remained even after the athlete was cleared for return to play (2 months). Similarly, a 24-hour remote gait assessment showed changes in step time, step time variability, and step time asymmetry immediately after SRC and at return to play (1 month after SRC). Remote sleep analysis showed differences in sleep quality and disturbance (increased movement between immediately after SRC and once the athlete had returned to play [1 month after SRC]).ConclusionThe concern about missed or delayed SRC diagnosis is growing, but methods to objectively monitor return to play after concussion are still lacking. This report showed that wearable device assessment offers additional objective data for use in monitoring players who have SRC. This work could better inform SRC assessment and return-to-play protocols.ImpactDigital technologies such as wearable technologies can yield additional data that traditional self-report approaches cannot. Combining data from nondigital (traditional) and digital (wearable) methods may augment SRC assessment for improved return-to-play decisions.Lay SummaryInertia-based wearable technologies (eg, accelerometers) may be useful to help augment traditional, self-report approaches to sports-related concussion assessment and management by better informing return-to-play protocols.
Competency-Based Education and Practice in Physical Therapy: It’s Time to Act!
Authors: Timmerberg Jean Fitzpatrick , Chesbro Steven B , Jensen Gail M , Dole Robin L , Jette Diane U 
Published: February 2022

Abstract
Competency-based education (CBE) is a concept, a philosophy, and an approach to educational design where learner progression occurs when competency is demonstrated. It assumes a set of standard defined performance outcomes for any level of professional practice—students, residents, or practicing physical therapists. Those outcomes are based on the health needs of society and guide the curricular design, implementation, and evaluation of health professions education programs. Lack of a CBE framework—with no required demonstration of competence throughout one’s career—has the potential to lead to variation in physical therapists’ skills and to unwarranted variation in practice, potentially hindering delivery of the highest quality of patient care. CBE requires a framework that includes a commonly understood language; standardized, defined performance outcomes at various stages of learner development; and a process to assess whether competence has been demonstrated. The purpose of this perspective article is to (1) highlight the need for a shared language, (2) provide an overview of CBE and the impetus for the change, (3) propose a shift toward CBE in physical therapy, and (4) discuss the need for the profession to adopt a mindset requiring purposeful practice across one’s career to safely and most efficiently practice in a given area. Utilizing a CBE philosophy throughout one’s career should ensure high-quality and safe patient care to all—patient care that can adapt to the changing scope of physical therapist practice as well as the health care needs of society. The physical therapy profession is at a point at which we must step up the transition to a competency-based system of physical therapist education.
Diameters of phloem sieve elements can predict stem growth rates of woody plants
Authors: Tang Yunjia , Yin Shijiao , Pace Marcelo R , Gerolamo Caian S , Nogueira Anselmo , Zuntini Alexandre R , Lohmann Lúcia G , Plath Martin , Liesche Johannes 
Published: February 2022

Abstract
Understanding forest dynamics is crucial to addressing climate change and reforestation challenges. Plant anatomy can help predict growth rates of woody plants, contributing key information on forest dynamics. Although features of the water-transport system (xylem) have long been used to predict plant growth, the potential contribution of carbon-transporting tissue (phloem) remains virtually unexplored. Here, we use data from 347 woody plant species to investigate whether species-specific stem diameter growth rates can be predicted by the diameter of both the xylem and phloem conducting cells when corrected for phylogenetic relatedness. We found positive correlations between growth rate, phloem sieve element diameter and xylem vessel diameter in liana species sampled in the field. Moreover, we obtained similar results for data extracted from the Xylem Database, an online repository of functional, anatomical and image data for woody plant species. Information from this database confirmed the correlation of sieve element diameter and growth rate across woody plants of various growth forms. Furthermore, we used data subsets to explore potential influences of biomes, growth forms and botanical family association. Subsequently, we combined anatomical and geoclimatic data to train an artificial neural network to predict growth rates. Our results demonstrate that sugar transport architecture is associated with growth rate to a similar degree as water-transport architecture. Furthermore, our results illustrate the potential value of artificial neural networks for modeling plant growth under future climatic scenarios.
Molecular diagnosis contribution for personalized medicine
Authors: Luengo Olga , Galvan-Blasco Paula , Cardona Victoria 
Published: February 2022

Purpose of review
The purpose of the current review is to highlight the most recent findings in molecular allergy and its applicability in precision medicine for allergic patients.

Recent findings
Molecular allergy provides useful information in areas of respiratory allergy (house dust mites, pet dander and pollen allergy), food allergy (tree nuts, peanuts, fruits and vegetables), hymenoptera venom allergy and others, in order to improve management of patients. Regional differences in sensitization profiles, assay characteristics and interpretation of molecular sensitization in relation to whole extracts and total immunoglobulin E need to be taken into account. Studies of the impact of such strategies are needed.

Summary
Molecular allergy diagnosis represents a major contribution for personalized medicine. It aids in the assesment of risk prediction, disease severity, genuine/cross-reactive sensitization, and finally to apply precise management strategies.
Perforator-based Adipofascial Flaps and ADM: A Novel Combined Approach to Distal Lower Extremity Defects
Authors: Losco Luigi , Sereni Simone , Aksoyler Dicle , Spadoni Davide , Bolletta Alberto , Cigna Emanuele 
Published: February 2022

Background:
Due to the wide spectrum of lower extremity defect presentation, various reconstructive techniques are available. Classic adipofascial flaps are still a second choice. The authors described a new multistage reconstructive approach with perforator-based pedicled adipofascial flap.

Methods:
This retrospective study analyzed data of 23 patients undergoing adipofascial flap reconstruction after distal leg trauma between June 2017 and January 2020. A reconstructive approach with an adipofascial flap followed by a skin graft was used in all patients. Patients were divided into two treatment groups, and in only one treatment group, an acellular dermal matrix was placed above the adipofascial flap during the first stage of the reconstruction. Negative pressure wound therapy was applied to both groups. Surgical technique, outcomes, and complications were discussed.

Results:
All patients achieved complete healing, and no flap loss was reported. Minor complications occurred in four patients; all were treated conservatively on outpatient basis. The surgical and aesthetic results were evaluated as satisfactory from both patients and professionals. However, the group treated with acellular dermal matrix showed a lower complication rate, and resulted significantly more satisfied with the overall results and in several domains of the questionnaire administered postoperatively (P < 0.05).

Conclusions:
The adipofascial flap is a safe and effective approach for the reconstruction of small-to-medium-sized defects of the distal lower extremity. Our two-stage reconstructive approach maximizes the pearls offered by the established technique; the dermal matrix guarantees a layered reconstruction optimizing the surgical and aesthetic outcomes of the skin graft with minimal donor site morbidity.