bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTATION OF MUROTTAL AL-FATIHAH AGAINST CLIENTS RISK OF VIOLENCE AT THE CLENDER HOSPITAL, EAST JAKARTA
Authors: Amrullah  
Published: March 2022

Data from the World Health Organization (WHO) (2009) estimates that 450 million people worldwide experience mental disorders, about 10% of adults experience mental disorders and 25% of the population is estimated to experience mental disorders at a certain age during their life. This age usually occurs in young adults between the ages of 18-21 years. Other data from the National Institute of Mental Health shows that the rate of mental disorders reaches 13% of the disease as a whole and is expected to grow to 25% in 2030. The highest prevalence of mental disorders in Indonesia is in the province of the Special Capital Region (DKI) Jakarta (24, 3%), followed by Nagroe Aceh Darussalam (18.5%), West Sumatra (17.7%), NTB (10.9%), South Sumatra (9.2%), and Central Java (6.8%). while based on data Basic Health Research (2007). It shows that the national prevalence of mental disorders reaches 5.6% of the population, four to five people are suffering from mental illnesses. Based on these data, Indonesia's annual data that experience mental disorders is always increasing (MOH (2008). The increase in the proportion of mental disorders in the data obtained in Riskesdas 2018 is quite significant compared to Riskesdas in 2013, increasing from 1.7% to 7% of Indonesia's population (Riskesdas, 2018). In our country, there are approximately 2,400,000 children with mental disorders.
Risk stratification of indeterminate thyroid nodules by novel multigene testing: a study of Asians with a high risk of malignancy
Authors: Hu Chunfang , Jing Weiwei , Chang Qing , Zhang Zhihui , Liu Zhenrong , Cao Jian , Zhao Linlin , Sun Yue , Wang Cong , Zhao Huan , Xiao Ting , Guo Huiqin 
Published: March 2022

Molecular testing of indeterminate thyroid nodules informs about the presence of point mutations, insertions/deletions, copy number variants, RNA fusions, transcript alterations and miRNA expression. American Thyroid Association (ATA) guidelines suggest molecular testing of indeterminate thyroid nodules may be considered to supplement risk of malignancy (ROM). Although these recommendations have been incorporated in clinical practices in the United States, molecular testing of indeterminate thyroid nodules is not common practice in Asia. Here, we performed molecular testing of 140 indeterminate nodules from Chinese patients using a novel molecular platform composed of RNA and DNA‐RNA classifiers, which is similar to Afirma GEC and ThyroSeq v3. Compared with reports from North America, the new RNA and DNA‐RNA classifiers had a higher positive predictive value (p1 = 0.000 and p2 = 0.020) but a lower negative predictive value (p1 = 0.004 and p2 = 0.098), with no significant differences in sensitivity (p1 = 0.625 and p2 = 0.179) or specificity (p1 = 0.391 and p2 = 0.264). Out of 58 resected nodules, 10 were borderline and 33 malignant, indicating a 74.1% ROM, which was higher than reports in North America (10–40% ROM). Our findings emphasize molecular testing with the newly reported RNA and DNA‐RNA classifiers can be used as a ‘rule‐in’ test when ROM is high.
Direct Ink Writing: A 3D Printing Technology for Diverse Materials
Authors: Saadi M. A. S. R. , Maguire Alianna , Pottackal Neethu T. , Thakur Md Shajedul Hoque , Ikram Maruf Md. , Hart A. John , Ajayan Pulickel M. , Rahman Muhammad M. 
Published: March 2022

AbstractAdditive manufacturing (AM) has gained significant attention due to its ability to drive technological development as a sustainable, flexible, and customizable manufacturing scheme. Among the various AM techniques, direct ink writing (DIW) has emerged as the most versatile 3D printing technique for the broadest range of materials. DIW allows printing of practically any material, as long as the precursor ink can be engineered to demonstrate appropriate rheological behavior. This technique acts as a unique pathway to introduce design freedom, multifunctionality, and stability simultaneously into its printed structures. Here, a comprehensive review of DIW of complex 3D structures from various materials, including polymers, ceramics, glass, cement, graphene, metals, and their combinations through multimaterial printing is presented. The review begins with an overview of the fundamentals of ink rheology, followed by an in‐depth discussion of the various methods to tailor the ink for DIW of different classes of materials. Then, the diverse applications of DIW ranging from electronics to food to biomedical industries are discussed. Finally, the current challenges and limitations of this technique are highlighted, followed by its prospects as a guideline toward possible futuristic innovations.
Nitrogen‐Doped Carbon Fibers Embedded with Zincophilic Cu Nanoboxes for Stable Zn‐Metal Anodes
Authors: Zeng Yinxiang , Sun Peng Xiao , Pei Zhihao , Jin Qi , Zhang Xitian , Yu Le , Lou Xiong Wen (David) 
Published: March 2022

AbstractThe practical application of Zn‐metal anodes (ZMAs) is mainly impeded by the limited lifespan and low Coulombic efficiency (CE) resulting from the Zn dendrite growth and side reactions. Herein, a 3D multifunctional host consisting of N‐doped carbon fibers embedded with Cu nanoboxes (denoted as Cu NBs@NCFs) is rationally designed and developed for stable ZMAs. The 3D macroporous configuration and hollow structure can lower the local current density and alleviate the large volume change during the repeated cycling processes. Furthermore, zincophilic Cu and in‐situ‐formed Cu–Zn alloy can act as homogeneous nucleation sites to minimize the Zn nucleation overpotential, further guiding uniform and dense Zn deposition. As a result, this Cu NBs@NCFs host exhibits high CE of Zn plating/stripping for 1000 cycles. The Cu NBs@NCFs–Zn electrode shows low voltage hysteresis and prolonged cycling life (450 h) with dendrite‐free behaviors. As a proof‐of‐concept demonstration, a Zn‐ion full cell is fabricated based on this Cu NBs@NCFs–Zn anode, which demonstrates decent rate capability and improved cycling performance.
Constructing 3D Porous Current Collectors for Stable and Dendrite‐Free Lithium Metal Anodes
Authors: Li Dongdong , Chen Bin , Hu Henghui , Lai Wen‐Yong 
Published: March 2022

AbstractLithium metal batteries (LMBs) are considered promising candidates for the next‐generation rechargeable batteries due to the ultrahigh theoretical specific capacity (3860 mAh g−1) and the lowest negative electrochemical potential (−3.040 V versus the standard hydrogen anode) of lithium metal. However, the practical application of LMBs has been hindered by various serious challenges, especially the low cycling stability of lithium anodes due to the uncontrolled growth of lithium dendrites, unstable solid–electrolyte interphase, and excessive volume change of lithium metal. 3D lithium metal anodes with reduced local current density and alleviated volume expansion can be used to improve the safety performance of LMBs. The design of various 3D structures is therefore critical to achieve high‐performance lithium metal anodes. This review summarizes recent advances of several important 3D porous structures such as foam structures, parallel arrays, interweaved structures, coiled structures, Janus structures, gradient structures, and alloy frameworks for stable and dendrite‐free lithium metal anodes. The constructing strategies and modification methods of 3D lithium metal anodes are discussed in detail. The design and construction of novel 3D porous current collectors are expected to provide promising opportunities for the next‐generation of high‐energy‐density LMBs.
Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis
Authors: Li Yanjun , Li Juan , Li Zhuolin , Wei Mankun , Zhao Hezhao , Miyagishi Makoto , Wu Shourong , Kasim Vivi 
Published: March 2022

AbstractFerroptosis is a type of programmed cell death caused by disruption of redox homeostasis and is closely linked to amino acid metabolism. Yin Yang 2 (YY2) and its homolog Yin Yang 1 (YY1) are highly homologous, especially in their zinc‐finger domains. Furthermore, they share a consensus DNA binding motif. Increasing evidences have demonstrated the tumor suppressive effect of YY2, in contrast with the oncogenic YY1; however, little is known about the biological and pathological functions of YY2. Here, it is determined that YY2 induces tumor cell ferroptosis and subsequently suppresses tumorigenesis by inhibiting solute carrier family 7 member 11 (SLC7A11) transcription, leading to the decreased glutathione biosynthesis. Furthermore, YY2 and YY1 bind competitively to the same DNA binding site in the SLC7A11 promoter and antagonistically regulate tumor cell ferroptosis, thus suggesting the molecular mechanism underlying their opposite regulation on tumorigenesis. Moreover, mutations of YY2 zinc‐finger domains in clinical cancer patients abrogate YY2/SLC7A11 axis and tumor cell ferroptosis. Together, these results provide a new insight regarding the regulatory mechanism of ferroptosis, and a mechanistic explanation regarding the tumor suppressive effect of YY2. Finally, these findings demonstrate that homeostasis between YY1 and YY2 is crucial for maintaining redox homeostasis in tumor cells.
In Situ Monitored (N, O)‐Doping of Flexible Vertical Graphene Films with High‐Flux Plasma Enhanced Chemical Vapor Deposition for Remarkable Metal‐Free Redox Catalysis Essential to Alkaline Zinc–Air Batteries
Authors: Wu Zhiheng , Yu Yuran , Zhang Gongkai , Zhang Yongshang , Guo Ruxin , Li Lu , Zhao Yige , Wang Zhuo , Shen Yonglong , Shao Guosheng 
Published: March 2022

AbstractRechargeable zinc–air batteries (ZABs) have attracted great interests for emerging energy applications. Nevertheless, one of the major bottlenecks lies in the fabrication of bifunctional catalysts with high electrochemical activity, high stability, low cost, and free of precious and rare metals. Herein, a high‐performance metal‐free bifunctional catalyst is synthesized in a single step by regulating radicals within the recently invented high‐flux plasma enhanced chemical vapor deposition (HPECVD) system equipped with in situ plasma diagnostics. Thus‐derived (N, O)‐doped vertical few‐layer graphene film (VGNO) is of high areal population with perfect vertical orientation, tunable catalytic states, and configurations, thus enabling significantly enhanced electrochemical kinetic processes of oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) with reference to milestone achievements to date. Application of such VGNO to aqueous ZABs (A‐ZABs) and flexible solid‐state ZABs (S‐ZABs) exhibited high discharge power density and excellent cycling stability, which remarkably outperformed ZABs using benchmarked precious‐metal based catalysts. The current work provides a solid basis toward developing low‐cost, resource‐sustainable, and eco‐friendly ZABs without using any metals for outstanding OER and ORR catalysis.
A Review on the Synthesis and Applications of α‐Alkylidene Succinimides
Authors: Sakkani Nagaraju , Nanda Santosh Kumar 
Published: March 2022

AbstractThe widespread biological activity and manifestation of multiple reactive centers in itaconimides/α‐alkylidene succinimides have made them as one of the valuable synthetic targets. In this domain, various strategies have been developed to portray the proficiency of these N‐bearing heterocycles. The current review summarizes the biological activity, synthesis, and use of itaconimides/α‐alkylidene succinimide in numerous useful transformations under many reacting environments.
Comparison of captive and wild fascicularis‐group macaques (Primates, Cercopithecidae) provides insight into cranial form changes in response to rapid environmental changes
Authors: Arenson Julia L. , Simons Evan A. , Anderson Monya , Eller Andrea R. , White Frances J. , Frost Stephen R. 
Published: March 2022

AbstractObjectivesGeographic variation is an important feature among primates, but the mechanisms underlying it are not well understood. Macaques are geographically widespread and have been translocated to captive populations, providing a prime opportunity to evaluate changes in cranial form in response to a novel environment. Clinal variation was assessed among wild fascicularis‐group macaques and compared to two translocated populations to explore the relative contributions of developmental plasticity and microevolutionary forces in producing geographic variation in cranial form.Materials and MethodsForty‐five 3D coordinates over the cranium were taken on 380 wild macaques and 56 captive Macaca mulatta from Cayo Santiago, PR and Beaverton, OR. Geographic shape, represented by the singular warp scores from a two‐block partial least squares analysis, and centroid size were regressed against latitude, mean annual temperature, and mean annual precipitation among wild macaques. The two captive populations were compared to wild M. mulatta to assess potential changes in cranial form.ResultsSize and geographic shape were highly correlated with latitude in wild macaques, but neither ecological variable was important across the entire cline. Precipitation was important for shape only outside the tropics. Translocated M. mulatta are significantly larger, but not different in shape, compared to wild M. mulatta.DiscussionThese results are consistent with previous studies demonstrating cranial form is latitudinally variable among fascicularis‐group macaques, but the potential drivers remain unclear. Size is highly plastic while geographic shape has evolved differentiation at interpopulation and interspecific levels. Variation in cranial morphology likely arises first in size, followed relatively rapidly by evolved modifications to shape.
Catchment‐scale distribution, abundance, habitat use, and movements of European eel (Anguilla anguilla L.) in a small UK river: Implications for conservation management
Authors: Harwood Andrew J.P. , Perrow Martin R. , Sayer Carl D. , Piper Adam T. , Berridge Richard J. , Patmore Ian R. , Emson Dave , Cooper George 
Published: March 2022

Abstract

Effective conservation management of the Critically Endangered European eel (Anguilla anguilla) is hindered by incomplete understanding of distribution, abundance, and habitat requirements at the catchment scale.
All habitats available to eels within a small, highly regulated river catchment, representative of many used across the species' range, were sampled using several methods (including point abundance sample electric fishing and fyke nets) and supplemented by individual telemetry to investigate movements.
Eels were found throughout the catchment (59% of n = 131 sites) from the coastal marshes to the headwaters, although the probability of presence declined with distance from the estuary. The lack of a clear relationship with perceived barriers may illustrate a mismatch with the reality experienced by eels, as telemetry identified connectivity across obstacles between paludal habitat and estuary, and detected escapement of mature silver eels from both lotic and lacustrine habitat.
Different size/age classes occurred in different parts of the catchment, partly linked to different habitat associations, with coastal paludal habitat supporting >50% of the catchment population and especially smaller (possibly male dominated) yellow eels. Recently recruited elvers were most abundant in the lower reaches of lotic habitat. The largest (probably female) eels were concentrated in lacustrine sites, especially at the ‘end‐of‐the‐line’ in the headwaters.
Experiences here suggest that conservation management for eels in small catchments is best focused on: (i) improving connectivity and assisting migration of elvers across ‘problem’ barriers that cannot be removed or modified, (ii) river restoration and rewilding, especially measures that increase instream woody material to provide refuge habitat and, (iii) enhancement or creation (where necessary) of suitable lacustrine habitat to benefit large females in particular. Such action across numerous small river catchments may ultimately help support the recovery of eel stocks.
Silencing of Decapentaplegic (Dpp) gene inhibited the wing expansion in the white‐backed planthopper, Sogatella furcifera (Horváth) (Hemiptera: Delphacidae)
Authors: Long Gui‐Yun , Yang Jia‐Peng , Jin Dao‐Chao , Yang Hong , Zhou Cao , Wang Zhao , Yang Xi‐Bin 
Published: March 2022

AbstractThe Decapentaplegic gene controls wing patterning and spreading by regulating downstream genes in many insect species. However, the molecular characteristics, expression, and biological function of Dpp in Sogatella furcifera remain poorly understood. In this study, we cloned the Dpp gene from S. furcifera and examined its expression levels in different development stages, wing typed adults, and tissues. Then, the function of SfDpp gene was analyzed using an RNA interference (RNAi)‐based approach. The results showed that the full‐length complementary DNA of the SfDpp gene consists of 1034 bp and contains a 954‐bp open reading frame encoding 317 amino acids. SfDpp has a transforming growth factor‐β (TGF‐β) propeptide superfamily domain and a TGF‐β superfamily domain, typical of members of the TGF‐β superfamily. Quantitative real‐time polymerase chain reaction showed that the expression of SfDpp reached its highest expression level 40 min after eclosion. RNAi‐based gene silencing inhibited transcript levels of the corresponding messenger RNA in S. furcifera nymphs injected with double‐stranded RNA of SfDpp and resulted in death of 29.17% and 26.67% of 4th and 5th instar nymphs, respectively. The wing deformity rate of the adults was 74.12% and 3.41% after SfDpp gene silencing in 4th and 5th instar nymphs, respectively. Examining wing development‐associated genes showed that two target genes of Dpp (Vestigial and Spalt) were both dramatically downregulated after SfDpp was silenced. Our results demonstrate that downregulated SfDpp in early development causes wing expansion failure in S. furcifera. Thus, Dpp may be a target gene for restricting the migration of rice‐damaging planthoppers.
Anterior substitutional urethroplasty using a biomimetic poly‐l‐lactide nanofiber membrane: Preclinical and clinical outcomes
Authors: Song Lujie , Deng Kunxue , Yuan Wei , Zhang Jing , Lin Jiahao , Hu Xiaoyong , Huang Jianwen , Zhang Kaile , Zhang Haitao , Si Jiemin , Li Hongbin , Xu Tao , Fu Qiang 
Published: March 2022

AbstractThe aim of this study is to investigate the feasibility and efficacy of a novel biomimetic poly‐l‐lactide (PLLA) nanofiber membrane in repairing anterior urethral strictures from both preclinic and clinic. Biomimetic PLLA membrane was fabricated layer by layer according to the structure of human extracellular matrix. Microstructure, tensile strength, and suture retention strength were fully assessed. Before the clinical application, the safety and toxicology test of the biomimetic PLLA membrane was performed in vitro and in experimental animals. The patients underwent urethroplasty used dorsal onlay or lateral onlay technique. Then, they were followed up for 1 month, 3 months, 6 months, and then annually after the surgery. The mechanical experiments showed well property for application. Biomimetic PLLA membrane was safe according to the in vitro and animal studies. Then, a total of 25 patients (mean age 48.96 years) were included in the study from September 2016 to December 2018. After a mean follow‐up of 33.56 months, 20 patients successfully treated with biomimetic PLLA membrane. Five patients (2 bulbar and 3 penile) suffered postoperational urethral stricture recurrence. None of infection or urinary fistula or any other adverse events related to the use of biomimetic PLLA membrane were observed during the follow‐up period for all patients. The preliminary result confirmed the feasibility and efficacy of the biomimetic PLLA membrane as a novel material for anterior urethral repair. The long‐term effects with more patients should be investigated in further studies.
Smart process development: Application of machine‐learning and integrated process modeling for inclusion body purification processes
Authors: Walther Cornelia , Voigtmann Martin , Bruna Elena , Abusnina Ali , Tscheließnig Anne‐Luise , Allmer Michael , Schuchnigg Hermann , Brocard Cécile , Föttinger‐Vacha Alexandra , Klima Georg 
Published: March 2022

AbstractThe development of a biopharmaceutical production process usually occurs sequentially, and tedious optimization of each individual unit operation is very time‐consuming. Here, the conditions established as optimal for one‐step serve as input for the following step. Yet, this strategy does not consider potential interactions between a priori distant process steps and therefore cannot guarantee for optimal overall process performance. To overcome these limitations, we established a smart approach to develop and utilize integrated process models using machine learning techniques and genetic algorithms. We evaluated the application of the data‐driven models to explore potential efficiency increases and compared them to a conventional development approach for one of our development products. First, we developed a data‐driven integrated process model using gradient boosting machines and Gaussian processes as machine learning techniques and a genetic algorithm as recommendation engine for two downstream unit operations, namely solubilization and refolding. Through projection of the results into our large‐scale facility, we predicted a twofold increase in productivity. Second, we extended the model to a three‐step model by including the capture chromatography. Here, depending on the selected baseline‐process chosen for comparison, we obtained between 50% and 100% increase in productivity. These data show the successful application of machine learning techniques and optimization algorithms for downstream process development. Finally, our results highlight the importance of considering integrated process models for the whole process chain, including all unit operations.
In Situ Growth of Ultrathin NiO Nanosheet‐Arrays on MOF‐Derived Porous Co3O4 Scaffolds as High‐Performance Cathode for Asymmetric Supercapacitors
Authors: Zhou Chenming , Cao Xiaoman , Sun Zhijia , Yingwei  , Zhang Qingguo 
Published: March 2022

AbstractThe ever‐increasing market for portable and wearable electronic devices creates a demand for high‐efficiency electrochemical energy storage devices with excellent flexibility. Herein, MOF‐derived porous Co3O4 scaffolds as the core, ultrathin NiO nanosheet‐arrays as the shell, well‐aligned core‐shell structured Co3O4@NiO were constructed on carbon cloth (CC/Co3O4@NiO) via facile chemical bath methods. Composition, morphological structure, and electrochemical performance of the hybrid nanomaterials were analyzed in detail. Benefiting from the MOF‐derived porous Co3O4 core, the NiO shell with large specific surface area, and close conductive linkages between the core and shell, CC/Co3O4@NiO presents an outstanding areal capacitance of 3015.1 mF cm−2 (1206 F g−1) at 5 mA cm−2 and an exceptional rate performance. Additionally, the flexible SASC device assembled with the CC/Co3O4@NiO cathode possesses an ultra‐high volumetric energy density of 3.11 mWh cm−3 at a volumetric power density of 116 mW cm−3 with a satisfactory cycling stability (90.1 % of after 10000 cycles). These values are superior to the great majority of the state‐of‐the‐art flexible electrochemical capacitors. Thereby, the core‐shell structured CC/Co3O4@NiO is a promising candidate material for energy storage devices, and this work can provide a reference for the structural design and constructing of electrode materials.