bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measured and perceived effects of audit and feedback on nursing performance: A mixed methods systematic review
Authors: Dufour Emilie , Bolduc Jolianne , Duhoux Arnaud 
Published: November 2022

Abstract
Background: The use of audit and feedback in health care has been shown to have generally positive effects with medical teams, but little is known about its effects on nursing care. The purpose of this systematic review was to examine the evidence of measured and perceived effects of such interventions on nursing performance.
Methods: We used a mixed-methods systematic review design with thematic and narrative synthesis. Studies reporting quantitative and qualitative data on the effects of feedback interventions specific to nursing care were considered for inclusion. Studies were appraised for quality using the Mixed Methods Appraisal Tool. Quantitative and qualitative data were summarized in narrative and tabular form and were synthetized using the Joanna Briggs Institute segregated methodologies approach.
Results: Thirty-one studies published between 1995 and 2021 were included. Thirteen quantitative studies provided evidence on measured effects and 18 qualitative studies provided evidence on perceived effects. The quantitative studies, the majority of which had low to moderate methodological quality, reported highly variable effects of audit and feedback. The characteristics of most of the audit and feedback interventions were poorly aligned with the recommendations developed by the experts and were not theoretically supported. Overall, the qualitative data demonstrated that nurses perceived several negative aspects in the way audit and feedback interventions were conducted, while recognizing the relevance of secondary use of the data to support improved care.
Conclusions: Considering the practical benefits of using this type of intervention, we see in these results an important opportunity for action to improve the design and implementation of audit and feedback with nurses.
Registration: PROSPERO CRD42018104973
Correlation of Left Atrial Strain with Invasively Measured Left Ventricular End-Diastolic Pressure; determining LA strain cut-off value
Authors: Toufan Mehrnoush , Khezerlouy-aghdam Naser , Pakdel Sanaz , Separham Ahmad , Aslanabdi Naser , Sadeghi Mohamadreza Taban , Shahverdi Morad , Sakha Hanieh , Mashyekhi Sina , Mousavi Sanaz 
Published: November 2022

Abstract
Purpose
Left atrium (LA) longitudinal strain with speckle tracking has been proposed as a non-invasive method for the assessment of left ventricular filling pressure and diastolic dysfunction. This study aimed to investigate left atrial strain (LAS) compared to invasively measured left ventricular filling pressure.
Methods
All Patients candidates for coronary angiography were consecutively recruited. Longitudinal LA strain measured by Transthoracic echocardiography. Left ventricular end-diastolic pressure (LVEDP) pressure was invasively measured. Current echocardiographic modalities for diastolic function evaluated.
Results
A total of 125 people were included. 45 patients had preserved ejection fraction (EF ≥ 50%) and 85 patients had reduced EF (EF < 50%) and compared two groups. LVEDP was significantly higher in reduced EF compared to preserved EF (P-value<0.001). LA-reservoir and LA-booster strains were significantly lower in patients with reduced EF compared to preserved EF (P-value=0.008, mean Reservoir=16.4%±6.4, mean Reservoir=19.5%±5.6, respectively) and (P-value=0.009, mean Booster =9.09%±4.0, mean Booster =11. 9%±4.3, respectively). LA 4ch-reservoir<14.4%, and LA 2ch-reservoir<14.1% was related to LVEDP≥20 mmHg (sensitivity 63.5% and specificity 75%) (sensitivity 77.9% and specificity of 60%) respectively.
conclusion
LAS is significantly lower in patients with elevated LVEDP (≥ 20mmHg). LAS is significantly lower in patients with reduced EF (< 50%). Both LA-reservoir and LA-booster had a significant relation to predicting LVFP but LA-reservoir is more accurate at both 4-chamber and 2-chamber views. The amount of mean LA-reservoir LAS less than 12.4% and the 4 Ch-reservoir LAS less than 14.4% are associated with LVEDP≥20mmHg.

Keywords: left atrium, strain imaging echocardiography, ventricular end-diastolic pressure
A Quality Optimization Framework Combining Physics and Machine Learning Models: Case Study in a Friction Stir Welding Process
Authors: Kim Yongmin , Lee Seung-Joon , Kang Jihoon 
Published: November 2022

Abstract
In modern manufacturing, Artificial Intelligence (AI) and several data analysis techniques are frequently used and developed in various fields. These quantitative approaches, however, are somewhat focused on the assumption that sensor data properly expresses the physical phenomenon. Another issue is that the data can be obtained through experiments, but due to the constraints of time and cost of experiments, obtaining a large amount of data that may be able to fully explain diverse natural occurrences is impossible. In the present study, we propose a hybrid method that combines scientific knowledge and machine learning methods via an optimization framework containing Lagrange multiplier concept. Experiments with real manufacturing data from the Friction Stir Welding (FSW) process demonstrate the scientific consistency and effectiveness of the proposed idea.
Cost efficiency of Tunisian water Utility: Heteroskedastic Stochastic Frontier Approach
Authors: Amor Tawfik Ben , Mellah Thouraya 
Published: November 2022

Abstract

We examine the operating cost inefficiencies and economies of scale of Tunisian drinking water utilities. Different stochastic models that incorporate heterogeneity have been investigated. We have examined the stochastic frontier model and the fixed effects model. The results show that these models produce different results. Therefore we estimate a specific fixed-effects model where the inefficiency term remains in the model and the fixed effect is intended only to capture the firm-specific heterogeneity. This model performs better results and it allows differentiating between non-heterogeneity and inefficiency. The results indicate that significant cost inefficiencies are present in the utilities and the economies of scale are found in small-sized utilities, while large utilities exhibit diseconomies of scale. Jel Classification : C16; C23; D24; L95, L51.
WITHDRAWN: Integrative single-cell ATAC-seq and RNA-seq analysis of the fusion of mammalian upper lip and primary palate
Authors: Cai Sini , yin ningbei 
Published: November 2022

Abstract

Background:Fusion of upper lip and primary palate requires precisely coordination of transcription, a process executed from embryonic days 10.5 to 12.5 and across multiple cell types. The cellular heterogeneity and temporally-sensitive fate decisions associated make it extremely difficult to elucidate the changes of gene regulatory network throughout the fusion of upper lip and primary palate.Methods:Here we applied single-cell ATAC sequencing (scATAC-seq) and single-cell RNA sequencing (scRNA-seq) to lambdoidal junction tissue (formed by the maxillary, the lateral nasal and the medial nasal) cells from embryonic days 10.5, 11.5 and 12.5 C57BL/6J mouse embryos.Results:We identified distinct heterogeneous subgroups of three major cell types involved in the fusion of upper lip and primary palate：mesenchyme cells, ectoderm cells and endothelial cells. We inferred the differentiation trajectory of subsets of major cell types and characterized a wealth of switch genes along the pseudo-time. We described the transcriptional regulators of each cell subgroups and constructed a dynamical intercellular communication network throughout the fusion of upper lip and primary palate. Last, we profiled the cell-type specific chromatin accessibility of key genes and predicted upstream motifs of pivotal genes of canonical signaling pathways involved in the formation of upper lip and primary palate, and cleft lip/palate (CL/P).Conclusions:Overall, our results reveal the remarkable alterations of the transcriptome and chromatin openness during the fusion of upper lip and primary palate. Our study provides a useful resource for future investigation of facial development and clefting, and may facilitate the mechanistic discoveries of the prevalent human birth defect, CL/P.
A Data-Driven Approach for Modelling Karst Spring Discharge Using Transfer Function Noise Models
Authors: Rudolph Max Gustav , Collenteur Raoul Alexander , Kavousi Alireza , Giese Markus , Wöhling Thomas , Birk Steffen , Hartmann Andreas , Reimann Thomas 
Published: November 2022

Abstract
Karst aquifers are important sources of fresh water on a global scale. The hydrological modelling of karst spring discharge, however, still poses a challenge. In this study we apply a transfer function noise (TFN) model in combination with a bucket-type recharge model to simulate and predict karst spring discharge. The application of the noise model for the residual series has the advantage that it is more consistent with assumptions for optimization such as homoscedasticity and independence. In an earlier hydrological modeling study, named Karst Modeling Challenge (KMC; Jeannin et al (2021)), several modelling approaches were compared for the Milandre Karst System in Switzerland. This serves as a benchmark and we apply the TFN model to KMC data, subsequently comparing the results to other models. Using different data-model combinations, the most promising data-model combination is identified in a three-step least-squares calibration. To quantify uncertainty, the Bayesian approach of Markov-chain Monte Carlo (MCMC) sampling is subsequently used with uniform priors for the previously identified best data-model combination. The MCMC maximum likelihood solution is used to predict spring discharge for the evaluation period, indicating a superior performance compared to all other models in the KMC. It is found that the model gives a physically feasible representation of the system, which is supported by field measurements. While the TFN model simulated rising limbs and flood recession especially well, medium and baseflow conditions were not represented as accurately. The TFN approach poses a well-performing data-driven grey-box alternative to other approaches that should be considered in future studies.
Sofosbuvir/velpatasvir/voxilaprevir for patients with chronic hepatitis C virus infection previously treated with NS5A direct-acting antivirals: a real-world multicenter cohort in Taiwan
Authors: Liu Chen-Hua , Peng Cheng-Yuan , Liu Chun-Jen , Chen Chi-Yi , Lo Ching-Chu , Tseng Kuo-Chih , Su Pei-Yuan , Kao Wei-Yu , Tsai Ming-Chang , Tung Hung-Da , Cheng Hao-Tsai , Lee Fu-Jen , Huang Chia-Sheng , Huang Ke-Jhang , Shih Yu-Lueng , Yang Sheng-Shun , Wu Jo-Hsuan , Lai Hsueh-Chou , Fang Yu-Jen , Chen Po-Yueh , Hwang Jow-Jyh , Tseng Chi-Wei , Su Wei-Wen , Chang Chun-Chao , Lee Pei-Lun , Chen Jyh-Jou , Chang Chi-Yang , Hsieh Tsai‐Yuan , Chang Chung-Hsin , Huang Yi-Jie , Kao Jia-Horng 
Published: November 2022

Abstract
Background
Real-world data are scarce about the effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) for retreating East Asian patients with hepatitis C virus (HCV) infection who previously received NS5A direct-acting antivirals (DAAs). We conducted a multicenter study to assess the performance of SOF/VEL/VOX in patients who were not responsive to prior NS5A inhibitors in Taiwan.
Methods
Between September 2021 and May 2022, 107 patients who failed NS5A inhibitor-containing DAAs with SOF/VEL/VOX salvage therapy for 12 weeks were included at 16 academic centers. The sustained virologic response at off-treatment week 12 (SVR12) was assessed in the evaluable (EP) and per-protocol (PP) populations. The safety profiles were also reported.
Results
All patients completed 12 weeks of treatment and achieved an end-of-treatment virologic response. The SVR12 rates were 97.2% (95% confidence interval (CI): 92.1%-99.0%) and 100% (95% CI: 96.4%-100%) in EP and PP populations. Three (2.8%) patients were lost to off-treatment follow-up and did not meet SVR12 in the EP population. No baseline factors predicted SVR12. Two (1.9%) not-fatal serious adverse events (AE) occurred, but unrelated to SOF/VEL/VOX. Sixteen (15.0%) had grade 2 total bilirubin elevation, and three (2.8%) had grade 2 alanine transaminase (ALT) elevation. Thirteen (81.3%) of the 16 patients with grade 2 total bilirubin elevation had unconjugated hyperbilirubinemia. The estimated glomerular filtration rates (eGFR) were comparable between baseline and SVR12, regardless of baseline renal reserve.
Conclusions
SOF/VEL/VOX is highly efficacious and well-tolerated for East Asian HCV patients previously treated with NS5A inhibitor-containing DAAs.
An intervention for family members of people with suicidal behaviours
Authors: Guillén Verónica , Fonseca-Baeza Sara , Pérez Sandra , García-Alandete Joaquín , Grau Antoni , Marco José Heliodoro 
Published: November 2022

Abstract
Background: Suicide is a serious health problem, affecting not only the persons who experience it, but also their family members. Although there are few empirically supported interventions to help family members. The programme for relatives of people with Borderline personality disorder and dysregulation that has received the most empirical support is Family Connections. This is a cross-disciplinary skills training programme and contains 12 two-hour sessions held once a week. The specific objectives of the present study were: a) to adapt Family Connections program for relatives of patients with suicidal behaviour and test the efficacy of the intervention for relativesin a pilot study; b) to analyze the feasibility and acceptance of the intervention in the relatives; c) to analyze whether the changes produced in the psychological variables in the relatives after the intervention are related to changes in the psychological variables of the patients.
Method: The study sample contained 10 relatives and nine patients. The relatives were assessed before and after the intervention. The evaluation protocol consisted of the BAS, DASS-21, FES, scale of expectations and opinions about the treatment, and a critical incidents log, as well as a focus group. Regarding the data analysis, Student's t-test for related samples was conducted to examine whether there were differences between before and after the intervention, and Cohen's d was calculated as an effect size measure.
Results: Improvements were observed in most of the constructs assessed in the relatives, such as burden, concern, guilt, and depression. The relatives’ level of acceptance and satisfaction with the programme was high. In addition, patients decreased their suicidal behaviour, self-harm, visits to the emergency room, or number of verbal or physical arguments.
Conclusions: The results show the usefulness of the intervention in relatives of people with suicidal behaviour and also confirm its good acceptance by family members. Its efficacy is confirmed, also in patients. This is a population that, has few empirically validated interventions, and none that also analyse the effect of the intervention on patients. Therefore, it is possible to argue that this is a good programme to prevent suicidal behaviour in the family environment.
Trial registration: ClinicalTrials.gov ID: NCT05157607. Registered 15 December 2021. https://clinicaltrials.gov/ct2/show/NCT05157607?recrs=ab&cntry=ES&draw=2&rank=8
Fourth ventricle stent placement for treatment of type I Chiari malformation in children
Authors: Sun Peng , Zhou Mading , Liu Yutong , Du Jianxin , Zeng Gao 
Published: November 2022

Abstract
Introduction: Type I Chiari malformation (CM-I) is a common congenital malformation, often accompanied by syringomyelia. Obstruction of CSF circulation in the foramen magnum is the reason for the formation of the syringomyelia. A fourth ventricle stent (FVS) could ensure the CSF flow from the fourth ventricle, which might represent an effective approach to achieve syringomyelia relief.
Methods: We have reviewed four cases of CM-I children who received FVS implantation from November 2021 to July 2022. Each of the patients underwent FMD. The ventricular catheter of an Ommaya reservoir (Medtronic, Inc.) was used as a stent. Duraplasty was performed with autologous fascia. Cervical MRI rechecks were routinely done three months later, and the clinical symptoms were followed up.
Results: Four children received FVS, including one boy and three girls, aged from 12 months to 10 years, with a mean age of 6.8 years. No major complication occurred. The syringomyelia or hydrocephalus in each patient were all attenuated, as observed on the reexamination MRI images. During the follow-up time with a mean of 10.8 months, no patient had new symptoms.
Conclusion: FVS is an effective and safe method for operation of CM-1 in children. The indications of FVS include redo-FMD, with obstructive hydrocephalus and difficulties to ensure post-FMD CSF circulation patency at the foramen magnum.
Shearer Reliability Prediction Using Support Vector Machine Based on Chaotic Particle Swarm Optimization Algorithm
Authors: Xu Zhipeng , Zhang Xing 
Published: November 2022

Abstract
Shearer reliability is considered as one of the most important indexes in longwall mining production. However, the traditional reliability methods are based on the specific distribution of the failure parameters, which are incongruent in the actual practice. Therefore, a novle shearer reliability prediction method based on support vector machine (SVM) with chaotic particle swarm optimization (CPSO) is proposed. It combines the advantages of the high accuracy of SVM and the fast convergence of CPSO, where the chaos idea is introduced to particle swarm optimization for the particle initialization, inertia weight coefficient optimizing and premature convergence treatment. Then this CPSO is used to select and optimize the important parameters of SVM. Ultimately, the optimized parameters are used to obtain a superior CPSO-SVM method for reliability prediction. To show the effectiveness of the proposed method, two numerical comparisons are designed respectively using the literature data and the actual shearer data from the coal mine enterprise. The research results reveal the prediction accuracy and validity of the proposed method.
Correlation of neurological clinical and brain computed tomography findings of stroke patients – a multicenter study from a low-income setting
Authors: Vincent Mboizi , Sereke Senai Goitom , Nassanga Rita , Robert Mukisa , Ameda Faith 
Published: November 2022

Abstract
Background: In developing countries like Uganda, the burden of stroke is growing and causing significant morbidity and disability with high mortality rates. Neuroimaging is required to differentiate ischemic stroke from an intracerebral hemorrhage, as well as to diagnose entities other than stroke. Therefore, understanding the clinico-demographic features and brain Computed Tomography (CT) findings of stroke as well as their correlation is of utmost value in stroke management. Hence, this study sought to determine the clinical and brain CT scan findings of stroke patients attending selected centers in Kampala. Mention ASPECTS briefly
Methods: This was a cross-sectional study of clinically suspected stroke patients at three selected hospitals in Kampala, Uganda. All brain CT scans of patients with suspected stroke were evaluated and The Alberta stroke programme early CT score (ASPECTS) a 10-point quantitative topographic CT scan score used for middle cerebral artery (MCA) stroke patients. Data on the clinical-demographic and cranial CT findings were collected, and entered into REDCap software. Univariate analysis was used to describe the clinico-demographic and cranial CT features of stroke and summarized them as percentages. Further analysis was done at bivariate and multivariate levels to determine the adjusted odds ratios as a measure of association with a 95% confidence interval.
Results: Of the 270 study participants,141(52.2%) were male. 162(60%) had CT findings of stroke, and 90(33.3%) had normal cranial CT findings. While 18(6.7%) had other CT findings like a tumor, dural hemorrhage, epidermoid cyst, and others. The ischemic stroke, hemorrhagic stroke, and subarachnoid hemorrhage accounted for 124(45.9%), 34(12.6%), and 4(1.5%) respectively. Limb weakness (55.2%), headache (41.1%), and loss of consciousness (39.3%) were associated with stroke findings on CT. Among the acute ischemic strokes, 30(73.2%) had a worse (0-7) ASPECT score. Those aged ≥65 years were associated with a worse ASPECTS [AOR: 22.01, (95%CI:1.58-306.09) p-value =0.021].
Conclusion: Currently, non-contrasted brain CT is the first line imaging modality for diagnosis, differentiation of the stroke types, patient management, treatment, and timely referral to a stroke center. The clinical diagnosis of stroke is inadequate to exclude other stroke mimics. Hypertension and advanced age are the most prevailing risk factors attributed to both ischemic and hemorrhagic stroke and patients over 65 years were associated with a worse ASPECT score.
Machine learning-guided discovery of ionic polymer electrolytes for lithium metal batteries
Authors: Li Kai , Wang Jifeng , Song Yuanyuan , Wang Ying 
Published: November 2022

Abstract
Development of ionic polymer electrolytes (IPEs) without flammable organics is a critical strategy to enable safe and high-energy lithium metal batteries (LMBs). As critical components in IPEs, ionic liquids (ILs) with high ionic conductivity and wide electrochemical window are promising candidates to enable LMBs. Here, we describe a fast and robust machine learning workflow embedded with quantum chemistry calculation and graph convolutional neural network to discover promising ILs for IPEs. By selecting subsets of the recommended ILs, combining with a rigid-rod polyelectrolyte and a predetermined lithium salt, we develop a class of large area and mechanically strong IPE membranes with thickness ~ 50 μm. The symmetric cells exhibit stable cycling performance at 1 mA cm-1 (0.5 mAh cm-2) up to 800 h at room temperature (RT) and excellent reversibility at 6 mA cm-2 (3 mAh cm-2) at 80 °C. With LiFePO4 loading ~ 10.3 mg cm-2, the full cells deliver outstanding capacity retention for > 350 cycles (> 96% with 0.5 C at RT; > 80% with 2 C at 50 °C), fast charge/discharge capability (146 mAh g-1 with 5 C at 80 °C) and ultrahigh coulombic efficiency (> 99.92%). This performance is rarely reported by any single-layer polymer electrolytes without any organic plasticizers/oligomers for LMBs.