bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viewpoint: Do not resurrect the two‐stage procedure
Authors: Senn Stephen 
Published: July 2022

AbstractIn 1989, Peter Freeman published a paper that challenged a commonly accepted approach for analyzing cross‐over trials, the so‐called two‐stage procedure. Freeman himself recommended using the Bayesian approach of Andy Grieve. The flaws Freeman exposed were serious and led many statisticians to conclude that the procedure was unacceptable. Unfortunately, more than 30 years later, one still encounters its use. This note explains, using a simple simulation, why the two‐stage procedure is, indeed, as Freeman showed unacceptable and should not be used.
Do statisticians count? A prior and posterior viewpoint
Authors: Jones Margaret , Hodgson Gemma 
Published: July 2022

AbstractIn this article we look back over the last few decades and consider the progress made against the barriers that Andy Grieve has identified that may be holding statisticians back. We highlight some examples from his career where he leads the way in showing how we may overcome obstacles to enable statisticians to ‘count’ and assess whether anything has now changed for pharmaceutical statisticians.
Protective effect of Rhein against vancomycin‐induced nephrotoxicity through regulating renal transporters and Nrf2 pathway
Authors: Zhu Yanna , Jin Huan , Huo Xiaokui , Meng Qiang , Wang Changyuan , Sun Pengyuan , Ma Xiaodong , Sun Huijun , Dong Deshi , Wu Jingjing , Liu Kexin 
Published: July 2022

AbstractVancomycin (VCM)'s nephrotoxicity limits its application and therapeutic efficiency. The aim of this study was to determine the protective effect of rhein against VCM‐induced nephrotoxicity (VIN). VIN models were established in rats and NRK‐52E cells. Rhein up‐regulated the expressions of renal organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance‐associated protein 2 (Mrp2), mammal multidrug and toxin extrusion proteins 1 (Mate 1) and P‐glycoprotein (P‐gp) to facilitate the efflux of plasma creatinine, blood urea nitrogen (BUN), and plasma indoxyl sulfate. Rhein increased the expression of nuclear factor erythroid 2‐related factor 2 (Nrf2) to regulate the expression of Mrp2, P‐gp, and Mate 1. The increased level of superoxide dismutase (SOD), decreased level of malondialdehyde (MDA) and reduced number of apoptosis cells were observed after treatment of rhein. Rhein decreased the number of apoptosis cells as well as increased the expression of B‐cell lymphoma‐2 (Bcl‐2) and decreased expressions of Bcl‐2‐like protein 4 (Bax). ML385, as a typical inhibitor of Nrf2, reversed the protective effects of rhein in cells. Rhein oriented itself in the site of Keap1, inhibiting the Keap1–Nrf2 interaction. Rhein ameliorated VIN mainly through regulating the expressions of renal transporters and acting on Nrf2 pathway.
A voluminous tumour of the tracheal bifurcation
Authors: Bouanzoul Mohammed Amine 
Published: July 2022

AbstractThe tracheal bifurcation is the point at which the trachea splits into the left and right main stem bronchus conducting to the lungs. Primary tumours of the tracheal bifurcation are rare. We report images of an adenoid cystic carcinoma of the tracheal bifurcation diagnosed accidentally following recurrent episodes of haemoptysis
Evaluation of NKp46 expression and cytokine production of decidual NK cells in women with recurrent pregnancy loss
Authors: Yamamoto Mayu , Fukui Atsushi , Mai Chuxian , Saeki Shinichiro , Takayama Ryu , Wakimoto Yu , Yamaya Ayano , Kwak‐Kim Joanne , Shibahara Hiroaki 
Published: July 2022

AbstractPurposeNKp46, a receptor on NK cells, is involved in cytotoxicity and cytokine production. The authors aimed to evaluate the effect of NKp46 on decidual NK (dNK) cells during pregnancy and whether it can be a marker for immunological abnormalities in women with recurrent pregnancy loss (RPL).MethodsFlow‐cytometric analysis was made to assess NKp46 expression and intracellular cytokine production of dNK cells. The proportion of NKp46+ dNK cells was analyzed among RPL patients who aborted karyotypically normal pregnancies and those who either aborted karyotypically abnormal pregnancies or without genetic studies, and controls who were going through the induced abortion.ResultsThe %NKp46+ and %NKp46bright dNK cells were significantly lower in the RPL women who aborted karyotypically normal pregnancies than in the control group. The %NKp46bright dNK cells were significantly correlated with the NK1/NK2 ratio of dNK cells. The %NKp46+ dNK cell cutoff for RPL with immunological abnormalities was determined by the ROC curve analysis. In women with the low %NKp46+ dNK, NK1/NK2 ratios were significantly higher than those with the high.ConclusionRPL patients with an immunological abnormality have decreased NKp46 expression and NK1 shift in dNK cells. NKp46 expression could be a marker for RPL of immunological abnormalities.
A new stationary phase based on porous graphene for capillary gas chromatography
Authors: Huang Yanni , Chen Jia , Fu Gafang , Zhang Chi , Qiu Hongdeng 
Published: July 2022

AbstractThis work reported the preparation and evaluation of a 2D porous graphene as the stationary phase for gas chromatography with high‐resolution performance from non‐polar to polar structural isomers. As a result, the dynamically coated porous graphene capillary column has a film thickness of about 16 μm. After aging treatment at different temperatures, the porous graphene capillary column exhibited high thermal stability up to 300°C. In addition, the porous graphene capillary column has good column repeatability and reproducibility. The retention time RSDs are 2.61–3.90% (n = 3) during the days and 4.58–4.78% (n = 3) column‐to‐column. This work demonstrates the advantageous separation performance of a good potential for the porous graphene as a new stationary phase for gas chromatography analysis.
Hydrophobic deep eutectic solvent‐based microextraction method for the simultaneous extraction of two benzodiazepines from saliva samples before determination by 96‐well microplates‐based spectrophotometer with the aid of chemometrics
Authors: Heidari Hassan , Sadi Sevda 
Published: July 2022

AbstractIn this study, a 96‐well microplates‐based spectrophotometer with the aid of the partial least squares (PLS) approach was used for the simultaneous determination of more common benzodiazepines, clonazepam, and nitrazepam, in human saliva samples. For this purpose, a hydrophobic deep eutectic solvent (DES) based on choline chloride and 1‐phenylethanol in the mole ratio of 1:4 was prepared and utilized in the ultrasound‐assisted emulsification‐microextraction (USAEME) method followed by back‐extraction to retrieve the drugs from the DES phase to 200 μL of 0.1 M NaOH solution. Central composite design (CCD) in combination with the desirability function was used for multi‐response optimization of different parameters and the optimum values were found to be: pH 2.06; DES volume, 247.1 μL; NaCl, 1.55% (w/v); sonication time, 5.33 min. The DES‐based USAEME method showed wide linear ranges of 0.1–6 and 0.2‐8 μg/mL and good limits of detection of 0.02 and 0.05 μg/mL for clonazepam and nitrazepam, respectively. Furthermore, the method was successfully used for determining the drugs in human saliva samples.
Effects of Nano‐Titanium Dioxide andMentha piperitaEssential Oil on Physicochemical, Mechanical, and Optical Properties of Cassava Starch Film
Authors: Noorian Simin , Mohammadi Nafchi Abdorreza , Bolandi Marzieh , Jokar Maryam 
Published: July 2022

AbstractThe objective of this study is to investigate the synergistic effects of nano titanium dioxide (TiO2‐N) andMentha piperitaessential oil (MEO) on cassava starch film characteristics. Cassava starch films with TiO2‐N (1%, 3%, and 5% of dried starch) and MEO (1%, 2%, and 3% of dried starch) are prepared by a casting method. Physicochemical, mechanical, barrier, and optical properties of the films are evaluated. The moisture content, solubility, water absorption capacity, water vapor permeability, and transparency of films significantly decrease with the incorporation of TiO2‐N and MEO. The color of bionanocomposite films is darker, yellower, and redder than that of the control film. The highest tensile strength (23.39 MPa), highest Young's modulus (39.51 MPa), and lowest elongation (6.63%) are observed in the film containing 5% TiO2‐N and 1% MEO. The incorporation of TiO2‐N and MEO reduces the percentage of UV transmitted from films. In summary, the results show that the combination of TiO2‐N and MEO improves the starch film characteristics, and these bionanocomposite films could be used for food packaging or coating.
Genetic and molecular analysis reveals that two major loci and their interaction confer clubroot resistance in canola introgressed from rutabaga
Authors: Wang Z. , Megha S. , Kebede B. , Kav N. N. V. , Rahman H. 
Published: July 2022

AbstractClubroot disease caused by Plasmodiophora brassicae is one of the serious threats to canola (Brassica napus L. subsp. napus) production. The evolution of new pathotypes rendering available resistances ineffective compel the introgression of new resistance into canola and extend our understanding of the genetic and molecular basis of the resistance. In this paper, we report the genetic and molecular basis of clubroot resistance in canola, introgressed from a rutabaga (B. napus L. subsp. rapifera Metzg. ‘Polycross’), by using a doubled‐haploid (DH) mapping population. Whole‐genome resequencing (WGRS)‐based bulked segregant analysis followed by genetic mapping and expression analysis of the genes in resistant and susceptible DH lines at 7 and 14 d after inoculation were carried out. Following this approach, two major quantitative trait loci (QTL) located at 14.41–15.44 Mb of A03 and at 9.96–11.09 Mb of A08 chromosomes and their interaction was observed to confer resistance to pathotypes 3H, 3A, and 3D. Analysis of the genes from the two QTL regions suggested that decreased expression of sugar transporter genes (BnaA03g29290D and BnaA03g29310D) may play an important role in resistance conferred by the A03 QTL, while increased expression of the toll/interleukin‐1 receptor (TIR)–nucleotide binding (NB)–leucine rich repeat (LRR) (TNL) genes (BnaA08g10100D, BnaA08g09220D, and BnaA08g10540D) could be the major determinant of the resistance conferred by the A08 QTL. Single‐nucleotide polymorphism (SNP) allele‐specific polymerase chain reaction (PCR)‐based markers, which could be detected by agarose gel electrophoresis, were also developed from the two QTL regions for use in breeding including pyramiding of multiple clubroot resistance genes.
Language is Identity: Telling and Reading the Right Kinds of Stories
Authors: Przymus Steve Daniel , Heiman Daniel , Hibbs Brian 
Published: July 2022

AbstractThe field of reading instruction has long valued storytelling for literacy development, but what kinds of stories are bi/multilingual students exposed to at school? Through the cognitive phenomena of conceptual metonymy and metaphor, this article links language to identity and exposes practices that act to fracture the identities of bi/multilingual students, redefined here as active bilingual learners/users of English (ABLE). Three teacher practices are detailed for creating a school world that reflects the identities of ABLE students: (1) using content‐based story retells, (2) critically questioning the display of languages on school walls and in dual‐language books, and (3) co‐constructing stories with ABLE students and their family/community members. Examples of these practices are provided, concluding with Language is Identity Awareness (LiIA) activities and how to activate critical consciousness through translanguaging pedagogy. Opening up space for critical translanguaging pedagogy is needed to start telling, writing, and reading the right kinds of stories.
Orthotopic ureterocele with concurrent ureteral urothelial carcinoma in a dog
Authors: Kim Mu‐Young , Aerin Jeong , Traslavina Ryan P. , Yoon Hun‐Young 
Published: July 2022

AbstractA ureterocele is a rare congenital anomaly with cystic dilation of the terminal segment of the ureter entirely within the bladder (orthotopic) or associated with ectopic ureter (ectopic). Its aetiology has not been fully clarified; however, it may involve genetic or acquired factors. Urothelial carcinoma (UC) is the most common type of canine urinary tract neoplasm, among which over 90% of cases are invasive. The non‐papillary (flat) non‐infiltrating form accounts for a very small percentage of canine UCs and is considered carcinoma in situ (CIS). The neoplastic cells of CIS remain within the ureteral mucosa and do not breach the basement membrane. UCs originating from the canine ureter are extremely rare, and no report of a ureteral UC concurrently occurring with a ureterocele has been reported. A 7‐year‐old castrated male Maltese dog weighing 3.5 kg was referred with a 2‐week history of lethargy, anorexia, pollakiuria and intermittent panting. The dog underwent open surgery for removal of bladder calculi 2 years prior, and at the time of the surgery, no other urinary system abnormalities were identified. Ultrasonographic and computed tomographic scans revealed a severely enlarged right kidney and ureter with a ureterocele on the ipsilateral side. A diagnosis of an orthotopic ureterocele causing hydronephrosis and hydroureter was established. Complete nephroureterectomy and ureterocelectomy using the marsupialisation technique were performed. The postoperative histological examination of the excised tissues showed a multifocal carcinoma in situ (non‐papillary non‐infiltrating UC) in the proximal ureter and a fluid‐filled kidney with a thin rim of fibrotic renal tissue. No neoplastic changes were observed in the ureterocele tissue. Postoperatively, the dog recovered rapidly without complications except temporary urinary incontinence, and no evidence of tumour recurrence was detected by ultrasonography performed 6 months after surgery. This case report describes the first case of a dog with an orthotopic ureterocele and ureteral UC, which occurred concurrently at the ipsilateral side of the ureter. The condition was successfully managed with a nephroureterectomy and partial ureterocelectomy.
CyCLOPS: A National Integrated GNSS/InSAR Strategic Research Infrastructure for Monitoring Geohazards and Forming the Next Generation Datum of the Republic of Cyprus
Authors: Danezis Chris , Kakoullis Dimitris , Fotiou Kyriaki , Pekri Marina , Chatzinikos Miltiadis , Kotsakis Christopher , Brcic Ramon , Eineder Michael , Nikolaidis Marios , Ioannou Georgios , Christofe Andreas , Kyriakides Nicholas , Melillos George , Christoforou Michalakis , Tzouvaras Marios , Pilidou Sylvana , Themistocleous Kyriacos , Hadjimitsis Diofantos 
Published: July 2022

Abstract
The objective of this paper is to introduce CyCLOPS, a novel strategic research infrastructure unit, and present its current progress of implementation, and integration in the National geodetic, geophysical and geotechnical infrastructure of the government-controlled areas of the Republic of Cyprus. CyCLOPS is co-funded by the European Regional Development Fund and the Republic of Cyprus through the Research and Innovation Foundation under the grant agreement RIF/INFRASTRUCTURES/1216/0050. CyCLOPS is developed via the collaboration of the Cyprus University of Technology (CUT) and the German Aerospace Center (DLR), and supported by the Cyprus Geological Survey Department and the Department of Lands and Surveys. The main objective of CyCLOPS is to establish an integrated infrastructure for space-based monitoring of geohazards using the most prominent earth observation technologies (EO), such as GNSS and InSAR. Furthermore, the infrastructure will densify and form the backbone for the definition of the next generation national datum of the Republic of Cyprus. Eleven Tier-1/2 state-of-the-art GNSS CORS, precise weather stations, tiltmeters and specifically designed InSAR triangular trihedral corner reflectors will be deployed, in a collocated fashion, at selected locations throughout the government-controlled areas of Cyprus. The collocated configuration will be established and installed to be compliant with the most stringent CORS monumentation specifications, support all current GNSS constellations and SAR missions. Finally, one of CyCLOPS’ fundamental aims is to actively contribute to the on-going efforts and growing demand for more precise positioning services and high-quality modern reference frames, in conformity with the recommendations of the UN-GGIM (and its Subcommittee of Geodesy) to establish and enhance national geodetic infrastructures to support the sustainable management of geospatial information on the changing Earth.
TIPA Experiments in Other Authentic Democracies
Authors: Hill Lisa , Douglass Max , Baltutis Ravi 
Published: July 2022

AbstractIn this chapter we offer a review of trials and experiments in truth in election advertising legislation in other comparable settings in order to see what lessons might be taken from them. Analysis of legislation in other jurisdictions reveals the multiple challenges facing this type of legislation and is instructive for those considering a similar legal approach. These challenges have also enriched our own efforts to render s 113 of the Electoral Act 1985 (SA) (as well as s 297A of the Electoral Act 1992 (ACT)) more robust, operable and successful in addressing the problem of false campaign statements and improving the quality of electoral discourse. The relevant trial settings are New Zealand, the United Kingdom, Canada and the United States.
Mixed Communication Design of Phasor Data Concentrator in Distribution Network
Authors: Wu Yan , Tao Weiqing , Zhang Yingjie , Li Xueting 
Published: July 2022

AbstractPhase Data Concentrator (PDC) is an important part of Wide Area Measurement System (WAMS) and is widely used in transmission systems. WAMS technology will also be applied in smart distribution network, which has many nodes, complex architecture and various types of data transmission services, and a single communication mode cannot meet its needs. In order to solve this problem, this paper first introduces the composition of WAMS system, communication network mode, and discusses the access layer communication network mode. According to the main station, sub-station interaction process design a synchronous phase data set device that can carry out up-down communication and mix network by various means of communication. Finally, the experimental environment of Power Line Carrier (PLC) and twisted pair network communication is set up to verify.
Control Model Design for Monitoring the Trust of E-logistics Merchants
Authors: Sun Susie Y. 
Published: July 2022

AbstractIn order to improve the subjectivity bias of the traditional autocorrelation function analysis method, this paper tries to introduce the mutual correlation criterion to establish the asymptotic control model in the e-logistics trust degree control application. By pre-constructing the resource database structure model of e-logistics, we adopt the DOI mutual correlation criterion to describe the user’s trust degree evaluation of resources, and then form the user trust Simulation experiments show that the model has a good asymptotic control performance on the trust degree of e-logistics with accurate trust evaluation and high estimation accuracy. The decision making approach based on the mutual correlation criterion, in which two or more users jointly make the normalized evaluation of the mutual trust value model, can effectively improve the traditional model autocorrelation active selection bias. The new model realizes the progressive control of e-logistics trust degree based on the mutual correlation criterion, which can significantly improve the supervision of e-logistics enterprises.
Certificateless Identity Management and Authentication Scheme Based on Blockchain Technology
Authors: Han Chao , Wen Fengtong 
Published: July 2022

AbstractIdentity management and authentication in cyberspace is crucial for all forms of remote communication. The traditional authentication technology has great security risks due to its central third-party structure, such as single point of failure, malicious server attacks and so on. The emergence of blockchain technology provides a new way of thinking to solve this problem. This paper focuses on the identity management and authentication scheme based on blockchain technology. Using the decentralized, open and transparent characteristics of blockchain to make up for the shortcomings of traditional identity management and authentication mechanisms. In this paper, we analyze the BIDaaS [1] identity management and authentication scheme proposed by Jong-Hyouk and point out the obvious shortcomings of the scheme, such as suffer impersonating attack simply, virtual identities are not unique. We combine the specificity of biological characteristics to implement a unique virtual identity on the chain and improve the off-chain identity authentication process using a certificateless scheme to build a reasonable and secure identity management and authentication scheme, which realizes two-way authentication and session key agreement. The analysis shows that the scheme has a high level of safety.
The Ground-State Potential Energy Surface of F-Li2 Polymer
Authors: Wang Yue , Li Qingling , Liu Guoqing , Gong Wenhao , Yu Shijun , Liu Yu , Dong Xiaozhou , Chen Shiwen , Zhang Chengwen 
Published: July 2022

AbstractThe first three-dimensional potential energy surface (PES) for the ground-state of F-Li2 polymer by CCSD(T) method were present. Two Jacobi coordinates, R and θ and the frozen molecular equilibrium geometries were used. We mixed basis sets aug-cc-pCVQZ for the Li atom and aug-cc-pCVDZ for the F atom, with an additional (3s3p2d) set of midbond functions. The total of about 365 points were generated for the PES. Our ab initio calculations were consistent with the experimental data very well.
Research on Campus Card and Virtual Card Information System
Authors: Cheng Shuai 
Published: July 2022

AbstractCampus card system is the core business and platform of University Information System. After more than ten years of development, it covers all aspects of campus life: learning, teaching and research. This paper explains the current situation of campus card system from the perspective of card, account and billing, descripts system design and account model. Based on current system, this paper analyses the development of virtual campus card and describes a Data docking method in Information System.
An Improved Time Series Network Model Based on Multitrack Music Generation
Authors: Zhao Junchuan 
Published: July 2022

AbstractDeep learning architecture has become a cutting-edge method for automatic music generation, but there are still problems such as loss of music style and music structure. This paper presents an improved network structure of time series model based on multi-track music. A context generator is added to the traditional architecture. The context generator is responsible for generating cross-track contextual music features between tracks. The purpose is to better generate single-track and multi-track music features and tunes in time and space. A modified mapping model was further added to further modify the prediction results. Experiments show that compared with traditional methods, the proposed will partially improve the objective music evaluation index results.