bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Gender-Affirming Surgery Terminology
Authors: Makhoul Alan T. , Morrison Shane D. , Mundra Leela S. , Kaoutzanis Christodoulos , Satterwhite Thomas , Winocour Julian S. , Al Kassis Salam , Drolet Brian C. 
Published: February 2022

Background
To promote patient safety and build trust, plastic surgeons must use patient-centered language when discussing gender-affirming surgery. However, the existing terminology has not been evaluated from a patient perspective. This study sought to understand how gender-affirming surgery patients from 3 US geographic regions perceive common terminology.

Methods
An anonymous, 24-item electronic survey was distributed to gender-affirming surgery patients seen in Tennessee, Colorado, and California. After institutional review board exemption, the survey instrument was pretested and piloted with gender-affirming surgery patients. Internal consistency was assessed by computation of Cronbach α (0.87).

Results
A total of 306 participants completed the survey: 68 from a Tennessee academic center (response rate, 56%), 131 from a California private practice (response rate, 8%), and 107 from a Colorado academic center (response rate, 53%). A greater proportion of respondents felt the terms “top surgery” and “bottom surgery” were appropriate (83% and 82%, respectively) relative to “chest surgery” and “genital surgery” (41% and 30%, respectively). More respondents favored the phrase “gender-affirming surgery” than “gender-confirming surgery” (86% vs 67%). Nearly half (43%) perceived the phrase “sex reassignment surgery” as inappropriate. Most respondents (80%) preferred their surgeon ask for their pronouns.

Conclusions
Optimizing communication is an actionable way for plastic surgeons to improve the healthcare experiences of gender-affirming surgery patients. “Top surgery” and “bottom surgery” are favored terms, and “gender-affirming surgery” is the preferred name for this discipline. Language preferences should be openly discussed with each patient to ensure professional communication.
Natural Language Processing to Identify Patients with Cognitive Impairment
Authors: Hussein Khalil I , Chan Lili , Van Vleck Tielman , Beers Kelly , Mindt Monica R , Wolf Michael , Curtis Laura M. , Agarwal Parul , Wisnivesky Juan , Nadkarni Girish N. , Federman Alex 
Published: February 2022

AbstractINTRODUCTIONEarly detection of patients with cognitive impairment may facilitate care for individuals in this population. Natural language processing (NLP) is a potential approach to identifying patients with cognitive impairment from electronic health records (EHR).METHODSWe used three machine learning algorithms (logistic regression, multilayer perceptron, and random forest) using clinical terms extracted by NLP to predict cognitive impairment in a cohort of 199 patients. Cognitive impairment was defined as a mini-mental status exams (MMSE) score <24.RESULTSNLP identified 69 (35%) patients with cognitive impairment and ICD codes identified 44 (22%). Using MMSE as a reference standard, NLP sensitivity was 35%, specificity 66%, precision 41%, and NPV 61%. The random forest method had the best test parameters; sensitivity 95%, specificity 100%, precision 100%, and NPV 97%DISCUSSIONNLP can identify adults with cognitive impairment with moderate test performance that is enhanced with machine learning.
Assessing the health benefits of physical activity due to active commuting in a French energy transition scenario
Authors: Barban Pierre , de Nazelle Audrey , Chatelin Stéphane , Quirion Philippe , Jean Kévin 
Published: February 2022

ABSTRACTBackgroundEnergy transition scenarios are prospective outlooks describing combinations of changes in socio-economic systems that are compatible with climate targets. These changes could have important health co-benefits. We aimed to quantify the health benefits of physical activity caused by active transportation on all-cause mortality in the French negaWatt scenario over the 2021-2050 period.MethodsRelying on a health impact assessment framework, we quantified the health benefits of increased walking, cycling and E-biking projected in the negaWatt scenario. The negaWatt scenario assumes increases of walking and cycling volumes of +11% and +612%, respectively, over the study period.ResultsAs compared to a scenario with no volume increase, we quantified that the negaWatt scenario would prevent 9,797 annual premature deaths in 2045 and translate into a 3-month increase of life expectancy in the general population. These health gains would generate €34 billion of economic benefits from 2045 onwards,ConclusionsIncreased physical activity implied in the negaWatt transition scenario would generate substantial public health benefits, which are comparable to the gain expected by large scale health prevention interventions.
A new insight into MYC action: control of RNA polymerase II methylation and transcription termination
Authors: Scagnoli Fiorella , Palma Alessandro , Favia Annarita , Scuoppo Claudio , Illi Barbara , Nasi Sergio 
Published: February 2022

AbstractA common catastrophic event in most human cancers is deregulation of MYC, a multifunctional transcription factor that controls gene expression in partnership with MAX and drives key biological mechanisms of the cell. Restraining its activity impairs cancer cell features and prevents tumor development, as shown by Omomyc - a 90 amino acid mini-protein interfering with MYC activity. MYC regulates many aspects of transcription by RNA polymerase II (RNAPII), such as activation, pause release, and elongation. That it may have a role in transcription termination as well is suggested by our finding of an interaction between MYC and the Protein Arginine Methyltransferase 5 (PRMT5), which catalyzes symmetrical dimethylation of RNAPII at the arginine residue R1810 (R1810me2s) allowing proper termination and splicing of transcripts. Here we show that MYC overexpression strongly increases R1810me2s, while the concomitant expression of Omomyc or a MYC-specific shRNA counteracts this capacity. Omomyc impairs as well Serine 2 phosphorylation in the RNAPII carboxyterminal domain, a modification that sustains transcript elongation and is enhanced by MYC. By displacing MYC on DNA, Omomyc reshapes RNAPII distribution along genes, leading to greater occupancy of promoter and termination sites. It is unclear how this may affect expression of the variety of genes that control metabolic, biosynthetic, and other pathways and are up or down regulated upon MYC inhibition. Genes belonging to a signature of direct MYC targets are instead strongly downregulated following MYC inhibition, with a weak correlation with RNAPII occupancy at promoters. Our data point to a MYC/ PRMT5/RNAPII axis that controls termination via RNAPII dimethylation (R1810me2s) and may contribute to fine-tune the expression of genes altered by MYC overexpression in cancer cells. It remains to be seen which role this may have in tumor development and maintenance.
Reconstitution and Expression of mcy Gene Cluster in The Model Cyanobacterium Synechococcus 7942 Reveals a Roll of MC-LR in Cell Division
Authors: Zheng Yanli , Xue Chunling , Chen Hui , Jia Anqi , Zhao Liang , Zhang Junli , Zhang Lixin , Wang Qiang 
Published: February 2022

AbstractCyanobacterial blooms pose a serious threat to public health due to the presence of cyanotoxins. The most common cyanotoxins, microcystins (MCs), can cause acute poisoning at high concentrations and hepatocellular carcinoma following chronic exposure. Among all MC variants, MC-LR produced by Microcystis aeruginosa PCC 7806 is the most common toxic MC. Although the biosynthetic pathway for MC-LR has been proposed, experimental support of this pathway is lacking. In an effort to experimentally validate this pathway, we expressed the 55 kb microcystin biosynthetic gene cluster (mcy cluster) (mcyA–J) and produced MC-LR in the model cyanobacterium Synechococcus 7942. We designed and constructed the strong bidirectional promoter biPpsbA2 between mcyA and mcyD, reassembled the mcy cluster in yeast by transformation-associated recombination (TAR cloning), transformed the gene cluster into the NSII site of Synechococcus 7942, and successfully expressed MC-LR at a level of 0.006–0.018 fg cell−1 day−1. The expression of MC-LR led to abnormal cell division and the filamentation of Synechococcus 7942 cells, further analysis proved a role of MC-LR in functional assembly of the cell division protein FtsZ, by competing its GTP binding site. These results represent the first synthetic biological expression of the mcy cluster and the autotrophic production of MC-LR in a photosynthetic model organism, which lays the foundation for resolving the MC biosynthesis pathway. The suggested role of MC-LR in cell division reveals a mechanism of how blooming cyanobacteria gain a competitive edge over their non-blooming counterparts.HighlightsWe expressed the 55 kb mcy cluster and produced MC-LR in the model cyanobacterium Synechococcus 7942.This is the first realized production of MC in the model non-toxin-production cyanobacteria from CO2 by photosynthesis.Compared with the self-replicating plasmid, the recombination of the mcy cluster into the genome of Synechococcus 7942 is more suitable for the heterologous production of microcystin.MC-LR inhibits cell division by irreversibly competing the GTP binding domain of the cell division protein FtsZ.The newly discovered effect of MC-LR on cell division reveals a mechanism of how blooming cyanobacteria gain competitive edge over their non-blooming counterparts.
Managing enterprise social media to develop consumer trust
Authors: Tseng Hsiao-Ting , Shanmugam Mohana , Magalingam Pritheega , Shahbazi Shahriyar , Featherman Mauricio S. 
Published: February 2022

PurposeThis study examines the impact of social media information sharing and usage on consumer beliefs particularly in the credibility of the information provided by e-commerce vendors, and consumer trust formation.Design/methodology/approachDrawing on trust through social media usage and surface credibility, the authors have proposed a research model to investigate consumers satisfaction on food and beverage (F&B) products. Empirical support for the research model was provided by using structural equation modelling using survey data drawn from Malaysian consumers with an account with Facebook.FindingsResults indicate that consumer participation in social media communities support higher levels of consumer trust and ratings of the surface credibility of information provided by an F&B vendor, and surface credibility also helped to develop consumer trust. Trust in the vendor also exerted a positive influence on consumer satisfaction with F&B product offerings. Results suggest that F&B that provide credible and transparent information regarding their branded products, enjoy increased levels of consumer trust, leading to higher levels of consumer satisfaction with their F&B consumption experience.Originality/valueThe result of this research contributes to social commerce branch of literature and has practical implications for practitioners in the F&B industry as a means to survival strategies to embrace critical and challenging period during an endemic, particularly. As such, this study analyses the relationship between social media usage, surface credibility, trust and satisfaction for developing consumer trust while managing enterprise social media.
Productization and product structure enabling BIM implementation in construction
Authors: Mansoori Solmaz , Harkonen Janne , Haapasalo Harri 
Published: February 2022

PurposeThis study aims to facilitate consistency of information in building information modelling (BIM) and address the current BIM gaps through the perspectives of the productization concept and product structure (PS).Design/methodology/approachThe study follows a conceptual research approach in conjunction with a single case study. First, the previous studies on BIM implementation, productization and PS are reviewed. Further, a case study is used to analyse the current state of productization in the construction sector and develop a functional PS for construction.FindingsA Part-Phase-Elements Matrix is proposed as a construction-specific PS to facilitate consistency in information and to enhance BIM. The proposed matrix provides new avenues to facilitate consistent information exchange through the interconnection between conceptual PS and standard building objects library, and encourage collaborative communication between stakeholders.Originality/valueThis study explores the core of the productization concept and PS as means to facilitate consistency of information and thus address the current gaps in BIM. This as building projects progressively move towards systematic modular and prefabricated construction where the flow of reliable information about product and construction offerings becomes increasingly important.
Comparative study of the perceptions of Mexican and Colombian employees about managerial and leadership behavioural effectiveness
Authors: Ruiz Carlos Enrique , Hamlin Robert , Torres Luis Eduardo 
Published: February 2022

Purpose
The purpose of this qualitative study is to compare the perceptions of employed people in Mexico and Colombia about managerial and leadership behavioural effectiveness.

Design/methodology/approach
A qualitative multiple cross-case and cross-nation comparative analysis of findings obtained from the two past emic replication (Mexico and Colombia) studies was conducted.

Findings
The study suggests that people within Mexican and Colombian organizations perceive “managerial and leadership behavioural effectiveness” in very similar ways. The findings support those researchers whose studies indicate that culture may not, as previously thought, play a significant role in the way managers should manage and lead their subordinates.

Research limitations/implications
The authors acknowledge two main limitations related to the sample size and scope of the two compared sets of empirical source data. The number of critical incidents about perceived managerial behavioural effectiveness obtained from the two compared studies was unbalanced (318 from the Mexican study and 267 from the Colombian study). Thus, the authors suggest more indigenous replication managerial behaviour studies be carried out in both Mexico and Colombia with the objective of identifying (if possible) the existence of critical incidents that could lead to different findings. Furthermore, the authors suggest conducting replica studies focused on specific industries rather than a diverse range of organizations to test the generalizability of the findings.

Practical implications
The findings of the comparative study are relevant to those human resource development professionals in international companies with operations in Mexico and/or Colombia when preparing their executives for international assignments in these Latin American countries.

Originality/value
The comparative study attempts to generate new insights and better understanding within the context of “managerial and leadership behavioural effectiveness” research, which the authors hope will make a useful contribution to the existing small body of knowledge regarding similarities and differences in managerial practices across culturally diverse Latin American countries.
SARS CoV-2 seroprevalence and diagnostic accuracy during a COVID-19 outbreak in a major penitentiary complex in Brazil, June to July 2020
Authors: Gouvea-Reis Fernando Augusto , Soares da Silva Danniely Carolinne , Borja Lairton Souza , Dias Patrícia de Oliveira , Percio Jadher , Peterka Cassio , de Oliveira Janaína , Sodré Giselle , Feres Claudia Mendes , Dos Santos Wallace , Souza Fábio , Passarella Teixeira Ana Izabel , Cilião-Alves Daiani Cristina , Romero Gustavo Adolfo Sierra , Ferreira Noronha Elza , Croda Julio , Haddad Rodrigo , Ramalho Walter Massa , de Moraes Camile , Araújo Wildo Navegantes de 
Published: February 2022

Purpose
This study aims to estimate the overall SARS-CoV-2 seroprevalence and evaluate the accuracy of an antibody rapid test compared to a reference serological assay during a COVID-19 outbreak in a prison complex housing over 13,000 prisoners in Brasília.

Design/methodology/approach
The authors obtained a randomized, stratified representative sample of each prison unit and conducted a repeated serosurvey among prisoners between June and July 2020, using a lateral-flow immunochromatographic assay (LFIA). Samples were also retested using a chemiluminescence enzyme immunoassay (CLIA) to compare SARS-CoV-2 seroprevalence and 21-days incidence, as well as to estimate the overall infection fatality rate (IFR) and determine the diagnostic accuracy of the LFIA test.

Findings
This study identified 485 eligible individuals and enrolled 460 participants. Baseline and 21-days follow-up seroprevalence were estimated at 52.0% (95% CI 44.9–59.0) and 56.7% (95% CI 48.2–65.3) with LFIA; and 80.7% (95% CI 74.1–87.3) and 81.1% (95% CI 74.4–87.8) with CLIA, with an overall IFR of 0.02%. There were 78.2% (95% CI 66.7–89.7) symptomatic individuals among the positive cases. Sensitivity and specificity of LFIA were estimated at 43.4% and 83.3% for IgM; 46.5% and 91.5% for IgG; and 59.1% and 77.3% for combined tests.

Originality/value
The authors found high seroprevalence of anti-SARS-CoV-2 antibodies within the prison complex. The occurrence of asymptomatic infection highlights the importance of periodic mass testing in addition to case-finding of symptomatic individuals; however, the field performance of LFIA tests should be validated. This study recommends that vaccination strategies consider the inclusion of prisoners and prison staff in priority groups.
Customer-centric strategy driving innovativeness and business growth in international markets
Authors: Tuominen Sasu , Reijonen Helen , Nagy Gábor , Buratti Andrea , Laukkanen Tommi 
Published: February 2022

PurposeThe motivation for this study comes from decision making related to strategic marketing orientations in international markets. The authors examine if customer orientation and customer relationship orientation perform as two distinct constructs in driving firm innovativeness, and how together they support business growth among export firms. This study aims to suggest a customer-centric strategy for export firms that drive innovativeness and growth.Design/methodology/approachAn international corporation specialized in company information services provided a list of the contact information of Italian companies. The authors sent an email request to respond to an online survey and received 416 effective responses from firms operating in export markets. The authors propose and empirically test a model in which customer orientation, customer relationship orientation and innovativeness predict business growth. This model controls for the effects of firm size, industry and customer type (B2B vs. B2C).FindingsThe study findings suggest that customer orientation and customer relationship orientation are two distinct strategic orientations driving innovativeness. However, they do not directly affect business growth. Instead, they require the innovativeness of an exporter to materialize as business growth.Practical implicationsThe results of the study recommend business strategies focusing not only on customer needs and satisfaction but also on retaining current customers and building customer relationships in international markets. Firms can learn from international customers and develop effective customer-centric strategies to spread the acquired information into the internal decision-making as it contributes to firm innovativeness and business growth in international markets.Originality/valueThis study is one of the pioneering studies combining customer orientation and customer relationship orientation, showing their theoretical and empirical divergence. This study is also among the first which tests how the two strategic orientations together with innovativeness promote business growth among export firms. The authors add understanding of the synergistic effects both of using customer information and developing deeper relationships on firm innovativeness and performance among exporters.
Linear and non-linear ARDL estimation of financial innovation and economic growth in Ghana
Authors: Nsor-Ambala Randolph , Amewu Godfred 
Published: February 2022

PurposeThis study aimed to explore the effect of Financial Innovation (FI) on economic growth in Ghana, with a dataset spanning 1960–2019, adopting a broader conceptualization of FI as the ratio of broad money to narrow money.Design/methodology/approachThe study employs a non-linear autoregressive distributed lag (ARDL) time series econometric model to estimate data from the World Bank (1960–2019).FindingsThere is no evidence that FI significantly impacts economic growth. This could be due to the early and strict regulation of the financial technology (FIN-TECH) sector and the general inconclusiveness of the impact of financial development on economic growth.Practical implicationsPolicymakers must empirically explore the impact of early and strict regulation on the transformational impact of FI.Originality/valueThe paper is among the first to apply a broader conceptualization of FI in estimating the impact of FI on economic growth.
Stakeholder engagement, flexible proactiveness and democratic durability as CSR strategic postures to overcome periods of crisis
Authors: Gromis di Trana Melchior , Fiandrino Simona , Yahiaoui Dorra 
Published: February 2022

PurposeThe aim of this study is twofold. First, the research aims to identify Integrated Thinking (IT) stages of development. Second, the research aims to investigate how IT has reacted to the COVID-19 pandemic by accelerating integrated corporate social responsibility (CSR) practises.Design/methodology/approachThe study employs a case study on an Italian multi-utility company, Iren Group. The research method uses triangulated data collected from semi-structured interviews and archival materials and it analyses data with a top-down and bottom-up coding procedure. This allows us to inductively develop a model of IT stages of development and CSR strategic postures as response patterns to the COVID-19 pandemic.FindingsThe research identifies the developmental paths of IT initiation, IT reactiveness and IT implementation responding to changes and challenges in times of crisis. Furthermore, the research provides stimuli for recovery to overcome periods of crisis through three main CSR strategic postures: stakeholder engagement, flexible proactiveness and democratic durability.Practical implicationsThe research suggests that managers can adopt stakeholder engagement, flexible proactiveness and democratic durability as CSR strategic postures in order to integrate CSR practises into the company's DNA and overcome periods of crisis.Originality/valueThis is among the first studies that analyses how IT acts during a crisis in the multi-utility sector. There are three main stages of development, i.e. IT initiation, IT reactiveness and IT implementation, which are characterised by stakeholder engagement, flexible proactiveness and democratic durability.