bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape, National Identity and the Medieval Past in England, c.1840–1914
Authors: Readman Paul 
Published: August 2022

Abstract
This article re-examines the place of the Middle Ages in nineteenth- and early twentieth-century English culture. In doing so, it presents an argument about the interrelationship of landscape, history and English national identity. Emphasising the importance of the medieval past to mainstream constructions of Englishness, the article shows how this importance largely derived from the felt presence of the Middle Ages in the physical environment, in the landscape of England. Their history congealed in the fields, forests, hills, towns and villages of the present day, the Middle Ages were readily accessible through imaginative agency and possessed of vital contemporary meaning. Embodied experience of landscape offered Victorians and Edwardians compelling evidence of the long continuities of English national history, from Anglo-Saxon times onwards. In an increasingly democratic context, the medieval presence in the landscape was evidence of the continuity not only of the institutions of the realm, but of the English people themselves. Until at least the First World War, and perhaps beyond, the tangible heritage of the Middle Ages in the English landscape served as an important source of reassurance of the nation’s endurance and progress, amid the transformations of modernity.
Anterior open bite self-correction after cessation of non-nutritive sucking habits: a systematic review
Authors: Adriano Letícia Zacchi , Derech Carla D’Agostini , Massignan Carla , Flores-Mir Carlos , Porporatti André Luís , Canto Graziela De Luca , Bolan Michele 
Published: August 2022

Summary

Background
Non-nutritive sucking habits likely may cause occlusal changes such as anterior open bite (AOB) if they persist over extended time.

Objectives
To assess if there is self-correction of AOB after cessation of non-nutritive sucking habits in children older than 4 years old, through a systematic review.

Search methods
Data sources included PubMed, Scopus, Web of Science and Latin American and Caribbean Health Sciences (LILACS) databases, gray literature as Google Scholar, the database System for Information on Gray Literature in Europe (OpenGrey) and ProQuest Dissertations and Theses Database, also hand searches of the included studies references.

Selection criteria
Studies assessing occlusal changes in children aged 4–12 years with AOB traits and non-nutritive sucking habits after the discontinuation of the habit were included.

Data collection and analysis
Two authors independently assessed eligibility and extracted data. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale and the Joanna Briggs Critical Appraisal Checklist for quasi-experimental studies. The confidence in cumulative evidence was assessed using the GRADE criteria.

Results
Over 3100 studies, only 5 met the inclusion criteria. There is often self-correction of AOB after discontinuing the non-nutritive sucking habit, even in cases older than 4 years old. The improvement ranged between 50 and 100%. The overall quality of evidence was very low.

Conclusions
AOB self-correction after discontinuing a non-nutritive sucking habit is possible, even after 4 years old, although with very low certainty in the body of evidence. It is not clear after what age the removal from the habit is unlikely to facilitate AOB self-correction.

Registration and conflict of interest
International Prospective Register of Systematic Reviews code: CRD42016052171. There was no conflicting interest from the review authors.
In-hospital mortality and major complications related to radiofrequency catheter ablations of over 10 000 supraventricular arrhythmias from 2005 to 2020: individualized case analysis of multicentric administrative data
Authors: Doldi Florian , Geßler Nele , Anwar Omar , Kahle Ann-Kathrin , Scherschel Katharina , Rath Benjamin , Köbe Julia , Lange Philipp Sebastian , Frommeyer Gerrit , Metzner Andreas , Meyer Christian , Willems Stephan , Kuck Karl-Heinz , Eckardt Lars 
Published: August 2022

AbstractAimsThe incidence of in-hospital post-interventional complications and mortality after ablation of supraventricular tachycardia (SVT) vary among the type of procedure and most likely the experience of the centre. As ablation therapy of SVT is progressively being established as first-line therapy, further assessment of post-procedural complication rates is crucial for health care quality.Methods and resultsWe aimed at determining the incidence of in-hospital mortality and bleeding complications from SVT ablations in German high-volume electrophysiological centres between 2005 and 2020. All cases were registered by the German Diagnosis Related Groups—and the German Operation and Procedure Classification (OPS) system. A uniform search for SVT ablations from 2005 to 2020 with the same OPS codes defining the type of ablation/arrhythmia as well as the presence of a vascular complication, cardiac tamponade, and/or in-hospital death was performed. An overall of 47 610 ablations with 10 037 SVT ablations were registered from 2005 to 2020 among three high-volume centres. An overall complication rate of 0.5% (n = 38) was found [median age, 64; ±15 years; female n = 26 (68%)]. All-cause mortality was 0.02% (n = 2) and both patients had major prior co-morbidities precipitating a lethal outcome irrespective of the ablation procedure. Vascular complications occurred in 10 patients (0.1%), and cardiac tamponade was detected in 26 cases (0.3%).ConclusionThe present case-based analysis shows an overall low incidence of in-hospital complications after SVT ablation highlighting the overall very good safety profile of SVT ablations in high-volume centres. Further prospective analysis is still warranted to guarantee continuous quality control and optimal patient care.
Magnetic resonance imaging in patients with temporary external pacemakers
Authors: Fyenbo Daniel Benjamin , Jensen Morten Steen Kvistholm , Kronborg Mads Brix , Kristensen Jens , Nielsen Jens Cosedis , Witt Christoffer Tobias 
Published: August 2022

Abstract

Aims
To describe safety and feasibility of magnetic resonance imaging (MRI) in patients with transvenous temporary external pacemakers and whether artefacts affect the diagnostic image quality during cardiac MRI.

Methods and results
We reviewed records of all patients treated with temporary external pacing between 2016 and 2020 at a tertiary centre. Temporary pacing was established using a transvenous standard active fixation pacing lead inserted percutaneously and connected to a MRI-conditional pacemaker taped to the skin. All patients undergoing cardiac or non-cardiac MRI during temporary transvenous pacing were identified. Before MRI, devices were programmed according to guidelines for permanent pacemakers, and patients were monitored with continuous electrocardiogram during MRI. Of 827 consecutive patients receiving a temporary external pacemaker, a total of 44 (5%) patients underwent MRI (mean age 71 years, 13 [30%] females). Cardiac MRI was performed in 22 (50%) patients, while MRI of cerebrum, spine, and other regions was performed in the remaining patients. Median time from implantation of the temporary device to MRI was 6 (3–11) days. During MRI, we observed no device-related malfunction or arrhythmia. Nor did we detect any change in lead sensing, impedance, or pacing threshold. We observed no artefacts from the lead or pacemaker compromising the diagnostic image quality of cardiac MRI. MRI provided information to guide the clinical management in all cases.

Conclusion
MRI is feasible and safe in patients with temporary external pacing established with a regular MRI-conditional pacemaker and a standard active fixation lead. No artefacts compromised the diagnostic image quality.
Cellular Bioenergetics: Experimental Evidence for Alcohol-induced Adaptations
Authors: Simon Liz , Molina Patricia E 
Published: August 2022

Abstract
At-risk alcohol use is associated with multisystemic effects and end-organ injury, and significantly contributes to global health burden. Several alcohol-mediated mechanisms have been identified, with bioenergetic maladaptation gaining credence as an underlying pathophysiological mechanism contributing to cellular injury. This evidence-based review focuses on the current knowledge of alcohol-induced bioenergetic adaptations in metabolically active tissues: liver, cardiac and skeletal muscle, pancreas, and brain. Alcohol metabolism itself significantly interferes with bioenergetic pathways in tissues, particularly the liver. Alcohol decreases states of respiration in the electron transport chain, and activity and expression of respiratory complexes, with a net effect to decrease ATP content. In addition, alcohol dysregulates major metabolic pathways, including glycolysis, the tricarboxylic acid cycle, and fatty acid oxidation. These bioenergetic alterations are influenced by alcohol-mediated changes in mitochondrial morphology, biogenesis, and dynamics. The review highlights similarities and differences in bioenergetic adaptations according to tissue type, pattern of (acute vs. chronic) alcohol use, and energy substrate availability. The compromised bioenergetics synergizes with other critical pathophysiological mechanisms, including increased oxidative stress and accelerates cellular dysfunction, promoting senescence, programmed cell death, and end-organ injury.
Propagation of Pacemaker Activity and Peristaltic Contractions in the Mouse Renal Pelvis Rely on Ca2+-activated Cl− Channels and T-Type Ca2+ Channels
Authors: Grainger Nathan , Shonnard Cameron C , Quiggle Sage K , Fox Emily B , Presley Hannah , Daugherty Robbie , Shonnard Matthew C , Drumm Bernard T , Sanders Kenton M 
Published: August 2022

Abstract
The process of urine removal from the kidney occurs via the renal pelvis (RP). The RP demarcates the beginning of the upper urinary tract and is endowed with smooth muscle cells. Along the RP, organized contraction of smooth muscle cells generates the force required to move urine boluses toward the ureters and bladder. This process is mediated by specialized pacemaker cells that are highly expressed in the proximal RP that generate spontaneous rhythmic electrical activity to drive smooth muscle depolarization. The mechanisms by which peristaltic contractions propagate from the proximal to distal RP are not fully understood. In this study, we utilized a transgenic mouse that expresses the genetically encoded Ca2+ indicator, GCaMP3, under a myosin heavy chain promotor to visualize spreading peristaltic contractions in high spatial detail. Using this approach, we discovered variable effects of L-type Ca2+ channel antagonists on contraction parameters. Inhibition of T-type Ca2+ channels reduced the frequency and propagation distance of contractions. Similarly, antagonizing Ca2+-activated Cl− channels or altering the transmembrane Cl− gradient decreased contractile frequency and significantly inhibited peristaltic propagation. These data suggest that voltage-gated Ca2+ channels are important determinants of contraction initiation and maintain the fidelity of peristalsis as the spreading contraction moves further toward the ureter. Recruitment of Ca2+-activated Cl− channels, likely Anoctamin-1, and T-type Ca2+ channels are required for efficiently conducting the depolarizing current throughout the length of the RP. These mechanisms are necessary for the efficient removal of urine from the kidney.
Interventional inflammatory bowel disease: endoscopic therapy of complications of Crohn’s disease
Authors: Shen Bo 
Published: August 2022

Abstract
Endoscopic therapy for inflammatory bowel diseases (IBD) or IBD surgery-associated complications or namely interventional IBD has become the main treatment modality for Crohn’s disease, bridging medical and surgical treatments. Currently, the main applications of interventional IBD are (i) strictures; (ii) fistulas and abscesses; (iii) bleeding lesions, bezoars, foreign bodies, and polyps; (iv) post-operative complications such as acute and chronic anastomotic leaks; and (v) colitis-associated neoplasia. The endoscopic treatment modalities include balloon dilation, stricturotomy, strictureplasty, fistulotomy, incision and drainage (of fistula and abscess), sinusotomy, septectomy, banding ligation, clipping, polypectomy, endoscopic mucosal resection, and endoscopic submucosal dissection. The field of interventional IBD is evolving with a better understanding of the underlying disease process, advances in endoscopic technology, and interest and proper training of next-generation IBD interventionalists.
Natural Killer Cells Disrupt Nerve Fibers by Granzyme H in Atheriosclerotic Cerebral Small Vessel Disease
Authors: Yu Dafan , Cai Wei , Chen Xiaodong , Lu Danli , Hu Mengyan , Lu Tingting , Qin Bing , Wu Aimin , Ruan Hengfang , Lu Yaxin , Liu Zifeng , Wei Lei , Lu Zhengqi 
Published: August 2022

AbstractNatural killer (NK) cells are enriched in the central nervous system in aging-related atheriosclerotic cerebral small vessel disease (aCSVD), but their roles and underlying mechanism remain to be elucidated. To identify potential cytotoxic molecules released by NK cells in aCSVD lesions, proteomic analysis of cerebrospinal fluid (CSF), plasma, and peripheral NK cells from patients with aCSVD were performed. We found that integrin β2 (ITGB2), cathepsin D (CTSD), and granzyme H (GZMH) were highly expressed in NK cells. ITGB2 interacted with intercellular adhesion molecule 1 in vascular endothelial cells. As assessed by immunofluorescence and scanning electron microscopy of the blood–brain barrier model, transwell membranes covered with primary human brain microvascular endothelial cells and astrocytes, we demonstrated that the CTSD-mediated degradation of collagen in the blood–brain barrier depended on the cytotoxicity of NK cells in aCSVD. With the immunostaining in vitro and in vivo, GZMH disruption of demyelinated nerve fibers was reversed by cotreatment with the inhibitor 3,4-DCIC during white matter hyperintensity (WMH) in aCSVD. Our results indicate that NK cells contribute to CTSD-induced damage to the blood–brain barrier and GZMH-induced disruption of nerve fibers during WMH in aCSVD.
A Spotlight on Adaptation: Preimplementation of Montessori-Based Activity Programming in Long-Term Care Using the Framework for Reporting Adaptations and Modifications-Enhanced (FRAME)
Authors: Madrigal Caroline , Mills Whitney L , Keleher Virginia C , Pimentel Camilla B , Hartmann Christine W , Snow A Lynn , Camp Cameron , Hilgeman Michelle M 
Published: August 2022

AbstractBackground and ObjectivesEffectively adapting evidence-based interventions for nursing home (NH) implementation is a critical, yet underexamined, component of improving care quality. Montessori-based activity programming (MAP) is an evidence-based intervention that promotes person-centered care, engages persons living with dementia, and mitigates distress behaviors. Currently, there is sparse evidence of MAP in Department of Veterans Affairs NHs (i.e., community living centers [CLCs]). CLCs differ significantly from community NHs and require adaptations to support MAP use and sustainability. This study uses the Framework for Reporting Adaptations and Modifications-Enhanced (FRAME) to track changes made to MAP as an exemplar for clinicians and implementation scientists. This work fills a gap in adapting interventions through a detailed examination of the adaptation process in NHs.Research Design and MethodsQualitative and quantitative data were collected across 8 CLCs (e.g., advisory panel, staff interviews, training evaluations, field notes, and fidelity assessments). We used an iterative, rapid content analytic approach to triangulate findings and identify needed adaptations for the CLC setting.ResultsThirty-six adaptations were made. Most adaptions occurred during the preimplementation phase, were reactive, focused on training/evaluation, and involved researchers, intervention developers, and practitioners. All were fidelity-consistent with MAP. The most common goal across adaptations was increased reach/engagement of the intervention.Discussion and ImplicationsCLCs and community NHs can use findings to support intervention adaptation, and adapt and implement MAP to improve meaningful engagement for persons living with dementia and other residents. Future research should further evaluate and standardize FRAME for diverse users of complex interventions.
‘I have a healthy relationship with alcohol’: Australian midlife women, alcohol consumption and social class
Authors: Lunnay Belinda , Foley Kristen , Meyer Samantha B , Miller Emma R , Warin Megan , Wilson Carlene , Olver Ian N , Batchelor Samantha , Thomas Jessica A , Ward Paul R 
Published: August 2022

Summary
Alcohol consumption by Australian women during midlife has been increasing. Health promotion efforts to reduce alcohol consumption in order to reduce alcohol-related disease risk compete with the social contexts and value of alcohol in women’s lives. This paper draws on 50 qualitative interviews with midlife women (45–64 years of age) from different social classes living in South Australia in order to gain an understanding of how and why women might justify their relationships with alcohol. Social class shaped and characterized the different types of relationships with alcohol available to women, structuring their logic for consuming alcohol and their ability to consider reducing (or ‘breaking up with’) alcohol. We identified more agentic relationships with alcohol in the narratives of affluent women. We identified a tendency for less control over alcohol-related decisions in the narratives of women with less privileged life chances, suggesting greater challenges in changing drinking patterns. If classed differences are not attended to in health promotion efforts, this might mitigate the effectiveness of alcohol risk messaging to women.
COVID-19 preparedness and social dynamics in a Sub-Saharan Africa country, Benin
Authors: Maccaro Alessia , Piaggio Davide , Vignigbé Marius , Stingl Alexander , Pecchia Leandro 
Published: August 2022

Summary
This project aims to assess and analyse the perception and impact of the COVID-19 pandemic in Benin. The applied research methodology was interdisciplinary and combined field studies that used ethnographic and social research methods with coding and data analysis, leading to theoretical dilemmas, which were analysed from the viewpoint of bioethical reflection. Furthermore, biomedical engineering approaches were used to assess the preparedness to COVID-19. Despite the preparedness to COVID-19 due to the promoted governmental measures, a peculiar management of the pandemic emerged. The latter, although noteworthy, did not overcome the typical challenges of medical locations in low-resource settings. This, together with the controversial spread of information and local beliefs, caused significant economic and social consequences, exceeding the benefits related to the containment of the virus. This research highlights how the emotion of fear, in this specific situation, was herald of dramatic consequences, rather than having a heuristic and empowering effect.
A method for Identifying sensitivity of marine benthic invertebrates to ocean acidification through a biological traits approach
Authors: Gray P , Garcia C , Robinson C , Bremner J 
Published: August 2022

Abstract
Ocean acidification poses a major threat to the structure and diversity of marine ecosystems. The marine seabed sustains important ecosystem functions, and so understanding the sensitivity to increased pCO2 within benthic invertebrates is critical for informing future management strategies. Here, we explore a traits-based approach for estimating the sensitivity of benthic taxa to ocean acidification, using data from the western area of the North Sea. We selected 56 taxa across 11 taxonomic groups representative of the various habitats found in the region. Biological traits considered sensitive to elevated pCO2 were identified from literature review, and the taxa were scored for each trait to produce a total relative sensitivity (TRS) index. We investigated differences in sensitivity between the taxa and across habitats and explored whether sensitivity was spatially aggregated. Our analyses indicated that benthic species are sensitive to acidification, with 51% of the taxa scoring in the top three TRS bands overall, and hot spots of sensitivity being more widely distributed across the region than corresponding "cold spots" (low sensitivity). The opportunities and limitations of the approach are discussed.
Systematic review and meta-analysis comparing low-flow duration of extracorporeal and conventional cardiopulmonary resuscitation
Authors: Mandigers Loes , Boersma Eric , den Uil Corstiaan A , Gommers Diederik , Bělohlávek Jan , Belliato Mirko , Lorusso Roberto , dos Reis Miranda Dinis 
Published: August 2022

Abstract

OBJECTIVES
After cardiac arrest, a key factor determining survival outcomes is low-flow duration. Our aims were to determine the relation of survival and low-flow duration of extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) and if these 2 therapies have different short-term survival curves in relation to low-flow duration.

METHODS
We searched Embase, Medline, Web of Science and Google Scholar from inception up to April 2021. A linear mixed-effect model was used to describe the course of survival over time, based on study-specific and time-specific aggregated survival data.

RESULTS
We included 42 observational studies reporting on 1689 ECPR and 375 751 CCPR procedures. Of the included studies, 25 included adults, 13 included children and 4 included both. In adults, survival curves decline rapidly over time (ECPR 37.2%, 29.8%, 23.8% and 19.1% versus CCPR-shockable 36.8%, 7.2%, 1.4% and 0.3% for 15, 30, 45 and 60 min low-flow, respectively). ECPR was associated with a statistically significant slower decline in survival than CCPR with initial shockable rhythms (CCPR-shockable). In children, survival curves decline rapidly over time (ECPR 43.6%, 41.7%, 39.8% and 38.0% versus CCPR-shockable 48.6%, 20.5%, 8.6% and 3.6% for 15, 30, 45 and 60 min low-flow, respectively). ECPR was associated with a statistically significant slower decline in survival than CCPR-shockable.

CONCLUSIONS
The short-term survival of ECPR and CCPR-shockable patients both decline rapidly over time, in adults as well as in children. This decline of short-term survival in relation to low-flow duration in ECPR was slower than in conventional cardiopulmonary resuscitation.

Trial registration
Prospero: CRD42020212480, 2 October 2020.