bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preconception Mental Health, Socioeconomic Status, and Pregnancy Outcomes in Primiparous Women
Authors: Björkstedt Satu-Maarit , Koponen Hannu , Kautiainen Hannu , Gissler Mika , Pennanen Pirjo , Eriksson Johan G. , Laine Merja K. 
Published: July 2022

Background:One in four women of childbearing age has some degree of mental disorders and are, therefore, prone to both pregnancy complications and adverse health outcomes in their offspring. We aimed to evaluate the impact of preconception severe mental disorders on pregnancy outcomes in primiparous women.MethodsThe study cohort was composed of 6,189 Finnish primiparous women without previously diagnosed diabetes, who delivered between 2009 and 2015, living in the city of Vantaa, Finland. Women were classified to have a preconception severe mental disorder if they had one or more outpatient visits to a psychiatrist or hospitalization with a psychiatric diagnosis 1 year before conception. Data on pregnancies, diagnoses, and pregnancy outcomes were obtained from national registers at an individual level.ResultsPrimiparous women with preconception severe psychiatric diagnosis were younger, more often living alone, smokers, and had lower educational attainment and lower taxable income than women without psychiatric diagnosis (for all p &lt; 0.001). Of all women, 3.4% had at least one psychiatric diagnosis. The most common psychiatric diagnoses were depression and anxiety disorders. The most common comorbidity was the combination of depression and anxiety disorders. There were no differences in the need for respiratory treatments, admissions to the neonatal intensive care unit, or antibiotic treatments between the offspring's groups.ConclusionAlthough primiparous women had severe mental disorders, the well-being of newborns was good. The most common severe mental health disorders were depression and anxiety disorders, and psychiatric comorbidity was common. Women with severe mental disorders more often belonged to lower socioeconomic groups.
How Does Shyness Affect Chinese College Students' Tendency to Mobile Phone Addiction? Testing the Mediating Roles of Social Anxiety and Self-Control
Authors: Li Xinwei , Li Weijian , Liu Mengxian , Xiao Weilong , Zhou Hui 
Published: July 2022

Background and AimsMobile phone addiction among college students has gained considerable research attention because of its adverse effects on their health and academic performance. However, little is known about the mechanisms underlying the relationship between shyness and mobile phone addiction among college students.MethodsFour questionnaires were used to examine whether mobile phone addiction tendency was predicted by shyness and the mediating roles of social anxiety and self-control among 3,189 Chinese college students. Correlation and mediation analyses were conducted using Hayes PROCESS.ResultsThe results showed that (1) social anxiety (indirect effect = 0.22, 95% CI = 0.18–0.26) and self-control (indirect effect = 0.23, 95% CI = 0.21–0.25) played a partial mediating role in the relationship between shyness and mobile phone addiction tendency; (2) social anxiety and self-control also mediated the link between shyness and mobile phone addiction tendency sequentially (indirect effect = 0.10, 95% CI = 0.09 to 0.12).ConclusionThese results suggest that mobile phone addiction among shy college students could be eliminated by alleviating social anxiety and strengthening self-control.
Does YouTube Provide Qualified Patient Education Videos About Atrial Fibrillation?
Authors: Luo Chong , Bian Longrong , Jiang Lijie , Liang Weitao , Wu Zhong 
Published: July 2022

ObjectivePatients utilize the internet as a pathway to acquire knowledge of specific diseases. However, there are limited oversight and review mechanisms to ensure the authenticity of online information. This study aimed to evaluate the quality of video-based resources used to obtain information about atrial fibrillation (AF).MethodsMultiple AF-specific keywords were used to perform a systematic search of YouTube. Two independent reviewers reviewed the top 50 results of each keyword search. To record data, the Journal of the American Medical Association (JAMA) score, modified DISCERN score, AF-specific score (AFSS), and essential score (Escore) were used. The Kruskal-Wallis test was used for intergroup comparisons.ResultsA total of 74 videos that met the inclusion criteria were included in the analysis. In terms of video quality, 68% were poor, 19% were moderate, and 13% were exceptional. Videos submitted by publishers with a medical background were much less popular (p &lt; 0.05) than those submitted by publishers without a medical background. The video quality did not differ among those included in this study.ConclusionsSome videos on YouTube that are of real value are not as popular as those with low-quality content submitted by news agencies/media publishers. Furthermore, videos submitted by those with a medical background do not receive as much attention as others. It is important to acknowledge that video platforms should establish content and quality auditing mechanisms for videos. Furthermore, publishers should ensure that viewers receive accurate and complete knowledge and use more concise and accessible images or animations that are tailored to the audience.
Chinese and Global Burdens of Gastrointestinal Cancers From 1990 to 2019
Authors: Xie Wangcheng , Yang Tingsong , Zuo Jieliang , Ma Zhilong , Yu Weidi , Hu Zhengyu , Song Zhenshun 
Published: July 2022

BackgroundGastrointestinal (GI) cancers are an important component of the tumor. This study aimed to investigate the burden of six major GI cancers in China and globally from 1990 to 2019.MethodsWe conducted a cross-sectional study based on the Global Burden of Disease Study (GBD) 2019. Indicators on incidence, deaths, disability-adjusted life-years (DALYs), and risk factors for esophageal, stomach, liver, pancreatic, colon and rectum, and gallbladder and biliary tract cancers were collected and analyzed for time trends. The contribution of each cancer and the proportion of cases in China among global cases were further reported.ResultsGlobal incidence cases, death cases, and DALYs of GI cancers showed an overall ascending trend over the past 30 years, but there was temporal and geographical variation across cancer types. By 2019, colon and rectum cancer had overtaken stomach cancer as the most burdensome GI cancer globally. However, stomach cancer narrowly continued to be the most burdensome GI in China. In addition, the proportion of incidence and death cases of stomach, pancreatic, colon and rectum, and gallbladder and biliary tract cancers among global cases had further increased. It was noteworthy that the burden of liver cancer in China has been alleviated significantly.ConclusionGI cancers remain a major public health problem in China and globally. Despite the temporal and geographic diversity of different cancers, targeted primary and secondary prevention are still necessary for the future to face these unknown challenges.
Development of a Biosensor Based on Angiotensin‐Converting Enzyme II for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Human Saliva
Authors: Moreira Geisianny , Casso-Hartmann Lisseth , Datta Shoumen Palit Austin , Dean Delphine , McLamore Eric , Vanegas Diana 
Published: July 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for COVID-19. Infection in humans requires angiotensin-converting enzyme II (hACE2) as the point of entry for SARS-CoV-2. PCR testing is generally definitive but expensive, although it is highly sensitive and accurate. Biosensor-based monitoring could be a low-cost, accurate, and non-invasive approach to improve testing capacity. We develop a capacitive hACE2 biosensor for intact SARS-CoV-2 detection in saliva. Laser-induced graphene (LIG) electrodes were modified with platinum nanoparticles. The quality control of LIG electrodes was performed using cyclic voltammetry. Truncated hACE2 was used as a biorecognition element and attached to the electrode surface by streptavidin–biotin coupling. Biolayer interferometry was used for qualitative interaction screening of hACE2 with UV-attenuated virions. Electrochemical impedance spectroscopy (EIS) was used for signal transduction. Truncated hACE2 binds wild-type SARS-CoV-2 and its variants with greater avidity than human coronavirus (common cold virus). The limit of detection (LoD) is estimated to be 2,960 copies/ml. The detection process usually takes less than 30 min. The strength of these features makes the hACE2 biosensor a potentially low-cost approach for screening SARS-CoV-2 in non-clinical settings with high demand for rapid testing (for example, schools and airports).
The European Hernia Society Prehabilitation Project: A Systematic Review of Intra-Operative Prevention Strategies for Surgical Site Occurrences in Ventral Hernia Surgery
Authors: Wouters D. , Cavallaro G. , Jensen Kristian K. , East B. , Jíšová B. , Jorgensen L. N. , López-Cano M. , Rodrigues-Gonçalves V. , Stabilini C. , Berrevoet F. 
Published: July 2022

BackgroundVentral hernia repair is one of the most commonly performed surgical procedures worldwide. To reduce the risk of complications, pre- and intra-operative strategies have received increasing focus in recent years. To assess possible preventive surgical strategies, this European Hernia Society endorsed project was launched. The aim of this review was to evaluate the current literature focusing on pre- and intra-operative strategies for surgical site occurrences (SSO) and specifically surgical site infection (SSI) in ventral hernia repair.MethodsA systematic review was conducted and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Databases used were Pubmed and Web of Science. Original retrospective or prospective human adult studies describing at least one intra-operative intervention to reduce SSO after ventral hernia repair were considered eligible.ResultsFrom a total of 4775 results, a total of 18 papers were considered suitable after full text reading. Prehospital chlorhexidine gluconate (CHG) scrub appears to increase the risk of SSO in patients undergoing ventral hernia repair, while there is no association between any type of surgical hat worn and the incidence of postoperative wound events. Intraoperative measures as prophylactic negative pressure therapy, surgical drain placement and the use of quilt sutures seem beneficial for decreasing the incidence of SSO and/or SSI. No positive effect has been shown for antibiotic soaking of a synthetic mesh, nor for the use of fibrin sealants.ConclusionThis review identified a limited amount of literature describing specific preventive measures and techniques during ventral hernia repair. An advantage of prophylactic negative pressure therapy in prevention of SSI was observed, but different tools to decrease SSIs and SSOs continuously further need our full attention to improve patient outcomes and to lower overall costs.
Study on In Vitro Metabolism and In Vivo Pharmacokinetics of Beauvericin
Authors: Yuan Yu , Meng Guangpeng , Li Yuanbo , Wu Chunjie 
Published: July 2022

Beauvericin (BEA) is a well-known mycotoxin produced by many fungi, including Beaveria bassiana. The purpose of this study was to evaluate the in vitro distribution and metabolism characteristics as well as the in vivo pharmacokinetic (PK) profile of BEA. The in vitro metabolism studies of BEA were performed using rat, dog, mouse, monkey and human liver microsomes, cryopreserved hepatocytes and plasma under conditions of linear kinetics to estimate the respective elimination rates. Additionally, LC-UV-MSn (n = 1~2) was used to identify metabolites in human, rat, mouse, dog and monkey liver microsomes. Furthermore, cytochrome P450 (CYP) reaction phenotyping was carried out. Finally, the absolute bioavailability of BEA was evaluated by intravenous and oral administration in rats. BEA was metabolically stable in the liver microsomes and hepatocytes of humans and rats; however, it was a strong inhibitor of midazolam 1′-hydroxylase (CYP3A4) and mephenytoin 4′-hydroxylase (CYP2C19) activities in human liver microsomes. The protein binding fraction values of BEA were >90% and the half-life (T1/2) values of BEA were approximately 5 h in the plasma of the five species. The absolute bioavailability was calculated to be 29.5%. Altogether, these data indicate that BEA has great potential for further development as a drug candidate. Metabolic studies of different species can provide important reference values for further safety evaluation.
Urinary Neutrophil Gelatinase–Associated Lipocalin Predicts Intensive Care Unit Admission Diagnosis: A Prospective Cohort Study
Authors: Katz-Greenberg Goni , Malinchoc Michael , Broyles Dennis L. , Oxman David , Hamrahian Seyed M. , Maarouf Omar H. 
Published: July 2022

Key Points

Urinary neutrophil gelatinase–associated lipocalin (uNGAL) can distinguish intensive care unit (ICU) admission diagnosis, especially cardiogenic shock, where creatinine rise is a reflection of ischemia not injury.uNGAL is an early predictor of AKI and its severity in the ICU, which can be a tool to tailor AKI intervention in the ICU.uNGAL can predict AKI in the ICU despite urinary tract infection, which expands its utility.

Background
Acute kidney injury (AKI) is most commonly caused by tubular injury and is associated with a wide variety of critical illnesses. It is well known that urinary biomarkers can lead to the early identification of AKI. However, the ability of urinary biomarkers to distinguish between different types of critical illness has been less studied.

Methods
In this prospective cohort study, urinary neutrophil gelatinase–associated lipocalin (uNGAL) was measured in 107 patients consecutively admitted to the ICUs in our tertiary medical center. uNGAL samples were collected within 3–6 hours of admission to an ICU and measured by ELISA. All data were analyzed using R statistical software, and univariate analysis was used to determine the correlations of uNGAL levels with AKI stage, admission diagnoses, and ICU course.

Results
uNGAL level increased by a mean of 24-fold (SD 10–59) in ICU patients with AKI and demonstrated a significant correlation with the different AKI stages. uNGAL predicted the need for RRT, with values increased by more than 15-fold (P<0.05) in patients needing RRT, and remained a useful tool to predict AKI in ICU patients with a urinary tract infection. uNGAL level was correlated with certain ICU admitting diagnoses whereby uNGAL levels were lower in ICU patients with cardiogenic shock compared with other admission diagnoses (β=–1.92, P<0.05).

Conclusions
uNGAL can be used as an early predictor of AKI and its severity in patients admitted to the ICU, including the need for RRT. uNGAL may also help in distinguishing patients with cardiogenic shock from those with other critical illnesses and identifying those at risk for poor outcomes irrespective of the presence of AKI.
Environment Aspects in Moondraam Ulagappor Novel
Authors: M Rajakumari 
Published: July 2022

"Moondram Ulaga Por" is a novel written by the Great Poet Vairamuthu on Global warming and its threats. It was chosen as the best novel among the World Tamil novels by Dutto Sri Soma Trust and was awarded a cash prize of 10,000 American Dollars. The novel throws light on the ill effects of population explosion, materialism, modernism, excessive use of automobiles which pollutes the environment. Karuthamayee, Ishimoora, Chinnapandi and Emily are the main characters of the novel. Karuthamaayee is introduced as a proud farmer and he is depicted as a familiar character from our neighbourhood. Chinnapaandi is an efficient young man who has been graduated in Agriculture. He inspires the youngsters of his village with his knowledge and vigour. The writer tries to implore the readers by emphasizing on the fact that discipline and environmental sustainability are possible only if there is change individual's behaviour. The writer produces statistical evidences thereby creating awareness to the selfish society. This article focuses on the eco-critical reading of the novel as environmental sustainability is the need of the hour and more over it is the social responsibility of each and every individual.
Tactics of Neurosurgical Treatment of Posttraumatic Neuropathies with Chronic Pain Syndrome
Authors: Сидорович Р.Р. 
Published: July 2022

В статье описана тактика нейрохирургического лечения пациентов с хроническими болевыми синдромами, связанными с посттравматическими невропатиями, приводится перечень необходимых диагностических процедур и критериев для оценки консервативного лечения пациентов с данной патологией. На основании проведенного исследования разработаны перечень показаний, сроков и алгоритм тактики нейрохирургического лечения хронического болевого синдрома, а также проведен анализ ближайших и отдаленных результатов лечения, выполненного с помощью данного алгоритма.
The article describes the tactics of neurosurgical treatment of patients with chronic pain syndromes associated with post-traumatic neuropathies. The author provides a list of necessary diagnostic procedures and criteria for evaluating the conservative treatment of patients in this group. Based on the conducted retrospective study, the author developed a list of indications, terms and an algorithm for the tactics of neurosurgical treatment of chronic pain syndrome, and also analysed the immediate and long-term results of treatment performed using this algorithm.
Cerebral Infarction in a Pediatric Patient Associated with COVID-19 Infection. Case Report
Authors: Левшук О.Н. , Куликова С.Л. , Лихачев С.А. , Козич П.В. , Дмитриев В.В. 
Published: July 2022

Церебральная артериопатия, возникающая в силу различных механизмов, является наиболее частой причиной инфаркта мозга в детском возрасте. Одна из причин вторичных церебральных васкулитов у детей – недавно перенесенные либо активные вирусные инфекции. В статье представлено описание клинического случая ребенка 11 лет, у которого развился инфаркт мозга в бассейне средней мозговой артерии (СМА) вследствие COVID-19-ассоциированного церебрального васкулита с рецидивирующим тромбозом. Исключены наследственные тромбофилии, антифосфолипидный синдром, патология сердца и диссекция. Проведенная тромбэктомия в первые 4,5 часа от момента появления клинических симптомов обеспечила восстановление кровотока по СМА, однако ввиду развивающегося васкулита и продолженного стенозирования внутренней сонной артерии (ВСА) и СМА достигнутый эффект был кратковременным. Помимо хирургического лечения применяли глюкокортикостероиды (ГКС), антикоагулянты и антиагреганты. При наблюдении в катамнезе (1,5 года) рецидивов инфаркта мозга не наблюдалось. Представленное клиническое наблюдение демонстрирует, что инфекция COVID-19 может быть причиной инсульта не только у взрослых, но и у детей, в связи с чем требуется разработка рекомендаций по лечению пациентов детского возраста с инфарктом мозга, ассоциированным с COVID-19-инфекцией.
Cerebral arteriopathy, occurring due to various mechanisms, is the most common cause of cerebral infarction in childhood. One of the causes of secondary cerebral vasculitis in children is recent or active viral infections. The article presents a description of a clinical case of an 11-year-old patient who has had a cerebral infarction in the middle cerebral artery (MCA) due to COVID-19-associated cerebral vasculitis with recurrent thrombosis. Hereditary thrombophilias, antiphospholipid syndrome, cardiac pathology and dissection have been excluded. Thanks to thrombectomy that has been carried out during 4.5 hours after the clinical symptoms appeared, the blood flow in the MCA has been restored. However, due to developing vasculitis and continuing stenosis of the internal carotid artery (ICA) and MCA, only short-term effect has been achieved. In addition to surgical treatment, glucocorticosteroids (GCS), anticoagulants and antiaggregants have been used. During catamnesis (1.5 years), there have been no recurrences of cerebral infarction. The clinical observation presented shows that COVID-19 infection can cause stroke not only in adults, but also in children, and therefore it is necessary to work out recommendations for the treatment of pediatric patients with cerebral infarction associated with COVID-19 infection.
Kualitas fisik daging sapi di pasar tradisional dan pasar modern Kota Manado
Authors: Simanjuntak T.M.S. , Rembet G.D.G. , Sondakh E.H.B. , Maaruf W. 
Published: July 2022

Penelitian ini bertujuan untuk mengukur dan membandingkan kualitas sifat fisik daging sapi yang ada di pasar tradisional dan pasar modern di Kota Manado. Materi yang digunakan dalam penelitian ini adalah daging sapi segar yang dijual di pasar tradisional dan pasar modern. Penelitian ini dilaksanakan survey terhadap beberapa sumber daging yang beredar di kota Manado. Penentuan sampel pasar dilakukan dengan metode simple random sampling. Pasar yang dijadikan obyek penelitian adalah pasar tradisional, dan pasar modern yang menjual daging sapi. Enam pasar diambil sebagai sampel, tiga pasar tradisional dan tiga pasar modern. Pasar tradisional, dan pasar modern sebagai perlakuan dan diambil sebanyak 12 sample untuk setiap perlakuan. Data dianalisis menggunakan uji t tidak berpasangan dengan asumsi varians yang sama. Variable yang diukur adalah: pH, kadar air, daya mengikat air, dan susut masak. Hasil penelitian yang diperoleh menunjukan bahwa semua variable daging yang diukur terdiri dari pH dari pasar tradisional 5,58 dan pasar modern 5,3, daya ikat air dari pasar tradisional 29,93% dan pasar modern 26,90% kadar air pasar tradisional 75,24% dan pasar modern: 76,19%, susut masak pasar tradisional 0,43 dan pasar modern 0,41. Kesimpulan dari penelitian ini menunjukan bahwa daging sapi segar yang dijual di pasar tradisional dan modern yang ada di Kota Manado mempunyai kualitas yang sama dan layak untuk dikonsumsi. Kata kunci: Daging sapi, pasar tradisional dan pasar modern, sifat fisik daging
Estimations of secondary electron emission coefficients of Si, SiO2, and polyimide electrodes in dual-frequency capacitively coupled discharge
Authors: Takagi Shigeyuki , Nakaegawa Tatsuhiro , Hsiao Shih-Nan , Sekine Makoto 
Published: July 2022

Abstract
In a dual-frequency capacitively coupled Ar plasma, the secondary electron emission (SEE) coefficients were estimated using a 2D fluid model and experiments. The electron density was measured in the plasma chamber with the upper and lower electrodes of Si. The electron density was calculated by changing the SEE coefficient. The SEE coefficient of the Si electrode was estimated to be 0.06 so that the electron density of the 2D fluid model was close to that of the experimental result. Next, the electron density was measured in the chamber of the lower electrode covered with SiO2 and polyimide, and the SEE coefficients were estimated by comparing experiments and the 2D fluid model. The SEE coefficients of the SiO2 and the polyimide were estimated to be 0.24 and 0.22, respectively. Moreover, The SEE coefficients of SiO2 were almost the same in the range between 300 and 500 W of the lower electrode power.