bluuebunny/crossref_metadata_2025_split huggingface dataset:
The backbone symptoms of depression: a network analysis after the initial wave of the COVID-19 pandemic in Macao
Authors: Zhao Yan-Jie , Bai Wei , Cai Hong , Sha Sha , Zhang Qinge , Lei Si Man , Lok Ka-In , Chow Ines Hang Iao , Cheung Teris , Su Zhaohui , Balbuena Lloyd , Xiang Yu-Tao 
Published: September 2022

Background
The coronavirus disease 2019 (COVID-19) pandemic disrupted the working lives of Macau residents, possibly leading to mental health issues such as depression. The pandemic served as the context for this investigation of the network structure of depressive symptoms in a community sample. This study aimed to identify the backbone symptoms of depression and to propose an intervention target.

Methods
This study recruited a convenience sample of 975 Macao residents between 20th August and 9th November 2020. In an electronic survey, depressive symptoms were assessed with the Patient Health Questionnaire-9 (PHQ-9). Symptom relationships and centrality indices were identified using directed and undirected network estimation methods. The undirected network was constructed using the extended Bayesian information criterion (EBIC) model, and the directed network was constructed using the Triangulated Maximally Filtered Graph (TMFG) method. The stability of the centrality indices was evaluated by a case-dropping bootstrap procedure. Wilcoxon signed rank tests of the centrality indices were used to assess whether the network structure was invariant between age and gender groups.

Results
Loss of energy, psychomotor problems, and guilt feelings were the symptoms with the highest centrality indices, indicating that these three symptoms were backbone symptoms of depression. The directed graph showed that loss of energy had the highest number of outward projections to other symptoms. The network structure remained stable after randomly dropping 50% of the study sample, and the network structure was invariant by age and gender groups.

Conclusion
Loss of energy, psychomotor problems and guilt feelings constituted the three backbone symptoms during the pandemic. Based on centrality and relative influence, loss of energy could be targeted by increasing opportunities for physical activity.
“A flor do amadurecimento”:
Authors: Rios Luís Felipe 
Published: September 2022

O texto discute resultados de inquérito comportamental com 380 homens que fazem sexo com homens (HSH) e entrevistas narrativas com vinte dos respondentes do inquérito sobre experiências sexuais na infância. As primeiras experiências sexuais relatadas ocorreram na segunda infância e tinham o sentido de brincadeiras. Até os 12 anos, 46,8% dos respondentes relataram ter dado o primeiro beijo na boca, 46,3% realizado carícias mútuas (sarração) e 36,3% masturbação solitária (punheta). As práticas penetrativas (sexo oral e anal) tiveram menores frequências, concentrando-se por volta dos 12 anos. Nas narrativas, as práticas penetrativas estiveram relacionadas a um reposicionamento subjetivo, em que as crianças tinham mais consciência sobre os significados da sexualidade do mundo adulto, sentiam-se prontas corporal e subjetivamente (dominavam a malícia) para a realização do tesão com outros garotos, geralmente um amigo mais velho. A análise aponta para a centralidade das estilizações de gênero e de idade na formação de desejos e parcerias. Também chama atenção paras as investidas estigmatizantes da família, vizinhança, igreja e escola, cujo efeito é expresso no sentimento de confusão e produz uma variedade de cicatrizes subjetivas, como depressão, ideações e tentativas de suicídio. Situações que pedem robustas ações de garantia dos direitos sexuais das crianças com práticas homossexuais e transgêneras.
Geospatial Analysis of Organ Transplant Referral Regions
Authors: Schappe Tyler , Peskoe Sarah , Bhavsar Nrupen , Boulware L. Ebony , Pendergast Jane , McElroy Lisa M. 
Published: September 2022

ImportanceSystem and center-level interventions to improve health equity in organ transplantation benefit from robust characterization of the referral population served by each transplant center. Transplant referral regions (TRRs) define geographic catchment areas for transplant centers in the US, but accurately characterizing the demographics of populations within TRRs using US Census data poses a challenge.ObjectiveTo compare 2 methods of linking US Census data with TRRs—a geospatial intersection method and a zip code cross-reference method.Design, Setting, and ParticipantsThis cohort study compared spatial congruence of spatial intersection and zip code cross-reference methods of characterizing TRRs at the census block level. Data included adults aged 18 years and older on the waiting list for kidney transplant from 2008 through 2018.ExposuresEnd-stage kidney disease.Main Outcomes and MeasuresMultiple assignments, where a census tract or block group crossed the boundary between 2 hospital referral regions and was assigned to multiple different TRRs; misassigned area, the portion of census tracts or block groups assigned to a TRR using either method but fall outside of the TRR boundary.ResultsIn total, 102 TRRs were defined for 238 transplant centers. The zip code cross-reference method resulted in 4627 multiple-assigned census block groups (representing 18% of US land area assigned to TRRs), while the spatial intersection method eliminated this problem. Furthermore, the spatial method resulted in a mean and median reduction in misassigned area of 65% and 83% across all TRRs, respectively, compared with the zip code cross-reference method.Conclusions and RelevanceIn this study, characterizing populations within TRRs with census block groups provided high spatial resolution, complete coverage of the country, and balanced population counts. A spatial intersection approach avoided errors due to duplicative and incorrect assignments, and allowed more detailed and accurate characterization of the sociodemographics of populations within TRRs; this approach can enrich transplant center knowledge of local referral populations, assist researchers in understanding how social determinants of health may factor into access to transplant, and inform interventions to improve heath equity.
Solution‐Tube‐Based Volume Effect Triboelectric Nanogenerator with Salt and pH Sensitivity
Authors: Zhou Qitao , Wang Boyou , Gao Along , Xu Wenxia , Zhou Kang , Pan Jing , Meng Guowen , Pan Caofeng , Xia Fan 
Published: September 2022

AbstractDue to the advantages of natural softness and flexibility of water, liquid–solid‐based triboelectric nanogenerators (TENGs) have aroused wide attention recently and much effort has been devoted to improving its output performance. Herein, the performance of liquid–solid‐based TENG is greatly improved through two simple steps. First, an end electrode is added into the traditional tube‐based TENG and the volume effect is successfully realized, with the output voltage improved by ≈40 times to 240 V. Then, the output voltage of the tube‐based TENG can be further improved to 461 V by replacing water with NaOH solution and an impressive peak power density of 1910 Wm−3 and an average power density of 459 Wm−3 can be achieved. Additionally, the demonstration shows that the solution‐tube‐based volume effect TENG can work well at various operation modes and generate power from multiple mechanical energy sources. In addition to wearable human motion energy recovery, wave energy recovery, and electrochemical cathodic protection systems, the device also shows its application potential in biochemical sensing based on the solute concentration‐dependent output signal.
Indocyanine green‐fluorescent imaging for a detection of accessory pancreatic duct in pancreas‐preserving duodenectomy
Authors: Ito Ryota , Mise Yoshihiro , Tanaka Haruka , Miyashita Mamiko , Saiura Akio 
Published: September 2022

AbstractPancreas‐preserving duodenectomy is indicated for select patients with a duodenal tumor in the second portion. In this procedure, identification and closure of the accessory pancreatic duct is important to prevent postoperative pancreatic fistula. A 63‐y‐old man was diagnosed with duodenal mucosal carcinoma in the second portion, with invasion of the major ampullary. We performed pancreas‐preserving duodenectomy. Intraoperatively, indocyanine green‐fluorescent imaging identified the accessory pancreatic duct clearly and it was successfully closed. Postoperative pancreatic fistula did not occur. Indocyanine green‐fluorescent imaging is effective in identifying the accessory pancreatic duct in pancreas‐preserving duodenectomy.
The use of nitrous oxide ‘cracking’ technology in the labour ward: a case report and patient account
Authors: Khan‐Perez J. , MacCarrick T. , Martin F. 
Published: September 2022

SummaryNitrous oxide is a common choice of labour analgesia in many countries. However, its use is associated with significant cost to the environment as well as potential risks of long‐term occupational exposure. Our hospital is one of a small number of healthcare providers in the United Kingdom trialling technology which catalytically destroys (‘cracks’) nitrous oxide to reduce greenhouse gas emissions and occupational exposure. When used in the setting of inhaled analgesia, cracking technology relies on capturing the patient's exhaled breath via a facemask or mouthpiece, a technique which requires some user skill and may be challenging for patients. In this report, we present the case of a primiparous 35‐year‐old consultant anaesthetist, who used nitrous oxide cracking technology with inhaled nitrous oxide analgesia (via a facemask) during labour. We present the patient's experiences and discuss the implications of using such technology on ambient nitrous oxide levels in the delivery room. Notably, despite this patient's professional expertise and familiarity with facemask use, nitrous oxide remained detectable throughout her labour, although generally at low levels. This illustrates that whilst this technology has the potential to reduce ambient nitrous oxide levels, its efficacy may vary depending on how it is used, with implications for patient education and support.
An Origami Paper‐Based Analytical Device Coupled with Fast‐Responding Functional RNA Superstructures for Tetracycline Detection
Authors: Shi Jiarong , Zhang Rui , Chang Yangyang , Liu Meng 
Published: September 2022

AbstractRapid and sensitive detection of tetracycline (TC) in the aquatic environment is important for the environmental ecosystem and human health. Herein, we presented on the first attempt to construct a fast‐responding gating system by using horseradish peroxidase (HRP)‐loaded functional RNA superstructures (HRP@3D RNA). Proteins were directly loaded into 3D RNA by the rolling circle transcription (RCT) reaction. We found that the specificity of aptamer‐ligand interaction could serve as a triggered manner to release the loaded HRP from 3D RNA. The above general scheme showed a few minutes of rapid release kinetics. According to the controlled‐release mechanism, we designed a disposable origami paper‐based analytical device (doPAD) coupled with HRP@3D RNA for colorimetric detection of TC. This doPAD can realize target recognition and signal readout by taking advantage of the unique spatial control advantages of 3D origami, thus generating a signal of color change that is positively related to the concentration of TC. This doPAD achieved the quantitative analysis of TC with a limit of detection of 10 nM within 41 min. We envision that the platform will be widely used in the field of environmental monitoring and biosensing.
Crowdsourced data reveal multinational connectivity, population demographics, and possible nursery ground of endangered oceanic manta rays in the Red Sea
Authors: Knochel Anna M. , Cochran Jesse E. M. , Kattan Alexander , Stevens Guy M. W. , Bojanowksi Elke , Berumen Michael L. 
Published: September 2022

Abstract

Despite the large size and economic value of the species, populations of oceanic manta ray (Mobula birostris) are often poorly studied and almost completely undescribed in the Red Sea. Here, photo‐identification (photo‐ID) was used to provide the first description of M. birostris movement patterns and population demographics for the northern Red Sea.
Images collated from social media, researchers, and photo‐ID databases from 2004 to 2021 identified 267 individual M. birostris from 395 sightings in Egypt, Israel, Jordan, Saudi Arabia, and Sudan. Sexual parity was observed in the population with 134 females, 111 males, and 22 individuals of undetermined sex. Nearly half of the individuals in this study were first identified through social media searches, highlighting the value of the sightings data collected by the public.
The regular presence of juveniles in Sharm el‐Sheikh, Egypt, indicates that this area is a potential nursery, which is the second identified for this species globally and the first in the Indo‐Pacific. Encounter data from this study recorded the first known movements of juvenile M. birostris and demonstrate that they can travel long distances of at least 525 km.
Within the recorded population, 24.7% (n = 67) of individuals were resighted, including 21 oceanic manta rays that were encountered in more than one location. These records reveal long‐distance migrations of up to 700 km and confirm the international connectivity of M. birostris in the Red Sea. The lagged identification rate data are best fitted with an open‐population model, implying that the northern Red Sea is represented by one well‐mixed population.
The baseline data presented here should encourage the expansion of directed research and citizen science initiatives for M. birostris. Increased knowledge of movement patterns and site use will be crucial to successfully protecting this endangered species in a region characterized by high levels of shipping traffic, unregulated fisheries, and extensive coastal development.
A reappraisal of pediatric thoracic surface anatomy
Authors: Şener Umut , Tellioğlu Ayfer Metin , Polat Yasemin Durum 
Published: September 2022

AbstractAccurate knowledge of surface anatomy is essential for physical examination, invasive procedures, and anatomy education. Individual factors such as age make surface landmarks variable so accurate descriptions are needed. The aim of this study is to describe age‐related surface landmarks for intrathoracic structures in children. A total of 156 thoracic computed tomography scans of children aged 0–18 years were categorized into six groups, and the associations between major intrathoracic structures and surface landmarks were analyzed. Sternal angle is an accurate surface landmark for the azygos vein‐superior vena cava junction in all age groups. However, the aortic arch (except in the 0–1 year group), the bifurcation of the pulmonary trunk and the tracheal bifurcation in those aged 15–18 years were not within this plane. The left brachiocephalic vein was located behind the ipsilateral sternoclavicular joint except in the 1–3 years group, and the right was behind it in children older than 6 years. The apex of heart was at the 5th intercostal space level in the 0–1 and 12–18 years groups; however, it was higher in the other groups. The lower borders of the lungs were at the sixth costal cartilage level in the midclavicular line, eighth intercostal space level in the midaxillary line, and T12 adjacent to the vertebral column in the 15–18 years group; the lower borders were at higher levels in younger children. Defining the variations in surface anatomy by in vivo studies will increase its clinical and pedagogical value.
The relationship between immediate postmastectomy reconstruction modalities and survival benefits in patients with triple negative breast cancer
Authors: Dai Luyao , Cui Hanxiao , Bao Yuanhang , Hu Liqun , Zhou Zhangjian , Wang Meng , Lin Shuai , Wu Hao , Kang Huafeng , Ma Xiaobin 
Published: September 2022

AbstractIntroductionImmediate postmastectomy reconstruction for breast cancer has been widely used due to its unique esthetic and psychological effects. However, no other population‐based study has investigated the effects of different reconstruction types on the survival in patients with triple negative breast cancer (TNBC).MethodsWe selected patients who met the eligibility criteria from the Surveillance, Epidemiology, and End Results cancer registry (N = 9760). We then assessed the effect of different reconstructive surgical approaches (implant, autologous, implant and autologous combined reconstruction) on the overall survival (OS) and breast cancer‐specific survival (BCSS) by using the Kaplan–Meier survival curve and Cox proportional hazard regression analyses. The nomograms were used to predict OS and BCSS. And the competitive risk model was used to assess breast cancer‐specific death (BCSD) and non‐breast cancer‐specific death (NBCSD).ResultsStatistical analysis suggested that the three reconstruction methods had better OS and BCSS with lower hazard than mastectomy alone (log‐rank test, p < 0.05). Multivariate stratified analysis showed that patients aged 40–60 years had the greatest improvement in OS (Adjusted hazard ratio [AHR], 0.646; 95% Confidence Interval [CI], 0.439–0.950; p = 0.026) with combined reconstruction. BCSS could be improved only by implant reconstruction (AHR, 0.672; 95% CI, 0.514–0.878; p = 0.004). In addition, autologous reconstruction (AHR, 0.570; 95% CI, 0.350–0.929; p = 0.024) and implant reconstruction (AHR, 0.538; 95% CI, 0.339–0.853; p = 0.008) improved OS in patients >60 years of age. The survival prediction model quantified the survival benefits of TNBC patients undergoing different surgeries. Moreover, the C‐indexes showed the good predictive ability of the nomograms.ConclusionsOur results suggest that for TNBC patients, there is a survival benefit of immediate postmastectomy reconstruction compared with mastectomy alone. Among them, implant reconstruction has the most obvious advantage.
A rare case of melanoma erysipeloides
Authors: Rekik Mariem , Kouki Chaima , kammoun Nadine , Sellami khadija , Triki Mariem , Boudaya Sonia , Bahloul Emna , Amouri Mariem , Boudawara Tahya , Turki Hamida 
Published: September 2022

AbstractMalignant melanoma presenting as an inflammatory skin metastasis has been described but is an exceedingly rare phenomenon. We report a case of inflammatory metastasis of cutaneous melanoma (CM).
Shared histological and immunohistological findings in two patients with generalized vitiligo associated with autoimmune atrophic gastritis
Authors: Ghalamkarpour Fariba , André Muriel Cario , Gauthier Yvon 
Published: September 2022

AbstractThe prevalence of autoimmune atrophic gastritis (AAG) in vitiligo patients was estimated at about 15%. In both conditions, a release of specific antibodies and an autoimmune destruction of target cells (melanocytes in vitiligo, parietal cells (PC) in AAG) mediated by CD8‐T lymphocytes was demonstrated to perform a comparative histological study of vitiligo skin and AAG mucosa. In two patients with concomitant vitiligo and AAG, biopsies from the vitiligo lesions and gastric mucosa from corpus fundus were performed. Sections were immunostained with E‐cadherin, Coll IV, CD8, CD20, CD4 antibodies. The skin sections also were stained with HES, HMB45, MITF. Common histological findings were found in both diseases. Adhesivity impairment with down expression of E‐cadherin and Coll IV was objectivated. The protruding MITF+melanocytes and the detached PC were surrounded by an infiltrate including CD8 and CD4. CD8 was infiltrating the epidermis in close contact with the remaining melanocytes and the gastric glands around the remaining PC. In both diseases, the autoimmune process could be preceded by a detachment of either melanocytes in vitiligo or PC in AAG possibly in relation to an initial adhesivity impairment of these cells. Common autoimmune mechanisms could be suggested for both diseases.
Methamphetamine poisoning due to body packer swallowing in a prisoner
Authors: Rouhani Ramin , Zakariaei Zakaria , Malakian Abdollah , Banimostafavi Elham Sadat , Soleymani Mostafa 
Published: September 2022

AbstractIndividuals who introduce illicit substances such as opioids and amphetamines into the gastrointestinal tract by swallowing or inserting them into the rectum are known as body packers. We describe a prisoner who developed severe poisoning symptoms after swallowing amphetamine packets and was promptly removed by laparotomy.
Clean energy strategies and pathways to meet British Columbia's decarbonization targets
Authors: Wang Haoqi , Bi Xiaotao , Clift Roland 
Published: September 2022

AbstractBritish Columbia (BC) recently released the CleanBC policy framework to promote clean energy and mitigate greenhouse gas (GHG) emissions. However, CleanBC lacks concrete measures to reverse the growth of energy demand. Although BC has rich biomass and hydroelectric resources, it remains unclear whether these renewable resources will be enough to meet future energy demand. In this work, the potential in BC for increasing production and use of bioenergy, renewable electricity, and low‐carbon hydrogen was assessed, and the most efficient measures were identified. Energy scenarios were constructed to explore BC's future renewable energy demands for meeting GHG mitigation targets. The results show that CleanBC will drastically raise renewable energy demands but fail to achieve the 2030 target without radical demand reduction. Seen as the core strategy in CleanBC, electrification will require at least 60 PJ of additional electricity supply for 2030 and 160 PJ for carbon neutrality in 2050. This implies implementing wind and solar generation in capacities comparable to massive hydroelectric projects. Alternative to electrification is the bioenergy‐centred strategy. Existing waste biomass must be fully exploited; even then, roughly 250 and 460 PJ of additional primary bioenergy will be needed for 2030 and 2050, respectively, well beyond any foreseeable waste supply within BC. Hence, it is essential to utilize all the available biomass and renewable electricity resources and promote a diversified renewable energy portfolio. Hydrogen used as an energy carrier must be produced from natural gas with carbon capture to avoid competition for the limited renewable energy resources.
Molecular annotation of extramedullary acute myeloid leukemia identifies high prevalence of targetable mutations
Authors: Ball Somedeb , Knepper Todd C. , Deutsch Yehuda E. , Samra Wassim , Watts Justin M. , Bradley Terrence J. , Chan Onyee , Hussaini Mohammad Omar , Zhang Ling , Sweet Kendra L. , Kuykendall Andrew T. , Talati Chetasi , Padron Eric , Komrokji Rami S. , Lancet Jeffrey E. , Sallman David A. 
Published: September 2022

BackgroundGenomic landscape of extramedullary acute myeloid leukemia (EM‐AML), including myeloid sarcoma (MS) and leukemia cutis (LC), is not well characterized. The potential utility of next‐generation sequencing (NGS) using EM tissue is not established.MethodsIn this multicenter retrospective study, clinical and NGS data were collected on patients with EM‐AML. All statistical analyses were performed in SPSS Statistics (v 26).ResultsOur study included 58 patients with EM‐AML. The median age at diagnosis was 62 years; 59% of patients had MS and 33% had LC. EM‐AML was isolated (i.e., without blood or marrow involvement) in 31% and was first noted at relapse in 60% of patients. Median overall survival in our cohort was 18.2 months overall, with 19.1 months and 11.6 months in the newly diagnosed and the relapsed/refractory patients, respectively. At least one targetable or potentially targetable alteration was present in 52% of patients with EM‐site NGS, with 26% IDH1, 21% NPM1, 11% IDH2, 6% FLT3, and 13% KMT2A‐PTD. Mutations in IDH1 were significantly more prevalent on NGS from EM tissue than non‐EM (blood or marrow) samples (26% vs. 3%; p = .030). Three of four patients treated with IDH inhibitors based on EM‐site NGS experienced a complete response.ConclusionsTargetable mutations are frequent in EM‐AML and EM‐site NGS is warranted for selecting potential targeted therapies for patients with EM‐AML.