bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN ANTARA HARGA DIRI DENGAN INTENSI KEKERASAN DALAM PACARAN PADA MAHASISWA PROGRAM STUDI TEKNIK MESIN UNIVERSITAS MUHAMMADIYAH SURAKARTA
Authors: Wardhani Febryta , Indrawati Endang Sri 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui hubungan antara harga diri dengan intensi kekerasan dalam pacaran. Populasi pada penelitian ini adalah mahasiswa Program Studi Teknik Mesin Universitas Muhammadiyah Surakarta yang memenuhi karakteristik sejumlah 92 orang. Metode yang di gunakan dalam penelitian ini adalah metode kuantitatif. Penelitian ini menggunakan teknik convenience sampling. Pengumpulan data menggunakan dua buah skala yaitu skala harga diri (32 aitem valid, α = 0.915) dan skala intensi kekerasan dalam pacaran (28 aitem valid, α = 0.938). Hasil penelitian ditunjukan dengan angka koefisien korelasi sebesar -0,523 dengan p = 0,000 (p < 0,05). Korelasi negatif ini memiliki arti bahwa semakin tinggi harga diri maka semakin rendah intensi kekerasan dalam pacaran pada mahasiswa Program Studi Teknik Mesin Universitas Muhammadiyah Surakarta, demikian pula sebaliknya semakin rendah harga diri maka semakin tinggi intensi kekerasan dalam pacaran pada mahasiswa Program Studi Teknik Mesin Universitas Muhammadiyah Surakarta. Harga diri memberikan sumbangan efektif sebesar 27,4% terhadap intensi kekerasan dalam pacaran.
Analisa Komitmen Manajemen Rumah Sakit (RS) Terhadap Keselamatan Dan Kesehatan Kerja (K3) Pada RS Prima Medika Pemalang
Authors: Ivana Azza , Widjasena Baju , Jayanti Siswi 
Published: September 2022

Rumah sakit (RS) Prima Medika Pemalang merupakan institusi pelayanan kesehatan yang menyelenggarakan pelayanan kesehatan. Potensi bahaya di RS disebabkan oleh faktor biologi, faktor kimia, faktor ergonomi, faktor fisik, faktor psikososial, serta bahaya mekanik, bahaya listrik, limbah RS yang dapat mengakibatkan penyakit, dan kecelakaan akibat kerja. Berdasarkan potensi bahaya di RS dan untuk mencegah dan mengurangi resiko bahaya tersebut, maka perlu ditetapkan standar Keselamatan dan Kesehatan Kerja di RS (K3RS) sedangkan pada RS Prima Medika bagian yang menangani masalah K3 secara khusus belum terbentuk. Tujuan dari penelitian ini adalah untuk menganalisis komitmen manajemen RS terhadap Keselamatan dan Kesehatan Kerja pada RS Prima Medika Pemalang. Penelitian ini adalah jenis penelitian kualitatif dengan metode observasi dan wawancara mendalam. Informan pada penelitian ini yaitu direktur RS, kepala sub bagian umum RS, seksi keperawatan RS, kepala ruangan keperawatan (IGD dan bangsal) dan kepala ruangan farmasi. Hasil penelitian ini diketahui bahwa RS Prima Medika Pemalang sudah memiliki komitmen awal yang diungkapkan secara lisan untuk membentuk struktur K3RS akan tetapi belum diwujudkan dalam bentuk kebijakan secara tertulis dan struktur organisasi yang khusus untuk K3RS, namun RS sudah memiliki dana yang digunakan untuk keperluan K3RS seperti pengadaan Alat Pelindung Diri, pembelian APAR dan alat – alat keselamatan lainnya
Evaluasi Program Inisiasi Menyusu Dini Oleh Bidan Di Rumah Sakit Panti Wilasa Citarum Semarang
Authors: H. Siregar Hamida , Sriatmi Ayun , Kartika Wulan Lucia Ratna 
Published: September 2022

Sesuai target Millenium Development Goals (MDG’s) (AKI) di Indonesia sampai 2015 adalah 102 per 100.000. Dalam rangka mengatasi masalah AKI dan AKB, Departemen Kesehatan mengeluarkan kebijakan yang mengacu kepada intervensi strategis dalam upaya safe motherhood yang salah satunya yaituInisiasi menyusu dini. Rumah Sakit Panti Wilasa Citarum Semarang merupakan Rumah Sakit Sayang Ibu dan Bayi yang melakukan program IMD. Data tahun 2010 terdapat 43,1% persalinan normal dengan IMD dan tahun 2011 sebanyak 34.6%. Berdasarkan studi pendahuluan yang dilakukan pada 3 ibu bidan diketahui bahwa 2 dari 3 pelaksana IMD belum melaksanakan IMD sesuai dengan pedoman pelaksanaan IMD dan Rumah Sakit Panti Wilasa Citarum Semarang belum melaksanakan evaluasi selama 5 tahun terakhir. Tujuan penelitian untuk mengukur pelaksanaan program IMD oleh bidan di Rumah Sakit Panti Wilasa Citarum Semarang. Penelitian dilaksanakan di ruang bersalin dengan menggunakan pendekatan kualitatif deskriptif dengan 8 informan utama dan 11 informan triangulasi. Pengumpulan data dilakukan dengan indepth interview serta teori system Azrul Azwar digunakan sebagai kerangka konsep dengan analisis data secara induktif. Dari hasil penelitian dapat disimpulkan bahwa bidan sudah cukup berkulitas dan berkompeten dalam pelaksanaan IMD, sarana dan prasarana sudah cukup baik namun tidak tersedia Klinik Laktasidan KP-ASI sebagai sarana pendukung program, IMD, perencanaan anggaran IMD sudah cukup yaitu diperoleh dari rumah sakit dan dikelola oleh TIM RSSIB, protap IMD sudah tersedia di rumah sakit dan disahkan oleh Direktur sebagai petunjuk kerja IMD, perencanaan kegiatan IMD sudah cukup baik yaitu perencanaan tenaga IMD, dana dan sarana dan prasarana. Pelaksanaan kegiatan IMD belum cukup baik, bidan tidak melaksanakan IMD sesuai dengan protap IMD, dan pengawasan dilakukan oleh TIM RSSIB yaitu melakukan monitoring pelaksanaan program IMD di ruang VK. Dapat disimpulkan bidan belum mematuhi protap IMD sehingga perlunya diberikan motivasi kepada bidan pelaksana IMD agar bidan melaksanakan IMD sesuai dengan protap IMD dan evaluasi keseluruhan program IMD oleh Rumah Sakit Panti Wilasa Citarum Semarang
Analysis The Standard of Medical Record Resources Needed, Based on Workload at Ken Saras Hospital Medical Record Instalation 2013
Authors: Rosita Hasibuan Nelda , Kartika Wulan Lucia Ratna , Asmita Wigati Putri 
Published: September 2022

Background: Medical record has a purpose to achieve an orderly administrative in an increasing health effort. UU RI no. 29 of 2009 section 46 and 47 said that every doctor and dentist should be make an medical record in their practices. If they violate, they can be penalized accordance with the provisions. In this research, needs analysis seen from some aspect, the amount of resources, education, skill, and work motivation. Ken Saras Hospital Medical record installation suffer fairly high turnover in 2013, so it make increasingly heavy workload for the employees who still survive.Medical Records Installation in Ken Sarah Hospital has been regeneration at sometime ago, so it made heavy workload for resources who still survive. .The purpose of this research is to determine the workload of resources, the suitability of the workload and the need that based on workload. Method: This research used qualitative descriptive study with cross sectional approach. Data collection used work sampling method and in-depth interview. The population in the study was the time used medical record personnel in completing the work and the whole effort implementing IRM in a total of 11 people. Result: The results of this research is the ideal amount of medical record resources from amount of power aspect , education, skills and nowadays work motivation of resources. According the result of this research is 3.07 hours of workload, 3.3 hours of productive time, education, skill, and work motivation affect the work system of instalation. The workload in registration section is 5.88 hours, and 5.9 hours of productive time. Educational standards in irm is good enough, but need to add 1 resource in registration section with D3 RM standart. IRM skills is good enough, but need the training of medician recorder to improve the skill. Work motivation is still lacking. According this research, can be concluded that there's deficiency in medical record installation, 1-2 resources. The registration section with high school education competencies, need procurement training to improve the knowledge resources, and need some activities to improve work motivation
Morphological and molecular studies on the genus Gayralia (Ulotrichales, Chlorophyta) in northeastern Brazil with expansion of its species distribution
Authors: da Silva Sebastiana Lidielda Albuquerque , Brito Jhullyrson Osman Ferreira , Pereira Sonia Barreto , Gama Watson Arantes , José da Silva Junior Wilson , Benko-Iseppon Ana Maria , Cassano Valéria 
Published: September 2022

Abstract
The genus Gayralia has a complex taxonomy, often with morphological and ontogenetic characteristics that overlap with those of other monostromatic green algae, mainly Monostroma. Molecular studies of monostromatic green algae are still rare, especially in Brazil, where G. brasiliensis was described originally. Considering the difficulties in delimiting genera and species based on morphological criteria, we investigated the genus Gayralia through ITS sequencing of field collections in the tropical northeastern region of Brazil. Our 14 newly generated sequences formed a fully supported clade with G. brasiliensis showing low intraspecific divergence (0–0.6%). The distribution of G. brasiliensis in Brazil was expanded to the northeastern Brazilian coast, with the first record for the states of Rio Grande do Norte, Paraíba, Alagoas, and Sergipe. In addition, two sequences from India identified as G. “oxysperma” were grouped in the G. brasiliensis clade, indicating that they correspond to the same genetic species. This finding extends the geographical distribution of G. brasiliensis to India. Our results place Monostroma kuroshiense within the Gayralia clade, which warrants a new combination – Gayralia kuroshiensis (F.Bast) comb. nov.
Antioxidant and photocatalytic properties of zinc oxide nanoparticles phyto-fabricated using the aqueous leaf extract of Sida acuta
Authors: Ramesh Abhilash Mavinakere , Pal Kaushik , Kodandaram Anju , Manjula Bangalore Lakshminarayana , Ravishankar Doddarasinakere Kempaiah , Gowtham Hittanahallikoppal Gajendramurthy , Murali Mahadevamurthy , Rahdar Abbas , Kyzas George Z. 
Published: September 2022

Abstract
Nanoparticles have gained considerable attention during the present millennium due to its unique properties and usage of same in all the scientific fields. The present study was aimed to phyto-fabricate zinc oxide nanoparticles (ZnO NPs) from Sida acuta and evaluate its antioxidant and photocatalytic activity against the dye victoria blue (VB). The phyto-fabricated ZnO NPs when subjected for physico-chemical characterization showed an absorbance peak at 373 nm and was spherical in nature. Strong and well-distinguished sharp peaks were noticed in X-ray diffraction analysis with an average size of ∼32.82 nm calculated through Scherrer’s formula. The size was also authenticated through dynamic light scattering analysis and transmission electron microscopy. The Fourier transform-infrared spectroscopy confirmed that the phyto-constituents of the plant extract served as capping/stabilizing agents during the synthesis of ZnO NPs. The atomic force microscopy studies on morphology and geometrics of the synthesized particles indicated that particles were monodispersed with colour difference. In addition, the surface area of ZnO NPs measured by Braunauer–Emmett–Teller experimental studies for adsorption isotherms was found to be 7.364 m2·g−1. The antioxidant efficacy of the phyto-fabricated ZnO NPs offered concentration-dependent antioxidant activity with an IC50 value of 0.74 mg·mL−1. Further, the VB (9 mM) dye degradation studies using the phyto-fabricated ZnO NPs (0.75 g·L−1) resulted in dye degradation of 93% at 40 min in natural sunlight. Further, the reuse and recycling of the photocatalyst for dye degradation offered 70.25% dye degradation ability within 40 min exposure to sunlight at the fifth cycle of reusability thereby indicating effective dye degradation ability of the phyto-fabricated ZnO NPs from the aqueous leaf extract of S. acuta.
Computerized analysis of cardiotocograms in clinical practice and the SisPorto®system thirty-two years after: technological, physiopathological and clinical studies
Authors: Bernardes João 
Published: September 2022

AbstractObjectivesThe objective of this study is to present the why, what and how about computerized analysis of cardiotocograms (cCTG) and the SisPorto system for cCTG.ContentA narrative review about cCTG and the SisPorto system for cCTG is presented. The meta-analysis of randomized controlled trials (RCT) performed so far have evidenced that cCGT compared to traditional CTG analysis may save time spent in hospital for women, in the antepartum period, and is objective with at least equivalent results in maternal and perinatal outcomes, both in the ante and intrapartum periods. The SisPorto system for cCTG closely follows the FIGO guidelines for fetal monitoring. It may be used both in the ante and intrapartum periods, alone or connected to a central monitoring station, with simultaneous monitoring of fetal and maternal signals, not only in singletons but also in twins. It has been assessed in technical, physiopathological and clinical studies, namely in one large multicentric international RCT during labor and two meta-analysis.Summary and outlookThere is evidence that cCTG may be useful in clinical practice with advantages compared to traditional CTG analysis, although without clear impact on the decrease of preventable maternal and perinatal mortality and morbidity. More studies are warranted, namely on technical improvements and assessment in larger studies in a wider range of clinical settings.
Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy
Authors: Hsu Yu-Jen , Chern Yih-Jong , Lai I-Li , Chiang Sum-Fu , Liao Chun-Kai , Tsai Wen-Sy , Hung Hsin-Yuan , Hsieh Pao-Shiu , Yeh Chien-Yuh , Chiang Jy-Ming , Yu Yen-Lin , You Jeng-Fu 
Published: September 2022

Abstract
It is controversial whether patients who achieve clinical complete remission (cCR) of rectal cancer should be treated with the “watch and wait” (W&W) or radical resection (RR) strategy. Our study aimed to compare the survival outcomes and ostomy rate of the W&W and RR strategies. Between January 2008 and December 2015, we investigated 26 patients who achieved pathologic complete remission after undergoing RR and 36 patients who adopted the W&W strategy because of cCR. The tumor regrowth, salvage surgery, recurrence, disease-free, and overall survival (OS) rates were assessed. In our study, recurrences occurred in nine and two patients from the W&W and RR groups, respectively. Each patient in the RR group had a temporary or permanent ostomy, but only three (8.3%) had an ostomy in the W&W group. The 5-year recurrence rate was 25.0% in the W&W group and 7.7% in the RR group. Six patients (16.7%) had tumor regrowth in the W&W group, and all were resectable when regrowth. The 5-year OS rates between the two groups were nonsignificant. There is no specific risk factor for recurrence and OS. Under close surveillance, the W&W group achieved similar OS to the RR group and benefited from a lower ostomy rate.
Circadian clock and temporal meal pattern
Authors: Li Xin , Sun Zheng 
Published: September 2022

Abstract
The central circadian clock in the brain controls the time-of-the-day variations in acute meal responses, with a low glycemic response but a high satiety/thermogenic response to meals consumed at waking compared to other time points. Consistently, studies show that consuming a significant proportion of calories, particularly carbohydrates, in breakfast is beneficial for the chronic management of obesity and its associated metabolic syndrome, compared to consuming identical meals at dinner. Conversely, breakfast skipping or/and late dinner can have unfavorable metabolic outcomes. It remains controversial how meal frequency affects metabolic health. In contrast, irregular meals, especially irregular breakfasts, show consistent adverse metabolic consequences. Time-restricted feeding (TRF), with all calories consumed within less than 12-h per day, can improve metabolism and extend lifespan. A major component of TRF in humans is caloric restriction, which contributes significantly to the beneficial effects of TRF in humans. By comparison, TRF effects in rodents can be independent of caloric restriction and show day/night phase specificity. TRF could alleviate metabolic abnormalities due to circadian disruption, but its effects appear independent of the circadian clock in rodents. Understanding neuroendocrine mechanisms underlying clock-mediated metabolic regulation will shed light on the metabolic effects of temporal meal patterns.
Current and promising treatment strategies in glioma
Authors: Śledzińska Paulina , Bebyn Marek , Furtak Jacek , Koper Agnieszka , Koper Krzysztof 
Published: September 2022

Abstract
Gliomas are the most common primary central nervous system tumors; despite recent advances in diagnosis and treatment, glioma patients generally have a poor prognosis. Hence there is a clear need for improved therapeutic options. In recent years, significant effort has been made to investigate immunotherapy and precision oncology approaches. The review covers well-established strategies such as surgery, temozolomide, PCV, and mTOR inhibitors. Furthermore, it summarizes promising therapies: tumor treating fields, immune therapies, tyrosine kinases inhibitors, IDH(Isocitrate dehydrogenase)-targeted approaches, and others. While there are many promising treatment strategies, none fundamentally changed the management of glioma patients. However, we are still awaiting the outcome of ongoing trials, which have the potential to revolutionize the treatment of glioma.
The effect of tablet detergent wastewater using zeolite from rice husk ash on the chemical water quality and the growth of water hyacinth
Authors: Yusriadi Yusriadi , Ridayanti Dian , Sulastri Evi , Aanisah Nuur 
Published: September 2022

Abstract
The objective of this study is to determine the effect of detergent tablets containing zeolite from rice husk ash as builder on chemical water quality and growth of water hyacinth (Eichhornia crassipes). Water hyacinth is a plant that grows very readily in waters contaminated by detergent effluent, which can lead to eutrophication. Three detergent formulations were studied, differing only in their zeolite content: F1 (zeolite 15%), F2 (zeolite 20%) and F3 (zeolite 25%). The same formulations containing sodium tripolyphosphate (STTP) instead of zeolite were used for comparison: P1 (STTP 15%), P2 (STTP 20%) and P3 (STTP 25%). The effluents contained the respective formulations at five concentrations (0, 25, 50, 75, 100)%. Water hyacinth growth was studied by plant wet weight, plant height, number of leaves and dry weight, and water chemical parameters were determined by chemical oxygen demand (COD), biological oxygen demand (BOD), total suspended solid (TSS) and pH value. The results of the plant growth studies showed that detergent formulations F1 and F2 and comparative detergent formulations P1 and P2 caused plant growth. The measurements of BOD, COD, TSS and pH showed that the detergent formulation with zeolite had a higher value than the formulation of the comparison detergent. The formulation with a zeolite concentration of 25% (F3) is recommended because it is the best formula that has a negative effect on plant growth compared to formulations F1 and F2. This is supported by chemical parameters among which the COD, BOD and pH values still meet the requirements of the quality standards for detergent waste water.
Optimization of the primary purification process of extracting sphorolipid from the fermentation broth to achieve a higher yield and purity
Authors: Pal Yogita , Mali Suraj N. , Pratap Amit P. 
Published: September 2022

AbstractSophorolipid (SL) is a surface-active glycolipid biosurfactant with promising industrial applications. It is synthesised by fermentation of hydrophobic and hydrophilic substrates using selected non-pathogenic yeasts. However, its applications are limited by high production costs and ineffective product recovery in downstream purification stages. Natural sophorolipids are produced in six to nine different hydrophobic sophorosides, where the carboxyl end of the fatty acid is either free, which is known as the acidic or open form, or it can be esterified internally to produce the lactonic form. The present study deals with the screening and selection of suitable solvents for the extraction of acidic and lactonic SL from fermentation broth. The optimisation study involves exhaustive extraction with the six different immiscible solvents ethyl acetate, butyl acetate, methylene dichloride, methyltert.-butyl ether, methyliso-butyl ketone and methyl ethyl ketone. The partition coefficient (Kd), which is the ratio of the solute concentration in the organic layer compared to the aqueous layer, determines the performance measurement of the extraction process in terms of yield and purity of the desired solute. The factors that influence exhaustive extraction were the broth to solvent ratio and the extraction stages. The optimal extraction conditions for the highest possible yield were a broth to solvent ratio of 1:1 and a number of extraction steps of 2. Methylene dichloride showed better results in terms of yield and selectivity in the extraction of acidic and lactonic SL from the fermentation broth compared to the other solvents investigated. For lactonic SL, the highest Kdvalue determined was 36.6 and for acidic SL the highest Kdvalue was 1.14.
Rap1 prevents fusions between long telomeres in fission yeast
Authors: Pan Lili , Tormey Duncan , Bobon Nadine , Baumann Peter 
Published: September 2022

AbstractThe conserved Rap1 protein is part of the shelterin complex that plays critical roles in chromosome end protection and telomere length regulation. Previous studies have addressed how fission yeast Rap1 contributes to telomere length maintenance, but the mechanism by which the protein inhibits end fusions has remained elusive. Here, we use a mutagenesis screen in combination with high‐throughput sequencing to identify several amino acid positions in Rap1 that have key roles in end protection. Interestingly, mutations at these sites render cells susceptible to genome instability in a conditional manner, whereby longer telomeres are prone to undergoing end fusions, while telomeres within the normal length range are sufficiently protected. The protection of long telomeres is in part dependent on their nuclear envelope attachment mediated by the Rap1–Bqt4 interaction. Our data demonstrate that long telomeres represent a challenge for the maintenance of genome integrity, thereby providing an explanation for species‐specific upper limits on telomere length.
The OTUD6B‐LIN28B‐MYC axis determines the proliferative state in multiple myeloma
Authors: Paulmann Carmen , Spallek Ria , Karpiuk Oleksandra , Heider Michael , Schäffer Isabell , Zecha Jana , Klaeger Susan , Walzik Michaela , Öllinger Rupert , Engleitner Thomas , Wirth Matthias , Keller Ulrich , Krönke Jan , Rudelius Martina , Kossatz Susanne , Rad Roland , Kuster Bernhard , Bassermann Florian 
Published: September 2022

AbstractDeubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. Their inhibition can destabilize oncoproteins that may otherwise be undruggable. Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with dependency on the ubiquitin proteasome system and identified OTUD6B as an oncogene that drives the G1/S‐transition. LIN28B, a suppressor of microRNA biogenesis, is specified as a bona fide cell cycle‐specific substrate of OTUD6B. Stabilization of LIN28B drives MYC expression at G1/S, which in turn allows for rapid S‐phase entry. Silencing OTUD6B or LIN28B inhibits multiple myeloma outgrowth in vivo and high OTUD6B expression evolves in patients that progress to symptomatic multiple myeloma and results in an adverse outcome of the disease. Thus, we link proteolytic ubiquitylation with post‐transcriptional regulation and nominate OTUD6B as a potential mediator of the MGUS‐multiple myeloma transition, a central regulator of MYC, and an actionable vulnerability in multiple myeloma and other tumors with an activated OTUD6B‐LIN28B axis.