bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of sleep duration with underweight and obesity in older adults: A cross‐sectional study of the Chinese longitudinal healthy longevity survey
Authors: Zhao Xiaoguang , Yu Jiabin , Hu Fei , Chen Siyuan , Liu Nan 
Published: November 2022

AbstractObjectivesUnderweight and obesity are two of the main health concerns as they are associated with adverse health outcomes and nutrition disorders. This study determined the association of sleep duration with both underweight and obesity in Chinese older adults.MethodsThis cross‐sectional secondary data analysis was conducted using data from the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey. There were 13 917 participants aged 65 and above in the analysis. Body mass index (BMI) was categorized into underweight, normal weight and overweight, and obesity. Self‐reported sleep duration was divided into short, normal, and long sleep duration. Logistic regression models were used to examine the association of sleep duration with underweight and obesity.ResultsThe prevalence of underweight was 16.7% and the prevalence of obesity was 8.0% in Chinese older adults aged 65 and older. Compared to the normal sleep duration group, the short sleep duration group had a higher incidence of underweight (AOR = 1.29, 95% CI: 1.01–1.65), and the long sleep duration group showed a higher incidence of obesity (AOR = 1.57, 95% CI: 1.07–2.30) in older men. A greater incidence of underweight was found in the short sleep duration group (AOR = 1.19, 95% CI: 1.02–1.40) in old‐old adults after adjusting for covariates.ConclusionsShort sleep duration is associated with being underweight and long sleep duration is linked with obesity in older men. Short sleep duration is also a risk factor for the underweight of old‐old adults.
Synergistic effects of molybdenum disulfide on a novel intumescent flame retardant polyformaldehyde system
Authors: Yang Zheng , Kang Xinglong , Lu Shike , Wang Zhenhua , Fang Xiaomin , Li Jiantong , Liu Baoying , Ding Tao , Xu Yuanqing 
Published: November 2022

AbstractA novel intumescent flame retardant (IFR) composed of ammonium polyphosphate (APP), benzoxazine containing trialkoxysilane (BA‐a‐Si) and melamine (ME), is compounded with different specifications of MoS2 as synergist to flame retard polyformaldehyde (POM). The flame retardancy and mechanism of the composites are analyzed by limiting oxygen index (LOI), vertical combustion (UL‐94) and cone calorimeter. At the same time, the mechanical properties and lubricating properties are tested by electromechanical testing machine and wear testing machine. The experimental results show that MoS2 has a good synergistic effect with IFR, and the smaller the average particle size of MoS2 is, it seems to be more beneficial to improve the flame retardancy of POM composites. Only a small amount of MoS2 (0.8 wt%) is needed to synergize with IFR, the flame retardant POM composite (FR‐POM) can achieve UL‐94 (3.2 mm) V‐0 rating, LOI of 62.5%, and heat release rate reduction of 25.3%, total smoke release decreased by 29.5%. In addition, from the mechanical properties analysis, it is found that the microscale MoS2(M2) can better improve the bending and tensile properties of the FR‐POM composites, while the nanoscale MoS2(N80) is more helpful to improve the lubricating properties.
Collision‐free formation generation and tracking of unmanned aerial vehicles based on physicomimetics approach
Authors: Li Huiming , Chen Hao , Wang Xiangke 
Published: November 2022

AbstractThis paper investigates the problem of collision‐free leader–follower formation generation and tracking of multiple fixed‐wing unmanned aerial vehicles (UAVs). A group of UAVs, described by unicycle‐type models subject to velocity constraints, are required to form a desired formation, while tracking a virtual leader and achieving collision‐free flight. To handle this problem, a novel control law based on physicomimetics approach is proposed, which integrates the formation generation, formation tracking, and collision avoidance together. Physical forces are imitated to design artificial forces used in control laws that drive multiple UAVs to accomplish desired collaborative behaviors. Further, the virtual repulsion is embedded in the physicomimetics‐based control scheme to achieve obstacle avoidance naturally. The artificial forces have similar meaning to the physical forces because of similar forms, which facilitates the design and adjustment of the control strategy. Specially, to deal with the speed constraints of fixed‐wing UAVs, a saturation function is applied to modify the control laws and the stability is proved theoretically. Finally, numerical simulations and hardware‐in‐the‐loop experiments are provided to verify the effectiveness of the proposed control scheme.
Nichtlineare Ermittlung der Spannungszunahme im CFK‐Spannglied eines verbundlos vorgespannten Trägers
Authors: Raiyan Eman , Khorgade Prathamesh , Hückler Alex , Schlaich Mike 
Published: November 2022

AbstractDieser Beitrag befasst sich mit der nichtlinearen Ermittlung der Spannungszunahme in Spanngliedern aus carbonfaserverstärktem Kunststoff (CFK) in verbundlos vorgespannten Spannbetonträgern. Dafür wird zu Beginn ein Verfahren vorgeschlagen, anhand dessen die Spannungszunahme im Spannglied für jeden Lastschritt, vom Anfangszustand bis zum Bruchzustand, berechnet werden kann. Vom Anfangszustand bis zum Risszustand ist hierbei ein lineares Verfahren und vom Risszustand bis zum Bruchzustand ein iteratives Verfahren zielführend. Anschließend wird dieses Verfahren auf einen hypothetischen Spannbetonträger mit verbundlosen CFK‐Litzen angewendet. Die daraus resultierenden Ergebnisse werden anschließend mit zwei verfügbaren Normen verglichen. Die empirische Spannungszunahme gemäß DIN EN 1992‐1‐1 (EC2) liegt deutlich unterhalb des in der nichtlinearen Berechnung ermittelten Werts und führt zu einer unwirtschaftlichen Bemessung der kostspieligen Spannglieder. Die Berechnung nach der kanadischen Norm (CAN/CSA‐S806‐02) hingegen liegt um ca. 20 % oberhalb des Werts aus der eigenen Berechnung. Zuletzt wird im Rahmen einer Parameterstudie der Einfluss aus der Menge an schlaffer Bewehrung und Spannbewehrung auf die Spannungszunahme im CFK‐Spannglied untersucht. Die Ergebnisse zeigen, dass eine höhere Menge an Spannbewehrung die Spannungszunahme im Spannglied reduziert, während eine höhere Menge an schlaffer Bewehrung die Spannungszunahme erhöht.
Folic acid incorporated nitrogen‐doped carbon dots as a turn‐on fluorescence probe for homocysteine detection
Authors: Anju Saralammma Madanan , Aswathy Asokan Omana , Varghese Susan , Abraham Merin Kodinattumkunnel , Lekshmi Ragini Sanjeevan , Ibrahim Shkhair Ali , Lekha Girija Muraleedharan , Syamchand Sasidharanpillai S. , George Sony 
Published: November 2022

AbstractThis study describes the development of a low‐cost fluorescence assay for detecting homocysteine (Hcy) without the interference of cysteine and glutathione using carbon quantum dots. Herein nitrogen‐doped carbon quantum dots (NCDs) were synthesized from citric acid as the carbon source and urea as the dopant using a one‐pot microwave‐assisted method. The obtained NCDs were incorporated with folic acid (FA) by the direct ex situ addition method and were used as a fluorescence probe to detect Hcy. The probe exhibited a fluorescence turn‐on response with increased Hcy concentration up to 50 μM with a limit of detection of 2.276 μM. The point of care detection of Hcy using the probe was also tested with a paper‐based assay strip.
Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation
Authors: Watson Sara A. , Javanmardi Yousef , Zanieri Luca , Shahreza Somayeh , Ragazzini Roberta , Bonfanti Paola , Moeendarbary Emad 
Published: November 2022

AbstractThe human thymus is the site of T‐cell maturation and induction of central tolerance. Hematopoietic stem cell (HSC)‐derived progenitors are recruited to the thymus from the fetal liver during early prenatal development and from bone marrow at later stages and postnatal life. The mechanism by which HSCs are recruited to the thymus is poorly understood in humans, though mouse models have indicated the critical role of thymic stromal cells (TSC). Here, we developed a 3D microfluidic assay based on human cells to model HSC extravasation across the endothelium into the extracellular matrix. We found that the presence of human TSC consisting of cultured thymic epithelial cells (TEC) and interstitial cells (TIC) increases the HSC extravasation rates by 3‐fold. Strikingly, incorporating TEC or TIC alone is insufficient to perturb HSC extravasation rates. Furthermore, we identified complex gene expressions from interactions between endothelial cells, TEC and TIC modulates the HSCs extravasation. Our results suggest that comprehensive signaling from the complex thymic microenvironment is crucial for thymus seeding and that our system will allow manipulation of these signals with the potential to increase thymocyte migration in a therapeutic setting.
Worsened outcomes of newly diagnosed cancer in patients with recent emergency care visits: A retrospective cohort study of 3699 adults in a safety net health system
Authors: Pettit Nicholas R. , Li Xin , Stewart Lauren , Kline Jeffrey 
Published: November 2022

AbstractIntroductionMany patients receive a suspected diagnosis of cancer through an emergency department (ED) visit. Time to treatment for a new diagnosis of cancer is directly associated with improved outcomes with little no describing the ED utilization prior to the diagnosis of cancer. We hypothesize that patients that have an ED visit in proximity to a diagnosis of cancer will have worse outcomes, including mortality.MethodsThis study is a retrospective cohort study of all patients with cancer diagnosed at Eskenazi Health (Indiana) between 2016 and 2019. Individual health characteristics, ED utilization, cancer types, and mortality were studied. We compared those patients seen in the ED within 6 months prior to their diagnosis (cases) to patients not seen in the ED (controls).ResultsA total of 3699 patients with cancer were included, with 1239 cases (33.50%). Patients of black race had higher frequencies in the cases vs. controls (46.57% vs. 40.68%). Lung cancer was the most frequently observed cancer among cases vs. controls (11.70% vs. 5.57%). For the cases, 232 patients were deceased (18.72%) compared with 247 patients among the controls (10.04%,p < 0.0001, OR 2.06 95% confidence interval [CI] 1.70–2.51). An ED visit in past 6 months (OR = 1.73, 95% CI 1.38–2.18) and Medicaid insurance type (versus commercial, OR = 4.16, 95% CI 2.45–7.07) were associated with of mortality. Female gender (OR = 0.76, 95% CI 0.67–0.88), tobacco use (OR = 1.62, 95% CI 138–1.90), and Medicaid insurance type (versus commercial, OR = 2.56, 95% CI 2.07–3.47) were associated with prior ED use.ConclusionsOver one third of patients with cancer were seen in the ED within 6 months prior to their cancer diagnosis. Higher mortality rates were observed for those seen in the ED. Future studies are needed to investigate the association and impact that the ED has on eventual cancer diagnoses and outcomes.
Novel prognostic nomograms in cervical cancer based on analysis of 1075 patients
Authors: Rao Qunxian , Han Xue , Wei Yuan , Zhou Hui , Gong Yajie , Guan Meimei , Feng Xiaoyan , Lu Huaiwu , Chen Qingsong 
Published: November 2022

AbstractObjectiveTo explore the factors affecting the prognosis of cervical cancer (CC), and to construct and evaluate predictive nomograms to guide individualized clinical treatment.MethodsThe clinicopathological and follow‐up data of CC patients from June 2013 to December 2019 in Sun Yat‐sen Memorial Hospital of Sun Yat‐sen University were retrospectively analyzed. Log‐rank test was used for univariate survival analysis, and Cox multivariate regression was used to identify independent prognostic factors, based on which nomogram models were established and evaluated in multiple aspects.ResultsPatients were randomly assigned into the training (n = 746) and validation sets (n = 329). Survival analysis of the training set identified cervical myometrial invasion, parametrial involvement, and malignant tumor history as prognosticators of postoperative DFS and pathological type, cervical myometrial invasion, and history of STD for OS. C‐index was 0.799 and 0.839 for the nomograms for DFS and OS, respectively. Calibration curves and Brier scores also indicated high performance. Importantly, decision curve analysis suggested great clinical applicability of these nomograms.ConclusionsIn this study, we analyzed a cohort of 1075 CC patients and identified DFS‐ or OS‐associated clinicohistologic characteristics. Two nomograms were subsequently constructed for DFS and OS prognostication, respectively, and showed high performance in terms of discrimination, calibration, and clinical applicability. These models may facilitate individualized treatment and patient selection for clinical trials. Future investigations with larger cohorts and prospective designs are warranted for validating these prognostic models.
Daily practices in chemotherapy for advanced gastric or gastroesophageal junction adenocarcinoma: METESTOMAC French prospective cohort
Authors: Manfredi Sylvain , Dior Marie , Bouche Olivier , Barbier Emilie , Hautefeuille Vincent , Guillet Marielle , Turpin Justine , Bourgeois Vincent , Helene Dall Osto , Desgrippes Romain , Audemar Franck , Molin Yann , Locher Christophe , Chatellier Thierry , Lecomte Thierry , Baize Nathalie , Lecaille Cedric , Spaeth Dominique , Goujon Gael , Lepage Come , Tougeron David ,   For The Metestomac Investigators/Collaborators
Published: November 2022

AbstractBackgroundAround 50% of gastric cancers are diagnosed at an advanced stage. Several chemotherapy regimens are now internationally validated. Few data are available on the routine daily management of advanced gastric or gastroesophageal junction cancers. We aimed to describe chemotherapy practices, tolerance, and efficacy overall survival (OS) and Progression free survival (PFS) in a prospective French cohort.MethodsPatients starting palliative chemotherapy were prospectively enrolled in 49 French centres. The primary objective was to report and describe patients' characteristics and treatment strategies. Secondary objectives were OS, PFS, objective response rate, adverse events rate, performance status deterioration during the chemotherapy.ResultsA total of 182 patients were included; 179 were analysed. Most patients received platinium‐based chemotherapy as the first treatment and FOLFIRI as second; 62.0% of patients received a second line, and 32.4% a third line. More than two thirds of Her2‐positive patients were first treated with trastuzumab. The FOLFIRI regimen was the most frequently used second‐line therapy. Median OS was 13.3 months, similar whatever the chemotherapy or combinations used in the first line. One‐ and 2‐year OS increased with the number of chemotherapy lines received, from respectively 24.7% and 5.7% (1 line), to 46.9% and 12.4% (2 lines) and 88.1% and 29.9% (3 or more lines) (p < 0.0001).ConclusionOur study showed that treatment strategies in France are based on a succession of doublets, making it possible to offer a second and third line of treatment more often. This treatment strategy must be taken into account for future trials with immunotherapy combinations.
Real‐life challenges using personalized prognostic scoring systems in acute myeloid leukemia
Authors: Calleja Anne , Loschi Michael , Bailly Laurent , Morisot Adeline , Marceau Alice , Mannone Lionel , Robert Guillaume , Auberger Patrick , Preudhomme Claude , Raynaud Sophie , Subtil Fabien , Sujobert Pierre , Cluzeau Thomas 
Published: November 2022

AbstractPersonalized medicine is a challenge for patients with acute myeloid leukemia (AML). The identification of several genetic mutations in several AML trials led to the creation of a personalized prognostic scoring algorithm known as the Knowledge Bank (KB). In this study, we assessed the prognostic value of this algorithm on a cohort of 167 real life AML patients. We compared KB predicted outcomes to real‐life outcomes. For patients younger than 60‐year‐old, OS was similar in favorable and intermediate ELN risk category. However, KB algorithm failed to predict OS for younger patients in the adverse ELN risk category and for patients older than 60 years old in the favorable ELN risk category. These discrepancies may be explained by the emergence of several new therapeutic options as well as the improvement of allogeneic stem cell transplantation (aHSCT) outcomes and supportive cares. Personalized medicine is a major challenge and predictions models are powerful tools to predict patient's outcome. However, the addition of new therapeutic options in the field of AML requires a prospective validation of these scoring systems to include recent therapeutic innovations.
Effect of client‐centred therapy on the coping strategies of sexually harassed students in tertiary institutions in Taraba State, Nigeria
Authors: Matsayi Lucy Aji , Adamu Naomi Nuhu , Kefas Vivian Azumi , Menchak Clifford Yubsih 
Published: November 2022

AbsractThis study examined the effects of client‐centred therapy (CCT) on the coping strategies of sexually harassed students in tertiary institutions in Taraba State, Nigeria. It also looked for any gender differences in the effect of CCT on the coping strategies of sexually harassed students. We employed a quasi‐experimental and pretest–post‐test design with control group. The statistical population comprised 250 students who had experienced sexual harassment in tertiary institutions, of which 20 students were selected using convenience sampling. The students who had been sexually harassed were then randomly assigned to the experimental and control groups. The experimental group subsequently underwent six 60‐min sessions of CCT, while the control group received placebo treatment on drug abuse. The research tools included a sexual harassment battery (SHB). Inferential statistics of analysis of covariance (ANCOVA) was used to analyse the data. Cronbach's alpha produced a reliability coefficient of 0.79 for the SHB. The following findings were recorded: (i) client‐centred therapy effectively increased the coping strategies of students and (ii) there was no significant mean difference between male and female students in the effectiveness of CCT on coping strategies.
Primary hyperparathyroidism in the geriatric population: A case report and mini literature review
Authors: Jaisinghani Priya , Sharma Anupa , Wang Xiangbang 
Published: November 2022

AbstractWe report a case of a 93‐year‐old woman with PHPT secondary to a left inferior parathyroid adenoma. The patient met criteria to be a surgical candidate; however, literature about parathyroidectomy in the elderly was limited and controversial. The patient remained stable through medical management for the next 5 years.
A cranial approach to transplastron coeliotomy and gastrotomy performed in a Sri Lanka Black Turtle (Melanochelys trijuga thermalis): Case Report
Authors: Gamage Bope Gamage Sashikala Sewwandi , Perera Bulathge Vijitha Pushpakumara , Sumanasekera Kashmini Kaushalya , Samarakoon Kalani Piyumika , Abeywardhane Vithana Pathirannehalage Malaka Kasun , Silva‐Fletcher Ayona 
Published: November 2022

AbstractSuccessful transplastron coeliotomy via a temporary cranial plastron osteotomy can be conducted in turtles to remove foreign bodies lodged in the stomach, using basic equipment. A year later, the turtle was returned to the wild indicating that major surgeries with complete recovery can be achieved in this species.
Staphylococcal scalded skin syndrome in adults with obesity and type 2 diabetes: A case series
Authors: Vitale Carolina , Spinozzi Valentina , Colangeli Luca , Sbraccia Paolo , Guglielmi Valeria 
Published: November 2022

AbstractStaphylococcal scalded skin syndrome (SSSS) primarily affects children and rarely adults with immunodepression. We describe two cases of adults diagnosed with SSSS with no additional cause of immunological compromise other than obesity and uncontrolled diabetes. An increased risk of infection should be considered in cases of obesity and diabetes.
Multi‐objective firefly algorithm with multi‐strategy integration
Authors: Lv Li , Zhou Xiaodong , Tan Dekun , Kang Ping , Wu Runxiu 
Published: November 2022

SummaryIn the optimization process of multi‐objective firefly algorithm, population is easy to fall into local optimum, which leads to poor population distribution and convergence. In order to solve this problem, this article proposes a multi‐objective firefly algorithm with multi‐strategy integration (MOFA‐MSI). First, in order to improve the distribution of population, MOFA‐MSI proposes a cloning strategy, which calculates the distribution degree of individuals in population, clones them according to their distribution degree, and local mutation in the cloned individual produce a new population with good distribution. Then, in order to maintain the convergence of population, a position updating strategy based on non‐dominated sorting is proposed. The new population after local mutation are performed by non‐dominated sorting, and the fireflies with higher rank guide the fireflies with lower rank to fly, and then new population are generated by global mutation after position updated. Finally, the greedy strategy is adopted to select solutions with better distribution and convergence and store them in external files. In the experimental part, different types of test problems are used to test the performance of each algorithm, and MOFA‐MSI is compared with three classical and four new multi‐objective evolutionary algorithms. The results show that MOFA‐MSI is superior to other seven algorithms in terms of the distribution and convergence of population.
Privacy‐preserving enhanced dummy‐generation technique for location‐based services
Authors: Parmar Dilay , Rao Udai Pratap 
Published: November 2022

SummaryLocation‐based services (LBS) has become an intrinsic part of our everyday life. However, the flexibility and convenience provided by LBS are at the cost of user privacy since untrusted LBS server can leak private information of users. To overcome the privacy issues observed in LBS, a novel dummy‐generation based privacy preservation technique is proposed in this article. The proposed dummy‐generation technique is a circle‐based technique which generates dummy locations in the circle area and is effective against center‐of‐anonymized spatial region attack, map‐matching attack, and location‐homogeneity attack. Additionally, an edge computing enabled framework is proposed, which can be used in the IoT environment. The edge computing enabled framework helps in handling the resource poverty issues of the service requesting devices and provides the low latency solution. The security analysis of our proposed dummy‐generation technique reflects that the proposed technique is resilient to specific attacks for different adversary attack models. The results obtained through simulations suggest that our technique performs better than the pre‐existing techniques.