bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Flexible Metal–Organic Framework Based on a Tailorable Mn8‐Cluster Showing Smart Responsiveness to Aromatic Guests and Capacity for Gas Separation
Authors: Wang Wei , Xiong Xiao‐Hong , Zhu Neng‐Xiu , Zeng Zheng , Wei Zhang‐Wen , Pan Mei , Fenske Dieter , Jiang Ji‐Jun , Su Cheng‐Yong 
Published: March 2022

AbstractThe design and creation of soft porous crystals combining regularity and flexibility may promote potential applications for gas storage and separation due to their deformable framework's responsiveness to external stimuli. The flexibility of metal–organic frameworks (MOFs) relies on alterable degrees of freedom that are mainly provided by organic linkers or the junctions linking organic and inorganic building units. Herein, we report a new dynamic MOF whose flexibility originates from an unprecedented tailorable Mn8O38‐cluster and shows simultaneous coordination geometry changes and ligand migration that are reversibly driven by guest exchange. This provides an extra degree of freedom to the framework's deformation, resulting in three‐dimensional variations in the framework that subtly respond to varied aromatic molecules. The gas adsorption behavior of this flexible MOF was evaluated, and the selective separation of light hydrocarbons and Freon gases is achieved.
Synthesis and Characterization of Poly(5’‐hexyloxy‐1’,4‐biphenyl)‐b‐poly(2’,4’‐bispropoxysulfonate‐1’,4‐biphenyl) with High Ion Exchange Capacity for Proton Exchange Membrane Fuel Cell Applications
Authors: Jin Kunyu , Yue Baohua , Yan Liuming , Qiao Risa , Zhao Hongbin , Zhang Jiujun 
Published: March 2022

AbstractProton exchange membrane (PEM) is pivotal for proton exchange membrane fuel cells (PEMFCs). In the present work, a block copolymer with hydrophilic alkyl sulfonated side groups and hydrophobic flexible alkyl ether side groups, poly(5’‐hexyloxy‐1’,4‐biphenyl)‐b‐poly(2’,4’‐bispropoxysulfonate‐1’,4‐biphenyl) (HBP‐b‐xBPSBP), is designed and synthesized by copolymerization of the hydrophilic and hydrophobic oligomers. The oligomers are synthesized via a Pd‐catalyzed Suzuki cross‐coupling of 1,3‐dibromo‐5‐hexyloxybenzene, and 3,3’‐[(4,6‐dibromo‐1,3‐phenylene)bis(oxy)]bis(propane‐1‐sulfonate) or 1,4‐bis(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)benzene. The good solubility and film‐forming characteristics are achieved via the introduction of flexible hexyloxy side groups, and high ion exchange capacity (IEC) is achieved via the introduction of high density of alkyl sulfonated side groups. The HBP‐b‐0.5BPSBP has the highest IEC of 3.17 mmol/g, the highest proton conductivity of 43.5 mS/cm at 95 °C and 90% relative humidity (RH) and low methanol permeability of 6.45×10−7 cm2/s. Meanwhile, crosslinked HBP‐b‐xBPSBP exhibits promising water uptake, swelling ratio and low methanol permeability. These characteristics are attributed to the crosslinked structure and the hydrophilic/hydrophobic nanophase separation morphology promoted by the poly(m‐phenylene) main chains, flexible alkyl ether groups, and alkyl sulfonated side groups.
Manganese‐based materials as cathode for rechargeable aqueous zinc‐ion batteries
Authors: Guo Yixuan , Zhang Yixiang , Lu Hongbin 
Published: March 2022

AbstractRechargeable aqueous zinc‐ion batteries (ZIBs) are promising candidates for advanced electrical energy storage systems owing to low cost, intrinsic safety, environmental benignity, and decent energy densities. Currently, significant research efforts are being made to develop high‐performance positive electrodes for ZIBs. Nevertheless, there are still many obstacles to be overcome in pursuit of the comprehensive performance of cathode materials, including specific capacity, structural stability, rate performance, and so forth. Many manganese‐based compounds have become the hotspots in the study of ZIB cathodes due to their advantages of natural abundance, less toxicity, and high operating voltage. Here, different energy storage mechanisms of various kinds of manganese‐based compounds are summarized. Electrochemical results of manganese‐based cathodes are compared and analyzed. Moreover, optimization strategies for addressing existing issues of these materials and improving ZIBs are discussed in detail.
Engineering tumor constructs to study matrix‐dependent angiogenic signaling of breast cancer cells
Authors: Nasser Malak , Ghosh Gargi 
Published: March 2022

AbstractBreast cancer is the leading cause of cancer deaths among females globally. The crosstalk between tumor microenvironment and neoplastic cells is the key for promoting tumor growth, stimulating tumor angiogenesis, and metastasis to distant organs. Thus, it is highly important to investigate tumor cell–matrix interactions to facilitate screening of different anti‐cancer agents, individually or in combination. We, herein report, the development of an in vitro three‐dimensional (3D) breast cancer model to investigate the effect of stromal crosslinking and consequent, stiffening on the angiogenic activity of cancer cells. Crosslinking of collagen gels was altered via non‐enzymatic glycation and highly aggressive breast cancer cells, MDA‐MB‐231, were encapsulated in these gels. Cells encapsulated in glycated/stiffer matrices displayed an increased expression of pro‐angiogenesis‐related signals. Inhibition of mechanotransduction pathways on the angiogenic activity of aggressive tumor cells in stiff matrices was investigated using Y‐27632, blebbistatin, and cytochalasin D. Rho‐associated kinase (ROCK) inhibitor, Y‐27632, diminished the pro‐angiogenic signaling, thereby suggesting the potential dependence of breast cancer cells on the Rho/ROCK pathway in regulating tumor angiogenesis. Our findings highlight the potential of the developed model to be used as a tool to investigate matrix‐associated tumor angiogenesis and screen different therapeutic agents towards inhibiting it.
Relationship between perioperative oncological evaluation and recurrence using circulating tumor DNA with KRAS mutation in patients with colorectal cancer
Authors: Hayashi Takaomi , Yoshida Yoichiro , Yamada Teppei , Tanaka Keita , Shimaoka Hideki , Kajitani Ryuji , Munechika Taro , Nagano Hideki , Matsumoto Yoshiko , Komono Akira , Sakamoto Ryohei , Aisu Naoya , Yoshimatsu Gumpei , Yoshimura Fumihiro , Hasegawa Suguru 
Published: March 2022

AbstractBackgroundThe detection of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) by liquid biopsy may have prognostic information. In this perioperative study, we evaluate if there is a relationship between mutant allele frequency (MAF) of Kirsten rat sarcoma viral oncogene homolog (KRAS) and tumor recurrence and how that could be useful in the early detection of recurrence.MethodsAmong 304 cases of colorectal cancer surgery, ctDNA was sampled from the perioperative blood of 84 patients with CRC with KRAS mutation (exon 4 p.A146T, exon 4 p.A146V, exon 2 p.G12A, exon 2 p.G12C, exon 2 p.G12D, exon 2 p.G12S, exon 2 p.G12V, exon 2 p.G13D, exon 3 p.Q61H) and analyzed using the digital polymerase chain reaction system. The median observation period was 26 months.ResultsAlthough the relationship between the perioperative MAF of KRAS and recurrence was not proved, tumor diameter, tumor depth, and stage were correlated with the preoperative MAF of KRAS (p = 0.034, p = 0.002, p = 0.008). However, tumor diameter, tumor depth, and stage did not correlate with MAF of KRAS at postoperative day 30.ConclusionsIn this study, pathological tumor size, tumor depth, and stage were correlated with preoperative MAF of KRAS, but it was unreliable to predict recurrence by detection of ctDNA with KRAS mutation in the perioperative period of colorectal surgery.
Elevated air quality index and fine particulate matter levels contribute to the poor prognosis and progression of nonsmall‐cell lung cancer: A cohort study combined with external validation
Authors: Li Jing , Wei Xiaoying , Gu Ling , Qiu Linya , Xiang Mengqi , Zhang Huachuan , Xia Lei , Pan Wenying , Yang Zhenyu , Zhou Xiaoli , Zeng Daxiong , Jiang Junhong 
Published: March 2022

AbstractBackgroundPoor air quality can result in a variety of respiratory disorders. However, the air quality index (AQI) and the level of fine particulate matter (PM2.5) on the progression and prognosis of nonsmall‐cell lung cancer (NSCLC) are unclear.MethodsWe launched a cohort study focused on the relationship between air quality and overall survival as well as progression, incorporating data from 590 patients with NSCLC in our medical center between November 1, 2013 and March 1, 2016. Forty‐nine patients from Sichuan Cancer Hospital were used for validation.ResultsCases with poorer AQI 6 months before NSCLC diagnosis were more likely to progress to stage III to IV NSCLC than controls (OR = 2.61, 95% CI 1.35–5.24, p = 0.005). Similarly, if exposed to high levels of PM2.5 during these 6 months, overall survival was poor (HR [95% CI] = 1.53 [1.13, 2.07], p = 0.006). According to multivariate analysis, age, gender, KPS, PM2.5, hyperlipemia, and NSCLC stage were independent risk factors of overall survival. A predictive model developed by these factors above yielded a favorable agreement (C‐index = 0.758) on the calibration curve. External validation was conducted by 46 patients from Sichuan Cancer Hospital displaying an AUC of 0.724 (0.684–0.763).ConclusionsPM2.5 and AQI levels affect disease progression and long‐term survival in NSCLC patients. An overall survival prediction model based on the PM2.5 level can help clinicians predict the risk of death in NSCLC.
Evaluation of Two Water Deficit Models on Phenolic Profiles and Antioxidant Activities of Different Peach Fruits Parts
Authors: Guizani Monia , Dabbou Samia , Maatallah Samira , Montevecchi Giuseppe , Antonelli Andrea , Serrano Maria , Hajlaoui Hichem , Rezig Mourad , Kilani‐Jaziri Soumaya 
Published: March 2022

AbstractThe present work was designed to evaluate the effects of two water shortage strategies on the phenolic profile and antioxidants activities of four Prunus persica L. cultivars (Flordastar, Early May crest, Rubirich and O'Henry). Over the course of two successive seasons (2016 and 2017), three different irrigation strategies were tested: full irrigation (FI: 100 % crop evapotranspiration (Etc)), sustained deficit irrigation (SDI: 50 % ETc), and cyclic deficit irrigation (CDI: irrigation at 100 % field capacity with a soil moisture of 50 % field capacity). HPLC‐UV/VIS profile of phenolic compounds, enzymatic and non‐enzymatic antioxidant activities were assessed in exocarp and mesocarp. The results showed that deficit irrigation improved the content of phenolic compounds and the antioxidant activities. In O'Henry, ascorbate peroxidase activity increased significantly under CDI in exocarp (249 %). In conclusion, most cultivars showed an improvement of the fruit quality under SDI, whereas O'Henry fruits gathered the highest phenolic amounts and displayed the best antioxidant activity under CDI.
Chemodiversity, Biological Activities and Molecular Docking Studies ofLeptadenia pyrotechnica(Forssk.) Decne: A Comprehensive Approach to Validate Its Medicinal Use.
Authors: Zubair Momina , Nazir Mamona , Saleem Muhammad , Raiz Naheed , Touseef Saba , Khan Saima , Zengin Gokhan , Ehsan Mazhar Muhammad , Imran Tousif Muhammad 
Published: March 2022

AbstractLeptadenia pyrotechnica(Forssk.) Decne is growing in Cholistan desert, and is known for its laxative, analgesic, anabolic and astringent, antioxidant, anti‐inflammatory, antibacterial, antitumor, hypolipidemic and antiatherosclerotic properties. The present study disclosed the metabolic picture ofL. pyrotechnicaand validates its folk uses. LP‐H fraction constitute 25.79±0.11 mgGAE/g extract and 20.64±0.33 mgRE/g extract of phenolic and flavonoid content, respectively, followed by LP‐E (23.15±0.33 mgGAE/g extract and 19.40±0.13 mgRE/g extract), however, LP‐E exhibited the highest free radical scavenging (DPPH: 21.05±0.45mgTE/g and ABTS: 68.12±0.53 mgTE/g) and metal reducing (FRAP: 44.93±1.66, CUPRAC: 117.42±1.28 mgTE/g, respectively) activities. The total antioxidant capacity in Phosphomolybdenum assay (1.52±0.14 mmolTE/g) and ferrous ion chelating (11.57±0.29 mgEDTAE/g) activities were observed highest for LP‐H extract. In cholinesterase's inhibitory assays, the LP‐E and LP‐W extracts exhibited inhibitory values as 2.43 and 2.40±0.07 mgGALAE/g extract, respectively against AChE, while against BChE the LP‐H displayed the highest value as 5.98±0.44 mgGALAE/g extract. The LP‐H fraction also showed the highest inhibition potential (7.72±0.14 mmol ACAE/g and 0.55±0.01 mmol ACAE/g, respectively) against α‐glucosidase and α‐amylase enzymes, while, in tyrosinase inhibitory assay, all the fractions exhibited significant activities in the range of 59.35±0.29 to 55.18±0.49 mgKAE/g extract. RP‐UHPLC/MS analysis of LP‐M disclosed the presence of 57 metabolites of various classes. A multivariate analysis and molecular docking study was also carried out to establish relationships between the metabolites and the biological activities, which finally validate the use ofL. pyrotechnicaas herbal medicine or component nutraceutical, food and cosmetic industry.
Conformationally Constrained Sialyl Analogues as New Potential Binders of h‐CD22
Authors: Forgione Rosa Ester , Nieto Ferran Fabregat , Di Carluccio Cristina , Milanesi Francesco , Fruscella Martina , Papi Francesco , Nativi Cristina , Molinaro Antonio , Palladino Pasquale , Scarano Simona , Minunni Maria , Montefiori Marco , Civera Monica , Sattin Sara , Francesconi Oscar , Marchetti Roberta , Silipo Alba 
Published: March 2022

AbstractHere, two conformationally constrained sialyl analogues were synthesized and characterized in their interaction with the inhibitory Siglec, human CD22 (h‐CD22). An orthogonal approach, including biophysical assays (SPR and fluorescence), ligand‐based NMR techniques, and molecular modelling, was employed to disentangle the interaction mechanisms at a molecular level. The results showed that the Sialyl‐TnThr antigen analogue represents a promising scaffold for the design of novel h‐CD22 inhibitors. Our findings also suggest that the introduction of a biphenyl moiety at position 9 of the sialic acid hampers canonical accommodation of the ligand in the protein binding pocket, even though the affinity with respect to the natural ligand is increased. Our results address the search for novel modifications of the Neu5Ac‐α(2‐6)‐Gal epitope, outline new insights for the design and synthesis of high‐affinity h‐CD22 ligands, and offer novel prospects for therapeutic intervention to prevent autoimmune diseases and B‐cell malignancies.
Dexmedetomidine attenuates hypoxia‐induced cardiomyocyte injury by promoting telomere/telomerase activity: Possible involvement of ERK1/2‐Nrf2 signaling pathway
Authors: Wu Wei , Du Zhen , Wu Lei 
Published: March 2022

AbstractDexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, possesses cardioprotection against ischemic/hypoxic injury, but the exact mechanism is not fully elucidated. Since telomere/telomerase dysfunction is involved in myocardial ischemic damage, the present study aimed to investigate whether Dex ameliorates cobalt chloride (CoCl2; a hypoxia mimic agent in vitro)‐induced the damage of H9c2 cardiomyocytes by improving telomere/telomerase dysfunction and further explored the underlying mechanism focusing on extracellular signal‐regulated kinase (ERK1/2)‐NF‐E2‐related factor 2 (Nrf2) signaling pathway. The result showed that Dex increased cell viability, decreased apoptosis, and reduced cardiomyocyte hypertrophy as illustrated by the decreases in cell surface area and the biomarker levels for cardiac hypertrophy including atrial natriuretic peptide, brain natriuretic peptide, and myosin heavy chain β messenger RNA (mRNA) and protein in CoCl2‐exposed H9c2 cells. Intriguingly, Dex increased the telomere length and telomerase activity as well as telomere reverse transcriptase protein and mRNA levels in H9c2 cells exposed to CoCl2, indicating that Dex promotes telomere/telomerase function under hypoxia. In addition, Dex remarkably diminished the reactive oxygen species generation, reduced malondialdehyde content, and increased antioxidative signaling as evidenced by the increases in superoxide dismutase and plasma glutathione peroxidase activities. Furthermore, Dex increased the ratio of P‐ERK1/2/T‐ERK1/2 and P‐Nrf2/T‐Nrf2 and enhanced Nrf2 nuclear translocation in CoCl2‐subjected H9c2 cells, suggesting that Dex promotes the activation of the ERK1/2‐Nrf2 signaling pathway. These novel findings indicated that Dex attenuates myocardial ischemic damage and reduces myocardial hypertrophy by promoting telomere/telomerase function, which may be associated with the activation of the ERK1/2‐Nrf2 signaling pathway in vitro.
Mitral valve edge‐to‐edge repair versus indirect mitral valve annuloplasty in atrial functional mitral regurgitation
Authors: Rottländer Dennis , Golabkesh Milad , Degen Hubertus , Ögütcü Alev , Saal Martin , Haude Michael 
Published: March 2022

AbstractObjectivesWe aimed to compare indirect mitral annuloplasty using the Carillon Mitral Contour System and edge‐to‐edge repair via MitraClip in atrial functional mitral regurgitation (aFMR).BackgroundIn patients with left ventricular dilation, both edge‐to‐edge repair and indirect mitral annuloplasty are effective in reducing mitral regurgitation, while no clinical trial has compared both interventional methods in aFMR.MethodsIn a retrospective single‐center analysis, 41 patients with aFMR underwent either edge‐to‐edge mitral valve repair (MitraClip group, n = 20) or indirect annuloplasty (Carillon group, n = 21).ResultsBoth treatment groups showed high procedural success (100%) and low complication rates. Both treatment groups showed a comparable reduction of New York Heart Association (NYHA) classification postimplantation, after 3‐ and 12‐months follow‐up. Quantitative reduction in echocardiographic FMR parameters was significantly pronounced in the MitraClip group (reduction in vena contracta MitraClip vs. Carillon: postimplantation −74.6 ± 25.8 vs. −29.1 ± 17.8%, 3‐months follow‐up −65.8 ± 31.2 vs. −33.9 ± 17.5%, 12‐months follow‐up −50.8 ± 27.9 vs. −23.9 ± 17.0%, p < 0.05). Qualitative mitral valve assessment showed improved FMR class postimplantation, at 3‐and 12‐months follow‐up in both treatment groups. Edge‐to‐edge repair revealed better results with lower average FMR classification compared to indirect coronary sinus‐based annuloplasty. After 12‐months left atrial (LA) volume was significantly reduced in the Carillon group, while in the MitraClip group no LA remodeling was found (reduction in LA volume MitraClip vs. Carillon at 12 months: +9.6 ± 25.1% vs. −12.3 ± 12.7%, p < 0.05).ConclusionsBoth indirect mitral valve annuloplasty and edge‐to‐edge repair are feasible and safe in patients with aFMR, while the reduction in FMR was pronounced in the edge‐to‐edge repair group.
Contrast‐Induced encephalopathy following diagnostic coronary angiography
Authors: Rashid Hytham , Brown Jonathan , Nix Emily , Fisher Covin Alan 
Published: March 2022

AbstractContrast‐induced encephalopathy (CIE) is a rare, reversible complication of coronary angiography that can mimic acute strokes. This case illustrates the diagnostic challenges for a patient presenting with confusion following coronary angiography and raises awareness for CIE as diagnosis of exclusion.
Durable Electrooxidation of Acidic Water Catalysed by a Cobalt‐Bismuth‐based Oxide Composite: An Unexpected Role of the F‐doped SnO2 Substrate
Authors: Du Hoang‐Long , Chatti Manjunath , Kerr Brittany , Nguyen Cuong K. , Tran‐Phu Thanh , Hoogeveen Dijon A. , Cherepanov Pavel V. , Chesman Anthony S. R. , Johannessen Bernt , Tricoli Antonio , Hocking Rosalie K. , MacFarlane Douglas R. , Simonov Alexandr N. 
Published: March 2022

AbstractAiming to design a catalyst for stable electrooxidation of water at low pH, the present work explores the properties and structural features of electrodeposited composite oxides based on Bi and Co, which were anticipated to provide stability and catalytical activity, respectively. Materials deposited as very thin (ca 50 nm) films on F‐doped SnO2 (FTO) substrate do not initially exhibit high activity in 0.1 M H2SO4, but are activated during operation through the electrooxidatively‐induced enrichment of the catalytic surface with Co and Sn oxides. The latter originate from the FTO support and are identified as an important component of the catalyst through control experiments with a Sn‐free substrate and with Sn2+ intentionally added at the electrodeposition stage. A distinctive feature of the Co−Bi−Sn‐based electrocatalyst is the slow but persistent improvement in the activity during operation in 0.1 M H2SO4 at both ambient and elevated (60 °C) temperatures, which contrasts with the continuously degrading behaviour of state‐of‐the‐art oxygen evolution catalysts at low pH. This is demonstrated by 9‐day‐long galvanostatic tests at 10 mA cm−2, during which the Co−Bi−Sn‐based thin film catalyst shows no degradation and sustains stable water oxidation at ca 1.9 V vs. reversible hydrogen electrode. The effects of tin leaching from the support detected herein might have implications to other acidic water oxidation catalysts supported on high‐surface area doped SnO2 materials.
Polysulfide Synthesis Using Waste Cooking Palm Oil via Inverse Vulcanization
Authors: Nayeem Abdullah , Ali Mohd Faizal , Shariffuddin Jun Haslinda 
Published: March 2022

AbstractElemental sulfur and waste cooking palm oil (WCO) are abundant industrial by‐products from petrochemical and food processing industries, respectively. WCO was used as a crosslinker to prepare a high‐sulfur‐content polymer through inverse vulcanization. Polysulfides were generated under vigorous stirring of WCO with elemental sulfur at different temperatures, crosslinking ratios, and reaction times. The physicochemical properties of the produced polysulfides were determined and the thermal stability was analyzed. The FTIR spectra including the breakdown of C=C and formation of C–S bond confirmed the change of functional groups between WCO and produced polymer. The effect of saturated and unsaturated triglycerides of WCO is clearly visible in SEM micrographs. The polysulfide with a 70 wt % sulfur feed ratio showed excellent morphological and thermal properties.