bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Value of Heart Rate and Blood Pressure on the Prognosis of Postural Tachycardia Syndrome in Children
Authors: Wang Shuo , Zou Runmei , Cai Hong , Wang Cheng 
Published: March 2022

BackgroundTo investigate the predictive value of heart rate (HR) and blood pressure (BP) on the prognosis of postural tachycardia syndrome (POTS) in children.Materials and Methods53 cases of children aged 5 to 15 years who visited in the Pediatric Syncope Specialist Clinic of The Second Xiangya Hospital of Central South University for unexplained syncope or syncope precursor were diagnosed with POTS by head-up tilt test (HUTT) as the POTS group. 38 healthy children aged 5 to 16 years who underwent physical examination at the Child Health Care Clinic of the hospital in the same period were matched as controls (control group). The children with POTS were followed up after 3 months of treatment and were divided into good prognosis group (40 cases) and poor prognosis group (13 cases) according to the results of HUTT re-examination and whether the symptoms improved or not. HR and BP indicators were collected from each group at baseline and during HUTT.ResultsThere were 91 research subjects, of which 45 are males, with a mean age of 11.52 ± 2.13 years. (1) HR at 5 and 10 min (HR 5 and HR 10, respectively), HR difference at 5 and 10 min (HRD 5 and HRD 10, respectively), and HR and BP product at 5 and 10 min (RPP 5 and RPP 10, respectively) were greater in the POTS group than in the control group (P &lt; 0.01). (2) HR 5, HR 10, HRD 5, HRD 10, and RPP 10 in children with POTS were smaller in the good prognosis group than the poor prognosis group (P &lt; 0.01). (3) The area under curve was 0.925 on the four combined indicators (HR 5, HR 10, HRD 5, and HRD 10), predicting a good prognosis of POTS, sensitivity of 99.99%, and specificity of 75.00%.ConclusionsHR 5, HR 10, HRD 5, HRD 10, and RPP 10 and the four combined indicators (HR 5, HR 10, HRD 5, and HRD 10) had predictive value for the POTS prognosis in children. The predictive value of the four combined indicators for the POTS prognosis was better than that of the single HR 5, HRD 5, and RPP 10.
A de novo Non-sense Nuclear Factor I B Mutation (p.Tyr290*) Is Responsible for Brain Malformation and Lung Lobulation Defects
Authors: Huang Hao , Jin Jieyuan , Wu Liping , Wu Huifen , Pi Huichun , Dong Yi , Xiang Rong 
Published: March 2022

BackgroundNuclear factor I B (NFIB) plays an important role in regulating the transcription of multiple biological processes. Mutations in NFIB cause intellectual disability and macrocephaly. However, studies on abnormal brain and lung development caused by NFIB mutations are lacking.MethodsIn the present study, we enrolled a fetus with brain malformation and lung lobulation defects from China. Whole-exome sequencing (WES) was performed to detect the candidate genes and Sanger sequencing was performed for mutational analysis.ResultsAfter data filtering and bioinformatics prediction, a novel non-sense mutation of NFIB (NM_001190737:c.870C &gt; A;p.Tyr290*) was identified in the fetus. This variant was predicted to produce a truncated NFIB protein because of a premature stop codon and was absent in 200 healthy controls.ConclusionTo the best of our knowledge, this is the first case of brain malformation and lung lobulation defects caused by a NFIB variant in Asia. These findings contribute to genetic diagnosis and family counseling and expand our understanding of NFIB mutations as well as brain and lung maturation.
Enhanced RAGE Expression and Excess Reactive-Oxygen Species Production Mediates Rho Kinase-Dependent Detrusor Overactivity After Methylglyoxal Exposure
Authors: Oliveira Akila L. , Medeiros Matheus L. , de Oliveira Mariana G. , Teixeira Caio Jordão , Mónica Fabíola Z. , Antunes Edson 
Published: March 2022

Methylglyoxal (MGO) is a highly reactive dicarbonyl compound implicated in diabetes-associated diseases. In vascular tissues, MGO induces the formation of advanced glycation end products (AGEs) that bounds its receptor RAGE, initiating the downstream tissue injury. Outside the cardiovascular system, MGO intake produces mouse voiding dysfunction and bladder overactivity. We have sought that MGO-induced bladder overactivity is due to activation of AGE-RAGE-reactive-oxygen species (ROS) signaling cascade, leading to Rho kinase activation. Therefore, female mice received 0.5% MGO orally for 12 weeks, after which in vitro bladder contractions were evaluated in the presence or not of superoxide dismutase (PEG-SOD) or the Rho kinase inhibitor Y27632. Treatment with MGO significantly elevated the serum levels of MGO and fluorescent AGEs, as well as the RAGE immunostaining in the urothelium, detrusor, and vascular endothelium. RAGE mRNA expression in the bladder was also higher in the MGO group. Methylglyoxal significantly increased the ROS production in both urothelium and detrusor smooth muscle, with the increases in detrusor markedly higher than urothelium. The bladder activity of superoxide dismutase (SOD) was significantly reduced in the MGO group. Gene expressions of L-type Ca2+ channels, RhoA, ROCK-1, and ROCK-2 in bladder tissues were significantly elevated in the MGO group. Increased bladder contractions to electrical-field stimulation, carbachol α,β-methylene ATP, and extracellular Ca2+ were observed after MGO exposure, which was significantly reduced by prior incubation with either PEG-SOD or Y27632. Overall, our data indicate serum MGO accumulation elevates the AGEs levels and activates the RAGE-ROS signaling leading to Rho kinase-induced muscle sensitization, ultimately leading to detrusor overactivity.
Fluidic-Based Instruments for Space Biology Research in CubeSats
Authors: Harandi Bijan , Ng Simon , Liddell Lauren C. , Gentry Diana M. , Santa Maria Sergio R. 
Published: March 2022

For the last 15 years, small satellites known as CubeSats have been used to investigate the effects of the space environment on biological organisms. All biological CubeSat missions flown to date have performed studies in low Earth orbit (LEO), each one improving its biological support sub-systems from the last. An upcoming NASA biological CubeSat mission, BioSentinel, will launch as a secondary payload on Artemis 1 and eventually reach a heliocentric orbit beyond LEO, and the protection of Earth’s magnetosphere. The main objectives of BioSentinel are 1) to investigate the biological effects of the deep space radiation environment and 2) to develop our technological capacity to support biological research in deep space. The instruments and subsystems within BioSentinel have heritage from previous CubeSat missions (e.g., fluidics, optics, thermal control), but are extended on many levels. BioSentinel improves upon the materials and design (e.g., decreased card vapor permeability to maintain low humidity; the addition of a fluidic manifold with internal check-valves, desiccant chambers, and bubble traps for each individual fluidic card) and adds new tools for discovery (e.g., onboard LET spectrometer). The main objective of this Perspective is to emphasize the evolution of the fluidic systems used in past and ongoing NASA biological CubeSat missions and highlight aspects of these systems that can be optimized for future experimentation beyond LEO.
Adapted Fencing for Patients With Invasive Breast Cancer: The RIPOSTE Pilot Randomized Controlled Trial
Authors: Omorou Abdou Y. , Peiffert Didier , Rotonda Christine , Van Hoye Aurélie , Allado Edem , Hily Oriane , Temperelli Margaux , Chenuel Bruno , Hornus-Dragne Dominique , Poussel Mathias 
Published: March 2022

IntroductionEven if indications for mastectomy have been progressively reduced in loco-regional breast cancer (BC) treatment, the harmful effects of surgery are still numerous and can impact physical and psychological wellbeing of women. The RIPOSTE (Reconstruction, self-Image, Posture, Oncology, “Santé”-Health, Therapy, “Escrime”-Fencing) program aimed to propose adapted fencing to patients with BC. This study aims to investigate the effect and conditions of effectiveness of the RIPOSTE program.Methods and analysisThis is a prospective randomized controlled trial including 24 patients with invasive BC who have just undergone surgery. The study will be proposed to the patient and if interested, the patient will be referred to a sports physician for a medico-sportive evaluation. At the end the evaluation, if the patient meets the inclusion criteria, she will be randomly assigned to one of the 2 groups based on a 1:1 principle: Early RIPOSTE group (receive one fencing session per week for 3 months immediately after their inclusion), Delayed RIPOSTE group (receive one fencing session per week for 3 months but within the 3 months following their inclusion). Patients will be included for 6 months with 3 follow-up times (0, 3, and 6 months) by a sport physician. The primary outcome is the evolution of quality of life score. Secondary outcomes are disability score, fatigue, anxiety-depression, cost-effectiveness and process evaluation.Ethics and disseminationThe study protocol has been approved by a French ethics committee (CPP Sud Méditerranée IV, N°ID-RCB: 2020-A01916-33). Results will be submitted for publication, at scientific conferences and through press releases.Trial RegistrationNCT04627714.
INTERACTION OF THE GLOBAL MARKET OF EDUCATIONAL SERVICES AND THE HIGHER EDUCATION SYSTEM OF UKRAINE
Authors: BOLSHAIA O. , KUZMENKO H. , DIACHENKO-BOHUN M. 
Published: March 2022

Interaction between the global market of educational services and the higher education system of Ukraine
Statement of the problem and its connection with important scientific and practical tasks.
The article examines the functioning of the global market of educational services and the main trends of its development. We also consider the peculiarities of Ukrainian educational reform and mechanisms that ensure the growth of competitiveness of domestic institutions of higher education in the world market of educational services.
The author emphasizes that the creation of socio-economic preconditions for the development and formation of the national system of higher education in the global dimension relies on both the state and the institution itself. Progress relies on the development of cooperation between educational institutions and European universities in order to achieve a higher level of development of educational innovative technologies. An important factor for the accelerated processes of growth and integration into the global educational community is the process of academic mobility, which includes both teachers and students. This process takes a person to another level of communication and beyond his cultural and scientific traditions. Thus, the process of entrusting the achievements of world culture and education. Integration into the global educational space is a guarantee of improving the quality and competitiveness of higher education in Ukraine.
CONTINUITY PRINCIPLE REALIZATION OF FOREIGN LANGUAGE TEACHING IN THE CONTEXT OF PRESCHOOL AND PRIMARY EDUCATION REFORMATION
Authors: PALEHA O. 
Published: March 2022

The paper is devoted to the study of the principle of continuity implementation between preschool and primary education in the process of a child’s foreign language communicative competence formation. The paper aims to analyze various aspects of the principle of continuity implementation in the process of foreign language learning in the preschool educational institution and primary school.
The author considers different approaches to the interpretation of the category ‘continuity.’ The paper emphasizes that continuity is considered as a pedagogical principle, general pedagogical regularity, methodological principle, or didactic principle.
The article analyzes the features of the various aspects of continuity implementation. The target aspect of continuity is realized in the definition of a common goal for children’s foreign language communicative competence formation. It is proved that the principle of continuity in the target aspect of foreign language learning is observed in preschool educational institutions and primary school as the learning process, which is aimed at forming elements of preschool children’s linguistic and speech competencies.
It has been found that the semantic aspect of continuity is reflected in common topics for communication (‘I, my family and friends,’ ‘Nature,’ ‘Holidays’) and language inventory. The importance of play activities in teaching a foreign language to children of preschool and primary school age is revealed. It is stated that the pervasive nature of play activities in the process of learning a foreign language ensures the continuity of the child’s foreign language communicative competence formation, as play is a leading activity in preschool and retains its importance along with learning activities in primary school.
Combined Preparation Cratal in Therapy of Cardiovascular Diseases
Authors: Бабушкина А.В. 
Published: March 2022

Статья содержит информацию о комбинированном препарате Кратал, созданном на основе растительного сырья – густых экстрактов пустырника и плодов боярышника – и компонента с метаболическим действием таурина. Подробно рассматриваются механизмы действия каждого компонента препарата. Представлены результаты доклинического изучения специфической фармакологической активности Кратала и данные его клинических исследований.The article contains information on the combined preparation Cratal created on the base of vegetative raw material – motherwort herb and hawthorn fruits dense extracts and a component with metabolic action of taurine. Mechanisms of action of the preparation components are considered in detail. There are presented the results of preclinical study of specific pharmacological activity of Cratal and the data of its clinical study.
Pengembangan Lokasi Agroindustri Buah-Buahan Di Kabupaten Indramayu Jawa Barat
Authors: Juswadi Juri , Sumarna Pandu 
Published: March 2022

The aim this research is to plan the location development of fruit agroindustry in Indramayu Regency. The Identification of the fruit agroindustry location is based on the cost efficiency of fruit supplies transportation as raw materials, which are produced by 31 sub-districts. In this development plan, Indramayu district is divided into four regions based on the closesness of the location and the production of mango, banana, papaya, guava, watermelon, and sapodilla. The determination of the agro-industry location is based on the center of gravity method. Research data on fruit production is taken from the Central Bureau of Statistics of Indramayu Regency. The location data of each district was obtained from google maps. The results of data analysis show that the mango agroindustry location development is located at Terusan-Sindang village in Region I, Arjasari-Patrol village in Region II, Tanjung Kerta-Kroya village in Region III and Tambi Lor-Sliyeg village in Region IV. The development of banana argoindustry location is located in Bojangsari-Indramayu village in Region I, Bongas-Bongas village in Region II, Gantar-Gantar village in Region III and Cangkingan-Kedokanbunder village in Region IV. The Development of Papaya agroindustry location is found in Karanganyar-Indramayu village in Region I, Kertamulya-Bongas village in Region II, Kroya-Kroya village in Region III and Pilangsari-Jatibarang village in Region IV. The guava agroindustry location development is found in Karangmalang- Indramayu village in Region I, Cipaat-Bongas village in Region II, Mekarjati-Haurgeulis village in Region III and Bulak-Jatibarang village in Region IV. The development of watermelon agrioindustry location is situated in Karanganyar-Indramayu village in Region I, Jatimunggul-Terisi village in Region III and Jayalaksana- Kedokanbunder village in Region IV. The development of sapodilla agroindustry location is in Karangmalang- Indramayu village in Region I, Lempuyang-Anjatan village in Region II, Sumbon-Kroya village in Region III and Tambi Lor-Sliyeg village in Region IV.
EL SENDERO LOMADAS DE LA AGUADA Y SU USO MILENARIO EN LA QUEBRADA DE EL TALA, VALLE CENTRAL DE CATAMARCA
Authors: Caraffini Claudio Caraffini , Fonseca Ezequiel Fonseca , Melian Cristian Melian , Puentes Hugo Puentes 
Published: March 2022

Entendemos al espacio que vincula el Sendero de Las Lomadas de La Aguada en la Quebrada de El Tala desde la geografía crítica como una expresión material de un paisaje construido a lo largo del tiempo con usos que dan cuenta de la larga historia de resignificación de este paisaje y de su importancia en la memoria de las generaciones que lo han transitado, donde un conjunto de formas producidas por acciones sociales generaron transformaciones tanto de los sujetos como del entorno. Por ello, en este artículo daremos cuenta de las diversas formas de usos que tuvo y tiene el paisaje de la Quebrada de El Tala, tomando el sendero de las Lomadas de la Aguada como un espacio que dio lugar a formas específicas de organización del espacio y el tiempo en el valle de Catamarca. Este sendero fue una vía de acceso obligada entre las ocupaciones humanas conectando el valle de Catamarca, la Quebrada de El Tala y las márgenes superiores del Cordón montañoso del Ambato durante casi dos milenios, se lo asocia a numerosos sitios prehispánicos del Periodo Formativo hasta la conquista. Los españoles lo transitaron desde 1595, como vía de acceso a la sierra de Ambato. A fines del siglo XIX se lo mejora para provisionarse de materiales para construcción en la ciudad, hacia mediados del siglo XX cae en desuso como vía de comunicación y, finalmente, su reutilización en el siglo XXI cobró nuevamente importancia como espacios vividos, espacios creados, espacios transitados y sobre todo espacios culturales donde su significación en su valor histórico y cultural cobra importancia.
On the issue of obtaining platelet-rich plasma
Authors: Bazlov S. B. , Melkonian K. I. , Rusinova T. V. , Popandopulo K. I. , Marchenko N. V. , Shevchuk D. D. 
Published: March 2022

Objective: To determine the optimal technological modes for the preparation of platelet-rich plasma (PRP) using standard laboratory equipment.Material and methods: Blood for the research was taken from 25 healthy volunteers. Its centrifugation was performed on a standard CM-6M laboratory centrifuge using various modes and two types of vacuum tubes with lithium heparin containing separation gel and without it. The number of platelets and leukocytes was calculated in the upper, lower and middle layers of the obtained plasma sample.Results: Plasma samples obtained during centrifugation modes from 415 to 1660 g for 10 minutes using test tubes that do not contain separation gel are optimal in terms of the number of platelets. Plasma intake from the lower layer of the obtained sample after centrifugation is always accompanied by the inclusion of leukocytes in its composition, which can lead to undesirable tissue reactions when it is used.Conclusion: To obtain PRP, it is possible to use standard laboratory equipment in the centrifugation mode from 415 to 1660 g for 10 minutes using test tubes that do not contain separation gel. Plasma sampling for clinical use should be carried out from the middle layer of the obtained sample.
Experience in the treatment of spinal tumors complicated by compression of the spinal cord and its roots
Authors: Kit O. I. , Zakondyrin D. E. , Grin A. A. , Rostorguev E. E. , Yundin S. V. 
Published: March 2022

Objective: Improvement of the results of treatment of vertebral tumors with neural compression by means of analyzing the authors’ experience.Material and methods: The study included 151 patients with primary and metastatic vertebral tumors, operated in the neurosurgical departments of three large medical institutions from 01.01.2014 to 31.12.2020.Results: Most of the patients underwent palliative interventions. Radical surgery (marginal or wide resection of the tumor) was performed in 8 (5%) patients. Surgical treatment as the only method of treatment was used in 75 (50%) cases, combined treatment was used in 42 (28%) people, complex treatment – in 34 (22%). The immediate results of treatment of 91% of patients were characterized by the absence of negative dynamics in the neurological status and in 50% of cases by positive dynamics in the functional state. Among patients with malignant tumors and a traced catamnesis, the one-year survival rate was 66%, three-year – 52%, five-year – 47%. The median overall survival rate was 12.8 months, the median event-free survival rate was 12.55 months.Conclusion: The use of non-radical interventions in the surgery of vertebral tumors with neural compression expands the possibilities of minimizing surgical trauma, while maintaining the neurological and improving the functional status of the patient.
Istota i znaczenie Ćwiczeń duchowych św. Ignacego Loyoli dla rozwoju duchowego chrześcijanina
Authors: Królikowski SJ Wacław 
Published: March 2022

CEL NAUKOWY: Celem naukowym niniejszego artykułu jest przedstawienie istoty Ćwiczeń duchowych św. Ignacego Loyoli, ich realizacji w rekolekcjach ignacjańskich oraz ukazanie ich znaczenia dla życia duchowego chrześcijanina.
PROBLEM I METODY BADAWCZE: Problemem badawczym rozpatrywanym w niniejszym artykule jest poszukiwanie odpowiedzi na pytanie: na czym polega istota Ćwiczeń duchowych i jakie jest ich znaczenie dla rozwoju życia duchowego chrześcijanina? W przeprowadzonych badaniach zastosowano metodę analizy i syntezy literatury.
PROCES WYWODU: W pierwszej części artykułu został przybliżony bezpośredni związek pomiędzy nawróceniem Ignacego, przeżyciem przez niego wielu łask mistycznych, szczególnie w Manresie, a powstaniem książeczki Ćwiczeń duchowych. W drugiej części artykułu przedstawione zostały fragmenty świadectw rekolektantów, którzy dzięki metodzie i treści Ćwiczeń duchowych pogłębili swoje życie duchowe.
WYNIKI ANALIZY NAUKOWEJ: Rezultatem badań jest zarówno opis procesu nawrócenia Ignacego Loyoli mającego bezpośredni wpływ na powstanie Ćwiczeń duchowych, które stały się powszechnym narzędziem pomocnym do rozwoju duchowego wielu chrześcijan. Świadectwem tego są wypowiedzi uczestników rekolekcji ignacjańskich reprezentujących różne grupy społeczne i różne profesje, którzy przeżyli wewnętrzną przemianę dzięki Ćwiczeniom duchowym św. Ignacego Loyoli.
WNIOSKI, INNOWACJE, REKOMENDACJE: Świadectwa rekolektantów zarówno tych sprzed wieków, jak i dzisiejszych potwierdzają, że Ćwiczenia duchowe św. Ignacego Loyoli stanowią ważne narzędzie rozwoju duchowego. Choć powstały prawie pięć wieków temu jako owoc duchowych przeżyć ich Autora, nadal wychowują chrześcijan do coraz głębszej relacji z Bogiem.