bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Challenges of Eating Well for People Living with Cystic Fibrosis: an Interview Study Exploring the Use of Mindful Eating Approaches and Behaviours to Support Optimal Nutritional Status
Authors: Egan Helen , Keyte Rebecca , Mantzios Michail 
Published: January 2022

AbstractBackgroundNutritional status and weight are closely linked to lung function and health status in cystic fibrosis (CF). The investigation of eating behaviours has shown mindfulness practices to be useful in modifying eating behaviours, particularly with obesity; to date, no research specifically explores how these concepts may be utilised within a CF population who face specific challenges in eating behaviours.MethodAdult patients (n = 20,M = 8, age range 21–62 years) were recruited from a UK CF regional centre to take part in qualitative semi-structured interviews. Experiences of eating behaviours focusing on the use of mindful (or mindless) eating as barriers and enablers to achieving and maintaining optimal nutritional status were explored. Data were analysed using thematic analysis with a contextualist approach to understand how participants experienced eating behaviours within the context of health and weight status.ResultsParticipants engaged readily in discussions of eating behaviour describing active self-regulation of food eaten and calorie intake. Participants who struggled to maintain weight employed strategies to increase calorie intake such as distraction and multitasking while eating. Most participants reported no pleasure in food, describing eating as another treatment to endure. Confusion existed around how to eat healthily for CF alongside co-morbid health conditions including diabetes, cholesterol and heart disease.ConclusionParticipants were highly aware of their eating behaviours, engaging in intentional and deliberate preparations, which could be described as mindful, for making eating a more automatic or mindless activity. Modifications to usual mindful eating interventions are needed to support people with CF.
Composition of volatile compounds in male and female Tenebrio molitor and Leptinotarsa decemlineata before and after the application of insecticides
Authors: Wojciechowska Marta , Stepnowski Piotr , Gołębiowski Marek 
Published: January 2022

AbstractSome insects can be used as food, while others can affect the destruction of crops and the reduction of food reserves. The studies described in this article showed quantitative and qualitative changes in the composition of volatile compounds contained in adult Tenebrio molitor and Leptinotarsa decemlineata insects after applying insecticides. The samples were prepared by SPME and the final determinations were carried out by GC/MS. The volatile compounds that were present only in the insects after the application of insecticides (or in a larger quantities) could be due to the insecticides, as an insect defense response to these insecticides. For example, in adult T. molitor insects, the percentage of alkanes ranged from 38.63 to 59.05% (male), and from 38.89% to 60.20 (female), depending on the insecticide used and the time elapsed since its application. In contrast, in L. decemlineata, the percentage of alkanes ranged from 43.84 to 61.85% (female), and from 42.41 to 60.11% (male). The results of the present study can be useful in understanding the i defense strategies of insects against insecticides.
Pesticide-free agriculture as a new paradigm for research
Authors: Jacquet Florence , Jeuffroy Marie-Hélène , Jouan Julia , Le Cadre Edith , Litrico Isabelle , Malausa Thibaut , Reboud Xavier , Huyghe Christian 
Published: January 2022

AbstractReducing pesticide use has become a goal shared by several European countries and a major issue in public policies due to the negative impacts of pesticides on the environment and on human health. However, since most of the agri-food sector relies on pesticides in these countries, substantially reducing pesticide use is a complex issue. To overcome this situation, we argue that agricultural research has a major role to play and must adopt a pesticide-free paradigm to expect a deep impact on pesticide use. In this article, we explain why this new paradigm is needed and outline research fronts that it will help address. These research fronts are related to five strategies: (1) redesigning cropping systems to enhance prophylaxis, (2) diversifying biocontrol strategies and associated business models, (3) broadening the scope of plant breeding to include functional biodiversity and evolutionary ecology concepts, (4) setting new goals for agricultural machinery and digital technologies, and (5) supporting development of public policies and private initiatives for the transition toward pesticide-free agri-food systems. The corresponding research activities must be managed conjointly to develop systemic and coupled innovations, which are essential for reducing pesticide use significantly. We therefore provide examples of cross-cutting objectives that combine these fronts while also highlighting the need for interdisciplinary research projects. By doing so, we provide an overall orientation for research to achieve sustainable agriculture.
Putting “Heavy” into Heavy Slow Resistance
Authors: Morrison Scot , Cook Jill 
Published: January 2022

AbstractThe body of literature on tendinopathy management has come a long way in the last few decades and a variety of changes in the clinical approach have emerged from this research. One particular approach that shows promise has been called “heavy slow resistance” (HSR), and this has been the subject of investigation in a number of randomized controlled trials. While the premise for this approach is defensible, a critical examination of the implementation of these HSR protocols results in some concerns when compared to basic exercise science principles. This article lays out some considerations that will help future investigators to improve their exercise prescription approaches in this area.
Russian Innovation in the Era of Patent Globalization
Authors: Lebedenko Svitlana 
Published: January 2022

AbstractThe launch of the Russian Sputnik vaccine in 2020 echoed the launch of the Soviet Sputnik satellite in 1957 and reminded the world once again that Russia is a sophisticated technological power. Most inventions in the Soviet Union were managed by the system of inventor’s certificates which ensured open flows of knowledge among the scientific networks behind Russia’s industrial development. Inventions in today’s Russia are managed by the globalized institution of patents which can create high barriers to entry in innovation markets. This article argues that the globalized institution of patents has been compromised in Russia because the barriers to entry that patents create are not justified in the absence of well-functioning markets. The danger of the institutional mismatch is lost opportunities for Russia to grow knowledge and to diversify its economy. Western property rights in innovation in the hands of crony capitalists can magnify the social harms of the patent system leading to high concentration of ownership of knowledge.
Applications of Unsupervised Machine Learning in Autism Spectrum Disorder Research: a Review
Authors: Parlett-Pelleriti Chelsea M. , Stevens Elizabeth , Dixon Dennis , Linstead Erik J. 
Published: January 2022

AbstractLarge amounts of autism spectrum disorder (ASD) data is created through hospitals, therapy centers, and mobile applications; however, much of this rich data does not have pre-existing classes or labels. Large amounts of data—both genetic and behavioral—that are collected as part of scientific studies or a part of treatment can provide a deeper, more nuanced insight into both diagnosis and treatment of ASD. This paper reviews 43 papers using unsupervised machine learning in ASD, including k-means clustering, hierarchical clustering, model-based clustering, and self-organizing maps. The aim of this review is to provide a survey of the current uses of unsupervised machine learning in ASD research and provide insight into the types of questions being answered with these methods.
Longitudinal white matter hyperintensity changes and cognitive decline in patients with minor stroke
Authors: Jiang Jingwen , Yao Kanmin , Huang Xiaojun , Zhang Yu , Shen Fanxia , Weng Suiqing 
Published: January 2022

Abstract
Background and objective
As reported, both minor stroke and white matter hyperintensities (WMHs) are associated with an increased risk of cognitive impairment and dementia. The underlying factors for dynamic changes in WMH volume and cognitive performances in patients with minor stroke remain poorly understood. A 2-year longitudinal study was designed to investigate the factors associated with the changes in white matter hyperintensity (WMH) volume on brain MRI and cognitive decline in patients with minor stroke.

Methods
A group of eligible patients with minor ischemic stroke was recruited in a row. At the initial and 2-year follow-up visits, all the participants underwent routine examinations, multimodal MRI, and cognitive assessment. Using a lesion prediction algorithm tool, we were able to automate the measurement of the change in WMH volume. During the 2-year follow-up, cognitive function was evaluated using Telephone Interview for Cognitive Status-Modified (TICS-m). Participants’ demographic, clinical, and therapeutic data were collected and statistically analyzed. Regression analyses were used to test the relationships between risk factors and changes in WMH volume and cognitive decline.

Results
Finally, we followed up with 225/261 participants for 2 years, with a mean age of 65.67 ± 10.73 years (65.6% men). WMH volume was observed to be increased in 113 patients, decreased in 74 patients, and remained stable in 58 patients. Patients with WMH progression were more often had a history of hypertension (p = 0.006) and a higher CSVD burden both at baseline and follow-up visit (p < 0.05). Longitudinally, the proportion of patients taking antihypertension medications on a regular basis in the regression group was higher than in the stable group (p = 0.01). When compared to the stable group, the presence of lacunes (OR 9.931, 95% CI 1.597–61.77, p = 0.014) was a stronger predictor of progression in WMH volume. 87 subjects (38.6%) displayed incident cognitive impairment. The progression of WMH volume was a significant risk factor for cognitive decline (p < 0.001).

Conclusions
The longitudinal change of WMH is dynamic. The regressive WMH volume was associated with the use of antihypertensive medications on a regular basis. The presence of lacunes at the initial visit of the study was a stronger predictor of WMH progression. The progression of WMH volume could be useful in predicting cognitive decline in patients with minor stroke.
Recycled materials in railroad substructure: an energy perspective
Authors: Indraratna Buddhima , Qi Yujie , Malisetty Rakesh Sai , Navaratnarajah Sinniah K. , Mehmood Fatima , Tawk Miriam 
Published: January 2022

AbstractGiven that the current ballasted tracks in Australia may not be able to support faster and significantly heavier freight trains as planned for the future, the imminent need for innovative and sustainable ballasted tracks for transport infrastructure is crucial. Over the past two decades, a number of studies have been conducted by the researchers of Transport Research Centre (TRC) at the University of Technology Sydney (UTS) to investigate the ability of recycled rubber mats, as well as waste tyre cells and granulated rubber to improve the stability of track substructure including ballast and subballast layers. This paper reviews four applications of these novel methods, including using recycled rubber products such as CWRC mixtures (i.e., mixtures of coal wash (CW) and rubber crumbs (RC)) and SEAL mixtures (i.e., mixtures of steel furnace slag, CW and RC) to replace subballast/capping materials, tyre cells reinforcements for subballast/capping layer and under ballast mats; and investigates the energy dissipation capacity for each application based on small-scale cyclic triaxial tests and large-scale track model tests. It has been found that the inclusion of these rubber products increases the energy dissipation effect of the track, hence reducing the ballast degradation efficiently and increasing the track stability. Moreover, a rheological model is also proposed to investigate the effect of different rubber inclusions on their efficiency to reduce the transient motion of rail track under dynamic loading. The outcomes elucidated in this paper will lead to a better understanding of the performance of ballast tracks upgraded with resilient rubber products, while promoting environmentally sustainable and more affordable ballasted tracks for greater passenger comfort and increased safety.
Restoration of enamel anti-wear properties via remineralization: Role of occlusal loading
Authors: Peng Jiapin , Lei Lei , Xiao Heng , Yang Dan , Zheng Jing , Zhou Zhongrong 
Published: January 2022

AbstractIn this in vitro study, the restoration of acid-eroded enamel surface morphology and anti-wear properties under two conditions, mono-remineralization (treated with remineralization alone) and impact-remineralization (treated with cyclic impact followed by remineralization), are characterized to determine the effect of occlusal loading on enamel remineralization. Compared with the mono-remineralized surface, the impact-remineralized surface demonstrates better anti-wear performance, as manifested by a higher hardness and elastic modulus, as well as a lower friction coefficient and wear volume. Loading on the eroded enamel surface induces the fragmentation of hydroxyapatite nanoparticles, which aids crystal deposition and fusion during subsequent remineralization. In summary, owing to the enamel microstructure, occlusal loading can promote the restoration of enamel anti-wear properties by enhancing remineralization. Remineralization enhancement through occlusal-loading-induced nanoparticle fragmentation plays a significant role in preventing human teeth from excessive wear.
Humoral immunogenicity and tolerability of heterologous ChAd/BNT compared with homologous BNT/BNT and ChAd/ChAd SARS-CoV-2 vaccination in hemodialysis patients
Authors: Haase Michael , Lesny Paul , Anderson Mark , Cloherty Gavin , Stec Michael , Haase-Fielitz Anja , Haarhaus Mathias , Santos-Araújo Carla , Veiga Pedro Mota , Macario Fernando 
Published: January 2022

Abstract
Background
After the reports of severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine, patients who had received one dose of ChAdOx1-S-nCoV-19 vaccine were recommended a second dose of Pfizer’s BNT162b2 vaccine. In hemodialysis patients, we compared the humoral immunogenicity and tolerability of homologous vaccination with ChAdOx1-nCoV-19/ChAdOx1-nCoV-19 (ChAd/ChAd) and BNT162b2/BNT162b2 (BNT/BNT) with heterologous vaccination of first dose of ChAdOx1-nCoV-19 and a second dose with BNT162b2 (ChAd/BNT).

Methods
In a multicenter prospective observational study, SARS-CoV-2 spike-IgG antibody levels, Nucleocapsid-protein-IgG-antibodies, and vaccine tolerability were assessed 6 weeks after second SARS-CoV-2 vaccination in 137 hemodialysis patients and 24 immunocompetent medical personnel.

Results
In COVID-19-naïve hemodialysis patients, significantly higher median SARS-CoV-2-spike IgG levels were found after ChAd/BNT (N = 16) compared to BNT/BNT (N = 100) or ChAd/ChAd (N = 10) (1744 [25th–75th percentile 276–2840] BAU/mL versus 361 [25th–75th percentile 120–936] BAU/mL; p = 0.009; 1744 [25th–75th percentile 276–2840] BAU/mL versus 100 [25th–75th percentile 41–346] BAU/mL; p = 0.017, respectively). Vaccinated, COVID-19-naïve medical personnel had median SARS-CoV-2 spike-IgG levels of 650 (25th–75th percentile 217–1402) BAU/mL and vaccinated hemodialysis patients with prior COVID-19 7047 (25th–75th percentile 685–10,794) BAU/mL (N = 11). In multivariable regression analysis, heterologous vaccination (ChAd/BNT) of COVID-19-naïve hemodialysis patients was independently associated with SARS-CoV-2 spike-IgG levels. The first dose of ChAd and the second dose of BNT after the first vaccination with ChAd (heterologous vaccination, ChAd/BNT) were associated with more frequent but manageable side effects compared with homologous BNT.

Conclusions
Within the limitations of this study, heterologous vaccination with ChAd/BNT appears to induce stronger humoral immunity and more frequent but manageable side effects than homologous vaccination with BNT/BNT or with ChAd/ChAd in COVID-19-naïve hemodialysis patients.

Graphical abstract
High-Efficiency Electromagnetic Interference Shielding of rGO@FeNi/Epoxy Composites with Regular Honeycomb Structures
Authors: Song Ping , Ma Zhonglei , Qiu Hua , Ru Yifan , Gu Junwei 
Published: January 2022

Abstract
With the rapid development of fifth-generation mobile communication technology and wearable electronic devices, electromagnetic interference and radiation pollution caused by electromagnetic waves have attracted worldwide attention. Therefore, the design and development of highly efficient EMI shielding materials are of great importance. In this work, the three-dimensional graphene oxide (GO) with regular honeycomb structure (GH) is firstly constructed by sacrificial template and freeze-drying methods. Then, the amino functionalized FeNi alloy particles (f-FeNi) are loaded on the GH skeleton followed by in-situ reduction to prepare rGH@FeNi aerogel. Finally, the rGH@FeNi/epoxy EMI shielding composites with regular honeycomb structure is obtained by vacuum-assisted impregnation of epoxy resin. Benefitting from the construction of regular honeycomb structure and electromagnetic synergistic effect, the rGH@FeNi/epoxy composites with a low rGH@FeNi mass fraction of 2.1 wt% (rGH and f-FeNi are 1.2 and 0.9 wt%, respectively) exhibit a high EMI shielding effectiveness (EMI SE) of 46 dB, which is 5.8 times of that (8 dB) for rGO/FeNi/epoxy composites with the same rGO/FeNi mass fraction. At the same time, the rGH@FeNi/epoxy composites also possess excellent thermal stability (heat-resistance index and temperature at the maximum decomposition rate are 179.1 and 389.0 °C respectively) and mechanical properties (storage modulus is 8296.2 MPa).
Measuring Time Preferences Using Stated Credit Repayment Choices
Authors: Li Hanjin , Campbell Danny , Erdem Seda 
Published: January 2022

AbstractThis paper explores consumers’ repayment decisions and their time preferences. We do this through a hypothetical study using a stated-preference approach. In our experiment, participants are asked to make repayment decisions over time, under different loan sizes. We report five choice trajectories: minimum delay, monotonically decreasing, trajectory with one contradicting choice, trajectory with more than one contradicting choice, and maximum delay. These choice trajectories are taken into account in our modelling approach. Our analysis uses choice models that jointly estimate the discount rate and the probability of choice trajectories. Observed heterogeneity in repayment behaviour is further analysed using sociodemographic factors, and tested for the two loan sizes. We report heterogeneity in consumer repayment decisions, and what happens in the decision-making process for participants in different sociodemographic groups, for different loan sizes. These findings suggest that decision-makers can tailor their strategy for mitigating consumer debts by targeting different groups in the population demonstrating different choice behaviour and decision-making.
PID controls: the forgotten bioprocess parameters
Authors: Harcum Sarah W. , Elliott Kathryn S. , Skelton Bradley A. , Klaubert Stephanie R. , Dahodwala Hussain , Lee Kelvin H. 
Published: January 2022

AbstractThe ambr250 high-throughput bioreactor platform was adopted to provide a highly-controlled environment for a project investigating genome instability in Chinese hamster ovary (CHO) cells, where genome instability leads to lower protein productivity. Development of the baseline (control) and stressed process conditions highlighted the need to control critical process parameters, including the proportional, integral, and derivative (PID) control loops. Process parameters that are often considered scale-independent, include dissolved oxygen (DO) and pH; however, these parameters were observed to be sensitive to PID settings. For many bioreactors, control loops are cascaded such that the manipulated variables are adjusted concurrently. Conversely, for the ambr250 bioreactor system, the control levels are segmented and implemented sequentially. Consequently, each control level must be tuned independently, as the PID settings are independent by control level. For the CHO cell studies, it was observed that initial PID settings did not resulted in a robust process, which was observed as elevated lactate levels; which was caused by the pH being above the setpoint most of the experiment. After several PID tuning iterations, new PID settings were found that could respond appropriately to routine feed and antifoam additions. Furthermore, these new PID settings resulted in more robust cell growth and increased protein productivity. This work highlights the need to describe PID gains and manipulated variable ranges, as profoundly different outcomes can result from the same feeding protocol. Additionally, improved process models are needed to allow process simulations and tuning. Thus, these tuning experiments support the idea that PID settings should be fully described in bioreactor publications to allow for better reproducibility of results.
Proto Kranz-like leaf traits and cellular ionic regulation are associated with salinity tolerance in a halophytic wild rice
Authors: Yong Miing-Tiem , Solis Celymar Angela , Amatoury Samuel , Sellamuthu Gothandapani , Rajakani Raja , Mak Michelle , Venkataraman Gayatri , Shabala Lana , Zhou Meixue , Ghannoum Oula , Holford Paul , Huda Samsul , Shabala Sergey , Chen Zhong-Hua 
Published: January 2022

AbstractSpecies of wild rice (Oryza spp.) possess a wide range of stress tolerance traits that can be potentially utilized in breeding climate-resilient cultivated rice cultivars (Oryza sativa) thereby aiding global food security. In this study, we conducted a greenhouse trial to evaluate the salinity tolerance of six wild rice species, one cultivated rice cultivar (IR64) and one landrace (Pokkali) using a range of electrophysiological, imaging, and whole-plant physiological techniques. Three wild species (O. latifolia, O. officinalis and O. coarctata) were found to possess superior salinity stress tolerance. The underlying mechanisms, however, were strikingly different. Na+ accumulation in leaves of O. latifolia, O. officinalis and O. coarctata were significantly higher than the tolerant landrace, Pokkali. Na+ accumulation in mesophyll cells was only observed in O. coarctata, suggesting that O. officinalis and O. latifolia avoid Na+ accumulation in mesophyll by allocating Na+ to other parts of the leaf. The finding also suggests that O. coarctata might be able to employ Na+ as osmolyte without affecting its growth. Further study of Na+ allocation in leaves will be helpful to understand the mechanisms of Na+ accumulation in these species. In addition, O. coarctata showed Proto Kranz-like leaf anatomy (enlarged bundle sheath cells and lower numbers of mesophyll cells), and higher expression of C4-related genes (e.g., NADPME, PPDK) and was a clear outlier with respect to salinity tolerance among the studied wild and cultivated Oryza species. The unique phylogenetic relationship of O. coarctata with C4 grasses suggests the potential of this species for breeding rice with high photosynthetic rate under salinity stress in the future.