bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noncoding RNAs: A New Layer of Functional RNAs
Authors: Gurer Dilek Cansu , Akgül Bünyamin 
Published: June 2022

Abstract:
The conventional central dogma of molecular biology dictates that the genetic information
contained within deoxyribonucleic acid (DNA) is passed onto messenger ribonucleic acids
(mRNAs), which are then used as templates to synthesize proteins. Although these types of proteincoding
genes have been historically prioritized in typical phenotype-genotype studies with a parallel
disregard to the rest of the genome, the completion of genome projects has unveiled a surprising
layer of genetic information that can play critical roles in cellular processes without coding for proteins.
These types of genes are called noncoding genes as they do not code for proteins. Noncoding
genes come in different sizes and shapes, and they are just as versatile in carrying out cellular biochemical
processes as proteins. In this review, we cover a comprehensive review of housekeeping
and regulatory noncoding genes and their mode of action.
Molecular Docking and Simulation Studies of Flavanone and its Derived
Compounds on PI3K-AKT Pathway Targeting against Cancer
Authors: Swamy K. Venkateswara , Nagare Sagar , Lokhande Kiran Bharat 
Published: June 2022

Background:
Flavanone compounds and its related derivatives are reported to participating in controlling cell cycle, Angiogenesis, and metastasis. Phosphoinositide 3-kinases is major drug target.

Methods:
Crystalize structure of Phosphoinositide 3-kinases-Akt complex obtained from Protein Data Bank (PDBID: 3CQW) was selected as receptor protein and binding site has been identified with PDBSum Database. Flavanone and its derivatives were retrieved using freely available existing drug database like Drug Bank, Zinc and PubChem. Modifications of new derivatives was performed by altering the flavanone at Beta ring position this modification would help in maintaining stable structural conformation and retaining better anticancer activity. Retrieved Flavanone derivatives from the drug database were docked against 3CQW Protein with advance docking tool FlexX. MD simulations of best molecule were performed with Desmond package by calculating nonbonding interactions such as electrostatic interaction and hydrogen bond stable and favorable conformations were calculated.

Results:
These interaction studies would help in identifying new potential drug candidate with the help of computer aided drug designing techniques.

Conclusion:
Natural chemicals have received a lot of attention because of their vast range of applications in human health and disease prevention without creating any negative side effects. Molecular docking is an essential approach for drug development since it allows for effective screening of potential therapeutics in a short amount of time. We hypothesized in this paper that natural Flavanone and its derivatives may be effective as Akt-1 inhibitors.
Gd-EOB-DTPA Enhanced MRI Features of Liver Hemangiomatosis
Coexistent with GCH
Authors: Ye Aihua , Hu Chunhong , Liu Dong , Qiao Zhenguo , Xu Lihua , Fu Fangfang 
Published: June 2022

Objectives:
This study aimed to clarify features of giant cavernous hemangioma (GCH) and
liver hemangiomatosis, existing simultaneously on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic
acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI).

Methods:
A total of 17 patients with reported hepatic hemangiomatosis between 2015 and 2017 were
identified retrospectively. All our patients underwent pre-contrast MRI, triphasic (atrial, portal, venous)
Gd-EOB-DTPA dynamic enhancement and hepatobiliary phase (20 minutes delayed). The location,
size, morphology and signal characteristics on T1-weighted (T1WI) and T2-weighted images
(T2WI), and Gd-EOB-DTPA-enhanced MRI of liver hemangiomatosis were evaluated.

Results:
Hemangiomatosis involved the liver adjacent to the edge of the GCH with no normal liver
tissue found in 13 cases; in the other 4 patients, a small area of normal liver tissue separated GCH from
hemangiomatosis was seen. On non-contrast MRI images, hemangionmatosis presented as numerous
microcystic lesions, with low signal intensity on T1WI and high signal intensity on T2WI, compared
with unaffected liver. After administration of Gd-EOB-DTPA, heterogeneous enhancement was presented
in the arterial phase, during portal and venous phase imaging, becoming more homogeneous. 11
cases showed hypointensity in the hepatobiliary phase (6 cases with intratumor necrosis), and 6 cases
showed hyper-intensity in the hepatobiliary phase with a remaining unfilled portion.

Conclusion:
Hemangiomatosis is extremely rare in the liver adjacent to a GCH. MRI is of great diagnostic
and clinical value for this kind of tumor according to the configuration, size, signal, and style of
enhancement, but the final diagnosis depends on pathology. Gd-EOB-DTPA-enhanced MRI may help
in diagnosing hemangiomatosis coexistent with GCH.
A Comprehensive Review on Therapeutic Potential of Chrysin in Brain
Related Disorders
Authors: Goyal Ahsas , Singh Geetanjali , Verma Aanchal 
Published: June 2022

Abstract:
Brain disorders are currently one of the world's most serious and difficult health issues.
These brain disorders are accountable for a massive number of morbidities and mortalities around the
world. The current treatments of these disorders are frequently accompanied by severe side effects and
cause a detrimental effect on health. Recently, plant flavonoids have sparked a surge in public and scientific
attention because of their alleged health-promoting impact and almost no adverse repercussions.
Also, scientific research has shown that phytochemicals possess numerous neuroprotective
properties under in vivo and in vitro conditions. Chrysin is a therapeutic phytochemical that falls under
the class of flavonoids based on its structure. The biological activities and pharmacological effects of
chrysin include anticancer, antioxidant, and anti-inflammatory activities as well as amyloidogenic and
neurotrophic effects. These therapeutic abilities of chrysin are attributed to its structural diverseness
arising in ring-A and lack of oxygenation in B and C rings. Several studies have highlighted the rising
significance of chrysin in a variety of brain illnesses, like Alzheimer's disease, Parkinson's disease, depression,
anxiety, brain tumours, epilepsy, multiple sclerosis, traumatic brain injury, spinal cord injury,
and ischemic stroke. This study depicts the relationship of chrysin with different brain-related disorders
and discusses the mechanisms responsible for the potential role of chrysin as a pharmacological
agent for the treatment and management of different brain disorders based on the results of several
preclinical studies and taking into account the therapeutic effects of the compound.
Chemical Composition, Antioxidant, Antimicrobial, and Immunomodulatory
Activity of Mandragora autumnalis Grown in Jordan
Authors: Talib Wamidh H. , Mahmod Asma Ismail 
Published: June 2022

Background:
The activity of phytochemicals has a huge impact on pharmaceutical research
and developing new drugs. Hence, numerous studies have been conducted to investigate the efficacy
of different natural products and their potential to be used in different types of therapy.

Objective:
This study was carried out to investigate the biological activity of M. autumnalis crude
extract and fractions, and the assessment included antimicrobial activity, radical scavenging potential,
and their effect on the immune system. The work also emphasizes determining the chemical constituents
and the main bioactive compounds in M. autumnalis leaves.

Methods:
Ethanol crude extract was prepared by maceration method, followed by solvents fractionation
using n-hexane, aqueous/methanol, and water. Phytochemical analysis of ethanol extract using
LC-MS and total phenolic and flavonoid content were conducted. The immunomodulatory activity
was also evaluated by measuring the effect of M. autumnalis on splenocyte proliferation in the presence
and absence of mitogens. Nitro blue tetrazolium assay and neutral red method have been used to
determine the effect of M. autumnalis on the phagocytic activity of macrophages and the function of
pinocytosis, respectively. Antibacterial assay was applied using the microtiter plate dilution method,
and DPPH assay was used to determine the antioxidant activity.

Results:
The phytochemical analysis has shown the presence of flavonoids, polyphenolic compounds,
and other organic acids like quinic and chlorogenic acids. M. autumnalis aqueous fraction exhibited
high antioxidant activity with an IC₅₀ value of 23.67±0.3 μg/ml. Ethanol extract and n-hexane fraction
inhibited the bacterial growth of P. auriginosa with an MIC value of 25 mg/ml, while n-hexane fraction
was more active against C. albicans with an MIC value of 12.5 mg/ml. On the other hand, the
immune assay revealed a slight modulation of the lymphocyte and macrophage activity compared to
the control results.

Conclusion:
The results suggested that M. autumnalis leaves are rich in polyphenolic compounds and
its crude extract and fractions exhibited antimicrobial and antioxidant potential. However, further research
is needed to understand the effect of M. autumnalis on the immune parameters.
A Glance at Dysprosium Oxide Free Powders
Authors: Cardoso Santos Silas , Rodrigues Orlando , Lucente Campos Letícia 
Published: June 2022

Background:
Dysprosium oxide (Dy2O3) gathers a set of profitable properties with a
wide range of applications, including energy and astronomy. Particular characteristics directly influence
the formation and features of materials by colloidal processing. The main purpose of this
paper is to carry out a powder characterization of Dy2O3 particles. The findings reported are
worthwhile parameters to advance in the formulation of new smart materials for radiation dosimetry.

Methods:
Dy2O3 powders were characterized by XRD, PCS, SEM, pynometric density (ρ), FTIR,
ICP, EPR, and zeta potential (ζ).

Results:
The powdered samples exhibited as main features a cubic C-type structure following the
RE-polymorphic diagram, a mean particle size distribution with d50 of 389nm, and pynometric
density of 7.94g.cm-3. The EPR spectra revealed three distinct peaks, p1, p2, and p3, with the following
g values: 2.3121, 2.1565, and 2.1146. In addition, the nanoparticles presented high stability
at pH 5.5 and a ζ-value of |49.7|mV.

Conclusion:
The powder characterization of Dy2O3 powders was reported. The results achieved
in this study may be considered worthwhile parameters to advance in the formulation of Dy2O3-
based materials for radiation dosimetry.
The affecting factors of choosing delivery place in Working Area of Sikumana Health Center
Authors: Nuhan Maria Vilastry , Sormin Roslin E , Bhoko Mardiana S 
Published: June 2022

<p><strong><em>Background:</em></strong><em> </em><em>One of the causes of maternal and infant mortality is childbirth that still occurs at home with inadequate health facilities. Delivery at adequate health care facilities can reduce Mother Mortality Rate and Infant Mortality Rate. </em></p><p><strong><em>Objectives:</em></strong><em> </em><em>This study aims to analyze the effect of antenatal care, family support and health support of workers regarding a place of delivery choice based on the MCH Revolution in working area of Sikumana Health Center, Kupang. </em></p><p><strong><em>Methods:</em></strong><em> </em><em>This study used a case control design. The sample size of the case group was 30 women who gave birth in non-adequate health facilities and the control group was 30 women who gave birth in adequate health facilities. The sample collected by random sampling technique</em><em> and used direct interview and questionnaire. </em><em>Data analysis was carried out using Chi Square statistical test. </em></p><p><strong><em>Results:</em></strong><em> </em><em>The results of the analysis indicated that from the studied variables, variables that influenced the choice of labor place were the mother's attitude (p = 0.000), and the history of previous place (p = 0.038), while the variable of mother's age did not affect (p = 0.778). </em></p><p><strong><em>Conclusion:</em></strong><em> T</em><em>he mother's attitude and previous delivery history had an effect on the choice of labor place, while the mother's age did not have any effect. These risk factors are expected to be a special concern for health workers in providing counseling for pregnant women in determining the place of labor. In addition, intense support from health workers is needed to motivate mothers and families to choose adequate health facilities as a place of labor.</em></p>
A Comparison of the Effects of Stochastic Resonance Therapy, Whole-Body Vibration, and Balance Training on Pain Perception and Sensorimotor Function in Patients With Chronic Nonspecific Neck Pain: Protocol for a Randomized Controlled Trial
Authors: Igbokwe Emmanuel Osinachi , Taube Wolfgang , Beinert Konstantin 
Published: June 2022

Background
Neck pain is a prevalent pathological condition, and together with low back pain, it presents as the leading cause of years lived with disability worldwide in 2015 and continues to contribute substantially to the global burden of disease.

Objective
This study will investigate and compare the effects of stochastic resonance therapy (SRT), whole-body vibration (WBV), and balance training (BLT) in the management of chronic nonspecific neck pain.

Methods
In total, 45 participants with chronic neck pain will be randomly allocated into SRT, WBV, and BLT groups. Pain intensity, pressure pain threshold, neck disability, and cervical joint position sense will be measured before, immediately after, and 15 minutes after the first intervention session and after 4 weeks of intervention. A follow-up postintervention measurement would be taken after 4 weeks. The SRT group will train on an SRT device (SRT Zeptor Medical plus noise, Zeptoring). The WBV group will train on a Galileo vibration device (Novotec Medical), while the BLT group will perform balance exercises. All participants shall train 3 times a week for a period of 4 weeks. Mixed ANOVA will be used to determine the main and effects of interactions within (before intervention, post intervention 1, post intervention 2, post intervention 3, and follow-up) and between (SRT, WBV, and BLT) factors on the study outcome variables.

Results
Recruitment of participants started in May 2021, and as of May 2022, a total of 20 patients have been enrolled in the study. All participants are expected to have completed the trial by the end of 2022, and data analysis will commence thereafter.

Conclusions
The outcome of this study will shed closer light on the effects of SRT, WBV, and BLT on pain and function in patients with chronic neck pain.

Trial Registration
German Clinical Trials Register DRKS00023881; https://tinyurl.com/ycxuhj37

International Registered Report Identifier (IRRID)
DERR1-10.2196/34430
Telemedicine Preparedness Among Older Adults With Chronic Illness: Survey of Primary Care Patients
Authors: Ufholz Kelsey , Sheon Amy , Bhargava Daksh , Rao Goutham 
Published: June 2022

Background
Older adults are a high priority for telemedicine given their elevated COVID-19 risk and need for frequent provider contact to manage chronic illnesses. It seems that many older adults now use smartphones but few studies have examined their overall readiness for telemedicine.

Objective
The aim of this study is to survey older primary care patients about their telemedicine preparedness, including internet usage, internet-capable devices, telemedicine experiences and concerns, and perceived barriers. Results were used to inform a telemedicine preparedness training program.

Methods
Community-dwelling older adult patients (aged 65-81 years; N=30) with a chronic health condition that could be managed remotely who were present at a family medicine clinic that primarily serves an urban African American population for a prescheduled in-person appointment were asked to complete a brief survey written for this study. Data were collected February-June 2021 at a large, urban, Midwestern hospital. To minimize patient burden, the survey was limited to 10 questions, focused on the most critical topics.

Results
Most participants (21/30, 70%) reported having a device that could be used for telemedicine and using the internet. However, about half had only a single connected device, and messaging and video calling were the most commonly used applications. Few used email and none used online shopping or banking. Only 7 patients had had telemedicine appointments. Telemedicine users were younger than nonusers and used more internet functions than nonusers. Only 2 people reported problems with their telemedicine visits (technology and privacy). Nearly all respondents recognized avoiding travel and COVID-19 exposure as telemedicine benefits. The most common concerns were loss of the doctor-patient connection and inability to be examined.

Conclusions
Most older adults reported having devices that could be used for telemedicine, but their internet use patterns did not confirm the adequacy of their devices or skills for telemedicine. Doctor-patient conversations could be helpful in addressing telemedicine concerns but device and skill gaps must be addressed as well.
Pengaruh Pemberian Kalsium Silikat terhadap Pertumbuhan dan Struktur Anatomi Akar Tanaman Padi (<i>Oryza sativa</i> L. ‘IR64’) pada Kondisi Cekaman Salinitas
Authors: Irsyad Aliya Nadira , Rachmawati Diah 
Published: June 2022

Salinitas merupakan salah satu cekaman abiotik yang umum terjadi di lahan persawahan. Salinitas dapat menyebabkan produktivitas padi menurun akibat terhambatnya pertumbuhan tanaman padi. Salah satu cara untuk mengurangi dampak negatif cekaman salinitas yaitu dengan aplikasi pupuk silikat. Pupuk silikat sebagai sumber silikon (Si) dapat meningkatkan pertumbuhan serta toleransi tanaman padi saat berada pada kondisi cekaman biotik maupun abiotic, salah satunya salinitas. Tujuan penelitian ini adalah untuk mempelajari pengaruh kalsium silikat terhadap pertumbuhan, dan struktur anatomi akar tanaman padi ‘IR64’ pada kondisi cekaman salinitas. Penelitian dilakukan menggunakan Rancangan Acak Lengkap dengan dua faktor yaitu kalsium silikat dan salinitas. Konsentrasi yang digunakan pada perlakuan kalsium silikat 0, 1, dan 2 mM serta untuk perlakuan salinitas 0, 37.5, dan 50 mM NaCl. Data yang diperoleh dianalisis dengan menggunakan analisis varian (ANOVA) dan jika terdapat pengaruh maka dilanjutkan dengan menggunakan uji DMRT dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa aplikasi kalsium silikat meningkatkan pertumbuhan tanaman padi ‘IR64’ pada kondisi cekaman salinitas. Pada kondisi cekaman salinitas, aplikasi kalsium silikat mampu meningkatkan diameter akar, tebal eksodermis, tebal korteks, dan diameter stele tanaman padi ‘IR64’.
Los diarios deportivos digitales en Colombia. Nuevas tendencias del periodismo
Authors: Zambrano Ayala William Ricardo 
Published: June 2022

El periodismo se está replanteando debido a la transformación de los medios y al impacto de las nuevas tecnologías en cada una de las fases del proceso periodístico. Estos cambios también han impactado al periodismo deportivo. Por tales razones, se traza el objetivo general de analizar cuatro diarios deportivos digitales colombianos de mayor consulta en el país: FutbolRed, Marca, AS y El Periódico Deportivo. Para ello se realiza una investigación cualitativa y cuantitativa descriptiva, analítica, correlacional y prospectiva mediante entrevistas, grupos focales, observación y encuestas.
Los hallazgos identifican que la actualización de información de estos diarios deportivos digitales la realizan en promedio cada tres horas, la interactividad con el usuario es esporádica, la producción de contenidos es por agregación con tinte de espectacularidad y poca profundidad, la agenda noticiosa es repetida, no distinguen lo significativo con lo irrelevante, priman la noticia y opinión, la gestión informativa es similar a la competencia, la suscripción es abierta y la distribución es automatizada en plataformas, redes sociales y correos electrónicos.
Se concluye que estos diarios han modificado la participación con las audiencias, las rutinas periodísticas en las redacciones, el consumo de nuevos contenidos, la circulación y el rating. Por consiguiente, estos medios digitales están implementando una ecología informativa novedosa que está impactando los estilos y prácticas del periodismo deportivo.
Determining Important Carrier Attributes: A Fresh Perspective Using the Theory of Reasoned Action
Authors: VOSS M. DOUGLAS , PAGE, THOMAS J. , KELLER SCOTT B. , OZMENT JOHN 
Published: June 2022

Abstract
The world has changed a great deal since the most recent installment in the carrier selection criteria literature. The terrorist attacks of September 11th, the recession that followed, and a current business environment characterized by constrained transportation capacity are all likely to have changed the emphasis shippers place on attributes used to select carriers. First, the authors posit three selection criteria have grown more important in the post-September 11th world. Second, the benefits of utilizing the Theory of Reasoned Action to determine the most important selection criteria, and to identify the parties in the shipping organization who value these criteria, are explained. Third, results of an exploratory study demonstrating the usefulness of the Theory of Reasoned Action to predict carrier choice are illustrated. Implications and contributions to academic research and industry practice are then discussed.
Predictive Methods for Using Capacity Data to Estimate Market Shares and the Extent of Risk Pooling by Airline Alliance Partners under Parallel Codesharing
Authors: CHEN CHIALIN , REN YU 
Published: June 2022

Abstract
Forming strategic alliances has become a common practice for major airlines in today's global market. The arrangement of parallel codesharing provides alliance partners serving the same route with the unique opportunity to conduct risk pooling with shared capacity and information. In this article, we develop predictive methods to analyze the effects of capacity sharing and risk pooling on the market and operational performances of airline alliance partners under parallel codesharing. We establish the interrelationship between market share and capacity through the total demands and probabilities under four different cases of demand/supply allocations between two alliance partners. We also propose methods for identifying the values of key parameters to estimate the extent of risk pooling on selected international routes. Our analyses show that risk pooling with shared capacity is a common phenomenon on the selected routes under parallel codesharing. In addition, some of the routes have rather uneven distributions of the opportunity for risk pooling between alliance partners. Several applications of the proposed methods in both the private and public sectors, such as evaluating gain-sharing by alliance partners, revising bilateral agreements, as well as fine-tuning capacity-, revenue-, and cost-sharing arrangements, are also discussed.