bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respon Tanaman Padi Sawah Terhadap Pemberian Pupuk Organik Cair Jago Tani
Authors: Tukidi  , Rusnani  , Junaidi Ibrahim  
Published: July 2022

The purpose of this research is to know the response of wetland rice production to the application of liquid organic fertilizer of farmer. This research has been done in Suka Jaya Rice Seed Hall of Jembatan Mas village Batang Hari District. The study was conducted from March to August 2014. The experiment was designed with Randomized Block Design (RAK). Organic fertilizer liquid liquid farmer in the test consisted of 6 treatments.dan 4 times replication P0 = Without liquid organic fertilizer farmer, P1 = Organic fertilizer liquid juice farmer as much as 1 cc / liter of water, P2 = organic fertilizer liquid farmer as much as 2 cc / liter of water, P3 = Liquid organic fertilizer for farmer as much as 3 cc / liter of water, P4 = Liquid organic fertilizer farmer as much as 4 cc / liter of water and P5 = Organic liquid farmer farmer as much as 5 cc / liter of water. The results showed that the application of liquid organic fertilizer does not affect the number of productive tillers, weights 1000 grains, but the effect on yield per hectare. The concentration of 3 cc / liter of water gives the best yield reaching 6.61 ton / ha.
STUDI LITERATUR REVIEW TERHADAP PENELITIAN EARNINGS RESPONSE CEOFFICIENT
Authors: Sungloria Calvin Restu Junior , Chinthya C. , Rivario Devin , Luis Gunawan  
Published: July 2022

Studi literatur ini dilakukan untuk mengevaluasi penelitian terhadulu yang menggunakan variabel-variabel yang memepengaruhi earnings response coefficient.koefisien respon laba adalah suatu alat ukur yang menunjukkan respon pasar pada informasi laba yang diberikan oleh perusahaan. Karena terdapat faktor-faktor yang mempengaruhi koefisien respon laba maka yang digunakan dalam penelitian ini adalah growth opportunity, leverage, persistensi laba, dan ukuran perusahaan. penelitian yang dilakukan menggunakan metode studi literatur yang meneliti dan menganalisa artikel yang berhubungan dengan koefisien respon laba. Untuk meningkatkan kepercayaan investor dan meningkatkan reaksi pasar terhadap perusahaan maka perusahaan harus memiliki leverage yang kecil dan harus meningkatkan growth opportunity, ukuran perusahaan dan persistensi laba. Penelitian menunjukan hasil bahwa growth opportunity dan leverage memiliki pengaruh negatif pada koefisien respon laba. Tetapi persistensi laba dan ukuran perusahaan memiliki hasil memberikan dampak atau pengaruh pada koefisien respon laba.
Response of Native Chickens (3-10 Weeks) Fed on Diets Substituated With Graded Levels of Sweet Potato Fermentation
Authors: Frengki Damu Lodu  , Suwitari Ni Ketut Etty , Luh Suariani  
Published: July 2022

The purpose of this study was to determine the effect of giving fermented sweet potato waste in the ration on the appearance of native chickens aged 3 - 10 weeks and to find out what percentage of the level of use of fermented sweet potato waste in the ration. This study used a completely randomized design (CRD) with 5 treatments and 3 replications. The treatments consisted of: R0 = ration without additional fermented sweet potato waste as control, R1 = ration containing 3% unfermented sweet potato was, R2 = ration containing 3% fermented sweet potato waste, R3 = ration containing 6% fermented sweet potato waste, R4 = The ration contains 9% fermented sweet potato waste. Each replication (experimental unit) used 5 native chickens so that the number of chickens used was 75. The use of sweet potato waste fermentation in the ration had no significant effect (P>0.05) on initial body weight, final body weight , weight gain,and feed convertion ratio. Feeding of fermented sweet potato waste to a level of 3% (R2) gave optimal results.
Exercise and Sports Activities in Patients with Heart Failure
Authors: Laksono Sidhi , Kusharsasmita Hillary 
Published: July 2022

Exercise training is an essential additional non-pharmacological method to treat heart failure patients that has been shown to have significant impacts on mortality, morbidity, exercise capacity and quality of life. Various type of training are developed to resolve the needs of heart failure patients, including those who want to participate in sport activities. It is critical and challenging to prescribe personalized exercise training program perfectly, therefore, this review provides brief overview of the advantages and recommendations to prescribe individualized type of exercise training including aerobic, resistance, respiratory, aquatic and competitive sport activities for patients with heart failure. A comprehensive electronic search was conducted using PubMed, Google Scholar, and ScienceDirect. The search was limited to English-language publications from 2004 to 2021. Hand searching of relevant journals and reference lists was also performed. Exercise training should be component of a comprehensive heart failure care approach. Each patient with heart failure may have a different endurance to tolerate the same relative training. Individualized exercise training combined with a preliminary examination improves disability while also decreasing morbidity and mortality
Keywords: heart failure, nonpharmacological management, sport exercise
The Effect of Type II DM on the Incidence of Sensorineural Deafness at Bali Royal General Hospital
Authors: Santosa Agus , I Wayan Sulistiawan  
Published: July 2022

Type II diabetes mellitus (DMT II) is a major health threat, and DM is known to be associated with sensorineural deafness. Age, duration of DM, hypertension and hypertriglycerides are believed to influence this process. This study aims to determine the relationship between type II DM and the incidence of sensorineural hearing loss at Bali Royal General Hospital. The study used a case control design which was carried out on patients admitted between July-September 2021 at Bali Royal General Hospital. The sampling technique employed in the DMT II group with sensorineural deafness was total random sampling, while for comparison, simple random sampling was used. The analyses were carried out by descriptive analysis, chi square test for bivariate data, and logistic regression test for multivariate analysis. The p value is said to be meaningful if <0.05. The whole process of data analysis in this study used SPSS.sav 25. The number of samples was 8 patients with an average age of 49.62 ± 8.45. The mean of RBS (Random Blood Sugar) sugar was 152.25±60.92 mg/dL, and FBS (Fasting Blood Sugar) was 87.87±14.09 mg/dL. Patients with low FBS values ​​and diabetes duration of <5 years had more normal hearing conditions in the right ear (60%), while patients with high FBS and diabetes duration of ≥5 years had more SNHL (66.7%). However, the two conditions did not show a statistically significant relationship (p>0.05). The results of multivariate analysis found that there was no significant relationship between FBS levels and age with hearing conditions in the left ear (p> 0.05). In this study, there was no significant relationship between FBS, duration of DM, pattern of drug consumption, age, and hypertension status of DM patients with the incidence of SNHL in the right and left ears.
Keywords: Type II diabetes mellitus, sensorineural deafness, hearing loss
Smooth Muscle Insulin Receptor Deletion Causes Voiding Dysfunction: A Mechanism for Diabetic Bladder Dysfunction
Authors: Chen Huan , Wu Ali , Zeidel Mark L. , Yu Weiqun 
Published: July 2022

<p>Diabetic bladder dysfunction (DBD) is the most common complication in diabetes mellitus (DM). Myogenic abnormalities are common in DBD, however, the underlying mechanisms leading to these remains unclear. To understand the importance of smooth muscle insulin receptor (IR)-mediated signaling in the pathogenesis of DBD, we conditionally deleted it to achieve either heterozygous (<em>SMIR+/-</em>) or homozygous (<em>SMIR-/-</em>) deletion in smooth muscle cells. Despite impaired glucose and insulin tolerance seen with <em>SMIR-/-</em> mice, both <em>SMIR+/- </em>and <em>SMIR-/-</em> mice exhibited normal blood glucose and plasma insulin levels. Interestingly, these mice had abnormal voiding phenotypes, that included urinary frequency and small voids, and bladder smooth muscle (BSM) had significantly diminished contraction force. Morphology revealed a dilated bladder with thinner BSM layer, and BSM bundles were disorganized with penetrating interstitial tissue. Deletion of IR elevated FoxO and decreased mTOR protein expression, which further decreased the expression of Chrm3, P2x1, Sm22, and Cav1.2, crucial functional proteins for BSM contraction. Furthermore, we determined the expression of adiponectin in BSM, and deletion of IR in BSM inhibited adiponectin-mediated signaling. In summary, disruption of IR-mediated signaling in BSM caused abnormalities in proliferation and differentiation, leading to diminished BSM contractility and a voiding dysfunction phenotype that recapitulates human DBD. </p>
EFL Lecturers’ and Students' Perception towards Online Learning in Riau context: Using Technology Acceptance Model (TAM) as the Organizing Framework
Authors: Budiyanti Kurnia , Amelia Riza , Natasha Harum 
Published: July 2022

Online learning in the pandemic has been conducted with less preparation by both the teachers and the students. Whether or not it has been effective, little is known. The research aims to conduct research on EFL lecturers’and students’ perception toward online learning from the perspective of technology acceptance model by Davis et al. (1989). The design of the reserch is descriptive quantitative. There were 14 EFL lecturers and 121 EFL students recruited in the study. Data collection method was a questionnaire with a 5-Likert scale. Data analysis was descriptive statistics. The findings reveal that the lecturers’perceived usefulness and the perceived ease-of-use fall on high category (respectively, 72,95% and 71,1%) and the students’ lecturers’perceived usefulness and the perceived ease-of-use fall on high category (respectively, 79.10% and 72.50%). Out of all items, the lecturers mostly appreciated the flexibility of online learning in term of time and place (82.86%); and the students mostly appreciated the online learning’s opportunity to study English ((77,19%). Some suggestions are given to future researchers, namely (1) the next researcher can recruit more participants, (2) the next researcher can use different instruments to collect the data, like observation, interview and tests. Keywords: online learning, perceived usefulness, perceived ease-of-use, face-to-face.
A model of transient laryngeal hemiplegia in dogs through conduction blockade of the recurrent laryngeal nerve
Authors: Martin-Flores Manuel , Sakai Daniel M. , Campoy Luis , Cheetham Jonathan 
Published: July 2022

Abstract

OBJECTIVE
To create a model of transient unilateral laryngeal paralysis (LP) that will allow the study of cricoarytenoideus dorsalis dysfunction and a method for quantification of varying degrees of LP in dogs.

ANIMALS
5 castrated male research Beagles.

PROCEDURES
Between January and February 2018, dogs were anesthetized and instrumented with a laryngeal mask airway and a flexible endoscope to record the rima glottidis. The left or right recurrent laryngeal nerve (RLn) was localized using ultrasonography and electrical stimulation, then conduction blockade was induced with perineural lidocaine. The normalized glottal gap area (NGGA) was measured before and every 15 minutes after the block. Inspired 10% carbon dioxide (CO2) was administered for 1 minute at each sampling time. The inspiratory increase in NGGA (total and each side) was measured at peak inspiration. The change in hemi-NGGA for the control side versus the anesthetized side was evaluated with a mixed-effect model.

RESULTS
During CO2 stimulation, the increase in inspiratory hemi-NGGA was consistently less (P < .001) for the treated side (–8% to 13%) versus the control side (49% to 82%). A compensatory increase (larger than at baseline) in the control hemi-NGGA was observed. The total NGGA remained unaffected.

CLINICAL RELEVANCE
Unilateral local anesthesia of the RLn produced transient unilateral LP with a compensatory increase in the hemi-NGGA for the contralateral side. This model could facilitate the evaluation of respiratory dynamics, establishment of a grading system, and collection of other important information that is otherwise difficult to obtain in dogs with LP.
Veterinarians should understand what it means to use conditionally approved drugs, with a focus on conditional approval of companion animal oncology drugs
Authors: Loss Christopher M. 
Published: July 2022

Abstract
The purpose of this article is to provide veterinarians with an understanding of what it means to use a conditionally approved drug. This article summarizes information that has been used to satisfy the reasonable expectation of effectiveness (RXE) standard for conditionally approved companion animal oncology drugs and compares that standard to the substantial evidence of effectiveness (SEE) standard. For conditional approval, the drug company must establish a RXE but need not demonstrate SEE. For a full approval (ie, New Animal Drug Application), the drug company must demonstrate SEE. Information to support a RXE for conditional approval of companion animal oncology drugs has included open-label pilot studies, retrospective analysis of medical records, use of a related formulation, and clinical field studies not meeting their primary effectiveness variable. Oncology drugs are highlighted in this article as they have made up many of the conditionally approved drugs to date. Veterinarians should understand that a conditionally approved drug does not have the same assurance of effectiveness as a drug receiving full approval. However, whether conditionally or fully approved, the drug has been demonstrated to be safe for the intended use. This report did not undergo scientific peer review.
A global one health perspective on leptospirosis in humans and animals
Authors: Sykes Jane E. , Haake David A. , Gamage Chandika D. , Mills W. Zach , Nally Jarlath E. 
Published: July 2022

Abstract
Leptospirosis is a quintessential one health disease of humans and animals caused by pathogenic spirochetes of the genus Leptospira. Intra- and interspecies transmission is dependent on 1) reservoir host animals in which organisms replicate and are shed in urine over long periods of time, 2) the persistence of spirochetes in the environment, and 3) subsequent human-animal-environmental interactions. The combination of increased flooding events due to climate change, changes in human-animal-environmental interactions as a result of the pandemic that favor a rise in the incidence of leptospirosis, and under-recognition of leptospirosis because of nonspecific clinical signs and severe signs that resemble COVID-19 represents a “perfect storm” for resurgence of leptospirosis in people and domestic animals. Although often considered a disease that occurs in warm, humid climates with high annual rainfall, pathogenic Leptospira spp have recently been associated with disease in animals and humans that reside in semiarid regions like the southwestern US and have impacted humans that have a wide spectrum of socioeconomic backgrounds. Therefore, it is critical that physicians, veterinarians, and public health experts maintain a high index of suspicion for the disease regardless of geographic and socioeconomic circumstances and work together to understand outbreaks and implement appropriate control measures. Over the last decade, major strides have been made in our understanding of the disease because of improvements in diagnostic tests, molecular epidemiologic tools, educational efforts on preventive measures, and vaccines. These novel approaches are highlighted in the companion Currents in One Health by Sykes et al, AJVR, September 2022.
Aberrant antigenic expression in acute leukemia: Study from a tertiary care center in Southern India
Authors: Hajra Subhajit , Panduragan Sathya , Manivannan Prabhu , Kar Rakhee , Basu Debdatta 
Published: July 2022

Objectives:Aberrant antigenic expression in acute leukaemia is an expression of antigens which is not normally associated with acute leukaemia of that specific lineage and does not fulfil the criteria for diagnosis of Mixed phenotype acute leukaemia (MPAL). This aberrant immunophenotype can be used for the assessment of measurable residual disease (MRD) and sometimes may predict certain genetic events.Material and Methods:This was a cross-sectional study conducted in a tertiary care centre in Southern India over two years to assess the type and frequency of aberrant antigen expression in acute leukaemia by multiparameter flow cytometry. All routine cases of acute leukaemia confirmed by flow cytometric immunophenotyping were enrolled.Results:Among 244 acute leukemia cases, 84 (34%) B-ALL, 28 (11%) T-ALL, 124 (51%) AML and 8 (3%) MPAL were found. Aberrant antigenic expression was seen in 17 (20%) B-ALL, 5 (18%) T-ALL, 33 (27%) AML and 1(12.5%) MPAL. Most common aberrancy in AML was CD7(70.3%) followed by CD19 (13.5%) and CD79a (10.8%), in B-ALL was CD33(52.6%) followed by CD13 (10.5%) and CRLF2 (10.5%) and in T-ALL were CD33 and CD 79a (40% each).Conclusion:B-ALL showed a greater heterogeneity in aberrant antigens compared to AML and T-ALL. The future implication of this study is that aberrant markers can help in monitoring measurable residual disease Some aberrant phenotypes may indicate the presence of a genetic event or may be of prognostic significance. Some aberrant antigens may also be used as therapeutic targets.
The place and role of leisure in the Moscow students’ everyday life in the context of the information society development
Authors: Nadekhina Yu. P. , Kolchin A. A. , Kryukova E. V. 
Published: July 2022

The proposed article discusses issues related to the daily life of Moscow students and their leisure, the relevance of which in the context of the development of the information society is associated with increased attention of the state to the educational component of modern educational systems. Moreover, in the conditions of modern realities of the development of the information society, and, consequently, information culture, the format of leisure becomes a significant factor in the socialisation of the individual. As a goal, the authors of the article identified the analysis of various forms of leisure activities of Moscow students through their questionnaires, which was designed to outline vectors for further research of the place and role of study, family relations and forms of spending free time in a student’s life. Special attention is paid to modern forms of leisure for students, such as: spending time on the Internet, visiting experimental theaters and cinemas, watching talk shows and entertainment programs, visiting immersive shows, participating in modern youth organisations, etc. Summarising the results of the study, it was concluded that at the moment no more than 20 % of the surveyed Moscow students choose “modern” forms of leisure activities. The conducted research revealed the students’ clear preferences in spending their free time, as well as their value orientations.
Partisipasi, Dependensi Dan Interelasi Masyarakat Dalam Pembangunan Berbasis Komunitas di Papua
Authors: Yuniarto Paulus Rudolf 
Published: July 2022

Pembangunan berbasis komunitas di pedesaan Papua sedikit banyak telah membuka pengetahuan pembangunan dan ruang keterlibatan masyarakat dalam proses perencanaan dan pelaksanaan kegiatannya. Namun Tridaya pembangunan (bantuan keuangan, pembangunan infrastruktur dan pemberdayaan sosial-ekonomi) terkendala persoalan internal dan eksternal. Di sisi internal, program pembangunan belum mampu mengaktifkan partisipasi seluruh kelompok masyarakat dalam kegiatan pembangunan dan mendorong terintegrasinya kegiatan sosial-ekonomi. Sebabnya adalah program kegiatan pembangunan masih terpusat pada sektor infrastruktur, kemudian informasi berada pada kelompok elit kampung dan pelaksanaan bersifat proyek. Di sisi eksternal, program bantuan yang diberikan bersifat karitatif dan tidak banyak menambah pasar maupun hasil produksi warga, malah membuat ketergantungan atas bantuan yang diberikan. Pembangunan pedesaan di Papua juga menimbulkan sentimen negatif di masyarakat—antara kelompok asli dengan pendatang maupun antara kelompok elit dengan masyarakat bawah—yang memicu persinggungan di dalam masyarakat maupun dengan negara.
Kata Kunci: Pembangunan Komunitas, Partisipasi, Dependensi, Interelasi.
PENGEMBANGAN BUKU PANDUAN MEMBATIK TERHADAP KEMAMPUAN FISIK MOTORIK HALUS ANAK USIA 5-6 TAHUN
Authors: Nimah Firkatun 
Published: July 2022

This study aimed to describe the development of products in the form of a batik handbook on physical motor skills that are suitable to use for children aged 5-6 years. The problem underlying the research is that fine motor learning activities are usually given with the assignment method using LKA and conducted in the classroom. These activities show less effective results to improve children's fine motor skills, therefore the researcher aimed to provide varied and fun activities for children by making batik activities. The method used is ADDIE (Analysis-Design-Development-Implementation-Evaluation) model development research. In this study used 3 stages of ADDIE research namely analysis stage, design stage, and development stage. The data collection method used a questionnaire with a validation sheet on material expert lecturers and media experts. The feasibility of the batik handbook media was reviewed from the aspect of graphic feasibility, the aspect of content feasibility, the aspect of presentation feasibility and the aspect of language feasibility. Based on the evaluation of the validity test in the overall development, the results obtained by media experts gained the score of 82.5% percentage included in the category of excellent qualifications. While the media experts got the percentage value is 89.5%. The percentage included in the category of excellent qualifications which means and is suitable for use in batik learning activities. Based on theses result it can be concluded that the hanbook of batik on the fine motoric physical abilities of children aged 5-6 years. The developmentof a batik guidebook for kindergarten teachers that can stimulate the fine motoric physical abilities of children aged 5-6 years.