bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene therapy using genome‐edited iPS cells for targeting malignant glioma
Authors: Tamura Ryota , Miyoshi Hiroyuki , Imaizumi Kent , Yo Masahiro , Kase Yoshitaka , Sato Tsukika , Sato Mizuto , Morimoto Yukina , Sampetrean Oltea , Kohyama Jun , Shinozaki Munehisa , Miyawaki Atsushi , Yoshida Kazunari , Saya Hideyuki , Okano Hideyuki , Toda Masahiro 
Published: September 2022

AbstractGlioblastoma is characterized by diffuse infiltration into the normal brain. Invasive glioma stem cells (GSCs) are an underlying cause of treatment failure. Despite the use of multimodal therapies, the prognosis remains dismal. New therapeutic approach targeting invasive GSCs is required. Here, we show that neural stem cells (NSCs) derived from CRISRP/Cas9‐edited human‐induced pluripotent stem cell (hiPSC) expressing a suicide gene had higher tumor‐trophic migratory capacity compared with mesenchymal stem cells (MSCs), leading to marked in vivo antitumor effects. High migratory capacity in iPSC‐NSCs was related to self‐repulsive action and pathotropism involved in EphB‐ephrinB and CXCL12‐CXCR4 signaling. The gene insertion to ACTB provided higher and stable transgene expression than other common insertion sites, such as GAPDH or AAVS1. Ferroptosis was associated with enhanced antitumor immune responses. The thymidylate synthase and dihydroprimidine dehydrogenase expressions predicted the treatment efficacy of therapeutic hiPSC‐NSCs. Our results indicate the potential benefit of genome‐edited iPS cells based gene therapy for invasive GSCs. Furthermore, the present research concept may become a platform to promote clinical studies using hiPSC.
Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
Authors: Zheng Shaokai , Obrist Dominik , Burkhard Fiona , Clavica Francesco 
Published: September 2022

AbstractUreteral stents are indispensable devices in urological practice to maintain and reinstate the drainage of urine in the upper urinary tract. Most ureteral stents feature openings in the stent wall, referred to as side holes (SHs), which are designed to facilitate urine flux in and out of the stent lumen. However, systematic discussions on the role of SH and stent lumen size in regulating flux and shear stress levels are still lacking. In this study, we leveraged both experimental and numerical methods, using microscopic‐Particle Image Velocimetry and Computational Fluid Dynamic models, respectively, to explore the influence of varying SH and lumen diameters. Our results showed that by reducing the SH diameter from to the median wall shear stress levels of the SHs near the ureteropelvic junction and ureterovesical junction increased by over , even though the flux magnitudes through these SH decreased by about . All other SHs were associated with low flux and low shear stress levels. Reducing the stent lumen diameter significantly impeded the luminal flow and the flux through SHs. By means of zero‐dimensional models and scaling relations, we summarized previous findings on the subject and argued that the design of stent inlet/outlet is key in regulating the flow characteristics described above. Finally, we offered some clinically relevant input in terms of choosing the right stent for the right patient.
Who really needs a Metaverse in anatomy education? A review with preliminary survey results
Authors: Iwanaga Joe , Muo Edward C. , Tabira Yoko , Watanabe Koichi , Tubbs Susan J. , D'Antoni Anthony V. , Rajaram‐Gilkes Mathangi , Loukas Marios , Khalil Mohammed K. , Tubbs R. Shane 
Published: September 2022

AbstractThe term Metaverse (“meta” defined as beyond, transcendence or virtuality, and “verse” meaning universe or world) denotes a “virtual reality space” for anatomy teaching. To ascertain how many anatomists are familiar or are using this adjunct in teaching, we conducted a short survey at the 2022 annual meeting of the American Association of Clinical Anatomists (AACA). Interestingly, only six respondents (9.4%) had used a Metaverse for teaching anatomy. Moreover, the vast majority of attendees were anatomy educators or basic science faculty, but not practicing physicians/surgeons or other actively practicing health care professionals; a group where this technology has been used much more commonly. The present manuscript was authored by anatomy educators, practicing physicians and other actively practicing health care professionals with backgrounds in diverse medical fields, that is, anatomists, medical doctors, physician assistants, dentists, occupational therapists, physical therapists, chiropractors, veterinarians, and medical students. Many of these authors have used or have been exposed to a Metaverse in the clinical realm. Therefore, the aim of the paper is to better understand those who are knowledgeable of a Metaverse and its use in anatomy education, and to provide ways forward for using such technology in this discipline.
Combining expression of RNF43 and infiltration level of CD163+ tumor associated macrophage predicts prognosis of clear cell renal cell carcinoma
Authors: Zhu Dawei , Shi Xiaokai , Tian Yijun , Li Hao , Tang Bowen , Zhang Ziyi , Zhang Ze , Zuo Li 
Published: September 2022

AbstractSearching for reliable indicators for evaluating prognosis diagnosed with clear cell renal cell carcinoma (ccRCC) is crucial for improving clinical therapies. However, current researches have looked mainly at the prognostic value of a single intratumoral indicator, neglecting tumor‐infiltrating immune cells (TIICs) in the microenvironment. This study examined whether the integration of Ring finger protein 43 (RNF43) expression and CD163+ tumor‐associated macrophage (TAM) infiltration in combination with clinical indexes forecast ccRCC patient outcome with relatively high accuracy. Firstly, the expression of RNF43 and CD163 were detected with immunohistochemistry. Totally, 346 ccRCC patients were random separated evenly into training and validation datasets to make further analyses. We found that RNF43 expression was negatively correlated with infiltration level of CD163+ TAM in ccRCC, which was closely associated with the TNM stage and outcome of these patients. The multiple regression analysis demonstrated that RNF43, CD163, and TNM stage could function as independent risk factors in overall survival (OS) and progression‐free survival (PFS) prediction of ccRCC. Furthermore, a better postoperative prognosis index for ccRCC patients was obtained by combining RNF43 and CD163+ TAMs, which assessed with time‐dependent C‐index analyses and a nomogram. Consequently, combining RNF43 and CD163+ TAMs along with TNM stage acquired robust accuracy in forecasting outcome of patients with ccRCC. In conclusion, combining intratumoral RNF43 expression, CD163+ TAM infiltration, and TNM stage could significantly enhance the veracity in forecasting postoperative outcomes.
How short film ads improve brand attitudes: The roles of viewing experiences and consumption visions
Authors: Chang Chingching 
Published: September 2022

AbstractThis article proposes a model to predict how the content of short film ads might trigger hedonic and eudaimonic experiences, which then contribute to positive changes in attitudes toward the sponsoring brand, through two processes. In the first process, people seek branded entertainment to break away from their mundane reality. The ultimate purpose is to enjoy hedonic experiences, as might be triggered by a funny plot that induces perceptions of humor, which in turn can evoke positive affect. In the second process, consumers search for meaning through vicarious experiences, which enable them to achieve personal growth. In this process, the purpose is to find meaning or acquire eudaimonic experiences. Because a meaningful story plot explicitly encourages consumers to reflect on their lives, it helps them feel inspired and develop sentimental feelings, thus leading to eudaimonic experiences. The proposed dual process model suggests that gratification derived from viewing short film ads, due to hedonic or eudaimonic experiences, can prompt positive brand attitude changes. Moreover, consumption visions triggered by short films contribute to product changes; they moderate the first process but not the second.
The Oscars: Friends and foes for millennials
Authors: Fine Monica B. , Gironda John T. , Petrescu Maria , Dobre Costinel 
Published: September 2022

AbstractThis study uses a multi‐method approach to formulate a theoretical framework of movie experience evaluation based on Millennials' perceived quality of the Academy Awards and the event's relevancy concerning movie characteristics, social media usage, and eWOM‐giving. The paper is based on a conceptual framework that theorizes movies as experiences and on the service quality framework. Using national consumer survey data, we present the results of a qualitative conceptual mapping analysis focused on the themes identified by Millennials as recommendations for the Academy Awards to relate and appeal to moviegoers in their age group. The variables that affect Millennial consumers' perceived quality of the Oscars are examined further utilizing a fuzzy‐set qualitative comparative analysis (fsQCA). The qualitative and quantitative analyses expose the complexity of service, experience, and social factors contributing to Millennials' attitudes towards the Academy Awards and the combination of cues consumers use when evaluating movie experiences: objective features and socially related aspects, reference groups, and indirect traits, such as involvement in social causes.
Annual Phytochemical Variations and Antioxidant Activity within the Aerial Parts of Lavandula angustifolia, an Evergreen Medicinal Plant
Authors: Najafian Sharareh , Afshar Mahmoud , Radi Mohsen 
Published: September 2022

AbstractAcknowledging the importance of medicinal compounds, flavonoids, and phenolic acids in plants and human health; understanding the best time to harvest plants to get the most potentially therapeutic biological activity; and predicting and controlling the quality of medicinal plants are very useful. The rich chemical composition of medicinal lavender, as well as its antioxidant activity, has led to its wide application in the pharmaceutical, cosmetic, and food industries. In the current research, seasonal differences in phenolic content; the main constituents of essential oil, essential oil yield, and antioxidant activity; and flavonoid content were evaluated. In this investigation, for all the investigated factors, three replications were considered as completely randomized designs. The predominant natural components were α‐pinene, camphene, 1,8‐cineole, limonene, camphor, borneol, cryptone, isobornyl formate, cumin aldehyde, carvone, caryophyllene oxide, and epi‐α‐cadinol. The highest rate of 1,8‐cineole was seen in summer, while camphor and borneol showed their highest percentages in the cold season. Some of the compounds such as caryophyllene oxide, isobornyl formate, and cumin aldehyde showed their highest amounts in the spring with the activation of some important plant enzymes such as peroxidase. The total content of flavonoids and some phenolic compounds (coumarin and p‐coumaric acid) increased when plants received sunlight for a longer time than in the colder to warmer seasons. On the other hand, increases in chlorogenic acid and vanillin were observed in spring. Also, the highest antioxidant activity was observed in lavender, which was accompanied by an increase in the important phenolic composition of rosmarinic acid in the cold season. Generally, this investigation provides beneficial evidence about the most appropriate harvest time for lavender to produce the most favorable constituents for optimization in food, pharmaceutical, and herbal products.
Contemporary diagnosis and management of severe tricuspid regurgitation
Authors: Zahr Firas , Chadderdon Scott , Song Howard , Sako Edward , Fuss Cristina , Bailey Steven R. , Cigarroa Joaquin 
Published: September 2022

AbstractMany novel percutaneous interventions are being developed for application in the tricuspid valve position. At the present time in the United States, there are no commercially available transcathter devices for this application. This article reviews the growing evidence for diagnosing, imaging, and treating severe tricuspid regurgitation as well as the surgical and transcatheter options that are under current development and in various stages of clinical trials.
First case of sunflower pattern calcific deposits and posterior capsular opacification on a pseudophakos
Authors: Kaur Kirandeep , Mishra Snigdha , Gurnani Bharat 
Published: September 2022

AbstractCalcification of the intraocular lens is an uncommon phenomenon that usually follows an uncomplicated surgery. Here, the authors report the first case of a 66‐year‐old male patient who presented with defective vision and was diagnosed with sunflower pattern calcific deposits and Elschnig pearl pattern posterior capsular opacification in the right eye.
Synergistic Electrocatalytic Syngas Production from Carbon Dioxide by Bi‐Metallic Atomically Dispersed Catalysts
Authors: Delafontaine Laurent , Murphy Eamonn , Guo Shengyuan , Liu Yuanchao , Asset Tristan , Huang Ying , Chen Jiazhe , Zenyuk Iryna V. , Pan Xiaoqing , Atanassov Plamen 
Published: September 2022

AbstractThe production of syngas by traditional processes such as steam methane reforming is energetically intensive and produces a large amount of CO2 emissions. In contrast, the electrochemical CO2 reduction reaction (CO2RR) enables the carbon neutral production of syngas at ambient conditions. Among non‐precious metal catalysts, metal‐nitrogen‐carbon electrocatalysts are inexpensive and highly selective towards syngas production. This study examined the selectivity of mono‐ and bi‐metallic (M−N−C, M=Fe, Mo or FeMo) electrocatalysts towards syngas production. The ratio of the CO : H2 in the syngas was tuned by modifying the ratio of the metallic precursors in the bi‐metallic FeMo−N−C catalysts, tailoring the catalysts’ selectivity towards the CO2RR or the hydrogen evolution reaction (HER). The catalyst synthesis temperature(s) were considered as they influence the catalyst morphology and activity. Further, the dependence of the ratio of CO : H2 in the syngas as a function of the potential was explored for the different bi‐metallic catalysts. This work showed that by tailoring both the ratio of Fe : Mo in the bi‐metallic catalyst and optimizing the reductive potential, a CO : H2 ratio between 0.25 to 5 was achievable. This study demonstrated a novel approach in which the ratio of the product syngas composition could be tailored in a single reaction, without the need for further downstream processing to reach a desired composition.
Piezoelectrically Mediated Reactions: From Catalytic Reactions to Organic Transformations
Authors: Ren Ziye , Peng Yuhao , He Hanliang , Ding Chengqiang , Wang Jialin , Wang Zhao , Zhang Zhengbiao 
Published: September 2022

Comprehensive SummaryRecently, piezocatalysis has attracted considerable attention as a new type of renewable mechanical energy conversion technology, which relies on the strain induced polarization of the piezoelectric material. This new technology has been extensively applied in the applications of water splitting, water remediation, gas purification and tumor therapy. Despite the rapid development in the piezocatalysis, the utilization of piezoelectric materials for synthetic purpose is still under exploration. Piezoelectric means to promote organic reactions expand the scope of piezoelectrically mediated reactions and show successes in both organic and polymer synthesis. Herein, we provide a comprehensive review on recent progress of piezoelectrically mediated reactions, catalytic mechanisms and applications in the last few years. The limitations and future directions of this area are also discussed. We believe this review will provide new insights into the underlying mechanism of piezoelectric mediated electron transfer process and guide the design of new chemistry.
The Key Role of Subtle Substitution for a High‐Performance Ester‐Modified Oligothiophene‐Based Polymer Used in Photovoltaic Cells
Authors: Li Sunsun , Ding Yuan , Xu Lei , Zhao Wenchao , Zhang Jianqi , Qin Jinzhao , Zhang Yuyang , Zhao Jingjing , He Chang , Peng Qiming , Hou Jianhui 
Published: September 2022

Comprehensive SummaryIn organic solar cells (OSCs), developing high‐performing easily synthesized photoactive materials is essential for pursuing cost‐ effective balance. Herein, we have designed and synthesized a pair of wide‐band‐gap polymers (PBDE4T‐0F and PBDE4T‐2F), using the low synthesis cost dicarboxylic ester‐substituted quaterthiophene as the building block. Despite the minor change of molecular structure for polymer PBDE4T‐xF, the fluorine substituent in polymer PBDE4T‐2F greatly enhances its interchain aggregation. The higher aggregation tendency of ester‐modified polymer in solution is beneficial for reducing both the aggregate size and π‐π stacking distance of blend film, which contribute to the highly efficient exciton dissociation and symmetric charge transport. An impressive power‐conversion efficiency (PCE) of 16.1% is achieved for the PBDE4T‐2F:BTP‐eC9‐based device, while its counterpart only delivers a PCE of 5.8% with distinctly lower short‐circuit current density (Jsc) and fill factor. Notably, the aggregation effect of donor polymer has also been found to be associated with the energy level shifts, and thus the variation of charge transfer energy and voltage losses for blend system. The results suggest that simultaneously reduced voltage loss and increased Jsc can be expected by further finely tuning the aggregation behavior of the ester‐modified oligothiophene‐based donor polymer.
Kinetics of Catalyzed Thermal Degradation of Polylactide and Its Application as Sacrificial Templates†
Authors: Feng Li , Cui Chenhui , Li Zhen , Zhang Mengyuan , Gao Shenghui , Zhang Qiang , Wu Youshen , Ge Zhishen , Cheng Yilong , Zhang Yanfeng 
Published: September 2022

Comprehensive SummaryPolylactide (PLA) is an outstanding sacrificial template material for the manufacture of microchannels in a thermosetting matrix. However, the initial thermal degradation temperature of pure PLA is relatively high (about 280°C), which limits its use as a sacrificial template. In this report, we found that TBD, an organic base catalyst, can significantly reduce the thermal degradation temperature of PLA. TBD has higher catalytic activity for the thermal degradation of PLA compared with Tin(II) oxalate (Sn(Oxa)), one catalyst reported in the literature. Moreover, the gaseous products catalyzed by TBD for PLA thermal degradation are mainly lactide, and the formation temperature of the monomer is lower and the yield is higher, which may have potential value for PLA recycling. A combined catalyst, S8T2, was composed of 80% low activity catalyst Sn(Oxa) and 20% high activity catalyst TBD, which can catalyze the rapid degradation of PLA without greatly damaging the mechanical properties of PLA. PLA‐S8T2 sacrificial fibers can form high‐precision one‐dimensional microchannels in the epoxy resin matrix, and 3D‐printed PLA‐S8T2 sacrificial templates can be used to form three‐dimensional microchannels in a thermosetting matrix by vaporization of sacrificial components process (VaSC). These features highlight the great potential of PLA‐S8T2 as sacrificial template material for the preparation of the complicated microchannels in the thermosetting matrix.
The role of coronary artery calcium in allocating pharmacotherapy for primary prevention of cardiovascular disease: The ABCs of CAC
Authors: Maniar Yash , Blumenthal Roger S. , Alfaddagh Abdulhamied 
Published: September 2022

AbstractDetermining optimal candidates for the numerous potential pharmacotherapies for primary prevention of atherosclerotic cardiovascular disease remains challenging. Selective use of coronary artery calcium (CAC) scoring is recommended by the 2018 and 2019 American Heart Association/American College of Cardiology Cholesterol and Primary Prevention Guidelines as a tool for refining cardiovascular disease risk assessment. A growing body of research shows that CAC has potential value in allocation of primary prevention aspirin, determining blood pressure targets and treatment intensity, the intensity of cholesterol management, and use of the more expensive medications for type 2 diabetes. We also review the literature regarding very elevated CAC scores greater than 400 or 1000 and how these scores appear to confer a risk for cardiovascular disease on par with secondary prevention cohorts.
Effect of Protonation and Deprotonation on Electron Transfer Mediated Decay and Interatomic Coulombic Decay
Authors: Kumar R. , Vaval N. 
Published: September 2022

AbstractElectronically excited atoms or molecules in an environment are often subject to interatomic/intermolecular Coulombic decay (ICD) and/or electron transfer mediated decay (ETMD) mechanisms. A few of the numerous variables that can impact these non‐radiative decay mechanisms include bond distance, the number of nearby atoms or molecules, and the polarisation effect. In this paper, we have studied the effect of protonation and deprotonation on the ionization potential (IP), double ionization potential (DIP), and lifetime (or decay width) of the temporary bound state in these non‐radiative decay processes. We have chosen LiH‐NH3 and LiH‐H2O as test systems. The equation of motion coupled cluster singles and doubles method augmented by complex absorbing potential (CAP‐EOM‐CCSD) has been used in calculating the energetic position of the decaying state and the system's decay rate. Deprotonation of LiH‐NH3/LiH‐H2O either from the metal center (LiH) or from ammonia/water lowers the IP and DIP compared to the neutral systems. In contrast, protonation increases these quantities compared to neutral systems. The protonation closes the inner valence state relaxation channels for ICD/ETMD. For example, the decay of the O‐2s/N‐2s state stops in protonated systems (LiH2+‐H2O, LiH2+‐NH3, and LiH‐NH4+). Our study also shows that the efficiency, i. e., the rate of ICD/ETMD, can be altered by protonation and deprotonation. It is expected to have implications for chemical and biological systems.
Recovery of High Concentrations of Phosphorus and Ammonium through Struvite Crystallization by CO2 Repelling
Authors: Korchef Atef , Naffouti Saoussen , Souid Imen 
Published: September 2022

AbstractStruvite (MgNH4PO4·6H2O) can precipitate from wastewater thereby recovering both ammonium and phosphorus while simultaneously producing a valuable fertilizer. In the present work, the precipitation of struvite by CO2 repelling at initial constituent ions concentrations in the range between 123.89 and 800 mg L−1 and different airflow rates is investigated. Struvite precipitation is induced by an increase of the solution supersaturation occurring concurrently with the removal of the dissolved CO2 from the solution. The precipitates obtained are characterized by powder X‐ray diffraction and scanning electronic microscopy. For all experiments, struvite is the only phase observed. Whatever the airflow used, the precipitation pH decreases with increasing the initial phosphorus concentration. Struvite precipitates at supersaturations in the range 6–18 and pH in the range 6.5–8.5. High phosphorus removal efficiencies (>70%) are obtained at high struvite supersaturations. The increase in the airflow rate results in a significant decrease in the phosphorus removal efficiency. When the initial phosphorus concentration increases, the particle size distribution becomes monomodal covering a broad range of particle sizes up to 140 µm. This is of utmost importance since larger struvite crystals are easier to separate from the liquid phase and release ammonium and phosphorus from struvite faster, promoting the use of struvite as a fertilizer.