bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the effects of lipoic acid and dihydrolipoate on experimental renal ischemia-reperfusion model
Authors: KAÇMAZ Filiz , OZCAN Oguzhan , ARPACI Abdullah , AYAZ Ercan , BAYRAKTAR Hamdullah Suphi , GÖRÜR Sadık 
Published: May 2022

Objective: Ischemic/reperfusion (I/R) causes tissue injury and the leading cause of acute kidney injury. In this study, we aimed to investigate the effects of the long and short-term usage of ALA and short-term DHLA on oxidative stress markers in the experimental renal ischemia-reperfusion model.
Methods: Forty male rats (250 to 300 gr) were divided into 5 groups: control; I/R group; long-term ALA+IR group; short-term ALA+IR group; and short-term DHLA+IR group. Ischemia was carried out for 45 minutes followed by reperfusion for 4 hours. Thiobarbituric acid reactive sunstances (TBARM), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in tissue samples and serum total antioxidant status (TAS) and total oxidative stress (TOS) assayed by the spectrophotometrically. Tissue samples were investigated by histopathological analyzes.
Results: TBARM (Control: 0.38±0.05. I/R: 1.37±0.17, long-term ALA-treated group:1.025±0.15, short-term ALA-treated group: 0.68±0.09, short-term DHLA-treated group: 0.38±0.04 (nmol/mg protein); p
STUDYING THE QUALITY OF LIFE OF PATIENTS USING OVERLAPPING PROSTHESES
Authors: Khomenko Ivan 
Published: May 2022

Subject. The article provides an analysis of the indicators of life quality of patients after prosthetic treatment. The study included patients with overlapping prostheses based on dental implants and tooth roots. Patients were divided into main and control groups.
Aim – to analyze the quality of life of patients after prosthetic treatment using overlapping prostheses.
Methodology. We conducted prosthetic treatment of 45 patients among them, 19 men and 26 women, aged from 45 to 72 years. Overlapping prostheses based on dental implants were made for patients of the main group. Overlapping prostheses based on the restored tooth roots were made for patients of the control group. We analyzed the quality of life of patients of the main and control groups after prosthetic treatment based on the results of survey. The OHIP-14 method for determining the quality of life in dental patients was used.
Results. After prosthetic treatment of patients of the main group using overlapping dentures based on dental implants, the results of study of life quality were 17.1 ± 2.7. One month after prosthetic treatment, patients in the control group, according to the results of the questionnaire, had quality of life indicators of 18.1 ± 3.9. Orthopedic treatment of patients using overdentures is a modern and effective method. The use of dental implantation in the patients of the main group and the restoration of the roots of the teeth in the patients of the control group to support the overdentures made it possible to achieve optimal results.
Conclusions. The use of overlapping dentures based on dental implants and restored tooth roots improves the quality of life of patients.
MICROCIRCULATORY DISORDERS OF ALVEOLAR PROCESS MUCOSA IN PATIENTS WITH DRUG-ASSOCIATED OSTEONECROSIS OF THE JAW
Authors: Vinogradova Natal'ya , Haritonova Marina , L'vov Konstantin 
Published: May 2022

The research is relevant due to the widespread use of osteomodifying agents among patients with bone metastases with malignant neoplasms of various localization. The healing process is sluggish due to the toxic effect of these medications, including their influence on soft tissues; it often occurs that relapse sets in after surgical treatment. The research aims to study possible variants and degree of mucosa microcirculation disorders of the alveolar processes among patients with drug-associated osteonecrosis of the jaw. Materials and methods of the research. Microcirculation was examined with the method of Laser Doppler flowmetry (LDF) with the LAKK-OP analyzer (modification 1) (SPE “LAZMA” Ltd, Moscow). The patients diagnosed with drug-associated osteonecrosis of the jaw were examined for microcirculation by Laser Doppler flowmetry method in the lesion and at the side with no visible clinical manifestations. The exclusion criterion was the patient’s general medical condition with the score no less than three on the EGOC scaling. The comparison group included practically healthy volunteers. The exclusion criteria were complete secondary adentia, heart defects, hypertension, vascular pathology, diabetes mellitus, cancer, bronchial asthma, chronic obstructive pulmonary disease, maxillofacial inflammatory diseases, HIV infection.
Results. The perfusion index among the patients with drug-associated osteonecrosis of the jaw was lower by 0.65 pf. units (17,53 ± 4,04 pf. units) in the lesion and by 2,14 pf. units (16,14 ± 3,23 pf. units) at the side with no visible clinical manifestation compared to the healthy group (18,18 ± 6,24 pf. units). The average amplitude of myogenic oscillations in the main group (3,24 ± 2,08 pf. units) was higher than the oscillation indices of different origin; on the contrary, in the comparison group, as well as in the healthy part of the main group, the amplitude of neurogenic oscillations prevailed (1,64 ± 0,91 pf. units and 3,41 ± 1,53 pf. units). Conclusion. The research reveals impaired microcirculation symptoms of the ischemic-stagnant type, both in the lesion and at the side with no visible clinical manifestations, which indicates a system failure of the mucous membrane of alveolar processes among these patients.
Extension spatio-temporelle du modèle chèvre INRA 2018 : 2. L'évolution de la dynamique des réserves, du poids vif et de la NEC sur un cycle productif
Authors: SAUVANT Daniel , PUILLET Laurence , BLUET Bertrand 
Published: May 2022

L'objectif de ce travail était de simuler les évolutions du Poids Vif (PV), de ses composantes (ex. les réserves corporelles) et de la Note d'État Corporel (NEC) des chèvres sur un cycle de production en s'appuyant sur les relations dynamiques du modèle nutritionnel caprin INRA 2018. Dans un premier temps, l'approche a considéré de façon distincte les phénomènes de changement de poids vif liés à la lactation, la gestation et la croissance. En effet, la nature des informations disponibles a priori et les démarches calculatoires n'étaient pas les mêmes pour ces trois états physiologiques. Pour les situations considérées, un modèle original d'évolution des contenus digestifs au cours d'un cycle productif a été développé pour aboutir à des évolutions du PV et du PV vide (PVV), défini comme le poids maternel hors contenus digestifs et utérus gravide. Pour la lactation, la démarche a consisté à utiliser les équations de la dynamique des réserves énergétiques pour déterminer les bilans énergétiques cumulés puis les cinétiques de PVV, en intégrant l’effet du potentiel de production laitière. Pour la gestation, l’approche a consisté à utiliser les cinétiques de PV puis de PVV, pour distinguer la cinétique pondérale de l'utérus gravide, fonction de la prolificité, et la cinétique pondérale de l'organisme maternel seul. Pour ce dernier, une approche originale a permis d’estimer l'anabolisme maternel en début de gestation et le catabolisme en seconde partie de gestation en intégrant l’effet de la prolificité. Les cinétiques de PV et PVV au cours des trois états physiologiques ont été combinées pour prédire la cinétique globale sur un cycle productif. Il a ainsi été possible de proposer une méthode d'estimation des cinétiques de PV à partir de la donnée du « poids vif format » (PVF correspondant au PV minimal atteint pendant un cycle productif). Enfin, la prédiction des cinétiques des NEC a été possible grâce aux relations disponibles entre la NEC sternale et la teneur en lipides corporels, ainsi qu’entre les NEC sternales et lombaires. Les évolutions de la NEC ont été calculées en séparant les phases de lactation, croissance et gestation, en particulier pour s'appuyer sur l'évolution de l'organisme maternel indépendamment de celle de l'utérus gravide. Ce modèle a été intégré dans le module « chèvres laitières » du logiciel de rationnement INRAtion®V5 – Rumin’Al afin de pouvoir tracer les dynamiques d'évolution du PV et de la NEC correspondant au potentiel des animaux afin de les comparer aux valeurs réelles.
The mite Acarus farris inducing defensive behaviors and reducing fitness of termite Coptotermes formosanus provides a case for phoresy as a precursor to parasitism
Authors: Chen Yong , Zhang Lijun , Zhang Shijun , Liu Bingrong , Zeng Wenhui , Li Zhi-Qiang 
Published: May 2022

Abstract
Background: The ecology and evolution of phoretic mites and termites have not been well studied. In particular, it is unknown whether the specific relationship between mites and termites is commensal or parasitic. High phoretic mite densities have often been found to occur in weak termite colonies, suggesting that the relationship is closer to that of parasitism than commensalism. Results: To examine this, Coptotermes formosanus was used as a carrier, and Acarus farris as the phoretic mite. We used video recordings to observe termite social immunity behaviors and bioassay to examine termite fitness. Our results showed that the attachment of the mite on the termite can enhance termite social immunity behaviors like alarm vibration and grooming frequency while decreasing the duration of individual grooming episodes in phoretic mites. Further, A. farris phoresy led to a 22.91% reduction in termite abdomen volume and a 3.31-fold increase in termite mortality. Conclusions: Phoretic behavior hastened termites’ death, and helped propagate the population of mites feeding on dead termites. Frequent social behaviors may cost termites energy, and thus provides a case for phoresy being a precursor to parasitism. The specific relationship between A. farris and C. formosanus is closer to parasitism than to commensalism.
Prevalence and Incidence of carbapenem-resistant K. pneumoniae colonization: systematic review and meta-analysis
Authors: Tesfa Tewodros , Mitiku Habtamu , Edae Mekuria , Assefa Nega 
Published: May 2022

Abstract
Background: Klebsiella pneumoniae is a gram-negative rod belonging to the order Enterobacterales and having a wide distribution in the environment, including the human colon. Recently the bacterium is one of the known problems in the healthcare setting as it has become resistant to last-resort drugs like carbapenems. The colonized person can serve as a reservoir for his/herself and others, especially in the healthcare setting leading to nosocomial and opportunistic infections. Therefore, we aimed to quantitatively estimate the rate of prevalence and incidence of colonization with carbapenem-resistant K. pneumoniae.Methods: A literature search was conducted on PubMed/MEDLINE, Google Scholar, Science Direct, Cochrane Library, WHO Index Medicus, and others. All studies (published and unpublished) addressing the prevalence/ incidence of K. pneumoniae colonization were included in the study. Data were extracted onto format in Microsoft Excel and pooled estimates with 95% confidence interval calculated using Der-Simonian-Laird random-effects model. The degree of heterogeneity was presented with I2 statistics and prediction intervals. Publication bias was presented with funnel plots of standard error supplemented by Egger's tests. Results: A total of 35 studies were included in the review and 32 records with 37,661 patients for assessment of prevalence while ten studies with 3643 patients were used for incidence of colonization. The prevalence of colonization with carbapenem-resistant K. pneumoniae ranges from 0.13% to 22% with variation in different localities with a pooled prevalence of 5.43% (3.73-7.42). Whereas the incidence of colonization ranges from 2% to 73% with a pooled incidence of 22.3% (CI: 12.74-31.87), both prevalence and incidence reports are majorly from developed countries. There was a variation in the distribution of carbapenem resistance genes among colonizing isolates with KPC as a major gene reported from many studies and NDM being reported mainly by studies from Asian countries. A univariate meta-regression analysis indicated continent, patient type, study design, and admission ward do not affect the heterogeneity (p-value>0.05).Conclusion: The review revealed that colonization with K. pneumoniae is higher in a healthcare setting with variable distribution in different localities, and resistance genes for carbapenem drugs also have variable distribution in different geographic areas.
Estimation and Optimization of Relative Dielectric Constant of Medium and Low Loss Dielectric Objects at Ka and mm-Wave Band Frequencies
Authors: Pradhan Ayan Kanti , Maiti Shubhendu , Biswas Salil Kumar , Mondal Sanjay , Maiti Manabendra , Bhattacharyya Kausik 
Published: May 2022

Abstract
A novel technique based on cavity perturbation for the characterization of dielectric properties of medium and low loss homogeneous cylindrically shaped materials using a single iris coupled rectangular resonator in Ka and millimeter-wave band frequencies is presented in this paper. The relative real permittivity and the dielectric loss have been calculated from the formulated analytical equations using the simulation measurements of unperturbed and loaded cavity resonators. Simulated results demonstrate degradation in accuracy of the derived relative dielectric constant at higher-order sample radius. Finally, a first-order correction factor has been applied to stabilize the derived dielectric permittivity of selective dielectric samples measured at two respective frequencies, 36.624 GHz and 52.263 GHz. Using this modification stable and optimized dielectric constant of any dielectric types with extended operating radius can be obtained with a high degree of absolute accuracy. And thus the restrictions imposed by different cavity based measurement techniques on the selection of precise sample dimensions can be resolved.
Mechanical Hyperinflation Maneuver and intracranial pressure of critical neurological patients: protocol for a randomized clinical trial.
Authors: SOUZA DANIELA , Branco Marina Wolff , Junior Hipólito Carraro , Zocolotti Ana Márcia Delattre , Takeda Sibele Yoko Mattozo , Valderramas Silvia 
Published: May 2022

Abstract
Background: Mechanical Hyperinflation Maneuver (MHM) is a technique known for optimizing bronchial hygiene and respiratory mechanics, however its effects on intracranial pressure are not known. Methods: 48 patients aged ≥ 18 years, with clinical diagnosis of acute stroke, confirmed by neuroimaging examination, with onset of symptoms within 72 hours, under mechanical ventilation through tracheal tube, will participate in this study. Participants will be randomly allocated into 2 groups: Experimental Group (n=24): MHM plus tracheal aspiration, and Control Group (n=24): tracheal aspiration only. Intracranial pressure will be measured by a non-invasive technique using Brain4care BcMM-R-2000 sensor. This will be the primary outcome. Results will be recorded at 5 times: T0 (start of monitoring), T1 (moment before MHM), T2 (moment after the MHM and before tracheal aspiration), T3 (moment after tracheal aspiration), T4 and T5 (monitoring 10 and 20 minutes after T3). Secondary outcomes are respiratory mechanics and hemodynamic parameters. Discussion: This study will be the first clinical trial to examine the effects and safety of MHM on intracranial pressure measured by non-invasive monitoring. Limitation includes the impossibility of blinding the physical therapist who will supervise the interventions. It is expected with this study to demonstrate that MHM can improve respiratory mechanics and hemodynamic parameters, and provide a safe intervention with no changes in intracranial pressure in stroke patients.Trial registration: Brazilian Clinical Trial Registry (RBR – 5qs9k2n). Registered on 27 July 2021. https://ensaiosclinicos.gov.br/rg/RBR-5qs9k2nProtocol version 1.0, protocol date March, 2019.
Multiresolution Spectrally Encoded Terahertz Reflection Imaging Through a Highly Diffusive Cloak
Authors: Ebrahimkhani Mahmoud , Harris Zachery , Liu Mengkun , Arbab M. Hassan 
Published: May 2022

Abstract
Turbid media are usually made of wavelength-scale inhomogeneous granular particles, which give rise to many significant imaging challenges. The random variation of the refractive index within such media distorts the spherical beam wavefronts, resulting in smeared and speckly images. The light scattering also limits the depth of focus to only few multiples of the scattering mean free path. Additionally, the scattering-induced spectral artifacts obscure the fingerprints of the chemicals in a sample, preventing accurate imaging and identification of the materials cloaked under a highly diffusive medium. We present the implementation of a multiresolution spectral analysis technique by decomposing the reflection spectrum using a wavelet transform approach for creating spatially- and spectrally-resolved chemical maps through such scattering media. We define a new spectroscopic concept, dubbed the "bimodality coefficient spectrum" of a sample, and show that the broadband wavelet-based reconstruction of the bimodality coefficient spectrum can resolve the signature resonant frequencies through scattering layers. We show that our new approach can achieve spectral images with diffraction-limited resolution. This technique can be used for stand-off detection of materials and spectral imaging in nondestructive testing and biological applications.
Downregulation of circBIRC6 and circCORO1C during differentiation of human cord blood-derived CD34 cells
Authors: Karimi Roqaye , Atashi Amir , Zomorrod Mina Soufi , Agami Monireh , Ajami Mansoureh 
Published: May 2022

Abstract
Umbilical cord blood hematopoietic stem cells (UCB HSCs) transplantation has attracted the attention of many researchers due to the low probability of GVHD and HLA mismatching; however, the use of this resource for adults has been limited due to the inadequate number of CD34+ HSC from any individual donor. Recent reports indicate that circular RNAs (circRNAs) are involved in stem cell properties. In this study, the functional role of several candidate circRNAs, including circCORO1C and circBIRC6 in CD34+ HSCs was investigated. The results showed that the expression levels of circBIRC6 and circCORO1C and simultaneously, the expression of transcription factors such as NANOG and SOX2 were significantly downregulated during differentiation. Taken together, these findings suggested that circBIRC6 and circCORO1C were involved in the process of self-renewal of CD34+ HSCs, and their expression is downregulated by differentiating these cells.
Genetic and transcriptomic dissection of an artificially induced paired spikelet mutant of wheat (Triticum aestivum L.)
Authors: Zhang Juanyu , Tang Yanyan , Pu Xi , Qiu Xuebing , Wang Jinhui , Li Tao , Zhou Yao , Chang Yuxiao , Liang Junjun , Zhang Haili , Deng Guangbing , Long Hai 
Published: May 2022

Abstract
Grain yield of wheat is significantly associated with inflorescence or spike architecture. However, few genes related to wheat spike development have been identified and their underlying mechanisms are largely unknown. In this study, we characterized an ethyl methanesulfonate (EMS)-induced wheat mutant, wheat paired spikelets 1 (wps1). Unlike a single spikelet that usually develops at each node of rachis, a secondary spikelet appeared below the primary spikelet at most of the rachis nodes of wps1. The microscope observation showed that the secondary spikelet initiated later than the primary spikelet. Genetic analysis suggested that the PS of wps1 is controlled by a single dominant nuclear gene, designated WHEAT PAIRED SPIKELETS 1 (WPS1). Further RNA-seq based bulked segregant analysis and molecular marker mapping localized WPS1 in a interval of 208.18Mb-220.92Mb on the chromosome arm 1DL, which is different to known genes related to spike development in wheat. By using wheat omics data, TraesCS1D02G155200 encoding a HD-ZIP III transcription factor was considered as a strong candidate gene for WPS1. Transcriptomic analysis indicated that PS formation in wps1 is associated with auxin-related pathways and may be regulated by networks involving TB1, Ppd1, FT1, and VRN1, etc. This study laid the solid foundation for further validation of the causal gene of WPS1 and explore its regulatory mechanism in PS formation and inflorescence development, which may benefit to kernel yield improvement of wheat based on optimization or design of spike architecture in the future.
A memristor crossbar based on a novel ternary memristor model
Authors: Wang Xiaoyuan , Zhou Jiawei , Dong Chuantao , Jin Chenxi , Eshraghian Jason K. , Iu Herbert Ho-Ching , Kang Sung Mo 
Published: May 2022

Abstract
In this paper, a high-density programmable logic array based on a ternary memristor crossbar array is designed. Based on the three-valued state characteristics of the ternary memristor, we implement the ternary-OR logic gate and a standard ternary inverter to demonstrate the application of this proposed crossbar by using reconfigurable and programmable connections of the memristor cells in the array. Subsequently, on the basis of these logic gates, ternary NAND gates, NOR gates, XOR gates and XNOR gates are further realized. The above-mentioned logic gates all use memristance as the logic state variable. SPICE simulations are conducted to verify the functionality of the programmable gate array based on the proposed ternary memristor crossbar.
A New Formal Approach for Performance Evaluation of Green MAC Protocol in Energy Harvesting WSNs
Authors: Siham Zroug , Kahloul Laid , Tigane Samir , Hamani Nadia , Banharzallah Saber 
Published: May 2022

Abstract
Wireless Sensor Networks (WSNs) are intrinsically energy-constrained networks. Researchers have proposed the integration of energy harvesting technologies into sensor nodes to overcome that constraint and provide a sustainable WSN. This paper presents a formal approach to model and evaluate the Green Carrier Sense Multiple Access with Collision Avoidance (GCSMA/CA) MAC protocol in Energy Harvesting WSNs. This approach exploits the Hierarchical Timed Coloured Petri Nets (HTCPNs) formal method to design the GCSMA/CA protocol with the CPN-Tools for evaluating the proposed models. In addition, both qualitative and quantitative verification of the proposed models is tackled in this research. Linear Temporal Logic is used to formalise qualitative properties, and quantitative properties are evaluated by exploiting the monitor technique in CPN-Tools. The presented approach focuses on particular properties (performance delay, waiting time, waiting time for an acknowledgement, energy consumption and throughput) that have been overlooked in most prior studies. Time and hierarchy are two crucial features of the modelling process that HTCPNs offer. The time aspect allows time constraints for the GCSMA/CA protocol to be specified. On the other hand, the hierarchy aspect simplifies the modelling process and creates a modular and manageable model.