bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Thermodynamics and Dynamics in the Diurnal Cycle, Propagation, and Progression of Convective Storms in the Eastern Flank of the Indian Monsoon Trough
Authors: Jha Abhishek Kumar , Das Subrata Kumar , Krishna U. V. Murali , Deshpande Sachin M. 
Published: May 2022

Abstract
This study investigates the diurnal cycle, propagation, and progression of convective storms (CSs) on the eastern edge of India’s monsoon trough (MT) using 9 years of S-band radar measurements with satellite and reanalysis datasets. CSs initiate over ocean during midnight–early morning hours and propagate onshore in succeeding hours. CSs exhibit two semidiurnal peaks, one during afternoon hours over inland areas and another during midnight–early morning hours in oceanic/coastal locations. The deep and intense afternoon peak over inland regions is attributed to land surface heating and associated destabilization. The weak and shallower but organized midnight–morning peak and propagation of CSs toward the coast are attributed to the nocturnal land breeze and its interaction with prevailing onshore flow. The observed lead–lag of a few hours in the diurnal cycle of different cumulus modes correspond to the transition of congestus into deep and then, often, into overshooting modes. Moisture budget analysis showed atmospheric regulation of this transition through thermodynamic (congestus moistening) and dynamic processes (vertical advection). Theoretical time scales were invoked to estimate the relative role of vertical advective versus congestus moistening for promoting the afternoon transition from congestus to deeper modes. Comparing the time scales for congestus moistening (18–46 h) and dynamics (3 h) with the actual transition time scales (2–4 h) reveal that congestus moistening is too slow to explain the observed lead–lag in CS modes. Though both thermodynamic and dynamic processes moisten the midlevel prior to deep/overshooting convection, vertical advection is the dominant dynamic process for the observed congestus–deep–overshooting transition.

Significance Statement
Tropical rainfall is usually linked with convection in the morning and afternoon hours. We look at the basic physical processes that lead to those convective activities peaks. The afternoon peak is linked to maximum heating, resulting in an unstable environment, whereas the morning peak is linked to the interaction of large-scale monsoon flow with a land breeze. Furthermore, daily solar heating visually shows a shallow-to-deep progression of convection. The moist midlevel environment was shown to precede such convective development in a day. The large-scale monsoon flow is a dominant cause of this moistening. The monsoon dynamic flow takes roughly 2–3 h to sufficiently moist shallow storms into deep storms, whereas the local thermodynamic moistening process takes about 18–46 h.
A Satellite Climatology of Relative Humidity Profiles and Outgoing Thermal Radiation over Earth’s Oceans
Authors: Abraham Carsten , Goldblatt Colin 
Published: May 2022

Abstract
Satellite observations over Earth’s oceans show two distinct regimes in the relationship between sea surface temperatures (SST) and outgoing longwave radiation (OLR): a temperate regime (OLR increases with increasing SST quasi linearly) and the super greenhouse regime (OLR decrease with increasing SST). Transitions between these regimes occur via nonlinear atmospheric moistening, increasing relative humidity (RH). We perform a clustering analysis of about 450 million satellite-retrieved RH profiles and show that RH profiles over Earth’s oceans can be grouped into six and eight distinct and physically meaningful “primitive” classes for clear-sky and all-sky conditions, respectively. As the different RH-profile classes have distinct effects on OLR, can be associated with large-scale dynamical structures, and their occurrence is particular to different global ocean regions, the “primitive” clustering allows for studying large-scale radiative effects important for characterizing global climates and systematic relationships between SST, OLR, and atmospheric water vapor content. In both clear-sky and all-sky conditions three RH-profile classes correspond to the tropics. In the tropics, increasing SSTs are accompanied by systematic increases in both the occurrence probability and the observed RH magnitudes of the moistest RH-profile classes. Observations of moistest RH-profile classes are usually in a super greenhouse state (data in or likely to transition into the super greenhouse regime), and the formal characterization of them allows us to define an empirical threshold to identify which instantaneous observations are likely in a super greenhouse state. Applying this threshold we are able to identify typical regions in the super greenhouse regime.
On the Influence of Surface Latent Heat Fluxes on Idealized Extratropical Cyclones
Authors: Demirdjian Reuben , Doyle James D. , Finocchio Peter M. , Reynolds Carolyn A. 
Published: May 2022

Abstract
An analysis of the surface latent heat flux (SLHF) influence on the accumulated precipitation associated with an idealized extratropical cyclone using the Coupled Ocean–Atmosphere Mesoscale Prediction System is presented. There are two distinct precipitation regions found to be strongly influenced by the SLHF, referred to as the primary maximum and the cold-frontal precipitation. A substantial reduction by approximately 30 mm (35%) and 15 mm (75%) is observed in the accumulated precipitation of the two regions, respectively, when the SLHF is eliminated domain wide at 96 h—the starting time of the most rapid cyclone deepening. The source of this reduction is investigated by systematically controlling the SLHF in three cyclone sectors, which are the low-latitude, baroclinic, and high-latitude sectors. The precipitation in the primary maximum is most strongly controlled by the baroclinic sector, which experiences strong upward SLHF due to its dry environmental air. In contrast, the precipitation in the cold-frontal zone is most strongly controlled by the low-latitude sector, which experiences only a moderate amount of upward SLHF into the already warm and moist boundary layer air. The results underscore the crucial role of SLHF and boundary layer processes in precipitation predictions and demonstrate the need for accurate forecasts of air–sea temperature contrast, surface level winds, and moisture to properly simulate air–sea interactions.
GPM Ground Validation at NASA Wallops Precipitation Research Facility
Authors: Pabla Charanjit S. , Wolff David B. , Marks David A. , Wingo Stephanie M. , Pippitt Jason L. 
Published: May 2022

Abstract
The Wallops Precipitation Research Facility (WPRF) at NASA Goddard Space Flight Center, Wallops Island, Virginia, has been established as a semipermanent supersite for the Global Precipitation Measurement (GPM) Ground Validation (GV) program. WPRF is home to research-quality precipitation instruments, including NASA’s S-band dual-polarimetric radar (NPOL), and a network of profiling radars, disdrometers, and rain gauges. This study investigates the statistical agreement of the GPM Core Observatory Dual-Frequency Precipitation Radar (DPR), combined DPR–GPM Microwave Imager (GMI) and GMI level II precipitation retrievals compared to WPRF ground observations from a 6-yr collection of satellite overpasses. Multisensor observations are integrated using the System for Integrating Multiplatform Data to Build the Atmospheric Column (SIMBA) software package. SIMBA ensures measurements recorded in a variety of formats are synthesized into a common reference frame for ease in comparison and analysis. Given that instantaneous satellite measurements are observed above ground level, this study investigates the possibility of a time lag between satellite and surface mass-weighted mean diameter (Dm), reflectivity (Z), and precipitation rate (R) observations. Results indicate that time lags vary up to 30 min after overpass time but are not consistent between cases. In addition, GPM Core Observatory Dm retrievals are within level I mission science requirements as compared to WPRF ground observations. Results also indicate GPM algorithms overestimate light rain (<1.0 mm h−1). Two very different stratiform rain vertical profiles show differing results when compared to ground reference data. A key finding of this study indicates multisensor DPR/GMI combined algorithms outperform single-sensor DPR algorithm.

Significance Statement
Satellites are beneficial for global precipitation surveillance because extensive ground instruments are lacking, especially over oceans. Ground validation studies are required to calibrate and improve precipitation algorithms from satellite sensors. The primary goal of this study is to quantify the differences between satellite raindrop size and rain-rate retrieval with ground-based observations. Rainfall-rate algorithms require assumptions about the mean raindrop size. Results indicate Global Precipitation Measurement (GPM)/satellite-based mean raindrop size is within acceptable error (±0.5 mm) with respect to ground measurements. In addition, GPM satellite measurements overestimate light rain (<1.0 mm h−1), which is important during the winter months and at high latitudes. Illuminating the challenges of GPM satellite-based precipitation estimation can guide algorithm developers to improve retrievals.
Safety and efficacy of a dose-dense short-term therapy in patients with MYC-translocated aggressive lymphoma
Authors: Ferreri Andrés J. M. , Angelillo Piera , Erbella Federico , Cattaneo Chiara , Verga Luisa , Lleshi Arben , Allione Bernardino , Ponzoni Maurilio , Facchetti Fabio , Pagani Chiara , Foppoli Marco , Pecciarini Lorenza , Sassone Marianna , Steffanoni Sara , Flospergher Elena , Rossi Giuseppe , Spina Michele , Re Alessandro 
Published: May 2022

Abstract
Patients with aggressive B-cell lymphoma and MYC rearrangement at fluorescence in situ hybridization exhibit poor outcome after R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). In the last decade, 68 patients with Burkitt lymphoma ([BL] n = 46) or high-grade B-cell lymphoma ([HGBCL] single, double, or triple hit; n = 22) were treated with a dose-dense, short-term therapy termed “CARMEN regimen” at 5 Italian centers. Forty-six (68%) patients were HIV+. CARMEN included a 36-day induction with sequential, single weekly doses of cyclophosphamide, vincristine, rituximab, methotrexate, etoposide, and doxorubicin plus intrathecal chemotherapy, followed by high-dose-cytarabine–based consolidation. Patients who did not achieve complete remission (CR) after induction received BEAM (carmustina, etoposide, cytarabine, melfalan)-conditioned autologous stem cell transplantation (ASCT) after consolidation. Sixty-one (90%) patients completed induction, and 59 (87%) completed consolidation. Seventeen patients received ASCT. Grade 4 hematological toxicity was common but did not cause treatment discontinuation; grade 4 nonhematological toxicity was recorded in 11 (16%) patients, with grade 4 infections in 6 (9%). Six (9%) patients died of toxicity (sepsis in 4, COVID-19, acute respiratory distress syndrome). CR rate after the whole treatment was 73% (95% confidence interval [CI], 55% to 91%) for patients with HGBCL and 78% (95% CI, 66% to 90%) for patients with BL. At a median follow-up of 65 (interquartile range, 40-109) months, 48 patients remain event free, with a 5-year progression-free survival of 63% (95% CI, 58% to 68%) for HGBCL and 72% (95% CI, 71% to 73%) for BL, with a 5-year overall survival (OS) of 63% (95% CI, 58% to 68%) and 76% (95% CI, 75% to 77%), respectively. HIV seropositivity did not have a detrimental effect on outcome. This retrospective study shows that CARMEN is a safe and active regimen both in HIV-negative and -positive patients with MYC-rearranged lymphomas. Encouraging survival figures, attained with a single dose of doxorubicin and cyclophosphamide, deserve further investigation in HGBCL and other aggressive lymphomas.
Factors contributing to the mental health outcomes of carers during the transition of their family member to residential aged care: a systematic search and narrative review
Authors: Camões-Costa Vera , Loganathan Jayasree , Barton Chris , Chakraborty Samantha , Hewitt Alana , Lin Xiaoping , Brijnath Bianca 
Published: May 2022

Abstract
Objectives
The transition of an older family member into a residential aged care facility (RACF) is often challenging for both the person being admitted and their family carer. This review aimed to identify the protective and contributing factors to adverse mental health outcomes among family carers following the decision to move a family member to a RACF.

Method
A search of CINAHL, PubMed and PsycINFO was conducted for empirical papers published in English between 2004 and 2019, exploring the mental health or quality of life (QoL) of family carers of those recently admitted, or considering admission, to a RACF. Articles were reviewed by two authors for inclusion.

Results
Twenty-three studies met the inclusion criteria. Pre-existing depressive symptoms and poor subjective health were related to adverse mental health outcomes following admission. Information from the facility, support to change roles, and factors related to carer’s health and demographics, were associated with changes in the mental health outcomes of carers during the transition of their relative to a RACF. Key protective factors of carer’s mental health outcomes following the transition of their relative to a RACF are flow and transparency of information between carer and the facility staff, and staff efforts to involve carers in providing emotional support to their relative, in monitoring care, and advocating for their quality of life.

Conclusion
There is evidence to suggest factors such lack of flow and transparency of information between carer and the facility staff may predispose carers to poor mental health and QoL following the transition of a relative to a RACF. Key protective factors of carer’s mental health following admission are staff efforts to involve carers in providing emotional support to their relative, in monitoring care, and advocating for their quality of life. This review also indicates that the combination of factors that puts family carers more at risk of poor mental health and lower quality of life throughout the transition period. Policy and practice should follow recommendations that consider a combination of the above factors when addressing the needs of family carers before and after admission of an older person to RACF.
Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs
Authors: Nowlan Bianca , Williams Elizabeth D. , Doran Michael Robert 
Published: May 2022

Abstract
Background
While prostate cancer (PCa) cells most often metastasize to bone in men, species-specific differences between human and mouse bone marrow mean that this pattern is not faithfully replicated in mice. Herein we evaluated the impact of partially humanizing mouse bone marrow with human bone marrow-derived stromal cells (BMSC, also known as "mesenchymal stem cells") on human PCa cell behaviour.

Methods
BMSC are key cellular constituents of marrow. We used intrafemoral injection to transplant 5 × 105 luciferase (Luc) and green fluorescence protein (GFP) expressing human BMSC (hBMSC-Luc/GFP) into the right femur of non-obese diabetic (NOD)-severe combined immunodeficiency (scid) interleukin (IL)-2γ−/− (NSG) mice. Two weeks later, 2.5 × 106 PC-3 prostate cancer cells expressing DsRed (PC-3-DsRed) were delivered into the mice via intracardiac injection. PC-3-DsRed cells were tracked over time using an In Vivo Imaging System (IVIS) live animal imaging system, X-ray and IVIS imaging performed on harvested organs, and PC-3 cell numbers in femurs quantified using flow cytometry and histology.

Results
Flow cytometry analysis revealed greater PC-3-DsRed cell numbers within femurs of the mice that received hBMSC-Luc/GFP. However, while there were overall greater PC-3-DsRed cell numbers in these animals, there were not more PC-3-DsRed in the femurs injected with hBMSC-Luc/GFP than in contralateral femurs. A similar proportion of mice in with or without hBMSC-Luc/GFP had bone lessions, but the absolute number of bone lesions was greater in mice that had received hBMSC-Luc/GFP.

Conclusion
PC-3-DsRed cells preferentially populated bones in mice that had received hBMSC-Luc/GFP, although PC-3-DsRed cells not specifically localize in the bone marrow cavity where hBMSC-Luc/GFP had been transplanted. hBMSC-Luc/GFP appear to modify mouse biology in a manner that supports PC-3-DsRed tumor development, rather than specifically influencing PC-3-DsRed cell homing. This study provides useful insights into the role of humanizing murine bone marrow with hBMSC to study human PCa cell biology.
Fulminant anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluR1 antibodies encephalitis in a Chinese boy: a case report
Authors: Han Wei , Ma Jiannan , Jiang Li , Cheng Min 
Published: May 2022

Abstract
Background
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis is a rare autoimmune synaptic encephalitis associated with autoantibodies that cause a selective decrease in surface expression and changes in receptor localization. Anti-AMPAR encephalitis is poorly recognized, especially in children, and its clinical phenotype is incompletely described.

Case presentation
We report a case of anti-AMPAR GluR1 antibody-mediated autoimmune encephalitis in a 12-year-old male. The patient manifested as a fulminant course, with ataxia, cerebellar degeneration at the onset, and rapidly evolved into hyperthermia, coma and rhabdomyolysis. Antibodies against AMPAR GluR1 receptors were detected in the cerebrospinal fluid by cell-based assay. Diffuse slow waves were found by electroencephalograph, and the left cerebellar vermis and hemisphere were affected on brain magnetic resonance imaging (MRI). The patient was treated with intravenous immunoglobulin (IVIG), methylprednisolone combined with plasma exchange. Symptoms were alleviated after immunotherapy and the patient sustained clinical improvement. This is the first time that acute rhabdomyolysis symptom has been identified in a pediatric patient with anti-AMPAR encephalitis.

Conclusions
This case expands the clinical spectrum of anti-AMPAR encephalitis and highlights that despite poor clinical manifestation at the outset, recovery remains possible.
Prevalence and predictors of water-borne diseases among elderly people in India: evidence from Longitudinal Ageing Study in India, 2017–18
Authors: Kumar Pradeep , Srivastava Shobhit , Banerjee Adrita , Banerjee Snigdha 
Published: May 2022

Abstract
Background
India suffers from a high burden of diarrhoea and other water-borne diseases due to unsafe water, inadequate sanitation and poor hygiene practices among human population. With age the immune system becomes complex and antibody alone does not determine susceptibility to diseases which increases the chances of waterborne disease among elderly population. Therefore the study examines the prevalence and predictors of water-borne diseases among elderly in India.

Method
Data for this study was collected from the Longitudinal Ageing Study in India (LASI), 2017–18. Descriptive statistics along with bivariate analysis was used in the present study to reveal the initial results. Proportion test was applied to check the significance level of prevalence of water borne diseases between urban and rural place of residence. Additionally, binary logistic regression analysis was used to estimate the association between the outcome variable (water borne diseases) and the explanatory variables.

Results
The study finds the prevalence of water borne disease among the elderly is more in the rural (22.5%) areas compared to the urban counterparts (12.2%) due to the use of unimproved water sources. The percentage of population aged 60 years and above with waterborne disease is more in the central Indian states like Chhattisgarh and Madhya Pradesh followed by the North Indian states. Sex of the participate, educational status, work status, BMI, place of residence, type of toilet facility and water source are important determinants of water borne disease among elderly in India.

Conclusion
Elderly people living in the rural areas are more prone to waterborne diseases. The study also finds state wise variation in prevalence of waterborne diseases. The elderly people might not be aware of the hygiene practices which further adhere to the disease risk. Therefore, there is a need to create awareness on basic hygiene among this population for preventing such bacterial diseases.
Social media use and mental health during the COVID-19 pandemic in young adults: a meta-analysis of 14 cross-sectional studies
Authors: Lee Youngrong , Jeon Ye Jin , Kang Sunghyuk , Shin Jae Il , Jung Young-Chul , Jung Sun Jae 
Published: May 2022

Abstract
Background
Public isolated due to the early quarantine regarding coronavirus disease 2019 (COVID-19) increasingly used more social media platforms. Contradictory claims regarding the effect of social media use on mental health needs to be resolved. The purpose of the study was to summarise the association between the time spent on social media platform during the COVID-19 quarantine and mental health outcomes (i.e., anxiety and depression).

Methods
Studies were screened from the PubMed, Embase, and Cochrane Library databases. Regarding eligibility criteria, studies conducted after the declaration of the pandemic, studies that measured mental health symptoms with validated tools, and studies that presented quantitative results were eligible. The studies after retrieval evaluated the association between time spent on social media platform and mental health outcomes (i.e. anxiety and depression). The pooled estimates of retrieved studies were summarised in odds ratios (ORs). Data analyses included a random-effect model and an assessment of inter-study heterogeneity. Quality assessment was conducted by two independent researchers using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS). This meta-analysis review was registered in PROSPERO (https://www.crd.york.ac.uk/PROSPERO/, registration No CRD42021260223, 15 June 2021).

Results
Fourteen studies were included. The increase in the time spent using social media platforms were associated with anxiety symptoms in overall studies (pooled OR = 1.55, 95% CI: 1.30–1.85), and the heterogeneity between studies was mild (I2 = 26.77%). Similarly, the increase in social media use time was also associated with depressive symptoms (pooled OR = 1.43, 95% CI: 1.30–1.85), and the heterogeneity between studies was moderate (I2 = 67.16%). For sensitivity analysis, the results of analysis including only the “High quality” studies after quality assessment were similar to those of the overall study with low heterogeneity (anxiety: pooled OR = 1.45, 95% CI: 1.21–1.96, I2 = 0.00%; depression: pooled OR = 1.42, 95% CI: 0.69–2.90, I2 = 0.00%).

Conclusions
The analysis demonstrated that the excessive time spent on social media platform was associated with a greater likelihood of having symptoms of anxiety and depression.