bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Phenotypes of Anxiety and Depression: Analysis of Combined Comorbidity and Treatment in Patients Undergoing Spinal Fusion
Authors: Jain Nikhil , Sharma Mayur , Wang Dengzhi , Ugiliweneza Beatrice , Drazin Doniel , Boakye Maxwell 
Published: April 2022

BACKGROUND:
Anxiety and depression are associated with suboptimal outcomes, higher complications, and cost of care after elective spine surgery. The effect of combined anxiety-depression and preoperative antidepressant treatment in spinal fusion patients is not known.

OBJECTIVE:
To study the burden of combined anxiety-depression and its impact on healthcare utilization and costs in patients undergoing spinal fusion and to study the prevalence and impact of antidepressant treatment preoperatively.

METHODS:
This is a retrospective cohort study from the IBM MarketScan Research Database (2000-2018). Patients were studied in 7 different “phenotypes” of anxiety and depression based on combination of diagnoses and treatment. Outcome measures included healthcare utilization and costs from 1 year preoperatively to 2 years postoperatively. Bivariate and multivariable analyses have been reported.

RESULTS:
We studied 75 087 patients with a median age of 57 years. Patients with combined anxiety-depression were associated with higher preoperative and postoperative healthcare utilization and costs, as compared with anxiety or depression alone. The presence of depression in patients with and without anxiety disorder was a risk factor for postoperative opioid use and 2-year reoperation rates, as compared with anxiety alone. Patients with anxiety and/or depression on antidepressants are associated with significantly higher healthcare costs and opioid use. The adjusted 2-year reoperation rate was not significantly different between treated and untreated cohorts.

CONCLUSION:
Spine surgeons should use appropriate measures/questionnaires to screen depressed patients for anxiety and vice versa because the presence of both adds significant risk of higher healthcare utilization and costs over patients with 1 diagnosis, especially anxiety alone.
Offline Pricing and Demand Learning with Censored Data
Authors: Bu Jinzhi , Simchi-Levi David , Wang Li 
Published: April 2022

We study a single product pricing problem with demand censoring in an offline data-driven setting. In this problem, a retailer has a finite amount of inventory and faces a random demand that is price sensitive in a linear fashion with unknown price sensitivity and base demand distribution. Any unsatisfied demand that exceeds the inventory level is lost and unobservable. We assume that the retailer has access to an offline data set consisting of triples of historical price, inventory level, and potentially censored sales quantity. The retailer’s objective is to use the offline data set to find an optimal price, maximizing his or her expected revenue with finite inventories. Because of demand censoring in the offline data, we show that the existence of near-optimal algorithms in a data-driven problem—which we call problem identifiability—is not always guaranteed. We develop a necessary and sufficient condition for problem identifiability by comparing the solutions to two distributionally robust optimization problems. We propose a novel data-driven algorithm that hedges against the distributional uncertainty arising from censored data, with provable finite-sample performance guarantees regardless of problem identifiability and offline data quality. Specifically, we prove that, for identifiable problems, the proposed algorithm is near-optimal and, for unidentifiable problems, its worst-case revenue loss approaches the best-achievable minimax revenue loss that any data-driven algorithm must incur. Numerical experiments demonstrate that our proposed algorithm is highly effective and significantly improves both the expected and worst-case revenues compared with three regression-based algorithms. This paper was accepted by J. George Shanthikumar, big data analytics. Funding: This work was supported by the MIT Data Science Laboratory. J. Bu was partially supported by a Hong Kong Polytechnic University Start-up Fund for New Recruits [Project ID P0039585]. Supplemental Material: Data and the online appendices are available at https://doi.org/10.1287/mnsc.2022.4382 .
N,N-Dimethylformamide inhibits high glucose-induced osteoporosis via attenuating MAPK and NF-κB signalling
Authors: Liu Ya Dong , Liu Jian Feng , Liu Bin 
Published: April 2022

Aims The role of N,N-dimethylformamide (DMF) in diabetes-induced osteoporosis (DM-OS) progression remains unclear. Here, we aimed to explore the effect of DMF on DM-OS development. Methods Diabetic models of mice, RAW 264.7 cells, and bone marrow macrophages (BMMs) were established by streptozotocin stimulation, high glucose treatment, and receptor activator of nuclear factor-κB ligand (RANKL) treatment, respectively. The effects of DMF on DM-OS development in these models were examined by micro-CT analysis, haematoxylin and eosin (H&E) staining, osteoclast differentiation of RAW 264.7 cells and BMMs, H&E and tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assay (ELISA) of TRAP5b and c-terminal telopeptides of type 1 (CTX1) analyses, reactive oxygen species (ROS) analysis, quantitative reverse transcription polymerase chain reaction (qRT-PCR), Cell Counting Kit-8 (CCK-8) assay, and Western blot. Results The established diabetic mice were more sensitive to ovariectomy (OVX)-induced osteoporosis, and DMF treatment inhibited the sensitivity. OVX-treated diabetic mice exhibited higher TRAP5b and c-terminal telopeptides of type 1 (CTX1) levels, and DMF treatment inhibited the enhancement. DMF reduced RAW 264.7 cell viability. Glucose treatment enhanced the levels of TRAP5b, cathepsin K, Atp6v0d2, and H+-ATPase, ROS, while DMF reversed this phenotype. The glucose-increased protein levels were inhibited by DMF in cells treated with RANKL. The expression levels of antioxidant enzymes Gclc, Gclm, Ho-1, and Nqo1 were upregulated by DMF. DMF attenuated high glucose-caused osteoclast differentiation by targeting mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signalling in BMMs. Conclusion DMF inhibits high glucose-induced osteoporosis by targeting MAPK and NF-κB signalling. Cite this article: Bone Joint Res 2022;11(4):200–209.
The feasibility of achieving Elective Care Framework targets for total hip arthroplasty and total knee arthroplasty in Northern Ireland
Authors: Mayne Alistair I. W. , Cassidy Roslyn S. , Magill Paul , Mockford B. J. , Acton Danny A. , McAlinden M. Gavan 
Published: April 2022

Aims Waiting times for arthroplasty surgery in Northern Ireland are among the longest in the NHS, which have been further lengthened by the onset of the COVID-19 global pandemic in March 2020. The Department of Health in Northern Ireland has announced a new Elective Care Framework (ECF), with the framework proposing that by March 2026 no patient will wait more than 52 weeks for inpatient/day case treatment. We aimed to assess the feasibility of achieving this with reference to total hip arthroplasty (THA) and total knee arthroplasty (TKA). Methods Mathematical modelling was undertaken to calculate when the ECF targets will be achieved for THA and TKA, as well as the time when waiting lists for THA and TKA will be cleared. The number of patients currently on the waiting list and percentage operating capacity relative to pre-COVID-19 capacity was used to determine future projections. Results As of May 2021, there were 3,757 patients awaiting primary THA and 4,469 patients awaiting primary TKA in Northern Ireland. Prior to April 2020, there were a mean 2,346 (2,085 to 2,610) patients per annum boarded for primary THA, a mean 2,514 (2,494 to 2,514) patients per annum boarded for primary TKA, and there were a mean 1,554 primary THAs and 1,518 primary TKAs performed per annum. The ECF targets for THA will only be achieved in 2030 if operating capacity is 200% of pre COVID-19 pandemic capacity and in 2042 if capacity is 170%. For TKA, the targets will be met in 2034 if capacity is 200% of pre-COVID-19 pandemic capacity. Conclusion This modelling demonstrates that, in the absence of major funding and reorganization of elective orthopaedic care, the targets set out in the ECF will not be achieved with regard to THA and TKA. Waiting times for THA and TKA surgery in Northern Ireland are likely to remain greater than 52 weeks for most of this decade. Cite this article: Bone Jt Open 2022;3(4):302–306.
Enhanced lighting on the road surface with TIR-PA optical element on tunnel sidewall
Authors: Guo Ziyang , Dai Haitao , Gao Meini , Zhang Yu , Hao Xichen , Zhang Han , Mohamed Zolkefl A. Y. , Fu Yikai , Feng Shouzhong 
Published: April 2022

Both the lighting quality and driving safety inside the tunnel have been quite a concern around the world. In this study, a plate with prism array of total internal reflection (TIR-PA) has been designed to enhance the lighting on the road surface inside the tunnel in adherence to traffic safety as well as energy savings. Such optical elements, above the tunnel sidewall, can redirect the rays emitted from both the headlight and lighting devices to the road surface, which supports higher flux on the road. Simultaneously, the simulation is conducted with consideration of practical factors based on the mathematical model and edge-ray principle to attain the effect of the TIR-PA plates. On the one hand, for the rays from the lighting devices, the enhancement rate of illuminance has reached 12.60%–16.58%, which is attributed to TIR-PA plates above the different sidewalls of the Lambertian scattering property. TIR-PA can be suitable for various sidewall materials due to the small effect of illumination reduction. On the other hand, 30.2%–32.2% rays of the headlight source received by the sidewall, due to the effect of TIR-PA plates, are redirected to the driving distance for 27.3–71.9 m, which makes

15.9
−
31.1

m

2

of road surface brighter. It makes contributions to the improvement of illuminance distribution and drivers’ pre-judgment. In the future, broader applications regarding the TIR-PA plates will be explored widely in tunnel lighting systems due to the low production cost.
Quantum phase modulation with acoustic cavities and quantum dots
Authors: Imany Poolad , Wang Zixuan , DeCrescent Ryan A. , Boutelle Robert C. , McDonald Corey A. , Autry Travis , Berweger Samuel , Kabos Pavel , Nam Sae Woo , Mirin Richard P. , Silverman Kevin L. 
Published: April 2022

Fast, efficient, and low-power modulation of light at microwave
frequencies is crucial for chip-scale classical and quantum processing
as well as for long-range networks of superconducting quantum
processors. A successful approach to bridge the gap between microwave
and optical photons has been to use intermediate platforms, such as
acoustic waves, that couple efficiently to a variety of quantum
systems. Here, we use gigahertz-frequency focusing surface acoustic
wave cavities on GaAs that are piezo-electrically coupled to
superconducting circuits and parametrically coupled, via strain, to
photons scattered from InAs quantum dots. We demonstrate modulation of
single photons with a half-wave voltage as low as 44 mV, and
subnatural modulation sideband linewidths. These demonstrations pave
the way for efficient and low-noise transduction of quantum
information between microwave and optical domains.
Terahertz electrometry via infrared spectroscopy of atomic vapor
Authors: Chen Shuying , Reed Dominic J. , MacKellar Andrew R. , Downes Lucy A. , Almuhawish Nourah F. A. , Jamieson Matthew J. , Adams Charles S. , Weatherill Kevin J. 
Published: April 2022

In recent years, the characterization of radiation falling within the so-called “terahertz (THz) gap” has become an ever more prominent issue due to the increasing use of THz systems in applications such as nondestructive testing, security screening, telecommunications, and medical diagnostics. THz detection technologies have advanced rapidly, yet traceable calibration of THz radiation remains challenging. In this paper, we demonstrate a system of electrometry in which a THz signal can be characterized using laser spectroscopy of highly excited (Rydberg) atomic states. We report on proof-of-principle measurements that reveal a minimum detectable THz electric field amplitude of

1.07
±
0.06

V

/

m

at 1.06 THz (3 ms detection), corresponding to a THz power at the atomic cell of approximately 3.4 nW. Due to the relative simplicity and cryogen-free nature of this system, it has the potential to provide a route to a SI traceable “atomic candle” for THz calibration across the THz frequency range, and provide an alternative to calorimetric methods.
Assessment of environmental contamination with soil-transmitted helminths life stages at school compounds, households and open markets in Jimma Town, Ethiopia
Authors: Tadege Bamlaku , Mekonnen Zeleke , Dana Daniel , Sharew Bizuwarek , Dereje Eden , Loha Eskindir , Verweij Jaco J. , Casaert Stijn , Vlaminck Johnny , Ayana Mio , Levecke Bruno 
Published: April 2022

Background
It remains largely unknown where and how infections with soil-transmitted helminths (STHs; Ascaris, Trichuris, Necator and Ancylostoma) occur. We therefore aimed to identify possible sources of infection by assessing the environmental contamination in an STH-endemic area.

Methods
We first performed a series of laboratory experiments designed to optimize a soil straining-flotation method to detect and quantify Ascaris and Trichuris eggs in soil, and to validate the diagnostic performance of the optimized method when followed by microscopy and qPCR. In a second phase, we applied this method to assess the level of STH contamination in 399 environmental samples collected from 10 school compounds, 50 households and 9 open markets in Jimma Town (Ethiopia). Subsequently, we explored associations between the environmental contamination and both the corresponding STH epidemiology at the level of the schools and the household characteristics. Finally, we assessed the knowledge, attitude and practice (KAP) towards STHs in school children.

Principal findings
Our soil straining-flotation method has an analytical sensitivity of 50 eggs per 100 grams of soil and egg recovery rate of 36.0% (Ascaris) and 8.0% (Trichuris). The analysis of field samples with both microscopy and qPCR revealed the presence of 8 different helminth species of medical importance, including but not limited to the human STHs. There was a significant association between the environmental contamination and prevalence of any STH infections at the school level only. The KAP indicated a lack of knowledge and awareness of STHs.

Conclusions/Significance
Our optimized straining-flotation method has a moderate diagnostic performance and revealed that life stages of helminths are ubiquitous in the environment, which might be due to the poor sanitary facilities at both the schools and the households, and a poor level of KAP towards STHs. Further research is required to gain more insights into the contribution of these life stages to transmission.
Mandibular full-arch fixed prostheses supported by three-dental-implants: A protocol of an overview of reviews
Authors: Afrashtehfar Kelvin I. , Moawad Rosalin A. , F.-Eddin Afaf W. , Wang Hom-Lay 
Published: April 2022

IntroductionTo minimize trauma and cost of treatment, oral health practitioners have successfully rehabilitated full arches by supporting the prostheses on four implants. However, there is no consensus whether less than four implants supporting full mandibular arches would provide similar clinical outcomes to other well-established all-on-four alternative.ObjectiveTo identify, summarize, appraise, and compare the clinical outcomes evidence of three-implant fixed full-arch prostheses in completely edentulous mandibular patients.Materials and methodsThis overview of systematic reviews (OoSRs) will include secondary synthesis studies (i.e., systematic reviews with or without a meta-analysis). A three-step search strategy will be conducted in MEDLINE (Ovid), EMBASE (Ovid), Cochrane Database of Systematic Reviews, Scopus, Web of Science (WoS Core Collection), and Google Scholar. Grey literature and a manual search in 12 specialized journals will also be conducted. Three independent reviewers will screen all retrieved articles for eligibility, extract data and assess the methodological quality of the included studies. The results will be presented as tables or narrative synthesis. The studies will be evaluated for risk of bias by ROBIS and methodology quality by the AMSTAR-2 tool. If new primary studies are identified, a meta-analysis will be conducted. Certainty of the evidence will be assessed to answer the following focused research question: In edentulous mandibular patients, what are the implant and prostheses clinical outcomes of three-implant fixed full-arch prostheses compared to other all-on-x solutions?DiscussionThere are some systematic reviews about the use of fixed complete dental prostheses supported by three implants; however, their clinical outcomes related to the other all-on-four plus solutions are conflicting. So, an overview on this topic is required to provide recommendations.Review registration numberInternational prospective register of systematic reviews (PROSPERO) ID#:CRD42021262175. National Institute for Health Research (NIHR) and Centre for Reviews and Dissemination, University of York, York, United Kingdom.
Perceived risks of COVID-19, attitudes towards preventive guidelines and impact of the lockdown on students in Uganda: A cross-sectional study
Authors: Niba Rawlings Ngwa , Akwah Emmanuela Ambe , Musisi James , Awanchiri Kimonia , Babirye Rachel , Emalieu Diana , Nduhukyire Lawrence , Kakeeto Ronald , Ngongalah Lem 
Published: April 2022

Background
This study explored students’ perceptions of COVID-19 risks and preventive measures and assessed the impacts of the national lockdown on students in Uganda.

Methods
A web-based survey was conducted to explore students’ perceived risks of COVID-19 and preventive measures; sources of COVID-19 information and impacts of the lockdown. Both undergraduate and post-graduate students (n = 398) participated in the study. Data were analysed using IBM-SPSS-26.

Results
Students acknowledged COVID-19 as a health risk, and their preventive behaviours were influenced by age, gender, marital status and living situation. Most students followed face mask guidelines but did not comply with lockdown restrictions. Social distancing was not always possible due to overcrowding. Students’ main sources of COVID-19 information were local media (e.g., TV, radio) and social media. Most students (especially females) were unable to access online learning platforms due to poor internet connectivity, high costs and no access to computers. Meanwhile, a majority of those who studied online did not enjoy the experience. Students experienced depression, frustration, stress and anxiety during the lockdown; became less physically active and spent most of their time on social media, sleeping, eating or watching movies. Some students indulged in smoking, drinking alcohol, taking drugs and gambling for their first time, while others did them more often than before.

Conclusion
The increase in sedentary activity, poor mental health and substance use over the lockdown period puts students at risk of health complications and poses a potential threat to the healthcare system. These risks may also negatively impact their future learning and academic potential. Further research is needed to understand the transitional experiences of students between physical and virtual learning, and how they can be supported. There is also a need to ascertain the feasibility of guidelines such as social distancing in developing countries, to increase compliance.
Mental health disorders among post graduate residents in Kenya during the COVID-19 pandemic
Authors: Ali Sayed K. , Shah Jasmit , Du Katie , Leekha Nidhi , Talib Zohray 
Published: April 2022

BackgroundHealthcare workers, including residents, are prone to various mental health disorders especially given the context of the COVID-19 pandemic. Residents, particularly, are already under undue stress due to their respective training program demands.MethodsThis cross-sectional, online survey-based study from August to November 2020 collected demographic and mental health measurements from all residents at the Aga Khan University Hospital, Nairobi. The questionnaire investigated demographic variables, information regarding direct care of COVID-19 patients, prior history of mental health and mental health outcomes using the Patient Health Questionnaire, Generalized Anxiety Disorder scale, Insomnia Severity Index, Impact of Event Scale–Revised Questionnaire and Stanford Professional Fulfillment Index Questionnaire.ResultsA total of 100 residents completed the survey (participation rate 77.5%). Participants were about equal in gender (women [53%]), with a median age of 31.28 years, and majority were single (66.7%). A total of 66 participants (66%) were directly engaged in COVID-19 care. Depression: 64.3%, anxiety: 51.5%, insomnia: 40.5%, distress: 35.4%, and burnout: 51.0% were reported in all participants. Statistical significance was found in median depression, professional fulfillment and interpersonal disengagement when comparing frontline resident directly involved in care of COVID-19 patient versus second line residents.ConclusionResidents directly involved with caring for COVID-19 patients had statistically higher incidences of depression and interpersonal disengagement and lower professional fulfillment compared to second line residents. Keeping in mind the limited resources in sub-Saharan Africa, urgent and geographically specific strategies are needed to help combat mental health disorders in this specific population.
Endoscopia bajo sueño inducido en la apnea obstructiva del sueño (DISE). Estudio comparativo entre las clasificaciones NOHLy VOTE
Authors: Pérez-Martín Nuria , Bosco-Morales Gabriela , Morato-Galán Marta , Hernández-García Estefania , O´Connor-Reina Carlos , Plaza-Mayor Guillermo 
Published: April 2022

Introducción y objetivo: Varias clasificaciones han sido propuestas para expresar los resultados de la endoscopia bajo sueño inducido (DISE) en la apnea obstructiva del sueño (AOS), pero ninguna está globalmente aceptada. El objetivo del estudio es analizar las clasificaciones más utilizadas: NOHL y VOTE, para valorar cuál de ellas aporta más ventajas.
Método: Se diseñó un estudio de cohortes prospectivo de 100 pacientes a los que se les realizó una DISE por AOS. Tres otorrinolaringólogos evaluaron de forma ciega los videos de las DISE y codificaron los resultados de acuerdo a las escalas NOHL y VOTE, anotando qué hallazgos determinaban la indicación de cirugía.
Resultados: Según el investigador principal, en un 64% se indicó cirugía de un solo nivel, de estos, el paladar fue el más predominante, en el 26% se indicó cirugía multinivel y en un 10% se desestimó cirugía. La concordancia global para expresar los resultados de la DISE según las escalas NOHL y VOTE, en cuanto al grado de obstrucción es moderada / regular a nivel de la epiglotis (k = 0,467) y baja en el resto de estructuras (k = 0,097).
Discusión: A pesar de que el grado de acuerdo interobservador es similar en ambas escalas, para VOTE es ligeramente superior.
Conclusiones: La DISE es una prueba segura, reproducible y fácil de realizar. Recomendamos el uso de la escala VOTE porque ha demostrado tener un grado de acuerdo interobservador superior, es la escala más utilizada en la literatura y la recomendada en los documentos de consenso.