bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sourcemap: a graphical representation to enhance the low frequency source radiation
Authors: Herrero A , Avallone A 
Published: April 2022

SUMMARY
Data from dense seismic arrays allow nowadays to map directly the radiation of the seismic source in space. However, the main features observed on these maps are usually linked to the propagation, its attenuation and some site effects. Only few parameters like the magnitude or fault extension may be inferred through the shape and the size of the epicentral area. In this work, we propose a new strategy able to produce fast qualitative maps, ‘Sourcemaps’, that highlight directly some basic characteristics of the seismic source. They are based on a parameter which is robust and fast to compute with a minimal processing: the displacement response spectrum (DRS) computed at low frequency. In order to highlight the source effects, we correct the DRS by the geometrical spreading. We have applied this strategy to some earthquakes occurred in Japan in the last 25 yr using K-NET/KiK-net data. In these examples, we show that the source parameters such as the focal mechanism (nodal planes) and the directivity may be clearly seen on the Sourcemaps. Some site effects at large scale are still visible. The strategy proposed in this work is completely automatic without the need of a visual inspection of the input data. Thus it provides a robust assessment of key parameters of the source. We suggest a systematic computation of these ‘Sourcemaps’ after each event inside a dense network.
Severe Activity of Inflammatory Bowel Disease is a Risk Factor for Severe COVID-19
Authors: Macaluso Fabio Salvatore , Giuliano Alessandra , Fries, Walter , Viola Anna , Abbruzzese Alfredo , Cappello Maria , Giuffrida Enrica , Carrozza Lucio , Privitera Antonino Carlo , Magnano Antonio , Ferracane Concetta , Scalisi Giuseppe , Minissale Maria Giovanna , Giangreco Emiliano , Garufi Serena , Bertolami Carmelo , Cucinotta Ugo , Graziano Francesco , Casà Angelo , Renna Sara , Teresi Giulia , Rizzuto Giulia , Mannino Mariella , Maida Marcello , Orlando Ambrogio 
Published: April 2022

Abstract

Background
Data from the first wave of the coronavirus disease 2019 (COVID-19) pandemic suggested that patients with inflammatory bowel disease (IBD) are not at higher risk of being infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population and that a worse prognosis is not associated with immunomodulatory drugs, with the possible exception of systemic steroids.

Methods
This retrospective, observational study included consecutive IBD patients from the Sicilian Network for Inflammatory Bowel Disease (SN-IBD) cohort who had a SARS-CoV-2 infection diagnosis (polymerase chain reaction–confirmed presence of the viral genome in a nasopharyngeal swab) during the second COVID-19 pandemic wave (September 2020 to December 2020). Data regarding demographics, IBD features and treatments, and comorbidities were analyzed in correlation with COVID-19 clinical outcomes.

Results
Data on 122 patients (mean age, 43.9 ± 16.7 years; males, 50.0%; Crohn’s disease, 62.3%; ulcerative colitis, 37.7%) were reported. Twelve patients developed COVID-19-related pneumonia (9.8%), 4 (3.3%) required respiratory assistance (nonmechanical ventilation or orotracheal intubation), and 4 died (case fatality rate, 3.3%). In a multivariable analysis, age (odds ratio [OR], 1.034; 95% CI, 1.006–1.147; P = .032) and severe IBD activity (OR, 13.465; 95% CI, 1.104–164.182; P = .042) were independent predictors of COVID-19-related pneumonia, while severe IBD activity (OR, 15.359; 95% CI, 1.320–178.677; P = .030) was the only independent predictor of severe COVID-19, a composite endpoint defined as the need for respiratory assistance or death. A trend towards a protective role of tumor necrosis factor α inhibitors on pneumonia development was reported (P = .076).

Conclusions
In this cohort of patients with IBD and SARS-CoV-2 infection, severe IBD activity was the only independent risk factor for severe COVID-19.
Evaluation of Kinesiophobia in Survivors of Major Burn Injury
Authors: Jeong Won J , Holavanahalli Radha K , Kowalske Karen J 
Published: April 2022

Abstract
Kinesiophobia, the fear of movement and reinjury, has not been described in burn injury survivors. Physical activity is a key component of burn rehabilitation programs. Yet, not all burn survivors exercise at the recommended level. This is an exploratory study examining the association of the demographics and injury characteristics of burn survivors with a fear of movement. The subjective fear of movement was measured using the Tampa Scale for Kinesiophobia (TSK). The TSK score was compared between several demographics and injury characteristics by performing the independent sample t-test. Sixty-six percent of subjects in our study (n = 35), reported high levels of kinesiophobia (score 37 or above). The mean scores of the TSK were greater in males (40.7), non-white (43.0), Hispanic/Latino (41.1), age greater than 50 years (42.3), and TBSA burn of &gt;15% compared to females (36.9), white (38.5), non-Hispanic/Latino (39.3), age 50 years or less (38.1), and TBSA 15% or less (39.4), respectively. However, with the exception of time postinjury, none of the mean differences were statistically significant. Subjects who had sustained a burn injury more than 12 months ago showed higher levels of kinesiophobia than the subjects who were injured within 12 months with a mean difference of 7.35 (P = .01). Thus, this study highlights the importance of 1) continued, long-term follow-up for burn survivors, and 2) appropriate educational and treatment interventions to address any underlying existing, new, or emerging medical issues that may contribute to the fear or avoidance of movement.
Phase arrival picking for bridging multi-source downhole microseismic data using deep transfer learning
Authors: Zhang Yilun , Leng Jiaxuan , Dong Yihan , Yu Zhichao , Hu Tianyue , He Chuan 
Published: April 2022

AbstractThe phase arrival picking of the downhole microseismic dataset is a critical step in fracturing monitoring data processing. Recently, data-driven methods have been widely used in seismology studies, especially in seismic phase picking. The picking results heavily depend on whether large quantities of accurately labeled phase samples could be obtained to extract the characteristics of seismic waveforms. Also, there is a shortcoming of poor generalization ability in dealing with the cross-source transfer scenarios. In this paper, we propose a novel deep transfer learning method for microseismic phase arrival picking by fine-tuning one existing pretrained model based on a few phase samples. The pretrained model, which has been domain-adapted for phase picking, adopts 2D U-Net to both extract time and space features, thereby improving the overall picking accuracy. Moreover, the fully convolutional U-Net architecture has the ability to handle samples with variable sizes so could be used for bridging downhole microseismic data from different sources. The results of two transfer cases show that compared with the direct application of the pretrained model and a newly trained model, the proposed method could provide more satisfactory performance with only limited seismic phase samples. Also, our method significantly reduces the cost of labeling and saves time because of avoiding repeated training.
Association Between State Hepatitis A Vaccination Requirements and Hepatitis A Vaccination Rates
Authors: Choi Yoonyoung , Bhatti Alexandra , Liu Zhiwen , Ruch Alex , Skolnik Ava , Carias Cristina , Goveia Michelle G , Simon Jakub K 
Published: April 2022

Abstract
Using National Immunization Survey Child and Teen (2008-2017), we associated state vaccination requirements with hepatitis A (Hep A) vaccination rates in children and adolescents. States with school entry or both childcare and school entry requirements were associated with 35%-40% higher Hep A vaccination rates, compared with states without such requirements.
What Really Matters for Supervision Training Workshops? A Realist Evaluation
Authors: Nguyen Van N.B. , Rees Charlotte E. , Ottrey Ella , Davis Corinne , Pope Kirsty , Lee Sarah , Waller Susan , Palermo Claire 
Published: April 2022

Purpose
Supervision training supports health care supervisors to perform their essential functions. Realist evaluations are increasingly popular for evaluating complex educational interventions, but no such evaluations exist appraising supervision workshops. Building on an earlier realist synthesis of supervision training, the authors evaluated whether supervision workshops work, for whom and under what circumstances, and why.

Method
The authors conducted a 2-stage realist evaluation during 2018–2019 to refine and develop program theory. The intervention involved half-day, face-to-face supervision workshops as part of an Australian state-wide government-funded program for health care and human services supervisors. Data collection involved realist interviews with 10 workshop developers (stage 1) and 43 supervisors (stage 2). The authors employed team-based data analysis using realist logic to refine and develop program theory by identifying contexts, mechanisms, outcomes, and context-mechanism-outcome configurations.

Results
Despite their brevity, the supervision workshops had many reported benefits for supervisors (e.g., improved satisfaction) through various perceived mechanisms pertaining to pedagogy (e.g., mixed pedagogies), workshops (e.g., optimal duration), and individuals (e.g., supervisor engagement). However, they also yielded negative reported outcomes (e.g., suboptimal knowledge gains) brought about by assorted perceived mechanisms related to pedagogy (e.g., suboptimal peer learning), workshops (e.g., content irrelevance), and individuals (e.g., suboptimal facilitator competence). Such mechanisms were thought to be triggered by diverse contexts including supervisors’ levels of experience, sector, and workplace supervision cultures.

Conclusions
While the findings partly support the realist synthesis of supervision training and previous realist evaluations of faculty development, this realist evaluation extends this literature considerably. Health care educators should employ mixed pedagogies (e.g., didactic teaching, peer learning), relevant content, optimal workshop duration, and competent/engaging facilitators. Educators also need to tailor workshops according to supervisors’ contexts including the sectors and supervision cultures in which supervision is practiced, and supervisors’ levels of experience (e.g., experienced supervisors appreciated workshop brevity).
Factors Which Predict Adverse Outcomes in Anterior Cervical Discectomy and Fusion Procedures in the Nonelderly Adult Population
Authors: Rodrigues Adrian J. , Jokhai Rayyan , Varshneya Kunal , Stienen Martin N. , Veeravagu Anand 
Published: April 2022

Study Design:
Retrospective cohort.

Objective:
The largest published cohort of anterior cervical discectomy and fusion (ACDF) patients was queried to better characterize demographic and operative factors that predict 90-day complication and 2-year reoperation risk.

Summary of Background Data:
The MarketScan Database was queried from 2007 to 2016 to identify adult patients until 65 years, who underwent an ACDF procedure using International Classification of Diseases 9th Version (ICD-9) and Current Procedural Terminology (CPT) codes. MarketScan is a national insurance claims database that contains millions of patient records across all 50 states.

Methods:
Multivariate logistic regression was used to identify factors associated with complications until 90 days and reoperations until 2 years.

Results:
Of 138,839 ACDF procedures, 8500 patients (6.1%) experienced a complication within 90 days of the ACDF, and 7433 (5.4%) underwent surgical revision by 2 years. While the use of anterior cervical plating did not predict 2-year reoperation, it was associated with dramatically reduced 90-day complication risk (adjusted odds ratio [aOR]: 0.32; 95% confidence interval [CI]: 0.30–0.34; P<0.001). Upon multivariate analysis, female sex (aOR: 0.83; 95% CI: 0.79–0.87; P<0.001) was associated with decreased risk of 2-year reoperation, while depression predicted a 50% increase in reoperation risk (aOR: 1.51; 95% CI: 1.43–1.59; P<0.001). The single largest factor associated with reoperation risk, however, was the presence of a 90-day postoperative complication (aOR: 1.79; 95% CI: 1.66–1.94; P<0.001).

Conclusion:
Increased patient comorbidities and the use of bone morphogenic protein were found to increase the risk for postoperative complications, while cervical plating was associated with a strong decline in this risk. In addition, poor patient mental health outweighed the adverse of impact of other comorbidities on 2-year revision risk. The presence of a postoperative complication was the key modifiable risk factor associated with reoperation risk. Conclusions from this study may help surgeons better identify high-risk ACDF patients for more careful patient selection, counseling, informed consent, and management.
Changes in Survival Outcomes of Patients With Neuroendocrine Neoplasms Over the Past 15 Years
Authors: Abdel-Rahman Omar , Pham Truong-Minh , Pokhrel Arun , Ruether Dean , Sawyer Michael B. 
Published: April 2022

Background:
The past 2 decades have observed a number of advances in therapeutic approaches to patients with neuroendocrine neoplasms (NENs). This study aims to assess whether survival outcomes have changed among patients with NENs over the past 15 years, in a real-world, population-based study.

Materials and Methods:
We accessed administrative databases within the province of Alberta, Canada, and we reviewed patients with invasive NENs diagnosed 2004 to 2019. Patients were classified according to the year of diagnosis into 3 groups: 2004 to 2008; 2009 to 2013; and 2014 to 2019. Kaplan-Meier survival estimates were used to compare overall survival (OS) according to different baseline characteristics (including the year of diagnosis). Multivariable Cox regression modeling was used to examine factors associated with the risk of death in this cohort.

Results:
We included a total of 3431 patients in the study cohort. Using multivariable Cox regression analysis, the following factors were associated with worse survival: older age at diagnosis (hazard ratio [HR]: 3.45; 95% CI [confidence interval]: 2.74-4.35), male sex (HR: 1.38; 95% CI: 1.21-1.56), lung primary site (HR for lung vs. appendicular primary: 1.39; 95% CI: 1.01-1.92), Stage 4 disease (HR: 2.80; 95% CI: 2.38-3.30), South zone of the province (HR for South zone vs. Calgary zone: 1.85; 95% CI: 1.49-2.30), and higher comorbidity index (HR for ≥3 vs. 0: 2.66; 95% CI: 2.19-3.24). Although Kaplan-Meier method showed significant difference in OS according to diagnosis period, multivariable regression model showed that the period of diagnosis did not appear to impact OS (HR for diagnosis period 2004 to 2009 vs. 2014 to 2019: 1.04; 95% CI: 0.89-1.22).

Conclusions:
Over the study period (2004 to 2019), patients diagnosed during later periods did not appear to experience better OS compared with patients diagnosed at an earlier time.
Skin Preservation in the Debridement of Necrotizing Fasciitis: A Demonstrative Case Report
Authors: AlMarshad Felwa A. , Shah Mardan Qutaiba N. M. , Mahabbat Nehal A. , Ijaz Attiya , Bashaweeh Rahaf , Mrad Mohamed Amir , Al-Qattan Mohammad M. , Hashem Fuad K. 
Published: April 2022

Summary:
Necrotizing fasciitis (NF) is a rare yet potentially fatal soft-tissue, polymicrobial infection. Aggressive debridement of the fascia and overlying skin as well as antimicrobial coverage constitute the mainstay of management, often leaving large skin defects. However, we demonstrate in this paper a case of a young woman who developed NF after liposuction and was treated by fascial debridement with minimal skin excision. Skin preservation will reduce the morbidity and improve the final aesthetic outcome.
Hybrid Nasal Filler: Combining Agarose Gel and Hyaluronic Acid for Nonsurgical Rhinoplasty
Authors: Buhsem Omer , Kirazoglu Ahmet 
Published: April 2022

Introduction:
Given its structural properties, it would be a mistake to assume that a single type of filler fits perfectly to each anatomical region of the nose in nonsurgical rhinoplasty procedures. Therefore, we aimed to develop a hybrid treatment model by applying two different structural types of fillers. Hyaluronic acid (HA), a hydrophilic material, and agarose gel (AG), a nonhydrophilic and high G-prime material, were used in the study according to their advantages and disadvantages.

Methods:
Patients who presented to the office desiring filler treatment for nonsurgical correction of the nose in a 2-year period were enrolled in the study. HA was used intradermally 0.1 ml per each point in the tip defining points and supratip. Injections of 0.4–0.7 and 0.4–0.6 ml AG were used supraperiosteally in the radix and nasal spine, respectively. Clinical improvement was evaluated two weeks later using the Global Aesthetic Improvement Scale from 1 to 5 (1: exceptional improvement; 5: worsened patient). Patient satisfaction was evaluated on a scale from 0 to 10 (0: not satisfied; 10: very satisfied).

Results:
A total of 32 patients (mean age: 27 years) were enrolled in the study. Mean score of patient satisfaction was 9.09 of 10 after injection and 9 of 10 after 2 weeks. Clinical evaluation scores after injection were 1.72 of 5 and 1.69 of 5 on the Global Aesthetic Improvement Scale. No major complication was observed.

Conclusion:
The HA and AG filler hybrid concept applied in different anatomical locations represents a safe and convenient option for nonsurgical rhinoplasty procedures.
MACULAR THICKNESS BY USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IN CHILDREN AND ADOLESCENTS
Authors: Hashemi Hassan , Khabazkhoob Mehdi , Heydarian Samira , Emamian Mohammad Hassan , Fotouhi Akbar 
Published: April 2022

Purpose:
To determine the distribution of macular and cube thickness and their normal range in the students aged 9 years to 15 years and to investigate their associated demographic and biometric factors.

Methods:
This study was based on the data of the second phase of the Shahroud School Children Eye Cohort Study, conducted in 2018. After measurements of visual acuity, biometry, and subjective and cycloplegic refraction, retinal examination was performed using the Zeiss Cirrus HD 4000 optical coherence tomography.

Results:
The data of 5,043 right eyes were analyzed after applying the exclusion criteria. The central macular thickness was 239 ± 19.35 μm. The mean cube volume and cube thickness were 9.94 ± 0.44 and 278 ± 12.20, respectively. According to multiple linear regression analysis, the central macular thickness was significantly lower in girls (coefficient [β]: −9.18; P < 0.001) and rural students (β: 3.86; P < 0.001) and had a direct association with axial length (β: 5.19; P < 0.001), lens thickness (β: 5.33; P = 0.003), and mean keratometry (β: 2.41; P < 0.001). The cube volume was lower in girls (β: −0.13; P < 0.001) and higher in rural students (β: 0.05; P < 0.001).

Conclusion:
Macular thickness was slightly higher in Iranian children. Sex, living place, axial length, lens thickness, and mean keratometry were the main associated factors with macular thickness.
“Listen to me, learn from me”: a priority setting partnership for shaping interdisciplinary pain training to strengthen chronic pain care
Authors: Slater Helen , Jordan Joanne E. , O'Sullivan Peter B. , Schütze Robert , Goucke Roger , Chua Jason , Browne Allyson , Horgan Ben , De Morgan Simone , Briggs Andrew M. 
Published: April 2022

Abstract
What are the care-seeking priorities of people living with chronic pain and carers and how can these shape interdisciplinary workforce training to improve high-value pain care? Phase 1: Australian people living with chronic pain (n = 206; 90% female) and carers (n = 10; 40% female) described their pain care priorities (eDelphi, round 1). A coding framework was inductively derived from 842 pain care priorities (9 categories, 52 priorities), including validation; communication; multidisciplinary approaches; holistic care; partnerships; practitioner knowledge; self-management; medicines; and diagnosis. Phase 2: In eDelphi round 2, panellists (n = 170; valid responses) rated the importance (1 = less important; 9 = more important) of the represented framework. In parallel, cross-discipline health professionals (n = 267; 75% female) rated the importance of these same priorities. Applying the RAND-UCLA method (panel medians: 1-3: “not important,” 4-6: “equivocal,” or 7-9: “important”), “important” items were retained where the panel median score was >7 with panel agreement ≥70%, with 44 items (84.6%) retained. Specific workforce training targets included the following: empathic validation; effective, respectful, safe communication; and ensuring genuine partnerships in coplanning personalised care. Panellists and health professionals agreed or strongly agreed (95.7% and 95.2%, respectively) that this framework meaningfully reflected the importance in care seeking for pain. More than 74% of health professionals were fairly or extremely confident in their ability to support care priorities for 6 of 9 categories (66.7%). Phase 3: An interdisciplinary panel (n = 5) mapped an existing foundation-level workforce training program against the framework, identifying gaps and training targets. Recommendations were determined for framework adoption to genuinely shape, from a partnership perspective, Australian interdisciplinary pain training.
Differential prognoses among male and female patients with hepatocellular carcinoma
Authors: Liao Cheng-Yen , Lee Chun-Yang , Wei Cheng-Yi , Chao Yee , Huang Yi-Hsiang , Hou Ming-Chih , Su Yu-Hui , Wu Jaw-Ching , Su Chien-Wei 
Published: April 2022

Background:
The incidence of hepatocellular carcinoma (HCC) is significantly higher in men than women. Nonetheless, the impact of sex disparities on HCC outcomes remains unclear. We aimed to compare the clinical manifestations and prognoses between male and female patients with HCC.

Methods:
This retrospective study enrolled 5337 consecutive patients (3976 men, 1361 women) who were diagnosed with HCC from 2007 to 2020. The prognostic factors were identified by the Cox proportional hazards model.

Results:
Male patients were younger upon HCC diagnosis (median age 64 vs 69 years; p < 0.001) with more favorable hepatic functional reserves (39.0% vs 35.1% albumin-bilirubin grade 1; p = 0.025) but had greater tumor burdens than the female patients. Furthermore, fewer male patients underwent curative therapies for HCC compared with the female patients (49.0% vs 57.0%; p < 0.001). After a median follow-up of 20.1 months (interquartile range, 5.8-47.3 months), 3133 patients died. The cumulative 5-year overall survival rates were 37.1% and 41.9% for male and female patients, respectively (p < 0.001). From the multivariate analysis, male sex was not an independent factor predictive of poor overall survival in all patients and in the subgroup analysis stratified by treatment modalities. When stratified by age, the female sex was an independent factor associated with lower mortality in younger (≤50 years) patients but not in older patients with HCC.

Conclusion:
Sex was not an independent predictor of the outcome of patients with HCC, especially for those aged more than 50 years.