bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic effects of cupping therapy in frozen shoulder: a review article
Authors: SHARMA RITA 
Published: August 2022

ABSTRACT
Frozen shoulder is a chronic aseptic inflammation caused by injury and degeneration of shoulder capsule and periarthritic soft tissue (including ligaments, muscles, tendons, synovial sacs, etc.). Cupping is gaining popularity in physical medicine due to its ease of use, lack of side effects, and pain relief. This study looked at the efficacy of cupping therapy for treating shoulder pain. However, because very little literature on the efficacy of cupping therapy in the frozen shoulder is available, further research is needed in this field.
Keywords: Cupping therapy, frozen shoulder, adhesive capsulitis, wet cupping therapy, dry cupping.
Preparation of mucoahesive tablets of famotidine by wet granulation method and its in-vitro testing
Authors: Alvi Zainab , Sharmeen Hira , Ayub Alina , Shahid Attia , Dildar Hafiza Nida , Imtiaz Mahnoor , Ejaz Iqra 
Published: August 2022

Objective: Famotidine is a histamin H2-receptor antagonist.The aim and objective of the present work is toformulate and evaluate mucoadhesive tablets of famotidine. It is also foused on the selection of mucoadhesivepolymer & its activity in various combinations & ratios. The poor bioavialability & shorter half-life suffice thedevelopment of controlled release mucoadhesive formulation. Method: Mucoadhesive tablets each containing 20mg of famotidine were prepared by conventional wet granulation method employing as mucoadhesive materials. A batch of 50 tablets was prepared, in each case a blend of 1 gm of famotidine with different polymers addition indifferent strengths with required 40mg lactose as diluent achieved after titration which were then grannulated along with a solvent blend if water and ethyl alcohol. Results: The flow properties of all five batches were in between fair and passable. Hardness of tablets ranged from 6.9-8.2 kg/cm2 and the percentage friability was between 0.25-0.79 %. The drug content uniformity in the mucoadhesive tablets was 96.49-104.81%. The surface pH study was within the range from 6.7-7.4. From all formulations, over 20% of the famotidine was release within first hour of dissolution study. In the present study the formulation FT04 (tragacanth & HPMC ) has shown cumulative percent drug release of about 80.762% in 12 h. Conclusion: From the results we concluded that formulation containing famotidine with HPMC & tragacanth has given better drug release property than the other four formulations & the wash-off test has shown that this formulation (FT04) has better mucoadhesive property.
Gender Differences in Stress Resistance of Adolescents with Autism Spectrum Disorders
Authors: Yakymchuk Iryna , Vakhotska Iryna , Radzivil Kateryna , Ivashchenko Kateryna , Poliekhina Viktoriia 
Published: August 2022

Objective: The research provided the empirical study of the gender differences in the experience of stress and coping with it in boys and girls diagnosed with high-functioning autism through qualitative methods. Methods: Observation was the main method used in the study, which was implemented by filling in the observation diary by specialists and parents of adolescents with autistic disorders. The main coping strategies under research were addressing others, avoiding the problem, and working on the problem. Content analysis was used as the main data processing method.
Results: The study found some gender differences in coping with stress between males and females. Besides, it was found that the use of certain forms of coping behavior differs depending on age.
Conclusions: The study allowed us to determine that boys tend to choose a strategy of working on the problem in interpersonal interaction, while girls are disposed to avoid the problem. The opposite picture was observed for the social environment: girls with ASD tend to use a strategy of addressing others, and boys avoid the problem through self-isolation.
Langmuir Probes' Secondary Power Supply System for the "Obstanovka" Experiment and Plasma-wave Complex Aboard the Russian Segment of the International Space Station
Authors: Gramatikov Pavlin , Kirov Boian 
Published: August 2022

The Plasma-wave complex is scientific instrumentation for plasma and wave parameters measurements in the vicinity of the International Space Station, and is implemented in the “Obstanovka” experiment aboard the Russian segment.
The Langmuir probes instruments, developed at the Space Research and Technology Institute of the Bulgarian Academy of Sciences, measured the following parameters: electron temperature, electron and ion concentration, plasma and the International Space Station’s surface potential. One of the results is that sharp jumps in the surface potential are detected when crossing the terminator and the Equatorial anomaly.
The Langmuir probes operate outside the Russian “Zvezda” module. Families of voltage-ampere characteristics of the Langmuir probe are measured – when the voltage changes in a certain range, the value of the current flowing is recorded.
There are block and functional diagrams of the instrument Langmuir probes and its secondary power supply system, designed to supply the measuring probe, the analogue and digital circuit boards.
Raking over the ashes: assessing the impact of fire on native fauna in the aftermath of Australia’s 2019–2020 fires
Authors: Dickman Christopher R. , Hutchings Pat , Law Brad , Lunney Daniel 
Published: August 2022

ABSTRACT
The 2021 annual forum of the Royal Zoological Society of NSW raked over the ashes of the unprecedented “Black Summer” bushfires of 2019–2020 in eastern and southern Australia to assess how forest ecosystems and their constituent fauna had fared. This paper provides an overview of the 21 studies that were presented at the forum, now as papers in this theme edition of Australian Zoologist. All the authors were unanimous in their agreement about the unparalleled extent and severity of the fires and the magnitude of their ecological impacts. Whereas much of the focus of the 2019–2020 fires was on vertebrates, significant research was also carried out on a diverse range of invertebrate taxa. The studies of the invertebrate groups found that different taxa respond variably to fire and also emphasised the difficulties in judging the full impact of the fires due to taxonomic impediments. An underlying theme in almost all studies was that long-term and broad-scale monitoring of fauna and faunal habitats is essential if we are to build a robust understanding of how animals respond to fire, and in turn how managers can mitigate the impacts of fire in future. Such monitoring will need to incorporate the effects of other disturbance factors, such as habitat fragmentation, drought, salvage logging and longwall mining, that interact with fire, and also trial new methods to track and assist fauna to cope with the changing fire regimes. Several studies advocated the use of novel and emerging technologies to achieve better monitoring of fauna, while others proposed mapping of large scale, as well as micro-refuges, to maximise fire resilience, or the use of supplementary resources such as nest boxes and artificial roosts to replace those lost in fires. We concur with all the authors that a critically important way to protect and manage our native fauna is through expanded and sustained research and monitoring programs, and by making the key results available to managers and policy makers via peer-reviewed publication.
Perfil‌ ‌e‌ ‌estratégias‌ ‌de‌ ‌famílias‌ de ‌escolas‌ ‌privadas‌ ‌de‌ ‌Belo‌ ‌Horizonte‌ ‌durante‌ ‌a‌ ‌pandemia‌ de COVID-19 ‌
Authors: Quadros João Eduardo 
Published: August 2022

O‌ ‌texto‌ ‌apresenta‌ ‌pesquisa‌ ‌acerca‌ ‌das‌ ‌estratégias‌ ‌educativas‌ ‌empregadas‌ por‌ ‌famílias‌ ‌cujos‌ ‌filhos‌ ‌estavam‌ ‌matriculados‌ ‌em‌ ‌escolas‌ ‌privadas‌ ‌de‌ ‌Belo‌ Horizonte‌ ‌durante‌ ‌o‌ ‌ano‌ ‌de‌ ‌2020,‌ ‌no‌ ‌contexto‌ ‌do‌ ‌ensino‌ ‌remoto‌ ‌imposto‌ ‌pela‌ pandemia‌ ‌de‌ ‌COVID-19.‌ ‌Primeiramente,‌ ‌foi‌ ‌utilizado‌ ‌um‌ ‌questionário‌ ‌digital,‌ objetivando‌ ‌traçar‌ ‌um‌ ‌perfil‌ ‌sociológico‌ ‌dos‌ ‌sujeitos.‌ ‌Em‌ ‌seguida,‌ ‌foram‌ ‌realizadas‌ entrevistas‌ ‌semiestruturadas‌ ‌que‌ ‌visaram‌ ‌conhecer‌ ‌detalhes‌ ‌das‌ ‌estratégias‌ ‌que‌ as‌ ‌famílias‌ ‌utilizavam‌ ‌para‌ ‌lidar com ‌essa‌ ‌modalidade‌ atípica‌ ‌de‌ ‌educação‌ ‌em‌ ‌ambiente‌ ‌doméstico.‌ ‌Os‌ ‌resultados‌ ‌indicam‌ ‌que‌ ‌as‌ ‌famílias‌ convertem‌ ‌as‌ ‌vantagens‌ ‌proporcionadas‌ ‌pelos‌ ‌seus‌ ‌capitais‌ ‌em‌ ‌estratégias‌ educacionais‌ ‌de‌ ‌dimensão‌ ‌material‌ ‌e‌ ‌cultural‌ ‌decisivas‌ ‌para‌ ‌melhor‌ ‌lidar‌ ‌com‌ ‌o‌ contexto‌ ‌adverso‌ ‌do‌ ‌ensino‌ ‌remoto.‌ ‌
Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US
Authors: Lee Phil H. , Doyle Alysa E. , Silberstein Micah , Jung Jae-Yoon , Liu Richard T. , Perlis Roy H. , Roffman Joshua , Smoller Jordan W. , Fava Maurizio , Kessler Ronald C. 
Published: August 2022

ImportanceSuicide rates have been increasing among youth in the US. While the heritability of suicide risk is well established, there is limited understanding of how genetic risk is associated with suicidal thoughts and behaviors in young children.ObjectiveTo examine whether genetic susceptibility to suicide attempts (SAs) is associated with suicidal thoughts and behaviors in children.Design, Setting, and ParticipantsThis case-control study examined data from the Adolescent Brain Cognitive Development (ABCD) study, a population-based longitudinal study of 11 878 US children enrolled at age 9 and 10 years from September 2016 to November 2018. Youth reports of suicidal ideation (SI) and SAs were obtained from the Kiddie Schedule for Affective Disorder and Schizophrenia at baseline and 2 subsequent years. After conservative quality control of genotype data, this analysis focused on 4344 unrelated individuals of European ancestry. Data analysis was conducted from November 2020 to February 2022.Main Outcomes and MeasuresChildren’s lifetime experiences of SI and SAs were assessed each year from ages 9 to 10 years to ages 11 to 12 years. Polygenic risk scores (PRSs) for SAs were calculated for ABCD study participants based on the largest genome-wide association study of SA cases and controls of European ancestry (total sample n = 518 612).ResultsOf 4344 children of European ancestry (2045 [47.08%] female; mean [SD] age, 9.93 [0.62] years), significant associations were found between children’s SA PRSs and their lifetime SAs with the most robust association in the follow-up year 2 (odds ratio, 1.43 [95% CI, 1.18-1.75]; corrected P = 1.85 × 10−3; Nagelkerke pseudo R2 = 1.51%). These associations remained significant after accounting for children’s sociodemographic backgrounds, psychopathology symptoms, parental histories of suicide and mental health, and PRSs for major depression and attention-deficit/hyperactivity disorder (likelihood ratio test P &amp;lt; .05). Children’s depressive mood and aggressive behavior were the most significant partial mediators of SA genetic risk on SAs (mediation analysis P &amp;lt; 1 × 10−16). Children’s behavioral problems, such as attention problems, rule-breaking behavior, and social problems, also partially mediated the association of SA PRSs with SAs (mediation analysis false discover rate &amp;lt; 0.05).Conclusions and RelevanceThis study’s findings indicate that there may be genetic factors associated with SA risk across the life span and suggest behaviors and conditions through which the risk could be mediated in childhood. Further research is warranted to examine whether incorporating genetic data could improve the identification of children at risk for suicide.
Many‐Body Molecular Interactions in a Memristor
Authors: Rath Santi P. , Thompson Damien , Goswami Sreebrata , Goswami Sreetosh 
Published: August 2022

AbstractElectronic transitions in molecular‐circuit elements hinge on complex interactions between molecules and ions, offering a multidimensional parameter space to embed, access, and optimize material functionalities for target‐specific applications. This opportunity is not cultivated in molecular memristors because their low‐temperature charge transport, which is a route to decipher molecular many‐body interactions, is unexplored. To address this, robust, temperature‐resilient molecular memristors based on a Ru complex of an azo aromatic ligand are designed, and current–voltage sweep measurements from room temperature down to 2 K with different cooling protocols are performed. By freezing out or activating different components of supramolecular dynamics, the local Coulombic interactions between the molecules and counterions that affect the electronic transport can be controlled. Operating conditions are designed where functionalities spanning bipolar, unipolar, nonvolatile, and volatile memristors with sharp as well as gradual analog transitions are captured within a single device. A mathematical design space evolves, thereof comprising 36 tuneable parameters in which all possible steady‐state functional variations in a memristor characteristic can be attainable. This enables a deterministic design route to engineer neuromorphic devices with unprecedented control over the transformation characteristics governing their functional flexibility and tunability.
Strategies for Improving Solubility of Redox‐Active Organic Species in Aqueous Redox Flow Batteries: A Review
Authors: Wang Xiao , Gautam Rajeev K. , Jiang Jianbing “Jimmy” 
Published: August 2022

AbstractRedox flow batteries (RFB) have emerged as one of the most promising technologies for large‐scale energy storage owing to their high safety, long operation life, and decoupled design of energy and power. However, the problems of high cost and low energy density restrict their further development. The cost merit and tunable structure of organic redox‐active materials have prompted the development of organic RFBs. The solubility of the redoxmer is recognized as a parameter that contributes directly to the energy density. Herein, we focus on strategies for enhancing the solubility of organic redoxmers in aqueous RFBs. The effects of incorporating different hydrophilic functional groups on the solubility of the redoxmer and its effect on the performance of other batteries are systematically and exhaustively described. Other strategies, such as molecular symmetry tuning and employing more soluble counterions and cosolvents, are also summarized. The development trends and prospects for organic RFBs are also discussed.
All‐in‐one microfluidic design to integrate vascularized tumor spheroid into high‐throughput platform
Authors: Kim Youngtaek , Ko Jihoon , Shin Nari , Park Seonghyuk , Lee Seung‐Ryeol , Kim Suryong , Song Jiyoung , Lee Seokjun , Kang Kyung‐Sun , Lee Jeeyun , Jeon Noo Li 
Published: August 2022

AbstractThe development of a scalable and highly reproducible in vitro tumor microenvironment (TME) platform still sheds light on new insights into cancer metastasis mechanisms and anticancer therapeutic strategies. Here, we present an all‐in‐one injection molded plastic array three‐dimensional culture platform (All‐in‐One‐IMPACT) that integrates vascularized tumor spheroids for highly reproducible, high‐throughput experimentation. This device allows the formation of self‐assembled cell spheroids on a chip by applying the hanging drop method to the cell culture channel. Then, when the hydrogel containing endothelial cells and fibroblasts is injected, the spheroid inside the droplet can be patterned together in three dimensions along the culture channel. In just two steps above, we can build a vascularized TME within a defined area. This process does not require specialized user skill and minimizes error‐inducing steps, enabling both reproducibility and high throughput of the experiment. We have successfully demonstrated the process, from spheroid formation to tumor vascularization, using patient‐derived cancer cells (PDCs) as well as various cancer cell lines. Furthermore, we performed combination therapies with Taxol (paclitaxel) and Avastin (bevacizumab), which are used in standard care for metastatic cancer. The All‐in‐One IMPACT is a powerful tool for establishing various anticancer treatment strategies through the development of a complex TME for use in high‐throughput experiments.
Modeling of Batch Organic Dye Adsorption Using Modified Metal‐Organic Framework‐5
Authors: Dahlan Irvan , Wan Mazlan Wan Hamizan , Mulkan Andi , Zwain Haider M. , Hassan Siti Roshayu , Aziz Hamidi Abdul , Hasan Harahsheh Yazeed Ahmad , Zekker Ivar 
Published: August 2022

AbstractModeling and simulation of batch adsorption of the organic dye methylene blue (MB) by modified metal‐organic framework‐5 (MOF‐5) were investigated. The reported data on the adsorption of MB dye onto Wells‐Dawson acids (H6P2W18O62)‐immobilized MOF‐5 were employed. The film‐pore diffusion model was developed based on external mass transfer coefficient and pore diffusion coefficient that govern the mass transfer process in batch organic dye adsorption. Applying the estimated parameters, the MB adsorption by using modified MOF‐5 was examined to evaluate the effects of MOF‐5 modification, initial dye concentration, temperature, and the dosage of adsorbent. The adsorption capacity of modified MOF‐5 (H6P2W18O62/MOF‐5) was higher than pure MOF‐5. Besides, a lower initial MB dye concentration, higher temperature, and lower adsorbent dosage resulted in higher MB dye adsorption capacity.
Computational Insights of Selective Intramolecular O‐atom Transfer Mediated by Bioinspired Copper Complexes
Authors: Gamboa‐Ramirez Stefani , Faure Bruno , Réglier Marius , Simaan A. Jalila , Orio Maylis 
Published: August 2022

AbstractThe stereoselective copper‐mediated hydroxylation of intramolecular C−H bonds from tridentate ligands is reinvestigated using DFT calculations. The computational study aims at deciphering the mechanism of C−H hydroxylation obtained after reaction of Cu(I) precursors with dioxygen, using ligands bearing either activated (L1) or non‐activated (L2) C−H bonds. Configurational analysis allows rationalization of the experimentally observed regio‐ and stereoselectivity. The computed mechanism involves the formation of a side‐on peroxide species (P) in equilibrium with the key intermediate bis‐(μ‐oxo) isomer (O) responsible for the C−H activation step. The P/O equilibrium yields the same activation barrier for the two complexes. However, the main difference between the two model complexes is observed during the C−H activation step, where the complex bearing the non‐activated C−H bonds yields a higher energy barrier, accounting for the experimental lack of reactivity of this complex under those conditions.
Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends
Authors: Wang Yanping , Gao Yanfeng , Song Yujun 
Published: August 2022

AbstractUrine biopsy, allowing for the detection, analysis and monitoring of numerous cancer‐associated urinary biomarkers to provide insights into cancer occurrence, progression and metastasis, has emerged as an attractive liquid biopsy strategy with enormous advantages over traditional tissue biopsy, such as non‐invasiveness, large sample volume, and simple sampling operation. Microfluidics enables precise manipulation of fluids in a tiny chip and exhibits outstanding performance in urine biopsy owing to its minimization, low cost, high integration, high throughput and low sample consumption. Herein, we review recent advances in microfluidic techniques employed in urine biopsy for cancer detection. After briefly summarizing the major urinary biomarkers used for cancer diagnosis, we provide an overview of the typical microfluidic techniques utilized to develop urine biopsy devices. Some prospects along with the major challenges to be addressed for the future of microfluidic‐based urine biopsy are also discussed.
Doping Mo into NiFe LDH/NiSe Heterostructure to Enhance Oxygen Evolution Activity by Synergistically Facilitating Electronic Modulation and Surface Reconstruction
Authors: Gan Yonghao , Li Zhi , Ye Ying , Dai Xiaoping , Nie Fei , Yin Xueli , Ren Ziteng , Wu Baoqiang , Cao Yihua , Cai Run , Zhang Xin , Song Weiyu 
Published: August 2022

AbstractIt is of great significance to design highly efficient electrocatalysts with abundant earth elements instead of precious metals for water splitting. Herein, Mo‐doped NiFe‐layered double hydroxides/NiSe heterostructure (Mo‐NiFe LDH/NiSe) was fabricated by coupling Mo‐doped NiFe LDH and NiSe on nickel foam (NF). The heterostructure electrocatalyst showed ultra‐low overpotential (250 mV) and remarkable durability for oxygen evolution reaction (OER) at 150 mA cm−2. Both theoretical and experimental results confirmed that Mo doping and interfacial synergism induced the interfacial charge redistribution and the lifted d‐band center to weaken the energy barrier (EB) of the formation of OOH*. Mo doping also facilitated the surface reconstruction of NiFe LDH into Ni(Fe)OOH as the active sites under electro‐oxidation process. This work provides a facile strategy for electronic modulation and surface reconstruction of OER electrocatalyst by transition metal doping and heterostructure generation.
Dealloying‐Derived Porous Spinel Oxide for Bifunctional Oxygen Electrocatalysis and Rechargeable Zinc‐Air Batteries: Promotion of Activity Via Hereditary Al‐Doping
Authors: Wang Mei , Long Yi , Zhao Huifang , Zhang Wenjuan , Wang Liyong , Dong Ruifeng , Hou Hua , Wang Huiqi , Wang Xiaoguang 
Published: August 2022

AbstractThe large‐scale fabrication of highly efficient and low‐cost bifunctional catalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is critical to the development of rechargeable zinc‐air batteries (ZABs). Herein, a scalable dealloying strategy was proposed to obtain hierarchically porous spinel‐type oxide with minor hereditary Al doping. Benefiting from the well‐structured porosity and native dopant, O‐np‐Ni5Co10(Al), namely Al−NiCo2O4, exhibited excellent electrocatalytic ORR and OER activities, giving a small potential gap of 0.71 V. The rechargeable ZAB with O‐np‐Ni5Co10(Al) as cathode catalyst delivered a high specific capacity of 757 mAh g−1, a competitive peak power density of 142 mW cm−2, and a long‐term discharge‐charge cycling stability. Furthermore, density functional theory calculations evidenced that appropriate Al doping into NiCo2O4 could significantly reduce the Gibbs free energy difference to 1.71 eV. This work is expected to inspire the design of performance‐oriented bifunctional electrocatalysts for wider applications in renewable energy systems.