bluuebunny/crossref_metadata_2025_split huggingface dataset:
UNVACCINATED PATIENTS WITH SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES HAVE HETEROGENEOUS AND UNRELATED RISKS OF COVID INFECTION AND POOR OUTCOME
Authors: De Lorenzis Enrico , Parente Paolo , Natalello Gerlando , Soldati Salvatore , Bosello Silvia Laura , Barbara Andrea , Sorge Chiara , Axelrod Svetlana , Verardi Lucrezia , Cerasuolo Pier Giacomo , Peluso Giusy , Gemma Antonella , Davoli Marina , Biliotti Donatella , Bruzzese Vincenzo , Goletti Mauro , Martino Mirko , D’Agostino Maria Antonietta 
Published: May 2022

Abstract
Background: The impact of the severe acute respiratory syndrome Coronavirus 2 disease (COVID-19) pandemic on people with systemic autoimmune rheumatic diseases (SARDs) is not fully established. It is unclear whether SARDs are an independent risk factor for infection and poor outcomes. Methods: Incidence and 30-day outcomes of COVID-19 infection were retrospectively evaluated in 40,490 SARD patients in the Lazio Italian Region and compared to the general population as incidence rate ratio adjusted for demographics and comorbidities (adjIRR). SARD diagnosis and comorbidities were derived from medical administrative records using the Chronic Related Group classification system. Data on COVID-19 infection were derived from a dedicated regional digital network. Results: The COVID-19 infection risk was increased in patients with Psoriatic Arthritis (adjIRR=1.21, 95% CI 1.10-1.33) and Undifferentiated Connective Tissue Disease (adjIRR=1.26, 95% CI 1.03-1.54). The hospitalization risk was higher in patients with Axial Spondylarthritis (adjIRR=2.16, 95% CI 1.45-3.22), and Systemic Vasculitis (adjIRR=1.81, 95% CI 1.07-3.06) while intensive care unit admission risk was higher in Systemic Erythematosus Lupus (adjIRR=3.67, 95% CI 1.52-8.83) and primary Sjögren Syndrome (adjIRR=4.13, 95% CI 1.71-9.96) patients. Increased mortality was reported in patients with Rheumatoid Arthritis (adjIRR=1.50, 95% CI 1.04-2.17), Systemic Erythematosus Lupus (adjIRR=2.67, 95% CI 1.10-6.44), primary Sjögren Syndrome (adjIRR=2.51, 95% CI 1.12-5.62), and Scleroderma (adjIRR=4.60, 95% CI 2.06-10.29). Conclusions: Each SARDs presents a peculiar pattern in terms of increased risk of COVID-19 incidence, hospitalization, intensive care unit admission, and death, that is not linked to the immunosuppressive behaviour of the disease.
Tracing relapse clone reveals complex recurrence patterns of pediatric acute lymphoblastic leukemia
Authors: Jia Mingzhu , Li Wei-Jing , Wang Chan-Jan , Gao Chao , Liu Wei , Zhang Rui-Dong , Cui Lei , Li Zhi-Gang 
Published: May 2022

Abstract
Purpose: The recurrence is a significant impediment to the cure of pediatric acute lymphoblastic leukemia (ALL). We studied the correlation between the changes in the immunoglobulin (Ig)/T-cell receptor (TCR) gene rearrangement patterns and clinical characteristics in the relapsed ALL in children. To determine where the relapsed clone originated, we traced the rearrangements levels dynamically from the initial diagnosis to the relapse. Methods: We used multiplex polymerase reaction (PCR) to detect the Ig/TCR gene rearrangements at diagnosis and relapse. The real-time quantitative polymerase chain reaction (RQ-PCR) was used to monitor quantitative levels. To further investigate the origin of relapsed clones, specific primers were designed based on the new rearrangements at relapse to detect the levels at diagnosis and during the treatment.Results: We found that patients with TCRD gene rearrangements were more likely to lose at relapse (P<0.05). Children with BCP-ALL immunophenotype, WBC<50×109/L and a better prednisone reaction on day eight (PR-8) are inclined to develop new rearrangements at relapse. In addition, children older than six years and relapse within 18 months had higher-level subclones at diagnosis (P<0.05). Finally, relapses with unchanged rearrangements (n=40) were caused by the drug resistance from original clones, with partial loss of rearrangements (n=20) were caused by clonal selection, with new rearrangements (n=25) originated from the initial subclone (9/11) and were the result of clonal selection, and a small proportion (2/11) of the possibility of clonal evolution.Conclusion: Most recurrent pediatric ALL originating from the subclones was caused by the clonal selection.
The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection
Authors: Hazra Tapas , Tapryal Nisha , Chakraborty Anirban , Rayavara Kempaiah , Wakamiya Maki , Islam Azharul , Pan Lang , Hsu Jason , Tat Vivian , Maruyama Junki , Hosoki Koa , Sayed Ibrahim , Alcantara Joshua , Castillo Vanessa , Tindle Courtney , Sarker Altaf , Cardenas Victor , Sharma Gulshan , Alexander Laura Crotty , Sur Sanjiv , Ghosh Gourisankar , Paessler Slobodan , Sahoo Debashis , Ghosh Pradipta , Das Soumita , Boldogh Istvan , Tseng Chien-Te 
Published: May 2022

Abstract
Compromised DNA repair capacity of individuals could play a critical role in the severity of SARS-CoV-2 infection-induced COVID-19. We therefore analyzed the expression of DNA repair genes in publicly available transcriptomic datasets of COVID-19 patients and found that the level of NEIL2, an oxidized base specific mammalian DNA glycosylase, is particularly low in the lungs of COVID-19 patients displaying severe symptoms. Downregulation of pulmonary NEIL2 in CoV-2-permissive animals and postmortem COVID-19 patients validated these results. To investigate the potential roles of NEIL2 in CoV-2 pathogenesis, we infected Neil2-null (Neil2−/−) mice with a mouse-adapted CoV-2 strain and found that Neil2−/− mice suffered more severe viral infection concomitant with increased expression of proinflammatory genes, which resulted in an enhanced mortality rate of 80%, up from 20% for the age matched Neil2+/+ cohorts. We also found that infected animals accumulated a significant amount of damage in their lung DNA. Surprisingly, recombinant NEIL2 delivered into permissive A549-ACE2 cells significantly decreased viral replication. Toward better understanding the mechanistic basis of how NEIL2 plays such a protective role against CoV-2 infection, we determined that NEIL2 specifically binds to the 5’-UTR of SARS-CoV-2 genomic RNA and blocks protein synthesis. Together, our data suggest that NEIL2 plays a previously unidentified role in regulating CoV-2-induced pathogenesis, via inhibiting viral replication and preventing exacerbated proinflammatory responses, and also via its well-established role of repairing host genome damage.
In vivo antiplasmodial potential of Thaumatococcus danielli extracts (Benth.) against Plasmodium berghei
Authors: Olasope Mayowa Anifat , Ojuromi Oladele Teslim , Ajibaye Olusola , Ibidapo Comfort Adejoke 
Published: May 2022

Abstract
Elimination of malaria infection with available antimalarial drugs is threatened by resistance developed by Plasmodium species and requires alternative drugs. Thaumatococcus danielli leaves are traditionally used in some local communities in Nigeria to treat malaria. However, no scientific study has proven this claim. This study evaluated the antiplasmodial activity of T. danielli extracts in Swiss albino mice. Qualitative phytochemical analysis of the choice plant and acute toxicity of its extracts were performed followed by a suppressive test of plant extracts against Plasmodium berghei (NK-65 strain). Parasitaemia, temperature, weight, packed cell volume, and mean survival time of the mice were monitored during the test. Data analysis was executed with a one-way analysis of variance and Tukey’s posthoc test in Windows SPSS version 26.0. Ethyl acetate extract at 800mg/kg body weight had the highest suppressive effect of 67.37% in a dose-dependent pattern (p < 0.001). The extract also prevented the decrease in red blood cells, body temperature and caused an appreciable increase in weight (p > 0.05), making it an ideal antiplasmodial extract. Non-toxic extracts of the test plant had considerable antimalarial efficacy caused by detected phytochemicals associated with antimalarial activity. The bioassay of isolated and characterized active compound(s) of the test plant is necessary for the development of new antimalarial(s) from T. danielli leaves.
Optimization and Production of Holocellulosic Enzyme Cocktail from Fungi Aspergillus Nidulans under Solid-State Fermentation for the Production of Poly(3-Hydroxybutyrate).
Authors: Naitam Mayur G. , Kaushik Rajeev , Tomar Govind Singh 
Published: May 2022

Abstract
Aspergillus nidulans was used in the present study to advance a low cost and efficient enzyme hydrolysis system for the generation of reducing sugars from the lignocellulosic biomass. The fungus was grown on the wheat straw with Reese mineral medium as a wetting agent for the production of the holocellulosic enzyme complex. The enzyme extract from A. nidulans showed maximum specific activity, CMCase 68.58 (± 0.55), FPase 12.0 (± 0.06), xylanase 27.17 (± 0.83) and β-glucosidase 1.89 (± 0.037) employing solid-state fermentation (SSF) at 30°C, pH 6.0 after 216 hr. Initial pH, incubation temperature and time were found to affect final enzyme activity significantly. Enzymatic hydrolysis of pretreated paddy straw resulted in the release of reducing sugars (8.484 to 30.91 mg ml− 1), which were further used to produce poly(3-hydroxybutyrate) using halophilic bacterial isolates. 26.80% and 20.47% PHB of the cell dry weight was accumulated by the bacterium Burkholderia gladioli and Bacillus cereus, respectively. This indicates that the holocellulosic enzyme cocktail has a potential role in the enzymatic hydrolysis of lignocellulosic materials and PHA production from cheaper feedstocks like an agricultural waste.
The Importance of Noise Attenuation Levels in Neonatal Incubators
Authors: Fernández-Zacarías Francisco , Puyana‐Romero Virginia , Hernández-Molina Ricardo 
Published: May 2022

Abstract
Background: It is known that high noise levels can be harmful to the preterm infant, causing physiological and psychological disorders. It is also known that premature babies spend a lot of time in an incubator. In this sense, many studies show that incubator noise levels can range from 45 dB to 70 dB. However, these differences in noise levels depend, fundamentally, on the methodology used, which a very varied. The aim of this study is to know the levels of noise from fan in the incubator itself and how much it is able to isolate the noises coming from the outside. Methods: It were characterized the acoustic behavior of several models of incubators. For this purpose it was measured the incubators noise level within an anechoic chamber. It was also used a 4224 pink noise generating source to determine the isolation levels of the incubators and one microphones inside the incubator and another one outside connect to a SVAN958 noise analyzer. Results: The incubators produced continuous equivalent noise levels of between 53.5 dB and 58 dB. The analysis of isolation showed that the level varied from one incubator to another, between 5.2 dB and 10.4 dB. In addition, the isolation level in one-third octave bands varied from one incubator model to another. Conclusions: Preterm infants in an incubator are exposed to noise levels very far from the international recommendations, even if the incubators are meeting the noise criteria set out in the IEC60601-2-19: 2009 standard of 60 dBA under normal use conditions.
Validity and Reliability of Arabic Translation of Social Media Infidelity-Related Behaviors Inventory (SMIRB)
Authors: Nagar zeinab mohamed El , Aufa: Ola Mohamad , Mohamed Mohamed Youssef 
Published: May 2022

Abstract
BackgroundThere are rising interests in social media research in Arabic countries.Aim of the work:To estimate the reliability, construct validity and factor analysis of the Social Media Infidelity-Related Behaviors Inventory (SMIRB) which constitutes 14 questions form the 7 main items, after translating it to Arabic. Participants and MethodsThe English version of SMIRB was translated into Arabic and verified by 47 bilingual experts. The Arabic version was conducted in electronic format to 269 (females & males, age from 18–60 years old) Egyptian participants who were members at Egyptians social media sites and chat-rooms and were selected randomly. Participants were reassessed 4 weeks after the initial administration of the scale. The Statistical analysis was performed to test-retest reliability, item internal consistency (IIC), interclass correlation (ICC), factor analysis and construct validity.ResultsCronbach’s a coefficient to assess (IIC) was found to be 0.90 and satisfactory for the 14 items constitute SMIRB. It’s14 items met the IIC requirement of correlation ≥ with high ICC (0.965, 95% C.I. (0.954–0.974), p < 0.001. The results indicated good repeatability of the SMIRB and construct validity. Factor analysis revealed good construct validity with one-factor solution strong factors emerged with the same construct, accounting for 51.63% of the variance. Each item loaded highly (≥ 0.45) on the corresponding factor.ConclusionThe Arabic translation of SMIRB is an acceptable, reliable, and valid translated measure to assess the infidelity related behaviors due to social media use. We expect that it will be used widely in Egypt and Arab countries.
Reduced expression of SFRP1 is associated with poor prognosis and promotes cell proliferation in breast cancer – An integrated bioinformatics approach
Authors: Suganya Kanagaraj , Sudha Balraj , Poornima Arumugam , Kumar Nachimuthu Senthil , Sumathi Sundaravadivelu 
Published: May 2022

Abstract
Breast carcinoma is the most frequent form of malignancy in women globally. Exploration of the breast cancer genome tiled the way for the validation of novel cancer biomarkers and to explore various mechanisms involved in the progression of carcinogenesis. The purpose of the research is to find an identification of potential gene linked to breast cancer (BC) progression and prognosis. Three datasets (GSE71053, GSE61724, GSE36295) were downloaded from the Gene Expression Omnibus (GEO) database. An integrated analysis of several gene expression profile datasets was used to find differentially expressed genes (DEGs) in BC and normal breast tissue samples. Protein–protein interaction (PPI) network was used to verify hub genes associated to the pathogenesis and prognosis of BC. The functional enrichment and pathway analysis was performed by FunRich, and cBioPortal. The expression pattern was assessed using COSMIC, GEPIA2 and BC-GenExMiner. The results, revealed that among the hub genes, Secreted Frizzled-related protein 1 (SFRP1) was a negative regulator of the Wnt pathway in breast cancer. Loss of SFRP1 may result in abnormal cellular proliferation, migration, and invasion, may trigger cancer cells, leading to progression of the disease, poor prognosis, and therapy resistance. Lastly, the Kaplan–Meier plotter online database demonstrated that expression levels of the SFRP1 gene were related to lower survival. The findings of this research would provide some directive significance for further investigating the diagnostic and prognostic biomarker to facilitate the molecular targeting therapy of breast cancer; SFRP1 expression may be effective as a novel prognostic biomarker in early breast cancer.
revision of Othiini XXII. A new species, a new synonymy, and additional records of Othius from Northwest Georgia (Coleoptera: Staphylinidae: Staphylininae)
Authors: Assing Volker 
Published: May 2022

A total of 373 specimens of Othius Stephens, 1829 was collected during three field trips to West Georgia conducted in June, July/August, and October 2021. The material is represented by eight species. One of them is described and illustrated: Othius egrisicus spec. nov. (Georgia: Samegrelo-Zemo Svaneti), a representative of the O. crassus group. The following synonymy is proposed: Othius hebes Assing & Solodovnikov, 1998 = O. fastigatus Assing & Solodovnikov, 1998, syn. nov. Two species are recorded for the first time since their respective original descriptions. The distributions of several species endemic in Northwest Georgia are clarified and mapped. The Georgian Othius fauna is currently represented by 16 described species, eleven of them endemic, and the genus as whole currently includes 136 species and subspecies.
Taxonomic acts
Othius egrisicus spec. nov. – urn:lsid:zoobank.org:act:CD95C9DB-D170-4435-AA1B-43DE3338D0BC
revision of Medon. XII. Two new species and a review of the fauna of Georgia (Coleoptera: Staphylinidae: Paederinae)
Authors: Assing Volker 
Published: May 2022

Two species of Medon Stephens, 1833 are described and illustrated: M. steggiae spec. nov. (Northwest Georgia: Samegrelo-Zemo Svaneti, Abkhazia) of the M. fusculus group and M. bisinuatus spec. nov. (China: Zhejiang) of the M. profundus group. A revision of previously examined and recently collected material from Georgia revealed that the fauna of this country currently includes six species and that some of the previous records were based on misidentification. All the known records of the genus from Georgia are mapped.
Taxonomic acts
Medon steggiae spec. nov. – urn:lsid:zoobank.org:act:0B7CD2C8-3487-4873-B6B0-45533697760F Medon bisinuatus spec. nov. – urn:lsid:zoobank.org:act:8D2E686A-AF4B-45DB-AAEE-103EAB99C309
Coupling research on spatio-temporal differentiation of water resources carrying capacity in mature mining cities
Authors: Zhao Shuhang , He Gang 
Published: May 2022

Abstract
Long-term unreasonable mining has seriously affected the water resources quality of mature mining cities, but mining development is an important economic pillar of those cities. The problems between sustainable development of mining cities and environmental protection of water resources need to be solved urgently. Based on the state-danger-immunity (SDI) conceptual framework, this paper constructs the evaluation system of water resources carrying capacity (WRCC), and calculates the temporal and spatial differentiation of WRCC of mature mining cities from 2013 to 2019 by combining the criteria importance through intercriteria correlation (CRITIC) method, catastrophe progression model and coupling degree model. The results show that: (1) except that the WRCC grade of Bozhou rose to overload, the WRCC grade of other cities remained unchanged. Huainan, Chuzhou and Xuancheng all showed a downward trend, Suzhou and Chizhou were relatively stable, and Bozhou showed an upward trend. (2) The WRCC of mature mining cities showed an oblique N-type fluctuation. The change range of water resources quality state was small, and the changes in water resources security danger and water resources risk immunity were completely opposite. (3) The coordinated development of mature mining cities as a whole with Chuzhou and Xuancheng has changed from primary imbalance to severe imbalance. Other cities have been in severe imbalance.
Epistemologias do Sul e a nova Geografia: por uma Geografia Popular no encontro entre Milton Santos e Boaventura de Sousa Santos
Authors: Cerqueira-Neto Sebastião P. G. de 
Published: May 2022

Esta reflexão tem como escopo principal apresentar uma proposta que chamarei de Geografia Popular, que pode ser um caminho para contrapor e, porque não, estreitar ou desmanchar linhas abissais que fragmentam o território do Brasil a partir da sua divisão estadual que estabeleceuma hierarquia o Norte e Sul do país. Para propor essa reflexão sob o olhar de uma geografia popular partir da percepção pessoal que adquiri ao longo dos meus estudos sobre a fragmentaçãodo território nacional, através das “implosões” de alguns estados; busquei na geografia nova de Milton Santos uma outra maneira de interpretar uma geografia que se aproximasse da dinâmica social; e, por último estabeleci um diálogo com as Epistemologias do Sul, teorizada e difundida pelo sociólogo Boaventura de Sousa Santos, que privilegia as experiências dos saberes, das lutas sociais, culturais e ambientais para dar relevo para outros tipos de conhecimentos.
Música e Poder: para uma sociologia da ausência da música portuguesa no contexto europeu de António Pinho Vargas, 2011
Authors: Oliveira Medeiros Ana Judite 
Published: May 2022

No livro Música e Poder, o músico e sociólogo português António Pinho Vargas(2011), centra-se essencialmente na análise do caráter subalterno da música portuguesa da tradição erudita no contexto europeu.
Genocídio na Democracia brasileira
Authors: Conceição Fernando 
Published: May 2022

Aponta-se que um dos fenômenos mais preocupantes da atualidade da democracia no Brasil, e que pode ser estendido aos países da América Latina e do Caribe, é o alto índice de assassinatos, abalando pela criminalidade a vida dois cidadãos, que se sentem desprotegidos pelo Estado que se autodenomina democrático de Direito. O noticiário das chacinas já não provoca reações de indignação na sociedade, que vai se resignando a essa realidade. Discutem-se essas questões a partir de um ensaio e referentes clássicos multidisciplinarese estratégia de pesquisa, da revisão bibliográfica complementada pela analise de dados estatísticos do mapa da violência. Parte-se das hipóteses que os discursos hegemônicos que naturalizariam o status quo da violência nessassociedades pós-coloniais é reflexão que se impõe a partir do imaginário de senso comum acerca do perfil das vítimas em potencial dos homicídios e se os donos do poder, em obediência à tradição secular do Estado brasileiro – patrimonialista, cartorial e herdeiro de uma visão epistemológica fundada no racialismo – são cognitivamente incapacitados para agir na direção de superar o problema. Conclui-se que a população que mais morre são os pobres, negros (ou pretos) e prostitutas, e que isso não causa indignação, pois costuma-se propalar no Brasil, que essas são vítimas históricas preferenciais da violência em um país construído pela violência do escravismo colonial, de família patriarcal e conservadora, entretanto esse fenômeno do genocídio da juventude negra obstrui a qualidade da democracia no Brasil, sendo os estados de maior incidência a Bahia, seguido da Paraíba.
HNF1A-AS1: A Tumor-associated Long Non-coding RNA
Authors: Liu Yuling , Zhao Fangnan , Tan Fangshun , Tang Lu , Du Zhuoying , Mou Jie , Zhou Gang , Yuan Chengfu 
Published: May 2022

Background:
Hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1) is a Long
non-coding RNA (LncRNA) that participates in the occurrence and development of lots of tumors and is supposed
to be a new biomarker. The text aims to illustrate the biological effect, specific mechanism and clinical
significance of HNF1A-AS1 in various tumors.

Methods:
Via consulting the literature, analyze and summarize the relationship between HNF1A-AS1 and all
kinds of tumors and the specific mechanism.

Results:
This is a review paper about the tumor-associated long non-coding RNA HNF1A-AS1. Many researches
show that LncRNA HNF1A-AS1 is related to the development of tumorous tumors. Its expression is
up-regulated in numerous tumors, such as oral squamous cell carcinoma, hepatocellular carcinoma, breast cancer,
osteosarcoma, lung cancer, cervical cancer, bladder cancer, colon cancer, colorectal cancer, oesophageal
adenocarcinoma and laryngeal squamous cell carcinoma. However, HNF1A-AS1 is down-regulated in gastroenteropancreatic,
neuroendocrine neoplasms, oral squamous cell carcinoma. Furthermore, HNF1A-AS1 can
affect tumor proliferation, invasion, migration and apoptosis by targeting some microRNAs-miR-661 and
miR-124. HNF1A-AS1 can also influence the development of tumors by regulating EMT.

Conclusion:
These studies show that LncRNA-HNF1A-AS1 is closely related to the occurrence development
of numerous cancers. Through various molecular mechanisms to regulate tumor growth, HNF1A-AS1 can possibly
become the new biological biomarker and therapeutic target for many kinds of tumors.