bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory Investigation on Pavement Performance of Basalt Fiber-Reinforced Asphalt Mixture Under the Coupling Effect of Freeze-Thaw Cycles and Aging
Authors: Liang Rongwei , Yu Wei , Luo Zengjie 
Published: July 2022

Due to the significant temperature difference and high solar radiation in high-altitude areas, the asphalt pavement has been in freeze-thaw cycles and radiation service conditions for a long time, resulting in a shorter service life. To extend the service life of asphalt pavement in high-altitude areas, this study uses basalt fiber to toughen the asphalt mixture, and the service characteristics of the asphalt pavement under the coupled effects of freeze-thaw cycles and aging were evaluated. First, the freeze-thaw cycles, aging time, and basalt fiber content were selected as independent variables to conduct the Box–Behnken design (BBD) test design. Consequently, the corresponding response surface model was established. Based on the rutting test, three-point bending test, and indirect tensile test, the optimum content of basalt fiber was obtained. Finally, the fatigue properties of the asphalt mixture by the four-point bending fatigue test were compared under the optimum content. The results showed the consequences of freeze-thaw cycles will reduce the road properties of asphalt and give rise to damage to the asphalt; among them, the indirect tensile strength was decreased by 21.7% at most (the number of freeze-thaw cycles from 10 to 30). Aging will reduce the fatigue life of the asphalt mixture, but its dynamic stability, flexural tensile strength, and slitting strength will be enhanced to a certain extent; among them, the dynamic stability can be improved by up to 28.1% (aging from 4 to 12 h). Basalt fiber can increase the flexural tensile strength, dynamic stability, and spitting strength; the optimum content is 0.35% of asphalt mixtures. Furthermore, the fatigue life of basalt fiber-reinforced asphalt mixture can be significantly improved, which can reduce the influence of freeze-thaw cycles and aging. In addition, the unit price of basalt fiber-reinforced asphalt mixture is only 6.9% higher than that of SBS-modified asphalt mixture, which has significant economic benefits. Under experimental conditions, the effect of aging on the properties of the asphalt mixture is greater than that of the freeze-thaw cycle. This research shows that careful consideration of the road behavior of basalt fiber-reinforced asphalt mixture under freeze-thaw cycles and aging is essential for the pavement durability design.
Parity and Metabolic Syndrome Risk: A Systematic Review and Meta-Analysis of 15 Observational Studies With 62,095 Women
Authors: Sun Ming-Hui , Wen Zhao-Yan , Wang Ran , Gao Chang , Yin Jia-Li , Chang Yu-Jiao , Wu Qi-Jun , Zhao Yu-Hong 
Published: July 2022

BackgroundEpidemiological studies have provided inconsistent evidence of the association between parity and metabolic syndrome (MetS) risk. We conducted this first systematic review and meta-analysis to comprehensively and precisely quantify this topic.MethodsComprehensive searches of PubMed, Embase, and the Web of Science databases were conducted to identify observational studies of the association between parity and MetS risk up to 30 January 2022. Study inclusion, data extraction, and quality assessment were checked and reviewed by two investigators independently. Random-effects models were applied to estimate pooled odds ratios (ORs) and 95% CIs. This study has been registered with PROSPERO.ResultsTwo high-quality cohorts and thirteen medium-quality cross-sectional studies involving 62,095 women were finally included. Compared with the nulliparous, the pooled OR of MetS for the ever parity was 1.31 (95% CI = 0.91–1.88, I2 = 72.6%, n = 3). Compared with the lowest parity number, the pooled OR of MetS for the highest parity number was 1.38 (95% CI = 1.22–1.57, I2 = 60.7%, n = 12). For the dose-response analysis, the pooled OR of MetS for each increment of one live birth was 1.12 (95% CI = 1.05–1.19, I2 = 78.6%, n = 6). These findings were robust across subgroups and sensitivity analyses. No evidence of heterogeneity between subgroups was indicated by meta-regression analyses.ConclusionThe findings suggested that parity was associated with an increased risk of MetS. A sufficient number of large prospective cohort studies are required to fully verify our findings.Systematic Review Registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42022307703].
Comparing Standard Keratometry and Total Keratometry Before and After Myopic Corneal Refractive Surgery With a Swept-Source OCT Biometer
Authors: Wang Ziyang , Song Yanzheng , Yang Wenli , Li Dongjun , Chen Wei , Zhao Qi , Liu Qian , Zhai Changbin 
Published: July 2022

BackgroundMore recently, the swept-source OCT biometer-IOLMaster 700 has provided direct total corneal power measurement, named total keratometry. This study aims to evaluate whether standard keratometry (SK) and total keratometry (TK) with IOLMaster 700 can accurately reflect the corneal power changes induced by myopic corneal refractive surgery.MethodsIn this study, the biometric data measured with the swept-source OCT biometer—IOLMaster 700 before and 3 months after the myopic corneal refractive surgery were recorded. The changes of biological parameters, including SK, posterior keratometry (PK), and TK, and the difference between SK and TK were compared. In addition, the changes of SK and TK induced by the surgery were compared with the changes of spherical equivalent at the corneal plane (ΔSEco).ResultsA total of 74 eyes (74 patients) were included. The changes of SK, PK, TK, axial length, anterior chamber depth, and lens thickness after refractive surgery were all statistically significant (all p &lt; 0.01), while the change of white-to-white was not (p = 0.075). The difference between SK and TK was −0.03 ± 0.10D before the corneal refractive surgery and increased to −0.78 ± 0.26D after surgery. The changes of SK and the changes of TK induced by the surgery had a good correlation with the changes of SEco (r = 0.97). ΔSK was significantly smaller than ΔSEco, with a difference of −0.65 ± 0.54D (p &lt; 0.01). However, the difference between ΔTK and ΔSEco (0.10 ± 0.50D) was not statistically significant (p = 0.08).ConclusionsUsing SK to reflect the changes induced by the myopic corneal refractive surgery may lead to underestimation, while TK could generate a more accurate result. The new parameter, TK, provided by the IOLMaster 700, appeared to provide an accurate, objective measure of corneal power that closely tracked the refractive change in corneal refractive surgery.
Epidemiology and Drug Resistance of Fracture-Related Infection of the Long Bones of the Extremities: A Retrospective Study at the Largest Trauma Center in Southwest China
Authors: Zhang Zhengdong , Liu Pan , Wang Wenzhao , Wang Shanxi , Li Bohua , Li Jun , Yang Banyin , Li Mingxin , Li Qin , Yang Hai , Huang Zeyu , Liu Lei 
Published: July 2022

ObjectiveTo describe the demographic characteristics, risk factors, and bacterial resistance of fracture-related infection (FRI) of the long bones of the extremities.Materials and MethodsThis single-center study retrospectively evaluated patients with FRI of the long bones of the extremities at West China Hospital between January 2012 and December 2017, and analyzed the demographic characteristics, risk factors, distribution of pathogenic bacteria, and bacterial drug resistance.ResultsAmong 9,900 patients, 535 patients (5.4%) were diagnosed with FRI. The most common site of FRI was tibiofibular (298, 55.7%), with 424 cases (79.2%) of open fractures, and 282 cases (52.7%) due to traffic injuries. The 41–50 years age group had the highest incidence of FRI with 157 (29.3%) cases. Overall, 546 strains of 52 types of bacteria were detected in FRI patients, with 105 strains of multidrug-resistant (MDR) bacteria. Methicillin-resistant Staphylococcus aureus (48, 8.8%) and extended-spectrum-β-lactamase Escherichia coli (32, 5.8%) accounted for the largest proportion. Multivariate logistic regression analysis showed that sex (odds ratio [OR] 1.813; 95% confidence interval [CI], 1.071∼3.070; P = 0.027) and fracture type (OR 3.128; 95% CI, 1.683∼5.815; P &lt; 0.001) were independent risk factors for monomicrobial infection (MI). Female sex (OR 4.190; 95% CI, 1.212∼14.486; P = 0.024) was an independent risk factor for polymicrobial infection (PI).ConclusionThis study clarified the infection rates, changes in the bacterial spectrum, and drug resistance characteristics, and risk factors of FRI of the long bones of the extremities in the largest trauma center in southwest China.
Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice
Authors: He Zhuoen , Zeng Yunong , Li Shuyu , Lin Lizhen , Zhou Ruisi , Wang Fangzhao , Yang Wenjiao , Wu Yuhao , Yang Junhao , Chen Ali , Wang Zhang , Yang Hong , Zhao Xiaoshan , Xiao Wei , Li Lei , Gong Shenhai 
Published: July 2022

Background and AimsDrug-induced liver injury (DILI) is a common cause of acute liver failure and represents a significant global public health problem. When discussing the gut-liver axis, although a great deal of research has focused on the role of gut microbiota in regulating the progression of DILI, the gut commensal fungal component has not yet been functionally identified.MethodsMice were pretreated with fluconazole (FC) to deplete the gut commensal fungi and were then subject to acetaminophen (APAP) gavage. In addition, transcriptome sequencing was performed to identify differentially expressed genes (DEGs) between control and fluconazole-pretreated groups of the mice challenged with APAP.ResultsGut commensal fungi ablation through fluconazole pretreatment predisposed mice to APAP-induced hepatotoxicity, characterized by elevated serum liver enzyme levels and more severe centrilobular necrosis, which appears to be caused by robust inflammation and oxidative stress. The 16S rDNA sequencing results indicated that Akkermansia muciniphila abundance had significantly decreased in gut fungi-depleted mice, whereas increased abundance of Helicobacter rodentium was observed. The gene interaction network between DEGs identified by the transcriptome sequencing highlighted a significant enrichment of Cyp2a5 in the liver of APAP-treated mice that were preadministrated with fluconazole. Pharmacological inhibition of Cyp2a5 by 8-methoxypsoralen (8-MOP) could significantly attenuate hepatic inflammation and oxidative stress in mice, thereby conferring resistance to acute liver injury caused by APAP administration.ConclusionOur data highlighted the significance of gut commensal fungi in hepatic inflammation and oxidative stress of APAP mice, shedding light on promising therapeutic strategies targeting Cyp2a5 for DILI treatment.
Association of Plasma and Electroencephalography Markers With Motor Subtypes of Parkinson’s Disease
Authors: Yang Xiaoxia , Li Zhen , Bai Lipeng , Shen Xiao , Wang Fei , Han Xiaoxuan , Zhang Rui , Li Zhuo , Zhang Jinghui , Dong Mengmeng , Wang Yanlin , Cao Tingyu , Zhao Shujun , Chu Chunguang , Liu Chen , Zhu Xiaodong 
Published: July 2022

ObjectiveThe aim of this study was to investigate the correlations of plasma neurodegenerative proteins and electroencephalography (EEG) dynamic functional network (DFN) parameters with disease progression in early Parkinson’s disease (PD) with different motor subtypes, including tremor-dominant (TD) and postural instability and gait disorder (PIGD).MethodsIn our study, 33 patients with PD (21 TD and 12 PIGD) and 33 healthy controls (HCs) were enrolled. Plasma neurofilament light chain (NfL), α-synuclein (α-syn), total-tau (t-tau), β-amyloid 42 (Aβ42), and β-amyloid 40 (Aβ40) levels were measured using an ultrasensitive single-molecule array (Simoa) immunoassay. All the patients with PD underwent EEG quantified by DFN analysis. The motor and non-motor performances were evaluated by a series of clinical assessments. Subsequently, a correlation analysis of plasma biomarkers and EEG measures with clinical scales was conducted.ResultsIn the TD group, plasma NfL exhibited a significant association with MDS-UPDRS III and Montreal Cognitive Assessment (MoCA). A higher Aβ42/40 level was significantly related to a decrease in Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) in the PIGD group. In terms of the correlation between EEG characteristic parameters and clinical outcomes, trapping time (TT) delta was positively correlated with MDS-UPDRS III and MoCA scores in the TD group, especially in the prefrontal and frontal regions. For other non-motor symptoms, there were significant direct associations of kPLI theta with HAMD and HAMA, especially in the prefrontal region, and kPLI gamma was particularly correlated with Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ) scores in the prefrontal, frontal, and parietal regions in the TD group. Furthermore, there was a significant positive correlation between plasma t-tau and kPLI, and pairwise correlations were found among plasma NfL, theta TT, and MoCA scores in the TD group.ConclusionThese results provide evidence that plasma neurodegenerative proteins and EEG measures have great potential in predicting the disease progression of PD subtypes, especially for the TD subtype. A combination of these two kinds of markers may have a superposition effect on monitoring and estimating the prognosis of PD subtypes and deserves further research in larger, follow-up PD cohorts.
Intra-Arterial Thrombolysis Vs. Mechanical Thrombectomy in Acute Minor Ischemic Stroke Due to Large Vessel Occlusion
Authors: Sun Dapeng , Huo Xiaochuan , Raynald  , Wang Anxin , Mo Dapeng , Gao Feng , Ma Ning , Miao Zhongrong 
Published: July 2022

BackgroundThe efficacy and safety of mechanical thrombectomy (MT) in acute large vessel occlusion (LVO) patients with minor stroke (NIHSS ≤ 5) remains undetermined. We aimed to compare the efficacy and safety of intra-arterial thrombolysis (IAT) alone vs. MT for LVO patients with minor stroke.MethodsPatients were selected from the Acute Ischemic Stroke Cooperation Group of Endovascular Treatment (ANGEL) registry, a prospective multicenter registry study, and divided into MT and IAT alone groups. We compared the outcome measures between the two groups, including 90-day functional outcome evaluated by the modified Rankin Scale (mRS), the final recanalization level, intracranial hemorrhage, and mortality within 90-days by logistic regression models with adjustment. Besides the conventional multivariable analysis, we performed a sensitivity analysis by adjusting the propensity score to confirm our results. The propensity score was derived using a logistic regression model.ResultsOf the 120 patients, 63 received IAT alone and 57 received MT as the first-line treatment strategy. As compared to MT group, patients in the IAT alone group were associated with a higher chance of 90-day mRS 0-2 [93.7% vs. 71.9%, odds ratio (OR) = 4.75, 95% confidence interval (CI): 1.20–18.80, P = 0.027], a high chance of 90-day mRS 0-3 (96.8% vs. 86.7%, OR = 11.35, 95% CI: 1.93–66.86, P = 0.007), a shorter median time from puncture to recanalization (PTR) (60 min vs. 100 min, β = −63.70, 95% CI: −81.79– −45.61, P &lt; 0.001), a lower chance of any intracranial hemorrhage (ICH) within 48 h (3.2% vs. 19.3%, OR = 0.15, 95% CI: 0.03–0.79, P = 0.025), and a lower chance of mortablity within 90 days (1.6% vs. 9.2%, OR = 0.05, 95% CI: 0.01–0.57, P = 0.016). Similarly, the sensitivity analysis showed the robustness of the primary analysis.ConclusionsCompared with MT, IAT may improve 90-day clinical outcomes with decreased ICH rate and mortality in LVO patients with minor stroke.
Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage
Authors: Wang Gang , Zhao Wenjun , Zhao Zhiyong , Wang Dengfeng , Wang Dong , Bai Ruobing , Hou Boru , Ren Haijun 
Published: July 2022

ObjectiveDue to the interaction of leukocytes with platelets and coagulation factors, they may in turn play a role in hemostasis or the formation of thrombi. This study aimed to investigate the association of leukocytosis on admission with an increased risk of acute lower-extremity deep venous thrombosis (LEDVT) in elderly patients with primary intracerebral hemorrhage (ICH).MethodsThis was a single-center, retrospective observational study of consecutive patients observed with spontaneous ICH aged 60 years or above at Lanzhou University Second Hospital from January 2017 to September 2021. Clinical data and demographic information were collected and analyzed. Univariate and multivariate analyses were conducted to identify independent risk factors of acute LEDVT. One-to-one matching was implemented to balance important patient characteristics by the groups' propensity score matching (PSM) analysis.ResultsA total of 371 elderly patients with primary ICH fulfilled requirements for inclusion and exclusion, of whom 33 (8.89%) experienced LEDVT. Leukocyte counts were statistically higher in the LEDVT group compared to the non-LEDVT group [12.89 (8.80–14.61) × 109 cells/L vs. 8.31 (6.60–10.75) × 109 cells /L, p &lt; 0.001]. Multivariate logistic regression models adjusted for several potential confounding factors were performed, and leukocytes were consistently a significant independent predictor of LEDVT. The optimal cut-off value of leukocyte counts calculated from the receiver operating characteristic (ROC) curve to predict LEDVT was 10.22 × 109 cells /L (area under the curve:0.714, 95%CI 0.665–0.759; the sensitivity was 72.73%; the specificity was 71.01%) in elderly patients with primary ICH. After one-to-one PSM, compared to the matched non-LEDVT group, the matched LEDVT group had significantly higher leukocyte counts [11.98 (8.40–13.94) × 109 cells/L vs. 6.12 (4.68–12.00) × 109 cells/L, p = 0.003]. After PSM, the ROC curve was plotted for leukocytes as a predictor of LEDVT, with an AUC of 0.722 (95%CI 0.593–0.828, p = 0.001; the sensitivity was 87.10%, and the specificity was 61.29%). Elevated leukocytes remained independently significant as predictors of LEDVT in elderly patients with primary ICH.ConclusionLeukocyte at admission is an independent risk factor of LEDVT in elderly patients with primary ICH.
Association Between High Serum Anion Gap and All-Cause Mortality in Non-Traumatic Subarachnoid Hemorrhage: A Retrospective Analysis of the MIMIC-IV Database
Authors: Zhong Changli , Ye Min , Hu Liyi , Liu Jiuling 
Published: July 2022

Background:High serum anion gap (AG) on admission is often correlated with poor outcomes in critically ill patients; however, data in patients with non-traumatic subarachnoid hemorrhage (SAH) are lacking. Herein, we aimed to identify the association between serum AG and all-cause mortality in patients with non-traumatic SAH.MethodsA retrospective analysis of data from the Medical Information Mart for Intensive Care (MIMIC-IV) database was performed on critically ill patients with non-traumatic SAH. Serum AG was collected on Intensive Care Unit (ICU) admission, and ICU and hospital all-cause mortality were analyzed. The multivariate Cox proportional hazard regression model and Kaplan-Meier survival curve analysis were used to analyze the correlation of serum AG with ICU and hospital all-cause mortality. Furthermore, interaction and subgroup analyses were evaluated for the consistency of these correlations.ResultsA total of 893 patients with non-traumatic SAH were included in this study. The all-cause mortality in ICU and hospital were 14.8% (132/893), and 18.9% (169/893), respectively. Multivariate analysis after adjusting for potential confounders indicated that high serum AG levels (≥16 mmol/L) were associated with increased risk of ICU and hospital all-cause mortality as compared to that with low serum AG levels (&lt;16mmol/L), (hazards ratio (HR): 2.31 [95% CI: 1.58–3.38]) and HR: 1.91 [95% CI: 1.36–2.67)], respectively). Similarly, the Kaplan–Meier (K–M) survival curve also showed that patients with high serum AG levels presented with a lower survival rate. Stratified analyses further showed that depending on the variable testes, an association between higher serum AG levels and hospital all-cause mortality in different subgroups was observed.ConclusionAmong patients with non-traumatic SAH, high serum AG level at ICU admission was associated with increased ICU and hospital all-cause mortality.
Objective Observer vs. Patient Motor State Assessments Using the PD Home Diary in Advanced Parkinson's Disease
Authors: Timpka Jonathan , Löhle Matthias , Bremer Alexander , Christiansson Sofia , Gandor Florin , Ebersbach Georg , Dahlström Örjan , Iwarsson Susanne , Nilsson Maria H. , Storch Alexander , Odin Per 
Published: July 2022

BackgroundThe Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers.ObjectiveValidation of patient-reported HD by investigating the agreement between motor state assessments by patients and observers.MethodsThis observational study included patients with PD and motor fluctuations. Observers were physicians or research nurses. Patients completed a screening visit, one day of diary ratings at home, and then two days of ratings on-site during which patients and observers simultaneously judged the participants' motor state.ResultsObservers and 40 patients completed 1,288 pairs of half-hourly blinded motor state assessments. There were significant differences between observer and patient ratings (P &lt; 0.001) and the temporal agreement was poor (Cohen's κ = 0.358). The agreement between patient and observer ratings was 71.1% for observed “On without dyskinesia”, 57.3% for observed “Off”, and 49.4% for observed “On with dyskinesia”. Daily times spent in the three motor states as aggregated diary data showed fair to excellent reliability with intraclass coefficient values ranging from 0.45 to 0.52 for “On” and 0.77 for “Off”.ConclusionThere were significant differences between observer and patient ratings. Patients and observers generally agreed on when the patients was in the “On” state (with or without dyskinesia). Patient ratings on the hour level seem to be influenced by other aspects of the patients' experience than the observed motor state, but assessment of daily time spent in the different motor state provides reasonable reliability.