bluuebunny/crossref_metadata_2025_split huggingface dataset:
Just Drink a Glass of Water? Effects of Bicarbonate–Sulfate–Calcium–Magnesium Water on the Gut–Liver Axis
Authors: Gravina Antonietta Gerarda , Romeo Mario , Pellegrino Raffaele , Tuccillo Concetta , Federico Alessandro , Loguercio Carmelina 
Published: June 2022

Background and Aim: Fonte Essenziale® water is a bicarbonate–sulfate–calcium–magnesium water, low in sodium, recognized by the Italian health care system in hydropinotherapy and hepatobiliary dyspepsia therapy. We wanted to explore its effects on the gut–liver axis and microbiota in non-alcoholic fatty liver disease patients.Patients and Methods: We considered enrollment for 70 patients, of which four were excluded. We finally enrolled 55 patients with ultrasound-documented steatosis (SPs+) and 11 patients without it (SPs−). They then drank 400 ml of water for 6 months in the morning on an empty stomach. Routine hematochemical and metabolic parameters, oxidative stress parameters, gastrointestinal hormone levels, and fecal parameters of the gut microbiota were evaluated at three different assessment times, at baseline (T0), after 6 months (T6), and after a further 6 months of water washout (T12). We lost, in follow-up, 4 (T6) and 22 (T12) patients.Results: Between T0–T6, we observed a significant Futuin A and Selenoprotein A decrease and a GLP-1 and PYY increase in SPs+ and the same for Futuin A and GLP-1 in SPs−. Effects were lost at T12. In SPs+, between T0–T12 and T6–12, a significant reduction in Blautia was observed; between T0–T12, a reduction of Collinsella unc. was observed; and between T0–T12 and T6–12, an increase in Subdoligranulum and Dorea was observed. None of the bacterial strains we analyzed varied significantly in the SPs− population.Conclusion: These results indicate beneficial effects of water on gastrointestinal hormones and hence on the gut–liver axis in the period in which subjects drank water both in SPs− and in SPs+.
Psychological Distress Among Infertility Patients: A Network Analysis
Authors: Cao Danfeng , Bai Caifeng , Zhang Guoxiang 
Published: June 2022

BackgroundPsychological distress is common among infertility patients. Total scale scores are often used to represent the severity of anxiety, depression, or stress, which ignores important differences between specific symptoms, and relationships between symptoms. This study aimed to identify patterns of psychological distress experienced by infertility patients and to identify the most central symptoms of anxiety, depression, and stress.MethodFrom June to September 2016, 740 infertility patients were included in this cross-sectional study. Infertility patients were asked to complete the Generalized Anxiety Disorder-7, Patients Health Questionnaire-9 (PHQ-9), and Fertility Problem Inventory. Network analysis was used to examine the patterns of psychological distress in infertility patients and to test the most central symptoms of anxiety, depression, and stress.ResultsRestlessness was the most central symptom in infertility patients. “Feelings of guilt” had the highest strength among PHQ-9 symptoms. “Relationship concern stress” and “sexual concern stress” had the strongest connections in the network. Stability estimation indicated that the order of node strength centrality was more stable than the order of closeness and betweenness (the CS-coefficients were 0.75, 0.13, and 0.67, respectively). In addition, network structure and global strength were invariant across gender.LimitationsThe cross-sectional design did not permit identification of causal relationships. Patients in this study were recruited from one reproductive hospital; especially, most patients had low socioeconomic status, which limits generalizability of the findings.ConclusionThis study reinforces the need to better understand the underlying causes of psychological distress in infertile patients. A more detailed investigation of the relationship between these symptoms could provide information for psychosocial interventions aimed beyond “alleviating psychological distress.” We should consider the individual psychological symptom pattern and its potential causes in infertility patients instead of assuming a consistent psychological distress structure.
Dysregulated Methylation Patterns in Exon IV of the Brain-Derived Neurotrophic Factor (BDNF) Gene in Nicotine Dependence and Changes in BDNF Plasma Levels During Smoking Cessation
Authors: Abdelkhalek Kerim , Rhein Mathias , Deest Maximilian , Buchholz Vanessa , Bleich Stefan , Lichtinghagen Ralf , Vyssoki Benjamin , Frieling Helge , Muschler Marc , Proskynitopoulos Phileas Johannes , Glahn Alexander 
Published: June 2022

IntroductionSeveral studies reported dysregulated protein levels of brain-derived neurotrophic factor (BDNF) in smokers and during cessation. However, the epigenetic regulation of the BDNF gene has not yet been investigated. We measured the plasma levels of BDNF and the epigenetic regulation of exon IV of the BDNF gene in smokers compared to healthy controls over a cessation period of 14 days.MethodWe measured BDNF plasma levels and BDNF promoter methylation in 49 smokers and 51 non-smokers at baseline, day 7, and day 14 of smoking cessation. Mean methylation levels of 11 Cytosine Guanosine dinucleotides of exon IV of the BDNF gene were determined via bisulfite sequencing.ResultsBDNF plasma and methylation levels were significantly lower in healthy controls when compared with smokers across all time points. BDNF levels for smokers decreased significantly during the cessation period. Comparing the sexes, female smokers showed significantly lower plasma BDNF levels than healthy controls at baseline and over 14 days of cessation. Male and female smokers showed significantly higher mean methylation rates than non-smokers at baseline. In male smokers, mean methylation levels decreased significantly during the cessation period.ConclusionOur findings replicate the findings of previous studies that BDNF plasma levels are altered in smokers. Furthermore, BDNF expression and gene methylation are altered during the first 14 days of cessation. Our novel findings of dysregulated methylation patterns in exon IV of the BDNF gene further support the thesis that BDNF plays a role in nicotine dependence.
Medium Spatial Resolution Mapping of Global Land Cover and Land Cover Change Across Multiple Decades From Landsat
Authors: Friedl Mark A. , Woodcock Curtis E. , Olofsson Pontus , Zhu Zhe , Loveland Tom , Stanimirova Radost , Arevalo Paulo , Bullock Eric , Hu Kai-Ting , Zhang Yingtong , Turlej Konrad , Tarrio Katelyn , McAvoy Kristina , Gorelick Noel , Wang Jonathan A. , Barber Christopher P. , Souza Carlos 
Published: June 2022

Land cover maps are essential for characterizing the biophysical properties of the Earth’s land areas. Because land cover information synthesizes a rich array of information related to both the ecological condition of land areas and their exploitation by humans, they are widely used for basic and applied research that requires information related to land surface properties (e.g., terrestrial carbon models, water balance models, weather, and climate models) and are core inputs to models and analyses used by natural resource scientists and land managers. As the Earth’s global population has grown over the last several decades rates of land cover change have increased dramatically, with enormous impacts on ecosystem services (e.g., biodiversity, water supply, carbon sequestration, etc.). Hence, accurate information related to land cover is essential for both managing natural resources and for understanding society’s ecological, biophysical, and resource management footprint. To address the need for high-quality land cover information we are using the global record of Landsat observations to compile annual maps of global land cover from 2001 to 2020 at 30 m spatial resolution. To create these maps we use features derived from time series of Landsat imagery in combination with ancillary geospatial data and a large database of training sites to classify land cover at annual time step. The algorithm that we apply uses temporal segmentation to identify periods with stable land cover that are separated by breakpoints in the time series. Here we provide an overview of the methods and data sets we are using to create global maps of land cover. We describe the algorithms used to create these maps and the core land cover data sets that we are creating through this effort, and we summarize our approach to accuracy assessment. We also present a synthesis of early results and discuss the strengths and weaknesses of our early map products and the challenges that we have encountered in creating global land cover data sets from Landsat. Initial accuracy assessment for North America shows good overall accuracy (77.0 ± 2.0% correctly classified) and 79.8% agreement with the European Space Agency (ESA) WorldCover product. The land cover mapping results we report provide the foundation for robust, repeatable, and accurate mapping of global land cover and land cover change across multiple decades at 30 m spatial resolution from Landsat.
Robust Identification of the QRS-Complexes in Electrocardiogram Signals Using Ramanujan Filter Bank-Based Periodicity Estimation Technique
Authors: Mukhopadhyay Sourav Kumar , Krishnan Sridhar 
Published: June 2022

Plausibly, the first computerized and automated electrocardiogram (ECG) signal processing algorithm was published in the literature in 1961, and since then, the number of algorithms that have been developed to-date for the detection of the QRS-complexes in ECG signals is countless. Both the digital signal processing and artificial intelligence-based techniques have been tested rigorously in many applications to achieve a high accuracy of the detection of the QRS-complexes in ECG signals. However, since the ECG signals are quasi-periodic in nature, a periodicity analysis-based technique would be an apt approach for the detection its QRS-complexes. Ramanujan filter bank (RFB)-based periodicity estimation technique is used in this research for the identification of the QRS-complexes in ECG signals. An added advantage of the proposed algorithm is that, at the instant of detection of a QRS-complex the algorithm can efficiently indicate whether it is a normal or a premature ventricular contraction or an atrial premature contraction QRS-complex. First, the ECG signal is preprocessed using Butterworth low and highpass filters followed by amplitude normalization. The normalized signal is then passed through a set of Ramanujan filters. Filtered signals from all the filters in the bank are then summed up to obtain a holistic time-domain representation of the ECG signal. Next, a Gaussian-weighted moving average filter is used to smooth the time-period-estimation data. Finally, the QRS-complexes are detected from the smoothed data using a peak-detection-based technique, and the abnormal ones are identified using a period thresholding-based technique. Performance of the proposed algorithm is tested on nine ECG databases (totaling a duration of 48.91 days) and is found to be highly competent compared to that of the state-of-the-art algorithms. To the best of our knowledge, such an RFB-based QRS-complex detection algorithm is reported here for the first time. The proposed algorithm can be adapted for the detection of other ECG waves, and also for the processing of other biomedical signals which exhibit periodic or quasi-periodic nature.
Detection and Quantification of ctDNA for Longitudinal Monitoring of Treatment in Non-Small Cell Lung Cancer Patients Using a Universal Mutant Detection Assay by Denaturing Capillary Electrophoresis
Authors: Benesova Lucie , Ptackova Renata , Halkova Tereza , Semyakina Anastasiya , Svaton Martin , Fiala Ondrej , Pesek Milos , Minarik Marek 
Published: June 2022

Background: Observation of anticancer therapy effect by monitoring of minimal residual disease (MRD) is becoming an important tool in management of non-small cell lung cancer (NSCLC). The approach is based on periodic detection and quantification of tumor-specific somatic DNA mutation in circulating tumor DNA (ctDNA) extracted from patient plasma. For such repetitive testing, complex liquid-biopsy techniques relying on ultra-deep NGS sequencing are impractical. There are other, cost-effective, methods for ctDNA analysis, typically based on quantitative PCR or digital PCR, which are applicable for detecting specific individual mutations in hotspots. While such methods are routinely used in NSCLC therapy prediction, however, extension to cover broader spectrum of mutations (e.g., in tumor suppressor genes) is required for universal longitudinal MRD monitoring.Methods: For a set of tissue samples from 81 NSCLC patients we have applied a denaturing capillary electrophoresis (DCE) for initial detection of somatic mutations within 8 predesigned PCR amplicons covering oncogenes and tumor suppressor genes. Mutation-negative samples were then subjected to a large panel NGS sequencing. For each patient mutation found in tissue was then traced over time in ctDNA by DCE.Results: In total we have detected a somatic mutation in tissue of 63 patients. For those we have then prospectively analyzed ctDNA from collected plasma samples over a period of up to 2 years. The dynamics of ctDNA during the initial chemotherapy therapy cycles as well as in the long-term follow-up matched the clinically observed response.Conclusion: Detection and quantification of tumor-specific mutations in ctDNA represents a viable complement to MRD monitoring during therapy of NSCLC patients. The presented approach relying on initial tissue mutation detection by DCE combined with NGS and a subsequent ctDNA mutation testing by DCE only represents a cost-effective approach for its routine implementation.
Erector spinae plane block vs. single shot epidural block for postoperative analgesia in lumbar spine surgery: a randomized controlled trial
Authors: Abdelhamid Hebatallah Salah , ElSabbagh Hala Ahmed , Amin Shereen Mostafa , Abdelhakeem Amr K. 
Published: June 2022

Background: Epidural block is an effective route for analgesia in spine surgeries. Erector spinae plane block (ESPB) is a field block that showed promising results in various surgeries. We compared both procedures in spine surgery, regarding postoperative pain, the time to first analgesic request, postoperative total morphine consumption, perioperative hemodynamics, and any adverse events.
Methodology: Sixty-seven patients were enrolled in this double-blinded randomized controlled study. Patients were allocated into two groups. The epidural group received an ultrasound-guided single-shot epidural block with 20 mL of 0.25% bupivacaine. The ESPB group received an ultrasound-guided bilateral single-shot ESPB with 20 mL of 0.25% bupivacaine for each side. Postoperative pain, the time to first analgesic request, postoperative total morphine consumption, perioperative hemodynamics, and any adverse events were recorded.
Results: The time to the first analgesic requirement was longer in the ESPB group (11.5 [9-14] h, vs. 7 [5-8] h, P < 0.001). The mean morphine consumption was lower in the ESPB group (3.88 ± 0.54 vs. 7.12 ± 1.94 mg; P < 0.001). The numeric rating scale was lower in the epidural group. Less patients experienced intraoperative hypotension and tachycardia in ESPB group.
Conclusion: ESPB provides longer postoperative analgesia, less opioid consumption, and more intraoperative hemodynamic stability when compared with a single-shot epidural block in lumbar spine surgery.
Trial registration: The ethical approval was obtained from the Research Ethics Committee of Cairo University (M D-82-2019), and the trial was registered on www.clinicaltrials.gov with registration number (NCT04320212). https://clinicaltrials.gov/ct2/show/NCT04320212
Abbreviations: ESPB - Erector spinae plane block; LA - Local anesthetics
Key words: Erector spinae plane block; Pain, Postoperative; Spine surgery; Analgesia, Epidural; Fascial plane blocks; Neuraxial analgesia
Citation: Abdelhamid HS, ElSabbagh HA, Amin SM, Abdelhakim AK. Erector spinae plane block vs. single shot epidural block for postoperative analgesia in lumbar spine surgery: a randomized controlled trial. Anaesth. pain intensive care 2022;26(3):310-317.
DOI: 10.35975/apic.v26i3.1897
Received: February 01, 2022; Reviewed: March 13, 2022; Accepted: March 23, 2022
Başlangıçtan Günümüze Çin Dış Politikasının Dönüşümü: Büyük Ülke Diplomasisi
Authors: KEYVAN Özlem Zerrin 
Published: June 2022

Xi Jinping’in 2012’de iktidara gelmesiyle, Çin dış politikasında büyük değişimler ortaya çıkmıştır. Xi, Deng Xiaoping›in düşük profilli kalma doktrinini, başarı için çabalayan daha iddialı diplomatik stratejisiyle değiştirmiştir. Ancak Çin, kapsayıcı barışçıl kalkınma stratejisinden asla vazgeçmemiştir. Aynı zamanda Xi Jinping yönetiminde Çin, dış politikanın markası olarak “Çin Karakterli Büyük Ülke Diplomasisini” formüle etmiştir. Xi ayrıca, Çin ulusunun büyük gençleşmesinin bir parçası olarak Çin rüyasını ve insanlık için ortak bir geleceğin parçası olarak Dünya rüyasını benimsemiştir. Bu çalışmanın amacı Mao Zedong, Deng Xiaoping ve Xi Jinping’in diplomatik stratejilerinin teori ve pratiğini araştırmak ve bunların dönemselleştirilmesine ve içeriğine ilişkin Çin görüşünü sistematize etmek olmuştur. Böylece bu çalışma Xi’nin büyük ülke diplomasisini stratejik ortaklıklar, kapsayıcı bir kalkınma modeli olarak Kuşak ve Yol girişimi ve deniz milliyetçiliği ışığında incelemektedir.
PERBEDAAN PENGARUH LATIHAN SHOOTING MENGGUNAKAN PENGHALANG DAN TANPA PENGHALANG TERHADAP PENINGKATAN SHOOTING JARAK 7 METER PADA ATLET PETANQUE KABUPATEN SRAGEN
Authors: Mayangsari Christin , Supriyoko Agus , Karisma sari Yudi 
Published: June 2022

ABSTRAK
Tujuan dari penelitian ini adalah : (1) Untuk mengetahui pengaruh latihan shooting menggunakan penghalang dan tanpa menggunkan penghalang terhadap peningkatan shooting jarak 7 meter. (2) Untuk mengetahui hasil efektifitas latihan shooting menggunakan penghalang dan tanpa mrnggunakan penghalang terhadap peningkatan shooting jarak 7 meter.
Populasi dalam penelitian ini adalah atlet petanque Kabupaten Sragen yang berjumlah 20 atlet. Penelitian yang digunakan adalah penelitian eksperimen dengan jumlah sample 20 atlet dengan metode “One Groups Pre-test Post-test Design”, yaitu model penelitian yang terdapat pre-test sebelum di beri perlakuan dan post-test setelah diberikan perlakuan. Serta di bagi 2 kelompok dalam eksperimen tersebut (matched subject design). Kemudian diberikan perlakuan (treatment) sebelum mengambil data post-test.
Berdasarkan analisis data, untuk hasil latihan shooting menggunakan penghalang menghasilkan data pre-test dengan rata-rata = 3,5 dan SB = 2,539 dengan skor tertinggi 8 dan terendah 0, untuk data post-test yaitu dengan rata-rata =11,4 dan SB= 3,469, dengan skor tertinggi 16 dan terendah 7. Untuk hasil latihan shooting tanpa penghalang menghasilkan data pre-test dengan rata-rata = 4,4 dan SB= 1,907, dengan skor tertinggi 8 dan terendah 2, untuk data post-test yaitu dengan rata-rata sebesar = 9,5 dan SB= 3,008, dengan skor tertinggi 15 dan terendah 6. Hasil uji reliabilitas pre-test rxy= 0,734. Hasil uji normalitas kelompok A Lhitung= 0,17408 < Ltabel= 0,258, untuk kelompok B Lhitung= 0,18272 < Ltabel= 0,258, dengan taraf signifikan 5%. Hasil uji homogenitas Fhitung= 1,331 < Ftabel= 3,18 dengan taraf siginifikan 5%. Hasil uji t pre-test thitung= 2,3777 < ttabel= 1,8331, uji t kelompok A thitung= 11,1847 < ttabel= 1,8331, uji t kelompok B thitung= 3,1929 < ttabel= 1,8331, uji t post-test kelompok A dan B thitung= 2,3097 < ttabel= 1,8331 dengan taraf signifikasi 5%. Presentase hasil peningkatan kelompok A sebesar= 60,7%, dan kelompok B sebesar= 39,2%.
Kata kunci : Petanque, shooting, penghalang, tanpa penghalang
PELATIHAN KONSELING KELUARGA BERENCANA (KB) PADA KADER KB DI KABUPATEN SRAGEN
Authors: Prasasti Suci , Haryanti Usmani 
Published: June 2022

ABSTRAK :
Keberadaan konseling dalam layanan KB sangat diperlukan dan merupakan media dari PKB dalam mensosialisikan program KB. Berhasil tidaknya layanan KB tergantung dari konseling yang dilakukan oleh Penyuluh KB terhadap masyarakat sehingga diharapakan semua Penyuluh KB yang tersebar di daerah (desa) dapat melakukan konseling dengan baik sesuai dengan prosedur dan ketrampilan konseling. Berkaiatan dengan pentingnya konseling bagi PKB, maka diperlukan suatu bentuk pelathan yang berkaitan dengan konseling yang didasari pada kebutuhan alat kontrasespsi bagi masyarakat dan sosialisasi program KB.
PENINGKATAN PUKULAN SMASH ATLET BULUTANGKIS UTP SURAKARTA
Authors: Muchhamad Sholeh  
Published: June 2022

ABSTRAK
Kegiatan pengabdian ini dilaksanakan pada bulan Desember 2021 – Januari 2022, Pukul 15.00-17.00 wib bertempat di Dojo Jatisrono. Peserta berjumlah 25 atlet. Peserta sangat antusias untuk mengikuti materi pelatihan. Sebelum praktek diberikan, secara singkat peserta diberikan materi tentang sejarah perkembangan olahraga bulutangkis yang sudah sangat bermasyarakat, selain itu teknik bulutangkis dan latihan Komponen fisik bulutangkis dapat meningkat dengan signifikan. Metode yang digunakan adalah dengan bentuk kegiatan dalam pelatihan olahraga bulutangkis ini dengan menggunakan pendekatan langsung, demontrasi, diskusi, praktek dan evaluasi terhadap serapan dari atlet yang ikut langsung di lokasi yaitu di aula FKIP UTP Surakarta, metode latihan memiliki efektifitas yang berbeda dalam peningkatan hasil belajar Ketepatan Smash dalam olahraga bulutangkis pada Atlet Bulutangkis UTP Surakarta. Oleh karena itu, dalam menerapkan metode latihan yang bertujuan untuk mengembangkan atau peningkatan hasil Ketepatan Smash dalam olahraga bulutangkis harus menggunakan metode latihan yang tepat dan sesuai dengan keadaan atlet. Hasil penelitian ini juga dapat dijadikan sebagai bahan pertimbangan dalam memilih dan menentukan metode latihan yang tepat, khususnya untuk peningkatan hasil Ketepatan Smash.
ANALISIS KRITIS TERKAIT EFEKTIVITAS PROGRAM PELATIHAN DAN PRODUKTIVITAS TENAGA KERJA DALAM MENGURANGI ANGKA PENGANGGURAN OLEH DINAS TENAGA KERJA KOTA CIMAHI PADA MASA COVID-19 TAHUN 2021
Authors: Antika Galuh Ageng , Kurnia Dadan , Munawaroh Siti 
Published: June 2022

Pengangguran ialah masalah perekonomian yang cukup rumit dan selalu muncul dari tahun ke tahun diberbagai daerah di Indonesia salah satunya kota cimahi yang berada di provinsi Jawa Barat. Pengangguran yang terjadi di Kota Cimahi diakibatkan oleh beberapa faktor yaitu kepadatan penduduk yang setiap tahunnya meningkat, adanya pandemi Covid-19 dan ketidakseimbangan antara pencari kerja dengan lapangan pekerjaan yang tersedia. Tujuan penelitian ini tentang analisis kritis terkait efektivitas program pelatihan dan produktivitas tenaga kerja dengan menggunakan teori efektivitas program dengan indikator ketetapan sasaran program, sosialisasi program, tujuan program, dan pemantauan program. Cara pengumpulan data yang dilakukan seperti observasi, wawancara, dan dokumentasi. Hasil penelitian berdasarkan empat indikator dari efektivitas program sudah berjalan dengan baik, ditunjukan dengan turunnya presentase angka pengangguran dari 13,30% menjadi 13,07%. dimana tujuan dari pelatihan adalah memberikan bekal kepada masyarakat Kota Cimahi untuk mampu bekerja dan membuka lapangan usaha sendiri. Dinas Tenaga Kerja Kota Cimahi sudah memaksimalkan dengan sebaik mungkin dalam mengurangi angka pengangguran di Kota Cimahi dengan menyelenggarakan program pelatihan dan produktivitas tenaga kerja, dan program pelatihan kerja ini secara umum sudah bekerja dengan efektif.
Kata Kunci: Dinas Tenaga Kerja, Pelatihan Tenaga Kerja, Pengangguran