bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D toxicity – causes, symptoms and diagnosis
Authors: Kosz Katarzyna , Remjasz Klaudia , Kuchnicka Aleksandra , Kuchnicka Julia , Zarankiewicz Natalia , Zielińska Martyna , Sapuła Klaudia , Aleksandrowicz Jakub , Siedlecki Wojciech 
Published: August 2022

Abstract:
Introduction and purpose: This review aims to analyze causes, symptoms and diagnosis of overdosing vitamin D resulting in vitamin D toxicity (VDT).
Material and method: This paper was based on medical articles collected in Pubmed from 2008 to 2021 year. The research has been done by looking through keywords such as “vitamin D” “toxicity”.
Results: The review of studies showed that manifestation of VDT is mainly associated with hypercalcemia and its course can range from asymptomatic to life-threatening, including death. We also draw attention to inappropriate use and widespread of vitamin D products.
Conclusion: There is a high demand for medical health workers to advise patients on possible effects of inappropriate use of vitamin D products and its toxicity. Medical practitioners should be attentive to quickly identify VDT.
Dietary self-care and associated factors among diabetic patients in Jimma University Medical Centre, South West Ethiopia; A path analysis
Authors: Jemal Musa , Argaw Alemayehu , Taye Abonesh , Sintayehu Tsion , Kedir Shemsu 
Published: August 2022

Background
Diabetes Mellitus (DM), a chronic metabolic disorder that caused about 4.2 million deaths and at least 760 billion dollars’ expenditure in 2019, has been targeted for action by leaders of WHO member countries. In Ethiopia deaths, due to DM reached 34,262 in 2013. Studies show effective lifestyle interventions; particularly medical nutrition therapy reduces HbA1c by 0.5 to 2%. However, practicing recommended diet is reported to be difficult. Not only Knowledge and practice but also perception studies are therefore necessary to design future health programs.

Objective
To assess diabetic self-care, dietary practice and associated factors among diabetes patients.

Method
Institution-basedbased cross-sectional study design was employed from february15-May15, 2020 in Jimma university medical Centre (JUMC). Systematic sampling of every other patient (K = 2.7) was employed to interview 371 participants. A previously validated tool was used to collect data through a face-to-face interview. A path analysis was used to fit the structural model and tests the hypothesized Health Belief Model (HBM) relationships.

Result
Response rate was 95.4% (354). Around 52% of the participants were male and 76.8% follow diabetic education at least some times. 42.4% and 48% of respondents have good dietary and general self-care practices respectively. With unstandardized coefficient (standard error) self-efficacy0.10 (0.01) being the strongest cues to action0.10 (0.02), perceived threat0.02 (0.01), and perceived barrier-0.08(0.01) constructs of HBM have a significant effect on dietary practice. Knowledge, social support and diabetes distress exert a significant indirect effect on dietary practice through health belief constructs with unstandardized path coefficient (standard error) of 0.22(0.03), 0.02(0.01), and -0.03(0.004) respectively.

Conclusion
In this study, the proportion of good practice is found to be lower for both dietary as well as general self-care. HBM can best fit to explain variability in dietary self-care practice; therefore, future interventions should be designed to address the vast perception and psychosocial factors influencing dietary self-care practices.
Corrosion behaviour OF HVOF deposited Zn–Ni–Cu and Zn–Ni–Cu–TiB2 coatings on mild steel
Authors: Ali Sheikh Idrees , Ahmad Sheikh Nazir 
Published: August 2022

Abstract
In this study, Zn–Ni–Cu and Zn–Ni–Cu–TiB2 coatings were deposited using high-velocity oxy-fuel (HVOF) thermal spray technique on a mild steel substrate. Corrosion tests like neutral salt spray (NSS) following (ASTM B-117) standard and immersion cycle test following ASTM G-31, ASTM G1-03, standards were carried out for Zn–Ni–Cu and Zn–Ni–Cu–TiB2 coated mild steel along with uncoated mild steel acting as a control. Both Zn–Ni–Cu and Zn–Ni–Cu–TiB2 coated mild steel were corrosion resistant as compared to uncoated mild steel. Raman analysis following the immersion cycle test inferred that uncoated mild steel had all forms of rust. While Zn–Ni–Cu and Zn–Ni–Cu–TiB2 coated mild steel developed very little rust. The characterization helped to understand the changes in the surface before and after tests. It was observed that both Zn–Ni–Cu and Zn–Ni–Cu–TiB2 coated mild steel had little corrosion degradation of surface as compared to uncoated mild steel. Suggesting that both coatings performed significantly better compared to uncoated mild steel in corrosive environments. Polarization and EIS tests of both coated and uncoated mild steel in a 3.5% NaCl medium helped to understand the behaviour of coatings over a range of frequencies. Both coated samples had high polarization potential E
corr values and lower polarization current I
corr values as compared to uncoated mild steel. Inferring better performance of coatings in corrosive environments as compared to uncoated mild steel.
The (2, 3)-generation of the finite 8-dimensional orthogonal groups
Authors: Pellegrini Marco Antonio , Tamburini Bellani Maria Chiara 
Published: August 2022

Abstract
We construct

(
2
,
3
)

(2,3)

-generators for the finite 8-dimensional orthogonal groups, proving the following results: the groups

Ω
8
+

⁢

(
q
)

\Omega_{8}^{+}(q)

and

P
⁢

Ω
8
+

⁢

(
q
)

\mathrm{P}\Omega_{8}^{+}(q)

are

(
2
,
3
)

(2,3)

-generated if and only if

q
≥
4

q\geq 4

; the groups

Ω
8
-

⁢

(
q
)

\Omega_{8}^{-}(q)

and

P
⁢

Ω
8
-

⁢

(
q
)

\mathrm{P}\Omega_{8}^{-}(q)

are

(
2
,
3
)

(2,3)

-generated for all

q
≥
2

q\geq 2

.
Crystal structure of (bis(1,10-phenanthroline-κ
2
N,N′))-(3,5-dinitrosalicylato-κ
2
O,O′)nickel(II), C31H18N6NiO7
Authors: Tang Zhiwei , Wu Dewu , Wen Decai 
Published: August 2022

Abstract
C31H18N6NiO7, monoclinic, P21/c (no. 14), a = 7.6619(15) Å, b = 18.470(4) Å, c = 19.113(4) Å, β = 90.53(3)°, V = 2704.6(9) Å3, Z = 4, R
gt(F) = 0.0608, wR
ref(F
2) = 0.1656, T = 293 K.
Impacts of long noncoding RNA MALAT1 on LPS-induced periodontitis via modulating miR-155/SIRT1 axis
Authors: Hu Wanjun , Lei Xiubing , Luo Jianglong , Gou Xing 
Published: August 2022

Abstract

Objectives
Periodontitis, a dental disease that causes inflammation of gums is triggered by a bacterial infection. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) has been reported to participate in inflammatory diseases. In the present study, we investigated the effects of lncRNA MALAT1 on periodontal ligament cells (PDLCs) with lipopolysaccharide (LPS) induction.

Methods
MALAT1, microRNA-155 (miR-155), Sirtuin 1 (SIRT1), Bax, and Bcl-2 RNA expressions were detected by using real-time quantitative polymerase chain reaction (RT-qPCR). PDLC viability and apoptosis were assessed by using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium salt (MTT) assay and flow cytometry. Enzyme-linked immunosorbent assay (ELISA) assessed secretions of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Luciferase reporter test was applied for confirming the binding of miR-155 with MALAT1 and SIRT1, respectively.

Results
Overexpression of MALAT1 facilitated the LPS-induced periodontitis while MALAT1 suppression restrained LPS-induced injury. Also, miR-155 was expressed in LPS-induced PDLCs. Moreover, MALAT1 negatively regulated miR-155 followed by the up-regulation of SIRT1 which in turn reduced the inflammation in LPS-induced PDLCs.

Conclusions
We concluded that upregulated lncRNA MALAT1 could accelerate periodontitis through the regulation of miR-155/SIRT1. Our findings suggested a novel MALAT1/miR-155/SIRT1 pathway for the treatment of periodontitis.
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike
Authors: Cantoni Diego , Murray Matthew J , Kalemera Mphatso D , Dicken Samuel J , Stejskal Lenka , Brown Georgina , Lytras Spyros , Coey Jonathon D , McKenna James , Bridgett Stephen , Simpson David , Fairley Derek , Thorne Lucy G , Reuschl Ann‐Kathrin , Forrest Calum , Ganeshalingham Maaroothen , Muir Luke , Palor Machaela , Jarvis Lisa , Willett Brian , Power Ultan F , McCoy Laura E , Jolly Clare , Towers Greg J , Doores Katie J , Robertson David L , Shepherd Adrian J , Reeves Matthew B , Bamford Connor G G , Grove Joe 
Published: August 2022

AbstractThe emergence of SARS‐CoV‐2 variants has exacerbated the COVID‐19 global health crisis. Thus far, all variants carry mutations in the spike glycoprotein, which is a critical determinant of viral transmission being responsible for attachment, receptor engagement and membrane fusion, and an important target of immunity. Variants frequently bear truncations of flexible loops in the N‐terminal domain (NTD) of spike; the functional importance of these modifications has remained poorly characterised. We demonstrate that NTD deletions are important for efficient entry by the Alpha and Omicron variants and that this correlates with spike stability. Phylogenetic analysis reveals extensive NTD loop length polymorphisms across the sarbecoviruses, setting an evolutionary precedent for loop remodelling. Guided by these analyses, we demonstrate that variations in NTD loop length, alone, are sufficient to modulate virus entry. We propose that variations in NTD loop length act to fine‐tune spike; this may provide a mechanism for SARS‐CoV‐2 to navigate a complex selection landscape encompassing optimisation of essential functionality, immune‐driven antigenic variation and ongoing adaptation to a new host.
Avances en el estudio de la continuidad del neuroticismo y su variante desadaptativa: aplicación de la teoría de respuesta al ítem
Authors: Sanchez Gonzalez Juan Franco , Attorresi Horacio Félix , Abal Facundo Juan Pablo 
Published: August 2022

El Neuroticismo (N), a pesar de ser un rasgo de personalidad normal, se vincula con el padecimiento de diversas psicopatologias. Se estudió la continuidad entre el N y su variante desadaptativa, la Afectividad Negativa (AN), aplicando un modelo de la Teoría de Respuesta al Ítem (TRI) a dos escalas que miden estos constructos. Participaron 619 personas de población general (64.3 % mujeres), quienes respondieron un protocolo que incluyó 20 ítems de N del International Personality Item Pool (IPIP-NEO) y 23 ítems de AN del Personality Inventory for DSM-5 (PID-5). Inicialmenete se realizó una depuración progresiva de los ítems de N y AN a partir de criterios psicométricos del Modelo de Respuesta Graduada. Luego se calibraron conjuntamente los 22 ítems retenidos aunque se eliminaron 6 ítems por mostrar dependencia local y problemas de ajuste. Se aportaron evidencias de la continuidad postulada entre N y AN. Sin embargo, se encontró un marcado solapamiento en la localización de los ítems procedentes de ambas escalas en el continuo del rasgo que conforman N y AN.
Revisión sobre los estudios en el campo académico de la discapacidad y las personas con discapacidad
Authors: Naranjo Tamayo Diana Catalina , Orejuela Gómez Johnny Javier 
Published: August 2022

El propósito de este trabajo es presentar un estado del arte sobre los estudios en el campo académico de la discapacidad en un intento por aportar elementos teóricos a quienes vienen trabajando la discapacidad como problema social y no como un asunto de tipo médico y rehabilitador. Se realizó una revisión documental de artículos de investigación, capítulos de libros y libros en diversas bases de datos donde se analizaron 55 fuentes documentales utilizando como técnica el análisis documental a partir del instrumento de la regilla documental. Entre los resultados se destaca que los problemas sobre los que ha girado el estudio de la discapacidad han sido en educación inclusiva, desarrollo humano, justicia social, estudios decoloniales y críticos de la discapacidad, y alrededor de la identidad y el reconocimiento. Se concluye que aún prevalece una mirada a la discapacidad y las personas con discapacidad desde la deficiencia, la superación, la rehabilitación y la limitación, y aunque existen estudios que interpelan a los sujetos con discapacidad, en estos prevalecen los abordajes alrededor de los obstáculos o elementos facilitadores para la inclusión.
Emlő pyoderma gangraenosuma – Esetbemutatás
Authors: Teknős Dániel , Simsay Laura , Váradi Gábor , Trávnyik Szilvia , Bíró Erik , Grics László , Lellei Ilona , El-Meouch Hicham 
Published: August 2022

Az emlő bőrén kialakuló pyoderma gangrenosum egy igen ritka, hirtelen kezdődő ulceratív betegség. Hátterében leggyakrabban szisztémás kórok áll, a gyulladásos bőrelváltozás kialakulását leggyakrabban műtét vagy trauma indítja be. A betegség korai diagnózisa és megfelelő kezelése igazi kihívás. Egy diabetes mellitusban szenvedő nőbeteg emlőjének bőrén minor sérülést követően kialakult pyoderma gangrenosum esetét mutatjuk be. Kezdetben bakteriális fertőzésként kezeltük, később a pontos diagnózis birtokában terápiánkat szisztémás szteroidokra váltottuk, végül a beteg kérésére emlőjét abláltuk.
Modulation of miR-192/NF-κB/ TGF-β/ E-cadherin by thymoquinone protects against diethylnitrosamine /carbon tetrachloride hepatotoxicity
Authors: Ashour Hend , Farghaly Maha Eid , Khowailed Akef Abdelhalim , Aboulhoda Basma Emad , Rashed Laila Ahmed , Elsebaie Mohamed Mahmoud , Gaber Safy Salah 
Published: August 2022

Abstract
Scientific efforts have been made for a better understanding of the pathogenesis of hepatocellular carcinoma (HCC). We investigated the possible role of miR-192/nuclear factor-κB (NF-κB)/transforming growth factor-β (TGF-β)/E-cadherin in hepatic tumorigenesis. We expected a modulatory impact of thymoquinone. Thirty adult male rats were assigned into 3 groups (n = 10); (1) Control group. Group (2): Experimental HCC induced by intraperitoneal injection of diethylnitrosamine (DENA) followed by carbon tetrachloride (CCl4). Group (3): Thymoquinone 20 mg kg−1/oral supplementation starting from the model induction to the end of the 8th week. The HCC (DENA-CCL4) model was confirmed by elevated serum levels of alpha-fetoprotein and transaminases (ALT, AST) and by histopathological examination which denoted marked cellular atypia and features of neoplasia. Suppressed hepatic miR-192 and E-cadherin expression were detected in the HCC (DENA-CCL4) group accompanied by elevated tumor necrosis factor (TNF-α), interleukin (IL6)/NF-κB & TGF-β1. Thymoquinone treatment protected the rat livers from hepatic tumorigenesis. Thymoquinone diminished (P < 0.001) alpha-fetoprotein and improved ALT, AST. It preserved hepatic miR-192 and normal E-cadherin expression. Thymoquinone-treated rats showed abrogated TNF-α, IL6/NF-κB/TGF-β. Thymoquinone increased cell apoptosis markers Bax/Bcl2 and diminished cellular atypia. Pearson's correlations revealed positive association between miR-192 expression and E-cadherin and Bax/Bcl2 as well, and it was negatively correlated to alpha-fetoprotein, NF-κB and TGF-β and the cellular atypia score. In conclusion, thymoquinone protected the liver tissues through preserving miR-192 and E-cadherin and aborting NF-κB & TGF-β signaling. The current results highlight a new role for thymoquinone in preventing hepatic tumorigenesis.
Conditions near a crack tip: Advanced experiments for dislocation analysis and local strain measurement
Authors: Gammer Christoph , An Dayong 
Published: August 2022

AbstractThe local stress state and microstructure near the crack-tip singularity control the fracture process. In ductile materials multiple toughening mechanisms are at play that dynamically influence stress and microstructure at the crack tip. In metals, crack-tip shielding is typically associated with the emission of dislocations. Therefore, to understand crack propagation on the most fundamental level,in situtechniques are required that are capable to combine imaging and stress mapping at high resolution. Recent experimental advances in x-ray diffraction, scanning electron microscopy, and transmission electron microscopy enable quantifying deformation stress fields from the bulk level down to the individual dislocation. Furthermore, through modern detector technology the temporal resolution has sufficiently improved to enable stress mapping duringin situexperiments.Graphical abstract
Iniciativas en la comunicación móvil: Mapeo de los canales, el contenido, la conversación y el comercio en Europa y los EE.UU
Authors: Silva Rodríguez Alba , López García Xosé , Westlund Oscar , Ulloa Erazo Nancy Graciela 
Published: August 2022

La implantación global de la telefonía móvil y el espectacular crecimiento del parque de smartphones y tabletas ha animado a la industria de los medios de comunicación a una clara apuesta por el diseño de estrategias para la elaboración de productos de contenidos pensados para los nuevos dispositivos.
Este artículo presenta los resultados de catorce plataformas de medios digitales, 14 de ellas europeas y una de EE.UU. El trabajo analiza las similitudes y diferencias en sus iniciativas con el fin de observar cómo producen contenidos para diferentes canales y gestionan la conversación y el comercio. Para este propósito se ha usado una metodología mixta que combina técnicas cuantitativas y cualitativas de recopilación de la información. El análisis de contenido se centra en los sitios de noticias y sus apps móviles. Los resultados muestran que el contenido de la información en los móviles es principalmente textual pero también incluye fotografías. Hay limitadas posibilidades para la conversación y los proveedores de contenido informativo no se aprovechan de las características específicas de los dispositivos móviles.
O estado de arte da Comunicação Organizacional: as tendências do século XXI
Authors: Silva Sónia , Ruão Teresa , Gonçalves Gisela 
Published: August 2022

A comunicação no contexto das organizações está em constante reconfiguração. As novas formas de informação, de interação, de partilha e de consumo que caracterizam as sociedades atuais trazem novos desafios às organizações e às suas estruturas comunicativas e tal justifica, sempre que possível, uma incursão pelo campo da Comunicação Organizacional com a principal motivação de compreender o estado atual da disciplina e acompanhar as suas tendências de investigação.
Tal é o propósito deste estudo: averiguar o estado da arte da Comunicação Organizacional recuando, para isso, às origens da disciplina e às suas preocupações fundacionais, as quais são fundamentais para compreender as abordagens que descrevem o campo no século XXI. Com esta análise pretendemos traçar as tendências de investigação da disciplina a abordar os principais desafios que caracterizam a relação entre comunicação e organização na atualidade.
Para cumprir este objetivo, recorremos a uma metodologia qualitativa, através da análise de vários artigos científicos e de livros publicados no âmbito dos estudos da Comunicação Organizacional (desde o aparecimento da disciplina), os quais nos permitiram entender e descrever as abordagens, os paradigmas, as metodologias, os temas e as tendências que protagonizaram a criação e o avanço desta disciplina. Trata-se, portanto, de uma revisão da literatura que privilegiou os trabalhos de académicos e investigadores reconhecidos nesta área científica. A sua análise foi fundamental para descrever os quatro paradigmas que se desenvolveram campo da Comunicação Organizacional: o positivista, o interpretativo, o crítico e o constitutivo.
Percebemos, como conclusão, que estas abordagens convivem harmoniosamente na tentativa de explicar o ambiente organizacional atual, o qual parece ter como principais desafios a constante evolução das tecnologias de informação e comunicação, que atribuem mais poder aos públicos e enfatizam os processos de comunicação relacional e a importância de comportamentos organizacionais éticos e responsáveis no seio de uma sociedade cada vez mais exigente e informada. Assim, também a comunicação enquanto estratégia tem conquistado espaço nas tendências de investigação em Comunicação Organizacional, como um tipo de comunicação que procura apoiar a missão da organização ao mesmo tempo que procura estabelecer relações profícuas entre a organização e os seus públicos.
Este é, portanto, um trabalho de sistematização de abordagens e de tendências que procura identificar o estado atual do estudo da Comunicação Organizacional, destacando-se quer pela apresentação da evolução do campo no século XXI quer, principalmente, pela sua apresentação em língua portuguesa, algo que é pouco comum nesta disciplina.
¿Cómo tener resultados de elite con la tecnología?: el rol de los andamiajes digitales en la apropiación de tecnologías digitales por clase social
Authors: Matozo Victoria 
Published: August 2022

En el cruce entre los estudios de desigualdad social y digital, este artículo presenta los resultados de una investigación finalizada sobre la apropiación de tecnologías digitales (TD) en estudiantes de nivel medio de la Ciudad Autónoma de Buenos Aires (CABA). Las estrategias por clase de movilidad social son las que teóricamente se suman al desarrollo del concepto de brecha digital y apropiación para analizar la acumulación de capital digital en esta población a partir de la clase de origen de los individuos.
En primer lugar este trabajo presenta una tipología sobre las apropiaciones juveniles, marcando los destinos esperables a partir de las trayectorias de apropiación digital por clase social. En segundo lugar se presentan los casos disidentes en los que jóvenes de diferentes clases sociales se han apropiado de TD de forma “inesperada”, es decir, dando cuenta una trayectoria con destinos diferentes a otros jóvenes de la misma clase social a partir de la influencia de andamiajes digitales. Estos andamiajes serán fuente de reflexión ya que posibilitan el cambio de trayectorias y la movilidad social y digital, pudiendo ser otros individuos e incluso políticas públicas.
Differentiated strategies for digital innovation on television: Traditional channels vs. new entrants
Authors: Ranaivoson Heritiana , Farchy Joëlle , Gansemer Mathilde 
Published: August 2022

Digitization has greatly influenced the functioning of the television industry. This paper analyzes in particular how French television channels have innovated and adapted to digital technologies. We begin with a typology of innovation in the media by drawing a distinction between product innovations and process innovations, as well as between companies according to whether they were the first to adopt an innovation, or only adopted it once it was already well established in the field. A total of 21 criteria for innovation are analyzed for each of the 15 TV channels in our sample.
This paper shows that TV channels have varied innovation strategies. Rather than some channels being innovators on all criteria and others being followers on all criteria, we show that channels adopt, more or less rapidly, certain types of innovation according to the channels’ characteristics. The characteristics that play the greatest role are the age of the channel, whether it is public or private, and whether it is general or thematic.
Inevitabilidade Digital: O Poder dos Laços Fracos, Convergência e Curiosidade na Disseminação do Stuxnet
Authors: Ramos Hugo Filipe 
Published: August 2022

Este artigo debate o conceito da inevitabilidade digital no contexto da ciberguerra e está organizado em quatro partes. Os quatro temas discutidos são: o enquadramento internacional do novo tipo de guerra, a contextualização histórica do Stuxnet, os conceitos e princípios da análise de redes em ciências sociais e, por fim, a apresentação do conceito de inevitabilidade digital.
O conceito de inevitabilidade digital envolve três princípios: a força dos laços fracos, a convergência das redes na rede e o poder motivador da curiosidade como motor do comportamento humano. A análise deste conceito é feita sobre o caso real da rede de disseminação do Stuxnet, desde a sua concepção até à entrada na rede privada e segura da central nuclear de Natanz.