bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Research On Cognitive Frailty: A Bibliometric and Visual Analysis of Papers Published During 2013 – 2021
Authors: Hui Zhaozhao , Wang Xiaoqin , Zhou Ying , Li Yajing , Ren Xiaohan , Wang Mingxu 
Published: January 2022

Abstract
Background: Cognitive frailty relates to various adverse health outcomes of older adults and is proposed as a new target of healthy ageing. This study aimed to analyze the status, hotspots, and emerging trends / frontiers of global research on cognitive frailty.Methods: Articles and reviews related to cognitive frailty of older people published from 2013 to 2021 were retrieved from the Web of Science Core Collection (WoSCC) database on 26 November 2021. CiteSpace 5.8.R3 was used to conduct the collaboration analysis, document co-citation analysis, and keyword co-occurrence analysis.Results: A total of 2,077 publications were included. There has been a rapid growth of publications on cognitive research since 2016. The United States, Italy, England, and Australia were the leading research centers of cognitive frailty; however, China has recently focused on this topic. The National Center for Geriatrics and Gerontology and Shimada H. were found to be the most prolific institution and author, respectively. Co-citation analysis identified 16 clusters, of which the largest was cognitive frailty. The most frequently occurred keyword was older adult, followed by cognitive impairment, frailty, risk, dementia, prevalence, mortality, health, and Alzheimer’s disease. Burst keyword detection revealed a rising interest in cognitive frailty models.Conclusions: By analyzing the publications over the past years, this study provides a comprehensive analysis of cognitive frailty research. A variety of visualized networks oﬀer an in-depth understanding of the countries / regions, institutions, authors, hotspots, and research frontiers.
Incidence of Postoperative Cognitive Dysfunction Following Inhalational Vs. Total Intravenous General Anesthesia: A Systematic Review and Meta-Analysis.
Authors: Negrini Daniel , Wu Andrew , Oba Atsushi , Harnke Ben , Ciancio Nicholas , Krause Martin , Clavijo Claudia , Al-Musawi Mohammed , Linhares Tatiana , Fernandez-Bustamante Ana , Schmidt Sergio 
Published: January 2022

Abstract
Postoperative cognitive dysfunction (POCD) has been increasingly recognized as a contributor to postoperative complications. A consensus-working group recommended that POCD should be distinguished between delayed cognitive recovery, i.e., evaluations up to 30 days postoperative, and neurocognitive disorder, i.e., assessments performed between 30 days and 12 months after surgery. Additionally, the choice of the anesthetic, either inhalational or total intravenous anesthesia (TIVA) and its effect on the incidence of POCD, has become a focus of research. Our primary objective was to search the literature and conduct a meta-analysis to verify whether the choice of general anesthesia may impact the incidence of POCD in the first 30 days postoperatively. As a secondary objective, a systematic review of the literature was conducted to estimate the effects of the anesthetic on POCD between 30 days and 12 months postoperative. For the primary objective, an initial review of 1,913 articles yielded 12 studies with a total of 3,639 individuals. For the secondary objective, five studies with a total of 751 patients were selected. In the first 30 days postoperative, the odds-ratio for POCD in TIVA group was 0.60 (95% CI = 0.40 - 0.91; p = 0.02), compared to the inhalational group. TIVA was associated with a lower incidence of POCD in the first 30 days postoperatively. Regarding the secondary objective, due to the small number of selected articles and its high heterogeneity, a metanalysis was not conducted. Giving the heterogeneity of criteria for POCD, future prospective studies with more robust designs should be performed to fully address this question.
LSALO-BP: A Hybrid Model for Children Adulthood Height Prediction
Authors: Mao Keji , Chen Lijian , Fan Xinben , Mao Jiafa , Zhou Xiaolong , Fang Kai 
Published: January 2022

Abstract
The prediction of children's adult height is a common procedure in childhood endocrinology. Through the prediction of children's adult height, it is possible to find abnormalities in children's growth and development. Many jobs in today's society have certain requirements for height, so the accuracy of children adulthood height prediction is important for children. Current methods for predicting adult height of children have some shortcomings such as inaccurate accuracy. To deal with these problems, this paper analyzes the data collected by the Chinese children and adolescents' physical and growth health projects in primary and secondary schools in Zhejiang Province, and proposes a method for predicting adult height based on back propagation neural network (BPNN) with the body composition of children and adolescents as input. Since the BP algorithm has the risk of falling into local optimization, and we propose LSALO-BP model that incorporates the ant lion optimizer (LSALO) into the BP algorithm as location strategy to avoid local optimization. The improvements achieved by the ant lion algorithm are mainly reflected in: improving the ant's walk mode, and enhancing the global search ability of the LSALO algorithm. The comparison experiment of 10 benchmark functions proves the feasibility and effectiveness of the location strategy. The LSALO-BP model is applied to the prediction of adult height of children and adolescents. The experimental results show that compared with other models, the LSALO-BP prediction model has increased the prediction accuracy by 6.67%~16.08% for boys and 4.67%~6.6% for girls, which can more accurately predict the adult height of children and adolescents.
Kinetics of LYVE-1-Positive M2-Like Macrophages in Developing and Repairing Dental Pulp in Vivo and Their Pro-Angiogenic Activity in Vitro
Authors: Thoai Kieu Quoc , Tazawa Kento , Kawashima Nobuyuki , Noda Sonoko , Fujii Mayuko , Nara Keisuke , Hashimoto Kentaro , Han Peifeng , Okiji Takashi 
Published: January 2022

Abstract
Tissue-resident macrophages expressing lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) are found in multiple tissues and organs. We aimed to evaluate the dynamics and biological function of LYVE-1+ macrophages in dental pulp during post-injury tissue remodeling. Immunofluorescence staining of mouse embryos revealed that LYVE-1+ macrophages colonized dental pulp before birth. In mature rat molar dental pulp, LYVE-1+ macrophages were the main subset of macrophages expressing CD163, an M2 marker, and were distributed throughout the tissue. In response to dental pulp injury induced by cavity preparation, LYVE-1+ macrophages quickly disappeared from the affected area of the pulp and gradually repopulated during the wound healing process. RAW264.7 mouse macrophages cultured with a mixture of macrophage colony-stimulating factor, interleukin-4, and dexamethasone increased LYVE-1 expression, whereas lipopolysaccharide-stimulation decreased LYVE-1 expression. Enforced expression of Lyve1 in RAW264.7 cells resulted in increased mRNA expression of matrix metalloproteinase 2 (Mmp2), Mmp9, and vascular endothelial growth factor A (Vegfa). Lyve1-expressing macrophages promoted the migration and tube formation of human umbilical vein endothelial cells. In conclusion, LYVE-1+ tissue-resident M2-like macrophages in dental pulp showed dynamism in response to pulp injury, and possibly play an important role in angiogenesis during wound healing and tissue remodeling.
Loss of Gucy1a3 Causes Poor Post-Stroke Recovery by Reducing Angiogenesis Via the HIF-1α/VEGFA Signaling Pathway in Mice
Authors: Luo Man , Mo Dongcan , Liu LiuYu , Li Jianli , Lin Jing , Liang Jie , Ye Fei , Wu Xiaoju , Li Xiaoling , Li Jiaoxing , Sheng Wenli 
Published: January 2022

Abstract

Ischemic stroke is a common and debilitating disease that can cause permanent neurological damage. Gucy1a3, which encodes the α1 subunit of soluble guanylyl cyclase, has been reported to be associated with functional recovery after ischemic stroke. However, the mechanism is still not well understood. In the present study, we investigated the effects of Gucy1a3 on (i) post-stroke recovery; (ii) vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF-1α) expression; and (iii) angiogenesis after ischemic stroke. A permanent middle cerebral artery occlusion (pMCAO) model was established using wild-type and Gucy1a3 knockout C57BL/6J male mice. Neurological deficits, infarct volume, microvascular density, and VEGFA and HIF-1α expression levels of mice were evaluated. Our results suggest that loss of Gucy1a3 increased the infarct volume and aggravated neurological deficits after pMCAO. In addition, the Gucy1a3 knockout brains exhibited significantly lower microvessel densities and VEGFA and HIF-1α expression levels than the wild-type brains at 96 hours post-pMCAO. The study shows that the expression of GUCY1A3 after ischemic stroke may play a substantial role in neurological function recovery and is related to angiogenesis in the peri-infarct region. The beneficial effects of GUCY1A3 might be mediated through the HIF-1α/VEGFA signaling pathway.
Comparison of Different Spatial Regression Methods for Predicting Organic Matter Content in Soil
Authors: Zhang Xumeng , Zhang Wuping , Huang Mingjing , Gao Li , Qiao Lei , Wang Guofang , Yan Linlin 
Published: January 2022

Abstract
Dynamic changes in soil organic matter content affects the sustainable supply of soil water and fertilizer and impacts the stability of soil ecological function. Understanding the spatial distribution characteristics of soil organic matter will help deepen our understanding of the differences in soil organic matter content, soil formation law; such understanding would be useful for rational land use planning. Taking terrain data, meteorological data, and remote sensing data as auxiliary variables and the ordinary Kriging (OK) method as a control, this study compares the spatial prediction accuracies and mapping effects of various models (MLR, RK, GWR, GWRK, MGWR, and MGWRK) on soil organic matter. Our results show that the spatial distribution trend of soil organic matter predicted by each model is similar, but the prediction of composite models can reflect more mapping details than that of unitary models. The OK method can provide better support for spatial prediction when the sampling points are dense; however, the local models are superior in dealing with spatial non-stationarity. Notably, the MGWR model is superior to the GWR model, but the MGWRK model is inferior to the GWRK model. As a new method, the prediction accuracy of MGWRK reached 47.72% for the OK and RK methods and 40.08% for the GWRK method. The GWRK method achieved a better prediction accuracy. The influence mechanism of soil organic matter is complex, but the MGWR model more clearly reveals the complex nonlinear relationship between soil organic matter content and factors influencing it. This research can provide reference methods and mapping technical support to improve the spatial prediction accuracy of soil organic matter.
Association Between Levels of Radon And Bioaerosols (Bacteria And Fungi) By Living Conditions
Authors: Hwang Sung Ho , Lee Sangwon , Won Jong-Uk , Cha Hyo Soung , Park Wha Me 
Published: January 2022

Abstract
This study aimed to measure the levels of airborne radon (Rn) and bioaerosols—culturable airborne bacteria (CAB) and culturable airborne fungi (CAF)—in South Korea’s residential environments, considering living conditions such as the number of ventilations, number of windows, floors, temperature, and relative humidity. These levels were evaluated for 32 houses of residents from the socially vulnerable class. Rn gas and bioaerosols were sampled twice: in fall and summer. A self-report survey gathered residents’ information on their general characteristics (daily residence time, heating and cooking type, cleaning and washing cycle, etc.) and health condition scores (0–100 points) on the day of sampling. The range of Rn levels was 0.43–7.439 pCi/L with a median of 0.70 pCi/L. The CAB levels were 239–488 colony-forming unit (CFU)/m3 with a median of 309 CFU/m3, and CAF levels were 174–366 CFU/m3 with a median of 233 CFU/m3. Thus, this study found that semi-basement residential indoor environments negatively affected Rn and bioaerosol levels, and living in such residences resulted in high health condition scores.
Knowledge, Attitude and Practice of Skin Whitening Products, Among Sudanese Undergraduate Females, 2021.
Authors: Khalil Reham Abdulrahman 
Published: January 2022

Abstract
Objectives: The knowledge, attitude and practice of skin-whitening products among female undergraduates in the medical campus, University of Khartoum.Methods: A cross-sectional study was conducted at the medical campus of University of Khartoum. All consenting female undergraduates were included in the study population. 417 women were chosen through proportional stratified random sampling, and were asked to complete a questionnaire.365 completed the questionnaire with a response rate of 87%. Result: 365 women completed the questionnaire, of whom 52% had average knowledge, 32% had poor knowledge and 16% had excellent knowledge,.32% had a positive attitude, and 38% reported using skin-whitening products.Knowledge, attitude and practice were associated with several factors.Conclusion : Although The overall knowledge about skin-whitening products is average. The knowledge about skin-whitening agents is rather poor. The majority of Sudanese University students have a negative attitude towards skin-whitening, but still the use of skin-whiteners is common amongst them .. Women who feel pressured by society to whiten their skin, are more likely to use skin-whiteners, as well as those who have a family history of skin-whitening. Media and social media play an important role in this matter, being the most important source of information and the most common factor pressuring women to lighten their skin as well. We recommend media and social to be used to promote the acceptance of dark skin and raise awareness about the safe practice of skin whitening. We also recommend that the Ministry of Health and Standards and Metrology Authority mandate the labeling of all products sold in Sudan detailing ingredients and concentrations of ingredients.
Assessment of Patient Satisfaction with Treatments for Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study
Authors: Lu Huanhuan , Ma Yiming , Zeng Huihui , Zeng Yuqin , Chen Ping , Chen Yan 
Published: January 2022

Abstract
Purpose: Patient satisfaction with treatment is associated with adherence to therapy. This study aimed to investigate the treatment satisfaction level of patients with chronic obstructive pulmonary disease (COPD) and to explore the underlying factors associated with patient satisfaction. Methods: A cross-sectional study was conducted in ambulatory patients at the Second Xiangya Hospital, Changsha, Hunan, between August 1, 2020, and May 31, 2021. The Treatment Satisfaction Questionnaire for Medication version II (TSQM v. II) was used to assess the treatment satisfaction of patients. Multivariable regression analysis was used to determine the factors associated with treatment satisfaction. Results: 392 ambulatory patients with COPD first participated in the study, and 354 patients with are finally available. Median (IQR) score in effectiveness was 66.67(50.00, 66.67), in side effects was 100(100,100), in convenience was 66.67(66.67, 66.67), in global satisfaction was 66.67(50.00, 66.67).Compared with the unsatisfied group, the patients who were satisfied with the treatment had fewer acute exacerbations in the past year (0 vs 1,p＜0.001), lower CAT scores(10 vs 13, p＜0.001), lower CCQ scores(1.95 vs 2.24, p＜0.001), lower GOLD group classification(p＜0.001) and lower BODE index[3.00(1.00, 4.25) vs 3.00(2.00, 5.00), p=0.006]. Results indicate that different bronchodilator treatment didn't impact the satisfaction with treatment. The multivariable regression analysis showed that global satisfaction was associated positively with mMRC(β=2.814, p=0.027),while inversely with BMI(β=-0.542, p=0.014), FEV1%predicted(β=-0.135,P=0.024), CAT score(β=-0.342,p=0.033), BODE index(β=-2.057,p=0.023). Conclusion: The results of this study showed that the patients’ satisfaction with treatments is not high in COPD. Different bronchodilator treatment didn't impact the satisfaction with treatment. Keywords: chronic obstructive pulmonary disease, treatment satisfaction, TSQM v. II, bronchodilator
ZbSR: A Data Plane Security Model of SR-BE/TE based on Zero-Trust Architecture
Authors: Wang Liang , Ma Hailong , Li Ziyong , Pei Jinchuan , Hu Tao , Zhang Jin 
Published: January 2022

Abstract
Facing the untrusted threats of network elements and PKI/CA faced by SR-BE/TE(Segment Routing-BE/TE) data plane in the zero-trust network environment, firstly, this paper refines it into eight specific security issues. Secondly, an SR-BE/TE data plane security model ZbSR(ZTA-based SR) based on zero-trust architecture is proposed, which reconstructs the original SR control plane into a "trust-agent" two-layer plane based on 4 components of the controller, agent, cryptographic center and information base. On one hand, we distinguish between the two segment list generation modes and proposes corresponding data exchange security algorithms, by introducing north-south security verification based on identity authentication, trust evaluation, and key agreement before the terminal device establishes an east-west access connection, so reliable data exchange between terminal devices can be realized. On the other hand, for the network audit lacking SR-BE/TE, a network audit security algorithm based on solid authentication is proposed. By auditing the fields, behaviors, loops, labels, paths, and SIDs of messages, threats such as stream path tampering, SID tampering, DoS attacks, and loop attacks can be effectively detected. Finally, through the simulation test, the proposed model can provide security protection for the SR data plane with a 19.3% average incremental delay overhead for various threat scenarios.
The Impact of Direct Challenges to Student Endorsement of Teleological Reasoning on Understanding and Acceptance of Natural Selection
Authors: Wingert Jason , Bassett Gennie , Terry Caitlin , Lee Jimin 
Published: January 2022

Abstract
Background: Teleological reasoning is a cognitive bias purported to disrupt student ability to understand natural selection. Few studies have described pedagogical efforts to decrease student endorsement of teleological reasoning and measure the effects of this attenuation on the understanding and acceptance of evolution. This study examined the influence of explicit instructional activities directly challenging student endorsement of teleological explanations for evolutionary adaptations on their learning of natural selection over a semester-long undergraduate course in evolutionary medicine. In a convergent mixed-methods design this study combined pre- and post-semester survey data (N = 83) on understanding natural selection, student endorsement of teleological reasoning, and acceptance of evolution, with thematic analysis of student reflective writing on their understanding and acceptance of natural selection and teleological reasoning.Results: Student endorsement of teleological reasoning decreased and understanding and acceptance of natural selection increased during a course on human evolution with teleological intervention (p£0.0001), compared to a control course. Endorsement of teleological reasoning was predictive of understanding of natural selection prior to the semester. Thematic analysis revealed that students were largely unaware of the concept of teleological reasoning prior to the course, but perceived attenuation of their own teleological reasoning by the end of the semester. Conclusions: Students are unaware of their high levels of endorsement of teleological reasoning upon entrance into the undergraduate human evolution course, which is consequential because teleological reasoning is a predicter of natural selection understanding. We developed class activities to directly challenge student endorsement of unwarranted design teleological reasoning. As a result, students had decreased unwarranted teleological reasoning and increased acceptance and understanding of natural selection over the course of the semester. The data presented show that students are receptive to explicit instructional challenges to their teleological reasoning and that attenuation of this bias is associated with gains in natural selection understanding and acceptance.
Seroprevalence and associated risk factors of canine Leishmania infantum infection in selected towns of Southwest and West Shewa Zones of Oromia, Ethiopia
Authors: Gebremedhin Endrias Zewdu , Weya Weraka , Dima Chala , Zewde Demeke , Presti Vincenzo Di Marco Lo , Vitale Maria 
Published: January 2022

Abstract
Background

Canine Leishmania infantum infection is a major vector-borne zoonosis. Most cases of canine leishmanias are caused by Leishmania infantum, but other species can also be found. In the Old and New Worlds, leishmaniasis is spread by the bite of phlebotomine female sandflies of the genera Phlebotomus and Lutzomyia respectively. The objectives of the study were to estimate the seroprevalence and associated risk factors in Weliso, Ambo, and Ejaji towns of South-West and West Shewa Zones, Oromia, Ethiopia.
Methods

A cross-sectional study was conducted from October 2019 to September 2020. The study population consists of dogs found in the study towns. The study subjects include 368 dogs selected by using a simple random sampling method. A blood sample (5 ml) was collected to test for the presence of rK39 antigen inducing specific antibodies using an Indirect ELISA kit. All the data were analyzed using the STATA version 14 software program. Pearson’s Chi-square and logistic regression tests were used to evaluate the association between the seropositivity of canine Leishmania infantums and hypothesized risk factors.
Results

An overall canine Leishmania infantum seroprevalence of 84.24% (95% confidence interval [CI]: 80 - 88%) was obtained. In Weliso, Ambo, and Ejaji towns canine Leishmania infantum seroprevalence of 79.82% (95% CI: 71- 87%), 76.11% (95% CI: 67- 84%), and 93.84% (95% CI:89 – 97%) were found respectively. Univariable logistic regression analysis showed that town (P=0.001), season (P=0.001), mixed living environment (P=0.003), and Kebele (P<0.05) were significantly associated with Leishmania infantum seropositivity. However, the multivariable analysis indicated that wet season (P = 0.001) and a mixed living environment (P = 0.025) were independent predictors of canine Leishmania infantum seropositivity.
Conclusion

The seroprevalence of canine Leishmania infantum in dogs was very high. Wet season and mixed living environment are predictors of seropositivity. The high percentage of seropositive dogs indicates the potential role of dogs to maintain the infection and the possible spread of L. infantum infection to humans. Therefore, improvement of the living environment and health care facilities of domesticated dogs, community awareness and health education, and further epidemiological studies are suggested.