bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes in Obese vs Non-Obese Injured Patients at a Level 1 Trauma Center and Bariatric Surgery Center of Excellence
Authors: Petrone Patrizio , Joseph D’Andrea K. , Baltazar Gerard , Akerman Meredith , Howell Raelina S. , Brathwaite Collin E. M. 
Published: March 2022

Background We hypothesized that the outcomes of trauma patients with a body mass index (BMI) equal to or greater than 30 compared to patients with BMI less than 30 would not differ at a level 1 trauma center that is also a Metabolic and Bariatric Surgery Center of Excellence in the Metabolic and Bariatric Surgery Accreditation Quality Improvement Program (MBSAQIP). Study Design Patients equal to and greater than 18 years old treated between 1/1/2018 and 12/31/2020 were included. Demographics, BMI, comorbidities, and outcomes (hospital-LOS, ICU-LOS, blood products used, and mortality) were compared between 2 groups: obese (BMI ≥30) vs non-obese (BMI <30). Results Of the 4192 patients identified, 3821 met the inclusion criteria; 3019 patients had a BMI <30, and 802 had a BMI ≥30. There was a statistically significant difference between the 2 groups with respect to gender (females: 57% vs 47%, P < .0001) and age (median: 80 [IQR: 63-88] vs 69 [IQR: 55-81], P < .0001). When adjusted for age, sex, DM, dementia, ISS, and ICU admission, there was no statistically significant difference in hospital-LOS (4.30 [95% CI: 4.10, 4.52] vs 4.48 [95% CI: 4.18, 4.79]) or mortality. No statistical differences were seen between the 2 groups in blood product use. Conclusions Obesity did not correlate with poorer outcomes at an ACS-verified level 1 Trauma Center and Bariatric Surgery Center of Excellence. Further studies are needed to determine whether outcomes vary at hospitals without both designations.
Treatment of venous malformations with tumescent-assisted sclero-embolic and ablative lasers (SEALs): Safe and effective long-term outcomes
Authors: Kang Mina , Connor David E , Parsi Kurosh 
Published: March 2022

Background Perivascular infiltration of tumescent anaesthesia (TA) is an essential element of endovenous thermal ablative procedures employed to treat superficial venous disease. In addition to anaesthesia, TA is administered to achieve vessel wall approximation and to protect surrounding structures from thermal damage. However, its role in the treatment of venous malformations (VMs) has not been established. Objectives To assess the safety and efficacy of tumescent-assisted thermal and chemical ablative methods in the treatment of VMs. Methods Adult and paediatric patients presenting with VMs were treated using a combination of endovenous laser ablation, foam embolo-sclerotherapy and liquid embolisation using n-BCA. All procedures were ultrasound-guided. Treatment outcomes were assessed in early and late follow-ups. To assess the efficacy of TA in achieving vessel wall approximation, cross-sectional lesional diameters were measured by ultrasound, before and after the administration of TA during endovenous procedures. Results In a 12 month period, 22 patients recruited in the study presented with 27 VMs which included 23 extra-truncular lesions (16 subcutaneous and seven intramuscular) and four truncular anomalies. On average the subcutaneous lesions measured 5.5 mm (1.9–24.5 mm) in diameter, intramuscular lesions measured 9.2 mm (5.9–15.1 mm) and truncular anomalies measured 4.9 mm (1.2–12 mm) in diameter. Perivascular infiltration of TA resulted in a significant reduction in vessel calibre (90% reduction on average). Intramuscular VMs were less compressible with TA (69.2% reduction) compared to subcutaneous lesions (98% reduction). Truncular anomalies such as the embryonic marginal vein achieved complete approximation (100% reduction). Procedures were safely tolerated with no major complications such as thromboembolism, stroke, nerve damage or tissue necrosis. Most patients had significant clinical as well as ultrasonographic improvement. Conclusion Tumescent-assisted endovenous laser ablation and foam sclerotherapy provides safe and effective outcomes in patients with a variety of VMs.
Sectoral Compositions of Output and Employment in India: Are We Moving Towards Jobless, Job-loss or Job-enabled Growth?
Authors: Das Ramesh Chandra 
Published: March 2022

Indian economy, after maintaining a very low growth rate in the pre-reform phase, experienced high growth rate of its income in the post-reform phase. But the sparking growth rates in India after the onset of the liberalisation policy has questioned its sustainability in terms of sufficient employment generations. The present study aims to find out whether the aggregate economy and the sectors within it are moving towards jobless, job-loss or job-enabled growth for the period 1973–2018. The study thus calculated the output elasticity of employment in total period and phase-wise periods, and obtained that the values of the output elasticity of employment show no sign of sparking employment growth like that of the income. The average values of the elasticity of employment lie mostly less than half which signify the emergence of jobless growth. In some years, there are job-loss growths as well, mainly in industrial sector. Hence, it can be inferred that the Indian economy is not going in the right directions so far as employment opportunity is concerned; putting a big question on attaining the sustainable developmental goal. JEL Classification: J21, J64, O10
Austerity in the United Kingdom and its legacy: Lessons from the COVID-19 pandemic
Authors: Arrieta Tania 
Published: March 2022

AbstractThe COVID-19 pandemic revealed that public institutions and some households in the United Kingdom (UK) were in a vulnerable and weak financial position to mitigate its immediate outcomes. Public institutions did not have the necessary resources to support their communities and low-income groups were disproportionally affected by the economic contraction of 2020–2021. This paper explores how the disastrous consequences of the pandemic were exacerbated by the implementation of an austerity programme, that as an extension of a neoliberal ideology, supported the development of the market at the expense of reducing the welfare state. Through an assessment of four trends that were reinforced during austerity—the four ‘Ds’—this article shows that austerity influenced many of the struggles observed during the pandemic. These trends are disinvestment, decentralisation, decollectivisation and disintegration. Despite the lessons learnt in 2020–2021 and the evident need to move away from a neoliberal agenda that dismantled the capacities of the state, this article concludes that neoliberalism continues to threaten the welfare state and the formation of social collectivities. Some expenditure decisions taken by the British government in 2020–2021 could further deepen social class divisions and regional inequalities. More is needed from the government to tackle these social problems and to build a fairer and more equal society.
A Systematic Review and Meta-analysis of Randomized Controlled Trials of Stabilizing Exercises for Lumbopelvic Region Impact in Postpartum Women With Low Back and Pelvic Pain
Authors: Moheboleslam Zohreh , Mohammad Rahimi Nasser , Aminzadeh Reza 
Published: March 2022

Background Countless women experience lumbopelvic pain (LBPP) after pregnancy. Physical activity is revealed as a beneficial procedure to alleviate LBPP, yet it appears that individual investigations report mixed conclusions about its effectiveness. Objective: This systematic review and meta-analysis examined the impact of stabilizing exercises on pain intensity, disability, and quality of life (QoL) in postpartum women. Data sources: A systematic search was conducted in PubMed, MEDLINE, Google Scholar, Scopus, and reference lists of included studies up to September, 2021. Study selection: Eleven studies comprising 623 participants were included and analyzed using a random-effects model. Results: Data displayed that stabilizing exercises significantly reduced pain (standard mean difference; SMD: −0.76, 95% confidence interval (CI): −1.26 to −0.27, p = .002), and disability (SMD: −1.19, 95% CI: −1.7 to −0.68, p < .001). However, our study found no significant change in QoL following stabilizing exercises (MD: 4.42, 95% CI: −5.73, 14.57, p = .39). Conclusion: Our systematic review and meta-analysis demonstrated that stabilizing interventions had some benefits in postpartum women. While there is some evidence to display the efficacy of stabilizing exercises for relieving LBPP, additional longer-term and high-quality studies are required to confirm the current findings.
Understanding the sleep of ultra-marathon swimmers: Guidance for coaches and swimmers
Authors: Dunican Ian C , Perry Emma L , Gemma Maisey , Nesci Elena , Roberts Spencer 
Published: March 2022

Open water swimming ultra-marathon events ≥10 km have become increasingly popular amongst master athletes. However, very little is known about the timing of training sessions and the impact on sleep. This study aimed to examine sleep behaviours, sleep problems and disorders and the relationship with training timings. This study used a longitudinal observational design for 42 nights with 24 masters' swimmers (n = 13 females), aged 39 ± 11 years, body mass index of 26 ± 3 kg/m2 during a training squad for an ocean ultra-swim (19.7 km) in Western Australia. Objective measures of sleep were obtained from a wrist-activity monitor, the Readiband™ (Fatigue Science Inc., Canada). Swimmers completed a survey instrument related to sleep problems, disorders, chronotype, anthropometric and demographic information. Generalised linear mixed models were fitted to examine relationships between predictor variables and sleep responses. Body mass index was associated with a decline in Total Sleep Time (TST), each one-unit increase in BMI was associated with 5 min less TST (p = 0.04). Swimmers with a “high risk” of sleep apnea had 21 min more wake time (p = 0.04) and 5% lower Sleep Efficiency (p = 0.04). Sleep Offset on the morning of a morning training session was earlier by 48 min (p < 0.001) resulting in less TST by 39 min (p < 0.001). This study provides evidence that coaches need to consider sleep behaviours and problems before designing training schedules. Swimmers need to plan and allocate an adequate sleep opportunity and those who have a suspected sleep disorder or problem should seek the support of a sleep physician.
Effects of Gradient and Speed on Uphill Running Gait Variability
Authors: Padulo Johnny , Ayalon Moshe , Barbieri Fabio A. , Di Capua Roberto , Doria Christian , Ardigò Luca P. , Dello Iacono Antonio 
Published: March 2022

Background: The aim of this study was to investigate the effects of gradient and speed on running variability (RV) and local dynamic stability (LDS) during uphill running. Hypotheses: (1) Both gradient and speed increase metabolic effort, in terms of heart rate (HR) and perceived exertion (CR10), in line with the contemporary literature, and (2) gradient increases RV and impairs LDS. Study design: “Crossover” observational design. Level of Evidence: Level 3. Methods: A total of 25 runners completed 10-minute running trials in 3 different conditions and in a randomized order: gradient at 0% (0CON), 2% (2CON), and 2% at isoefficiency speed (2IES). 0CON and 2CON speeds were calculated as the “best 10-km race performance” minus 1 km·h−1, whereas 2IES speed was adjusted to induce the same metabolic expenditure as 0CON. HR and perceived exertion as well as running kinematic variables were collected across all trials and conditions. Running variability was calculated as the standard deviation of the mean stride-to-stride intervals over 100 strides, while LDS was expressed by the Lyapunov exponent (LyE) determined on running cycle time over different running conditions. Results: Increases in HR and CR10 were observed between 0CON and 2CON ( P < 0.001) and between 2IES and 2CON ( P < 0.01). Higher RV was found in 2CON compared with 0CON and 2IES (both P < 0.001). Finally, the largest LyE was observed in 2IES compared with 0CON and 2CON ( P = 0.02 and P = 0.01, respectively). Conclusion: Whereas RV seems to be dependent more on metabolic effort, LDS is affected by gradient to a greater extent. Clinical Relevance: Running variability could be used to monitor external training load in marathon runners.
Changing paradigms of hemophilia care across larger specialized treatment centers in the European region
Authors: Windyga Jerzy , Boban Ana , Zupan Irena , O’Connell Niamh , Hermans Cedric 
Published: March 2022

Introduction: In early 2021, the European Collaborative Haemophilia Network (ECHN) conducted a survey to determine whether the paradigms of care across the European region have changed with the introduction of novel therapies for people with hemophilia. Methods: We conducted a survey in 19 ECHN centers from 17 countries in the European region. The aim was to track recent changes in the hemophilia treatment landscape, determine the impact of these changes on hemophilia treatment centers and comprehensive care centers in the region, and to look into the future of care as applied to people with hemophilia. The survey was structured to include three key areas: demographics and organization; current challenges and opportunities; and future directions. Discussion: Our survey provides a snapshot of the current approach to hemophilia treatment that highlights a move toward preventive, rather than reactive care, but that also raises a number of key concerns related to costs and accessibility (particularly as related to novel therapies), time limitations for clinical research, and ongoing issues regarding human resources (particularly in terms of new doctors entering the field) and availability of laboratory resources as the use of novel therapies (some with unique modes of action and unusual adverse events, some with specialized monitoring requirements) becomes commonplace. Conclusion: While our survey suggests that specialized care will continue to play a central role in the management of hemophilia, the standards and protocols, as well as the centers themselves, will have to continue to evolve if they are to continue to provide the highest level of care. To meet this requirement, there is a clear need for engaging, ongoing education programs for healthcare professionals working in the field of hemophilia that can be adjusted to the changing landscape of hemophilia therapy and monitoring.
Epidemiology and causes of intestinal obstruction in Ethiopia: A systematic review
Authors: Fekadu Gelana , Tolera Abebe , Beyene Bayissa Badhaasaa , Merga Bedasa Taye , Edessa Dumessa , Lamessa Adugna 
Published: March 2022

Objective: This systematic review was aimed to address the prevalence and causes of intestinal obstruction in Ethiopia. Methods: Systematic searches were conducted on PubMed, EMBASE, CINAHL, Scopus, African Journals Online, HINARI, and other supplementary sources, including Google Scholar. We conducted methodological quality assessments for the articles by employing a critical appraisal checklist of Joanna Briggs Institute. Results: The reported prevalence of intestinal obstruction in Ethiopia ranges from 18.6% to 50.7% among patients with acute abdomen. However, the prevalence varies from 4.3% to 34.6% among total surgical admissions. The leading causes of small intestinal obstruction were small bowel volvulus, intussusception, and adhesion. Sigmoid volvulus was the most commonly reported cause of large intestine obstruction, followed by colonic cancer. Conclusion: The highest reported prevalence of intestinal obstruction in Ethiopia was 50.7% among patients with acute abdomen and 34.6% among surgical admissions. Small intestine volvulus and sigmoid volvulus were the common causes of small and large bowel obstructions, respectively. Therefore, clinicians have to consider the common causes during the diagnosis and management of intestinal obstruction.
A COVID-19 forecasting system for hospital needs using ANFIS and LSTM models: A graphical user interface unit
Authors: Shafiekhani Sajad , Namdar Peyman , Rafiei Sima 
Published: March 2022

Background Centers for Disease Control and Prevention data showed that about 40% of coronavirus disease 2019 (COVID-19) patients had been suffering from at least one underlying medical condition were hospitalized; in which nearly 33% of them needed to be admitted to the intensive care unit (ICU) to receive specialized medical services. Our study aimed to find a proper machine learning algorithm that can predict confirmed COVID-19 hospital admissions with high accuracy. Methods We obtained data on daily COVID-19 cases in regular medical inpatient units, emergency department, and ICU in the time window between 21 July 2020 and 21 November 2021. Data for the first 183 days (training data set) were used for long short-term memory (LSTM) network, adaptive neuro-fuzzy inference system (ANFIS), support vector regression (SVR) and decision tree model training, whilst the remaining data for the last 60 days (test data set) were used for model validation. To predict the number of ICU and non-ICU patients, we used these models. Finally, a user-friendly graphical user interface unit was designed to load any time series data (here the trend of population of COVID-19 patients) and train LSTM, ANFIS, SVR or tree models for the prediction of COVID-19 cases for one week ahead. Results All models predicted the dynamics of COVID-19 cases in ICU and non- wards. The values of root-mean-square error and R2 as model assessment metrics showed that ANFIS model had better predictive power among all models. Conclusion Artificial intelligence-based forecasting models such as ANFIS system or deep learning approach based on LSTM or regression models including SVR or tree regression play a key role in forecasting the required number of beds or other types of medical facilities during the coronavirus pandemic. Thus, the designed graphical user interface of the present study can be used for optimum management of resources by health care systems amid COVID-19 pandemic.
Evaluating the Association of Face Covering Mandates on COVID-19 Severity by State
Authors: Strand Mark A. , Shyllon Omobosinuola , Hohman Adam , Jansen Rick J. , Sidhu Savita , McDonough Stephen 
Published: March 2022

Objective: During the COVID-19 pandemic in the United States, mitigation measures were implemented on a state-by-state basis. Governors were responsible for establishing interventions appropriate for their states and the timing of implementation. This paper evaluated the association between the presence and timing of a mask mandate and the severity of the COVID-19 epidemic by state. Methods: The states were divided into 3 categories based on when the governors of each state implemented a mask mandate: Early (mask mandate implemented between March 2020 and June 2020), Late (July 2020-December 2020), and Never (no mask mandate implemented). The rates of hospitalizations and mortality (per 100 000) were assessed at the different time points during the pandemic across these categories from March to December 2020. Results: The mortality rates across all 3 groups were observed to be highest in the beginning and toward the end of the pandemic in 2020 with the peak observed in the Early group between April and May 2020. Also, the rates of hospitalization increased steadily across all groups. The Early mask group was comprised of 86.7% and 13.3% states with Democratic and Republican governors respectively, and no states in the Never category had Democratic governors. Conclusion: These results support the benefit of implementing a mask mandate to minimize the impact of the COVID-19 pandemic and the role of political affiliation of governors on that impact.
Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies
Authors: Izquierdo Elena , Vorholt Daniela , Blakemore Stuart , Sackey Benedict , Nolte Janica L. , Barbarino Verena , Schmitz Jan , Nickel Nadine , Bachurski Daniel , Lobastova Liudmila , Nikolic Milos , Michalik Michael , Brinker Reinhild , Merkel Olaf , Franitza Marek , Georgomanolis Theodoros , Neuhaus René , Koch Maximilian , Nasada Niklas , Knittel Gero , Chapuy Björn , Ludwig Nicole , Meese Eckart , Frenzel Lukas , Reinhardt Hans Christian , Peifer Martin , Rebollido-Rios Rocio ,  Bruns Heiko , Krüger Marcus , Hallek Michael , Pallasch Christian P. 
Published: March 2022

Abstract
Genetic alterations in the DNA damage response (DDR) pathway are a frequent mechanism of resistance to chemoimmunotherapy (CIT) in B-cell malignancies. We have previously shown that the synergy of CIT relies on secretory crosstalk elicited by chemotherapy between the tumor cells and macrophages. Here, we show that loss of multiple different members of the DDR pathway inhibits macrophage phagocytic capacity in vitro and in vivo. Particularly, loss of TP53 led to decreased phagocytic capacity ex vivo across multiple B-cell malignancies. We demonstrate via in vivo cyclophosphamide treatment using the Eμ-TCL1 mouse model that loss of macrophage phagocytic capacity in Tp53-deleted leukemia is driven by a significant downregulation of a phagocytic transcriptomic signature using small conditional RNA sequencing. By analyzing the tumor B-cell proteome, we identified a TP53-specific upregulation of proteins associated with extracellular vesicles (EVs). We abrogated EV biogenesis in tumor B-cells via clustered regularly interspaced short palindromic repeats (CRISPR)-knockout (KO) of RAB27A and confirmed that the EVs from TP53-deleted lymphoma cells were responsible for the reduced phagocytic capacity and the in vivo CIT resistance. Furthermore, we observed that TP53 loss led to an upregulation of both PD-L1 cell surface expression and secretion of EVs by lymphoma cells. Disruption of EV bound PD-L1 by anti–PD-L1 antibodies or PD-L1 CRISPR-KO improved macrophage phagocytic capacity and in vivo therapy response. Thus, we demonstrate enhanced EV release and increased PD-L1 expression in TP53-deficient B-cell lymphomas as novel mechanisms of macrophage function alteration in CIT resistance. This study indicates the use of checkpoint inhibition in the combination treatment of B-cell malignancies with TP53 loss.