bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic analysis provides insights into the molecular regulatory mechanism of Dengzhan Shengmai capsule in a rat model of vascular dementia
Authors: Zhang Jing , Liu Wei , Wei Dongfeng , Zhao Guangyi , Li Jian , Zhang Zhanjun 
Published: August 2022

Abstract
Dengzhan Shengmai (DZSM) capsule is a compound Chinese medicine that is widely used in the clinic for the treatment of ischemic cerebrovascular diseases along with symptoms of dementia and forgetfulness. DZSM can improve the cognitive function and quality of life of patients with vascular dementia (VD), but little is known about the therapeutic mechanisms. In this study, we found that DZSM rescued spatial memory impairment in VD rats. We next employed an isobaric tag for relative and absolute quantitation (iTRAQ)-based quantitative proteomic approach to uncover the specific proteins and biological pathways underlying the exacerbation of cognitive deficits observed in VD and to investigate the molecular mechanism of the effect of DZSM against VD. We discovered that the proteome was broadly changed in VD rat brains; among the 222 identified proteins with altered expression after VD modeling, 136 were upregulated and 86 were downregulated. Gene ontology and ingenuity pathway analysis indicated that the altered proteins in VD brains strongly interacts with the TCA cycle, 14-3-3-mediated signaling, actin cytoskeleton signaling, the synaptogenic signaling pathway, etc. These top-ranked canonical pathways, key regulators of glucose metabolism, synaptic plasticity and synaptogenesis, were predicted to be downregulated in VD. We also examined the proteomic profile of DZSM-treated VD rat brains and identified 23 potential DZSM-targeting proteins. Our results suggest that DZSM may function by regulating key modulators, such as RAP1A and H2AFX, which are involved in signaling pathways important for neuronal functions. Our study offers resources to characterize the biological functions of DZSM regulating proteins and may aid in the identification of the molecular mechanism by which DZSM can treat VD.
Typing the tumor immune signatures in patients of Lynch syndrome facilitates predicting the responsiveness of immune checkpoint inhibition
Authors: Zheng Guoxing , Lu Yingsi , Yang Zheng , Chen Hong , Liang Qian , Zhu Qingqing , Li Yan , Xiao Xing , He Zhuzhen , Zhu Yifan , Li Bo , Huang Leilei , Dong Nan , Hu Shuang , Pan Yihang , Zhang Changhua , Zhu Chengming 
Published: August 2022

Abstract
Background: Although many efforts of predicting the responsiveness to immune checkpoint inhibition including expression of PD-L1 and MHC I, microsatellite instability (MSI), mismatch repair (MMR) defect, tumor mutation burden (TMB), tertiary lymphoid structures (TLSs) and several transcriptional signatures have been performed, the sensitivity remains to be further improved. Methods and Results: Here, we integrated T cell spatial distribution and intratumor transcriptional signals in predicting the response to immune checkpoint therapy in Lynch Syndrome (LS) which is featured with MMR deficiency. In all three cohorts, LS patients displayed the personalized tumor immune signatures of inflamed, immune excluded, and immune desert, which were not only individual-specific but also organ-specific. Furthermore, the immune desert exhibited more malignant indicated by low differentiation adenocarcinoma, larger tumor sizes, and higher metastasis rate. Moreover, the tumor immune signatures associated with distinct populations of infiltrating immune cells were comparable to TLSs and more sensitive than transcriptional signature gene expression profiles (GEPs) in immunotherapy prediction. Surprisingly, the tumor immune signatures might arise from the somatic mutations. Notably, LS patients had benefited from the typing of immune signatures and later immune checkpoint inhibition. Conclusions: Our findings suggest that compared to PD-L1 expression, MSI, MMR, TMB, and GEPs, characterization of the tumor immune signatures in Lynch syndrome improve the efficiency of predicting the responsiveness of immune checkpoint inhibition.
High-harmonic generation in polycrystalline CdTe nano-films via macroscopic investigations
Authors: Liang Houkun , Yang Hang , Long Zhe , Tian Kan , He Linzhen , Chen Zi-Yu , Zhao Dewei , Wu Han , Wu Lili , Sen Lin , Wang Qi Jie 
Published: August 2022

Abstract
Bright high harmonics generation (HHG) in CMOS-compatible nano-films can provide new opportunities for integrated coherent ultra-violet sources and attosecond photonic devices. Up to now, most HHG studies have been limited to single crystals. Polycrystalline materials, which consist of many grains separated by grain boundaries and normally have random crystallographic orientations as well as scattering propagation trait, have rarely been explored for HHG although they have diversified properties. Understanding and predicting the HHG properties in polycrystalline nano-films rather than in pristine bulks are important owing to its merits of low cost and large deposition area. However, it is a formidable challenge when considering complex effects of crystallite size and texture, grain boundaries, defects, surface states and nonlinear propagations. Here, we for the first time experimentally discover the correspondence between HHG in polycrystalline matters and macroscopic material parameters, to the best of our knowledge. Bright and long-term stable harmonics extending to 15th and 25th orders are demonstrated in polycrystalline cadmium telluride (CdTe) films with 6 nm and 50 nm thicknesses, respectively. It is found that the HHG strengths in the transmission and the reflection from the polycrystalline CdTe nano-films behave differently as a function of the material thickness in the range from 6 nm to 4 μm, which is highly correlated to the measured macroscopic conductivity. This work provides a simple gauge to study and predict HHG in complicated polycrystalline and amorphous nano-systems, and paves the way for novel strong-field nanophotonics based on polycrystalline nano-films.
Components of Oranta-AO software expert system for innovative application of blood pressure monitors
Authors: Vakulenko Dmytro , Vakulenko Lyudmyla , Zaspa Hryhoriy , Lupenko Serhii , Stetsyuk Petro , Stovba Viktor 
Published: August 2022

Abstract
The authors developed and substantiated the original methods of arterial oscillography, which were implemented in the developed Oranta-AO information system. The methods application to the arterial oscillogram registered at measurement of arterial pressure gives the possibility to carry out the supplementary systematic assessment of health, functional state of cardiovascular system, its reserve possibilities etc. The authors also developed an Expert System (based on machine learning methods) for the differential diagnosis of risks of heart, lung, mental illness and prognosis of some blood parameters. Oranta-AO software system was created based on research results due to methods and algorithms that were innovate. For the mathematical modeling of arterial oscillograms used cyclic random processes. Methods of arterial oscillograms processing based on its model in the form of a cyclic random process was developed. The method of evaluation of the rhythm function of arterial oscillograms and statistical methods for estimating the probabilistic characteristics of arterial oscillograms were developed. To solve the clustering problem, the Python k-means and k-means + + algorithm were used. Oranta-AO information system consists of three interrelated parts: mobile application, computing kernel and web system. Computing kernel and web system are deployed on AWS servers and have been tested already. The developed environment aims to be integrated into every new model of electronic meters in the world. Certification (EN 62304:2014, ISO 13485: 2018) in Ukraine is completed, PCT priority is completed. The next step will be to establish cooperation with manufacturers of electronic pressure monitors, patenting and certification in world.
Activation maps of convolutional neural networks as a tool for brain degeneration tracking in early diagnosis of dementia in Parkinson's disease based on magnetic resonance imaging
Authors: Suwalska Aleksandra , Siuda Joanna , Kocot Szymon , Zmuda Weronika , Rudzinska-Bar Monika , Polanska Joanna 
Published: August 2022

Abstract
Identification of Parkinson's Disease (PD) patients at risk for development of dementia is crucial for early intervention. However, diagnosing dementia in PD patients requires advanced, time-consuming and expensive imaging techniques (such as DaT-SCAN-SPECT). The study aims to prove the usefulness of convolutional neural networks (CNN) for the identification of brain areas related to the progress of cognitive impairment by using standard Magnetic Resonance Imaging (MRI) sequences. T1&T2 sequences of 18 patients were used in the pilot study. Activation maps were generated, and the brain regions most involved in the classification process were identified, showing areas potentially significant in the diagnosis of cognitive impairment severity. The cerebellum was proven significant for distinguishing the above-mentioned classes in relative cerebellum volume (ANOVA p-value=0.0038 with large effect size η2=0.5254) and folding (p-value=0.0031, η2=0.5357), which is consistent with reports by other authors. Our analysis demonstrates that convolutional neural networks combined with a proper image preprocessing pipeline could be used for feature extraction in MRI sequences and can successfully support the identification of disease-specific abnormalities of the brain image.
The overestimation of concentric hypertrophy in patients with HFpEF as determined by 2D- echocardiography
Authors: Mathbout Mohammad F , Al Hennawi Hussam , Khedr Anwar , Vaidya Gaurang N , Stoddard Marcus 
Published: August 2022

Background: Heart failure with preserved ejection fraction continues to pose multiple challenges in terms of accurate diagnosis, treatment, and associated morbidity. Accurate left ventricular (LV) mass calculation yields essential prognostic information relating to structural heart disease. Two-dimensional (2D) echocardiography-based calculations are solely limited to LV geometric assumptions of symmetry, whereas three-dimensional (3D) echocardiography could overcome these limitations. This study aims to compare the performance of 2D and 3D LV mass calculations.Methods: A prospective review of echocardiography findings at the University of Louisville, Kentucky, was conducted and assessed. Normal ejection fraction (EF) was defined as >=52% in males and >=54% in females. The following calculations were performed: relative wall thickness (RWT) = 2x posterior wall thickness/LV internal diastolic dimension (LVIDd) and 2D LV mass = 0.8{1.04([LVIDd + IVSd +PWd]3 - LVIDd3)} + 0.6. Concentric hypertrophy was RWT > 0.42 and LV mass >95 kg/m2 in females or > 115 kg/m2 in males. The same cut-offs were used for 2D and 3D echocardiography.Results: Echocardiographic findings for a total number of 154 patients in the study were investigated. There was a weak positive correlation between 2D and 3D LV mass indices (R= 0.534, r2= 0.286, p= 0.001). Seventy patients had 3D EF >=45% with clinical heart failure (HFpEF). Among HFpEF patients, LV hypertrophy (LVH) was present in 74% of patients by 2D echocardiography and 30% by 3D echocardiography (McNemar test p= 0.001). Using 3D echocardiography as the reference, 68% of normal patients were misdiagnosed with LV hypertrophy by 2D echocardiography. Two-thirds of the patients with concentric remodeling by 3D echocardiography were misclassified as having concentric hypertrophy by 2D echocardiography (p=0.001).Conclusion: Adapting necropsy-proven LV mass index cutoffs, 2D over-diagnosed LV hypertrophy through overestimation of the mass, compared to 3D echocardiography. In turn, the majority of HFpEF patients showed no structural hypertrophy of the LV on 3D imaging. This suggests that the majority of patients with HFpEF may qualify for pharmacological prevention to prevent further progression to LV remodeling or LVH.
The undesirable communication: A case of cerebral air emboli in the setting of atrio- esophageal fistula following atrial fibrillation catheter ablation
Authors: Islam Momin , Al Hennawi Hussam , Khedr Anwar , Harmouch Khaled , Mathbout Mohammad F 
Published: August 2022

Atrial-esophageal fistula is an extremely rare condition but is often a deleterious complication following catheter ablation for atrial fibrillation. The associated iatrogenic communication acts as a conduit for air and bacterial translocation, which may lead to cerebral air embolism and polymicrobial sepsis, respectively. Coupled with a history of invasive procedures, the diagnosis is largely based on the accompanying neurological symptoms. In this report, we present the case of a 73-year-old female who presented with neurological deficits attributed to cerebral vascular emboli three weeks after catheter ablation for the treatment of chronic atrial fibrillation.
Branding fashion muslim (studi analisis brand wearing klamby)
Authors: Fitri Alifa Nur , Fabriar Silvia Riskha , Hilmi Mustofa 
Published: August 2022

The halal industry in Indonesia is undergoing development. This is supported by 87.17% of Indonesia's population are Muslims. One of the growing industries is the Muslim clothing industry. Modest fashion, a term for fashion trends with a more polite and closed fashion concept. One of the famous Muslim fashions is Wearing Klamby. A local fashion brand from Yogyakarta whose collections have local content. This paper aims to see how Muslim fashion branding is used by Wearing Klamby. During of competition in the Muslim fashion business, branding is an important thing as a form of differentiation with other products, Brand can give life to a product. Branding Wearing Klamby as a product that loves the country is shown with the tagline " The Beauty Indonesia in your daily wear". WearingKlamby is one of the strong fashion products in its Branding. This paper uses a qualitative method with descriptive type with analytic using 7 principles of Fashion Branding according to Bruno Hasson. The data was obtained from social media and news. The results of this paper show that Klamby uses 7 principles of Fashion Branding Bruno Hasson in forming Muslim fashionbranding Wearing Klamby including creating a logo that Stands Out, Building Myths about Brands, Creating evocative Events, using celebrity endorsers, making members as living brand, and do it your way. The existence of the brand can form brand loyalty to consumers Wearing Klamby.
Islam wasathiyah value in photojournalism in Guo Ji Ri Bao newspaper
Authors: Rahmayuni Dewi , Setiawan Arief Tri , Bakti Andi Faisal 
Published: August 2022

Photojournalism is one of the various channels to convey messages in visual form. It is a combination of images and texts that produces a single communication unit that reflects events and issues in a society. In the A8 section of Guo Ji Ri Bao, a Mandarin-language newspaper in Indonesia, dated September 25, 2020, seven photojournalism materials were discovered to contain signs and symbols related to Islam Wasathiyah value. This implied message indicated the media’s “agenda” in presenting reality or social issues, where the agenda typically corresponds to the ideology of the media itself. The media construct the frame of mind for their readers even with symbols and this study originated with the formulation of the main problem: “How is the value of Islam wasathiyah reflected in photojournalism on the Guo Ji Ri Bao newspaper viewed from the perspective of meanings and media?” An analysis of semiotics, structuralism, connotation and denotation based on Gill Branston and Roy Stafford's Meanings and Media perspective were utilized in this study. It was discovered that Guo Ji Ri Bao newspaper played a significant role in conveying the value of Islam Wasathiyah. This value is important to convey to all levels of society even through photos because it will be one of the ways to preach (da’wah) that lead us to a happy, peaceful, and harmonious life.***Foto jurnalistik merupakan salah satu saluran penyampai pesan dalam bentuk visual. Foto jurnalistik terbentuk sebagai kombinasi dari gambar dan teks yang menghasilkan satu kesatuan komunikasi yang mencerminkan makna tersendiri dan permasalahan dalam masyarakat. Pada media Guo Ji Ri Bao surat kabar berbahasa Mandarin di Indonesia, pada rubrik A8 25 September 2020, ditemukan tujuh materi foto jurnalistik yang memuat tanda dan simbol terkait nilai Islam wasathiyah. Pesan yang tersirat ini berkaitan dengan “agenda” media dalam menyajikan realitas atau isu-isu sosial yang terjadi. Agenda sebuah media erat kaitannya dengan ideologi media itu sendiri. Sehingga, media kerap mengkonstruksi bingkai pemikiran pembacanya bahkan dengan unsur simbol dan tanda sekalipun. Studi ini hadir dengan rumusan masalah utama: “Bagaimana nilai Islam wasathiyah dalam foto jurnalistik pada surat kabar Guo Ji Ri Bao dalam perspektif meanings and media, dengan fokus menggali aspek semiotika, strukturalisme, dan makna konotasi dan denotasi berdasarkan perspektif makna dan media karya Gill Branston dan Roy Stafford. Kesimpulan pada penelitian menyatakan bahwa surat kabar Guo Ji Ri Bao memainkan peran penting dalam menyampaikan nilai-nilai Islam wasathiyah. Nilai ini penting untuk disampaikan kepada seluruh lapisan masyarakat bahkan melalui foto karena akan menjadi salah satu corong dakwah untuk mengantarkan kita pada tatanan kehidupan yang aman, damai, tenteram, dan bahagia.
Strategi komunikasi media Islam alif.id dan ibtimes.id dalam penyebaran paham moderasi
Authors: Aprilyawati Firda Dwi , Nurudin Nurudin 
Published: August 2022

This study aims to know the media communication strategies of Alif.id and IBTimes.id as website media with a moderate Islamic background. The approach adopted in this study is a descriptive qualitative approach. The results of this study indicated that the strategies used by the media Alif.id and IBTimes.id are the strengthening of the character and the branding of each media by using a cultural approach. Thus, Alif.id and IBTimes.id are also consistent in maintaining the quality of the Islamic missionary (da'wah) content presented through articles and readings. In addition, the publication through social media becomes an important strategy because it is able to reach a broad and fast target audience. Again, the presentation of variations in content such as events, presentations, news, and inspirational videos can also increase engagement and awareness of target audience. As an implication, this study recommends the necessity of using media in an effort to spread the values of religious moderation in the midst of a lot of counter-productive content with universal religious spirit.***Tujuan dari studi ini adalah untuk mengetahui strategi komunikasi media Alif.id dan IBTimes.id sebagai media Islam moderat. Studi ini menggunakan pendekatan kualitatif dengan metode deskriptif. Studi menunjukkan hasil bahwa strategi yang digunakan oleh media Alif.id dan IBTimes.id, yaitu penguatan karakter dan branding media masing-masing dengan menggunakan pendekatan secara kultural. Alif.id dan IBTimes.id konsisten dalam menjaga kualitas muatan dakwah yang disajikan melalui artikel dan bacaan. Publikasi melalui media sosial menjadi strategi yang penting karena mampu menyentuh target khalayak secara luas dan cepat. Selain itu, penyajian variasi konten seperti event, sajian, berita, video inspiratif juga mampu meningkatkan ketertarikan dan keterikatan target audience. Sebagai implikasinya, studi ini menganjurkan keharusan penggunaan media dalam upaya menyebarkan nilai-nilai moderasi beragama di tengah banyaknya konten yang kontra-produktif dengan semangat keagamaan universal.
Calcium chloride enhances growth and physio-biochemical performance of barley (Hordeum vulgareL.) under drought-induced stress regimes: a future perspective of climate change in the region
Authors: Shah Wadood , Zaman Noor , Ullah Sami , Nafees Muhammad 
Published: August 2022

AbstractWater is the fundamental part of living systems and it plays a key role in supporting life on earth; however, fluctuations in climatic conditions lead to limitation of the ground water causing serious concerns. The present research study was aimed at assessing growth and physio-biochemical responses of barley to calcium chloride (CaCl2) solution (10 mM) applied through roots under induced drought stress for 5, 10, and 15 days. CaCl2, being an enhancer of osmolytes and antioxidant enzymes, counteracts the damaging effects caused by abiotic stresses. A pot experiment was conducted by sowing barley under induced drought stress for 5, 10, and 15 days, respectively. Plants exposed to different levels of the induced drought stress condition were treated with 10 mM of CaCl2 solution via roots during the seedling stage. Results indicated that water-limited conditions negatively affected plant growth parameters including final emergence percentage, final germination percentage, and mean emergence time. Moreover, absolute growth rate, relative growth rate, and net assimilation rate were significantly improved under 5, 10, and 15 days of drought stress supplemented with CaCl2 solution. Under drought conditions, an increase was observed in hydrogen peroxide (H2O2), glycine betaine (GB), and proline (PRO) content, and in ascorbate peroxidase (APX), catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), and lipid peroxide (LPO) activities. H2O2 and LPO showed a significant decline with CaCl2 application under induced drought stress regimes. On the contrary, GB, PRO, APX, CAT, POD, and SOD contents of root and leaf were significantly improved with CaCl2 application under induced drought stress. In conclusion, CaCl2 solution effectively curbed the damages caused by oxidative stress via accumulating osmolytes and scavenging reactive oxygen species by activating the antioxidant enzymatic defence system of barley.
Assessing the performance of SN-SPI and SPI and the trend assessment of drought using the XI correlation technique over Iran
Authors: Ghasemi Mohammad Mehdi , Mokarram Marzieh , Zarei Abdol Rassoul 
Published: August 2022

Abstract
In recent decades, human activities such as the excessive production of carbon dioxide gas, deforestation, overexploitation of natural resources, and so on have caused changes in the climate regimes and frequent occurrence of droughts. Thus, the investigation of the trend of changes in drought can be effective in better understanding the drought condition and also more properly managing the adverse effects of drought. Therefore, in this study, the trend of changes in drought was assessed based on the standardized precipitation index (SPI) and the spatially normalized SPI (SN-SPI) in 34 stations over Iran on 1-, 3-, 6-, and 12-month time scales from 1967 to 2019 using the XI correlation technique (XICOR). Then, using the mean residual error (MRE) index and also a comparison of the correlation coefficient (CC) between the SPI and SN-SPI values with a perfect reliable line (line with the equation Y=X- or T-Statistics index), the performances of the SPI and SN-SPI were investigated. The results of the trend assessment indicated that the SPI and SN-SPI had almost the same performance in all chosen time scales (including 1-, 3-, 6-, and 12-month). However, the results of the T- Statistics and MRE revealed that the calculated values of the SN-SPI in more than 80% of the chosen stations (in the selected time scales) were different from the SPI, and in more than 70% of stations, the calculated values of the SN-SPI were less than the SPI. Therefore, it can be said that the SN-SPI has a different performance from the SPI, and under the influence of spatial normalization of the precipitation values in the SN-SPI, the overall level of the calculated SN-SPI values will be decreased.