bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing traumatic brain injury screening in behavioral healthcare: protocol for a prospective mixed methods study
Authors: Coxe-Hyzak Kathryn A. , Bunger Alicia C. , Bogner Jennifer , Davis Alan K. , Corrigan John D. 
Published: February 2022

Abstract
Background
Characteristics of both individuals and innovations are foundational determinants to the adoption of evidenced-based practices (EBPs). However, our understanding about what drives EBP adoption is limited by few studies examining relationships among implementation determinants and implementation outcomes through theory-driven hypothesis testing. Therefore, drawing on the Theory of Planned Behavior and Diffusion of Innovations Theory, this study will disentangle relationships between provider characteristics and innovation factors on the early adoption of the Ohio State University Traumatic Brain Injury Identification Method (OSU TBI-ID) in behavioral health settings.

Methods
This study will utilize an explanatory sequential mixed methods design. In Phase I (quantitative), Time 1, we will investigate behavioral health providers (N = 200) attitudes, perceived behavioral control, subjective norms, and intentions to screen for TBI upon completion of a video module introducing the OSU TBI-ID. At Time 2, we will examine the number of TBI screens conducted over the previous month, as well as the feasibility, appropriateness, and acceptability of using the OSU TBI-ID in practice. Structural equation modeling will be used to determine whether provider characteristics predict TBI screening intentions, and whether intentions mediate actual TBI screening behaviors. We will then test whether feasibility, appropriateness, and acceptability of the OSU TBI-ID moderates the relationship between intentions and TBI screening behaviors. In Phase II (qualitative), we will develop an interview guide using results from Phase I and will conduct semi-structured interviews with providers (N = 20) to assess contextual determinants of TBI screening adoption. Qualitative data will be thematically analyzed using sensitizing concepts from the Consolidated Framework for Implementation Research and integrated with the quantitative results using a joint display.

Discussion
This mixed methods study capitalizes on two theory-driven hypotheses bridging proximal (e.g., screening intent) to distal (actual behaviors) implementation outcomes and will contextualize these results qualitatively to advance our understanding about why TBI screening adoption has failed to translate to the behavioral healthcare context. Results of this study will offer insights into what is driving TBI screening adoption so that implementation strategies can be selected with greater precision to improve the adoption, sustainment, and scale-up of TBI screening in behavioral healthcare.
Molecular basis of AR and STK11 genes associated pathogenesis via AMPK pathway and adipocytokine signalling pathway in the development of metabolic disorders in PCOS women
Authors: Gollapalli Pavan , Kumari N. Suchetha , Shetty Praveenkumar , Gnanasekaran Tamizh Selvan 
Published: February 2022

Abstract
Background
One of the most common hormonal disorders in women of reproductive age is polycystic ovary syndrome (PCOS). In recent years, it has been found that insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes mellitus. To explore the differentially expressed genes (DEGs) that regulate these kinds of metabolic risks in PCOS women, we chose the gene expression profile of GSE8157 from the gene expression omnibus (GEO) database.

Results
Using the GEO2R tool, we identified a total of 339 DEGs between the case and the control sample groups. Gene ontology and Kyoto encyclopedia of gene and genome pathway enrichment analysis were subsequently conducted. High connectivity, betweenness centrality, bottleneck centrality, closeness centrality, and radiality measures were used to rank the ten hub genes. Furthermore, the overlap of these genes resulted in the development of two key genes, AR and STK11. The AMPK and adipocytokine signaling pathways are the two main pathways that these DEGs are involved.

Conclusions
The backbone genes, hub genes and pathways identified would assist us in further exploring the molecular basis of developing risk of type 2 diabetes mellitus in PCOS women and thus provide diagnostic or therapeutic clues.
A full CIRCLE: inclusion of autistic doctors in the Royal College Of Psychiatrists’ values and Equality Action Plan
Authors: McCowan Sue , Shaw Sebastian C. K. , Doherty Mary , Grosjean Bernadette , Blank Paula , Kinnear Malcolm 
Published: February 2022

SummaryAutistic psychiatrists bring strengths and values to the workforce and ask to be acknowledged and supported as part of the Royal College of Psychiatrists’ CIRCLE values and Equality Action Plan. Courage and collaboration are required to jointly learn and innovate, promoting well-being, resilience and excellence for autistic doctors.
Patient's Perspective on the Impact of COVID-19 on Cancer Treatment in Nigeria
Authors: Joseph Adedayo , Olatosi Bankole , Haider Mohammad Rifat , Adegboyega Bolanle C. , Lasebikan Nwamaka N. , Aliyu Usman M. , Ali-Gombe Musa , Jimoh Mutiu A. , Biyi-Olutunde Olusegun Abayomi , Awofeso Opeyemi , Fatiregun Omolara Aminat , Oboh Evaristus Oseiwe , Nwachukwu Emmanuella , Zubairu Ismail H. , Otene Samuel A. , Iyare Oluwatoyin I. , Andero Temitope , Musbau Alabi Babatunde , Ajose Azeezat , Onitilo Adedayo A. 
Published: February 2022

PURPOSE Because of the global COVID-19 pandemic, health care organizations introduced guidelines for modifications to health and cancer medical care delivery to mitigate transmission and ensure quality health outcomes. To examine the extent and impact of these modifications on oncology service disruptions in Nigeria, we surveyed oncology patients across selected public and private cancer treatment centers. MATERIALS AND METHODS Participating in the study were 15 tertiary cancer treatment centers across 12 Nigerian states. We recruited adult patients with cancer (18+ years) on active treatment to complete a self-administered survey on cancer care during COVID-19. We conducted descriptive and multivariate data analysis using Stata 16.1. RESULTS Respondents were (n = 1,072), female (65.7%), ages 18-49 years (50.3%), and married (80.7%). The top two cancers were breast and prostate. Overall, 17.3% of respondents reported disruptions to cancer care, and more than half (51.0%) reported difficulties accessing care. Changes in chemotherapy regimens or route of administration were reported in 8.4% of respondents. Odds for any disruption were highest for older patients, western states, patients with prostate cancer, and patients with two or more flu symptoms. Odds for radiotherapy cancellation were highest for older patients, those with prostate cancer, and those with medium service perception. CONCLUSION This study investigated COVID-19–influenced cancer treatment disruptions in Nigeria. Patients with cancer experienced significant disruptions to cancer care. Vulnerable patients are most likely to be negatively affected. Policies and strategies aimed at minimizing service disruptions while maintaining cancer patients' safety should be a priority for all health care institutions in the COVID-19 era.
Establishing Synoptic Cancer Pathology Reporting in Low- and Middle-Income Countries: A Nicaraguan Experience
Authors: Valverde L Darling , Reznichek Richard C. , Torres S Magdaly 
Published: February 2022

PURPOSE Cancer pathology reports have traditionally been narrative with limited reliable information. In high-income countries, synoptic format reporting has gradually been introduced to improve patient care and cancer registry input. We posited that introduction of synoptic style reporting was possible in Nicaragua and could serve as a model for other low- and middle-income countries. MATERIALS AND METHODS The Department of Pathology, Hospital Escuela Oscar Danilo Rosales Argüello (HEODRA), León, Nicaragua, decided to introduce and implement synoptic reporting for all cancer cases beginning in 2018. All 10,012 histopathologic case reports issued by the department from January 1, 2018, through June 30, 2020, were reviewed. After excluding benign lesions, recurrent or metastatic tumors, endometrial biopsies or curettage, and primary cytologic specimens, 724 cases met the criteria for synoptic style reporting. The narrative format, previously used for all cases, was intentionally abandoned. RESULTS Of the 10,012 reports reviewed at HEODRA during the study period, synoptic-style reporting was used for all 724 cancer cases that met criteria for inclusion in the study. In addition, all elements were listed in the required order. Narrative format of reporting was not used for any of the reports. CONCLUSION Our experience in Nicaragua has shown that establishing synoptic-style cancer pathology reporting is achievable in a low- or middle-income country. Just as in high-income countries, a dedicated collaborative step-by-step conversion to synoptic reporting can lead to improvement in cancer patient care and quality of data for population-based registries.
A Novel Mobile Device-Based Navigation System for Placement of Posterior Spinal Fixation
Authors: Driver Joseph , Dorman John K. , Chi John H. 
Published: February 2022

BACKGROUND:
Spinal navigation technology has revolutionized the field of spine surgery. However, adoption has not been universal. Reasons include cost, interruption in surgical workflow, increased OR time, and potential implant incompatibility, among others. A technology that maintains performance but alleviates these drawbacks would be valuable. A mobile device-based navigation system has been developed which relies on the iOS platform and the gyroscopic-on-chip technology, therein to guide accurate placement of pedicle screws. This system maintains a minimal footprint and resolves difficulty with line-of-sight interruption and attention shift.

OBJECTIVE:
To evaluate the accuracy and reliability of this device in a preclinical setting.

METHODS:
A cadaver study was performed involving 13 surgeons placing 26 pedicle screws using the novel assistive technology. CT scans were then performed, and accuracy was assessed by designating each screw a Gertzbein–Robbins score. In addition, bench top table testing was performed. This consisted of 360 tests of both the accuracy of the device's pitch and roll, corresponding to the rotation about the device's x-axis and y-axis, respectively.

RESULTS:
The mean Gertzbein–Robbins score of the 26 screws placed in the cadaver study was 1.29. The mean deviation from centerline pedicle placement was 0.66 mm, with a standard deviation of 1.52 mm. The bench top study results included a mean pitch error of 0.17° + 0.09° and a mean roll error of 0.29 + 0.21.

CONCLUSION:
The novel mobile device-based navigation system for placement of pedicle screws presented here demonstrates high levels of accuracy and reliability in the preclinical setting.
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum
Authors: Su Zihao , Wang Ziwu , Lindtner Susan , Yang Lin , Shang Zicong , Tian Yu , Guo Rongliang , You Yan , Zhou Wenhao , Rubenstein John L. , Yang Zhengang , Zhang Zhuangzhi 
Published: February 2022

ABSTRACT
The striatum is a central regulator of behavior and motor function through the actions of D1 and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic eminence (LGE) progenitor. The molecular mechanisms of cell fate specification of these two neuronal subtypes are incompletely understood. Here, we found that deletion of murine Meis2, which is highly expressed in the LGE and derivatives, led to a large reduction in striatal MSNs due to a block in their differentiation. Meis2 directly binds to the Zfp503 and Six3 promoters and is required for their expression and specification of D1 and D2 MSNs, respectively. Finally, Meis2 expression is regulated by Dlx1/2 at least partially through the enhancer hs599 in the LGE subventricular zone. Overall, our findings define a pathway in the LGE whereby Dlx1/2 drives expression of Meis2, which subsequently promotes the fate determination of striatal D1 and D2 MSNs via Zfp503 and Six3.
Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis
Authors: Gandara Ana Caroline P. , Drummond-Barbosa Daniela 
Published: February 2022

ABSTRACT
Despite their medical and economic relevance, it remains largely unknown how suboptimal temperatures affect adult insect reproduction. Here, we report an in-depth analysis of how chronic adult exposure to suboptimal temperatures affects oogenesis using the model insect Drosophila melanogaster. In adult females maintained at 18°C (cold) or 29°C (warm), relative to females at the 25°C control temperature, egg production was reduced through distinct cellular mechanisms. Chronic 18°C exposure improved germline stem cell maintenance, survival of early germline cysts and oocyte quality, but reduced follicle growth with no obvious effect on vitellogenesis. By contrast, in females at 29°C, germline stem cell numbers and follicle growth were similar to those at 25°C, while early germline cyst death and degeneration of vitellogenic follicles were markedly increased and oocyte quality plummeted over time. Finally, we also show that these effects are largely independent of diet, male factors or canonical temperature sensors. These findings are relevant not only to cold-blooded organisms, which have limited thermoregulation, but also potentially to warm-blooded organisms, which are susceptible to hypothermia, heatstroke and fever.
Chickens have excellent sound localization ability
Authors: Krumm Bianca , Klump Georg M. , Köppl Christine , Beutelmann Rainer , Langemann Ulrike 
Published: February 2022

ABSTRACT
The mechanisms of sound localization are actively debated, especially which cues are predominately used and why. Our study provides behavioural data in chickens (Gallus gallus) and relates these to estimates of the perceived physical cues. Sound localization acuity was quantified as the minimum audible angle (MAA) in azimuth. Pure-tone MAA was 12.3, 9.3, 8.9 and 14.5 deg for frequencies of 500, 1000, 2000 and 4000 Hz, respectively. Broadband-noise MAA was 12.2 deg, which indicates excellent behavioural acuity. We determined ‘external cues’ from head-related transfer functions of chickens. These were used to derive ‘internal cues’, taking into account published data on the effect of the coupled middle ears. Our estimates of the internal cues indicate that chickens likely relied on interaural time difference cues alone at low frequencies of 500 and 1000 Hz, whereas at 2000 and 4000 Hz, interaural level differences may be the dominant cue.
The benefit of tissue sealant on urethroplasty in hypospadias patients – A systematic review and meta-analysis
Authors: Siregar Safendra , Steven Steven , Mustafa Akhmad 
Published: February 2022

Background: Hypospadias was ranked second after undescended testis as the most prevalent congenital abnormality in newborn males. Hypospadias can be successfully repaired through multiple surgeries in the majority of children. Postoperative complications were not rarely seen after surgeries, such as urethrocutaneous fistula (UCF), meatal stenosis, and glans breakdown. Tissue sealant application in hypospadias repair serves as additional suture line coverage and reduces the post surgery complications5.However, the effects of sealants usage during urethroplasty are still uncertain. This review aimed to know the effects of tissue sealant usage on patients with hypospadias who undergo urethroplasty. Methods: The study was reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Literature was searched on PubMed, Embase, and Scopus following PRISMA guidelines. The search was conducted on October 12th, 2021, using the search term ("glue" OR "sealants" OR "tissue glue" OR "tissue sealant" OR "tissue adhesive") AND ("hypospadias" OR "urethrocutaneous fistula" OR "urethral repair" OR "urethroplasty" OR "hypospadiology"). Result: Systematic searching from all databases resulted in 160 potential articles. After a full-text review, eight articles were included in this study. UCF complication was reported in all studies. The occurrence of complication reported by all studies was urethrocutaneous fistula. Several studies also reported tissue edema and flap-related complications. Tissue sealant had no significant effect in reducing meatal stenosis. Conclusions: This systematic review revealed additional benefits from several types of tissue sealant in hypospadias repair surgery. Fibrin sealant application over the urethroplasty suture line in hypospadias repair offers a water-proof coverage and may enhance the outcome from the surgery.
Framing and understanding the whole aspect of oral sex from social and health perspective: a narrative review
Authors: Pakpahan Cennikon , Darmadi Darmadi , Agustinus Agustinus , Rezano Andri 
Published: February 2022

Since thousands of years ago, oral sex has become part of sexual behavior among humans. Oral sex is considered taboo. Its taboo does not lie in the behavior, but its expression is deemed inappropriate. As technology becomes more sophisticated, human rights also stand out, leading to the disclosure of the practice in the 21st century. The oral sex that is discussed on a large scale in media encourages people to express it as feedback whether within right or not. It all depends on the value of each people. We found that this sexual behavior is found everywhere regardless of religion, culture, and race. Pop culture influences this behavior so much, it can be seen from music, movies, and television programs that provoke oral sex. Many motivations underlying this behavior include getting sexual pleasure for the sake of living well-being. But it is undeniable that this behavior is still controversial. It could be at risk of causing disease and, on the other hand, is reported to provide many benefits. According to our theory, oral sex is not a new behavior crossing boundaries. It is just an old behavior that surfaces because of the factors that support it. This behavior, which is still considered taboo, has its disadvantages such as sexually transmitted disease but has also benefits such as preventing preeclampsia.
Sustainability of mangrove forest management in the former bauxite mining area on Bintan Island
Authors: Azizah Diana , Hamidy Rasoel , Mubarak . , Efriyeldi . , Said Raza’i Tengku , Muzammil Wahyu , Pardi Hilfi 
Published: February 2022

Background : The bauxite mining area on Bintan Island continues to expand into the mangrove forest area. Mangrove forests have ecological, economic, and social importance, which must be managed accordingly to maintain their sustainability. This research was conducted to examine the sustainability of mangrove forest management in the former bauxite mining area on Bintan Island. Methods: The approach used is Multi Dimensional Scaling- Rapid Appraisal for Sustainability through the modified Rapfish ordinance software technique for the Mangrove Ecosystem. The type of data used is quantitative, covering five dimensions of sustainability, namely ecological, economic, social, legal and institutional as well as technology. Results: The results showed that the sustainability index status of the ecological, social, legal and institutional dimensions was quite sustainable, while the sustainability index of the economic dimension was unsustainable, and the technological dimension was less sustainable. Attributes of levers that are sensitive to the sustainability of mangrove forest management are: 1) Mangrove density, 2) Substrate fraction, 3) sedimentation, 4) Mangrove importance index, 5) Bio-concentration factor, 6) Benefit value direct, 7) Indirect benefit value, 8) Dependence on mangrove forest as a source of livelihood, 9) Corporate Social Responsibility funding support, 10) Community income, 11) Community health level, 12) Community perception, 13) Legality of mangrove area and mining, 14) Pollution monitoring technology in ex-mining areas and 15) Mangrove rehabilitation technology. Conclusions:The status of the mangrove forest sustainability index on Bintan Island is quite good. the economic and technological dimensions can be upgraded to sustainable status by carrying out management that is more focused on the lever attributes of the ecological, social, legal and institutional dimensions.
Association of women’s literacy and children’s mortality rate among countries in southeast Asia 2015-2019: a cross-sectional study
Authors: Satria Fauzi Budi , Lubis Rahayu , Hsu Yi-Hsin Elsa , Iqbal Usman 
Published: February 2022

Background: Women’s literacy is often associated with the health status of family members, especially children. Unfortunately, in some regions of Southeast Asia, the rates of women’s literacy are still very low, and in these areas, children’s mortality rates are also very high. This study aims to identify the association of women's literacy and children’s mortality rates among countries in the Southeast Asian region from 2015 to 2019. Methods: In this cross-sectional study, children’s mortality rates were defined as mortality rates in newborns and under-fives. Besides women’s literacy (WL), we also assessed the Human Development Index (HDI), Freedom Status (FS), Government Effectiveness (GE), and the proportion of births assisted by skilled health staff (BASHS) as the independent variables in this study. First, we describe the profiles of WL as well as newborn and under-five mortality rates among 11 countries in Southeast Asia from 2015 to 2019, and then we assess the correlations. Results: Between 2015 to 2019, Myanmar, Lao, and Timor-Leste had the highest child mortality rates. In addition, these four countries were the countries with the lowest WL rates compared to other countries. Children’s mortality rates were significantly associated with WL, GE, HDI, and BASHS. Meanwhile, this study found that the FS of a country was not significantly associated with the children’s mortality rate of countries in the Southeast Asia region. Conclusion: This study found that there’s an indication that the better the WL rate, as well as the governance, the HDI, and maternity services in a country, the lower its children’s mortality rates. Therefore, improvement in multiple sectors such as governance, economy, health system, education, and gender equality is required to help countries in this region achieve the United Nations’ Sustainable Development Goals target by 2030.
A survey of innovation management among persons with disabilities in Malaysia
Authors: Yee Yen Yuen , Wu Jian Yong Eddie , Teoh Ming Yen Wendy 
Published: February 2022

Background: As Malaysia struggles with the battle to retain talented workers, the retention of persons with disabilities (PWDs) remains a major challenge in innovation management. Malaysia currently has the lowest retention of PWDs in innovation management in The Association of Southeast Asian Nations (ASEAN). The purpose of this study is to develop a unique framework to enhance the inclusion of PWDs in Malaysia. Methods: A questionnaire was distributed to 200 PWDs in the central region of Malaysia. Results: Based on the results of this research, four crucial variables (salary, compensation, career advancement and reward management) contributed to the lack of involvement in innovation management among PWDs in Malaysia. Conclusions: This study only focuses on 200 PWDs in Malaysia. Despite the fact that PWDs’ involvement in innovation management is the lowest, there is a lack of research initiative and practitioner commitment to address this issue. Serving as preliminary research in Malaysia, this study develops a unique framework to fill the gap.