bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Baby brain’ in pregnancy: A review of social psychological explanations and future research directions
Authors: Pownall Madeleine , Conner Mark , Hutter Russell R. C. 
Published: June 2022

AbstractThe colloquial concept of ‘baby brain’ suggests that throughout pregnancy and into the immediate postpartum period, women have reduced cognitive abilities and are more distracted, forgetful, and incompetent. To date, a plethora of cognitive and neuropsychological research testing the cognitive functioning of pregnant women relative to other groups has yielded inconsistent and unclear findings. However, there is a notable lack of literature that adopts a social psychological perspective, critically assessing the contribution of social context to the ‘baby brain’ phenomenon. In this paper, we review the current ‘baby brain’ literature and outline two potential social perspectives that provide insights into this research area: stereotype threat theory and objectification theory. We argue that inconsistencies in the ‘baby brain’ cognitive literature may be impacted by under‐explored social phenomena, which may result from activation of stereotypes or objectifying cues throughout pregnancy and into early new motherhood. We end with suggestions for future social and personality psychological research directions in the area of ‘baby brain’.
Evaluation of clotrimazole prophylaxis on tacrolimus trough concentrations in kidney transplant recipients
Authors: Wings Emily , Spinner Michael , Eckardt Jamie 
Published: June 2022

AbstractBackgroundClotrimazole troches are used as prophylaxis against oropharyngeal candidiasis post‐transplant and have limited systemic absorption. Following several occurrences of tacrolimus concentration fluctuations after clotrimazole discontinuation, its use as prophylaxis was discontinued post‐kidney transplant.MethodsWe conducted a retrospective cohort study to evaluate the effect of clotrimazole prophylaxis on tacrolimus trough concentrations post‐kidney transplant. The study included adult patients who received a kidney transplant at Cleveland Clinic Main Campus from August 1, 2019 to July 1, 2020 and were maintained on per‐protocol, standard‐dose tacrolimus through 90 days post‐transplant. Patients were excluded if they received cyclosporine, systemic antifungals, strong CYP3A4 inhibitors or inducers, or a simultaneous multiorgan transplant. The primary objective was to compare tacrolimus trough concentrations before and after completion of clotrimazole prophylaxis. Secondary objectives were to compare the time to first post‐transplant goal tacrolimus trough concentration, the rate of for‐cause allograft biopsies within 90 days after transplant, and the incidence and type of candidiasis within 30 days after transplant, pre‐ and post‐protocol change.ResultsFollowing clotrimazole discontinuation, the median tacrolimus trough concentration decreased from 10.5 ng/ml (IQR 8.4–12.2) to 6.6 ng/ml (IQR 5–8.7, p < 0.0001). No statistically significant differences in the rate of for‐cause allograft biopsies (4.9% vs. 9.7%, p = 0.264) or incidence of candidiasis (1.2% vs. 5.4%, p = 0.217) were observed between those who received clotrimazole and those who did not receive clotrimazole.ConclusionsOur study provides further evidence of a significant drug–drug interaction between tacrolimus and clotrimazole among kidney transplant recipients that can potentially lead to negative allograft outcomes.
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Maternal and foetal‐neonatal outcomes of dengue virus infection during pregnancy
Authors: Rathore Sawai Singh , Oberoi Sharvi , Hilliard Jonathan , Raja Ritesh , Ahmed Noman Khurshid , Vishwakarma Yogesh , Iqbal Kinza , Kumari Chandani , Velasquez‐Botero Felipe , Nieto‐Salazar María Alejandra , Cortes Guillermo Andrés Moreno , Akomaning Edwin , Musa Islam elFatih Mohamed 
Published: June 2022

AbstractObjectiveGiven that women of reproductive age in dengue‐endemic areas are at risk of infection, it is necessary to determine whether dengue virus (DENV) infection during pregnancy is associated with adverse outcomes. The aim of this systematic review and meta‐analysis is to investigate the consequences of DENV infection in pregnancy on various maternal and foetal‐neonatal outcomes.MethodsA systematic literature search was undertaken using PubMed, Google Scholar, and Embase till December 2021. Mantel–Haenszel risk ratios were calculated to report overall effect size using random effect models. The pooled prevalence was computed using the random effect model. All statistical analyses were performed on MedCalc Software.ResultWe obtained data from 36 studies involving 39,632 DENV‐infected pregnant women. DENV infection in pregnancy was associated with an increased risk of maternal mortality (OR = 4.14 [95% CI, 1.17–14.73]), stillbirth (OR = 2.71 [95% CI, 1.44–5.10]), and neonatal deaths (OR = 3.03 [95% CI, 1.17–7.83]) compared with pregnant women without DENV infection. There was no significant statistical association established between maternal DENV infection and the outcomes of preterm birth, maternal bleeding, low birth weight in neonates, and risk of miscarriage. Pooled prevalences were 14.9% for dengue shock syndrome, 14% for preterm birth, 13.8% for maternal bleeding, 10.1% for low birth weight, 6% for miscarriages, and 5.6% for stillbirth.ConclusionDENV infection in pregnant women may be associated with adverse outcomes such as maternal mortality, stillbirth, and neonatal mortality. Hence, pregnant women should be considered an at‐risk population for dengue management programmes.
Place dialogue
Authors: Adams Paul C. , Kotus Jacek 
Published: June 2022

AbstractThis paper argues for attention to place dialogue, rethinking how place meanings emerge through interactions between human agency and the nonhuman agency of place. To speak is to act, so what is in play here is acknowledging place not only as a ‘speaker’ and a ‘listener’ but also as an agent. In addition to developing posthumanist geographies, the article proposes a new direction for geographical studies of communication, building on the semiotic theory of C.S. Peirce and closely related research in philosophical pragmatism. Communication geography research on place‐in‐communication (representations) and communication‐in‐place (infrastructures) should be complemented by a third approach that recognises place as an interlocutor intervening in meaningful ways with human and nonhuman inhabitants' lives. In calling for this sort of recognition of place dialogue, we trace an ontological shift already prescribed by Indigenous geography, assemblage theory, philosophical pragmatism and posthumanism. The body of the article offers glimpses of three place dialogues: a research meeting taking place in an outdoor seating area of a bakery/cafe, a short viral video featuring a resourceful rat living in the New York subway, and a trip to a nature preserve to climb a mountain. In each example, we show how geographers can return to the non‐modern idea that place acts and speaks.
Green rebranding: Regenerative agriculture, future‐pasts, and the naturalisation of livestock
Authors: Cusworth George , Lorimer Jamie , Brice Jeremy , Garnett Tara 
Published: June 2022

AbstractAnxieties around the relationship between livestock agriculture and the environmental crisis are driving sustained discussions about the place of beef and dairy farming in a sustainable food system. Proposed solutions range from ‘clean‐cow’ sustainable intensification to ‘no‐cow’, animal free futures, both of which encourage a disruptive break with past practice. This paper reviews the alternative proposition of regenerative agriculture that naturalises beef and dairy production by invoking the past to justify future, nature‐based solutions. Drawing on fieldwork in the UK, it first introduces two of the most prominent strands to this green rebranding of cattle: the naturalisation of ruminant methane emissions and the optimisation of soil carbon sequestration via the use of ruminant grazing animals. Subsequent thematic analysis outlines the three political strategies of post‐pastoral storytelling, political ecological baselining and a probiotic model of bovine biopolitics that perform this naturalisation. The conclusion assesses the potential and the risks of this approach to grounding the geographies and the temporalities of agricultural transition in the Anthropocene: an epoch in which time is out of joint and natures are multiple and non‐analogue, such that they provide slippery and contested grounds for political solutions.
Securing the pig farmgate? Biosecurity, affects and pathological atmospheres
Authors: Wang Chi‐Mao 
Published: June 2022

AbstractFaced with infectious disease threats, the global pork industry and the state have prioritised biosecurity in order to maintain porcine proliferation. Techniques such as good sanitation and surveillance are deemed necessary to ensure animal health. Rooted in germ theory, biosecurity regards disease as an incursion of pathogens from the outside. By drawing distinctions between healthy and diseased bodies, biosecurity regimes appear to represent an anthropocentric desire to control life through spatial enclosure. However, recent work on health geographies has revealed that health is a multifaceted configuration of changing relationships that often escape the purview of biosecurity. Critical studies have pointed out that the management of animal health relies less on any uniform understanding of disease and more on situated veterinary knowledge. This paper seeks to extend this body of work by emphasising inter‐species bodily encounters and earthly elements of the weather‐world. To elucidate this, I draw on recent research into atmosphere and affect, thereby developing the idea of pathological atmospheres. With reference to ethnographical work conducted in veterinary laboratories and commercial pig farms in Taiwan, I point out that a vet's situated expertise is conditioned by their ability to sense and respond to the atmospheric milieu in which they are immersed.
Effectiveness of social activity interventions for improving sleep among older people: a systematic review protocol
Authors: Naruse Takashi , Kynoch Kathryn , Sumikawa Yuka , Ramis Mary-Anne , Tuckett Anthony G. 
Published: June 2022

ABSTRACT

Objective:
The objective of this review is to evaluate the effectiveness of social activity interventions for improving sleep among older people.

Introduction:
Sleep is one of the most important functions for humans because it assists in maintaining health. Sleep disturbance is common in older people. Social activity has shown to be associated with better sleep in the older population; however, the effectiveness of these interventions is unclear.

Inclusion criteria:
This review will consider studies that include people aged 60 years or older. Any type of social activity intervention will be included. Outcomes will include both objective (eg, sleep time) and subjective sleep measures (eg, subjective sleep satisfaction). This review will consider both experimental and quasi-experimental study designs.

Methods:
MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, Cochrane Library, and Ichushi web will be searched for eligible studies. Sources of unpublished studies and gray literature to be searched include OpenGrey and ProQuest Dissertations and Theses. Studies published in any language will be considered. No date filter will be applied. Titles and abstracts will be screened by two independent reviewers who will then assess the full text of selected citations against the inclusion criteria. Eligible studies will be critically appraised by the reviewers using the JBI critical appraisal instruments. Where possible, studies will be pooled using meta-analysis. Where statistical pooling is not possible, the findings will be presented in narrative form. The degree of certainty of the evidence on sleep outcomes will be assessed using the GRADE approach.

Systematic review registration number:
PROSPEPO CRD42022315454
Experiences of health care professionals in intensive care when families participate in clinician handovers: a qualitative systematic review protocol
Authors: Wong Pauline , Gamble Andree , Jaspers Rose , Pope Nicole , Endacott Ruth 
Published: June 2022

ABSTRACT

Objective:
This review will evaluate the experiences of health care professionals in the intensive care unit when families participate in clinician handovers.

Introduction:
Families of patients admitted to the intensive care unit report stress and anxiety. Family participation in multidisciplinary rounds in the intensive care unit may improve patient and family outcomes. However, health care professionals have different attitudes toward family participation. Furthermore, there is limited understanding of the barriers, facilitators, and other outcomes of family participation in clinician handovers for the patient, family, and health care professionals.

Inclusion criteria:
The review will consider studies involving health care professionals (eg, nurses, physicians, allied health professionals) and any type of family participation, from bedside presence to participation in decision-making. Clinician handovers may be multidisciplinary ward rounds or nursing handovers. Settings may be the adult, pediatric, or neonatal intensive care unit in rural or metropolitan regions in any country. Studies in other clinical contexts will be excluded.

Methods:
Databases to be searched include CINAHL, MEDLINE, Scopus, PsycINFO, Embase, Emcare, Web of Science, and ProQuest Central. The search will be limited to articles written in English from 2000 to the present. Two independent reviewers will screen titles and abstracts, assess the full text of selected citations for inclusion, and assess methodological quality. A data extraction tool will be used, and findings will be assigned a level of credibility. Meta-aggregation will be used to synthesize findings. Disagreements between reviewers will be discussed to reach consensus; a third reviewer will be consulted if necessary.

Systematic review registration number:
PROSPERO CRD42020223011
Implementation of an Evidence-Based, Tai Ji Quan Fall Prevention Program in Rural West Virginia Churches: A RE-AIM Evaluation
Authors: Jones Dina L. , Selfe Terry Kit , Wen Sijin , Eicher Jennifer L. , Wilcox Sara , Mancinelli Corrie 
Published: June 2022

This study implemented a 16-week Tai Ji Quan: Moving for Better Balance® intervention for older adults in churches in hard-to-reach, medically underserved, rural communities, and evaluated the process using the RE-AIM Framework. Community-dwelling adults, aged 55 years, or older, were eligible. Data (N = 237) were collected at baseline, 16 weeks, and 32 weeks on falls efficacy, depression, physical/mental health-related quality of life, aerobic activity, gait speed, mobility, balance, and leg strength. Generalized/linear mixed models determined if outcomes improved. Eighteen churches sponsored 16 classes. Church adoption was 94%, instructor adoption was 86%, reach was 90%, and fidelity was good/fair. All outcomes improved except physical health-related quality of life and gait speed. Thirty-six percent of participants, 28% of churches, and 37% of instructors continued Tai Ji Quan: Moving for Better Balance at 32 weeks. Compared with two prior RE-AIM evaluations, adoption and reach rates, improvements in outcomes, and satisfaction were comparable; attendance, program completion, and continuation rates were lower.
ASA:

A

ccelerating

S

parse

A

ccumulation in Column-wise SpGEMM
Authors: Zhang Chao , Bremer Maximilian , Chan Cy , Shalf John , Guo Xiaochen 
Published: June 2022

Sparse linear algebra is an important kernel in many different applications. Among various sparse general matrix-matrix multiplication (SpGEMM) algorithms, Gustavson’s column-wise SpGEMM has good locality when reading input matrix and can be easily parallelized by distributing the computation of different columns of an output matrix to different processors. However, the sparse accumulation (SPA) step in column-wise SpGEMM, which merges partial sums from each of the multiplications by the row indices, is still a performance bottleneck. The state-of-the-art software implementation uses a hash table for partial sum search in the SPA, which makes SPA the largest contributor to the execution time of SpGEMM. There are three reasons that cause the SPA to become the bottleneck: (1) hash probing requires data-dependent branches that are difficult for a branch predictor to predict correctly; (2) the accumulation of partial sum is dependent on the results of the hash probing, which makes it difficult to hide the hash probing latency; and (3) hash collision requires time-consuming linear search and optimizations to reduce these collisions require an accurate estimation of the number of non-zeros in each column of the output matrix.
This work proposes ASA architecture to accelerate the SPA. ASA overcomes the challenges of SPA by (1) executing the partial sum search and accumulate with a single instruction through ISA extension to eliminate data-dependent branches in hash probing, (2) using a dedicated on-chip cache to perform the search and accumulation in a pipelined fashion, (3) relying on the parallel search capability of a set-associative cache to reduce search latency, and (4) delaying the merging of overflowed entries. As a result, ASA achieves an average of 2.25× and 5.05× speedup as compared to the state-of-the-art software implementation of a Markov clustering application and its SpGEMM kernel, respectively. As compared to a state-of-the-art hashing accelerator design, ASA achieves an average of 1.95× speedup in the SpGEMM kernel.
Expression of 11HOXGenes Is Deregulated in Esophageal Squamous Cell Carcinoma
Authors: Chen Ke-Neng , Gu Zhen-Dong , Ke Yang , Li Ji-You , Shi Xiao-Tian , Xu Guang-Wei 
Published: June 2022

AbstractPurpose: HOX genes are vital for all aspects of mammalian growth and differentiation, and recent data have shown that their deregulated expression is related to carcinogenesis. To date, there has been no systemic study on expression of HOX genes in esophageal carcinoma. We investigated the expression pattern of 39 known HOX genes in cancerous and noncancerous tissue from 36 patients with esophageal squamous cell carcinoma to determine whether their expression is altered in esophageal cancer.Experimental Design: Thirty-six patients with resectable esophageal squamous cell carcinoma (ESCC) were enrolled in this study. Specific primers were designed for each of 39 HOX genes, and reverse transcription-PCR was done in cancerous and noncancerous samples of these 36 patients. Furthermore, the expression of HOXA9 protein was subjected to Western blot analysis in all 36 paired tissue samples.Results: Eight of 39 HOX genes were expressed in cancerous but not in noncancerous tissue. Five of 39 HOX genes were expressed both in cancerous and noncancerous tissue. Of the latter, expression of HOXA7, HOXA9, and HOXC6 was significantly higher in cancerous tissue (P &lt; 0.05). The remaining 26 HOX genes were not detected in either types of tissue. HOXA9 protein was expressed in both kinds of tissue (cancer tissue versus noncancerous mucosa: 0.34 ± 0.32 versus 0.24 ± 0.27, P = 0.121).Conclusions: This is the first comprehensive survey of 39 HOX gene expression in ESCC and noncancerous mucosa. Five of the 39 HOX genes were expressed in both types of tissue indicating their possible role in maintaining normal structure and function of adult esophageal mucosa. Eleven of the 39 HOX genes were deregulated in cancer tissue. These genes possibly participate in the carcinogenesis of ESCC.
Coexpression of Erythropoietin and Erythropoietin Receptor in Von Hippel-Lindau Disease–Associated Renal Cysts and Renal Cell Carcinoma
Authors: Lee Youn-Soo , Vortmeyer Alexander O. , Lubensky Irina A. , Vogel Timothy W.A. , Ikejiri Barbara , Ferlicot Sophie , Benoît Gérard , Giraud Sophie , Oldfield Edward H. , Linehan W. Marston , Teh Bin T. , Richard Stéphane , Zhuang Zhengping 
Published: June 2022

Abstract
Von Hippel-Lindau (VHL) disease is characterized by multiple tumors in specific target organs. The tumors at different sites share distinct morphologic and genetic characteristics but their cell of origin is unknown. We show that VHL disease–associated renal clear cell carcinomas (RCC) consistently coexpress erythropoietin (Epo) and Epo receptor (EpoR). In addition, coexpression of Epo and EpoR is detected in many renal cysts, providing further evidence that renal cysts are potential precursors for RCC. In conjunction with VHL gene deficiency, coexpression of Epo and EpoR in renal cysts and tumors may reflect a developmental arrest in immature mesenchymal cells. Such arrest may lead to autocrine stimulation, cell proliferation, and renal tumor development, similar to tumorigenesis of VHL disease–associated hemangioblastomas.
Molecular Staging of Lymph Nodes from Patients with Esophageal Adenocarcinoma
Authors: Xi Liqiang , Luketich James D. , Raja Siva , Gooding William E. , Litle Virginia R. , Coello Michael C. , Finkelstein Sydney D. , Chestney Melissa L. , Landreneau Rodney J. , Hughes Steven J. , Godfrey Tony E. 
Published: June 2022

Abstract
Purpose: This study was designed to evaluate molecular markers for the detection of micrometastasis in esophageal adenocarcinoma, define algorithms to distinguish positive from benign lymph nodes and to validate these findings in an independent tissue set and in patients with pN0 esophageal adenocarcinoma.
Experimental Design: Potential markers were identified through literature and database searches. All markers were analyzed by quantitative reverse transcription (QRT)-PCR on a limited set of primary tumors and benign lymph nodes. Selected markers were further evaluated on a larger tissue set and classification algorithms were generated for individual markers and combinations. Algorithms were statistically validated internally as well as externally on an independent set of lymph nodes. Selected markers were then used to identify occult disease in lymph nodes from 34 patients with pN0 esophageal adenocarcinoma.
Results: Thirty-nine markers were evaluated, six underwent further analysis and five were analyzed in the external validation study. Two markers provided perfect classification in both the screening and validation sets, although parametric bootstrap analysis estimated 2% to 3% optimism in the observed classification accuracy. Several marker combinations also gave perfect classification in the observed data sets, and estimates of optimism were lower, implying more robust classification than with individual markers alone. Five of thirty-four patients with esophageal adenocarcinoma had positive nodes by multimarker QRT-PCR analysis and disease-free survival was significantly worse in these patients (P = 0.0023).
Conclusions: We have identified novel QRT-PCR markers for the detection of occult lymph node disease in patients with esophageal adenocarcinoma. The objective nature of QRT-PCR results, and the ability to detect occult metastases, make this an attractive alternative to routine pathology.