bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal and early-life environmental factors, family demographics and cortical brain anatomy in 5-year-olds: an MRI study from FinnBrain Birth Cohort
Authors: Silver Eero , Pulli Elmo P. , Kataja Eeva-Leena , Kumpulainen Venla , Copeland Anni , Saukko Ekaterina , Saunavaara Jani , Merisaari Harri , Lähdesmäki Tuire , Parkkola Riitta , Karlsson Linnea , Karlsson Hasse , Tuulari Jetro J. 
Published: July 2022

AbstractThe human brain develops dynamically during early childhood, when the child is sensitive to both genetic programming and extrinsic exposures. Recent studies have found links between prenatal and early life environmental factors, family demographics and the cortical brain morphology in newborns measured by surface area, volume and thickness. Here in this magnetic resonance imaging study, we evaluated whether a similar set of variables associates with cortical surface area and volumes measured in a sample of 170 healthy 5-year-olds from the FinnBrain Birth Cohort Study. We found that child sex, maternal pre-pregnancy body mass index, 5 min Apgar score, neonatal intensive care unit admission and maternal smoking during pregnancy associated with surface areas. Furthermore, child sex, maternal age and maternal level of education associated with brain volumes. Expectedly, many variables deemed important for neonatal brain anatomy (such as birth weight and gestational age at birth) in earlier studies did not associate with brain metrics in our study group of 5-year-olds, which implies that their effects on brain anatomy are age-specific. Future research may benefit from including pre- and perinatal covariates in the analyses when such data are available. Finally, we provide evidence for right lateralization for surface area and volumes, except for the temporal lobes which were left lateralized. These subtle differences between hemispheres are variable across individuals and may be interesting brain metrics in future studies.
Managing communities in decentralised social environments
Authors: Guidi Barbara , Michienzi Andrea , Ricci Laura 
Published: July 2022

AbstractMany decentralised systems can be represented as graphs, and the detection of their community structure can uncover important properties. Several community detection algorithms have been proposed, however, only a few solutions are suitable for detecting and managing communities in a distributed and highly dynamic environment. This lacking is mainly due to the difficulty of defining self-organising solutions in the presence of a high rate of dynamism. The main contribution of this paper is DISCO, a distributed protocol for community detection and management in a Peer-to-Peer dynamic environment. Our approach is mainly targeted to Decentralised Online Social Networks (DOSNs), but it can be applied in other distributed scenarios. In the context of DOSNs, DISCO allows to discover communities in the local social network of a user, named ego network, and to manage their evolution over time. DISCO is based on a Temporal Trade-off approach and exploits a set of super-peers for the management of the communities. The paper presents an extensive evaluation of the proposed approach based on a dataset gathered from Facebook and shows the ability of DISCO to orchestrate a set of nodes to detect and manage communities in a highly dynamic and decentralised environment. The paper also proposes a comparison with a state of the art approach, showing that it is capable of reducing the number of critical community lifecycle events by over 25%, and reducing the average loading factor by up to 50%.Graphical abstract
Solving the income-happiness paradox
Authors: Khalil Elias L. 
Published: July 2022

AbstractEasterlin notes a contradiction in the data. While the cross-sectional data set shows that happiness is a positive monotonic function of income, the time-series data set of high income countries demonstrates that happiness does not rise with the rise of income. To solve the paradox, this paper proposes that each data set reveals a different facet of happiness. The cross-sectional data set asks people how they assess their current well-being in general. This question prompts people to contrast their current well-being with a well-being in the distant past. This explains why happiness tracks income. In comparison, the time-series data ask people how they feel at the moment. This question prompts people to contrast their current well-being with an aspired goal in the future. Their response is a function of the gap that exists between their current well-being and the aspired one. The gap is usually steady for high income countries and, hence, happiness is likewise steady, i.e., insensitive to the rise of income. The proposed solution highlights the operation of contextual assessment: we have two facets of happiness following the two kinds of context in operation.
Slag characterization from the Roman vicus of Eisenberg (Germany)
Authors: Mittelstädt Katja , Himmelmann Ullrich , Berthold Christoph , Schwab Roland 
Published: July 2022

AbstractThe Roman vicus of Eisenberg in Rhineland-Palatinate (Germany) has always been considered to be an important Roman iron smelting centre due to numerous slag finds and relicts of furnaces. Most excavations that revealed iron working debris have been performed in the nineteenth or early twentieth century. Their results and interpretations have been considered to be doubtful, but more recent excavations have brought to light further relics of iron working processes, which have not, however, helped to clarify the situation. Therefore, slag and ore fragments from two locations of discovery were selected for investigation, because no systematic investigations have been carried out on slags or other relics of iron working so far, despite the enormous importance of such a place. The first results of this investigation clearly prove the smelting of iron in slag-tapping furnaces during Roman times due to the morphology of the slag, but they also show that the metallurgical debris is obviously not in situ and has been used as filling material. In addition, the high-grade haematite ores also found on the ground could serve as a source for smelting.
Post-COVID-19 condition is not only a question of persistent symptoms: structured screening including health-related quality of life reveals two separate clusters of post-COVID
Authors: Giszas Benjamin , Trommer Sabine , Schüßler Nane , Rodewald Andrea , Besteher Bianca , Bleidorn Jutta , Dickmann Petra , Finke Kathrin , Katzer Katrin , Lehmann-Pohl Katja , Lemhöfer Christina , Pletz Mathias W. , Puta Christian , Quickert Stefanie , Walter Martin , Stallmach Andreas , Reuken Philipp Alexander 
Published: July 2022

Abstract
Purpose
Some patients experience long-term sequelae after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, despite a present post-COVID condition, defined as “any symptom lasting longer than 12 weeks,” only a subset of patients search for medical help and therapy.

Method
We invited all adults with a positive real-time polymerase chain reaction (RT-PCR) for SARS-CoV-2 between March 2020 and September 2021 (n = 4091) in the city of Jena to answer a standardized questionnaire including demographic information, the course of the acute infection and current health status. K-means-clustering of quality of life (QoL) was used to explore post-COVID subgroups.

Results
A total of 909 participants at a median interval of 367 (IQR 291/403) days after acute infection were included in the analysis. Of those, 643 (70.7%) complained of having experienced persistent symptoms at the time of the survey. Cluster analysis based on QoL revealed two subgroups of people with persistent post-COVID symptoms. Whereas 189/643 participants (29.4%) showed markedly diminished QoL, normal QoL was detected in 454/643 individuals (70.6%).

Conclusion
Despite persistent symptoms being reported by nearly three quarters of participants, only one-third of these described a significant reduction in QoL (cluster 1), whereas the other two-thirds reported a near-normal QoL (cluster 2), thus indicating a differentiation between “post-COVID disease” and “post-COVID condition”. The prevalence of clinically relevant post-COVID disease was at least 20.7%. Health policies should focus on this subset.
Fabrication information modeling: interfacing building information modeling with digital fabrication
Authors: Slepicka Martin , Vilgertshofer Simon , Borrmann André 
Published: July 2022

AbstractDigital manufacturing methods have been successfully used in different industries for years and have since had a positive effect on the development of their productivity. These methods offer significantly greater design freedom and make it possible to develop shape-optimized and function-activated components. In the construction industry, however, these technologies are only being used reluctantly, even though additive methods could make resource-efficient construction possible. The possibly decisive disadvantage of these methods is that a significantly higher granularity of product and process information is required, thus significantly increasing the planning effort. A circumstance that the framework described in this study, fabrication information modeling (FIM), could significantly mitigate by linking digital fabrication and BIM-based digital building design via a digital chain. For this purpose, FIM provides a methodology with which the information of a digital building model can be detailed, component by component, in a fabrication-aware manner. Based on the open exchange data format IFC, the FIM framework integrates seamlessly into the BIM context and enables automated detailing of the design information.
Growth and design strategies of organic dendritic networks
Authors: Ciccone Giuseppe , Cucchi Matteo , Gao Yanfei , Kumar Ankush , Seifert Lennart Maximilian , Weissbach Anton , Tseng Hsin , Kleemann Hans , Alibart Fabien , Leo Karl 
Published: July 2022

AbstractA new paradigm of electronic devices with bio-inspired features is aiming to mimic the brain’s fundamental mechanisms to achieve recognition of very complex patterns and more efficient computational tasks. Networks of electropolymerized dendritic fibers are attracting much interest because of their ability to achieve advanced learning capabilities, form neural networks, and emulate synaptic and plastic processes typical of human neurons. Despite their potential for brain-inspired computation, the roles of the single parameters associated with the growth of the fiber are still unclear, and the intrinsic randomness governing the growth of the dendrites prevents the development of devices with stable and reproducible properties. In this manuscript, we provide a systematic study on the physical parameters influencing the growth, defining cause-effect relationships for direction, symmetry, thickness, and branching of the fibers. We build an electrochemical model of the phenomenon and we validate it in silico using Montecarlo simulations. This work shows the possibility of designing dendritic polymer fibers with controllable physical properties, providing a tool to engineer polymeric networks with desired neuromorphic features.
State Responsibility for International Bail Jumping
Authors: CURRIE ROBERT J. , MATHESON ELIZABETH 
Published: July 2022

AbstractOver the last decade, there has been a spate of incidents in Canada and the United States involving Saudi Arabian nationals who, while out on bail for predominantly sexual crimes, were able to abscond from the countries despite having surrendered their passports. Investigation has revealed evidence supporting a reasonable inference that the government of Saudi Arabia has, in fact, assisted its nationals to escape on these occasions. This article makes the case that this kind of conduct amounts not just to unfriendly acts but also to infringements upon the territorial sovereignty of both states and serious breaches of the international law of jurisdiction. It surveys the possible remedies available to both injured states and, in light of the fact that neither state has sought any such remedy, examines possible remedial routes for the victims of the Saudi nationals’ crimes. It remarks upon the utter failure of either Canada or the United States to address these acts, concluding that such wilful neglect both corrodes sovereignty and undermines the will to address sexual crimes.
Climate Change and International Legal Personality: “Climate Deterritorialized Nations” as Emerging Subjects of International Law?
Authors: LAPAŠ DAVORIN 
Published: July 2022

AbstractThis article deals with the sea level rise phenomenon caused by the climate change process and its impact on the statehood of so-called disappearing island states as well as on the consequent factual and legal status of their populations. In classical international law doctrine, the loss of a state’s territory will lead to the extinction of statehood and, consequently, the loss of that state’s international legal personality, and possibly also to the statelessness of its nationals. This article proposes an alternative solution based on the transformation of disappearing island states into new non-territorial subjects of international law — “climate deterritorialized nations” — as successors to disappeared inundated states.
The Failure of “Yugoslavia’s Last Chance”: Ante Marković and his Reformists in the 1990 Elections
Authors: Glaurdić Josip , Filipović Vladimir , Lesschaeve Christophe 
Published: July 2022

AbstractThe last Prime Minister of Yugoslavia Ante Marković was considered by many within the country and in the international community to be Yugoslavia’s last chance for a peaceful transition toward democracy and capitalism. In spite of his popularity, the Reformist party he created failed decisively in the first democratic elections of 1990. We expose the reasons for this failure by analyzing electoral, economic, and sociodemographic data on the level of more than two hundred Yugoslav municipalities where the Reformists put forward their candidates. Our analysis shows that the party’s failure had little to do with the voters’ exposure to the effects of the free market reforms undertaken by Marković’s federal government during this period. Instead, the Reformists’ results were largely determined by the communities’ ethnic makeup and interethnic balance. The Reformists suffered at the hands of a strong negative campaign by the Serbian regime of Slobodan Milošević, and they were squeezed out by the ethnically based parties that benefited from voters behaving strategically in the electoral marketplace dominated by questions of nationalism. The analysis presented here offers important lessons for our understanding of Yugoslavia’s breakup, post-communist transitions in general, and electoral politics in societies on the verge of ethnic conflict.
Integrating morphological and contextual cues in lexical inferencing of Chinese fourth graders
Authors: Zhang Huan , Zhang Jie , Han Chunxiang , Zhou Xuelian , Su Yongqiang , Li Hong 
Published: July 2022

AbstractThe study investigated the strategies used by Chinese students in inferring meanings of unfamiliar words and the influential factors of successful use of different lexical inferencing strategies. A total of 104 fourth graders inferred 36 unfamiliar semitransparent compound words in three conditions: word in isolation, contextual information only, and both word and context. Results revealed that students were more likely to obtain the correct meaning of words when both morphological information and contextual information were available. The likelihood of using a morpheme-based or context-based lexical inferencing strategy was strongly influenced by the presentation condition of target words and precursors. Students with higher vocabulary knowledge and reading comprehension ability were more sensitive to morphological and contextual information and were able to synthesize multiple sources of information, whereas children with lower vocabulary knowledge and reading comprehension ability showed difficulties in integration and tended to overly rely on morphological information. The findings reveal the interactions between available source information and individual differences in vocabulary knowledge and reading comprehension in predicting lexical inferencing and have implications for vocabulary and reading instruction.
Gina Oselio and Opera inFin-de-SiècleNorway
Authors: Sasser Patricia Puckett 
Published: July 2022

AbstractIn 1888, Norwegian newspapers eagerly announced the arrival of ‘Miss Gina Oselio’, who was returning to Norway ‘after seven years of staying abroad’. Oselio (Ingeborg Aas (1858–1937)) had achieved tremendous success as an opera singer in Europe and her performance on the Norwegian concert stage did not disappoint. Her new popularity positioned the singer as a member of the country's cultural elite and introduced a new complexity to her operatic identity. Unlike other Norwegian musicians who were treated primarily in terms of their nationality, her ‘Norwegianness’ had been largely incidental during her career. Oselio's private papers, however, offer new insights into the complex relationship between the singer and the nation. Together with her reception history, these materials invite a fresh examination of Oselio's position infin-de-siècleNorwegian musical life. They show how she cultivated her career and her identity outside Norway, as well as her deliberate decision to assert her ‘Norwegianness’. They demonstrate the roles that Oselio wished to occupy on the country's stages and how other Norwegians responded to these roles. Ultimately, they document a period of transition, as artists, critics and audiences sought to determine the place that opera would occupy within the nation.
Turning a Silk Purse into a Sow's Ear: A Speculative Note on Humay and Humayun in Philadelphia
Authors: SIMPSON MARIANNA SHREVE 
Published: July 2022

AbstractThe Rare Books department at the Free Library of Philadelphia owns a deluxe manuscript of Sa'di's Kulliyat, originally produced in mid-sixteenth century Shiraz and substantially modified in more modern times. Among the alterations was the insertion of a copy of the famous Timurid painting “Humay and Humayun in a garden”, belonging to the Musée des Arts Décoratifs, Paris. The Philadelphia version of the Paris painting was likely based on either a published reproduction or a photograph taken of the original composition when it was on view at the ground-breaking 1910 exhibition “Meisterwerke muhammedanischer Kunst” in Munich. That photographic reproductions could result in pictorial replicas reveals once again the market forces behind the great interest in, demand for, and production of classical Persian painting during the early twentieth century.
Altered neural flexibility in children with attention-deficit/hyperactivity disorder
Authors: Yin Weiyan , Li Tengfei , Mucha Peter J. , Cohen Jessica R. , Zhu Hongtu , Zhu Ziliang , Lin Weili 
Published: July 2022

AbstractAttention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood, and is often characterized by altered executive functioning. Executive function has been found to be supported by flexibility in dynamic brain reconfiguration. Thus, we applied multilayer community detection to resting-state fMRI data in 180 children with ADHD and 180 typically developing children (TDC) to identify alterations in dynamic brain reconfiguration in children with ADHD. We specifically evaluated MR derived neural flexibility, which is thought to underlie cognitive flexibility, or the ability to selectively switch between mental processes. Significantly decreased neural flexibility was observed in the ADHD group at both the whole brain (raw p = 0.0005) and sub-network levels (p < 0.05, FDR corrected), particularly for the default mode network, attention-related networks, executive function-related networks, and primary networks. Furthermore, the subjects with ADHD who received medication exhibited significantly increased neural flexibility (p = 0.025, FDR corrected) when compared to subjects with ADHD who were medication naïve, and their neural flexibility was not statistically different from the TDC group (p = 0.74, FDR corrected). Finally, regional neural flexibility was capable of differentiating ADHD from TDC (Accuracy: 77% for tenfold cross-validation, 74.46% for independent test) and of predicting ADHD severity using clinical measures of symptom severity (R2: 0.2794 for tenfold cross-validation, 0.156 for independent test). In conclusion, the present study found that neural flexibility is altered in children with ADHD and demonstrated the potential clinical utility of neural flexibility to identify children with ADHD, as well as to monitor treatment responses and disease severity.
PLAA suppresses ovarian cancer metastasis via METTL3-mediated m6A modification of TRPC3 mRNA
Authors: Shen Zhangjin , Gu Lingkai , Liu Yuwan , Wang Lingfang , Zhu Jiawei , Tang Sangsang , Wei Xinyi , Wang Jiaying , Zhang Songfa , Wang Xinyu , Cheng Xiaodong , Xie Xing , Lu Weiguo 
Published: July 2022

AbstractWide metastasis contributes to a high death rate in ovarian cancer, and understanding of the molecular mechanism helps to find effective targets for metastatic ovarian cancer therapy. It has been found that phospholipase A2-activating protein (PLAA) is inactivated in some cancers, but its role in cancer metastasis remains unknown. Here, we found that PLAA was significantly downregulated in ovarian cancer highly metastatic cell lines and patients, and the low expression of PLAA was associated with poorer prognosis and high-risk clinicopathological features of patients. PLAA inhibited the migration and invasion of ovarian cancer cells and metastasis of transplanted tumor in the orthotopic xenograft mouse model. Meanwhile, PLAA inhibited metastasis of ovarian cancer by inhibiting transient receptor potential channel canonical 3 (TRPC3)-mediated the intracellular Ca2+ level. Mechanistically, PLAA inhibited methyltransferase-like 3 (METTL3) expression through the ubiquitin-mediated degradation, and METTL3 stabilized TRPC3 mRNA expression via N6-methyladenosine (m6A) modification. Our study verified the function and mechanism of the PLAA-METTL3-TRPC3 axis involved in ovarian cancer metastasis, with a view to providing a potential therapeutic approach for ovarian cancer.
Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage
Authors: Wu Xiaobing , Guo Maoni , Cui Jian , Cai Haoyang , Wang San Ming 
Published: July 2022

AbstractBRCA1 mutation is the genetic predisposition in causing genome instability towards cancer. BRCA1 mutation is predominantly germline inherited at the fertilization. However, when the inherited mutation initiates genome instability in the mutation carriers remains largely elusive. We used a heterozygotic Brca1-knockout mouse as a model to investigate the issue. Through whole-genome sequencing and bioinformatics analysis, we monitored genome status across the developmental stages from embryo to adulthood in the mouse model. We observed that genome instability as reflected by structural variation, indel and copy number variation already appeared at 10.5-day embryo and progressively towards adulthood. We also observed that the genome instability was not linearly accumulated but dynamically changed along the developmental process, affecting many oncogenic genes and pathways including DNA damage repair, estrogen signaling, and oncogenesis. We further observed that many genome abnormalities in the cancer caused by Brca1 mutation were originated at embryonic stage, and Trp53 (TP53) mutation was not essential for the Brca1 mutation-caused genome instability in the non-cancer cells. Our study revealed that heterozygotic Brca1 mutation alone can cause genome instability at embryonic stage, highlighting that prevention of BRCA1 mutation-related cancer in humans may need to start earlier than currently considered.