bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bedside temporary transvenous cardiac pacing lead placement in patients with tricuspid valve surgery without guidance of X‐ray: A single‐center experience
Authors: Chen Mingxian , Wang Zhuo , Wang Songyun , Zhu Tongjian , Liu Zhenjiang , Li Xuping , Wu Zhihong , Liu Qiming , Zhou Shenghua 
Published: September 2022

AbstractBackgroundIt is difficult to insert cardiac pacing leads in patient with tricuspid valve surgery (TVS). The aim of this study was to evaluate safety and effectiveness of a novel technique applied for bedside temporary pacemaker placement (TPP) in patients with TVS.MethodsWe investigated patients with TVS who required bedside TPP without X‐ray guidance in cardiac intensive care unit between January 2019 and March 2022. They were divided into Novel pre‐shaped group (N = 21) and Control group (routine pre‐shaped group, N = 26). The ordinary bipolar electrodes were applied in both groups. In Novel pre‐shaped group, electrodes were reshaped by a novel technique with three‐curve with anterior tip method, while electrodes were shaped by traditional strategy in Control group. We evaluated the operation duration, first‐attempt success rate of the lead placement, pacing threshold, success rate of lead placement, the rate of leads displacement, and complications.ResultsCompared with that in Control group, the procedure time was significantly shortened and the first‐attempt success rate of lead placement was obviously increased in Novel pre‐shaped group (both p < 0.05). Although there was a slight reduction in complications in Novel pre‐shaped group when compared with that in Control group. However, there were no statistical significance in pacing threshold, the success rate of lead placement, the rate of leads displacement, and complications when compared between two groups.ConclusionsWe propose a novel technique, three‐curve with anterior tip method, is a feasible and effective bedside method to insert emergency temporary pacing leads in patients with TVS.
Definitive antibiotic treatment with a third‐generation cephalosporin and with piperacillin‐tazobactam worked well for some children with Serratia bacteraemia
Authors: Fanous Eliana , Schiller Ofer , Kaplan Eytan , Vardi Yoav , Herscovici Tina , Ben‐Zvi Haim , Mor Meirav , Livni Gilat 
Published: September 2022

AbstractAimThis study aimed to describe epidemiological and clinical characteristics of Serratia bacteraemia and to identify factors associated with mortality.MethodsThe microbiology database of Schneider Children's Medical Centre of Israel was examined for Serratia marcescens positive blood cultures, between January 2007 and May 2020. Demographic, clinical and microbial characteristics were analysed.ResultsOf the 81 patients files that met the inclusion criteria, 64 (80%) were of patients hospitalised in paediatric intensive care units. The median age was 78 days and 54% were male. In‐hospitalisation mortality was 26%, 62% died under 90 days old. Underlying conditions including prematurity, congenital cardiac defects and malignancies were noted in 95% of patients. Prior to the bloodstream infections, 62% of patients underwent procedures, 64% were on ventilatory support and 77% had central lines. Thrombocytopenia and elevated C‐reactive protein levels were found in 60% of the children. Twenty‐eight children received definitive monotherapy as either piperacillin‐tazobactam or a third‐generation cephalosporin; survival rates were similar between the two antibiotic treatment groups.ConclusionIn our cohort, 26% died. Death was more common in young infants. Mortality was associated with hospitalisation in intensive care units and thrombocytopenia. Survival rates following definitive monotherapy were similar for patients treated with piperacillin‐tazobactam and those treated with third‐generation cephalosporin.
Peptide epitopes as biomarkers of soya sensitization in rBet v 1 immunotherapy of birch‐related soya allergy
Authors: Caballero Lisbeth Ramírez , Treudler Regina , Delaroque Nicolas , Simon Jan C. , Kern Karolin , Szardenings Michael 
Published: September 2022

AbstractBackgroundThere are no diagnostic and/or prognostic markers of the treatment outcome in patients receiving allergen immunotherapy (AIT). Although numerous allergen epitopes are known, their value in this context has not been investigated. This paper deals with re‐evaluation of sera from patients who underwent AIT against rBet v 1 for treatment of their soya allergy (BASALIT trial).ObjectiveTo evaluate the diagnostic and/or prognostic potential of allergen epitopes recognition by antibodies from patients with birch‐related soya allergy before and after rBet v 1‐immunotherapy.MethodsPR‐10 epitope‐binding profiles from 34 patients were identified in silico using a statistical peptide phage display at start and at end of AIT. IgE‐ and IgG‐binding to these peptide epitopes was measured in peptide microarrays. Clinical relevance of epitopes was evaluated by comparing these measurements to a number of treatment outcome measures recorded during double‐blind placebo‐controlled food challenge at start and end of AIT.ResultsWe showed that IgG‐ and IgE‐recognition of peptide epitopes after AIT were surrogate markers of 5 out of 12 analysed treatment outcome measures using this patient cohort. Seven epitopes were identified from multiple PR‐10 allergen sequences. Twenty‐six peptide epitopes were used for IgG and IgE measurements. IgE‐binding to one of the epitopes was associated with stronger intensity of oral tingling/itching after ingesting soya at start of AIT. IgG recognizing two other epitopes at start of AIT could predict decreased Cor a 1‐specific IgE concentration (p = .043) and decreased lip swelling intensity (p = .016) after AIT. Tolerance to increasing amounts of soy at food challenge correlated with IgG‐binding to another epitope at start of AIT (p = .046).ConclusionIgG‐ and IgE‐binding to peptide epitopes in PR‐10 is a potential indicator of the outcome and clinical course of AIT of soya‐sensitized patients with rBet v 1.
Geographic hot spots of kidney transplant candidates wait‐listed post‐dialysis
Authors: Buchalter R. Blake , Huml Anne M. , Poggio Emilio D. , Schold Jesse D. 
Published: September 2022

AbstractIntroductionPreemptive wait‐listing of deceased donor kidney transplant (DDKT) candidates before maintenance dialysis increases the likelihood of transplantation and improves outcomes among transplant patients. Previous studies have identified substantial disparities in rates of preemptive listing, but a gap exists in examining geographic sources of disparities, particularly for sub‐regional units. Identifying small area hot spots where delayed listing is particularly prevalent may more effectively inform both health policy and regionally appropriate interventions.MethodsWe conducted a retrospective cohort study utilizing 2010–2020 Scientific Registry of Transplant Recipients (SRTR) data for all DDKT candidates to examine overall and race‐stratified geospatial hot spots of post‐dialysis wait‐listing in U.S. zip code tabulation areas (ZCTA). Three geographic clustering methods were utilized to identify robust statistically significant hot spots of post‐dialysis wait‐listing.ResultsNovel sub‐regional hot spots were identified in the southeast, southwest, Appalachia, and California, with a majority existing in the southeast. Race‐stratified results were more nuanced, but broadly reflected similar patterns. Comparing transplant candidates in hot spots to candidates in non‐clusters indicated a strong association between residence in hot spots and high area deprivation (OR: 6.76, 95%CI: 6.52‐7.02), indicating that improving access healthcare in these areas may be particularly beneficial.ConclusionOur study identified overall and race‐stratified hot spots with low rates of preemptive wait list placement in the U.S., which may be useful for prospective healthcare policy and interventions via targeting of these narrowly defined geographical areas.
Utility of the tricuspid annular tissue doppler systolic velocity and pulmonary artery systolic pressure relationship in right ventricular systolic function assessment: A pilot study
Authors: López‐Candales Angel , Vallurupalli Srikanth 
Published: September 2022

AbstractBackgroundTricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP) ratio has been validated as a valuable noninvasive measure of right ventricular (RV) elastance and systolic function. However, the more reliable TA systolic (s’) velocity measure of RV systolic function compared to TAPSE has not been previously studied.MethodsWe conducted a pilot study using several variables of RV function in 50 patients with the main aim to determine which numerical expression between TA TDI s’/PASP and TAPSE/PASP ratio was most useful.ResultsIn a stepwise multiple regression analysis, TA TDI s’/PASP ratio (p < .0002); LVOT VTI/RVOT VTI ratio (p < .0002); RVOT VTI (p < .0047); TAPSE/PASP ratio (p < .0259) and TA TDI e’ (p < .0292) were best in discriminating normal versus abnormal RV systolic function. Using receiver operator curve analysis, cut‐off values for both TA TDI s’/PASP (>3.9 mm/c/mmHg) had 82.1% sensitivity and 77.3% specificity while the TAPSE/PASP (>.61 mm/mmHg) had 89.3% sensitivity and 68.2% specificity in identifying normal RV function in our studied population.ConclusionOur results indicate that TA TDI s’/PASP is a better mathematical expression when examining the relationship between RV contractility and RV resistance relationship. Furthermore, we also found that inclusion of RVOT VTI, RV diastolic properties, and left ventricular systolic function are important determinants of RV systolic function assessments and should be routinely included. Additional prospective studies are now needed to confirm these results using hemodynamic data.
An isolated congenital absence of right pulmonary artery associated with pulmonary hypertension with coronary collaterals: A case report
Authors: Demir Muhammed , Akdağ Serkan , Deniz Muhammed Akif , Şimşek Hakkı 
Published: September 2022

AbstractUnilateral absence of pulmonary artery (UAPA) resulting from a defect in the aortic arch's embryogenesis. Patients who survive into adulthood is rare. Herein, we presented a case of UAPA with pulmonary hypertension in a 49‐year old female.
Acceleration of vegetation phenological changes
Authors: Chen Min 
Published: September 2022

AbstractPiao et al. (2022) presents an interesting study on vegetation phenology from a novel angle. The study examined the speed of canopy development and senescence, or the “acceleration of vegetation phenological changes”, and investigated its relationship with the trend of vegetation greening/browning and the underlying climate driving factors. It is an important contribution to the understanding of vegetation response to climate change, and may inspire new directions of vegetation phenology research.
Serum globulin levels are associated with HIV reservoir size and immune restoration during long‐term ART
Authors: Zhang Qing , Jiao Yan‐Mei , Li Guang , Zhang Lu‐Xue , Gao Lin , Guo Xiao‐Yan , Mijiti Zilaiguli , Guo Yun‐Tian , Xu Wen , Huang Hui‐Huang , Wang Fu‐Sheng 
Published: September 2022

AbstractObjectivesThe objectives of this study were to analyze the relationship between serum globulin levels and immune restoration and HIV reservoir size during long‐term antiretroviral therapy (ART).MethodsWe enrolled 13 patients living with HIV who had been receiving ART for 5 years. We measured levels of serum globulin, cell‐associated (CA) HIV DNA and RNA, and p24 antibody at 0, 1, 3, and 5 years of ART. CD38 and human leukocyte antigen – DR isotype (HLA‐DR) were used as activation markers for T‐cell activation. Serum concentrations of the inflammatory cytokines interferon gamma‐inducible protein (IP)‐10 and soluble CD163 (sCD163) were detected by enzyme‐linked immunosorbent assay. We analyzed the relationship between serum globulin levels, HIV reservoir size, immune restoration, T‐cell immune activation, and inflammatory levels during long‐term ART.ResultsOur data showed that serum globulin levels in people living with HIV were higher than in healthy controls and significantly decreased during the first year of ART. Serum globulin levels during long‐term ART were positively correlated with CA HIV DNA, CA HIV RNA, p24 antibody levels, and CD8+ T‐cell counts and negatively correlated with CD4+ T‐cell counts and CD4/CD8 ratios. Moreover, serum globulin levels were positively correlated with CD4+ and CD8+ T‐cell activation and the concentrations of inflammatory biomarkers IP‐10 and sCD163 during long‐term ART.ConclusionsOur findings suggest that serum globulin levels may be associated with HIV reservoir size and immune restoration during long‐term ART.
Association between gestational weight gain and risk of overweight at 3 years old: The Japan Environment and Children's Study
Authors: Tanigawa Kanami , Kawanishi Yoko , Ikehara Satoyo , Kimura Takashi , Ueda Kimiko , Kimura Tadashi , Ozono Keiichi , Iso Hiroyasu ,   the Japan Environment and Children's Study Group
Published: September 2022

SummaryBackgroundIt is unclear if gestational weight gain (GWG) increases the risk of children with overweight.ObjectivesWe examined the association between GWG and the risk of overweight in 3‐year‐old children in the Japanese nationwide birth cohort study.MethodsAmong 64 336 singleton births, we calculated the risk ratios (RRs) and 95% confidence intervals (95% CIs) of the association between GWG categories and children with overweight, following an adjustment of the confounding variables.ResultsGWG was positively associated with the risk of overweight among 3‐year‐old children. The multivariable RR (95% CI) was 1.21 (1.17–1.25) per 5 kg increase of the GWG. The multivariable RR (95% CI) for excessive GWG was 1.20 (1.12–1.28) and 1.27 (1.16–1.39) based on the modified Japanese and IOM criteria, respectively, compared to adequate GWG. The multivariable RR (95% CI) of overweight with children for inadequate versus adequate GWG was 0.83 (0.78–0.88) and 0.84 (0.79–0.89) based on the modified Japanese and IOM criteria, respectively.ConclusionsGWG was positively associated with a high risk of overweight at 3 years of age. The risk of offspring overweight was 20%–27% higher and 16%–17% lower with excessive GWG and inadequate GWG, respectively, compared to adequate GWG, based on the aforementioned criteria.
Significant inverse association of testosterone level with penile deformity severity in Japanese males with Peyronie's disease
Authors: Mitsui Yozo , Yamabe Fumito , Hori Shunsuke , Uetani Masato , Aoki Hiroshi , Sakurabayashi Kei , Okawa Mizuho , Kobayashi Hideyuki , Nakajima Koichi , Nagao Koichi 
Published: September 2022

AbstractObjectivesWe evaluated the relationship between penile curvature and testosterone in Peyronie's disease patients treated in Japan.MethodsData were obtained from 109 patients with Peyronie's disease treated with surgery at our hospital between April 2004 and December 2019. Penile deformity assessment was based on findings of a rigid erection induced by intracavernosal injection. Low total testosterone level was defined as <300 ng/dl. Patients were divided into two groups according to curvature severity (I, <60°; II ≥60°), then clinical factors including total testosterone were compared. Uni‐ and multivariate logistic regression analyses were performed to identify factors predicting severe penile deformity (≥60°).ResultsFor all patients, mean total testosterone was 469 ng/dl and median curvature was 50°, with a significant inverse correlation found between curvature and testosterone level (p < 0.0001). Group I and II patients numbered 55 and 54, respectively. Mean total testosterone for Group II was 397 ng/dl, significantly lower than Group I (539 ng/dl). Median curvature in 15 patients with a low testosterone level was 80°, significantly higher than those with a normal testosterone range (50°). Univariable and multivariable logistic regression analysis indicated total testosterone, follicle stimulating hormone, and C‐reactive protein as significant factors correlated with severe penile deformity, among which total testosterone was most relevant.ConclusionThe present findings confirmed that penile deformity severity is correlated with testosterone level in Japanese males with Peyronie's disease.
Overview of recent advancements in asthma management
Authors: Witt Ashleigh , Douglass Jo A. , Harun Nur‐Shirin 
Published: September 2022

AbstractAsthma is a common but complex heterogenous inflammatory airway disorder. Despite significant developments in our understanding of the pathophysiology and treatment of asthma, it remains a major cause of mortality and morbidity. Optimal management involves addressing modifiable risk factors, titration of inhaled pharmacotherapy in a stepwise approach and, in severe disease, consideration of biologic agents. Appreciation of the clinical characteristics of asthma and recognition of the immune pathways involved has allowed the development of phenotypic and endotypic subtypes of asthma to be better defined. This has revolutionised asthma management, allowing risk stratification of patients, targeted use of biologic agents to modify cytokine responses that drive asthma and improved patient outcomes. Patient education and engagement are critical to the management of this disease in an era of personalised medicine and a rapidly changing global environment.
Intracellular complement: Evidence, definitions, controversies, and solutions
Authors: King Ben C. , Blom Anna M. 
Published: September 2022

SummaryThe term “intracellular complement” has been introduced recently as an umbrella term to distinguish functions of complement proteins that take place intracellularly, rather than in the extracellular environment. However, this rather undefined term leaves some confusion as to the classification of what intracellular complement really is, and as to which intracellular compartment(s) it should refer to. In this review, we will describe the evidence for both canonical and non‐canonical functions of intracellular complement proteins, as well as the current controversies and unanswered questions as to the nature of the intracellular complement. We also suggest new terms to facilitate the accurate description and discussion of specific forms of intracellular complement and call for future experiments that will be required to provide more definitive evidence and a better understanding of the mechanisms of intracellular complement activity.
Fabrication of submicron Li‐rich Li2(Ti,Zr)O3 solid solution ceramics with sluggish grain growth rate
Authors: Guo Hao , Shi Yanli , Lu Zhonghua , Wang Gaoyuan , Deng Mao , Wang Haomin , Qi Jianqi , Lu Tiecheng 
Published: September 2022

AbstractDoping and forming solid solution is an effective approach to tailor densification and grain growth. In this study, submicron Li2(Ti,Zr)O3 solid solution ceramics was successfully fabricated by a modified solid‐state route for the first time. The use of appropriate starting powders can greatly reduce the synthesis temperature, and the preparation of Li2(Ti,Zr)O3 with submicron grain size is possible. The substitution of Ti by Zr will inhibit the phase transition from cubic to monoclinic structure, as well as the grain growth and pore removal. By doping 10‐at.% Zr, the grain size was significantly decreased from several μm to 400 nm at 900°C, which contributes to a high conductivity eight times that of pure Li2TiO3. Moreover, after being heated at 900°C for 10 days, the grain size of Li2(Ti,Zr)O3 only increases to 5 μm; however, the grains of Li2TiO3 grows up to 16 μm with abnormal grain growth. The compositions of Li2(Ti,Zr)O3 are high uniform with no element segregation, indicating the sluggish grain growth rate is caused by the slow diffusion of Zr rather than segregation‐induced solute drag. By adding excess Li and two‐step sintering, the Li‐rich Li2(Ti,Zr)O3 ceramic pebbles with high crush load of 50–60 N and small grain size of 300–500 nm were successfully fabricated. This work demonstrates a simple method for the synthesis of Li2(Ti,Zr)O3, which makes this material more widely accessible for exploration and also help accelerate its engineering application to be an advanced solid breeder.
Phylogenomics and evolutionary diversification of the subfamily Polygonoideae
Authors: Zhang Lu‐Shui , Chen Chun‐Lin , Mao Xing‐Xing , Liu Jian‐Quan 
Published: September 2022

AbstractMany species of the subfamily Polygonoideae are economically important. However, phylogenetic relationships and taxonomic treatments of these species remain disputed. In this study, we used highly orthologous nuclear genes and plastome sequence variation extracted from transcriptomes from 98 species of 26 genera of Polygonaceae mainly from the subfamily Polygonoideae to construct a robust phylogeny. We discerned six successively diverged and well‐defined clades and both nuclear and plastome phylogenies are highly consistent with each other in this subfamily. Phylogenetic relationships between all clades and subclades were well resolved within Polygonoideae. Our analyses revealed that the shrub tribe Atraphaxideae and the herbal genera Polygonum, Persicaria, and Fallopia are polyphyletic. The sampled species of Polygonoideae started to diversify around the Cretaceous/Tertiary boundary (70 Ma) when the global climate exhibited large oscillations. Further origins of more herbal and woody species were found to have clearly increased during later climatic oscillations. We found that woody habits, especially shrubs, originated multiple times from ancestral herbs in this subfamily. Local dry climates may have favored such habit shifts from ancestral herbs. Our results deepen our understanding of evolutionary diversification of Polygonoideae.