bluuebunny/crossref_metadata_2025_split huggingface dataset:
Itinéraire méthodologique d’un sociologue qui avait étudié les mathématiques
Authors: Grossetti Michel 
Published: February 2025

Résumé Dans ce texte, je reviens sur mon parcours de chercheur, abordé sous l’angle des méthodes que j’ai utilisées, dont certaines ont été développées avec divers collègues sur la base de techniques existantes. Formé au départ en mathématiques appliquées, j’ai évidemment utilisé les outils de l’analyse statistiques de données, mais je me suis aussi beaucoup intéressé aux entretiens et à l’histoire orale, qui forment la base de la méthode des narrations quantifiées.
Injectable ADM temperature-sensitive hydrogel loaded with bFGF in diabetic rat wound healing study
Authors: Chen Haojiao , Sun Jianping , Liu Wenyang 
Published: February 2025

Background: Diabetic wound is one of the most common diabetic chronic complications. Effective treatments of diabetic wound remain limited. Here, we explored the effects of basic fibroblast growth factor (bFGF)-acellular dermal matrix (ADM) hydrogel on the diabetic wound. Methods: The bFGF-ADM hydrogel was manufactured by mixing 180 µL ADM hydrogel and 20 µL bFGF aqueous solution (10 mg/mL). The morphology of ADM hydrogel and bFGF-ADM hydrogel was observed under scanning electron microscope. The release property of bFGF-ADM hydrogel was determined by ELISA. CCK-8 assay was utilized to estimate the cell viability of mouse skin fibroblasts. The diabetes mellitus (DM) model was established in rats. The four wounds on the back of each DM rat were treated with the ADM hydrogel, bFGF-ADM hydrogel, bFGF aqueous solution and no solution (control), respectively. The wound healing rate of each rat was estimated. The traumatized skin tissue of each rat was observed by H&E staining and Sirius red staining. Results: The bFGF-ADM hydrogel displayed an interconnected pore structure and bFGF was gradually released from the bFGF-ADM hydrogel over time. The bFGF-ADM hydrogel could enhance the cell viability of skin fibroblasts and promote the wound healing rate, the re-epithelialization of wound and increase the collagen fiber content of dermis. And the bFGF-ADM hydrogel exhibited better therapeutic effects of diabetic wound than either bFGF or ADM alone. Conclusions: Our study revealed that the bFGF-ADM hydrogel could promote diabetic wound healing.
Dance-specific Aerobic Fitness Test (DAFT) Heart Rate Variables are not Associated with Lower-Extremity Injuries in Contemporary Dance Students
Authors: Tiemens Annemiek , Plaatsman Larissa A. , van Rijn Rogier M. , Koes Bart W. , Stubbe Janine H. 
Published: February 2025

Introduction: The purpose of the study was to examine if dance-specific aerobic fitness test (DAFT) heart rate variables were associated to lower-extremity injuries in contemporary dance students. Methods: A total of 235 first-year contemporary dance students (18.6 ± 1.2 years) were prospectively followed over the first 4 months of their academic year. Peak heart rate (HRpeak) in the final stage of the DAFT and heart rate recovery (HRR) 1 minute after DAFT completion were measured. Lower-extremity injuries were registered using a self-reported monthly questionnaire including the Oslo Sports Trauma Research Centre Questionnaire on Health Problems (OSTRC-H). Three injury definitions were used (all-complaint injury, substantial injury, and time-loss injury). Associations between DAFT HRpeak, HRR and lower-extremity injury prevalence and severity were examined with regression analyses. Results: Lower-extremity injury prevalence was 36.2% (n = 85), 13.6% (n = 32), and 22.6% (n = 53) for all-complaint, substantial and time-loss injuries, respectively. There were no significant associations between HRpeak or HRR and injury prevalence using either of the 3 injury definitions. There were no significant associations between DAFT HRpeak or HRR and injury severity (days off due to injury or OSTRC-H severity score). Multivariate analyses showed significant associations between age and substantial injuries (OR 1.807; 95% CI 1.242-2.630; P < .01) and between age and time-loss injuries (OR 1.441; 95% CI 1.074-1.933; P < .05). Conclusion: Aerobic fitness measured with the DAFT was not associated with lower-extremity injury risk or injury severity. Higher age was associated with substantial and time-loss lower-extremity injuries.
Radiation-associated angiosarcoma of the breast: radical resection technique of the entire radiation field
Authors: Thiel Johannes Tobias , Bauer Michael , Daigeler Adrien , Kavaka Vladyslav , Kolbenschlag Jonas , Steiner Dominik , Storz Anna , Hoffmann Sebastian 
Published: February 2025

Background: Radiation-associated angiosarcoma of the breast (RAASB) is a rare secondary angiosarcoma that typically develops subsequent to breast-conserving therapy for breast cancer. The parameters of the resection width and depth remain the subject of considerable controversy. More recent data indicate that radical resection of the complete radiation field at the thorax is associated with improved local control and survival. Objectives: The present study investigates the radical resection technique of the entire radiation field and subsequent defect coverage in RAASB, as well as the medium-term follow-up. Design: Monocentric, retrospective, and non-comparative study. Methods: From January 2017 to January 2024 a total of 10 patients with RAASB were treated at our hospital. The radical resection technique was employed in the treatment of all patients, encompassing the entire radiation field. Three patients received local flaps (two of whom received vertical and transversal rectus abdominis muscle flaps and one received a local random pattern flap), while the remaining seven were treated with split-thickness skin grafts for defect coverage. Results: The median age at initial diagnosis of breast cancer was 59.3 ± 9.41 years, while that of RAASB was 66.2 ± 8.32 years. The median latency period between the start of irradiation of the chest wall and the initial presentation of RAASB was 6.5 ± 3.08 years. The cumulative median total radiation dose was 57.23 ± 8.34 Gray (cumulative Gray) in 9 of the 10 patients. The overall survival (OS) was 80% in the cohort, with a median follow-up period of 40.0 ± 27.96 months. Three patients exhibited local relapses following radical resection, with two of these patients ultimately succumbing to their condition. Conclusion: Patients with RAASB may benefit from a radical resection of the entire radiation field. Despite the relatively mutilating nature of the procedure, the radical resection technique may have the potential to reduce the rate of local recurrence and prolong OS.
Impact of dipeptidyl peptidase-4 inhibitors on incidence of colorectal cancer in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Fu Rongrong , Chen Jingqi , Fang Yingying , Wu Qingping , Zhang Xiaoming , Wang Zhiyan 
Published: February 2025

Background: The association between dipeptidyl peptidase-4 inhibitors (DPP-4i) exposure and the risk of colorectal cancer (CRC) in patients with type 2 diabetes mellitus (T2DM) is unclear. Objectives: This meta-analysis aims to investigate the relationship between DPP-4i exposure and the incidence of CRC in patients with T2DM. Design: A systematic review and meta-analysis. Methods: A comprehensive search of electronic databases, including PubMed, Web of Science, EMBASE, and ScienceDirect, was conducted up to March 2024. The studies including randomized clinical trials (RCTs), cohort studies, and case–control studies were retrieved. The odds ratio (OR) was calculated using Stata 12.0 statistical software. The primary outcome assessed was the incidence of CRC. Results: This meta-analysis incorporated six retrospective cohort studies and two case–control studies. The findings indicate that the incidence of CRC in the DPP-4i exposure group was significantly higher than that in the control group (OR = 1.11, 95% CI: 1.02–1.21, p = 0.013). Subgroup analysis revealed that both male (OR = 2.07, p < 0.001) and female participants (OR = 1.49, p = 0.05) in the DPP-4i exposure group exhibited a significantly higher incidence of CRC compared to the control group. Among participants younger than 65 years, the incidence of CRC was markedly elevated in the exposure group (OR = 2.81, p < 0.001). Furthermore, when the exposure duration was less than 1 year, the CRC incidence in the exposure group surpassed that of the control group (OR = 1.24, p = 0.005). When sulfonylureas (SU) were used as control drugs, the incidence of CRC was higher in the exposure group (OR = 1.10, p = 0.017). Conclusion: There is a potential correlation between DPP-4i exposure and increased incidence of CRC in T2DM patients. This association appears to be influenced by gender, age, duration of exposure, and the choice of control medications. Therefore, attention should be paid to colorectal diseases when DPP-4i is employed in the clinic. Trial registration: The meta-analysis has been registered with the International Prospective Register of Systematic Reviews (PROSPERO). The registration number is CRD42024535292.
Differences in the Association Between Medial Meniscus Tears and Focal Cartilage Lesions According to Tear Configuration
Authors: Jeon Taehyeon , Kim Jong-Min , Lee Bum-Sik , Bin Seong-Il , Lee Jongjin , Bae Kinam , Kim Donghyok 
Published: February 2025

Background: There are no statistical analyses on the association between the configuration of medial meniscus tears and the location of focal cartilage lesions. Purpose: To investigate the association between the configuration of medial meniscus tears and focal cartilage lesions and analyze whether the location of medial meniscus tears corresponds with that of focal cartilage lesions. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The authors retrospectively evaluated the medical records of 317 patients with isolated medial meniscus tear who underwent arthroscopic surgery from January 2016 to December 2020. The configuration of the medial meniscus tear was determined based on the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) classification. Patients with flap, radial, and longitudinal tears were included in the vertical tear group. For subgroup analysis, vertical tears were divided into medial meniscus posterior root tears and remaining tears. The location of the medial meniscus tear was categorized as anterior, middle, or posterior according to the ISAKOS classification. The cartilage of the medial femoral condyle (MFC) and that of the medial tibial condyle (MTC) were divided into 6 and 4 zones, respectively, and the location of cartilage lesions on the MFC and MTC was evaluated by preoperative magnetic resonance imaging. Results: There was a higher incidence of focal cartilage lesions with vertical versus horizontal medial meniscus tears ( P < .001). For middle and posterior vertical tears with focal cartilage lesions, there was a significant concordance in location between the tear and the lesion ( P < .001). In a subgroup analysis of medial meniscus posterior root tears, there was significantly more discordance in location between the tear and the lesion with medial meniscus posterior root tears (23/26 tears; 88.5%) compared with the remaining vertical tears (60/177 tears; 33.9%) ( P < .001); instead, the focal cartilage lesions were mainly distributed in the lateral anterior and central portions of both the MFC and MTC. Conclusion: Vertical tears of the medial meniscus were significantly associated with the presence of focal cartilage lesions, whereas horizontal tears were not. Additionally, middle and posterior vertical tears with focal cartilage lesions showed significant concordance in location between the tear and the lesion.
Global Longitudinal Strain Imaging in Detection of Subclinical Left Ventricular Systolic Dysfunction in Patients with Asymptomatic Severe Aortic Stenosis
Authors: Dinaraj Arun , Radhakrishnan V.V. 
Published: February 2025

Introduction Left ventricular (LV) hypertrophy and high filling pressure in severe aortic stenosis (AS) cause impairment in coronary flow reserve. This results in LV myocardial ischemia, resulting in impairment in longitudinal shortening. Aim To study the role of LV global longitudinal systolic strain (LVGLS) imaging in identifying subclinical LV dysfunction and to determine the correlation between LVGLS and N-terminal pro-B-type natriuretic peptide (NT pro-BNP) in asymptomatic patients having severe AS and preserved left ventricle ejection fraction. Methodology This study included 33 asymptomatic patients with severe AS and 30 age- and sex-matched control groups. The ejection fraction was measured using the modified Simpson technique. LVGLS was measured with a two-dimensional speckle tracking analysis on apical 2, 3, and 4 chamber views. Results LVGLS was significantly reduced in asymptomatic severe aortic stenosis with normal ejection fraction compared to the normal control group without aortic stenosis ( P < .001). There is a positive correlation between impairment of LVGLS and left ventricular mass index (LVMI), the pressure gradient across the aortic valve, and the valve area. There is a linear correlation between NT pro-brain natriuretic peptide (BNP) and LVGLS ( r value 0.447); as the LVGLS decreases, NT pro-BNP increases. Conclusion LVGLS can be used as a reliable indicator for the detection of subclinical LV dysfunction in asymptomatic severe aortic stenosis patients with preserved ejection fraction.
Pharmacogenomics-based subtype decoded implications for risk stratification and immunotherapy in pancreatic adenocarcinoma
Authors: Zhou Xing , Ba Yuhao , Xu Nuo , Xu Hui , Zhang Yuyuan , Liu Long , Weng Siyuan , Liu Shutong , Xing Zhe , Chen Shuang , Luo Peng , Wang Libo , Han Xinwei 
Published: February 2025

Abstract

Background
With fatal malignant peculiarities and poor survival rate, outcomes of pancreatic adenocarcinoma (PAAD) were frustrated by non-response and even resistance to therapy due to heterogeneity across clinical patients. Nevertheless, pharmacogenomics has been developed for individualized-treatment and still maintains obscure in PAAD.

Methods
A total of 964 samples from 10 independent multi-center cohorts were enrolled in our study. With drug response data from the profiling of relative inhibition simultaneously in mixtures (PRISM) and genomics of drug sensitivity in cancer (GDSC) databases, we established and validated multidimensionally three pharmacogenomics-classified subtypes using non-negative matrix factorization (NMF) and nearest template prediction (NTP) algorithms, separately. The heterogenous biological characteristics and precision medicine strategies among subtypes were further investigated.

Results
Three pharmacogenomics-classified subtypes after stable and reproducible validation, distinguished in six aspects of prognosis, biological peculiarities, immune landscapes, genomic variations, immunotherapy and individualized management strategies. Subtype 2 was close to immunocompetent phenotype and projected to immunotherapy; Subtype 3 held most favorable outcomes and metabolic pathways distinctively, promising to be treated with first-line agents. Subtype 1 with worst prognosis, was anticipated to chromosome instability (CIN) phenotype and resistant to chemotherapeutic agents. In addition, ITGB6 contributed to subtype 1 resistance to 5-fluorouracil, and knockdown of ITGB6 enhanced sensitivity to 5-fluorouracil in in vitro experiments. Ultimately, appropriate clinical stratified treatments were assigned to corresponding subtypes according to pharmacogenomic transcripts. Some limitations were not taken into account, thus needs to be supported by more research.

Conclusion
A span-new molecular subtype exploited for PAAD uncovered an insight into precise medication on ground of pharmacogenomics, and highly refined multiple clinical management strategies for specific patients.
Knowledge, Attitudes, and Practices of General Physicians towards Mild Cognitive Impairment amidst an evolving era of Interprofessional Collaboration: Insights from a small-scale survey in India
Authors: Soni Aarushi , Carthik Prajith , Kumar Devara Manoj , Rooha Aysha , Bajaj Gagan , Moolambally Sheetal Raj , Shirali Arun , Boloor Archith 
Published: February 2025

Abstract

Background
Early identification and intervention of Mild Cognitive Impairment (MCI), led by General Physicians (GPs), can delay dementia onset and enhance patient outcomes. GPs recognize MCI risk factors, conduct assessments, and manage associated conditions, playing a crucial role in cognitive pathology intervention, especially in the era of Interprofessional Collaboration (IPC). In India, where cognitive impairment rates are projected to rise sharply, understanding GPs’ knowledge, attitudes, and practices (KAP) is vital. This study aimed to investigate the KAP of GPs regarding the diagnosis and treatment of MCI using a customized, predesigned questionnaire.

Method
The study employed a cross-sectional design using a convenience sample of 180 invited participants between July and October 2023. A customized questionnaire, based on Lu et al., 2022, evaluated GPs’ KAP regarding MCI and IPC in the Indian context towards its assessment and management. The tool including 9 knowledge items, 15 attitude items, and 12 practice items, was made available through Google Forms and disseminated via WhatsApp. Responses were scored to indicate KAP levels, with maximum scores being 50 for knowledge, 75 for attitudes, and 60 for practices.

Results
103 GPs completed the survey, showing varied practice experience. The average knowledge score was 28.1 ± 7.98, indicating uncertainty about MCI-related factors and diagnostic criteria. Attitude scores averaged 53.5 ± 4.73, with most GPs endorsing early detection and non-pharmacological interventions. Practice scores averaged 41.8 ± 8.32, showing mixed adherence to screening and referral practices. Most participants found IPC highly effective for MCI diagnosis and management, with many referring patients to specialists for confirmation, while over half used an IPC approach for both. Education level and previous experience significantly influenced knowledge and practice scores.

Conclusion
This study sheds light on the evolving landscape of Indian GPs’ KAP related to MCI assessment and management. It identifies areas where understanding could be strengthened and highlight opportunities for growth through education and training. Notably, there is a need for increased involvement in IPC. These findings emphasize the importance of holistic approaches, advocating for enhanced education and the fostering of collaborative relationships across disciplines to tackle the rising prevalence of MCI in India effectively.
Predictors of subjective memory functioning in young adults
Authors: Csábi Eszter , Kovács Fanni Mercédesz , Volosin Márta 
Published: February 2025

Abstract

Background
The characteristics of subjective memory and the underlying cause of subjective memory complaints are well-established in the older population, but less is known about memory functioning and self-perceived memory deficiency in young adults. Therefore, we aimed to investigate the potential contributing factors of subjective memory complaints in young adults, such as objective cognitive performance, negative affective state, well-being and subjective sleep quality.

Methods
125 participants over the age of 18 years were recruited in the study (average age was 21 years (SD = 2.29), 58 males and 67 females, average education of the participants was 14.1 years (SD = 1.94). We measured subjective memory with Multifactorial Memory Questionnaire and different cognitive domains (such as short- and long-term verbal and visual memory, working memory, and executive functions), negative affective states (depression and anxiety), well-being, and subjective sleep quality.

Results
Our results showed that depression had a significant predictive value on satisfaction with memory and subjective memory complaints. We failed to find a relationship between perceived subjective memory functioning and objective cognitive performance. Besides anxiety, only the executive functions predicted significantly the frequency of internal strategy use.

Conclusion
In conclusion, we revealed that negative affective states are more pronounced in the satisfaction with memory and subjective memory complaints in young adults than the objective cognitive ability.
Access to diagnostic testing for invasive fungal diseases and other opportunistic infections in Mexican health care centers caring for patients living with HIV
Authors: Corzo-Leon Dora E. , Martinez-Rivera Nancy , Martin-Onraet Alexandra , Piñeirua-Menendez Alicia 
Published: February 2025

Summary

Background
The burden of opportunistic infections (OIs) remains high among people living with HIV (PLWH) in Mexico, despite improvements in mortality worldwide.

Objective
Reporting the current access to diagnostics of OIs in Mexican Health Care Centers offering health-care services to PLWH.

Methods
An online questionnaire was sent to public health care facilities providing HIV care in Mexico. We evaluated capacities to 1) identify individuals with advanced-HIV, and 2) local and/or on-site access to: point-of-care assays, imaging studies, histological analysis, and microbiology tests useful to diagnose a wide variety of OIs.

Results
In 2022, 46 centers answered the questionnaire, from 23/32 (71.8%) states of the country; 29 (63%) were primary care facilities, 5 (11%) general hospitals and 12 (26%) tertiary care hospitals, providing health services to 67,000 PLWH. These centers received 1,135 new patients/month, 48% with advance disease. Less than 50% could determine CD4 + T cell count (39%, N = 18), toxoplasma serology (41%, N = 19) and HIV viral load (41%, N = 19). Twenty-five centers could diagnose cryptococcosis and tuberculosis (54%). Meanwhile, 11 centers (24%) had access to aspergillosis or Histoplasma tests. Seven centers (11%) had access to coccidioidomycosis tests, five centers to any Pneumocystis diagnosis. In primary care centers, Mycobacterium tuberculosis complex GeneXPert was accessible in 41%, cryptococcal antigen by latex agglutination was available in one facility (3%), Indian ink in 9 centers (31%). No primary health center had access to lateral flow test for Cryptococcus or Histoplasma antigens.

Conclusions
In Mexico, most public HIV-dedicated health care centers lack on-site capacity to diagnose opportunistic infections, specifically fungal infections. Rapid tests and point-of-care tests are frequently unavailable, which is more pronounced in primary care centres. Considering that IFDs still contribute significantly to mortality among PLWH, better access to diagnostic tools in all levels of HIV-care is urgent.