bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between wettability of pulp fibers and tensile strength of paper during recycling
Authors: Jin Hailan , Kose Ryota , Akada Nobushige , Okayama Takayuki 
Published: January 2022

AbstractThe wettability of the paper surface is greatly affected by the wettability of the pulp fibers. We conducted this study in order to understand the relationship between the wettability of a single fiber of recycled pulp and the strength of recycled paper, as well as the inter-fiber bonding strength. The contact angle was determined from a series of photographs of the pulp fiber and the water silhouettes at the point of contact. The contact line and profile history were continuously photographed in every 1 s after the initial contact. The recycled softwood kraft pulp fibers were clearly much less hydrophilic than the original fibers, regardless of whether the fibers had been bleached or not. The contact angle of the original chemi-thermomechanical pulp fiber was much higher than that of the original softwood bleached kraft pulp fiber. Furthermore, increased number of recycling decreased the contact angle of the chemi-thermomechanical pulp fiber. The Page equation was used to evaluate the strength contributions of single fiber and fiber–fiber bonding to tensile strength of paper. As a result, an increase in weakness factor of fiber–fiber bonding strength was obtained for the recycled softwood kraft pulp handsheet. On the other hand, the weakness factor of the original chemi-thermomechanical pulp handsheet decreased with recycling. In addition, the weakness factor of fiber–fiber bonding strength and the contact angles of the provided softwood bleached kraft pulp fibers bore a proportional relationship to each other.
Species characteristics and cultural value of stone wall trees in the urban area of Macao
Authors: Chen Meisi , Huang Songyi , Chen Zheng , Xing Yemiao , Xing Fuwu , Leong KunFong , Yang Yaonan , Qiu Yuan , Qin Xinsheng 
Published: January 2022

AbstractThe stone walls remaining in the highly urbanized Macao area provide a special habitat for plants, repair the fragmentation of the habitat caused by urbanization, and enhance the urban biodiversity. The main object of this survey are stone wall trees in Macao. The species composition, frequency of occurrence and distribution were ascertained, and the feasibility of establishing stone wall tree landscape trail systems was discussed. The results showed that there were 96 stone wall trees in Macao. Among them, 47.9% of the total in the historical center of Macao. In addition, research and analysis on the species composition, life form, frequency and similarity of the associated plants of stone wall trees were analyzed. The survey found that there were 101 species of companion plants, and herbaceous plants had the greatest growth advantage. Most of the companion species were selective and incidental to the stone wall habitat; the similarity of the companion plants in different habitats was less than 0.25, showing that the stone wall was conducive to species diversity. The results of this research aim to explore planning strategies for holistic conservation of stone wall landscape, and provide a theoretical basis for studying the biodiversity of special habitats in Macao.
Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
Authors: Shinohara Issei , Kataoka Takeshi , Mifune Yutaka , Inui Atsuyuki , Sakata Ryosuke , Nishimoto Hanako , Yamaura Kohei , Mukohara Shintaro , Yoshikawa Tomoya , Kato Tatsuo , Furukawa Takahiro , Matsushita Takehiko , Kuroda Ryosuke 
Published: January 2022

AbstractTendon rupture and nerve injury cause fatty infiltration of the skeletal muscle, and the adipokines secreted from the infiltrated adipocytes are known to contribute to chronic inflammation. Therefore, in this study, we evaluated the effects of the adipokines on chronic inflammation using a rat sciatic nerve-crushed injury model. In vitro and in vivo experiments showed that the expression of adiponectin was decreased (0.3-fold) and the expression of Il6 (~ 3.8-fold) and Tnf (~ 6.2-fold) was increased in the nerve-crushed group compared to that in the control group. It was also observed that the administration of an adiponectin receptor agonist decreased the levels of Il6 (0.38-fold) and Tnf (0.28-fold) and improved cellular viability (~ 1.9-fold) in vitro. Additionally, in the fatty infiltrated skeletal muscle, low adiponectin levels were found to be associated with chronic inflammation. Therefore, the local administration of adiponectin receptor agonists would prevent chronic inflammation.
Metabolome analysis of key genes for synthesis and accumulation of triterpenoids in Wolfiporia cocos
Authors: Zeng GuiPing , Li Zhong , Zhao Zhi 
Published: January 2022

AbstractTriterpenoid, the active ingredient in the dried sclerotia of Wolfiporia cocos, has a variety of pharmacological effects. The focus of this research was the cell engineered bacteria modified for triterpenoid biosynthesis, and we aimed to identify the key genes involved in triterpenoid biosynthesis and their roles. Two monospora strains, H and L, were selected from the sexually propagated progeny of W. coco strain 5.78, and their mycelia were cultured for 17, 34, and 51 days. Metabolite analysis showed that there were significantly more down-regulated metabolites of the two strains at three different culture periods than up-regulated metabolites. KEGG indicated that the differential metabolites were mainly concentrated in sterol biosynthesis and ABC transport. STEM analysis suggested that polysaccharide synthesis and accumulation might be greater in the L strain than the H strain. The correlation analysis of DEGs and differential metabolites between the two strain groups showed that erg11 and FDPS, which were closely positively correlated with differential metabolites associated with triterpenoids, were highly expressed in the L strain. This result suggested that the high expression of some genes in the L strain might shunt precursor substances of triterpenoids, which was the possible reason for the decrease in the synthesis and accumulation of triterpenoids.
Fixel based analysis of white matter alterations in early stage cerebral small vessel disease
Authors: Petersen Marvin , Frey Benedikt M. , Mayer Carola , Kühn Simone , Gallinat Jürgen , Hanning Uta , Fiehler Jens , Borof Katrin , Jagodzinski Annika , Gerloff Christian , Thomalla Götz , Cheng Bastian 
Published: January 2022

AbstractCerebral small vessel disease (CSVD) is a common cause of morbidity and cognitive decline in the elderly population. However, characterizing the disease pathophysiology and its association with potential clinical sequelae in early stages is less well explored. We applied fixel-based analysis (FBA), a novel framework of investigating microstructural white matter integrity by diffusion-weighted imaging, to data of 921 participants of the Hamburg City Health Study, comprising middle-aged individuals with increased cerebrovascular risk in early stages of CSVD. In individuals in the highest quartile of white matter hyperintensity loads (n = 232, median age 63 years; IQR 15.3 years), FBA detected significantly reduced axonal density and increased atrophy of transcallosal fiber tracts, the bilateral superior longitudinal fasciculus, and corticospinal tracts compared to participants in the lowest quartile of white matter hyperintensities (n = 228, mean age 55 years; IQR 10 years). Analysis of all participants (N = 921) demonstrated a significant association between reduced fiber density and worse executive functions operationalized by the Trail Making Test. Findings were confirmed by complementary analysis of diffusion tensor metrics.
Sounds of COVID-19: exploring realistic performance of audio-based digital testing
Authors: Han Jing , Xia Tong , Spathis Dimitris , Bondareva Erika , Brown Chloë , Chauhan Jagmohan , Dang Ting , Grammenos Andreas , Hasthanasombat Apinan , Floto Andres , Cicuta Pietro , Mascolo Cecilia 
Published: January 2022

AbstractTo identify Coronavirus disease (COVID-19) cases efficiently, affordably, and at scale, recent work has shown how audio (including cough, breathing and voice) based approaches can be used for testing. However, there is a lack of exploration of how biases and methodological decisions impact these tools’ performance in practice. In this paper, we explore the realistic performance of audio-based digital testing of COVID-19. To investigate this, we collected a large crowdsourced respiratory audio dataset through a mobile app, alongside symptoms and COVID-19 test results. Within the collected dataset, we selected 5240 samples from 2478 English-speaking participants and split them into participant-independent sets for model development and validation. In addition to controlling the language, we also balanced demographics for model training to avoid potential acoustic bias. We used these audio samples to construct an audio-based COVID-19 prediction model. The unbiased model took features extracted from breathing, coughs and voice signals as predictors and yielded an AUC-ROC of 0.71 (95% CI: 0.65–0.77). We further explored several scenarios with different types of unbalanced data distributions to demonstrate how biases and participant splits affect the performance. With these different, but less appropriate, evaluation strategies, the performance could be overestimated, reaching an AUC up to 0.90 (95% CI: 0.85–0.95) in some circumstances. We found that an unrealistic experimental setting can result in misleading, sometimes over-optimistic, performance. Instead, we reported complete and reliable results on crowd-sourced data, which would allow medical professionals and policy makers to accurately assess the value of this technology and facilitate its deployment.
MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells
Authors: Estrada Charlène , Mirabal-Ortega Liliana , Méry Laurence , Dingli Florent , Besse Laetitia , Messaoudi Cedric , Loew Damarys , Pouponnot Celio , Bertolotto Corine , Eychène Alain , Druillennec Sabine 
Published: January 2022

AbstractThe MITF transcription factor and the RAS/RAF/MEK/ERK pathway are two interconnected main players in melanoma. Understanding how MITF activity is regulated represents a key question since its dynamic modulation is involved in the phenotypic plasticity of melanoma cells and their resistance to therapy. By investigating the role of ARAF in NRAS-driven mouse melanoma through mass spectrometry experiments followed by a functional siRNA-based screen, we unexpectedly identified MITF as a direct ARAF partner. Interestingly, this interaction is conserved among the RAF protein kinase family since BRAF/MITF and CRAF/MITF complexes were also observed in the cytosol of NRAS-mutated mouse melanoma cells. The interaction occurs through the kinase domain of RAF proteins. Importantly, endogenous BRAF/MITF complexes were also detected in BRAF-mutated human melanoma cells. RAF/MITF complexes modulate MITF nuclear localization by inducing an accumulation of MITF in the cytoplasm, thus negatively controlling its transcriptional activity. Taken together, our study highlights a new level of regulation between two major mediators of melanoma progression, MITF and the MAPK/ERK pathway, which appears more complex than previously anticipated.
Recollision of excited electron in below-threshold nonsequential double ionization
Authors: Hao Xiaolei , Bai Yuxing , Li Chan , Zhang Jingyu , Li Weidong , Yang Weifeng , Liu Mingqing , Chen Jing 
Published: January 2022

AbstractRecollision is the most important post-tunneling process in strong-field physics, but so far has been restricted to interaction between the first ionized electron and the residual ion in nonsequential double ionization. Here we identify the role of recollision of the second ionized electron in the below-threshold nonsequential double ionization process by introducing a Coulomb-corrected quantum-trajectories method. We will reproduce the experimentally observed cross-shaped and anti-correlated patterns in correlated two-electron momentum distributions, and the transition between them. Both the cross-shaped and anti-correlated patterns are attributed to recolliding trajectories of the second electron. The effect of recollision of the second electron is significantly enhanced by the stronger Coulomb potential of the higher valence residual ion, and is further strengthened by the recapture process of the second electron. Our work paves a potential way to image ultrafast dynamics of atoms and molecules in intense laser field.
Coexistence of carbonyl and ether groups on oxygen-terminated (110)-oriented diamond surfaces
Authors: Chaudhuri Shayantan , Hall Samuel J. , Klein Benedikt P. , Walker Marc , Logsdail Andrew J. , Macpherson Julie V. , Maurer Reinhard J. 
Published: January 2022

AbstractDiamond-based materials have unique properties that are exploited in many electrochemical, optical, thermal, and quantum applications. When grown via chemical vapor deposition (CVD), the growth rate of the (110) face is typically much faster than the other two dominant crystallographic orientations, (111) and (100). As such, achieving sufficiently large-area and high-quality (110)-oriented crystals is challenging and typically requires post-growth processing of the surface. Whilst CVD growth confers hydrogen terminations on the diamond surface, the majority of post-growth processing procedures render the surface oxygen-terminated, which in turn impacts the surface properties of the material. Here, we determine the oxygenation state of the (110) surface using a combination of density functional theory calculations and X-ray photoelectron spectroscopy experiments. We show that in the 0–1000 K temperature range, the phase diagram of the (110) surface is dominated by a highly stable phase of coexisting and adjacent carbonyl and ether groups, while the stability of peroxide groups increases at low temperatures and high pressures. We propose a mechanism for the formation of the hybrid carbonyl-ether phase and rationalize its high stability. We further corroborate our findings by comparing simulated core-level binding energies with experimental X-ray photoelectron spectroscopy data on the highest-quality (110)-oriented diamond crystal surface reported to date.
Allicin suppressed Escherichia coli-induced urinary tract infections by a novel MALT1/NF-κB pathway
Authors: Chang Zhenglin , An Lingyue , He Zhican , Zhang Yuyan , Li Shujue , Lei Min , Xu Peng , Lai Yongchang , Jiang Zheng , Huang Yapeng , Duan Xiaolu , Wu Wenqi 
Published: January 2022

Our experiments revealed that the therapeutic effects of allicin against E. coli induced urinary inflammation were characterized by the restoration of the highly expressed MALT1, the activated AKT/NF-κB pathway, and excessive release of cytokines.
Early Productive Vocabulary Composition as Precursor of Dyslexia
Authors: Maassen Ben A. M. , Krikhaar Evelien , van der Leij Aryan , Fikkert Paula 
Published: January 2022

Purpose:
The aim of this study was to gain more insight into the linguistic characterization of dyslexia by investigating vocabulary acquisition. In a previous study, vocabulary at 17 months of age appeared to be related to familial risk (FR) of dyslexia. The aim of this study was to investigate how the differences in lexical composition further develop up to 3 years (35 months) of age and, more importantly, to what extent these differences can be considered specific precursors of dyslexia later on.

Method:
In a total number of 262 children from the Dutch Dyslexia Program, 169 with and 93 without FR for dyslexia, productive vocabulary was assessed with the Dutch version of the MacArthur Communicative Development Inventories at ages 17, 23, 29, and 35 months. Reading tests were administered in Grades 2 and 3, resulting in dyslexia diagnosis in 60 FR children (FR-dys), leaving 109 FR children who developed normal reading skills (FR-nondys) and 93 control children. Children's expressive vocabulary was scored according to the total number of words produced and according to the different major linguistic word categories: nouns, predicates, and closed-class words. The analyses comprised a comparison of total productive vocabulary and the number of words per grammatical category at four different ages for the three groups (FR-dys, FR-nondys, and control). Also, correlations were calculated between vocabulary scores and reading scores.

Results:
Up to 29 months of age, the total numbers of nouns, predicates, and closed-class words are significantly lower for the FR-dys group as compared with the FR-nondys and control groups; for closed-class words at 23 and 35 months of age, the FR-nondys group's mean values are in between the mean of the FR-dys and control groups. Weak correlations were found between total vocabulary size, number of verbs, number and proportion of predicates at 23 months of age, and word and pseudoword reading fluency in Grades 2 and 3.

Conclusions:
These results indicate that development of vocabulary is a significant though weak predictor of reading fluency and dyslexia; vocabulary size and proportion of verbs at 23 months of age, as well as proportion of closed-class words up to 35 months of age, seem to be the most sensitive indicators of delayed vocabulary development and later reading difficulties. There is no indication that FR for dyslexia by itself is related to vocabulary development.
3D hydrodynamical simulations of the impact of mechanical feedback on accretion in supersonic stellar-mass black holes
Authors: Bosch-Ramon V. 
Published: January 2022

Context. Isolated stellar-mass black holes accrete gas from their surroundings, often at supersonic speeds, and can form outflows that may influence the accreted gas. The latter process, known as mechanical feedback, can significantly affect the accretion rate.
Aims. We use hydrodynamical simulations to assess the impact of mechanical feedback on the accretion rate when the black hole moves supersonically through a uniform medium.
Methods. We carried out three-dimensional (3D) hydrodynamical simulations of outflows fueled by accretion that interact with a uniform medium, probing scales equivalent to and larger than the accretor gravitational sphere of influence. In the simulations, the accretor is at rest and the medium moves at supersonic speeds. The outflow power is assumed to be proportional to the accretion rate. The simulations were run for different outflow-medium motion angles and velocity ratios. We also investigated the impact of different degrees of outflow collimation, accretor size, and resolution.
Results. In general, the accretion rate is significantly affected by mechanical feedback. There is a minor reduction in accretion for outflows perpendicular to the medium motion, but the reduction quickly becomes more significant for smaller angles. Moreover, the decrease in accretion becomes greater for smaller medium-to-outflow velocity ratios. On the other hand, the impact of outflow collimation seems moderate. Mechanical feedback is enhanced when the accretor size is reduced. For a population of black holes with random outflow orientations, the average accretion rate drops by (low–high resolution) ∼0.2 − 0.4 and ∼0.1 − 0.2 for medium-to-outflow velocity ratios of 1/20 and 1/100, respectively, when compared to the corresponding cases without outflow.
Conclusions. Our results strongly indicate that on the considered scales, mechanical feedback can easily reduce the energy available from supersonic accretion by at least a factor of a few. This aspect should be taken into account when studying the mechanical, thermal, and non-thermal output of isolated black holes.
Referral Patterns of Outpatient Palliative Care among the Head and Neck Cancer Population
Authors: Saravia Ari , Kong Keonho Albert , Roy Ryan , Barry Rachel , Guidry Christine , McDaniel Lee S. , Raven Mary C. , Pou Anna M. , Mays Ashley C. 
Published: January 2022

Abstract
Introduction Patients with head and neck cancer (HNC) experience unique physical and psychosocial challenges that impact their health and quality of life. Early implementation of palliative care has been shown to improve various health care outcomes.
Objective The aim of the present study was to evaluate the patterns of referral of patients with HNC to outpatient palliative care as they relate to utilization of resources and end-of-life discussions.
Methods We performed a retrospective review of 245 patients with HNC referred to outpatient palliative care services at two Louisiana tertiary care centers from June 1, 2014, to October 1, 2019. The control group consisted of those that were referred but did not follow-up. Reasons for referral were obtained, and outcome measures such as emergency department (ED) visits, hospital readmissions, and advance care planning (ACP) documentation were assessed according to predictive variables.
Results There were 177 patients in the treatment group and 68 in the control group. Patients were more likely to follow up to outpatient palliative care services if referred for pain management. Hospital system, prior inpatient palliative care, and number of outpatient visits were associated with an increased likelihood for ED visits and hospital readmissions. Those in the palliative care treatment group were also more likely to have ACP discussions.
Conclusion Early implementation of outpatient palliative care among patients with HNC can initiate ACP discussions. However, there are discrepancies in referral reasons to palliative care and continued existing barriers to its effective utilization.
Positive and negative signal and line shape in stimulated Raman spectroscopy: Resonance femtosecond Raman spectra of diphenylbutadiene
Authors: Dobryakov A. L. , Krohn O. A. , Quick M. , Ioffe I. N. , Kovalenko S. A. 
Published: January 2022

Resonance stimulated Raman signal and line shape are evaluated analytically under common electronic/vibrational dephasing and exponential Raman/probe pulse, exp(−|t|/τ). Generally, the signal from a particular state includes contributions from higher and lower electronic states. Thus, with S0 → S1 actinic excitation, the Raman signal consists of 15 Feynman diagrams entering with different signs. The negative sign indicates vibrational coherences in S1 or higher Sn, whereas the positive sign reveals coherences in S0 or Sn via S1 → Sn → Sm (n &lt; m) coupling. The signal complexity is in contrast to spontaneous Raman with its single diagram only. The results are applied to femtosecond stimulated Raman spectra of trans–trans, cis–trans (ct), and cis–cis (cc) 1,4-diphenyl-1,3-butadiene, the ct and cc being reported for the first time. Upon actinic excitation, the Stokes spectra show negative bands from S1 or Sn. When approaching higher resonances Sn → Sm, some Raman bands switch their sign from negative to positive, thus, indicating new coherences in Sn. The results are discussed, and the measured Raman spectra are compared to the computed quantum-chemical spectra.