bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fadenzug von Heißklebstoffen beim Raupenauftrag
Authors: Todorovic Mira , Fürtauer Siegfried , Hoffmann Udo , Burth Dirk , Sängerlaub Sven 
Published: March 2022

AbstractFadenzug ist ein immer wieder vorkommendes, unerwünschtes Phänomen bei Schmelzklebstoffen, die durch Raupenauftrag appliziert werden. Der Fadenzug acht verschiedener Heißklebstoffe für verpackungsrelevante Anwendungen wurde bei verschiedenen Temperaturen und Abständen von Düsenkopf und Trägermaterial sowie mit unterschiedlichen Düsenarten analysiert. Größere Abstände führten in den meisten Fällen zu längeren Fäden. Für den Einfluss der Temperatur und der Viskosität wurden keine eindeutigen Korrelationen gefunden. Die Verwendung von Nadelsitzventilen führte zu weniger Fadenzug im Vergleich zu Kugelsitzventilen. Die Düsengröße hatte keinen Einfluss. Es konnte für alle Klebstoffe eine Kombination von Messbedingungen gefunden werden, bei der kein bzw. kaum Fadenzug auftrat. Erfahrungsgemäß sind diese oft nicht optimal für die Applikation und die Eigenschaften des Klebstoffs.
Mastocytosis presenting with mast cell‐mediator release‐associated symptoms elicited by cyclo oxygenase inhibitors: prevalence, clinical, and laboratory features
Authors: Rama Tiago Azenha , Morgado José Mário , Henriques Ana , Escribano Luis , Alvarez‐Twose Iván , Sanchez‐Muñoz Laura , Moreira André , Romão José , Órfão Alberto , Matito Almudena 
Published: March 2022

AbstractBackgroundNonsteroidal anti‐inflammatory drugs (NSAIDs) are frequently avoided in mastocytosis, because of a potential increased risk for drug hypersensitivity reactions (DHRs) due to inhibition of cyclo‐oxygenase (COX), subsequent depletion of prostaglandin E2 and release of leukotrienes.ObjectivesHere, we aimed at determining the prevalence of mast cell (MC) mediator release symptoms triggered by NSAIDs in mastocytosis patients and the associated clinical and laboratory features of the disease.MethodsMedical records from 418 adults to 223 pediatric mastocytosis patients were retrospectively reviewed. Patients were classified according to tolerance patterns to NSAIDs and other COX inhibitors (COXi) and compared for epidemiological, clinical and laboratory findings.ResultsOverall, 87% of adults and 91% of pediatric patients tolerated NSAIDs and other COXi. Among adult and pediatric patients presenting DHRs, 5% and 0% reacted to multiple NSAIDs, 4% and 0.7% were single reactors, and 3% and 8% were single reactors with known tolerance to paracetamol but unknown tolerance to other COXi, respectively. Among adults, hypersensitivity to ≥2 drugs was more frequent among females (p = 0.009), patients with prior history of anaphylaxis to triggers other than NSAIDs or other COXi and Hymenoptera venom (p = 0.009), presence of baseline flushing (p = 0.02), baseline serum tryptase ≥48 ng/ml (p = 0.005) and multilineage KIT mutation (p = 0.02). In contrast, tolerance to NSAIDs and other COXi was more frequent among males (p = 0.02), in patients with anaphylaxis caused by Hymenoptera venom (p = 0.02), among individuals who had skin lesions due to mastocytosis (p = 0.01), and in cases that had no baseline pruritus (p = 0.006). Based on these parameters, a score model was designed to stratify mastocytosis patients who have never received NSAIDs or other COXi apart from paracetamol, according to their risk of DHR.ConclusionsOur results suggest that despite the frequency of MC mediator related symptoms elicited by NSAIDs and other COXi apart from paracetamol is increased among mastocytosis patients versus the general population, it is lower than previously estimated and associated with unique disease features. Patients that tolerated NSAIDs and other COXi following disease onset should keep using them. In turn, adults with unknown tolerance to such drugs and a positive score should be challenged with a preferential/selective COX‐2 inhibitor, while the remaining may be challenged with ibuprofen.
A new metric for feature selection on short text datasets
Authors: Cekik Rasim , Uysal Alper Kursat 
Published: March 2022

AbstractIn recent years, short texts are everywhere, especially in social media networks. Short text classification is an essential task for various applications related to the operations on short text documents. In many cases, using the entire feature set causes the high dimensionality problem in short text data. This problem reason of time‐consuming and negatively impacts the performance of classifiers. This study presents an effective feature selection algorithm called XY method, which represents the features on XY line and calculates the distance of a feature to the XY line. Also, a value named λ is calculated. According to this value, the terms are divided into different regions such as negative, positive, and third to determine their discrimination capability. The novel XY method aims to select as few terms as possible in the negative region. The proposed method is evaluated using four different short text datasets with Macro‐F1 success measure. In comparisons with other existing feature selection algorithms such as chi‐square, information gain, deviation from Poisson distribution, recently proposed max‐min ratio, and distinguishing feature selector demonstrate that the XY method achieves either better or competitive performance in significantly reduced various feature sizes.
Heterogeneous reconfigurable architectures for machine learning dataflows
Authors: Oliveira Westerley C. , Canesche Michael , Reis Lucas , Nacif José Augusto M. , Ferreira Ricardo S. 
Published: March 2022

AbstractThis work explores the placement and routing of machine learning applications' dataflow graphs on different heterogeneous coarse‐grained reconfigurable architectures (CGRA). We analyze three different types of processing element (PE) heterogeneity, the first concerning the interconnection pattern, the second being on the kind of operations a single PE can execute, and the last concerning the PE buffer resources. This analysis aim to propose a fair reduction to the overall cost in comparison to the homogeneous CGRA architecture. We compare our results with the homogeneous case and one of the state‐of‐the‐art tools for placement and routing (P&R). Our algorithm executed, on average, 52% faster than VPR 8.1 (Versatile Place and Route), which is an open‐source academic tool designed for the FPGA placement and routing phases, reaching better mapping in 66% of cases and achieving the same results in 26% of cases. Furthermore, a heterogeneous architecture reduces the cost without losing performance in 76% of the cases considering multiplier heterogeneity. We propose a novel heterogeneous buffer architecture that minimizes the buffer resources by 56.3% for K‐means dataflow patterns. We also show that a heterogeneous border chess architecture outperforms a homogeneous one. In addition, our mapping reaches optimal instances of single tree dataflows compared to classical Lee/Choi and H‐trees.
Effect of Electron Donating/Withdrawing Groups on Molecular Photoswitching of Functionalized Hemithioindigo Derivatives: a Computational Multireference Study
Authors: Lea Martin R. , Stavros Vasilios G. , Maurer Reinhard J. 
Published: March 2022

AbstractHemithioindigos are a versatile group of molecules with the ability to undergo double bond isomerisation upon light excitation. Using electronic structure theory, a detailed description of the photoisomerisation of hemithioindigo and five of its functionalized derivatives is reported. We use a combination of Density Functional Theory (DFT), approximate second order Coupled Cluster (CC2), and multireference methods such as the complete active space self‐consistent field (CASSCF) method to probe how isomerisation capabilities of functionalized hemithioindigo derivatives are affected by functionalisation with both electron donating and withdrawing groups. We demonstrate that important properties such as the thermal barrier, electronic absorption spectra and, to an extent, the mechanism can all show pronounced differences compared to the parent hemithioindigo molecule. Our results demonstrate how the inclusion of functional groups can have important effects on its photoisomerisation capabilities, which in turn, can influence the fate of these molecules upon light excitation and their utility as molecular switches.
How to Build an Image‐Processing Pipeline for Automating Multiparameter Histocytometry Analysis
Authors: Munoz‐Erazo Luis , Schmidt Alfonso J. , Shinko Diana , Price Kylie M. 
Published: March 2022

AbstractUntil relatively recently, analysis of imaging data has been primarily quantitative and limited to 3‐4 markers. The advancement of various technologies overcoming this marker limitation provided the capability of analyzing multiparameter imaging data down to the single cell level, termed histocytometry. Currently, most published end‐to‐end histocytometric analysis of imaging data is performed using expensive commercial programs or freely available analysis packages that require significant knowledge of programming languages for execution. Here we present a protocol that performs cell segmentation, phenotyping and spatial analysis, using software with easy‐to‐use GUIs (graphical user interfaces). These protocols allow the user to derive spatial and phenotypical data for the analysis of multiparameter microscopic images from most imaging platforms in a low‐cost manner. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Cell Segmentation and generation of histocytometric .csv fileBasic Protocol 2: Phenotyping of cell populationsBasic Protocol 3: Spatial relationship analyses of phenotyped populationsSupport Protocol 1: Nuclei Segmentation Accuracy TestSupport Protocol 2: Correcting y‐axis Inversion of Histocytometry Data Relative to Original Image File
Fund managers acting as impact investors: Strategies, practices, and tensions
Authors: Bandini Federica , Chiappini Helen , Pallara Francesca 
Published: March 2022

AbstractUsing a multi case‐study analysis, we shed light on the strategies, practices, and tensions of fund managers acting as impact investors. Results show that while some fund managers experience tension between the social and financial aspects of specific, although relevant, components of the business model, other fund managers experience challenges throughout the business model. The governance component emerges as the most relevant issue and this may help explain why impact washing is a key topic in the impact investing discussion. Relevant implications for practitioners and policy makers are also discussed.
Program death ligand‐1 immunocytochemistry in lung cancer cytological samples: A systematic review
Authors: Satturwar Swati , Girolami Ilaria , Munari Enrico , Ciompi Francesco , Eccher Albino , Pantanowitz Liron 
Published: March 2022

AbstractIn this era of personalized medicine, targeted immunotherapies like immune checkpoint inhibitors (ICI) blocking the programmed death‐1 (PD‐1)/program death ligand‐1 (PD‐L1) axis have become an integral part of treating advanced stage non‐small cell lung carcinoma (NSCLC) and many other cancer types. Multiple monoclonal antibodies are available commercially to detect PD‐L1 expression in tumor cells by immunohistochemistry (IHC). As most clinical trials initially required tumor biopsy for PD‐L1 detection by IHC, many of the currently available PD‐1/PD‐L1 assays have been developed and validated on formalin fixed tissue specimens. The majority (>50%) of lung cancer cases do not have a surgical biopsy or resection specimen available for ancillary testing and instead must rely primarily on fine needle aspiration biopsy specimens for diagnosis, staging and ancillary tests. Review of the literature shows multiple studies exploring the feasibility of PD‐L1 IHC on cytological samples. In addition, there are studies addressing various aspects of IHC validation on cytology preparations including pre‐analytical (e.g., different fixatives), analytical (e.g., antibody clone, staining platforms, inter and intra‐observer agreement, cytology‐histology concordance) and post‐analytical (e.g., clinical outcome) issues. Although promising results in this field have emerged utilizing cytology samples, many important questions still need to be addressed. This review summarizes the literature of PD‐L1 IHC in lung cytology specimens and provides practical tips for optimizing analysis.
Influence of catheter ablation for atrial fibrillation on atrial and ventricular functional mitral regurgitation
Authors: Masuda Masaharu , Sekiya Kimiko , Asai Mitsutoshi , Iida Osamu , Okamoto Shin , Ishihara Takayuki , Nanto Kiyonori , Kanda Takashi , Tsujimura Takuya , Matsuda Yasuhiro , Hata Yosuke , Uematsu Hiroyuki , Toyoshima Taku , Higashino Naoko , Mano Toshiaki 
Published: March 2022

AbstractAimsThe purpose of this study was to compare the impact of catheter ablation on cardiac structural reverse remodelling and atrial (AFMR) and ventricular (VFMR) functional mitral regurgitation (MR), and the long‐term prognosis of patients with AFMR and VFMR.Methods and resultsThe retrospective study included persistent AF patients who had AFMR (n = 136, left atrial (LA) volume index >30 mL/m2 and left ventricular (LV) ejection fraction ≥40%) or VFMR (n = 31, LV ejection fraction <40% or LV regional asynergy) and had undergone the initial AF ablation from April 2015 to December 2019. Baseline and 6 month follow‐up echocardiography were performed to assess MR, LA, and LV sizes. MR improvement after ablation was comparable in the AFMR (64%) and VFMR groups (52%, P = 0.20). Patients with AFMR improvement showed a greater decrease in left atrial volume after ablation than those without (amount of change: −11.4 ± 15.1 vs. −2.3 ± 21.1 mL/m2, P = 0.01). Patients with VFMR improvement showed a greater increase in LV ejection fraction than those without (amount of change: 28.5 ± 13.6% vs. 9.0 ± 14.8%, P = 0.001). The composite endpoint of all‐cause death and heart failure hospitalization during the 2 year follow‐up period was more frequently observed in the VFMR than in the AFMR group (22.6% vs. 3.7%, P < 0.0001). Patients with MR improvement after catheter ablation less frequently demonstrated the composite endpoint than those without (1.9% vs. 15.6%, P < 0.0001).ConclusionsAtrial functional mitral regurgitation and VFMR improvement after ablation were associated with atrial and ventricular reverse remodelling, respectively. It is possible that long‐term prognosis is better in patients with AFMR than with VFMR, and in those with MR improvement than in those without.
The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from CHAMP‐HF
Authors: DeVore Adam D. , Hellkamp Anne S. , Thomas Laine , Albert Nancy M. , Butler Javed , Patterson J. Herbert , Spertus John A. , Williams Fredonia B. , Shen Xian , Hernandez Adrian F. , Fonarow Gregg C. 
Published: March 2022

AimsWe assessed for an association between improvements in left ventricular ejection fraction (LVEF) and future outcomes, including health status, in routine clinical practice.Methods and resultsCHAMP‐HF was a registry of outpatients with heart failure (HF) and LVEF ≤40%. Enrolled participants completed the Kansas City Cardiomyopathy Questionnaire‐12 (KCCQ‐12) at regular intervals and were followed as part of routine care. We assessed for associations between improvements in LVEF (≥10%) over time and concurrent changes in KCCQ‐12, as well as the subsequent risk of poor outcomes. We included 2092 participants in the study. They had the following characteristics: median age 67 years (25th–75th percentile 58–75), 29% female, median duration of HF 2.7 years (0.6–6.8), and median baseline LVEF 30% (23–35). Of the study participants, 689 (33%) had a ≥10% absolute improvement in LVEF. Participants with an LVEF improvement also had an improvement in KCCQ‐12 overall summary score compared with participants without an LVEF improvement (+7.6 vs. +3.5, adjusted effect estimate +4.01 [95% confidence interval CI 2.3–5.7]). Similarly, subsequent all‐cause death or HF hospitalization occurred in 12% in the LVEF improvement group versus 25% in the group without an LVEF improvement (adjusted hazard ratio 0.50, 95% confidence interval 0.41–0.61).ConclusionIn a large cohort of outpatients with chronic HF, improvements in LVEF were associated with improved health status and a reduced risk for future clinical events. These data underscore the importance of improvement in LVEF as a treatment target for medical interventions for patients with chronic HF.
Palladium(II)‐Catalyzed Direct Arylations of Quinoxalin‐2(1H)‐ones with Arylsulfonyl Chlorides
Authors: Nale Sagar D. , Datta Khanal Hari , Rok Lee Yong 
Published: March 2022

AbstractA palladium‐catalyzed desulfitative coupling of quinoxalin‐2(1H)‐ones with arylsulfonyl chlorides is described. C3‐Arylquinoxalin‐2(1H)‐ones are readily accessible by reacting various arylsulfonyl chloride derivatives with quinoxalin‐2(1H)‐ones. The arylsulfonyl chloride undergoes palladium‐catalyzed C−S and S−Cl bond cleavage, which leads to direct desulfitative cross‐coupling with the quinoxalin‐2(H)‐one. Chloro‐ and fluoro‐aryl sulfonyl chlorides are successfully coupled with quinoxalin‐2(1H)‐ones without carbon–halogen bond cleavage.
Efficacy and safety of botulinum A toxin for the treatment of chronic peripheral neuropathic pain: A systematic review of randomized controlled trials and meta‐analysis
Authors: Hary Vincent , Schitter Sebastien , Martinez Valeria 
Published: March 2022

AbstractBackground and ObjectiveBotulinum toxin type A (BTX‐A) is a recently developed treatment for the management of peripheral neuropathic pain. The objective of this study was to provide a synthesis of the evidence concerning the efficacy and safety of subcutaneous botulinum toxin type A injections.Databases and Data TreatmentWe searched the MEDLINE, EMBASE, LILACS, Cochrane, and Clinical Trial Register databases for randomized controlled trials comparing subcutaneous BTX‐A to placebo injections for treating chronic peripheral neuropathic pain. The primary endpoint was the assessment of pain 1 month after the injection. The secondary outcomes were the assessment of pain at 3 months, neuropathic pain intensity and quality of life at 1 and 3 months, and adverse effects. A random‐effect meta‐analysis was performed on the combined data. Evidence quality was rated by the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) method.ResultsTen randomized controlled trials including 505 patients were included in this review (registration number CRD42021239108). At 1 and 3 months after injection, the BTX‐A groups had a lower mean difference (MD) in pain score (MD −1.87 (confidence intervals [CIs] −2.91; −0.83) and −1.38 (CI −1.95; −0.81), respectively). Subgroup analysis showed greater efficacy for diabetic polyneuropathy (MD −2.48, [−3.22; −1.74]). We found no impact of BTX‐A on quality of life and no difference in adverse effect between BTX‐A and placebo. The evidence was considered of moderate quality.ConclusionThe pooled data suggest that subcutaneous BTX‐A injections have a clinically significant effect, decreasing pain for three months after the injection, but no benefit in terms of quality of life has yet been demonstrated.SignificanceWe found that botulinum toxin is efficient and safe for the treatment of neuropathic pain, especially for diabetic polyneuropathy. Botulinum toxin type A, used for years in neurology, rehabilitation and physical medicine, has proved innocuous and effective, and should be considered as a serious alternative for pain treatment.
Electrochemiluminescence DNA Biosensor for HBV Based on Coralloid Poly(Aniline‐Luminol)‐MWCNTs and Catalysis of Ferrocene
Authors: Dong Ruirui , Zhang Yanhui , Huang Jiali , Habibul Marhaba , Li Guixin 
Published: March 2022

AbstractA novel electrochemiluminescence biosensor was presented for the assay of hepatitis B virus (HBV) DNA. Coralloid poly(aniline‐luminol)‐MWCNTs was prepared on an electrode surface, which was followed by the attachment of capture DNA via amide bond formation. The HBV‐DNA and ferrocene labelled DNA hybridized with capture DNA to form a sandwich structure on electrode surface. Ferrocene can effectively increase the signal output of the ECL sensor due to the catalysis of ferrocene on electrochemiluminescence of luminol. The biosensor rendered a linear dependence over the range from 1.0×10−16 to 1.0×10−7 M with a low detection limit of 2.4×10−17 M.
Electrochemical hydrogen generation technology: Challenges in electrodes materials for a sustainable energy
Authors: Inocêncio Carlos V. M. , Holade Yaovi , Morais Claudia , Kokoh K. Boniface , Napporn Teko W. 
Published: March 2022

AbstractForesee advanced and innovative strategies is a key approach and constitutes a cornerstone for accessing clean, affordable, and reliable energy to satisfy the world's increasing prosperity and economic growth. To this end, hydrogen energy technologies parade as promising sustainable solutions to the looming energy crisis at either the small or large industrial scale, which will enable to reduce significantly our dependence on conventional energy sources based on fossil fuels without increasing atmospheric CO2 levels. Water electrolysis with renewable energy is one of the best solutions to produce hydrogen without COx (CO and CO2) emissions. However, the practical realization of this elegant opportunity of paramount importance is facing several challenges, among which are: (i) the efficient design of cathode and anode catalytic materials exhibiting improved intrinsic and durable activity; (ii) the scale‐up of the system for the large‐scale hydrogen production through the electrochemical water splitting. This review puts these opportunities and challenges into a broad context, discusses the recent research and technological advances, and finally provides several pathways and guidelines that could inspire the development of groundbreaking electrochemical devices for hydrogen production. It also points out the materials design and preparation for the efficient electrochemical production of the molecular hydrogen in acidic and alkaline environments, from a simple electrolytic solution to the water splitting reaction, which is also considered in the process. Furthermore, the main technology keys for designing a reliable electrochemical system will be noticed.