bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of using EpiTapp application in structural focal epilepsy
Authors: Narodova E. A. , Shnayder N. A. , Karnaukhov V. E. , Narodova V. V. 
Published: January 2022

Background. Non-pharmacological methods of palliative therapy for structural focal epilepsy (SFE) have been extensively investigated. Development of self-care methods based on behavioral psychotherapy and reference bioadaptation is a promising and economically justified approach.Objective: to present a clinical case of administering EpiTapp application based on the author-proposed wrist tapping method for palliative care in adult SFE.Material and methods. The author-proposed method of wrist tapping (RF patent No. 2606489 of 01.10.2017) for a smartphone Android OS application was used. Wrist tapping was performed during the period of aura and/or focal seizures (FS) in patients with SFE. Patients used the smartphone application as an element of emergency palliative therapy for SFE outpatient settings.Results. Patient L., 33 years old, suffering from SFE with frequent FS and bilateral seizures (BS), received duotherapy in the preoperative period. The woman used the EpiTapp application regularly that allowed to reduce FS rate by 65%, as well as prevent BS development without altering the antiepileptic therapy regimen.Сonclusion. The experience of using the EpiTapp application based on the author-proposed method of wrist tapping has demonstrated that it holds promise for SFE palliative therapy. The proposed technique requires additional research to confirm its effectiveness.
Flying the Rainbow Flag at the United Nations
Authors: Sanders Douglas 
Published: January 2022

Issues of sexual orientation and gender identity were raised in two of the United Nations intergovernmental world conferences on women, 1985 and 1995, and in the Vienna world conference on human rights in 1993. From 2006 a number of LGBTI Non-Governmental Organizations gained ongoing ‘consultative status’ from the Economic and Social Council allowing access to regular UN human rights events. Leading human rights NGOs, such as Amnesty International and Human Rights Watch began to address LGBTI issues. The Human Rights Council condemned violence and discrimination on grounds of sexual orientation and gender identity in 2011 and later authorized an independent expert, whose mandate was renewed for a second term. The UNDP “Being LGBT in Asia” program has been active in eight Asian states, including five in ASEAN: Cambodia, Indonesia, Philippines, Thailand, and Vietnam. Strong support came from Ban Ki-moon as UN Secretary-General, as well as from the Office of the UN High Commissioner for Human Rights and other agencies.
apropriação das classes nouvelles francesas
Authors: Franco Millena Miranda 
Published: January 2022

O texto do professor Laurent Gutierrez, que será apresentado a seguir, foi publicado no final de novembro de 2019 no primeiro número da revista Futuro do Pretérito, a partir da transcrição da conferência proferida pelo professor Laurent Gutierrez, por ocasião das comemorações de 50 anos de fundação da Faculdade de Educação da Universidade de São Paulo (FEUSP) e 60 anos da fundação da Escola de Aplicação (EA). A revista Futuro do Pretérito, criada em outubro de 2019, por Millena Miranda, então aluna do curso de graduação em Pedagogia da FEUSP, idealizou homenagear o Centro de Memória da Educação - USP, o aniversário de 50 anos da FE-USP e 60 anos da Escola de Aplicação (EA), bem como divulgar atividades de ensino, pesquisa, cultura e extensão universitária. Ao longo dos anos, o projeto complexificou-se e assumiu novos contornos devido à intercomunicação coletiva, ao estudo do contexto histórico, político e social e à diversidade dos sujeitos que passaram a integrar a organização do periódico (FRANCO, M. M.; PAIVA, B. M.; OSTETI, G.R.; SILVA, N. R. P.; SILVA, B. H.; OSTETI, G.R; COSTA, P. S. R., 2021). O link de acesso à publicação é este: http://www4.fe.usp.br/futurodopreterito
Paleoenvironmental Evolution of a Forearc in Response to Forcings by Drainage, Climate, Volcanism, and Tectonics: The Quillagua Depocenter, Chile
Authors: Jordan Teresa , Quezada Andrés , Blanco Nicolás , Jensen Arturo , Vásquez Paulina , Sepúlveda Fernando 
Published: January 2022

Abstract
The Late Miocene and Pliocene Quillagua depocenter lake system existed in a forearc basin on the west side of the Andes Mountains in northern Chile, alternating between standing-water and salar conditions. Quaternary incision of the Loa River Canyon resulted in bypass of the prior depositional surface and drainage of groundwater from the abandoned depocenter. Systematic regional geological mapping, 32 new chronological constraints on the strata in the basin, outcrop-scale facies analyses, and geophysical data underpin a revised evaluation of the controls on the lake system. The progressive stages, ages, and causes of the Quaternary destruction of the lake system are reconstructed based on mapped distributions of superficial fluvial sediments, chronological studies of terrace deposits, and landform analysis. The lake system occurred at the junction of small catchments draining the slowly rising western Andean foothills and the large paleo-Loa River catchment draining the Andean volcanic arc, during a time span of intense caldera activity. Small magnitude climate variability affected both the hyperarid low elevation sectors and arid upper sectors of the catchments. By 10 Ma, the regional climate was extremely arid, limiting water and sediment to small amounts, and during the Late Miocene and Pliocene, there was no surface-water outlet to the Pacific. Hydrological variations from 9 to 2.6 Ma led to sediment accumulation in variable lake environments, alternating with long hiatuses. Minor deformation within the Quillagua depocenter shifted the topographic axis and groundwater outlets. Simultaneous headward erosion from the Pacific shore captured the Loa River, which triggered large-magnitude incision that persists today. The progression of surface water environmental change was accompanied by changing composition and amount of surface and groundwater, which determined deposition of primary evaporite minerals, extensive diagenesis, and eventually, complex patterns of dissolution expressed as karst.
The Physician Assistant/associate Medical Workforce: 2020-2035
Authors: Hooker Roderick S. , Kulo Violet A. , Kayingo Gerald , Jun Hyun-Jin , Cawley James F 
Published: January 2022

Abstract
Background: Physician assistant/associates (PAs) are health care professionals whose roles expand universal access to a broad range of people across many nations. In the US, there is a growing shortage of physicians. PAs and advanced practice registered nurses (APRNs) were developed to help span medical providers' supply and demand gap. A forecasting project was undertaken to predict the likely census of PAs in the medical workforce spanning 2020 to 2035. Methods: Microsimulation modeling of the American PA workforce was performed using standard stock and flow format. The number of clinically active PAs employed in 2020 formed the baseline. Graduation rates and PA program expansion were factored as critical parameters to predict annual growth; attrition estimates balanced the equation. Two models, one based on data from the Bureau of Labor Statistics (BLS) and another based on data from the National Commission on Certification of Physician Assistants (NCCPA), were analyzed to estimate future annual PA numbers. Results: As of 2020, the BLS estimated 125,280 PAs were employed in the medical workforce; the NCCPA estimate was 148,560 PA in active practice. The mean age was 40, and 76% were female. The Accreditation Review Commission accredited 277 PA education programs for the Physician Assistant (ARC-PA), and 99% had a graduating class. The mean annual graduation cohort was 45. The BLS model predicted approximately 204,243 clinically active PAs by 2035; the NCCPA-based model predicted 211,537 PAs in clinical practice. Conclusions: A physician assistant/associate predictive model based on two data sources projects the supply of PAs by 2035 between 204,000 and 212,000: a growth rate of ± 35% (3.5% model differences). If the most likely scenario is realized, the 15-year growth of the PA will help improve the gap in the supply and demand of American medical service.
Structural Investigation, Chemical Durability, And Kinetic Characterization of Sodium-Tungsten-Titanium Phosphate Glasses
Authors: Es-soufi Hicham , Bih L. 
Published: January 2022

Abstract
Solid electrolytes of sodium ions were applied in many technologies, from chemical sensors to batteries. In this work, we focused on the study of electrolytes-based phosphate glasses prepared within the system 20Na2O-(50-x)Na2WO4-xTiO2-30P2O5 (with 0≤x≤25 mol%). These glasses were elaborated via a melt-quenching method. The DSC technique was exploited to estimate the activation energy depending on the crystallization (Ec). Where the glass (x= 5) was characterized by Ec= 144.77 kJ/mol. Avrami parameter (n) allows determining the mechanism of crystallization. This parameter value is found around ≈ 2; it can anticipate that the crystallization mechanism is a one-dimensional, periodic landscape. The Raman spectroscopy analysis showed that the bonds constituting the framework of these glasses are essential constituted from the PO4 units. The insertion of TiO2 into the glass framework leads to formation of the new bonds P-O-Ti and/or Ti-O-Ti. Changing the Na2WO4 mol% by TiO2 mol% leads to switching the structural units Q2 to Q1 units then Q0 units. Obtained results of the durability analysis verified that the dissolution of the explored glasses relies on glassy composition. When TiO2 replaces Na2WO4, durability is increased.
Direct Degradation of Methylene Blue by Unactivated Peroxymonosulfate: Reaction Parameters, Kinetics, and Mechanism
Authors: Zuo Xu , Nie Jianxin , Jiang Beier , Jiang Aijun , Zou Shiyang , Wu Junrong , Ding Bingquan , Wang Xue hui , Liu Yang 
Published: January 2022

Abstract
Advanced oxidation processes (AOPs) are efficient methods for water purification. However, there are few studies on direct oxidation with inactive peroxymonosulfate (PMS) to remove pollutants. In this study, methylene blue (MB) was oxidised efficiently by PMS. MB was decomposed through a non-radical pathway, as verified by the scavengers and electron paramagnetic resonance experiments. Although singlet oxygen was formed, the possibility of it degrading MB was ruled out via kinetics calculations. Therefore, the obvious conclusion was that PMS reacted directly with MB. Additionally, the operating parameters, including PMS dosage, MB dosage, temperature, and initial pH, were investigated. MB degradation followed pseudo-first-order kinetics, with rate constants ranging from 0.0082 to 0.3912 min−1. The second-order rate constant (kPMS,MB) for the reaction of MB with PMS was 0.08 M−1s−1 at pH 3–6, but kPMS,MB increased dramatically to 4.68 M−1s−1 with increasing solution pH. Chloride in the PMS/MB system reacted with PMS to form HClO, which was catalysed by PMS to rapidly decompose MB. Interestingly, MB is effectively mineralised by PMS in the presence of chlorine. In addition, humic acid, a common scavenger, did not inhibit MB degradation. In an alkaline environment, the removal rate of TOC reached 16%, but PMS caused almost no mineralisation of MB in an acidic environment. This study provides new insights into pollutant removal based on AOPs and an additional strategy for water purification.
Human centromere formation activates transcription and opens chromatin fibre structure
Authors: Gilbert Nick , Naughton Catherine , Huidobro Covadonga , Catacchio Claudia , Buckle Adam , Grimes Graeme , Nozawa Ryu-Suke , Purgato Stefania , Rocchi Mariano 
Published: January 2022

Abstract
Human centromeres appear as constrictions on mitotic chromosomes and form a platform for kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive DNA at centromeric regions form a compact scaffold necessary for function, but this was revised when neocentromeres were discovered on non-repetitive DNA. To test whether centromeres have a special chromatin structure we have analysed the architecture of a neocentromere. Centromere formation is accompanied by RNA pol II recruitment and active transcription to form a decompacted, negatively supercoiled domain enriched in ‘open’ chromatin fibres. In contrast, centromerisation causes a spreading of repressive epigenetic marks to surrounding regions, delimited by H3K27me3 polycomb boundaries and divergent genes. This flanking domain is transcriptionally silent and partially remodelled to form ‘compact’ chromatin, similar to satellite-containing DNA sequences, and exhibits genomic instability. We suggest transcription disrupts chromatin to provide a foundation for kinetochore formation whilst compact pericentromeric heterochromatin generates mechanical rigidity.
Prevalence of Computer Vision Syndrome and Patterns of Electronic Devices Usage before and during COVID-19 Pandemic among Medical Students in Riyadh, Saudi Arabia
Authors: Almousa Abdullah , Aldofyan Munirah , Kokandi Bushra , Alsubki Haneen , Alqahtani Rawan , Gikandi Priscilla , Alghaihb Shatha 
Published: January 2022

Abstract
Purpose: To estimate the prevalence of CVS (computer vision syndrome) among university medical students in Riyadh, Saudi Arabia after establishing remote learning during COVID-19 pandemic and to compare patterns and settings of electronic devices used by students before and during this pandemic. Methods: This is an observational descriptive cross-sectional study. 1st to 5th year medical students actively enrolled at the governmental colleges of medicine in Riyadh were asked to fill an electronic online questionnaire. The questionnaire included demographic information and various variables to be studied. Results: A total of 300 medical students were included in this study. 282 (94.0%) reported at least one symptom of CVS. The most frequently reported symptoms were musculoskeletal: neck, shoulder and back pain in 253 (84.3%), headache in 213 (71.1%) and dry eyes in 204 (68%). 38% of the students experienced more severe symptoms while 48% experienced more frequent symptoms during COVID-19 pandemic. The risk factors for experiencing three or more symptoms of CVS were using electronic devices for longer periods (6.8 hours ±2.8) during COVID-19 (p<0.001) OR 1.21 [1.09-1.35] 95% CI, and being of female gender (p<0.001) OR 3.29 [2.00-5.43] 95% CI. Conclusion: CVS prevalence during COVID-19 era among medical students is high. This necessitates increasing the awareness of CVS and its preventive measures.
Information Measures for MADM Underm-Polar Neutrosophic Environment
Authors: Naeem Khalid , Divvaz Bijan 
Published: January 2022

Abstract
Multiploar information plays a vital role in making reliable decisions in one’s daily life encompassing micro to large scale decisions. These decision making problems often include imprecise and inconsistent data. This article presents some information measures including similarity, distance, correlation, divergence and Dice measures for m-polar neutrosophic sets. Desirable characteristics of these measures are also presented. The notions of angle of similarity between two m-polar neutrosophic sets, λ -similarity, entropy and less and more fuzzy are also made part of the discussion. An application of m-polar neutrosophic sets using the suggested measures in health sciences accompanied by five algorithms is also presented. Finally, comparative analysis of the proposed information measures with some existing measures is also presented.
Next of Kin, An Invisible Resource In The Drug Treatment of Nursing Home Residents: A Qualitative Study
Authors: Bell Hege Therese , Vaage Helga 
Published: January 2022

Abstract
Objective: Explore next of kin’s perceptions of the ongoing drug treatment given to nursing home residents, and their perceptions of the collaboration with health personnel at the nursing home. Design, setting and subjects: A qualitative study with ten next of kin to nursing home residents who participated in semi-structured individual interviews in Central and Southern Norway. The data were analysed thematically by using systematic text condensation.Results: Next of kin express a trust towards the drug treatment given, however, the trust is fragile. There was an urge for information and of being in control, not necessarily with the aim to influence treatment but to know what happens to their loved ones. Due to long-lasting knowledge of the resident, they viewed themselves as the resident’s advocate to ensure appropriate drug treatment. The collaboration between health personnel and next-of-kin were scarce and described as an “us-them” relationship. Next of kin perceived having to force an entry for dialogue and of health personnel being inaccessible and invisible.Conclusion: Next of kin want to be informed about the ongoing drug treatment given to the resident, however, information given are scarce and delayed which affect the trust towards health personnel at the nursing home. Input from next of kin could be used to offer person-centered care, however, next of kin perceive their input often being ignored. Implications: Effort must be put to unite expectations and seek a mutual understanding of which role next of kin should hold regarding information and collaboration about the ongoing drug treatment of the nursing home resident.
LncRNA-mRNA expression pattern in invasive pituitary adenomas: A microarray analysis
Authors: Peng Chao , Wang Shuaikai , Yu Jinxiu , Deng Xiaoyi , Chen Zhishan , Ye Huiyu , Yao Hongru , Cai Hanjia , Li Yanli , Yuan Yong 
Published: January 2022

Abstract
BackgroundsLong non-coding RNAs (lncRNAs) play important roles in tumorigenesis and progression of various cancer types; however, their roles in the development of invasive pituitary adenomas (PAs) remain to be investigated.MethodslncRNA microarray was performed in three invasive and three noninvasive PAs. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed, and coexpression networks between lncRNA and mRNA were constructed. Furthermore, three differentially expressed lncRNAs were selected for validation by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in PA samples. The diagnostic values of these three lncRNAs were further evaluated by receiver operating characteristic (ROC) analysis.ResultsA total of 8872 lncRNAs were identified in invasive and paired noninvasive PAs using lncRNA microarray. Among these, the differentially expressed lncRNAs included 81 that were upregulated and 165 that were downregulated. GO enrichment and KEGG pathway analysis showed that these differentially expressed lncRNAs were associated with post-translational modifications of proteins. Furthermore, we performed target gene prediction and coexpression analysis. The interrelationships between the lncRNAs and mRNAs with significant differential expression were identified. Additionally, three differentially expressed lncRNAs were selected for validation in 41 PA samples by qRT-PCR. The expression levels of FAM182B, LOC105371531, and LOC105375785 in the invasive PAs were significantly (P < 0.05) lower than in the noninvasive PAs, and these results were consistent with the microarray data. ROC analysis suggested that FAM182B and LOC105375785 expression levels could be used to distinguish invasive PAs from noninvasive PAs.ConclusionOur findings demonstrated the lncRNAs expression patterns in invasive PAs. Thus, FAM182B and LOC105375785 may be involved in the invasiveness of PAs and serve as new candidate biomarkers for the diagnosis of invasive PAs.
Harmonising Alzheimer's Disease Cohorts using a Common ETL Tool
Authors: Almeida João Rafael , Pazos Alejandro , Oliveira José Luís 
Published: January 2022

Abstract
Background: Many scientific studies have sought to obtain better understanding of specific medical conditions. Concerning Alzheimer’s Disease, there is a lack of reliable diagnostics and this can be related to the availability of only small-scale ongoing biomarker studies and longitudinal cohorts including these subjects. Aiming to generate more substantial clinical evidence, researchers have started to perform multiple cohort analyses. While this is currently possible by harmonising these cohorts into a common data model, the migration pipelines are usually implemented using programming languages. Therefore, cohort owners may have difficulties in contributing during the validation stage of these pipelines.Results: To reduce the dependency on technical teams’ support when validating the data transformations, we propose the use of an ETL tool with visual features. BIcenter is a collaborative web platform designed to implement ETL tasks through the browser. These pipelines are constructed using drag-and-drop features and intuitive forms to customise the ETL steps. This tool is an open-source project and is accessible at https://bioinformatics-ua.github.io/BIcenter/.Conclusions: Our methodology produces interoperable cohorts for multicentric disease-specific studies. Therefore, we validated this using Alzheimer’s Disease cohorts from several countries, combining at the end 6,669 subjects and 172 medical attributes. The harmonised cohorts now enable multi-cohort querying and analysis, helping in the execution of new studies.
How Carbon Emission Trading Effects Enterprise Technological Innovation: A Quasi-Natural Experiment from China
Authors: Shao Wei , Yang Ke , Chen Ziqi 
Published: January 2022

Abstract
As an important policy tool to realize the vision of "carbon peaking and carbon neutralization", the carbon emission trading system is considered to be useful for alleviating enterprise financing constraints and stimulating high-quality technological innovation. Based on the data of Chinese listed companies, this paper tests the above policy effects by setting a quasi-natural experiment. The conclusions are as follows: (1) The introduction of the market mechanism for carbon emission control can improve the quality of enterprise R & D, and the mitigation of financing constraints has a positive contribution to this improvement; (2) The innovation incentive effect of carbon emission trading system is significant in the sample of state-owned enterprises with government credit endorsement, but it shows the opposite statistical results in non-state-owned enterprises; (3) The incentive effect of carbon emission trading system on innovation quality is higher in heavy pollution industries than others. The above conclusions have important reference value for developing countries to achieve the dual goals of high-quality economic development.