bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large‐Area Inkjet‐Printed OLEDs Patterns and Tiles Using Small Molecule Phosphorescent Dopant
Authors: Kant Chandra , Mahmood Sadiq , Katiyar Monica 
Published: November 2022

AbstractThe main bottleneck in inkjet printing (IJP) is a stable and jettable ink formulation. This paper discusses the ink formulation for the small molecule phosphorescent dopant/host system. The study involves the estimation of Hansen solubility parameters (HSP) to formulate inkjet‐printed ink of an iridium complex‐based phosphorescent material, bis(4‐phenylthieno[3,2‐c]pyridinato‐N,C2') (acetylacetonate) iridium(III) (PO‐01) as dopant and 4, 40‐bis (carbazol‐9‐yl) biphenyl as the host of the emissive layer. Based on dopant and host HSP analyses, toluene and methyl benzoate are chosen as ink solvents. Our ink is stable for a month and can be replicated with great accuracy. The interaction of individual drops is examined in detail since resolution or film quality is highly influenced by the drop formation and spread on a substrate. Finally, an inkjet‐printed emissive layer is demonstrated on both glass and flexible substrates. The fabricated devices exhibit the maximum current efficiency and luminance of 6.4 cd A−1and 5781 cd m−2. A technique is also shown to print large‐area organic light‐emitting diode (OLED) devices having different patterns without patterning or pixelization of the active area of the electrodes. Up to 80 × 80 mm2large‐area OLED tiles are made using IJP of the emissive layer.
Electronic Structure Engineering of Highly‐Scalable Earth‐Abundant Multi‐Synergized Electrocatalyst for Exceptional Overall Water Splitting in Neutral Medium
Authors: Bahuguna Gaurav , Cohen Adam , Filanovsky Boris , Patolsky Fernando 
Published: November 2022

AbstractEfficient neutral water splitting may represent in future a sustainable solution to unconstrained energy requirements, but yet necessitates the development of innovative avenues for achieving the currently unmet required performances. Herein, a novel paradigm based on the combination of electronic structure engineering and surface morphology tuning of earth‐abundant 3D‐hierarchical binder‐free electrocatalysts is demonstrated, via a scalable single‐step thermal transformation of nickel substrates under sulfur environment. A temporal‐evolution of the resulting 3D‐nanostructured substrates is performed for the intentional enhancement of non‐abundant highly‐catalytic Ni3+ and pSn2− species on the catalyst surface, concomitantly accompanied with densification of the hierarchical catalyst morphology. Remarkably, the finely engineered NiSx catalyst synthesized via thermal‐evolution for 24 h (NiSx‐24 h) exhibits an exceptionally low cell voltage of 1.59 V (lower than Pt/C‐IrO2 catalytic couple) for neutral water splitting, which represents the lowest value ever reported. The enhanced performance of NiSx‐24 h is a multi‐synergized consequence of the simultaneous enrichment of oxygen and hydrogen evolution reaction catalyzing species, accompanied by an optimum electrocatalytic surface area and intrinsic high conductivity. Overall, this innovative work opens a route to engineering the active material's electronic structure/morphology, demonstrating novel Ni3+/pSn2−‐enriched NiSx catalysts which surpass state‐of‐the‐art materials for neutral water splitting.
Response of rice growth to soil microorganisms and soil properties in different soil types
Authors: Li Peng , Yan Yue , Li Chao , Tang Wenguang , Xiong Ziqin , Tian Yunhe , Zhou Kun , Yi Zhenxie , Zheng Zhongyi , Rang Zhongwen , Li Juan 
Published: November 2022

AbstractIn order to understand the relationship between rice (Oryza sativa L.) yield and the microbial communities and soil properties of different soil types, and to clarify the advantages of rice production characteristics of different soil types, we investigated the soil bacterial communities and soil properties of five representative rice soils (granitic sandy soil, purple clayey soil, red yellow clayey soil, yellow clayey soil, and alluvial sandy soil) and determined their effects on rice yield. The granitic sandy soil showed the greatest potential for increasing rice yield, with a yield of 39.2 g per plant, which was 24.56% higher than the lowest yielding soil type, these differences were related to differences in the soil microbial community and soil properties. There were significant differences in the microbial communities and chemical properties among the soil types, of which the granitic sandy soil type had the highest total nitrogen, available nitrogen, available kalium, and soil organic carbon contents, which were 2.60 g kg−1, 196.07 mg kg−1, 230.65 mg kg−1, and 24.67 g kg−1, respectively. Moreover, there was a significant correlation among specific bacterial taxa, soil properties, and rice yield, with Bacteroidetes showing a significant positive correlation with rice yield. The results also showed that pH, alkaline soluble nitrogen, and fast‐acting potassium were the key soil properties affecting soil communities and rice yield. Both soil properties and soil microbial community influenced rice yield.
Expanding SPG7 dominant optic atrophy phenotype: Infantile nystagmus and optic atrophy without spastic paraplegia
Authors: Seo Yuri , Lim Hyun Taek , Lee Byung Joo , Han Jinu 
Published: November 2022

AbstractSpastic paraplegia is a neurodegenerative disorder characterized by progressive leg weakness and spasticity due to degeneration of corticospinal axons. SPG7 encodes paraplegin, and pathogenic variants in the gene cause hereditary spastic paraplegia as an autosomal recessive trait. Various ophthalmological findings including optic atrophy, ophthalmoplegia, or nystagmus have been reported in patients with spastic paraplegia type 7. We report a 15‐year‐old male patient with a novel heterozygous variant, c.1224T>G:p.(Asp408Glu) in SPG7 (NM_003119.3) causing early onset isolated optic atrophy and infantile nystagmus prior to the onset of neurological symptoms. Therefore, SPG7 should be considered a cause of infantile nystagmus with optic atrophy.
Ligand‐Assisted Coupling Manipulation for Efficient and Stable FAPbI3 Colloidal Quantum Dot Solar Cells
Authors: Zhang Xuliang , Huang Hehe , Jin Lujie , Wen Chao , Zhao Qian , Zhao Chenyu , Guo Junjun , Cheng Chen , Wang Hongshuai , Zhang Liang , Li Youyong , Maung Maung Yin , Yuan Jianyu , Ma Wanli 
Published: November 2022

AbstractFor emerging perovskite quantum dots (QDs), understanding the surface features and their impact on the materials and devices is becoming increasingly urgent. In this family, hybrid FAPbI3 QDs (FA: formamidium) exhibit higher ambient stability, near‐infrared absorption and sufficient carrier lifetime. However, hybrid QDs suffer from difficulty in modulating surface ligand, which is essential for constructing conductive QD arrays for photovoltaics. Herein, assisted by an ionic liquid formamidine thiocyanate, we report a facile surface reconfiguration methodology to modulate surface and manipulate electronic coupling of FAPbI3 QDs, which is exploited to enhance charge transport for fabricating high‐quality QD arrays and photovoltaic devices. Finally, a record‐high efficiency approaching 15 % is achieved for FAPbI3 QD solar cells, and they retain over 80 % of the initial efficiency after aging in ambient environment (20–30 % humidity, 25 °C) for over 600 h.
Preparation of monodisperse silica powder from acid residue after extracting alumina from coal gangue
Authors: Zhang Tao , Yang Huifen , Zhang Hongbo , Zhang Peng 
Published: November 2022

AbstractA new method for preparing monodisperse silica powder was introduced in this paper. Monodisperse silica powder was synthesized by sol–gel method using sodium silicate prepared from acid residue after alumina extraction from coal gangue leached by NaOH. The dissolution rate of SiO2 was determined according to the potassium fluosilicate volumetric method (GB/T 27974‐2011). The SiO2 dissolution rate reaching 92.74% when dissolution temperature calcined at 90°C for 90 min, the liquid–solid ratio was 8 ml/g, and the concentration of NaOH solution was 30%. The maximum specific surface area of silicon powder reaching 519m2/g when the concentration of sodium silicate was 0.6 mol/l, ethyl acetate concentration was 8%, anhydrous ethanol concentration was 5%, and the reaction time was 90 min. X‐ray fluorescence (XRF), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM) showed that the content of SiO2 in the powder was 99.28%, the particle size was between 30 ~ 300 nm, and more than 90% of the particle size was below 100 nm.
Enhanced mechanical performance of fused filament fabrication copolyester by continuous carbon fiber in‐situ reinforcement
Authors: Zhang Huiying , Zhou Ziyan , Gao Xin , Fan Tianxiang , Chen Ye , Wang Huaping 
Published: November 2022

AbstractAs one of the most commonly used thermoplastics, polyester has rarely been used as the raw materials of 3D printing. However, copolyester obtained by copolymerization modifying polyester, such as Poly Ethylene Terephthalate Glycol (PETG), has been proven to be suitable for the fused filament fabrication (FFF) technique in previous studies, but the mechanical performance of printed products is still poor. In this paper, 3D printed PETG is in‐situ reinforced by continuous carbon fiber (CCF), and the relationship between the process parameters and the mechanical performance of CCF/PETG is systematically investigated. The results show that the performance of 3D printed PETG is significantly enhanced by CCF in‐situ reinforcement due to the effectively impregnation of CCF. By optimizing process parameters, the tensile strength, flexural strength and flexural modulus of CCF/PETG are 597%, 293% and 650% of pure PETG, respectively, with a relatively low fiber mass fraction of 19.2 wt%. This paper demonstrates that CCF in‐situ reinforced 3D printed copolyester may be used in the manufacture of complex structural parts that require high mechanical performance in the engineering application.
Investigating the effect of printing conditions and annealing on the porosity and tensile behavior of 3D‐printed polyetherimide material in Z‐direction
Authors: Ouassil Salah‐Eddine , El Magri Anouar , Vanaei Hamid Reza , Vaudreuil Sébastien 
Published: November 2022

AbstractFused filament fabrication process presents drawbacks in mechanical properties observed when printing in the build direction (Z‐direction). Such anisotropic properties will affect the part's performances and have to be minimized during fabrication. This study aims to evaluate the effects of nozzle temperature, printing speed and specimen state (annealed or as‐printed) on porosity percentage and tensile properties for 3D printed polyetherimide (PEI) (ULTEM 1010) parts in Z‐direction. The results demonstrated that print speed is the most influential process parameter that should be adjusted in consideration with the other printing parameters. The specimens' state did not reveal a noticeable influence, as the amorphous nature of PEI is considered less receptive to annealing. The optimization method to achieve the best results yielded values of 360°C and 30 mm s−1 as printing conditions, followed by heat treatment. This was confirmed by porosity measurements, tensile testing, and scanning electron microscopy observations. The best performances of PEI material were 3425.5 MPa, 102 MPa, and 4.30% for Young's modulus, tensile strength, and elongation at break, respectively.
Teacher‐ and parent‐reported trajectories of maladaptive behaviors among individuals with autism and non‐spectrum delays
Authors: Rosen Nicole E. , Schiltz Hillary K. , Lord Catherine 
Published: November 2022

AbstractPeople with autism spectrum disorder (ASD) and non‐spectrum developmental delays frequently exhibit maladaptive behaviors throughout the lifespan, which can have pervasive effects on quality of life. Maladaptive behaviors have been shown to change over time as a function of various individual‐level factors (e.g., cognitive ability), yet research is primarily limited to parent‐reported measures. To expand upon this work, the present study aimed to examine trajectories of teacher‐ and parent‐reported maladaptive behaviors (i.e., hyperactivity, irritability, social withdrawal) and to test whether individual‐level predictors (e.g., autism features, verbal intelligence quotient) and school‐related predictors (e.g., teacher type, student‐adult ratio, personal aide, school type) impact these trajectories among 165 individuals with ASD or non‐spectrum delays from ages 9 to 18. Multilevel models revealed that, according to both teacher and parent report, participants showed the greatest improvement in hyperactivity, less but still notable improvement in irritability, and stable levels of social withdrawal over time. Higher verbal ability and fewer ASD features, in addition to mainstream school placement, emerged as important individual‐ and school‐related differences associated with fewer maladaptive behaviors over time. The multi‐informant perspective and longitudinal design provide novel insight into the manifestations of these maladaptive behaviors across different contexts and across time. Findings highlight the consistency of teacher‐ and parent‐reported trajectories over time and further emphasize the importance of targeting maladaptive behaviors using a multisystem intervention approach in both school and home contexts.
The prevalence of gene mutations in homologous recombination repair pathways in Japanese patients with metastatic castration‐resistant prostate cancer in real‐world clinical practice: The multi‐institutional observational ZENSHIN study
Authors: Uemura Hiroji , Oya Mototsugu , Kamoto Toshiyuki , Sugimoto Mikio , Shinozaki Kenta , Morita Kiyomi , Koto Ryo , Takahashi Mai , Nii Masahiro , Shin Eisei , Nonomura Norio 
Published: November 2022

AbstractBackgroundMetastatic castration‐resistant prostate cancer (mCRPC) is a genetically heterogeneous disease with a poor prognosis. The prevalence of mutations in homologous recombination repair (HRR) pathway genes, including BRCA1/2, as well as treatment patterns and clinical outcomes, are not well characterized among Japanese men with mCRPC.MethodsThis multicenter, noninterventional cohort study enrolled Japanese men with mCRPC from 24 institutions between 2014 and 2018. Mutations in the 15 HRR‐related genes were assessed using archival primary or metastatic tumor samples. Patterns of sequential therapies for mCRPC were investigated. Patients were followed up for survival evaluation including prostate‐specific antigen progression‐free survival (PSA‐PFS) and overall survival (OS).ResultsOf the 143 patients analyzed, HRR‐related mutations were detected in 51 patients (35.7%). The most frequently mutated genes were CDK12 (N = 19, 13.3%), followed by BRCA2 (N = 18, 12.6%), ATM (N = 8, 5.6%), and CHEK2 (N = 3, 2.1%). The most common type of first‐line therapy for mCRPC was next‐generation hormonal agents (NHA, 44.4%), followed by first‐generation antiandrogens (FGA, 30.3%), and taxanes (22.5%). Commonly prescribed first−/second‐line sequential regimens included FGA/NHA (17.6%), NHA/NHA (15.5%), and NHA/taxanes (14.1%). The median PSA‐PFS and OS for the entire cohort were 5.6 and 26.1 months, respectively. Patients carrying BRCA1/2 mutations had numerically shorter PSA‐PFS (median 3.3 vs. 5.9 months) and OS (median 20.7 vs. 27.3 months) than those without mutations.ConclusionsIn conclusion, approximately one‐third of Japanese patients with mCRPC carried mutations in HRR‐related genes in this study. The real‐world outcomes of mCRPC are poor with conventional therapy, warranting an expansion of treatment options based on genetic abnormalities of the disease.
Trends in survival for cancer patients aged 65 years or over from 1995 to 2014 in the United States: A population‐based study
Authors: An Lan , Ju Wen , Zheng Rongshou , Zeng Hongmei , Zhang Siwei , Chen Ru , Sun Kexin , Li Li , Wang Shaoming , Wei Wenqiang 
Published: November 2022

AbstractBackgroundAdults aged 65 years and above account for over half of all cancer diagnoses in the United States, but little is known about trend of elderly cancer survival in the United States. We aimed to assess the survival trend for elderly cancer in the United States from 1995 to 2014.MethodsWe used data from Surveillance, Epidemiology, and End Results 12 registries and included 1,112,441 eligible patients aged 65 years or older who were diagnosed between 1995 and 2014 with cancer and followed up until December 2019. Overall and stage‐specific 5‐year relative survival, ratio of observed survival to expected survival, with 95% confidence intervals (CIs) of elderly cancer patients stratified by age were estimated during four periods (1995–1999, 2000–2004, 2005–2009, and 2010–2014). Cox proportional hazards models were used to estimate hazard ratios for cancer‐specific death among patients diagnosed during 2000–2004, 2005–2009, 2010–2014, compared diagnoses in 1995–1999. We also calculated stage distribution and treatment rate during four periods.ResultsIn the United States, 5‐year relative survival for elderly cancer patients improved from 57.3% (95% CIs 57.0–57.5) in 1995–1999 to 60.7% (60.5–60.9) in 2010–2014. After controlling for sociodemographic and tumor characteristics, about a 19% reduction in cancer‐specific deaths among diagnoses in 2010–2014 compared with 1995–1999. Cancer survival improved for elderly patients in all age groups, with exception of stable survival for patients aged 85 and above. Comparing 1995–1999 with 2010–2014, relative survival improved from 84.7% (84.3–85.1) to 86.7% (86.3–87.0) for localized stage and from 12.4% (12.1–12.7) to 18.7% (18.4–19.0) for distant stage for all cancers combined. The trends in stage distribution and treatment rate for all cancers combined were relatively stable.ConclusionsIn the United States, survival for elderly cancer patients has improved slightly from 1995 to 2014, possibly mainly due to advances in treatment. Further studies are warranted to explore interventions to improve elderly cancer survival.
Synthesis, characterization and absolute configurations of methyl ladderanoates
Authors: Harris Constance M. , Harris Thomas M. , Stec Donald F. , Schley Nathan D. , Johnson Jordan L. , Covington Cody L. , Polavarapu Prasad L. 
Published: November 2022

AbstractMethyl esters of [5]‐ladderanoic acid and [3]‐ladderanoic acid were prepared by esterification of the acids isolated from biomass at a wastewater treatment plant. Optical rotations at six different wavelengths (633, 589, 546, 436, 405 and 365 nm) and vibrational circular dichroism (VCD) spectra in the 1800–900 cm−1 region were measured in CDCl3 solvent and compared with quantum chemical (QC) predictions using B3LYP functional and 6‐311++G(2d,2p) basis set with polarizing continuum model representing the solvent. QC predictions gave negative optical rotations at all six wavelengths for (R)‐methyl [5]‐ladderanoate and positive optical rotations for (R)‐methyl [3]‐ladderanoate, the same signs as previously reported for the corresponding acids. The crystal structure of (−)‐methyl [5]‐ladderanoate independently confirmed (R) configuration. The QC‐predicted VCD spectra using Boltzmann population weighted spectra of individual conformers did not provide satisfactory quantitative agreement with the experimental VCD spectra. An improved quantitative agreement for VCD spectra could be obtained when conformer populations were optimized to maximize the similarity between experimental and predicted VCD spectra, but more improvements in VCD predictions are needed.
Sky‐Blue Aggregation‐Induced Delayed Fluorescence Luminogens with High Horizontal Dipole Orientation for Efficient Organic Light‐Emitting Diodes†
Authors: Huang Ruishan , Yang Zuguo , Chen Hao , Liu Hao , Tang Ben Zhong , Zhao Zujin 
Published: November 2022

Comprehensive SummaryEfficient and stable blue luminescent organic materials are highly demanded in the field of organic light‐emitting diodes (OLEDs) but still remain challenging. In this work, two new sky‐blue luminescent molecules comprised of electron acceptor of benzophenone and electron donors of spiro[acridine‐9,9'‐fluorene] and carbazole are designed and synthesized, and their thermal stability, electrochemical behaviors, photophysical properties, carrier transport ability and electroluminescence performance are investigated. They exhibit distinct merits of aggregation‐induced delayed fluorescence with high solid‐state photoluminescence quantum yields, balanced bipolar carrier transport and high horizontal dipole ratios. Highly efficient OLEDs using both molecules as emitters are obtained, which radiate strong sky‐blue light and provide outstanding external quantum efficiencies of up to 33.3% with small roll‐offs.
Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides
Authors: Ahmadi Mohammad , Ahmadyousefi Yaghoub , Salimi Zahra , Mirzaei Rasoul , Najafi Rezvan , Amirheidari Bagher , Rahbarizadeh Fatemeh , Kheshti Javad , Safari Armin , Soleimani Meysam 
Published: November 2022

AbstractActive targeting using biological ligands has emerged as a novel strategy for the targeted delivery of diagnostic agents to tumor cells. Conjugating functional targeting moieties with diagnostic probes can increase their accumulation in tumor cells and tissues, enhancing signal detection and, thus, the sensitivity of diagnosis. Due to their small size, ease of chemical synthesis and site‐specific modification, high tissue penetration, low immunogenicity, rapid blood clearance, low cost, and biosafety, peptides offer several advantages over antibodies and proteins in diagnostic applications. Epidermal growth factor receptor (EGFR) is one of the most promising cancer biomarkers for actively targeting diagnostic and therapeutic agents to tumor cells due to its active involvement and overexpression in various cancers. Several peptides for EGFR‐targeting have been identified in the last decades, which have been obtained by multiple means including derivation from natural proteins, phage display screening, positional scanning synthetic combinatorial library, andin silicoscreening. Many studies have used these peptides as a targeting moiety for diagnosing different cancersin vitro, in vivo, and in clinical trials. This review summarizes the progress of EGFR‐targeting peptide‐based assays in the molecular diagnosis of cancer.
Heat‐Shock Proteins
Authors: Hagymasi Adam T. , Dempsey Joseph P. , Srivastava Pramod K. 
Published: November 2022

AbstractHeat‐shock proteins (HSPs), or stress proteins, are abundant and highly conserved, present in all organisms and in all cells. Selected HSPs, also known as chaperones, play crucial roles in folding and unfolding of proteins, assembly of multiprotein complexes, transport and sorting of proteins into correct subcellular compartments, cell‐cycle control and signaling, and protection of cells against stress and apoptosis. More recently, HSPs have been shown to be key players in immune responses: during antigen presentation as well as cross‐priming, they chaperone and transfer antigenic peptides to class I and class II molecules of the major histocompatibility complexes. In addition, extracellular HSPs can stimulate and cause maturation of professional antigen‐presenting cells of the immune system, such as macrophages and dendritic cells. They also chaperone several toll‐like receptors, which play a central role in innate immune responses. HSPs constitute a large family of proteins that are often classified based on their molecular weight as Hsp10, Hsp40, Hsp60, Hsp70, Hsp90, etc. This unit contains a table that lists common HSPs and summarizes their characteristics including (a) name, (b) subcellular localization, (c) known function, (d) chromosome assignment, (e) brief comments, and (f) references. © 2022 Wiley Periodicals LLC.