bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pricing exotic options in the incomplete market: An imprecise probability method
Authors: He Ting , Coolen Frank P. A. , Coolen‐Maturi Tahani 
Published: January 2022

AbstractThis article considers a novel exotic option pricing method for incomplete markets. Nonparametric predictive inference (NPI) is applied to the option pricing procedure based on the binomial tree model allowing the method to evaluate exotic options with limited information and few assumptions. As the implementation of the NPI method is greatly simplified by the monotonicity of the option payoff in the tree, we categorize exotic options by their payoff monotonicity and study a typical type of exotic option in each category, the barrier option and the look‐back option. By comparison with the classic binomial tree model, we investigate the performance of our method either with different moneyness or varying maturity. All outcomes show that our model offers a feasible approach to price the exotic options with limited information, which makes it can be utilized for both complete and incomplete markets.
Kinetic characterization and modeling of sequentially entrapped enzymes in 3D‐printed PMMA microfluidic reactors for the synthesis of amorphadiene via the isopentenol utilization pathway
Authors: Kabernick Derek C. , Gostick Jeff T. , Ward Valerie C. A. 
Published: January 2022

AbstractThe development of cascade cell‐free systems reduces the requirement for extensive metabolic engineering and optimization to increase in vivo pathway flux. For continuous operation and increased stability, direct enzyme entrapment during reactor fabrication by three‐dimensional (3D)‐printing allows for simple immobilization procedures without enzyme‐specific optimization. In this study, the isopentenol utilization pathway (IUP) was selected for the synthesis of amorphadiene, an antimalaria drug precursor, using a 3D‐printed, sequentially immobilized, microfluidic reactor. As an initial proof‐of‐concept, alkaline phosphatase (ALP) was entrapped in a poly(methyl methacrylate) (PMMA)‐based matrix during stereolithographic 3D‐printing and was kinetically characterized. No significant shift of the kinetically modeled substrate binding affinity was observed during immobilization and continuous operation of an entrapped ALP microfluidic reactor displayed high stability. The IUP enzymes retained moderate activity during entrapment (6.6%–9.6%) relative to the free enzyme solutions, however the sequentially immobilized IUP microfluidic reactor was severely limited by low pathway flux due to the use of stereolithographic 3D‐printing which significantly diluted enzyme concentrations for printing. Although this study demonstrated the use of additive manufacturing for the synthesis of amorphadiene using a complex five‐enzyme cascade microfluidic reactor, stereolithographic enzyme entrapment remains limited in scope and dependent on advancements to additive manufacturing technologies.
Acetonitrile coordination to silver(I) ions of 1‐D coordination polymers with 1,3‐di(nicotinoyloxy)‐2‐methylenepropane
Authors: Jo Seong Min , Noh Tae Hwan 
Published: January 2022

AbstractThe fluorescent molecule 1,3‐di(nicotinoyloxy)‐2‐methylenepropane (L) can be a good candidate for construction of coordination polymers with photoluminescence (PL) properties. Self‐assembly of silver(I) hexafluorophosphate with this ligand in a mixture of methanol and dichloromethane produced a 1‐D helical coordination polymer consisting of [Ag(L)](PF6), whereas crystallization from an acetonitrile‐based medium afforded a 1‐D sinusoidal coordination polymer consisting of [Ag(L)(CH3CN)2](PF6) having intramolecular argentophilic Ag∙∙∙Ag and π∙∙∙π interactions arising from the eclipsed conformation of L. These findings suggest that the final structures of the two products can be controlled by the reaction solvent media rather than the crystallization method or concentration. The physicochemical properties of the present silver(I) compounds were fully characterized by means of infrared spectroscopy, thermogravimetric analysis/differential scanning calorimetry, PL, single‐crystal x‐ray diffraction (XRD), and powder‐XRD measurements.
Effect of online social media marketing efforts on customer response
Authors: Upadhyay Yogesh , Paul Justin , Baber Ruturaj 
Published: January 2022

AbstractIt has been a challenge to map the efficacy of marketing communications in building stronger brands on social media. Given the paucity of research in this area, the present study offers a holistic model that maps the effect of social media marketing (hereinafter SMMEs) on consumer response via building brand equity and brand trust. This study was conducted on customers of major brands of smartphones in India. The data were collected from 318 consumers who visited fan pages of the selected brands of smartphones. The current study examines how SMMEs influence customer behavior via brand equity and trust. Additionally, the study examines how brand equity and brand trust interact during the process. The current study's findings indicate that brand equity partially mediates the effect of SMMEs on customer response. On the other hand, SMMEs do not succeed in converting brand trust into customer response. Further, brand equity fully mediates SMMEs' effect on brand trust. Finally, the results also show that the effect of brand equity on customer response is partially mediated by brand trust. Toward the end, study dwells on its practical implications and limitations.
Effect of different mills on the physical and flow properties of selected black bean flour particle size fractions
Authors: Fernando Supun , Manthey Frank A. 
Published: January 2022

AbstractBackground and ObjectivesParticle size and shape can influence inherent flour properties and eventually the quality of the finished food product. The objective of this study was to determine the effect of mill type on the physical and flow properties of selected particle size fractions of black bean flour.FindingsParticle shape differed with mill type and particle size. Disc mill and stone mill produced flour particles with lower circularity and greater elongation than did hammer mill, cyclone mill, and centrifugal mill. Greater particle elongation with a stone mill and disc mill is attributed to compression/shear size‐reduction forces applied to the particles trapped between the rotating/nonrotating stones or discs. Particle circularity increased with an increased particle size, which was reflected by a strong positive correlation between circularity and particle size (r = .93, n = 5) while elongation value was negatively correlated with average minimum particle size (r = −.90, n = 5). Particle circularity had a negative correlation of r = −.93, n = 30; r = −.81, n = 30; r ≈ −.95, n = 30; r = −.94, n = 30 with L*, angle of repose, angle of slide, and compact bulk density, respectively.ConclusionsMill type and particle size interaction significantly affected the physical and flow properties of selected particle size fractions of black bean flour. The results indicate that the large black bean particles were more circular and compact and less convex and elongated compared with small particles.Significance and NoveltyThese findings indicate that mill type affects not only particle size but also particle shape, both of which can affect the flow and functional processing properties of black bean flour.
3D‐Printed Acidic Monolithic Catalysts for Liquid‐Phase Catalysis with Enhanced Mass Transfer Properties
Authors: Hock Sebastian , Rein Christof , Rose Marcus 
Published: January 2022

AbstractThe thriving research and development in additive manufacturing and especially 3D printing in chemical engineering and heterogeneous catalysis enables novel and innovative approaches for the shaping of catalysts. In this work, tailor‐made monoliths with complex transport pore channels are designed and printed by fused deposition modelling (FDM) from polystyrene filament. Subsequently, sulfonic acid groups are introduced by sulfonation for a catalytic functionalization of the structured monoliths’ accessible inner surface. As a catalytic test reaction, the aqueous phase hydrolysis of sucrose was chosen. For this reaction the functionalized monoliths exhibited a superior catalytic performance in both batch and continuous reaction mode in comparison to a macroporous sulfonic acid‐functionalized ion exchange resin as commercial benchmark catalyst. This is due to the higher accessibility of the sulfonic acid groups on the surface of the monoliths’ pore channels and hence, enhanced effective reaction kinetics by decreased mass transfer limitations.
Konzepte zur Integration erneuerbarer synthetischer Kraftstoffe in einen bestehenden Raffinerieverbund
Authors: Graf David , Koroveshi Xhesika , Kolb Thomas , Rauch Reinhard 
Published: January 2022

AbstractDie Bewältigung der globalen Klimakrise fordert neben neuen Ansätzen auch Strategien zur Transformation fossiler Technologien im Sinne der Nachhaltigkeit. Im Verkehrssektor ist der zukünftige nicht‐fossile Energiemix weiterhin nur schwer absehbar. Neben der sicheren Elektrifizierung des Nahverkehrs ist es unumgänglich für die Übergangsphase sowie auch für den Transportsektor Alternativen aufzuzeigen. In der vorliegenden Studie wird die Integration erneuerbarer Benzin‐ und Dieselkraftstoffe nach der Biomass‐to‐Liquid‐ und Power‐to‐Liquid‐Route in eine Raffinerie diskutiert und basierend auf Bilanzen bewertet.
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity
Authors: Schulte Bianca , König Maria , Escher Beate I. , Wittenburg Sophie , Proj Matic , Wolf Valentina , Lemke Carina , Schnakenburg Gregor , Sosič Izidor , Streeck Hendrik , Müller Christa E. , Gütschow Michael , Steinebach Christian 
Published: January 2022

AbstractNaturally occurring compounds represent a vast pool of pharmacologically active entities. One of such compounds is andrographolide, which is endowed with many beneficial properties, including the activity against severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2). To initiate a drug repurposing or hit optimization campaign, it is imperative to unravel the primary mechanism(s) of the antiviral action of andrographolide. Here, we showed by means of a reporter gene assay that andrographolide exerts its anti‐SARS‐CoV‐2 effects by inhibiting the interaction between Kelch‐like ECH‐associated protein 1 (KEAP1) and nuclear factor erythroid 2‐related factor 2 (NRF2) causing NRF2 upregulation. Moreover, we demonstrated that subtle structural modifications of andrographolide could lead to derivatives with stronger on‐target activities and improved physicochemical properties. Our results indicate that further optimization of this structural class is warranted to develop novel COVID‐19 therapies.
Matched cohort study of hospitalization in children who have siblings with cancer
Authors: Auger Nathalie , Marcoux Sophie , Bégin Philippe , Lewin Antoine , Lee Ga Eun , Healy‐Profitós Jessica , Luu Thuy Mai 
Published: January 2022

BackgroundHealth outcomes of children in families affected by cancer are poorly understood. The authors assessed the risk of hospitalization in children who have a sibling with cancer.MethodsThis was a longitudinal cohort study in which 1600 children who had a sibling with cancer were matched to 32,000 children who had unaffected siblings in Quebec, Canada, from 2006 to 2020. The exposure of interest was having a sibling with cancer. Outcomes included hospitalization for pneumonia, asthma, fracture, and other morbidities any time after the sibling was diagnosed with cancer. The children were followed over time, and Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the impact of having a sibling with cancer on the risk of hospitalization before age 14 years, adjusted for patient characteristics.ResultsChildren who had a sibling with cancer had an increased risk of hospitalization compared with unaffected children (HR, 1.15; 95% CI, 1.02‐1.29). Conditions associated with a greater risk of hospitalization included pneumonia, hemangioma, other skin conditions, sleep apnea, and inflammatory bowel disease. The risk of hospitalization was greatest for children whose older sibling had cancer (HR, 1.16; 95% CI, 1.01‐1.32) and for children whose sibling had hematopoietic cancer (HR, 1.22; 95% CI, 1.01‐1.48).ConclusionsChildren who have a sibling with cancer are at risk of hospitalization for conditions such as pneumonia, inflammatory bowel disease, and other morbidities. Families affected by childhood cancer may benefit from additional support to facilitate care for all children in the family.Lay Summary

Little is known about the health of children who have a brother or sister with cancer.

The authors studied the types of hospitalization experienced by children who have siblings with cancer.

The results indicated that having a sibling with cancer increased the chance of being hospitalized for pneumonia and other conditions that could have been preventable.

The results also indicated that children who had an older sibling with cancer or a sibling with blood cancer had a greater chance of being hospitalized.

The findings highlight the importance of providing timely care for children in families affected by childhood cancer.
A Bayesian approach to blood rheological uncertainties in aortic hemodynamics
Authors: Ranftl Sascha , Müller Thomas Stephan , Windberger Ursula , Brenn Günter , von der Linden Wolfgang 
Published: January 2022

AbstractComputational hemodynamics has received increasing attention recently. Patient‐specific simulations require questionable model assumptions, for example, for geometry, boundary conditions, and material parameters. Consequently, the credibility of these simulations is much doubted, and rightly so. Yet, the matter may be addressed by a rigorous uncertainty quantification. In this contribution, we investigated the impact of blood rheological models on wall shear stress uncertainties in aortic hemodynamics obtained in numerical simulations. Based on shear‐rheometric experiments, we compare the non‐Newtonian Carreau model to a simple Newtonian model and a Reynolds number‐equivalent Newtonian model. Bayesian Probability Theory treats uncertainties consistently and allows to include elusive assumptions such as the comparability of flow regimes. We overcome the prohibitively high computational cost for the simulation with a surrogate model, and account for the uncertainties of the surrogate model itself, too. We have two main findings: (1) The Newtonian models mostly underestimate the uncertainties as compared to the non‐Newtonian model. (2) The wall shear stresses of specific persons cannot be distinguished due to largely overlapping uncertainty bands, implying that a more precise determination of person‐specific blood rheological properties is necessary for person‐specific simulations. While we refrain from a general recommendation for one rheological model, we have quantified the error of the uncertainty quantification associated with these modeling choices.
Surfactant‐Free and Microporous AlOOH/Al2O3 Nanosheets on TiO2‐Based Nanofibers: A Sustained‐Release Dominated Topotactic Transformation
Authors: Fu Wanlin , Zhan Qi , Yu Ying , Meng Xiangyu , Tang Mingyu , Wang Yunpeng , Sun Yueming , Dai Yunqian 
Published: January 2022

AbstractUp to now, the synthesis of non‐ligand‐capped 2D transition‐metal nanostructures remained big synthetic challenges. Herein, ultrathin and microporous AlOOH/Al2O3 nanosheets were topologically grown on the surface of TiO2‐based nanofibers by a water‐only hydrothermal strategy starting from electrospun Al2O3/TiO2 nanofibers. The TiO2 nanofibers lowered the surface energy for the sustained‐released aluminum species and thereby allowed them in situ hydrated to laminar AlOOH. The metastable AlOOH tended to dehydrate to Al2O3 simultaneously, leaving a well‐maintained 2D structure with sharp corners and steps, as well as enriched micropores. The nanosheets‐on‐nanofibers exhibited 2856–3370 mg/g of adsorption capacity toward RhB and an efficient removal efficiency over 70% at high throughput (30 mL/h). The promoted light‐harvesting by the perpendicularly attached nanosheets further endowed a significant photodegradation for RhB within 1 h. The presented green and facile approach toward the fabrication of 2D metal oxide nanostructures paves the way to a new variety of oxide nanomaterials.
Temperature‐Dependent Terahertz Spectra of Isonicotinamide in the Form I Studied Using the Quasi‐Harmonic Approximation
Authors: Li Yin , Sun Yiwen , Li Qiqi , Lei Jiangtao , Yang Bo , Shen Yun , Cai Yingxiang , Deng Xiaohua 
Published: January 2022

AbstractAnharmonicity of molecular vibrational motions is closely associated with the thermal property of crystals. However, the origin of anharmonicity is still not fully understood. Low‐frequency vibrations, which are usually defined in the terahertz (THz) range, show excellent sensitivity to anharmonicity. In this work, anharmonicity of isonicotinamide in the form I was investigated by using temperature‐dependent terahertz time‐domain spectroscopy and the quasi‐harmonic approximation (QHA) approach at PBE‐D3 and PBE‐MBD levels. Both DFT calculations suggest the variation of π‐π stacking conformation dominates in the thermal expansion of the unit cell. Frequency shifts of the modes in THz range obtained by QHA approach are found to be qualitatively consistent with experimental observations, demonstrating QHA approach is a useful tool for the interpretation of frequency shifts of modes induced by temperature.
Synergistic Effects of Surface Coating and Bulk Doping in Ni‐Rich Lithium Nickel Cobalt Manganese Oxide Cathode Materials for High‐Energy Lithium‐Ion Batteries
Authors: Reissig Friederike , Lange Martin A. , Haneke Lukas , Placke Tobias , Zeier Wolfgang G. , Winter Martin , Schmuch Richard , Gomez‐Martin Aurora 
Published: January 2022

AbstractInvited for this month′s cover is a combined work of the Helmholtz Institute Münster together with the MEET Battery Research Center and the Universities of Münster and Mainz. The cover shows multiple treatment choices for the modification of cathode active materials for lithium‐ion batteries. Similar to a car wash program, the treatment will typically result in an improvement of the status quo. However, the best treatment procedure will only become clear if all modification pathways are explored. The Research Article itself is available at 10.1002/cssc.202102220.
Trends and characteristics of hospitalizations for heart failure in the United States from 2004 to 2018
Authors: Salah Husam M. , Minhas Abdul Mannan Khan , Khan Muhammad Shahzeb , Khan Safi U. , Ambrosy Andrew P. , Blumer Vanessa , Vaduganathan Muthiah , Greene Stephen J. , Pandey Ambarish , Fudim Marat 
Published: January 2022

AbstractAimsHospitalization for heart failure (HF) constitutes a major healthcare and economic burden. Trends and characteristics of hospitalizations for HF for the recent years are not clear. We sought to determine the trends and characteristics of hospitalization for HF in the United States.Method and resultsA retrospective analysis of the National Inpatient Sample weighted data between 1 January 2004 and 31 December 2018, which included hospitalized adults ≥ 18 years with primary discharge diagnosis of HF using International Classification of Diseases‐9/10 administrative codes. Main outcomes were trends in hospitalizations for HF (per 1000 person) and inpatient mortality (%) between 2004 and 2018.ConclusionsHospitalizations for HF have been increasing across both sexes and age groups since 2013, whereas inpatient mortality has been decreasing over the study period. Blacks have the highest risk of hospitalization for HF, and Whites have the highest in‐hospital mortality. There are significant racial and geographic disparities related to hospitalizations for HF.
Decoding the signaling profile of hematopoietic progenitor kinase 1 (HPK1) in innate immunity: A proteomic approach
Authors: Bader Almke , Winkelmann Michael , Forné Ignasi , Walzog Barbara , Maier‐Begandt Daniela 
Published: January 2022

AbstractSignaling via β2 integrins (CD11/CD18) as well as TCRs and BCRs involves similar pathways. However, the activation of the same signaling molecule can result in opposing effects. One such example is the hematopoietic progenitor kinase 1 (HPK1), which negatively regulates T and B cell activation but enforces neutrophil adhesion via β2 integrins. This difference may be defined by specific HPK1 interacting networks in different leukocyte subsets which have already been described in the adaptive immune system. Here, we set out to identify interacting proteins of HPK1 in neutrophil‐like differentiated HL‐60 cells exposed to immobilized fibrinogen and left nonactivated or Mn2+‐activated to allow β2 integrin‐dependent adhesion. Co‐IP experiments followed by mass spectrometry led to the identification of 115 HPK1‐interacting proteins. A total of 58 proteins were found only in nonactivated cells and 39 proteins only in Mn2+‐activated adherent cells. From these results, we decoded a pre‐existing signaling cluster of HPK1 in nonactivated cells encompassing proteins essential for β2 integrin‐mediated signaling during neutrophil trafficking, namely DNAX‐activation protein 12 (DAP12), spleen tyrosine kinase (Syk), and Rac1. Thus, our study provides novel insights into the complex architecture of the signaling processes during neutrophil activation and the complex signaling profile of HPK1 in leukocytes.
Controlled‐release nitrogen fertilizer management influences grain yield in winter wheat by regulating flag leaf senescence post‐anthesis and grain filling
Authors: Ma Quan , Sun Quan , Zhang Xinbo , Li Fujian , Ding Yonggang , Tao Rongrong , Zhu Min , Ding Jinfeng , Li Chunyan , Guo Wenshan , Zhu Xinkai 
Published: January 2022

AbstractControlled‐release nitrogen fertilizer (CRNF) is expected to meet the nutrient demands for crop growth with single fertilizer application, so as to achieve high‐yield, high‐efficiency, and labor‐saving cultivation. However, under current CRNF practices, a single application of CRNF in winter wheat (Triticum aestivum L.) usually fails to achieve satisfactory effects due to insufficient nitrogen (N) supply in the later growth stage, contributing to premature leaf senescence and poor grain filling. To determine a reasonable CRNF application strategy for improving the grain weight and yield of winter wheat, the responses of leaf senescence, photosynthetic capacity, grain‐filling characteristics, and grain yield to different CRNF types [polymer‐coated urea (PCU), sulfur‐coated urea (SCU), and urea‐formaldehyde (UF)] and fertilization practices [single fertilization (P1) and twice‐split fertilization (P2)] were investigated. The results showed that, compared with P1, P2 increased the activities of catalase, peroxidase, and superoxide dismutase, alleviated the accumulation of malondialdehyde, delayed flag leaf senescence, and enhanced the net photosynthetic rate (Pn) of the flag leaves, which promoted assimilate accumulation and transport to the grains. These advantages in P2 improved the grain‐filling process of wheat, with the active filling duration (T), average filling rate (G), and maximum filling rate (Gmax) in P2 all being higher than those in P1, which significantly increased the 1000‐grain weight (TGW) and grain yield of wheat. Among the three CRNFs, PCU showed advantages in Pn at the milk‐ripe stage (Zadoks growth stage, GS75), dry matter accumulation post‐anthesis, T, Gmax, and G, which contributed to TGW and grain yield. Overall, our study suggested that the twice‐split application of CRNF could substantially delay leaf senescence post‐anthesis and increase photosynthetic capacity, thus improving grain filling and productivity in winter wheat.