bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing Deep Learning Models for the Classification of Pediatric Elbow Radiographic Abnormalities of Comparable Performance to Physicians: Strategies for Model Optimization With Small Sized Development Sets
Authors: TAN Mark B. , CHUA Russ Y. , FAN Qiao , FORTIER Marielle V. , CHANG Pearlly P. 
Published: January 2022

Abstract
BackgroundTo compare the performance of an AI model based on strategies designed to overcome small sized development sets to pediatric ER physicians at a classification triage task of pediatric elbow radiographs. Methods1,314 pediatric elbow lateral radiographs (mean age: 8.2 years) were retrospectively retrieved, binomially classified based on their annotation as normal or abnormal (with pathology), and randomly partitioned into a development set (993 images), tuning set (109 images), second tuning set (100 images) and test set (112 images). The AI model was trained on the development set and utilized the EfficientNet B1 compound scaling network architecture and online augmentations. Its performance on the test set was compared to a group of five physicians (inter-rater agreement: fair). Statistical analysis: AUC of AI model - DeLong method. Performance of AI model and physician groups - McNemar test. ResultsAccuracy of the model on the test set - 0.804 (95% CI, 0.718 - 0.873), AUROC - 0.872 (95% CI, 0.831 - 0.947). AI model performance compared to the physician group on the test set - sensitivity 0.790 (95% CI 0.684 to 0.895) vs 0.649 (95% CI 0.525 to 0.773), p value 0.088; specificity 0.818 (95% CI 0.716 to 0.920) vs 0.873 (95% CI 0.785 to 0.961), p value 0.439.ConclusionsThe AI model for elbow radiograph triage designed with strategies to optimize performance for a small sized development set showed comparable performance to physicians.
Lumboperitoneal Shunt Surgery Under Rachianesthesia
Authors: Goto Yukihiro , Nozuchi Shinji , Inoue Takuro 
Published: January 2022

Abstract
Purpose: In the very elderly, complications such as postoperative pneumonia or delirium, which are directly associated with longer hospitalization, are more frequent. In order to overcome these drawbacks, we switched from general anesthesia to rachianesthesia for the lumboperitoneal shunt (LPS) procedure in idiopathic normal pressure hydrocephalus (iNPH) patients. This is because iNPH suffers particularly elderly patients, and neuraxial anesthesia techniques such as rachianesthesia reportedly decrease postoperative complications in patients of very advanced age as compared with general anesthesia. Methods: We retrospectively analyzed 45 patients who underwent LPS in our institution, and divided them into two groups based on the anesthetic approach; 1) general anesthesia, 2) rachianesthesia. We analyzed these two groups with regard to postoperative delirium score and the hospital stay.Results: In the general anesthesia group, two patients had respiratory complications after the surgery. The mean postoperative delirium score using the intensive care delirium screening checklist (ICDSC) was 1.3 (1.4) and the length of hospital stay was 13.9 (4.7) days. In the rachianesthesia group, no patients had respiratory complications. The postoperative mean ICDSC was 1.3 (1.4), and the length of hospital stay was 10.8 (2.1) days. The statistical analysis showed the rachianesthesia group to have significantly shorter hospital stays.Conclusions: LPS under rachianesthesia is an alternative to performing this procedure under general anesthesia in elderly patients.
Global Growth in Offshore Wind Turbine Technology
Authors: Bilgili Mehmet , Alphan Hakan 
Published: January 2022

Abstract
Due to the commissioning of floating wind units, the latest technological developments, significant growth, and improvements in turbines, developments in offshore wind power capacity are estimated to increase faster than in the last two decades. The total installed offshore wind power capacity, which is currently 35 GW, is predicted to be approximately 382 GW by 2030 and approximately 2,002 GW by 2050. For this reason, attempts are proposed to lower levelised cost of electricity (LCOE) for offshore wind power generation more than for other energy sources. In this study firstly, the global growth in the nominal capacity and size of offshore wind turbines over the last twenty years is examined. Then, the effects of this increase in nominal capacity and size on the LOCE, total installation cost (TIC), and turbine capacity factor are investigated. In parallel with this development, the changes in distance to shore and water depth for installation offshore wind power plants are reviewed according to the years. In addition, the effects of this global growth on wind farm capacity, turbine-specific power capacity, number of turbines per GW, and area needed per GW are investigated and discussed in detail.
A web-based survey on factors for unvaccination and adverse reactions of SARS-CoV-2 vaccines in Chinese postoperative patients with breast cancer
Authors: Liao Liqiu 
Published: January 2022

Abstract
Background
Vaccination against SARS-COV-2 has been the most important strategy for preventing infection of Coronavirus disease 2019 (COVID-19). Breast cancer is the most common malignancy in women, but there is a lack of research on the pandemics in postoperative patients with breast cancer.
Objective
To investigate the rate and factors for SARS-CoV-2 vaccination and adverse reactions after vaccination in postoperative patients with breast cancer.
Methods
A web-based questionnaire survey on SARS-CoV-2 vaccination in postoperative patients with breast cancer among women.
Results
A total of 947 online questionnaires were collected. Of these, 341 accepted SARS-CoV-2 vaccination, while 606 were not vaccinated. There were significant differences in age, current treatment, the time since surgery, and the symptoms of anxiety and depression between the two groups. We identified current treatment (OR=0.51 for endocrine therapy; 95% CI: 0.29-0.89), the time since surgery (OR=22.49 for 1-2 years; 95% CI: 12.31-41.10; OR=8.49 for 2-5 years ; 95% CI: 4.98-14.46; OR=1.79 for >5 years ; 95% CI: 1.11-2.89), and the symptoms of depression (OR=2.48; 95% CI: 1.19-5.15) as significant factors for unvaccination. The overall incidence of adverse reactions was 43.1%. The most common local and systemic adverse reactions were pain at the injection site (28.4%) and fatigue (8.8%), respectively.
Conclusion
Postoperative patients with breast cancer have a relatively lower rate of vaccination for SARS-CoV-2 than the general population. Receiving treatment, a shorter time since surgery and symptom of depression were associated with unvaccination. More importantly, a favorable safety profile of the vaccines is indicated.
Mental Health Consequences from COVID-19 Pandemic and Strategies for Community Level Recovery
Authors: Somasundaram Daya , Rajeshkannan Nadarajah , Kumarendran Balachandran , Kumanan Thirunavukarasu , Sugirthan Nalayini , Aloysius Ivan Dinesh , Sasikumar Sivanandan , Jegathesan Nalayini 
Published: January 2022

Abstract

Background: The COVID-19 pandemic has spread across the globe from 2019 affecting millions of people physically, mentally, and socio-economically. The purpose of the study was to map out the mental health consequences of the COVID-19 Pandemic and suggest recovery strategies.Methods: A qualitative inquiry into the mental health aspects of the COVID-19 pandemic using observations from working in busy health clinics, general practices, primary and community care setting, and dedicated COVID acute care wards during the pandemic in Australia, United Kingdom and Sri Lanka; discussions with colleagues worldwide; analyzing social and news media comments; literature survey and experience of dealing with past disasters were used to map out mental health consequences and put forward recovery strategies.Results: In covid sufferers, neuropsychiatric symptoms lasting months, unrelated to respiratory insufficiency suggested brain damage due to vascular endothelial injury and/or cerebral venous thrombosis (CVT). A third went onto develop or have a relapse of a psychological or neurological conditions. In the general population, common consequences included common mental health disorders; changing patterns of substance abuse including alcohol; increased domestic violence and child abuse. Family relationships, interactions and understanding improved in many but minority had strained dynamics. Vulnerable groups included the elderly, women, youth; children; disabled; frontline and health workers; minorities and severely mentally ill. At the community level, there were signs of collective (mass) hysteria from panic buying to conspiracy theories, public shaming, fake news and disinformation spreading on social media and mass protests. There were also positive effects such as better understanding of bio-knowledge; interventions (rapid vaccine production, contact tracing methods) and discoveries (mRNA Vaccines), health systems improvements (tele-health), online learning, gratitude toward heath care workers, increased social/community/family cohesion, closer international networking, reduction in suicide rates and drop in interstate and civil conflicts, road accidents, crime and communicable diseases with their resultant morbidity, mortality and mental health consequences. Conclusions: In view of the widespread mental health and psychosocial consequences from the COVID-19 pandemic, a community-based approach is suggested while treating more severe mental disorders at the primary care or specialist level.
Vision-based Pakistani Sign Language Recognition Using Bag-of-Words and Support Vector Machines
Authors: Mirza Muhammad Shaheer , Munaf Sheikh Muhammad , Ali Shahid , Azim Fahad , Khan Saad Jawaid 
Published: January 2022

Abstract
In order to perform their daily activities, a person is required to communicating with others. This can be a major obstacle for the deaf population of the world, who communicate using sign languages (SL). Pakistani Sign Language (PSL) is used by more than 250,000 deaf Pakistanis. Developing a SL recognition system would greatly facilitate these people. This study aimed to collect data of static and dynamic PSL alphabets and to develop a vision-based system for their recognition using Bag-of-Words (BoW) and Support Vector Machine (SVM) techniques. A total of 5,120 images for 36 static PSL alphabet signs and 353 videos with 45,224 frames for 3 dynamic PSL alphabet signs were collected from 10 native signers of PSL. The developed system used the collected data as input, resized the data to various scales and converted the RGB images into grayscale. The resized grayscale images were segmented using Thresholding technique and features were extracted using Speeded Up Robust Feature (SURF). The obtained SURF descriptors were clustered using K-means clustering. A BoW was obtained by computing the Euclidean distance between the SURF descriptors and the clustered data. The codebooks were divided into training and testing using 5-fold cross validation. The highest overall classification accuracy for static PSL signs was 97.80% at 750×750 image dimensions and 500 Bags. For dynamic PSL signs a 96.53% accuracy was obtained at 480×270 video resolution and 200 Bags.
WITHDRAWN: Determination of the Effect of Two Different Methods of Dental Anaesthesia on Pain Level in Pediatric Patients: A Cross-Over, Randomised Trial
Authors: Yilmaz Nagehan , Baygin Ozgul , Tüzüner Tamer , Menteşe Ahmet , Demir Selim 
Published: January 2022

Abstract
ObjectiveTo compare intraosseous (IOA) and needle-free dental anaesthesia (NFA) methods that painless anaesthesia.Materials and MethodsTwenty patients aged 8–10 years were included in this cross-over study. To determine the anxiety levels and pain experienced by the patients, Face, Legs, Activity, Cry, Consolability (FLACC) and Frankl Behavioural scales were used. The pulse rate (PR) and salivary opiorphin levels (SOL) determined. The Friedman and Wilcoxon signed-rank tests were used. p<0.01 was considered significant.ResultsAccording to FLACC scores, IOA and NFA exhibited significantly pain alteration patterns in during local and topical anaesthesia, respectively (p=0.004,0.001; p<0.01). Also, only NFA showed significantly decreased SOL values in 5- and 10- minutes after local anaesthesia periods compared to the before levels (p=0.004, p=0.001; p<0.01).ConclusionsPatients feel similar pain perceptions during local anaesthesia application in both injection systems. According to the SOL values, NFA may provide more higher anaesthetic efficiency than IOA.Clinical RelevanceThis study provides to compare two different new anaesthetic systems for pain reduction during local anesthesia for pediatric population.
Importance of Eosinophilic Infiltration of the Colonic Mucosa in Ulcerative Colitis Patients who are Refractory to Maintenance Therapy
Authors: Miyazu Takahiro , Ishida Natsuki , Asai Yusuke , Tamura Satoshi , Tani Shinya , Yamade Mihoko , Hamaya Yasushi , Iwaizumi Moriya , Osawa Satoshi , Furuta Takahisa , baba satoshi , Sugimoto Ken 
Published: January 2022

Abstract
Eosinophilic infiltration is sometimes observed histologically in ulcerative colitis (UC), but the effect of the degree of infiltration on the treatment course for UC is not completely studied. We investigated whether short-term steroid administration in UC patients refractory to maintenance therapy, with high eosinophilic infiltration in the colonic mucosa, contributed to clinical and endoscopic improvement. Ten patients with endoscopically active and pathologically high eosinophilic infiltration, based on pathological examination using endoscopic biopsy, were examined for clinical background when starting steroid treatment; clinical and endoscopic improvement before and after steroid use were assessed prospectively. The average initial steroid dosage and duration of use were 21.0 mg and 102.7 days, respectively. The mean values before and after steroid use of clinical activity index, Mayo endoscopic subscore, and UC endoscopic index of severity were 2.4 and 1.0, 1.8 and 0.7, and 3.9 and 1.1, respectively. All these scores improved significantly after steroid use (P=0.04, P<0.01, P<0.01, respectively). Steroids were discontinued in all patients; no patients required steroid re-administration. There may be cases of UC with eosinophilic infiltration into the colonic mucosa and resistant to maintenance treatment, suggesting that short-term steroid administration may contribute to clinical and endoscopic improvements.
Neuromorphic Chip Integrated with an LSI and Amorphous-metal-oxide Semiconductor Thin-film Synapse Devices
Authors: Kimura Mutsumi , Shibayama Yuki , Nakashima Yasuhiko 
Published: January 2022

Abstract
Artificial intelligences are promising in future societies, and neural networks are typical technologies with the advantages such as self-organization, self-learning, parallel distributed computing, and fault tolerance, but their size and power consumption are large. Neuromorphic systems are biomimetic systems from the hardware level, with the same advantages as living brains, especially compact size, low power, and robust operation, but some well-known ones are non-optimized systems, so the above benefits are only partially gained, for example, machine learning is processed elsewhere to download fixed parameters. To solve these problems, we are researching neuromorphic systems from various viewpoints. In this study, a neuromorphic chip integrated with an LSI and amorphous-metal-oxide semiconductor (AOS) thin-film synapse devices has been developed. The neuron elements are digital circuit, which are made in an LSI, and the synapse devices are analog devices, which are made of the AOS thin film and directly integrated on the LSI. This is the world's first hybrid chip where neuron elements and synapse devices of different functional semiconductors are integrated, and local autonomous learning is utilized, which becomes possible because the AOS thin film can be deposited without heat treatment and there is no damage to the underneath layer, and has all advantages of neuromorphic systems.
Improvement of Dispersibility of Graphene Oxide by Surface Modification with Rare Earths
Authors: Li Yong , Jiang Zhou , Yu Haidong , Zhou Xuebin , Yi Peng 
Published: January 2022

Abstract
Rare earth-modified graphene oxide (RE-M-GO) materials were successfully prepared by infiltration and heating modifier method. The morphology and phase structure of RE-M-GO were characterized by scanning electron microscopy(SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and energy dispersive spectrometer(EDS). The changes of the chemical structure were indicated by Fourier transform infrared (FTIR). X-ray photoelectron spectroscopy(XPS) was used to study the chemical state of the surface elements of graphene oxide which showed that the rare earth elements were added to the graphene oxide functional groups through the coordination reaction. Additionally, the findings concluded that the effect of modification by Ce is more obvious than La elements and the RE-M-GO materials prepared by the heating modifier method had better dispersibility than infiltration. With activating effect, the rare earth elements grafting to graphene oxide will contribute to its combination with other materials.
Angio-Associated Migratory Cell Protein (AAMP) Regulates the Hippo/YAP Pathway and Mitochondrial Functionality to Drive Osteosarcoma Metastasis
Authors: Zhan Fangbiao , Chen Zhiyu , Xie Chaozheng , Xiang Shuang , Deng Qianrong , Li Huanhuan , Tian Lin , Jian Changchun , Xiang Jiangxia , Ou Yunsheng , Chen Jian , Xu Lixin 
Published: January 2022

Abstract
Background: Osteosarcoma (OS) is the prevalent form of primary bone cancer among adolescents, but the 5-year overall survival rate for patients with a metastatic or recurrent OS is under 20%. Angio-associated migratory cell protein (AAMP) is known to be a key regulator of cellular migration, yet its role in the context of OS metastasis has yet to be firmly established.Methods: Bioinformatics analyses were used to explore the association between AAMP and YAP expression and the prognosis of OS patients, and to evaluate differences in AAMP expression in patients with primary OS, recurrent OS, and pulmonary metastatic OS. Immunohistochemical (IHC) staining was additionally performed to compare AAMP levels in primary OS and pulmonary metastatic OS patient samples. Lentiviral transduction was further used to establish OS cell lines in which AAMP or YAP had been stably knocked down or overexpressed. OS cell migration and invasion were assessed using wound healing and Transwell assays. Proteins associated with the mitochondria, the epithelial-mesenchymal transition (EMT), YAP, and its target proteins were assessed in OS cell lines via Western blotting. OS cell lamellipodia were detected via phalloidin staining. Mitochondrial morphological characteristics were assessed via transmission electron microscopy following the knockdown of AAMP. An ATP kit was employed to measure ATP levels in OS cells in which AAMP had been knocked down. Animal model studies were used to confirm indices associated with OS cell lung metastasis following AAMP knockdown. Results: Patients with metastatic OS exhibit higher levels of AAMP expression that are correlated with poorer patient prognosis. Knocking down AAMP suppressed the migratory, invasive, and EMT activity of analyzed OS cell lines. AAMP was found to regulate CFL1 and thereby control OS cell protrusion. AAMP knockdown was further found to promote OS cell mitochondrial dysfunction and decreased intracellular ATP production, with these AAMP knockdown cells exhibiting impaired migratory and invasive activity as a consequence of YAP inhibition. Consistently, the knockdown of AAMP suppressed the in vivo metastasis of OS cells. Conclusions: Together, these data highlight a model wherein AAMP can promote OS cell migratory and invasive activity by regulating YAP and mitochondrial functionality. The AAMP/CFL1/YAP signaling pathway may thus represent a viable therapeutic target for efforts aimed at suppressing the metastatic progression of OS.
Ectonucleotide Pyrophosphatase Phosphodiesterase 1 Is Correlated With Insulin Resistance and Lipid Metabolism Disorders in the Rat Model of Polycystic Ovary Syndrome
Authors: Xia Jing , Yang Yiqing , Yang Zhe , Wu Gengxiang , Yang Jing 
Published: January 2022

Abstract
Previous studies have shown that ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) may be an inhibitor of the insulin signalling pathway, and insulin resistance (IR) is believed to be the core mechanism in the pathophysiology of polycystic ovary syndrome (PCOS). This study was aimed to investigate the expression of ENPP1 in different tissues of PCOS rats and to analyse its potential role in the pathophysiology of PCOS. Eighteen 23-day-old Sprague-Dawley rats were divided into PCOS and control groups (n= 9/group). Samples were collected after 20 days. Pathological examination and immunofluorescence were performed. Western blotting results of ENPP1 in the ovaries were analysed. Serum levels of ENPP1, hormones, fasting blood glucose (FBG), serum lipids were measured. Levels of ENPP1, testosterone (T), FBG, fasting insulin (FINS), homeostasis model assessment of IR (HOMA-IR), free fatty acids (FFAs), leptin, cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) were significantly higher in PCOS group, while adiponectin (ADP) and high-density lipoprotein cholesterol (HDL-C) were significantly lower. Spearman’s rank correlation analysis showed that ENPP1 was correlated with T, HOMA-IR, FFAs, leptin, serum lipids and ADP. MRNA levels of ENPP1, BAX, and IRS1 were higher in the ovaries, skeletal muscle, subcutaneous fat, and visceral fat of PCOS rats, and the protein expression of ENPP1 was significantly higher in the ovaries. Our results revealed that ENPP1 is highly associated with IR and lipid metabolism-related molecules, which may have play important roles in PCOS pathophysiological changes.