bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-Formimidoylation/-iminoacetylation requires a specialized enzyme employing FAD-dependent and ligand-protein NOS bridge dual chemistry
Authors: Li Tsung-Lin , Wang Yung-Lin , Chang Chin-Yuan , Hsu Ning-Shian , Lo I-Wen , Lin Kuan-Hung , Chen Chun-Liang , Chang Chi-Fon , Wang Zhe-Chong , Ogasawara Yasushi , Dairi Tohru , Maruyama Chitose , Hamano Yoshimitsu 
Published: October 2022

Abstract
Oxidized cysteine residues are highly reactive and may form covalent conjugates with other residues in proteins to enable proper functionalities, for example, the lysine-cysteine NOS bridge identified recently as an allosteric redox switch. To our knowledge, the NOS-covalent species per se directly engaging in reactions has not been previously demonstrated. Here, we report a non-canonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycinothricin forming BD-12, an enzymatic process demanding a cascade of delicate chemical reactions. To illustrate how it proceeds, we pursed X-ray crystallography whereby crystal complexes display two tetrameric oligomers in an asymmetric unit. Unlike canonical FAD-dependent oxidoreductases, two substrate-binding sites that sit 13.5 Å apart were uncovered one for glycine and the other for glycinothricin/glycylthricin. An intermediate-enzyme adduct in an NOS-covalent linkage was spotted at the latter, where it acts as though a two-scissile-bond linkage rod permits nucleophilic addition and cofactor-free decarboxylation reactions to take place. The chain length of nucleophilic acceptors contends with bond cleavage sites at either N–O or O–S accounting for N-formimidoylation or -iminoacetylation. The resultant is no more sensitive to aminoglycoside-modifying enzymes, an acute strategy that antibiotic-producing species employs to reinvigorate its armory countering drug resistance of competing species.
Synthesis and Characterization of Iron Doped Hydroxyapatite for Defluoridation of Water and Antibacterial Activity
Authors: Temtime Abebe Awulew , Zereffa Enyew Amare , Leku Dereje Tsegaye 
Published: October 2022

Abstract

Fluoride contaminated drinking water is a major concern due to its negative health effects experienced by people in many parts of the world. This study focused on the synthesis of HAp and Fe doped HAp from diammonium hydrogen phosphate (DAP), calcium and iron precursors using urea as fuel for defluoridation of water and antibacterial activities. The synthesis of HAp and Fe doped HAp were characterized by using thermogravimetric analysis; scanning electron microscopy, X-ray diffraction, and Fourier transform Infrared spectroscopic techniques. An average crystallite size of HAp and Fe doped HAp were 32.54 nm and 27.91 nm, respectively, showing Fe doping results in a decrease in crystallite size. Batch adsorption studies were performed to investigate the adsorption capacity and removal efficiency of hydroxyapatite such as the effect of the initial pH of the solution, contact time, adsorbent dose and initial fluoride concentration. The adsorption data were fitted by Freundlich isotherm model and pseudo second order kinetic. In real water samples, the maximum removal efficiency of fluoride was observed to be 82.9 % with 4.2 mg/g maximum adsorption capacity under the optimum conditions which indicated that the prepared hydroxyapatite can be used as adsorbents for the removal of fluoride from contaminated real water with good efficiency. The antibacterial activities of the synthesized HAp and Fe doped HAp were tested against gram-negative bacterial strains E. coli and against gram-positive bacterial strains S. aureus using disc diffusion method. The maximum inhibition zone of gram-negative bacterial strains E. coli was 11 mm for both HAp and Fe doped HAp.
Bayesian hypothesis testing reveals that reproducible models in Systems Biology get more citations
Authors: Höpfl Sebastian , Pleiss Jürgen , Radde Nicole 
Published: October 2022

Abstract
Many measures have been taken to develop data and modeling standards towards a F.A.I.R. data and model management by the Systems Biology community. Still, there is an ongoing debate about incentives and merits for the individual researcher to make their research results reproducible. Here, we pose the specific question whether reproducible models have higher impact in terms of citations. Therefore, we statistically analyze 328 published models which were recently classified by Tiwari et al. based on their reproducibility. For hypotheses testing, we use a flexible Bayesian approach that provides full distributional information for all quantities of interest and can handle outliers. The results show that in the period from 2013, i.e. 10 years after the introduction of SBML, to 2020, the group of reproducible models is significantly more cited than the non-reproducible group. We show that this effect is not explained by differences in journal impact factors and that it increases with additional standardization of data and error model integration via PEtab. Overall, our statistical analysis demonstrates long-term merits of reproducible modeling for the individual researcher in terms of citations. Moreover, it provides evidences for an increased use of reproducible models in the scientific community.
The use of impulse oscillometry system for monitoring of lung mechanics during covid-19 pneumonia
Authors: Taivans Immanuels , Grima Laura , Zvaigzne Ligita , Jurka Normunds , Gordjusina Valentina , Strazda Gunta 
Published: October 2022

AbstractForced oscillation technique (FOT) is non-invasive method, that does not require the patient's participation and allows to evaluate lung and airways mechanics. The question addressed by the study is whether Computerized Tomography (CT) and FOT data correlate between and whether FOT allows to follow up the course of covid-19 pneumonia during the acute intrahospital and recovery period. Material, patients and methods In the study were involved 30 intrahospital treated spontaneously breathing, oxygen dependent patients with moderate severity SARS-CoV-2 induced pneumonia. (CT) scans were quantitatively assessed by CT-scoring method. During the hospital stay and 3 months after the discharge lung function was measured by FOT method. Results During acute period resistance values R5 and R5-20 were elevated above the upper limit of normal (ULN) in 28% and 50% of all patients respectively. Reactance indices X5, AX and Fres exceeded ULN in 55%, 68% and 66% of cases. Significant correlations were observed between PaO2/FiO2, the time spent in the hospital and R5, X5, AX and Fres expressed as % of predicted. Significant correlations between FOT indices and CT-score was not found. After 3 months 18 patients were compared. R5-20 from 316;-171/+583 decreased to 122;- 56/+266% pred. P = 0,0075. AX from 448;- 275/+731 decreased to 213;- 131/+347% pred,p = 0,0112 and Fres from 171;- 143/+200 to 130;- 110/+150%pred, p = 0,0081. Study has shown that FOT method reliably reflects the pathological changes in lung mechanics and allows to monitor the course of covid-19 disease, but it cannot substitute for CT.
Vector coding reveals the underlying balance control strategies used by humans during translational perturbation
Authors: Taleshi Naser , Brownjohn James , Lamb Sarah E , Zivanovic Stana , Williams Genevieve 
Published: October 2022

Abstract

Postural control research has mainly focused on standing balance experiments on a platform moving with relatively large amplitudes (0.1-0.2 m). To broaden knowledge about postural coordination, this study investigated balance strategies while standing on a platform moving in the anterior-posterior direction and whose frequency was scaled linearly from 0.4-6 Hz at a small amplitude of 2 mm peak. The coordination between hip, knee, and ankle joint torque, and centre of mass (COM) and centre of pressure (COP) motion was quantified by vector coding (VC) method to define the local and global strategy, respectively. VC revealed that at lower frequencies, an ankle strategy was recruited which induced an in-phase COPCOM motion with COP dominancy. As platform frequency reached a critical value, the transition frequency, COM dominated over COP and an anti-phase torque occurred between the knee and ankle, called a knee strategy. The knee strategy related to an anti-phase motion between the COP and COM and allowed the COP to regain its dominance over COM. Collectively, this work revealed the knee strategy as a new balance control strategy relevant in real-life settings, and a transition between ankle and knee strategies that underpinned a transition between COP-COM relative motion.
Redox Control as a Target for Anticancer Drug Development
Authors: Kirkpatrick D. L. 
Published: October 2022

Abstract:
Cells maintain an intracellular environment that is reducing in the face of an oxidizing extracellular environment. Regulated alterations in the intracellular redox state (redox signalling) can modulate events such as DNA synthesis, enzyme activation. selective gene expression and regulation of the cell cycle. The primary consequence ol intracellular redox signalling is a change in the oxidation state of cysteine residues ol key proteins.
This review will examine a number of the cellular redox systems which are in place It' control the redox state, including such proteins as glutathione and glutathione reductase. thioredoxin and thioredoxin reductase, the highly cysteine rich, metalothioneins and the
Ref-I protein which plays a role in the activity of AP-I and NF-KB. Signalling processes will be: iJ.:111ificd which are dependent on the redox state of controlling proteins and are potential targets for drug development and include transcription factors whose activation is a prerequisite for growth factor stimulated growth. The development of drugs which exploit the cellular redox state has grown dramatically over the last few years as the understanding of cellular redox has burgeoned. This review will attempt to present the current state of knowledge of agents in this category including those which exploit the hypoxic cellular environment, those which participate through antioxidant pathways and the evolving area of interest involving agents which alter the signalling process through protein thioalkylation.
The Concept of National Identity in the Artwork of Female Artists in Malaysia
Authors: Zakaria Salehuddin , Legino Rafeah , Abdul Aziz Mohammad Kamal 
Published: October 2022

This study examines the national identity elements of the Fatimah Chik and Khatijah Sanusi artworks, which begins with the examination of relevant material, including examples of national identity-related works and visual data on the results of Malaysian female artists obtained through digital photographs and records. Identifying and recognising national identity in Malaysian female artists' works is categorised by the artwork's profile. The artwork's focus and criteria will be mapped with the inquiry of the National Cultural Congress's study (NCC). Women's attitudes in art production reflect national identity in female artists' artworks that emphasise culture, family, and accuracy.
Keywords: Artworks, Female artist, National identity, Malaysia
eISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under the responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7iSI8.3918
Assessment of the possibility of using various fire extinguishing means in high-rise buildings
Authors: Aleshkov M. V. , Dvoenko O. V. , Gumirov A. S. , Sokovnin A. I. , Seregin M. V. , Semenyuk I. O. , Tsarichenko S. G. 
Published: October 2022

Introduction. To date, fires in high-rise buildings are one of the significant problems faced by fire protection units. Unique objects require a special approach in terms of fire safety and fire extinguishing. The most important task is to ensure the supply of extinguishing agents to the height using modern fire-fighting equipment and installations.Materials and methods.In September 2021, to conduct experimental scientific and tactical exercises on the roof of the Neva Towers tower, a program and methodology for supplying fire extinguishing agents in various ways to the height were developed. The following methods of feeding to height were considered: deployment using the equipment of a container for high-altitude firefighting, feeding from an installation with compression foam technology, feeding using a waterjet cutting unit “Cobra”.Theoretical bases. A theoretical assessment of the possibility of supplying extinguishing agents to a height with the help of new fire-rescue equipment confirmed the need for experimental scientific and tactical exercises on the roof of the Neva Towers tower.Results and discussions. As a result of the scientific and tactical exercises, the effectiveness of the use of new fire extinguishing systems with compression foam supply, as well as installations with waterjet cutting technology “Cobra” was proved. It was possible to provide a feed to a height of 350 m.Conclusions. To date, with the help of new fire extinguishing technologies, it has been experimentally proven that their use is most effective compared to “traditional” methods of supplying extinguishing agents. In the future, it is necessary to conduct more detailed studies of the hydrodynamic parameters of pumping and bag systems in order to develop recommendations for preliminary planning of the actions of forces and means of fire and rescue units.
Association between SGLT2 inhibitor treatment and diabetic ketoacidosis and mortality in people with type 2 diabetes admitted to hospital with COVID-19
Authors: Khunti Kamlesh , Ruan Yue , Davies Jim , Field Benjamin C.T , Harris Sophie , Kosiborod Mikhail , Nagi Dinesh , Narendran Parth , Patel Dipesh , Ryder Robert E.J. , Várnai Kinga A , Wild Sarah H. , Wilmot Emma G. , Rea Rustam 
Published: October 2022

<p> </p>
<p><em><strong>Objective </strong></em></p>
<p>To determine the association between prescription of SGLT2 inhibitors and diabetic ketoacidosis (DKA) incidence or mortality in people with type 2 diabetes hospitalized with COVID-19. </p>
<p><em><strong>Research Design and Methods </strong></em></p>
<p>This was a retrospective cohort study based on secondary analysis of data from a large nationwide audit from a network of 40 centres in United Kingdom with data collection up to December 2020 that was originally designed to describe risk factors associated with adverse outcomes among people with diabetes who were admitted to hospital with COVID-19.. The primary outcome for this analysis was DKA on or during hospital admission. The secondary outcome was mortality. Crude, age-sex adjusted and multivariable logistic regression models, were used to generate odds ratios and 95% confidence intervals for people prescribed SGLT2 inhibitor compared to those not prescribed SGLT2 inhibitor. </p>
<p><em><strong>Results</strong></em> </p>
<p>The original national audit included 3067 people with type 2 diabetes who were admitted to hospital with COVID-19, of whom 230 (7.5%) were prescribed SGLT2 inhibitors prior to hospital admission. Mean (SD) age of the overall cohort was 72 years, 62.3% were men and 34.9% were prescribed insulin. Overall, 2.8% of the total population had DKA and 35.6% people died. The adjusted odds of DKA were not significantly different between those prescribed SGLT2 inhibitors and those not (OR 0.56, 0.16-1.97). The adjusted odds of mortality associated with SGLT2 inhibitors were similar in the total study population (OR 1.13, 0.78-1.63 ), in the sub-group prescribed insulin (OR 1.02, 0.59-1.77), and in the sub-group that developed DKA (OR 0.21, 0.01-8.76). </p>
<p><em><strong>Conclusions</strong></em></p>
<p>We demonstrate a low risk of DKA and high mortality rate in people with type 2 diabetes admitted to hospital with COVID-19 and limited power but no evidence of increased risk of DKA or in-hospital mortality associated with prescription of SGLT2 inhibitors. </p>
A review on electrical vehicle adaptation in India
Authors: Manikandan B. , Gudipalli Abhishek 
Published: October 2022

Abstract
This paper reviews the battery technology, methods of charging techniques for charging the EV's battery, factors affecting the EV adaptation, India. Many significant methods recently used in electric vehicles are explained. In India, it has taken a major step in adapting the electric vehicle employing the Faster Adoption and Manufacturing of (Hybrid &) Electric Vehicles in India (FAME) scheme a government initiative. In the forthcoming years, electrification of transportation networks is a basic one while considering the consumption of petroleum derivatives just for the 50 years. Transportation is the most important source of logistics, and people contribute significant primary emissions to global warming, so avoid this situation by focusing on zero emissions. Transportation by electric vehicle is the lone achievable answer for these issues. This paper presents the effect of quick charging on Lithium-ion batteries in EVs. The Lithiumion battery is utilized to be essential energy for electric vehicle driving objective and characterized in high volume per energy density. The plan of the battery charging station is utilized to discover the gas volume of the lithium-ion battery component from the electric vehicles. In the final, it points out the future potential research with respect to electric vehicle innovation and how to grow the charging infrastructure for EVs. Also including the developments need and improvements.
Effect of Host Size on Susceptibility of Melanotus communis (Coleoptera: Elateridae) Wireworms to Entomopathogens
Authors: Williams Livy , Cherry Ron , Shapiro-Ilan David 
Published: October 2022

Abstract
Wireworms, the soil-borne larvae of click beetles (Coleoptera: Elateridae), are important crop pests throughout the world. In the eastern U.S., Melanotus communis larvae attack grain, root/ tuber, and vegetable crops. Our objectives were to characterize the pathogenicity and virulence of fungal and nematode entomopathogens on M. communis wireworms, and determine if wireworm size affected virulence. Pathogens tested included five entomopathogenic nematodes, Steinernema carpocapsae (All strain), S. feltiae (SN strain), S. riobrave (355 strain), Heterorhabditis bacteriophora (VS strain), and H. indica (HiHom1 strain); and two entomopathogenic fungi, Beauveria bassiana (GHA strain) and Cordyceps javanica (WF-GA17 strain). None of the pathogens tested caused >15% mortality at 7 or 14 days post-inoculation. Mortality was highest in S. carpocapsae (All strain); the other entomopathogens did not cause higher mortality than the untreated control. Overall, smaller wireworms were more susceptible than larger wireworms. Our results suggested that M. communis wireworms have defenses that limit the ability of the entomopathogens we tested to infect the wireworms. Conceivably, other entomopathogen strains or species may be more effective. Natural populations of entomopathogens may contribute to wireworm population reduction, but further studies are warranted before entomopathogens can be used for M. communis management.
A Draft Mitogenome of Plectus murrayi
Authors: Xue Xia , Adams Byron J. , Dilman Adler R. 
Published: October 2022

Abstract

Plectus murrayi is a free-living microbivorous nematode endemic to Antarctic soils. Our draft assembly of its mitogenome was 15,656 bp long, containing 12 protein-coding, eight transfer RNA (tRNA), and two ribosomal RNA (rRNA) genes. Mitophylogenomic analyses extend our understanding of mitochondrial evolution in Nematoda
Mycotic clival osteomyelitis secondary to immunosuppression by SARS-CoV-2
Authors: Delgado-Arce Julio César , Becerra-Arciniega Fabiola Alejandra , Escamilla-Chávez Elizabeth , VelascoTorres Hector Sebastián , Guerrero-Suarez Pablo David , Mártinez-Anda Jaime Jesús 
Published: October 2022

Background:
During the past 2 years, the use of systemic corticosteroids has increased due to COVID-19 atypical pneumonia management. Similarly, an increase in mycotic infection cases has been reported during the same period as a consequence of immunosuppression caused by corticosteroid overuse. Mycotic clival osteomyelitis is a rare clinical entity which presumably has increased its incidence during the pandemic.

Case Description:
A 52-year-old woman who presented persistent headaches and unexplained weight loss after being hospitalized due to COVID-19 pneumonia treated with intravenous corticosteroids. Head computed tomography and magnetic resonance imaging showed extensive osteomyelitis at the clival region with no brain parenchyma involvement. Surgical excision through navigation-guided transnasal transclival endoscopic extended approach was performed for surgical debridement. Histopathological analysis revealed angulated hyphae, suggestive of Aspergillosis. Systemic antifungal treatment was administered for 30 consecutive days. Afterward, she was discharged without any remarkable neurological findings, reassessed during follow-up.

Conclusion:
The COVID-19 pandemic has had an effect on the reemergence of mycotic infections due to corticosteroid immunosuppression. Clival osteomyelitis secondary to mycotic infection is an exclusion diagnosis that we encourage to be highly suspected within the persisting COVID-19 pandemic.
Notes on the Birds of Central Oaxaca, Part I: Podicipedidae to Laridae
Authors: Forcey John M. 
Published: October 2022

Notas sobre las aves de Oaxaca central, parte I: Podicipedidae a LaridaeSe reportan nuevos datos que amplían y clarifican nuestro conocimiento del estatus y distribución de 67 especies de aves en la región central del Estado de Oaxaca. Las observaciones se realizaron abarcando partes de los distritos de Etla, Ixtlan, Tlacolula, y Zaachila dentro de un círculo de 35 km alrededor de la Ciudad de Oaxaca. El reporte se basa en observaciones tomadas durante 728 días, comprendidos entre diciembre 1996 y diciembre 2001. Los hábitats principalmente visitados fueron pino-encino (incluyendo zonas pequeñas de pino-encino-oyamel y pino-encino mezclado con pastizales), matorral de encino, matorral subtropical, vegetación riparia, y vegetación secundaria, campos agrícolas y otros (incluyendo áreas urbanas, jardines, y parques). Las siguientes especies se reportan por primera vez en la zona: Pelecanus erythrorhynchos, Egretta tricolor, Eudocimus albus, Dendrocygna autumnalis, Dendrocygna bicolor, Porphyrula martinica, Charadrius semipalmatus, Recurvirostra americana, Jacana spinosa, Calidris pusilla, Calidris mauri, Phalaropus lobatus y Sterna forsteri. Las siguientes cuatro especies se reportan por primera vez como residentes en apareamiento en el área: Tachybaptus dominicus, Elanus leucurus, Ortalis poliocephala y Gallinula chloropus.
The first record of Corvus cryptoleucos from Baja California Sur, Mexico
Authors: Dinets Vladimir 
Published: October 2022

Primer registro de Corvus cryptoleucos en Baja California Sur, MéxicoEsta nota reporta el primer registro de Corvus cryptoleucos en la Península de Baja California. La especie fue reportada sólo previamente presente en México continental y el suroeste de Estados Unidos de Norte América.