bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organic Anisotropic Excitonic Optical Nanoantennas
Authors: Kang Evan S. H. , KK Sriram , Jeon Inho , Kim Jehan , Chen Shangzhi , Kim Kyoung‐Ho , Kim Ka‐Hyun , Lee Hyun Seok , Westerlund Fredrik , Jonsson Magnus P. 
Published: May 2022

AbstractOptical nanoantennas provide control of light at the nanoscale, which makes them important for diverse areas ranging from photocatalysis and flat metaoptics to sensors and biomolecular tweezing. They have traditionally been limited to metallic and dielectric nanostructures that sustain plasmonic and Mie resonances, respectively. More recently, nanostructures of organic J‐aggregate excitonic materials have been proposed capable of also supporting nanooptical resonances, although their advance has been hampered from difficulty in nanostructuring. Here, the authors present the realization of organic J‐aggregate excitonic nanostructures, using nanocylinder arrays as model system. Extinction spectra show that they can sustain both plasmon‐like resonances and dielectric resonances, owing to the material providing negative and large positive permittivity regions at the different sides of its exciton resonance. Furthermore, it is found that the material is highly anisotropic, leading to hyperbolic and elliptic permittivity regions. Nearfield analysis using optical simulation reveals that the nanostructures therefore support hyperbolic localized surface exciton resonances and elliptic Mie resonances, neither of which has been previously demonstrated for this type of material. The anisotropic nanostructures form a new type of optical nanoantennas, which combined with the presented fabrication process opens up for applications such as fully organic excitonic metasurfaces.
Sustainable Upcycling of Spent Lithium‐Ion Batteries Cathode Materials: Stabilization by In Situ Li/Mn Disorder
Authors: Lin Jiao , Fan Ersha , Zhang Xiaodong , Li Zhujie , Dai Ying , Chen Renjie , Wu Feng , Li Li 
Published: May 2022

AbstractThe non‐destructive repair of spent lithium‐ion batteries cathode materials has been the holy grail in the field of waste‐to‐resource research due to the potential for optimal environmental and economic benefits. Here, Mn deficiency and cationic disorder in degraded materials are discovered for the first time and the degraded crystal structure is repaired by the in situ upcycling process using a low‐carbon and economical technique. The repaired disordered LiMn2O4 (LMO) material can contribute higher capacity and greater stability than ordered LMO materials. This unexpected behavior is attributed to the in‐situ upcycling process that enhances the Li/Mn atomic disorder, thereby altering the electrochemical activity as well as the structural stability of the cathode material. Specifically, the Li/Mn disorder can effectively suppress the Jahn–Teller distortion and two‐phase phase transition and activate the activity of disordered Li, contributing to a stable high discharge capacity of upcycled material. The discovery of the Mn‐deficiency mechanism solves many doubts as to the conventional repair technology and can provide a more adequate theoretical guidance of the development of recycling technology together with the Li‐deficiency mechanism. The atomic disorder structure also provides guidance for the design of battery materials and promotes the sustainable development of future green lithium‐ion batteries.
High and normal oleic runner‐type peanut cultivar by year effects on seed germination and vigor response to temperature
Authors: Hurdle Nicholas L. , Grey Timothy L. , Branch William D. , Monfort W. Scott 
Published: May 2022

AbstractExperiments conducted from 2013 to 2018 evaluated the cultivar by year effects on breeder seed germination and vigor of five high oleic (HO) and five normal oleic (NO) runner‐type peanut (Arachis hypogaea L.) cultivars grown under similar production practices. Seed germination and vigor were evaluated using a thermal gradient at temperatures of 12–36 °C (1.0 °C increments) over 7 d, and included growing degree day (GDD) accumulation. Germination across 6 yr of seed testing over all temperatures were phenotypically similar for HO's: Florida‐07 (59–86%), FloRun 107 (71–85%), Georgia‐09B (73–87%), Georgia‐14N (58–79%), Georgia‐13M (72–88%) and NO's: Georgia‐06G (65–88%), Georgia Greener (65–86%), Tifguard (65–85%), Georgia‐12Y (61–83%), and Georgia‐07W (60–91%). Lorentzian distribution models established the temperature and time (hours) to maximum germination. Analysis indicated the maximum germination across all temperatures: Georgia‐14N (HO) 50.5 h < Georgia Greener (NO) 53.2 h < Tifguard (NO) 54.4 h < Georgia‐07W (NO) 54.6 h < Georgia‐13M (HO) 56.5 h < Georgia‐06G (NO) 58.9 h < Georiga‐09B (HO) 60.4 h < Florida‐07 (HO) 67.8 h < FloRun 107 (HO) 69.7 h < Georgia‐12Y (NO) 72.0 h. Peanut cultivar vigor varied by year with respect to overall GDDs to reach Germ80 and maximum germination (b0). Overall vigor was similar for HO and NO runner‐type peanut cultivars. Peanut seed were consistent in germination, Germ80, and b0 among the 10 evaluated cultivars over the 6 yr of testing.
Evolution and development of inflorescences and floral symmetry in Solanaceae
Authors: Zhang Jingbo , Stevens Peter F. , Zhang Wenheng 
Published: May 2022

AbstractPremiseThe inflorescences of Solanaceae are unique and complex, which has led to long‐standing disputes over floral symmetry mainly due to different interpretations of the cyme‐like inflorescence structure. The main disagreements have been over how the phyllomes associated with the flower were arranged relative to the inflorescence axis especially during early flower initiation.MethodsHere we investigated the evolution of inflorescences in Solanaceae by analyzing inflorescence structure in the context of phylogeny using ancestral state reconstruction (ASR) to determine the evolutionary transitions between loosely arranged and tightly clustered inflorescences and between monochasial‐like and dichasial‐like cymes. We also reconstructed two‐ and three‐dimensional models for 12 solanaceous species that represent both inflorescence and phylogenetic diversity in the family.ResultsOur results indicate that the most recent common ancestor of Solanaceae had a loosely arranged and monochasial‐like cyme, while tightly clustered inflorescences and dichasial‐like cymes were derived. Compared to the known process of scorpioid cyme evolution, Solanaceae achieved their scorpioid cyme‐like inflorescences through a previously undescribed way. Along the pedicel, the two flower‐preceding prophylls are not in the typical transverse position of dicotyledonous plants; they frequently have axillary buds, and the main inflorescence axis continues in a sympodial fashion. As a result, the plane of symmetry of the flower is 36° from the median, and the inflorescence axis and the two flower‐preceding prophylls are symmetrically located along that plane.ConclusionsA better understanding of the morphological evolution of solanaceous inflorescence structure helped clarify the floral symmetry of Solanaceae.
A homozygous exonic variant leading to exon skipping in ABCC8 as the cause of severe congenital hyperinsulinism
Authors: Reyes Diaz Jacqueline V. , Jin Yulin , Garber Kathryn , Cossen Kristina M. , Li Yujing , Jin Peng , Li Hong , Ham Jee‐Young Nina 
Published: May 2022

AbstractCongenital hyperinsulinism (CHI) is genetically heterogeneous, caused by pathogenic variants in multiple known genes regulating insulin secretion from the pancreatic β‐cells. The ABCC8 gene encodes the sulfonylurea receptor 1 (SUR1), a key player in insulin secretion, and pathogenic variants in ABCC8 are the most common cause of CHI. With increased application of genetic testing in clinical practice, variants of unknown clinical significance (VUS) are commonly reported. Additional functional investigation for variant pathogenicity is fundamental in establishing definitive molecular diagnosis and in guiding clinical management. However, due to the lack of ubiquitous tissue expression of these genes, obtaining functional studies on affected tissue has been challenging. We present a case of severe congenital hyperinsulinism which required a near‐total pancreatectomy. CHI gene sequencing identified a homozygous silent variant in ABCC8 located on the last nucleotide of exon 38, c.4608G>A (p.Ala1536Ala). The total RNA was isolated from pancreas resected at the time of pancreatectomy. RNA sequencing and expression analysis demonstrated exon 38 skipping and decreased RNA expression, which supports the pathogenicity of this variant. This case highlights the feasibility of functional studies of VUS on resected pancreatic tissue. The result expands the mutation spectrum in ABCC8 and allows precise genetic counseling to affected families.
Intramolecular C−H Activation as an Easy Toolbox to Synthesize Pyridine‐Fused Bipolar Hosts for Blue Organic Light‐Emitting Diodes
Authors: Wang Fei , Zhang Luoqiang , Han Weiguo , Bin Zhengyang , You Jingsong 
Published: May 2022

AbstractThe development of high‐performance blue organic light‐emitting diodes (OLEDs) remains a challenging task. While exploiting new blue emitters has attracted great interest, developing host materials that considerably determine device performance obviously lags behind. Herein, we present an ease of access to the structurally diverse benzoheteroaromatic‐fused pyridine skeletons by the iridium‐catalyzed intramolecular C−H/C−H coupling reaction, which unlocks an unparalleled opportunity to rapidly assemble a library of pyridine‐fused bipolar host materials. As an illustrated example, the benzo[4,5]thieno[2,3‐b]pyridine skeleton (BTP) has been made to a pseudo‐symmetric host (DCz‐BTP). The merging of a pyridine fragment enables strong intermolecular interactions, leading to satisfactory bipolar transporting properties. Utilizing DCz‐BTP as the host, blue thermally activated delayed fluorescent OLEDs (TADF‐OLEDs) exhibit a low turn‐on voltage of 2.8 V and a high maximum external quantum efficiency (EQEmax) of 29.0 % and blue TADF‐sensitized florescent OLEDs (TSF‐OLEDs) give an EQEmax as high as 20.5 %, revealing the potential of the BTP skeleton for the construction of high‐performance host materials.
Efficiently selective extraction of iron (III) in an aluminum‐based metal–organic framework with native N adsorption sites
Authors: Wang Xu , Long Haijun , Li Lu , Zhan Li , Zhang Xin , Cui Hengqing , Shen Jun 
Published: May 2022

AbstractSeparation and recovery of metal ions from wastewater is greatly significant because of the non‐negligible harm of heavy metal ions in water to human health and environment. A water‐stable aluminum‐based metal–organic framework material (MOF‐303) with native N adsorption sites is proposed for the selective adsorption and separation of the mixture with heavy metal ions (Fe3+ and Cr3+). This type of material comprises the native N adsorption sites, evenly distributing on the organic linking group. It means that the adsorbent has a smoother transport channel for metal ion, resulting in high adsorption capacity and selectivity. The single‐component adsorption results show that MOF‐303 has excellent adsorption capacity for Fe3+, up to a maximum adsorption capacity of 104 mg·g−1, which is about 5 times more than the counterpart capacity of Cr3+. Comprehensive separation studies show that the separation of the mixture with these ions can be achieved in the pH range of 1–3, and the selective adsorption is the most efficient. During 30 min of adsorption process, the removal rate of Fe3+ can be attained by 90%. And the adsorption property of this material can be recovered effectively through pickling process. In addition, the adsorption mechanism of MOF‐303 is characterized by zeta potential analysis, X‐ray photoelectron spectroscopy (XPS), and Fourier transform infrared (FT‐IR). Our work shows that MOF‐303 is not only a promising material for effective separation of Fe3+ from industrial wastewater but also providing a new perspective the specific adsorption capacity of MOF materials.
Acute toxicity and antitumor potential of 1,3,4‐trisubstituted‐1,2,3‐triazole dhmtAc‐loaded liposomes on a triple‐negative breast cancer model
Authors: Ramos Jonas P. , Abdel‐Salam Mostafa A. L. , Nobre Daniel A. B. , Glanzmann Nicolas , de Souza Camila P. , Leite Elaine A. , de Abreu Teles Pedro P. , Barbosa Alan S. , Barcelos Luciola S. , dos Reis Diego C. , Cassali Geovanni D. , de Lima Maria E. , de Castro Quênia J. T. , Grabe‐Guimarães Andrea , da Silva Adilson D. , de Souza‐Fagundes Elaine M. 
Published: May 2022

AbstractFor the first time, compounds developed from the 1,2,3‐triazole scaffold were evaluated as novel drugs to treat triple‐negative breast cancer (TNBC). Four organic salts were idealized as nonclassical bioisosteres of miltefosine, which is used in the topical treatment for skin metastasizing breast carcinoma. Among them, derivative dhmtAc displayed better solubility and higher cytotoxicity against the human breast adenocarcinoma cell line and mouse 4T1 cell lines, which are representatives of TNBC. In vitro assays revealed that dhmtAc interferes with cell integrity, confirmed by lactate dehydogenase leakage. Due to its human peripheral blood mononuclear cell (PBMC) toxicity, dhmtAc in vivo studies were carried out with the drug incorporated in a long‐circulating and pH‐sensitive liposome (SpHL‐dhmtAc), and the acute toxicity in BALB/c mice was determined. Free dhmtAc displayed cardiac and pulmonary toxicity after the systemic administration of 5 mg/kg doses. On the other hand, SpHL‐dhmtAc displayed no toxicity at 20 mg/kg. The in vivo antitumor effect of SpHL‐dhmtAc was investigated using the 4T1 heterotopic murine model. Intravenous administration of SpHL‐dhmtAc reduced the tumor volume and weight, without interfering with the body weight, compared with the control group and the dhmtAc free form. The incorporation of the triazole compound in the liposome allowed the demonstration of its anticancer potential. These findings evidenced 1,3,4‐trisubstituted‐1,2,3‐triazole as a promising scaffold for the development of novel drugs with applicability for the treatment of patients with TNBC.
The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Management and Monitoring of the Interleukin‐1 Mediated Autoinflammatory Diseases: Cryopyrin‐Associated Periodic Syndromes, Tumour Necrosis Factor Receptor‐Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Interleukin‐1 Receptor Antagonist
Authors: Romano Micol , Arici Z. Serap , Piskin David , Alehashemi Sara , Aletaha Daniel , Barron Karyl , Benseler Susanne , Berard Roberta A. , Broderick Lori , Dedeoglu Fatma , Diebold Michelle , Durrant Karen , Ferguson Polly , Foell Dirk , Hausmann Jonathan S. , Jones Olcay Y. , Kastner Daniel , Lachmann Helen J. , Laxer Ronald M. , Rivera Dorelia , Ruperto Nicolino , Simon Anna , Twilt Marinka , Frenkel Joost , Hoffman Hal M. , de Jesus Adriana A. , Kuemmerle‐Deschner Jasmin B. , Ozen Seza , Gattorno Marco , Goldbach‐Mansky Raphaela , Demirkaya Erkan 
Published: May 2022

BackgroundThe interleukin‐1 (IL‐1) mediated systemic autoinflammatory diseases, including the cryopyrin‐ associated periodic syndromes (CAPS), tumour necrosis factor receptor‐associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD) and deficiency of the IL‐1 receptor antagonist (DIRA), belong to a group of rare immunodysregulatory diseases that primarily present in early childhood with variable multiorgan involvement. When untreated, patients with severe clinical phenotypes have a poor prognosis, and diagnosis and management of these patients can be challenging. However, approved treatments targeting the proinflammatory cytokine IL‐1 have been life changing and have significantly improved patient outcomes.ObjectiveTo establish evidence‐based recommendations for diagnosis, treatment and monitoring of patients with IL‐1 mediated autoinflammatory diseases to standardise their management.MethodsA multinational, multidisciplinary task force consisting of physician experts, including rheumatologists, patients or caregivers and allied healthcare professionals, was established. Evidence synthesis, including systematic literature review and expert consensus (Delphi) via surveys, was conducted. Consensus methodology was used to formulate and vote on statements to guide optimal patient care.ResultsThe task force devised five overarching principles, 14 statements related to diagnosis, 10 on therapy, and nine focused on long‐term monitoring that were evidence and/or consensus‐based for patients with IL‐1 mediated diseases. An outline was developed for disease‐specific monitoring of inflammation‐induced organ damage progression and reported treatments of CAPS, TRAPS, MKD and DIRA.ConclusionThe 2021 EULAR/American College of Rheumatology points to consider represent state‐of‐the‐art knowledge based on published data and expert opinion to guide diagnostic evaluation, treatment and monitoring of patients with CAPS, TRAPS, MKD and DIRA, and to standardise and improve care, quality of life and disease outcomes.
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle
Authors: V. Ganesh Goutham , Ganesan Kumar , Xu Baojun , Ramkumar Kunka Mohanram 
Published: May 2022

AbstractThe wide anatomical distribution of macrophages and their vast array of functions match various polarization states and their involvement in homeostasis and disease. The confluence of different cellular signaling networks, including direct involvement in inflammation, at the doorstep of the transcription factor Nuclear Factor‐ erythroid (NF‐E2) p45‐related factor 2 (Nrf2) activation raises the importance of deciphering the molecular circuitry at the background of multiple‐discrete and antagonistic yet flexible and contextual pathways. While we primarily focus on wound healing and repair mechanisms that are affected in diabetic foot ulcers (DFUs), we strive to explore the striking similarities and differences in molecular events including inflammation, angiogenesis, and fibrosis during tissue injury and wound persistence that accumulates pro‐inflammatory senescent macrophages, as a means to identify possible targets or cellular mediators to lessen DFU disease burden. In addition, the role of iron in the modulation of Nrf2 response in macrophages is crucial and reviewed here. Targeted approaches, unlike conventional treatments, in DFU management will require the review and re‐assessment of mediators with relevance to other pathological conditions.
Improved depressive symptoms in patients with refractory Gilles de la Tourette syndrome after deep brain stimulation of posteroventral globus pallidus interna
Authors: Liu Aijun , Jiao Yongcheng , Zhang Shaohui , Kong Haibo 
Published: May 2022

AbstractObjectiveDeep brain stimulation (DBS) has been used on drug‐resistant Gilles de la Tourette syndrome (GTS) for more than two decades until now, but the stimulating targets are still under exploration until now. In this study, the authors reported the efficacy of the bilateral posteroventral globus pallidus interna (GPi) DBS on tic severity and neuropsychiatry symptoms of seven individuals with GTS.MethodSeven patients with drug‐resistant GTS were enrolled in this study. The severity of these patients was evaluated with Yale Global Tics Severity Scale (YGTSS), Yale Brown Obsessive Compulsive Scale (YBOCS), Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), and Global Assessment of Functioning Scale (GAF). Bilateral posteroventral GPi were selected as the permanent stimulating targets. Follow‐up period was at least 5 years after surgery in the enrolled patients.ResultsAfter surgery, one patient reported no improvement during the follow‐up period, and a device removal surgery was performed. The other six patients reported minor to significant improvement. The overall YGTSS, YBOCS, HAMA HAMD, and GAF scores of these patients were changed positively after surgery, but only the improvement of the motor tic and HAMD scores had a statistical difference. No surgical complication was reported.ConclusionsBilateral posteroventral GPi DBS could relieve the motor tics and depressive symptoms of the enrolled patients significantly, but the vocal tics and other psychiatric symptoms presented a progression without statistical difference during the follow‐up period. The results of this study suggested that bilateral posteroventral GPi are effective targets for the motor tics in GTS patients, especially with prominent depressive symptoms.
Global, regional, and national burden of cancers attributable to tobacco smoking in 204 countries and territories, 1990–2019
Authors: Safiri Saeid , Nejadghaderi Seyed Aria , Abdollahi Morteza , Carson‐Chahhoud Kristin , Kaufman Jay S. , Bragazzi Nicola Luigi , Moradi‐Lakeh Maziar , Mansournia Mohammad Ali , Sullman Mark J. M. , Almasi‐Hashiani Amir , Taghizadieh Ali , Collins Gary S. , Kolahi Ali‐Asghar 
Published: May 2022

AbstractBackgroundCancers are leading causes of mortality and morbidity, with smoking being recognized as a significant risk factor for many types of cancer. We aimed to report the cancer burden attributable to tobacco smoking by sex, age, socio‐demographic index (SDI), and cancer type in 204 countries and territories from 1990 to 2019.MethodsThe burden of cancers attributable to smoking was reported between 1990 and 2019, based upon the Comparative Risk Assessment approach used in the Global Burden of Disease (GBD) study 2019.ResultsGlobally, in 2019 there were an estimated 2.5 million cancer‐related deaths (95% UI: 2.3 to 2.7) and 56.4 million DALYs (51.3 to 61.7) attributable to smoking. The global age‐standardized death and DALY rates of cancers attributable to smoking per 100,000 decreased by 23.0% (−29.5 to −15.8) and 28.6% (−35.1 to −21.5), respectively, over the period 1990–2019. Central Europe (50.4 [44.4 to 57.6]) and Western Sub‐Saharan Africa (6.7 [5.7 to 8.0]) had the highest and lowest age‐standardized death rates, respectively, for cancers attributable to smoking. In 2019, the age‐standardized DALY rate of cancers attributable to smoking was highest in Greenland (2224.0 [1804.5 to 2678.8]) and lowest in Ethiopia (72.2 [51.2 to 98.0]). Also in 2019, the global number of DALYs was highest in the 65–69 age group and there was a positive association between SDI and the age‐standardized DALY rate.ConclusionsThe results of this study clearly illustrate that renewed efforts are required to increase utilization of evidence‐based smoking cessation support in order to reduce the burden of smoking‐related diseases.