bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Design Thinking
Authors: Ku Bon , Lupton Ellen 
Published: March 2022

A practice-based guide to applying the principles of human-centered design to real-world health challenges; updated and expanded with post–COVID-19 innovations.
This book offers a practice-based guide to applying the principles of human-centered design to real-world health challenges that range from drug packaging to breast cancer detection. Written by pioneers in the field—Bon Ku, a physician leader in innovative health design, and Ellen Lupton, an award-winning graphic designer—the book outlines the fundamentals of design thinking and highlights important products, prototypes, and research in health design. This revised and expanded edition describes innovations developed in response to the COVID-19 crisis, including an intensive care unit in a shipping container, a rolling cart with intubation equipment, and a mask brace that gives a surgical mask a tighter seal.
The book explores the special overlap of health care and the creative process, describing the development of such products and services as a credit card–sized device that allows patients to generate their own electrocardiograms; a mask designed to be worn with a hijab; improved emergency room signage; and a map of racial disparities and COVID-19. It will be an essential volume for health care providers, educators, patients, and designers who seek to create better experiences and improved health outcomes for individuals and communities.
Prevalence of Antibiotic Resistant Gram Negative Bacteria in the Street Vended Foods of Bangladesh: An Overview
Authors: Alim Sharmin Rumi , Smritee Lubna Jahan , Konok Ahadul Hassan Bhuiyan , Sadeque Antora , Saurab Shahriar Ahmed , Sarker Shashwata , Sarwar Sneha 
Published: March 2022

Background: Street vended foods contaminated with antibiotic resistant bacteria poses a great public health concern in developing countries like Bangladesh as foodborne diseases caused by such bacteria are difficult and sometimes impossible to treat. The aim of this review is to investigate the present scenario of the antibiotic resistance status of five selected Gram negative bacteria isolated from a variety of street vended foods of Bangladesh.
Methodology: A methodical literature search was performed to identify relevant studies on Google Scholar, Science Direct and Research Gate using suitable keywords arranged in different manners to produce a meaningful search string. Weighted mean resistance was calculated to evaluate the resistance status from 20 studies selected through the PRISMA procedure.
Results: Escherichia coli, Klebsiella spp., Salmonella spp., Pseudomonas spp. and Vibrio spp. showed relatively low resistance towards imipenem and gentamicin, whereas the antibiotics of penicillins and macrolides classes listed in this review were mostly ineffective. Relatively high resistance was found against tetracycline, vancomycin, and rifampicin.
Conclusion: A considerable number of bacterial isolates present in the SVF are resistant to most of the commonly used antibiotics. Therefore, there is an urgent need for public awareness along with a robust national action plan to combat antibiotic resistance, before the situation worsens.
Gordonibacter
Authors: Selma María V. , Beltrán David , Cortés‐Martín Adrián , García‐Villalba Rocío , Tomás‐Barberán Francisco A. , Espín Juan C. 
Published: March 2022

Abstract

Gor.do.ni.bac'ter. N.L. masc. n.
bacter
, a rod; N.L. masc. n.
Gordonibacter
, a rod named after Jeffrey I. Gordon, the Dr. Robert J. Glaser Distinguished University Professor and Director of the Center for Genome Sciences at Washington University School of Medicine, St. Louis, MO, USA; N.L. masc. n.
bacter
a rod; N.L. masc. n.
Gordonibacter
a rod named after Jeffrey I. Gordon.

Actinomycetota / Coriobacteriia / Eggerthellales / Eggerthellaceae / Gordonibacter

The genus
Gordonibacter
accommodates bacteria species that are part of the human gut microbiota and have the ability to metabolize dietary polyphenols such as ellagitannins into bioactive metabolites known as urolithins. Cells of this genus are Gram‐positive, obligatorily anaerobic, motile, non‐spore‐forming, and short‐rod shaped. Often, one cell end appears conical in shape with a pronounced apex ending and with subpolar flagellum insertion. Cells are oxidase‐negative, catalase‐positive, and arginine dihydrolase‐positive, and nitrate is not reduced. They are mesophilic. Growth is generally slow and can be enhanced by the supplementation of the basal medium with 1% arginine hydrochloride (w/v). The major respiratory lipoquinone present is menaquinone 6. Cellular fatty acids consist mainly (70–90%) of saturated fatty acids (predominantly C
14
, C
15
, and C
16
) and monounsaturated fatty acids (mainly C
18:1
ω9
c
). The major polar lipids are phosphatidylglycerol, diphosphatidylglycerol, and four to six glycolipids.

DNA G + C content (mol%)
: 65.1–66.4. The known habitat is the human intestine.

Type species
:
Gordonibacter pamelaeae
Würdemann et al. 2009
VP
.
Polymer Electrode Materials for Lithium‐Ion Batteries
Authors: Du Wanrong , Du Xianfeng , Ma Mingbo , Huang Shan , Sun Xiaofei , Xiong Lilong 
Published: March 2022

AbstractPolymer electrode materials (PEMs) have become a hot research topic for lithium‐ion batteries (LIBs) owing to their high energy density, tunable structure, and flexibility. They are regarded as a category of promising alternatives to conventional inorganic materials because of their abundant and green resources. Currently, conducting polymers, carbonyl polymers, radical polymers, sulfide polymers, and imine polymers as five kinds of PEMs are studied extensively. This review introduces the latest research progress of PEMs for LIBs from the perspectives of molecular structure, redox mechanism, and electrochemical performance. The synthesis mechanisms and methods are outlined to guide the future design of PEMs. However, the practical application of PEMs is limited by their insufficient conductivity, structural instability, and high solubility. Aiming at these obstacles, reasonable optimization strategies are discussed, including the modification of molecular structure, the control of micromorphology, and the composite of carbon materials. Finally, the development trends and prospects of PEMs are put forward.
Ternary‐Assisted Sequential Solution Deposition Enables Efficient All‐Polymer Solar Cells with Tailored Vertical‐Phase Distribution
Authors: Cui Feng‐Zhe , Chen Zhi‐Hao , Qiao Jia‐Wei , Wang Tong , Lu Guang‐Hao , Yin Hang , Hao Xiao‐Tao 
Published: March 2022

AbstractAll‐polymer solar cells (all‐PSCs) have received attention in recent years for their desirable properties in power conversion efficiency and long‐term operational stability. However, it is still a big challenge to acquire an “ideal” vertical‐phase distribution of polymer/polymer blends due to the non‐ideal molecular conformations and mixing behaviors. Herein, a ternary‐assisted sequential solution deposition (SSD) strategy is adopted to regulate the vertical compositional profile of all‐PSCs. A favorable acceptor(donor)‐enriched phase near the cathode(anode) can be obtained by a ternary‐assisted SSD strategy. With such a compositional profile, the exciton yield and carrier density can be enhanced by the vertical component gradient. Remarkably, the non‐geminate recombination is suppressed with an improved exciton diffusion length (15.36 nm) that delivers an outstanding power conversion efficiency over 16% of the ternary PM6/PY‐IT:PDI‐2T SSD devices. This work demonstrates the success of ternary‐assisted SSD strategy in reorganizing the vertical‐phase distribution, which provides a feasible route for a potential ternary device construction toward efficient all‐polymer photovoltaics.
Boosting Tumor Immunotherapy by Bioactive Nanoparticles via Ca2+ Interference Mediated TME Reprogramming and Specific PD‐L1 Depletion
Authors: An Jingyi , Liu Mengyuan , Zhao Ling , Lu Wenxin , Wu Sixuan , Zhang Kaixiang , Liu Junjie , Zhang Zhenzhong , Shi Jinjin 
Published: March 2022

AbstractThe clinical outcomes of programmed cell death protein‐1 (PD‐1)/programmed death ligand‐1 (PD‐L1) blockade are usually limited by the multiple immune evasion mechanism of the tumor, as well as the immune storm caused by “off‐target” effects of the PD‐1/PD‐L1 antibody. Here, a previously unknown strategy is proposed to synergize the “Ca2+ interference” mediated M2‐like tumor‐associated macrophages (TAM) re‐education and Ca2+‐activating locally PD‐L1 depletion for immunotherapy. The authors discover that calcium‐containing nanoparticles can induce significant “Ca2+ interference” effect and simultaneously reset TAM toward the M1 phenotype through activation of multiple inflammation‐related signaling pathways, as well as NLRP3 inflammasomes, and promoting in situ tumor‐associated antigen release. In addition, a circular aptamer‐DNAzyme conjugate (cAD) is designed with a tumor‐targeting ability and its catalytic shear activity can be specifically activated by Ca2+, which reduces potential autoimmune‐like disorders of PD‐L1 antibody. By simply integrating the ultra‐high pH‐sensitive calcium peroxide nanoparticles with cAD into one nanosystem, it is demonstrated that the nanosystem not only arrest primary tumor progression and lung metastasis but also provides a long‐term immunological memory, which can protect against tumor rechallenge. Therefore, this work provides an attractive strategy for boosting tumor immunotherapy.
Nanoscale Faceting and Ligand Shell Structure Dominate the Self‐Assembly of Nonpolar Nanoparticles into Superlattices
Authors: Bo Arixin , Liu Yawei , Kuttich Björn , Kraus Tobias , Widmer‐Cooper Asaph , de Jonge Niels 
Published: March 2022

AbstractSelf‐assembly of nanoscale structures at liquid–solid interfaces occurs in a broad range of industrial processes and is found in various phenomena in nature. Conventional theory assumes spherical particles and homogeneous surfaces, but that model is oversimplified, and nanoscale in situ observations are needed for a more complete understanding. Liquid‐phase scanning transmission electron microscopy (LP‐STEM) is used to examine the interactions that direct the self‐assembly of superlattices formed by gold nanoparticles (AuNPs) in nonpolar liquids. Varying the molecular coating of the substrate modulates short‐range attraction and leads to switching between a range of different geometric structures, including hexagonal close‐packed (hcp), simple hexagonal (sh), dodecahedral quasi‐crystal (dqc), and body‐centered cubic (bcc) lattices, as well as random distributions. Langevin dynamics simulations explain the experimental results in terms of the interplay between nanoparticle faceting, ligand shell structure, and substrate–NP interactions.
Are Redox‐Active Organic Small Molecules Applicable for High‐Voltage (>4 V) Lithium‐Ion Battery Cathodes?
Authors: Katsuyama Yuto , Kobayashi Hiroaki , Iwase Kazuyuki , Gambe Yoshiyuki , Honma Itaru 
Published: March 2022

AbstractWhile organic batteries have attracted great attention due to their high theoretical capacities, high‐voltage organic active materials (> 4 V vs Li/Li+) remain unexplored. Here, density functional theory calculations are combined with cyclic voltammetry measurements to investigate the electrochemistry of croconic acid (CA) for use as a lithium‐ion battery cathode material in both dimethyl sulfoxide and γ‐butyrolactone (GBL) electrolytes. DFT calculations demonstrate that CA dilitium salt (CA–Li2) has two enolate groups that undergo redox reactions above 4.0 V and a material‐level theoretical energy density of 1949 Wh kg–1 for storing four lithium ions in GBL—exceeding the value of both conventional inorganic and known organic cathode materials. Cyclic‐voltammetry measurements reveal a highly reversible redox reaction by the enolate group at ≈4 V in both electrolytes. Battery‐performance tests of CA as lithium‐ion battery cathode in GBL show two discharge voltage plateaus at 3.9 and 3.1 V, and a discharge capacity of 102.2 mAh g–1 with no capacity loss after five cycles. With the higher discharge voltages compared to the known, state‐of‐the‐art organic small molecules, CA promises to be a prime cathode‐material candidate for future high‐energy‐density lithium‐ion organic batteries.
Implementation of a pilot novel objective peer comparison evaluation system in an emergency medicine residency program
Authors: Schreyer Kraftin E. , Healy Megan E. , Repanshek Zachary , Satz Wayne A. , Ufberg Jacob W. 
Published: March 2022

AbstractObjectivesEmergency medicine (EM) residents are currently evaluated via The Milestones, which have been shown to be imperfect and subjective. There is also a need for residents to achieve competency in patient safety and quality improvement processes, which can be accomplished through provision of peer comparison metrics. This pilot study aimed to evaluate the implementation of an objective peer comparison system for metrics that quantified aspects of quality and safety, efficiency and throughput, and utilization.MethodsThis pilot study took place at an academic, tertiary care center with a 3‐year residency and 14 residents per postgraduate year (PGY) class. Metrics were compared within each PGY class using Wilcoxon signed‐rank and rank‐order analyses.ResultsSignificant changes were seen in the majority of the metrics for all PGY classes. PGY3s accounted for the significant change in EKG and X‐ray reads, while PGY1s and PGY2s accounted for the significant change in disposition to final note share. Physician evaluation to disposition decision was the only metric that did not reach significance in any class.ConclusionsThese preliminary data suggest that providing objective metrics is possible. Peer comparison metrics could provide an effective objective addition to the milestone evaluation system currently in use.
Dismutation of Tricyanoboryllead Compounds: The Homoleptic Tetrakis(tricyanoboryl)plumbate Tetraanion
Authors: Häring Mathias , Kerpen Christoph , Ribbeck Tatjana , Hennig Philipp T. , Bertermann Rüdiger , Ignat'ev Nikolai V. , Finze Maik 
Published: March 2022

AbstractA series of unprecedently air‐stable (tricyanoboryl)plumbate anions was obtained by the reaction of the boron‐centered nucleophile B(CN)32− with triorganyllead halides. Salts of the anions [R3PbB(CN)3]− (R=Ph, Et) were isolated and found to be stable in air at room temperature. In the case of Me3PbHal (Hal=Cl, Br), a mixture of the anions [Me4−nPb{B(CN)3}n]n− (n=1, 2) was obtained. The [Et3PbB(CN)3]− ion undergoes stepwise dismutation in aqueous solution to yield the plumbate anions [Et4−nPb{B(CN)3}n]n− (n=1–4) and PbEt4 as by‐product. The reaction rate increases with decreasing pH value of the aqueous solution or by bubbling O2 through the reaction mixture. Adjustment of the conditions allowed the selective formation and isolation of salts of all anions of the series [Et4−nPb{B(CN)3}n]n− (n=2–4) including the homoleptic tetraanion [Pb{B(CN)3}4]4−.
Anchored Palladium Complex‐Generated Clusters on Zirconia: Efficiency in Reductive N‐Alkylation of Amines with Carbonyl Compounds under Hydrogen Atmosphere
Authors: Zhang Zhenzhong , Ikeda Takuya , Murayama Haruno , Honma Tetsuo , Tokunaga Makoto , Motoyama Yukihiro 
Published: March 2022

AbstractCarbon‐nitrogen bond formation is an important method on both laboratory and industrial scales because it realizes the production of valuable pharmaceuticals, agrochemicals, and fine chemicals. Direct reductive N‐alkylation of amines with carbonyl compounds via intermediary imine compounds, especially under catalytic hydrogenation conditions, is one of the most convenient, economical, and environmentally friendly methods for this process. Here we report a novel palladium species on zirconia having specific activity towards hydrogenation of imines but other carbonyl groups remaining intact. The present catalytic property offers a practical synthetic method of functionalized secondary amines by reductive N‐alkylation under mild conditions with high atom‐efficiency. Mechanistic studies revealed that the catalytically active species is the palladium cluster, which is generated in situ from molecular palladium complexes on the support by exposure to atmospheric hydrogen. These fundamental findings are expected to progress in developing novel cluster catalysts for chemical processes directed towards a sustainable society.
Designing Self‐Adaptive Donor‐Switch‐Acceptor Systems for Molecular Opto‐Electronic Conversion Based on Dimethyldihydropyrene/Cyclophanediene
Authors: Jiao Fangfang , Wei Mingzhi , Leng Jiancai , Cui Min , Liu Ziyu , Hu Wei , Zhang Yujin 
Published: March 2022

AbstractThe introduction of a self‐adaptive molecular switch is an appealing strategy to achieve complete charge separation (CS) in donor‐acceptor (D‐A) systems. Here, we designed donor‐switch‐acceptor (D‐S‐A) systems using a platinum(II) terpyridyl complex as the acceptor, dimethyldihydropyrene/cyclophanediene (DHP/CPD) as the bridge, and methoxybenzene, thieno[3,2‐b]thiophene, 2,2′‐bifuran, and 4,8‐dimethoxybenzo[1,2‐b:4,5‐b′]difuran as donors, respectively. We then systematically studied the whole opto‐electronic conversion process of the donor‐DHP/CPD‐acceptor (D‐DHP/CPD‐A) systems based on time‐dependent density functional theory, time‐dependent ultrafast electron evolution, and electron transport property calculations. We first found that the substitution of −CH3by −H and −CN groups in DHP/CPD can enlarge the range of the adsorption wavenumber in opto‐electric conversion. Then the light absorption induces the cationization of DHP switch, largely accelerating the forth‐isomerization to CPD form. Once the D‐CPD‐A molecule is formed, the poor conjugation can realize the complete CS state by inhibiting the radiative and nonradiative charge recombinations. Finally, the repeatable and complete CS can be achieved through the automatic back‐isomerization of CPD to DHP. The present work provides valuable insights into design of D‐S‐A systems for practical utilization of molecule‐based solar harvesting.
Syngas Production by Dry Methane Reforming over Alumina‐Supported Noble Metals and Kinetic Studies
Authors: Karemore Ashvin L. , Sinha Renu , Chugh Parivesh , Vaidya Prakash D. 
Published: March 2022

AbstractDry reforming of methane (DRM) provides valuable syngas from two greenhouse gases, CH4 and CO2. Three alumina‐supported noble metals, Ru, Pt, and Pd, were used as catalysts for the DRM process. Using CO2/CH4 mixtures in the range of 0.5–2 mol mol−1, catalyst performance was assessed in an integral fixed‐bed reactor between 773 and 1073 K. All catalysts were stable for at least 10 h. The DRM kinetics was studied in a differential reactor in the range of 848–898 K, using the power law model. The apparent activation energy values for the consumption of CH4 (86, 89, and 95 kJ mol−1) and CO2 (84, 86, and 91 kJ mol−1) over Ru/Al2O3, Pt/Al2O3, and Pd/Al2O3 as catalysts were found. Several kinetic models of the Langmuir‐Hinshelwood type were considered. A pathway with slow surface reaction between CH4 and CO2 chemisorbed on different types of active sites was found to be most suited to describe the kinetic data.
Material Properties in Cake Filtration – Discrete Element Simulation of Compression‐Permeability Cells
Authors: Friedrich Tiaan , Kuhn Michael , Nasato Daniel Schiochet , Briesen Heiko 
Published: March 2022

AbstractThis simulation study investigates the impact of material properties on the behavior of compressible filter cakes. A compression‐permeability (CP) cell is used as a standard experimental technique for characterizing compressible cakes. It contains a bidisperse particle packing simulated by the discrete element method. Using this setup, a set of crucial material properties is varied and their influence on the macroscopic compression behavior as described by established fitting equations is studied. Sobol's sensitivity analysis is performed, and the results indicate that Young's modulus, the coefficient of sliding friction, and the surface energy density have the strongest impact on cake solidity and compressibility.
Biomechanical modeling of novel high expansion auxetic skin grafts
Authors: Gupta Shubham , Gupta Vivek , Chanda Arnab 
Published: March 2022

AbstractOver 20 million burn injuries are reported every year, with severe cases requiring skin grafting. Traditionally, split thickness skin grafts are prepared by excising a small portion of healthy skin and its incision patterning using a suitable meshing device, which allows the graft to be expanded beyond its capacity. To date, the maximum expansion achieved through skin grafting has been reported to be less than three times, which is not sufficient for covering large burn sites with limited donor site skin. In this work, we have attempted to study skin graft expansion potential with novel auxetic patterns, which are known to exhibit negative Poisson's effect. Two‐layer skin graft models were developed using eight different auxetic incision patterns, and subjected to uniaxial and biaxial tensile strains. The Poisson's ratio, meshing ratio, and induced stresses were characterized for all graft models. The numerical results indicated expansion potentials greater than that of traditional skin grafts across all loads. Extremely high expansions (i.e., >30 times) were estimated for the I‐Shaped Re‐entrant and Rotating Triangles shaped auxetic models without rupture. Such pioneering findings are anticipated to initiate ground‐breaking advances towards skin graft research and improved outcomes in burn surgeries.
Leveraging 5G technology for robotic surgery and cancer care
Authors: Pandav Krunal , Te Austen G. , Tomer Nir , Nair Sujit S. , Tewari Ashutosh K. 
Published: March 2022

AbstractBackgroundThe field of robotic surgery has seen significant advancements in the past few years and it has been adopted in many large hospitals in the United States and worldwide as a standard for various procedures in recent years. However, the location of many hospitals in urban areas and a lack of surgical expertise in the rural areas could lead to increased travel time and treatment delays for patients in need of robotic surgical management, including cancer patients. The fifth generation (5G) networks have been deployed by various telecom companies in multiple countries worldwide. Our aim is to update the readers about the novel technology and the current scenario of surgical procedures performed using 5G technology. In this article, we also discuss how the technology could aid cancer patients requiring surgical management, the future perspectives, the potential challenges, and the limitations, which would need to overcome prior to widespread real‐life use of the technology for cancer care.Recent findingsThe expansion of 5G technology has enabled some countries to conduct remote surgical procedures, tele‐mentored and real‐time interactive procedures on animal models, cadavers, and humans, demonstrating that 5G networks could offer a potential solution to previously experienced latency and reliability hurdles during the remote surgeries performed in the 2000s.ConclusionNew technological advancements could serve as a ground for emerging novel therapeutic applications. While limitations and challenges related to the 5G infrastructure, cost, compatibility, and security exist; researching to overcome the limitations and comprehend the potential benefits of integrating the technology into practice would be imminent before widespread clinical use. Remote and tele‐mentored 5G‐powered procedures could offer a new tool in improving the care of patients requiring robotic surgical management such as prostate cancer patients.