bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful management of a bleeding complication during transaxillary transcatheter aortic-valve implantation: a case report
Authors: Lauten Philipp , El-Garhy Mohamed , Al-Jassem Mahmoud , Lapp Harald 
Published: July 2022

Abstract

Background
The axillary artery is an alternative access route for transcatheter aortic-valve implantation (TAVI) in patients who have unfavourable femoral arteries as well as comorbidities which preclude surgery. Transaxillary TAVI (TAx-TAVI), with a complete non-transfemoral approach, is a feasible and safe alternative even if complications like vascular closure device failure with bleeding occurs.

Case summary
We describe here a simplified non-transfemoral TAx-TAVI approach in a 71-year-old patient with pulmonary oedema due to severe symptomatic aortic stenosis with a prohibitively high surgical risk (Society of Thoracic Surgeons Mortality 11.9%) and extensive peripheral artery disease that rendered the femoral arteries unsuitable for access. Importantly, this strategy also allows for successful management of bleeding events, particularly those associated with vascular closure device failure, by the use of a new covered stent device. The patient was discharged on Day 6 after admission in stable conditions. In short-term follow-up (30 days), he is asymptomatic with normal left-ventricular function.

Discussion
The TAx-TAVI is a promising alternative to transfemoral TAVI approach. Patient safety, even during bleeding complications, can be guaranteed with appropriate preparation.
Do direct payments efficiently support incomes of small and large farms?
Authors: Ciliberti Stefano , Severini Simone , Ranalli Maria Giovanna , Biagini Luigi , Frascarelli Angelo 
Published: July 2022

AbstractThis paper assesses how efficiently Common Agricultural Policy direct payments enhance farm incomes by applying a quantile continuous treatment effect model on the Italian Farm Accountancy Data Network sample. Adding to previous analyses, we show that income responses to direct payments are higher in large farms rather than in small farms and lower in farms benefiting from larger levels of support. This suggests that direct payments are not very efficient in supporting incomes of small farms and reducing the disparity existing within the farm population. Furthermore, results suggest that there is scope to reduce the amount of payments provided to highly supported farms.
Latent class trajectories of socioeconomic position over four time points and mortality: the Uppsala Birth Cohort Study
Authors: Hossin Muhammad Zakir , Heshmati Amy , Koupil Ilona , Goodman Anna , Mishra Gita D 
Published: July 2022

Abstract

Background
The study assessed socioeconomic position (SEP) over four time points and employed a latent class analysis (LCA) to explore the associations between longitudinal SEP trajectories and late-life mortality.

Methods
We analyzed a cohort of 11 336 members born at the Uppsala University Hospital, Sweden during 1915–29 and followed up for mortality during 1980–2008. SEP was measured at birth, age 10, mid-adulthood and late adulthood. LCA was used to identify SEP trajectories, which were linked to all-cause and cause-specific mortality through Cox proportional hazard regression models.

Results
The age and birth cohort adjusted hazard ratio (HR) of all-cause mortality among the upwardly mobile from middle vs. stable low SEP was 28% lower in men [HR: 0.72; 95% confidence interval (95% CI): 0.65, 0.81] and 30% lower in women (HR: 0.70; 95% CI: 0.62, 0.78). The corresponding HR of cardiovascular mortality was 30% lower in men (HR: 0.70; 95% CI: 0.60, 0.82) and 31% lower in women (HR: 0.69; 95% CI: 0.58, 0.83). Upward mobility was also associated with decreased HR of mortality from respiratory diseases and injuries among men and from cancer, respiratory diseases, injuries and mental disorders among women. The upwardly mobile were similar to the stable high group in terms of their HRs of mortality from all-causes and cardiovascular, cancer and mental diseases.

Conclusions
Upward mobility appeared to be protective of mortality from a wide range of causes. Interventions aiming to prevent deaths can benefit from creating optimal conditions earlier in the life course, letting disadvantaged children maximize their socioeconomic and health potentials.
Burden of bacterial bloodstream infections and recent advances for diagnosis
Authors: Costa Susana P , Carvalho Carla M 
Published: July 2022

Abstract
Bloodstream infections (BSIs) and subsequent organ dysfunction (sepsis and septic shock) are conditions that rank among the top reasons for human mortality and have a great impact on healthcare systems. Their treatment mainly relies on the administration of broad-spectrum antimicrobials since the standard blood culture-based diagnostic methods remain time-consuming for the pathogen's identification. Consequently, the routine use of these antibiotics may lead to downstream antimicrobial resistance and failure in treatment outcomes. Recently, significant advances have been made in improving several methodologies for the identification of pathogens directly in whole blood especially regarding specificity and time to detection. Nevertheless, for the widespread implementation of these novel methods in healthcare facilities, further improvements are still needed concerning the sensitivity and cost-effectiveness to allow a faster and more appropriate antimicrobial therapy. This review is focused on the problem of BSIs and sepsis addressing several aspects like their origin, challenges, and causative agents. Also, it highlights current and emerging diagnostics technologies, discussing their strengths and weaknesses.
Sex and Love Among Older Adults in the Digital World: A Scoping Review
Authors: Gewirtz-Meydan Ateret , Opuda Eugenia , Ayalon Liat 
Published: July 2022

AbstractBackground and ObjectivesThe digital world offers opportunities for sex and love and also reflects societal stereotypes regarding sex and love among older adults. The aim of the current review is to look at the ways older adults use digital media for sex and love and also at digital media’s representations of older adults.Research Design and MethodsWe searched for studies published in English that used qualitative and/or quantitative methods, with findings based on empirical data from individuals 55 years of age or older. The following data sets were searched: PubMed, Web of Science, PsycINFO, Cochrane Database of Systematic Reviews, and CINAHL. Bibliographies of all relevant studies were searched. Titles and abstracts were reviewed, and selected articles were extracted independently by 2 reviewers.ResultsA total of 1,819 records were retrieved. After removing duplicates, 1,488 records remained. Of these, 70 records remained for full-text screening, and a final count of 15 records was included for synthesis.Discussion and ImplicationsThe present review highlights major research gaps in the field. Although studies have indeed focused on the online dating scene among this cohort, they have ignored older adults’ sexuality in favor of other aspects (e.g., love and companionship). Representations of this cohort in terms of love and sex are also lacking, and diversity is hardly addressed. Additional research is needed to examine how older adults use digital media for reasons related to love and sex, and how the media mirrors societal stereotypes regarding sex and love among older adults.
Chandler period estimated from frequency domain expression solving the Liouville equation for polar motion
Authors: Li Mingyu , Shen Wenbin 
Published: July 2022

SUMMARYAccurate determination of the Chandler wobble (CW) period (TCW) and quality factor (QCW) is of great significance to our understanding of the Earth's dynamic figure parameters, elasticity, rheology and energy dissipation. TCW and QCW were typically determined in the time domain using the digital filter designed by Wilson; however, we developed an alternative method to estimate TCW in the frequency domain. We adopted the frequency domain expression solving the Liouville equation for polar motion (eq. 3 in the following) rather than the time domain to separate the free-damping CW and excited parts. Next, we substituted various excitation functions derived from the outputs of several general circulation models and selected monthly gravity models into the above frequency domain expression; hence we estimate TCW. The preferred TCW value using this method and the least difference combination mgm90 model is 430.4 ± 2.0 mean solar days. Comparing with previous studies within the error range, our results provide an independent way of estimating TCW.
Cultural context in New Zealand: incorporating kaupapa Māori values in clinical research and practice
Authors: Rolleston Anna , Miskelly Philippa , McDonald Marama , Wiles Janine , Poppe Katrina , Doughty Rob 
Published: July 2022

AbstractWe examined the importance of understanding and incorporating cultural context within Aotearoa/New Zealand when engaging in clinical research and practice. This paper reports on the qualitative findings of a mixed methods study aimed at determining what effect a cardiac risk reduction exercise and lifestyle management programme, embedded within a kaupapa Māori methodological approach, had on Māori participants. This methodology saw participants able to redevelop a western model cardiac risk reduction programme by introducing a Māori worldview. Our study revealed how the kaupapa Māori approach empowered participants to examine and evaluate not only their own health and lifestyle choices, but those of family and the wider community. Combining biomedical and kaupapa Māori components into the programme was found to benefit participants’ mental, physical, spiritual and family well-being.
Exercise motives impact on physical activities measured using wearable devices
Authors: Hewitt Barbara , Deranek Kimberly , McLeod Alex , Gudi Arvind 
Published: July 2022

Abstract
Health officials advocate for increased physical activity to address negative health consequences. While previous studies have investigated what motivates different individuals to exercise, the motives were not verified using unbiased measurements. Information and Communication Technologies (ICT), including wearables, are essential for collecting and sharing data necessary for improving health initiatives. The purpose of this study was to use objective measures collected by wearable devices (Fitbit) to track activity and explore whether specific exercise motives impact participants’ physical activities. Ninety-six college freshmen enrolled in the 90-day study. During orientation, participants completed an Exercise Motives Inventory-2 (EMI-2), and their current physical state was baselined. Partial Least Squares (PLS)—Structural Equation Modeling (SEM) was used to model the relationship between variables. The results revealed a relationship between Interpersonal Motives, Health Motives, and Fitness Motives, and participants’ physical activities. Those striving to facilitate a change in exercise behavior in young adults should leverage activities that align with their motives of interest and consider the use of wearable devices to track physical activity.
What about Females? Urban Female Song Sparrows Elevate Aggressive Signaling Compared to Rural
Authors: Lane Samuel J , Sewall Kendra B 
Published: July 2022

AbstractThe costs and benefits of breeding behaviors are influenced by environmental conditions, and habitat variation can shift the degree to which behaviors are expressed. Novel urban habitats have been shown to differ significantly in disturbances such as noise, light at night, and human presence, as well as resource availability, compared to rural habitats. Perhaps because of these environmental differences, urban males of several species are consistently more aggressive than rural males, raising the hypothesis that greater territorial aggression is beneficial in urban habitats. Though often ignored, female songbirds of many species also perform aggressive territorial behaviors toward conspecifics during the breeding season. For socially monogamous songbirds, this aggression functions to ensure partner fidelity and secure resources for reproduction. Studies of the effects of urbanization on songbird behavior have yet to determine if urban females also express greater territorial aggression. Importantly, energetically demanding behaviors such as territoriality and parental care should constrain one another, leading to behavioral trade-offs during the breeding season. Though territorial aggression and parental care are inversely related in males of several species of songbird, this relationship is understudied in female songbirds, particularly those facing environmental change, such as urbanization. In this study, we compared aggressive signaling and a measure of parental care (maternal nest visitation rates) between female song sparrows (Melospiza melodia), living in urban and rural habitats. We hypothesized that female aggressive signaling would be higher in urban environments compared to rural, and negatively correlated with maternal visitation rates. We found that urban females, like males, expressed increased aggressive signaling compared to rural. However, female aggressive signaling was not related to our measure of maternal care, suggesting females aren't facing a trade-off between these two behaviors. Collectively, our results are consistent with the hypothesis that urban habitats promote territorial aggression in female song sparrows. As urbanization continues to spread, understanding the behavioral changes animals employ in urban environments requires studying individuals of different sexes and age classes, and will help us understand how some species are able to cope with human-induced rapid environmental change.
The Effect of Government Repression on Civil Society: Evidence from Cambodia
Authors: Springman Jeremy , Malesky Edmund , Right Lucy , Wibbels Erik 
Published: July 2022

Abstract
Nongovernmental organizations (NGOs) are a core component of a robust civil society and operate in a wide variety of sectors, ranging from service delivery to political advocacy. However, research has yet to systematically investigate whether the impact of government repression varies across NGO activities. We hypothesize that advocacy NGOs are more affected by repression than those in service delivery. Surveying 176 employees from 106 NGOs in Cambodia, we employ a conjoint experiment to examine how the level of repression affects a task crucial to NGOs’ survival: obtaining funding via grant applications. We find that while increases in the severity of repression appear to have a stronger deterrent effect for advocacy NGOs, repression has a large deterrent effect on service NGOs as well. Interviews and text analysis of open-ended questions suggest that local officials target both advocacy and service delivery NGOs, but for different reasons. Our findings speak to the spread of authoritarianism and the challenges NGOs face in countries with closing civic spaces.
Identifying patient-level risk factors associated with non-β-lactam resistance outcomes in invasive MRSA infections in the United States using chain graphs
Authors: Love William J , Wang C Annie , Lanzas Cristina 
Published: July 2022

AbstractBackgroundMRSA is one of the most common causes of hospital- and community-acquired infections. MRSA is resistant to many antibiotics, including β-lactam antibiotics, fluoroquinolones, lincosamides, macrolides, aminoglycosides, tetracyclines and chloramphenicol.ObjectivesTo identify patient-level characteristics that may be associated with phenotype variations and that may help improve prescribing practice and antimicrobial stewardship.MethodsChain graphs for resistance phenotypes were learned from invasive MRSA surveillance data collected by the CDC as part of the Emerging Infections Program to identify patient level risk factors for individual resistance outcomes reported as MIC while accounting for the correlations among the resistance traits. These chain graphs are multilevel probabilistic graphical models (PGMs) that can be used to quantify and visualize the complex associations among multiple resistance outcomes and their explanatory variables.ResultsSome phenotypic resistances had low connectivity to other outcomes or predictors (e.g. tetracycline, vancomycin, doxycycline and rifampicin). Only levofloxacin susceptibility was associated with healthcare-associated infections. Blood culture was the most common predictor of MIC. Patients with positive blood culture had significantly increased MIC of chloramphenicol, erythromycin, gentamicin, lincomycin and mupirocin, and decreased daptomycin and rifampicin MICs. Some regional variations were also observed.ConclusionsThe differences in resistance phenotypes between patients with previous healthcare use or positive blood cultures, or from different states, may be useful to inform first-choice antibiotics to treat clinical MRSA cases. Additionally, we demonstrated multilevel PGMs are useful to quantify and visualize interactions among multiple resistance outcomes and their explanatory variables.
Pricing Retrovir: Wellcome PLC and the Role of Pharmaceutical Companies in the Global AIDS Crisis, 1986 to 1991
Authors: Kanazawa Reiko 
Published: July 2022

Abstract
In spring 1987, British pharmaceutical company Wellcome PLC released azidothymidine (AZT) sold under trade name Retrovir, the first successful treatment for AIDS. In the context of a global public health emergency and with no competing products, Wellcome invested heavily in upfront costs to bring Retrovir to market, reflected in the original launch price of $188 (US dollars), applied to all other markets. Retrovir subsequently faced backlash in the United States for its high cost and Wellcome’s profits became a target of debates about prescription drugs in the American healthcare system. As a result, the company agreed to two price reductions within the first two years of market release. Events in the US had global impact, discouraging the company from providing AZT via commercial channels in African countries. Drawing from new archival material, this article explores how Retrovir’s pricing reflected the uncertainties of the global AIDS crisis as well as the unique risks Wellcome faced as a foreign company in its most important market of the US. It argues that, contrary to critical opinion, Wellcome’s pricing of Retrovir did reflect an underlying principle regarding the appropriate role of for-profit research-intensive pharmaceutical companies during an unprecedented pandemic.
Comparison of modern periacetabular osteotomy for hip dysplasia with total hip arthroplasty for hip osteoarthritis—10-year outcomes are comparable in young adult patients
Authors: Parilla Frank W , Freiman Serena , Pashos Gail E , Thapa Susan , Clohisy John C 
Published: July 2022

ABSTRACT
Young adult patients with symptomatic acetabular dysplasia and marginal secondary osteoarthritis can be faced with the decision to either undergo periacetabular osteotomy (PAO) to relieve symptoms and slow osteoarthritis progression or wait until progression to more advanced disease and undergo total hip arthroplasty (THA). The decision can be difficult, and contemporary literature to guide these decisions is sparse. Therefore, we retrospectively assessed complication rate, survivorship and patient-reported clinical outcomes [modified Harris Hip score (mHHS), UCLA Activity score] in two, consecutive cohorts of patients aged 18–40 years that underwent either PAO for symptomatic acetabular dysplasia (mean age 28.9 years) or THA for advanced secondary osteoarthritis (32.5 years). PAO patients were followed for a mean of 10.5 years (8–19) and THA patients for 11.9 (8–17)  years. Between PAO and THA groups, there were no differences in overall complication rate (4.7% versus 4.7%), non-revision reoperation rate (5.9% versus 2.3%, P = 0.37) or end-revision rate [7 (8.2%) PAOs converted to THA at mean 10.8 years versus 3 (7.0%) THAs revised at 6.2 years, P = 0.80]. Latest scores remained significantly improved from baseline in both the PAO (mHHS 86.1 versus 63.3, P &lt; 0.001; UCLA 7.5 versus 6.9, P &lt; 0.05) and THA (mHHS 82.6 versus 48.4, P &lt; 0.001; UCLA 7.2 versus 4.6, P &lt; 0.001) cohorts. Final scores were similar between groups (mHHS 86.1 versus 82.6, P = 0.46; UCLA 7.5 versus 7.2, P = 0.37). Clinical success [mHHS minimal clinically important difference (8) OR PASS (&gt;70) at latest follow-up without end-revision] was achieved in 81.2% of PAO hips and 83.7% of THA hips (P = 0.72).
Phytochemicals from medicinal plants from African forests with potentials in rheumatoid arthritis management
Authors: Aloke Chinyere , Ohanenye Ikenna C , Aja Patrick M , Ejike Chukwunonso E C C 
Published: July 2022

Abstract

Objectives
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation, pain, and cartilage and bone damage. There is currently no cure for RA. It is however managed using nonsteroidal anti-inflammatory drugs, corticosteroids and disease-modifying anti-rheumatic drugs, often with severe side effects. Hidden within Africa’s lush vegetation are plants with diverse medicinal properties including anti-RA potentials. This paper reviews the scientific literature for medicinal plants, growing in Africa, with reported anti-RA activities and identifies the most abundant phytochemicals deserving research attention. A search of relevant published scientific literature, using the major search engines, such as Pubmed/Medline, Scopus, Google Scholar, etc. was conducted to identify medicinal plants, growing in Africa, with anti-RA potentials.

Key findings
Twenty plants belonging to 17 families were identified. The plants are rich in phytochemicals, predominantly quercetin, rutin, catechin, kaempferol, etc., known to affect some pathways relevant in RA initiation and progression, and therefore useful in its management.

Summary
Targeted research is needed to unlock the potentials of medicinal plants by developing easy-to-use technologies for preparing medicines from them. Research attention should focus on how best to exploit the major phytochemicals identified in this review for the development of anti-RA ‘green pharmaceuticals’.
Comparison of three in vitro keratinocytes-fibroblasts wound healing models commonly used in pharmaceutical research
Authors: Wong Hui Xin , Lee Chin Chiat , Ho Paul Chi-Lui 
Published: July 2022

Abstract

Objectives
Several common wound healing models have been used to evaluate wound healing agents and formulations, namely: conditioned media (CM), transwell co-cultures (TWCC) and co-cultures (CC) in a monolayer. However, no study has been conducted to compare the relevance of these models in the keratinocytes and fibroblasts interaction physiologically. Therefore, this study aimed to compare these models based on cell migration and proliferation, and matrix metalloproteinase (MMP) expression.

Methods
Cell migration was analysed by scratch assay and MMP-7, while cell proliferation was analysed by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay.

Key findings
Increased cell migration was observed in CM and TWCC models, while varied results were obtained in CC. Cell migration was increased due to upregulation of MMP-7 in CM and TWCC models, while it was downregulated in CC, which might have hindered migration of both cells in monolayers.

Conclusions
CM and TWCC are more suitable than CC for wound healing research and for evaluating wound healing agents or formulations, as they can better simulate the layered tissue constructs and paracrine interactions in the physiological environment.