bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ground motion prediction equations as a proxy for medium properties variation due to geothermal resources exploitation
Authors: Convertito Vincenzo , De Matteis Raffaella , Amoroso Ortensia , Capuano Paolo 
Published: July 2022

AbstractSub surface operations for energy production such as gas storage, fluid injection or hydraulic fracking modify the physical properties of the crust, in particular seismic velocity and anelastic attenuation. Continuously measuring these properties may be crucial to monitor the status of the reservoir. Here we propose a not usual use of the empirical ground-motion prediction equations (GMPEs) to monitor large-scale medium properties variations in a reservoir during fluid injection experiments. In practice, peak-ground velocities recorded during field operations are used to update the coefficients of a reference GMPE whose variation can be physically interpreted in terms of anelastic attenuation and seismic velocity. We apply the technique to earthquakes recorded at The Geysers geothermal field in Southern California and events occurred in the St. Gallen (Switzerland) geothermal field. Our results suggest that the GMPEs can be effectively used as a proxy for some reservoir properties variation by using induced earthquakes recorded at relatively dense networks.
Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation
Authors: Sawamura Masanori , Imamura Keiko , Hikawa Rie , Enami Takako , Nagahashi Ayako , Yamakado Hodaka , Ichijo Hidenori , Fujisawa Takao , Yamashita Hirofumi , Minamiyama Sumio , Kaido Misako , Wada Hiromi , Urushitani Makoto , Inoue Haruhisa , Egawa Naohiro , Takahashi Ryosuke 
Published: July 2022

AbstractMutations withinSuperoxide dismutase 1(SOD1) cause amyotrophic lateral sclerosis (ALS), accounting for approximately 20% of familial cases. The pathological feature is a loss of motor neurons with enhanced formation of intracellular misfolded SOD1. HomozygousSOD1-D90Ain familial ALS has been reported to show slow disease progression. Here, we reported a rare case of a slowly progressive ALS patient harboring a novelSOD1homozygous mutationD92G(homD92G). The neuronal cell line overexpressing SOD1-D92G showed a lower ratio of the insoluble/soluble fraction of SOD1 with fine aggregates of the misfolded SOD1 and lower cellular toxicity than those overexpressing SOD1-G93A, a mutation that generally causes rapid disease progression. Next, we analyzed spinal motor neurons derived from induced pluripotent stem cells (iPSC) of a healthy control subject and ALS patients carryingSOD1-homD92Gor heterozygousSOD1-L144FVXmutation. Lower levels of misfolded SOD1 and cell loss were observed in the motor neurons differentiated from patient-derived iPSCs carryingSOD1-homD92Gthan in those carryingSOD1-L144FVX. Taken together, SOD1-homD92G has a lower propensity to aggregate and induce cellular toxicity than SOD1-G93A or SOD1-L144FVX, and these cellular phenotypes could be associated with the clinical course of slowly progressive ALS.
Promising anti-leukemic effect of Zataria multiflora extract in combination with doxorubicin to combat acute lymphoblastic leukemia cells (Nalm-6) (in vitro and in silico)
Authors: Lashkari Mahla , Fatemi Ahmad , Valandani Hajar Mardani , Khalilabadi Roohollah Mirzaee 
Published: July 2022

AbstractOne of the heterogeneous hematologic malignancies of the lymphocyte precursors is ALL. ALL has two incidence peaks that were determined in 2–5 years children and 60 years old adults. Cardiotoxicity of chemotherapeutic drugs is one of important side effects which may occur during or after chemotherapy period. The aim of this study was to evaluate the effect of ZME, Dox, and combinations on Nalm-6 cells. In this vein, the cell viability was assessed by Trypan blue and MTT assay. Evaluation of apoptosis was also analyzed by Annexin-V/PI staining. Moreover, the expression of Bax, Bcl-2, Bcl-xl, hTERT, c-Myc, P53, and P21 genes was detected by Real-Time PCR. Molecular docking as an in-silico method was performed for Bcl-2 and Bcl-xl proteins as well. Our achievements indicated that ZME had dose-dependent effect on Nalm-6 cells and ZME synergistically potentiated Dox effect. The expression of Bax, P53 and P21 genes increased although the expression of Bcl-2 genes decreased when cells treated with ZME/ Dox combination. Molecular docking showed the interactions of carvacrol and thymol in the active cavities of BCL2 and BCL-xl. Regarding to present study, ZME could be utilized as a combinatorial and potential drug for leukemic patients, which is under the treatment by Dox due to reducing the chemotherapy drug doses.
Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis
Authors: Yao Yu-Feng , Chen Zhen-Yu , Luo Tian-Yi , Dou Xiao-Yan , Chen Hai-Bo 
Published: July 2022

AbstractWe aimed to examine whether the efficacy of the risk of poor prognosis in patients with coronary artery disease is jointly affected by total cholesterol and baseline serum albumin in a secondary analysis of previous study. We analyzed the data of 204 patients from October 2014 to October 2017 for newly diagnosed stable CAD. The outcome was major adverse cardiac events (MACE; defined as all cause mortality, non fatal myocardial infarction, and non fatal stroke). The median duration of follow-up was 783 days. Multivariable COX model was performed to revalidate the relationship between the sALB and MACE and interaction tests were conducted to find the effects of total cholesterol on their association. A total of 28 MACE occurred among the 204 participants. The risk of MACE varied by baseline serum albumin and total cholesterol. Specifically, lower serum albumin indicated higher risk of MACE (HR 3.52, 95% CI 1.30–9.54), and a test for interaction between baseline serum albumin and total cholesterol on MACE was significant (P = 0.0005). We suggested that baseline serum albumin and total cholesterol could interactively affect the risk of poor prognosis of patients with coronary artery diseases. Our findings need to be confirmed by further randomized trials.
2450-MHz microwave ablation of liver metastases under 3.0 T wide-bore magnetic resonance guidance: a pilot study
Authors: Xu Kaihao , Li Zhaonan , Liu Yiming , Liu Zaoqu , Wang Chaoyan , Jiao Dechao , Han Xinwei 
Published: July 2022

AbstractTo investigate the feasibility and effectiveness of 3.0 T wide-bore magnetic resonance (MR)-guided microwave ablation (MA) of liver metastases (LM). From October 2018 to May 2020, 39 patients with 63 LM were treated with 3.0 T wide-bore MR-guided 2450-MHz MA therapy. The procedure parameters, technical success, complications, biochemical index changes, local tumor response, local tumor progression (LTP), 12-month disease-free survival (DFS) and 12-month overall survival (OS) were recorded and analyzed. The mean tumor maximum diameter and total procedure time were 3.0 cm and 55.2 min, respectively. Technical success was 100%, but 5 cases (12.8%) had grade-1 complications. Alanine transaminase, aspartate transaminase and total bilirubin showed a slight transient increase on day 3 (P < 0.05) and returned to normal by day 30 (P > 0.05). The complete ablation rates for ≤ 2.5 and > 2.5 cm lesions were 100% and 92.5%, respectively. During the median follow-up of 12.0 months, the LTP rate was 4.8% (3/63), and the 12-month DFS and OS rates were 61.3% and 92.2%, respectively. 3.0 T wide-bore MR-guided MA for LM is a safe and effective approach, especially for small LM.
Application of dry olive residue-based biochar in combination with arbuscular mycorrhizal fungi enhances the microbial status of metal contaminated soils
Authors: Siles José A. , García-Romera Inmaculada , Cajthaml Tomas , Belloc Jorge , Silva-Castro Gloria , Szaková Jirina , Tlustos Pavel , Garcia-Sanchez Mercedes 
Published: July 2022

AbstractBiochar made-up of dry olive residue (DOR), a biomass resulting from the olive oil extraction industry, has been proposed to be used as a reclamation agent for the recovery of metal contaminated soils. The aim of the present study was to investigate whether the soil application of DOR-based biochar alone or in combination with arbuscular mycorrhizal fungi (AMF) leads to an enhancement in the functionality and abundance of microbial communities inhabiting metal contaminated soils. To study that, a greenhouse microcosm experiment was carried out, where the effect of the factors (i) soil application of DOR-based biochar, (ii) biochar pyrolysis temperature (considering the variants 350 and 500 °C), (iii) soil application dose of biochar (2 and 5%), (iv) soil contamination level (slightly, moderately and highly polluted), (v) soil treatment time (30, 60 and 90 days) and (vi) soil inoculation with Funneliformis mosseae (AM fungus) on β-glucosidase and dehydrogenase activities, FA (fatty acid)-based abundance of soil microbial communities, soil glomalin content and AMF root colonization rates of the wheat plants growing in each microcosm were evaluated. Biochar soil amendment did not stimulate enzyme activities but increased microbial abundances. Dehydrogenase activity and microbial abundances were found to be higher in less contaminated soils and at shorter treatment times. Biochar pyrolysis temperature and application dose differently affected enzyme activities, but while the first factor did not have a significant effect on glucosidase and dehydrogenase, a higher biochar dose resulted in boosted microbial abundances. Soil inoculation with F. mosseae favored the proliferation of soil AMF community and increased soil glomalin content as well as rates of AMF root colonization. This factor also interacted with many of the others evaluated to significantly affect soil enzyme activities, microbial abundances and AMF community. Our results indicate that the application of DOR-based biochar along with AMF fungi is an appropriate approach to improve the status of microbial communities in soils with a moderate metal contamination at short-term.
Aerosol effects on the vertical structure of precipitation in East China
Authors: Sun Nan , Fu Yunfei , Zhong Lei , Li Rui 
Published: July 2022

AbstractIn this paper, we examine the aerosol effects on the vertical structure of precipitation in East China by matching GPM DPR (Global Precipitation Measurement Dual-frequency Precipitation Radar) and MERRA-2 (Modern-Era Retrospective analysis for Research and Applications, Versions2) datasets. It was found that the increase of aerosol will obviously increase the precipitation frequency when AOD (Aerosol Optical Depth) ≤ 0.5, but the excessive aerosol suppresses the precipitation frequency when AOD > 0.5 in some regions. The AOD obviously enhances the radar echo intensity of precipitation and has a stronger impact on convective precipitation. The correlation between AOD and rain rate, and that between AOD and STH (storm top height) are different in different regions of East China. The aerosol reduces the mean droplet concentration in most regions except NC (Northeast China). In most cases, aerosol increases the effective radius of precipitation and has a higher impact on convective precipitation.
PI3Kδ activity controls plasticity and discriminates between EMT and stemness based on distinct TGFβ signaling
Authors: Agnetti Jean , Bou Malham Vanessa , Desterke Christophe , Benzoubir Nassima , Peng Juan , Jacques Sophie , Rahmouni Souad , Di Valentin Emanuel , Tan Tuan Zea , Samuel Didier , Thiery Jean Paul , Gassama-Diagne Ama 
Published: July 2022

AbstractThe stem cells involved in formation of the complex human body are epithelial cells that undergo apicobasal polarization and form a hollow lumen. Epithelial plasticity manifests as epithelial to mesenchymal transition (EMT), a process by which epithelial cells switch their polarity and epithelial features to adopt a mesenchymal phenotype. The connection between the EMT program and acquisition of stemness is now supported by a substantial number of reports, although what discriminates these two processes remains largely elusive. In this study, based on 3D organoid culture of hepatocellular carcinoma (HCC)-derived cell lines and AAV8-based protein overexpression in the mouse liver, we show that activity modulation of isoform δ of phosphoinositide 3-kinase (PI3Kδ) controls differentiation and discriminates between stemness and EMT by regulating the transforming growth factor β (TGFβ) signaling. This study provides an important tool to control epithelial cell fate and represents a step forward in understanding the development of aggressive carcinoma.
Mitochondrial surface coating with artificial lipid membrane improves the transfer efficacy
Authors: Nakano Takafumi , Nakamura Yoshihiko , Park Ji-Hyun , Tanaka Masayoshi , Hayakawa Kazuhide 
Published: July 2022

AbstractExtracellular mitochondria are present and act as non-cell-autonomous signals to support energetic homeostasis. While mitochondria allograft is a promising approach in rescuing neurons, glia, and vascular cells in CNS injury and disease, there are profound limitations in cellular uptake of mitochondria together with the efficacy. Here, we modified mitochondria by coating them with cationic DOTAP mixed with DOPE via a modified inverted emulsion method to improve mitochondrial transfer and efficacy. We initially optimized the method using control microbeads and liposomes followed by using mitochondria isolated from intact cerebral cortex of male adult C57BL/6J mice. After the coating process, FACS analysis indicated that approximately 86% of mitochondria were covered by DOTAP/DOPE membrane. Moreover, the artificial membrane-coated mitochondria (AM-mito) shifted the zeta-potential toward positive surface charge, confirming successful coating of isolated mitochondria. Mitochondrial proteins (TOM40, ATP5a, ACADM, HSP60, COX IV) and membrane potentials were well maintained in AM-mito. Importantly, the coating improved mitochondrial internalization and neuroprotection in cultured neurons. Furthermore, intravenous infusion of AM-mito immediately after focal cerebral ischemia-reperfusion amplified cerebroprotection in vivo. Collectively, these findings indicate that mitochondrial surface coating with artificial lipid membrane is feasible and may improve the therapeutic efficacy of mitochondria allograft.
Feature‐based augmentation and classification for tabular data
Authors: Sathianarayanan Balachander , Singh Samant Yogesh Chandra , Conjeepuram Guruprasad Prahalad S. , Hariharan Varshin B. , Manickam Nirmala Devi 
Published: July 2022

AbstractGenerating synthetic samples for a tabular data is a strenuous task. Most of the time, the columns (features) in the dataset may not follow an ideal distribution function. The objective of the proposed algorithm, Histogram Augmentation Technique (HAT), is to generate a dataset whose distribution is similar to that of the original dataset. This augmentation is achieved based on individual columns, where separate algorithms are designed for continuous and discrete columns. Humans also use features of an object for interpretation. When humans make a judgement, they notice prominent features and characterise the perceived object. However, conventional Machine Learning classifiers are designed and trained on the basis of samples. Taking the features as the basis for classification, Feature Importance Classifier (FIC) has been attempted in this work. FIC treats every feature independent of each other, and ranks the features based on its dependence with the classified label. It has been found that the FIC has the highest accuracy and has improved the accuracy by 5.54% on average, when it's compared to other classifiers. The suggested algorithms have been experimented on five datasets and compared with two augmentation algorithms and four state‐of‐the‐art ML classification algorithms.
A novel approach to multi‐objective optimisation of the size and location of an improved hybrid flow controller
Authors: Moradi Behzad , Kargar Abbas , Derakhshandeh Sayed Yaser , Niaki Sayed Ali Nabavi 
Published: July 2022

AbstractTransient stability is one of the major features of power systems operation which can be also considered an objective function in the flexible AC transmission systems (FACTS) allocation problem. This paper introduces a general multi‐level multi‐objective optimisation framework and its application on optimising the size and location of the improved hybrid flow controller (IHFC). IHFC is a new member of the FACTS family whose ability to control power flow and improve power system stability has been investigated. The optimisation problem considers economic and stability‐based objective functions simultaneously, and the allocation problem is formulated as a non‐linear programming (NLP) problem. The New England 39‐bus system has been used as a case study to demonstrate that the proposed framework can provide efficient and economically viable solutions to the allocation problem.
Dynamic data‐driven computation method for the number of waiting passengers and waiting time in the urban rail transit network
Authors: Chen Yanyan , Li Tongfei , Sun Yan , Wu Jianjun , Guo Xin , Liu Di 
Published: July 2022

AbstractExcess passengers gathering on the urban rail transit platform in a short time brings huge security risks to passengers and the daily operation of urban rail transit. However, the real‐time monitoring method of passenger flows, which relies on manual methods, cannot satisfy the requirement of daily operations at the network level anymore. This study proposes a dynamic data‐driven computation and monitoring method for the number of waiting passengers on platforms to recognize the operational risk in real‐time. For waiting passengers on platforms, the waiting time duration before boarding is also calculated based on a first‐come‐first‐service basis. It can be used to provide real‐time information services to passengers and evaluate service quality. Moreover, the proposed methodology relies solely on the AFC data and the train timetable, which makes it easy to implement in the daily operation of any urban rail transit system. Finally, taking the Beijing rail transit network as a case study, the real‐time number of waiting passengers on each platform, and the time duration passengers should wait before boarding are calculated dynamically. Meanwhile, the spatio‐temporal distribution of passengers’ waiting time and waiting passengers are detailly analyzed based on the method of cluster analysis and the complex network theory.
Influence of volume and surface conductivity on the transient surface charge characteristics of DC‐GIL insulator under thermal–electric coupled fields
Authors: Li Xiaolong , Han Songling , Wang Wen , Geng Zhenxin , Lin Xin 
Published: July 2022

AbstractHere, the transient surface charge distribution of a basin‐type insulator is investigated under thermal–electric coupled fields. Horizontally installed ±200 kV direct current gas‐insulated transmission lines (DC‐GIL) are employed, and a 3D geometric model is applied. An improved method is introduced in the transient simulation under coupled fields, which involves simplifying geometric model, decoupling calculation, applying weak form partial differential equation, and simplifying ion transport equation. The influence of volume and surface electric conductivity on the transient surface charge and electric field distribution is discussed. With increasing volume conductivity, the transient charge accumulation is accelerated due to the promotion of conduction through the insulator. With increasing volume conductivity, the polarity of the charge on convex surface changes from negative to positive, while it changes from positive to negative with increasing surface conductivity. This is the consequence of the transition in dominant conduction mechanism. Non‐monotonic variation of charge density is observed attributing to the variation transient field distribution. It can be concluded that the influence of volume and surface conductivity should be focused on when evaluating the insulation characteristics of DC‐GIL insulators, and the thermal gradient should be considered in dealing with the long‐term operating insulators.
Der Return-to-Prozess für die obere Extremität
– ein systematisches Review
Authors: Bäumler Hannah , Griefahn Annika , Zalpour Christoff 
Published: July 2022

Zusammenfassung
Einleitung Verletzungen im Sport sind in jeder Altersklasse unvermeidbar.
Häufig unterscheiden sich durchgeführte Rehabilitationsmethoden
weitreichend und der Zeitpunkt der Bereitschaft für eine
Rückkehr in den Sport kann nicht eindeutig bestimmt werden. Ein
funktionsbasiertes Rehabilitationsmodell in Form des Return-to-Prozesses
könnte den Wiedereinstieg in den Sport, anhand von Testbatterien,
strukturierter gestalten und Aussagen über die
Funktionsfähigkeit der betroffenen Struktur ermöglichen. Bisher
erfolgten in diesem Themenbereich vorwiegend Untersuchungen der unteren
Extremität. Ziel dieser Studie ist es Erweiterungsmerkmale für
den Return-to-Prozess der oberen Extremität darzustellen.
Methode Die Erstellung der systematischen Übersichtsarbeit
orientierte sich an den PRISMA-Guidelines. Für die Literaturrecherche
wurden die Datenbanken Pubmed, Cochrane Library und Web of Science nach
relevanten Studien durchsucht. Anhand der Studienergebnisse wurden die
angewandten Testverfahren zusammengetragen und miteinander verglichen.
Ergebnisse Den Einschlusskriterien entsprachen eine Kohortenstudie, 6
Fallstudien und 7 Expertenmeinungen. Zum aktuellen Zeitpunkt gibt es keine
einheitliche Definition für die Anwendung des Return-to-Prozesses. Der
Begriff Return-to wird häufig auch unabhängig von
Rehabilitationsmaßnahmen verwendet, um den Wiedereinstieg in den Sport
zu beschreiben. Die Organisation innerhalb des Return-to-Prozesses unterscheiden
sich zwischen den Autoren deutlich. Auch die angewandten Testverfahren wiesen
kaum Überschneidungen auf. Die Bereitschaft für die
Rückkehr in den Sport ist nicht einheitlich definiert und wird sowohl
mit Hilfe von Funktionstests als auch Krafttests dargestellt. Für einen
erfolgreichen Return-to-Prozess werden transparente und athletenzentrierte
Entscheidungen im interdisziplinären Team, die Integration des
biopsychosozialen Ansatzes und eine nachhaltige Steuerung der Belastung
empfohlen.
Schlussfolgerung Der funktionsbasierte Rehabilitationsansatz des
Return-to-Prozesses für die obere Extremität benötigt
einer einheitlichen Begriffsdefinition, sowie einer festgelegten Testbatterie,
deren Gütekriterien wissenschaftlich nachgewiesen wurden. Der
Return-to-Prozess muss funktions- und kraftbasierten Testverfahren beinhalten
und ergänzende Komponenten, wie akute und chronische
Belastungsverhältnisse einschließen.