bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alteration of eggs biochemical composition and progeny survival by maternal high carbohydrate nutrition in a teleost fish
Authors: Callet Therese , Cardona Emilie , Turonnet Nicolas , Maunas Patrick , Larroquet Laurence , Surget Anne , Corraze Genevieve , Panserat Stephane , Marandel Lucie 
Published: October 2022

AbstractReproductive performances, and the factors affecting them, are of major importance especially for farmed fish in the context of the development of a sustainable aquaculture. Dietary maternal lipids have been identified as a major factor affecting reproductive performances. Nevertheless, the consequences of carbohydrates have been little studied while plant-derived carbohydrates could be increasingly used in broodstock diets. To explore this issue, 2-year-old female trout were fed either a control diet that contains no carbohydrate and a high protein content (65.7%) or a diet formulated with plant-derived carbohydrates containing 32.5% carbohydrate and 42.9% protein (’HC diet’) for an entire reproductive cycle. The reproductive performances, the quality of the unfertilized eggs and the development of the progeny were carefully monitored. Although the one year HC nutrition had not impaired female growth nor spawns quality, such nutrition had increased the variability of eggs size within spawns (+ 34.0%). Moreover, the eggs produced had a modified fatty acid profile, including a significant reduction in EPA content (− 22.9%) and a significant increase in the AA/EPA ratio (+ 33.3%). The progeny were impacted by such alterations as their survival rates were significantly reduced. A lower plant-derived carbohydrate inclusion (20%) should be considered in aquafeed for female broodstock in trout.
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron
Authors: Palatnik-de-Sousa Iam , Wallace Zachary S. , Cavalcante Stephany Christiny , Ribeiro Maria Paula Fonseca , Silva João Antônio Barbosa Martins , Cavalcante Rafael Ciro , Scheuermann Richard H. , Palatnik-de-Sousa Clarisa Beatriz 
Published: October 2022

AbstractCOVID-19 caused, as of September, 1rst, 2022, 599,825,400 confirmed cases, including 6,469,458 deaths. Currently used vaccines reduced severity and mortality but not virus transmission or reinfection by different strains. They are based on the Spike protein of the Wuhan reference virus, which although highly antigenic suffered many mutations in SARS-CoV-2 variants, escaping vaccine-generated immune responses. Multiepitope vaccines based on 100% conserved epitopes of multiple proteins of all SARS-CoV-2 variants, rather than a single highly mutating antigen, could offer more long-lasting protection. In this study, a multiepitope multivariant vaccine was designed using immunoinformatics and in silico approaches. It is composed of highly promiscuous and strong HLA binding CD4+ and CD8+ T cell epitopes of the S, M, N, E, ORF1ab, ORF 6 and ORF8 proteins. Based on the analysis of one genome per WHO clade, the epitopes were 100% conserved among the Wuhan-Hu1, Alpha, Beta, Gamma, Delta, Omicron, Mµ, Zeta, Lambda and R1 variants. An extended epitope-conservancy analysis performed using GISAID metadata of 3,630,666 SARS-CoV-2 genomes of these variants and the additional genomes of the Epsilon, Lota, Theta, Eta, Kappa and GH490 R clades, confirmed the high conservancy of the epitopes. All but one of the CD4 peptides showed a level of conservation greater than 97% among all genomes. All but one of the CD8 epitopes showed a level of conservation greater than 96% among all genomes, with the vast majority greater than 99%. A multiepitope and multivariant recombinant vaccine was designed and it was stable, mildly hydrophobic and non-toxic. The vaccine has good molecular docking with TLR4 and promoted, without adjuvant, strong B and Th1 memory immune responses and secretion of high levels of IL-2, IFN-γ, lower levels of IL-12, TGF-β and IL-10, and no IL-6. Experimental in vivo studies should validate the vaccine’s further use as preventive tool with cross-protective properties.
Improved remnant polarization of Zr-doped HfO2 ferroelectric film by CF4/O2 plasma passivation
Authors: Choi Yejoo , Park Hyeonjung , Han Changwoo , Min Jinhong , Shin Changhwan 
Published: October 2022

AbstractIn this work, the impact of fluorine (CF4) and oxygen (O2) plasma passivation on HfZrOx (HZO) based ferroelectric capacitor was investigated. By the fluorine passivation, the surface trap density and oxygen vacancies in the HZO-based Metal–ferroelectric–insulator–semiconductor (MFIS) capacitors were suppressed, resulting in the increased pristine remnant polarization (2Pr). The pristine value (2Pr) of baseline samples annealed at 500 °C and 600 °C were 11.4 µC/cm2 and 24.4 µC/cm2, respectively. However, with the F–passivation, the 2Pr values were increased to 30.8 µC/cm2 and 48.2 µC/cm2 for 500 °C and 600 °C, respectively. The amount of surface defects and oxygen vacancies are quantitatively confirmed by the conductance method and XPS analysis. However, due to the incorporation of fluorine atoms into the ferroelectric–insulator films, undesirable degradation on endurance characteristics were observed.
Factors associated with two different stroke mechanisms in perforator infarctions regarding the shape of arteries
Authors: Ha Sang Hee , Ryu Jae-Chan , Bae Jae-Han , Koo Sujin , Chang Jun Young , Kang Dong-Wha , Kwon Sun U. , Kim Jong S. , Chang Dae-il , Kim Bum Joon 
Published: October 2022

AbstractTwo different stroke mechanisms are involved in small vessel disease: branch atheromatous disease (BAD) and lipohyalinotic degeneration (LD). We compared mechanisms of stroke in lenticulostriate arteries (LSA) vs. anterior pontine arteries (APA) and verified factors associated with stroke mechanisms, including shape of middle cerebral artery (MCA) and basilar artery (BA). We retrospectively reviewed patients with acute ischemic stroke with penetrating artery territory confirmed by MRI. The mechanisms of stroke were categorized based on diffusion-weighted imaging; BAD was defined as lesion larger than 10 mm in LSA and lesions involving basal pontine in APA. Other lesions were classified as LD. The shapes of MCA and BA were classified as straight, with one angle, or with two angles (U, C or S shape, respectively) using anterior–posterior view. The study included 221 patients. LD was more common in LSA infarcts, but BAD was more common in APA infarcts (p < 0.001). Low initial National Institutes of Health Stroke Scale [Adjusted Odds ratio (aOR) = 0.78; p < 0.001], absence of hyperlipidemia [aOR = 0.31; p = 0.002], previous statin use [aOR = 4.35; p = 0.028] LSA infarcts [reference = APA territory; aOR = 11.07; p < 0.001], and S-shaped vessels (reference = straight shaped vessels; aOR = 3.51; p = 0.004) were independently associated with LD. Angulations in the mother vessels may be more associated with true small vessel disease more with LD than BAD.
Indigenous bacteria as an alternative for promoting recycled paper and cardboard mill wastewater treatment
Authors: Gholami Maryam , Ghaneian Mohammad Taghi , Teimouri Fahimeh , Ehrampoush Mohammad Hassan , Nadoushan Abbasali Jafari , Jambarsang sara , Mahvi Amir Hossein 
Published: October 2022

AbstractThe present study aimed to investigate indigenous bacteria possibility in recycled paper and cardboard mill (RPCM) wastewater treatment through the isolation and identification of full-scale RPCM indigenous bacteria. The molecular characterization of the isolated bacteria was performed by 16S rRNA gene sequencing. Klebsiella pneumoniae AT-1 (MZ599583), Citrobacter freundii AT-4 (OK178569), and Bacillus subtilis AT-5 (MZ323975) were dominant strains used for RPCM wastewater bioremediation experiments. Under optimal conditions, the maximum values of chemical oxygen demand (COD) and color biodegradation by C. freundii AT-4 were 79.54% and 43.81% after 10 days of incubation, respectively. In the case of B. subtilis strain AT-5 and K. pneumoniae AT-1, the maximum values of COD and color biodegradation were 70.08%, 45.96%, 71.26%, and 32.06%, respectively. The results from optimal conditions regarding efficiency were higher in comparison with the efficiency obtained from the oxidation ditch treatment unit in full-scale RPCM-WWTP. Therefore, the present study introduces the isolated indigenous bacteria strains as a promising candidate for improving the RPCM-WWTP efficiency using bioremediation.
Observation-based trajectory of future sea level for the coastal United States tracks near high-end model projections
Authors: Hamlington Benjamin D. , Chambers Don P. , Frederikse Thomas , Dangendorf Soenke , Fournier Severine , Buzzanga Brett , Nerem R. Steven 
Published: October 2022

AbstractWith its increasing record length and subsequent reduction in influence of shorter-term variability on measured trends, satellite altimeter measurements of sea level provide an opportunity to assess near-term sea level rise. Here, we use gridded measurements of sea level created from the network of satellite altimeters in tandem with tide gauge observations to produce observation-based trajectories of sea level rise along the coastlines of the United States from now until 2050. These trajectories are produced by extrapolating the altimeter-measured rate and acceleration from 1993 to 2020, with two separate approaches used to account for the potential impact of internal variability on the future estimates and associated ranges. The trajectories are used to generate estimates of sea level rise in 2050 and subsequent comparisons are made to model-based projections. It is found that observation-based trajectories of sea level from satellite altimetry are near or above the higher-end model projections contained in recent assessment reports, although ranges are still wide.
Feasibility and ethics of using data from the Scottish newborn blood spot archive for research
Authors: Cunningham-Burley Sarah , McCartney Daniel L. , Campbell Archie , Flaig Robin , Orange Clare E. L. , Porteous Carol , Aitken Mhairi , Mulholland Ciaran , Davidson Sara , McCafferty Selena M. , Murphy Lee , Wrobel Nicola , McCafferty Sarah , Wallace Karen , StClair David , Kerr Shona , Hayward Caroline , McIntosh Andrew M. , Sudlow Cathie , Marioni Riccardo E. , Pell Jill , Miedzybrodzka Zosia , Porteous David J. 
Published: October 2022

Abstract
Background
Newborn heel prick blood spots are routinely used to screen for inborn errors of metabolism and life-limiting inherited disorders. The potential value of secondary data from newborn blood spot archives merits ethical consideration and assessment of feasibility for public benefit. Early life exposures and behaviours set health trajectories in childhood and later life. The newborn blood spot is potentially well placed to create an unbiased and cost-effective population-level retrospective birth cohort study. Scotland has retained newborn blood spots for all children born since 1965, around 3 million in total. However, a moratorium on research access is currently in place, pending public consultation.

Methods
We conducted a Citizens’ Jury as a first step to explore whether research use of newborn blood spots was in the public interest. We also assessed the feasibility and value of extracting research data from dried blood spots for predictive medicine.

Results
Jurors delivered an agreed verdict that conditional research access to the newborn blood spots was in the public interest. The Chief Medical Officer for Scotland authorised restricted lifting of the current research moratorium to allow a feasibility study. Newborn blood spots from consented Generation Scotland volunteers were retrieved and their potential for both epidemiological and biological research demonstrated.

Conclusions
Through the Citizens’ Jury, we have begun to identify under what conditions, if any, should researchers in Scotland be granted access to the archive. Through the feasibility study, we have demonstrated the potential value of research access for health data science and predictive medicine.
Stimulus- and Person-Level Variables Influence Word Production and Response to Anomia Treatment for Individuals With Chronic Poststroke Aphasia
Authors: Braun Emily J. , Kiran Swathi 
Published: October 2022

Purpose:
The impact of stimulus-level psycholinguistic variables and person-level semantic and phonological processing skills on treatment outcomes in individuals with aphasia requires further examination to inform clinical decision making in treatment prescription and stimuli selection. This study investigated the influence of stimulus-level psycholinguistic properties and person-level semantic and phonological processing skills on word production accuracy and treatment response.

Method:
This retrospective analysis included 35 individuals with chronic, poststroke aphasia, 30 of whom completed typicality-based semantic feature treatment. Mixed-effects logistic regression models were used to predict binary naming accuracy (a) at baseline and (b) over the course of treatment using stimulus-level psycholinguistic word properties and person-level semantic and phonological processing skills as predictors.

Results:
In baseline naming, words with less complex lexical–semantic and phonological properties showed greater predicted accuracy. There was also an interaction at baseline between stimulus-level lexical–semantic properties and person-level semantic processing skills in predicting baseline naming accuracy. With treatment, words that were more complex from a lexical–semantic standpoint (vs. less complex) and less complex from a phonological standpoint (vs. more complex) improved more. Individuals with greater baseline semantic and phonological processing skills showed a greater treatment response.

Conclusions:
This study suggests that future clinical research and clinical work should consider semantic and phonological properties of words in selecting stimuli for semantically based treatment. Furthermore, future clinical research should continue to evaluate baseline individual semantic and phonological profiles as predictors of response to semantically based treatment.

Supplemental Material:

https://doi.org/10.23641/asha.21256341
Fixed‐time fault‐tolerance attitude tracking control for spacecraft without unwinding
Authors: Huang Q. , Zhang Y. 
Published: October 2022

AbstractIn this paper, the attitude tracking control problem is investigated for rigid spacecraft subjected to external disturbance, inertia uncertainties, and actuator faults. The rotation matrix is used to model the spacecraft attitude control system which can get rid of the unwinding problem. A nonlinear observer is developed to achieve a high accuracy estimation for the lumped disturbance in fixedtime without the awareness of the boundary of disturbance. To restrain measurement noise, a tracking differentiator is used in the observer to construct signals instead of using the polluted measurement values. Based on the estimation provided by the disturbance observer, a fixed‐time attitude tracking controller is proposed by backstepping technique to stabilize attitude tracking errors in fixed time regardless of initial values. The singularity problem in traditional fixed‐time controllers based on signal function is eliminated with the help of the arctangent function in the proposed controller. The feature of the designed fixed‐time attitude controller is that it can suppress actuator faults, measurement noises and has no unwinding problem. Theoretical analysis based on Lyapunov theory and numerical simulations are presented to illustrate the robustness and effectiveness of the proposed control strategy.
A DC‐coupled 1.2 μW 0.012 mm2 per channel neural amplifiers array with 75 dB system common mode rejection ratio and 300 mV common mode interference
Authors: Wang Quan , You Changhua , Xue Ning , Zhang Xuan , Feng Chengcong , Zhao Zhengtuo , Yao Lei , Li Tie 
Published: October 2022

AbstractSystem common mode rejection ratio (SCMRR) and common mode interference (CMI) range are two critical design specifications for multiple‐channel neural recording front‐end circuit in a freely moving animal experiment environment. This letter presents a neural amplifiers array consisting of 15 DC‐coupled inverter‐based recording channels, a reference channel and a shared voltage averaging circuit (VAC) with floating rail Common Mode Feedback (CMFB) to achieve high SCMRR and large CMI range. Meanwhile, power consumption and area are optimized through using simple inverter architecture and removal of the conventional on‐chip AC‐coupled capacitors. The proposed neural amplifier circuit is implemented in SMIC standard 0.18 μm CMOS process, achieving a typical 75 dB SCMRR (DC‐80 Hz), 300 mV CMI range, 1.2 μW power consumption and 0.012 mm2 area per channel. The circuit is validated both by bench‐top test and in‐vivo animal experiment.
Contribution of neural networks in image steganography, watermarking and encryption
Authors: Rafidison Maminiaina Alphonse , Rafanantenana Sabine Harisoa Jacques , Rakotomihamina Andry Harivony , Toky Rajaonarison Faniriharisoa Maxime , Ramafiarisona Hajasoa Malalatiana 
Published: October 2022

AbstractIn front of information fishing, it is necessary to protect the information to be circulated over public channel. The goal of this paper is to propose an approach which inserts a logo inside of cover image and having three different possible results according to user's needs. The algorithm can perform steganography, watermarking or host encryption. This technique is based on singular value decomposition (SVD) and discrete wavelet transform (DWT) composed by three steps: pre‐processing, embedding and extraction/decryption. Reference matrix and reference parameter are the two factors deciding the operation and the intervention of neural networks makes the choice of their parameters easier according to the desired result. For measuring the steganography performance, the authors adopt the structural similarity index measure (SSIM) which calculates the similarity between original and watermarked image and peak signal‐to‐noise ratio. For watermarking, the normalized correlation (NC) coefficient investigates the correlation between the original watermark and the extracted watermark. Attacking the watermarked image with common attacks used by previous publication searchers, the value of SSIM and NC coefficient are closed to one. Regarding peak signal‐to‐noise ratio, the overall score is around 61.73 dB. The performance score is not negligible also for the encryption method.
A hybrid high‐efficiency nine‐level inverter with high DC voltage utilization ratio
Authors: Ren Qicai , Chen Alian , Liu Xi , Liu Tong 
Published: October 2022

AbstractThis paper proposes a new hybrid nine‐level inverter topology with high efficiency and high dc voltage utilization ratio, which provides a potential for renewable energy power conversion. The proposed inverter can synthesize up to nine voltage levels with only ten switching devices and a flying capacitor (FC). To improve the operation efficiency, a hybrid‐device topology based on Si and SiC is proposed. The total device cost of this inverter is much lower than the all‐SiC‐based inverter. Compared with other advanced multilevel inverters, a notable feature is the more comprehensive performance of the proposed inverter. In addition to having fewer components and higher efficiency, the dc voltage utilization ratio of the inverter is 2.5 times that of the traditional inverter such as Neutral Point Clamped (NPC), FC, and Active NPC (ANPC). A hybrid FC voltage balancing strategy based on redundancy switching states and three voltage levels step switching method is implemented to reduce FC voltage ripple. Besides, a cooperative voltage control strategy between the dc‐link capacitors and FC ensures the neutral‐point voltage balancing. The voltage stresses analysis and the design guidelines of components are discussed in detail. A comparison with some existing topologies has also been made to highlight its performance. Experimental results verify the validity of the proposed inverter topology and the control schemes.
Metabolite Profiling of Talatisamine in Heart Tissue After Oral Administration and Analysis of Cardiac Bioactivities
Authors: Huang Shuai , Lv Yang , Wang Jian-Zhu , Ye Mei-Zhen , Lu Rui-Jie , Chen Lin , Xie Jiang , Gao Feng , Zhou Xian-Li 
Published: October 2022

AbstractThe lateral roots of the Aconitum carmichaelii (“Fuzi”) have been used for centuries as a cardiotonic in China. The diterpenoid alkaloid talatisamine (TA) is a major bioactive
component of Fuzi, but the identity and bioactivities of the TA metabolites have not been examined in detail. In this study, metabolite profiling of TA was performed in rat heart by UPLC-MS
following oral administration. Metabolites were identified by comparing protonated molecules, fragmentation patterns, and chromatographic behaviors with those of standard compounds.
Metabolites of TA were then prepared and tested for cardiotonic activity on isolated frog hearts. The metabolite cammaconine, a C19 diterpenoid alkaloid with a hydroxyl group at
C-18, exhibited substantial cardiotonic activity during frog heart perfusion. To further investigate the structure–cardiac effect relationships, a series of C19-diterpenoid
alkaloids with 18-OH were prepared. Eight tested compounds (5–12) demonstrated measurable cardioactivity, of which compound 5 with an N-methyl group and compound
7 with a methoxy at C-16 showed stronger effects on ventricular contraction than the other compounds. Thus, 18-OH is a critical structural feature determining cardiotonic activity,
and efficacy is improved by the presence of N-methyl or methoxy at C-16. Preliminary mechanistic studies suggested that the cardiotonic effect of compound 5 is mediated by
enhanced cellular calcium influx. Metabolites of TA with these structural features may be useful therapeutics to prevent heart failure.
A Systematic Review Protocol on the Effect of Yoga Intervention on Inflammatory Biomarkers among Women with Breast Cancer
Authors: Kaje Kaini Cecilia , Dsilva Fatima , T. Latha , TS Sanal , D'Souza Caren , Kumar Shishir 
Published: October 2022

AbstractA systematic review protocol acts as a guide in the review process to prevent the introduction of bias, maintain transparency and allows reproducibility. Yoga intervention had been experimented on various health aspects such as physical functioning, health-related quality of life, psychosocial and emotional well-being among breast cancer populations, and the findings have been very encouraging. Studies are being performed on the effect of yoga intervention(s) at the molecular level by assessing the inflammatory cytokines and also stress hormones such as cortisol. This protocol is developed to escort in evaluating studies that have been performed on evidence-based yoga intervention at the level of cancer microenvironment, in women diagnosed with breast cancer, by assessing the inflammatory biomarkers and cortisol level, a primary stress marker, and a potent influence of inflammation. The findings will elucidate the picture of the cancer microenvironment as a result of yoga intervention.