bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinical study on relationship between visualization of cardiac fibroblast activation protein activity by Al18F-NOTA-FAPI-04 positron emission tomography and cardiovascular disease
Authors: Lyu Zhehao , Han Wei , Zhao Hongyue , Jiao Yuying , Xu Peng , Wang Yangyang , Shen Qiuyi , Yang Shuai , Zhao Changjiu , Tian Lin , Fu Peng 
Published: August 2022

ObjectiveFAP plays a vital role in myocardial injury and fibrosis. Although initially used to study imaging of primary and metastatic tumors, the use of FAPI tracers has recently been studied in cardiac remodeling after myocardial infarction. The study aimed to investigate the application of FAPI PET/CT imaging in human myocardial fibrosis and its relationship with clinical factors.Materials and methodsRetrospective analysis of FAPI PET/CT scans of twenty-one oncological patients from 05/2021 to 03/2022 with visual uptake of FAPI in the myocardium were applying the American Heart Association 17-segment model of the left ventricle. The patients’ general data, echocardiography, and laboratory examination results were collected, and the correlation between PET imaging data and the above data was analyzed. Linear regression models, Kendall’s TaU-B test, the Spearman test, and the Mann–Whitney U test were used for the statistical analysis.Results21 patients (60.1 ± 9.4 years; 17 men) were evaluated with an overall mean LVEF of 59.3 ± 5.4%. The calcific plaque burden of LAD, LCX, and RCA are 14 (66.7%), 12 (57.1%), and 9 (42.9%). High left ventricular SUVmax correlated with BMI (P &lt; 0.05) and blood glucose level (P &lt; 0.05), and TBR correlated with age (P &lt; 0.05). A strong correlation was demonstrated between SUVmean and CTnImax (r = 0.711, P &lt; 0.01). Negative correlation of SUVmean and LVEF (r = −0.61, P &lt; 0.01), SUVmax and LVEF (r = −0.65, P &lt; 0.01) were found. ROC curve for predicting calcified plaques by myocardial FAPI uptake (SUVmean) in LAD, LCX, and RCA territory showed AUCs were 0.786, 0.759, and 0.769.ConclusionFAPI PET/CT scans might be used as a new potential method to evaluate cardiac fibrosis to help patients’ management further. FAPI PET imaging can reflect the process of myocardial fibrosis. High FAPI uptakes correlate with cardiovascular risk factors and the distribution of coronary plaques.
Lung ultrasound-guided treatment for heart failure: An updated meta-analysis and trial sequential analysis
Authors: Li Yan , Ai Hu , Ma Na , Li Peng , Ren Junhong 
Published: August 2022

BackgroundThe usefulness of lung ultrasound (LUS) in guiding heart failure (HF) treatment is still controversial.PurposeWe aimed to evaluate the usefulness of LUS-guided treatment vs. usual care in reducing the major adverse cardiac event (MACE) rate in patients with HF.Materials and methodsWe performed a systematic review and meta-analysis of randomized controlled trials (RCTs) identified through systematic searches of MEDLINE, EMBASE, the Cochrane Database, Google Scholar, and SinoMed. The primary outcome was MACEs (a composite of all-cause mortality, HF-related rehospitalization, and symptomatic HF). The required information size was calculated by trial sequential analysis (TSA).ResultsIn total, ten RCTs involving 1,203 patients were included. Overall, after a mean follow-up period of 4.7 months, LUS-guided treatment was associated with a significantly lower risk of MACEs than usual care [relative risk (RR), 0.59; 95% confidence interval (CI), 0.48–0.71]. Moreover, the rate of HF-related rehospitalization (RR, 0.63; 95% CI, 0.40–0.99) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration (standardized mean difference, –2.28; 95% CI, –4.34 to –0.22) were markedly lower in the LUS-guided treatment group. The meta-regression analysis showed a significant correlation between MACEs and the change in B-line count (p &lt; 0.05). The subgroup analysis revealed that the risk of MACEs was markedly lower in patients aged up to 70 years (RR, 0.54; 95% CI, 0.44–0.67), with a lower rate of atrial fibrillation (&lt; 27.2%) (RR, 0.53; 95% CI, 0.43–0.67), and with a lower NT-proBNP concentration (&lt; 3,433 pg/ml) (RR, 0.51; 95% CI, 0.40–0.64). TSA indicated a lower risk of MACEs with LUS-guided treatment than with usual care among patients with HF (p &lt; 0.05).ConclusionLung ultrasound seems to be a safe and effective method to guide HF treatment.Systematic review registration[https://inplasy.com/], identifier [INPLASY202220124].
Effect of preoperative pulse oximeter oxygen saturation on postoperative prolonged mechanical ventilation in patients with tetralogy of Fallot
Authors: Wu Xie , An Ran , Luo Qipeng , Li Yinan , Wang Hongbai , Liu Qiao , Huang Jiangshan , Jia Yuan , Yuan Su , Yan Fuxia 
Published: August 2022

BackgroundAs an easily accessible and intervened clinical indicator, preoperative pulse oximeter oxygen saturation (SpO2) is an important factor affecting the prognosis of patients with tetralogy of Fallot (TOF). However, whether SpO2 is associated with postoperative mechanical ventilation (MV) time remains unknown. Therefore, this study aimed to investigate the impact of preoperative SpO2 on postoperative prolonged mechanical ventilation (PMV) in children with TOF.Materials and methodsThe study included children younger than 18 years who underwent corrective operations for TOF between January 2016 and December 2018 in Fuwai Hospital, China. Univariate and multivariate logistic regression analyses were used to evaluate the influence of preoperative SpO2 on postoperative PMV. After identifying SpO2 as an independent risk factor for PMV, patients were further divided into two groups according to the cutoff value of SpO2, and propensity score matching (PSM) analysis was used to eliminate the effect of confounding factors. The logistic regression was used to compare the outcomes between the two groups after PSM.ResultsA total of 617 patients were finally enrolled in this study. By the univariable and multivariate logistic analysis, four independent risk factors for PMV were determined, namely, SpO2, surgical technique, aortic cross-clamp time, and intraoperative minimum temperature. According to the outcomes of 219 paired patients after PSM, the incidence of PMV was significantly higher in patients with lower preoperative SpO2 (P = 0.022). Also, there was significant increase in mechanical ventilation time (P = 0.019), length of intensive care unit stay (P = 0.044), postoperative hospital stay (P = 0.006), hospital stay (P = 0.039), and hospitalization cost (P = 0.019) at the lower preoperative SpO2 level.ConclusionLow preoperative SpO2 represents an independent risk factor of postoperative PMV in children with TOF.
Multi-parametric study of an eruptive phase comprising unrest, major explosions, crater failure, pyroclastic density currents and lava flows: Stromboli volcano, 1 December 2020–30 June 2021
Authors: Calvari S. , Di Traglia F. , Ganci G. , Bruno V. , Ciancitto F. , Di Lieto B. , Gambino S. , Garcia A. , Giudicepietro F. , Inguaggiato S. , Vita F. , Cangemi M. , Inguaggiato C. , Macedonio G. , Mattia M. , Miraglia L. , Nolesini T. , Pompilio M. , Romano P. , Salerno G. , Casagli N. , Re G. , Del Carlo P. , Di Roberto A. , Cappello A. , Corradino C. , Amato E. , Torrisi F. , Del Negro C. , Esposito A. M. , De Cesare W. , Caputo T. , Buongiorno M. F. , Musacchio M. , Romaniello V. , Silvestri M. , Marotta E. , Avino R. , Avvisati G. , Belviso P. 
Published: August 2022

Open conduit volcanoes like Stromboli can display elusive changes in activity before major eruptive events. Starting on December 2020, Stromboli volcano displayed an increasing eruptive activity, that on 19 May 2021 led to a crater-rim collapse, with pyroclastic density currents (PDCs) that spread along the barren NW flank, entered the sea and ran across it for more than 1 km. This episode was followed by lava flow output from the crater rim lasting a few hours, followed by another phase of lava flow in June 2021. These episodes are potentially very dangerous on island volcanoes since a landslide of hot material that turns into a pyroclastic density current and spreads on the sea surface can threaten mariners and coastal communities, as happened at Stromboli on 3 July and 28 August 2019. In addition, on entering the sea, if their volume is large enough, landslides may trigger tsunamis, as occurred at Stromboli on 30 December 2002. In this paper, we present an integration of multidisciplinary monitoring data, including thermal and visible camera images, ground deformation data gathered from GNSS, tilt, strainmeter and GBInSAR, seismicity, SO2 plume and CO2 ground fluxes and thermal data from the ground and satellite imagery, together with petrological analyses of the erupted products compared with samples from previous similar events. We aim at characterizing the preparatory phase of the volcano that began on December 2020 and led to the May–June 2021 eruptive activity, distinguishing this small intrusion of magma from the much greater 2019 eruptive phase, which was fed by gas-rich magma responsible for the paroxysmal explosive and effusive phases of July–August 2019. These complex eruption scenarios have important implications for hazard assessment and the lessons learned at Stromboli volcano may prove useful for other open conduit active basaltic volcanoes.
Spatial–temporal variations in natural disasters during the Ming and Qing dynasties (1368–1911 AD) in the ancient Huizhou region, eastern China
Authors: Lu Shuguang , Wu Li , Cheng Xianfu , Xu Guanglai , Shen Fei , Li Chenchen , Hu Xiaosi , Yang Baodong , Zhang Hongmei , Li Xiaoxue 
Published: August 2022

The Little Ice Age (LIA) during the Ming and Qing dynasties was the most abnormal climate event in China for nearly 2,000 years. During this period, the climate was relatively cold and various natural disasters frequently took place. By locating and compiling related historical documents, we aimed to quantitatively and systematically analyze the spatial–temporal variations in the natural disasters in the ancient Huizhou region (hereinafter referred to as Huizhou region or Huizhou) during the Ming and Qing dynasties (1368–1911; all dates are in AD, unless otherwise mentioned). The results show that (1) flood and drought disasters, the major types of disasters in this area during the Ming and Qing dynasties, occurred 422 times, accounting for 79.6% of the natural disasters, (2) there was a significant correlation of occurrence frequency of flood plus drought disasters and the total natural disasters on a certain time scale. In addition to flood and drought disasters, other disasters (hailstorms, windstorms, frosts, and earthquakes) occurred more frequently in the Qing dynasty (1644–1911) than in the Ming dynasty (1368–1644). The occurrence frequency of natural disasters had a fluctuant variation pattern over time, with peaks emerging about once a century. The peaks of natural disasters were mainly concentrated at 1471–1490, 1571–1590, 1671–1690, 1751–1770, and 1851–1870, which is supported by the wavelet analysis, (3) the most frequent natural disasters took place in Wuyuan, followed by Jixi, Shexian, Xiuning, Qimen, and Yixian. More droughts occurred in Jixi and Yixian, while more floods occurred in Wuyuan, Shexian, and Qimen, more hailstorms occurred in Wuyuan and Jixi, more frost disasters occurred in Wuyuan, Jixi, and Qimen, and more earthquakes occurred in Wuyuan and Jixi. The occurrence frequency of wind disasters was not high in any of the counties, (4) flood and drought disasters in the Huizhou region exhibited obvious stage characteristics during the Ming and Qing dynasties, and they changed gradually from droughts to floods, among which the transition from slight drought to slight flooding was the most obvious during 1811–1911, and (5) overall, slight flooding and slight drought situations accounted for the largest percentage of drought and flood disasters in this area during the Ming and Qing dynasties. Among these, slight flooding mainly occurred in Shexian and Qimen; severe flooding mainly occurred in Wuyuan; slight drought mainly occurred in Yixian; and severe drought mainly occurred in Jixi.
Safety and efficacy of thermal ablation for cervical metastatic lymph nodes in papillary thyroid carcinoma: A systematic review and meta-analysis
Authors: Tang Wanqing , Tang Xiuyun , Jiang Danni , Zhang Xiaojuan , Wang Rongling , Niu Xiaoyan , Zang Yichen , Zhang Mingzhu , Wang Xinya , Zhao Cheng 
Published: August 2022

BackgroundTo evaluate the safety and efficacy of radiofrequency ablation (RFA), microwave ablation (MWA), and laser ablation (LA) for the treatment of cervical metastatic lymph nodes (CMLNs) of papillary thyroid carcinoma (PTC).MethodsThe Pubmed, EMBASE, Web of Science, and Cochrane Library databases were searched for studies on the safety and efficacy of thermal ablations (RFA, MWA, and LA) for the treatment of CMLNs of PTC until March 30, 2022. A review of 334 potential papers identified 17 eligible papers including 312 patients. Fixed-effects model or random-effects model was used to evaluate the pooled proportions of volume reduction rate (VRR), complete disappearance, and recurrence, and pooled estimates of changes in the largest diameter, volume, and serum Tg after ablation. The pooled proportions of overall and major complications were calculated. Subgroup analysis based on treatment modalities. The heterogeneity among studies was analyzed by using Q statistics and inconsistency index I2. MINORS scale was used to evaluate the quality of the studies.Results17 eligible studies were finally identified, including 312 patients and 559 CMLNs. The pooled proportions of VRR, complete disappearance and recurrence of CMLNs were 91.28% [95% confidence interval (CI): 86.60-95.97%], 67.9% [95% CI: 53.1-81.1%] and 7.8% [95%CI: 3.0-14.1%], respectively. The pooled estimates of changes in the largest diameter, volume and serum Tg were 8.12 mm [95%CI: 6.78-9.46 mm], 338.75 mm3 [95%CI: 206.85 -470.65 mm3] and 5.96 ng/ml [95%CI: 3.68-8.24 ng/ml], respectively. The pooled proportions of overall and major complications were 2.9% [95%CI: 0.3-7.1%] and 0.3% [95%CI: 0-1.9%], respectively. Significant between-study heterogeneity was observed for complete disappearance (P&lt;0.01, I2 =88.6%), VRR (P&lt;0.001, I2 =99.9%), recurrence (P=0.02, I2 =47.76%), overall complications (P&lt;0.02, I2 =44.8%), and changes in the largest diameter (P &lt; 0.001, I2 =82.6%), volume (P&lt;0.001, I2 =97.0%), and serum Tg (P &lt; 0.001, I2 =93.7%). Subgroup analysis showed heterogeneity of the VRR among the treatment modality (I2 range: 84.4-100%). The VRR of MWA was the highest (97.97%), followed by RFA (95.57%) and LA (84.46%) (P &lt; 0.001).ConclusionAll thermal ablations were safe and effective for the treatment of CMLNs of PTC. However, each treatment had significant heterogeneity in VRR. Compared with RFA and MWA, LA was less effective in reducing the volume of CMLNs of PTC.
Groundwater depth alters soil nutrient concentrations in different environments in an arid desert
Authors: Zhang Bo , Zeng Fanjiang , Gao Xiaopeng , Shareef Muhammad , Zhang Zhihao , Yu Qiang , Gao Yanju , Li Changjun , Yin Hui , Lu Yan , Huang Caibian , Tang Gangliang 
Published: August 2022

Soil nutrients are vital for plant growth and survival and present a crucial role in terrestrial function and productivity. However, little is known about the effect mechanism of groundwater table on soil nutrients in an arid desert ecological system. This study investigated the impacts of groundwater depth on the concentrations of soil organic carbon (C), available nitrogen (N), phosphorus (P), and potassium (K) at shallow groundwater depths (0.4, 0.8, 1.2, 1.8, and 2.2 m) and field deep groundwater depths (2.5, 4.5, and 11.0 m) in a desert-oasis ecotone in Central Asia in 2015 and 2016. Soil nitrate-N, inorganic-N, soil available P, and K concentrations were significantly affected by shallow and field deep groundwater. Groundwater depths did not alter soil ammonium-N concentration. Soil organic C concentration was influenced by field deep groundwater depth. Structural equation model showed that groundwater depth directly affected soil nitrate-N and K concentrations and indirectly altered the soil inorganic-N, soil organic C and available P concentrations in shallow groundwater. Moreover, groundwater depth directly influenced soil nitrate-N and soil organic C, available P and K concentrations and indirectly affected soil inorganic-N concentration in deep groundwater. Hence, groundwater depth should be considered one of the most critical environmental factors affecting soil nutrient variation in an arid desert. This study provides new insights into the soil nutrient variation under a declining groundwater depth in a hyper-arid ecosystem.
Development and validation of immune-based biomarkers and deep learning models for Alzheimer’s disease
Authors: He Yijie , Cong Lin , He Qinfei , Feng Nianping , Wu Yun 
Published: August 2022

Background: Alzheimer’s disease (AD) is the most common form of dementia in old age and poses a severe threat to the health and life of the elderly. However, traditional diagnostic methods and the ATN diagnostic framework have limitations in clinical practice. Developing novel biomarkers and diagnostic models is necessary to complement existing diagnostic procedures.Methods: The AD expression profile dataset GSE63060 was downloaded from the NCBI GEO public database for preprocessing. AD-related differentially expressed genes were screened using a weighted co-expression network and differential expression analysis, and functional enrichment analysis was performed. Subsequently, we screened hub genes by random forest, analyzed the correlation between hub genes and immune cells using ssGSEA, and finally built an AD diagnostic model using an artificial neural network and validated it.Results: Based on the random forest algorithm, we screened a total of seven hub genes from AD-related DEGs, based on which we confirmed that hub genes play an essential role in the immune microenvironment and successfully established a novel diagnostic model for AD using artificial neural networks, and validated its effectiveness in the publicly available datasets GSE63060 and GSE97760.Conclusion: Our study establishes a reliable model for screening and diagnosing AD that provides a theoretical basis for adding diagnostic biomarkers for the AD gene.
The landscape of circular RNA in preterm birth
Authors: Ran Yuxin , Chen Ruixin , Huang Dongni , Qin Yan , Liu Zheng , He Jie , Mei Youwen , Zhou Yunqian , Yin Nanlin , Qi Hongbo 
Published: August 2022

BackgroundPreterm birth (PTB) is a multifactorial syndrome that seriously threatens the health of pregnant women and babies worldwide. Recently, circular RNAs (circRNAs) have been understood as important regulators of various physiological and pathological processes. However, the expression pattern and potential roles of circRNAs in PTB are largely unclear.MethodsIn this study, we extracted and analyzed the circRNA expression profiles in maternal and fetal samples of preterm and term pregnancies, including maternal plasma, maternal monocytes, myometrium, chorion, placenta, and cord blood. We identified the circRNAs which is associated with PTB in different tissues and explored their relationships from the perspective of the overall maternal-fetal system. Furthermore, co-expression analysis of circRNAs and mRNAs, target microRNAs (miRNAs), and RNA-binding proteins (RBPs), provided new clues about possible mechanisms of circRNA function in PTB. In the end, we investigated the potential special biofunctions of circRNAs in different tissues and their common features and communication in PTB.ResultsSignificant differences in circRNA types and expression levels between preterm and term groups have been proved, as well as between tissues. Nevertheless, there were still some PTB-related differentially expressed circRNAs (DECs) shared by these tissues. The functional enrichment analysis showed that the DECs putatively have important tissue-specific biofunctions through their target miRNA and co-expressed mRNAs, which contribute to the signature pathologic changes of each tissue within the maternal-fetal system in PTB (e.g., the contraction of the myometrium). Moreover, DECs in different tissues might have some common biological activities, which are mainly the activation of immune-inflammatory processes (e.g., interleukin1/6/8/17, chemokine, TLRs, and complement).ConclusionsIn summary, our data provide a preliminary blueprint for the expression and possible roles of circRNAs in PTB, which lays the foundation for future research on the mechanisms of circRNAs in PTB.
North Pacific minke whales call rapidly when calling conspecifics are nearby
Authors: Martin Cameron R. , Guazzo Regina A. , Helble Tyler A. , Alongi Gabriela C. , Durbach Ian N. , Martin Stephen W. , Matsuyama Brian M. , Henderson E. Elizabeth 
Published: August 2022

North Pacific minke whale (Balaenoptera acutorostrata) boing calls are commonly detected in Hawaiian waters. When producing boing vocalizations, minke whales seem to be in one of two calling behavioral states. Most often minke whales produce boings with inter-call intervals of several minutes, but sometimes minke whales call rapidly with inter-call intervals of less than a minute. Since minke whales are difficult to detect visually, cue-rate-based density estimation using passive acoustic monitoring has been proposed. However, the variables that influence cue rate or calling rate are poorly understood in most whales, including minke whales. We collected passive acoustic recordings from 47 bottom-mounted hydrophones at the Pacific Missile Range Facility’s instrumented range off the coast of Kauaʻi, Hawaiʻi to test the hypothesis that minke whales call more rapidly when closer in proximity to other calling conspecifics. A total of 599 days of data were recorded between August 2012 and July 2017 and were automatically post-processed to detect, classify, and localize calls. Localized calls were grouped into tracks and manually validated, resulting in 509 individual tracks composed of 36,033 calls within a 16 x 39 km focal study area. Tracked minke whales exhibited a strong bimodal call rate with means of one call every 6.85 min (σ= 2.54 min) and 0.63 min (σ= 0.36 min). We ran hidden Markov models to quantify the relationship between call rate and the distance to the nearest calling conspecific. Overall, the probability of the higher call rate occurring increased as the distance to the nearest conspecific decreased, and the probability of the lower call rate occurring increased as the distance to the nearest conspecific increased. We also examined individual track data and found that minke whales may also exhibit other responses (i.e. increased speed, changes in heading, and cessation of calling) when calling conspecifics are nearby. These findings provide new information about minke whale calling behavior in what is likely a breeding area.