bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroweak ALP searches at a muon collider
Authors: Bao Yunjia , Fan JiJi , Li Lingfeng 
Published: August 2022

AbstractA high-energy muon collider with center-of-mass energy around and above 10 TeV is also a vector boson fusion (VBF) machine, due to the significant virtual electroweak (EW) gauge boson content of high-energy muon beams. This feature, together with the clean environment, makes it an ideal collider to search for TeV-scale axion-like particles (ALP) coupling to Standard Model EW gauge bosons, which current and other future colliders have limited sensitivities to. We present detailed analyses of heavy ALP searches in both the VBF and associated production channels at a muon collider with different running benchmarks. We also show projected constraints on the ALP couplings in the effective field theory, including an operator with its coefficient not determined by the mixed Peccei-Quinn anomaly. We demonstrate that a muon collider could probe new ALP parameter space and push the sensitivities of the couplings between the ALP and EW gauge bosons by one order of magnitude compared to HL-LHC. The projected limits and search strategies for ALPs could also be applied to other types of resonances coupling to EW gauge bosons.
Transcendental Properties of Entropy-Constrained Sets
Authors: Blakaj Vjosa , Wolf Michael M. 
Published: August 2022

AbstractFor information-theoretic quantities with an asymptotic operational characterization, the question arises whether an alternative single-shot characterization exists, possibly including an optimization over an ancilla system. If the expressions are algebraic and the ancilla is finite, this leads to semialgebraic level sets. In this work, we provide a criterion for disproving that a set is semialgebraic based on an analytic continuation of the Gauss map. Applied to the von Neumann entropy, this shows that its level sets are nowhere semialgebraic in dimension$$d\ge 3$$d≥3, ruling out algebraic single-shot characterizations with finite ancilla (e.g., via catalytic transformations). We show similar results for related quantities, including the relative entropy, and discuss under which conditions entropy values are transcendental, algebraic, or rational.
Long-term outcomes after using retrievable vena cava filters in major trauma patients with contraindications to prophylactic anticoagulation
Authors: Ho Kwok M. , Patel Priya , Chamberlain Jenny , Nasim Sana , Rogers Frederick B. 
Published: August 2022

Abstract
Purpose
To investigate the long-term outcomes of using vena cava filters to prevent symptomatic pulmonary embolism (PE) in major trauma patients who have contraindications to prophylactic anticoagulation.

Methods
This was an a priori sub-study of a randomized controlled trial (RCT) involving long-term outcome data of 223 patients who were enrolled in Western Australia. State-wide clinical information system, radiology database and death registry were used to assess long-term outcomes, including incidences of venous thromboembolism, venous injury and mortality beyond day-90 follow-up.

Results
The median follow-up time of 198 patients (89%) who survived beyond 90 days was 65 months (interquartile range 59–73). Ten patients (5.1%) died after day-90 follow-up; and four patients developed venous thromboembolism, including two with symptomatic PE, all allocated to the control group (0 vs 4%, p = 0.043). Inferior vena cava injuries were not recorded in any patients. The mean total hospitalization cost, including the costs of the filter and its insertion and removal, to prevent one short- or long-term symptomatic PE was A$284,820 (€193,678) when all enrolled patients were considered. The number of patients needed to treat (NNT = 5) and total hospitalization cost to prevent one symptomatic PE (A$1,205 or €820) were, however, substantially lower when the filter was used only for patients who could not be anticoagulated within seven days of injury.

Conclusion
Long-term complications related to retrievable filters were rare, and the cost of using filters to prevent symptomatic PE was acceptable when restricted to those who could not be anticoagulated within seven days of severe injury.
Praxis der perioperativen Prävention von Phantomschmerz: eine deutschlandweite Umfrage
Authors: Wandrey Jan D. , Schäfer Michael , Erlenwein Joachim , Tafelski Sascha 
Published: August 2022

Zusammenfassung
Hintergrund
Phantomschmerzen haben eine hohe Prävalenz nach Majoramputationen und sind mit einer zusätzlichen Einschränkung der Lebensqualität verbunden. Perioperative Behandlungsstrategien könnten zur Prävention von Phantomschmerzen beitragen. Diese Studie soll die aktuelle Praxis des perioperativen anästhesiologischen Schmerzmanagements bei Majoramputation darstellen, eine Einschätzung des Optimierungspotenzials und eine Barriereanalyse für die Versorgung dieser Patientenpopulation erarbeiten.

Material und Methoden
In einer Onlineumfrage aus dem Wissenschaftlichen Arbeitskreis Schmerzmedizin der Deutschen Gesellschaft für Anästhesiologie e. V. (DGAI) wurden alle Fachärztinnen und Fachärzte für Anästhesiologie der Gesellschaft um Teilnahme gebeten und anonymisiert befragt.

Ergebnisse
Insgesamt 402 Antworten zeigten, dass aktuell meist eine Allgemeinanästhesie (85 %), ein Verfahren der Leitungs- oder Plexusanästhesie (63 %) oder eine rückenmarknahe Anästhesie (49 %) in unterschiedlichen Kombinationen durchgeführt wurden. Des Weiteren gaben 72 % der Antwortenden an, postoperativ i.v.-Opioide zu nutzen, wobei 57 % eine patientenkontrollierte Analgesie (PCA) verwendeten. Demgegenüber wurden beim Einsatz präoperativer Regionalverfahren (74 %) und präoperativer Gabapentinoide (67 %) Ansätze zur Behandlungsoptimierung gesehen. Insbesondere organisatorische wie auch patientenimmanente Faktoren wurden als Barrieren bei der Versorgung benannt.

Diskussion
Die Umfrage bildet die aktuelle Praxis des perioperativen Schmerzmanagements bei Majoramputationen ab. Es deutet sich an, dass Bedarf für eine bereits präoperativ eingebundene, schmerzmedizinische Behandlung besteht. Vor dem Hintergrund der eingeschränkten Evidenz von aktuellen Therapieempfehlungen lassen sich aus der dargestellten Versorgungspraxis Fragestellungen für weitere Studien ableiten.
Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening
Authors: Weiss Andreas , Zapardiel-Gonzalo Jose , Voss Franziska , Jolink Manja , Stock Joanna , Haupt Florian , Kick Kerstin , Welzhofer Tiziana , Heublein Anja , Winkler Christiane , Achenbach Peter , Ziegler Anette-Gabriele , Bonifacio Ezio ,   for the Fr1da-study group
Published: August 2022

Abstract
Aims/hypothesis
The aim of this study was to develop strategies that identify children from the general population who have late-stage presymptomatic type 1 diabetes and may, therefore, benefit from immune intervention.

Methods
We tested children from Bavaria, Germany, aged 1.75–10 years, enrolled in the Fr1da public health screening programme for islet autoantibodies (n=154,462). OGTT and HbA1c were assessed in children with multiple islet autoantibodies for diagnosis of presymptomatic stage 1 (normoglycaemia) or stage 2 (dysglycaemia) type 1 diabetes. Cox proportional hazards and penalised logistic regression of autoantibody, genetic, metabolic and demographic information were used to develop a progression likelihood score to identify children with stage 1 type 1 diabetes who progressed to stage 3 (clinical) type 1 diabetes within 2 years.

Results
Of 447 children with multiple islet autoantibodies, 364 (81.4%) were staged. Undiagnosed stage 3 type 1 diabetes, presymptomatic stage 2, and stage 1 type 1 diabetes were detected in 41 (0.027% of screened children), 30 (0.019%) and 293 (0.19%) children, respectively. The 2 year risk for progression to stage 3 type 1 diabetes was 48% (95% CI 34, 58) in children with stage 2 type 1 diabetes (annualised risk, 28%). HbA1c, islet antigen-2 autoantibody positivity and titre, and the 90 min OGTT value were predictors of progression in children with stage 1 type 1 diabetes. The derived progression likelihood score identified substages corresponding to ≤90th centile (stage 1a, n=258) and >90th centile (stage 1b, n=29; 0.019%) of stage 1 children with a 4.1% (95% CI 1.4, 6.7) and 46% (95% CI 21, 63) 2 year risk of progressing to stage 3 type 1 diabetes, respectively.

Conclusions/interpretation
Public health screening for islet autoantibodies found 0.027% of children to have undiagnosed clinical type 1 diabetes and 0.038% to have undiagnosed presymptomatic stage 2 or stage 1b type 1 diabetes, with 50% risk to develop clinical type 1 diabetes within 2 years.

Graphical abstract
Facets of ICP-MS and their potential in the medical sciences—Part 1: fundamentals, stand-alone and hyphenated techniques
Authors: Clases David , Gonzalez de Vega Raquel 
Published: August 2022

AbstractSince its inception in the early 80s, inductively coupled plasma–mass spectrometry has developed to the method of choice for the analysis of elements in complex biological systems. High sensitivity paired with isotopic selectivity and a vast dynamic range endorsed ICP-MS for the inquiry of metals in the context of biomedical questions. In a stand-alone configuration, it has optimal qualities for the biomonitoring of major, trace and toxicologically relevant elements and may further be employed for the characterisation of disrupted metabolic pathways in the context of diverse pathologies. The on-line coupling to laser ablation (LA) and chromatography expanded the scope and application range of ICP-MS and set benchmarks for accurate and quantitative speciation analysis and element bioimaging. Furthermore, isotopic analysis provided new avenues to reveal an altered metabolism, for the application of tracers and for calibration approaches. In the last two decades, the scope of ICP-MS was further expanded and inspired by the introduction of new instrumentation and methodologies including novel and improved hardware as well as immunochemical methods. These additions caused a paradigm shift for the biomedical application of ICP-MS and its impact in the medical sciences and enabled the analysis of individual cells, their microenvironment, nanomaterials considered for medical applications, analysis of biomolecules and the design of novel bioassays. These new facets are gradually recognised in the medical communities and several clinical trials are underway. Altogether, ICP-MS emerged as an extremely versatile technique with a vast potential to provide novel insights and complementary perspectives and to push the limits in the medical disciplines. This review will introduce the different facets of ICP-MS and will be divided into two parts. The first part will cover instrumental basics, technological advances, and fundamental considerations as well as traditional and current applications of ICP-MS and its hyphenated techniques in the context of biomonitoring, bioimaging and elemental speciation. The second part will build on this fundament and describe more recent directions with an emphasis on nanomedicine, immunochemistry, mass cytometry and novel bioassays.
Graphical abstract
Quantitative PET imaging of the CD4 pool in nonhuman primates
Authors: Kim Insook , Srinivasula Sharat , DeGrange Paula , Long Brad , Jang Hyukjin , Carrasquillo Jorge A. , Lane H. Clifford , Di Mascio Michele 
Published: August 2022

AbstractPurposePrevious SPECT and PET semi-quantitative in vivo imaging studies in monkeys have demonstrated specific uptake of radiolabeled rhesus recombinant anti-CD4 monoclonal antibody fragment CD4R1-F(ab΄)2in the spleen and clusters of lymph nodes (LNs) but yielded conflicting results of imaging the gut CD4 + T-cell pool. Here, using PET dynamic imaging with kinetic analysis, we performed a fully quantitative CD4 imaging in rhesus macaques.MethodsThe biodistributions of [89Zr]Zr-CD4R1-F(ab΄)2and/or of [89Zr]Zr-ibalizumab were performed with static PET scans up to 144 h (6 days) post-injection in 18 rhesus macaques with peripheral blood CD4 + T cells/μl ranging from ~ 20 to 2400. Fully quantitative analysis with a 4-h dynamic scan, arterial sampling, metabolite evaluation, and model fitting was performed in three immunocompetent monkeys to estimate the binding potential of CD4 receptors in the LNs, spleen, and gut.ResultsThe biodistributions of [89Zr]Zr-CD4R1-F(ab΄)2and [89Zr]Zr-ibalizumab were similar in lymphoid tissues with a clear delineation of the CD4 pool in the LNs and spleen and a significant difference in lymphoid tissue uptake between immunocompetent and immunocompromised macaques. Consistent with our previous SPECT imaging of [99mTc]Tc-CD4R1-F(ab΄)2, the [89Zr]Zr-CD4R1-F(ab΄)2and [89Zr]Zr-Ibalizumab uptakes in the gut were low and not different between uninfected and SIV-infected CD4-depleted monkeys. Ex vivo studies of large and small intestines confirmed the in vivo images.ConclusionThe majority of specific binding to CD4 + tissue was localized to LNs and spleen with minimal uptake in the gut. Binding potential derived from fully quantitative studies revealed that the contribution of the gut is lower than the spleen’s contribution to the total body CD4 pool.
Coastal Land Use Management Methodologies under Pressure from Climate Change and Population Growth
Authors: Wu Tao , Barrett Juliana 
Published: August 2022

AbstractThroughout history, humans living in the coastal area constantly adapt to the natural environment and create a changing environment. The rapid coastal development occurred in the mid-19th century and peaks in the mid-20th century, which was a common process in most industrialized areas. With increasing population growth and urban sprawl, many coastal lowlands are unprecedently vulnerable to climate change impacts such as sea level rise, increasing extreme storm events, and coastal flooding. Under the influence of urban revitalization and conservation, the landward shoreline movement accelerated and coastal land shrank, accompanied by community retreat. This research focuses on the importance of incorporating an understanding of the changing coastal land-ocean interaction into adaptive management strategies by illustrating the relationship of land use change, social-economic development, and climate change. Typical coastal changes in Connecticut were selected: New Haven Harbor reflects a dramatic seaward land accretion under industrial and transportation development, New London downtown waterfront reveals a trend of building retreat under industrial and commercial transformation and coastal hazard, New London Ocean Beach indicates how overdeveloped coastal low-lying community fully retreat after a natural disaster, and Jordan Cove barrier island shows a highly dynamic coastal land change and proactive management strategy. The results reveal that to cope with a constantly changing shoreline and the challenges of climate change, a resilient management process must incorporate a cycle of learning, experimenting, and creating with the goal of developing new solutions that are able to deal with our ever-changing environment.
Statistical analysis and first-passage-time applications of a lognormal diffusion process with multi-sigmoidal logistic mean
Authors: Di Crescenzo Antonio , Paraggio Paola , Román-Román Patricia , Torres-Ruiz Francisco 
Published: August 2022

AbstractWe consider a lognormal diffusion process having a multisigmoidal logistic mean, useful to model the evolution of a population which reaches the maximum level of the growth after many stages. Referring to the problem of statistical inference, two procedures to find the maximum likelihood estimates of the unknown parameters are described. One is based on the resolution of the system of the critical points of the likelihood function, and the other is on the maximization of the likelihood function with the simulated annealing algorithm. A simulation study to validate the described strategies for finding the estimates is also presented, with a real application to epidemiological data. Special attention is also devoted to the first-passage-time problem of the considered diffusion process through a fixed boundary.
The revised Healthy Purchase Index (r-HPI): a validated tool for exploring the nutritional quality of household food purchases
Authors: Perignon Marlène , Rollet Pascaline , Tharrey Marion , Recchia Daisy , Drogué Sophie , Caillavet France , Méjean Caroline , Darmon Nicole 
Published: August 2022

AbstractBackgroundThe Healthy Purchase Index (HPI) assesses the nutritional quality of food purchases (FP) from food group expenditure shares only. However, it was developed from the FP of a disadvantaged population.ObjectiveTo adapt and validate the HPI for a general population.MethodsFP were obtained from a representative sample of French households (Kantar WorldPanel) subdivided into two subsamples. The first sample (n = 4375) was used to adapt and validate the score; the second sample (n = 2188) was used to test external validity. The revised-HPI (r-HPI) includes 2 subscores: the diversity subscore and the quality subscore. Diversity subscore points were awarded when expenditure shares were above the 25th percentile for 5 food groups (“Fruits”, “Vegetables”, “Starches”, “Dairy”, “Meat, Fish and Eggs”). Regression models between the expenditure shares of each food group and the Mean Adequacy Ratio (MAR) and the Mean Excess Ratio (MER) of FP were used to select quality subscore components and define cut-offs for point allocation. Construct validity was assessed on the first sample using Spearman’s correlations between the r-HPI and the four nutritional quality indicators (NRF9.3, MAR, MER, energy density), and also by comparing the r-HPI of monthly FP of sub-populations defined by criteria known to influence diet quality (age, gender, income, education) and between households having a monthly food basket of higher (MAR > median and MER and energy density < median) vs. lower nutritional quality within the population, using Wilcoxon tests or pairwise comparisons of contrasts. External validity was tested by performing the same analyses on the 2nd sample of 2188 households.ResultsThe adaptation led to include new components (e.g. red meat) and define new cut-offs (e.g. − 1 point when budget share for red meat > 21%). The r-HPI (mean = 6.50 ± 3.58) was strongly correlated with NRF9.3, MAR, MER and energy density (0.59, 0.52, − 0.41 and − 0.65, respectively,p < 0.01) and poorly correlated with total energy content (− 0.096,p < 0.001). The r-HPI was significantly higher in women (β = 1.41 [0.20],p < 0.01), households having a food basket of higher nutritional quality (β = 4.15 [0.11],p < 0.001), and increased significantly with age, income and education levels. Similar results were obtained in the 2nd sample.ConclusionWe showed the validity of the r-HPI in a large sample of French households. As it does not require food quantity or nutrient content, it can be used as a valuable tool to explore FP behaviours. Cut-offs can be used in health promotion to provide nutri-economic counselling.
Theoretical psychology: discursive transformations and continuity in Psychological Research/Psychologische Forschung
Authors: Wendt Alexander Nicolai , Wolfradt Uwe 
Published: August 2022

AbstractPsychological Research (formerly Psychologische Forschung) has been published for a century which makes it a valuable subject matter for historical investigations. The journal’s development bears traces of the progress in psychology. This development is of particular interest for the field of theoretical psychology which investigates the epistemological and methodological background. Our hypothesis is that the history of Psychological Research is indicative for the transformations within the discourse of the discipline, i.e., the general context of communication in psychology. We revisit the changes in the editorial practises of the journal through a scientometric mixed-methods approach, combining bibliometric analyses which compare Psychological Research to Psychological Review and the British Journal of Psychology with a single-case investigation. Regarding form, we find continuities and disruptions in the development of the editorial customs from long and single-author to short and multi-author contributions. Investigating content through word frequency analysis shows that the journal’s history reflects the rise of the cognitivist paradigm as well as a transition from theoretical discourse towards experimentation. The analysis of a single case demonstrates the nature of past theoretical discourse in contrast to contemporary practises. Overall, our findings support the assumption of discursive transformations. From the perspective of theoretical psychology, these transformations can be described as a shift towards Methodism which entails a critical negligence of theory.
Deviating HER2 test results in gastric cancer: analysis from the prospective multicenter VARIANZ study
Authors: Kolbe Katharina , Haffner Ivonne , Schierle Katrin , Maier Dieter , Geier Birgitta , Luber Birgit , Bläker Hendrik , Wittekind Christian , Lordick Florian 
Published: August 2022

Abstract
Purpose
The prospective multicenter VARIANZ study aimed to identify resistance biomarkers for HER2-targeted treatment in advanced gastric and esophago-gastric junction cancer (GC, EGJC). HER2 test deviations were found in 90 (22.3%) of 404 cases (central versus local testing) and were associated with negative impact on survival for trastuzumab-treated patients. Here, we investigated methodological and biological variables that may promote deviating HER2 test results.

Methods
We analyzed HER2 testing procedures and participation in quality assurance programs of 105 participating local pathology laboratories. Furthermore, tumor localization and histological subtypes were compared between patients with centrally confirmed (central HER2 + /local HER2 + , n = 68) and unconfirmed HER2 status (central HER2 −/local HER2 + , n = 68).

Results
For central HER2 testing, concordance between in situ hybridization (ISH) and immunohistochemistry (IHC) was 98.3%, with IHC sensitivity of 93.3% (84 IHC + of 90 ISH +), specificity of 99.5% (389 IHC- of 391 ISH-), and a positive diagnosis rate of 97.7%. Central confirmation of the local HER2 IHC scores were seen for the majority of locally HER2- IHC 0/1 (172/178; 96.6%), but less frequently for locally IHC3 + (57/124; 46.0%) cases. Deviation rate was not associated with IHC antibody platform used in the local pathology institute neither with participation in quality-assuring tests. Regarding tumor characteristics, deviating test results were more frequently found in GC vs. EGJC (69.1% vs. 39.7%; p = 0.001) and in Laurén diffuse vs. intestinal subtype (23.5% vs. 5.9%, p = 0.004).

Conclusion
Tumor localization and histological subtype have an impact on HER2 test deviation rates. Assessment of HER2 remains challenging for GC and EGJC.