bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bird carcass detection from integrated trials at multiple wind farms
Authors: Kitano Masato , Smallwood K. Shawn , Fukaya Keiichi 
Published: November 2022

AbstractIt is often necessary to estimate the number of wind turbine collision fatalities to assess impacts to birds following construction of wind farms. Detection of bird carcasses at wind turbines in the field is affected by carcass persistence and searcher detection rate. Integrated detection trials, which integrate carcass persistence and searcher detection trials into the periodic fatality search, have been proposed as an effective method for estimating these parameters. The purpose of our study was to test whether and how environmental factors affect integrated detection trial outcomes at multiple wind farms. We conducted this study at 10 wind farms in various environments of Japan. Binary data on trial outcomes in open versus forested areas served as our response variable in a generalized additive mixed model informed by days into trial, carcass body mass, season, whether snow covered the ground, and precipitation. For both ground cover types, days into trial and body mass were included in all the top models, suggesting that these factors most influenced bird carcass detection probability in integrated trials. The best model in open areas included days into trial, body mass, snow, and precipitation, and the best model in forested areas included days into trial, body mass, snow, precipitation, and season. Values of area under the curve indicated high accuracy of the best model for both ground cover types. The survey design needs to be appropriate to the size of the target species and to the environment in which the impacts will occur, such as the site's seasonality, its ground cover, and whether snow will cover the ground. Frequency of post‐construction fatality monitoring should also be set cautiously, especially at wind farms located on small‐bird migration routes, at wind farms in open areas, in areas with snow‐covered ground in winter, or in forested areas during spring and summer because detection probabilities decline fastest under such conditions.
Extent of Surgery for Follicular Thyroid Carcinoma
Authors: Kethidi Nikhit , Vedula Sudeepti , Shihora Dhvani , Patel Rushi , Park Richard C. W. 
Published: November 2022

ObjectivesTo examine the association between the extent of surgery and overall survival in follicular thyroid cancer (FTC) patients.Study DesignRetrospective analysis of the National Cancer Database (NCDB).MethodsPatients who underwent surgical intervention for FTC from 2004 to 2015 were selected. Patients were >18 years old, with tumor size 1–4 cm, no other malignancies, and >0 follow up time. Patients were divided into two cohorts based on extent of surgery: lobectomy (≥1 lobe resected) and thyroidectomy (total or near total resection). Pearson's chi‐squared analysis was used to compare cohorts. Kaplan–Meier survival and Cox hazards models were utilized to determine overall survival between two cohorts with p < 0.05 used for significance.ResultsA total of 6871 patients were identified with FTC, of which 1507 patients underwent lobectomy and 5364 patients underwent total thyroidectomy. There were no significant differences in patient demographics, comorbidity index, local spread, or tumor grade. Patients undergoing lobectomy had mean survival of 12.94 versus 12.71 years for those undergoing thyroidectomy. Extent of surgery was not associated with a significant difference in survival (5 years OS = 96% in lobectomy and 95.5% in total thyroidectomy, p = 0.08). Stratification by tumor grade resulted in no significant difference in survival between lobectomy and thyroidectomy.ConclusionSurvival time was not significantly different in patients with more extensive resection of FTC.Level of Evidence3 Laryngoscope, 133:993–999, 2023
Are Mobile Applications in Laryngology Designed for All Patients?
Authors: Odigie Eseosa , Andreadis Katerina , Chandra Iyra , Mocchetti Valentina , Rives Hal , Cox Steven , Rameau Anaïs 
Published: November 2022

ObjectivesMobile applications (apps) are multiplying in laryngology, with little standardization of content, functionality, or accessibility. The purpose of this study is to evaluate the quality, functionality, health literacy, readability, accessibility, and inclusivity of laryngology mobile applications.MethodsOf the 3230 apps identified from the Apple and Google Play stores, 28 patient‐facing apps met inclusion criteria. Apps were evaluated using validated scales assessing quality and functionality: the Mobile App Rating Scale (MARS) and the Institute for Healthcare Informatics App Functionality Scale. The Clear Communication Index (CDC) Institute of Medicine Strategies for Creating Health Literate Mobile Applications, and Patient Education Materials Assessment Tool (PEMAT) were used to evaluate apps health literacy level. Readability was assessed using established readability formulas. Apps were evaluated for language, accessibility features, and representation of a diverse population.ResultsTwenty‐six apps (92%) had adequate quality (MARS score > 3). The mean PEMAT score was 89% for actionability and 86% for understandability. On average, apps utilized 25/33 health literate strategies. Twenty‐two apps (79%) did not pass the CDC index threshold of 90% for health literacy. Twenty‐four app descriptions (86%) were above an 8th grade reading level. Only 4 apps (14%) showed diverse representation, 3 (11%) had non‐English language functions, and 2 (7%) offered subtitles. Inter‐rater reliability for MARS was adequate (CA‐ICC = 0.715).ConclusionWhile most apps scored well in quality and functionality, many laryngology apps did not meet standards for health literacy. Most apps were written at a reading level above the national average, lacked accessibility features, and did not represent diverse populations. Laryngoscope, 133:1540–1549, 2023
Longitudinal Clinical and Biological Characteristics in Juvenile‐Onset Huntington's Disease
Authors: Schultz Jordan L. , Langbehn Douglas R. , Al‐Kaylani Hend M. , van der Plas Ellen , Koscik Timothy R. , Epping Eric A. , Espe‐Pfeifer Patricia B. , Martin Erin P. , Moser David J. , Magnotta Vincent A. , Nopoulos Peggy C. 
Published: November 2022

AbstractBackgroundJuvenile‐onset Huntington's disease (JOHD) is a rare form of Huntington's disease (HD) characterized by symptom onset before the age of 21 years. Observational data in this cohort is lacking.ObjectivesQuantify measures of disease progression for use in clinical trials of patients with JOHD.MethodsParticipants who received a motor diagnosis of HD before the age of 21 were included in the Kids‐JOHD study. The comparator group consisted of children and young adults who were at‐risk for inheriting the genetic mutation that causes HD, but who were found to have a CAG repeat in the non‐expanded range (gene non‐expanded [GNE]).ResultsData were obtained between March 17, 2006, and February 13, 2020. There were 26 JOHD participants and 78 GNE participants who were comparable on age (16.03 vs. 14.43, respectively) and sex (53.8% female vs. 57.7% female, respectively). The mean annualized decrease in striatal volume in the JOHD group was −3.99% compared to −0.06% in the GNE (mean difference [MD], −3.93%; 95% confidence intervals [CI], [−4.98 to −2.80], FDR < 0.0001). The mean increase in the Unified Huntington's Disease Rating Scale Total Motor Score per year in the JOHD group was 7.29 points compared to a mean decrease of −0.21 point in the GNE (MD, 7.5; 95% CI, [5.71–9.28], FDR < 0·0001).ConclusionsThese findings demonstrate that structural brain imaging and clinical measures in JOHD may be potential biomarkers of disease progression for use in clinical trials. Collaborative efforts are required to validate these results in a larger cohort of patients with JOHD. © 2022 International Parkinson and Movement Disorder Society.
Validation of a modified bedside Pediatric Early Warning System score for detection of clinical deterioration in hospitalized pediatric oncology patients: A prospective cohort study
Authors: Soeteman Marijn , Kappen Teus H. , van Engelen Martine , Marcelis Maartje , Kilsdonk Ellen , van den Heuvel‐Eibrink Marry M. , Nieuwenhuis Edward E. S. , Tissing Wim J. E. , Fiocco Marta , van Asperen Roelie M. Wösten‐ 
Published: November 2022

AbstractBackgroundHospitalized pediatric oncology patients are at risk of severe clinical deterioration. Yet Pediatric Early Warning System (PEWS) scores have not been prospectively validated in these patients. We aimed to determine the predictive performance of the modified BedsidePEWS score for unplanned pediatric intensive care unit (PICU) admission and cardiopulmonary resuscitation (CPR) in this patient population.MethodsWe performed a prospective cohort study in an 80‐bed pediatric oncology hospital in the Netherlands, where care has been nationally centralized. All hospitalized pediatric oncology patients aged 0–18 years were eligible for inclusion. A Cox proportional hazard model was estimated to study the association between BedsidePEWS score and unplanned PICU admissions or CPR. The predictive performance of the model was internally validated by bootstrapping.ResultsA total of 1137 patients were included. During the study, 103 patients experienced 127 unplanned PICU admissions and three CPRs. The hazard ratio for unplanned PICU admission or CPR was 1.65 (95% confidence interval [CI]: 1.59–1.72) for each point increase in the modified BedsidePEWS score. The discriminative ability was moderate (D‐index close to 0 and a C‐index of 0.83 [95% CI: 0.79–0.90]). Positive and negative predictive values of modified BedsidePEWS score at the widely used cutoff of 8, at which escalation of care is required, were 1.4% and 99.9%, respectively.ConclusionThe modified BedsidePEWS score is significantly associated with requirement of PICU transfer or CPR. In pediatric oncology patients, this PEWS score may aid in clinical decision‐making for timing of PICU transfer.
A congenital CSF3R mutation in chronic neutropenia reveals a vital role for a cytokine receptor extracellular hinge motif in the response to granulocyte colony‐stimulating factor
Authors: Feyen Jacqueline , Ernst Martijn P. T. , van der Velden Vincent H. J. , Valk Peter J. M. , Broeders Lianne , Touw Ivo P. , Raaijmakers Marc H. G. P. 
Published: November 2022

AbstractWe describe a patient with congenital neutropenia (CN) with a homozygous germline mutation in the colony‐stimulating factor 3 receptor gene (CSF3R). The patient's bone marrow shows lagging neutrophil development with subtle left shift and unresponsiveness to CSF3 in in vitro colony assays. This patient illustrates that the di‐proline hinge motif in the extracellular cytokine receptor homology domain of CSF3R is critical for adequate neutrophil production, but dispensable for in vivo terminal neutrophil maturation. This report underscores that CN patients with inherited CSF3R mutations should be marked as a separate clinical entity, characterized by a failure to respond to CSF3.
Effects of COVID‐19 vaccination on platelet counts and bleeding in children, adolescents, and young adults with immune thrombocytopenia
Authors: Kaicker Shipra , Martinko Kirsten , Bussel James B. 
Published: November 2022

AbstractCoronavirus disease 2019 (COVID‐19) vaccines rarely cause de novo immune thrombocytopenia (ITP) but may worsen preexisting ITP in adults. Whether severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines impact platelet counts and bleeding in children, adolescents, and young adults (C‐AYA) with preexisting ITP is unknown. We report here the very limited effect of COVID‐19 vaccination on platelet counts and bleeding in a single‐center series of 2 C‐AYA with ITP. No patient experienced worsening bleeding and only one child had a significant decrease in platelet count which improved spontaneously to her baseline without intervention. SARS‐CoV2 vaccination was safe in C‐AYA with ITP in this small cohort.
Effect of a novel pilot support group on distress and quality of life in breast cancer patients in Nigeria
Authors: Asuzu Chioma C. , Akin‐Odanye Elizabeth O. , Asuzu Michael C. , Adedokun Tunde , Ntekem Atara , Ogundiran Temidayo , Henry Mellissa , Watson Maggie 
Published: November 2022

AbstractObjectiveTo assess the effect of a new breast cancer support group (BCSG) on breast cancer patients' self‐reported distress and quality of life.MethodsA single arm pre‐post trial providing an eight session healthcare provider led BCSG. Primary outcome variables were distress and quality of life assessed using the National Comprehensive Cancer Network Distress Thermometer (DT) and The Functional Assessment of Cancer Therapy ‐ Breast plus Arm Morbidity (FACT‐B+4), respectively. Topics in each session addressed a wide range of issues some of which were pre‐selected by the patients themselves.Data analysisPaired sample t‐test was used for data analysis on International Business Machine Statistical Package for the Social Sciences 21.ResultsThe participants (N = 18) had a mean age of 51. Most had secondary school level education (54%), were traders (59%) and had stage 3 or 4 disease (67%). A larger proportion (78% or n = 14) of the patients lived in rural areas, while 4 (22%) of the patients lived in Ibadan. Out of the 8 sessions, 12 (67%) of the participants attended 1‐3 sessions while 6 (33%) attended 4‐8 sessions. There were, significant improvements in emotional wellbeing (t = −4.253; p < 0.05) and functional wellbeing (t = −2.191; p < 0.05) on the FACT‐B+4. There was a significant reduction in the DT score (t = 2.345; p < 0.05) but the number of items on the problem list were not significantly reduced (t = 1.191; p > 0.05). Majority (75%) of the patients rated the support group activities as satisfactory.ConclusionThese data show that the support group can benefit breast cancer patients in terms of reduced distress levels along with satisfaction and improvement in the functional and emotional wellbeing indices of quality of life.
Use of group IIB metal ions as charge carriers for collision‐induced dissociation of glycopeptide and glycan
Authors: Wong H.‐T. Kitty , Chen Xiangfeng , Zhang Simin , Lui Tin‐Yi , Hu Danna , Chan T.‐W. Dominic 
Published: November 2022

RationaleDissociation of biomolecules by tandem mass spectrometry (MS/MS) generates a variety of fragment ions which provide useful information for the structural characterization of biomolecules. Different fragmentation strategies result in different mass spectra for the same molecule and thus provide distinct features. Charge carriers play important roles in determining the dissociation pathways of the target precursor ions. The use of various transition metals ions as charge carriers of glycopeptide and glycan might provide additional structural information and needs to be investigated.MethodsA 9.4 T SolariX FTICR mass spectrometer was used for collision‐induced dissociation (CID) of glycopeptide and glycan. Group IIB metal ions, including Zn2+, Cd2+ and Hg2+, were used as charge carriers. Glycopeptide NLTK‐M5G2 and glycan G1F were used as the model systems.ResultsFor Zn2+‐ and Cd2+‐adducted species, cross‐ring cleavages, glycosidic cleavages and cleavages along the peptide backbone could be obtained. There is a high degree of similarity in their CID spectra with that of Mg2+ ion‐adducted glycopeptide species. For Hg2+‐adducted species, only glycosidic cleavages were observed in high abundance. The formation of doubly‐charged ions (M2+) and a series of [f−H]+ fragments indicated unique dissociation pathways for Hg2+‐adducted glycopeptide.ConclusionsZn2+ and Cd2+‐adducted glycopeptide species produced similar dissociation CID spectra, whereas Hg2+‐adducted species produced significantly different CID spectra. Similar CID dissociation features were also observed for Group IIB metal ions adducted glycan species. These results demonstrated that different metal ions might be used to tune the dissociation behaviors of glycopeptides and glycans.
Estimation and prediction of ecological footprint using tourism development indices top tourist destination countries
Authors: Roumiani Ahmad , Basir Arian Abdul , Mahmoodi Hamide , Shayan Hamid 
Published: November 2022

AbstractDuring the last two decades, the ecological footprint (EF) has had various fluctuations and has been associated with an upward trend, which can be a concern. This research aims to statistically examine tourism development indices and their effect on the EF during the last two decades in eight top tourism countries (France, United States, China, Italy, Turkey, Mexico, Thailand, and Germany). For this purpose, indices (extracted from the World Bank and Global Footprint Network databases) were used. Also, repeatability models were used to check the time and place and penalized regression models were used for the fit and accuracy of tourism development indices. The research findings showed that the amount of EF in the countries of China, France, the United States of America, Mexico and Thailand had an upward trend. The predictive accuracy of the penalized regression models of Ridge, LASSO and Elastic Net were reported as 0.910, 0.908, and 0.908, respectively. The difference is that the LASSO model acted more strictly and provided a more economical model by selecting the variable. We believe that a deeper statistical look can effectively apply an efficient strategy in better management of the EF challenge.
Clinical utility of a new protocol of cardiac computed tomography in dogs
Authors: Kim Junyoung , Lee Siheon , Hwang Jeongyeon , Yoon Junghee 
Published: November 2022

AbstractObjectivesThe characteristics of non‐electrocardiography‐ and electrocardiography‐gated multidetector computed tomography have not been extensively studied in veterinary clinics but it can be useful for cardiac imaging. This study aimed to ascertain the differences between non‐electrocardiography and electrocardiography gating methods and to establish their clinical utility based on patient history.MethodsSix client‐owned dogs (two with patent ductus arteriosus, two with heart base tumour, one with pericardial mesothelioma, and one with normal health) were included in this study. All the dogs were examined using a non‐electrocardiography‐gated scan, followed by a retrospective electrocardiography‐gated scan. Images were reviewed to determine the optimal scan timing and R–R interval in non‐electrocardiography‐ and electrocardiography‐gated images, respectively, for detailed coronary artery imaging, diagnostic quality of the best coronary artery visualisation in non‐electrocardiography‐ and electrocardiography‐gated images through visual assessment of the main coronary artery branches, and branching patterns of the left coronary artery. Further, we compared the size and margin demarcation of the heart or pericardial lesions in non‐electrocardiography‐ and electrocardiography‐gated images obtained from patients with heart or pericardial tumours.ResultsThe optimal scan timing and R–R interval were the second‐scan timing and end‐diastole (70%–90%), respectively. Second‐scan non‐electrocardiography‐gated images allowed coronary artery evaluation, indicating high‐grade quality in visual assessment, except for the septal branch. Electrocardiography‐gated images, but not non‐ECG‐gated images, clearly revealed pericardial nodules in two dogs.Clinical SignificanceOur findings suggest the respective clinical utilities of non‐electrocardiography‐ or electrocardiography‐gated imaging using high‐slice cardiac computed tomography based on patient history.
Qualitative inquiry in leadership development: An overview for practitioner‐scholars
Authors: Kniffin Lori E. , Priest Kerry 
Published: November 2022

AbstractThis article serves as an overview of qualitative inquiry for leadership development practitioner‐scholars both new and experienced. It begins with a discussion of the need for the qualitative inquiry to create knowledge about leadership development. Then, it overviews design components and includes examples of both research and assessment. We conclude by discussing quality standards for qualitative inquiry and providing suggestions for future directions.
Don't be afraid to eat the whole whale! Using mixed methods to enhance what we learn in leadership research and assessment
Authors: Hastings Lindsay J. 
Published: November 2022

AbstractThe purpose of this article is to identify proper uses for mixed methods in leadership research and assessment. This article will highlight research and assessment questions that are best served by mixed methods and will offer practitioner‐friendly guides and examples for integrating quantitative and qualitative data to help eat the whole whale “one bite at a time.” Sound decision‐making in the design, execution, and presentation of mixed methods studies and outcomes assessments not only produces better outputs, but greatly increases the likelihood of (a) publication in reputable journals, (b) sound program evaluation decisions, and (c) public consumption of study or assessment results.
Phase information in cosmological collider signals
Authors: Qin Zhehan , Xianyu Zhong-Zhi 
Published: November 2022

Abstract
Massive particles produced during the cosmic inflation can imprint in the primordial non-Gaussianities as characteristic oscillating functions of various momentum ratios, known as cosmological collider signals. We initiate a study of the phase of the oscillating signals which can be unambiguously defined and measured. The phase can provide useful new information about the spin and the couplings of the intermediate heavy particles that cannot be obtained from the signal frequency and angular dependences alone. We also present new analytical results for full nonlocal signals from two typical 1-loop processes, enabling precise determination of the signal phase away from the squeezed limit.
Small Extracellular Vesicles Loaded with Immunosuppressive miRNAs Leads to an Inhibition of Dendritic Cell Maturation
Authors: Czernek Liliana , Pęczek Łukasz , Düchler Markus 
Published: November 2022

AbstractIn particular conditions, inhibition of an immune response is required to prevent tissue damage. Among these conditions are diseases caused by an over-reactive immune response, such as autoimmune or allergic disorders, or imminent organ rejection after transplantation. To avoid tissue damage, drug-mediated systemic immune suppression is an option, but it comes with high costs in the form of susceptibility to viral and bacterial infections. Thus, the induction of antigen-specific tolerance is preferable. Extracellular vesicles (EVs) are capable of delivering antigen together with immunosuppressive signals and may be used to specifically induce antigen-specific tolerance. However, naturally occurring EVs are heterogeneous and not all of them show immunosuppressive character. In our trials to engineer cell culture derived EVs to increase their tolerogenic potential, we equipped them with immunosuppressive miRNA mimics. Small EVs (sEVs) were isolated and purified from the human monocytic THP-1 cell line or from healthy donor peripheral blood mononuclear cells, and electroporated with miR-494 and miR-146a mimics. The acquired immunosuppressive potential of the modified sEVs was demonstrated by their ability to alter the major histocompatibility complex molecules and co-stimulatory receptors present on dendritic cells (DCs). To avoid allogeneic responses, the same cells that produced the sEVs served also as recipient cells. In contrast to the treatment with unmodified sEVs, the tolerogenic sEVs impeded lipopolysaccharide-induced maturation and kept DCs in a more immature developmental stage. Our experiments show that simple manipulations of sEVs using immunosuppressive cargo can lead to the inhibition of DC maturation.