bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed-effect models with trees
Authors: Gottard Anna , Vannucci Giulia , Grilli Leonardo , Rampichini Carla 
Published: July 2022

AbstractTree-based regression models are a class of statistical models for predicting continuous response variables when the shape of the regression function is unknown. They naturally take into account both non-linearities and interactions. However, they struggle with linear and quasi-linear effects and assume iid data. This article proposes two new algorithms for jointly estimating an interpretable predictive mixed-effect model with two components: a linear part, capturing the main effects, and a non-parametric component consisting of three trees for capturing non-linearities and interactions among individual-level predictors, among cluster-level predictors or cross-level. The first proposed algorithm focuses on prediction. The second one is an extension which implements a post-selection inference strategy to provide valid inference. The performance of the two algorithms is validated via Monte Carlo studies. An application on INVALSI data illustrates the potentiality of the proposed approach.
The association between coronary artery disease and osteoporosis: a population-based longitudinal study in Taiwan
Authors: Syu De-Kai , Hsu Shu-Hua , Yeh Ping-Chun , Kuo Yu-Feng , Huang Yen-Chun , Jiang Ching-Chuan , Chen Mingchih 
Published: July 2022

Abstract
Purpose
This large population-based study is the first to analyze the association between coronary artery disease (CAD) and osteoporosis (OP) from the National Health Insurance Research Database (NHIRD) in Taiwan to determine if CAD is associated with OP.

Methods
Data from NHIRD, a national, population-based, retrospective, matched cohort study of 23 million patients, were collected to recruit two matched cohorts: with (n = 192,367) and without (n = 192,367) CAD. The Cox model was used to compare the incidence rate ratio and crude hazard ratio (HR) between the two cohorts for osteoporotic fracture and OP.

Results
The CAD cohort had a significantly increased risk for vertebral compression fracture, with an adjusted HR of 1.74 (95% CI, 1.60–1.89). The cumulative incidence of OP was also statistically higher in the cohort versus without CAD (11.6% vs. 5.6%; p ≤ 0.0001, log-rank) during the 10-year follow-up period. The Cox model showed a 2.04-fold increase in the incidence of OP in the CAD cohort, with an adjusted HR of 2.04 (95% confidence interval [CI], 1.99–2.08).

Conclusions
A positive association exists between CAD and development of subsequent osteoporotic fracture and OP. Patients with CAD have a significantly increased risk of developing vertebral compression fracture and a higher incident rate ratio of OP.

Trial registration
IRB approval number: No. C108094 on February 19, 2020.
Barriers to accessing aeroallergen immunotherapy in paediatrics
Authors: Trayer James , Byrne Aideen , Elnazir Basil 
Published: July 2022

AbstractBackgroundAllergen immunotherapy (AIT) is a safe, effective and disease-modifying treatment for allergic rhinitis. It is indicated for children with moderate to severe disease whose symptoms persist despite conventional therapy. There is a high prevalence of allergic rhinitis amongst Irish children; however, levels of AIT prescribing in Ireland are lower than neighbouring countries.AimsThe aims of this study are to describe current patterns of AIT prescribing and referrals amongst Irish paediatricians and to identify barriers to accessing AIT in Ireland.MethodsAn electronic questionnaire was distributed to all paediatricians and paediatric trainees caring for children with allergic rhinitis.ResultsA lack of knowledge of AIT clinical criteria was the most frequently reported barrier with 50.5% (50/99) of general paediatricians unaware of the indications for referral compared to 27.3% (3/11) of respiratory physicians and 0% (0/8) of allergists. Accessibility is the next most cited barrier with 31.4% (37/118) of respondents unsure where to refer and 19.5% (23/118) reporting a lack of local services. Cost was reported to be a barrier by 12.7% (15/118). Paediatricians with an allergy or respiratory subspecialisation reported seeing significantly higher numbers of children with allergic rhinitis and were more likely to prescribe or refer a child for AIT.ConclusionsThis study demonstrated positive attitudes towards AIT amongst all grades and specialities of paediatricians in Ireland. The main barriers to more widespread use are difficulties with the identification of suitable candidates by general paediatricians and a lack of local AIT services and referral pathways.
Hospital mortality and length of stay differences in emergency medical admissions related to ‘on-call’ specialty
Authors: Conway Richard P. , Byrne Declan G. , O’Riordan Deirdre M. R. , Silke Bernard 
Published: July 2022

Abstract
Background
The outcomes of acute medical admissions have been shown to be influenced by a variety of factors including system, patient, societal, and physician-specific differences.

Aim
To evaluate the influence of on-call specialty on outcomes in acute medical admissions.

Methods
All acute medical admissions to our institution from 2015 to 2020 were evaluated. Admissions were grouped based on admitting specialty. Thirty-day in-hospital mortality and length of stay (LOS) were evaluated. Data was analysed using multivariable logistic regression and truncated Poisson regression modelling.

Results
There were 50,347 admissions in 30,228 patients. The majority of admissions were under Acute Medicine (47.0%), and major medical subspecialties (36.1%); Elderly Care admitted 12.1%. Acute Medicine admissions were older at 72.9 years (IQR 57.0, 82.9) vs. 67.2 years (IQR 50.1, 80.2), had higher Acute Illness Severity (grades 4–6: 85.9% vs. 81.3%; p < 0.001), Charlson Index (> group 0; 61.5% vs. 54.6%; p < 0.001), and Comorbidity Score (40.7% vs. 36.7%; p < 0.001). Over time, there was a small (+ 8%) but significant increase in 30-day in-hospital mortality. Mortality rates for Acute Medicine, major medical specialties, and Elderly Care were not different at 5.1% (95% CI: 4.7, 5.5), 4.7% (95% CI: 4.3, 5.1), and 4.7% (95% CI: 3.9, 5.4), respectively. Elderly Care admissions had shorter LOS (7.8 days (95% CI: 7.6, 8.0)) compared with either Acute Medicine (8.7 days (95% CI: 8.6, 8.8)) or major medical specialties (8.7 days (95% CI: 8.6, 8.9)).

Conclusion
No difference in mortality and minor differences in LOS were observed. The prior pattern of improved outcomes year on year for emergency medical admissions appears ended.
Mobile money for women’s economic empowerment: the mediating role of financial management practices
Authors: Dorfleitner Gregor , Nguyen Quynh Anh 
Published: July 2022

AbstractThis article examines whether mobile money adoption contributes to women’s economic empowerment, and considers the mediating effect of financial management behavior. Cross-sectional data analysis is conducted utilizing a sample of women in seven countries across South Asia and Sub-Saharan Africa. We also investigate whether these effects vary between rural and urban areas. Three measures of mobile money adoption are considered to reflect the process of engaging in mobile money services. We find supportive evidence for the impact of mobile money adoption on women’s economic empowerment and the influencing mechanism of financial management behavior for the whole sample and the rural sub-sample. Moreover, the results are consistent for three alternative measures of mobile money adoption. Our findings suggest that mobile money can be harnessed to promote women’s economic empowerment; however, the impact appears to be greater if women are equipped with proper financial management skills.
Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity
Authors: Shadfar Sina , Khanal Shristi , Bohara Ganesh , Kim Geumjin , Sadigh-Eteghad Saeed , Ghavami Saeid , Choi Hyukjae , Choi Dong-Young 
Published: July 2022

Abstract
Boswellia serrata gum is a natural product that showed beneficial effects on neurodegenerative diseases in recent studies. In this study, we investigated the effects of Boswellia serrata resin on rotenone-induced dopaminergic neurotoxicity. Firstly, we attempted to see if the resin can induce AMP-activated protein kinase (AMPK) signaling pathway which has been known to have broad neuroprotective effects. Boswellia increased AMPK phosphorylation and reduced phosphorylation of mammalian target of rapamycin (p-mTOR) and α-synuclein (p-α-synuclein) in the striatum while increased the expression level of Beclin1, a marker for autophagy and brain-derived neurotrophic factor. Next, we examined the neuroprotective effects of the Boswellia extract in the rotenone-injected mice. The results showed that Boswellia evidently attenuated the loss of the nigrostriatal dopaminergic neurons and microglial activation caused by rotenone. Moreover, Boswellia ameliorated rotenone-induced decrease in the striatal dopamine and impairment in motor function. Accumulation of α-synuclein meditated by rotenone was significantly ameliorated by Boswellia. Also, we showed that β-boswellic acid, the active constituents of Boswellia serrata gum, induced AMPK phosphorylation and attenuated α-synuclein phosphorylation in SHSY5 cells. These results suggest that Boswellia protected the dopaminergic neurons from rotenone neurotoxicity via activation of the AMPK pathway which might be associated with attenuation of α-synuclein aggregation and neuroinflammation. Further investigations are warranted to identify specific molecules in Boswellia which are responsible for the neuroprotection.
Modelling road cycling as motion on a curve
Authors: Nee P. J. , Herterich J. G. 
Published: July 2022

AbstractWe present a mathematical model of road cycling on arbitrary routes using the Frenet–Serret frame. The route is embedded in the coupled governing equations. We describe the mathematical model and numerical implementation. The dynamics are governed by a balance of forces of gravity, drag, and friction, along with pedalling or braking. We analyse steady-state speed and power against gradient and curvature. The centripetal acceleration is used as a control to determine transitions between pedalling and braking. In our model, the rider looks ahead at the curvature of the road by a distance dependent on the current speed. We determine such a distance (1–3 s at current speed) for safe riding and compare with the mean power. The results are based on a number of routes including flat and downhill, with variations in maximum curvature, and differing number of bends. We find the braking required to minimise centripetal acceleration occurs before the point of maximum curvature, thereby allowing acceleration by pedalling out of a bend.
Uncovering the identity of Electronic Markets research through text mining techniques
Authors: Nahr Nora , Heikkilä Marikka 
Published: July 2022

Abstract

As an established academic journal in the e-commerce and digital platforms fields, Electronic Markets (EM) features a diverse range of topics and occupies a significant role in the information systems field. The study investigates EM’s topic diversity over the time period 2009–2020 using a text mining analysis and a bibliometric analysis and identifies 28 cluster groups. The analysis reveals that the top three topics are 1) service quality, 2) blockchain and other shared trust building solutions, their impact and credibility, as well as 3) consumer buying behavior and interactions. EM's core identity lies in a balanced set of core themes that bring technological, business or human/ social perspectives to the research of networked business and digital economy. This includes research on digital and smart services, applications, consumer behavior and business models, as well as technology and e-commerce data. Ethical and sustainability related topics are however still less present in EM.
Ipsilateral Cervicodeltopectoral Flap: A Forgotten Technique, Revival in the Era of Microvascular Reconstruction
Authors: Usman Nawaz , Dikhit Punit Singh , Kumar Naveena A. N. , Shetty Preethi S. , Rajan Keshava , Vittamsetti V. N. R. , Dinker Diksha , Jose Anmi 
Published: July 2022

AbstractOral cavity cancer is one of the most common cancers in India responsible for significant morbidity and mortality in Indian subcontinent. Majority of cases present in advanced stages which requires extensive reconstruction following tumor resection. Microvascular free flap reconstruction is now considered standard of care for reconstruction for major head and neck skin-mucosal defects but, many factors still act as hindrance like patient’s comorbidities, long operating hours for microvascular reconstruction, logistic and financial issues from patient’s side. In such situation it is better to have a backup plan for reconstruction of major head and neck defects using pedicled flaps. Pectoralis major myocutaneous (PMMC) flap has been the workhorse flap for head and neck reconstruction since its introduction four decades ago. But relying too much on PMMC flap for major skin-mucosal defects especially in female patients is associated with complications and risk for flap failure leading to catastrophic and significant patient morbidities. Our study involves the use of two flaps for head and neck reconstuction involving skin-mucosal defects i.e PMMC flap for mucosal defect and cervicodeltopectoral (CDP) flap for skin defect. As of now there has been no retrospective or prospective study done which has given a conclusive statement regarding use of these two flaps simultaneously for head and neck reconstruction to the best of our knowledge. In our experience from the present study, CDP flap offers an excellent alternative for extensive head and neck reconstruction and can be readily included in the surgeon’s armamentarium with proper planning and meticulous handling.
Folic Acid Determination in Food Samples Using Green Synthesized Copper Oxide Nanoparticles and Electro-Poly (Methyl Orange) Sensor
Authors: Hasan Ibrahem M. A. , Abd-Elsabur Keriman M. , Assaf Fawzy H. , Abd-Elsabour Mohamed 
Published: July 2022

AbstractCopper (II) oxide nanoparticles (CuONPs) were green synthesized using Ocimum basilicum leaves aqueous extract in which polyphenols act as reducing and stabilizing agents. The synthesized CuONPs were characterized using X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, selected area electron diffraction, and Brunauer–Emmett–Teller (BET) surface area analysis. The analyses indicated the formation of crystalline rod-like monoclinic pure CuONPs with a mean grain size of 15 nm, a surface area of 396 m2 g−1, and a total pore volume of 0.71 cm3 g−1. A glassy carbon electrode (GCE) was modified using the synthesized CuONPs and electropolymerized poly(methyl orange) (PMO). The modified PMO/CuONPs/GCE electrode was electrochemically characterized and applied for the estimation of folic acid (FA) by cyclic voltammetry, chronoamperometry, linear sweep voltammetry, and differential pulse voltammetry techniques. The influence of pH (7), scan rate (50 mV/s), supporting electrolyte (0.1 M KCl) and FA concentration has been optimized. FA is precisely determined in the range from 0.01 to 1.5 µΜ with a low detection limit (0.002 µΜ), a low quantitation limit (0.068 µΜ), high reproducibility (RSD 0.37, 10 measurements), and high stability (98% activity after 50 days). FA in food samples was determined by the new sensor with high recoveries from 93 to 108.8%.Graphical Abstract
Anti-prostate cancer protection and therapy in the framework of predictive, preventive and personalised medicine — comprehensive effects of phytochemicals in primary, secondary and tertiary care
Authors: Mazurakova Alena , Samec Marek , Koklesova Lenka , Biringer Kamil , Kudela Erik , Al-Ishaq Raghad Khalid , Pec Martin , Giordano Frank A. , Büsselberg Dietrich , Kubatka Peter , Golubnitschaja Olga 
Published: July 2022

AbstractAccording to the GLOBOCAN 2020, prostate cancer (PCa) is the most often diagnosed male cancer in 112 countries and the leading cancer-related death in 48 countries. Moreover, PCa incidence permanently increases in adolescents and young adults. Also, the rates of metastasising PCa continuously grow up in young populations. Corresponding socio-economic burden is enormous: PCa treatment costs increase more rapidly than for any other cancer. In order to reverse current trends in exploding PCa cases and treatment costs, pragmatic decisions should be made, in favour of advanced populational screening programmes and effective anti-PCa protection at the level of the health-to-disease transition (sub-optimal health conditions) demonstrating the highest cost-efficacy of treatments. For doing this, the paradigm change from reactive treatments of the clinically manifested PCa to the predictive approach and personalised prevention is essential.Phytochemicals are associated with potent anti-cancer activity targeting each stage of carcinogenesis including cell apoptosis and proliferation, cancer invasiveness and metastatic disease. For example, their positive effects are demonstrated for stabilising and restoring mitochondrial health quality, which if compromised is strongly associated with sub-optimal health conditions and strong predisposition to aggressive PCa sub-types. Further, phytochemicals significantly enhance response of cancer cells to anti-cancer therapies including radio- and chemotherapy. Evident plant-based mitigation of negative side-effects frequently observed for conventional anti-cancer therapies has been reported. Finally, dual anti-cancer and anti-viral effects of phytochemicals such as these of silibinin have been demonstrated as being highly relevant for improved PCa management at the level of secondary and tertiary care, for example, under pandemic conditions, since PCa-affected individuals per evidence are highly vulnerable towards COVID-19 infection.Here, we present a comprehensive data analysis towards clinically relevant anti-cancer effects of phytochemicals to be considered for personalised anti-PCa protection in primary care as well as for an advanced disease management at the level of secondary and tertiary care in the framework of predictive, preventive and personalised medicine.
First Italian report of a liver abscess and metastatic endogenous endophthalmitis caused by ST-23 hypervirulent Klebsiella pneumoniae in an immunocompetent individual
Authors: De Francesco Maria A. , Tiecco Giorgio , Scaltriti Erika , Piccinelli Giorgio , Corbellini Silvia , Gurrieri Francesca , Crosato Verena , Moioli Giovanni , Marchese Valentina , Focà Emanuele , Bertelli Davide A. , Castelli Francesco , Caruso Arnaldo 
Published: July 2022

Abstract
Background
Klebsiella pneumoniae is a common species in the gut of mammals and is widely distributed in the environment. However, the environmental source of hvKp that precedes gut colonization is unclear, but once that it reaches the gut there is a possible generalized spread y fecal-oral transmission especially in endemic areas. Liver abscess might develop when the bacteria, using its virulence factors, cross the intestinal barrier and invade the liver by the portal circulation. This syndrome, prevalent mostly in Asian countries, is increasingly reported in Western Countries and leaves open questions about the source of infection.

Case
Here we describe for the first time in Italy, a case of pyogenic liver abscess caused by a hypervirulent Klebsiella pneumoniae (HvKp) complicated by endophthalmitis and other metastatic infections in lung and prostate in an immunocompetent Chinese healthy individual with no recent travel in Asia.

Conclusion
This case underlines the need for increased awareness of hypervirulent K. pneumoniae, even in settings where it occurs infrequently and where there are not evident epidemiological links.
Die Biomarker TIMP-2 und IGFBP7 in der Diagnostik der Niereninsuffizienz
Authors: Oremek G. M. , Passek K. , von der Eltz V. , Dröge J. , Bendels M. 
Published: July 2022

ZusammenfassungDie vorliegende Übersicht über die Biomarkern TIMP‑2 („tissue inhibitor of metalloprokinase 2“) und IGFBP7 („insulin-like growth factor binding protein 7“) wird im Rahmen der Serie „Biomarker“ des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert. Die Marker TIMP‑2 und IGFBP7 eignen sich zur Abschätzung der Nierenschädigung und zur frühen Diagnostik der akuten Niereninsuffizienz. Hier zeigen diese eine hohe Sensitivität und Spezifität.
External Acoustical Damping on a Metallic Angle Wedge in a High Temperature Resistant Ultrasonic Probe
Authors: Shapovalov Oleg , Heckel Thomas , Gaal Mate , Weiß Sabine 
Published: July 2022

AbstractUltrasonic probes for high-temperature applications are provided with metallic wedges, which can withstand the contact with the high temperature of the inspected structure. The ultrasonic signal travels within the wedge and gets reflected from its boundaries, causing interference signals called “ghost echoes”. The current work presents an investigation of the additional damping effect provided by porous sintered metal plates applied onto the surface of the wedge. In particular, the study evaluates the effect of damping plate thickness on the interference signal level at different transmission frequencies. Damping plates made of sintered metal SIKA-R 15 AX were attached to a wedge prototype made of steel 1.4301. The study revealed, that the most effective thickness of damping plates in the selected frequency interval of 1 to 4 MHz is equal to 4 mm. The evaluation of the interference signal has shown that the application of such damping plates to the wedge surface contributes to an additional attenuation of an interference signal of 10 to 30 dB after 500 µs of signal propagation.
The Hilbert modular group and orthogonal groups
Authors: Hauffe-Waschbüsch Adrian , Krieg Aloys 
Published: July 2022

AbstractWe derive an explicit isomorphism between the Hilbert modular group and certain congruence subgroups on the one hand and particular subgroups of the special orthogonal groupSO(2, 2) on the other hand. The proof is based on an application of linear algebra adapted to number theoretical needs.