bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of corona poling on ZnO properties as n-type layer for optoelectronic devices
Authors: Magdy A. , El-Shaer A. , EL-Farrash A. H. , Salim E. 
Published: December 2022

AbstractCorona poling effects on optical and structural characteristics of zinc oxide (ZnO) thin films prepared by sol–gel spin coating technique were investigated. Atomic force microscope study showed the formation of pyramidal grains structure on the Corona-treated surface. The green–yellow photoluminescence peak centered at 2.36 eV and correlated to the antisite oxygen OZn defect, was found to decrease. X-ray diffraction patterns demonstrated that the Corona treatment enhanced the polycrystalline nature and increased the grain sizes of the ZnO thin films, which was also beneficial for electron transport. The role of the surface roughness of the ZnO thin film as electron transport layer in determining the photovoltaic effect of the inverted solar cells (ISCs) was examined by fabricating ISCs based on P3HT/PC61BM. The power conversion efficiency (PCE) obtained from these fabricated ISCs increased from 3.05 to 3.34%.
Traffic accident duration prediction using text mining and ensemble learning on expressways
Authors: Chen Jiaona , Tao Weijun 
Published: December 2022

AbstractPredicting traffic accident duration is necessary for ensuring traffic safety. Several attempts have been made to achieve high prediction accuracy, but researchers have not considered traffic accident text data in much detail. The limited text data of the first report on an incident describes the characteristics of an accident that are initially available. This paper uses text data fusing and ensemble learning algorithms to build a model to predict an accident’s duration, and a preprocessing scheme of accident duration text data is established. Next, the random forest (RF) algorithm is applied to select feature variables of text data related to the traffic incident duration. Last, a text feature vector is introduced to models such as decision tree, k nearest neighbor, support vector regression, random forest, Gradient Boosting Decision Tree, and Xtreme Gradient Boosting. Our results show that the improved RF model has good prediction accuracy with RMSE, MAPE and R2. From this, the textual factors important to determining the duration of the accident are identified. Further, we investigated that the cumulative importance of 60% is sufficient for traffic accident prediction using text data. These results provide insights into minimizing traffic congestion related to accidents and contribute to the input optimization in text prediction.
Congruence-based contextual plausibility modulates cortical activity during vibrotactile perception in virtual multisensory environments
Authors: Kang Kathleen , Rosenkranz Robert , Karan Kaan , Altinsoy Ercan , Li Shu-Chen 
Published: December 2022

AbstractHow congruence cues and congruence-based expectations may together shape perception in virtual reality (VR) still need to be unravelled. We linked the concept of plausibility used in VR research with congruence-based modulation by assessing brain responses while participants experienced vehicle riding experiences in VR scenarios. Perceptual plausibility was manipulated by sensory congruence, with multisensory stimulations confirming with common expectations of road scenes being plausible. We hypothesized that plausible scenarios would elicit greater cortical responses. The results showed that: (i) vibrotactile stimulations at expected intensities, given embedded audio-visual information, engaged greater cortical activities in frontal and sensorimotor regions; (ii) weaker plausible stimulations resulted in greater responses in the sensorimotor cortex than stronger but implausible stimulations; (iii) frontal activities under plausible scenarios negatively correlated with plausibility violation costs in the sensorimotor cortex. These results potentially indicate frontal regulation of sensory processing and extend previous evidence of contextual modulation to the tactile sense.
How the Online Learning Assistant Program Supported Course Instructor Wellbeing during a Transition to Remote Teaching
Authors: Drewery David , Potwarka Melissa , Potwarka Luke 
Published: December 2022

Abstract
When the COVID-19 pandemic emerged, many leisure studies course instructors were asked to transition from in-person to remote teaching. Such a transition affected course instructors’ wellbeing and, in turn, students’ learning experiences in negative ways. At the same time, many talented work-integrated learning students were without work because of challenges faced by organizations that would typically host students. In response to this situation, the University of Waterloo created the Online Learning Assistant (OLA) Program. The programme hired, trained and mobilized over 300 co-operative education students in support of course instructors’ remote teaching. This case describes the positive impact of the OLA Program on one leisure studies course instructor’s wellbeing during a transition to remote teaching. In partnership with the OLA, the instructor created a supportive remote-learning environment for students that resulted in a remote-teaching award. The case offers an example of an innovative work-integrated learning programme that supported teaching and learning in leisure-related education.

Information
© CAB International 2022
Alpha-Gal Syndrome in the Infectious Diseases Clinic: A Series of 5 Cases in Central North Carolina
Authors: Boyce Ross M , Schulz Abigail , Mansour Odai , Giandomenico Dana , Farel Claire E , Commins Scott P 
Published: December 2022

Abstract

Background
Alpha-gal syndrome (AGS) is a recently described allergy to galactose-α-1,3-galactose, an oligosaccharide present in mammalian meat. AGS can present with angioedema, urticaria, and anaphylaxis arising 3–6 hours after ingestion, although symptoms such as gastrointestinal distress, fatigue, and arthralgias are also reported. Because AGS appears to be associated with tick bites, patients may present to infectious diseases (ID) clinics for evaluation.

Methods
We documented a series of 5 patients referred to the University of North Carolina ID Clinic between 2020 and 2022 for various tick-borne infections that were found to have symptoms and laboratory testing consistent with AGS. Patients were subsequently referred to the Allergy and Immunology Clinic.

Results
Patients were referred to the ID Clinic for persistent symptoms following positive tick-borne disease testing or presumed tick-borne infection. All patients had an elevated alpha-gal immunoglobulin E and clinical presentation consistent with AGS. Common symptoms included episodic gastrointestinal distress (eg, cramping, nausea, diarrhea), fatigue, arthralgias, and subjective cognitive impairment, but a notable absence of severe anaphylaxis. Four patients were seen by at least 1 nonallergy specialist prior to referral to ID. Patients reported substantial improvement in their symptoms following dietary restriction.

Conclusions
ID physicians should be aware of AGS as a cause of persistent, nonspecific symptoms following a tick exposure or tick-borne illness. Further research is needed to determine the prevalence of alpha-gal sensitization and AGS following tick-borne bites.
Modulation of sensorimotor oscillation by sensory gating in the frontal cortex
Authors: Fujiwara Yosuke , Takahashi Osamu , Ushiba Junichi 
Published: December 2022

Objectives
To reveal that nonprimary motor-related areas located in the upper stream of the sensorimotor area are associated with self-regulated local electroencephalogram changes in the sensorimotor area during motor tasks.

Methods
Among healthy participants, we measured the gating of somatosensory-evoked potentials (SEPs) in nonprimary motor-related areas and the sensorimotor area, and event-related desynchronisation, which reflects the excitability changes of the neurons localised in the sensorimotor area during motor execution and imagery.

Results
We confirmed significant correlations between beta-band event-related desynchronisation and the somatosensory-evoked potential gating of frontal N30 during motor imagery and execution (motor imagery: r = 0.723; P < 0.05; motor execution: r = 0.873; P < 0.05), and nonsignificant correlations between beta-band event-related desynchronisation and the somatosensory-evoked potential gating of N20 (motor imagery: r = 0.079; P > 0.05; motor execution: r = 0.449; P > 0.05).

Conclusions
The N30 gating of SEPs, with which the beta-band event-related desynchronisation was associated, implies that they modulate sensory input to the supplementary motor area/premotor cortex during motor tasks, the beta-band self-regulated local electroencephalogram changes in the sensorimotor area related sensory input to the supplementary motor area/premotor cortex, and not to primary sensory area derived from N20 gating. This study suggests that some motor commands are derived from sensory gating in the supplementary motor area/premotor cortex.
Simulated climate change causes asymmetric responses in insect life history timing potentially disrupting a classic ecological speciation system
Authors: Lackey Alycia C. R. , Deneen Pheobe M. , Ragland Gregory J. , Feder Jeffrey L. , Hahn Daniel A. , Powell Thomas H. Q. 
Published: December 2022

ABSTRACTClimate change may alter phenology within populations with cascading consequences for community interactions and on-going evolutionary processes. Here, we measured the response to climate change in two sympatric, recently diverged (~170 years) populations ofRhagoletis pomonellaflies specialized on different host fruits (hawthorn and apple) and their parasitoid wasp communities. We tested whether warmer temperatures affect dormancy regulation and its consequences for synchrony across trophic levels and temporal isolation between divergent populations. Under warmer temperatures, both fly populations developed earlier. However, warming significantly increased the proportion of maladaptive pre-winter development in apple, but not hawthorn, flies. Parasitoid phenology was less affected, potentially generating ecological asynchrony. Observed shifts in fly phenology under warming may decrease temporal isolation, potentially limiting on-going divergence. Our findings of complex sensitivity of life-history timing to changing temperatures predict that coming decades may see multifaceted ecological and evolutionary changes in temporal specialist communities.
The Holdup Multiplex, an assay for high-throughput measurement of protein-ligand affinity constants using a mass-spectrometry readout
Authors: Delalande François , Gogl Gergo , Rohrbacher Aurélien , Kostmann Camille , Eberling Pascal , Carapito Christine , Travé Gilles , Monsellier Elodie 
Published: December 2022

AbstractThe accurate description and subsequent modeling of protein interactomes requires quantification of their affinities at proteome-wide scale. Here we develop and validate the Holdup Multiplex, a versatile assay for high-throughput measurement of protein-ligand affinity constants that uses mass-spectrometry as readout. The method can quantify thousands of affinities in one single run, with high precision and over several orders of magnitude. We applied this strategy to the seven human 14-3-3 isoforms, quantifying in a few sample-runs their interaction with 1,000 different phosphopeptides. We were able to identify hundreds of new 14-3-3 binding sites. We showed that the seven human 14-3-3 display similar specificities but staggered affinities, 14-3-3g being always the best binder and 14-3-3ε and σ, the weakest. Finally, we identified dozens of 14-3-3 bindings sites, some intervening in key signaling pathways, that were either stabilized or destabilized by the phytotoxin Fusicoccin-A. Our approach, which throughput can be pushed up to the sensitivity limit of the mass-spectrometry setup, is applicable to any category of protein-ligand interactions and thus bears a wide potential both for high-throughput interactomics and chemoproteomics.
Synthesis and structural optimization of 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors
Authors: Tomanová Monika , Kozlanská Karolína , Jorda Radek , Jedinák Lukáš , Havlíková Tereza , Řezníčková Eva , Peřina Miroslav , Klener Pavel , Dolníková Alexandra , Cankař Petr , Kryštof Vladimír 
Published: December 2022

AbstractTherapy of FLT3-positive acute myeloid leukemia still remains complicated, despite the availability of newly approved kinase inhibitors. Various strategies to avoid reduced efficacy of therapy are explored including the development of dual targeting compounds, which inhibit FLT3 and another kinase necessary for survival and proliferation of AML cells. We have designed new 2,7,9-trisubstituted 8-oxopurines as FLT3 inhibitors and report here structure-activity relationship studies. We demonstrated that substituents at positions 7 and 9 modulate activity between CDK4 and FLT3 kinase and the isopropyl group at position 7 increased substantially the selectivity toward FLT3 kinase, which led to the discovery of compound15a(9-cyclopentyl-7-isopropyl-2-((4-(piper-azin-1-yl)phenyl)amino)-7,9-dihydro-8H-purin-8-one). Cellular analyses in MV4-11 cells revealed inhibition of autophosphorylation of FLT3 kinase in nanomolar doses including suppression of downstream STAT5 and ERK1/2 phosphorylation. We also describe mechanistic studies in cell lines and activity in a mouse xenograft model in vivo.
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
Authors: Lopez-Erauskin Jone , Bravo-Hernandez Mariana , Presa Maximiliano , Baughn Michael W. , Melamed Ze’ev , Beccari Melinda S. , Agra de Almeida Quadros Ana Rita , Zuberi Aamir , Ling Karen , Platoshyn Oleksandr , Niño-Jara Elkin , Ndayambaje I. Sandra , Arnold-Garcia Olatz , McAlonis-Downes Melissa , Cabrera Larissa , Artates Jonathan W. , Ryan Jennifer , Bennett Frank , Jafar-nejad Paymaan , Rigo Frank , Marsala Martin , Lutz Cathleen M. , Cleveland Don W. , Lagier-Tourenne Clotilde 
Published: December 2022

AbstractThe human mRNA most affected by TDP-43 loss-of-function is transcribed from theSTMN2gene and encodes stathmin-2 (also known as SCG10), whose loss is a neurodegenerative disease hallmark. Here using multiplein vivoapproaches, including transient antisense oligonucleotide (ASO)-mediated suppression, chronic shRNA-mediated depletion in aging mice, and germline deletion, we establish stathmin-2 to be essential for acquisition and maintenance of neurofilament-dependent structuring of axoplasm critical for maintaining diameter and conduction velocity of large-myelinated axons. Sustained stathmin-2 loss from an otherwise mature adult nervous system is demonstrated over a time course of eight months to initiate and drive motor neuron disease that includes 1) shrinkage in inter-neurofilament spacing that is required to produce a three-dimensional space filling array that defines axonal caliber, 2) collapse of mature axonal caliber with tearing of outer myelin layers, 3) reduced conduction velocity, 4) progressive motor and sensory deficits (including reduction of the pain transducing neuropeptide CGRP), and 5) muscle denervation. Demonstration that chronic stathmin-2 reduction is itself sufficient to trigger motor neuron disease reinforces restoration of stathmin-2 as an attractive therapeutic approach for TDP-43-dependent neurodegeneration, including the fatal adult motor neuron disease ALS.
Safeguarding eucalypt diversity through conservation‐focused tree planting
Authors: St‐Laurent Olivia , Mokany Karel , Pollock Laura J. 
Published: December 2022

Abstract

The UN decade on ecosystem restoration calls for the preservation of global biodiversity. Safeguarding biological diversity is crucial for the well‐being of people and the persistence of nature. Tree planting offers a nature‐based solution to carbon abatement with significant potential to benefit biodiversity, but how well different aspects of biodiversity are captured in plantings is not well known.

We assemble a database of 218 species and >80,000 observations from environmental tree plantings in Australia, and investigate how well they capture eucalypt diversity, including possible climate change effects. We compare this to hypothetical planting scenarios that maximize biodiversity benefits for species of conservation interest. Eucalypt species that are rare, endemic, evolutionarily distinct or listed in the Environment Protection and Biodiversity Act (EPBC) are prioritized.

We find that environmental tree plantings are dominated by very common species likely to benefit from climate change, with less than 1% of rare or evolutionarily distinct species represented. All conservation scenarios outperform business‐as‐usual. The scenario prioritizing endemic species while considering climate change more than doubles the average extent of occurrence for species of conservation interest. It allocates four times more planting area to species of conservation interest compared to a business‐as‐usual approach and decreases weighted endemism (a favourable outcome here) by 38% on average, demonstrating the positive impact of conservation‐focused tree planting on biodiversity.

Synthesis and applications. Everywhere, governments are making commitments to halt biodiversity loss. Conservation‐focused tree planting can advance our goal of safeguarding biodiversity while still contributing to carbon capture. We show that eucalypt species of conservation interest can benefit substantially from tree planting where the primary goal is biodiversity conservation, compared to the current approach to planting, which we have found largely benefits commonly occuring species. We measure potential distribution gains for eucalypt species that are rare, endemic, evolutionarily distinct and at risk of extinction (listed), and identify the most important eucalypt species to plant across Australia, taking the effects of climate change into account. Our framework for selecting species to plant based on a range of conservation goals can serve as a guide for future environmental tree planting initiatives.
Folded: A toolkit to describe mammalian herbivore dentition from 2D images
Authors: Sanisidro Oscar , Arganda‐Carreras Ignacio , Cantalapiedra Juan L. 
Published: December 2022

Abstract

Dental morphology is a major aspect of ecological and evolutionary studies of both extant and fossil mammalian species. Mammalian dentitions are diverse feeding systems that can be defined through continuous numerical descriptors of the enamel pattern.

We developed a comprehensive toolkit to quantify complex occlusal enamel patterns from two‐dimensional images of herbivore mammals, widespread in the scientific literature, in form of three novel enamel complexity descriptors: two‐dimensional orientation patch count (2D OPC), enamel folding (EF), and enamel thickness (ET). Previously proposed parameters such as occlusal enamel index or indentation index are implemented as well.

The current method is devised for extracting continuous variables of enamel complexity from macro and microherbivore mammalian species with conspicuous wear facets. A general case study is proposed using two clades within the Family Rhinocerotidae containing species regarded as hypsodonts. The results show that antagonist dental adaptations were achieved through disparate evolutionary strategies in both groups. To test the robustness of this tool under different practical scenarios, other mammalian groups have been evaluated as well. Additional sensitivity analyses include the impact of image size, rotation, or differences in dental wear.

Our approach differs from previous 2D techniques in its affordability, versatility, and control over individual regions within each tooth while delivering continuous numerical data. Additionally, the 2D reference images required as input are widespread in the literature and easier to process in comparison to 3D data alternatives.
Anti‐Müllerian hormone stimulates expression of the collagen‐specific chaperone 47‐kDa heat shock protein in bovine uterine epithelial cells
Authors: Ferdousy Raihana Nasrin , Kadokawa Hiroya 
Published: December 2022

AbstractUterine collagen is the most abundant component of the uterine extracellular matrix and plays a critical role in pregnancy. The 47‐kDa heat shock protein (HSP47) is the sole collagen‐specific molecular chaperone. We investigated the mechanisms regulating the expression of HSP47 in the uterus by assessing the effect of anti‐Müllerian hormone (AMH) stimulation on HSP47 expression in cultured bovine uterine epithelial cells. AMH receptor type 2 (AMHR2), AMH, and HSP47 expression was assessed by fluorescence immunocytochemistry in uterine epithelial layers of the uteri of Japanese Black cows. The effect of AMH on HSP47 expression was assessed in cultured epithelial cells. The effect of MEK/ERK inhibitor on AMH‐induced HSP47 expression was also assessed. We confirmed the expression of AMHR2, AMH, and HSP47 in the uterine epithelial layers. We confirmed the expression of AMHR2, AMH, HSP47, and type IV collagen in cultured uterine epithelial cells. AMH treatment at 10 or 100 ng/ml promoted significant HSP47 expression (p < 0.05). MEK/ERK inhibitor U0126 pretreatment suppressed such AMH stimulation on HSP47. These findings indicate that AMH induced HSP47 protein expression through the ERK pathway in bovine uterine epithelial cells.
No borders on a fragile planet: Introducing four lay models of social psychological precarity to support global human identification and citizenship
Authors: Mahendran Kesi , Nieland Sue , English Anthony , Goodman Simon 
Published: December 2022

AbstractMeasures such as Identification with all humanity (IWAH) and global identification and citizenship (GHIC) are positivity correlated with measures of humanitarianism, cosmopolitanism and environmental concern. Research using these measures suggests that most citizens have low‐global identification scores. This article sheds light on this finding by investigating how global identification relates to precarity and migration (neither of which are measured in the IWAH/GHIC). The study conducted in England, Scotland and Sweden introduces a qualitative dialogical approach to GHIC. This involves measuring migration‐mobility in dialogical interviews and controlling and removing borders on world maps—using an interactive world mapping task (N = 23). Participants articulate four social representations relating to a fragile earth, enduring colonial settler/native conflict, ingroup/outgroup conflict or, in contrast, a cooperative plentiful planet where borders are unnecessary. Such social representations demonstrate the importance of planetary consciousness and relate to four lay models of social psychological precarity related to intergroup competition, global conflict, economic rationality and human‐made borders. In conclusion, all participants employ lay models of social psychological precarity when discussing sovereignty, migration and belonging. We recommend psychologists investigating GHIC include measures of social psychological precarity and migration‐mobility.