bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does anthropization affect physiology, behaviour and life‐history traits of Montagu's harrier chicks?
Authors: Rabdeau J. , Desbonnes M. , Bretagnolle V. , Moreau J. , Monceau K. 
Published: July 2022

AbstractThe last century has seen a steep decline in biodiversity, and anthropization is considered one of the major drivers of this decline. Anthropogenic disturbances, due to human presence and/or activities, may be perceived as chronic stressors by wildlife and potentially lead to deleterious effects on traits related to fitness. The main objective of the present study was to highlight the effects of these anthropogenic elements on wild birds on sparsely urbanized farmland, far less studied than in urbanized areas. We investigated during four successive breeding seasons whether the anthropization level, assessed by infrastructure density around nests, and the harvesting conditions around nests may impact physiological, behavioural and life‐history traits of Montagu's harrierCircus pygarguschicks. Higher anthropization levels were associated with higher basal corticosterone levels in nestlings during only one breeding season and a lower body condition at fledging for females, probably because they suffered from higher starvation than males. Nestlings reared in more anthropized areas or in harvested crops before their fledging harboured more fault bars on rectrices than those reared in less anthropized areas or in unharvested crops regardless of year and sex, which is suggestive of higher stress during development. Nestling behaviours were also impacted by anthropization level and harvesting conditions: chicks in harvested crops were more aggressive and in areas with higher anthropization levels more prone to escape than others. Because Montagu's harrier is a protected species, the impacts highlighted in the present study are a matter of concern, especially regarding farmland landscape modifications, and we advise limiting perturbations in areas where Montagu's harriers usually nest.
The effect of overlapping surgical scheduling on operating theatre productivity: a narrative review
Authors: Pandit J. J. , Ramachandran S. K. , Pandit M. 
Published: July 2022

SummaryThis article reviews the background to overlapping surgery, in which a single senior surgeon operates across two parallel operating theatres; anaesthesia is induced and surgery commenced by junior surgeons in the second operating theatre while the lead surgeon completes the operation in the first. We assess whether there is any theoretical basis to expect increased productivity in terms of number of operations completed. A review of observational studies found that while there is a perception of increased surgical output for one surgeon, there is no evidence of increased productivity compared with two surgeons working in parallel. There is potential for overlapping surgery to have some positive impact in situations where turnover times between cases are long, operations are short (<2 h) and where ‘critical portions’ of surgery constitute about half of the total operation time. However, any advantages must be balanced against safety, ethical and training concerns.
A phase 2, multicentre, open‐label trial (ACE‐LY‐003) of acalabrutinib in patients with relapsed or refractory marginal zone lymphoma
Authors: Strati Paolo , Coleman Morton , Champion Rebecca , Ma Shuo , Patti Caterina , Levy Moshe Y. , Lossos Izidore S. , Geethakumari Praveen Ramakrishnan , Lam Selay , Calvo Roser , Higgins Kara , Budde Lihua E. 
Published: July 2022

SummaryAcalabrutinib, a Bruton tyrosine kinase inhibitor, demonstrated greater selectivity and improved safety versus ibrutinib in a head‐to‐head trial in relapsed/refractory (R/R) chronic lymphocytic leukaemia. In the R/R marginal zone lymphoma (MZL) cohort (phase 2) of a phase 1b/2 trial (NCT02180711), 43 patients with MZL and at least one prior therapy received acalabrutinib 100 mg twice daily until disease progression or unacceptable toxicity [median age 69 years (range 42–84); median one (1–4) prior systemic regimens]. Median follow‐up was 13.3 months (range 0.5–45.5). Among 40 patients evaluable for response, investigator‐assessed overall response rate was 53% [95% confidence interval (CI) 36%–69%] with five (13%) complete responses. Tumour reduction occurred in 40 (93%) of the treated patients. Median time to response was 2.9 months (median duration of response not estimable). Estimated median progression‐free survival (PFS) was 27.4 months (12‐month PFS rate, 67%). Five patients died (disease progression, n = 4; septic shock, n = 1). Seventeen patients (40%) had grade 3 or higher adverse events (AEs), most commonly neutropenia (14%), anaemia, dyspnoea (7% each), fatigue and thrombocytopenia (5% each). Hypertension occurred in 5%; atrial fibrillation/flutter and major haemorrhage were not reported. AEs led to treatment discontinuation in three (7%) patients. Acalabrutinib was active and well tolerated in patients with R/R MZL.
Ultrasonography can be used to predict the location of manica flexoria tears in horses
Authors: Hibner‐Szaltys Maria , Cavallier Francesca , Cantatore Federica , Withers Jonathan M. , Marcatili Marco 
Published: July 2022

SummaryBackgroundManica flexoria (MF) tears are a well‐recognised cause of lameness in horses presenting with effusion of the digital flexor tendon sheath (DFTS). Ultrasonography (US) is a commonly used first line imaging modality during examination of horses presented with DFTS effusion. However, its reported sensitivity for detection of MF tears is low.ObjectivesTo describe a novel US technique to predict the location of the MF tear.Study designProspective descriptive observational study.MethodsTwenty‐two horses (23 limbs) diagnosed with MF tears were included in the study. A standardised US protocol including examination with the limb weight bearing and non‐weight bearing was used. Furthermore, with the limb held in flexed position digital pressure was simultaneously applied to the medial and lateral proximal DFTS outpouchings in axial direction. The aim was to create turbulence of the synovial fluid within the DFTS and improve visualisation of the torn MF. The US examination was performed by one experienced operator and one junior clinician. All horses underwent tenoscopic examination.ResultsIn all cases MF tear was diagnosed during tenoscopic examination of the DFTS. The location of the MF tear was correctly predicted in 91.3% (21/23) of the limbs. The main features used to predict location of the MF tear included floatation of the torn fibres of the MF within the synovial fluid, increased distance between DDFT and SDFT on the side at which the MF was torn and recoiling of the MF on the side contralateral to the tear.Main limitationsRelatively small number of cases included.ConclusionsThe novel US technique was useful to identify the location of MF tear and facilitate identification of the previously described ultrasonographic features consistent with tears of the MF. The agreement between operators was perfect as from the data analysis.
Sixth Åland Island Conference on von Willebrand disease
Authors: Berntorp Erik , Trakymienė Sonata S. , Federici Augusto B. , Holstein Katharina , Corrales‐Medina Fernando F. , Pierce Glenn F. , Srivastava Alok , Prondzinski Mario von Depka , Johnsen Jill M. , Zupan Irena P. , Halimeh Susan , Nummi Vuokko , Roberts Jonathan C. 
Published: July 2022

AbstractIntroductionThe sixth Åland Islands Conference on von Willebrand disease (VWD) on the Åland Islands, Finland, was held from 20 to 22 September 2018.AimThe meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.Results and discussionThe topics covered both clinical aspects of disease management, and biochemical and laboratory insights into the disease. The clinical topics discussed included epidemiology, diagnosis and treatment of VWD in different countries, management of children with VWD, bleeding control during surgery, specific considerations for the management of type 3 VWD and bleeding control in women with VWD. Current approaches to the management of acquired von Willebrand syndrome were also discussed. Despite significant advances in the understanding and therapeutic options for VWD, there remain many challenges to be overcome in order to optimise patient care. In comparison with haemophilia A, there are very few registries of VWD patients, which would be a valuable source of data on the condition and its management. VWD is still underdiagnosed, and many patients suffer recurrent or severe bleeding that could be prevented. Awareness of VWD among healthcare practitioners, including non‐haematologists, should be improved to allow timely diagnosis and intervention. Diagnosis remains challenging, and the development of fast, simple assays may help to facilitate accurate and rapid diagnosis of VWD.
Alterations in the structure and function of the brain in adolescents with new daily persistent headache: A pilot MRI study
Authors: Szabo Edina , Chang Yu‐Hsing Cindy , Shulman Julie , Sieberg Christine B. , Sethna Navil F. , Borsook David , Holmes Scott A. , Lebel Alyssa A. 
Published: July 2022

AbstractObjectiveThe purpose of this study was to explore brain morphological and functional connectivity alterations in adolescents with new daily persistent headache (NDPH) compared to pain‐free, healthy controls.BackgroundNDPH is one of the most disabling and least understood primary headache conditions. To date, no studies have considered the role of brain function and structure in pediatric patients with NDPH.MethodsIn this cross‐sectional study, resting‐state functional and structural images were acquired for 13 patients with NDPH (M age = 15.9, standard deviation [SD] ± 1.4) and 13 age‐ and sex‐matched controls (M age = 16.2, SD ± 1.8) using magnetic resonance imaging. Participants were recruited from the Pediatric Headache Program at Boston Children's Hospital and from the Greater Boston area. In patients, clinical features of NDPH, including disease duration, pain intensity ratings, pain sensitivity, and functional disability were also assessed, and their associations with functional and structural brain alterations were explored.ResultsCompared to controls, patients with NDPH demonstrated reduced cortical thickness in the bilateral superior temporal gyrus, left superior, and middle frontal gyrus areas (p < 0.05, Monte Carlo corrected for multiple comparisons). Furthermore, reduced cortical thickness of the left superior frontal gyrus was related to elevated pain sensitivity in NDPH (r = −0.79, p = 0.006). Patients showed altered functional connectivity between regions involved in emotional and cognitive networks of pain, including the amygdala, insula, frontal regions, and cerebellar subregions.ConclusionThe present study provides the first preliminary evidence of functional and structural brain differences in pediatric patients with NDPH compared to controls. Identifying alterations in cortical thickness and resting‐state connectivity between specific brain regions could provide characteristics of NDPH and probable mechanisms that may guide personalized therapeutic interventions.
Progression from early to advanced stage of immune‐related cholangitis
Authors: Hagiwara Satoru , Yoshida Takeshi , Nishida Naoshi , Ida Hiroshi , Ueshima Kazuomi , Minami Yasunori , Takita Masahiro , Aoki Tomoko , Morita Masahiro , Cishina Hirokazu , Komeda Yoriaki , Yoshida Akihiro , Hayashi Hidetoshi , Nakagawa Kazuhiko , Kudo Masatoshi 
Published: July 2022

AbstractAimWe report a rare case of immune‐related cholangitis in which the natural course could be demonstrated.Case PresentationEight courses of pembrolizumab maintenance therapy were given as first‐line treatment for squamous cell lung cancer; however, the patient was subsequently hospitalized due to a rapid increase in hepatobiliary enzymes. On endoscopic ultrasound, the common bile duct was dilated to 11 mm, and the wall, throughout its length from the papilla, was thickened. Endoscopic retrograde cholangiopancreatography showed no obvious stenosis in the lower bile duct; however, a parapapillary diverticulum was found, and papillary incision and bile duct plastic stent insertion were carried out. However, the liver disorder did not improve and overt jaundice appeared subsequently; therefore, an immune‐related cholangitis was suspected, and prednisolone (PSL) 35 mg/day was introduced from day 59 of admission. Following PSL initiation, a decrease in serum bilirubin level was observed; however, significant decrease was not observed in alkaline phosphatase. Given the history of recurrent infectious cholangitis, magnetic resonance cholangiopancreatography was carried out on day 70 of admission. The intrahepatic bile duct showed stenosis and dilated findings, which was considered to be a factor for repeated infectious cholangitis.ConclusionNo previous case reports have described the changes and progression in bile duct images in immune‐related adverse events. Therefore, this case is noteworthy for considering the progression of immune‐related cholangitis.
Integrating 16S RRNA gene sequencing and metabolomics to evaluate the association between gut microbiota and serum metabolites in patients with myositis
Authors: Luo Yue-Bei , Liu Yangtengyu , Li Qiuxiang , Duan Huiqian , Luo Zhaohui , Yang Huan , Xu Liqun 
Published: July 2022

Abstract

Aims
Gut microbiota and metabolites have a profound impact on the maintenance of body health. In this study, we assessed the association between gut microbiota and serum metabolite changes in myositis using 16S rRNA gene sequencing and metabolomics to provide new ideas for screening and treating myositis.

Methods and results
Blood and faecal samples were collected from 20 myositis patients and 20 healthy control subjects. Then, 16S rRNA gene sequencing, enzyme-linked immunosorbent assays and untargeted metabolomics study were performed to evaluate the relationship between gut microbiota and serum metabolites in patients with myositis. Compared to healthy control subjects, the blood samples from the patients with myositis had elevated levels of interleukin-4 (IL-4), tumour necrosis factor-α (TNF-α), and malondialdehyde (MDA) and decreased superoxide dismutase (SOD) levels. The increase in Bacteroidota (including Bacteroides and Parabacteroides, but not Prevotella) and the decrease in Firmicutes in the patients were accompanied by functional changes in amino acid and lipid metabolism. The gut microbiota (Bacteroides and Parabacteroides) were negatively correlated with the differential serum metabolites (glutamate and taurine). The differential serum metabolites (glutamate, pyrrolidonecarboxylic acid, and taurine) were also correlated with inflammatory factors (IL-4 and TNF-α) and oxidative stress indexes (MDA and SOD).

Conclusion
Dysbiosis of gut microbiota in patients with myositis was accompanied by changes in inflammatory factors, oxidative stress indexes, and small molecule metabolites in serum.

Significance and impact of study
Blood and faecal biomarkers could be used for screening myositis.
Learning analytics support to teachers' design and orchestrating tasks
Authors: Amarasinghe Ishari , Michos Konstantinos , Crespi Francisco , Hernández‐Leo Davinia 
Published: July 2022

AbstractBackgroundData‐driven educational technology solutions have the potential to support teachers in different tasks, such as the designing and orchestration of collaborative learning activities. When designing, such solutions can improve teacher understanding of how learning designs impact student learning and behaviour; and guide them to refine and redesign future learning designs. When orchestrating educational scenarios, data‐driven solutions can support teacher awareness of learner participation and progress and enhance real time classroom management.ObjectivesThe use of learning analytics (LA) can be considered a suitable approach to tackle both problems. However, it is unclear if the same LA indicators are able to satisfactorily support both the designing and orchestration of activities. This study aims to investigate the use of the same LA indicators for supporting multiple teacher tasks, that is, design, redesign and orchestration, as a gap in the existing literature that requires further exploration.MethodsIn this study, first we refer to the previous work to study the use of different LA to support both tasks. Then we analyse the nature of the two tasks focusing on a case study that uses the same collaborative learning tool with LA to support both tasks.ImplicationsThe study findings led to derive design considerations on LA support for teachers’ design and orchestrating tasks.
The record and threats of the invasion of palometa Serrasalmus maculatus (Characiformes: Serrasalmidae) in the Patos lagoon drainage, southern Brazil
Authors: Bertaco Vinicius Araújo , Becker Fernando G. , Azevedo Marco A. , Ferrer Juliano , Behr Everton R. , de Moraes Tiago R. , Fagundes Nelson J. R. , Malabarba Luiz R. 
Published: July 2022

AbstractWe report the occurrence of an invasive alien species, palometa Serrasalmus maculatus, in the Patos Lagoon drainage. Primary occurrence data were based on three specimens captured and preserved as vouchers in scientific collections. Additionally, we searched for secondary records from unpublished scientific sources, public agencies reports and media news to find additional reports. We discussed the possible pathways of invasion, suggesting as the vector of introduction transpositions from the Uruguay River basin. Ecological implications for ichthyofauna, environmental impacts and risk of other events of invasion in the adjoining basins are discussed.
Influence of frequency on ultrasound‐assisted extraction of betalains from Stenocereus queretaroensis peel
Authors: Soto‐Castro Delia , Castellanos Francisco 
Published: July 2022

AbstractOptimization of green extraction to obtain natural colorants is relevant as the stability of colors can be influenced by the energy and temperature of the extraction process. The influence of frequency on ultrasound‐assisted extraction of betalains from Stenocereus queretaroensis peel in Opuntia ficus indica mucilage at room temperature is analyzed. Frequencies of 0.04, 2.25, 7.5, and 15 MHz, higher than those commonly used (0.02–0.5 MHz), were employed in this work. A dependence of extraction efficiency on frequency applied was found, being 2.25 MHz the optimal frequency with the highest extraction yields and with an 8°C increase in the temperature of the system, without requiring cooling systems, favored by the extraction sequence of nine ultrasonic pulses of 10 min, each pulse separated by a pause of 5 min.Practical ApplicationsBetalains (BTs) are a source of red to yellow natural colorants, as an alternative to synthetic ones. Because of their nature, BTs could be lost during the extraction process, requiring for research of optimal extraction methods. The green methodology herein proposed, using mucilage as extracting medium and applying a sequence of nine pulses of 10 min, each pulse separated by a pause of 5 min, allows for a faster extraction of bioactive compounds, without significantly increasing the system temperature, therefore avoiding the use of cooling systems, minimizing costs, without degrading the bioactive compounds, providing an alternative for utilization of waste materials, increasing profits and diminishing waste. The use of an optimal frequency for ultrasound‐assisted extraction of bioactive compounds could be easily implemented for industrial or for communal purposes due to the feasibility of customizing ultrasonic transducers.
Dissemination of a long‐term care planning tool, PlanYourLifespan.org, through community‐based stakeholder leaders
Authors: Lindquist Lee A. , Wong Norine , Forcucci Chris , Rogers Beverly , Ramirez Ana , Ramirez‐Zohfeld Vanessa 
Published: July 2022

AbstractBackgroundGeriatrics research generally cumulates in academic journal publications, with variable diffusion to patients and communities. PlanYourLifespan.org is a free, evidence‐based tool that assists older adults, and their loved ones, to better understand and plan for their long‐term support needs. There is a need to effectively disseminate geriatrics research, such as PlanYourLifespan.org, to communities that may directly benefit from this research.ObjectiveTo leverage community‐based stakeholder leaders, utilizing a train‐the‐trainer program, to disseminate PlanYourLifespan.org and evaluate the extent of the dissemination.MethodsUsing a train‐the‐trainer strategy, community stakeholder leaders from the original study paired up with newly recruited community stakeholder leaders. New community stakeholder leaders were trained on dissemination, using a “how‐to‐disseminate” web‐based toolkit—developed as part of this project. Newly trained community stakeholder leaders subsequently trained additional community stakeholder leaders who conducted and tracked dissemination activities in their communities. Google Analytics tracked newly created PlanYourLifespan.org accounts, login sessions, and daily website visitors.ResultsFive newly trained community stakeholder leaders disseminated PlanYourLifespan.org over a three‐month period. Cumulatively, on the day of the dissemination activity, there were 11,361 PlanYourLifespan.org log‐ins (average: 378.7 log‐ins/activity day), 89,068 log‐ins (average: 2969 log‐ins/activity week) one‐week after the activity, and 319,154 log‐ins (average: 10,638 log‐ins/activity month) one month after the dissemination activity. Approximately 9.4 new PlanYourLifespan.org accounts were created one‐week post dissemination activity and over 1100 new accounts in the one‐month period thereafter.ConclusionsWide dissemination of PlanYourLifespan.org occurred by leveraging a train‐the‐trainer approach with community stakeholder leaders. Researchers should consider collaborating early on with community stakeholders to meaningfully disseminate results.
Quantification and comparison of teleost scleral cartilage development and growth
Authors: Zinck Nicholas W. , Franz‐Odendaal Tamara A. 
Published: July 2022

AbstractThe ocular skeleton is composed of the scleral cartilage and the scleral ossicles. Teleost scleral cartilage is composed of a single layer of chondrocytes embedded in the sclera of the eye. The teleost scleral cartilage ring can vary in depth across teleost families and species, from a narrow ring a few cells wide to a deeper ring that resembles a cup and surrounds the entire sclera. However, very little research has been conducted on the development and morphology of teleost scleral cartilage. Thus, this study aims to characterize the development of the scleral cartilage in the zebrafish and Mexican tetra, with respect to the timing of emergence, depth throughout development, and positioning within the eye. We hypothesized that the scleral cartilage would first emerge in the scleral tissue closely abutting the ora serrata, and that growth would proceed in an anterior‐to‐posterior direction, resulting in differences in scleral cartilage depth between different fish species. We found that the scleral cartilage ring does not develop uniformly along its circumference, and that its relationship to the ora serrata varies between the rostral and caudal regions. Furthermore, distinct differences in the growth trajectory of the scleral cartilage indicate that the deep scleral cartilage of the Pachón cavefish is the result of both decreased eye size and prolonged cartilage growth. A significant difference in the size of the scleral chondrocytes was also noted. Overall, this study provides the first characterization of early scleral cartilage development in teleost fish and indicates that some aspects of scleral cartilage development and morphology are highly conserved while others are not.