bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing and utilizing a tool for assessing the status of evidence-informed health policy-making in Iran (SASHA study)
Authors: Yazdizadeh Bahareh , Sajadi Haniye Sadat , Mohtasham Farideh , Mohseni Mahsa , Majdzadeh Reza 
Published: August 2022

Abstract
IntroductionIn order to promote evidence-informed health policy-making (EIHP) and address its challenges, it is necessary to measure it more objectively. In this study, as part of a bigger study entitled “A roadmap for strengthening evidence-informed health policy-making in Iran”, we tried to develop a tool to measure the instrumental use of evidence in health policy-making and to utilize it. MethodsWe performed literature review and in-depth interviews to develop and standardize the SASHA tool. The SASHA tool was developed based on the policy-making cycle and the evidence required for each cycle in five sections, clarifying the problem, identifying and selecting appropriate solutions, contextualizing, implementing, and monitoring & evaluation of the selected solutions. After standardizing the tool, we assessed 14 policies/programs using document review and semi-structured interviews with key persons related to each policy. Results Based on our results, the SASHA tool is an appropriate tool for guiding and measuring evidence-informed policy-making. SASHA has been successful in certain aspects and unsuccessful in others in objectively measuring the EIHP status. The most important limitation in this regard was the lack of policy-making documentation that makes policy-makers the only sources of data, which not only imposes information bias but also reduces the possibility of data triangulation. The role of evidence derived from systematic reviews and secondary data analysis was very poor.ConclusionThis study has shown that the feasibility of the SASHA tool in objectively measuring EIHP depends on the availability of data on decision-making processes throughout policy-making cycles. The policymaker’s experience is dominant in problem identification and agenda-setting and the roles of systematic reviews and secondary data analysis are weak in all policy cycle stages.
Sensitivity-Guided Iterative Parameter Identification and Data Generation with BayesFlow and PELS-VAE for Model Calibration
Authors: Zhang Yi , Mikelsons Lars 
Published: August 2022

Abstract
Calibration of complex system models with a large number of parameters using standard optimization methods is often extremely time-consuming and not fully automated due to the reliance on all-inclusive expert knowledge. We propose a sensitivity-guided iterative parameter identification and data generation algorithm. The sensitivity analysis replaces manual intervention, the parameter identification is realized by BayesFlow allowing for uncertainty quantification, and the data generation with the Physics-Enhanced Latent Space Variational Autoencoder (PELS-VAE) between two iteration steps enables inference of weakly identifiable parameters. A complete calibration experiment was conducted on a thermal model of an automotive cabin. The average relative error rate over all parameter estimations of 1.62% and the mean absolute error of calibrated model outputs of 0.108 ◦C validate the feasibility and effectiveness of the method. Moreover, the entire procedure accelerates up to one day, whereas the classical calibration method takes more than one week.
Magnetic Properties of La0.81Sr0.19Mn0.9Fe0.1−𝑥Zn𝑥O3 (𝑥 = 0, 𝑥=0.05)
Authors: Eremina R. M. , Yatsyk I. V. , Seidov Z. Y. , Vagizov F. G. , Shustov V. A. , Badelin A. G. , Karpasyuk V. K. , Abdinov D. S. , Tagiev M. M. , Estemirova S. Kh. , von Nidda H.-A. Krug 
Published: August 2022

Abstract
Magnetic properties of polycrystalline La0.81Sr0.19Mn0.9Fe0.1−𝑥Zn𝑥O3 (𝑥 = 0, 0.05) have been investigated by means of electron spin resonance, magnetic susceptibility, and Mössbauer measurements. Both samples show a clear ferromagnetic transition. The Curie temperature 𝑇C decreases on increasing Fe content. Mössbauer studies indicate that Fe in these compounds is in the trivalent high-spin state. The temperature evolution of the Mössbauer spectra at low temperatures (𝑇 < 𝑇C) is typical for ferromagnetic clusters with a wide distribution in size and magnetic correlation length. The inverse susceptibility of all the samples deviates from the Curie– Weiss law above 𝑇C, indicating the presence of fluctuations on approaching magnetic order. An anomalous downturn of the inverse susceptibility for 𝑥 = 0.05 significantly above 𝑇C and the concomitant observation of ferromagnetic resonance signals coexisting with the paramagnetic resonance up to approximately room temperature, is caused by a Griffiths-like behavior. This regime is characterized by the coexistence of ferromagnetic entities within the globally paramagnetic phase.
comparison of the root canal cleaning efficacy of three irrigation methods, XP-endo Finisher, EDDY, and PUI at different apical sizes: an in vitro study
Authors: Zheng Zhiguo , Cai Xiao , Hu Qi , Lu Yukang , Jiao Yutao , zhang Xiaoqin 
Published: August 2022

Abstract
Objectives To compare the effects of three irrigation methods (Passive Ultrasonic Irrigation (PUI), EDDY, and XP-endo Finisher (XPF)) in removing the smear layer of the curving root canals under different apical sizes.Material and methods Seventy-two mesial roots of mandibular molars were divided into nine groups according to different apical sizes and the irrigation protocols: group A1 (size 25, EDDY), group A2 (size 25, XPF), and group A3 (size 25, PUI); group B1 (size 30, EDDY),group B2 (size 30, XPF), and group B3 (size 30, PUI); group C1(size 35, EDDY),group C2 (size 35, XPF), and group C3 (size 35,PUI).The irrigation effect was evaluated by scanning electron microscopy at ×3000 magnification using a 5-point scoring system and statistically analyzed by Kruskal-Wallis and Mann-Whitney tests. Results The application of PUI in mandibular molars should be prepared with the apical size of at least size 35(P＜0.05), and that of EDDY and XPF should only be prepared to size 25(P＜0.05).Conclusion Irrespective of the irrigation activation methods,none could completely remove the smear layer,while EDDY and XPF have a better cleaning effect than PUI under smaller apical size.Clinical relevance EDDY and XPF can be used as safer and more efficient irrigation activation devices.
Tongue depressor-assisted FDG PET/CT scans in oral cancer: a prospective study with a feasibility protocol
Authors: Wang Keh-Bin , Lin Yi-Ching , Kok Victor C. , Lai Jen-Tsung , Wang Hsin-Yi , Liu Ken-Liao , Tsai Shih-Chuan 
Published: August 2022

Abstract
Background
F-18 Fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET/CT) is a powerful tool in oral cancer. However, the oral cavity is a small cavity with complex components. An invasive cancer or post-therapy change frequently cause difficulty in interpretation. In this study, we established a tongue depressor (TD)-assisted FDG PET/CT protocol to solve this problem.
Methods
We enrolled 264 patients with oral cancers. Early and delayed images were acquired in each FDG PET/CT examination. A wooden tongue depressor was placed either between buccal mucosa and teeth or between tongue border and teeth in delayed image. TD placed delayed image was compared with early images to analyze the extent of tumor. The discrimination ratio (DR) of the tumor was calculated as: (images that can clearly distinguish features /all images) × 100%.
Results
In tongue cancer group, the DR of the tumors were 26.1% on early images and 99.3% on TD placed delayed images (p < 0.001). In buccal cancer group, the DR of the tumors were 10.9% on early images and 98.2% on TD placed delayed images (p < 0.001).
Conclusions
The TD-assisted FDG PET/CT protocol is patient-friendly and effective in analyzing the tumor when evaluating oral cancer.
Change of monocytes/macrophages in ulcerative colitis patients with symptoms of anxiety and depression
Authors: Gao Xin , Duan Shihao , Cao Yubin , Zhang Yan 
Published: August 2022

Abstract
Background and aims:
Monocytes/Macrophages play important roles in Inflammatory bowel disease and depression, but few studies had focused on the change of monocytes/macrophages in ulcerative colitis (UC) patients with psychiatric disorders.
Methods
UC patients were divided into two groups based on the Hospital Anxiety and Depression Scale (HADS). Demographic and clinical data were captured. Peripheral blood samples and intestinal biopsies were collected for the analysis of monocyte immunophenotype, phagocytic function, and CD4 + T cell differentiation. Transmission electron microscopy was used to observe the ultrastructure of intestinal macrophages.
Results
A total of 139 UC patients were included. 37.41% and 32.37% of UC patients had symptoms of anxiety and depression. In patients with symptoms of anxiety/depression, mayo score, platelet count, erythrocyte sedimentation rate, and endoscopic score, histological scores were significantly higher than those in UC patients without. In patients with symptoms of anxiety/depression, the percentages of CD14 + + CD16 + monocytes and CD14 + CD16 + + monocytes were higher, and the phagocytosis was decreased. Patients with symptoms of anxiety/depression had more CD68 + cells and higher M1/M2 ratios in the intestine mucosal layer compared to those without.
Conclusions
Monocytes and intestinal macrophages from UC patients with anxiety/depression tended to polarize to pro-inflammatory subtypes, and their function was also impaired.
Determine a proper protocol for routine 18F-FDG uEXPLORER Total-Body PET/CT scan
Authors: Hu Huiran , Huang Yanchao , Sun Hongyan , Zhou Kemin , Jiang Li , Zhong Jinmei , Chen Li , Wang Lijuan , Han Yanjiang , Wu Hubing 
Published: August 2022

Abstract
Background
The axial length of a conventional PET/CT scanner is about 15–30 cm. However, uEXPLORER Total-Body PET/CT has an ultra-long axial field of view of 194 cm. By taking full use of all the scintillation photons, uEXPLORER has a 40 times higher sensitivity for photon detection relative to the conventional PET/CT. Ordered subset expectation maximization (OSEM) is a commonly used iterative algorithm in PET, however, it has a limitation that the image noise will increase when large number iteration is selected. A new penalized-likelihood iterative PET reconstruction, termed HYPER Iterative, was invented and now is available on the uEXPLORER Total-Body PET/CT. To date, its impact in lesion conspicuity in the patients with full injected dose or half injected dose was unclear. The goal of this study is to determine a proper protocol for routine 18F-FDG uEXPLORER Total-Body PET/CT scan.
Results
The quality of the 5 min PET image was excellent (score 5) for all the dose and reconstructed methods. Using the HYPER iterative method, PET image reached the excellent quality at 1 min with full-dose, and at 2 min with half-dose. While PET image reached a similar excellent quality at 2 min with full-dose and 3 min with half-dose using OSEM. The noise in OSEM reconstruction was higher than that by HYPER Iterative. Compared to OSEM, HYPER Iterative had slightly higher SUVmax and TBR of the lesions for large positive lesions (≥ 2cm) (SUVmax: up to 9% higher in full-dose and up to 13% higher in half-dose; TBR: up to 9% higher in full-dose and up to 23% higher in half-dose). For small positive lesions(≤ 10mm), HYPER Iterative had obviously higher SUVmax and TBR of the lesions (SUVmax: up to 45% higher in full-dose and up to 75% higher in half-dose; TBR: up to 45% higher in full-dose and up to 94% higher in half-dose).
Conclusions
Our study demonstrates that 1min scan with full dose and 2 min with half dose is proper for clinical diagnosis using HYPER Iterative, and 2 to 3 min scan for OSEM reconstruction. For detection of the small lesions, HYPER Iterative reconstruction is preferred.
A retrospective study of the safety and immunogenicity of MVC-COV1901 vaccine for people living with HIV
Authors: Cheng Shu-Hsing , Lien Chia En , Hsieh Szu-Min , Cheng Chien-Yu , Liu Wang-Da , Lo Ching-Lung , Ko Wen-Chien , Chen Yen-Hsu , Huang Ching-Tai , Chang Hsiao-Ting , Hwang Shinn-Jang , Wang Ning-Chi , Liu Ming-Che , Lee Yu-Lin , Tai I-Chen , Estrada Josue Antonio Garcia , Lin Tzou-Yien , Lee Wen-Sen 
Published: August 2022

Abstract
Safety and immunogenicity of MVC-COV1901, a recombinant COVID-19 protein vaccine, containing S-2P protein adjuvanted with CpG 1018 and aluminium hydroxide, was assessed for people living with HIV (PWH). A total of 57 PWH of ≥ 20 years of age who are on stable antiretroviral therapy were compared with 882 HIV-negative participants. Participants received 2 doses of MVC-COV1901 28 days apart. No vaccine-related serious adverse events (SAEs) were recorded. Seroconversion rates (SCRs) of 100% and 99.8% were achieved in PWH and comparators, respectively, 28 days after second dose. After adjusting for sex, age, BMI category, and comorbidity, the adjusted GMT ratio of comparator/PWH was 3.2 (95% CI 2.5-4). A higher CD4/CD8 ratio was associated with a higher GMT (R = 0.27, p = 0.039). MVC-COV1901 has shown robust safety but elicited weaker immune responses in PWH. As a result, a third dose or booster doses of MVC-COV1901 may be appropriate for PWH.ClinicalTrials.gov registration: NCT04695652.
Quality assessment of malaria microscopic diagnosis at the LPM-HALD of Dakar, Senegal, in 2020.
Authors: GARBA Mamane Nassirou , DEME Awa Bineta , DIALLO Mamadou Alpha , DIEDHIOU Younous , MBAYE Amadou M. , DIA Mareme , SECK Anna , ZOUMAROU Daba , NDIAYE Yaye D. , NDIAYE Lamine , NDIAYE Tolla , DIONGUE Khadim , SECK Mame Cheikh , NDIAYE Mouhamadou , BADIANE Aida S. , NDIAYE Daouda 
Published: August 2022

Abstract
Background
Following WHO guidelines, microscopy is the reference for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation. In this perspective, we proceeded to laboratory verification through assessing the performance of the laboratory by confirming the reliability and the accuracy of the results obtained in accordance with the requirements of the ISO 15189 standards. This study aimed to verify the method of microscopic diagnosis of malaria at the LPM, in the Aristide Le Dantec hospital (HALD) in Dakar, Senegal.
Methods
This is a validation/verification study conducted from June to August 2020. Twenty (20) microscopic slides of thick/thin smear with known parasite densities (PD) selected from the Cheick Anta Diop University malaria slide bank in Dakar were used for this assessment. Six (6) were used to assess readers' ability to determine PD and fourteen (14) were used for detection and identification of parasites. Four (4) LPM-HALD microscopists read and recorded their results on prepared sheets. Data analysis was done with Microsoft Excel 2010 software.
Results
Of these twenty (20) slides read, a 100% agreement was obtained on eight (8) slides. Four (4) out of the six (6) parasite density evaluation slides obtained a concordance of less than 50%. Thirteen (13) out of the fourteen (14) identification slides obtained a concordance greater than 50%. Only one (1) identification slide obtained zero agreement from the readers. On the other hand, for species identification it was noted a score greater than 80% and the PD obtained a score between 0.20 and 0.4. Readers obtained 100% precision, sensitivity, specificity and both negative and positive predictive values.
Conclusion
This work demonstrated that the microscopic method of malaria diagnosis used in the LPM/HALD are in accoradance with all the reliability required by ISO 15189.
Functional architecture of M1 cells encoding movement direction
Authors: MAZZETTI Caterina , SARTI Alessandro , Citti Giovanna 
Published: August 2022

Abstract
In this paper we propose a neurogeometrical model for the behaviour of cells of the arm area of the primary motor cortex (M1). From Georgopoulos neural models [31, 29], we will provide a fiber bundle structure which is able to describe the hypercolumnar organization of the cortical area. On this structure, we will consider the selective tuning of M1 neurons of kinematic variables of positions and directions of movement. We will then extend this model to encode the direction of arm movement which varies in time, as experimentally measured by Hatsopoulos [37] by introducing the notion of movement fragments. This leads to consider a higher dimensional geometrical structure where fragments will be represented as integral curves. A fitting of parameters with neurophysiological data will be described, and a comparison with the curves obtained through numerical simulations and experimental data will be presented. Finally, we will compare our model with the area of V1 responsible for movement coding, which exhibits analogous time-dependent receptive profiles.
Cigarette smoke and tumor micro-environment co-promote aggressiveness of human breast cancer cells
Authors: Benoit Louise , Tomkiewicz Celine , Delit Maxime , Khider Hanna , Audouze Karine , Kowandy Flavie , Bortoli Sylvie , Barouki Robert , Coumoul Xavier , Koual Meriem 
Published: August 2022

Abstract
The role of the environment in breast cancer (BC) progression has recently been suggested. We aimed to assess if a mixture of pollutants, cigarette smoke, could favor its aggressivity. We also evaluated the impact of the micro-environment, largely represented by adipocytes, in mediating this.BC cells lines MCF-7 were cultured using a transwell co-culture model with preadipocytes hMADS cells or were cultured alone. Cells were treated by cigarette smoke extract (CSE) and the four conditions: control, CSE, co-culture and co-exposure (co-culture and CSE) were compared. We analyzed morphological changes, cell migration, resistance to anoikis, stemness, epithelial to mesenchymal transition (EMT) and presence of hormonal receptors in each condition. A complete transcriptomic analysis was carried out to highlight certain pathways.Several hallmarks of metastasis were specific to the coexposure condition (cell migration, resistance to anoikis, stemness) whereas others (morphological changes, EMT, loss of hormonal receptors) could be seen in the coculture condition and were aggravated by CSE (coexposure). Moreover, MCF-7 cells presented a decrease in hormonal receptors, suggesting an endocrine treatment resistance. These results were confirmed by the transcriptomic analysis. Our in vitro results suggest that a common mixture of pollutants could promote BC metastasis in a co-culture model.
CuFe 2 O 4 @SiO 2 @L-arginine@Cu(I) as a new magnetically retrievable heterogeneous nanocatalyst with high efficiency for 1,4-disubstituted 1,2,3-triazoles synthesis
Authors: Salehzadeh Fatemeh , Esmkhani Maryam , Zallaghi Mahsa , Javanshir Shahrzad , Dekamin Mohammad G. 
Published: August 2022

Abstract
A novel magnetic heterogeneous catalyst was synthesized through the immobilization of copper ions onto the l-arginine functionalized CuFe2O4@SiO2. The prepared catalyst was characterized by Fourier Transform Infrared (FT-IR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), and Energy Dispersive X-Ray spectroscopy (EDX). The resulting catalyst was used in the ultrasonic-assisted synthesis of 1,2,3-triazoles via a one-pot three-component reaction of alkynes, alkyl halides, and sodium azides under green conditions within a short time. The catalyst reusability was investigated after five cycles and no significant loss of activity was observed.
Agility, digitalization, and localization: a framework for supply chain resilience
Authors: Thekkoote Ramadas 
Published: August 2022

AbstractThe epidemic of COVID-19 exposed companies to the failure of typical manufacturing and consumption patterns and their long-term effects on supply chains. This conceptual paper discusses localization, agility, and digitalization factors that make the supply chain more resilient. From a theoretical perspective, this research intends to investigate how these characteristics interact to assist the supply chain in becoming resilient by using digitalization, localization, and agility as enablers through conceptual models.The methodology used in this study is an exploratory conceptual investigation to cover the theoretical gaps. A critical evaluation of the literature was conducted to develop a conceptual model to ascertain the current state of knowledge regarding the relationship between supply chain resilience, localization, agility, and digitization in management practice. The study's primary data are the responses to questionnaires issued to respondents, analyzed, and hypotheses were formed and tested using the structural equation modeling technique. The result indicates that agility, localization, and digitalization positively impact supply chain resilience. Additionally, the industry's size and type positively impact the supply chain resilience as a control variable.As a result of the research, a new understanding of supply chain resilience emerges that can assist firms to gain new possibilities to develop new ways to do business under stress.
Language Models Learn Sentiment and Substance from 11,000 Psychoactive Experiences
Authors: Friedman Sam , Ballentine Galen 
Published: August 2022

Abstract
With novel hallucinogens poised to enter psychiatry, we lack a unified framework for quantifying which changes in consciousness are optimal for treatment. Using transformers (i.e. BERT) and 11,816 publicly-available drug testimonials, we first predicted 28-dimensions of sentiment across each narrative, validated with psychiatrist annotations. Secondly, BERT was trained to predict biochemical and demographic information from testimonials. Thirdly, canonical correlation analysis (CCA) linked 52 drugs' receptor affinities with testimonial word usage, revealing 11 latent receptor-experience factors, mapped to a 3D cortical atlas. Together, these 3 machine learning methods elucidate a neurobiologically-informed, temporally-sensitive portrait of drug-induced subjective experiences. Different models’ results converged, revealing a pervasive distinction between lucid and mundane phenomena. MDMA was linked to "Love", DMT and 5-MeO-DMT to "Mystical Experiences", and other tryptamines to "Surprise", "Curiosity" and "Realization". Applying these models to real-time biofeedback, practitioners could harness them to guide the course of therapeutic sessions.
Porphyrin-based porous organic frameworks as efficient peroxidase mimics for selective detection of hydrogen peroxide and glucose
Authors: Wang Feiyan , Liao Linhong , Zhang Quanquan , Luo Xiaogang , Li Wei , Wu Fengshou 
Published: August 2022

Abstract
Glucose is regarded as a clinical biomarker, and the abnormal level of glucose in blood would cause endocrine metabolic diseases. Thus, it is of great significance to develop a simple, accurate, and sensitive method for glucose detection. In this work, we synthesized an iron porphyrin-based porous organic framework (Fe-POF) through a facile alkylation reaction between 5,10,15,20-tetra(4-aminophenyl) porphyrin (TAPP) and cyanuric chloride. Fe-POF exhibited excellent peroxidase-like activity and could be used to detect hydrogen peroxide and the molecules associated with hydrogen peroxide such as glucose. The structure of Fe-POF was confirmed through a series of methods, such as FT-IR, SEM, EDS, TEM, and XPS. Fe-POF exhibited excellent peroxidase-like activity, which could catalyze the oxidization of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue product (ox-TMB) in the presence of hydrogen peroxide (H2O2). Based on this phenomenon, a simple colorimetric assay was constructed for the detection of H2O2 and glucose with high selectivity and sensitivity. The detection limit of H2O2 and glucose was calculated to be 1.8 and 1.39 µM, respectively. Finally, Fe-POF was applied as a colorimetric sensor for rapid detection of glucose in diluted serum samples.