bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives of COVID‐19 vaccine–hesitant emergency department patients to inform messaging platforms to promote vaccine uptake
Authors: Gentsch Alexzandra T. , Butler Jonathan , O'Laughlin Kelli , Eucker Stephanie A. , Chang AnnaMarie , Duber Herbie , Geyer Rachel E. , Guth Amanda , Kanzaria Hemal K. , Pauley Alena , Rising Kristin L. , Chavez Cecilia Lara , Tupetz Anna , Rodriguez Robert M. 
Published: October 2022

AbstractObjectivesEfforts to promote COVID‐19 vaccine acceptance must consider the critical role of the emergency department (ED) in providing health care to underserved patients. Focusing on patients who lacked primary care, we sought to elicit the perspectives of unvaccinated ED patients regarding COVID‐19 vaccination concerns and potential approaches that might increase their vaccine acceptance.MethodsWe conducted this qualitative interview study from August to November 2021 at four urban EDs in San Francisco, California; Seattle, Washington; Durham, North Carolina; and Philadelphia, Pennsylvania. We included ED patients who were ≥18 years old, fluent in English or Spanish, had not received a COVID‐19 vaccine, and did not have primary care physicians or clinics. We excluded patients who were unable to complete an interview, in police custody, under suspicion of active COVID‐19 illness, or presented with a psychiatric chief complaint. We enrolled until we reached thematic saturation in relevant domains. We analyzed interview transcripts with a content analysis approach focused on identifying concerns about COVID‐19 vaccines and ideas regarding the promotion of vaccine acceptance and potential trusted messengers.ResultsOf 65 patients enrolled, 28 (43%) identified as female, their median age was 36 years (interquartile range 29–49), and 12 (18%) interviews were conducted in Spanish. Primary concerns about COVID‐19 vaccines included risk of complications, known and unknown side effects, and fear of contracting COVID‐19 from vaccines. Trust played a major role for patients in deciding which sources to use for vaccine information and in engendering vaccine acceptance. Health care providers and family or friends were commonly cited as trusted messengers of information.ConclusionsWe characterized concerns about COVID‐19 vaccines, uncovered themes that may promote vaccine acceptance, and identified trusted messengers—primarily health care professionals. These data may inform the development of nuanced COVID‐19 vaccine messaging platforms to address COVID‐19 vaccine hesitancy among underserved ED populations.
Circ_0031027 adjusts the advancement of cervical cancer by miR‐587/SOCS5 axis
Authors: Chen Yajun , Yang Yuanju , Wang Shuang , Guan Fujuan , Zhen Shenghua 
Published: October 2022

AbstractBackgroundCircular RNAs (circRNAs) might participate in the growth of cervical cancer (CC). In this research, we reconnoitered the characters of circ_0031027 in CC.MethodsCirc_0031027, microRNA‐587 (miR‐587), and suppressor of cytokine signaling 5 (SOCS5) abundances were distinguished by qRT‐PCR and western blot. The cell functions were examined by colony formation assay, EdU assay, and transwell assay. The combined relationship of miR‐587 and circ_0031027 or SOCS5 was identified by dual‐luciferase reporter assay. Ultimately, the mice test was utilized to assess the part of circ_0031027.ResultsCirc_0031027 and SOCS5 were downregulated, and the miR‐587 was upregulated in CC. For functional analysis, circ_0031027 overexpression repressed cell proliferation, cell migration, and invasion in CC cells. Circ_0031027 as a miR‐587 sponge to adjust SOCS5. MiR‐587 facilitated the advancement of CC cells by overturning SOCS5. In addition, circ_0031027 overexpression subdued tumor growth.ConclusionCirc_0031027 inhibited the enlargement of CC by miR‐587/SOCS5.
In vitro analysis of factors affecting the continuous hemodiafiltration clearance of teicoplanin
Authors: Sawada Mifuyu , Uchida Masashi , Yamazaki Shingo , Suzuki Tatsuya , Suzuki Takaaki , Ishii Itsuko 
Published: October 2022

AbstractBackgroundIn the treatment of sepsis, continuous hemodiafiltration (CHDF) and the administration of antibiotics such as teicoplanin (TEIC) are frequently performed in parallel. We aimed to clarify the factors influencing the CHDF clearance (CLCHDF) of TEIC using a polymethylmethacrylate (PMMA) membrane or a polyacrylonitrile and sodium methallyl sulfonate copolymer membrane coated with polyethylenimine (AN69ST). We also investigated whether the adsorption of TEIC onto the hemofilters inhibits the adsorption of interleukin (IL)‐6 onto the membranes.MethodsTEIC, human serum albumin (HSA), and IL‐6 were incubated with pieces of hemofilter membranes and adsorption rates were calculated. The CLCHDF, diafiltration rate, and adsorption rate of TEIC were calculated using an in vitro CHDF circuit model.ResultsThe adsorption rates of TEIC onto the pieces of PMMA and AN69ST membranes ranged from 15.0% to 100% and from −10% to 5%, respectively. The adsorption rate of IL‐6 was similar with or without TEIC. The CLCHDF and adsorption rate of TEIC under PMMA‐CHDF depended on HSA, but not on effluent flow rate (Qe). The CLCHDF under AN69ST‐CHDF depended on HSA and Qe. The observed CLCHDF under AN69ST‐CHDF was similar to the predicted value (the product of Qe and the plasma unbound fraction). The observed CLCHDF under PMMA‐CHDF was 2.0–7.8 times greater than the predicted value.ConclusionsAdsorption mainly contributes to the CLCHDF of TEIC using PMMA membranes, whereas diafiltration mainly contributes to the CLCHDF of TEIC using AN69ST membranes. TEIC adsorption might not affect the adsorption of IL‐6 onto PMMA membrane.
Longitudinal causal relationship between depression and self‐esteem in Korean older adults
Authors: Wang Juanjuan , Hoe Maanse 
Published: October 2022

AbstractThis study aimed to examine the longitudinal causal relationship between depression and self‐esteem (SE) in older Koreans and analyze gender differences in this correlation. Participants were 4742 older adults aged ≥65 years in baseline 2018 from the Korea Welfare Panel Study. Depression and SE were measured every year from 2018 to 2021. This study estimated causal relationships using the autoregressive cross‐lagged model and analyzed gender differences using a multigroup approach. The findings indicate that depression and SE in older adults support the reciprocal causal model, but there are no gender differences. The study recommends that both depression and SE should be considered in the design of social work intervention programs for older adults but can disregard gender differences.
Musculature of the male abdominal segments and terminalia of Zaphne barbiventris (Zetterstedt, 1845) and Delia fabricii (Holmgren, 1872) (Diptera: Anthomyiidae)
Authors: Ovtshinnikova Olga. G. , Sorokina Vera S. 
Published: October 2022

AbstractThe abdominal and pregenital segments and genitalia were studied in males of Zaphne barbiventris (Zetterstedt, 1845) and Delia fabricii (Holmgren, 1872) (Anthomyiidae). The examined species are very similar in the structure of the sclerites and muscles of their terminal segments. Differences between Delia Robineau‐Desvoidy, 1830 and Zaphne Robineau‐Desvoidy, 1830 were found only in the structure of the pregenital segments and their muscles. Delia has well‐developed and well‐identified tergite VI, while tergite VI of Zaphne is fused in syntergosternite VI + VII + VIII as indicated by the insertion of muscles of ITM 5 running from tergite V. Within members of the muscoid grade, the skeleton and musculature of male terminalia of the Anthomyiidae were similar to that in the subfamily Azeliinae of the Muscidae and the Scathophagidae. The complete set of phallapodeme muscles, as well as the complete set of muscles of the pregenital sclerites and the position of cercal muscles M 26, has shown that the Anthomyiidae have more plesiomorphic character states than other members of the muscoid grade. Descriptions and figures of the terminal sclerites and muscles of Zaphne barbiventris are provided.
A systematic review of the barriers and facilitators to adherence to mindfulness‐based cognitive therapy for those with chronic conditions
Authors: Marks Eleanor , Moghaddam Nima , De Boos Danielle , Malins Sam 
Published: October 2022

AbstractPurposeMindfulness‐Based Cognitive Therapy (MBCT) can improve the lives of those with a chronic condition and psychological distress, however, high drop‐out rates limit benefits. MBCT might be a candidate treatment for this population if nonadherence can be overcome. This review explores the existing literature on the barriers and facilitators to adherence to MBCT for those with chronic conditions.MethodDatabases MEDLINE, PsycINFO, CINAHL and Scopus were searched between 28th May and 11th June 2021. We included empirical papers that identified barriers and/or facilitators to MBCT adherence in patients with chronic conditions—excluding non‐English and grey literature. Papers were screened and duplicates removed. Extracted data included: setting, design, aim, sample‐size, population and identified barriers/facilitators to MBCT adherence. The Mixed Methods Appraisal Tool (MMAT) was adapted and used to appraise the quality of studiesResultsTwenty papers were eligible for review. Synthesis identified six themes (in prevalence order): (1) Practical Factors (e.g., time and other commitments), (2) Motivation (e.g., change‐readiness), (3) Patient clinical and demographic characteristics (e.g., current physical health), (4) Connection with Others (facilitators and group members), (5) Credibility (perception of the intervention) and (6) Content difficulty (intervention accessibility). Findings highlight potential adaptations to implementation (e.g., clear treatment rationale, preference matching, and eliciting and responding to individual concerns or obstructive assumptions) that could address barriers and harness facilitators.ConclusionThis review contributes a higher order understanding of factors that may support/obstruct client adherence to MBCT with implications for future implementation in research and practice. Future research should prioritize open exploration of barriers/facilitators.
A snapshot of protein trafficking in SARS‐CoV‐2 infection
Authors: Prasad Vibhu , Bartenschlager Ralf 
Published: October 2022

AbstractSARS‐CoV‐2 is a human pathogenic virus responsible for the COVID‐19 (coronavirus disease 2019) pandemic. The infection cycle of SARS‐CoV‐2 involves several related steps, including virus entry, gene expression, RNA replication, assembly of infectious virions and their egress. For all of these steps, the virus relies on and exploits host cell factors, cellular organelles, and processes such as endocytosis, nuclear transport, protein secretion, metabolite transport at membrane contact sites (MSC) and exocytotic pathways. To do this, SARS‐CoV‐2 has evolved multifunctional viral proteins that hijack cellular factors and modulate their function by unique strategies. In this Review, we highlight cellular trafficking factors, processes, and organelles of relevance to the SARS‐CoV‐2 infection cycle and how viral proteins make use of and perturb cellular transport during the viral infection cycle.
Machine learning‐based prediction of mortality after heart transplantation in adults with congenital heart disease: A UNOS database analysis
Authors: Kampaktsis Polydoros N. , Siouras Athanasios , Doulamis Ilias P. , Moustakidis Serafeim , Emfietzoglou Maria , Van den Eynde Jef , Avgerinos Dimitrios V. , Giannakoulas George , Alvarez Paulino , Briasoulis Alexandros 
Published: October 2022

AbstractBackgroundMachine learning (ML) is increasingly being applied in Cardiology to predict outcomes and assist in clinical decision‐making. We sought to develop and validate an ML model for the prediction of mortality after heart transplantation (HT) in adults with congenital heart disease (ACHD).MethodsThe United Network for Organ Sharing (UNOS) database was queried from 2000 to 2020 for ACHD patients who underwent isolated HT. The study cohort was randomly split into derivation (70%) and validation (30%) datasets that were used to train and test a CatBoost ML model. Feature selection was performed using SHapley Additive exPlanations (SHAP). Recipient, donor, procedural, and post‐transplant characteristics were tested for their ability to predict mortality. We additionally used SHAP for explainability analysis, as well as individualized mortality risk assessment.ResultsThe study cohort included 1033 recipients (median age 34 years, 61% male). At 1 year after HT, there were 205 deaths (19.9%). Out of a total of 49 variables, 10 were selected as highly predictive of 1‐year mortality and were used to train the ML model. Area under the curve (AUC) and predictive accuracy for the 1‐year ML model were .80 and 75.2%, respectively, and .69 and 74.2% for the 3‐year model, respectively. Based on SHAP analysis, hemodialysis of the recipient post‐HT had overall the strongest relative impact on 1‐year mortality after HΤ, followed by recipient‐estimated glomerular filtration rate, age and ischemic time.ConclusionsML models showed satisfactory predictive accuracy of mortality after HT in ACHD and allowed for individualized mortality risk assessment.
Canopy nitrogen addition affects ground‐dwelling spider assemblages and trophic position
Authors: Liu Shengjie , Meng Yuanyuan , Behm Jocelyn E. , Zhang Wei , Fu Shenglei 
Published: October 2022

Abstract
While it is clear that nitrogen (N) deposition impacts the plant diversity of major terrestrial ecosystems, how ground‐dwelling fauna respond to N deposition is less understood.
Here, we use a novel experimental methodology of canopy addition of N (CAN) to simulate realistic N deposition and contrast this method to standard understory addition of N (UAN) in a temperate forest and a subtropical forest. We investigated the shifts in community composition and trophic position for ground‐dwelling spiders under different N deposition treatments.
We found that the CAN deposition treatment increased the diversity of sit‐and‐wait spiders and the abundance of actively hunting spiders at the subtropical forest, but N treatments had no effect on spider abundance or diversity at the temperate forest. In contrast, UAN treatments had no significant impact on spider communities compared to control treatment. Furthermore, N treatments had significant effects on spider assemblage at subtropical forest. Overall, spiders in the CAN treatment had a higher trophic position as indicated by δ15N isotopic signatures at both forest types.
In conclusion, our study suggests that the effects of N deposition on ground‐dwelling spider assemblages depend on N addition approaches. Furthermore, our results suggest that CAN is a more realistic method for understanding the effects of atmospheric N deposition on soil arthropods in forest ecosystems.
Synthesis of silver core‐shell nanoparticles and their influence on an experimental resin endodontic sealer: An in vitro analysis
Authors: Rücker Victória Britz , Balbinot Gabriela de Souza , Collares Fabrício Mezzomo , de Araújo Neto Vitaliano Gomes , Giannini Marcelo , Leitune Vicente Castelo Branco 
Published: October 2022

AbstractAimTo avoid root canal recontamination and endodontic treatment failure, endodontic sealers with antibacterial activity could be an alternative. Silver nanoparticles have antibacterial activity and this study aimed to synthesize Ag@SiO2 nanoparticles, incorporate them into an experimental endodontic resin sealer and evaluate their influence on physicochemical and biological properties.MethodologyAg@SiO2 nanoparticles were produced using the sol–gel process, based on the Stöber method. The particles were characterized in terms of their chemical structure by Fourier transform‐infrared spectroscopy (FTIR), X‐ray diffraction (XRD), thermogravimetric analysis (TGA), UV–Vis spectral analysis, scanning electron microscopy, and transmission electron microscopy, where the particle morphology and diameter were analysed. A dual‐cured experimental endodontic resin sealer was formulated using 70 wt% UDMA, 15 wt% GDMA, and 15 wt% BisEMA. The photoinitiators were added separately in two pastes. The Ag@SiO2 nanoparticles were incorporated into the endodontic sealer at the concentrations of 2.5 wt%, 5 wt%, and 10 wt%, and a control group without nanoparticles was also formulated. The endodontic sealers were evaluated for their flow, film thickness, degree of conversion, softening in solvent, radiopacity, cytotoxicity and antibacterial activity immediately and after 9 months in water storage.ResultsSilver was detected in the chemical characterization of Ag@SiO2 that presented a spheric regular shape and average 683.51 nm ± 93.58 diameter. Sealers presented adequate flow and film thickness while radiopacity values were below the ones required by ISO 6876. All groups underwent softening after immersion in a solvent. The 10 wt% groups showed a higher loss of subsurface hardness (∆KHN%). No reduction in cell viability was observed. Enterococcus faecalis viability in biofilm was reduced in 10 wt% groups after 24 h and 9 months.ConclusionThe addition of 10 wt% Ag@SiO2 reduced E. faecalis viability at immediate and longitudinal analysis while maintaining the physicochemical properties of developed sealers.
Selenium ameliorates inflammation by decreasing autophagic flux and mitogen‐activated protein kinase signalling on experimentally induced rat periapical lesions
Authors: Bolat Nergiz , Erzurumlu Yalçin , Aşcı Halil , Özmen Özlem , Üreyen Kaya Bulem 
Published: October 2022

AbstractAimTo reveal the molecular mechanisms that targets mitogen‐activated protein kinase (MAPK) signalling and the autophagic flux and to investigate the possible effects of the systemic administration of selenium (Se) on experimentally induced rat periapical lesions.MethodologyThirty adult Sprague–Dawley rats were divided equally into negative control, positive control and Se groups. In the positive control and Se groups, the pulp chambers of their mandibular first molars were exposed to the oral environment to induce periapical lesions The Se group received daily intraperitoneal injections of Se at a dose of 0.1 mg kg−1. After 28 days, the amount of bone destruction; severity of inflammation; penetration of microorganisms along the root canal; collagen degradation in periodontal ligament; interleukin (IL)‐6, hypoxia‐inducible factor‐1 (HIF‐1), cyclooxygenase‐2 (COX‐2) and caspase‐3 expression; autophagic flux; and p38 MAPK signalling were evaluated using radiographic, histopathological, Gram staining, picrosirius red stain, immunohistochemical, quantitative real‐time polymerase chain (qRT–PCR) and Western blot methods, respectively. These data were analysed through the Kruskal–Wallis and Dunnett's tests (p < .05).ResultsThe area of radiographic periapical bone loss, histopathological scores, the area of periapical bone loss and the scores for the bacteria localisation, the intensity of immunohistochemical staining for IL‐6, HIF‐1, COX‐2 and caspase‐3 in the Se group was significantly less than those of the positive control group (p < .01). The mRNA expression levels of Beclin‐1, Atg3, Atg5, Atg7 and Atg16L1 were lower in the Se group than in the positive control group (p < .01). The protein expressions of Beclin‐1, Atg5 and LC3‐II, the phosphorylation ratio of the p38 MAPK and the ratios of LC3II/LC3I were significantly higher (p < .05) in the positive control and Se groups. On the contrary, the expression of the p62/SQSTM1 protein was significantly lower (p < .05) in the positive control and Se groups than in the negative control group.ConclusionThe induction of periapical lesions in rats increased autophagic flux and activated p38 MAPK signal transduction processes. Se suppressed the inflammatory process, reduced bone destruction and both the autophagic flux and p38 MAPK activation.
Concept analysis of adolescent use of social media for emotional well‐being
Authors: Jo Soojung , Jang Mi Young 
Published: October 2022

AbstractAimThe aim of the study is to conduct a concept analysis of adolescents' emotional well‐being resulting from healthy social media use.BackgroundAdolescents are the group that uses mobile social media the most. They connect to others and achieve life satisfaction via social media. Here, we consider both the positive and negative aspects of social media use and recognize the need for clear guidance on proper social media use among adolescents.DesignThis study utilized an eight‐step method of concept analysis.Data sourcesA systematic literature search of PubMed, CINAHL and PsycInfo was conducted, and 10 articles were selected.Review methodsWe defined attributes, model cases, antecedents, consequences and referents.ResultsThe attributes of adolescent emotional well‐being on social media are (a) relationships with others, (b) internet‐based communication and (c) being happy and maintaining emotional health. Adolescents use social media to feel safe, seek information and connect to others. Adolescents reported having better relationships and positive affect as a result of social media use.ConclusionThis concept analysis will help health‐care providers understand how adolescent emotional well‐being is attained through social media. Additionally, this study will provide the basis of behavioural theories and future interventions that guide adolescent use of social media.
Initiating value‐based healthcare in psoriasis: Proposing a value‐based outcome set for daily clinical practice
Authors: Hilhorst Niels Timo , Deprez Elfie , Balak Deepak Mukesh Wieshwaykumar , Van Geel Nanja , Gutermuth Jan , Hoorens Isabelle , Lambert Jo Lydie Wilfried 
Published: October 2022

AbstractBackgroundWith the current trend in healthcare moving towards a more value‐based approach, it is essential to understand what value encompasses.ObjectivesTo develop an actionable value‐based outcome set (VOS) for daily practice.MethodsA mixed method approach was used consisting of four phases. Formerly, a systematic review was conducted, providing an overview of all patient‐relevant outcomes defined in current literature. These 23 outcomes were then presented to a group of patients, using a modified nominal group technique (NGT), to establish whether these results represented all of their relevant outcomes. Subsequently, these outcomes were ranked according to importance by patients attending our academic specialized psoriasis clinic. A review of the literature was performed to assess which instruments were available and suitable to evaluate the outcomes in this VOS. Finally, a pilot feasibility test was performed amongst patients.ResultsOf the 23 outcomes, two were omitted from the ranking exercise after the NGT. In the ranking exercise, 120 patients participated. The median age was 50.0 (IQR 25.0) years and 36.7% were female. Median PASI score was 2.4 (IQR 5.2), and treatments varied from topicals to biologicals. The outcomes scored as most important were symptom control, treatment efficacy, confidence in care and control of disease. The least important outcomes were comorbidity control, productivity and cost of care. A significant difference was shown between the ranking of the outcomes (p < 0.001). In total, 12 instruments were selected, which are reported by both patient and provider, to measure the outcomes in this VOS. Median completion time for the patient part was 30 min (IQR 2.8).ConclusionsThis VOS is a first proposal to evaluate psoriasis care in a value‐based manner. Measuring these outcomes can enable us to critically appraise and improve current care processes, within the reality of available resources, thereby increasing value for patients.