bluuebunny/crossref_metadata_2025_split huggingface dataset:
C100. Torsades de Pointes (Polymorphic VT) as a Manifestation in Hypothyroid Patient’s: A Case Report
Authors: Akina M T , Muzakkir A 
Published: April 2022

Abstract

Background
Hypothyroidism is a common endocrine disorder with varying abnormalities including cardiac manifestations consisting of structural, functional, and electrical conduction problems especially in severe cases. Torsades de pointes (TdP) is a very rare initial presentation in a patient with hypothyroidism. We report a patient with severe hypothyroidism manifest with life-threatening arrhythmias.

Case Description
A 48-year-old man who underwent emergency resuscitation suffering from cardiac arrest. On admission, the patient collapsed and was unresponsive. Electrocardiography (ECG) showed QT interval prolongation, and polymorphic ventricular tachycardia (TdP). Laboratory test revealed marked hypokalemia (potassium concentration of 2.6 mmol per liter) and unexpected severe hypothyroid (Free T4 (FT4) was &lt;0.07 [normal 0.93-1.71] μg/dl; thyroid-stimulating hormone (TSH) was &gt;60.0 [normal 0.27-4.20] mIU/mL). Temporary cardiac pacing was placed for managing specific arrhythmias. The patient was also treated with levothyroxine 100 μg per day, and the underlying electrolyte disturbance was corrected. Treatment with levothyroxine was continued in outpatient clinic. ECG and thyroid tests were returned to normal limit within six weeks.

Discussion
Clinicians need to highlight that TdP is relatively rare in hypothyroidism. Early diagnosis and prompt management were needed due to potential fatal cardiac manifestation if left untreated. All patients with overt hypothyroidism with TSH &gt;10 mIU/L should be treated. Administration of levothyroxine is a mandatory treatment and should be monitored carefully and safely to eliminate arrhythmias.
C103. Viral Myocarditis Mimicking Acute Myocardial Infarction: A Case Report
Authors: Seriulina R A , Martanto E 
Published: April 2022

Abstract

Background
Acute myocarditis still challenging diagnosis in cardiology. Its entity is rarely recognized and its pathophysiology defectively understood. Viral infection remains the most commonly identified cause for myocarditis, but bacteria, fungi, protozoa, and helminths have also been implicated.

Case Summary
A 61 years old female was admitted to emergency department, complaining typical angina since 12 hours prior to admission. She also complains nausea, vomit, flu like syndrome, and low grade fever since 1 weeks prior to admission. She was a former smoker and had hypertension. ECG in 6 hours on admission ECG revealed sinus rhythm, ST-elevation anteroseptal, ischemic lateral-high lateral and there is no evolution compare to previous ECG which taken in other hospital. Laboratory findings showed increased of troponin enzyme. Coronary angiography was performed with result normal coroner. Echocardiography revealed normal all chambers, concentric LV remodelling, normal LV systolic function with ejection fraction 51% without regional wall motion abnormalities. On the next day, troponin levels decrease and the ECG remain abnormal without any changes. In order to get more data, CMR was planned, but she refused. Patients was discharged uneventful.

Discussion
Myocarditis is challenging diagnosis due to the heterogenicity clinical presentation. It presents in many different ways, ranging from mild “flu-like” symptoms, mild symptoms of chest pain and palpitations associated with transient ECG changes. Chest pain in acute myocarditis may mimic typical angina and be associated with electrocardiographic changes, including ST-segment elevation and often misdiagnosed as ACS until coronary angiography demonstrates normal or non-obstructive coronary arteries.
Integrative multi-omics database (iMOMdb) of Asian pregnant women
Authors: Pan Hong , Tan Pei Fang , Lim Ives Y , Huan Jason , Teh Ai Ling , Chen Li , Gong Min , Tin Felicia , Mir Sartaj Ahmad , Narasimhan Kothandaraman , Chan Jerry K Y , Tan Kok Hian , Kobor Michael S , Meikle Peter J , Wenk Markus R , Chong Yap Seng , Eriksson Johan G , Gluckman Peter D , Karnani Neerja 
Published: April 2022

Abstract
Asians are underrepresented across many omics databases, thereby limiting the potential of precision medicine in nearly 60% of the global population. As such, there is a pressing need for multi-omics derived quantitative trait loci (QTLs) to fill the knowledge gap of complex traits in populations of Asian ancestry. Here, we provide the first blood-based multi-omics analysis of Asian pregnant women, constituting high-resolution genotyping (N = 1079), DNA methylation (N = 915) and transcriptome profiling (N = 238). Integrative omics analysis identified 219 154 CpGs associated with cis-DNA methylation QTLs (meQTLs) and 3703 RNAs associated with cis-RNA expression QTLs (eQTLs). Ethnicity was the largest contributor of inter-individual variation across all omics datasets, with 2561 genes identified as hotspots of this variation; 395 of these hotspot genes also contained both ethnicity-specific eQTLs and meQTLs. Gene set enrichment analysis of these ethnicity QTL hotspots showed pathways involved in lipid metabolism, adaptive immune system and carbohydrate metabolism. Pathway validation by profiling the lipidome (~480 lipids) of antenatal plasma (N = 752) and placenta (N = 1042) in the same cohort showed significant lipid differences among Chinese, Malay and Indian women, validating ethnicity-QTL gene effects across different tissue types. To develop deeper insights into the complex traits and benefit future precision medicine research in Asian pregnant women, we developed iMOMdb, an open-access database.
Activity of fosfomycin/colistin combinations against planktonic and biofilm Gram-negative pathogens
Authors: Boncompagni Selene Rebecca , Micieli Maria , Di Maggio Tiziana , Aiezza Noemi , Antonelli Alberto , Giani Tommaso , Padoani Gloria , Vailati Silvia , Pallecchi Lucia , Rossolini Gian Maria 
Published: April 2022

Abstract

Objectives
To investigate the in vitro activity of fosfomycin, colistin and combinations thereof against planktonic and biofilm cultures of Gram-negative pathogens, mostly showing MDR phenotypes, at concentrations achievable via inhalation of aerosolized drugs.

Methods
Activity against planktonic cultures was tested by the chequerboard assay with 130 strains, including 52 Pseudomonas aeruginosa, 47 Klebsiella pneumoniae, 19 Escherichia coli, 7 Stenotrophomonas maltophilia and 5 Acinetobacter baumannii. Activity against biofilm cultures was tested by biofilm chequerboard and quantitative antibiofilm assays with a subset of 20 strains. In addition, 10 of these strains were tested in mutant prevention concentration (MPC) assays.

Results
Against planktonic cultures, synergism between fosfomycin and colistin was detected with a minority (10%) of strains (eight K. pneumoniae and five P. aeruginosa), while antagonism was never observed. Synergism between fosfomycin and colistin against biofilms was observed with the majority of tested strains (16/20 in biofilm chequerboard assays, and 18/20 in the quantitative antibiofilm assays), including representatives of each species and regardless of their resistance genotype or phenotype. Furthermore, combination of fosfomycin and colistin was found to significantly reduce the MPC of individual drugs.

Conclusions
Fosfomycin and colistin in combination, at concentrations achievable via inhalation of nebulized drugs, showed notable synergy against MDR Gram-negative pathogens grown in biofilm, and were able to reduce the emergence of fosfomycin- and colistin-resistant subpopulations.
Medium-run local economic effects of a major earthquake
Authors: Aguirre Paula , Asahi Kenzo , Diaz-Rioseco Diego , Riveros Ignacio , Valdés Rodrigo O 
Published: April 2022

AbstractExisting research is inconclusive regarding the longer-term economic effects of earthquakes. We examine the medium-run impacts of the 2010 earthquake in Chile, the sixth-largest ever recorded, using value-added tax collection as a proxy for economic activity at the municipal level and a measure of local ground-shaking intensity. We find that the affected municipalities suffered a relevant and persistent drop in their economic activity of about 10%, 8–9 years after the event. We discuss the plausibility of the assumption of conditional parallel trends and show that the overall results are robust to using alternative estimation methods.
Dark secrets of phytomelatonin
Authors: Chen Qi , Hou Suying , Pu Xiaojun , Li Xiaomin , Li Rongrong , Yang Qian , Wang Xinjia , Guan Miao , Rengel Zed 
Published: April 2022

AbstractPhytomelatonin is a newly identified plant hormone, and its primary functions in plant growth and development remain relatively poorly appraised. Phytomelatonin is a master regulator of reactive oxygen species (ROS) signaling and acts as a darkness signal in circadian stomatal closure. Plants exhibit at least three interrelated patterns of interaction between phytomelatonin and ROS production. Exogenous melatonin can induce flavonoid biosynthesis, which might be required for maintenance of antioxidant capacity under stress, after harvest, and in leaf senescence conditions. However, several genetic studies have provided direct evidence that phytomelatonin plays a negative role in the biosynthesis of flavonoids under non-stress conditions. Phytomelatonin delays flowering time in both dicot and monocot plants, probably via its receptor PMTR1 and interactions with the gibberellin, strigolactone, and ROS signaling pathways. Furthermore, phytomelatonin signaling also functions in hypocotyl and shoot growth in skotomorphogenesis and ultraviolet B (UV-B) exposure; the G protein α-subunit (Arabidopsis GPA1 and rice RGA1) and constitutive photomorphogenic1 (COP1) are important signal components during this process. Taken together, these findings indicate that phytomelatonin acts as a darkness signal with important regulatory roles in circadian stomatal closure, flavonoid biosynthesis, flowering, and hypocotyl and shoot growth.
DeepLoc 2.0: multi-label subcellular localization prediction using protein language models
Authors: Thumuluri Vineet , Almagro Armenteros José Juan , Johansen Alexander Rosenberg , Nielsen Henrik , Winther Ole 
Published: April 2022

AbstractThe prediction of protein subcellular localization is of great relevance for proteomics research. Here, we propose an update to the popular tool DeepLoc with multi-localization prediction and improvements in both performance and interpretability. For training and validation, we curate eukaryotic and human multi-location protein datasets with stringent homology partitioning and enriched with sorting signal information compiled from the literature. We achieve state-of-the-art performance in DeepLoc 2.0 by using a pre-trained protein language model. It has the further advantage that it uses sequence input rather than relying on slower protein profiles. We provide two means of better interpretability: an attention output along the sequence and highly accurate prediction of nine different types of protein sorting signals. We find that the attention output correlates well with the position of sorting signals. The webserver is available at services.healthtech.dtu.dk/service.php?DeepLoc-2.0.
Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis
Authors: Michl-Holzinger Philipp , Obermeyer Simon , Markusch Hanna , Pfab Alexander , Ettner Andreas , Bruckmann Astrid , Babl Sabrina , Längst Gernot , Schwartz Uwe , Tvardovskiy Andrey , Jensen Ole N , Osakabe Akihisa , Berger Frédéric , Grasser Klaus D 
Published: April 2022

Abstract
The heterodimeric histone chaperone FACT, consisting of SSRP1 and SPT16, contributes to dynamic nucleosome rearrangements during various DNA-dependent processes including transcription. In search of post-translational modifications that may regulate the activity of FACT, SSRP1 and SPT16 were isolated from Arabidopsis cells and analysed by mass spectrometry. Four acetylated lysine residues could be mapped within the basic C-terminal region of SSRP1, while three phosphorylated serine/threonine residues were identified in the acidic C-terminal region of SPT16. Mutational analysis of the SSRP1 acetylation sites revealed only mild effects. However, phosphorylation of SPT16 that is catalysed by protein kinase CK2, modulates histone interactions. A non-phosphorylatable version of SPT16 displayed reduced histone binding and proved inactive in complementing the growth and developmental phenotypes of spt16 mutant plants. In plants expressing the non-phosphorylatable SPT16 version we detected at a subset of genes enrichment of histone H3 directly upstream of RNA polymerase II transcriptional start sites (TSSs) in a region that usually is nucleosome-depleted. This suggests that some genes require phosphorylation of the SPT16 acidic region for establishing the correct nucleosome occupancy at the TSS of active genes.
Microvascular remodeling and altered angiogenic signaling in human kidneys distal to occlusive atherosclerotic renal artery stenosis
Authors: Klomjit Nattawat , Zhu Xiang-Yang , Eirin Alfonso , Pawar Aditya S , Conley Sabena M , Puranik Amrutesh S , Ferguson Christopher M , Kim Seo Rin , Tang Hui , Jordan Kyra L , Saadiq Ishran M , Lerman Amir , Grande Joseph P , Textor Stephen C , Lerman Lilach O 
Published: April 2022

ABSTRACT

Background
Renal artery stenosis (RAS) is an important cause of chronic kidney disease and secondary hypertension. In animal models, renal ischemia leads to downregulation of growth factor expression and loss of intrarenal microcirculation. However, little is known about the sequelae of large-vessel occlusive disease on the microcirculation within human kidneys.

Method
This study included five patients who underwent nephrectomy due to renovascular occlusion and seven nonstenotic discarded donor kidneys (four deceased donors). Micro-computed tomography was performed to assess microvascular spatial densities and tortuosity, an index of microvascular immaturity. Renal protein expression, gene expression and histology were studied in vitro using immunoblotting, polymerase chain reaction and staining.

Results
RAS demonstrated a loss of medium-sized vessels (0.2–0.3 mm) compared with donor kidneys (P = 0.037) and increased microvascular tortuosity. RAS kidneys had greater protein expression of angiopoietin-1, hypoxia-inducible factor-1α and thrombospondin-1 but lower protein expression of vascular endothelial growth factor (VEGF) than donor kidneys. Renal fibrosis, loss of peritubular capillaries (PTCs) and pericyte detachment were greater in RAS, yet they had more newly formed PTCs than donor kidneys. Therefore, our study quantified significant microvascular remodeling in the poststenotic human kidney. RAS induced renal microvascular loss, vascular remodeling and fibrosis. Despite downregulated VEGF, stenotic kidneys upregulated compensatory angiogenic pathways related to angiopoietin-1.

Conclusions
These observations underscore the nature of human RAS as a microvascular disease distal to main vessel stenosis and support therapeutic strategies directly targeting the poststenotic kidney microcirculation in patients with RAS.
Religion and Risk of Suicide: A Cross-National Study of Cultural Differences
Authors: Iidaka Tetsuya 
Published: April 2022

Abstract
Preventing death from suicide remains a major issue in global mental health even though the suicide rate worldwide has been gradually decreasing over the last 15 years. The trend is decreasing, but the change is small; therefore, more effective sex- and culture-specific treatments for suicide prevention are needed. This chapter focuses on religion, which is a major factor in culture and belief and plays an important role in people’s lives and deaths, and reports the relationship between suicide and self-declared religion worldwide. The chapter discusses an analysis that used a cross-national approach in which suicide rates and religious composition were correlated across countries based on a large census dataset from 2015. There was a strong preventive effect of religion on suicide; however, the effect was weaker in religions originating from Eastern cultures than Western and Middle Eastern cultures. A weak preventive effect on suicide was observed mainly in women living in Eastern cultures. The chapter also briefly describes the rise and fall of the suicide rate in Japan, which paralleled the downturn and upturn of the economic condition of the nation. Some psychological characteristics of Japanese workers based on its culture are discussed.
Single-parent expression complementation contributes to phenotypic heterosis in maize hybrids
Authors: Baldauf Jutta A , Liu Meiling , Vedder Lucia , Yu Peng , Piepho Hans-Peter , Schoof Heiko , Nettleton Dan , Hochholdinger Frank 
Published: April 2022

Abstract
The dominance model of heterosis explains the superior performance of F1-hybrids via the complementation of deleterious alleles by beneficial alleles in many genes. Genes active in one parent but inactive in the second lead to single-parent expression (SPE) complementation in maize (Zea mays L.) hybrids. In this study, SPE complementation resulted in approximately 700 additionally active genes in different tissues of genetically diverse maize hybrids on average. We established that the number of SPE genes is significantly associated with mid-parent heterosis (MPH) for all surveyed phenotypic traits. In addition, we highlighted that maternally (SPE_B) and paternally (SPE_X) active SPE genes enriched in gene co-expression modules are highly correlated within each SPE type but separated between these two SPE types. While SPE_B-enriched co-expression modules are positively correlated with phenotypic traits, SPE_X-enriched modules displayed a negative correlation. Gene ontology term enrichment analyses indicated that SPE_B patterns are associated with growth and development, whereas SPE_X patterns are enriched in defense and stress response. In summary, these results link the degree of phenotypic MPH to the prevalence of gene expression complementation observed by SPE, supporting the notion that hybrids benefit from SPE complementation via its role in coordinating maize development in fluctuating environments.
Virtual reality in Metaverse for future mental health-helping profession: an alternative solution to the mental health challenges of the COVID-19 pandemic
Authors: Ifdil Ifdil , Situmorang Dominikus David Biondi , Firman Firman , Zola Nilma , Rangka Itsar Bolo , Fadli Rima Pratiwi 
Published: April 2022

AbstractCurrently, Metaverse has become a hot topic of conversation everywhere. Therefore, this can also be an accurate solution to the mental health challenges of the COVID-19 pandemic. Hopefully in the future, mental health workers can make the best use of it.
Chemtrails in the skies of Indonesia: are they conspiracies to cause prolonged COVID-19?
Authors: Situmorang Dominikus David Biondi , Ifdil Ifdil , Salim Rose Mini Agoes 
Published: April 2022

AbstractIn Indonesia, there is currently a hot discussion regarding chemtrails appearing in the skies in several cities. Many people attribute this to conspiracy theories, according to which these chemtrails cause the omicron-type of coronavirus disease 2019 (B.1.1.529). Through this paper, we hope that Indonesian citizens be able to think more positively and maintain their mental and physical health.
The impact of psoriasis on the clinical characteristics, disease burden and treatment patterns of peripheral spondyloarthritis
Authors: Izci Duran Tugba , Torgutalp Murat , Rios Rodriguez Valeria , Proft Fabian , López-Medina Clementina , Dougados Maxime , Poddubnyy Denis 
Published: April 2022

AbstractObjectivesTo evaluate the clinical characteristics, disease burden, and treatment patterns of peripheral spondyloarthritis (pSpA) patients with and without psoriasis using data from the ASAS-perSpA study.MethodsWe included 433 patients who had a diagnosis of pSpA according to the rheumatologist’s diagnosis from the ASAS-PerSpA study. The presence of a personal history of psoriasis was defined as the presence of signs of psoriasis at physical examination or the presence of psoriatic nail dystrophy, including onycholysis, pitting and hyperkeratosis, or a history of psoriasis diagnosed by a physician. Clinical characteristics, patient-reported outcomes and treatment pattern were compared between subgroups with and without psoriasis.ResultsA total of 83 patients (19.2%) had a personal history of psoriasis. Patients with psoriasis were older (48.4 vs 43.2 years) and had a longer diagnostic delay (7.4 vs 3.5 years), a higher frequency of dactylitis (36.1 vs 20.0%) and enthesitis (65.1 vs 55.4%) than patients without psoriasis. A longer diagnostic delay (odds ratio [OR] = 1.06 [95% CI 1.01, 1.11]), lower odds for HLA-B27 positivity (OR = 0.31 [95% CI 0.15, 0.65]) and higher odds for enthesitis (OR = 2.39 [95% CI 1.16, 4.93]) were associated with the presence of psoriasis in a multivariable regression analysis. While patient-reported outcomes were comparable between groups, a higher use of biologic DMARDs was observed in patients with vs without psoriasis.ConclusionThe presence of psoriasis has an impact on clinical characteristics of pSpA. pSpA patients without psoriasis were less frequently treated with biologic DMARDs despite similar disease burden as compared with patients with psoriasis.
Robots and protest: does increased protest among Chinese workers result in more automation?
Authors: Liu Larry , Zhang Han 
Published: April 2022

Abstract
The rising level of automation has increasingly attracted scholars' attention. On the other hand, there are many studies of the consequences of social movements, but relatively fewer studies focus on their economic consequences, and even fewer studies have examined their consequences on automation. This article bridges the gap between the two literatures by hypothesizing that a rising number of labor protests will lead to a higher level of automation. We argue that political economy factors influence the adoption of more automation. Protests anticipate higher wages and labor costs; contest for social power with employers and the state, and, in extreme cases, pose a public relations challenge to employers, which will likely push employers to replace human workers with robots. We empirically test the relationship by using two protest event datasets in China, the China Labor Bulletin and Collective Action from Social Media and robot data from the International Federation of Robotics. Statistical analysis shows that provinces and industries that have more protests also tend to concentrate more robots, and the results are robust to most specifications and placebo tests. The findings have implications for both understanding the mechanism explaining rising automation and the consequences of social protests.