bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk stratification and prognosis prediction based on inflammation‐related gene signature in lung squamous carcinoma
Authors: Zhai Wenyu , Chen Si , Duan Fangfang , Wang Junye , Zhao Zerui , Lin Yaobin , Rao Bingyu , Wang Yizhi , Zheng Lie , Long Hao 
Published: September 2022

AbstractBackgroundInflammation is known to have an intricate relationship with tumorigenesis and tumor progression while it is also closely related to tumor immune microenvironment. Whereas the role of inflammation‐related genes (IRGs) in lung squamous carcinoma (LUSC) is barely understood. Herein, we recognized IRGs associated with overall survival (OS), built an IRGs signature for risk stratification and explored the impact of IRGs on immune infiltration landscape of LUSC patients.MethodsThe RNA‐sequencing and clinicopathological data of LUSC patients were downloaded from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database, which were defined as training and validation cohorts. Cox regression and least absolute shrinkage and selection operator analyses were performed to build an IRG signature. CIBERSORT, microenvironment cell populations‐counter and tumor immune dysfunction and rejection (TIDE) algorithm were used to perform immune infiltration analysis.ResultsA two‐IRG signature consisting of KLF6 and SGMS2 was identified according to the training set, which could categorize patients into two different risk groups with distinct OS. Patients in the low‐risk group had more anti‐tumor immune cells infiltrated while patient with high‐risk had lower TIDE score and higher levels of immune checkpoint molecules expressed. The IRG signature was further identified as an independent prognostic factor of OS. Subsequently, a prognostic nomogram including IRG signature, age, and cancer stage was constructed for predicting individualized OS, whose concordance index values were 0.610 (95% CI: 0.568–0.651) in the training set and 0.652 (95% CI: 0.580–0.724) in validation set. Time‐dependent receiver operator characteristic curves revealed that the nomogram had higher prediction accuracy compared with the traditional tumor stage alone.ConclusionThe IRG signature was a predictor for patients with LUSC and might serve as a potential indicator of the efficacy of immunotherapy. The nomogram based on the IRG signature showed a relatively good predictive performance in survival.
Metagenomic analysis of the fecal microbiome in colorectal cancer patients compared to healthy controls as a function of age
Authors: Kharofa Jordan , Apewokin Senu , Alenghat Theresa , Ollberding Nicholas J. 
Published: September 2022

AbstractBackground and AimsColorectal cancer (CRC) incidence is increasing in young patients without a clear etiology. Emerging data have implicated the fecal microbiome in CRC carcinogenesis. However, its impact on young onset CRC is poorly defined.MethodsWe performed a meta‐analysis of fecal metagenomics sequencing data from n = 692 patients with CRC and n = 602 healthy controls from eleven studies to evaluate features of the fecal metagenome associated with CRC. We hypothesized that known carcinogenic virulence factors (colibactin, fadA) and species abundance may be differentially enriched in young CRC patients relative to older CRC patients and controls.ResultsSummary odds ratios (OR) for CRC were increased with the presence of colibactin (OR 1.92 95% CI 1.08–3.38), fadA (OR 4.57 95% CI 1.63–12.85), and F. nucleatum (OR 6.93 95% CI 3.01–15.96) in meta‐analysis models adjusted for age, gender, and body mass index. The OR for CRC for the presence of E.coli was 2.02 (0.92–4.45). An increase in the prevalence of Fusobacterium nucleatum (OR = 1.40 [1.18; 1.65]) and Escherichia coli (OR = 1.14 [1.02; 1.28]) per 10‐year increase in age was observed in models including samples from both CRC and healthy controls. Species relative abundance was differentially enriched in young CRC patients for five species‐Intestinimonas butyriciproducens, Holdemania filiformis, Firimicutues bacterium CAG 83, Bilophilia wadsworthia, and Alistipes putredinis.ConclusionIn this study, we observed strong associations with CRC status for colibactin, fadA, and Fusobacterium nucleatum with CRC relative to controls. In addition, we identified several microbial species differentially enriched in young colorectal cancer patients. Studies targeting the young CRC patients are warranted to elucidate underlying preclinical mechanisms.
Alveolar ridge augmentation for implant placement in a growing patient
Authors: Meghil Mohamed M. , Lowry Scott , Lyons Collins , Ghaly Mira 
Published: September 2022

AbstractBackgroundPartial edentulism in growing children due to aplasia or trauma poses a difficult situation to manage. We present a case of horizontal ridge augmentation in a growing patient who had trauma in childhood when it was too early to place implants.Methods and ResultsThis patient had a history of trauma, at age 13, that resulted in mandibular fracture and loss of teeth #23–27. The definitive restorative treatment plan was postponed due to the patient's continued growth. At age 18, horizontal bone augmentation was performed in a severely resorbed anterior mandible. After 7 months of healing, 7–8 mm ridge augmentation was achieved, and three implants were placed. Soft tissue augmentation by free gingival graft was performed at implant second stage surgery 4 months later.ConclusionsWhen considering the timing of implant placement in adolescents, the clinician walks a fine line between waiting as long as possible to place the implants and racing against continued resorption of the edentulous alveolar ridge. 70/30 mineralized/demineralized cortical bone allograft and injectable platelet‐rich fibrin mix combined with tenting screws and resorbable membranes are useful measures for horizontal ridge augmentation in growing patients.Key pointsWhy is this case new information?

There are insufficient data available when considering implant treatment in younger patients. The present case was managed with a variation of the sausage technique described by Urban. The use of allograft, I‐PRF, and tenting screws replaced the use of autogenous bone and resulted in exceptional results.
What are the keys to the successful management of this case?

Delaying treatment until after the critical growth period has passed. Adequate flap release, tension‐free primary flap closure, and space maintenance through the use of tenting screws and tacking the membranes using tacking pins provided support for the grafted site.
What are the primary limitations to success in this case?

The continued growth may cause infra occlusion of the implant‐supported bridge.
Selected Aspects of InvasiveSolidago canadensiswith an Emphasis on Its Allelopathic Abilities: A Review
Authors: Zhu Xunzhi , Li Weijie , Shao Hua , Tang Shijie 
Published: September 2022

AbstractSolidago canadensisL., native to North America, is now an invasive plant worldwide. Its abundant seeds, rapid vegetative reproduction ability, and allelopathy to other plants are the main reasons for its successful invasion. It has negative impacts on the ecological environment of the invaded area and causes a reduction in local biodiversity and economic losses of agriculture and stock farming. Each part of the plant contains a variety of allelochemicals (terpenoids, phenolics, and flavonoids), including a large number of essential oil components. These allelochemicals can be released in various ways to inhibit the growth of adjacent plants and promote their invasion; they can also affect soil properties and soil microorganisms. This article summarizes the allelopathic effects ofS. canadensison other plant species and the interaction mechanism between it and the ecosystem.
The relationship between self‐forgiveness and psychological wellbeing in prison inmates: The mediating role of mindfulness
Authors: Paleari Giorgia F. , Danioni Francesca , Pelucchi Sara , Lombrano Maria Rita , Lumera Daniel , Regalia Camillo 
Published: September 2022

AbstractBackgroundPrevious research with general population samples has consistently shown that forgiveness and mindfulness facilitate coping with distressing experiences and significantly promote mental health. No study, however, has examined their unique contribution to prisoners' psychological wellbeing nor has considered the different forms of self‐forgiveness among prisoners.AimsOur aim was to investigate the role of mindfulness in mediating any association between prisoners' self‐forgiveness and psychological wellbeing and to test whether any such links are moderated by years spent in prison. In this study self‐forgiveness was conceptualised as a multidimensional construct, including presence of genuine self‐forgiveness, absence of pseudo self‐forgiveness and/or absence of self‐punitiveness.MethodsParticipants were recruited from a prison in Northern Italy. Consenting men were asked to complete an anonymous self‐report questionnaire with only a researcher present.Results104 male prisoners (mean age 46.63 years, SD 11.38) took part. Findings were that self‐punitiveness was inversely related to well‐being, with mindfulness mediating this relationship, this while controlling for the other dimensions of self‐forgiveness and the perceived severity of the crime committed. Contrary to expectation, we found no direct relationship between genuine self‐forgiveness and well‐being, but the moderated mediation models showed that genuine self‐forgiveness was positively associated with mindfulness and, through this, had an indirect association with wellbeing, significant only for prisoners who had already spent several years in prison.ConclusionsOur findings confirm that self‐forgiveness is a complex construct, worthy of further investigation among offenders. They suggest that forgiveness interventions for prisoners should include modules aimed at primarily reducing self‐punitive attitudes. Promotion of genuine self‐forgiveness should be tried only with awareness that this is likely to take a very long time. In such circumstances, interventions may promote energy to be invested in mindful processes with a consequent improvement in psychological wellbeing.
Intractable low back pain during acute exacerbation of systemic lupus erythematosus
Authors: Boulas Konstantinos A. , Nathanailidou Maria , Sitaridis Konstantinos , Filippidis Isaac , Tsiariglis Ioannis , Hatzigeorgiadis Anestis 
Published: September 2022

AbstractDiagnosis of acute low back emergencies during a systemic lupus erythematosus flare necessitates high clinical suspicion and early CT.
Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
Authors: Wang Mawson , Samra Spinder , Chou Shaun , Howle Julie , Gild Matti L. , Girgis Christian Meena 
Published: September 2022

AbstractThyroid cancer is the most common endocrine cancer, with papillary thyroid carcinoma (PTC) accounting for the majority of these cases. Cerebellar metastasis is rarely the presenting feature and confers poor prognosis. Genetic mutations in this setting are most commonly TERTp, in contrast to BRAFV600E in the majority of PTC. We report the case of an 82 year‐old male who presented with a symptomatic right cerebellar lesion and underwent surgical resection to demonstrate metastatic PTC. Extensive workup with computed tomography, neck ultrasound and FDG‐PET was suggestive of a left thyroid primary lesion, with FNA confirming PTC. However, total thyroidectomy demonstrated incidental microMTC (medullary thyroid microcarcinoma, defined as tumour <10mm) without any evidence of PTC, whereas the left level VI neck dissection demonstrated a 30mm nodule of PTC without identifiable normal thyroid or lymph node tissue.
Intraabdominal guidewire‐related perforation of the esophagus: An uncommon complication of esophageal bougienage treated by intraprocedural clip closure
Authors: Zimmer Vincent 
Published: September 2022

AbstractEsophageal perforation is an uncommon, though typical complication of esophageal bougienage. However, guidewire‐related transmural injury distant from the stricture has only rarely been reported. Post‐procedural endoscopy is critical to appreciate perforation and proved instrumental in a unique clinical case with immediate clip closure.
Cutaneous involvement in relapsed multiple myeloma
Authors: Salle Valéry , Attencourt Christophe , Chevalier Marion , Semeria Lucile , Boulu Xavier , Karam Jean‐Denis , Smail Amar , Schmidt Jean , Duhaut Pierre , Dernoncourt Amandine 
Published: September 2022

AbstractCutaneous involvement in multiple myeloma with extramedullary disease is rare. We report the case of a refractory multiple myeloma patient who developed a cutaneous lesion. Histopathology revealed dermal immature plasma cell infiltrate with a lack of CD138 expression. This cutaneous location was associated with an aggressive clinical course and short survival.
Nickel Nanoparticles Immobilized on Pristine Halloysite: An Outstanding Catalyst for Hydrogenation Processes
Authors: Pérez Alonso Alejandro , Mauriés Steven , Ledeuil Jean‐Bernard , Madec Lénaïc , Pham Minh Doan , Pla Daniel , Gómez Montserrat 
Published: September 2022

AbstractNickel nanoparticles (NiNPs) immobilized on halloysite‐based supports were straightforwardly synthesized and fully characterized by different techniques with the purpose of evaluating the catalytic performance of these as‐prepared composite materials as catalysts in hydrogenation reactions. Thus, halloysite bearing amino (HAL‐NH2) and ammonium (HAL‐NEt3) groups led to less active catalytic materials in comparison with unfunctionalized halloysite supports, probably due to relative strong metal‐support interactions with amino and tetraalkylammonium functions, consequently hindering the interaction of unsaturated substrates at the surface of the catalytic material. Despite NiNPs supported on pristine halloysite provided merely agglomerates, NiNPs stabilized by quinidine on unfunctionalized halloysite (NiC) proved to be a highly effective and versatile catalyst operating at relative low temperature (25–100 °C) and metal loading (1–20 mol %Ni), very well‐adapted to reduce a large range of functions (alkenes, alkynes, ketones, aldehydes, nitro…). Moreover, NiC was able to selectively reduce substrates from biomass to yield high value‐added products, such as squalane, saturated fatty acids, furfuryl alcohol and γ‐valerolactone.
Revealing the Effect of Surface Composition on Multiwalled Carbon Nanotubes Supported Pt‐Fe Alloy Electrocatalysts for Methanol Oxidation Performance
Authors: Wang Zhengcheng , Zhou Shangyan , Liao Wei , Zhou Qian , Chen Meida , Long Jin , Wang Qingmei 
Published: September 2022

AbstractThe designs of efficient and inexpensive Pt‐based catalysts for methanol oxidation reaction (MOR) are essential to boost the commercialization of direct methanol fuel cells. Here, the highly catalytic performance PtFe alloys supported on multiwalled carbon nanotubes (MWCNTs) decorating nitrogen‐doped carbon (NC) have been successfully prepared via co‐engineering of the surface composition and electronic structure. The Pt1Fe3@NC/MWCNTs catalyst with moderate Fe3+ feeding content (0.86 mA/mgPt) exhibits 2.26‐fold enhancement in MOR mass activity compared to pristine Pt/C catalyst (0.38 mA/mgPt). Furthermore, the CO oxidation initial potential of Pt1Fe3@NC/MWCNTs catalyst is lower relative to Pt/C catalyst (0.71 V and 0.80 V). Benefited from the optimal surface compositions, the anti‐corrosion ability of MWCNT, strong electron interaction between PtFe alloys and MWCNTs and the N‐doped carbon (NC) layer, the Pt1Fe3@NC/MWCNTs catalyst presents an improved MOR performance and anti‐CO poisoning ability. This study would open up new perspective for designing efficient electrocatalysts for the DMFCs field.
Differential Tunneling‐Driven and Vibrationally‐Induced Reactivity in Isomeric Benzazirines
Authors: Nunes Cláudio M. , Doddipatla Srinivas , Loureiro Gonçalo F. , Roque José P. L. , Pereira Nelson A. M. , Pinho e Melo Teresa M. V. D. , Fausto Rui 
Published: September 2022

AbstractQuantum mechanical tunneling of heavy‐atoms and vibrational excitation chemistry are unconventional and scarcely explored types of reactivity. Once fully understood, they might bring new avenues to conduct chemical transformations, providing access to a new world of molecules or ways of exquisite reaction control. In this context, we present here the discovery of two isomeric benzazirines exhibiting differential tunneling‐driven and vibrationally‐induced reactivity, which constitute exceptional results for probing into the nature of these phenomena. The isomeric 6‐fluoro‐ and 2‐fluoro‐4‐hydroxy‐2H‐benzazirines (3‐a and 3′‐s) were generated in cryogenic krypton matrices by visible‐light irradiation of the corresponding triplet nitrene 32‐a, which was produced by UV‐light irradiation of its azide precursor. The 3′‐s was found to be stable under matrix dark conditions, whereas 3‐a spontaneously rearranges (τ1/2 ∼64 h at 10 and 20 K) by heavy‐atom tunneling to 32‐a. Near‐IR‐light irradiation at the first OH stretching overtone frequencies (remote vibrational antenna) of the benzazirines induces the 3′‐s ring‐expansion reaction to a seven‐member cyclic ketenimine, but the 3‐a undergoes 2H‐azirine ring‐opening reaction to triplet nitrene 32‐a. Computations demonstrate that 3‐a and 3′‐s have distinct reaction energy profiles, which explain the different experimental results. The spectroscopic direct measurement of the tunneling of 3‐a to 32‐a constitutes a unique example of an observation of a species reacting only by nitrogen tunneling. Moreover, the vibrationally‐induced sole activation of the most favorable bond‐breaking/bond‐forming pathway available for 3‐a and 3′‐s provides pioneer results regarding the selective nature of such processes.
Sterically and Electronically Flexible Pyridylidene Amine Dinitrogen Ligands at Palladium: Hemilabile cis/trans Coordination and Application in Dehydrogenation Catalysis
Authors: Lentz Nicolas , Streit Yanik , Knörr Pascal , Albrecht Martin 
Published: September 2022

AbstractLigand design is crucial for the development of new catalysts and materials with new properties. Herein, the synthesis and unique hemilabile coordination properties of new bis‐pyridylidene amine (bis‐PYE) ligands to palladium, and preliminary catalytic activity of these complexes in formic acid dehydrogenation are described. The synthetic pathway to form cationic complexes [Pd(bis‐PYE)Cl(L)]X with a cis‐coordinated N,N‐bidentate bis‐PYE ligand is flexible and provides access to a diversity of PdII complexes with different ancillary ligands (L=pyridine, DMAP, PPh3, Cl, P(OMe)3). The 1H NMR chemical shift of the trans‐positioned PYE N−CH3 unit is identified as a convenient and diagnostic handle to probe the donor properties of these ancillary ligands and demonstrates the electronic flexibility of the PYE ligand sites. In the presence of a base, the originally cis‐coordinated bis‐PYE ligand adopts a N,N,N‐tridentate coordination mode with the two PYE units in mutual trans position. This cis–trans isomerization is reverted in presence of an acid, demonstrating a unique structural and steric flexibility of the bis‐PYE ligand at palladium in addition to its electronic adaptability. The palladium complexes are active in formic acid dehydrogenation to H2 and CO2. The catalytic performance is directly dependent on the ligand bonding mode, the nature of the ancillary ligand, the counteranion, and additives. The most active system features a bidentate bis‐PYE ligand, PPh3 as ancillary ligand and accomplishes turnover frequencies up to 525 h−1 in the first hour and turnover numbers of nearly 1000, which is the highest activity reported for palladium‐based catalysts to date.
Antifungal Graphene‐based Absorbers as Advanced Materials for Preventive Conservation of Cultural Objects
Authors: Gorgolis George , Messina Elena , Kotsidi Maria , Staccioli Maria Paola , Lesaria Nhuch Elsa , Di Carlo Gabriella , Schrekker Henri Stephan , Paterakis George , Koutroumanis Nikos , Galiotis Costas 
Published: September 2022

AbstractThe development of innovative materials for preventive conservation of cultural objects against known threats, such as fungi and volatile organic compounds (VOCs) that often exist in museums and galleries, is still challenging. In this work, graphene‐based aerogels with an ionic liquid (IL) additive were prepared, and their anti‐fungal and VOCs absorption properties were investigated. Several IL contents were evaluated and the graphene aerogel containing 10 wt.% IL was found to have the best anti‐fungal activity, preventing the aerogel contamination with Aspergillus niger. When exposed to a VOC saturated micro‐environment, this aerogel was highly suitable for the absorption of acetaldehyde, formic acid, acetic acid, and formaldehyde. This combined anti‐fungal and VOC absorption properties are prerequisites for bringing preventive conservation to a higher level.
An Extremal Problem Arising in the Dynamics of Two‐Phase Materials That Directly Reveals Information about the Internal Geometry
Authors: Mattei Ornella , Milton Graeme W. , Putinar Mihai 
Published: September 2022

AbstractIn two‐phase materials, each phase having a non‐local response in time, it has been found that for some driving fields the response somehow untangles at specific times, and allows one to directly infer useful information about the geometry of the material, such as the volume fractions of the phases. Motivated by this, and to obtain an algorithm for designing appropriate driving fields, we find approximate, measure independent, linear relations between the values that Markov functions take at a given set of possibly complex points, not belonging to the interval [‐1,1] where the measure is supported. The problem is reduced to simply one of polynomial approximation of a given function on the interval [‐1,1] and, to simplify the analysis, Chebyshev approximation is used. This allows one to obtain explicit estimates of the error of the approximation, in terms of the number of points and the minimum distance of the points to the interval [‐1,1]. Assuming this minimum distance is bounded below by a number greater than 1/2, the error converges exponentially to zero as the number of points is increased. Approximate linear relations are also obtained that incorporate a set of moments of the measure. In the context of the motivating problem, the analysis also yields bounds on the response at any particular time for any driving field, and allows one to estimate the response at a given frequency using an appropriately designed driving field that effectively is turned on only for a fixed interval of time. The approximation extends directly to Markov‐type functions with a positive semidefinite operator valued measure, and this has applications to determining the shape of an inclusion in a body from boundary flux measurements at a specific time, when the time‐dependent boundary potentials are suitably tailored. © 2022 Wiley Periodicals, Inc.