bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Victimized to Victorious
Authors: Neuman Gdalit 
Published: April 2022

Abstract
The late Yehudit Arnon’s contributions to the world of dance preceded her tenure as Founding Artistic Director of Israel’s Kibbutz Contemporary Dance Company. In the immediate postwar period and in the framework of the Hashomer Hatzair Zionist youth movement, she created Zionist dance works which embodied the spirit of the day and which, at their core, expressed revolutionary ideas about gender and the Jewish body. This chapter examines two such dances and their impact on the identity formation of the Hungarian child Holocaust survivors who performed them. Utilizing extensive archival research, oral history interviews, and reconstruction methodologies, the chapter argues that Arnon utilized her platform of performance to promote the potential of these youths while they rapidly transitioned from their diasporic to Land of Israeli identities.
Feminism and #MeTooThe Power of the Collective
Authors: Green Tristin K. 
Published: April 2022

Abstract
#MeToo as a significant feminist movement calls us to consider what it—and the responses to it—reveal about challenges for feminism. In considering the strength and potential of this collective movement, we can draw lessons from contemporary commentary and from history, including the effort to combat sexual harassment through employment discrimination law. #MeToo may turn out to be the most powerful feminist movement of the twenty-first century. It brings to the forefront the depth and breadth of sexual abuse and harassment in our society and seeks meaningful structural change. It will only achieve that change, however, if its supporters can resist efforts to individualize what are at bottom collective stories and if they can respond adequately to competing collective counter-narratives.
Occulti Manifestatio: the Journey to God in Dionysius and Eriugena
Authors: Carabine Deirdre 
Published: April 2022

Abstract
This essay examines creation in Dionysius and Eriugena. Building on the Neoplatonic thematic of procession and return, it demonstrates that both thinkers held radical theological views on creation as the manifestation of the transcendent God. Pointing up the ontological significance of the apophatic and kataphatic theologies, Eriugena builds on the apophaticism of Dionysius to explain how God, through theophany, both makes all things and is made in all things. He further argues that creation ex nihilo is creation ex deo, but is resolute in his assertion that creation does not reveal God; rather, it conceals God. In the outward journey of unity into multiplicity God becomes not-God. Through the process of ex-stasis God goes out from God into the appearances of God, and ultimately calls all things back to God in a love-fuelled ecstasy. In this way the process of alterity, of God becoming not-God, is simultaneous revelation and concealment.
Origen, Celsus, and the Philosophers
Authors: Edwards Mark 
Published: April 2022

Abstract
This chapter investigates Origen’s knowledge of and skill in the polemical deployment of rhetoric in Contra Celsum. A new portrait of Origen as an apologist emerges as the author sketches a passable performance by a philosopher of the genre of rhetorical invective. In this chapter, the author shows how Origen’s mastery of the entire philosophical tradition, insider knowledge of its disputes, and the clever satire with which he outmanoeuvres Celsus redeem his reputation as an apologist and enhance his reputation as a scholar conversant with the entire philosophical tradition.
The Hermeneutical Foundations of Origen’s Soteriology
Authors: Niculescu Mihai Vlad 
Published: April 2022

Abstract
For the author of this chapter, the performative aspects of the language of exegesis, rather than doctrinal formulations reveal the dynamism of Origen’s system. Origen’s soteriology functions only through the performance of a complex exegetical process situated in a liturgical matrix. In exegetical preaching the interpreter of Scripture mediates an incarnation or presence of the Logos and the addressee is placed under the agency of the interpreted scriptural text with the power to transform. The transformative interpretation is coded for a progression of learning and insight for mixed communities (the simpliciores, the catechumens, the more advanced, and the spiritually mature). In this light, hermeneutically enacted salvation appears not only as a transformative comprehension of biblical doctrine, but also as a pertinent response to the Bible’s agency.
Origen’s Christology in the Context of the Second and Third Centuries
Authors: Martens Peter W. 
Published: April 2022

Abstract
This chapter grapples with the problem that the theological terms used to interpret Origen’s Christology and eschatology map a later set of terms and relations crafted in a different intellectual milieu. Origen’s Christology preceded the Chalcedonian binary of heresy and orthodoxy; ‘Christology’ did not become a theological term until the seventeenth century. The term ‘eschatology’ originated in the Scholastic period and ‘apocalyptic’ in the early twentieth century. To expand the scope of what Origen would have considered Christology, the author of this chapter introduces the notion of a biography of Christ that begins with protology, moves through Incarnation and the ministry of Jesus, and ends with eschatology. He then tracks Origen’s titles across the long arc between protology and eschatology, thus using Origen’s own categories to map a biography of Christ.
Health Literacy in Plastic Surgery: A Scoping Review
Authors: Tiourin Ekaterina , Barton Natalie , Janis Jeffrey E. 
Published: April 2022

Background:
Health literacy of plastic surgery patients may affect surgical decision-making and perioperative outcomes. In addition to consulting a plastic surgeon, patients often refer to online-based resources to learn about surgical options. The aim of this scoping review was to identify evidence detailing the state of health literacy of plastic surgery patients and available resources to highlight areas of improvement for clinical practice and future research.

Methods:
Utilizing PubMed and Web of Science databases, 46 eligible studies that analyzed health literacy in plastic surgery patients and readability of plastic surgery resources were included. Extracted characteristics from eligible studies included study size, type of analysis, findings, and conclusions.

Results:
Regardless of plastic surgery procedure or subspecialty, resources presenting plastic surgery information to patients exceeded the American Medical Association and National Institutes of Health recommended sixth- to eighth-grade reading level. Plastic surgery patients demonstrated greater knowledge of preoperative indications and surgical benefits compared with postoperative outcomes and surgical risks.

Conclusions:
Most health literacy research in plastic surgery focuses on readability of written internet-based resources as opposed to direct assessment of health literacy in plastic surgery patients. Plastic surgery resources exceed the recommended mean reading grade level. Dedicated efforts to recognize and accommodate a patient’s level of health literacy in plastic surgery should be considered.
Nurse practitioners in home-based prepalliative care demonstrate an innovative, value-based approach to end-of-life care planning
Authors: Coppa Denise , Winchester Suzy Barcelos , Maestri Xristin , Roberts Mary B. 
Published: April 2022

ABSTRACT

Background:
Nurse practitioners (NPs) demonstrate value-based, home-based primary health care (HBPC) to home-bound patients with high disease burden at reduced cost.

Purpose:
The research questions were as follows: (a) Does patient-centered, prepalliative care delivered by HBPC NPs decrease number of hospitalizations and emergency department (ED) visits and increase patient satisfaction? and (b) What are the criteria for patients to receive end-of-life (EOL) discussions by NPs?

Methodology:
This was a quasi-experimental, retrospective two-group design with a convenience sample of 233 HBPC patients from an academic clinical partnership compared with 234 clinic patients matched on age and Charlson Comorbidity Index (CCI) score over 4 years. Measures included signed advanced directives (ADRs), medical orders of life-sustaining treatment (MOLST) forms, number and length of home visits, hospitalizations, and ED visits after diagnosis. Chi-square analyses and general linear models using a Poisson distribution were conducted.

Results:
Home-based primary health care patients had higher disease burden, statistically higher CCI scores, and signed ADR and MOLST agreements more often than clinic patients with significantly fewer hospitalizations and ED visits, and longer visits with providers.

Conclusions:
Patients receiving HBPC for prepalliative, EOL illness benefit from more time to discuss the difficult factors surrounding access to care for those with life-threatening illnesses.

Implications:
Recipients of prepalliative HBPC by NPs could require fewer provider visits, hospitalizations and ED visits, patient satisfaction, and a potential decrease in health care spending at EOL.
Qualitative and quantitative methods in post-chemoradiation PET for head and neck cancer
Authors: Oldan Jorge D. , Beaty Brian M. , Jewells Valerie L. , Muhleman Mitchel A. , Benefield Thad , Chera Bhishamjit 
Published: April 2022

Objective
The aim of this study was to determine whether quantitative methods could aid in the evaluation of post-treatment head and neck scans, particularly taking human papillomavirus status into account.

Methods
Clinical readings of positron emission tomography/computed tomography scans as well as standardized uptake value (SUV)max (and other metrics) of nodes visible on PET conducted on a total of 172 patients with head and neck squamous cell cancer were examined. Locoregional recurrence at 2 years was assessed. In total 88 of these patients had close enough follow-up to determine whether individual nodes were positive or negative, and 233 nodes on these patients were compared to surgical pathology notes or follow-up (if no path was available).

Results
General negative predictive value (NPV) of complete response was 93% and an equivocal response was 89%; focusing on nodal recurrence, NPV was found to be 97% and positive predictive value (PPV) 46% if equivocal reads were treated as negative and NPV 98% and PPV 16% if equivocal reads were treated as positive. Using SUVmax of the hottest node with a cutoff of 3.4 gave NPV 97% and PPV 26%; a direct re-read (using 2 observers) gave NPV 98% and PPV 32% if equivocal reads were treated as negative, and NPV 99% and PPV 18% if equivocal reads were treated as positive. Using other first-order radiomics data such as SD and skewness did not improve this.

Conclusions
Quantitative data such as SUVmax does not show additional value over qualitative evaluation of response to chemoradiation in head and neck tumors.
When Blind Pathologists Lead Mute Clinicians: Autopsy of a Misdiagnosis Involving a Metastatic Lung Adenocarcinoma to the Breast Mimicking Primary Invasive Ductal Carcinoma
Authors: Gama Alcino , Novo Jorge Eduardo 
Published: April 2022

Abstract
Metastatic cancers to the breast are rare and can be diagnostically challenging. We present the case of a 59-year-old woman, previously diagnosed with lung adenocarcinoma, who developed breast masses. Her medical history was not known to the pathologist, and the case was misdiagnosed as invasive ductal carcinoma of the breast. Following communication with the clinical team, ancillary tests were performed, and the report was amended to metastatic lung adenocarcinoma to the breast, highlighting the importance of specimen transfer of care and communication of key clinical data.
Immune Correlates Analysis of a Single Ad26.COV2.S Dose in the ENSEMBLE COVID-19 Vaccine Efficacy Clinical Trial
Authors: Fong Youyi , McDermott Adrian B. , Benkeser David , Roels Sanne , Stieh Daniel J. , Vandebosch An , Gars Mathieu Le , Van Roey Griet A. , Houchens Christopher R. , Martins Karen , Jayashankar Lakshmi , Castellino Flora , Amoa-Awua Obrimpong , Basappa Manjula , Flach Britta , Lin Bob C. , Moore Christopher , Naisan Mursal , Naqvi Muhammed , Narpala Sandeep , O’Connell Sarah , Mueller Allen , Serebryannyy Leo , Castro Mike , Wang Jennifer , Petropoulos Christos J. , Luedtke Alex , Hyrien Ollivier , Lu Yiwen , Yu Chenchen , Borate Bhavesh , van der Laan Lars W. P. , Hejazi Nima S. , Kenny Avi , Carone Marco , Wolfe Daniel N. , Sadoff Jerald , Gray Glenda E. , Grinsztejn Beatriz , Goepfert Paul A. , Little Susan J. , Paiva de Sousa Leonardo , Maboa Rebone , Randhawa April K. , Andrasik Michele P. , Hendriks Jenny , Truyers Carla , Struyf Frank , Schuitemaker Hanneke , Douoguih Macaya , Kublin James G. , Corey Lawrence , Neuzil Kathleen M. , Carpp Lindsay N. , Follmann Dean , Gilbert Peter B. , Koup Richard A. , Donis Ruben O. ,   the Janssen Team,   the Coronavirus Vaccine Prevention Network (CoVPN)/ENSEMBLE Team,   the United States Government (USG)/CoVPN Biostatistics Team
Published: April 2022

AbstractAnti-spike IgG binding antibody, anti-receptor binding domain IgG antibody, and pseudovirus neutralizing antibody measurements four weeks post-vaccination were assessed as correlates of risk of moderate to severe-critical COVID-19 outcomes through 83 days post-vaccination and as correlates of protection following a single dose of Ad26.COV2.S COVID-19 vaccine in the placebo-controlled phase of ENSEMBLE, an international, randomized efficacy trial. Each marker had evidence as a correlate of risk and of protection, with strongest evidence for 50% inhibitory dilution (ID50) neutralizing antibody titer. The outcome hazard ratio was 0.49 (95% confidence interval 0.29, 0.81; p=0.006) per 10-fold increase in ID50; vaccine efficacy was 60% (43, 72%) at nonquantifiable ID50 (< 2.7 IU50/ml) and rose to 89% (78, 96%) at ID50 = 96.3 IU50/ml. Comparison of the vaccine efficacy by ID50 titer curves for ENSEMBLE-US, the COVE trial of the mRNA-1273 vaccine, and the COV002-UK trial of the AZD1222 vaccine supported consistency of the ID50 titer correlate of protection across trials and vaccine types.
XGBoost, a novel explainable AI technique, in the prediction of myocardial infarction, a UK Biobank cohort study
Authors: Moore Alexander , Bell Max 
Published: April 2022

AbstractBackground and objectiveMyocardial infarction is common and associated with high morbidity and mortality. This study assessed if “Explainable AI” in the form of extreme gradient boosting (XGBoost) could outperform traditional logistic regression in predicting myocardial infarction (MI) in a large cohort.MethodsWe compared two machine learning methods, XGBoost and logistic regression in predicting risk of MI. The UK Biobank is a population-based prospective cohort including 502 506 volunteers with active consent, aged 40–69 years at recruitment from 2006 to 2010. These subjects were followed until end of 2019 and the primary outcome was myocardial infarction.ResultsBoth models were trained using 90% of the cohort. The remaining 10% was used as a test set. Both models were equally precise, but the regression model classified more of the healthy class correctly. XGBoost was more accurate in identifying individuals who later suffered a myocardial infarction. Receiver operator characteristic (ROC) scores are class size invariant. In this metric XGBoost outperformed the logistic regression model, with ROC scores of 0.86 (accuracy 0.75; precision 0.99 and recall 0.75 for the healthy class; precision 0.07 and recall 0.81 for the MI-class) compared to 0.77 (accuracy 0.77; precision 0.99 and recall 0.77 for the healthy class; precision 0.07 and recall 0.78). Secondly, we demonstrate how SHAPley values can be used to visualize and interpret the predictions made by XGBoost models, both for the cohort test set and for individuals.ConclusionsThe XGBoost machine learning model shows very promising results in evaluating risk of MI in a large and diverse population. This model can be used, and visualized, both for individual assessments and in larger cohorts. The predictions made by the XGBoost models, points towards a future where “Explainable AI” may help to bridge the gap between medicine and data science.
The Brain Reacting to COVID-19: Analysis of the Cerebrospinal Fluid and Serum Proteome,Transcriptome and Inflammatory Proteins
Authors: Reinhold Dirk , Farztdinov Vadim , Yan Yan , Meisel Christian , Sadlowski Henrik , Kühn Joachim , Perschel Frank H. , Endres Mathias , Düzel Emrah , Vielhaber Stefan , Guttek Karina , Goihl Alexander , Venø Morten , Teegen Bianca , Stöcker Winfried , Stubbemann Paula , Kurth Florian , Sander Leif E. , Ralser Markus , Otto Carolin , Streit Simon , Jarius Sven , Ruprecht Klemens , Radbruch Helena , Kjems Jørgen , Mülleder Michael , Heppner Frank , Körtvelyessy Peter 
Published: April 2022

AbstractPatients with COVID-19 can have a variety of neurological symptoms, but the pathomechanism of CNS involvement in COVD-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 generally show no or only mild inflammation, more detailed data on inflammatory mediators in the CSF of patients with COVID-19 are scarce.Here, we used mass spectrometry to study the proteome, Enzym-linkend immunoassays, semiquantitative cytokine arrays, autoantibody screening, and RNA profiling to study the neuroinflammation. We study the inflammatory response in paired CSF and serum samples of patients with COVID-19 (n=38). Patients with herpes simplex virus encephalitis (HSVE, n=10) and patients with non-inflammatory, non-neurodegenerative neurological diseases (n=28) served as controls. Proteomics on single protein level and subsequent pathway analysis showed similar yet strongly attenuated inflammatory changes in the CSF of COVID-19 patients compared to HSVE patients. CSF/serum indices of interleukin-6, interleukin-16 and CXCL10 together point at an origin from these inflammatory proteins from outside the central nervous system. When stratifying COVID-19 patients into those with and without bacterial superinfection as indicated by elevated procalcitonin levels, inflammatory markers were significantly higher in those with concomitant bacterial superinfection. RNA sequencing in the CSF revealed 101 linear RNAs comprising messenger RNAs, micro RNAs and t-RNA fragments being significantly differentially expressed in COVID-19 than in HSVE or controls.Our findings may explain the absence of signs of intrathecal inflammation upon routine CSF testing despite the presence of SARS-CoV2 infection-associated neurological symptoms. The relevance of blood-derived mediators of inflammation in the CSF for neurological post-COVID-19 symptoms deserves further investigation.
Larger and more dentated hippocampal structure is associated with better memory in the oldest-old
Authors: Parpura Vuga , Caceres Hector S , Sims Sara A , Ver Hoef Lawrence , Ramaniharan Anandh K , Merritt Stacy , Rezaei Roxanne F , Bharadwaj Pradyumna K , Franchetti Mary Kate , Raichlen David A , Jessup Courtney J , Hishaw Alex G , Van Etten Emily J , Trouard Theodore P , Geldmacher David S , Wadley Virginia G , Alperin Noam , Porges Eric S , Woods Adam J , Cohen Ron A , Levin Bonnie E , Rundek Tatjana , Alexander Gene E , Visscher Kristina M 
Published: April 2022

AbstractEpisodic memory is widely recognized as a critically important aspect of cognition that is often impacted by cognitive and brain aging. Prior work has shown that episodic memory is related to the presence of teeth-like folds on the dentate gyrus, called dentation. We hypothesized that episodic memory performance relates to overall hippocampal structure (i.e., dentation and volume) in an oldest-old cohort. We used data from the McKnight Brain Aging Registry, which consisted of cognitively healthy 85+-year-old adults. We conducted a canonical correlation analysis on 111 participants between a set of episodic memory tests and a set of characterizations of hippocampal structure. The analysis yielded a strong canonical correlation between episodic memory and hippocampal structure (r = 0.491, p = <0.001). The results suggest there is a connection between hippocampal morphology and function in the oldest-old. Our findings suggest that dentation may play an important role in relation to the individual differences observed in episodic memory performance among the oldest old and that hippocampal structure supports healthy cognitive aging.HighlightsWe characterized hippocampal dentation in a healthy oldest-old sample.Hippocampal structure is related to episodic memory in healthy oldest-old adults.Memory functioning is related to both hippocampal volume and dentation.
DeepPerVar: a multimodal deep learning framework for functional interpretation of genetic variants in personal genome
Authors: Wang Ye , Chen Li 
Published: April 2022

AbstractMotivationUnderstanding the functional consequence of genetic variants, especially the noncoding ones, is important but particularly challenging. Genome-wide association studies or quantitative trait locus analyses may be subject to limited statistical power and linkage disequilibrium, and thus are less optimal to pinpoint the causal variants. Moreover, most existing machine learning approaches, which exploit the functional annotations to interpret and prioritize putative causal variants, cannot accommodate the heterogeneity of personal genetic variations and traits in a population study, targeting a specific disease.ResultsBy leveraging paired whole genome sequencing data and epigenetic functional assays in a population study, we propose a multi-modal deep learning framework to predict genome-wide quantitative epigenetic signals by considering both personal genetic variations and traits. The proposed approach can further evaluate the functional consequence of noncoding variants on an individual level by quantifying the allelic difference of predicted epigenetic signals. By applying the approach to the ROSMAP cohort studying Alzheimer’s disease (AD), we demonstrate that the proposed approach can accurately predict quantitative genome-wide epigenetic signals and in key genomic regions of AD causal genes, learn canonical motifs reported to regulate gene expression of AD causal genes, improve the partitioning heritability analysis, and prioritize putative causal variants in a GWAS risk locus. Finally, we release the proposed deep learning model as a stand-alone Python toolkit and a web server.Availabilityhttps://github.com/lichen-lab/DeepPerVar
Highly selective transgene expression through double-floxed inverted orientation system by using a unilateral spacer sequence
Authors: Matsushita Natsuki , Kato Shigeki , Nishizawa Kayo , Sugawara Masateru , Takeuchi Kosei , Miyasaka Yoshiki , Mashimo Tomoji , Kobayashi Kazuto 
Published: April 2022

SUMMARYThe double-floxed inverted orientation (DIO) system with adeno-associated viral (AAV) vector provides a beneficial approach to express transgenes in specific cell populations having Cre recombinase. A significant issue with this system is the protection against non-specific expression of transgenes in tissues after vector injection. We here show that Cre-independent recombination in AAV genome carrying the DIO sequence occurs during the production of viral vectors in packaging cells, which results in transgene expression in off-target populations. Introduction of a relatively longer nucleotide sequence between two recognition sites at the unilateral side of the transgene cassette, termed a unilateral spacer sequence (USS), is useful to suppress recombination during the vector production, leading to the protection of non-specific transgene expression with enhanced gene expression selectivity. Our DIO/USS system offers a powerful strategy for highly specific Cre-dependent transgene expression, aiming at various applications for structural and functional analyses of target cell populations.