bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family support role in hospital rapid response teams: a scoping review
Authors: Howlett Owen , Gleeson Rebecca , Jackson Lana , Rowe Elizabeth , Truscott Myf , Maggs Julie-Anne 
Published: March 2022

ABSTRACT

Objective:
The objective of this review was to identify and understand the primary research investigating the family support role in hospital rapid response teams.

Introduction:
Individual studies have described the benefits of providing emotional and psychosocial support to family members of a person receiving emergency medical care from a rapid response team in a hospital setting. To the authors’ knowledge, there are no studies that have identified and described these studies together.

Inclusion criteria:
All empirical qualitative and quantitative papers investigating a family support role delivered in a rapid response team in a hospital setting were included.

Methods:
This review followed a published a priori protocol. The databases searched were MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCO), Cochrane Library, and OpenGrey. The search strategy was not limited by publication date or by language. The title and abstract of all citations were reviewed by two authors independently to assess against the inclusion criteria. The full text of the studies meeting the inclusion criteria were retrieved and reviewed by two authors independently. Data from eligible studies were extracted by two authors separately using a predetermined data extraction form and summarized in tabular and narrative format.

Results:
After a full-text review of 110 studies, six studies met all inclusion criteria. The studies were set in four countries. All rapid response teams were set in hospital locations. Charted data demonstrated that the family support role had been investigated predominantly by qualitative study designs from the perspective of staff delivering the support. One study reported health outcomes of family members who received family support. In all studies, the family support role was part of a resuscitation rapid response team. Family support was provided at all stages of the resuscitation procedure. The family support role was not consistently defined, with the activities of the family support person reported differently between studies. Twenty-five varying support activities were described, such as attending to the family members’comfort needs, explaining the process of resuscitation, and providing guidance to the family member. In all studies, the family support role was available to support the family witnessing the resuscitation. The family support role was delivered by professionals from varying disciplines, including social workers, nurses, health care workers, and health care chaplains.

Conclusions:
Family support roles are varied and are carried out by health professionals of diverse backgrounds, highlighting the importance of considering the support and training needs of the person performing the role. Future research using evaluation methods is recommended to deepen the understanding about the family support role in hospital-based rapid response teams.
Nontubercular mycobacterial cough
Authors: Samitinjay Aditya , Ali Zulfikar , Biswas Rakesh 
Published: March 2022

SummaryHabitual cough suppression leading to non-tuberculous mycobacteria infections and bronchiectasis has been reported. We present a case of a 55-year-old woman with a chronic history of cough with mild expectoration and frequent lower respiratory tract infections, remitting with antibiotic therapy and other supportive measures. She also reported habitual cough suppression for several years. She was eventually diagnosed with Mycobacterium avium complex (MAC) positive right middle lobe bronchiectasis—Lady Windermere syndrome and obstructive sleep apnoea (OSA), causing disabling symptoms limiting her daily activities. We aim to highlight two key issues—diagnosing MAC infections in a tuberculosis endemic country, and OSA and its long-term clinical implications.
Differences in outcomes of patients with in-hospital versus out-of-hospital ST-elevation myocardial infarction: a registry analysis
Authors: Stehli Julia , Dagan Misha , Dinh Diem T , Lefkovits Jeffrey , Dick Ron , Oxley Stephanie , Brennan Angela L , Duffy Stephen J , Zaman Sarah 
Published: March 2022

ObjectivesPatients with ST-elevation myocardial infarction (STEMI) that occur while already in hospital (‘in-hospital STEMI’) face high mortality. However, data about this patient population are scarce. We sought to investigate differences in reperfusion and outcomes of in-hospital versus out-of-hospital STEMI.Design, Setting and ParticipantsConsecutive patients with STEMI all treated with percutaneous coronary intervention (PCI) across 30 centres were prospectively recruited into the Victorian Cardiac Outcomes Registry (2013–2018).Primary and secondary outcomesPatients with in-hospital STEMI were compared with patients with out-of-hospital STEMI with a primary endpoint of 30-day major adverse cardiovascular events (MACE). Secondary endpoints included ischaemic times, all-cause mortality and major bleeding.ResultsOf 7493 patients with PCI-treated STEMI, 494 (6.6%) occurred in-hospital. Patients with in-hospital STEMI were older (67.1 vs 62.4 years, p<0.001), more often women (32% vs 19.9%, p<0.001), with more comorbidities. Patients with in-hospital STEMI had higher 30-day MACE (20.4% vs 9.8%, p<0.001), mortality (12.1% vs 6.9%, p<0.001) and major bleeding (4.9% vs 2.3%, p<0.001), than patients with out-of-hospital STEMI. According to guideline criteria, patients with in-hospital STEMI achieved symptom-to-device times of ≤70 min and ≤90 min in 29% and 47%, respectively. Patients with out-of-hospital STEMI achieved door-to-device times of ≤90 min in 71%. Occurrence of STEMI while in hospital independently predicted higher MACE (adjusted OR 1.77, 95% CI 1.33 to 2.36, p<0.001) and 12-month mortality (adjusted OR 1.49, 95% CI 1.08 to 2.07, p<0.001).ConclusionsPatients with in-hospital STEMI experience delays to reperfusion with significantly higher MACE and mortality, compared with patients with out-of-hospital STEMI, after adjustment for confounders. Focused strategies are needed to improve recognition and outcomes in this high-risk and understudied population.
Use and usability of GP online services: a mixed-methods sequential study, before and during the COVID-19 pandemic, based on qualitative interviews, analysis of routine eConsult usage and feedback data, and assessment of GP websites in Devon and Cornwall, England
Authors: Jones Ray B , Tredinnick-Rowe John , Baines Rebecca , Maramba Inocencio Daniel Cortes , Chatterjee Arunangsu 
Published: March 2022

ObjectivesWe explored use and usability of general practitioner (GP) online services.SettingDevon and Cornwall, England.DesignMixed-methods sequential study based on qualitative interviews, analysis of routine eConsult usage and feedback data, and assessment of GP websites.MethodsFirst, we interviewed 32 staff and 18 patients from seven practices in June 2018. Second, we used routinely collected consultation meta-data and, third, patient feedback data for all practices using eConsult from June 2018 to March 2021. Lastly, we examined GP websites’ usability in January 2020 and September 2021.ResultsInterviews suggested practices infrequently involved patients in eConsult implementation. Some patients ‘gamed’ the system to achieve what they wanted. Usage data showed a major increase in eConsult resulting from COVID-19. Women used eConsult twice as much as men. Older had similar eConsult consultation rates to younger patients. Patient feedback forms were completed for fewer than 3% of consultations. Patients were mostly satisfied with eConsult but some had concerns about its length and repetitiveness, lack of continuity over time and between eConsult and medical records. We did not find clear evidence that patients’ suggested improvements were acted on. Finally, few GP websites met accessibility guidelines and may hinder access to online national services such as eConsult.ConclusionGiven that, face to face, older people consult more, usage data suggest that older people have reduced online access. That the female-to-male ratio of eConsult use use was even greater than ‘traditional’ face-to-face ratio was unexpected and needs further research. Although eConsult collects and uses routine patient feedback to improve the system, more open systems for patient feedback, such as Care Opinion, may be more effective in helping online systems evolve. Lastly, we question the need for GP websites and suggest that national or regional services are better placed to maintain accessible services.
Refining sonographic criteria for paediatric appendicitis: combined effects of age-based appendiceal size and secondary findings
Authors: Neal Jeffrey T , Monuteaux Michael C , Rangel Shawn J , Barnewolt Carol E , Bachur Richard G 
Published: March 2022

ObjectiveAppendiceal diameter is a primary sonographic determinant of paediatric appendicitis. We sought to determine if the diagnostic performance of outer appendiceal diameter differs based on age or with the addition of secondary sonographic findings.MethodsWe retrospectively reviewed patients aged less than 19 years who presented to the Boston Children’s Hospital ED and had an ultrasound (US) for the evaluation of appendicitis between November 2015 and October 2018. Our primary outcome was the presence of appendicitis. We analysed the cases to evaluate the optimal outer appendiceal diameter as a predictor for appendicitis stratified by age (<6, 6 to <11, 11 to <19 years), and with the addition of one or more secondary sonographic findings.ResultsOverall, 945 patients met criteria for inclusion, of which 43.9% had appendicitis. Overall, appendiceal diameter as a continuous measure demonstrated excellent test performance across all age groups (area under the curve (AUC) >0.95) but was most predictive of appendicitis in the youngest age group (AUC=0.99 (0.98–1.00)). Although there was no significant difference in optimal diameter threshold between age groups, both 7- and 8-mm thresholds were more predictive than 6 mm across all groups (p<0.001). The addition of individual (particularly appendicolith or echogenic fat) or combinations of secondary sonographic findings increased the diagnostic value for appendicitis above diameter alone.ConclusionsAppendiceal diameter as a continuous measure was more predictive of appendicitis in the youngest group. Across all age groups, the optimal diameter threshold was 7 mm for the diagnosis of paediatric appendicitis. The addition of individual or combination secondary sonographic findings increases diagnostic performance.
Implementation of a national smoke-free prison policy: an economic evaluation within the Tobacco in Prisons (TIPs) study
Authors: McMeekin Nicola , Wu Olivia , Boyd Kathleen Anne , Brown Ashley , Tweed Emily J , Best Catherine , Craig Peter , Leyland Alastair H , Demou Evangelia , Byrne Tom , Pell Jill , Semple Sean , Sweeting Helen , Graham Lesley , Hunt Kate 
Published: March 2022

ObjectiveTo determine the cost-effectiveness of a smoke-free prison policy in Scotland, through assessments of the trade-offs between costs (healthcare and non-healthcare-related expenditure) and outcomes (health and non-health-related non-monetary consequences) of implementing the policy.DesignA health economic evaluation consisting of three analyses (cost-consequence, cost-effectiveness and cost-utility), from the perspectives of the healthcare payer, prison service, people in custody and operational staff, assessed the trade-offs between costs and outcomes. Costs associated with the implementation of the policy, healthcare resource use and personal spend on nicotine products were considered, alongside health and non-health outcomes. The cost-effectiveness of the policy was evaluated over 12-month and lifetime horizons (short term and long term).SettingScotland’s national prison estate.ParticipantsPeople in custody and operational prison staff.InterventionImplementation of a comprehensive (indoor and outdoor) smoke-free policy.Main outcome measuresConcentration of secondhand smoke, health-related quality of life (health utilities and quality-adjusted life-years (QALY)) and various non-health outcomes (eg, incidents of assaults and fires).ResultsThe short-term analyses suggest cost savings for people in custody and staff, improvements in concentration of secondhand smoke, with no consistent direction of change across other outcomes. The long-term analysis demonstrated that implementing smoke-free policy was cost-effective over a lifetime for people in custody and staff, with approximate cost savings of £28 000 and £450, respectively, and improvement in health-related quality of life of 0.971 QALYs and 0.262, respectively.ConclusionImplementing a smoke-free prison policy is cost-effective over the short term and long term for people in custody and staff.
National Cultural Dimensions and Adoption of the International Financial Reporting Standard (IFRS) for Small and Medium-Sized Entities (SMEs)
Authors: Mhedhbi Karim , Essid Moez 
Published: March 2022

SynopsisThe research problemThis study investigates whether the adoption of the International Financial Reporting Standard (IFRS) for small- and medium-sized entities (SMEs) is linked to national culture.Motivation or theoretical reasoningLittle is known about the role of cultural dimensions in explaining countries’ adoption of the IFRS for SMEs. Focusing on this topic could contribute to a better understanding of the adoption of the IFRS for SMEs and would enrich the international accounting literature. Conducting a specific empirical investigation into the IFRS for SMEs is motivated by the difference between the full IFRS and the IFRS for SMEs, by the inherent characteristics of SMEs, and by differences between the number of countries that adopted the full IFRS and those that have adopted the IFRS for SMEs.The test hypothesesWe used Hofstede’s dimensions of national culture (Power Distance, Individualism, Masculinity, Uncertainty Avoidance, Long-term Orientation, and Indulgence) to capture a country’s culture. We expected that these six dimensions would play a crucial role in countries’ decision to adopt the IFRS for SMEs. Based on previous relevant studies, we developed a research hypothesis for each of the mentioned cultural dimensions.Target populationWe selected the 101 countries included in Hofstede’s study. For each country, we looked at the data available on the IFRS website to identify its position in relation to the IFRS for SMEs. The final sample included 97 countries.Adopted methodologyAfter classifying countries in three groups (Non-Adopters, Voluntary Adopters, and Mandatory Adopters), we performed several statistical regressions with adoption of the IFRS for SMEs as the dependent variable and the cultural dimensions as the relevant independent variables.AnalysesAmong others, we used several logistic regressions to estimate the association between national culture and the use of the IFRS for SMEs. We initially performed a statistical estimation for each of the six dimensions of national culture. Then, we included all cultural dimensions simultaneously. Finally, we performed robustness tests by applying multinomial regressions and focusing on the group of full IFRS adopters.FindingsEmpirical results revealed that the adoption of the IFRS for SMEs was less likely in countries with the highest levels of individualism. This conclusion held for both Mandatory and Voluntary Adopters. In contrast, the other dimensions of national culture were not significant in explaining the adoption of the IFRS for SMEs by national accounting regulators.
Applying Bayesian Analysis Guidelines to Empirical Software Engineering Data: The Case of Programming Languages and Code Quality
Authors: Furia Carlo A. , Torkar Richard , Feldt Robert 
Published: March 2022

Statistical analysis is the tool of choice to turn data into information and then information into empirical knowledge. However, the process that goes from data to knowledge is long, uncertain, and riddled with pitfalls. To be valid, it should be supported by detailed, rigorous guidelines that help ferret out issues with the data or model and lead to qualified results that strike a reasonable balance between generality and practical relevance. Such guidelines are being developed by statisticians to support the latest techniques for
Bayesian
data analysis. In this article, we frame these guidelines in a way that is apt to empirical research in software engineering.

To demonstrate the guidelines in practice, we apply them to reanalyze a GitHub dataset about code quality in different programming languages. The dataset’s original analysis [Ray et al.
55
] and a critical reanalysis [Berger et al.
6
] have attracted considerable attention—in no small part because they target a topic (the impact of different programming languages) on which strong opinions abound. The goals of our reanalysis are largely orthogonal to this previous work, as we are concerned with demonstrating, on data in an interesting domain, how to build a principled Bayesian data analysis and to showcase its benefits. In the process, we will also shed light on some critical aspects of the analyzed data and of the relationship between programming languages and code quality—such as the impact of project-specific characteristics other than the used programming language.

The high-level conclusions of our exercise will be that Bayesian statistical techniques can be applied to analyze software engineering data in a way that is principled, flexible, and leads to convincing results that inform the state-of-the-art while highlighting the boundaries of its validity. The guidelines can support building solid statistical analyses and connecting their results. Thus, they can help buttress continued progress in empirical software engineering research.
Numerical Method to Modify the Fractional-Order Diffusion Equation
Authors: Chen Yunkun 
Published: March 2022

Time or space or time-space fractional-order diffusion equations (FODEs) are widely used to describe anomalous diffusion processes in many physical and biological systems. In recent years, many authors have proposed different numerical methods to solve the modified fractional-order diffusion equations, and some achievements have been obtained. However, to our knowledge of the literature, up to date, all the proposed numerical methods to modify FODE have achieved at most a second-order time accuracy. In this study, we focus mainly on the numerical methods based on numerical integration in order to modify the fractional-order diffusion equation:

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Nutrient Detection Sensors in Seawater Based on ISI Web of Science Database
Authors: Cao Lina , Xiang Hongyong , Xu Jingwen , Gao Yufu , Lin Chenlu , Li Kun , Li Zhiwei , Guo Nana , David P. , He Chunguang , Yang Haijun 
Published: March 2022

Marine ecosystem is increasingly deteriorating. In order to assess anthropogenic influence and instigate appropriate remedial actions, it is still of great significance to develop the technology of sensors applied for nutrient detection (e.g., nitrate, phosphate, and silicate) in seawater. This brief review shows an important direction for the development of nutrient detection sensors in seawater and also the limitations and challenges based on data from the ISI Web of Science database. Being different from previous review papers, in this short critical review paper (1) we unified the unit of limit of detection (LOD) for making the comparison within different researches possible; (2) only the literatures focusing on the technological development of sensors in seawater were used; and (3) not only the detection methods but also the detected analytes and publication years were discussed to supply more valuable information for the development of nutrient sensors applied in seawater. In total, 109 literatures were collected with regard to technological development. The quantity of literatures has increased most during 2011-2020. For analytes, literatures related to nitrate, phosphate, ammonium, and phosphate will continue to increase with more accurate data. For detection methods, spectrophotometry, colorimetry, fluorimetry, and electrochemistry are the most widely used sensors. LODs show thousands of orders. In general, there are lower LOD to nitrite and ammonium and fluorimetry method. Now, for analytes,

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Prediagnostic Levels of Copper and Zinc and Breast Cancer Risk in the ORDET Cohort
Authors: Pala Valeria , Agnoli Claudia , Cavalleri Adalberto , Rinaldi Sabina , Orlandi Rosaria , Segrado Francesco , Venturelli Elisabetta , Vinceti Marco , Krogh Vittorio , Sieri Sabina 
Published: March 2022

Abstract

Background:
Case–control studies show that copper (Cu) is high and zinc (Zn) low in blood and urine of women with breast cancer compared with controls.

Methods:
To assess whether prediagnostic Cu and Zn are associated with breast cancer risk, OR of breast cancer according to Cu, Zn, and Cu/Zn ratio in plasma and urine was estimated in a nested case–control study within the ORDET cohort, using conditional logistic regression adjusted for multiple variables: First 496 breast cancer cases and matched controls, diagnosed ≥2 years after recruitment (to eliminate reverse causation) were analyzed. Then all eligible cases/controls were analyzed with stratification into years from recruitment to diagnosis.

Results:
For women diagnosed ≥2 years, compared with lowest tertiles, breast cancer risk was higher in the highest tertile of plasma Cu/Zn ratio (OR, 1.75; 95% CI, 1.21–2.54) and the highest tertile of both plasma and urine Cu/Zn ratio (OR, 2.37; 95% CI, 1.32–4.25). Risk did not vary with ER/PR/HER2 status. For women diagnosed &lt;2 years, high Cu/Zn ratio was strongly associated with breast cancer risk.

Conclusions:
Our prospective findings suggest that increased Cu/Zn ratio in plasma and urine may be both an early marker of, and a risk factor for, breast cancer development. Further studies are justified to confirm or otherwise our results and to investigate mechanisms.

Impact:
Our finding that prediagnostic Cu/Zn ratio is a strong risk factor for breast cancer development deserves further investigation and, if confirmed, might open the way to interventions to reduce breast cancer risk in women with disrupted Cu/Zn homeostasis.