bluuebunny/crossref_metadata_2025_split huggingface dataset:
Правові засади формування національної армії на початковому етапі Української революції (весна – осінь 1917 року)
Authors: Myshchak  I. M. 
Published: August 2022

Метою статті є аналіз політики Української Центральної Ради, Генерального Секретаріату та військових організаційних структур щодо правового забезпечення формування національної армії на початковому етапі Української революції.
Методологія дослідження побудована на принципах історизму, об’єктивності й усебічного аналізу, а також міждисциплінарних підходах (зокрема, методах історії та правознавства).
Основні результати дослідження. Революційне піднесення першої половини 1917 р. призвело до формування численних патріотично налаштованих організацій українських військових. Більшість із них заявила про готовність формувати власні збройні сили і виступити на захист української державності. Основою легітимності подібних рішень стало визнання військових комітетів спочатку Тимчасовим урядом, а згодом і Українською Центральною Радою. При цьому додатковим елементом легалізації та легітимізації рішень військових про формування Української армії стали ухвали всеукраїнських військових з’їздів та визнання їх резолюцій Центральною Радою, а також включення військових делегатів до складу УЦР. Водночас політика УЦР та УГВК навесні – влітку 1917 р. була дуже обережною по відношенню до центральної російської влади та не виходила за межі окремих вимог національно-культурної автономії. Також керівництво УГВК намагалося погоджувати власні дії із військовим міністром Тимчасового уряду, боячись звинувачення у розвалі фронту та відповідальності за можливу окупацію України військами Четверного союзу. При цьому одним із головних прорахунків УЦР у військовому питанні стала відмова під тиском соціалістичних партій від створення професійної армії та бажання замінити її напівпрофесійними формуваннями «Вільного козацтва» й народною міліцією. Така політика значною мірою деморалізувала боєздатні українські військові частини, тож коли постала нагальна потреба захищати Україну та її владу в особі УЦР від більшовицької армії, – проукраїнських збройних сил залишилося обмаль, що, зрештою, і призвело до поразки українських визвольних змагань.
Legal protection against crime victims from social media Facebook over Roleplayer’s behavior
Authors: Rahmawati R. Yu. D. , Michael  T. 
Published: August 2022

Індонезія є однією з країн з найбільшою кількістю користувачів Інтернету у світі. З розвитком Інтернет-світу людина окрім реального життя включається в кіберспільноту. Соціальні мережі стали необхідністю для сучасного суспільства. Однією з найбільш популярних є Facebook, який надає переваги комунікаційного майбутнього. Facebook містить багато спільнот чи асоціацій, однією з яких є асоціація Рольових гравців (Roleplayers). У Рольовій грі гравці грають ролі уявних або реальних персонажів, спільно створюючи історію.
Метою цього дослідження є з’ясування того, яким чином юридично захищений рольовий гравець, який став жертвою злочину в соціальній мережі Facebook.
Наукова новизна полягає в аналізі законодавчої політики щодо захисту жертв кібербулінгу на основі використання результатів емпіричного дослідження.
Емпіричне дослідження проведене з використанням якісних методів. Застосовано цілеспрямовану техніку вибірки, зосереджену на дослідженні рольового гравця (Roleplayer) у соціальній мережі Facebook.
Висновки. Виходячи з цього дослідження, рольовий гравець (Roleplayer), фанатично ставлячись до певної персони, ідолізує її, створює обліковий запис у соціальній мережі Facebook, ідентифікуючи себе з особою бажаного ідола, після чого взаємодіє та розігрує ролі з іншими рольовими гравцями. Таким чином, рольові ігри є фанатичною діяльністю для своїх кумирів. Розвиток і легкість рольових ігор у Facebook може мати негативні наслідки, одним із яких є поява злочинів, які можуть завдати шкоди іншим гравцям. Злочини, які поширені в рольовій грі, включають: кіберзалякування, словесні сексуальні домагання та шахрайство. Формою правового захисту рольових гравців, які стали жертвами злочинів у соціальних мережах Facebook, є ув’язнення та штрафи для винних.
Положення, що стосуються кібербулінгу, регулюються п. (3) ст. 27 і ст. 45 Закону № 19 від 2016 р., словесні сексуальні домагання в соціальних мережах регулюються п. (1) і (2) ст. 14 Закону № 12 від 2022 р., і шахрайство – п. (1) ст. 28 і п. (2) ст. 45 Закону № 19 від 2016 р., ст. 378 Кримінального кодексу Індонезії.
Однак перешкоди протидії злочинам у цій рольовій грі полягають в анонімності, яка є головною вимогою гри, адже жертва та злочинець не використовують свою справжню особу. Дослідженням робиться акцент на тому, що відсутня спеціальна політики, яка б регулювала безпеку у світі рольових ігор.
Optimal time intervals for vaginal breech births: a case-control study
Authors: Spillane Emma , Walker Shawn , McCourt Christine 
Published: August 2022

Background: Breech births are associated with a high rate of hypoxic injury, in part due to cord occlusion during emergence. Maximum time intervals and guidelines oriented toward earlier intervention have been proposed in a Physiological Breech Birth Algorithm. We wished to further test and refine the Algorithm for use in a clinical trial. Methods: We conducted a retrospective case-control study conducted in a London teaching hospital, including 15 cases and 30 controls, during the period of April 2012 to April 2020. Our sample size was powered to test the hypothesis that exceeding recommended time limits is associated with neonatal admission or death. Data collected from intrapartum care records was analysed using SPSS v26 statistical software. Variables were intervals between the stages of labour and various stages of emergence (presenting part, buttocks, pelvis, arms, head). The chi-square test and odds ratios were used to determine association between exposure to the variables of interest and composite outcome. Multiple logistic regression was used to test the predictive value of delays defined as non-adherence the Algorithm. Results: Logistic regression modelling using the Algorithm time frames had an 86.8% accuracy, a sensitivity of 66.7% and a specificity of 92.3% for predicting the primary outcome. Delays between umbilicus and head >3 minutes (OR: 9.508 [95% CI: 1.390-65.046] p=0.022) and from buttocks on the perineum to head >7 minutes (OR: 6.682 [95% CI: 0.940-41.990] p=0.058) showed the most effect. Lengths of time until the first intervention were consistently longer among the cases. Delay in intervention was more common among cases than head or arm entrapment. Conclusion: Emergence taking longer than the limits recommended in the Physiological Breech Birth algorithm is predictive of adverse outcomes. Some of this delay is potentially avoidable. Improved recognition of the boundaries of normality in vaginal breech births may help improve outcomes.
Dispositions of Technological Knowledge in Teacher Candidates – An Analysis of Predictors
Authors: Johnson Frederick , Koβmann Joanna 
Published: August 2022

In this paper, the impact of broader and more specific dispositions on technological knowledge (TK) in teacher candidates is analyzed. TK is the fundament on which the technological pedagogical and content knowledge (TPACK) model is built on. According to contemporary behavioral competence theory, the predictors will be tested as cognitive, affective and conative dispositions for TK. Thus, multiple regression models are utilized to test according predictors of performance based and self-reported TK as criteria (n = 460). In the first model, broader sense predictors such as general self-efficacy, basic motives, intelligence and personality are introduced as predictors. The second model adds more specific predictors such as technology commitment, motives, attitudes concerning information and communications technology (ICT). The third model adds private and study related technology use with different devices. A precedent base model controls for gender and age. For performance-based TK as dependent measure, the third model (R2 = .261) indicates that intelligence, extraversion, negative attitudes towards ICT and the private use of a PC function as the most powerful predictors. In explaining self-reported TK, the second model (R2 = .280) indicates that technology commitment and negative attitudes towards ICT are predictors. In conclusion, the prediction pattern between performance-based and self-reported TK differs. An explanation might be a practice effect from actual technology use.
Sensory Design and Design Thinking for Design Educating
Authors: Zi Mengnan 
Published: August 2022

This paper aims to highlight the critical role of the interdisciplinary integration of sensory design and design thinking in education, particularly in educating designers. Through a literature review analysis, the paper explicates the importance of integrating sensory design and design thinking in design education and puts forward a didactic method to deal with specific problems encountered in design education. A case study conducted at the Sichuan Fine Arts Institute has been used as an experiment for a new didactic method. Students could choose any material and explored its sensory expressions, discovering emotional and narrative content. Then, students selected traditional handicrafts to enhance and add new sensory expressions, reinforcing and clarifying the emotional expressions. Ultimately defined the design theme and students' work were the final output. The purpose is to summarise the results and problems of teaching activities through an analysis of course content. The didactic method emphasises the student experience and the innovative design outcome. The didactic method was tested in design education, suggests possible development trends in the application of interdisciplinary education to provide the impetus for improving existing design education models.
Dissection of the macrophage response towards infection by the Leishmania-viral endosymbiont duo and dynamics of the type I interferon response
Authors: Bekkar Amel , Isorce Nathalie , Snäkä Tiia , Claudinot Stéphanie , Desponds Chantal , Kopelyanskiy Dmitry , Prével Florence , Reverte Marta , Xenarios Ioannis , Fasel Nicolas , Teixeira Filipa 
Published: August 2022

Leishmania RNA virus 1 (LRV1) is a double-stranded RNA virus found in some strains of the human protozoan parasite Leishmania, the causative agent of leishmaniasis, a neglected tropical disease. Interestingly, the presence of LRV1 inside Leishmania constitutes an important virulence factor that worsens the leishmaniasis outcome in a type I interferon (IFN)–dependent manner and contributes to treatment failure. Understanding how macrophages respond toward Leishmania alone or in combination with LRV1 as well as the role that type I IFNs may play during infection is fundamental to oversee new therapeutic strategies. To dissect the macrophage response toward infection, RNA sequencing was performed on murine wild-type and Ifnar-deficient bone marrow–derived macrophages infected with Leishmania guyanensis (Lgy) devoid or not of LRV1. Additionally, macrophages were treated with poly I:C (mimetic virus) or with type I IFNs. By implementing a weighted gene correlation network analysis, the groups of genes (modules) with similar expression patterns, for example, functionally related, coregulated, or the members of the same functional pathway, were identified. These modules followed patterns dependent on Leishmania, LRV1, or Leishmania exacerbated by the presence of LRV1. Not only the visualization of how individual genes were embedded to form modules but also how different modules were related to each other were observed. Thus, in the context of the observed hyperinflammatory phenotype associated to the presence of LRV1, it was noted that the biomarkers tumor-necrosis factor α (TNF-α) and the interleukin 6 (IL-6) belonged to different modules and that their regulating specific Src-family kinases were segregated oppositely. In addition, this network approach revealed the strong and sustained effect of LRV1 on the macrophage response and genes that had an early, late, or sustained impact during infection, uncovering the dynamics of the IFN response. Overall, this study contributed to shed light and dissect the intricate macrophage response toward infection by the Leishmania-LRV1 duo and revealed the crosstalk between modules made of coregulated genes and provided a new resource that can be further explored to study the impact of Leishmania on the macrophage response.
Angiotensin receptor-neprilysin inhibitor therapy and recurrence of atrial fibrillation after radiofrequency catheter ablation: A propensity-matched cohort study
Authors: Dong Youzheng , Xiao Shucai , He Jinwu , Shi Kaixin , Chen Si , Liu Deping , Huang Bin , Zhai Zhenyu , Li Juxiang 
Published: August 2022

BackgroundCompared with conventional medicines, angiotensin receptor-neprilysin inhibitor (ARNI) could further improve the prognosis for multiple cardiovascular diseases, such as heart failure, hypertension, and myocardial infarction. However, the relationship between ARNI therapy and the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation is currently unknown.MethodsThis study is a retrospective cohort study. Patients with consecutive persistent or paroxysmal AF undergoing first-time radiofrequency ablation were enrolled from February 2018 to October 2021. We compared the risk of AF recurrence in patients with catheter ablation who received ARNI with the risk of AF recurrence in those who received the angiotensin-converting enzyme inhibitor (ACEI). The propensity-score matched analysis was conducted to examine the effectiveness of ARNI. We used a Cox regression model to evaluate AF recurrence events.ResultsAmong 679 eligible patients, 155 patients with ARNI treatment and 155 patients with ACEI treatment were included in the analyses. At a median follow-up of 228 (196–322) days, ARNI as compared with ACEI was associated with a lower risk of AF recurrence [adjusted hazard ratio (HR), 0.39; 95% confidence interval (CI), 0.24–0.63; p &lt; 0.001]. In addition, no interaction was found in the subgroup analysis.ConclusionAngiotensin receptor-neprilysin inhibitor treatment was associated with a decreased risk of AF recurrence after first-time radiofrequency catheter ablation.
Association between hypertriglyceridemic-waist phenotype and cardiovascular disease: A cohort study and meta-analysis
Authors: Zheng Xiaowei , Ren Xiao , Jiang Minglan , Han Longyang 
Published: August 2022

BackgroundThe association between hypertriglyceridemic-waist (HTGW) phenotype and cardiovascular disease (CVD) remains inconsistent and debatable. We aimed to prospectively investigate the relationship between HTGW phenotype and CVD.Methods and resultsWe included 8,216 participants from the China Health and Retirement Longitudinal Study. Participants were categorized into four subgroups: NTNW: normal triglyceride levels and normal waist circumference; HTNW: high triglyceride levels and normal waist circumference; NTGW: normal triglyceride levels with enlarged waist circumference; HTGW: high triglyceride levels and enlarged waist circumference. A Cox proportional hazards model was applied to determine the association between HTGW phenotype and CVD. A meta-analysis was conducted to incorporate the results of the current study and the previous-related studies on the association of HTGW phenotype and CVD. In the present cohort study, compared to the NTNW phenotype, those with NTGW (Hazard ratios (HRs) 1.34, 95% confidence intervals (CIs) 1.16–1.55) and HTGW (HRs 1.37, 95% CIs 1.16–1.62) phenotype were significantly associated with CVD risk. The meta-analysis further confirmed the significant association between HTGW phenotype and CVD [the pooled relative risk for HTGW vs. NTNW was 1.39 (1.29–1.49)].ConclusionThe HTGW phenotype was associated with the increased risk of CVD, independently of established risk factors. A simple assessment of HTGW phenotypes might help to identify individuals with a high risk of developing CVD.
Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis
Authors: Li Haobo , Zhang Zhu , Weng Haoyi , Qiu Yuting , Zubiaur Pablo , Zhang Yu , Fan Guohui , Yang Peiran , Vuorinen Anna-Leena , Zuo Xianbo , Zhai Zhenguo , Wang Chen 
Published: August 2022

ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial. Hence, a systematic review was performed to study the association between CES1 rs2244613 genotype and the PKs and safety of dabigatran and CES1 relative expression.MethodsIn addition to the three English databases (Web of Science, PubMed, and Embase), two Chinese databases (CNKI and Wanfang) were thoroughly revised. The mean differences (MD) and corresponding 95% confidence intervals (CI) were applied to evaluate the differences in PKs between the CES1 rs2244613 genotype. Odds ratio (OR) was used to study the risk for bleeding events between the CES1 rs2244613 genotypes. Subsequent expression quantitative trait loci (eQTL) analyses were performed to evaluate genotype-specific expressions in human tissues.ResultsTen studies (n = 2,777) were included. CES1 rs2244613 G allele carriers exhibited significantly lower dabigatran trough concentrations compared to T allele carriers (MD: −8.00 ng/mL; 95% CI: −15.08 to −0.92; p = 0.03). The risk for bleeding events was significantly lower in carriers of the G allele compared to T allele carriers (OR: 0.65; 95% CI: 0.44–0.96; p = 0.03). Subsequent eQTL analysis showed significant genome-wide expressions in two human tissues, whole blood (p = 5.1 × 10–10) and liver (p = 6.2 × 10–43).ConclusionOur meta-analysis indicated a definite relation between the CES1 rs2244613 genotype and tolerability variations or pharmacokinetic fluctuations. The carriers of T allele showed higher dabigatran concentrations; therefore, they would benefit from a dose reduction.Systematic review registration[https://inplasy.com/inplasy-2022-6-0027/], identifier [NPLASY202260027].
Clinical presentation and cardiac imaging findings in patient cases of perimyocarditis and pericarditis with a temporal association to SARS-CoV-2 vaccination
Authors: Pedersen Anders Lehmann Dahl , Wood Gregory , Frederiksen Christian Alcaraz , Løgstrup Brian Bridal , Jensen Morten Kvistholm , Østergaard Lars , Kim Won Yong , Poulsen Steen Hvitfeldt 
Published: August 2022

AimsWe aimed to investigate and present cases of perimyocarditis and pericarditis verified by cardiovascular resonance (CMR) imaging in patients with a strong temporal association to SARS-CoV-2 vaccination. We sought to describe the clinical presentation including coronary artery angiography, CMR, transthoracic echocardiography, blood samples, electrocardiography, and symptoms.MethodsWe included 10 patients admitted with chest pain shortly after vaccination for SARS-CoV-2, who were diagnosed with pericarditis or perimyocarditis by CMR. We reviewed the CMR, echocardiography, electrocardiography, blood samples, coronary artery angiography, vital signs and medical history. The updated Lake Louise Criteria were used to determine the diagnosis by CMR.ResultsEight patients had perimyocarditis and two patients had pericarditis. The mean age was 22 ± 5 years (range 16 to 31 years), 90% were male. The median time from vaccination to hospital admission was 4 days (range 2 to 28 days). Admissions were seen after vaccination with three different SARS-CoV-2 vaccine manufacturers. Nine Patients had ST-elevation on the initial electrocardiography. Peak troponins varied from 357 to 23,547 ng/l, with a median of 4,304 ng/l. Two patients had an LVEF &lt;50% on echocardiography and four patients had left ventricular global longitudinal strain values &lt;18%. CMR revealed preserved left ventricular ejection fraction (LVEF), although one patient had decreased LVEF on CMR. The T1 and T2 mapping values were increased in all patients. Of the 8 patients with perimyocarditis, all patients had signs of myocardial injury in the lateral segments of the left ventricle.ConclusionsThis case series of 10 patients supports the emerging evidence of an association between vaccination for SARS-CoV-2 and perimyocarditis and pericarditis, especially in young males. The temporal association was seen after vaccines from three different manufacturers. Imaging data from echocardiography and CMR displayed normal to mildly impaired cardiac function, usually with a mild disease course.
Nomogram and risk calculator for severe hypoxemia after heart valve surgery
Authors: Ding Xiangchao , Cheng Dan , Sun Bing , Sun Manda , Wu Chuangyan , Chen Jiuling , Li Xiaoli , Lei Yuan , Su Yunshu 
Published: August 2022

BackgroundHypoxemia is a very common issue in patients undergoing heart valve surgery (HVS), related to poor clinical outcomes. However, studies on severe hypoxemia (SH) after HVS have not been reported. The aims of this study were to identify predictors for SH in patients undergoing HVS and to develop and validate a risk prediction model.MethodsPatients undergoing HVS between 2016 and 2019 in a cardiovascular center were enrolled and were assigned to training and validation sets by a 7:3 ratio. Based on whether patients developed SH, they were divided into two groups. By univariate and multivariate analysis, predictors for SH were identified. Based on the predictors and logistic rule, a nomogram and a risk calculator were generated. The model was evaluated using calibration, discrimination and clinical utility.ResultsThe incidence rates of SH, moderate hypoxemia and mild hypoxemia were respectively 2.4, 23.9, and 58.2%. By multivariate analysis, seven independent risk factors for SH after HVS were identified, including body mass index, chronic obstructive pulmonary disease, renal insufficiency, white blood cell count, serum globulin, cardiopulmonary bypass time, and surgical types. The logistic model demonstrated satisfactory discrimination, calibration and clinical utility in both the training and validation sets. A nomogram and a risk calculator based on the logistic model were generated for easy application. Risk stratification was performed and three risk intervals were defined according to the nomogram and clinical practice. In addition, compared to patients without SH, patients with SH had significantly poorer clinical outcomes.ConclusionsPostoperative hypoxemia was prevalent after HVS, related to poor clinical outcomes. A logistic model including seven independent predictors for SH after HVS were established and validated, which demonstrated satisfactory discrimination, calibration and clinical utility. The results of this study may provide help to individualized risk assessment, early prevention and perioperative management.