bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gouvernance des services d’eau potable et d’assainissement dans la commune de Koudougou, Burkina Faso
Authors: Nansi Juste Hermann , Dahani Dramane 
Published: November 2022

La commune de Koudougou à l’instar des autres communes du pays exerce la maîtrise d’ouvrage dans le domaine de l’eau potable et de l’assainissement. Mais, la question des ressources pour l’exercice de ces compétences est loin d’être tranchée. Pour présenter l’état des lieux de la gouvernance de ces services dans la commune de Koudougou, la méthodologie adoptée a consisté à faire une revue documentaire, des entretiens auprès des personnes ressources intervenants dans l’AEPHA et une enquête sur 518 ménages. Les résultats de l’étude montrent un faible engagement de l’autorité communale qui se traduit par une faible structuration des services en charge de l’AEPHA et leur faible dotation en ressources humaines, financières et matérielles ; une gestion des ouvrages d’AEPHA non conforme aux principes du document cadre de gestion du service public de l’eau potable en milieu rural au Burkina; une absence de stratégie de mobilisation de financements pour l’AEPHA ; un financement de l’AEPHA à hauteur de 2,05% du montant total du budget alloué sur la période 2016 à 2019.
The commune of Koudougou, like the other communes in the country, is in charge of drinking water and sanitation. However, the question of resources for the exercise of these competencies is far from being settled. To present the state of play of the governance of these services in the commune of Koudougou, the methodology adopted consisted of a literature review, interviews with resource persons involved in WASH and a survey of 518 households. The results of the study show a weak commitment of the communal authority, which is reflected in the poor structuring of the services in charge of WASH and their low allocation of human, financial and material resources; management of WASH facilities that does not comply with the principles of the framework document for the management of the public drinking water service in rural areas in Burkina; an absence of a strategy for mobilizing funding for WASH; and funding for WASH of 2.05% of the total amount of the budget allocated over the period 2016 to 2019. Communal governance of the sub-sector and WASH services is not very operational and would benefit from being revitalized.
MiR-22 alleviates the proliferation and metastasis of melanoma by targeting FASN
Authors: Qiu Jun , Yi Yanhua , Miao Yong , Hu Zhiqi 
Published: November 2022

Purpose: To determine the role of microRNA-22 (miR-22) in the development of malignant melanoma, and the underlying mechanism.
Methods: Potential miRNAs binding fatty acid synthase (FASN) were predicted by bioinformatics analysis, out of which miR-22 was selected. Their binding relationship was confirmed using dual-luciferase reporter assay. MicroRNA-22 and FASN levels in 40 clinical samples of melanoma were determined, and the correlation of the expression between miR-22 and FASN was assessed by Pearson correlation test. To uncover the role of miR-22 in regulating cell phenotypes of malignant melanoma, M21 and A375 cells were transfected with miRNA-NC, miR-22 mimics or miR-22 mimics + FASN-OE (FASN-over expression), respectively. Proliferative and metastatic abilities in each group were determined using cell counting kit-8 (CCK-8), 5-Ethynyl-2’- deoxyuridine (EdU) and Transwell assay, respectively.
Results: MiR-22 was the target gene binding the oncogene, FASN. Downregulated miR-22 and upregulated FASN were observed in melanoma tissues, showing a negative correlation between them. An overexpression of miR-22 significantly inhibited proliferative, migratory and invasive capacities in M21 and A375 cells (p < 0.05). Notably, overexpression of FASN abolished the inhibitory effects of miR-22 on proliferative and metastatic abilities in melanoma.
Conclusion: The level of expression of miR-22 in the malignant melanoma samples is low. Overexpression of miR-22 inhibits the proliferative and metastatic abilities of melanoma by targeting FASN and negatively regulating its level. Thus, miR-22 may be a promising therapeutic target of melanoma.
Polypharmacy-related polypathology in the elderly: A case study at Ibn Sina Hospital, Morocco
Authors: Bouaoudate Mostafa , El harti Jaouad , Abouqal Redouane , Abidi Khalid , Zeggwagh Amine Ali 
Published: November 2022

Purpose: To determine the polypathological and therapeutic profiles of a population of elderly subjects at the Ibn Sina Hospital, Rabat, Morocco.
Methods: This was a prospective cross-sectional observational study on a population made up of 356 patients aged ≥ 65 years. Data were collected from different departments during the study period, regarding age, sex, educational level, socio-cultural and economic status, self-care ability, polypathologies, polymedication, effectiveness of treatments, adverse effects, and knowledge of the concept of generic medication. The results, which are presented in percentages and simple averages, were processed with Excel 2016 software.
Results: Patients aged 66 - 75 years comprised 60.4 % of the studied population. The most common pathologies were diabetes, asthma, and cardiovascular disease. A total of 237 patients (66.6 %) took < 6 drugs, while 119 patients (33.4 %) were on polypharmacy, i.e., > 6 drugs. The elderly were more vulnerable to polypathology and polypharmacy due to age-related reduction in physiological functions and their impact on pharmacological parameters. Polypathology led to polypharmacy which increased the risk of side effects and problems with adherence to medications.
Conclusion: This study provides information on the pathological profiles of a population of elderly subjects in a Moroccan hospital, and details of the therapeutic strategies used in managing these patients.
Drug-related problems and health-related quality of life among chronic disease patients in a rural region of North Cyprus
Authors: Goksin Servet , Abdi Abdikarim , Alsaloumi Louai , Basgut Bilgen 
Published: November 2022

Purpose: To evaluate the various types of drug-related problems (DRPs) and health-related quality of life (HRQoL) among chronic disease patients in a rural region of North Cyprus.
Methods: A cross-sectional study of patients visiting a rural community pharmacy in North Cyprus was conducted. Patient demographic information, quality of life (QoL), laboratory data, adherence, and beliefs about medicine were assessed using standardized tools. Drug-related problems were evaluated using PCNE V.9.1.
Results: Among the 200 screened participants, 97 fulfilled the enrollment criteria and were interviewed. The median age of the participants was 62 years (interquartile range = 15), with 58.8 % women. Only 54 % of hypertensive (HTN) patients reached their target blood pressure level. Over 40 % of type 2 diabetes mellitus (T2DM) patients failed to achieve their target HbA1c level. The majority (71 %) of patients with HTN, T2DM or coronary artery disease were not compliant with lifestyle recommendations and 86.6 % had ≥ 1 DRP. Insufficient dosing and inappropriate indication for a drug were the DRPs associated with failure to achieve target and inappropriate drugs was the DRP type mostly associated with lower quality of life scores. Other factors associated with lower QoL levels included female gender, unemployment status, and high agreement with the statement “medications do more harm than good”.
Conclusion: Drug related problems and non-adherence are prevalent, while therapy targets are rarely met in rural Cyprus. Community pharmacists have the potential to improve outcomes in the management of non-communicable diseases (NCDs).
Diagnostic value of multi-slice spiral computed tomography after adiponectin treatment of tracheal malignancies
Authors: Liu Jian , Zu Degui , Yang Ying , Deng Maosong , Deng Gang , Chang Xin , Yin Xiaoming 
Published: November 2022

Purpose: To determine the diagnostic value of multi-slice spiral computed tomography (CT) after adiponectin treatment of tracheal malignancies.
Methods: Sixty patients with tracheal malignancies admitted to Emergency General Hospital from February 2017 to February 2021 were assigned to the study group. After physical examination, 60 healthy subjects in the same period served as the control group. All patients were treated with adiponectin. The control group was subjected to serum tumor marker testing before and after treatment, while the study group received multi-slice spiral CT before and after adiponectin treatment.
Results: The 60 patients enrolled in the study group comprised 30 cases of squamous carcinoma, 22 cases of adenocarcinoma, and 8 cases of mucosa-associated lymphoma. Multi-slice spiral CT before treatment showed that 35 patients with tracheal malignant tumors had expansive lumen hyperplasia, while 25 patients with bulging tumors had saddle-like hyperplasia with irregular surfaces, uneven margins, and mean thickness of 5.96 ± 0.65 mm in the tracheal and bronchial walls adjacent to the luminal nodule. After treatment, the thickness of the tracheal and bronchial walls adjacent to the luminal nodule decreased to a mean value of 4.65 ± 0.48 mm. Prior to treatment, the mean enhancement value of contrast-enhanced CT was 18.98±1.23 Hu, and mean tumor diameter was 3.68 ± 0.23 cm. However, after treatment, the mean enhancement value increased to 25.98 ± 1.44 Hu, while mean tumor diameter decreased to 2.54 ± 0.20 cm in the study group.
Conclusion: Multi-slice spiral CT has promising diagnostic value for patients with tracheal malignancies after adiponectin treatment. Therefore, it can potentially be used in the diagnosis of patients with tracheal malignancies.
Volumetric-modulated arc therapy as an alternative to intensity-modulated radiotherapy for primary tumors of advanced non–small-cell lung cancer: A multicenter retrospective analysis based on propensity score matching
Authors: Liu Jie , Li Tao , Wang Xiaohu , Su Shengfa , Li Qingsong , Geng Yichao , Yang Wengang , Chen Xiaxia , Ouyang Weiwei , Zhang Wei , Lu Bing 
Published: November 2022

Purpose: To investigate the effect of volumetric-modulated arc therapy (VMAT) versus intensity-modulated radiotherapy (IMRT) for advanced non–small-cell lung cancer (NSCLC).
Methods: Cases in which the primary tumors were treated with IMRT or VMAT as initial intervention in stages III and IV NSCLC patients from September 2008 to March 2020 were retrospectively analyzed. Propensity Score Matching (PSM) was used to assess the efficacy and toxicity of the two radiotherapy techniques.
Results: A total of 637 patients were included, out of which 483 cases were treated with IMRT, while 154 received VMAT. A total of 308 patients were selected after PSM. Patients who were having acute radiation esophagitis and pneumonia treated with VMAT had a lower percentage than those treated with IMRT (p < 0.05) before PSM. However, there was no significant difference in grades 3 - 4 toxicity (χ2 = 2.77, p = 0.096). There were also no significant differences in the primary endpoints between the two groups after PSM (p > 0.05), while for secondary endpoints, all lung V5, and V20, mean lung dose and heart V30, heart V40, mean heart dose in all patients and stage N2 patients in VMAT after PSM were significantly lower than those of IMRT (p < 0.05).
Conclusion: Radiation therapy of A-NSCLC primary tumors using VMAT and IMRT seem to produce similar efficacy. The volume parameters of normal tissues and organs is significantly lower in VMAT, especially in patients with stage N2. Therefore, VMAT may be more beneficial for reducing radiation damage in normal tissues and organs.
Characteristics of basal gastric juice in Helicobacter pylori-associated gastritis before and after eradication therapy
Authors: Nguyen Sam Phan Hai , Do Tho Chau Minh Vinh , Tran Tam Thai Thanh , Pham Tho Kieu Anh , De Tran Van , Nguyen Kien Trung 
Published: November 2022

Purpose: To evaluate the characteristics of basal gastric juice in Helicobacter pylori-positive patients before and after Helicobacter pylori eradication therapy.
Methods: This was a cross-sectional descriptive study on 150 gastritis patients admitted at the Hospital of Can Tho University of Medicine and Pharmacy. The patients were divided into 2 groups: study group (Helicobacter pylori gastritis patients) and control group (non-Helicobacter pylori gastritis patients). The pH, HCO3- concentration, and activities and concentrations of pepsin, lipase, and amylase were determined before and after treatment in study group.
Results: Patients with abnormal gastric juice comprised 76 % of the study population. Mean gastric potential of hydrogen (pH) was 2.31 (range: 1.64 - 7.68), while median concentration of HCO3- was 4.06 mmol/L (range: 0 - 73.04 mmol/L). The concentrations of pepsin, lipase, and amylase were 8.93, 0.93 and 1.38 ppm, respectively. Activities of pepsin, lipase, and amylase were 2.23, 0.28 and 0.04 U/mL, respectively. After the successful eradication of Helicobacter pylori, pH and HCO3- levels decreased, and there were significant differences in activities of pepsin and lipase before and after treatment (p < 0.05). Moreover, the levels of these parameters differed between patients in whom successful eradication was achieved and those in whom eradication failed (p < 0.05). The concentrations and activities of pepsin and lipase were statistically different between pre-treatment and post-treatment stages in both successful and failed Helicobacter pylori eradication categories (p < 0.05).
Conclusion: Basal gastric juice differs significantly between Helicobacter pylori-positive and Helicobacter pylori-negative patients. Intragastric ammonia produced by H. pylori may have a role in the increased pH of gastric juice.
Ginsenoside induces apoptosis, autophagy and cell cycle arrest in gastric cancer cells by regulation of reactive oxygen species and activation of MAPK pathway
Authors: Lu Jingfen , Yang Lin , Zhu Qicong , Gao Peng , Zhang Zhengyi , Wang Wei , Fu Yongsheng 
Published: November 2022

Purpose: To study the influence of ginsenoside on apoptosis, cell cycle and autophagy in gastric carcinoma (GC), and its effect on reactive oxygen species (ROS) levels and the mitogen-activated protein kinase (MAPK) pathway.
Methods: Human gastric cancer cell line BGC-823 was randomly divided into the following groups: control, 100 μM ginsenoside (Rg5), 150 μM Rg5, and 200 μM Rg5 groups. Western blot assay was used to determine the expressions of autophagy-associated protein 12 (Atg12), Beclin-1, lc3b II, cycle-related protein, phosphated mitotic cyclin 25 homologous protein C (p-cdc25c), cyclin B1, and MAPK signaling pathway-related proteins.
Results: There was significantly higher apoptosis in Rg5-treated BGC-823 cells than in untreated cells. Relative protein levels of Beclin-1, Atg5, Atg12, and lc3b II in BGC-823 cells in Rg5 groups were significantly and concentration-dependently up-regulated, relative to the corresponding expression levels in untreated cells. There were markedly up-regulated proteins of p-cdc25c, cyclin B1 and p-cdc2 in Rg5-exposed BGC-823 cells than in untreated cells, while CDC2 protein expression was significantly and concentration-dependently lower than that of control group (p < 0.05). Rg5 treatment resulted in marked and concentration-dependent increases in ROS levels in BGC-823 cells, relative to control cells (p < 0.05), whereas the expression levels of p-p38, p-JNK and p-ERK were significantly higher in Rg5-exposed cells than in unexposed cells (p < 0.05).
Conclusion: Ginsenoside induces apoptosis, autophagy and cycle interruption in GC cells by regulating ROS production and activating MAPK pathway. Therefore, ginsenoside may be a promising agent for the management of gastric cancer. However, there is a need to conduct in vivo studies on the compound.
Enfermedad renal crónica: Alcance y perspectiva etnobotánica
Authors: Carvajal-Zarrabal Octavio , Barradas-Dermitz Dulce María , Nolasco-Hipólito Cirilo , Ajibola Olaide Olawunmi , Calderon-Garcidueñas Ana Laura , López-Amador Noé 
Published: November 2022

En México y a nivel mundial existe un interés creciente en la búsqueda de alternativas de prevención y tratamiento de las enfermedades renales crónicas (ERC), que representan un problema de salud pública. El tratamiento actual para la ERC se limita a esteroides, citotóxicos y tratamiento sustitutivo dependiendo del estadio de la enfermedad. La Medicina alternativa y específicamente la herbolaria, ha utilizado plantas para los padecimientos renales y algunos de sus mecanismos de acción han sido estudiados, sin embargo, se requiere que presenten efectos adversos mínimos. Utilizando la base de datos de Scopus, Medline, y PubMed, se realizó una revisión de la literatura sobre recursos etnobotánicos utilizados en el tratamiento de la ERC en modelos murinos con daño renal inducido por administración de adenina. Se ha reportado que Astragalus membranaceus y Acacia senegal (goma arábiga), son efectivas en la prevención o remisión de la ERC; sin embargo,Anthurium schelechetendalii Kunth, que también se menciona en la literatura, porque ha sido usada como terapia herbolaria por población local en México, no ha mostrado hasta el momento utilidad terapéutica para prevenir o tratar daño renal, en estudios preliminares. Tampoco hay evidencia científica de sus características químicas o actividades biológicas ni acerca de los diferentes usos en la herbolaria mexicana. Esta revisión, tiene objetivo enmarcar el problema de la insuficiencia renal crónica en México e iniciar la documentación de la evidencia científica de esta planta en base a los escasos datos etnobotánicos y etnofarmacológicos disponibles.
HANDBOOK OVERWEIGHT DAPAT MENURUNKAN ASUPAN LEMAK DAN BERAT BADAN REMAJA
Authors: Abadi Ellyani , Fatmawati Fatmawati , Kameriah Kameriah , Abdurrakhman Abdurrakhman , Supryatno Adi 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh handbook overweight terhadap asupan lemak dan berat badan remaja di sekolah menengah pertama swasta Frater Kendari Sulawesi Tenggara. Metode penelitian ini adalah pre ekperiment menggunakan pre test-post test design. Sampel sebanyak 32 remaja overweight. Pengumpulan data berat badan menggunakan timbangan injak yang terkalibrasi dan asupan lemak menggunakan form recall 3 x 24 jam. Data diukur sebanyak 4 kali dan dianalisis menggunakan uji paired T-test. Hasil uji statistik menunjukkan bahwa ada pengaruh handbook overweight terhadap asupan lemak remaja dengan nilai p value 0,000 < 0.05 (CI 95%) dan ada pengaruh handbook overweight terhadap berat badan remaja dengan nilai p value 0,000 < 0.05 (CI 95%). Kesimpulan penelitian yaitu Handbook Overweight dapat menurunkan asupan lemak dan berat badan remaja
PERANCANGAN APLIKASI MANAJEMEN KEUANGAN BADAN EKSEKUTIF MAHASISWA AMIK IBNU KHALDUN PALOPO
Authors: SABILA SAL , ILMAN NUR , SAYUTI NUR LAELA , RIZAL MUHAMMAD 
Published: November 2022

Finance is a very important part because almost all existing activities require money. Finances also need to be regulated as well as possible, for that we need good financial management. The application of information systems provides financial benefits for BEM, especially for financial management of income and expenses. Problem analysis was carried out to find out problems in BEM's finances, to detect financial income and expenses at AMIK BEM. This study aims to design the financial management application of BEM AMIK Ibnu Khaldun Palopo. In making this application program using the PHP language, MySQL as a database and using the CodeIgniter framework. The author uses UML (Unified Modeling Language) modeling and the method used is the waterfall method. From this research, the Financial Management Application of AMIK Ibnu Khaldun Palopo Student Executive Board can be created.
ABSTRAKKeuangan merupakan bagian yang sangat penting karena hampir semua kegiatan yang ada membutuhkan uang. Keuangan juga perlu diatur sebaik-baiknya, untuk itu diperlukan manajemen keuangan yang baik. Penerapan sistem informasi memberikan manfaat bagi keuangan BEM terutama untuk pengelolaan keuangan pemasukan dan pengeluaran. Analisa permasalahan dilakukan untuk mengetahui masalah pada keuangan BEM, untuk mendeteksi pemasukan dan pengeluaran keuangan pada BEM AMIK. Penelitian ini bertujuan untuk merancang aplikasi manajemen keuangan BEM AMIK Ibnu Khaldun Palopo. Dalam pembuatan program aplikasi ini menggunakan bahasa PHP, MySQL sebagai database dan menggunakan framework CodeIgniter. Penulis menggunakan pemodelan UML (Unified Modelling Language) dan metode yang digunakan yaitu metode waterfall. Dari penelitian inilah dapat terciptanya Aplikasi Manajemen Keuangan Badan Eksekutif Mahasiswa AMIK Ibnu Khaldun Palopo.
Your Tweets Matter:
Authors: Mustata Wilson Gabriela , Aleksandric Ana , Obasanya Mercy Jesuloluwa , Melcher Sarah , Nilizadeh Shirin 
Published: November 2022

Objective: The aims of the study were to examine the association between social media sentiments surrounding COVID-19 vaccination and the effects on vaccination rates in the United States (US), as well as other contributing factors to the COVID-19 vaccine hesitancy.
Method: The dataset used in this study consists of vaccine-related English tweets collected in real-time from January 4 - May 11, 2021, posted within the US, as well as health literacy (HL), social vulnerability index (SVI), and vaccination rates at the state level.
Results: The findings presented in this study demonstrate a significant correlation between the sentiments of the tweets and the vaccination rate in the US. The results also suggest a significant negative association between HL and SVI and that the state demographics correlate with both HL and SVI.
Discussion: Social media activity provides insights into public opinion about vaccinations and helps determine the required public health interventions to increase the vaccination rate in the US.
Conclusion: Health literacy, social vulnerability index and monitoring of social media sentiments need to be considered in public health interventions as part of vaccination campaigns.
Keywords: COVID–19, Health Literacy, COVID–19 Vaccine Hesitancy, Social Vulnerability Index, Social Media, Social Determinants of Health
Abbreviations: Health Literacy (HL), Social Vulnerability Index (SVI), Social Determinants of Health (SDOH), United States (US)
Correspondence: gabriela.wilson@uta.edu
PENGARUH KESEHATAN LINGKUNGAN TERHADAP LAJU ENDAP DARAH DAN JUMLAH LIMFOSIT PADA PENDERITA TUBERKULOSIS
Authors: Hepiyansori Hepiyansori 
Published: November 2022

ABSTRAKÂ Penelitian ini dengan tujuan mengetahui gambaran pemeriksaan laju endap darah (LED) dan jumlah limfosit pada penderita Tuberkulosis dengan memperhatikan faktor kesehatan lingkungan diwilayah kerja puskesmas sukamerindu. Dengan sampel 17 positif penderita Tuberkulosis (TBC) di Puskesmas Sukamerindu. DenganÂ teknik pengambilan sampel yaitu Total Sampling dengan hasil penelitian adalah pemeriksaan nilai LED menggunakan Larutan Natrium Citrat 3,8% dengan sampel 17 positif penderita Tuberkulosis (TBC) diÂ Puskesmas Sukamerindu di dapatkan hasil LED terjadinya TB Positif +I Pemeriksaan LED dengan rata-rata 55.71 mm/jam Dan Limfosit dengan rata-rata 48.51 %. TB Positif +II Pemeriksaan dengan rata-rata 63.33 mm/jam Dan Limfosit dengan rata-rata 61.16 %. Dan Hasil TB Positif +III Pemeriksaan dengan rata-rata 88.75 mm/jam Dan Limfosit dengan rata-rata 77 %Â Kata Kunci : Laju Endap Darah, TBC