bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term risk and predictors of cerebrovascular events following sepsis hospitalization: A systematic review and meta-analysis
Authors: Arero Amanuel Godana , Vasheghani-Farahani Ali , Tigabu Bereket Molla , Arero Godana , Ayene Beniyam Yimam , Soltani Danesh 
Published: November 2022

BackgroundLong-term risk and predictors of cerebrovascular events following sepsis hospitalization have not been clearly elucidated. We aim to determine the association between surviving sepsis hospitalization and cerebrovascular complications in adult sepsis survivors.MethodWe searched MEDLINE, Embase, Scopus, Web of Sciences, Cochrane library, and Google scholar for studies published from the inception of each database until 31 August 2022.ResultsOf 8,601 screened citations, 12 observational studies involving 829,506 participants were analyzed. Surviving sepsis hospitalization was associated with a significantly higher ischemic stroke [adjusted hazard ratio (aHR) 1.45 (95% CI, 1.23–1.71), I2 = 96], and hemorrhagic stroke [aHR 2.22 (95% CI, 1.11–4.42), I2 = 96] at maximum follow-up compared to non-sepsis hospital or population control. The increased risk was robust to several sensitivity analyses. Factors that were significantly associated with increased hazards of stroke were: advanced age, male gender, diabetes mellitus, hypertension, coronary artery disease, chronic heart failure, chronic kidney disease, chronic obstruction pulmonary disease, and new-onset atrial fibrillation. Only diabetes mellites [aHR 1.80 (95% CI, 1.12–2.91)], hypertension [aHR 2.2 (95% CI, 2.03–2.52)], coronary artery disease [HR 1.64 (95% CI, 1.49–1.80)], and new-onset atrial fibrillation [aHR 1.80 (95% CI, 1.42–2.28)], were associated with &gt; 50% increase in hazards.ConclusionOur findings showed a significant association between sepsis and a subsequent risk of cerebrovascular events. The risk of cerebrovascular events can be predicated by patient and sepsis-related baseline variables. New therapeutic strategies are needed for the high-risk patients.
Kinetic pupillary size using Pentacam in myopia
Authors: Li Kaixiu , Li Xiaoqi , Wang Qun , Wang Liqiang , Huang Yifei 
Published: November 2022

PurposeTo compare if the kinetic pupillary changes differs between high myopia (HM) and low/moderate myopia by Pentacam.SettingChinese People’s Liberation Army (PLA) General Hospital, Beijing, China.DesignComparative study.MethodsIn this cross-sectional retrospective study, 44 eyes of 44 patients were recruited in the Refractive Surgery Center of Chinese PLA General Hospital. Eyes were divided into two groups according to the refractive error: low/moderate myopia (22 eyes; −2.99 ± 1.09 D) and HM (22 eyes, −12.93 ± 3.44 D). At the beginning of the experiment, we made trials of scanning one false pupil by Pentacam. All patients underwent the Pentacam examination three times. Pupillary diameters (PD) during the scan process and other parameters were measured using the Pentacam. Coefficient variations of PD (CV) during the different scanning periods were analyzed comparatively between the two groups.ResultsPentacam once time output 25 Scheimpflug images, with 13 ones during the period from 1st to 1.5th s and 12 ones during the period from 2.5th to 3rd s after the scanning onset. For the spatial order on all the 25 meridians, 13 Scheimpflug images came out when the Pentacam rotated from 60° to 153°meridians and the remaining 12 Scheimpflug images from 161° to 245° meridians. Among pupillary parameters, no statistical significance existed in PD25, PD13, and PD12 (pupil diameter’s mean from all, former 13 and remaining 12 of 25 Scheimpflug images, respectively) (P &gt; 0.05) between the two groups. However, there were statistically significant differences in CV25 and CV13 (coefficient variation of the pupil diameters from all and former 13 of 25 images, respectively) (P &lt; 0.001), with no statistical significance in CV12 (coefficient variation of the pupil diameters from remaining 12 of 25 images) between both groups.ConclusionTwenty-five Scheimpflug images on Pentacam had the temporal and the spatial orders. CV in eyes with HM was lower than that in eyes with low/moderate myopia in a certain period of the Pentacam scan. Kinetic pupillary size in HM changed more slowly than that in low/moderate myopia during some scanning period analogous to the phasic response of the pupil reflex.
Mission-critical tasks for assessing risks from vestibular and sensorimotor adaptation during space exploration
Authors: Clément Gilles , Moudy Sarah C. , Macaulay Timothy R. , Bishop Michael O. , Wood Scott J. 
Published: November 2022

To properly assess the risk induced by vestibular and sensorimotor adaptation during exploration missions, we examined how long-duration stays on the International Space Station affect functional performance after gravity transitions. Mission-critical tasks that challenge the balance and the locomotion control systems were assessed: i.e., sit-to-stand, recovery-from-fall, tandem-walk, and walk-and-turn. We assessed 19 astronauts, including 7 first-time flyers and 12 experienced flyers, before their flight, a few hours after landing, and then 1 day and 6–11 days later. Results show that adaptation to long-term weightlessness causes deficits in functional performance immediately after landing that can last for up to 1 week. No differences were observed between first-time and experienced astronaut groups. These data suggest that additional sensorimotor-based countermeasures may be necessary to maintain functional performance at preflight levels when landing on planetary surfaces after a long period in weightlessness.
Surface electromyographic activity of the erector spinae and multifidus during arm- and leg-ergometer exercises in young healthy men
Authors: Shima Daichi , Nishimura Yukihide , Hashizaki Takamasa , Minoshima Yuta , Yoshikawa Tatsuya , Umemoto Yasunori , Kinoshita Tokio , Kouda Ken , Tajima Fumihiro , Kamijo Yoshi-Ichiro 
Published: November 2022

Objectives:Ergometer exercise was considered a new loading method that can be used for participants who are unable to assume the core strengthening exercise posture commonly used to strengthen the erector spinae and multifidus. This study aimed to investigate with healthy participants whether arm and leg ergometers could be used for core strengthening exercises and whether different exercise sites would affect the results.Methods:The study was conducted with 15 healthy adult male participants aged 20–35 years. The intervention consisted of arm- and leg-ergometer exercises performed by the participants. The exercise protocol consisted of three 1-min sessions (rest, 50W, and 100 W), which were measured consecutively. Surface electromyography (sEMG) was measured during the sessions. Maximal voluntary contraction (MVC) of the erector spinae and multifidus was also measured, during which sEMG was measured. The sEMG during ergometer exercise was calculated as a percentage of the MVC (calculated as % MVC). The root mean square (RMS) was recorded from the sEMG activity. Muscle activity of the erector spinae and multifidus was compared between ergometer exercises and between intensity levels. Heart rate (HR) was recorded by electrocardiogram.Results:In the arm-ergometer exercise, the % MVC values of the erector spinae were 6.3 ± 3.1, 10.9 ± 5.4, and 16.9 ± 8.3% at rest, 50 W, and 100 W conditions, respectively. The multifidus was 4.6 ± 2.9, 9.2 ± 5.6, and 12.6 ± 7.6% at rest, 50 W, and 100 W conditions, respectively. The respective % MVC values during the leg-ergometer exercise were 3.8 ± 1.7, 7.2 ± 3.8, and 10.4 ± 4.0% at rest, 50 W, and 100 W conditions, respectively. Leg-ergometer exercises were 2.6 ± 2.1, 6.9 ± 5.7, and 10.3 ± 6.8% at rest, 50 W, and 100 W conditions, respectively. The activities of the two muscles increased at comparable levels with increased workload in both types of exercises (p&lt; 0.01, each). HR increased with the increased workload and the increase was larger during arm-than leg-ergometer exercises.Conclusion:These results demonstrate that both arm- and leg-ergometer exercises are potentially alternative methods for erector spinae and multifidus training for healthy participants. Further research is needed to target elderly.
Comparative transcriptomic profiling of peach and nectarine cultivars reveals cultivar-specific responses to chilled postharvest storage
Authors: Muto Antonella , Bruno Leonardo , Madeo Maria Letizia , Ludlow Richard , Ferrari Michele , Stimpson Louise , LoGiudice Claudio , Picardi Ernesto , Ferrante Antonio , Pasti Luisa , Müller Carsten T. , Chiappetta Adriana Ada Ceverista , Rogers Hilary J. , Bitonti Maria Beatrice , Spadafora Natasha Damiana 
Published: November 2022

IntroductionPeach (Prunus persica (L.) Batsch,) and nectarine fruits (Prunus persica (L.) Batsch, var nectarine), are characterized by a rapid deterioration at room temperature. Therefore, cold storage is widely used to delay fruit post-harvest ripening and extend fruit commercial life. Physiological disorders, collectively known as chilling injury, can develop typically after 3 weeks of low-temperature storage and affect fruit quality.MethodsA comparative transcriptomic analysis was performed to identify regulatory pathways that develop before chilling injury symptoms are detectable using next generation sequencing on the fruits of two contrasting cultivars, one peach (Sagittaria) and one nectarine, (Big Top), over 14 days of postharvest cold storage.ResultsThere was a progressive increase in the number of differentially expressed genes between time points (DEGs) in both cultivars. More (1264) time point DEGs were identified in ‘Big Top’ compared to ‘Sagittaria’ (746 DEGs). Both cultivars showed a downregulation of pathways related to photosynthesis, and an upregulation of pathways related to amino sugars, nucleotide sugar metabolism and plant hormone signal transduction with ethylene pathways being most affected. Expression patterns of ethylene related genes (including biosynthesis, signaling and ERF transcription factors) correlated with genes involved in cell wall modification, membrane composition, pathogen and stress response, which are all involved later during storage in development of chilling injury.DiscussionOverall, the results show that common pathways are activated in the fruit of ‘Big Top’ nectarine and ‘Sagittaria’ peach in response to cold storage but include also differences that are cultivar-specific responses.
Exploring life with autism: Quality of Life, daily functioning and compensatory strategies from childhood to emerging adulthood: A qualitative study protocol
Authors: Øverland Elisabeth , Hauge Åshild Lappegard , Orm Stian , Pellicano Elizabeth , Øie Merete Glenne , Skogli Erik Winther , Andersen Per Normann 
Published: November 2022

IntroductionThis study aims to investigate self-perceived quality of life, daily functioning, and the use of compensatory strategies in emerging adults with autism1.Methods and analysisParticipants will be recruited from the Lillehammer Neurodevelopmental 10-year follow-up study (LINEUP), with the aim of 15 individual in-depth interviews. Subsequently, two focus groups with clinicians will be invited to reflect on the themes found in the individual interviews. All interviews will be recorded and analyzed using reflexive thematic analysis.Ethics and disseminationThe study is approved by the Regional Committee for Medical Research Ethics in South-East Norway. The findings will be disseminated to academic and clinical audiences through journal articles and conference presentations. To reach the broader autistic and autism communities, the findings will be shared with the Autism Society at national and local meetings, in their membership magazine, and on their social media channel.
Comparison of 10 obesity-related indices for predicting hypertension based on ROC analysis in Chinese adults
Authors: Lee Xiaohan , Gao Yanan , Zhang Yuting , Feng Yong , Gao Linna , Wang Aiwen , Jiang Yongbao , Huang Huiming 
Published: November 2022

ObjectiveTo compare the predictive performance of the percentage body fat (PBF), body mass index (BMI), waist circumference (WC), hip circumference (HC), waist–hip ratio (WHR), waist–height ratio (WHtR), a body shape index (ABSI), body roundness index (BRI), abdominal volume index (AVI), and conicity index (CI) for identifying hypertension.MethodsA cross-sectional study was conducted among 2,801 adults (1,499 men and 1,302 women) aged 18 to 81 in Ningbo, China. The receiver operator characteristic (ROC) analysis and multiple non-parametric Z tests were used to compare the areas under the curve (AUC). The maximum Youden's indices were used to determine the optimal cut-off points of 10 obesity-related indices (ORI) for hypertension risk.ResultsThe AUC of all the indices were statistically significant (P &lt; 0.05). The AUC of all the indices in men and women were 0.67–0.73 and 0.72–0.79, respectively. Further non-parametric Z tests showed that WHR had the highest AUC values in both men [0.73 (95% CI: 0.70, 0.76)] and women (0.79 (95% CI: 0.75, 0.83)], and several central ORI (men: WHR, WC, BRI, AVI, and CI, 0.71–0.73; women: WC, WHR, and AVI, 0.77–0.79) were higher than general ORI (PBF and BMI, 0.68 in men; 0.72–0.75 in women), with adjusted P &lt; 0.05. The optimal cut-off points for identifying hypertension in men and women were as follows: PBF (23.55%, 32.55%), BMI (25.72 kg/m2, 23.46 kg/m2), HC (97.59 cm, 94.82 cm), WC (90.26 cm, 82.78 cm), WHR (0.91, 0.88), WHtR (0.51, 0.55), ABSI (0.08 m7/6/kg2/3, 0.08 m7/6/kg2/3), BRI (4.05, 4.32), AVI (16.31 cm2, 13.83 cm2), and CI (1.23 m2/3/kg1/2, 1.27 m2/3/kg1/2). Multivariate logistic regression models showed that all indices were statistically significant (P &lt; 0.05) with the adjusted ORs (per 1-SD increase) at 1.39–2.06 and ORs (over the optimal cut-off points) at 1.80–2.64.ConclusionsAll 10 ORI (PBF, BMI, HC, WC, WHR, WHtR, ABSI, BRI, AVI, and CI) can effectively predict hypertension, among which WHR should be recommended as the best predictor. Central ORI (WHR, WC, and AVI) had a better predictive performance than general ORIs (PBF and BMI) when predicting the risk of hypertension.
The impact of COVID-19 and access to health services in the Hispanic/Mexican population living in the United States
Authors: Rangel Gómez María Gudelia , Alcocer Varela Jorge , Salazar Jiménez Saúl , Olivares Marín Leonardo , Rosales Cecilia 
Published: November 2022

IntroductionThe United States is home to 10.5 million undocumented immigrants, of which 5 out of 10 are Mexican or Central American. Their immigration status is an obstacle to secure employment that provides labor benefits such as sick leave and health insurance. Living through the global pandemic in the U.S. had a negative impact on this vulnerable population's mental and physical health. They avoided seeking primary or hospital care fearful that they were undocumented and uninsured. The services provided by the Ventanillas de Salud (VDS) “Health Windows” mitigated this pandemic's negative impact and have become an important source to support and increase access to health services among the immigrant community.MethodsDe-identified data from a database system called the Continuous Information System and Health Reports of Mexicans in the United States (SICRESAL-MX) to perform this secondary analysis. The descriptive analysis describes socio-demographic, epidemiological, and situational characteristics of COVID-19.ResultsBetween January 2020 and July 2021, the VDS and UMS provided 11.5 million individual services to just over 4.3 million people. The main health conditions are overweight and obesity, high blood pressure and elevated cholesterol and glucose levels. Between March 2020 to July 2021 a total of 2,481,834 specific services related to COVID-19 were offered.DiscussionThe Mexican migrant community in the United States is in a vulnerable situation, largely due to its immigration status which limits their access to health and human services, including primary health care services. Many of them have suffered from chronic diseases since before the pandemic, generating difficulties in monitoring the ailments and exacerbating their conditions.
Evidence of Resistance to QoI Fungicides in Contemporary Populations of Mycosphaerella fijiensis, M. musicola and M. thailandica from Banana Plantations in Southeastern Brazil
Authors: Oliveira Tamiris Y. K. , Silva Tatiane C. , Moreira Silvino I. , Christiano Felix S. , Gasparoto Maria C. G. , Fraaije Bart A. , Ceresini Paulo C. 
Published: November 2022

Yellow and black Sigatoka, caused by Mycosphaerella fijiensis and M. musicola, respectively, are the most important worldwide foliar diseases of bananas. Disease control is heavily dependent on intensive fungicide sprays, which increase selection pressure for fungicide resistance in pathogen populations. The primary objective of this study was to assess the level and spread of resistance to quinone-outside inhibitors (QoI—strobilurin) fungicides in populations of both pathogens sampled from banana fields under different fungicide spray regimes in Southeastern Brazil. Secondly, we aimed to investigate when QoI resistance was confirmed if this was associated with the target-site alteration G143A caused by a mutation in the mitochondrial encoded cytochrome b gene. QoI resistance was detected in fungicide treated banana fields, while no resistance was detected in the organic banana field. A total of 18.5% of the isolates sampled from the pathogens’ populations were resistant to QoI. The newly described M. thailandica was also found. It was the second most abundant Mycosphaerella species associated with Sigatoka-like leaf spot symptoms in the Ribeira Valley and the highest level of QoI resistance was found for this pathogen. The G143A cytochrome b alteration was associated with the resistance to the QoI fungicides azoxystrobin and trifloxystrobin in M. fijiensis, M. musicola and M. thailandica strains. In order to reduce resistance development and maintain the efficacy of QoI fungicides, anti-resistance management strategies based on integrated disease management practices should be implemented to control the Sigatoka disease complex.
Análise dos casos de COVID-19 em uma cidade no sertão da Paraíba
Authors: De Melo Andrea Calyane Neves Ferreira , Saraiva Gisele Sampaio , Alencar Mifran Cabral , Pereira Wanderson de Almeida , Figueiredo Ariagnes Queiroz , De Souza Filho João Bosco , Albano Ana Caroline Pires Braga , Sales Mariana Almeida 
Published: November 2022

Trata-se de uma análise epidemiológica sobre as notificações de síndrome gripal (SG) com o SARS-CoV-2 como agente etiológico em uma cidade do sertão da Paraíba, tomando base o início das notificações no e-SUS Notifica, em março de 2020, até a última semana epidemiológica de 2021. Tem por objetivo analisar o perfil dos casos de COVID-19, registrados, o que ajuda a entender o comportamento da pandemia ao longo do tempo, bem como observar a efetividade da vacinação. A partir desta pesquisa, constatou-se que a cidade de Pombal-PB teve 5.023 notificações de casos de SG, mas apenas 2.201 se enquadraram nos critérios para análise. Destes, 46,5% eram do sexo masculino e 53,5% do sexo feminino. As informações coletadas também demostraram uma discrepância entre esses dados e os disponíveis pelo governo do Estado da Paraíba, tanto pelo fato do Estado ter acesso a outros sistemas de coleta de informações, como por faltas durante os registros no sistema. Além disso, observou-se que as manifestações clínicas mais descritas foram dor de garganta (35,8%, N=853), tosse (34,9%, N= 768) e febre (34,3%, N= 754), o que divergiu da literatura encontrada. Entretanto, este estudo ainda é falho devido à subnotificação dos casos, de forma que não se tem como afirmar a confiabilidade da informação. Dessa forma, sugerimos que estratégias amplas sejam implementadas para fechamento dos casos em aberto no sistema, além de capacitação dos profissionais responsáveis pela digitalização de tais registros, para que, no futuro, tenhamos dados públicos mais fidedignos com a realidade.
IMPLEMENTASI PENGENDALIAN KUALITAS PENCETAKAN KORAN HARIAN DENGAN METODE SIX SIGMA (STUDI KASUS : PT. ARNOLDUS NUSA INDAH DI KABUPATEN ENDE, NUSA TENGGARA TIMUR)
Authors: Tibo Apolonia Bunga , Atti Astri , Lobo Maria , Kleden Maria 
Published: November 2022

Pengendalian kualitas produk merupakan faktor penting bagi dunia industri agar dapat meningkatkan kualitas produk dan dapat bersaing dengan baik. PT. Arnoldus Nusa Indah (PT. ANI) adalah salah satu perusahaan percetakan yang sedang berusaha meningkatkan kualitas pada proses produksinya. Tujuan dari penelitian adalah untuk mengetahui proses pengendalian kualitas yang diterapkan PT. ANI dalam produksi koran harian Flores Pos menggunakan metode Six Sigma. Six Sigma merupakan suatu metode pengendalian dan peningkatan kualitas yang hanya memproduksi 3,4 kegagalan per sejuta kesempatan untuk setiap produk yang dihasilkan. Setelah menggunakan metode Six Sigma kualitas produk yang dihasilkan PT. ANI cukup baik dengan tingkat sigma sebesar 3,69 dengan kegagalan sebesar 14.171 eksemplar untuk sejuta produksi. Dari hasil penelitian dapat disimpulkan tinta menyebar tidak merata (68,8%) dan kertas menjadi kusut atau lipatan tidak sempurna (31,2%) adalah penyebab terjadinya cacat tertinggi.
PELABELAN P_2⊳F_n AJAIB SUPER DARI GRAF S_m⊳F_n
Authors: Putra Ganesha Lapenangga , Simanungkalit Erika Feronika 
Published: November 2022

Graf didefinisikan sebagai pasangan terurut himpunan titik dan sisi, dinotasikan dengan . Misalkan dan suatu graf. Hasil kali sisir antara graf dan , dinotasikan dengan , yaitu graf yang diperoleh dengan mengambil satu salinan graf dan salinan sebanyak dari graf dan mengidentifikasikan salinan ke- dari graf ke titik ke- pada graf . Misalkan suatu graf terhubung yang memuat selimut- . Suatu pelabelan -ajaib dari graf adalah suatu fungsi bijektif , sehingga , untuk semua subgraf yang isomorfik dengan dengan suatu konstanta. Selanjutnya, graf disebut -ajaib super jika . Pada jurnal ini, diberikan pelabelan ajaib super dari graf dengan metode multi himpunan seimbang.
Analisis Tingkat Kepuasan Mahasiswa Terhadap Proses Pembelajaran Dan Kualitas Layanan Akademik Masa Pandemi Covid-19
Authors: Pangaribuan Rapmaida Megawaty , Ginting Keristina Br 
Published: November 2022

Kegiatan pembelajaran dan layanan akademik secara dalam jaringan (daring) menjadi pilihan yang tepat di masa Pandemi Covid-19. Keberhasilan pelaksanaan aktivitas dalam jaringan dikatakan berjalan dengan baik, salah satunya dapat dapat dilihat dari tingkat kepuasan penerima layanan . Tetapi berdasarkan hasil pengamatan peneliti ditemukan keluhan-keluhan yang menujukkan ketidakpuasan terhadap layanan proses pembelajaran dan layanan akademik yang dilakukan secara daring. Tujuan dari penelitian ini adalah untuk melihat tingkat kepuasan mahasiswa Fakultas Sains dan Teknik Universitas Nusa Cendana terhadap proses pembelajaran dan layanan akademik dengan menggunakan istrumen angket model skala likert. Ada lima indikator yang digunakan dalam penelitian ini, yaitu: tangibles (alat perkuliahan, media pembelajaran dan prasarana pendidikan), reliability (keandalan dosen dan staf akademik), responsiveness (sikap tanggap), assurance (jaminan kepastian) dan emphaty. (empati) Hasil analisis data statistika menunjukkan bahwa secara umum mahasiswa Fakultas Sains dan Teknik Universitas Nusa Cendana puas terhadap layanan proses pembelajaran dan layanan akademik dengan nilai skor rata-rata pilihan mahasiswa 3,78 dan persen rata-rata tingkat capaian responden (TCR) adalah 75,65%. Jika dianalisis secara per item terdapat 2 item yang sudah berada dalam kategori sangat memuaskan dan masih terdapat 5 item berada pada kategori cukup memuaskan, sehingga untuk item yang masih berada dalam kategori cukup memuaskan masih sangat perlu untuk ditingkatkan.