bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular Managent of Supra and Infra Tentorial Pediatric Intracranial Aneurysms: A Single Center Experience
Authors: PURKAYASTHA SUKALYAN , NATH ABIR LAL , MOHAMMAD ABDULLAH AL MUZAHID , PELLURU PAVANKUMAR 
Published: September 2022

Abstract
Intracranial aneurysms are rare in pediatric population. They have different pathophysiology, location, type, outcome than adults. Long life expectancy, denovo occurrence and their tendency to recur necessitate the long term follow up in these cases. Here we summarize our experience in treating these aneurysms in a tertiary care hospital from 2014 to 2021. We found 4% of our total aneurysm population to be under 18 years with a male to female ratio of 1.5:1. 13.3% patients had multiple aneurysms and 38.9% had posterior circulation aneurysms. Most common site of aneurysm was ICA bifurcation. Most of the patients were treated endovascularly with favorable outcome at follow up.
Global research trends in petrochemical wastewater treatment from 2000 to 2021
Authors: Kalantari Mahdi , Moghaddam Shabnam Sadri , Vafaei Fereidon 
Published: September 2022

Abstract
Petrochemical wastewater (PWW) is a huge industrial contaminant that generates a wide range of resistive and poisonous organic pollutants that harm animals and plants in natural water bodies when discharged untreated or partially treated. Therefore, it is vital to develop technologies that are simple, efficient, and profitable for the treatment of oily wastewater. Although, much study has been undertaken on the treatment of PWW, there hasn't been any recent work on bibliometrics analysis of global research trends on this issue. A bibliometric analysis will help current and future researchers figure out where the gaps are and how to fill them. The present study's focus is to examine the characteristics and trends of research on oily wastewater treatment with an emphasis on the treatment of PWW. This research was performed on five important aspects, including characterization of research publications; countries' performances and collaborations; an analysis of the best papers with the most citations; keyword analysis (including frequency distribution of the keyword analysis; the transformation of the keyword combination across time; and exploration of changes in rank over time); and journal analysis, according to the 2457 papers in the Science Citation Index Expanded using the Web of Science (WoS) database from 2000 to 2021. For further analysis, the contingency matrix, bump diagram, and inter-temporal network stream were employed.
A Beta-containing bivalent SARS-CoV-2 spike protein vaccine candidate with AS03 elicits durable and broad neutralization of variants including Omicron in macaques and confers protection in hamsters
Authors: Berry Catherine , Pavot Vincent , Anosova Natalie , Kishko Michael , Huang Dean , Tibbitts Tim , Raillard Alice , Gautheron Sylviane , Cummings Sheila , Bangari Dinesh , Kar Swagata , Atyeo Caroline , Deng Yixiang , Alter Galit , Gutzeit Cindy , Koutsoukos Marguerite , Chicz Roman , Lecouturier Valerie 
Published: September 2022

Abstract
Background Since the beginning of the COVID-19 pandemic, several variants of concern (VOC) have emerged for which there is evidence of an increase in transmissibility, more severe disease, and/or reduced vaccine effectiveness. Effective COVID-19 vaccine strategies are required to achieve broad protective immunity against current and future VOC.Methods We conducted immunogenicity and challenge studies in macaques and hamsters using a bivalent recombinant vaccine formulation containing the SARS-CoV-2 prefusion-stabilized Spike trimers of the parental D614 and the Beta (B.1.351) strains with AS03 adjuvant (CoV2 preS dTM-AS03) in a primary immunization setting. Results We show that a primary immunization with the bivalent CoV2 preS dTM-AS03 elicits broader and durable neutralizing antibody responses against VOC including Omicron BA.1, and SARS-CoV-1 as compared to the parental D614 or Beta variant monovalent vaccines in naïve non-human primates. In addition, the bivalent formulation confers protection against viral challenge with SARS-CoV-2 parental D614G strain as well as Alpha and Beta variant strains in hamsters. Conclusions Our findings demonstrate the potential of a Beta-containing bivalent CoV2 preS dTM-AS03 formulation to provide broad and stable immunogenicity, as well as protection against VOC in naïve populations.
Assessing the size and uncertainty of remaining carbon budgets
Authors: Lamboll Robin , Nicholls Zebedee , Smith Christopher , Kikstra Jarmo , Byers Edward , Rogelj Joeri 
Published: September 2022

Abstract
The remaining carbon budget (RCB), the net amount of carbon dioxide humans can still emit without exceeding a chosen global warming limit, is often used to evaluate political action against the goals of the Paris Agreement. RCB estimates for 1.5C are small, and minor changes in their calculation can therefore result in large relative shifts. Here we evaluate recent RCB assessments by the IPCC and explain differences between them. We present calculation refinements together with robustness checks that increase confidence in RCB estimates. We conclude that the RCB for a 50% chance of keeping warming to 1.5C is around 300 GtCO2 as of January 2022, less than 8 years of current emissions. This estimate changes to 530 and 110 GtCO2 for a 33% and 66% chance, respectively. Key uncertainties affecting RCB estimates are the contribution of non-CO2 emissions, which depends on socioeconomic projections as much as on geophysical uncertainty, and the potential warming after net zero is reached.
Design of a High Efficiency Cross-Domain Medical Image Retrieval System Using Augmented Transfer Learning
Authors: Ahmed Syed Tanzeem , Zuber Mohd , Aamer Najmuddin 
Published: September 2022

Abstract
Retrieving Medical Images from a large inter-domain dataset requires multiple high efficiency processing models. These models include, but are not limited to, image classification, domain specific feature extraction & selection, ranking and post processing. A wide variety of system models have been designed to perform these tasks, but have limited accuracy, and retrieval performance due to improper cross-domain feature processing. In order to improve performance of cross-domain medical image retrieval systems, this text proposes a transfer learning mechanism, that learns from features of one domain, and applies the trained models to other domains. The proposed method uses a combination of VGGNet19, AlexNet, InceptionNet and Xception Net models for ensemble learning, along with wavelet and bag of features (WBoF) for efficient feature extraction. Each of the individual models were applied to different medical domains, and their retrieval accuracies were evaluated. Based on this evaluation, it is observed that VGGNet19 has better performance on Computer Tomography (CT) images, AlexNet model has better performance on Magnetic Resonance Imaging (MRI) images, InceptionNet model has better performance on Positron Emission Tomography (PET) images, while Xception Net has better retrieval performance for ultrasound (USG) images. Using this observation, a highly efficient augmentation model is designed, which achieves an accuracy of 98.06%, precision of 65.9%, recall of 76.1%, and area under the curve (AUC) performance of 98.9% on different datasets. This performance is compared with a wide variety of medical image datasets including Center for Invivo Microscopy (CIVM), Embrionic and Neonatal Mouse (H&E, MR), LONI image data archive, The Open Access Series of Imaging Studies (OASIS), & CT scans for Colon Cancer (CSCC). It was observed that the proposed model outperforms most of the recent state-of-the-art models, and achieves consistent parametric results across multiple domain medical images.Categories: H.3.1, H.3.2, H.3.3, H.3.7, H.5.1
4.5SH RNA counteracts deleterious exonization of SINE B1 in mice
Authors: Nakagawa Shinichi , Yoshimoto Rei , Nakayama Yuta , Yamamoto Ikuko , Tanaka Shigeyuki , Kurihara Misuzu , Suzuki Yu , Kobayashi Takehiko , Kozuka-Hata Hiroko , Oyama Masaaki , Mito Mari , Iwasaki Shintaro , Yamazaki Tomohiro , Hirose Tetsuro , Araki Kimi 
Published: September 2022

Abstract
A huge number of noncoding RNAs are transcribed from the genomes of higher eukaryotes, many of which are species-specific and localize in the nucleus with unknown function. 4.5SH RNA is a highly abundant, small rodent-specific noncoding RNA that localizes to nuclear speckles enriched in pre-mRNA splicing regulators. Here we show that mutant mice lacking the expression of 4.5SH RNA are embryonic lethal, suggesting that 4.5SH is an essential species-specific gene in mice. RNA-sequencing analyses revealed that 4.5SH RNA protects transcriptome from abnormal exonizations of the antisense insertions of retrotransposon SINE B1 (asB1), which would otherwise introduce deleterious premature stop codons or frameshift mutations. Mechanistically, 4.5SH RNA base-pairs with complementary asB1-containing exons and recruits effector proteins via its 5' stem loop. The modular organization of 4.5SH RNA enables us to engineer a programmable splicing regulator to induce the skipping of target exon of interest.
Quantitative Structure Activity Relationship and Molecular Docking Studies on A Series of Thiourea and Thiazolidine-4-Carboxylic Acid Analogues as Potent Neuraminidase Inhibitors.
Authors: Abha Abha Shrivastava , Manish Manish Rao Ambedkar , Basheerulla Basheerulla Shaik , Vijay Vijay k Agrawal 
Published: September 2022

Abstract
Neuraminidase inhibitors are a type of medication that inhibits the neuraminidase enzyme. They are type of antiviral medication that is often used to treat influenza. In this paper we have taken 53 Compounds which are derivatives of Thiourea and Thiazolidine-4-Carboxylic acid derivatives. We modelled the pIC50 activity using RDF115p, E2s, R1i Parameters. The excellent value of r2 = 0.725 Shows that following model is best suitable. We also Performed docking study and the best docking score is -28.1891, and the best predicted activity is 8.36.
High incidence of acetabular retroversion in gluteal muscle contracture patients based on X-ray film
Authors: Zhao Yikun , Dong Xueping , Zhang Mengdi , Zhao Zhen , Zhang Xintao 
Published: September 2022

Abstract
Objective
In the clinic, gluteus muscle contracture (GMC) is found to cause pelvic structural changes, including acetabular retroversion (AR). However, its incidence has not been reported. This study aimed to explore the anteroposterior pelvic radiographs of GMC patients to identify the prevalence of AR.
Methods
The imaging characteristics of anteroposterior pelvic radiographs on 100 cases of GMC and 100 healthy people were analyzed. GMC was diagnosed by ‘iliac hyperdense line’(IHDL), while ‘prominence of the ischial spine’ (PRIS) or cross-over sign’ (COS) were used to define AR.
Results
‘iliac hyperdense line’ was only observed in GMC patients (92%). There were 80 cases that showed PRIS in the GMC group, but only 19 in the control group. Similarly, the incidence of COS was 76% in patients and 5% in normal people. All the differences between the two groups of these indicators were statistically significant (P < 0.001). Furthermore, a statistical correlation was confirmed between PRIS and COS when they were positive in GMC patients.
Conclusion
AR showed a high incidence in patients with GMC based on PRIS and COS.
Relationship between myocardial microcirculation perfusion and myocardial mechanics in nonobstructive hypertrophic cardiomyopathy at rest
Authors: Nan Jing , Guan Lina , Yuan Chao , Ba Ya , Mu Yuming 
Published: September 2022

Abstract
Objective
To quantitatively analyze myocardial microcirculation perfusion in nonobstructive hypertrophic cardiomyopathy (HCM) patients, evaluate myocardial mechanics characteristics in nonobstructive HCM and explore the relationship between microcirculation perfusion and myocardial mechanics in nonobstructive HCM patients.
Methods
Twenty-eight healthy volunteers and twenty-eight nonobstructive HCM patients were recruited as the case group. All subjects underwent two-dimensional echocardiography, contrast-enhanced myocardial ultrasound (MCE), and two-dimensional speckle tracking imaging (2D-STI).The nonobstructive HCM patients were divided into a hypertrophic segmental myocardium (HS) group and a nonhypertrophic segmental myocardium (NHS) group according to the degree of myocardial hypertrophy.
Results
(1) There were no statistically significant differences in age, height, weight, body surface area, systolic blood pressure, diastolic blood pressure, or heart rate between the nonobstructive HCM and control groups (P > 0.05). Myocardial thickness (MT), tricuspid regurgitation (TR), E/e', the left atrial volume (LAV) and the left atrial volume index (LAVI) increased in the nonobstructive HCM group, while stroke volume (SV), end-diastolic volume (EDV), end-systolic volume (ESV) and E/A decreased, and the differences were statistically significant (P < 0.05). (2) Compared with those in the control group, peak intensity (PI) and area under the curve (AUC) in the nonobstructive HCM group decreased, s-RS, s-PI, s-TTP and s-AUC in the HS group decreased, and s-PI and s-AUC in the NHS group decreased. The differences were statistically significant (P < 0.05). (3) The nonobstructive HCM group showed a significant decrease in GLS compared with the control group (P < 0.05), although the change in GCS was not significant (P > 0.05), and GLS and GCS were not significantly different between the HS and NHS groups (P > 0.05). (4) In the HS group, PI, AUC, s-PI, s-AUC and GLS were positively correlated, s-TTP was negatively correlated with GLS and GCS (P < 0.05), and RS and s-RS had no correlation with GLS and GCS.
Conclusion
In nonobstructive HCM patients, myocardial microcirculation perfusion and longitudinal strain of the myocardium were impaired in both hypertrophic and nonhypertrophic segmental myocardium. Hypertrophic myocardial segments in nonobstructive HCM patients have more significant damage and close correlations with changes in myocardial mechanics.
Simultaneous Multislice Acquisition for Accelerated Readout-segmented DTI in Diabetic Peripheral Neuropathy
Authors: Yin Cuilin , Ran Jun , Xie Ruyi , Morelli John N , Li Yitong , Hou Bowen , Wu Gang , Xiaoming Li 
Published: September 2022

Abstract
Simultaneous Multislice Acquisition for Accelerated Readout-segmented DTI in Diabetic Peripheral Neuropathy.
To explore the feasibility of using a simultaneous multislice (SMS) acquisition to accelerate readout-segmented diffusion tensor imaging (DTI) for visualization and quantitative evaluation of the tibial nerve (TN) and common peroneal nerve (CPN) and to assess the diagnostic accuracy of accelerated DTI in diabetic peripheral neuropathy (DPN). Fifteen DPN patients and forty healthy volunteers were enrolled and underwent non-SMS and SMS-accelerated readout-segmented DTI. Two radiologists independently measured the DTI parameters of TN and CPN. We compared the differences between non-SMS and SMS-accelerated DTI and assessed the differences in the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of TN and CPN between DPN patients and healthy volunteers. Wilcoxon rank sum test was used to compare the differences in subjective scores of image quality between the two sequences. The diagnostic efficacy of DTI parameters for DPN was evaluated using a receiver operating characteristic curve (ROC).
SMS-accelerated readout-segmented DTI has similar imaging capability as non-SMS DTI, but greatly reduces the scan time, thus making it a potentially effective non-invasive modality for the diagnosis of DPN.
Global, Regional, national Burden and Gender Disparity of Cataract: Findings From the Global Burden of Disease Study 2019
Authors: Fang Rui , Lv Ning-Xin , Yu Yang-Fan , Li En-Jie , Liu Zhao-Chuan , Zhou Hong-Gang , Song Xu-Dong 
Published: September 2022

Abstract
Background: To evaluate the global burden of cataracts by year, age, region, gender, and socioeconomic status using disability-adjusted life years (DALYs) and prevalence from the Global Burden of Disease (GBD) study 2019. Methods: Global, regional, or national DALY numbers, crude DALY rates, and age-standardized DALY rates caused by cataracts, by year, age, and gender, were obtained from the Global Burden of Disease Study 2019. Socio-demographic Index (SDI) as a comprehensive indicator of the national or regional development status of GBD countries in 2019 was obtained from the GBD official website. Kruskal-Wallis test, linear regression, and Pearson correlation analysis were performed to explore the associations between the health burden with socioeconomic levels, Wilcoxon Signed-Rank Test was used to investigate the gender disparity. Results: From 1990 to 2019, global DALY numbers caused by cataracts rose by 91.2%, crude rates increased by 32.2%, while age-standardized rates fell by 11.0%. Globally, age-standardized prevalence and DALYs rates of cataracts peaked in 2017 and 2000, with the prevalence rate of 1283.53 [95% uncertainty interval (UI) 1134.46–1442.93] and DALYs rate of 94.52 (95% UI 67.09– 127.24) per 100000 population, respectively. The burden was expected to decrease to 1232.33 (95% UI 942.33–1522.33) and 91.52 (95% UI 87.11–95.94) by 2050. Southeast Asia had the highest blindness rate caused by cataracts in terms of age-standardized DALY rates (99.87, 95% UI: 67.18–144.25) in 2019. Gender disparity has existed since 1990, with the female being more heavily impacted. This pattern remained with aging among different stages of vision impairments and varied through GBD super regions. Gender difference (females minus males) of age-standardized DALYs (equation: Y=-53.2*X + 50.0,P<0.001) and prevalence rates (equation: Y = -492.8*X + 521.6,P<0.001) was negatively correlated with SDI in linear regression. Conclusion: The global health of cataracts is improving but the steady growth in crude DALY rates suggested that health progress does not mean fewer demands for cataracts. Globally, older age, females, and lower socioeconomic status are associated with higher cataract burden. The findings of this study highlight the importance to make gender-sensitive health policies to manage global vision loss caused by cataracts, especially in low SDI regions.
Assessment of the distribution and ecological risks of heavy metals in coastal sediments in Vietnam’s Mong Cai area
Authors: Bui Thi Thanh Loan , Dang Hoai Nhon , Nguyen Dac Ve , Nguyen Thi Mai Luu , Le Nhu Sieu , Nguyen Thi Hue , Bui Van Vuong , Duong Thanh Nghi , Le Van Nam , Pham Tien Dung , Vo Thi Anh , Ha Lan Anh , Nguyen Thi Kim Dung , Nguyen Manh Ha , Nguyen Van Chien , Nguyen Thi Huong Lan 
Published: September 2022

Abstract
The Mong Cai area, coastal sediments were collected and analyzed for grain sizes, heavy metals, total organic carbon, and isotopes (210Pb, 226Ra, δ15N, δ13C) for assessing sediment quality.Which sediments common were fine sand in surface sediment, very fine sand in core C1, very coarse silt and coarse silt in core C2. The total organic carbon was highest in C2 next to the surface and lowest in C1, with content levels of 1.81%, 0.40%, and 0.31%, respectively. δ13C and δ15N in the sediment reflected the source of the organic matter mix from the marine and terrigenous sediments. Heavy metals were lower than ISQGs, exception of As in C1 and C2 were higher, in C1 showed a decline over time, while in C2 increased between 1996 and 2019. The Mong Cai area was common by sand, accumulation of heavy metals was small, impact of heavy metal pollution on ecosystems was low.
Community structure of saproxylic arthropods along an urbanization gradient
Authors: Miyazaki Satoshi , Koike Fumito 
Published: September 2022

Abstract
Saproxylic arthropods play essential roles in the detritus food chains of forest ecosystems by contributing to wood decomposition and nutrient cycling. Here, we examined saproxylic arthropod communities along a gradient from large forests to urban fragmented forests to clarify the effects of urbanization on the structure and composition of these communities. We found that communities could be allocated to three groups on the basis of species composition, and the groups were correlated with the urbanization gradient represented by forest size. The fragmented urban forest community had large numbers of individuals of few facultative saproxylic species, whereas many obligate saproxylic species—proportional to the abundant dead wood volume— occurred in the large forest community. As result, species richness was significantly lower in communities in fragmented urban forests than in those in large forested areas, as determined by using rarefaction curves based on the number of individuals. However, this difference was not significant when the curve was based on wood volume. Implications for insect conservationOur result suggested that forest size as urbanization scale was the most important environmental factor influencing the saproxylic arthropod communities because species composition and species diversity were affected by forest area. We need to protect large forests to conserve the overall diversity of saproxylic arthropods.
Development and Validation of Stability Indicating HPTLC Method for Simultaneous Estimation of Metformin Hydrochloride and Remogliflozin Enabonate in Pharmaceutical Dosage Form
Authors: Jaiswal Reema , Kohad Mitun , Michael Patelia Emanual , RAVAL HITESH 
Published: September 2022

Abstract
A novel and quick HPTLC-densitometric method was developed for the simultaneous determination of Metformin Hydrochloride and Remogliflozin Enabonate. Chromatographic separation of the drugs was performed on precoated silica gel aluminium plate 60F254, (20×10) 100µm thickness; using Methanol: Ethyl Acetate: Acetic Acid (6:3.5:0.5v/v) as mobile phase. A TLC scanner set at 245 nm was used. The two drugs were satisfactorily resolved with Rf values Rf 0.23 for MET and Rf 0.83 for REMO respectively. Calibration curves were polynomial in the range concentration range of 200-1200ng/band for Remogliflozin Enabonate and 1000-6000ng/band for Metformin Hydrochloride. Correlation coefficients (r) values were 0.9999, 0.9999,for Metformin Hydrochloride and Remogliflozin Enabonate respectively. A low relative standard deviation (< 2%) was found for both precision and robustness study showing that the proposed method was precise and robust. The method had an accuracy of 98.82%, 98.42% of Metformine Hydrochloride and Remogliflozin Enabonate were validated according to ICH guidelines. The percentage recovery ranges from 98–101%. Forced degradation conditions of hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress, as suggested in the ICH guideline Q1A (R2).