bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis
Authors: Alshehri Mansour Abdullah , van den Hoorn Wolbert , Klyne David M. , Hodges Paul W. 
Published: May 2022

Introduction
Postural control of the trunk is critical for performance of everyday activities and the health of spinal tissues. Although some studies report that individuals with low back pain (LBP) have poorer/compromised postural control than pain-free individuals when sitting on an unstable surface, others do not. Analyses commonly lack the statistical power to evaluate the relevance of features that could impact the performance of postural control, such as sex, age, anthropometrics, pain intensity or disability. This paper outlines a protocol for a systematic review with an individual participant data (IPD) meta-analysis that aims to synthesise the evidence and evaluate differences of postural control measures between individuals with and without LBP during unstable sitting.

Methods and analysis
A systematic review with IPD meta-analysis will be conducted according to PRISMA-IPD guidelines. To identify relevant studies, electronic databases and the reference lists of included articles will be screened. Unstable seat movements are derived from centre of pressure (CoP) data using a force plate or angle of the seat using motion systems/sensors. The comprehensiveness of reporting and methodological quality of included studies will be assessed. Analysis will involve a descriptive analysis to synthesise the findings of all included studies and a quantitative synthesis using two-stage IPD meta-analysis of studies that include both individuals with and without LBP for which IPD set can be obtained from authors. Analyses will include consideration of confounding variables.

Ethics
Exemption from ethical approval was obtained for this review (University of Queensland, ID: 2019003026).

Systematic review registration
PROSPERO ID: CRD42021124658.
Can 17 hydroxyprogesterone caproate (17P) decrease preterm deliveries in patients with a history of PMC or pPROM?
Authors: Cohen Gal , Shavit Maya , Miller Netanella , Moran Rimon , Yagur Yael , Weitzner Omer , Ovadia Michal , Schreiber Hanoch , Shechter-Maor Gil , Biron-Shental Tal 
Published: May 2022

Background
A history of spontaneous preterm birth (sPTB) is a significant risk factor for recurrence. Intra-muscular-7α-hydroxyprogesterone caproate (17P) has been the preventive treatment of choice until the recent “Prolong study” that reported no benefit.

Objective
To determine the benefit of (17P) treatment in preventing reoccurrence of sPTB, by evaluating two presenting symptoms of the first sPTB: premature contractions (PMC) and preterm premature rupture of membranes (pPROM).

Study design
This retrospective study included 342 women with a previous singleton sPTB followed by a subsequent pregnancy. sPTB were either due to PMC (n = 145) or pPROM (n = 197). During the subsequent pregnancy, 90 (26.3%) patients received 250 mg 17P IM. Each presenting symptom–PMC or pPROM–was evaluated within itself comparing treated vs. untreated groups. Data were analyzed using t-test, Chi-square and Fisher’s exact test. Logistic regression analysis was also performed.

Results
Patients treated with 17P in the subsequent pregnancy had delivered earlier in the previous pregnancy (33.4w vs. 35.3w in the PMC group, and 34.1w vs. 35.7w in the pPROM group, p<0.001). In the following pregnancy, they had higher admission rates due to suspected preterm labor (31.7% vs. 10.9% in the treated vs. untreated PMC group (p = 0.003) and 26.1% vs. 5.4% in the treated vs. untreated pPROM group (p<0.001). In both groups, but more prominently in the previous PMC group, treatment compared to non-treatment in the subsequent pregnancy significantly prolonged it (4.3w vs. 2.6w in the PMC group (p = 0.007), and 3.7w vs. 2.7w in the pPROM group (p = 0.018)).
The presenting symptom of sPTB in the following pregnancy tended to recur in cases of another sPTB, with a significantly greater likelihood of repeating the sPTB mechanism in cases with PMC, regardless of receiving 17P (69% in the PMC cohort and 60% in the pPROM cohort, p<0.001).

Conclusions
17P might delay preterm delivery in patients with a previous sPTB on an individual level (prolongation of the pregnancy for each patient compared to her previous delivery). Therefore, our results imply that 17P can decrease potential premature delivery complications for patients with a previous sPTB due to PMC or pPROM.
A comparison of attitudes and knowledge of pre-exposure prophylaxis (PrEP) between hospital and Key Population Led Health Service providers: Lessons for Thailand’s Universal Health Coverage implementation
Authors: Rayanakorn Ajaree , Chautrakarn Sineenart , Intawong Kannikar , Chariyalertsak Chonlisa , Khemngern Porntip , Olson Debra , Chariyalertsak Suwat 
Published: May 2022

BackgroundHIV Pre-exposure prophylaxis (PrEP) has demonstrated efficacy and effectiveness among high-risk populations. In Thailand, PrEP has been included in the National Guidelines on HIV/AIDS Treatment and Prevention since 2014. As a part of the national monitoring and evaluation framework for Thailand’s universal coverage inclusion, this cross-sectional survey was conducted to assess knowledge of, attitudes to and practice (KAP) of PrEP service providers in Thailand.MethodsWe conducted a cross-sectional survey to explore knowledge of, and attitudes towards PrEP among providers from hospital and Key Population Led Health Services (KPLHS) settings. The questionnaire was distributed online in July 2020. Descriptive and univariate analysis using an independent-sample t-test were applied in the analyses. Attitudes were ranked from the most negative (score of 1) to the most positive (score of 5).ResultsOverall, there were 196 respondents (158 from hospitals and 38 from KPLHS) in which most hospital providers are female nurse practitioners while half of those from KPLHS report current gender as gay. Most respondents report a high level of PrEP knowledge and support provision in all high-risk groups with residual concern regarding anti-retroviral drugs resistance. Over two-fifths of providers from both settings perceive that PrEP would result in risk compensation and half of KPLHS providers are concerned regarding risk of sexual transmitted infections. Limited PrEP counselling time is a challenge for hospital providers.ConclusionsService integration between both settings, more involvement and distribution of KPLHS in reaching key populations would be essential in optimizing PrEP uptake and retention. Continuing support particularly in raising awareness about PrEP among healthcare providers and key populations, facilities and manpower, unlimited quota of patient recruitment and PrEP training to strengthen providers’ confidence and knowledge would be essential for successful PrEP implementation.
Wrap & Plant Technology: An Innovative and Cost-Effective Method for Seed Yam Treatment for Nematode Control in Fields
Authors: Dedehouanou Houinsou 
Published: May 2022

ABSTRACT
In West Africa, seed yam represents an important source of nematode inoculums in yam fields and a major cause of the disease perpetuation. To enhance nematode control on yam (Dioscorea spp.), a pilot participatory field evaluation was conducted in Benin on nematode control potential of abamectin-treated banana paper (treatment A) using seed wrap method. An additional seed yam wrapped with untreated paper (treatment B) is also considered. Both treatments A & B are then compared to unwrapped seed yam representing the farmers’ practice (FP). In each field, plots are arranged in a randomized complete block design with five replicates. The effects of seed yam treatment on nematode control in fields, gustatory qualities of yam tubers, and both social and profitability studies of the technology were assessed. In the present paper, only the study related to the profitability based on the Net Margin (NM) and the ratio Cost/Profit is presented. Results reveal advantages of treatments A and B over (FP). In fact, production statistics from treatments A and B are significantly higher than those from (FP). Based on the "willingness to pay" approach, the profitability study shows that treatment A has a Net Margin of approximately 153.7% that of (FP). Concerning the ratio Cost/Profit, 100 FCFA (West African CFA franc) spent in yam production using this new technology generates around 79.3 FCFA against 59.9 FCFA for (FP). Despite the success of this pilot study, input prices must be monitored before scaling up this innovation to the other agro-ecological regions of Benin.
Key-words: Nematode control, Dioscorea spp., cost effectiveness, input prices, Wrap & plant technology, Benin
Combined effects of exercise training and D‐allulose intake on endurance capacity in mice
Authors: Tsuzuki Takamasa , Suzuki Ryo , Kajun Risa , Yamada Takako , Iida Tetsuo , Liu Bingyang , Koike Teruhiko , Toyoda Yukiyasu , Negishi Takayuki , Yukawa Kazunori 
Published: May 2022

AbstractThis study investigated the combined effects of exercise training and D‐allulose intake on endurance capacity in mice. Male C57BL/6J mice were fed either a control diet (Con) or a 3% D‐allulose diet (Allu) and further divided into the sedentary (Sed) or exercise training (Ex) groups (Con‐Sed, Con‐Ex, Allu‐Sed, Allu‐Ex, respectively; n = 6–7/group). The mice in the Ex groups were trained on a motor‐driven treadmill 5 days/week for 4 weeks (15–18 m/min, 60 min). After the exercise training period, all mice underwent an exhaustive running test to assess their endurance capacity. At 48 h after the running test, the mice in the Ex groups were subjected to run at 18 m/min for 60 min again. Then the gastrocnemius muscle and liver were sampled immediately after the exercise bout. The running time until exhaustion tended to be higher in the Allu‐Ex than in the Con‐Ex group (p = 0.08). The muscle glycogen content was significantly lower in the Con‐Ex than in the Con‐Sed group and was significantly higher in the Allu‐Ex than in the Con‐Ex group (p < 0.05). Moreover, exercise training increased the phosphorylation levels of adenosine monophosphate‐activated protein kinase (AMPK) in the muscle and liver. The phosphorylation levels of acetyl coenzyme A carboxylase (ACC), a downstream of AMPK, in the muscle and liver were significantly higher in the Allu‐Ex than in the Con‐Sed group (p < 0.05), suggesting that the combination of exercise training and D‐allulose might have activated the AMPK‐ACC signaling pathway, which is associated with fatty acid oxidation in the muscle and liver. Taken together, our data suggested the combination of exercise training and D‐allulose intake as an effective strategy to upregulate endurance capacity in mice. This may be associated with sparing glycogen content and enhancing activation of AMPK‐ACC signaling in the skeletal muscle.
Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats
Authors: Chen Xianzhen , Wang Shiqing , Li Youjiong , Lin Chunjin , Liu Xiaofang 
Published: May 2022

Abstract
Clinically, pentothal sodium has been widely used for primary and general anesthesia induction. Also, it has been used to effectively inhibit convulsion. Pentothal sodium has a strong inhibitory effect on the respiratory center, excessive drug administration, and rapid dose rate that cause death of experimental animals on the respiratory depression. This study used a modified pentothal sodium solution to investigate its anesthetic effect. The pentothal sodium solution was modified based on pentothal sodium upon additions of magnesium sulfate, propylene glycol, and pure ethanol. The anesthetic effect of the modified pentothal sodium on Sprague–Dawley (SD) rats was investigated by comparing traditional pentothal sodium and ketamine; 60 SD rats were randomly divided into three groups. Each group was treated with traditional pentothal sodium, modified pentothal sodium, or ketamine, respectively, via intraperitoneal injection. The symptoms of experimental rats were observed, and onset time and anesthetic time were both recorded. The data were analyzed using statistical software. There were no significant differences in onset time and anesthetic time between the three groups. The variation of onset time and anesthetic time of the group treated with modified pentothal sodium was shorter than that of the other two groups. Furthermore, the number of anesthetic rats after the first injection was significantly higher than that of the other two groups. The modified pentothal sodium is capable of providing a stable anesthetic effect. The function and effect are much better than traditional pentothal sodium and ketamine.
Prostate health index (PHI) as a reliable biomarker for prostate cancer: a systematic review and meta-analysis
Authors: Agnello Luisa , Vidali Matteo , Giglio Rosaria Vincenza , Gambino Caterina Maria , Ciaccio Anna Maria , Lo Sasso Bruna , Ciaccio Marcello 
Published: May 2022

Abstract

Objectives
Prostate cancer (PCa) represents the second most common solid cancer in men worldwide. In the last decades, the prostate health index (PHI) emerged as a reliable biomarker for detecting PCa and differentiating between non-aggressive and aggressive forms. However, before introducing it in clinical practice, more evidence is required. Thus, we performed a systematic review and meta-analysis for assessing the diagnostic performance of PHI for PCa and for detecting clinically significant PCa (csPCa).

Methods
Relevant publications were identified by a systematic literature search on PubMed and Web of Science from inception to January 11, 2022.

Results
Sixty studies, including 14,255 individuals, met the inclusion criteria for our meta-analysis. The pooled sensitivity and specificity of PHI for PCa detection was 0.791 (95%CI 0.739–0.834) and 0.625 (95%CI 0.560–0.686), respectively. The pooled sensitivity and specificity of PHI for csPCa detection was 0.874 (95%CI 0.803–0.923) and 0.569 (95%CI 0.458–0.674), respectively. Additionally, the diagnostic odds ratio was 6.302 and 9.206, respectively, for PCa and csPCa detection, suggesting moderate to good effectiveness of PHI as a diagnostic test.

Conclusions
PHI has a high accuracy for detecting PCa and discriminating between aggressive and non-aggressive PCa. Thus, it could be useful as a biomarker in predicting patients harbouring more aggressive cancer and guiding biopsy decisions.
Role of individual differences in incidental L2 vocabulary acquisition through listening to stories: metacognitive awareness and motivation
Authors: Shin Hye Won , Sok Sarah , Do Juhyun 
Published: May 2022

Abstract
This study examined the moderating role of two individual difference factors, metacognitive awareness of listening and motivation, in young second language (L2) learners’ incidental vocabulary acquisition from listening to stories. Participants were 66 fifth-grade English as a Foreign Language learners in South Korea who were randomly assigned to one of two groups: listening to stories or control. A vocabulary meaning recognition test was administered as a pretest, posttest, and delayed posttest. Self-reported questionnaires were employed to assess participants’ metacognitive awareness and motivation. Metacognitive awareness of listening, or more specifically, mental translation strategies, were shown to moderate the effects of treatment such that L2 learners who indicated greater awareness of translation strategies learned more vocabulary from listening to stories than L2 learners who had less awareness of these strategies. Motivation also moderated the effects of treatment such that L2 learners who had higher intrinsic motivation to learn English were able to acquire more vocabulary through listening to stories than learners who were less motivated.
Comparative analysis between homogeneous and heterogeneous models of gas cooled fast reactor core (GFR-2400)
Authors: Ibrahim Amr , Aziz Moustafa , El-Fiki Soad A. , Galahom Ahmed Abdelghafar 
Published: May 2022

Abstract
The main objective of the presented work is to investigate the effectiveness of homogenization of the GFR-2400 core in simulating its neutronic characteristics. To explore and evaluate the neutronic behavior of the large scale Gas cooled Fast Reactor GFR-2400 core, two computer models (homogeneous and heterogeneous) were designed using the MCNPX code. The designed heterogeneous model has been validated by comparing its results with a previously published paper. The results of both models were compared with each other to study the effect of fuel homogeneity on the radial flux and power distribution through the core. As part of a safety analysis of the reactor core for both designs, the reactivity worth of control rods, Effective delayed neutron fraction (ß
eff), Doppler constant and Depressurization effect have been analyzed and compared. The variations of the effective multiplication factor (k
eff), the minor actinides concentration and the most important fission products as a function of operation time have been investigated for the presented designs.
Structures devised by the generalizations of two graph operations and their topological descriptors
Authors: Raza Hassan , Waheed Muhammad , Jamil Muhammad Kamran , Azeem Muhammad 
Published: May 2022

Abstract
Graph theory served in different fields of sciences, especially in chemistry in which creating complex structures and studying their enormous properties. Graph operation is a tool to construct complex chemical structures using basic graphs. While studying their properties, topological descriptors are a well-known methodology introduced by chemists, and even after half of a century past, it is still serving. Formally, a topological descriptor or index is a numerical value corresponding to a chemical structure. This numerical value can be easily accessed by a particular equation, for example, the second Zagreb index, the first reformulated Zagreb, and also from the forgotten topological descriptor. In this particular work, we generalized two existing graph operations, and by using these newly developed graph operations, we created two complex structures by using two graph operations, namely, the corona product and double graph operation. Furthermore, to evaluate the chemical properties of these newly generated structures, we used the methodology of topological descriptors, particularly the first and second Zagreb, the first reformulated Zagreb, and forgotten topological descriptors. Moreover, we also presented the closed formulas of the first and second Zagreb co-indices for these newly generated structures.
Inverse design of structural color: finding multiple solutions via conditional generative adversarial networks
Authors: Dai Peng , Sun Kai , Yan Xingzhao , Muskens Otto L. , de Groot C. H. (Kees) , Zhu Xupeng , Hu Yueqiang , Duan Huigao , Huang Ruomeng 
Published: May 2022

Abstract
The “one-to-many” problem is a typical challenge that faced by many machine learning aided inverse nanophotonics designs where one target optical response can be achieved by many solutions (designs). Although novel training approaches, such as tandem network, and network architecture, such as the mixture density model, have been proposed, the critical problem of solution degeneracy still exists where some possible solutions or solution spaces are discarded or unreachable during the network training process. Here, we report a solution to the “one-to-many” problem by employing a conditional generative adversarial network (cGAN) that enables generating sets of multiple solution groups to a design problem. Using the inverse design of a transmissive Fabry–Pérot-cavity-based color filter as an example, our model demonstrates the capability of generating an average number of 3.58 solution groups for each color. These multiple solutions allow the selection of the best design for each color which results in a record high accuracy with an average index color difference ΔE of 0.44. The capability of identifying multiple solution groups can benefit the design manufacturing to allow more viable designs for fabrication. The capability of our cGAN is verified experimentally by inversely designing the RGB color filters. We envisage this cGAN-based design methodology can be applied to other nanophotonic structures or physical science domains where the identification of multi-solution across a vast parameter space is required.
Potent neutralization by monoclonal human IgM against SARS‐CoV‐2 is impaired by class switch
Authors: Callegari Ilaria , Schneider Mika , Berloffa Giuliano , Mühlethaler Tobias , Holdermann Sebastian , Galli Edoardo , Roloff Tim , Boss Renate , Infanti Laura , Khanna Nina , Egli Adrian , Buser Andreas , Zimmer Gert , Derfuss Tobias , Sanderson Nicholas S R 
Published: May 2022

AbstractTo investigate the class‐dependent properties of anti‐viral IgM antibodies, we use membrane antigen capture activated cell sorting to isolate spike‐protein‐specific B cells from donors recently infected with SARS‐CoV‐2, allowing production of recombinant antibodies. We isolate 20, spike‐protein‐specific antibodies of classes IgM, IgG, and IgA, none of which shows any antigen‐independent binding to human cells. Two antibodies of class IgM mediate virus neutralization at picomolar concentrations, but this potency is lost following artificial switch to IgG. Although, as expected, the IgG versions of the antibodies appear to have lower avidity than their IgM parents, this is not sufficient to explain the loss of potency.
STUDENTS’ PROBLEMS OF ACADEMIC WRITING COMPETENCIES, CHALLENGES IN ONLINE THESIS SUPERVISION, AND THE SOLUTIONS: THESIS SUPERVISORS’ PERSPECTIVES
Authors: Nurkamto Joko , Djatmika Djatmika , Prihandoko Lastika Ary 
Published: May 2022

The COVID-19 outbreak has brought about the offline-to-online transformation of EFL undergraduate thesis supervision along with its challenging complexities. Anchored in a combination of realistic and constructivist epistemologies, this explanatory sequential design of mixed-method research aimed to investigate students’ problems of academic writing competencies, challenges in online thesis supervision, and solutions to the problems and challenges according to thesis supervisors’ perspectives. Data was first gathered using a closed-ended questionnaire involving fifty thesis supervisors from Central Java and Papua universities as the respondents. Descriptive statistical analyses were conducted to process this data. Twenty-three of the respondents were then purposively selected for interviews and focus group discussions, the data of which was analyzed using interactive model-driven analyses. This study revealed students’ problems of academic writing competencies covering the dimensions of thesis elements and writing performances. Subsequently, multiple challenges were unraveled pertaining to the issues of technological competencies, time management, complexities of students’ field research, and students’ unstable motivation. The supervisors proposed contextual solutions and those demonstrating their interventions for improving students’ metacognition, self-efficacy, and growth mindsets in academic writing. Further studies are expected to work on more in-depth mixed-method investigations that examine the interactions of motivational and strategic constructs predicting academic writing competencies to dive more deeply into the problems, challenges, and solutions concerning the online thesis supervision