bluuebunny/crossref_metadata_2025_split huggingface dataset:
DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p/NAT10 axis
Authors: Du Chunjuan , Han Xia , Zhang Yanyan , Guo Fengli , Yuan Haibin , Wang Feng , Li Mianli , Ning Fangling , Wang Weibo 
Published: December 2022

Abstract
The long noncoding RNA DARS-AS1 was aberrantly expressed and participated in several human cancer progressions, whereas whether DARS-AS1 is involved in human gastric cancer remains unclear. This study aimed to investigate the influence of DARS-AS1 on gastric cancer progression and explore the potential regulatory network of DARS-AS1/miR-330-3p/NAT10. The expression levels of DARS-AS1, miR-330-3p, and NAT10 were measured by quantitative real-time polymerase chain reaction. The CCK-8 assay and Transwell assay were used to determine the cell viability, migration, and invasion capacities, respectively. The target association between miR-330-3p and DARS-AS1 or NAT10 was confirmed using a luciferase reporter assay. In result, DARS-AS1 levels were elevated in tumor tissues and associated with shorter overall survival in patients with gastric cancer. Knockdown of DARS-AS1 could hamper cell viability, migration, and invasion in gastric cancer cells. DARS-AS1 acts as a competitive endogenous RNA to regulate the NAT10 expression by sponging miR-330-3p in gastric cancer cells. In conclusion, DARS-AS1 was elevated in gastric cancer, and DARS-AS1/miR-330-3p/NAT10 signaling offered some new horizons for predicting prognosis and a novel therapeutic method for the treatment of gastric cancer.
Síndrome de burnout em docentes universitários dos cursos de saúde
Authors: Oliveira Henry Johnson Passos de , Silva Victor Manoel Pereira da , Silva Raphael Alves da , Vasconcelos Selene Cordeiro , Oliveira Maria de Jesus Gabriela da Silva , Inácio Antônio Sávio , Lima Murilo Duarte da Costa , Silva Felicialle Pereira da 
Published: December 2022

Objetivo A síndrome de burnout é definida como um fenômeno psicossocial em resposta crônica aos estressores interpessoais no ambiente de trabalho. Avaliar a síndrome de burnout em docentes dos cursos da área de saúde.
Método Estudo descritivo, transversal, com abordagem quantitativa. Para coleta de dados foi utilizado o Maslach Burnout Inventory, além de um questionário socioeconômico. Utilizou-se do teste exato de Fisher para verificar se existe associação entre as variáveis sociodemográficas e a presença de burnout.
Resultados Participaram do estudo 57 docentes, a maior parte do sexo feminino (n=39; 68,4%) e com tempo de atuação profissional acima de 10 anos (n=30; 52,6%). A maioria possui outro vinculo (n=43; 75,4%) e dedica mais de 40 horas semanais ao trabalho (n=35; 61,4%). A variável lazer apresentou-se estatisticamente significante em relação a ter ou não burnout evidenciando maior proporção de adoecimento entre os que referiram não sair a lazer. Observou-se percentuais elevados de exaustão emocional, despersonalização e baixa realização profissional revelando uma alta prevalência da síndrome de burnout entre os docentes.
Conclusão Esses achados merecem atenção para o acompanhamento dos fatores psicossociais e organizacionais do processo laboral que possam intervir na qualidade de vida e nas condições de saúde desse trabalhador.
Proyección de brecha de especialistas en nefrología en Uruguay 2020-2050: aplicación de un modelo de dinámica de sistemas
Authors: Cavalleri Ferrari Fiorella , Buglioli Marisa , Silvariño Ricardo , Boggia José 
Published: December 2022

Objetivo Estimar el equilibrio/desequilibrio entre la oferta y la necesidad de nefrólogos en Uruguay para el año 2020 así como la tendencia hacia el 2050. Métodos Se desarrolló un modelo de simulación, aplicando la metodología de dinámica de sistemas con dos componentes: el de oferta y el de necesidad. Se definió 2020 como el año base y un horizonte de proyección hasta 2050. Se comparó la oferta y la necesidad en el periodo de proyección para establecer la brecha tanto en términos absolutos como relativos. Resultados La proyección de brecha para todos los escenarios considerados es de superávit en la mayor parte del periodo analizado. Conclusiones El trabajo aporta insumos respecto de aquellos parámetros sobre los que se puede incidir y que afectan a la oferta de especialistas. El valor de las proyecciones radica en su utilidad para identificar la situación actual y las tendencias futuras a las que deben responder los responsables de la formulación de políticas.
Developing a local supply chain network: The case of Magyar Suzuki in Hungary
Authors: Natsuda Kaoru , Sass Magdolna , Csonka László 
Published: December 2022

AbstractThis study examines the role of Magyar Suzuki in the Hungarian automotive industry. It is the oldest foreign vehicle manufacturer and a symbol of modernisation in the post-communist era in Hungary. Due to EU's local content rule, Magyar Suzuki, in comparison with its counterparts in the region, has established a locally embedded supply chain network. Magyar Suzuki has facilitated process and product upgrading of the local suppliers in Hungary. Nevertheless, functional upgrading is relatively limited due to automotive multinational corporations' recognition of Hungary as a low-cost production location, a low level of R&D operation, and a small domestic market.
Constitutional identity, identities and constitutionalism in Europe
Authors: Allezard Laurianne 
Published: December 2022

AbstractThe notion of Constitutional Identity has attracted much scientific interest. However, it obscures, sometimes in a reductive manner, another legal reality: the existence of other identities, such as national, linguistic, and collective identities. Indeed, a reading of constitutions and constitutional court's decisions in Europe reveals a complex and evolving system of identities behind Constitutional Identity.This paper argues that identity is not just a political argument but also a legal and normative one. From a constitutional law perspective, two main categories can be distinguished: a real identity existing prior to the constitutional norm, and a fictitious identity subsequent to the constitutional norm. These identities are interdependent and are linked to each other; the constitutional courts referring to Constitutional Identity in order to maintain this interweaving. Therefore, Constitutional Identity plays an argumentative function and, by determining the interpretation of constitutional norms and the meaning of constitutional concepts, it gives birth to different forms of constitutionalism in Europe.
Kepuasan Pelanggan Klinik Mata Graha Mirza dengan Menggunakan SERVQUAL dan Importance Performance Analysis pada Gelombang Ketiga Covid 19 di Indonesia
Authors: Irawan Nabilla 
Published: December 2022

Industri kesehatan adalah salah satu industri yang paling krusial pada masa pandemi Covid 19 dimana tidak seperti industri yang lain, industri kesehatan mendapatkan izin untuk tetap beroperasi secara penuh meskipun sedang dalam masa pandemi oleh Pemerintah Indonesia. Pada bulan maret 2022, terdapat gelombang ketiga lonjakan kasus Covid di Indonesia yang mengakibatkan Klinik Mata Graha Mirza harus melakukan perubahan peraturan terhadap para pasien dan karyawannya antara lain mewajibkan setiap pasien swab antigen, melarang pasien dan karyawan untuk makan dan minum di area umum, serta mewajibkan pasien untuk memakai masker ganda dengan tujuan untuk menghindari penyebaran virus Covid 19 di tempat umum dan di tempat pelayanan kesehatan. Penelitian ini dilakukan dengan tujuan untuk mengetahui bagaimana pengaruh perubahan peraturan tersebut pada kualitas layanan Klinik Mata Graha Mirza, Pandaan di mata para responden pada saat gelombang ketiga pandemi Covid 19 di Indonesia dengan menggunakan model Service Quality (SERVQUAL) dan Importance-Performance Analysis (IPA) sehingga kita dapat mengetahui tingkat kepuasan serta usulan apa saja yang dapat dilakukan untuk meningkatkan kualitas pelayanan Klinik Mata Graha Mirza.
Representative Acts in Dalia Mogahed's Speech "What it's Like to Be a Muslim in America"
Authors: Fakhriyah Faiqotul , Rohmah Zuliati , Kurjum Mohammad 
Published: December 2022

This present study aims to investigate various kinds of representative acts performed in Dalia Mogahed's speech entitled "What It's like to be a Muslim in America?" and to analyze the Islamic values that may be contained in the speech. As a qualitative research, the data of the current study were collected by searching and watching speech videos on Youtube and downloading the videos and the speech transcripts. In investigating the representative acts of Dalia Mogahed, this study applied Searle's (1976) theory of representative speech acts in analyzing the data in the forms of utterances produced by Dalia that were collected from Dalia's speeches. The data that have been obtained were then classified, analyzed, interpreted, and described. The results show that Dalia's 111 utterances were identified as representative acts, consisting of 54 utterances of stating, 32 utterances of describing, 10 utterances of asserting, 9 utterances of informing, 3 utterances of reporting and 3 utterances of predicting. The representative acts in Dalia's speech are reported to contain some Islamic messages.
Seispy: Python Module for Batch Calculation and Postprocessing of Receiver Functions
Authors: Xu Mijian , He Jing 
Published: December 2022

Abstract
Seispy is a graphical interface Python module for receiver function (RF) calculation and postprocessing in seismological research. Automated workflows of RF calculations facilitate processing large volume of different types of seismic data. The graphical user interface enables an intuitive and straightforward evaluation of RF quality. All parameters about the preprocessing for RF estimation can be adjusted based on user preference. Water-level frequency-domain deconvolution and iterative time-domain deconvolution for RF estimation are available in Seispy. The current version of Seispy contains five main modules for the postprocessing of RF, such as H-κ stacking, crustal anisotropic estimation, harmonic decomposition, and 2D and 3D common conversion point (CCP) stacking. The CCP stacking in the different application scenarios can be handled by a rich collection of modules, such as time-to-depth conversion, 2D or 3D CCP stacking, and adaptive station or bin selection for CCP stacking profiles in a dense seismic array or a linear seismic array. As a Python module, functions in the Seispy can be called easily in Python scripts for other purposes. The modular design allows new functionality to be added in a collaborative development environment. Licensed under GPLv3, Seispy allow users and developers to freely use, change, share, and distribute copies of the package.
The “Glass Beads” Coupling Solution for Borehole and Posthole Accelerometers: Shaking Table Tests and Field Retrievability
Authors: Hollender Fabrice , Theodoulidis Nikolaos , Mariscal Armand , Chaudat Thierry , Steidl Jamison , Bard Pierre-Yves , Roumelioti Zafeiria 
Published: December 2022

AbstractBorehole accelerometers are designed to record strong ground movements at depth. They have become an important complement to surface accelerometers for seismic and earthquake engineering applications. Borehole accelerometers present several implementation challenges, including their coupling with the geological environment. One possible coupling solution is the use of small glass beads, which are placed inside the borehole casing with the purpose of filling in any empty space between the sensor and the casing walls. We carried out a test on a shaking table, over a wide range of peak ground accelerations (PGA from 0.17 to 1.64g), allowing the comparison of the signals between a surface accelerometer and a borehole accelerometer coupled through the glass beads. These tests show that there is almost no difference between the surface and borehole accelerometer signals between 0.5 and 25 Hz, and only very small differences outside this band (0.2–0.5 Hz and 25–80 Hz). Furthermore, experience from multiple vertical accelerometric arrays show that an installation using glass beads is “reversible”, that is, 30 yr after the initial installation it can still be possible to easily extract the accelerometers for repair or replacement, without any problems or damage to the sensors.
“Crisis Rhetoric” and Derogations from the AFSJ: Is EU Asylum Policy Discriminatory or does its Implementation Reflect the Rule of Law?
Authors: Kienast Julia 
Published: December 2022

This paper analyses the language of EU leaders and its influence on the implementation of EU asylum law by triggering derogations, exceptions and amendments. It compares this process with regards to the 2015 refugee crisis, the Belarus border crisis and the current Ukrainian crisis to portray how the reaction to similar facts differs and, hence, to show how EU asylum policy suffers from a lack of rule of law. As the crisis in Ukraine unfolds, one can observe how strongly the narrative of EU leaders differs regarding these refugees compared to those from, e.g., Syria and Afghanistan in previous years. It shows a “U-turn” of the EU’s agenda since 2015. Hence, it has become clear that the problem lies less in sufficient contingencies for a sudden influx, but rather a feeling – or lack – of solidarity. From a legal perspective, there is no distinction between the responsibility for asylum applicants based on their nationality. To the contrary, refugee protection builds on the prohibition of discrimination. This has potentially negative implications for the rule of law in the EU. Hence, this paper investigates how EU leaders “talk” their way into applying or not applying EU law and even create EU law at their will simply by describing the arrivals as a security threat, a “hybrid attack” or instead as neighbors in need, as “family”.
Received: 31 July 2022 Accepted: 13 October 2022
Addressing Migrant Smuggling in the European Union. Challenges for a Non-Criminalized, Coordinated and Effective Response
Authors: Jordana Santiago Mirentxu 
Published: December 2022

Migrant smuggling is a highly complex criminal phenomenon. Clearly cross-border in nature, smuggling frequently involves the participation of organized criminal groups. A coherent approach to these activities requires a clear and correctly implemented regulation, in the case of the EU the reference regulation is the ‘Facilitators’ package’. In the present contribution several controversies that this framework entails will be pointed out, especially the excessive criminalization and the neglect of the human rights perspective. Furthermore, the eradication of smuggling requires the sum of efforts and coordinated action of different actors such as national authorities and European agencies. In this paper some actions carried out by Europol in the Mediterranean will be studied. Focusing on the role of this law enforcement agency in the hotspots, the contribution of the information gathered and the benefits for Eurojust will be evaluated.
Received: 31 July 2022Accepted: 10 October 2022
Las recreaciones históricas como estrategia de turismo cultural y cohesión social: la Boda de El Empecinado, un estudio de caso en España
Authors: Acebes Palenzuela María Ángeles , Ríos Elorza Serafín 
Published: December 2022

Esta investigación parte de que las comuni­dades deben ser entendidas y valoradas co­mo espacios socialmente construidos donde perviven historia, cultura, tradiciones, saberes, capacidades, recursos y bienes pa­trimoniales que les otorgan identidad. Con esta premisa, las recreaciones históricas se plantean como una estrategia que parte del rescate y de la valoración de eventos y tradiciones históricas locales para, mediante su representación, configurar un atractivo turístico cultural auténtico e innovador de bajo coste, que posibilite cohesión social y conservación de la memoria histórica local, así como dinamizar la economía en beneficio de la población residente. Este artículo presenta resultados de inves­tigación de la recreación de la Boda de El Empecinado, evento histórico emblemáti­co de Castrillo de Duero, localidad de la Ribera del Duero, provincia de Valladolid (España), durante el periodo 2014-2019. La metodología incluyó revisión documental histórica y observación participante con entrevistas en profundidad.
DESAFIOS DA GESTÃO ESCOLAR DURANTE A PANDEMIA DA COVID-19
Authors: Gomes de Oliveira Laini , Casagrande Samira 
Published: December 2022

Este artigo apresenta os resultados de uma pesquisa que tem por objetivo analisar os desafios enfrentados pela gestão escolar no decorrer da pandemia da Covid-19. A presente pesquisa foi de natureza básica, utilizando, para a coleta de dados, uma abordagem qualitativa, tendo como instrumento o roteiro de perguntas, aplicado de forma online e presencial. Embasados nas publicações ao longo dos anos sobre gestão escolar apresentadas pelos principais autores que nortearam a pesquisa, como Libâneo (2017), Lück (2009), Minayo (2001) e Garay (2011), partiu-se da reflexão do que é gestão escolar e qual o papel do gestor no momento pandêmico. A partir da entrevista, foi possível compreender a situação real vivenciada nesse período, tomando conhecimento sobre os anseios, experiências e práticas desenvolvidas no planejamento, implantação e execução das aulas não presenciais. Os resultados obtidos apontaram para a importância do trabalho coletivo do gestor escolar nesse cenário, principalmente vinculada à necessidade de assumir novas responsabilidades e desafios.
PALAVRAS-CHAVE: Gestão Escolar; Covid-19; Desafios; Pandemia
ERIC DARCEL E A PAISAGEM: Filosofia fenomenológica, a paisagem e o legado de seu pensamento
Authors: Santos Fernando Barotti dos 
Published: December 2022

Propõe-se a compreender o pensamento dardeliano sobre a paisagem e seu desdobramento na fenomenologia paisagística, questionando se há alguma contribuição do pensamento filosófico da paisagem de Eric Dardel. Logo, esse artigo retoma a base da filosofia da paisagem de Dardel, sob os marcos teorico da pesquisa Holzer e Marandola Jr., para analisarem a influência de filósofos como Martin Heidegger e Maurice Merleau-Ponty, enquanto atores da fenomenologia e os desdobramentos do pensamento dardeliano, a fim de discutir o papel da fenomenologia em sua construção teórica paisagística de outros autores e em outros propostas filosóficas. Utiliza-se pesquisa bibliográfica, método dedutivo e perspectiva qualitativa, com proposta explicativa e descritiva mediante uso de bibliografias, sob abordagem interdisciplinar baseada principalmente nas áreas filosóficas e geográficas. Reconhece-se a importância do seu pensamento sobre o tema da paisagem e a sua influência em outros estudiosos.
NURSING STUDENTS’ MOTIVATION TOWARD BLENDED LEARNING AT A PRIVATE UNIVERSITY IN TANGERANG
Authors: Pratama Daniel Yunihardi , Sopacua Lifia , Sinambela Otniel Natanael , Siswadi Yakobus , Watania Lani Natalia 
Published: December 2022

<p>Motivation can be a driving force for learning that is manifested by the attention of students in blended learning. Blended learning is a combination of online learning and face-to-face learning models. Faculty of Nursing at one private university in Tangerang, is currently developing a blended learning model. The learning is applied to several subjects including Emergency and Critical Care and Disaster Management courses. When the pandemic hit Indonesia, the education system suddenly shifted to online learning. It then pushed students and teachers to master the use of technology, in order to ensure the effectiveness of its implementation. It is indeed significant, given that there are several challenges with a blended learning model, such as internet connection, inadequate facilities or devices, and students’ tendency to procrastinate. It is also important to know students’ perception toward blended learning for the better implementation in the future. This study sought to explore the motivation of nursing students at one private university in Tangerang toward blended learning. To achieve the objective, a descriptive quantitative research method was utilized. The sample consisted of 207 third year nursing students who learned with a blended learning method. The data were collected using The Motivated Strategies for Learning Questionnaire (MSLQ) in May 2020 by online survey form. The data were then analyzed using univariate analysis. It showed that 70% students had high learning motivation while the remaining 30% had low learning motivation. Hence, blended learning was assumed to be effective and worth keeping for nursing education. </p>
High Siglec-15 Expression in Triple-negative Breast Cancer Predicts Poor Prognosis
Authors: Fan Lei , Sui Xin-Yi , Yang Yun-Song , Liu Xi-Yu , Zhou Peng , Shao Zhi-Ming 
Published: December 2022

Abstract
Introduction:
Normalization cancer immunotherapy is a new strategy to treat breast cancer. Sialic acid binding Ig-like lectin 15 (Siglec-15) is a new potential target for normalization cancer immunotherapy. In this study, we evaluated the role of Siglec-15 in breast cancer and investigated the influence of Siglec-15 on the microenvironment of infiltrating immune cells in cancer.
Methods
We performed immunohistochemical staining to analyse Siglec-15 expression in primary invasive breast cancer tissue microarrays. The tissue specimens were from 90 patients. Furthermore, the relationship between Siglec-15 and clinicopathological features was analysed with logistic regression and the Wilcoxon signed-rank test. The association between clinical characteristics and overall survival in The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) patients was assessed.
Results
Immunohistochemical staining of tissue microarrays showed that Siglec-15 had higher expression in breast cancer tissues than in adjacent normal tissues. Breast cancer tissues had higher Siglec-15 expression than normal tissues did. Kaplan–Meier survival analysis suggested that triple-negative breast cancer with high Siglec-15 expression had poorer survival than those with lower Siglec-15 expression (p = 0.042). Furthermore, the high Siglec-15 expression group had low activated dendritic cells, follicular helper T cells, and M1 macrophages.
Conclusions
Siglec-15 had a high expression in breast cancer tissues. High Siglec-15 expression is associated with low activated dendritic cell, follicular helper T cell, and M1 macrophage proportions in breast cancer tissue and predicts poor prognosis in triple-negative breast cancer. Siglec-15 expression may be a potential prognostic molecular marker of poor survival in breast cancer.