bluuebunny/crossref_metadata_2025_split huggingface dataset:
HSPC-SDN: Heuristic Driven Self-Configuring Proactive Controller for QoS-Centric Software Defined Network
Authors: S Sharathkumar , N Sreenath 
Published: August 2022

Abstract
The exponential rise in software computing, low-cost hardware and allied application demands has broadened the horizon for wireless technologies to serve different purposes. Wireless communication systems being central to the modern innovation and industrial growth have given rise to the different communication ecosystems including internet of things, machine to machine communication, wireless local area network, Ad-hoc networks etc. However, coping with non-negotiable service level agreements have forced industries to ensure quality of service (QoS) and quality of experience demands. To meet such demands, software defined network (SDN) has gained widespread attention. The ability to enable higher programmability, flexibility and scalability makes SDN-based system viable; yet, guaranteeing their robustness towards dynamic network, link-failure and adaptive QoS-centric recovery has remained a challenge. In synchronization with this motive, in this paper a robust Heuristic Driven Self-Configuring Proactive Controller is designed for QoS-centric SDN network (HSPC-SDN). Unlike classical data-plane SDN controllers or allied routing solutions, HSPC-SDN performs multi-constraints risk assessment followed by heuristic driven disjoint multiple path selection to support proactive network failure-recovery. HSPC-SDN applies dynamic link-quality information, cumulative congestion degree, probability of successful transmission and link quality change index to perform best forwarding device selection to alleviate any malicious behaviour or malfunction during transmission. Subsequently, it applies genetic algorithm to perform disjoint multiple forwarding cum failure recovery path selection that in conjunction with AND logic function enables self-configuring route recovery to meet fault-tolerant QoS-centric communication. The proposed heuristic model exploits network availability information amalgamated with minimal distance and strictly no-shared component criteria to perform multiple disjoint forwarding-paths cum recovery-path selection. Simulation based results revealed that HSPC-SDN, which can be implemented as a standalone single data-plane controller as well as a middleware routing concept achieves superior average packet delivery rate of 98.03%, packet loss rate of 1.97%, recovery time of 1.66ms and energy consumption of 77.14mJ over other disjoint forwarding path based SDN controllers.
Prescribed Performance Synchronization of Neural Networks with Impulsive Effects
Authors: Wang Zhining , Fan Aili , Lei Youming , Wang Yating , Du Lin 
Published: August 2022

Abstract
In this paper, we consider the prescribed performance synchronization problem of a class of neural networks with impulsive effects. The proposed control scheme can guarantee not only the steady-state performance, but also the transient performance of the system under the impulsive effects. According to Lyapunov stability theory, a sufficient condition for Drive -Response networks synchronization is given. Finally, a numerical simulation is given to show the effectiveness and feasibility of the proposed control scheme.
Management of post-traumatic stress disorder symptoms by yoga: an overview
Authors: Laplaud Nina , Perrochon Anaïck , Gallou-Guyot Matthieu , Maarten Moens , Goudman Lisa , David Romain , Rigoard Philippe , Billot Maxime 
Published: August 2022

Abstract
Background: Posttraumatic stress disorder (PTSD) can occur after facing with trauma. While PTSD management strategies include first-line pharmacotherapy and psychotherapy, mind-body therapies, such as yoga, are applied in PTSD population. This overview aimed to summarize the effectiveness of yoga interventions on PTSD symptoms in adults in a systematic review including randomized controlled trials (RCTs).Method: We searched for systematic reviews with or without meta-analysis of RCTs involving adults with PTSD diagnosis or trauma history. The search was conducted until April 2022, through six databases (Cochrane Database, MEDLINE (Pubmed), Scopus, Embase, CINHAL and PEDro). The primary outcome was the evolution of PTSD symptoms throughout the intervention. Secondary outcomes included follow-up, safety, adherence, and cost of the intervention. Two authors independently performed the selection, data extraction and risk of bias assessment with the AMSTAR 2 tool and overlap calculation. This overview is a qualitative summary of the results obtained in the selected studies.Results: Eleven systematic reviews were analyzed, of which 8 included meta-analyses. The overlap between studies was considered as very high (corrected covered area of 21 %). Fifty-nine RCTs involving 4434 participants were included. Yoga had significant small-to-moderate effect-size on PTSD symptoms decrease in 7 and non-significant effects in 1 systematic review with meta-analysis. All systematic reviews without meta-analysis found beneficial effects of yoga on PTSD. Secondary outcomes were not sufficiently assessed to provide clear evidence. Results should be interpreted with caution as 1 systematic review was rated as at moderate risk of bias, 3 as low and 7 as critically low. Conclusions: While yoga therapy seems promising for decreasing PTSD symptoms, future research should standardize yoga therapy duration and consider long-term efficacy to better delineate yoga therapy efficacy in PTSD patients.
Systemic review of age brackets in pediatric emergency medicine literature and the development of a universal age classification for pediatric emergency patients - the Munich Age Classification System (MACS)
Authors: Althammer Alexander , Prückner Stephan Dr.med. , Gehring Christian Dipl.-Geogr , Lieftüchter Victoria Dr.med. , Trentzsch Heiko Dr.med. , Hoffmann Florian PD Dr.med. 
Published: August 2022

Abstract
Currently arbitrary, inconsistent and non-evidence-based age cutoffs are used in the literature to classify pediatric emergencies. None of these classifications have valid medical rationale. This leads to confusion and poor comparability of the different study results. To clarify this problem, this paper presents a systematic review of the commonly used age limits from 115 relevant articles. In the literature search 6226 articles were screened. To be included, the articles had to address the following three topics: “health services research in emergency medicine”, "pediatrics" and "age as a differentiator". Physiologic and anatomic principles with reference to emergency medicine were used to solve the problem to create a medically based age classification for the first time. The Munich Age Classification System (MACS) presented in this paper is thus consistent with previous literature and is based on medical evidence. In the future, MAC should lead to ensure that a uniform classification is used. This will allow a better comparability of study results and enable meta-analyses across studies.
EHTT2022 Grinding characteristics of MoS2-coated brazed CBN grinding wheels in dry grinding of titanium alloy
Authors: Zhao Junshuai , Zhao Biao , DING Wenfeng , Wu Bangfu , Han Ming , Xu Jiuhua , Liu Guoliang 
Published: August 2022

Abstract
As an important green manufacturing process, dry grinding has problems such as high grinding temperature and insufficient cooling capacity. Aiming at the problems of sticking and burns in dry grinding of titanium alloys, grinding performance evaluation of molybdenum disulfide (MoS2) solid lubricant coated brazed cubic boron carbide (CBN) grinding wheel (MoS2-coated CBN wheel) in dry grinding titanium alloys was carried out. The lubrication mechanism of MoS2 in the grinding process is analyzed, and the MoS2-coated CBN wheel is prepared. The results show that the MoS2 solid lubricant can form a lubricating film on the ground surface and reduce the friction coefficient and grinding force. Within the experimental parameters, normal grinding force decreased by 42.5%, and tangential grinding force decreased by 28.1%. MoS2 lubricant can effectively improve the heat dissipation effect of titanium alloy grinding arc area. Compared with ordinary CBN grinding wheel, MoS2-coated CBN wheel has lower grinding temperature. When the grinding depth reaches 20 µm, the grinding temperature decreased by 30.5%. The wear of CBN grains of grinding wheel were analyzed by mathematical statistical method. MoS2 lubricating coating can essentially decrease the wear of grains, reduce the adhesion of titanium alloy chip, prolong the service life of grinding wheel, and help to enhance the surface quality of workpiece. This research provides high-quality and efficient technical support for titanium alloy grinding.
Genome-wide identification and characterization of circRNAs in wheat tiller
Authors: Wu Fangkun , Wang Zhiqiang , Zhou Wanlin , Liu Yan , Shi Haoran , Gou Xiangjian , Li Haojie , Lin Yu , Li Caixia , Liu Yaxi 
Published: August 2022

Abstract
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with covalently closed circular structures, which play an important role in transcriptional and post-transcriptional regulation. Tiller is an important agronomic trait that determines plant morphological architecture and affects spike number in wheat. However, no studies on the characteristics and functions of circRNAs involved in the regulation of wheat tiller. Here, we performed a genome-wide identification of circRNAs using ribosomal-depleted RNA-seq from wheat tiller of two pairs near-isogenic lines. A total of 686 circRNAs were identified and distributed on 21 chromosomes of wheat, of which 537 novel circRNAs. Unlike other plants, the majority of these circRNAs (61.8%) were derived from intergenic regions. One circRNA-mediated network associated with tillering was constructed through weighted gene co-expression network analysis, including 323 circRNAs, 117 miRNAs and 968 mRNAs. GO and pathway enrichment analysis of mRNAs suggested that these circRNAs are involved in cell cycle, ncRNA export from nucleus, developmental process, Plant hormone signal transduction, MAPK signaling pathway, RNA degradation. Of these circRNAs, 10 circRNAs are associated with known tillering/branching genes in rice or Arabidopsis thaliana, including OsCesA7, EBR1, DTE1, CRD1, LPA1, PAY1, LRK1, OsNR2, OsCCA1, OsBZR1. In summary, we present the first study of the identification and characterization of circRNAs in wheat tiller, and the results suggest these circRNAs associated with tillering could play an important role in wheat tiller formation and development.
The Usefulness of Heart Rate Variability Spectrum Analysis in Detecting Covert Atrial Fibrillation among Patients with Cryptogenic Stroke
Authors: Komine Yukari , Shimizu Takahiro , Akiyama Hisanao , Hagiwara Yuta , Fukano Takayuki , Kuwata Chihiro , Hasegawa Yasuhiro , Yamano Yoshihisa 
Published: August 2022

Abstract
We examined the usefulness of heart rate variability spectrum analysis as a predictor of covert paroxysmal atrial fibrillation (PAF), an essential risk factor for cryptogenic stroke. Between July 2021 and January 2022, 77 patients (mean age, 76.3 ± 10.9 years) hospitalized with cryptogenic stroke within 3 days of symptom onset were monitored by performing an electrocardiogram (ECG) using telemetry ECG transmitter Duranta®. Autonomic nervous activity up to maximum 30 days after mounting Duranta® was analyzed with and without PAF. PAF was detected in 20 episodes among 8 patients within 1 month. During 24 h post-mounting, 8 patients with PAF had significantly higher levels of low-frequency components (LF), high-frequency components (HF), and HF normalization units and significantly lower levels of LF/HF ratio than those without PAF. Conversely, LF and HF were significantly lower < 1 h before the onset of PAF, especially 15 min before onset. In patients with PAF, parasympathetic activity is predominant in the acute phase of brain infarction; however, parasympathetic activity is reduced just before the PAF occurrence. These findings suggest that autonomic changes may trigger PAF occurrence.
Understanding Deep Learning using Topological Dynamical Systems, Index Theory, and Homology
Authors: Basener Bill 
Published: August 2022

Abstract
In this paper we investigate Deep Learning Models using topological dynamical systems, index theory, and computational homology. These mathematical machinery was invented initially by Henri Poincar\'e around 1900 and developed over time to understand shapes and dynamical systems whose structure and behavior is too complicated to solve for analytically but can be understood via global relationships. In particular, we show how individual neurons in a neural network can correspond to simplexes in a simplicial complex manifold approximation to the decision surface learned by the NN, and how these simplexes can be used to compute topological invariants from algebraic topology for the decision manifold with an explicit computation of homology groups by hand in a simple case. We also show how the gradient of the probability density function learned by the NN creates a dynamical system, which can be analyzed by a myriad of topological tools such as Conley Index Theory, Morse Theory, and Stable Manifolds. We solve analytically for associated the differential equation for a trained NN with a single hidden layer of 256 Neurons applied to the MINST digit dataset, and approximately numerically that it a sink and basin of attraction for each of the 10 classes, but the sinks and strong attracting manifolds lie in regions not corresponding to images of actual digits. Index theory implies the existence of saddles. Level sets of the probability functions are 783-dimensional manifolds which can only change topology at critical points of the dynamical system, and these changes in topology can be investigated with Morse Theory.
Auranofin induces paraptosis by dual inhibition of thioredoxin reductase and proteasome in breast cancer cells
Authors: Seo Min Ji , Lee Dong Min , Jin Hyo Joon , Choi Kyeong Sook 
Published: August 2022

Abstract
Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for oncological application as a repurposed drug. We show here that AF induces paraptosis, a non-apoptotic cell death mode characterized by the dilation of the endoplasmic reticulum (ER) and mitochondria, in breast cancer cells. Although the covalent inhibition of thioredoxin reductase (TrxR), an enzyme that critically controls intracellular redox homeostasis, is considered the primary mechanism of AF’s anticancer activity, knockdown of TrxR1 did not induce paraptosis. Instead, TrxR1 knockdown plus the proteasome inhibitor (PI), bortezomib (Bz), or low doses of AF plus Bz induced paraptosis, mimicking the effect of high-dose AF. These results suggest that the paraptosis induced by high-dose AF requires the inhibition of both TrxR1 and proteasome. We found that TrxR1 knockdown/Bz or subtoxic doses of AF and Bz induced paraptosis selectively in breast cancer cells, sparing non-transformed MCF10A cells, whereas high-dose AF killed both cancer and MCF10A cells. GSH depletion was found to be critically involved in the paraptosis induced by dual TrxR1/proteasome inhibition, independent of ROS generation. In this process, the ATF4/CHAC1 (glutathione-specific gamma-glutamylcyclotransferase 1) axis plays a crucial role in GSH degradation, contributing to proteotoxic stress possibly due to accumulation of the misfolded thiol-containing proteins. These results suggest that the paraptosis-inducing strategy of AF plus a PI may provide an effective therapeutic strategy against pro-apoptotic therapy-resistant cancers and reduce the potential side effects by high-dose AF.
Material-Engineered Bioartificial Microorganisms Enable Efficient Waterborne Viruses Scavenging
Authors: Li Huixin , Cui Yihao , Lin Jiake , Zhang Ying , Hao Haibin , Wang Yang , Xu Yan , Nie Zi-Hao , Zhou Yuemin , Wang Xiao-Yu , Tang Ruikang 
Published: August 2022

AbstractMaterial-based tactics have attracted extensive attention for promoting the functional evolution of organisms. Aiming at design of steerable bioartificial organisms to scavenge pathogenic waterborne viruses, we engineer Paramecia (Para), single-celled water clarifying microorganisms, through integrating a semiartificial and specific virus-scavenging organelle (VSO). To achieve the virus-scavenging function, Fe3O4magnetic nanoparticles modified with a virus-targeted antibody (MNPs@Ab) were efficiently integrated into vacuole organelles of natural Para during the feeding process. The carboxyl group-modified VSO persists inside Para for a long period without compromising the swimming ability. Compared with natural Para, which has no capture specificity and inefficient biodegradation, the VSO-engineered Para (E-Para) efficiently gathers all the viruses in water, and confines them inside the VSO. Moreover, the captured viruses are completely deactivated inside VSOs, because their acidic environment symbiotically elevates the peroxidase-like activity of nano Fe3O4, resulting in the production of virus-deactivated hydroxyl radicals (•OH). After treatment, E-Para can be readily recycled using magnetic fields, thus avoiding further environmental contamination. This strategy has the potential to promote functional evolution of organisms by materials-based artificial organelles, which tailors natural Para into a "living virus scavenger", leading to clearance of waterborne viruses with high efficiency and no extra energy consumption.
Testing the Pace-of-Life Syndrome in the Tree Lizard, Urosaurus ornatus
Authors: Goerge Tyler M , Miles Donald B. 
Published: August 2022

Abstract
The pace-of-life syndrome (POLS) describes covariation between behavioral, physiological, and in some instances thermal traits. The POLS predicts that bolder, more exploratory individuals should have higher metabolic rates, higher physiological performance, and prefer and perform better at high temperatures. Evidence supporting the POLS has been mixed. The goal of this study was to test the POLS in the color polymorphic tree lizard (Urosaurus ornatus) by comparing behavioral, thermal, and physiological performance traits, among all individuals, between the sexes, and among color morphs. We measured behavioral traits using laboratory-based estimates of boldness and exploration, thermal preference traits using a thermal gradient, and used stamina as a measure of locomotor performance. We described the patterns of covariation among the physiological, behavioral, and thermal traits using a principal component analysis. Bolder lizards were more exploratory, but selected cooler body temperatures, which contradicts the relationship predicted by the POLS. We also found that stamina was unrelated to either behavioral or thermal traits. Only boldness and exploration differed among the color morphs: blue and yellow/blue throated males were more exploratory than yellow males and yellow/blue males were bolder than yellow and orange/yellow males. Our results provide little support for the POLS in tree lizards. This study emphasizes the importance of not overgeneralizing the prevalence of the POLS and that in some populations, local conditions and selection pressures may play a larger role in trait correlations than suites of generalized traits.
The anti-angiogenic effect of Astragalus hamosus extract on human umbilical vein endothelial cells cultured on three-dimensional fibrin gel model
Authors: Ai Jafar , Samani Saeed , Kavianpour Maria , Ebrahimi-Barough Somayeh , Abdi Mohammad , Mikaeiliagah Elmira , Bahrami Naghmeh , Rahbari Rezgar , Ai Armin , Mahmoodi Mozaffar 
Published: August 2022

Abstract
Objective: Angiogenesis is necessary for solid tumors to grow and metastasize because it provides oxygen and nutrients for the tumor. By considering similar anti-tumor activity by a similar mechanism in herbal medicine, Astragalus hamosus (A. hamosus) was used in this study in a 3D fibrin gel model against human umbilical vein endothelial cells (HUVECs) to investigate its anti-angiogenic properties.Materials and Methods: A. hamosus extract was tested for cytotoxicity on HUVECs using MTT assay. Flow cytometry was used to examine apoptosis, cell cycle, and proliferation. Also, by qPCR, we quantified the expression of genes related to apoptosis, such as caspase-9, -8, -3, and Bcl-2.Results: Angiogenic activities of HUVECs were significantly decreased after treatment with IC50 concentration of A. hamosus extract. Flow cytometry analysis revealed that the cell cycle in HUVECs was arrested in G0/G1 phase in the 3D model higher than 2D culture. Anti-proliferation activity of the extract decreased the expression of Ki-67, especially in the 3D culture.Conclusion: Based on our results, A. hamosus extract can be used to treat tumors by inhibiting angiogenesis. Also, 3D fibrin gel can simulate anti-proliferative and anti-apoptotic properties of tumors better than 2D culture environment.
Aqueous Humor Cytokines Levels in Polypoidal Choroidal Vasculopathy before and after intravitreal injection of Conbercept
Authors: Yang Hongxia , Yan Xixi , Nie Yuhong , Xiao Xuan 
Published: August 2022

Abstract
Purpose: To retrospectively investigate changes of aqueous humor inflammatory cytokines and angiogenic biomarkers levels in response to intravitreal injection of Conbercept (IVC) treatment for the management of polypoidal choroidal vasculopathy (PCV).Methods: Thirty eyes of 30 PCV patients were enrolled and were received with three consecutive monthly injections of Conbercept. Aqueous humour was collected before the first and third injections. The concentrations of 4 inflammatory cytokines (interleukin (IL)-2, IL-6, IL-10, monocyte chemotactic protein (MCP)-1) and 4 angiogenic biomarkers (vascular endothelial growth factor (VEGF), angiopoietin 2, endothelin 1, IL-8) in the aqueous humor samples of both groups were measured.Results: Concentrations of 2 inflammatory cytokines (IL-10, MCP-1) and 4 angiogenic biomarkers (VEGF, angiopoietin 2, endothelin 1, IL-8) in aqueous humors were significantly higher in eyes of PCV compared with control eyes (all p<0.05), while concentrations of IL-2 and IL-6 did not differ significantly between the two groups (all p>0.05). After IVC treatment, concentrations of 4 cytokines (IL-2, IL-6, IL-10, MCP-1) and VEGF in aqueous humors were significantly decreased in eyes of PCV compared with baseline (all p<0.05), no other angiogenic biomarker (angiopoietin 2, endothelin 1 or IL-8) concentration was significantly altered by IVC treatment.Conclusions: PCV has remarkably distinct inflammatory cytokines and angiogenic biomarkers levels in the aqueous humor. After consecutive Conbercept injection for two monthly, IL-2, IL-6, IL-10, MCP-1 and VEGF levels in aqueous humors from eyes of PCV were strongly inhibited. Our findings suggest that some key inflammatory cytokines and angiogenic biomarkers may be paticipated in the pathogenesis of PCV.