bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feeding activates FGF15‐SHP‐TFEB‐mediated lipophagy in the gut
Authors: Seok Sunmi , Kim Young‐Chae , Zhang Yang , Kong Bo , Guo Grace , Ma Jian , Kemper Byron , Kemper Jongsook Kim 
Published: June 2022

AbstractLysosome‐mediated macroautophagy, including lipophagy, is activated under nutrient deprivation but is repressed after feeding. We show that, unexpectedly, feeding activates intestinal autophagy/lipophagy in a manner dependent on both the orphan nuclear receptor, small heterodimer partner (SHP/NR0B2), and the gut hormone, fibroblast growth factor‐15/19 (FGF15/19). Furthermore, postprandial intestinal triglycerides (TGs) and apolipoprotein‐B48 (ApoB48), the TG‐rich chylomicron marker, were elevated in SHP‐knockout and FGF15‐knockout mice. Genomic analyses of the mouse intestine indicated that SHP partners with the key lysosomal activator, transcription factor‐EB (TFEB) to upregulate the transcription of autophagy/lipolysis network genes after feeding. FGF19 treatment activated lipophagy, reducing TG and ApoB48 levels in HT29 intestinal cells, which was dependent on TFEB. Mechanistically, feeding‐induced FGF15/19 signaling increased the nuclear localization of TFEB and SHP via PKC beta/zeta‐mediated phosphorylation, leading to increased transcription of the TFEB/SHP target lipophagy genes, Ulk1 and Atgl. Collectively, these results demonstrate that paradoxically after feeding, FGF15/19‐activated SHP and TFEB activate gut lipophagy, limiting postprandial TGs. As excess postprandial lipids cause dyslipidemia and obesity, the FGF15/19‐SHP‐TFEB axis that reduces intestinal TGs via lipophagic activation provides promising therapeutic targets for obesity‐associated metabolic disease.
TPO antibody status prior to first radioactive iodine therapy as a predictive parameter for hypothyroidism in Graves’ disease
Authors: Verdickt Sébastien , Van Nes Falco , Moyson Carolien , Maes Toon , Van Crombrugge Paul , Van den Bruel Annick , Decallonne Brigitte 
Published: June 2022

Objective
We investigated whether a positive thyroid peroxidase antibody (TPO Ab) status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for developing hypothyroidism post RAI.

Methods
We performed a retrospective study of patients with Graves’ hyperthyroidism with known TPO Ab status, receiving the first administration of RAI. Patients from four thyroid outpatient centres in Belgium receiving their first RAI therapy between the years 2011 and 2019 were studied. Clinical, laboratory, imaging, and treatment data were recorded from medical charts. Hypothyroidism and cure (defined as combined hypo- and euthyroidism) were evaluated in period 1 (≥2 and ≤9 months, closest to 6 months post RAI) and period 2 (>9 months and ≤24 months post RAI, closest to 12 months post RAI).

Results
A total of 152 patients were included of which 105 (69%) were TPO Ab-positive. Compared to TPO Ab-negative patients, TPO Ab-positive patients were younger, had a larger thyroid gland, and had more previous episodes of hyperthyroidism. In period 1, 89% of the TPO Ab-positive group developed hypothyroidism and 72% in the TPO Ab-negative group (P = 0.007). In period 2, the observation was similar: 88% vs 72% (P = 0.019). In the multivariate logistic regression analysis, a positive TPO Ab status was associated with hypothyroidism in period 2 (adjusted OR: 4.78; 95% CI: 1.27–20.18; P = 0.024). In period 1, the aOR was 4.16 (95% CI: 1.0–18.83; P = 0.052).

Conclusion
A positive TPO Ab status in patients with Graves’ hyperthyroidism receiving the first administration of RAI is associated with a higher risk of early hypothyroidism.
The relationship between adolescent emotion dysregulation and problematic technology use: Systematic review of the empirical literature
Authors: Yang Haibo , Wang Zihao , Elhai Jon D. , Montag Christian 
Published: June 2022

Abstract

Background and aims
We aimed to systematically identify, evaluate and summarize the research on adolescent emotion dysregulation and problematic technology use. We critically appraise strengths and limitations and provide recommendations for future research.

Methods
We followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and conducted a systematic review of published original reports on adolescent emotion dysregulation and problematic technology use published until March 1, 2022. A thorough search preceded the selection of studies matching prespecified criteria. Strengths and limitations of selected studies, regarding design and reporting, were identified based on current best practices.

Results
39 studies met inclusion criteria. All of these studies provided on the relationship between adolescent emotion dysregulation and problematic technology use severity based on self-report data.

Discussion
There was a positive correlation between adolescent emotion dysregulation and the severity of problematic technology use. Beyond this, other variables (such as anxiety, depression, self-esteem, etc.) were also closely related to emotion dysregulation and problematic technology use. Such studies are of importance to better understand cause-effect relations regarding both variables.
İslam Hukuku ve Merî Hukukta Ehliyet ve Mümeyyiz Kavramları ile Ceza Hukuku Açısından Mümeyyiz Çocuğun Tasarruflarının Değerlendirilmesi
Authors: ÇINAR Yusuf 
Published: June 2022

İnsanoğlu yaşamı boyunca haklarıyla, eylem ya da eylemsizlikleriyle hukukun öznesi ve nesnesi durumundadır. Bu yüzden hukuk, insanı anne karnına düşmesinden itibaren değerlendirmiş tasarruflarına uygun hükümler ihdas etmiştir. Roma Hukukundan bu yana hukuk sistemleri “küçüklüğü” farklı değerlendirilmesi gerekli olan bir dönem olarak kabul etmiştir. Bu durum etkisini özellikle yargılanma ve hukuki tasarruflarının geçerliliği konusunda göstermiştir.
Çalışmada ehliyet ve mümeyyiz kavramları, mahiyetleri ve mümeyyiz küçüğün mükellef olup-olmadığı, hukuki tasarruflarının geçerliliği, cezâi açıdan had, kısas, tazîr, tazmin, te’dip gibi uygulamalar karşısında mümeyyiz küçüğün durumu, dava ehliyeti, yemin, şahitlik, ikrar gibi durumlarla muhatap olup olmayacağı gibi konular imkân nisbetinde mukayeseli olarak ele alınmıştır.
Bu çalışmanıın sonucunda, çocukluk ve özelde mümeyyizlik dönemi hakkında daha fazla bilgi sahibi olunması, onun hak ve sorumluluklarının bilinmesiyle durumuna uygun olarak bazı meselelerin ortaya konulması hedeflenmiştir.
Robust Vehicular Communications Using the Fast-Frequency-Hopping-OFDM Technology and the MIMO Spatial Multiplexing
Authors: Hamarsheh Qadri , Daoud Omar Rawhi , Al-Akaidi Marwan , Damati Ahlam , Bani Younis Mohammed 
Published: June 2022

Vehicle-to-Vehicle communication is one of the more emerging technologies in the 21st century from either the comfortable transportation or safer transportation point of view. Vehicle-to-Vehicle communication has one crucial factor, which is the huge information to be shared among vehicles, such as the position, the road data. In such situation, the accurate information sharing process is the most important factor in order to make the vehicles operating in the most feasible way. This work proposes a more robust vehicle communication system to make the existing vehicle transportation system more efficient. In this paper, we propose a fast frequency hopping orthogonal frequency division multiplexing to mitigate the Doppler spread effect on our previously published clustering benchmark. This benchmark contains both of a clustering weighting factor based stage and a multiparallel processing stage. This is in addition to modify the PHY layer of the existing IEEE 802.11p standard in order to impose Multiple Input Multiple Output for higher throughput purposes.The results show a noticeable stability compared to our previously published work. Furthermore, the results are almost exceeds the achieved results from the Lower-ID Distributed Clustering Algorithm (DCA) from both of the speed and communication range.
Lithospheric Structure in Central-East China from Joint Inversion of Surface-Wave Dispersion and CCP-Derived Receiver Function: Implications for Regional Tectonics
Authors: Li Mengkui , Wu Tengfei , Wei Yu 
Published: June 2022

Abstract
To investigate the lithospheric deformation beneath central-east China, we constructed a 3D crustal and uppermost-mantle velocity model of this region by joint inversion of Rayleigh-wave phase velocities and common conversion point-derived receiver functions. The velocity images at the east and west sides of Xuefeng Mountain presented quite different features and a sharp change in lithospheric thickness beneath this mountain, suggesting that this mountain may be the southwestern segment of the boundary between the Yangtze craton (YZC) and the Cathaysia block (CAB). We observed extensive lithospheric thinning in the eastern South China block (SCB), including the CAB and lower YZC. Considering that the eastern SCB is within the influence of the circum-Pacific system and features intensive Mesozoic magmatic activity, we deduced that subduction of the Pacific plate was the main controlling factor of lithospheric thinning. The westward extension of lithospheric thinning in the SCB terminates in the area east of the north–south gravity lineament. We observed a large-scale, low-velocity zone in the uppermost mantle of the southern Trans-North China orogen that penetrates northwestward into the southeastern corner of the Ordos block. The low-velocity zone intrudes into the bottom of the crust and results in crustal thinning in the region. We proposed that both the southern Trans-North China craton and the southeastern Ordos block are suffering ongoing lithospheric mantle modification.
Frog like mucocele: Ranula and its management – Case report
Authors: Singh Shubh Karmanjit , Sharma Parul , Jindal Vikas , Malhotra Divye 
Published: June 2022

The mucocele, the oral ranula, and the cervical, or plunging, ranula are all clinical terminology for a pseudocyst with mucus leakage into the soft tissues surrounding it. These lesions are caused by mucin spilling into the surrounding soft tissues as a result of trauma or congestion to the salivary gland excretory duct. The emergence of mucoceles and ranulas is dependent on the interruption of saliva flow from the salivary glands' secretory mechanism. Two patients with a specific diagnostic were treated and are shown in this article.
PERAN MASYARAKAT DALAM MENGEMBANGKAN KAIN SONGKE UNTUK MENINGKATKAN KONDISI SOSIAL EKONOMI DI DESA RUIS KABUPATEN MANGGARAI
Authors: Hofman Oktavianus , Susanti Nelya Eka , Sari Yuli Ifana 
Published: June 2022

Songke is a typical woven fabric of the Manggarai people who live on the west side of Flores Island. In Indonesia, there are many arts and crafts cultures, one of which is the weaving culture which spreads to all corners of the archipelago, one of which is in Conggo Hamlet, Ruis Village, Manggarai Regency. The purpose of this study was to find out the role of the community in developing Songke cloth to improve the socio-economic condition of the community in Ruis village, Manggarai Regency. The method used in this study is a qualitative method with a descriptive qualitative approach. Collecting data in this study through observation, interviews, and documentation. The data analysis technique used is data reduction, data presentation, and drawing conclusions. The results of the study found that the role of the community in ruis village in developing Songke woven fabrics was very high, this of course can be explained from a point of view such as community involvement in maintaining the quality of Songke woven fabric and being able to provide concepts for developing Songke woven fabric models without having to reduce what is needed. Has been inherited by the ancestors of the Manggarai people. With the tradition of Songke weaving, it is one of the jobs and sources of income for the people of Ruis village in improving the socio-economic conditions of the community.

Abstrak
Kain Songke adalah tenunan khas masyarakat Manggarai yang berdiam di sisi barat Pulau Flores. Di Indonesia terdapat banyak kebudayaan seni kerajinan salah satunya adalah kebudayaan tenun yang tersebar hingga ke seluruh pelosok nusantara, salah satu diantaranya terdapat di Dusun Conggo, Desa Ruis, Kabupaten Manggarai. Tujuan penelitian ini adalah untuk mengetahui bagaimana peran masyarakat dalam mengembangkan kain Songke untuk meningkatkan kondisi sosial ekonomi masyarakat di Desa Ruis Kabupaten Manggarai. Metode yang digunakan dalam penelitian ini yakni metode kualitatif dengan pendekatan kualitatif deskriptif. Pengumpulan data dalam penelitian ini melalui observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan adalah reduksi data, penyajian data, dan menarik kesimpulan. Hasil penelitian diketahui bahwa peran masyarakat di Desa Ruis dalam mengembangkan kain tenun Songke sudah sangat tinggi hal ini tentunya dapat dijelaskan dari sudut pandang seperti keterlibatan masyarakat dalam menjaga kualitas kain tenun Songke dan mampu memberikan konsep-konsep pengembangan model kain tenun Songke tanpa harus mengurangi apa yang telah diwariskan oleh leluhur orang Manggarai. Dengan adanya tradisi tenun Songke menjadikan salah satu lapangan pekerjaan dan sumber pendapatan bagi masyarakat Desa Ruis dalam meningkatkan kondisi sosial ekonomi masyarakat.
TANGGUNG JAWAB ANAK USIA 5-6 TAHUN DI MASA PANDEMI DITINJAU DARI POLA ASUH ORANG TUA DI TK ISLAM TERPADU AN-NUR KEBOMAS GRESIK
Authors: Zahro Alvin Fatimatuz 
Published: June 2022

The responsibility of early childhood has different in each child, especially during the Covid-19 pandemic. One thing that makes responsibility different is parenting. The aims to determine the attitude of responsibility of children aged 5-6 years during the pandemic in terms of parenting patterns, as well as factors in instilling an attitude of responsibility in children. This research uses a qualitative approach with the type of case study research. The subjects of this study were 6 children with an age range of 5-6 years. Data were collected by using questionnaires, interviews, documentation and observation methods, then analyzed using Milles and Huberman analysis. The data from the research were tested for validity again by using triangulation. The results of the study can be concluded that the attitude of responsibility of children aged 5-6 years during the pandemic in terms of parenting patterns in the Integrated Islamic Kindergarten An-Nur Kebomas Gresik, namely 6 children studied got the results of 2 children with responsibilities already formed and 4 children starting formed. The type of parenting style shows that 4 parents apply democratic parenting, 1 parent applies authoritarian parenting and 1 parent uses permissive parenting. The support and obstacles experienced by parents are environmental factors, gadgets and the child's own factors.
Abstrak
Tanggung jawab anak usia dini mempunyai perbedaan pada setiap anak, apa lagi pada saat pandemi Covid-19. Penelitian ini bertujuan untuk mengetahui bagaimana sikap tanggung jawab anak usia 5-6 tahun selama pandemi ditinjau dari pola asuh orang tua, juga faktor dalam menanamkan sikap tanggung jawab anak. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Subyek penelitian ini adalah 6 anak dengan rentang usia 5-6 tahun. Data dikumpulkan dengan metode angket, wawancara, dokumentasi dan observasi, kemudian dianalisis dengan menggunakan analisis Milles dan Huberman. Data hasil penelitian diuji Kembali kebsahannya dengan menggunakan triangulasi. Hasil penelitian dapat disimpulkan bahwa sikap tangggung jawab anak usia 5-6 tahun di masa pandemi ditinjau dari pola asuh orang tua di TK Islam Terpadu An-Nur Kebomas Gresik yaitu 6 anak yang diteliti mendapatkan hasil 2 anak dengan tanggung jawab sudah terbentuk dan 4 anak mulai terbentuk. Jenis pola asuh orang tua menunjukkan bahwa 4 orang tua menerapkan pola asuh demokratis, 1 orang tua menerapkan pola asuh otoriter dan 1 orang tua menggunakan pola asuh permisif. Dukungan dan hambatan yang di alami orang tua adalah faktor lingkungan, gadget dan faktor anak itu sendiri.
PENANAMAN NILAI-NILAI RELIGIUS MELALUI PEMBIASAAN SHALAT DUHA DAN SHALAT DHUHUR BERJAMAAH DI MI RAUDLATUSSHIBYAN NW BELENCONG
Authors: Hilmiati Hilmiati , Saputra Febria 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui 1) bentuk penanaman nilai-nilai relegius melalui pembiasaan sholat dhuha dan dhuhur berjamaah, 2) strategi dalam menamkan nilai-nilai relegius melalui pembiasaan sholat dhuha dan sholat dhuhr berjamaah. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif yang yaitu dalm mengambarkan atau menafsirkan keadaan mengenai masalah yang akan diteliti menggunakan kata-kata bukan angka. Teknik pengumpulan data dalam penelitian ini menggunakan metode observasi untuk mengamati proses penanaman nilai relegiusitas pada siswa, wawancara untuk mendapatkan data berupa bentuk kegiatan keagamaan dan strategi yang digunakan dalam menanamkan nilai relegiusitas pada siswa, dan dokumentasi untuk memperoleh data berupa visi&misi, infrastruktur, sumberdaya manusia, dan sejarah berdirinya MI Raudlatusshibyan NW Belencong. Adapun teknik analisis data dalam penelitian ini melalui reduksi data, model data, dan penarikan kesimpulan/verifikas data. Sumber data diperoleh dari kepala sekolah, siswa, para guru, dan guru PAI di MI Raudllatusshibyan NW Belencong. Hasil penelitian ini menunjukkan bahwa; 1) Nilai relgius yang ditanamkan melaluipembiasaan sholat dhuha dan sholat dhuhur berjamaah di MI Raudlatusshibyan NW Belencong adalah nilai ibadah, nilai ruhul jihad, nilai akhlak, nilai keteladanan. 2) Strategi dalam menanamkan nilai-nilai relgiusitas melalui pembiasaan sholat dhuha dan dhuhr berjamaah di MI Raudlatusshibyan NW Belencong adalah reward and Punishment, keteladanan, pembiasaan, ajakan (persuasive), aturan atau norma-norma, dan penciptaan suasana relegius disekolah. Simpulan dari penelitian ini adalah karakter relgiusitas melalui pembiasaan sholat dhuha dan dhuhr berjamaah di MI Raudlatusshibyan NW Belencong dengan menggunakan berbagai macam strategi dalam menanamkannya sangat jelas dipaparkan dan sudah sesuai untuk meningkatkan karakter relegiusitas pada siswa.
Gaussian Filter for Brain SPECT Imaging
Authors: Nikolov Nikolay , Makeyev Sergiy , Korostynska Olga , Novikova Tetyana , Kriukova Yelizaveta 
Published: June 2022

Background. The presence of a noise component on 3D images of single-photon emission computed tomo­graphy (SPECT) of a brain significantly distorts the probability distribution function (PD) of the radioactive count rate in the images. The presence of noise and further filtering of the data, based on a subjective assessment of image quality, have a significant impact on the calculation of volumetric cerebral blood flow and the values of the uptake asymmetry of the radiopharmaceutical in a brain.
Objective. We are aimed to develop a method for optimal SPECT filtering of brain images with lipophilic radiopharmaceuticals, based on a Gaussian filter (GF), for subsequent image segmentation by the threshold method.
Methods. SPECT images of the water phantom and the brain of patients with 99mTc-HMPAO were used. We have developed a technique for artificial addition of speckle noise to conditionally flawless data in order to determine the optimal parameters for smoothing SPECT, based on a GF. The quantitative criterion for optimal smoothing was the standard deviation between the PD of radioactive count rate of the smoothed image and conditionally ideal one.
Results. It was shown that the maximum radioactive count rate of the SPECT image has an extremum by changing the standard deviation of the GF in the range of 0.3–0.4 pixels. The greater the noise component in the SPECT image, the more quasi-linearly the corresponding rate changes. This dependence allows determining the optimal smoothing parameters. The application of the developed smoothing technique allows restoring the probability distribution function of the radioactive count rate (distribution histogram) with an accuracy up to 5–10%. This provides the possibility to standardize SPECT images of brain.
Conclusions. The research results of work solve a specific applied problem: restoration of the histogram of a radiopharmaceuticals distribution in a brain for correct quantitative assessment of regional cerebral blood flow. In contrast to the well-known publications on the filtration of SPECT data, the work takes into account that the initial tomographic data are 3D, rather than 2D slices, and contain not only uniform random Gaussian noise, but also a pronounced speckle component.
Comparison of the vasoconstriction effect of phenylephrine and ephedrine on the uterine arteries of pregnant rabbits: A CT imaging-based study
Authors: Li Jingjing , Gao Guangjian , Yin Yibo , Hu Zhangrui , Long Xuechen , Guo Zixuan , Jin Xiaoju , Liu Can , Guo Wenjun 
Published: June 2022

Abstract
Background: Hypotension is one of the most common complications during perioperative obstetric surgery and can cause serious adverse reactions in mothers and infants. Phenylephrine and ephedrine are the most widely used vasoconstrictors for preventing and controlling hypotension. However, which of them is the best choice remains unclear due to the lack of solid data on the effects of phenylephrine and ephedrine on uterine placental blood flow. This study aims to investigate the vasoconstriction effect of phenylephrine and ephedrine on the uterine arteries of pregnant rabbits via computed tomography (CT) imaging. Methods: Fifteen near-term pregnant rabbits at 27-29 days of pregnancy were randomly divided into Group P, Group E and Group C. Phenylephrine, ephedrine and normal saline were injected. CT imaging was performed, and the diameters of the uterine arteries were measured to evaluate the contractile response to different drugs. Results: Both phenylephrine and ephedrine induced a similar degree of vasoconstriction on peripheral resistance of the vessels (rostral arteries) (p>0.05). At 5 min and 10 min, the uterine arteries contracted more strongly in response to phenylephrine than ephedrine (p<0.01); after that, there was no significant difference in the diameters of the uterine arteries with the administration of phenylephrine and ephedrine (p>0.05). Conclusion: In summary, compared with ephedrine, phenylephrine had a faster effect, and resulted in stronger contraction of the uterine arteries, indicating a greater impact on placental perfusion. Therefore, in clinical practice, ephedrine has more favorable effects than phenylephrine on uterine and placental circulation.
Quantum Analysis of Squiggle Data
Authors: Nagy Naya , Nagy Marius , Stuart-Edwards Matthew , Mitchell Liam , Zovoilis Athanasios 
Published: June 2022

Abstract
Squiggle data is the numerical output of DNA and RNA sequencing by the Nanopore next generation sequencing platform. Nanopore sequencing offers expanded applications compared to previous sequencing techniques but produces a large amount of data in the form of current reads over time. The analysis of these reads require more complex and computationally intensive algorithms than previous sequencing technologies. The purpose of this study is to investigate in principle the potential of using quantum computers to speed up Nanopore data analysis. Quantum circuits are designed to extract major features of squiggle current reads. The circuits are analyzed theoretically in terms of size and performance. Practical experiments on IBM QX show the limitations of the state of the art quantum computer to tackle real life squiggle data problems. Nevertheless, pre-processing of the squiggle data using the inverse wavelet transform, as experimented and analyzed in this paper as well, reduces the dimensionality of the problem in order to fit a reasonable size quantum computer in the hopefully near future.