bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN MEDIA CD INTERAKTIF MENGGUNAKAN MACROMEDIA FLASH
Authors: Huda Fatkhan Amirul , Thoharudin Munawar 
Published: August 2022

ABSTRACTThis research aims to describe the development of interactive CD media using Macromedia Flash 8 on classification of animal subject for elementary school grade IV. The method in this research is research and development that combining research and development method according to Borg & Gall and ASSURE, that consist of 7 steps. These steps include: research and information, analyze learner characteristics, state objective, select or modify media, utilize, require learner response and evaluate. The results showed that the developed interactive CD has been feasible based on development steps. The results of media validation and material validation obtained scores average respectively by 90,62% and 99%, so interactive CD media feasible to applied in for elementary school grade IV. Then, based on student learning outcomes on a small scale trial shown 92% of students score is ≥ 63. On a large scale trial in SDN 23 Menyumbung and SDN 01 Kenukut the classical of student learning outcomes respectively increased for 53% and 34%. It can be concluded that the development of interactive cd media using macromedua flash 8 on classification of animal subject feasible to applied for elementary school grade IV.Keywords: Interactive CD; Instructional Media; Macromedia Flash 8ABSTRAKPenelitian ini bertujuan mendeskripsikan pengembangan media CD interaktif menggunakan Macromedia Flash 8 pada materi menggolongkan hewan untuk siswa kelas IV Sekolah Dasar. Metode penelitian yang digunakan adalah penelitian dan pengembangan dengan mengkombinasikan metode penelitian dan pengembangan menurut Borg & Gall dan ASSURE yang terdiri dari 7 langkah, meliputi: penelitian dan pengumpulan data (research and information), analyze learner characteristics (menganalisis karakteristik umum kelompok sasaran), state objective (menyatakan atau merumuskan tujuan pembelajaran), select or modify media (memilih, memodifikasi, atau merancang dan mengembangkan materi dan media yang tepat), utilize (menggunakan materi dan media), Require learner response (meminta tanggapan dari siswa) and evaluate (mengevaluasi proses belajar). Hasil penelitian menunjukkan bahwa CD interaktif yang dikembangkan dinyatakan layak sesuai dengan langkah-langkah pengembangan. Berdasarkan hasil validasi media dan hasil validasi materi yang ditunjukkan dengan rata-rata perolehan skor masing-masing sebesar 90,62% dan 99%, maka media CD interaktif layak diterapkan pada siswa kelas IV sekolah dasar. Kemudian berdasarkan tes hasil belajar siswa pada uji coba terbatas menunjukkan 92% siswa mendapat skor ≥63. Sedangkan pada uji coba skala luas di Sekolah Dasar Negeri 23 Menyumbung dan Sekolah Dasar Negeri 01 Kenukut ketuntasan klasikal hasil belajar siswa meningkat masing-masing sebesar 53% dan 34%. Dengan demikian dapat disimpulkan bahwa pengembangan media CD interaktif menggunakan macromedia flash 8 pada materi menggolongkan hewan layak diterapkan pada siswa kelas IV Sekolah Dasar.Kata Kunci: CD Interaktif; Media Pembelajaran; Macromedia Flash 8
PERANCANGAN APLIKASI UJIAN ONLINE BERBASIS WEBSITE
Authors: Gamaliel Fritz , Arliyanto P. Yudi Dwi 
Published: August 2022

Sistem Informasi ujian secara online merupakan salah satu bagian sistem informasi pendidikan jarak jauh melalui media teknologi internet. Perguruan Tinggi menggunakan Moodle sebagai aplikasi ujian online penerimaan mahasiswa baru, dalam hal ini Moodle tidak terintegrasi dengan sistem internal Perguruan Tinggi. Konsep Ujian online yang tidak terkait ruang dan waktu dapat menjadi solusi atas kendala yang ada pada metode ujian yang konvensional. Proses Pengumpulan data menggunakan metode observasi, wawancara dan study pustaka. Dalam pengembangan sistem menggunakan metode Extreme Programming. Alat perancangan system yang di gunakan adalah Class diagram, dan Use case diagram. Sedangkan untuk pembuatan sistem informasi ujian secara online pada perguruan tinggi penulis menggunakan Bahasa pemograman yang digunakan adalah PHP dan MySQL sebagai databasenya. Berdasarkan hasil penelitian maka diperoleh sistem informasi ujian secara online pada perguruan tinggi. Soal yang disajikan dalam sistem pilihan ganda. Implementasi dari sistem ujian online ini dibuat dengan fasilitas meliputi manajemen soal ujian, manajemen ujian, manajemen data user, dan mengerjakan ujian yang nantinya akan menghasilkan keluaran nilai.
Процес дроселювання в соплових апаратах з поворотними діафрагмами
Authors: Zhyrkov Оleksandr , Usaty Оleksandr , Avdieieva Olena , Torba Yuriy 
Published: August 2022

In the process of developing a method for numerically investigating a plane flow around a nozzle array with a rotary diaphragm, calculations were performed for various degrees of opening of the rotary diaphragm δ and pressure drops π on the array. The article presents some results of a numerical study of the flow in the nozzle channel at the degree of opening of the rotary diaphragm δ = (1…0.15). Modeling and calculations of the flow of the working fluid were performed using the Fluent software package. The construction of computational areas, limited by one inter-blade channel, for a different degree of opening of the diaphragm of the nozzle apparatus has been carried out. The grids for the computational domains were constructed. Calculations were carried out for δ = (1…0.15) and for various degrees of pressure drop across the grate. Because of the performed calculations, flow patterns in the interblade channel and behind it, and the distribution of kinetic energy loss coefficients along the grating front at various degrees of aperture opening at the nozzle inlet, were obtained. Based on the results of the work carried out, the following conclusions can be drawn: the operation of a nozzle array with a rotary diaphragm at different degrees of opening of the rotary diaphragm δ and pressure drops π on the grate can be divided in the range of opening steps δ = (1…0.77) as operation in the nozzle mode, and in the range δ = (0.77…0.15) as in throttle mode; when the angle of attack changes, the values of the kinetic energy loss coefficients increase significantly (up to 25 %) only for π = 0.7 and δ = 1; at π = 0.3 and δ = 1, the coefficient increases slightly (up to 0.5 %); at π = 0.7; 0.3 and δ = 0.3, the coefficient increases to 5 %, while the coefficient ζі changes less relative to the coefficient ζ90 at the calculated angle of attack α0 = 90 grids). The results obtained in this work will be used to develop a technique for numerically investigating the spatial flow around nozzle arrays with rotary diaphragms.
Аналіз роботи гідростатичного підшипника на перехідних режимах
Authors: Nazin Volodymyr 
Published: August 2022

The design of reliable rotor supports for modern high-speed machines is associated with the solution of many complex problems, both theoretical and experimental. Experimental studies play an important role in the system of scientific research and allow improvement and refine mathematical models and the application of numerical methods for their implementation. Experimental studies are usually selective and therefore require careful preparation. The task was set to investigate the characteristics of a hydrostatic bearing in the starting and braking modes. A program of experimental studies of the behavior of a shaft on hydrostatic bearings for the most difficult operating conditions has been developed. The advantages of hydrostatic bearings are given compared with other types of plain bearings, as well as compared with rolling bearings. The effectiveness of hydrostatic bearings is shown, compared with other types of bearings, for modern high-speed machines, in which there is an increase in vibration overloads and vibration displacements. Hydrostatic bearings have proven themselves in all operating modes, including transient ones. A description of the experimental setup for the study of transient modes of operation of the shaft on hydrostatic bearings is given. Studies of the transient modes of operation of the shaft on hydrostatic bearings were conducted at various values of the pressure of the working fluid supply, residual unbalance, as well as various values of the diameter of the hydrostatic bearing. To identify the movement of the rotor on hydrostatic bearings, the values of the amplitudes of oscillations during stationary (steady) movement of the rotor are also presented. It is shown that the comparison of the oscillation amplitudes of the rotor on hydrostatic bearings with a diameter of 0.06 m for the cases of non-stationary and stationary modes of its operation during the acceleration of the amplitude of oscillations in the entire range of rotational speeds is slightly lower (by about 15…20 %) than in the case of a stationary mode of operation of the rotor. When the rotor slows down, the amplitude of the rotor oscillations at high speeds is somewhat larger (by about 7…9 %), and at low speeds it is less by 8…10 % than in the case of a stationary rotor operation. The small influence of the non-stationary nature of the rotor movement on the dynamic characteristics can be explained by its large mass.
The Impact of Commute on Students’ Performance
Authors: Jamil Dawood , Rayyan Mohammed , Abdulla Hameed Ahmed Khalifa , Masood Fatima , Javed Palwasha , Sreejith Anusha 
Published: August 2022

This study aimed to assess the prevalence of commuters in Gulf Medical University (GMU), the impact of length of commute on student's health, and the association between length of commute and academic performance. We conducted a cross-sectional study at Gulf Medical University in the Summer of 2018. It included students 18 years of age and above, regardless of gender, nationality, and year of study, enrolled across the various GMU programs, including Medicine, Dentistry, Basic Medical Science, Physical Therapy, Health Science, Nursing, and Pharmacy. Four hundred and twenty students actively participated in our self-administered questionnaire. Our study determined statistically significant associations between commute and a variety of factors such as physical difficulties, stress, the prevalence of accidents, sleep schedule, etc. Our study concluded that students having longer commutes experienced significant physical difficulties, higher levels of stress, and an increased risk of accidents. Furthermore, we found that students with increased commute times also seemed to lose sleep more frequently than those with shorter commute times. In addition, our study established that commute harms academic performance, as students who commuted for extended periods were shown to have decreased academic performance in addition to having less time to study.
Thioester deprotection using a biomimetic NCL approach
Authors: Villamil Valentina , Saiz Cecilia , Mahler Graciela 
Published: August 2022

The reversibility of the thiol-thioester linkage has been broadly employed in many fields of biochemistry (lipid synthesis) and chemistry (dynamic combinatorial chemistry and material science). When the transthioesterification is followed by a S-to-N acyl transfer to give an amide bond, it is called Native Chemical Ligation (NCL), a high-yield chemoselective process used for peptide synthesis. Recently, we described thioglycolic acid (TGA) as a useful reagent for thioester deprotection both in solution and anchored to a solid-support under mild conditions. Inspired by NCL, in this work, we extended this approach and explored the use of 2-aminothiols for the deprotection of thiols bearing an acyl group. The best results were obtained using cysteamine or L-cysteine in an aqueous buffer pH 8 at room temperature for 30 min. The described approach was useful for S-acetyl, S-butyryl, and S-benzoyl heterocycles deprotection with yields up to 84%. Employing this methodology, we prepared six new analogs 2 of mercaptomethyl bisthiazolidine 1, a useful inhibitor of a wide-range of Metallo-β-Lactamases (MBLs). Compared with the previous methodologies (TGA polymer supported and TGA in solution), the biomimetic deprotection herein described presents better performance with higher yields, shorter reaction times, less time-consuming operations, easier setup, and lower costs.
Novel high strength PVA/soy protein isolate composite hydrogels and their properties
Authors: Zhao Yanteng , Jin Lu , Liu Xin , Liu Xue , Dong Shuling , Chen Yun , Li Xianyu , Lv Xianping , He Meng 
Published: August 2022

High strength polyvinyl alcohol (PVA)/soy protein isolate (SPI) composite hydrogels (EPSG) were constructed by the introduction of PVA into SPI through the crosslinking with epichlorohydrin (ECH) and a freezing-thawing process. The EPSG hydrogels were characterized by scanning electron microscopy, FTIR, X-ray diffraction and compressive test. The results revealed that chemical crosslinking interactions occurred for SPI and PVA during the fabrication process. The composite hydrogels exhibited a homogenous porous structure, indicating certain miscibility between PVA and SPI. The introduction of PVA increased the compressive strength of SPI hydrogels greatly, which could reach as high as 5.38 MPa with the water content ratio of 89.5%. Moreover, the water uptake ratio of completely dried SPI hydrogel (namely xerogel) decreased gradually from 327.4% to 148.1% with the incorporation of PVA, showing a better potential as implants. The cytocompatibility and hemocompatibility of the EPSG hydrogels were evaluated by a series of in vitro experiments. The results showed that the EPSG hydrogels had no cytotoxicity (cell viability values were above 86.7%), good biocompatibility and hemocompatibility, showing potential applications as a direct blood contact material in the field of tissue engineering.
Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy
Authors: Rong Weiwei , Li Jiejia , Wang Lifeng , Luo Shanshan , Liang Tulu , Qian Xunjia , Zhang Xiaodan , Zhou Qinbei , Zhu Yizhun , Zhu Qing 
Published: August 2022

BackgroundLeonurus japonicus Houtt has an obvious efficacy on cardiovascular diseases. As the most representative component in the herb, leonurine has attracted increasing attention for its potential in myocardial ischemia. However, its protective mechanism against myocardial ischemia remains incompletely elucidated.ObjectivesThe present study aimed to reveal the potential mechanism of leonurine in acute myocardial ischemia using a strategy combining metabolomics and network pharmacology.MethodsFirst, a metabolomics method was proposed to identify the differential metabolites of plasma in rats. Then, network pharmacology was performed to screen candidate targets of leonurine against acute myocardial ischemia. A compound-reaction-enzyme-gene network was thus constructed with the differential metabolites and targets. Finally, molecular docking was carried out to predict the binding capability of leonurine with key targets.ResultsA total of 32 differential metabolites were identified in rat plasma, and 16 hub genes were detected through network pharmacology. According to the results of compound-reaction-enzyme-gene network and molecular docking, what was screened included six key targets (GSR, CYP2C9, BCHE, GSTP1, TGM2, and PLA2G2A) and seven differential metabolites (glycerylphosphorylcholine, lysophosphatidylcholine, choline phosphate, linoleic acid, 13-HpODE, tryptophan and glutamate) with four important metabolic pathways involved: glycerophospholopid metabolism, linoleic acid metabolism, tryptophan metabolism and glutamate metabolism. Among them, glycerophospholipid and tryptophan metabolism were shown to be important, since the regulation of leonurine on these two pathways was also observed in our previous metabolomics study conducted on clinical hyperlipidemia patients.ConclusionThis is the first study of its kind to reveal the underlying mechanism of leonurine against acute myocardial ischemia through a strategy combining metabolomics and network pharmacology, which provides a valuable reference for the research on its future application.
Performance of a deep learning tool to detect missed aortic dilatation in a large chest CT cohort
Authors: Pradella Maurice , Achermann Rita , Sperl Jonathan I. , Kärgel Rainer , Rapaka Saikiran , Cyriac Joshy , Yang Shan , Sommer Gregor , Stieltjes Bram , Bremerich Jens , Brantner Philipp , Sauter Alexander W. 
Published: August 2022

PurposeThoracic aortic (TA) dilatation (TAD) is a risk factor for acute aortic syndrome and must therefore be reported in every CT report. However, the complex anatomy of the thoracic aorta impedes TAD detection. We investigated the performance of a deep learning (DL) prototype as a secondary reading tool built to measure TA diameters in a large-scale cohort.Material and methodsConsecutive contrast-enhanced (CE) and non-CE chest CT exams with “normal” TA diameters according to their radiology reports were included. The DL-prototype (AIRad, Siemens Healthineers, Germany) measured the TA at nine locations according to AHA guidelines. Dilatation was defined as &gt;45 mm at aortic sinus, sinotubular junction (STJ), ascending aorta (AA) and proximal arch and &gt;40 mm from mid arch to abdominal aorta. A cardiovascular radiologist reviewed all cases with TAD according to AIRad. Multivariable logistic regression (MLR) was used to identify factors (demographics and scan parameters) associated with TAD classification by AIRad.Results18,243 CT scans (45.7% female) were successfully analyzed by AIRad. Mean age was 62.3 ± 15.9 years and 12,092 (66.3%) were CE scans. AIRad confirmed normal diameters in 17,239 exams (94.5%) and reported TAD in 1,004/18,243 exams (5.5%). Review confirmed TAD classification in 452/1,004 exams (45.0%, 2.5% total), 552 cases were false-positive but identification was easily possible using visual outputs by AIRad. MLR revealed that the following factors were significantly associated with correct TAD classification by AIRad: TAD reported at AA [odds ratio (OR): 1.12, p &lt; 0.001] and STJ (OR: 1.09, p = 0.002), TAD found at &gt;1 location (OR: 1.42, p = 0.008), in CE exams (OR: 2.1–3.1, p &lt; 0.05), men (OR: 2.4, p = 0.003) and patients presenting with higher BMI (OR: 1.05, p = 0.01). Overall, 17,691/18,243 (97.0%) exams were correctly classified.ConclusionsAIRad correctly assessed the presence or absence of TAD in 17,691 exams (97%), including 452 cases with previously missed TAD independent from contrast protocol. These findings suggest its usefulness as a secondary reading tool by improving report quality and efficiency.
Net clinical benefit of antithrombotic therapy for atrial fibrillation patients with stable coronary artery disease
Authors: Lee So-Ryoung , Jung Jin-Hyung , Choi Eue-Keun , Lee Seung-Woo , Kwon Soonil , Park Ji-Suck , Kang Jeehoon , Han Kyung-Do , Park Kyung Woo , Oh Seil , Lip Gregory Y. H. 
Published: August 2022

ObjectivesTo compare the net clinical benefit of oral anticoagulant (OAC) monotherapy to OAC plus single antiplatelet therapy (SAPT) in patients with atrial fibrillation (AF) and stable coronary artery disease (CAD) at 1- and 3-year after percutaneous coronary intervention (PCI).BackgroundIt has not been studied whether the net clinical benefit of the antithrombotic treatment options differs depending on the elapsed time from the index PCI.MethodsUsing the Korean nationwide claims database, we included AF patients who underwent PCI from 2009 to 2019 and constructed two cohorts: 1- and 3-year after PCI. In each cohort, the baseline characteristics of two groups were balanced using propensity score weighting. Ischemic stroke, myocardial infarction, major bleeding, and composite clinical outcomes were analyzed.ResultsAmong patients with 1-year after PCI, OAC monotherapy (n = 678), and OAC plus SAPT (n = 3,159) showed comparable results for all clinical outcomes. In patients with 3-year after PCI, OAC monotherapy (n = 1,038) and OAC plus SAPT (n = 2,128) showed comparable results for ischemic stroke and myocardial infarction, but OAC monotherapy was associated with a lower risk of composite clinical outcomes (HR 0.762, 95% CI 0.607–0.950), mainly driven by the reduction of major bleeding risk (HR 0.498, 95% CI 0.345–0.701).ConclusionOral anticoagulant monotherapy may be a comparable choice for patients with AF and stable CAD compared to OAC plus SAPT. In patients with stable CAD more than 3-year after index PCI, OAC monotherapy would be a better choice, being associated with less major bleeding and a positive net clinical benefit.
Classification of seismic activity at the Lazufre Volcanic System, based on 2011 to 2012 data
Authors: McFarlin Heather , Thompson Glenn , McNutt Stephen R. , Braunmiller Jochen , West Michael E. 
Published: August 2022

The Lazufre Volcanic System (LVS), on the border of northern Chile and Argentina, is an active complex of two volcanoes, Lastarria to the north and Cordón del Azufre to the south. The LVS is not regularly monitored with any scientific equipment despite being recognized as a top ten volcanic hazard in Argentina by the Observatorio Argentino de Vigilancia Volcánica of the Servicio Geológico y Minero Argentino. The system has shown unusual inflation signatures observed in InSAR but the level of seismic activity and its spatial and temporal distribution were unknown due to the lack of a permanent local seismic network. The PLUTONS Project deployed eight broadband seismic stations throughout the LVS between November 2011 and March 2013. This study shows event locations and types from November 2011 through March 2012. We analyze 591 seismic events within 20 km of Lastarria. Most events cluster tightly beneath Lastarria and almost no activity is observed beneath Cordón del Azufre or the primary inflation center. All events are reviewed manually, and located using a velocity model that assimilates prior studies and accounts for hypocenters within the edifice up to 5 km above sea level. More than 90% of the resulting hypocenters are shallower than 10 km below sea level. The waveforms have characteristics similar to those observed at many other volcanoes, suggesting five classes of events: volcano-tectonic (VT), long-period 1 (LP1), long period 2 (LP2), hybrid (HY), and unknown (X). Frequency-magnitude analysis reveals distinct b-values ranging from 1.2 for VT events to 2.5 for LP1 events. Based on the spatial distribution of events and the b-values, we infer that seismic activity is driven mainly by movement of fluids and gases associated with the regional magma zones and inflation centers. The seismic activity is energetic at times, and quieter at others, suggesting the presence of episodic magmatic and/or hydrothermal activity, focused at Lastarria. Our findings indicate that the previously observed inflation signals are indeed volcanic in origin. These results also demonstrate the potential for success of a future seismic monitoring system and provide a framework for interpreting the subsequent observations, both of which are critical to assessing the volcanic risk of the northern Chile-Argentina region.