bluuebunny/crossref_metadata_2025_split huggingface dataset:
HOW TO EMPOWER ONLINE TEACHING: 12 PRINCIPLES FOR HIGHER AND POSTGRADUATE EDUCATION
Authors: Byrka Marian , Cherevko Igor , Yakubovska Nataliia , Shorobura Inna , Kurish Natalya 
Published: October 2022

The global pandemic COVID-19, which began in 2020, has brought about new challenges to Ukraine’s higher and postgraduate education institutions. Despite the previous experience of providing online education courses, one of the main challenges to these institutions now remains to perform effective online teaching, which requires a proper theoretical and instructional basis. The study aims to outline efficient online teaching principles and best practices of how online teaching can provide effective interaction in the virtual online classroom with the aid of online learning management systems, online educational technologies, and digital learning tools. The article suggests a framework of twelve principles of effective online teaching determined for higher and postgraduate education that is deployed at five levels grouped according to specific online teaching issues (Level 0. Lecturer readiness, Level 1. Course planning, Level 2. Students’ facilitation, Level 3. Course content dissemination, and Level 4. Course feedback). Each identified principle at every level is covered with examples of specific teaching methods and best practices of how it is used to enhance the effectiveness of online teaching in higher and postgraduate education. To perform most effectively in an online education context, every lecturer should use each level from the developed framework and each principle from the level. However, even a partial application of certain principles will increase the efficiency of the online teaching process. The suggested five-level framework of twelve principles will be helpful for lecturers, professors, and other academic staff of universities and institutes of higher and postgraduate education when providing online and distance education.
ВИКОРИСТАННЯ ПОТЕНЦІАЛУ СТУДЕНТСЬКОГО САМОВРЯДУВАННЯ У ФОРМУВАННІ ТА ПОГЛИБЛЕННІ ЦИФРОВОЇ КОМПЕТЕНОСТІ МАЙБУТНІХ ВЧИТЕЛІВ СПЕЦІАЛЬНОЇ ОСВІТИ
Authors: Мицик Ганна Михайлівна , Пришляк Михайло Іванович 
Published: October 2022

У статті досліджено роль студентського самоврядування у процесі формування та поглиблення цифрової компетентності майбутніх вчителів спеціальної освіти. Акцентовано увагу на актуальності використання інформаційно-комунікаційних технологій в освіті: наданні дистанційно корекційно-розвиткових послуг дітям з особливими освітніми потребами, забезпеченні підтримки інклюзивного навчання. Наведено результати онлайн опитування, якими підтверджена зацікавленість майбутніх вчителів спеціальної освіти у підвищенні рівня своєї цифрової компетентності. Висловлена думка щодо необхідності пошуку закладами вищої освіти нових підходів до оптимізації навчального процесу відповідно до сучасних вимог; дієвих способів її формування та поглиблення. Обґрунтована можливість використання в якості одного з інструментів формування та поглиблення цифрової компетентності майбутнього вчителя спеціальної освіти потенціалу студентського самоврядування. Викладене власне бачення автора щодо його вагомого місця у підтримці наскрізного характеру процесу формування та поглиблення цифрової компетентності майбутніх вчителів спеціальної освіти. Зазначено, що важливою в цьому контексті бачиться
творча співпраця органів студентського самоврядування та науково-педагогічних працівників кафедри закладу вищої освіти, що забезпечує підготовку майбутніх вчителів спеціальної освіти. Свого детального опису отримали форми участі студентського самоврядування у формуванні та поглибленні цифрової компетентності майбутніх вчителів спеціальної освіти. Запропоновано створення простору для неформальної освіти на рівні спеціальності 016 Спеціальна освіта – ЦифроХаб, з можливістю проведення в його рамках безкоштовних онлайн заходів з метою формування та поглиблення цифрової компетентності студентів в позанавчальний час. Деталізовано змістове наповнення івентів в авторській збірці «Handbook: керівництво з формування цифрової компетентності». Розроблено путівник з цифровими інструментами для початківців – «Guide для початківців: упевнений юзер у цифровому світі».
EFEKTIVITAS MODEL PEMBELAJARAN PROJECT BASED LEARNING (PJBL) BERBASIS STEMTERHADAP KETERAMPILAN BERPIKIR KRITIS SISWA
Authors: Aini Meliyana , Ridianingsih Dwi Swastanti , Yunitasari Indah 
Published: October 2022

Project Based Learniing merupakan salah satu model pembelajarn yang cocok diguanakan untuk siswa dibidang Sains. Model PjBL berbasis pendekatan STEM bertujuan untuk meningkatkan keterampiilan berpikir kritis siswa. Keterampilan berpikir kritis merupakan salah satu ketrampilan yang harus dimiliiki oleh siswa di Abad 21. Keterampilan ini membantu siswa dalam mengikuti tuntutan yang harus dicapai untuk mampu bersaing secara global. Metode yang digunakan mix method (kualitatif dan kuantitatif) dengan tujuan penelitian untuk mengidentfikasi efektivitas model PjBL berbasis STEM terhadap ketrampilan berpikir kritis siswa. Ketrampilan yang diukur berdasarkan 5 aspek keterampilan berpikir kritis, terdiri atas 12 indikator. Penelitian ini dilaksanakan pada siswa SMP kelas VIII. Pengumpulan data dengan tes. Hasil penlitian menunjukan ketrampilan berpikir kritis diperoleh sebesar 96,1% dengan kategori sangat baik.
ANALISIS KESALAHAN MAHASISWA PADA BENTUK KUTUB BILANGAN KOMPLEKS DITINJAU DARI KEMANDIRIAN BELAJAR
Authors: Utami Nida Sri 
Published: October 2022

Tujuan dari penelitian ini adalah menganalisis kesalahan mahasiswa pendidikan matematika semester keenam. Kesalahan yang diteliti adalah tentang mahasiswa matematika dalam menentukan bentuk kutub bilangan kompleks, pada materi analisis kompleks. Metode yang digunakan adalah deskriptif kualitatif. Subjek pada penelitian ini adalah mahasiswa pendidikan matematika semester empat di Universitas Muhammadiyah Surakarta tahun akademik 2021/2022. Data dalam penelitian ini diperoleh dengan tes, dan dokumentasi. Hasil penelitian menunjukkan bahwa mahasiswa dengan kemandirian belajar tinggi dan sedang tidak terdapat kesalahan membaca, kesalahan memahami, kesalahan transformasi, kesalahan keterampilan proses , dan kesalahan penulisan jawaban. Mahasiswa dengan kemandirian belajar rendah tidak terdapat kesalahan membaca, kesalahan memahami, kesalahan transformasi, namun ada kesalahan keterampilan proses, dan kesalahan penulisan jawaban
Reliability of using a pressure sensor system to measure in-water force in young competitive swimmers
Authors: Santos Catarina C. , Marinho Daniel A. , Costa Mário J. 
Published: October 2022

The aim of this study was to analyze the reliability of using a differential pressure system to measure in-water force in young competitive swimmers. Ten boys and five girls (12.38 ± 0.48 years, 49.13 ± 6.82 kg, 159.71 ± 7.99 cm) were randomly assigned to perform two maximum bouts of 25 m front crawl on different days (trial one, T1; trial two, T2), one week apart. A differential pressure system composed of two hand sensors (Aquanex System, v.4.1, Model DU2, Type A, Swimming Technology Research, Richmond, VA, United States) was used to measure the peak (RFPEAK) and the mean (RFMEAN) resultant force of the dominant and non-dominant hands (in Newton, N). Reliability was analyzed by computing the intraclass correlation coefficient (ICC), typical error (TE), smallest worthwhile change (SWC), coefficient of variation (CV%), standard error of measurement (SEM), and the minimal detectable change (MDC). Bland–Altman plots with 95% limits of agreement were also analyzed. The results showed no differences between T1 and T2 in all variables (p &gt; 0.05). The ICC showed “excellent” reliability (ICC &gt; 0.90) for the RFPEAK and RFMEAN in both hands. The CV% was rated as “good” (&lt;5%) and TE was smaller than SWC in all variables. The Bland-Altman plots showed high reliability with a small bias (RFPEAK dominant, -0.29 N; RFPEAK non-dominant, -0.83 N; RFMEAN dominant, 0.03 N; RFMEAN non-dominant, 0.50 N). The pressure sensor system (Aquanex System) seems to be a reliable device for measuring the hand resultant force during front crawl in young swimmers and can be used to monitor the changes over time.
A bibliometric analysis of PIN1 and cell death
Authors: Zhang Jia-Heng , Ni Shi-Yu , Tan Ya-Ting , Luo Jia , Wang Shu-Chao 
Published: October 2022

Background: Regulation of cell death plays a key role in numerous diseases. As a proline isomerase, prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is important for the regulation of signaling pathways. An in-depth understanding of how Pin1 participates in the process of cell death, which affects the occurrence and development of diseases, will aid in the discovery of new disease mechanisms and therapeutic methods. Thus, the purpose of our study was to discover the research trends and hotspots of Pin1 and cell death through bibliometric analyses and to provide insights for understanding the future development of basic research and treatment of diseases.Methods: Documents were extracted from the Web of Science Core Collection on 7 May 2022. We selected articles and reviews published in English from 2000 to 2021, and visual and statistical analyses of countries, institutions, authors, references and keywords were performed using VOSviewer 1.6.18 and CiteSpace 5.8.Results: A total of 395 articles and reviews were selected. Since 2001, the number of articles on Pin1 and cell death has increased annually. Publications come from 43 countries, with the US having the most publications and citations. We identified 510 authors, with Giannino Del Sal having the most articles and Paola Zacchi having the most co-citations. The Journal of Biological Chemistry is the most researched journal, and Nature and its subjournals are the most cited journals. Apoptosis, phosphorylation, and breast cancer were the three most common keywords.Conclusion: The number of documents showed an increasing trend from 2001 to 2014. Stagnant growth after 2014 may be related to the absence of new research hotspots. Cooperative links between core institutions need to be strengthened, and the institution with the highest citation count in recent years is Fujian Medical University in China. The role of Pin1 in cell death requires further research to discover new research hotspots. Before breakthroughs in molecular mechanism or signaling pathway research, future research will focus more on the treatment of diseases represented by Pin1 inhibitors.
Media and technology usage and attitudes in emergency department patients
Authors: Goldfine C. E. , Knapp A. , Goodman G. R. , Hasdianda M. A. , Huang H. , Marshall A. D. , Keschner Y. G. , Carreiro S. , Jambaulikar G. , Chai P. R. 
Published: October 2022

IntroductionDigital health technologies are increasingly being used in emergency medicine, many of which utilize smartphones and computers. Patient willingness to use these modalities is an important factor in successful implementation. Therefore, this study aimed to assess emergency department (ED) patients' use of and attitudes towards technology.MethodsThis was a pooled sub-analysis of ED patients (≥18 years old) that were enrolled in two studies evaluating the ED patient experience in response to novel technological interventions. Participants completed the Media and Technology Usage and Attitudes Scale (MTUAS) that assessed computer and smartphone ownership; frequency of use of phone calls, texting, email, and smartphones; and anxiety and dependence attitudes on these technologies.ResultsOne hundred and forty-four participants completed the survey. Mean age was 47.2 years (SD 17.94); 61.8% were female; and 61.1% were white. There was high usage of smartphones (93.1%) and computers (74.3%). Participants most frequently used phone calling and texting and least commonly used email. Participants had a positive attitude (mean 3.9/5, SD 0.68) towards the use of these technologies.DiscussionED patients reported high ownership of smartphones and computers, had a positive attitude towards their use, and had varying frequency with which they used different technologies. Future studies can use this information to inform the development of digital health interventions that utilize technologies that patients find most acceptable.
Severe impact of late diagnosis of congenital adrenal hyperplasia on gender identity, sexual orientation and function: case report and review of the literature
Authors: Simeoli Chiara , de Angelis Cristina , Delli Veneri Alessandra , Menafra Davide , Di Paola Nicola , Pivonello Claudia , Di Somma Carolina , Valerio Paolo , Melis Daniela , Alviggi Carlo , Colao Annamaria , Pivonello Rosario 
Published: October 2022

Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) represents the most frequent form of CAH and of 46, XX disorder of sex development in female newborns. In the majority of cases, particularly in developed countries, female patients suffering from the classic forms of CAH reach the diagnosis at birth or in the early childhood, allowing a prompt treatment with a correct gender assignment. The current manuscript describes an unusual case of an Italian 46-year-old woman, homeborn in the 60s, receiving an extraordinarily late diagnosis of simple virilising classic form of CAH due to 21-OHD, determining a relevant impairment of both physical and psychosexual development. The patient presented primary amenorrhea, height under target, overweight with visceral adiposity, hypercholesterolemia and insulin resistance, hirsutism with a typical male-pattern hair growth, external genital ambiguity, and a severe impairment in the entire series of psychological dimensions, particularly severe depressive symptoms, together with gender dysphoria relative to the female gender assigned at birth, cross-gender behaviours, and body image discomfort, which were associated with homosexual orientation, and sexual dysfunction. Following diagnosis and glucocorticoid (GC) replacement therapy, the hyperandrogenism control and familial and socio-cultural factors changes, particularly, living alone and the interruption of social isolation, were accompanied by menarche appearance, improvement in hirsutism and metabolic profile, and a resolution in all psychological dimensions, depressive symptoms, and gender dysphoria. The patient began to perceive homosexual orientation without discomfort, and ameliorating sexual function. Few cases of female patients with CAH due to 21-OHD receiving an extremely delayed diagnosis have been published. However, to the best of our knowledge, this is the first case including a complete psychosexual assessment at diagnosis with a detailed re-evaluation after 5 years of disease treatment.
Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on leukemia risk: An updated meta-analysis
Authors: Zhao Yan , Wang Di , Zhang Cheng-Yu , Liu Yan-Ju , Wang Xiao-Hui , Shi Meng-Ying , Wang Wei , Shen Xu-Liang , He Xiao-Feng 
Published: October 2022

Background: Several meta-analyses have analyzed the association of GSTM1 present/null, GSTT1 present/null, and GSTP1 IIe105Val polymorphisms with leukemia risk. However, the results of these meta-analyses have been conflicting. Moreover, they did not evaluate the combined effects of the three aforementioned gene polymorphisms. Furthermore, they did not appraise the credibility of the positive results. Finally, many new studies have been published. Therefore, an updated meta-analysis was conducted.Objectives: To further explore the relationship of the three aforementioned gene polymorphisms with leukemia risk.Methods: The crude odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the association of the individual and combined effects of the three aforementioned genes. Moreover, the false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP) were applied to verify the credibility of these statistically significant associations.Results: Overall, the individual GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms added leukemia risk. On combining GSTM1 and GSTT1, GSTM1 and GSTP1, and GSTT1 and GSTP1 polymorphisms, positive results were also observed. However, no significant association was observed between the combined effects of these three polymorphisms with leukemia risk in the overall analysis. Moreover, when only selecting Hardy–Weinberg equilibrium (HWE) and medium- and high-quality studies, we came to similar results. However, when the FPRP and BFDP values were applied to evaluate the credibility of positive results, the significant association was only observed for the GSTT1 null genotype with leukemia risk in Asians (BFDP = 0.367, FPRP = 0.009).Conclusion: This study strongly suggests a significant increase in the risk of leukemia in Asians for the GSTT1 null genotype.
Intimate intertwining of the pathogenesis of hypoxia and systemic sclerosis: A transcriptome integration analysis
Authors: He Xinglan , Shi Yaqian , Zeng Zhuotong , Tang Bingsi , Xiao Xuan , Yu Jiangfan , Zou Puyu , Liu Jiani , Xiao Yangfan , Luo Yangyang , Xiao Rong 
Published: October 2022

ObjectivesSystemic sclerosis (SSc) is an autoimmune disease caused by various pathogenic factors, including hypoxia. Hypoxia stimulates the production of the extracellular matrix to promote fibrosis. However, the integrated function and the underlying mechanism of hypoxia in SSc are unclear.MethodsIn the present study, we used Agilent SurePrint G3 Human Gene Expression v3 for the transcriptional sequencing of fibroblasts with and without hypoxia to detect differentially expressed genes (DEGs) in hypoxia. We analyzed the results with the transcriptome data of SSc lesions (GSE95065) to select the co-DEGs. Then, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed on the basis of the co-DEGs using the R package ClusterProfiler, which showed that hypoxia and cross talk of hypoxia with other pathogenic factors are involved in the pathogenesis of SSc. Furthermore, we constructed a protein–protein interaction (PPI) network of co-DEGs and screened two significant functional expression modules.ResultsWe identified nine hub genes (ALDH1A1, EGF, NOX4, LYN, DNTT, PTGS2, TKT, ACAA2, and ALDH3A1). These genes affect the pentose phosphate pathway, oxidative stress, and lipolysis.ConclusionOur study provides insights into the mechanisms underlying the effects of hypoxia on SSc pathogenesis, which will help to better understand SSc pathogenesis and develop new therapeutic strategies for SSc.
Effect of mean heart rate on 30-day mortality in ischemic stroke with atrial fibrillation: Data from the MIMIC-IV database
Authors: Yao Shao-li , Chen Xi-wen , Liu Jie , Chen Xiao-rong , Zhou Yao 
Published: October 2022

BackgroundThe relationship of mean heart rate (MHR) with 30-day mortality in ischemic stroke patients with atrial fibrillation in the intensive care unit (ICU) remains unknown. This study aimed to investigate the association between MHR within 24 h of admission to the ICU and 30-day mortality among patients with atrial fibrillation and ischemic stroke.MethodsThis retrospective cohort study used data on US adults from the Medical Information Mart for Intensive Care-IV (MIMIC-IV, version 1.0) database. Patients with ischemic stroke who had atrial fibrillation for and first time in ICU admission were identified from the MIMIC-IV database. We used multivariable Cox regression models, a restricted cubic spline model, and a two-piecewise Cox regression model to show the effect of the MHR within 24 h of ICU admission on 30-day mortality.ResultsA total of 1403 patients with ischemic stroke and atrial fibrillation (mean [SD] age, 75.9 [11.4] years; mean [SD] heart rate, 83.8[16.1] bpm; 743 [53.0%] females) were included. A total of 212 (15.1%) patients died within 30 days after ICU admission. When MHR was assessed in tertials according to the 25th and 50th percentiles, the risk of 30-day mortality was higher in participants in group 1 (&lt; 72 bpm; adjusted hazard ratio, 1.23; 95% CI, 0.79–1.91) and group 3 (≥82 bpm; adjusted hazard ratio, 1.77; 95% CI, 1.23–2.57) compared with those in group 2 (72–82 bpm). Consistently in the threshold analysis, for every 1-bpm increase in MHR, there was a 2.4% increase in 30-day mortality (adjusted HR, 1.024; 95% CI, 1.01–1.039) in those with MHR above 80 bpm. Based on these results, there was a J-shaped association between MHR and 30-day mortality in ischemic stroke patients with atrial fibrillation admitted to the ICU, with an inflection point at 80 bpm of MHR.ConclusionIn this retrospective cohort study, MHR within 24 h of admission was associated with 30-day mortality (nonlinear, J-shaped association) in patients with ischemic stroke and atrial fibrillation in the ICU, with an inflection point at about 80 bpm and a minimal risk observed at 72 to 81 bpm of MHR. This association was worthy of further investigation. If further confirmed, this association may provide a theoretical basis for formulating the target strategy of heart rate therapy for these patients.
Facial muscle movements in patients with Parkinson's disease undergoing phonation tests
Authors: Xu Fan , Zou Xian-wei , Yang Li-qiong , Mo Shi-cong , Guo Quan-hao , Zhang Jing , Weng Xiechuan , Xing Guo-gang 
Published: October 2022

PurposeParkinson's disease (PD) is a serious neurodegenerative disease affecting the elderly. In general, the locomotion deficit, which seriously affects the daily life of patients with PD, usually occurs at a later stage. The mask face symptom meanwhile progressively worsens. However, facial muscle disorders and changes involved in the freezing mask are unclear.MethodIn this study, we recruited 35 patients with PD and 26 age- and sex-balanced controls to undergo phonation tests, while the built-in camera on the laptop recorded their facial expressions during the whole pronunciation process. Furthermore, FaceReader (version 7.0; Noldus Information Technology, Wageningen, Netherlands) was used to analyze changes in PD facial landmark movement and region movement.ResultsThe two-tailed Student's t-test showed that the changes in facial landmark movement among 49 landmarks were significantly lower in patients with PD than in the control group (P &lt; 0.05). The data on facial region movement revealed that the eyes and upper lip of patients with PD differed significantly from those in the control group.ConclusionPatients with PD had defects in facial landmark movement and regional movement when producing a single syllable, double syllable, and multiple syllables, which may be related to reduced facial expressions in patients with PD.