bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indonesian Halal Pharmaceutical: Challenges And Market Opportunities
Authors: Herdiana Yedi , Rusdiana Taofik 
Published: June 2022

The halal food market has grown worldwide, including the shift from food to other products, including halal pharmaceuticals (HPC). The growth followed by the abundance of literature has been on halal, especially pharmaceuticals. Muslim consumers need halal certification (HCT) on medicines to ensure that they do not consume or use products or services that are not halal. The government must guarantee to Muslim consumers that consumer goods or services circulating in the community are truly halal. The halal label itself will increase consumer confidence, expand the reach of the global halal food market, and increase the marketability of products in the market. Indonesia, which is predominantly Muslim, is considered a long extension in implementing HP until 2034. Different attitudes are shown by several countries with large non-Muslim majority populations but are very concerned about the implementation of HPC. The accelerated growth of knowledge of halalness, impact social media, will push the industry to implement HPC. In this review, we will discuss critical players in implementing HPC, including the ingredients that have been widely used but still doubt their halalness and what they are used for in the pharmaceutical industry. This knowledge is essential for industry and researchers to build safer alternative materials.Keywords: Halal, Indonesia, Muslim, Halal Pharmaceutical, Halal Certification.
Is combined physical therapy more effective than topical hyperbaric oxygen therapy in the treatment of venous leg ulcers? Preliminary study
Authors: Pietrzak Mikołaj , Pasek Jarosław , Szajkowski Sebastian , Szyluk Karol , Cieślar Grzegorz 
Published: June 2022

Abstract

Introduction
Recently, increased frequency of chronic leg ulcers has been observed. The aim of the study was to compare therapeutic efficacy of combined physical therapy to topical hyperbaric oxygen therapy in the treatment of venous leg ulcers.

Materials and Methods
Participants included 36 patients (14 females and 22 males) between 18 and 80 years of age with chronic venous leg ulcers. They were randomly divided into two study groups. Group I underwent topical hyperbaric oxygen therapy; group II underwent combined physical therapy. Before and after the therapeutic cycle (15 procedures) measurement of ulceration size by planimetry and analysis of laboratory parameters of blood was performed.

Results
In both groups, a statistically significant reduction of ulcer surface area was obtained (25.11±17.8cm2 to 16.93±13.89cm2, p=0.000196) vs. (34.17±14.82cm2 to 23.99±15.15cm2, p=0.004337). Blood morphology revealed a statistically significant reduction in patients from group II who underwent combined physical therapy (p=0.01). In both groups, statistically significant reduction of fibrinogen level (p=0.01 and p<0.001), and total protein level (p=0.01) was achieved. In group II reduction of the inflammation marker C-reactive protein (CRP) was noted.

Conclusions
Topical hyperbaric oxygen therapy and combined physical therapy had statistically significant effects on the reduction of surface area of treated venous leg ulcers. The changes in morphological and biochemical parameters may indicate the anti-inflammatory and anti-clotting action effects of combined physical therapy.
Frequencies of the MEFV Gene Mutations in Azerbaijan
Authors: Huseynova LS , Mammadova SN , Aliyeva KAA 
Published: June 2022

Abstract
The MEFV (familial Mediterranean fever gene) researches were performed in the population of the Republic of Azerbaijan in 2016–2021. Seven mutations of the MEFV gene were identified in heterozygous, homozygous and compound homozygous conditions: R761H, M694I, M694V, V726A, R202Q, M680I and E148Q. The E148Q and R202Q mutations were discovered in exon 2 and R761H M694I, M694V, V726A, M680I were found in exon 10 in the population of the Republic of Azerbaijan. The highest gene frequency of the MEFV gene examined in 42 patients was 42.85% in the M694V mutations. The second highest frequency was the R761H and the third most frequent mutation was V726A. According to world literature, five mutations, M694V, V726A, M694I, R202Q, M680I and E148Q, constitute 75.0% of all mutations found today. In our studies, these five mutations belong to the same group, and makes up 57.6% of the total mutations found. In order to prevent hereditary disease such as the familial Mediterranean fever (FMF) in the population of the Republic of Azerbaijan, it is planned to carry out prenatal diagnosis (PND) of the at-risk families.
Risk Factors of Venous Thromboembolism in Sudanese Pregnant Women
Authors: Abdalhabib EK , Alfeel A , Ali EI , Ibrahim IK , Mobarki AA , Dobie G , Hamali HA , Saboor M 
Published: June 2022

Abstract
Venous thromboembolism (VTE) is one of the major causes of pregnancy-related mortality and morbidity. This study aimed to determine the frequency of factor V Leiden (FVL) and prothrombin G20210A polymorphisms and measure the plasma levels of protein C (PC), protein S (PS) and antithrombin (AT) in pregnant women with VTE and healthy pregnant women. This prospective case-control study determined the frequencies of FVL G1691A and prothrombin G20210A polymorphisms and measured the plasma levels of PC, PS and AT in 198 pregnant women with VTE and 198 healthy pregnant women. Allele-specific polymerase chain reaction (ASPCR) was used to detect the FVL G1691A polymorphisms and prothrombin G20210A gene mutations. The FVL G1691A polymorphism and prothrombin G20210A gene mutations were detected only in pregnant women with VTE, with frequencies of 4.0 and 0.5%, respectively. The highest frequency of FVL G1691A polymorphism was observed in patients with deep vein thrombosis (DVT) and positively associated with contraceptive use and termination. Pregnant women with VTE had significantly lower levels of PC, PS and AT than those of controls. In conclusion, among the VTE cases, FVL G1691A polymorphism and PC, PS and AT deficiencies were the most common findings in patients presenting with DVT. Antithrombin deficiency was more common than PC and PS deficiencies. Contraceptive use, high body mass index (BMI) and termination correlated strongly with FVL G1691A polymorphism and PC and PS deficiencies in patients with VTE.
Clinical Experience of Neurological Mitochondrial Diseases in Children and Adults: A Single-Center Study
Authors: Rogac M , Neubauer D , Leonardis L , Pecaric N , Meznaric M , Maver A , Sperl W , Garavaglia BM , Lamantea E , Peterlin B 
Published: June 2022

Abstract
The goal of the study was to retrospectively evaluate a cohort of children and adults with mitochondrial diseases (MDs) in a single-center experience. Neurological clinical examination, brain magnetic resonance imaging (MRI) and spectroscopy, muscle biopsy, metabolic and molecular-genetic analysis were evaluated in 26 children and 36 adult patients with MD in Slovenia from 2004 to 2018. Nijmegen MD criteria (MDC) were applied to all patients and the need for a muscle biopsy was estimated. Exome-sequencing was used in half of the patients. Twenty children (77.0%) and 12 adults (35.0%) scored a total of ≥8 on MDC, a result that is compatible with the diagnosis of definite MD. Yield of exome-sequencing was 7/22 (31.0%), but the method was not applied systematically in all patients from the beginning of diagnostics. Brain MRI morphological changes, which can be an imaging clue for the diagnosis of MD, were found in 17/24 children (71.0%). In 7/26 (29.0%) children, and in 20/30 (67.0%) adults, abnormal mitochondria were found on electron microscopy (EM) and ragged-red fibers were found in 16/30 (53.0%) adults. Respiratory chain enzymes (RCEs) and/or pyruvate dehydrogenase complex (PDHc) activities were abnormal in all the children and six adult cases. First, our data revealed that MDC was useful in the clinical diagnosis of MD, and second, until the use of NGS methods, extensive, laborious and invasive diagnostic procedures were performed to reach a final diagnosis. In patients with suspected MD, there is a need to prioritize molecular diagnosis with the more modern next-generation sequencing (NGS) method.
Targeted microRNA Profiling in Gastric Cancer with Clinical Assessement
Authors: Pehlevan Özel H , Dinç T , Tiryaki RS , Keşküş AG , Konu Ö , Kayilioğlu SI , Coşkun F 
Published: June 2022

Abstract
Although several microRNAs (miRNAs) have been associated with gastric cancer there is still the need for identification of stable and validated biomarkers. The purpose of this study was to determine the alterations of a specific set of miRNA levels in gastric adenocarcinoma tissues to identify and validate gastric cancer-specific miRNAs using paired normal and tumor samples in an independent patient cohort. Gastric adenocarcinoma and normal stomach tissue samples of 20 patients who underwent surgery for gastric cancer were studied. The miRNA expression profiling was performed for eight miRNAs in a total of 40 tissue samples using quantitative reverse transcription polymerase chain reaction (RT-qPCR). Six out of these eight miRNAs, namely, miR-375-3p, hsamiR-129-5p, miR-196a-5p, miR-376c-3p, miR-34c-5p and miR-767-5p, were significantly underexpressed in malignant tissues of our cohort. Furthermore, the expression of miR-662 although not significantly different between normal and tumor tissues, was inversely associated with age (r = −0.440, p = 0.049). The levels of miR-129-3p and miR34c-5p were correlated with an increase in the number of metastatic lymph nodes (r = 0.470, p = 0.036; r = 0.510, p = 0.020), while and miR-376c-3p levels were negatively associated with smoking (p = 0.043). In addition, we found that the variability of miRNA expression in cancerous tissues was lower than that in normal tissues. Alterations in miRNA expression in gastric adenocarcinoma tissues in comparison to healthy tissues of each individual serves for identification of consistent biomarkers that can be used for development of diagnostic tools for gastric cancer.
Determination of Cystic Fibrosis Mutation Frequency in Preterm and Term Neonates with Respiratory Tract Problems
Authors: Tanriverdi S , Polat M , Onay H 
Published: June 2022

Abstract
Cystic fibrosis (CF) is an autosomal recessive disease. The genetic transition occurs with CF transmembrane conductance regulator (CFTR) gene mutation. We aimed to determine the frequency of CF mutations and also new mutations in the CFTR gene in neonates with respiratory distress. Newborn babies hospitalized due to respiratory distress were included in the patient group. The control group consisted of infants who had no respiratory distress. The CFTR genes of both groups were analyzed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. A total of 40 patients (20 in the patient group and 20 in the control group) were evaluated. The CFTR gene analysis was normal in 16 neonates in the patient group, whereas in others: A46D (c.137C>A) (n = 1), D1312G (c.3935A>G) (n = 1), R117H (c.350G>A) (n = 1), S1426P (c.4276T>C) (n = 1) heterozygotes were detected; CFTR gene analysis was normal at 14 neonates in the control group, whereas in others: E1228G (c.3683A>G) (n = 1), E217G (c.650A>G) (n = 1), E632TfsX9 (c1894_1895delAG) (n = 1), I807M (c.2421 A>G) (n = 2), S573F (c.1718C>T) (n = 1) heterozygotes were detected. There was no significant difference in the patient and control groups’ CFTR gene analysis (p = 0.340). This study demonstrates the importance of CFTR gene analysis in asymptomatic newborn infants for follow-up and early diagnosis of CFTR-related disorders. In this study, a c.1894_1895delAG (E632TfsX9) heterozygous mutation detected in the CFTR gene in an asymptomatic newborn infant, was first encountered in the literature.
Novel GPC3 Gene Mutation in Simpson-Golabi-Behmel Syndrome with Endocrine Anomalies: A Case Report
Authors: Bu W , Zhu M , Li S , Liu H , Liu X 
Published: June 2022

Abstract
Simpson-Golabi-Behmel syndrome (SGBS) represents a rare X-linked recessive syndrome with prenatal and postnatal overgrowth, coarse facial features, congenital malformations, organomegaly and an increased risk of tumors. Mutations on the GPC3 gene, encoding the glypican-3 protein, have previously been shown to cause the disease. In this report, a 12-year-old Chinese boy was hospitalized in our institution for some clinical features of SGBS. His serum endocrine evaluation showed hormone level abnormalities, including high prolactin, high testosterone, high thyroid-stimulating hormone (TSH) levels, and low estradiol levels. Whole exome sequencing (WES) was performed in the patient for mutation analysis and a novel hemizygous mutation, c.185delT, p.(Leu62Cysfs*22), on the GPC3 gene, was identified. The mother was a heterozygous carrier. The SGBS patients might present with endocrine anomalies, which adds to the clinical heterogeneity of the disease. The novel GPC3 mutation c.185delT expands the mutational spectrum of the GPC3 gene.
International Teacher Identity Construction: A Story of An Afghan International Student
Authors: Budianto Lestari 
Published: June 2022

Foreign language plays important role in constructing a new identity for an international student. This paper explored the role of English for an international student studying in an Indonesian institute in constructing a new identity as an international teacher in Indonesia. This research used qualitative as the method and narrative inquiry became the research design. The participant of this research was an Afghan international student pursuing a master's degree in an Indonesian institute. The data were obtained through semi-structured interviews and documentation. The findings of this research showed that English skills were needed to show that the participant was an international teacher and English was beneficial for the participant in constructing a new identity as an international teacher in Indonesia. The participant had started learning English in his Junior High School and practiced using it intensively when the participant went abroad to continue his study for bachelor’s and master’s degrees. This research also revealed that having good speaking skills opened an opportunity for the participant to apply for a job as an English international teacher in Indonesia. Moreover, the speaking skills and international English teacher identity created a bridge for the participant to be a speaker for some events such as seminars and English-based events held by schools and institutes. This research was limited to a participant from a country and focused on teacher identity. It is suggested for future research to conduct similar research with more various participants from various countries and focus on another kind of identity construction.
LAYANAN BIMBINGAN KLASIKAL SECARA ONLINE DALAM MENGATASI KEJENUHAN BELAJAR SELAMA PANDEMI COVID-19
Authors: AFRNM Aldila Fitri Radite Nur Maynawati , Monika Ayu Nurhayati  , Yuraida Ita Kurniawati  
Published: June 2022

Penelitian ini dilatarbelakangi oleh adanya peserta didik yang mengalami kejenuhan dalam belajar. Penelitian ini bertujuan untuk mendiskripsikan kejenuhan belajar melalui layanan bimbingan klasikal pada peserta didik di SMA Negeri 3 Sukoharjo. Proses pemberian layanan diberikan kepada peserta didik secara online dengan mematuhi kebijakan pemerintah dalam masa pandemic COVID-19. Namun, dalam pelaksanaan pembelajaran nemui banyak kendala, mulai dari kendala signal, hingga kuota internet yang terjadi dalam proses belajar daring. Namun, tidak semua peserta didik mengalami kendala tersebut ada peserta didik yang dapat mengikuti proses pembelajaran dari awal hingga selesai. Penelitian ini dimaksudkan untuk mengetahui kejenuhan belajar, hingga cara mengatasi kejenuhan belajar pada peserta didik. Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif penanganan kasus bermaksud agar dapat membantu mengatasi kejenuhan belajar pada peserta didik di SMA Negeri 3 Sukoharjo. Hasil penelitian ini memperlihatkan banwa peserta didik mengalami kejenuhan belajar kerena adanya kelelahan emosional yang terjadi secara berulang-ulang dalam jangaka waktu yang panjang.
TRACKING TRANSAKSI PORTOFOLIO ASET INVESTASI SAHAM PERHITUNGAN AVERAGE PRICE
Authors: Mulyawan Bagus , Lauro Manatap Dolok , Toni Agus 
Published: June 2022

Pantau portofolio investasi saham besar di beberapa platform investasi yang berbeda. Sulitnya pemantauan aset tetap membuat sulitnya menentukan rata-rata dan nilai akhir dari suatu portofolio investasi saham, yang berdampak pada ketidaktepatan keputusan investasi. Oleh karena itu, diperlukan suatu sistem yang dapat membantu investor dalam memilih jenis produk keuangan dengan menghitung return dan risiko yang diharapkan serta memantau portofolio investasinya sehingga dapat mengambil keputusan investasi yang tepat. Metode yang digunakan untuk menentukan nilai harga saham adalah metode Weighted Average, yang mempertahankan validasi pedoman perdagangan investasi. Kerugian pada saat berinvestasi dalam suatu kebijakan investasi saham diminimalkan sehingga hasil dari portofolio investasi saham tersedia dalam bentuk nasabah atau sebagai total nasabah. Aplikasi ini membantu pedagang swasta menemukan catatan keuangan lebih efisien dan meningkatkan, dan menemukan kerugian dan keuntungan dalam transaksi investasi saham. Aplikasi ini memungkinkan Anda untuk melihat banyak pelanggan secara bersamaan, tidak hanya satu pelanggan, tentang harga rata-rata jual beli. Hasil akhir yang ditampilkan dalam aplikasi akan berupa laporan Excel.
PERANCANGAN SISTEM PEMASARAN ONLINE BERBASIS ANDROID PADA PT.BINTANG KAMILLO PROPERTY
Authors: Cashiragi Robby 
Published: June 2022

Seiring dengan perkembangan zaman,teknologi yang ada pada saat ini semakin canggih dan membuat segala sesuatu menjadi instan atau serba cepat dan akurat.Dengan adanya teknologi ini semua dapat dikerjakan dengan online.Maka dari itu Smartphone bisa menjadi salah satu jembatan untuk pemasaran perumahan saat ini yang dimana pelanggan tidak perlu keluar rumah untuk melihat detail rumah tersebut. Dengan adanya hal tersebut terbentuklah bintang kamillo application ini. Bintang kamillo application ini dibuat dengan tujuan agar pelanggan dapat melihat detail rumah serta dapat menjual property mereka secara online.dan untuk pembuatan aplikasi ini digunakan,php dan android studio sebagai bahasa pemogramannya,dan mysql sebagai database dari aplikasi tersebut.dalam aplikasi ini juga terdapat sistem untuk meninput,update,delete data yang ada pada database tersebut sehingga dapat mempermudah perusahaan untuk data-data yang mereka perlukan. Dalam aplikasi ini terdapat tiga user yaitu Customer,Marketing,dan Admin. Dimana Admin dapat melakukan input,update,dan delete data sedangkan Marketing dapat melakukan validasi data property dan membuat perjanjian dan Customer bisa melihat daftar rumah,detail rumah,menjual rumah ataupun booking rumah yang tersedia.
APLIKASI PENJUALAN PRODUK KECANTIKAN PADA PT. SINERGI GLOBAL SERVIS BERBASIS ANDROID
Authors: Chandra Jett Enrico , Rusdi Zyad , Lauro Manatap Dolok 
Published: June 2022

Due to the pandemic, government were releasing a new rule about the restrictions that people could not go to public places like restaurants, shops, etc. It causes the sales on the PT. Sinergi Global Servis (SGS) since the beginning of the pandemic getting worse.Therefore I would love to help SGS and people that are loyal to the Martha Tilaar Group’s products to build an mobile-based application since they cannot visit and buy the product at the nearest store.For the development I used SDLC (System Development Life Cycle) method, with Waterfall model, I also used Flutter as the Framework for the programming, Dart Programming Language, MySQL for the Database, and lastly PHP for the API (Application Programming Interface) that used for sending data from database to application.The application’s feature that I build were customers can search the catalogue’s product, make an order, review a product, etc. Then the orders that was made by a customer, it went to the sales’s account and they could proceed the orders, the company also have an account and they could see transaction,absence, and stock reports.
Tracking Aktivitas Manusia Dalam Ruangan Menggunakan Kalman Filter
Authors: Jessica Jessica , Lina Lina 
Published: June 2022

With the increase of many households using surveillance systems for security, unlike office and mall buildings which own security human resources, house owners make time to manually check security footages. This gives house owners inconvenience and owning a security system seems more tedious, therefore inefficient if the footage is rarely seen. AI makes it possible to automatically check security footages. Using footage taken from a special room in home, susceptible for security breach and strategic, for example living room. This App works as a tool for homeowners, giving information about indoor activity. Information is given in a form of video footage of human tracking results containing trajectory line and activity log. Hence home owners will be able to supervise certain rooms and human behavior. Adopting point tracking as a detecting method, the target object is detected using background subtraction and image preprocessing to obtain centroid point, an input for statistical prediction of Kalman filter. Testing results showed that RMSE of Kalman filter prediction is higher than background subtraction when compared to true location, therefore background subtraction is used for Kalman filter’s RMSE. Resulting in RMSE for two scenarios are 85,08 and 89,28, this app also shows overall accuracy of 65,43%, precision of 70,56% and recall of 63,18% in total.
PEMBUATAN GAME 2D ONLINE CROSS-PLAY MULTIPLAYER CO-OP PLATFORMER “SHAPE SURVIVOR”
Authors: Sunarjo Jonathan , Pragantha Jeanny , Haris Darius Andana 
Published: June 2022

This game was created using the Unity game engine with C# as programming language. The goal of this game is to complete stages by playing cooperatively with 2 to 4 players. At each stage players will have to dodge various enemy attack to survive and clear the stage. Testing is done by blackbox testing, alpha testing by the supervisor, and beta testing by 32 respondents through a questionnaire. The test results show that players enjoy the multiplayer aspect and have fun with the game.
SISTEM INFORMASI JASA FOTO COPY DAN PRINT SECARA ONLINE BERBASIS WEB
Authors: Ishak Refindo 
Published: June 2022

Web-based online photocopy and print services are photocopy and print services that can be used via websites and smartphones and can be delivered by online motorcycle taxi services so that customers or service users do not need to come to the service place, in the process of developing a photo copy system and print is still manual, therefore the author wants to make a computerized online photocopy and print service. The WEB languages used are php and mysql as the database and uses the SDLC methodology by Dennis Barbara and Roberta (2012)
MARKETPLACE CHINESE FOOD DENGAN SISTEM REKOMENDASI MENGGUNAKAN ITEM-BASED COLLABORATIVE FILTERING
Authors: Yanto Yanto , Herwindiati Dyah Erny , Lauro Manatap Dolok 
Published: June 2022

Chinese food (typical Chinese cuisine) which is one of the most popular foods in the world. Almost all over the earth, there are always residing Chinese restaurants. Along with the development of culinary in Indonesia, Chinese food restaurant owners began to carry out certain specifications on the menus on offer. As customers will definitely be confused in the choice of food, when the Restaurants have more than one menu. Therefore we need a Marketplace with a recommendation system with the Item-based Collaborative Filtering method. Marketplace is an inter-organizational information system where buyers and sellers in the market communicate information about prices, products and are able to complete transactions via electronic communication channels. There are several stages in using this method, based on first assessing the data, then entering the calculation phase of the similarity between items and then calculating the prediction of item ratings for users.