bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic potential of novel biomarkers of hypertension in men
Authors: Charkiewicz Angelika , Garley Marzena , Ratajczak-Wrona Wioletta , Jabłońska Ewa , Miltyk Wojciech , Motyka Joanna , Omeljaniuk Wioleta 
Published: November 2022

IntroductionThe present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies.Material and methodsWe present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, hypertension and coexisting coronary artery disease.ResultsElevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, with elevated level of NCF2.ConclusionsPCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension.
MiRNA-21 promotes differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells by regulating the Ajuba/Isl1 axis pathway
Authors: Yang Wengang , Zhao Lei , Xue Song , Liu Jidong , Shan Jianggui 
Published: November 2022

IntroductionIn this study, we aimed to investigate the role of miRNA-21 and the regulating pathway that promotes the differentiation of bone marrow mesenchymal stem cells (BMSCs).Material and methodsWe used miR-21-OE, miR-21-KD, ajuba-OE and ajuba-KD plasmids to infect BMSCs. The expression of miRNA-21, ajuba, Isl1 and cTnI was detected by RT-qPCR, WB and immunofluorescence staining in groups.ResultsMiRNA-21 over-expression increased the expression of Isl1, and vice versa. Ajuba over-expression decreased the expression of Isl1, and vice versa. Ajuba negatively regulated the differentiation of BMSCs into cardiomyocyte-like cells.ConclusionsMiRNA-21 could regulate differentiation of bone marrow mesenchymal stem cells (BMSCs) to cardiomyocyte-like cells through the ajuba/Isl1 axis pathway.
EVALUASI PENGGUNAAN OBAT PADA PASIEN GASTROESOPHAGEAL REFLUX DISEASE (GERD) RAWAT JALAN DI RUMAH SAKIT UMUM PURBOWANGI GOMBONG PERIODE TAHUN 2019-2020
Authors: Marsiyah Animei 
Published: November 2022

Latar Belakang : Gastroesophageal Reflux Disease (GERD) merupakan salah satu penyakit saluran pencernaan yang menyerang lambung, yang diakibatkan karena kembalinya isi dari lambung yang masuk dalam kerongkongan, dengan berbagai tanda dan gejala seperti Heartburn dan Regurgitasi. Penyakit ini sering dianggap penyakit yang normal, namun penyakit ini dapat menyebabkan kekambuhan sampai dengan kematian, dimana jika hal ini dibiarkan akan menyebabkan keparahan dan pada akhirnya asam lambung akan terluka dan terjadi ulkus sehingga akan menyebabkan muntah darah. Salah satu tatalaksana penyakit ini yaitu dengan pemberian obat golongan H2RA, Antasida, Sucralfat dan PPI yang penggunaannya perlu dievaluasi untuk menjamin mutu dan efektivitas terapi Gastroesophageal Reflux Disease (GERD) yang meliputi tepat indikasi, tepat pasien, tepat obat dan tepat dosis (4 T).
Tujuan Penelitian : Mengetahui ketepatan penggunaan obat pada pasien Gastroesophageal Reflux Disease (GERD) rawat jalan di Rumah Sakit Umum Purbowangi Gombong yang ditinjau dari aspek tepat indikasi, tepat obat, tepat pasien dan tepat dosis.
Metode Penelitian : Penelitian non eksperimental dengan pengambilan data secara retrospektif, teknik pengambilan sampel total sampling dan dianalisis secara deskriptif.
Hasil Penelitian : Dalam penelitian ini diperoleh 81 kasus Gastroesophageal Reflux Disease (GERD). Data yang dihasilkan kemudian dibandingkan dengan Koda Kimble 2013. Didapatkan hasil 100% tepat indikasi, 95% tepat pasien, 85% tepat obat dan 33% tepat dosis di Rumah Sakit Umum Purbowangi Gombong periode tahun 2019-2020..
Kesimpulan : Evaluasi penggunaan obat untuk menangani Gastroesophageal Reflux Disease (GERD) diketahui bahwa sudah tepat indikasi, tepat pasien, tepat obat dan tepat dosis sesuai dengan Koda Kimble 2013.
Interannual global carbon cycle variations linked to atmospheric circulation variability
Authors: Li Na , Sippel Sebastian , Winkler Alexander J. , Mahecha Miguel D. , Reichstein Markus , Bastos Ana 
Published: November 2022

Abstract. One of the least understood temporal scales of global carbon cycle (C-cycle) dynamics is its interannual variability (IAV). This variability is mainly driven by variations in the local climatic drivers of terrestrial ecosystem activity, which in turn are controlled by large-scale modes of atmospheric variability. Here, we quantify the fraction of global C-cycle IAV that is explained by large-scale atmospheric circulation variability, which is quantified by spatiotemporal sea level pressure (SLP) fields. C-cycle variability is diagnosed from the global detrended atmospheric CO2 growth rate and the land CO2 sink from 16 dynamic global vegetation models and two atmospheric inversions in the Global Carbon Budget 2018. We use a regularized linear regression model, which represents a statistical learning technique apt to deal with the large number of atmospheric circulation predictors (p≥800, each representing one pixel-based time series of SLP anomalies) in a relatively short observed record (n<60 years). We show that boreal winter and spring SLP anomalies allow predicting IAV in the atmospheric CO2 growth rate and the global land sink, with Pearson correlations between reference and predicted values between 0.70 and 0.84 for boreal winter SLP anomalies. This is comparable to or higher than that of a similar model using 15 traditional teleconnection indices as predictors. The spatial patterns of regression coefficients of the model based on SLP fields show a predominant role of the tropical Pacific and over Southeast Asia extending to Australia, corresponding to the regions associated with the El Niño–Southern Oscillation variability. We also identify another important region in the western Pacific, roughly corresponding to the West Pacific pattern. We further evaluate the influence of the time series length on the predictability of IAV and find that reliable estimates of global C-cycle IAV can be obtained from records of 30–54 years. For shorter time series (n<30 years), however, our results show that conclusions about CO2 IAV patterns and drivers need to be evaluated with caution.
Overall, our study illustrates a new data-driven and flexible approach to model the relationship between large-scale atmospheric circulation variations and C-cycle variability at global and regional scales, complementing the traditional use of teleconnection indices.
Geologic and geodetic constraints on the magnitude and frequency of earthquakes along Malawi's active faults: the Malawi Seismogenic Source Model (MSSM)
Authors: Williams Jack N. , Wedmore Luke N. J. , Fagereng Åke , Werner Maximilian J. , Mdala Hassan , Shillington Donna J. , Scholz Christopher A. , Kolawole Folarin , Wright Lachlan J. M. , Biggs Juliet , Dulanya Zuze , Mphepo Felix , Chindandali Patrick 
Published: November 2022

Abstract. Active fault data are commonly used in seismic hazard assessments,
but there are challenges in deriving the slip rate, geometry, and frequency
of earthquakes along active faults. Herein, we present the open-access
geospatial Malawi Seismogenic Source Model (MSSM; https://doi.org/10.5281/zenodo.5599616), which describes the seismogenic properties of faults that formed during ongoing east African rifting in Malawi. We first use empirically derived constraints to geometrically classify active faults into section, fault, and multifault seismogenic sources. For sources in the North Basin of Lake Malawi, slip rates can be derived from the vertical offset of a seismic reflector that dated lake cores indicate is 75 ka. Elsewhere, slip rates are constrained from advancing a systems-based approach that partitions geodetically derived rift extension rates in Malawi between seismogenic sources using a priori constraints on a regional strain distribution and a hanging wall flexural extension in magma-poor continental rifts. Slip rates are then combined with source geometry and empirical scaling relationships to estimate earthquake magnitudes and recurrence intervals, and their uncertainty is described from the variability in logic tree outcomes used in these calculations. Sources in the MSSM are 5–269 km long, which implies that large-magnitude (Mw 7–8) earthquakes may occur in Malawi. However, low slip rates (0.05–2 mm yr−1) mean that the frequency of such events will be low (recurrence intervals of ∼103–104 years). We also find that, for 9 out of 11 faults in Lake Malawi's North Basin, differences in the slip rates, when estimated independently from the geodetic data and the offset seismic
reflector, are not statistically significant. The MSSM represents an important resource for investigating Malawi's increasing seismic risk and
provides a framework for incorporating active fault data into seismic hazard assessment elsewhere in the East African Rift and other tectonically active regions.
Multiple limit cycle amplitudes in high-fidelity predictions of standstill wind turbine blade vibrations
Authors: Grinderslev Christian , Nørmark Sørensen Niels , Raimund Pirrung Georg , González Horcas Sergio 
Published: November 2022

Abstract. In this study, vortex-induced vibrations (VIVs) on the IEA 10 MW blade are investigated using two methodologies in order to assess strengths and weaknesses of the two simulation types.
Both fully coupled fluid–structure interaction (FSI) simulations and computational fluid dynamics (CFD) with forced motion of the blade are used and compared. It is found that for the studied cases with high inclination angles, the forced-motion simulations succeed in capturing the power injection by the aerodynamics, despite the motion being simplified.
From the fully coupled simulations, a dependency on initial conditions of the vibrations was found, showing that cases which are stable if unperturbed might go into large VIVs if provoked initially by, for instance, inflow turbulence or turbine operations. Depending on the initial vibration amplitudes, multiple limit cycle levels can be triggered, for the same flow case, due to the non-linearity of the aerodynamics.
By fitting a simple damping model for the specific blade and mode shape from FSI simulations, it is also demonstrated that the equilibrium limit cycle amplitudes between power injection and dissipation can be estimated using forced-motion simulations, even for the multiple stable vibration cases, with good agreement with fully coupled simulations.
Finally, a time series generation from forced-motion simulations and the simple damping model is presented, concluding that CFD amplitude sweeps can estimate not only the final limit cycle oscillation amplitude, but also the vibration build-up time series.
PENATALAKSANAAN FISIOTERAPI PADA KASUS OSTEOARHTRITIS GENU DEXTRA DENGAN METODE KINESIOTAPPING, HOLD RELAX STREATCHING DAN MODALITAS US
Authors: Yuri Salshabila Adinda , Hadi Putra , Faridah Faridah 
Published: November 2022

ABSTRAK
Latar Belakang : Osteoarhtritis (OA) salah satu kondisi patologi yang sering terlihat pada lansia. osteoarhtritis lutut salah satu penyebab gangguan muskuloskeletal dan gangguan degeneratif sendi yang paling banyak ditemui, akibat dari penyakit ini pada lansia adalah nyeri kronis pada persendian tubuh, problematik pada osteoarhtritis lutut sangat komplek karena adanya abrasi tulang rawan sendi dan pembentukan tulang baru pada permukaan persendian yang mampu menyebabkan kelemahan otot sehingga membatasi gerak dan menyebabkan nyeri. Penyakit degeneratif pada lutut dapat menyebabkan permukaan sendi lutut menjadi tidak teratur dan kasar, ini akan menyebabkan rasa sakit dan bengkak pada lutut. Penelitian ini bertujuan untuk mengetahui penatalaksanaan metode kinesiotapping, hold relax streatching dan modalitas us phonoporesis dalam menurunkan nyeri, meningkatkan kekuatan otot dan lingkup gerak sendi (LGS) pada kasus osteoarhtritis. Metode yang digunakan adalah metode studi kasus dengan 1 orang responden menggunakan alat ukur VAS untuk mengukur nyeri, MMT untuk mengukur kekuatan otot dan goneometer untuk mengukur LGS. Hasil dari penelitian yang dilakukan di Kecamatan Kota Baru, Kota Jambi ini adalah metode kinesiotapping hold relax streatching, modalitas us phonoporesis selama 6 kali terapi dalam 3 minggu dapat menurunkan nyeri, meningkatkan kekuatan otot dan lingkup gerak sendi (LGS) pasien osteoarhtritis. Kesimpulan penelitian ini adalah us phonoporesis dapat menurunkan nyeri, kinesiotapping belum dapat meningkatkan kekuatan otot dan hold relax streatching dapat meningkatkan LGS pasien osteoarhtritis karena intervensi yang telah dilakukan dapat meningkatan kekuatan otot dan ketahanan otot intrinsik pada kaki, ketika otot intrinsik sudah kuat plantar fascia tidak bekerja dengan berat sehingga terjadi penurunan peradangan pada plantar fascia sehingga dapat meningkatkan aktifitas fungsional.
Seasonal gut contents of introduced Allegheny Crayfish (Faxonius obscurus) in an eastern Pennsylvania stream
Authors: Hartzell Sean M. , Wadena Lakota 
Published: November 2022

Abstract
Crayfish are important components of many freshwater ecosystems and play key roles as detritivores and/or carnivores. However, dietary studies are lacking for many species. Few data are available on the diet of Allegheny Crayfish (Faxonius obscurus), a common species native to western Pennsylvania and historically introduced into the central and eastern portions of the commonwealth. We collected Allegheny Crayfish from a site in eastern Pennsylvania from April to October and dissected specimens to evaluate the seasonal diet of this species. We found that gut contents in all months sampled primarily consisted of organic detritus (e.g., dead leaves and woody debris) and inorganic detritus (e.g., sand and silt), with small quantities of macroinvertebrate material and negligible vegetal material (macrophytes or algae). Generally, the diet of this species is similar those of other crayfish in the genus Faxonius.
A survey of soil bacterial diversity across a northeast Louisiana federal wildlife refuge
Authors: Minton Russell , Creech Clinton C. , Graham Daniel L. , Meyer Ashley D. 
Published: November 2022

Abstract
Soil microbial communities represent complex biological systems. Differences in these systems are attributable to a variety of factors, including soil series, plant communities, and anthropogenic land use. We assessed the microbial diversity of two ecoregions, three land usages, and seven soil series at Black Bayou Lake National Wildlife Refuge in Monroe, Louisiana. We found significant differences in beta diversity between ecoregions and the sites and soil series located within them. Bacteria associated with agricultural practices were significantly more abundant at Ouachita River Backswamp sites, reflecting the historical land use of these areas. We found no significant differences between a managed prairie fragment and the Backswamp sites, suggesting that the microbial communities have not changed over 20 years post restoration. Our data provide meaningful baseline measures of bacterial community diversity and abundance for the refuge and highlight the necessity of managing these valuable soil resources in conjunction with plant and animal communities.
The Effect of Different Extraction Temperatures of SARS-COV2 RT-PCR Examination Process On CT Value In Patient Specimens In Labkesda Kabupaten Sukabumi, Indonesia
Authors: Fadhilah Fitri Rahmi , Wahid Aziz Ansori , Rachman Mochamad Irwan Fitriana 
Published: November 2022

The Severe Acute Respiratory Syndrome Coronavirus-2, or COVID, was announced by WHO on February 11, 2020. Examination of SARS-CoV2 by RTq-PCR method in Labkesda Kab. Sukabumi is one of the health service support units in the Sukabumi area. The number of PCR examination requests is increasing every day, whereas, at this stage, the temperature increase process should reach the recommended temperature of 90°C, which can take 20-25 minutes. Sometimes ATLM has processed specimens at 60°C - 90°C. Given the required temperature at the time of extraction, which is at a temperature of 90 degrees, here the researchers wanted to prove whether below 90 degrees had an effect on the virus extraction process. This study aims to determine the effect of differences in extraction temperature on the SARS-CoV2 RTq-PCR examination process on CT VALUE on patient specimens. The variable in this study was the difference in temperature consisting of 60°C, 80°C, and 90°C. This research used quantitative research methods with case studies. This study is an experimental study to determine the effect of temperature differences on the CT value of the RTq - PCR examination. The population of this study were 30 patients at LABKESDA Kabupaten Sukabumi. This analysis used a one-way ANOVA test analysis with software. IBM SPSS 23.0. It may be concluded that there is no significant difference in the CT Value findings on the SARS-CoV2 RTq-PCR Examination since the study's p-value was 0.758, which is more than 0.05.
POLITICAL SCIENCE RESEARCH METHODOLOGY
Authors: Riak PhD Gabriel Alier , Bill Dut Bol Ayuel 
Published: November 2022

This is an area where there is considerable disagreement on the definition of concepts, and what is right and wrong. Accordingly you should read widely and critically; never assume that you need to accept every concept and every assertion. You will probably be able to find an exception to every rule (see Feyer bend, 1975, for an extreme version of this principle).
These notes are intended as a brief overview of the main issues. It is important that you read in more depth on the specific issues of particular concern to you. For example, if you intend to conduct some interviews or a questionnaire survey, it is important that you consult a suitable source of guidance on surveys, interviews and questionnaires – eg Saunders et al (2003), Robson (2002), Easterby-Smith et al (2002).
GOOD GOVERNANCE INITIATIVE IN THE LESS DEVELOPMENT COUNTRIES
Authors: Riak PhD Gabriel Alier , Bill Dut Bol Ayuel 
Published: November 2022

For the European Union and UNDP (2006), the quality of governance is ultimately attributed to its democratic content. Thereby the promotion of ‘democratic governance’ is a core element in their development assistance strategy. UNDP argues that human development and governance are inseparable. From the human development perspective UNDP has stated that ‘good governance’ is ‘democratic governance. According to Brandi (2008), Democratic Governance is the glue that holds all the other development priorities set out across the MDG’s together. In post-conflict societies it is much advocated by the international community that democratic systems provides the best mechanisms for reconciliation and are the best guarantors of lasting peace (Brandi &Clara, 2008).
According to Boex, Kimble and Pigey (2010), a government is essential to providing security, justice, economic, and social functions and to channeling the will, energies, and resources of both the indigenous population and the international community. According to Shah (2006), governments support peace building through encouraging institutional participation in peace building and democratic process of their countries.
CREDIT CONTROL ON DEVELOPMENT
Authors: Riak PhD Gabriel Alier , Bill Dut Bol Ayuel 
Published: November 2022

Credit risk management is defined as identification, measurement, monitoring and control of risk arising from the possibility of default in loan repayments (Abdifatah& Ogle, 2010). Also Ogilo, (2012) defines Credit Risk Management to involve the process of making decisions relating to the investment of funds. Such decisions should be carefully analyzed as they are characterized by an element of uncertainty (Wanjira, 2010).
Credit extended to borrowers may be at the risk of default such that whereas banks extend credit on the understanding that borrowers will repay their loans, some borrowers usually defaults and as a result, banks income decrease due to the need to provision for the loans (Gaitho, Wangui, 2010). Where the commercial banks do not have an indication of what proportion of their borrowers will default, earnings will vary thus exposing the banks to an additional risk ofvariability of their profits (Boateng, 2012). Every financial institution bears a degree of risk when the institution lends to business and consumers and hence experiences some loan losses when certain borrowers fail to repay their loans as agreed (Kairu, 2009).
GOVERNMENT POLICY
Authors: Riak PhD Gabriel Alier , Bill Dut Bol Ayuel 
Published: November 2022

Government policy define as an argues that the role of institutions needs to be recognized in resilience building because, while the technical aspects of mitigation measures are important, their acceptance by the institutions should not be underestimated. In Uganda for example operating outside the disaster management policy and established institutions during disaster relief may be disastrous to a particular organization or individual Ekotu, (2012). Fatemeh, (2011) argues for a synergy whereby civic engagement should serve to strengthen state institutions and where effective state institutions create an environment in which civic engagement is more likely to thrive. Government policy has the following attributes, Efficiency, Impact, Effectiveness and Relevance (Brooks, 2011).
The Olympic Movement and Cultural Policy: Historical Challenges and Ways Forward
Authors: Garcia Beatriz 
Published: November 2022

Abstract
Since its inception, the Olympic Movement has had a strong culture mandate, with “sport, culture and education” being presented as the essential pillars of Olympism in the Olympic Charter. Dedicated cultural programs—now called the Cultural Olympiad—have been a compulsory requirement at the Olympic Games since 1912; artists have always been welcome contributors to the Olympic narrative, and cultural values have informed the development of Olympic rituals from the outset. Despite this, John J. MacAloon and others have noted the lack of a coherent cultural policy framework within the movement and have debated the diversity and local sensitivity of the International Olympic Committee's cultural mandate and portfolio. This article reviews the significance of MacAloon's reflections on this subject since 2000 and interrogates the value of recent developments such as the role of culture within Agenda 2020, changes in the composition of the IOC Cultural and Olympic Heritage Commission, and the evolving positioning of the Cultural Olympiad as the leading contribution of Olympic host cities into the movement's cultural offer. The article concludes with reflections on the potential and challenges for fully inclusive, timely and representative Olympic cultural policies going forward.
Degree of Internationalization, Financial Structure and Cost of Capital: Evidence from Emerging Taiwan
Authors: Chang Ta-Cheng , Darcy John , Hou Yu-Ting , Yan Yun-Chia 
Published: November 2022

The debt structure of companies in Developing and Emerging Economies (DEEs) is significantly different from that of companies in the developed countries. This study examines the effect of degree of internationalization (DOI) on leverage ratio (LEV) and cost of capital (COC) in DEE setting by using a sample of Taiwan listed companies. Our results show that DOI has a significant positive impact on short-term debt as well as a significant negative impact on long-term debt. Therefore, it appears that DOI has a substitution effect in DEE companies. In summary, our results indicate that DEE firms do not have the advantage of participating in the international financial market.