bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital nursing factors associated with decreased odds of mortality in older adult Medicare surgical patients with depression
Authors: KUMAR APARNA , Sloane Douglas , Aiken Linda , McHugh Matthew 
Published: April 2022

Abstract
Background: Depression is common, costly, and has deleterious effects in older adult surgical patients. Little research exists examining older adult surgical patient outcomes and depression and the potential for nursing factors to affect these outcomes. The purpose of this study was to determine the relationship between hospital nursing resources, 30-day mortality; and the impact of depression on this relationship. Results: Every added patient per nurse was associated with a 4% increase in the risk-adjusted odds of mortality in patients with depression (p<0.05). Among all patients, every 10% increase in the proportion of bachelor’s prepared nurses was associated with a 4% decrease in the odds of mortality (p<0.001) and a one standard deviation increase in the work environment was associated with a 5% decrease in the odds of mortality (p<0.05). Conclusions: For older adult patients hospitalized for surgery, the risk of mortality is associated with higher patient to nurse ratio, lower proportion of BSN prepared nurses in the hospital, and worse hospital work environment. Addressing the mental health care needs of older adults in the general care hospital setting is critical to ensuring positive outcomes after surgery. Hospital protocols to lower the risk of surgical mortality in older adults with and without depression could include improving nurse resources.
Effects of field-grown transgenic Cry1Ah1 poplar on the rhizosphere microbiome
Authors: Wei Hui Wei , Movahedi Ali , Liu Guoyuan , Kiani-Pouya Ali , Rasouli Fatemeh , Yu Chunmei , Chen Yanhong , Zhong Fei , Zhang Jian 
Published: April 2022

Abstract
Populus is a genus of globally significant plantation trees used widely in industrial and agricultural production. Poplars are easily damaged by Micromelalopha troglodyta and Hyphantria cunea , resulting in decreasing quality. Because of their strong insect resistance, Bt toxin-encoded Cry genes have been widely adopted in poplar breeding. Therefore, the potential adverse effects of Cry1Ah1- modified (CM) poplars on the ecological environment have been concerned. The Illumina novaseq platform was used to perform high-throughput sequencing . Alpha diversity analyses were performed using the Chao1 index to determine community richness, and the Shannon index analyses were used to determine community richness and evenness. Our analysis of rhizosphere soil chemistry patterns revealed that rhizosphere soil available phosphorus, rhizosphere microbial biomass nitrogen, and rhizosphere phosphorus levels were declined. In contrast, rhizosphere microbial biomass carbon level increased in CM poplar rhizosphere samples. We applied metagenomic sequencing of non-transgenic (NT) and CM poplar rhizosphere samples collected from a natural field; the predominant taxa included Proteobacteria, Acidobacteria, and Actinobacteria. Together, these results showed that the Cry1Ah1 expression has no significant influences on the community composition of rhizosphere microbiomes . Also, the Cry1Ah1 expression in poplars has no notable effects on the relative abundances of most rhizosphere bacteria . In addition, there are no significant adverse effects of CM varieties on most rhizosphere fungal abundances. However, only a few rhizosphere fungal abundances differ in NT and CM varieties.
Weight Loss Severity and Functional Decline Among The Oldest Old in a Middle-Income Country: The Fibra Study Longitudinal Findings
Authors: Corona Ligiana Pires , Andrade Flavia C. D. , Borim Flavia S. A. , Aprahamian Ivan , Fattori André , Cesari Matteo , Neri Anita L. , Yassuda Mônica Sanches 
Published: April 2022

Abstract

Background and objective: Nutritional status is a key modifiable risk factor associated with disability, and further evidence suggests that weight change is also linked to this adverse outcome. Thus, the aim of this study is to evaluate weight loss severity and functional decline in instrumental activities of daily living (IADL) in a seven-year period among a sample of Brazilian oldest old adults. Methods: This is a longitudinal prospective study using data from FIBRA study (Frailty in Older Brazilians), a population-based investigation carried out in 2008/2009, with follow up data collected in 2016/2017 from participants who were 80 years and older in the follow-up in Campinas, Brazil. Of the 167 participants who were interviewed with complete data in 2016-2017, 16 had improved their functional status and were excluded, so the final sample was restricted to 151 participants who maintained or declined functional status. We considered functional decline when a subject had a greater number of IADL dependencies at follow‐up than at baseline. Logistic regression was performed to assess the effect of weight loss, according to severity (moderate weight loss: 5-10% of body weight; severe weight loss >10%) in increasing the number of disabilities, in relation to the group with stable weight, controlling for covariates (gender, age, education and morbidity). An alpha level <5% was adopted. Results: During the follow-up period, 60.3% of the participants kept stable weight, 21.8% had moderate weight loss and 17.9% had severe weight loss. During the follow-up, only severe weight loss was associated to higher risk of functional decline (OR=2.74;p=0.032). Conclusions: weight loss consisted in a risk factor to functional decline in this sample of oldest old, but severity of the loss must be considered as only severe loss was significant. Given that weight loss is expected for the oldest old, it is important to quantify this loss and measure its severity, and also to identify the magnitude of the loss that is associated with functional decline.
A Tailored Web-Based Video Intervention (ParentCoach) to Support Parents With Children With Sleeping Problems: User-Centered Design Approach
Authors: Preuhs Katharina , van Keulen Hilde , Andree Rosa , Wins Sophie , van Empelen Pepijn 
Published: April 2022

Background
Many parents frequently struggle with undesirable or problematic behavior (ie, temper tantrums and whining) displayed by their child. To support parents in promoting positive parenting skills (ie, recognizing challenging situations and reacting appropriately), the interactive video e-learning tool ParentCoach was developed. The tool aims to teach parents generic behavioral responses by means of situational learning, tailoring, and problem solving. The first demonstration focused on sleeping problems.

Objective
The aim of this paper is to illustrate the user-centered development of ParentCoach.

Methods
We conducted usability, understandability, and acceptance tests among the target group (29 parents, 7 youth health care professionals, and 4 individuals with former lower health literacy) in different phases of the development process via focus groups, interviews, and surveys. This allowed for relevant insights on specifications and user requirements to guide the development and revision of the tool in each iteration.

Results
Iterative testing and development allowed for the final demonstration of ParentCoach to be experienced as a relevant and accessible parenting intervention that can be used as a stand-alone program or in combination with another program.

Conclusions
This paper elaborates on the iterative development process and its benefits for the final demonstration of ParentCoach.
Barriers to Telemedicine Video Visits for Older Adults in Independent Living Facilities: Mixed Methods Cross-sectional Needs Assessment
Authors: Mao Alice , Tam Lydia , Xu Audrey , Osborn Kim , Sheffrin Meera , Gould Christine , Schillinger Erika , Martin Marina , Mesias Matthew 
Published: April 2022

Background
Despite the increasing availability of telemedicine video visits during the COVID-19 pandemic, older adults have greater challenges in getting care through telemedicine.

Objective
We aim to better understand the barriers to telemedicine in community-dwelling older adults to improve the access to and experience of virtual visits.

Methods
We conducted a mixed methods needs assessment of older adults at two independent living facilities (sites A and B) in Northern California between September 2020 and March 2021. Voluntary surveys were distributed. Semistructured interviews were then conducted with participants who provided contact information. Surveys ascertained participants’ preferred devices as well as comfort level, support, and top barriers regarding telephonic and video visits. Qualitative analysis of transcribed interviews identified key themes.

Results
Survey respondents’ (N=249) average age was 84.6 (SD 6.6) years, and 76.7% (n=191) of the participants were female. At site A, 88.9% (111/125) had a bachelor’s degree or beyond, and 99.2% (124/125) listed English as their preferred language. At site B, 42.9% (51/119) had a bachelor’s degree or beyond, and 13.4% (16/119) preferred English, while 73.1% (87/119) preferred Mandarin. Regarding video visits, 36.5% (91/249) of all participants felt comfortable connecting with their health care team through video visits. Regarding top barriers, participants at site A reported not knowing how to connect to the platform (30/125, 24%), not being familiar with the technology (28/125, 22.4%), and having difficulty hearing (19/125, 15.2%), whereas for site B, the top barriers were not being able to speak English well (65/119, 54.6%), lack of familiarity with technology and the internet (44/119, 36.9%), and lack of interest in seeing providers outside of the clinic (42/119, 35.3%). Three key themes emerged from the follow-up interviews (n=15): (1) the perceived limitations of video visits, (2) the overwhelming process of learning the technology for telemedicine, and (3) the desire for in-person or on-demand help with telemedicine.

Conclusions
Substantial barriers exist for older adults in connecting with their health care team through telemedicine, particularly through video visits. The largest barriers include difficulty with technology or using the video visit platform, hearing difficulty, language barriers, and lack of desire to see providers virtually. Efforts to improve telemedicine access for older adults should take into account patient perspectives.
Automated Decision Support For Community Mental Health Services Using National Electronic Health Records: Qualitative Implementation Case Study
Authors: van Kasteren Yasmin , Strobel Jörg , Bastiampillai Tarun , Linedale Ecushla , Bidargaddi Niranjan 
Published: April 2022

Background
A high proportion of patients with severe mental illness relapse due to nonadherence to psychotropic medication. In this paper, we use the normalization process theory (NPT) to describe the implementation of a web-based clinical decision support system (CDSS) for Community Mental Health Services (CMHS) called Actionable Intime Insights or AI2. AI2 has two distinct functions: (1) it provides an overview of medication and treatment history to assist in reviewing patient adherence and (2) gives alerts indicating nonadherence to support early intervention.

Objective
Our objective is to evaluate the pilot implementation of the AI2 application to better understand the challenges of implementing a web-based CDSS to support medication adherence and early intervention in CMHS.

Methods
The NPT and participatory action framework were used to both explore and support implementation. Qualitative data were collected over the course of the 14-month implementation, in which researchers were active participants. Data were analyzed and coded using the NPT framework. Qualitative data included discussions, meetings, and work products, including emails and documents.

Results
This study explores the barriers and enablers of implementing a CDSS to support early intervention within CMHS using Medicare data from Australia’s national electronic record system, My Health Record (MyHR). The implementation was a series of ongoing negotiations, which resulted in a staged implementation with compromises on both sides. Clinicians were initially hesitant about using a CDSS based on MyHR data and expressed concerns about the changes to their work practice required to support early intervention. Substantial workarounds were required to move the implementation forward. This pilot implementation allowed us to better understand the challenges of implementation and the resources and support required to implement and sustain a model of care based on automated alerts to support early intervention.

Conclusions
The use of decision support based on electronic health records is growing, and while implementation is challenging, the potential benefits of early intervention to prevent relapse and hospitalization and ensure increased efficiency of the health care system are worth pursuing.
Dampak Pembangunan Infrastruktur Terhadap Kondisi Ketahanan Pangan Di Indonesia (Studi Kasus Provinsi Bali)
Authors: Mulyani Sri , Putri Firda Mardhatillah , Andoko Bhimo Widyo , Akbar Paisal , Novalia Savira 
Published: April 2022

ABSTRACT This study had an aim to saw how the impact of infrastructure development on food resilience conditions in Indonesia, focusing on Bali Province. The result of infrastructure development was one of the main factors in realizing the presence of Food Resilience in Indonesia, so the government needed to built supporting infrastructure intended for people who had conditions far from food resilience and good infrastructure. This research used a descriptive method, with taking data from literatur, document, journal, and internet. This study found that the impact of infrastructure development was closely related to the condition of a region's resilience; Bali Province was one of the provinces that had a high food resilence index score, even in the national food resilience index ranking, Bali Province had an index score of 85.15 making Bali Province as the first place in food resilience when compared to other provinces. The food resilience conditions of regencies/cities in Bali Province also showed high index scores; this could be seen in the last two years the position of Denpasar City, Tabanan Regency, Gianyar Regency, and Badung Regency to became cities and regencies that occupied the highest place in the national food resilience index score. Penelitian ini bertujuan untuk melihat bagaimana dampak pembangunan infrastruktur terhadap kondisi ketahanan pangan di Indonesia yang berfokus di Provinsi Bali. Perkembangan pembangunan infrastruktur menjadi salah satu faktor utama untuk mewujudkan hadirnya Ketahanan Pangan di Indonesia, sehingga pemerintah perlu membangun infrastruktur penunjang yang diperuntukkan bagi masyarakat yang memiliki kondisi jauh dari angka ketahanan pangan dan infrastruktur yang baik.Penelitian ini menggunakan metode deskriptif, dengan mengambil data dari kepustakaan, dokumen, jurnal, dan internetPenelitian ini menemukan bahwa dampak pembangunan infrastruktur menjadi sangat berkaitan dengan kondisi ketahanan suatu wilayah, Provinsi Bali menjadi salah satu provinsi yang memiliki skor indeks ketahanan pangan yang tinggi, bahkan dalam ranking indeks ketahanan pangan nasional Provinsi Bali memiliki skor indeks 85,15 menjadikan Provinsi Bali sebagai urutan pertama dalam ketahanan pangan jika dibandingkan dengan provinsi-provinsi lainnya. Kondisi ketahanan pangan kabupaten/kota di Provinsi Bali juga menunjukkan skor indeks yang tinggi, hal ini dapat dilihat dalam 2 tahun terakhir posisi Kota Denpasar, Kabupaten Tabanan, Kabupaten Gianyar dan Kabupaten Badung menjadi kota dan kabupaten yang menduduki posisi teratas dalam skor indeks ketahanan pangan nasional.
Penguatan Nilai-Nilai Ketahanan Nasional Di Sekolah Melalui Pendidikan Kewarganegaraan (Studi Di SMK Pusdikhubad Kota Cimahi, Jawa Barat)
Authors: Halimah Lili , Suryaningsih Anis Suryaningsih , Hidayah Yayuk , Ulfah Risti Aulia 
Published: April 2022

ABSTRACT The idea of the strengthening of citizenship values came with implications on the perspective of realizing national resilience in the school. The purpose of this study was to analyzed the strengthening of citizenship values to realized national resilience in the School environment. This research used a qualitative approach with a case study design. Data collection used interview, observation and documentation techniques. Data analysis used interactive analysis consisting of data reduction, data presentation and data verification. The results showed that strengthening the values of citizenship to realized national resilience in the school environment was through three ways, namely: 1) learning innovative citizenship education, 2) internationalizing the values of national resilience in the school environment by habituation and 3) the existence of extracurricular activities which was a discussion forum for students to deepened the values of national resilience in the school environment. Citizenship values were important for students because they would form a person who had a national spirit, loves the motherland and had an identity as an Indonesian nation. ABSTRAK Gagasan penguatan nilai-nilai kewarganegaraan hadir dengan implikasi pada perspektif mewujudkan ketahanan nasional pada lingkungan sekolah. Tujuan penelitian ini menganalisis penguatan nilai-nilai kewarganegaraan dalam mewujudkan ketahanan nasional pada lingkungan sekolah.Penelitian ini menggunakan pendekatan kualitatif dengan disain studi kasus. Pengumpulan data menggunakan teknik wawancara, observasi dan dokumentasi. Analsisi data menggunakan analisis interaktif yang terdiri dari reduksi data, penyajian data dan verifikasi data.Hasil penelitian menunjukkan bahwa penguatan nilai-nilai kewarganegaraan untuk mewujudkan ketahanan nasional pada lingkungan sekolah dilakukan melalui tiga cara, yaitu: 1) pembelajaran pendidikan kewarganegaraan yang inovatif, 2) internasliasi nilai-nilai ketahanan nasional pada lingkungan sekolah dengan pembiasaan dan 3) adanya aktivitas ekstra kurikuler yang menjadi forum diskusi bagi siswa dalam memperdalam nilai-nilai ketahanan nasional pada lingkungan sekolah. Nilai-nilai kewarganegaraan penting bagi siswa karena akan membentuk pribadi yang memiliki jiwa nasioalisme, cinta tanah air dan memiliki identitas sebagai bangsa Indonesia.
Ketahanan Ideologi Pancasila Dalam Menghadapi Distrupsi Revolusi Industri 4.0
Authors: Karsayuda H.M Rifqinizamy , Tektona Rahmadi Indra 
Published: April 2022

ABSTRACTThe era of disruption that occurred globally had affected all human life in various fields, both in the economic, social, cultural, political, educational and other fields. Disruption had a positive impact, but it would also have a negative impact if it was not treated wisely. Geostrategy could be used as an effort to maintained ideological resilience, which was one of the basic things needed in realizing national resilience.The research method used in this article was normative research; the research stage, literature study; and deductive analysis, the type of research approach used was the conceptual approach and the statutory approach. This study discussed Pancasila as the source of all sources of law as well as the ideology of Indonesia's geostrategic resilience in the face of an era of global disruption. The author also used the literature methodIn this era of global disruption, Pancasila as the basis of the state and the nation's outlook on life played an important role in being able to filtered new values, by applying Pancasila values in all aspects of national life so as to maintained national resilience while still paying attention to the existence of Indonesian geostrategy which had Pancasila as an ideology of geostrategic resilience which was a reflection of the existing values and lives of the precepts contained in it.ABSTRAKDistrupsi industri 4.0 telah mempengaruhi seluruh kehidupan manusia di berbagai bidang, baik di bidang ekonomi, sosial, budaya, politik, pendidikan, dan bidang lainnya. Memberikan dampak positif dan negatif jika tidak disikapi dengan bijak. Geostrategi dapat dimanfaatkan sebagai upaya menjaga ketahanan ideologi yang merupakan salah satu hal dasar yang diperlukan dalam mewujudkan ketahanan nasional.Metode penelitian yang digunakan dalam artikel ini adalah penelitian normatif; tahap penelitian, studi kepustakaan; dan analisis deduktif, jenis pendekatan penelitian yang digunakan adalah pendekatan konseptual dan pendekatan perundang-undangan. Penelitian ini membahas mengenai Pancasila sebagai sumber segala sumber hukum yang juga sebagai ideologi ketahanan geostrategi Indonesia dalam menghadapi era global. Peneliti juga menggunakan metode kepustakaan (library research).Dalam distrupsi industri 4.0, Pancasila sebagai dasar negara dan pandangan hidup bangsa memegang peranan penting untuk dapat menjadi filter nilai-nilai baru, dengan menerapkan nilai-nilai Pancasila dalam segala aspek kehidupan nasionalnya diharapkan mampu mempertahankan ketahanan nasional dengan tetap memperhatikan eksistensi geostrategi Indonesia.
Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy
Authors: Goni Mallikarjun , Javaregowda Palaksha Kanive , Chachadi Vishwanath , Virupakshaiah DBM 
Published: April 2022

Abstract

Background
Sialic acids are alpha-keto acids with nine carbons that are commonly present in the terminal sugars of glycans on glycoproteins and glycolipids on the cell surface. Sialic acids have a role in a variety of physiological and pathological processes by interacting with carbohydrates and proteins, communicating between cells, and acting as cell surface receptors for viruses and bacteria. Several studies have shown the aberrant pattern of sialic acids on cancer cells due to change in their glycosylation status. This pattern may be attributed to various physiological and pathological changes occurring in tumour cells. Hypersialylation in tumours, its involvement in tumour growth, immune evasion and escape from the apoptotic pathway, metastasis formation, and therapeutic resistance have all been fairly well investigated.

Methods
A PubMed search was conducted and published articles in different studies from 2000 to 2020 were included and reviewed. Here, we discuss current outcomes that emphasize the unfavourable effects of hypersialylation on multiple aspects of tumour genesis, immune evasion, metastasis and resistance to therapy.

Conclusion
These recent investigations have found that aberrant sialylation is an essential process for tumour cells to evade immune surveillance and maintain their malignancy. Together, these noteworthy views provide a solid platform for designing and developing therapeutic approaches that target hypersialylation of cancer cells.
Myositis-specific antibodies: Overview and clinical utilization
Authors: Halilu Fatima , Christopher-Stine Lisa 
Published: April 2022

Abstract
Purpose of review—To review autoantibodies associated with different subtypes of idiopathic inflammatory myopathy (IIM) and their clinical applications. IIM are a heterogenous group of autoimmune disorders characterized by muscle weakness, cutaneous features, and internal organ involvement. The diagnosis and classification, which is often challenging, is made using a combination of clinical features, muscle enzyme levels, imaging, and biopsy. The landmark discoveries of novel autoantibodies specific to IIM subtypes have been one of the greatest advancements in the field of myositis. The specificity of these autoantibodies has simplified the diagnostic algorithm of IIM with their heterogenous presentation and outdated the earlier diagnostic criteria. Myositis-specific antibodies (MSAs) have improved diagnostics, clinical phenotyping, and prognostic stratification of the subtypes of IIMs. Furthermore, the levels of certain MSAs correlate with disease activity and muscle enzyme levels such that titers may be able to be used to predict disease course and treatment response.