bluuebunny/crossref_metadata_2025_split huggingface dataset:
TLR4 promoted endoplasmic reticulum stress induced inflammatory bowel disease via the activation of p38 MAPK pathway
Authors: Hu Tian , Zhao Yan , Long Yan , Ma Xiaoqing , Zeng Ya , Wu Weijie , Deng Chongtian , Li Mengling , Peng Siyuan , Yang Hanzhi , Zhou Mi , Hu Jinyue , Shen Yueming 
Published: March 2022

Abstract
Endoplasmic reticulum (ER) stress contribute to inflammatory bowel disease (IBD). However, the mechanistic link between toll-like receptor 4 (TLR4) and ER stress in IBD remains elusive. This study aimed to investigate the mechanism by which ER stress and TLR4 promote inflammation in IBD.
IBD mouse model was established by the induction of TNBS, and Grp78 and TLR4 in intestine tissues were detected by immunohistochemistry. THP-1 cells were treated with lipopolysaccharides (LPS), ER stress inducer or inhibitor tauroursodeoxycholic acid (TUDCA), or p38 MAPK inhibitor. The activation of MAPK signaling was detected by Western blot, and the production and secretion of inflammatory factors were detected by PCR and ELISA. We found that the expression levels of TLR4 and GRP78 were significantly higher in the intestine of IBD model mice compared with control mice but were significantly lower in the intestine of IBD model mice treated with ER stress inhibitor TUDCA. ER stress inducer significantly increased while ER stress inhibitor TUDCA significantly decreased the expression and secretion of TNF-α, IL-1β and IL-8 in THP-1 cells treated by LPS. Only p38 MAPK signaling was activated in THP-1 cells treated by ER stress inducer. Furthermore, p38 inhibitor SB203580 inhibited the production and secretion of TNF-α, IL-1β and IL-8 in THP-1 cells treated with LPS. In conclusion, TLR4 promotes ER stress induced inflammation in IBD, and the effects may be mediated by p38 MAPK signaling. TLR4 and p38 MAPK signaling are novel therapeutic targets for IBD.
Structural Validity, Internal Consistency, and Rater Reliability of the Modified Barium Swallow Impairment Profile: Breaking Ground on a 52,726-Patient, Clinical Data Set
Authors: Clain Alex E. , Alkhuwaiter Munirah , Davidson Kate , Martin-Harris Bonnie 
Published: March 2022

Purpose:
The purpose of this study was to extend the assessment of the psychometric properties of the Modified Barium Swallow Impairment Profile (MBSImP). Here, we re-examined structural validity and internal consistency using a large clinical-registry data set and formally examined rater reliability in a smaller data set.

Method:

This study consists of a retrospective structural validity and internal consistency analysis of MBSImP using a large data set (
N
= 52,726) drawn from the MBSImP Swallowing Data Registry and a prospective study of the interrater and intrarater reliability of a subset of studies (
N
= 50) rated by four MBSImP-trained speech-language pathologists. Structural validity was assessed via exploratory factor analysis. Internal consistency was measured using Cronbach's alpha for each of the multicomponent MBSImP domains, namely, the oral and pharyngeal domains. Interrater reliability and intrarater reliability were measured using the intraclass correlation coefficient (ICC).

Results:

The exploratory factor analysis showed a two-factor solution with factors precisely corresponding to the scale's oral and pharyngeal domains, consistent with findings from the initial study. Component 17, that is, the esophageal domain, did not load onto either factor. Internal consistency was good for both the oral and pharyngeal domains (α
oral
= .81, α
pharyngeal
= .87). Interrater reliability was found to be good with ICC
interrater
= .78 (95% confidence interval [CI; .76, .80]). Intrarater reliability was good for each rater, ICC
Rater-1
= .82 (95% CI [.77, .86]), ICC
Rater-2
= .83 (95% CI [.79, .87]), ICC
Rater-3
= .87 (95% CI [.83, .90]), and ICC
Rater-4
= .87 (95% CI [.83, .90]).

Conclusions:
This study leverages a large-scale, clinical data set to provide strong, generalizable evidence that the MBSImP assessment method has excellent structural validity and internal consistency. In addition, the results show that MBSImP-trained speech-language pathologists can demonstrate good interrater and intrarater reliability.
Sharing strategy development of a cloud energy storage system in energy management of a microgrid considering sustainable and telecommunication‐assisted architecture
Authors: Khoshniyyat Saeid , Majidzadeh Maryam 
Published: March 2022

AbstractThis paper explores residential microgrids (MG) which not only deploy smart algorithms and energy management strategies for appliances scheduling but also make benefit of insulated wall structures and modern windows ending to smart buildings with sustainable architecture. This amendment is shown to have a remarkable effect on avoiding thermal energy losses and hence lowering energy consumption of heat, ventilation, and air conditioning system (HVAC) in smart and sustainable homes. Moreover, frequency selective surfaces applied in modern windows are shown to greatly improve in‐service telecommunication signal transfer ratio, assuring a reliable communication for inhabitants. The proposed model adopts the most recent concept of cloud energy storage system (CESS) unit to provide a public access to charge/discharge capacity for smart home owners. Accordingly, a simple but applicable capacity sharing strategy of CESS is developed for the energy exchanges of smart homes in the MG. By establishing such an access to CESS, the proposed model allocates optimal shares of charge/discharge capacities for home owners, minimizes the daily operation cost of each home and grants an optimal operation of household appliances. The proposed model is formulated as a mixed integer linear programming (MILP) problem and is assessed in several operating strategies.
Social exchanges and peer-to-peer accommodation: residents' perceptions in a neighbourhood context.
Authors: Stergiou Dimitrios , Farmaki Anna , Efthymiadou Fani 
Published: March 2022

Abstract

The rapid growth of peer-to-peer (P2P) accommodation has challenged the sustainability efforts of destinations, due to the numerous negative impacts accrued from the influx of tourists in residential areas. Even so, scant attention has been paid to the perceptions of local residents with regard to associated impacts. This chapter aims to examine the perceptions of the residents of Koukaki (Athens, Greece) regarding the impacts of Airbnb at the neighbourhood level, using social exchange theory. Findings reveal a dominance of negative perceptions of socio-economic and environmental impacts and identify attempts from residents to mitigate associated impacts. Drawing from the literature and empirical findings, the chapter offers a framework which acknowledges the mediating role of platforms and property owners in the social exchanges between residents and guests. The chapter concludes with a discussion of implications, contributing towards the adoption of an anthropocentric and inclusive approach on P2P accommodation.
Airbnb host responsibilities and community resilience: the case of Japan.
Authors: Kaniadakis Antonios , Hayakawa Chiga , Farmaki Anna 
Published: March 2022

Abstract

In Japan, the shortage of accommodation facilities has become a concern due to the increasing number of tourists. In light of the 2020 Olympic and Paralympic Games (moved to 2021 due to the coronavirus disease 2019 (COVID-19) pandemic), this problem is likely to escalate and raises the need for the authorities to deal with the temporary influx of tourists. Private lodging emerges as a possible solution to this problem and also as a way to revitalize regions and repopulate vacant houses. Considering the Private Lodging Business Act recently established in Japan, this chapter explores Airbnb hosts' perceptions of their responsibilities. This leads to an increase in our understanding of the associated implications of these hosts' practice on the resilience of the local community. Drawing from semi-structured interviews with 16 Japanese hosts, we reveal insights on hosts' perceived responsibilities in the peer-to-peer accommodation context and how hosts and platforms can contribute to community resilience.
Possible existence of chiral and multiple chiral nuclei in thallium isotopes *
Authors: Guo Rui-Ju , Lu Xiao , Qi Bin , Liu Chen , Wang Shou-Yu 
Published: March 2022

Abstract
The chirality in thallium isotopes is investigated using the adiabatic and configuration-fixed constrained triaxial relativistic mean field theory. Several minima with prominent triaxial deformation and proper configuration, where the chiral doublet bands may appear, are obtained in odd-odd nuclei

Tl and odd-mass nuclei

Tl. Furthermore, the possible existence of multiple chiral doublet bands (MχD) is demonstrated in

Tl. As the chiral doublet bands in

Tl and MχD in 195Tl have been observed experimentally, further experimental exploration for the chirality in

Tl and MχD in thallium isotopes is expected to verify the predictions.
Target dependence of isotopic cross sections in the spallation reactions 238U + p, d and 9Be at 1 AGeV *
Authors: Song Qu-Fei , Zhu Long , Su Jun 
Published: March 2022

Abstract
The spallation of 238U is an important way to produce rare isotopes. This work aims at studying the cross sections of isotopes produced in 238U + p, d and 9Be reactions at 1 A GeV and their target dependence. (1) A physical model dependent (Bayesian neural network) BNN, which includes the details of IQMD-GEMINI++ model and BNN, was developed for a more accurate evaluation of production cross sections. The isospin-dependent quantum molecular dynamics (IQMD) model is used to study the non-equilibrium thermalization of the 238U nuclei and fragmentation of the hot system. The subsequent decay of the pre-fragments is simulated by the GEMINI++ model. The BNN algorithm is used to improve the prediction accuracy after learning the residual error between experimental data and calculations by the IQMD-GEMINI++ model. It is shown that the IQMD-GEMINI++ model can reproduce the available experimental data (3282 points) within 1.5 orders of magnitude. After being fine tuned by the BNN algorithm, the deviation between calculations and experimental data were reduced to within 0.4 order of magnitude. (2) Based on the predictions by the IQMD-GEMINI++-BNN framework, the target dependence of isotopic cross sections was studied. The cross sections to produce the rare isotopes by the 238U + p, d and 9Be reactions at 1 A GeV are compared. For the generation of neutron-rich fission products, the cross sections for the 238U + 9Be are the largest. For the generation of neutron-deficient nuclei in the region of A = 200–220, the cross sections for 238U + p reaction are the largest. Considering the largest cross sections and the atomic density, the beryllium target is recommended to produce the neutron-rich fission products by the 238U beam at 1 A GeV, while the liquid-hydrogen target is suggested to produce the neutron-deficient nuclei in the region of A
= 200–220.
Electrocorticographic effects of acute ketamine on non-human primate brains
Authors: Yan Tianfang , Suzuki Katsuyoshi , Kameda Seiji , Maeda Masashi , Mihara Takuma , Hirata Masayuki 
Published: March 2022

Abstract

Objective. Acute blockade of glutamate N-methyl-D-aspartate receptors by ketamine induces symptoms and electrophysiological changes similar to schizophrenia. Previous studies have shown that ketamine elicits aberrant gamma oscillations in several cortical areas and impairs coupling strength between the low-frequency phase and fast frequency amplitude, which plays an important role in integrating functional information. Approach. This study utilized a customized wireless electrocorticography (ECoG) recording device to collect subdural signals from the somatosensory and primary auditory cortices in two monkeys. Ketamine was administered at a dose of 3 mg kg−1 (intramuscular) or 0.56 mg kg−1 (intravenous) to elicit brain oscillation reactions. We analyzed the raw data using methods such as power spectral density, time-frequency spectra, and phase-amplitude coupling (PAC). Main results. Acute ketamine triggered broadband gamma and high gamma oscillation power and decreased lower frequencies. The effect was stronger in the primary auditory cortex than in the somatosensory area. The coupling strength between the low phase of theta and the faster amplitude of gamma/high gamma bands was increased by a lower dose (0.56 mg kg−1 iv) and decreased with a higher dose (3 mg kg−1 im) ketamine. Significance. Our results showed that lower and higher doses of ketamine elicited differential effects on theta-gamma PAC. These findings support the utility of ECoG models as a translational platform for pharmacodynamic research in future research.
Analysis of hydrology parameters in a tropical wetland as an early approach to identify a drought risk in a peatland area
Authors: Amal Nilna , Helda Noordiah , Rusdiansyah Achmad , Ramadhani Wijayanto M. , Muammar Fadhiil 
Published: March 2022

Abstract
The hydrological condition can be determined by investigating local data or analyzing historical climatological records. Several methods can approach the wetland condition, including peatland in general. The definition of physical properties to assess critical groundwater table depths is one of them. Another way is to define the requirements in the area that can be approached by determining the condition of the wetland area for general. Understanding and assessing the wetland state is necessary to measure and evaluate the wetland situation, and it can be done by analyzing wetland hydrology parameters. Due to the necessity to mitigate change conditions in a wetland, it is common to know that either flood or drought will derive a difficult situation both in a wetland and a peatland but especially for a peatland, drought condition is severe. This study aims to observe the wetland condition and identify whether the wetland area has drought risk potential, especially in the peatland site. The study was conducted by directly taking data from the study location and downloading satellite data from local and regional websites: the local climatology agency Badan Meteorologi, Klimatologi dan Geofisika (BMKG Indonesia), and the Jaxa website. The data from satellite needs to be used related to the limitation of ground data in the study location. The result showed that the satellite has an excellent relationship to the ground data with a pretty low root mean square error (RMSE) number. In addition, it showed the correlation between the amount of monthly rainfall and evapotranspiration with the water table elevation. It can be concluded at the initial conclusion that the decreased rainfall and the high evapotranspiration in a particular month can be expected the drought risk potentially will happen.
Identification of quality of irrigation water Danda Besar Swamp Irrigation Area in Barito Kuala District, South Kalimantan, Indonesia
Authors: Noorsaly S R , Yuichiro M , Achyadi M A 
Published: March 2022

Abstract
Danda Besar Swamp Irrigation Area (SIA) is located in Danda Jaya Village in Rantau Badauh District, Barito Kuala Regency, South Kalimantan Province, Indonesia. It is one of tidal swamp reclamation where tidal fluctuation of Barito River affects to the hydrological condition. Danda Besar SIA has potential agricultural land about 2, 200 ha, and the productivity of paddy field was only 2 ton/ha in average for each time planting year. Two ton/ha is too low productivity due to problem of water quality in irrigation canal. However, fundamental information for the management of water quality of irrigation, monitoring data of water quality, is not measured yet. This fundamental research was conducted to identify and analyze condition of irrigation water quality. The field survey was carried out in dry months, May and June 2021 at primary canal, secondary canal, tertiary canal and pond. The final result for 6 parameters of the 4 locations (primary canal, secondary canal, tertiary canal and pond) showed there were 3 parameters (TDS, DO, and Sulfate (SO4
2-)) fulfill the class II standard, meanwhile there were 3 parameters (pH, Iron (Fe) and BOD) not fulfill the class II standard according to Government Regulation No. 22 year 2021 regarding Implementation of Environmental Protection and Management. The high content of Iron (Fe) and low content of pH recorded in all water sources should be addressed with urgency since this phenomenon as a result of pyrite oxidation affect to pH condition and may cause the low productivity of paddy field.
Performance of Drip and Mist Irrigation to Supply Water for Vegetable
Authors: Murtiningrum Murtiningrum , Nawan Rasyid Ilham , Christyaningrum Lia , Fahrunisa Erlina , Ngadisih Ngadisih 
Published: March 2022

Abstract
Irrigation or water use for agriculture is the biggest water consumer. Reducing water use for irrigation means significantly to water saving. Drip and mist irrigations are methods of water application which consume water more efficiently and more agriculture products produce from same amount of water. This research aimed to assess performance off drip irrigation and mist irrigation to supply irrigation water for vegetables. The vegetables cultivated were spinach, mustard, and water spinach. The indicators employed were discharge, uniformity, dan water productivity. The research results showed that average discharges of drip and mist irrigations were 0.0056 litre/second and 0.0012 litre/second, respectively. The uniformity was measured using distribution uniformity (DU) and Christiansen uniformity index (CU). The DU of drip and mist irrigations were 0.84 and 0.76, respectively. The CU of drip and mist irrigations were 0.76 and 0.82, respectively. The biomass water productivities of spinach, mustard, and water spinach irrigated with drip irrigation were 2.23, 9.51, and 7.92, respectively. The biomass water productivities of spinach, mustard, and water spinach irrigated with mist irrigation were 0.98, 8.70, and 9.10, respectively.
Application of activated charcoal- sugarcane bagasse material for adsorption of COD (Chemical Oxygen Demand) on the sasirangan wastewater
Authors: Noor R , Annisa N , Paramitha D M , Prasetia H 
Published: March 2022

AbstractIn Indonesia, there is a significant amount of sugarcane bagasse waste that has not been utilized optimally. Around 50% of sugarcane bagasse waste is discarded as waste with little economic value. Sugarcane bagasse contains lignocellulose, composed of 20% hemicellulose, 52.75% cellulose, 20% pentosan, and 37.55% lignin and converted into activated charcoal. Sugarcane bagasse can be used as an alternative raw material for activated charcoal by carbonizing it in a batch process to remove organic compounds from the waste. On this basis, a study was conducted to determine the effectiveness of bagasse activated charcoal in reducing the COD content of sasirangan waste and the optimal dose of bagasse activated charcoal as an adsorbent in reducing the COD content of sasirangan wastewater.The steps to make activated carbon are by place small pieces of bagasse in the mortar and place in a 350°C furnace for 2 hours or until the sample turns black. Next, bagasse charcoal was sieved until smooth using a 100-mesh sieve. The following stage is chemical activation. Bagasse that has passed through the sieve is soaked in 0.1 N 20% HCl activator for the day—cleansing the activated charcoal with distilled water until the pH is neutral. The next step is physical activation, which involves heating the activated charcoal in an oven at 105°C for six hours to dehydrate it. The results indicated that bagasse activated charcoal with a pH of 5 and a contact time of 90 minutes could reduce the COD content of the Sasirangan wastewater by up to 95.37 % and that the dose of bagasse activated charcoal as an adsorbent had a significant effect on the COD content. The quantity of 5 g/L is the maximum number of COD that can be absorbed. Keyword: Activated Charcoal, COD, sasirangan wastewater
Edible Film Fabrication derived from Nagara Starch and Red Ginger Essential Oil as a Package of Instant Noodles Seasoning
Authors: Elma Muthia , Pradana Eggy A. , Sihombing Natalia , Noor Thala’ah Rizky , Rahma Aulia , Rampun Erdina L. A. 
Published: March 2022

Abstract
Instant noodles are very popular among Indonesian people. It is due to its cheap and easy to serve. Therefore, the consumption of instant noodles may increase every year based on the population. However, the increase in consumption of instant noodles has an impact on the plastic waste generated that will be caused pollution into the environment due to difficult to degrade. Edible film from Nagara starch with red ginger essential oil is potentially used as food packaging due to easily degraded and environmentally friendly. Nagara starch was synthesis from Nagara sweet potato which locally growth in South Kalimantan, Indonesia. Edible film was fabricated by mixing and heating nagara sweet potato starch with demineralized water until boiled, then followed by added glycerol, sorbitol and stirrer until homogeneous for 45 min. The obtain solution was heating down until 40 °C which afterward added the red ginger essential oil with varied concentration (0-1.5 % wt.) and mixed for 20 min. The film was casted and dried in oven for 24 h at 60 °C. All edible film with different red ginger essential oil concentration characterized by water resistant, water solubility, thickness, elongation, tensile strength and microbial test. The nagara starch edible film has successfully fabricated with addition red ginger essential oil and shows physical characteristics of white, slightly yellow, clear, transparent, thin and tends to be elastic. The result exhibits nagara edible film (1 % red ginger essential oil) has good characteristic according to water resistant (58.3 %), water solubility (33 %), tensile strength (1.84 N/mm2), elongation (17.9 %), and thickness analysis (260 mm). The obtained edible film was suitable for packaging instant noodles seasoning. In other hand, the presence of red ginger essential oil in edible film has critical role for maintaining the food from microbes due to it acts as antimicrobial agent.