bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain morphometric abnormalities and their associations with affective symptoms in males with methamphetamine use disorder during abstinence
Authors: Hu Xinyue , Jiang Ping , Gao Yingxue , Sun Jiayu , Zhou Xiaobo , Zhang Lianqing , Qiu Hui , Li Hailong , Cao Lingxiao , Liu Jing , Gong Qiyong , Huang Xiaoqi 
Published: October 2022

BackgroundMethamphetamine (METH) use induces neurotoxic effects in brain structures and affective symptoms that persist during abstinence. However, the brain morphometry of individuals with METH use disorder (MUD) remains unclear, as well as their associations with affective symptoms during abstinence.MethodsForty-eight abstinent males with MUD and 66 age-, sex-, and education-matched healthy controls (HCs) underwent high-resolution T1-weighted magnetic resonance imaging. Cortical thickness, surface area, volume, local gyrification index (LGI), and subcortical volume were obtained with FreeSurfer software. Brain morphometry differences between groups and their associations with affective symptoms and drug abuse history within the males with MUD were examined, with intracranial volume, age, and years of education as covariates.ResultsCompared with the HCs, the individuals with MUD showed a significantly higher LGI in the right cuneus gyrus, left lingual gyrus, bilateral supramarginal gyrus, right inferior parietal gyrus (IPG), and right dorsal anterior cingulate cortex (clusterwise p &lt; 0.05, Monte Carlo-corrected), as well as a smaller volume of the left nucleus accumbens (NAcc) (p &lt; 0.05, FDR-corrected). However, there were no significant group differences in cortical thickness, area or volume. In addition, the LGI in the right IPG was positively associatedwith the severity of depression and anxiety symptoms in MUDs (p &lt; 0.05, FDR-corrected).ConclusionBrain morphometric abnormalities in abstinent males with MUD were characterized by hypergyrification across multiple mid-posterior brain regions anda smaller volume of the left NAcc.Gyrification of the right IPG may be a potential neural substrate underlying the affective symptoms experienced by MUDs during abstinence.
The significant association between quick return and depressive symptoms and sleep disturbances in paid workers: A nationwide survey
Authors: Yun Byungyoon , Sim Juho , Oh Juyeon , Kim Yangwook , Yoon Jin-Ha 
Published: October 2022

ObjectivesAlthough many studies have examined the association between shift work and depression or insomnia, few studies have examined the relationship between quick return (QR) to work and depressive symptoms, regardless of shift work. Thus, in this study, we aimed to assess the association between depressive symptoms (DS)/sleep disturbances (SDs) and QR.MethodsData from the 6th Korean Working Conditions Survey (2020) were used for this study. Paid workers aged between 20 and 65 years were included. DS were defined using the World Health Organization Well-Being Index (WHO-5) with a cut-off 50, and SD was defined as the occurrence of the following symptoms several times per month: difficulty in falling asleep, waking up in the middle of the night, or feeling tired even after waking up. QR was defined as “at least one case where the working interval between leaving work and the next day's work was &lt; 11 h in the past month.” Multivariable logistic regression was performed to estimate the adjusted odd ratios (aORs) and 95% confidence intervals (CIs). Mediation analysis was conducted to examine whether SD was a significant mediator in the association between QR and DS.ResultsAmong the 27,554 participants, DS occurred in 8,277 patients, while SD occurred in 6,264 patients. The aORs (95% CIs) of DS and SD by QR were 2.01 (1.78–2.27) and 3.24 (2.87–3.66), respectively, after adjusting for age, gender, income, education, working hours, job status, working duration, region, shift work, and occupation. SD was a significant mediator in the association between QR and DS.ConclusionQR is significantly associated with DS or SD regardless of demographic factors and the working environment. The significant relationship between QR and DS may be mediated by SD.
Decision support by machine learning systems for acute management of severely injured patients: A systematic review
Authors: Baur David , Gehlen Tobias , Scherer Julian , Back David Alexander , Tsitsilonis Serafeim , Kabir Koroush , Osterhoff Georg 
Published: October 2022

IntroductionTreating severely injured patients requires numerous critical decisions within short intervals in a highly complex situation. The coordination of a trauma team in this setting has been shown to be associated with multiple procedural errors, even of experienced care teams. Machine learning (ML) is an approach that estimates outcomes based on past experiences and data patterns using a computer-generated algorithm. This systematic review aimed to summarize the existing literature on the value of ML for the initial management of severely injured patients.MethodsWe conducted a systematic review of the literature with the goal of finding all articles describing the use of ML systems in the context of acute management of severely injured patients. MESH search of Pubmed/Medline and Web of Science was conducted. Studies including fewer than 10 patients were excluded. Studies were divided into the following main prediction groups: (1) injury pattern, (2) hemorrhage/need for transfusion, (3) emergency intervention, (4) ICU/length of hospital stay, and (5) mortality.ResultsThirty-six articles met the inclusion criteria; among these were two prospective and thirty-four retrospective case series. Publication dates ranged from 2000 to 2020 and included 32 different first authors. A total of 18,586,929 patients were included in the prediction models. Mortality was the most represented main prediction group (n = 19). ML models used were artificial neural network ( n = 15), singular vector machine (n = 3), Bayesian network (n = 7), random forest (n = 6), natural language processing (n = 2), stacked ensemble classifier [SuperLearner (SL), n = 3], k-nearest neighbor (n = 1), belief system (n = 1), and sequential minimal optimization (n = 2) models. Thirty articles assessed results as positive, five showed moderate results, and one article described negative results to their implementation of the respective prediction model.ConclusionsWhile the majority of articles show a generally positive result with high accuracy and precision, there are several requirements that need to be met to make the implementation of such models in daily clinical work possible. Furthermore, experience in dealing with on-site implementation and more clinical trials are necessary before the implementation of ML techniques in clinical care can become a reality.
Eco-Friendly Synthesis of an Oxovanadium(IV)-bis(abietate) Complex with Antimicrobial Action
Authors: Schons Aline B. , Correa Jamille S. , Appelt Patricia , Meneguzzi Daiane , Cunha Mário A. A. , Bittencourt Carla , Toma Henrique E. , Anaissi Fauze J. 
Published: October 2022

The search for less expensive and viable products is always one of the challenges for research development. Commonly, the synthesis of coordination compounds involves expensive ligands, through expensive and low-yield routes, in addition to generating toxic and unusable residues. In this work, the organic ligand used is derived from the resin of a reforestation tree, Pinus elliottii var. elliottii. The synthesis method used Pinus resin and an aqueous solution of vanadium(III) chloride at a temperature of 80 °C. The procedure does not involve organic solvents and does not generate toxic residues, thus imparting the complex formation reaction a green chemistry character. The synthesis resulted in an unprecedented oxovanadium(IV)-bis(abietate) complex, which was characterized by mass spectrometry (MS), chemical analysis (CHN), vibrational (FTIR) and electronic spectra (VISIBLE), X-ray diffraction (XRD), and thermal analysis (TG/DTA). Colorimetric studies were performed according to the CIELAB color space. The structural formula found, consisted of a complex containing two abietate ligands, [VO(C20H29O2)2]. The VO(IV)-bis(abietate) complex was applied against microorganisms and showed promising results in antibacterial and antifungal activity. The best result of inhibitory action was against the strains of Gram-positive bacteria S. aureus and L. monocytogenes, with minimum inhibitory concentration (MIC) values of 62.5 and 125 μmol L−1, respectively. For Gram-negative strains the results were 500 μmol L−1 for E. coli; and 1000 μmol L−1 for Salmonella enterica Typhimurium. Antifungal activity was performed against Candida albicans, where the MIC was 15.62 μmol L−1, and for C. tropicalis it was 62.5 μmol L−1. According to the MFC analysis, the complex presented, in addition to the fungistatic action, a fungicidal action, as there was no growth of fungi on the plates tested. The results found for the tests demonstrate that the VO(IV)-bis(abietate) complex has great potential as an antimicrobial and mainly antifungal agent. In this way, the pigmented ink with antimicrobial activity could be used in environments with a potential risk of contamination, preventing the spread of microorganisms harmful to health.
Quality-adjusted life years for digital cognitive behavioural therapy for insomnia (Sleepio): a secondary analysis
Authors: Stokes Elizabeth A , Stott Richard , Henry Alasdair L , Espie Colin A , Miller Christopher B 
Published: October 2022

BackgroundInsomnia is common, and difficulty with daytime functioning is a core symptom. Studies show cognitive behavioural therapy (CBT) improves functioning, but evidence is needed on its value for money. Quality-adjusted life years (QALYs), capturing length and quality of life, provide a standard metric by which to judge whether a treatment is worth its cost. Studies have found QALY gains with therapist-delivered and therapist-guided CBT, but most have not reached statistical significance. Estimates of QALY gains with fully automated digital CBT (dCBT) for insomnia are lacking.AimTo assess whether dCBT (Sleepio) for insomnia is associated with gains in QALYs compared with a sleep hygiene education control.Design & settingA secondary analysis of a large effectiveness trial of 1711 participants from the UK, US, and Australia.MethodEQ-5D scores, the National Institute for Health and Care Excellence's (NICE’s) preferred measure of health-related quality of life (HRQoL), were predicted (mapped) from the 10-item Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health scores and used to determine QALYs from baseline to 24 weeks (controlled), and to 48 weeks (uncontrolled).ResultsAt week 24, QALYs were significantly higher for the dCBT group, with mean QALYs 0.375 and 0.362 in the dCBT and control groups, respectively. The mean difference was 0.014 (95% confidence interval [CI] = 0.008 to 0.019), and this difference was maintained over the 48-week study period (0.026, 95% CI = 0.016 to 0.036). The difference of 0.026 QALYs is equivalent to 9.5 days in perfect health.ConclusionSleepio is associated with statistically significant gains in QALYs over time compared with control. Findings may be used to power future studies and inform cost-effectiveness analyses of automated dCBT for insomnia scaled to a population level.
Improving the methodology for assessing the competitiveness of business structures in the furniture market
Authors: Bezrukova Tatyana , Korzhova O. 
Published: October 2022

Abstract
In our study discusses methods for assessing the competitiveness of goods: their types, essence and approach to each of them, existing shortcomings. In the center is of the consideration of each method based on the analysis and accuracy of the assessment, and attention is also drawn to the lack of a unified approach to assessment and the problem with its development. In today's market conditions, business structures that produce goods or services cannot constantly maintain their market positions, so increasing productivity and keeping it at a high level is very important. Competition acts as the highest motivating force that forces business structures to improve the quality of their products, goods, works or services, reduce production costs, and increase labor productivity. The means of competition are the goods and services by which competing firms seek to win recognition and get money from the consumer. In this regard, business structures in the furniture market need to investigate the impact of globalization and solve the problems of managing competitiveness and direct the results obtained to solve the primary tasks set for the industry on a digital development path. The competitiveness of business structures in the furniture market is their ability to successfully compete in the market and receive economic profit relative to competitors. The survival of business structures in a competitive, unstable and changeable external environment should be based on a constant and comprehensive analysis of the activities of competitors, their own strategic potential and evaluation of the effectiveness of its use, as well as a real assessment of the position of the business structure in the market for goods and services relative to competitors, i. e. an objective assessment of the competitiveness of the business structure. That is why there are many methods and techniques for increasing the competitiveness of a business structure. In the course of the study, methods of structural, systemic and functional analysis, graphical and mathematical methods, survey and questioning methods were used.
INFLUENCE OF INITIAL MOISTURE CONTENT OF WHEAT-TRITICALE GRAIN MIXTURE IN THE RATIO 50/50% ON YIELD OF WHOLE WHEAT-TRITICALE GROATS
Authors: Кандроков Р. Х. , Бекшокова П. А. , Ерина Ю. С. 
Published: October 2022

Разработка технологий получения новых продуктов питания на возобновляемой зерновой основе является одной из приоритетных задач продовольственной доктрины Российской Федерации. Разработана технология получения целой пшенично-тритикалевой крупы из пшенично-тритикалевой зерновой смеси в результате трёхэтапного абразивного шелушения. Приведены результаты исследований влияния исходной влажности пшенично-тритикалевой зерновой смеси в соотношении 50/50% на выход целой пшенично-тритикалевой крупы. Установлено, что наибольший выход целой пшенично-тритикалевой крупы в количестве 62,6% получается при минимальной начальной влажности пшенично-тритикалевой зерновой смеси равной 11,0%. При этом на первом этапе абразивного шелушения пшенично-тритикалевой зерновой смеси удалили 20,8% оболочек в течение 90 секунд, на втором этапе абразивного шелушения – 11,3% оболочек. Выявлено, что наименьший выход целой пшенично-тритикалевой крупы в количестве 59,2% получается при минимальной начальной влажности пшенично-тритикалевой зерновой смеси равной 14,3%. При этом на первом этапе абразивного шелушения пшенично-тритикалевой зерновой смеси удалили 22,5% оболочек в течение 90 секунд, на втором этапе абразивного шелушения удалили 12,4% оболочек.
The development of technologies for obtaining new food products on a renewable grain basis is one of the priority tasks of the food doctrine of the Russian Federation. A technology has been developed for producing whole wheat-triticale groats from wheat-triticale grain mixture as a result of three-stage abrasive peeling. The research results of influence of initial moisture content of wheat-triticale grain mixture in ratio 50/50% on yield of whole wheat-triticale groats are given. It was found that the highest yield of whole wheat-triticale groats in the amount of 62.6% is obtained at minimum initial moisture content of wheat-triticale cereal mixture equal to 11.0%. At the same time, at the first stage of abrasive peeling of wheat-triticale grain mixture 20.8% of shells were removed during 90 seconds, at the second stage of abrasive peeling – 11.3% of shells. It was revealed that the lowest yield of whole wheat-triticale groats in the amount of 59.2% is obtained with minimum initial moisture content of wheat-triticale cereal mixture equal to 14.3%. At the first stage of abrasive peeling of wheat-triticale grain mixture 22.5% of shells were removed during 90 seconds, at the second stage of abrasive peeling 12.4% of shells were removed.
Korelasi antara Neutrophil-To-Lymphocyte Ratio dengan Fraksi Ejeksi pada Pasien Penyakit Jantung Koroner: Studi di Sulawesi Utara, Indonesia
Authors: Pangemanan Janry A. , Panda Agnes L. , Polii Natalia C. I. , Bandana Victor , Posangi Ira , Sunardi Andrew E. P. , Cahyadi Singgih S. , Yofrido Filipus M. 
Published: October 2022

Abstract: Inflammation has a vital role in the pathogenesis of heart failure (HF) and coronary artery disease (CAD). Neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker proposed to have a correlation with ejection fraction (EF). This is a simple examination and can be obtained routinely in clinical practice. This study aimed to evaluate the correlation of NLR with EF in hospitalized patients with CAD. This was an observational and analytical study with a cross-sectional design. Samples were eligible CAD patients from May until August 2019 at Prof Dr. R. D. Kandou Hospital in North Sulawesi. All patients underwent echocardiography for EF calculation, and blood examination for NLR measurement and risk factor screening. The patients were treated according to the guideline. Data were analyzed using the Spearman test in SPSS v26. The results showed that the majority of patients were male (70.2%) with mean age of 60 years old. Hypertension was found in 76.6% and smoking history in 51.1% patients. NLR was shown to have a significance correlation with EF in patients with CAD (p=0.014). In conclusion, NLR has a significant correlation with EF. Moreover, it could be a useful tool for the clinicians to predict heart failure in a specific population. Keywords: neutrophil-to-lymphocyte ratio; ejection fraction; heart failure; coronary artery disease. Abstrak: Peradangan memiliki peran penting dalam patogenesis gagal jantung (HF) dan juga penyakit arteri koroner (CAD). Rasio neutrofil-limfosit (NLR) merupakan penanda inflamasi yang diduga berkorelasi dengan fraksi ejeksi (EF), serta merupakan pemeriksaan sederhana yang dapat diperoleh secara rutin dalam praktik klinis. Penelitian ini bertujuan untuk mengetahui korelasi NLR dengan EF pada pasien rawat inap dengan CAD. Jenis penelitian ialah observasional analitik dengan desain potong lintang. Sampel penelitian ialah pasien CAD yang memenuhi syarat dirawat dari bulan Mei hingga Agustus 2019 di Rumah Sakit Prof Dr. R. D. Kandou, Sulawesi Utara. Pasien diperiksakan dengan ekokardiografi untuk perhitungan EF, dan dilakukan pemeriksaan darah untuk penilaian NLR dan skrining faktor risiko. Semua pasien dirawat sesuai dengan pedoman. Data dianalisis menggunakan uji Spearman dengan SPSS v26. Hasil penelitian mendapatkan mayoritas sampel ialah laki-laki (70,2%) dengan usia rerata 60 tahun. Hipertensi ditemukan pada 76,6% dan riwayat merokok pada 51,1% pasien. NLR terbukti memiliki korelasi bermakna dengan EF pada pasien CAD (p=0,014). Simpulan penelitian ini ialah NLR terbukti memiliki korelasi bermakna dengan EF pada pasien CAD. Selain itu NLR dapat menjadi alat bantu yang berguna bagi klinisi untuk memrediksi gagal jantung pada populasi tertentu.Kata kunci: neutrophil-to-lymphocyte ratio; fraksi ejeksi; gagal jantung; penyakit arteri koroner
Meningkatkan Keterampilan Menulis Descriptive Text Dengan Membuat Poster
Authors: Maskanah Maskanah 
Published: October 2022

Tujuan penelitian tindakan kelas adalah: 1) meningkatkan keterampilan menulis teks deskripsi (descriptive text) dalam bahasa Inggris dengan pembelajaran berbasis proyek; dan 2) melakukan penilaian keterampilan teks deskripsi (descriptive text) dengan membuat poster bagi peserta didik kelas VIII F SMP N 3 Demak. Metode pembelajaran yang dipilih adalah pembelajaran Berbasis Proyek (Project Based Learning) dengan langkah-langkah: 1) penentuan proyek pembuatan poster, 2) penyusunan langkah-langkah membuat poster, 3) membuat poster dengan fasilitasi dan monitoring oleh guru, 4) presentasi/publikasi hasil poster dan 5) evaluasi poster hasil proyek. Penilaian yang dilakukan adalah penilaian keterampilan, dengan indikator penilaian: 1) vocabulary (kosa kata) yang digunakan; 2) content (isi poster); 3) writing style (gaya tulisan); 4) grammar (gaya bahasa); dan 5) hasil proyek berupa poster.Hasil Penelitian dari siklus I ke siklua II; instrumen Vocabulary terjadi penurunan pada kategori kurang 60% menjadi 0% dan terjadi kenaikan pada kategori cukup 40 % menjadi 66,7% dan kategori bagus/sangat bagus dari 0% menjadi 33,3%. Content (isi) terjadi penurunan pada kategori kurang 73,3% menjadi 6,7% dan terjadi kenaikan pada kategori cukup 26,7 % menjadi 60% dan kategori bagus dari 0% menjadi 33,3%. Writing Style (Gaya menulis) terjadi penurunan pada kategori kurang 50% menjadi 10% dan terjadi kenaikan pada kategori cukup 40 % menjadi 66,7% dan kategori bagus dari 0% menjadi 33,3%. Grammar (gaya Bahasa) terjadi penurunan pada kategori kurang 66,7% menjadi 10% dan terjadi kenaikan pada kategori cukup dari 33,3 % menjadi 56,7% dan kategori bagus 0% menjadi 33,3%. Hasil Proyek/Poster terjadi penurunan kategori kurang dari 46% menjadi 0% dan cukup 50 % menjadi 33,3% dan kategori bagus/sangat bagus terjadi kenaikan dari 3% menjadi 66,7%.
FAKTOR-FAKTOR YANG MEMPENGARUHI DINAMIKA KELOMPOK TANI PADI SAWAH (Oryza sativa L)
Authors: Kurnianto Bambang Tri , Lestari Mufida Diah 
Published: October 2022

ABSTRAK
Indonesia memiliki wilayah lahan pertanian yang luas dan memiliki iklim yang baik dan sangat sesuai dengan system pertanian. Sistem pertanian yang mempengaruhi sehingga menjadi fafktor penentuan keberhasilan sebuah agribisinis. Kelompok-kelompok tani yang dapat memberikan kontribusi cukup signifikan akan keberhasilan dalam keberhasilan petani padi sawah khususnya di Desa Tunggangri Kecamatan Kalidawir Kabupaten Tulungagung. Tujuan penelitian ini adalah menganalisis factor internal dan eksternal apa saja yang berpengaruh dengan dinamika kelompok tani padi sawah. Faktor-faktor yang mempengaruhi dinamika kelompok tani padi sawah (Oryza sativa L) seluruh variable berpengaruh dengan dinamika kelompok tani padi sawah dan secara parsial luas lahan berpengaruh nyata dengan dinamika kelompok padi sawah. Untuk umur, jumlah anggota, keluarga, tingkat Pendidikan, lama berusahatani, insitas penyuluhan, lama berusahatani, insitas penyuluhan dan ketersediaan sarana produksi tidak begitu berpengaruh nyata degan dinamika kelompok tani padi sawah.
Kata Kunci : padi sawah, kelompok tani, dinamika kelompok tani