bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of product touch information and sale proneness on consumers' responses to price discounts
Authors: Yazdanparast Atefeh , Kukar‐Kinney Monika 
Published: November 2022

AbstractSince price discounts are costly and can negatively affect consumers' perceptions of quality, it is crucial to identify the factors that make them effective in stimulating purchase behavior. Drawing on cue utilization theory, we examine price discount effectiveness in affecting consumers' reliance on the sale cue based on the provided product touch information as an intrinsic cue and individual consumer differences in sale proneness. Two experimental studies indicate that price discount information, product touch information, and sale proneness interact to determine consumers' responses. Perceived quality is the underlying mechanism behind the observed effects. For nonsale‐prone consumers, product touch information favorably influences responses to large price discounts by addressing product quality concerns and enhancing purchase confidence, but has no effect for regularly priced or low discounted products. For sale‐prone consumers, product touch information is not effective in increasing their responses regardless of the discount size. A qualitative study provides support for these results and highlights the role of perceived quality and purchase confidence. The research contributes to behavioral pricing, cue utilization theory, and sensory marketing and suggests that marketing managers should provide consumers with product touch information when implementing high discounts for products for which prepurchase touch is important.
Construction of Porous Polyureas and Polyamides via Domino Polymerization and Their High‐Efficiency Au(III) Adsorption
Authors: Lei Yujie , Xia Yunxia , Chen Wangzhi , Lin Bo , Li Tiesheng , Li Lei 
Published: November 2022

AbstractThe adoption of new synthesis strategy and monomers significantly promotes the construction of porous organic polymers (POPs) and their promising applications. A fabricating method of porous polyimides is developed via sequential imidization and cross‐linking reaction among self‐condensable building blocks, as reported in the authors' previous manuscript. Herein, porous polyureas (A‐POPs) are prepared starting from 4‐ethynylaniline and diisocyanate monomers, while porous polyamides (B‐POPs) are synthesized from 4‐ethynylbenzoic acid and diisocyanate monomers. It is found that decreasing the monomer content in solvent can effectively inhibit the premature phase separation and facilitate the evolution of integrated network. Eventually, a maximum surface area of 425 m2 g−1 is achieved for porous polyureas when the content of monomers is 10%. To the best knowledge, A‐POPs are the porous polyureas with the highest surface areas reported up to now. The as‐prepared porous polyurea (AN‐POP) exhibits the maximum adsorption capacity of 1093.87 ± 5.23 mg g−1 and removal rate of 99.96% for Au(III), due to its high surface area and the coordination between the heteroatoms (N and O) in A‐POPs and metal ions. Besides, the porous polyurea also exhibits excellent renewable efficiency and high selectivity to Au(III).
Morpho‐Functional Changes of Nigral Dopamine Neurons in an α‐Synuclein Model of Parkinson's Disease
Authors: Ledonne Ada , Massaro Cenere Mariangela , Paldino Emanuela , D'Angelo Vincenza , D'Addario Sebastian Luca , Casadei Nicolas , Nobili Annalisa , Berretta Nicola , Fusco Francesca R. , Ventura Rossella , Sancesario Giuseppe , Guatteo Ezia , Mercuri Nicola Biagio 
Published: November 2022

AbstractBackgroundThe accumulation of α‐synuclein (α‐syn) fibrils in intraneuronal inclusions called Lewy bodies and Lewy neurites is a pathological signature of Parkinson's disease (PD). Although several aspects linked to α‐syn–dependent pathology (concerning its spreading, aggregation, and activation of inflammatory and neurodegenerative processes) have been under intense investigation, less attention has been devoted to the real impact of α‐syn overexpression on structural and functional properties of substantia nigra pars compacta (SNpc) dopamine (DA) neurons, particularly at tardive stages of α‐syn buildup, despite this has obvious relevance to comprehending mechanisms beyond PD progression.ObjectivesWe aimed to determine the consequences of a prolonged α‐syn overexpression on somatodendritic morphology and functions of SNpc DA neurons.MethodsWe performed immunohistochemistry, stereological DA cell counts, analyses of dendritic arborization, ex vivo patch‐clamp recordings, and in vivo DA microdialysis measurements in a 12‐ to 13‐month‐old transgenic rat model overexpressing the full‐length human α‐syn (Snca+/+) and age‐matched wild‐type rats.ResultsAged Snca+/+ rats have mild loss of SNpc DA neurons and decreased basal DA levels in the SN. Residual nigral DA neurons display smaller soma and compromised dendritic arborization and, in parallel, increased firing activity, switch in firing mode, and hyperexcitability associated with hypofunction of fast activating/inactivating voltage‐gated K+ channels and Ca2+‐ and voltage‐activated large conductance K+ channels. These intrinsic currents underlie the repolarization/afterhyperpolarization phase of action potentials, thus affecting neuronal excitability.ConclusionsBesides clarifying α‐syn–induced pathological landmarks, such evidence reveals compensatory functional mechanisms that nigral DA neurons could adopt during PD progression to counteract neurodegeneration. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Evaluation of X chromosome inactivation in endemic Tunisian pemphigus foliaceus
Authors: Abida Olfa , Elloumi Nesrine , Bahloul Emna , Hachicha Hend , Sellami Khadija , Fakhfakh Raouia , Marzouk Sameh , Ben Ayed Ikhlas , Mahfoudh Nadia , Turki Hamida , Masmoudi Hatem 
Published: November 2022

AbstractBackgroundAlmost 5% of the world's population develops an autoimmune disease (AID), it is considered the fourth leading cause of disability for women, who represent 78% of cases. The sex ratio when it comes to the most prevalent AID varies from 9:1 in systemic lupus erythematosus (SLE) to 13:1 in endemic Tunisian pemphigus foliaceus (PF).MethodsTo test the potential involvement of skewed x‐inactivation in the pathogenesis of Tunisian PF, we analyzed the methylation status of a highly polymorphic CAG repeat in the androgen receptor gene and evaluated the x chromosome inactivation (XCI) patterns in peripheral blood‐leukocyte‐derived DNA samples of female patients with PF (n = 98) compared to healthy control (HC) subjects (n = 150), as well as female patients with SLE (n = 98) were enrolled as a reference group.ResultsXCI status was informative for 50 of the 98 PF patients (51%) and 70 of the 150 HC women (47%). Extremely skewed XCI patterns were more frequent in PF and SLEwomen than HC, but the difference was statistically significant only in women with SLE. No statistical difference was observed in XCI patterns between PF and SLE patients. PF phenotype‐XCI correlation analysis revealed that (i) skewed XCI patterns may be involved in the disease's subtype and (ii) it was more pronounced in the endemic group than the sporadic one. Furthermore, preferential XCI showed an increase in heterozygote genotypes of PF's susceptibility polymorphisms in immunity‐related X genes (FOXP3, AR, and TLR7) in PF patients compared to HC.ConclusionOur results suggest that skewed XCI could lead to hemizygosity of X‐linked alleles that might unmask X‐linked deleterious alleles.
Spectral analysis of an even order differential operator with square integrable potential
Authors: Polyakov Dmitry M. 
Published: November 2022

By using the method of similar operators, we study an even order differential operator with periodic, antiperiodic, and Dirichlet boundary conditions. We obtain eigenvalue asymptotics of this operator and estimates for its spectral decompositions and spectral projections. We also describe the asymptotic behavior of the corresponding analytic semigroup of operators.
Repeatability assessment for simultaneous measurement of arterial blood flow, venous oxygen saturation, and muscle perfusion following dynamic exercise
Authors: Mahmud Sultan Z. , Bashir Adil 
Published: November 2022

AbstractThe purpose of the present study was to demonstrate a new sequence and determine the repeatability of simultaneous dynamic measurements of blood flow, venous oxygen saturation (SvO2), and relative perfusion (change from resting perfusion) in calf muscle during recovery from plantar flexion exercise. The feasibility of near simultaneous measurement of bio‐energetic parameters was also demonstrated. A sequence was developed to simultaneously measure arterial blood flow using flow‐encoded projection, SvO2 using susceptibility‐based oximetry, and relative perfusion using arterial spin labeling in combination with dynamic plantar flexion exercise. The parameters were determined at rest and during recovery from single leg plantar flexion exercise. Test–retest repeatability was analyzed using Bland–Altman analysis and intraclass correlation coefficients (ICC). The mitochondrial capacity of skeletal muscle was also measured immediately afterwards with dynamic phosphorus magnetic resonance spectroscopy. Eight healthy subjects participated in the study for test–retest repeatability. Popliteal artery blood flow at rest was 1.79 ± 0.58 ml/s and increased to 11.18 ± 3.02 ml/s immediately after exercise. Popliteal vein SvO2 decreased to 45.93% ± 6.5% from a resting value of 70.46% ± 4.76% following exercise. Relative perfusion (change from rest value) was 51.83 ± 15.00 ml/100 g/min at the cessation of exercise. The recovery of blood flow and SvO2 was modeled as a single exponential with time constants of 38.03 ± 6.91 and 71.19 ± 14.53 s, respectively. All the measured parameters exhibited good repeatability with ICC ranging from 0.8 to 0.95. Bioenergetics measurements were within normal range, demonstrating the feasibility of near simultaneous measurement of hemodynamic and energetic parameters. Clinical feasibility was assessed with Barth syndrome patients, demonstrating reduced oxygen extraction from the blood and reduced mitochondrial oxidative capacity compared with healthy controls. The proposed protocol allows rapid imaging of multiple parameters in skeletal muscle that might be affected in disease.
An integrative review of supportive relationships between child‐bearing women and midwives
Authors: Almorbaty Hadeer , Ebert Lyn , Dowse Eileen , Chan Sally Wai‐Chi 
Published: November 2022

AbstractAimsTo review and evaluate the literature on the factors related to developing supportive relationships between women and midwives, including facilitators and barriers.DesignAn integrative review.MethodThe search used CINAHL, MEDLINE, Embase, EMcare, Maternity and Infant Care, PsycINFO, and Google Scholar from January 2009–June 2020. Two reviewers screened the eligible studies, and 2,399 records were identified. Quality was assessed with the mixed methods appraisal tool, and 14 articles were included.ResultsThe findings highlight that successful relationships require therapeutic communication, trust, respect, partnership, and shared decision‐making. Supportive relationships improve women′s satisfaction and birth outcomes, and continuity of care model is an enabling factor. Further research is required to understand supportive relationships in non‐continuity of care models and when different cultural backgrounds exist.
Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration
Authors: van der Beek Justine N. , Artunduaga Maddy , Schenk Jens‐Peter , Eklund Meryle J. , Smith Ethan A. , Lederman Henrique M. , Warwick Anne B. , Littooij Annemieke S. , Khanna Geetika 
Published: November 2022

AbstractMalignant renal tumors are rare in children, and Wilms tumors (WTs) are the most common subtype. Imaging plays an essential role in the diagnosis, staging, and follow‐up of these patients. Initial workup for staging is mainly performed by cross‐sectional imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). Imaging approach within the two core international groups, the Children's Oncology Group (COG, North America) and the International Society of Pediatric Oncology ‐ Renal Tumor Study Group (SIOP‐RTSG, Europe), differs. Whereas abdominal ultrasound (US) is used for the initial diagnosis of a suspected pediatric renal tumor globally, COG protocols support the use of CT or MRI for locoregional staging, contrary to the preference for MRI over CT for abdominopelvic evaluation within the SIOP‐RTSG. The purpose of this manuscript is to summarize current imaging approaches, highlighting differences and similarities within these core international groups, while focusing on future innovative efforts and collaboration within the HARMONICA initiative.
Enhanced mechanical and thermal properties of carbon fiber‐reinforced thermoplastic copoly(phthalazinone ether sulfone ketone) composites
Authors: Wang Bing , Li Nan , Fu Xin , Cheng Shan , Zhao Na , Zhang Jiazi , Hu Fangyuan , Bao Qingguang , Hao Haoyue , Jian Xigao 
Published: November 2022

AbstractThis paper presented a facile and effective way to modify copoly(phthalazinone ether sulfone ketone) (PPBESK) resin with SiC nanowires (SiC NWs) to improve the mechanical and thermal properties of CF/PPBESK composites. The results showed that linear SiC NWs with a diameter of about 3 μm and length of about 100 μm were uniformly incorporated into the composite, which greatly enhanced the toughness of the PPBESK resin and the interfacial performance between the CF and PPBESK. Compared with the untreated composites, the ILSS, compressive strength, flexural strength, and through‐thickness thermal conductivity of the SiC NWs treated composites increased by 12.3%, 31.7%, 15.0%, and 40.7%, respectively. In addition, the thermal effusivity of SiC NWs treated composites was also ameliorated. These results will provide a feasible approach for the fabrication of structurally functionally integrated composites.
High‐dimensional propensity scores for empirical covariate selection in secondary database studies: Planning, implementation, and reporting
Authors: Rassen Jeremy A. , Blin Patrick , Kloss Sebastian , Neugebauer Romain S. , Platt Robert W. , Pottegård Anton , Schneeweiss Sebastian , Toh Sengwee 
Published: November 2022

AbstractReal‐world evidence used for regulatory, payer, and clinical decision‐making requires principled epidemiology in design and analysis, applying methods to minimize confounding given the lack of randomization. One technique to deal with potential confounding is propensity score (PS) analysis, which allows for the adjustment for measured preexposure covariates. Since its first publication in 2009, the high‐dimensional propensity score (hdPS) method has emerged as an approach that extends traditional PS covariate selection to include large numbers of covariates that may reduce confounding bias in the analysis of healthcare databases. hdPS is an automated, data‐driven analytic approach for covariate selection that empirically identifies preexposure variables and proxies to include in the PS model. This article provides an overview of the hdPS approach and recommendations on the planning, implementation, and reporting of hdPS used for causal treatment‐effect estimations in longitudinal healthcare databases. We supply a checklist with key considerations as a supportive decision tool to aid investigators in the implementation and transparent reporting of hdPS techniques, and to aid decision‐makers unfamiliar with hdPS in the understanding and interpretation of studies employing this approach. This article is endorsed by the International Society for Pharmacoepidemiology.
Exploring the role of m6A modification in cancer
Authors: Wei Yongqi , Li Yin , Lu Chunlai 
Published: November 2022

Abstractm6A is one of the most common, abundant, and conserved post‐transcriptional modifications that regulate broad biological processes in the human body through m6A regulators. m6A regulators are figuratively classified according to their functions: writers, erasers, and readers, which can methylate RNAs, demethylate RNAs, and recognize RNA m6A sites, consequently affecting RNA fate. Tumors are an essential class of diseases that threaten human health, and as the study of m6A modification in tumors continues to advance, more and more relevant studies are emerging. In this review, we overview the recent studies of m6A in various types of tumors to demonstrate the role of m6A modification in providing a vision in diagnosing and treating tumors.
Sometimes faster can be better: Microneedling IPG strips enables higher throughput for integrative top‐down proteomics
Authors: Carbonara Katrina , Coorssen Jens R. 
Published: November 2022

AbstractPassive rehydration of immobilized pH gradient (IPG) strips for two‐dimensional gel electrophoresis (2DE) has, to our knowledge, never been quantitatively evaluated to determine an ideal rehydration time. Seeking to increase throughput without sacrificing analytical rigor, we report that a substantially shorter rehydration time is accomplished when surface area of IPG strips is increased via microneedling. Rehydration for 4 h, post microneedling, provides comparable results to overnight rehydration in final analyses by 2DE, while also shortening the overall protocol by 1 day.
A facile and versatile strategy for synthesis of dopamine‐functionalized polymers
Authors: Wang Ruosi , Sun Mengxiao , Wang Chenyu , Dong Anjie , Zhang Jianhua 
Published: November 2022

AbstractMussel‐inspired biomimetic dopamine (DA)‐functionalized polymers have been widely studied and applied in many fields, such as biological adhesives, surface modification and biomedicine. However, the current preparation methods still face challenging obstacles, such as complex multistep processes, harsh reaction conditions and relatively low yield. Herein, a facile, efficient and versatile strategy was designed to synthesize DA‐functionalized polymers by epoxy‐amino click reaction between DA and epoxy‐containing polymers derived from readily available commercial monomer glycidyl methacrylate (GMA). A series of DA‐functionalized polymers were successfully prepared and their structure and composition were fully characterized. In addition, the performance for adhesion and surface modification of obtained DA‐functionalized polymers was evaluated. The results indicated this novel synthetical strategy can readily prepare DA‐functionalized polymers in a highly simple and controllable manner. Moreover, the DA‐functionalized polymers prepared by epoxy‐amino click reaction possessed an enhanced performance for adhesiveness. Considering the universality, simplicity and high controllability of this methodology as well as the readily available raw materials, this strategy provides new opportunities for scale‐up production of DA‐functionalized polymers with tunable DA content for various applications.
Case report of a pediatric Chinese cystic fibrosis patient with the c.1521_1523delCTT/c.3874‐4522A>G genotype
Authors: Su Yanyan , Tang Yu , Tang Xiaolei , Shen Yuelin 
Published: November 2022

AbstractThis report describes a case of an 11‐year‐old Chinese boy with cystic fibrosis (CF) bearing the c.1521_1523delCTT/c.3874‐4522A>G genotype, an extremely rare CF genotype in the Chinese population. Notably, the deep intron mutation c.3874‐4522A>G, which has mainly been reported in patients with phenotypically mild CF, is identified here for the first time in a Chinese patient with severe CF. In the case discussed here, the c.3874‐4522A>G mutation was associated with severe pulmonary disease with early symptoms onset, progressive bronchiectasis, recurrent airway infection with both Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus, rapid decline of lung function and poor weight gain. Despite intensive hospital‐based pulmonary care and optimized therapy, the child died of cardiopulmonary failure 3 months after discharge.
Ramsey goodness of trees in random graphs
Authors: Araújo Pedro , Moreira Luiz , Pavez‐Signé Matías 
Published: November 2022

AbstractFor graphs and a family of graphs , we write to denote that every blue‐red coloring of the edges of contains either a blue copy of , or a red copy of each . For integers and , let denote the family of all trees with edges and maximum degree at most . We prove that for each , there exist constants such that if and , then
with high probability. This is a random version of a well‐known result of Chvátal from 1977. The proof combines a stability argument with the embedding of trees in expander graphs. Furthermore, the proof of the stability result is based on a sparse random analogue of the Erdős–Sós conjecture for trees with linear size and bounded maximum degree, which may be of independent interest.
Application of a Rapid In Vitro Method Based on Glucometer for Determination of Starch Digestibility and Estimated Glycemic Index in Rice
Authors: Srikaeo Khongsak 
Published: November 2022

AbstractMeasuring the glycemic index (GI) of rice in vivo is time consuming and costly. A simple, reliable, and cost‐effective in vitro digestion assay suitable for use during rice breeding and rice product development is required. The purpose of this study is to propose the use of an in vitro enzymatic starch digestion assay based on a glucometer to determine the estimated GI (eGI) of rice in both raw and cooked forms. Four rice cultivars differing in amylose contents are examined. The known GI rice cultivar, Doongara, is used as the reference. The assay includes the digestion of ground rice using all of the enzymes require to simulate the human digestive tract. The glucose released during digestion is determined using a portable hand‐held glucometer over a 120‐min period. The obtained starch digestograms are modeled using a first‐order kinetic model, and eGI values are calculated. The assay is applicable to both raw and cooked rice samples. It can be used to classify rice according to its eGI as affected by cultivars and cooking methods. The protocol is robust, high‐throughput, and adaptable to non‐laboratory settings. It can benefit rice breeders, farmers, and manufacturers of rice products.
Exposure to copper activates mitophagy and endoplasmic reticulum stress‐mediated apoptosis in chicken (Gallus gallus) cerebrum
Authors: Huo Yihui , Ma Feiyang , Li Tingyu , Lei Chaiqin , Liao Jianzhao , Han Qingyue , Li Ying , Pan Jiaqiang , Hu Lianmei , Guo Jianying , Tang Zhaoxin 
Published: November 2022

AbstractA large amount of copper (Cu) used in production activities can lead to the enrichment of Cu in the environment, which can cause toxicity to animals. However, the toxicity mechanism of Cu on the cerebrum is still uncertain. Hence, a total of 240 chickens were separated into four groups in this study to reveal the potential connection between mitophagy and endoplasmic reticulum (ER) stress‐mediated apoptosis in the chicken cerebrum in the case of excess Cu exposure. The cu exposure situation was simulated by diets containing various levels of copper (11 mg/kg, control group; 110 mg/kg, group I; 220 mg/kg, group II and 330 mg/kg, group III) for 49 days. The results of histology showed that vacuolar degeneration was observed in the treated groups, and the mitochondria swell and autophagosomes formation were found under excess Cu treatment. Additionally, the expression of mitophagy (PINK1, Parkin, LC3I, LC3II and p62) and ER stress (GRP78, PERK, ATF6, IRE1α, XBP1, CHOP, and JNK) indexes were significantly upregulated under excess Cu exposure. Furthermore, the mRNA and protein expression of Bcl‐2 were decreased, while Bak1, Bax, Caspase12, and Caspase3 were increased compared to the control group. In summary, this study demonstrated that an overdose of Cu could induce mitophagy and ER stress‐mediated apoptosis in the chicken cerebrum. These findings revealed an important potential connection between Cu toxicity and cerebrum damage, which provided a new insight into Cu neurotoxicity.