bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELATIONSHIP BETWEEN WORK POSTURE AND REPETITIVE MOVEMENTS WITH COMPLAINTS OF CARPAL TUNNEL SYNDROME (CTS) ON STONE-BREAKING WORKERS ON THE BANKS OF THE KALISETAIL RIVER. SETAIL VILLAGE, GENTENG DISTRICT, BANYUWANGI REGENCY
Authors: Kumalasari Ulviana Dewi , Dwiyanti Endang 
Published: September 2022

ABSTRACT
Background: Workers who perform repetitive movements and work in a manner that remains seated for a long time experience Carpal Tunnel Syndrome in stone-breaking workers. It can reduce worker productivity because CTS can cause disability. Objective: Analyzing the relationship between work posture and repetitive movements with Carpal Tunnel Syndrome in stone-breaking workers on the banks of the Kalisetail River, Genteng District, Banyuwangi Regency. Method: This study was included in an observational analytic study with a cross-sectional research design. The samples in this study were all stone-breaking workers, consisting of 30 people, along the Kalisetail River, Setail Village, Genteng District, and Banyuwangi Regency. Results: The results showed the relationship between work posture (r = 0.420) and repetitive movement (r = 0.671) with complaints of Carpal Tunnel Syndrome in stone-breaking workers on the banks of the Kalisetail River was sufficient or moderate until strong. Conclusion: This study concludes that the relationship between work posture and repetitive movements of Carpal Tunnel Syndrome was sufficient until strong in stone-breaking workers on the outskirts of Kalisetail River. The researcher suggests applying rest breaks or recovery times, physical exercise during break times, and workplace adjustment.
ABSTRAK
Latar Belakang: Pekerja yang melakukan gerakan repetitif dan bekerja dengan posisi tetap yaitu duduk dalam waktu yang lama merupakan penyebab terjadinya Carpal Tunnel Syndrome pada pekerja pemecah batu. Hal ini dapat menurunkan produktivitas pekerja karena CTS dapat menimbulkan kecacatan. Tujuan: Menganalisis hubungan antara postur kerja dan gerakan repetitif dengan Carpal Tunnel Syndrome pada pekerja pemecah batu di pinggiran Sungai Kalisetail Kecamatan Genteng Kabupaten Banyuwangi. Metode: Penelitian ini termasuk dalam penelitian analitik observasional dengan desain penelitian cross sectional. Sampel dalam penelitian ini adalah semua populasi pekerja pemecah batu di sepanjang Sungai Kalisetail Desa Setail, Kecamatan Genteng, Kabupaten Banyuwangi sebanyak 30 orang. Hasil: Hasil penelitian menunjukkan bahwa hubungan antara postur kerja (r=0,420 dan gerakan repetitif (r=0,671) dengan keluhan Carpal Tunnel Syndrome pada pekerja pemecah batu di pinggiran Sungai Kalisetail adalah cukup atau sedang sampai kuat. Kesimpulan dari penelitian ini adalah hubungan antara postur kerja dan gerakan repetitif dengan keluhan Carpal Tunnel Syndrome adalah cukup atau sedang sampai kuat pada pekerja pemecah batu di pinggiran Sungai Kalisetail Kecamatan Genteng Kabupaten Banyuwangi. Saran peneliti adalah penerapan jeda istirahat atau waktu pemulihan, latihan fisik di sela waktu istirahat, dan penyesuaian tempat kerja.
Diversity and Inclusion in Orthopaedic Surgery from Medical School to Practice
Authors: Lamanna Daniel L. , Chen Antonia F. , Dyer George S.M. , Johnson Anthony E. , McCarthy Colm J. 
Published: September 2022

Abstract:
Orthopaedic surgery has historically been one of the least diverse fields in medicine in the U.S. Despite having been declared a critical issue by the American Orthopaedic Association, a lack of diversity and inclusion across all metrics remains a persistent problem. In order to balance representation within orthopaedic surgery, a multiyear and multilevel approach should be considered across the life cycle of a surgeon. Talented individuals from diverse backgrounds must be identified and given early exposure to orthopaedic surgery. They must be nurtured, mentored, and retained. Representation at the medical student, resident, and faculty level is vital to ensuring diversity across the next generation of surgeons.
We cannot alter representation within orthopaedics unless we broaden the candidate selection pool. Medical school classes provide the selection pool for residency, residency provides the candidates for fellowship, fellowships provide the candidates for employment, and employment provides the pool for promotion to leadership positions. Through each progression, there is a loss of underrepresented applicants, which leads to a lack of balanced representation in orthopaedic surgery. With stronger efforts to identify and retain individuals at each phase of a surgeon’s career, we hope to mitigate the loss of talented and diverse individuals from this field.
We challenge the paradigm of increasing diversity that focuses only on the resident selection level. Instead, efforts must begin at the medical student level. Efforts for early and meaningful exposure to the field through a musculoskeletal curriculum and rotations as well as connection through mentorship and sponsorship are vital for retention. At each ascending level of education, reinvestment in each individual is critical. Exposure, mentorship, retention, and promotion should lead to a more diverse and rich future. To achieve this, deliberate and longitudinal action should be instituted to increase diversity within orthopaedics.
The effects of abscisic acid administration in PCOS rat model and H202 induced human granulosa cell damage: A preliminary investigation
Authors: Xie Yidong , Li Xiaohong , Guo Junliang , Xiao Li , Li Shangwei 
Published: September 2022

Abstract
Background
Polycystic ovary syndrome (PCOS) is commonly associated with metabolic disorders. Abscisic acid (ABA) is a phytohormone present in vegetables and fruits that can be naturally supplied by the dietary intake and has been previously studied for its benefits to human health, especially in diabetes people. It has been demonstrated that ABA plays a key role in glucose metabolism, inflammation, and tumor growth. The aim of this study was to investigate the therapeutic effect of ABA on letrozole-induced PCOS rats.
Materials and Methods
Wistar rats were implanted with letrozole-continuous-release pellets to induce a PCOS-like phenotype, subsequently treated with ABA or vehicle control. Bodyweight changes, Testosterone(T) level, fasting insulin measurements, and glucose tolerance tests have been investigated. A cell apoptosis model was established induced by H2O2. Cell viability was tested by cell counting Kit-8 (CCK-8). Cell apoptosis was tested by flow cytometry, and the oxidative stress state of cells was examined using ROS array.
Results
Body weights, glucose impairment, and T level were significantly improved in the ABA treated PCOS rat than in vehicle-treated control PCOS rats. ABA significantly reduced H2O2-induced KGNs cell apoptosis and ROS levels and increased cell viability.
Conclusion
The findings suggest that ABA could be a candidate adjunctive treatment for improving the insulin sensitivity and hyperandrogenemia of PCOS patients, and ameliorated H2O2-induced KGN cell apoptosis and oxidant stress.
Phenotypic and functional characterisation of locally produced natural killer cells ex vivo expanded with the K562-41BBL-mbIL21 cell line
Authors: Shman Tatsiana , Vashkevich Katsiaryna , Migas Aleksandr , Matveyenka Mikhail , Lasyukov Eugeniy , Muhametshina Anastasia , Horbach Katsiaryna , Aleinikova Olga 
Published: September 2022

Abstract
We characterise the expansion, phenotype and functional activity of natural killer (NK) cells obtained for a clinical trial.
Nineteen expansion procedures were performed to obtain NK cell products for 16 patients. NK cells were ex vivo expanded from haploidentical donor peripheral blood mononuclear cells in the presence of the locally generated feeder cell line K-562 with ectopic expression of 4-1BBL and mbIL-21.
The median duration of expansion was 18 days (range 14–25). The median number of live cells yielded was 2.26 × 109 (range 0.89–5.5 × 109) with an NK content of 96.6% (range 89.0%–98.8%). The median NK cell fold expansion was 224.7 (range 42–647). The majority of expanded NK cells had the phenotype of immature activated cells (NKG2A+, double bright CD56++CD16++, CD57-) expressing NKp30, NKp44, NKp46, NKG2D, CD69, HLA-DR and CD96. Despite the expression of exhaustion markers, expanded NK cells exhibited high cytolytic activity against leukaemia cell lines, high degranulation activity and production of cytokines. There was noted decreased functional activity of NK cells in tests against the patient’s blasts.
NK cells obtained by ex vivo expansion with locally generated K562-41BBL-mbIL21 cells have both a relatively undifferentiated phenotype and enhanced cytolytic activity against cancer cell lines. Expansion of NK cells with the feeder cells allows obtaining a sufficient quantity of the NK cell product to reach high cell doses or increase the frequency of cell infusions for adoptive immunotherapy. Registered at clinicaltrials.gov as NCT04327037.
Long-term survive of Aliarcobacter butzleri in two models symbiotic interaction with Acanthamoeba castellanii
Authors: Medina Gustavo A. , Flores-Martin Sandra N. , Pereira Wellison A. , Figueroa Elías G. , Guzmán Neftalí H. , Letelier Pablo J. , Andaur Marcela R. , Leyán Pilar I. , Boguen Rodrigo E. , Hernández Alfonso H. , Fernández Heriberto 
Published: September 2022

Abstract
Aliarcobacter butzleri (formerly known as Arcobacter butzleri) is an emerging foodborne zoonotic pathogen that establishes in vitro endosymbiotic relationships with Acanthamoeba castellanii, a free-living amoeba. Previously, we described that this bacterium acts as an endocytobiont of A. castellanii, surviving for at least 10 days in absence of bacterial replication. Thus, the aim of this study was to evaluate the ability of A. butzleri to survive as a long-term endosymbiont of A. castellanii for 30 days in two models of symbiotic interaction with A. castellanii: i) endosymbiotic culture followed by gentamicin protection assay and ii) transwell co-culture assay. The results allow us to conclude that A. butzleri is capable of surviving as an endosymbiont of A. castellanii for at least 30 days, without multiplying, under controlled laboratory conditions. In addition, in the absence of nutrients and as both microorganisms remain in the same culture, separated by semi-permeable membranes, A. castellanii does not promote the survival of A. butzleri, nor does it multiply. Our findings suggest that the greater survival capacity of A. butzleri is associated with their endosymbiont status inside A. castellanii, pointing out the complexity of this type of symbiotic relationship.
Social drivers of short stay market in a regional Australia: A local development perspective
Authors: Ndaguba Emeka , Brown Kerry , Marinova Dora , Jogulu Uma 
Published: September 2022

Abstract
Discourse on microentrepreneurs research on short stay accommodation was not in existence before 2008. After 2009, several concepts and constructs were developed and a few till date have been empirically tested, but a majority of those that have been tested relate to economics, leaving the social, cultural, and environmental perspective backward. Thus, this study aims to identify and assess social factors influencing short-stay market economy in a regional area. 16 interview sessions with 18 participants of a face-to-face interview conducted, and the Leximancer software was employed for its analysis. The study shows that the social drivers to SSA are not generic, but pluralistic, multidimensional, and dynamic, and that limiting regulatory clauses to borrowed concepts of limitation or prohibition, the council demonstrates a lack of digital leadership. Despite ample opportunities provided by SSM in regional area, there are few encumbrances that cannot be overlooked.
WITHDRAWN: Benchmarking Fitness Center Business Performance in Thailand: Efficiency Assessment with Data Envelopment Analysis
Authors: Chankuna Dittachai , Thanaiudompat Thanarit , Sukdee Thitipong 
Published: September 2022

Abstract
Fitness center business (FCB) in Thailand has increasing marketing value and economic impacts to sports industry for the last years. Despite the fact that, sport marketeers often enhance competitiveness by increases investment through various marketing strategies, efficiency never assessed. Data envelopment analysis (DEA) and then Tobit regression model were firstly applied in FCB for benchmarking their efficiency and helps entrepreneurs, marketeers, and scholars fulfil the management gap to investigated the influenced marketing factors affected to the FCB performance. 60 FCBs around Thailand was qualified the inclusion criteria to be a decision-making unit (DMU). Average efficiency score of DMUs is 0.9468, which consistent with empirical data that they survived after COVID-19 pandemic. Personal trainer standard, product development, and atmosphere and interior decoration are significantly influenced marketing factors affected to the FCB performance. We suggested that entrepreneur or marketeer should adopt personal trainer into marketing strategy for driving FCB performance.
The impact of micro-credit use on small-scale farmer’s income and expenditure Evidence from Raya kobo Woreda, Ethiopia
Authors: Tefera Abate Beleye , Awoke Agerwork Jejaw 
Published: September 2022

Abstract
Background
This study was fully conducted through primary data gained from 385 farm household heads. Those farm household heads were determined by Cochran sample size determination formula and three stage probability sampling was applied to select them. The collected data was analyzed through propensity score matching method of impact evaluation.
Result
The results of this study reveals that household income and expenditure was improved (10,934 ETB &1,705 ETB respectively) as the result of microcredit participation for the treated households.
Conclusion
Therefore any microfinance development intervention should include strategies on how to enrich and incorporate the microcredit participation of large number of small-scale farm households.
Scalable training of graph convolutional neural networks for fast and accurate predictions of HOMO-LUMO gap in molecules
Authors: Choi Jong Youl , Zhang Pei , Mehta Kshitij , Blanchard Andrew , Pasini Massimiliano Lupo 
Published: September 2022

Abstract
Graph Convolutional Neural Network (GCNN) is a popular class of deep learning (DL) models in material science to predict material properties from the graph representation of molecular structures. Training an accurate and comprehensive GCNN surrogate for molecular design requires large-scale graph datasets and is usually a time-consuming process. Recent advances in GPUs and distributed computing open a path to reduce the computational cost for GCNN training effectively. However, efficient utilization of high performance computing (HPC) resources for training requires simultaneously optimizing large-scale data management and scalable stochastic batched optimization techniques. In this work, we focus on building GCNN models on HPC systems to predict material properties of millions of molecules. We use HydraGNN, our in-house library for large-scale GCNN training, leveraging distributed data parallelism in PyTorch. We use ADIOS, a high-performance data management framework for efficient storage and reading of large molecular graph data. We perform parallel training on two open-source large-scale graph datasets to build a GCNN predictor for an important quantum property known as the HOMO-LUMO gap. We measure the scalability, accuracy, and convergence of our approach on two DOE supercomputers: the Summit supercomputer at the Oak Ridge Leadership Computing Facility (OLCF) and the Perlmutter system at the National Energy Research Scientific Computing Center (NERSC). We present our experimental results with HydraGNN showing i) reduction of data loading time up to 4.2 times compared with a conventional method and ii) linear scaling performance for training up to 1,024 GPUs on both Summit and Perlmutter.
Abnormal placentation: the necessity for preoperative magnetic resonance imaging
Authors: Huang Marilyn , Knickerbocker Angelica M. , Pon Fay F. , Castillo Rosa P , Galli Johnny H. , Maldonado-Puebla Marigloria , Paidas Michael , Ghulmiyyah Labib M , Sinno Abdulrahman K. 
Published: September 2022

Abstract

Background:Placenta accreta spectrum (PAS) is characterized by abnormal placental adherence that increases the risk of maternal hemorrhage and death. Current literature suggests lower rates of maternal morbidity and mortality when placenta accreta spectrum is diagnosed or suspected prenatally. We examined the use of preoperative imaging in predicting PAS with the goal of assessing concordance between imaging modalities and impact of differential imaging on morbidity.
Methods: Women with suspected placenta accreta spectrum who delivered at our institution from 2010-2018 were included. Perioperative diagnoses, imaging, and pathology reports were abstracted from medical records. Descriptive statistics, ANOVA, chi square, multinomial logistic regression, Cohen’s kappa analyses were performed.
Results: There were 152 cases with suspected placenta accreta spectrum from 2010-2018 with 131 (86.2%) cases confirmed by final pathology. Of the confirmed cases, there were 38 (25%) accretas, 62 (40.8%) incretas, and 31 (20.4%) percretas. Magnetic resonance imaging (MRI) more accurately diagnosed placenta accreta spectrum (39% of cases) than ultrasound (25%). Cohen’s kappa for ultrasound versus pathology was 0.02836, demonstrating slight inter-rater agreement (p=0.55) than 0.5087 in the MRI versus pathology group (p=0.08). Of the 107 patients requiring resuscitative blood products, indicators of morbidity, the percreta group had significantly greater mean estimated blood loss (4.8L) with longer mean length of hospital stay (p=0.014) compared to increta (3.1L) and accreta (2.6L) (p=0.04).
Conclusions: This study supports the role of pelvic magnetic resonance imaging for antepartum diagnosis of placenta accreta spectrum. Accurate diagnosis is essential for the perioperative coordination of care to improve maternal outcomes and reduce mortality.
The recalibration and redevelopment of a model to calculate patients’ probability of completing a colonoscopy following an abnormal fecal test
Authors: Petrik Amanda , Johnson Eric S. , Slaughter Matthew , Leo Michael C. , Thompson Jamie , Mummadi Raj , Jimenez Ricardo , Hussain Syed , Coronado Gloria 
Published: September 2022

Abstract
Background: Fecal immunochemical testing (FIT) is an effective screening tool for colorectal cancer. If a FIT is abnormal, a follow-up colonoscopy is necessary to remove polyps or find cancers. Identifying patients who have a low probability of obtaining follow-up colonoscopy after an abnormal fecal test could help deliver early interventions that increase colonoscopy adherence (e.g., patient navigation) to patients who need them most. We sought to develop a usable risk prediction model to identify patients unlikely to complete a colonoscopy following an abnormal FIT test.
Methods: We recalibrated and then redeveloped a prediction model created in a group of federally qualified health centers (FQHCs) to be used in a single large FQHC. The models were created from a retrospective cohort of patients aged 50-75 with an abnormal FIT test. The models used clinical data. Logistic and Cox regressions were used to recalibrate the group of FQHC prediction model and then redevelop it in the single large FQHC.
Results: The initial risk model used data from 8 FQHCs (26 clinics) and included eight variables including race, clinic system, prior missed appointments, insurance, prior flu shots, age, indication of anticoagulation use, and income inequality. The first model included 1723 patients. However, when we applied the model to a single large FQHC (34 clinics, n=884), the model did not recalibrate successfully (C-statistic dropped more than 0.05, from 0.66 to 0.61). The model was redeveloped in a cohort of 1401 patients and contained 12 variables including age, race, language, insurance, county, a composite variable for sex and mammogram screening, number of prior missed appointments, Gagne’s comorbidity score, number of prior encounters, BMI, marital status, and prior screening with a c-statistic of 0.65.
Conclusions: The original model developed in a group of FQHCs did not adequately recalibrate in the single large FQHC. Health system, patient or specialty care characteristics, or differences in data captured in the electronic health record may have led to the inability to recalibrate the model. However, the redeveloped model provides an adequate model for the single FQHC. Precision medicine is best applied when risk is understood in context and interventions are tailored for specific populations’ predictors.
Quality assessment of malaria microscopic diagnosis at the LPM-HALD of Dakar, Senegal, in 2020
Authors: GARBA Mamane Nassirou , DEME Awa Bineta , DIALLO Mamadou Alpha , DIEDHIOU Younous , MBAYE Amadou Mactar , DIA Mareme , SECK Anna , ZOUMAROU Daba , NDIAYE Yaye Die , NDIAYE Lamine , YADE Mamadou Samb , DIEYE Baba , SENE Aita , TINE Abdoulaye , TOURE Mariama , GADIAGA Nogaye , FALL Awa , NGOM Bassirou , SOW Djiby , NDIAYE Aliou , KEITA Astou , NDIAYE Mame Fama , GOMIS Jules François , DIOP Fatoumata , DIALLO Guete , NDIAYE Ibrahima Mbaye , BA Elhadj Meissa , BITEYE Omar , NDIAYE Cheikh , NDIAYE Pape Ousmane , GAYE Amy , SY Mouhamad , NDIAYE Tolla , DIONGUE Serigne Khadim , SECK Mame Cheikh , NDIAYE Mouhamadou , BADIANE Aida Sadikh , NDIAYE Daouda 
Published: September 2022

Abstract
Background: Following WHO guidelines, microscopy is the reference for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation. In this perspective, we proceeded to laboratory verification through assessing the performance of the laboratory by confirming the reliability and the accuracy of the results obtained in accordance with the requirements of the ISO 15189 standards. This study aimed to verify the method of microscopic diagnosis of malaria at the LPM, in the Aristide Le Dantec hospital (HALD) in Dakar, Senegal.
Methods: This is a validation/verification study conducted from June to August 2020. Twenty (20) microscopic slides of thick/thin smear with known parasite densities (PD) selected from the Cheick Anta Diop University malaria slide bank in Dakar were used for this assessment. Six (6) were used to assess readers' ability to determine PD and fourteen (14) were used for detection and identification of parasites. Four (4) LPM-HALD microscopists read and recorded their results on prepared sheets. Data analysis was done with Microsoft Excel 2010 software.
Results: Of these twenty (20) slides read, a 100% agreement was obtained on eight (8) slides. Four (4) out of the six (6) parasite density evaluation slides obtained a concordance of less than 50%. Thirteen (13) out of the fourteen (14) identification slides obtained a concordance greater than 50%. Only one (1) identification slide obtained zero agreement from the readers. On the other hand, for species identification it was noted a score greater than 80% and the PD obtained a score between 0.20 and 0.4. Readers obtained 100% precision, sensitivity, specificity and both negative and positive predictive values.
Conclusion: This work demonstrated that the microscopic method of malaria diagnosis used in the LPM/HALD are in accoradance with all the reliability required by ISO 15189.