bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Use of F2-Alpha Prostaglandins and NSAIDs in the Treatment of Glaucoma: Questions and Answers
Authors: Бездетко П.А. , Бездетко Н.В. , Мужичук Е.П. 
Published: February 2022

Медикаментозное лечение вызывает особый интерес на всех этапах менеджмента пациентов с глаукомой. Профиль безопасности и удобство применения выводят аналоги простагландинов (ПГ) F2-альфа на первый план при выборе гипотензивных препаратов в лечении первичной открытоугольной глаукомы. Но есть и проблемные вопросы, и связаны они с природой синтетических простагландинов, наличием в гипотензивных препаратах примеси провоспалительного ПГЕ. Именно эти обстоятельства ограничивают применение аналога ПГ F2-альфа у пациентов как с первичной, так и особенно со вторичной глаукомой. Вопрос о дополнительном применении нестероидных противовоспалительных препаратов (НПВП) в сочетании с синтетическими простагландинами для предотвращения побочных эффектов обсуждается в литературе, но однозначного ответа на этот вопрос нет. В связи с этим нами и были проведены исследования сравнения эффективности монотерапии латанопростом в классическом и бесконсервантном вариантах и комбинации этих препаратов с НПВП. Исследования продемонстрировали, что комбинация латанопроста с НПВП достоверно повышает гипотензивную эффективность латанопроста на 17,8%, и уменьшает признаки раздражения глаза по шкале OSDI на 37%.
Drug treatment is of particular interest at all stages of the management of glaucoma patients. The safety profile and ease of use have placed PG F2 alpha analogues at the forefront of antihypertensive drug selection in the treatment of primary open-angle glaucoma. But there are also problematic points associated with the nature of synthetic prostaglandins, the presence of an admixture ofpro-inflammatory PGE in antihypertensive drugs. It is these circumstances that limit the use of PG F2 alpha analogues in patients with both primary and especially secondary glaucoma. The question of the additional use of NSAIDs in combination with synthetic prostaglandins to prevent side effects has been discussed in the literature, but there is no definite answer to this question. In this regard, we conducted a study comparing the effectiveness of latanoprost monotherapy in the classical and non-conservative variants and the combination of these drugs with NSAIDs. Studies have shown that the combination of latanoprost with NSAIDs significantly increases the antihypertensive efficacy of latanoprost by 17.8% and reduces signs of eye irritation on the OSDI scale by 37%.
Prospects of the Use of Levetiracetam with Controlled Release of Active Substance: a New Form of Levipil XR in Clinical Practice
Authors: Наумова Г.И. 
Published: February 2022

Внедрение в клиническую практику современных противоэпилептических средств существенно расширяет возможности и повышает эффективность лекарственной терапии эпилепсии благодаря их особой, порой уникальной фармакокинетике и фармакодинамике. При длительном применении противоэпилептических средств кроме показателей эффективности/ переносимости возрастает роль комплаентности терапии, что зачастую напрямую зависит от кратности приема препарата. Применение Левипила XR позволит избежать резких изменений концентрации леветирацетама в крови, что улучшит переносимость лечения, повысит показатель ремиссий, в том числе при фармакорезистентных эпилепсиях и эпилептических энцефалопатиях, улучшит качество жизни пациентов и длительность удержания на терапии.
Introduction of modern antiepileptic drugs into clinical practice significantly expands the possibilities and increases the effectiveness of drug therapy for epilepsy due to their special, sometimes unique pharmacokinetics and pharmacodynamics. With prolonged use of antiepileptic drugs, in addition to the indicators of effectiveness / tolerance, the role of compliance with therapy increases, which often directly depends on the frequency of administration of the drug. The use of Levipil XR lets to avoid abrupt changes in the concentration of levetiracetam in the blood, improves the tolerability of treatment, increases the rate of remission, including in pharmacoresistant epilepsies and epileptic encephalopathies, improves the quality of life and the duration of retention on therapy.
Clinical Case of Psychotherapy for Anxiety-Phobic Disorders in a Patient with Hysterical Personality Disorder
Authors: Николаев Е.Е. , Орлов Ф.В. , Иванова О.Ю. , Николаев Е.Л. 
Published: February 2022

Психотерапия пациентов с расстройствами личности представляет значительные трудности и вызывает вопросы в отношении ее эффективности. В данной статье описан клинический случай психотерапии тревожно-фобической симптоматики у пациента с истерическим расстройством личности. В лечении пациента был применен комплексный психотерапевтический подход, основанный на интеграции в систему личностно-ориентированной (реконструктивной) психотерапии методов групповой психотерапии, когнитивно-поведенческой терапии, арт-терапии. Индивидуальные и групповые психотерапевтические сессии с психотерапевтом и психологом, выполнение пациентом рисунков и их дальнейшее обсуждение завершились положительной внутренней трансформацией, сопровождающейся устранением беспокоящих пациента симптомов. Данный клинический случай, включающий результаты катамнестического наблюдения, демонстрирует, что проведение психотерапии у лиц с истерическим расстройством личности вполне оправданно. Она способствует смягчению сопутствующей психопатологической симптоматики, что улучшает качество жизни пациента и снижаетчастоту его обращений за медицинской и психологической помощью.
Psychotherapy for patients with personality disorders presents major difficulties and questions regarding its effectiveness. This article describes a clinical case of psychotherapy for anxiety-phobic symptoms in a patient with hysterical personality disorder. A complex psychotherapeutic approach was applied, based on the integration of the group psychotherapy, cognitive-behavioral therapy, and art therapy methods into the system of personality-oriented (reconstructive) psychotherapy. Individual and group psychotherapeutic sessions with a psychotherapist and a psychologist, the patient’s drawings, and their further discussion ended with a positive internal transformation, accompanied by elimination of the symptoms. This clinical case, including the results of follow-up observation, demonstrates that psychotherapy for persons with hysterical personality disorder is quite justified. It helps to improve the patient’s quality of life, reduces the frequency of their visits for medical and psychological assistance.
Еffectiveness of Renal Denervation in Patients with Resistant Arterial Hypertension Depending on the Beta-Blockers Taking
Authors: Плащинская Л.И. , Гончарик Д.Б. , Барсукевич В.Ч. , Гурин А.В. , Мрочек А.Г. 
Published: February 2022

Введение. В рецензируемой литературе нет сообщений, каким образом определенный класс антигипертензивных препаратов влияет на эффективность ренальной денервации (РДН). Цель. Анализ эффективности РДН у пациентов с резистентной артериальной гипертензией (РАГ) в зависимости от приема бета-адреноблокаторов (ББ) в рамках проспективного одноцентрового нерандомизированного клинического исследования эффективности и безопасности катетерной абляции симпатических нервов почечных артерий.Материалы и методы. В исследование было включено 92 пациента с РАГ, средний возраст составил 52 года (19; 68). Период наблюдения – 12 месяцев. Контрольные исследования офисного артериального давления (офАД) и суточное мониторирование АД (СМАД) выполнялись исходно до вмешательства, через 3, 6 и 12 месяцев после РДН. Пациенты были разделены на две группы: принимающие (n=74) и не принимающие ББ (n=18).Результаты. Более быстрая и выраженная динамика снижения среднесуточного АД через 3 месяца после РДН наблюдалась в группе пациентов, принимавших ББ. Большее снижение среднесуточного САД через 12 месяцев после РДН имело место в группе пациентов, принимавших ББ.Заключение. Анализ эффективности РДН в зависимости от приема ББ показал, что эффект РДН в снижении среднесуточного АД наблюдался раньше и был более выраженным у лиц, принимавших ББ, чем у тех, кто их не принимал.
Introduction. There is no information in the peer-reviewed literature on how a certain class of antihypertensive drugs affects the effectiveness of renal denervation (RDN).Purpose. Assessment of renal denervation (RDN) effectiveness in patients with resistant arterial hypertension (RH) depending on the intake of beta-blockers (BB) in the framework of a prospective single-center non-randomized clinical study of the RDN effectiveness and safety.Materials and methods. The research included 92 patients with RH. The average age was 52 years (19; 68). Control of the office blood pressure (BP) and ambulatory monitoring of the BP were performed initially before the intervention, in 3, 6 and 12 months after RDN. Patients were divided into two groups: those receiving beta-blockers (BB) (n=74) and those not taking BB (n=18).Results. More rapid and pronounced dynamics of decrease of the 24-hour average blood pressure was observed in the group of patients taking BB in 3 months after RDN. A greater reduction of the 24-hour average SBP took place in the group of patients taking BB in 12 months after RDN. Conclusion. Analysis of the effectiveness of RDN depending on the intake of BB showed that the effect of RDN in reducing the 24-hour average blood pressure was observed earlier and was more pronounced in patients, who took BB in comparison with those who did not take.
How Does Microbiota Form Rheumatic Diseases? Part 3
Authors: Рудой А.С. 
Published: February 2022

В кишечнике человека обитает чрезвычайно разнообразное и обильное микробное сообщество, которое корректирует и даже модулирует многие процессы, связанные со здоровьем.«Интерфейсы» слизистой оболочки являются особенно активными участками взаимодействия микроорганизмов и хозяев. Возрастающее понимание характерного состава и функции микробиоты кишечника выявило, что она не только участвует в поддержании целостности слизистой оболочки, но и затрагивает гомеостаз системы иммунитета с формированием как локальных, так и системных иммунных реакций. В представленном обзоре рассмотрена роль нарушений устойчивого состояния и взаимодействия хозяин – микроорганизм, которые могут потенциально влиять на развитие и прогрессирование ревматических заболеваний. В заключение будут рассмотрены вопросы новых терапевтических целей коррекции микробиоты.
The human gut harbors a tremendously diverse and abundant microbial community that corrects and even modulates many health-related processes. The “interfaces” of the intestinal mucous membrane are particularly active sites of interaction between microorganisms and hosts. The increasing understanding of typical composition and function of the gut microbiota revealed that it is involved not only in maintaining the integrity of the mucous membrane, but also it affects the homeostasis of the immune system with the formation of both local and systemic immune responses. This review describes the host–microorganism interplay, which can potentially affect the development and progression of rheumatic diseases. In conclusion, the issues of new therapeutic goals of microbiota correction will be considered.
Pengaruh Cekaman Salinitas terhadap Pertumbuhan Tanaman Semusim
Authors: Sihotang Tambun 
Published: February 2022

The purpose of the implementation of this practicum is to find out the effect of salinity checks on the growth of several plants a season. This experiment was conducted at the Plant Ecology Laboratory Agroecotechnology Study Program of the Faculty of Agriculture, University of North Sumatra, Medan on 21 April 2016 until May 19, 2016 at an altitude of 25 meters above sea level. This experiment was conducted using the factorial RandomIzed Design Method (RAK) with 2 factors, namely: Factor 1: Commodity (K) Level: K1 = Kale, K2 = Mustard; K3 = Green Beans; K4 = Corn, Factor 2: Salinity Level (S) Level: S0 = Control; S1 = Low; S2 = Medium; S3 = Height. The parameters observed are plant height (cm); number of leaves (strands); root volume (m3); root length (cm; wet weight of roots and headers; harvesting. From the results of the experiment it was obtained that the salinity level affected all parameters.
Extreme mechanical metamaterials with independently adjustable elastic modulus and mass density
Authors: Chen Xing , Cai Li , Wen Jihong 
Published: February 2022

Abstract
The mechanical properties of artificially periodic structures are closely related to the geometric dimensions of the structures. In this letter, we derive analytical expressions for the equivalent elastic parameters of a hexagonal cellular structure with additional counterweight mass blocks, and the accuracy of these analytical expressions is verified by numerical results. By analyzing the analytical expressions, we rigorously demonstrate an approximate decoupling relationship between the elastic modulus and mass density. Finally, we creatively propose a structure that can simultaneously achieve perfect decoupling of elastic modulus and mass density as well as flexible adjustment of material parameters in an ultra-wide range.
MOLECULAR DIAGNOSIS OF CRYPTOSPORIDIUM SSP. IN WATER BUFFALOES AT BABYLON PROVINCE, IRAQ
Authors: Al-Amery A. R. , Al-Amery A. M. A. 
Published: February 2022

This study was aimed recording the prevalence rates of the Cryptosporidium spp. and identify its species in buffalo at Babylon province by using microscopic (flotation and staining) and molecular technique to examined (100) buffalo fecal samples collected randomly from different sexes, ages, and regions, during the period from the beginning of October 2019, to end of March 2020. The percentage of infection with the Cryptosporidiosis was 40% by using the microscopic method, while, nested polymerase chain reaction (nPCR) technique showed the infection rate was 61%, and according to age groups, recorded higher infection 77.5% at (≤6) months age group, followed by age group (>6 -12) months and (>1 -2) years which showed 60% and 50%, besides, the age group (>2) years recorded 40%, which, the lowest infection rate. Also, females recorded (67.74%) as a higher prevalence rate than males (50%). Sequence analysis for ten samples that were positive by (n PCR) technique showed that 6 sequences belong to Cryptosporidium bovis (MT150692, MT150693, MT150694, MT150698, MT150699, and MT150701), while 3 sequence belongs to C. parvum (MT150696, MT150697, and MT150700), as well as, one of sequence belong to C. andersoni (MT150695), with a genetic difference of (0.010%) Datasets suggest strong genetic distinctiveness amongst species. The first diagnose of the Cryptosporidium and its species in water buffalo in Iraq by using molecular assay (nPCR).
Generalized Dold Sequences on Partially-Ordered Sets
Authors: Graff Grzegorz , Gulgowski Jacek , Lebiedź Małgorzata 
Published: February 2022

Dold sequences constitute an important class of integer sequences that play an important role in combinatorics, number theory, topology and dynamical systems. We generalize the notion of Dold sequence for the case of partially ordered sets and describe their properties. In particular we give two alternative descriptions of generalized Dold sequences: by some class of elementary sequences as well as by different generalized arithmetical functions, both defined on a partially ordered set. We also define vector Dold sequences and show their combinatorial interpretation in terms of periodic points.
Analisis Karakteristik Wilayah Permukiman Tanjung Pinggir
Authors: Silaban Yessy Christanti , Owen Mikel , Milala Maharanta 
Published: February 2022

Wilayah permukiman Tanjung Pinggir di daerah Sekupang, merupakan suatu permukiman yang tidak mengalami perkembangan arsitektural serta faktor pembentukan bangunan dinilai masih berada di tahap rendah. Elemen visual seperti prasarana serta bentuk fisik bangunan di permukiman tersebut dinilai tidak terlalu baik. Penelitian ini dilakukan dengan tujuan untuk menganalisis karakteristik suatu wilayah pesisir, baik dari kondisi prasarana serta bentuk fisik bangunan dan juga deskripsi luaran pada wilayah tersebut. Jenis penelitian yang dilakukan saat ini merupakan suatu metode penelitian kualitatif dengan pemaparan materinya berdasarkan ciri deskriptif. Data yang telah dipertimbangkan melalui pengamatan secara virtual, meliputi data fisik permukiman yang dijadikan sebagai bahan penelitian saat ini.
Measuring Chemical Likeness of Stars with Relevant Scaled Component Analysis
Authors: de Mijolla Damien , Ness Melissa K. 
Published: February 2022

Abstract
Identification of chemically similar stars using elemental abundances is core to many pursuits within Galactic archeology. However, measuring the chemical likeness of stars using abundances directly is limited by systematic imprints of imperfect synthetic spectra in abundance derivation. We present a novel data-driven model that is capable of identifying chemically similar stars from spectra alone. We call this relevant scaled component analysis (RSCA). RSCA finds a mapping from stellar spectra to a representation that optimizes recovery of known open clusters. By design, RSCA amplifies factors of chemical abundance variation and minimizes those of nonchemical parameters, such as instrument systematics. The resultant representation of stellar spectra can therefore be used for precise measurements of chemical similarity between stars. We validate RSCA using 185 cluster stars in 22 open clusters in the Apache Point Observatory Galactic Evolution Experiment survey. We quantify our performance in measuring chemical similarity using a reference set of 151,145 field stars. We find that our representation identifies known stellar siblings more effectively than stellar-abundance measurements. Using RSCA, 1.8% of pairs of field stars are as similar as birth siblings, compared to 2.3% when using stellar-abundance labels. We find that almost all of the information within spectra leveraged by RSCA fits into a two-dimensional basis, which we link to [Fe/H] and α-element abundances. We conclude that chemical tagging of stars to their birth clusters remains prohibitive. However, using the spectra has noticeable gain, and our approach is poised to benefit from larger data sets and improved algorithm designs.
Cross-scale Dynamics Driven by Plasma Jet Braking in Space
Authors: Liu C. M. , Vaivads A. , Khotyaintsev Y. V. , Fu H. S. , Graham D. B. , Steinvall K. , Liu Y. Y. , Burch J. L. 
Published: February 2022

Abstract
Plasma jets are ubiquitous in space. In geospace, jets can be generated by magnetic reconnection. These reconnection jets, typically at fluid scale, brake in the near-Earth region, dissipate their energies, and drive plasma dynamics at kinetic scales, generating field-aligned currents that are crucial to magnetospheric dynamics. Understanding of the cross-scale dynamics is fundamentally important, but observation of coupling among phenomena at various scales is highly challenging. Here we report, using unprecedentedly high-cadence data from NASA's Magnetospheric Multiscale Mission, the first observation of cross-scale dynamics driven by jet braking in geospace. We find that jet braking causes MHD-scale distortion of magnetic field lines and development of an ion-scale jet front that hosts strong Hall electric fields. Parallel electric fields arising from the ion-scale Hall potential generate intense electron-scale field-aligned currents, which drive strong Debye-scale turbulence. Debye-scale waves conversely limit intensity of the field-aligned currents, thereby coupling back to the large-scale dynamics. Our study can help in understanding how energy deposited in large-scale structures is transferred into small-scale structures in space.
4FGL J1120.0–2204: A Unique Gamma-Ray-bright Neutron Star Binary with an Extremely Low-mass Proto-white Dwarf
Authors: Swihart Samuel J. , Strader Jay , Aydi Elias , Chomiuk Laura , Dage Kristen C. , Kawash Adam , Sokolovsky Kirill V. , Ferrara Elizabeth C. 
Published: February 2022

Abstract
We have discovered a new X-ray-emitting compact binary that is the likely counterpart to the unassociated Fermi-LAT GeV γ-ray source 4FGL J1120.0–2204, the second brightest Fermi source that still remains formally unidentified. Using optical spectroscopy with the SOAR telescope, we have identified a warm (T
eff ∼ 8500 K) companion in a 15.1 hr orbit around an unseen primary, which is likely a yet-undiscovered millisecond pulsar. A precise Gaia parallax shows the binary is nearby, at a distance of only ∼820 pc. Unlike the typical “spider” or white dwarf secondaries in short-period millisecond pulsar binaries, our observations suggest the ∼0.17 M
⊙ companion is in an intermediate stage, contracting on the way to becoming an extremely low-mass helium white dwarf. Although the companion is apparently unique among confirmed or candidate millisecond pulsar binaries, we use binary evolution models to show that in ∼2 Gyr, the properties of the binary will match those of several millisecond pulsar–white dwarf binaries with very short (<1 day) orbital periods. This makes 4FGL J1120.0–2204 the first system discovered in the penultimate phase of the millisecond pulsar recycling process.
Weak Seasonality on Temperate Exoplanets around Low-mass Stars
Authors: Tan Xianyu 
Published: February 2022

Abstract
Planets with nonzero obliquity and/or orbital eccentricity experience seasonal variations of stellar irradiation at local latitudes. The extent of the atmospheric response can be crudely estimated by the ratio of the orbital timescale to the atmospheric radiative timescale. Given a set of atmospheric parameters, we show that this ratio depends mostly on the stellar properties and is independent of orbital distance and planetary equilibrium temperature. For Jupiter-like atmospheres, this ratio is ≪1 for planets around very low mass M dwarfs and ≳1 when the stellar mass is greater than about 0.6 solar mass. Complications can arise from various factors, including varying atmospheric metallicity, clouds, and atmospheric dynamics. Given the eccentricity and obliquity, the seasonal response is expected to be systematically weaker for gaseous exoplanets around low-mass stars and stronger for those around more massive stars. The amplitude and phase lag of atmospheric seasonal variations as a function of host stellar mass are quantified by idealized analytic models. At the infrared emission level in the photosphere, the relative amplitudes of thermal flux and temperature perturbations are negligible, and their phase lags are closed to −90° for Jupiter-like planets around very low mass stars. The relative amplitudes and phase lags increase gradually with increasing stellar mass. With a particular stellar mass, the relative amplitude and phase lag decrease from low- to high-infrared optical depth. We also present numerical calculations for a better illustration of the seasonal behaviors. Last, we discuss implications for the atmospheric circulation and future atmospheric characterization of exoplanets in systems with different stellar masses.