bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection and categorization of severe cardiac disorders based solely on heart period measurements
Authors: Shinomoto Shigeru , Tsubo Yasuhiro , Marunaka Yoshinori 
Published: October 2022

AbstractCardiac disorders are common conditions associated with a high mortality rate. Due to their potential for causing serious symptoms, it is desirable to constantly monitor cardiac status using an accessible device such as a smartwatch. While electrocardiograms (ECGs) can make the detailed diagnosis of cardiac disorders, the examination is typically performed only once a year for each individual during health checkups, and it requires expert medical practitioners to make comprehensive judgments. Here we describe a newly developed automated system for alerting individuals about cardiac disorders solely by measuring a series of heart periods. For this purpose, we examined two metrics of heart rate variability (HRV) and analyzed 1-day ECG recordings of more than 1,000 subjects in total. We found that a metric of local variation was more efficient than conventional HRV metrics for alerting cardiac disorders, and furthermore, that a newly introduced metric of local-global variation resulted in superior capacity for discriminating between premature contraction and atrial fibrillation. Even with a 1-minute recording of heart periods, our new detection system had a diagnostic performance even better than that of the conventional analysis method applied to a 1-day recording.
Slope–temperature faceting diagram for macrosteps at equilibrium
Authors: Akutsu Noriko , Akutsu Yasuhiro 
Published: October 2022

AbstractFaceting diagrams between surface slope and temperature are calculated numerically based on statistical mechanics for inclined surfaces between (001) and (111) surfaces at equilibrium. A lattice model is employed that includes point-contact-type step–step attractions from the quantum mechanical couplings between neighbouring steps. Comparing the obtained faceting diagrams with the phase diagram for step bunching proposed by Song and Mochrie for Si(113), the effective step–step attraction energy for Si(113) is approximately estimated to be 123 meV. The slope dependences of the mean height of the faceted macrosteps with a (111) side surface and that with a (001) side surface are calculated using the Monte Carlo method. The faceting diagrams can be used as a guide for controlling the assembling/disassembling of faceted macrosteps for designing new surface arrangements.
Integrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phospho-proteomics, and metabolomics
Authors: Doty Megan , Yun Sijung , Wang Yan , Hu Minghan , Cassidy Margaret , Hall Bradford , Kulkarni Ashok B. 
Published: October 2022

AbstractDiabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain soma of sensory neurons and modulate sensory signal transduction into the central nervous system. In this study, we aimed to gain a deeper understanding of changes in molecular pathways in the DRG of DPN patients with chronic pain. We recently reported transcriptomic changes in the DRG with DPN. Here, we expand upon those results with integrated metabolomic, proteomic, and phospho-proteomic analyses to compare the molecular profiles of DRG from DPN donors and DRG from control donors without diabetes or chronic pain. Our analyses identified decreases of select amino acids and phospholipid metabolites in the DRG from DPN donors, which are important for cellular maintenance. Additionally, our analyses revealed changes suggestive of extracellular matrix (ECM) remodeling and altered mRNA processing. These results reveal new insights into changes in the molecular profiles associated with DPN.
Mitochondrial transporter expression patterns distinguish tumor from normal tissue and identify cancer subtypes with different survival and metabolism
Authors: Wohlrab Hartmut , Signoretti Sabina , Rameh Lucia E. , DeConti Derrick K. , Hansen Steen H. 
Published: October 2022

AbstractTransporters of the inner mitochondrial membrane are essential to metabolism. We demonstrate that metabolism as represented by expression of genes encoding SLC25 transporters differentiates human cancers. Tumor to normal tissue expression ratios for clear cell renal cell carcinoma, colon adenocarcinoma, lung adenocarcinoma and breast invasive carcinoma were found to be highly significant. Affinity propagation trained on SLC25 gene expression patterns from 19 human cancer types (6825 TCGA samples) and normal tissues (2322 GTEx samples) was used to generate clusters. They differentiate cancers from normal tissues. They also indicate cancer subtypes with survivals distinct from the total patient population of the cancer type. Probing the kidney, colon, lung, and breast cancer clusters, subtype pairs of cancers were identified with distinct prognoses and differing in expression of protein coding genes from among 2080 metabolic enzymes assayed. We demonstrate that SLC25 expression clusters facilitate the identification of the tissue-of-origin, essential to efficacy of most cancer therapies, of CUPs (cancer-unknown-primary) known to have poor prognoses. Different cancer types within a single cluster have similar metabolic patterns and this raises the possibility that such cancers may respond similarly to existing and new anti-cancer therapies.
Stable iron isotopic composition of atmospheric aerosols: An overview
Authors: Wang Yuantao , Wu Libin , Hu Wei , Li Weijun , Shi Zongbo , Harrison Roy M. , Fu Pingqing 
Published: October 2022

AbstractAtmospheric particulate matter (PM) has a significant impact on both the natural environment and human health. Iron is one of the most abundant elements in the earth’s crust, playing an important role in geochemical processes, and is also an important trace component in atmospheric PM. In recent years, with the rapid development of non-traditional (metal) stable isotope technologies, new solutions and methods for the source apportionments of heavy metal elements have been put forward. Stable iron isotope analysis has become an effective tool to trace iron in atmospheric particles. This review paper briefly summarizes the recent progress of atmospheric iron isotope geochemistry. We show that some of the major natural and anthropogenic PM sources have different iron isotopic compositions. A Bayesian isotopic mixing model MixSIAR was used to quantitatively re-evaluate the contributions of different sources to iron in both urban and marine aerosols based on iron isotopic data in the literature. The results highlight the value of stable iron isotope analyses as an effective tool in the source apportionment of atmospheric aerosols.
Functional orderly topography of brain networks associated with gene expression heterogeneity
Authors: Liu Wei , Zeng Ling-Li , Shen Hui , Zhou Zong-Tan , Hu Dewen 
Published: October 2022

AbstractThe human cerebral cortex is vastly expanded relative to nonhuman primates and rodents, leading to a functional orderly topography of brain networks. Here, we show that functional topography may be associated with gene expression heterogeneity. The neocortex exhibits greater heterogeneity in gene expression, with a lower expression of housekeeping genes, a longer mean path length, fewer clusters, and a lower degree of ordering in networks than archicortical and subcortical areas in human, rhesus macaque, and mouse brains. In particular, the cerebellar cortex displays greater heterogeneity in gene expression than cerebellar deep nuclei in the human brain, but not in the mouse brain, corresponding to the emergence of novel functions in the human cerebellar cortex. Moreover, the cortical areas with greater heterogeneity, primarily located in the multimodal association cortex, tend to express genes with higher evolutionary rates and exhibit a higher degree of functional connectivity measured by resting-state fMRI, implying that such a spatial distribution of gene expression may be shaped by evolution and is favourable for the specialization of higher cognitive functions. Together, the cross-species imaging and genetic findings may provide convergent evidence to support the association between the orderly topography of brain function networks and gene expression.
What Is “Music” in Music-to-Language Transfer? Musical Ability But Not Musicianship Supports Cantonese Listeners' English Stress Perception
Authors: Choi William 
Published: October 2022

Purpose:This study investigates how Cantonese language experience influences the potential effects of (a) musicianship and (b) musical ability on English stress perception.Method:The sample contained 124 participants, evenly split into Cantonese musician, Cantonese nonmusician, English musician, and English nonmusician groups. They completed the English stress discrimination task, English stress sequence recall task, Musical Ear Test, and nonverbal intelligence task. Following the musicianship-based analysis, 44 Cantonese and English listeners were reassigned to four groups based on their musical ability—Cantonese high musical ability, Cantonese low musical ability, English high musical ability, and English low musical ability groups.Results:Musicianship-based analysis on English stress perception revealed a significant interaction between musicianship and language. Specifically, musicians outperformed nonmusicians only among the English but not the Cantonese listeners. By contrast, ability-based analysis showed significant main effects of musical ability and language. For both Cantonese and English listeners, those with a high musical ability outperformed those with a low musical ability. Regardless of musical ability, Cantonese listeners outperformed English listeners. Correlational analyses yielded consistent findings.Conclusions:This study has found cross-sectional evidence that musical ability, but not musicianship, facilitates Cantonese English as a second language (ESL) listeners' English stress perception. From a theoretical perspective, the current findings motivate two potential additions to the OPERA (Overlap, Precision, Emotion, Repetition, and Attention) hypothesis for music-to-language transfer—unsaturation and utilization. Practically, the findings cast doubt on the application of nonperceptual based instrumental music training to enhance Cantonese ESL learners' perceptual learning of English stress.Supplemental Material:https://doi.org/10.23641/asha.21266478
CP‐SyNet: A tool for generating customised cyber‐power synthetic network for distribution systems with distributed energy resources
Authors: Wang Lusha , Halvorsen James , Pannala Sanjeev , Srivastava Anurag , Gebremedhin Assefaw H. , Schulz Noel N. 
Published: October 2022

AbstractThe integration of distributed energy resources and advancement in information technology has enabled the transition of traditional power distribution systems to active cyber‐physical distribution systems. A growing amount of research has been done on the modelling, analysis, and optimisation of power distribution system behaviour. However, existing publicly available distribution test feeders are limited in numbers and have minimal features. Furthermore, these test feeders do not include cyber models and are not customisable. To bridge this gap, we propose and develop Cyber‐physical synthetic distribution system network (CP‐SyNet), a tool for generating customisable cyber‐physical synthetic distribution test feeders. CP‐SyNet generates three‐phase unbalanced test feeders according to users' requirements, while simultaneously considering both the cyber side and the physical side of the network for cyber‐physical analysis. The physical test network is developed using a graph‐theoretical approach that employs information from existing test feeders. The cyber side considers an equivalent communication network by transforming the physical topology into possible and feasible simulated network. Two examples are presented to demonstrate the feasibility of the proposed framework to generate cyber‐physical test feeders.
Astrocytes réactifs et maladies cérébrales
Authors: Poulot-Becq-Giraudon Yiannis , Carrillo-de Sauvage Maria-Angeles , Escartin Carole 
Published: October 2022

Les astrocytes sont des partenaires essentiels des neurones dans le système nerveux central. En réponse à de nombreuses maladies qui touchent le cerveau, les astrocytes subissent des modifications morphologiques, moléculaires et fonctionnelles : ils deviennent réactifs. Ces changements multiples sont susceptibles d’avoir un impact important sur les neurones, qui dépendent de nombreuses fonctions remplies par les astrocytes. La réponse de réactivité astrocytaire dépend du contexte pathologique. Il est donc indispensable de définir précisément les changements qui se produisent dans les astrocytes réactifs dans chaque situation pathologique, par des approches adaptées et sélectives. Cela permettra le développement de thérapies innovantes ciblant ces cellules partenaires des neurones, ainsi que l’identification de biomarqueurs spécifiques de certaines maladies cérébrales.
Mixed Reality in der Gefäßchirurgie – ein Scoping Review
Authors: Hatzl Johannes , Böckler Dittmar , Meisenbacher Katrin , Barb Alexandru , Hartmann Niklas , Henning Daniel , Uhl Christian 
Published: October 2022

Zusammenfassung
Hintergrund „Mixed Reality“ (MR) erlaubt die Projektion von virtuellen Objekten in das Sichtfeld des Anwenders durch ein Head-mounted Display (HMD). Im gefäßchirurgischen
Behandlungsspektrum könnten MR-Anwendungen in Zukunft einen Nutzen darstellen. Im folgenden Scoping Review soll eine Orientierung über die aktuelle Anwendung der genannten Technologien im
Bereich der Gefäßchirurgie gegeben und Forschungsziele für die Zukunft definiert werden. Material und Methoden Es erfolgte eine systematische Literaturrecherche in PubMed (MEDLINE)
mit den Suchbegriffen „aorta“, „intervention“, „endovsacular intervention“, „vascular surgery“, „aneurysm“, „endovascular“, „vascular access“ jeweils in Kombination mit „mixed reality“ oder
„augmented reality“. Die Suche erfolgte nach PRISMA-Leitlinie (Preferred Reporting Items for Systematic reviews and Meta-Analyses) für Scoping Reviews. Ergebnisse Aus 547
Literaturstellen konnten 8 relevante Studien identifiziert werden. Die Suchergebnisse konnten in 2 Anwendungskategorien eingeteilt werden: (1) MR mit dem Ziel des Informationsmanagements und
zur Verbesserung der periprozeduralen Ergonomie gefäßchirurgischer Eingriffe (n = 3) sowie (2) MR mit dem Ziel der intraoperativen Navigation bei gefäßchirurgischen Eingriffen (n = 5). Die
Registrierung des physischen Patienten mit dem virtuellen Objekt und das Tracking von Instrumenten in der MR-Umgebung zur intraoperativen Navigation ist dabei im Fokus des wissenschaftlichen
Interesses und konnte technisch erfolgreich am Phantom- und Tiermodell gezeigt werden. Die bisher vorgestellten Methoden sind jedoch mit hohem infrastrukturellem Aufwand und relevanten
Limitationen verbunden. Schlussfolgerung Der Einsatz von MR im Bereich der Gefäßchirurgie ist grundsätzlich vielversprechend. Für die Zukunft sollten alternative, pragmatische
Registrierungsmethoden mit entsprechender Quantifizierung des Positionierungsfehlers angestrebt werden. Die entwickelten Soft- und Hardwarelösungen sollten auf das Anforderungsprofil der
Gefäßchirurgie angepasst werden. Das elektromagnetische Instrumenten-Tracking erscheint als sinnvolle, komplementäre Technologie zur Umsetzung der MR-assistierten Navigation.
Phenotyping, Precision Medicine, and Asthma
Authors: Mohan Arjun , Lugogo Njira L. 
Published: October 2022

AbstractThe traditional one-size-fits all approach based on asthma severity is archaic. Asthma is a heterogenous syndrome rather than a single disease entity. Studies evaluating observable characteristics called phenotypes have elucidated this heterogeneity. Asthma clusters demonstrate overlapping features, are generally stable over time and are reproducible. What the identification of clusters may have failed to do, is move the needle of precision medicine meaningfully in asthma. This may be related to the lack of a straightforward and clinically meaningful way to apply what we have learned about asthma clusters. Clusters are based on both clinical factors and biomarkers. The use of biomarkers is slowly gaining popularity, but phenotyping based on biomarkers is generally greatly underutilized even in subspecialty care. Biomarkers are more often used to evaluate type 2 (T2) inflammatory signatures and eosinophils (sputum and blood), fractional exhaled nitric oxide (FeNO) and serum total and specific immunoglobulin (Ig) E reliably characterize the underlying inflammatory pathways. Biomarkers perform variably and clinicians must be familiar with their advantages and disadvantages to accurately apply them in clinical care. In addition, it is increasingly clear that clinical features are critical in understanding not only phenotypic characterization but in predicting response to therapy and future risk of poor outcomes. Strategies for asthma management will need to leverage our knowledge of biomarkers and clinical features to create composite scores and risk prediction tools that are clinically applicable. Despite significant progress, many questions remain, and more work is required to accurately identify non-T2 biomarkers. Adoption of phenotyping and more consistent use of biomarkers is needed, and we should continue to encourage this incorporation into practice.
Missed Opportunities: A Cross-Sectional Descriptive Study on Reasons for Nonadherence to the South African Expanded Program on Immunization
Authors: Edwin Roberta , Mackay Cheryl , Mda Siyazi 
Published: October 2022

Abstract
Objective Our objective was to identify factors which underline nonadherence to childhood immunizations provided by the Department of Health and outlined in the Expanded Program on Immunizations in South Africa.
Methods A cross-sectional descriptive study was conducted at Dora Nginza Hospital, a regional hospital in the Eastern Cape Province, which provides free health care in resource-limited settings. It included patients under the age of 5 years and their primary caregivers. A piloted questionnaire was used to collect data, and comparisons were made between children under the age of 5 years who missed one or more immunizations and those with complete immunizations. Data on maternal/caregiver and health system-related characteristics were also collected, and comparisons were made between the two groups.
Results Of the 200 participants enrolled in the study, 47 (23.5%) had incomplete immunizations. Prematurity (odds ratio [OR] = 0.33, p = 0.001), vaccine shortages (OR = 0.22, p < 0.005), and a low maternal/caregiver level of education (OR = 0.32, p = 0.002) were significantly associated with incomplete immunization status.
Conclusion Strategies to improve supply chain management of vaccines and to optimize follow-up care of high-risk children, specifically those born prematurely and those born to women of lower education level, need to be identified and implemented to reduce vaccine-preventable diseases.
The Clinical, Radiological, and Electrophysiological Profile of Children Presenting with Acute Fulminant Cerebral Edema Due to Suspected Encephalitis in an Eastern Indian Tertiary Care Center
Authors: Das Suman , Ray Biman Kanti , Mondal Gobinda , Paul Dilip Kumar , Chatterjee Kaushani , Mishra Lopamudra 
Published: October 2022

AbstractObjective Our objective was to describe the clinicodemographic, laboratory, and outcome profiles of a rare phenotype of pediatric acute encephalitis syndrome (AES) with acute fulminant cerebral edema (AFCE) and compare them with that of AES without AFCE.Methods We retrospectively analyzed medical records of a cluster of children hospitalized with encephalitis between June 1, 2021 and December 31, 2021. Their clinical and demographic features, laboratory investigations (hematological, biochemical, serological, microbiological, radiological, and electrophysiological tests), and follow-up data up to 3 months postdischarge were recorded. Patients with AFCE and those without it were divided into groups A and B, respectively, and their characteristics were compared.Results There were 11 and 15 patients in groups A and B, respectively. There were no significant differences between the two groups in terms of sex, neurological status at admission, hematological and cerebrospinal fluid values, pediatric intensive care unit (PICU) course, and management, etiological identification, and mortality and disabilities at discharge. Patients having reversal or having white cerebellar signs did not significantly differ in their outcomes. However, the patients in group A had significantly lower age, higher incidence of abnormal findings on head computed tomography scans at admission, longer duration of hospitalization, and neurological sequelae at 3 months. The numbers of patients with identified etiologies were zero in group A but five in group B (two Japanese encephalitis, two scrub typhus, and one dengue). Patients of group A had bilateral asymmetric temporal-parieto-occipital T2 hyperintense lesions in magnetic resonance imaging, whereas patients of group B had bifrontal predominant or thalamo-mesencephalic lesions. Multifocal epileptiform discharges were seen in electroencephalogram in both groups, which reverted to normal in 9 and 46% in groups A and B at 3 months, respectively.Conclusion Younger age is a significant risk factor for the development of AFCE in pediatric AES. AFCE patients have worse outcomes at 3 months, although they do not significantly differ from their non-AFCE counterparts at discharge. When occurring in clusters, AFCE patients exhibit the same radiological and electroencephalographic features.