bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEAttle-based Research of Chinese Herbs for COVID-19 Study: A Whole Health Perspective on Chinese Herbal Medicine for Symptoms that may be Related to COVID-19
Authors: Taylor-Swanson Lisa , Altschuler Daniel , Taromina Katherine , Anderson Belinda , Bensky Daniel , Cohen Misha , Huang Helen , Ma Shouchun , Majd Iman , Mitchell Craig , Schnyer Rosa N , Conboy Lisa 
Published: January 2022

Introduction East Asian Medicine (EAM) is a Whole System medicine that includes Chinese herbal medicine (CHM). Chinese herbal medicine has been utilized to reduce symptom burden in infectious disease, with notable theoretical reformulations during pandemics of the 3rd, 13th, and 17th centuries. Today, Licensed Acupuncturists trained in CHM have utilized it to treat symptoms and sequelae of COVID-19. However, little is known about its use or efficacy by the public and health practitioners. Understanding and evaluating whole medicine systems of healthcare is inherently complex; there is international consensus for a descriptive, pragmatic approach. We are conducting a feasibility pilot study using a prospective, pragmatic, observational design using Whole Health and Whole Person perspectives. The complexity of COVID-19 reflects the impact on multiple homeoregulatory systems and provides a unique opportunity to assess the impact of interventions such as EAM on whole health. Observation of these EAM encounters will provide valuable qualitative and quantitative data on the interface of an extant Whole System medicine with a novel complex illness as a precursor to a randomized clinical trial. Methods This ongoing study observes a CHM clinic offering telehealth consultations to a diverse patient population since April, 2020. Patients who report symptoms potentially related to COVID-19 disease are consented for standardized collection and analysis of demographic and clinical data from each clinical encounter. Results To date, 61 patients engaged in 195 consultations (mean 3.3) with 49 reporting symptom resolution sufficient to complete treatment, and 4 withdrawals. Just over half (62%) were female, with an average age of 45.7 years. A wide variety of CHM formulas and EAM dietary and lifestyle modifications were provided. Discussion Adequate recruitment and retention suggest feasibility of the intervention and data collection. The rich dataset may facilitate the construction of Whole Health models of CHM’s clinical impact, as well as integrative inquiry into CHM’s effects on symptoms.
COVID-19 Vaccine Hesitancy and How to Address It
Authors: Rittle Chad 
Published: January 2022

Background: Although many Americans were anxious to see a vaccine developed to help restore a sense of normalcy to the COVID-19 pandemic, vaccine hesitancy is still a problem that hinders public health goals designed to stop the spread of the virus. With two mRNA vaccines available since early 2021 only 71% of Americans have received at least one dose of vaccine by November 30, 2021, with 60% of the population being fully vaccinated. Methods: This article discusses the risk factors of vaccine hesitancy, the factors influencing the unwillingness to accept vaccines approved and recognized as safe, characteristics of vaccine hesitancy among worker populations, and guidelines and resources for nurses. Conclusions and Application to Practice: The key for the nurse is to self-educate and proactively begin the discussion of vaccines with patients and co-workers, building trust with patients and peers, and helping motivate them to accept COVID-19 vaccines and make appointments to receive vaccinations. Overcoming the impact of low vaccination rates due to vaccine hesitancy is the first step toward closing the gap and achieving universal vaccination for all adults.
Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial
Authors:   BEAR-MOON Design Group, Spindler Kurt P. , Imrey Peter B. , Yalcin Sercan , Beck Gerald J. , Calbrese Gary , Cox Charles L. , Fadale Paul D. , Farrow Lutul , Fitch Robert , Flanigan David , Fleming Braden C. , Hulstyn Michael J. , Jones Morgan H. , Kaeding Christopher , Katz Jeffrey N. , Kriz Peter , Magnussen Robert , McErlean Ellen , Melgaard Carrie , Owens Brett D. , Saluan Paul , Strnad Greg , Winalski Carl S. , Wright Rick 
Published: January 2022

Background: BEAR (bridge-enhanced anterior cruciate ligament [ACL] restoration), a paradigm-shifting technology to heal midsubstance ACL tears, has been demonstrated to be effective in a single-center 2:1 randomized controlled trial (RCT) versus hamstring ACL reconstruction. Widespread dissemination of BEAR into clinical practice should also be informed by a multicenter RCT to demonstrate exportability and compare efficacy with bone--patellar tendon–bone (BPTB) ACL reconstruction, another clinically standard treatment. Purpose: To present the design and initial preparation of a multicenter RCT of BEAR versus BPTB ACL reconstruction (the BEAR: Multicenter Orthopaedic Outcomes Network [BEAR-MOON] trial). Design and analytic issues in planning the complex BEAR-MOON trial, involving the US National Institute of Arthritis and Musculoskeletal and Skin Diseases, the US Food and Drug Administration, the BEAR implant manufacturer, a data and safety monitoring board, and institutional review boards, can usefully inform both clinicians on the trial’s strengths and limitations and future investigators on planning of complex orthopaedic studies. Study Design: Clinical trial. Methods: We describe the distinctive clinical, methodological, and operational challenges of comparing the innovative BEAR procedure with the well-established BPTB operation, and we outline the clinical motivation, experimental setting, study design, surgical challenges, rehabilitation, outcome measures, and planned analysis of the BEAR-MOON trial. Results: BEAR-MOON is a 6-center, 12-surgeon, 200-patient randomized, partially blinded, noninferiority RCT comparing BEAR with BPTB ACL reconstruction for treating first-time midsubstance ACL tears. Noninferiority of BEAR relative to BPTB will be claimed if the total score on the International Knee Documentation Committee (IKDC) subjective knee evaluation form and the knee arthrometer 30-lb (13.61-kg) side-to-side laxity difference are both within respective margins of 16 points for the IKDC and 2.5 mm for knee laxity. Conclusion: Major issues include patient selection, need for intraoperative randomization and treatment-specific postoperative physical therapy regimens (because of fundamental differences in surgical technique, initial stability construct, and healing), and choice of noninferiority margins for short-term efficacy outcomes of a novel intervention with evident short-term advantages and theoretical, but unverified, long-term benefits on other dimensions.
Quality of Life of Older People in Botswana
Authors: Mhaka-Mutepfa Magen , Wright Tshegofatso Caroline 
Published: January 2022

This article discusses social determinants of health that influence quality of life (QOL) of older people in Botswana and suggests appropriate interventions. A cross-sectional study stratified by district was used to collect information on the elderly (N = 378). Data were collected from: demographics, individual factors (e.g., self-esteem), health-related factors (e.g., self-perceived health), clinical variables (e.g., social dysfunction), environmental assets (e.g., leisure) and the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF). The analyses showed that income earned, self-efficacy and self-esteem, access to health services, self-perceived health, and chronic disease condition were associated with QOL. Social dysfunction and environmental assets (leisure, secure and healthy physical environments) were also significantly associated with QOL The results confirm that QOL is compromised by specific key factors. Thus, eradicating poverty, provision of services and a comfortable environment, promoting positive emotions (e.g., self-efficacy), and changing perceptions about self-rated health and self-rated QOL may enhance QOL among older people. The study has implications for policy, practice and further research.
The Modified Lemaire Procedure
Authors: Kittl Christoph , Wagner Michael , Weiler Andreas 
Published: January 2022

Background: Anterolateral rotatory instability (ALRI) may be one reasons why anterior cruciate ligament (ACL) reconstructions fail. An additional reconstruction of the anterolateral structures reduces the graft rupture rate by 50%. The modified Lemaire procedure is one of the lateral extra-articular tenodeses (LET) to restrain ALRI. The purpose of the present video is to describe this technique in detail. Indications: According to the international anterolateral complex consensus group indications may include revision ACL reconstruction, high grade pivot shift, generalized ligamentous laxity, like genu recurvatum, and young patients returning to pivoting activities. However, clinical evidence to recommend specific indications is still missing. Technique description: A 7 to 10 mm wide strip of the iliotibial tract, attached to Gerdy tubercle is shuttled deep to the lateral collateral ligament and is then attached proximal to the lateral femoral epicondyle. The biomechanical principle behind this is to place the graft posterior to the transverse axis of rotation through the entire range of motion. This posterior pull will restrain internal rotation and the anterior subluxation of the lateral tibial plateau. Results: Newer comparative studies show a reduced graft rupture rate and higher rate of returning to preinjury level, when adding an anterolateral extra-articular reconstruction to the ACL reconstruction at 2 years follow-up. At long-term follow-up there was also a trend toward decreased graft rupture rate. However, one must be aware of the possible increased risk of lateral compartment osteoarthritis. Conclusion: The modified Lemaire procedure is an easy-to-use addon to the ACL reconstruction, which can effectively reduce graft failure rate.
The Efficacy of ACR TI-RADS in the Management of Suspected Thyroid Nodules and Its Correlation With the Bethesda Scoring System
Authors: Karatay Emrah , Javadov Mirkhalig , Kartal Kinyas 
Published: January 2022

Objective: Ultrasonography (US) and fine-needle aspiration biopsy (FNAB) play an important role in the diagnosis of thyroid nodules. The primary aim of this study was to evaluate the relationship between American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) and the Bethesda system, based on final cytopathology. Materials and Methods: The cases that underwent thyroidectomy, due to a nodule, between May 2019 and May 2021 were retrospectively imaged. Of those cases, 73 patients were included in the study. The obtained data included ACR TI-RADS and the Bethesda system scores for nodules. Results: According to Spearman correlation, a very strong positive relationship was found between the Bethesda scoring system and ACR TI-RADS scores (ρ = 0.832, P < .0001). A 94.4% sensitivity and 65.4% specificity were found in 16 patients with a Bethesda score of 3 and TR3 based on final pathology ( P < .001). And a sensitivity of 77.3% and specificity of 51.5% were found in 17 patients, with a Bethesda score 4 and TR4 ( P < .001). Finally, a sensitivity of 55.6% and specificity of 50.0% were found in 17 patients with a Bethesda score 6 and TR5 ( P < .001). Conclusion: The routine use of the ACR TI-RADS classification in thyroid nodules could be useful in preventing unnecessary FNABs. It could be effective in minimizing complications secondary to FNAB and thyroidectomy and reducing costs.
A cognitively enhanced online Tai Ji Quan training intervention for community-dwelling older adults with mild cognitive impairment: A feasibility trial
Authors: Li Fuzhong , Harmer Peter , Fitzgerald Kathleen , Winters-Stone Kerri 
Published: January 2022

Abstract
Background
This study examines the feasibility, acceptability, and safety of a newly developed cognitive-enhancing Tai Ji Quan training intervention, delivered via remote videoconferencing, for older adults with mild cognitive impairment (MCI).

Methods
In a three-arm feasibility trial, community-dwelling older adults with MCI (N = 69; mean age = 74.6 years, 57% women) were randomized to a cognitively enhanced Tai Ji Quan (n = 23), standard Tai Ji Quan (n = 22), or stretching group (n = 24) and participated in a 60-minute online exercise session via Zoom, twice weekly for 16 weeks. Participants were recruited primarily in the state of Oregon through mass mailing and word of mouth. The primary outcomes were intervention feasibility (with respect to recruitment, online intervention delivery, fidelity and compliance, and attrition and retention rates), acceptability, and safety. We also assessed feasibility of online data collection and test-retest reliability and explored preliminary trends on secondary outcomes that included global cognitive function, dual-task cost, and domain-specific cognition function.

Results
The study had an average recruitment rate of 55%. Feasibility was demonstrated by the overall successful online program implementation, with good fidelity, acceptable compliance (76%), and excellent retention (94%). The cognitively enhanced Tai Ji Quan intervention was shown to be acceptable to participants as well as safe, with no major intervention-related moderate/severe events. At week 16, the group receiving cognitively enhanced Tai Ji Quan training showed a positive trend in the cognitive function and dual-task outcome measures whereas the group receiving standard Tai Ji Quan training exhibited positive trends on global and domain-specific cognitive measures.

Conclusions
Preliminary findings of this pilot study indicate the feasibility, acceptability, and safety of a tailored, cognitively enhanced Tai Ji Quan training intervention delivered remotely to home settings via videoconferencing for community-dwelling older adults with MCI.

Trial registration
Clinicaltrials.gov identifier NCT04070703
Types of household headship and associated life satisfaction among older adults in India: findings from LASI survey, 2017–18
Authors: Srivastava Shobhit , Muhammad T. , Sulaiman K. M. , Kumar Manish , Singh S. K. 
Published: January 2022

AbstractBackgroundHousehold headship with decision-making power may have a positive influence on life satisfaction in older adults. This study examines the associations of several types of household headship with life satisfaction among older adults in India.MethodThe study utilized the data from the Longitudinal Ageing Study in India (2017–18). The effective sample size for the study was 31,464 adults aged 60 years or older. Ordered logistic regression model was employed to find the association of life satisfaction with household headship status after adjusting for selected socioeconomic and demographic factors.ResultsIt was found that about 1.3% of older male and 1.5% of older females had nominal headship status in their household. Higher percentage of older males (42%) and females (48.3%) who had nominal headship status had low life satisfaction. In multivariable analysis, older adults who practiced nominal headship had significantly higher odds of low life satisfaction in reference to older adults who practiced functional headship [Adjusted odds ratio (AOR): 1.87; confidence interval (CI): 1.45,2.42]. Interaction model reveals that older men who practised nominal headship had significantly higher odds of low life satisfaction in reference to older men who practised functional headship [AOR: 2.34; CI: 1.59,3.45]. Similarly, older women who practised nominal headship had 55% significantly higher likelihood to have low life satisfaction in reference to older men who practised functional headship [AOR: 1.55; CI: 1.09, 2.18].ConclusionThe recognition of older individuals as active agents of the households they belong to, and giving them the value they deserve may help boosting their mental well-being. As a direct driver of subjective well-being, headship status and decision making power deserve a more prominent role and future studies are required on the mechanisms of functional and nominal headship statuses that have impact on successful aging.
Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis
Authors: Zhong Yi-Ming , Tong Fei , Shen Jun 
Published: January 2022

Abstract
Background
It is estimated that breast cancer (BC) incidence, especially that of early-stage breast cancer cases continues to rise due to increased universal screening. Breast-conserving surgery (BCS) is the main intervention for early-stage BC. Lympho-vascular invasion (LVI) is reported to influence breast cancer prognosis but its prognostic value in breast-conserving treatment is controversial.

Methods
A search was conducted on the Cochrane library, PubMed, Web of Science, and EMBASE from inception to December 1st, 2021, without language restrictions, to identify studies that explored the prognosis of lympho-vascular invasion in breast-conserving surgery. Reviews of each study were conducted, and data extracted. The meta-analysis was performed with StataSE 16. Study quality assessment was evaluated using the Newcastle–Ottawa Scale.

Results
Overall, 15 studies with 21,704 patients deemed eligible for this study. Event-free survival (EFS), disease-free survival (DFS), overall survival (OS), distant metastases (DM), loco-regional recurrence (LRR), local recurrence (LR), breast recurrence (BR), disease specific survival (DSS), and breast cancer specific survival (BCSS), were extracted from each study. We found that LVI leads to poor OS (HR = 1.46, 95% CI: 1.17–1.83), DM (HR = 2.08, 95% CI: 1.66–2.60) and LR (HR = 2.00, 95% CI: 1.54–2.61).

Conclusions
We confirmed that early-stage BC patients with LVI-positive have poorer OS, DFS, LRR, BCSS, DM and LR following receiving BCS than those LVI-negative patients. Mastectomy, in combination with radical systemic therapies could be considered, especially in those requiring second surgery. How to change the impact of LVI on the local recurrence rate and long-term survival in patients who undergo BCS may be a valuable research direction in the future.
Novel use of balloon-tipped bronchial blockers to occlude neonatal tracheoesophageal fistula: a case series
Authors: Sheng Bo , Zhong Lin , Du Bin 
Published: January 2022

Abstract
Background
Management of the airway and ventilation in neonates with a tracheoesophageal fistula (TEF) remains a significant challenge. The routine method of intubation involves placement of the tracheal tube tip beyond the fistula opening followed by isolation of the fistula from ventilation using the inflated cuff. When the fistula opening is close to the carina or below the level of the carina, the traditional technique is not suitable for adequate ventilation. Moreover, this method fails to prevent gastric insufflation.

Case presentation
We herein report a series of 10 newborns with TEFs (1,090–3,080 g) who underwent bronchoscopic insertion of a 5-Fr balloon-tipped bronchial blocker (BTBB) for temporary occlusion of the fistula. In seven newborns, placement of the BTBB was easily and quickly achieved with no incorrect placements. In addition, we successfully utilized the inner hollow cavity of the BTBB for gastric decompression in six neonates with severe gastric distension. However, three failed placements occurred in premature infants (<2,000 g) because the narrow cricoid cavity was too small to accommodate a 2.8-mm fiberoptic bronchoscope and a BTBB. The procedure was well tolerated by all infants, and no significant adverse events occurred.

Conclusions
Our findings illustrate that BTBBs can provide durable blockage of the fistula opening and should be considered as a treatment modality for infants with large carinal TEFs. Moreover, BTBB placement is neither arduous nor time-consuming. The hollow center, small round balloon, and 30-degree angled tip of the BTBB make this device feasible for clinical application, especially for neonates with severe gastrointestinal distension.
Analysis of E-mental health research: mapping the relationship between information technology and mental healthcare
Authors: Timakum Tatsawan , Xie Qing , Song Min 
Published: January 2022

Abstract
Background
E-mental healthcare is the convergence of digital technologies with mental health services. It has been developed to fill a gap in healthcare for people who need mental wellbeing support that may not otherwise receive psychological treatment. With an increasing number of e-mental healthcare and research, this study aimed to investigate the trends of an e-mental health research field that integrates interdisciplinary fields and to examine the information technologies is being used in mental healthcare. To achieve the research objectives, bibliometric analysis, information extraction, and network analysis were applied to analyze e-mental health research data.

Methods
E-mental health research data were obtained from 3663 bibliographic records from the Web of Science (WoS) and 3172 full-text articles from PubMed Central (PMC). The text mining techniques used for this study included bibliometric analysis, information extraction, and visualization.

Results
The e-mental health research topic trends primarily involved e-health care services and medical informatics research. The clusters of research comprised 16 clusters, which refer to mental sickness, e-health, diseases, information technology (IT), and self-management. The information extraction analysis revealed a triple relation with IT and biomedical domains. Betweenness centrality was used as a measure of network graph centrality, based on the shortest path to rank the important entities and triple relation; nodes with higher betweenness centrality had greater control over the network because more information passes through that node. The IT entity-relations of “mobile” had the highest score at 0.043466. The top pairs were related to depression, mobile health, and text message.

Conclusions
E-mental related publications were associated with various research fields, such as nursing, psychology, medical informatics, computer science, telecommunication, and healthcare innovation. We found that trends in e-mental health research are continually rising. These trends were related to the internet of things (IoT) and mobile applications (Apps), which were applied for mental healthcare services. Moreover, producing AI and machine learning for e-mental healthcare were being studied. This work supports the appropriate approaches and methods of e-mental health research that can help the researcher to identify important themes and choose the best fit with their own survey work.