bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodontal Disease Risk in Marfan Syndrome Patients Harboring a Possible Aortic Aneurysm or Dissection
Authors: Umezawa Kouta , Kajiwara Takako , Ishii Kyoko , Hasegawa Tatsuya , Suzuki Shigeto , Nakano Masato , Sawaguchi Mayu , Venkataiah Venkata Suresh , Yahata Yoshio , Ito Koki , Saiki Yoshikatsu , Saito Masahiro 
Published: March 2022

Abstract
BackgroundMarfan syndrome (MFS) is a systemic disorder of connective tissues caused by insufficient elastic fiber formation that leads to structural weakness and results in various tissue disorders, including cardiovascular and periodontal disease. Notably however, the risk of periodontal disease in MFS patients affected by an aortic aneurysm or dissection has not yet been clarified.MethodsWe investigated the periodontal condition in the following three groups: MFS patients diagnosed with an aortic aneurysm or dissection with a planned aortic surgery (MFS surgery), MFS patients who had already undergone aortic surgery (MFS post-surgery) and healthy control patients (Healthy). The periodontal condition of all of these patients was evaluated at their first visit, reassessed again at two-month after the first visit, and evaluated again at a six-month follow-up after the reassessment. ResultsA total of 14 participants, 3 MFS surgery patients, 4 MFS post-surgery patients and 7 healthy control volunteers were examined. Saliva examinations revealed no significant differences between any of the groups at the first visit, reassessment, or follow-up. Interestingly, the MFS surgery cases showed a higher BOP and PISA at the first visit and follow-up compared with the other groups. In contrast, the MFS surgery patients showed an improvement in their LVDd and EF values, both markers of cardiac function, at the reassessment and follow-up compared with the first visit. ConclusionsMFS associated with an aortic aneurysm or dissection leads to a higher risk of periodontal disease, indicating the need for more frequent oral hygiene maintenance in these patients. In addition, MFS patients who undergo frequent professional cleaning of their teeth show a lower onset of cardiovascular disease, suggesting that professional oral hygiene in these cases contributes to a healthier condition.
Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse skeletal muscle dysfunction in age-associated sarcopenia mice
Authors: Jia Yali , Wang Ailing , Wang Chao , Zhai Jinglei , Zhao Bichun , Liao Tuling , Cao Ning , Su Ruyu , He Lijuan , Li Yanhua , Yue Wen , Pei Xuetao 
Published: March 2022

Abstract
With the expansion of the ageing population, age-associated sarcopenia (AAS) has become a severe clinical disease of the elderly and a key challenge for healthy ageing. However, there are no approved therapies for AAS. In this study, we first used clinical-grade human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) to treat AAS in two classic mouse models (SAMP8 mice and D-galactose-induced ageing mice) and studied the effects at the behavioural, histological, cellular and molecular levels by means of behavioural tests, immunostaining, western blotting and others. Core data results showed that hUC-MSCs dramatically restored skeletal muscle strength and performance in two AAS mouse models via the mechanisms including raising the expression of crucial extracellular matrix proteins, activating satellite cells, enhancing autophagy, and impeding the cellular ageing. For the first time, we comprehensively evaluated and demonstrated the preclinical efficacy of clinical-grade hUC-MSCs in the treatment of AAS in two mouse models. Our study highlights a promising strategy to improve and treat AAS and other age-associated muscle diseases.
Association between fetal-type posterior cerebral artery and intracranial anterior and posterior circulating atherosclerotic plaque on high-resolution MRI at 3.0T
Authors: Liu Dingqi , Xin Ruijing , Zhao Deng-Ling , Chen Xiao-Hui , Li Cheng 
Published: March 2022

Abstract
Objectives
Atherosclerotic high-risk plaque rupture is one of the important factors leading to ischemic stroke. The present study used HRMRI to quantitatively analyze the association between the fetal-type posterior artery and intracranial anterior and posterior circulating atherosclerotic plaques.
Materials and Methods
A total of 58 patients (25 patients with fetal-type posterior artery and 33 patients without fetal-type posterior artery) were included for 3.0T HRMRI scan analysis. The images of the MCA and VBA vessel wall on HRMRI were compared between the two groups based on the degree of stenosis, remodeling index, and eccentricity degree.
Results
Positive remodeling of MCA plaques was more frequently observed in the fetal-type posterior artery group than in the control group (P < 0.05). The remodeling Index (95% CI, 0.001–0.474; P = 0.015) was associated with fetal-type posterior artery following the adjustment for the confounding factors. No significant differences were found in the VBA plaque characteristics between the two groups (P > 0.05).
Conclusion
Fetal-type posterior artery promotes the development of atherosclerosis plaque and positive vessel remodeling in middle cerebral artery, whereas it exhibits no association with vertebrobasilar artery plaque formation.
Case Report of Angiocentric Glioma Lacking Epilepsy and Discuss Its Relationship With Epilepsy
Authors: Cheng HaiLun , Yin WeiHua , Xu QinQin , Shi XiaoXin 
Published: March 2022

Abstract
Background: Angiocentric glioma is a rare neuro tumor, the general public believes that the typical clinical feature of angiocentric glioma (AG) is a history of epilepsy. This case have unique research value because it is lack history of epilepsy, it is provide evidence to exploration of the causes of AG-related epilepsy symptoms.Case presentations: A 16-year-old boy came to the hospital because of dizziness and blurred vision. The patient's CT stan detected a solid mass in the right frontotemporal lobe. Histologic finding the tumor is predominantly composed of elongated tumor cells forming rings around the blood vessels, the immunohistochemical staining show GFAP、D2-40、S100、Vimentin have positive expression, and Ki-67 proliferation index is 1%~5%, FISH-tissue show MYB gene rearrangement detection. According these evidences, this case was diagnosed as angiocentric glioma. the patient's physical condition was stable and there was no recurrence after the operation.Conclusion: We believe that MYB gene break rearrangement is related to the cause of AG and MYB-QKI gene rearrangement may be one of the important causes of AG, but it is not directly related to AG-related epilepsy.
MDP regulates BMSC differentiation and bone formation through miR-384-5p/Lepr
Authors: Feng Yun-Zhi , Zhang Shao-Hui , Guo Yue , Chen Yun , Liu Qiong , Tan Li , Gao Zheng-Rong , Zhao Jie , Zhao Ya-Qiong , Feng Yao , Hu Jing , Ye Qing , Ou-Yang Zhe-Yue , Zhou Ying-Hui 
Published: March 2022

Abstract
The main components of bacterial flora are closely related to bone metabolism. Peptidoglycan-based muramyl dipeptide (MDP) is present in bacterial cell walls. We found an association of energy metabolism with MDP in mice fed different diets. Leptin receptor (Lepr) expression in alveolar bone and the femur was increased drastically in the high-fat-diet group with MDP (H-MDP) compared with that in the high-fat-diet control (H-NaCl) group and low-fat-diet (LFD) group. The bone mass of mice was decreased after MDP intervention in the LFD group whereas, in the high-fat-diet (HFD) group, it was increased upon MDP intervention. Micro-RNA (miR)-384-5p targeted and inhibited Lepr expression in vitro . We extracted the supernatants of osteocytes cultured under different conditions with MDP intervention to act on bone marrow stromal cells (BMSCs) and found that miR-384-5p could regulate epr expression and osteogenic differentiation in BMSCs. Our findings indicate a possible mechanism of periodontitis-associated alveolar bone changes caused by the main components of microflora.
PRMT5 regulates the NAD-SIRT1-p53 signal axis by affecting the methylation of CD38 at R58 to promote malignant tumor cell proliferation
Authors: Zhou Yanhong , Liang Lin , Yue Chunxue , Li Wentao , Gao Mengxiang , Zeng Feng , He Junyu , He Zhengxi , Jin Xi , Liao Qianjin , Luo Gengqiu , Li Xin 
Published: March 2022

Abstract
The cell surface receptor CD38 has NADase enzyme and cyclase activity and is necessary for immune cell activation and proliferation. CD38 is a molecular marker for hematological tumor prognosis and diagnosis; however, its role in solid tumors is unclear. This study aimed to explore the role and mechanism of CD38 in the proliferation of solid tumor cells. We found that protein arginine methyltransferase 5 (PRMT5) interacts with CD38 in solid tumor cell lines, resulting in increased levels of CD38. In addition, PRMT5 can methylate CD38 at arginine 58 (R58). Moreover, PRMT5-induced methylation of CD38 affected its enzymatic activity and the NAD level. Finally, in vitro experiments showed that PRMT5-induced methylation of regulates the activity of the CD38-NAD-SIRT1-p53-p21 signal axis to promote the proliferation of solid tumor cells. In summary, PRMT5 promotes malignant tumor cell proliferation by regulating the methylation status of CD38 in solid tumors such as cervical cancer, nasopharyngeal carcinoma, and lung cancer. CD38 R58 could be applied in the early diagnosis and clinical treatment of solid tumors.
Predictive Value of 68Ga-FAPI-04 PET/MR for Left Ventricular Remodeling in Patients with Acute Myocardial Infarction
Authors: Zhang Min , Quan Weiwei , Zhu Tianqi , Feng Shuo , Huang Xinyun , Meng Hongping , Du Run , Zhu Zhengbin , Qu Xuezheng , Li Ping , Yan Xiaoxiang , Zhang Ruiyan , Li Biao 
Published: March 2022

Abstract
Purpose
To observe longitudinal changes of myocardial fibroblasts activation by 68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI-04) PET/MR in patients with ST-segment elevated myocardial infarction (STEMI), and assess its predictive value for late left ventricular remodeling (LVR).
Methods
Forty-two patients with STEMI were included in the study. 68Ga-FAPI-04 PET/MR was performed at baseline (5.1 ± 3.0 days) and at 12 months (12.0 ± 1.1 months) after STEMI. The extent of activated myocardial fibroblasts were quantified using 68Ga-FAPI-04 uptake volume (UV). Infarct size was expressed as late gadolinium enhancement (LGE) volume. LVR was defined as > 10% increase in left ventricular end-systolic volume (LVESV) from baseline to 12 months measured by echocardiography.
Results
Baseline 68Ga-FAPI-04 uptake volume (UV) was a significant predictor of the change in LVESV (B = 0.083, p = 0.023) from baseline to 12 months after AMI. The LVR group demonstrated higher 68Ga-FAPI-04 UV at baseline than the non-LVR group (p = 0.013). The area under the curve (AUC) of 68Ga-FAPI-04 UV at baseline for predicting the LVR reached 0.833 (p = 0.019), with sensitivity of 100.0% and specificity of 60.0%.
Conclusion
68Ga-FAPI-04 PET/MR is a useful tool to non-invasively quantify myocardial fibroblasts activation, and baseline 68Ga-FAPI-04 UV in the early stage of STEMI may have predictive value for the late LVR.
Solvent Dependency of Adsorption of Mercaptopurine on CC, AlN and BN Nanotubes and the Evaluation of Noncovalent Interactions
Authors: Al-Otaibi Jamelah S , Mary Y. Sheena , Mary Y. Shyma , Thomas Renjith 
Published: March 2022

Abstract
The performance of nanotubes (NT) of carbon (CC), aluminium-nitrogen (AlN) and boron-nitrogen (BN) as a sensor and nanocarrier for mercaptopurine (MCP) was investigated by means of theoretical approach. The calculated negative values of adsorption energy showed the interaction and adsorption of the drug. HOMO and LUMO distributions were only found on the NT counter portion of drug-nanotube not on MCP for AlN-NT and BN-NT while HOMO is over MCP and LUMO is over NT for CC-NT. The polarizability of MCP-NTs is greater than that of MCP. Raman wavenumbers of MCP are enhanced in NTs and hence NTs can act as a sensor for detection of MCP. Solvent dependency on adsorption behavior is also presented in the manuscript, where we found that AlN nanotube showed exceptionally high free energy of adsorption over other nanotubes in all solvent medium. Solvation free energies were also reported. Non covalent interaction scattered plot also showed significant inter molecular interaction between AlN nanotubes and the mercaptopurine when compared to other nanotubes under study.
Association Between Early Ondansetron Administration and In-Hospital Mortality in Critically Ill Patients: Analysis of the MIMIC-IV Database
Authors: Fang Yingying , Wang Xinghe , Xiong Chao 
Published: March 2022

Abstract
BackgroundWhile ondansetron (OND) is widespread availability, the contribution of OND to improve patient outcomes among intensive care unit (ICU) patients has not been examined. This study aimed to illustrate the association between early OND use and in-hospital mortality in critically ill patients and investigate whether this association differed according to OND dose. MethodsThe MIMIC-IV database was employed to identify patients who had and had not received OND. Statistical approaches included multivariate logistic regression, propensity score matching (PSM), and propensity score-based inverse probability of treatment weighting (IPTW) models to ensure the robustness of our findings.ResultsIn total, 51342 ICU patients were included. A significant benefit in terms of in-hospital mortality was observed in the OND patients compared to the non-OND group in the early stage [odds ratio (OR) = 0.75, 95% CI 0.63-0.89, p < 0.001]. In the circulatory system group, the early OND administration was associated with improved in-hospital mortality in ICU patients (OR 0.48, 95% CI 0.34-0.66; P < 0.001). The risk of in-hospital mortality was also lower in early OND users than in non-OND users both in the medical admission group and the surgical ICU admission group, and ORs were 0.57 (95% CI 0.42-0.76; P < 0.001) and 0.79 (95% CI 0.62-0.91; P < 0.001), respectively. A positive role of daily low- and moderate-dose OND treatment in early-stage was showed on the in-hospital mortality in PSM cohort, and the ORs were 0.75 (95% CI 0.62-0.90; P < 0.001) and 0.63 (95% CI 0.43-0.91; P < 0.001), respectively. The relationship between the daily low- and moderate-dose of OND and in-hospital mortality was also significant in ICU patients with cardiovascular diseases, and ORs were 0.51(95% CI 0.36-0.73; P < 0.001), and 0.26(95% CI 0.11-0.65; P < 0.001), respectively. Daily low-to-moderate dose of OND was also associated with in-hospital mortality in ICU entire cohort.ConclusionsEarly OND use is closely associated with lower in-hospital mortality in ICU patients. Daily low-to-moderate dose of OND application is protective against in-hospital mortality. This association is more evident in the circulatory system group.
Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism
Authors: Liu Li , Peng Min-Zhi , Shao Yong-Xian , Li Xiu-Zhen , Zhang Kang-Di , Cai Yan-Na , Lin Yun-Ting , Jiang Min-Yan , Liu Zong-Cai , Su Xue-Ying , Zhang Wen , Jiang Xiao-Ling 
Published: March 2022

Abstract
The SLC25A32 dysfunction is associated with neural tube defects (NTDs) and exercise intolerance, but very little is known about disease specific mechanisms due to a paucity of animal models. Here, we generated homozygous (Slc25a32Y174C/Y174C and Slc25a32K235R/K235R) and compound heterozygous (Slc25a32Y174C/K235R) knock-in mice by mimicking the missense mutations identified from our patient. A homozygous knock-out (Slc25a32-/-) mouse was also generated. The Slc25a32K235R/K235R and Slc25a32Y174C/K235R mice presented with mild motor impairment and recapitulated the biochemical disturbances of the patient. While Slc25a32-/- mice die in utero with NTDs. All Slc25a32 mutations did not hinder the mitochondrial uptake of folates but specifically blocked the uptake of flavin adenine dinucleotide (FAD). A positive correlation between SLC25A32 dysfunction and flavoenzyme deficiency was observed. Besides the flavoenzymes involved in fatty acid β-oxidation and amino acid metabolism impaired, Slc25a32-/- embryos still had a subunit of glycine cleavage system–dihydrolipoamide dehydrogenase damaged, resulting in glycine accumulation and glycine derived-formate reduction, which further disturbed folate-mediated one-carbon metabolism, leading to 5-methyltetrahydrofolate shortage and other folate intermediates accumulated. Maternal formate supplementation increased the 5-methyltetrahydrofolate levels and ameliorated the NTDs in Slc25a32-/- embryos. The Slc25a32K235R/K235R mice had no glycine oxidation defect but had another formate donor-choline metabolism interrupted and mitochondrial folates deficient. Formate supplementation increased mitochondrial folates amounts of mice, but this effect was not restricted to the Slc25a32 mutant mice. In summary, we established novel animal models, which enabled us to better understand the function of SLC25A32 and to elucidate the role of SLC25A32 dysfunction in human disease development and progression.
IL-7R and CCR7 Regulate Distinct Metabolic Pathways in Naïve T Cells to Promote T Cell Motility
Authors: Byrum Janie R , Gridley Rebekah , Torres David J , Mrass Paulus , Oruganti Sreenivasa Rao , Cannon Judy L 
Published: March 2022

Abstract
Naïve T cells movement through tissues, including through lymph nodes, requires ongoing energy supply for rapid motility promoting T cell scanning of dendritic cells and T cell activation. Rapid movement is facilitated by signaling through chemokine receptor CCR7, but how signaling to motility relates to T cell metabolism is not well understood. Conversely, whether signals including IL-7R which are known to regulate naïve T cell metabolism might impact motility is not known. We analyze how CCR7 and IL-7R regulate T cell motility and metabolism. Using Seahorse analysis, we find that CCL21 signaling to CCR7 decreases oxidative phosphorylation, but has no effect on glycolysis. In contrast, IL-7 promotes glycolysis but shows no effect on respiration. We demonstrate a previously unidentified role for IL-7/IL-7R in promotion of T cell motility in lymph nodes by imaging T cell movement in lymph nodes after inhibition of IL-7R and IL-7. Downstream of IL-7R, JAK3 and STAT5, but not mTOR, mediates rapid motility. Our results shed new light on how metabolism intersects with motility to promote more efficient T cell movement within lymph nodes to promote potential for DC scanning and interaction, potentially through differential means of ATP production.
High friction mechanism of ZDDP tribofilm based on in-situ AFM observation of nano-friction and adhesion properties
Authors: Sato Kaisei , Watanabe Seiya , Sasaki Shinya 
Published: March 2022

Abstract
Zinc dialkyl dithiophosphate (ZDDP) is a typical anti-wear additive that forms tribofilm on sliding surfaces and prevents adhesion wear but increases the friction force. In this study, the nano-friction and adhesion properties of ZDDP tribofilms were investigated by performing in-situ observations by atomic force microscopy to explore the relationship between the formation process and physical properties of ZDDP tribofilm. The results showed that the nano-friction force increased with the formation of the ZDDP tribofilm. In addition, the adhesion force on the ZDDP tribofilm increased with the friction force. It was confirmed that the Young's modulus and nanoindentation hardness of the ZDDP tribofilms were lower than those of steel. However, the contact areas calculated using the Hertz contact theory were similar. In addition, the shear strengths, calculated with the contact areas of the Hertz model, of the ZDDP tribofilm were substantially higher than those of steel. From the above, it was hypothesized that the high friction force of the ZDDP tribofilm was derived from the high adhesion layer at the surface.
Dating App Usage and Motivations for Dating App Usage are Associated with Increased Disordered Eating
Authors: Blake K. , Portingale J. , Giles S. , Griffiths S. , Krug Isabel 
Published: March 2022

Abstract
Purpose
The centrality of physical appearance in dating app environments may constitute an appearance related pressure that increases the likelihood of body dissatisfaction (BD) and disordered eating (DE). Although dating app use has been linked to BD and DE, prior research has neglected the role of individuals’ dating app use motivations and relevant traits in eating pathology. To address these gaps, the current study investigated whether dating app usage moderated the effects of appearance-based rejection sensitivity (appearance-RS), fear of negative evaluation (FNE), emotion dysregulation, and perceived social rank on DE, and the unique association between individuals’ dating app use motivations and DE.
Methods
Participants (N = 690) completed baseline measures of demographic and trait variables including dating app usage.
Results
DE was positively associated with female gender, higher body mass index, a history of eating disorder (ED) diagnosis, appearance-RS, and emotion dysregulation. Dating app users were more likely to report DE symptoms, appearance-RS, and emotion dysregulation. No investigated predictor was moderated by dating app usage, but four of the six measured motivations for using dating apps were associated with DE among the dating app user sample.
Conclusion
Given that DE behaviors can lead to EDs, the present findings suggest that lifetime dating app usage may constitute a socio-cultural appearance pressure which confers DE risk.
Level of evidence
: Level V; descriptive study
Pattern dynamics of a vegetation model with nonlocal interactions
Authors: Liang Juan , LI LI , JIN ZHEN , Wu Yong Ping , Feng Guo Lin , Li Bai-Lian , Sun Gui-Quan 
Published: March 2022

Abstract
In order to understand the mechanism of water uptake by vegetation, we propose a vegetation-water model which represents nonlocal effect via nonlocal delay in this paper. By mathematical analysis, the condition of producing steady pattern is obtained. Furthermore, the amplitude equation which determines the type of Turing pattern is obtained by nonlinear analysis method. The corresponding vegetation pattern and evolution process under different intensity of nonlocal effect in roots of vegetation are given by numerical simulations. There is a positive correlation between the intensity of nonlocal effect and vegetation density, that is, the vegetation density increases with the increase of the intensity of nonlocal effect. Numerical simulation shows that as intensity of nonlocal effect increased, the isolation degree of vegetation pattern increases which indicates that the robustness of the ecosystem decreases. Besides, the results reveal that with the water diffusion coeffificient increase, the vegetation pattern transitions: stripe pattern→mix pattern→spot pattern emerge which predicts transitions from stripe vegetation to bare soil. Our results show the effects of intensity of nonlocal effect and diffusion coeffificient on vegetation distribution, which provides theoretical basis for the study of vegetation.
Improving the Accuracy of Estimates of the Pulse Sequence Period Using the Methodology of Complete Sufficient Statistics
Authors: Жучков Константин , Vasilchenko Mikhail , Zagrebneva Anna , Zavyalov Alexey 
Published: March 2022

Abstract
ࣧ Using a model of a sequence of quasi-rectangular pulses as an example, an approach was illustrated to assess their period, taking into account the off-duty factor and the squareness coefficient of the pulses. Complete sufficient statistics (CSS) methodology was used. An analytical expression for the pulse repetition was presented. It was shown that for the value of the sample size (n > 8) the relative root-mean square error of the repetition period estimation by CSS is shown as a significantly smaller error than that of the traditional estimate, which is only asymptotically effective. In addition to theoretical calculations, simulation results confirming the achieved effect are presented. The results obtained are applicable for the design of the control and measuring equipment of the oil and gas industry.