bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability of cognitive remediation for schizophrenia: a systematic review and meta-analysis of randomized controlled trials
Authors: Vita Antonio , Barlati Stefano , Ceraso Anna , Deste Giacomo , Nibbio Gabriele , Wykes Til 
Published: March 2022

AbstractBackgroundAcceptability is an important factor for predicting intervention use and potential treatment outcomes in psychosocial interventions. Cognitive remediation (CR) improves cognition and functioning in people with a diagnosis of schizophrenia, but its acceptability, and the impact of participants and treatment characteristics, remain to be investigated. Few studies provide a direct measure of acceptability, but treatment drop-out rates are often available and represent a valid surrogate.MethodThe systematic search conducted for the most comprehensive CR outcomes database for schizophrenia was updated in December 2020. Eligible studies were randomized clinical trials comparing CR with any other control condition in patients diagnosed with schizophrenia spectrum disorders and that also reported drop-out in treatment and control arms separately. Acceptability was measured as odd-ratios (OR) of drop-out.ResultsOf 2119 identified reports, 151 studies, reporting 169 comparisons between CR and control interventions with 10 477 participants were included in the analyses. The overall rate of drop-out was 16.58% for CR programs and 15.21% for control conditions. In the meta-analysis, no difference emerged between CR interventions and controls [OR 1.10, 95% confidence interval (CI) 0.96–1.25, p = 0.177]. Factors improving acceptability were: inpatient only recruitment, participants with fewer years of education and lower premorbid IQ, the presence of all CR core elements, and the presence of techniques to transfer cognitive gains into real-world functioning.ConclusionsCR for people diagnosed with schizophrenia is effective and has a good acceptability profile, similar to that of other evidence-based psychosocial interventions.
European Network for Health Technology Assessment’s Response to COVID-19: Rapid Collaborative Reviews on Diagnostic Tests and Rolling and Rapid Collaborative Reviews on Therapeutics
Authors: Ballini Luciana , Wild Claudia , Djuric Olivera , Mayer-Ferbas Julia , Willemsen Anne , Huic Mirjana 
Published: March 2022

Abstract

Objectives
In spring 2020, The European network for Health Technology Assessment (EUnetHTA) decided to join forces to produce best evidence to inform health policy in the COVID-19 pandemic. The objective of this paper is to describe the process and output of the coordinated and collaborative activities of EUnetHTA.

Methods
Relevant published and internal documents were retrieved for a descriptive analysis of EUnetHTA processes, methods, and outputs related to EUnetHTA’s response to the pandemic.

Results
Process: In April 2020, a COVID-19 task force was set up and a survey collected pressing health policy questions across Europe. Two coordinating agencies for diagnostic tests and therapeutics were assigned. A process for prioritization and selection was set up for therapeutics, as well as explicit starting and stopping rules. Methodology: To increase a timely response, it was agreed that the rapid collaborative reviews (rapid CRs) would not require the consultation of manufacturers and the involvement of external experts, but would not differ in the methods and conduct of the systematic search, review, and synthesis of all available evidence, nor in the requirement for reviewing by EUnetHTA partners. Final reports: The joint effort resulted in the production of two rapid CRs on diagnostic tests, nineteen collaborative rolling reviews on therapeutics, three of which later moved to rapid CRs.

Conclusions
During COVID-19 pandemic, the EUnetHTA partners proved capable of prompt collaboration, which allowed speeding up the production and release of high-quality EUnetHTA outputs, while the relationships with the other European institutions facilitated their quick dissemination.
An Agile Development Cycle of an Online Memory Program for Healthy Older Adults
Authors: Yusupov Iris , Vandermorris Susan , Plunkett Cindy , Astell Arlene , Rich Jill B. , Troyer Angela K. 
Published: March 2022

AbstractOnline interventions for older adults should be tailored to their unique needs to increase the efficacy of and adherence to the intervention. The agile development cycle is a dynamic model to solicit and incorporate feedback from older adults during the design process. We combined this approach with the framework of Harvard University’s clinical and translational phases that provide a clear structure for evaluating new health programs before they are offered in the community. We based our online memory program on the empirically validated in-person Memory and Aging Program. The aim of the present study was to combine the agile development cycle with the clinical and translational phases framework to develop and pilot an online memory program tailored to the unique needs of older adults. Study 1 involved piloting individual program modules on site and integrating participant feedback into the program’s design to optimize usability. Study 2 involved two sequential pilots of the program accessed remotely to evaluate preliminary clinical outcomes and obtain feedback for iterative modifications. Plans for further validation and limitations are discussed. The successful application of the agile development cycle implemented in this series of studies can be adapted by others seeking to offer online content for targeted end users.
Associations among stress and language and socioemotional development in a low-income sample
Authors: Troller-Renfree Sonya V. , Hart Emma R. , Sperber Jessica F. , Fox Nathan A. , Noble Kimberly G. 
Published: March 2022

AbstractStress has been linked with children’s socioemotional problems and lower language scores, particularly among children raised in socioeconomically disadvantaged circumstances. Much of the work examining the relations among stress, language, and socioemotional functioning have relied on assessments of a single dimension of maternal stress. However, stress can stem from different sources, and people may appraise stressors differently. Taking a dimensional approach, this manuscript characterizes stress in multiple ways: as an overall composite; across the constructs of psychological appraisal vs. environmental stressors; and the independent contributions of a variety assessments. Data are from 548 mother–infant dyads (M= 13.14 months,SD= 2.11) who served as the control group for a poverty reduction clinical trial. Mothers completed questionnaires regarding the different types of stresses they may have experienced, as well as their children’s language and socioemotional development. Results indicate that, collectively, higher maternal report of stress is associated with lower reports of children’s socioemotional and language development. In addition, maternal psychological appraisals of stress were associated with both socioemotional and language development, whereas reports of environmental stressors were only associated with socioemotional development. Together, these findings suggest that maternal reports of stress are associated with lower maternal report of child development among low-income children.
Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health
Authors: Liu Sabrina R. , Sandman Curt A. , Davis Elysia Poggi , Glynn Laura M. 
Published: March 2022

AbstractPreconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers’ exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related to more infant negative emotionality at approximately 12 months old (M= 12.6,SD= .75). In contrast, maternal report of parenting self-efficacy when infants were 6 months old was related to lower levels of infant negative emotionality. Further, higher levels of parenting self-efficacy mitigated the relation between acculturative stress and negative emotionality. Preconception and prenatal exposure to sociocultural stress may be a risk factor for poor offspring mental health. Maternal and child health researchers, policymakers, and practitioners should prioritize further understanding these relations, reducing exposure to sociocultural stressors, and promoting resilience.
Association between Mode of Transportation and Survival in Adult Trauma Patients with Penetrating Injuries: Matched Cohort Study between Police and Ground Ambulance Transport
Authors: Abou Arbid Samer A. , Bachir Rana H. , El Sayed Mazen J. 
Published: March 2022

AbstractIntroduction:Police transport (PT) of penetrating trauma patients has the potential to improve survival rates. There are no well-established guidelines for PT of penetrating trauma patients.Study Objective:This study examines the association between survival rate to hospital discharge of adult penetrating trauma patients and mode of transport (PT versus ground ambulance [GA]).Methods:A retrospective, matched cohort study was conducted using the United States (US) National Trauma Data Bank (NTDB). All adult penetrating injury patients transported by police to trauma centers were identified and matched (one-to-four) to patients transported by GA for analysis. Descriptive analysis was carried out. The patients’ demographic and clinical characteristics were tabulated and stratified by the transport mode.Results:Out of the 733 patients with penetrating injuries, ground Emergency Medical Services (EMS) transported 513 patients and police transported 220 patients. Most patients were 16-64 years of age with a male (95.6%) and Black/African American race (79.0%) predominance. Firearm-related injuries (68.8%) were the most common mechanism of injury with the majority of injuries involving the body extremities (62.9%). Open wounds were the most common nature of injury (75.7%). The overall survival rate to hospital discharge was similar for patients transported by GA and by police (94.5% versus 92.7%; P = .343).Conclusion:In this study, patients with penetrating trauma transported by police had similar outcomes to those transported by GA. As such, PT in penetrating trauma appears to be effective. Detailed protocols should be developed to further improve resource utilization and outcomes.
Quality Not Quantity: Prioritizing the Management of Sedimentary Organic Matter Across Continental Shelf Seas
Authors: Smeaton C. , Austin W. E. N. 
Published: March 2022

AbstractDisturbance of marine sediments results in the remineralization of sedimentary organic matter (OM) and impacts upon natural burial processes. Management interventions which restrict or remove activities that cause seabed disturbance may offer effective strategies to protect the most vulnerable of these shelf sea OM stores, offering new opportunities to deliver climate mitigation actions. While the largest quantities of OM are often stored in the expansive offshore regions of continental shelves and might therefore suggest appropriate zones for management interventions to protect vulnerable OM stores, our results highlight that these offshore regions generally contain OM of low reactivity. Conversely, inshore and coastal sediments store significant quantities of highly reactive OM that is at greater risk of remineralization when disturbed. The marked spatial disparities between OM reactivity across shelf sea sedimentary environments highlights the need to focus emergent policy and future management interventions toward the protection of inshore and coastal sediments.
Variations in Wave Slope and Momentum Flux From Wave‐Current Interactions in the Tropical Trade Winds
Authors: Iyer Suneil , Thomson Jim , Thompson Elizabeth , Drushka Kyla 
Published: March 2022

AbstractObservations from six Lagrangian Surface Wave Instrument Float with Tracking drifters in January‐February 2020 in the northwestern tropical Atlantic during the Atlantic Tradewind Ocean‐atmosphere Mesoscale Interaction Campaign are used to evaluate the influence of wave‐current interactions on wave slope and momentum flux. At observed wind speeds of 4–12 ms−1, wave mean square slopes are positively correlated with wind speed. Wave‐relative surface currents varied significantly, from opposing the wave direction at 0.24 ms−1 to following the waves at 0.47 ms−1. Wave slopes are 5%–10% higher when surface currents oppose the waves compared to when currents strongly follow the waves, consistent with a conservation of wave energy flux across gradients in currents. Assuming an equilibrium frequency range in the wave spectrum, wave slope is proportional to wind friction velocity and momentum flux. The observed variation in wave slope equates to a 10%–20% variation in momentum flux over the range of observed wind speeds (4–12 ms−1), with larger variations at higher winds. At wind speeds over 8 ms−1, momentum flux varies by at least 6% more than the variation expected from current‐relative winds alone, and suggests that wave‐current interactions can generate significant spatial and temporal variability in momentum fluxes in this region of prevailing trade winds. Results and data from this study motivate the continued development of fully coupled atmosphere‐ocean‐wave models.
Importance of High‐Frequency (≤30‐day) Wind Variability to the Annual Climatology of the Surface Latent Heat Flux Inferred From the Global Tropical Moored Buoy Array
Authors: Yan Yunwei , Song Xiangzhou , Wang Guihua , Chen Changlin 
Published: March 2022

AbstractPrevious studies conducted based on reanalysis data sets have suggested that high‐frequency (≤30‐day) wind variability has a significant impact on the climatology of surface latent heat flux (LHF). The present study quantifies the impact of high‐frequency winds using field measurements derived from the global tropical moored buoy array (GTMBA) and, in turn, evaluates the performance of existing reanalysis products on capturing the role of these high‐frequency winds. The buoy observations demonstrate that high‐frequency winds at the n‐day (n = 1, 2, …, 30) timescale make a positive contribution to the annual climatology of LHF by nonlinearly enhancing the mean surface wind speed. Furthermore, this contribution increases as the timescale decreases, with maxima occurring at the 1‐day (subdaily) timescale. The subdaily winds contribute 4.6 W m−2, on average over all GTMBA sites. The largest contribution exceeds 10.0 W m−2 over the equatorial western Pacific Ocean. Hourly reanalysis products underestimate the contribution of the high‐frequency winds at timescales shorter than about a week, especially at the subdaily timescale, which is underestimated by approximately 50–60%. This finding suggests that an improvement in the performance of subdaily wind variability is needed to improve the fidelity of next‐generation reanalysis products.
Genetic influences on central and peripheral nervous system activity during fear conditioning
Authors: Kastrati G. , Rosén J. , Fredrikson M. , Chen X. , Kuja-Halkola R. , Larsson H. , Jensen K. B. , Åhs F. 
Published: March 2022

AbstractFear conditioning is an evolutionarily conserved type of learning serving as a model for the acquisition of situationally induced anxiety. Brain function supporting fear conditioning may be genetically influenced, which in part could explain genetic susceptibility for anxiety following stress exposure. Using a classical twin design and functional magnetic resonance imaging, we evaluated genetic influences (h2) on brain activity and standard autonomic measures during fear conditioning. We found an additive genetic influence on mean brain activation (h2 = 0.34) and autonomic responses (h2 = 0.24) during fear learning. The experiment also allowed estimation of the genetic influence on brain activation during safety learning (h2 = 0.55). The mean safety, but not fear, related brain activation was genetically correlated with autonomic responses. We conclude that fear and safety learning processes, both involved in anxiety development, are moderately genetically influenced as expressed both in the brain and the body.
mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a
Authors: Chen Ajuan , Jin Jian , Cheng Shasha , Liu Zezheng , Yang Cheng , Chen Qingjing , Liang Wenquan , Li Kai , Kang Dawei , Ouyang Zhicong , Yao Chenfeng , Bai Xiaochun , Li Qingchu , Jin Dadi , Huang Bin 
Published: March 2022

AbstractSenescence impairs preosteoblast expansion and differentiation into functional osteoblasts, blunts their responses to bone formation-stimulating factors and stimulates their secretion of osteoclast-activating factors. Due to these adverse effects, preosteoblast senescence is a crucial target for the treatment of age-related bone loss; however, the underlying mechanism remains unclear. We found that mTORC1 accelerated preosteoblast senescence in vitro and in a mouse model. Mechanistically, mTORC1 induced a change in the membrane potential from polarization to depolarization, thus promoting cell senescence by increasing Ca2+influx and activating downstream NFAT/ATF3/p53 signaling. We further identified the sodium channel Scn1a as a mediator of membrane depolarization in senescent preosteoblasts. Scn1a expression was found to be positively regulated by mTORC1 upstream of C/EBPα, whereas its permeability to Na+was found to be gated by protein kinase A (PKA)-induced phosphorylation. Prosenescent stresses increased the permeability of Scn1a to Na+by suppressing PKA activity and induced depolarization in preosteoblasts. Together, our findings identify a novel pathway involving mTORC1, Scn1a expression and gating, plasma membrane depolarization, increased Ca2+influx and NFAT/ATF3/p53 signaling in the regulation of preosteoblast senescence. Pharmaceutical studies of the related pathways and agents might lead to novel potential treatments for age-related bone loss.
Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis
Authors: Li Bopei , Chen Yeyang , Liang Liang , Wang Ye , Huang Weijia , Zhao Kun , Liu Siyu , Deng Guofei , Chen Junqiang 
Published: March 2022

AbstractGastric cancer (GC) is a heterogeneous disease with poor prognosis. Tumor-derived extracellular vesicles (EVs) assume a role in intercellular communication by carrying various molecules, including proteins, RNA, and DNAs, which has been identified to exhibit oncogenic effect in GC. Therefore, this research aimed to figure out whether tumor-derived EVs transmit c-Myc to orchestrate the growth and metastasis of GC. KCNQ1OT1, microRNA (miR)-556-3p and CLIC1 expression of GC tissues was detected through RT-qPCR. EVs were isolated from GC cells, followed by RT-qPCR and Western blot analysis of c-Myc expression in EVs and GC cells. Next, GC cells were incubated with EVs or transfected with a series of mimic, inhibitor, or siRNAs to assess their effects on cell viability, migrative, invasive, and apoptotic potential. Relationship among c-Myc, KCNQ1OT1, miR-556-3p, and CLIC1 was evaluated by dual-luciferase reporter assay. PI3K/AKT pathway-related proteins were assessed through Western blot analysis. KCNQ1OT1 and CLIC1 were highly expressed but miR-556-3p in GC tissues. c-Myc was high-expressed in tumor-derived EVs and GC cells. Mechanistically, c-Myc could induce KCNQ1OT1 expression, and KCNQ1OT1 bound to miR-556-3p that negatively targeted CLIC1 to inactivate PI3K/AKT pathway. Tumor-derived EVs, EVs-c-Myc, KCNQ1OT1 or CLIC1 overexpression, or miR-556-3p inhibition promoted GC cell proliferative, invasive, and migrative capacities but repressed their apoptosis through activating PI3K/AKT pathway. Collectively, tumor-derived EVs carrying c-Myc activated KCNQ1OT1 to downregulate miR-556-3p, thus elevating CLIC1 expression to activate the PI3K/AKT pathway, which facilitated the growth and metastasis of GC.
Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis
Authors: Wang Yi-Liang , Zhang Ying , Cai Da-Sheng 
Published: March 2022

AbstractThe purpose of the present study is to define the role of sevoflurane (SEV) in hepatic ischemia-reperfusion (I/R) injury as well as its underlying mechanism. Initially, hepatic I/R animal models and I/R hepatocyte models were established in C57BL/6 mice and normal mouse hepatocytes (BNL CL.2) after SEV preconditioning, respectively, followed by detection of microRNA-124-3p (miR-124-3p), TRAF3, and CREB expression by RT-qPCR and Western blot analysis. In addition, miR-124-3p, TRAF3 and CREB expression in hepatocytes was altered to identify their roles in modulating the levels of glutathione transferase (GST), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and inflammation-related factors and hepatocyte apoptosis by ELISA and flow cytometry respectively. The effects of SEV on the miR-124-3p/TRAF3/CREB axis were also verified in vitro and in vivo. IP assay was performed to verify the effect of TRAF3 on CREB ubiquitination in BNL CL.2 cells, and the cycloheximide (CHX) intervention experiment to detect the stability of CREB protein. SEV augmented the miR-124-3p expression in I/R animal and cell models. Moreover, SEV was observed to suppress I/R-induced liver damage, GST, ALT, and AST levels, hepatocyte apoptosis and inflammation. Overexpression of miR-124-3p resulted in alleviation of hepatic I/R injury, which was countered by TRAF3 overexpression. miR-124-3p targeted TRAF3, while TRAF3 promoted CREB ubiquitination and reduced protein stability of CREB. SEV could impede I/R-induced liver damage, GST, ALT, and AST levels, hepatocyte apoptosis and inflammation via mediation of the miR-124-3p/TRAF3/CREB axis in vitro and in vivo. Collectively, SEV may upregulate miR-124-3p to inhibit TRAF3 expression, thereby reducing the ubiquitination and degradation of CREB, alleviating hepatic I/R injury.