bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaksi sosial pada kalangan mahasiswi bercadar di lingkungan kampus
Authors: Praja Wina Nurhayati , Pandu Hyangsewu  , Isni Nurazizah  
Published: November 2022

adar atau dalam bahasa arab disebut An-Niqab adalah sesuatu yang berguna untuk menutupi seluruh wajah perempuan, kecuali kedua mata atau sesuatu yang tampak disekitar mata. Muslimah bercadar menjadi menarik untuk diteliti karena cara mereka menjalankan perintah Allah yang berbeda dengan muslimah pada umumnya. Sebagai manusia, wanita bercadar juga membutuhkan komunikasi, karena manusia adalah makhluk sosial yang berarti tidak dapat hidup tanpa orang lain. Dorongan atau motif sosial pada manusia, mendorong manusia mencari orang lain untuk mengadakan hubungan atau interaksi sehingga memungkinkan terjadi interaksi antara manusia satu mampu menampilkan diri sesuai dengan norma yang berlaku. Penelitian ini dilaksanakan di lingkungan kampus Universitas Pendidikan Indonesia, Bumi Siliwangi. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisa apa yang melatarbelakngi penggunaan cadar dikalangan Mahasisiwi dan bagaimana interaksi sosial mahasisiwi bercadar di Kampus UPI. Teknik penentuan sampel secara purposive sampling menetapkan jumlah subjek penelitian sebanyak 5 orang. Penulis menggunakan metode deskriptif kualitatif dengan instrumen data adalah observasi, wawancara dan studi kepustakaan.
Berdasarkan hasil dari penelitian, penulis menemukan adanya beberapa alasan yang melatar belakangi penggunaan cadar dikalangan mahasiswi, yaitu pemahaman dalam beragama, merubah diri untuk menjadi muslimah yang lebih baik, kemauan dalam diri sendiri untuk menggunakan cadar serta pengaruh dari teman dan lingkungan pergaulan yang baik juga. Interaksi Mahasiswi bercadar dengan lingkungan yang saat ini banyak bermunculan anggapan negatif dengan cadar. Penulis menemukan bahwa interaksi mahasiwi bercadar dengan teman satu kelompok atau teman perempuan yang sudah lama berinteraksi dengan mahasisiwi bercadar selalu mengalami kesulitan untuk mengenali temannya sendiri yang menggunakan cadar, kesulitan mengenali seseorang yang tidak terlihat wajah, interaksi mahasiswi bercadar dengan teman lawan jenis akan membatasi diri dan mengatur jarak atau hanya sekedar tegur sapa.
In vitro isolation and expansion of neural stem cells NSCs
Authors: Mohammad Maeda H. , Almzaien Aous Kahtan , Al-Joubory Ahmad A. , Al-Shammari Ahmed M. , Ahmed Ayser A. , Shaker Hiba K. , Abedalsattar Aseel K. 
Published: November 2022

الخلايا الجذعية العصبية (NSCs) هي خلايا مولدة لديها القدرة على التجديد الذاتي والقدرة على التمايز إلى خلايا عصبية نجمية astrocytes ، وخلايا عصبية قليلة التفرع oligodendrocyte، و خلايا عصبية neuron . في هذه الدراسة تم عزل الخلايا الجذعية في المختبر ، وتنميتها في المختبر ، وتحديد هويتها ، ومن ثم انتاج الخلايا الجذعية العصبية وحفظها بالنيتروجين السائل كمصدر خلايا ناجح لاستخدامها لاحقا في التجارب العلاجية. تم استخدام نخاع عظم الفأر كمصدر للخلايا الجذعية العصبية في هذه الدراسة. أظهرت نتائج دراسة الشكل المظهري والكيمياء المناعية للخلايا المعزولة أنه يمكننا إنتاج الخلايا الجذعية العصبية NSCs بنجاح والحفاظ على تجديدها الذاتي وتشكيلها بنجاح في الغلاف العصبي ولتمريرات متعددة. تم الحفاظ على الشكل المظهري للخلايا الناتجة وتخزينها في النيتروجين السائل لتكون مصدرا جاهزا للاستخدام في التجارب كنموذج لعلاج الاضطرابات العصبية.
Exploring computational techniques for simulating residual stresses for thin wall multi-joint hexagon configurations for a laser directed energy deposition process
Authors: Mohajernia Bita , Urbanic Jill 
Published: November 2022

Abstract
Laser cladding is a directed energy deposition process, and can lead to high residual stresses, which can compromise the quality of the specimen. As a result, it is crucial to accurately predict and investigate the residual stress distribution in cladded parts and understand the mechanism of formation. In this study a thermo-mechanical metallurgical simulation model of the laser cladding process was developed for three different path strategies with respect to the deposition sequence and direction for a thin wall hexagon with inner junctions to investigate the formation of residual stress. The study was performed for single and multilayer scenarios. Two types of computational techniques, the detailed transient approach and the imposed thermal cycle approach, was performed and comparisons conducted. Consistent results were observed when comparing the resultant stress patterns for the single layer; subsequently, the imposed thermal cycle method was applied for the five layer models. A preheat scenario is explored. This reduced the computational cost significantly, but the stress patterns were not similar. This indicates that building up worn regions at the top of a thin walled component, such as a roll die, needs to be investigated further as unique issues have been highlighted. The differences between the implemented computational techniques are described as well as the advantages and disadvantages of each. Knowledge obtained from these case studies provides a foundation for efficient and rapid optimization of laser cladding processes, with the aim of minimizing residual stress in both simple and complex laser cladding structures.
Age-specific information resources to address the needs of young people with stroke: a scoping review protocol
Authors: Gopaul Urvashy , Charalambous Marina , Thilarajah Shamala , Kwah Li Khim , Chapman Sherita , Bayley Mark , Demers Marika 
Published: November 2022

Abstract
Background and aims Young people with stroke (YPwS) persistently experience challenges with disability, social reintegration, employment and financial stability to provide for themselves and their families. The aims of this scoping review are to: 1) identify and collate information resources for YPwS and evidence-based self-managements programs and,2) identify gaps in age-specific resources available for YPwS after traditional rehabilitation services have ended and/or who are returning to live in the community.
Methods We will include both qualitative and quantitative studies, including all study designs. Participants will be community-dwelling adults aged between 18–65 years with a clinical diagnosis of stroke. We will include information resources and evidence-based self-managements programs for YPwS. Search terms will include stroke, young people, community-dwelling. We will search electronic databases such as MEDLINE. The reference lists of included studies, systematic reviews and stroke guidelines and stroke specific websites will also be searched. We will also contact Stroke Support Organizations and international/national allied health professional organisations to gather information resources about YPwS. We will also conduct a comprehensive environmental scan of additional resources using the search engine Google. The titles, abstracts, full-text articles and contents of the resources identified by the search will be assessed against the inclusion and exclusion criteria to identify potentially relevant resources.
Results and Conclusions Existing resources and self-management programs will be collated and categorized according to the type of needs addressed such as physical, emotions, activities of daily living, information, relationships and social needs as well as the key gaps identified.
Dysregulation of CELF4 splicing factor in pancreatic neuroendocrine tumors enhances aggressiveness and alters mTOR pathway and everolimus response
Authors: Castano Justo P , Alors-Perez Emilia , Pedraza-Arevalo Sergio , Agraz-Doblas Antonio , Blázquez-Encinas Ricardo , García-Vioque Víctor , M Yubero-Serrano Elena , Sánchez-Frías Marina E. , Serrano-Blanch Raquel , Gálvez-Moreno María Ángeles , Gracia-Navarro Francisco , Gahete Manuel D. , Arjona-Sánchez Álvaro , Luque Raúl M. , Ibáñez-Costa Alejandro 
Published: November 2022

Abstract
Background
Pancreatic neuroendocrine tumors (PanNETs) comprise a highly heterogeneous group of rare tumors, with growing incidence. Recent molecular analyses provided a precise picture of their genomic and epigenomic landscape. Splicing dysregulation is increasingly regarded as a novel cancer hallmark influencing all key tumor features. In this context, we have previously demonstrated that splicing machinery is markedly dysregulated in various cancers, including PanNETs. Here, we aimed to elucidate the molecular features and functional implications pertaining to one of the most altered splicing factors in PanNETs, CELF4.
Methods
CELF4 expression levels were determined in a cohort of 20 PanNET patients, comparing tumor and non-tumoral adjacent tissue, used as reference. RNA-Seq dataset was analyzed to explore CELF4-linked interrelations among clinical features, gene expression, and splicing event profiles. Two PanNET model cell lines, BON-1 and QGP-1, were employed to assess CELF4 function in vitro, including a detailed mTOR phospho-antibody array, and in vivo in BON-1-xenografted mice.
Results
PanNETs display markedly upregulated CELF4 expression levels, which closely associate with relevant malignancy features, specific expression of key tumor players (e.g., TP53), and distinct splicing event profiles. Functionally, modulation of CELF4 expression influenced PanNET cell lines proliferation in vitro, while CELF4 silencing in vivo reduced BON-1 xenograft tumor growth. Interestingly, CELF4 silencing enhanced the antiproliferative effect of the mTOR inhibitor everolimus in PanNET cells. Furthermore, detailed analysis of this core signaling pathway under CELF4 silencing showed changes in phosphorylation of the molecular components of the mTOR pathway.
Conclusions
Our results demonstrate that the splicing factor CELF4 is dysregulated in PanNETs, where it can influence tumor development and aggressiveness, likely by modulating mTOR pathway. These novel findings invite to explore in further detail this splicing factor as actionable therapeutic target in PanNETs.
Three-Dimensional Digital Visualization System Assisted Vitrectomy for Infectious Endophthalmitis
Authors: Guan Lina , Chen Jiayu , Zhang Zhengpei , Ji Sujuan , Liu Yalu , Li Suyan , Liu Haiyang 
Published: November 2022

Abstract
Purpose: To present our experiences and surgical efficacy of the three-dimensional(3D)visualization system in endophthalmitis vitrectomy.
Methods: 11 cases of endophthalmitis had undergone NGENUITY® 3D Visualization System assisted23-gauge transconjunctival vitrectomy, by a same surgeon at Xuzhou First People’s Hospital between 1 March 2020 and 31 March 2022. The efficacy of vitrectomy , best-corrected visual acuity (BCVA), intraoperative illumination, and comfort of the surgeon was investigated.
Results: The vitrectomy was finished in all cases with lower intensity of intraoperative illumination on the 3D visualizationsystem without any complications attributed to the visualization system, and none of them were abdicated or converted to the conventional microscope. All of the patients were cured after operation combined with antibiotics therapy, consistent with significantly improved BCVA(t = 4.039, p = 0.0024).
Conclusion: 3D visualizationsystem with advantages of clearer intraoperation visualization and optimized ergonomic design, is suitable for a variety of vitreoretinal surgery with good safety and efficacy, especially in the complicated and long-lasting endophthalmitis surgeries.
Case-matched radiological and clinical outcome evaluation of interlaminar versus microsurgical decompression of lumbar spinal stenosis​
Authors: Saravi Babak , Ülkümen Sara , Lang Gernot , Couillard-Despres Sebastien , Hassel Frank 
Published: November 2022

Abstract
Purpose
Endoscopic spine surgery is a globally expanding technique advocated as less invasive for spinal stenosis treatment compared to the microsurgical approach. However, evidence on the efficiency of interlaminar full-endoscopic decompression (FED) vs. conventional microsurgical decompression (MSD) in patients with lumbar spinal stenosis is still scarce. We conducted a case-matched comparison for treatment success with consideration of clinical, laboratory, and radiologic predictors.
Methods
We included 88 consecutive patients (FED: 36/88, 40.9%; MSD: 52/88, 59.1%) presenting with lumbar central spinal stenosis. Surgery-related (operation time, complications, length of stay (LOS), American Society of Anesthesiologists Physical Status (ASA) score, C-reactive protein (CRP), white blood cell count, side of approach (unilateral/bilateral), patient-related outcome measures (PROMs) (Oswestry Disability Index (ODI), Numeric Rating Scale of Pain (NRS; leg-, back pain), EuroQol questionnaire (eQ-5D), Core Outcome Measures Index (COMI)), and radiological (dural sack cross-sectional area, Schizas score (SC), left and right lateral recess heights, and facet angles, respectively) parameters were extracted at different time points up to 1-year follow-up. The relationship of PROMs was analyzed using Spearman’s rank correlation. Surgery-related outcome parameters were correlated with patient-centered and radiological outcomes utilizing a regression model to determine predictors for propensity score matching.
Results
Complication (most often residual sensorimotor deficits and restenosis due to hematoma) rates were higher in the FED (33.3%) than MSD (13.5%) group (p < 0.05), while all complications in the FED group were observed within the first 20 FED patients. Operation time was higher in the FED, whereas LOS was higher in the MSD group. Age, SC, CRP revealed significant associations with PROMs. We did not observe significant differences in the endoscopic vs. microsurgical group in PROMs. The correlation between ODI and COMI was significantly high, and both were inversely correlated with eQ-5D, whereas the correlations of these PROMs with NRS findings were less pronounced.
Conclusions
Endoscopic treatment of lumbar spinal stenosis was similarly successful as the conventional microsurgical approach. Although FED was associated with higher complication rates in our single-center study experience, the distribution of complications indicated surgical learning curves to be the main factor of these findings. Future long-term prospective studies considering the surgical learning curve are warranted for reliable comparisons of these techniques.
Carbon disulfide removal from gasoline fraction using zinc-carbon composite synthesized using microwave-assisted homogenous precipitation.
Authors: Sakr Ayat A.-E. , Amr Noran , Bakry Mohamed , El-Azab Waleed , Ebiad Mohamed 
Published: November 2022

Abstract
Carbon disulfide (CS2) is one of the sulfur components that are naturally present in petroleum fractions. Its presence causes corrosion issues in the fuel facilities and deactivates the catalysts in the petrochemical processes. It is a hazardous component that negatively impacts the environment and public health due to its toxicity. This study used zinc-carbon (ZC) composite as a CS2 adsorbent from the gasoline fraction model component. The carbon is derived from date stone biomass. The ZC composite was prepared via a homogenous precipitation process by urea hydrolysis. The physicochemical properties of the prepared adsorbent are characterized using different techniques. The results confirm the loading of zinc oxide/ hydroxide carbonate and urea derived species on the carbon surface. The results were compared by the parent samples, raw carbon, and zinc hydroxide prepared by conventional and homogeneous precipitation.
The CS2 adsorption process was performed using a batch system at atmospheric pressure. The effects of adsorbent dosage and adsorption temperatures have been examined. The results indicate that ZC has the highest CS2 adsorption capacity (124.3 mg.g-1 at 30˚C) compared to the parent adsorbents and the previously reported data. The kinetics and thermodynamic calculations results indicate the spontaneity feasibility of the CS2 adsorption process.
An experimental study of mitigation of fire hazards of flash powder by adding Mono Ammonium Phosphate as a solid inertant for explosive waste disposal in firework industries
Authors: Arumugachamy Azhagurajan , Pandian Prakash Lakshmana 
Published: November 2022

Abstract
In firework industries, flash powder which is a chemical mixture is used for crackers manufacturing. Flash powder is a highly inflammable chemical mixture. It consists of Aluminium, Sulphur, and Potassium Nitrate. In the manufacturing, daily wastes are collected and burned in the open pit. This leads not only to air pollution but also causes many accidents. There seems to exist no satisfactory method of waste disposal that is suitable for explosive waste. Here, the author has suggested a novel method according to which the explosives can be converted into an inert substance by adding solid inertants and then can be safely disposed by land fill. A solid inertant mono-ammonium phosphate (MAP) chemical was utilized to lower the flash powder's sensitivity. MAP is a fire extinguishing agent which can also be used as a fertilizer for the soil. In this work, various tests like layer ignition temperature, friction and impact sensitivity, plant growth test and decomposition test were conducted for the MAP mixed flash powder. From the various tests, it has been concluded that 50% MAP mixed flash powder would be safe to handle and that 75% mixed flash powder does not decompose at all weather conditions. After land filling, soil is not polluted, and it could be used for agriculture purpose.
Ulinastatin ameliorates acute pancreatitis and associated intestinal and pulmonary injury by inhibiting NLRP3 inflammatory vesicles and affecting intestinal flora composition and metabolic pathways in rat
Authors: Xu Lin , Zhang Jinglan , Guo Junqi , Liu Chao , Yang Jing , Yu Yang , Liu Wen , Zhu Guochao 
Published: November 2022

Abstract
Background
Acute pancreatitis (AP) is a common and potentially fatal disease, and severe AP can lead to systemic or local complications, such as enterocolitis and lung injury. The purpose of this study was to explore the mechanism of ulinastatin inhibition of Acute pancreatitis (AP) and its complications, and the effect of ulinastatin on intestinal flora and intestinal metabolism in AP rats.
Methods
Establish AP rat model, and detect serum lipase and α- Amylase activity content, dry/wet specific gravity of pancreas, and plasma Content of IL-1 β, TNF- α, IL-6, IL-10 and D-lactic acid, Histopathology was used to analyze the pathological changes of pancreas, intestine and lung, and Western blot was used to detect NLRP3, Caspase 1 and IL-1 β expression in pancreas, analysis of the protection of ulinastatin on intestinal mucosal barrier, analysis of the impact of ulinastatin on species richness and biodiversity of intestinal flora in rats with acute pancreatitis, analysis of the impact of ulinastatin on intestinal metabolites in AP rats, and analysis of the correlation between common differential metabolites and dominant flora.
Results
The results indicate that ulinastatin inhibited the conversion of pro-IL-1β to mature IL-1β by inhibiting NLRP3 and Caspase 1, the constituent proteins of NLRP3 inflammatory vesicles, and thereby suppressed the release of pancreatic edema, neutrophil infiltration and inflammatory cytokines IL-1β, TNF-α and IL-6 induced by AP, and increased the level of anti-inflammatory factor IL-10. This inhibitory mechanism of inflammatory response of ulinastatin also has the same inhibitory effect on enteritis and pneumonia caused by AP. Ulinastatin protects the intestinal mucosal barrier by increasing the levels of tight link proteins (Claudin, Occludin and ZO-1) in AP rats. Ulinastatin shifted the dominant intestinal flora of AP rats to Bacteroidaceae-Enterobacteriaceae, which may shift the fatty acid acquisition pathway in the mouse intestine from synthetic fatty acids to catabolic long- and medium-chain fatty acids. This regulatory effect on intestinal flora would further affect metabolic pathways such as amino acid metabolism and vitamin B6 metabolism in AP rats.
Conclusions
Ulinastatin can inhibit NLRP3 inflammatory vesicles and related proteins, and it can also affect intestinal flora composition and metabolic pathways in rats to improve acute pancreatitis and related intestinal and lung injuries
Hypermethylation of ACADVL is involved in high-intensity interval training-associated reduction of cardiac fibrosis in heart failure patients
Authors: Hsu Chih-Chin , Wang Jong-Shyan , Shyu Yu-Chiau , Fu Tieh-Cheng , Juan Yu-Hsiang , Yuan Shin-Sheng , Wang Chao-Hung , Yeh Chi-Hsiao , Liao Po-Cheng , Wu Hsin-Yi , Hsu Pang-Hung 
Published: November 2022

Abstract
Background

Emerging evidence suggests that DNA methylation can be affected by physical activities and is associated with cardiac fibrosis. The translational research examined the implications of DNA methylation presentations behind high-intensity interval training (HIIT) effects on cardiac fibrosis in patients with heart failure (HF).

Methods

Twelve HF patients were included and received cardiovascular magnetic resonance imaging with late gadolinium enhancement for cardiac fibrosis severity and cardiopulmonary exercise test for peak oxygen consumption (⩒O2peak). Afterwards, they underwent 36 sessions of HIIT at alternating 80% and 40% of ⩒O2peak for 30 min per session in 3–4 months. Human serum from 11 participants, linking cell biology to clinical presentations, was used to investigate exercise effects on cardiac fibrosis. Primary human cardiac fibroblasts (HCFs) incubated in patient serum for cell behaviors, proteomics (n = 6) and DNA methylation profiling (n = 3) were performed. All measurements were followed after completing HIIT.

Results

An increase of ⩒O2peak along with decreased b-type natriuretic peptide was observed after HIIT. Significantly decreased left ventricle (LV) myocardium fibrosis by 8–12% at middle and apical myocardial segments, decreased LV volume, and increased LV ejection fraction were identified after HIIT. 49 in 1222 identified proteins were significantly involved in the HIIT-induced altered HCF activities. A significant hypermethylation on acyl-CoA dehydrogenase very long chain (ACADVL) gene was identified. Downstream caspases-mediated actin disassembly and cell death pathway were activated after HIIT.

Conclusions

HIIT is associated with hypermethylation of ACADVL to impede HCF activities. This exercise-associated epigenetic reprogramming may contribute to reduce cardiac fibrosis and furthermore, promotes cardiorespiratory fitness in HF patients.

Trial registration

: NCT04038723. Registered 31 July 2019, https://clinicaltrials.gov/ct2/show/NCT04038723.