bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roles of perception of similarities, continuum beliefs and social distance towards a person with schizophrenia: A German representative sample study
Authors: Buckwitz Vincent , Juergensen Vanessa , Goebel Mirjam , Schomerus Georg , Speerforck Sven 
Published: September 2022

Abstract

People with schizophrenia are often perceived as fundamentally different from oneself, a notion closely tied to mental illness stigma. The current study examines the interrelation between perception of similarities (semantic differential: similar-different scale) and continuum beliefs in the context of schizophrenia-related stigma (desire for social distance) in a German population sample (N = 760). Perception of similarities and continuum beliefs were significantly associated with lower desire for social distance explaining about 12% variance in an additive regression model. Continuum beliefs partially mediated the relation of perception of similarities and desire for social distance. Implications for mental illness stigma interventions are discussed.
Fontan Surgery Instead of Biventricular Repair in Complex Cardiac Anomalies: A Good Alternative
Authors: Polat Ahmet Bülent , Ertürk Murat , Uzunhan Ozan , Karademir Nur , Öztarhan Kazım 
Published: September 2022

Abstract
Background
The Fontan operation has improved the survival of children born with congenital heart disease with single ventricle physiology. The most widely adopted variations of the Fontan procedure are the extracardiac conduit (ECC), the lateral tunnel (LT) ve the intra/extracardiac conduit with fenestration. Despite advances in the treatment and prevention of early and late complications that may develop after Fontan surgery, morbidity still remains an important problem.
Methods
304 patients who underwent Fontan surgery in our center between 1995–2022 were included in our study. The complications that developed in patients who underwent primary Fontan or lateral tunnel surgery and extracardiac conduit Fontan application were compared.
Results
Classic Fontan surgery and lateral tunnel surgery were performed in 26 of the patients, and extracardiac Fontan surgery was performed in 278 patients. 218 of 304 cases were patients with single ventricular pathology. 86 cases were patients with two ventricular morphologies but complex cardiac pathology. When complications between Fontan procedures were compared in our study, prolonged pleural effusion was found more frequently in patients with extracardiac disease after Fontan surgery.
Conclusion
There are unresolved questions regarding the choice of Fontan procedures and their impact on complication development. Palliative surgical operations aimed at the preparation of the fontan circulation lead to the preparation of the pulmonary vascular bed and the preservation of ventricular function. Early and long-term complications in Fontan surgery affect the survival of patients. In our study, we wanted to contribute to the literature by presenting our 27 years of experience in Fontan surgery.
Construction of Actinomycetes complex flora in degrading corn straw and its degradation effect evaluation
Authors: xiaofei Xiaofei , QI Yuena , Lian Jie , Song Jie , Zhang Shuai , Zhang Guang , Fan Jing , Zhang Na 
Published: September 2022

Abstract

As a kind of agricultural waste, corn straw internal lignocellulose content is higher, but it is difficult to be used efficiently because of its difficult degradation. In this experiment, three cellulose-degrading actinomycetes were constructed as complex flora, then the cellulose degradation conditions and degradation activity were optimized and evaluated. The results showed that when the complex flora was inoculated into the fermentation medium with pH of 7, volume fraction of 3%, and the degradation rate of corn straw could reach 38.24% after 5 d of fermentation at 28°C and 180 rpm. Cellulose, hemicellulose and lignin in corn straw were degraded by 33.97%, 34.08%, and 21.52%, respectively. The results of scanning electron microscopy showed that the waxy layer on the surface of corn straw was thinned and gradually disappeared by the fermentation of complex flora. Fourier transform infrared spectroscopy results showed that the complex flora could change the internal functional groups of corn straw in different fermentation periods. The detected compounds in fermentation system indicated that corn straw were efficiently degraded. According to the above results, the constructed complex flora had a higher ability to degrade corn straw, and provided research ideas for the development and utilization of biomass resources.
Analysis of global and net radiation fluxes in relation to surface albedo at DACCIWA site in Ile-Ife, southwest Nigeria
Authors: Ajao Adewale Iyiola , Abiye Olawale Emmanuel , Agboola Akeem Babatunde 
Published: September 2022

Abstract

Measurements of global solar and net radiation fluxes were made above a grass-covered surface at DACCIWA site in a tropical location, Ile-Ife, southwest Nigeria for a period of three years (2017 - 2019). The radiation data sets were obtained from a four-component net radiometer (model NR01). Observations were made for cases of clear sky and cloudy conditions during the measurement period. The results showed considerable fluctuations of both radiation fluxes occurring during the period of measurements at the location. For clear sky conditions, the magnitudes of global and net radiation fluxes were higher than those observed for cloudy conditions due to attenuation by clouds and aerosols. For the period of observation, the highest radiation flux values occurred in 2018 while the lowest were observed in 2017. The daily surface albedo (𝛼) values ranged from 0.16 to 0.22 at the site. Empirical relationships obtained for global solar and net radiation are 𝑅𝑁 = 0.754 𝑅𝐺 – 17.4 Wm-2 and 𝑅𝑁 = 0.657 𝑅𝐺 - 32.7 Wm-2 for wet and dry seasons respectively. Based on the empirical relationships, daily net and global solar radiation can be obtained when measurements like these are not available. Linear relationships between 𝑅𝑁 and 𝑅𝐺 show that for all days (cloudy and clear sky conditions), average 𝑅𝑁 is about 65 % of 𝑅𝐺, and about 50 % of 𝑅𝐺 for clear sky conditions at the location.
Identifying the Role of NUDCD1 in Human Tumors from Clinical and Molecular Mechanisms
Authors: Han Bin , He Jinsong , Li Yuanting , Chen Qing , Yuan Min , Zeng Xi , Zeng Yan , He Meibo , Feng Dan , Ma Daiyuan 
Published: September 2022

Abstract
Purpose
Cancer is a major public health condition characterized by high morbidity and mortality. NUDCD1 (NudC domain-containing 1) is abnormally activated in multiple tumors and has been identified as a cancer antigen. But there is still no pan-cancer analysis available for NUDCD1 in human cancers.
Methods
The role of NUDCD1 across multiple tumors was explored using data from the public databases including HPA, TCGA, GEO, GTEx, TIMER2, TISIDB, UALCAN, GEPIA2, cBioPortal, GSCA and so on.
Results
NUDCD1 was highly expressed in most tumors and its levels were associated with the prognosis of cancer patients. Multiple genetic and epigenetic features of NUDCD1 exist in different cancers such as uterine corpus endometrial carcinoma or kidney renal papillary cell carcinoma. NUDCD1 was associated with expression levels of recognized immune checkpoints (anti-CTLA-4) and immune infiltrates (e.g., CD4 + and CD8 + T cells) in some cancers. Moreover, NUDCD1 correlated with the CTRP and GDSC drug sensitivity and acted as a link between chemicals and cancers. The functional mechanisms of NUDCD1 included RNA metabolism- and protein processing-associated functions. Importantly, NUDCD1-related genes were enriched in several tumors (e.g., COAD, STAD and ESCA) and affected apoptosis, cell cycle and DNA damage cancer-related pathways. Furthermore, expression, mutation and copy number variations for the gene sets were also associated with prognosis.
Conclusions
NUDCD1 was involved in diverse biological processes and it influenced the occurrence and development of cancers through diverse underlying mechanism. This first pan-cancer analysis for NUDCD1 provides a comprehensive understanding about its roles across various cancer types.
Non-carcinogenic Health Risk Assessment and Predicting of Organic and Heavy Metal Pollution of Groundwater around Osisioma, Nigeria, using Artificial Neural Networks and Multi-Linear Modeling Principles
Authors: Chigoziem Akakuru Obinna , Uzoma Njoku Benedict , Uchechukwu Obinna-Akakuru Annabel , Akudinobi Bernard E. , Philip Obasi , Godwin Aigbadon , Bright Onyeanwuna Uzochi 
Published: September 2022

Abstract

Non-carcinogenic health risk assessment and predicting of organic and heavy metal pollution of groundwater around Osisioma, Nigeria, using Artificial Neural Networks and Multi-Linear Modeling Principles has been done. 30 groundwater samples were collected systematically and analyzed for organic and heavy metal pollutants. The results of the analysis showed that the heavy metals and organic pollutants within the study area contributed to the pollution of groundwater resources in the locality. However, copper, ethylbenzene, xylene and toluene were within the recommended standard, whereas arsenic, iron, chromium, lead, and benzene were above the recommended standard for drinking water. Correlation matrix and principal component analysis assessment indicated weak correlation and that organic pollutants were major contributors to the loadings. The Contamination factor, Pollution load index, Metal pollution index, Geoaccumulation index, Potential ecological risk index, Elemental Contamination Index, and overall Metal Contamination Index showed no significant pollution, whereas the Heavy Metal Evaluation Index, Pollution Index of Groundwater results showed worrisome impact of the anthropogenic activities on the groundwater quality. Health risk assessment showed that children are more at risk than adults as it related to taking polluted water. MLR models performed better than the ANN. Seven (7) mathematical models were generated for the prediction of pollution indices. Based on the results, this study recommends regular monitoring of groundwater resources and the integration of ANN and MLR modeling approaches for the prediction of pollution indices.
Synthesis, structural characterization and effect of surface modification on magnetization of hybrid manganese ferrite nanoparticle
Authors: Dan Shabnam , Chattree Amit , Naskar Jishnu , Kamsonlian Suantak 
Published: September 2022

Abstract

Paramagnetic Poly-methyl methacrylate (PMMA) and Poly ethylene glycol (PEG) functionalized manganese ferrite (PMMA-PEG-MF) nanoparticles were synthesized through a facile and efficient method. The resulting nanoparticles (NPs) were characterized using PSA, EDX, FT-IR, TEM, XRD, SEM, TGA and VSM techniques. The PMMA-PEG-MF NPs were nanocrystalline and depicted plate like particles with a mean size of around 70 nm as compared to the size of the MnFe2O4 nanoparticles which was observed to be 66 nm. The EDX validated the existence of metal ions and the modifiers (polymethylmethacrylate and polyethylene glycol) in the NPs. The FTIR confirmed the functionalization of MnFe2O4 NPs with PMMA and PEG. The XRD studies revealed that the synthesized MF and PMMA-PEG-MF NPs were crystalline and had a cubic spinel structure with a crystallite size of 14.64 nm and 14.42 nm and lattice parameter was calculated to be 6.20 Å and 3.90 Å respectively. The SEM micrograph revealed highly agglomerated nanostructures in the MnFe2O4 NPs; however, the extent of agglomeration reduced significantly post modification with PMMA and PEG. The TGA study exhibited an overall weight loss of 2.86% and 25.11% for MnFe2O4 and PMMA-PEG-MF NPs respectively. Magnetization measurements showed a substantial reduction in the saturation magnetization (Ms) and magnetic moment (µB) after modifying MnFe2O4 with PMMA and PEG. A saturation magnetization of 0.0056 emu/g was derived for PMMA and PEG modified MnFe2O4 NPs, as compared to 23 emu/g for MnFe2O4 magnetic NPs, suggesting paramagnetic behaviour of the synthesized NPs.
Morphological identification, molecular characterization and optimization of cultivation for Acrobeloides maximus species extracted from bitter gourd (Momordica charantia) field at Gujarat, India.
Authors: Thakar Shweta Prakashkumar , Chauhan Sunita , Highland Hyacinth , George Linz-Buoy 
Published: September 2022

Abstract

Background
Free-living nematodes are very important part of agricultural soil ecosystems, especially members of the Cephalobidae family. Morphological and morphometric analysis is efficient for genus-level classification of Cephalobidae members, but to achieve species-level identification, molecular characterization is imperative.
Methods and Results
The nematodes extracted from the collected soil of the bitter gourd field were cultivated on NGM (nutrient growth medium) agar plates under standardized laboratory conditions. The morphological characteristics of 42 females and 6 males were captured under a digital microscope and processed using the ImageJ analysis tool for De-Man measurements and compared with previously submitted databases. DNA barcoding was carried out with the 18S small RNA subunit gene, and the resulting sequence was then processed to BLASTN after alignment and annotation. The phylogenetic tree was constructed from the processed data files and further evaluated by branch lengths and bootstrap values. Blast analysis showed 98% similarity with the A. maximus strain, which was also supported by high bootstrap values (96%). Acrobeloides maximus was identified based on morphological features described by Throne, 1925 and confirmed by molecular characterization.
Conclusion
The nematodes collected from the soil sample were cultivated and identified as A. maximus by a combined approach of morphological, pictorial, morphometric, and molecular analysis, which may further be used in the future identification of Acrobeloides spp. To our knowledge, this is the first recorded A. maximus from the bitter gourd field of Gujarat, India. Pictogram and measurement of eggs inside the female body is also shown for A. maximus for the first time.
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response
Authors: Lin Nan , Sun Liankun , Chai Jiannan , Qi Hang , Zhao Yuanxin , Ma Jiaoyan , Xia Meihui , Xiaoqing Hu 
Published: September 2022

Abstract
Drug resistance remains a challenge in ovarian cancer. In addition to aberrant activation of relevant signaling pathways, the adaptive stress response is emerging as a new spotlight of drug resistance in cancer cells. Stress granules (SGs) are one of the most important features of the adaptive stress response, and there is increasing evidence that SGs promote drug resistance in cancer cells. In the present study, we compared two types of ovarian cancer cells, A2780 and SKOV3, using the dual PI3K/mTOR inhibitor, PKI-402. We found that SGs were formed and SGs could intercept the signaling factor ATF5 and regulate the response of mitochondrial unfolded protein(mtUPR)in A2780 cells. Therefore, exploring the network formed between SGs and membrane-bound organelles, such as mitochondria, may provide new insight into the mechanisms of action of antitumor drugs.
Fruit and vegetable intake and the risk of cataract: insights from the UK Biobank Study
Authors: Fan Huiya , Han Xiaotong , Shang Xianwen , Zhu Zhuoting , Mingguang He , Xu Guihua , Chen Zilin , Deng Ruidong 
Published: September 2022

Abstract
Purpose: To investigate the association between fruit and vegetable (F&V) intakeand the risk of cataract.
Design: Prospective cohort study.
Methods: We included 72,160 participants who were free of cataract at baseline from the UK Biobank. Frequency and type of F&V intake were assessed using a web-based 24-h dietary questionnaire from 2009 to 2012. Development of cataract during the follow-up was defined by self-report or hospital inpatient records up to 2021. Cox proportional regression models were used to estimate the association between F&V intake and incident cataract.
Results: During a mean follow-up of 9.1 years, 5753 participants developed cataract with a corresponding incidence of 8.0%. After adjusting for multiple demographic, medical and lifestyle covariates, higher intake of F&V were associated with a lower risk of cataract (≥6.5 vs. <2 servings/week: hazards ratio [HR]: 0.82, 95% CI: 0.76 to 0.89; P < 0.0001). Regarding specific types, significant reduced risk of cataract was found for higher intake of legumes (P = 0.0016), tomatoes (≥5.2 vs. <1.8 servings/week: HR: 0.94, 95% CI: 0.88 to 1.00), and apple and pear (>7 vs. <3.5 servings/week: 0.89, 95% CI: 0.83 to 0.94; P < 0.0001), but not for cruciferous vegetables, green leafy vegetables, berry, citrus fruit or melon. Smokers were found to benefit more from F&V intake than former and never smokers. Men also could benefit more from higher vegetable intake than women.
Conclusions: More F&V intake, especially legumes, tomatoes, apple and pear was associated with lower risk of cataract in this UK Biobank cohort.
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export
Authors: Yu Xiaopeng , Tong Huanjun , Chen Jialu , Tang Chenwei , Wang Shuqing , Si Yu , Wang Shouhua , Tang Zhaohui 
Published: September 2022

Abstract
The carcinogenic role of FASN by regulating lipid metabolism reprogramming has been well established in multiple tumors. However, whether mechanisms during intrahepatic cholangiocarcinoma (ICC) progression such as circRNAs regulate FASN expression remains unknown. Here we demonstrate a lipid metabolism related circRNA, circMBOAT2 (has_circ_0007334 in circBase), frequently upregulated in ICC tissues, and positively correlated with ICC malignant features. Knockdown circMBOAT2 inhibits growth and metastasis of ICC cells. Mechanistically, circMBOAT2 combines with PTBP1 and protect PTBP1 from ubiquitin/proteasome-dependent degradation, impairing the function of PTBP1 to transfer FASN mRNA from the nucleus to the cytoplasm. Moreover, circMBOAT2 and FASN have the same effect on fatty acid profile, unsaturated fatty acids instead of saturated fatty acids are primarily regulated and associated with malignant behaviors of ICC cells. The levels of lipid peroxidation and ROS were significantly higher when FASN was knocked down and recovered when circMBOAT2 was overexpressed. Our results identified that circMBOAT2 was upregulated in ICC and promoted progression by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export, which altered lipid metabolic profile and regulated redox homeostasis in ICC, suggesting that circMBOAT2 may serve as an available therapeutic target for ICC with active lipid metabolism.
Strong extended SWIR cavity resonances in a single GeSn nanowire
Authors: Kim Youngmin , Assali Simone , Joo Hyo-Jun , Koelling Sebastian , Chen Melvina , Luo Lu , Shi Xuncheng , Burt Daniel , Ikonic Zoran , Nam Donguk , Moutanabbir Oussama 
Published: September 2022

Abstract
Nanowires are promising platforms for realizing ultra-compact light sources for photonic integrated circuits. In contrast to impressive progress on light confinement and stimulated emission in III-V and II-VI semiconductor nanowires, there has been no experimental demonstration showing the potential to achieve strong cavity effects in a bottom-up grown single group-IV nanowire, which is a prerequisite for realizing silicon-compatible infrared nanolasers. Herein, we address this limitation and present the first experimental observation of cavity-enhanced strong photoluminescence from a single Ge/GeSn core/shell nanowire. A sufficiently large Sn content (~ 10 at%) in the GeSn shell leads to a direct bandgap gain medium, allowing a strong reduction in a material loss upon optical pumping. Efficient optical confinement in a single nanowire enables many round trips of emitted photons between two facets of a nanowire, achieving a narrow width of 3.3 nm. Our demonstration opens new possibilities for ultrasmall on-chip light sources towards realizing photonic-integrated circuits in the underexplored range of extended SWIR.
A combined bioinformatics and experimental approach identifies RMI2 as a Wnt/β-catenin signaling target gene related to hepatocellular carcinoma
Authors: Tsai Hung-Wen , Cheng Shu-Wen , Chen Chou-Cheng , Chen I-Wen , Ho Chung-Liang 
Published: September 2022

Abstract
Background: The Wnt/β-catenin signaling pathway plays an important role in embryogenesis and tumorigenesis. In human cancer, abnormal activity of Wnt/β-catenin signaling pathway induces overexpressed of downstream genes, and initiate oncogene. There are several target genes known to be key players in tumorigenesis, such as c-myc, cyclin D1, MMPs or survivin. Therefore, identifying the target genes of Wnt/β-catenin signaling pathway is important to understanding Wnt/β-catenin-mediated carcinogenesis. In this study, we developed a combined bioinformatics and experimental approach to find potential target genes.
Methods: Luciferase reporter assay was used to analyze the promoter activity of RMI2. WST1 cell proliferation assays and transwell assays were performed to determine the proliferation and migration capacities of RMI2 overexpressing or knockdown stable hepatic cells. Finally, xenograft experiments were performed to measure the tumor formation capacity in vivo.
Results: The results showed that RMI2 mRNA was upregulated after LiCl treatment and Wnt3a-conditioned mediumin a culture of SK-hep-1 cell lines. A chromatin immunoprecipitation (ChIP) assay showed that the β-catenin/T cell-specific factor (TCF) complex binds to the putative TCF binding site of the RMI2 promoter. We then found a TCF binding site at –333/–326 of the RMI2 promoter, which is crucial for β-catenin responsiveness in liver cell lines. RMI2was overexpressed in hepatoma tissue and cell lines, and it promoted the migration and invasion of HCC cells. Moreover, RMI2 upregulated the expression of epithelial-mesenchymal transition (EMT) markers and the Wnt3a/β-catenin-related genes, but silencing RMI2 had the opposite effects. Notably, the expression of RMI2 was positively correlated with the clinical data of HCC patients who had significantly shorter overall survival (OS) and disease-free survival (DFS) (Both : P < 0.05). In addition, a total of 373 HCC patients’ data from the Caner Genome Atlas project (TCGA) were used to validate our findings.
Conclusions: Taking all these findings together, we determined that RMI2 was a new target gene of the Wnt/β-catenin signaling pathway.We also found that RMI2 promotes EMT markers, HCC cell invasion, and metastasis, which indicated that RMI2 is a potential target for preventing or at least mitigating the progression of HCC.