bluuebunny/crossref_metadata_2025_split huggingface dataset:
High expression of TMEM244 is associated with poor overall survival of patients with T-cell lymphoma
Authors: Chen Cunte , Chen Shaohua , Luo Gengxin , Wang Liang , Zeng Chengwu , Przybylski Grzegorz K. , Li Yangqiu 
Published: July 2022

AbstractT-cell lymphoma (TCL) is an aggressive and genetically heterogeneous malignancy with adverse clinical outcomes; thus, it is worth exploring biomarkers for risk stratification. Previous studies have demonstrated that transmembrane protein 244 gene (TMEM244) is ectopically expressed in Sézary syndrome (SS). In this study, the expression level of TMEM244 and its prognostic value for TCL patients was explored by analyzing RNA-seq data of two large datasets (GSE132550 and GSE113113) containing 129 TCL patients and 13 healthy individuals (HIs) from the Gene Expression Omnibus (GEO) database, the PRJCA002270 dataset containing 124 patients with T-cell acute lymphoblastic leukemia (T-ALL) from the BioProject database, and peripheral blood (PB) samples of 24 TCL and 29 T-ALL patients, as well as 11 normal CD3 + T-cells from our clinical center (JNU). The results suggested that TMEM244 was significantly up-regulated in TCL patients compared with normal CD3 + T-cells or T-ALL in the JNU, GSE132550 and GSE113113 datasets (P < 0.05). However, TMEM244 shows no expression in patients with T-ALL in the JNU-T-ALL and PRJCA002270 datasets. The receiver operating characteristic (ROC) curve analysis indicated that TMEM244 expression had a very high accuracy in diagnosing TCL compared with T-ALL (area under the curve (AUC): 99.4%; P < 0.001). Importantly, high TMEM244 expression was significantly associated with poor OS and shorter 5-year restricted mean survival time (RMST) in TCL patients, especially those treated with chemotherapy. In summary, TMEM244 is also expressed in other types of TCL besides SS, but not in T-ALL. High TMEM244 expression is associated with poor OS in TCL patients, which might be a novel biomarker for prognostic stratification in TCL patients and facilitate the design of novel therapies.
ZG16 promotes T-cell mediated immunity through direct binding to PD-L1 in colon cancer
Authors: Meng Hui , Yao Wu , Yin Yuhui , Li Yizhen , Ding Yi , Wang Liang , Zhang Mingzhi 
Published: July 2022

AbstractImmunotherapy using programmed cell death 1 (PD1) inhibitors has shown great efficacy in colorectal cancer patients harboring mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H) alterations. We previously showed a negative correlation of zymogen granule protein 16 (ZG16) with programmed death-ligand 1 (PD-L1) expression in patients with colorectal cancer. However, how ZG16 regulates PD-L1 expression is unclear. In this study, we showed that ZG16 can directly bind to glycosylated PD-L1 through its lectin domain, leading to PD-L1 degradation. Mutations on the lectin domain of ZG16 largely inhibit the interaction between ZG16 and PD-L1. Importantly, ZG16 overexpression suppressed tumor growth in two syngeneic mouse models through blockage of PD-L1 expression in cancer cells meanwhile suppression of PD1 expression in T cells. We also showed that ZG16 could improve the effect of chemotherapy and may be delivered as a protein to serve as an immune checkpoint inhibitor to promote T-cell mediated immunity.
Real-time event detection in social media streams through semantic analysis of noisy terms
Authors: Kolajo Taiwo , Daramola Olawande , Adebiyi Ayodele A. 
Published: July 2022

AbstractInteractions via social media platforms have made it possible for anyone, irrespective of physical location, to gain access to quick information on events taking place all over the globe. However, the semantic processing of social media data is complicated due to challenges such as language complexity, unstructured data, and ambiguity. In this paper, we proposed the Social Media Analysis Framework for Event Detection (SMAFED). SMAFED aims to facilitate improved semantic analysis of noisy terms in social media streams, improved representation/embedding of social media stream content, and improved summarization of event clusters in social media streams. For this, we employed key concepts such as integrated knowledge base, resolving ambiguity, semantic representation of social media streams, and Semantic Histogram-based Incremental Clustering based on semantic relatedness. Two evaluation experiments were conducted to validate the approach. First, we evaluated the impact of the data enrichment layer of SMAFED. We found that SMAFED outperformed other pre-processing frameworks with a lower loss function of 0.15 on the first dataset and 0.05 on the second dataset. Second, we determined the accuracy of SMAFED at detecting events from social media streams. The result of this second experiment showed that SMAFED outperformed existing event detection approaches with better Precision (0.922), Recall (0.793), and F-Measure (0.853) metric scores. The findings of the study present SMAFED as a more efficient approach to event detection in social media.
Cold ironing: modelling the interdependence of terminals and vessels in their choice of suitable systems
Authors: Pruyn Jeroen , Willeijns Jelle 
Published: July 2022

AbstractCold ironing has the potential to reduce the impact of ship exhausts in densely populated areas. However, especially for tankers, the implementation of this concept is almost non-existent. Still, these vessels have a relatively high port energy use, despite relatively short port visits, as they provide power to both pumps and inert gas systems during unloading and loading. A key factor in the reluctance, besides the fact that a sparkless connection is required, is the lack of a standard and the uncertainty from both tanker owners visiting a berth and terminal owners on which shore power systems to apply. This paper investigates the interdependency between ship and terminal owner choices for systems and establishes the overall most economical solution. Cold ironing was reviewed to identify existing systems and solutions and analyse the tanker fleet and terminals. The insights were combined in an integrated economic model consisting of two sub-models; one relating terminal decisions to a cold ironing price and one establishing the vessel side costs and savings. By using fuel price as an input and acceptance rates (for both terminals and vessels) for cold ironing systems as key variables to determine. The models have been used to identify the potential of cold ironing for shortsea and parcel tankers against different fuel prices and % of fleet and terminals that have shore power equipment. In all cases, shore power was not economical, which was caused by the high costs of the fixed costs of electricity, due to the high powers required. Interesting avenues for further research would be to increase the individuality of the model using e.g. an agent based model. Also extending the model with a battery pack on the terminal to allow for peak-shaving could lead to much lower costs and higher economic potential.
Light and electron microscopic morphology of the fertilized egg and fertilized egg envelope of Poropanchax normani, Poeciliidae, Teleostei
Authors: Kim Dong Heui 
Published: July 2022

AbstractWe examined the morphology of the fertilized egg and the fine structure of fertilized egg envelopes of Poropanchax normani belonging to the family Poeciliidae, also known as Norman’s lampeye using light and electron microscopes. The fertilized eggs with narrow perivitelline space were found to be spherical and demersal, additionally containing small oil droplets in the vitelline membrane. Further, a bundle of adhesive filaments was observed to be present on one side of the fertilized egg. These filaments possessed remarkably high elasticity and were approximately 1-3 mm in length. The size of the fertilized egg was determined to be about 1.49 ± 0.07 mm (n = 30). The outer surface appeared smooth, and adhesive filaments originating at different location of the surface of the envelope were found to be distributed around the egg envelope and were joined together to form a single long bundle in scanning electron microscopic observation. A peak-like structure formed of several straight wrinkles was observed around the micropyle. However, the complete structure of the micropyle could not be studied due to the depth at which it was located. Additionally, the total thickness of the egg envelope was ascertained to be approximately12.5–14.5 μm. The egg envelope consisted of two distinct layers, an outer electron dense layer and an inner lamellar layer, further consisting of 10 sublayers of varying thicknesses. Collectively, it was observed that the morphological characteristics of the fertilized egg, fine structures surrounding the micropyle, outer surface, adhesive structure consisting adhesive filaments, and sections of fertilized egg envelope displayed species specificity.
Treatment-naïve idiopathic inflammatory myopathy: disease evaluation by fluorodeoxyglucose versus pyrophosphate
Authors: Simonsen Jane A. , Thøgersen Karin F. , Hvidsten Svend , Gerke Oke , Høilund-Carlsen Poul F. , Diederichsen Louise P. 
Published: July 2022

Abstract
Background
Imaging of idiopathic inflammatory myopathies (IIMs) is challenging, and no pathognomonic signs exist. Different tracers have been tested for this purpose, mainly inflammation markers including technetium-99m-pyrophosphate (PYP). We aimed to examine the utility of fluorine-18-fluorodeoxyglucose (FDG) relative to PYP in idiopathic inflammatory myopathy (IIM).

Methods
Using visual grading and CT-guided muscular segmentation and standardized uptake values (SUVs), we assessed muscular tracer uptake qualitatively and quantitatively, comparing FDG uptake in eight patients with recent-onset IIM and 24 healthy control persons and FDG and PYP uptake in seven patients.

Results
Muscular FDG and PYP uptake was increased in all patients. However, uptake distribution and signal intensity differed considerably. FDG scans revealed clear involvement of certain muscle groups including core and swallowing muscles and, in addition, abnormality in diseased extra-muscular organs. PYP was mainly visible in bones, whereas muscular PYP uptake was generally discrete and primarily located in the extremities. Quantitatively, FDG uptake was significantly higher in patients than in controls; the volume-weighted SUVmean for all right-side muscles was 0.84 versus 0.60 g/ml (95% confidence interval (CI) for mean difference 0.14–0.34, p = 0.0001). FDG SUVmean values were up to four times higher than PYP mean values in upper limb muscles (95% CI for the mean ratio 2.37–3.77, p = 0.0004) and two–three times higher in lower limb muscles (95% CI for the mean ratio 2.28–2.71, p < 0.0001).

Conclusions
Muscular FDG uptake was higher in treatment-naïve IIM patients than in healthy controls and more distinct than PYP uptake in patients with a potential to reveal extra-muscular IIM involvement and malignancy. Thus, FDG appears to be superior to PYP in the diagnostic evaluation of IIM.
Supportive Oncology Care at Home Intervention for Patients With Pancreatic Cancer
Authors: Nipp Ryan D. , Gaufberg Eva , Vyas Charu , Azoba Chinenye , Qian Carolyn L. , Jaggers Jordon , Weekes Colin D. , Allen Jill N. , Roeland Eric J. , Parikh Aparna R. , Miller Laurie , Wo Jennifer Y. , Smith Melissa Hennessey , Brown Patricia M.C. , Shulman Eliza , Fernandez-del Castillo Carlos , Kimmelman Alec C. , Ting David , Hong Theodore S. , Greer Joseph A. , Ryan David P. , Temel Jennifer S. , El-Jawahri Areej 
Published: July 2022

PURPOSE: We sought to determine the feasibility of delivering a Supportive Oncology Care at Home intervention among patients with pancreatic cancer. METHODS: We prospectively enrolled patients with pancreatic cancer from a parent trial of neoadjuvant fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX). The intervention entailed (1) remote monitoring of patient-reported symptoms, vital signs, and body weight; (2) a hospital-at-home care model; and (3) structured communication with the oncology team. We defined the intervention as feasible if ≥ 60% of patients enrolled in the study and ≥ 60% completed the daily assessments within the first 2-weeks of enrollment. We determined rates of treatment delays, urgent clinic visits, emergency department visits, and hospitalizations among those who did (n = 20) and did not (n = 24) receive Supportive Oncology Care at Home from the parent trial. RESULTS: From January 2019 to September 2020, we enrolled 80.8% (21/26) of potentially eligible patients. One patient became ineligible following consent because of moving out of state, resulting in 20 participants (median age = 67 years). In the first 2 weeks of enrollment, 65.0% of participants completed all daily assessments. Overall, patients reported 96.1% of daily symptoms, 96.1% of daily vital signs, and 92.5% of weekly body weights. Patients receiving the intervention had lower rates of treatment delays (55.0% v 75.0%), urgent clinic visits (10.0% v 25.0%), and emergency department visits/hospitalizations (45.0% v 62.5%) compared with those not receiving the intervention from the same parent trial. CONCLUSION: Findings demonstrate the feasibility and acceptability of a Supportive Oncology Care at Home intervention. Future work will investigate the efficacy of this intervention for decreasing health care use and improving patient outcomes.
Silk Vista Baby for the Treatment of Complex Posterior Inferior Cerebellar Artery Aneurysms
Authors: Benalia Victor H. C. , Cortez Gustavo M. , Brasiliense Leonardo B. C. , Starke Robert M. , Killer-Oberpfalzer Monika , Lopes Demetrius K. , Kan Peter T. , Nogueira Raul G. , Johnson Jeremiah N. , Pereira Vitor M. , Kilburg Craig , Khalili Susan , Hanel Ricardo A. 
Published: July 2022

BACKGROUND:
Treatment of small-caliber vessel lesions using flow diverters remains challenging because of vasculature's narrow luminal diameter and tortuosity. This in turn makes navigation and delivery of conventional devices with standard microcatheters more difficult. The Silk Vista Baby (SVB, Balt) flow diversion device was designed for ease of use in vessels with a smaller diameter, distal lesions, and 0.017″ microcatheter delivery systems.

OBJECTIVE:
To report the outcomes of the SVB device on the treatment of posterior inferior cerebellar artery (PICA) aneurysms.

METHODS:
Databases from different centers were retrospectively reviewed for PICA aneurysms treated with SVB. Demographic information, clinical presentation, radiographic characteristics, procedural complications, and immediate postprocedure outcomes were obtained.

RESULTS:
Fourteen patients harboring 15 true PICA aneurysms were treated between January 2019 and June 2021. Nine were female (n = 9/14; 64.2%), and the mean age was 51 ± 14.9 years. Most patients had previously ruptured aneurysms, treated by another endovascular technique. Six aneurysms were located distally (n = 6/15; 40%). The mean neck size was 3 mm (SD 1.35, range 2.5-5 mm), whereas the mean PICA diameter was 1.6 mm (SD 0.26, range 1.5-1.7 mm). The mean length of follow-up was 6 months (SD 8.28, range 4.5-16 months). Treatment-related adverse events included 1 case of transient hypoesthesia. Two additional events were reported, but adjudicated as unrelated to the procedure. Complete occlusion, measured as Raymond-Roy class I, was achieved in all cases.

CONCLUSION:
The SVB device was safely and effectively used in the treatment of PICA aneurysms. The smaller delivery system profile reduces the risk of procedure complications and creates new treatment options for distal lesions.
Charge Transfer between Fe and Ti Induced by Ln Substitution and Temperature in the B-Site-Disordered Perovskites Ln2(FeTi)O6 (Ln = La, Pr, and Nd)
Authors: Goto Masato , Okazaki Masato , Shimakawa Yuichi 
Published: July 2022

Abstract
Newly synthesized B-site-disordered perovskites Ln2(FeTi)O6 (Ln = Pr and Nd) were found to show charge transfer between Fe and Ti ions, which was in contrast to the robust Fe3+/Ti3+ state in the isostructural Ln = La compound La2(Fe3+Ti3+)O6. The charge distribution for Ln = Pr and Nd can be expressed as Ln2(Fe3+0.8Ti3+0.8Fe2+0.2Ti4+0.2)O6 at room temperature, and the amount of Fe2+/Ti4+ increases with decreasing temperature. In addition, the charge transfer resulting in Ln-dependent valence states at the B site strongly affects magnetic properties, including the magnetic transition temperatures and the ground states.
Emergency contraception from historical myth to modern reality: a historical timeline and updated interpretation
Authors: GOLDSTUCK Norman D 
Published: July 2022

Introduction: Emergency contraception is the use of a birth control method after coitus has taken place and there is a fear that it may lead to a pregnancy. Historical attempts were more likely to be harmful rather than effective. Oral estrogens, progestins, anti-progesterone, and partial agonist/antagonists of progesterone have all been used with varying degrees of efficacy. Currently ethinyl estradiol/levonorgestrel combinations, levonorgestrel alone, ulipristal acetate, and mifepristone are the usual oral methods depending on availability. Copper carrying and more recently levonorgestrel releasing intrauterine devices have also been used successfully. The intrauterine devices appear to be more effective than the oral methods and are also regular contraceptive methods and in addition have therapeutic properties. Background: The evolution from longer duration oral treatments with side effects to the current single tablet of levonorgestrel, ulipristal acetate, or mifepristone with low side effects and reasonable efficacy is described. The role of the highly effective copper intrauterine device and now also the levonorgestrel intrauterine device for emergency contraception is examined. Conclusion: Oral emergency contraception is a short term solution. Expanding emergency contraception to include the levonorgestrel releasing intrauterine device may provide long term contraception and health benefits as well as providing emergency contraception.
Case Report: Synchronous bilateral lipoma arborescens of the bicipitoradial bursa
Authors: Elafram Rafik , Ben Romdhane Majdi , Khessairi Nayssem , Hamdi Ahmed 
Published: July 2022

Background: Lipoma arborescens (LA) is an infrequent benign tumor made of mature sub-synovial fatty cell proliferation that may arise into the synovial joint, the bursae or the tendon sheaths. This condition affects mainly the knee joint, but the bicipitoradial bursa is an exceptional location. We report herein a case of a synchronous bilateral (LA) of the bicipitoradial bursa. Case presentation: A 52-year-old patient, with no medical history, presented with a swelling of both front arms that had been progressing for nine years. Physical examination showed a mass in the antecubital fossae of 3cm on the left side and 0.5cm on the right side. Both masses were tender, well-defined, fixed, without inflammatory signs and painful on elbow flexion. A magnetic resonance imaging (MRI) scan was performed, revealing the presence of a septate soft-tissue mass of the distal portion of the brachial muscle of 70x46x27mm. This mass had a heterogeneous fat signal in its depth and a homogeneous fat composition on the outside. The diagnosis of liposarcoma was suspected. The patient underwent surgery to remove both masses. Gross examination showed a characteristic frond-like or digitiform pattern. Microscopical examination demonstrated papillary proliferation of the synovial villi. The final diagnosis was of LA. The patient had no complications and there was no recurrence of LA. Conclusions: LA is a rare condition, and the bicipitoradial bursa is an exceptional location. Histological confirmation is mandatory to correct the diagnosis.
Understanding the stress and coping experiences of undergraduate university students in the COVID-19 context: A qualitative study
Authors: Trower Rebecca , Hurley Laoise , Murphy Emer R. , Durand Hannah , Farrell Karen , Meade Oonagh , Molloy Gerard J. , McSharry Jenny 
Published: July 2022

Background: The various psychological challenges experienced by university students have been well- characterised. The university experience can be stressful, which can negatively impact on mental health. Student stress was further exacerbated by the COVID-19 pandemic due to the lack of on-campus learning and peer contact. This study aims to understand the stress experiences and coping strategies of undergraduate university students in Ireland during the COVID-19 pandemic and to explore the differences between first-year and returning students’ experiences. Methods: Undergraduate students at the National University of Ireland, Galway, took part in online semi-structured interviews via Microsoft Teams. Interviews were recorded, transcribed verbatim, and analysed using inductive reflexive thematic analysis. Results: Nineteen students were interviewed (10 first-years and 9 returning students). Three themes were developed in relation to perceived stressors: (1) ‘The unknown. The dragon. The fear of getting sick’ with sub-themes, ‘Fear of COVID-19’ and ‘Chronic uncertainty and negative media messages’; (2) ‘Online learning is overwhelming’ with sub-themes ‘Difficulties with university workload’ and ‘One place, same screen, same things’; (3) ‘Social isolation’ with sub-themes ‘Lack of peer contact’ and ‘Fear of missing out’. Two themes in relation to coping were also developed: (1) ‘Help each other, keep each other afloat’ and (2) ‘Focusing on the positives in a shared storm.’ First-year students described additional stressors not experienced by returning students such as navigating university for the first time remotely and making friends virtually. Conclusion: All students struggled with various additional stressors due to the COVID-19 situation, particularly first-year students who experienced additional stressors while adjusting to university in a pandemic context. All students described coping strategies to help manage stress, which may be useful in developing future interventions and mental health supports for university students.