bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Influence Factors and Mechanism of Chromium Removal by Sulfide Nano-zero Valent Iron
Authors: Li Yajun , Zhang Yongxiang , Lin Yuhui , Yang Wenjing , Du Wei , Zhao Chonghui 
Published: April 2022

Abstract
In this study, two-step methods were used to prepare sulfide nano-zero valent iron and the morphology, elemental composition, surface charge, crystal structure and elemental valence were characterised. The influence factors (S/Fe ratio, initial pH and initial concentration of Cr(VI)) and the mechanism of Cr(VI) removal was determined. The results revealed that the sulphide modification could increase the removal rate of chromium. The maximum removal rate of chromium was 81 mg/g, achieved at an S/Fe ratio of 0.1. The Cr(VI) removal process by S-nZVI0.1 is a multistep process, starting with strong adsorption to the surface of the particles by adsorption, followed by reduction of Cr(VI) to Cr(III), and finally fixing the contaminants on the S-nZVI0.1 surface by co-precipitation. This study has great significance for preparing a remediation material that could be efficiently used for repairing of Cr(VI) contaminated sites.
Associations between urine cobalt and prevalence of kidney stones in American s aged ≥ 20 years old
Authors: Wang Jia , Xiao Yunfei , Yin Shan , Bai Yunjin , Wang Jiahao , Cui Jianwei 
Published: April 2022

Abstract
To determine whether urine cobalt is associated with the prevalence of kidney stones. We conducted a cross-sectional study of participants (≥ 20 years) involved in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018. Urine cobalt level was divided into four groups: 0.02–0.22, 0.22–0.36, 0.36–0.58 and 0.58–37.40 ug/L. The independent correlation between urine cobalt and prevalence of kidney stones was determined by logistic regression analyses. Totally 10,744 participants aged over 20 years without pregnancy were eligible. Among them, 1,041 participants reported as ever having developed kidney stones. Patients with kidney stones developed significantly higher urine cobalt than the non-stone participants. The kidney stone patients were more likely to have smoking ≥ 100 cigarettes in life, hypertension, diabetes, cancer, and heavy activity. Multivariate logistic regression indicated a significantly positive relationship between urine cobalt level and occurrence of kidney stones (OR 1.059, 95%CI 1.018–1.102). Moreover, the outcome remained unchanged after some sophisticated factors were adjusted (OR 1.048, 95%CI 1.005–1.093), and the incidence of kidney stones rose with the increasing urine cobalt level [OR (95%CI) = 0.22–0.36 ug/L: 1.166 (0.955–1.422); 0.36–0.58 ug/L: 1.348 (1.108–1.640); 0.58–37.40 ug/L: 1.683 (1.382–2.044)]. Higher urine cobalt concentration is significantly related to an increased risk of kidney stones. However, more high-quality prospective studies are needed to elucidate the causal correlation between cobalt level and kidney stones.
Assessment of nutritive compositions of a novel wrinkled-leaf sesame mutant JQA: A new leafy vegetable suitable for eating
Authors: Liu Hongyan , Zhou Fang , Zhou Ting , Yang Yuanxiao , Zhao Yingzhong 
Published: April 2022

Abstract
Sesame leaves represent a new edible vegetable. However, data regarding the nutritional composition of the leaves, especially their phytonutrient composition, are scarce. In this study, the nutrient content of a new wrinkled-leaf sesame mutant JQA were determined. Chromatographic techniques with UV-Vis and mass detection were used to analyze the vitamin and flavonoid components. Inductively coupled plasma-atomic emission spectrometry was used to characterize the mineral content of the leaves, and standard techniques were used to determine the corresponding indicators. We found that sesame leaves had a low crude fat (5.33%), saturated acid (24.772%), unsaturated acid (32.012%), and crude fiber (36.16%) content, and a high content of water (86.50%), total flavones (65.672 mg/g), K (16.118 mg/g), vitamin C (1.695 mg/g), vitamin A (0.97 mg/g), vitamin D (1.33 mg/g), and vitamin B2 (14.4 mg/g). The sesame leaves were high in vitamins, calcium, and potassium compared to other common green leafy vegetables. The fresh leaves had a mean total flavone content of 65.672 mg/g, mainly composed of glycosylated quercetin and kaempferol derivatives. Sesame leaves can be eaten fresh or can be preserved in a dry state for more than one year. The nutritional composition was generally stable during storage. These results suggested that the wrinkled sesame leaves are a rich source of nutrients and therefore have potential use as an edible vegetable.
Investigation of dirigent like domains from bacterial genomes
Authors: Bardin Merlin , Rousselot-Pailley Pierre , Tron Thierry , Robert Viviane 
Published: April 2022

Abstract
BACKGROUND: Dirigent proteins (DIRs) have been named after plant proteins capable to direct the stereoselectivity in the coupling of radicals from various metabolites. Recently, evidence that DIR proteins occurred far more abundantly than previously thought (i.e., beyond plant kingdom) have been obtained.RESULTS: Analyzes of structural and functional genomic data led to the identification of the Pfam PF03018 domain as characteristic of DIR proteins. This domain has been further identified in the sequence of bacterial proteins therefore named as DIR-like (DIRL). The objective of this study was to perform a thorough bioinformatic analysis on these DIRLs to highlight any information leading to the selection of candidate bacteria for further cloning, purification, and characterization of bacterial DIRs. CONCLUSIONS: From studies of primary structures, predictions of their secondary and tertiary structures, prediction of DIRL signals sequences, analysis of their gene organization and potential regulation, a list of primary bacterial candidates is proposed.
Systematic treatment of giant gastroduodenal anastomotic leakage: a case report
Authors: Yang Rui , Wang Yinchun , Yang Yuyi , Yang Qingqiang 
Published: April 2022

Abstract
Background: Gastroduodenal anastomotic leakage is one of the most dreadful complications of gastrectomy and poses a great threat for treatment. However, there has been no effective treatment for it up to now. We report a case, a patient with huge gastroduodenal anastomotic leakage, was eventually recovered after conservative treatment up front and later resolution of anastomotic obstruction through gastrojejunostomy and jejunostomy.Methods and results: A 50-year-old man underwent a distal gastrectomy for a giant penetrating ulcer in the lesser curvature of the gastric sinus. Digestive reconstruction was completed by the Billroth I method. But an anastomotic leakage occurred on postoperative day 9 and a high output of duodenal juice was observed, and the following gastroscopy suggested that there was a large breach in the gastroduodenal anastomosis. Because of the patency of the drainage tube and the limitations of the patient's condition, conservative treatment was advocated and a nasojejunal tube was placed under the gastroscope for enteral nutrition. Unexpectedly, during subsequent treatment, persistent hypothermia associated with rheumatoid arthritis, drainage-associated transverse colon leakage and anastomotic stenosis occurred. Eventually, after taking the gastrojejunostomy and jejunostomy and gradually withdrawing and flushing the drainage tube, the patient was able to achieve a tube-free state and eat in the normal way.Conclusion: The course of the patient’s treatment was continuous and systematic. In this case, we found that conservative treatment was feasible for giant gastroduodenal anastomotic leakage in the presence of patent drainage and limited physical signs. And for secondary anastomotic stenosis, gastrojejunostomy can effectively relieve the obstruction.
Understanding the needs and priorities of people living with persistent pain and long-term musculoskeletal conditions during the Covid-19 pandemic.
Authors: Davis Sally Fowler , Humphreys Helen , Maden-Wilkinson Tom , Withers Sarah , Lowe Anna , Copeland Robert J 
Published: April 2022

Abstract
Background: Critiques of public involvement (PI) are associated with failing to be inclusive of under-represented groups and this leads to research that fails to include a diversity of perspectives. Aim: The aim of this PI project was to understand the experiences and priorities of people from three seldom heard groups whose musculoskeletal pain may have been exacerbated or treatment delayed due to COVID-19. Engaging representatives to report diverse experiences was important, given the goal of developing further research into personalised and integrated care and addressing population health concerns about access and self-management for people with musculoskeletal pain.Methods: The project was approved via Sheffield Hallam University Ethics but was exempt from further HRA approval. A literature review was conducted followed by informal individual and group discussions involving professionals and people with lived experience of fibromyalgia pain, those waiting for elective surgery and experts associated with the care home sector. Findings from the literature review were combined with the insights from the public involvement. Together, these formed narratives that highlighted the challenges associated with persistent pain and informed the creation of consensus statements on the priorities for service improvement and future research. The consensus statements were shared and refined with input from an expert steering group.Results: The narratives describe pain as a uniformly difficult experience to share with professionals; it is described as exhausting, frustrating, and socially limiting. Pain leads to exclusion from routine daily activities and often resigns people to feeling and being unwell. In all cases there are concerns about accessing and improving services and critical issues associated with optimising physical activity, functional wellbeing and managing polypharmacy. Exercise and/or mobilisation are important and commonly used self-management strategies but opportunity and advice about safe methods are variable. Services should focus on personalised care including self-management support and medication management so that people’s views and needs are heard and validated by health professionals. Conclusions: More research is needed to prioritise the most effective pain management strategies and public involvement is important to shape the most relevant research questions. Health and care systems evaluation is needed to address the scale of the population health need. The pandemic appears to have highlighted pre-existing shortcomings in holistic pain management.
Atrial approach in mitral valve surgery: A propensity analysis of differences in the incidence of clinically relevant adverse effects
Authors: Obando Carlos E , Garzón Javier , Ramirez Lina , Castillo Andrea , Guerrero Albert , Chalela Tomas , Sandoval Diana C , Giraldo-Grueso Manuel , Sandoval Nestor F , Camacho Jaime , Umaña Juan Pablo 
Published: April 2022

Abstract
Background: The lack of evidence on postoperative outcomes using mitral valve approaches leaves the choice to the surgeon’s preference, based on individual experience, speed, ease, and quality of exposure.Methods: The present study analysed patients undergoing mitral valve surgery using a superior transseptal approach or a left-atrial approach between 2006 and 2018. We included first-time elective mitral valve procedures, isolated, or combined, without a history of rhythm disturbances. We used propensity score matching based on 26 perioperative variables. The primary endpoint was the association between the superior transeptal approach and clinically significant adverse outcomes, including arrhythmias, need for a permanent pacemaker, cerebrovascular events, and mortality.Results: A total of 652 patients met the inclusion criteria; 391 received the left atrial approach, and 261 received the superior transseptal approach. After matching, 96 patients were compared with 69 patients, respectively. The distribution of the preoperative and perioperative variables was similar. There was no difference in the incidence of supraventricular tachyarrhythmias. The incidence of nodal rhythm (p= 0.008) and length of stay in intensive care (p= 0.04) were higher in the superior transseptal group, but the need for permanent pacemaker implantation was the same. Likewise, there was no difference in the need for anticoagulation due to arrhythmia, the incidence of cerebrovascular events or mortality in the postoperative period or in the long-term follow-up.Conclusion: We did not find an association with permanent heart rhythm disorders or any other significant adverse clinical outcome. Therefore, the superior transeptal approach is useful and safe for mitral valve exposure.
Genome-wide Association Study of Thoracic Aortic Aneurysm and Dissection in the Million Veteran Program
Authors: Klarin Derek , Devineni Poornima , Sendamarai Anoop , Angueira Anthony , Graham Sarah , Shen Ying , Levin Michael , Pirruccello James , Surakka Ida , Karnam Purushotham , Roychowdhury Tanmoy , Li Yanming , Wang Minxian , Aragam Krishna , Paruchuri Kaavya , Shakt Gabrielle , Tsao Noah , Judy Renae , Vy Ha My , Verma Shefali , Rader Daniel , Do Ron , Bavaria Joseph , Nadkarni Girish , Ritchie Marylyn , Guo Dongchuan , Ellinor Patrick , LeMaire Scott , Milewicz Dianna , Willer Cristen , Natarajan Pradeep , Tsao Phil , Pyarajan Saiju , Damrauer Scott 
Published: April 2022

Abstract
Current understanding of the genetic contribution to thoracic aortic aneurysms and dissections (TAAD) has largely been informed through studies focusing on rare, Mendelian forms of disease. In the current analysis we performed the largest genome-wide association study (GWAS) of TAAD to date, testing ~25 million DNA sequence variants in 8,626 participants with (7,050 European, 1,266 African, and 310 Hispanic ancestry individuals) and 453,043 participants without TAAD in the Million Veteran Program. The results were replicated in an independent sample of 4,459 individuals with and 512,463 without TAAD from 6 cohorts. We identified 21 TAAD loci, 17 of which have not been previously reported. We leverage phenome-wide scanning and causal inference methods to provide evidence that TAAD is a non-atherosclerotic aortic disorder distinct form other forms of vascular disease; we subsequently use Bayesian techniques and single cell/nucleus RNA sequencing data to identify causal risk genes and cell types. Finally, we generate a TAAD polygenic risk score and demonstrate that those at the top 5% of polygenic risk are over 4-fold more likely to experience an incident, fatal TAAD event. Our results demonstrate that the genetic architecture of TAAD mirrors that of other complex traits and is not solely inherited through protein altering variants of large effect size. These data provide new mechanistic insights into TAAD risk and improve our understanding of thoracic aortic disease.
The nurse: relationship between leadership style, values and Quality of Work Life
Authors: Rached Chennyfer Dobbins Abi , Sousa Gabriella de Castro , Borges Flávio Adriano , Carloni Pablo Ramon Rodrigues Freitas Ramos , Domercant Herline , Siqueira Bianca Batista 
Published: April 2022

Abstract
Background: Leadership has been widely studied over the years due to its importance to organizations. The leader must be able to direct their team to reach the objectives and goals established in the organization, creating a work environment capable of providing this. Value-oriented leaders, teams, organizations, and communities are the most successful when they are able to engage workers in such a way that there are gains in retention rates and reduced absenteeism. Quality of Work Life is something that goes beyond labour laws. It is a dynamic that involves physical, technological, social, and psychological factors, which change and influence the organizational climate, reflecting on the worker's well-being and, consequently, on their productive capacity. Objective: To analyse the relationship between leadership styles, personal values ​​of nursing leaders and the Quality of Work Life of nurses who attend the Graduate Program in Nursing Management (PPGEn). Methods: This is a quantitative, cross-sectional study. Data were collected using the standardized instrument Quality of Working Life Questionnaire (QWLQ-bref), and an exploratory-descriptive analysis was performed. Results: Of the 123 nurses interviewed, 64.22% rated the Quality of Work Life as satisfactory and 31.7% as very satisfactory. Through these data, the relationship between the task leadership style and professional satisfaction in the nurse's quality of life was perceived. Conclusion: The results do not point to a relationship between the managerial style of the nurse leader and the perception of Quality of Work Life. However, it is noteworthy that the Quality of Work Life describes values ​​that go beyond the human. Conclusion: The results of this study did not indicate a correlation between leadership styles, personal values ​​and the perception of Quality of Work Life, however, conclusions can be made from the highest and lowest scores presented. Everyone in a leadership role should be aware of the values ​​they hold, their strengths, and the areas they can improve as they grow as a leader. The importance of a positive organizational climate so that the established goals are achieved is clear, and, in this sense, valuing the human factor will make the achievement of goals more feasible.
Impact of essential amino acid intake, resistance exercise, and aging on the concentration of Achilles peritendinous amino acids and procollagen I⍺1 in humans
Authors: Campbell Nathan W.C. , Patel Shivam H. , Ferrandi Peter , Couture Samantha , Farino Dominick O. , Stout Julianne , Sabbaghi Arman , Carroll Chad C. 
Published: April 2022

Abstract
Several recent studies have shown that consuming amino acid-rich compounds improves tendon collagen content and biomechanical properties. Yet, it is not clear if the consumption of amino acids alters local (peritendinous) amino acid concentrations. If aging or exercise influence local amino acid concentrations in conjunction with an amino acid bolus is also not known. We conducted two studies. In Study 1, young women (n=7, 25+/-2 yrs.) completed two identical resistance training sessions with either essential amino acid (EAA) or placebo consumption. In Study 2, an EAA bolus identical to Study 1 was given to younger (n=7; 27+/-1 yr.) and older adults (n=6; 68+/-2 yrs.). Microdialysis was used to determine Achilles peritendinous amino acid and pro-collagen I⍺1 (a marker of collagen synthesis) concentrations. In Study 1, amino acid consumption increased peritendinous concentrations of all EAA except histidine (p<0.05). In Study 2, the peritendinous concentration of EAAs except for methionine, histidine, and lysine (p>0.05) increased with time (p<0.05). Further, the concentrations of most measured amino acids were greater in older adults (p<0.05). Pro-collagen I⍺1 concentration (p>0.05) was unaffected by exercise, EAA, or aging (p>0.05). Our findings demonstrate that: 1) when not combined with exercise, an oral EAA bolus leads to only modest increases in Achilles peritendinous amino acid concentrations, 2) when combined with resistance exercise, EAA consumption resulted in greater peritendinous amino acid concentrations compared to no exercise, 3) the basal concentrations of most amino acids were greater in older adults, and 4) neither the EAA bolus nor exercise altered peritendinous pro-collagen concentrations.
Homoharringtonine is Synergistically Lethal with BCL-2 inhibitor APG-2575 in Acute Myeloid Leukemia
Authors: Wei Wenwen , Huang Shujuan , Ling Qing , Mao Shihui , Qian Yu , Ye Wenle , Li Fenglin , Pan Jiajia , Lin Xiangjie , Huang Jiansong , Huang Xin , Sun Jie , Jin Jie 
Published: April 2022

Abstract
Background: Despite advances in targeted agents development, effective treatment of acute myeloid leukemia (AML) remains a major clinical challenge. The BCL-2 inhibitor exhibited well clinical activity in AML treatment, and APG-2575, a novel BCL-2 selective inhibitor, demonstrated anti-tumor activity in hematologic malignancies.Methods: The synergistic effects of APG-2575 and HHT were studied in AML cell lines and primary samples. MTS was used to measure the cell viability. Annexin V/propidium iodide staining was used to measure the apoptosis rate by flow cytometry. We established AML xenograft tumor model to evaluate the anti-leukemic effect of the combination of BCL-2 inhibitor and HHT in vivo. Western blot was used to examine the expression of related proteins level.Results: In this study, we demonstrated that APG-2575, showed comparable anti-leukemic effect to the FDA-approved BCL-2 inhibitor ABT-199, in AML cell lines or primary AML patient samples. However, similar to ABT-199, APG-2575 treated AML cells showed increased MCL-1, which lead to the resistance of AML cells to the BCL-2 inhibitor. Our previous studies found homoharringtonine (HHT) induced AML cells apoptosis by promoting MCL-1 degradation through the PI3K/AKT/GSK3β signaling pathway. Herein, we show that combined treatment of HHT with APG-2575 synergistically inhibited AML cell growth and expedited apoptosis by suppressing MCL-1. In addition, APG-2575 combined with HHT had a strong synergistic anti-tumor effect in AML xenograft mouse model.Conclusion: Overall, our results provide an effective AML treatment strategy through a reasonable combination of APG-2575 and HHT, which is worthy of further clinical research.
Design of User Management and security Tools for Centaurus
Authors: Dubey Shreya Mukesh 
Published: April 2022

Abstract
Centaurus is an open source software that facilitates the effective development of distributed computing applications in 5G cloud environment. This is necessary for efficient application development since Kubernetes is lacking multi-tenant capability and also in the provision of security. In this scenario, Centaurus can be used to build these gaps. In this project work, a new user and security management tool has been developed for Kubernetes platform using Centaurus. The major tools developed in this project work are User management tool using login feature, tool for clustering and role creation, Multi-Tenant Management tool, Namespace management and virtual machine management tool and a role based access control tool for enhancing the security of distributed applications. Moreover, for enhancing the security of applications developed using Centaurus, a new Role Based Access Control tool has been developed in this project work. This Role Based Access Control tool provides facilities for creating roles, assigning privileges, securing applications based on user privileges and finally the facility for revoking the privileges in order to enhance the security of the system. The major advantages of the system developed in this project work include the increase in Usability, flexibility and security of the applications.