bluuebunny/crossref_metadata_2025_split huggingface dataset:
May Measurement Month 2017–2019: an analysis of blood pressure screening results from Dominican Republic
Authors: Valdez-Tiburcio Osiris , Gonzalez-Medina Angel , Valdez-Valoy Laura , Santillan-Pascual Marcos , Baez-Noyer Nelson , Diaz-Montero Belianix , Wang Wei , Beaney Thomas , Poulter Neil R 
Published: October 2022

Abstract
Arterial hypertension is the main risk factor that contributes to cardiovascular disease and represents a leading cause of morbidity and mortality globally. May Measurement Month (MMM) is a global screening campaign with the aim of improving awareness of hypertension at the individual and population level, an initiative that has been supported in the Dominican Republic (DR) since 2017. Adults (≥18 years) were recruited by sampling in different places in the DR, three blood pressure (BP) readings were performed per participant, and data on risk factors and comorbidities were collected. Hypertension was defined as systolic BP ≥140 mm Hg, diastolic BP ≥ 90 mm Hg (mean of second and third readings), and/or taking antihypertensive medication. Multiple imputation was used to estimate participants’ mean BP when three readings were not available. Of 3693 participants, 2134 (57.8%) had hypertension, of whom 1646 (77.1%) were taking medication, but only 38.6% of those on treatment had their BP under control(&lt;140/90 mmHg). The remaining 61.4% of the participants received inadequate treatment. A total of 66% of treated patients were taking a single antihypertensive drug. MMM provides an important platform for the standardized compilation of BP data and the creation of awareness of hypertension in the DR and other nations of the world. The data generated from the 2017–2019 MMM campaigns highlight the importance of adequate detection, knowledge, and control of BP.
Evaluation of functional constipation frequency and related factors
Authors: Cifci Ismail , Gokdemir Ozden , Aygun Olgu , Guldal Dilek 
Published: October 2022

AbstractBackground/IntroductionThe aim of this study is to determine the prevalence of functional constipation (FC) in İzmir using ROME IV criteria, as well as to investigate the relationship of FC with various factors, particularly obsessive–compulsive disorder (OCD) and personality traits.MethodsThis study was designed as cross-sectional analytical research. The participants were those aged 18 and over who applied to Family Health Centers (FHC). Participants were randomly selected from 11 FHC. Data were collected via a face-to-face interview, a questionnaire designed by the researcher using ROME IV criteria, the OCD module in the Mini-International Neuropsychiatric Interview, and the Ten-Item Personality Inventory.ResultsThe study included 990 participants, 502 (50.7%) women and 488 (49.3%) men. According to the ROME IV criteria, 7% (n = 69) of the participants in our study had FC. OCD was found to be present in 13% of the cases. This rate was found to be significantly higher (P = 0.003). The emotional stability scores of FC patients were found to be significantly lower (P = 0.038).ConclusionsFC is a common gastrointestinal system complaint in primary care and emphasizes the importance of the diagnostic approach, particularly in patients presenting with constipation due to treatment differences. Individuals with FC diagnoses had a significantly higher incidence of OCD, and their emotional stability levels were significantly lower. It should be noted that psychiatric diseases and personality traits may also play a role in this situation in individuals diagnosed with FC.
Expression and localization of tubulin isotypes and its mRNAs duringThecaphora freziidevelopments
Authors: Figueroa Ana Cristina , Díaz María Soledad , Alasino Roxana Valeria , Yang Pablo , Soria Néstor Walter , Beltramo Dante Miguel 
Published: October 2022

ABSTRACTThecaphora frezii is a phytopathogenic fungus that infects Arachys hypogaea L. and produces peanut smut. It has three ontological stages teliospores, basidiospores, and hyphae. Microtubules are cellular structures that participate in various important cellular processes. In this work, we analyzed the presence and location of α-tubulin isotypes and enzymes that participate in tyrosination–detyrosination in the three stages of T. frezii. Although both tyrosinated and detyrosinated tubulin seem to be associated with a membrane fraction component that gives it a similar behavior to integral proteins, in the soluble cytosolic fraction, only detyrosinated tubulin was detected, not tyrosinated tubulin. The presence of α-tubulin was not detected using the monoclonal antibody DM1A as neither acetylated tubulin. The RNA-Seq analysis showed the presence of α, β, and γ-tubulins and the genes that codes for tyrosine–tubulin ligase and cytosolic carboxypeptidase 1, enzymes that are involved in post-translational modification processes. These sequences showed a high percentage of identity and homology with Ustilago maydis, Thecaphora thlaspeos, and Anthracocystis flocculosa. This is the first report for tubulins subpopulations and the cellular distribution in T. frezii, which together with the data obtained by RNA-Seq contribute to the knowledge of the pathogen, which will allow the development of control strategies
Turf Wars in Foreign Policy Bureaucracy: Rivalry between the Government and the Bureaucracy in Turkish Foreign Policy
Authors: Gülen Berkay 
Published: October 2022

Abstract
This paper, using examples from Turkish foreign policy between 2002 and 2014, argues that the fragmentation in foreign policymaking due to adopting different foreign policy ideas, that is, ideas of the elected leadership and the bureaucracy, is likely to generate competition between the state agencies that constitute the foreign policy bureaucracy. If there is backlash in the bureaucracy to realize the government's revisionist foreign policy goals, then the government aims to transform the bureaucracy by empowering certain small bureaucratic units, that is, missionary agencies. Once the degree of conflict between the government and the bureaucracy becomes severe, then the elected officials opt to work with the established bureaucratic agencies to speed up the decision-making processes. The analysis based on a series of interviews conducted with sixty-one Turkish foreign policymakers shows that the turf war in the foreign policy bureaucracy is a conceptual framework for comprehending how elected officials use bureaucratic tactics to undermine the involvement of bureaucrats in decision-making processes. Finally, the study contributes to current debates on populism and the presidentialization of foreign policy by showing that the foreign policy bureaucracy is not immune from the anti-elite, anti-establishment rhetoric of governments.
Germline de novo variant F747S extends the phenotypic spectrum ofCACNA1DCa2+ channelopathies
Authors: Török Ferenc , Tezcan Kamer , Filippini Ludovica , Fernández-Quintero Monica L , Zanetti Lucia , Liedl Klaus R , Drexel Raphaela S , Striessnig Jörg , Ortner Nadine J 
Published: October 2022

AbstractGermline gain-of-function missense variants in the pore-forming Cav1.3 α1-subunit (CACNA1D gene) confer high risk for a severe neurodevelopmental disorder with or without endocrine symptoms. Here, we report a 4-week-old new-born with the novel de novo missense variant F747S with a so far not described prominent jittering phenotype in addition to symptoms previously reported for CACNA1D mutations including developmental delay, elevated aldosterone level and transient hypoglycemia. We confirmed the pathogenicity of this variant in whole-cell patch-clamp experiments with wild-type and F747S mutant channels heterologously expressed together with α2δ1 and cytosolic β3 or membrane-bound β2a subunits. Mutation F747S caused the quantitatively largest shift in the voltage dependence of activation (−28 mV) reported so far for CACNA1D germline mutations. It also shifted inactivation to more negative voltages, slowed the time course of current inactivation and slowed current deactivation upon repolarization with both co-expressed β-subunits. In silico modelling and molecular docking, simulations revealed that this gain-of-function phenotype can be explained by formation of a novel inter-domain hydrogen bond between mutant residues S747 (IIS6) with N1145 (IIIS6) stabilizing selectively the activated open channel state. F747S displayed 2–6-fold increased sensitivity for the L-type Ca2+ channel blocker isradipine compared to wild type. Our data confirm the pathogenicity of the F747S variant with very strong gain-of-function gating changes, which may contribute to the novel jittering phenotype. Increased sensitivity for isradipine suggests this drug for potential symptomatic off-label treatment for carriers of this mutation.
Correlation between seabirds and fisheries varies by species at fine-scale pattern
Authors: De la Cruz Andrés , Rodríguez-García Carlos , Cabrera-Castro Remedios , Arroyo Gonzalo M 
Published: October 2022

Abstract
Understanding how fisheries influence seabird distribution is critical in the development of sustainable fisheries management. Species distribution models were applied to analyse the influence of the fishing footprint, discards, and oceanographic factors on seabird attendance patterns to trawlers in the Gulf of Cádiz. More than 30 species of seabirds were attracted to trawlers, although only seven were registered with relatively high frequency and abundance. For these species, fishery footprint was a good predictor for the distribution of four out of seven (yellow-legged gull, lesser black-backed gull, northern gannet, and Cory's shearwater). Yellow-legged and lesser black-backed gull flocked in large numbers to trawlers, mostly in shallow areas where they were also attracted by purse seines. Northern gannets and Cory's shearwaters appeared with relatively high frequency and their distributions correlated with trawler effort and abundance of potential prey discards. Balearic shearwaters were attracted in low numbers and concentrated in shallow areas, where potential prey discards were also more abundant. For these three species, discards as surrogate of natural prey distribution were good predictors of trawler attendance. Our research revealed that, at a local scale, the degree of interaction of seabirds on fishing discards varies by species. Therefore, fine-scale studies are essential in identifying interactions between seabirds and fisheries, and thus assessing conservation issues such as bycatch or the consequences of discard bans.
Genetic analysis of the exploited snow crab (Chionoecetes opilio) in the Barents Sea—possibilities of origin
Authors: Dahle Geir , Sainte-Marie Bernard , Mincks Sarah L , Farestveit Eva , Jørstad Knut E , Hjelset Ann Merete , Agnalt Ann-Lisbeth 
Published: October 2022

AbstractAfter the initial opening of the Bering Strait  5.5–-5.0 My ago, there occurred several periods with exchange of marine species between the Pacific and Atlantic Oceans. The snow crab ( Chionoecetes opilio) was first reported in the Barents Sea (BAR) in 1996, presumably following introduction via Ballast water. Since then, the population has increased in size and distribution and has become self-reproducing and of economic importance. We implemented genetic analysis to identify the origin and pathway of introduction of BAR snow crab. Samples from BAR, Alaska, eastern Canada, and west Greenland were genotyped with 12 microsatellite loci. Pairwise FST between 15 samples showed three geographic clusters, each significantly different from one another. Unexpectedly, the largest genetic distance was between the BAR and Greenland clusters. This clustering may be the result of dispersals through Bering Strait from the North Pacific Ocean and passage through the Arctic Ocean. The BAR samples did not show signs of a bottleneck in population size, as would be expected after introduction of small numbers of individuals. Presence of snow crab in the BAR may thus be the result of recent natural range expansion from around Alaska.
The efficacy of mycotoxin binders to control mycotoxins in feeds and the potential risk of interactions with nutrient: a review
Authors: Kihal Abdelhacib , Rodríguez-Prado María , Calsamiglia Sergio 
Published: October 2022

AbstractMycotoxicosis are a common problem in livestock, where a group of six major mycotoxins represents a high risk for animal health and production profits. Mycotoxin binders (MTB) can reduce the mycotoxin burden in the gastrointestinal tract of the animal. Mycotoxin binders are classified in inorganic, as clays and activated carbon (AC), and organic, as yeast cell wall (YCW) and micro-ionized fibers. The adsorption of mycotoxins into MTB is due to: 1) chemical interactions where the cation exchange capacity involves different types of bounds like ion-dipole, Van der Walls forces, or hydrogen bonds; and 2) to physical characteristics of MTB like pore size, or mycotoxin structure and shape. The adsorption capacity of MTB is determined using different in vitro tests that mimic the gastrointestinal tract of the animals. A literature search was conducted to identify in vitro research where the efficacy of adsorption of MTB was determined. The search was based on 8 MTB [AC, bentonite, clinoptilolite, hydrated sodium calcium aluminosilicate (HSCAS), montmorillonite (MMT), sepiolite, YCW and zeolite] and 6 mycotoxins [aflatoxin (AF), deoxynivalenol (DON), fumonisin (FUM), ochratoxin (OTA), T-2 toxin and zearalenone (ZEA)]. Sixty-eight papers with 1842 data were selected and analyzed with the PROC MIXED of SAS. The response variable was the percentage mycotoxins adsorption by MTB, and the model included the fixed effects of MTB, mycotoxins, incubation media, pH and their interactions, and the random effect of the study. Differences were considered significant when P &lt; 0.05 and with tendency when 0.05 &lt; P &lt; 0.10. The mycotoxins adsorption capacity was 83% ± 1.0 for AC, 76% ± 3.1 for MMT, 62% ± 1.0 for bentonite, 55% ± 1.9 for HSCAS, 52% ± 9.1 for sepiolite, 52% ± 4.3 for clinoptilolite and 44% ± 0.4 for YCW. For mycotoxins, the adsorption of AF was 76% ± 0.6, for FUM was 50% ± 1.8, for OTA was 42% ± 1.0, for ZEA was 48% ± 1.1, for DON was 35% ± 1.6, and for T-2 was 27% ± 2.8. The pH affected the adsorption capacity of YCW with higher adsorption at low pH, and the adsorption of OTA and ZEA, where OTA adsorption tended to be lower at intermediate pH, and adsorption of ZEA tended to be higher at the two-steps pH. The potential adsorption of some essential nutrients, including amino acids and vitamins, should also be considered. Results should be used as a guide in the selection of the appropriate mycotoxin binder based on the predominant mycotoxin in feeds.
SeedTransNet: a directional translational network revealing regulatory patterns during seed maturation and germination
Authors: Bai Bing , Schiffthaler Bastian , van der Horst Sjors , Willems Leo , Vergara Alexander , Karlström Jacob , Mähler Niklas , Delhomme Nicolas , Bentsink Leónie , Hanson Johannes 
Published: October 2022

AbstractSeed maturation is the developmental process that prepares the embryo for the desiccated waiting period before germination. It is associated with a series of physiological changes leading to the establishment of seed dormancy, seed longevity, and desiccation tolerance. We studied translational changes during seed maturation and observed a gradual reduction in global translation during seed maturation. Transcriptome and translatome profiling revealed specific reduction in the translation of thousands of genes. By including previously published data on germination and seedling establishment, a regulatory network based on polysome occupancy data was constructed: SeedTransNet. Network analysis predicted translational regulatory pathways involving hundreds of genes with distinct functions. The network identified specific transcript sequence features suggesting separate translational regulatory circuits. The network revealed several seed maturation-associated genes as central nodes, and this was confirmed by specific seed phenotypes of the respective mutants. One of the regulators identified, an AWPM19 family protein, PM19-Like1 (PM19L1), was shown to regulate seed dormancy and longevity. This putative RNA-binding protein also affects the translational regulation of its target mRNA, as identified by SeedTransNet. Our data show the usefulness of SeedTransNet in identifying regulatory pathways during seed phase transitions.
Global ubiquitinome analysis reveals the role of E3 ubiquitin ligase FaBRIZ in strawberry fruit ripening
Authors: Wang Yuying , Kong Lingxi , Wang Weihao , Qin Guozheng 
Published: October 2022

AbstractUbiquitination is an important post-translational modification that mediates protein degradation in eukaryotic cells, participating in multiple biological processes. However, the profiling of protein ubiquitination and the function of this crucial modification in fruit ripening remain largely unknown. In this study, we found that suppression of proteasome by the inhibitor MG132 retarded strawberry fruit ripening. Using K-ɛ-GG antibody enrichment combined with high-resolution mass spectrometry, we performed a comprehensive ubiquitinome analysis in strawberry fruit. We identified 2947 ubiquitination sites for 2878 peptides within 1487 proteins, which are involved in a variety of cellular functions. The lysine at position 48 (K48)-linked poly-ubiquitin chains appeared to be the most prevalent type of modification among the identified ubiquitinated proteins. A large number of ubiquitination sites exhibited altered ubiquitination levels after proteasome inhibition, including those within ripening-related proteins associated with sugar and acid metabolism, cell wall metabolism, anthocyanin synthesis, and ABA biosynthesis and signalling. We further demonstrated that FaBRIZ, a RING-type E3 ligase, functions as a negative regulator of ripening in strawberry fruit. Our findings highlight the critical regulatory roles of protein ubiquitination in fruit ripening. The ubiquitinome data provide a basis for further exploration of the function of ubiquitination on specific proteins.
A study of the magnetic activity and variability of GJ 436
Authors: Kumar M , Fares R 
Published: October 2022

ABSTRACT
We present a magnetic activity study of GJ 436 using spectroscopic data from HARPS, spanning over 14 yr, and additional data from NARVAL, falling within the HARPS observations. We study the Ca ii H&K, He i D3, Na i doublet, H α, and Ca ii IRT triplets lines and explore linear correlations between them. Using the full HARPS data set, we found indices H α versus Ca ii H&K & H α versus He i to correlate positively. From the NARVAL data set, covering one observing epoch, we found Ca ii IRT3 versus Ca ii IRT2 & Ca ii IRT3 versus H α index to correlate negatively. We investigate long and short-term periodicity in these index variations, using the Generalized Lomb–Scargle periodogram. For Ca ii H&K, Na i and H α indices, we detect long-term periods of 2470.7 d (∼ 6.8 yr), 1861.6 d (∼ 5.1 yr), and 2160.9 d (∼ 5.9 yr) respectively, consistent with GJ 436’s photometric cycle of ∼ 7.4 yr. Applying the ‘Pooled Variance’ technique to H α & Na i indices, we found ∼ 2500 d to be the period of an activity cycle mechanism, in good agreement with the detected 2470.7 d period. For Ca ii H&K and H α indices, we detect short-term periods of $39.47^{+0.11}_{-0.15}$ d and $40.46^{+0.44}_{-0.52}$ d, respectively, identified as the stellar rotation period. The stellar rotation is detected after pre-whitening the long-term periodicity. It is detected as well in the analysis of individual observing epochs.
Torque reversals and wind variations of X-ray pulsar Vela X-1
Authors: Liao Zhenxuan , Liu Jiren , Gou Lijun 
Published: October 2022

ABSTRACT
The erratic spin history of Vela X-1 shows some continuous spin-up/spin-down trend over tens of days. We study the orbital profile and spectral property of Vela X-1 in these spin-up/spin-down intervals, using the spin history monitored by Fermi/GBM and light curve from Swift/BAT and MAXI/GSC. The BAT fluxes in the spin-up intervals are about 1.6 times those of the spin-down intervals for out-of-eclipse orbital phases. The spin-up intervals also show a higher column density than the spin-down intervals, indicating that there is more material on the orbital scale for the spin-up intervals. It could be due to the variation of the stellar wind of the optical star (HD 77581) on tens of days. The varying wind could lead to alternating prograde/retrograde accreting flow to the neutron star, which dominates the transfer of the angular momentum to Vela X-1, but not the total observed luminosity.
Efficacy of belimumab in patients with systemic lupus erythematosus from North East Asia: Results of exploratory subgroup analyses
Authors: Zheng Jie , Gu Jieruo , Su Yin , Li Yang , Li Xingfu , Xiong Cui , Cao Hua , Quasny Holly , Chu Myron , Curtis Paula , DeRose Kathleen , Kurrasch Regina , Meizlik Paige , Roth David A , Zhang Fengchun 
Published: October 2022

ABSTRACT

Objectives
To assess belimumab efficacy in patients from North East Asia (NEA) with systemic lupus erythematosus (SLE) in baseline demographic/disease characteristic subgroups.

Methods
This analysis of patient subgroups from BLISS-NEA (GSK Study 113750; NCT01345253) studied adults with SLE randomized to belimumab (10 mg/kg intravenous) or placebo. Primary endpoint, SLE Responder Index 4 (SRI-4) response rate at Week 52, was analysed in subgroups defined by gender, country, prednisone-equivalent dose, concomitant medications, Safety of Estrogens in Lupus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) score, complement (C) levels, anti-double-stranded deoxyribonucleic acid (dsDNA) positivity, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index score.

Results
Patients (overall population: N = 677; belimumab: n = 451, placebo: n = 226) were from China (76.4%), Korea (14.8%), and Japan (8.9%). The mean age was 32.1 years; 92.9% were female. In the overall population, more belimumab (53.8%) than placebo (40.1%) patients were SRI-4 Week 52 responders (p = .0001). SRI-4 response rates by subgroups were generally consistent with the overall population. A greater response with belimumab was seen in patients with a baseline SELENA-SLEDAI score ≥10 versus ≤9 and patients with low C3/C4 levels and anti-dsDNA positive at baseline versus those ‘NOT’ (low C3 and/or C4 and anti-dsDNA positive).

Conclusions
These findings continue to support the efficacy of belimumab in SLE.