bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the Interface of Y3Fe5O12/Gd3Ga5O12 Structure Obtained by the Liquid Phase Epitaxy
Authors: Syvorotka Ihor I. , Sugak Dmytro , Yakhnevych Uliana , Buryy Oleh , Włodarczyk Damian , Pieniążek Agnieszka , Zhydachevskyy Yaroslav , Levintant‐Zayonts Neonila , Savytskyy Hrygoryy , Bonchyk Oleksandr , Ubizskii Sergij , Suchocki Andrzej 
Published: February 2022

AbstractThe changes in the optical, structural, mechanical properties, and chemical composition of Y3Fe5O12/Gd3Ga5O12 (YIG/GGG) single crystal structures grown by liquid phase epitaxy, particularly at the interface between the film (Y3Fe5O12) and the substrate (Gd3Ga5O12), are studied. Different complementary techniques, including optical microscopy, local spectrophotometry, electron probe microanalysis, micro‐Raman spectroscopy, and nanohardness analysis are used. The main finding of the study is an experimental approach, in which the probe of the measuring device (light beam, electron beam, nanoindenter) is directed to the surface of the studied sample in a direction perpendicular to the direction of structure growth, and the surface is scanned along this direction. It allows to obtain the profiles of changes in refractive properties, nanohardness, optical absorption, chemical composition, and intensity of phonon spectrum bands at the transition from the GGG to YIG. It is established that the lengths of the scanning intervals, at which the changes of various properties of a specimen occur, differ significantly. The obtained results are affected by the size of the probes and by the sensitivities of both the particular measuring method and the particular physical property of the material to changes in the chemical composition and crystalline structure of the sample.
Facile Synthesis and Characterization of CuO–CeO2 Nanostructures for Photocatalytic Applications
Authors: Arfan Muhammad , Hussain Intisar , Ahmad Zahoor , Afzal Andleeb , Shahid Tauseef , Wattoo Abdul Ghafar , Rafi Muhammad , Zeb Aurang , Shahzad Muhammad Imran , Zhenlun Song 
Published: February 2022

AbstractA simple approach composite hydroxide mediated technique is applied successfully for the preparation of efficient CuO and CuO–CeO2 photocatalysts. The structural, morphological, and optical characteristics of synthesized photocatalysts are probed by X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), energy dispersive X‐ray (EDX), and UV–vis spectroscopy. The XRD and XPS reveal the successful formation of pure CuO and CuO–CeO2 nanocomposite structures. Spherical, nanorods, nanosheets poly edge type peculiarities are found in SEM images. EDX backs the results of XRD and XPS. Bandgap energy of synthesized photocatalysts is found between 1.49 and 1.36 eV indicating red shift. Compared with pure CuO photocatalysts the CuO–CeO2 composites effectively degrade the MB dye. The efficiency of CuO/CeO2 (90:10) nanocomposite exhibit 99.01% efficiency and follow the pseudo first order kinetic reaction.
COF‐5/CoAl‐LDH Nanocomposite Heterojunction for Enhanced Visible‐Light‐Driven CO2 Reduction
Authors: Ou Siyong , Zhou Min , Chen Wen , Zhang Yuyao , Liu Yueli 
Published: February 2022

AbstractPhotocatalytic conversion of CO2 into value‐added chemical fuels is an attractive route to mitigate global warming and the energy crisis. Reasonable design of optical properties and electronic behavior of the photocatalyst are essential to improve their catalytic activity. Herein, the 1D/2D heterojunction by direct in‐situ synthesis of the covalent organic framework (COF)‐5 colloid on the surface of CoAl layered double hydroxide (LDH) was used as the prospective photocatalyst for CO2 reduction. COF‐5/CoAl‐LDH nanocomposite achieved 265.4 μmol g−1 of CO with 94.6 % selectivity over CH4 evolution in 5 h under visible light irradiation, which was 4.8 and 2.3 times higher than those of COF‐5 colloid and CoAl‐LDH, respectively. The enhanced catalytic activity was derived from the increased visible‐light activity and the construction of type II‐2 heterojunction, which greatly optimized visible light harvesting and accelerated the efficient separation of the photoinduced holes and electrons. This work paves the way for rational design of heterojunction catalysts in photocatalytic CO2 reduction.
Comb decimator design based on symmetric polynomials with roots on the unit circle: Two‐stage multiplierless design and improved magnitude characteristic
Authors: Jovanovic Dolecek Gordana 
Published: February 2022

AbstractThis paper presents a theoretical background for design of comb decimator based on theorem of symmetric polynomials with roots on the unit circle. A simple multiplierless filter, called zero‐separation (ZS) filter, which separates doubled comb zeros, is derived. The separation of doubled comb zeros improves comb aliasing rejection. In order to get more benefits of the ZS filter, a two‐stage structure is considered. The classic comb filters are in both stages of the proposed structure. Additionally, in the second stage, a ZS filter is inserted to improve comb aliasing rejection. The passband droop is compensated by the compensator which works at low rate and is designed using particle swarm optimization (PSO). The method is illustrated with various examples. The comparisons with methods from literature prove the benefits of the proposed work.
Potential for replacing warfarin with a direct oral anticoagulant for endoscopic mucosal resection in the colorectum: A multicenter, open‐label, randomized controlled trial
Authors: Yamada Takuya , Kuwai Toshio , Sasaki Yoshihiro , Sakakibara Yuko , Uraoka Toshio , Kato Motohiko , Watanabe Noriko , Kimura Toshihisa , Kada Akiko , Saito Akiko M. , Harada Naohiko 
Published: February 2022

AbstractObjectivesThis study aimed to evaluate the efficacy and safety of apixaban replacement (AR) as an alternative to heparin bridging (HB) in patients taking warfarin and scheduled for endoscopic mucosal resection (EMR) in the colorectum.MethodsThis trial was conducted at seven institutes in Japan between May 2016 and May 2018. Enrolled patients had been taking oral warfarin and were diagnosed within 3 months with colorectal polyps for which EMR was indicated. Patients were randomly assigned to receive HB or AR. The primary endpoint was the incidence of postoperative bleeding. Secondary endpoints were the length of hospital stay, therapeutic endoscopy outcomes, and adverse events.ResultsThe planned sample size was 160 patients, but due to a decrease in the number of patients taking warfarin, the target number of cases could not be achieved within the case enrollment period, 44 cases were enrolled. They were divided into HB and AR groups. The incidence of postoperative bleeding was 15% (3/20) in HB and 0% in AR (P = 0.199). The total number of postoperative bleeding events was five in HB and none in AR. The length of hospital stay was significantly shorter in AR than in HB (median: 3.0 vs. 13.5 days, p < 0.001). There were no serious adverse events and no cerebral infarction/systemic embolism events.ConclusionAR for colorectal EMR may prove safe and has the potential to shorten hospital stay and reduce medical costs, though we were unable to evaluate the primary endpoint due to insufficient sample size.
Bisubstrate Strategies to Target Methyltransferases
Authors: Ahmed‐Belkacem Rostom , Debart Françoise , Vasseur Jean‐Jacques 
Published: February 2022

AbstractBisubstrate strategies address the lack of specificity encountered with S‐adenosyl‐L‐methionine (SAM) analogues targeting methyltransferases (MTases). Specifically, a bisubstrate inhibitor mimics the transition state complex associating a substrate and the SAM methyl group donor to a particular methyltransferase. These potential inhibitors contain both parts of the substrate and the methyl group donor. In this review, bisubstrate inhibitors of several MTases including DNA, RNA, protein, catechol or nicotinamide MTases are discussed in order to evaluate the interest of these promising molecules for the development of selective therapeutics against cancers, neuropsychiatric disorders and viral infections.
Inhibition of Oocyte Maturation by Malathion and Structurally Related Chemicals in Zebrafish (Danio rerio) After In Vitro and In Vivo Exposure
Authors: Miller Justin G.P. , Van Essen Darren , Brinkmann Markus , Raza Yamin , Dubiel Justin , Fujita Kaden K. , Doering Jon A. , Wiseman Steve B. 
Published: February 2022

Abstract
Oogenesis is the process by which a primary oocyte develops into a fertilizable oocyte, making it critical to successful reproduction in fish. In zebrafish (Danio rerio), there are five stages of oogenesis. During the final step (oocyte maturation), the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (MIH) activates the membrane progestin receptor, inducing germinal vesicle breakdown. Using in vitro assays, it has been shown that anthropogenic stressors can dysregulate MIH-induced oocyte maturation. However, it is unknown whether the in vitro assay is predictive of reproductive performance after in vivo exposure. We demonstrate that a known inhibitor of oocyte maturation, malathion, and a structurally related chemical, dimethoate, inhibit oocyte maturation. However, malaoxon and omethoate, which are metabolites of malathion and dimethoate, did not inhibit oocyte maturation. Malathion and dimethoate inhibited maturation to a similar magnitude when oocytes were exposed for 4 h in vitro or 10 days in vivo, suggesting that the in vitro zebrafish oocyte maturation assay might be predictive of alterations to reproductive performance. However, when adult zebrafish were exposed to malathion for 21 days, there was no alteration in fecundity or fertility in comparison with control fish. Our study supports the oocyte maturation assay as being predictive of the success of in vitro oocyte maturation after in vivo exposure, but it remains unclear whether inhibition of MIH-induced oocyte maturation in vitro correlates to decreases in reproductive performance. Environ Toxicol Chem 2022;41:1381–1389. © 2022 SETAC
Abstract
The ability of oocyte maturation assays to predict reproductive performance in zebrafish. Maturation inducing hormone (MIH) stimulated maturation of oocytes after in vitro exposures to selected chemicals was predictive of the success of oocytes to mature in vitro after in vivo exposure. However, oocyte maturation assays using in vitro exposures were not predictive of reproductive performance during a 21-day reproduction assay.
Formulation and characterization of physicochemical, functional, morphological, and antioxidant properties of cassava‐based rice analogue
Authors: Liu Chiew Yen , Amani Raihan , Sulaiman Syazana , Mahmood Kaiser , Ariffin Fazilah , Mohammadi Nafchi Abdorreza 
Published: February 2022

AbstractThis study aimed to develop a cassava‐based rice analogue with improved nutritional value as an alternative to commercial white rice. The rice analogue formulations (RAFs) were developed by the substitution of modified cassava flour (MOCAF) with rice flour at different ratios as 1:0, 7:3, 5:5, 3:7, and 0:1, followed by the addition of cassava leaves (0, 10, and 20 wt%). The developed rice analogues were evaluated for physicochemical, functional, morphological, and antioxidant properties. The rice analogue containing a 5:5 ratio of rice flour to MOCAF (RAF 2) added with 20% cassava leaves presented the most desirable nutritional composition and functional properties. However, RAF 4 (100% MOCAF with 20% cassava leaves) showed the highest total polyphenol content (TPC) (198.8 mg gallic acid equivalent (GAE)/100 g), total chlorophyll content (TCC) (198 mg/ml), 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) inhibition (79%), and ferric reducing antioxidant power (FRAP) inhibition (85%). Hence, the addition of MOCAF and cassava leaves improved the nutritional value of cassava‐based rice analogues, which could be a healthy alternative to commercial rice in the daily diet.
Cedrus atlantica extract exerts antiproliferative effect on colorectal cancer through the induction of cell cycle arrest and apoptosis
Authors: Huang Chih‐Yuan , Chien Ju‐Huei , Chang Kai‐Fu , Hsiao Chih‐Yen , Huang Ya‐Chih , Chen Yi‐Ting , Hsu Ming‐Yi , Hsieh Ming‐Chang , Tsai Nu‐Man 
Published: February 2022

Abstract
Cedrus atlantica is a tree species found in Morocco with many clinical benefits in genitourinary, musculoskeletal, and skin systems. Previous studies have reported that extracts of Cedrus atlantica have antioxidant, antimicrobial, and anticancer properties. However, its role in colorectal cancer (CRC) remains unclear. The present study investigated the effects and underlying mechanisms of Cedrus atlantica extract (CAt) using HT‐29 (human colorectal adenocarcinoma) and CT‐26 CRC cell lines. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay was performed to measure cell viability. Flow cytometry analysis and terminal deoxynucleotidyl transferase dUTP nick‐end labeling (TUNEL) assay were used to study the cell cycle and cell apoptosis, respectively. The expression of cell cycle and apoptosis‐associated proteins was detected by western blotting or immunohistochemical (IHC) staining. CAt showed significant inhibitory effects on the proliferation of HT‐29 and CT‐26 cells, and combined with the clinical drug, 5‐fluorouracil (5‐FU), exhibited synergistic effects. CAt induced cell cycle arrest at the G0/G1 phase through the upregulation of p53/p21 and the downregulation of cyclin‐dependent kinases (CDKs)/cyclins. In addition, CAt‐treated cells exhibited chromatin condensation, DNA fragmentation, and apoptotic bodies, which are typical characteristics of apoptosis activated via both the extrinsic (Fas ligand (FasL)/Fas/caspase‐8) and intrinsic (Bax/caspase‐9) pathways. Importantly, CAt suppressed tumor progression and prolonged the life span of mice within a well‐tolerated dose. Therefore, our findings provide novel insights into the use of CAt for the treatment of CRC.
Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer
Authors: Kim Hugh A. J. , Zeng Peter Y. F. , Sorgini Alana , Shaikh Mushfiq H. , Khan Halema , MacNeil Danielle , Khan Mohammed I. , Mendez Adrian , Yoo John , Fung Kevin , Lang Pencilla , Palma David A. , Mymryk Joe S. , Barrett John W. , Patel Krupal B. , Boutros Paul C. , Nichols Anthony C. 
Published: February 2022

AbstractBackgroundNumerous studies of head and neck squamous cell carcinoma (HNSCC) have demonstrated disparate outcomes by race and ethnicity. Beyond known associations with socioeconomic variables, whether these are also associated with differences in tumor molecular composition has thus far been poorly explored.MethodsWe downloaded clinical and multiplatform molecular data from The Cancer Genome Atlas and other published studies. These were compared between non‐Hispanic Black (n = 43) and White (n = 354) patients with non‐HPV‐related tumors, using multivariable models. Publicly available validation cohorts were used.ResultsBlack patients had poorer progression‐free survival than White patients. Tumors of Black patients had greater copy number aberrations, and increased SFRP1 methylation and miRNA‐mediated PRG4 silencing associated with poor survival. PI3K/AkT/mTOR pathway proteins were differentially expressed.ConclusionsThere are molecular differences between tumors of Black and White patients that may partially account for differences in survival. These may inform targeted treatment decisions to achieve equitable outcomes.
Costs of unnecessary repeated diagnostic tests in cholecystectomy
Authors: Aslan Hüseyin , Top Mehmet 
Published: February 2022

AbstractThe purpose of this study was to calculate the number, rate and cost of unnecessarily repeated tests on the patients who underwent open cholecystectomy and laparoscopic cholecystectomy and figure out the share of the unnecessarily repeated test costs in total test expenditures and total treatment expenditures. Alkaline phosphatase, alanine aminotransferase, aspartate transaminase, gamma glutamyl transferase, Total bilirubin, whole abdominal ultrasonography, upper abdominal ultrasonography, hepatobiliary ultrasonography tests, which were among the tests used in the patients who underwent cholecystectomy. The research group included 1296 patients. All records of the patients within totally 180 days of period including 90 days of pre‐cholecystectomy and 90 days of post‐cholecystectomy period were analysed. Necessity/Unnecessary criteria of the tests were identified in accordance with literature data, expert opinions and American Society of Anaesthesiologists Physical Status Classification scores. It was determined that unnecessary test costs consisted of 8.48% of the total test costs and 0.93% of the total treatment expenditures. This study showed that age, gender, surgical technique, and American Society of Anesthesiologists scores significantly differentiated unnecessary repeated test costs. Reducing the use of excessive health service and the related health expenditures, working to reveal its financial and medical benefits are crucial for the reimbursement agency, health service hosts and patients.
Electroosmotic flow of fractional Oldroyd‐B fluid through a vertical microchannel filled with a homogeneous porous medium: Numerical and semianalytical solutions
Authors: Alsharif Abdullah M. , Abdellateef Ahmed I. , Elmaboud Yasser Abd 
Published: February 2022

AbstractIn this manuscript, numerical and semianalytical solutions of electroosmotic flow of fractional Oldroyd‐B fluid through a vertical microchannel filled with a porous medium have been investigated. The fractional Cattaneo model is used to alter the energy equation. The Laplace and finite Fourier sine transforms have been used to get the semianalytical solutions as well as the finite difference method as a numerical solution. The results show that there is an excellent agreement between the two solutions. Moreover, the surge in velocity, flow rate, and heat transfer is extremely noticeable at the beginning of the time interval for various physical characteristics. Furthermore, as time passes, this phenomenon will reduce, and they will attain a steady state. Due to the existence of a different distribution of charges in the EDL at the channel walls, the velocity profile becomes asymmetric.
Dihydroquercetin improves rotenone‐induced Parkinsonism by regulating NF‐κB‐mediated inflammation pathway in rats
Authors: Akinmoladun Afolabi C. , Famusiwa Courage D. , Josiah Sunday S. , Lawal Akeem O. , Olaleye Mary T. , Akindahunsi Afolabi A. 
Published: February 2022

AbstractThis study examined the effect of dihydroquercetin (DHQ), also knofigurewn as taxifolin, on rotenone‐induced Parkinsonism in rats. Male Wistar rats were administered 1.5 mg/kg rotenone for 10 days and subsequently treated with 0.25–1.0 mg/kg DHQ for 3 days followed by the assessment of parkinsonian symptoms. Brain striatal redox stress and neurochemical dysfunction markers were assessed spectrophotometrically. Histopathological evaluation of the striatum was done by hematoxylin and eosin staining technique. The expression of genes involved in the activation of NF‐κB signaling pathway (IL‐1β, TNF‐α, NF‐κB and IκKB), and the p53 gene in the striatum were determined by RT‐qPCR. DHQ attenuated parkinsonian symptoms as well as striatal redox stress, neurochemical dysfunction, and histological alterations occasioned by rotenone toxicity. Importantly, DHQ significantly suppressed the rotenone‐induced upregulation of IL‐1β, NF‐κB, and IκKB expression (p < 0.05) in the striatum of parkinsonian rats. DHQ demonstrated notable neurotherapeutic potential against rotenone‐induced Parkinsonism in rats by improving parkinsonian symptoms (bradykinesia, catalepsy, postural instability, impaired locomotor behavior, and tremor) and neurochemical dysfunctions via modulation of genes involved in the activation of the canonical pathway of NF‐κB‐mediated inflammation.
Grade‐dependent changes in sphingolipid metabolism in clear cell renal cell carcinoma
Authors: Młynarczyk Grzegorz , Mikłosz Agnieszka , Suchański Jarosław , Reza Safoura , Romanowicz Lech , Sobolewski Krzysztof , Chabowski Adrian , Baranowski Marcin 
Published: February 2022

AbstractThere is a host of evidence for the role of bioactive sphingolipids in cancer biology, and dysregulated sphingolipid metabolism was observed in many malignant tumors. The aim of the present study was to provide more detailed data on sphingolipid metabolism in different stages of clear cell renal cell carcinoma (ccRCC). Samples of the tumor and noncancerous fragments of the same kidney were collected from patients who underwent a radical nephrectomy. The subjects were stratified according to the degree of malignancy of the tumor (n = 14 for G2, 12 for G3, and 9 for G4). The content of bioactive sphingolipids/glycosphingolipids was measured with an HPLC and HPTLC method, and the mRNA and protein expression of sphingolipid transporters and metabolizing enzymes was evaluated using real‐time polymerase chain reaction (PCR) and Western blot, respectively. Compared to healthy kidney tissue, ccRCC was characterized by accumulation of sphingosine, sphingosine‐1‐phosphate (S1P), ceramide, dihydrosphingosine, and dihydroceramide. However, in the case of the latter two, the accumulation was limited to higher malignancy grades. In addition, compared to the healthy tissue, the content of gangliosides in the tumor was increased at the expense of globosides. We also found profound grade‐dependent changes in the mRNA level of S1P‐metabolizing enzymes, and spinster homolog 2. In general, their expression was much higher in G2 tumors compared to higher malignancy grades. We conclude that ccRCC is characterized by profound and multilevel alterations in sphingolipid metabolism, which to a large extent are grade‐dependent. We hypothesize that dysregulation of sphingolipid metabolism contributes to the progression of ccRCC.
Development of a climate‐informed analog downscaling method for Asian regions
Authors: Kim Seon‐Ho , Kim Jeong‐Bae , Bae Deg‐Hyo 
Published: February 2022

AbstractThe importance of global circulation model data have been increased for climate change adaptation and natural hazard mitigation. Constructed analog is one of a common statistical downscaling methodology for spatial downscaling of large domain. It has challenges to reproduce extreme climate and wet‐dry conditions due to combination of multiple analogs. To address this challenge, localized constructed analog (LOCA) method was developed. The global applicability of LOCA has not been reviewed, and there is a limitation in that the analog domain is spatially discontinuous and too extensive for localization. Therefore, in this study, the global applicability of the localized analog method was evaluated for the Asia region, and the bias corrected climate informed analog (BCIA) method, a localized analog method based on climate information, was proposed to overcome the limitation of existed method. The localized analogs have 7–36% higher skill for monthly and seasonal climate and at least 20 higher skill score for climate indices than unlocalized analog. Localized methods have significant advantages in reproducing the extreme and the wet‐dry indices. Therefore, the global applicability of the localized analog method was confirmed. The analog dates in BCIA showed highly better qualities than those of LOCA. In downscaling performance, BCIA was superior to LOCA, and, it has a significant advantage in the index related to precipitations by more than 10% in skill score. Therefore, in the global application of localized techniques, BCIA can be utilized as a promising method.