bluuebunny/crossref_metadata_2025_split huggingface dataset:
Media Pembelajaran Menggunakan Teknologi Augmented Reality untuk Tanaman Daun Herbal
Authors: Latifah Ayu , Tresnawati Dewi , Sanjaya Hariyana 
Published: December 2022

Tanaman daun herbal memiliki potensi untuk menjadi alternatif pengobatan dan peningkatan daya saing ekonomi nasional karena Indonesia merupakan salah satu negara yang memiliki keanekaragaman hayati yang tinggi. mengenal tanaman daun herbal merupakan salah satu materi pembelajaran yang diberikan kepada anak Sekolah Dasar yang terdapat pada mata pelajaran Ilmu Pengetahuan Alam. Seiring dengan mengikuti perkembangan zaman, media untuk menyampaikan suatu informasi terus mengalami perkembangan dari waktu ke waktu, dari mulai dengan menggunakan buku, pembelajaran langsung dilapangan, video edukasi dan teknologi-teknologi terbaru lain yang baru dikemukakan salah satunya adalah dengan Augmented Reality. Dengan adanya perkembangan teknologi Augmented Reality ini, dibuat penelitian yang ditujukan untuk membangun suatu media pembelajaran mengenal tanaman daun herbal secara interaktif yang untuk siswa kelas 4 Sekolah Dasar sebagai bahan bantu ajar di dalam kelas dalam memahami isi materi yang ada, Dengan dibuatnya penelitian ini, diharapkan mampu meningkatkan minat siswa dalam mempelajari tanaman daun herbal yang terdapat disekitar lingkungan mereka. Penelitian dilakukan dengan menggunakan metodologi Research & Development yang terdiri dari tahapan analisis potensi dan masalah, pengumpulan data, desain produk, validasi desain, revisi desain, uji coba produk, revisi produk, uji coba pemakaian, hasil produk dan publikasi produk. Adapun hasil dari penelitian ini merupakan berupa produk aplikasi yang digunakan sebagai media pembelajaran pengenalan tanaman daun herbal untuk siswa Sekolah Dasar yang dikemas kedalam bentuk platform android untuk mengoperasikannya.
Sistem Informasi Geografis Pemetaan Lahan Garapan Serikat Petani Pasundan Kabupaten Garut
Authors: Nuraeni Fitri , Supriatna Asep Deddy , Bachtiar Amarullah 
Published: December 2022

Dalam pelaksanaan Reforma Agraria saat ini, serikat tani harus mampu mengumpulkan dan mengkonsolidasikan data objek dan subjek Reforma Agraria yang akan diusulkan melalui percepatan Lokasi Prioritas Reforma Agraria (LPRA). Namun serikat tani yang tergabung di Serikat Petani Pasundan (SPP), dalam pengelolaan data objek dan subjeknya masih menggunakan pencatatan dikertas, sehingga data rentan hilang, minimnya dalam akses informasi mengenai lahan garapan dan sulitnya dalam melakukan survey lokasi. Oleh karena itu sistem informasi geografis menjadi hal yang dibutuhkan oleh Serikat Petani Pasundan Kabupaten Garut sebagai sumber informasi lahan garapan dan bahan usulan kelengkapan administratif Lokasi Prioritas Reforma Agraria (LPRA), pembangunan sistem ini menggunakan metodologi Rational Unified Process (RUP) dengan tahapan inception, elaboration, construction dan transition serta menggunakan pemodelan Unified Modelling Language (UML). Dengan adanya sistem informasi geografis pemetaan lahan garapan ini, pengelolaan data objek dan subjeknya di lingkungan serikat petani Pasundan Kabupaten Garut menjadi lebih baik dan dapat menjadi suatu informasi yang cepat, tepat dan akurat.
Experimental study on consolidation characteristics of deep clayey soil in a typical subsidence area of the North China Plain
Authors: Liu Fengjunnan , Qi Jianfeng , Guo Haipeng , Wang Yunlong , Guo Kaijie , Zang Xisheng 
Published: December 2022

Land subsidence is an important environmental problem in the North China Plain (NCP). A typical subsidence area mainly located on adjoining areas of Beijing and Hebei provinces was selected to study the consolidation characteristics of deep clayey soil. Clay samples were collected from 14 boreholes at different depths, and the compression and consolidation behavior of the soil was analyzed by high-pressure oedometer tests. Results show that the deformation amount and deformation stabilization time in the primary consolidation stage increase with the load but decrease with the sampling depth. The nonlinear compression model of e-log(p) does not fit well for deep normally-consolidated clayey soil, the log(e+ec)–logp model fit the shallow clayey soil better than the deep clayey soil, and the hyperbolic model fits almost all soil samples well. Based on statistical theory, the soil consolidation equation CE_NCP was established for calculating the relationship between the degree of consolidation and the time factor in subsidence areas. The equations were fitted with the data obtained from high-pressure consolidation tests to obtain three parameters a, b and c, which are applied to the consolidation calculations for soil samples at depths of 0–100 m, 100–200 m, 200–300 m and 300–400 m, respectively. The applicability of CE_NCP equation was evaluated by comparing it to the analytical solution of Terzaghi’s consolidation equation, results showing that CE_NCP equation is more suitable for the calculation of the consolidation in the study area than the Terzaghi’s analytical solution. Eventually, the CE_NCP equation was successfully used to estimate the degree of consolidation in a subsidence area of Lang Fang City in the NCP.
Fibroblast growth factor 23 level modulates the hepatocyte’s alpha-2-HS-glycoprotein transcription through the inflammatory pathway TNFα/NFκB
Authors: Mattinzoli Deborah , Li Min , Castellano Giuseppe , Ikehata Masami , Armelloni Silvia , Elli Francesca Marta , Molinari Paolo , Tsugawa Koji , Alfieri Carlo Maria , Messa Piergiorgio 
Published: December 2022

IntroductionHigh serum levels of fibroblast growth factor 23 (FGF23) characterize chronic kidney disease (CKD) since its early stages and have been suggested to contribute to inflammation and cardiovascular disease. However, the mechanisms linking FGF23 with these pathological conditions remain still incompletely defined. The alpha-2-HS-glycoprotein (AHSG), a liver-produced anti-inflammatory cytokine, is highly modulated by inflammation itself, also through the TNFα/NFκB signaling pathway. In our previous study, we found that FGF23 modulates the production of AHSG in the liver in a bimodal way, with stimulation and inhibition at moderately and highly increased FGF23 concentrations, respectively.MethodsThe present study, aiming to gain further insights into this bimodal behavior, was performed in hepatocyte human cells line (HepG2), using the following methods: immunochemistry, western blot, chromatin immunoprecipitation, fluorescence in situ hybridization (FISH), qRT-PCR, and gene SANGER sequencing.ResultsWe found that FGF23 at 400 pg/ml activates nuclear translocation of NFκB, possibly increasing AHSG transcription. At variance, at 1,200 pg/ml, FGF23 inactivates NFκB through the activation of two specific NFκB inhibitors (IκBα and NKIRAS2) and induces its detachment from the AHSG promoter, reducing AHSG transcription.ConclusionThese results add another piece to the puzzle of FGF23 involvement in the multifold interactions between CKD, inflammation, and cardiovascular disease, suggesting the involvement of the NFκB pathway, which might represent a potential therapeutic target in CKD.
Applying the Toyota production system to decrease the time required to transport patients undergoing surgery from the general ward to the operating room and reviewing the essence of lean thinking
Authors: Lin Chien-Chung , Chueh Jui-Wen , Chen Hung-Ming , Chiu Yao-Hui , Chu Dachen 
Published: December 2022

BackgroundSending a patient to the operating room is the first step in surgery. Delayed patient transport causes the patient to go hungry for a longer time, aggravating the patient’s physical discomfort and psychological stress. The issue of delays in transporting inpatients to the operating room has rarely been discussed in the literature. The Toyota production system is a famous and excellent scientific method of reducing waste and increasing efficiency. Our goal is to use the Toyota method to decrease the time required to transport the inpatient to the operating room and to review the concepts underlying lean thinking.MethodsWe employed an A3 8-step problem-solving process. A current value stream map featuring numerical data (concerning 46 patients) measured in the workplace was developed. The total time spent on transport was 53 min, but we expected patients to be transported within 30 min. We hoped to reduce the time wasted by half, i.e., by 23*50% = 12 min. These 12 min were saved by reducing the time spent on “waiting for an attendant at the ward” by 9 min and the time spent on “elevator transport” by 3 min. According to the value stream map featuring the time measurements, the root causes of delayed transportation can be divided into process-related, attendant-related, and elevator-related factors. We formulated 5 countermeasures. The ECRS (Eliminate, Combine, Rearrange, Simplify) technique was used to rearrange, combine, and simplify the existing process. Hospital executives established norms for attendant prioritization of work and rules for elevator use.ResultsAccording to the original indicators, all goals were attained. “Total time spent” decreased by 62.3%. The time required for attendants to report to the nursing station decreased by 56.5%. The time spent on elevator transport decreased by 44.4%. We developed a process for future use based on information-assisted patient and staff identification. Finally, we standardized successful processes.ConclusionThe seemingly trivial factors that delay patient transport are associated with seven types of waste. The A3 8-step problem-solving process is useful in this context. In proposing this improvement process, we believe that we are following the spirit of the Toyota production system.
The devil is in the details: Variable impacts of season, BMI, sampling site temperature, and presence of insects on the post-mortem microbiome
Authors: Tarone Aaron M. , Mann Allison E. , Zhang Yan , Zascavage Roxanne R. , Mitchell Elizabeth A. , Morales Edgar , Rusch Travis W. , Allen Michael S. 
Published: December 2022

BackgroundPost-mortem microbial communities are increasingly investigated as proxy evidence for a variety of factors of interest in forensic science. The reported predictive power of the microbial community to determine aspects of the individual’s post-mortem history (e.g., the post-mortem interval) varies substantially among published research. This observed variation is partially driven by the local environment or the individual themselves. In the current study, we investigated the impact of BMI, sex, insect activity, season, repeat sampling, decomposition time, and temperature on the microbial community sampled from donated human remains in San Marcos, TX using a high-throughput gene-fragment metabarcoding approach.Materials and methodsIn the current study, we investigated the impact of BMI, sex, insect activity, season, repeat sampling, decomposition time, and temperature on the microbial community sampled from donated human remains in San Marcos, TX using a high-throughput gene-fragment metabarcoding approach.ResultsWe found that season, temperature at the sampling site, BMI, and sex had a significant effect on the post-mortem microbiome, the presence of insects has a homogenizing influence on the total bacterial community, and that community consistency from repeat sampling decreases as the decomposition process progresses. Moreover, we demonstrate the importance of temperature at the site of sampling on the abundance of important diagnostic taxa.ConclusionThe results of this study suggest that while the bacterial community or specific bacterial species may prove to be useful for forensic applications, a clearer understanding of the mechanisms underpinning microbial decomposition will greatly increase the utility of microbial evidence in forensic casework.
Identification of a de novo mutation of the FOXG1 gene and comprehensive analysis for molecular factors in Chinese FOXG1-related encephalopathies
Authors: Lu Guanting , Zhang Yan , Xia Huiyun , He Xiaoyan , Xu Pei , Wu Lianying , Li Ding , Ma Liya , Wu Jin , Peng Qiongling 
Published: December 2022

BackgroundFOXG1-related encephalopathy, also known as FOXG1 syndrome or FOXG1-related disorder, affects most aspects of development and causes microcephaly and brain malformations. This syndrome was previously considered to be the congenital variant of Rett syndrome. The abnormal function or expression of FOXG1, caused by intragenic mutations, microdeletions or microduplications, was considered to be crucial pathological factor for this disorder. Currently, most of the FOXG1-related encephalopathies have been identified in Europeans and North Americans, and relatively few Chinese cases were reported.MethodsArray-Comparative Genomic Hybridization (Array-CGH) and whole-exome sequencing (WES) were carried out for the proband and her parent to detect pathogenic variants.ResultsA de novo nonsense mutation (c.385G&gt;T, p.Glu129Ter) of FOXG1 was identified in a female child in a cohort of 73 Chinese children with neurodevelopmental disorders/intellectual disorders (NDDs/IDs). In order to have a comprehensive view of FOXG1-related encephalopathy in China, relevant published reports were browsed and twelve cases with mutations in FOXG1 or copy number variants (CNVs) involving FOXG1 gene were involved in the analysis eventually. Feeding difficulties, seizures, delayed speech, corpus callosum hypoplasia and underdevelopment of frontal and temporal lobes occurred in almost all cases. Out of the 12 cases, eight patients (66.67%) had single-nucleotide mutations of FOXG1 gene and four patients (33.33%) had CNVs involving FOXG1 (3 microdeletions and 1 microduplication). The expression of FOXG1 could also be potentially disturbed by deletions of several brain-active regulatory elements located in intergenic FOXG1-PRKD1 region. Further analysis indicated that PRKD1 might be a cooperating factor to regulate the expression of FOXG1, MECP2 and CDKL5 to contribute the RTT/RTT-like disorders.DiscussionThis re-analysis would broaden the existed knowledge about the molecular etiology and be helpful for diagnosis, treatment, and gene therapy of FOXG1-related disorders in the future.
Exploring barriers to diversified dietary feeding habits among adolescents in the agrarian community, North West Ethiopia
Authors: Agedew Eskezyiaw , Abebe Zeweter , Ayelign Abebe 
Published: December 2022

IntroductionAdolescence is a critical and neglected age group of the population in any form of nutritional intervention. A comprehensive study that assesses barriers that influence their diversified feeding habit is not well investigated in qualitative approaches. Therefore, this study was conducted to fill this gap by providing evidence on exploring barriers to diversified feeding habits of adolescents in the agrarian community, North West Ethiopia.ObjectiveThe aim of the study was to explore barriers to diversified feeding habits of adolescents in the agrarian community, North West Ethiopia.MethodsA phenomenological qualitative study design was conducted among adolescents in the age group of 10–19 years, and adults in the age range of 25 to 64 years (representatives of farmers, agricultural, health, and education sectors). We conducted 24 in-depth interviews (12- adolescents, 4-health, 2- agricultural extension, 3-education, and 3-farmer representative) among purposively selected community groups. In-depth interview guides and observation checklist were utilized for data collection. The audio-recorded qualitative data were transcribed word by word into English. Finally, the translated data were exported to ATLAS ti version 7.1 software for thematic analysis based on inductive content analysis. All coded quotations, including memos written throughout the coding process, were then analyzed to identify themes inductively.ResultsDietary habit of adolescents in the study area was predominantly plant-based cereals with low protein, vitamins, and mineral contents. Adolescents have limited consumption of fruits, vegetables, and animal source foods. Adolescents with these feeding habits had suboptimal intake of micronutrients and proteins, which are crucial for their rapid growth stage. Individual-level barriers, family-level influence, dietary tradition of community, agricultural practice (poor agroforestry practice of the community, and poor agricultural practice to produce year-round diverse food items), and week multi-sectorial collaboration for nutritional intervention all influenced adolescent dietary habits.ConclusionMultiple layers of barriers influenced the diverse dietary habits of adolescents in the study setting. These multiple and interconnected influences ranged from individual level to multi-sectorial collaboration. Nutritional interventions should be implemented at the individual, family, agricultural, and multi-sectorial levels to improve adolescents’ diverse dietary habits.
The association between serum cadmium and diabetes in the general population: A cross-sectional study from NHANES (1999–2020)
Authors: Gong Rongpeng , Pu Xiaolu , Cheng Zhenqian , Ding Jie , Chen Zhenghao , Wang Yongjun 
Published: December 2022

BackgroundAssociations between serum cadmium and diabetes had been reported in previous studies, however there was still considerable controversy regarding associations. Studies in general population that investigated the effects of serum cadmium on diabetes were currently lacking. We designed this cross-sectional study among U.S. adults under high and low cadmium exposure to assess associations between serum cadmium and diabetes.MethodsThis cross-sectional study analyzed 52,593 adults who aged more than 20 years and participated in the National Health and Nutrition Examination Survey (NHANES), 1999–2020. The missing values and extreme values in the covariables were filled by multiple interpolation. Univariate logistics regression, multivariate logistics regression and smooth fitting curves were used to analyze the association between serum cadmium and diabetes. Simultaneously, sensitivity analysis was carried out by converting the serum cadmium from continuous variable to categorical variable. The stratification logistics regression model was used to analyze whether there were special groups in each subgroup to test the stability of the results.ResultsIn this cross-sectional study, serum cadmium levels were negatively correlated with the occurrence of diabetes in the low serum cadmium exposure group (OR = 0.811, 95% CI 0.698, 0.943; P = 0.007). There was no association between serum cadmium level and the occurrence of diabetes in the high serum cadmium exposure group (OR = 1.01, 95% CI 0.982, 1.037; P = 0.511). These results were consistent across all the subgroups (P for interaction &gt;0.05).ConclusionSerum cadmium was negatively associated diabetes among the representative samples of the whole population in the United States under the normal level of serum cadmium exposure. However, there was no association between serum cadmium level and the occurrence of diabetes in the high serum cadmium exposure group. This study promoted an update of new preventative strategy targeting environment for the prevention and control of diabetes in the future.
Case report: Chronic neutrophilic leukemia associated with monoclonal gammopathies. A case series and review of genetic characteristics and practical management
Authors: Vermeersch Gaël , Delforge Michel , Havelange Violaine , Graux Carlos , Michaux Lucienne , Devos Timothy 
Published: December 2022

Chronic neutrophilic leukemia (CNL) is a rare but potentially aggressive BCR::ABL1 negative myeloproliferative neoplasm, characterized by sustained mature, neutrophilic leukocytosis. The discovery of key driver mutations in the colony-stimulating-factor-3 receptor (CSF3R) gene resulted in the updated World Health Organization (WHO) diagnostic criteria in 2016. A significant number of CNL cases have been associated with plasma cell dyscrasias, predominantly multiple myeloma (MM) and monoclonal gammopathy of unknown significance (MGUS). Compared to pure CNL, mutated CSF3R is infrequently reported in CNL cases associated with monoclonal gammopathies (MG). Until now it remains unclear whether CNL and occurring plasma cell neoplasms are clonally related or CNL is developing secondary to the underlying dyscrasia. Owing to its rarity, currently no standard of care management exists for CNL and MG-associated CNL. In this case series we report the multi-center experience of five MG-associated CNL cases with a median age of diagnosis of 69 years. Three patients (66%) showed predominance of lambda light chain expression. Four (80%) eventually evolved to MM, and one CNL-MGUS patient developed secondary acute myeloid leukemia (AML). Mutated CSF3R was present in the patient who developed AML but was absent in other cases. To assess possible associated genetic aberrations we performed recurrent analysis with next-generation sequencing (NGS). Two patients (40%) deceased with a median time of survival of 8 years after CNL diagnosis. Three (60%) are currently in follow-up with no reoccurring leukocytosis. This case series, followed by a short review, provides a long-term clinical and genetic overview of five CNL cases associated with MG.
RecurIndex assay as an aid for adjuvant chemotherapy decisions in HR-positive HER2-negative breast cancer patients
Authors: Wang Haibo , Ma Li , Zhang Yanan , Wang Ouchen , Wei Zhimin , Xie Xiaohong , Zha Xiaoming , Zeng Jian , Lv Qing , Ren Yu , Wang Huimin , Du Furong , Cao Shangzhi 
Published: December 2022

BackgroundAdjuvant chemotherapy is a major adjuvant treatment modality for hormonal receptor (HR)-positive and HER2-negative early breast cancer, but only 2%-20% of patients derive practical benefits. How to balance its potential benefits and risks becomes a challenging clinical problem. The purpose of this study was to assess whether RecurIndex assay could serve as an aid for adjuvant chemotherapy decisions in Chinese patients with HR-positive HER2-negative early breast cancer.MethodsThe tissue samples of pT1-2N0 HR-positive HER2-negative breast cancer from multiple centers were detected using RecurIndex assay, based on which the patients were assigned into low- and high-risk groups. The survival outcomes of low- and high-risk patients including those with and without adjuvant chemotherapy were compared, and the risk factors for recurrence and metastasis were identified.ResultsTotally 445 patients were eligible for analysis. By contrast to high-risk patients, low-risk patients represented better 7-year recurrence-free survival (RFS), distant recurrence-free survival (DRFS) and local recurrence-free survival (LRFS) rates. For low-risk patients, no significant differences were shown between those with and without adjuvant chemotherapy in 7-year RFS, DRFS and LRFS rates. These differences were also inapparent between high-risk patients with and without adjuvant chemotherapy. The multivariate model revealed high-risk patients had a significantly elevated risk of recurrence and metastasis than those at low risk.ConclusionHR-positive HER2-negative early breast cancer patients at low risk stratified by RecurIndex assay might be exempt from adjuvant chemotherapy. Whether adjuvant chemotherapy may derive survival benefits for high-risk patients still needs larger cohorts to verify.