bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning‐based microarray cancer classification and ensemble gene selection approach
Authors: Rezaee Khosro , Jeon Gwanggil , Khosravi Mohammad R. , Attar Hani H. , Sabzevari Alireza 
Published: July 2022

AbstractMalignancies and diseases of various genetic origins can be diagnosed and classified with microarray data. There are many obstacles to overcome due to the large size of the gene and the small number of samples in the microarray. A combination strategy for gene expression in a variety of diseases is described in this paper, consisting of two steps: identifying the most effective genes via soft ensembling and classifying them with a novel deep neural network. The feature selection approach combines three strategies to select wrapper genes and rank them according to the k‐nearest neighbour algorithm, resulting in a very generalisable model with low error levels. Using soft ensembling, the most effective subsets of genes were identified from three microarray datasets of diffuse large cell lymphoma, leukaemia, and prostate cancer. A stacked deep neural network was used to classify all three datasets, achieving an average accuracy of 97.51%, 99.6%, and 96.34%, respectively. In addition, two previously unreported datasets from small, round blue cell tumors (SRBCTs)and multiple sclerosis‐related brain tissue lesions were examined to show the generalisability of the model method.
GaiaData Release 3
Authors: Frémat Y. , Royer F. , Marchal O. , Blomme R. , Sartoretti P. , Guerrier A. , Panuzzo P. , Katz D. , Seabroke G. M. , Thévenin F. , Cropper M. , Benson K. , Damerdji Y. , Haigron R. , Lobel A. , Smith M. , Baker S. G. , Chemin L. , David M. , Dolding C. , Gosset E. , Janßen K. , Jasniewicz G. , Plum G. , Samaras N. , Snaith O. , Soubiran C. , Vanel O. , Zorec J. , Zwitter T. , Brouillet N. , Caffau E. , Crifo F. , Fabre C. , Fragkoudi F. , Huckle H. E. , Lasne Y. , Leclerc N. , Mastrobuono-Battisti A. , Jean-Antoine Piccolo A. , Viala Y. 
Published: July 2022

Context.The third release of theGaiacatalogue contains radial velocities for 33 812 183 stars with effective temperatures ranging from 3100 K to 14 500 K. The measurements are based on the comparison of the spectra observed with the Radial Velocity Spectrometer (RVS; wavelength coverage: 846–870 nm, median resolving power: 11 500) to synthetic data broadened to the adequate along-scan line spread function. The additional line-broadening, fitted as it would only be due to axial rotation, is also produced by the pipeline and is available in the catalogue (field namevbroad).Aims.We describe the properties of the line-broadening information extracted from the RVS and published in the catalogue, and analyse the limitations imposed by the adopted method, wavelength range, and instrument.Methods.We used simulations to express the link between the line-broadening measurement provided inGaiaData Release 3 andVsini. We then compared the observed values to the measurements published by various catalogues and surveys (GALAH, APOGEE, LAMOST, etc.).Results.While we recommend caution in the interpretation of thevbroadmeasurement, we also find a reasonable general agreement of theGaiaData Release 3 line-broadening values and values in other catalogues. We discuss and establish the validity domain of the publishedvbroadvalues. The estimate tends to be overestimated at the lowerVsiniend, and atTeff > 7500 K its quality and significance degrade rapidly whenGRVS > 10. Despite all the known and reported limitations, theGaiaData Release 3 line-broadening catalogue contains measurements obtained for 3 524 677 stars withTeffranging from 3500 to 14 500 K, andGRVS < 12. It gathers the largest stellar sample ever considered for the purpose, and allows a first mapping of theGaialine-broadening parameter across the Hertzsprung-Russel diagram.
Vorkommen von kaniner Babesiose bei Hunden im Rhein-Main-Gebiet in Hessen – eine Fallstudie mit 81 Hunden
Authors: Seibert Stephanie , Rohrberg Antje , Stockinger Alexandra , Schaalo Stephanie , März Imke 
Published: July 2022

Zusammenfassung
Gegenstand und Ziel Die kanine Babesiose ist eine durch Dermacentor reticulatus übertragene Infektionskrankheit, die in Deutschland an Bedeutung gewinnt. Ziel der Studie war es, das vermehrte Vorkommen der kaninen Babesiose im Rhein-Main-Gebiet in Hessen, vor allem mit Akkumulation im Kreis Groß-Gerau, zu zeigen.
Material und Methode In die retrospektive Studie wurden Hunde aufgenommen, die im Zeitraum von Oktober 2018 bis Dezember 2020 in der Tierklinik vorgestellt wurden und anhand einer positiven Babesien-PCR die Diagnose einer kaninen Babesiose erhielten.
Ergebnisse Von den insgesamt 697 der in diesem Zeitraum durchgeführten Babesia spp.-PCR Untersuchungen waren 81 positiv (12 %). Bei 14 der 81 Babesien-positiv getesteten Hunde (17 %) wurde eine Sequenzierung durchgeführt (B. canis n = 13, B. vulpes n = 1). Zwei Hunde zeigten zeitgleich eine Anaplasmose. Auffällig ist, dass die Babesiose-Fälle ganzjährig mit Häufungen im März/April sowie im Oktober auftraten.In der Hämatologie konnte bei 44 von 81 Tieren (54 %) eine Panzytopenie nachgewiesen werden. Eine Anämie lag bei 66 (82 %), eine Thrombozytopenie bei 76 der 81 Patienten (94 %) vor. Nur bei 2 der 81 Fälle konnten keine hämatologischen Veränderungen festgestellt werden. Eine Hyperbilirubinämie fiel bei 66 der 73 gemessenen Bilirubinwerten (90 %) auf.Bei allen Tieren erfolgte eine Therapie mit zweimaliger Injektion von Imidocarb-Diproprionat (Carbesia®) im Abstand von 14 Tagen. Bei 37 der 81 Patienten (46 %) wurde eine Erfolgskontrolle mittels PCR durchgeführt. Bei den meisten dieser Patienten (92 %) konnte eine erfolgreiche Therapie durch eine negative Babesien-PCR bestätigt werden. Insgesamt 6 der 81 Patienten (7 %) wurden im Laufe der Behandlung eingeschläfert. Die Gründe für die Euthanasie waren progressive Nierenerkrankung, hochgradige intravaskuläre Hämolyse mit der Notwendigkeit von multiplen Bluttransfusionen sowie Bildung von Milz- und Nierenabszessen.
Schlussfolgerung Bei Hunden mit Symptomen wie Apathie, Pyrexie und Hämoglobinurie sowie hämatologischen Veränderungen im Sinne einer Anämie, Thrombozytopenie oder auch häufig einer Panzytopenie sollte eine Babesiose, unabhängig von der Jahreszeit, vor allem im Frühjahr und Herbst differentialdiagnostisch ausgeschlossen werden.
Rückfallverläufe von entlassenen Maßregelvollzugspatienten (§ 63 StGB) differenziert nach Diagnosegruppen
Authors: Klausing Hannah , Seifert Dieter 
Published: July 2022

ZusammenfassungZiel der Studie ist die deskriptive Beschreibung der Rückfallverläufe von 321 entlassenen Maßregelvollzugspatienten (§ 63 StGB). Die Daten entstammen der Essener prospektiven Langzeitstudie. Die Deliktrückfälle wurden in Zeiträumen von 3 Jahren aggregiert. Im Verlauf des durchschnittlich 16,5-jährigen Beobachtungszeitraums („time-at-risk“) beging etwa ein Drittel erneut Straftaten (35,2 %). Differenziert nach Hauptdiagnosen, wiesen insbesondere entlassene Patienten mit Persönlichkeitsstörungen hohe allgemeine Rückfallraten (57,8 %) auf. Bei aus Gründen der Verhältnismäßigkeit entlassenen Patienten (n = 8; 2,5 %), kam es in 4 Fällen zu einem Rückfall, in 3 Fällen zu einem schwerwiegenden Delikt. Die Ergebnisse unterstreichen die Effektivität des psychiatrischen Maßregelvollzugs und verdeutlichen den Bedarf zusätzlicher Überlegungen bezüglich geeigneter Behandlungsmaßnahmen und ambulanter Nachsorge für persönlichkeitsgestörte Rechtsbrecher.
Addition of Prucalopride to Standard Bowel Preparation Does Not Improve Colonic Mucosa Visualization—A Retrospective Observational Cohort Study
Authors: Singh Gaurav Kr , Chauhan Shamshersingh G. , Lad Saiprasad S. , Sethiya Pratik R. , Gattani Mayur G. , Walke Swapnil , Shah Mit , Pandey Vikas R. , Ingle Meghraj A. 
Published: July 2022

Abstract
Background Colonoscopy is currently gold standard for visualizing colonic mucosa. Presence of constipation is generally associated with poor bowel preparation. We compared effect on colonic cleansing when prucalopride was used as adjunct with polyethylene glycol (PEG) in patients of constipation.
Methods A retrospective study was conducted at our center. One 70 patients with constipation were enrolled in two groups of who took only PEG and other of prucalopride plus PEG+ for bowel preparation. They underwent colonoscopy by a single-blinded experienced endoscopist. Bowel preparation quality was reported by Boston bowel preparation scale prior to washing or suctioning. The groups were analyzed for bowel preparation quality and side effects in either groups based on preformed questionnaire.
Results Mean Boston Stool preparation Score (BSS) in PEG group (5.33 ± 1.43) was slightly higher than PEG+ (5.16 + 1.37) (p-value =0.44). The total number of patients with side effects was higher in PEG+ group than PEG group. (p < 0.05).
Conclusion We conclude addition of prucalopride has no additional benefit when added with standard bowel preparation in patients of constipation. It may rather lead to noncompliance and inferior bowel preparation due to increased side effects.
Imaging Tips and Tricks in Management of Renal and Urothelial Malignancies
Authors: Sanyal Shanti Ranjan , Arora Ankur , Nisreen Amin , Mohamed Khattab , Mohammad Saeed Kilani , Baruah Deb 
Published: July 2022

AbstractManagement of urological malignancies has evolved significantly with continually changing guidelines and treatment options which demand more centralized involvement of radiology than ever before.Radiologists play a pivotal role in interpreting complex cancer scans and guiding clinical teams toward the best management options in the light of clinical profile. Management of complex uro-oncology cases is often discussed in multidisciplinary meetings which are essential checkpoints to evaluate an overall picture and formulate optimal treatment plans.The aim of this article is to provide a radiological perspective with practical guidance to fellow radiologists participating in uro-oncology multidisciplinary meetings based on commonly encountered case scenarios, updated guidelines, and cancer pathways.Crucial imaging tips with regards to renal and urinary tract cancers, upon which therapeutic decisions are made, have been condensed in this article after reviewing several complex cases from urology multidisciplinary meetings and European Association of Urology guidelines.Outline of various diagnostic and management strategies, key staging features, surveillance guidelines, and, above all, what the onco-urologists want to know from radiologists have been succinctly discussed in this article.
Endocrine Therapy of Adult Gender-Incongruent Individuals Seeking Gender Reaffirmation
Authors: Majumder Anirban 
Published: July 2022

AbstractGender-affirming hormone therapy (GAHT) is integral to the management of gender-incongruent (GI) individuals. GAHT greatly improves the quality of life for GI individuals. Current research about outcomes of GAHT and adverse events in adults receiving GAHT is limited in India and large cohort studies are absent. This document on medical management provides protocols for the prescribing clinician relating to counseling for GAHT, baseline evaluation, choice of therapy, targets for hormone therapy, clinical and biochemical monitoring, and perioperative hormone therapy.
Prevalence of Cervical Spondylosis among Cases with Vertigo in a Tertiary Care Center
Authors: S. Prabakaran , A. Raghvi , V. Roselin , RB Namasivaya Navin , S. Rajasekaran 
Published: July 2022

Abstract
Introduction Etiology of vertigo is wide and each etiological factor should be treated accordingly. This study was conducted to assess the prevalence of cervical spondylosis among the cases with vertigo and to assess the clinical factors associated with it.
Materials and Methods A hospital-based cross-sectional study was conducted among cases with vertigo attending the outpatient department of otorhinolaryngology at Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India, during the months of November 2020 to March 2021. A total of 180 cases with vertigo and 180 controls without vertigo were included in the study. Primary outcome assessed was the prevalence of cervical spondylosis among cases with vertigo and the secondary outcome was to assess the clinical characteristics of the study participants and factors associated with the presence of cervical spondylosis. Analysis was done using SPSS version 20.
Results Majority of participants belong to 51 to 55 years of age with slight female predominance. Impacted cerumen auris, otitis media, and perforated tympanic membrane were noted in 19.4, 10, and 10.6% of cases, respectively. Prevalence of cervical spondylosis was reported as 17.2%, and 12.2% of cases had abnormal pure-tone audiometry findings with significant association between the presences of cervical spondylosis.
Conclusion Assessment of hearing using pure-tone audiometry can be done as a routine practice for all the cases with vertigo which occurs due to cervical spondylosis.
Biosynthesis of 3-thia-α-amino acids on a carrier peptide
Authors: Yu Yue , van der Donk Wilfred A. 
Published: July 2022

A subset of natural products, such as polyketides and nonribosomal peptides, is biosynthesized while tethered to a carrier peptide via a thioester linkage. Recently, we reported that the biosyntheses of 3-thiaglutamate and ammosamide, single amino acid–derived natural products, employ a very different type of carrier peptide to which the biosynthetic intermediates are bound via an amide linkage. During their biosyntheses, a peptide aminoacyl-transfer ribonucleic acid (tRNA) ligase (PEARL) first loads an amino acid to the C terminus of the carrier peptide for subsequent modification by other enzymes. Proteolytic removal of the modified C-terminal amino acid yields the mature product. We termed natural products that are biosynthesized using such pathways pearlins. To investigate the diversity of pearlins, in this study we experimentally characterized another PEARL-encoding biosynthetic gene cluster (BGC) from
Tistrella mobilis
(
tmo
). The enzymes encoded in the
tmo
BGC transformed cysteine into 3-thiahomoleucine both in vitro and in
Escherichia coli
. During this process, a cobalamin-dependent radical
S-
adenosylmethionine (SAM) enzyme catalyzes
C
-isopropylation. This work illustrates that the biosynthesis of amino acid–derived natural products on a carrier peptide is a widespread strategy in nature and expands the spectrum of thiahemiaminal analogs of amino acids that may serve a broader, currently unknown function.
Filling and emptying a tank of liquid
Authors: Otto Johann , Mungan Carl E 
Published: July 2022

Abstract
A right cylindrical tank open to the atmosphere is being filled by a laminar jet of incompressible inviscid liquid falling onto its free surface. At the same time, fluid is escaping through a hole centered in the bottom of the tank. Newton’s second law for variable mass and the unsteady Bernoulli equation are combined to find the time dependence of the liquid height in the tank. The level of analysis is suitable for an introductory undergraduate course in fluid dynamics.
The 2022 Plasma Roadmap: low temperature plasma science and technology
Authors: Adamovich I , Agarwal S , Ahedo E , Alves L L , Baalrud S , Babaeva N , Bogaerts A , Bourdon A , Bruggeman P J , Canal C , Choi E H , Coulombe S , Donkó Z , Graves D B , Hamaguchi S , Hegemann D , Hori M , Kim H-H , Kroesen G M W , Kushner M J , Laricchiuta A , Li X , Magin T E , Mededovic Thagard S , Miller V , Murphy A B , Oehrlein G S , Puac N , Sankaran R M , Samukawa S , Shiratani M , Šimek M , Tarasenko N , Terashima K , Thomas Jr E , Trieschmann J , Tsikata S , Turner M M , van der Walt I J , van de Sanden M C M , von Woedtke T 
Published: July 2022

Abstract
The 2022 Roadmap is the next update in the series of Plasma Roadmaps published by Journal of Physics D with the intent to identify important outstanding challenges in the field of low-temperature plasma (LTP) physics and technology. The format of the Roadmap is the same as the previous Roadmaps representing the visions of 41 leading experts representing 21 countries and five continents in the various sub-fields of LTP science and technology. In recognition of the evolution in the field, several new topics have been introduced or given more prominence. These new topics and emphasis highlight increased interests in plasma-enabled additive manufacturing, soft materials, electrification of chemical conversions, plasma propulsion, extreme plasma regimes, plasmas in hypersonics, data-driven plasma science and technology and the contribution of LTP to combat COVID-19. In the last few decades, LTP science and technology has made a tremendously positive impact on our society. It is our hope that this roadmap will help continue this excellent track record over the next 5–10 years.
The surface flashover process under positive lightning impulse voltage: initial stage and evolution
Authors: Meng Yang , Xuan Haorui , Deng Zichen , Li Zhichuang , Ding Weidong , Liu Wen 
Published: July 2022

Abstract
Surface flashover is a crucial issue in the field of electrical insulation, and it involves many complex physical processes. In this paper, the development process of the surface flashover was studied from different methods. The initial process of positive surface streamers in different gas environments (air, N2, CO2) was studied by photoelectric observation. The evolution of positive surface streamers in the air was described based on a 2D fluid model. The influence of the surface trap energy level on flashover development and the relationship between gas adsorption and surface trap energy level was discussed by density functional theory calculation preliminarily. The results showed that the initial ionization process of surface flashover is considered as the collision ionization between the initial electrons and gas molecules and photoionization of high-energy photons. Some of the high-energy photons can not only ionize some gas molecules but also cause the surface of the insulator to emit electrons (photoemission process), which could promote the development of the streamer. Both the ionization of the gas molecules and the photoelectric emission of the insulator surface may determine the initial development of surface flashover. During the process of the flashover, the electron density of the surface streamer (∼1021 m−3) is high and the main streamer tends to develop towards the insulator surface. The attraction of surface streamers changes with the position of the initial electron, and the positive surface charge brings the stronger ionization process, and the negative surface charge has the opposite effect. The band gap of the insulator surface is affected by the adsorption of gas molecules, which is considered as introducing shallow traps on the surface. For impulse voltage, the charge accumulation and internal charge migration may be not evident, the initial photoionization process and initial surface charge distribution affect the flashover process primarily.
Revisiting the Kittel’s model of antiferroelectricity: phase diagrams, hysteresis loops and electrocaloric effect
Authors: Lum C Y , Lim K-G , Chew K-H 
Published: July 2022

Abstract
We revisit the Kittel’s model of antiferroelectricity by extending the model to study the phase transitions, hysteresis loop behaviors and electrocaloric effect (ECE) of antiferroelectrics (AFEs). By considering both the first- and second-order AFEs, explicit expressions for the physical and staggered polarizations of AFEs in the stable states are derived. We also obtain the analytical solutions for describing the dielectric susceptibilities of AFEs in the AFE and paraelectric (PE) phases. Coercive fields in AFE are also derived and studied. To verify the usefulness of the Kittel’s model of antiferroelectricity, we apply the model to systematically investigate the phase transitions, hysteresis loops and ECEs of PbZrO3 (PZO). By adopting appropriate values of the Kittel’s parameters for first-order transition, analytical and numerical results are obtained and discussed. Our results show that PZO exhibits a complex temperature (T)—electric field (E) phase diagram, consisting of the AFE, ferroelectrics, ferrielectric, PE and mixed phases. The T-E phase diagram is qualitatively agreed with the new AFE model that was derived based on symmetry by Tolédano and Khalyavin (2019 Phys. Rev. B 99 024105). We found that the calculated zero-field dielectric susceptibility is qualitatively and quantitatively agreed with experimental results. We show that the polarizations and dielectric susceptibilities of PZO in heating and cooling deviate from each other, as expected for the first-order materials. Our calculated results also reveal that the ECE in PZO has an electro-heating of ΔT ≈ +6.5 °C and an electro-cooling of ΔT ≈ −4.0 °C, respectively, which are comparable to the experimental results.
Enhanced d-wave pairing in the two-dimensional Hubbard model with periodically modulated hopping amplitudes
Authors: Yang Shuhui , Liu Xingcan , Li Weiqi , Yang Jianqun , Ying Tao , Li Xingji , Sun Xiudong 
Published: July 2022

Abstract
Utilizing determinant quantum Monte Carlo algorithm, the evolution of the d-wave pairing in the Hubbard model on the square lattice tuned by the periodically modulated hopping amplitudes is studied. The hopping amplitudes are homogeneous in the

x
ˆ

-direction, while in the

y
ˆ

-direction the hopping amplitudes are modulated with period P, where

t
y

=
t
+
d
t

,

t
y

′

=
t
−
(
P
−
1
)
d
t

, and the modulation period P equals 2, 3 and 4 lattice spacings. The latter two modulation periods are motivated by the observation of period-3 and period-4 stripe order in cuprate superconductors. For all the periods P, we find that the modulated hopping inhomogeneity enhances the d-wave pairing and an optimal inhomogeneity exists.
Structural phase-field crystal model for Lennard–Jones pair interaction potential
Authors: Ankudinov V 
Published: July 2022

AbstractA modification of the structural phase-field crystal model for a Lennard–Jones (LJ) pair interaction potential is presented. Formation of 1D and 2D structures for the LJ-potential was studied numerically. The equilibrium lattice parameters for the obtained structures were found consistent to the correspondent LJ-distance parameters. The lattice parameter of 2D triangle’s structure matches the periodical in 1D, which is consistent to the theory of freezing from the isotropic liquids. Numerically obtained phase diagram of two-dimensional structures qualitatively reproduces classical PFC diagram and coincides with the melting region of high-temperature part of LJ diagram.
Infinity, self-similarity, and continued fractions in physics: applications to resistor network puzzles
Authors: Bissell J J , Nagaitis A M 
Published: July 2022

Abstract
Puzzles involving infinite networks of resistors are an engaging way for students to explore the idea of infinity and self-similarity in physics. Recently K Atkin has described one such puzzle, alongside a solution based on an equivalent finite network (2022 Phys. Educ.
57 025015). Here we present a generalisation of this problem which showcases an important perspective on infinity as the limit of a process, and an alternative method of solution using continued fractions. We illustrate how our method can be used to devise new network puzzles suitable for class challenge problems.