bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review of clinical drug development activities for neuroblastoma from 2011 to 2020
Authors: Nader Jaclynne H. , Bourgeois Florence , Bagatell Rochelle , Moreno Lucas , Pearson Andrew D. J. , DuBois Steven G. 
Published: December 2022

AbstractBackgroundUnderstanding the landscape of clinical trials for patients with neuroblastoma may inform efforts to improve drug development.ProcedureWe evaluated therapeutic trials for patients with neuroblastoma from 2011 to 2020 in our search using clinical trial information from ClinicalTrials.gov, Clinicaltrialregister.eu, PubMed, and American Society of Clinical Oncology (ASCO) annual meeting collection. Trends in trials and treatments over time were evaluated qualitatively.ResultsA total of 192 trials met inclusion criteria. A median of 20.5 trials were started per year, which was stable over time. There were 87 (45%) phase 1, 100 (51%) phase 2, and only five (2.6%) phase 3 trials. The median time to completion was 4.9 years for phase 1 and 2 trials (no phase 3 trials reported as completed during the study period). In all, 34% of trials were international, while 20% of trials were intercontinental. Eighty‐nine percent of nonmyeloablative trials included at least one novel agent. 48% of these trials studied combination therapies, and 86% of these combinations included conventional chemotherapy. Among 157 trials that included a targeted agent, 78 targets were identified, with GD2 being the primary target under investigation in 16.7% of these trials. Only eight trials were included in regulatory decisions, which led to European Medicines Agency (EMA) or Food and Drug Administration (FDA) approval for neuroblastoma.ConclusionsThe large number of trials initiated per year, the range of targets, and the rate of intercontinental collaboration are encouraging. The paucity of late‐stage trials, the prolonged trial duration, and relative lack of combination studies are major causes of concern. This work will inform future drug development for neuroblastoma.
Does the construction retrieval account apply to cross‐modal inhibition of return in semantic context?
Authors: Zu Guangyao , Zhang Tianyang , Yang Jiajia , Wang Aijun , Zhang Ming 
Published: December 2022

AbstractThe traditional attentional reorienting hypothesis is insufficient to explain spatial and nonspatial inhibition of return (IOR). Therefore, a construction retrieval account that includes the influence of top‐down attentional sets has been proposed and can explain both spatial and nonspatial IOR. However, it remains unknown whether the construction retrieval account can be applied to non‐surface features of stimuli, as well as whether its construction and retrieval mechanisms are supra‐modal. The present study manipulated semantic feature congruency and spatial location congruency between the prime and the target in cross‐modal audio‐visual and visual‐audio experimental conditions, respectively, by orthogonally combining spatial and nonspatial IOR paradigms. Our results showed that there was an interaction between semantic feature congruency and spatial location congruency controlled by the attentional sets, and that this interaction was consistent in cross‐modal audio‐visual and visual‐audio conditions. These results suggest that the construction retrieval account can be applied to abstract semantic features and that its construction and retrieval mechanisms are supra‐modal. The present study extends the application scope of the construction retrieval account and promotes the interpretation of IOR under a unified theoretical framework.
Effects of the HORS‐PISTE universal anxiety prevention program measured according to initial level of student problems
Authors: Therriault Danyka , Lane Julie , Houle Andrée‐Anne , Dupuis Audrey , Gosselin Patrick , Thibault Isabelle , Dionne Patricia , Morin Pascale , Dufour Magali 
Published: December 2022

AbstractAnxiety disorders are among the most prevalent psychopathologies in Western adolescents and have been on the rise in recent years. Not only does anxiety disrupt the daily lives of the young people who suffer from it, it can also have harmful behavioral, psychological, social, and academic effects. Given this, there is a pressing need to implement universal anxiety prevention programs for adolescents in one of their main living environments, the school. This type of program has the twofold advantage of reaching all adolescents before the onset of more significant symptoms and of promoting access to services for young people in difficulty. This study aimed to evaluate the effects of the HORS‐PISTE—Exploration Cycle 1 program developed by the RBC Center for Academic Expertise in Mental Health, based on the initial level of problems presented by the students, using a preexperimental pretest–posttest design. A total of 2276 students in grades 7 and 8, with an average age of 12.65 years, from 16 high schools participated in the pretest and posttest evaluations. The results showed that the students who participated in the HORS‐PISTE program reported a significant change in the intended direction for several of the variables examined between T1 and T2. In particular, decreases in anxiety symptoms, fear of being judged by others, perfectionism, internet addiction, intolerance of uncertainty, and anxiety interference, as well as an increase in the sense of self‐efficacy, were observed between T1 and T2 for both boys and girls. The results also showed that students who presented at T1 with more significant anxiety symptoms and proximal risk factors experienced greater improvement than did those with a moderate or low level of initial problems. Overall, the results of this evaluative study of the HORS‐PISTE program are promising, demonstrating positive changes in symptoms and in the main proximal risk factors for anxiety, in particular among students who initially presented with high levels of problems. This study therefore demonstrates the relevance of implementing this type of prevention program in high schools.
Investigation of the relationships between ADHD risk and digital screen exposure in children aged 4–11: A large population study in Turkey
Authors: Gunuc Selim 
Published: December 2022

AbstractThis study investigated whether some factors regarding especially pregnancy and post‐pregnancy and 0–36‐month‐old infants’ exposure to digital screens played a role in the attention deficit hyperactivity disorder (ADHD) scores of 4–11‐year‐old children. The cross‐sectional research method was used. The sample consisted of the mothers of 2835 (48.2%) daughters and 3042 (51.8%) sons. The children of the mothers in the sample were between 4 and 11 years old. The mothers were asked to fill in the personal information form about their children and the Conners Parent Rating Scale to determine the ADHD score of the child. The main results revealed associations between ADHD and digital screen exposure at 0–36 months. In conclusion, exposure to digital screen—whether much or little—for the purposes of feeding, silencing, distraction, language acquisition, and digital gaming might pose a serious risk for ADHD.
Sport participation among children with complicated mild traumatic brain injury
Authors: Hansen Colby , Teramoto Masaru , Gardner James E. , Capizzi Allison N. 
Published: December 2022

AbstractBackgroundComplicated mild traumatic brain injury (C‐mTBI) represents mTBI with positive trauma‐related radiographic findings, such as hematoma. It is estimated that 7.5% of all pediatric mTBIs meet these criteria. There is a paucity of research on return to sports in children with C‐mTBI.ObjectiveTo examine children with C‐mTBI, mTBI with skull fracture (mTBI‐SF) only and mTBI in relation to sport participation and factors associated with repeated injury.DesignCross‐sectional survey.SettingLevel I pediatric trauma center.ParticipantsParents of children who were 5–18 years of age at the time of injury who sustained C‐mTBI or mTBI from 2010 to 2013.InterventionsNot applicable.Main Outcome MeasuresSports participation characteristics before and after injury in children with C‐mTBI and mTBI as a function of degree and length of recovery. Repeat mTBI after the index injury was also examined.ResultsOf 247 children who participated in sports preinjury (27.5% with C‐mTBI and 9.7% with mTBI‐SF), 95.1% returned to sports. There was no significant difference by mTBI type regarding participation in any sports (p = .811) nor with high‐risk sports (p = .128). C‐mTBI but not mTBI‐SF (versus mTBI) was associated with lower odds of sustaining a repeat mTBI (odds ratio = 0.30, p = .045). Waiting longer (>3 months compared to <1 month) to return to contact sports was associated with lower odds of sustaining a repeat mTBI (odds ratio = 0.23, p < .05).ConclusionsChildren with C‐mTBI and mTBI‐SF resume similar sports as children with mTBI. Those with C‐mTBI and those who take longer to return to play may have lower risk of repeat mTBIs. Prospective research is needed to inform the development of evidence‐based guidelines for children with C‐mTBI and mTBI‐SF.
Stable isotope characterisation of 3,4‐methylenedioxyphenyl‐2‐propanone and 3,4‐methylenedioxyamphetamine prepared from piperonal
Authors: Cormick Justin , Carter James F. , Currie Timothy , Matheson Carney , Cresswell Sarah L. 
Published: December 2022

RationaleStable isotopic ratios can provide information for illicit drug profiling. The research presented here investigated the variations in stable isotopic ratios of hydrogen (δ2H), carbon (δ13C), nitrogen (δ15N) and oxygen (δ18O) during the synthesis of MDP2P (3,4‐methylenedioxyphenyl‐2‐propanone) and MDA (3,4‐methylenedioxyamphetamine) prepared via the ‘nitrostyrene’ route.MethodsSamples of MDA and MDP2P were synthesised from two isotopically characterised starting materials, piperonal and nitroethane. The isotopic compositions of the nitrostyrene intermediate (3,4‐methylenedioxyphenyl‐2‐nitropropene, MDP2NP) and products MDP2P and MDA were also measured by isotope ratio mass spectrometry.ResultsA significantly negative change occurred to δ2H values during the production of MDP2NP, MDP2P and MDA, indicating a mechanism that favours inclusion or retention of 1H over 2H. This suggests that the δ2H compositions of MDA/MDP2P prepared from piperonal will not provide information on the synthetic history. Minimal changes were observed in δ13C composition during the synthesis of MDP2NP, MDP2P and MDA, and minimal δ15N compositional changes occurred in MDP2NP and MDA. Progressing from piperonal to MDP2NP, a minimal change occurred to δ18O composition. A variable change to δ18O was observed from MDP2NP with one sample becoming more positive in δ18O composition and two samples becoming more negative. Progressing from MDP2NP to MDA, a significant negative change occurred to δ18O composition.ConclusionsThe changes to stable isotopic ratios observed during the preparation of MDA and MDP2P from piperonal may prove useful when attempting to compare batch‐to‐batch variations between seizures and provide information with tactical intelligence applications.
Neural network based adaptive control for a piezoelectric actuator with model uncertainty and unknown external disturbance
Authors: Wu Yinan , Chen He , Sun Ning , Fan Zhi , Fang Yongchun 
Published: December 2022

AbstractTo lessen the positioning error of the piezoelectric actuator (PEA) caused by hysteresis nonlinearity and unknown external disturbance, a neural network based adaptive controller is designed to realize the accurate trajectory tracking of the PEA. Specifically, a more universal model, consisting of a hysteresis submodel and a dynamics submodel, is first built for the PEA without the requirement of parameter identification. On this basis, a sliding mode adaptive controller capable of handling unknown parameters of the dynamics submodel is designed to weaken the damage of external disturbance to the system stability. Furthermore, to deal with the hysteresis submodel with unknown structure and parameters, a neural network based self‐tuning control scheme is developed to enable the PEA to accurately track the desired trajectory. Moreover, Lyapunov stability analysis is performed to strictly prove that the tracking error of the system can asymptotically converge to zero. Finally, the performance of the designed controller is verified via sufficient comparative simulations and experiments.
Effect of Preload Force on the Performance of Dual‐Electrolyte Li‐Air Batteries
Authors: Zhai Yanrui , Li Jie , Zhang Tianyu , Luan Lihua , Wang Yuyang , Liu Qianhe , Yu Minfu , Sun Hong 
Published: December 2022

AbstractIn this paper, a two‐dimensional macroscopic element model was established for dual‐electrolyte Li‐air batteries (LABs) by COMSOL Multiphysics. The model combined Structural Mechanics module, Lithium‐Ion Battery (liion), Transport of Diluted Species in Porous Media (tds) and Ordinary Differential Equations (ODEs) and Differential Algebraic Equations (DAEs) at the transient condition. It is illustrated that the porosity of the battery is the maximum, the transmission performance of O2 and Li+ is the best, the discharge specific capacity is 2044 mAh ⋅ g−1. The over‐potential is the minimum when 0.5 MPa preload force is applied to the dual‐electrolyte LABs in the range of 0–2 MPa according to the numerical simulation. Moreover, the effect of the best preload force of 0.5 MPa during the process of the experiment is substantiated.
Synthesis of Polymer Electrolyte Membranes from Sulfonated Poly(Arylene Ether Ketones) with Partial Substitution of Carboxylate Acid Group
Authors: Aziz Abdul , Lotebulo Ndruru Sun Theo Constan , Bundjali Bunbun , Wahyuningrum Deana , Arcana I Made 
Published: December 2022

AbstractChemical modification of Sulfonated poly(arylene ether ketone) with carboxylate acid side chain (C‐SPAEK) membranes has been conducted through partially substitution of the 4,4‐bis(4‐hydroxyphenyl)‐valeric acid (DPA) with 4,4‐bis(4‐hydroxyphenyl)‐propane (BPA) at varies different compositions of sulfonate. FTIR and EDS analysis of the synthesized SPAEK revealed the presence of carboxylic acid, methyl, sulfonate groups and aromatic ether bonds in the SPAEK membrane. The effect of different compositions of carboxylic acid and sulfonate groups on mechanical strength, thermal stability, oxidative stability, water absorption, swelling ratio and proton conductivity of the membranes was studied. The SPAEK‐50/50 membrane exhibits superior properties with high mechanical strength, high thermal and oxidative stability, good water absorption, low swelling ratio, high dimensional stability and has a proton conductivity at 80 °C of 0.102 S/cm close to the Nafion‐117 membrane of 0.120 S/cm. This finding confirms that the partial substitution of the hydrophilic monomer of DPA with 50 % mole of BPA with a sulfonate group composition of 50 % resulted in an excellent SPAEK membrane.
Applications ofPeristrophe paniculataDerived Plasmonic Nanoparticles for DNA Binding and Photocatalytic Degradation of Cationic Dyes
Authors: Devi Thangavel Akkini , Velammal Subramanian Priya , Jeba Devadason Princess , Amaladhas Thomas Peter 
Published: December 2022

AbstractResearch on plasmonics and their applications in diverse fields has increased significantly over the last decade. The present work primarily aimed to bio‐fabricate silver and gold plasmonic nanoparticles and to study their potential as photocatalysts and as DNA binders. To achieve this, Ag and Au NPs were derived employingPeristrophe paniculataand their optical, morphological and structural properties were investigated by standard analytical techniques. The formation rate constant k was 2.58×10−2 min−1and 3.56×10−2 min−1for Ag and Au NPs correspondingly. FT‐IR analysis showed that the water‐soluble alkaloid, 5‐amino‐3,4‐dihydro‐2H‐pyrrole‐2‐carbonitrile was responsible for the stabilization of nanoparticles. Transmission electron microscopic studies disclosed the formation of uniform spherical AgNPs and irregularly shaped AuNPs and the diameter was 9.32 nm and 27.85 nm respectively which was again corroborated by XRD studies (16.64 nm and 36.08 nm). The interaction of ct‐DNA with Ag and Au NPs was investigated using absorption spectroscopy in the UV‐Vis range and the binding constant values were 2.2×105 M−1and 8.1×106 M−1respectively. The degradation of methylene blue and malachite green by AgNPs was almost 100 % and 65 % respectively in 3 h under sunlight and neutral pH (pseudo first order rate constants were 7.9×10−3 min−1and 1.9×10−3 min−1). Moreover, the derived AgNPs exhibited mitigate activity against targeted pathogens. Thus, this green technique could be implicit for the eco‐friendly synthesis of Ag and Au NPs, and the prepared nanoparticles may be explored as photocatalysts for the degradation of cationic dyes without any added oxidants.
Novel synergistic Combination of W and Co Co‐doped ZnO Nanoparticles Incorporated as a Photoanode in a Dye Sensitized Solar Cell
Authors: Chundawat Priyanka , Vyas Yogeshwari , Dharmendra Dharmendra , Chaubisa Purnima , Ameta Chetna 
Published: December 2022

AbstractIn this study, a low‐cost and simple Sol‐gel technique has been used for the synthesis of W/Co co‐doped ZnO nanoparticles. XRD examinations demonstrate the hexagonal wurtzite structure. To investigate the morphology of ZnO nanoparticles was demonstrated by using SEM and TEM. EDS and FTIR spectra verify the triumphant doping of the W and Co into the ZnO lattice. The optical measurement shows that as the concentration of Co increases the band gap decreases from 3.2 eV to 2.73 eV. The DSSCs based on 0.5 % W and 1.6 % Co co‐doped ZnO photoanode achieved the highest open‐circuit voltage of 0.69 V having a short circuit current density of 8.46 mAcm−2, and PCE of 3.16 %.
Recent Progress on Biosensors for the Early Detection of Neurological Disorders.
Authors: Chougale Amit , Vedante Shruti , Kulkarni Guruprasad , Patnawar Sneha 
Published: December 2022

AbstractNeurological disorders are a point of attraction these days due to their physical, mental, and genetic threat to human beings. The researchers are refining the therapeutics and striving to eradicate the life‐threatening burden of chronic diseases by upsurging and proposing advanced instrumentation. There are a number of neurological diseases that cause alterations in the genetic sequences due to pathogenic or self‐negligence. According to the WHO, stroke, septicemia, PD, epilepsy, and MS are found to be the deadliest and most invading among millions of people. Various diagnostic methods are employed for monitoring these disorders in the human body at an early stage, in process of cure. The current review highlights the strengths of several advanced detection devices, such as biosensors to identify and quantify biomarkers, some sensing gadgets, and other genetic tactics or innovations to ameliorate traditional protocols. Furthermore, the meticulous description of ongoing experiments with the help of relevant case studies of neurodegenerative disorders supports the impact and vitality of advanced equipment. Further, the necessity of biosensors in distinct disorders to aid in an early diagnosis, and the influence of nano‐based materials in preparation is emphasized. Finally, several issues that should be addressed in upcoming decades with the steep rise in analytical technology have been discussed.
Small‐Molecule Fluorescent Probe: Ratiometric and Selective Detection of Sodium Ions for Imaging and Solid‐State Sensing Applications
Authors: Ananthan Karthick Kettalu , Shankar Bhaskaran , Kubendran Aravind Manikka , Ashokkumar Balasubramaniem , Tamilselvi Arunachalam 
Published: December 2022

AbstractA ratiometric highly fluorescent small molecular probe (L), 1,2,4‐triazol‐4‐yliminomethyl‐5‐(hydroxymethyl)‐2‐methylpyridin‐3‐ol, was designed for detecting Na(I) ions in DMF:water (1 : 9, v/v) medium. The chemical structure of Na(I) complex of probe was confirmed by single crystal XRD. The fluorescence detection of Na+ ion has been executed in both solid and solution medium. The observations suggest the same chemical structure in solution state as well. The detailed photochemical studies showed that highly selective sensing of Na+ ions even in the presence of common interfering K+ ions. The fluorescence decay studies showed that the lifetime of NaL is lesser than L. The excited state intramolecular proton transfer (ESIPT) mechanism and the nature of electronic transitions were examined by quantum chemical studies. The electrochemical behaviour was studied by cyclic voltammetry and impedance spectra. It has also been shown that the probe can be applied to paper based sensing and imaging of Na+ ions in U87 cell lines.
Decoding Solvent Polarity Related Excited State Behaviors for the Novel Amino NH‐type 3TfAPI Fluorophore
Authors: Zhao Jinfeng , Jin Bing , Dong Hao 
Published: December 2022

AbstractIn this work, we mainly pay attention to solvent polarity dependent excited state behaviors for amino NH‐type N‐cyclohexylphthalimide‐substituted trifluoroacetylamino (3TfAPI). Based on quantum chemical simulations, infrared (IR) vibrational spectra, atomic charge distributions, and photo‐induced geometrical changes reveal hydrogen bond N−H⋅⋅⋅O should be enhanced in S1. Particularly, enhancement effectiveness of hydrogen bonding with polar polarity solvent is more apparent. Exploring photoexcitation, we find photo‐induced intramolecular charge transfer (ICT) plays critical roles in facilitating ESIPT tendency for 3TfAPI. By constructing potential energy curves (PECs), we clarify detailed ESIPT mechanism for 3TfAPI, but also present solvent polarity regulated ESIPT behavior.
High Electrical Conductivity and Low Temperature Resistant Double Network Hydrogel Ionic Conductor as a Flexible Sensor and Quasi‐Solid Electrolyte
Authors: Ma Xudong , Maimaitiyiming Xieraili 
Published: December 2022

AbstractThe existence of large amounts of water in hydrogel electrolytes makes them inevitably freeze at low temperatures, which causes them to lose properties such as flexibility or electrical conductivity. It limits the application of hydrogel electrolytes at low temperatures. Here, we designed hydrogels with interpenetrating double network structure based on polyacrylamide and agar. By doping a high concentration of LiCl as the conducting material, a continuous ion‐conducting path was formed. The conductivity reached 2.18 S/m at 25 °C and 1.58 S/m at −30 °C. The prepared hydrogel electrolytes exhibit good mechanical and electrochemical properties to meet the needs of different application situations. A wearable sensor with hydrogel electrolytes was demonstrated. The wearable sensor can be attached to a part of the human body and can successfully detect various human movements. The wearable sensors can be used as temperature sensors in addition to detecting motion, which shows an encouraging and powerful utility in wearable electronic devices.
A Novel AIE Fluorescent Probe for Cu2+ Recognition Based on Salicylaldehyde‐azine System
Authors: Liu Jie , Leng Chengrang , Chen Quanan , Liang Qirui , Li Chenhao , Li Shuo , Zhang Zhen , Xiao Lufei 
Published: December 2022

AbstractA novel compound, obtained by one‐step condensation of salicylaldehyde and hydrazine hydrate, has been synthesized, and characterized by various spectroscopic techniques. The crystal structure and photophysical properties of the compound have been analyzed in detail. The compound exhibits distinct aggregation‐induced emission in acetonitrile‐water, and high selectivity towards Cu2+ ions, fast response time, and low detection limit (5.7×10−7 mol/L). In this sense, the compound can be applied as a potential probe for detecting copper (II) ions.