bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daprodustat Accelerates High Phosphate-Induced Calcification Through the Activation of HIF-1 Signaling
Authors: Tóth Andrea , Csiki Dávid Máté , Nagy Béla , Balogh Enikő , Lente Gréta , Ababneh Haneen , Szöőr Árpád , Jeney Viktória 
Published: February 2022

Aims: Chronic kidney disease (CKD) is frequently associated with other chronic diseases including anemia. Daprodustat (DPD) is a prolyl hydroxylase inhibitor, a member of a family of those new generation drugs that increase erythropoiesis via activation of the hypoxia-inducible factor 1 (HIF-1) pathway. Previous studies showed that HIF-1 activation is ultimately linked to acceleration of vascular calcification. We aimed to investigate the effect of DPD on high phosphate-induced calcification.Methods and Results: We investigated the effect of DPD on calcification in primary human aortic vascular smooth muscle cells (VSMCs), in mouse aorta rings, and an adenine and high phosphate-induced CKD murine model. DPD stabilized HIF-1α and HIF-2α and activated the HIF-1 pathway in VSMCs. Treatment with DPD increased phosphate-induced calcification in cultured VSMCs and murine aorta rings. Oral administration of DPD to adenine and high phosphate-induced CKD mice corrected anemia but increased aortic calcification as assessed by osteosense staining. The inhibition of the transcriptional activity of HIF-1 by chetomin or silencing of HIF-1α attenuated the effect of DPD on VSMC calcification.Conclusion: Clinical studies with a long follow-up period are needed to evaluate the possible risk of sustained activation of HIF-1 by DPD in accelerating medial calcification in CKD patients with hyperphosphatemia.
Inductively-Coupled Plasma Mass Spectrometry–Novel Insights From an Old Technology Into Stressed Red Blood Cell Physiology
Authors: Stephenson Daniel , Nemkov Travis , Qadri Syed M. , Sheffield William P. , D’Alessandro Angelo 
Published: February 2022

BackgroundIon and metal homeostasis are critical to red blood cell physiology and Inductively Coupled Plasma (ICP) is a decades old approach to pursue elemental analysis. Recent evolution of ICP has resulted in its coupling to mass spectrometry (MS) instead of atomic absorption/emission.MethodsHere we performed Inductively-coupled plasma mass spectrometry (ICP-MS) measurements of intra- and extra-cellular Na, K, Ca, Mg, Fe, and Cu in red blood cells undergoing ionic, heat, or starvation stress. Results were correlated with Ca measurements from other common platforms (e.g., fluorescence-based approaches) and extensive measurements of red blood cell metabolism.ResultsAll stresses induced significant intra- and extracellular alterations of all measured elements. In particular, ionomycin treatment or hypertonic stress significantly impacted intracellular sodium and extracellular potassium and magnesium levels. Iron efflux was observed as a function of temperatures, with ionic and heat stress at 40°C causing the maximum decrease in intracellular iron pools and increases in the supernatants. Strong positive correlation was observed between calcium measurements via ICP-MS and fluorescence-based approaches. Correlation analyses with metabolomics data showed a strong positive association between extracellular calcium and intracellular sodium or magnesium levels and intracellular glycolysis. Extracellular potassium or iron were positively correlated with free fatty acids (especially mono-, poly-, and highly-unsaturated or odd-chain fatty acid products of lipid peroxidation). Intracellular iron was instead positively correlated with saturated fatty acids (palmitate, stearate) and negatively with methionine metabolism (methionine, S-adenosylmethionine), phosphatidylserine exposure and glycolysis.ConclusionIn the era of omics approaches, ICP-MS affords a comprehensive characterization of intracellular elements that provide direct insights on red blood cell physiology and represent meaningful covariates for data generated via other omics platforms such as metabolomics.
Impact of Safety Nets on Household Coping Mechanisms for COVID-19 Pandemic in Malawi
Authors: Mnyanga Martha , Chirwa Gowokani Chijere , Munthali Spy 
Published: February 2022

BackgroundCovid-19 pandemic induced various shocks to households in Malawi, many of which were failing to cope. Household coping mechanisms to shocks have an implication on household poverty status and that of a nation as a whole. In order to assist households to respond to the pandemic-induced shocks positively, the government of Malawi, with support from non-governmental organizations introduced Covid-19 Urban Cash Intervention (CUCI) and other safety nets to complement the existing social protection programs in cushioning the impact of the shocks during the pandemic. With these programmes in place, there is a need for evidence regarding how the safety nets are affecting coping. Therefore, this paper investigated the impact that safety nets during Covid-19 pandemic had on the following household coping mechanisms: engaging in additional income-generating activities, receiving assistance from friends and family; reducing food consumption; relying on savings; and failure to cope.MethodsThe study used a nationally representative panel data from the Malawi High Frequency Phone Survey on Covid-19 (HFPS Covid-19) and complemented it with the fifth Integrated Household Panel Survey (IHPS), also known as living standards measurement survey. Five Random Effects Probit Models were estimated, one for each coping mechanism.ResultsFindings from this study indicated that beneficiaries of safety net programs were more likely to rely on remittances from friends and family than the people who had no safety nets. Furthermore, the safety net recipients were less likely to reduce food consumption or rely on savings than the non-recipients. Despite the interesting findings, we also noticed that safety nets had no significant impact on household engagement in other income-generating activities in response to shocks.ConclusionThe results imply that safety nets in Malawi during the Covid-19 pandemic had a positive impact on consumption and prevented the dissolving of savings. Therefore, these programs have to be scaled up, and the volumes be revised upwards.
MINERAL AND VITAMIN NUTRITION OF HIGHLY PRODUCTIVE HOLSTEIN-KHOLMOGORY COWS IN THE POLAR REGION
Authors: КУЗЬМИНА Л.Н. , КАРТАШОВА А.П. 
Published: February 2022

Разработан минерально-витаминный премикс на основе природного цеолита — вермикулита для коров с удоем 7—9 тыс. кг молока в период сухостоя, I, II и III фазы лактации. В состав вермикулита входит большой набор микро- и макроэлементов, таких как медь, цинк, марганец, кобальт, кремний, являющихся ценными минеральными добавками. Изучено влияние премиксов с различным содержанием вермикулита на переваримость питательных веществ рациона, усвоение минеральных элементов, использование животными азота из рациона, их продуктивность. Опыт проведен на коровах в течение лактации и сухостойного периода. В результате проведенных исследований установлено, что минерально-витаминные премиксы, содержащие 1,5—5,0% вермикулита от сухого вещества рациона, способствовали регуляции выведения и отложения минеральных веществ, лучшему использованию азота и перевариванию питательных веществ в организме коров. При этом стабилизируется физиологическое состояние животных, увеличивается содержание жира в молоке коров на 0,09 абс. процентов, повышается продуктивность 4%-ного молока на 8,2%, расход кормов на 1 кг молока снижается до 4,9%.
A mineral-vitamin premix based on natural zeolite — vermiculite has been developed for cows with milk yield 7—9 thousand kg during the dry period, I, II, and III phases of lactation. Vermiculite contains a large set of micro and macro elements such as copper, zinc, manganese, cobalt, silicon, which are valuable mineral additives. It is studied the effect of premix with different content of vermiculite on the digestibility of nutrients in the ration, the assimilation of mineral elements, the use of nitrogen by animals from the ration, and their productivity. The experiment was carried out on cows during the entire lactation and dry period. As a result of the studies, it was found that mineral-vitamin premixes containing vermiculite 1.5—5.0% of the ration dry matter, promoted the regulation of mineral excretion and deposition, the better nitrogen utilization, and the digestion of nutrients by the cows’ body. At the same time, the physiological state of the animals is stabilized, the fat content in the cow milk increases by 0.09 abs. percent, productivity of 4% milk increases by 8.2%, the feed consumption per 1 kg of milk decreases to 4.9%.
SIENTIFIC JUSTIFICATION OF THE OPTIMAL MILK PERFORMANCE IN BLACK-AND-WHITE BREED
Authors: СТРЕКОЗОВ Н.И. , ВИНОГРАДОВ В.Н. , КРЫЛОВА Г.Н. 
Published: February 2022

Рассмотрены вопросы оптимального уровня продуктивности коров черно-пестрой породы при сохранении продуктивного долголетия: раздой животных по 1 лактации, корреляция удоев за 1—8 лактации, влияние отцов и матерей на долголетие коров, потенциал молочной продуктивности матерей быков-производителей. Коровы с более высоким удоем за 1 лактацию имели лучшие удои за 3 и наивысшую лактации. С увеличением продуктивности за 1 лактацию свыше 7000 кг молока число лактаций снижается. Более выравненной продуктивностью за все лактации отличались коровы с удоем от 4000 кг до 7000 кг. Положительное влияние на раздой и пожизненную продуктивность дочерей имела продуктивность матерей. Наиболее высоким уровнем реализации потенциала продуктивности отличались особи с удоем матерей от 4000 кг до 6000 кг за лактацию. Положительная взаимосвязь удоя за лактацию установлена с родительским индексом коровы (0,251) и удоем за 305 дней наивысшей лактации матерей (0,251) и матерей отцов (0,254). Увеличение продуктивности матерей отцов за 305 дней наивысшей лактации способствует росту удоя за наивысшую лактацию дочерей. При этом дочери превосходят матерей по удою за наивысшую лактацию от 291 до 895 кг в среднем на 1 голову в зависимости от класса продуктивности матерей отцов.
The research paper covers issues on the optimal milk performance in cows provided the retention of the production longevity: milk yield in cows per lactation, milk yield correlation for 1 to 8 lactation cycles; the influence of genetic aspects on cow longevity; milk performance in female cows being mothers of male cows. Cows with a higher milk yield per lactation showed a better milk yield per 3 and the highest lactation. When the milk performance per lactation increased 7000 kg, the number of lactation cycles decreases. The most uniform milk performance throughout lactation cycles was shown by cows yielding 4000 to 7000 kg of milk. Milk performance of daughter cows depended on that of their mothers. The highest level of milk performance potential implementation was shown by specimens born by mothers yielding 4000 to 6000 kg per lactation. Positive interrelation of milk yield per lactation with the parent index of cows (0.251) and the milk yield for 305 days of the highest lactation of mother cows (0.251) and mothers of father cows (0.254). An increase in milk performance in mothers of father cows for 305 days of the highest lactation contributes to an increase in milk yield for the highest lactation of daughter cows. At that, daughter cows yield 291 to 895 kg more milk per cow than their mothers for the highest lactation, depending on the milk performance class of mothers of father cows.
PENGARUH OPTIMALISASI PERAN DOKTER GIGI KECIL DALAM DETEKSI GIGI SEJAK DINI (SIGINI) UNTUK MENURUNKAN ANGKA ORAL HYGIENE INDEX SYMPLIFIED (OHI-S)(Penelitian Dilakukan Pada Siswa SD Se Desa Batuan, Kec. Sukawati, Kabupaten Gianyar)
Authors: Gejir I Nyoman , Kencana I Gede Surya , Wirata I Nyoman , Supariani Ni Nyoman Dewi , Swastini I G A A P 
Published: February 2022

To keep the dental and oral cleanliness is one of effort to prevent the dental and oral disease. The objective of this research is to know the influence optimalization role of little dentists in Early Detection of Teeth Program to lower Oral Hygiene Index Simplified score of students in Elementary School in Batuan Villages, Sukawati Sub district, Gianyar Regency in 2019.The research is quasi experimental with pre and post test design. The research will do June 2019. The population in this research is all students in Elementary School in Batuan Villages, Sukawati Sub district, Gianyar Regency. This research use 106 respondents. The data will analyze with paired t-test, to know the influencing of Early Detection of Teeth Program by optimalization role of little dentists to lower Oral Hygiene Index Simplified score of students in Elementary School in Batuan Villages, Sukawati Sub district, Gianyar Regency.The results of this research shows that before optimalization role of little dentists in Early Detection of Teeth Program, majority (80 peoples: 75.4%) students with OHI-S in middle criteria, and there are 3 peoples (2.83%) with poor criteria. After optimalization role of little dentists in Early Detection of Teeth Program, majority (79 peoples: 74.53%) students with OHI-S in good criteria, and there is not with poor criteria. The results of analyze with Paired Samples Test shiows that there is influence optimalization role of little dentists in Early Detection of Teeth Program to lower score of OHI-S with the value of significance lower than 0.005.The conclusion of this study is optimalization role of little dentists in Early Detection of Teeth Program has influence to lower score of OHI-S of students in Elementary School in Batuan Villages, Sukawati Sub district, Gianyar Regency in 2019. Based on the results of this study recommend that all the elementary schools need to train the little dentist.
KORELASI TINGKAT PENDIDIKAN DENGAN TINGKAT PENGETAHUAN TENTANG MENYIKAT GIGI PADA IBU PKK ASRAMA TNI YANG BATU DENPASAR TAHUN 2020
Authors: Swastini I Gusti Ayu Agung Putu , Dharmawati I Gusti Agung Ayu , Dwiastuti Sagung Agung Putri , Raiyanti I G A , Fatimah Siti 
Published: February 2022

Oral health is closely related to behavior. A person's behavior is influenced by knowledge, including knowledge of teeth brushing. Teeth brushing is an action to clean teeth and mouth from food debris which aims to prevent disease in hard and soft tissues. The purpose of this study was to determine the level of knowledge of brushing the teeth of the PKK Indonesian Military Dormitory in Yang Batu Denpasar in 2020. This research is a descriptive study using a survey design. The sample in this study was the mother PKK TNI Dormitory Yang Batu Denpasar, totaling 60 respondents. The research data were analyzed using the Spearman correlation test. Based on the results of the study, the level of knowledge of brushing teeth showed that the percentage of PKK mothers who obtained a good level of knowledge was 19 people (31.67%), 36 people (60%) sufficient criteria and less as many as 5 people (8.33%). The average level of knowledge on brushing the teeth of PKK in the Yang Batu Military Dormitory was 72.16 with sufficient criteria. The conclusion of this research is that most of the PKK women of the TNI Yang Batu Dormitory have a sufficient level of knowledge.
Hubungan Pengetahuan Sikap Dan Tindakan Penggunaan Alat Pelindung Diri Dengan Keluhan Subyektif Karyawan Di Homeindustry Pencelupan Benang
Authors: Sri Supia Anggreni Ni Luh , Bulda Mahayana I Made 
Published: February 2022

Abstract One of yarn dyeing industries located in Sampalan Klod Village, Dawan district, Klungkung regency, is not optimizing protective private equipment for their employees. The purpose of this study is to determine the correlation of knowledge, demeanor, and behavior regarding the use of personal protective equipment toward subjective complaints of employees in the yarn dyeing industry. The type of research used is descriptive analytic research. The design of this study is cross-sectional using the chi-square test. Based on the results, as much as 53.13% of employees have a moderate level of knowledge. The moderate category of employees’ demeanor was 53.13%. The lack behavior of employees was 37.50%. Yarn dyeing industry's employees who experienced subjective complaints were 56.25%. The test results obtained the results of sig 0,000 which is less than 0.05, which means there is a correlation of demeanor, knowledge, and behavior of protective private equipment of employee's subjective complaints at yarn dyeing home industry. Employees are expected to be able to maintain occupational health and safety work, Health Departments are expected to increase employee knowledge of safety work by routinely providing information about the importance of using personal protective equipment.Keywords: Knowledge, attitudes, actions, subjective complaints
Perbaikan Kualitas Kerja Dengan Desain Alat Penopang Kepala Bagi Buruh Suwun Di Pasar Badung Denpasar
Authors: Bulda Mahayana I Made 
Published: February 2022

Abstract : One side of industrialization have followed the progress of science and technology in the formal workers, informal workers the other hand very little attention from the government, such as suwun workers lift transport of goods in the Market Badung, Denpasar. The purpose of research is to identify the workload and subjective complaints suwun workers before and after using the tool supporting head in the Market Badung, Denpasar. This type of research is pre experiment with the same study design subject of a pattern of "One Group Pretest-Posttest Design". Large sample of 14 persons. The results of the research work environment temperatures between 30-32⁰C; 80-87% humidity and wind speed ranges between 10-14 km/h. A decline in the average value of the pulse rate of 5.47% of the workers suwun who use braces head with the tool supporting that do not use the head and there are differences in the pulse of work before and after using the tool supporting head (p 0.05). A decline in the average value of subjective complaints 11.43% suwun workers who use the tool supporting head with do not use the the tool supporting head and there are differences in subjective complaints before and after using the tool supporting head (p 0.05). Conclusion No difference pulse work and subjective complaints suwun workers at Market Badung Denpasar before and after using the tool supporting head. Advice to the parties concerned to continue to disseminate to the workers suwun about the benefits derived from the use of tools supporting the head and the other researchers in order to create a more the tool supporting head inovasif and modern. Keywords : the tool supporting head, workload, subjective complaints
Hubungan Antara Pengetahuan Dan Sikap Dengan Tindakan Petugas Kesehatan Dalam Upaya Pengelolaan Sampah Medis Di Puskesmas Dawan II Tahun 2021
Authors: Widyasari Kadek Ari , Sujaya I Nyoman 
Published: February 2022

Abstract The Public Health is a functional organization unit that organizes health efforts that are comprehensive and integrated, evenly accepted and affordable by the community. The purpose of this study was to determine the relationship between knowledge and attitudes of health workers and actions in efforts to manage medical waste at Dawan II Public Health Center in 2021. This research is a type of quantitative research with a cross sectional approach with a population of all health workers totaling 63 people with the instruments used in the form of questionnaires and observation sheets. The analysis was carried out by univariate and bivariate with the Chi-square test. Based on hypothesis testing, it is known that the knowledge of health workers in efforts to manage medical waste at the health center has a P-Value = 0.001 significance p = 0.05. Meanwhile, the attitude of health workers in the efforts to manage medical waste at the health centers has a P-Value = 0.001 significance p = 0.05. So it can be concluded that there is a relationship between knowledge and attitudes with the actions of health workers in efforts to manage medical waste at Dawan II Public Health Center in 2021. Keywords: Knowledge, Attitude, Medical Waste Management
El diagnóstico psicopedagógico y el comportamiento infantil. Estudio de caso
Authors: Alcívar Chávez Adela Connie 
Published: February 2022

En la actualidad existen problemas de comportamiento en los niños dentro de las aulas escolares, que como experiencia proviene de la formación que reciben de sus padres como educadores. Este estudio parte sobre diagnóstico psicopedagógico y el comportamiento infantil en una Unidad Educativa durante el periodo 2018-2019”, el cual establece la importancia del diagnóstico psicopedagógico en el comportamiento infantil. La metodología fue descriptiva y analítica, se aplicaron registros anecdóticos y escala descriptiva, misma que permitió conocer la problemática planteada. Se presentó una propuesta para mejorar el comportamiento infantil y el área socio afectivo. Los niños con problemas de conducta suelen mostrarse desobedientes, malcriados, berrinchudos y groseros, el diagnóstico psicopedagógico permite conocer las dificultades que se presenten en el comportamiento de los pequeños desde edades tempranas, buscar una solución para evitarlas y utilizar estrategias metodológicas acordes a sus diferencias individuales, al entorno social, realidad socioeconómica y la creatividad del docente.
Adaptación familiar en el contexto del COVID-19
Authors: Cornejo Sánchez Jesús Fernando , Castillo Paola Miranda , Hurtado Nancy Arbulu , Payano Blanco Jakelyne Ingrido 
Published: February 2022

La familia como institución dentro de la sociedad ha demostrado ser el soporte psicológico, físico, social de sus integrantes ante la crisis generada por la pandemia de la COVID-19. La revisión sistemática tuvo por objetivo analizar el proceso de adaptación familiar ante el confinamiento y aislamiento social en el contexto de la COVID-19. La investigación se realizó teniendo en cuenta la metodología de la declaración PRISMA. La información científica se obtuvo de Scopus, EBSCO, Google Académico y Proquets. El proceso de identificación, cribado, elegibilidad e inclusión se desarrolló en un periodo de dos meses. De las 1693 revisiones que arrojó la búsqueda especializada, solo se seleccionaron 23. Se concluye que las familias han tenido que adaptarse a la pandemia de la COVID-19 convirtiendo su hogar en multiactividades, sin embargo, el proceso de adaptación no ha sido el mismo para todas las familias.
Estrategias de textualización para mejorar la producción de textos expositivos en estudiantes de secundaria
Authors: Supo Condori Felipe , Jaramillo Ostos Dennis Fernando , Mamani Paredes Javier , Cespedes Paduro Bernado , Quiñones Li Aura Elisa 
Published: February 2022

El estudio tuvo como objetivo demostrar la mejora significativa en la producción de textos explicativos tras la aplicación de la estrategia de textualización en alumnos de una escuela secundaria ubicada en Lima. Tiene un enfoque cuantitativo de tipo aplicada con diseño cuasi experimental. La población estuvo conformada por 309 estudiantes, la muestra fue no probabilística y estuvo formada por 52 estudiantes. La técnica utilizada fue la observación y los instrumentos utilizados fueron una rúbrica de medición de la producción de textos expositivos y el instrumento de prueba de redacción. La validez fue dada por juicio de expertos y la confiabilidad se comprobó mediante el estadístico alfa de CronBach aplicado a una muestra piloto de 30 estudiantes. Según los resultados obtenidos se concluye que la producción de textos expositivos mejora significativamente al aplicar la estrategia de textualización en estudiantes de secundaria de una escuela pública de Lima, ya que los resultados del estadístico U-Mann-Whitney: 5,546 y p= 0,000.