bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nalaten in de digitale wereld
Authors: Diks J.Th.M. , Lavrijssen N. 
Published: April 2022

Nalaten in de digitale wereld
De samenleving digitaliseert, en deze ontwikkeling is ook van invloed op het erfrecht. Deze bijdrage zoomt in op de mogelijkheden en uitdagingen van digitale technologie voor het erfrecht vanuit een praktisch perspectief. Daarbij wordt onder andere ingegaan op het teletestament, de begrippen ‘digitaal goed’ en ‘digitale erfenis’, bitcoins en andere digitale betaalmiddelen, en accounts en data van de erflater.
Uiterste wilsbeschikkingen ter voldoening aan een natuurlijke verbintenis
Authors: Brinkman R.E. 
Published: April 2022

Uiterste wilsbeschikkingen ter voldoening aan een natuurlijke verbintenis
In deze bijdrage wordt getracht antwoord te geven op de vraag of makingen beschouwd kunnen worden als de nakoming van een natuurlijke verbintenis. Zo dat het geval is, heeft dat tot gevolg dat de inkorting respectievelijk vermindering van die makingen (bij de legitieme portie en andere wettelijke rechten respectievelijk bij een ontoereikende nalatenschap) pas na andere makingen in aanmerking komt. De conclusie luidt dat een dergelijke making als zodanig moeilijk is in te passen in het systeem van de wet, maar bij wijze van inperking van de testeervrijheid, als fictie of als toepassing van de redelijkheid en billijkheid, niettemin als mogelijkheid moet worden erkend.
Improving the technique of precision strikes in teaching students of professional training of educational organizations of the Ministry of Internal Affairs of Russia fighting techniques of wrestling.
Authors: Aseev Sergey Viktorovich , Ermolenko Dmitrii Aleksandrovich 
Published: April 2022

The subject of the study is to increase the effectiveness of the technique of precision strikes of students of educational organizations of the Ministry of Internal Affairs of Russia with the use of weights in special sets of exercises.The object of the study is the organization of the educational process of students of the Faculty of vocational training of educational organizations of the Ministry of Internal Affairs of Russia in the discipline "Physical training". The author examines in detail such aspects as the use of special weights and the improvement of coordination abilities. Special attention is paid to the analysis of the traditional system of training students of the Ministry of Internal Affairs of Russia; the use of weights in the form of weights not of the maximum weight, while improving coordination abilities in teaching students the accuracy of punches and kicks. В The main conclusions of the study are that the process of teaching percussion techniques in physical training classes with students of vocational training on the topic "Strikes and protection from blows" contributes to an increase in the accuracy of punches and kicks than classes on the traditional training system. The author's contribution to the research of the topic is: the definition and justification of the purpose and objectives of the study, the choice of the subject and object of research, the justification of the author's methodology.The novelty of the research lies in the development of special complexes consisting of shock technique exercises, which improve the high-speed qualities of shock technique, the accuracy of hitting the target and coordination abilities.
Countering manifestations of extremism in the implementation of administrative supervision and judicial control in the field of communications, information technology and mass communications
Authors: Vodianaia Mariia , Lyashuk Anna Valer'evna 
Published: April 2022

The article is aimed at further improving the legal support of law enforcement activities of internal affairs bodies in the field of countering extremism. The subject of the study is the norms of administrative legislation regulating public relations in the field of administrative supervision of the police and judicial control in the field of countering administrative offenses of extremist orientation in the telecommunications network "Internet", as well as materials of judicial practice and law enforcement activities of police officers. The work uses a set of general scientific methods of cognition, such as dialectical, hermeneutical and systematic approach. Private scientific methods were used, such as formal legal and statistical research methods. В The authors consider in detail the problem of optimizing counteraction to extremism in the process of administrative supervision of the police, as well as as a result of judicial control over the resolution of cases of administrative offenses of extremist orientation identified during the implementation of state supervision in the field of communications, information technology and mass communications. The characteristic mistakes of law enforcement are revealed, consisting in the excessive application of administrative coercion measures to persons brought to administrative responsibility for extremism. The authors come to the conclusion that it is necessary to change the approach in the perception of the concept of "extremism" in the telecommunications sphere as a phenomenon of "extreme" radical behavior. The ways of improving legislation and law enforcement activities in this area are proposed.
The scribe book of the Tver half of the Bezhetskaya Pyatina in 1545: publication of the source in the web gis environment
Authors: Stepanova Iuliia , Frolov Alexey , Gavrilov Pavel Vladimirovich , Savinova Anna Igorevna 
Published: April 2022

The article discusses the experience of online publication of the scribe book of the Tver half of the Bezhetskaya Pyatina of the Novgorod land in 1545 on the NextGIS Web platform. The scribe's Book of 1545 is the most complete source describing the territory of the Tver half of the Bezhetskaya Pyatina of the XVI century. The book reflects the composition of landowners not only of the XVI century, but also of the period of independence of Veliky Novgorod. The paper describes methods of working with the geographical information of the book, creating geodata based on it and ways of presenting them in a web format. Attention is paid to various technical solutions, their strengths and weaknesses are considered. В The novelty of the research lies in a new look at the auxiliary element of the NextGIS Web web map, which is the Description displayed on the functional panel of its interface. The proposed approach turns the interactive geographical pointer accompanying the map into a platform for full-text publication of the source, in which the map performs the function of a container, always ready to display exactly the spatial context in which the geographical object selected by the user exists from the text of the historical source of the source. The main conclusion of the work is the conclusion that the proposed method allows you to combine the transmission of the main elements of the paper publication of the source with the advantages of a modern digital format, expanded due to the cartographic component.
Assessment of Liver Function and Its Correlation with Inflammatory Markers and Severity of Disease during COVID-19 Second Wave in a Tertiary Care Centre
Authors: Dhotra Arun , Anand A. , Shaikh Kani , Akilandeshwari A. R. , Arun N. 
Published: April 2022

Aims: To assess the Liver function in COVID-19 infection and study its correlation with inflammatory markers and severity of disease.
Study Design: A Retrospective Observational study.
Place and Duration of Study: Government Kilpauk Medical College, Chennai, India. Two month study period was taken during the second COVID wave (1st May 2021 to 30th June 2021).
Methodology: The study covered all COVID-19 positive individuals who were over the age of 19. Patients with any chronic liver disease, Hepatitis B or Hepatitis C were excluded. Data was collected from case files. Record was made of the liver function tests and inflammatory markers – C-Reactive Protein and Interleukin-6 (CRP, IL-6). Severe disease was defined as patients with respiratory rate > 30/min, SpO2 <90% on room air or requiring Intensive Care Unit (ICU) admission or mechanical ventilation. Collected data was analysed using appropriate statistical tests.
Results: 132 patients were included in the study. Out of these 59 patients (44.70%) had elevated Liver function tests (LFTs). Maximum patients (42.37%) had hepatocellular pattern. 59.32% patients were males. Mean age of patients with elevated LFTs was 51.03±13.03 years. ICU admission was required in 40.68% of patients with deranged LFTs compared to 23.28% in patients with normal LFTs, which was statistically significant (P <0.03). A positive correlation was found between deranged LFTs and inflammatory markers (CRP, IL-6). (P <0.001).
Conclusion: A significant number of COVID-19 positive individuals have abnormal liver function. Inflammatory indicators and elevated LFTs have a positive relationship. Patients with abnormal liver function tests were more likely to have severe illness.
Laboratory Performance Evaluation of Wantai HIV 1/2 Rapid Test Kit
Authors: Johnson Onoja Ali , Rubainu Manason , E. Ekanen Ekanem , Olaniyi Felix Sanni , Araoye Segilola 
Published: April 2022

Background: Detection of specific antibodies in the blood/body fluids is the primary testing method for HIV infection. A rapid test is one of the assays used in detecting HIV-specific antibodies. This study was conducted to evaluate the laboratory performance of the Wantai HIV 1/2 Rapid Test Kit.
Study Design: Cross-sectional laboratory-based performance characteristics study.
Place of Study: The study was conducted across all the six geopolitical zones in Nigeria (North Central, North East, North West, South West, South East, and South-South).
Methodology: This study was a cross-sectional laboratory-based performance evaluation with specimens obtained from Nigeria’s six geopolitical zones, characterised in the reference laboratory, and used to evaluate the Wantai test-kit. Ten millilitres of whole blood were collected from all the study sites in EDTA vacutainer tubes through venous puncture from participants, coded, centrifuged, and plasma harvested into cryovials in three aliquots of 2mls each. All specimens were retested using a combination of determine and Unigold rapid test kits. Samples that tested positive or negative concordantly with these kits were used to evaluate the Wantai HIV test kit. The data were entered in Excel and analysed with IBM-SPSS-version 25.
Result: Of the 1353 samples, 697 were HIV positive, and 656 were negative. Wantai RTK accurately detected 694(99.6%) positive and 649(98.9%) negative samples. Its sensitivity was 99.57% [95% CI:98.75%-99.91%], and the specificity was 98.93%[95%CI:97.81%-99.57%], with 99.26%[95%CI:98.64%-99.64%] accuracy. Collecting the correct plasma volume was at a 90.0% rate, reading the test result within the time limit, line visibility, interpreting the result, learning the procedure, design of the kit and waste generated were all at the rate of 100.0%.
Conclusion: With a sensitivity of 99.6% and a specificity of 98.9%, the Wantai HIV rapid test is suitable for inclusion as a first-line (screening) test in Nigeria’s HIV testing algorithm.
Ultrasonographic Assessment of Third Trimester Fetal Kidney Length as a Measure of Gestational age in Growth Restricted Fetuses
Authors: Mohamed Eldafrawy Nadra Elsaid , Ali Mohamed Hussein Naglaa , Mohamed Tawfek Elbadry Amr , Mohamed AgIlan Nagwa Ibrahim 
Published: April 2022

Background: Obstetric ultrasound is the first imaging modality used to assess the foetus and track its development. When the last menstrual period (LMP) is unknown, foetal ultrasonography can help with dates. According to studies, over 30% of pregnant women forget their LMP date. When the gestational age (GA) is uncertain, the pregnancy's outcome may be undesirable. To assess the ultrasonographic fetal kidney length as a measure of gestational age in third trimester.
Methods: All participant women were in the third trimester whose gestational age was calculated by reliable LMP which was confirmed by recorded ultrasonic measurement of BPD, AC& FL).
Participant women were divided into 2 equal groups:
Group 1: normal pregnancy & average.
Group 2: patients with growth restriction fetuses.
Results: The mean length and width of the left kidney were similar in both groups, as the mean length of the left kidney in the IUGR group was (38.40 ± 4.000) while it was in the control group (38.17 ± 3.637). The average width of the left kidney in the intrauterine growth restriction group was (23.09 ± 2.339) while it was in the control group (23.16 ± 2.341), there were significant positive correlations between the different study variables. A positive association was found between gestational age, fetal weight, bipolar diameter, femur length and abdominal circumference with the length of the right kidney, and they also found a positive association with the length of the left kidney.
Conclusions: In absence of renal anomalies/ abnormalities, kidney measurements; length, weight, volume can be used to determine gestational age accurately.
No difference between measuring Rt or Lt kidney on determining GA. Also, no difference between measurements in female or male fetuses.
Kidney measurement is not affected in cases of IUGR and can be used as a reliable indicator for actual gestational age of the fetus in these cases.
Antibiotics Sensitivity of Escherichia coli to Different Concentrations of Combined Herbal Drugs
Authors: Tombari Pius Monsi , Okechukwu Chiejina Somkene , Clement Ugochukwu Nyenke , Smart Enoch Amala 
Published: April 2022

Background: The use of combinational approach in chemotherapeutic management has proven more effective against infectious disease and lower resistance development but the untoward effect of this is yet to be explored for alternative medicine.
Aims: This study aimed to study the effect of a combinational approach of herbal drugs on Escherichia coli response.
Methods: E. coli was treated in different concentrations of combined herbal drugs (Beta herbal drugs and Deep root herbal mixture – BD) and (Beta herbal drug and Goko cleanser – BG). The different concentrations of the mixtures employed were: 33.3%, 11.1%, 3.7%, 1.2% and 0.4%. The bacteria concentration of 103 CFU/ml was treated in the different concentrations of the herbal drugs. The growth response of the cultures were analyzed at 24 and 48 hrs. The antibiotic sensitivity of the bacteria exposed to the herbal drugs were measured against perfloxacin (PEF), ciprofloxacin (CIP), streptomycin (S), and septrin (SEP).
Results: The growth response curve showed growth of E. coli peaked in the lower concentrations but levelled down in the higher concentrations. 24 hr growth conditions showed much higher growth level than 48 hr. Higher concentrations of BG drug combination showed higher zones of clearance and only one concentration showed resistance: 0.4% (CIP). There was no unique pattern seen in the sensitivity of E. coli treated with BD however, there was five (5) cases of complete resistance: 0.4% (PEF), 1.2% (PEF) and 11.1% (CIP and SEP).
Conclusion: In vitro, the combined herbal drugs do not completely eliminate E. coli. However, some concentrations of the combinations demonstrated complete resistance to the antibiotics which shows that these locally made antimicrobial could confer antibiotic resistance to E. coli.
Determinants of Post-harvest Losses of Pineapple: A Farm-level Study in Moulvibazar District, Bangladesh
Authors: Begum Maimuna , Marium Bibi , Bhattachirjee Pia Modhumita , Begum Ayesha 
Published: April 2022

Aims: Post-harvest losses are acknowledged as one of the major reasons for fresh grain production, especially fruit production in most developing countries. Thus, the present study is highlighted the perishable nature of the food and inefficient post-harvest management are one of the key reasons for fruit (pineapple) losses in the Moulvibazar district.
Study Design: This article is about determinants of post-harvest losses study and is placed on empirical analysis. It was carried out to find out what factors influence pineapple post-harvest losses at the farm level.
Place and Duration of Study: Sreemangal, Barlekha, Kulaura, Juri, and Rajnagar Upazilas were purposively chosen for this study because they represent the five most important pineapple producing locations in the Moulvibazar district. The study period was the harvesting season of pineapple from April to June 2019.
Methodology: Structured questionnaires were used to collect relevant information during face-to-face interviews with 320 pineapple farmers who were chosen using simple random sampling. Then the data were examined using descriptive and inferential statistics such as chi-square and factor analysis.
Results: The descriptive analysis shows that, based on the ranking of percentage, all pineapple farmers (100%) were engaged in the marketing of pineapple in order to reduce losses by exploring both direct and indirect means to sell their produce. This means that in order to avoid losses, finding a market for pineapples is important. There was a substantial link between the level of education (P=0.049), farm size (P=0.000), farm experience (P=0.021), yield (P=0.000), and post-harvest losses, as per chi-square analysis. Furthermore, according to the findings of the factor analysis, harvesting, grading, sorting, storage, packaging, transportation, and marketing are all aspects that affect post-harvest losses of pineapple at the farm level in the study area. Implementing proper storage and packaging facilities can reduce pineapple farmers' losses and make it easier for them to market their products year-round. Moreover, sorting and grading pineapple increases its price, enabling more effective marketing.
Conclusion: It has been shown that the transportation system has a substantial impact on pineapple distribution in the study area. Thus, it is logical to say that the transportation infrastructure should be upgraded in order to reduce pineapple post-harvest losses.
Highly Luminescent and Ultra‐Stable Perovskite Films with Excellent Self‐Healing Ability for Flexible Lighting and Wide Color Gamut Displays
Authors: Luo Chengzhao , Xia Wenlin , Ren Zhenwei , Shen Dongyang , Li Qinyi , Zheng Zhishuai , Li Jie , Ma Wenchen , Chen Yu 
Published: April 2022

AbstractMetal halide perovskite quantum dots (QDs) and polymer composite films have witnessed extensive investigation in flexible optoelectronic devices, while the unsatisfactory environmental and mechanical properties of the composite films set substantial limitations for practical applications. Herein, highly luminescent perovskite QDs‐polymer composite films (QPFs) are fabricated with remarkable environmental and mechanical stabilities by incorporation of perovskite QDs into fluoroelastomer polymeric matrix. The stretchable QPFs show excellent self‐healing ability with micron‐ and centimeter‐scale cracks healed in dozens of minutes and hours, respectively, due to the strong dipole–dipole interaction between the CF bonds of fluoroelastomer. After careful optimization of QDs ratios, a flat and smooth film morphology is achieved with a uniform distribution of QDs, which promotes good optical properties with a long PL lifetime of 1213.75 ns and high photoluminescence quantum yields up to 96.1%, and super environmental and mechanical stability These merits of QPFs enable their practical applications in flexible white light‐emitting devices and wide color gamut displays with 124% of standard National Television Standards Committee and 96% of Recommendation 2020, respectively, exhibiting vivid pictures with high saturations for the object colors, indicating great potential toward practical applications.
Cascade Downregulation of the HER Family by a Dual‐Targeted Recombinant Protein–Drug Conjugate to Inhibit Tumor Growth and Metastasis
Authors: Yuan Yang , Zhou Sensen , Li Cheng , Zhang Xiaoke , Mao Hui , Chen Weizhi , Jiang Xiqun 
Published: April 2022

AbstractHuman epidermal growth factor receptor type 2 (HER2)‐targeted therapy can significantly improve the outcome of patients with HER2 positive cancer. However, relapse after this treatment remains a great challenge in the clinic due to tumor resistance, in which the HER network induces constitutive signal transduction. In addition, integrin receptors in the tumor extracellular matrix can mitigate the therapeutic effect of inhibitors to the growth factors receptors and tyrosine kinases. Here, the development of a recombinant protein (RP‐HI) and its drug conjugates (RPDC‐HI) to target both HER2 and integrin is reported. When simultaneously blocking HER2 and integrin by RP‐HI, functions of the HER family and their interactions with the integrin are disrupted by downregulated expressions of HER family members, leading to inhibition of several downstream signal pathways. In combination with targeted delivery of the anticancer agent, doxorubicin (DOX), RPDC‐HI significantly improves the tumor inhibition efficacy to 97.5% in treating HER2‐positive breast cancer, comparing to 34.3% for free DOX. RPDC‐HI shows even better antitumor efficiency than a monoclonal antibody, trastuzumab, when treating larger tumors. The developed dual‐targeted RPDC platform offers a new and promising strategy for treating HER2‐positive patients with synergistic therapeutic effects against tumor resistance to the conventional HER2‐targeted treatment.
Diverse clinical manifestations and intrafamilial variability due to an inherited recurrent MYRF variant
Authors: Gupta Neerja , Endrakanti Mounika , Gupta Noopur , Dadhwal Vatsla , Naini Kamal , Manchanda Smita , Khan Ragib , Jana Manisha 
Published: April 2022

AbstractMYRF monoallelic variants have been described in syndromic forms characterized by cardiac‐urogenital syndrome and isolated nanophthalmos with/without minor systemic manifestations. We describe a large family with a paternally inherited pathogenic variant in MYRF that manifested as congenital diaphragmatic hernia (CDH), cardiac and urogenital abnormalities, and/or nanophthalmos with significant intrafamilial variability.
Identifying best practices for disclosure of amyloid imaging results: A randomized controlled trial
Authors: Fruijtier Agnetha D. , van der Schaar Jetske , van Maurik Ingrid S. , Zwan Marissa D. , Scheltens Philip , Bouwman Femke , Pijnenburg Yolande A.L. , van Berckel Bart N.M. , Ebenau Jarith , van der Flier Wiesje M. , Smets Ellen M.A. , Visser Leonie N.C. 
Published: April 2022

AbstractIntroductionEmpirical studies on effective communication for amyloid disclosure in mild cognitive impairment (MCI) are lacking. We aimed to study the impact of six communication strategies.MethodWe performed a randomized controlled trial with seven randomly assigned, video‐vignette conditions: six emphasizing a communication strategy and one basic condition. All showed a scripted consultation of a neurologist disclosing positive amyloid positron emission tomography (PET) scan results to an MCI patient. Healthy individuals (N = 1017; mean age ± SD 64 ± 8, 808 (79%) female) were instructed to imagine themselves in the video, answered questionnaires assessing information recall, emotional state, and behavioral intentions, and evaluate the physician/information.Results“Risk best practice” resulted in highest free recall compared to other strategies (P < .05), except “emotional support”. Recall in “emotional support” was better compared to “basic‐‘ and elaborate information”(P < .05). “Risk best practice” resulted in the highest uncertainty (P < .001). “Teach‐back” and “emotional support” contributed to the highest evaluations (P ‐values < .01).ConclusionRisk communication best practices, attending to emotions, and teach‐back techniques enhance information recall of amyloid‐PET results, and could contribute to positive care evaluations.