bluuebunny/crossref_metadata_2025_split huggingface dataset:
Luminescent gold nanoclusters as a signal reporter for cytochrome c assay with a double signal amplification strategy
Authors: Dou Min‐Na , Wu Yifan , Du Jianxiu 
Published: August 2022

AbstractQuantitative determination of serum cytochrome c (Cyt c) is of importance in the regular medical assessment of cancer diseases. This work reported a new fluorescence method for the determination of Cyt c with glutathione‐protected gold nanoclusters (GSH‐AuNCs) as a signal reporter. Cyt c was observed to quench the fluorescence of GSH‐AuNCs due to its electron‐rich structure. This inhibitory effect was further strengthened by its peroxidase mimetic catalytic activity on hydrogen peroxide (H2O2)‐mediated oxidation of GSH‐AuNCs. The inhibitory efficiency was linearly related to Cyt c concentrations ranging from 10.0 to 700.0 nM with a limit of detection of 2.7 nM (3sb/S). The relative standard deviation was 3.6% for Cyt c at a 40.0 nM concentration level (n = 11). The practical application of the method was evaluated by the determination of Cyt c in spiked human serum samples. The recoveries were within the range from 92.6 to 104.8%, suggesting its potential application in biomedical and clinical diagnosis.
Effect of chemical treatment on the structural, thermal, and mechanical properties of sugarcane bagasse as filler for starch‐based bioplastic
Authors: Hamin Siti Hajar , Sayid Abdullah Sharifah Hanis Yasmin , Lananan Fathurrahman , Abdul Hamid Siti Hajar , Kasan Nor Azman , Mohamed Nurul Najidah , Endut Azizah 
Published: August 2022

AbstractBACKGROUNDThe demand for green products is pushing industries to search for more eco‐friendly materials, especially for food packaging applications. Starch biopolymer has been recognized as biodegradable material that can be produced from various plants. However, the strength of starch‐based bioplastic retards their widespread application. Simultaneously, the high amount of agricultural waste produced by the food industry has been a growing environmental issue. Incorporating agro‐waste fibers as a biofiller in starch‐based bioplastic can improve the properties of the bioplastic, allowing its use in various applications. Thus, this study aims to evaluate the effect of chemical treatment on the structural, thermal, and mechanical properties of sugarcane bagasse as filler for starch‐based bioplastic.RESULTSResults showed that alkaline treatment improved surface roughness and freed it of surface impurities. Results revealed that the thermal stability and mechanical properties improved significantly with the incorporation of sugarcane bagasse (SB) loading into potato starch (PS). The highest tensile strength (5.30 MPa) and Young's modulus (28.72 MPa) were exhibited by the sample with 6% SB loading and further increments of SB led to a decrease in the strength of the biopolymer.CONCLUSIONThe incorporation of alkali‐treated SB could increase and enhance the tensile strength and thermal stability of the bioplastic. This would contribute to reinforced materials that will allow for the application of PS as a new potential biodegradable material. Thus, it reduces the disposal period process and has great potential as an environmentally friendly, biodegradable, and renewable material. © 2022 Society of Chemical Industry (SCI).
Antioxidant and cytotoxic properties of some new dipeptide‐indole conjugates
Authors: Gönül Zeynep , Öztürk Dilara Altay , Küçükbay Fatümetüzzehra , Tekin Suat , Tekin Zehra , Küçükbay Hasan 
Published: August 2022

AbstractIn this study, 10 new indole‐dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) and MCF‐7 (breast cancer cell line) cells. Among compounds, 5 and 10 showed better activity against A2780 cell lines than the standard drug docatexel at 0.1 and 1 μM concentrations, while only compound 5 showed better activity than docatexel, the MCF‐7 cell line at 0.1 and 1 μM concentrations. The antioxidant potencies of the compounds were low in both the DPPH and iron reducing power methods tested when compared to standard antioxidants used in this work.
A case of infectious mononucleosis complicated with spontaneous atraumatic splenic rapture caused by Epstein–Barr virus infection
Authors: Lu Qiliang , Fu Wen , Ouyang Guangxiong , Xu Qiuran , Huang Dongsheng 
Published: August 2022

AbstractSplenic rupture is the most serious complication of infectious mononucleosis (IM) caused by Epstein–Barr virus (EBV) infection, with a mortality rate of over 1 in 10. We reported a case of spontaneous atraumatic splenic rupture secondary to IM in a young man. The patient presented with abdominal pain caused by splenic rupture as the initial symptom. The diagnosis and treatment process went through a series of twists and turns, including the emergency department, general surgery department, and infection department. This case suggests that clinicians should consider the possibility of EBV infection in young patients with spleen rupture without obvious cause to avoid misdiagnosis and missed diagnosis.
Systematic assessment of GPM IMERG V06 precipitation products with dense rain gauge observations over Zhejiang Province, China
Authors: Bi Zaoying , Sun Shanlei , Shen Huayu , Liu Yi , Ren Yongjian , Li Jinjian , Lin Bin 
Published: August 2022

AbstractThis study systematically assessed the performance of the Integrated Multi‐satellitE Retrievals (IMERG) for Global Precipitation Measurement V06, including the near‐real‐time “Late Run” (IMERG‐L) and the post‐real‐time “Final Run” (IMERG‐F), over Zhejiang Province (ZJP), China. The evaluation was conducted at daily and hourly timescales for a full year and for each season, based on dense rain gauge observations and continuous and categorical validation statistics. For the full year and for each season, IMERG‐F outperformed IMERG‐L in representing the spatial pattern of multiyear mean precipitation. For regional mean of ZJP, IMERG‐F and IMERG‐L overestimated the daily/hourly precipitation for the full year by 6.51 and 4.98%, respectively. Among seasons, the regional mean relative biases for IMERG‐F were between 5.65 and 8.63%; however, for IMERG‐L, they exhibited notable variations with a maximum of 11.09% in fall and a minimum of 0 in spring. Bias composition suggested that the regional mean overestimations were largely due to false bias for the full year and for each season, except in winter, wherein it was due to hit bias. Spatially, the biases for the full year and for each season commonly arose from false and hit biases at daily timescale, and from false and miss biases at hourly timescale. Based on the remaining continuous metrics (i.e., root‐mean‐square‐error [RMSE], correlation coefficient [CC], and Kling–Gupta Efficiency [KGE]) and all categorical metrics, the IMERG daily/hourly performance was acceptable on regional and grid scales throughout the year and in all seasons. From a region‐average perspective, IMERG‐F outperformed IMERG‐L according to CC, RMSE, and KGE, but both products showed the same performance overall based on all categorical metrics; most grids also share these characteristics. This study provides a valuable reference for IMERG developers to improve product accuracy from the perspective of the final postprocessing step and for potential users in ZJP.
Using Daily Creativity Planning to Promote Creative Behavior
Authors: Liu Ting , Li Pin , Zhang Skylor Zhitian , Liu Wanlun 
Published: August 2022

ABSTRACTResearch has demonstrated that on the path from a creative idea to a creative outcome, high creativity motivation and self‐efficacy do not necessarily lead to creative behavior. The present study proposed and examined the notion that daily creativity planning could promote creative behavior and contribute to the cultivation of creativity. A total of 77 middle school students (39 students in the experimental group and 38 in the control group) participated in this study, for which a quasi‐experimental design was administered. The experimental group conducted a two‐week daily planning for creative activities, while the control group did not conduct any intervention. The results showed that students' creativity motivation and creative self‐efficacy were at relatively high levels overall and were positively and moderately correlated with creative behavior. Daily planning could effectively facilitate students' creative behavior. These findings point to a promising and simple creativity enhancement strategy for cultivating students to develop the habit of making creative plans in their daily lives.
Risk factors for venous thromboembolism (VTE) after adrenalectomy for adrenal cortical neoplasms
Authors: Moore Maureen D. , Agrusa Christopher , Ullmann Timothy M. , Beninato Toni , Zarnegar Rasa , Fahey Thomas J. , Finnerty Brendan M. 
Published: August 2022

AbstractBackgroundIncidence of venous thromboembolism (VTE) after adrenalectomy for adrenal cortical carcinoma (ACC) is unknown. Herein, we aim to identify the relative incidence and risk factors of VTE after adrenalectomy for ACC.MethodsThe American College of Surgeons National Surgical Quality Improvement Program database was queried to identify patients who underwent adrenalectomy for ACC, Cushing syndrome (CS), and benign adrenal cortical syndromes (BACS). Univariable and multivariable analyses were used to determine clinical characteristics, 30‐day postoperative VTE occurrences, and associated risk factors. Khorana oncologic risk score (KRS) for VTE was calculated and compared between groups.ResultsA total of 5896 patients were analyzed: 576 ACC, 371 CS, and 4949 BACS. Postoperative VTE occurred 0.9%, with the highest rate occurring in ACC (2.6% ACC vs. 1.6% CS vs. 0.7% BACS, p < 0.001). Forty percent of VTEs in the ACC cohort were diagnosed postdischarge. ACC patients with KRS ≥ 2 had a 9.6% incidence of VTE (p = 0.007). Multivariable analysis identified increased age (p = 0.03), presence of adrenal cancer (p = 0.01), and KRS ≥ 2 (p = 0.005) as risk factors for VTE after adrenalectomy.ConclusionsPostoperative VTE after adrenalectomy occurs most frequently for ACC. ACC patients with increased age and/or Khorana score ≥2 should be considered for extended VTE prophylaxis.
Dermatofibrosarcoma protuberans surgery: Experiences of four African surgical oncology units and literature review
Authors: Zongo Nayi , Guigemdé R. Adeline , Yaméogo Parateyandé B. , Somé Roland Ollo , Traore Bangaly , Dem Ahmadou 
Published: August 2022

AbstractBackground and ObjectivesDermatofibrosarcoma is a locally malignant tumor. This gives surgery a place of choice. The advent of imatinib has improved outcomes. Our aim is to describe the indications, techniques and results of surgery.MethodsA retrospective, multicenter, descriptive study conducted in four West African surgical oncology units. It covers dermatofibrosarcoma surgery performed between January 1, 1988 and December 31, 2020. We took into account the surgical procedure, the mode of skin coverage, adjuvant treatments and survival. Comparisons were possible using Student's t‐test and Pearson's χ2.ResultsWe recorded 81 cases of dermatofibrosarcoma. Surgery was effective in 90.1% of cases. Wide resection was the principle with a mean resection margin of 3.8 ± 1.9 cm. healing by primary intention, flaps and healing by secondary intention were the methods of skin coverage in 30.1%, 24.7% and 41.1% respectively. The type of skin coverage was related to the topography and size of the tumor (p < 0.0001). The healing time is associated with the type of skin cover. The recurrence rate was not related to the type of skin coverage (p = 0.8).ConclusionsWide and deep resection in the absence of Mohs micrographic surgery ensures healthy margins. Oncoplasty reduces the healing time without increasing the risk of recurrence.
n‐Heptane oxidation in a high‐pressure flow reactor
Authors: Thorsen Lauge Sven , Jensen Malene Stryhn Thestrup , Pullich Mille Stub , Christensen Jakob Munkholt , Hashemi Hamid , Glarborg Peter 
Published: August 2022

AbstractThe oxidation properties of n‐heptane have been investigated by conducting experiments in a laminar flow reactor at pressures of 21 and 100 bar, near‐stoichiometric () and fuel‐lean conditions (), and temperatures of 450–900 K. At 21 bar and stoichiometric conditions, a negative temperature coefficient (NTC) region was detected around 600 K. At increased pressure or oxygen concentration, the NTC behavior was much less pronounced. The observed concentration profiles for the major species were compared to predictions with selected literature mechanisms. While all models provided a satisfactory agreement for the n‐heptane profiles at 21 bar fuel lean conditions and at 100 bar, only the mechanisms from NUI and Polimi captured the NTC behavior at 21 bar and stoichiometric conditions. The model from Zhang et al. provided the best overall agreement and was selected for detailed comparison with species concentrations and used in analysis of reaction paths and reaction sensitivity under the present conditions.
Predicting Pathologic Lymph Node Positivity in cN0 Pharynx and Larynx Cancers
Authors: Anderson Eric M. , Luu Michael , Lu Diana J. , Chung Eric M. , Gay Christopher , Scher Kevin S. , Mita Alain C. , Mallen‐St. Clair Jon , Ho Allen S. , Zumsteg Zachary S. 
Published: August 2022

BackgroundElective neck dissection is a standard of care for pharynx and most larynx cancer patients undergoing surgery, based largely on historical series. It is unclear if this is necessary for all patients in the modern era.MethodsPatients with cN0 oropharynx, larynx, and hypopharynx cancers diagnosed from 2010–2015 undergoing primary surgery were identified in the National Cancer Data Base.ResultsInclusion criteria were met by 4117 cN0 patients. The presence of lymphovascular invasion (LVI) was the strongest independent predictor of pN+ (odds ratio [OR] = 4.19, 95% confidence interval [CI] 3.56–4.93, p < 0.001). Histologic grade strongly predicted pN+ (OR 2.58, 95% CI 1.88–3.59, p < 0.001). A nomogram predicted less than 10% of cN0 patients had pN+ risk <15%.ConclusionLVI and grade are the strongest predictors of pN+ among patients with cN0 pharynx and larynx cancer. Even in the modern era, pN+ rates warrant neck dissection for cN0 patients.Level of Evidence3 Laryngoscope, 133:1660–1666, 2023
Lack of a Zn/Co substitution ability in the polar diatom Chaetoceros neogracileRS19
Authors: Kellogg Riss M. , Moran Dawn M. , McIlvin Matthew R. , Subhas Adam V. , Allen Andrew E. , Saito Mak A. 
Published: August 2022

AbstractFunctional substitution of the essential trace metals zinc (Zn) and cobalt (Co) within metalloenzymes has been well documented in marine diatoms and is known to be prevalent among varying genera and species. In contrast to the majority of species studied to date, we find that the polar diatom Chaetoceros neogracile RS19, originally isolated from the Ross Sea, Antarctica, has a Zn requirement that cannot be met by Co and thus does not demonstrate a Zn/Co substitution ability as assessed by growth rate. We investigated this diatom's inability to use Co to alleviate Zn‐limited growth rates at the transporter, sensor/chaperone, and metalloenzyme level using metal quota and proteomic analyses of cultures grown over a range of Zn and Co availability. Analysis of total cellular metal quotas revealed that, although incapable of substitution, this diatom still actively assimilated dissolved Co. We furthermore observed distinct trends in the abundance levels of putative α and θ‐CAs, ZIP transporters, Zn fingers, and a Zn chaperone in response to increasing media Zn2+. Overall, Co appears to be transported into the cell, but not efficiently utilized by Zn metalloenzymes.
Identifying trait‐based tolerance to sediment dynamics during seedling establishment across eight mangrove species
Authors: van Hespen Rosanna , Hu Zhan , Peng Yisheng , Zhu Zhenchang , Ysebaert Tom , Bouma Tjeerd J. 
Published: August 2022

AbstractMechanical disturbance from waves and sediment dynamics is a key bottleneck to mangrove seedling establishment. Yet, how species vary in tolerance to sediment dynamics has not been quantified. We identified how tolerance to sediment dynamics differs for three mangrove propagule traits: propagule size, successional stage, and type of embryo development. We selected eight mangrove species growing in south China that vary from small seeds to large elongated propagules, pioneer to climax species, and non‐viviparous to viviparous. In a mesocosm set‐up, we applied bed level treatments to establishing seedlings: erosion, control, or accretion, by removing 2 cm, 0 cm, or adding 1 cm of sediment per week over 3 weeks. We measured seedling survival, shoot, and root lengths, and the critical erosion depth that leads toppling or dislodgement. We identified five relationships between seedling morphology and accretion and erosion thresholds: (1) tall (viviparous) propagules likely had highest accretion thresholds; (2) small pioneer propagules grew relatively fast to increase accretion thresholds; (3) there was a strong correlation between the erosion threshold and root length; and (4) climax species grew longest roots overall, (5) while pioneer species grew longer roots fast in response to sediment erosion. We identify distinct strategies for successful establishment in sediment dynamics that contribute to understanding mangrove zonation and underpin the importance of restoring diverse forests containing not just robust climax species, but also adaptable pioneers. Furthermore, this study reveals maximum shoot and root length as key determinants for seedling stability across species, providing a simple proxy for modeling establishment events.
Climate warming amplifies the frequency of fish mass mortality events across north temperate lakes
Authors: Tye Simon P. , Siepielski Adam M. , Bray Andrew , Rypel Andrew L. , Phelps Nicholas B. D. , Fey Samuel B. 
Published: August 2022

AbstractRecent increases of animal mass mortality events have coincided with substantial changes in global climate. Yet, tractable approaches that predict how climate change will accentuate occurrences of these ecological catastrophes remain nascent. We compiled one of the most comprehensive datasets of lentic fish mortality events, thermal tolerances of affected families, and 1.2 million air and water temperature profiles across 8891 north temperate lakes in North America. Temperature extremes within and across lakes were strongly associated with the three most frequent cause types (infectious agents, summerkills, winterkills). Thermal tolerances mediated the lethality of direct thermal stress, but mortalities of warm‐ and cold‐water fishes occurred at similar temperature deviations. Water and air temperature‐based models accurately predicted contemporary summerkills and suggested ~ 6‐ to 34‐fold increases, respectively, in their frequency by 2100. These models forecast and contextualize impending ecosystem changes in an increasingly volatile world.
Stakeholder‐engaged co‐design and implementation of web‐based tools to enhance the dissemination and implementation of AHRQ EPC reports
Authors: Shelton Erica , Mossburg Sarah , Thompson Lee , Savitz Lucy 
Published: August 2022

AbstractIntroductionA mission‐critical aspect of learning health systems (LHSs) is the provision of evidence‐based practice. One source of such evidence is provided by the Agency for Healthcare Research and Quality (AHRQ) through rigorous systematic reviews, termed evidence reports that synthesize available evidence on nominated topics of interest. However, the AHRQ Evidence‐based Practice Center (EPC) program recognizes that the production of high‐quality evidence reviews does not guarantee or promote their use and usability in practice.MethodsTo make these reports more relevant to LHSs and promote evidence dissemination, AHRQ awarded a contract to the American Institutes for Research (AIR) and its Kaiser Permanente ACTION (KPNW ACTION) partner to design and implement web‐based tools to meet the gap in dissemination and implementation of EPC reports in LHSs. We used a co‐production approach to accomplish this work across three phases of activity: planning, co‐design, and implementation between 2018 and 2021. We describe the methods and results and discuss implications for future efforts.ResultsWeb‐based information tools that provide clinically relevant summaries with clear visual representations from the AHRQ EPC systematic evidence reports may be used by LHSs to increase awareness and accessibility of EPC reports, formalize and enhance LHSs' evidence review infrastructure, develop system‐specific protocols and care pathways, improve practice at the point of care, and train and educate.ConclusionsThe co‐design of these tools and facilitated implementation generated an approach to making EPC reports more accessible and allows for more widespread application of systematic review results in supporting evidence‐based practices in LHSs.
Realizing Vat‐Photocycloaddition 3D Printing with Recyclable Synthetic Photorheological Silicone Fluids
Authors: Oka Minami , Takagi Hideaki , Orie Akihiro , Honda Satoshi 
Published: August 2022

AbstractSynthetic silicone rubbers are finding a broad spectrum of applications, yet there is a demand for developing greener silicone rubbers with processability, recyclability, and reversible tunability in their mechanical properties. Here, a recyclable photorheological silicone fluid (RPSF) is developed, which realizes completely reversible wavelength‐selective liquid–rubber conversion upon photoirradiation, relying on the reversible photocycloaddition of coumarin upon alternating irradiation of light with wavelengths of 365 (UV365) and 254 nm (UV254). Rheological studies demonstrate that the storage modulus of the developed RPSF increases by a factor of more than 100 000 upon UV365 irradiation to reach 20–50 kPa, while it decreases to ≈0.01 kPa upon UV254 irradiation. The reversibility of the photocycloaddition of coumarin enables the application of RPSF as a photodismantlable adhesive. Furthermore, unprecedented vat‐photocycloaddition 3D printing of silicone rubber is realized by taking advantage of the excellent photocurability, that is, the dramatic increase in viscoelasticity upon UV365 irradiation.
Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature
Authors: Moffitt Bridgette A. , Sarasua Sara M. , Ward Linda , Ivankovic Diana , Valentine Kathleen , Rogers Curtis , Phelan Katy , Boccuto Luigi 
Published: August 2022

AbstractBackgroundSleep is essential to maintaining a healthy life. Sleep disturbances among individuals with neurodevelopmental disorders are not well studied, affecting their early detection and treatment. Sleep disturbances in individuals with Phelan–McDermid Syndrome (PMS) are among the primary concerns reported by parents. However, little research has been aimed at addressing their concern.MethodsThe purpose of this investigation was to identify and quantify specific sleep disturbances in people with PMS by analyzing data collected by the PMS Foundation International Registry.ResultsThe registry shows that 284 out of 384 (73.4%) individuals with confirmed chromosome 22q13 deletions or SHANK3 pathogenic variants have a sleep disturbance. The prevalence of sleep disturbances increases with age with 56% reporting a sleep disturbance in the 0–3 year age group and 90% reporting these disturbances in those over age 18 years old. The primary sleep disturbances were circadian rhythm sleep disorders that included difficulty falling asleep, frequent nighttime awakenings, difficulty returning to sleep after a nighttime awakening event, and hypersomnia and parasomnias including enuresis, night terrors, sleepwalking, and sleep apnea. Sleep disturbances were similarly frequent among individuals with SHANK3 pathogenic variants (84.8%) and those with deletions (71.9%), supporting the role of haploinsufficiency of SHANK3 in sleep.ConclusionSleep disturbances are a common feature of PMS and should be considered in clinical evaluation and management because of the effect they have on the quality of life of the patients and their families.