bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of urbanization on the morphology of the Barak River floodplain in Cachar District, Assam
Authors: Nath Apurba , Ghosh Susmita 
Published: November 2022

AbstractIn the present study, the meandering behavior of the Barak River (Cachar), Assam was traced. Flow path length, meander neck length, sinuosity index, and river migration were determined segment-by-segment to demonstrate morphological changes. Decadal land-use land cover (LULC) maps were also prepared at the section scale using Landsat data (1990–2020) validated with the Kappa coefficient to characterize changes along alluvial floodplains. Urban growth and agricultural activities affect river morphology, especially where intensive agriculture was recorded, according to LULC studies. Due to urbanization, forestation constantly decreased, causing river variability. According to the results of the present study, river migration is very slow between Sec 1 and Sec 3. In terms of river stability, the parts are more stable, particularly Sec 1, which features less urbanization and agricultural activity than the other sections. The most vulnerable segments within the study area were considered to be Sec 2 and 4. There is a rather large amount of migration within sections, especially segments CC and GG. The river segments became more vulnerable as a new oxbow lake was formed and LULC changed over a decade. This stretch of Barak is characterized by a broad alluvial floodplain and is shifting since this study applies to various meandering types.
Retrospecting the researches and efforts on Lancang-Mekong water issues: a bibliometric perspective
Authors: Wang Wenjia , Wang Zhongjing 
Published: November 2022

Abstract
We adopted a spectral clustering algorithm to divide the document co-citation network of 1,776 papers in the field of Lancang-Mekong water, and 14 clusters were identified. For each cluster, the top-cited references construct the knowledge base, and the most-coverage cities are taken as the research frontier. Three indicators, namely betweenness centrality, citation burstness strength, and Sigma, were used to identify the research outputs with pioneering and transformative value. The changes in the research topics and hotspots are closely related to the planning, construction, and operation progress of hydropower engineering, that affected by the gaming results of all parties. The 2009–2010 is an important time boundary, with the original research hotspots including the impact of upstream reservoirs on the hydrological regime and sediment (Clu#3) and arsenic contamination of groundwater in the Lower Mekong (Clu#4) that obtained periodical achievements and reached consensus to some extent around 2008, and the new research boom turns to the Tonle Sap Lake and flood pulse (Clu#2) in short-term characterized literatures with the highest burstness strength mainly concentrated around 2012.
The Colloquy between Microbiota and the Immune System in Colon Cancer:
Repercussions on the Cancer Therapy
Authors: Saini Reena V. , Pal Soumya , Saini Adesh K. , Kaushal Ankur , Gupta Shagun , Gaur Naseem A. , Chhillar Anil K. , Sharma Anil K. , Gupta Vijai K. 
Published: November 2022

Abstract:
Colorectal cancer is the second leading cause of cancer deaths worldwide and has engrossed researchers'
attention toward its detection and prevention at early stages. Primarily associated with genetic and environmental
risk factors, the disease has also shown its emergence due to dysbiosis in microbiota. The microbiota
not only plays a role in modulating the metabolisms of metastatic tissue but also has a keen role in cancer therapy.
The immune cells are responsible for secreting various chemokines and cytokines, and activating pattern
recognition receptors by different microbes can lead to the trail by which these cells regulate cancer. Furthermore,
mixed immune reactions involving NK cells, tumor-associated macrophages, and lymphocytes have
shown their connection with the microbial counterpart of the disease. The microbes like Bacteroides fragilis,
Fusobacterium nucleatum, and Enterococcus faecalis and their metabolites have engendered inflammatory reactions
in the tumor microenvironment. Hence the interplay between immune cells and various microbes is utilized
to study the changing metastasis stage. Targeting either immune cells or microbiota could not serve as a
key to tackling this deadly disorder. However, harnessing their complementation towards the disease can be a
powerful weapon for developing therapy and diagnostic/prognostic markers. In this review, we have discussed
various immune reactions and microbiome interplay in CRC, intending to evaluate the effectiveness of chemotherapy
and immunotherapy and their parallel relationship.
Coalescence of Au Nanoparticles in Silica Aerogel under Electron Beam
Irradiation
Authors: Sammi Heena , Mohanta Manish , Sharma Bhagwati , Sardana Neha 
Published: November 2022

Background:
The coalescence of Au nanoparticles embedded in the silica gel matrix
was observed by E-beam irradiation in a transmission electron microscope.

Methods:
It was examined that interparticle spacing between nanoparticles was reduced after
incorporation into the matrix and particles came close to each other. TEM studies have shown
that during E-beam irradiation ~13 nm Au nanoparticles contacted with each other along with
the shrinkage of the silica aerogel or as well as the removal of surfactant layer, and transformed
into different shapes of particles such as dumbbell and chain-like particles as per the interparticle
gap.

Results:
This nanoparticle-aerogel matrix has the potential for applications in sensing, nonlinear
optics, and catalysis.

Conclusion:
This work enhances the understanding of the role of silica aerogel and E-beam
irradiation in directing the coalescence of nanoparticles.
Health Benefits, Therapeutic Applications, and Recent Advances of
Cirsilineol in the Medicine: Potential Bioactive Natural Flavonoids of Genus
Artemisia
Authors: Patel Dinesh Kumar 
Published: November 2022

Abstract:
Herbal medicine and its derived products have been used in the medicine and
nutraceutical sectors for the treatment of human disorders and associated secondary
complications. Plant-derived products play an important role in our daily life due to their
medicinal properties and pharmacological activities. The attention of scientists to natural products
has increased due to their significant biological activities. Flavonoids represent one of the most
important phytocompounds present in the higher plants, common fruits, vegetables, herbs, wine,
juices, and dried fruits. Flavonoids exert potent antioxidant activity by blocking and scavenging
free radicals. Cirsilineol, also called 4',5-dihydroxy-3',6,7-trimethoxyflavone, is an active
phytochemical of Artemisia vestita, Artemisia monosperma, Artemisia asiatica, and Agrostis
gigantea. Medicinal importance and pharmacological activities of cirsilineol have been
investigated in the present work with their analytical aspects in order to know the biological
importance of cirsilineol in medicine. Literature data on cirsilineol were collected and analyzed
in the present work to study its therapeutic potential against various human disorders and
associated secondary complications. Scientific data were collected from Google, Google Scholar,
PubMed, Science Direct, and Scopus and analyzed in the present work using the term herbal
medicine, flavonoid and cirsilineol. Medicinal plants containing a significant amount of
cirsilineol have biological applications in medicine due to their pharmacological activities. This
present work signifies the biological importance of cirsilineol in medicine as it has antiproliferative,
gastroprotective, anti-Helicobacter pylori, anti-diabetic and anti-oxidant activities.
Further therapeutic effectiveness of cirsilineol against different types of cancers, including breast
carcinoma and lung carcinoma, has been discussed in the present work. The biological importance
of cirsilineol against allergic rhinitis, inflammation, coronavirus, immune system, renal cellular
membrane and protein glycation has also been discussed in the present work. However, the
importance of analytical methods for the isolation and identification of cirsilineol in medicine has
also been analyzed. This work aimed to summarize the health-beneficial aspects of cirsilineol in
medicine which will be beneficial to explore the further therapeutic effectiveness of cirsilineol
for the treatment of various forms of human disorders.
Hospital-acquired Pressure Ulcers in Trauma Patients: A Retrospective Study of 410 Patients at a Referral Trauma Center in the North of Iran
Authors: Mobayen Mohammadreza , Karkhah Samad , Bagheri Parisa , Feizkhah Alireza , Moghadam Mahtab Taati , Mohmmadnia Hamideh , Sadeghi Mahsa 
Published: November 2022

Background:
Pressure ulcers (PUs) are among the most common chronic ulcers and complications of hospitalization.

Objective:
The present study aims to evaluate the prevalence of hospital-acquired PUs and their grades in trauma patients, comparing demographic characteristics, clinical features, and outcomes among patients without and with PUs referred to a trauma center in the North of Iran.

Methods:
In a retrospective study, 410 patients with trauma referred to a trauma center in the North of Iran were enrolled. Data were collected using a simple random sampling from March 2019 to September 2019.

Results:
The prevalence of PU in patients with trauma was 27.6%. Grade III (35.5%) and grade I (3.5%) wounds had the highest and lowest frequency of PU, respectively (P<0.001). The mean age of patients with PU was higher than patients without PU (61.73 vs. 47.71 years, P<0.001). The mean hemoglobin level of patients with PU was lower than patients without PU (9.93 vs. 12.25, P<0.001). PUs were more common in smokers compared to non-smokers (P<0.001), with a history of PU (P<0.001), a history of diabetes mellitus (P<0.001), and a history of hypertension (P<0.001). The mean length of stay in the hospital for patients with PU was higher than for patients without PU (13.02 vs. 5.54 days, P<0.001). 74.3% of people with PUs were completely immobile (P<0.001), and 60% of them had mild brain damage (GCS of 13 to 15). Also, the number of people with severe and moderate brain injury among PUs patients was 15% and 24.7%, respectively (P<0.001). Mobility, brain damage, Hemoglobin rate and smoking status were risk factors for pressure ulcers.

Conclusion:
Therefore, it is recommended that health managers and policymakers develop care and treatment plans by considering these risk factors.
Personal and Environmental Risk Factors of Work-Related Stress: A Cross-Sectional Study among Female Workers of a Textile Industry in Indonesia
Authors: Setyawan Haris , Denny Hanifa M. , Nurjazuli Nurjazuli , Dewi Endah Kumala 
Published: November 2022

Background:
In 2017, the prevalence of work-related stress reached 10.7% of the 792 million population. This work-related stress is common in the textile industry, characterized by many environmental risk factors coming from the weaving processes. The stress problem is discussed in various countries worldwide.

Objective:
The study aimed to investigate the personal and environmental risk factors for work-related stress in textile industry workers.

Methods:
This cross-sectional study was conducted in a textile factory weaving section in Solo, Indonesia. The subjects of this study were 188 female weaving operators that met the inclusion and exclusion criteria. The sound level meter was operated to measure the environmental noise, while environmental working conditions, work experience, social support, and work-related stress were measured using questionnaires. Furthermore, the Somers' Delta correlation was used to analyze the relationship between personal and environmental risk factors for work-related stress.

Results:
Surprisingly, this study found no significant correlation between personal and environmental risk factors (independent variables) with work-related stress (dependent variables). In personal factors, most of the workers are late adulthood (36-45 years old), the length of working dominated more than ten years (90.42%), with most of them having senior high school education (58.51%). In terms of environmental risk factors, most of the workers have good working environment conditions (51.6%); are well experienced in weaving tasks (54.3%), with a high social support category (58%).

Conclusion:
Although some previous studies indicated that personal factors, working conditions, and social support could trigger stress among workers, this study found no correlation between the independent and the dependent variables.
Patient Perspectives on Value Dimensions of Lung Cancer Care: Cross-sectional Web-Based Survey
Authors: Varriale Pasquale , Müller Borna , Katz Grégory , Dallas Lorraine , Aguaron Alfonso , Azoulai Marion , Girard Nicolas 
Published: November 2022

Background
While the lung cancer (LC) treatment landscape has rapidly evolved in recent years, easing symptom burden and treatment side effects remain central considerations in disease control.

Objective
The aim of this study was to assess the relative importance of dimensions of LC care to patients, and to explore the disease burden, including socioeconomic aspects not commonly covered in patient-reported outcomes instruments.

Methods
A questionnaire was sent to patients with LC and their caregivers to rate the value of a diverse set of quality of life dimensions in care, to evaluate communication between health care professionals (HCPs) and patients, and to explore the economic impact on respondents. The survey included questions on the dimensions of care covered by patient-reported outcomes instruments for quality-of-life evaluation (Functional Assessment of Cancer Therapy–Lung scale, EQ-5D, the European Organization for Research and Treatment of Cancer’s Core Quality of Life questionnaire, and the European Organization for Research and Treatment of Cancer’s Core Quality of Life in lung cancer 13-item questionnaire), as well as the International Consortium for Health Outcomes Measurement (ICHOM) standard set of patient-centered outcomes for LC. The survey respondents were participants on Carenity’s patient community platform, living either in France, the United Kingdom, Germany, Italy, or Spain.

Results
The survey included 150 respondents (115 patients and 35 caregivers). “Physical well-being” and “end-of-life care” (median scores of 9.6, IQR 7.7-10, and 9.7, IQR 8.0-10, on a 10-point scale) were rated highest among the different value dimensions assessed. “Physical well-being and functioning” was the dimension most frequently discussed with health care professionals (82/150, 55%), while only (17/100, 17%) reported discussing “end-of-life care.” After diagnosis, 43% (49/112) of patients younger than 65 years stopped working. Among respondents who indicated their monthly household income before and after diagnosis, 55% (38/69) reported a loss of income.

Conclusions
Our results showed the relevance of a broad range of aspects of care for the quality of life of patients with LC. End-of-life care was the dimension of care rated highest by patients with LC, irrespective of stage at diagnosis; however, this aspect is least frequently discussed with HCPs. The results also highlight the considerable socioeconomic impact of the disease, despite insurance coverage of direct costs.
Identifying Sleep Disorders From Search Engine Activity: Combining User-Generated Data With a Clinically Validated Questionnaire
Authors: Cohen Zion Mairav , Gescheit Iddo , Levy Nir , Yom-Tov Elad 
Published: November 2022

Background
Sleep disorders are experienced by up to 40% of the population but their diagnosis is often delayed by the availability of specialists.

Objective
We propose the use of search engine activity in conjunction with a validated web-based sleep questionnaire to facilitate wide-scale screening of prevalent sleep disorders.

Methods
Search advertisements offering a web-based sleep disorder screening questionnaire were shown on the Bing search engine to individuals who indicated an interest in sleep disorders. People who clicked on the advertisements and completed the sleep questionnaire were identified as being at risk for 1 of 4 common sleep disorders. A machine learning algorithm was applied to previous search engine queries to predict their suspected sleep disorder, as identified by the questionnaire.

Results
A total of 397 users consented to participate in the study and completed the questionnaire. Of them, 132 had sufficient past query data for analysis. Our findings show that diurnal patterns of people with sleep disorders were shifted by 2-3 hours compared to those of the controls. Past query activity was predictive of sleep disorders, approaching an area under the receiver operating characteristic curve of 0.62-0.69, depending on the sleep disorder.

Conclusions
Targeted advertisements can be used as an initial screening tool for people with sleep disorders. However, search engine data are seemingly insufficient as a sole method for screening. Nevertheless, we believe that evaluable web-based information, easily collected and processed with little effort on part of the physician and with low burden on the individual, can assist in the diagnostic process and possibly drive people to seek sleep assessment and diagnosis earlier than they currently do.
Systematic review of outcomes and patient heterogeneity in relapsed or refractory diffuse large B-cell lymphoma
Authors: Miller Sally D , Lozano-Ortega Greta , Mutebi Alex , Briggs Owanate , Sail Kavita , Elliott Brian , Kalsekar Anupama 
Published: November 2022

Aim:
To evaluate trials of systemic therapies in transplant-ineligible or -experienced, relapsed/refractory diffuse large-B cell lymphoma and the impact of patient characteristics on overall response rate (ORR).
Patients & methods:
Systematically reviewed multiple databases through 22 July 2021. Analyzed variations in patient characteristics and their relationship with ORR across trials.
Results:
Among 17 included trials, key patient characteristics varied substantially: primary refractory (0–69%), refractory to last line of therapy (LOT) (12–100%), ≥2 prior LOTs (14–100%), ≥3 prior LOTs (0–64%), IPI ≥3 (23–73%), tumor stage III/IV (50–90%) and median age (56–74 years). ORRs varied substantially (25–83%), correlating with these characteristics.
Conclusion:
Differences in patient characteristics significantly contribute to the variability in ORR across these trials and should be considered when contextualizing efficacy data.
DAMPAK PERUBAHAN TARIF PAJAK PENGHASILAN BADAN DAN PAJAK PERTAMBAHAN NILAI DI INDONESIA
Authors: Agustina Nadhif Zulfa , Hartono Djoni 
Published: November 2022

Penelitian ini bertujuan untuk menganalisis dampak perubahan tarif Pajak Penghasilan badan (PPh badan) dan Pajak Pertambahan Nilai (PPN) terhadap variabel ekonomi makro seperti PDB, konsumsi swasta, konsumsi pemerintah, dan investasi. Penelitian ini juga menganalisis dampak perubahan tarif PPh badan dan PPN terhadap pendapatan rumah tangga dan output per sektor. Penelitian ini melakukan simulasi dengan menggunakan model Computable General Equilibrium (CGE) dan data Sosial Accounting Matrix (SAM) 2019 sebagai database. Hasil simulasi menunjukkan bahwa pemotongan tarif Pajak Penghasilan badan sebesar 3% dan kenaikan tarif PPN dari sebesar 1% secara bersamaan akan meningkatkan konsumsi pemerintah dan investasi tetapi menurunkan konsumsi swasta, PDB, dan pendapatan rumah tangga baik di kelompok perdesaan maupun perkotaan dimana rumah tangga perdesaan mengalami penurunan pendapatan yang lebih besar. Kebijakan kenaikan tarif PPN memberikan dampak yang lebih kuat terhadap perekonomian. Sektor yang menunjukkan peningkatan output terbesar antara lain sektor adminstrasi pemerintahan, pertahanan, dan jaminan sosial wajib, jasa pendidikan, pertambangan dan penggalian, dan jasa kesehatan dan kegiatan sosial.
Refinements of Some Classical Inequalities Involving Sinc and Hyperbolic Sinc Functions
Authors: Bagul Yogesh J. , Thool Sumedh B. , Chesneau Christophe , Dhaigude Ramkrishna M. 
Published: November 2022

Abstract
Several bounds of trigonometric-exponential and hyperbolic-exponential type for sinc and hyperbolic sinc functions are presented. In an attempt to generalize the results, some known inequalities are sharpened and extended. Hyperbolic versions are also established, along with extensions.
Metode Inquiry Mempengaruhi Meningkatkan Kreativitas Belajar Makna Iman Kepada Kitab Allah Siswa Kelas II TPHP SUPM Negeri Ladong
Authors: Syauqi Muhammad 
Published: November 2022

Kreativitas belajar dapat ditiingkatkan melalui penerapan metode Inquiry suatu metode yang dapat membangun minat belajar siswa. Tujuan penelitian ini adalah untuk penerapan teori-teori baru dalam penerapan metode inquiry dalam mempelajari Makna Iman Kepada Kitab Allah yang dapat meningkatkan prestasi belajar siswa kelas II TPHP SUPM Negeri Ladong Tahun Pelajaran 2021/2022. Subjek penelitian ini adalah Siswa-siswi kelas II TPHP SUPM Negeri Ladong Tahun Pelajaran 2021/2022 berjumlah 20 orang siswa terdiri dari 10 orang laki-laki dan 10 orang perempuan. Prosedur penelitian melakukanplan,action, observation dan refleksi. Hasil penelitian Hasil tindakan siklus I peretmuan ke 1 nilai rata-rata pada pengamatan asepk afektif C, Aspek Kognitif 6,5 dan Aspek Psikomotor 6,3. Nilai ketuntasan belajar mencapai 25%. Pertemuan ke 2 maka nilai rata-rata pada aspek afektif C aspek kognitif 6,75 dan aspek psikomotor 6,65. Nilai ketuntasan belajar mencapai 50%. Siklus II pertemuan ke 1 nilai rata-rata pada aspek afektif C, aspek kognitif 7.1 dan aspek psikomotor 6,95. Untuk nilai ketuntasan belajar mencapai 65%. Pertemuan ke 2 nilai rata-rata aspek afektif B, aspek kognitif 7,4 dan aspek psikomotor 7,2 nilai ketuntasan belajar mencapai 80%.
Penerapan Model Tipe Make A Match Mempelajari Materi Riba dapat Meningkatkan Nilai Siswa MTSN 3 Pidie Jaya
Authors: Julia Julia 
Published: November 2022

Proses belajar mengajar menggunakan model Tipe Make A Match dalam mempelajari materi riba dalam ilmu fiqih dapat meningkatkan nilai belajar siswa kelas IX MTsN Pidie Jaya. Tujuan penelitian ini adalah untuk mengetahui pengembangan teori-teori baru dalam penerapan model Tipe Make A Match dalam mempelajari materi Riba dan dapat meningkatkan nilai belajar siswa kelas IX-B MTsN 3 Pidie Jaya Tahun Pelajaran 2020/2021. Subjek penelitian adalah Siswa siswi kelas IX-B MTsN 3 Pidie Jaya Tahun Pelajaran 2020/2021 yang berjumlah 15 orang siswa, yang terdiri dari 7 orang siswa laki-laki dan 8 orang siswa perempuan. Prosedur penelitian melakukan plan, action, observation dan reflex ion hasil penelitian Hasil tindakan siklus I pertemuan ke 1 bahwa nilai rata-rata pada aspek afektif C, aspek kognitif 6,73, aspek psikomotor 6,19 dan nilai ketuntasan belajar secara klasikal mencapai 40%. Pertemuan ke 2 nilai rata-rata pada aspek afektif C, aspek kognitif 7,00, aspek psikomotor 6,38. Nilai ketuntasan belajar siswa mencapai 55,33%. Hasil tindakan siklus II pertemuan ke 1 nilai rata-rata pada aspek afektif B, aspek kognitif 7,27 dan aspek psikomotor 6,63. Untuk nilai ketuntasan belajar mencapai 66,67 %. Pertemuan ke 2 rata-rata nilai pada aspek afektif B, aspek kognitif 7,60 dan aspek psikomotor 7,31 untuk nilai ketuntasan belajar secara klasikal mencapai 80%.