bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grundlagen medikamentös-induzierter Polyneuropathien
Authors: Achenbach Pascal , Block Frank , Dafotakis Manuel 
Published: September 2022

ZusammenfassungZahlreiche Wirkstoffe können mit dem erstmaligen Auftreten oder dem Fortschreiten neuropathischer Symptome in Verbindung gebracht werden. Insbesondere im Kontext der modernen Polypharmazie kommt medikamentös-induzierten Polyneuropathien eine besondere Bedeutung zu. Die Schädigungsmechanismen und individuellen Risikofaktoren sind vielfältig. In den meisten Fällen resultiert eine längenabhängige, axonale Polyneuropathie mit vorwiegend sensiblen Symptomen. Grundlegende Kenntnisse darüber, welche Arzneimittel mit dem Auftreten einer Polyneuropathie assoziiert sind, können dazu beitragen, das Auftreten dieser Nebenwirkung frühzeitig zu erkennen. Die Verordnung entsprechender Medikamente sollte vermieden werden, wenn das Risiko für den einzelnen Patienten als zu hoch eingeschätzt wird. Unter Therapie sind regelmäßige Kontrolluntersuchungen nötig, um bei neuauftretenden oder zunehmenden Symptomen die Therapie so früh wie möglich anpassen oder absetzen zu können. Die Prognose ist dann meist gut.
Geriatric Nutritional Risk Index and the Prognosis of Patients with
Stroke: A Meta-Analysis
Authors: Hu Jun , Chen Ting , Wang Ziyue , Chen Xuhui , Lin Kaihua , Zhang Guogao , Wu Jun 
Published: September 2022

AbstractMalnutrition evidenced by low geriatric nutritional risk index (GNRI) has been
suggested as a potential predictor of poor prognosis of patients with various
clinical conditions. We performed a meta-analysis to systematically assess the
association between GNRI and the prognosis of patients after stroke. Cohort
studies were identified by search of PubMed, Embase, Cochrane’s Library
and Web of Science databases from inception to March 25, 2022, according to the
aim of the meta-analysis. A random-effect model incorporating the potential
between-study heterogeneity was used to pool the results. Eight cohort studies
with 13573 patients with stroke contributed to the meta-analysis. Pooled results
showed that malnutrition as evidenced by low GNRI was independently associated
with a higher risk of poor functional outcome [risk ratio (RR): 1.54,
95% confidence interval (CI): 1.19 to 1.98, p<0.001;
I2=69%] and an increased incidence of all-cause mortality (RR:
1.82, 95% CI: 1.35 to 2.47, p<0.001; I2=74%).
Sensitivity analyses showed consistent results in patients with ischemic stroke,
and in prospective cohort studies. Subgroup analyses showed that the
associations were not significant for patients with GNRI-defined mild
malnutrition (p=0.18 and 0.20 for functional and mortality outcomes,
respectively), but significant for patients with moderate-severe malnutrition
(both p<0.001). Difference in follow-up durations did not significantly
affect the associations (p for subgroup difference=0.75 and 0.70,
respectively). In conclusion, a low GNRI is associated with poor functional and
survival outcomes in patients after stroke.
Homocysteine and the Mortality of Critically Ill Patients: A
Meta-Analysis
Authors: Yuan Fawei , Zheng Kun 
Published: September 2022

AbstractPrevalence of hyperhomocysteinemia (HHcy) is high in critically ill patients.
However, the association between serum homocysteine level and outcomes of the
critically ill patients remains unknown. We performed a meta-analysis of cohort
studies to comprehensively evaluate the above association. Relevant cohort
studies were identified by search of electronic databases including PubMed,
Embase, Web of Science, Wanfang, and CNKI from the inception of the databases to
February 5, 2022. A randomized-effect model incorporating the possible
between-study heterogeneity was used to pool the results. Overall, 16 cohorts
with 1663 critically ill patients who were admitted to the intensive care unit
(ICU) were involved in the meta-analysis. Pooled results showed that compared to
non-survivors of the critical illnesses, survivors had significantly lower serum
level of Hcy at ICU admission [mean difference (MD): –3.42
μmol/l, 95% confidence interval (CI): –5.89 to
0.94, p=0.007; I2=86%]. Subgroup analysis showed that
the difference of Hcy between survivors and non-survivors was significant in
Asian patients (MD: –8.17 μmol/l, p<0.001), but
not in non-Asians (MD: 0.30 μmol/l, p=0.62; p for
subgroup difference<0.001). Moreover, meta-analysis with seven cohorts,
all including Chinese patients, showed that HHcy at ICU admission was
independently associated with a higher risk of all-cause mortality in critically
ill patients (odds ratio: 2.99, 95% CI: 2.26 to 3.97, p<0.001;
I2=69%). A higher serum level of Hcy at ICU admission may be
associated with an increased risk of all-cause mortality in critically ill
patients, particularly in the Chinese population.
Can We Predict Feto-Maternal Adverse Outcomes of Vacuum Extraction?
Authors: Cohen Gal , Schreiber Hanoch , Shalev Ram Hila , Ovadia Michal , Shechter-Maor Gil , Biron-Shental Tal 
Published: September 2022

Abstract
Introduction Vacuum extraction (VE) is an important modality in modern obstetrics, yet sometimes results in maternal or neonatal adverse outcomes, which can cause a lifetime
disability. We aimed to characterize potential risk factors for adverse outcomes that in retrospect would have led the physician to avoid the procedure.
Materials and Methods Retrospective cohort of 3331 singleton pregnancies, ≥ 34 w delivered by VE. 263 deliveries (7.9%) incurred a VE-related feto-maternal adverse outcome, defined
as one or more of the following: 3–4th-degree perineal laceration, subgaleal hematoma, intracranial hemorrhage, shoulder dystocia, clavicular fracture, Erb’s palsy or fracture of humerus.
3068 deliveries (92.1%) did not have VE-related adverse outcomes. Both groups were compared to determine potential risk factors for VE adverse outcomes.
Results Multivariable regression found seven independent risk factors for VE-related feto-maternal adverse outcomes: Nulliparity – with an odds ratio (OR) of 1.82 (95%
CI = 1.11–2.98, p = 0.018), epidural anesthesia (OR 1.99, CI = 1.42–2.80, p < 0.001), Ventouse-Mityvac (VM) cup (OR 1.86, CI = 1.35–2.54, p < 0.001), prolonged second stage as
indication for VE (OR 1.54, CI = 1.11–2.15, p = 0.010), cup detachment (OR 1.66, CI = 1.18–2.34, p = 0.004), increasing procedure duration (OR 1.07 for every additional minute,
CI = 1.03–1.11, p < 0.001) and increasing neonatal birthweight (OR 3.42 for every additional kg, CI = 2.33–5.02, p < 0.001). Occiput anterior (OA) position was a protective factor (OR
0.62, CI = 0.43–0.89, p = 0.010).
Conclusions VE-related adverse outcomes can be correlated to clinical characteristics, such as nulliparity, epidural anesthesia, VM cup, prolonged second stage as indication for VE,
cup detachment, prolonged procedure duration and increasing neonatal weight. OA position was a protective factor. This information may assist medical staff to make an informed decision
whether to choose VE or cesarean delivery (CD).
Skaphoidfrakturen und -pseudarthrosen: Unsere Wahl des
Zugangs
Authors: Prommersberger Karl-Josef , Dimitrova Polina , Kalb Karlheinz , Mühldorfer-Fodor Marion 
Published: September 2022

ZusammenfassungDie vorliegende Arbeit beschreibt unsere bevorzugten Zugänge für
die operative Versorgung von Kahnbeinfrakturen und Kahnbeinpseudarthrosen.
Effects of Essential Oils on Scars and Wound Healing: A Systematic Review
Authors: Wang James C. , Fort Callie L. , Matl Christina M. , Harvey Bailey D. , Demke Joshua C. , Thomas J Regan , Sidle Douglas M. 
Published: September 2022

AbstractEssential oils (EOs) have been considered as a potential alternative therapy for wound healing and scar reduction. The aim of this article was to provide a comprehensive review examining the effects of EOs on wound healing and scars. PubMed, Cochrane, Ovid, and Embase computerized searches were performed through June 2020. Two independent reviewers conducted data extraction, with search results reviewed by the senior author following the PRISMA protocol. Three manuscripts examining three different EO-containing topical agents were analyzed. Outcomes include healing rate, erythema, pain, pruritus, patient discomfort, physician satisfaction, percent wound reduction, wound/scar surface perimeter area, and qualitative dermatological evaluation. All articles concluded that the EO-containing topical agents resulted in either superior or noninferior outcomes in comparison with controls. Hypericum–Calendula oil obtained lower wound surface perimeter area. Erythema (p = 0.001) was significantly decreased by the peppermint EO–containing topical agent. Physicians also reported greater satisfaction (p < 0.001) in wound appearance with use of the peppermint EO–containing topical agent. A paucity of studies have examined EO use for wound healing and scar reduction. Treatment with EO-containing topical agents resulted in decreased erythema with increased physician satisfaction of wound appearance. Future studies should assess what level of purity is needed for improved results and which EO, or combination of EOs, is most beneficial.
One Digital Health for more FAIRness
Authors: Tamburis Oscar , Benis Arriel 
Published: September 2022

Abstract
Background One Digital Health (ODH) aims to propose a framework that merges One Health's and Digital Health's specific features into an innovative landscape. FAIR (Findable, Accessible, Interoperable, and Reusable) principles consider applications and computational agents (or, in other terms, data, metadata, and infrastructures) as stakeholders with the capacity to find, access, interoperate, and reuse data with none or minimal human intervention.
Objectives This paper aims to elicit how the ODH framework is compliant with FAIR principles and metrics, providing some thinking guide to investigate and define whether adapted metrics need to be figured out for an effective ODH Intervention setup.
Methods An integrative analysis of the literature was conducted to extract instances of the need—or of the eventual already existing deployment—of FAIR principles, for each of the three layers (keys, perspectives and dimensions) of the ODH framework. The scope was to assess the extent of scatteredness in pursuing the many facets of FAIRness, descending from the lack of a unifying and balanced framework.
Results A first attempt to interpret the different technological components existing in the different layers of the ODH framework, in the light of the FAIR principles, was conducted. Although the mature and working examples of workflows for data FAIRification processes currently retrievable in the literature provided a robust ground to work on, a nonsuitable capacity to fully assess FAIR aspects for highly interconnected scenarios, which the ODH-based ones are, has emerged. Rooms for improvement are anyway possible to timely deal with all the underlying features of topics like the delivery of health care in a syndemic scenario, the digital transformation of human and animal health data, or the digital nature conservation through digital technology-based intervention.
Conclusions ODH pillars account for the availability (findability, accessibility) of human, animal, and environmental data allowing a unified understanding of complex interactions (interoperability) over time (reusability). A vision of integration between these two worlds, under the vest of ODH Interventions featuring FAIRness characteristics, toward the development of a systemic lookup of health and ecology in a digitalized way, is therefore auspicable.
Transition-Metal-Free Synthesis of 3-Ethynylcoumarins by a DBU-Promoted Intramolecular Morita–Baylis–Hillman-Type Reaction/Dehydration/Isomerization Cascade
Authors: Dai Shuolu , Gu Xiaoyu , Wang Zhen , Yao Weijun 
Published: September 2022

AbstractA transition-metal-free synthesis of 3-ethynylcoumarins from salicylaldehyde-derived alkynoates was developed involving a DBU-promoted intramolecular Morita–Baylis–Hillman-type reaction/dehydration/isomerization cascade. A wide variety of alkynoates were employed to deliver 3-ethynylcoumarins in moderate to good yields.
Flexor Tenosynovitis Caused by Neisseria gonorrhea Infection: Case Series, Literature Review, and Treatment Recommendations
Authors: Jain Nirbhay , Saadat Sean , Goldberg Mytien 
Published: September 2022

AbstractNeisseria gonorrhoeae is the most common sexually transmitted disease in the world and is known to cause disseminated disease, most commonly tenosynovitis. Classically, gonorrhea-associated tenosynovitis presents with concomitant dermatitis and arthralgias, though this is not always the case. N. gonorrhoeae-related tenosynovitis has become more commonly seen by hand surgeons. To aid in management, we present three cases of gonorrhea-induced tenosynovitis spanning a range of presentations with variable treatments to demonstrate the variety of patients with this disease. Only one of our patients had a positive gonococcal screening test and no patient had purulent urethritis, the most common gonorrhea-related symptom. A separate patient had the classic triad of tenosynovitis, dermatitis, and arthralgias. Two patients underwent operative irrigation and debridement, and one was managed with anti-gonococcal antibiotics alone. Though gonorrhea is a rare cause of flexor tenosynovitis, it must always be on the differential for hand surgeons when they encounter this diagnosis. Taking an appropriate sexual history and performing routine screening tests can assist in the diagnosis, the prescription of appropriate antibiotics, and potentially avoiding an unnecessary operation.
Increased Postoperative Pseudosubluxation after Total Hip Arthroplasty: A Complication Accelerated by the COVID-19 Pandemic
Authors: Sun Daniel C. , Bono James V. 
Published: September 2022

AbstractThe severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019) has accelerated the utilization of spinal anesthesia for total hip arthroplasty. Subsequently, an increase in postoperative prosthetic subluxation has been noted at our institution. We report on our experience with this complication in six patients. We also reviewed the literature for similar cases and potential risk factors. This complication may be treated by either closed reduction or watchful waiting. However, no modifications to postoperative protocols are necessary.
Integration of Risk Scores and Integration Capability in Electronic Patient Records
Authors: Heider Ann-Kathrin , Mang Harald 
Published: September 2022

Abstract
Background Digital availability of patient data is continuously improving with the increasing implementation of electronic patient records in physician practices. The emergence of digital health data defines new fields of application for data analytics applications, which in turn offer extensive options of using data. Common areas of data analytics applications include decision support, administration, and fraud detection. Risk scores play an important role in compiling algorithms that underlay tools for decision support.
Objectives This study aims to identify the current state of risk score integration and integration capability in electronic patient records for cardiovascular disease and diabetes in German primary care practices.
Methods We developed an evaluation framework to determine the current state of risk score integration and future integration options for four cardiovascular disease risk scores (arriba, Pooled Cohort Equations, QRISK3, and Systematic Coronary Risk Evaluation) and two diabetes risk scores (Finnish Diabetes Risk Score and German Diabetes Risk Score). We then used this framework to evaluate the integration of risk scores in common practice software solutions by examining the software and inquiring the respective software contact person.
Results Our evaluation showed that the most widely integrated risk score is arriba, as recommended by German medical guidelines. Every software version in our sample provided either an interface to arriba or the option to implement one. Our assessment of integration capability revealed a more nuanced picture. Results on data availability were mixed. Each score contains at least one variable, which requires laboratory diagnostics. Our analysis of data standardization showed that only one score documented all variables in a standardized way.
Conclusion Our assessment revealed that the current state of risk score integration in physician practice software is rather low. Integration capability currently faces some obstacles. Future research should develop a comprehensive framework that considers the reasonable integration of risk scores into practice workflows, disease prevention programs, and the awareness of physicians and patients.
Individual adsorption of low volatility pheromones: Amphiphilic molecules on a clean water–air interface
Authors: Jami L. , Zemb T. , Casas J. , Dufrêche J-F. 
Published: September 2022

Environmental conditions can alter olfactory scent and chemical communication among biological species. In particular, odorant molecules interact with aerosols. Thermodynamics variables governing the adsorption from air to water surface of bombykol, the most studied pheromone, and of three derivative molecules, bombykal, bombykoic acid, and bombykyle acetate, are computed by steered and un-biased molecular dynamics in order to compare the role of their polar head group on adsorption on aqueous aerosols. When adsorbed, the molecule center of mass stands at about 1.2 Å from the interface and oscillates on the same length scale, trapped in an energy well. Gibbs energy of adsorption and desorption time of bombykol are found to be 9.2 kBT and 59 µs, respectively. The following ordering between the molecules is observed, reading from the more to the least adsorbed: bombykoic acid &gt; bombykol &gt; bombykoic acetate &gt; bombykal. It originates from a complex interplay of entropy and enthalpy. The entropy and enthalpy of adsorption are discussed in the light of structural arrangement, H-bonding, and hydrophilic tail positioning of the molecules at the interface. Our results show that, when dispersed in the air, pheromones adsorb on aqueous aerosols. However, the individual residence time is quite short on pure water surfaces. Aerosols can, therefore, only have a decisive influence on chemical communication through collective effects or through their chemical composition that is generally more complex than that of a pure water surface.
Tetrahedral omnidirectional full-tensor gravitational wave detector
Authors: Metzler Zachary , Collins Christopher J , Paik Ho Jung , Shawhan Peter S 
Published: September 2022

Abstract
We propose a new tetrahedral configuration of three-axis inertial sensors, whose signals when combined create an isotropic sensitivity to gravitational waves. This arrangement provides total sky coverage and full-tensor measurements of the gravity gradient using only four test masses (TMs), compared to the six TMs of the previously studied TIGA and superconducting omnidirectional gravitational radiation observatory designs. Since weakly suspending a TM in all three directions is difficult due to the gravity bias, we also present the directional sensitivity plot for the case where only horizontal displacements are measured. This antenna pattern is no longer isotropic, and results in a maximum sensitivity to minimum sensitivity ratio of 2:1 in power. The full gravity gradient tensor can in this case still be reconstructed if the platform is sufficiently isolated from ground tilt.
Regularization theory of the analytic deep prior approach
Authors: Arndt Clemens 
Published: September 2022

Abstract
The analytic deep prior (ADP) approach was recently introduced for the theoretical analysis of deep image prior (DIP) methods with special network architectures. In this paper, we prove that ADP is in fact equivalent to classical variational Ivanov methods for solving ill-posed inverse problems. Besides, we propose a new variant which incorporates the strategy of early stopping into the ADP model. For both variants, we show how classical regularization properties (existence, stability, convergence) can be obtained under common assumptions.
Atom-assisted coherent control of multiple-color mechanically induced switching
Authors: Ghafoor Fazal , Akram Muhammad Javed , Ayaz Muhammad , Kokab Hassana , Saif Farhan 
Published: September 2022

Abstract
We show multiple mechanically induced switching of a weak probe field through a system of cavity-optomechanics with a medium of N number of three levels (Λ-type) atoms exhibiting a strong coherent field coupling. Three distinct MIT windows develop for the probe field transmission using optomechanical coupling together with two other coupling parameters related to the two atomic transitions. Adjustment of the relative phase associated with the coupling parameters leads to multiple absorption-induced optical switching. The switching is obtained by closing one through three of the MIT windows for the probe field transmission tuning the relative phase and vice versa. Contrary to the multiple mechanical induced transparency, the optical switching phenomenon is explained regarding constructive quantum interference effect in the system.
Resonant terahertz excitation and radiation from hierarchically-structured ZnO microspheres via a cylindrical cavity
Authors: Guan Sitao , Wang Yixian , Wu Jingbo , Lyu Yangyang , Zhang Zhiyong , Chen Jian , Wang Huabing , Wu Xinglong 
Published: September 2022

Abstract
High-efficiency terahertz (THz) emission and detection are of great interest because of their promising applications in high-speed communications, biomedicine, and imaging. A previous study has achieved efficient room-temperature THz emission at ∼360 GHz by green-light exciting the lattice symmetric stretching vibrations of ZnO nanoplates self-assembled into ZnO microspheres (MSs). Herein, we explore resonant THz radiation of this kind of ZnO MSs under around 360 GHz excitation. A Fabry–Perot resonant cavity is designed and used to obtain the resonant THz signal. Compared to the case without the ZnO MSs, the THz output powers are enhanced by 1.5 and 3.2 times under two excitations of 356.1 and 375.8 GHz with an input power of 6.5 mW, respectively. Furthermore, it is shown that when a wide frequency THz wave irradiates on the ZnO MSs in the cavity, the output THz signal strength shows an obvious variation with frequency and can thus be utilized to detect the presence of some THz waves with specific frequencies. This work indicates that such self-assembled MSs can not only radiate the enhanced THz waves via a resonator, but also effectively apperceive some specific THz signals as a detector.