bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Stem Cells to Treat Diabetes-Induced Infertility
Authors: Abedini Fatemeh , Giassi Fariba , Rahbarghazi Reza , Hamidian Golamreza , Keyhanmanesh Rana 
Published: November 2022

Abstract:
Diabetes is one of the main causes of infertility, which impacts the quality of life of
couples. These reproductive complications are important issues for all clinicians. The strategies for
the treatment of diabetes-induced infertility are limited with the high cost and unsatisfied results.
Due to the multi-directional differentiation potential and self-renewal ability of stem cells, these
cells have emerged as attractive therapeutic agents in many diseases, including diabetes mellitus.
We reviewed the current knowledge on the best available evidence regarding the role of stem cell
transplantation in reproductive complications of diabetes.
Reciprocal Interaction of Pain and Brain: Plasticity-induced Pain,
Pain-induced Plasticity, and Therapeutic Targets
Authors: Kourosh-Arami Masoumeh , Komaki Alireza 
Published: November 2022

Abstract:
Considerable functional and structural alterations, or plasticity, in the central nervous system
(CNS) are accompanied by numerous chronic pain syndromes. Sensitization of the peripheral
(primary hyperalgesia) or central (secondary hyperalgesia) nervous system as unhelpful neuroplasticity
may result in stimulus-induced pain (hyperalgesia and allodynia). Furthermore, nociception induces
extensive plasticity in the peripheral and central neural systems in pathological disease states. Diseaseinduced
plasticity at both structural and functional levels is evident as alterations in different molecules,
synapses, cellular function and network activity. In the present article, we review plasticityinduced
pain and pain-induced plasticity. Moreover, we will review the pain matrix. Furthermore, we
will focus on recent developments of CNS alterations in long-lasting pain in some clinical entities encountered
in rehabilitation. These clinical entities comprise nonspecific low back pain, complex regional
pain syndrome, postamputation phantom pain, fibromyalgia, and chronic pain after spinal cord
injury. Moreover, we will review the clinical treatment for the inhibition of pathological pain.
Low-dose Aspirin may Prevent Preeclampsia by Inhibiting the Expression
of ATF2
Authors: Xiao Sha , Guo Lu , Zhang Ming , Hu Rong , Liu Rong 
Published: November 2022

aims:
To explore the ATF2 expression of preeclampsia patients and investigate whether the level of ATF2 expression impacted the low-dose aspirin treatment of preeclampsia patients.

background:
Preeclampsia is a severe pregnancy-related hypertension disorder and refers to hypertension.

objective:
To explore the ATF2 expression of preeclampsia patients and investigate whether the level of ATF2 expression impacted the low-dose aspirin treatment of preeclampsia patients.

method:
Firstly, we collected the plasma of normal and preeclampsia pregnancies and quantified the expressions of ATF2 by ELISA. Then we quantified the expression of the three downstream target genes of ATF2 (IL-8, IL-6 and MMP-2). Finally, we collected and quantified the interventional and observational group plasma, which were different from LDA administration. All data were compared by t-test (P&amp;lt;0.05).

result:
ATF2 and its target genes (IL-6, IL-8 and MMP-2) were upregulated in preeclampsia patients. In addition, ATF2 and its target genes were downregulated in the interventional group.

conclusion:
Our results indicated that LDA could inhibit ATF2 expression in preeclampsia. It suggests that ATF2 may be a potential target of LDA in the prevention of preeclampsia.

other:
None.
Optimization of Carotenoid Production by Rhodosporidium babjevae and
Evaluation of Antifungal and Dyeing Activity
Authors: Salimi Nastaran , Madani Mahboobeh , Shakib Pegah 
Published: November 2022

Aims and Objective:
The aim of this study was to evaluate the antifungal, dyeing activity
and optimization of carotenoid production by Rhodosporidium babjevae.

Background:
Rhodosporidium red yeast is one of the natural alternative sources of carotenoids.
Carotenoids are produced by a wide variety of bacteria, algae, fungi ,and plants. These pigments serve
a vital function as antioxidant protectors and have lately caught a lot of attention because of their
positive impact on human health.

Methods:
In this experimental-laboratory study, Rhodosporidium was isolated from different environmental
sources in Isfahan. After carotenoid extraction based on the Davis method from Rhodosporidium,
cell biomass, and the total amount of carotenoids were measured, and the carotenoid light absorption
spectrum was determined. To optimize carotenoid production, one-factor and Taguchi methods
evaluated incubation time factors, pH, nitrogen, and carbon source. Then, yeast carotenoid antifungal
activity, minimum inhibitory concentration (MIC),and minimum fungicidal concentration
(MFC) were determined. The stability of dye against washing, rubbing, and light was investigated to
evaluate the carotenoid dyeing activity.

Results:
The optimum condition for carotenoid production was 96 hours of incubation, 2 g L-1
peptone, pH 5.5, and 30 g L-1 glucose. The optimal conditions of Taguchi were performed, and
production of 11.67 mg L-1 was obtained. The carotenoid pigment isolated from Rhodosporidium
babjevae showed no anti-candida properties but has antifungal activity against A. flavus and A. niger.
Woolen fabric had washing fastness of 2 and cotton fabric had a washing fastness of 3. The staining
grade on woolen and cotton fabrics was 4. The grade of color fastness of woolen and cotton fabrics
against dry rubbing was 5, while the grade of color fastness against wet rubbing was 2 and 4,
respectively.

Conclusion:
Based on the results, Rhodosporidium babjevae carotenoid is a suitable option for dyeing
woolen and cotton fabrics with antifungal properties that can be used in industry. It is hoped that it can
be used for the commercial production of carotenoids.
Crowbar Protection and Blades Pitch Angle Control of a Wind Turbine at
Severe Faulty Conditions using Adaptive Neuro-Fuzzy Inference System
Authors: Safwat Ayman , Bahgat Mohiy El-Sayed. , Abdel-Ghany Abdel-Ghany Muhammad , El Zoghby Helmy Mohammad 
Published: November 2022

Background:
Due to their superior efficiency, stability, and ability to produce maximum
power under various typical operating situations, wind turbines driving doubly fed induction generator
systems are frequently utilized in wind power extraction. These systems face stability problems
especially at severe faulty conditions.

Objective:
To protect the rotating parts of the system from over speeding when the fault occurs and
to ensure that the generator does not deviate from stability by adjusting the aerodynamic torque of
the wind turbine. In addition, to protect electrical parts of the system, especially DC bus voltage and
power electronics converters.

Methods:
Using Adaptive Neuro-Fuzzy Inference System (ANFIS). The proposed ANFIS technique
detects the faulty conditions from the measured voltages and currents at the terminals of the generator.
In case of faulty cases, an ANFIS technology activates the wind turbine's pitch angle controller
and the crowbar resistance.

Results:
A comparison between the behavior of DFIG at faulty conditions without any fault controller
and with the proposed ANFIS technique is applied. When the ANFIS technique is used, the wind
system's performance and response are improved.

Conclusion:
The proposed ANFIS control system has proven its effectiveness in protecting the
DFIG in the event of a grid fault.
Comparative economic outcomes in patients with focal seizures initiating eslicarbazepine acetate versus brivaracetam in the long-term care setting in the USA
Authors: Mehta Darshan , Lee Inyoung , Liu Hangcheng , DeKoven Mitchell , Wensel Brian , Williams G. Rhys 
Published: November 2022

Aim:
To compare all-cause and epilepsy-specific pharmacy and total costs associated with initiation of eslicarbazepine acetate (ESL) or brivaracetam (BRV) among patients with focal seizures in long-term care (LTC) in the US.
Methods:
This retrospective analysis used data from IQVIA's New Data Warehouse.
Results:
298 patients initiated ESL and 282 patients initiated BRV. Initiation of ESL versus BRV was associated with 33.3% lower all-cause pharmacy costs, 34.4% lower epilepsy-specific pharmacy costs, 21.3% lower all-cause total costs and 30.9% lower epilepsy-specific total costs (all p < 0.0001).
Conclusion:
Among patients with focal seizures in LTC in the US, initiation of ESL versus BRV was associated with significant reductions in all-cause and epilepsy-specific pharmacy and total costs compared with initiation of BRV.
Discrecionalidad y ponderación en la creación y uso de parámetros de adjudicación en el proceso licitatorio
Authors: Arriagada Zeta Felipe Antonio 
Published: November 2022

The relationship of the bidding bases as decisions and the areas of discretion that the Administration possesses is addressed, through a review of the decision-making process involved in the creation and use of award parameters in the bidding procedure. A comprehensive concept of discretion is elaborated of all its elements, to then address the manifestations of administrative discretion in the preparation and subsequent application of the bidding conditions, thus studying the decision-making process and determining that the bases have a double character in relation to administrative discretion. On the one hand, they are a manifestation of strong administrative discretion when considering principles to create the rule that the bidding implies; and on the other hand, they are a limitation to administrative discretion, since they increase the programmatic density and determines that the Administration acts with instrumental administrative discretion when applying the bidding rules.
Religious Heritage and Values Perfecting Peacefulness Among the Contemporary Yorùbá
Authors: Olayinka Akintayo Sunday 
Published: November 2022

This paper presents the roles that religious heritage among the Yorùbá
plays in sustaining their peacefulness. The Yorùbá use both formal and
informal interactions to engage one another in discourses that enhance
their togetherness but often faced with outside influences that can
truncate their desired goals. This paper, therefore, places the Yorùbá
by the established peaceful societies (PS) to see how they compare in
their attitude to peacefulness and providing explanation to the Yorùbá’s
effort to keep the peace despite the outside influences on their
society.
Please note: The bulk of this article is taken from chapter 8
of the author’s doctoral dissertation with a few amendments to suit this
journal.
Keywords: Christian-Muslim relations, peace studies, Africa -
Yorùbá, religious – ethics, culture – values, Covid-19.
Religious Hermeneutic as a Means of Sustaining Peace
Authors: Olayinka Akintayo Sunday 
Published: November 2022

This paper presents the roles the interpretations of religion (or texts)
and understanding of religion play in the sustainability of peace among
the Yorùbá people of southwest Nigeria. The Yorùbá’s way of interacting
and practising religion has remained moderately amiable over the last
two centuries when compared with other communities in Nigeria. With
attention on Yorùbá Christians and Muslims, this author examines some
specific religious concepts and values that have been useful in guiding
the two religions to retain their peace or return to dialogue table to
refrain from violence and keep the peace. The paper argues that the
interpretations of some religious terms and values among the Yorùbá
enhance their pursuance of peace.
Please note: The bulk of this article is taken from chapter 8
of the author’s doctoral dissertation with a few amendments to suit this
journal.
Low-Dose Empagliflozin as Adjunct to Hybrid Closed-Loop Insulin Therapy in Adults With Suboptimally Controlled Type 1 Diabetes: A Randomized Crossover Controlled Trial
Authors: Pasqua Melissa-Rosina , Jafar Adnan , Kobayati Alessandra , Tsoukas Michael A. , Haidar Ahmad 
Published: November 2022

OBJECTIVE
To assess whether low doses of empagliflozin as adjunct to hybrid closed-loop therapy improve glycemia compared with placebo in adults with type 1 diabetes (T1D) who are not able to achieve targets with the system alone.

RESEARCH DESIGN AND METHODS
A double-blind crossover randomized controlled trial was performed in adults with suboptimally controlled T1D (HbA1c 7.0–10.5%) who were not able to achieve a target time in range (3.9–10.0 mmol/L) ≥70% after 14 days of hybrid closed-loop therapy. Three 14-day interventions were performed with placebo, 2.5 mg empagliflozin, or 5 mg empagliflozin as adjunct to the McGill artificial pancreas. Participants were assigned at a 1:1:1:1:1:1 ratio with blocked randomization. The primary outcome was time in range (3.9–10.0 mmol/L). Analysis was by intention to treat, and a P value &lt;0.05 was regarded as significant.

RESULTS
A total of 24 participants completed the study (50% male; age 33 ± 14 years; HbA1c 8.1 ± 0.5%). The time in range was 59.0 ± 9.0% for placebo, 71.6 ± 9.7% for 2.5 mg empagliflozin, and 70.2 ± 8.0% for 5 mg empagliflozin (P &lt; 0.0001 between 2.5 mg empagliflozin and placebo and between 5 mg empagliflozin and placebo). Mean daily capillary ketone levels were not different between arms. There were no serious adverse events or cases of diabetic ketoacidosis or severe hypoglycemia in any intervention.

CONCLUSIONS
Empagliflozin at 2.5 and 5 mg increased time in range during hybrid closed-loop therapy by 11–13 percentage points compared with placebo in those who otherwise were unable to attain glycemic targets. Future studies are required to assess long-term efficacy and safety.
Pelatihan Teknik Budidaya Pohon Ketapang Kencana pada Kelompok Masyarakat RT/RW Kelurahan Ngade
Authors: Nurdin Aqshan Shadikin , Irmayanti Laswi , Nurhikmah Nurhikmah 
Published: November 2022

Pesatnya pembangunan perumahan di kota ternate membuat kondisi lingkungan mengalami perubahan, Sebagian besar lahan di wilayah Kelurahan Ngade digunakan untuk perumahan. Lahan ini merupakan titik pokok perhatian dihubungkan dengan masalah pengendalian erosi disebabkan kondisi lahannya, letaknya pada lereng-lereng yang curam sampai sangat curam akan tetapi masih memiliki peluang untuk dilakukan kegiatan pengkayaan tanaman (enrichment planting). Pohon Ketapang Kencana (Terminalia mantaly.) memiliki tajuk yang rindang serta indah sehingga baik untuk ditanam di halaman rumah, di daerah berlereng atau di sepanjang tepi jalan. Salah satu konsep yang dapat diterapkan untuk mengatasi permasalahan diatas, yaitu dengan penerapan konsep hutan kota dalam perencanaan tata ruang kota. Penerapan konsep hutan kota dalam perencanaan tata kota merupakan cara yang efektif dan efisien untuk mengatasi masalah menurunnya kualitas lingkungan hidup perkotaan. Sasaran dari Program kemitraan Masyarakat adalah masyarakat di sekitar wilayah kelurahan Ngade Kota Ternate. Kelompok masyarakat yang menjadi sasaran program ini yaitu masyarakat yang tergabung dalam RT dan RW di kelurahan Ngade. Kegiatan Pengabdian kepada Masyarakat berupa pelatihan Budidaya tanaman ketapang kencana memberikan kontribusi postif dalam pelestarian lingkungan khususnya di kelurahan Ngade. Sebagian besar warga yang terlibat dalam kegiatan ini merasakan pengalaman baru dalam membudidayakan tanaman ketapang kencana.
ANALISIS PERBANDINGAN METODE FULL COSTING DAN VARIABEL COSTING DALAM PENETAPAN HARGA POKOK PRODUKSI (STUDI PADA PERUSAHAAN DAERAH AIR MINUM TIRTA JE’NEBERANG KABUPATEN GOWA)
Authors: Febrianty Lilis , Muchlis Saiful 
Published: November 2022

Abstrak, Penelitian ini bertujuan untuk mengetahui perhitungan harga pokok produksi menggunakan metode full costing dan variable costing. Jenis penelitian yang digunakan adalah jenis penelitian kuantitatif. Dengan pendekatan deskriptif Berdasarkan karateristik masalah yang diangkat oleh peneliti, maka penelitian ini diklasifikasikan sebagai penelitian deskriptif kuantitatif. Data yang digunakan dalam penelitian ini yaitu data sekunder yang diperoleh langsung dari pihak perusahaan seperti data laporan keuangan perusahaan terkhusus pada laporan produksi perusahaan selama tahun 2018. Sedangkan untuk data serta data sekunder yang lainnya diperoleh dari buku, jurnal, internet atau media lain yang mendukung penelitian ini. Hasil analisis data menunjukkan bahwa perhitungan harga pokok produksi variable costing lebih rendah dibandingkan dengan perhitungan harga pokok produksi dengan menggunakan metode full costing. Harga pokok produksi yang dihitung menggunakan metode full costing yaitu sebesar Rp 1.475/m3 dan menurut metode variable costing yaitu sebesar Rp1.198/m3. selisi dari keduanya yaitu sebesar Rp. 277/m3. Hal ini disebabkan karena dalam perhitungan biaya overhead pabrik perusahaan tidak memperhitungkan beberapabiaya kedalam harga pokok produksi jika menggunakan variable costing seperti biaya pemeliharaan alat produksi, dan biaya depresiasi pada produk air bersih.
Virtual Assessment in English Language Teaching during COVID-19 Pandemic: Challenges and Considerations in Bangladesh Perspectives
Authors: Haque Md. Nazmul Haque , Md. Mozaffor Hossain  
Published: November 2022

Background:
This study examines the methods of assessing the learners of English Language Teaching (ELT) learners virtually, obstacles both the teachers and students face in virtual assessment, the kind of renovations both teachers and learners have to accommodate for effective virtual assessment, and the imperative suggestions they have in terms of more fruitful and plausible assessment during COVID-19-like pandemics in the context of Bangladesh.
Methodology:
10 teachers and 21 students from 5 renowned private universities in Bangladesh participated in the study. And it applied a mixed-method approach consisting of both qualitative and quantitative research methods.
Findings:
The findings of the study revealed that all the teachers and students go through virtual assessment during the COVID-19 lockdown; the majority of them use Zoom Meeting App and Google Classroom for both summative and formative assessments in the form of mostly virtual viva voce, online assignment, and presentation; virtual assessment is time and money-saving, and has scheduled benefits; its disadvantages include, mainly, unstable internet connection across the country; and most suggest for both teachersâ€™ and studentsâ€™ training in dealing with technological devices and apps used for virtual assessment.
Conclusion:
The major results of the research suggest that virtual assessment in ELT in the Bangladeshi context requires substantial technological modifications and renovations.
Originality:
Since online assessment in ELT, like other academic disciplines, is in function in Bangladesh, better decisions on assessment methodology and, logically, more appropriate assessment policies can be formed. Conforming to this purpose, this research aims to unearth the existing challenges both teachers and learners encounter in virtual assessment and modifications recommended by them.
PENERAPAN METODE HIDROPONIK SEDERHANA DALAM MENGEMBANGKAN BUDIDAYA SAYURAN UNTUK PEMBERDAYAAN MASYARAKAT DESA PERMATA BARU, KABUPATEN OGAN ILIR
Authors: Susilawati Susilawati , Irmawati Irmawati , Ammar Muhammad , Sulaiman Firdaus , Sodikin Erizal , Harun Muhammad Umar 
Published: November 2022

Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk memberdayakan masyarakat Desa Permata Baru agar mampu melakukan budidaya tanaman pada lahan terbatas menggunakan metode hidroponik sederhana untuk dapat memenuhi kebutuhan gizi keluarga. Kegiatan ini dilaksanakan di Desa Permata Baru Kecamatan Inderalaya Utara Kabupaten Ogan Ilir Sumatera Selatan. Metode yang digunakan adalah penyampaian materi hidroponik, media tanam, nutrisi dan tahapan budidaya sayuran hidroponik. Untuk mengetahui kemampuan ibu-ibu dilakukan praktek langsung budidaya sayuran. Luaran dari kegiatan pengabdian ini adalah kelompok masyarakat di Desa Permata Baru mampu melakukakan budidaya sayuran dengan metode hidroponik sederhana secara 1] mandiri, 2] mampu menyediakan sayuran untuk konsumsi rumah tangga sebagai upaya peningkatan gizi keluarga, dan 3] mampu melakukan budidaya tanaman khususnya sayuran dengan metode hidroponik secara kontinyuitas. Hasil dari kegiatan pengabdian ini ibu-ibu kelompok wanita tani Permata Hijau mampu memproduksi sayuran antara lain Pakcoy putih, Selada merah, Selada hijau, Pakcoy hijau, Pakcoy merah, Caisim, Bayam merah dan Sawi pagoda dengan metode hidroponik sederhana
Kata Kunci: Pemberdayaan, budidaya, hidroponik, lahan terbatas
ABSTRACT
The objective of this community service activity was to empower the people of Permata Baru Village to cultivate plants on limited land using a simple hydroponic method in order to meet family nutritional needs. This activity was carried out in Permata Baru Village, North Inderalaya District, Ogan Ilir Regency, South Sumatra. The method used was by giving courses of hydroponic material, planting media, nutrition and stages of hydroponic vegetable cultivation. Direct hydroponic practice for vegetable cultivation was also carried out to sharpen the participants’ skills. The output of this service activity was that community groups in Permata Baru Village could carry out vegetable cultivation using a simple hydroponic method 1] independently, 2] to produce vegetables for household consumption as an effort to improve family nutrition, and 3] to cultivate plants, especially vegetables with continuous hydroponic method. Through this service activity, it was resulted that women farmer groups in Permata Hijau were able to produce vegetables, including white bok choy, red lettuce, green lettuce, green bok choy, red bok choy, choy sum, red spinach and tatsoi using a simple hydroponic method.
Keywords: Empowerment, cultivation, hydroponic, limited land