bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ornamental fighting fish is the next model organism for genetic studies
Authors: Yue Gen Hua , Wang Le , Sun Fei , Yang Zituo , Shen Yubang , Meng Zining , Alfiko Yuzer 
Published: April 2022

AbstractThe fighting fish Betta splendens is a freshwater species from Thailand and other Southeast Asian countries. This fish has been domesticated for 1000 years and bred for fighting, various colours, body size and fin types for 600 years. It is one of the most important fish species cultured for the world ornamental fish market. This fish is easy to culture, highly fecund and displays great morphological diversity. Its biology has been studied for over 100 years. Recently, its compact genome and transcriptomes have been sequenced. Genome editing with CRISPR/cas9 has been applied to knock out genes in this fish. Its diverse phenotypes, including colours, colour patterns, fin types, and aggressive behaviour, are complementary to those of other model animals. Therefore, this fish could be the next important model organism for studying phenotypic variation and aggressive behaviour. In this paper, we synthesized knowledge about its aquaculture, biology, genetics, genomic tools, phenotypes and novel insights on phenotypic variation, sex determination and aggression. We hope that the information described in this paper will facilitate genetic studies on phenotypic variations in aquaculture and aggressive behaviour in other species, including humans.
Convalescent plasma for COVID‐19: Donor demographic factors associated high neutralising antibody titres
Authors: Mehew Jennifer , Johnson Rachel , Roberts David , Griffiths Alex , Harvala Heli 
Published: April 2022

AbstractBackgroundConvalescent plasma containing high levels of SARS‐CoV‐2 antibodies has been studied as a possible treatment for COVID‐19. Better understanding of predictors of high antibody levels is needed for improving supply of high‐quality therapeutic plasma.AimsWe have evaluated demographic and clinical factors associated with the probability of a convalescent plasma donor having high SARS‐CoV‐2 IgG antibody levels.MethodsA total of 29,585 convalescent plasma donors employed during the first and second waves of the COVID‐19 pandemic in England were included in this study. All had been tested for SARS‐CoV‐2 IgG antibodies by EUROimmun ELISA. A multivariable logistic regression model was used to quantify the association of the demographic and clinical factors with high (EUROimmun S/Co>6.0) SARS‐CoV‐2 IgG antibody level.ResultsMost of the donors were male (23,024; 78%), with white ethnic background (24,598;83%) and had not been tested for SARS‐CoV‐2 (15,266; 52%).Overall, less than 20% of convalescent plasma donors with confirmed or suspected SARS‐CoV‐2 infection harboured high SARS‐CoV‐2 antibody levels (n = 4,978). We found that older male donors who had been hospitalised with COVID‐19 were most likely to harbour high levels of antibodies. White donors were less likely to have high SARS‐CoV‐2 antibody levels than donors with Asian orblack ethnic backgrounds residing in affluent areas likely reflecting ethnic inequality previously associated with SARS‐CoV‐2 infection.DiscussionIn a time of great uncertainty, and predicted new waves associated with newly emerging SARS‐CoV‐2 variants, these results will help us to target future convalescent plasma collections.
Mechanics-Guided Design of Wearable Network Heaters for Bio-Integrated Applications
Authors: Zhao Zhao , Yin Yafei , Li Yuhang , Song Jizhou 
Published: April 2022

Abstract
Wearable heaters that can retain conformal contact with human skin have attracted significant attention in recent years due to their enormous potential in thermotherapy. Existing strategies for wearable heaters are constrained by fixed configurations or dimensions, which limit their broad utilities in bio-integrated applications requiring heaters of various sizes. Here, we report a mechanics-guided design of wearable network heaters based on the lattice structure with the negative Poisson’s ratio combined with the uniaxial stretch, which allows for the easy realization of heaters with different sizes and relatively uniform heating performance. Theoretical and computational mechanics studies reveal the fundamental aspects of the design and operation of the network heaters. Thermal analyses of the network heaters integrated with human skin are performed to investigate the influences of design parameters on the skin temperature. This study offers an easy route for wearable network heaters and provides design guidelines for their fabrications.
Stability and Robustness Analysis of Quasi-Periodic System Subjected to Uncertain Parametric Excitations and Nonlinear Perturbations
Authors: Subramanian Susheelkumar C. , Redkar Sangram 
Published: April 2022

Abstract
In this work, the asymptotic stability bounds are identified for a class of linear quasi-periodic dynamical systems with stochastic parametric excitations and nonlinear perturbations. The application of a Lyapunov–Perron (L-P) transformation converts the linear part of such systems to a linear time-invariant form. In the past, using the Infante’s approach for linear time-invariant systems, stability theorem and corollary were derived and demonstrated for time periodic systems with variation in stochastic parameters. In this study, the same approach is extended toward linear quasi-periodic with stochastic parameter variations. Furthermore, the Lyapunov’s direct approach is employed to formulate the stability conditions a for quasi-periodic system with nonlinear perturbations. If the nonlinearities satisfy a bounding condition, sufficient conditions for asymptotic stability can be derived for such systems. The applications of stability theorems are demonstrated with practical examples of commutative and noncommutative quasi-periodic systems.
Two-stage exhumation of deeply subducted continental crust: Insight from zircon, titanite, and apatite petrochronology, Sulu belt of eastern China
Authors: Wang Songjie , Brown Michael , Wang Lu , Johnson Tim E. , Olierook Hugo K.H. , Kirkland Christopher L. , Kylander-Clark Andrew , Evans Noreen J. , McDonald Bradley J. 
Published: April 2022

Abstract
The rates and mechanisms by which deeply subducted continental crust was exhumed back to the surface are not well understood, but can be better characterized using multimineral petrochronology. Here, we combine zircon, titanite, and apatite U-Pb ages from leucogranite and phengite gneiss with a pressure–temperature (P–T) path from eclogite to provide robust quantitative constraints on cooling and exhumation of the Sulu belt, a large ultrahigh-pressure metamorphic terrane in eastern China. The leucogranite, which formed during exhumation, is enriched in light rare earth elements (REE) relative to heavy REE and in large ion lithophile elements relative to high field strength elements, similar to hydrous crustal melts. Whole-rock Sr-Nd isotope compositions indicate that the leucogranite was not directly derived from the host phengite gneiss, but was more likely sourced from deeper in the exhuming crust. For the gneiss, mantles on inherited zircon yield an age of 230 ± 2 Ma and a temperature of 802 ± 36 °C based on a minimum pressure of 2.9 GPa, which records the minimum timing and P–T of initial decompression. Overgrowths on inherited zircon from the leucogranite constrain crystallization to 224 ± 1 Ma, coeval with the growth of zircon rims in the gneiss, at a temperature of 764 ± 42 °C and a pressure within the quartzeclogite facies. Titanite and apatite define single populations with lower concordia intercept ages of 222 ± 3 Ma and 198 ± 7 Ma, at temperatures of 720 ± 30 °C and ∼450 ± 100 °C, respectively, recording the timing of passage through the quartz-eclogite to the amphibolite facies and then the transition to the upper greenschist facies. Although the data yield a nearly constant cooling rate of 10.9−3.6+4.5 °C/m.y., exhumation was completed in two stages. The first stage from coesiteeclogite facies to ∼1.2 GPa, corresponding to the depth of the Moho, occurred at a rate of 7.5−2.6+5.8 km/m.y. Thereafter, exhumation into the mid-crust occurred at a much slower rate of 0.87−0.71+0.86 km/m.y. The first stage of faster exhumation was accompanied by migration of leucogranite melt along foliation in the gneiss, which would have decreased the average density and weakened the crust, enhancing the rate of return flow.
Periodic Approximation of the Rotational Motion of the Photon-12 Satellite
Authors: Bulanov D. M. , Sazonov V. V. 
Published: April 2022

Abstract
The results of repeated processing of magnetic measurements carried out on the Photon-12 satellite (which was in orbit from September 9 to 24, 1999) are described. The processing was performed in order to reconstruct the uncontrolled rotational motion of this satellite. In re-processing, the simplified mathematical model of rotational motion was used. The actual orbit of a satellite (the apogee height is 380 km, the perigee height is 220 km) is replaced by a circular orbit; the expression for the aerodynamic moment acting on a satellite is simplified. The system of differential equations underlying the new model is autonomous and proved to be sufficiently accurate to reconstruct the satellite motion based on magnetic measurements in the case in which the satellite angular velocity was not very low and grew gradually. In the last third of the flight, when the satellite motion became virtually stable and had a sufficiently high angular velocity, this system could be reduced to a generalized-conservative system. Such a reduction makes more definite the set of its solutions suitable for approximate description of the actual motion of a satellite. In some segments of motion, the combining of which covers about 3 days, it was possible to use, for this purpose, the periodic solutions continued from the Lyapunov periodic solutions.
Indicators for implementation outcome monitoring of reporting and learning systems in hospitals: an underestimated need for patient safety
Authors: Kuske Silke , Willmeroth Tabea , Schneider Jörg , Belibasakis Sandra , Roes Martina , Borgmann Sandra Olivia , Cartes Febrero Maria Ines 
Published: April 2022

ObjectiveWe aimed to investigate the perception of the implementation success of reporting and learning systems in German hospitals, the perceived relevance of the implementation outcomes and whether and how these implementation outcomes are monitored. An reporting and learning system is a tool used worldwide for patient safety that identifies and analyses critical events, errors, risks and near misses in healthcare.MethodsA pretested exploratory cross-sectional online survey was conducted with reporting and learning system experts from 51 acute care hospitals. For communicative validation, the results were discussed in person in an expert panel discussion (N=23).ResultsFifty-three per cent (n=27) of the participants (N=51) of the online survey perceived that their reporting and learning system was being comprehensively and successfully implemented. However, no service or patient outcomes were reported to ultimately capture the concept of implementation success. Most of the participants reported a (high) relevance of the implementation outcomes’ acceptability and sustainability. In total, 44 measures were provided to monitor implementation outcomes. However, most of the quantitative measures were based on the (relative) number of entered reports. Qualitative measures were reported in relation to the ‘quality of the report’. In general, the measures were poorly specified.ConclusionThere is an underestimated need to develop validated ‘implementation patient safety indicator(s) (sets)’ to monitor implementation outcomes of reporting and learning systems. We also identified a potential need to facilitate awareness of the concept of implementation success and its relevance for patient safety. Drafts of indicators that could be used as a starting point for the further development of ‘implementation patient safety indicators’ were provided.
Decomposition differences between snags and logs in forests of Kenai Peninsula, Alaska
Authors: Yatskov Mikhail A. , Harmon Mark E. , Fasth Becky , Sexton Jay , Hoyman Toni L. , Dudoit Chana M. 
Published: April 2022

Rising temperatures could increase forest ecosystem disturbance frequency and severity, transferring large amounts of live biomass to coarse woody debris (CWD) pools that emit carbon (C). The type of disturbance-created CWD influences the rate, amount, and duration of this C emission. We studied the effect of a large-scale disturbance on CWD dynamics in spruce-dominated forests of the Kenai Peninsula, Alaska, by determining CWD decomposition rate constants (k) using the chronosequence and decomposition-vectors methods and by modeling the hypothetical CWD dynamics occurring after a bark beetle outbreak versus a windthrow. Chronosequence-based k’s for mass ranged between 0.020 and 0.022 year−1 for logs and between 0.000 and 0.003 year−1 for snags. Decomposition-vectors-based k’s for log mass ranged between 0.022 and 0.045 year−1 among three decomposition phases and between 0.014 and 0.048 year−1 among five decay classes. Our analysis showed that snag-generating disturbances delayed C flux from CWD to the atmosphere, produced a smaller magnitude of C flux, and had the potential to store 10% to 66% more C in the system over time than disturbances generating logs. Thus, landscapes affected by disturbances creating snags (versus logs) may revert faster to C neutrality, suggesting forest management practices should reflect these differences.
Associated Fuzzy Probabilities in MADM with Interacting Attributes: Application in Multi-Objective Facility Location Selection Problem
Authors: Kacprzyk Janusz , Sirbiladze Gia , Tsulaia Gvantsa 
Published: April 2022

For decreasing service centers’ selection risks in emergency facility location selection, it is crucial to have selected candidate service centers within deeply detailed facility location selection model. To achieve this, a new approach developed in this article involves two stages. In the first stage, the fuzzy multi-attribute group decision making (MAGDM) model for evaluation of the selection of candidate service centers is created. For the aggregation of experts’ assessments of candidate service centers (with respect to attributes) aggregation operators’ approach is used. Experts’ assessments are presented in fuzzy terms with semantic form of triangular fuzzy numbers. For the deeply detailed facility location selection modeling and for the intellectual activity of experts in their evaluations, pairwise interactions between attributes of MAGDM model are considered in the construction of the second-order additive triangular fuzzy valued fuzzy measure (TFVFM). The associated triangular fuzzy probability averaging (As-TFPA) aggregation operators’ family is constructed with respect to TFVFM. Analytical properties of the As-TFPA operators are studied. The new operators are certain extensions of the well-known Choquet integral operator. The extensions, in contrast to the Choquet aggregation, consider all possible pair-wise interactions of the attributes by introducing associated fuzzy probabilities of a TFVFM. At the end of the first stage, a candidate service center’s selection index is defined as As-TFPA operator’s aggregation value on experts’ assessments with respect to attributes. At the second stage, fuzzy multi-objective facility location set covering problem (MOFLSCP) is created for facility location selection optimal planning with new criteria: (1) maximization of candidate service centers selection index and classical two criteria, (2) minimization of the total cost needed to open service centers and (3) minimization of number of agents needed to operate the opened service centers. For the constructed two-stage methodology a simulation example of emergency service facility location planning for a city is considered. The example gives the Pareto fronts obtained by As-TFPA operators, the Choquet integral-TFCA operator and well-known TOPSIS approach, for optimal selecting candidate sites for the servicing of demand points. The comparative analysis identifies that the differences in the Pareto solutions, obtained by using As-TFPA operators and TFCA operator or TOPSIS aggregation, are also caused by the fact that TFCA operator or TOPSIS approach considers the pair interaction indexes for only one consonant structure of attributes. While new As-TFPA aggregations provide all pairwise interactions for all consonant structures.
Application of green-emitting Sr<sub>3</sub>WO<sub>6</sub>:U phosphor to enhance lumen efficiency of WLEDs
Authors: Dang Huu Phuc , That Phung Ton 
Published: April 2022

The article demonstrates a sample of spectrum in the phosphor-covered WLED (abbreviated as p-WLED) containing one blue chip, one red chip along with phosphors of green and yellow colors. We acquired the p-WLEDs’ ideal spectrum in the CCTs, which is short for correlated color temperature range from 2700 K to 6500 K using a nonlinear program in order to optimize the radiation’s lumen efficiency (LER) when the R9 strong red's color rendering indexes (CRIs) and special CRIs exceed 98. From the outcomes of the recreation, p-WLEDs containing an InGaN blue chip with 450 nm wavelength, an AlGaInP red chip with 634 nm wavelength, along with green and yellow silicate phosphors with the value of 507 and 580 nm wavelength correspondingly; can produce white lights with CRI values of around 98 and particular CRI values of R9 for intense reds above 98. For saturated red, yellow, green, and blue colors, the average values of the particular CRIs R9 through R12 exceed 95. In CCT values of 2700 K to 6500 K, the R13 value in female figures is around 100, with LER values reaching 296 lm/W.
O papel da gestão por algoritmos como suporte para os sistemas de controle gerencial na economia compartilhada: um estudo sobre a percepção dos motoristas de empresas do transporte por aplicativo no contexto brasileiro
Authors: Avelar Ewerton Alex , Jordão Ricardo Vinícius Dias , Ferreira Gabriela Maria Couto , Silva Beatriz Najela Ekaterina Ribeiro da 
Published: April 2022

O objetivo desta pesquisa foi descrever o papel da gestão por algoritmos como suporte do sistema de controle gerencial (SCG) das empresas 99 Tecnologia Ltda. (99TL) e UBER, considerando os modelos de Malmi e Brown (2008) e Jordão et al. (2013). Procedeu-se a um estudo qualitativo, descritivo e documental. Com base na análise dos dados e informações obtidos a partir de relatos em vídeos de motoristas e documentos públicos das empresas, percebeu-se que que ambas as organizações utilizaram as ferramentas dos tipos de SCG descritos por Jordão et al. (2013) e Malmi e Brown (2008). Ademais, foi possível constatar que: (i) os motoristas se ajustaram ao SCG dessas empresas; (ii) houve uma forte inter-relação entre as ferramentas dos diferentes tipos de controle; e (iii) que o uso de algoritmos foi importante ao exercício prático do controle nas empresas da economia compartilhada estudadas.
Análise em 4-D: uma reflexão sobre a “autocracia burguesa” no Brasil
Authors: Belinelli Leonardo Octavio 
Published: April 2022

O artigo discute o conceito de “autocracia burguesa” tal como elaborado por Florestan Fernandes. Tomando como referência principal A revolução burguesa no Brasil (1975), procura-se examiná-lo teórica e historicamente, como também levantar algumas hipóteses explicativas a respeito de seu abandono no debate intelectual brasileiro a partir dos anos 1990. Ademais, sugere-se como alguns de seus supostos podem colaborar para o exame da situação política contemporânea do país.
A dimensão normativa da política: entrevista com Álvaro de Vita
Authors: Sendretti Lilian , Rosa Gabriela , Freller Felipe 
Published: April 2022

Álvaro de Vita é professor titular do Departamento de Ciência Política da USP, atuando nas áreas de teoria política contemporânea, especialmente teorias da justiça, teorias da democracia, tolerância e justiça internacional. Foi editor da Revista Lua Nova (1991-1999). É autor dos livros Justiça liberal: Argumentos liberais contra o neoliberalismo (Paz e Terra, 1993), A justiça igualitária e seus críticos (WWF Martins Fontes, 2007) e O liberalismo igualitário: sociedade democrática e justiça internacional (WWF Martins Fontes, 2008). Nesta entrevista, realizada por e-mail em 2021, o professor Álvaro nos contou sobre sua trajetória acadêmica na teoria política, sobre as diferenças intergeracionais no campo desde a sua formação, sobre a importância da teoria política para reflexão de questões públicas fundamentais e sobre os desafios da democracia brasileira.
Compounding Benefits of Cholesterol-Lowering Therapy for the Reduction of Major Cardiovascular Events: Systematic Review and Meta-Analysis
Authors: Wang Nelson , Woodward Mark , Huffman Mark D. , Rodgers Anthony 
Published: April 2022

Background:
Mendelian randomization studies use genetic variants as natural experiments to provide evidence about causal relations between modifiable risk factors and disease. Recent Mendelian randomization studies suggest each mmol/L reduction in low-density lipoprotein cholesterol (LDL-C) sustained over a lifetime can reduce the risk of cardiovascular disease by more than half. However, these findings have not been replicated in randomized clinical trials, and the effect of treatment duration on the magnitude of risk reduction remains uncertain. The aim of this article was to evaluate the relationship between lipid-lowering drug exposure time and relative risk reduction of major cardiovascular events in randomized clinical trials.

Methods:
We conducted a systematic review and meta-analysis of randomized clinical trials of statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors that report LDL-C levels and effect sizes for each year of follow-up. The primary end point was major vascular events, defined as the composite of cardiovascular death, myocardial infarction, stroke, and coronary revascularization. Hazard ratios during each year of follow-up were meta-analyzed using random-effects models.

Results:

A total of 21 trials with 184 012 patients and an average mean follow-up of 4.4 years were included. Meta-regression showed there was greater relative risk reduction in major vascular events with increasing duration of treatment (
P
<0.001). For example, each mmol/L LDL-C lowered was associated with a relative risk reduction in major vascular events of 12% (95% CI, 8%–16%) for year 1, 20% (95% CI, 16%–24%) for year 3, 23% (95% CI, 18%–27%) for year 5, and 29% (95% CI, 14%–42%) for year 7.

Conclusions:
The benefits of LDL-C lowering do not seem to be fixed but increase steadily with longer durations of treatment. The results from short-term randomized trials are compatible with the very strong associations between LDL-C and cardiovascular events seen in Mendelian randomization studies.