bluuebunny/crossref_metadata_2025_split huggingface dataset:
Processo de Pedido e Projeto de Pedido de Indicações Geográficas. Menos Burocracia e mais Estratégia
Authors: Aveni Alessandro 
Published: March 2022

O trabalho faz parte da pesquisa pós-doutoral do autor e desenvolve uma definição do processo que uma organização local deve executar para apoiar o pedido de criação da IG. Ao contrário da literatura encontrada a criação de uma IG não é somente um processo burocrático ligado a propriedade intelectual como é colocado na literatura. O resultado do trabalho aponta ao fato que para desenvolver o pedido de uma IG deve existir uma estratégia e network locais para apoiar o processo. O resultado serve para definir os processos de intervenção de um NIT de base universitária que quer apoiar a criação de IG no território.
Prospecção Tecnológica, Propriedade Intelectual e Inovação
Authors: Coutinho Shirley Virgínia 
Published: March 2022

A prospecção tecnológica é o primeiro passo na longa jornada da estratégia de agregação de valor a novos conhecimentos e a novas tecnologias, por meio da proteção jurídica da propriedade intelectual, visando a sua conversão em inovação. Isso porque é por meio da prospecção em bases de dados de propriedade intelectual que se consegue verificar se o objeto inovador atende ao requisito novidade, fundamental para a proteção, sobretudo por meio de patente de invenção. Esta tem por objetivo darà inovação baseada no objeto da proteção ou que o contenha a necessária segurança jurídica, de modo que o empreendedor, que aceita assumir o risco de investir para introduzir essa novidade no mercado, obtenha a vantagem de sua exclusividade por um tempo determinado.Sabe-se que o longo caminho a ser percorrido pela materialização de uma ideia inovadora, para ser convertida em inovação, começa com sua revelação, seguida de sua prospecção, que precisar ter preenchidos os requisitos indispensáveis à proteção da propriedade intelectual, e desta receber valor transacional, como um bem intangívela ser objeto de investimento de capital financeiro e tecnológico, a fim de chegar ao mercado produzindo riqueza e bem-estar, seja por meio do aumento da produtividade e da competitividade, seja do aumento da qualidade de vida, em síntese, em benefício da sociedade.Há, portanto, uma lógica a ser seguida na implementação de uma estratégica destinada a incrementar a inovação que compreende diversos atores em interação e cuja colaboração é fundamental para o alcance desse objetivo, porque a pesquisa de qualidade e a criatividade nem sempre pertencem ao mesmo grupo que empreende e leva a novidade ao mercado. Por essa razão, a comunicação e a colaboração desses atores são fundamentais para o sucesso do empreendimento, que inclui múltiplas permutas, indispensável apoio financeiro e incentivos de diversas naturezas.Como dizia Peter Drucker, a maioria das inovações resulta da busca consciente e intencional de oportunidades, e a prospecção tecnológica é fundamental não só para verificar o estado da técnica mas também para indicar territórios onde o objeto da pesquisa está sendo encontrado, permitindo o mapeamento de eventuais parceiros ou concorrentes, bem como caminhos alternativos que possam garantir a exclusividade necessária à introdução de uma inovação no mercado
Differences in cardiovascular risk levels between cleaning staff and hotel housekeepers
Authors: López-González Ángel Arturo , Manzanero Zoe , González San Miguel Hilda María , Arroyo Bote Sebastiana , Riutord Sbert Pere , Rigo Vives María del Mar , Ramírez Manent José Ignacio 
Published: March 2022

Abstract

Background and objective
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, with a greater incidence in the most disadvantaged social classes. In this study, we aimed to evaluate the level of cardiovascular risk in cleaning workers.

Methods
This was a descriptive, cross-sectional study in 46.632 cleaning workers (40.169 women and 6.463 men). Thirty-one different scales related to cardiovascular risk were studied (14 assessing overweight and obesity, 5 determining the risk of nonalcoholic fatty liver disease, 5 scales of cardiovascular risk, 4 atherogenic indices, and 3 scales of metabolic syndrome, among others). The results obtained were divided between personnel who perform their cleaning tasks in the hotel and catering industry and those in other sectors.

Results
The prevalence of obesity and arterial hypertension in cleaning workers was over 20% in both sexes. A similar amount was observed in moderate or high values on the REGICOR (Registre GIroní del COR) scale. More than 15% presented metabolic syndrome according to the NCEP ATPIII (National Cholesterol Education Program-Adult Treatment Program III) criteria, while over 10% of women and 20% of men had a high risk of nonalcoholic fatty liver disease assessed with the fatty liver index.

Conclusion
Cardiovascular risk is higher, in both sexes, in the group of cleaning workers who work in companies other than hotels.
Marginal Odds Ratio Estimators
Authors: Drake Christiana 
Published: March 2022

Abstract
The odds ratio is a common measure to assess the association between a binary predictor variable and a binary outcome. In epidemiology, the outcome is often the disease status, and the predictor of interest is a suspected risk factor for the disease. The purpose of the study is an attempt to establish a causal association between exposure and disease. If the object of a study is the estimation of a marginal odds ratio, defined as the ratio of the odds that would be observed in a population if everyone were exposed versus the odds in the same population if no one were exposed, methods such as the Mantel–Haenszel estimator are commonly used. When it is necessary to adjust for many confounders and/or continuous confounders, this approach results in a biased and inconsistent estimator, including matching and stratification by the propensity score. An alternative to matching is inverse probability weighting by the propensity score. The resulting estimator is consistent, provided the propensity score model is correct and adjusts for all confounders.
Presence and Implications of Anti‐Angiotensin Converting Enzyme‐2 Immunoglobulin M Antibodies in Anti‐Melanoma‐Differentiation‐Associated 5 Dermatomyositis
Authors: Mecoli Christopher A. , Yoshida Akira , Paik Julie J. , Lin Cheng Ting , Danoff Sonye , Hanaoka Hironari , Rosen Antony , Christopher‐Stine Lisa , Kuwana Masataka , Casciola‐Rosen Livia 
Published: March 2022

ObjectivePatients with anti‐melanoma‐differentiation‐associated 5 (anti‐MDA5)‐positive dermatomyositis (DM) share several striking similarities to patients with SARS‐CoV‐2. Our objective was to assess the prevalence of anti‐angiotensin converting enzyme‐2 (ACE2) immunoglobulin M (IgM) antibodies, found in patients with severe SARS‐CoV‐2, in two independent anti‐MDA5‐positive DM cohorts.MethodsAnti‐ACE2 IgM antibodies were assayed by enzyme‐linked immunosorbent assay (ELISA) in two anti‐MDA5‐positive DM cohorts: a predominantly outpatient North American cohort (n = 52) and a Japanese cohort enriched for new‐onset disease (n = 32). Additionally, 118 patients with SARS‐CoV‐2 with a spectrum of clinical severity were tested for anti‐MDA5 antibodies by ELISA.ResultsFive of fifty‐two (9.6%) North American patients and five of thirty‐two (15%) Japanese patients were positive for anti‐ACE2 IgM. In the North American cohort, all five patients with anti‐ACE2 IgM antibodies had proximal muscle weakness, had interstitial lung disease, were significantly more likely to receive pulse dose methylprednisolone (80% vs 30%, P = 0.043), and had worse forced vital capacity (median 59% predicted vs 78%, P = 0.056) compared with the anti‐ACE2‐IgM‐negative group. In the Japanese cohort, all five anti‐ACE2‐IgM‐positive patients also required pulse dose methylprednisolone, and three of five (60%) patients died. Japanese patients with anti‐ACE2 IgM had significantly worse oxygenation, as defined by a lower partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (233 vs 390, P = 0.021), and a higher alveolar‐arterial oxygenation gradient (91 vs 23 mm Hg, P = 0.024) than the IgM‐negative group.ConclusionWe describe anti‐ACE2 IgM autoantibodies in two independent cohorts with anti‐MDA5‐positive DM. These autoantibodies may be biomarkers for severe disease and provide insight into disease pathogenesis.
Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications
Authors: Hao Xin , Du Ting , He Huatao , Yang Feng , Wang Yilan , Liu Gang , Wang Yaolei 
Published: March 2022

AbstractFunctional microfluidic particle reactors (MPRs), prepared with microfluidic emulsions with biomaterials as the templates, can directly encapsulate bioactive substances to achieve different biomedical applications. Different types of MPRs (such as single structure MPRs, mixed structure MPRs, and all‐aqueous structure MPRs) have multifarious functions owing to the prominent interface characteristics endowed by emulsion templates with exquisite controlled fluid components and interface structures, as well as functional biomaterials with attractive properties. Notably, the constructed MPRs are endowed with better controllability, biocompatibility, and injectability with the significant advances in the burgeoning droplet microfluidic technology and material science. This contributes to the improvement of the flexibility and degree of freedom of the MPRs supporting cell and drug‐related biomedical applications (such as 3D cell culture, cell/drug delivery, and controlled drug release), leading to more effective diagnosis and treatment. In this paper, the correlation between the particle structure, determined by optimizing emulsion template fluid components and interfacial complexity, and the interface characteristics of the MPRs are primarily investigated. Next, the interface characteristics of the MPRs expanded by functional biomaterials are reviewed, as well as the distinct properties of MPRs in the biomedical applications related to cells and drugs. Finally, the existing challenges and future perspectives are discussed to improve the unique interface characteristics of MPRs in broader biomedical applications.
Photon Walk in Transparent Wood: Scattering and Absorption in Hierarchically Structured Materials
Authors: Chen Hui , Montanari Céline , Shanker Ravi , Marcinkevicius Saulius , Berglund Lars A. , Sychugov Ilya 
Published: March 2022

AbstractThe optical response of hierarchical materials is convoluted, which hinders their direct study and property control. Transparent wood (TW) is an emerging biocomposite in this category, which adds optical function to the structural properties of wood. Nano‐ and microscale inhomogeneities in composition, structure, and at interfaces strongly affect light transmission and haze. While interface manipulation can tailor TW properties, the realization of optically clear wood requires detailed understanding of light–TW interaction mechanisms. Herein is shown how material scattering and absorption coefficients can be extracted from a combination of experimental spectroscopic measurements and a photon diffusion model. Contributions from different length scales can thus be deciphered and quantified. It is shown that forward scattering dominates haze in TW, primarily caused by refractive index (RI) mismatch between the wood substrate and the polymer phase. Rayleigh scattering from the wood cell wall and absorption from residual lignin have minor effects on transmittance, but the former affects haze. Results provide guidance for material design of transparent hierarchical composites toward desired optical functionality; it is demonstrated experimentally how transmittance and haze of TW can be controlled over a broad range.
Atypical tooth wear found in fossil hominins also present in a Japanese macaque population
Authors: Towle Ian , MacIntosh Andrew J. J. , Hirata Kazuha , Kubo Mugino O. , Loch Carolina 
Published: March 2022

AbstractObjectivesAtypical tooth wear, including macroscopically visible striations on anterior teeth and within root grooves on posterior teeth, are often regarded as evidence of non‐masticatory, tool use behavior in fossil hominins. Both these types of dental tissue loss are often considered unique to the genus Homo and suggested to be the earliest evidence of human cultural habits. The aim of this study was to describe similar tooth wear found in a wild primate population and to conduct a differential diagnosis of this atypical tissue loss.Materials and MethodsThe focus of this study was a sample of wild Japanese macaques from Koshima Island, Japan. Individuals were provisioned regularly on the beach as part of one of the longest running primate field sites. Tooth wear and fractures in this group were compared to two other non‐provisioned populations. Information on diet and behavior were obtained from extensive literature and on‐going field observations.ResultsAll Koshima Island individuals analyzed showed atypical tooth wear. Large macroscopic striations were visible on many teeth, with sub‐vertical striations prominent on the labial surfaces of incisors. Root grooves on posterior teeth were observed in half of the individuals, some showing clear directional striations similar to those reported in “toothpick” grooves in fossil hominins. Tool use and the habitual insertion of non‐masticatory items in the mouth has not been observed in this population.DiscussionAccidental ingestion of sand and oral processing of marine mollusks likely creates these atypical wear patterns. Implications for similar wear that has been associated with tool‐use in fossil hominin samples were discussed.
RETRACTED: Evaluation of psychometric characteristics of light triad personality questionnaire in nurses
Authors: Farah Bijari Azam , Hefazi Torghabeh Leila , Dehshiri Gholamreza 
Published: March 2022

AbstractIntroductionPersonality is one of the important etiological factors of psychological factors. In this regard, one of the important factors in the success of people's social and psychological life is the light triad personality. They are a combination of sympathy, compassion, and humanity. On the basis of results of the research, it is not possible to trust the psychometrics characteristics of tools; it is necessary to evaluate the psychometric characteristics of these tools. Meanwhile, the aim of the present study is the evaluation of psychometrics characteristics of light triad personality in nurses.MethodsThe statistical population includes all nurses who were employed in the summer and autumn of 2020 in private centers and hospitals affiliated with Mashhad University of Medical Sciences. The sample of this study was 245 nurses who were selected by convenience sampling. To analyze the data, exploratory and confirmatory factor analysis, Pearson correlation, total question‐score correlation, and reliability analysis were used by using SPSSV22 and LISRELV8.80 software.ResultsThe results of exploratory and confirmatory factor analysis confirmed the three‐factor structure of the light triad personality questionnaire. The findings of the convergent validity of the light triad personality questionnaire were evaluated and confirmed via its simultaneous implementation by the Social Health and Emotional Sympathy Questionnaires and its divergent reliability was confirmed by the Machiavellian Questionnaire. The reliability coefficient of the questionnaire was obtained for the factors of sympathy, compassion, philanthropy, and totality by using Cronbach's alpha coefficient, 0.83, 0.75, 0.70, and 0.92, respectively.ConclusionFinally, with regard to the desired validity and reliability coefficients, ease of implementation, scoring, interpretation, and explanation, as well as a short time to answer, it can be said that light triad personality questionnaires were qualified for use in psychological research to measure the rate of light triad personality.
Organizational change in response to environmental complexity: Insights from the business model innovation literature
Authors: Martinez Fabien 
Published: March 2022

AbstractOrganizational change research to date has tended to proliferate on a conceptualization of change as a deliberate process driven by rational and formal strategic planning and fuelled by the expansion of exploitative resources. This conceptualization entails that change is essentially a process of reproduction in that it occurs along existing (incremental and cumulative) trajectories. Prompted by the need to manage increasingly complex and uncertain environments and foster progress towards sustainable development, the question of what are the exploratory forces that stimulate the capacity of business organizations to engage in discontinuous shifts towards new (flexible and creative) trajectories, without excessively disrupting existing ones, has comparatively been neglected. This paper contributes to address gaps in existing research by exploring how organizational change in response to complexity is framed in the literature on business model innovation. Three core categories of constraints to change are identified: relational flaws, functional flaws and the lack of moral motives; and three interacting forces that can be harnessed to overcome these constraints are suggested: sociability, agility and moral inclusivity. The resulting framework has broad implications for organizational change theory, practice, policy and research.
Prediction of tannin, protein, and total phenolic content of grain sorghum using image analysis and machine learning
Authors: Nazari Leyla , Khazaei Azim , Ropelewska Ewa 
Published: March 2022

AbstractBackground and ObjectivesSorghum is an alternative crop where poor soil is a limiting factor for the production of corn. Laboratory measurements of chemical compounds of grains are expensive, time‐consuming predominantly done on powdered samples. Therefore, a rapid and reliable method integrating image processing and machine learning was evaluated for the prediction of total phenolic compounds (TPCs), tannin, and protein.FindingsThe highest TPC (0.83%) was obtained for genotype KGS36 (the brown pericarp) followed by KGS23 (0.54%). The concentration of tannin ranged from 0.008% to 0.616%. Mean comparison revealed variation for the protein concentration (15.17%–11.53%); the highest content obtained by KGS25 and the lowest by KGS36 (p < .01). Multilayer perceptron (MLP) as one of the common artificial neural networks (ANNs) applied to simulate the chemical of the grains was evaluated through the textural features extracted from grain images. For the MLP network, the minimum number of hidden networks was set to 8 and the maximum number was set to 25. For learning and saving, the number of networks was set to 20 and the number of saved networks was set to 5. The best MLP models were selected based on performance (R) and error values for the train, test, and validation sets.ConclusionsAn ANN for the prediction of the chemical concentration was suggested. The correlations between predicted and observed data were higher than .915.Significance and NoveltyThese models are of great significance for the prediction of chemical concentrations of grain sorghum in plant breeding and food industry.
Epididymal leiomyosarcoma: Report of a rare case
Authors: Dehghani Mansoureh , Ariamanesh Mona , Khakbaz Ali 
Published: March 2022

AbstractEpididymal leiomyosarcoma (LMS) is a rare malignancy. Because the risk of recurrence is high, proper approach is important. Here, we present a patient with scrotal swelling who underwent surgical excision via scrotal incision, and the histopathological diagnosis was epididymal LMS. The decision was then made to perform inguinal radical orchiectomy.
Familial essential thrombocythemia: 6 cases from a mono‐institutional series
Authors: Accurso Vincenzo , Santoro Marco , Mancuso Salvatrice , Vajana Giorgia , Tomasello Riccardo , Rotolo Cristina , Camarda Giulia , Mattana Marta , Siragusa Sergio 
Published: March 2022

AbstractRarely essential thrombocythemia (ET) is diagnosed in more than one person within a family. Familial myeloproliferative neoplasms are underdiagnosed. In this report, we describe 6 couples of familial ET, evaluating the heterogeneity of the mutational state and the clinical presentation.
Direct Conversion Syngas to Isobutanol over Ce/ZC Catalysts: Effect of Ce Promoter on the Catalytic Performance
Authors: Wang Liyan , Zhang Tao , Yang Jiaqian , Gong Nana , Ma Qingxiang , Wu Yingquan , Tan Yisheng 
Published: March 2022

AbstractThe fuel‐efficient production of isobutanol via CO hydrogenation is a meaningful path, but still remains large challenges. Here, varied contents Ce promoter were introduced to optimize the catalytic performance of ZnCr‐based catalysts. The evaluation results displayed that 2.5‐Ce/ZC catalyst obtained optimum total alcohols yield and isobutanol selectivity. A combination of XPS, TPD, and in‐situ FTIR measurements was performed to probe into the enhancing effect of Ce promoter. The XPS characterization results disclosed the evident changes in the oxygen vacancy concentration and electron structure derived from Ce doping. Furthermore, this unique structure promoted the formation of HCOO species, and modulated the HCOO binding with proper strength to enable further carbon chain growth. According to the acid‐base properties tests, the doping of Ce introduced meaningful medium strong acid and base sites. The facilitated C−C coupling activity was a forthright result that led to the production of C2+ products, especially isobutanol.
Performance and Mechanism of Gas‐Solid Adsorption in a Rotating Adsorption Bed
Authors: Guo Qiang , Zhao Yue , Qi Guisheng , Liu Youzhi 
Published: March 2022

AbstractA rotating adsorption bed for adsorbing toluene by activated carbon was constructed. It was found that the adsorption capacity of the rotating bed was stronger than that of the fixed bed and showed a faster adsorption rate. The particle diffusion model showed that the adsorption process in a rotating adsorption bed was a combination of surface diffusion and particle diffusion. In the rotating adsorption bed, the contribution rate of intraparticle diffusion to the whole adsorption was the largest, and the adsorption rate of each stage of the rotary adsorption bed was higher than that of the fixed bed. The good external diffusion force of the rotating adsorption bed effectively realized the deep‐pore adsorption of the adsorbent and improved the utilization rate of the adsorbent.
Catalytic Oxidation of Veratryl Alcohol Derivatives Using RuCo/rGO Composites
Authors: Yu Daobo , Lei Puyi , Li Yanfang , Shen Wenzhuo , Zhong Min , Zhang Jiali , Guo Shouwu 
Published: March 2022

AbstractChemoselectively oxidizing Cα−OH to C=O has been considered as a key step for the oxidative depolymerization of lignin. In this work, we design and prepare a series of composites of RuCo alloy nanoparticles and reduced graphene oxide (RuCo/rGO) with different Ru to Co ratios and explore their catalytic activities in the oxidation of veratryl alcohol derivatives, which usually serve as the model compounds for studying lignin oxidation. It is illustrated that the Ru to Co ratio determines the morphology and average size of the RuCo alloy nanoparticles on rGO, and the overall catalytic activities of the composites. The RuCo alloy nanoparticles on rGO with Ru to Co ratios of 1 : 0 to 1.2 : 1 show a unique flower‐shaped morphology that increases the exposure of the active sites and thus promotes their contact with the substrates. The RuCo/rGO composites exhibit high catalytic activities for the oxidation of Cα−OH to aldehydes at 100 °C for 2 h. Additionally, the Co component affords the RuCo/rGO composites with magnetic properties that make the separation and recovery of the catalyst simple. Given the high catalytic performances and easy recovery, the RuCo/rGO composites would be potentially useful for the depolymerization of lignin.