bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Care Education Program among Type II DM Patients
Authors: Syikir Muhammad , Irwan Andi Masyitha , Anisa firdaus Fidya 
Published: June 2022

Introduction: The prevalence of Type 2 Diabetes Mellitus was substantially increased around the world, resulting complications and death.
Objective: The self-care education program aimed patients to prevent complications and to increase their quality of life is needed.
Method: The method used with the help of an electronic data base from journals that have been published through PubMed, Wiley, and Google Scholar as many as 7 articles from 646 articles reviewed.
Results: Description of Diabetes Mellitus self-care education program implementation on body biochemical improvement, life quality improvement from physiological, psychological, knowledge, and attitude side.
Conclusion: self-care education program that consisted of providing health education to patients and families with a variety of learning methods, training and discussion where patients and families are involved in activities, both in exploring the patient's feelings to goal setting and intervention. Implementation of this self-care education program can be applied to health services with the adjustment of media based on the local conditions.
Cold Compress Therapy Against Muscle Stiffness in Patients with Hypokalemia
Authors: Srinayanti Yanti , Abdul Malik Andika , Diaz Lutfi Sandi Yudisa 
Published: June 2022

Introduction: Progressive muscle stiffness, especially in the proximal muscle groups of the lower limbs, in patients with hypokalemia paralysis causes recurrent acute attacks.
Objective: The purpose of this study was to describe the results of applying cold compress therapy as an effort to reduce muscle stiffness in hypokalemia paralysis patients.
Method: This research used the design of the Evidence Based Nursing implementation process consisting of: (1) compiling questions (Problem/population, Intervention, Comparison and Outcome) to be implemented, (2) tracing evidence related to cases to be discussed, (3) assessing the evidence presented. obtained in stage two, and (5) evaluation of the implementation of Evidence Based Nursing.
Result: Giving cold compress therapy intervention, the visual analog scale decreased from level 7 (very severe scale) or scale 1 (mild pain), the patient said that significant decrease in pain scale after cold compress therapy.
Conclusion: Cold compress therapy for 15 minutes can reduce the scale of pain and muscle stiffness.
Comparison of Human Papillomavirus RNA In Situ Hybridization and p16 Immunostaining in Diagnostically Challenging High-Grade Squamous Intraepithelial Lesions in the Background of Atrophy
Authors: Banet Natalie , Mao Quanfu , Chu Sharon , Ruhul Quddus M. 
Published: June 2022

Context.—Human papillomavirus (HPV) in the postmenopausal age group is complex, with infected patients in this age group at increased risk of progressing to invasive disease and showing decreased clearance of the virus. Additionally, atrophic changes of the cervix can make histologic distinction of high-grade squamous intraepithelial lesions (HSILs) difficult.Objective.—To determine morphologic and ancillary testing characteristics of atrophy and HSIL in postmenopausal patients.Design.—Files of patients at least 65 years of age were examined, with 81 patients (109 cases [53 benign, 56 HSIL]) included in the study. Results of morphology, immunostaining (p16 and Ki-67), and HPV RNA in situ hybridization (ISH) were noted on all cases with available material.Results.—Atrophy was present in 96 of 109 cases (88%) overall. Coarse nuclear chromatin was noted in none of the benign cases, in 19 of 30 HSIL biopsies (63%), and in 24 of 26 HSIL excisions (92%). All benign cases were negative for p16 and ISH. In the HSIL cases, 45 of 53 (89%) were positive for p16, and of cases with sufficient tissue for ISH, 44 of 45 (98%) were positive. Of the ISH/p16 discordant cases (n = 7), most were p16 negative/ISH positive (6 of 7; 86%), whereas 1 of 7 (14%) was p16 positive and ISH negative. A majority of HSIL cases showed near–full-thickness elevation of Ki-67 (45 of 54; 83%), whereas mitotic figures were less elevated.Conclusions.—In postmenopausal patients with HSIL, mitotic activity is not reliably elevated, but Ki-67 is consistently high. ISH is a more direct method of HPV detection and should be considered in cases where morphology and immunolabeling show discordance.
Short Training Significantly Improves Ganglion Cell Detection Using an Algorithm-Assisted Approach
Authors: Greenberg Ariel , Samueli Benzion , Fahoum Ibrahim , Farkash Shai , Greenberg Orli , Zemser-Werner Valentina , Sabo Edmond , Hagege Rami R. , Hershkovitz Dov 
Published: June 2022

Context.—
Medical education in pathology relies on the accumulation of experience gained through inspection of numerous samples from each entity. Acquiring sufficient teaching material for rare diseases, such as Hirschsprung disease (HSCR), may be difficult, especially in smaller institutes. The current study makes use of a previously developed decision support system using a decision support algorithm meant to aid pathologists in the diagnosis of HSCR.

Objective.—
To assess the effect of a short training session on algorithm-assisted HSCR diagnosis.

Design.—
Five pathologists reviewed a data set of 568 image sets (1704 images in total) selected from 50 cases by the decision support algorithm and were tasked with scoring the images for the presence or absence of ganglion cells. The task was repeated a total of 3 times. Each pathologist had to complete a short educational presentation between the second and third iterations.

Results.—
The training resulted in a significantly increased rate of correct diagnoses (true positive/negative) and a decreased need for referrals for expert consultation. No statistically significant changes in the rate of false positives/negatives were detected.

Conclusions.—
A very short (&lt;10 minutes) training session can greatly improve the pathologist's performance in the algorithm-assisted diagnosis of HSCR. The same approach may be feasible in training for the diagnosis of other rare diseases.
Vínculos entre pintores y miniaturistas del Gótico Internacional en Valencia. El caso del El Libro de horas Egerton de la British Library de Londres y los Capítulos de la Cofradía de Nuestra Señora de Belén de la Biblioteca de Catalunya.
Authors: Ramón Marqués Nuria 
Published: June 2022

El presente estudio pretende dar a conocer los vínculos con respecto a transferencia de conocimientos entre los miniaturistas y los pintores de retablos valencianos del Gótico Internacional a partir del uso de los mismo modelos estilísticos e iconográficos. Para ello, se analizarán detalladamente las miniaturas de dos manuscritos de origen valenciano como son el Libro de horas Egerton (ms. Egerton 2653), de la British Library de Londres, y el libro Capítulos de la Cofradía de Nuestra Señora de Belén, (ms. 74) de la Biblioteca de Catalunya. Del análisis de estas miniaturas se ha corroborado la fuerte vinculación estilística existente entre ellos con la pintura valenciana, pero a la vez de su estudio se observan ciertos aspectos que nos inducen a pensar en la posibilidad de que algunas de las miniaturas de ambos códices formaran parte de uno mismo, desmembrado en siglos posteriores para decorar los actuales.
Paul Natorp y las condiciones transcendentales de la formación. Sobre la agencia epistémica como problema de la filosofía transcendental
Authors: Trujillo Nicolas Alejandro 
Published: June 2022

En este artículo sostengo que la Pedagogía social de Paul Natorp contiene una epistemología de la agencia epistémica, en tanto describe condiciones praxiológicas necesarias para la producción de conocimiento objetivo. Desarrollaré esta interpretación en tres partes. Primero, con el fin de contextualizar la investigación filosófico-pedagógica de Natorp, explico el contexto universitario, el programa de investigación de la Escuela de Marburg tal como lo desarrolló Natorp. Segundo, analizo el concepto de formación y la historia evolutiva que propone Natorp. Por último, concluyo que una interpretación epistemológica del proyecto pedagógico-social proporciona elementos conceptuales para una comprensión sistemática de la agencia epistémica de sujetos concretos.
Efficacy Analysis of Corneal Photo-vitrification (CPV) for Improved Vision of Age-related Macular Degeneration (AMD) Eyes
Authors: Lin Jui-Teng , Berry Michael 
Published: June 2022

Purpose: To analyze the safety and efficacy of corneal photovitrification (CPV) for improved visions of age-related macular degeneration (AMD) eyes.
Study Design: Using CPV for improved visions of AMD eyes.
Place and Duration of Study: New Taipei City, Taiwan, and Austin, TX, USA; between
April, 2022 and June, 2022.
Methodology: The CPV efficacy is calculated based on the rate equation given by dM/dt=-k(t) M(t), where M(t) is the PCV-treated corneal stroma; and k(t) is the rate coefficient given by an Arrhenius formula, k(t) = A0 exp[−Ea/(RT(t,z)], where t and z are the laser irradiation time and depth of the cornea stroma; Ea is the activation energy and R is the gas constant. The temperature spatial and temporal profiles are given by the numerical solutions of a heat diffusion equation with a volume heating source. Various effective depths including the tissue damage depth, temperature penetration depth and conversion depth, governed by the tissue absorption coefficient, light intensity and dose (or irradiation time), and the related threshold values, are introduced in replacing the conventional penetration depth based on a Beer's law.
Results: The suggested protocol for CPV treatments include: a diode laser at about 2 µm wavelength (with absorption coefficient about 100 cm-1). The laser dose is about 25 J/cm2/spot and irradiation time of 150 ms.
Conclusion: The efficacy of CPV may be predicted/calculated by our modeling based on rate equation and the corneal stroma temperature rise due to laser heating. The preferred retinal locus (PRL) movement observed post-CPV is caused mainly by neuroadaptation.
Amplifying Molecular Scale Rotary Motion: The Marriage of Overcrowded Alkene Molecular Motor with Liquid Crystals
Authors: Lan Ruochen , Bao Jinying , Huang Rui , Wang Zizheng , Zhang Lanying , Shen Chen , Wang Qian , Yang Huai 
Published: June 2022

AbstractDesign and fabrication of macroscopic functional devices by molecular engineering is an emerging and effective strategy in exploration of advanced materials. Photoresponsive overcrowded alkene‐based molecular motor (OAMM) is considered as one of the most promising molecular machines due to the unique rotary motion driven by light with high temporal and spatial precision. Amplifying the molecular rotary motions into macroscopic behaviors of photodirected systems links the molecular dynamics with macroscopic motions of materials, providing new opportunities to design novel materials and devices with a bottom‐up strategy. In this review, recent developments of the light‐responsive liquid crystal system triggered by OAMM will be summarized. The mechanism of amplification effect of liquid crystal matrix will be introduced first. Then progress of the OAMM‐driven liquid crystal materials will be described including light‐controlled photonic crystals, texture‐tunable liquid crystal coating and microspheres, photoactuated soft robots, and dynamic optical devices. It is hoped that this review provides inspirations in design and exploration of light‐driven soft matters and novel functional materials from molecular engineering to structural modification.
Dynamic Surface Evolution of Metal Oxides for Autonomous Adaptation to Catalytic Reaction Environments
Authors: Kim Jun Kyu , Kim Sangwoo , Kim Seunghyun , Kim Hyung Jun , Kim Kyeounghak , Jung WooChul , Han Jeong Woo 
Published: June 2022

AbstractMetal oxides possessing distinctive physical/chemical properties due to different crystal structures and stoichiometries play a pivotal role in numerous current technologies, especially heterogeneous catalysis for production/conversion of high‐valued chemicals and energy. To date, many researchers have investigated the effect of the structure and composition of these materials on their reactivity to various chemical and electrochemical reactions. However, metal oxide surfaces evolve from their initial form under dynamic reaction conditions due to the autonomous behaviors of the constituent atoms to adapt to the surrounding environment. Such nanoscale surface phenomena complicate reaction mechanisms and material properties, interrupting the clarification of the origin of functionality variations in reaction environments. In this review, the current findings on the spontaneous surface reorganization of metal oxides during reactions are categorized into three types: 1) the appearance of nano‐sized second phase from oxides, 2) the (partial) encapsulation of oxide atoms toward supported metal surfaces, and 3) the oxide surface reconstruction with selective cation leaching in aqueous solution. Then their effects on each reaction are summarized in terms of activity and stability, providing novel insight for those who design metal‐oxide‐based catalytic materials.
Tailoring Materials for Epilepsy Imaging: From Biomarkers to Imaging Probes
Authors: Zhao Jing , Wang Cong , Sun Wanbing , Li Cong 
Published: June 2022

AbstractExcising epileptic foci (EF) is the most efficient approach for treating drug‐resistant epilepsy (DRE). However, owing to the vast heterogeneity of epilepsies, EF in one‐third of patients cannot be accurately located, even after exhausting all current diagnostic strategies. Therefore, identifying biomarkers that truly represent the status of epilepsy and fabricating probes with high targeting specificity are prerequisites for identifying the “concealed” EF. However, no systematic summary of this topic has been published. Herein, the potential biomarkers of EF are first summarized and classified into three categories: functional, molecular, and structural aberrances during epileptogenesis, a procedure of nonepileptic brain biasing toward epileptic tissue. The materials used to fabricate these imaging probes and their performance in defining the EF in preclinical and clinical studies are highlighted. Finally, perspectives for developing the next generation of probes and their challenges in clinical translation are discussed. In general, this review can be helpful in guiding the development of imaging probes defining EF with improved accuracy and holds promise for increasing the number of DRE patients who are eligible for surgical intervention.
Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet‐Resistant Bioelectrode Applications
Authors: Huang Jing‐Ju , Lin Chia‐Hsuan , Tanaka Yukiko , Yamamoto Aki , Luo Shyh‐Chyang , Tanaka Masaru 
Published: June 2022

AbstractPoly(3,4‐ethylenedioxythiophene) (PEDOT) and its derivatives have demonstrated potential in the development of bioelectrodes because of their superior conductivity. However, developing reliable implanted bioelectrodes requires improvements in biocompatibility and the prevention of nonspecific adhesion. In this study, a six ethylene glycol (EG)‐functionalized EDOTs with three different EG lengths (tri‐EG, tetra‐EG, and hexa‐EG) and two types of end groups, hydroxyl (−OH) and methoxy (−OCH3) is synthesized and systematically investigated. By coating them on gold electrodes using electropolymerization, the surface and electrochemical properties of these functionalized PEDOT‐coated electrodes are investigated. Although PEDOT with −OH groups on the surface is more hydrophilic, those with −OCH3 groups on the surface exhibit higher electrochemical activity and lower impedance. The increase in EG units and −OCH3 groups on the surface effectively reduces the adhesion between the PEDOT and atomic force microscopy tips. PEDOT with longer EG lengths and −OCH3 groups exhibits relatively few adhered platelets, and the results of the analysis of hydrated states through differential scanning calorimetry are consistent with those of the platelet adhesion test. This study suggests that a tetra(EG)‐functionalized PEDOT with −OCH3 groups on the surface is a promising coating for implanted bioelectrode applications.
Transparent and Breathable Ion Gel‐Based Sensors toward Multimodal Sensing Ability
Authors: Isano Yuji , Fujita Hajime , Murakami Koki , Ni Sijie , Kurotaki Yuta , Takano Tamami , Isoda Yutaka , Matsuda Ryosuke , Nakamura Fumika , Nishitai Yuuki , Ochirkhuyag Nyamjargal , Inoue Kota , Kawakami Hiroki , Okubo Yusuke , Ueno Kazuhide , Fujie Toshinori , Ota Hiroki 
Published: June 2022

AbstractPolymer thin‐film sensors have attracted considerable attention in various applications owing to their highly transparent, flexible, and gas‐permeable features. However, conventional thin‐film sensors based on nanomaterials suffer from poor selectivity in sensing targets and scalability of functions. Therefore, a new approach is required for achieving higher selectivity with simple processibility. This study proposes highly transparent, ultra‐flexible, and gas‐permeable polymer thin‐film sensors using ion gels as the sensing material; the sensors demonstrated the capacity for selective detections. Particularly, this study demonstrates simultaneous and independent sensing of temperature and humidity as a proof of concept. The sensors are fabricated using a simple spray coating method on a thin silicone rubber film (≈25 µm thickness). Owing to their thin‐film shape, the sensors exhibit more than 80% visible light transmittance and a higher gas permeability than the human transepidermal water loss. The temperature and humidity are simultaneously detected with a high sensitivity of 15.4% °C–1 and 2.0% per percentage of the relative humidity, respectively, using gels containing two different ionic liquids (ILs). The results suggest that the easily modifiable nature of ILs enables the fabrication of ultra‐flexible and transparent sensors that can detect various objects using a simple method.
Exceedingly Stable Luminescent Dinuclear Pt(II) Complexes with Ditopic Formamidinate Bridging Ligands for High‐Performance Red and Deep‐Red OLEDs with LT97up to 2446 h at 1000 cd m−2
Authors: Xue Minying , Lam Tsz‐Lung , Cheng Gang , Liu Weiqiang , Low Kam‐Hung , Du Lili , Xu Shuo , Hung Faan‐Fung , Phillips David Lee , Che Chi‐Ming 
Published: June 2022

AbstractThe utilization of triplet metal‐metal‐to‐ligand‐charge‐transfer (3MMLCT) emissions of Pt(II) complexes having a large radiative decay rate is a promising strategy to develop efficient red and deep‐red emitters for practical organic light‐emitting diodes (OLEDs). The panel of robust luminescent dinuclear Pt(II) emitters described here features pyridine‐/pyrazine‐fused N‐heterocyclic carbene‐based cyclometalating ligands and ditopic bis‐µ2‐formamidinate bridging ligands. These complexes show intramolecular Pt–Pt distances of 2.85–2.87 Å, are thermally stable up to 446 °C, and display strong red and deep‐red3MMLCT emission (604–689 nm) with emission quantum yields close to unity. Under laboratory conditions, red and deep‐red OLEDs with these complexes show high external quantum efficiencies (up to 21.3%) and prolonged operational lifetimes (LT97up to 2446 h) at an initial luminance of 1000 cd m−2, highlighting the practicality of these dinuclear Pt(II) emitters in organic optoelectronics application.
Two‐Dimensional Tellurene Transistors with Low Contact Resistance and Self‐Aligned Catalytic Thinning Process
Authors: Lin Ziyuan , Wang Jingli , Chen Jiewei , Wang Cong , Liu Jidong , Zhang Wenjing , Chai Yang 
Published: June 2022

AbstractTwo‐dimensional (2D) tellurene (Te) has shown its great potential in nanoelectronics for its high carrier mobility and air stability. However, the high‐resistance electrical contact and relatively thick Te channel hinder its ultimate scaling and device performance. Here, the transport property of Te field‐effect transistors using platinum (Pt) contact with high work function is studied, which facilitates the effective hole injection in the p‐type Te channel. The electrical contact to Te using the Y‐function method (YFM) and the transmission line method (TLM) is investigated. The Te transistors with Pt contact show a low contact resistance of 400 Ωµm, a short transfer length of 80 nm, and low specific contact resistivity of 3.2 × 10−7 Ωcm2, resulting from the low Schottky barrier height (SBH) of Pt/Te interface. The Pt electrode also can work as an efficient catalyst that allows reduction of the Te channel thickness with a controllable thinning process in water under white light illumination. This self‐aligned catalytic thinning process enables the construction of the transistors with a thin Te channel and thick Te contact with Pt metal electrodes, which provides a device configuration with both effective electrostatic control and low contact resistance.
Factors driving burnout and professional fulfillment among emergency medicine residents: A national wellness survey by the Society for Academic Emergency Medicine
Authors: Sakamoto Jeffrey T. , Lee Justin , Lu Dave W. , Sundaram Vandana , Bird Steven B. , Blomkalns Andra L. , Alvarez Al'ai 
Published: June 2022

AbstractObjectivesThis study aimed to identify rates of and contributors to burnout and professional fulfillment among emergency medicine (EM) resident physicians.MethodsThis was a cross‐sectional, national survey of resident members of the Society for Academic Emergency Medicine (SAEM). Primary outcomes were burnout and professional fulfillment measured using a previously validated instrument with additional domains pertaining to the academic environment. The survey included question domains examining organizational factors (e.g., academic work environment, satisfaction with training, electronic health records, values alignment, and control over schedule) and individual factors (e.g., self‐compassion, meaningfulness of clinical work, impact of work on health and personal relationships, perceived appreciation, thoughts of attrition, and expectations of the field of EM). Logistic regression was performed to determine the relationships between the primary outcomes and each domain.ResultsThe survey was sent electronically to 2641 SAEM resident members. A total of 275 residents completed the survey with a response rate of 10.4%. A total of 151 (55%) respondents were male, and 210 (76%) were White. A total of 132 (48%) residents reported burnout, and 75 (28%) reported professional fulfillment. All organizational and individual factors were significantly associated with both primary outcomes. EM residents reported that meaningfulness of clinical work had the most significant positive association with professional fulfillment (adjusted odds ratio [OR] 2.2 [95% confidence interval {CI} 1.8–2.7]) and negative association with burnout (adjusted OR 0.46 [95% CI 0.37–0.56]). Thoughts of attrition from academics and accurate expectations of EM were also associated with both primary outcomes, with adjusted ORs (95% CIs) of 0.40 (0.21–0.72) and 5.6 (1.9–23.8) for professional fulfillment and 4.1 (2.5–7.1) and 0.19 (0.08–0.40) for burnout, respectively.ConclusionsThis study found a high prevalence of burnout and a low prevalence of professional fulfillment among EM residents. Multiple factors were significantly associated with each occupational phenomenon, with meaningfulness of clinical work demonstrating the strongest relationships with burnout and professional fulfillment.
Organocatalytic Asymmetric Reaction between α‐Cyano Enones and Dioxindoles: Synthesis of Dihydrofuran‐Spirooxindoles
Authors: Biswas Subhankar , Balha Megha , Das Suman , Chandra Pan Subhas 
Published: June 2022

AbstractAn organocatalytic enantioselective synthesis of dihydrofuran‐spirooxindoles has been developed. Dioxindoles and trans‐α‐cyano‐α,β‐unsaturated ketones were engaged as the reaction partners in this method. The desired products were obtained via bifunctional squaramide catalyzed Michael reaction followed by Pinner reaction and isomerization.