bluuebunny/crossref_metadata_2025_split huggingface dataset:
Night shift work characteristics are associated with several elevated metabolic risk factors and immune cell counts in a cross-sectional study
Authors: Streng Astrid A. , Loef Bette , Dollé Martijn E. T. , van der Horst Gijsbertus T. J. , Chaves Inês , Proper Karin I. , van Kerkhof Linda W. M. 
Published: February 2022

AbstractNight shift work is associated with increased health risks. Here we examined the association of metabolic risk factors and immune cell counts, with both night shift work and particular characteristics thereof: frequency, duration and consecutive night shifts. We performed a cross-sectional study using data from 10,201 non-shift workers and 1062 night shift workers of the Lifelines Cohort study. Linear regression analyses, adjusted for demographic, lifestyle and occupational factors, were used to study associations of night shift work characteristics with metabolic risk factors and immune cell counts. Night shift workers had an increased BMI, waist circumference and immune cell counts compared to non-shift workers. This was especially seen in night shift workers who had a higher frequency of night shifts per month (≥ 5: BMI: B = 0.81 kg/m2 (95%-CI = 0.43–1.10); waist circumference: B = 1.58 cm (95%-Cl = 0.34–1.71; leukocytes: B = 0.19 × 109 cells/L (95%-CI = 0.04–0.34 × 109)) and worked more consecutive night shifts (> 3: BMI: B = 0.92 kg/m2 (95%-CI = 0.41–1.43); waist circumference: B = 1.85 cm (95%-Cl = 0.45–3.24); leukocytes: B = 0.32 × 109 cells/L (95%-CI = 0.09–0.55 × 109)). This association was less pronounced in long-term night shift workers (≥ 20 years). Our findings provide evidence for the association between night shift work characteristics and BMI, waist circumference and leukocytes (including, monocytes, lymphocytes, and basophil granulocytes).
Online Discussions About Tinnitus: What Can We Learn From Natural Language Processing of Reddit Posts?
Authors: Manchaiah Vinaya , Londero Alain , Deshpande Aniruddha K. , Revel Manon , Palacios Guillaume , Boyd Ryan L. , Ratinaud Pierre 
Published: February 2022

Background:
This study was aimed at identifying key topics in online discussions about tinnitus by examining a large data set extracted from Reddit social media using a natural language processing technique.

Method:

A corpus of 113,215 posts about tinnitus was extracted from Reddit's application programming interface. After cleaning the data for duplications and posts without any text information, the sample was reduced to 101,905 posts, which was subjected to cluster analysis using the open-source IRaMuTeQ software to identify main topics based on the co-occurrence of texts. These clusters were named by a panel of tinnitus experts (
n
= 9) by reading typical text segments within each cluster.

Results:
The cluster analysis identified 16 unique clusters that belong to two topics, which were named “tinnitus causes and consequences” and “tinnitus management and coping.” Based on their characteristics, the clusters were named: tinnitus timeline (10%), tinnitus perception (9.7%), medical triggers and modulators (8.8%), hearing research (8.8%), attention and silence (8.6%), social media posts about tinnitus (7.4%), hearing protection (7.3%), interaction with hearing health care providers (6.7%), mental health and coping (5.8%), music listening (5.7%), hope for a cure (5.6%), interactions with people without tinnitus (5.4%), dietary supplements and alternative therapies (3.2%), sleep (3.9%), dietary effects (1.7%), and writing about tinnitus and being thankful to online community (1.4%).

Conclusions:
Despite some limitations, tinnitus posts on Reddit provide rich real-world data to identify various issues and complaints that tinnitus patients and their significant others discuss in online communities. Some of the clusters identified here are novel (e.g., tinnitus timeline, interactions with people without tinnitus) and have not been much discussed in the tinnitus literature. The results suggest that individuals with tinnitus relay on social media for support and highlight the service delivery needs in providing social support through other means (e.g., support groups).
Detecting Developmental Language Disorder in Monolingual and Bilingual Children: Comparison of Language-Specific and Crosslinguistic Nonword Repetition Tasks in French and Portuguese
Authors: Schwob Salomé , Skoruppa Katrin 
Published: February 2022

Purpose:Over the last decades, many studies have documented the clinical potential of nonword repetition (NWR) tasks for detecting developmental language disorder in mono- (MON) and bilingual (BIL) children by unveiling their difficulties in short-term memory and phonological accuracy. However, the precise nature of the nonwords to be used and the best scoring methods remain under debate. Some authors (e.g., Gutiérrez-Clellen & Simon-Cereijido, 2010) support the use of “language-specific” nonwords designed for a given test language in standardized tests. Other authors (e.g., Chiat, 2015) advocate the use of “crosslinguistic” stimuli, thus allowing assessment independently of the languages spoken by the child.Method:This research note compares two language-specific tasks (French vs. Portuguese) and a crosslinguistic NWR task in a population of 5- to 7-year-old MON and BIL children. Group comparisons (children with vs. without developmental language disorder; MON vs. BIL children), an error analysis, sensitivity and specificity calculations (assessed according to the recommendations of Plante and Vance, 1994, and Youden, 1950) are reported.Results:All three tasks significantly differentiate children with and without developmental language disorder with large effect sizes but did not show an effect for bilingualism, which is encouraging for the BIL assessment. As expected, an influence of children's age and length and complexity of the stimuli was also found. The language-specific French task was found to be the most sensitive (max. 88%) and specific (max. 92%); the crosslinguistic task also reached good accuracy percentages for the BIL group (max. 82% sensitivity and 84% specificity).Conclusion:This research note adds to the evidence that NWR tasks are promising tolls for the identification of MON and BIL children with developmental language disorder.Supplemental Material:https://doi.org/10.23641/asha.19111628
Hydrophilic polymer‐coated PVC surface for reduced cell and bacterial adhesions
Authors: Almousa Rashed , Wen Xin , Na Sungsoo , Anderson Gregory , Xie Dong 
Published: February 2022

AbstractHydrophilic polymers are very useful in biomedical applications. In this study, biocompatible polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) polymers end‐capped with succinimidyl groups were either modified or synthesised and attached to polyvinylchloride surfaces. The modified surfaces were evaluated with cell adhesion and bacterial adhesion. 3T3 mouse fibroblast cells and three bacteria species were used to evaluate surface adhesion activity. Results showed that the modified surface exhibited significantly reduced 3T3 cell adhesion with a 50%–69% decrease for PEG and a 64%–81% for PVP, as compared to unmodified polyvinylchloride. The modified surface also showed significantly reduced bacterial attachment with 22%–78%, 18%–76% and 20%–75% decrease for PEG and 22%–76%, 18%–76% and 20%–73% for PVP to Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, respectively, as compared to unmodified polyvinylchloride. It seems that an appropriate chain length or molecular weight (neither the longest nor the shortest chain length) determines the lowest cell and bacterial adhesion in terms of PEG. On the other hand, a mixture of polymers with different chain lengths exhibited the lowest cell and bacterial adhesion in terms of PVP.
Research on trajectory planning and control system of general mobile platform for Mountain Orchard
Authors: Bao Xiulan , Mao Jincheng , Dai Peng , Gong Zheng , Li Shanjun , Chen Hong 
Published: February 2022

AbstractTo solve the problems of agricultural machinery simplification, lack of universality and uneven land in mountain orchards, a light self‐propelled universal mobile platform for mountain orchards is studied in this paper. A light crawler chassis, an electric drive system and a multi‐sensor control system are designed. Through the kinematics and dynamics modelling of the general platform, the prediction model of the motion system of the general mobile platform is determined. Then the observation model of the system motion is determined based on the multi‐sensor fusion, and the multi‐sensor fusion navigation control system is established. Based on the energy consumption model of mobile platform, the energy consumption optimal trajectory planning is carried out. The energy consumption optimal trajectory radius is 2.5 m and the deflection angle is 36.9°, and the optimal trajectory radius of energy consumption is 1.9 m. Orchard experiments show that the maximum lateral displacement deviation of the universal mobile platform is less than 0.1 m, which can basically achieve the expected trajectory autonomous walking function.
MeerKAT view of the diffuse radio sources in Abell 3667 and their interactions with the thermal plasma
Authors: de Gasperin F. , Rudnick L. , Finoguenov A. , Wittor D. , Akamatsu H. , Brüggen M. , Chibueze J. O. , Clarke T. E. , Cotton W. , Cuciti V. , Domínguez-Fernández P. , Knowles K. , O’Sullivan S. P. , Sebokolodi L. 
Published: February 2022

Context. During their lifetimes, galaxy clusters grow through the accretion of matter from the filaments of the large-scale structure and from mergers with other clusters. These mergers release a large amount of energy into the intracluster medium (ICM) through merger shocks and turbulence. These phenomena are associated with the formation of radio sources known as radio relics and radio halos, respectively. Radio relics and halos are unique proxies for studying the complex properties of these dynamically active regions of clusters and the microphysics of the ICM more generally.
Aims. Abell 3667 is a spectacular example of a merging system that hosts a large pair of radio relics. Due to its proximity (z = 0.0553) and large mass, the system enables the study of these sources to a uniquely high level of detail. However, being located at Dec = −56.8°, the cluster could only be observed with a limited number of radio facilities.
Methods. We observed Abell 3667 with MeerKAT as part of the MeerKAT Galaxy Cluster Legacy Survey. We used these data to study the large-scale emission of the cluster, including its polarisation and spectral properties. The results were then compared with simulations.
Results. We present the most detailed view of the radio relic system in Abell 3667 to date, with a resolution reaching 3 kpc. The relics are filled with a network of filaments with different spectral and polarisation properties that are likely associated with multiple regions of particle acceleration and local enhancements of the magnetic field. Conversely, the magnetic field in the space between filaments has strengths close to what would be expected in unperturbed regions at the same cluster-centric distance. Comparisons with magnetohydrodynamic cosmological and Lagrangian simulations support the idea of filaments as multiple acceleration sites. Our observations also confirm the presence of an elongated radio halo, developed in the wake of the bullet-like sub-cluster that merged from the south-east. Finally, we associate the process of magnetic draping with a thin polarised radio source surrounding the remnant of the bullet’s cool core.
Conclusions. Our observations have unveiled the complexity of the interplay between the thermal and non-thermal components in the most active regions of a merging cluster. Both the intricate internal structure of radio relics and the direct detection of magnetic draping around the merging bullet are powerful examples of the non-trivial magnetic properties of the ICM. Thanks to its sensitivity to polarised radiation, MeerKAT will be transformational in the study of these complex phenomena.
Substanzkonsum – Sucht – Gewalt:
Zusammenhänge, Risiken, Prävention
Authors: Klein Michael 
Published: February 2022

ZusammenfassungZwischen Substanzkonsum und Gewaltverhalten besteht ein enger Zusammenhang, der
durch Schlüsselsituationen, veränderte Risikowahrnehmung und
-beurteilung sowie verminderte Aggressionshemmungen gekennzeichnet ist. Zu den
aktuellen Konzepten zur Einschätzung des Zusammenhangs zwischen
Substanzkonsum und Gewalt zählt das I3-Modell, das die Faktoren
Anstiftung, Schlagkraft und Hemmung in einen Zusammenhang zwischen der
konsumierenden Person und der Risikosituation bringt. Inzwischen liegen
Programme zur Prävention und Intervention bei suchtmittelassoziierter
Gewalt vor, wie z. B. TAVIM, die im Behandlungssystem stärkere
Verankerung erfahren sollten.
The Scope of HbA1c Variability and Risk of Vascular Complications
Among Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of
Prospective Studies
Authors: Guo Kai , Zhao Qian , Wang Meng , Lu Yuchun , Wo Meihong , Zhou Xiaoyan , Ying Changjiang 
Published: February 2022

AbstractGlycated hemoglobin (HbA1c) variability is emerging as an indicator of long-term
glycemic control, which may play a significant role during vascular
complications. We conducted a systematic review and meta-analysis to assess the
association between the scope of HbA1c variability and vascular complications in
patients with type 2 diabetes mellitus. PubMed and Embase were searched for
studies that evaluated the association of HbA1c variability with vascular
complications in patients with type 2 diabetes. Two reviewers independently
completed data extraction. Random-effects meta-analysis was conducted with
stratification according to the type of vascular complications. Nine studies
were eligible for inclusion in our systematic review and meta-analysis. Six
studies evaluated the impact of the standard deviation of HbA1c (HbA1c-SD) on
cardiovascular events and showed an association of HbA1c-SD with cardiovascular
events (HR: 1.25, 95% CI 1.18–1.32, 5 studies). Six studies
evaluated renal disease associated with HbA1c-SD and showed that HbA1c-SD was
correlated with an increased risk of renal disease (HR: 1.19, 95% CI
1.13–1.24). Two studies evaluated HbA1c-SD and the risk of retinopathy
and showed that no significant association was found between retinopathy and
HbA1c-SD (HR 1.08, 95% CI 0.92–125). For HbA1c-SD ranging from
0.6 to 0.8%, HbA1c-SD was associated with an increased risk of
cardiovascular events (HR: 1.25, 95% CI 1.15–1.35) and renal
disease (HR: 1.16, 95% CI 1.11–1.22). For individuals with index
HbA1c variability greater than or equal to 0.6%, HbA1c variability was
significantly associated with vascular complications in patients with type 2
diabetes mellitus.
Towards Tianeptine Analogues: Synthesis of New Ring Systems Containing a Dibenzo[c,f][1,2]thiazepine S,S-Dioxide Core
Authors: Volk Balázs , Berecz Gábor , Dancsó András , Németh Dóra R. , Kiss Loránd , Simig Gyula 
Published: February 2022

AbstractIn the course of the synthesis of fused-ring analogues of the antidepressant drug tianeptine, representatives of three new heterocyclic ring systems, indolo[1,7-bc][1,2]benzothiazepines (and their 4,5-dihydro analogues), 5,6-dihydroquino[1,8-bc][1,2]benzothiazepines, and [1,2]benzothiazepino[4,3,2-jk]carbazoles, as well as their intermediates, have been prepared. The tetracyclic and pentacyclic ring systems containing either an oxo or a hydroxy functional group are suitable for introducing various side chains, including potential pharmacophores. For this latter transformation, examples are demonstrated by conversion of the hydroxy group into a chloro moiety and subsequent reaction with amines or with primary alcohols bearing a tertiary amino side chain. Two fused-ring derivatives exhibiting the side-chain characteristics of tianeptine have also been synthesized. Altogether 40 compounds are described in the present manuscript, eight of them are also characterized by single-crystal X-ray diffraction.
Prognostic Value of Inflammation-based Prognostic Scores in Patients with Colorectal Cancer
Authors: Afonso João Pedro Lima , Pereira Ana , Pereira Joaquim Costa , Martins Sandra F. 
Published: February 2022

AbstractBackground Anatomopathological staging is the primary method to determine the prognosis of patients with colorectal carcinoma (CRC). However, new tools have been developed that can complement it, such as the analysis of the elevation of systemic inflammatory markers.Objective To evaluate the impact of the elevation of scores based on inflammatory markers (the neutrophil-to-lymphocyte ratio [NLR], the Glasgow Prognostic Score [GPS], and isolated C-reactive protein [CRP]) in the prognosis of patients diagnosed with CRC and submitted to potentially curative surgery in Hospital de Braga, Portugal, between January 1st, 2005, and December 31st, 2010.Methods A retrospective analysis of the data of 426 patients was performed, with a collection of several clinico-pathological variables, as well as the levels of lymphocytes, neutrophils, albumin and CRP, in the pre- and postoperative periods, to apply the different scores to the sample.Results From the analysis of the survival curves, we concluded that patients with increased NLR in the pre- and postoperative periods present a lower cancer-related survival than patients with normal NLR (preoperative period: 93.7 versus 122 months; p < 0.001; postoperative period: 112 versus 131 months; p = 0.002). Patients with increased NLR in the pre- and postoperative periods also had a lower disease-free survival (preoperative period: 88.0 versus 122 months; p < 0.001; postoperative period: 111 versus 132 months; p = 0.002). In addition, increased pre- and postoperative NLR was associated with a higher risk of death due to CRC (preoperatively: hazard ratio [HR] = 2.25; p < 0.001; postoperatively: HR = 2.18; p = 0.003). However, the multivariate analysis shows that only postoperative NLR (ajusted HR = 2.66; p = 0.002) does so independently of the remaining variables.Conclusion Regarding the scores applied to the sample, the NLR was the one that most consistently related to the prognosis of the patients. However, it would be useful to develop a prospective study that could confirm this relationship.
The Ligation of the Intersphincteric Fistula Tract (LIFT) Technique for Simple and Complex Fistula-in-ano
Authors: Kumar Manoj , Kumar Manoj , Arora Abhishek , Ranjan Alok , Kant Kumar Chandra , PP Sreepriya 
Published: February 2022

Abstract
Background Fistula-in-ano is one of the most common clinical condition encountered in a surgical outpatient department. Many treatment modalities have been described with variable outcomes but gold standard surgical treatment is yet to be agreed upon. The aim of the present study is to evaluate the treatment outcomes of ligature of intersphincteric fistula tract (LIFT) technique in the treatment of simple and complex fistula-in-ano with the primary objective of recurrence rate and broad objective of other postoperative complications during the period of study and after long-term follow-up.
Methods It is a retrospective study of prospectively collected data from the patients who have been operated for fistula-in-ano using the LIFT technique at our institute from February 2018 to March 2020 and followed-up until September 2020.
Results A total of 56 patients with fistula-in-ano were treated with the LIFT procedure during the study period, of which 20 patients had simple fistula and 36 had complex fistula. A success rate of 83% was obtained with completely healed fistulas in 46 patients. No patient developed postoperative incontinence.
Conclusion Ligature of intersphincteric fistula tract is an effective treatment modality for fistula-in-ano with less procedure-related morbidity, but it is associated with a higher recurrence rate in simple fistula than in complex fistula.
Novel microsatellites and investigation of faecal DNA as a non-invasive population monitoring tool for the banded hare-wallaby (
Authors: Cowen Saul , Smith Michael , McArthur Shelley , Rayner Kelly , Jackson Chantelle , Anderson Georgina , Ottewell Kym 
Published: February 2022

Monitoring programs for populations of small or medium-sized animals often use live-capture or photo-monitoring trapping methods to estimate population size. The banded hare-wallaby (Lagostrophus fasciatus), a small macropodiform marsupial, does not readily enter traps or have individually unique distinguishing physical features and is consequently difficult to monitor using these methods. Isolating DNA from faecal material to obtain individual genotypes is a promising monitoring technique and may present an alternative approach for this species. We developed novel species-specific microsatellite markers and undertook trials to assess faecal DNA degradation in ambient environmental conditions at two locations where this species has been translocated. The quality of DNA yielded from faecal pellets was evaluated through amplification failure and genotyping error rates of microsatellite markers. Error rates were compared for different treatments and exposure duration across multiple individuals. DNA was successfully obtained from all samples and error rates increased with exposure duration, peaking after 14–30 days depending on the site and treatment. The level of solar exposure was the most significant factor affecting degradation rate but both this and exposure duration had significant effects on amplification failure. Analysing DNA obtained from faecal pellets may represent a practical non-invasive method of deriving population estimates for this species and warrants further development.
Intravesical delivery of
KDM6A
-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer
Authors: Kong Na , Zhang Ruonan , Wu Gongwei , Sui Xinbing , Wang Junqing , Kim Na Yoon , Blake Sara , De Diba , Xie Tian , Cao Yihai , Tao Wei 
Published: February 2022

Significance
This study provides proof-of-principle evidence for intravesical delivery of messenger RNA (mRNA) via a mucoadhesive nanoparticle (NP) strategy and reveals the therapeutic potential of KDM6A in treating bladder cancer metastasis, which remains difficult due to the physiological bladder barriers. The mucoadhesive NPs could protect loaded mRNA, prolong exposure of mRNA in disease sites, and benefit the penetration and effective expression, which all represent challenging hurdles for intravesical delivery of mRNA therapeutics. mRNA local delivery can also avoid potential toxicity issues via systemic delivery and unwanted protein expression throughout the body. We expect this mucoadhesive mRNA nanotechnology can be useful for the effective up-regulation of targeted proteins in bladder tissues in situ for both mechanistic understanding and translational study of bladder-related diseases.
Disentangling the individual and contextual effects of math anxiety: A global perspective
Authors: Lau Nathan T. T. , Hawes Zachary , Tremblay Paul , Ansari Daniel 
Published: February 2022

SignificanceUsing three large-scale international assessments of student achievement, the current study examined the antecedents of math anxiety and the relation between math anxiety and math achievement across the globe. Results suggest that individual math anxiety is negatively associated with math achievement across the globe. Importantly, we uncovered a contextual effect of math anxiety where the level of math anxiety in one’s educational peer group predicts math achievement above and beyond what could be predicted by one’s own math anxiety. Further, there is significant between-country variability in this contextual effect—only half of the examined countries’ contextual effect was statistically significant. Our results reveal an effect of educational peer’s math anxiety on math achievement and reinforce extant research findings.