bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHEMICAL CHANGES OF PUMPKIN SEED OILS AND THE IMPACT ON LIPID STABILITY DURING THERMAL TREATMENT: STUDY BY FTIR - SPECTROSCOPY
Authors: Rexhepi Fatos , Behrami Aziz , Samaniego-Sánchez Cristina , Rebezov Maksim , Shariati Mohammad Ali , Bastian da Silva Artur , Bertoli Sávio Leandro , Krebs de Souza Carolina 
Published: February 2022

Oxidative stability and fatty acid composition of the pumpkin seed oil (PSO) were studied, during roasting process from 80 to 150 °C and oil heat treatment (220 ˚C), by FTIR (Fourier - transform infrared) – Spectroscopy and GC/MS (Gas chromatography - mass spectrometry). The physicochemical parameters (density and iodine value) showed a significant increase (p < 0.05) during roasting, with a maximum value observed in the oil roasted at temperatures from 90 to 110 ˚C. The relative contents of polyunsaturated fatty acids (PUFAs) decreased to 87.7%, and saturated fatty acids (SFAs) increased to 112.5% at unroasted sample, after thermal treatment of oil samples. Especially at temperature 90 and 110 ˚C, oil samples have demonstrated that relative contents of PUFAs decreased to 95 % and SFAs increased to 101.6%. FTIR Spectroscopy provide to understand mechanism of chemical changes of seed during roasting process and, as result, which of obtained compounds are responsible for increasing thermal stability of oil lipids. In this study, it was observed that the best temperature for roasting pumpkin seeds is 110 ˚C, since at this point, both oxidation and Maillard reactions give rise to compounds with maximum antioxidant effect (lipid stability).
Analysis of Service Quality for CPNS Basic Training Providers (LatSar) at BPSDM Jambi Province in 2019
Authors: Musfarita Affiani  
Published: February 2022

The background of the research is the ineffectiveness of training which resulted in the low satisfaction of the training participants. Service quality includes reliability, responsiveness, assurance, empathy and tangibility. Efforts to improve service quality can be improved through service provision by referring to the dimensions of reliability, responsiveness, assurance, empathy and tangible, where assurance and empathy can be used as efforts to improve the quality of services that are more optimal for Finance. The aim of the research is to analyze the level of training management servqual. The analysis used is servqual analysis. The analysis of servqual on the management of the training showed that there was a significant gap between the trainee’s expectation with the training management.
Is Medieval French diglossic? New evidence on remnant V2 and register
Authors: Larrivée Pierre 
Published: February 2022

An ongoing debate concerns the degree of diglossia of contemporary French, by which vernacular and normative registers display significant grammatical differences. Was diglossia characterizing Medieval French? This question is explored through the study of unambiguous V2 configurations. The word order has been shown to display rates of use and informational behavior correlating to register. The correlation is investigated in novel data relating to narration vs. dialogue and to correspondence by members of different social classes. Quantitative analysis shows that variation in V2 behavior remains determined by formality. The proposed methods thus help measure diglossia of previous states of languages.
Improved Performance in Measurement of Serum Cystatin C by Laboratories Participating in the College of American Pathologists 2019 CYS Survey
Authors: Karger Amy B. , Long Thomas , Inker Lesley A. , Eckfeldt John H. ,   College of American Pathologists Accuracy Based Committee and Chemistry Resource Committee
Published: February 2022

Context.—
Use of cystatin C for glomerular filtration rate estimation (eGFR) has garnered heightened interest as a means to avoid race-based medicine, since eGFRcys equations do not require specification of race. Before considering more widespread use of cystatin C, it is important to confirm that assays provide accurate measurements of cystatin C concentration, to ensure accurate GFR estimates.

Objective.—
To determine if the accuracy of cystatin C measurements in laboratories participating in the College of American Pathologists (CAP) Cystatin C (CYS) survey has improved since 2014.

Design.—
Two fresh frozen serum pools, the first from healthy donors without chronic kidney disease (CKD), and the second from patients with CKD, along with a synthetically prepared elevated cystatin C pool, were sent to laboratories participating in the 2019 CYS-A survey. Target values were established by using 2 immunoassays and a bracketed 2-point calibration with diluted ERM-DA471/IFCC reference material.

Results.—
For the healthy donor fresh frozen pool (ERM-DA471/IFCC-traceable target of 0.725 mg/L), the all-method mean (standard deviation, coefficient of variation) was 0.731 mg/L (0.071, 9.7%). For the CKD pool (ERM-DA471/IFCC-traceable target of 2.136 mg/L), the all-method mean was 2.155 mg/L (0.182, 8.4%). For the synthetically spiked pool (ERM-DA471/IFCC-traceable target of 1.843 mg/L), the all-method mean was 1.886 mg/L (0.152, 8.1%). This represents marked improvement in accuracy and between-method agreement compared to the 2014 CAP survey.

Conclusions.—
Manufacturers have markedly improved accuracy and between-method agreement of cystatin C measurement procedures since 2014, which allows for greater confidence in estimated GFR relying on cystatin C.
Identification of sleep fragmentation-induced gut microbiota alteration and prediction of functional impact in Sprague Dawley rats harboring microbiome derived from multiple human donors
Authors: Triplett Judy , Braddock Amber , Roberts Erin , Ellis David , Chan Victor 
Published: February 2022

Objectives Poor quality sleep, including sleep fragmentation (SF), can result in severe health consequences. Gut microbiota symbiotically coexist with the host, making essential contributions to overall well-being. In this study, the effects of both acute (6-day) and chronic (6-week) SF in a humanized rat model were examined to evaluate the impact of SF on this symbiotic relationship.
Material and Methods Human fecal material was transplanted into antibiotic-treated, microbially depleted, Sprague Dawley rats. Animals were subjected to either acute or chronic SF and shifts to gut microbiota were investigated using 16S rRNA sequencing and predictive functional profiles were constructed with PICRUSt. We also investigated SF-induced intestinal microbial adhesion and penetration or increased microbial invasion of selected tissues and organs; as well as changes in crypt/villi architecture.
Results Microbiota profiling indicated that chronic, but not acute, SF significantly decreased the richness of alpha-diversity of distal ileum microbiota, and altered cecum and distal ileum beta-diversity; although both acute and chronic SF significantly changed select populations of microbiota in all three regions. Neither acute nor chronic SF induced changes to microbial adhesion, penetration, or invasion into intestinal tissues or nearby organs. Additionally, we found that chronic SF caused a reduction in villus height in the proximal colon.
Discussion Our study suggests that acute SF alters the gut microbiota in this humanized rat model, while chronic SF produces more pronounced changes to microbiota populations. This study identified potential microbiota targets for the prevention and/or intervention of the adverse effects of S F.
Early impact on sleep and mental health during the mandatory social isolation of COVID-19 outbreak: an obser vational cross-sectional study carried out in Argentina
Authors: Valiensi Stella Maris , Folgueira Agustín L. , Garay Arturo 
Published: February 2022

Introduction The mandatory social isolation (MSI) due to the pandemic caused by COVID-19 in the world produced many changes in sleep and different areas of mental health. Objectives: To evaluate the early effects of MSI on sleep, anxiety, and depression in Argentina.
Material and Methods An anonymous observational cross-sectional web-based study was distributed throughout the country and was completed by 2,594 respondents to analyze demographic information, quality of sleep, REM sleep-related events, depressive, and anxiety symptoms.
Results The study revealed that 53, 21, 22, 23, and 16% of people surveyed were poor sleepers, had dream-related behaviors, nightmares, depression, and anxiety symptoms, respectively. Multivariate logistic regression showed a positive correlation between anxiety, being a poor sleeper, and having nightmares.
Conclusion We identified the early effects of MSI on sleep quality, dreaming activity, anxiety, and depression in Argentina during the COVID-19 outbreak. Our findings can be used to formulate sleep and psychological interventions to improve mental health during the pandemic and post-pandemic times.
The changing profile of obstructive sleep apnea: long term trends in characteristics of patients presenting for diagnostic polysomnography
Authors: Marriott Ross J. , McArdle Nigel , Singh Bhajan , King Stuart , Ling Ivan , Ward Kim , Darcey Ellie , Bond-Smith Daniela , Mukherjee Sutapa , Palmer Lyle J. , Hillman David , Cadby Gemma 
Published: February 2022

Introduction We aimed to analyze long-term trends in characteristics of patients undergoing diagnostic polysomnography (PSG) and subsequently diagnosed with obstructive sleep apnea (OSA) to inform delivery of sleep services.
Material and Methods We studied 24,510 consecutive patients undergoing PSG at a tertiary-care sleep service between 1989 and 2013. OSA was defined by an apnea hypopnea index (AHI)≥ 5 events/hour. Changes to hypopnea definition and flow sensing techniques in 2002 created two distinct AHI scoring periods: American Sleep Disorders Association (ASDA) 1989 - July 2002 and American Academy of Sleep Medicine (Chicago) from August 2002.
Results Over 23.5 years there was a steady increase in proportion of females (15% to 45%), small increases in average age and BMI, and a small decline in socioeconomic status in the overall group. AHI varied between scoring periods both overall [ASDA 10.8/h (3.2-29.6), Chicago 24.3/h (11.8-48.1)] and in the large subgroup (80.7%) diagnosed with OSA [ASDA 20.7/h (10.6-44.1), Chicago 27.4/h (14.8-51.5)]. OSA diagnosis rates increased in the Chicago period (ASDA 66%, Chicago 91%). Increases in AHI and proportion diagnosed appeared better explained by changes in scoring methods than key OSA risk factors.
Conclusion Temporal increases in proportion of females and decreases in socioeconomic status of people undergoing PSG may reflect greater community awareness of sleep disorders. Temporal increases in age and obesity are consistent with secular trends. Changes in scoring methods have major impacts on OSA diagnosis and judgement of disease severity, with important implications for contemporary resourcing of sleep services and interpretation of historical OSA data.
Effectiveness of the Contours Vibes™ soothing vibrations infant and toddler crib mattress on infant and maternal sleep quality and health outcomes: an intervention study
Authors: Hausenblas Heather , Hooper Stephanie 
Published: February 2022

Objectives The purpose was to examine the effectiveness of the Contours Vibes™ Crib Mattress on infants’ and maternal sleep quality and health.
Material and Methods Participants were 24 mothers and their infants. For Week 1 the infants slept on their current mattress (Baseline). For Week 2 they slept on the Vibrating Mattress without using the vibrating feature (VMC). For Week 3 they slept on the Vibrating Mattress using the vibrating feature (VMA). Sleep quality and health assessments were completed at Baseline and following VMA and VMC conditions.
Results Sleep quality and health outcomes improved significantly for VMA compared to Baseline and VMC. VMC had significant improvements in some sleep and health outcomes compared to Baseline. No adverse events were reported.
Conclusion The mattress is a simple, noninvasive, and non-pharmacological intervention that improved infant and maternal sleep quality and health. Further research is need examining the longitudinal effects of the mattress.
Characterization of cyclic alternating pattern in infants with laryngomalacia
Authors: Cáceres Laura Mendoza , Vargas Ángel Daniel Santana , Rosas Gabriela Millán , Pérez Eduardo Barragán , Poblano Adrián , Miranda Rafael Santana 
Published: February 2022

Objective Cyclic alternanting pattern (CAP) has been considered a marker of sleep instability in children. The aim of this study was to evaluate the CAP in infants with laryngomalacia.
Material and Methods CAP were quantified in 15 infants with laryngomalacia (mean age 167.2±97.21 days) and 10 controls (mean age of 158.5±116.2 days) using polysomnography.
Results The distribution of the A2 subtypes across NREM stages in infants with laryngomalacia showed a decrease, as well as in the mean duration of CAP sequences. The A3 CAP and arousals increased in infants with laryngomalacia. Our data showed a stronger correlation between the mean duration of A1 CAP and the age in healthy controls than in infants with laryngomalacia. In accordance to previous reports infants with laryngomalacia exhibited an increase in total awake time, apnea-hypopnea index, and a decrease in N3 stage compared to controls.
Discussion Our findings add to a growing body of literature of CAP as an indicator of brain maturation
Impact of L-carnitine in narcolepsy treatment: a systematic review on the effectiveness and safety
Authors: Salles Cristina , Freitas Maria Clara , Cruz Miguel Meira e 
Published: February 2022

Introduction Studies have shown that narcolepsy patients may present with low serum acylcarnitine levels, demonstrating a dysfunctional beta fatty acid oxidation pathway in these patients.
Objective Evaluate the therapeutic efficacy of L-carnitine as a treatment for narcolepsy patients.
Methods This study runned in form of systematic review. The terms used for the search: (“narcolepsy”[MeSH Terms] OR “narcolepsy”[All Fields]) AND (“carnitine”[MeSH Terms] OR “carnitine”[All Fields] OR “l carnitine”[All Fields]). Were included all surveys published until January 2021, with the diagnosis of narcolepsy, that performed drug treatment with I-carnitine. The clinical endpoints of interest were: excessive daytime sleepiness, dissociative REM sleep manifestations: cataplexy, sleep paralysis, hypnagogic hallucinations, and early REM sleep (REM sleep naps, SOREMP).
Results L-carnitine was found to be well-tolerated and without side effects in all surveys, at dosages ranging from 500 to 510 mg/day. Newborns did not present complications during delivery.
Conclusion This study corroborates the efficacy and good tolerability of L-carnitine therapy as a treatment for patients with narcolepsy, including during pregnancy.
Sleeping together: understanding the association between relationship type, sexual activity, and sleep
Authors: Sprajcer Madeline , O’Mullan Catherine , Reynolds Amy , Paterson Jessica L. , Bachmann Alysa , Lastella Michele 
Published: February 2022

Objective Insufficient sleep, and particularly difficulties initiating sleep, are prevalent in the community. Treatment for poor sleep typically consists of pharmacological intervention, or cognitive behavioural therapies - which can be both costly and time-consuming. Evidence suggests that sexual activities may positively impact sleep. However, little is known about relationship types, sexual activities, and perceived sleep outcomes. The aim of this study was to explore the association between relationship type (e.g., having a regular, occasional, or casual partner), sexual activity and satisfaction, and perceived sleep outcomes, to identify potential strategies to improve sleep.
Methods Seven-hundred and seventy-eight participants aged 18 years and over (442 females, 336 males; mean age 34.5 ± 11.4 years) responded to a cross-sectional online anonymous survey at their convenience. Participants were asked about their sleep, sexual activity and satisfaction, and relationship type.
Results Results from multiple regression analyses with age and gender covariates revealed that shorter sleep latencies were associated with regular relationships (p = 0.030), greater emotional satisfaction with sexual activity (p = 0.029), and increased frequency of orgasm (p < 0.001). Men reported a greater frequency of orgasm than women (p < 0.001).
Discussion Findings indicate that relationship type may be associated with improved sleep outcomes, including sleep latency. Relationship type should therefore be taken into consideration by clinicians when developing treatment plans for individuals with poor sleep.
Effect of the anodal transcranial direct current electrical stimulation on cognition of medical residents with acute sleep deprivation
Authors: San-Juan Daniel , Mas Raúl Nathanael May , Gutiérrez Cuauhtémoc , Morales Jorge , Díaz Ana , Quiñones Gerardo , Galindo Axel Kevin , Baigts Luis Armando , Ximenez-Camilli Cecilia , Anschel David 
Published: February 2022

BACKGROUND Medical residents must sustain acute sleep deprivation, which can lead to nonfatal and fatal consequences in hospitals due to cognitive decline. Anodal transcranial direct current stimulation (a-tDCS) is a safe noninvasive neuromodulation technique that can induce depolarization of neurons. Previous studies in pilots have shown benefits against fatigue increasing wakefulness and cognitive performance. However, the effects of a-tDCS on cognition in acute sleep deprived healthcare workers remains unknown.
Purpose To evaluate cognitive changes in sleep deprived medical residents after one session of a-tDCS.
Methods Open clinical test-re-test study including 13 medical residents with acute sleep deprivation. Subjects received 1 session of bifrontal a-tDCS (2mAx20min), anodal over the left dorsolateral prefrontal region. Pre-and-post treatment subjects were tested with Beck anxiety inventory, Beck depression and HVLT tests, Rey´s and Taylor´s figures, Trail Making A/B, Stroop, Aleatory Digit retention test (WAIS), Digits and symbols and MoCA tests. Post-intervention was added the Executive functions and Frontal Lobes Neuropsychological Battery (BANFE2) test and changing the Taylor figure for Reyfigure.
Results Twelve medical residents were analyzed; 8 men and 4 women, 29.5 (+/-2.2) years mean age. All had a mean of 21.6 (+/-1.3) hours of sleep deprivation. There were no serious adverse events. We found statistically significant difference in Rey´s/Taylor´s figures (p=0.002), Trail Making Test (p=0.005), WAIS IV symbols (p=0.003), Word Stroop (p=0.021). BANFE-2 showed that the main affected area was the orbito-medial prefrontal region.
Conclusion a-tDCS appears safe and improves working memory, attention, response time and distractors elimination in acute sleep deprived medical residents.
When adherence to CPAP fails, how do we treat workers with obstructive sleep apnea?
Authors: Guimarães Maria de Lourdes Rabelo , Azevedo Pedro Guimarães , Barros-Vieira Sérgio , Elbaz Maxime , Leger Damien , Hermont Ana Paula 
Published: February 2022

Aims A cross-sectional study was designed to evaluate the effectiveness of a mandibular advancement device (MAD) with respect to respiratory and sleep parameters among miners with obstructive sleep apnea syndrome (OSAS) and primary snore.
Methods The target sample was composed by 102 Brazilian miners with a history of non-adherence to continuous positive airway pressure. All patients were treated with a MAD and underwent pre and post-treatment full-night polysomnography. Ethical approval and consents were obtained. Bivariate and logistic regression analyses were conducted. The level of statistical significance was set at 5%.
Results After the treatment with MAD, 71.8% of patients presented a decrease ≥ 50% in the basal apnea-hypopnea index (AHI), 51.2% presented an AHI < 5 events/h and 83.3% reached an AHI<10/h, whereas 22.5% did not show any changes and 7.5% of the sample presented an increase in the AHI (p<0.05). There was an increase in the mean SpO2 nadir (p<0.001) and in the baseline duration of the REM sleep stage (p<0.05). The MAD significantly decreased snore events (p<0.05). Multivariate analysis did not identify predictive factors related to therapy success (decrease ≥ 50% of AHI). However, basal AHI was a significant predictor related to the secondary endpoint (AHI<10/h) (OR= 1.06, IC 95%1.00-1.13, p=0.007).
Conclusions The MAD therapy showed significant improvements in AHI, minimum oxygen saturation, REM sleep and snoring.
Factors associated with excessive daytime sleepiness in informal drivers of buses on a high-altitude road
Authors: Olarte Ramón Julio Huamán , Ramos Willy , Mujica-Albán Elydia , Cruz-Vargas Jhony A. De La 
Published: February 2022

Objective To determine the factors associated with excessive daytime sleepiness (EDS) in informal interprovincial transport drivers of the Lima-Huancayo central highway (Peru) from January to March 2018.
Methods Cross-sectional study. The drivers were weighed and measured, then individual, sociodemographic, and occupational data were obtained which were recorded in a data collection form, then the Epworth Sleepiness Scale (ESS) was applied to the drivers. The prevalence and EDS-associated factors in drivers were obtained from this data. The multivariate analysis of the possible associated factors for EDS was performed with binary logistic regression, obtaining the adjusted odds ratio (AOR).
Results 162 drivers participated in the study. The average age was 42.0 ± 10.2 years (Range of 21-62 years), all the participants were male. 55. 6% had a technical degree, 42.0% were married and 55.6% had two to three children. The mean time of experience as a driver was 17.0 ± 6.8 years, 54.9% were overweight, and 32.1% were obese. 27.8% of drivers had EDS, the multivariate analysis found that the EDS-associated factors of the drivers were obesity (AOR=3.8, 95% CI: 1.422- 10.233), having 10 or more years of experience as a driver (AOR=3.1, 95% CI: 1.342-7.189) and overweight (AOR=2.9 CI 95%: 1.216-7.096).
Conclusion There is a high prevalence of EDS in informal drivers of interprovincial transport of the central high-altitude highway studied. Obesity was the main factor associated with EDS, along with being overweight and having 10 or more years of experience as a driver.