bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity of two doses of inactive COVID‐19 vaccine and third booster dose mRNA vaccine in patients with cancer receiving active systemic therapy
Authors: Guven Deniz Can , Incesu Fatma Gul Gulbahce , Yildirim Hasan Cagri , Erul Enes , Chalabiyev Elvin , Aktas Burak Yasin , Yuce Deniz , Arik Zafer , Kilickap Saadettin , Aksoy Sercan , Erman Mustafa , Hayran Kadir Mutlu , Unal Serhat , Alp Alpaslan , Dizdar Omer 
Published: September 2022

AbstractWe aimed to evaluate the seroconversion rates after two doses of inactive COVID‐19 vaccine (CoronaVac) and the benefit of a third dose mRNA vaccine booster in patients with cancer receiving active treatment. Patients with solid tumors receiving active treatment (n = 101) and patients with no‐cancer (n = 48) as the control group were included in the study. All the patients and controls had received two doses of CoronaVac and a third booster dose of the mRNA vaccine (Bnt162b2). Anti‐SARS‐CoV‐2 Spike Receptor Binding Domain IgG antibody levels after the second and third dose were measured with quantitative ELISA. The median age of the patients was 66 (IQR 60‐71). 79% of the patients were receiving chemotherapy, and 21% were receiving immunotherapy at the time of vaccination. Antibody levels measured after two doses of CoronaVac were significantly lower in patients with cancer than in the control group (median 0 μg/ml [IQR 0‐1.17 μg/ml] vs median 0.91 μg/ml [IQR 0‐2.24 μg/ml], respectively, P = .002). Seropositivity rates were 46.5% in patients with cancer and 72.9% in the control group (P = .002). Antibody measurement was performed in 26 patients after the third dose. Seroconversion rate increased from 46.5% to 88.5% (P < .001), and the antibody titers significantly increased with the third‐dose booster (median 0 μg/ml [IQR 0‐1.17 μg/ml] after two doses vs 12.6 μg/ml [IQR 1.8‐69.1 μg/ml] after third booster dose, P < .001). Immunogenicity of CoronaVac is low in patients with cancer receiving active treatment, and administering a third dose of an mRNA vaccine is effective in terms of improving seroconversion rates.
Green light for green credit? Evidence from its impact on bank efficiency
Authors: Galán Jorge E. , Tan Yong 
Published: September 2022

AbstractWe assess, for the first time in the literature, the impact of green credit on bank efficiency. We find that green credit has a negative impact on bank efficiency. However, the effect is heterogeneous among different types of banks. While small and low capitalized banks are more affected, the impact is lower in banks with higher levels of risk. On the other hand, we find that highly capitalized banks can offset the negative effects of green credit, while large banks and those highly involved in green credit, benefit from this activity.
Clinical examination of cattle. Part 2: calves, technology and ancillary testing
Authors: Sherwin Ginny , Nelson Rebecca , Kerby Mike , Remnant John 
Published: September 2022

Background:A systematic clinical examination of calves is key for reaching a diagnosis and creating a management plan for sick animals, with the principles of an individual animal clinical examination giving an indication of group‐level issues within the herd. The use of ancillary testing can aid in diagnosing different conditions in both youngstock and adult cattle, as well as determining the prognosis for the animal. This has become more accessible recently due to the developments in sensors and the application of diagnostic imaging, as well as calf‐side tests.Aim of the article:This article is the second in a two‐part series on undertaking a clinical examination of cattle. This article focuses on how to perform a clinical examination of a calf, at both an individual and a population level, and also discusses the role of technology and ancillary testing in aiding the clinical examination of both adult cattle and calves. Part 1 focused on examining adult dairy and beef cattle (Nelson and others 2022).
Additional stains and immunohistochemistry: what else can the pathologist tell us?
Authors: Priestnall Simon , Suárez‐Bonnet Alejandro 
Published: September 2022

Background: For the veterinary pathologist, the ‘bread and butter’ of our work is the tissue slide stained with haematoxylin and eosin (H&E). This has long become globally recognised as the ‘standard’ stain, with haematoxylin highlighting the nuclei of cells dark blue and eosin staining the cytoplasm pink. With experience, the pathologist can recognise and interpret many subtle changes in intensity, saturation and distribution of staining with H&E; for example, histopathological changes of degeneration or necrosis within cells can be identified and reported with H&E alone. Indeed, H&E is perhaps underappreciated as a highly valuable tool by pathologists and clinicians alike.The vast majority of routine cases, particularly those that are non‐neoplastic or of infectious aetiology, will not require more than H&E staining for making a complete histopathological diagnosis; however, there are times when microscopic changes or structures, recognised on H&E, either cannot be definitively diagnosed without an additional stain or, considering the clinical history and possible differentials, may be missed without one or more additional stains.Aim of the article: This article discusses the veterinary pathologist's approach to using special histochemical stains and immunohistochemistry to reach or confirm a histopathological diagnosis. It covers some of the common stains and antibodies and how and when they might be used.
Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect
Authors: Jiang Xin , Yan Nieng , Deng Dong , Yan Chuangye 
Published: September 2022

AbstractCancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation even in the presence of oxygen, and this is known as the “Warburg effect”. To accommodate the high glucose demands and to avoid lactate accumulation, the expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are elevated to maintain metabolic homeostasis. Therefore, inhibition of GLUTs and/or MCTs provides potential therapeutic strategies for cancer treatment. Here, we summarize recent advances in the structural characterization of GLUTs and MCTs, providing a comprehensive understanding of their transport and inhibition mechanisms to facilitate further development of anticancer therapies.
Research on sensing characteristics of third‐order runway series symmetric microring resonator based on hybrid plasma waveguide and metal insulator metal
Authors: Li Xin , Li Xieyuan , Zhang Haitao , Chen Shuang , Liu Shurong , Li Yang 
Published: September 2022

AbstractIn this paper, a high‐sensitivity refractive index sensor based on a hybrid plasma waveguide and metal–insulator–metal waveguide combined third‐order runway series mosaic microring resonator is proposed. In this structure, a GaAs waveguide ring surrounds a gold waveguide ring in the middle, and the innermost layer is a disk made of gold material. The outer groove waveguide is composed of GaAs‐air‐alloy, and the inner groove waveguide is made of the Gold‐Air‐Gold material disc. By filling different substances in the groove, the change of refractive index will affect the optical signal strength of the output spectrum. The finite element method simulates the transmission spectrum and electric field distribution of the sensor structure. The amplitude coupling coefficient and attenuation factor affecting the resonator's performance are analyzed, and the structural parameters of the slot waveguide are optimized. The numerical simulation results show that the sensor quality factor of this structure is 1.54 × 104, the sensitivity is 1.2 × 103 nm/RIU which is about 1.5 times higher than that of the Si ring with the same structure, the detection limit can reach 8.1892 × 10−7 RIU, and the free spectral range can reach 109 nm. Compared with the traditional microring structure, this microring has higher design freedom and free spectral range and is more suitable for producing biosensors with high sensitivity, low detection limit, and multi‐parameter measurement.
Are banking and accounting expertise on the audit committee related to bank loan terms?
Authors: Liu Pei‐Yi , Chin Chen‐Lung 
Published: September 2022

AbstractThe extant literature reveals that audit committee (AC) members with industry expertise can enhance the AC's effectiveness in monitoring the financial reporting process. In this study, we focus on AC banking and accounting expertise and examine their effects on bank loan contracting, respectively. We find that banks offer more favorable price term (i.e., interest rate) and non‐price terms (i.e., lower likelihood of providing collateral, more financial covenants, and longer maturity) to borrowers whose AC members have banking or accounting expertise. Second, we find that the association between AC expertise and loan terms is driven more by banking expertise, either alone or in conjunction with accounting expertise, than by accounting expertise alone. The results are robust to a battery of robustness tests. Overall, our results suggest that banks value borrowers’ AC banking experts as well as accounting expertise when designing loan terms.
A tentative integration of value stream mapping (VSM) and BPMN for improved process mapping
Authors: Soliman Marlon , Oliveira Esteves Otávio , Trevisan Mateus , Fogliarini Segatto Gabriel 
Published: September 2022

AbstractTo promote knowledge management and operations improvement, companies and organizations use different tools to map and analyze their processes, such as Value Stream Mapping (MFV) and Business Process Modeling and Notation (BPMN). However, each of these techniques has advantages and limitations, often requiring the same process to be mapped in more than one notation. To overcome this issue, this research aimed to explore how VSM and BPMN can be integrated for improving process mapping. Initially, we selected a business process for case study and mapped it with both VSM and BPMN notations. Then, we drawn a new process map using a tentative hybrid notation proposed by the authors that combine elements from both BPMN and VSM in a single depiction. For each process instantiation, we analyzed how the selected notation influences comprehension, treatment of complex processes, continuous improvement, and the use of performance metrics. Results show that the hybrid BPMN‐VSM notation has the potential to overcome many limitations reported in literature regarding the individual use of VSM or BPMN, while preserving the most valued characteristics of both. Although further developments are still necessary, the use of the proposed hybrid notation proved to be a promising alternative for mapping complex processes. To our knowledge, this is the first attempt to explore the possibility of a hybrid notation inspired from BPMN and VSM.
Metastatic skull base chordoma: A systematic review
Authors: Young Kurtis , Nielsen Torbjoern , Bulosan Hannah , Thorne Tyler J. , Ogasawara Christian T. , Birkeland Andrew C. , Tang Dennis M. , Wu Arthur W. , Steele Toby O. 
Published: September 2022

AbstractObjective/HypothesisTo investigate the clinical features, management strategies and outcomes for patients with metastatic primary skull base chordomas.Study DesignSystematic review.MethodsA systematic search through Pubmed/Medline, Web of Science, and EBSCOhost (CINAHL) was conducted without restriction on dates. After study screening and full‐text assessment, two authors independently extracted all data using a pre‐established abstraction form.ResultsForty cases were included from 38 studies. The average age (standard deviation [SD]) of the sample at presentation was 28.5 (23.3) and was equally distributed across genders. The average time (SD) between initial diagnosis to local recurrence was 40.1 (60.3) months. The average time (SD) from primary tumor detection to the diagnosis of metastatic disease was 55.2 (49.0) months. The most common subsite for metastatic spread were the lungs (32.5%). Of the 33 patients with data on outcomes, 48.5% were found to have expired by the time of publication. The median overall survival was estimated to be 84 months (95% confidence interval [CI] 62.3–105.7).ConclusionsThe most common subsites for metastatic spread of skull base chordoma were the lungs and bone. Overall survival for patients in the current cohort was a median of 84 months, with no significant differences noted when stratifying by the extent of surgery or the site of metastases.Level of Evidence3a
Kirigami‐Inspired Reconfigurable Thermal Mimetic Device
Authors: Wei Hang , Gu Jinxin , Ren Feifei , Geng Chenchen , Guan Huan , Liang Shuhui , Fan Qingpu , Zhao Jiupeng , Wang Chengyu , Dou Shuliang , Li Yao 
Published: September 2022

AbstractMimicry, a biological phenomenon whereby organisms can change their morphological characteristics to resemble another object, has stimulated the unprecedented development of devices that allow the manipulation of thermal emission. Herein, inspired by biological mimicry and the pattern evolution of Chinese Kirigami, this study demonstrates a universal and effective method to prepare devices that exhibit a reconfigurable and multilevel evolution of infrared (IR) thermal images based on vanadium dioxide (VO2). The significant discrepancy between the phase transition temperatures of VO2 with different tungsten doping fractions affords the reconfigurable response in thermal images to varying environmental temperatures. Particularly, the large degree of freedom afforded by evolution steps and local IR emissivity further consummates the thermal mimicry ability for diverse demands. Furthermore, the ultrafast response time, notable observation angle independence, and the active control system are also demonstrated. This study offers a new perspective for reconfigurable thermal mimetic devices and provides a new path for distinct applications such as IR communication, information encryption, and virtual/augmented reality.
Temporal Variation in Capture Efficiency Underrepresents Spring Out-Migrating Bull Trout in a Trap-and-Haul Program
Authors: Lewis Madeline C. , Guy Christopher S. , Oldenburg Eric W. , McMahon Thomas E. 
Published: September 2022

Abstract
Trap-and-haul programs can maintain connection among habitats for migratory salmonids in fragmented systems. To conserve diversity within and among life history strategies, downstream trap and transport of juvenile salmonids could ideally mimic the natural, underlying out-migration dynamics of the population. A two-way trap-and-haul program is implemented in the lower Clark Fork River, Montana, to conserve adfluvial Bull Trout Salvelinus confluentus. We used PIT technology to assess whether downstream trapping efforts are effectively capturing variation in the out-migration dynamics of juvenile Bull Trout in Graves Creek, a key spawning and rearing tributary in the system. We tagged 821 juvenile Bull Trout in Graves Creek and used these tagged Bull Trout in conjunction with stationary PIT antennas to monitor out-migration and evaluate efficiency of the downstream trapping program. Capture efficiency in Graves Creek varied substantially from autumn to spring, with 89–96% of autumn out-migrating Bull Trout captured and 5–10% of spring out-migrating Bull Trout captured. Overall, we found that Bull Trout transported during the autumn out-migration periods generally reflect the natural out-migration dynamics of the population; however, Bull Trout that out-migrate in the spring are currently underrepresented in the downstream transport program. By understanding the underlying out-migration dynamics of the Bull Trout population in Graves Creek, management of the downstream trapping efforts can focus on minimizing potential selection for or against out-migrants based on timing and age at out-migration. Minimizing selection will conserve variation within the adfluvial life history strategy and therefore maximize resilience of the adfluvial Bull Trout populations.
RNN‐EdgeQL: An auto‐scaling and placement approach for SFC
Authors: Pandey Suman , Choi Minji , Yoo Jae‐Hyoung , Hong James Won‐Ki 
Published: September 2022

SummaryThis paper proposes a prediction‐based scaling and placement of service function chains (SFCs) to improve service level agreement (SLA) and reduce operation cost. We used a variant of recurrent neural network (RNN) called gated recurrent unit (GRU) for resource demand prediction. Then, considering these predictions, we built an intuitive scale in/out algorithm. We also developed an algorithm that applies Q‐Learning on Edge computing environment (EdgeQL) to place these scaled‐out VNFs in appropriate locations. The integrated algorithm that combines prediction, scaling, and placement are called RNN‐EdgeQL. RNN‐EdgeQL (v2) is further improved to achieve application agnostic group level elasticity in the chain, independent of applications installed on the VNFs. We tested our algorithm on two realistic temporal dynamic load models including Internet traffic (Abilene) and an application specific traffic (Wiki) on an OpenStack testbed. The contribution of this article is threefold. First, prediction model prepares the target SFC for the upcoming load. Second, an application agnostic characteristics of the algorithm achieves the group‐level elasticity in SFC. Finally, the EdgeQL placement model minimizes the end‐to‐end path of an SFC in multi‐access edge computing (MEC) environment. As a result, RNN‐EdgeQL (v2) gives the lowest overall latency, lowest SLA violations, and lowest VNFs requirement, compared to RNN‐EdgeQL (v1) and Threshold‐Openstack default placement.
Physicochemical Characteristics and Growth Mechanisms of the Aluminosilicate Nanoparticles for Synthesis of Clinoptilolite
Authors: Bing Liujie , Sheng Mengdi , Sun Jihong , Zhai Chengwei , Bai Shiyang 
Published: September 2022

AbstractIn order to understand the growth behaviors of the aluminosilicate species in the initial hydrothermal process and thereafter synthesis of clinoptilolites with high purity, the physicochemical characteristics of the aluminosilicate nanoparticles were elucidated by small angle X‐ray scattering (SAXS) and X‐ray diffraction (XRD) patterns, scanning electron microscopy (SEM) images, Ultra‐Violet Raman (UV‐Raman) and Fourier transform infrared (FT‐IR) spectra. The results demonstrated that the aluminosilicate nanoparticles presented the first decreased surface fractal (Ds) values and then an increased Ds values in the initial reaction time of before 120 h. After that, the fractal transformations from Ds to mass fractal (Dm) occurred with the extensions of reaction time (120–144 h), but the decreased Dm values appeared after 144 h. Therefore, their growth mechanisms from uniform dispersions to aggregation, and even assembly were proposed.
Trinitro‐orcinolate and Trinitro‐resorcinate – Sensitivity Trends in Nitroaromatic Energetic Materials**
Authors: M. J. Endraß Simon , Neuer Andreas , Klapötke Thomas M. , Stierstorfer Jörg 
Published: September 2022

Abstract5‐Methyl‐2,4,6‐trinitrobenzene‐1,3‐diol (trinitro‐orcinol, H2TNO) as a close structural relative to the well‐known energetic materials trinitroresorcinol (styphnic acid) and trinitrotoluene (TNT) is prepared in high purity and analyzed concerning its vapor pressure using the transpiration method. Several energetic coordination compounds (ECCs) of its respective anion were produced and compared with structurally close styphnate complexes to give an insight into physiochemical trends of the ECC. The synthesized compounds were further analyzed by elemental analysis, IR spectroscopy, differential thermal analysis and low temperature X‐ray diffraction analysis. To classify the reported compounds among the energetic materials, they were tested for their sensitivities towards mechanical stimuli such as impact, friction and electrostatic discharge as well as their behavior towards flame.
Experiences of COVID‐19 pandemic‐related stress among sexual and gender minority emerging adult migrants in the United States
Authors: Alessi Edward J. , Cheung Shannon P. , Sarna Vincent , Dentato Michael P. , Eaton Andrew , Craig Shelley L. 
Published: September 2022

AbstractThere is a dearth of research that examines COVID‐19‐related stress among multiply marginalised individuals who are in the developmental phase of emerging adulthood. This qualitative study investigated how the intersection of emerging adulthood, sexual and gender minority (SGM) identity, and migrant status were reflected in the experiences of SGM individuals (n = 37; ages 20–25 years old) who migrated to various parts of the United States in the last 5 years. Data were collected online using semi‐structured interviews. Thematic analysis revealed that participants' developmental processes (e.g., identity exploration, building financial independence) were shaped by pandemic‐related stressors, especially unemployment and financial instability. Participants who were able to maintain employment did so but at the risk of their health and safety. Findings also showed that participants experienced feelings of anxiety and depression due to social isolation, but online communication played an important role in combatting loneliness. Findings highlight the potential for trauma‐informed and intersectional approaches to practice with SGM emerging adult migrants and expanded health services and temporary entitlement programs to mitigate the pandemic's effects on this population's psychosocial and financial well‐being.
Sunlight‐Controllable Biopharmaceutical Production for Remote Emergency Supply of Directly Injectable Therapeutic Proteins
Authors: Stefanov Bozhidar‐Adrian , Mansouri Maysam , Charpin‐El Hamri Ghislaine , Fussenegger Martin 
Published: September 2022

AbstractBiopharmaceutical manufacturing requires specialized facilities and a long‐range cold supply chain for the delivery of the therapeutics to patients. In order to produce biopharmaceuticals in locations lacking such infrastructure, a production process is designed that utilizes the trigger‐inducible release of large quantities of a stored therapeutic protein from engineered endocrine cells within minutes to generate a directly injectable saline solution of the protein. To illustrate the versatility of this approach, it is shown that not only insulin, but also glucagon‐like peptide 1 (GLP‐1), nanoluciferase (NLuc), and the model biopharmaceutical erythropoietin (EPO) can be trigger‐inducibly released, even when using biologically inactive insulin as a carrier. The facilitating beta cells are engineered with a controllable TRPV1‐mediated Ca2+ influx that induces the fusion of cytoplasmic storage vesicles with the membrane, leading to the release of the stored protein. When required, the growth medium is exchanged for saline solution, and the system is stimulated with the small molecule capsaicin, with a hand‐warming pack, or simply by using sunlight. Injection of insulin saline solution obtained in this way into a type‐1 diabetes mouse model results in the regulation of blood glucose levels. It is believed that this system will be readily adaptable to deliver various biopharmaceutical proteins at remote locations.