bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA‐200c overexpression in cancer‐associated fibroblasts decreases interleukin‐2 secretion
Authors: Shariati Laleh , Vaseghi Golnaz , Vaziri Nazanin , Shenavar Nasim , Zarrabi Ali , Haghjooy Javanmard Shaghayegh 
Published: June 2022

AbstractmiR‐200c‐3p is demonstrated to play the role of tumour suppressor in different tumours. However, the miR‐200c‐3p biological function in normal fibroblast (NF) and cancer‐associated fibroblast (CAF) remains unclear. This investigation aims to study the regulatory role of miR‐200c‐3p in the secretion of Interleukin‐2 (IL‐2) in CAF and NF. CAFs and NFs were isolated from tumour and normal tissue specimens respectively. Immunocytochemistry was used to confirm the presence of a fibroblast specific marker, alpha‐actin smooth muscle, in NFs and CAFs. NF and CAF were transfected with scramble and miR‐200c‐3p utilizing the lipofectamine 2000 reagent. The protein levels of IL‐2 were measured in CAFs, NFs, and transfected groups with miR‐200c‐3p and scrambled using an IL‐2 enzyme‐linked immunoassay kit. miR‐200c decreased secretion of IL‐2 in transfected CAF and NF compared to controls. Results elucidated that transfection of MiR‐200c‐3p can decrease the IL‐2 secretion and consequently reduce IL‐induced tumourigenic manner in the CAF.
Association between haemoglobin A1c and cerebral microbleeds in community‐based stroke‐free individuals: A cross‐sectional study
Authors: Yu Miaoxin , Jia Yanan , Yang Dandan , Zhang Runhua , Jiang Yong , Zhang Guitao , Qiao Huiyu , Han Hualu , Shen Rui , Ning Zihan , Zhao Xihai , Liu Gaifen , Wang Yongjun 
Published: June 2022

AbstractAimsThe association between haemoglobin A1c (HbA1c) and cerebral microbleeds (CMBs) remains unclear. We aimed to investigate the association between HbA1c and CMBs in community‐based individuals without stroke or transient ischaemic attack (TIA) and whether the association differs between individuals with and without diabetes mellitus (DM).Materials and MethodsAll individuals were recruited from a community in Beijing, China, from January 2015 to September 2019. All individuals completed a questionnaire and underwent blood tests and brain magnetic resonance imaging. A susceptibility‐weighted imaging sequence was acquired to detect CMBs, which were defined as small, round and low‐signal lesions with <10 mm diameter. The association between HbA1c and CMBs was analysed using multivariable logistic regression adjusted for demographics, medical history and blood sample test results. Subgroup analyses stratified by history of DM were performed.ResultsOf 544 recruited individuals, 119 (21.88%) had CMBs. HbA1c was independently associated with CMBs (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.03–2.22). In 87 individuals with DM, multivariable logistic analysis showed that HbA1c was significantly associated with CMBs (OR, 1.67; 95% CI, 1.04–2.69), whereas in individuals without DM, no significant association was observed between HbA1c and CMBs (OR, 1.07; 95% CI, 0.50–2.30).ConclusionsHbA1c was associated with CMBs in individuals without stroke or TIA, particularly in individuals with DM, suggesting that the status of glycaemic control warrants attention for the prevention of CMBs. It would be beneficial to manage HbA1c specifically to control the risk of CMBs, especially in individuals with DM.
Mining‐induced failure characteristics and surrounding rock control of gob‐side entry driving adjacent to filling working face in the deep coal mine
Authors: Chen Dongdong , Guo Fangfang , Xie Shengrong , Wang En , Wu Yiyi , Jiang Zaisheng , Wang Long , Cui Junqi , Zhang Xiao , Liu Ruipeng 
Published: June 2022

AbstractThis paper studies the width of narrow coal pillars, mining‐induced failure characteristics, and surrounding rock control effect of gob‐side entry driving (GED) adjacent to 2‐1208 filling working face with an approximately 900 m depth. Laboratory experiments, numerical simulations, loosening circle tests, and engineering practices are conducted. The mechanical properties of the filling body, the distribution and evolution law of the second invariant deviatoric stress (J2), and the variation in the plastic zone of the surrounding rock in GED are studied. The conditions of various coal pillar widths and the gob backfilled or not of the adjacent working face are also considered. The results of roadway driving along the filling working face in the deep coal mine are that: (1) The evolution law of J2 and the plastic zone features of the surrounding rock in GED have changed significantly. Thus, it is unreasonable to still adopt the customary theory of narrow coal pillar determination and roadway support design method of GED adjacent to nonfilling working face. (2) The plastic zone of GED has typically asymmetric distribution characteristics during driving and retreating, which is mainly concentrated at the upper corner of the virgin coal rib. And the elastic zone changes slightly by the influence of mining‐induced pressure on the working face, indicating that support in this area is easier. (3) During the stable period of roadway driving, there includes a “ring‐shaped” J2 depression zone at the upper corner of the coal pillar rib. While the peak zone distribution of J2 in the virgin coal rib of GED is approximately “crescent‐shaped,” and the peak zone is inclined to the upper corner of the virgin coal rib, which implies that this area is a crucial control region. (4) During the retreating period of panel 2‐1210, the direction of the maximum principal stress of GED gradually deflects from the direction of the gob to that perpendicular to the roof and floor, which represents that the key support area of GED has changed. Therefore, the advanced support of GED needs to be reinforced by single hydraulic props. The width of the coal pillar was determined to be 5 m, and a targeted truss anchor cable support method with bidirectional resistance function is proposed for the roof and both ribs, which realized the stability control of GED during deep filling mining.
Morphology and stratigraphy of aeolian sand stringers in southeast Minnesota and western Wisconsin, USA
Authors: Shandonay Kenzie L. , Bowen Mark W. , Larson Phillip H. , Running Garry L. , Rittenour Tammy , Mataitis Richard 
Published: June 2022

AbstractSand stringers are subtle, aeolian landforms that reach hundreds to thousands of metres in length and lack a slipface. While hundreds of sand stringers exist beyond the Last Glacial Maximum margin in the Upper Midwest, USA, little is known about the timing and nature of their formation. This research characterizes the morphology and stratigraphy and provides geochronological data from two sand stringers in the upper Mississippi River basin in Minnesota and Wisconsin.The sand stringers investigated have similar west–northwest to east–southeast orientations and are located ~100 km from each other on uplands west and east of the Mississippi River valley. The sand stringer in Goodhue County, Minnesota (GC site) is ~870 m long and 50–80 m wide. To the east, the sand stringer in Eau Claire County, Wisconsin (ECC site) is ~925 m long and 30–50 m wide. The main body of the GC sand stringer is characterized by an ~80–270 cm‐thick silt‐rich surface unit overlying a sandy unit that is underlain by a dark brown paleosol, while the main body of the ECC sand stringer is sandier/coarser, stratified, and overlies outwash.14C ages, interpreted as minima, at GC indicate formation began prior to 25–20 cal yr BP, while OSL and14C ages indicate ECC formed ~11.25–8.9 ka. We interpret the main body of GC as equivalent to Peoria Loess, with minor inputs of reworked outwash. We interpret ECC as composed of reworked outwash and local bedrock‐derived sands. Pedogenesis at GC and ECC indicates stabilization with possible minor modification of near‐surface sediments through the Holocene. Differences in stratigraphy and chronology between the two sites highlight the complexity of aeolian systems in the Upper Midwest, interpreted as indicative of the variety of sediment sources contributing to landform development via aeolian processes due to spatial and temporal variability in deglaciation and permafrost melting.
Enhanced reversible hydrogen storage efficiency of zirconium‐decorated biphenylene monolayer: A computational study
Authors: Mane Pratap , Kaur Surinder Pal , Chakraborty Brahmananda 
Published: June 2022

AbstractMetal decorated carbon‐containing two‐dimensional monolayers have been explored as potential hydrogen storage materials because of their open structures which improve the storage capacity. Here, the H2 storage capability of the Zr‐decorated biphenylene nanosheet is studied with the aid of first‐principles calculations. Biphenylene is a recently synthesized ultra‐flat material consisting of different‐sized carbon rings. Zr atom interacts strongly with the monolayer with a binding energy of −4.79 eV due to charge transfer from Zr 3d orbital to C‐2p orbital of biphenylene nanosheet. The hydrogen molecules bind to the Zr‐decorated biphenylene monolayer with an average adsorption energy of −0.4 eV per H2 due to Kubas‐type interactions involving charge transfer between metal d orbital and H‐1s orbital. The Zr decoration helps to adsorb up to 9 hydrogen molecules per metal atom on the monolayer resulting in the H2 uptake of 9.95 wt%, higher than the target of 6.5 wt% set by the Department of Energy (DoE), USA. The high diffusion barrier for the Zr atom prevents metal‐metal clustering. The ab initio molecular dynamics (AIMD) simulations show that the complexes remain stable even at the highest desorption temperature. The present study shows that the Zr‐decorated biphenylene can be considered a prospective two‐dimensional material for reversible hydrogen storage.
The flow of MHD Maxwell liquid over an extending surface with variable free stream temperature
Authors: Mandal Mani Shankar , Mukhopadhyay Swati 
Published: June 2022

AbstractThe aim of this article is to investigate the steady two‐dimensional flow of a magnetohydrodynamics Maxwell liquid over a stretched exterior having prescribed exterior hotness in the presence of changeable free stream temperature. Here the Maxwell liquid replica reflects non‐Newtonian liquid behavior. By means of similarity alterations, the leading differential equations which are partial in nature are altered to differential equations that are ordinary in nature and subsequently numerical solutions are received via a shooting scheme. The motion and heat transport characteristics for the leading parameters is scrutinized and talked about elaborately using their graphical demonstration. It is established that the liquid speed reduces with escalating magnetic parameter. The consequences of growing Maxwell parameter are to hold back the speed of liquid. An increment in heat movement speed has been observed for enhancing the temperature ratio and Maxwell parameters.
CoviDetNet: A new COVID‐19 diagnostic system based on deep features of chest x‐ray
Authors: Aslan Muzaffer 
Published: June 2022

AbstractCOVID‐19 has emerged as a global pandemic affecting the world, and its adverse effects on society still continue. So far, about 243.57 million people have been diagnosed with COVID‐19, of which about 4.94 million have died. In this study, a new model, called COVIDetNet, is proposed for automated COVID‐19 detection. A lightweight CNN architecture trained instead of the popular and pretrained convolution neural network (CNN) models such as VGG16, VGG19, AlexNet, ResNet50, ResNet100, and MobileNetV2 from scratch with chest x‐ray (CXR) images was designed. A new feature set was created by concatenating the features of all layers of the designed CNN architecture. Then, the most efficient features chosen among the features concatenating with the Relief feature selection algorithm were classified using the support vector machine (SVM) method. The experimental works were carried out on a public COVID‐19 CXR database. Experimental results demonstrated 99.24% accuracy, 99.60% specificity, 99.39% sensitivity, 99.04% precision, and an F1 score of 99.21%. Also, in comparison to AlexNet and VGG16 models, the deep feature extraction durations were reduced by approximately 6‐fold and 38‐fold, respectively. The COVIDetNet model provided a higher accuracy score than state‐of‐the‐art models when compared to multi‐class research studies. Overall, the proposed model will be beneficial for specialist medical staff to detect COVID‐19 cases, as it provides faster and higher accuracy than existing CXR‐based approaches.
Seasonality of prolactin in birds and mammals
Authors: Stewart Calum , Marshall Christopher J. 
Published: June 2022

AbstractIn most animals, annual rhythms in environmental cues and internal programs regulate seasonal physiology and behavior. Prolactin, an evolutionarily ancient hormone, serves as a molecular correlate of seasonal timing in most species. Prolactin is highly pleiotropic with a wide variety of well‐documented physiological effects; in a seasonal context prolactin is known to regulate annual changes in pelage and molt. While short‐term homeostatic variation of prolactin secretion is under the control of the hypothalamus, long‐term seasonal rhythms of prolactin are programmed by endogenous timers that reside in the pituitary gland. The molecular basis of these rhythms is generally understood to be melatonin dependent in mammals. Prolactin rhythmicity persists for several years in many species, in the absence of hypothalamic signaling. Such evidence in mammals has supported the hypothesis that seasonal rhythms in prolactin derive from an endogenous timer within the pituitary gland that is entrained by external photoperiod. In this review, we describe the conserved nature of prolactin signaling in birds and mammals and highlight its role in regulating multiple diverse physiological systems. The review will cover the current understanding of the molecular control of prolactin seasonality and propose a mechanism by which long‐term rhythms may be generated in amniotes.
Highly Bio‐Based Unsaturated Polyester Resins with Improved Performance by Incorporating Isosorbide into the Polyester Prepolymer
Authors: Li Yong , Qu Jiehao , Dai Zenghui , Jiang Junyi , Fu Jiajia , Fu Feiya , Liu Xiangdong 
Published: June 2022

AbstractHerein, the successful design of a highly bio‐based family of unsaturated polyester resins (UPRs) is presented, comprising of an isosorbide (ISO) incorporated unsaturated polyester prepolymer (UP) and a reactive diluent of 4‐vinylguaiacol acetyl ester (ACVG). A series of UPs are prepared by copolymerizing ISO with other green monomers, i.e., itaconic acid, ethylene glycol and oxalic acid, in a variation of ISO fraction. The UP/ACVG mixtures exhibit very low viscosity ranging from 2.8 to 3.7 Pa s. After curing at 135 °C to form a network, the resulting thermosets exhibit remarkable improvements in terms of glass transition (Tg, about 131 °C), storage modulus (2564–3342 MPa), and tensile strength (around 76.6 MPa), which are significantly better than the UP thermosets reported in previous works, The incorporation of ISO units into the UPs reveals a favorable effect on thermal stability of the thermosets as well. The best Td5% is measured to be 320.4 °C, and the volatile molecular information collected using a TGA‐GC/MS set suggests that the decomposition mechanism of the cross‐linked resins becomes heat‐resistant due to the ISO incorporation. Moreover, after being reinforced by cotton fabrics, an outstanding compatibility between the ISO containing UPRs and cotton fibers is found to be suitable for composite fabrication.
Tic Disorders, Anti‐Tic Medications, and Risk of Atopy
Authors: Hakimi Mathew , Skinner Sandra , Maurer Carine W. 
Published: June 2022

ABSTRACTObjectiveTo clarify patterns of comorbid atopic disorders in children with tic disorders compared to controls, and to evaluate whether medications commonly used for treatment of tics and attention deficit hyperactivity disorder (ADHD) are associated with differing risks of atopy.BackgroundInflammatory mechanisms are increasingly recognized as playing a role in a range of neuropsychiatric disorders. The association between tic disorders, ADHD, obsessive–compulsive disorder (OCD) and atopic disorders is uncertain.MethodsWe performed a retrospective cohort study using the global electronic health records database TriNetX. Using odds ratios, we compared the risk of atopy in children with tic disorder (n = 4508), ADHD (n = 83,569), and/or OCD (n = 1555) to controls (n = 758 290). To analyze the risk of developing atopy with use of different medications commonly prescribed to treat tics and ADHD, we performed a separate analysis including children with tic disorder, ADHD, and/or OCD who had initiated treatment with one of these medications. Binary logistic regression controlling for age and sex was used to calculate odds ratios.ResultsChildren with tic disorder, ADHD, or OCD were more likely than controls to have comorbid atopy. Children who had taken clonidine, guanfacine, methylphenidate, or dexmethylphenidate were more likely to develop an atopic disorder than controls.ConclusionsOur study suggests a link between atopic disorders and tic disorders, ADHD, and OCD. Although the underlying mechanism for this association remains unclear, medication use may play a role.
Test‐retest reliability of a new assessment to detect detailed temporal patterns of polysubstance use
Authors: Fitzgerald Nicole D. , Liu Yiyang , Wang Anna , Striley Catherine W. , Setlow Barry , Knackstedt Lori , Cottler Linda B. 
Published: June 2022

AbstractObjectiveWhile polysubstance use is highly prevalent among people who use drugs, the field lacks a reliable assessment that can detect detailed temporal patterns of polysubstance use. This study assessed the test‐retest reliability of the newly developed Polysubstance Use–Temporal Patterns Section (PSU‐TPS).MethodsParticipants who used cocaine plus alcohol and/or marijuana at least once in the past 30 days (n = 48) were interviewed at baseline and approximately 7 days later (retest) using the Substance Abuse Module and the PSU‐TPS. Reliability of PSU‐TPS measures of quantity, frequency, and duration of polysubstance use was examined using intra‐class correlation coefficients (ICCs) and kappa tests.ResultsExcellent reliability was observed for frequencies of concurrent polysubstance use patterns in the past 30 days (ICC range: 0.90–0.94) and quantity of alcohol use (ICC = 0.83), and fair to good reliability was observed for duration of substance use (ICC range: 0.52–0.73).ConclusionDetailed information regarding cocaine, alcohol, and marijuana polysubstance use in the past 30 days can be reliably measured with the PSU‐TPS. Data on the order and timing of polysubstance use at the hourly level will improve our understanding of the implications of sequential and simultaneous use patterns, which can help inform treatment and prevention efforts.
The Role of Adsorption‐Fenton Oxidation in Degradation of Phenolic Contaminants by Fabrication of Bionanocomposite from Industrial Residue
Authors: Lotfi Hoorie , Anbia Mansoor , Rahimi Rahmatollah , Yazdi Fatemeh 
Published: June 2022

AbstractPhenolic contaminants have acquired notable attention in recent years owing to their high toxicity even at low concentrations. This study reports the potential of cost‐effective activated carbon/chitosan/zero‐valent iron nanocomposite obtained from industrial waste residues on the adsorption and degradation of phenol, 2‐chlorophenol, and 2,4‐dichlorophenol from aqueous solution. The Fenton oxidation can supplement the pre‐adsorption process by altering to less hazardous compounds. The impact of initial concentration, contact time, nanocomposite dosage, pH, oxidant dosage, and temperature were monitored. The best matches among three adsorption isotherms Langmuir, Freundlich, and Harkins‐Jura were to Freundlich isotherm and the maximum adsorption capacity of phenol, 2‐chlorophenol and 2,4‐dichlorophenol reached 50.2512, 119.0476 and 114.9425
respectively. Furthermore, the activation energy, kinetic and thermodynamic parameters of Fenton‐oxidation were perused and affirmed that Fenton reactions are spontaneous with no energy barriers. The removal efficiency of phenol, 2‐chlorophenol, and 2,4‐dichlorophenol by synthesized nanocomposite was 97.7 %, 98.9 %, and 99 %, respectively.
A New Boron 2‐(2′‐pyridyl) Imidazole Complex as a Candidate Photosensitizer for Photodynamic Therapy
Authors: Ekmekci Zeynep , Eris Semanur 
Published: June 2022

AbstractIn this work, different from the literature, boron 2‐(2′‐pyridyl) imidazole complex (BOPIM) was derived from pyridine ring side to extend π conjugation for the first time. In addition, the core of BOPIM was brominated to increase the capacity of singlet oxygen generation via intersystem crossing to function as a photosensitizer. According to photophysical measurements, the new BOPIM derivative had comparatively large Stokes shift as 111 nm among boron–fluorine derivatives in the literature. Its singlet oxygen generation potential and toxic effect in the dark were investigated in the presence of singlet oxygen trap 1,3‐Diphenylisobenzofuran (DPBF). According to the obtained results, it was seen that the new BOPIM derivative could be a good photosensitizer for photodynamic therapy.
A Synthetic Overview of Enones Aziridination
Authors: Chandra Dinesh , Kumar Puneet , Yadav Ajay K. , Kumar Ganesh , Jat Jawahar L. 
Published: June 2022

AbstractAziridines are an important class of synthetic intermediates that are widely used in the synthesis of useful compounds and intermediates found in pharmaceuticals, natural products, and other functional materials. Several compounds with the aziridine ring system exhibit significant biological activity as well. Consequently, the synthesis of aziridines has been the focus of intense research over the last two decades. Despite numerous successful methods, no review article exclusively on Enone aziridination has been published to date. Therefore, the up‐to‐date developments in the synthesis of aziridines from enones, which are convenient synthetic precursors, by nucleophilic addition reactions are described with advantages, limitations, and mechanistic pathways.
Energetics and Spectroscopic Properties of Low‐lying CaC6H2 Isomers: An Astrochemical Perspective
Authors: Ghosh Avik , Banerjee Soumadip , Sarkar Subhendu , Debnath Tanay , Ash Tamalika , Roy Ria Sinha , Das Abhijit K. 
Published: June 2022

AbstractThe spectroscopic constants and molecular properties of low‐lying isomers of CaC6H2 have been studied using dispersion‐corrected density functional theory, MP2 and high‐level coupled‐cluster (CC) methods. 60 isomers have been identified, among which three low‐lying isomers having energy differences within 1 eV have been re‐optimized at MP2/cc‐pVTZ level. Isomer 1 (1‐calciacyclohepta‐4‐en‐2,6‐diyne) is found to be the most stable one, followed by isomer 3 (3‐calciahepta‐1,4,6‐triyne) and isomer 2 (1‐calciacyclohepta‐2,3,4‐trien‐6‐yne) that lie 20.9 and 19.7 kcal/mol above 1, respectively at MP2/cc‐pVTZ level. All three isomers are polar with a permanent electric dipole moment. Molecular properties like electron affinity, ionization potential as well as GCRD parameters, i. e., chemical potential, global hardness, etc. have been calculated at ae‐CCSD(T)/cc‐pVTZ level. NBO and AIM analyses have been performed to predict the nature of bonds in the isomers. The spectroscopic constants such as rotational and centrifugal distortion constants, inertial axis dipole moment components, etc. have been calculated using the frozen core (fc)‐CCSD(T) and all electron (ae)‐CCSD(T) methods with cc‐pVTZ basis. The ae‐CCSD(T) method with cc‐pwCVTZ‐X2C basis set has also been used to calculate spectroscopic constants. The predicted spectroscopic constants and molecular properties will facilitate in detecting these isomers in the laboratory as well as in interstellar medium (ISM).