bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-Scan Evaluation for the Detection of Benign Parapharyngeal Mass
Authors: Alim Md Abdul , Ahmed Rokshana , Haque Zerin , Islam Rafiqul , Jowarder Rownak Jahan , Rahman Meher Angez , Nahar Nazmun 
Published: February 2022

Background: Detection of benign parapharyngeal mass is very crucial for the management of the patients.
Objective: The purpose of the present study was to evaluate the CT scan for the detection of benign parapharyngeal mass.
Methodology: This cross-sectional study was carried out in the Department of Radiology and Imaging at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2009 to April 2011 for a period of around two years. All the clinically suspected cases of parapharyngeal space mass lesions attended in the Otolaryngology and Radiology & Imaging department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka were enrolled in this study. The patient in this study was evaluated according to the management plan for surgery followed in Otolaryngology department. The histopathology was performed by the histopathologist of the Department of Pathology at BSMMU, Dhaka, Bangladesh. All patients were undergone CT examination of neck and the comparison of the findings was done with the histopathology results.
Result: A total number of 50 patients were recruited for this study after fulfilling the inclusion and exclusion criteria. Mean (±SD) age of the patients was 37.76 (±14.82). Sensitivity of CT to diagnose benign parapharyngeal mass was 92.1%, specificity 83.3%, positive predictive value 94.6%, negative predictive value 76.9% and accuracy 90.0%. The area under the curve value was calculated and was found 0.142 (95% CI 0.000 to 0.286) (p=0.000).
Conclusion: In conclusion the sensitivity and specificity of CT scan for the detection of benign parapharyngeal mass lesion is very high.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 118-121
Efficacy and Safety of Tropical Use of Tranexamic Acid during Off-Pump Coronary Artery Bypass Surgery: A Randomized Control Trial
Authors: Hoque Asraful , Rubayath Tasmin , Rahman Romena , Hossain Md Tanvir , Saem Khan Abu Shadat Mohammad , Hossain Monzur , Ahsan Chowdhury Muhammad Asif , Ahmed Imran , Salam Wahida 
Published: February 2022

Background: Postoperative mediastinal bleeding in patients undergoing cardiac surgery is still one of the most common complications.
Objective: This study was intended to investigate the efficacy of topical tranexamic acid in reducing postoperative bleeding after post-operative cardiovascular surgery.
Methodology: In this non-randomized, double blinded, clinical trial, patients undergoing Off-Pump Coronary Artery Bypass (OPCAB) surgery in NICVD, Dhaka, Bangladesh during January 2014 to December 2015 and fulfilling inclusion and exclusion criteria were recruited. They were assigned in two groups- 30 patients in tranexamic acid group (Group 1) and 30 patients in placebo group (Group 2). On completion of the grafting, before closure of the sternum tranexamic acid (2.5 g/25 mL) or placebo (25 mL of saline) diluted in 100 mL of warm saline (370 C) was instilled into the pericardial cavity including the mediastinal tissues and left for 5 minutes. Then it was cleared out by wall sucker and sternum was closed.
Results: There was no significant difference in baseline demographic data, basic clinical characteristics and preoperative coagulation profile between the 2 groups (P > 0.05). Total mediastinal bleeding in group 1 and group 2 patients were421.67±70.32 vs 593.33±77.38ml, p<0.001. In case of, whole blood transfusion in group 1 and group 2 patients were 0.87±0.0.73 units and1.77±0.57 units respectively, p<0.001.
Conclusion: No patient required reoperation for bleeding and there was no incidence of prolonged ventilation, MI, thromboembolism, DVT or CVA in any of the patients in either group.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 142-146
Seroprevalence of Diphtheria IgG Antibody in Relation with Socio-demographic Change at a Tertiary Care Hospital in Bangladesh
Authors: Sajid Khandaker Md Tasnim , Das Premananda , Jahan Tarana , Sinha Shib Prasad , Prity Toufique Tania , Rahman Md Arifur , Khatun Siddika 
Published: February 2022

Background: Seroprevalance of diphtheria antibody may vary in different socioeconomic people.
Objective: The purpose of the present study was to determine the seroprevalence of diphtheria IgG antibody and to identify the relationship between diphtheria seroprevalence and several sociodemographic characteristics.
Methodology: This cross-sectional study was conducted in the Department of Microbiology at Sylhet MAG Osmani Medical College, Sylhet, Bangladesh from July 2016 to June 2017 for duration of one year. Apparently healthy individuals were enrolled in this study as study population by following a set of inclusion and exclusion criteria. For laboratory procedure, anti-diphtheria antibody titer was measured by ELISA method.
Result: A total number of 200 healthy individuals were recruited for this study. The mean serum IgG level was 0.23±0.26 IU/mL in participants of aged between 18 to 25 years which was much lesser in participants of aged between 26 to 32 years and 33 to 38 years group (p=0.001). Mean serum IgG level was 0.12±0.12 IU/mL in male participants. Majority participants have been come from lower middle class having mean serum IgG level of 0.10±0.21 IU/mL.
Conclusion: In conclusion diphtheria IgG level is most commonly found among young male adult person in upper middle class socioecomonic condition.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 156-160
Detection Capacity of Helicobacter pylori Infection by Stool Antigen Test Comparing with Rapid Urease Test among Peptic Ulcer Disease Patients
Authors: Samad Khurshida , Chowdhury Md Nazrul Islam , Ara Begum Kazi Nishat , Ahmed Imtiaz , Rupom Touhid Uddin , Saheduzzaman Md 
Published: February 2022

Background: Rapid urease test and stool antigen test are both important diagnostic tools for the detection of Helicobacter pylori infection among peptic ulcer disease patients.
Objective: The purpose of the present study was to compare the detection capacity of Helicobacter pylori infection with stool antigen test by comparing with rapid urease test among peptic ulcer disease patients.
Methodology: This cross-sectional study was conducted in the Department of Clinical Pathology with the collaboration of Department of Gastroenterology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from October 2011 to September 2012 for a period of one year. All the clinically suspected Helicobactor pylori infected peptic ulcer patients attending in the Department of Gastroenterology at Bangabandhu Sheikh Mujib Medical University (BSMMU) for upper GI endoscopy were selected as study population. Stool antigen test for Helicobactor pylori specific antigen from stool sample was done with “ABON-One Step Helicobactor pylori antigen test device”. Endoscopy of upper GIT was performed in the Department of Gastroenterology. Biopsy taken during endoscopy for RUT. Rapid urease test (RUT) of endoscopic biopsy was performed.
Result: A total 86 patients were recruited for this study. The mean (±SD) age was found 38.53(±10.40) years. Out of 86 patients 76 cases were SAT positive and 10 cases were negative. The sensitivity, specificity, positive predictive values and negative predictive values and accuracy of SAT with RUT are 85.53%, 90.0%, 98.48%, 45.0%, 86.05% respectively. The area under the curve was 0.283 with the lower and upper limits of 95% confidence interval of 0.133 and 0.432. This was statistically significant (p=0.003).
Conclusion: In conclusion the stool antigen test is an effective method for the diagnosis of Helicobacter pylori infection.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 161-164
Clinico-demographic Characteristics, Associated Anomalies and Treatment Profiles of Children presented with Undescended Testis at Medical University of Bangladesh
Authors: Alam Shoheli , Islam KM Didarul , Mahammad Noor , Dilshad Munmun Umme Habiba , Islam Md Nowfel 
Published: February 2022

Background: The most common paediatric disorder among boy is undescended testis (UDT) which is usually identified during birth and these patients require proper treatment at the appropriate time due to increased risk of torsion, infertility, testicular cancer and associated inguinal hernia(>90%) as well as for cosmetic purposes.
Objective: The purpose of this study was to determine side, palpability, age at presentation, associated anomalies and treatment plan in our institution.
Methodology: This retrospective study was carried out in the department of Paediatric Surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2017 to June 2019.
Results: In this study 1.08% (213 children had UDT out of total paediatric outdoor 19803 patients) boys had UDT. They were aged from 7 months to 15 years (mean 5.61±3.81 years) at presentation. Only 16 (7.5%) patients presented within the 1 years of age in this study. 51.8% of patients presented at the age of >1yrs-5yrs. > 5yrs-10yrs of age was 33.5% cases and 13.6% of patients presented as late as 10yrs to 15 yrs. Unilateral UDT was found in 184 (86.4%) patients and bilateral was in 29(13.6%) patients. Right- sided unilateral UDT was in 112(52.6%) patients, left -sided unilateral UDT was in 72 (33.8%) patients. Palpable testis was found in 178(83.6%) patients and non-palpable found in 35(16.4%) patients. Associated anomalies of UDT were seen in 64(30%) patients. Hypospaedias was in 19(08%) patients and intersex disorders were in 15 (07%) patients. Orchidopexy was done in 192(90.1%) cases and orchidectomy was done only in 4(1.9%) cases. No testis was found in17 (08%) cases.
Conclusion: UDT is one of the commonest disorders of paediatric age group. Very important issue is the early diagnosis and treatment of this anomaly. To treat the UDT in proper time help to optimize testicular function, earlier diagnosis of testicular malignancy, give cosmetic benefits and to prevent complications such as a clinical hernia or torsion.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 173-176
Prevalence and Resistance Profile of Acinetobacter baumannii Isolated from Clinical Specimens at a Tertiary Care Hospital in Bangladesh
Authors: Mahtab Uddin Bhuiyan Mohammad , Akhand Faria , Bari Sumia , Suchi Surovi Era , Saha Ritu , Ahmed Mejbah Uddin 
Published: February 2022

Background: Acinetobacter baumannii is one of the significant pathogens to cause healthcare-associated infections worldwide. It is difficult to control and the infections caused by it are difficult to treat, because it is multidrug resistant.
Objective: This study was conducted to determine the prevalence and antimicrobial resistance pattern of Acinetobacter baumannii at Dhaka Medical College Hospital, Dhaka, Bangladesh over a 12 months period.
Methodology: This retrospective study was carried out over a period of one year from July 2014 to June 2015 in the department of Microbiology at Dhaka Medical College Hospital, Dhaka, Bangladesh. Antimicrobial susceptibility testing of the isolates was performed by the disk diffusion method as recommended by Clinical Laboratory and Standards Institute CLSI.
Results: Non duplicate 28 A. baumannii were isolated out of a total 191 pathogenic Gram negative isolates (14.66% prevalence). The most frequently isolated A. baumannii was from ICU patients (75%) followed by inpatients (18%) and outpatients (7%). Most of the isolates were recovered from tracheal aspirates (75%). The resistance rates were higher than most of the internationally reported levels. Cephalosporins, aminoglycosides, fluoroquinolones and even carbapenems are becoming practically ineffective, where the colistin elicited the highest susceptibility levels.
Conclusion: This study has guided the empirical therapy and suggest that surveillance of antimicrobial resistance of Acinetobacter baumannii is necessary.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 177-180
First Few Cases of Intracranial Schwannoma treated with LINAC-based Stereotactic Radiosurgery in Bangladesh
Authors: Kumar Narendra , Yasmin Taohida , Appasamy Murugan , Ahsan Sania , Rana KM Masud , Das Sandip Kumar , Kumar R Arun , Rahman Zillur , Chanda Amitabha , Alam Md Shafiul 
Published: February 2022

Stereotactic Radiosurgery has been widely utilized for the treatment of intracranial lesions, and this paper presents our experience in treating schwannomas in Bangladesh. This case series was described to present our institutional experience and procedural technique adapted for treating intracranial schwannomas using stereotactic Radiosurgery (SRS) by Linear accelerators. This case series since starting our radiosurgery program in March 2019, we have treated three patients of intracranial schwannoma. Two patients had vestibular schwannoma, and one had Trigeminal Schwannoma. All three patients first underwent surgical intervention and on recurrence/progression treated with stereotactic Radiosurgery. Tumor volume ranged from 4.47 to 10.22 cm3. The dose prescription ranges from 13 to 14Gy in one or two fractions, which was subject to tumor volume, its proximity to a critical structure, existing neurologic deficit, and optimal balance between prescribed dose and predicted complications. All three procedure was free of any immediate adverse event. LINAC based Stereotactic Radiosurgery was found to be a safe and effective option for the treatment of schwannomas. All three patients have a very good clinical outcome, and one patient who has more than one-year post-SRS revealed a significant regression in the size of the tumor.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 181-189
Comparative analysis of the hemostasis system of cancer patients with thrombotic complications
Authors: Bodnar P. Ya. 
Published: February 2022

Surgical treatment of female genital cancer remains a rather difficult task in gynecological practice due to the possibility of thrombotic complications. It is important to study the features of hemostasis in such patients for the practical application of this knowledge. The aim of the study was to scientifically substantiate the features of hemostasis in patients with female genital cancer. Study materials: 103 patients with genital cancer who were treated.
The purpose of the study. Coagulogram, colorimetry, others. Results of the research. As a result of a blood test, it was found that the initial level of hemoglobin in patients with thrombotic complications after surgery decreased by 12%, in patients without thrombotic complications – by 14%. The average platelet count in patients with thrombotic complications decreased by 11,50%, in patients without thrombotic complications – 8,12%. The level of leukocytes in patients with thrombotic complications – increased by 21,05%, in patients without thrombotic complications – 30,30%. In the study of hemostasis, it has been found that surgery in patients with female genital cancer causes a pronounced activation of the hemostasis system, especially in patients with thrombotic complications. In patients with thrombotic complications there is a more pronounced activation of intravascular coagulation on the background of a significant decrease in the level of antigen III than in patients without thrombotic complications. The level of fibrinogen in patients with thrombotic complications in the preoperative period was significantly higher by 16,3% than in patients without thrombotic complications; there was a decrease in fibrinogen levels in the early postoperative period; from the third day after surgery, fibrinogen levels increased in patients without thrombotic complications. There was also a significant reduction in activated partial thromboplastin time in patients with thrombotic complications. The number of soluble complexes of fibrin monomers increased to higher values in patients with thrombotic complications. Conclusion. In the study of hemostasis, it has been found that surgery in patients with female genital cancer causes marked activation of the hemostasis system, especially in patients with thrombotic complications.
Cognitive disorders in patients with nervous system injuries by persistent degrees
Authors: Muravska L. V. , Andreeva O. G. , Dyachenko P. A. , Vasilik V. S. , Klyus V. Yu. 
Published: February 2022

Purpose of the study. To study the severity of CP in patients with lesions of the nervous system by persistent pathogens.
Materials and methods of research. Clinicalneurological and neuropsychological research. 53 patients were examined, including 42 (72,24%) women and 11 (20,75%) men. Among them, 32 (60,37%) patients with herpesvirus lesions of the nervous system and tickborne borreliosis (chronic form) – 21 (39,62%). Age of patients – from 19 to 64 years. The control group consisted of 30 people who had no history of herpesvirus lesions of the nervous system and tickborne borreliosis aged 20 to 60 years. According to the involvement of the central and peripheral nervous system in the pathological process, the clinical diagnoses were as follows: arachnoencephalitis, encephalitis, meningoencephalitis in 22 patients (41,5%), arachnoiditis 12 (22.64%), encephalomyelitis 1 (1,88%), diffuse encephalomyelitis 6 (11,32%), arachnoencephalomyelopolyneuropathy 3 (5,66%), encephalopolyneuropathy 5 (9,43%).
New approaches to basic treatment of asthma
Authors: Fushtey I. M. , Savchenko O. A. , Podsevahyna S. L. , Tkachenko A. V. , Myrnyi D. P. , Katsuba J. V. 
Published: February 2022

Among chronic respiratory diseases, asthma is one of the most common diseases. The current goal of asthma treatment is to achieve asthmacontrol. Despite the fact that, according to the data of randomized trials, this goal is achievable in most patients, in real clinical practice the proportion of patients who have achieved asthmacontrol does not exceed 42–49%. The article provides an analysis of these recommendations and a literature review of those studies that justify their changes. A key change in the new GINA recommendations is the rejection of shortacting beta2agonists as monotherapy in patients with mild stage I asthma.
The priority regimen of basic therapy at this stage of treatment is now a fixed combination of budesonide/formoterol, taken on demand. Such therapy, according to the literature, was significantlymoreeffectivethanshortactingbeta2 agonists monotherapy. In addition, budesonide/ formoterol is also considered as a priority drug for relieving symptoms on demand, and short acting beta2agonists is currently classified as an alternative drug.
The recommendation is based on the data of randomized trials, in which it was proved that the use of a fixed combination of budesonide/ formoterol on demand, significantly reduces the number of exacerbations of asthma compared with the use of shortacting beta2agonists on demand. The introduction of new GINA recommendations into practice will improve the effectiveness of basic therapy for asthma.
The content of the total protein, protein fractions and blood serum proteins in patients with different forms of lichen ruber planus
Authors: Barannik N. G. , Tsymbaliuk R. Y. , Manukhina O. M. , Sydoryako A. V. , Volchykhina K. P. 
Published: February 2022

Purpose of the study. Establishing the role of processes of proteolysis of mixed saliva in the development and course of lichen planus of the oral mucosa.
Materials and methods. A comprehensive examination of 102 patients with lichen planus aged 21 to 70 years and 20 people in the control group, whose age and sex composition corresponded to that in the study group. BioRad (USA) reagent kits were used to determine the total protein content of mixed saliva. The content of protein fractions of mixed saliva was determined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. Determination of serum proteins in mixed saliva was performed by quantitative (cross) immunoelectrophoresis.
Results. In patients with lichen planus, the overall proteolytic activity of mixed saliva increases with a significant increase in the concentration of α1proteinase inhibitor, especially in exudative hyperemic and erosiveulcerative forms of the disease. Diffusion of α1proteinase inhibitor into mixed saliva increases its antiproteolytic potential and has a protective character. The content of albumin and ceruloplasmin in the mixed saliva of patients with lichen planus increases depending on the severity of the disease: typical, hyperkeratotic, exudativehyperemic, erosiveulcerative.
Conclusions. Mixed saliva of patients with lichen planus in contrast to patients in the control group is characterized by the predominance of low molecular weight proteins (20–79 kDa) over high molecular weight. The level of albumin, α1proteinase inhibitor and ceruloplasmin in the mixed saliva of patients with lichen planus increases and correlates with the severity of the disease. The content of IgA in the mixed saliva of patients with lichen planus increases, depending on the form of the disease.
Psychopersonal characteristics of women with varying degrees of menopausal disorders
Authors: Lutsenko N. S. , Mazur O. D. , Shapoval O. S. , Zvarich L. I. , Efimenko N. F. 
Published: February 2022

The perimenopausal period is the age of the highest spiritual and intellectual development of a woman; therefore, neurovegetative and psycho-emotional disorders of this period acquire a pecial medical and social value and require an interdisciplinary approach.
Purpose of the study. To identify the psychological characteristics of women with mild and moderate menopausal disorders in the perimenopausal period.
Materials and methods. A total of 51 women were examined in the perimenopausal period: I main group – 20 patients with a low degree of CS, II main group – 16 women with menopausal disorders of moderate severity; the control group consisted of 15 healthy women. The severity of menopausal syndrome was determined using a modified menopausal Cooperman's index. All patients underwent psychodiagnostic examination using reactive and personal anxiety scales according to Ch.D. Spielberg and J.L. Hanina, G. Eisenko's test questionnaire, the Women's Sexual Function Index (FSFI) questionnaire, used the SF-36 (Medical Outcomes Study Short Form) general questionnaire to assess quality of life.
Results. In women of the main groups, neurovegetative (14,5 ± 2,6 and 26,6 ± 4,2 points in the first and second groups of observation) and psycho-emotional disorders (4,9 ± 1,3 and 11,2 ± 1,6 points) prevailed. respectively). Hormone levels (FSH, E2, PRL) corresponded to perimenopausal values, but were significantly different from those of the control group. Identified individual-personal properties of women with the CS, in particular introversion and emotional instability. A comparative analysis on the SpielbergKhanin scales showed that more than half (55,0%) in the first main group and the majority (81,25%) of women in the second main group versus 33,35% in the control group (p ˂ 0,05), a high level of personal anxiety was diagnosed; the average level of situational anxiety was highest among women in group II – 54,83 ± 6,0 points versus 43,2 ± 5,3 points in the first group and 36,3 ± 4,8 points in patients without menopausal disorders (p ˂ 0,05). In 24 (77,42%) women of the main group, sexual dysfunction was detected, while its degree was greatest with moderately severe climacteric disorders. Menopausal disorders of varying severity, increased anxiety and neuroticism, sexual dysfunction affected the quality of life of patients.
Conclusion. Formed psychopersonal characteristics of women with varying degrees of menopausal disorders in the perimenopausal period.