bluuebunny/crossref_metadata_2025_split huggingface dataset:
CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature ofKRASandNRASmutant cancers
Authors: Basu Srikanta , Luke Brian T. , Karim Baktiar , Martin Nancy , Lockett Stephen , Das Sudipto , Andresson Thorkell , Saylor Karen , Kozlov Serguei , Bassel Laura , Esposito Dominic , Galloux Mélissa , Johnson Peter F. 
Published: April 2022

AbstractOncogenic RAS induces perinuclear translocation of the effector kinases ERK and CK2 and their scaffold, KSR1, forming endosomal signaling hubs termed perinuclear signaling centers (PSCs). PSCs are present in all cancer cell lines and tissues examined, suggesting that subcellular compartmentalization of oncogenic kinases drives tumorigenesis. However, the mechanism of perinuclear targeting, whether this location affects kinase substrate specificity, and the importance of PSCs in cancer are unclear. Here we show that the endosomal adaptor, TOLLIP, specifically tethers RAB11A+signaling endosomes containing CK2 and KSR1 to the perinuclear ER. A predicted β-hairpin fold in TOLLIP mediates binding to the KSR1 CA5 pseudo-kinase domain, recruiting CK2/KSR1 complexes to perinuclear endosomes. TOLLIP is essential for proliferation/survival of tumor cells carryingKRASandNRASmutations but notHRAS,BRAF,ERBBorPTENlesions, or non-transformed cells.KRasG12D-induced lung lesions inTollip-/-mice displayed reduced numbers of carcinomatous lesions, implicating TOLLIP in malignant progression. TOLLIP-dependent perinuclear CK2 was shown to phosphorylate discrete substrates, including proteins involved in translation and ribosome biogenesis such as RIOK1. Thus, TOLLIP is a key RAS pathway signaling adaptor inK/NRAStumors whose inhibition is a specific vulnerability of these cancers.
Bumblebees retrieve only the ordinal ranking of foraging options when comparing memories obtained in distinct settings
Authors: Solvi Cwyn , Zhou Yonghe , Roper Mark , Feng Yunxiao , Sun Li , Reid Rebecca , Chittka Lars , Barron Andrew , Peng Fei 
Published: April 2022

AbstractAre animals’ preferences determined by absolute memories for options (e.g., reward sizes) or by their remembered ranking (better/worse)? The only studies examining this question suggest humans and starlings utilize memories for both absolute and relative information. We show that bumblebees make decisions using only memories of ordinal comparisons. After learning to discriminate pairs of different flowers by sucrose concentration, bumblebees preferred flowers (in novel pairings) with 1) higher ranking over equal absolute reward, 2) higher ranking over higher absolute reward, and 3) identical qualitative ranking but different quantitative ranking equally. Despite these suboptimal choices, bumblebees found the optimal option in an ecologically relevant foraging task. Our results illuminate a divergent mechanism of learned preferences that may have arisen from adaptations to bumblebees’ natural environment.
m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site
Authors: Parker Matthew T , Soanes Beth K , Kusakina Jelena , Larrieu Antoine , Knop Katarzyna , Joy Nisha , Breidenbach Friedrich , Sherwood Anna V , Barton Geoffrey J , Fica Sebastian M , Davies Brendan , Simpson Gordon G 
Published: April 2022

AbstractAlternative splicing of messenger RNAs is associated with the evolution of developmentally complex eukaryotes. Splicing is mediated by the spliceosome, and docking of the pre-mRNA 5’ splice site into the spliceosome active site depends upon pairing with the conserved ACAGA sequence of U6 snRNA. In some species, including humans, the central adenosine of the ACAGA box is modified by N6 methylation, but the role of this m6A modification is poorly understood. Here we show that m6A modified U6 snRNA determines the accuracy and efficiency of splicing. We reveal that the conserved methyltransferase, FIO1, is required for Arabidopsis U6 snRNA m6A modification. Arabidopsis fio1 mutants show disrupted patterns of splicing that can be explained by the sequence composition of 5’ splice sites and cooperative roles for U5 and U6 snRNA in splice site selection. U6 snRNA m6A influences 3’ splice site usage and reinforces splicing fidelity at elevated temperature. We generalise these findings to reveal two major classes of 5’ splice site in diverse eukaryotes, which display anti-correlated interaction potential with U5 snRNA loop 1 and the U6 snRNA ACAGA box. We conclude that U6 snRNA m6A modification contributes to the selection of degenerate 5’ splice sites crucial to alternative splicing.
Comparative analysis of the structure of complete chloroplast genomes in genus Mangifera and accuracy verification about phylogenetic analysis based on gene ycf2 in genus level
Authors: Tang Yujuan , Luo Shixing , Zhang Yu , Zhao Ying , Li Riwang , Guo Limei , Huang Guodi , Gao Aiping , Huang Jianfeng 
Published: April 2022

AbstractMango is an evergreen plant belonging to the genus Mangifera of the Anacardiaceae family. Genus Mangifera has 69 species of Mangifera around the world that are mainly distributed in tropical and subtropical countries, including India, Indonesia, the Malay Peninsula, Thailand, and South China. It is a popular tropical fruit known as the “King of Tropical Fruits”. However, the study of the structure information of the complete chloroplast genome of Mangifera was microscopic, there was no report about the comparison of SSR, Ka/Ks, codons analysis and RNA editing, so in this study, we sequenced the 6 Mangifera samples and used three different ways to analyze the relationship of 6 species of Mangifera. Then we got some results, through the RNA editing and Ka/Ks calculating, we found the species could be divided into two groups, and the difference between the two groups was protein-coding gene ccsA. Moreover, all RNA editing occurred conversion of C to T and the gene ndhB had the most RNA editing sites in all species. In Ka/Ks analysis, the gene atpB, cemA, clpP, ndhD, petD, petB and ycf15 would be suffered from the positive selection after divergence. We also find the IR regions in these seven samples were very conservation through IR contraction and expansion and Sequence Divergence Analysis. Finally, we tried to confirm the relationship between 7 samples of Mangifera in Angiosperms in 3 different ways. Then we got that ML210 and MP090 had a closer relationship than others, MS796 had a closer relationship with ML210 and MP090 than others. At the same time, the method of phylogenetic analysis based on the gene ycf2 was not more accurate at the genus level than the method based on complete cp genome and proteincoding genes.
A DEA-based comprehensive benchmarking approach for implementing continuous improvement
Authors: Yu Peng , Yoo Bok Young , Lee Jang Hee 
Published: April 2022

PurposeThe purpose of this study is to propose a comprehensive benchmarking approach to help subsidiaries of a company to implement continuous improvement (CI).Design/methodology/approachThe proposed approach classifies subsidiaries of a company into the three stages of CI. After that, the proposed approach employs data envelopment analysis (DEA)-super slacks-based measure (SBM) model and Malmquist Productivity Index (MPI) to evaluate the operational efficiency of the subsidiaries and selects benchmarking targets and sets benchmarking goals based on the operational efficiency for benchmarking of input and output criteria. Then, the proposed approach suggests a four-step benchmarking process for benchmarking of detailed efficiency. Finally, the proposed approach makes the subsidiaries achieve CI by implementing the input and output benchmarking and the efficiency benchmarking.FindingsThe results show that the proposed approach can help subsidiaries of a company to implement a staged benchmarking which considers input and output criteria and Malmquist productivity and efficiency comprehensively.Originality/valueGenerally, benchmarking is implemented in many aspects. However, due to the restriction of a company’s resource level, a practical and staged benchmarking is preferred. This study proposes a comprehensive approach to benchmark systematically and gradually, and provides a more reasonable benchmarking process for implementing CI.
A systematic review of the knowledge domain of institutional theory in construction project management
Authors: Qiu Yumin , Chen Hongquan 
Published: April 2022

PurposeThe large scale of construction projects and the coexistence of multiple logics in the construction field are sparking interest in applying an institutional perspective to investigate managerial issues in construction projects. However, only a few conceptual papers have been published thus far, and a literature review is needed to identify how that knowledge domain has developed. Based on the results of bibliometric analysis and content analysis, this study proposes potential future avenues for institutional theory in construction project management (ITCPM) studies.Design/methodology/approachThis paper reports a bibliographic coupling analysis and a co-citation analysis conducted to identify existing research trajectories and determine the primary features of the current ITCPM literature. In addition, this paper employed a content analysis, identified the evolutionary stages of ITCPM knowledge over time and built a framework of existing research.FindingsThis paper first identified that the existing ITCPM studies evolve through three stages, and that the intellectual core of ITCPM studies can be categorized into five clusters. In addition, this paper proposes that future research can be extended from two existing streams: the institutional responses of project actors and the institutional outcomes of construction projects. This paper proposes several major questions that should be addressed by project management scholars working in both streams in order to develop an understanding of construction projects from an institutional perspective.Originality/valueThis is the first literature review of the existing body of knowledge based on a joining of institutional theory and construction project management literature. It uncovers knowledge gaps in contemporary research, notably a lack of broader consideration of how project actors respond to institutional environments and of the institutional outcomes of project management.
Employee-oriented human resource policy as a factor shaping the influence of servant leadership on job performance
Authors: Ludwikowska Kamila 
Published: April 2022

PurposeAlthough there is growing research on the relationship between servant leadership and job performance, limited research examined conditions under which servant leadership is more effective. The purpose of this paper is to investigate whether employee-oriented human resource policy is shaping the relation between servant leadership and job performance.Design/methodology/approachEmpirical research was carried out among 263 organizations operating in Poland. To verify formulated hypotheses, statistical reasoning with moderator was made using model 1 of SPSS Macro Process.FindingsThe present study has proved that employee-oriented human resource policy may act as a moderator between servant leadership and job performance strengthening this relation. Integrating human resource policy with leadership is important to reach a better understanding of how human resource and leadership can influence employee performance.Originality/valueThe current study provides a practical implication for organizations to train managers with leadership skills to improve the job performance of their employees.
The impact of luxury brand status signaling, extension authenticity and fit on luxury line extension evaluation: a cross-national study
Authors: Boisvert Jean , Ashill Nicholas J. 
Published: April 2022

PurposeGrounded in categorization theory, this study examines the impact of luxury parent brand status signaling on brand extension authenticity and consumer attitudes in two international luxury markets.Design/methodology/approachUsing samples of luxury consumers from France and the United States, the study's hypotheses are tested using confirmatory factor analysis (CFA), structural equation modelling (SEM) and multi-groups comparisons.FindingsFindings demonstrate that luxury parent brand (PB) status signaling, familiarity and perceived quality impact luxury extension authenticity, and authenticity has a significant effect on consumer attitudes toward the extension. The relationship between PB status signaling and extension authenticity is stronger for French consumers compared to their American counterparts. The effect of luxury PB perceived quality and familiarity on PB status signaling is similar for both American and French consumers. However, the effect of PB familiarity on luxury brand extension authenticity is stronger in France than the United States.Research limitations/implicationsResults provide researchers and managers with insights on how to design marketing programs for luxury line extensions in a cross-national context.Originality/valueThe authors contribute to existing literature examining factors related to the parent brand and the relationship between the parent brand and the extension by examining the effect of PB status signaling and extension authenticity on extension attitudes in two international luxury markets.
Artificial intelligence in customer relationship management: literature review and future research directions
Authors: Ledro Cristina , Nosella Anna , Vinelli Andrea 
Published: April 2022

PurposeDue to the recent development of Big Data and artificial intelligence (AI) technology solutions in customer relationship management (CRM), this paper provides a systematic overview of the field, thus unveiling gaps and providing promising paths for future research.Design/methodology/approachA total of 212 peer-reviewed articles published between 1989 and 2020 were extracted from the Scopus database, and 2 bibliometric techniques were used: bibliographic coupling and keywords’ co-occurrence.FindingsOutcomes of the bibliometric analysis enabled the authors to identify three main subfields of the AI literature within the CRM domain (Big Data and CRM as a database, AI and machine learning techniques applied to CRM activities and strategic management of AI–CRM integrations) and capture promising paths for future development for each of these subfields. This study also develops a three-step conceptual model for AI implementation in CRM, which can support, on one hand, scholars in further deepening the knowledge in this field and, on the other hand, managers in planning an appropriate and coherent strategy.Originality/valueTo the best of the authors’ knowledge, this study is the first to systematise and discuss the literature regarding the relationship between AI and CRM based on bibliometric analysis. Thus, both academics and practitioners can benefit from the study, as it unveils recent important directions in CRM management research and practices.
Whistleblowing: procedural and dogmatic problems in the implementation of directive (EU) 2019/1937
Authors: Teichmann Fabian Maximilian , Wittmann Chiara 
Published: April 2022

Purpose
This paper aims to enlighten the shortcomings of the EU Whistleblowing Directive 2019/1973, which could interfere negatively with its successful national implementation. In focus is the tension between companies potentially attempting to hide misconduct and disgruntled employees taking advantage of generous protection under the directive.

Design/methodology/approach
With an extensive literary basis, this paper explores articles of the EU Whistleblowing Directive 2019/1973 under five areas of the so-called “weakness.” With view to Germany and Austria, the difficulty of implementing the directive is highlighted and likewise with view to Switzerland, a potential solution is presented.

Findings
The Whistleblowing Directive 2019/1973 overshoots its target by protecting whistleblowers without considering the wider public interest. There are specific points of arbitrary definition which demand resolution to ensure a successful national implementation.

Originality/value
This is a multifaceted discussion of a highly contentious ethical debate. Through an exploration of specific points of the Directive, it is possible to present why there are points of contention in the first place, and also the difficulty of implementing the principle of proportionality. The issue at the heart of the matter is balancing the protection of trade secrets with the fundamental necessity of whistleblowing as a means of last resort.
Probiotic supplement as an adjunctive therapy with Ritalin for treatment of attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled randomized clinical trial
Authors: Ghanaatgar Milad , Taherzadeh Sina , Ariyanfar Shadi , Razeghi Jahromi Soodeh , Martami Fahime , Mahmoudi Gharaei Javad , Teimourpour Amir , Shahrivar Zahra 
Published: April 2022

Purpose
Accumulating evidence highlights the importance of microbiota-directed intervention in neuropsychiatric disorders. This study aims to investigate the effects of probiotic supplements as an adjunct therapy in combination with Ritalin in children with attention-deficit hyperactivity disorder (ADHD).

Design/methodology/approach
Children with ADHD, aged 6–12 years, who had an intelligent quotient of ≥70 were enrolled in the study. Participants were randomly assigned to either the group that received probiotics or the group that received the placebo in addition to the weight-adjusted dose of Ritalin. Parents were asked to complete the revised Conners Parent Rating Scale–short version (CPRS–RS), and the psychiatrist completed the seven-point Clinical Global Impression–Severity (CGI–S) scale. Two study groups were compared in three time points, including T1 (before intervention), T2 (at the end of fourth week) and T3 (at the end of the eighth week).

Findings
A total of 38 participants completed the study. After eight weeks of intervention, the probiotic group had a significant improvement regarding CPRS–RS scores in T2 (9.4 unit, p = 0.014) and T3 (18.6 unit, p < 0.001), compared to placebo. In addition, children in the probiotic group had 0.7 unit lower CGI in T3 (p = 0.018) than the placebo group. A significant reduction of CGI scores was observed in each interval (T2 vs T1, T3 vs T2 and T3 vs T1; p < 0.05). This significant change in CGI score between intervals was also detected in the placebo group in T2 vs T1 (p = 0.002) and T3 vs T1 (p < 0.001). Mean CPRS scores of the groups were different in T2 and T3 (p = 0.011 and p < 0.001, respectively) and mean CGI scores of the two study groups were different in T3 (p = 0.018).

Originality/value
Eight weeks of supplementation with probiotics had a favorable effect on symptoms and severity of ADHD. Therefore, probiotics as an adjuvant treatment might have a promising efficacy regarding the management of ADHD.
Applying bounded rationality to information disposition: development of a risk/reward heuristic
Authors: Barragan Salvador P. 
Published: April 2022

Purpose
This paper aims to examine the implications of applying Herbert Simon’s bounded rationality to records and information management (RIM) and the possibility that a risk/reward heuristic may be part of the disposition decision-making cognitive process. This in turn may improve the understanding of disposition and its suboptimal results and offer alternatives in understanding why certain behaviors exist around keeping information beyond its retention; and to possibly alter this behavior. This in turn may improve the application of information life-cycle policies through the development of new decision-making heuristics for information retention.

Design/methodology/approach
This paper examines disposition of information and how the addition of bounded rationality may improve the understanding of why disposition has not been as successful as it might be.

Findings
This paper concludes that bounded rationality could elevate the RIM function and alter how RIM practitioners within the private sector understand how appraisal and therefore disposition of information occurs. Further, the inclusion of bounded rationality into disposition decision-making may create new roles for practitioners and extend the influence and reach of RIM. Future developments must be watched and analyzed to see if this approach becomes the norm.

Practical implications
This paper will be of interest to stakeholders responsible for valuing information, appraisal/disposition of information, life-cycle management, records management, information management and big data analytics. The work is original, but parts of this subject were previously addressed in another study.

Originality/value
Parts of this work were part of a PhD study by this author.
Broadcasting, through TV, social services information to older persons
Authors: Silva Telmo 
Published: April 2022

Purpose
The purpose of this paper is to depict the field trial to evaluate the usability and usefulness of an Interactive TV platform that aims to promote the info-inclusion and quality of life of Portuguese older adults by delivering informative content about public and social services.

Design/methodology/approach
The present paper reports the process of a field trial conducted to test an iTV platform’s usability and user experience along with 21 senior users. A high-fidelity prototype was tested with potential users for two weeks to collect data in a “real life” background to gather valuable information to refine the solution according to the target public needs.

Findings
The results revealed positive usability levels and overall satisfaction of the users in interacting with the system, yet not stopping them from giving their inputs and feedback. The informative videos sent to the platform were considered adequate, the remote control was simple and caused no problems, the video library and the splash screen were both positively reviewed.

Originality/value
This original research offers insights on how valuable is making field trial in the development of an innovative technology regarding this target population. Also, it was possible to understand that older adults want to be informed. Despite this, most of the time, they are unable to find the information efficiently. These results also supported the usefulness of the +TV4E platform.
To spend or to save? The role of time perspective in the saving behavior of children
Authors: Trzcińska Agata , Sekścińska Katarzyna , Maison Dominika 
Published: April 2022

Purpose
This study aims to focus on the possibility of promoting saving behaviors in children by activating a future time perspective (TP) in their thinking.

Design/methodology/approach
An experimental study of 8- to 11-year-old children (N = 212) was conducted in which future and present hedonistic TPs were induced.

Findings
The results suggest that inducing a future TP can modify children’s financial behavior, making them more inclined to save their money. However, the induction of a present hedonistic TP had no significant effect on children’s financial decisions.

Originality/value
This study improves current theoretical knowledge concerning the effectiveness of psychological interventions in fostering saving behaviors in children and answers the question posed of how the economically desirable behavior of saving may be enhanced in children. Thus, inducing a future TP in children by showing them the benefits of focusing on the future might constitute a useful means of strengthening children’s saving abilities.