bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Properties and Slope Inventory of Clayey Soil from the Trusmadi Formation in Bundu Tuhan, Sabah
Authors: Ayu Sufiah Khairul Nur , Musta Baba 
Published: March 2022

Abstract
The study area in Bundu Tuhan mainly consists of the metasedimentary rock of the Trusmadi Formation. Trusmadi Formation aged Palaeocene to Middle Eocene made up of interbedded dark grey shale and thin sandstone that shows the characteristics of deep marine sediment. Shale bed also known as phyllite unit is the major rock unit in Trusmadi Formation that is usually weathered and produced clayey soil. Clayey soil is often acknowledged as problematic soil due to its properties that tend to hold water highly compared to sandy soil, which will cause further engineering problems due to the soil creeping. The study area is prone to landslide activity, especially in the Trusmadi Formation’s slopes. Hence, this paper aims to determine the engineering properties of clayey soil from the Trusmadi Formation. Two slopes were also selected for laboratory analysis and slope inventory. The results of the analysis show that both samples are poorly sorted materials which are classified as sandy and silty clay soil and silty clay soil. The moisture content is 25.98% to 37.10%, specific gravity ranged from 2.52 to 2.57, and plasticity index ranged from 21.68% to 23.91%. The soil has inactive to a normal type of clay (0.59 to 0.97) with a very high swelling capacity (9.29% to 11.43%). The maximum dry density (MDD) ranged from 1.44 to 1.53 and optimum moisture content (OMC) of 25.47% to 25.67%. Also, both samples are classified as impermeable soil with a K value ranging from 1.74x10−8 m/s to 2.45x10−8 m/s. While, based on the slope inventory inspection, both slopes were comprised of metagreywacke, where the first slope was an embankment slope, and the second slope was a cut slope. The first slope has poor vegetation cover which leads to moderate erosion and instability that further caused failure which is rotational debris slide. As for the second slope with average vegetation cover, there is only minor erosion and instability present on the slope, and this slope also shows slow soil movement that indicates soil creep.
Landslide Runout Distance Prediction of Pinousuk Gravel Slope in Mesilou Kundasang, Sabah Using Slope Characterization
Authors: Erfen H F W S , Musta B 
Published: March 2022

Abstract
The study area is located at Mesilou, Kundasang, which focuses on slopes of the Late Pleistocene Pinousuk Gravel unit. This study aims to determine the landslide runout distance (L) against the slope height (H), slope angle (θ), percentage of sand and clay of slope materials. Data were obtained from a shaking table instrument used to simulate earthquake tremors that resulted in landslides. The results show that the higher the slope it is, the farther the runout will occur with correlation, R = 0.87. Based on the slope failure model, the increase of slope angle will add to 60% of the runout distance with R = 0.81, while the longer time of the tremor received increases more than 120% of the distance from the previous point. Results also show insignificant correlation between clay percentage with runout distance (R = 0.23) while higher percentage of sand shows a greater distance from the slope. The greater distance of movement was due to its incohesive and unconsolidated characteristics with correlation, R = 0.64. All the findings show that slope characteristics, such as slope geometry and slope soil properties, influence the distance of landslide runout.
Two Cases Surviving Macro Fat Emboli Complications Following Gluteal Fat Grafting
Authors: Wolfe Erin M , Weber Lee E , Wo Luccie M , Samaha Mario J , Mathew Prakash , Garcia Onelio , Singh Devinder 
Published: March 2022

AbstractMedia attention has in recent years created an increased patient demand for gluteal contouring and augmentation. Gluteal augmentation and contouring with autologous fat transfer, colloquially referred to as the “Brazilian butt lift” (BBL), can be performed safely and effectively, with an overall complication rate ranging from 1.5% to 6.8%. However, there have been an alarming number of lethal events from intravenous passage of injected fat and fatal pulmonary embolism due to macro-fat emboli (MAFE). MAFE (fat emboli &gt;1 cm in diameter), distinct from micro-fat emboli, can quickly result in catastrophic cardiopulmonary compromise and death. Accurate mortality estimates are limited by difficulties in determining accurate values for the total number of BBL procedures performed because most of these cases are performed at budget clinics. Accurate morbidity estimates are limited by a lack of published outcomes and a low level of evidence in published studies. The first case of survival of MAFE secondary to BBL was reported in 2019 by Peña et al. Few highly morbid complications secondary to MAFE have been reported because such events are almost universally lethal. We present 2 recent cases of survival after MAFE in the setting of gluteal fat transfer following expedient transfer to a tertiary care setting, allowing for timely and successful intervention. We illustrate examples of how MAFE is a highly lethal complication of gluteal fat grafting. Early recognition and immediate aggressive vital support to stabilize the patient are key for survival.Level of Evidence: 5
High Intrapulmonary Rifampicin and Isoniazid Concentrations Are Associated With Rapid Sputum Bacillary Clearance in Patients With Pulmonary Tuberculosis
Authors: McCallum Andrew D , Pertinez Henry E , Chirambo Aaron P , Sheha Irene , Chasweka Madalitso , Malamba Rose , Shani Doris , Chitani Alex , Mallewa Jane E , Meghji Jamilah Z , Ghany Jehan F , Corbett Elizabeth L , Gordon Stephen B , Davies Geraint R , Khoo Saye H , Sloan Derek J , Mwandumba Henry C 
Published: March 2022

Abstract

Background
Intrapulmonary pharmacokinetics may better explain response to tuberculosis (TB) treatment than plasma pharmacokinetics. We explored these relationships by modeling bacillary clearance in sputum in adult patients on first-line treatment in Malawi.

Methods
Bacillary elimination rates (BER) were estimated using linear mixed-effects modelling of serial time-to-positivity in mycobacterial growth indicator tubes for sputum collected during the intensive phase of treatment (weeks 0–8) for microbiologically confirmed TB. Population pharmacokinetic models used plasma and intrapulmonary drug levels at 8 and 16 weeks. Pharmacokinetic-pharmacodynamic relationships were investigated using individual-level measures of drug exposure (area-under-the-concentration-time-curve [AUC] and Cmax) for rifampicin, isoniazid, pyrazinamide, and ethambutol, in plasma, epithelial lining fluid, and alveolar cells as covariates in the bacillary elimination models.

Results
Among 157 participants (58% human immunodeficiency virus [HIV] coinfected), drug exposure in plasma or alveolar cells was not associated with sputum bacillary clearance. Higher peak concentrations (Cmax) or exposure (AUC) to rifampicin or isoniazid in epithelial lining fluid was associated with more rapid bacillary elimination and shorter time to sputum negativity. More extensive disease on baseline chest radiograph was associated with slower bacillary elimination. Clinical outcome was captured in 133 participants, with 15 (11%) unfavorable outcomes recorded (recurrent TB, failed treatment, or death). No relationship between BER and late clinical outcome was identified.

Conclusions
Greater intrapulmonary drug exposure to rifampicin or isoniazid in the epithelial lining fluid was associated with more rapid bacillary clearance. Higher doses of rifampicin and isoniazid may result in sustained high intrapulmonary drug exposure, rapid bacillary clearance, shorter treatment duration and better treatment outcomes.
Some Recent Developments IN The Explanation of The Empirical Relationship Between Prices and Distribution
Authors: Ferrer-Hernández Jacobo , Torres-González Luis Daniel 
Published: March 2022

Abstract
The paper complements recent contributions towards the explanation of the regularities in the behaviour of prices and capital intensities as an effect of hypothetical changes in the rate of profits in empirical production-price models. It is shown that theoretical price and capital curves, i.e. prices and capital values as a function of the rate of profits, depend on the product of the eigenvalues and what we call the eigenlabours —the representation of the labour vector in the space spanned by the eigenvectors of the input matrix. We report robust evidence that the eigenvalues by themselves cannot produce the curves regularly reported in the literature, but rather it is the joint action of the eigenvalues and the eigenlabours. It is conjectured that the tendency towards zero of the subdominant eigenlabours is driven by the statistical tendency towards proportionality between the labour vector and the Perron–Frobenius eigenvector of the input matrix.
https://invertebratefungi.org/: an expert-curated web-based platform for the identification and classification of invertebrate-associated fungi and fungus-like organisms
Authors: Wei De-Ping , Gentekaki Eleni , Hyde Kevin D , Xiao Yuan-Pin , Luangharn Thatsanee , Tian Qing , Wang Yuan-Bing , Lumyong Saisamorn 
Published: March 2022

Abstract
Fungi are the major decomposers in terrestrial and aquatic ecosystems, playing essential roles in biogeochemical cycles and food webs. The Fungi kingdom encompasses a diverse array of taxa that often form intimate relationships with other organisms, including plants, insects, algae, cyanobacteria and even other fungi. Fungal parasites of insects are known as entomopathogenic fungi and are the causative agents of serious disease and/or mortality of their hosts. Entomopathogens produce distinct metabolic compounds with roles in pathogenicity, virulence and host–parasite interactions. Thus, the potential of discovering new bioactive compounds useful in biocontrol and pharmaceutical industries is high. Given the significance of entomopathogenic fungi, the rapid research advances and the increased interest, it has become necessary to organize all available and incoming data. The website https://invertebratefungi.org/ has been developed to serve this purpose by gathering and updating entomopathogenic genera/species information. Notes of entomopathogenic genera will be provided with emphasis on their taxonomic status. Information on other invertebrates, such as rotifers, will also be included. Descriptions, photographic plates, information on distribution and host (where applicable) along with molecular data and other interesting details will also be provided. The website is easily and freely accessible to users. Instructions concerning the platform architecture and functionality of the website are introduced herein. The platform is currently being expanded and will be continuously updated as part of the effort to enrich knowledge on this group of fungi.
Database URL: https://invertebratefungi.org/
Virtual Borders: International Law and the Elusive Inequalities of Algorithmic Association
Authors: Van Den Meerssche Dimitri 
Published: March 2022

Abstract
The use of algorithmic tools by international public authorities is changing how norms are made and enacted. This seismic shift in global governance has important distributive consequences: the digital turn not only empowers specific corporate actors and forms of expertise but also entails new modes of social sorting based on the placement of people in patterns of data. This article focuses on the emergent inequalities that machine learning and data analytics thereby import in the domain of global governance. In line with the symposium’s theme, I thereby frame the importance of computational decision-making processes from a distributional, and not a procedural, perspective – from a perspective of inequality and not privacy, data protection or transparency. The empirical site for the assessment of these emergent inequalities is the ‘virtual border’. By focusing on the technological tools of data extraction and algorithmic risk assessment that are reshaping practices of border control, the article makes a dual contribution: it reveals the social hierarchies engendered by these data-driven forms of grouping and grading – captured in the novel concept of ‘associative inequality’ – and highlights the difficulty of registering or counteracting this mode of subject-making in existing legal terms. This intervention both traces the particular distributive effects of data-driven governance and signals the challenges it poses to the prospects and emancipatory promises of collectivity, solidarity and equality entertained in modernist ideals of international law. In resisting the logic of algorithmic governance, I suggest, we should strive not for transparency but for opacity, not inclusion but incomparability, not privacy but open-ended and defiant commonality.
Decrease in the prevalence of hypertension in Spanish schoolchildren from 2010 to 2017: Cuenca Study
Authors: Martin-Espinosa Noelia , Martínez-Vizcaíno Vicente , Garrido-Miguel Miriam , Díez-Fernández Ana , Isabel Cobo-Cuenca Ana , Solera-Martínez Montserrat 
Published: March 2022

AbstractAimsTo examine the secular trends in blood pressure measurements and normal or high blood pressure classification among Spanish schoolchildren from 2010 to 2017, to analyze the persistence in the blood pressure category reported in 2017 compared with 2013 in those children born in 2007–08 and to compare in this cohort the prevalence of high blood pressure using both definitions, the 2004 and 2017 guidelines.Methods and resultsThe data for the prevalence/trend analysis were obtained from cross-sectional analyses conducted in 2010, 2013, and 2017 of 2709 schoolchildren aged 4–6 and 8–11 years from 22 schools in the province of Cuenca, Spain. The data for the longitudinal analysis were obtained from cross-sectional analyses of measurements gathered in 2013 and 2017 in the same cohort of children (n = 275). The prevalence of normal blood pressure increased by 5.4% in children aged 4–6 years from 2013 to 2017 and by 2.2% in children aged 8–11 from 2010 to 2017. This increase was mainly driven by a decrease in the children classified in any stage of hypertension by 4.2% and 2.3% in each age range, respectively. In the same birth cohort, there was an increase of 7.6% in normal blood pressure prevalence.ConclusionThe high blood pressure prevalence in Spanish children has clearly decreased over the last decade, but is still important to detect this condition to design specific school-based interventions and the evaluation of children classified as hypertensive who might need medical supervision and treatment.
Positioning Van Leeuwenhoek's microscopes in 17th-century microscopic practice
Authors: Cocquyt Tiemen 
Published: March 2022

Abstract
The self-made nature of Antoni van Leeuwenhoek's discoveries and microscopes tends to obscure the rich and dynamic 17th-century culture of microscopy that preceded his work. Rather than being limited by available magnifications, 17th-century microscopy was shaped by philosophical paradigms, visual and preparation techniques, and observation conditions. Taking into account new insights into his lens making methods, a comparison of Van Leeuwenhoek's methodology with 17th-century predecessors reveals, on the one hand, how his work was rooted in existing traditions, while on the other hand it makes us appreciate his innovations better. Van Leeuwenhoek elegantly turned the viewing practice associated with high-magnification microscopy into a convincing narrative. In doing so, he reaffirmed the central role of the microscope in the 17th-century inquiry of nature. This allowed him to open up new vistas and become the founder of microbiology.
Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy
Authors: Mach John , Kane Alice E , Howlett Susan E , Sinclair David A , Hilmer Sarah N 
Published: March 2022

Abstract
The Frailty Inferred Geriatric Health Timeline (FRIGHT) and Analysis of Frailty and Death (AFRAID) clocks were developed to predict biological age and lifespan, respectively, in mice. Their utility within the context of polypharmacy (≥5 medications), which is very common in older adults, is unknown. In male C57BL/6J(B6) mice administered chronic polypharmacy, monotherapy, and undergoing treatment cessation (deprescribing), we aimed to compare these clocks between treatment groups; investigate whether treatment affected correlation of these clocks with mortality; and explore factors that may explain variation in predictive performance. Treatment (control, polypharmacy, or monotherapy) commenced from age 12 months. At age 21 months, each treatment group was subdivided to continue treatment or have it deprescribed. Frailty index was assessed and informed calculation of the clocks. AFRAID, FRIGHT, frailty index, and mortality age did not differ between continued treatment groups and control. Compared to continued treatment, deprescribing some treatments had inconsistent negative impacts on some clocks and mortality. FRIGHT and frailty index, but not AFRAID, were associated with mortality. The bias and precision of AFRAID as a predictor of mortality varied between treatment groups. Effects of deprescribing some drugs on elements of the clocks, particularly on weight loss, contributed to bias. Overall, in this cohort, FRIGHT and AFRAID measures identified no treatment effects and limited deprescribing effects (unsurprising as very few effects on frailty or mortality), with variable prediction of mortality. These clocks have utility, but context is important. Future work should refine them for intervention studies to reduce bias from specific intervention effects.
Association Between Free-Living Sit-to-Stand Transition Characteristics, and Lower-Extremity Performance, Fear of Falling, and Stair Negotiation Difficulties Among Community-Dwelling 75 to 85-Year-Old Adults
Authors: Löppönen Antti , Karavirta Laura , Koivunen Kaisa , Portegijs Erja , Rantanen Taina , Finni Taija , Delecluse Christophe , Van Roie Evelien , Rantalainen Timo 
Published: March 2022

Abstract

Background
Good sit-to-stand (STS) performance is an important factor in maintaining functional independence. This study investigated whether free-living STS transition volume and intensity, assessed by a thigh-worn accelerometer, is associated with characteristics related to functional independence.

Methods
Free-living thigh-worn accelerometry was recorded continuously for 3–7 days in a population-based sample of 75-, 80-, and 85-year-old community-dwelling people (479 participants; women n = 287, men n = 192). The records were used to evaluate the number and intensity (angular velocity of the STS phase) of STS transitions. Associations with short physical performance battery (SPPB), 5-times-sit-to-stand test (5×STS), isometric knee extension force, self-reported fear of falls, and self-reported difficulty in negotiating stairs were also assessed.

Results
The number of STS transitions, mean and maximal angular velocity were lower in older age groups (p &lt; .05). All variables were higher in men than in women (p &lt; .001) and were positively associated with SPPB total points, knee extension force (r ranged from 0.18 to 0.39, all p &lt; .001) and negatively associated with 5×STS (r = −0.13 – −0.24, all p &lt; .05), lower extremity functional limitations (p &lt; .01), fear of falls (p &lt; .01), and stair negotiation difficulties (p &lt; .01).

Conclusions
Free-living STS characteristics were related to lower-extremity performance, lower extremity functional limitations, self-reported fear of falls, and stair negotiation difficulties, which can be a sensitive indicator of impending functional decline. Moreover, STS transitions may provide an indicator of adequacy of lower-limb muscle strength among older individuals.
Addressing Suicide Risk in Patients Living With Dementia During the COVID-19 Pandemic and Beyond
Authors: Portacolone Elena , Byers Amy L , Halpern Jodi , Barnes Deborah E 
Published: March 2022

Abstract
Alzheimer’s disease and related dementias (ADRD) are progressive illnesses characterized by decline in cognitive function that impairs performing daily activities. People with ADRD are at an increased risk of suicide, especially those who have comorbid mental health conditions, have specific types of ADRD, or have been recently diagnosed. The coronavirus disease 2019 (COVID-19) pandemic has increased the distress of people with ADRD, a population also at increased risk of contracting the COVID-19 virus. In this article, we draw on a case study and use the Interpersonal Theory of Suicide to help describe the association between ADRD and suicide risk. Secondly, we call for new strategies to mitigate suicide risk in people living with ADRD during and beyond the current pandemic by using lessons learned from cancer care. Our goal is not to dictate solutions but rather to start the conversation by outlining a framework for future research aimed at preventing death by suicide in people with ADRD. Specifically, we draw on the updated Framework for Developing and Evaluating Complex Interventions to reflect on the complexity of the issue and to break it down into achievable parts to reduce the risk of suicidal behavior (ideation, plans, attempts) in those living with ADRD.
Interrupting pathways to health inequities in citizen science health research
Authors: Pierce Robin L 
Published: March 2022

SummaryParticipatory research in multiple forms is rapidly gaining ground and stands to provide valuable benefits in the area of health research. Citizen science, an increasingly popular form of participatory research, aims to involve laypersons in knowledge production and, as such, can offer new insights that may not be readily accessible by the traditional scientific research enterprise. Heralded as an advance in the democratization of science, citizen science stands as a potential player in evidence generation. Yet, while citizen science offers advantages through its emphasis on lay participation in uncovering information likely to be pertinent to improving health outcomes, without deliberate attention to pathways to inequity and oversight, some aspects can operate to perpetuate or exacerbate health inequities. Drawing on health disparities literature to assist in identifying possible pathways, this work aims to provide support for greater attention to ‘process’, which would include active engagement with intersecting inequities as a way of interrupting pathways to health inequity. If citizen science is to be true to its moniker, it cannot be ‘equity-neutral’ in a society where structural or systemic inequities are present. It must be equity-promoting. In the health context, the concerns of justice evolve into concerns of differential health impacts. To accomplish this, equity and justice, as well as representation and fair process, become critically important. Accordingly, this paper foregrounds proactive commitment to equity by confronting the reality of social inequalities present in a given society and adapting the project accordingly to minimize downstream health inequities.