bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes With a Mobile Digital Health Platform for Patients Undergoing Spine Surgery: Retrospective Analysis
Authors: Venkatraman Vishal , Kirsch Elayna P , Luo Emily , Kunte Sameer , Ponder Madison , Gellad Ziad F , Liu Beiyu , Lee Hui-Jie , Jung Sin-Ho , Haglund Michael M , Lad Shivanand P 
Published: October 2022

Background
Digital health solutions have been shown to enhance outcomes for individuals with chronic medical illnesses, but few have been validated for surgical patients. The digital health platform ManageMySurgery (MMS) has been validated for spine surgery as a feasible method for patients along their surgical journey through in-app education and completion of patient-reported outcomes surveys.

Objective
The aim of this study is to determine the rates of 90-day emergency room (ER) visits, readmissions, and complications in patients undergoing spine surgery using MMS compared to patients using traditional perioperative care alone.

Methods
Patients undergoing spine surgery at a US-based academic hospital were invited to use MMS perioperatively between December 2017 and September 2021. All patients received standard perioperative care and were classified as MMS users if they logged into the app. Demographic information and 90-day outcomes were acquired via electronic health record review. The odds ratios of having 90-day ER visits, readmissions, mild complications, and severe complications between the MMS and non-MMS groups were estimated using logistic regression models.

Results
A total of 1015 patients were invited, with 679 using MMS. MMS users and nonusers had similar demographics: the average ages were 57.9 (SD 12.5) years and 61.5 (SD 12.7) years, 54.1% (367/679) and 47.3% (159/336) were male, and 90.1% (612/679) and 88.7% (298/336) had commercial or Medicare insurance, respectively. Cervical fusions (559/1015, 55.07%) and single-approach lumbar fusions (231/1015, 22.76%) were the most common procedures for all patients. MMS users had a lower 90-day readmission rate (55/679, 8.1%) than did nonusers (30/336, 8.9%). Mild complications (MMS: 56/679, 8.3%; non-MMS: 32/336, 9.5%) and severe complications (MMS: 66/679, 9.7%; non-MMS: 43/336, 12.8%) were also lower in MMS users. MMS users had a lower 90-day ER visit rate (MMS: 62/679, 9.1%; non-MMS: 45/336, 13.4%). After adjustments were made for age and sex, the odds of having 90-day ER visits for MMS users were 32% lower than those for nonusers, but this difference was not statistically significant (odds ratio 0.68, 95% CI 0.45-1.02; P=.06).

Conclusions
This is one of the first studies to show differences in acute outcomes for people undergoing spine surgery who use a digital health app. This study found a correlation between MMS use and fewer postsurgical ER visits in a large group of spine surgery patients. A planned randomized controlled trial will provide additional evidence of whether this digital health tool can be used as an intervention to improve patient outcomes.
A Voice App Design for Heart Failure Self-management: Proof-of-Concept Implementation Study
Authors: Barbaric Antonia , Munteanu Cosmin , Ross Heather , Cafazzo Joseph A 
Published: October 2022

Background
Voice user interfaces are becoming more prevalent in health care and are commonly being used for patient engagement. There is a growing interest in identifying the potential this form of interface has on patient engagement with digital therapeutics (DTx) in chronic disease management. Making DTx accessible through an alternative interaction model also has the potential to better meet the needs of some patients, such as older adults and those with physical and cognitive impairments, based on existing research.

Objective
This study aimed to evaluate how participants with heart failure interacted with a voice app version of a DTx, Medly, through a proof-of-concept implementation study design. The objective was to understand whether the voice app would enable the participants to successfully interact with the DTx, with a focus on acceptability and feasibility.

Methods
A mixed methods concurrent triangulation design was used to better understand the acceptability and feasibility of the use of the Medly voice app with the study participants (N=20) over a 4-week period. Quantitative data included engagement levels, accuracy rates, and questionnaires, which were analyzed using descriptive statistics. Qualitative data included semistructured interviews and were analyzed using a qualitative descriptive approach.

Results
The overall average engagement level was 73% (SD 9.5%), with a 14% decline between results of weeks 1 and 4. The biggest difference was between the average engagement levels of the oldest and youngest demographics, 84% and 43%, respectively, but these results were not significant—Kruskal-Wallis test, H(2)=3.8 (P=.14). The Medly voice app had an overall accuracy rate of 97.8% and was successful in sending data to the clinic. From an acceptability perspective, the voice app was ranked in the 80th percentile, and overall, the users felt that the voice app was not a lot of work (average of 2.1 on a 7-point Likert scale). However, the overall average score for whether users would use it in the future declined by 13%. Thematic analysis revealed the following: the theme feasibility of clinical integration had 2 subthemes, namely users adapted to the voice app’s conversational style and device unreliability, and the theme voice app acceptability had 3 subthemes, namely the device integrated well within household and users’ lives, users blamed themselves when problems arose with the voice app, and voice app was missing specific, desirable user features.

Conclusions
In conclusion, participants were largely successful in using the Medly voice app despite some of the barriers faced, proving that an app such as this could be feasible to be deployed in the clinic. Our data begin to piece together the patient profile this technology may be most suitable for, namely those who are older, have flexible schedules, are confident in using technology, and are experiencing other medical conditions.
A Qualitative Content Analysis of Comments on Press Articles on Deemed Consent for Organ Donation in Canada
Authors: Fox Danielle E. , Donald Maoliosa , Chong Christy , Quinn Robert R. , Ronksley Paul E. , Elliott Meghan J. , Lam Ngan N. 
Published: October 2022

Background and objectives
In 2019, two Canadian provinces became the first jurisdictions in North America to pass deemed consent legislation to increase deceased organ donation and transplantation rates. We sought to explore the perspectives of the deemed consent legislation for organ donation in Canada from the viewpoint of individuals commenting on press articles.

Design, setting, participants, & measurements
In this qualitative descriptive study, we extracted public comments regarding deemed consent from online articles published by four major Canadian news outlets between January 2019 and July 2020. A total of 4357 comments were extracted from 35 eligible news articles. Comments were independently analyzed by two research team members using a conventional content analysis approach.

Results
Commenters’ perceptions of the deemed consent legislation for organ donation in Canada predominantly fit within three organizational groups: perceived positive implications of the bills, perceived negative implications of the bills, and key considerations. Three themes emerged within each group that summarized perspectives of the proposed legislation. Themes regarding the perceived positive implications of the bills included majority rules, societal effect, and prioritizing donation. Themes regarding the perceived negative implications of the bills were a right to choose, the potential for abuse and errors, and a possible slippery slope. Improving government transparency and communication, clarifying questions and addressing concerns, and providing evidence for the bills were identified as key considerations.

Conclusions
If deemed consent legislation is meant to increase organ donation and transplantation, addressing public concerns will be important to ensure successful implementation.
Orientações de proteção radiológica pós-terapia para pacientes submetidos à radioiodoterapia: uma revisão integrativa
Authors: Cagol Camozzato Tatiane Sabriela , Ejidike Adaobi Bianca , Oliveira Pires Luciana , Dorrow Patrícia Fernanda 
Published: October 2022

Resumo
A Radioiodoterapia é um método terapêutico que de forma eficaz utiliza o NaI-131 no tratamento de doenças benignas. Este radiofármaco possui meia-vida de 8,02 dias, para este período ao paciente e a seus familiares devem ser disponibilizadas orientações que mantenham a dose do público inferior aos limites recomendados. Este artigo tem como objetivo analisar onde, de que forma e em qual direção ocorrem as publicações direcionadas ao período de isolamento domiciliar para pacientes submetidos à radioiodoterapia. Realizou-se uma revisão integrativa na base de dados SCOPUS com as palavras-chave. Foi realizada a leitura dos resumos e posterior classificação de acordo com o tema e disponibilidade do texto na íntegra. Foram listados 45 artigos destes 26 foram elegíveis, com origem predominantemente dos Estados Unidos (7), China, Irã e Reino Unido, 7 (3 cada), tendo a maior parte das publicações ocorrido nos anos de 2014 (4) e 2006 (3). É unânime a opinião de que as instruções existentes se corretamente seguidas são suficientes para manter o público em segurança. Quanto à direção, a grande maioria se destina a medir e avaliar a exposição dos familiares no ambiente doméstico. A questão mais discutida é a formulação de orientações a partir de taxas de dose instantânea ou retenção de iodo, considerando os interesses ou as condições socioeconômicas de cada paciente e os estudos que confrontam o valor da dose recebida por familiares mediante uso de dosímetro.
Qual o papel da ultrassonografia pulmonar point-of-care em pacientes infectados pelo covid-19?- uma revisão integrativa
Authors: Schittini Barreto Rafaela Ferreira , Barbosa de Matos Douglas Aparecido , De Vasconcelos Pedro Fonseca 
Published: October 2022

Tendo em vista os diversos padrões de acometimento pulmonar encontrados nos pacientes infectados pelo Coronavírus 2019 (COVID-19), o acompanhamento diário ou sequencial da evolução da imagem pulmonar é um dado fundamental no raciocínio e seguimento terapêutico de pacientes que atingem níveis de gravidade elevados (Síndrome do Desconforto Agudo Respiratório e necessidade de altas concentrações de oxigênio suplementar). Eis que o ultrassom pulmonar, já utilizado como modalidade diagnóstica bem estabelecida no conceito point-of-care da medicina de emergência e na terapia intensiva, assume um papel importante no contexto da pandemia pela doença do COVID-19, devido à boa correlação dos seus achados com a tomografia computadorizada e suas vantagens, como a possibilidade de realizá-lo à beira do leito sem necessidade de transporte para outro setor, baixo custo, ausência de radiação, além de permitir follow-up diário do acometimento pulmonar dos pacientes. Esse estudo trata-se de uma revisão integrativa da literatura, compreendendo artigos publicados entre 2019 e 2020, disponíveis nas bases de dados Scielo e PubMed, cujo objetivo é o de fornecer uma visão geral do papel da ultrassonografia pulmonar no diagnóstico, processo de tomada de decisão terapêutica e monitoramento da pneumonia COVID-19.
Os beneficios da hidroterapia em crianças com transtorno espectro autista (tea): revisão integrativa
Authors: Leite Ferreira Aline Steffani , Quariguasi Ferreira Johnathan Allyson 
Published: October 2022

O transtorno espectro autista é definido como um transtorno do neurodesenvolvimento, que se manifesta precoce durante a infância, ele é invasivo e abrange alterações rigorosas precocemente nas áreas de socialização, comunicação e cognição. A hidroterapia é um dos recursos mais antigos da fisioterapia, sendo definida e como o uso externo da água com propósitos terapêuticos, que é utilizada os efeitos físicos, fisiológicos e cinesiológicos, auxiliando na reabilitação ou na prevenção de alterações funcionais. A hidroterapia são de extrema importância para o desenvolvimento da criança com transtorno espectro autista, pois ela oferece grandes benefícios fisico, motor, força muscular, comportamento social, mental, segurança e relação com a água. Além da autonomia individual que as crianças são constantemente instigadas para beneficiar a qualidade de vida. O objetivo do trabalho foi analisar os benefícios da hidroterapia sendo utilizado como alternativa de tratamento em crianças com transtorno espectro autista. O presente estudo trata-se de uma pesquisa qualitativa, descritiva, baseada na análise bibliográfica. Para coletas de dados foram realizadas pesquisas nas bases de dados científicas: PubMed e PEDro. Os descritores foram utilizados conforme os Descritores em Ciências da Saúde - DeCS/MeSH. Dentre os artigos encontrados, foram inclusos artigos dos anos 2016 a 2021 nos idiomas inglês e português que abordassem o tema proposto. Apresentaram que a hidroterapia é capaz de promover uma melhora no aspecto físico, motor, força muscular, cognitivo, relação social e sócio-afetivo das crianças com transtorno espectro autista. Concluímos, assim, que a hidroterapia é de grande valia para promoção de uma vida de qualidade para essas crianças. Este estudo teve como finalidade investigar os benefícios da hidroterapia em crianças com transtorno espectro autista. Assim, essa revisão integrativa demonstrou a notável relevância das técnicas fisioterapêuticas e evidenciou sua aplicabilidade, indicando uma melhora significativa dos benefícios esses, que ultrapassam os âmbitos físico, motor, cognitivo e sócio-afetivo, e são capazes de melhorar significativamente a qualidade de vida das crianças com TEA
The Dual-Role Framework: A Structured Approach for Analyzing Management Controls
Authors: Bol Jasmijn C. , Loftus Serena 
Published: October 2022

ABSTRACT
We provide a conceptual framework for analyzing studies on management controls and management control systems (MCSs). This framework describes and analyzes the directing and activating processes of management controls and MCSs. Because our focus is on why management controls are effective, our conceptual framework complements earlier frameworks that focus on specific empirical methods, controls, and literature maps. We discuss several applications of the framework, such as depicting an individual research study, comparing multiple research studies examining the same control, and organizing an area of research. Our approach benefits consumers of management accounting research by increasing understanding and access to extant research. In addition, the application of our approach can reveal gaps in the literature or the potential for mediating factors to explain conflicting findings and can thus inform future research.
Banking Market Consolidation and Tax Planning Intermediation: Evidence from Client Firm Tax Haven Operations
Authors: Kim Jeong-Bon , Lin Yupeng , Mao Ying , Wang Zheng 
Published: October 2022

ABSTRACT
This study examines the effect of banking market consolidations via mergers and acquisitions (M&As) on the role of banks in intermediating corporate tax planning through offshore tax haven operations. We find that bank clients significantly increase their tax haven operations after their banks are merged with others. In addition, such an increase is greater when a commercial bank merges with an investment bank and when the clients have greater tax planning opportunities. We also employ network analyses to show that the propensity for a client to expand its operations into a new tax haven country increases significantly when its relationship bank enters into this country through an M&A. Collectively, our findings reveal that bank M&As enhance banks’ tax intermediation capability.
Diabetes-Related Excess Mortality in Mexico: A Comparative Analysis of National Death Registries Between 2017–2019 and 2020
Authors: Bello-Chavolla Omar Yaxmehen , Antonio-Villa Neftali Eduardo , Fermín-Martínez Carlos A. , Fernández-Chirino Luisa , Vargas-Vázquez Arsenio , Ramírez-García Daniel , Basile-Alvarez Martín Roberto , Hoyos-Lázaro Ana Elena , Carrillo-Larco Rodrigo M. , Wexler Deborah J. , Manne-Goehler Jennifer , Seiglie Jacqueline A. 
Published: October 2022

OBJECTIVE
To estimate diabetes-related mortality in Mexico in 2020 compared with 2017–2019 after the onset of the coronavirus disease 2019 (COVID-19) pandemic.

RESEARCH DESIGN AND METHODS
This retrospective, state-level study used national death registries of Mexican adults aged ≥20 years for the 2017–2020 period. Diabetes-related death was defined using ICD-10 codes listing diabetes as the primary cause of death, excluding certificates with COVID-19 as the primary cause of death. Spatial and negative binomial regression models were used to characterize the geographic distribution and sociodemographic and epidemiologic correlates of diabetes-related excess mortality, estimated as increases in diabetes-related mortality in 2020 compared with average 2017–2019 rates.

RESULTS
We identified 148,437 diabetes-related deaths in 2020 (177 per 100,000 inhabitants) vs. an average of 101,496 deaths in 2017–2019 (125 per 100,000 inhabitants). In-hospital diabetes-related deaths decreased by 17.8% in 2020 versus 2017–2019, whereas out-of-hospital deaths increased by 89.4%. Most deaths were attributable to type 2 diabetes (130 per 100,000 inhabitants). Compared with 2018–2019 data, hyperglycemic hyperosmolar state and diabetic ketoacidosis were the two contributing causes with the highest increase in mortality (128% and 116% increase, respectively). Diabetes-related excess mortality clustered in southern Mexico and was highest in states with higher social lag, rates of COVID-19 hospitalization, and prevalence of HbA1c ≥7.5%.

CONCLUSIONS
Diabetes-related deaths increased among Mexican adults by 41.6% in 2020 after the onset of the COVID-19 pandemic, occurred disproportionately outside the hospital, and were largely attributable to type 2 diabetes and hyperglycemic emergencies. Disruptions in diabetes care and strained hospital capacity may have contributed to diabetes-related excess mortality in Mexico during 2020.
Using data to improve the management of diabetes – the Tayside experience
Authors: Siddiqui Moneeza K , Hall Christopher , Cunningham Scott G , McCrimmon Rory , Morris Andrew , Leese Graham P , Pearson Ewan R 
Published: October 2022

<p> </p>
<p>Tayside is a region in the East of Scotland and forms one of nine local government regions in the country. It is home to approximately 416,000 individuals who fall under the National Health Service Tayside (NHS Tayside) health board who provide healthcare services to the population. In Tayside, Scotland a comprehensive informatics network for diabetes care and research has been established for over 25 years, expanding more recently to a comprehensive Scotland-wide clinical care system, Scottish Care Information-Diabetesor SCI-Diabetes. This has enabled improved diabetes screening, integrated management of diabetic retinopathy, neuropathy, nephropathy, cardiovascular health, and other comorbidities. The regional health informatics network links all these specialized services with comprehensive laboratory testing, prescribing records, general practitioner records, and hospitalization records. Not only do patients benefit from the seamless interconnectedness of these data, the Tayside bioresource has enabled considerable research opportunities and the creation of biobanks. This review describes how health informatics has been used to improve care of people diabetes in Tayside and Scotland and, through anonymized data linkage, our understanding of the phenotypic and genotypic etiology of diabetes and associated complications and co-morbidities.</p>
Dynamic Ins2 gene activity defines β-cell maturity states
Authors: Chu Chieh Min Jamie , Modi Honey , Ellis Cara , Krentz Nicole A.J. , Skovsø Søs , Zhao Yiwei Bernie , Cen Haoning , N Noursadeghi , Panzhinskiy Evgeniy , Hu Xiaoke , Dionne Derek A. , Xia Yi Han , Xuan Shouhong , Huising Mark O. , Kieffer Timotyh J. , Lynn Francis C. , Johnson James D. 
Published: October 2022

<p>Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We investigated the temporal kinetics of endogenous insulin gene activity using live cell imaging, with complementary experiments employing FACS and single cell RNA sequencing, in β-cells from <em>Ins2</em>GFP knock-in mice. <em>In vivo</em> staining and FACS analysis of islets from <em>Ins2</em>GFP mice confirmed that at a given moment, ~25% of β-cells exhibited significantly higher activity at the evolutionarily conserved insulin gene <em>Ins2</em>. Live cell imaging over days captured <em>Ins2</em> gene activity dynamics in single β-cells. Autocorrelation analysis revealed a subset of oscillating cells, with mean oscillation periods of 17 hours. Increased glucose concentrations stimulated more cells to oscillate and resulted in higher average <em>Ins2</em> gene activity per cell. Single cell RNA sequencing showed that <em>Ins2</em>(GFP)HIGH β-cells were enriched for markers of β-cell maturity. <em>Ins2</em>(GFP)HIGH β-cells were also significantly less viable at all glucose concentrations and in the context of ER stress. Collectively, our results demonstrate that the heterogeneity of insulin production, observed in mouse and human β-cells, can be accounted for by dynamic states of insulin gene activity. </p>