bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study protocol: Effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients
Authors: Paneerselvam Ganesh Sritheran , Aftab Raja Ahsan , Sirisinghe Roland Gamini , Lai Pauline Siew Mei , Lim Soo Kun 
Published: February 2022

BackgroundPatients requiring hemodialysis (HD) often have several chronic comorbidities, which necessitate the use of several medications and hence put them at high risk of polypharmacy. Medication-related problems (MRPs) among HD patients are a serious issue as they can increase morbidity and nonadherence with medications. To overcome this issue, a unique pharmacy practice model including medication review (MR) and motivational interviewing (MI) is needed to improve medication adherence, by reducing MRPs and optimizing therapeutic outcomes. The present study aims to assess the effectiveness of MR and MI in improving medication adherence, quality of life (QOL) and clinical outcomes among end-stage renal disease (ESRD) patients who are on dialysis.Method and designThis pre-post study will be conducted prospectively among patients with ESRD who have been on dialysis at the Hemodialysis Unit, Hospital Kuala Lumpur and the Hemodialysis Affiliated Centers of the University Malaya Medical Centre, from August 2020 till August 2021. Medication adherence will be assessed using the General Medication Adherence Scale (GMAS), whilst patients’ HRQOL will be assessed using the Kidney Disease Quality of Life Short Form 36 (KDQOL-36). Clinical parameters such as blood glucose level, calcium, phosphate, hemoglobin and serum low-density lipoprotein (LDL) levels will be obtained from medical records. A total of 70 patients will be recruited.DiscussionWe hypothesize that the implementation of pharmacy-based MR and MI may expect an increase in medication adherence scores and increase in HRQOL scores from baseline as well as achieving the clinical lab parameters within the desired range. This would indicate a need for a pharmacist to be involved in the multidisciplinary team to achieve a positive impact on medication adherence among hemodialysis patients.Trial registrationEthical approval has been obtained from the National Medical Research and Ethics Committee NMRR:20-1135-54435and Medical Research Ethics Committee, University Malaya Medical Centre MREC ID NO:202127-9811.
Nurses’ use of social media during the COVID-19 pandemic—A scoping review
Authors: Glasdam Stinne , Sandberg Helena , Stjernswärd Sigrid , Jacobsen Frode F. , Grønning Anette H. , Hybholt Lisbeth 
Published: February 2022

Background
During the COVID-19 pandemic, nurses stand in an unknown situation while facing continuous news feeds. Social media is a ubiquitous tool to gain and share reliable knowledge and experiences regarding COVID-19. The article aims to explore how nurses use social media in relation to the COVID-19 pandemic.

Method
A scoping review inspired by Arksey and O’Mally was conducted by searches in Medline, CINAHL, Academic Search Complete and Web of Sciences. Empirical research studies investigating nurses’ use of social media in relation to COVID-19 were included. Exclusion criteria were: Literature reviews, articles in languages other than English, articles about E-health, and articles investigating healthcare professionals without specification of nurses included. Articles, published in January-November 2020, were included and analysed through a thematic analysis. The PRISMA-ScR checklist was used.

Results
Most of the eleven included studies were cross-sectional surveys, conducted in developing countries, and had neither social media nor nurses as their main focus of interest. Three themes were identified: ‘Social media as a knowledge node’, ‘Social media functioned as profession-promoting channels’ and ‘Social media as a disciplinary tool’. Nurses used social media as channels to gain and share information about COVID-19, and to support each other by highlighting the need for training and changes in delivery of care and redeployment. Further, social media functioned as profession-promoting channels partly sharing heroic self-representations and acknowledgment of frontline persons in the pandemic, partly by displaying critical working conditions. Finally, nurses used social media to educate people to perform the ‘right ‘COVID-19’ behaviours in society.

Conclusion
This review provided snapshots of nurses’ uses of social media from various regions in the world, but revealed a need for studies from further countries and continents. The study calls for further multi-methodological and in depth qualitative research, including theoretically framed studies, with a specific focus on the uses of social media among nurses during the pandemic.
Prevalence of anemia and associated factors among adult diabetic patients attending Bale zone hospitals, South-East Ethiopia
Authors: Solomon Damtew , Bekele Kebebe , Atlaw Daniel , Mamo Ayele , Gezahegn Habtamu , Regasa Tadele , Negash Getahun , Nigussie Eshetu , Zenbaba Demissu , Teferu Zinash , Nugusu Fikadu , Atlie Gela 
Published: February 2022

Background
Anemia found in diabetes patients is often unrecognized like many other chronic diseases. The occurrence of anemia is also an additional burden to the micro vascular complications of patients with diabetes. In the selected study structure no published data were found on the prevalence of anemia and associated factors in diabetic patients. Hence, the findings of this study are very fruitful as an input for further studies and after the repetition of similar studies in different frameworks. It is helpful as input for the development of guidelines at diabetes clinics to request the laboratory assessment of hemoglobin as a routine activity.

Objective
This study aimed to assess the prevalence of anemia and its associated factors among diabetic patients who attended Bale zone hospitals.

Methods
A cross-sectional study design was conducted from September 2020–to January 2021 GC among adult diabetic patients who had follow-up at Bale zone hospitals. A total of 238 study participants were determined by single population proportion sample size calculation formula taking prevalence of anemia among adult diabetic patients 19.0%. Systematic random sampling technique was used to select the study participants. Information on demographic and associated factors of anemia in diabetic patients was collected using an interviewer-administered questionnaire. Blood sample collection was performed under aseptic conditions by a licensed medical laboratory professional. Data were entered into EpiData version 3.1, cleaned and exported to statistical package for the social sciences (SPSS) version 25 software tools. Logistic regression was used to assess factors associated with anemia in diabetic patients. P-value less than 0.05 and 95% CI were considered as statistically significant. The odds ratios were reported to indicate the strength of associations. Frequencies, percentages, charts and tables were used to summarize the characteristics of study participants.

Results
In this study anemia among adult diabetic patients is 18.1% (95% CI (13.2, 23.0%). Multivariable logistic regression analysis revealed that the sex of the study participants and the type of diabetes mellitus were found to be statistically significant to associate with anemia. The odds of having anemia among females are nearly three times higher when compared with males (AOR 2.78, 95% CI 1.40–5.52). In addition, the odds of having anemia among adult diabetic patients who had type II diabetes mellitus (AOR 2.18, 95%CI 1.04–4.54) were 2.18 times higher than those who had type I diabetes mellitus patients.

Conclusion
Nearly one out of five adult diabetic patients had anemia. Sex of the patients and the type of diabetes are associated with anemia among adult diabetic patients.
‘We felt like part of a production system’: A qualitative study on women’s experiences of mistreatment during childbirth in Switzerland
Authors: Meyer Stephanie , Cignacco Eva , Monteverde Settimio , Trachsel Manuel , Raio Luigi , Oelhafen Stephan 
Published: February 2022

Introduction
Mistreatment during childbirth is an issue of global magnitude that not only violates fundamental human rights but also seriously impacts women’s well-being. The purpose of this study was to gain a better understanding of the phenomenon by exploring the individual experiences of women who reported mistreatment during childbirth in Switzerland.

Materials and methods
This project used a mixed methods approach to investigate women’s experiences of mistreatment during childbirth in general and informal coercion specifically: The present qualitative study expands on the findings from a nationwide online survey on childbirth experience. It combines inductive with theoretical thematic analysis to study the 7,753 comments women wrote in the survey and the subsequent interviews with 11 women who reported being mistreated during childbirth.

Results
The women described a wide range of experiences of mistreatment during childbirth in both the survey comments and the interviews. Out of all survey participants who wrote at least one comment (n = 3,547), 28% described one or more experiences of mistreatment. Six of the seven types of mistreatment listed in Bohren and colleagues’ typology of mistreatment during childbirth were found, the most frequent of which were ineffective communication and lack of informed consent. Five additional themes were identified in the interviews: Informal coercion, risk factors for mistreatment, consequences of mistreatment, examples of good care, and what’s needed to improve maternity care.

Conclusion
The findings from this study show that experiences of mistreatment are a reality in Swiss maternity care and give insight into women’s individual experiences as well as how these affect them during and after childbirth. This study emphasises the need to respect women’s autonomy in order to prevent mistreatment and empower women to actively participate in decisions. Both individual and systemic efforts are required to prevent mistreatment and guarantee respectful, dignified, and high-quality maternity care for all.
Research on Teaching Global Issues: Pedagogy for Global Citizenship Education, J. P. Myers (ed.) (2020)
Authors: Demir Vahap 
Published: February 2022

Review of: Research on Teaching Global Issues: Pedagogy for Global Citizenship Education, J. P. Myers (ed.) (2020)
Charlotte, NC: Information Age Publishing, 188 pp.,
ISBN 978-16-48020-51-3, p/bk, $45.99
Wizerunek Nikoli Tesli i jego wynalazków w grach cyfrowych
Authors: Kościelniak Jagoda 
Published: February 2022

Artykuł ten przybliża sposób przedstawiania Nikoli Tesli w grach cyfrowych, w których serbsko-amerykański wynalazca zyskuje coraz większą popularność. W dwunastu tytułach, w których się pojawia, określone i opisane zostały następujące kategorie jego cech: wygląd, miejsce pobytu, osobowość, rola, umiejętności, wynalazki i relacje z innymi, które razem składają się na wizerunek genialnego inżyniera.
Cardiomyocyte stromal interaction molecule 1 is a key regulator of Ca2+‐dependent kinase and phosphatase activity in the mouse heart
Authors: Collins Helen E. , Anderson Joshua C. , Wende Adam R. , Chatham John C. 
Published: February 2022

AbstractStromal interaction molecule 1 (STIM1) is a major regulator of store‐operated calcium entry in non‐excitable cells. Recent studies have suggested that STIM1 plays a role in pathological hypertrophy; however, the physiological role of STIM1 in the heart is not well understood. We have shown that mice with a cardiomyocyte deletion of STIM1 (crSTIM1−/−) develop ER stress, mitochondrial, and metabolic abnormalities, and dilated cardiomyopathy. However, the specific signaling pathways and kinases regulated by STIM1 are largely unknown. Therefore, we used a discovery‐based kinomics approach to identify kinases differentially regulated by STIM1. Twelve‐week male control and crSTIM1−/− mice were injected with saline or phenylephrine (PE, 15 mg/kg, s.c, 15 min), and hearts obtained for analysis of the Serine/threonine kinome. Primary analysis was performed using BioNavigator 6.0 (PamGene), using scoring from the Kinexus PhosphoNET database and GeneGo network modeling, and confirmed using standard immunoblotting. Kinomics revealed significantly lower PKG and protein kinase C (PKC) signaling in the hearts of the crSTIM1−/− in comparison to control hearts, confirmed by immunoblotting for the calcium‐dependent PKC isoform PKCα and its downstream target MARCKS. Similar reductions in crSTIM1−/− hearts were found for the kinases: MEK1/2, AMPK, and PDPK1, and in the activity of the Ca2+‐dependent phosphatase, calcineurin. Electrocardiogram analysis also revealed that crSTIM1−/− mice have significantly lower HR and prolonged QT interval. In conclusion, we have shown several calcium‐dependent kinases and phosphatases are regulated by STIM1 in the adult mouse heart. This has important implications in understanding how STIM1 contributes to the regulation of cardiac physiology and pathophysiology.
Classification and occurrence of an abnormal breathing pattern during cardiopulmonary exercise testing in subjects with persistent symptoms following COVID‐19 disease
Authors: von Gruenewaldt Anna , Nylander Eva , Hedman Kristofer 
Published: February 2022

AbstractReduced exercise capacity and several limiting symptoms during exercise have been reported following severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. From clinical observations, we hypothesized that an abnormal breathing pattern (BrP) during exercise may be common in these patients and related to reduced exercise capacity. We aimed to (a) evaluate a method to classify the BrP as normal/abnormal or borderline in terms of inter‐rater agreement; (b) determine the occurrence of an abnormal BrP in patients with post‐COVID; and (c) compare characteristics of post‐COVID patients with normal and abnormal BrP. In a retrospective, cross‐sectional study of patients referred for CPET due to post‐COVID April 2020–April 2021, we selected subjects without a history of intensive care and with available medical records. Three raters independently categorized patients’ BrP as normal, abnormal, or borderline, using four traditional CPET plots (respiratory exchange ratio, tidal volume over ventilation, ventilatory equivalent for oxygen, and ventilation over time). Out of 20 patients (11 male), 10 were categorized as having a normal, 7 an abnormal, and three a borderline BrP. Inter‐rater agreement was good (Fleiss’ kappa: 0.66 [0.66–0.67]). Subjects with an abnormal BrP had lower peak ventilation, lower exercise capacity, similar ventilatory efficiency and a similar level of dyspnea at peak exercise, as did subjects with a normal BrP. Patients’ BrP was possible to classify with good agreement between observers. A third of patients had an abnormal BrP, associated with lower exercise capacity, which could possibly explain exercise related symptoms in some patients with post‐COVID syndrome.
Variance of the number of cycles of random A-permutation
Authors: Yakymiv Arsen L. 
Published: February 2022

Abstract
We consider random permutations having uniform distribution on the set of all permutations of the n-element set with lengths of cycles belonging to a fixed set A (so-called A-permutations). For some class of sets A the asymptotic formula for the variance of the number of cycles of such permutations is obtained.
Too much of a good thing? Households’ macroeconomic conditions and credit dynamics
Authors: Hodula Martin , Malovaná Simona , Frait Jan 
Published: February 2022

Abstract
Favorable macroeconomic conditions, accompanied by optimistic consumer confidence, can stimulate and shape households’ expectations in such a way that they gradually extrapolate the view of good times lasting “forever”. As a consequence, households can then be inclined to accept a much higher level of indebtedness – higher than they would be willing to take on if they were to correctly perceive a discontinuation of the positive trend in the future. This paper documents the empirical link between the macroeconomic conditions faced by households, the confidence of households as investors and consumers, and households’ demand for credit on a sample of 21 European countries. The well-known procyclicality of household credit is found to grow stronger when favorable macroeconomic conditions are met with optimistic consumer confidence. While household credit goes hand in hand with the improving economy during an economic upturn, it is found to be sticky on the way down. Estimates show that households tend to extrapolate recent and current macroeconomic trends to the future and over-estimate the persistence of favorable or adverse conditions.
Parental leave in medical school: supporting students as parents
Authors: Ortega Sheila R. , Barnes Jacob M. , Waller Jacquelyn D. 
Published: February 2022

Abstract

Context
The overlap between medical school, residency, and childbearing potential increases the likelihood a woman will pursue parenthood within her, or her partner’s, medical training. Parental leave benefits mothers, fathers, and infants. Adequate parental leave promotes physical recovery, mental health, infant bonding, improved breastfeeding, appropriate childhood immunization, and familial engagement. Despite the risks and benefits, the United States does not have national paid maternity, paternity, or parental leave requirements. Complicating matters for medical trainees, parental leave policies are not well-defined within the undergraduate (UME) and graduate medical education (GME) realms. Significant policy advancements are on the horizon for GME; however, medical schools are left without evidence to support policy formation.

Objectives
This study aims to identify the presence and nature of maternal/paternal leave policies and procedures within UME. Given the authors’ close association with osteopathic medical education, only osteopathic medical schools were considered to lay the framework for future study in UME.

Methods
Investigators searched university websites for student handbooks outlining rules and policies surrounding parental leave. The following terms were utilized to investigate these documents: “parental,” “maternity,” “paternity,” “pregnant,” “pregnancy,” and “leave of absence” (LOA). Administrative personnel were contacted, and subjective data were documented. A parental leave policy was defined as explicitly dedicated to expectant parents or those parents planning on adoption. Medical leave or other short- and long-term LOA policies were not considered a parental leave policy.

Results
A total of 42 osteopathic medical schools were identified. Investigators established email communication with 17 schools (40.5%). Neither a student handbook nor email contact could be made with one institution. Two (4.9%) osteopathic medical schools overtly described parental leave in their policies. The majority of schools recommended students seeking parental leave follow short- or long-term LOA policies.

Conclusions
Without protected leave time, students must decide whether to begin a family or delay medical education. As GME begins prioritizing policy change, the authors call on UME to follow suit. Parenthood and medicine must be intertwined.
Dynamic millimeter-wave OAM beam generation through programmable metasurface
Authors: Bai Xudong , Zhang Fuli , Sun Li , Cao Anjie , He Chong , Zhang Jin , Zhu Weiren 
Published: February 2022

Abstract
Millimeter-wave (mmWave) and orbital angular momentum (OAM) multiplexing are two key technologies for modern wireless communications, where significant efforts have been devoted to combining these two technologies for extremely high channel capacities. Recently, programmable metasurfaces have been extensively studied for stimulating dynamic multi-mode OAM beams, owing to their ability of subtle dynamic modulation over electromagnetic waves in a digital manner. However, programmable metasurfaces for mmWave OAM stimulation are rarely mentioned, due to the requirement of extremely high processing precision for mmWave applications. In this paper, a programmable metasurface is presented to stimulate dynamic multi-mode mmWave vortex beams. The proposed metasurface is composed of electronically reconfigurable units, which is obtained through configuration integration of a PIN diode within each radiation patch for modulating the unit resonant property. Both low reflection losses and stabilized inverse phase states are obtained for the binary unit coding states within the operation band. Through modulating the real-time coding distribution on the metasurface by programmable bias circuit, the generation of mmWave OAM beams with mode numbers l = 0, l = +1, l = +2, and l = +3 are numerically designed and experimentally verified. Our study paves a new perspective for the cross amalgamation of both mmWave and multi-mode OAM technologies.
Association of intraoperative gross hematuria with acute kidney injury after cytoreductive surgery
Authors: Mitani Yumi , Arai Yohei , Tomohiro Mitani  , Gohda Yoshimasa , Yano Hideaki , Kondo Isao , Sakamoto Emi , Katagiri Daisuke , Hinoshita Fumihiko 
Published: February 2022

Abstract

Objectives
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has been established in the management of peritoneal carcinomatosis. Although it is still necessary to take adequate measures against major postoperative complications including acute kidney injury (AKI), consensus is lacking on how to assess and stratify risk for patients with postoperative AKI after CRS-HIPEC. The aim of this retrospective cohort study was to investigate the association of intraoperative gross hematuria as a surrogate marker of ureter injury with postoperative AKI incidence.

Methods
This retrospective cohort study investigated patients without impaired preoperative kidney function who underwent CRS-HIPEC at a single referral center, and evaluated the relationship between intraoperative gross hematuria and incidence of postoperative AKI as defined by the Kidney Disease Improving Global Outcomes practice guidelines. Logistic regression analysis was performed to calculate the odds ratio of intraoperative gross hematuria for AKI, adjusting for confounding factors and other risk factors for AKI.

Results
We enrolled 185 patients (males, 37%). Twenty-five patients developed intraoperative gross hematuria. Postoperative AKI occurred in 10 (40%) of 25 patients with hematuria and 28 (17.5%) of 160 patients without hematuria. The crude odds ratio for exposure to hematuria was 3.14 (95% confidence interval, 1.30–7.60; p=0.020) for postoperative AKI. Adjusted odds ratio as estimated by multivariate logistic regression was 4.57 (95% confidence interval, 1.55–13.45; p=0.006).

Conclusions
Intraoperative gross hematuria is significantly associated with postoperative AKI incidence after CRS-HIPEC.