bluuebunny/crossref_metadata_2025_split huggingface dataset:
An effective algorithm to detect the possibility of being MSI phenotype in endometrial cancer given the BMI status and histological subtype: a statistical study
Authors: González Villa Isabel , González Dávila Enrique Francisco , Afonso Idaira Jael Expósito , Blanco Leynis Isabel Martínez , Ferrer Juan Francisco Loro , Galván Juan José Cabrera 
Published: May 2022

Abstract
Purpose
In endometrial cancer, the incidence of mutations in mismatch repair genes (MMR) is estimated at 17–30%. Patients with alterations at this level (MSI) are known to have different clinical and anatomopathological characteristics than those without this genetic alteration (MSS). In this study, we aim to identify the MSI phenotype in patients who underwent hysterectomy for endometrial cancer. We assessed the correlation of this phenotype with anatomoclinical parameters such as obesity and histological subtype.

Methods/patients
Clinical and anatomopathological data were collected from 147 patients diagnosed with endometrial cancer and an immunohistochemical study of MMR system proteins was performed. PMS2 and MSH6 proteins were evaluated as primary screening and subsequent evaluation of MLH1 and MSH6, respectively, if the former were negative. Statistical association between the anatomopathological data and the immunohistochemical result was analyzed.

Results and conclusions
22.4% of our patients were MSI phenotype. We obtained statistically significant differences by multivariate analysis between endometrioid subtype and higher FIGO classification grade with MSI phenotype and obesity with MSS phenotype. Given these statistical results, we propose a function for predicting the probability of being MSI phenotype taking into account the histological subtype (endometrioid/non-endometrioid carcinoma) and FIGO grade as well as obesity. This prediction may be useful prior to hysterectomy, for genetic study of the MLH1 promoter and subsequent genetic counseling.
The Death of the Monograph?
Authors: Shaw Philip , Phillips Angus , Gutiérrez Maria Bajo 
Published: May 2022

AbstractA survey of English language academic publishers in the UK, Europe and North America was undertaken in 2021. The objective was to gather data on the current landscape of academic monograph publishing in the arts, humanities, and social sciences and to identify trends. Respondents were asked about their monograph publishing activities, sales, distribution, and about the future direction of their programmes. The paper offers independent analysis of publisher information that may be helpful in informing the debate among stakeholders as to the future of the publication of long-form research in the arts, humanities and social sciences. The results offer key insights into the growth in output of titles, the level of print sales, the move towards open access, usage of monographs, and their pricing.
Sustainment Rates and Factors for Multidimensional Family Therapy in Europe and North America
Authors: Dakof Gayle A. , Ricardo Mia M. , Rowe Cynthia , Henderson Craig , Rigter Henk , Liddle Howard A. 
Published: May 2022

AbstractThis retrospective non-experimental study examined the short-term (2-year) and longer-term (5-year and 8-year) sustainment of 137 programs in Europe and North America implementing a single evidence-based practice (EBP), Multidimensional Family Therapy (MDFT). MDFT implementation and sustainment is based on the Stages of Implementation (SIC) model outlined by Saldana and colleagues. The study had two primary objectives: (1) to examine short-term and longer-term sustainment rates of MDFT in Europe and North America, and (2) to explore potential factors that may be associated with sustainment of MDFT in particular, and the potential implications for behavioral health EBPs more generally. Results show that 90% of MDFT programs were sustained for at least 2 years, 87% of the programs sustained for at least 5 years, and 70% for at least 8 years. These findings compare favorably with the previous research on implementing and sustaining evidence-based practices. The findings support the growing consensus that not only start-up funding but also ongoing financing either through governments or third-party payors may be essential for longer-term sustainability of EBPs in both Europe and North America. This study also highlights the potential value of multi-site program networks. Future research directions are suggested, such as examination of the potential importance of the quality and nature of the EBP itself, adaptability to different organizations and clients, and providing high-quality structured and empowering training and quality assurance to sustain evidence-based behavioral health interventions. These programmatic and clinician-level factors are critical areas for further investigation into the sustainment of EBPs.
ON -ALGEBRAS WHICH DETECT NUCLEARITY
Authors: POP FLORIN 
Published: May 2022

AbstractA
$C^{*}$
-algebra A is said to detect nuclearity if, whenever a
$C^{*}$
-algebra B satisfies
$A\otimes _{\mathrm{min}} B = A\otimes _{\mathrm{max}} B,$
it follows that B is nuclear. In this note, we survey the main results associated with this topic and present the background and tools necessary for proving the main results. In particular, we show that the
$C^{*}$
-algebra
$A = C^{*}(\mathbb {F}_{\infty })\otimes _{\mathrm{min}} B(\ell ^{2})/K(\ell ^{2})$
detects nuclearity. This result is known to experts, but has never appeared in the literature.
OSCILLATION OF IMPULSIVE LINEAR DIFFERENTIAL EQUATIONS WITH DISCONTINUOUS SOLUTIONS
Authors: DOĞRU AKGÖL SIBEL 
Published: May 2022

AbstractSufficient conditions are obtained for the oscillation of a general form of a linear second-order differential equation with discontinuous solutions. The innovations are that the impulse effects are in mixed form and the results obtained are applicable even if the impulses are small. The novelty of the results is demonstrated by presenting an example of an oscillating equation to which previous oscillation theorems fail to apply.
Food security and diet quality in a racially diverse cohort of postpartum women in the USA
Authors: Hudak Katelin M. , Gonzalez-Nahm Sarah , Liu Tiange , Benjamin-Neelon Sara E. 
Published: May 2022

AbstractFood insecurity has been associated with poor diet, but few studies focused on the postpartum period – an important time for women’s health. We examined associations between food security and diet quality in postpartum women and assessed whether participation in federal food assistance programmes modified this potential relation. Using longitudinal data, we analysed the association between food security at 3 months postpartum and a modified Alternate Healthy Eating Index-2010 (AHEI) at 6 months postpartum (excluding alcohol). We conducted multivariable linear regressions examining associations between food security and AHEI. We assessed two food assistance programmes as potential effect modifiers. The sample included 363 postpartum women from the Nurture study, located in the Southeastern USA (2013–2017). Among women, 64·4 % were Black and 45·7 % had a high school diploma or less. We found no evidence of an interaction between food security and two federal food assistance programmes. In adjusted models, marginal, low and very low food security were not associated with AHEI. However, low (β: −0·64; 95 % CI −1·15, −0·13; P = 0·01) and very low (β: −0·57; 95 % CI −1·02, −0·13; P = 0·01) food security were associated with greater trans fat intake. Food security status was not associated with overall diet quality but was associated with higher trans fat (low and very low) and more moderate alcohol (marginal) intake. Future studies should assess the consistency and generalisability of these findings.
What factors drive gender differences in the body mass index? Evidence from Turkish adults
Authors: Caglayan-Akay Ebru , Ertok-Onurlu Merve , Komuryakan Fulden 
Published: May 2022

AbstractIn recent years, studies show that obesity has become an important health condition, especially among adults. The first aim of this study is to examine socio-demographic and behavioural factors on body mass index distribution of male and female adults over 20 years old in Turkey. The second aim is to determine the body mass index disparity by gender and the socio-demographic and behavioural factors that might wider or narrow it. This study adopts unconditional quantile regression and decomposition methods, and the data set covers the Turkish Health Surveys for 2014, 2016, and 2019. The findings document that high level of body mass index are associated with being married, aging, and physical inactivity. Interestingly, employment status has different contributions on the body mass index of males and females. The results also claim a body mass index gap among males and females as a result of differences in some potential socio-demographic and behavioural factors, and the gap gets higher at the upper and lower quantiles of BMI distribution. This study may provide a clear understanding for policymakers on how to design efficacious obesity policies considering the differences in the effect of socio-demographic and behavioural factors on the distribution of body mass index across females and males. The results suggest that the Ministry of Health should specifically target different groups for males and females and should reduce the differences in socio-demographic and behavioural determinants between females and males to prevent and reduce obesity prevalence in Turkey.
Medialisation laryngoplasty with bone wax in a sheep model
Authors: Nachalon Y , Cates D J , Nativ-Zeltzer N , Belafsky P C 
Published: May 2022

AbstractObjectiveTo evaluate the safety and biocompatibility of bone wax as an implant material for medialisation laryngoplasty in a large animal model.MethodsThree Dorper-cross ewes underwent type I thyroplasty of the right vocal fold with bone wax. The animals were monitored for four weeks for general wellbeing. The animals were euthanised and the larynges harvested. Histological evaluation was performed to assess for adverse tissue reaction and biocompatibility.ResultsThe mean (± standard deviation) amount of bone wax implanted was 0.49 g (± 0.12 g). No adverse events were reported. Ex vivo vibration was present on high-speed imaging for all medialised vocal folds. Histology demonstrated implanted paraffin embedded within the thyroarytenoid muscle with no evidence of resorption, a minimal inflammatory infiltrate, and a thin fibrotic capsule.ConclusionThe results of this investigation suggest that bone wax may be a safe and efficacious implant material for medialisation laryngoplasty. Further studies are necessary to assess its long-term safety and efficacy.
Efficacy and safety/tolerability of antipsychotics in the treatment of adult patients with major depressive disorder: a systematic review and meta-analysis
Authors: Kishimoto Taishiro , Hagi Katsuhiko , Kurokawa Shunya , Kane John M. , Correll Christoph U. 
Published: May 2022

AbstractBackgroundAntipsychotics are widely used in the treatment of major depressive disorder (MDD), but there has been no comprehensive meta-analytic assessment that examined their use as monotherapy and adjunctive therapy.MethodsA systematic review and a meta-analysis were conducted on randomized placebo-controlled trials (RCTs) that reported on the efficacy and safety/tolerability of antipsychotics for the treatment of adults with MDD. Data of both monotherapy and adjunctive antipsychotic use were extracted, but analyzed separately using a random-effects model. Co-primary outcomes were study-defined-treatment response and intolerability-related discontinuation. We also illustrated the risk/benefit balance of antipsychotics for MDD, using two-dimensional graphs representing the primary efficacy and safety/tolerability outcome. Secondary outcomes included psychopathology, remission, all-cause-discontinuation, inefficacy-related discontinuation, and adverse events.ResultsForty-five RCTs with 12 724 patients were included in the analysis. In monotherapy (studies = 13, n = 4375), amisulpride [1.99 (1.55–2.55)], sulpiride [1.50 (1.03–2.17)], and quetiapine [1.48 (1.23–1.78)] were significantly superior to placebo regarding treatment response. However, intolerability-related discontinuations were significantly higher compared to placebo with amisulpride and quetiapine. In adjunctive therapy (studies = 32, n = 8349), ziprasidone [1.80 (1.07–3.04)], risperidone [1.59 (1.19–2.14)], aripiprazole [1.54 (1.35–1.76)], brexpiprazole [1.41 (1.21–1.66)], cariprazine [1.27 (1.07–1.52)], and quetiapine [1.23 (1.08–1.41)] were significantly superior to placebo regarding treatment response. However, of these antipsychotics that were superior to placebo, only risperidone was equivalent to placebo regarding discontinuation due to intolerability, while the other antipsychotics were inferior.ConclusionResults suggest that there are significant differences regarding the risk/benefit ratio among antipsychotics for MDD, which should inform clinical care.
Solomon, his temple, and Ottoman imperial anxieties
Authors: Grenier Carlos 
Published: May 2022

AbstractSeveral works focusing on the complex figure of Solomon appeared between 1450 and 1580, each offering variations on the themes of empire-building, sedentarization, sacral kingship, and technological change.The Dürr-i Meknun, written around the time of the conquest of Constantinople, uses Solomon to illustrate the risks of urbanization, imperial hubris and potential tyranny. The second, the Süleyman-name by the technically inclined author Uzun Firdevsi, portrays Solomon in the image of Sultan Bayezid II. The prophet, using his bureaucratic capacities, enacts Ottoman dreams of control over the eastern Mediterranean. Finally, the accounts given of the deeds of Sultan Süleyman, notably the reconstruction of the Temple Mount and the construction of the Süleymaniye complex in Istanbul, show the Solomonic myth consciously enacted by the state itself. These sources trace a trajectory whereby anxieties surrounding the transformations of early modernity are expressed and worked through by means of the vocabulary of a prophetological sacred history.
Safety of drug-eluting stents for stenting patent arterial duct in neonates
Authors: Kurup Harikrishnan K.N. , Gopalakrishnan Arun , Sasikumar Deepa , Krishnamoorthy Kavassery M. 
Published: May 2022

AbstractObjectives:The primary objective was to evaluate the trend of blood sirolimus concentrations in neonates following ductal stenting. The long-term outcomes and incidence of infections were also evaluated.Methods:Prospective open-label observational study in a tertiary referral centre over a 1-year period. Serum sirolimus levels were estimated at 1 hour and 24hrs post-stent insertion followed by 7 days in neonates who underwent ductal stenting. The trend in sirolimus levels, incidence of infections, complications and outcomes following ductal stenting were studied.Results:Seven neonates with duct-dependent pulmonary circulation underwent ductal stenting at median age of 8.5 days and weight of 2.83kg. The average stent size was 3.5±0.4 mm, and average stent length was 16.3±5.1 mm. The mean sirolimus concentrations at 1 hour, 24 hours and 7 days were 41.3±6.9ng/ml, 15.4±7.1ng/ml and 3.1±0.85ng/ml respectively. Levels fell below therapeutic range for all patients by 7 days. Three patients had sepsis or necrotising enterocolitis, but responded well to antibiotics; 1 patient had aspiration related sudden death. There were no further events at a mean follow-up of 207 days, and 4 patients underwent elective surgery at 238 ± 81 days after ductal stenting.Conclusions:This study demonstrates applicability of drug-eluting stents for ductal stenting in newborns. Drug-eluting stents with abluminal drug delivery are associated with high sirolimus levels in initial hours but rapidly taper to negligible levels within a week of implantation. Neonates with high pre-procedure likelihood of infection developed sepsis but responded well to conservative management. The patency of drug-eluting ductal stents is preserved over long-term follow-up.
Paediatric cardiologist adherence to American Heart Association neurodevelopmental recommendations for CHD patients
Authors: Sidhu Sharnendra K. , McLaughlin Laura J. , Pham Tammy B. , Lazarevic Bojan , Kriegel Elana R. , Rosenthal Hannah E. , Rabinowitz Edon J. , Milanaik Ruth L. 
Published: May 2022

AbstractA 2012 American Heart Association statement concluded that children with CHD are at an increased risk for neurodevelopmental delays. Routine surveillance and evaluation throughout childhood are recommended. To assess paediatric cardiologist compliance with American Heart Association guidelines and developmental referral practices, a survey was distributed to paediatric cardiologists nationwide (n = 129). The majority of participants (69%) stated they were somewhat familiar or not familiar with the American Heart Association statement and were concerned about patients not being properly referred to specialists for developmental evaluation. Forty paediatric cardiologists (31%) indicated that their institution did not have a neurodevelopmental cardiology programme. Of these, 25% indicated they generally did not refer CHD patients for neurodevelopmental evaluation, 45% performed surveillance and referred if warranted, and 30% generally referred all patients for surveillance. Lastly, 43% of paediatric cardiologists did not feel responsible for developmental surveillance, and 11% did not feel responsible for referrals. To ensure all children with CHD are appropriately screened and referred, paediatricians and cardiologists must work together to address differing impressions of accountability for surveillance and screening of children with CHD.
Partially open stent after balloon catheter iatrogenic perforation. How to solve this complication using a novel technique? The Mij-Her technique
Authors: Mijangos-Vázquez Roberto , Hernández-Reyes Rogelio 
Published: May 2022

AbstractComplications related to pulmonary artery stenting are potentially life-threatening. We reported a novel technique of how to achieve the introduction of a partial dilated stent into a long sheath using a snare in the event of a iatrogenic perforation of a balloon catheter.There are no publications of similar techniques describing successful resolution of this type of complication.
Network leadership for transformative capacity development: roles, practices and challenges
Authors: Strasser Tim , de Kraker Joop , Kemp René 
Published: May 2022

Non-technical summary
A wide variety of social innovations exist today that offer urgently needed pathways for transforming societal systems into more just, sustainable and regenerative ways of organising human existence on this planet. However, a more systematic and practically useful understanding is needed of how individuals and organisations can strengthen the transformative capacity of people working on connecting, spreading, maturing and structurally embedding these innovations. This study presents an updated conceptual framework of network leadership roles and practices, and describes how these can contribute to more widespread, systemic and lasting impact of social innovations.

Technical summary
This study tests and refines a conceptual framework, describing the roles and practices of network leadership that can support the development of transformative capacities, in the context of social innovation networks. Such capacities include spreading social innovations in wider society, embedding them in policy and public discourse, and generating continuity and further development of social innovation activities. We studied five cases of transnational social innovation networks involving community-led and student-led sustainability initiatives. Practitioners in these networks were asked to rate and comment on the perceived recognisability and importance of network leadership roles and practices, as well as challenges, which we articulated in a previous study and further developed in the current study through participant observation and document analyses. This resulted in a revision of the roles and practices, the identification of relations between roles and a better understanding of how they can contribute to transformative capacity development. The interviews also helped to clarify the practical usefulness of the framework, suggesting possible applications for evaluating, prioritising and aligning roles performed by various individuals and organisations. The findings are relevant for better understanding and guiding distributed agency in transformative social innovation networks.

Social media summary
Roles and practices for network leadership to enable more widespread, systemic and lasting impact of social innovation.
Higher Resting Cardiovagal Activity Predicts Larger Decrease of Depressive Symptoms in Inpatients Treated for Stress-Related Depression
Authors: La Marca Roberto , Pallich Gianandrea , Holtforth Martin grosse , Hochstrasser Barbara 
Published: May 2022

Abstract. Depression is one of the most prevalent mental disorders, with treatment outcomes generally being unsatisfactory. The identification of outcome predictors could contribute to improving diagnosis, treatment, and outcome. Heart rate variability (HRV), an index of cardiovagal activity, has been proposed as a potential correlate of depression as well as a predictor of treatment effectiveness. The aim of the present study was to examine if HRV at baseline could predict the outcome of inpatient treatment for stress-related depressive disorder (SRDD). Depressive symptoms of n = 57 inpatients with an SRDD, who were treated in a specialized burnout ward, were assessed using the Beck Depression Inventory (BDI) at the beginning, the end of treatment, and at 3-month follow-up. HRV (i.e., RMSSD, the root mean square of successive RR interval differences) was determined from a five-minute measurement in the supine position. RMSSD was not significantly associated with the BDI score at the beginning, end, and follow-up. Higher RMSSD was revealed to be a significant predictor of a stronger decrease in depressive severity from the beginning to the end of the treatment. Thereby, the regression model explained 7.6% of the total variance in the BDI decrease. The results revealed initial HRV to predict a larger decrease in depressive severity. Therefore, resting HRV represents a physiological resource and index of successful neurovisceral interaction, which supports inpatients in benefitting from specialized treatment.
Sub‐Volcanic Structure Beneath Marius Hills, Moon, Inferred From Vent Distribution
Authors: Cañón‐Tapia Edgardo , Jacobo‐Bojorquez Rocío A. 
Published: May 2022

AbstractThe lunar region of Marius Hills has been interpreted as either a shield volcano or a volcanic complex lacking a central zone of magma accumulation at depth. The magmatic structure beneath Marius Hills inferred from gravity anomalies suggests the presence of dyke groups within the upper 20 km of lunar crust. However, the difference in character between the north and south free‐air anomalies remains enigmatic. In this work, we study the surface distribution of volcanic vents as an alternative method to obtain information concerning the magmatic structure beneath Marius Hills. A robust identification of independent groups of vents is made using several clustering methods, therefore avoiding possible biases associated with the particular form of analysis. The obtained results confirm the presence of the zones of magma accumulation inferred from gravity analysis but also serve to delineate in more detail the structure of the underlying plumbing system. Furthermore, the joint interpretation of the gravity, topography, and vent distribution analysis indicates that although Marius Hills should not be considered as a fully developed shield volcano as Mauna Kea on Earth, it shares some aspects of other terrestrial large shields where crustal differences (in thickness, lithology, presence of faults, etc.) exert a strong influence on the distribution of vents at the surface.