bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination against all odds? A story from Waste4Change
Authors: Adhariani Desi , Dewi Miranti Kartika 
Published: November 2022

Learning outcomes
This case aims to help students achieve the following learning objectives: ■ to apply the Emergence of Social Enterprise in Europe (Emergence des Enterprises Sociales en Europe – EMES) Network definitional framework to the case, and in doing so, have a useful framework to define social enterprises in emerging markets; ■ to identify the factors that can play important role in making strategic decisions in social enterprises; ■ to evaluate the sustainability of a social enterprise; and ■ to address the unique funding and financial challenges faced by social enterprises.

Case overview/synopsis
This case study discusses the dilemmas related to business expansion faced by Waste4Change (W4C), a waste management organization based in Bekasi, Jakarta, Indonesia. W4C was founded in 2014 by a group of young men who shared the idealism of changing the world by doing the right things. This principally involved protecting the environment and educating communities while maintaining economic profitability. However, idealism can sometimes create dilemmas within decision-making as an organization attempts to prevent market logic from dictating its direction. This case examines two different types of decision: the problem of securing a waste management contract when a permit had not been granted by the local government; and the problem of selecting the appropriate funding sources to enable the organization to grow. The first decision occurred in the context of a dilemma in 2017 when W4C expanded their waste management services to several regions in Indonesia but without having succeeded in securing a permit from the local government to provide such services. Attempts to provide such services without a formal legal permit would have been considered a violation of the law, even though the clients needed them (be it residents or companies) and the nature of the service in question had a positive connotation (i.e. maintaining the cleanliness of the city through waste management).The second decision concerned W4C’s plan to go public around 10 years from now. The CEO, Mohamad Bijaksana Junerosano, also known as Sano, has been considering this option since 2020 in a bid to grow the social enterprise. W4C differed from other startups; however, in the sense that while many startups will approach a plan to go public as an exit strategy, Sano wanted to preserve the idealism that had been a cornerstone of the enterprise since its inception. In other words, for W4C, going public was not just a means to an end.

Complexity academic level
Undergraduate as well as graduate courses that focus on sustainability, accounting, financing and strategy.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 1: Accounting and Finance.
Status and determinants of poverty among women-owned micro-businesses in Wolaita zone, southern Ethiopia
Authors: Ergo Alemayehu Elda , Connor Deirdre O’ , Mega Tekle Leza 
Published: November 2022

Purpose
Micro-businesses contribute to economic development by improving individual welfare. Women are the primary drivers and owners of such businesses in urban Ethiopia. The purpose of this study is to investigate the poverty status and determinants among women-owned micro-businesses.

Design/methodology/approach
The basic study units were women who owned micro-businesses. A sample of 384 women-owned micro-business was chosen using a stratified and systematic random sampling technique. Thirty-six participants were purposely chosen for in-depth interviews and focus group discussions. Questionnaires, in-depth interviews and focus group discussions were used to collect data. The poverty head count, poverty gap and poverty severity indices were computed to estimate poverty status. The major determinants of women’s poverty were investigated using a logistic regression model.

Findings
The overall poverty incidence, gap and severity were estimated to be 24.27%, 3.85%, and 1.11% respectively, among the women who owned micro-businesses. Eight of the 14 poverty determinants, including age, dependents, savings, remittance and the number of days and hours women work in their businesses, were found to have a significant effect on women’s poverty. The results suggest that local governments, technical and vocational training institutions should work together to reduce the impact of poverty-aggravating factors on women and increase the contribution of women-owned micro-businesses to poverty reduction.

Originality/value
This study addressed the poverty status of women who run micro-businesses, which is a crucial issue in Ethiopia’s urban context. It adds new knowledge to the issue of gendered economic participation, poverty reduction and poverty determinants in the Ethiopian context.
Biogeographical patterns of abundant and rare bacterial biospheres in paddy soils across East Asia
Authors: Luan Lu , Shi Guangping , Zhu Guofan , Zheng Jie , Fan Jianbo , Dini‐Andreote Francisco , Sun Bo , Jiang Yuji 
Published: November 2022

AbstractSoil bacterial communities play fundamental roles in ecosystem functioning and often display a skewed distribution of abundant and rare taxa. So far, relatively little is known about the biogeographical patterns and mechanisms structuring the assembly of abundant and rare biospheres of soil bacterial communities. Here, we studied the geographical distribution of different bacterial sub‐communities by examining the relative influence of environmental selection and dispersal limitation on taxa distributions in paddy soils across East Asia. Our results indicated that the geographical patterns of four different bacterial sub‐communities consistently displayed significant distance–decay relationships (DDRs). In addition, we found niche breadth and dispersal rates to significantly explain differences in community assembly of abundant and rare taxa, directly affecting the strength of DDRs. While conditionally rare and abundant taxa displayed the strongest DDR due to higher environmental filtering and dispersal limitation, moderate taxa sub‐communities had the weakest DDR due to greater environmental tolerance and dispersal rate. Random forest models indicated that soil pH (9.13%–49.78%) and average annual air temperature (16.59%–46.49%) were the most important predictors of the variation in the bacterial community. This study advances our understanding of the intrinsic links between fundamental ecological processes and microbial biogeographical patterns in paddy soils.
The impacts of price insulation on world wheat markets during the 2022 food price crisis
Authors: Martin Will , Minot Nicholas 
Published: November 2022

AbstractThis paper begins with a survey of recent commodity price developments that highlights the magnitude of this price surge and identifies the rapid rise in wheat prices as a key element. The analysis in this paper focuses on the extent to which domestic markets are insulated from these changes and on the resulting impacts on world prices. An econometric analysis using error‐correction models finds stable long‐term relationships between world wheat prices and most domestic prices of wheat and wheat products, but with considerable variation across countries in the rate of price transmission. A case study of the price shocks during the COVID‐19 pandemic and the Ukraine food price crisis finds that price insulation roughly doubled the overall increase in world wheat prices and raised their volatility both during periods of price increase and price decline.
Real‐world data for the renal safety of abemaciclib combined with bisphosphonate in HR+/HER2− advanced breast cancer
Authors: Hao Chunfang , Bai Xuedong , Zhang Jie , Meng Wenjing , Tong Zhongsheng 
Published: November 2022

AbstractObjectiveOur study evaluated the renal safety of abemaciclib plus endocrine therapy (ET) with bisphosphonate as a treatment option for hormone receptor positive, human epidermal growth factor receptor 2 (HER‐2) negative (HR+/HER2−) advanced breast cancer (ABC), especially with bone metastasis.MethodsData were collected from HR+/HER2− ABC patients who received abemaciclib with ET between March 2021 and May 2022 in a single medical center in China. We performed an analysis of the change in serum creatine (Cr) and creatine clearance (CrCl), time to first abnormal Cr value, and Common Terminology Criteria for Adverse Events grade of increased creatinine.ResultsA total of 210 patients were included in the final analysis, with a median age of 56 years and a median weight of 65 kg. Any grade laboratory‐assessing increased Cr occurred in 87.1% of patients, while CrCl rarely went down to 30 ml/min. Associations between start dose with grade of increased Cr and menopausal status with alert value, which is defined as creatinine clearance <30 ml/min, were indicated.ConclusionThis study shows that abemaciclib combined with bisphosphonate would be safe for renal function in HR+/HER2− ABC patients with bone metastases.
Malondialdehyde acetaldehyde adduction of surfactant protein D attenuates SARS‐CoV‐2 spike protein binding and virus neutralization
Authors: Muralidharan Abenaya , Bauer Christopher , Katafiasz Dawn M. , Pham Danielle , Oyewole Opeoluwa O. , Morwitzer M. Jane , Roy Enakshi , Bailey Kristina L. , Reid St Patrick , Wyatt Todd A. 
Published: November 2022

AbstractBackgroundOver 43% of the world's population regularly consumes alcohol. Although not commonly known, alcohol can have a significant impact on the respiratory environment. Living in the time of the COVID‐19 pandemic, alcohol misuse can have a particularly deleterious effect on SARS‐CoV‐2‐infected individuals and, in turn, the overall healthcare system. Patients with alcohol use disorders have higher odds of COVID‐19‐associated hospitalization and mortality. Even though the detrimental role of alcohol on COVID‐19 outcomes has been established, the underlying mechanisms are yet to be fully understood. Alcohol misuse has been shown to induce oxidative damage in the lungs through the production of reactive aldehydes such as malondialdehyde and acetaldehyde (MAA). MAA can then form adducts with proteins, altering their structure and function. One such protein is surfactant protein D (SPD), which plays an important role in innate immunity against pathogens.Methods and ResultsIn this study, we examined whether MAA adduction of SPD (SPD‐MAA) attenuates the ability of SPD to bind SARS‐CoV‐2 spike protein, reversing SPD‐mediated virus neutralization. Using ELISA, we show that SPD‐MAA is unable to competitively bind spike protein and prevent ACE2 receptor binding. Similarly, SPD‐MAA fails to inhibit entry of wild‐type SARS‐CoV‐2 virus into Calu‐3 cells, a lung epithelial cell line, as well as ciliated primary human bronchial epithelial cells isolated from healthy individuals.ConclusionsOverall, MAA adduction of SPD, a consequence of alcohol overconsumption, represents one mechanism of compromised lung innate defense against SARS‐CoV‐2, highlighting a possible mechanism underlying COVID‐19 severity and related mortality in patients who misuse alcohol.
Readability, reliability and credibility of online patient information on skin grafts
Authors: Heaven Chelsea L. , Patel Cheerag , Ahmadi Omid , Mathy Jon A. 
Published: November 2022

AbstractBackgroundSkin grafting reflects a common dermatological procedure for closing skin defects. Patient education is important for managing expectation and optimising skin graft take. While health information is increasingly accessed on the internet, there are no existing studies assessing their quality.MethodsThe first 25 results from Google, Microsoft Bing and Yahoo! search engines using the term ‘skin graft’ were analysed using a variety of standard instruments. Readability was assessed using the Flesch–Kincaid Grade score (FKG), Gunning Fog Index (GFI), Simple Measure of Gobbledygook (SMOG) and the New Dale‐Chall Readability Index (NDC). Reliability was assessed using the DISCERN instrument and credibility with the Journal of the American Medical Association Benchmark Criteria (JAMA). Transparency was identified by presence of the Health On the Net Foundation Code certification (HON‐code).ResultsSeventy‐five websites were identified. After exclusion, forty‐three remaining websites were analysed with average FKG, GFI and SMOG scores of 7.8, 10.1 and 10.7, respectively. The average NDC was 5.9. The average reliability was fair with a DISCERN score based on the first 15 questions of the instrument of 42.6. The mean JAMA score was 2, and 9 websites displayed the HON‐code certificate.ConclusionsReadability, reliability and credibility of online health information regarding skin grafting can be improved. Health care providers should critically assess existing online patient information or develop alternative material to educate patients undergoing skin graft surgery.
Application of CT contrast medium is not associated with an increased risk for acute kidney injury in patients with decompensated cirrhosis
Authors: Tergast Tammo L. , Schulte Benjamin , Griemsmann Marie , Kahlhöfer Julia , Dörge Petra , Hinrichs Jan B. , Kraft Anke R. M. , Schmidt Julius J. , Behrendt Patrick , Wedemeyer Heiner , Cornberg Markus , Maasoumy Benjamin 
Published: November 2022

SummaryBackgroundAcute kidney injury (AKI) is a frequent complication in patients with decompensated cirrhosis. Studies reported conflicting results regarding the nephrotoxic potential of iodinated contrast medium (CM) for computer tomography (CT).AimTo investigate the impact of diagnostic CM application on kidney function in patients with decompensated cirrhosis.MethodsFirst, we evaluated the impact of diagnostic CM‐CT on AKI incidence in a cross‐sectional approach. Second, we analysed 28‐day AKI incidence post‐CM‐CT in patients with impaired kidney function (i.e., creatinine >133 μmoL/L). Third, we excluded all patients with relevant interventions besides CM‐CT. All remaining patients were matched via propensity score matching (PPSM) and further analysed. Last, we validated the results in an independent dataset of prospectively collected registry data of 118 patients with decompensated cirrhosis. Here, plasma samples were analysed regarding neutrophil‐gelatinase‐associated‐lipocalin (NGAL).ResultsOf the 611 included patients, 98 (16%) received CM‐CT. CM‐CT was not associated with AKI in the cross‐sectional approach (CM‐CT:8% vs. no CM‐CT:15%; p = 0.08). Furthermore, CM‐CT was not associated with higher 28‐day AKI incidence among patients with impaired kidney function (HR:0.79; 95% CI 0.45–1.38; p = 0.40). The PPSM cohort revealed no association between CM‐CT and AKI or severe AKI (HR:1.28, p = 0.45 and HR:1.62; p = 0.43). Moreover, CM‐CT did not result in worsening of kidney function after CM application. In the validation cohort, CM‐CT was also not linked to AKI (p = 0.85) and NGAL levels were not increased in those with CM‐CT (CM‐CT:309 ng/ml vs. No CM‐CT:266 ng/ml, p = 0.35).ConclusionDecompensated cirrhosis per se should not preclude diagnostic CM‐CT.
Safety of coronavirus disease 2019 vaccines in 213 adult patients with sickle cell disease
Authors: Joseph Laure , Corbasson Anne , Manceau Sandra , Khimoud Djamal , Meunier Benoit , Cheminet Geoffrey , Lefrere François , Jannot Anne‐Sophie , Lu Estelle , Arlet Jean‐Benoît 
Published: November 2022

SummaryGiven the lack of information about safety of the COVID‐19 vaccines for sickle cell disease (SCD) patients, we sought to determine whether COVID‐19 vaccine was associated with subsequent hospital admission for vaso‐occlusive events (VOEs). We included 402 patients with SCD, including 88 regularly transfused. As of July 31, 2021, 213 (53.0%) of them had received a least one dose of COVID vaccine (Pfizer 93.0%). We showed similar risk of hospital admission for a VOE among vaccinated patients (whether transfused or not) and among a control group of non‐vaccinated patients matched for age, sex and genotype.
Severe aortic regurgitation from aortic valve perforation in Libman‐Sacks endocarditis: Incremental value of 3D TEE
Authors: Adil Amina , Kazmi Faraz N. , Malik Ijaz A. , Ammar Khawaja Afzal 
Published: November 2022

AbstractA 43‐year‐old woman with stroke and systemic lupus erythematosus was found to have severe eccentric aortic regurgitation. Three‐dimensional transesophageal echocardiogram further defined the origin of the regurgitant jet through a perforation in the left coronary cusp next to a mass with a tiny stalk attached to the left coronary cusp.
Multiple‐attribute decision‐making spherical vague normal operators and their applications for the selection of farmers
Authors: Palanikumar Murugan , Arulmozhi Krishnan , Jana Chiranjibe , Pal Madhumangal 
Published: November 2022

AbstractIn this article, we discuss a few fresh approaches to the spherical vague normal set (SVNS) approach to multiple attribute decision‐making (MADM) problems. A new generalization of the vague set (VS) and the spherical interval valued fuzzy set (SIVFS) is the spherical vague set (SVS). The spherical vague number (SVN) concepts consolidate normal fuzzy number (NFN) and we defined the spherical vague normal number (SVNN) and some of its intriguing fundamental operations. The purpose of this article is to discuss a novel idea of spherical vague normal weighted averaging (SVNWA), spherical vague normal weighted geometric (SVNWG), generalized spherical vague normal weighted averaging (GSVNWA) and generalized spherical vague normal weighted geometric (GSVNWG) operators. We talked about a flowchart with an algorithm that uses this operators and the MADM approach. With the help of a numerical example, we interact the extended euclidean and hamming distance measures. In this communication, it is also important to elaborate on some key SVN approach characteristics based on various algebraic operations, such as idempotency, boundedness, commutativity, and monotonicity. They are quicker to find the best option, more straightforward and practical. Think about five farmers. The four factors that are taken into account for each of the five farmers are climate, water, soil, disease, and flood, and their corresponding weights are displayed. We want to select the best option from a large number of choices by comparing expert assessments with the criteria. As a result, the conclusions of the defined models are more precise and closely related to . We contrast some of the current models with the ones that have been proposed in order to demonstrate the dependability and utility of the models under investigation. The study's findings are also intriguing and fascinating.
High‐intensity ultrasound reduces fermentation time and improves textural properties, antioxidant activity and probiotic survival in fermented probiotic strawberry drink
Authors: Mizuta Amanda G. , de Menezes Jéssica L. , da Silva Luciana A. , Marcolino Vanessa A. , Barão Carlos E. , Pimentel Tatiana C. , de Abreu Filho Benício A. , Madrona Grasiele S. 
Published: November 2022

SummaryThis study aimed to evaluate the effect of high‐intensity ultrasound (HIUS) application with different processing times (2.5, 5, 7.5 and 10 min) on the physicochemical, rheological and textural properties, antioxidant activity (AA) and probiotic survival in strawberry‐flavoured fermented probiotic strawberry drink during storage (7°C for 28 days). The application of HIUS resulted in products with lower fermentation times, higher organic acid stability during storage and improved texture (higher firmness and consistency) and functional properties (higher phenolic compounds content and/or AA). Using 2.5 min of processing time would be advisable due to the better probiotic survival to simulated gastrointestinal conditions (probiotic counts higher than 106 CFU mL−1), reduced fermentation times (reduction in 3 h), higher lactic acid content during storage and enhanced AA. The products showed a viable probiotic counts higher than 106 CFU mL−1 during the entire shelf life. HIUS may be considered as an adequate pre‐treatment in the development of probiotic fermented probiotic strawberry drink.
Antifungal features and properties of Pickering emulsion coating from alginate/lemongrass oil/cellulose nanofibers
Authors: Wardana Ata Aditya , Wigati Laras Putri , Van Tran Thi , Tanaka Fumina , Tanaka Fumihiko 
Published: November 2022

SummaryThis study investigated the antifungal features of sodium alginate (Alg) 1% combined with lemongrass essential oil (LGO) 0.25%, 0.5% and 0.75% as a Pickering emulsion coating to control Penicillium digitatum and P. italicum, identified as citrus fruit pathogens. Cellulose nanofibers 0.24%, 42.55 ± 9.34 nm, were selected as a stabiliser. Confocal laser scanning microscopy and Fourier‐transform infrared spectroscopy were used to analyse the droplet size and morphology and chemical interaction of emulsified coating, respectively. The effective dosage of lemongrass oil (0.75%) may enhance the antifungal action confirmed with a series of in vitro tests on spore germination by 88.28% (P. digitatum) and 91.94% (P. italicum), germ tube elongation by 89.28% (P. digitatum) and 90.13% (P. italicum) and membrane integrity by 41.67% (P. digitatum) and 63% (P. italicum). Additionally, the incorporation of LGO Pickering emulsion improved the beneficial properties of Alg‐based coating film, including light transmission at UV and visible light wavelengths and hydrophobicity. Scanning electron microscopy was performed to evaluate the interior microstructure of the coating film. Pickering emulsion‐based coatings described in this study may have potential applications for active packaging, particularly for citrus fruit commodities.
Inhibition of NLRP3 inflammasome activity by MCC950 leads to exacerbation of Sjӧgren's syndrome pathologies in non‐obese diabetic mice
Authors: Zhou Jing , Onodera Shoko , Yu Qing 
Published: November 2022

AbstractSjӧgren's syndrome (SS) is an autoimmune inflammatory disease characterized by chronic inflammation and dysfunction of exocrine glands and causes dry mouth, dry eyes and various systemic health problems. The objective of this study is to define the in vivo actions of the endogenous NLRP3 inflammasome, a key initiator and mediator of various immune and inflammatory conditions, in newly established SS disease. MCC950, a highly specific small‐molecule inhibitor of NLRP3 inflammasome formation and activation, was intraperitoneally administered to the female non‐obese diabetic (NOD) mice aged 11 weeks, which have newly established SS‐like hyposalivation and pathologies. The injection was conducted three times weekly for three consecutive weeks and mice were analysed for characteristic SS pathologies at the end of the treatments. MCC950 treatment resulted in a marked reduction in salivary secretion and an exacerbation of leukocyte infiltration of submandibular glands. The disease‐worsening effect of MCC950 treatment was accompanied by increased T and B cell numbers, enhanced T helper 1 response and reduced aquaporin 5 expression in submandibular glands. Hence, ablation of endogenous NLRP3 inflammasome activity by MCC950 with established autoimmune exocrinopathy exacerbates salivary gland dysfunction and inflammation, indicating a disease‐alleviating and inflammation‐dampening action of the endogenous NLRP3 inflammasome activity during established SS disease in the non‐obese diabetic mouse model.