bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient optimization and development of two methods for the determination of acrylamide in deep‐frying oil by liquid chromatography–tandem mass spectrometry: Application of multifactor analysis assessment strategy
Authors: Zhang Yanxia , Zhao Huinan , Sun Shanshan , Lu Lanxiang , Xue Xia , Su Shufang , Gong Pixue , Zheng Wenjing , Wang Mingdong , Wang Jun , Zhu Jianhua , Liu Yanming , Zhang Feng 
Published: November 2022

A new multifactor analysis assessment strategy was developed for evaluating, optimizing, and comparing analytical techniques for acrylamide in frying oils. Based on five indices (absolute recovery, absolute matrix effect, the intensity of the full ion scan, and the precursor ion scan to m/z 184 and m/z 241), the proposed strategy was performed with radar analysis, relative contribution analysis, and the entropy‐weighted technique for order performance by similarity to ideal solution analysis. Two novel methods based on quick, easy, cheap, effective, rugged, and safe extraction methodology and gel permeation chromatography–liquid–liquid extraction followed by liquid chromatography–tandem mass spectrometry have been developed for the analysis of acrylamide in frying oils. Two methods were suitable for rapid and sensitive analysis of acrylamide in oils in different laboratories, with a limit of quantitation at 2 μg/kg, and the average recovery ranging from 92.5% to 107.8%, with relative standard deviations below 10%. When considering automation efficiency and matrix effects, gel permeation chromatography is the most efficient method, whereas the other method has an advantage when analyzing large samples. The developed methods were used in a pilot study to analyze frying oils with acrylamide content below 9.82 μg/kg, showing that the repeated frying process did not produce significant content of acrylamide in oils.
Cyclophanediene and Cyclophanetriene‐Based Conjugated Polymers
Authors: Mann Arielle , Hannigan Matthew D. , Weck Marcus 
Published: November 2022

AbstractPoly(p‐phenylene vinylene)s (PPVs) and poly(arylene vinylene)s are key materials for a variety of applications ranging from organic light emitting diodes to fluorescent optical probes. Their syntheses, however, have been hampered by non‐living or step‐growth polymerization techniques. The development of functional‐group tolerant olefin metathesis catalysts has enabled the use of living ring‐opening metathesis polymerization (ROMP) of cyclophane monomers yielding PPVs and poly(p‐phenylene‐co‐arylene vinylene)s in a living manner. Low dispersity and soluble PPVs are afforded with control over the number of repeat units with easy incorporation of different end‐groups at their heads or tails. In this review, a comprehensive overview of tetrasubstituted and disubstituted alkyl and alkoxy containing [2.2]paracyclophane‐1,9‐diene, [2.2]metaparacyclophane‐1,9‐diene, [2.2.2]paracyclophane‐1,9,17‐triene, and benzothiadiazole‐[2.2]paracyclophane‐1,9‐diene is provided. The high ring strain of these monomers enables efficient polymerizations with ruthenium initiators. A particular emphasis is on [2.2]paracyclophane‐1,9‐dienes as it is the most investigated class of polymerized cyclophanediene since initially reported 30 years ago. Additionally, applications for soft materials synthesized by ROMP are examined, highlighting easily accessed PPV copolymers and PPV block copolymers that can be phototriggered, as well as PPVs featuring supramolecular recognition units installed at their termini to afford orthogonally self‐assembled architectures.
Long‐Term Recording of Subthalamic Aperiodic Activities and Beta Bursts in Parkinson's Disease
Authors: Darmani Ghazaleh , Drummond Neil M. , Ramezanpour Hamidreza , Saha Utpal , Hoque Tasnuva , Udupa Kaviraja , Sarica Can , Zeng Ke , Cortez Grippe Talyta , Nankoo Jean‐Francois , Bergmann Til Ole , Hodaie Mojgan , Kalia Suneil K. , Lozano Andres M. , Hutchison William D. , Fasano Alfonso , Chen Robert 
Published: November 2022

ABSTRACTBackgroundLocal field potentials (LFPs) represent the summation of periodic (oscillations) and aperiodic (fractal) signals. Although previous studies showed changes in beta band oscillations and burst characteristics of the subthalamic nucleus (STN) in Parkinson's disease (PD), how aperiodic activity in the STN is related to PD pathophysiology is unknown.ObjectivesThe study aimed to characterize the long‐term effects of STN–deep brain stimulation (DBS) and dopaminergic medications on aperiodic activities and beta bursts.MethodsA total of 10 patients with PD participated in this longitudinal study. Simultaneous bilateral STN‐LFP recordings were conducted in six separate visits during a period of 18 months using the Activa PC + S device in the off and on dopaminergic medication states. We used irregular‐resampling auto‐spectral analysis to separate oscillations and aperiodic components (exponent and offset) in the power spectrum of STN‐LFP signals in beta band.ResultsOur results revealed a systematic increase in both the exponent and the offset of the aperiodic spectrum over 18 months following the DBS implantation, independent of the dopaminergic medication state of patients with PD. In contrast, beta burst durations and amplitudes were stable over time and were suppressed by dopaminergic medications.ConclusionsThese findings indicate that oscillations and aperiodic activities reflect at least partially distinct yet complementary neural mechanisms, which should be considered in the design of robust biomarkers to optimize adaptive DBS. Given the link between increased gamma‐aminobutyric acidergic (GABAergic) transmission and higher aperiodic activity, our findings suggest that long‐term STN‐DBS may relate to increased inhibition in the basal ganglia. © 2022 International Parkinson and Movement Disorder Society.
The use of plain radiography in diagnosing osteoarthritis: A systematic review and time trend analysis
Authors: Henry‐Blake Connor , Marshall Michelle , Treadwell Kane , Parmar Simran , Higgs Jordan , Edwards John J. , Peat George 
Published: November 2022

AbstractIntroductionThe National Institute for Health and Care Excellence (NICE) suggest there is no role for routine radiography in the diagnosis of osteoarthritis (OA). It is not known how consistent this recommendation is across international guidelines, or the impact of UK guidance on domestic OA X‐ray request rates.MethodsA systematic search identified guideline recommendations on the role of radiography in OA diagnosis. Full texts underwent dual screening and appraisal using the AGREE II tool. A narrative synthesis was performed. Consultation data were extracted from a UK primary care database: the Consultations in Primary Care Archives (CiPCA). The annual proportion of X‐ray requests per 100 OA consulters from 2000 to 2012 were calculated. Joinpoint regression analysis examined if there were changes in the trend of X‐ray request rates and compared these with the publication dates of UK guidelines.ResultsEighteen evidence‐based OA guidelines were included in the review. Eleven recommended a clinical diagnosis of OA without radiographic confirmation. Seven recommended routine radiography; these guidelines were predominantly for radiologists. A mean of 17.3 X‐rays per 100 patients were requested in patients consulting for OA per year between 2000 and 2012. A statistically significant reduction in X‐ray request rates was seen in 2003.ConclusionRecommendations on the role of radiography in OA vary between medical specialty and countries. UK guidelines appear to have had a limited impact on X‐ray request rates in OA.
Theoretical Models, Preparation, Characterization and Applications of Cyanine J‐Aggregates: A Minireview
Authors: Dar Nitzan , Ankari Rinat 
Published: November 2022

AbstractCyanines are one of the few kinds of molecules whose absorbance and emission can be shifted in a broad spectral range from the ultraviolet to the near infrared. They can easily transform into J‐aggregates with narrow absorption and emission peaks, along with a redshift in their spectra. This mini‐review presents cyanine dyes and their J‐aggregates and discusses their structure and spectral properties that illustrate their specificities. We summarize the theoretical and experimental state of the art on cyanine J‐aggregates and their applications, also laying the groundwork for cyanine J‐aggregates synthesis and characterization methods.
Ternary copolymers from carbon dioxide, cyclohexane dicarboxylic anhydride, and propylene oxide with improved thermal and mechanical properties
Authors: Li Qingshuo , Zhang Ji , Zhang Yudong , Su Yue , Duan Baogen , Li Xiaohong , Zhang Zhijun , Wang Hongxia , Chang Haibo , Lin Tong 
Published: November 2022

AbstractIn this study, for the first time, we used cyclohexane dicarboxylic anhydride (CH) as the third monomer to terpolymerize with carbon dioxide (CO2) and propylene oxide (PO) under the catalysis of zinc glutarate (ZnGA). Incorporating cis‐CH (C‐CH) and trans‐CH (T‐CH) into poly(propylene carbonate) (PPC) improved the thermal and mechanical properties and increased the polymer molecular weight and yield. T‐CH showed better improvement than C‐CH because of its twist‐chair form. PPC‐CH containing 3% T‐CH exhibits the glass transition temperature (Tg) and maximum weight thermal decomposition temperature (Tmax) at 38.6 and 263°C, respectively, and shows the Young's modulus and tensile strength about 2.9 GPa and 40.5 MPa, respectively, which has comparable mechanical properties to commercial poly(butylene succinate), polypropylene, and high‐density polyethylene. PPC‐CH may form a novel method to recover CO2 in the form of polymers for various applications.
Psychosocial functioning of parents of Dutch long‐term survivors of childhood cancer
Authors: van Gorp Marloes , Joosten Mala M. H. , Maas Anne , Drenth Babet L. , van der Aa–van Delden Alied , Kremer Leontien C. M. , van Dulmen‐den Broeder Eline , Tissing Wim J. E. , Loonen Jacqueline J. , van der Pal Helena J. H. , de Vries Andrica C. H. , van den Heuvel‐Eibrink Marry M. , Ronckers Cécile , Bresters Dorine , Louwerens Marloes , Neggers Sebastian J. C. C. M. , van der Heiden‐van der Loo Margriet , Maurice‐Stam Heleen , Grootenhuis Martha A. ,   Dutch LATER study group
Published: November 2022

AbstractObjectiveTo describe health‐related quality of life (HRQoL), post‐traumatic stress and post‐traumatic growth of parents of long‐term survivors of childhood cancer (CCS) and study associated factors.MethodsParents of survivors of the Dutch Childhood Cancer Survivor Study LATER cohort below 30 years and diagnosed 1986–2001 were invited to complete the TNO‐AZL Questionnaire for Adult's HRQoL (e.g., sleep and aggressive emotions), Self‐Rating Scale for Post‐traumatic Stress Disorder, Post‐traumatic Growth Inventory, and Illness Cognition Questionnaire. HRQoL domain scores were compared to references using Mann‐Whitney U tests. Correlations between post‐traumatic stress, growth and HRQoL were evaluated. Medical characteristics of their child and illness cognitions were studied as associated factors of HRQOL, post‐traumatic stress and growth. p < 0.05 was considered statistically significant.ResultsParents (n = 661 of n = 448 survivors, 56% female, mean time since child's diagnosis: 21.3 [SD: 3.3] years) reported better HRQoL in social functioning and aggressive emotions than references (r = .08–0.17). Mothers additionally reported better HRQoL in pain, daily activities, sexuality, vitality, positive and depressive emotions (r = .07–0.14). Post‐traumatic stress was symptomatic in 3%, and associated with worse HRQoL (r = −0.27–0.48). Post‐traumatic growth was positively associated to post‐traumatic stress and better HRQoL (r = 0.09–0.12). Cancer recurrence was associated to better HRQoL (β = 0.37–0.46). Acceptance illness cognitions were associated to better (β = 0.12–0.25), and helplessness to worse outcomes (β = 0.14–0.38).ConclusionsHRQoL of parents of young adult survivors of CCS is comparable to references or slightly better. Only a small proportion reports symptomatic post‐traumatic stress. Improving acceptance and reducing feelings of helplessness may provide treatment targets for parents with psychosocial problems.
Pannier is a key regulator of embryogenesis, pupal development and female reproduction in the insect pest Bactrocera dorsalis
Authors: Zhang Qiang , Dou Wei , He Li‐Qiang , Yu Shan‐Shan , Chen Jia‐Qing , Zheng Li‐Yuan , Wang Lin , Smagghe Guy , Wang Jin‐Jun 
Published: November 2022

AbstractBackgroundMost arthropods are famous for their large reproductive capacity, with the ovary playing a vital role in the process. The study of the regulatory mechanisms of ovarian development may have the potential for a reproduction‐based pest management strategy. GATA‐binding transcription factors (GATAs) as important regulatory factors mediate many physiological processes, including development, immunity, insecticide resistance and reproduction. The Pannier (pnr), a member of GATA family, was confirmed to be involved in ovarian development of Bactrocera dorsalis in our previous study. However, the direct evidence of pnr regulating the fly ovarian development is still lacking.ResultsWe used CRISPR/Cas9 to create Bdpnr loss‐of‐function mutations. Homozygous Bdpnr−/− mutants were nonviable, with most individuals dying during embryogenesis, some surviving to the larval stages, and the remaining few dying during pupation. In contrast, heterozygous individuals reached the adult stage, but ovarian development was disrupted, with concomitant decreases in egg laying and hatching rates. We also found that two genes encoding vitellogenin proteins (BdVg1 and BdVg2) and the vitellogenin receptor (BdVgR) were significantly down‐regulated in heterozygous mutants compared to wild‐type controls.ConclusionThese results indicate that Bdpnr is required for embryonic and post‐embryonic development, including the formation of ovaries. Bdpnr could therefore be considered as a molecular target for tephritid fly pest control. © 2022 Society of Chemical Industry.
Commercial human pulmonary artery endothelial cells have in‐vitro behavior that varies by sex
Authors: Cox‐Flaherty Katherine , Baird Grayson L. , Braza Julie , Guarino Brianna D. , Princiotto Amy , Ventetuolo Corey E. , Harrington Elizabeth O. 
Published: November 2022

AbstractIt is unknown whether biological sex influences phenotypes of commercially available human pulmonary artery endothelial cells (HPAECs). Ten lots of commercial HPAECs were used (Lonza Biologics; PromoCell). Five (50%) were confirmed to be genotypically male (SRY+) and five (50%) were confirmed to be female (SRY−). Experiments were conducted between passages five and eight. HPAEC phenotype was confirmed with a panel of cell expression markers. Standard assays for proliferation, migration and tube formation were performed in triplicate with technical replicates, under three treatment conditions (EndoGRO; Sigma‐Aldrich). Apoptosis was assessed by exposing cells treated with complete media or low serum media to hypoxic (1% oxygen) or normoxic (20% oxygen) conditions. Laboratory staff was blinded. The median (range) age of male and female donors from whom the HPAECs were derived was 58 (48–60) and 56 (33–67), respectively. Our results suggest decreased proliferation in genotypically female cells compared with male cells (p = 0.09). With increasing donor age, female cells were less proliferative and male cells were more proliferative (p = 0.001). Female cells were significantly more apoptotic than male cells by condition (p = 0.001). Female cells were significantly more migratory than male cells in complete media but less migratory than male cells under vascular endothelial growth factor enriched conditions (p = 0.001). There are subtle sex‐based differences in the behavior of HPAECs that depend on donor sex and, less so, age. These differences may undermine rigor and reproducibility. Future studies should define whether biological sex is an important regulator of HPAEC function in health and disease.
Structural stability, elasticity and minimum thermal conductivity of M‐doped Mg17Al12 (M = Ga, In, Ge, Sn, Pb) compounds: A first‐principles predictions
Authors: Sun Yuan , Yang Ancang , Duan Yonghua , Qi Huarong , Peng Mingjun , Shen Li 
Published: November 2022

AbstractIn this work, first‐principles calculations were used to study the structural, elastic and thermodynamic properties of Mg17Al12 and M‐doped Mg17Al12 (Mg16Al12M, M = Ga, In, Ge, Sn, Pb) compounds. The calculated results show that Mg16Al12M compounds have negative defect formation energies, the calculated phonon dispersions have no imaginary frequencies, and their single‐crystal elastic constants satisfy the mechanical stability criterion. Thus, Mg16Al12M compounds are thermodynamically, dynamically and mechanically stable. The calculated GH/BH, Poisson's ratio v and Cauchy pressure values indicate that Mg17Al12 and Mg16Al12M are ductile, the ductility of the doped system is greater than that of Mg17Al12. Mg17Al12 and Mg16Al12M have elastic anisotropy, and the order of anisotropy is Mg16Al12Sn > Mg16Al12Ga > Mg16Al12In > Mg17Al12 > Mg16Al12Ge > Mg16Al12Pb. Finally, the minimum thermal conductivities based on Clarke's and Cahill's models were discussed, and the results show the heat transfer rates of Mg17Al12 and Mg16Al12M along the [111] direction are faster than those along other directions.
Prescribed performance event‐triggered control for strict‐feedback switched nonlinear systems
Authors: Fan Zhida , Wang Fenglan , Long Lijun 
Published: November 2022

AbstractThis article is concerned with the problem of prescribed performance event‐triggered tracking control for a class of strict‐feedback switched uncertain nonlinear systems. A prescribed performance event‐triggered adaptive fuzzy control approach for solving the problem is set up by exploiting backstepping and the average dwell time (ADT) technique. Compared with the existing prescribed performance control designed in the continuous‐time context, the proposed approach constructs a prescribed performance event‐triggered adaptive fuzzy controller for each subsystem and a switching event‐triggered mechanism (ETM), which can largely save communication resources. Meanwhile, the issue of asynchronous switching between candidate subsystems and candidate controllers is dealt with, and transient and steady‐state performance of tracking error is ensured under a class of switching signals with ADT. Moreover, the result above is extended to switched uncertain nonlinear systems with vanishing control gains at some points by developing a hysteresis‐type switching signal. Also, Zeno phenomenon is excluded for the switching ETM and the hysteresis‐type switching signal. Finally, two examples are given to verify the effectiveness of the obtained two results, respectively.
Two‐Dimensional Nanofluidic Membranes with Intercalated In‐Plane Shortcuts for High‐Performance Blue Energy Harvesting
Authors: Yan Pan‐Ping , Chen Xia‐Chao , Liang Zi‐Xuan , Fang You‐Peng , Yao Juming , Lu Chun‐Xin , Cai Yurong , Jiang Lei 
Published: November 2022

AbstractTwo‐dimensional nanofluidic membranes offer great opportunities for developing efficient and robust devices for ionic/water‐nexus energy harvesting. However, low counterion concentration and long pathway through limited ionic flux restrict their output performance. Herein, it is demonstrated that rapid diffusion kinetics can be realized in two‐dimensional nanofluidic membranes by introducing in‐plane holes across nanosheets, which not only increase counterion concentration but also shorten pathway length through the membranes. Thus, the holey membranes exhibited an enhanced performance relative to the pristine ones in terms of osmotic energy conversion. In particular, a biomimetic multilayered membrane sequentially assembled from pristine and holey sections offers an optimized combination of selectivity and permeability, therefore generating a power density up to 6.78 W m−2 by mixing seawater and river water, superior to the majority of the state‐of‐the‐art lamellar nanofluidic membranes. This work highlights the importance of channel morphologies and presents a general strategy for effectively improving ion transport through lamellar membranes for high‐performance nanofluidic devices.
Liquid‐Metal‐Assisted Synthesis of Single‐Crystalline TiC Nanocubes with Exposed {100} Facets for Enhanced Electrocatalytic Activity in the Hydrogen Evolution Reaction
Authors: Jeong Kyoung‐Jin , Lee Yohan , Huynh Thanh‐Nam , Nersisyan Hayk , Suh Hoyoung , Lee JongHyeon 
Published: November 2022

AbstractAlthough TiC nanostructures show promise as non‐noble‐metal‐based electrocatalysts, improved synthesis methods are required. Herein, single‐crystalline TiC nanocubes with exposed {100} facets are grown by combusting TiO2 + kMg + C reactive mixtures (k = 4–6.5 mol) in argon. During the synthesis, the temperature increases to 1200–1550 °C and excess Mg (2–4.5 mol) forms a liquid pool. The obtained TiC nanocubes have edge lengths of 50–300 nm and surface areas of 12.2–30.05 m2 g−1. Insights into the TiC nanocube formation mechanism are obtained using density functional theory modeling of the surface energies of TiC nanocrystals and shape visualization using the Wulff construction method. During TiC nucleation and growth within the Mg melt, liquid Mg likely acts as a capping agent for {111} facets, thus promoting the formation of {100} facets. The TiC nanocubes show high electrocatalytic activity for the hydrogen evolution reaction, with a lower overpotential (0.298 V at 10 mA cm−2) than other TiC nanostructures (0.400–0.815 V).
Die sechs Subsidiary Governance Inhaltsmodule
Authors: Renz Patrick , Böhrer Nikola , Peter Marc K. 
Published: November 2022

ZusammenfassungDas Subsidiary Governance Modell besteht aus den sechs Inhaltsmodulen System, Mission, Integrität, Stakeholder, Risiko und Audit. System-Management beschäftigt sich mit dem ganzheitlichen Verständnis des Unternehmens, seiner Umwelt, der Anspruchsgruppen und des Kontexts. Die Kenntnis der Zusammenhänge innerhalb eines Systems (Strukturen, Prozesse, Abhängigkeiten, Rollen) und der Positionierung von Mutterhaus und Tochtergesellschaft intern und gegenüber der Umwelt ist entscheidend für eine zielorientierte Subsidiary Governance.
Mission Management befasst sich mit Strategie, Struktur und Kultur – Elemente, die Ordnung ins System Unternehmen bringen.
Integritätsmanagement beschäftigt sich mit den Werten guter Zusammenarbeit. Durch Bewusstseinsförderung und das Einrichten von Prozessen und Instrumenten können Compliance und ethisches Verhalten sichergestellt und Reputationsverluste vermieden werden. Stakeholdermanagement besteht aus Definition, Identifizierung, Management und Kontrolle der Stakeholder.
Risikomanagement beinhaltet den gesamten Risikomanagementprozess, von der Risikodefinition über die Bewertung der hierarchiestufengerechten Risiken bis hin zur Schulung spezifischer Risiken.
Audit Management beschäftigt sich sowohl mit den gesetzlichen Anforderungen als auch mit der Effektivität, Effizienz, Erfolgsrelevanz und Rolle interner und externer Audits.