bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review on quality of life (QoL) of patients with peritoneal metastasis (PM) who underwent pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Authors: Li Zhenyue , Wong Louis Choon Kit , Sultana Rehena , Lim Hui Jun , Tan Joey Wee-Shan , Tan Qiu Xuan , Wong Jolene Si Min , Chia Claramae Shulyn , Ong Chin-Ann Johnny 
Published: April 2022

Abstract

Background
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has recently emerged as a palliative alternative for patients with unresectable peritoneal metastasis (PM). Quality of life (QoL) has increasingly been used as an endpoint to evaluate treatment outcomes. This review aims to identify evidence on how PIPAC would impact the QoL of PM patients.

Content
A systematic review was performed on articles identified from Medline, EMBASE, PsycInfo, and Web of Sciences. A meta-analysis was conducted on further selected studies. ACROBAT-NRSI was attempted to assess the risk of bias (RoB).

Summary
Nine studies using the EORTC QLQ-C30 questionnaire to assess QoL after repeated PIPAC cycles were identified. Majority was found to be moderately biased and a great extent of heterogeneity was observed. Four studies on PM from either gastric cancer (GC) or epithelial ovarian cancer (EOC) were included for meta-analysis. In 31 GC patients and 104 EOC patients, QoL remained stable in 13/14 and 11/14 EORTC QLQ-C30 scales. PIPAC was inferior to cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) in global QoL and functioning but superior in symptom reduction.

Outlook
PIPAC is a well-tolerated option for most GC and EOC patients with irresectable PM. Future trials are warranted to confirm the findings.
An overview of activation cross-section measurements of some neutron and charged-particle induced reactions in Bangladesh
Authors: Uddin M. Shuza , Hossain Syed M. , Shariff M. Asad , Rakib-uz-Zaman M. 
Published: April 2022

Abstract
Over the last several decades, our research group has been working on nuclear data measurements using a J-25 Neutron Generator, a TRIGA Mark II Research Reactor and a Tandem Accelerator at Savar, as well as an Am/Be neutron source at Rajshahi. The spectrum of fast neutrons having energies from 0.5 to 20 MeV in the core of the TRIGA reactor as well as from 1.5 to 11 MeV of the Am/Be source was well characterized for validation of evaluated data of neutron threshold reactions. Spectrum-averaged cross sections were determined by integral measurements. The integral values measured at both the reactor and the Am/Be source were compared with the integrated data deduced from measured and evaluated excitation functions of some nuclear reactions given in some data libraries. As example, the details on the integral and integrated cross sections of the 64Zn(n,p)64Cu and 60Ni(n,p)60Co reactions are discussed. In both cases, integral test shows that further improvement of the evaluated excitation function reported in data libraries is needed. The use of a newly developed facility at the 3 MV Tandem Accelerator in measurement of proton induced reaction cross sections in the energy region below 5 MeV is outlined, and new results on the 64Ni(p,n)64Cu and natNi(p,x)61Cu processes below 3 MeV are discussed.
Special radionuclide production activities – recent developments at QST and throughout Japan
Authors: Nagatsu Kotaro , Ohya Tomoyuki , Obata Honoka , Suzuki Kazutoshi , Zhang Ming-Rong 
Published: April 2022

Abstract
National Institutes for Quantum Science and Technology (QST), formerly known as the National Institute of Radiological Sciences (NIRS), has been engaged in work on radiopharmaceutical science using cyclotrons since 1974. Eight pioneering researchers founded the basis of this field of research at NIRS, and to the present, many researchers and technicians have accumulated both scientific and technical achievements, as well as inherited the spirit of research. Besides, in recent years, we have developed production systems with AVF-930 cyclotron for various ‘non-standard’ radioisotopes applied in both diagnosis and therapy. Here, we review the past 50 years of our activities on radioisotope and radiopharmaceutical development, as well as more recent activities.
Processing of cell assemblies in the lateral entorhinal cortex
Authors: Traub Roger D. , Whittington Miles A. 
Published: April 2022

Abstract
There is evidence that olfactory cortex responds to its afferent input with the generation of cell assemblies: collections of principal neurons that fire together over a time scale of tens of ms. If such assemblies form an odor representation, then a fundamental question is how each assembly then induces neuronal activity in downstream structures. We have addressed this question in a detailed model of superficial layers of lateral entorhinal cortex, a recipient of input from olfactory cortex and olfactory bulb. Our results predict that the response of the fan cell subpopulation can be approximated by a relatively simple Boolean process, somewhat along the lines of the McCulloch/Pitts scheme; this is the case because of the sparsity of recurrent excitation amongst fan cells. However, because of recurrent excitatory connections between layer 2 and layer 3 pyramidal cells, synaptic and probably also gap junctional, the response of pyramidal cell subnetworks cannot be so approximated. Because of the highly structured anatomy of entorhinal output projections, our model suggests that downstream targets of entorhinal cortex (dentate gyrus, hippocampal CA3, CA1, piriform cortex, olfactory bulb) receive differentially processed information.
Discriminant properties of the Behavioral Pain Scale for assessment of procedural pain-related distress in ventilated children
Authors: Mauritz Maximilian David , Uhlenberg Felix , Dreier Larissa Alice , Giordano Vito , Deindl Philipp 
Published: April 2022

Abstract

Objectives
Children hospitalized in a pediatric intensive care unit (PICU) are frequently exposed to distressing and painful medical procedures and interventions. There is a lack of clinical scales to measure procedural pain-related distress in ventilated children. The Behavioral Pain Scale (BPS) was initially developed to detect procedural pain in critically ill adults. This study aims to assess the BPS’s discriminant properties for measuring procedural pain-related distress in ventilated pediatric patients incorporating two instruments validated for pediatric patients.

Methods
This prospective exploratory study was performed with ventilated children admitted to the interdisciplinary 14-bed PICU of the University Children’s Hospital, University Medical Center Hamburg-Eppendorf, Germany. The nurse in charge and an independent observer simultaneously assessed the patients using German versions of the BPS, the COMFORT-B scale (CBS), and the modified Face, Legs, Activity, Cry, Consolability (mFLACC) scale immediately before and during endotracheal suctioning.

Results
We analyzed 170 parallel assessments in n=34 ventilated children. Patients were (mean ± SD) 9.5 ± 4.8 years old. Internal consistency for the BPS was excellent (α=0.93). We found a high rater agreement for all clinical scales (BPS: k=0.73, CBS: k=0.80, mFLACC: k=0.71). Strong correlations were identified between BPS and CBS (r=0.89) and BPS and mFLACC (r=0.79). The BPS cutoff values showed likewise excellent results (area under the curve CBS >16: 0.97; mFLACC >2: 0.91).

Conclusions
In our population of ventilated children, the BPS was well suited to detect procedural pain-related distress compared with two validated pain scales. Further extensive validation studies should follow to support our findings.
Financial crisis spread, economic growth and unemployment: a mathematical model
Authors: Tadmon Calvin , Njike Tchaptchet Eric Rostand 
Published: April 2022

Abstract
The unemployment is the main channel through which the economic and financial crises influence the social development. In this paper, we propose a mathematical model to study the interactions between financial crisis spread, economic growth and unemployment. We also solve an optimal control problem focusing on the minimization, at the lowest cost, of the adverse effects of the financial crisis. The analysis of the model leads us to two equilibria: (1) a stress free equilibrium, where the economy and the employment are optimal, and (2) a stressed equilibrium. We obtain a theoretical confirmation of Okun’s law and a formula to compute the minimum reservation wage in terms of model parameters. Numerical simulations are performed to illustrate the theoretical results obtained.
O ativismo feminista online no Brasil
Authors: Facioli Lara Rodrigues , Gomes Simone da Silva Ribeiro 
Published: April 2022

O objetivo do artigo é analisar as relações entre os feminismos e as mídias digitais em um contexto de expansão do acesso à internet no Brasil. A partir dos desdobramentos ocorridos na última década, interessa-nos compreender como se constroem novos repertórios dos ativismos feministas nas redes digitais, com atenção às transformações sociotécnicas, tecnológicas e políticas. O material empírico resulta de duas pesquisas qualitativas, com entrevistas semiestruturadas, realizadas com ativistas feministas em Londrina e no Rio de Janeiro, combinadas com acompanhamento de interações em redes sociais. Os resultados apontam para uma (re)configuração da prática política em que a promessa do digital somada aos acontecimentos políticos posteriores às jornadas de junho de 2013 no Brasil, recompõem os diagramas e os repertórios políticos desses movimentos.
Democracia estancada
Authors: Costa Lara Denise Góes da 
Published: April 2022

Este artigo apresenta alguns aspectos das teorias de Foucault e Derrida como influentes nas teorias decoloniais e aponta que é possível “complementar” tais teorias com a justificação moral de que carecem. Neste sentido, recupera-se a teoria da redistribuição e do reconhecimento de Nancy Fraser como princípios de justiça social para as teorias decoloniais.
Calidad de fibra y producción de metano en ensilados de leguminosas con fuentes de carbohidratos
Authors: López-Herrera Michael , Arias-Gamboa Mauricio , Alpízar-Naranjo Andrés , Castillo-Umaña Miguel 
Published: April 2022

El objetivo de esta investigación fue determinar el efecto de la fuente de carbohidratos y la especie de leguminosa sobre la calidad de la fibra, producción de gas y la concentración de metano en ensilados. El experimento se realizó entre agosto 2015 y febrero 2016. Se utilizó un diseño factorial 4x4, con cuatro leguminosas (Vigna unguiculata, Arachis pintoi, Cratylia argentea, Erythrina poeppigiana) y 4 fuentes de carbohidratos (melaza de caña de azúcar, pulpa de cítricos deshidratada, maíz molido y guineo cuadrado [GC]). Se utilizaron microsilos, que fueron almacenados por 50 días y en la apertura se midieron los indicadores de interés. El análisis de la información se realizó por medio de modelos lineales y mixtos. Se determinó que en promedio las mezclas ensiladas con leguminosas arbustivas generaron mayor contenido de fibra, aunque de menor calidad, debido a un mayor contenido de lignina en comparación con los ensilados de leguminosas herbáceas. Por otra parte, el GC fue la fuente de carbohidratos que alteró la cantidad y calidad de la fibra en los ensilados, debido al mayor contenido de FDN y lignina del fruto. Estas variaciones en la calidad y cantidad de la fibra influenciaron la producción de gas (ml/gMS), mientras que la producción de metano (L/kgMS) en el gas fue afectada por la calidad de la fibra y el contenido de taninos condensados en el forraje. En conclusión, la especie y la fuente de carbohidratos generan diferencias en la cantidad y calidad de la fibra, lo que a su vez repercute sobre la producción de gas y concentración de metano de los ensilados de leguminosas. Es así como los ensilados de Arachis o Erythrina combinados con maíz fueron los de menor producción y concentración de metano.
Histological Alteration of Green Mussel Perna viridis Organs Exposed to Microplastics
Authors: Rahim Nur Fadhilah , Yaqin Khusnul 
Published: April 2022

Microplastic in the oceans might interfere the health of marine organisms, including the green mussels (Perna viridis). This is due to microplastic accumulation in mussels organs, such as gills, hepatopancreas, and gonads. Therefore, tissue alteration is a good indicator for ecological risk analysis and other ecotoxicological study activities. Green mussels with shells 4.1 to 5.0 cm in length were collected from Mandalle waters, Pangkep Regency (Pangkajene Islands), Indonesia. Green mussels were exposed for seven days to microplastic with concentrations of 0.05 (A), 0.5 (B), and 5 (C) g/L. The results showed that the higher the concentration of microplastics exposed to the green mussel, the higher the accumulation of microplastics in the body of the mussel, within the tested concentrations. The increased concentration of microplastics increased the level of tissue alteration in the gills, hepatopancreas, and gonads, with the most sensitive organ being the hepatopancreas. Overall, the study confirmed that the histological assay of mussel organs could be used as a biomarker in ecotoxicological studies.
Retinopatía diabética y edema macular diabético en población de Antioquia.
Authors: Bravo Juan David , Correa Alexandra , Bravo Andrés , Bravo Ricardo , Villada Oscar Alonso 
Published: April 2022

Introducción: la diabetes mellitus (DM) es una epidemia mundial. La retinopatía diabética proliferativa (RDP), el edema macular diabético (EMD) y las complicaciones de la diabetes mellitus son las principales causas de discapacidad visual y ceguera en los adultos en la edad productiva. Aproximadamente, 1 de cada 3 personas con DM tiene retinopatía diabética (RD) y 1 de cada 10 tiene RDP o EMD. En el presente estudio se hace énfasis en esta última, siendo el primero con estas características en Colombia.
Métodos: estudio transversal descriptivo donde se incluyeron 1.203 pacientes con diagnóstico de DM atendidos en la jornada “No más ciegos por Diabetes” del Hospital San Vicente Fundación de Medellín, en el 2017 y 2018. Se evaluó la presencia de RD y EMD clínico y sus características pidemiológicas en un análisis bivariado.
Resultados: del total de pacientes con DM tamizados (1.203), el 5,4 % (65) tenían EMD; dentro de estos, el 7,7 % tenía DM tipo 1 y el 89,2 % DM tipo 2. El 10,8 % tenía RDP, 73,8 % tenía RD no proliferativo (RDNP). En un 93,8 % se hizo diagnóstico de novo de RD. La mediana del tiempo de la diabetes fue de 14 años, con un rango intercuartílico (RIQ) entre 7 y 19,5. La mediana de la hemoglobina glicosilada (HbA1C) fue de 8,3 % (RIQ: 7,1-11). De 65 pacientes con EMD, 28 (56 ojos de los 130 con EMD) fueron estudiados con tomografía de coherencia óptica (OCT) y al 85,7 % se le confirmó EMD. La mediana del grosor macular central fue de 249 micras (RIQ: 231-341) en los pacientes con EMD por OCT (n = 48 ojos).
Conclusión: las complicaciones de la diabetes son más prevalentes en los pacientes con RD. La media del tiempo de aparición de EMD fue similar al tiempo de inicio de las complicaciones microvasculares de la diabetes reportada en la literatura, pero debe ser considerada en el contexto del control metabólico de los pacientes.
Enfermedad renal crónica de las comunidades agrícolas, una revisión de la literatura
Authors: Nieto-Ríos John Fredy , García-Prada Camilo Andrés , Vesga-Martín Daniel , Obregón-Giraldo Manuela , Serna-Higuita Lina María 
Published: April 2022

La enfermedad renal crónica (ERC) se define como la alteración funcional o estructural progresiva de los riñones que persiste por 3 meses o más. Esta enfermedad afecta el 10 al 15 % de la población mundial, siendo la diabetes mellitus, la hipertensión arterial, las glomerulopatías primarias y las enfermedades genéticas las etiologías más frecuentemente asociadas. Sin embargo, en los países pobres se reportan otras enfermedades ausantes de la ERC; entre ellas la nefropatía mesoamericana (NM). La NM se presenta principalmente en la población masculina joven, lo cual lleva a pérdida de la vida laboral productiva. En Colombia hay una alta prevalencia de ERC con etiología no estudiada (mal llamada desconocida) y hay pocas investigaciones de la ERC en las comunidades agrícolas. Teniendo en cuenta que la población campesina de Colombia se expone a noxas climáticas y laborales similares a Mesoamérica, es posible que esta nefropatía también sea una causa de ERC en nuestra población. El presente artículo hace una revisión de la ERC de las comunidades agrícolas, con el fin de sensibilizar el personal de salud en la importancia de la búsqueda de esta enfermedad en la población vulnerable, lo cual podría impactar de una forma positiva en la salud de los agricultores y campesinos.
Accidental Leaders: Experiences and Perspectives of Higher Education Leaders in Pakistan
Authors: Khwaja Tehmina , Zafar Aliya M , Faize Fayyaz Ahmad 
Published: April 2022

This research explored the experiences and perspectives of university leaders in Pakistan. Using a qualitative narrative approach, we explored leadership stories, challenges, and opportunities at various positions unique to the Pakistani context. Findings underscored the accidental nature of higher education leadership in Pakistan, the significance of mentoring provided by teachers and family support for nascent academic leaders, as well as the challenges these academic leaders face ranging from financial barriers to teaching quality issues, to retention of foreign qualified faculty. The research offers several policy recommendations including institutionalized leadership training and support for promising leaders; transparency in policies regarding leader appointment, promotion, and succession; support for existing universities rather than expansion; and addressing brain drain due to the attrition of foreign qualified faculty members.
Trust and Media: Reflection of the Big Five Factor Personality Traits on COVID-19 Pandemic Communication
Authors: GÖKALİLER Ebru , ALİKILIÇ Özlem , ALİKILIÇ İnanç 
Published: April 2022

The pandemic process, in general, is a process that creates anxiety due to reasons such as confusion, instability, misinformation and inadequate planning. Within the scope of this study, the assumption that the personality traits of individuals are effective in getting information and taking the required measures while carrying out the health communication during COVID-19 pandemic, and from the question of whether the individual differences can be associated with the inclination for information receipt or not. This scope of this study aims to measure how the communication of the COVID-19 epidemic towards the Turkish people affects the individuals’ preferences for information, the relationships between the sources they trust, and their individual differences based on the Big-5 factors, within the framework of the five major personality traits. This quantitative study, firstly aims to investigate the information-seeking behavior of the Turkish public in relation to their perceptions of COVID-19 and the impact of messages received from the media. Secondly, it is aimed to measure how the COVID-19 pandemic communication affects the relationships among the media sources they trust in their choices of information. While the trust in health care professionals and independent health care associatons were the highest among the individuals who participated in the survey, those who have the responsibility personality trait, trust in the content of COVID-19 messages for government agencies is low.
Preprocessing Factors Affected Free Fatty Acid Content in Crude Palm Oil Quality
Authors: Edyson Edyson , Murgianto Fitrah , Ardiyanto Adhy , Astuti Erika Juli , Ahmad Melina Putri 
Published: April 2022

The quality of CPO (Crude Palm Oil) is determined by the Free Fatty Acid (FFA) with the standard value below 5%. High FFA in CPO will cause further difficulties due to low refining rate and quality like rancidness and odor. The objective of this research was to determine the factors that affect the FFA content in CPO. This research was conducted from January until April 2021. Fruit samples were collected from BKLE and PNRE East Kotawaringin and analyzed to Analytical Laboratory PT BGA. The FFA value was determined using the titration method according to Indonesian National Standard (SNI). Based on this research, several factors such as rat and moth attacks, fruit maturity, fruit handling, and delayed delivery to the palm oil mill affected the FFA value. These factors caused an increase in the FFA value up to 41.10%‒204% compared to the average FFA value is only 0.77%‒1.29%. Therefore, minimizing the pre‐processing problem will reduce the potential of FFA value increment so that good quality CPO can be obtained.

Keywords: fruit handling, fruit maturity, pest attack, titration method
Kajian Penerapan Teknologi Pengendalian Penyakit pada Pembibitan Sengon di Bogor
Authors: Arif Ravi Wibowo  , Suryo Wiyono  , Anna Fariyanti  
Published: April 2022

Sengon (Falcataria moluccana) cultivations still have to face threats from plant diseases. Diseases can be found in nurseries and plantation. Biological agents can be used to control various types of plant diseases and have various advantages. The use of biological agents in forestry plantations must consider the aspects of effectiveness and efficiency. This study aims to examine the effect of various treatment of control technology packages on the incidence of major diseases, and to determine the financial feasibility of various disease control technology packages for sengon in nurseries. The research was conducted through interviews to explore cultivation techniques and production costs. In addition, experiments were carried out on the application of various disease control strategies using commercial formulations of biological agents. The commercial formulations of biological agents used were Rhizomax, Primagrain, Trichowish, Kayabio, Bio-Hara Plus, and fungicide Dithane M-45 80 WP. There were two treatment packages of new technology that have an effect on increasing the growth of sengon at the beginning of growth stage, namely P1 (BioHara Plus and KayaBio) and P2 (Rhizomax and Primagrain) treatments. All treatments of the new technology package had no significant effect on increasing the survival rate and suppressing the incidence and severity of disease in sengon seedlings. All new technology package treatments can generate profits even though the value is smaller when compared to existing technology treatments. All the new technology package treatments have an R/C ratio of more than 1 so that they are feasible to be applied by farmers. Keywords: biological control, feasibility, plant diseases, nurseries, Falcataria moluccana