bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-Situ Pore Plugging Using Nanosilica-Based Fluid System for Gas Shutoff to Maximize Oil Production
Authors: Karadkar Prasad , Almohsin Ayman , Bataweel Mohammed , Huang Jin 
Published: October 2022

Summary
A nanosilica (NS)-based fluid system was evaluated for forming in-situ glass-like material inside the matrix for permanent gas shutoff. The innovative aspect of this technique is how it turns NS into a substance that resembles glass-like material to block pores. This method involves two steps: First is pumping low-viscosity aqueous NS mixture into the formation and allowing it to gel up. Second is allowing gas production to dehydrate the NS gel to form in-situ glass-like material inside the formation. In this paper, an NS-based fluid system was assessed for pumping strategy and performance evaluation. An NS-based fluid system consists of a mixture of colloidal silica and activators. It possesses low viscosity, which assists in deeper penetration during placement. With time and temperature, it can lead to in-situ gelation to form a rigid gel to block the pore space. The NS-based fluid system was optimized using gelation tests and coreflooding tests to evaluate its performance under high-pressure, high-temperature conditions. The formation of in-situ glass-like material inside pores was analyzed using a scanning electron microscope (SEM).
The gelation time can be tailored by varying the activator type and concentration to match the field operation requirements. Kinetics of colloidal silica gelation at elevated temperatures showed faster viscosity buildup as compared to a lower temperature. Before gelation, the viscosity for the NS-based fluid system was recorded as less than 5 cp at a 10 s–1 shear rate, whereas after gelation, the viscosity was increased to more than 500 cp at a 10 s–1 shear rate. Using coreflooding tests, N2 gas permeability of the Berea sandstone core was completely plugged after pumping the five times pore volume (PV) of NS-based fluid system at 200°F. During NS-based fluid system injection through the core, differential pressure was increased to only 10 psi showing better injectivity than viscous polymeric gel. The SEM images showed the presence of glass-like material filling the porosity, which showed an in-situ generation of glass-like material inside pores. After the successful placement of NS-based fluid system in one of the gas wells having sandstone formation, gas production was reduced by 65%. Polymeric fluids systems are viscous in nature, and difficult to pump deeper inside the formation, also with time, polymers tend to degrade making ineffective shutoff treatment over a period. The NS-based fluid system presented in this paper is robust, thermally stable, environmentally friendly, and can serve as an alternative to currently used conformance polymers for gas shutoff applications.
Characteristic of Spiral Displacement Process in Primary Cementing of Vertical Well Washout
Authors: Zhang Zhuangzhuang , Huang Zhongwei , Zhou Yisu , Sheng Mao , Wu Bangchen 
Published: October 2022

Summary
Cementation is an essential process in well drilling, which provides security and isolation for following operations and for wells’ long-life production. Irregularity of the wellbore makes cementing more complex, with displaced fluid becoming easily trapped and leading to poor isolation. Here, we investigated spiral displacement of washout, which is one kind of irregularity, where the spiral flow is induced by a cyclone centralizer. The features of spiral flow with sudden hole enlargement, differences between spiral and nonspiral displacement processes, and influence of some parameters were investigated with a simulation method. First, the induced radial flow is around zero (10−1) of the main flow, which is enough for displacing radially, and this radial flow results in radial migration and dispersion of flow field. Cooperating with reversing flow after hitting the outer wall, radial migration leads to flow field mixing and spiral velocity dissipating quickly along the axial direction. Moreover, spiral flow is beneficial for cementing of washout, and the displacing pattern with spiral flow is different compared with axis flow. In spiral displacement, cement slurry accumulates at the bottom and outer side of the washout, while accumulation happens at the top and inner side of the washout for nonspiral flow. The accumulation pattern in spiral displacement prompts movement of residual fluid, but topside accumulation hinders removal of that. Of these parameters, density difference can depress the elongation of the interface and has a positive effect on displacement. An increase in washout length and diameter has a favorable influence, as such enlargement allows for further development of displacing flow and delays the breakthrough. An increase in displacing velocity and rotation angle has a nonmonotonic effect in that with the displacing velocity increasing, the displacement first worsens, then improves, but increasing the rotation angle has the opposite effect.
Effect of Amla Fruit (Phyllanthus emblica) Extract in Flow Assurance of Indian Waxy Crude Oil
Authors: Pal Biswadeep , Naiya Tarun Kumar , Sarkhel Gautam 
Published: October 2022

SummaryWax present in crude oil starts to precipitate during flow through the pipeline below the wax appearance temperature (WAT). The phenomenon creates problems during transportation such as choking in pipeline, pumping pressure, etc. Pour-point depressants (PPDs), wax inhibitors, and other additives are used to remediate wax deposition problems. This paper focuses on the application of a natural extract from Amla fruit (Phyllanthus emblica) in Indian waxy crude oil (WCO) to improve flow behavior and wax deposition rate with varying properties such as temperature, time, and dosage. The result has been compared with commercial additives procured from Deva Drill Tech, India. The extraction procedure was conducted with Amla fruit skin (P. emblica) and with ethanol as a solvent. After the addition of 800-ppm Amla extract, the pour point was reduced by 9°C, and the viscosity was decreased by up to 98% at 50°C. This is due to the interaction and bond formation between synthesized PPD and wax molecules. As a result, less pumping power is required for efficient flow. The thixotropic area was reduced from 164 750 to 134 852 Pa·s after the addition of 800 ppm of synthesized additives. Viscoelastic behavior improved significantly after the addition of Amla extract and commercial additives. This will diminish considerably the energy required to restart the flow of WCO. Morphological changes confirm that more smaller and diffused wax particles were created from large wax agglomerates. The derived PPD is much more effective compared with a commercial one, is more environmentally friendly, and no special attention is required for the pretreatment of PPD-treated crude oil, which ultimately will reduce the project cost.
The liver and muscle secreted Hfe2-protein maintains blood brain barrier integrity
Authors: Wang Xue Fan , Vigouroux Robin , Syonov Michal , Baglaenko Yuriy , Nikolakopoulou Angeliki , Ringuette Dene , Rus Horea , DiStefano Peter , Dufour Suzie , Shabanzahdeh Alireza P. , Lee Seunggi , Mueller Bernhard , Charish Jason , Harada Hidekiyo , Fish Jason , Wither Joan , Wälchli Thomas , Cloutier Jean-Francois , Zlokovic Berislav , Carlen Peter , Monnier Philippe 
Published: October 2022

Abstract
Liver failure causes blood-brain-barrier (BBB) breakdown leading to central nervous system damage, however the mechanisms whereby the liver influences BBB-integrity remain elusive. One possibility is that the liver secretes an as-yet to be identified molecule(s) that circulate in the serum to directly promote BBB integrity. We developed light-sheet imaging for three-dimensional study of BBB function. We show that liver- or muscle-specific knockout of Hfe2 induces BBB breakdown, leading to accumulation of toxic-blood-derived fibrinogen in the brain, lower cortical neuron numbers, and behavioral deficits. In healthy animals, soluble Hfe2 competes with its homologue RGMa for binding to Neogenin, thereby blocking RGMa-induced downregulation of PDGF-B and Claudin-5 in endothelial cells and the ensuing BBB disruption. Hfe2 administration in an animal model of multiple sclerosis prevented paralysis and immune cell infiltration by inhibiting RGMa-mediated BBB alteration. This study has implications for the pathogenesis and potential treatment of diseases associated with BBB dysfunction such as multiple sclerosis.
Hematological toxicity of amphotericin B deoxycholate-based induction therapy in patients with HIV-associated talaromycosis
Authors: Zhou Yihong , LU Tao , Li Yan , Qin Yuanyuan , Lu Yanqiu , Tian Qun , Lan Ke , Zhou Guoqiang , Qin Yingmei , Li Shunmei , Harypursat Vijay , lin shide , Chen Yaokai 
Published: October 2022

Abstract
Background: This study's objective was to investigate the predictors for severe anemia, severe leukopenia, and severe thrombocytopenia when amphotericin B deoxycholate-based induction therapy is used in HIV patients with talaromycosis.
Methods: A total of 170 HIV patients with talaromycosis were enrolled from January 1st, 2019 to September 30th, 2020.
Results: Approximately 42.9%, 20.6%, and 10.6% of the enrolled patients developed severe anemia, severe leukopenia and severe thrombocytopenia, respectively. Baseline lower hemoglobin levels, higher serum creatinine levels, higher AST/ALT ratios, lower sodium levels, and higher administered doses of amphotericin B were observed to be independent risk factors associated with the development of severe anemia. Co-infection with tuberculosis and lower platelet levels at baseline were shown to be independent risk factors associated with the development of severe leukopenia. A lower platelet level at baseline was the independent risk factor found to be associated with the development of severe thrombocytopenia.
Conclusion: The preceding findings reveal risk factors for severe anemia, severe leukopenia, and severe thrombocytopenia, which will favor prevention and timely treatment of hematological toxicity, improvement of patient’s outcomes, shorter hospital stays, and a reduction of the requirement for blood transfusion.
Unintended effects of transgenic rice on grain yield and quality traits determined by quantitative proteomics
Authors: Sun Yue , Chen Huizhen , Chen Zhongkai , Wang Chunlei , Li Bai , Lin Xiaoli , Cai Yicong , Zhou Dahu , Ouyang Linjuan , Zhu Changlan , Xu Jianlong , Peng Xiaosong , He Haohua 
Published: October 2022

AbstractOmics techniques provide effective detection tools for assessing the potential impact of plant composition at the DNA, RNA, and protein levels. Among these, protein is the executor of gene function and the embodiment of biological traits, so that organisms show various genetic characteristics. Proteomics can be used to assess whether genetic engineering will lead to changes in plant traits beyond those introduced by conventional plant breeding. Here, we compare the extent of the proteome occurring in the leaves of three transgenic rice restorer lines expressingCRY1CandCRY2Agenes developed by genetic engineering and their corresponding recurrent parents developed by conventional breeding.CRY1CandCRY2Agenes were inserted into chromosomes 11 and 12, respectively, which significantly improved the resistance of restorer lines toChilo suppressalis. Although differentially expressed proteins could be distinguished between transgenic rice and its recurrent parents, these differences were not sufficient to cause unintended effects on grain yield and quality traits of transgenic rice. In contrast, differences in phenotypic traits are more because of differences in genetic background. Functional cluster analysis showed that the differentially expressed proteins caused by the insertion of exogenous genes mainly involved signal transduction and secondary metabolites(serine, tryptophan) biosynthesis, transport and catabolism pathways. The study successfully used 4D label-free quantitative proteomics technology to assess the unexpected changes in new rice varieties, and the results showed that transgenic rice did not cause unintended effects.
Evaluation of SeptiCyte RAPID, a host immune response assay, for triage of COVID-19 patients requiring hospitalization and potential ICU care
Authors: Montero Maria Milagro , Hardy-Werbin Max , Gallardo Soledad Gonzalez , Torres Erica , Rueda Rebeca , Hannet Irene , Kirk James T , Yager Thomas D , Navalkar Krupa , Arenas Maria del Mar , Arietta-Aldea Itziar , Castañeda Silvia , Gómez-Junyent Joan , Gómez-Zorrilla Silvia , Guerri-Fernández Roberto , Sanchez-Martinez Francisca , López-Montesinos Immaculada , Pelegrín Ivan , Sendra Elena , Sorlí Luisa , Villar-García Judith , Paricio Beatriz Bellosillo , Horcajada Juan Pablo 
Published: October 2022

Abstract
Rationale: Tools for the evaluation of COVID-19 severity would help clinicians with triage decisions, especially the decision whether to admit to ICU. Objective: Evaluation of SeptiCyte RAPID, a host immune response assay (Immunexpress, Seattle USA) as a triaging tool for COVID-19 patients requiring hospitalization and potentially ICU care.
Methods: SeptiCyte RAPID employs a host gene expression signature consisting of the ratio of expression levels of two immune related mRNAs, PLA2G7 and PLAC8, measured from whole blood samples. Blood samples from 146 adult SARS-CoV-2 (+) patients were collected within 48 hours of hospital admission in PAXgene blood RNA tubes at Hospital del Mar, Barcelona, Spain, between July 28th - December 1st, 2020. Data on demographics, vital signs, clinical chemistry parameters, radiology, interventions, and SeptiCyte RAPID were collected and analyzed with bioinformatics methods. The performance of SeptiCyte RAPID for COVID-19 severity assessment and ICU admission was evaluated, relative to the comparator of retrospective clinical assessment by the Hospital del Mar clinical care team.
Measurements and Main Results: SeptiCyte RAPID was able to stratify COVID-19 cases according to clinical severity: critical vs. mild (AUC=0.92, p<0.0001), critical vs. moderate (AUC=0.76, p=0.002), severe vs. mild (AUC=0.85, p=0.0003), severe vs. moderate (AUC=0.63, p=0.05). This discrimination was significantly better (by AUC or p-value) than could be achieved by CRP, lactate, creatine, IL-6, or D-dimer. Some of the critical or severe cases had “early” blood draws (before ICU admission; n=33). For these cases, when compared to moderate and mild cases not in ICU (n=37), SeptiCyte RAPID had AUC=0.78 (p=0.00012).
Conclusions: SeptiCyte RAPID was able to stratify COVID-19 cases according to clinical severity as defined by the WHO COVID-19 Clinical Management Living Guidance of January 25th, 2021. Measurements taken early (before a patient is considered for ICU admission) suggest that high SeptiScores, measured early, could aid in predicting the need for later ICU admission.
Performance Evaluation of Dynamic Load Balancing Algorithms in Cloud Computation
Authors: P RAJAGOPAL T K 
Published: October 2022

Abstract
Cloud environment systems are distributing the workload and workload equally balance the all incoming and outgoing requests between all the processing computer system in cloud network environment is the significant of the biggest tasks cutting-edge nowadays cloud environment. In this point several of the dynamic cloud load balancing procedures and load balancing methodologies has anticipated on behalf of load dispersed and cloud environment systems. Moreover the load advisor strategy for allotting the assigned job capacities among dissimilar data processing centers in a cloud computing is one among the most fundamental factors for improving the cloud computing node performance. In this paper present an investigative and evaluation for the combinations of virtual machine dynamic load balancing algorithms and different load advisor policies. The cloud computing load evaluate these methodologies by simulating on CloudAnalyst simulator and the final consequences reports are accessible based on different cloud computing environment parameters. The outcomes of this load balancing research identify the best load balancing different possible arrangements.
Local climate change perceptions and adaptation strategies across the Central and Eastern Himalayas - a review
Authors: Kuruppath Sanjana Vadakke , Tamma Krishnapriya 
Published: October 2022

Abstract
The Himalayas and the communities that depend on them are highly vulnerable to climate change. Understanding perceptions of climate change among these communities, and the adaptations they undertake to weather climate shocks, can provide vital guidance in designing locally relevant policies. This paper reviews 23 studies that investigated perceptions of climate change in the Central and Eastern Himalayas. From our meta-analysis, we find that respondents across the region report broadly matching perceptions of increasing temperature, decreasing snowfall, and increasingly insufficient and erratic rainfall, along with other environmental changes such as in plant phenology. Studies that compared perceptions to instrument-based data also found a high level of match between the two. Though the perceptions were influenced by several factors such as gender, age and education, they are still valuable as indicators of communities’ most pressing needs. The adaptations people have undertaken are similar across the region and are often short-term and reactive in nature. They include switching to high-yield crop varieties, increased use of chemical fertilisers and pesticides, intensification of irrigation and rainwater harvesting, and livelihood diversification. However, adaptive capacity is dependent on socioeconomic factors, leaving the disadvantaged sections of society more vulnerable to climate change. Local perceptions of climate change are necessary to design inclusive mitigation policies and are a valuable supplement to long-term climate data.
Efficiency of ultrasonic pretreatment on improving biodegradability of tomato wastes: A hypothetical analysis of waste conversion to biohydrogen
Authors: Mahmoodi-Eshkaftaki Mahmood , Houshyar Ehsan , Mahmoudi Mahdi 
Published: October 2022

Abstract

The present study was undertaken to determine the effects of ultrasonic factors (acoustic power and sonication time) and substrate mixture (tomato waste and cow manure) on the degradability of lignocellulosic structures, removal of pollutants and solids of feedstock, and improving bio-H2 production. Integrating multivariate regression modeling and structural equation modeling could achieved this goal. The results showed that the substrates had significant effect on improving the feedstock characteristics at the beginning of fermentation, in which tomato waste required stronger pretreatment. Further, the acoustic power showed more significant effect than sonication time. Analyses showed that the most effective characteristics for bio-H2 fermentation were BOD removal, COD removal and cellulose content removal, in which removal of BOD and COD had the highest effect from the ultrasonic pretreatment factors, and cellulose content removal had the highest effect from tomato waste amount in the mixture. However, to optimize bio-H2 production, substrate mixtures needed ultrasonically pretreatment, in which tomato waste required a stronger pretreatment. The ultrasonic power of 0.1 W/mL at sonication time of 15 min were sufficient to optimize bio-H2, and no need to consume extra energy. In the suitable conditions of pretreatment and substrate mixture, removal of lignin, cellulose and hemicellulose contents increased 57.67%, 24.38% and 38.7% higher than those of a control system, which resulted in an increase of 6% bio-H2 production.
Effect of psychological factors on COVID-19 vaccination side-effects : A survey study among the Korean population
Authors: Kim Eun , Kim Hee Jin , Han Doug Hyun 
Published: October 2022

Abstract
Introduction: Side effects from the COVID-19 vaccine, such as pain, chills, headache, nausea, and fatigue, have caused vaccine hesitancy. Research on the effects of psychological factors on COVID-19 vaccine side effects is insufficient. This study aims to investigate the effects of psychological factors on COVID-19 vaccination side effects.
Materials and Methods: A total of 227 individuals registered for the first dose of the COVID-19 vaccine were recruited for this study. Participants were asked to complete a pre-vaccination questionnaire, including socio-demographic factors, the 5C antecedents of vaccination, and psychological factors (Patient Health Questionnaire: PHQ-9, Generalized Anxiety Disorder-7: GAD-7, Somatic symptom amplification scale: SSAS, and Illness Attitude Scale: IAS). After the first vaccination, participants were asked to complete an online questionnaire regarding vaccine side effects at 20 minutes, three days, and seven days after vaccination. For statistical analysis, an independent t-test, chi-square test, and hierarchical logistic regression analysis were used. In a hierarchical regression analysis, a discrete set of hierarchical variables with vaccine side effects as the dependent variable was added: demographics for Model 1, 5C antecedents of vaccination for Model 2, and psychological factors for Model 3.
Results: Our results indicated that many factors predicted the occurrence of physical side-effects at 20 minutes, three days, and seven days after vaccination. The risk factors for side effects 20 minutes after vaccination were young age, high PHQ, and SSAS scores. Risk factors for side effects three days after vaccination were young age, high constraints, and calculation, and the risk factor seven days after vaccination was a high IAS score.
Conclusion: Our study confirmed that there is a significant relationship between psychological factors and COVID-19 vaccine side-effects occurring 20 minutes, three days, and seven days after vaccination. Depression and somatization were risk factors 20 minutes post-vaccination, constraints and calculation were risk factors three days post-vaccination, and illness anxiety was a risk factor seven days post-vaccination. To reduce vaccine side effects of the general population, screening processes must be considered to provide psychological education to those with these risk factors.
Kisspeptin modulation of nonapeptide and cytochrome P450 aromatase mRNA expression in the brain and ovary of the catfish Heteropneustes fossilis: in vivo and in vitro studies
Authors: Chaube Radha , Sharma Sandhya , Joy Keerikkattil 
Published: October 2022

Abstract

In the catfish Heteropneustes fossilis, Kisspeptins (Kiss) and nonapeptide (NP) hormones (vasotocin, Vt; isotocin, Itb; the Val8 isotocin paralog, Ita) stimulate the brain-pituitary-gonadal (BPG) axis. The present study investigated the functional interactions between these two systems, and that between Kiss and P450 aromatase (P450 arom) in the catfish brain and ovary. Human Kiss1 and catfish Kiss2 produced dosage-dependent effects on vt, itb and ita expression in vivo: 1 ng/g body weight (BW) and 2 ng/g BW inhibited, and 3 ng/g BW stimulated the expressions. The Kiss peptides (5, 10 and 15 nM) for 24 h produced a concentration - dependent stimulation of the gene expression in vitro. Kiss2 was more effective than Kiss1, both in vivo and in vitro. The Kiss1 administration stimulated ovarian vt, itb and ita expression at 2 and 3 ng/g BW and the Kiss2 treatment inhibited the expression at 1 ng/g BW and stimulated it at 2 and 3 ng/g BW. The Kiss receptor antagonist peptide 234 inhibited the NP mRNA expressions in a dosage/concentration-dependent manner. The Kiss peptide administration stimulated brain-specific cyp19a1b and ovary-specific cyp19a1a P450 arom expression dosage-dependently, both in vivo and in vitro. Peptide 234 inhibited the enzyme gene expression significantly, both in vivo and in vitro. The results show that Kiss peptides modulate functional targets like NP and E2 in the brain and ovary to influence reproductive functions.