bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long COVID and symptom trajectory in a representative sample of Americans in the first year of the pandemic
Authors: Wu Qiao , Ailshire Jennifer A. , Crimmins Eileen M. 
Published: July 2022

AbstractPeople who have COVID-19 can experience symptoms for months. Studies on long COVID in the population lack representative samples and longitudinal data focusing on new-onset symptoms occurring with COVID while accounting for pre-infection symptoms. We use a sample representing the U.S. community population from the Understanding America Study COVID-19 Survey, which surveyed around 8000 respondents bi-weekly from March 2020 to March 2021. Our final sample includes 308 infected individuals who were interviewed one month before, around the time of, and 12 weeks after infection. About 23% of the sample experienced new-onset symptoms during infection which lasted for more than 12 weeks, and thus can be considered as having long COVID. The most common new-onset persistent symptoms among those included in the study were headache (22%), runny or stuffy nose (19%), abdominal discomfort (18%), fatigue (17%), and diarrhea (13%). Long COVID was more likely among obese individuals (OR = 5.44, 95% CI 2.12–13.96) and those who experienced hair loss (OR = 6.94, 95% CI 1.03–46.92), headache (OR = 3.37, 95% CI 1.18–9.60), and sore throat (OR = 3.56, 95% CI 1.21–10.46) during infection. There was a lack of evidence relating risk to age, gender, race/ethnicity, education, current smoking status, or comorbid chronic conditions. This work provides national estimates of long COVID in a representative sample after accounting for pre-infection symptoms.
A numerical approach to determine the optimal condition of the gas anti-solvent supercritical process for nanoparticles production
Authors: Saadati Ardestani Nedasadat , Amani Mitra 
Published: July 2022

AbstractSupercritical gas antisolvent (GAS) process is an efficient method for nanoparticles production, in which accurate selection of operational condition is essential. Thermodynamic models can be applied for evaluation the phase equilibrium behavior and determination the required precipitation pressure of GAS process. In this research, thermodynamic behavior of (CO2—dimethyl sulfoxide (DMSO)) binary system and both of (CO2–DMSO-anthraquinone Violet 3RN (AV3RN)) and (CO2–DMSO-solvent Yellow 33 (SY33)) ternary systems in the GAS process were studied at different temperatures (308, 318, 328 and 338) K and pressures (1.0–14.0) MPa, using Peng–Robinson equation of state (PR-EoS). The minimum precipitation pressure of AV3RN and SY33 at 308, 318, 328 and 338 K were 7.80, 8.57, 9.78 and 11 MPa and 8, 8.63, 9.5 and 10.77 MPa, respectively. Also, the mole fraction of substances in liquid phase of ternary systems were determined by PR-EoS, at 328 K versus pressure. The accuracy of the obtained results were investigated using the experimental data reported in the literatures.
Functional characterization of dopamine and norepinephrine transport across the apical and basal plasma membranes of the human placental syncytiotrophoblast
Authors: Horackova Hana , Karahoda Rona , Vachalova Veronika , Turkova Helena , Abad Cilia , Staud Frantisek 
Published: July 2022

AbstractThe human placenta represents a unique non-neuronal site of monoamine transporter expression, with pathophysiological relevance during the prenatal period. Monoamines (serotonin, dopamine, norepinephrine) are crucial neuromodulators for proper placenta functions and fetal development, including cell proliferation, differentiation, and neuronal migration. Accumulating evidence suggests that even a transient disruption of monoamine balance during gestation may lead to permanent changes in the fetal brain structures and functions, projecting into adulthood. Nonetheless, little is known about the transfer of dopamine and norepinephrine across the placental syncytiotrophoblast. Employing the method of isolated membranes from the human term placenta, here we delineate the transport mechanisms involved in dopamine and norepinephrine passage across the apical microvillous (MVM) and basal membranes. We show that the placental uptake of dopamine and norepinephrine across the mother-facing MVM is mediated via the high-affinity and low-capacity serotonin (SERT/SLC6A4) and norepinephrine (NET/SLC6A2) transporters. In the fetus-facing basal membrane, however, the placental uptake of both monoamines is controlled by the organic cation transporter 3 (OCT3/SLC22A3). Our findings thus provide insights into physiological aspects of dopamine and norepinephrine transport across both the maternal and fetal sides of the placenta. As monoamine transporters represent targets for several neuroactive drugs such as antidepressants, our findings are pharmacologically relevant to ensure the safety of drug use during pregnancy.
Early and late onset sepsis and retinopathy of prematurity in a cohort of preterm infants
Authors: Bonafiglia Elena , Gusson Elena , Longo Rosa , Ficial Benjamim , Tisato Maria Giulia , Rossignoli Sara , Caltran Giulia , Pedrotti Emilio , Beghini Renzo , Marchini Giorgio 
Published: July 2022

AbstractThis study investigates the impact of antenatal and postnatal infection or inflammation on the onset and progression of Retinopathy of Prematurity (ROP). We retrospectively collected clinical and demographic data of preterm infants with birth weight ≤ 1500 g or gestational age < 30 weeks admitted to the neonatal intensive care unit of Verona from 2015 to 2019. Uni- and multivariable analysis was performed to evaluate the potential effect of selected variables on the occurrence of any stage ROP and its progression to severe ROP, defined as ROP requiring treatment. Two hundred and eighty neonates were enrolled and 60 of them developed ROP (21.4%). Oxygen need for 28 days and late-onset sepsis (LOS) increased the risk of any grade ROP after adjusting for birth weight and gestational age (OR 6.35, 95% CI 2.14–18.85 and OR 2.49, 95% CI 1.04–5.94, respectively). Days of mechanical ventilation and of non-invasive ventilation increased the risk of progression to severe ROP after adjusting for birth weight and gestational age (OR 1.08, CI 1.02–1.14 and OR 1.06, CI 1.01–1.11, respectively). Exposure to infection with production of inflammatory mediators may contribute to increase the risk of ROP occurrence in very preterm neonates.
Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential
Authors: Korczak Maciej , Roszkowski Piotr , Granica Sebastian , Piwowarski Jakub P. 
Published: July 2022

AbstractUrolithin A (UA, 1), a gut microbiota postbiotic metabolite is attributed to express interesting biological activities indicated by in vitro, in vivo and clinical studies. Due to its strong anti-inflammatory properties it is considered as a promising lead molecule for further drug development, however, its strong phase II metabolism, severely limits its oral application. Therefore, monoesterified UA derivatives with selected NSAIDs: ibuprofen (Mix 3a/3b), mefenamic acid (Mix 4a/4b), diclofenac (Mix 5a/5b) and aspirin (Mix 6a/6b) were designed. Performed array of stability assays indicated Mix 4a/4b as a most suitable candidate for further studies due to its exceptional stability in human plasma. Thus, we evaluated effects of Mix 4a/4b on cell viability as well as the impact on cytokines secretion in THP-1 derived macrophages and compared it to UA. At high concentration (50 µM) Mix 4a/4b expressed a cytotoxic effect, however at concentration of 5 µM it significantly suppressed TNF-α secretion, and significantly increased ani-inflammatory IL-10 secretion at 10 µM without affecting cell viability. This work has led to selection of a novel UA derivatives, which are stable in solutions and in human plasma as well as posess anti-inflammatory activity towards THP-1 macrophages at non-cytotoxic concentrations.
Latent class trajectories of biochemical parameters and their relationship with risk of mortality in ICU among acute organophosphorus poisoning patients
Authors: Farooqui Waqas Ahmed , Uddin Mudassir , Qadeer Rashid , Shafique Kashif 
Published: July 2022

AbstractAcute poisoning is a global public health challenge. Several factors played role in high mortality among acute organophosphorus poisoning (OP) poisoning patients including clinical, vitals, and biochemical properties. The traditional analysis techniques use baseline measurements whereas latent profile analysis is a person-centered approach using repeated measurements. To determine varying biochemical parameters and their relationship with intensive care unit (ICU) mortality among acute organophosphorus poisoning patients through a latent class trajectory analysis. The study design was a retrospective cohort and we enrolled data of 299 patients admitted between Aug’10 to Sep’16 to ICU of Dr. Ruth K. M. Pfau, Civil Hospital, Karachi. The dependent variable was ICU-mortality among OP poisoning patients accounting for ICU stay, elapsed time since poison ingestion, age, gender, and biochemical parameters (including electrolytes (potassium, chloride, sodium), creatinine, urea, and random blood sugar). Longitudinal latent profile analysis is used to form the trajectories of parameters. In determining and comparing the risk of ICU-mortality we used Cox-Proportional-Hazards models, repeated measures and trajectories were used as independent variables. The patients’ mean age was 25.4 ± 9.7 years and ICU-mortality was (13.7%, n = 41). In trajectory analysis, patients with trajectories (normal-increasing and high-declining creatinine, high-remitting sodium, normal-increasing, and high-remitting urea) observed the highest ICU-mortality i.e. 75% (6/8), 67% (2/3), 80% (4/5), 75% (6/8), and 67% (2/3) respectively compared with other trajectories. On multivariable analysis, compared with patients who had normal consistent creatinine levels, patients in normal-increasing creatinine class were 15 times [HR:15.2, 95% CI 4.2–54.6], and the high-declining class was 16-times [HR 15.7, 95% CI 3.4–71.6], more likely to die. Patients in with high-remitting sodium, the trajectory was six-times [HR 5.6, 95% CI 2.0–15.8], normal-increasing urea trajectory was four times [HR 3.9, 95% CI 1.4–11.5], and in extremely high-remitting urea trajectory was 15-times [HR 15.4, 95% CI 3.4–69.7], more likely to die compared with those who were in normal-consistent trajectories of sodium and urea respectively. Among OP poisoning patients an increased risk of ICU-mortality were significantly associated with biochemical parameters (sodium, urea, creatinine levels) using latent profile technique.
Engineering nonlinear optical phenomena by arbitrarily manipulating the phase relationships among the relevant optical fields
Authors: Liu Weiyong , Ohae Chiaki , Zheng Jian , Tahara Soma , Suzuki Masaru , Minoshima Kaoru , Ogawa Hisashi , Takano Tetsushi , Katsuragawa Masayuki 
Published: July 2022

AbstractNonlinear optical processes are intrinsically dominated by the phase relationships among the relevant electromagnetic fields, including the phase of nonlinear polarization produced in them. If one can arbitrarily manipulate these phase relationships at a variety of desired interaction lengths, direct and highly designable manipulations for the nonlinear optical phenomenon could be achieved. Here, we report a proof-of-principle experiment in which a high-order Raman-resonant four-wave-mixing process is used as a representative nonlinear optical process and is tailored to a variety of targets by implementing such arbitrary manipulations of the phase relationships in the nonlinear optical process. We show that the output energy is accumulated to a specific, intentionally selected Raman mode on demand; and at the opposite extreme, we can also distribute the output energy equally over broad high-order Raman modes in the form of a frequency comb. This concept in nonlinear optical processes enables an attractive optical technology: a single-frequency tunable laser broadly covering the vacuum ultraviolet region, which will pave the way to frontiers in atomic-molecular-optical physics in the vacuum ultraviolet region.
A corticostriatal pathway mediating self-efficacy enhancement
Authors: Shany Ofir , Gurevitch Guy , Gilam Gadi , Dunsky Netta , Reznik Balter Shira , Greental Ayam , Nutkevitch Noa , Eldar Eran , Hendler Talma 
Published: July 2022

AbstractForming positive beliefs about one’s ability to perform challenging tasks, often termed self-efficacy, is fundamental to motivation and emotional well-being. Self-efficacy crucially depends on positive social feedback, yet people differ in the degree to which they integrate such feedback into self-beliefs (i.e., positive bias). While diminished positive bias of this sort is linked to mood and anxiety, the neural processes by which positive feedback on public performance enhances self-efficacy remain unclear. To address this, we conducted a behavioral and fMRI study wherein participants delivered a public speech and received fictitious positive and neutral feedback on their performance in the MRI scanner. Before and after receiving feedback, participants evaluated their actual and expected performance. We found that reduced positive bias in updating self-efficacy based on positive social feedback associated with a psychopathological dimension reflecting symptoms of anxiety, depression, and low self-esteem. Analysis of brain encoding of social feedback showed that a positive self-efficacy update bias associated with a stronger reward-related response in the ventral striatum (VS) and stronger coupling of the VS with a temporoparietal region involved in self-processing. Together, our findings demarcate a corticostriatal circuit that promotes positive bias in self-efficacy updating based on social feedback, and highlight the centrality of such bias to emotional well-being.
Compensatory Articulation Errors in Patients With Velopharyngeal Dysfunction and Palatal Anomalies
Authors: Nachmani Ariela , Biadsee Ameen , Masalha Muhamed , Kassem Firas 
Published: July 2022

Purpose:The aim of this study was to assess the frequency and types of compensatory articulations (CAs) in nonsyndromic patients with velopharyngeal dysfunction (VPD) and various palatal anomalies and to determine the relationship between the frequency of CAs, type of palatal anomaly, and phonological errors.Method:A total of 783 nonsyndromic, Hebrew-speaking patients with VPD and various palatal anomalies (cleft lip and palate [CLP], cleft palate [CP], submucous CP [SMCP], occult submucous CP [OSMCP], or non-CP) were studied retrospectively. Perceptual VPD tests, including articulation and phonological assessment, were conducted. CAs were described as below the level of the defect in the vocal tract (abnormal backing of oral targets to post-uvular place) or in front of it within the oral cavity (palatalization) and at the velopharyngeal port.Results:Among 783 patients, 213 (27.2%) had CAs. Most CAs (18.4%) occurred below the level of the defect, followed by CAs at the velopharyngeal port (12.0%) or in front of it (4.9%). No differences were found in the frequency of CAs between patients with CP (47.8%) or CLP (52.6%) and between those with non-CP (13.6%) or OSMCP (14.7%). SMCP patients had lower frequency of CAs (29.8%) than CP (p = .003) and CLP (p =  .002) patients but higher frequency than OSMCP (p = .002) and non-CP (p =  .002) patients did. Among the 783 patients, 247 (31.5%) had phonological errors. A higher frequency of phonological errors was found in patients with CAs (55.4%) compared to those without (22.6%) and in all palatal anomaly groups except CLP (31.4% vs. 23.9%).Conclusions:CAs in nonsyndromic patients with VPD remained relatively high in all age groups, up to adulthood. CAs are influenced by inadequate velar length following palatal repair, as well as by oral structural abnormalities, whereas poor muscle function due to OSMCP and/or abnormal size and/or shape of nasopharynx has less influence. Errors produced in front of the velopharyngeal port are influenced by the structural anomaly of CLP. This information may contribute to general phonetic and phonological theories and genetic investigations about CP anomalies.
A single‐source nine‐level inverter with quadratic boost ability for renewable energy applications
Authors: Tayyab Mohammad , Sarwar Adil , Bakhsh Farhad Ilahi , Al‐Durra Ahmed , Siddiqui Khadim Moin 
Published: July 2022

AbstractA nine‐level inverter with quadratic boost ability is proposed in this paper. The presented topology produces quadruple boosted output voltage by utilizing 10 switches, one diode, two capacitors, and a single dc source. In the proposed topology a back‐end H‐bridge is not required to produce negative voltage levels, which in turn reduces the voltage stress across the switches to the maximum of twice the input voltage. The two switched capacitors (SC) are charged to the dc source voltage rating and twice the voltage rating of the dc source, respectively, to produce quadruple voltage boosting. The high‐voltage boosting capability makes it suitable for the integration of renewable energy sources to the grid. Nearest level control (NLC)‐based modulation technique is applied to produce gate driver signals for the inverter circuit. The proposed topology is compared with the recently published topologies in terms of used components such as switches, diodes, sources, and capacitors are made so as to show the advantages of the presented reduced component count topology. Finally, simulation and hardware results are obtained under certain loading conditions to validate the operability of the proposed topology. The total harmonic distortion (THD) of the proposed topology at the unity modulation index is 8.2%.
Iodine-Catalyzed Synthesis of Alkylthio-Substituted 1,4-Enediones from Styrenes and Dialkyl Sulfoxides
Authors: Deb Mohit L. , Baruah Pranjal K. , Rastogi Gaurav K. 
Published: July 2022

AbstractWe have developed an efficient iodine-catalyzed route for the synthesis of 2-(alkylthio)-substituted 1,4-enedione derivatives from styrenes under an open air atmosphere. Styrenes are heated with a range of sulfoxides in the presence of iodine and potassium persulfate to afford the desired products in high yields. Except for DMSO, all the sulfoxides are synthesized in the laboratory and are used crude. The products are formed as mixtures of E and Z stereoisomers that are easily separable by column chromatography. Both oxygen atoms of 1,4-enedione product originate from aerial oxygen. A mechanism is proposed based on control experiments and literature reports.
Family Language Policies of Vietnamese–Australian Families
Authors: Tran Van H. , Verdon Sarah , McLeod Sharynne , Wang Cen 
Published: July 2022

AbstractThis study aimed to investigate reported family language policies (quy tắc sử dụng ngôn ngữ cho gia đình) and language maintenance practices among Vietnamese–Australian parents. This mixed-methods study collected 151 Vietnamese–Australian parents' responses to close- and open-ended questions within an online questionnaire that was available both in English and Vietnamese. Bivariate analyses and logistic regression were conducted to explore associations between family language policies and factors related to demographics and Spolsky's language policy theory. Content analysis was undertaken in NVivo to investigate family language policies. One-third of the participants (35.6%) reported to have a family language policy and 72.5% of those with a policy indicated that they consistently implemented their policy. Significant factors associated with having a family language policy were parents' higher Vietnamese proficiency, more Vietnamese language use with their children, and intention of future residence in Vietnam. The four identified language policies were as follows: (1) using Vietnamese with the nuclear family (FLP1), (2) Vietnamese outside the nuclear family (FLP2), (3) English at home (FLP3), and (4) English outside the home (FLP4). Some families used more than one of these concurrently. This is one of the first large-scale mixed-method studies to explore family language policies, and the first to explore this issue with Vietnamese-speaking families in Australia. Many Vietnamese–Australian families do not explicitly have a family language policy aimed at maintaining Vietnamese at home; therefore, the Vietnamese–Australian community is at risk of a shift toward English language dominance and home language loss. As a result, the benefits of multilingualism within the Vietnamese–Australian community may be lost without support from the government and community to maintain their home language.
Often Encountered but Rarely Reported: Challenges in Selecting Language(s) for Intervention in Bi/Multilingual Children with Autism Spectrum Disorder
Authors: Srikar Malavi , Raju Reny , Dadlani Nikita , Swaminathan Divya , Vaidhyanathan Prathiksha , Meera Shoba S. 
Published: July 2022

AbstractIndia is a socioculturally and linguistically diverse country. Most often individuals grow up exposed to more than one language. Apart from exposure to native and community languages, there is a growing preference for English as the language of formal education and employment. Previous studies demonstrated that bilingual children with autism spectrum disorder (ASD) develop language similar to their monolingual nonverbal IQ-matched ASD peers. However, most of these studies have been conducted in countries in which English is the primary language for majority of the population. Although existing studies support a bilingual environment for children with ASD, professionals still seem to advise families' use of a monolingual approach. This paper reviews and discusses factors that influence the selection of language(s) for intervention in young children with ASD in bi/multilingual environments. These are discussed under three areas namely, (1) language environment of the child, (2) parent/caregivers' perspectives regarding bi/multilingual exposure, and (3) medium of education and availability of intervention services. This paper also highlights the complexities involved in the language selection process for intervention using four case vignettes. Based on the review and findings from the case vignettes, it is evident that there is a need for (1) sensitizing fellow professionals regarding the increasing shift toward a bi/multilingual approach, (2) formulating guidelines for this decision-making process, and (3) continuing to develop an evidence base for adopting multilingual approach for intervention in a socioculturally and linguistically diverse country like India.
Tratamento de pacientes com diagnóstico de tumor ósseo de células gigantes: Experiência de um hospital filantrópico no Piauí, Brasil
Authors: Aguiar Leonardo Telles Alves de , Vasconcelos Juliani Barros Moura de , Ribeiro Marcelo Barbosa 
Published: July 2022

Resumo
Objetivo Avaliar o tratamento fornecido a pacientes com diagnóstico de tumor de células gigantes ósseo atendidos no período de 2009 a 2019 em um hospital filantrópico, bem como determinar o perfil clínico e epidemiológico regional, visando enriquecer os dados nacionais e comparar os achados com a literatura existente.
Métodos Estudo analítico, observacional e transversal, com coleta retrospectiva e abordagem quantitativa, com análise de prontuários de pacientes diagnosticados com tumor de células gigantes atendidos em um hospital filantrópico no período de 2009 a 2019.
Resultados Foram avaliados 49 prontuários, sendo que 55,1% eram de mulheres, com 53,1% dos casos na faixa etária de 20 a 40 anos, 69,4% de casos de grau III de Campanacci, e 30,6% acometendo a extremidade proximal da tíbia. Observou-se baixo índice de fratura patológica secundária ao tumor e de metástase pulmonar. A cirurgia intralesional foi realizada em 69,5% dos pacientes. Houve recidiva em 16,3% dos casos.
Conclusão Os critérios usados para diagnóstico, classificação e tratamento em nosso serviço seguiram os padrões estabelecidos pela literatura, e podem orientar novas pesquisas e melhorar o prognóstico local futuramente.