bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-Term Weather Forecast Skill of Artificial Neural Networks
Authors: Hennon Christopher C. , Coleman Andrew , Hill Andrew 
Published: August 2022

Abstract
We evaluate the short-term weather forecast performance of three flavors of artificial neural networks (NNs): feed forward back propagation, radial basis function, and generalized regression. To prepare the application of the NNs to an operational setting, we tune NN hyperparameters using over two years of historical data. Five objective guidance products serve as predictors to the NNs: North American Mesoscale and Global Forecast System model output statistics (MOS) forecasts, the High-Resolution Rapid Refresh (HRRR) model, National Weather Service forecasts, and the National Blend of Models product. We independently test NN performance using 96 real-time forecasts of temperature, wind, and precipitation across 11 U.S. cities made during the WxChallenge, a weather forecasting competition. We demonstrate that all NNs significantly improve short-range weather forecasts relative to the traditional objective guidance aids used to train the networks. For example, 1-day maximum and minimum temperature forecast error is 20%–30% lower than MOS. However, NN improvement over multiple linear regression for short-term forecasts is not significant. We suggest this may be attributed to the small number of training samples, the operational nature of the experiment, and the short forecast lead times. Regardless, our results are consistent with previous work suggesting that applying NNs to model forecasts can have a positive impact on operational forecast skill and will become valuable tools when integrated into the forecast enterprise.

Significance Statement
We used approximately two years of historical weather data and objective forecasts for a number of cities to tune a series of artificial neural networks (NNs) to forecast 1-day values of maximum and minimum temperature, maximum sustained wind speed, and quantitative precipitation. We compare forecast error against common objective guidance and multiple linear regression. We found that the NNs exhibit about 25% lower error than common objective guidance for temperature forecasting and 50% lower error for wind speed. Our results suggest that NNs will be a valuable contributor to improving weather forecast skill when adopted into the existing forecast enterprise.
Housing and loneliness among individuals with serious mental illnesses
Authors: Nagata Shinichi , Brusilovskiy Eugene , Townley Greg , McCormick Bryan , Thomas Elizabeth C. , Snethen Gretchen , Salzer Mark S. 
Published: August 2022

Background: People with serious mental illnesses (SMI) have higher levels of loneliness than the general population. Furthermore, people with SMI tend to be less satisfied with their housing and tend to move more frequently. Aim: This study aims to examine relationships between housing variables (whom they live with, duration of residence, and satisfaction) and loneliness among individuals with SMI. Methods: Data were collected from 188 adults with SMI in greater Philadelphia area. Classification and Regression Trees (CART) were used to examine whether whom they live with, duration of residence, and housing satisfaction were associated with loneliness. Results: Housing satisfaction was found to be the most prominent predictor of loneliness. Those who were unsatisfied with their overall housing conditions always had the highest level of loneliness, regardless of other factors. Even if they were satisfied with their housing conditions, their loneliness was higher if they had just moved to the new residence. Participants had lower loneliness the longer they lived in a residence and had the lowest loneliness levels after about three years. Conclusion: Housing is associated with loneliness among people with SMI. Psychiatric service providers should increase support to factors contributing to housing satisfaction and duration of residence, including active engagement in the community.
Nutritional knowledge and immunity-boosting food consumption patterns before and after the COVID-19 pandemic lockdown periods in Osun State, Nigeria
Authors: Folorunso Adekunle , Olu-Lawal Fareedah , Omoniyi Saheed 
Published: August 2022

Background: A healthy diet can ensure a robust immune system that can resist any onslaught by viruses and bacteria. Aim: To assess the nutritional knowledge and consumption patterns of immunity boosting foods of adults before & after the COVID-19 pandemic lockdown periods and the effect of the lockdown on daily food intake among respondents in selected towns in Osun state. Methods: Cross sectional data was collected from six largest local governments areas purposively selected from the three senatorial districts of Osun State (n = 1000) using a well-structured, self-administered questionnaire and the data collected was analyzed using mean, standard deviation, and Pearson's correlation test The study assessed the food intakes of adults using a qualitative food frequency questionnaire. Results: The results indicated that the majority (89.8%) of the respondents had high knowledge of the occurrence of the COVID-19 pandemic. Daily food intake was affected by COVID-19 lockdown, consumption of healthy food among the respondents was high during lockdown as 77% strongly agreed that vitamins and minerals supplement can be considered healthy and immunity boosting, while there was a reduction in the consumption of healthy foods after the lockdown periods. The test of hypothesis showed that the occurrence of pandemic and nutritional knowledge had a significant relationship with the consumption of healthy foods. Conclusion: This study extends and confirms previous research on high nutritional knowledge of immunity-boosting foods in relation to COVID-19 among the respondents and a general reduction in the consumption of healthy foods after the COVID −19 lockdown periods.
RNA-seq analysis reveals differentially expressed inflammatory chemokines in a rat retinal degeneration model induced by sodium iodate
Authors: Chen Sheng , Liu Guo , Liu Xin , Wang Yun , He Fen , Nie Danyao , Liu Xinhua , Liu Xuyang 
Published: August 2022

Objective Retinal degeneration (RD) is a group of serious blinding eye diseases characterized by photoreceptor cell apoptosis and progressive degeneration of retinal neurons. However, the underlying mechanism of its pathogenesis remains unclear. Methods In this study, retinal tissues from sodium iodate (NaIO3)-induced RD and control rats were collected for transcriptome analysis using RNA-sequencing (RNA-seq). Analysis of white blood cell-related parameters was conducted in patients with retinitis pigmentosa (RP) and age-related cataract (ARC) patients. Results In total, 334 mRNAs, 77 long non-coding RNAs (lncRNAs), and 20 other RNA types were identified as differentially expressed in the retinas of NaIO3-induced RD rats. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that differentially expressed mRNAs were mainly enriched in signaling pathways related to immune inflammation. Moreover, we found that the neutrophil-to-lymphocyte ratio was significantly higher in RP patients than in ARC patients. Conclusion Overall, this study suggests that multiple chemokines participating in systemic inflammation may contribute to RD pathogenesis.
Hip Impingement Location in Maximal Hip Flexion in Patients With Femoroacetabular Impingement With and Without Femoral Retroversion
Authors: Lerch Till D. , Antioco Tiziano , Boschung Adam , Meier Malin K. , Schmaranzer Florian , Novais Eduardo N. , Tannast Moritz , Steppacher Simon D. 
Published: August 2022

Background: Symptomatic patients with femoroacetabular impingement (FAI) have limitations in daily activities and sports and report the exacerbation of hip pain in deep flexion. Yet, the exact impingement location in deep flexion and the effect of femoral version (FV) are unclear. Purpose: To investigate the acetabular and femoral locations of intra- or extra-articular hip impingement in flexion in patients with FAI with and without femoral retroversion. Study Design: Cross-sectional study; Level of evidence, 3. Methods: An institutional review board–approved retrospective study involving 84 hips (68 participants) was performed. Of these, symptomatic patients (37 hips) with anterior FAI and femoral retroversion (FV <5°) were compared with symptomatic patients (21 hips) with anterior FAI (normal FV) and with a control group (26 asymptomatic hips without FAI and normal FV). All patients were symptomatic, had anterior hip pain, and had positive anterior impingement test findings. Most of the patients had hip/groin pain in maximal flexion or deep flexion or during sports. All 84 hips underwent pelvic computed tomography (CT) to measure FV as well as validated dynamic impingement simulation with patient-specific CT-based 3-dimensional models using the equidistant method. Results: In maximal hip flexion, femoral impingement was located anterior-inferior at 4 o’clock (57%) and 5 o’clock (32%) in patients with femoral retroversion and mostly at 5 o’clock in patients without femoral retroversion (69%) and in asymptomatic controls (76%). Acetabular intra-articular impingement was located anterior-superior (2 o’clock) in all 3 groups. In 125° of flexion, patients with femoral retroversion had a significantly ( P < .001) higher prevalence of anterior extra-articular subspine impingement (54%) and anterior intra-articular impingement (89%) compared with the control group (29% and 62%, respectively). Conclusion: Knowing the exact location of hip impingement in deep flexion has implications for surgical treatment, sports, and physical therapy and confirms previous recommendations: Deep flexion (eg, during squats/lunges) should be avoided in patients with FAI and even more in patients with femoral retroversion. Patients with femoral retroversion may benefit and have less pain when avoiding deep flexion. For these patients, the femoral location of the impingement conflict in flexion was different (anterior-inferior) and distal to the cam deformity compared with the location during the anterior impingement test (anterior-superior). This could be important for preoperative planning and bone resection (cam resection or acetabular rim trimming) during hip arthroscopy or open hip preservation surgery to ensure that the region of impingement is appropriately identified before treatment.
Clinical and Radiographic Outcomes of Percutaneous Third-Generation Double First Metatarsal Osteotomy Combined With Closing-Wedge Proximal Phalangeal Osteotomy for Moderate and Severe Hallux Valgus
Authors: Castellini Jorge Luis Alberto , Grande Ratti María Florencia , Gonzalez Diego Leandro 
Published: August 2022

Background: The treatment for severe hallux valgus deformity presents a challenge with high risk of complications. Third generation MIS techniques have increased their publications in recent years. The aim was to compare clinical and radiologic outcomes in moderate and severe cases and report minor and major complications. Methods: Retrospective series of cases with prospective data collection of 156 consecutive feet that underwent percutaneous double first metatarsal osteotomy (PEDO) and first phalanx osteotomy between 2008 and 2019 for moderate (hallux valgus angle [HVA] between ≥20 and <40 degrees and/or intermetatarsal angle [IMA] <16 degrees) and severe (HVA ≥40 degrees and/or IMA ≥16 degrees) hallux valgus deformities. Primary outcomes included radiographic and clinical parameters. Secondary outcomes included minor and major complications. Results: A total of 156 procedures were performed in 128 patients. Mean age was 54.3 years (SD 14.3) (range, 19-82 years), median follow-up was 22.6 months (range, 12-96 months). Radiographic changes pre- to postoperation were as follows: HVA changed from 38.2 (SD 10.1) degrees to 11.2 (SD 8.3) degrees ( P < .001), IMA from 14.7 (SD 3.2) degrees to 7.9 (SD 3.7) degrees ( P < .001), and distal articular metatarsal angle from 19.7 (SD 6.3) degrees to 8.8 (SD 5.7) degrees ( P < .001) after PEDO technique. Clinical changes pre- to postoperation were as follows: American Orthopaedic Foot & Ankle Society ankle-hindfoot scale scores improved from 47.3 (SD 16.5) to 87 (SD 11.6) ( P < .001) and visual analog scale scores from 5 (2.7) to 0.9 (1.3) ( P < .001). The satisfaction rate was 97% in the total sample. Recurrence rate (HVA ≥20 degrees) was 7.7%. Hallux varus (HVA <0 degrees) occurred in 5.8%, acute osteomyelitis in 1.3%, partial avascular necrosis in 0.6%, screw removal in 0.6%, and reoperation in 1.9%. No nonunion was observed. Conclusion: Clinical and radiographic parameters improved significantly, with a minimum of 12 months of follow-up in moderate and severe hallux valgus. Long experience in percutaneous surgery and specific instruments are needed for this technique. Recurrence was linked to preoperative HVA ≥40 degrees and postoperative tibial sesamoid position; Hallux varus was linked to lateral soft tissue release. Level of Evidence: Level IV, case series.
Business for peace: How entrepreneuring contributes to Sustainable Development Goal 16
Authors: Gallo Peter Jack , Sosa Santiago , Velez-Calle Andres 
Published: August 2022

We examine entrepreneurial ventures in a post-conflict context to identify practices that are helpful for companies operating in conflict zones while contributing to the United Nations’ Sustainable Development Goal 16 (SDG 16)—Peace, Justice, and Strong Institutions. Using emancipatory entrepreneuring as our theoretical lens, we analyze entrepreneurial ventures where ex-combatants seek to create economic opportunities and challenge the status quo of violence, poverty, and inequality in their rural communities. We develop four qualitative case studies of ex-combatant entrepreneurship to identify the activities that enable them to grow their businesses while promoting peace. We identify actor distance and entrepreneurial stage as key dimensions for defining a matrix of relationship arrangements that facilitate venture success and peacebuilding efforts. We conclude with a summary of our contributions and implications for research and practice. JEL Classifications: D63, D74, H56, L14, L26
The construction of the responsible patient in complex palliative care: interpreting palliative care policies
Authors: Thoresen Lisbeth , Røberg Anne-Stine Bergquist 
Published: August 2022

Background: To contribute with knowledge to health policy development, this article presents a critical discourse analysis of two Norwegian official reports on palliative care published in 1999 and 2017. Methods: We identify, describe and discuss how linguistic features in policy documents contribute to and engender a distinct change from 1999 to 2017 in how patients are framed, documenting the development of palliative care. Results: The analysis identifies and considers two interwoven discourses: the discourse of accountability and the discourse of complexity. The patient moves from being described as in need of care, in the 1999 report, to being described as an active and responsible patient making proper choices, in the 2017 report. Conclusion: Result of this policy development might be less involvement of professionals and focus on existential questions, and more responsibility on patients for their prospective wellbeing and health: a change that we argue should be considered and counteracted in upcoming policy processes considering palliative care.
Impact of fremanezumab on disability outcomes in patients with episodic and chronic migraine: a pooled analysis of phase 3 studies
Authors: McAllister Peter , Cohen Joshua M. , Campos Verena Ramirez , Ning Xiaoping , Janka Lindsay , Barash Steve 
Published: August 2022

Abstract
Background
Migraine is the second leading cause of disability worldwide. Although many preventive treatments reduce migraine frequency and severity, it is unclear whether these treatments reduce migraine-related disability in a clinically meaningful way. This pooled analysis evaluated the ability of fremanezumab to reduce migraine-related disability, based on responses and shifts in severity in patient-reported disability outcomes.

Methods
This pooled analysis included 3 double-blind phase 3 trials (HALO EM, HALO CM, FOCUS) in which patients with episodic or chronic migraine were randomly assigned 1:1:1 to quarterly or monthly fremanezumab or matched placebo for 12 weeks. Migraine-related disability was assessed using the 6-item Headache Impact Test (HIT-6) and Migraine Disability Assessment (MIDAS) questionnaires. A clinically meaningful improvement in disability was defined per American Headache Society guidelines: for HIT-6, a ≥ 5-point reduction; for MIDAS, a ≥ 5-point reduction when baseline score was 11 to 20 or ≥ 30% reduction when baseline score was > 20. Proportions of patients who demonstrated shifts in severity for each outcome were also evaluated.

Results
For patients with baseline MIDAS scores of 11 to 20 (n = 234), significantly higher proportions achieved 5-point reductions from baseline in MIDAS scores with fremanezumab (quarterly, 71%; monthly, 70%) compared with placebo (49%; both P ≤ 0.01). For patients with baseline MIDAS scores of > 20 (n = 1266), proportions achieving ≥30% reduction from baseline in MIDAS scores were also significantly higher with fremanezumab (quarterly, 69%; monthly, 79%) compared with placebo (58%; both P < 0.001). For HIT-6 scores, proportions of patients achieving 5-point reductions from baseline were significantly higher with fremanezumab (quarterly, 53%; monthly, 55%) compared with placebo (39%; both P < 0.0001). Proportions of patients with shifts of 1 to 3 grades down in MIDAS or HIT-6 disability severity were significantly greater with quarterly and monthly fremanezumab compared with placebo (all P < 0.0001).

Conclusion
Fremanezumab demonstrated clinically meaningful improvements in disability severity in this pooled analysis.

Trial registrations
HALO CM, NCT02621931; HALO EM, NCT02629861; FOCUS, NCT03308968.
Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences
Authors: Oku Yoshitaka 
Published: August 2022

AbstractThe breathing process possesses a complex variability caused in part by the respiratory central pattern generator in the brainstem; however, it also arises from chemical and mechanical feedback control loops, network reorganization and network sharing with nonrespiratory motor acts, as well as inputs from cortical and subcortical systems. The notion that respiratory fluctuations contain hidden information has prompted scientists to decipher respiratory signals to better understand the fundamental mechanisms of respiratory pattern generation, interactions with emotion, influences on the cortical neuronal networks associated with cognition, and changes in variability in healthy and disease-carrying individuals. Respiration can be used to express and control emotion. Furthermore, respiration appears to organize brain-wide network oscillations via cross-frequency coupling, optimizing cognitive performance. With the aid of information theory-based techniques and machine learning, the hidden information can be translated into a form usable in clinical practice for diagnosis, emotion recognition, and mental conditioning.
Hepatitis B, C, and delta in the general population in Mayotte: hepatitis B as a major public health concern
Authors: Brouard Cécile , Parenton Fanny , Youssouf Hassani , Chevaliez Stéphane , Gordien Emmanuel , Jean Maxime , Bruyand Mathias , Vaux Sophie , Lot Florence , Ruello Marc ,   Unono Wa Maore group, Fleury Marion , Richard Jean-Baptiste , Solet Jean-Louis , Filleul Laurent , Jezewski-Serra Delphine , Chesneau Julie 
Published: August 2022

Abstract
Background
Located in southwestern Indian Ocean, Mayotte is a French territory, with a very specific demographic, social and health context. To date, epidemiological data on infections by hepatitis B (HBV), C (HCV), and delta (HDV) viruses in Mayotte have been sparse. We aimed to estimate, in the 15–69-year-old general population living in Mayotte, the prevalence of infections by hepatitis B (HBV), C (HCV), and delta (HDV) viruses and the distribution of HBV status: current infection with positive HBs antigen (Ag); resolved infection with positive HBc antibodies and negative HBsAg; immunisation by vaccination with only positive HBs antibodies; and no infection/no immunisation with negative markers. We also described the characteristics of infected people and assessed the determinants of lifetime HBV infection.

Methods
The Unono Wa Maore survey, implemented in a random sample of the general population in 2018–2019, consisted of an at-home collection of epidemiological data and venous blood samples. Detection of hepatitis B, C, and delta serological and molecular markers was performed.

Results
Among 5207 eligible people, 4643 responded to the questionnaire (89.2%), with 2917 being tested for HBV and HCV (62.8%). Estimated HBV status was as follows: current infection 3.0% (95% confidence interval [CI]: 2.3–3.9%) (n = 76); resolved infection 27.8% (95% CI: 25.8–29.9); immunisation by vaccination 27.7% (95% CI: 25.9–29.7); and no infection/no immunisation 41.5% (95% CI: 39.3–43.7). One participant was positive for HDV antibodies (Ab) (0.65%) with a negative HDV-RNA viral load. The risk of lifetime HBV infection was higher in men (adjusted prevalence ratio (aPR): 1.55, 95% CI: 1.29–1.89); in people aged 30–49 years (aPR: 3.83, 95% CI: 1.49–9.81) or 50–69 years (aPR: 4.52, 95% CI: 1.77–11.53) compared to those under 20; in individuals who reported no condom use during their first sexual intercourse (aPR: 1.46, 95% CI: 1.01–2.14); and in those living in Dembeni-Mamoudzou (aPR: 1.40, 95% CI: 1.09–1.80) compared to the West-Centre of Mayotte. Finally, six individuals were positive for HCV antibodies (0.21%), including three positive for HCV RNA.

Conclusions
Mayotte is an area of intermediate endemicity for HBV and low endemicity for HCV and HDV. With a prevalence of HBsAg 10 times higher than in mainland France, a high proportion of people susceptible to HBV infection, and a demographic, health, and social context that may favour its transmission, hepatitis B is a major public health concern in Mayotte.