bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEPLS Well-Being as a Vision: Co-managing for Diversity, Connectivity, and Adaptive Capacity in Xinshe Village, Hualien County, Chinese Taipei
Authors: Karimova Paulina G. , Yan Shao-Yu , Lee Kuang-Chung 
Published: June 2022

AbstractSince 2016, a 600 hectare “ridge-to-reef” watershed of the Jialang River in Xinshe Village, Hualien County, Chinese Taipei, has been adaptively co-managed by a multi-stakeholder platform uniting two indigenous tribes (Fuxing and Xinshe) and four regional government agencies subordinate to the Council of Agriculture. The Five Perspectives of the Satoyama Initiative formed the core of the Xinshe SEPLS adaptive co-management model. The year 2020 marked the end of the short-term phase (2016–2019) and a transition period to the midterm phase (2021–2026) of the Xinshe “Forest-River-Village-Ocean” Eco-Agriculture Initiative (the Xinshe Initiative). How could the midterm management of the Xinshe Initiative most effectively enhance the Xinshe SEPLS well-being by 2026? To answer this question, we developed a set of 20 Localised Indicators of Resilience in the Xinshe SEPLS, analysed the concept of SEPLS well-being on the basis of the 5R conceptual framework (“ridge-to-reef”, risks, resources, and resilience), and contributed the results of our study to the midterm action plan of the Xinshe Initiative.
“To Take Care of the Land Means Taking Care of Ourselves”: Local Perceptions on Human and Environmental Health in a High Agro-Biodiversity Landscape in the Yucatan Peninsula
Authors: Méndez-López María Elena , Cepeda-González María Fernanda , Rodríguez-Robayo Karla Juliana , Juárez-Téllez Lilian , Rivera-De Velasco Mariana , Peralta-Blanco Rosa Martha , Chan-Chuc Nicolás , Serrano-Ysunza Andrea A. , Riveros-Cañas R. Antonio , Sánchez-Siordia Oscar G. , Proust Sebastien 
Published: June 2022

AbstractThe Forest and Milpa Landscape (FML) is a territory comprising 64 municipalities in the Yucatan Peninsula where the rainforest and the milpa system coexist. The ecosystems that predominate in the FML are sub-deciduous and subtropical evergreen forests, which represent an essential carbon reservoir worldwide. The use of natural resources for food security of FML families is associated with the milpa, which is a system that depends on the rainfall and the soil’s ability to retain water. Within the framework of the 2020–2030 Country Strategy of the GEF Small Grants Programme (SGP), 20 indicators associated with the FML’s resilience were evaluated through a participatory approach. The methodological route consisted of adapting the Toolkit for the Indicators of Resilience in Socio-ecological Production Landscapes and Seascapes (SEPLS). A topic that generated much concern among participants was human health. The reflection generated around this indicator recognised problems associated with water contamination by agrochemicals and changes in diet, resulting in recurrent diseases, such as diabetes, hypertension, and obesity. The solutions proposed by the small producers are linked to the sustainable management of ecosystems and education on values towards traditional and agroecological food production.
Existence of Zero-Damped Quasinormal Frequencies for Nearly Extremal Black Holes
Authors: Joykutty Jason 
Published: June 2022

AbstractIt has been observed that many spacetimes which feature a near-extremal horizon exhibit the phenomenon of zero-damped modes. This is characterised by the existence of a sequence of quasinormal frequencies which all converge to some purely imaginary number $$i\alpha $$

i
α

in the extremal limit and cluster in a neighbourhood of the line $${{\,\mathrm{Im}\,}}s=\alpha $$

Im

s
=
α

. In this paper, we establish that this property is present for the conformal Klein–Gordon equation on a Reissner–Nordström–de Sitter background. This follows from a similar result that we prove for a class of spherically symmetric black hole spacetimes with a cosmological horizon. We also show that the phenomenon of zero-damped modes is stable to perturbations that arise through adding a potential.
The space of homogeneous probability measures on $$\overline{\Gamma \backslash X}^S_\mathrm{max}$$ is compact
Authors: Daw Christopher , Gorodnik Alexander , Ullmo Emmanuel 
Published: June 2022

AbstractIn this paper we prove that the space of homogeneous probability measures on the maximal Satake compactification of an arithmetic locally symmetric space is compact. As an application, we explain some consequences for the distribution of weakly special subvarieties of Shimura varieties.
Bott–Chern and $$\bar{\partial }$$ harmonic forms on almost Hermitian 4-manifolds
Authors: Holt Tom 
Published: June 2022

AbstractWe prove that on a compact almost Hermitian 4-manifold the space of $${\bar{\partial }}$$

∂

¯

-harmonic (1, 1)-forms always has dimension $$h_{{\bar{\partial }}}^{1,1} = b_- +1$$

h

∂

¯

1
,
1

=

b
-

+
1

or $$b_-$$

b
-

, whilst the space of Bott–Chern harmonic (1, 1)-forms always has dimension $$h_{BC}^{1,1} = b_- +1$$

h

BC

1
,
1

=

b
-

+
1

. We also perform calculations of $$h^{2,1}_{BC}$$

h

BC

2
,
1

and $$h^{1,2}_{BC}$$

h

BC

1
,
2

on the Kodaira–Thurston manifold, thereby providing a full account of when $$h^{p,q}_{BC}$$

h

BC

p
,
q

is or is not invariant of the choice of almost Hermitian metrics. Finally, we introduce a decomposition of the space of $$L^2$$

L
2

functions on all torus bundles over $$S^1$$

S
1

, which has proven useful for solving linear PDEs, and we demonstrate its use in the calculation of $$h^{p,q}_{{\bar{\partial }}}$$

h

∂

¯

p
,
q

.
CXCR4-targeted theranostics in oncology
Authors: Buck Andreas K. , Serfling Sebastian E. , Lindner Thomas , Hänscheid Heribert , Schirbel Andreas , Hahner Stefanie , Fassnacht Martin , Einsele Hermann , Werner Rudolf A. 
Published: June 2022

AbstractA growing body of literature reports on the upregulation of C-X-C motif chemokine receptor 4 (CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for molecular imaging and endoradiotherapy in a theranostic setting. For instance, the CXCR4-targeting positron emission tomography (PET) agent [68 Ga]PentixaFor has been proven useful for a comprehensive assessment of the current status quo of solid tumors, including adrenocortical carcinoma or small-cell lung cancer. In addition, [68 Ga]PentixaFor has also provided an excellent readout for hematological malignancies, such as multiple myeloma, marginal zone lymphoma, or mantle cell lymphoma. PET-based quantification of the CXCR4 capacities in vivo allows for selecting candidates that would be suitable for treatment using the theranostic equivalent [177Lu]/[90Y]PentixaTher. This CXCR4-directed theranostic concept has been used as a conditioning regimen prior to hematopoietic stem cell transplantation and to achieve sufficient anti-lymphoma/-tumor activity in particular for malignant tissues that are highly sensitive to radiation, such as the hematological system. Increasing the safety margin, pretherapeutic dosimetry is routinely performed to determine the optimal activity to enhance therapeutic efficacy and to reduce off-target adverse events. The present review will provide an overview of current applications for CXCR4-directed molecular imaging and will introduce the CXCR4-targeted theranostic concept for advanced hematological malignancies.
A 10-year retrospective observational study on the utility and prescription standards of dexamethasone in pediatric neuro-oncosurgery in a tertiary care center
Authors: Chumbala Na Ayudhaya Anutra , Morrison Scott R. , Kaliaperumal Chandrasekaran , Gallo Pasquale 
Published: June 2022

Abstract
Object
This study aimed to retrospectively assess dexamethasone utility in pediatric CNS tumor patients over a 10-year period, to better understand dosing variability, and highlight optimal practice.

Methods
All pediatric CNS tumor cases managed operatively for a 10-year period at a single center were reviewed. Information was gathered on demographics, dexamethasone doses, course durations, weaning regimes, PPI co-prescription, adverse events, and route of administration. Comparison within these groups was analyzed through use of statistical testing.

Results
One hundred twenty-seven patients received 193 dexamethasone courses. Median age was 7 years, with a median weight of 27.9 kg. Most common tumor type was astrocytoma (24.8%). Median daily dose was 8 mg, with twice-daily dosing most common. Median course duration was 8 days, ranging from 1 to 1103 days. Median weaning duration was 11.5 days. Daily dose was not correlated with patient weight and the median daily dose per kg was 0.2319 mg/kg. Incidence of adverse effects was 14.5% across all course lengths, with weight gain most common. The short-term course duration (<14 days) had the lowest adverse event incidence, with direct correlation between course length and adverse effect incidence. Dexamethasone dose per kg was not significantly different between patients with and without adverse effects. No relationship was noted between adverse effects incidence and administration route (intravenous compared to oral). 64.2% of patients received concurrent PPI with 35.8% receiving no PPI, with 1 gastrointestinal side effect noted in the PPI-receiving population.

Conclusions
Large variation was seen in practice, with prescriptions appearing based on clinician preference and symptom severity rather than patient age or weight. Future guidelines should consider lower dose regimens than are currently presented with less frequent dosing as these may benefit quality of life. Weaning period can be relatively rapid for most patients, taking place in 2–3 days. PPI co-prescription does not seem to add significant benefit. We recommend using a standardized guideline of 0.2 mg/kg/day (max 8 mg/day) given OD or BD, with PPI cover where necessary. For acute presentations, we recommend limiting dexamethasone treatment to <14 days. These recommendations can be adjusted for individual cases to yield optimal results.
A journey towards the forbidden zone: a new, cold, UHP unit in the Dora-Maira Massif (Western Alps)
Authors: Manzotti Paola , Schiavi Federica , Nosenzo Francesco , Pitra Pavel , Ballèvre Michel 
Published: June 2022

AbstractThe distribution of ultrahigh-pressure metamorphism (UHP) at the scale of a mountain belt is of prime importance for deciphering its past subduction history. In the Western Alps, coesite has been recognized in the southern Dora-Maira Massif, in the lens-shaped Brossasco-Isasca Unit, but has not been found up to now in the other parts of the massif. We report the discovery of a newUHPunit in the northern Dora-Maira Massif (Western Alps), named Chasteiran Unit. It is only a few tens of metres thick and consists of graphite-rich, garnet–chloritoid micaschists, whose protoliths may be black shales of Silurian age. Garnet inclusions (chloritoid, rutile) and its growth zoning allow to precisely model theP–Tevolution. Coesite crystals, which are pristine or partially transformed to palisade quartz occur as inclusions in the garnet outer cores. According to thermodynamic modelling, garnet displays a continuous record of growth during the prograde increase inPandT(25–27 kbar 470–500 °C) (stage 1), up to the coesite stability field (27–28 kbar 510–530 °C) (stage 2), as well as sub-isothermal decompression of about 10 kbar (down to 15 kbar 500–515 °C) (stage 3). The main regional, composite, foliation, marked by chloritoid and rutile, began to develop during this stage, and was then overprinted by chlorite–ilmenite (stage 4). The Chasteiran Unit is discontinuously exposed in the immediate hangingwall of the Pinerolo Unit, and it is located far away from, and without physical links to the classicUHPBrossasco-Isasca Unit. Moreover, it records a different, much colder,P–Tevolution, showing that different slices were detached from the downgoing subduction slab. The Chasteiran Unit is the fourth and the coldest AlpineUHPunit known so far in the entire Alpine belt. ItsP–Tconditions are comparable to the ones of the Tian Shan coesite–chloritoid-bearing rocks.
Core values of patients with advanced cancer considering participation in an early-phase clinical trial: a qualitative study
Authors: van Gurp Jelle L. P. , van Lent Liza G. G. , Stoel Nicole , van der Rijt Carin C. D. , de Jonge Maja J. A. , Pulleman Saskia M. , van Weert Julia C. M. , Hasselaar Jeroen 
Published: June 2022

Abstract

Objective
This article identifies the core values that play a role in patients’ decision-making process about participation in early-phase clinical cancer trials.

Methods
Face-to-face, semi-structured serial interviews (n = 22) were performed with thirteen patients with advanced cancer recruited in two Dutch specialized cancer centers. In a cyclic qualitative analysis process, open and axial coding of the interviews finally led to an overview of the values that are woven into patients’ common language about cancer and clinical trials.

Results
Six core values were described, namely, acceptance creates room for reconsideration of values, reconciliation with one’s fate, hope, autonomy, body preservation, and altruism. Previously found values in advanced cancer, such as acceptance, hope, autonomy, and altruism, were further qualified. Reconciliation with one’s fate and body preservation were highlighted as new insights for early-phase clinical cancer trial literature.

Conclusions
This article furthers the understanding of core values that play a role in the lives and decision-making of patients with advanced cancer who explore participation in early-phase clinical cancer trials. These values do not necessarily have to be compatible with one another, making tragic choices necessary. Understanding the role of core values can contribute to professional sensitivity regarding what motivates patients’ emotions, thoughts, and decisions and help patients reflect on and give words to their values and preferences. It supports mutual understanding and dialog from which patients can make decisions according to their perspectives on a good life for themselves and their fellows in the context of participation in an early-phase clinical cancer trial.
Distance to home does not influence treatment success during and after inpatient treatment in adolescents with anorexia nervosa
Authors: Meule Adrian , Kolar David R. , Naab Silke , Voderholzer Ulrich 
Published: June 2022

AbstractCurrent treatment guidelines recommend that inpatients with eating disorders—particularly adolescents with anorexia nervosa—should receive treatment at facilities within close distance to their home. However, whether distance to home actually influences short- and long-term treatment outcome in adolescents with anorexia nervosa has not been investigated yet. We re-analyzed data at admission, discharge, and 1-year follow up from a recent study with N = 142 female, adolescent inpatients with anorexia nervosa. Distance to home did not moderate changes in body weight, eating disorder symptoms, depressive symptoms, compulsive exercise, and life satisfaction. This is the first analysis that indicates that specialized inpatient treatment for adolescents with anorexia nervosa is effective both close to and away from home.
Sex and gender differences in migraines: a narrative review
Authors: Rossi Maria Francesca , Tumminello Antonio , Marconi Matteo , Gualano Maria Rosaria , Santoro Paolo Emilio , Malorni Walter , Moscato Umberto 
Published: June 2022

Abstract

Introduction
Gender medicine is a new medical approach aimed at the study of the differences between women and men in terms of prevention, diagnosis, and the outcome of all diseases. Migraines are among these. They represent the most common neurological illness; they are most prevalent in adults between 20 and 50 years of age and are three to four times more frequent in woman than in men. Affecting people in working age, migraines are a problem that strongly impacts the psychophysical health and productivity of workers, regardless of the specific job task they have.

Methods
A narrative review was performed, searching for the most relevant articles describing gender differences in people suffering from migraines, and particularly in workers.

Results
Migraine global prevalence is 20.7% in women and 9.7% in men whereas prevalence in Italy is 32.9% for women and only 13.0% for men. This difference is partly explained by hormonal differences, as well as by differences in brain structure, genetic polymorphisms and neuronal pathways. Sex differences may also play a role in the progression from episodic to chronic migraine. In workers, migraines are mostly associated with strenuous physical work in men, whilst migraines triggered by night shifts, lack of sleep, or irregular sleep patterns are more common in women.

Conclusions
To this day, the reasons of sex/gender disparity for migraine are still obscure. However, migraines, chronic migraine in particular, have a negative impact on the lives of all individuals affected by this disease, but particularly in women in which family cares and working activity are often superimposed. Migraine prevention strategies should be planned in workers through the occupational health physician.
Retraction Maps: A Seed of Geometric Integrators
Authors: Barbero-Liñán María , de Diego David Martín 
Published: June 2022

AbstractThe classical notion of retraction map used to approximate geodesics is extended and rigorously defined to become a powerful tool to construct geometric integrators and it is called discretization map. Using the geometry of the tangent and cotangent bundles, we are able to tangently and cotangent lift such a map so that these lifts inherit the same properties as the original one and they continue to be discretization maps. In particular, the cotangent lift of a discretization map is a natural symplectomorphism, what plays a key role for constructing geometric integrators and symplectic methods. As a result, a wide range of (higher-order) numerical methods are recovered and canonically constructed by using different discretization maps, as well as some operations with Lagrangian submanifolds.
A large family with MSH3-related polyposis
Authors: Aelvoet Arthur S. , Hoekman Daniël R. , Redeker Bert J. W. , Weegenaar Jitske , Dekker Evelien , van Noesel Carel J. M. , Duijkers Floor A. M. 
Published: June 2022

AbstractBiallelic MSH3 germline variants are a rare cause of adenomatous polyposis as yet reported in two small families only. We describe the phenotype of a third family, the largest thus far, with adenomatous polyposis related to compound heterozygous MSH3 pathogenic variants. The index patient was a 55-years old male diagnosed with rectal cancer and adenomatous polyposis (cumulatively 52 polyps), with a family history of colorectal polyposis with unknown cause. Next-generation sequencing and copy number variation analysis of a panel of genes associated with colorectal cancer and polyposis revealed compound heterozygous germline pathogenic variants in the MSH3 gene. Nine out of 11 siblings were genotyped. Three siblings carried the same compound heterozygous MSH3 variants. Colonoscopy screening showed predominantly right-sided adenomatous polyposis in all compound heterozygous siblings, with a cumulative number of adenomas ranging from 18 to 54 in an average of four colonoscopies, and age at first adenoma detection ranging from 46 to 59. Microsatellite analysis demonstrated alterations at selected tetranucleotide repeats (EMAST) in DNA retrieved from the rectal adenocarcinoma, colorectal adenomas as well as of normal colonic mucosa. Gastro-duodenoscopy did not reveal adenomas in any of the four patients. Extra-intestinal findings included a ductal adenocarcinoma in ectopic breast tissue in one female sibling at the age of 46, and liver cysts in three affected siblings. None of the three heterozygous or wild type siblings who previously underwent colonoscopy had adenomatous polyposis. We conclude that biallelic variants in MSH3 are a rare cause of attenuated adenomatous polyposis with an onset in middle age.
The impact of selected input and output factors on measuring research efficiency of university research fields: insights from a purpose-, field-, and method-specific perspective
Authors: Ahn Heinz , Clermont Marcel , Langner Julia 
Published: June 2022

AbstractThe measurement of universities’ efficiency is gaining importance due to the increasing competitive pressure. As the results of such a measurement depend especially on the included input and output factors, it is essential to select them carefully to generate valid results. Against this background, we analyze the impact of including selected input and output factors on measuring the research efficiency of university research fields by applying best-practice frontier benchmarking methods. Based on a standard scenario, we consider the additional inclusion of expenditures, research grants, and bibliometric indicators. In doing so, we take account of different research fields as well as methods and purposes of measuring efficiency. Regarding the latter aspect, we distinguish between the computed efficiency degrees and the resulting ranking. We observe that the additional input and output factors have a quite heterogeneous impact on the respective evaluation criteria. The corresponding findings are relatively robust with respect to the research fields and methods considered. Our results provide guidance for evaluators as well as university and political decision-makers.
Assessment method of the sea turtle-nesting habitat of small reef islands
Authors: Garcin Manuel , Vende-Leclerc Myriam , Read Tyffen , Oremus Marc , Bourgogne Hugo 
Published: June 2022

AbstractThe coral islets in the lagoon of New Caledonia are a major breeding and nesting site for various species. Many species reproduce and nest there, whether they are Chelonians (green turtles and loggerhead turtles), offshore seabirds (Procellariidae: shearwaters, petrels …) or more coastal (Laridae: terns, ospreys …) or sqamata (sea krait: Laticauda saintgironsi and Laticauda laticaudata). These species are dependent on the persistence of the islets in which they find the necessary conditions for nesting. Previous research has shown that these islets can evolve very rapidly at a yearly to decadal timescale. These geomorphological evolutions lead to surface area variations as well as geomorphological, topographical and land cover changes. These changes may lead to an evolution of the sea turtle nesting habitat: reduction of suitable areas for nesting and changes of the accessibility to the nesting sites. The goal of our work is to propose a method that allows to determine, map and quantify the more or less favourable character of the islets coasts to the nesting of sea turtles. Using several parameters, an indicator of the nesting attractiveness of coast is constructed and mapped. This method was applied to 13 coral islets in the southern lagoon of New Caledonia. Comparison of the results with the location of sea turtle nests acquired during the 2020 campaign attest the relevance of the method.