bluuebunny/crossref_metadata_2025_split huggingface dataset:
Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for
Neurodegenerative Disorders
Authors: Catarzi Daniela , Varano Flavia , Vigiani Erica , Lambertucci Catia , Spinaci Andrea , Volpini Rosaria , Colotta Vittoria 
Published: March 2022

Abstract:
Casein kinase 1 (CK1) belongs to the serine-threonine kinase family and is expressed
in all eukaryotic organisms. At least six human isoforms of CK1 (termed α, γ1-3,
δ and ε) have been cloned and characterized. CK1δ isoform modulates several physiological
processes, including DNA damage repair, circadian rhythm, cellular proliferation and
apoptosis. Therefore, CK1δ dysfunction may trigger diverse pathologies, such as cancer,
inflammation and central nervous system disorders. Overexpression and aberrant activity
of CK1δ have been connected to hyperphosphorylation of key proteins implicated in the
development of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases
and Amyotrophic Lateral Sclerosis. Thus, CK1δ inhibitors have attracted attention
as potential drugs for these pathologies and several compounds have been synthesized or
isolated from natural sources to be evaluated for their CK1δ inhibitory activity. Here we
report a comprehensive review on the development of CK1δ inhibitors, with a particular
emphasis on structure-activity relationships and computational studies, which provide
useful insight for the design of novel inhibitors.
Sex Differences in Therapies for Heart Failure
Authors: Miličić Davor , Bergami Maria , Pavasović Saša 
Published: March 2022

Abstract:
Heart failure (HF) is a common cause of morbimortality with different etiopathogenesis and prognosis
between men and women. This review provides a brief overview of gender-based differences in response to
pharmacological therapies of heart failure with or without reduced ejection fraction (EF). It focuses on the differences
in therapy outcomes with angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor
blockers (ARBs), angiotensin neprilysin inhibitors (ARNI), beta-adrenergic blockers, mineralocorticoid/
aldosterone receptor antagonists, diuretics, ivabradine and digoxin. The baseline data originate from randomised
controlled trials (RCTs) and large registries. We conclude that current guidelines recommending similar
therapeutic approaches for both men and women are appropriate, while additional consideration should be given
to different approaches regarding the use of ARBs, ACEi, and digoxin. Based on the available data, the
ARBs might be considered a first-line therapy of HR for women instead of ACEi. Moreover, female patients
should have stricter digoxin monitoring due to higher sensitivity and increased risk of complications. Finally,
women are underrepresented in current clinical trials, and therefore future trials should aim to balance the gender
recruitment disparity allowing sub-group analysis and comparisons between genders to guide individualised
therapeutic strategies and appropriately targeted preventative steps.
Biheterocyclic Coumarins: A Simple Yet Versatile Resource for Futuristic Design and
Applications in Bio-molecular and Material Chemistry
Authors: Anand Ashish , Khanapurmath Netravati , Kulkarni Manohar V. , Guru Row Tayur N. 
Published: March 2022

Abstract:
Coumarin derivatives occur widely in nature and are a part of both traditional and
modern advancements in synthesis and application. To date, thousands of coumarin derivatives
have been synthesized in lab or isolated from plant and marine life. These are essentially 2-
pyrone core fused with a benzene ring and belong to the family of aromatic oxygen heterocycles.
Coumarin in conjugation with various other heterocyclic systems has provided a robust
framework for tuning the properties associated with the parent structure. The frequency of
reports has increased for these biheterocyclic systems from the mid twentieth century. Biheterocyclic
coumarins have also attracted the attention of many organic and pharmaceutical chemists
as these systems serve as useful synthetic intermediates in the synthesis of analogs of existing
drugs. Their application in the design of effective organocatalysts and chemosensors has
further extended their versatility. Coumarin biheterocyclic core is utilized in the rational design and tuning of complex
molecular entities in molecular recognition, analytical and material chemistry. This review highlights the advancements
in the synthesis and applications of coumarin-linked nitrogen, oxygen, and sulfur heterocycles. It also
provides an account of five-, six-, and seven-membered heterocyclic rings linked to coumarin core. Critical physicochemical
properties coupled with their application will make this review useful for synthetic chemists and drug
discovery labs. A comprehensive spectrum of literature in this review will facilitate further development of biheterocycles
along with their promising applications in the future.
Which Metrological Index, the BASMI or EDASMI, is Best Correlated
with Disease-Related Parameters in Spondylarthritis Patients?
Authors: Triki Wafa , Maatallah Kaouther , Ferjani Hanene , Nessib Dorra Ben , Kaffel Dhia , Hamdi Wafa 
Published: March 2022

Objective:
This study aimed at comparing the Edmonton Ankylosing Spondylitis Metrol-ogy Index (EDASMI) and Bath Ankylosing Spondylitis Metrology Index (BASMI) to determine which of the two is best correlated with disease-related parameters in axial spondyloarthritis (axSpA) patients.

Methods:
A cross-sectional study was carried out involving 86 patients with radiographic axSpA. Sociodemographic data, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Ankylosing Spondylitis Disease Activity Score (ASDAS), the Bath Ankylosing Spondylitis Func-tional Index (BASFI), and the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire were applied. Spinal mobility was assessed by two indices: the BASMI and the EDASMI. Structural damage of the spine was also evaluated by two indices: the Bath Ankylosing Spondylitis Radiology Index (BASRI) and the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS).

Results:
Eighty-six patients with an average age of 43.21 ± 11.43 years (20-79) were included. Im-paired spinal mobility, which corresponds to higher BASMI scores, was correlated with prolonged disease duration (p < 0.01, r = 0.310), higher ASDAS-CRP (p < 0.001, r = 0.386), severe functional disability on the BASFI (p < 0.01, r = 0.505) and poorer quality of life according to the ASQoL (p < 0.01, r = 0.369). However, the EDASMI score did not correlate with any disease parameter. The BASMI was correlated with the total BASRI (p < 0.01, r = 0.634) and mSASSS (p < 0.01, r = 0.388). Unlike the BASMI, the EDASMI was neither correlated with the BASRI (p = 0.520, r = 0.245) nor the mSASSS (p = 0.252, r = -0.120).

Conclusion:
Our results indicate that among the studied metrological indices, the BASMI is more contributory since it is correlated with clinical disease parameters and structural damage, unlike the EDASMI.
Preliminary Observations on Soaps Increasing Slipperiness and Bathroom Injuries
Authors: Anzelc Madison J. , Burkhart Craig G. , Black Curt 
Published: March 2022

Every year, about 235,000 people over the age of 15 suffer from falls in the bathroom and visit the emergency room, with 37.3% being related to bathing or showering. While various approaches exist to minimize these risks, the core etiology of slipping is often overlooked by consumers, producers, and physicians.
The foremost contributor to the cause of slipping in the shower or bath is the use of soaps and bathing products. These products can accumulate on the floor of the shower or tub and consequently alter its surface properties, such as decreasing friction or hindering the body’s natural ability to sense position. Two of the major contributors to this increased slipperiness found in many bath products are oils and surfactants. This brings to light the question of using less dangerous substances in the products, as well as educating the consumer about the inclusion of properties that predispose to slipping. Overall, the consumers’ safety needs to be considered when products are created and marketed.
With such a high incidence of slipping occurrences related to bathing or showering, there is a need for more research in this specific area. The high-risk environment due to soaps, coupled with the lack of research regarding this topic, warrants further evaluation from the product producers. It is imperative that further research is required on the specific chemical properties and their effect on surfaces and how they contribute to consumers’ safety.
Withdrawn: Variations in Altered Global Gene Expression caused by
Topoisomerase II Poisons Assessed with Reference to Differences in DNA
Binding
Authors: Zihlif Malek , Catchpoole Daniel R. , Stewart Bernard W. , Wakelin Laurence P.G. 
Published: March 2022

The article has been withdrawn at the request of the authors of the journal Current Molecular Pharmacology.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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of their article is transferred to the publishers if and when the article is accepted for publication.
Green Synthesis of Copper Oxide Nanoparticles Using Eichhornia Crassipes Leaf Extract, its Antibacterial and Photocatalytic Activities
Authors: Tadele Kirubel T. , Saligedo Tamene S. , Muleta Gutta G. , Tsega Tilahun W. 
Published: March 2022

Background:Green approach is among the preferable methods for metal-based nanoparticles synthesis due to its simplicity, cost-effectiveness, ecofriendly reagents, and a broad spectrum of biological activities. This study aimed to synthesize copper oxide nanoparticles using Eichhornia Crassipes (Water hyacinth) leaf extract in an eco-friendly manner.Methods:Copper oxide nanoparticles were synthesized using Eichhornia Crassipes (Water hyacinth) leaf extract. The effect of different parameters, such as concentration of the plant extract, time, light, and pH, on the formation of the nanoparticles was investigated. The synthesized nanoparticles were characterized by UV-Vis, FTIR, TEM, and P-XRD spectroscopic techniques. The antibacterial and photocatalytic activities of the synthesized copper oxide nanoparticles were determined.Results:Powder X-Ray diffraction analysis (PXRD) showed that the copper oxide nanoparticles have a size of 9.1 nm. Transmission electron microscopy (TEM) images displayed that the Nps were spherical, polydispersed, and well crystallized. The nanoparticles displayed good antibacterial activity against Escherichia coli, Staphylococcus, Bacillus subtilis, and Salmonella typhi, with the highest activity against Salmonella typhi.Conclusion:Copper oxide nanoparticles were effectively synthesized, and secondary metabolites, such as flavonoids, alkaloids, tannins, and phenols, acted as both capping and stabilizing agents. The good antibacterial and photocatalytic activities of the synthesized nanoparticles indicated their potential for applications in pharmacology and environmental protections, respectively. However, the product needs further investigation to enhance its antibacterial potential for efficient pharmacological application.
Clustering Diagnoses From 58 Million Patient Visits in Finland Between 2015 and 2018
Authors: Fränti Pasi , Sieranoja Sami , Wikström Katja , Laatikainen Tiina 
Published: March 2022

Background
Multiple chronic diseases in patients are a major burden on the health service system. Currently, diseases are mostly treated separately without paying sufficient attention to their relationships, which results in the fragmentation of the care process. The better integration of services can lead to the more effective organization of the overall health care system.

Objective
This study aimed to analyze the connections between diseases based on their co-occurrences to support decision-makers in better organizing health care services.

Methods
We performed a cluster analysis of diagnoses by using data from the Finnish Health Care Registers for primary and specialized health care visits and inpatient care. The target population of this study comprised those 3.8 million individuals (3,835,531/5,487,308, 69.90% of the whole population) aged ≥18 years who used health care services from the years 2015 to 2018. They had a total of 58 million visits. Clustering was performed based on the co-occurrence of diagnoses. The more the same pair of diagnoses appeared in the records of the same patients, the more the diagnoses correlated with each other. On the basis of the co-occurrences, we calculated the relative risk of each pair of diagnoses and clustered the data by using a graph-based clustering algorithm called the M-algorithm—a variant of k-means.

Results
The results revealed multimorbidity clusters, of which some were expected (eg, one representing hypertensive and cardiovascular diseases). Other clusters were more unexpected, such as the cluster containing lower respiratory tract diseases and systemic connective tissue disorders. The annual cost of all clusters was €10.0 billion, and the costliest cluster was cardiovascular and metabolic problems, costing €2.3 billion.

Conclusions
The method and the achieved results provide new insights into identifying key multimorbidity groups, especially those resulting in burden and costs in health care services.
Resenha
Authors: Yakini Michel 
Published: March 2022

Resenha do livro: Sarau Elo da Corrente 13 anos: tambor, território e oralidades. Organização: Coletivo Literário Sarau Elo da Corrente. São Paulo, Avangi Cultural, 2021, obra comemorativa do Coletivo Literário Sarau Elo da Corrente, atuante desde 2007, nas periferias de São Paulo, que reúne textos dos organizadores; de pesquisadores; além de poesias, prosas curtas e fotografias que ilustram a história do coletivo.
Educação remota e pandemia em close-up
Authors: Dias Rosimeri de Oliveira , Pinto Liliana  Secron , Busquet Líbia 
Published: March 2022

Este é um artigo tecido à seis mãos, por meio do encontro e conversas entre três professoras da rede pública de ensino, duas da escola básica e uma da universidade. Esta tessitura conceitua um encontro como aquilo que ativa um campo problemático, princípio de uma formação inventiva de professores. Colocamos em análise e em intervenção uma educação remota, convocada pelos cenários pandêmicos do presente, e o seu plano close-up, que elimina o corpo em sua totalidade como enunciador. No enquadre de uma tela - de computador e/ou celular – a educação vira foco evidenciando um processo de exclusão em massa, tanto do corpo, como de um quantitativo de estudantes e de professores que não possuem acesso ao mundo remoto. Para tanto, o trabalho se divide em três cenas em close-up, a saber: Cena 1: Pandemia e pandemônio: vai passar!(?); Cena 2: espaços outros e as heterotopias: em uma ofegante epidemia, um pouco de ar para não sufocar; Cena 3/Epílogo: brechas de uma formação inventiva de professores: a evolução da liberdade. A aposta conceitual e metodológica proposta apresenta tomadas que compõem as cenas e funcionam como propagadores da dimensão crítica e de resistência para afirmar modos autogestionários e inventivos de formar que ligam conhecer e viver à um ethos – uma política para a produção de vidas livres, raridades em tempos de educação e controle remotos.
ARANG AKTIF SERBUK GERGAJI KAYU JATI (TECTONA GRANDIS L.F) SEBAGAI BAHAN ADSORBEN PADA PEMURNIAN MINYAK JELANTAH
Authors: Nusratullah Nusratullah , Aminah Sitti 
Published: March 2022

Used cooking oil can increase the potential for cancer in the body. Therefore, used cooking oil processing efforts were made to improve its quality by using activated charcoal adsorbent of Tectona Grandis L. F sawdust. This study aimed to improve the quality of used cooking oil through refinign by using charcoal adsorbent of Tectona Grandis L.f sawdust. used cooking oil samples were obtained from Ogoamas 1 Village, Sojol Utara District, Donggala Regency. Based on the results of testing the quality of the oil obtained, the water content was 0.22%, free fatty acid content was 0.25% peroxide number was 1.83 meq / Kg, the iodic number was 45, specific gravity was 0.900 g / mL and oil color clear oil with absorbance value was 0.031 A. Based on the quality of several parameters of cooking oil using activated charcoal of Tectona Grandis L.f sawdust, it has fulfilled the quality requirements of cooking oil according to SNI 3741-1995.
Tax-Rate Biases in Tax Decisions: Experimental Evidence
Authors: Amberger Harald J. , Eberhartinger Eva , Kasper Matthias 
Published: March 2022

ABSTRACT
This study investigates biases in tax decisions. In a series of four laboratory experiments with 303 students and 62 tax professionals, we document a systematic tax-rate bias in decisions under time constraints. Specifically, decision makers overestimate the relevance of less complex tax-rate information compared to more complex tax-base information. This behavior leads to suboptimal tax decisions. We also find that decision making, on average, is unaffected by professional experience: Students and tax professionals are similarly prone to tax-rate bias. However, senior tax professionals are more rationally inattentive. These decision makers are less likely to exhibit a tax-rate bias when exhibiting such bias is relatively costly. Overall, our findings suggest that resource constraints impede the use of complex tax-base information, which results in suboptimal tax decisions. Interviews with senior tax professionals indicate potential for tax-rate biases in real-world tax decisions and thereby provide directions for future research.
JEL Classifications: C91; D03; H32; K34; M21; M41.
Dapagliflozin Impairs the Suppression of Endogenous Glucose Production in Type 2 Diabetes Following Oral Glucose
Authors: Alatrach Mariam , Agyin Christina , Solis-Herrera Carolina , Lavryneko Olga , Adams John , Gastaldelli Amalia , Triplitt Curtis , DeFronzo Ralph A. , Cersosimo Eugenio 
Published: March 2022

OBJECTIVE
To examine the effect of SGLT2 inhibitors (SGLT2i) on endogenous glucose production (EGP) in patients with type 2 diabetes after an oral glucose load.

RESEARCH DESIGN AND METHODS
Forty-eight patients with type 2 diabetes received an 8-h [3-3H]-glucose infusion (protocol I) to assess EGP response to: 1) dapagliflozin (DAPA), 10 mg; 2) exenatide (EXE), 5 μg s.c.; 3) DAPA/EXE; and 4) placebo (PCB). After 2 weeks (protocol II), patients were restudied with a 5-h double-tracer (i.v. [3-3H]-glucose and oral [1-14C]-glucose) oral glucose tolerance test (OGTT) preceded by PCB, DAPA, EXE, or DAPA/EXE.

RESULTS
Protocol I: EGP decreased (P &lt; 0.01) with PCB (2.16 ± 0.15 to 1.57 ± 0.08 mg/kg/min) and EXE (2.13 ± 0.16 to 1.58 ± 0.03) and remained unchanged (P = NS) with DAPA (2.04 ± 0.17 vs. 1.94 ± 0.18) and DAPA/EXE (2.13 ± 0.10 vs. 2.09 ± 0.03). During OGTT, EGP decreased (P &lt; 0.01) with PCB (2.30 ± 0.05 to. 1.45 ± 0.06 mg/kg/min) and EXE (2.53 ± 0.08 to 1.36 ± 0.06); with DAPA (2.20 ± 0.04 vs. 1.71 ± 0.07) and DAPA/EXE (2.48 ± 0.05 vs. 1.64 ± 0.07), the decrease in EGP was attenuated (both P &lt; 0.05). During OGTT, the insulin/glucagon (INS/GCN) ratio increased in PCB (0.26 ± 0.03 vs. 0.71 ± 0.06 μU/mL per pg/mL), whereas in DAPA (0.26 ± 0.02 to 0.50 ± 0.04), the increase was blunted (P &lt; 0.05). In EXE, INS/GCN increased significantly (0.32 ± 0.03 to 1.31 ± 0.08) and was attenuated in DAPA/EXE (0.32 ± 0.03 vs. 0.78 ± 0.08) (P &lt; 0.01).

CONCLUSIONS
These findings provide novel evidence that the increase in EGP induced by SGLT2i is present during an oral glucose load. The fact that stimulation of EGP occurs despite elevated plasma insulin and glucagon suggests that additional factors must be involved.
EFEKTIVITAS BAHAN AKTIF HERBISIDA DAN VARIETAS TERHADAP PENGENDALIAN GULMA, PERTUMBUHAN DAN HASIL TANAMAN BAWANG MERAH (Allium ascalonicum L.)
Authors: Deden Deden , Dukat Dukat , Nur Subandi 
Published: March 2022

Bawang merah saat ini sudah menjadi komoditas yang diperhitungkan di Indonesia, karena keberadaanya menjadi salah satu faktor variabel penentu inflasi secara ekonomi nasional. Kehadiran gulma diantara tanaman bawang merah menjadi kendala dan menyebabkan penurunan produktivitas hasil bawang merah, sehingga perlu dikendalikan secara tepat, efektif dan efisien. Selain itu, bibit merupakan salah satu faktor utama yang menentukan keberhasilan usaha tani bawang merah. Upaya dan strategi harus terus dikembangkan untuk dapat meningkatkan produksi bawang merah, khususnya upaya pengendalian gulma dan penggunaan varietas bibit yang tepat sehingga mampu meningkatkan produktivitas tanaman bawang merah. Tujuan penelitian adalah untuk mengetahui pengaruh bahan aktif herbisida dan varietas terhadap pengendalian gulma, pertumbuhan dan hasil bawang merah. Untuk mengetahui jenis bahan akif herbisida dan vaietas yang paling tepat untuk pengendalian gulma, pertumbuhan dan hasil bawang merah. Percobaan akan dilaksanakan di Desa Gagasari Kecamatan Gebang Kabupaten Cirebon.pada bulan Februari sampai dengan Mei 2021. Menggunakan Metode Rancangan Acak Kelompok (RAK) pola faktorial dengan 3 kali ulangan. Perlakuan terdiri dari dua faktor yakni faktor pertama adalah bahan aktif herbisida (H0 : Kontrol, H1 : Penyiangan petani, H2 : Oksifluorfen, H3 : Pendimetalin), sedangkan faktor kedua adalah 2 varietas bawang merah (V1 : Varietas Bima, V2 : Varietas Ilokos dan V3 : Varietas Sumenep). Pengamatan utama dilakukan terhadap fitotoksitas dan biomasa gulma, tinggi tanaman, jumlah daun dan bobot kering hasil bawang merah. Hasil penelitian menunjukan bahwa perlakuan herbisida (Oksifluorfen dan Pendimetalin) tidak menimbulkan fitotoksitas atau keracunan bagi tanaman utama bawang merah. Herbisida Oksifluorfen dan varietas sumenep secara mandiri memberikan perbedaan yang nyata terhadap tinggi tanaman pada pengamatan 21, 28 dan 35 HST. Herbisida Oksifluorfen, Pendimetalin dan penyiangan manual serta penggunaan varietas ilokos menunjukan perbedaan yang nyata terhadap jumlah daun. Pengendalian gulma pada tanaman bawang merah dengan menggunakan herbisida lebih efektif dilakukan bila dibandingkan dengan pengendalian penyiangan manual ataupun kontrol. Penggunaan herbisida Oksifluorfen mampu menghasilkan bobot umbi kering bawang merah 5,98 kg/petak atau setara dengan 12,57 ton/hektar. Jenis varietas ilokos mampu menghasilkan bobot umbi kering 5,85 kg per petak atau setara 12,16 ton/hektar.