bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correction of severe lower limb deformity with digital hexapod external fixator based on CT data
Authors: Lu Yufeng , Li Jinfeng , Qiao Feng , Xu Zhaochen , Zhang Baogang , Jia Bin , He Jinlong , Qi Liang , Wang Min , Fei Chen , Cao Xiaoming 
Published: November 2022

Abstract
Purpose: The current study aimed to investigate the therapeutic effect of our self-developed digital six-axis external fixator technique for correction of severe deformities of the lower extremities.
Patients and Methods: From January 2017 to December 2020, our institution used self-developed digital hexapod external fixator technology（QSF）based on CT data to slowly correct 28 severe tibial deformities, and 15 femurs underwent osteotomy and internal fixation. The mean age was 32.6±14.3 years, and the mean follow-up was 23.3±16.1 months. MAD, mFTA, MPTA, LLD, mLDFA at preoperative and final follow-up, and LEFS, KSS and functional score at preoperative and final follow-up were compared.
Results: The QSF adjustment time was 21.4±10.8 days, and the healing time of the tibial osteotomy site was 17.6±7.0 weeks. Preoperative MAD, mFTA, MPTA were 54.1±26.2 mm, 167.7±15.7°, 75.2±12.0°, respectively. At last follow-up, MAD was 8.2±9.9 mm, mFTA was 177.6±3.4°, and MPTA was 87.6±2.4°. Significant improvement was achieved after operation. Preoperative LLD, mLDFA were 13.8±18mm, 83.7±10.8°, at last follow-up were 7.6±7.6mm, 87.8±2.6mm, no significant difference before and after operation. The LEFS, KSS and functional scores improved from 51.6 ± 11.2, 68.5 ± 11.7, 67.8 ± 11.2 to 72.3 ± 6.1, 92.9 ± 3.4, 94.2 ± 6.3, respectively.
Conclusions: The QSF technique can accurately correct severe multiplanar deformities of the tibia in adults. Combined with femoral osteotomy to correct femoral deformity, satisfactory lower extremity alignment can be obtained. The technology has the advantages of simple operation, reliable fixation, less trauma and less complications.
Level of Evidence：Level IV, case series.
Pedological Data for the Study of Soils Developed Over a Limestone Bed in a Humid Tropical Environment
Authors: Ofem Kokei Ikpi , John Kingsley , Ediene Victoria Francis , Kefas Patrick Katan , Ede Alungbe Moses , Ezeaku Victor Ikemefuna , Pawlett Mark 
Published: November 2022

Abstract
Lithological characteristics interact with other factors of soil formation to define soil genesis. This becomes more interesting as data on the mineral and elemental oxide components of soils developed from limestone are rarely available in the humid tropical environment. The present study investigated the elemental oxide content, forms of sesquioxides, and clay mineral species in some limestone soils. Soil samples were obtained from three (3) crestal soil profile pits and analyzed for elemental content by the use of X-ray Fluorescence spectrometer, and sesquioxides forms by Inductively Coupled Plasma-Mass Spectrometer. Analyses were done in triplicates. The mineralogy of the clay fraction was determined on the A, B, C horizon samples using an X-ray diffraction Technique. The occurrence of SiO2 (203-277 g/kg), Al2O3 (65-105 g/kg), and Fe2O3 (14-95 g/kg) in substantial amounts over MnO2, ZrO2, and TiO2 with negligible quantities of CaO suggested comparatively more developed soils in the Agoi Ibami and Mfamosing tropical rainforests. Crystalline form of Fe was dominant over amorphous form, with indications of the co-migration of dithionite Fe with clay to the B horizons of the soils. Quartz, kaolinite, montmorillonite, and chlorite-vermiculite-montmorillonite interlayered minerals dominated the clay mineralogy of the studied soils. Mineral transformation places the soils at the transitory stage from the intermediate to the complete stage of soil development. The expanding clay minerals are most likely to increase plant nutrient adsorption and soil fertility status to accommodate the cultivation of a wider range of crops.
Beneficial effects of tannic acid on comorbid anxiety in cecal ligation and puncture-induced sepsis in rats and potential underlying mechanisms
Authors: Ranjbaran Mina , Kianian Farzaneh , Ashabi Ghorbangol , Lorian Keivan , Azizi Fateme 
Published: November 2022

Abstract
Sepsis-associated encephalopathy (SAE), a neurological dysfunction caused by sepsis, is the most common complication among septic ICU patients. Given the major role of inflammation in the pathophysiology of sepsis-induced anxiety, an extreme and early manifestation of SAE, the present study examined whether tannic acid, as an anti-inflammatory agent, has anxiolytic effects in cecal ligation and puncture (CLP)-induced sepsis. Forty male Wistar rats were assigned to four groups: 1) Sham; 2) Sham + Tannic acid; 3) Sepsis and 4) Sepsis + Tannic acid. Sepsis was induced by cecal ligation and puncture model. Animals in the Sham + Tannic acid and Sepsis + Tannic acid groups received tannic acid (20 mg/kg, i.p.), 6, 12 and 18 h after the sepsis induction. Twenty four hours after the sepsis induction, systolic blood pressure and sepsis score were assessed. Anxiety-related behaviors were evaluated using elevated plus-maze and dark-light transition tests. Moreover, inflammatory markers (TNF-α and IL-6), oxidative stress parameters (MDA and SOD) and protein levels (GABAA receptors and IL-1β) were measured in the brain tissue samples. Administration of tannic acid significantly improved sepsis score and hypotension which induced by sepsis. Anxiety-related behaviors showed a significant decrease in the Sepsis + Tannic acid group compared to the Sepsis group. Tannic acid caused a significant decrease in the brain inflammatory markers and a remarkable improvement in the brain oxidative status compared to the septic rats. Tannic acid prevented animals from decreasing GABAA receptors and increasing IL-1β protein levels in the brain tissue samples compared to the Sepsis group. This study indicated that tannic acid mitigated anxiety-related behaviors through decreasing inflammation and oxidative stress and positive modifying IL-1β/GABAA receptors pathway. Therefore, tannic acid shows promise as an efficacious treatment for comorbid anxiety in septic patients.
Specific clinical characteristics are correlated with long-term SARS CoV-2 IgG titers
Authors: Schnapp Aviad , Gutbir Yuval , Ohana-Sarna Lea , Ben-Nachum Noa , Benenson Talya , Gilad Rivka , Lazaroff Heiley , Zamir Chen Stein , Shimon Reif , Wolf Dana , Kerem Eitan 
Published: November 2022

Abstract
Purpose
To investigate the correlation between various clinical characteristics and long-term SARS CoV-2 IgG following a COVID-19 outbreak in a school.
Methods
532 sera of polymerase chain reaction (PCR)-tested children, adolescents and adults were collected seven months following a large eruption of COVID-19 in a high school in Jerusalem. Anti-S IgG antibody titers were obtained, quantified and analyzed in relation to clinical symptoms resulting from SARS CoV-2 infection.
Results
Only 80% of PCR-positive individuals at the time of the outbreak were seropositive seven months following exposure. IgG positivity was well-correlated with PCR-positivity, as was the IgG titer (ß=0.56, p < 0.01). Other correlations established included young age (ß=-0.12, p < 0.01) and symptoms including fever (ß=0.11, p = 0.02) and weakness (ß=0.14, p = 0.01). Households of individuals with negative serologies had fewer symptomatic members than households of IgG-positive individuals (p < 0.01).
Conclusions
Clinical symptoms of fever and weakness may serve as predictive factors for long-term SARS-CoV-2 IgG following exposure to the virus.
Effectiveness of a Drug Reminder Mobile Phone Application in Adhering to Uric Acid Lowering Therapy in Patients with Gout: An Open-Label, Randomized Controlled Trial
Authors: Phutthinart Nattharadee , Thaweeratthakul Phakhamon , Chanapai Wanwisa , Katchamart Wanruchada 
Published: November 2022

Abstract
Background: Most patients with chronic diseases have difficulties adhering to treatment,leading to unfavorable outcomes and anincreased healthcare burden. Our objective wasto evaluate the effectiveness of a drug reminder mobile phone application (app) in the adherence of patients to uric lowering therapy (ULT) in patients with gout with poor adherence.
Methods: We conducted an open-label,randomized controlled trial in 54 gout patients who had serum uric acid (SUA) greaterthan 6 mg/dL and poor adherence to ULT. The patients were randomly assigned to the reminder app "Drug diary" (N =25) or the patient education app "Roo-Rak-Koh" (N =29). The co-primary end points were the proportion of patients with high ULT adherence, based on the Medication Taking Behavior measure for Thai Patients (MTB-T) questionnaire, the percentage of adherence to the pill count, and the proportion of patients who achieved the SUA target (< 6 mg/dL). A stable dose of ULT was required throughout the study.
Results: At 12 weeks, the proportion of patients with high ULT adherence and the percentage of pill count were significantly higher in the drug reminder app group (63% vs 37%, p = 0.047 for MTB-T and 96% vs 93%, p=0.04, for pill count), while the SUA target was achieved in 48% and 47.8% in the drug reminder app group and in the patient education app group, respectively (p = 0.89). However, SUA reduction in SUA was significantly greater in the drug reminder app group (-1.63 ± 1.18 vs -0.76 ± 1.24, p = 0.01).
Conclusion:Mobile phone health applications can improve medical adherence in patients with chronic diseases requiring long-term medical treatment. In addition to drug reminder, optimal gout education also significantly improves gout care.
Trial registration: Thai Clinical Trial Registry (TCTR), TCTR20200123002. Registered 23 January 2020,http://www.thaiclinicaltrials.org/show/TCTR20200123002
Efficient adsorptive removal of diclofenac sodium by acidified MIL101(Cr): optimizing the content of phosphotungstic acid (PTA), Flow loop thin film slurry flat plate reactor, Kinetic, thermodynamic and recycling studies
Authors: Sharifian Sina , Tabrizi Farshad Farshchi , Sardarian Ali Reza 
Published: November 2022

AbstractThe performance of Diclofenac sodium (DFs) adsorption by MIL101(Cr) and five different contents of PTA in PTA@MIL101(Cr) (encapsulated phosphotungstic acid (PTA) using one pot method) were investigated in a batch and a designed continuous flow loop thin film slurry flat plate reactor (TFSR). Excellent diclofenac sodium adsorption efficiency was achieved with 12 wt% PTA synthesized within the Metal Organic Framework (MOF) and using the Langmuir equation the maximum adsorption capacity of diclofenac sodium was 413.22 mg/g. The Langmuir model matched the isotherm adsorption data and the removal process was complemented with a pseudo–second–order kinetics model. According to the thermodynamic analyses, the process was found to be spontaneous and endothermic. In order to regenerate the MOF, 0.1 M HCl/EtOH (20/80 v/v) best performed as elution agent, regenerating the MOF to 88% of its originated maximum capacity after 5 times reusing. PTA (12 wt%) @MIL101 (Cr) showed to be a tremendous reusable adsorbent for removing DFs from aqueous media.
Splines finite element solver for one-dimensional time-dependent Maxwell’s equations via Fourier Transform Discretization
Authors: Addam Mohamed , Bouhamidi Abderrahman , BARKANI Imad EL 
Published: November 2022

Abstract
In this article, we solve the time-dependent Maxwell coupled equations in their one-dimensional
version relatively to space-variable. We effectuate a variable reduction via Fourier transform to make
the time variable as a frequency parameter easy and quickly to manage. A Galerkin variational
method based on higher-order spline interpolations is used to approximate the solution relatively to
the spacial variable. So, the state of existence of the solution, its uniqueness, and its regularity are
studied and proved, and the study is also provided by an error estimate. Also, we use the critical
Nyquist frequency to calculate numerically the solution of the Inverse Fourier Transform(IFT); and
for all numerical computations, we consider several quadrature methods. We give some experiments
to illustrate the success of such an approach. Finally, we apply the higher-order spline interpolants
to solve the first kind of Fredholm integral equation and Pocklington’s integro-differential equation to
treat the signal reconstruction inside the wire antennas.
FeRM Model for Time Series Forecasting
Authors: Vijayakumar Vibinkumar , Domanic Gifty , Ummar Shaik , Afsal Muhammed 
Published: November 2022

Abstract
Time series forecasting is a way of analyzing the data points indexed in time order and fitting a model to predict future values. Time series data can be hourly, daily, weekly, monthly, or sometimes annual. Time series analysis is used to understand the underlying trends and patterns over time to accurately predict future outcomes. Traditional models such as ARIMA, and deep learning models such as RNNs, Transformers are used for long-term forecasting of time series because they effectively utilize historical information. However, there is still great room for improvement when it comes to the situation where historical data for training is limited. In this paper, we demonstrate a novel time series model with better predictions where the traditional models failed to exploit in view of the fact that not all time series problems can be solved by the traditional models. To this end, our model incorporates the sum of Fourier extrapolation, Rate of change approximation and arithmetic Mean of data points that elicit better predictions and reduced errors which importantly outweighed the state-of-the-art models with little computational overhead.
Scaling up Gas and Electric Cooking in Low- and Middle-Income Countries: Climate Threat or Mitigation Strategy with co-Benefits?
Authors: Floess Emily , Grieshop Andrew , Puzzolo Elisa , Pope Daniel , Leach Nicholas , Smith Christopher J. , Gill-Wiehl Annelise , Landesman Katherine , Bailis Rob 
Published: November 2022

Abstract
Nearly 3 billion people in low- and middle-income countries (LMICs) rely on polluting fuels, resulting in millions of avoidable deaths each year. Polluting fuels also emit short-lived climate forcers and greenhouse gases (GHGs). Liquefied petroleum gas (LPG) and grid-based electricity are scalable alternatives to polluting fuels but have raised climate and health concerns. Here, we compare emissions and climate impacts of a business-as usual household cooking fuel trajectory to four large-scale transitions to gas and/or grid electricity in 77 LMICs. We use upstream and end-use emissions in a reduced-complexity emissions-based climate model to estimate radiative forcing and temperature changes associated with each scenario. We find full transitions to LPG and/or electricity decrease emissions from both well-mixed GHG and short-lived climate forcers, resulting in a roughly 5 mK global temperature reduction by 2040. Transitions to LPG and/or electricity also reduce annual emissions of PM2.5 by over 6 Mt (99%) by 2040, which would substantial lower health risks.
Next generation pan-cancer blood proteome profiling using proximity extension assay
Authors: Uhlen Mathias , Álvez María Bueno , Edfors Fredrik , von Feilitzen Kalle , Zwahlen Martin , mardinoglu adil , Edqvist Per-Henrik , Sjöblom Tobias , Lundin Emma , Rameika Natallia , Axelsson Tomas , Åberg Mikael , Nordlund Jessica , Zhong Wen , Karlsson Max , Gyllensten Ulf , Pontén Fredrik , Fagerberg Linn 
Published: November 2022

Abstract
Cancer is a highly heterogeneous disease in need of accurate and non-invasive diagnostic tools. Here, we describe a novel strategy to explore the proteome signature by comprehensive analysis of protein levels using a pan-cancer approach of patients representing the major cancer types. Plasma profiles of 1,463 proteins from more than 1,400 cancer patients representing altogether 12 common cancer types were measured in minute amounts of blood plasma collected at the time of diagnosis and before treatment. AI-based disease prediction models allowed for the identification of a set of proteins associated with each of the analyzed cancers. By combining the results from all cancer types, a panel of proteins suitable for the identification of all individual cancer types was defined. The results are presented in a new open access Human Disease Blood Atlas. The implication for cancer precision medicine of next generation plasma profiling is discussed.
Effects of a dendritic cell vaccine loaded with whole tumor antigen in hu-PBL-SCID mice bladder cancer
Authors: Wang Bin , Song Jiwen , Chen Huiqing 
Published: November 2022

Abstract
Background: The effects of dendritic cell (DC) vaccine loaded with whole tumor antigen on bladder cancer model in human peripheral blood lymphocytes (hu-PBL) -severe combined immunodeficient (SCID) mice was ivestigated.
Methods: The peripheral blood mononuclear cells (PBMCs) were isolated from human peripheral blood, and were induced into DCs by co-culture with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4) in vitro. The DC vaccine were produced by co-culturing with whole tumor antigen which was purified through freezing and melting T24 cells. The animal model of tumor-bearing mice was established by SCID mice intraperitoneally injected with 4×107 hu-PBL and subcutaneously injected with 3×106 T24 cells. Animals were randomly allocated to an experimental group or control group. After T24 cells injected into SCID mice for 5 weeks, the mice were treated with DC vaccine or phosphate buffered saline (PBS). Human IgG level in the blood plasma of mice was detected by enzyme linked immunosorbent assay (EILSA), and human CD3+, CD4+, CD8+T cells in blood and spleen cells of mice were detected by flow cytometry (FCM) analysis. The tumor volume in each group were records. Matrix metalloproteinases-7 (MMP-7) mRNA expression in tumor tissue was detected by fluorescence quantitative reverse transcription polymerase chain reaction (FQ-RT-PCR).
Results and Conclusion: Tumor volumes and MMP-7 mRNA expression in tumor tissue of DC vaccine treated mice was statistically lower than PBS group (P<0.01). DC vaccine had an anti-tumor effect on hu-PBL-SCID mice bladder cancer model.
Phishing URL Detection Using CNN-LSTM and Random Forest Classifier
Authors: nepal sopnil , gurung hemant , nepal roshan 
Published: November 2022

Abstract
This paper presents the classification of phishing URL's apart from legitimate URL's with the use of machine learning and deep learning techniques. Phishing is defined as an act to steal the private information by pretending to be a legitimate entity which they are not. Machine learning model, Random Forest classifier is trained on the extracted features based on Address Bar, Domain and HTML and JavaScript of the URL. On the other hand, CNN-LSTM hybrid model was trained to learn the character sequence features of the given URL and make the classification. The dataset used was public data from Kaggle which was downloaded from their website. The dataset contained 11,430 URLs: 5,715 legitimate URLs and 5,715 phishing URL. Hereafter, we classified the URL of the current address bar as legitimate or phishing with the use of previously trained model. Thus, proposed paper focuses on the study and development of models for detection of phishing sites so that properties of various URLs can be learnt by feature extraction and can be classified as accurately as possible.
Pseudomembranous Colitis in a Coronavirus Disease 19 positive patient : not a simple issue.
Authors: Thayer Maissa Ben , Khanchel Fatma , Helal Imen , Zaafouri Haithem , Hedhli Raoueh , Brahim Ehsen Ben , Jouini Raja , Chadli-Debbiche Aschraf 
Published: November 2022

Abstract
Since its emergence, Coronavirus Disease (Covid-19) rapidly spread worldwide and was responsible for a global pandemic. Although it was initially considered a respiratory disease, recent studies have evidenced that Covid-19 had serious systemic adverse effects involving major organs, including those of the digestive system. Histological lesions associated with these manifestations have rarely been reported. We, herein, present a singular case of pseudomembranous colitis (PMC), proven histologically, in a 73-year-old Covid-19 positive female patient. We aim to study the clinico-pathological characteristics of this association. A 73-year-old Covid positive patient was intubated and put on intravenous antibiotherapy after the deterioration of her respiratory function. Ten days after admission, the patient presented abdominal distension and melena. An abdominal tomography scan showed a left mesenteric infarction related to a thrombosis at the origin of the left mesenteric artery. A left hemicolectomy was performed in emergency. Macroscopic examination of the hemicolectomy specimen showed an edematous colonic mucosa, with multiple ulcerations covered by a whitish necrotic coating reminiscent of false membranes. Histological examination confirmed the diagnosis of PMC. The patient presented a septic shock and died six days after the operation. The PMC could have resulted from the use of antibiotics. However, the direct involvement of Covid-19 in the occurrence of this PMC cannot be excluded. Further studies are needed to evaluate the direct correlation between Covid-19 and PMC.
Gunshot bullet trauma of the colon in combat patients injured in hybrid period of Russian-Ukrainian war during 2014-2020
Authors: Gumeniuk Kostiantyn , Lurin Igor A. , Tsema Ievgen , Malynovska Lesia , Gorobeiko Maksym , Dinets Andrii 
Published: November 2022

Abstract
Background
Gunshot wound to the colon is a frequent injury in armed conflicts. An example of high-energy modern weapon is hollow-point bullets, which is associated with an increased tissue damage and lethal outcome. The aim of this study was to evaluate gunshot injuries to the colon in combat patients and to investigate specific features of the hollow-point and shape-stable bullets features in colon injury.
Patients and methods
Analyses of clinical data was performed on 384 male soldiers from Armed Forces of Ukraine with gunshot abdominal wound with injury to the colon in East Ukraine between 2014 and 2020. Out of 374 injured, 112 (29.9%) patients were diagnosed with penetrating gunshot bullet wounds: 69/112 (61.6%) were injured by shape-stable bullets and 43/112 (38.4%) patients were injured by the hollow-point bullets.
Results
More severe hemorrhagic shock stages were in patients injured by hollow-point bullets: shock stages III-IV was in 25 (58.1%) patients injured by the hollow-point bullets vs. 17 (24.6%) patients injured by shape-stable bullets (p = 0.0004). Left colon parts were more frequently injured as compared to right colon side or transverse colon in 21 (48.8%) injured by shape-stable (p < 0.0001) and in 41 (59.4%) patients injured by the hollow-point bullets (p = 0.032). A significant difference was identified for the frequent injury to the middle colon within the entire cohort (p = 0.023). Patients injured with the hollow-point bullets demonstrated a higher frequency of 3–5 areas of colon penetration, which was detected in 18 (41.8%) patients injured by hollow-point bullets and none patients with shape-stable bullets injury (p = 0.0001). Colon Injury Scale (CIS) IV was detected in 9 (8%) patients injured by the hollow-point bullets as compared to 7 (10.1%) patients injured by shape-stable bullets (p = 0.031). Colostomy was performed in 9 (13%) patients injured by shape-stable bullets and in 8 (19%) patients injured by the hollow-point bullets (p > 0.05). 15 (35%) patients died after injury by the hollow-point bullet, whereas 9 (13%) patients after injury by the shape-stable bullets (p = 0.0089).
Conclusions
All patients should be suspected to have a hollow-point injury in case of penetrating injury (absent outlet wound) and careful revision of the abdomen must be performed to identify possible multiorgan injury as well as multiple perforations of the intestine.