bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monkeypox and cancer: a pan-cancer based multi-omics analysis and single cell sequencing analysis
Authors: Huang Xiaoliang , Long Xingqing , Liu Yanling , Chen Zuyuan , Xiang Xiaoyun , Mo Xianwei , Liu Jungang , Tang Weizhong 
Published: December 2022

Abstract
Background: Monkeypox is a zoonotic disease caused by monkeypox virus, and most infections cause systemic disease. Tumor patients are susceptible to various viruses, but there are few reports on the effects of genes related to monkeypox virus infection on the tumor microenvironment. Therefore, we need to further explore the expression of genes associated with monkeypox infection in tumor patients and the potential immune mechanisms in order to improve the survival and prognosis of tumor patients.
Methods: The gene expression, genetic variation, mRNA sequencing samples, clinical and methylation datas were from 33 cancer types of TCGG database. Single-cell transcriptome sequencing (scRNA-seq) was used to analyze the activation of monkeypox related genes in the tumor microenvironment. Then, Single sample gene set enrichment analysis (ssGSEA) and immunohistochemistry (IHC) were used in our research. The relationship between monkeypox and gene expression, clinical features, immune microenvironment, TMB and MSI was comprehensively evaluated.
Results: In this study, monkeypox-related genes were found to be closely associated with most tumorigenesis as well as drug sensitivity. Additionally, cellular enrichment pathways suggest that monkeypox is closely associated with invasion, cell cycle, DNA damage and repair. The prognostic value on monkeypox-related genes was evaluated, and it was found that monkeypox is a risk factor. Moreover,monkeypox-related genes are positively associated with immune cells as well as immune checkpoints in most tumors. Analysis of scRNA-seq indicates that monkeypox differs significantly among cells of the tumor microenvironment.
Conclusion: The current study explored the monkeypox-related genes in pan-cancer for the first time and provides new insights. We found that monkeypox-related genes are closely associated with the formation of immune microenvironments and immunotherapeutic efficacy of most tumor, which provides new ideas for the prevention and treatment of monkeypox and tumors.
Heronian Mean Operators Based on Complex Neutrosophic Uncertain Linguistic Sets and Their Application in Multi-Attribute Group Decision Making
Authors: Ali Zeeshan , Mahmood Tahir , Naeem Muhammad 
Published: December 2022

Abstract
The Heronian mean (HM) operator has the valuable characteristic of determining correlations among aggregated values. The HM operator is a massive feasible and more flexible technique to manage hurdle and awkward data in the circumstances of the fuzzy set (FS) theory. The major aims of this investigation are to analyze the novel theory of complex neutrosophic uncertain linguistic (CNUL) setting and their beneficial theories. The CNUL information includes uncertain linguistic sets, truth grade, abstinence grade, and falsity grade in the shape of complex numbers. In the occurrence of the novel concept of CNUL data, we try to invent the well-known theory of CNUL arithmetic HM (CNULAHM), CNUL weighted arithmetic HM (CNULWAHM), CNUL geometric HM (CNULGHM), CNUL weighted geometric HM (CNULWGHM) operators, which can help to aggregate the group of alternatives into a singleton element. Several attractive properties and their related results are also demonstrated. Additionally, to demonstrate the feasibility and rationality of the invented operators, multi-attribute group decision-making (MAGDM) performance is evaluated based on the invented works. Finally, we illustrated several examples to diagnose the sensitive analysis and graphically shown of the invented operators to express the consistency and feasibility of the evaluated works.
Relationship between silence behaviour, psychological empowerment, and patient safety culture among hospital staff: A multi-centre, cross-sectional study
Authors: Liu Hao , Zhang Hai-ying , Zhu Yong-kai , Huang Guo-ying , Xu Jia-hua 
Published: December 2022

Abstract
Background
As hospitals are under increasing pressure to improve quality and safety, safety culture has become a focal issue for high-risk organizations, including hospitals. Prior research has explored some of the factors that influence patient safety culture (PSC). However, there are relatively few related studies. In this study, we explored the relationship between silence behaviour, psychological empowerment, and PSC to find factors that affect the PSC in the hospital. Our study can serve as reference for hospital managers and for improving hospital service quality and patient safety.
Methods
The data for this study were from a multi-centre cross-sectional survey among hospital staff from six provinces/municipalities in China (N = 1034). Using correlation analysis and regression analysis to explore the impact of silence behaviour and psychological empowerment on PSC, we used a mediation model to explore the mediation effect among these three factors.
Results
Hospital staff PSC was correlated with silence behaviour and psychological empowerment. Furthermore, the effect of silence behaviour on PSC was mediated entirely through psychological empowerment. We found statistically significant differences in the perception of safety culture among respondents with different residential regions, sexes, education levels, and positions (P < 0.05).
Conclusions
Hospital managers should create an open and safe working atmosphere for hospital staff to for patient safety; improve the work system and mechanisms and open more communication channels to enhance the influence of employees. Reducing the punishment for mistakes, promoting a non-punitive safety culture through training, increasing the reporting frequency of adverse events, paying more attention to staffing, and paying attention to safety culture education of hospital administrative staff can effectively improve PSC and enhance patient safety.
UNINTENDED PREGNANCY AND ASSOCIATED FACTORS AMONG PREGNANT WOMEN LIVING WITH HIV BAHIRDAR TOWN PUBLIC HEALTH FACILITIES, NORTHWEST ETHIOPIA, 2022
Authors: Kefelegn Samuel , Aklilu Abayneh , Yetwale Fisseha , Amare Eyuel , Gashaw Anteneh 
Published: December 2022

Abstract
Background: Unintended pregnancy is a pregnancy that is untimely or unforeseen at the time of conception but may be wanted later.The burden and negative consequences of unintended pregnacy is miserable if it happens among HIV positive women.There was a paucity of evidence regarding unintended pregnancy among HIV positive women in the study area.
Objective:- To assess the prevalence and factor associated with unintended pregnancy among pregnant women living with HIV in Bahirdar town health care facilities 2022.
Methods:- An institution-based cross-sectional study was conducted from February 1st to march 30th 2022..A systematic sampling technique was employed to select 408 eligible women. A structured, pretested interview administered questionnaire and chart review was used to collect the data. Data were entered in to Epidata version 4.6 and exported to SPSS version 23 for data analysis. Multivariable logistic regression model fitted to identify factors associated with unintended pregnancy.Statical association was claimed based on the adjusted odds ratio (AOR) with its 95% CI and a p-value of ≤ 0.05.
Result :- Prevalence of unintended pregnancy among HIV positive pregnant women in Bahirdar town public health facilities was (22.4 %) with 95% CI=18.2- 26.4).Factors significantly associated with unintended pregnancy were, who doesn’t want more child [AOR:4.24,95%CI= 2.31-7.77], who don’t know about dual method [AOR:2.49,95%CI= 1.44-4.30] women taking ARV for more than five years [AOR:2.29,95%CI =1.32-3.95] and having non-regular sexual partner [AOR:0.30,95%CI=0.12-0.70) were significantly associated with unintended pregnancy.
Conclusion and recommendation:-Prevalence of unintended pregnancy among PWLHIV in Bahirdar town public health facilities was slightly less than the global unintended pregnancy prevalence. Better to give counselling on use of dual method and to practice safe sexual practice thereby decrease unintended pregnancy and reinfection with new virus.
Developing a Parenting Model for the Decent Use of Digital Media among the Teenagers in Bangladesh: A Qualitative Exploration
Authors: BakiBillah Abul Hasan , Khan Ayub , Muhammad Faisal , Chowdhury ABM Alauddin , Shahinuzzaman Md. , Hossain Syed Billal , Akram Muhammad , Almasri Nihad A. , Wani Mohammad Amin , Chowdhury Moniruddin , Ghosh Sanchita , Mukherjee Anindita , Kabir Russell 
Published: December 2022

Abstract
Background
In Bangladesh, parents are crucial in ensuring that teens use digital gadgets responsibly. The purpose of this study was to create a parenting paradigm within the context of the government's purges.
Method
Nineteen key informants took part in this study as part of the qualitative inquiry.
Results
Participants come from a variety of backgrounds and play a variety of roles that all support the same goal. The parenting model was created using the information from the interviews. By placing secondary and upper secondary educational institutions at the core of government action, parents will be educated. This approach was first proposed to be used in the "Generation Breakthrough" program of the Ministry of Education. Parents should be invited to the institutions to learn about the actions that need to be performed and followed under the two main categories, preventative and curative. Technology, the spoken word, psychology, and relationships built on evidence and trust are all examples of preventive approaches. Corrective measures include counseling, assistance with cyber security, legal services, and law enforcement.
Conclusion
In order to ensure that teens are using digital gadgets responsibly, this study suggests educating and empowering parents through a realistic strategy.
Molecular characterization and genetic diversity assessment in Mandukaparni (Centella asiatica L.) accessions
Authors: Singh Luwangshangbam James , Sane Anuradha , Thuppil Vasantha Kumar 
Published: December 2022

Abstract
Centella asiatica L. is an important herbaceous perennial medicinal plant commonly known as Mandukparni or Indian pennywort or Jalbrahmi or Gotu kola. It has been widely used in various traditional and modern medicine for its medicinal and nutritional properties. Although Centella asiatica L. is widely distributed throughout tropical and subtropical regions of India, only limited attempts have been made in exploiting diversity in conservation and crop improvement. Thus, the present study was aimed to assess the molecular diversity of its seventeen accessions by employing Simple Sequence Repeat markers. Among the twenty primers, eighteen primers showed seventy-five polymorphic bands which generated 97.40% polymorphism and two primers gave monomorphic bands across the accessions. The Polymorphism Information Content values ranged from 0.20 to 0.34 with an average of 0.26. The unweighted Pair Group Method with Arithmetic mean dendrogram grouped the accessions into two major clusters. The highest molecular distance shown at 56% in between the accessions (IIHR CA-5 and IIHR CA-16, IIHR CA-17) and (IIHR CA-8 and IIHR CA-17) revealed the most diverse pairs of accessions in comparison with other accessions. The results showed that Simple Sequence Repeat markers are suitable for assessing the genetic diversity of Centella asiatica accessions and the most diverse pairs of germplasms that is (IIHR CA-5 and IIHR CA 16, IIHR CA 17) and (IIHR CA-8 and IIHR CA 17) can be utilized in breeding programmes to widen the genetic base in this genetic crop improvement.
The clinical necessity of a distal forearm DEXA scan for predicting distal radius fracture in elderly females : a retrospective case-control study
Authors: Ma Sang Beom , Lee Sang Ki , An Young Sun , Kim Woo-suk , Choy Won Sik 
Published: December 2022

Abstract

Background:Recent studies have demonstrated that the distal forearm dual-energy X-ray absorptiometry (DEXA) scan might be a better method for screening bone mineral density (BMD) and the risk of distal forearm fracture, compared with a central DEXA scan. Therefore, the purpose of this study was to determine the effectiveness of a distal forearm DEXA scan for predicting the occurrence of distal radius fracture (DRF) in elderly females who were not initially diagnosed with osteoporosis after a central DEXA scan.Methods:Among the female patients who visited our institutes and who were over 50 years old and underwent DEXA scans at 3 sites (lumbar spine, proximal femur, and distal forearm), 228 patients with DRF (group 1) and 228 propensity score-matched patients without fractures (group 2) were included in this study. The patients’ general characteristics, BMD, and T-scores were compared. Odds ratios (OR) of each measurement and correlation ratio among BMD values of the different sites were evaluated.Results:The distal forearm T-score of the elderly females with DRF (group 1) was significantly lower than that of the control group (group 2) (p< 0.001 for the one third radius and ultradistal radius measurements). BMD measured during the distal forearm DEXA scan was a better predictor of DRF risk than BMD measured during the central DEXA (OR = 2.33;p= 0.031 for the one third radius, and OR = 3.98;p< 0.001 for the ultradistal radius). The distal one thirds radius BMD was correlated with hip BMD, rather than lumbar BMD (p< 0.05 in each group).Conclusion:Performing a distal forearm DEXA scan in addition to a central DEXA scan appears to be clinically significant for detecting the low BMD in the distal radius, which is associated with osteoporotic DRF in elderly females.Level of evidence:III; case-control study.
Multi-omics analysis to examine microbiota and metabolites in the colon of different breeds of swine
Authors: Zhu Yanbin , Sun Guangming , Cidan Yangji , Shi Bin , Tan Zhankun , Sun Fengbo , Ning Lihong , Han Haiyu , Wang Jinhui , Basang Wangdui 
Published: December 2022

AbstractBackground Host health and disease status are significantly influenced by the gut microbiome. However, the understandings of the gut microbiota in different breeds of pigs are largely unknown. Results In this study, six Duroc × landrace × yorkshire pigs and six Tibetan pigs were slaughtered to determine their short chain fatty acids (SCFAs) and microbes in colon and metabolites both in colon and plasma. The results revealed many variations between these two breeds of pigs. This study attempted to identify the major variables that explain the disparities in production performance between these two breeds of pigs. In our result, due to the significantly different relative abundances of microbes such asLachnospiraceae_NK4A136_group,AlloprevotellaandPrevotellaceae_UCG-003(P < 0.05), significantly higher concentrations of acetic acid, propionic acid and total SCFAs (P < 0.05), and significantly different concentrations of metabolites, duroc × landrace × yorkshire pigs showed better growth performance and health. Meanwhile, Tibetan pigs showed better abilities to use bile acid because of the higher relative abundances ofUCG-002andUCG-005, higher concentration of lithocholic acid and taurine, and higher expressions of bile acid receptors gene. Conclusion Based on the differences, the future studies could benefit these two breeds pigs’ production performance.
The effect of the vanillin-derived diene compound on the thermal, dielectric and mechanical properties of epoxy resins
Authors: yuan zhigang , Wang Lei , sun mingming , Zhang Xugang , Derradji Mehdi , zhang bin , Li Jianghui , Xue Gang , Zhao Ming , liu caizhao 
Published: December 2022

Abstract
In this work, a fluorine-containing diene compound (TFBAM) derived from vanillin was synthesized for modifying epoxy resin (E51). The chemical structure of TFBAM was confirmed by Fourier transform infrared (FTIR) and Nuclear magnetic resonance (1HNMR) spectroscopies. The modified resins (E-TFBAM) were successfully prepared through the introduction of TFBAM into E51, and the consequences of TFBAM dosages on the curing behavior, thermal, mechanical and dielectric properties of E-TFBAM resins were dissected in details. The results revealed that an appropriate concentration of TFBAM could be conductive to improving the thermal stability and dielectric properties of E-TFBAM thermosets without damaging the mechanical properties. The dielectric permittivity and loss of 2.82-2.71 and 0.024-0.015 were obtained when the addition of TFBAM was 30 wt%, with 10–10.2% and 36.8–44.4% of reduction. Additionally, the impact strengths and elongation at break of E-30 TFBAM resin increase to 18.0 kJ/m2 and 4.7%, respectively. Overall, this research can be seen as essential for expanding the application of the epoxy resins in high-end fields.
WITHDRAWN: A comprehensive Review of Innovative Human Resources Management
Authors: Atallah Ahmad 
Published: December 2022

Abstract

This study briefly reviews the research on novel approaches to HRM. Analysis of 47 articles yields three primary schools of thought when it comes to creative HRM. At its most basic, HRM innovation is just that. How human resource management handles novelty is the subject of other research. Thirdly, the term "innovative HRM" can be found in studies of inventiveness in business. Each of these three methods is discussed, along with their theoretical underpinnings. Implications for future study and practice are discussed at the end of the note.
WITHDRAWN: Upregulated HMGB3 resulting in the poor prognosis of lung adenocarcinoma by activating stromal angiogenesis through immune microenvironment
Authors: Feng Weirong , Bai Xiaoming 
Published: December 2022

Abstract
HMGB3 belongs to the high mobility group box (HMGB) family and the abnormally increased HMGB3 is associated with various types of malignancy progression. However, there is exiguous well clarified research to illustrate the correlation between HMGB3 and lung cancer. The expression profile data of lung adenocarcinoma (LUAD) were obtained from GEO and TCGA databases. The differential expression, prognostic survival, clinical characters, functional enrichment and immune infiltration were analyzed through R software, Kaplan–Meier (KM) plotter, ClusterProfiler package and ssGSEA algorithm. Besides, further research on HMGB3 expression level was confirmed using xenograft mice through immunohistochemistry and western blot assays. Results showed that HMGB3 was highly expressed in LUAD samples compared with adjacent normal samples. The T stage, pathologic stage, smoker and angiogenesis within the LUAD patients were positively correlated with HMGB3 expression. Functional enrichment analysis indicated that the correlative genes of HMGB3 are most related to the cell cycle process. HMGB3 is weakly related to the immune infiltration cells in LUAD stromal. However, increased existence of HMGB3 induced active angiogenesis in LUAD stromal and possibly accelerated the tumor progression through immune microenvironment. In conclusion, we confirmed that HMGB3 is a biomarker of poor prognosis for LUAD. The operative mechanism of which is activating tumor angiogenesis through immune infiltration cells. Further study will focus on exploring the related pathways in angiogenesis and immune microenvironment.
77GHz Down-Conversion Mixer with +18.4 dB High-Gain, +12.2 dBm OIP3, and Low-Noise in 90-nm CMOS Technology
Authors: Zhang Huan , Tang Sida , Cai Mengye , Jiang Yanfeng 
Published: December 2022

Abstract
In radio-frequency (RF) transceiver system, the receiver is used to convert RF signal to low/medium frequency for signal processing and information gathering. In the paper, a novel high-gain, low-noise CMOS mixer is designed and analyzed. In the design, gain-boosting and PMOS dynamic switching current are employed to achieve better effects of noise cancellation and trans-conductance enhancement. In order to improve the mixer's performance, the designed structure is mainly based on the double-balanced Gilbert lattice mixer combined with the parallel LC resonant and optimum biasing networks. The mixer shows high conversion gain (CG), low noise figure (NF), and low power consumption performances based on made possible by 90-nm CMOS technology. Operated at 77 GHz, the input third-order intercept point (IIP3) is -6.14 dBm, and the maximum conversion gain is 18.4 dB. At an IF frequency of 200 MHz, a bilateral band noise figure of 9.2 dB is recorded, while 6.96 mW is consumed with 1.2 V and 2 dBm LO power.
The use of a 30-degree radiolucent triangle during surgery in distal avulsion fractures of the patella
Authors: Ragot Léa , Gerber Filippo , Lannes Xavier , Moerenhout Kevin 
Published: December 2022

Abstract
Background
Avoiding patella baja or alta after the Krackow suture technique for distal avulsion fractures of the patella can be challenging. We aim to introduce a simple and reproducible technique using a 30-degree radiolucent triangle involving the contralateral knee to ensure the correct positioning of the patella intraoperatively.
Methods
The radiolucent triangle is positioned under the contralateral knee before operating the injured knee. A strict lateral view is obtained using fluoroscopy as a reference before a Krackow technique is performed on the avulsion fracture of the patella.
Results
The triangle technique is straightforward and easily reproducible by surgeons of all levels. It allows the surgeon to correctly position the patella intraoperatively in avulsion fracture repair and modify tension on the patellar tendon.
Conclusion
This method avoids millimetric mispositioning of the operated patella, thus improving the management intraoperatively and could decrease postoperative complications.
Experimental Study on Residual Deformation of Coal Gangue Filler under Multi-vibration Cyclic Loading
Authors: Xiaoyu Tang , Wen Wan , Zongtang Zhang , Wenhua Gao , Wang Yanhao 
Published: December 2022

Abstract
The use of coal gangue as roadbed filler can alleviate environmental problems and reduce environmental pollution. In this paper, the multi-vibration cyclic loading test of coal gangue roadbed filling body considering different confining pressure, compactness and gradation parameters is carried out. The deformation characteristics were studied, the residual deformation model was established, and the influence of different factors on the residual deformation value was discussed. The results show that under the cyclic loading of multiple vibration times, the deformation growth rate of coal gangue filler begins to increase, then slows down and tends to be constant. The actual residual deformation of coal gangue filler is not an accurate logarithmic relationship with the number of earthquakes. The shear and volumetric residual strains of 0 ~ 200 earthquakes have a quadratic function relation with logarithmic earthquake number lg (1 + N). There is a logarithmic relationship between the volume residual strain and the logarithmic number lg (1 + N) in 201 ~ 10000 earthquakes. All the influencing factors have a certain influence on the residual deformation value of the coal gangue specimen. According to the grey correlation degree calculation, the influence degree of the influencing factors of the coal gangue filler is ranked as the number of earthquakes, confining pressure, compaction degree and gradation. In addition, according to the grey correlation analysis, the influence of soil particle tumbling on the residual deformation is greater than the influence of soil particle crushing.