bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Scoliosis with One‐Stage Posterior Pedicle Screw System by Paraspinal Intermuscular Approach: A Minimum of Two Years of Follow‐Up
Authors: Song Qingxu , Leng Jiali , Qu Zhigang , Zhuang Xinming , Wang Yujian , Liu Yi , Wang Zhenyu 
Published: September 2022

AbstractObjectiveTo evaluate the clinical efficacy of the treatment of scoliosis with a pedicle screw system through paraspinal intermuscular approach (PIA).MethodsThis is a retrospective case series study. A total of 10 patients diagnosed with scoliosis had surgical indications and treated with a pedicle screw system in one‐stage posterior surgery by PIA from March 2013 to April 2015 at the First Hospital of Jilin University were enrolled in this study. The average age of the patients was 14.9 years, including one male and nine females. The operative information and surgical results, including Cobb angle correction, correction loss, global balance (including Frontal Plane Balance [FPB] and Sagittal Plane Balance [SPB]), and fusion rate were reviewed. Functional outcomes including visual analog scale (VAS) back pain score, leg pain score, and Scoliosis Research Society‐22 questionnaire (SRS‐22) were used to evaluate the quality of life of patients preoperatively and at last follow‐up.ResultsEach patient was followed up at least six times. The average follow‐up time was 43.2 months. Mean scoliosis and kyphosis improved from 68.5° ± 18.1°to 18.7° ± 11.8° and from 34.4° ± 17.9°to 24.0° ± 6.7°, respectively (p < 0.05); at last follow‐up, it was 20.1° and 24.7°, respectively (p > 0.05). During the follow‐up, mean coronal and sagittal correction loss was 1.4° ± 1.2°and 0.7° ± 0.8°, respectively (p > 0.05). Mean FPB improved from 32.7 to 11.7 mm (p < 0.05); Mean SPB changed from 0.3 to −0.7 mm (p > 0.05). No dural tears were observed during the corrective surgery or wound infection or implant‐related complications. No pseudoarthrosis was identified according to the last follow‐up three‐dimensional (3D) CT scan. All the domains in SRS‐22 questionnaire show statistically significant improvement at the last follow‐up (p < 0.05). The VAS back pain scores improved from a mean preoperative score of 1.7 to a mean postoperative score of 0.2 (p < 0.05).ConclusionThis original one‐stage posterior PIA is safe and effective in the treatment of scoliosis, which is characterized with less blood loss, shorter operation time, and satisfactory bony fusion.
In VitroEffect of 445 nm Blue Laser and 660 nmLow‐LevelLaser on the Quantity and Quality of Human Gingival Fibroblasts
Authors: Motlagh Kimia Hafezi , Azizi Arash , Ghadim Nahid Moezzi 
Published: September 2022

AbstractLow‐level laser therapy (LLLT) has several benefits in dentistry, including anti‐inflammatory effects and increased proliferation. This study aimed to investigate the effect of 445 nm blue laser and 660 nm low‐power laser on the quantity and quality of human gingival fibroblastsin vitro. In thisin vitroexperimental study, 445 nm and 660 nm lasers were irradiated on the samples six times. After examining the cells on the 7thand 14thdays, the data were analyzed using ANOVA PASS11 and thepost hocTukey test. The results showed the positive effect of the 660 nm laser on fibroblast proliferation. The viability on the 7thday was the highest in the control group, lowest in the 445 nm laser group and highest in the 660 nm laser group on the 14thday. In the morphological examination, the cells were spherical with narrow appendages in the control group, spindle‐shaped with lamellipodia appendages in the 660 nm laser group and spherical with no cytoplasmic appendages in the 445 nm laser group. Evidence of necrosis and granulation phenomenon was observed in the 445 nm laser group. The use of the 660 nm low‐power laser, compared with the 445 nm laser, has a positive effect on the quantity and quality of gingival fibroblasts.
Seasonal and inter‐annual variability in the heatwave tolerance of the kelpSaccharina latissima(Laminariales, Phaeophyceae)
Authors: Niedzwiedz Sarina , Diehl Nora , Fischer Philipp , Bischof Kai 
Published: September 2022

SummaryThe geographical distribution of organisms, such as the foundation kelp speciesSaccharina latissima, is mainly driven by temperature. Globally increasing sea surface temperature and further intensification of marine heatwaves have already resulted in local extinction of kelp populations worldwide. In the present study, we investigated temporal variation in the thermal susceptibility ofS. latissimaby assessing stress responses of field sporophytes sampled from Helgoland (German Bight) in June 2018, August 2018 and August 2019 in heatwave scenarios. We analyzed survival, growth, maximum quantum yield of photosystem II (Fv/Fm) and pigment composition. Survival decreased with increasing environmental and experimental temperatures. Growth revealed seasonal patterns, being higher in June than in August, whereasFv/Fmdecreased with increasing temperature, independent of the sampling time. We found an increase in the concentration of light harvesting pigments and in the de‐epoxidation state of the xanthophyll cycle with higher treatment temperature. This pattern was even more pronounced at higher environmental temperature prior to the experiment (June 2018 < August 2019 < August 2018). Our results show that the thermal tolerance ofS. latissimatowards heatwaves in summer is significantly affected by the environmental history it previously experienced.
Cost‐effectiveness of media reporting guidelines for the prevention of suicide
Authors: Flego Anna , Reifels Lennart , Mihalopoulos Cathrine , Bandara Piumee , Page Andrew , Fox Tina , Skehan Jaelea , Hill Nicole T. M. , Krysinska Karolina , Andriessen Karl , Schlichthorst Marisa , Pirkis Jane , Le Long Khanh‐Dao 
Published: September 2022

AbstractIntroductionMedia guidelines for the responsible reporting of suicide are a recognized universal suicide prevention intervention. While implemented in numerous countries, including Australia, little is known about whether they are cost‐effective. We aimed to determine the cost‐effectiveness of Mindframe, the national initiative implementing media guidelines in Australia.MethodWe conducted a modelled economic evaluation (5‐year time‐horizon) incorporating two types of economic analysis: (i) return‐on‐investment (ROI) comparing estimated cost savings from the intervention to the total intervention cost, and (ii) cost‐effectiveness analysis comparing the net intervention costs to health outcomes: suicide deaths prevented and quality‐adjusted life‐years (QALYs). We also included uncertainty analyses to propagate parameter uncertainty and sensitivity analyses to test the robustness of the model outputs to changes in input parameters and assumptions.ResultsThe estimated ROI ratio for the main analysis was 94:1 (95% uncertainty interval [UI]: 37 to 170). The intervention was associated with cost savings of A$596M (95% UI: A$228M to A$1,081M), 139 (95% UI: 55 to 252) suicides prevented and 107 (95% UI: 42 to 192) QALYs gained. The intervention was dominant, or cost‐saving, compared with no intervention with results being robust to sensitivity analysis but varying based on the conservativeness of the parameters entered.ConclusionMindframe was found to be cost‐saving, and therefore, worthy of investment and inclusion as part of national suicide prevention strategies.
Emergence of Exceptional Points in Periodic Metastructures With Hidden Parity-Time Symmetric Defects
Authors: Fang Yanghao , Kottos Tsampikos , Thevamaran Ramathasan 
Published: September 2022

Abstract
We study the elastodynamics of a periodic metastructure incorporating a defect pair that enforces a parity-time (PT) symmetry due to judiciously engineered imaginary impedance elements—one having energy amplification (gain) and the other having an equivalent attenuation (loss) mechanism. We show that their presence affects the initial band structure of the periodic Hermitian metastructure and leads to the formation of numerous exceptional points (EPs) which are mainly located at the band edges where the local density of modes is higher. The spatial location of the PT-symmetric defect serves as an additional control over the number of emerging EPs in the corresponding spectra as well as the critical non-Hermitian (gain/loss) strength required to create the first EP—a specific defect location minimizes the critical non-Hermitian strength. We use both finite element and coupled-mode-theory-based models to investigate these metastructures and use a time-independent second-order perturbation theory to further demonstrate the influence of the size of the metastructure and the PT-symmetric defect location on the minimum non-Hermitian strength required to create the first EP in a band. Our findings motivate feasible designs for the experimental realization of EPs in elastodynamic metastructures.
Informed Sampling-Based Planning to Enable Legged Robots to Safely Negotiate Permeable Obstacles
Authors: Chen Yiyu , Lian Lingchen , Hsieh Yu-Hsiu , Nguyen Quan , Gupta Satyandra K. 
Published: September 2022

Abstract
Legged robots have a unique capability of traversing rough terrains and negotiating cluttered environments. Recent control development of legged robots has enabled robust locomotion on rough terrains. However, such approaches mainly focus on maintaining balance for the robot body. In this work, we are interested in leveraging the whole body of the robot to pass through a permeable obstacle (e.g., a small confined opening) with height, width, and terrain constraints. This paper presents a planning framework for legged robots manipulating their body and legs to perform collision-free locomotion through a permeable obstacle. The planner incorporates quadrupedal gait constraint, biasing scheme, and safety margin for the simultaneous body and foothold motion planning. We perform informed sampling for the body poses and swing foot position based on the gait constraint while ensuring stability and collision avoidance. The footholds are planned based on the terrain and the contact constraint. We also integrate the planner with robot control to execute the planned trajectory successfully. We validated our approach in high-fidelity simulation and hardware experiments on the Unitree A1 robot navigating through different representative permeable obstacles.
A Comparison of Sodium Citrate and Sodium Bicarbonate Ingestion: Blood Alkalosis and Gastrointestinal Symptoms
Authors: Urwin Charles S. , Snow Rodney J. , Condo Dominique , Snipe Rhiannon M.J. , Wadley Glenn D. , Convit Lilia , Carr Amelia J. 
Published: September 2022

This study compared the recommended dose of sodium citrate (SC, 500 mg/kg body mass) and sodium bicarbonate (SB, 300 mg/kg body mass) for blood alkalosis (blood [HCO3−]) and gastrointestinal symptoms (GIS; number and severity). Sixteen healthy individuals ingested the supplements in a randomized, crossover design. Gelatin capsules were ingested over 15 min alongside a carbohydrate-rich meal, after which participants remained seated for forearm venous blood sample collection and completion of GIS questionnaires every 30 min for 300 min. Time-course and session value (i.e., peak and time to peak) comparisons of SC and SB supplementation were performed using linear mixed models. Peak blood [HCO3−] was similar for SC (mean 34.2, 95% confidence intervals [33.4, 35.0] mmol/L) and SB (mean 33.6, 95% confidence intervals [32.8, 34.5] mmol/L, p = .308), as was delta blood [HCO3−] (SC = 7.9 mmol/L; SB = 7.3 mmol/L, p = .478). Blood [HCO3−] was ≥6 mmol/L above baseline from 180 to 240 min postingestion for SC, significantly later than for SB (120–180 min; p < .001). GIS were mostly minor, and peaked 80–90 min postingestion for SC, and 35–50 min postingestion for SB. There were no significant differences for the number or severity of GIS reported (p > .05 for all parameters). In summary, the recommended doses of SC and SB induce similar blood alkalosis and GIS, but with a different time course.
Linking the Pinware, Baraboo, and Picuris orogens: Recognition of a trans-Laurentian ca. 1520–1340 Ma orogenic belt
Authors: Daniel Christopher G. , Indares Aphrodite , Medaris Jr. L. Gordon , Aronoff Ruth , Malone David , Schwartz Joshua 
Published: September 2022

ABSTRACT
It is proposed that the Pinware orogen of eastern Canada, the Baraboo orogen of the midcontinent, and the Picuris orogen of the southwestern United States delineate a previously unrecognized, ~5000-km-long, ca. 1520–1340 Ma trans-Laurentian orogenic belt. All three orogenic provinces are characterized by Mesoproterozoic sedimentation, magmatism, metamorphism, and deformation—the hallmarks of a tectonically active plate margin. Tectonism was diachronous, with the earliest stages beginning ca. 1520 Ma in eastern Canada and ca. 1500 Ma in the southwest United States. Magmatic zircon age distributions are dominated by Mesoproterozoic, unimodal to multimodal age peaks between ca. 1500 and 1340 Ma. The onset of magmatism in the Pinware and Baraboo orogens was ca. 1520 Ma, and onset for the Picuris orogen was ca. 1485 Ma. Detrital zircon age distributions within each orogenic province yield maximum depositional ages between ca. 1570 and 1450 Ma. Minimum depositional ages generally fall between ca. 1500 and 1435 Ma, as constrained by crosscutting intrusions, metatuff layers, or the age of subsequent metamorphism. Metamorphic mineral growth ages from zircon, garnet, and monazite yield peak ages between ca. 1500 and 1350 Ma and tend to be older in the Pinware and Baraboo orogens than in the Picuris orogen. The 40Ar/39Ar cooling ages for hornblende, muscovite, and biotite yield significant peak ages between ca. 1500 and 1350 Ma in the Baraboo and Picuris orogens. We propose that the Pinware-Baraboo-Picuris orogen formed in a complex, diachronous, convergent margin setting along the southern edge of Laurentia from ca. 1520 to 1340 Ma.
Comparative effect of metformin versus sulfonylureas with dementia and Parkinson’s disease risk in US patients over 50 with type 2 diabetes mellitus
Authors: Newby Danielle , Linden Andrew Brent , Fernandes Marco , Molero Yasmina , Winchester Laura , Sproviero William , Ghose Upamanyu , Li Qingqin S , Launer Lenore J , Duijn Cornelia M van , Nevado-Holgado Alejo J 
Published: September 2022

IntroductionType 2 diabetes is a risk factor for dementia and Parkinson’s disease (PD). Drug treatments for diabetes, such as metformin, could be used as novel treatments for these neurological conditions. Using electronic health records from the USA (OPTUM EHR) we aimed to assess the association of metformin with all-cause dementia, dementia subtypes and PD compared with sulfonylureas.Research design and methodsA new user comparator study design was conducted in patients ≥50 years old with diabetes who were new users of metformin or sulfonylureas between 2006 and 2018. Primary outcomes were all-cause dementia and PD. Secondary outcomes were Alzheimer’s disease (AD), vascular dementia (VD) and mild cognitive impairment (MCI). Cox proportional hazards models with inverse probability of treatment weighting (IPTW) were used to estimate the HRs. Subanalyses included stratification by age, race, renal function, and glycemic control.ResultsWe identified 96 140 and 16 451 new users of metformin and sulfonylureas, respectively. Mean age was 66.4±8.2 years (48% male, 83% Caucasian). Over the 5-year follow-up, 3207 patients developed all-cause dementia (2256 (2.3%) metformin, 951 (5.8%) sulfonylurea users) and 760 patients developed PD (625 (0.7%) metformin, 135 (0.8%) sulfonylurea users). After IPTW, HRs for all-cause dementia and PD were 0.80 (95% CI 0.73 to 0.88) and 1.00 (95% CI 0.79 to 1.28). HRs for AD, VD and MCI were 0.81 (0.70–0.94), 0.79 (0.63–1.00) and 0.91 (0.79–1.04). Stronger associations were observed in patients who were younger (<75 years old), Caucasian, and with moderate renal function.ConclusionsMetformin users compared with sulfonylurea users were associated with a lower risk of all-cause dementia, AD and VD but not with PD or MCI. Age and renal function modified risk reduction. Our findings support the hypothesis that metformin provides more neuroprotection for dementia than sulfonylureas but not for PD, but further work is required to assess causality.
The challenge of ensuring elderly people can access their health insurance entitlements: a mixed methods study on the Republic of Srpska’s Protector of Patients’ Health Insurance Entitlements
Authors: Stojisavljević Stela , Đikanović Bosiljka , Vončina Luka , Scott Kerry , Shroff Zubin , Manigoda Dijana , Štrbac Savka , Bosančić Borut , Mathauer Inke 
Published: September 2022

IntroductionHealthcare utilisation requires knowing one’s entitlements and how to access them (navigation) and having access to grievance redressal when entitlements are denied. To ensure citizen access to and use of health insurance entitlements, the Health Insurance Fund established an initiative called the Protector of Patients’ Health Insurance Entitlements (PPHIE). PPHIEs are supposed to provide patient navigation and grievance redressal services. This paper explores to what extent this initiative meets its objectives and is used by the elderly in rural areas.MethodsThis study employed a mixed methods approach. We conducted in-depth interviews with elderly patients in rural areas, PPHIEs, health providers and health insurance managers (N=39), as well as focus groups (N=5) and a household survey (N=715) with elderly rural patients. Qualitative data were analysed using content analysis, and the household survey results were analysed using descriptive statistics.ResultsThe majority of elderly patients were not aware of the PPHIE initiative and instead received patient navigation support from their healthcare providers. The PPHIE programme was poorly publicised among the population. Although PPHIEs had a mandate to pursue grievance redressal they rarely did so, and their role in the system was more symbolic than functional.ConclusionWhile healthcare providers have (by default) filled the navigation role left by inactive PPHIEs, the grievance redressal role remains unfilled. Information about health insurance entitlements and access to grievance redressal must be provided through visible, accessible and efficient mechanisms that should be continuously monitored and improved.
Cleaning up plastics in healthcare waste: the transformative potential of leadership
Authors: Rasheed Fawzia N , Walraven Gijs 
Published: September 2022

This article argues that plastics ought to be included under the category of ‘hazardous’ healthcare waste and suggests that health professionals should strive for alternatives as part of their mission to improve health. The focus of this paper is on replacing, rather than recycling, plastics. The rationale for this stance stems from the unbridled escalation of plastics use, the fact that few countries have significant recycling capacity, and because the process of recycling as well as the end products of recycled plastics remain hazardous to health and the environment.Issues related to incinerated plastic, plastics in single-use items, plastic blister packs and containers for medicines, as well as plastics which are unrelated to healthcare but which nevertheless make up a substantial part of general healthcare waste are discussed. Suggestions are put forward to dramatically reduce plastics in all such cases.To support needed reforms and to guide best practice for single-use plastics in particular, a call for a reliable reference source is made—similar to the Essential Medicines Lists, which would share updated information on the most problematic items in use and environmentally friendly alternatives in each case.It is argued that concerted action by health professionals to improve healthcare waste, beginning with plastics, would send much needed market signals to industry to produce environmentally-friendly products for healthcare and would likely lead to solutions for domestic waste, too.
Hodges’ model: the Sustainable Development Goals and public health – universal health coverage demands a universal framework
Authors: Jones Peter , Wirnitzer Katharina 
Published: September 2022

Background to issueFuture sustainable healthcare delivery and systems need reflective practitioners and critical thinkers to engage the public to achieve health policy aims and objectives. Therefore, this descriptive review introduces a generic conceptual framework, adopting a specific theme to illustrate and demonstrate a model of care or any other context. Whatever the purpose, context or philosophical stance in healthcare and health literacy, there is no standardised generic conceptual framework to structure reflection and critical thinking. This work presents a pragmatic solution focused on the one-to-one relationship of learner–mentor, patient–clinician, public health professional–public and groups.MethodsThe method is constructivist, an educational exercise, practical and the target group can be defined/viewed as student, teacher, patient, carer or member of the public in a health promotion campaign, for example. The building blocks are health and care concepts that arise clinically in practice, or for a student writing an assignment. As will be explained, concepts (including the Sustainable Development Goals) are assigned by the subject(s)—in this instance the authors—to a domain of knowledge.ResultsAs two-by-two tables, the results represent the structure of the conceptual framework, framing the content in a series of four knowledge (care) domains. The contents, ultimately the Sustainable Development Goals, may then be linked and relationships discussed. Results are produced gradually, building a cognitive or mind-map. The results, it must be stressed, are therefore qualitative.ConclusionDrawing on educational theory and practice, the results are explored and justified using the theme of nutrition, and the often stated desirability in education of reflective practice and critical thinking abilities. Providing a series of cross-disciplinary, the reader will gain insight into the potential of Hodges’ model to facilitate integrated, person-centred and care that improves parity of esteem, supporting students and qualified personnel in their learning careers.