bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE IMPORTANCE OF PUBLIC ADMINISTRATION IN ADMINISTRATIVE AND LEGAL REGULATION
Authors: Berezhna Kateryna , Yuzikova Nataliia , Maistro Serhii , Paliukh Viktor , Antonova Liudmyla 
Published: February 2022

The article examines a place, influence and significance of the category of «public administration» in the context of studying of juridical disciplines of administrative and legal cycle. It determines a number of prerequisites for clarifying a legal nature, in particular, a subject of the legal regulation of administrative law and administrative procedure through the influence of the category «public administration». The first section includes the procedural changes in the framework of system update of regulatory and legal base, first of all legislative one, in relation to the functional introduction of new institutes of administrative and legal cycle (the institutes of «administrative justice», «administrative services») and implementation of the results of performed administrative reform. The second section of preconditions includes theoretical and category changes in relation to the update of conceptual framework that are a logical result of the fundamental scientific achievements of the leading research-methodological legal administrative schools. The author’s definitions for «public administration» and «public management» are formulated as well as their correlation under the principle «from the general to the special» where public administration is the general concept and public administration is the special one. It is established that the category «public interest» is a system and forming component and actually, the basic one in interpreting «public administration». On the one hand, it is considered as a quintessence for the continuous implementation of public international and constitutional rights, such as: the right to form a governance (electoral law), to public service, to social security, and on the other hand as the activities of public bodies in the area of observance of the principles of legality, the rule of law, publicity, inevitability of punishment. The range of problems under consideration is evaluated in the articles published in the professional periodicals of Ukraine, in the papers of international and All- Ukrainian conferences as well as in academic programs of disciplines «administrative law», «administrativeprocedure».
CULTURAL DIALOG AS A MULTI-COMPONENT MEANS OF FORMING A TOLERANT PERSONALITY
Authors: S. Hajrullina Alfira , F. Dautov Gumar , R. Mugtasimova Gulnaz , A. Mukimova Nasima 
Published: February 2022

This paper considers the possibilities of cultural dialog in the formation and education of a tolerant personality. Modern educational paradigms are studies in terms of humanization and humanitarization of education; creative use of tolerance; issues of formation of moral values based on meaningful value bases of human life and society; value attitude to a person; search for the meaning of life through the characters on the example of the works of Razil Valeev. The analysis of scientific literature allows identifying a number of its features: the upbringing of a person as a subject of action; finding a dominant inside the life itself; the formation of a tolerant personality in the context of a cultural dialog, and others. The authors analyze the prose of the famous Tatar writer Razil Valeev. The research complements the theoretical space of the actual pedagogical problem, makes it possible to consider the research in a practical aspect. This is because the proposed model can be used by teachers, school teachers at lessons of national pedagogy, native literature and extracurricular activities for educational work
DESAFIOS DO PROFESSOR NA PANDEMIA
Authors: Santana de Souza Tiago 
Published: February 2022

Sabemos que há quase dois anos enfrentamos um momento bastante delicado que tem afetado o mundo inteiro e diversas áreas do nosso cotidiano. Dentre elas tivemos paralisação da Industria, cultura, comercio e outras áreas extremamente importantes para nós como a educação por exemplo. Desta forma a educação teve de passar por inovações para que não permanecesse paralisada. O estudo em questão buscar expor alguns desafios que a pandemia trouxe para o professor, sendo assim tivemos como temática central para este estudo Desafios Do Professor Na Pandemia. Como aporte metodológico para a construção da presente pesquisa utilizamos a pesquisa bibliográfica onde desfrutamos de matérias já publicados por autores com temática relacionadas ao nosso estudo. Dentre os principais autores tivemos Andrade, Barbosa, Cardoso, Arruda, Silva e outros que contribuíram para a produção da pesquisa em questão. Por fim, através dos dados colhidos e analisados, foi notório que o professor teve de enfrentar e superar vários desafios que vão desde a falta de recursos, adaptação de um novo formato de ensino que exigia que professor tivesse grandes habilidades com as tecnologias, e outros como a jornada de trabalho estendida, cansaço mental e fragilidades emocionais.
Factors associated with mortality in younger and older (≥75 years) hospitalized patients with community-acquired pneumonia
Authors: Aydin Mehtap , Şaylan Bengü , Ekiz İşcanlı İnşa Gül 
Published: February 2022

BACKGROUND:
Pneumonia is among the most serious infections in the elderly. The evaluation of prognosis and predicting the outcome is essential in managing the treatment of patients with pneumonia.

OBJECTIVE:
Evaluate factors that might affect the mortality of elderly patients hospitalized for community-acquired pneumonia (CAP) in two age groups.

DESIGN:
Medical record review.

SETTINGS:
Tertiary care hospital.

PATIENTS AND METHODS:
The study included CAP patients who were hospitalized during the period from January 2017 and December 2019. The CURB-65 scale was chosen to assess the severity of pneumonia on admission. Multivariate analyses were conducted separately for patients younger than 75 years and 75 years or older.

MAIN OUTCOME MEASURES:
30-day mortality, factors associated with mortality.

SAMPLE SIZE AND CHARACTERISTICS:
1603 patients with a median age of 74, including 918 women (57%).

RESULTS:

The 30-day mortality rate was 6.5%. Patients with carbapenem-resistant gram-negative bacteria had lower survival rates (
P
<.0001). In the multivariate analysis, age, lung cancer, CURB-65, carbapenem resistance, and duration of hospital stay were associated with mortality in patients aged 75 years or older. Lung cancer, malignant disease, carbapenem resistance, duration of hospital stay and procalcitonin level were associated with mortality under the age of 75. Of 640 sputum cultures tested,
P aeruginosa
(42%) was the most common pathogen.

CONCLUSION:
The risk factors that affected mortality differed among patients aged 75 years or older versus younger patients. Our findings are important in determining factors associated with mortality in managing the treatment and follow up of hospitalized CAP patients younger or 75 years of age or older.

LIMITATIONS:
Single-center, retrospective.

CONFLICT OF INTEREST:
None.
Efektivitas Inovasi Pengelolaan Sungai dan Penataan Sanitasi Sebagai Konsep Suistainable Development Dalam Penanganan Masalah Perkotaan di Probolinggo
Authors: Astutik Murtias Puji , Aisyah Rizaa , Maulina Renanda , Rachman Dinda , Hasanah Zairotul 
Published: February 2022

Sanitation and river management have become issues that have not been resolved lately because considering the growth and development of such population in the City or Regency is a problem that sounds very complete. This sanitation program is motivated to avoid a disease that causes death. So, the implementation of clean living is more encouraged considering that the City of Probolinggo is prone to flooding. This research will explain how a program to make river sanitation and management in the City of Probolinggo become more focused and orderly by implementing development and participation in the local community or residents. By using qualitative research methods and the descriptive approach used is the unit of analysis in the form of the concept of community-based development to determine the local socio-cultural conditions by paying attention to the values in the community.
Keywords: River Management, Sustainable Development, Sanitation
Pituitary deficiency after brain radiation therapy in childhood
Authors: Rbiai Najoua , Latrech Hanane 
Published: February 2022

Introduction: As part of an anticancer therapy, craniospinal radiotherapy causes variable degrees of hormonal deficiencies. The onset of hormonal deficiencies depends on the dose delivered to the pituitary –hypothalamic region while their incidence and severity depends on dose fractionating and follow up duration.
Objectives: Analyzing the long –term endocrine complications in children treated with craniospinal radiotherapy.
Material and methods: A prospective study; including 4 medical files collected over a period of 2 years.
Results: The study includes 4 patients with a sex ratio of 3M/1F; and a mean age of 18, 62 years. The average age at the time of irradiation was 9, 12 years. The delay between the end of radiotherapy and the first consultation varied between 1 year and 21 years. The radiotherapy was administred for medulloblastoma (n=1), Burkitt lymphoma (n=1), cavum cancer (n=1), Posterior Cranial Fossa Tumor (n=1).
The hormonal assessment revealed: a central hypothyroidism in 3 patients, corticotropin insufficiency in 2 cases, and gonadotropin deficiency associated with micropenis in one case. No cases of diabetes insipidus have been reported. Pituitary hypothalamic MRI objectified an atrophic anterior pituitary gland in two cases. Hormonal substitutive therapy was started in all patients. Recombined human GH treatment was introduced in one case, but omitted in two others cases for bad control of the cancerous disease and for an achieved puberty in the fourth patient.
Conclusion: The search of the hormonal deficiencies is essential for any child treated by craniospinal radiotherapy in order to institute an early hormonal substitutive therapy.
Keywords: Craniospinal radiotherapy, hormonal deficiencies, substitutive therapy
The influence of covid 19 on screening and management of colorectal cancers, case study of the agadir oncology centre
Authors: Ouaamr Ahmed , Fechtali Taoufiq 
Published: February 2022

Colorectal cancer (CRC) is the 3rd cancer in the world after lung cancer and breast cancer, its incidence has increased over the past decade. It occupies the first place among digestive cancers in Morocco (40.3%), However, given the absence of a national cancer registry, there is no epidemiological data on all of Morocco. Based on data from the Greater Casablanca Cancer Registry (RCRC), the annual national cancer incidence is estimated at 101.7 new cases per 100,000 populations, which would equate to 30,500 new cancer cases each year.
In terms of frequency by sex, colorectal cancer is the second most common cancer in women and the third most common in men. It has significant human and financial consequences. Despite therapeutic and preventive advances, which have reduced mortality due to colorectal cancer, colorectal cancer still kills people around the world.
However, the advent of the Covid 19 pandemic has caused a delay in screening and a disruption in management, this article summarizes the main results of this delay and the risks on the evolution of colorectal cancers. The study is carried out at the Regional Oncology Centre of Agadir (CRO).
Keywords: screening, management, Covid 19, colorectal cancer.
Assessment of knowledge and attitudes towards epilepsy of a sample of Moroccan population at Ibn Rochd University hospital of Casablanca
Authors: Hajji E B , Bellakhdar S , Hassoune S , Rafai M A , Lakhdar A 
Published: February 2022

Epilepsy is among the most common neurological pathologies, affecting around 50 -70 million people from all populations worldwide. A high prevalence is estimated in underdeveloped and developing countries. Our aim is to assess the perception and knowledge of a sample of Moroccan population towards epilepsy. Epileptic and non-epileptic patients companying, were interviewed and a questionnaire on knowledge and attitudes about epilepsy was completed, in Neurological and Neurosurgical departments of Ibn Rochd University Hospital of Casablanca. Our results show that 5.7% of our group never heard of epilepsy. 26.3% have no idea about his neurological nature, while 52.5% attribute it to supernatural causes. 13,1% believe epilepsy is incurable, 13,1% doubt about its curability and 9,1% suppose it to be a disease of "insanity". Moreover, 5,1% consider that non-medical approaches (plants, marabouts and ''witchcraft'') as good first-line choices, while 31,6% who choose medicine first, intend to move towards these non-medical practices after a supposed ineffectiveness of the medical treatment. Therefore, our analysis reports that age (over 50), sex (women), area of residence (rural), source of information (general entourage) and the existence or not of an epileptic case in the family, are the main significant determining factors of the perception of our population on epilepsy. According to these preliminary results, we estimate that the consequences of such perception would lead to an inadequate management of an important part of patients, and certainly, more therapeutic difficulties and more complications. This highlights the interest of a good public awareness about this neurological disorder.
Keywords: Knowledge, Attitudes, Epilepsy, Moroccan, Practices.
Huntington disease and the mechanisms of neuronal death
Authors: Berrada Sarah , Bouzroud Wafaa , Tazzite Amal , Dehbi Hind 
Published: February 2022

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansions in the Huntington HTT gene inherited in an autosomal dominant manner. It is characterized by a motor, cognitive and psychiatric symptoms that progress to death within 10-20 years. Herein we report two families with a dysfunction in the HTT gene causing a motor progression and cognitive deterioration. Indeed, both affected patients reported similar symptomatology characterized by involuntary movements (chorea), general motor impairment, depression and cognitive disorder. In order to detect the CAG-repeat in the HTT gene, a real time PCR analysis was performed. The diagnosis was confirmed because of the presence of a CAG trinucleotide repeat expansions in the HTT gene exceeding 35 repetitions. Thereby, the genetic counselling has been established and recommended for the other family members.
The HTT gene localized on 4p16.3 encodes for Huntington protein. CAG trinucleotide expansion in the HTT gene encodes for an abnormal polyglutamine tract in the huntingtin protein. The Huntington disease manifests when the number of the triplet is more than 35 repetitions causing an apoptosis in striatal neurons with a dysfunction in cytoplasm functions. The exact molecular mechanism by which the mutant huntingtin protein induces cell death as well as its function are not totally understood. Genetic confirmation of the diagnosis is important for patient’s management and genetic counselling. Many therapeutic options are available for treating symptoms with a focus on life quality improve.
Keywords: Huntington disease, Triplet expansion, Neuronal apoptosis.
Atmospheric CO2 estimates for the Miocene to Pleistocene based on foraminiferal δ11B at Ocean Drilling Program Sites 806 and 807 in the Western Equatorial Pacific
Authors: Guillermic Maxence , Misra Sambuddha , Eagle Robert , Tripati Aradhna 
Published: February 2022

Abstract. Constraints on the evolution of atmospheric CO2 levels throughout
Earth's history are foundational to our understanding of past variations in
climate. Despite considerable effort, records vary in their temporal and
spatial coverage and estimates of past CO2 levels do not always
converge, and therefore new records and proxies are valuable. Here we
reconstruct atmospheric CO2 values across major climate transitions
over the past 16 million years using the boron isotopic composition (δ11B) of planktic foraminifera from 89 samples obtained from two sites
in the West Pacific Warm Pool, Ocean Drilling Program (ODP) Sites 806 and
807, measured using high-precision multi-collector inductively coupled plasma
mass spectrometry. We compare our results to published data from ODP Site
872, also in the Western Equatorial Pacific, that goes back to 22 million
years ago. These sites are in a region that today is near equilibrium with
the atmosphere and are thought to have been in equilibrium with the
atmosphere for the interval studied. We show that δ11B data
from this region are consistent with other boron-based studies. The data
show evidence for elevated pCO2 during the Middle Miocene and Early to
Middle Pliocene, and reductions in pCO2 of ∼200 ppm
during the Middle Miocene Climate Transition, ∼250 ppm during
Pliocene Glacial Intensification and ∼50 ppm during the
Mid-Pleistocene Climate Transition. During the Mid-Pleistocene Transition
there is a minimum pCO2 at marine isotopic stage (MIS) 30. Our results are consistent with a
coupling between pCO2, temperature and ice sheet expansion from the
Miocene to the late Quaternary.
SISTEM PENGAMANAN MESIN ATM DENGAN MENGGUNAKAN PENGENALAN SIDIK JARI DAN WAJAH FACE RECOGNITION UNTUK MEMINIMALISIR CYBERBANKING CRIME
Authors: Arifin Mohamad 
Published: February 2022

Mesin anjungan tunai mandiri (ATM) sangat mudahkan para nasabah perbankan dalam bertransaksi perbankan selama 24 jam tanpa terikat dengan jam operasional kantor bank. Nasabah cukup dengan menggunakan kartu dan memasukan nomor pin pada mesin, nasabah dapat bertransaksi non tunai dan penarikan uang. Tetapi, kelemahan mesin ATM yang menggunakan kartu sangat rawan peretasan. Biasanya, peretasan data nasabah menggunakan alat skimmer yang terpasang pada slot card mesin. Alat skimmer berfungsi untuk mencuri data nasabah termasuk nomor rekening, jumlah saldo dan nomor PIN yang tersimpan pada pita electronic magnetic (berada di bagian belakang kartu). Data nasabah yang terekam dapat digunakan para hacker untuk menngandakan kartu nasabah dan mengambil uang nasabah dengan kartu atm duplikat. Tindakan haker tersebut sangat merugikan nasabah. Oleh sebab itu, diperlukan pengamanan mesin ATM yang bersifat biometric atau melekat pada diri manusia yaitu sidik jari dan wajah. Hal tersebut karena bentuk atau pola sidik jari manusia tidak sama antara satu individu dengan lainnya, begitu juga dengan wajah yang memiliki tingkat akurasi yang tinggi. Metode dalam penelitian terbagi dua yaitu pengumpulan data pendukung melalui studi literature tentang topik terkait dan selanjutnya perancangan grafis prototype mesin ATM dengan menggunakan pengenalan sidik jari dan wajah. Cara operasional yang dilakukan, nasabah melakukan perekaman sidik jari dan wajah ke kantor bank. Selanjutnya, petugas bank menvalidasi dengan data kependudukan yang memuat informasi biometrics nasabah. Jika sudah tervalidasi lalu petugas bank mensikronisasikan dengan rekening nasabah dan proses selesai. Nasabah dapat bertransaksi pada mesin ATM tanpa menggunakan kartu ATM. Cukup melakukan verifikasi sidik jari dan wajah pada mesin adapun output dari penelitian ini untuk meminimilisir tingkat kejahatan cyberbanking.
Fuzzy Hyers-Ulam-Rassias stability for generalized additive functional equations
Authors: Zamani Zahra , Yousefi Bahman , Azadi Kenary Hassan 
Published: February 2022

In this paper we establish Hyers-Ulam-Rassias stability of a generalized functional equation in fuzzy Banach spaces. The concept of Hyers-Ulam-Rassias stability originated from Th. M. Rassias stability theorem that appeared in his paper: On the stability of the linear mapping in Banach spaces, Proc. Amer. Math. Soc. 72 (1978), 297-30.
Results of two-stage plasty in severe consequences of burns of the upper extremity
Authors: Mirzoev N. M. , Khojamuradov G. M. , Shamonov N. H. , Ziyozoda S. S. , Odinaev B. A. , Shamsov N. H. 
Published: February 2022

Aim. To study the immediate and long-term results of the use of non-free flaps in the treatment of patients with the consequences of burns of the upper limb.Material and methods. The study included 32 patients with the consequences of burns of the upper limb, who were admitted to the Republican Scientific Center of Cardiovascular Surgery in the period from 2003 to 2020. The age of the patients ranged from 4 to 32years, the average value was 19.6 ± 1.9 years.Results. There were no intraoperative complications. The average volume of blood loss during one operation was 125.6 ± 11.3 ml (determined by squeezing napkins). The average duration of the operation was 128.6 ± 15.7 minutes. There were no complications after transplantation of a non-free inguinal flap. To achieve a more acceptable aesthetic result, a non-free radial flap was used in a period of five to fifteen years after the primary operation.Conclusion. Thus, the observance of surgical staging depending on the prevalence of one or another lesion component is decided individually and the principles of reconstruction of important anatomical structures shall be strictly followed.
Peculiarities of treatment and prevention in patients with type 2 diabetes mellitus with osteoporotic disorders in a region with a high birth rate
Authors: Muzafarova M. E. 
Published: February 2022

Aim. To review the experience of managing patients with type 2 diabetes mellitus complicated by osteoporotic changes in a region with a high birth rate.Materials and methods. We observed 110 patients with type 2 diabetes - 55 women with a normal parity, 55 women with a high parity in history. The control group consisted of 55 women of the same age who did not suffer from type 2 diabetes. The parameters of lipid, phosphorus-calcium metabolism, vitamin D, and markers of bone remodeling were studied. The method of dual-energy X-ray absorptiometry with an osteodensitometer was used to assess the possible loss of bone tissue.Results. The choice of treatment tactics for patients with type 2 diabetes was based on the baseline level of glycated hemoglobin (HbA1c) and main clinical symptoms. When the level of glycated hemoglobin was more than 7% (7.5-8.0), metformin monotherapy was prescribed. At initially high levels of HbA1c (8-9%), a combination of antihyperglycemic drugs was prescribed (glipizide in combination with metformin; DPP-4-alogliptin inhibitor with metformin). In the group of patients with baseline HbA1c levels (9-9.5%), therapy with GLP-1 (liraglutide) was carried out. Over the past year, a new antihyperglycemic drug from the group and NGLT-2 (dapagliflozin) was tested. Its mechanism is based on a decrease in the reabsorption of glucose in kidneys. Stable preservation of the reduced HbA1c was noted against the background of combined use with metformin. Following osteoporotic drugs were used: Zolendronic acid (Aklasta), denosumab, teriparatide.Conclusion. An individual treatment approach to patients with type 2 diabetes complicated by osteoporotic disorders through the combined use of hypoglycemic and osteotropic medicines gave a positive result. Prevention of osteoporotic changes in patients with type 2 diabetes of the postmenopausal period should be comprehensive, taking into account the maintenance of the glycemic level under the control of the HbA1c content ≤ 7%, the fight against complications of diabetes mellitus, the inclusion of regular dosed physical exercises and additional measures taking into account the multiple births factor.