bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a biomarker of peripheral stress in opioid addicts based on the hypothalamic-pituitary-adrenal axis—The improvement effect of exercise
Authors: Wang Jingsong , Zou Zhibing 
Published: December 2022

PurposeThis study aims to investigate the relationship between peripheral blood oxytocin (OT), vasopressin (AVP), and subjectively perceived stress and cortisol in male opioid addicts based on the hypothalamic-pituitary-adrenal (HPA) axis. We also investigate the impact of exercise on reducing subjectively perceived stress, craving level, negative reinforcement, anxiety, sleep quality, plasma OT, AVP, and cortisol levels.MethodsParticipants were divided into 28 subjects in the low-stress control group (LSC group), 29 subjects in the medium-high stress control group (MTHSC group), and 28 subjects in the moderate-high-stress exercise group (MTHSE group), based on their subjectively perceived stress levels. Subjects in the MTHSE group performed 12 weeks of combined aerobic resistance training (60 min per day, 5 days per week). Plasma OT, AVP, and cortisol concentrations were analyzed via Elisa. PSQI was used to assess the subjective perceived stress, craving, negative reinforcement, anxiety, and sleep quality level, respectively. Mixed-effects ANOVA and Pearson correlation analysis were employed to explore the impact and correlation between different parameters.ResultPlasma OT levels significantly increased (95% CI: –7.48, –2.26), while plasma AVP (95% CI: 2.90, 4.10), and cortisol (95% CI: 19.76, 28.17) levels significantly decreased in the MTHSE group after exercise. The PSS (95% CI: 1.756, 4.815), “Desire and Intention” (95% CI: 1.60, 2.71), and “Negative reinforcement” (95% CI: 0.85, 1.90) (DDQ), SAS (95% CI: 17.51, 26.06), and PSQI (95% CI: 1.18, 3.25) scores of the MTHSE group were significantly decreased after exercise. Plasma OT, plasma cortisol, craving, negative reinforcement and anxiety were negatively correlated. Plasma AVP was positively correlated with craving.ConclusionAs an auxiliary treatment, exercise improves the plasma OT, AVP, and cortisol levels of opioid addicts, and reduces their subjective perceived stress level, desire, negative reinforcement level, anxiety level, and sleep quality. In addition, peripheral plasma OT, AVP, and cortisol may play a role as potential peripheral biomarkers to predict stress in male opioid addicts.
Efficacy of psychotherapy in subthreshold depression patients: A protocol for an overview of systematic reviews and meta-analyses
Authors: Han Xu , Li Jiaxin , Yang Yajie , Liu Jiaxin , Zhang Jinzi , Han Xiao , Reyila Abudurousuli , Liu Zhizhong , Ge Pu 
Published: December 2022

BackgroundSubthreshold depression is a risk factor for major depression. Psychotherapy is a kind of intervention for subthreshold depression. There have been many systematic reviews synthesized the evidence for its effectiveness toward subthreshold depression. However, there is currently no overview of these systematic reviews.ObjectiveTo undertake an overview of meta-analyses and systematic reviews to identify the efficacy of psychotherapy in subthreshold depression patients.MethodsWe will search several databases such as PubMed, Embase, the Cochrane Library, Web of Science, PsycINFO, CNKI, WanFang and VIP database, for systematic reviews and meta-analyses on psychotherapy in subthreshold depression patients. The search timeline will be from inception up to August 2022. Two researchers will screen related studies back-to-back. We will include studies that evaluate the efficacy of psychotherapy in subthreshold depression patients. We will evaluate the methodological quality, the reporting quality and the quality of evidence for outcomes by AMSTAR-2, the PRISMA 2020 checklist and the GRADE grading system. We will present the results of the overview in alignment with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The anticipated start and completion dates for this overview are 1 August 2022 and 30 December 2022, respectively.ResultsFrom this study, we will evaluate the methodological quality and the level of evidence of the included systematic reviews and meta-analyses, and evaluate the efficacy of psychotherapy in patients with subthreshold depression.ImplicationsWe will ascertain the efficacy of psychotherapy in subthreshold depression patients, to provide evidence to guide the treatment of subthreshold depression in the future.Registration numberOur research protocol has been registered with PROSPERO. The registration number of the protocol is CRD42021278871.
A multiple sclerosis lifestyle behavior online course: Qualitative analysis of participants' motivations, expectations and experiences
Authors: Neate Sandra L. , Bevens William , Jelinek Pia L. , Gray Kathleen M. , Weiland T. J. , Nag Nupur , Simpson-Yap Steve , Jelinek George A. , Yu M. , Reece Jeanette C. 
Published: December 2022

BackgroundModification of lifestyle-related risk factors for multiple sclerosis (MS) has been associated with improved health outcomes when compared with standard medical management alone. Based on an existing lifestyle modification program offered as a residential workshop, the MS Online Course (MSOC) was developed to translate the workshop into an online intervention. We performed a pilot randomized controlled trial (RCT), to assess the feasibility concepts of accessibility, learnability and desirability through quantitative and qualitative analyzes. In the present study, we performed additional qualitative analyzes to explore participants' motivations, expectations, and experiences of the MSOC. This study aims to complement prior feasibility analyzes and inform recruitment strategies and course content redevelopment so that its effectiveness may be assessed by examining behavior change and health outcomes in a future larger RCT.MethodsParticipants were recruited via online advertisements and randomized to either: the standard care course, containing material sourced from public facing MS websites; or the intervention course, based on an evidence-based lifestyle modification program for people with MS. Course completers were invited to participate in semi-structured interviews. Within a qualitative paradigm, reflexive thematic analysis of interviews was undertaken.ResultsOf 31 eligible participants, 17 completed the MSOC and 14 agreed to be interviewed. Four themes were identified in this analysis: (1) “Wanting to help others” (helping through volunteering, contributing to knowledge base, spreading the word; (2) “Seeking knowledge” (confirmation of existing knowledge; obtaining new knowledge, relevant, credible information); (3) “Doing what I can to help myself” (understanding lifestyle modification, changing my lifestyle, remaining well); and (4) “Changing attitudes” (finding positivity, feeling more confident and in control).ConclusionsParticipants were motivated to help others through research, help themselves by improving knowledge and to find ways to better manage their MS. Expectations included obtaining credible, reliable information, to substantiate existing knowledge, and to further understand lifestyle modification. Participants' experiences included confirmation of and obtaining new knowledge, and early implementation of modified lifestyle behaviors. These insights surrounding participants' motivations, expectations and experiences will assist in recruitment strategies, course redevelopment and outcome measures for the future RCT to examine the effectiveness of the MSOC.
Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study
Authors: Huang Chun-Yen , Lee Jia-In , Chang Chia-Wen , Liu Yao-Hua , Huang Shu-Pin , Chen Szu-Chia , Geng Jiun-Hung 
Published: December 2022

IntroductionWe aim to explore the association between chronic kidney disease (CKD) and cataracts.MethodsA total of 121,380 participants with adequate information collected from 29 community-based recruitment centers since 2008 were analyzed. The association between CKD and self-reported diagnosed cataracts was examined in a cross-sectional cohort and was validated in a longitudinal cohort of 25,263 participants without cataracts at baseline.Results and discussionOf all participants, cataracts occurred in 503/1,947 (26%) and 10,464/119,433 (9%) subjects in the CKD and non-CKD groups, respectively. Multivariate logistic regression showed that CKD was significantly associated with a higher prevalence of self-reported diagnosed cataracts. In the validation cohort, a higher incidence of cataracts was also noted in the CKD group (65/317, 21%) compared to the non-CKD group (1,964/24,252, 8%) during a mean 47-month follow-up. After adjusting for confounders, subjects with CKD had a 1.498-fold higher risk of incident cataracts than those without CKD (95% confidence interval = 1.114 to 2.013, p value = 0.007). We found that CKD was associated with a higher prevalence of cataracts as well as incident cataracts, which suggests CKD patients and their primary physicians should be aware of this disease and can provide a clue for further exploration of the possible mechanisms and treatments.
High relatedness of bioinformatic data and realistic experimental works on the potentials of Fasciola hepatica and F. gigantica cathepsin L1 as a diagnostic and vaccine antigen
Authors: Fereig Ragab M. , Metwally Samy , El-Alfy El-Sayed , Abdelbaky Hanan H. , Shanab Obeid , Omar Mosaab A. , Alsayeqh Abdullah F. 
Published: December 2022

IntroductionFascioliasis is a parasitic foodborne disease caused by the liver flukes, Fasciola hepatica and F. gigantica. Such parasites cause serious illness in numerous domestic animals and also in humans. Following infection, the parasite secretes a variety of molecules that immediately interact with the host immunity to establish successful infection. These molecules include cathepsin L peptidase 1 (CatL1); the highly investigated diagnostic and vaccine antigens using various animal models. However, a few studies have analyzed the potentials of FhCatL1 as a diagnostic or vaccine antigen using bioinformatic tools and much less for FgCatL1. The present study provides inclusive and exclusive information on the physico-chemical, antigenic and immunogenic properties of F. hepatica cathepsin L1 (FhCatL1) protein using multiple bioinformatic analysis tools and several online web servers. Also, the validation of our employed available online servers was conducted against a huge collection of previously published studies focusing on the properties of FhCatL1as a diagnostic and vaccine antigen.MethodsFor this purpose, the secondary, tertiary, and quaternary structure of FhCatL1 protein were also predicted and analyzed using the SWISS-MODEL server. Validation of the modeled structures was performed by Ramachandran plots. The antigenic epitopes of the protein were predicted by IEDB server.Results and discussionOur findings revealed the low similarity of FhCatL1 with mammalian CatL1, lacking signal peptides or transmembrane domain, and the presence of 33 phosphorylation sites. Also, the containment of FhCatL1 for many topological, physico-chemical, immunological properties that favored its function of solubility and interaction with the immune components were reported. In addition, the earlier worldwide reports documented the high efficacy of FhCatL1 as a diagnostic and vaccine antigen in different animals. Altogether, FhCatL1 is considered an excellent candidate for using in commercialized diagnostic assays or vaccine products against fascioliasis in different animal species. Our assessment also included FgCatL1 and reported very similar findings and outputs to those of FhCatL1.
Assessing COVID-19-related health literacy and associated factors among school teachers in Hong Kong, China
Authors: Lau Sam S. S. , Shum Eric N. Y. , Man Jackie O. T. , Cheung Ethan T. H. , Amoah Padmore Adusei , Leung Angela Y. M. , Dadaczynski Kevin , Okan Orkan 
Published: December 2022

ObjectivesThe coronavirus disease 2019 (COVID-19) pandemic developed rapidly, with changing guidelines, misinformation, inaccurate health information and rumors. This situation has highlighted the importance of health literacy, especially among educators. The aims of this study were (i) to assess COVID-19-specific health literacy among school teachers in Hong Kong and (ii) to examine its association with demographic factors, self-endangering work behaviors (i.e., work intensification, work extensification and work quality reduction), secondary burnout symptoms (i.e., exhaustion related to work and psychosomatic complaints), the level of knowledge of COVID-19- or pandemic-related information and the level of confusion about COVID-19-related information.MethodsA self-report survey was administered to 366 Hong Kong school teachers from April 2021 to February 2022. COVID-19-specific health literacy was measured using the HLS-COVID-Q22 instrument. Other instruments, including self-endangering work behavior scales (i.e., extensification of work, intensification of work and work quality reduction) and two dimensions of the Burnout Assessment Tool (i.e., psychosomatic complaints and exhaustion) were also used for assessment. Data were analyzed using an independent samples Student's t-test, analysis of variance, correlation analysis and adjusted multilinear regression models.ResultsThe results showed that 50.8% of school teachers had sufficient health literacy, 38.3% had problematic health literacy and 10.9% had inadequate health literacy. The HLS-COVID score did not vary by sex, but varied according to the type of school, the number of working hours per week and the number of students attending the school. Teachers with sufficient health literacy scored significantly lower for two types of self-endangering work behavior–intensification of work (p = 0.003) and work quality reduction (p = 0.007)—than those with insufficient health literacy. After excluding those who had already been vaccinated, respondents with sufficient health literacy felt more positive about COVID-19 vaccination than those with insufficient health literacy (t[180] = 4.168, p &lt; 0.001). In addition, teachers with sufficient health literacy felt more informed (p &lt; 0.001) and less confused (p &lt; 0.001) about COVID-19-related information than those with insufficient health literacy. Multiple linear regression analysis revealed that age (β = 0.14, p = 0.011) and the number of teaching hours per week (β = −0.206, p &lt; 0.001) were significant predictors of the HLS-COVID score.ConclusionsThe findings of this study may serve as a guide for addressing health literacy gaps among school teachers.
Cropping system intensification for smallholder farmers in coastal zone of West Bengal, India: A socio-economic evaluation
Authors: Mandal Subhasis , Sarangi Sukanta Kumar , Mainuddin M. , Mahanta K. K. , Mandal Uttam Kumar , Burman D. , Digar S. , Sharma P. C. , Maji B. 
Published: December 2022

IntroductionIt is estimated that five out of six farms in the world are operating less than two hectares of land, called smallholder farmers, and they are producing over one third of the global food. Cropping system intensification research and interventions at farmers' fields could be one of the ways to improve the prevailing cropping systems. Understanding socio-economic issues are important for the successful implementation of improved or new cropping systems and for increasing farmers' income in the coastal zone of the Ganges delta. A socio-economic evaluation study was carried out to understand how far the suggested cropping options were feasible to smallholder farmers in the coastal zone; quantify the benefits due to the adoption of new cropping systems; how far those options were socio-economically suitable for the targeted smallholder farmers; and to identify the key factors that might be affecting the out-scaling of the evolved options to a larger group of farmers.MethodsBaseline and endline surveys were conducted with 90 farmers before and after the demonstration of various cropping systems at farmers' fields. Techno-economic suitability of new crops and management options were evaluated through accounting benefits of adoption and identifying various constraints in adoption. Behavioral analysis was carried out to identify factors affecting large-scale adoption of the new/improved cropping systems evolved.Results and discussionThe socio-economic survey quantified the increase in cropping intensity higher than the baseline level (123–142%) and reduced the rabi (winter/dry) season fallow area by 30–35%. The study identified farmers' preferred interventions were low-cost drip irrigation and mulching, zero-tillage (ZT) potato with straw mulching, improving soil quality with lime and green manuring, and vegetable-based cropping systems interventions. Although the economics of the evolved cropping systems were favorable, however, availability of freshwater stored in ponds/canals, and income from on and off-farm were the most important factors determining the adoption of new systems on a larger scale.
Performance of a Vector-Controlled PMSM Drive without Using Current Sensors
Authors: Badini Sai Shiva , Verma Vimlesh , Tariq Mohd , Urooj Shabana , Mihet-Popa Lucian 
Published: December 2022

The current sensorless vector-controlled permanent-magnet synchronous motor (PMSM) drive using a single sensor (i.e., speed sensor) is presented in this work. The current sensors are removed, and the estimated currents are used to close the current loop to minimize the drive cost and make it fault-tolerant against current sensor failure. A classical vector-control PMSM drive requires at least three sensors, i.e., two current sensors and one speed/position sensor. This paper presents a new current estimation technique that is free from inverter switching states, an integrator, and differentiator terms. The drive is suitable for retrofit applications, as it does not require any additional hardware. The reference voltages (vds and vqs) are used to estimate the rotor reference frame currents (i.e., iqs and ids). The presented algorithm depends on the stator resistance (Ɍs). The online Ɍs estimation algorithm is used for compensation to overcome the effect of the Ɍs on the estimated currents. The sensitivity analysis for the currents against the speed is verified and presented. The speed loop is closed with actual speed information, which will try to maintain the reference speed under any circumstances. The proposed current sensorless PMSM drive was validated using MATLAB/Simulink and also verified on a hardware prototype. The presented technique was verified for various operation conditions, and some of the extensive results are presented.
Detection of Echinococcus granulosus sensu lato in Environmental Samples from Ibadan, Oyo State, South West Nigeria
Authors: Awosanya Emmanuel Jolaoluwa , Olagbaju Adeola , Peruzzu Angela , Masu Gabriella , Masala Giovanna , Bonelli Piero 
Published: December 2022

Environmental contamination with parasite eggs poses a serious risk to public health. This study aimed to assess the presence of taeniid eggs and, in particular, E. granulosus s.l., in environmental samples in the city of Ibadan, South West Nigeria. To this purpose, soil (n = 200), fecal (n = 200) and water samples (n = 50) were examined by microscopic observation and the multiplex PCR method. The influence of specific environmental factors on E. granulosus s.l. egg dispersion was also evaluated. Taeniid eggs were microscopically found in 11.5%, 25.5% and 8.0% of soil, fecal and water samples, respectively. PCR analyses evidenced the presence of E. granulosus s.l. in 8.0%, 24.0% and 2.0% of soil, fecal and water samples, respectively. The proximity to slaughterhouses, the level of urbanisation and the local government area of belonging did not seem to affect E. granulosus s.l. egg dissemination patterns. Our results have clearly demonstrated that both urban and semi-urban areas of the city of Ibadan in Nigeria are highly contaminated by taeniid eggs and we recommend the adoption of appropriate measures to control E. granulosus s.l.
Melanoníquia de aparecimento súbito em paciente jovem - relato de caso e revisão de literatura
Authors: Reghin Cibele Regina de Souza , Piveta Giovana , Penha Mariana Alvares , Lastória Joel Carlos 
Published: December 2022

A melanoníquia refere uma pigmentação na lâmina-ungueal, caracterizada por uma coloração marrom-escuro, devido a ativação melanocítica, sendo preocupante para a maioria dos pacientes. Pode se desenvolver em qualquer idade, em uma única unha ou em múltiplas. Sua prevalência é maior em pessoas de pele escura e em afrodescendentes maiores de 20 anos, acometendo cerca de 77% da população. Sua localização mais frequente é nas unhas do primeiro e segundo dedos das mãos estando relacionada a utilização mais frequente destes dedos, tendo assim maior possibilidade de traumatismos.
A melanoníquia pode ser originada a partir de uma ativação melanocítica benigna, por conta da exposição a pigmentos exógenos ou até mesmo trauma. Além disso, ela pode ser causada por alterações melanocíticas malignas, como o melanoma. A etiologia da melanoníquia varia de acordo com a sua causa, apresentando difícil diagnóstico clínico. Por esse motivo, é necessário entender a epidemiologia, fisiopatologia e os achados clínicos do paciente. Embora a maioria dos casos tenha causas benignas, o diagnóstico precoce da lesão maligna fornece resultados mais favoráveis no prognóstico. Nesse sentido, a dermatoscopia deve ser utilizada na rotina de avaliação de lesões ungueais pigmentadas, e quando necessário faz-se biópsia e exame histopatológico para confirmação diagnóstica. Apesar do auxílio que a regra do ABCDEF trouxe, bem como o exame dermatoscópico, a análise anatomopatológica continua indispensável em casos duvidosos. A exérese da lâmina ungueal é de extrema importância para avaliação diagnóstica, pois permite observar a matriz e o leito ungueal, possibilitando um maior dimensionamento e precisão da lesão. Assim, o objetivo deste relato é a revisão de literatura sobre melanoníquia, discussão de seus diagnósticos diferenciais, como também a apresentação de um caso típico.
PENGARUH TOTAL ASET EARNING PER SHARE DAN DEVIDEND PER SHARE TERHADAP HARGA SAHAM PERUSAHAAN PERDAGANGAN YANG GO PUBLIC DI BURSA EFEK INDONESIA
Authors: Alfiansyah  
Published: December 2022

Abstrak :Penelitian ini bertujuan untuk mengetahui pengaruh total aset, earning per share dan devidend per Share terhadap harga saham perusahaan perdagangan yang go public di bursa Efek Indonesia .sumber data sekunder dalam penelitian ini adalah data yang diperoleh dari laporan keuangan yang ada di bursa efek Indonesia, metode analisis dalam penelitian ini adalah dengan menggunakan analisis Linier Berganda menggunakan program SPSS for Windos versi 25 proses analisis jalur telah diuji dan realibilitas serta asumsi klasik. Hasilnya semua memenuhi kriteria untuk diteruskan pada tahap analisis linier berganda. berdasarkan hasil Penelitian total aset, earning per share dan devidend per share berpengaruh Secara simultan terhadap harga saham perusahaan perdagangan yang go public di bursa efek indonesia. Kemudian Nilai R dengan nilai sebesar 0,862 atau 86,2% adalah koefisien korelasi yang menunjukkan tingkat hubungan yang sangat tinggi

Kata kunci: Total Aset, Earning per Share Devidend per Share Harga Saham