bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontline Therapy in Mantle Cell Lymphoma: When Clinical Trial and Real-World Data Collide
Authors: Fenske Timothy S. 
Published: September 2022

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice.A large number of frontline treatment options exist for mantle cell lymphoma (MCL), making selection of therapy a challenge for the clinician. In this Oncology Grand Rounds article, the case of a 73-year-old woman with MCL who attained remission with bendamustine and rituximab is presented. The relevant literature regarding frontline therapy is then reviewed, with particular focus on selection of induction regimen and the potential roles for autologous transplantation and/or rituximab maintenance. This literature primarily consists of prospective phase 2 and phase 3 clinical trials; however, added to this literature now is a growing body of large retrospective real-world cohorts, such as the new analysis by Martin et al,35the manuscript that accompanies this Oncology Grand Rounds article. In some cases, the real-world evidence is at odds with data from prospective clinical trials, such as regarding the role of rituximab maintenance after bendamustine plus rituximab induction. These important new real-world data are put into context of an ever-changing treatment landscape, in hopes of aiding clinicians in frontline treatment selection for patients with MCL.
Transfiguration as a World-Making Practice: From Norman O. Brown to Bob Dylan
Authors: Wilson Rob 
Published: September 2022

Abstract
By a transfigurative recoding of selfhood and quasi-biblical analogizing of historical events across space and time, Bob Dylan enacted in his poetic name change from Zimmerman to Dylan (as he would writing across the larger body of his song-poetry) what Norman O. Brown had embraced, in Love's Body and Apocalypse and/or Metamorphosis if not throughout his works early and late, as tactics of “figural interpretation, [that] discovered world-historical significance in any [everyday trivial] event—an event which remains trivial for those who do not have eyes to see.” Transfiguration for Brown was not merely a figural, intertextual, or rhetorical shift of tropes, as will be elaborated; it also implies more strongly a biomorphic metamorphosis of self and world, soul and matter, bios and logos, via the morphological and linguistic transformation of terms and forms. Such metaphoric twists and troping turns of metamorphosis aim to remake the world into fluid, multiple forms of becoming befitting what a flourishing Romantic imagination longs for (via transubstantiation) and what Brown defines (and Dylan performs as) feats of transfigurative metamorphosis: “Metamorphosis, or transubstantiation.” “Transubstantiate my form, says Daphne [as muse to Apollo, archetypal Greco-Roman poet].” In this essay, Brown will play Daphne provoking and inspiring in figures like Apollo what he terms as the “be leafing” (believing) patterns in a world-transforming visionary poet like Bob Dylan.
Pedagogy: An Introduction to the Book of Ours
Authors: Hall Nor 
Published: September 2022

Abstract
This introduction to the Book of Ours tells stories of the processes of its production and the efforts made regarding its publication. The Book of Ours, a handwritten and hand-drawn workbook, was designed by Norman O. Brown and Nor Hall to accompany eight labyrinthine lectures on Hesiod and the Homeric Hymns that Brown gave for his “To Greet the Return of the Gods” class of 1970 and 1971. The workbook introduced undergraduates to the Greek alphabet, gave references for lecture material written on the blackboard, and provided a bibliography. Intended as a pedagogical tool, each page lent annotated white space for notes, musings, and poetic utterance.
Hymn to the Muses: To Greet the Return of the Gods, Part 1 (Lecture 2, Book of Ours)
Authors: Brown Norman O. 
Published: September 2022

Abstract
This lecture, a tribute to the Muses, was delivered by Norman O. Brown for his class of 1971, “To Greet the Return of the Gods.” It is spoken with the preacher's rhythmic diction and charmed hieratic voice, and is transcribed here to include Brown's intentional pauses, halting rhythms, repetitions, asides, and idiosyncratic quotes. As in the Orphic tradition, the professor becomes what he's professing: Brown teaches us to sing a love song according to the Muses, finding the meaning in the singing and in the etymology of the names of the divine sisters. Brown's nearly liturgical list of names is propelled by devotion to the feminine and to language, above all to Kalliopê, chiefest of Muses. The gift of the Muses to mortals, Brown argues, is a poetical politics essential in the ongoing iron age described by Hesiod. Poetry as prayer—yet the Muses make it new, “so everything can shine again.”
The Knosp Criteria Revisited: 3-Dimensional Volumetric Analysis as a Predictive Tool for Extent of Resection in Complex Endoscopic Pituitary Surgery
Authors: DiRisio Aislyn C. , Feng Rui , Shuman William H. , Platt Samantha , Price Gabrielle , Dullea Jonathan T. , Gilja Shivee , D'Andrea Megan R. , Delman Bradley N. , Bederson Joshua B. , Shrivastava Raj K. 
Published: September 2022

BACKGROUND:
The Knosp criteria have been the historical standard for predicting cavernous sinus invasion, and therefore extent of surgical resection, of pituitary macroadenomas. Few studies have sought to reappraise the utility of this tool after recent advances in visualization and modeling of tumors in complex endoscopic surgery.

OBJECTIVE:
To evaluate our proposed alternative method, using 3-dimensional (3D) volumetric imaging, and whether it can better predict extent of resection in nonfunctional pituitary adenomas.

METHODS:
Patients who underwent endoscopic transsphenoidal resection of pituitary macroadenomas at our institution were reviewed. Information was collected on neurological, endocrine, and visual function. Volumetric segmentation was performed using 3D Slicer software. Relationship of tumor volume, clinical features, and Knosp grade on extent of resection was examined.

RESULTS:
One hundred forty patients were identified who had transsphenoidal resection of nonfunctional pituitary adenomas. Macroadenomas had a median volume of 6 cm3 (IQR 3.4-8.7), and 17% had a unilateral Knosp grade of at least 3B. On multiple logistic regression, only smaller log-transformed preoperative tumor volume was independently associated with increased odds of gross total resection (GTR; odds ratio: 0.27, 95% CI: 0.07-0.89, P < .05) when controlling for tumor proliferative status, age, and sex (area under the curve 0.67). The Knosp criteria did not independently predict GTR in this cohort (P > .05, area under the curve 0.46).

CONCLUSION:
Increasing use of volumetric 3D imaging may better anticipate extent of resection compared with the Knosp grade metric and may have a greater positive predictive value for GTR. More research is needed to validate these findings and implement them using automated methods.
The Muscle Morphology of Elite Female Sprint Running
Authors: MILLER ROBERT , BALSHAW THOMAS G. , MASSEY GARRY J. , MAEO SUMIAKI , LANZA MARCEL B. , HAUG BILL , JOHNSTON MICHAEL , ALLEN SAM J. , FOLLAND JONATHAN P. 
Published: September 2022

ABSTRACT

Introduction
A paucity of research exists examining the importance of muscle morphological and functional characteristics for elite female sprint performance.

Purpose
This study aimed to compare lower body muscle volumes and vertical jumping power between elite and subelite female sprinters and assess the relationships of these characteristics with sprint race and acceleration performance.

Methods
Five elite (100 m seasons best [SBE100], 11.16 ± 0.06 s) and 17 subelite (SBE100, 11.84 ± 0.42 s) female sprinters underwent: 3T magnetic resonance imaging to determine the volume of 23 individual leg muscles/compartments and five functional muscle groups; countermovement jump and 30 m acceleration tests.

Results
Total absolute lower body muscle volume was higher in elite versus subelite sprinters (+15%). Elite females exhibited greater muscle volume of the hip flexors (absolute, +28%; relative [to body mass], +19%), hip extensors (absolute, +22%; relative, +14%), and knee extensors (absolute, +21%), demonstrating pronounced anatomically specific muscularity, with relative hip flexor volume alone explaining 48% of sprint performance variability. The relative volume of five individual muscles (sartorius, gluteus maximus, adductor magnus, vastus lateralis, illiopsoas) were both distinct between groups (elite > subelite) and related to SBE100 (r = 0.553–0.639), with the combination of the sartorius (41%) and the adductor magnus (17%) explaining 58% of the variance in SBE100. Elite female sprinters demonstrated greater absolute countermovement jump power versus subelite, and absolute and relative power were related to both SBE100 (r = −0.520 to −0.741) and acceleration performance (r = 0.569 to 0.808).

Conclusions
This investigation illustrates the distinctive, anatomically specific muscle volume distribution that facilitates elite sprint running in females, and emphasizes the importance of hip flexor and extensor relative muscle volume.
Effects of Endurance Training on Metabolic Enzyme Activity and Transporter Proteins in Skeletal Muscle of Ovariectomized Mice
Authors: TAKAHASHI KENYA , KITAOKA YU , MATSUNAGA YUTAKA , HATTA HIDEO 
Published: September 2022

ABSTRACT

Purpose
Estrogen deficiency or insufficiency can occur under several conditions, leading to negative health outcomes. To establish an effective countermeasure against estrogen loss, we investigated the effects of endurance training on ovariectomy (OVX)-induced metabolic disturbances.

Methods
Female Institute of Cancer Research mice underwent OVX or sham operations. On day 7 of recovery, the mice were randomized to remain either sedentary or undergo 5 wk of treadmill running (15–20 m·min−1, 60 min, 5 d·wk−1). During week 5 of the training, all animals performed a treadmill running test (15 m·min−1, 60 min).

Results
After the experimental period, OVX resulted in greater gains in body mass, fat mass, and triglyceride content in the gastrocnemius muscle. OVX enhanced phosphofructokinase activity in the plantaris muscle and decreased lactate dehydrogenase activity in the plantaris and soleus muscles. OVX decreased the protein content of NDUFB8, a mitochondrial respiratory chain subunit, but did not decrease other mitochondrial proteins or enzyme activities. Endurance training significantly enhanced mitochondrial enzyme activity and protein content in the skeletal muscles. Although OVX increased the respiratory exchange ratio during the treadmill running test, and postexercise blood lactate levels, endurance training normalized these parameters.

Conclusions
The present findings suggest that endurance training is a viable strategy to counteract the negative metabolic consequences in hypoestrogenism.
Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence
Authors: WANIGATUNGA AMAL A. , CHIU VENUS , CAI YURUN , URBANEK JACEK K. , MITCHELL CHRISTINE M. , MILLER EDGAR R. , CHRISTENSON ROBERT H. , REBUCK HEATHER , MICHOS ERIN D. , JURASCHEK STEPHEN P. , WALSTON JEREMY , XUE QIAN-LI , BANDEEN-ROCHE KAREN , APPEL LAWRENCE J. , SCHRACK JENNIFER A. 
Published: September 2022

ABSTRACT

Introduction
Low physical activity is a criterion of phenotypic frailty defined as an increased state of vulnerability to adverse health outcomes. Whether disengagement from daily all-purpose physical activity is prospectively associated with frailty and possibly modified by chronic inflammation—a pathway often underlying frailty—remains unexplored.

Methods
Using the Study to Understand Fall Reduction and Vitamin D in You data from 477 robust/prefrail adults (mean age = 76 ± 5 yr; 42% women), we examined whether accelerometer patterns (activity counts per day, active minutes per day, and activity fragmentation [broken accumulation]) were associated with incident frailty using Cox proportional hazard regression. Baseline interactions between each accelerometer metric and markers of inflammation that include interleukin-6, C-reactive protein, and tumor necrosis factor-alpha receptor 1 were also examined.

Results
Over an average of 1.3 yr, 42 participants (9%) developed frailty. In Cox regression models adjusted for demographics, medical conditions, and device wear days, every 30 min·d−1 higher baseline active time, 100,000 more activity counts per day, and 1% lower activity fragmentation was associated with a 16% (P = 0.003), 13% (P = 0.001), and 8% (P < 0.001) lower risk of frailty, respectively. No interactions between accelerometer metrics and baseline interleukin-6, C-reactive protein, or tumor necrosis factor-alpha receptor 1 were detected (interaction P > 0.06 for all).

Conclusions
Among older adults who are either robust or prefrail, constricted patterns of daily physical activity (i.e., lower total activity minutes and counts, and higher activity fragmentation) were prospectively associated with higher risk of frailty but not modified by frailty-related chronic inflammation. Additional studies, particularly trials, are needed to understand if this association is causal.
The validity and reliability test of the leprosy life quality questionnaire in leprosy patients
Authors: Widasmara Dhelya , Ekasari Dhany Prafita , Basuki Santosa , Atif Muhammad Mazaya , Bhat M Ramesh 
Published: September 2022

Background: Leprosy is a public health problem because it potentially affects social life. In 2018, World Health Organisation (WHO) reported that Indonesia ranks third of new cases leprosy. Leprosy significantly influences patients' quality of life. Until now, there is still no specific questionnaire to assess the quality of life for leprosy patients. Leprosy Quality of Life Questionnaire (KUKUH) is a questionnaire to assess leprosy patients' quality of life, which includes questions about psychology, physical health, social environment, and treatment. The study aimed to assess the validity and reliability of the Leprosy Quality of Life Questionnaire (KUKUH) as a tool to assess the quality of life of leprosy patients in Indonesia. Methods: The study was conducted at Saiful Anwar General Hospital in Malang, East Java. The validity analysis using construct validity with a minimum correlation coefficient value considered valid by 0.3. Internal consistency assessment for the questionnaire utilized the Cronbach α value where a value greater than or equal to 0.60 is acceptable, and a value greater than or equal to 0.80 is considered good. Results: Based on the result of variable validity test, all items measuring each aspect have item correlation coefficient values with a total score (riT) > table correlation value (0.361). The results of reliability testing, the items that measure each aspect of the quality-of-life variable for leprosy patients have Cronbach's Alpha values greater than 0.6. Conclusion: The validity test results of KUKUH Questionnaire are considered quite good, with a total score of 0.361 for the correlation coefficient for each question in KUKUH. The reliability test results were deemed satisfactory, with Cronbach's alpha > 0.6. The KUKUH questionnaire can be used to evaluate the quality of life of leprosy patients in Indonesia.
Therapeutic effect of herbal infusion on abnormal uterine bleeding: interventional non-randomized pilot study
Authors: Selmi Mejda , Lassoued Latifa , Bannour Badra , Chbili Chahra , Ben Fredj Maha , Charfeddin Ridha , Khairi Hedi 
Published: September 2022

Background: Abnormal uterine bleeding-menometrorrhagia due to uterine myomas is a health problem affecting women’s quality of life and it is considered a frequent cause of emergency visits for women. If first line medication fails to treat symptoms, surgical procedures, such as hysterectomy could be indicated, which could interfere with women's physical, social, emotional, and material quality of life. The purpose of this pilot study was to investigate the effect of a mixture of two medicinal plants, Mentha pulegium L and Artemisia abrotanum L, on 13 women with menometrorrhagia, who were candidates for hysterectomy. Methods: The herbs were taken as a tea infusion by the oral route. A total of 5 g of the dried aerial parts of the mixture were added to 100 ml of boiling water and the tea infusion was taken three times a day starting from the onset of menstruation for three consecutive days, and it was repeated for three consecutive months. Results: The study results showed that 10 out of the 13 women involved avoided the surgical procedures. The mean number of bleeding days declined from 11.50 (±3.77) at baseline to 7.60 (±2.11) (p=0.01). Participants confirmed a change in the bleeding intensity, regularization of their menstrual cycle, and improvement in their quality of life. Conclusions: This preliminary study explores a new approach to treat abnormal uterine bleeding- menometrorrhagia, based on tea infusion consumption of a mixture of two medicinal herbs, and it paves the way for future studies. Trial registration: This study is registered with ClinicalTrials.gov NCT05406960 (07/06/2022).
Crude oil hydrocarbons' effect on soil microbial metagenome from Niger Delta polluted soils
Authors: Okafor Chidinma Peace , Chikere Chioma Blaise , Akaranta Onyewuchi , Ntushelo Khayalethu 
Published: September 2022

Crude oil pollution is an endemic environmental problem in the Niger Delta region of Nigeria with background pollution levels greater than the regulatory intervention limit of 5000mg/kg of soil as stipulated in the Environmental Guidelines and Standards for Petroleum Industry in Nigeria (EGASPIN) in most polluted sites. Hence, the essence of this study was to evaluate the extent of damage caused by the pollutant (crude oil hydrocarbons) on the soil physicochemical parameters and microbial communities as well as to determine pollution effects on soil microbial ecosystem services. The soil microbial community composition, diversity, functional genes, and metabolic pathways were studied to evaluate the pollutant effect on soil microbiomes and their ability to utilize petroleum hydrocarbons as carbon and energy sources. Two sites Bodo (N4.620134, 7.282998E) and Ngia-Ama Tombia (N4.9816667; 7.0608333E) were chosen for the study. The America standard testing methods (ASTM International) were used in measuring physicochemical parameters of the soil influencing microbial response and pollutant behavior in the soil environment. Soil pH was measured using a pH meter, total petroleum hydrocarbons (TPH) using gas chromatography with a mass spectrophotometer (GC-MS), polycyclic aromatic hydrocarbons (PAHs) (ASTM D5412-93(2017) e1), Heavy metals analysis (ASTM D8404-21), soil texture (ASTM D6913/D6913M-17). Shotgun metagenomic analysis was used to determine microbial community composition, following “DNA extraction”, library preparation (Nextera® DNA Flex Library Prep Kit (Illumina, San Diego, CA), and sequencing using Illuminana NovaSeq® 6000. The results were analyzed using bioinformatics pipelines. The sequences generated were deposited in the European nucleotide Archive (ENA) with project accession number PRJEB53529.
Identification of selected primary bloodstream infection pathogens in patients attending Kisii level five and Homa Bay county hospitals
Authors: Kirera Ronald , Kipkirui Erick , Koech Margaret , Ombogo Abigael , Ndonye Janet , Kirui Mary , Philip Cliff Odhiambo , Kipkemoi Nancy , Odundo Elizabeth , Flynn Alexander F. , Hulseberg Christine , Walson Judd , Nganga Joseph , Kariuki Daniel 
Published: September 2022

Background: Bloodstream infection (BSI) contributes to a substantial proportion of mortality in sub-Saharan Africa and is marked by the presence of bacterial and/or fungal microorganisms in the blood. Because BSI can be life threatening, it requires a timely, reliable and accurate diagnosis. This study retrospectively analyzed data of identified BSI pathogens and compared the performance of the different diagnostic technologies used in terms of accuracy, sensitivity, turnaround time (TAT) and cost. Methods: Currently, culture followed by analytical profile index biochemical strips (API), (BioMerieux) are used as the conventional standard diagnostics in Kenyan public hospitals and labs. We compared the results of this standard to that of the BioFire FilmArray (FA) (BioFire Diagnostics) and MicroScan WalkAway-40 plus System (MS) (Beckman Coulter) used in diagnosis of BSI. The FA technology was able to identify 150/152 bacterial and yeast isolates with an overall accuracy of 99.04% (95% CI: 96.59-99.88%), sensitivity of 98.68% (95% CI: 95.33-99.84%), mean TAT of 8 hours 40 minutes per eight samples and running cost per sample of USD 140.11. The MS identified 150/152 isolates with an overall accuracy of 98.56% (95% CI: 95.86-99.70%), sensitivity of 98.68% (95% CI: 95.30-99.84%), mean TAT per sample was 42 hours and running cost per sample of USD 28.05. API detected 150/152 isolates, with an overall accuracy of 99.04% (95% CI: 96.59-99.88%), sensitivity of 98.68% (95% CI: 95.33-99.84%) and the mean TAT per sample was 53 and 103 hours for bacterial and yeast samples, respectively, with a running cost per sample of USD 28.05.Conclusions: The findings in this paper suggest that the FA and MS platforms should be able to perform adequately in Kenya referral hospitals and medical clinics as a rapid diagnostic tool.
Intermediate-Scale Laboratory Method to Qualify Heat-Delaminating Adhesives for Use in Cross-Laminated Timber
Authors: Zelinka Samuel L. , Bourne Keith J. 
Published: September 2022

Abstract
The goal of this research was to develop a simple laboratory test for examining heat delamination in cross-laminated timber (CLT) panels. The laboratory test was designed to mimic the fire tests described in Annex B of the ANSI/APA PRG-320 standard, which is required for CLT product qualification in North America. The Annex B test requires a full-sized room (2.4 by 4.9 by 2.7 m) to be constructed and exposed to a design fire scenario. In this article, we scaled the mechanical and fire loads so that they could be conducted in an intermediate-scale furnace with 1.1 m2 of exposed CLT panels. The mechanical loads were scaled to match the bending moment prescribed in the standard. The fire loads were scaled by matching the temperature profiles when an inert furnace lid was run and then matching the gas flow on all subsequent tests. Panels made from adhesives that passed the Annex B test passed the laboratory-scale test; panels that failed the Annex B test failed the laboratory test with the exception of one replicate. Correlations were found not only for CLT but also for a veneer-based mass timber panel. Measured temperature profiles within the furnace were similar to those measured near the compartment ceiling in the Annex B test. The scaled-down test in this article can be used to screen which adhesives are likely to pass the full-scale Annex B test.