bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wirksamkeit eines Adipositastherapieprogramms bei Kindern und
Jugendlichen in der Routineversorgung
Authors: Breinker Julius Lars , Biernath Marie , Sergeyev Elena , Kaspar Anika , Körner Antje , Kiess Wieland , Hilbert Anja 
Published: February 2022

ZusammenfassungAktuelle Therapiestudien zu Übergewicht und Adipositas im Kindes- und
Jugendalter berichten häufig einzelne psychologische oder somatische
Parameter. In der vorliegenden Studie wurde die Wirksamkeit einer multimodalen
Adipositastherapie in der ambulanten Routineversorgung über 12 Monate
bei N=278 Kindern und Jugendlichen (Alter 2–17 Jahre) anhand
umfassender psychologischer und somatischer Parameter untersucht. Als
primärer Endpunkt wurde die objektiv ermittelte Veränderung des
BMI-SDS (Body Mass Index Standard Deviation Score) festgelegt. Sekundäre
Endpunkte umfassten die selbstberichtete gesundheitsbezogene
Lebensqualität, allgemeine und Essstörungspsychopathologie,
gewichtsbezogene Selbststigmatisierung, sowie objektiv gemessene Lipoprotein-
bzw. Glukosestoffwechselparameter und Leberenzyme. Zu Therapieende nach 12
Monaten verbesserte die Gesamtstichprobe signifikant ihren BMI-SDS
(M=-0,10; SD=0,32) und einzelne Leberenzyme, psychologische
Parameter und übrige Blutparameter blieben jedoch ohne signifikante
Verbesserung. Therapieresponder (BMI-SDS-Δ≤-0,20; n=47)
zeigten größere BMI-SDS-Reduktionen (M=-0,44;
SD=0,22) sowie vergleichbare Ergebnisse hinsichtlich Blutparameter und
psychologische Parameter im Vergleich zu der Gesamtstichprobe. Die multimodale
Adipositastherapie zeigte sich damit als überwiegend wirksam für
die BMI-SDS-Reduktion und einzelne assoziierte körperliche, nicht jedoch
psychische Parameter. Die psychischen Belastungsfaktoren der Patienten
verdeutlichen die Notwendigkeit einer psychotherapeutischen Behandlung
über eine BMI-SDS-Reduktion hinaus. Weiterhin verdeutlichen die
Ergebnisse die Bedeutsamkeit einer umfassenden Erhebung von Erfolgsparametern,
um den Behandlungserfolg zu verbessern.
3D printing of multi-metallic microstructures by meniscus-confined electrodeposition
Authors: Wang Yutao , Xiong Xin , Ju Bing-Feng , Chen Yuan-Liu 
Published: February 2022

We studied a multi-metallic microscale 3D printing based on the meniscus-confined electrodeposition (MCED). The composition of Cu/Pt alloys can be controlled by applying different bias voltages to the CuSO4/H2PtCl4 mixed solution in MCED. We find that a double-barrel system had higher Cu/Pt alloy purity (maximum 100% Cu or maximum 80% Pt) than a single-barrel system. A Λ-shaped microstructure was printed to verify the capability to multi-metal microstructures in a single printing process.
The authors of the article agree to the retraction of the article effective 21 March 2023.
Line shape and light shift of coherent population trapping resonance under Ramsey interrogation in ‘hot’ atoms in an optically dense medium
Authors: Voloshin G.V. , Barantsev K.A. , Litvinov A.N. 
Published: February 2022

Abstract
A theory is developed for the effect of coherent population trapping (CPT) in ‘hot’ atoms under pulsed pumping in an optically dense medium with a buffer gas. The case is considered when the excited level is not degenerate. Based on an analysis of the shape of Ramsey resonances, we show that with increasing optical density of the medium, the dependence of the light shifts of the CPT resonance becomes more and more nontrivial. The dependence of the light shifts of the CPT resonance on the magnitude of the hyperfine splitting of the excited level, concentration of active atoms, temperature, and duration of the dark pause is constructed.
CPT resonances under multifrequency pumping
Authors: Savinov K.N. , Dmitriev A.K. , Krivetskii A.V. 
Published: February 2022

AbstractThe possibility of detecting coherent population trapping (CPT) resonances with combined microwave and HF modulation of the injection current of a diode laser has been demonstrated for the first time. A series of resonances is observed, separated from each other by half the RF modulation frequency.
Quantum optical magnetic field sensor for neurodiagnostic systems of a new generation
Authors: Petrenko M.V. , Pazgalev A.S. , Vershovskii A.K. 
Published: February 2022

Abstract
Magnetic encephalography is currently the most informative method of functional study of the brain, since, unlike other methods, it allows one to localise deep sources of biosignals and perform three-dimensional mapping of neuronal activity. The main factors hindering the development and spread of this method are the complexity and high cost of diagnostic tools, as well as the rigidity of the requirements they impose on the spatial and temporal uniformity of the magnetic field. The prospects for desinging a device capable of largely overcoming these limitations are considered. A review of studies aimed at developing an optical sensor applicable to magnetic encephalography is presented. The all-optical single-beam nonzero-field sensor proposed by the authors earlier is separately considered.
Generation of spherical laser-plasma clouds for modelling three-dimensional dynamic effects of artificial plasma injections in circumterrestrial space
Authors: Zakharov Yu.P. , Terekhin V.A. , Shaikhislamov I.F. , Posukh V.G. , Trushin P.A. , Chibranov A.A. , Berezutskii A.G. , Rumenskikh M.S. , Efimov M.A. 
Published: February 2022

Abstract
For the first time to solve the problems of laboratory modelling of cosmophysical phenomena of an explosive nature (active experiments of the AMPTE type, with barium injections into the magnetosphere), spherical laser plasma clouds (LPCs) were produced and applied (in experiments at the KI-1 test facility of the ILP SB RAS). Use was made of the classical four-beam scheme of irradiation (regular tetrahedron) of a polyethylene target ball (∅1 cm) by CO2 laser radiation with an energy of up to 500 J. A high degree of symmetry of the expansion of a near-spherical LPC with a moderate velocity of ∼100 km s−1 and an energy of up to 30 J has been achieved. The regimes of deceleration and formation of the spherical-LPC diamagnetic cavity were modelled for the first time, as well as the development of flute instability during the expansion of barium clouds across the geomagnetic field and the dynamics of these clouds along the field.
Solid-state organic laser with a wavelength tuning range of 78 nm
Authors: Tel’minov E.N. , Yacoub A.H. , Solodova T.A. , Nikonova E.N. , Kopylova T.N. 
Published: February 2022

Abstract
We report the results of studies of the lasing characteristics of an organic solid-state tunable laser with a polymethylmethacrylate matrix doped with Chromene 3, Pyrromethene 567, and Pyrromethene 597 dyes. The features of lasing when using selective and nonselective cavities are described. Tuning of the laser wavelength with a spectral linewidth of 0.018 nm in the range 550 – 628 nm is obtained on three polymer laser-active media emitting in the yellow and red spectral regions.
Large-aperture adaptive optical system for correcting wavefront distortions of a petawatt Ti : sapphire laser beam
Authors: Samarkin V.V. , Alexandrov A.G. , Galaktionov I.V. , Kudryashov A.V. , Nikitin A.N. , Rukosuev A.L. , Toporovsky V.V. , Sheldakova Yu.V. 
Published: February 2022

Abstract
This paper reports a large-aperture adaptive optical system with a bimorph deformable mirror and Shack – Hartmann wavefront sensor for aberration correction and beam focusing improvement in state-of-the-art petawatt Ti : sapphire lasers. We consider methods for providing feedback to the wavefront sensor and obtaining an objective wavefront that optimises beam focusing onto a target. The use of an adaptive system with a controlled 127-channel 320-mm-aperture mirror in a Ti : sapphire laser with an output power of 4.2 PW has made it possible to obtain a record high laser beam intensity: 1.1 × 1023 W cm−2.
Electrostatic influence on IL-1 transport through the GSDMD pore
Authors: Xie Wen Jun , Xia Shiyu , Warshel Arieh , Wu Hao 
Published: February 2022

Significance
Gasdermin D (GSDMD) forms large pores that channel the release of alarmins, including interleukin-1 (IL-1) family cytokines, from living cells. IL-1 is synthesized as an inactive cytosolic precursor known as pro-IL-1, which is proteolytically processed into the active mature IL-1 in response to inflammasome activation or other physiological or pathological stimuli. GSDMD pores preferentially release mature IL-1 over pro-IL-1 despite their similar molecular dimensions, both markedly smaller than the pore, indicating that factors beyond size may affect the transport. Our investigation into the role of electrostatics in this preferential release revealed a charge-based gating mechanism for GSDMD pores. Our studies have broad implications in GSDMD-mediated inflammation and contribute to understanding of how large transmembrane pores may achieve cargo preference.
Pluractional perfects in Eonavian Spanish
Authors: Jardón Natalia 
Published: February 2022

Abstract
This chapter deals with two periphrastic constructions that consist of a perfect participle and an inflected form of the verb tener ‘have’ or llevar ‘carry’ in Eonavian Spanish (EoS), which are used to convey perfect meanings and they require a form of iteration or plurality on the event described. These constructions are monoclausal and behave like fully grammaticalized auxiliary constructions, but they are restricted in unexpected ways. The description is complemented by a cross-linguistic comparison of superficially similar constructions in neighbouring Romance varieties. The final part of the chapter considers the extent to which similar constructions in the Galician dialect might explain the properties observed in EoS, concluding that they are independent systems.
Minority language bilingualism and its role in L3 lexical acquisition
Authors: Turrero-García María 
Published: February 2022

Abstract
This chapter focuses on the interplay between working memory, lexical capacity, and (self-rated) proficiency in three groups of speakers: monolingual (Spanish), bilingual (Spanish and English), and trilingual (Spanish, English, and Asturian). There is ample debate on the cognitive and lexical (dis)advantages that bilingualism can grant, and on its impact on third language learning. In this chapter, we argue for a cognitive advantage of any type of bilingualism in accuracy in a Luck and Vogel task, and an advantage of simultaneous bilingualism in reaction times. Additionally, we find no evidence for a disadvantage in lexical retrieval for simultaneous bilinguals.
What is the role of auditory processing in stuttering? A mini review of previous knowledge
Authors: Farazi Morteza , Hosseini Dastgerdi Zahra , Khavarghazalani Bahare 
Published: February 2022

Objectives
Stuttering is one of the most common speech disorders that has a dynamic and multifactorial nature. The evidences suggest that auditory processing deficit may be involved in stuttering. It is not clear how the auditory system relates to stuttering and which aspect of the auditory processing disorder may be the cause of stuttering. This study aimed at presenting a comprehensive review of the literature to better explain the role of the auditory system and auditory processing disorder in stuttering.

Methods
We searched the literature in Elsevier, PubMed, Scopus, and Web of knowledge, Google Scholar databases, Clinical trials, and Cochrane database of systematic reviews from 2000, through 2020. Published studies on the role of the auditory system in stuttering were reviewed.

Results
In articles describing the aetiology of stuttering, auditory processing disorder, particularly temporal processing, has been considered as one of the causes of stuttering. Some researchers considered auditory temporal processing disorder as an intensifying and a sufficient factor for chronic stuttering. According to studies, it seems that auditory temporal processing disorder may affect stuttering by mechanisms such as disturbing the correct auditory feedback to brain speech control centres, instability in neural representations of speech sounds and the occurrence of sensory-motor inconsistencies in the speech control process.

Conclusion
Based on studies, it can be concluded that auditory processing disorder may be one of the underlying or intensifying factors of stuttering.
Unsteady ballistic heat transport in two-dimensional harmonic graphene lattice
Authors: Panchenko A Yu. , Kuzkin V A , Berinskii I E 
Published: February 2022

Abstract
We study the evolution of initial temperature profiles in a two-dimensional isolated harmonic graphene lattice. Two heat transfer problems are solved analytically and numerically. In the first problem, the evolution of a spatially sinusoidal initial temperature profile is considered. This profile is usually generated in real experiments based on the transient thermal grating technique. It is shown that at short times the amplitude of the profile decreases by an order magnitude and then it performs small decaying oscillations. A closed-form solution, describing the decay of the amplitude at short times is derived. It shows that due to symmetry of the lattice, the anisotropy of the ballistic heat transfer is negligible at short times, while at large times it is significant. In the second problem, a uniform spatial distribution of the initial temperature in a circle is specified. The profile is the simplest model of graphene heating by an ultrashort localized laser pulse. The corresponding solution has the symmetry of the lattice and many local maxima. Additionally, we show that each atom has two distinct temperatures corresponding to motions in zigzag and armchair directions. Presented results may serve for proper statement and interpretation of laboratory experiments and molecular dynamics simulations of unsteady heat transfer in graphene.
Thirdkind: displaying phylogenetic encounters beyond 2-level reconciliation
Authors: Penel Simon , Menet Hugo , Tricou Théo , Daubin Vincent , Tannier Eric 
Published: February 2022

Abstract

Motivation
Reconciliation between a host and its symbiont phylogenies or between a species and a gene phylogenies is a prevalent approach in evolution, however no simple generic tool (i.e. virtually usable by all reconciliation software, from host/symbiont to species/gene comparisons) is available to visualize reconciliation results. Moreover there is no tool to visualize 3-levels reconciliations, i.e. to visualize 2 nested reconciliations as for example in a host/symbiont/gene complex.

Results
Thirdkind is a light and easy to install command line software producing svg files displaying reconciliations, including 3-levels reconciliations. It takes a standard format recPhyloXML as input, and is thus usable with most reconciliation software.

Availability and implementation
https://github.com/simonpenel/thirdkind/wiki.

Supplementary information
Supplementary data are available at Bioinformatics online.
The antiepistemology of organized abuse: Ignorance, exploitation, inaction
Authors: Salter Michael , Woodlock Delanie 
Published: February 2022

AbstractOrganized abuse, in which multiple adults sexually abuse multiple children, has an important role to play in the production of child sexual abuse material (CSAM) but has been relegated to the margins of criminological concern. This paper presents the findings of an international survey of 74 adults who described childhood victimization in CSAM and organized abuse, emphasizing the relationship between organized abuse and entrenched ignorance of it. The paper identifies the multiple zones, practices and structures of ignorance that render organized abuse unknowable and advocates for strategic forms of knowledge production in which ignorance features as a provocation towards information-seeking rather than as a defence mechanism against intolerable realities.
Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021
Authors: Perniciaro Stephanie , van der Linden Mark , Weinberger Daniel M 
Published: February 2022

Abstract

Background
The incidence of invasive pneumococcal disease (IPD) decreased worldwide in 2020 and the first quarter of 2021, concurrent with nonpharmaceutical interventions (NPIs) intended to stymie transmission of SARS-CoV-2. In 2021, the stringency of these NPI strategies has varied. We investigated age- and serotype-specific variations in IPD case counts in Germany in 2020–2021.

Methods
IPD cases through 30 November 2021 were stratified by age group, serotype, or geographic location. IPD surveillance data in 2020–2021 were compared with (1) IPD surveillance data from 2015–2019, (2) mobility data during 2020 and 2021, and (3) NPI stringency data in 2020 and 2021.

Results
IPD incidence began to return toward baseline among children 0–4 years old in April 2021 and exceeded baseline by June 2021 (a 9% increase over the average monthly values for 2015–2019). Children aged 5–14 years and adults aged 15–34 or ≥80 years showed increases in IPD cases that exceeded baseline values starting in July 2021, with increases also starting in spring 2021. The age distribution and proportion of vaccine-serotype IPD remained comparable to those in previous years, despite lower overall case counts in 2020 and 2021. The percentage change in IPD incidence compared with the previous 5 years was correlated with changes in mobility and with NPI stringency.

Conclusions
IPD levels began to return to and exceed seasonal levels in spring and summer 2021 in Germany, following sharp declines in 2020 that coincided with NPIs related to the coronavirus disease 2019 pandemic. Proportions of vaccine serotypes remained largely consistent throughout 2020–2021.
Comparative Effectiveness of Coronavirus Disease 2019 (COVID-19) Vaccines Against the Delta Variant
Authors: Risk Malcolm , Shen Chen , Hayek Salim S , Holevinski Lynn , Schiopu Elena , Freed Gary , Akin Cem , Zhao Lili 
Published: February 2022

Abstract

Background
There is a lack of data regarding how the Delta variant of coronavirus disease 2019 (COVID-19) has impacted the effectiveness of the BNT162b2 (Pfizer–BioNTech), mRNA-1273 (Moderna), and Ad26.COV2.S (Johnson & Johnson–Janssen) vaccines at preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 hospitalization.

Methods
We compared the effectiveness of the three vaccines during the pre- and post-Delta variant period (before and after 1 July 2021) in a large cohort of vaccinated and unvaccinated patients in the Michigan Medicine healthcare system. We assessed vaccine effectiveness (VE) using 2 analyses: an inverse propensity weighted (IPW) Kaplan-Meier (KM) analysis based on time from vaccination, and a Cox model based on calendar time with vaccination as a time-varying covariate.

Results
Compared to Ad26.COV2.S recipients, the risk of hospitalization for COVID-19 in the post-Delta variant period was lower for BNT162b2 recipients (hazard ratio [HR] = 0.37; 95% confidence interval [CI]: [.14–.98]; P = .05) and mRNA-1273 recipients (HR = 0.21; 95% CI: [.07–.64]; P = .006). Recipients of the mRNA-1273 vaccine had a lower risk of SARS-CoV-2 infection than Ad26.COV2.S recipients (HR = 0.6; 95% CI: [.43–.83]; P = .003) and BNT162b2 recipients (HR = 0.64; 95% CI: [.54–.76]; P &lt; .001). After 1 July, efficacy against SARS-CoV-2 infection declined for Ad26.COV2.S recipients (VE = 76% before; VE = 49% after; P = .02), BNT162b2 recipients (VE = 87% before; VE = 52% after; P &lt; .001), and mRNA-1273 recipients (VE = 92% before; VE = 70% after; P &lt; .001). Waning immunity and the Delta variant contributed independently and significantly to this decline.

Conclusions
Although there is a substantial decline in effectiveness, the approved COVID-19 vaccines remain effective against infection and hospitalization due to the Delta variant. The mRNA-based vaccines are more effective than the Ad26.COV2.S vaccine.
Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography
Authors: Bouhnik Yoram , Le Berre Catherine , Zappa Magaly , Lewin Maïté , Boudiaf Mourad , Zagdanski Anne Marie , Frampas Eric , Oudjit Ammar , Scotto Béatrice , Tissier Muriel , Annet Laurence , Aufort Sophie , Yzet Thierry , Cuilleron Muriel , Baudin Guillaume , Abitbol Vered , Cosnes Jacques , Bourreille Arnaud , Mary Jean Yves ,   GETAID CDMRIS Study Group, Simon Marion , Dupas Jean Louis , Marteau Philippe , Picon Laurence , Pelletier Anne Laure , Altwegg Romain , Dewit Olivier , Filippi Jérome , Roblin Xavier , Stéfanescu Carmen 
Published: February 2022

Abstract

Background
The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS).

Methods
Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity.

Results
Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild–moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76.

Conclusions
The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps.
BTBD9 attenuates manganese-induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway
Authors: Chen Pan , Cheng Hong , Zheng Fuli , Li Shaojun , Bornhorst Julia , Yang Bobo , Lee Kun He , Ke Tao , Li Yunhui , Schwerdtle Tanja , Yang Xiaobo , Bowman Aaron B , Aschner Michael 
Published: February 2022

Abstract
Manganese (Mn) is an essential mineral, but excess exposure can cause dopaminergic neurotoxicity. Restless legs syndrome (RLS) is a common neurological disorder, but the etiology and pathology remain largely unknown. The purpose of this study was to identify the role of Mn in the regulation of an RLS genetic risk factor BTBD9, characterize the function of BTBD9 in Mn-induced oxidative stress and dopaminergic neuronal dysfunction. We found that human subjects with high blood Mn levels were associated with decreased BTBD9 mRNA levels, when compared with subjects with low blood Mn levels. In A549 cells, Mn exposure decreased BTBD9 protein levels. In Caenorhabditis elegans, loss of hpo-9 (BTBD9 homolog) resulted in more susceptibility to Mn-induced oxidative stress and mitochondrial dysfunction, as well as decreased dopamine levels and alternations of dopaminergic neuronal morphology and behavior. Overexpression of hpo-9 in mutant animals restored these defects and the protection was eliminated by mutation of the forkhead box O (FOXO). In addition, expression of hpo-9 upregulated FOXO protein levels and decreased protein kinase B levels. These results suggest that elevated Mn exposure might be an environmental risk factor for RLS. Furthermore, BTBD9 functions to alleviate Mn-induced oxidative stress and neurotoxicity via regulation of insulin/insulin-like growth factor signaling pathway.