bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cambrian Age 3 small shelly fossils from the Terrades inlier, southern Pyrenees, Spain: Biostratigraphic and paleobiogeographic implications
Authors: Wallet Elise , Padel Maxime , Devaere Léa , Clausen Sébastien , Álvaro J. Javier , Laumonier Bernard 
Published: February 2022

AbstractThe Cambrian stratigraphic succession of the Pyrenees (SW Europe) has undergone a complex Variscan and Alpine tectonothermal history leading to marked metamorphism and development of cleavage networks, which might partly explain the lack of Cambrian fossiliferous beds. This gap has traditionally precluded its paleobiogeographic and biostratigraphic relationships with other neighboring peri-Gondwanan units. Correlations are only based on lithostratigraphic comparisons and radiometric constraints. In this general scheme, the Terrades inlier (Gerona Province, Spain) provides the only significant and indisputable ‘early Cambrian’ fossil record of the Pyrenees. This predominantly siliciclastic outcrop consists of multiple patch reefs and bioherms having yielded archeocyaths dated at Cambrian Epoch 2, Age 3. This paper describes, for the first time, the microfossil assemblage included in the archeocyathan-microbial reefal complex that crops out in the Terrades inlier to clarify its age and affinities with surrounding tectonostratigraphic units. Reefal flanks of patch reefs have yielded bradoriids, brachiopods, molluscs, tommotiids, chancelloriids, hyoliths, and the problematic fossil (and chronostratigraphically significant)Rhombocorniculum cancellatumCobbold, 1921. In addition to confirming the previously assigned age of the succession, the recovered fauna emphasizes strong affinities with the surrounding Occitan Domain (Montagne Noire, southern Massif Central, France) and Sardinia (Italy). Along with lithostratigraphic comparison and tectonic considerations, this further supports the recent reconstructions positioning the Pyrenean domain between the Montagne Noire (to the southwest) and Sardinia (further to the northeast) on the Gondwana margin during Cambrian times.
Colloidal stability of milk: reinterpretation of alcohol test results by digital microscopy
Authors: da Costa Cláudio Humberto Ferreira , de Paula Igor Lima , da Silva Paulo Henrique Fonseca , Perrone Ítalo Tuler , Stephani Rodrigo , Cappa de Oliveira Luiz Fernando 
Published: February 2022

AbstractIn this research communication we propose a new approach by portable digital microscopy with a 200× objective to improve the visualization of microparticles of pasteurized milk submitted to the alcohol test. Not only did the method reduce the subjectivity of the readings, but also generated high resolution images of the microparticles, which allows the creation of a specific image pattern for each type of final product. In comparison to a control pasteurized milk treatment, the results confirmed the effect and the specificity of added salts (sodium citrate, disodium phosphate or their combination) on the stability of the milk to the alcohol test. Finally, the mixture of stabilizing salts of citrate/phosphate provided the highest degree of stability to pasteurized milk among the treatments studied.
Addressing historical trauma and healing in Indigenous language cultivation and revitalization
Authors: McKenzie James 
Published: February 2022

AbstractThis paper demonstrates that historical trauma, healing, and wellbeing require attention in Indigenous language cultivation and revitalization. While historical trauma affects Indigenous peoples across the spectrum of language knowledge and use, little is written about the ways it can be addressed in the teaching, learning, and development—the cultivation—of Indigenous languages. For Indigenous language educators, how we address historical trauma in our language cultivation may be one of the most critical factors affecting our potential to cultivate the wellness we seek, and new generations of speakers of our languages. Drawing on a Diné (Navajo) lens and voices from other Indigenous communities, this article focuses on historical trauma, healing, and wellbeing as important considerations in Indigenous language cultivation and revitalization, to which applied linguists, Indigenous peoples, and others interested in Indigenous language revitalization and Indigenous wellbeing should pay attention. It argues that many of the most appropriate approaches can and will come from within our own Indigenous ways of knowing and healing, and that sharing more work of this kind can strengthen cultivation and revitalization efforts. It provides recommendations for applied linguistics and allied fields, educational, governmental and other resource holders, and Indigenous communities, programs, language cultivators and revitalizers.
Faecal carriage of Clostridioides difficile is low among veterinary healthcare workers in the Netherlands
Authors: Meijs Anouk P. , Gijsbers Esther F. , Hengeveld Paul D. , Kuijper Ed J. , Dierikx Cindy M. , de Greeff Sabine C. , van Duijkeren Engeline 
Published: February 2022

Abstract
Veterinary healthcare workers are in close contact with many different animals and might be at an increased risk of acquiring Clostridioides difficile. In this cross-sectional study, we assessed the prevalence and risk factors of C. difficile carriage in Dutch veterinary healthcare workers. Participants provided a faecal sample and filled out a questionnaire covering potential risk factors for C. difficile carriage. C. difficile culture positive isolates were polymerase chain reaction (PCR) ribotyped and the presence of toxin genes tcdA, tcdB and cdtA/cdtB was determined. Eleven of 482 [2.3%; 95% confidence interval (CI) 1.3–4.0] veterinary healthcare workers were carriers of C. difficile. Three persons carried C. difficile ribotype 078 (0.6%; 95% CI 0.2–1.8). Risk factors for carriage were health/medication and hygiene related, including poor hand hygiene after patient (animal) contact, and did not include occupational contact with certain animal species. In conclusion, the prevalence of C. difficile carriage in veterinary healthcare workers was low and no indications were found that working in veterinary care is a risk for C. difficile carriage.
Impact of right anterolateral thoracotomy with a new approach on breast development: survey analysis of female cardiac surgery patients
Authors: Turkcan Başak Soran , Atalay Atakan , Kulahcioglu Emre , Tasoglu Irfan 
Published: February 2022

AbstractIntroduction:Our aim was to present the effects of submammarian thoracotomy by our new approach to breast development in young female patients between 8 and 14 years old.Methods:Atrial septal defect closure was performed in 55 female patients between 8 and 14 years old at the time of operation between January 2010 and January 2018 by median sternotomy or right anterolateral thoracotomy. These patients were called for a follow-up visits, breast examination were performed, and a questionnaire of 10 questions was applied.Results:According to the answer given by the patients to the question of “how would you describe your scar” showed that the surgical method satisfies all patients cosmetically in study group. The overall satisfaction rate for the cosmetic results of operation was 100% versus 41.1%, respectively. The percentage of patients said no to the question “Do you experience lack of self-confidence related your scar” was significantly higher than the control group (p < 0.001). The percentage of those who said yes to the question “Would you like to be operated with the same approach if you will have surgery again?” in the study group was significantly higher than the control group (p = 0.002).Conclusions:We consider that our procedure is safe and effective with improved cosmetic results compared to median sternotomy which also confers many advantages such as less trauma, less pain, faster recovery, and shorter hospital stay. This study presents one of the largest series of paediatric patients operated by submammarian thoracotomy.
Explainable lexical entailment with semantic graphs
Authors: Kovacs Adam , Gemes Kinga , Kornai Andras , Recski Gabor 
Published: February 2022

AbstractWe present novel methods for detecting lexical entailment in a fully rule-based and explainable fashion, by automatic construction of semantic graphs, in any language for which a crowd-sourced dictionary with sufficient coverage and a dependency parser of sufficient accuracy are available. We experiment and evaluate on both the Semeval-2020 lexical entailment task (Glavaš et al. (2020). Proceedings of the Fourteenth Workshop on Semantic Evaluation, pp. 24–35) and the SherLIiC lexical inference dataset of typed predicates (Schmitt and Schütze (2019). Proceedings of the 57th Annual Meeting of the Association for Computational Linguistics, pp. 902–914). Combined with top-performing systems, our method achieves improvements over the previous state-of-the-art on both benchmarks. As a standalone system, it offers a fully interpretable model of lexical entailment that makes detailed error analysis possible, uncovering future directions for improving both the semantic parsing method and the inference process on semantic graphs. We release all components of our system as open source software.
Additive and synergistic interactions of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and photosystem II (PSII) inhibitors for the control of glyphosate-resistant horseweed (Conyza canadensis) in corn
Authors: Fluttert John C. , Soltani Nader , Galla Mariano , Hooker David C. , Robinson Darren E. , Sikkema Peter H. 
Published: February 2022

AbstractGlyphosate-resistant (GR) horseweed [Conyza canadensis (L.) Cronquist; syn.: Erigeron canadensis L.] interference can substantially reduce corn (Zea mays L.) yield. The complementary activity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and photosystem II (PSII) inhibitors has been investigated for the control of several weed species, and in many cases has been synergistic; however, there is little information on the interaction of HPPD- and PSII-inhibiting herbicides for postemergence control of GR C. canadensis in corn. Four field trials were studied over 2 yr (2019, 2020) in Ontario, Canada, in commercial corn fields with natural infestations of GR C. canadensis to evaluate the level of GR C. canadensis control with three HPPD-inhibiting herbicides (mesotrione, tolpyralate, and topramezone) and three PSII-inhibiting herbicides (atrazine, bromoxynil, and bentazon) applied individually and in tank-mix combinations, and to document the interaction of the three HPPD inhibitors tank mixed with the three PSII inhibitors. Mesotrione, tolpyralate, and topramezone controlled GR C. canadensis 83%, 84%, and 72%, respectively, at 8 wk after application (WAA). Bromoxynil and bentazon controlled GR C. canadensis 71% and 79%, respectively, while atrazine provided only 31% control at 8 WAA. The joint application of atrazine, bromoxynil, or bentazon with mesotrione increased GR C. canadensis control from 83% to 100% at 8 WAA. Tolpyralate tank mixed with atrazine, bromoxynil, or bentazon controlled GR C. canadensis 96%, 98%, and 98%, respectively, which was comparable to the mesotrione tank mixes at 8 WAA. Topramezone plus atrazine, bromoxynil, or bentazon controlled GR C. canadensis 91%, 93%, and 95%, respectively, at 8 WAA. Interactions between HPPD and PSII inhibitors were synergistic for all combinations of mesotrione or tolpyralate with atrazine, bromoxynil, or bentazon. The interaction between topramezone and PSII inhibitors was additive. All nine tank mixes controlled GR C. canadensis >90%. This study concludes that bromoxynil or bentazon, instead of atrazine, can be co-applied with mesotrione, tolpyralate, or topramezone without compromising GR C. canadensis control in corn.
Spatial Analysis and Lead‐Risk Assessment of Philadelphia, USA
Authors: Caballero‐Gómez H. , White H. K. , O’Shea M. J. , Pepino R. , Howarth M. , Gieré R. 
Published: February 2022

AbstractChildhood lead poisoning is an issue that continues to plague major U.S. cities. Despite efforts by the Philadelphia Department of Public Health to curtail systemic childhood lead poisoning, children continue to be identified with elevated blood lead levels. The persistence of elevated blood lead levels in children is concerning because lead poisoning has been linked to decreases in academic achievement and IQ, with associated repercussions for entire communities. This paper reports the results of an analysis of the spatial distribution of houses with lead paint (i.e., pre‐1978), demolitions, and occurrence of historic smelters, in West and North Philadelphia, relative to elevated blood lead level data, to determine which lead sources act as primary lead‐risk factors. The presence of lead paint in homes and the number of demolitions of older properties were found to have the highest correlations to elevated blood lead levels for children in Philadelphia. Using lead‐risk factors including lead paint, housing code violations, demolitions, and owner‐occupied housing units, a lead‐risk assessment was performed at the census tract level to identify future soil sampling sites and high‐risk neighborhoods in Philadelphia. These sites of high risk for lead exposure, and in particular the census tracts 175 and 172, should be prioritized for lead poisoning prevention initiatives.
Persistent Ross Sea Freshening From Imbalance West Antarctic Ice Shelf Melting
Authors: Jacobs S. S. , Giulivi C. F. , Dutrieux P. 
Published: February 2022

AbstractA 63‐year observational record in the southwest Ross Sea shows a continuing, near‐linear salinity decrease of 0.170 and slight warming of 0.013°C through 2020. That freshening exceeded any increase in sea ice production and brine release from stronger southerly winds, while melting and freezing at the Ross Ice Shelf base contributed little to the salinity change. The parallel seawater density decline appears not to have enhanced warm deep water intrusions onto the continental shelf (CS). Confirming prior inferences, the salinity change has been mainly caused by a growing imbalance in the meltwater available from thinning ice shelves and increased iceberg calving in the upstream Amundsen and Bellingshausen Seas. Shorter‐term salinity variability has tracked winds near the Amundsen Sea CS break, in turn coherent with a broader Pacific climate variability index, and with salinity reversals on and seaward of the Ross CS. The melt driven freshening is positively correlated with global atmospheric CO2 and temperature increases, and adds to the rise in sea level from increased glacier flow into weakened ice shelves. Continued erosion of those ice shelves could end the production of high salinity shelf and bottom waters, as defined in the Ross Sea, by the 2050s.
Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Authors: Dizman Nazli , Meza Luis , Bergerot Paulo , Alcantara Marice , Dorff Tanya , Lyou Yung , Frankel Paul , Cui Yujie , Mira Valerie , Llamas Marian , Hsu Joann , Zengin Zeynep , Salgia Nicholas , Salgia Sabrina , Malhotra Jasnoor , Chawla Neal , Chehrazi-Raffle Alex , Muddasani Ramya , Gillece John , Reining Lauren , Trent Jeff , Takahashi Motomichi , Oka Kentaro , Higashi Seiya , Kortylewski Marcin , Highlander Sarah K. , Pal Sumanta K. 
Published: February 2022

AbstractPrevious studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could augment CPI response through modulation of the gut microbiome. In this open-label, single-center study (NCT03829111), 30 treatment-naive patients with metastatic renal cell carcinoma with clear cell and/or sarcomatoid histology and intermediate- or poor-risk disease were randomized 2:1 to receive nivolumab and ipilimumab with or without daily oral CBM588, respectively. Stool metagenomic sequencing was performed at multiple timepoints. The primary endpoint to compare the relative abundance of Bifidobacterium spp. at baseline and at 12 weeks was not met, and no significant differences in Bifidobacterium spp. or Shannon index associated with the addition of CBM588 to nivolumab–ipilimumab were detected. Secondary endpoints included response rate, progression-free survival (PFS) and toxicity. PFS was significantly longer in patients receiving nivolumab–ipilimumab with CBM588 than without (12.7 months versus 2.5 months, hazard ratio 0.15, 95% confidence interval 0.05–0.47, P = 0.001). Although not statistically significant, the response rate was also higher in patients receiving CBM588 (58% versus 20%, P = 0.06). No significant difference in toxicity was observed between the study arms. The data suggest that CBM588 appears to enhance the clinical outcome in patients with metastatic renal cell carcinoma treated with nivolumab–ipilimumab. Larger studies are warranted to confirm this clinical observation and elucidate the mechanism of action and the effects on microbiome and immune compartments.
Functional analysis of the airways after pulmonary lobectomy through computational fluid dynamics
Authors: Aliboni Lorenzo , Tullio Marta , Pennati Francesca , Lomauro Antonella , Carrinola Rosaria , Carrafiello Gianpaolo , Nosotti Mario , Palleschi Alessandro , Aliverti Andrea 
Published: February 2022

AbstractPulmonary lobectomy, which consists of the partial or complete resection of a lung lobe, is the gold standard intervention for lung cancer removal. The removal of functional tissue during the surgery and the re-adaptation of the remaining thoracic structures decrease the patient's post-operative pulmonary function. Residual functionality is evaluated through pulmonary function tests, which account for the number of resected segments without considering local structural alterations and provide an average at-the-mouth estimation. Computational Fluid Dynamics (CFD) has been demonstrated to provide patient-specific, quantitative, and local information about airways airflow dynamics. A CFD investigation was performed on image-based airway trees reconstructed before and after the surgery for twelve patients who underwent lobectomy at different lobes. The geometrical alterations and the variations in fluid dynamics parameters and in lobar ventilation between the pre and post-operative conditions were evaluated. The post-operative function was estimated and compared with current clinical algorithms and with actual clinical data. The post-operative configuration revealed a high intersubject variability: regardless of the lobectomy site, an increment of global velocity, wall pressure, and wall shear stress was observed. Local flow disturbances also emerged at, and downstream of, the resection site. The analysis of lobar ventilation showed severe variations in the volume flow rate distribution, highlighting the compensatory effects in the contralateral lung with an increment of inflow. The estimation of post-operative function through CFD was comparable with the current clinical algorithm and the actual spirometric measurements. The results confirmed that CFD could provide additional information to support the current clinical approaches both in the operability assessment and in the prescription of personalized respiratory rehabilitation.
Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual
Authors: Vraka Chrysoula , Murgaš Matej , Rischka Lucas , Geist Barbara Katharina , Lanzenberger Rupert , Gryglewski Gregor , Zenz Thomas , Wadsak Wolfgang , Mitterhauser Markus , Hacker Marcus , Philippe Cécile , Pichler Verena 
Published: February 2022

AbstractSimultaneous characterization of pathologies by multi-tracer positron emission tomography (PET) is among the most promising applications in nuclear medicine. Aim of this work was the simultaneous production of two PET-tracers in one module and test the relevance for human application. [11C]harmine and [11C]DASB were concurrently synthesized in a ‘two-in-one-pot’ reaction in quality for application. Dual-tracer protocol was simulated using 16 single PET scans in different orders of tracer application separated by different time intervals. Volume of distribution was calculated for single- and dual-tracer measurements using Logan’s plot and arterial input function in 13 brain regions. The ‘two-in-one-pot’ reaction yielded equivalent amounts of both radiotracers with comparable molar activities. The simulations of the dual-tracer application were comparable to the single bolus injections in 13 brain regions, when [11C]harmine was applied first and [11C]DASB second, with an injection time interval of 45 min (rxy = 0.90). Our study shows the successful simultaneous dual-tracer production leading to decreased radiation burden and costs. The simulation of dual subject injection to quantify the monoamine oxidase-A and serotonin transporter distribution proved its high potential. Multi-tracer imaging may drive more sophisticated study designs and diminish the day-to-day differences in the same individual as well as increase PET scanner efficiency.
A COVID-19 mortality prediction model for Korean patients using nationwide Korean disease control and prevention agency database
Authors: Jee Yongho , Kim Yi-Jun , Oh Jongmin , Kim Young-Ju , Ha Eun-Hee , Jo Inho 
Published: February 2022

AbstractThe experience of the early nationwide COVID-19 pandemic in South Korea led to an early shortage of medical resources. For efficient resource allocation, accurate prediction of the prognosis or mortality of confirmed patients is essential. Therefore, the aim of this study was to develop an accurate model for predicting COVID-19 mortality using epidemiolocal and clinical variables and for identifying a high-risk group of confirmed patients. Clinical and epidemiolocal variables of 4049 patients with confirmed COVID-19 between January 20, 2020 and April 30, 2020 collected by the Korean Disease Control and Prevention Agency were used. Among the 4049 total confirmed patients, 223 patients died, while 3826 patients were released from isolation. Patients who had the following risk factors showed significantly higher risk scores: age over 60 years, male sex, difficulty breathing, diabetes, cancer, dementia, change of consciousness, and hospitalization in the intensive care unit. High accuracy was shown for both the development set (n = 2467) and the validation set (n = 1582), with AUCs of 0.96 and 0.97, respectively. The prediction model developed in this study based on clinical features and epidemiological factors could be used for screening high-risk groups of patients and for evidence-based allocation of medical resources.