bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring Komputer Client Dengan Remote Destop (Studi Kasus Laboratorium Komputer STMIK AMIK Riau)
Authors: - Dwi Haryono 
Published: October 2022

Laboratorium komputer adalah tempat riset ilmiah, eksperimen, pengukuran ataupun pelatihan ilmiah yang berhubungan dengan ilmu komputer dan memiliki beberapa komputer dalam satu jaringan untuk penggunaan oleh kalangan tertentu.Â Penggunaan laboratorium komputer di STMIK-AMIK Riau sendiri lebih ke arah proses pembelajaran dan pengukuran dari kemampuan mahasiswa dalam pemakaian komputer itu sendiri. Di dalam Loboratorium komputer yang terjadi mahasiswa pasti akan mengalami kesulitan dan memerlukan bantuan Monitoring sehingga dosen/asissten harus berkeliling dalam membantu mahasiswa untuk memecahkan permasalahan yang terjadi, selain itu banyaknya jumlah mahasiswa membuat Monitoring tidak dapat mengawasi secara keseluruhan mahasiswa saat ujian berlangsung. Remote desktop bisa menjadi jawaban atas permasalahan tersebut dimana remote desktop mengizinkan penggunanya untuk terkoneksi ke sebuah komputer jarak jauh seolah-olah mereka duduk di depan mesin yang bersangkutan. Selain itu sistem yang akan dibentuk dapat juga mengawasi pengunaan program yang digunakan oleh mahasiswa. Diharapkan sistem yang akan dibentuk nantinya dapat meminimalisir kecurangan yang terjadi saat proses ujian berlangsung seperti bertukar data dan bisa meningkatkan efektivitas dari proses belajar mengajar yang terjadi di laboratorium komputer
Penerapan Interpolasi Lanjar Terhadap Piksel Gambar Digital yang Diperbesar
Authors: - Koko Harianto 
Published: October 2022

Gambar merupakan representasi atau imitasi dari suatu objek. Proses pengolahan gambar merupakan proses yang dilakukan untuk menggali informasi yang terdapat di dalam gambar. Salah satu pengolahan gambar adalah dengan membesarkan ukuran gambar (zoom in). Proses pembesaran gambar dilakukan dengan menyisipkan sejumlah piksel diantara dua piksel Â pada suatu gambar, namun proses penambahan piksel tersebut akan menimbulkan suatu permasalahan yaitu berapakah harga untuk masing-masing piksel baru tersebut agar gambar tidak mengalami kerusakan atau kehilangan informasi . Dalam metode numerik, apabila ingin menemukan nilai diantara dua buah nilai yang sudah didefinisikan, maka dapat menggunakan teknik interpolasi lanjar. Interpolasi lanjar merupakan teknik untuk memberikan nilai hampiran diantara dua nilai yang diinterpolasi dengan menggunakan garis lurus. Dengan menerapkan interpolasi lanjar, maka akan Â menentukan harga atau nilai yang akan menempati masing-masing piksel baru yang ditambahkan pada saat pembesaran gambar
Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model
Authors: Gao Yang , Chen Haoyuan , Cang Xueyu , Chen Hongliang , Di Yuzhu , Qi Jihan , Cai Huimin , Luo Kunpeng , Jin Shizhu 
Published: October 2022

Background: Small intestinal ischemia-reperfusion (IR) injury is a common intestinal disease with high morbidity and mortality. Mesenchymal stem cells (MSCs) have been increasingly used in various intestinal diseases. This study aimed to evaluate the therapeutic effect of hair follicle MSCs (HFMSCs) on small intestinal IR injury.Methods: We divided Sprague–Dawley rats into three groups: the sham group, IR group and IR + HFMSCs group. A small intestinal IR injury rat model was established by clamping of the superior mesenteric artery (SMA) for 30 min and reperfusion for 2 h. HFMSCs were cultured in vitro and injected into the rats through the tail vein. Seven days after treatment, the intrinsic homing and differentiation characteristics of the HFMSCs were observed by immunofluorescence and immunohistochemical staining, and the paracrine mechanism of HFMSCs was assessed by Western blotting and enzyme-linked immunosorbent assay (ELISA).Results: A small intestinal IR injury model was successfully established. HFMSCs could home to damaged sites, express proliferating cell nuclear antigen (PCNA) and intestinal stem cell (ISC) markers, and promote small intestinal ISC marker expression. The expression levels of angiopoietin-1 (ANG1), vascular endothelial growth factor (VEGF) and insulin growth factor-1 (IGF1) in the IR + HFMSCs group were higher than those in the IR group. HFMSCs could prevent IR-induced apoptosis by increasing B-cell lymphoma-2 (Bcl-2) expression and decreasing Bcl-2 homologous antagonist/killer (Bax) expression. Oxidative stress level detection showed that the malondialdehyde (MDA) content was decreased, while the superoxide dismutase (SOD) content was increased in the IR + HFMSCs group compared to the IR group. An elevated diamine oxidase (DAO) level reflected the potential protective effect of HFMSCs on the intestinal mucosal barrier.Conclusion: HFMSCs are beneficial to alleviate small intestinal IR injury through intrinsic homing to the small intestine and by differentiating into ISCs, via a paracrine mechanism to promote angiogenesis, reduce apoptosis, regulate the oxidative stress response, and protect intestinal mucosal function potentially. Therefore, this study suggests that HFMSCs serve as a new option for the treatment of small intestinal IR injury.
Microstructure and properties analysis of the brazing alloy prepared from recycled E-waste
Authors: Yang Jiao , Bao Li , Long Weimin , Zhong Sujuan , Qin Jian , Qiao Ruilin 
Published: October 2022

In order to realize the efficient and comprehensive utilization of e-waste resources and short process preparation of alloy brazing materials, this study has analyzed the microstructure and properties of e-waste recycled brazing alloys by the analysis methods of inductively coupled plasma emission spectrometer, differential scanning calorimeter, scanning electron microscope, metalloscope, X-ray diffractometer, micro-hardness tester. Experimental results showed that phase compositions are significant differences between the alloys prepared by the recycled e-waste and the pure metals. The circuit board recycling alloy mainly consisted of α-Fe dendrites, (Cu, Sn) phases, Sn-rich phases and Cu matrix, while the alloy obtained by pure metals is composed of (Cu, Sn) phase, Sn-rich phase and Cu matrix. The melting temperature of alloy obtained by melting the circuit board is in the range of 985.3°C–1,053.0°C, which was wider and higher than that of alloy obtained by pure metal smelting. The shear strengths of the joints brazed by the brazing alloys prepared by the recycle e-waste and pure metals are 182.21 MPa and 277.02 MPa, respectively. There is little difference in hardness between the two types of brazed joints. In addition, there are a large number of precipitated phases in alloy obtained by the recycled circuit board, owing to the precipitation strengthening mechanism. The main strengthening mechanism of alloy obtained by pure metals is solid-solution strengthening. The paper focused primarily on alloy obtained by melting the circuit board and studying the specific composition, melting temperature, structure, and properties of alloys formed by melting the circuit board and pure metals. Meawhile, the size, morphology and other microstructure evolution of the second phase of brazing alloy were investigated to provide theoretical guidance for the brazing alloy in the subsequent actual production process.
Investigation of thrombin generation assay to predict vaso-occlusive crisis in adulthood with sickle cell disease
Authors: Feugray Guillaume , Kasonga Fiston , Grall Maximilien , Dumesnil Cécile , Benhamou Ygal , Brunel Valery , Le Cam Duchez Véronique , Lahary Agnès , Billoir Paul 
Published: October 2022

IntroductionSickle cell disease (SCD) is an inherited hemoglobinopathy disorder. The main consequence is synthesis of hemoglobin S leading to chronic hemolysis associated with morbidity. The aim of this study was to investigate Thrombin Generation Assay (TGA) to assess hypercoagulability in SCD and TGA parameters as biomarkers of vaso-occlusive crisis (VOC) risk and hospitalization within 1 year.Materials and methodsWe performed TGA in platelet poor plasma (PPP) with 1 pM of tissue factor and 4 μM of phospholipid-standardized concentration, in duplicate for patients and controls. We measured thrombomodulin (TM), soluble endothelial Protein C Receptor and Tissue Factor Pathway Inhibitor (TFPI).ResultsA total of 113 adult patients with SCD, 83 at steady state and 30 during VOC, and 25 healthy controls matched on age and gender were included. Among the 83 patients at steady state, (36 S/S-1 S/β0, 20 S/Sα3.7, and 19 S/C-7 S/β+) 28 developed a VOC within 1 year (median: 4 months [2.25–6]). We observed an increase of peak and velocity associated with a shortening of lagtime and time to peak (TTP) and no difference of endogenous thrombin potential (ETP) in patients compared to controls. TFPI (p &lt; 0.001) and TM (p = 0.006) were significantly decreased. TGA confirmed hypercoagulability in all SCD genotypes and clinical status. The association of ETP &gt; 1,207 nM.min and peak &gt;228.5 nM presented a sensitivity of 73.5% and a specificity of 93.9% to predict VOC development within 1 year.ConclusionWe have demonstrated a hypercoagulable state in SCD associated with chronic hemolysis. These preliminary findings suggest that TGA parameters, as ETP and peak, could be used to predict VOC development within 1 year.
Electrocardiogram abnormalities and prognosis in COVID-19
Authors: Chevrot Gabriel , Hauguel-Moreau Marie , Pépin Marion , Vieillard-Baron Antoine , Lot Anne-Sophie , Ouadahi Mounir , Hergault Hélène , Aïdan Vincent , Greffe Ségolène , Costantini Adrien , Dubourg Olivier , Beaune Sébastien , Mansencal Nicolas 
Published: October 2022

BackgroundCOVID-19 is a major pandemic with potential cardiovascular complications. Few studies have focused on electrocardiogram (ECG) modifications in COVID-19 patients.Method and resultsWe reviewed from our database all patients referred to our hospital for COVID-19 between January 1st, 2020, and December 31st, 2020: 669 patients were included and 98 patients died from COVID-19 (14.6%). We systematically analyzed ECG at admission and during hospitalization if available. ECG was abnormal at admission in 478 patients (71.4%) and was more frequently abnormal in patients who did not survive (88.8 vs. 68.5%, p &lt; 0.001). The most common ECG abnormalities associated with death were left anterior fascicular block (39.8 vs. 20.0% among alive patients, p &lt; 0.001), left and right bundle branch blocks (p = 0.002 and p = 0.02, respectively), S1Q3 pattern (14.3 vs. 6.0%, p = 0.006). In multivariate analysis, at admission, the presence of left bundle branch block remained statistically related to death [OR = 3.82, 95% confidence interval (CI): 1.52–9.28, p &lt; 0.01], as well as S1Q3 pattern (OR = 3.17, 95% CI: 1.38–7.03, p &lt; 0.01) and repolarization abnormalities (OR = 2.41, 95% CI: 1.40–4.14, p &lt; 0.01).On ECG performed during hospitalization, the occurrence of new repolarization abnormality was significantly related to death (OR = 2.72, 95% CI: 1.14–6.54, p = 0.02), as well as a new S1Q3 pattern (OR = 13.23, 95% CI: 1.49–286.56, p = 0.03) and new supraventricular arrhythmia (OR = 3.8, 95% CI: 1.11–13.35, p = 0.03).ConclusionThe presence of abnormal ECG during COVID-19 is frequent. Physicians should be aware of the usefulness of ECG for risk stratification during COVID-19.
Effects of perioperative glycemic indicators on outcomes of endovascular treatment for vertebrobasilar artery occlusion
Authors: Gu Mengmeng , Fan Jin , Xu Pengfei , Xiao Lulu , Wang Jinjing , Li Min , Liu Chaolai , Luo Genpei , Cai Qiankun , Liu Dezhi , Ye Lichao , Zhou Junshan , Sun Wen 
Published: October 2022

ObjectiveEndovascular treatment (EVT) is, to date, the most promising treatment of vertebrobasilar artery occlusion (VBAO). The study aimed to determine the influence of perioperative glucose levels on clinical outcomes in patients with acute VBAO treated with EVT.MethodsWe retrospectively collected consecutive VBAO patients received EVT in 21 stroke centers in China. The associations between perioperative glycemic indicators (including fasting blood glucose[FBG], admission hyperglycemia, stress hyperglycemia ratio [SHR] and short-term glycemic variability [GV]) and various clinical outcomes were analyzed in all patients and subgroups stratified by diabetes mellitus (DM).ResultsA total of 569 patients were enrolled. Admission hyperglycemia significantly correlated with increased risk of symptomatic intracranial hemorrhage (sICH) (odds ratio [OR] 3.24, 95% confidence interval [CI]: 1.40-7.46), poor functional outcomes at 90 days (OR 1.91, 95%CI: 1.15-3.18) and 1 year (OR 1.96, 95%CI: 1.20-3.22). Similar significant correlations exist between FBG, SHR, GV and all the adverse outcomes except higher levels GV was not associated with increased risk of sICH (OR 1.04, 95% CI: 0.97-1.12). Subgroup analyses showed that admission hyperglycemia, FBG and SHR were significantly associated with adverse outcomes in non-diabetic patients, but not in DM patients. While, GV was associated with poor functional outcomes regardless of diabetes history.ConclusionsAdmission hyperglycemia, FBG, SHR and short-term GV in VBAO patients treated with EVT were associated with adverse outcomes. The results suggested that comprehensive evaluation and appropriate management of perioperative glucose might be important for patients with VBAO and treatment with EVT.
Metformin and risk of gingival/periodontal diseases in diabetes patients: A retrospective cohort study
Authors: Tseng Chin-Hsiao 
Published: October 2022

AimTo compare the risk of gingival and periodontal diseases (GPD) between ever users and never users of metformin in patients with type 2 diabetes mellitus.MethodsThe Taiwan’s National Health Insurance database was used to enroll 423,949 patients with new onset diabetes mellitus from 1999 to 2005. After excluding ineligible patients, 60,309 ever users and 5578 never users were followed up for the incidence of GPD from January 1, 2006 until December 31, 2011. Propensity score-weighted hazard ratios were estimated by Cox regression.ResultsGPD was newly diagnosed in 18,528 ever users (incidence: 7746.51 per 100,000 person-years) and 2283 never users (incidence: 12158.59 per 100,000 person-years). The hazard ratio that compared ever users to never users was 0.627 (95% confidence interval: 0.600-0.655). When metformin use was categorized by tertiles of cumulative duration and cumulative dose, the risk significantly reduced in a dose-response pattern when the cumulative duration reached approximately 2 years or the cumulative dose reached 670 grams. Analyses on the tertiles of defined daily dose of metformin showed that the reduction of GPD risk could be seen in all three subgroups but the benefit would be greater when the daily dose increased.ConclusionLong-term use of metformin is associated with a significantly reduced risk of GPD.
Association between perfluoroalkyl substances concentration and bone mineral density in the US adolescents aged 12-19 years in NHANES 2005-2010
Authors: Xiong Xianmei , Chen Baihang , Wang Zhongqing , Ma Liqiong , Li Shijie , Gao Yijia 
Published: October 2022

BackgroundReports on the association of perfluoroalkyl substances (PFASs) exposure with adolescent bone health are scarce, and studies have primarily targeted maternal serum.ObjectiveWe evaluated the relationship between autologous serum perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) levels and bone mineral density (BMD) in adolescents.MethodsWe analyzed data from 1228 adolescents aged 12-19 years in the National Health and Nutrition Examination Survey (NHANES) 2005-2010 and used multiple regression analysis to identify the relationship between serum PFOA, PFOS, PFHxS, and PFNA concentrations and total femur, femoral neck, and lumbar spine BMD, in addition to multiple stratified subgroup analyses.ResultsThe mean age of participants was 15 years, males had higher serum PFAS concentrations than females. The results of multiple regression analysis showed that the natural log(ln)-transformed serum PFOA, PFOS, and PFNA concentrations were negatively correlated with total femur, femoral neck, and lumbar spine BMD (all p &lt; 0.05), and ln-PFHxS was positively correlated with total femur and femoral neck BMD (all p&lt; 0.05). In males, ln-PFOA was negatively associated with total femur and lumbar spine BMD (all p&lt; 0.05), ln-PFOS was associated with the reduced total femur, femoral neck, and lumbar spine BMD (all p&lt; 0.05), while ln-PFHxS and ln-PFNA were not observed to correlate with BMD at these three sites. In females, both ln-PFOA and ln-PFOS were negatively correlated with total femur and lumbar spine BMD (all p&lt; 0.05), ln-PFHxS is associated with the increased total femur and femoral neck BMD (all p&lt; 0.05), and ln-PFNA was negatively correlated with total femur and femoral neck BMD (all p&lt; 0.05), most of the associations were confined to females. The associations of ln-PFOS with femoral neck BMD and ln-PFNA with total femur BMD were more significant in those who were overweight/obese and had anemia, respectively (all p for interaction &lt; 0.05).ConclusionsIn this representative sample of US adolescents aged 12-19 years, certain PFAS were associated with lower bone mineral density, and most of the associations were confined to females. The negative effect of PFAS on BMD is more pronounced in those who are overweight/obese and have anemia. However, further studies are needed to confirm this finding.
Curve matching to predict growth in patients receiving growth hormone therapy: An interpretable & explainable method
Authors: van Dommelen Paula , Arnaud Lilian , Koledova Ekaterina 
Published: October 2022

Curve matching may be used to predict growth outcomes using data of patients whose growth curves resemble those of a new patient with growth hormone deficiency (GHD) and those born small for gestational age (SGA). We aimed to investigate the validity of curve matching to predict growth in patients with GHD and those born SGA receiving recombinant human growth hormone (r-hGH). Height data collected between 0–48 months of treatment were extracted from the easypod™ connect ecosystem and the easypod™ connect observational study. Selected patients with height standard deviation scores (HSDS) [-4, &lt;-1] and age [3, &lt;16y] at start were included. The ‘Matching Database’ consisted of patients’ monthly HSDS obtained by the broken stick method and imputation. Standard deviation (SD) was obtained from the observed minus the predicted HSDS (error) based on matched patients within the ‘Matching Database’. Data were available for 3,213 patients in the ‘Matching Database’, and 2,472 patients with 16,624 HSDS measurements in the observed database. When ≥2 HSDS measurements were available, the error SD for a one-year prediction was approximately 0.2, which corresponds to 1.1 cm, 1.3 cm, and 1.5 cm at 7, 11, and 15 years of age, respectively. Indication and age at treatment start (&lt;11 vs ≥11 years) had a small impact on the error SD, with patients born SGA and patients aged &lt;11 years at treatment start generally having slightly lower values. We conclude that curve matching is a simple and valid technique for predicting growth in patients with GHD and those born SGA.
Hearing loss and risk of depressive symptoms in older adults in the Health ABC study
Authors: Powell Danielle S. , Betz Joshua F. , Yaffe Kristine , Kritchevsky Stephen , Strotmeyer Elsa , Simonsick Eleanor M. , Rubin Susan , Houston Denise K. , Pratt Sheila R. , Purchase Helzner Elizabeth , Brewster Katharine K. , Lin Frank R. , Gross Alden L. , Deal Jennifer A. 
Published: October 2022

ObjectiveHearing loss (HL) is highly prevalent among older adults and may lead to increased risk of depressive symptoms. In both cross-sectional and longitudinal analysis, we quantified the association between HL and depressive symptoms, incorporating the variable nature of depressive symptoms and characterizing by race and gender.MethodsData were from the Health, Aging, and Body Composition study. Depressive symptoms were measured using the Center for Epidemiologic Study Depression Scale short form (CES-D 10), defined as CES-D 10 score ≥10 or treatment for depression. Hearing was defined via four-frequency pure-tone average (PTA) decibel hearing level (dB HL), categorized as normal hearing (PTA ≤25 dB HL), mild HL (PTA26-40 dB HL), and ≥moderate HL (PTA &gt; 40 dB HL). Associations at baseline were quantified using logistic regression, incident depressive symptoms using Cox proportional hazard models, and change in depressive symptoms over time using growth mixture models and multinomial logistic regression.ResultsAmong 2,089 older adults (1,082 women, 793 Black; mean age 74.0 SD: 2.8), moderate or greater HL was associated with greater odds of concurrent [Odds Ratio (OR):2.45, 95% CI:1.33, 4.51] and incident depressive symptoms [Hazard Ratio (HR):1.26, 95% CI:1.00, 1.58]. Three depressive symptom trajectory patterns were identified from growth mixture models: low, moderate increasing, and borderline high depressive symptom levels. Those with moderate or greater HL were more likely to be in the borderline high depressive-symptom trajectory class than the low trajectory class [Relative Risk Ratio (RRR):1.16, 95% CI:1.01, 1.32].ConclusionsHL was associated with greater depressive symptoms. Although findings were not statistically significantly different by gender and race, estimates were generally stronger for women and Black participants. Investigation of psychosocial factors and amelioration by hearing aid use could have significant benefit for older adults' quality of life.
The involvement of homeobox-C 4 in predicting prognosis and unraveling immune landscape across multiple cancers via integrated analysis
Authors: Xiao Junbo , Li Ying , Liu Yajun , Chen Yiqian , He Zixuan , Peng Shifang , Yin Yani 
Published: October 2022

Background: There has been growing evidence that the aberrantly expressed Homeobox-C 4 (HOXC4) plays crucial roles in the development of some cancer types. However, it remains unclear as far as its expression patterns and prognostic significance are concerned, as is tumor immunity.Methods: To investigate the expression levels and prognostic implications of HOXC4, multiple data sources were used in conjunction with quantitative real-time polymerase chain reaction (qRT-PCR) verification. Afterward, diverse immunological-related analyses, along with anti-cancer drug sensitivity, were performed in a number of cancer types. A further exploration of the underlying mechanisms of HOXC4 in tumorigenesis and immunity was carried out using the Gene Set Enrichment Analysis (GSEA) and the Gene Set Variation Analysis (GSVA).Results: Based on extensive database mining, HOXC4 was ubiquitously expressed across 21 tumor cell lines and significantly higher than that of normal tissues in 21 tumor types. The outcome of survival analysis including overall survival (OS), disease-free interval (DFI), disease-specific survival (DSS) and progression-free interval (PFI) revealed that upregulation of HOXC4 expression in several cancers was associated with worse prognosis. Additionally, HOXC4 was observed to correlate closely with colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), lower grade glioma (LGG), liver hepatocellular carcinoma (LIHC), rectum adenocarcinoma (READ), and thyroid carcinoma (THCA) in terms of tumor immune cells infiltration. As a result of our comprehensive pan-cancer study, we have identified a significant link between the expression of HOXC4 and the efficacy of immunotherapy-related treatments, together with anti-cancer drug sensitivity. As a final note, HOXC4 was found to modulate multiple signaling pathways involved in tumorigenesis and immunity.Conclusion: HOXC4 has been implicated in our study for the first time as an oncogene in cancers with a poor prognosis, potentially laying the groundwork for promising clinical biomarkers and immunotherapy approaches.