bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of Glaucoma Therapy Escalation After Descemet-Stripping Automated Endothelial Keratoplasty To Treat Pseudophakic Bullous Keratopathy: A Nested Case-Control Study
Authors: AlDarrab Abdulrahman 
Published: November 2022

Purpose:To study the determinants of glaucoma therapy escalation (GTE) after Descemet-stripping automated endothelial keratoplasty (DSAEK) for pseudophakic bullous keratopathy in an eye-care hospital in Saudi Arabia.Methods:This nested case-control study evaluated patients who required medical or surgical treatment for controlling glaucoma after DSAEK (defined as GTE; GTE group). A group of patients who did not require any intervention post-DSAEK served as controls (control group). Data were collected on preoperative, intraoperative, and postoperative parameters for DSAEK. Variables were compared between groups to evaluate risk factors for GTE and graft failure.Results:The study sample comprised 117 eyes (40 in the GTE group and 77 in the control group). Glaucoma was present in 20 (17.1%) of the eyes before DSAEK. The median duration of follow-up was 27 months [Interquartile range (IQR): 24; 42]. Intraoperative complications occurred in 4 eyes, and 2 eyes had a decentered donor button. Graft failure causing vision impairment and GTE at the final follow-up were noted in 19 (16.2%) and 40 (34.2%) eyes, respectively. Glaucoma prior to DSAEK was significantly associated with GTE [odds ratio (OR) = 6.4; 95% confidence interval (CI) 2.4; 18.3;P= 0.0004]. A history of penetrating keratoplasty (PK) was significantly associated with GTE after DSAEK [OR = 6.2 (95% CI 1.5; 24.7)P= 0.008]. At the last visit, GTE and graft failure were positively associated (OR = 27.2,P< 0.005).Conclusion:Escalation of glaucoma therapy was warranted in one in 3 eyes that had undergone DSAEK. GTE and graft failure are interrelated complications. Patients with glaucoma and PK have a higher risk of GTE post-DSAEK.
Workplace Trauma with Massive Intraorbital Foreign Body, A Dramatic Outcome
Authors: Nassim Hala M. , Alam Mohammed H. , Alshuraim Saleh M. , Alfrayyan Abdullah A. 
Published: November 2022

Background:
Intra-orbital foreign bodies [IOFB] are considered a rare condition, and an enormous challenge to surgeons, as it might be difficult to diagnose in some cases even with the current advances in imaging technology. Retained IOFB can be a cause of major visual morbidity and blindness, especially in the working population.

Purpose:
In this article, we report a case of IOFB that occurred as a result of workplace related trauma while drilling ceramic.

Methods:
Case report and literature review using PubMed.

Case Presentation:
we present a case of a 30 years old male, not known to have any medical illness, the patient presented to the emergency department after getting trauma while drilling ceramic. Orbital computed tomography [CT] showed multiple high-density objects situated in a circumferential pattern around the globe.

Results:
The patient underwent lateral canthotomy and cantholysis in the emergency department, followed by three exploratory operations to remove intraorbital foreign bodies [FBs]
. Luckily, the patient in our case regained a 0.5 visual acuity, with an impressive improvement in the extraocular muscle motility, with only mild restriction in the upper and lower gazes. The patient was followed up for 2 years after the incident, he was stable during that period.

Conclusions:
IOFB is an ophthalmological emergency, careful history, examination, and investigations are important steps in diagnosing IOFB since it can be easily missed when depending solely on imaging. Timely management is crucial to prevent irreversible complications.
Development of ISO18363-4 / AOCS Cd29f-2021: A new standardized method to quantify MCPDE and GE in edible oils
Authors:   Loders Croklaan BV, Zwagerman Ralph 
Published: November 2022

In August 2021 the International Organization for Standardization (ISO) Â has published part 4 to the ISO 18363 series of methods to quantify MCPD- and glycidyl esters in edible oils. AOCS will follow by publishing the method as AOCS Cd 29f-2021 in 2022. This new method describes a high throughput method for the quantification of these process contaminants, for which the EU has recently updated its legislation on the maximum levels allowed in edible oils. In short, its chemistry is based on fast alkaline transesterification of the fat matrix, which also cleaves the MCPDE and GE esters before the analytes are derivatization and analysis by GC-MS/MS. An in vitro correction for glycidol overestimation, which can occur in alkaline environment, is included. In the fall of 2018 both ISO and AOCS technical committees agreed to standardize the method in cooperation. An overview is given of the standardization project together with statistical data collected during the collaborative study together with a short introduction to the chemistry of the method.
Serendipitous production of industrially useful p-cymene by catalytic dehydration
and isomerization of perillyl alcohol
Authors:   USDA ARS NCAUR, Moser Bryan , Doll Kenneth ,   USDA ARS
            NCAUR, Jackson Michael ,   USDA ARS
            NCAUR
Published: November 2022

As part of our continuing efforts to produce aliphatic polyesters from fats and
oils, we were originally attempting to esterify 9-decenoic acid with perillyl alcohol
[(4-isopropenyl-1-cyclohexen-1-yl)methanol] in the presence of catalytic
para-toluenesulfonic acid in refluxing toluene to give tris-unsaturated perillyl
decenoate as a monomer for subsequent ADMET and thiol-ene polymerization. The
esterification procedure had proven simple and effective for several previous
esterifications involving different alcohol/acid combinations, but in this case the
expected ester was not observed. Instead, a mixture comprised of unreacted perillyl
alcohol and 9-decenoic acid and an unexpected and curiously high amount of p-cymene
(31%; 4-isopropyltoluene) was obtained. With this serendipitous discovery in hand, we
set out to improve the yield of industrially useful p-cymene from perillyl alcohol
utilizing homogenous acid catalysis.Â We thus report the dehydration and isomerization
of renewable perillyl alcohol as a 3.0 M solution in refluxing toluene to p-cymene in
91.1% yield utilizing catalytic para-toluenesulfonic acid. This approach represents a
bio-based alternative to the conventional petrochemical Friedel-Crafts alkylation of
toluene with propylene, which has several significant drawbacks. Industrial applications
of p-cymene include use as a green solvent, heat transfer medium, ligand for catalysts,
starting material for other industrial chemicals, and as a constituent in fragrances and
perfumes.
Enzyme Developments in Oleochemicals and Surfactants
Authors:   Novozymes Malaysia Sdn
            Bhd, Rushworth Martin , Yee Hon Seng ,   Novozymes
            Malaysia
Published: November 2022

Since the late 2010's Enzyme processing is being used to produce biodiesel methyl
esters in over 31 commercial plants in all corners of the globe. The flexibility and
high yield benefits of enzyme processing have driven this adoption of biotechnology.
However esterification of triglycerides or fatty acids with methanol is only one of many
possibilities for enzyme processing in oleochemistry. Commercially available enzyme
technology are increasingly being used for a variety of processes including
esterification, transesterification, hydrolysis and glycerolysis. Reactions can be
driven either to the right or to the left by control of process conditions. Enzyme
processing invariably reduces CO2 emissions compared with thermochemistry, improves
productÂ Â purity by eliminating harmful side reactions, and reduces harmful effluent
discharges into the worldâ€™s waterways. The door is now open for enzymes to displace
thermochemistry for a variety of processes in the oleochemical industry. Whenever a
hydroxyl moiety meets up with a carboxylic acid an enzymatic reaction can take place.
Simple examples would be for simple emulsifiers and emollients such as isopropyl
myristate or cetyl ricinoleate. Other examples would include the reaction of fatty acids
with triethanolamine to produce mono or diesters of ethanolamine for use in skincare, as
a building block for betaines, or as a feedstock for cationic surfactants. Less obvious
and probably further out on the time horizon would be surfactants products from the
esterification of saccharides with fatty acids or alcohols for sugar based surfactants
and alkyl glucosides. As the oleochemical and surfactant industry moves from
thermochemistry to biotechnology the world will see measurable improvements in GHG
emissions, effluent discharges and sustainability.
Composición corporal, presencia de anorexia nerviosa y sintomatología asociada en bailarines de danza folclórica/Body composition, presence of anorexia nervosa and associated symptoms in folkloric dancers
Authors: Ortega-Luyando Mayaro , Sánchez-Trejo Brenda Gabriela , Amaya-Hernández Adriana , Alvarez-Rayón Georgina Leticia , Balderrama-Díaz Raquel , Mancilla-Díaz Juan Manuel 
Published: November 2022

Dada la exigencia en la disciplina dancística sobre los requerimientos corporales del bailarín, se han llevado a cabo diversos estudios sobre trastornos alimentarios (TA), sin embargo, son escasos los datos en bailarines de danza folklórica. Por tal motivo, el objetivo del presente trabajo fue conocer la composición corporal, imagen corporal, sintomatología y presencia de anorexia nerviosa en bailarines de danza folklórica profesionales (n = 37), recreativos (n = 37) y en muestra comunitaria (n = 37). El estudio se llevó a cabo en dos fases, en la primera se aplicaron los instrumentos EAT-26 y BSQ, además, se calculó el porcentaje de grasa corporal (PGC), el índice de masa corporal (IMC) y la masa muscular esquelética (MME). En la segunda fase se entrevistaron a aquellos que rebasaron punto de corte del EAT-26 y/o BSQ así como a un grupo control de la misma muestra que no haya rebasado ningún punto de corte para descartar falsos negativos. Solo se encontraron diferencias entre grupos en IMC y en PGC. De acuerdo con las entrevistas, ningún participante fue diagnosticado con anorexia nerviosa pero sí con sintomatología de TA. Se concluye que los estándares corporales exigidos en danza folklórica, son lo suficientemente altos como para que los bailarines realicen conductas de riesgo que podrían comprometer su salud física y psicológica.
Management of Glaucoma Medication Induced Dry Eye Disease with Self-retained Cryopreserved Amniotic Membrane
Authors: Vendal Zarmeena 
Published: November 2022

BackgroundApproximately half of glaucoma patients have dry eye disease (DED) due to anti-glaucoma medication use. Herein, we evaluated the effectiveness of self-retained cryopreserved amniotic membrane (AM) in managing glaucoma-induced DED.
MethodsA retrospective chart review was conducted on consecutive patients treated with self-retained cryopreserved AM (Prokera Slim, BioTissue, Miami, FL) for ocular surface disease induced by chronic use of glaucoma medication. Data collected included demographics, diagnosis, associated signs and symptoms, concomitant therapies, and benefit duration.
ResultsEight eyes of eight female patients (aged 80.0 ± 3.9 years) developed DED from chronic use (8.4 ± 2.3 years) of glaucoma medication. DED was refractory despite use of conventional therapies, including topical cyclosporine (n=7), gels (n=5), artificial tears (n=5), and lifitegrast (n=2). However, after treatment with self-retained cryopreserved AM, SPK grade significantly improved from 3.25 ± 0.7 to 0.38 ± 0.5 (p=0.01). Furthermore, visual acuity (VA) improved in all patients by an average of 1.4 ± 0.5 lines (range: 1-2), with a significant improvement in LogMAR VA observed post-treatment (logMAR .28 to .16, p=0.01). This was accompanied by decreased pain (n=5), decreased foreign body sensation (n=5), and improved comfort (n=2) that lasted an average duration of 5.3 ± 1.0 months.
ConclusionThis retrospective study suggests that a single placement of self-retained cryopreserved AM can restore corneal surface health with a lasting benefit in patients with glaucoma-induced DED who are refractory to conventional therapy directly or indirectly by promoting blinking and tearing reflexes.
Construction and Application of a Refined Model for the Optimal Allocation of Water Resources --- Taking Guantao County as an Example
Authors: Han Yuhang , Li Yanbin , Li Hongxing , Du Xuefang , Wang Qian , Wang Xin , Zhu Xinli 
Published: November 2022

The traditional optimal allocation of water resources cannot reflect the
specific water distribution of a water consumption unit. To resolve the
issue, an improved model for the optimal allocation of water resources
was developed in combination with the existing gridding concept and
remote sensing technologies to minimize water scarcity and maximize
economic benefit. This model incorporates the water supply scopes and
water users of the water sources in a region in the form of cells, using
multiple water resources, objectives, and users in the region as the
base points. Further, the Particle Swarm Optimization (PSO) algorithm
was employed to solve this model. The results reveal as follows: First,
the northeast, west, and southeast areas of Guantao County have the
lowest water demands, while the east lower-middle half has the greatest.
Second, it is estimated that in the years of the plan (P = 50%), the
county’s total water demand will be 118,871,900 m ,
which can be met by the total available water supply (125,281,800 m
); the economic benefit will reach 4,086,500 Yuan in
the target year of the plan. Third, the region refined water resources
optimizing the allocation is favorable to lowering groundwater
exploitation, coping with the water resources deficit, and promoting the
rational allocation and management of water resources.
Assessment of malalignment factors related to Invisalign treatment time aided by automated imaging processes
Authors: Lee Sanghee , Wu Tai-Hsien , Deguchi Toru , Ni Ai , Lu Wei-En , Minhas Sumeet , Murphy Shaun , Ko Ching-Chang 
Published: November 2022

ABSTRACTObjectivesTo identify predictors regarding the type and severity of malocclusion that affect total Invisalign treatment duration based on an intraoral digital scan.Materials and MethodsThe subjects of this retrospective clinical cohort were 116 patients treated with Invisalign. A deep learning method was used for automated tooth segmentation and landmark identification of the initial and final digital models. The changes in the six degrees of freedom (DOF), representing types of malalignment, were measured. Linear regression was performed to find the contributing factors associated with treatment time. In addition, the Peer Assessment Rating (PAR) score and a composite score combining 6 DOF were correlated separately to the treatment time.ResultsThe number of trays differed between sexes (P = .0015). The absolute maximum torque was marginally associated with the total number of trays (P = .0518), while the rest of the orthodontic tooth movement showed no correlation. The composite score showed a higher correlation with the total number of trays (P = .0045) than did individual tooth movement. Pretreatment upper and lower anterior segment PAR scores were positively associated with the treatment time (P &lt; .001).ConclusionsThere is not enough evidence to conclude that certain types of tooth movement affect the total aligner treatment time. A composite score seems to be a better predictor for total treatment time than do individual malalignment factors in aligner treatment. Upper and lower anterior malalignment factors have a significant effect on the treatment duration.
Cardiovascular Outcomes in Patients With Both Diabetes and Phenotypic Familial Hypercholesterolemia: A Nationwide Register-Based Cohort Study
Authors: Brinck Jonas , Hagström Emil , Nåtman Jonatan , Franzén Stefan , Eeg-Olofsson Katarina , Nathanson David , Eliasson Björn 
Published: November 2022

OBJECTIVE
Patients with diabetes or familial hypercholesterolemia (FH) have an increased incidence of cardiovascular diseases compared with the population, but whether this risk is exacerbated in patients with combined traits is unknown.

RESEARCH DESIGN AND METHODS
In this Swedish nationwide, register-based cohort study, patients with diabetes were included between 2002 and 2020. Adjusted Cox proportional hazards models were used to assess the risk of cardiovascular events in patients with or without phenotypic FH (≥6 points for phenotypic FH according to Dutch Lipid Clinic Network criteria) compared with general population control subjects without diabetes as reference.

RESULTS
A total of 45,585 patients with type 1 diabetes (227,923 control subjects) and 655,250 patients with type 2 diabetes (655,250 control subjects) were followed for a median of 14.1 and 7.9 years, respectively. Of those, 153 and 7,197, respectively, had phenotypic FH. Compared with control subjects, patients with diabetes and phenotypic FH had higher risk of cardiovascular mortality (type 1: hazard ratio 21.3 [95% CI 14.6–31.0]; type 2: 2.40 [2.19–2.63]) and of a cardiovascular event (type 1: 15.1 [11.1–20.5]; type 2: 2.73 [2.58–2.89]). Further, patients with diabetes and phenotypic FH had higher LDL-cholesterol levels during observation (P &lt; 0.05) and increased risk of all major cardiovascular outcomes (P &lt; 0.0001) than patients with diabetes but without FH. The proportion receiving lipid-lowering treatment was higher in patients with phenotypic FH (P &lt; 0.0001).

CONCLUSIONS
Patients with both diabetes and phenotypic FH are more at risk for adverse cardiovascular outcomes and have higher LDL-cholesterol levels despite receiving intensified lipid-lowering therapy.
Penerapan Model Problem Based Learning untuk Meningkatkan Hasil Belajar Tematik (Muatan Pelajaran Bahasa Indonesia) Siswa Kelas III
Authors: Cahyono I Ketut Somoarta , Rati Ni Wayan 
Published: November 2022

Rendahnya hasil belajar tematik siswa sekolah dasar kususnya pada muatan bahasa Indonesia cenderung disebabkan oleh proses pembelajaran yang masih berpusat pada guru. Penelitian ini bertujuan untuk mengetahui peningkatkan hasil belajar tematik (muatan pelajaran Bahasa Indonesia) siswa kelas III dengan menerapkan model PBL. Penelitian ini merupakan penelitian tindakan kelas yang dilaksanakan dalam 2 siklus penelitian, dimana masing-masing siklus memiliki 4 tahap pelaksanaan yang terdiri dari tahap perencanaan, pelaksanaan, observasi dan refleksi. Adapun subjek penelitian yang diteliti adalah siswa kelas III Sekolah Dasar. Teknik analisis yang digunakan adalah analisis statistik deskriftif, dengan menggunakan indikator keberhasilan. Hasil analisis siklus I diperoleh bahwa, hasil belajar tematik (muatan pelajaran Bahasa Indonesia) siswa masih berada di kategori rendah, dimana persentase rata- rata kelas yang diperoleh sebesar 68,1% dengan ketuntasan klasikal sebesar 51,6%. Dari hasil analisis tersebut dapat diketahui bahwa dalam tindakan siklus I masih terdapat kendala atau hambatan, sehingga belum mencapai keberhasilan, maka dari itu penelitian dilanjutkan ke siklus II, dengan memperhatikan hasil refleksi siklus I. Pada siklus II penelitian, terdapat peningkatan hasil belajar tematik (muatan pelajaran Bahasa Indonesia) siswa, dimana persentase rata- rata kelas yang diperoleh sebesar 77,6%. Setelah dikonversikan menunjukkan bahwa hasil belajar siswa pada siklus II berada pada kriteria sedang. Persentase ketuntasan klasikal belajar siswa pada siklus II mencapai 80,6% dan telah melampaui kriteria ketuntasan belajar siswa secara klasikal minimal 70% dari seluruh siswa telah mencapai nilai ≥ 70. Simpulan yang dapat diambil dari hasil tersebut adalah penerapan model PBL dapat meningkatkan hasil belajar tematik (muatan pelajaran Bahasa Indonesia) siswa.
Pengaruh Kepemimpinan Kepala Sekolah dan Iklim Sekolah terhadap Kedisiplinan Guru Sekolah Dasar
Authors: Vebriani Niasari , Utomo Slamet , Su'ad  
Published: November 2022

Masih banyak terjadi pelanggaran kedisiplinan yang dilakukan oleh para guru. Penelitian ini bertujuan untuk menganalisis dampak kepemimpinan kepala sekolah dan iklim sekolah terhadap kedisiplinan guru sekolah dasar. Pendekatan penelitian yang digunakan adalah penelitian kuantitatif. Populasi dari penelitian ini adalah guru PNS yang berjumlah 278 orang, sampel sebanyak 74 orang dengan menggunakan teknik random sampling. Metode pengumpulan data yang digunakan adalah metode kuesioner. Analisis data dilakukan dengan menggunakan analisis regresi menggunakan Program SPSS 24 for windows. Hasil penelitian menunjukkan bahwa gaya kepemimpinan kepala sekolah berpengaruh terhadap kedisiplinan guru dibuktikan dengan t hitung sebesar 3, 143 lebih besar dari nilai t tabel 0,679 dengan probabilitas signifikasi adalah 0,001 lebih kecil dari α = 0,25. Iklim sekolah berpengaruh terhadap kedisiplinan guru yang dibuktikan dengan t hitung sebesar 2,909 lebih besar dari nilai t tabel 0,679. dengan probabilitas signifikasi adalah 0,016 lebih kecil dari α = 0,25. Gaya kepemimpinan dan iklim sekolah berpengaruh terhadap kedisiplinan guru, dibuktikan dengan hasil dari uji hipotesis menunjukkan nilai F hitung sebesar 18, 567 lebih besar dengan nilai F tabel 3,98 dengan probabilitas signifikasi adalah 0,000 lebih kecil dari α = 0,25. Hasil penelitian tersebut menunjukkan bahwa gaya kepemimpinan kepala sekolah dan iklim sekolah merupakan dua faktor yang turut memengaruhi dan menentukan kedisiplinan guru di sekolah.
Instrumen E-Assessment Berbasis Quizizz tentang Materi Sistem Koordinasi untuk Kelas XI SMA/MA
Authors: Nurhidayah Indah , Ardi  
Published: November 2022

Pembelajaran daring mengharuskan adanya transisi proses pembelajaran melalui sistem online, termasuk dalam proses asesmen hasil belajar. Namun, guru masih jarang memanfaatkan aplikasi untuk asesmen online (e-assessment). Penelitian ini bertujuan untuk menciptakan instrumen e-assessment berbasis Quizizz tentang materi sistem koordinasi untuk kelas XI. Jenis penelitian ini adalah penelitian pengembangan (Research and Development) dengan model pengembangan 4-D. Subjek penelitian terdiri dari 2 orang dosen biologi dan 1 orang guru Biologi. Data diperoleh melalui angket validasi dan angket uji praktikalitas dengan teknik analisis deskriptif kualitatif. Penelitian ini menghasilkan nilai rata-rata validitas logis dari segi materi adalah 93,75% dengan kriteria sangat valid dan pada aspek konstruksi diperoleh nilai rata-rata 91,47% dengan kriteria sangat valid. Ditinjau dari segi aspek bahasa didapatkan nilai rata-rata 92,50% dengan kriteria sangat valid dan pada aspek kegrafikan diperoleh nilai rata-rata 92,50% dengan kriteria sangat valid. Rata-rata nilai validitas yang diperoleh sebesar 92,85% dengan kriteria sangat valid. Hasil rata-rata nilai praktikalitas oleh guru sebesar 97,70% dengan kriteria sangat praktis dan peserta didik sebesar 84,80% dengan kriteria sangat praktis. Maka, dihasilkan instrumen e-assessment berbasis Quizizz tentang materi sistem koordinasi untuk kelas XI yang valid dan praktis. Implikasi penelitian ini diharapkan dapat dimanfaatkan oleh guru sebagai instrumen asesmen dalam pembelajaran biologi di sekolah.