bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viewpoint: The Case for Non-Invasive Central Aortic Pressure Monitoring in the Management of Hypertension
Authors: Kesten Steven , Qasem Ahmad , Avolio Alberto 
Published: October 2022

AbstractElevated central aortic pressure indices (e.g., systolic pressure and pulse pressure) predict cardiovascular (CV) events and mortality in addition to structural changes (e.g., left ventricular hypertrophy, carotid intima-media thickness and reduced glomerular filtration rate). These elevated risks have been shown in multiple studies to be superior to, and in others, at least as high as that associated with brachial pressures. Threshold values for the diagnosis of elevated central arterial pressures have been defined and can be considered target goals of treatment. Measurements of central arterial pressures can be incorporated into the current approaches to hypertension management utilizing currently available non-invasive devices that measure central pressures during the measurement of brachial BP. The objective of this review is to outline the rationale and evidence supporting incorporation of central aortic pressure monitoring into the care of patients with hypertension.
Hydrologic modeling of a perennial firn aquifer in southeast Greenland
Authors: Miller Olivia , Voss Clifford I. , Solomon D. Kip , Miège Clément , Forster Richard , Schmerr Nicholas , Montgomery Lynn 
Published: October 2022

AbstractA conceptual model, based on field observations and assumed physics of a perennial firn aquifer near Helheim Glacier (southeast Greenland), is evaluated via steady-state 2-D simulation of liquid water flow and energy transport with phase change. The simulation approach allows natural representation of flow and energy advection and conduction that occur in vertical meltwater recharge through the unsaturated zone and in lateral flow within the saturated aquifer. Agreement between measured and simulated aquifer geometry, temperature, and recharge and discharge rates confirms that the conceptual field-data-based description of the aquifer is consistent with the primary physical processes of groundwater flow, energy transport and phase change. Factors that are found to control simulated aquifer configuration include surface temperature, meltwater recharge rate, residual total-water saturation and capillary fringe thickness. Simulation analyses indicate that the size of perennial firn aquifers depends primarily on recharge rates from surface snowmelt. Results also imply that the recent aquifer expansion, likely due to a warming climate, may eventually produce lakes on the ice-sheet surface that would affect the surface energy balance.
Africa and Ethnic Politics
Authors: Koter Dominika 
Published: October 2022

AbstractThis article provides an overview of the theoretical and empirical contributions made by scholars of ethnic politics in Africa. I first discuss the definitions and measures of ethnic politics most commonly used. I then review the main explanations of the prevalence of ethnic politics. The following sections discuss the consequences of politicized ethnicity, variation in ethnic politics, and the relationship between ethnicity and other social identities, such as national identity. I conclude with some remarks about existing gaps and promising future avenues of research.
A numerical study of hypersonic laminar film cooling
Authors: Yang X. , Badcock K. J. , Richards B. E. 
Published: October 2022

AbstractA computational study has been performed to investigate the effectiveness of film cooling in hypersonic laminar flows. Both the primary and the coolant flow are air. First, three different primary flow conditions are used for validation. A uniform boundary condition at the slot exit is found to give unrealistic predictions of the heat transfer rate, whilst a boundary condition involving extended coolant inlet gives improvement. Then five coolant injection rates and three slot heights are examined. It is confirmed that increasing the coolant injection rate can increase the film cooling effectiveness for laminar cases. But slot height does not play an important role under the flow conditions in this study. The computational results are compared with the experimental results and good agreement is achieved.
Iron-enriched Aspergillus oryzae as an alternative to iron sulphate to limit iron accumulation, growth and motility of the enteric pathogen S. Typhimurium
Authors: Miller Katelyn M. , Reddy Manju B. , Quashie David , Velez Frank J. , Ali Jamel , Singh Prashant , Hennigar Stephen R. 
Published: October 2022

AbstractExcess unabsorbed iron in the gastrointestinal tract may select for enteric pathogens and increase the incidence and severity of infectious disease. Aspergillus oryzae (Ao) is a filamentous fungus that has the ability to accumulate and store large amounts of iron, and when used as a supplement or fortificant, has similar absorption to ferrous sulphate (FeSO4) in humans. The objective of this study was to determine the effect of iron-enriched Ao (Ao iron) compared with FeSO4 on iron accumulation, growth and motility of the Gram-negative enteric pathogen, S. Typhimurium. S. Typhimurium was cultured in media containing no added iron or 1 μM elemental iron as either Ao iron or FeSO4. S. Typhimurium cultured with FeSO4 accumulated more iron than those cultured with Ao iron. Genes regulated by the iron-activated transcriptional repressor, Fur, did not differ between control and Ao iron, but decreased in S. Typhimurium cultured with FeSO4 compared with both groups. Growth of S. Typhimurium was greater when cultured with FeSO4 compared with Ao iron and control. S. Typhimurium swam faster, had greater acceleration and travelled further when cultured with FeSO4 compared with Ao iron and control; swim speed, acceleration and distance travelled did not differ between Ao iron and control. These findings provide evidence that Ao iron reduces the virulence of a common enteric pathogen in vitro. Further research is required to determine whether iron-enriched Ao is a suitable iron supplement to improve iron delivery in areas with a high infection burden.
Characterising the use, users and effects of a health app supporting lifestyle changes in pregnant women
Authors: Koivuniemi Ella , Raats Monique M. , Ollila Helena , Löyttyniemi Eliisa , Laitinen Kirsi 
Published: October 2022

AbstractThe study objective was to (1) compare, through a randomised pilot intervention study, the effects of a standard health app and an enhanced health app, with evidence-based information regarding healthy lifestyle, on gestational weight gain, diet quality and physical activity in pregnant women. The sub-objectives were to (2) characterise app use and users among pregnant women and to (3) compare, in the overall sample regardless of the intervention, whether the frequency of the health app use has an effect on the change in gestational weight, diet quality and physical activity. Women recruited through social media announcements (n 1038) were asked to record their lifestyle habits in the app from early pregnancy to delivery. Self-reported weight, diet quality and physical activity were assessed in early and late pregnancy with validated online questionnaires. No benefits of the enhanced app use were shown on the lifestyle habits. Nevertheless, frequent app users (use ≥ 4·7 weeks) in the enhanced app group had a higher physical activity level in late pregnancy compared with those in the standard app group. Overall, extensive variation was found in the number of recordings (median 59, interquartile range 19–294) and duration of app use (median 4·7, interquartile range 1·1–15·6 weeks). Frequent app users had higher education level, underweight/normal weight, better diet quality and were non-smokers, married and primipara more likely than occasional app users/non-users. Physical activity among app users decreased less compared with non-users over the pregnancy course, indicating that app use could motivate to maintain physical activity during pregnancy.
Water balance and urinary parameters of lambs fed diets containing cactus cladodes varieties
Authors: Silva T. G. P. , Lopes L. A. , Carvalho F. F. R. , Guim A. , Soares P. C. , Silva Júnior V. A. , Batista A. M. V. 
Published: October 2022

AbstractThe water balance and urinary parameters of lambs fed diets containing cactus cladodes varieties were evaluated. Thirty-six uncastrated male Santa Inês lambs (22.0 ± 2.9 kg initial body weight) were distributed in a completely randomized design, with three treatments and 12 replicates. The animals were fed a control diet (Tifton-85 hay as exclusive roughage), Miúda or Orelha de Elefante Mexicana (OEM) cactus-based diets. Urine samples were collected 45 days after the introduction of the tested diets, and voluntary water intake was measured over 10 days, during the experimental period. Diets containing Miúda or OEM cactus caused a reduction of 68.35 and 77.03% in voluntary water intake, respectively. In addition, the Miúda cactus cladodes caused urinary alkalinization (pH = 8.14) and reduction in the urinary excretion index (UEI) and on the fractional excretion rate (FER) of total calcium (Ca). The diets with OEM cactus cladodes caused higher oxalates intake (6.21 g/day) and increase in urinary volume. Regardless of the variety, there was a reduction in the urinary concentrations of urea, creatinine, total proteins, Ca, phosphorus (P), UEI of urea and P, as well as in FER of P, compared to the control diet. Urinary Mg content and UEI of uric acid and Mg increased and FER ofPdecreased by diets supplemented with different varieties of cactus cladodes. In conclusion, the cactus cladodes increased water intake and retention, and diuresis in lambs, altered urine parameters, without compromising kidney function.
Studying the seasonality of conceptions among five distinct population subgroups in mainland Greece: a story of similarities and variability
Authors: Zafeiris K. N. , Tsimbos C. , Verropoulou G. , Hatzisavva K. 
Published: October 2022

AbstractThe paper studies seasonality of conceptions among five distinct population subgroups of mainland Greece for the period 1951-2002. The populations explored include those residing in Metsovo, Dion, Organi, Kehros, as well as a “General” Sample consisting of persons located in various areas of continental Greece. The populations under investigation present diverse characteristics regarding religion, cultural background, socio-economic status etc. Records of births were derived from the Vital Registration System of the respective municipalities and communities of the populations under research were constructed. The date of child conception was estimated as the recorded date of birth minus 260 days.The analysis focuses, among others, on the construction of seasonal indices, applying a variant ratio to moving averages method which reveal, in relative terms, the seasonality of the phenomenon. Subsequently, these ratios are considered as the dependent variable in regression models while months, expressed in terms of dummy variables, are introduced as predictors. Four main sub-periods are considered; 1951-64, 1965-80, 1981-92 and 1992-2002. The findings show that the extent of seasonality differs between periods as well as between the five population subgroups though the phenomenon becomes less prominent over time in all cases. There is a tendency of an increased number of conceptions among mountainous populations during summer, irrespective of religion or socio-economic status, possibly partly due to environmental factors (i.e. seasonal workload, domestic organisation of extended families, etc). Nevertheless, the mountainous populations differ regarding the intensity and duration of this phenomenon. By contrast, in Dion, a lowland Christian Orthodox population, conceptions increase after Easter and remain elevated until June.
Impact of manual crimping on stapedotomy outcomes
Authors: Couvreur F , Schlegel-Wagner C , Linder T 
Published: October 2022

AbstractBackgroundThe impact of tight stapes crimping on hearing is a matter of debate. Several studies postulate that tight crimping is essential for lifelong success, whereas others have debated whether firm attachment leads to incus necrosis. Several types of prostheses with different coupling mechanisms have been developed, and manual crimping remains the most frequently used technique. This study investigates whether tightness really does affect hearing outcome.MethodsThe hearing results of patients who underwent primary stapedotomies using three different titanium pistons were analysed. The surgeons categorised the firmness of the piston attachment into ‘tight’ and ‘loose’ crimping groups. Hearing outcome and reasons for revision surgical procedures were investigated.ResultsThe mean post-operative air–bone gap for frequencies of 0.5–4 kHz was 8.80 dB for the tight crimping group (n = 308) and 9.55 dB for the loose crimping group (n = 39). No significant difference was found (p = 0.4650). Findings at revision procedures were comparable (1.6 per cent vs 5 per cent).ConclusionAlthough firm crimping is strongly advised, a movable loop upon palpation does not lead to unsatisfactory hearing results, and does not mandate piston replacement or bone cement use.
Hazardous Changes in Soil CO2 Emissions at Vulcano, Italy, in 2021
Authors: Di Martino R. M. R. , Gurrieri S. , Camarda M. , Capasso G. , Prano V. 
Published: October 2022

AbstractThe La Fossa volcano on the Island of Vulcano, Italy, showed signs of more energetic fumarolic–solfataric activity during 2021. Several increases in volcanic gas emissions and seismicity, namely, “crisis,” punctuated the passive degassing at Vulcano that had ensued after the last 1888–1890 vulcanian eruption. Most of the gases (i.e., up to 90%) were emitted at the crater cone while the diffuse degassing of CO2 at Vulcano Porto accounted for more than 10% of the volcanic emissions. Two anomalous degassing zones at the base of the volcanic cone (i.e., Palizzi and Faraglione) showed notable changes in the gas output during the volcanic crisis. In these zones, increases of soil CO2 flux (φCO2) had several practical implications other than of volcanological interest, owing to the risk related to people's exposure to volcanic gas emissions. The results of this study reveal variations of the average φCO2 from 74 g m−2 d−1 during September 2021 to 370 g m−2 d−1 in November 2021, which were 27% and 538% higher than the statistical background since 1988 (φCO2 ≈ 58 g m−2 d−1), respectively. These observations helped in volcanic surveillance at Vulcano. The soil CO2 partitioning determined using both φCO2 and carbon isotope measurements, helped track changes in the volcanic CO2 output from 9.97 · 104 to 101.15 · 104 kg d−1. Estimates for volcanic CO2 suggest that the instability of a magmatic body caused a transition from background fumarolic–solfataric activity toward an unrest event after September 2021.
Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease
Authors: Skrabal Dominik , Rusz Jan , Novotny Michal , Sonka Karel , Ruzicka Evzen , Dusek Petr , Tykalova Tereza 
Published: October 2022

AbstractImprecise vowels represent a common deficit associated with hypokinetic dysarthria resulting from a reduced articulatory range of motion in Parkinson’s disease (PD). It is not yet unknown whether the vowel articulation impairment is already evident in the prodromal stages of synucleinopathy. We aimed to assess whether vowel articulation abnormalities are present in isolated rapid eye movement sleep behaviour disorder (iRBD) and early-stage PD. A total of 180 male participants, including 60 iRBD, 60 de-novo PD and 60 age-matched healthy controls performed reading of a standardized passage. The first and second formant frequencies of the corner vowels /a/, /i/, and /u/ extracted from predefined words, were utilized to construct articulatory-acoustic measures of Vowel Space Area (VSA) and Vowel Articulation Index (VAI). Compared to controls, VSA was smaller in both iRBD (p = 0.01) and PD (p = 0.001) while VAI was lower only in PD (p = 0.002). iRBD subgroup with abnormal olfactory function had smaller VSA compared to iRBD subgroup with preserved olfactory function (p = 0.02). In PD patients, the extent of bradykinesia and rigidity correlated with VSA (r = −0.33, p = 0.01), while no correlation between axial gait symptoms or tremor and vowel articulation was detected. Vowel articulation impairment represents an early prodromal symptom in the disease process of synucleinopathy. Acoustic assessment of vowel articulation may provide a surrogate marker of synucleinopathy in scenarios where a single robust feature to monitor the dysarthria progression is needed.
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Authors: Seim Gretchen L. , John Steven V. , Arp Nicholas L. , Fang Zixiang , Pagliarini David J. , Fan Jing 
Published: October 2022

AbstractPyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial roles in cellular metabolism. These multi-subunit enzyme complexes use lipoic arms covalently attached to their E2 subunits to transfer an acyl group to coenzyme A (CoA). Here, we report a novel mechanism capable of substantially inhibiting PDHC and OGDC: reactive nitrogen species (RNS) can covalently modify the thiols on their lipoic arms, generating a series of adducts that block catalytic activity.S-Nitroso-CoA, a product between RNS and the E2 subunit’s natural substrate, CoA, can efficiently deliver these modifications onto the lipoic arm. We found RNS-mediated inhibition of PDHC and OGDC occurs during classical macrophage activation, driving significant rewiring of cellular metabolism over time. This work provides a new mechanistic link between RNS and mitochondrial metabolism with potential relevance for numerous physiological and pathological conditions in which RNS accumulate.
Incidence of depression in kidney transplant recipients in South Korea: a long-term population-based study
Authors: Cho Semin , Park Sehoon , Kim Ji Eun , Yu Mi-yeon , Baek Seon Ha , Han Kyungdo , Lee Hajeong , Kim Dong Ki , Joo Kwon Wook , Kim Yon Su , Kim Yong Chul 
Published: October 2022

AbstractDepression is associated with impaired quality of life and increased morbidity and mortality in end-stage kidney disease (ESKD) patients and kidney transplantation (KT) recipients. Depression incidence after KT is unclear. We compared depression incidence among KT recipients, ESKD patients, and healthy controls (HCs). We analyzed a nationwide health insurance database in South Korea and identified patients who underwent KT during 2007–2015. Participants were matched for age, sex, and inclusion year. KT and ESKD patients were further matched for hypertension and diabetes mellitus history. The incidence rate (IR, per 1000 patients-years) of depression was compared among KT, ESKD, and HC groups. We analyzed 5,234 patients per group. Depression incidence was markedly lower in KT than ESKD patients (IR, 18.87 vs. 58.03; hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.30‒0.36), but only slightly higher in KT recipients than in HCs (IR, 18.87 vs. 17.49; HR, 1.08; 95% CI, 0.96‒1.22). After adjusting for comorbidities, the depression risk was lower in KT recipients than in HCs (adjusted HR, 0.52; 95% CI, 0.44‒0.62; p < 0.001), whereas it remained higher in ESKD patients than in HCs (adjusted HR, 1.60; 95% CI, 1.36‒1.87; p < 0.001). Among KT recipients, older age, female sex, lower economic status, and more comorbidities were associated with increased depression risk. Incident depression after KT increased mortality, graft failure, and death-censored graft failure risks in KT recipients. Our data suggest a broader role of KT than previously appreciated in terms of improving quality of life by reducing depression risk.
The relationship between the intensity of Gasterophilus intestinalis larvae infection and the serum and salivary humoral immune response in horses
Authors: Pawlas-Opiela Monika , Jawor Paulina , Galli Józef , Zak-Bochenek Agnieszka , Gorczykowski Michał , Galli Joanna , Sołtysiak Zenon , Stefaniak Tadeusz 
Published: October 2022

AbstractInfection with Gasterophilus intestinalis (botfly) larvae often occurs in horses. The aim of the study was to isolate the larvae of G. intestinalis and evaluate the serum and salivary humoral immune response using self-developed ELISA in G. intestinalis infected horses. Blood serum or saliva samples were taken from 125 infected horses and 54 uninfected slaughtered horses. The antigens from G. intestinalis larvae were used for development of ELISA in order to evaluate the intensity of G. intestinalis IgG, IgM, and IgA antibody reactivity in the serum or saliva of naturally infected horses and horses without larvae in the gastrointestinal tract (control group). Serum antibodies against second and third larvae’s stadium antigens reacted significantly more intensively in infected than in healthy horses in IgG (p ≤ 0.001; p ≤ 0.05, respectively) and IgA (p ≤ 0.05;p ≤ 0.001, respectively) classes. Salivary IgG and IgA specific’s antibody reactivity was significantly higher in horses with moderate (p ≤ 0.01) and severe infection (p ≤ 0.001) compared to the healthy horses. The determination of the G. intestinalis IgG and IgA antibody activity in saliva and serum may be used for detecting horses moderately and severely infested with larvae.
Influence of hydroxyapatite nanoparticles on the formation of calcium fluoride surface layer on enamel and dentine in vitro
Authors: Rodemer Tina , Pütz Norbert , Hannig Matthias 
Published: October 2022

AbstractTopical application of different fluoride preparations is considered to be the gold standard of oral prophylaxis measures in preventive dentistry. Hydroxyapatite nanoparticles (nano-HAP) as well, have received considerable attention for dental use in the past few decades. The purpose of this in-vitro study was to analyze the interaction between nano-HAP and different fluoride preparations. In order to investigate the possibility to establish, in the presence of nano-HAP, reproducible calcium fluoride surface layers, specimens were visually examined with regard to the surface coverage’s structure, morphology, homogeneity and stability. Test series based on enamel and dentine specimens, that were obtained from extracted bovine teeth, were conducted. Thereby, sodium fluoride, olaflur, elmex Fluid (10.000 ppm) and an aqueous nano-HAP solution (5%) served as test products and sterile water as reference. First, single application of nano- HAP and fluoride was tested. After 5 min of incubation in the test solution, the surface coverage was examined by scanning electron microscopy (SEM). Furthermore, samples were determined by energy dispersive X-ray spectroscopy (EDX) to identify the present elements of the surface layer, particularly fluoride. To test the calcium fluoride layer’s persistence and stability, samples were exposed to the spray of a dental multifunctional syringe for 20 s using maximum pressure and maximum water supply. In the second application protocol, fluoride and nano-HAP were applied simultaneously and in the third application protocol they were used sequentially. SEM visualisation showed that the simultaneous or sequential addition of nano-HAP led to a distinct change in the surface layer’s structure. Agglomerates of various sizes were formed, with obviously different morphology from the calcium fluoride globules, not covering the surface homogeneously and sprayed off with the multifunctional syringe easily. Application of pure fluoride compounds resulted in a more homogeneous calcium fluoride surface layer with higher persistence in comparison to the combination of fluoride and nano-HAP. Interaction between fluoride and nano-HAP clearly could be proved. On enamel as well as dentine surfaces, the combined application of nano-HAP and fluoride has a negative effect on the stability and persistence of the calcium fluoride surface precipitate.