bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early detection of ureteropelvic junction obstruction in neonates with prenatal diagnosis of renal pelvis dilatation using 1H NMR urinary metabolomics
Authors: Scalabre Aurélien , Clément Yohann , Guillière Florence , Ayciriex Sophie , Gaillard Ségolène , Demède Delphine , Bouty Aurore , Lanteri Pierre , Mure Pierre-Yves 
Published: August 2022

AbstractRenal pelvis dilatation (RPD) is diagnosed in utero on prenatal ultrasonography (US) and can resolve spontaneously. However, isolated RPD can also reflect ureteropelvic junction obstruction (UPJO), which requires surgical treatment to prevent progressive renal deterioration. The diagnosis of UPJO can only be confirmed after birth with repeat US and renal isotope studies. 1H Nuclear Magnetic Resonance spectroscopy (NMR) was performed on urine of newborns with prenatally diagnosed unilateral RPD and healthy controls to identify specific urinary biomarkers for UPJO. The original combination of EigenMS normalization and sparse partial-least-squares discriminant analysis improved selectivity and sensitivity. In total, 140 urine samples from newborns were processed and 100 metabolites were identified. Correlation network identified discriminant metabolites in lower concentrations in UPJO patients. Two main metabolic pathways appeared to be impaired in patients with UPJO i.e. amino acid and betaine metabolism. In this prospective study, metabolic profiling of urine samples by NMR clearly distinguishes patients who required surgery for UPJO from patients with transient dilatations and controls. This study will pave the way for the use of metabolomics for the diagnosis of prenatal hydronephrosis in clinical routine.
Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein
Authors: Hietanen Eero , Tripathi Lav , Brockmann Eeva-Christine , Merilahti Pirjo , Lamminmäki Urpo , Susi Petri 
Published: August 2022

AbstractHuman parechoviruses (PeVs) are common viruses that are associated with a variety of diseases from mild gastrointestinal and respiratory symptoms to severe central nervous system infections. Until now there has not been antibodies for visualizing parechovirus infection. We used E. coli recombinant PeV-A1-VP0 protein as a target in phage display single chain variable fragment (scFv) antibody library panning. Three rounds of panning allowed identification and isolation of several candidate scFv clones, which tested positive in enzyme-linked immunosorbent assay (ELISA) against VP0. Three scFv clones (scFv-55, -59 and -71) with different CDR-3 sequences were further purified and tested in ELISA, Western blot and immunofluorescence microscopy (IFA) against a set of PeV-A1 isolates and a few isolates representing PeV types 2–6. In IFA, all three scFv binders recognized twenty PeV-A1 isolates. ScFv-55 and -71 also recognized clinical representatives of PeV types 1–6 both in IFA and in capture ELISA, while scFv-59 only recognized PeV-A1, -A2 and -A6. PeV-A1-VP0 (Harris strain) sequence was used to generate a peptide library, which allowed identification of a putative unique conformational antibody epitope with fully conserved flanking regions and a more variable core VVTYDSKL, shared between the scFv antibodies. Sequencing of the VP0 region of virus samples and sequence comparisons against parechoviral sequences in GenBank revealed 107 PeV-A1, -A3, -A8, -A17, -A (untyped) sequences with this exact epitope core sequence, which was most dominant among PeV-A1 isolates. These data suggest the first-time isolation of broad range phage display antibodies against human parechoviruses that may be used in diagnostic antibody development.
Application of intentional facial nerve stimulation during cochlear implantation as an electrophysiological tool to estimate the intracochlear electrode position
Authors: Herrmann David P. , Müller-Graff Franz-Tassilo , Kaulitz Stefan , Cebulla Mario , Kurz Anja , Hagen Rudolf , Neun Tilmann , Rak Kristen 
Published: August 2022

AbstractThis proof of concept describes the use of evoked electromyographic (EMG) activation of the facial nerve for intraoperative monitoring of the electrode insertion during cochlear implantation (CI). Intraoperative EMG measurements from the facial nerve were conducted in nine patients undergoing CI implantation. Electric current pulses were emitted from contacts on the CI array during and immediately after electrode insertion. For control, the results of EMG measurements were compared to postoperative flat panel volume computed tomography scans with secondary reconstruction (fpVCTSECO). During insertion, the EMG response evoked by the electrical stimulation from the CI was growing with the stimulating contact approaching the facial nerve and declined with increasing distance. After full insertion, contacts on the apical half of the CI array stimulated higher EMG responses compared with those on the basal half. Comparison with postoperative imaging demonstrated that electrode contacts stimulating high EMG responses had the shortest distances to the facial nerve. It could be demonstrated that electrically evoked EMG activation of the facial nerve can be used to monitor the progress during CI electrode insertion and to control the intracochlear electrode position after full insertion.
Gender dysphoria in twins: a register-based population study
Authors: Karamanis Georgios , Karalexi Maria , White Richard , Frisell Thomas , Isaksson Johan , Skalkidou Alkistis , Papadopoulos Fotios C. 
Published: August 2022

AbstractBoth genetic and environmental influences have been proposed to contribute to the variance of gender identity and development of gender dysphoria (GD), but the magnitude of the effect of each component remains unclear. We aimed to examine the prevalence of GD among twins and non-twin siblings of individuals with GD, using data derived from a large register-based population in Sweden over the period 2001–2016. Register data was collected from the Statistics Sweden and the National Board of Health and Welfare. The outcome of interest was defined as at least four diagnoses of GD or at least one diagnosis followed by gender-affirming treatment. A total of 2592 full siblings to GD cases were registered, of which 67 were twins; age at first GD diagnosis for the probands ranged from 11.2 to 64.2 years. No same-sex twins that both presented with GD were identified during the study period. The proportion of different-sex twins both presenting with GD (37%) was higher than that in same-sex twins (0%, Fisher’s exact test p-value < 0.001) and in non-twin sibling pairs (0.16%). The present findings suggest that familial factors, mainly confined to shared environmental influences during the intrauterine period, seem to contribute to the development of GD.
Anatomic measurement of osseous parameters of the glenoid
Authors: Zhou Jing , Zhong Bin , Qu Rongmei , Qian Lei , Li Zeyu , Liu Chang , Xiao Zhaoming , Xu Guangwei , Liang Haibin , Wei Kuanhai , Ouyang Jun , Dai Jingxing 
Published: August 2022

AbstractThe angle and position of the scapular glenoid are important in shoulder mechanics, the interpretation of diseases, and planning shoulder replacement surgery. In total shoulder replacement, understanding the bony parameters of the glenoid is also of considerable guiding significance for designing implant size and improving material adaptability. To compare glenoid parameters measured from skeletal scapula specimens with those measured by 3D modeling of CT scanning images, analyze correlations between these data, and draw conclusions to guide clinical treatment of shoulder joint injury and total shoulder joint replacement. The data of manual and CT measurements from the same Chinese dry glenoid was compared. Three-dimensional measurement data were collected from the Japanese population and compared with the Chinese population data generated in this study. There were no significant differences between manual measurement and CT measurement in the inclination angle, glenopolar angle, anteroposterior transverse diameter, upper to lower vertical diameter, and depth of the glenoid (P = 0.288, 0.524, 0.111, 0.194, and 0.055, respectively). Further, there were no significant differences between Japanese and Chinese glenoid bones in the upper and lower vertical diameters or anteroposterior transverse diameters (P > 0.05). There were no significant differences between CT and manual measurements, suggesting that the CT method may provide measurements very close to the actual specimen size. This result, however, indicated that the measurer should be careful when measuring the depth of the glenoid.
Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer
Authors: Kim Namjoo , Gim Jeong-An , Lee Beom Jae , Choi Byung il , Yoon Hee Sook , Kim Seung Han , Joo Moon Kyung , Park Jong-Jae , Kim Chungyeul 
Published: August 2022

AbstractVarious omics-based biomarkers related to the occurrence, progression, and prognosis of colorectal cancer (CRC) have been identified. In this study, we attempted to identify gut microbiome-based biomarkers and detect their association with host gene expression in the initiation and progression of CRC by integrating analysis of the gut mucosal metagenome, RNA sequencing, and sociomedical factors. We performed metagenome and RNA sequencing on colonic mucosa samples from 13 patients with advanced CRC (ACRC), 10 patients with high-risk adenoma (HRA), and 7 normal control (NC) individuals. All participants completed a questionnaire on sociomedical factors. The interaction and correlation between changes in the microbiome and gene expression were assessed using bioinformatic analysis. When comparing HRA and NC samples, which can be considered to represent the process of tumor initiation, 28 genes and five microbiome species were analyzed with correlation plots. When comparing ACRC and HRA samples, which can be considered to represent the progression of CRC, seven bacterial species and 21 genes were analyzed. When comparing ACRC and NC samples, 16 genes and five bacterial species were analyzed, and four correlation plots were generated. A network visualizing the relationship between bacterial and host gene expression in the initiation and progression of CRC indicated that Clostridium spiroforme and Tyzzerella nexilis were hub bacteria in the development and progression of CRC. Our study revealed the interactions of and correlation between the colonic mucosal microbiome and host gene expression to identify potential roles of the microbiome in the initiation and progression of CRC. Our results provide gut microbiome-based biomarkers that may be potential diagnostic markers and therapeutic targets in patients with CRC.
The chromosome-scale genome sequence of Triadica sebifera provides insight into fatty acids and anthocyanin biosynthesis
Authors: Luo Jie , Ren Wenyu , Cai Guanghua , Huang Liyu , Shen Xin , Li Na , Nie Chaoren , Li Yingang , Wang Nian 
Published: August 2022

AbstractThe Chinese tallow tree (Triadica sebifera) can produce oil with high content of unsaturated fatty acids in seeds and shows attractive leaf color in autumn and winter. Here, the 739 Mb chromosome-scale genome sequence of the Chinese tallow tree was assembled and it reveals the Chinese tallow tree is a tetraploid. Numerous genes related to nutrition assimilation, energy utilization, biosynthesis of secondary metabolites and resistance significantly expanded or are specific to the Chinese tallow tree. These genes would enable the Chinese tallow tree to obtain high adaptability. More genes in fatty acids biosynthesis in its genome, especially for unsaturated fatty acids biosynthesis, and higher expression of these genes in seeds would be attributed to its high content of unsaturated fatty acids. Cyanidin 3-O-glucoside was identified as the major component of anthocyanin in red leaves. All structural genes in anthocyanin biosynthesis show significantly higher expression in red leaves than in green leaves. Transcription factors, seven MYB and one bHLH, were predicted to regulate these anthocyanin biosynthesis genes. Collectively, we provided insight into the polyploidization, high adaptability and biosynthesis of the high content of unsaturated fatty acids in seeds and anthocyanin in leaves for the Chinese tallow tree.
Sample illumination device facilitates in situ light-coupled NMR spectroscopy without fibre optics
Authors: Bramham Jack E. , Golovanov Alexander P. 
Published: August 2022

AbstractIn situ illumination of liquid-state nuclear magnetic resonance (NMR) samples makes it possible for a wide range of light-dependent chemical and biological phenomena to be studied by the powerful analytical technique. However, the position of an NMR sample deep within the bore of the spectrometer magnet renders such illumination challenging. Here, we demonstrate the working principles of a sample illumination device (NMRtorch) where a lighthead containing an LED array is positioned directly at the top of an NMRtorch tube which is inserted into the NMR spectrometer. The wall of the tube itself acts as a light guide, illuminating the sample from the outside. We explore how this new setup performs in a number of photo-NMR applications, including photoisomerisation and photo-chemically induced dynamic nuclear polarisation (photo-CIDNP), and demonstrate the potential for ultraviolet (UV) degradation studies with continuous online NMR assessment. This setup enables users of any typical liquid-state spectrometer to easily perform in situ photo-NMR experiments, using a wide range of wavelengths.
A synoptic bridge linking sea salt aerosol concentrations in East Antarctic snowfall to Australian rainfall
Authors: Udy Danielle G. , Vance Tessa R. , Kiem Anthony S. , Holbrook Neil J. 
Published: August 2022

AbstractPrevious research has shown that aerosol sea salt concentrations (Southern Ocean wind proxy) preserved in the Law Dome ice core (East Antarctica) correlate significantly with subtropical eastern Australian rainfall. However, physical mechanisms underpinning this connection have not been established. Here we use synoptic typing to show that an atmospheric bridge links East Antarctica to subtropical eastern Australia. Increased ice core sea salt concentrations and wetter conditions in eastern Australia are associated with a regional, asymmetric contraction of the mid-latitude westerlies. Decreased ice core sea salt concentrations and drier eastern Australia conditions are associated with an equatorward shift in the mid-latitude westerlies, suggesting greater broad-scale control of eastern Australia climate by southern hemisphere variability than previously assumed. This relationship explains double the rainfall variance compared to El Niño-Southern Oscillation during late spring-summer, highlighting the importance of the Law Dome ice core record as a 2000-year proxy of eastern Australia rainfall variability.
Cultural Adaptation of Parent-Implemented Early Communication Interventions: A Scoping Review
Authors: Albin Maya , Micsinszki Samantha , Phoenix Michelle 
Published: August 2022

Purpose:
Parent-implemented early communication interventions are commonly delivered to culturally and linguistically diverse families. Although there is evidence from fields such as public health or psychology, there is little guidance regarding what elements to culturally adapt for parent-implemented speech-language pathology interventions. This scoping review addresses this gap by identifying parent-implemented early communication interventions that have been culturally adapted and describing which intervention components were adapted. Definitions of culture, use of adaptation frameworks, and adaptation guidelines, policies, and recommendations are also reported.

Method:
The databases Cumulative Index to Nursing and Allied Health Literature, MEDLINE, PsycINFO, and Embase via OVID were searched. Supplementary search methods, including hand-searching of references and a gray literature search, were also conducted. Covidence software was used to deduplicate, collate, and review articles. Population, intervention, study, and cultural adaptation data were extracted and synthesized using the Ecological Validity Framework.

Results:
Twenty-one articles were included from the database and supplementary searches. No studies defined culture, and only three used cultural adaptation models or frameworks to guide adaptation. Studies varied greatly in what they adapted; language adaptations, such as translation, were conducted most frequently, and intervention goals were rarely adapted. Only three studies obtained parent feedback to inform cultural adaptation for future recommendations.

Conclusions:
More clarity in the reporting of cultural adaptation for communication interventions is required. Cultural adaptation frameworks are useful tools to guide adaptation but can be difficult to operationalize. Additional research in this area is necessary to help clinicians provide culturally responsive, parent-implemented communication interventions.

Supplemental Material:

https://doi.org/10.23641/asha.20416107
Interpretation and Use of Standardized Language Assessments for Diverse School-Age Individuals
Authors: Girolamo Teresa , Ghali Samantha , Campos Ivan , Ford Andrea 
Published: August 2022

Purpose:

The ultimate aim of an assessment is to help examiners make valid conclusions about an individual's skill given their performance on a particular measure. However, assessing the language abilities of culturally and linguistically diverse (CLD) individuals requires researchers and practitioners to carefully consider the appropriateness of traditional parameters of test psychometrics (e.g., reliability, or consistency of assessments as measurement)
plus
the intersectional identities that inform the generalizability of these parameters. The purpose of this clinical focus article is to provide clinicians and researchers with resources to interpret and use common standardized language assessments in English for CLD school-age youth. We present theories from psychometrics, legal studies, and education relevant to language assessment of diverse individuals, review standardized language assessments in English, and provide theory-to-practice applications of language assessment scenarios.

Conclusions:
Implementing intersectional approaches in working with diverse children and using assessment scores as just one piece of evidence amid a broader evidence base will contribute to a more accurate evaluation of CLD children's language abilities. A comprehensive approach involving multiple stakeholders across the field of communication sciences and disorders may support achieving such implementation.
Galaxy morphoto-Z with neural Networks (GaZNets)
Authors: Li Rui , Napolitano Nicola R. , Feng Haicheng , Li Ran , Amaro Valeria , Xie Linghua , Tortora Crescenzo , Bilicki Maciej , Brescia Massimo , Cavuoti Stefano , Radovich Mario 
Published: August 2022

Aims.In the era of large sky surveys, photometric redshifts (photo-z) represent crucial information for galaxy evolution and cosmology studies. In this work, we propose a new machine learning (ML) tool called Galaxy morphoto-Z with neural Networks (GaZNet-1), which uses both images and multi-band photometry measurements to predict galaxy redshifts, with accuracy, precision and outlier fraction superior to standard methods based on photometry only.Methods.As a first application of this tool, we estimate photo-zfor a sample of galaxies in the Kilo-Degree Survey (KiDS). GaZNet-1 is trained and tested on ∼140 000 galaxies collected from KiDS Data Release 4 (DR4), for which spectroscopic redshifts are available from different surveys. This sample is dominated by bright (MAG_AUTO < 21) and low-redshift (z <  0.8) systems; however, we could use ∼6500 galaxies in the range 0.8 <  z <  3 to effectively extend the training to higher redshift. The inputs are ther-band galaxy images plus the nine-band magnitudes and colors from the combined catalogs of optical photometry from KiDS and near-infrared photometry from the VISTA Kilo-degree Infrared survey.Results.By combining the images and catalogs, GaZNet-1 can achieve extremely high precision in normalized median absolute deviation (NMAD = 0.014 for lower redshift and NMAD = 0.041 for higher redshift galaxies) and a low fraction of outliers (0.4% for lower and 1.27% for higher redshift galaxies). Compared to ML codes using only photometry as input, GaZNet-1 also shows a ∼10%−35% improvement in precision at different redshifts and a ∼45% reduction in the fraction of outliers. We finally discuss the finding that, by correctly separating galaxies from stars and active galactic nuclei, the overall photo-zoutlier fraction of galaxies can be cut down to 0.3%.
Osteosynthese bei proximaler Oberarmkopffraktur: Unterfütterung mittels Knochenblock (Bovist) bei der Plattenosteosynthese
Authors: Kralinger Franz , Hengg Clemens 
Published: August 2022

ZusammenfassungFehlende mediale Rekonstruierbarkeit aufgrund von Trümmerzonen bzw. Substanzdefekten nach Varusfrakturen durch das „Aushöhlen des Kopffragmentes“ können kopferhaltend mithilfe eines
Allografts mechanisch stabil versorgt werden. In diesem Artikel wird die Technik mittels „Bovist“ beschrieben. Sie ist unserer Ansicht nach technisch einfacher als die Rekonstruktion mittels
eines Fibula-Allografts und bietet den Vorteil, dass der Schaft für spätere Revisionen nicht langstreckig durch die eingeheilte Fibula verschlossen ist. Der Name leitet sich von der Pilzform
des Knochenblocks ab, der sich im proximalen Schaft selbst verankert und das Kopffragment ruht mechanisch stabil auf seinem „Schirm“. Der Artikel fokussiert sich auf die operative Technik
und liefert die relevante Literatur.
Frakturprothetik an der Schulter - nur noch invers?
Authors: Plecko Michael , Schwarz Angelika 
Published: August 2022

ZusammenfassungFrakturen am proximalen Humerus sind häufige Verletzungen und ihre Behandlung stellt insbesondere bei alten Patient*innen mit erheblicher Osteoporose weiterhin eine große Herausforderung
dar. In den letzten 10 Jahren hat neben der konservativen Therapie und der Osteosynthese der Gelenkersatz mittels inverser Schultertotalendoprothese in der Frakturbehandlung stark an
Bedeutung gewonnen. Eine im Vergleich zur Hemiprothese einfachere Operationstechnik und der Umstand, dass ein Einheilen der Tubercula zwar erstrebenswert, im Gegensatz zur Hemiprothese für
eine brauchbare Funktion jedoch nicht zwingend notwendig ist, haben in manchen Abteilungen dazu geführt, dass die inverse Schultertotalendoprothese die Hemiprothese in der Frakturbehandlung
völlig verdrängt hat. Dennoch verbleiben spezielle Fälle, die auch heute noch einer Frakturhemiprothese bedürfen, sodass diese anspruchsvolle Operationstechnik und die wesentlichen Details,
die für ein gutes funktionelles Ergebnis unumgänglich sind, auch weiterhin gepflegt und gelehrt werden müssen. Sowohl für die inverse Schultertotalendoprothese als auch für die
Frakturhemiprothese sind spezielle Frakturdesigns in zementierter Form zu bevorzugen. Weiterhin ist eine möglichst anatomische Einheilung der Tubercula durch eine ausgereifte
Refixationstechnik anzustreben. Beide Prothesentypen haben weiterhin ihren festen Platz im Versorgungsspektrum proximaler Humerusfrakturen, wenngleich sich die Wertigkeiten deutlich
zugunsten der inversen Schultertotalendoprothese verschoben haben.