bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Interplay Between Multisensory Processing and Attention in Working Memory: Behavioral and Neural Indices of Audiovisual Object Storage
Authors: Arslan Ceren , Schneider Daniel , Getzmann Stephan , Wascher Edmund , Klatt Laura‐Isabelle 
Published: February 2025

ABSTRACTAlthough real‐life events are multisensory, how audio‐visual objects are stored in working memory is an open question. At a perceptual level, evidence shows that both top‐down and bottom‐up attentional processes can play a role in multisensory interactions. To understand how attention and multisensory processes interact in working memory, we designed an audiovisual delayed match‐to‐sample task in which participants were presented with one or two audiovisual memory items, followed by an audiovisual probe. In different blocks, participants were instructed to either (a) attend to the auditory features, (b) attend to the visual features, or (c) attend to both auditory and visual features. Participants were instructed to indicate whether the task‐relevant features of the probe matched one of the task‐relevant feature(s) or objects in working memory. Behavioral results showed interference from task‐irrelevant features, suggesting bottom‐up integration of audiovisual features and their automatic encoding into working memory, irrespective of task relevance. Yet, event‐related potential analyses revealed no evidence for active maintenance of these task‐irrelevant features, while they clearly taxed greater attentional resources during recall. Notably, alpha oscillatory activity revealed that linking information between auditory and visual modalities required more attentional demands at retrieval. Overall, these results offer critical insights into how and at which processing stage multisensory interactions occur in working memory.
Who Suffers the Most From the Cost of Living Crisis?
Authors: Lokshin Michael , Sajaia Zurab , Torre Iván 
Published: February 2025

ABSTRACTThis paper constructs household‐specific Laspeyres indexes for different groups of households to quantify the differences in the distribution of the burden of high inflation among the populations of countries in Europe and Central Asia. The analysis demonstrates that the cost of living crisis of 2022–23 has had a heterogeneous impact on European populations. Poor households appear to suffer the most from rising food and energy prices. Poverty and inequality rates, as well as the profiles of the poor based on household‐specific inflation rates, systematically differ from those based on the standard consumer price index measure of inflation.
Cleavable donor‐assisted CRISPR/Cas9 system significantly improves the efficiency of large DNA insertion in Physcomitrium patens
Authors: Gu Xinyuan , Lang Jintao , Chang Ying , Zhang Min 
Published: February 2025

SUMMARYPrecise insertion of desired fragments can be achieved by CRISPR/Cas9‐based genome editing. However, a decrease in knock‐in efficiency has been observed with increasing length of exogenous inserts. In this study, we developed an in vivo cleavable (IVC) donor‐assisted CRISPR/Cas9 system to improve efficiency, particularly for larger inserts, in the moss Physcomitrium patens (P. patens). The IVC donor, which contains two Cas9 nuclease recognition sites flanking the homology template, enables the in vivo release of the linear template for homology‐directed repair (HDR) when co‐delivered with the corresponding CRISPR/Cas9 plasmid into protoplasts. In our experimental framework, two distinct sgRNAs and four different DNA inserts were evaluated. Compared with standard circular donors, IVC donors significantly enhanced the efficiency of CRISPR/Cas9‐mediated precise insertion of 5.8, 7.5, and 11.1 kb DNA fragments at the PpPDV2‐4 sgRNA target site, improving integration rates from 29.6 to 67.8%, from 15.0 to 72.0%, and from 12.1 to 65.6%, respectively. At an alternative sgRNA2 target site within the Pp6c18_3160 locus, the IVC donor also demonstrated a higher knock‐in efficiency for a 7.4 kb fragment compared with the standard circular donor. This IVC donor‐assisted CRISPR/Cas9 approach for large fragment knock‐in represents a powerful tool for basic research and synthetic biology efforts in moss species. Moreover, this strategy may be potentially applicable to crops that are amenable to protoplast transformation and regeneration, facilitating the improvement of key traits.
To infinity and beyond: recent progress, bottlenecks, and potential of clonal seeds by apomixis
Authors: Heidemann Bas , Primetis Elias , Zahn Iris E. , Underwood Charles J. 
Published: February 2025

SUMMARYApomixis – clonal seed production in plants – is a rare yet phylogenetically widespread trait that has recurrently evolved in plants to fix hybrid genotypes over generations. Apomixis is absent from major crop species and has been seen as a holy grail of plant breeding due to its potential to propagate hybrid vigor in perpetuity. Here we exhaustively review recent progress, bottlenecks, and potential in the individual components of gametophytic apomixis (avoidance of meiosis, skipping fertilization by parthenogenesis, autonomous endosperm development), and sporophytic apomixis. The Mitosis instead of Meiosis system has now been successfully set up in three species (Arabidopsis, rice, and tomato), yet significant hurdles remain for universal bioengineering of clonal gametes. Parthenogenesis has been engineered in even more species, yet incomplete penetrance still remains an issue; we discuss the choice of parthenogenesis genes (BABY BOOM, PARTHENOGENESIS, WUSCHEL) and also how to drive egg cell‐specific expression. The identification of pathways to engineer autonomous endosperm development would allow fully autonomous seed production, yet here significant challenges remain. The recent achievements in the engineering of synthetic apomixis in rice at high penetrance show great potential and the remaining obstacles toward implementation in this crop are addressed. Overall, the recent practical examples of synthetic apomixis suggest the field is flourishing and implementation in agricultural systems could soon take place.
Picone Identities of a Certain Class of Conformable Half Linear Anisotropic Biharmonic Equations
Authors: Sundaravadivel Priyadharshini , Vadivel Sadhasivam , Kodakkal Kannan Viswanathan , Duraisamy Sambasivam Sankar 
Published: February 2025

Main aim of this article, we derive sufficient conditions of new results for Picone identities for a certain class of conformable half-linear anisotropic biharmonic equations. We derive a Strumiancomparison theorem and oscillation results. Furthermore, the oscillation results are different from the most known ones in the sense that they are based on the information for radial solutions. This paper's expand upon and broaden a few of the previously established results for conformable half-linear anisotropic biharmonic equations. If and then conformable half-linear anisotropic biharmonic equations (4) become the classical biharmonic equation. These novel outcomes add to the body of knowledge already available in the classical example. To illustrate the usefulness of our new results, we give an example.
Existence of weak solutions and long‐time asymptotics for hydrodynamic model of swarming
Authors: Chaudhuri Nilasis , Choi Young‐Pil , Tse Oliver , Zatorska Ewelina 
Published: February 2025

AbstractWe consider a one‐dimensional hydrodynamic model featuring nonlocal attraction–repulsion interactions and singular velocity alignment. We introduce a two‐velocity reformulation and the corresponding energy‐type inequality, in the spirit of the Bresch–Desjardins estimate. We identify a dependence between the communication weight and interaction kernel and between the pressure and viscosity term allowing for this inequality to be uniform in time. It is then used to study long‐time asymptotics of solutions.
Loser Language: Examining National Basketball Association Players’ Image-Repair Strategies Following a Loss
Authors: Hoffman Robert , Corr Chris , Atwater Christopher , Fanelli Sabrina 
Published: February 2025

While the vast majority of image-repair research in sport settings focuses on individual deviancy, recent scholarship has called for the examination of image-repair strategies following competition losses. Utilizing extant theoretical tenets of image repair, this mixed-method study sought to measure and analyze the image-repair strategies used by National Basketball Association (NBA) players following losses during 2022 and 2023 postseason competition. Analysis revealed that NBA players on teams that lost frequently employed strategies of corrective action, deference, bolstering, mortification, and defeasibility. In addition, the individual statistical performances of NBA players had no significant impact on the use of image-repair strategies. The findings of this study suggest that teams and athletes treat losing as a significant crisis, resorting to small sets of mostly accommodating styles of image repair. Implications for both academicians and practitioners are discussed.
Minimal Influence of Formulated Nutritional Interventions on Sleep and Next-Morning Physical Performance, Cognitive Function, and Postural Sway in Adult Males: A Randomized, Placebo-Controlled, Crossover Study
Authors: Morrison Matthew , Weakley Jonathon , Roach Gregory D. , Sargent Charli , Miller Dean J. , Nyman Lara , Gardiner Carissa , Munteanu Gabriella , Pahnke Matthew D. , Halson Shona L. 
Published: February 2025

Athletes often experience poor sleep quality and quantity which may hinder physical performance and cognitive function. Presleep nutritional strategies may be an alternative to pharmacological interventions to improve sleep. The aim of this study was to examine the effect of two different doses of a nutritional intervention (both containing high Glycemic Index carbohydrate, whey, tryptophan, theanine, and 5′AMP) versus placebo on objective and subjective sleep, next-morning physical performance, cognitive function, and postural sway. Seventeen healthy, trained adult males completed three double-blind trials in a randomized, counterbalanced, crossover design. Participants were allocated to conditions using a Latin Square design. A (a) low-dose, (b) high-dose, or (c) placebo drink was provided 90 min before sleep each night. Polysomnography was used to measure objective sleep parameters. Cognitive function, postural sway, and subjective sleep quality were assessed 30 min after waking. Physical performance was assessed using a 10-min maximal effort cycling time trial each morning. All data were analyzed using linear mixed effects models and effect sizes were calculated using Cohen’s d. This study was registered prospectively as a clinical trial with Australian New Zealand Clinical Trials Registry (registration number: NCT05032729). No significant main effects or improvements were observed in objective or subjective sleep parameters, physical performance, cognitive function, or postural sway. The low-dose intervention appeared to reduce N3 sleep duration compared with placebo (−13.6 min). The high-dose intervention appeared to increase N1 sleep duration compared with placebo (+7.4 min). However, the magnitude of changes observed were not likely to cause meaningful reductions in sleep quality and quantity.
Menstrual Phase and Postmatch Perceptual Recovery Responses for Naturally Menstruating Football Players
Authors: Brown Georgia A. , Fullagar Hugh H.K. , Duffield Rob 
Published: February 2025

Purpose: To explore the influence of menstrual phase on postmatch perceptual responses and the time course of recovery for professional footballers. Methods: Thirteen naturally menstruating footballers tracked their menstrual cycle and reported perceptual responses for up to 4 cycles. Menstrual phases were determined by calendar-based tracking and urinary hormone tests and classified as menstruation, follicular, or luteal. On match days (MDs) and the following 2 days (MD+1 and MD+2), players completed perceptual questionnaires on fatigue, soreness, stress, sleep, and perceived recovery status (PRS). Total high-speed running distance during matches was recorded using GPS devices to represent load. Data were analyzed using linear mixed models. Results: Day × total high-speed running distance affected PRS (P < .001), total wellness (P < .001), fatigue (P = .047), soreness (P < .001), and stress (P = .044). Significant main effects were found for menstrual phase on PRS (P = .038), Day on stress (P = .034), and total high-speed running distance on soreness (P = .045). During the menstruation phase, moderate effect sizes (ES) existed for worse PRS on MD and MD+2 (P = .07–.28, ES > 0.51) and better sleep quality on MD+2 (P = .13, ES = 0.56). No significant differences between menstrual phases existed (P > .05), and all other ESs were trivial to small (ES < 0.50). All perceptual measures, except stress, differed significantly between days (P < .05), with differences based on match load and, to a lesser extent, menstrual phase. Conclusion: PRS may be worse during menstruation, although menstrual phase has limited association with postmatch perceptual responses. Variability in the recovery time course for perceptual measures exists between menstrual phases, but evidence for consistently impaired recovery time course in any phase was not evident.
Tackling cutaneous herpes simplex virus disease with topical immunomodulators—a call to action
Authors: Duarte Luisa F. , Carbone-Schellman Javier , Bueno Susan M. , Kalergis Alexis M. , Riedel Claudia A. , González Pablo A. 
Published: February 2025

SUMMARY
Antivirals play important roles in restricting viral diseases. Nevertheless, they act on a relatively limited number of viruses and occasionally display partial effectiveness in some tissues or against escape variants. Although vaccination remains the most cost-effective approach for preventing microbial diseases, developing prophylactic or therapeutic solutions for pathogens, such as herpes simplex viruses (HSVs), that effectively reduce their clinical manifestations in the skin has proven exceptionally challenging despite extensive research. Alternatively, a less explored approach for tackling HSV skin infection involves using topical immunomodulatory molecules to potentiate the host’s innate antiviral immune responses. When applied directly to herpetic skin lesions where viral antigen is present, this strategy has the potential to elicit virus-specific adaptive immunity. Based on currently available data, we foresee substantial potential for this approach in addressing HSV skin infections, along with additional prospects to advance understanding of skin biology and apply relevant new findings to other dermatological conditions. However, due to the limited number of case studies evaluating this method and its safety profile, particularly in immunocompromised individuals and pregnant women, further research is crucial, especially to assess the effects of immunomodulators in these vulnerable populations. Here, we revisit and discuss the use of immunomodulatory molecules for potentiating the host immune response against HSV skin infection and call for action for increased research and clinical trials regarding the possible benefits of this latter strategy for treating HSV cutaneous disease and recurrences. We also revisit and discuss antivirals and vaccine candidates against HSVs.
Ethanol inhibits the growth and metastasis of hepatocellular carcinoma by inducing immunogenic cell death
Authors: Hsu Yu-Chen , Wu Meng-Chuan , Weng Meng Tzu , Lee Ying-Te , Chou Huei-Chi , Lee Hsuan-Shu , Wang Li-Fang , Sheu Jin-Chuan , Chen Chien-Hung 
Published: February 2025

BackgroundImmunogenic cell death (ICD) can elicit an adaptive immune response with significant antitumor effects. Percutaneous ethanol injection therapy has been applied as tumor ablation for small hepatocellular carcinoma (HCC). However, it was not clear whether ethanol can elicit ICD. The aim of this study is to investigate the role of ethanol as an ICD inducer.MethodsHCC cell lines were treated with low-concentration ethanol and ICD markers, such as calreticulin, high-mobility group box 1, and ATP were assayed. The mouse vaccination-rechallenge assay was used to further confirm ethanol as an ICD inducer. Western blot and real-time PCR were used to investigate ICD-related endoplasmic reticulum (ER) stress and signaling pathways. The genes with differential expression levels between primary and distant tumors were analyzed by nCounter gene expression. Intratumoral injection of ethanol was done to investigate the abscopal effect.ResultsThe low-concentration ethanol could induce ICD in HCC cell lines through unfolded protein responses initiated by ER stress and multiple cell-death pathways. Intratumoral injections of low-concentration ethanol had significantly direct and abscopal antitumor effects in mouse models of both subcutaneous and orthotopic HCC. nCounter gene expression analysis in primary and distant tumors revealed the activation of various immune-response pathways, notably those mediated by CD8 T cells and the interferon pathway. Vaccinating mice with low-concentration ethanol-treated HCC cells successfully inhibited metastasis in both intravenous and intrasplenic metastasis models.ConclusionsOur results suggest that low-concentration ethanol could serve as an inducer of ICD. Low-concentration ethanol could potentially improve therapeutic antitumor immunity by inducing substantial ICD.
Clinical outcomes after stenting treatment in patients with idiopathic intracranial hypertension and intrinsic versus extrinsic venous sinus stenosis
Authors: Tong Xu , Guan Zhongao , Li Xiaoqing , Wang Shuran , Song Shuang , Gan Yawen , Chen Fangguang , He Jie , Tu Ketao , Yu Zhenfei , Mo Dapeng 
Published: February 2025

BackgroundEndovascular stenting is a promising treatment for patients with idiopathic intracranial hypertension (IIH) and venous sinus stenosis (VSS). However, data on the impact of stenosis type on clinical outcomes of patients undergoing stenting treatment remain limited. This prospective cohort study aimed to compare post-stenting outcomes in patients with IIH and intrinsic versus extrinsic VSS.MethodsPatients with IIH and VSS undergoing stenting at a tertiary hospital in China were enrolled consecutively from 2017 to 2023. Based on digital subtraction angiography, high-resolution MRI, and intravascular ultrasound findings, patients were categorized into two groups: intrinsic or extrinsic stenosis. At 6 months post-stenting, clinical outcomes including cerebrospinal fluid (CSF) pressure, headache, visual impairment, and papilledema were recorded. Multivariable regression models were used to explore the relationship between stenosis type and clinical outcomes.ResultsIn total, 92 patients were included, 60 with intrinsic stenosis and 32 with extrinsic stenosis. At 6 months, the intrinsic group had lower CSF pressure (median 180 vs 210 mmH2O, β coefficient −31.8, 95% CI −54.0 to −9.6) and a higher rate of complete symptom resolution (81.7% vs 40.6%, OR 8.88, 95% CI 2.60 to 30.30) than the extrinsic group. Additionally, 36.8% (95% CI 10.5% to 77.2%) of the effect of stenosis type on complete symptom resolution at 6 months was mediated through reduction in CSF pressure.ConclusionThis single-center study suggested that patients with IIH and intrinsic VSS had lower CSF pressure and better symptom recovery compared with those with extrinsic VSS at 6 months post-stenting. Further validation in other centers and populations is needed.Trial registration numberChiCTR.org.cn, ChiCTR-ONN-17010421.
Weakly supervised veracity classification with LLM-predicted credibility signals
Authors: Leite João A. , Razuvayevskaya Olesya , Bontcheva Kalina , Scarton Carolina 
Published: February 2025

Abstract
Credibility signals represent a wide range of heuristics typically used by journalists and fact-checkers to assess the veracity of online content. Automating the extraction of credibility signals presents significant challenges due to the necessity of training high-accuracy, signal-specific extractors, coupled with the lack of sufficiently large annotated datasets. This paper introduces Pastel (Prompted weAk Supervision wiTh crEdibility signaLs), a weakly supervised approach that leverages large language models (LLMs) to extract credibility signals from web content, and subsequently combines them to predict the veracity of content without relying on human supervision. We validate our approach using four article-level misinformation detection datasets, demonstrating that Pastel outperforms zero-shot veracity detection by 38.3% and achieves 86.7% of the performance of the state-of-the-art system trained with human supervision. Moreover, in cross-domain settings where training and testing datasets originate from different domains, Pastel significantly outperforms the state-of-the-art supervised model by 63%. We further study the association between credibility signals and veracity, and perform an ablation study showing the impact of each signal on model performance. Our findings reveal that 12 out of the 19 proposed signals exhibit strong associations with veracity across all datasets, while some signals show domain-specific strengths.
The North Chukchi – Podvodnikov and the Zhokhov – Wrangel Composite Tectono-Sedimentary Elements, East Siberian Arctic
Authors: Drachev Sergey S. , Houseknecht David W. 
Published: February 2025

North Chukchi-Podvodnikov (NChP) and Zhokhov-Wrangel (ZhW) composite tectono-sedimentary elements (CTSEs) occupy the northern parts of East Siberian Sea, and Russia and United States Chukchi Sea, and adjacent part of the deep-water Podvodnikov and Toll basins of the Arctic Ocean. The NChP CTSE formed as a rift basin and includes one of the largest depocentres in the Arctic, the North Chukchi Basin. It contains a 23-km-thick succession of presumably Cretaceous and Cenozoic deposits, which may be underlain by either exhumed mantle or by incipient oceanic crust. Long-offset multichannel seismic profiles and seismic refraction data allow for many details of the basin's geology to be imaged.
The ZhW CTSE is located in the front of Late Mesozoic New Siberian-Chukchi Fold-and-Thrust Belt. In Cretaceous and Cenozoic, it was dissected both by late contractional deformation and by succeeding extension probably related to the boundary between Eurasian and North American lithospheric plates.
In this chapter we summarise geology of the North Chukchi – Podvodnikov and Zhokhov – Wrangel CTSEs and propose a stratigraphic model based on seismic data calibrated with the drilled stratigraphy of the US Chukchi Sea. We also briefly speculate on possible hydrocarbon plays and systems based on an analogy with Arctic Alaska.