bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOTAL PHENOLICS, ANTIOXIDATIVE AND ANTIMICROBIAL ACTIVITY OF METHANOL EXTRACTS OF BERRIES OF SYMPHORICARPOS ALBUS (L.) S.F.BLAKE, S. × CHENAULTII REHDER AND S. ORBICULATUS MOENCH
Authors: Pustahija Fatima , Subašić Mirel , Mulić Mirnesa , Bašić Neđad 
Published: January 2022

581.19:547.56]:582.971.1
Methanol extracts obtained from the berries of three Symphoricarpos taxa (Caprifoliaceae) were used to determine their total phenols concentrations, and antioxidant and antimicrobial activities. According to our knowledge, total concentrations of phenolic compounds and antimicrobial activities for of S. × chenaultii and S. orbiculatus, as well as antioxidant activity of all three analyzed taxa are for the first time analyzed in this study. Based on obtained results, it was noticed that the highest average values of the total phenols, flavonoids and flavanols had methanol extracts of S. orbiculatus berries (3.525 mg GAE g-1 DW, and 11.037 and 0.881 mg CE g-1 DW, respectively), while methanol extracts of S. albus berries had the lowest (1.430 mg GAE g-1 DW, and 4.154 and 0.211 mg CE g-1 DW respectively). Symphoricarpos orbiculatus extract (IC50 = 5.299 mg mL-1) possessed the highest antioxidant activity while the lowest had S. albus (IC50 = 20.017 mg mL-1). The methanol extracts of analyzed Symphoricarpos taxa showed no antifungal activity against C. albicans. Moderate antibacterial activity of S. albus methanol extract is determined against five tested bacterial strains (Bacillus vulgatus, Enterococcus faecalis, Pseudomonas aeruginosa, Salmonella abony, and Staphylococcus aureus), and S. × chenaultii extract showed a low antibacterial activity only against P. aeruginosa, B. vulgatus and S. aureus. Although S. orbiculatus methanolic extract had the highest antioxidant activity it did not show any antibacterial activity at all. Analyzed Symphoricarpos extracts are potentially effective and can be used as natural antioxidant and antimicrobial preparations against test microorganisms.
Analisis Kepuasan Konsumen Terhadap Kualitas Pelayanan Di Warung Steak On You Kota Baru Jambi
Authors: Khoiria Siti Nur , Anwar US Kasful 
Published: January 2022

Penelitian ini berfokus pada kualitas pelayanan berdasarkan kepuasan pelanggan terhadap Warung Steak On You di Kota Jambi. Tujuan penelitian ini mengetahui dan mengevaluasi tentang kepuasan konsumen terhadap pelayanan yang diberikan oleh Warung Steak On You sebagai tempat makan yang banyak digemari masyarakat Kota Jambi khususnya para remaja. Metode yang digunakan adalah metode Analisis Deskriptif Kualitatif dan metode ServQual. Metode ServQual ini terdiri dari penilaian terhadap beberapa dimensi yaitu: Reliability (Kehandalan), Responsiveness (Daya Tanggap), Assurance (Jaminan), Empathy (Empati) dan Tangible (Bukti Fisik). Penilaian dalam pengumpulan data dilakukan dengan observasi lingkungan sekitar Warung Steak On You dan wawancara langsung terhadap konsumen Warung Steak On You sebagai responden penelitiannya. Hasil yang diperoleh dalam penelitian ini adalah kualitas pelayanan yang diberikan memiliki pengaruh yang signifikan terhadap kepuasan konsumen. Hasil dari penelitian juga mendapatkan hasil bahwa para konsumen dinilai puas dengan pelayanan yang diberikan oleh Warung Steak On You. Hal ini dapat menjadi evaluasi tentang efektifitas kualitas pelayanan yang diberikan kepada konsumen.
Assessing the understandability, actionability, and quality of online resources for the self-management of bipolar disorder
Authors: Sutera Nathan D. , Iuppa Courtney A. , Nelson Leigh Anne , Kriz Carrie R. , Gramlich Nicole A. , Lang Shelby E. , Elliott Ellie S. R. , Sommi Roger W. 
Published: January 2022

Abstract

Introduction
This study aims to assess the understandability, actionability, and quality of online resources for the self-management (SM) of bipolar spectrum disorders in adults.

Methods
An online search using Google, Bing, and Yahoo! search engines was conducted to identify resources for bipolar disorder. Those that were published in English, discussed at least 1 method directed at improving an SM task, and were within the first 25 nonadvertisement results for each search were included. Resources directed specifically at adolescents were excluded. Understandability and actionability of the online resources were evaluated using the Patient Education Materials Assessment Tool (PEMAT). Quality of the online resources was evaluated using the DISCERN instrument. The number of SM tasks each resource discussed was also evaluated. Overall mean appropriateness was calculated by averaging the percentage scores of understandability, actionability, and quality.

Results
Fifty-two resources were included. The mean sample scores were 8.4 (SD, 2.1; range, 2-13; maximum, 15) for understandability, 2.2 (SD, 1.2; range, 0-4; maximum, 5) for actionability, and 46.1 (SD, 8.9; range, 30-57; maximum, 75) for quality. The overall mean appropriateness percentage was 53.5% (SD, 11.7%; range, 18%-77%), with a goal of at least 70%. Included resources addressed a mean of 7.1 tasks (SD, 2.5; range, 1-14; maximum, 20).

Discussion
Most online resources for the SM of bipolar disorder scored poorly for understandability and actionability based on PEMAT scores and had low to moderate scores for quality using the DISCERN instrument. Future online resources should be designed with the goal of increasing appropriateness for patients.
Evaluating the impact of an emergency department protocol that guides management of methamphetamine-induced agitation and psychosis
Authors: Nguyen Julie , Lee Stephen , Ankrah Dennis , Knox Erin 
Published: January 2022

Abstract

Background
Methamphetamine is an addictive stimulant that may induce symptoms of agitation and psychosis. The estimated rate of methamphetamine use is 6.6 per 1000 people. Currently, no treatment guidelines exist to support the optimal management of patients presenting with methamphetamine-induced agitation. Emergency department (ED) providers may prescribe various benzodiazepines (BZDs) and antipsychotics (APs) as first-line agents to stabilize these agitated patients. This study aims to determine the effectiveness of a protocol to guide management of this condition.

Methods
This was a retrospective, pre- and poststudy conducted from July 2020 to March 2021 at a large academic medical center. A multidisciplinary protocol was designed to help manage methamphetamine-induced agitation in the ED. The primary outcome of the study was a reduction in the number of BZDs and APs used for the treatment of methamphetamine-induced agitation. This was measured by the incidence of overprescribing, defined as 3 or more APs or BZDs administered within 30 minutes. Secondary outcomes included the use of physical restraints, ED length of stay, and adverse events.

Results
We did not observe a significantly lower incidence of overprescribing, adverse events, or ED length of stay when comparing pre- and postprotocol groups. A subgroup analysis demonstrated that when protocol was followed, there was a statistically significant reduction in overprescribing (P = .001).

Discussion
We did not find any differences among our primary and secondary outcomes, which may be attributed to protocol nonadherence. Full compliance to the protocol may reduce the rate of overprescribing APs or BZDs in patients with methamphetamine-induced agitation.
Perceptions of clinical pharmacy specialists' contributions in mental health clinical teams
Authors: Gillespie Chris , Kleinberg Felicia , Zogas Anna , Morreale Anthony , Ourth Heather , Tran Michael , Moore Tera , Miller Donald , McCullough Megan 
Published: January 2022

AbstractIntroductionMental health (MH) clinical pharmacy specialists (CPS) are increasingly functioning as integral providers in MH care teams. MH providers may delegate many medication management tasks to the CPS. As there is a shortage of primary care and specialist MH providers, CPS are increasingly being utilized in MH care clinics. We assess provider and CPS perceptions of the contributions of CPS to MH clinical teams in the Veterans Health Administration.MethodsWe examined the roles and functions of CPS in MH clinics through surveys (n = 374) and semistructured interviews (n = 16) with MH CPS and other members of MH clinical teams (psychiatrists, nurse practitioners, registered nurses, social workers) to gain insight into how CPS were integrated in these settings. We assessed perceptions of CPS contributions to MH teams, interactions between CPS and other providers, and challenges of integrating CPS into MH clinical teams.ResultsContributions of CPS in MH were received positively by clinical team members. Clinical pharmacy specialists providing comprehensive medication management were especially valuable in the management of clozapine. The knowledge and training of CPS reassured providers who frequently referred to them with questions about medication and medication therapy management. MH CPS were also perceived to be received well by patients.DiscussionThe integration of MH CPS into MH teams was well received by team members and patients alike. The MH CPS have become important members of the MH team and are widely viewed as being able to improve access, quality, and workflow.
Genetically Encoded Synthetic Beta Cells for Insulin Biosynthesis and Release under Hyperglycemic Conditions
Authors: Liu Jian , Xue Jueyi , Fu Lu , Xu Jiangtao , Lord Megan S. , Liang Kang 
Published: January 2022

AbstractAdvances in artificial/synthetic cells have drawn a new era of nanobiotechnology, which have shown broad prospects in biomedical applications. The rational nanoengineering of synthetic cells that can closely substitute the systematic biological functions of cells is a next grand challenge. Here, a genetically encoded synthetic beta cell, which can sense hyperglycemic conditions to initiate programmed biosynthesis and secretion of insulin is reported. By encapsulating different metal–organic framework‐based artificial organelles with distinctive bifunctionalities, the synthetic cell can undergo programmed, sequential subcellular events, including glucose sensing, initiation of insulin gene transcription and translation, and finally excretion of functional insulin, under hyperglycemic conditions. Glucose uptake assay suggests that the insulin produced by the synthetic cells can successfully promote glucose uptake into mammalian cells. The construction of a higher‐order cell cluster by ligand‐mediated super‐assembly of the synthetic cells is further demonstrated. Such a robust and smart synthetic system that closely mimics the cellular activities of beta cells in response to glucose levels is promising for improving clinical outcomes in diabetes treatment.
SUMOylation in Viral Replication and Antiviral Defense
Authors: Fan Yao , Li Xiang , Zhang Lei , Zong Zhi , Wang Fangwei , Huang Jun , Zeng Linghui , Zhang Chong , Yan Haiyan , Zhang Long , Zhou Fangfang 
Published: January 2022

AbstractSUMOylation is a ubiquitination‐like post‐translational modification that plays an essential role in the regulation of protein function. Recent studies have shown that proteins from both RNA and DNA virus families can be modified by SUMO conjugation, which facilitates viral replication. Viruses can manipulate the entire process of SUMOylation through interplay with the SUMO pathway. By contrast, SUMOylation can eliminate viral infection by regulating host antiviral immune components. A deeper understanding of how SUMOylation regulates viral proteins and cellular antiviral components is necessary for the development of effective antiviral therapies. In the present review, the regulatory mechanism of SUMOylation in viral replication and infection and the antiviral immune response, and the consequences of this regulation for viral replication and engagement with antiviral innate immunity are summarized. The potential therapeutic applications of SUMOylation in diseases caused by viruses are also discussed.
Biochar type and application methods affected nitrogen and phosphorus leaching from a sandy soil amended with inorganic fertilizers and biosolids
Authors: Lu Yanyan , Silveira Maria Lucia , O'Connor George A. , Vendramini Joao M. B. , Li Yuncong C. 
Published: January 2022

AbstractLand application of biochar as a soil amendment can be an effective strategy for reducing nutrient leaching while providing simultaneous benefits to soil health. However, biochar effects on soil nitrogen (N) and phosphorus (P) dynamics in biochar‐amended soils are poorly understood, particularly in Florida sandy soils receiving fertilizers. This study evaluated the effects of different biochar materials (particle size of 0.1 mm produced from pine (Pinus spp.) wood vs. ∼0.5–2 mm produced from fescue (Festuca arundinaceaSchreb.) grass, herein referred as “powder” and “coarse” biochar, respectively) and their application methods (surface vs. incorporated) on N and P leaching from soils amended with inorganic fertilizer or biosolids. Biochar materials were either mixed throughout columns of soil or surface applied at a 1% (w/w) rate. Columns were periodically leached over 6 mo to attain 138 ml (equivalent to ∼1 pore volume) of drainage in each event (total of ∼16 pore volume of leachate). Biochar materials exhibited modest affinity to retain ammonium (NH4+) but showed no ability to sorb nitrate (NO3–). Powder biochar incorporated throughout the soil reduced cumulative NH4–N, NO3–N, and total N mass leached (average of 25% reduction) relative to control (no biochar) treatments. Biochar materials acted as P sources and were ineffective in reducing leachate P. Biosolids generally resulted in significant lower risk of N and P leaching than inorganic fertilizer. Results suggested biochar ability to retain N and P in soils varies with biochar source, application method, and nutrient source. Biochar type and application method affected N and P dynamics in biosolids or inorganic fertilizer‐amended soils, but understanding the mechanisms requires additional study.
Structurally Nontraditional Bipolar Hosts for RGB Phosphorescent OLEDs: Boosted by a “Butterfly‐Shaped” Medium‐Ring Acceptor
Authors: Ma Weixin , Bin Zhengyang , Yang Ge , Liu Junjie , You Jingsong 
Published: January 2022

AbstractThe emitting layer based on a host–guest system plays a crucial role in organic light‐emitting diodes (OLEDs). While emitters have witnessed rapid progress in structural diversity, hosts still rely heavily on traditional structures and are underdeveloped. Herein a “medium‐ring” strategy has been put forward to design structurally nontraditional host molecules, which are not only rotatable enough to suppress close π–π stacking, thus reducing exciton annihilation, but also rigid enough to prevent excessive conformational flipping, thus inhibiting non‐radiative decay. Accordingly, a brand‐new type of bipolar hosts with a twisted “butterfly‐shaped heptagonal acceptor (EtBP), which features an electron‐deficient benzophenone fragment with a flexible ethylidene bridge, has been developed. With satisfactory morphological stability and well‐balanced hole‐ and electron‐transporting properties, the EtBP‐based bipolar hosts enable high‐performance RGB phosphorescent OLEDs with small efficiency roll‐off, which are superior to those of acyclic benzophenone‐based devices.
Gold (I/III)‐Catalyzed Trifluoromethylthiolation and Trifluoromethylselenolation of Organohalides
Authors: Mudshinge Sagar R. , Yang Yuhao , Xu Bo , Hammond Gerald B. , Lu Zhichao 
Published: January 2022

AbstractThe first C−SCF3/SeCF3cross‐coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF3or Me4NSeCF3, and organohalides as substrates are reported. The new methodology enables a one‐stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio‐ and selenoethers with a broad substrate scope (>60 examples with up to 97 % isolated yield). The method is scalable, and its robustness is evidenced by the late‐stage functionalization of various bioactive molecules, which makes this reaction an attractive alternative in the synthesis of trifluoromethylthio‐ and selenoethers for pharmaceutical and agrochemical research and development.
Sol–gel reaction of titanium phosphonate alkoxide cluster
Authors: Tsukagoshi Hayato , Sato Yohei , Yamamoto Kazuki , Hayami Ryohei , Gunji Takahiro 
Published: January 2022

AbstractThe synthesis and properties of titanium phosphonate cluster molecules have been investigated; however, nothing has been done to study not only the catalytic ability of a hydrolyzed cluster but also a behavior of hydrolysis–polycondensation by solvents. The sol–gel reaction of [Ti4(μ3‐O)(OiPr)5(μ‐OiPr)3(O3PPh)3]·thf (Ti4P3Ph) was performed in tetrahydrofuran (THF), toluene, and acetone. The hydrolysis–polycondensation of Ti4P3Ph proceeded in THF and toluene, while Ti4P3Ph in acetone proceeded in two paths (hydrolysis–polycondensation and nonhydrolysis–polycondensation). The hydrolyzed Ti4P3Ph retained its cluster structure, while the calcined Ti4P3Ph at 300°C contained a collapsed cluster structure. The specific surface areas of the hydrolyzed Ti4P3Ph in THF, toluene, and acetone were 154, 302, and 7 m2 g−1, respectively. The photodegradation ability of the hydrolyzed Ti4P3Ph for methylene blue was confirmed by ultraviolet irradiation at 365 nm; however, that of the calcined Ti4P3Ph was not. It was considered that the calcined Ti4P3Ph did not retain its cluster structure. The photocatalytic ability of the hydrolyzed Ti4P3Ph was high in the order of toluene > THF > pristine > acetone. The gels retained cluster structure have higher photocatalytic ability than pristine cluster; however, the gel contained a collapsed cluster structure was found no catalytic ability.
Peroxidase‐like activity of an azamacrocyclic Ni(II) complex
Authors: Cho Jang‐Hoon , Kim Sunghwan , Lee Hong‐In 
Published: January 2022

AbstractPeroxidase‐like activity of an azamacrocyclic Ni(II) complex, [Ni(II)(DMDAC)]2+ (DMDAC = 1,8‐dimethyl‐1,3,6,8,10,13‐hexaaza‐cyclotetradecane = 1,8‐dimethyl diazacyclam), was investigated by observing the oxidation of 2,2′‐azinobis(3‐ethylbenzothiazoline)‐6‐sulfonic acid (ABTS) in the presence of H2O2. UV/Vis and electron paramagnetic resonance spectral changes obtained from the mixture solution of [Ni(II)(DMDAC)](ClO4)2, ABTS, and H2O2 indicated that both ABTS and its oxidized form, ABTS+•, were the substrates of the peroxidase‐like activity of [Ni(II)(DMDAC)]2+. Current work and previously reported experimental and theoretical works on the peroxidase‐like activity of azamacrocyclic Ni(II) complexes suggest that these kind of macrocyclic Ni(II) complexes can generally exhibit peroxidase‐like activity in aqueous solution and the catalytic cycle proceeds through the heterolytic cleavage of the O–OH bond in a Ni(II)‐hydroperoxo species.
Stereoselective Hydrogenation of Platform Molecule α‐Pinene Under Solvent‐Free Conditions
Authors: Fan Haiyan , Zheng Tuo , Liao Xinxi , Sun Mengling , Fu Jile , Zheng Jinbao , Zhang Nuowei , Chen Binghui 
Published: January 2022

AbstractStereoselective hydrogenation of α‐pinene over heterogenous catalysts under solvent‐free conditions is promising for biomass conversion but challenging. Herein, we prepared the Ru‐NiO/Hβ catalysts using chemical reduction and galvanic replacement methods. With the increase of Ni content, the selectivity of cis‐pinane was significantly improved. A high conversion of 100 % and a high cis‐pinane selectivity of 98 % were achieved after 4 h reaction at 80 °C. It has been verified that the addition of Ni can adjust the ratio of Brønsted and Lewis acid, regulate the hydrogen spillover between Ru and support, change the adsorption site of substrate and form steric hindrance effect. All these contribute to the better selectivity of the catalyst. In addition, catalysts presented good stability in the 900 h test.
Sustainable silicon anodes facilitated via a double‐layer interface engineering: Inner SiOx combined with outer nitrogen and boron co‐doped carbon
Authors: Zhou Jun , Lu Yao , Yang Lishan , Zhu Wenqiang , Liu Weifang , Yang Yahui , Liu Kaiyu 
Published: January 2022

AbstractSilicon‐based (Si) materials are promising anodes for lithium‐ion batteries (LIBs) because of their ultrahigh theoretical capacity of 4200 mA h g−1. However, commercial applications of Si anodes have been hindered by their drastic volume variation (∼300%) and low electrical conductivity. Here, to tackle the drawbacks, a hierarchical Si anode with double‐layer coatings of a SiOx inner layer and a nitrogen (N), boron (B) co‐doped carbon (C–NB) outer layer is elaborately designed by copyrolysis of Si–OH structures and a H3BO3‐doped polyaniline polymer on the Si surface. Compared with the pristine Si anodes (7 mA h g−1 at 0.5 A g−1 after 340 cycles and 340 mA h g−1 at 5 A g−1), the modified Si‐based materials (Si@SiOx@C–NB nanospheres) present superior cycling stability (reversible 1301 mA h g−1 at 0.5 A g−1 after 340 cycles) as well as excellent rate capability (690 mA h g−1 at 5 A g−1) when used as anodes in LIBs. The unique double‐layer coating structure, in which the inner amorphous SiOx layer acts as a buffer matrix and the outer defect‐rich carbon enhances the electron diffusion of the whole anode, makes it possible to deliver excellent electrochemical properties. These results indicate that our double‐layer coating strategy is a promising approach not only for the development of sustainable Si anodes but also for the design of multielement‐doped carbon nanomaterials.
Cover crop interseeding effects on aboveground biomass and corn grain yield in western North Dakota
Authors: Antosh Eric , Liebig Mark A. , Archer David W. , Luciano Roberto 
Published: January 2022

Core Ideas
Aboveground biomass was greatest when cover crops were planted at the V4 corn stage.
Aboveground biomass of cover crops was modest (260–608 lb acre−1 yr−1).
Interseeded cover crops did not negatively affect corn grain yield.
Using Fiber Bragg Grating Sensors to Quantify Temperature Non‐Uniformities in Plasmonic Catalyst Beds under Illumination
Authors: Xu Man , den Hartog Tim , Cheng Lun , Wolfs Marciano , Habets Roberto , Rohlfs Jelle , van den Ham Jonathan , Meulendijks Nicole , Sastre Francesc , Buskens Pascal 
Published: January 2022

AbstractDistinguishing between photothermal and non‐thermal contributions is essential in plasmon catalysis. Use of a tailored optical temperature sensor based on fiber Bragg gratings enabled us to obtain an accurate temperature map of an illuminated plasmonic catalyst bed with high spatiotemporal resolution. Its importance for quantification of the photothermal and non‐thermal contributions to plasmon catalysis is demonstrated using a Ru/Al2O3 catalyst. Upon illumination with LEDs, we measured temperature differences exceeding 50 °C in the top 0.5 mm of the catalyst bed. Furthermore, we discovered differences between the surface temperature and the temperature obtained via conventional thermocouple measurements underneath the catalyst bed exceeding 200 °C at 2.6 W cm−2 light intensity. This demonstrates that accurate multi‐point temperature measurements are a prerequisite for a correct interpretation of catalysis results of light‐powered chemical reactions obtained with plasmonic catalysts.