bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freedom: An enactive possibility
Authors: Rostowski Adam 
Published: November 2022

Abstract
In Freedom: An Impossible Reality (FAIR), Raymond Tallis finds room in a law-abiding universe for a uniquely human form of agency, capable of envisioning and pursuing genuinely open possibilities, thereby deflecting rather than merely inflecting the course of events, in accordance with self-owned intentions, reasons and goals. He argues that the genuinely free human pursuit of such propositional attitudes depends on our acting from a “virtual outside”, at an epistemic distance from the physical world that reveals not only what is the case, but that it is the case.
The enactive approach in cognitive science and philosophy of mind aims to supersede the cognitivist traditional that has long dominated the field, by reframing cognition as an agentʼs immediate, embodied engagement with its environment. In an appendix of FAIR, Tallis argues that this approach risks both eliminating propositional attitudes, and collapsing the epistemic distance between agent and world. He concludes that if enactive theorists are to distinguish between genuinely pursuing an intention and merely responding to a stimulus, their corrective to cognitivism is in need of a correction of its own.
This paper argues that such a correction is already to be found within the enactive literature, and furthermore, that it bears striking similarities to Tallis own account of what makes human agency unique. It is therefore concluded that the case for freedom set out in FAIR is compatible with the enactive approach.
On the importance of a human-scale breadth of view: Reading Tallis’ freedom
Authors: Halák Jan 
Published: November 2022

Abstract
This paper is my commentary on Raymond Tallis’ book Freedom: An Impossible Reality (2021). Tallis argues that the laws described by science are dependent on human agency which extracts them from nature. Consequently, human agency cannot be explained as an effect of natural laws. I agree with Tallis’ main argument and I appreciate that he helps us understand the systematic importance of a human-scale breadth of view regarding any theoretical investigation. In the main part of the paper, I critically comment on Tallis’ interpretation of several more loosely associated topics from a phenomenological perspective. Firstly, I reconsider Tallis’ account of intentionality as a factor that opens a distance between the cognizer and the world. Whereas Tallis emphasizes that agency requisitions aspects of the world to achieve its goals, I point out that agency does not determine the meaning of things unidirectionally and independently of all context. A self-controlled agency is provisionally reached through a process of ‘deindexicalization’ of our passive intentional capacities, that is, by creating and maintaining new, different worldly contexts. Subsequently, I analyze Tallis’ description of our intentional relation to spatiotemporally distant possibilities. In my view, Tallis underestimates the extent to which our intentional relation to possibilities is pre-reflexive and pre-predicative and hence independent of propositional attitudes. Finally, I consider Tallis’ interpretation of nature and show that it is deeply influenced by the sciences of nature. In contrast, I argue that agency can be properly described only if we understand it as an intervention in a lifeworld already imbued with sense, not merely a physical or material nature.
The seemingly ordinary complexity of daily life
Authors: Kavenna Joanna 
Published: November 2022

Abstract
The author is in essential agreement with Tallis, that when we only deploy one mode of interpretation, ie the scientific mode, we lose the fundamental realities of human experience, including the experience of free will, on which, ironically, scientific practice depends. Tallis’s philosophical stance is compared to that of Owen Barfield and his work on free will is placed within the context of his other books. A sense of wonder is common to all of them.
The ontology of freedom
Authors: Tartaglia James 
Published: November 2022

Abstract
I begin by clarifying Tallis’s revisionary terminology, showing how he redraws the lines of the traditional debate about free will by classifying himself as a compatibilist, when in standard terms he is an incompatibilist. I then examine what I take to be the two main lines of argument in Freedom, which I call the Mysterian Argument and the Intentionality Argument. I argue that neither can do the required work on its own, so I ask how they are supposed to combine. I then argue that a commitment to the ontological priority of everydayness, of the kind suggested in chapters 5 and 6 of Freedom, might combine the arguments in such a way as to secure Tallis’s conclusion. I conclude that the argument of Freedom requires positive metaphysical commitment of a kind Tallis has yet to provide.
An orthotropic thermo-viscoelastic infinite medium with a cylindrical cavity of temperature dependent properties via MGT thermoelasticity
Authors: Abouelregal Ahmed E. , Ahmad Hijaz , Yavuz Mehmet , Nofal Taher A. , Alsulami M. D. 
Published: November 2022

Abstract
The current work is devoted to introduce a novel thermoelastic heat conduction model where the Moore-Gibson-Thompson (MGT) equation describes the heat equation. The constructed model is characterized by allowing limited velocities of heat wave propagation within the material, consistent with physical phenomena. The Green–Naghdi Type III model is improved by introducing the delay factor into the modified Fourier law. Also, from the presented model, some other models of thermoelasticity can be derived at specific states. Based on the suggested model, an infinite orthotropic material with a cylindrical hole exposed to time-dependent temperature variation was studied. It has also been considered that the coefficient of thermal conductivity varies with temperature, unlike in many other cases where this value is considered constant. The viscoelastic material of the investigated medium was assumed to be of the Kelvin–Voigt type. The Laplace transform method provides general solutions to the studied field variables equations. The effects of viscosity and thermal variability parameters on these fields are discussed and graphically presented. In addition, the numerical results were presented in tables, and a comparison with previous models was made to ensure the accuracy of the results of the proposed model.
Study on fine characterization and reconstruction modeling of porous media based on spatially-resolved nuclear magnetic resonance technology
Authors: Niu Zhongkun , Yang Zhengming , Luo Yutian , Zhang Yapu , Zhao Xinli , Chang Yilin , Chen Xinliang 
Published: November 2022

Abstract
At present, image analysis and digital core are the main approaches for porous media reconstruction modeling, and they are both based on the real pore skeleton physical structure of porous media. However, it is difficult to reconstruct the reservoir and seepage characteristics of the real samples because of the limitations of accuracy in characterization techniques (imaging). In order to solve this problem and break through the barriers caused by the lack of accuracy, Spin-echo serial peripheral interface sequence of low field nuclear magnetic resonance is used to test the saturated water rock core with spatially resolved T2 distributions. Based on the experimental results of 1D T2 distributions, a novel method for fine reconstruction modeling of porous media is proposed, and the porous media model reconstructed by this new method better reproduces the reservoir and seepage characteristics of the original samples. Taking some of the tested porous media cores (P58 and Y75) as examples, representative elementary volume (REV)-lattice Boltzmann method (LBM) is used to simulate the flow field. Ensuring that the error of standard case is only 0.36% when multi-relaxation time REV-LBM is used, the distribution of porosity and permeability have been calculated and compared with the experimental data. The overall permeability error of the reconstructed porous media model is only 6.15 and 7.60%, respectively. Furthermore, the porosity and permeability error of almost all measuring points can be maintained within 3 and 8%. In addition, this method improves the efficiency of the existing reconstruction modeling methods, reduces the test cost, and makes the reconstruction modeling of porous media easier to operate, which has promising development prospects.
Giving volume to the elephant in the imaging room
Authors: Agrawal Anurag , Agrawal Disha 
Published: November 2022

Rudolf Virchow, the founder of cellular pathology, held that even when physical or chemical investigations yield the laws of physiology or medicine, the anatomist can still proudly state: This is the structure in which the law becomes manifest. In his words, “physiology presupposes anatomy.” Pathological anatomy studies, at usual microstructural scales (approximately 1–100 μm), via light microscopic 2D histology, provided many insights into structure–function relationships of health and disease. For example, such studies established the progression of granulomas, bronchial erosions, microcavities, and destructive lung disease in tuberculosis. While histologic studies remain the cornerstone of such efforts, the advent of nano or micro‐X‐ray computed tomography (n/μCT) has now made it additionally possible to obtain 3D visualizations of soft and hard tissues, while preserving the tissue for additional investigations. This has applications for old as well as new diseases (Katsamenis et al, 2019; Tanabe & Hirai, 2021).
Role of the hypothalamus in ghrelin effects on reproduction: sperm function and sexual behavior in male mice
Authors: Belén Poretti María , Bianconi Santiago , Luque Eugenia , Martini Ana Carolina , Vincenti Laura , Cantarelli Veronica , Torres Pedro , Ponzio Marina , Schiöth Helgi B , Carlini Valeria Paola 
Published: November 2022

In brief
Ghrelin signals to the hypothalamus inhibit reproduction during times of food scarcity. In this study, we demonstrate that ghrelin impairs sperm quality in male mice.

Abstract
Ghrelin (GHRL) is an orexigenic peptide that has been investigated as one of the signals responsible for the reproductive performance of mammals under fluctuating metabolic conditions. Central GHRL administration impairs spermatogenesis in mice by regulating the hypothalamic–pituitary–gonadal axis function. In the present study, the hypothalamus role as a mediator of GHRL effects on sperm fertilizing capacity and male sexual behavior was evaluated. After 42 days of hypothalamic GHRL infusion or artificial cerebrospinal fluid, in vitro and in vivo sperm fertilizing capacity, testicular α-tubulin, speriolin gene expression and spermatic α-tubulin protein were evaluated. Hypothalamic expression of genes Kiss1, Gpr54 and Gnrh was also studied. The second group of animals was infused with one time only GHRL or artificial cerebrospinal fluid into the hypothalamus to evaluate the effects on sexual behavior. Results demonstrated that chronic GHRL administration to male mice significantly increased the percentages of pre-implantation embryo loss and the number of post-implantation embryo loss. In relation to the gene expression, our results show a relative decrease of Kiss1, Gpr54 and Spatc1. Although no significant differences were observed in the quantitative expression of α-tubulin protein, qualitative changes in its expression pattern were observed. In addition, a dual effect on sexual behavior was observed: 40% of the treated animals showed a significant reduction in the number of mounts and intromissions, while a 60% showed a significant decrease in ejaculation latency vs control animals. In conclusion, our results provide evidence that central GHRL administration possibly induces failure in embryo development and/or implantation in the females mated with treated males, possibly because of a negative effect in the α-tubulin pattern.
Optimization of Cellulose Nanocrystals from Ensete Ventricosum Pseudo Stem Fiber Using Response Surface Methodology
Authors: Dube Abnet Mengesha 
Published: November 2022

Abstract
In the current world, cellulose is employed in many different applications to create cutting-edge materials like cellulose nanocrystals, which have numerous favorable uses in food packaging, medicine delivery, electronics, and many other fields. In this study, fibers from the Ensete ventricosum pseudo stem were hydrolyzed with sulfuric acid to produce cellulose nanocrystals. To get rid of non-cellulosic and amorphous components, mechanical and chemical pretreatments like water soaking, dewaxing, alkali treatment, and bleaching were carried out. The yield as responses was used to optimize the operation conditions of cellulose nanocrystals extraction from Ensete ventricosum pseudo stem fiber using Response Surface Methodology. The maximum production of cellulose nanocrystals is 39.49 percent with a crystallinity index of 69.7 percent under optimal hydrolysis conditions of 49 percent sulfuric acid concentration, 52°C hydrolysis temperature, and 36 minutes of hydrolysis time. The correctness of the results and the optimization technique itself have both been validated. Consequently, CNCs from EVPSF have potential use in a variety of fields with added value.
Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates
Authors: Shimizu Kimiko , Inoue Ken-ichi , Oishi Takao , Takada Masahiko , Fukada Yoshitaka , Imai Hiroo 
Published: November 2022

Abstract
Cognitive functions depend on the time of day in various organisms. Previously, we found that 24-hour recognition memory performance of nocturnal mice changes diurnally through SCOP protein-dependent regulation. It remains unknown whether SCOP-dependent regulation of memory performance is conserved across species with diurnal/nocturnal habits. We tested whether the time of day affects the memory performance of diurnal Japanese macaques. The memory association between bitter taste of drinking water and the nozzle color of the water bottle was established during the light period of the day to evaluate of memory performance for macaques. Here we found diurnal variation of declarative memory in Japanese macaques. The middle of the daytime is the most effective time for memory performance during the light period. To assess whether SCOP is involved in declarative memory performance, we interfered with SCOP expression by using lentiviral vector expressing shRNA against Scop. Scop knockdown in the hippocampus abrogated the memory performance in the middle of the daytime. Our results implicate that SCOP in the hippocampus is necessary for the diurnal rhythm of the memory system and that the SCOP-dependent memory regulation system could be conserved in mammals.
Characteristics of Kenyan Women Enrolled in a Randomized Trial on Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention
Authors: Oware Kevin , Adiema Lydia , Rono Bernard , Violette Lauren R. , McClelland R. Scott , Donnell Deborah , Scoville Caitlin W. , Odoyo Josephine , Baeten Jared M. , Bukusi Elizabeth , Stewart Jenell 
Published: November 2022

Abstract

Introduction
The global incidence of sexually transmitted infections (STIs) has been rapidly increasing over the past decade, with more than one million curable STIs being acquired daily. Young women in sub-Saharan Africa have a high prevalence and incidence of both curable STIs and HIV. The use of doxycycline as a prophylaxis to prevent STI infections is promising; however, clinical trials, to date, have only been conducted among men who have sex with men (MSM) in high-income settings. We describe the characteristics of participants enrolled in the first trial to determine the efficacy of doxycycline post-exposure prophylaxis (PEP) to reduce STI incidence among women.
Methods
This is an open-label 1:1 randomized clinical trial of doxycycline PEP efficacy to reduce incident bacterial STIs – Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum – among Kenyan women aged ≥18 and ≤30 years. All were also taking HIV pre-exposure prophylaxis (PrEP). We describe the baseline characteristics of participants.
Results
Between February 2020 and November 2021, 449 women were enrolled. The median age was 24 years (IQR 21–27), the majority were never married (66.1%), 370 women (82.4%) reported having a primary sex partner, and 33% had sex with new partners in the 3 months prior to enrolment. Two-thirds (67.5%, 268 women) did not use condoms, 36.7% reported transactional sex, and 43.2% suspected their male partners of having sex with other women. Slightly less than half (45.9%, 206 women) were recently concerned about being exposed to an STI. The prevalence of STIs was 17.9%, with C. trachomatis accounting for the majority of infections.
Conclusion
Young cisgender women using HIV PrEP in Kenya and enrolled in a trial of doxycycline postexposure prophylaxis had a high prevalence of curable STIs and represent a target population for an STI prevention intervention.
A multi factor combination optimization design of a two degree of freedom mechanical system
Authors: Wang Yang , Xu Cheng , He Long 
Published: November 2022

Abstract
Floating machine gun is a typical two degree of freedom mechanical system, and its multi factor combination optimization design is an urgent problem in engineering. In this paper, a two degree of freedom dynamic simulation model of a new floating machine gun with bidirection buffer floating springs is established, and the correctness of the model is verified by comparison with the experimental results. "Maximum recoil displacement of floating body" and “firing speed” is proposed to characterize performance of floating machine gun. The multi factor combination design of floating machine gun is carried out through orthogonal optimization design. The influence of multi factors on the maximum recoil displacement of floating body and firing speed is studied, and the optimal combination solution is obtained. The results show that the pressure of the piston chamber, the energy storage of the floating spring and the mass of the floating body have a great influence on the maximum recoil displacement of the floating body, and the energy storage of the recoil spring and the mass of the bolt carrier group have a great influence on the firing speed. After selecting the best combination according to the variance results, the maximum recoil displacement of the floating body is reduced by about 20.2%, and the firing speed is increased by about 26.6%, which effectively improves the floating performance of the floating machine gun. Keywords: Two degree of freedom system; Floating technology; Machine gun system; Multi factor combination optimization design
Identification and Validation of m6A-GPI Signatures as a Novel prognostic Model for Colorectal Cancer
Authors: Ma Bin , Bao Simeng , Li Yongmin 
Published: November 2022

Abstract
In order to develop an N6-methyladenosine-related gene prognostic index (m6A-GPI) that can predict the prognosis in colorectal cancer (CRC), we obtained m6A-related differentially expressed genes (DEGs) based on The Cancer Genome Atlas (TCGA) and m6Avar database, seven genes were screened by weighted gene co-expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) analysis. Then, m6A-GPI was constructed based on the risk score. Survival analysis indicated that patients in the lower m6A-GPI group have more prolonged disease-free survival (DFS), and different clinical characteristic groups (tumor site and stage) also showed differential risk scores. In the analysis of the molecular characteristics, the risk score is positively associated with homologous recombination defects (HRD), copy number alterations (CNA), and the mRNA expression-based stemness index (mRNAsi). In addition, m6A-GPI also plays an essential role in tumor immune cell infiltration. The immune cell infiltration in the low m6A-GPI group is significantly higher in CRC. Moreover, we found that CIITA, one of the genes in m6A-GPI was up-regulated in CRC tissues based on real-time RT-PCR and Western blot. m6A-GPI is a promising prognostic biomarker that can be used to distinguish the prognosis of CRC patients in CRC.
The influence of cathodic θ-Al2Cu intermetallic geometry on the localized-corrosion-triggered conversion coating deposition
Authors: Sainis Salil , Zanella Caterina 
Published: November 2022

Abstract
Micro-galvanic activity between the cathodic intermetallics and the anodic matrix in an aluminium alloy drives the localized deposition of cerium conversion coatings. It is at the cathodic sites that conversion coating deposition is initiated due to the local pH gradient created because of cathodic reduction reaction over them. The intermetallics’ chemical, electrochemical and geometrical properties critically influence the deposition, but very little is empirically known about the latter. With the objective of understanding the effect of intermetallic geometry, this work looks closely into the deposition on nearly 550 eutectic θ-Al2Cu type intermetallics with different size regimes to decipher the controlling geometrical variables. While this work investigates influence of intermetallic geometry on localized deposition, parallel conclusions may also be drawn about the corrosion activity around intermetallics as a function of their geometry due to these coatings being triggered by localized corrosion.
Nurses lived Experiences, burdens and coping strategies during the COVID-19 pandemic
Authors: Jarrad Reem , ALdasoqi Khadeejeh , ALnatsheh Malak 
Published: November 2022

Abstract

This is a qualitative interpretative phenomenological study which was designed to navigate through nurses’ lived experiences, burdens and both positive and negative coping strategies while working with COVID-19 patients. The sample included 20 nurses who had worked with COVID-19 patients for more than or equal to six months in the country’s variable health sectors. The interviews were conducted between 1,October,2021 and 15,April,2022. At that time, the third COVID wave had elapsed and we were peaking on a fourth pandemic wave, so included participants had lived through a minimum of two to three peaks. Six themes had emerged which were: nurses coping with COVID-19 crisis, professional relationship burden, personal burden, environmental burden, physical symptom burden and emotional burden of the crisis. Nurses lived experiences during the pandemic were deep and intense and moderately to highly affecting their ways of thinking, feeling and behaving. Certainly such experience had opened nurses eyes on countless number of challenges that could be faced during the times of adversity which requires special attention, care and preparation on many levels. The minimal preparatory levels are personal, departmental, organizational and strategic at the level of country’s proactive health planning.