bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of the model for predicting prognosis by key genes regulating EGFR-TKI resistance
Authors: Zhuge Jinke , Wang Xiuqing , Li Jingtai , Wang Tongyuan , Wang Hongkang , Yang Mingxing , Dong Wen , Gao Yong 
Published: November 2022

Background: Previous studies have suggested that patients with lung adenocarcinoma (LUAD) will significantly benefit from epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). However, many LUAD patients will develop resistance to EGFR-TKI. Thus, our study aims to develop models to predict EGFR-TKI resistance and the LUAD prognosis.Methods: Two Gene Expression Omnibus (GEO) datasets (GSE31625 and GSE34228) were used as the discovery datasets to find the common differentially expressed genes (DEGs) in EGFR-TKI resistant LUAD profiles. The association of these common DEGs with LUAD prognosis was investigated in The Cancer Genome Atlas (TCGA) database. Moreover, we constructed the risk score for prognosis prediction of LUAD by LASSO analysis. The performance of the risk score for predicting LUAD prognosis was calculated using an independent dataset (GSE37745). A random forest model by risk score genes was trained in the training dataset, and the diagnostic ability for distinguishing sensitive and EGFR-TKI resistant samples was validated in the internal testing dataset and external testing datasets (GSE122005, GSE80344, and GSE123066).Results: From the discovery datasets, 267 common upregulated genes and 374 common downregulated genes were identified. Among these common DEGs, there were 59 genes negatively associated with prognosis, while 21 genes exhibited positive correlations with prognosis. Eight genes (ABCC2, ARL2BP, DKK1, FUT1, LRFN4, PYGL, SMNDC1, and SNAI2) were selected to construct the risk score signature. In both the discovery and independent validation datasets, LUAD patients with the higher risk score had a poorer prognosis. The nomogram based on risk score showed good performance in prognosis prediction with a C-index of 0.77. The expression levels of ABCC2, ARL2BP, DKK1, LRFN4, PYGL, SMNDC1, and SNAI2 were positively related to the resistance of EGFR-TKI. However, the expression level of FUT1 was favorably correlated with EGFR-TKI responsiveness. The RF model worked wonderfully for distinguishing sensitive and resistant EGFR-TKI samples in the internal and external testing datasets, with predictive area under the curves (AUC) of 0.973 and 0.817, respectively.Conclusion: Our investigation revealed eight genes associated with EGFR-TKI resistance and provided models for EGFR-TKI resistance and prognosis prediction in LUAD patients.
Serial analyses of clinical spectra and outcomes in Chinese women with pregnancy-induced optic neuritis
Authors: Bai Wenhao , Sun Mingming , Song Honglu , Li Hongen , Xu Xintong , Chen Xiyun , Zhao Yixuan , Chen Biyue , Yao Sheng , Xu Quangang , Wei Shihui , Zhou Huanfen , Yu Shengyuan 
Published: November 2022

ObjectiveThis study aimed to investigate the clinical spectra and outcomes in pregnancy-related optic neuritis (ON).MethodsWe analyzed the clinical subtype and prognosis of women with pregnancy-related ON in the neuro-ophthalmology department of the First Medical Center at the Chinese PLA General Hospital from January 2014 to December 2019.ResultsA total of 54 patients, including 21 (38.9%) with idiopathic ON (ION), 27 (50.0%) with aquaporin-4 (AQP4)-ON, and 6 (11.6%) with myelin oligodendrocyte glycoprotein (MOG)-ON, who experienced 58 informative pregnancies and 67 episodes of pregnancy-related ON were assessed. Among the ON attacks, there were 11 (16.4%) during pregnancy and 56 (83.6%) within 1 year postpartum (PP1) or after abortion, including 33 (49.3%) in the first trimester. In total, 14 (25.9%) patients with ON onset before pregnancy had a higher relapse rate during PP1 than within 1 year before pregnancy (p = 0.021), and 24 (85.7%) eyes with ION and nine (100%) with MOG-ON had significantly better visual outcomes (p ≥ 0.5) than those with AQP4-ON (14, 35%) (p &lt; 0.001 and p &lt; 0.001, respectively). Two AQP4-ON patients had premature birth and low baby weight, respectively. There were no birth defects or stillbirths.ConclusionThe significantly increased relapse rate and numerous cases of ON after pregnancy suggest that delivery adversely affects the course of ON.
The association between the severity and distribution of white matter lesions and hemorrhagic transformation after ischemic stroke: A systematic review and meta-analysis
Authors: Wang Youjie , Bai Xueling , Ye Chen , Yu Yifan , Wu Bo 
Published: November 2022

Background and purposeAs a part of the natural course of ischemic stroke, hemorrhagic transformation (HT) is a serious complication after reperfusion treatment, which may affect the prognosis of patients with ischemic stroke. White matter lesions (WMLs) refer to focal lesions on neuroimaging and have been suggested to indicate a high risk of HT. This systematic review and meta-analysis aimed to summarize current evidence on the relation between WML and HT.MethodsThis systematic review was prepared with reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched PubMed, Embase, Web of Science, and Cochrane Library databases for publications on WML and HT in patients with ischemic stroke. Odds ratios (ORs) and 95% confidence intervals (CIs) from eligible studies were combined to quantify the association between the severity of WML and the risk of HT. In addition, the descriptive analysis was adopted to evaluate the influence of different WML distributions on predicting HT.ResultsA total of 2,303 articles were identified after removing duplicates through database searching, and 41 studies were included in our final analysis. The meta-analysis showed that the presence of WML was associated with HT (OR = 1.62, 95%CI 1.08–2.43, p = 0.019) and symptomatic intracerebral hemorrhage (sICH) (OR = 1.64, 95%CI 1.17–2.30, p = 0.004), and moderate-to-severe WML indicated a high risk of HT (OR = 2.03, 95%CI 1.33–3.12, p = 0.001) and sICH (OR = 1.92, 95%CI 1.31–2.81, p &lt; 0.001). The dose–response meta-analysis revealed risk effects of increasing the severity of WML on both HT and ICH. In addition, both periventricular WML (PWML) (five of seven articles) and deep WML (DWML) (five of six articles) were shown to be associated with HT.ConclusionsWhite matter lesions are associated with overall HT and sICH in patients with ischemic stroke, and more severe WMLs indicate a high risk of HT and sICH. In addition, both PWML and DWMLs could be risk factors for HT.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: PROSPERO CRD42022313467.
A time-frequency denoising method for single-channel event-related EEG
Authors: Yan Wenqiang , Wu Yongcheng 
Published: November 2022

IntroductionElectroencephalogram (EEG) acquisition is easily affected by various noises, including those from electrocardiogram (ECG), electrooculogram (EOG), and electromyogram (EMG). Because noise interference can significantly limit the study and analysis of brain signals, there is a significant need for the development of improved methods to remove this interference for more accurate measurement of EEG signals.MethodsBased on the non-linear and non-stationary characteristics of brain signals, a strategy was developed to denoise brain signals using a time-frequency denoising algorithm framework of short-time Fourier transform (STFT), bidimensional empirical mode decomposition (BEMD), and non-local means (NLM). Time-frequency analysis can reveal the signal frequency component and its evolution process, allowing the elimination of noise according to the signal and noise distribution. BEMD can be used to decompose the time-frequency signals into sub-time-frequency signals for noise removal at different scales. NLM relies on structural self-similarity to locally smooth an image to remove noise and restore its main geometric structure, making this method appropriate for time-frequency signal denoising.ResultsThe experimental results show that the proposed method can effectively suppress the high-frequency components of brain signals, resulting in a smoother brain signal waveform after denoising. The correlation coefficient of the reference signal, a superposition average of multiple trial signals, and the original single trial signal was determined, and then correlation coefficients were calculated between the reference signal and single trial signals processed by time-frequency denoising, ensemble empirical mode decomposition (EEMD)-independent component analysis (ICA), EEMD-canonical correlation analysis (CCA), and wavelet threshold denoising methods. The correlation coefficient was highest for the signal processed by the time-frequency denoising method and the reference signal, indicating that the single trial signal after time-frequency denoising was most similar to the waveform of the reference signal and suggesting this is a feasible strategy to effectively reduce noise and more accurately determine signals.DiscussionThe proposed time-frequency denoising method exhibits excellent performance with promising potential for practical application.
Case report: A rare case of neutropenia caused by pembrolizumab in squamous lung cancer and literature review
Authors: Tan Qiaoyun , Liu Lichao , Huang Yu , Dong Xiaorong , Chen Lingjuan 
Published: November 2022

BackgroundImmune checkpoint inhibitors, including anti-PD-1 therapies, have prolonged overall survival in patients with a variety of cancers, and immunotherapy is sometimes associated with immune-related adverse events (irAEs); however, hematological toxicity, especially neutropenia, is rare.Case presentationA 78-year-old man with squamous lung cancer, with brain metastasis, was treated with pembrolizumab and albumin-bound paclitaxel as first-line treatment for one cycle and changed to pembrolizumab plus anlotinib at the second cycle. After two therapy cycles, grade 4 neutropenia developed, which mainly contributed to irAEs. The patient was started on granulocyte colony-stimulating factor (G-CSF) but did not improve; he was then treated with corticosteroids, and neutrophil counts gradually returned to normal levels. However, the patient eventually died because of neurological problems.ConclusionGrade 4 neutropenia associated with ICI, although rare, is often severe and presents with infectious complications; it needs to be diagnosed early, and clinicians should ensure prompt and proper management to such patients.
Does air quality improvement promote enterprise productivity increase? Based on the spatial spillover effect of 242 cities in China
Authors: Le Dong , Li Yusong , Ren Fei 
Published: November 2022

IntroductionAir pollution not only harms people's health, but also impedes urban economic development. This study aims to analyze how air quality improvement affects enterprise productivity. And then from regional and time heterogeneities' aspects to investigate if the air quality improvement increase enterprise productivity.MethodsThe data were obtained from China Industrial Enterprise Database and China Patent Database,and this study used Spatial Durbin Model to analyze how air quality improvement affects enterprise productivity.ResultsThe results show that: (1) air quality improvement and its spatial spillover effect can significantly increase enterprise productivity in adjacent areas. (2) After 2010, the government implemented more stringent measures to prevent and control air pollution, which made the air quality improvement promote enterprise productivity increase more obviously. The air quality improvement in eastern and central regions was less obvious than in western regions. (3) Air quality improvement can increase enterprise productivity by improving enterprise innovation quality, ensuring the health of urban residents, and increasing the stock of urban human capital.ConclusionAir quality improvement and its spatial spillover effect can significantly increase enterprise productivity in adjacent areas. So this study puts forward some policy enlightenment, such as establishing an air pollution detection system, using an intelligent network supervision platform, and implementing a coordinated defense and governance system.
Internet use and health status among older adults: The mediating role of social participation
Authors: Hou Bin , Li Yumei , Wang Haixia 
Published: November 2022

BackgroundThe acceleration of population aging and the arrival of the informatization make more and more older adults use the Internet, and its use is having an impact on their health. However, the relationship between internet use and the health of older adults and the mechanism of the effect of internet use on the health are not very clear.MethodsMultiple linear regression models to explore the correlation between internet use and health status in the 3,141 individuals aged ≥60 years were used. Propensity score matching (PSM) method was used to test the robustness of the regression results. In addition, sequential recursive models was used to examine the mediating effect of social participation on the relationship between internet use and health status.Results and discussionWe found a significant positive relationship between internet use and health status, and social participation mediated the relationship between internet use and health status. In addition, the effect of internet use on health status was different among older adults in rural and urban areas.ConclusionsThe development and application of internet products adapted to the development of an aging society should be accelerated to meet their needs for continued socialization. The forms and activities of social participation for the elderly groups should be enriched and public service internet usage training seminars should be conducted to improve internet skills.
Effects of COVID-19-related psychological distress and anxiety on quality of sleep and life in healthcare workers in Iran and three European countries
Authors: Zangeneh Soroush Morteza , Tahvilian Parisa , Koohestani Sepideh , Maghooli Keivan , Jafarnia Dabanloo Nader , Sarhangi Kadijani Mojtaba , Jahantigh Sepehr , Zangeneh Soroush Masoud , Saliani Amitis 
Published: November 2022

Introduction:The COVID-19 pandemic has considerably affected human beings most of whom are healthcare workers (HCWs) combating the disease in the front line.MethodsThis cross-sectional study aims to explore the effects of stress and anxiety caused by COVID-19 on the quality of sleep and life in HCWs, including physicians, nurses, and other healthcare staff. In this global study, we asked 1,210 HCWs (620 and 590 volunteers from Iran and European countries, including Germany, the Netherlands, and Italy, respectively), who age 21–70, to participate in the test. Several measures of COVID-related stress, anxiety, sleep, and life quality, including the 12-item General Health Questionnaire (GHQ-12), Fear of COVID-19 scale (FCV-19S), Beck Anxiety Inventory (BAI), the Pittsburgh Sleep Quality Index (PSQI), and World Health Organization Quality of Life-BREF (WHOQOL-BREF) are recorded.ResultsVolunteers reported high rates of stress and anxiety and poor sleep quality as well as lower quality of life. The correlation analysis between the measures is reported. According to the results, regardless of the location, HCWs, predominantly female nurses, developed anxiety and stress symptoms which consequently resulted in lower sleep and life quality. Both for Iranian and the European HCWs, significant differences existed between nurses and the other two groups, with the p-values equal to 0.0357 and 0.0429 for GHQ-12, 0.0368, and 0.714 for BAI measure. Even though nurses reported the most stress, anxiety, fear of COVID-19, lower quality of life and sleep in both countries, and also an increase in other measures as well, there existed no statistically significant difference in FCV-19S, PSQI, and WHOQOL-BREF.DiscussionThis study helps to expand our knowledge the effects of pandemics on HCWs and also for healthcare management to predict HCW's mental health conditions in similar situations.
Automedicação: uma revisão de literatura acerca dos fatores relacionados a esse fenômeno
Authors: Da Silva Dannycleia Mota , Rodrigues Francimeira Leitão , Ramalho Raiane Gama de Souza , Dos Santos Thafaela Rodrigues 
Published: November 2022

Introdução: A automedicação pode ser compreendida como a prática constante de ingerir substâncias de ação terapêutica sem o acompanhamento/aconselhamento de um profissional de saúde qualificado. Este fenômeno é de caráter global e infere em uma problemática bastante pertinente na sociedade, pois traz riscos à saúde da população. Este trabalho tem como objetivo relatar as principais causas da automedicação, e incidência e prevalência desse ato a sociedade brasileira. Metodologia: o presente estudo trata-se de uma revisão integrativa de literatura a estratégia de identificação e seleção dos estudos ocorreu por meio de busca de publicações disponíveis nas bases de dados eletrônica Scientific Electronic Library Online (SciELO), PubMed, e Biblioteca Virtual em Saúde (BVS). O processo foi feito utilizando os seguintes Descritores em Ciências da Saúde (DeCS): automedicação, saúde e riscos e o operador booleando AND para efetuar a combinação dos descritores. Resultados: A amostra totalizou 7 materiais, incluindo artigos. Para a apresentação dos resultados, os materiais avaliados levaram em consideração, o ano de publicação, tipo de estudo de cada pesquisa, bem como aqueles que apresentassem o tema de interesse. Considerações finais: Com o levantamento de trabalhos selecionados foi percetível que a automedicação pode ser considerada um problema de saúde publica, pois pode inferir em uma diversidade de impasses a saúde do individuos. Com base nisso, é evidente que foi possivel alcaçar o objetivo proposto pela pesquisa uma vez foi encontrado pesquisas sufiticiente que mostrasse as principais causas da automedicação, e incidência e prevalência desse ato a sociedade brasileira.
IMPLEMENTASI LOGIKA FUZZY DALAM MENGOPTIMALKAN JUMLAH PRODUKSI GARAM BERYODIUM (STUDI KASUS: KELOMPOK USAHA GARAM BERYODIUM NATAGA SABU RAIJUA)
Authors: Biha Yolanda Prapatmi , Pangaribuan Rapmaida M , Ginting Keristina Br 
Published: November 2022

Kelompok Usaha Nataga Sabu Raijua merupakan salah satu tempat produksi garam beryodium di Kabupaten Sabu Raijua yang menggunakan teknik Geomembran. Salah satu permasalahan yang dialami oleh tempat produksi garam beryodium ini adalah tingkat jumlah produksi garam beryodium yang tidak pasti. Metode Tsukamoto merupakan salah satu metode dalam logika fuzzy yang mampu menganalisis sistem yang tidak pasti ini dengan menghasilkan jumlah produksi yang optimal. Dalam mengoptimalkan jumlah produksi menggunakan metode Tsukamoto diperlukan variabel input dan variabel output. Variabel input yang digunakan adalah jumlah bahan baku, jumlah persediaan garam beryodium non kemasan, jumlah persediaan garam beryodium dalam kemasan dan jumlah permintaan sedangkan variabel output yang digunakan adalah jumlah produksi garam beryodium. Berdasarkan analisa dengan menggunakan Metode Tsukamoto diperoleh jumlah rata-rata produksi garam beryodium Nataga Sabu Raijua Sebesar 2935,5 Kg dengan nilai error sebesar 16,84% sehingga Metode ini dapat digunakan dalam menentukan jumlah produksi garam beryodium.
A compreensão dos conceitos de fenômeno religioso em Eliade e Durkheim
Authors: Almeida Leandro de 
Published: November 2022

O presente artigo objetivou apresentar a descrição do fenômeno religioso, nas perspectivas da filosofia da religião, em conjunto com a descrição realizada pela sociologia. Buscou-se nesse aspecto, reportar-se ao construto teórico de Mircea Eliade e Émile Durkheim, apresentando um panorama introdutório dos conceitos, servindo de base para aprofundamentos futuros dos estudos de religião, a partir de uma visão centrada na dimensão de pertinência da religião e dos fenômenos religiosos, como subjacente à dimensão humana.
ВІЙСЬКОВО-ПАТРІОТИЧНЕ ВИХОВАННЯ УЧНІВСЬКОЇ МОЛОДІ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Ціпан Тетяна 
Published: November 2022

У статті розкрито проблему організації військово-патріотичного виховання учнівської молоді в умовах воєнного часу.
На основі аналізу нормативно-правових документів визначено мету й завдання формування громадянина-патріота в умовах воєнного часу. Вирізнено чинники, які впливають на формування в учнівської молоді готовності до захисту України: індивідуально-психологічні, психолого-педагогічні, соціально-педагогічні.
З’ясовано, що військово-патріотичне виховання, як один з напрямів національно-патріотичного виховання, ґрунтується на духовно-моральних цінностях українського народу, передбачає прикладну фізичну підготовку, підготовку з навчального предмету «Захист України», безпеки життєдіяльності, а також організацію позакласної виховної роботи, що в цілому забезпечує формування громадянськості й патріотизму в учнівської молоді, готовності до захисту України, розвиток позитивного ставлення до військової служби в різних видах військ.
Схарактеризовано форми військово-патріотичного виховання учнівської молоді в позакласній виховній роботі закладу загальної середньої освіти, чільне місце серед яких займають практико-орієнтовані. Розкрито виховний потенціал дитячо-юнацьких військово-спортивних, військово-патріотичних ігор, серед яких: «Захисник України», «Патріот», «Сокіл» («Джура»).
Моделювання теплового комфорту міського автобуса PMV-методом за допомогою CBE Thermal Comfort Tool
Authors: ВОЙЧИШИН Юрій , ЯКОВЕНКО Євгенія , ГОРБАЙ Орест , ГОЛЕНКО Костянтин , БУР’ЯН Михайло 
Published: November 2022

Системи забезпечення мікроклімату (опалення, повітрообміну та кондиціонування) формують комфортні умови перевезення. Вони є важливими з точки зору охорони здоров’я і умов праці, і тому є обов’язковим компонентом будь-якого сучасного транспортного засобу. Основні дослідження по цій тематиці проводились для автобусів, електробусів та трамваїв і приміських електричок у напрямку удосконалення роботи систем опалення, повітрообміну та кондиціонування. Метою даного дослідження є визначення сприйняття водієм теплового комфорту в салоні автобуса при компоновці, коли водій відділений перегородкою від всього салону. Було розраховано теоретичне значення метаболічної теплової енергії по кількості спожитого кисню з врахуванням метаболічних процесів в організмі людини. Згідно стандартів ASHRAE за допомогою онлайн програми CBE Thermal Comfort Tool було проведено розрахунки по PMV-методу, враховуючи основні параметри мікроклімату. Побудовано ряд діаграм, зокрема: психрометричні діаграми, діаграми залежності вологості та теплових втрат від температури. У психрометричній діаграмі для кожної точки температура за сухим термометром зона комфорту являє собою комбінацію умов з тими самими DBT і MRT, для яких PMV становить від -0,5 до +0,5. Аналіз нормативно-правової бази України з обраної тематики схиляє до висновку, що в Україні як такої її нема, а документи, які використовуються, виготовлені за кордоном або застарілі. Результати цієї роботи зможуть використовуватися для досліджень режимів роботи водія міських, приміських і автобусів дальнього прямування. На основі подальших практичних досліджень, запланованих провести на основі вищезазначеної теоретичної роботи, можна буде створити методологічні основи формування теплових режимів у кабіні водія та салоні конкретної моделі автобуса та визначити проблемні «точки» систем опалення і вентиляції великогабаритних транспортних засобів.
Ключові слова: мікроклімат, тепловий комфорт, метод PMV, сприйняття тепла, теплові виділення, теплопередача.