bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of skin wound healing in rats with experimental chronic kidney disease
Authors: Pavlov S. B. , Litvinova O. B. , Babenko N. M. 
Published: January 2022

Chronic kidney disease negatively affects the morphofunctional state of all organs due to hemodynamic and metabolic disorders. Changes in the content of cytokines observed in kidney diseases, which regulate the processes of inflammation and tissue repair, can complicate the course of the wound process. This research aimed to study disorders in the process of skin wound repair due to changes in the dynamics of production of interleukins IL-1β, IL-6, IL-10, IL-4, growth factors bFGF and VEGF in animals with experimental chronic kidney disease. The levels of interleukins and growth factors were determined on the 7th, 14th and 28th days after surgical modeling of wounds in the blood of rats with experimental chronic kidney disease and animals of the control group. To assess the dynamics and quality of wound healing, a semi-quantitative histological analysis was performed. The study showed an increase in the content of pro-inflammatory interleukins in the group of sick rats: on the 7th day the level of IL-1β was 1.19 times higher, and IL-6 – 1.55 times, on the 14th day the level of IL-1β was 1.37 times in comparison with the control group. The maximum increase in the concentration of anti-inflammatory interleukins was noted on the 28th day: IL-4 was 2.10 times higher, IL-10 – 1.39 times higher than in the control group. The content of bFGF and VEGF in animals of the control group reached its maximum on the 7th day, and in animals with chronic kidney disease – on the 15th day after surgery. Semi-quantitative histological analysis showed a decrease in indicators in the group of sick animals: the number of fibroblasts and collagen deposition – on the 7th day, reepithelialization – on the 28th day. A persistent increase in the number of polymorphonuclear leukocytes was also noted at all periods of the experiment: by 1.38, 1.99, and 9.82 times – on the 7th, 14th, and 28th days, respectively. The study showed that the dynamics of the production of interleukins and growth factors were impaired in rats with chronic kidney disease. In the process of damage regeneration in sick animals, pro-inflammatory mechanisms prevailed with the involvement of a large number of immunocompetent cells, as a result, skin wounds took longer to heal.
GC-MS analysis of cuticular waxes and evaluation of antioxidant and antimicrobial activity of Chaenomeles cathayensis and Ch. × californica fruits
Authors: Lykholat Y. V. , Khromykh N. O. , Didur O. O. , Sklyar T. V. , Holubieva T. A. , Lykholat T. Y. , Lavrentievа K. V. , Liashenko O. V. 
Published: January 2022

Fruit extracts of the Chaenomeles species are a rich source of compounds having health-promoting properties, while their distribution between the species and cultivars varies significantly depending on both genotype and environmental threats. This study aimed at discovering antioxidant and antimicrobial potential of the secondary metabolites of fruit and waxes of fruit cuticular of introduced Ch. cathayensis and Ch. × californica plants. The sum of detected polyphenols in the isopropanolic fruit extracts varied slightly between the species, while significant excesses in indices were seen for both species peel extracts as compared to pulp extracts. Antimicrobial assays carried out by disc diffusion method showed notable activity of the fruit peel and pulp extracts of both species against all tested Gram-negative and Gram-positive bacterial strains, and two Candida strains as well. Pseudomonas aeruginosa strain was the most resistant to the action of both fruit extracts, especially peel extracts of Ch. cathayensis fruits. As identified by gas chromatography-mass spectrometry (GC-MS) assays, chloroformic extracts from the fruits of cuticular waxes of Ch. cathayensis and Ch. × californica contained six prevailing fractions: aldehydes, alkanes, alcohols, esters, fatty acids and various terpenoids. The predominant compounds were tetrapentacontane (21.8% of total amount) and heptacosanal (23.1% of total), respectively in the cuticular waxes of Ch. cathayensis and Ch. × californica. Cinnamaldehyde, cis-9-hexadecenal, hexadecanoic acid, oleic acid, olean-12-ene-3,28-diol (3. beta), lupeol, diisooctyl phthalate, 9-octadecenoic acid, 1,2,3-propanetriyl ester, 1,3,12-nonadecatriene-5,14-diol and some other identified compounds are well-known for their bioactivity, indicating the feasibility of studying the antimicrobial potential of plant fruits.
Analysis of the odds ratio of developmental delay in children with biliary atresia 12 months after liver transplantation
Authors: Syrkina A. V. , Tsirulnikova O. M. , Pashkova I. E. , Silina O. V. , Chekletsova E. V. , Oleshkevich S. Yu. 
Published: January 2022

Background. Liver cirrhosis occurring before 1 year of age can affect a child’s development. Liver transplantation is the only radical treatment for decompensated cirrhosis. In biliary atresia, cirrhosis develops during the first months of life. The duration of cirrhosis in biliary atresia may vary from palliative Kasai portoenterostomy (PE) to liver transplantation. Developmental abnormalities in children with biliary atresia have been shown to occur both before and after liver transplantation. Association between duration of liver cirrhosis and psychomotor development of children has been underestimated.Objective: to determine the chances of developmental delay in children depending on the cirrhosis persistence duration.Materials and methods. The study enrolled 83 children with biliary atresia (47 children underwent palliative Kasai PE, 36 children with liver transplantation did not undergo Kasai PE). All children had their psychomotor development assessed before PE and 12 months after PE using the Griffiths psychomotor developmental scale (translation and adaptation by E.S. Keshishian) for children up to 24 months of age. Statistical analysis was performed by calculating odds ratios with 95% confidence intervals.Results. Comparative analysis showed that in the subgroup of children who underwent Kasai PE, cirrhosis persistence before transplantation was 2.6 months longer than in children without Kasai PE (p = 0.011). The odds of developmental delay in preparation for liver transplantation were 3.3 times higher in the subgroup of children who underwent Kasai palliative PE compared to children without palliative (95%, CI 1.35–8.31). The odds of developmental delay 12 months after liver transplantation were 4.4 times higher in the subgroup of children who underwent palliative Kasai PE than in children without the palliative care (95% CI 1.54–12.5).Conclusion. Children who underwent liver transplantation after palliative surgical treatment had lower levels of psychomotor development than children without palliative Kasai PE both before and 12 months after liver transplantation (p = 0.0018, p = 0.01 respectively).
The role of apoptotic bone marrow cells in activation of liver regeneration
Authors: Onishchenko N. A. , Nikolskaya A. O. , Gonikova Z. Z. , Kirsanova L. A. , Shagidulin M. Yu. , Sevastianov V. I. 
Published: January 2022

Objective: using an adoptive transfer model to study the cellular mechanisms involved in the formation of the initial stage of liver regeneration during intraperitoneal injection of a healthy recipient with apoptotic bone marrowderived mononuclear cells (BM-MNCs) from a donor after extended liver resection.Materials and methods. Male Wistar rats (n = 40) were used to create a model of adoptive transfer of apoptotic BM-MNCs (a-BM-MNCs) taken from the donor after extended liver resection to a healthy recipient. During the experiments, the animals were divided into five groups. Four experimental groups with intraperitoneal injection of the same doses to the recipient: freshly isolated BM-MNCs (group 1); BM-MNCs subjected to apoptosis for 48 hours by storage at t = 4–6 °C in phosphate-buffered saline (PBS) (group 2) or in a Custodiol HTK solution (group 3). In group 4, the animals were injected with PBS after storing BM-MNCs in it. The control animals were animals injected with saline (group 5). For selection of effective modes of apoptosis induction, BM-MNCs stained with 7AAD after incubation in solutions were analyzed by flow cytometry. Targeted transfer of regenerative signals to the recipient was assessed by the mitotic activity of hepatocytes in the liver and tubular epithelium in the kidneys, as well as by the intensity of microstructural changes in the liver 24, 48 and 72 hours after injection of the studied material.Results. BMC incubation in PBS and HTK for 48 hours at t = 4–6 °C provides the most effective accumulation of a-BM-MNCs in early apoptosis. It was shown that a-BM-MNCs retain the ability to target-focused transmission of regulatory signals to the liver supported by autophagy process during adoptive transfer. It was established that a-BM-MNCs (groups 2 and 3) in comparison to native BM-MNCs (group 1) at adoptive transfer increased the regenerative potential of the liver due to pronounced increase in the activity of autophagy processes and directed infiltration of immunomodulatory mononuclear cells in the liver.Conclusion. a-BM-MNCs create a stronger basis for development and implementation of a targeted and effective regeneration program by enhancing autophagy processes and immunomodulatory effect on mononuclear cells, which are regenerative signal carriers.
Computer modeling of different shaped patches in classical carotid endarterectomy
Authors: Loginova V. G. , Zakharov Yu. N. , Kazantsev A. N. , Shokin Yu. I. , Evtushenko E. V. , Barbarash L. S. , Onishchenko P. S. , Klyshnikov K. Yu. , Ovcharenko E. A. 
Published: January 2022

Objective: to construct geometric models of carotid bifurcation and build a computer modeling for carotid endarterectomy (CEA) operations with patches of various configurations.Materials and methods. The method uses reconstructed models of a healthy blood vessel obtained from a preoperative computed tomography (CT) study of the affected blood vessel of a particular patient. Flow in the vessel is simulated by computational fluid dynamics using data from the patient's ultrasonic Doppler velocimetry and CT angiography. Risk factors are assessed by hemodynamic indices at the vessel wall associated with Wall Shear Stress (WSS).Results. We used the proposed method to study the hemodynamic results of 10 virtual CEA operations with patches of various shapes on a reconstructed healthy artery of a particular patient. The reason for patch implantation was to ensure that the vessel lumen is not narrowed as a result of the surgery, since closing the incision without a patch can reduce the vessel lumen circumference by 4–5 mm, which adversely affects blood flow. On the other hand, too wide a patch creates aneurysmorphic deformation of the internal carotid artery (ICA) mouth, which is not optimal due to formation of a large recirculation zone. In this case, it was found that the implanted patch width of about 3 mm provides an optimal hemodynamic outcome. Deviations from this median value, both upward and downward, impair hemodynamics. The absence of a patch gives the worst of the results considered.Conclusion: The proposed computer modeling technique is able to provide a personalized patch selection for classical CEA with low risk of restenosis in the long-term follow-up.
Evaluation of cardiovascular comorbidity in cancer patients and analysis of potential risk factors for cardiovascular complications of checkpoint inhibitor therapy
Authors: Kushnareva E. A. , Shuginova T. N. 
Published: January 2022

Aim. To analyze the spectrum of cancer types and baseline cardiovascular comorbidity in patients receiving checkpoint inhibitor therapy.Material and methods. We performed retrospective analysis of case records of 112 cancer patients (55 men and 57 women) who received checkpoint inhibitor therapy in St. Petersburg hospitals. We analyzed primary tumor localizations, received immunotherapy and the initial comorbid conditions in patients.Results. The mean age of patients at the time of anticancer therapy initiation was 59,7±12,1 years for men, 57,7±14,1 years for women (p=0,249). The most common indications for immunotherapy were the following localizations: melanoma (34,8%), lungs (21,4%) and urinary system (12,5%). Among women who received checkpoint inhibitors, the lung and gynecologic cancer had the same prevalence (17,5%). The vast majority of patients (85,7%) received antiPD-1 agents, while the anti-CTLA4+anti-PD-1 combination was received by only 8,6% of patients, anti-PD-L1 monotherapy — 5,7%. Before anticancer therapy initiation, 69,6% of patients had prior CVD and/or risk factors. There were following most common comorbid conditions: hypertension — 58,9%, coronary artery disease — 36,6%, heart failure — 24,1%. At the same time, men in comparison with women were more likely to have prior stroke (12,7% vs 1,75%, respectively, p=0,024). There were no other significant sex differences between the incidence of cardiovascular diseases.Conclusion. Based on current publications describing potential risk factors for cardiovascular complications of cancer immunotherapy with checkpoint inhibitors, among the patients included in this study, 87,5% of patients can be attributed to the high-risk group.
Optimization of blood pressure control, organ protection and metabolic disorders using a fixed-dose combination of lisinopril+amlodipine+rosuvastatin in hypertensive patients after COVID-19
Authors: Nedogoda S. V. , Ledyaeva A. A. , Chumachek E. V. , Tsoma V. V. , Salasyuk A. S. , Lutova V. O. , Popova E. A. , Vlasov D. S. , Bychkova O. I. , Labaznikova V. A. , Evdokimov K. S. 
Published: January 2022

Aim. To evaluate the potential of a fixed-dose combination of lisinopril+amlodipine+rosuvastatin (Equamer®) in achieving additional vascular protection in patients with hypertension and high pulse wave velocity (PWV) after severe and very severe coronavirus disease 2019 (COVID-19), complicated by bilateral multisegmental viral pneumonia, with the use of biological therapy, who had not previously received combination antihypertensive therapy.Material and methods. This 12-week open-label observational study included 30 patients with or without antihypertensive therapy. The patients underwent 24-hour blood pressure monitoring, applanation tonometry (determination of the augmentation index (AI) and central blood pressure (CBP)), PWV measurement, blood laboratory tests (lipid profile, fasting glucose, C-reactive protein, complete blood count, ferritin, fibrinogen, D-dimer, alanine aminotransferase, aspartate aminotransferase, creatinine, uric acid) before and after switch to a fixed-dose combination of lisinopril+amlodipine+rosuvastatin.Results. At baseline, the patients had an increase in office blood pressure (BP) up to 152,6/89,1 mm Hg. After prescribing a fixed-dose combination of lisinopril+amlodipine+rosuvastatin, there was a decrease in systolic blood pressure (SBP) by 15,8% and diastolic blood pressure (DBP) by 12,2%. According to 24-hour blood pressure monitoring, the decrease in SBP was 15%, DBP — by 9%, PWV — by 23,8%, AI — by 9%, CBP — by 12,4% (p<0,05 for all compared to baseline values). Vascular age (VA) was initially increased to 41,9 years with a chronological age of 35,03 years. After the end of therapy, there was a significant decrease in VA to 36,5 years, low-density lipoproteins by 46,8%, triglycerides by 16,8% and an increase in high-density lipoproteins by 10,7% (p<0,05 for all compared to baseline values). In addition, the levels of C-reactive protein, fibrinogen, D-dimer, glucose, and uric acid significantly decreased.Conclusion. The fixed-dosed combination of lisinopril+amlodipine+rosuvastatin provides better blood pressure control, improved vascular elasticity parameters (AI, PWV, CBP, decrease in VA), and also improves lipid and carbohydrate metabolism, reduces inflammation in patients with hypertension and hyperlipidemia after severe COVID-19.
Evaluation of the effect of the use of the drug ticagrelor in patients with acute coronary syndrome on achieving the target indicator “reduction of mortality from diseases of the circulatory system” in 2022-2024
Authors: Zhuravleva M. V. , Zyryanov S. K. , Paleev F. N. , Yakovlev A. N. , Marin T. V. , Gagarina Yu. V. 
Published: January 2022

Aim. To evaluate the effect of the use of the double antiplatelet therapy (DAT) with ticagrelor compared to DAT with clopidogrel and antithrombotic therapy with acetyl salicylic acid (ASA) in patients with acute coronary syndrome and patients with high coronary risk on the target indicator (CP) of the state program (GP) “Development of Healthcare” and the federal project “Fight against cardiovascular diseases” — reducing mortality from diseases of the circulatory system (BSC).Material and methods. All adult Russian patients with a diagnosis of ACS eligible for DAT were considered as the target population; in the second and third years, only patients with high coronary risk continued treatment. The calculation of the number of deaths that can be prevented using DAT ticagrelor 90 mg + ASA vs DAT of clopidogrel + ASA within 1st year from the date of diagnosis was based on the clinical efficacy data of the PLATO study. The number of deaths that can be prevented with the use of DAT ticagrelor 60 mg + ASA — instead of ASA monotherapy patients with a history of myocardial infarction was made based in the clinical efficacy results of the PEGASUS study. It was calculated what proportion of the target indicators could be achieved in 2022-24 years by using DAT with ticagrelor instead of clopidogrel or ASA monotherapy.Results. The use of DAT with ticagrelor vs DAT with clopidogrel or ASA for the treatment of patients with ACS will prevent additional 5389, 5704 and 6012 deaths in 2022-2024, that will ensure the implementation of the CP “reduction of mortality from BSC” GP “Development of healthcare” in the Russian Federation by 36,9%, 26,0% and 20,6% respectively.Conclusion. The use of DAT with ticagrelor for the treatment of patients with acute coronary syndrome ensure the implementation of the CP “reduction of mortality from BSC” GP “Development of healthcare” in the Russian Federation in 2024 by 20,6%.
Yiga Kaka (Cock Diagnosis)
Authors: Hamadama Aboubakar 
Published: January 2022

In a small village in Northern Cameroon; lives a respected Mboum head of the family with his many children. The latter practices the Yiga kaka or Cockrel diagnosis where he earns his living by making the diagnosis and curing the sick through a cockrel. This practice allows the Yiga kaka practitioner to identify what the patient is suffering from and provide care. In this socioculture, only the initiated practitioner mastering the codes and the necessary knowledge can exercise this profession. Despite the influence of modernity, Alim Sardi strives to perpetuate this practice.
Awoudou Ways of Seeing
Authors: Tezore Amandine 
Published: January 2022

Les attaques de Boko Haram ont poussées plusieurs habitants des zones frontalières du Cameroun et du Nigeria à désertés leurs villages natal. C’est ainsi que toute la famille D’Awoudou fut décimée pendant les attaques de Boko Haram à Kolofata en 2016. Il eu la vie sauve grâce au voyage effectué ce jour pour l’achat de ses marchandises. Ainsi, cette nuit Boko Haram ôta sa dignité, sa famille, son autonomie financière et au delà de toute expérience, sa vue. « Awoudou ways of seeing » est un film sur la vie quotidienne d’Awoudou dans le camp de Zamai, Mayo Tsanaga, Cameroun. Il révèle son combat continu pour sa survie malgré les différents dilemmes. Son enthousiasme pour la survie va au delà de son handicape. Il a su créer des relations qui le lient à la population. Créant ainsi une lueur d’espoir, de joie et des épaules sur qui comptés. Malheureusement, l’appartenance à un autre groupe ethnique et religieux ne facilite pas son admission dans le camp.
Married at 13, 13 Years Ago
Authors: Bako Moustapha 
Published: January 2022

Synopsis (English) :
When Ammiya was 13 years old, while in her 6th year at school, her parents sent her to marriage without her consent. As is customary in the Fulani and Muslim communities in Cameroon, no one tried to stop this marriage. Ammiya was hindered in continue her education, and to herself choose her husband. 13 years after her wedding, now divorced, she looks back and tell her story.

Synopsis (French):
A 13 ans, ses parents l’envoient en mariage sans son consentement, alors qu’elle préparait le concours d’entrée en 6e et le CEPE. Comme de coutume dans la communauté peule et musulmane, aucune voix ne s’est levée pour empêcher ce mariage afin que l’adolescente Ammiya continue ses études, choisir son mari et le moment de se marier plus tard. 13 ans après son mariage, elle nous fait le bilan de ses 13 ans de mariage.
Evidence-Based Approach in Management: Evidence-Based Management and Policy
Authors: Semya G.V. , Stanilevsky V.V. , Gazaryan A.A. , Nekrasov A.S. 
Published: January 2022

Objective. Review of the concepts of “evidence-based approach in management”, “evidence-based management”, and “evidence-based policy”. Systematization of factors that inhibit and contribute to the dissemination of evidence-based management practices in the social sphere. Identification of priority measures to support the development of an evidence-based approach in the management in the social sphere.Background. Executives in general, and also in the social sphere, are facing challenges of an increasing level of uncertainty, which brings difficulties to make reliable forecasts and make decisions with guaranteed results. At the same time, there is a systemic crisis of resources, requiring the choice of strategies and tactics that provide the highest level of performance. An additional challenge is the increasing amount of operations and the emerging need for managers to make quick management decisions. Against this background, the evidence-based approach acquires particular importance, based on the idea of the need to rely on the findings of research and expertise, providing managers with relevant data for choosing certain areas of action.Methodology. Literature review.Conclusions. The evidence-based approach in management is a range of practices with various severity of requirements, connected by the need for evidence-based and expert data for decision-making. Evidence-based management is a process of implementing an evidence-based approach within the framework of the activities of different level managers. Evidence-based policy is the implementation of evidence-based principles in making political decisions. Promotion of the evidence-based approach in management encounters several barriers such as assessment, used methodology, finance. However, some conditions can positively influence its promotion among practitioners: the involvement of senior managers, specialized training, the convergence of practitioners and researchers, and other factors. The funding of research and its accessibility remains critical.
Photographic reading aloud
Authors: Osipov Viktor P. 
Published: January 2022

The morbid disorder, which we characterize by the term photographic reading aloud, is so peculiar that although we have mentioned it in our work on catatonia, we nevertheless consider it proper to consider this disorder in more detail in a separate article; at a meeting of the Society of Neurologists and Psychiatrists at the Imperial Kazan University on October 22, 1907, we made a presentation on the aforementioned disorder and could exchange opinions with our comrades in the specialty about the origin of the painful phenomenon that interests us.
Here is the story of a patient who was under our supervision.