bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity and efficacy of fourth BNT162b2 and mRNA1273 COVID-19 vaccine doses; three months follow-up
Authors: Canetti Michal , Barda Noam , Gilboa Mayan , Indenbaum Victoria , Mandelboim Michal , Gonen Tal , Asraf Keren , Weiss-Ottolenghi Yael , Amit Sharon , Doolman Ram , Mendelson Ella , Harats Dror , Freedman Laurence S. , Kreiss Yitshak , Lustig Yaniv , Regev-Yochay Gili 
Published: December 2022

AbstractBooster doses for the ongoing COVID-19 pandemic are under consideration in many countries. We report a three-month follow-up of 700 participants in a fourth vaccine dose study, comparing BNT162b2 and mRNA1273, administered four months after a third BNT162b2 dose. The primary outcomes are the levels of IgG, neutralizing antibodies, and microneutralization and the secondary outcomes are the levels of IgA and T cell activation, and clinical outcomes of SARS-CoV-2 infection and substantial symptomatic disease. Waning of the immune response is evident during follow-up, with an 11% (β = 0.89, 95% CI, 0.88–0.9) and 21% (β = 0.79, 95% CI, 0.76–0.82) multiplicative decay per week of IgG and neutralizing antibodies, respectively, in the mRNA1273 group, and of 14% (β = 0.86, 95% CI, 0.86–0.87) and 26% (β = 0.74, 95% CI, 0.72–0.76), respectively, in the BNT162b2 group. Direct neutralization of Omicron variants is low relative to ancestral strains. Cumulatively over the study period, both vaccines show little efficacy against infection but were highly efficacious against substantial symptomatic disease [89% [(IRR 0.11, 95% CI, 0.02–0.37) and 71% (IRR 0.29, 95% CI, 0.13–0.57) for mRNA1273 and BNT162b2, respectively]. These results are informative for further boosting policy-making. Trial registration numbers (clinicaltrials.gov): NCT05231005 and NCT05230953.
Direct visualization of edge state in even-layer MnBi2Te4 at zero magnetic field
Authors: Lin Weiyan , Feng Yang , Wang Yongchao , Zhu Jinjiang , Lian Zichen , Zhang Huanyu , Li Hao , Wu Yang , Liu Chang , Wang Yihua , Zhang Jinsong , Wang Yayu , Chen Chui-Zhen , Zhou Xiaodong , Shen Jian 
Published: December 2022

AbstractBeing the first intrinsic antiferromagnetic (AFM) topological insulator (TI), MnBi2Te4 is argued to be a topological axion state in its even-layer form due to the antiparallel magnetization between the top and bottom layers. Here we combine both transport and scanning microwave impedance microscopy (sMIM) to investigate such axion state in atomically thin MnBi2Te4 with even-layer thickness at zero magnetic field. While transport measurements show a zero Hall plateau signaturing the axion state, sMIM uncovers an unexpected edge state raising questions regarding the nature of the “axion state”. Based on our model calculation, we propose that the edge state of even-layer MnBi2Te4 at zero field is derived from gapped helical edge states of the quantum spin Hall effect with time-reversal-symmetry breaking, when a crossover from a three-dimensional TI MnBi2Te4 to a two-dimensional TI occurs. Our finding thus signifies the richness of topological phases in MnB2Te4 that has yet to be fully explored.
Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner
Authors: Wang Kun , Wang Muyun , Liao Ximing , Gao Shaoyong , Hua Jing , Wu Xiaodong , Guo Qian , Xu Wujian , Sun Jiaxing , He Yanan , Li Qiang , Gao Wei 
Published: December 2022

AbstractAcute respiratory distress syndrome (ARDS) is a common respiratory critical syndrome with no effective therapeutic intervention. Neutrophils function in the overwhelming inflammatory process of acute lung injury (ALI) caused by ARDS; however, the phenotypic heterogeneity of pulmonary neutrophils in ALI/ARDS remains largely unknown. Here, using single-cell RNA sequencing, we identify two transcriptionally and functionally heterogeneous neutrophil populations (Fth1hi Neu and Prok2hi Neu) with distinct locations in LPS-induced ALI mouse lungs. Exposure to LPS promotes the Fth1hi Neu subtype, with more inflammatory factors, stronger antioxidant, and decreased apoptosis under the regulation of interleukin-10. Furthermore, prolonged retention of Fth1hi Neu within lung tissue aggravates inflammatory injury throughout the development of ALI/ARDS. Notably, ARDS patients have high ratios of Fth1 to Prok2 expression in pulmonary neutrophils, suggesting that the Fth1hi Neu population may promote the pathological development and provide a marker of poor outcome.
Inferring time-varying generation time, serial interval, and incubation period distributions for COVID-19
Authors: Chen Dongxuan , Lau Yiu-Chung , Xu Xiao-Ke , Wang Lin , Du Zhanwei , Tsang Tim K. , Wu Peng , Lau Eric H. Y. , Wallinga Jacco , Cowling Benjamin J. , Ali Sheikh Taslim 
Published: December 2022

AbstractThe generation time distribution, reflecting the time between successive infections in transmission chains, is a key epidemiological parameter for describing COVID-19 transmission dynamics. However, because exact infection times are rarely known, it is often approximated by the serial interval distribution. This approximation holds under the assumption that infectors and infectees share the same incubation period distribution, which may not always be true. We estimated incubation period and serial interval distributions using 629 transmission pairs reconstructed by investigating 2989 confirmed cases in China in January-February 2020, and developed an inferential framework to estimate the generation time distribution that accounts for variation over time due to changes in epidemiology, sampling biases and public health and social measures. We identified substantial reductions over time in the serial interval and generation time distributions. Our proposed method provides more reliable estimation of the temporal variation in the generation time distribution, improving assessment of transmission dynamics.
Revenue loss due to whale entanglement mitigation and fishery closures
Authors: Seary Rachel , Santora Jarrod A. , Tommasi Desiree , Thompson Andrew , Bograd Steven J. , Richerson Kate , Brodie Stephanie , Holland Dan 
Published: December 2022

AbstractWhale entanglements with fishing gear, exacerbated by changing environmental conditions, pose significant risk to whale populations. Management tools used to reduce entanglement risk, for example temporary area restrictions on fishing, can have negative economic consequences for fishing communities. Balancing whale protection with sustaining productive fisheries is therefore a challenge experienced worldwide. In the California Current Ecosystem, ecosystem indicators have been used to understand the environmental dynamics that lead to increased whale entanglement risk in a lucrative crab fishery. However, an assessment of socio-economic risk for this fishery, as in many other regions, is missing. We estimate retrospectively the losses from ex-vessel revenue experienced by commercial Dungeness crab fishers in California during two seasons subject to whale entanglement mitigation measures using a Linear-Cragg hurdle modeling approach which incorporated estimates of pre-season crab abundance. In the 2020 fishing season, our results suggest total revenues would have been $14.4 million higher in the Central Management Area of California in the absence of closures and other disturbances. In the 2019 fishing season, our results suggest ex-vessel revenues would have been $9.4 million higher in the Central Management Area and $0.3 million higher in the Northern Management Area. Our evaluation should motivate the development of strategies which maximize whale protection whilst promoting productive, sustainable and economically-viable fisheries.
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model
Authors: Cornet Sylvie , Carré Denis , Limana Lorenzo , Castel David , Meilin Sigal , Horne Ron , Pons Laurent , Evans Steven , Lezmi Stephane , Kalinichev Mikhail 
Published: December 2022

AbstractPain after surgery remains a significant healthcare challenge. Here, abobotulinumtoxinA (aboBoNT-A, DYSPORT) was assessed in a post-surgical pain model in pigs. Full-skin-muscle incision and retraction surgery on the lower back was followed by intradermal injections of either aboBoNT-A (100, 200, or 400 U/pig), vehicle (saline), or wound infiltration of extended-release bupivacaine. We assessed mechanical sensitivity, distress behaviors, latency to approach the investigator, and wound inflammation/healing for 5–6 days post-surgery. We followed with immunohistochemical analyses of total and cleaved synaptosomal-associated protein 25 kD (SNAP25), glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor protein-1(Iba1), calcitonin gene-related peptide (CGRP) and substance P (SP) in the skin, dorsal root ganglia (DRG) and the spinal cord of 400 U aboBoNT-A- and saline-treated animals. At Day 1, partial reversal of mechanical allodynia in aboBoNT-A groups was followed by a full reversal from Day 3. Reduced distress and normalized approaching responses were observed with aboBoNT-A from 6 h post-surgery. Bupivacaine reversed mechanical allodynia for 24 h after surgery but did not affect distress or approaching responses. In aboBoNT-A-treated animals cleaved SNAP25 was absent in the skin and DRG, but present in the ipsilateral dorsal horn of the spinal cord. In aboBoNT-A- versus saline-treated animals there were significant reductions in GFAP and Iba1 in the spinal cord, but no changes in CGRP and SP. Analgesic efficacy of aboBoNT-A appears to be mediated by its activity on spinal neurons, microglia and astrocytes. Clinical investigation to support the use of aboBoNT-A as an analgesic drug for post-surgical pain, is warranted.
Overexpression of hepatocyte EphA2 enhances liver-stage infection by Plasmodium vivax
Authors: Chainarin Sittinont , Jaihan Ubonwan , Tapaopong Parsakorn , Kongngen Pinyapat , Kunkeaw Nawapol , Cui Liwang , Sattabongkot Jetsumon , Nguitragool Wang , Roobsoong Wanlapa 
Published: December 2022

AbstractThe liver is the first destination of malaria parasites in humans. After reaching the liver by the blood stream, Plasmodium sporozoites cross the liver sinusoid epithelium, enter and exit several hepatocytes, and eventually invade a final hepatocyte host cell. At present, the mechanism of hepatocyte invasion is only partially understood, presenting a key research gap with opportunities for the development of new therapeutics. Recently, human EphA2, a membrane-bound receptor tyrosine kinase, was implicated in hepatocyte infection by the human malaria parasite Plasmodium falciparum and the rodent parasite Plasmodium yoelii, but its role is not known for Plasmodium vivax, a major human parasite whose liver infection poses a specific challenge for malaria treatment and elimination. In this study, the role of EphA2 in P. vivax infection was investigated. It was found that surface expression of several recombinant fragments of EphA2 enhanced the parasite infection rate, thus establishing its role in P. vivax infection. Furthermore, a new permanent cell line (EphA2Extra-HC04) expressing the whole extracellular domain of EphA2 was generated. This cell line supports a higher rate of P. vivax infection and is a valuable tool for P. vivax liver-stage research.
Association of cerebral white matter hyperintensities with coronary artery calcium in a healthy population: a cross-sectional study
Authors: Choi Jinyoung , Kim Jung Youn , Kwon Heon-Ju , Choi Hye Jeong , Kim Sang Heum , Kim Sinae , Lee Jungbin , Park Ji Eun 
Published: December 2022

AbstractIn brain magnetic resonance imaging (MRI), white matter hyperintensity (WMH) is a commonly encountered finding and is known to reflect cerebral small vessel disease. The aim of our study was to investigate the association of coronary artery calcium (CAC) with WMH and elucidate the relationship between WMH and atherosclerotic risk factors in a large-scale healthy population. This retrospective study included 1337 individuals who underwent brain MRI and CAC scoring computed tomography at healthcare centers affiliated with a tertiary hospital. Cerebral WMH was defined as Fazekas score greater than 2 on brain MRI. Intracranial artery stenosis (ICAS) was also assessed and determined to be present when stenosis was more than 50% on angiography. The associations of risk factors, CAC score, and ICAS with cerebral WMH were assessed by multivariable regression analysis. In multivariable analysis, categories of higher CAC scores showed increased associations with both periventricular and deep WMHs in a dose-dependent relationship. The presence of ICAS was also significantly related to cerebral WMH, and among the clinical variables, age and hypertension were independent risk factors. In conclusion, CAC showed a significant association with cerebral WMH in a healthy population, which might provide evidence for referring to the CAC score to identify individuals with risk of cerebral WMH.
Validation of the Japanese version of the Body Image Scale for bladder cancer patients
Authors: Sato Miho , Osawa Takahiro , Abe Takashige , Honda Michitaka , Higuchi Madoka , Yamada Shuhei , Furumido Jun , Kikuchi Hiroshi , Matsumoto Ryuji , Sato Yasuyuki , Sasaki Yoshihiro , Harabayashi Toru , Maruyama Satoru , Takada Norikata , Minami Keita , Tanaka Hiroshi , Morita Ken , Kashiwagi Akira , Murai Sachiyo , Ito Yoichi M. , Ogasawara Katsuhiko , Shinohara Nobuo 
Published: December 2022

AbstractThe Body Image Scale (BIS) is a 10-item tool that measures the body images of cancer patients. This study aims to validate the Japanese version of the BIS for bladder cancer patients. A multicenter cross-sectional survey was used to identify the participants, which included Japanese bladder cancer patients. The percentage of missing responses, internal consistency, and known-group validity were evaluated. The correlations between the BIS and two HRQOL instruments (the Bladder Cancer Index and the SF-12) were assessed to determine convergent validity. Among 397 patients, 221 patients were treated by transurethral resection of bladder tumor (TURBT) endoscopically, 49 patients underwent cystectomy with neobladder, and 127 patients underwent cystectomy involving stoma. The percentage of missing responses in the BIS ranged from 8.1 to 15.6%. Cronbach's α coefficient was 0.924. Higher BIS scores indicate negative body image, and the median BIS score for patients with native bladders after TURBT (0.5) was significantly lower than those of the patients with neobladder (4.0) and stoma formation (7.0), which indicated the discriminatory ability of the BIS. Each domain of the Bladder Cancer Index and the role summary score of the SF-12 correlated to the BIS scores, which confirmed the convergent validity. A range of BIS scores were identified among patients who reported similar physical summary scores and mental summary scores of the SF-12. This study confirmed the reliability and validity of the Japanese version of the BIS for bladder cancer patients.
Glial Bmal1 role in mammalian retina daily changes
Authors: Riccitelli Serena , Boi Fabio , Lonardoni Davide , Giantomasi Lidia , Barca-Mayo Olga , De Pietri Tonelli Davide , Bisti Silvia , Di Marco Stefano , Berdondini Luca 
Published: December 2022

AbstractVisual information processing in the retina requires the rhythmic expression of clock genes. The intrinsic retinal circadian clock is independent of the master clock located in the hypothalamic suprachiasmatic nucleus and emerges from retinal cells, including glia. Less clear is how glial oscillators influence the daily regulation of visual information processing in the mouse retina. Here, we demonstrate that the adult conditional deletion of the gene Bmal1 in GLAST-positive glial cells alters retinal physiology. Specifically, such deletion was sufficient to lower the amplitude of the electroretinogram b-wave recorded under light-adapted conditions. Furthermore, recordings from > 20,000 retinal ganglion cells (RGCs), the retina output, showed a non-uniform effect on RGCs activity in response to light across different cell types and over a 24-h period. Overall, our results suggest a new role of a glial circadian gene in adjusting mammalian retinal output throughout the night-day cycle.
Intelligent prediction models based on machine learning for CO2 capture performance by graphene oxide-based adsorbents
Authors: Fathalian Farnoush , Aarabi Sepehr , Ghaemi Ahad , Hemmati Alireza 
Published: December 2022

AbstractDesigning a model to connect CO2adsorption data with various adsorbents based on graphene oxide (GO) which is produced from various forms of solid biomass, can be a promising method to develop novel and efficient adsorbents for CO2adsorption application. In this work, the information of several GO-based solid sorbents were extracted from 17 articles aimed to develop a machine learning based model for CO2adsorption capacity prediction. The extracted data including specific surface area, pore volume, temperature, and pressure were considered as input parameter, and CO2uptake capacity was defined as model response, alsoseven different models, including support vector machine, gradient boosting, random forest, artificial neural network (ANN) based on multilayer perceptron (MLP) and radial basis function (RBF), Extra trees regressor and extreme gradient boosting, were employed to estimate the CO2adsorption capacity. The best performance was obtained for ANN based on MLP method (R2 > 0.99) with hyperparameters of the following: hidden layer size = [45 35 45 45], optimizer = Adam, the learning rate = 0.003,β1 = 0.9,β2 = 0.999, epochs = 1971, and batch size = 32. To investigate CO2uptake dependency on mentioned effective parameters, three dimensional diagrams were reported based on MLP network, also the MLP network characteristics including weight and bias matrices were reported for further application of CO2adsorption process design. The accurately predicted capability of the generated models may considerably minimize experimental efforts, such as estimating CO2removal efficiency as the target based on adsorbent properties to pick more efficient adsorbents without increasing processing time. Current work employed statistical analysis and machine learning to support the logical design of porous GO for CO2separation, aiding in screening adsorbents for cleaner manufacturing.
Short- and long-term effects of an electronic medication management system on paediatric prescribing errors
Authors: Westbrook Johanna I. , Li Ling , Raban Magdalena Z. , Mumford Virginia , Badgery-Parker Tim , Gates Peter , Fitzpatrick Erin , Merchant Alison , Woods Amanda , Baysari Melissa , McCullagh Cheryl , Day Ric , Gazarian Madlen , Dickinson Michael , Seaman Karla , Dalla-Pozza Lucciano , Ambler Geoffrey , Barclay Peter , Gardo Alan , O’Brien Tracey , Barbaric Draga , White Les 
Published: December 2022

AbstractElectronic medication management (eMM) systems are designed to improve safety, but there is little evidence of their effectiveness in paediatrics. This study assesses the short-term (first 70 days of eMM use) and long-term (one-year) effectiveness of an eMM system to reduce prescribing errors, and their potential and actual harm. We use a stepped-wedge cluster randomised controlled trial (SWCRCT) at a paediatric referral hospital, with eight clusters randomised for eMM implementation. We assess long-term effects from an additional random sample of medication orders one-year post-eMM. In the SWCRCT, errors that are potential adverse drug events (ADEs) are assessed for actual harm. The study comprises 35,260 medication orders for 4821 patients. Results show no significant change in overall prescribing error rates in the first 70 days of eMM use (incident rate ratio [IRR] 1.05 [95%CI 0.92–1.21], but a 62% increase (IRR 1.62 [95%CI 1.28–2.04]) in potential ADEs suggesting immediate risks to safety. One-year post-eMM, errors decline by 36% (IRR 0.64 [95%CI 0.56–0.72]) and high-risk medication errors decrease by 33% (IRR 0.67 [95%CI 0.51–0.88]) compared to pre-eMM. In all periods, dose error rates are more than double that of other error types. Few errors are associated with actual harm, but 71% [95%CI 50–86%] of patients with harm experienced a dose error. In the short-term, eMM implementation shows no improvement in error rates, and an increase in some errors. A year after eMM error rates significantly decline suggesting long-term benefits. eMM optimisation should focus on reducing dose errors due to their high frequency and capacity to cause harm.
Interaction of a high-mass X-ray binary with the interstellar medium through stellar wind
Authors: Marchioro J. , Chaty S. , Coleiro A. , Fortin F. , Simaz Bunzel A. 
Published: December 2022

Context. GX 301-2 is a high-mass X-ray binary (HMXB) with strong stellar outflows. The evolution of these binaries can be closely related with the interstellar environment due to strong wind interactions.
Aims. We try to constrain the energy injected in the interstellar medium by GX 301-2 through stellar wind using HAWK-I and Herschel data.
Methods. We analysed HAWK-I images in four different filters (Brγ, H2, J, and Ks) and tried to retrieve signatures of the impact of GX 301-2 on its environment. We used Herschel data to outline the interstellar medium and the Gala DR3 catalogue to infer the proper motion of GX 301-2. Finally, we estimated the energy injected in the interstellar medium since the first supernova event of the HMXB.
Results. Using both HAWK-I and Herschel images, we deduce an approximation of the total mass injected from GX 301-2 in the interstellar medium of Minj = 3.05-0.03+0.05 × 10-2 M⊙.
Characterization of Laboratory Flow and Performance for Process Improvements via Application of Process Mining
Authors: Tsai Eline R. , Tintu Andrei N. , Boucherie Richard J. , de Rijke Yolanda B. , Schotman Hans H.M. , Demirtas Derya 
Published: December 2022

Abstract
Background The rising level of laboratory automation provides an increasing number of logged events that can be used for the characterization of laboratory performance and process improvements. This abundance of data is often underutilized for improving laboratory efficiency.
Objectives The first aim of this descriptive study is to provide a structured approach for transforming raw laboratory data to data that is suitable for process mining. The second aim is to describe a process mining approach for mapping and characterizing the sample flow in a clinical chemistry laboratory to identify areas for improvement in the testing process.
Methods Data were extracted from instrument log files and the middleware between laboratory instruments and information technology infrastructure. Process mining was used for automated process discovery and analysis. Laboratory performance was quantified in terms of relevant key performance indicators (KPIs): turnaround time, timeliness, workload, work-in-process, and machine downtime.
Results The method was applied to two Dutch university hospital clinical chemistry laboratories. We identified areas where alternative routes might increase laboratory efficiency and observed the negative effects of machine downtime on laboratory performance. This encourages the laboratory to review sample routes in its analyzer lines, the routes of high priority samples during instrument downtime, as well as the preventive maintenance policy.
Conclusion This article provides the first application of process mining to event data from a medical diagnostic laboratory for automated process model discovery. Our study shows that process mining, with the use of relevant KPIs, provides valuable insights for laboratories that motivates the disclosure and increased utilization of laboratory event data, which in turn drive the analytical staff to intervene in the process to achieve the set performance goals. Our approach is vendor independent and widely applicable for all medical diagnostic laboratories.