bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reverse cardiac remodelling and dysfunction in A97S transthyretin cardiac amyloidosis after tafamidis treatment
Authors: Wu Yuan‐Kun (Aden) , Tsai Cheng‐Hsuan , Su Mao‐Yuan , Chao Chi‐Chao , Cheng Mei‐Fang , Shun Chia‐Tung , Hsieh Sung‐Tsang , Lin Yen‐Hung 
Published: September 2022

AbstractTransthyretin cardiomyopathy (ATTR‐CM) is an under‐recognized cause of heart failure, but it has received increasing attention due to the availability of treatment options. We present a case of hereditary transthyretin cardiomyopathy (A97S, an under‐represented variant in current clinical studies) who presented with heart failure. Timely diagnosis and intervention with tafamidis demonstrated reversed cardiac remodelling via multiple imaging techniques (echocardiography, cardiac magnetic resonance imaging and technetium‐99m pyrophosphate scintigraphy). The echocardiography and cardiac magnetic resonance imaging demonstrated improved global strain. Cardiac magnetic resonance imaging showed decreased extracellular volume. The technetium‐99m pyrophosphate scintigraphy demonstrated decreased heart‐to‐contralateral ratio. This case highlights the potential reversible effect of tafamidis on A97S amyloidosis cardiomyopathy.
Method to describe the distribution of wind velocity and its application in wind resource evaluation
Authors: Zhou Hai , Hu Siyu , Wu Ji , Qin Fang , Li Dengxuan , Wei Haikun 
Published: September 2022

AbstractA convenient and effective method based on vector analysis was proposed in this paper to quantitatively describe the pattern of the wind speed distribution curve. This method can accurately describe the steepness of the single‐peak curve by using two parameters of concentration degree (CD) and concentration period (CP). Through the analysis of wind speed data in China over the past 40 years, this paper found that regional wind resources with larger CD were poorer, while regional wind resources with larger CP were richer. In addition, there were obvious cubic relationships between the CP and the average wind power density. These two parameters could reflect the richness of wind energy and realize the comparisons of wind resources across time and scales. In comparison with conventional approaches, this method is simpler and avoids fitting process, which has broad promotion prospects in the field of power grids.
Linking uplift, erosion, and sedimentation using landscape evolution models: Madagascar since the Late Cretaceous
Authors: Jiao Ruohong , Braun Jean , Delaunay Antoine , Robin Cécile , Guillocheau François 
Published: September 2022

SummaryWe present a study to estimate the large‐scale landscape history of a continental margin, by establishing a source‐to‐sink volume balance between the eroding onshore areas and the offshore basins. Assuming erosion as the primary process for sediment production, we strive to constrain a numerical model of landscape evolution that balances the volumes of eroded materials from the continent and that deposited in the corresponding basins, with a ratio imposed for loss of erosion products. We use this approach to investigate the landscape history of Madagascar since the Late Cretaceous. The uplift history prescribed in the model is inferred from elevations of planation surfaces formed at various ages. By fitting the volumes of terrigenous sediments in the Morondava Basin along the west coast and the current elevation of the island, the landscape evolution model is optimized by constraining the erosion law parameters and ratios of sediment loss. The results include a best‐fit landscape evolution model, which features two major periods of uplift and erosion during the Late Cretaceous and the middle to late Cenozoic. The model supports suggestions from previous studies that most of the high topography of the island was constructed since the middle to late Miocene, and on the central plateau the erosion has not reached an equilibrium with the high uplift rates in the late Cenozoic. Our models also indicate that over the geological time scale a significant portion of materials eroded from Madagascar was not archived in the offshore basin, possibly consumed by chemical weathering, the intensity of which might have varied with climate.
Two stage, hybrid endovascular and open surgical approach to treat difficult carotid body tumors
Authors: Fink‐Josephi Gustavo , Hurtado‐López Luis Mauricio , Hernández‐Valencia Aldo Francisco , Higuera‐Calleja Jesús Antonio , Guerrero‐Avendaño Guadalupe 
Published: September 2022

AbstractObjectivePresent the feasibility, applicability, clinical effectiveness, and results of complicated Shamblin II or III carotid body tumors treated with a two‐stage hybrid surgical approach.Materials and MethodsRetrospective, observational, cross‐sectional, descriptive study of the successful treatment of 16 cases of difficult Shamblin II or III carotid body tumors, consisting of a two‐stage surgical approach. We conducted a retrospective, observational, cross‐sectional, descriptive study of a series of patients with complicated Shamblin II or III carotid body tumors, which we treated with a two‐stage hybrid surgical procedure, in which we first placed a carotid endoprosthesis and 45 days later performed surgical resection of the tumor, following our originally published technique. This study was conducted from February, 2007 to November, 2019, in a third level care centre.ResultsWe treated 16 patients with a mean age of 50.5 years. All resided at more than 2000 meters above sea level. In all 16 a complete resection was performed. The average duration of surgery was 103.9 min, the average intraoperative bleeding was 69 ml. There were three cases of neuropraxia. The ansa cervicalis nerve had to be sectioned in three cases and there was permanent upper laryngeal nerve injury in two cases. There were no permanent cerebrovascular injuries from placement of the endoprostheses. One patient developed transient cerebral ischaemia (TIA) with no long‐term sequelae. There were two cases of asymptomatic late occlusion of the endoprostheses. The average initial volume of the tumors was 54.4 cc. The average tumor volume 35 days after implant of the endoprosthesis was 30.9 cc.SymptomsPresence of tumors in the neck in all cases and two cases of dysphagia.ConclusionThis two‐stage hybrid technique allowed for the complete resection of difficult Shamblin II or III carotid body tumors, with one case of TIA and two with permanent upper laryngeal nerve injuries and without mortality.
Low postoperative lymphocyte count increases risk of progression in human papillomavirus associated oropharyngeal cancer
Authors: Yin Linda X. , Routman David M. , Day Courtney N. , Harmsen William S. , Haller Travis , Bartemes Kathleen , Price Daniel L. , Moore Eric J. , Foote Robert L. , Neben‐Wittich Michelle , Chintakuntlawar Ashish V. , Ma Daniel J. , Price Katharine A. , Van Abel Kathryn M. 
Published: September 2022

AbstractBackgroundWe aim to explore the prognostic role of absolute lymphocyte count (ALC) before, during, and after treatment on oncologic outcomes in human papillomavirus associated oropharyngeal cancer (HPV(+)OPSCC).MethodsRetrospective cohort at a tertiary center, 2006–2018. Multivariable Cox regressions were used to determine the effect of ALC on risk of progression. Univariate linear regression was performed to determine clinical factors associated with lower ALC.ResultsAll 197 patients underwent primary surgery. Mean (SD) ALC nadirs (×109 cells/L) were: baseline (N = 149): 1.69 (0.56); postoperative (N = 126): 1.58 (0.59); post‐RT (N = 141): 0.68 (0.35) and long‐term (N = 105): 0.88 (0.37). Lower baseline ALC nadir was associated with worse overall survival (HR 3.85, 95%CI: 1.03–14.29, p = 0.04). Lower postoperative ALC nadir was associated with higher risk of progression (HR 2.63, 95%CI: 1.04–6.67, p = 0.04).ConclusionsLower baseline ALC is associated with worse survival, whereas lower postoperative ALC is associated with increased risk of progression in surgically treated HPV(+)OPSCC.Level of Evidence3
From fears to recession? Time‐frequency risk contagion among stock and credit default swap markets during the COVID pandemic
Authors: Zhai Pengxiang , Wu Fei , Ji Qiang , Nguyen Duc Khuong 
Published: September 2022

AbstractThis study uses a high‐dimensional time‐frequency volatility spillover model to examine risk interactions across 32 global stock and credit default swap (CDS) markets during the coronavirus (COVID‐19) pandemic. Our empirical results mainly show that cross‐market risk spillovers between these two types of markets are rare over the whole crisis period. Adding CDS assets to the stock portfolio would significantly decrease the overall risk spillovers in the mixed portfolio. Then, the time‐frequency spillover and rolling window analyses confirm this finding and provide further evidence of frequency heterogeneity of risk spillovers during the pandemic. The outbreak of the COVID pandemic only sharply increases short‐term risk spillovers between the stock and sovereign CDS market but exerts insignificant impacts on the medium and long‐term cross‐market risk spillovers. Moreover, our results show that developed countries are net transmitters in the stock markets. In contrast, the emerging markets account for the most risk spillovers in sovereign CDS markets over the sample period, emphasizing the heterogenous adverse impacts of the pandemic across various countries and markets. Finally, we find that bailouts implemented by the US and EU central banks, though with heterogeneous impacts across frequencies, gradually enhance the confidence and resilience of investors in these markets.
Dynamic growth changes in fetal growth restriction using serial ultrasonographic biometry and umbilical artery doppler: The multicenter PORTO study
Authors: Cody Fiona , Unterscheider Julia , Daly Sean , Geary Michael , Kennelly Mairead , McAuliffe Fionnuala , Morrison John , O'Donoghue Keelin , Hunter Alyson , Dicker Patrick , Tully Elizabeth , Fhearaigh Rachel , Malone Fergal ,   for the Perinatal Ireland Research Consortium
Published: September 2022

AbstractObjectiveTo describe the growth dynamics of fetuses with initial fetal growth restriction (FGR) later outgrowing the 10th centile for estimated fetal weight with respect to perinatal outcomes and maternal factors.MethodsA multicenter prospective study recruited 1116 patients for ultrasound surveillance between 2010 and 2012. All pregnancies were growth‐restricted singleton gestations between 24 + 0 and 36 + 0 weeks. Biometry and Doppler analysis were carried out, and delivery and adverse perinatal outcomes were recorded.ResultsA total of 193 (17%) fetuses outgrew their diagnosis of initial FGR (surpassed the 10th centile) on their last sonogram before delivery. These fetuses were termed “growers,” to compare with the true FGR group. The mothers of “growers” were less likely to be smokers (14% vs 25%, P = 0.0001) or affected by hypertensive pregnancy complications (5.2% vs 15%, P = 0.001). Of the growers, 49 (25%) had an abnormal umbilical artery Doppler; however, in most cases (33/49, 67%), this was a single episode of raised umbilical artery pulsatility index, which subsequently normalized.ConclusionThere were dynamic growth changes in FGR fetuses, with 17% outgrowing their original diagnosis. Positive growth spurts more commonly occurred in healthy mothers. Once a fetus had outgrown the 10th centile, antenatal surveillance could be decreased.
On closed‐shell interactions between heavy main‐group elements
Authors: Kloo Lars 
Published: September 2022

AbstractA series of di‐ and polymetal complexes involving closed‐shell, heavy main‐group atoms and ions shows a selection of special physical properties. These involve short metal–metal contacts, low entropies of formation and, most interestingly, strong Raman bands at low wavenumbers. These results together with the constitution of the coordination compounds, where the majority of electrons are assembled on the highly polarizable metal atoms and ions, experimental results have been interpreted in terms of direct, partial covalent metal–metal bonding. Previous theoretical studies have challenged this view and instead attributed the obvious attractive forces involved to secondary‐type of interactions, such as dispersion. This study utilizes a multitude of theoretical tools, such as natural bond order (NBO) and natural energy decomposition analysis (NEDA), non‐covalent interaction (NCI) analysis, electron localization functions (ELFs), and atoms‐in‐molecules (AIM) to characterize the interactions in models comprising closed‐shell dimers, as well as experimentally studied ring and cage systems constituting the main reason for the hypotheses on metal–metal interactions. The results show that all experimental results can be attributed to the covalent interactions between the electron‐rich, metal centers and the bridging anions in ring and cage coordination compounds of high symmetry, where the experimentally observed effects can be traced to the combination of covalent interactions between the metal centers and the anions along the edges of the ring and cage systems in combination with the cooperative effects generated by the high symmetry of these ring and cage systems.
Ultrasound features and preoperative accuracy of the fine needle aspiration biopsy in detection of thyroid carcinomas
Authors: Makazlieva Tanja , Stoilovska Rizova Bojana , Stojanoski Sinisa , Manevska Nevena , Vaskova Olivija , Velikj Stefanovska Vesna , Miladinova Daniela 
Published: September 2022

AbstractObjectiveTo analyze the ultrasound (US) characteristics and fine needle biopsy (FNAB) of thyroid carcinomas (TCs) prior to surgery and compare with postoperative histopathology and to determine FNAB sensitivity and specificity.Material and MethodsRetrospective analysis of the US data during 1999–2015 was performed, as well as analysis of FNAB results and using histopathology report as “gold standard” the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of this method was evaluated.ResultsData revealed that tumors >51 mm were declining by 50% in the period 2011–2015 compared to 2005–2010 or by 18% 2011–2015 compared to 1999–2004 and significant increase was detected in diagnosis of multicentric tumors. The analysis revealed that FNAB has sensitivity = 65.7% CI (0.59% ‐ 0.71%) and specificity = 50% CI (0.43%–0.56%), PPV = 56.9% and NPV = 59.2%.ConclusionWe found increasing detection of smaller TCs, as well as more frequent detection of multicentricity of the neoplastic foci. FNAB results in our study revealed low sensitivity and specificity. Major limitation of the study was inability to exactly separate US guided from non US guided FNAB in evaluation of the sensitivity and specificity, due to retrospective nature of the analysis. Further studies evaluating only US guided FNAB should be performed.
Aversive memory reactivation: A possible role for delta oscillations in the hippocampus–amygdala circuit
Authors: Couto Pereira Natividade de Sá , Klippel Zanona Querusche , Pastore Bernardi Marcelo , Alves Joelma , Dalmaz Carla , Calcagnotto Maria Elisa 
Published: September 2022

AbstractMemory labilization, the process by which memories become susceptible to update, is essential for memory reconsolidation and has been a target for novel therapies for traumatic memory‐associated disorders. Maternal separation (MS) in male rats produced memories resistant to labilization in adulthood. Based on previous results, we hypothesized that temporal desynchronization between the dorsal hippocampus (DHc) and the basolateral amygdala (BLA), during memory retrieval, could be responsible for this impairment. Our goal was to investigate possible differences in oscillatory activity and synchrony between the DHc and BLA during fear memory reactivation, between MS and non‐handled (NH) rats. We used male adult Wistar rats, NH or MS, with electrodes for local field potential (LFP) recordings implanted in the DHc and BLA. Animals were submitted to aversive memory reactivation by exposure to the conditioned context (Reat) or to pseudo‐reactivation in a neutral context (pReat), and LFP was recorded. Plasticity markers linked to reconsolidation were evaluated one hour after reactivation. The power of delta oscillations and DHc‐BLA synchrony in Reat animals was increased, during freezing. Besides, delta modulation of gamma oscillations amplitude in the BLA was associated with the increase in DHc Zif268 levels, an immediate early gene specifically associated with reconsolidation. Concerning early life stress, we found lower power of delta and strength of delta‐gamma oscillations coupling in MS rats, compared to NH, which could explain the low Zif268 levels in a subgroup of MS animals. These results suggest a role for delta oscillations in memory reactivation that should be further investigated.
Long‐term survival following fungal catheter‐related bloodstream infection for patients with intestinal failure receiving home parenteral support
Authors: Bond Ashley , Kopczynska Maja , Conley Thomas , Teubner Antje , Taylor Michael , Abraham Arun , Pironi Loris , Lal Simon 
Published: September 2022

AbstractBackgroundA fungal‐related catheter‐related bloodstream infection (CRBSI) is less frequent than those induced by bacteria. In the past, a single episode of fungal CRBSI has been used as a marker of home parenteral nutrition (HPN) failure and thus a possible indication for intestinal transplantation.MethodsSurvival outcomes were assessed from a prospectively maintained database of patients initiated on HPN for underlying chronic intestinal failure between 1993 and 2018, with a censoring date of December 31, 2020. Cox regression was performed to assess predictors of mortality with univariable and multivariable analysis.ResultsA total of 1008 patients were included in the study, with a total of 1 364 595 catheter days. There were 513 CRBSI events recorded in 262 patients, equating to a CRBSI rate of 0.38/1000 catheter days. A total of 38/262 (14.5%) patients had at least one episode of fungal CRBSI, whereas 216/262 (82.4%) had at least one bacterial but no fungal CRBSI. The median time between HPN initiation and the first CRBSI episode was 20.6 months (95% confidence interval, 16.5–24.1). Episodes of fungal or bacterial CRBSI and the number of CRBSI episodes were not associated with increased mortality. Overall, 15 CRBSI‐related deaths were observed in the observation period (0.01 CRBSI deaths/1000 catheter days), two of these were fungal in origin.ConclusionThe occurrence of a fungal CRBSI does not increase the risk of death compared with patients who have bacterial CRBSI or those without a CRBSI event.
Evolution and adoption of contributor role ontologies and taxonomies
Authors: Hosseini Mohammad , Colomb Julien , Holcombe Alex O. , Kern Barbara , Vasilevsky Nicole A. , Holmes Kristi L. 
Published: September 2022

AbstractContributor Role Ontologies and Taxonomies (CROTs) are standard vocabularies to describe individual contributions to a scholarly project or research output. Contributor Roles Taxonomy (CRediT) is one of the most widely used CROTs, and has been adopted by numerous journals to describe author's contributions, and recently formalized as a ANSI/NISO standard. Despite these developments, there is still much work left to be done to improve how CROTs are used across different research domains, research output types, and scholarly workflows. In this paper, we describe how CROTs could be extended to include roles from various disciplines in an ethical and inclusive manner. We explore potential approaches to apply CROTs to diverse research objects and various disciplines; as well as envision their integration into various scholarly workflows, such as promotion and tenure in academic institutions. Lastly, we discuss potential mechanisms for wide adoption and use. While acknowledging that improving current systems of attribution is a slow and iterative process, we believe that engaging the community in the evolution of CROTs will ultimately enhance the ethical attribution of credit and responsibilities in scholarly publications.
Relative depths of the subsurface peaks of phytoplankton abundance conserved over ocean provinces
Authors: Sato Mitsuhide , Shiozaki Takuhei , Hashihama Fuminori , Kodama Taketoshi , Ogawa Hiroshi , Saito Hiroaki , Tsuda Atsushi , Takeda Shigenobu , Furuya Ken 
Published: September 2022

AbstractFlow cytometric data collected from more than 250 stations in the Pacific and Indian Oceans were analyzed to determine the factors affecting the depth and magnitude of the subsurface abundance maximum of Synechococcus, Prochlorococcus, and small eukaryotes (< 6 μm). The peak depth of each phytoplankton population estimated by curve fitting was strongly correlated with the depth of the subsurface chlorophyll maximum (SCM). The slope of the regression line demonstrated that the peak depths of Synechococcus, Prochlorococcus, and small eukaryotes were 74% ± 1%, 88% ± 1%, and 104% ± 1% of the SCM depth (with confidence interval of 95%), respectively. This trend was largely conserved across the different ocean provinces of the Pacific and Indian Oceans. The peaks of Synechococcus frequently appeared in the nitrate‐depleted layer of subtropical waters, suggesting their high affinity for regenerated and/or organic nutrients. The estimated daily irradiance received at the peak depths of Synechococcus and Prochlorococcus did not show a distinct latitudinal trend and fluctuated among neighboring stations, whereas that of small eukaryotes slightly increased toward the subarctic region. The present results show that the peak depths of Synechococcus, Prochlorococcus, and small eukaryotes relative to SCM were globally conserved on average, which is largely in line with the difference in their ability to acquire light and nutrients. However, the absolute light level and nutrient concentrations at the peak depths varied dramatically among neighboring stations, likely affected by physical movements.
Stream metabolism sources a large fraction of carbon dioxide to the atmosphere in two hydrologically contrasting headwater streams
Authors: Bernal Susana , Cohen Mathew J. , Ledesma José L. J. , Kirk Lily , Martí Eugènia , Lupon Anna 
Published: September 2022

AbstractHeadwater streams are control points for carbon dioxide (CO2) emissions to the atmosphere, with relative contributions to CO2 emission fluxes from lateral groundwater inputs widely assumed to overwhelm those from in‐stream metabolic processes. We analyzed continuous measurements of stream dissolved CO2 and oxygen (O2) concentrations during spring and early summer in two Mediterranean headwater streams from which we evaluated the contribution of in‐stream net ecosystem production (NEP) to CO2 emission. The two streams exhibited contrasting hydrological regimes: one was non‐perennial with relatively small groundwater inflows, while the other was perennial and received significant lateral groundwater inputs. The non‐perennial stream exhibited strong inverse coupling between instantaneous and daily CO2 and O2 concentrations, and a strong correlation between aerobic ecosystem respiration (ER) and gross primary production (GPP) despite persistent negative NEP. At the perennial stream, the CO2–O2 relationship varied largely over time, ER and GPP were uncorrelated, and NEP, which was consistently negative, increased with increasing temperature. Mean NEP contribution to CO2 emission was 51% and 57% at the non‐perennial and perennial stream, respectively. Although these proportions varied with assumptions about metabolic stoichiometry and groundwater CO2 concentration, in‐stream CO2 production consistently and substantially contributed to total atmospheric CO2 flux in both streams. We conclude that in‐stream metabolism can be more important for driving C cycling in some headwater streams than previously assumed.