bluuebunny/crossref_metadata_2025_split huggingface dataset:
DJ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons
Authors: Mazza Melissa Conti , Shuck Sarah C. , Lin Jiusheng , Moxley Michael A. , Termini John , Cookson Mark R. , Wilson Mark A. 
Published: June 2022

AbstractHuman DJ‐1 is a cytoprotective protein whose absence causes Parkinson's disease and is also associated with other diseases. DJ‐1 has an established role as a redox‐regulated protein that defends against oxidative stress and mitochondrial dysfunction. Multiple studies have suggested that DJ‐1 is also a protein/nucleic acid deglycase that plays a key role in the repair of glycation damage caused by methylglyoxal (MG), a reactive α‐keto aldehyde formed by central metabolism. Contradictory reports suggest that DJ‐1 is a glyoxalase but not a deglycase and does not play a major role in glycation defense. Resolving this issue is important for understanding how DJ‐1 protects cells against insults that can cause disease. We find that DJ‐1 reduces levels of reversible adducts of MG with guanine and cysteine in vitro. The steady‐state kinetics of DJ‐1 acting on reversible hemithioacetal substrates are fitted adequately with a computational kinetic model that requires only a DJ‐1 glyoxalase activity, supporting the conclusion that deglycation is an apparent rather than a true activity of DJ‐1. Sensitive and quantitative isotope‐dilution mass spectrometry shows that DJ‐1 modestly reduces the levels of some irreversible guanine and lysine glycation products in primary and cultured neuronal cell lines and whole mouse brain, consistent with a small but measurable effect on total neuronal glycation burden. However, DJ‐1 does not improve cultured cell viability in exogenous MG. In total, our results suggest that DJ‐1 is not a deglycase and has only a minor role in protecting neurons against methylglyoxal toxicity.image
Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split‐face, blinded, placebo‐controlled study
Authors: Shawahna Ramzi 
Published: June 2022

AbstractBackgroundWorldwide, grapes (Vitis vinifera L.; family: Vitaceae) are one of the most important fruits. Grapeseed oil is rich in bioactive constituents that could be beneficial to the health and aesthetic features of human skin.ObjectiveThis study was conducted to evaluate the effects of a novel grapeseed oil‐loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin.MethodsThis was a split‐face, blinded, placebo‐controlled study. A novel grapeseed oil‐loaded dermocosmetic nanoemulgel was developed, and its effects on the biophysical parameters of the facial skin were evaluated and compared to those of a placebo formulation on the cheeks of 15 healthy volunteers. Melanin, erythema, sebum production, fine and large facial pores, moisture, and elasticity levels were measured using Mexameter®, Corneometer®, Sebumeter®, Cutometer®, and VisioFace®. Measurements were made on weekly basis for 12 weeks.ResultsCompared to the placebo, the novel grapeseed oil‐loaded dermocosmetic nanoemulgel received significantly higher sensory scores with regard to appearance, color, odor, consistency, adhesion, sensation, cohesiveness, and spreadability (p‐value < 0.05). Additionally, the novel nanoemulgel continuously and significantly reduced skin melanin, erythema, sebum production, and fine and large pores (p‐value < 0.05). On the contrary, the novel nanoemulgel continuously and significantly increased skin moisture contents and elasticity (p‐value < 0.05).ConclusionThe novel grapeseed oil‐loaded dermocosmetic nanoemulgel had attractive cosmetic attributes that could be useful for improving imperfections of the human skin. Future studies are still needed to test and evaluate the benefits of this novel grapeseed oil‐loaded dermocosmetic nanoemulgel in disease conditions.
Exploratory study of fathers providing Kangaroo Care in a Neonatal Intensive Care Unit
Authors: Dong Qiuxia , Steen Mary , Wepa Dianne , Eden Amye 
Published: June 2022

AbstractAim and ObjectivesTo explore fathers' views and experiences of providing Kangaroo Care (KC) to their baby cared for in a Neonatal Intensive Care Unit (NICU).BackgroundKangaroo Care has been known to improve the health outcome for preterm, low birth weight and medically vulnerable term infants and achieve the optimal perinatal health wellbeing for parents and infants. Historically, mothers are considered as the dominant KC providers, whereas fathers are spectators and have been overlooked. Little is known about the fathers' perspectives in providing KC in NICUs.MethodsIndividual semi‐structured interviews were conducted with 10 fathers who delivered KC to their baby when in the NICU. Data were analysed using Braun and Clarke's six‐phase thematical framework. The Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist was followed to report this qualitative study.FindingsFathers in this study identified they were passing a silent language of love and connecting with their baby by the act of KC in a challenging environment. Three themes emerged: ‘Positive psychological connection’, ‘Embracing father‐infant Kangaroo Care’ and ‘Challenges to father‐infant Kangaroo Care’.ConclusionThe findings of this study show KC enhances the bonding and attachment between fathers and infants. The conceptualisation of the paternal role in caregiving to a newborn is evolving as a contemporary practice. Further research is warranted to confirm or refute the study findings. Policies and facilities should be modified to include father–infant KC within the fields of neonatal care.Relevance to Clinical PracticeIt is important for nurses and other health professionals to support and enable fathers to give KC. Father–infant KC is recommended in neonatal care settings
Professional Identity Threats in Interprofessional Collaborations: A Case of Architects in Professional Service Firms
Authors: Ahuja Sumati 
Published: June 2022

AbstractIncreased use of multidisciplinary teams to carry out tasks that were previously seen as the domain of one profession has brought the manner in which professions collaborate to the fore of management interests. Drawing on 49 in‐depth interviews with senior architects in four multidisciplinary professional service firms (PSFs), this article contributes to better understandings of identity threats in interprofessional collaborations. My findings bring to the fore two threats to architects' identity relating to fragmentation of work and competing professional values. I show how architects manage these threats through the simultaneous use of two responses: highlighting identity distinctions and modifying identity and practices. However, despite these strategies to defend against identity threats, respondents presented themselves as under‐recognized and often under‐compensated. These findings suggest that the strength of professional identity may not merely mediate threats to professionals' identity but also be constraining by locking professionals in a kind of futile resistance and disrupting identity transformation. Further, responses to professional identity threats may result in a persistent identity struggle that renders professionals vulnerable to deep insecurities regarding their worth in interprofessional collaborations. The article contributes to recent debates on the unintended consequences of interprofessional collaborations thus highlighting the challenges of finding better ways to work together.
“You gotta give them hope”: A structural psychobiography of Harvey Milk (1930–1978)
Authors: Weststrate Nic M. , McLean Kate C. 
Published: June 2022

AbstractObjectiveIn this psychobiographical study, we examined the life and times of social change agent Harvey Milk, one of the first openly gay public officials in the United States. Milk is remembered as a gay hero who fought for the rights of marginalized people, often by invoking the importance of hope. Milk was assassinated less than 1 year after his election.MethodWe adopt a structural psychobiographical approach, foregrounding social, cultural, political, and historical forces that intersect with personal factors to explain Milk's ascension to the status of social change agent.ResultsThis psychobiography tells the story of a man not destined to become a social change agent but who became one anyway because of shifting tides in the political climate of San Francisco in the 1970s, because of a series of catalytic events that started him down this path, because of a history of persecution as a gay Jew, and because of his enduring need for a stage upon which he could express his generative concern.ConclusionsOur analysis raises questions about the story that “belongs” to the agent of social change, and the story that “belongs” to the rest of us, as we remember him.
Decolonizing school psychology research: A systematic literature review
Authors: Grant Stephanie , Leverett Patrice , D'Costa Stephanie , Amie Kandyce Anderson , Campbell Stephanie McCullough , Wing Sydney 
Published: June 2022

AbstractSchool Psychologists are called to increase the well‐being of clients they serve. However, despite a focus on supporting academic and behavioral success, school psychology has been used to enforce Eurocentric standards of normalcy and behavior on students in schools, punishing and excluding those deemed different. “Othering” is rooted in a legacy of educational indoctrination and assimilation negatively impacting students from minoritized backgrounds and represents a “colonial present”. To evaluate the epistemic violence endemic to school psychology, we conducted a systematic literature review of the most recently published literature across five school psychology journals (n = 627) utilizing a decolonial framework. Articles were coded for demographic inclusion, empirical approach, disciplinary context, minoritized inclusion level, and acknowledgment of author situatedness and roles in maintaining colonialist structures. While, 81% of studies included some degree of minoritized inclusion, less than 5% of these articles utilized culturally responsive approaches or acknowledged colonialism or white supremacy. Recommendations for a movement toward a more decolonial approach to school psychology research are discussed.
Work–life balance in dreams: Frequency and emotional tone of work‐related and hobby‐related dreams
Authors: Schredl Michael , Coors Judith , Anderson Lilian Marie , Kahlert Lea Katharina , Kumpf Celine Sophie 
Published: June 2022

SummaryAs dreams reflect waking life, the so‐called continuity hypothesis of dreaming, the literature showing that work‐related stress affects dreams negatively is very plausible. As in waking life, hobbies are an important component in the work–life balance. In the present study, the work–life balance in dreams was studied. Overall, 1695 persons (960 women, 735 men; mean age: 53.84 ± 13.99 years) participated in an online survey entitled “Everyday life and dreams”. The data collected refer to the pre‐pandemic period. The findings indicate that hobby‐related dreams are more frequent in persons who often engage in their hobbies, supporting the notion of a thematic continuity. As expected, the emotional tone of hobby‐related dreams was more positive compared with dreams in general and work‐related dreams in particular. Interestingly, the emotional valence of hobby‐related dreams was related to the valence of general emotionality towards work in waking life, supporting the idea of an emotional continuity between waking and dreaming. The work–life balance in dreams could be defined as the difference of the percentages of work‐related and hobby‐related dreams; it is linked to work‐related stress and the hobby frequency, factors similar to those that shift the work–life balance in waking life toward the “work” end of the spectrum.
Transcriptome analyses profiles of dietary l‐alanyl‐l‐glutamine supplementation in Amur sturgeon, Acipenser schrenckii, liver
Authors: Wang Chang'an , Sun Xiao , Lu Shaoxia , Wang Liansheng , Li Jinnan , Fan Ze , Wu Di , Liu Yang , Zhang Yuanyuan , Jiang Haibo , Han Shicheng , Liu Hongbai 
Published: June 2022

AbstractTo investigate the effect of dietary l‐Alanyl‐l‐glutamine (Ala‐Gln) supplementation on Amur sturgeon, Acipenser schrenckii, 180 healthy fish (initial body weight 21.23 ± 0.17 g) were divided into two groups (30 fish per tank, each treatment in triplicate) and treated with 0.0% (control) and 1.0% Ala‐Gln for 56 days. The growth performance improved significantly with dietary Ala‐Gln supplementation. Transcriptome profiles of dietary Ala‐Gln supplementation in sturgeon were generated using second‐generation Illumina sequencing technology. A total of 2891 differentially expressed genes (DEGs) were obtained, including 901, which were upregulated, and 1990, which were downregulated, in the treatment group relative to the control group. These genes are mainly involved in the general function, regulation of replication, recombination and repair, signal transduction mechanisms, amino acids and lipid transport and metabolism, and other biological processes. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of DEGs showed that cytokine–cytokine receptor interaction, biosynthesis of unsaturated fatty acids, and beta‐alanine metabolism were the top three most significantly enriched pathways out of the 20 highly enriched pathways detected in A. schrenckii. The expression patterns of DEGs were validated by quantitative real‐time polymerase chain reaction. Our findings provide a comprehensive insight into A. schrenckii genes and pathways with altered expression following dietary Ala‐Gln supplementation.
Infant age at egg introduction and malnutrition‐related child growth in the United States
Authors: Mi Baibing , Liu Huimeng , Wang Yutong , Small Hannah , Surguy‐Bowers Ariana , Rideout Todd C. , Cameron Claire E. , Lehman Heather K. , Starke Krystal , Wen Xiaozhong 
Published: June 2022

AbstractTo evaluate the relationship between infant age of egg introduction and malnutrition‐related growth outcomes in the United States, we analysed secondary data of 1716 mother–child dyads in the Infant Feeding Practices Study II and its Year 6 Follow‐Up Study. Malnutrition‐related growth outcomes included body mass index z‐score (BMIZ), obesity (weight‐for‐height z‐score [WHZ] ≥3 or BMIZ ≥ 2), WHZ, wasting (WHZ < −2), height‐for‐age z‐score (HAZ), and stunting (HAZ < –2). Infant age at egg introduction was analysed as a continuous variable. We used generalised estimating equations to estimate the mean difference in continuous outcomes and relative risk [RR]) for binary outcomes, adjusting for related maternal and child confounders. We also explored interactions with child sex, maternal race/ethnicity, maternal educational level, ever breastfeeding, and formula feeding. In the total sample, a later infant age at egg introduction was associated with a lower mean difference in HAZ (confounder‐adjusted mean difference = −0.08, 95% confidence interval [CI]: −0.12 to −0.03 per month) and a higher risk of stunting (confounder‐adjusted RR = 1.17, 95% CI: 1.03–1.33 per month) at 6 years. The associations between infant age at egg introduction and 12‐month growth outcomes differed by child sex. Among females but not among males, later introduction of eggs was associated with a lower mean WHZ (−0.06 [−0.12 to 0.00] per month) at 12 months. Later egg introduction during infancy was associated with a lower mean HAZ and a higher risk of stunting in 6‐year‐old children. Besides this, it was associated with a lower WHZ among females at 12 months.
Metabarcoding analysis of marine zooplankton confirms the ecological role of a sheltered bight along an exposed continental shelf
Authors: Govender Ashrenee , Singh Sohana , Groeneveld Johan , Pillay Sureshnee , Willows‐Munro Sandi 
Published: June 2022

AbstractZooplankton plays an essential role in marine ecosystems as the link between primary producers (phytoplankton) and higher trophic levels in food webs, and as a dynamic pool of recruits for invertebrates and fish. Zooplankton communities are diverse with a patchy distribution at different spatial scales, influenced by oceanographic processes. The continental shelf of eastern South Africa is narrow and exposed to the western‐boundary Agulhas Current, with some shelter against strong directional flow provided by the broader KwaZulu‐Natal Bight, a coastal offset adjacent to an estuary. We compared zooplankton species richness, diversity and relative abundance of key taxa among sheltered and exposed shelf areas using metabarcoding and community analysis, to explore the ecological role of the bight in a highly dynamic ocean region. Metabarcoding recovered higher richness and diversity at a finer resolution than could previously be achieved with traditional microscopy. Of 271 operational taxonomic units (OTUs) recovered through metabarcoding, 63% could be matched with >95% sequence similarity to reference barcodes. OTUs were dominated by malacostracan crustaceans (161 spp.), ray‐finned fishes (45 spp.) and copepods (28 spp.). Species richness, diversity and the relative abundance of key taxa differed between sheltered and exposed shelf areas. Lower species richness in the bight was partly attributed to structurally homogeneous benthic habitats, and an associated reduction of meroplanktonic species originating from local benthic–pelagic exchange. High relative abundance of a ray‐finned fish in the bight, as observed based on fish eggs and read counts, confirmed that the bight is an important fish spawning area. Overall, zooplankton metabarcoding outputs were congruent with findings of previous ecological research using more traditional methods of observation.
Mechanisms of stress tolerance and their effects on the ecology and evolution of mycorrhizal fungi
Authors: Branco Sara , Schauster Annie , Liao Hui‐Ling , Ruytinx Joske 
Published: June 2022

SummaryStress is ubiquitous and disrupts homeostasis, leading to damage, decreased fitness, and even death. Like other organisms, mycorrhizal fungi evolved mechanisms for stress tolerance that allow them to persist or even thrive under environmental stress. Such mechanisms can also protect their obligate plant partners, contributing to their health and survival under hostile conditions. Here we review the effects of stress and mechanisms of stress response in mycorrhizal fungi. We cover molecular and cellular aspects of stress and how stress impacts individual fitness, physiology, growth, reproduction, and interactions with plant partners, along with how some fungi evolved to tolerate hostile environmental conditions. We also address how stress and stress tolerance can lead to adaptation and have cascading effects on population‐ and community‐level diversity. We argue that mycorrhizal fungal stress tolerance can strongly shape not only fungal and plant physiology, but also their ecology and evolution. We conclude by pointing out knowledge gaps and important future research directions required for both fully understanding stress tolerance in the mycorrhizal context and addressing ongoing environmental change.
Spef1/CLAMP binds microtubules and actin‐based structures and regulates cell migration and epithelia cell polarity
Authors: Tapia Rocio , Hecht Gail A. 
Published: June 2022

AbstractDuring migration, cells invade, repair, and create barriers leading to the formation of new cellular contacts in target tissues. Cell migration requires many proteins that collectively form the cytoskeleton. The main cytoskeletal elements are actin filaments, microtubules (MTs), and intermediate filaments. These structures work in concert with a large number of accessory proteins that contribute in a variety of ways to regulate filament assembly and turnover, to alter the configuration or arrangement of filaments by bundling or crosslinking, to link the cytoskeleton to other structures in the cell, such as membranes and junctions, and to transport cargo along the filaments. Sperm flagella protein‐1 (Spef1), also designated calponin homology and microtubules‐associated protein (CLAMP), is a multifunctional protein that interacts with cytoskeletal structures, including MTs, actin filaments, and focal adhesions in epithelia. In this review, we outline Spef1/CLAMP structure and expression in several cellular models. The function of Spef1/CLAMP in flagellar and ciliary motility, MT‐binding and stability, regulation of planar cell polarity, and potential contribution to the maintenance of actin‐based structures, such as lamellipodia and filopodia during cell migration, are also discussed.
Centre‐Based Care and Parenting Activities*
Authors: Jessen Jonas , Spieß Christa Katharina , Waights Sevrin 
Published: June 2022

AbstractWe examine the relationship between parenting activities and centre‐based care using time diary and survey data for mothers in Germany. While mothers using centre‐based care spend significantly less time in the presence of their child, we find that differences in the time spent on specific activities such as reading, talking, and playing with the child are relatively small or zero. The pattern of results is more pronounced for lower education mothers. The lack of large decreases in activities is explained by two factors: (i) that centre care replaces time that parents spend with the child but are doing other things such as housework or leisure (a small direct effect), and (ii) that evenings become relatively more activity‐rich (a compensating indirect effect). For the intensive margin (full‐day vs. half‐day), we find more additional reductions in parenting activities, but these are compensated for by lower education mothers during non‐centre hours. Our findings represent novel evidence that activities in the home environment are a complement to centre‐based care, highlighting a credible additional mechanism for child development effects of centre‐based care.