bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Aidi Injection Treating of Nonsmall Cell Lung Cancer
Authors: Zhang Weizhou , Peng Wenpan , Li Yehui , Pan Tingyu , Feng Fanchao , Xu Jie , Zhou Xianmei 
Published: December 2022

Background. Aidi injection (ADI) is a compound preparation injection of Chinese herbs used to treat patients of nonsmall cell lung cancer (NSCLC) in China. This study aimed to reveal the mechanism of ADI in the treatment of NSCLC by using network pharmacology and molecular docking. Methods. The related targets of ADI and NSCLC were obtained from multiple databases. The network diagram of disease-drug-components-targets (DDCT) and protein-protein interaction (PPI) was constructed to screen key targets. Then, the key targets and main signaling pathways were screened by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Next, in order to validate the results of network pharmacology, expression analysis and survival analysis of key genes were performed. Finally, we carried out the technology of molecular docking to further validate the accuracy of the above results. Results. A total of 207 targets of ADI and 5282 targets of NSCLC were obtained finally. Through the construction of DDCT and PPI network diagrams, 28 key targets were finally obtained. The results of the KEGG enrichment analysis indicated that multiple signaling pathways were associated with NSCLC, which included the MAPK signaling pathway, the IL-17 signaling pathway, and the PI3K/AKT signaling pathway. The key genes in the signaling pathway mainly include TP53, CASP3, MMP9, AKT1, PTGS2, and MAPK1. The results of differently expressed analysis of key genes showed that TP53, CASP3, MMP9, AKT1, PTGS2, and MAPK1 had statistical differences in lung squamous cell carcinoma (LUSC) compared with normal tissue

p
<
0.001

. In lung adenocarcinoma (LUAD), the expression of TP53, CASP3, MMP9, AKT1, and PTGS2 had statistical differences compared with normal tissue

p
<
0.001

, while the expression of MAPK1 had no statistical difference

p
>
0.05

. The results of survival analysis of key genes showed that AKT1, MAPK1, CASP3, MMP9, TP53, and PTGS2 had statistical differences in the OS or RFS of NSCLC patients

p
<
0.05

. In addition, the results of molecular docking indicated that the key genes and the main components have good docking activity. Conclusions. This study revealed the potential mechanism of ADI in the treatment of NSCLC with multipathways and multitargets and provided a scientific basis for the in-depth study of ADI in the treatment of NSCLC.
Cost-Effectiveness of Endovascular Treatment in Large Vessel Occlusion Stroke With Mild Prestroke Disability: Results From the HERMES Collaboration
Authors: Ospel Johanna M. , Kunz Wolfgang G. , McDonough Rosalie V. , van Zwam Wim , Pinckaers Floor , Saver Jeffrey L. , Hill Michael D. , Demchuk Andrew M. , Jovin Tudor G. , Mitchell Peter , Campbell Bruce C.V. , White Phil , Muir Keith , Achit Hamza , Bracard Serge , Brown Scott , Goyal Mayank ,   for the HERMES Investigators
Published: December 2022

Background:
The clinical and economic benefit of endovascular treatment (EVT) in addition to best medical management in patients with stroke with mild preexisting symptoms/disability is not well studied. We aimed to investigate cost-effectiveness of EVT in patients with large vessel occlusion and mild prestroke symptoms/disability, defined as a modified Rankin Scale score of 1 or 2.

Methods:
Data are from the HERMES collaboration (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials), which pooled patient-level data from 7 large, randomized EVT trials. We used a decision model consisting of a short-run model to analyze costs and functional outcomes within 90 days after the index stroke and a long-run Markov state transition model (cycle length of 12 months) to estimate expected lifetime costs and outcomes from a health care and a societal perspective. Incremental cost-effectiveness ratio and net monetary benefits were calculated, and a probabilistic sensitivity analysis was performed.

Results:
EVT in addition to best medical management resulted in lifetime cost savings of $2821 (health care perspective) or $5378 (societal perspective) and an increment of 1.27 quality-adjusted life years compared with best medical management alone, indicating dominance of additional EVT as a treatment strategy. The net monetary benefits were higher for EVT in addition to best medical management compared with best medical management alone both at the higher (100 000$/quality-adjusted life years) and lower (50 000$/quality-adjusted life years) willingness to pay thresholds. Probabilistic sensitivity analysis showed decreased costs and an increase in quality-adjusted life years for additional EVT compared with best medical management only.

Conclusions:
From a health-economic standpoint, EVT in addition to best medical management should be the preferred strategy in patients with acute ischemic stroke with large vessel occlusion and mild prestroke symptoms/disability.
A Survey on Cross-Lingual Summarization
Authors: Wang Jiaan , Meng Fandong , Zheng Duo , Liang Yunlong , Li Zhixu , Qu Jianfeng , Zhou Jie 
Published: December 2022

Abstract
Cross-lingual summarization is the task of generating a summary in one language (e.g., English) for the given document(s) in a different language (e.g., Chinese). Under the globalization background, this task has attracted increasing attention of the computational linguistics community. Nevertheless, there still remains a lack of comprehensive review for this task. Therefore, we present the first systematic critical review on the datasets, approaches, and challenges in this field. Specifically, we carefully organize existing datasets and approaches according to different construction methods and solution paradigms, respectively. For each type of dataset or approach, we thoroughly introduce and summarize previous efforts and further compare them with each other to provide deeper analyses. In the end, we also discuss promising directions and offer our thoughts to facilitate future research. This survey is for both beginners and experts in cross-lingual summarization, and we hope it will serve as a starting point as well as a source of new ideas for researchers and engineers interested in this area.
An End-to-End Contrastive Self-Supervised Learning Framework for Language Understanding
Authors: Fang Hongchao , Xie Pengtao 
Published: December 2022

Abstract
Self-supervised learning (SSL) methods such as Word2vec, BERT, and GPT have shown great effectiveness in language understanding. Contrastive learning, as a recent SSL approach, has attracted increasing attention in NLP. Contrastive learning learns data representations by predicting whether two augmented data instances are generated from the same original data example. Previous contrastive learning methods perform data augmentation and contrastive learning separately. As a result, the augmented data may not be optimal for contrastive learning. To address this problem, we propose a four-level optimization framework that performs data augmentation and contrastive learning end-to-end, to enable the augmented data to be tailored to the contrastive learning task. This framework consists of four learning stages, including training machine translation models for sentence augmentation, pretraining a text encoder using contrastive learning, finetuning a text classification model, and updating weights of translation data by minimizing the validation loss of the classification model, which are performed in a unified way. Experiments on datasets in the GLUE benchmark (Wang et al., 2018a) and on datasets used in Gururangan et al. (2020) demonstrate the effectiveness of our method.
Empedocles the Wandering Daimōn and Trusting in Mad Strife
Authors: Tor Shaul 
Published: December 2022

Abstract
This article argues that Empedocles’ trust in Strife (DK31 B115.14 = LM22 D10.14) is not, as the prevailing interpretation has it, only a past misjudgement and failure. Rather, trust in Strife still, and to his own lament, infects Empedocles’ mind and informs his life. This detail then offers a fresh perspective on Empedocles’ self-conception and on how, through the daimōn’s cosmic peregrinations, Empedocles raises and pursues questions of agency and responsibility. Furthermore, it sheds light on Empedocles’ understanding of his own ethical standing: common assumptions to the contrary notwithstanding, he does not see himself as an unqualifiedly successful embodiment of his own ideals.
Affective Citizenship in Brexit Britain: EU Citizens’ Responses to Emotional Governance
Authors: Barrios Aquino Marianela 
Published: December 2022

Abstract
Brexit has exacerbated the importance of understanding the affective dimension of citizenship for EU citizens residing in the southeast of England after the UK’s 2016 referendum on membership of the EU. The state’s emotional governance, manifested in citizenship policies and the naturalisation process, reveals a complex understanding of belonging and exclusion in the context of intra-EU mobility. In this essay I focus on how naturalisation requirements establish the emotions that new citizens should feel and the impact this has on their representation of citizenship. This analysis focuses on three out of thirty-four semi-structured interviews conducted in 2017 with EU citizens at different stages of the naturalisation process. Findings show that the political context emphasises the emotional elements of naturalisation in a context of political instability. I conclude that participants’ accounts reveal their resistance to the way the state attempts to govern through emotions. This resistance serves as an indicator of emotional governance in Brexit Britain.
A Hierarchical Dissection of Multiscale Forcing on the Springtime Mesoscale Convective Systems in the United States
Authors: You Zhenyu , Deng Yi 
Published: December 2022

Abstract
Mesoscale convective systems (MCSs) play a key role in regulating variability in the U.S. water and energy cycle. Here a hierarchical dissection of the multiscale forcing of springtime MCSs is carried out through a two-step classification process. Hierarchical clustering is first applied to spatiotemporally evolving upper-tropospheric height fields to reveal large-scale forcing patterns of MCSs. Five distinct forcing patterns (clusters) are identified with three being “remotely forced” and two associated with “local growth.” The upper-level troughs associated with these forcing patterns create broad envelopes downstream within which large-scale ascent and MCS genesis tend to occur. Further classification of MCSs based on MCS track locations reveals that local dynamic and thermodynamic forcing determines the precise locations of MCS genesis in the envelope created by large-scale forcing. Specifically, MCSs often occur near surface fronts in warm sectors of surface low pressure systems and are accompanied by low-level kinematic and moisture convergence driven by low-level jets (LLJs). Nearly 50% of spring MCSs are associated with potential instability realized through frontal lifting, and the highest probability of MCS genesis is seen with an environmental CAPE of ∼1400 J kg−1 and CIN of ∼150 J kg−1. The positive trend of the U.S. MCS genesis frequency observed in recent decades is found to be driven by the cluster of MCSs forced at large scale by the Pacific storm track. Regression analysis further suggests that the growing phase of the Pacific decadal oscillation (PDO) modulates the associated MCS large-scale forcing and is ultimately responsible for the positive MCS trend.

Significance Statement
The purpose of this study is to provide a systematic classification of multiscale forcing factors triggering mesoscale convective system development over the United States. These storms are very active in spring and often lead to intense rainfall and other weather hazards such as lightning, hail, and tornadoes. They play a key role in the U.S. hydrological cycle and have been occurring more frequently over the past several decades. Our study reveals the detailed characteristics of atmospheric forcing leading to these storms. Such information lays theoretical grounds for designing prediction schemes of warm season severe weather and provides guidance for model development to improve climate models’ simulation and long-term projection of these storms.
Sensitivity of MPI-ESM Sea Level Projections to Its Ocean Spatial Resolution
Authors: Wickramage Chathurika , Köhl Armin , Jungclaus Johann , Stammer Detlef 
Published: December 2022

Abstract
The dependence of future regional sea level changes on ocean model resolution is investigated based on Max Planck Institute Earth System Model (MPI-ESM) simulations with varying spatial resolution, ranging from low resolution (LR), high resolution (HR), to eddy-rich (ER) resolution. Each run was driven by the shared socioeconomic pathway (SSP) 5-8.5 (fossil-fueled development) forcing. For each run the dynamic sea level (DSL) changes are evaluated by comparing the time mean of the SSP5-8.5 climate change scenario for the years 2080–99 to the time mean of the historical simulation for the years 1995–2014. Respective results indicate that each run reproduces previously identified large-scale DSL change patterns. However, substantial sensitivity of the projected DSL changes can be found on a regional to local scale with respect to model resolution. In comparison to models with parameterized eddies (HR and LR), enhanced sea level changes are found in the North Atlantic subtropical region, the Kuroshio region, and the Arctic Ocean in the model version capturing mesoscale processes (ER). Smaller yet still significant sea level changes can be found in the Southern Ocean and the North Atlantic subpolar region. These sea level changes are associated with changes in the regional circulation. Our study suggests that low-resolution sea level projections should be interpreted with care in regions where major differences are revealed here, particularly in eddy active regions such as the Kuroshio, Antarctic Circumpolar Current, Gulf Stream, and East Australian Current.

Significance Statement
Sea level change is expected to be more realistic when mesoscale processes are explicitly resolved in climate models. However, century-long simulations with eddy-resolving models are computationally expensive. Therefore, current sea level projections are based on climate models in which ocean eddies are parameterized. The representation of sea level by these models considerably differs from actual observations, particularly in the eddy-rich regions such as the Southern Ocean and the western boundary currents, implying erroneous ocean circulation that affects the sea level projections. Taking this into account, we review the sea level change pattern in a climate model with featuring an eddy-rich ocean model and compare the results to state-of-the-art coarser-resolution versions of the same model. We found substantial DSL differences in the global ocean between the different resolutions. Relatively small-scale ocean eddies can hence have profound large-scale effects on the projected sea level which may affect our understanding of future sea level change as well as the planning of future investments to adapt to climate change around the world.
A Long-Term Simulation of Land Surface Conditions at High Resolution over Continental China
Authors: Ji Peng , Yuan Xing , Shi Chunxiang , Jiang Lipeng , Wang Guoqing , Yang Kun 
Published: December 2022

Abstract
With the improvement of meteorological forcings and surface parameters, high-resolution land surface modeling is expected to provide locally relevant information. Yet, its added value over the state-of-the-art global reanalysis products requires long-term evaluations over large areas, given uneven climate warming and significant land cover change. Here, the Conjunctive Surface–Subsurface Process version 2 (CSSPv2) model, with a reasonable representation of runoff generation, subgrid soil moisture variability and urban dynamics, is calibrated and used to perform a 6-km resolution simulation over China during 1979–2017. Evaluations against observations at thousands of stations and several satellite-based products show that the CSSPv2 has 67%, 29%, and 15% lower simulation errors for snow depth, evapotranspiration (ET), and surface and root-zone soil moisture, respectively, than nine global products. The median Kling–Gupta efficiency of the streamflow for 83 river basins is 0.66 after bulk calibrations, which is 0.38 higher than that of global datasets. The CSSPv2 also accurately simulates urban heat islands (UHIs) and the patterns and magnitudes of long-term snow depth, ET, and soil moisture trends. However, the global products do not detect UHIs and overestimate the trends (or show opposite trends) of snow depth and ET. Sensitivity experiments with coarse-resolution forcings and surface parameters reveal that advanced model physics and high-resolution surface parameters are vital for improved simulations of snow depth, ET, soil moisture, and UHIs, whereas high-resolution meteorological forcings are critical for modeling long-term trends. Our research emphasizes the substantial added value of long-term high-resolution land surface modeling to present global products at continental scales.

Significance Statement
Highly heterogeneous changes of terrestrial water and energy require kilometer-scale land surface information for the adaptation. High-resolution land surface modeling has been regarded as a promising approach to provide locally relevant information, but most applications are limited to a small region or a short period. By performing sets of 6-km resolution simulations over China during 1979–2017 with the Conjunctive Surface–Subsurface Process version 2 land model, here we show that high-resolution modeling has 15%–67% lower simulation errors of snow depth, streamflow, evapotranspiration, and soil moisture than nine global products, and the improvement is mainly attributed to the advances in model physical parameterizations and high-resolution surface parameters. Our results emphasize the great added value of kilometer-scale land surface modeling at continental scales.
Use of del Nido cardioplegia in acute coronary syndrome cases with decreased ejection fraction
Authors: Sanetra Krzysztof , Gerber Witold , Domaradzki Wojciech , Mazur Marta , Synak Magdalena , Kubaszewska Marta , Kaźmierczak Paweł , Buszman Piotr P , Bochenek Andrzej 
Published: December 2022

Background There has been increasing interest in using del Nido cardioplegia in adult cardiac surgery. However, there is limited evidence for its efficacy in patients with acute coronary syndrome and reduced ejection fraction. Methods This study examined patients with decreased ejection fraction (EF < 40%) who were hospitalized due to acute coronary syndrome and received either del Nido (DN) or cold blood cardioplegia (CB). The patients were matched based on age, gender, myocardial infarction at baseline, and number of conducted surgical procedures. An analysis was conducted on postoperative biomarker release (high-sensitivity troponin T and isoenzyme creatine kinase-MB (CK-MB)), changes in myocardial contractility and perioperative outcomes. Results 62 pairs of patients with similar baseline characteristics were selected. 51.6% of pairs underwent isolated coronary artery bypass grafting, while 48.4% underwent a complex procedure. Postoperative troponin values did not differ significantly at 12 h (median (IQR): 606.7 (381.4–974.8) pg/mL vs. 552 (231.8–1579.5) pg/mL; p = 0.913), nor did CK-MB (median (IQR): 24.3 (12.6–45.5) ng/mL vs. 23.7 (12.3–49.8) ng/mL; p = 0.972). The postoperative EF was similar between groups (median (IQR): 30% (30–35%) vs. 34% (30–38%); p = 0.323). No difference in perioperative mortality, myocardial infarction, stroke, or composite endpoint was noted. In a multivariate analysis, the cardioplegia protocol did not affect biomarker release or changes in ejection fraction. The first stage of acute kidney injury was more frequent in the CB group (28.5% vs. 9.7%, p = 0.033). Conclusions Both del Nido and cold blood cardioplegia provide adequate cardioprotection in patients with acute coronary syndrome with decreased ejection fraction.
Return to Sports After Closed Reduction of Acute Traumatic Posterior Sternoclavicular Joint Dislocations: A Systematic Review
Authors: Damschen Jordan , Nowak Matthew , Murphy Alexandria , Park Seungkyu , Li Xinning , Galvin Joseph 
Published: December 2022

Background: Acute traumatic posterior sternoclavicular (SC) joint dislocation is a serious injury given its potential to cause cardiovascular and airway compromise that typically will require emergent closed reduction. There are limited data on the rate of return to sports (RTS) after this injury pattern when treated in a closed fashion. Purpose: To systematically review the literature and evaluate (1) the rate of RTS after closed reduction of posterior SC dislocation and (2) the timeline for RTS after closed reduction of posterior SC dislocation. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review was performed using the PubMed, EBSCOhost, and Elsevier databases with the search term “sternoclavicular dislocation.” Inclusion criteria were publications reporting successful closed reduction of posterior SC joint dislocation and containing data relevant to the study objectives. Exclusion criteria were cases with unsuccessful closed reduction, open surgical reduction, concomitant fracture, epiphyseal disruption, superior or anterior dislocation, subluxation injury, treatment without reduction, and atraumatic or congenital origins. Results: Sixteen studies and an additional forthcoming case at the authors’ institution were identified to have documented RTS with a total of 31 patients. Of these patients, 23 (74%) in the cohort had full RTS. Eight of the 16 studies plus the additional case reported a timeline for RTS. The mean time to RTS was 3.1 months (range, 1-6 months). Of the 8 patients who did not return to preinjury sports or activity, 12.9% (4/31) reported restrictions with sports or activity, 6.5% (2/31) changed to a sport with less contact, 3.2% (1/31) experienced symptomatic recurrence requiring surgical stabilization, and 3.2% (1/31) quit the sport. Conclusion: Closed reduction of acute traumatic posterior SC joint dislocations provides high RTS rates with low rates of secondary surgical stabilization. The mean time to RTS at the preinjury activity level was 3.1 months.