bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Discursive Review of Recent Development and Patents on Glycerosomes
Authors: Singh Ragini , Zeeshan Fatima , Srivastava Dipti , Awasthi Himani 
Published: March 2022

Background:
To achieve a target-based drug delivery with minimal side effects, novel drug
delivery systems are being continuously explored. Vesicular systems are one such system that can
ameliorate the bioavailability of the encapsulated drug by delivering the drug at the targeted site and
can minimize the side effect.

Objective:
The objective of this review is to provide a vivid description of glycerosomes and their applications.
Glycerosomes are sphere-shaped versatile vesicles consisting of one or more phospholipid
bilayers similar to liposomes but contain a high concentration of glycerol, which modifies the liposome
bilayer fluidity. Glycerosomes can encapsulate both hydrophobic and hydrophilic drugs, which makes
them the promising vehicle in the field of drug delivery.

Conclusion:
Most of the glycerosome formulations prepared were targeted for topical delivery and in
particular, a cutaneous route where they have shown promising results. These vesicles are
biocompatible and due to the high glycerol concentration, they have improved spreadability and
penetrability. It is therefore imperative to explore the other topical routes such as ocular, vaginal, nasal,
and rectal for delivery of drugs.
Examining Anxiety Treatment Information Needs: Web-Based Survey Study
Authors: Bernstein Matthew T , Reynolds Kristin A , Jakobson Lorna S , Stoesz Brenda M , Alcolado Gillian M , Furer Patricia 
Published: March 2022

Background
Several treatments for anxiety are available, which can make treatment decisions difficult. Resources are often produced with limited knowledge of what information is of interest to consumers. This is a problem because there is limited understanding of what people want to know when considering help for anxiety.

Objective
This study aimed to examine the information needs and preferences concerning treatment options for anxiety by assessing the following: what information people consider to be important when they are considering treatment options for anxiety, what information people have received on psychological and medication treatment in the past, how they received this information in the past, and whether there are any differences in information needs between specific samples and demographic groups.

Methods
Using a web-based survey, we recruited participants from a peer-support association website (n=288) and clinic samples (psychology, n=113; psychiatry, n=64).

Results
Participants in all samples wanted information on a broad range of topics pertaining to anxiety treatment. However, they reported that they did not receive the desired amount of information. Participants in the clinic samples rated the importance of information topics higher than did those in the self-help sample. When considering the anxiety treatment information received in the past, most respondents indicated receiving information from informational websites, family doctors, and mental health practitioners. In terms of what respondents want to learn about, high ratings of importance were given to topics concerning treatment effectiveness, how it works, advantages and disadvantages, what happens when it stops, and common side effects.

Conclusions
It is challenging for individuals to obtain anxiety-related information on the range of topics they desire through currently available information sources. It is also difficult to provide comprehensive information during typical clinical visits. Providing evidence-based information on the web and in a brochure format may help consumers make informed choices and support the advice provided by health professionals.
Acceptability and Feasibility of a Return-to-Work Intervention for Posttreatment Breast Cancer Survivors: Protocol for a Co-design and Development Study
Authors: Bilodeau Karine , Gouin Marie-Michelle , Lecours Alexandra , Lederer Valérie , Durand Marie-José , Kilpatrick Kelley , Lepage David , Ladouceur-Deslauriers Lauriane , Dorta Tomas 
Published: March 2022

Background
The mortality rate from breast cancer has been declining for many years, and the population size of working-age survivors is steadily increasing. However, the recurrent side effects of cancer and its treatment can result in multiple disabilities and disruptions to day-to-day life, including work disruptions. Despite the existing knowledge of best practices regarding return to work (RTW) for breast cancer survivors, only a few interdisciplinary interventions have been developed to address the individualized needs and multiple challenges of breast cancer survivors, health care professionals, and employer and insurer representatives. Thus, it seems appropriate to develop RTW interventions collaboratively by using a co-design approach with these specific stakeholders.

Objective
This paper presents a protocol for developing and testing an innovative, interdisciplinary pilot intervention based on a co-design approach to better support RTW and job retention after breast cancer treatment.

Methods
First, a participatory research approach will be used to develop the intervention in a co-design workshop with 12 to 20 participants, including people affected by cancer, employer and insurer representatives, and health care professionals. Next, a pilot intervention will be tested in a primary care setting with 6 to 8 women affected by breast cancer. The acceptability and feasibility of the pilot intervention will be pretested through semistructured interviews with participants, health care professionals, and involved patient partners. The transcribed data will undergo an iterative content analysis.

Results
The first phase of the project—the co-design workshop—was completed in June 2021. The pilot test of the intervention will begin in spring 2022. The results from the test will be available in late 2022.

Conclusions
The project will offer novel data regarding the use of the co-design approach for the development of innovative, co-designed interventions. In addition, it will be possible to document the acceptability and feasibility of the pilot intervention with a primary care team. Depending on the results obtained, the intervention could be implemented on a larger scale.

International Registered Report Identifier (IRRID)
DERR1-10.2196/37009
UN LLAMADO NEOTROPICAL: REPOSITORIOS ACÚSTICOS DE LA HERPETOLOGÍA LATINOAMERICANA
Authors: Mendoza-Henao Angela , Ordoñez-Flores Samantha , Dena Simone , Toledo Luis Felipe , Guayasamín Juan M. , Franco Mena Daniela , Acevedo-Charry Orlando 
Published: March 2022

En las últimas décadas, el desarrollo de nuevas técnicas de muestreo nos ha permitido recolectar con mayor facilidad novedosas muestras que enriquecen el conocimiento de los especímenes que estudiamos. En este sentido, las muestras audiovisuales, sobre todo las grabaciones de señales acústicas, se han convertido en parte esencial de la investigación herpetológica. El correcto almacenamiento de estos especímenes es clave para fortalecer la investigación científica. Sin embargo, la gran mayoría de repositorios audiovisuales de acceso público se encuentran en países del Norte Global, lo cual restringe la labor científica en países latinos. El uso de repositorios locales o regionales abre la posibilidad de almacenar la diversidad de muestras científicas generadas en la región, haciéndolas fácilmente accesibles a los investigadores regionales y a la divulgación de la ciencia local. Esta carta es un llamado urgente a la comunidad herpetológica en Latinoamérica para que se tomen tres acciones principales como comunidad para aumentar la accesibilidad, reproducibilidad y crecimiento de la investigación bioacústica de anfibios neotropicales: 1) los investigadores deben depositar las grabaciones usadas en investigaciones publicadas en repositorios acústicos nacionales o regionales, 2) las editoriales y revisores de documentos deben exigir a los autores los números de depósito de todos los archivos utilizados en cualquier investigación acústica y la correcta referenciación de las colecciones usadas para poder aceptar los manuscritos y, 3) las directivas de las instituciones regionales con repositorios deben garantizar el fortalecimiento y mantenimiento de los repositorios acústicos institucionales por parte de las directivas de instituciones regionales.
Comparing patient-centered outcomes and efficiency of space closure between nickel-titanium closed-coil springs and elastomeric power chains during orthodontic treatment:
Authors: Badran Serene A. , Al-Zaben Juman M. , Al-Taie Lina M. , Tbeishi Haya , AL-Omiri Mahmoud K. 
Published: March 2022

ABSTRACTObjectivesTo compare patient-reported pain, discomfort, and difficulty in maintaining proper brushing between nickel-titanium closed-coil springs (CS) and elastomeric power chains (PC) when used for space closure. The secondary aims were to compare plaque control and efficiency of space closure between these two force delivery systems.Materials and MethodsA total of 48 patients who required extractions of upper first premolars and distal movement of upper canines had the CS randomly allocated to either the right or left side. Blinding was applied at data collection and analysis. Primary outcomes were pain intensity measured on visual analog scale, pain onset and duration, discomfort, and difficulty in maintaining proper brushing from the start of canine retraction at baseline and at 6 and 12 weeks thereafter. Secondary outcomes were plaque scores and the rate of space closure.ResultsNo significant differences in mean pain scores, pain onset, and duration at different time intervals between CS and PC were observed. The CS side was significantly less comfortable than the PC (P &lt; .0001) and more difficult to keep clean (P = .008). No significant differences in plaque scores were observed between CS and PC groups at any time interval. CS produced a faster rate of space closure than did PC (P = .008).ConclusionsCS were less tolerated than PC by patients but produced an average of 0.5 mm more movement than did the PC during the 12-week study period.
Effects of copper bioaccumulation on growth and biochemical constituents of the seedlings of Casuarina equisetifolia L.
Authors: Kumari B. M. Rathna 
Published: March 2022

Accumulation of heavy metals in the soil causes a significant impact on the biological processes in the plants. In the present study, the impact of bioaccumulation of copper (Cu) on the growth and biochemical constituents of the seedlings of Casuarina equisetifolia was assessed. The results showed that C. equisetifolia is a hyper-accumulator of Cu. The roots of the C. Equisetifolia significantly accumulated (p< 0.05) greater levels of Cu than stem and leaves. Similarly, the seedlings exposed to different concentrations of Cu showed differential height and collar diameter. The higher concentrations of Cu significantly (p< 0.05) hindered the fresh and dry weights of seedlings. It was noticed that accumulated Cu caused a significant decrease in levels of total carbohydrates, proteins and chlorophyll contents in C. equisetifolia seedlings.
Coagulopathy in severe acute pancreatitis: pathogenesis and potential correction methods
Authors: Андреенков В.С. 
Published: March 2022

Одной из актуальных проблем в лечении острого панкреатита является коагулопатия как приводящая к тромбоэмболическим осложнениям, так и переходящая в ДВС-синдром. В данной статье обобщено современное представление о патогенезе коагулопатии при остром панкреатите. В результате системной воспалительной реакции развивается комплексное нарушение свертывающей системы крови, выражающееся в изменении числа и функции тромбоцитов, гиперкоагуляции и вторичном гиперфибринолизе. Противосвертывающая система оказывается недостаточно эффективной в противодействии гиперкоагуляции. Компоненты свертывающей и противосвертывающей систем крови рассмотрены в статье в качестве терапевтической мишени в лечении коагулопатии при тяжелом остром панкреатите.
One of the actual problems in acute pancreatitis treatment is blood coagulation disorders, leading to both thromboembolic complications and disseminated intravascular coagulation. This article summarizes the current concepts of blood coagulation disorders in acute pancreatitis. Systemic inflammation response leads to complex blood coagulation disorder representingin thrombocyte count and function change, hypercoagulation, and secondary hyperfibrinolysis. Anticoagulation system is not effective in hypercoagulation prevention in these settings. Components of both coagulation and anticoagulation systems are considered as therapeutic targets of blood coagulation disorders treatment in acute pancreatitis.
Factor XII (Hageman) deficiency in obstetric practice: analysis of two cases
Authors: Работинский С.Е. , Буланова Е.Л. , Осокин И.П. , Сизова И.Ю. , Дзюба С.В. 
Published: March 2022

Наследственный дефицит фактора XII (синдром Хагемана) — генетически обусловленное заболевание, характеризующееся снижением активности фактора XII свертывания крови. Заболевание редкое (около 1 на 1 млн населения), наследуется преимущественно аутосомно-рецессивно, но в единичных тяжелых случаях выявляется аутосомно-доминантный тип наследования. Вопрос о необходимости профилактической заместительной терапии пациентам с наследственным дефицитом фактора XII при выполнении хирургических вмешательств остаётся открытым. В настоящей работе представлено 2 случая родоразрешения у пациенток с наследственным дефицитом фактора Хагемана без проведения заместительной терапии свежезамороженной плазмой, обсуждается роль этого фактора в гемостазе in vivo, использование интегральных тестов при данном состоянии.
Hereditary factor XII deficiency (Hageman trait) is a genetically determined disease characterized by a decrease in the activity of blood coagulation factor XII. The disease is rare (about 1 per 1 million of the population), inherited predominantly in an autosomal recessive manner, but in single severe cases, an autosomal dominant type of inheritance is revealed. The question of prophylactic replacement therapy in patients with hereditary factor XII deficiency during surgical interventions remains open. We present 2 delivery cases in patients with hereditary Hageman factor deficiency without replacement therapy with fresh frozen plasma, discuss the role of this factor in in vivo hemostasis, and the use of integral tests at this state.
Correlation of term usage and term indexing frequencies
Authors: Nelson Michael J. 
Published: March 2022

There have been several studies on the distributions of index terms, title terms, authors and other elements used in searching bibliographic databases. What is needed is to relate this information of the actual usage of terms in searching. This study uses data from monitoring the actual usage of terms in an online catalog at the School of Library and Information Science at the University of Western Ontario. Every time a term was used in a search expression, a count in the dictionary file was updated. If a word was not in the dictionary it was added. In this way we can see which words are in the catalog and not searched and also those which were searched but not in the dictionary. As a check on other studies the rank distribution of terms used in searching was checked and found to be of a general Zipf type.
The main interest was to check if high frequency terms in the catalog were used frequently in searching. Several measures of this were tried. First the regular scatterplot of frequency of use in the catalog versus the frequency in searching was checked and Pearson’s correlation coefficient was calculated. The correlation was reasonably high at 0.74. Since the total number of terms and frequencies was much larger in the catalog, a plot of the rank of the terms in the catalog was plotted against the rank of the term in searching.
This provided a very scattered plot with less clustering at the origin as in the original plot of frequencies. The Spearman rank correlation coefficient was moderate at 0.58. Some studies have suggested that removing high frequency and very low frequency terms from the search vocabulary will improve retrieval performance. This data shows that many general users actually use these terms in searching.
Currently a sample of search words are being analyzed for factors which affect the correlation, such as errors in both the catalog and searching, the effect of truncations, and the effect of stemming (which was done on both the catalog vocabulary and the search terms).
Fish-borne parasites proficient in zoonotic diseases: a mini review
Authors: Avishek Bardhan 
Published: March 2022

Fish-borne parasitic zoonoses are primarily found in people living in developing and underdeveloped countries. The parasites that cause such zoonoses like Trichinella and Taenia are well-known in developed nations, but few people are familiar with fish-borne parasitic zoonoses, which are largely caused by helminths and protozoans. In general, parasitic zoonoses transmitted by fish are rarely life-threatening, although cases and reports of such infestations have increased over the world. The list of parasitic organisms is extensive. This article attempts to provide a complete overview of the many fish-borne parasites that can cause zoonosis among humans and animals alike.
A Case of Dirty Dermatosis (Dermatitis Neglecta)
Authors: Henry Daniel , Henry David 
Published: March 2022

Dermatitis Neglecta, also known dermatosis neglecta refers to a dermatological condition that occurs from lack of hygiene. It is a condition that results from insufficient frictional cleansing leading to accumulation of corneocytes sebum and sweat eventually resulting in hyperpigmented patch or verrucous plaque. Regular bathing is very important for keeping the skin clean. Bathing and scrubbing the skin helps to remove germs, oils, and dead skin cells. Lack of bathing for a long time can also cause Dermatitis Neglecta. We are presenting a case of 22 years old boy who had itching in the scrotum for 4 years and he was being treated for scabies and tinea cruris by various practitioners. On observation we found it to be covered with dark coloured raised lesions, after we rubbed it with cotton and spirit, we found it to be Dermatitis Neglecta of scrotum. Terra firma forme dermatosis is differentiated from it by presence of sufficient hygiene, absence of corn flake-like brownish scales and successful annihilation of pigmentation with isopropyl alcohol in the former and effective clearance of lesions with soap and water in the latter. However, isopropyl alcohol is operative in both disorders.
Lintel decoration types from the Temple of Hatshepsut at Deir el-Bahari and their meaning
Authors: Madej Adrianna 
Published: March 2022

Examination of the set of preserved gate lintels from the Temple of Hatshepsut in Deir el-Bahari has revealed two models of the iconographic decoration: one that emphasizes pictorial content in the form of scenes of a cultic or symbolic nature, with inscriptions playing merely a complementary role, and the other based on the textual message alone. The use of a given model of lintel decoration appears to be a measure either of the function of the room or, more broadly, of the space, accessed through the gate, or of the context of the wall decoration around the entrance.
E EARNING MANAGEMENT: THE EFFECT OF MANAGEMENT OVERCONFIDENCE AND CORPORATE GOVERNANCE
Authors: Nanda Satria Tri , Zenita Raisya , Salimiah Neneng , Adino Intan 
Published: March 2022

Many studies have discussed the determinants of earning management. However, most of these studies discuss external factors of management such as audit quality and quality of disclosure and as a determinant of earning management. Study that tries to examine the intrinsic factors such as managerial overconfidence effect on earning management has not been widely conducted, especially in companies listed on IDX, Indonesia. This study aims to examine the effect of managerial overconfidence on earning management in companies listed on IDX. Furthermore, this study also aims to determine the moderating effect of corporate governance mechanisms on the relationship between managerial overconfidence. By using data analysis with the SEMPLS technique, the present study has succeeded to prove that managerial overconfidence affect earning management. Furthermore, this study also successfully provide evidence that corporate governance mechanisms such as independent audit committees and audit committee activities moderate the relationship between managerial overconfidence and earning management.
Media Audio Visual dalam Pembelajaran Pendidikan Agama Kristen: Studi Tentang Motivasi Belajar Siswa di Masa Pandemi
Authors: Massang Berdinata , Kindangen Meifa , Tulung Jeane Marie 
Published: March 2022

Penelitian ini dilatarbelakangi oleh rendahnya motivasi belajar siswa dalam pembelajaran PAK selama masa pandemi. Upaya yang dilakukan untuk meningkatkan motivasi belajar siswa adalah dengan penggunaan media audio visual dalam pembelajaran daring. untuk membantu pendidik dalam pelakasnaan pembelajaran PAK di sekolah selama masa pandemi atau wabah Covid-19. Penelitian ini merupakan penelitian kuantitatif komparatif dengan metode pre-eksperiment one group pre-test-posttest. Jumlah sampel yang digunakan dalam penelitian ini adalah 52 siswa kelas X SMA Negeri 4 Manado pada Tahun Ajaran 2020/2021 yang diambil secara acak. Teknik pengumpulan data dengan menggunakan instrumen angket yang dibagikan melalui google form. Teknik analisis data dengan menggunakan perbandingan rata-rata pengujian hipotesis. Hasil penelitian menunjukkan hasil post-test motivasi belajar siswa lebih tinggi dibanding hasil pre-test. Dari hasil tersebut maka kesimpulan dari penelitian ini adalah terdapat pengaruh dalam penggunaan media pembelajaran audio visual terhadap motivasi belajar siswa dalam pembelajaran PAK secara daring di kelas X SMA Negeri 4 Manado.
PENGARUH PAJAK DAERAH, LAIN-LAIN PENDAPATAN ASLI DAERAH YANG SAH, HASIL PENGELOLAAN KEKAYAAN DAERAH YANG DIPISAHKAN DAN RETRIBUSI DAERAH TERHADAP PENDAPATAN ASLI DAERAH KABUPATEN MAJALENGKA PERIODE 2017-2019
Authors: Sri Mulyani Hani , Ramdini Siska Ayu 
Published: March 2022

Permasalahan yang terjadi di Majalengka adalah tidak tercapainya PAD pada perubahan APBD 2019. Penelitian ini bertujuan untuk mengetahui Pengaruh Pajak Daerah, Lain-lain PAD yang Sah, Hasil Pengelolaan Kekayaan Daerah yang Dipisahkan dan Retribusi Daerah secara parsial dan simultan Terhadap PAD Kabupaten Majalengka Periode 2017-2019. Proksi yang digunakan adalah rasio kontribusi.
Penelitian ini merupakan penelitian kuantitatif dengan menggunakan data sekunder. Populasi dalam penelitian ini adalah Laporan Rekapitulasi Pendapatan Daerah Kabupaten Majalengka Periode 2017-2019. Sampel yang digunakan adalah Laporan Rekapitulasi Pendapatan Daerah Kabupaten Majalengka yang meliputi Pajak Daerah, Lain-lain PAD yang Sah, Hasil Pengelolaan Kekayaan Daerah yang Dipisahkan, Retribusi Daerah dan PAD selama 36 bulan periode 2017-2019. Teknik pengambilan sampel yang digunakan adalah sensus sampling. Alat analisis yang digunakan adalah Regresi Linier Berganda dan uji hipotesis melalui program SPSS versi 21.
Hasil penelitian menunjukkan bahwa Pajak Daerah berpengaruh signifikan dan positif terhadap PAD, Lain-lain PAD yang Sah tidak berpengaruh signifikan dan positif terhadap PAD, Hasil Pengelolaan Kekayaan Daerah yang Dipisahkan tidak berpengaruh signifikan dan positif terhadap PAD, Retribusi Daerah berpengaruh signifikan dan negatif terhadap PAD, dan Pajak Daerah, Lain-lain PAD yang Sah, Hasil Pengelolaan Kekayaan Daerah yang Dipisahkan dan Retribusi Daerah berpengaruh signifikan Terhadap PAD Kabupaten Majalengka Periode 2017-2019.