bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ontogenetic Transitions, Biomechanical Trade-Offs and Macroevolution of Scyphozoan Medusae Swimming Patterns
Authors: von Montfort Guilherme M. , Costello John H. , Colin Sean P. , Morandini André C. , Migotto Alvaro E. , Maronna Maximiliano , Reginato Marcelo , Miyake Hiroshi , Nagata Renato M. 
Published: November 2022

Abstract
Ephyrae, the early stages of scyphozoan jellyfish, possess a conserved morphology among species. However, ontogenetic transitions lead to morphologically different shapes among scyphozoan lineages, with important consequences for swimming biomechanics, bioenergetics and ecology. We used high-speed imaging to analyse biomechanical and kinematic variables of swimming in 17 species of Scyphozoa (1 Coronatae, 8 “Semaeostomeae” and 8 Rhizostomeae) at different developmental stages. Swimming kinematics of early ephyrae were similar, in general, but differences related to major lineages emerged through development. Rhizostomeae medusae have more prolate bells, shorter pulse cycles and higher swimming performances. Medusae of “Semaeostomeae”, in turn, have more variable bell shapes and most species had lower swimming performances. Despite these differences, both groups travelled the same distance per pulse suggesting that each pulse is hydrodynamically similar. Therefore, higher swimming velocities are achieved in species with higher pulsation frequencies. Our results suggest that medusae of Rhizostomeae and “Semaeostomeae” have evolved bell kinematics with different optimized traits, rhizostomes optimize rapid fluid processing, through faster pulsations, while “semaeostomes” optimize swimming efficiency, through longer interpulse intervals that enhance mechanisms of passive energy recapture.
A simple scoring system for the prediction of early pregnancy loss developed by following 13,977 infertile patients after in vitro fertilization
Authors: Ouyang Yan , Zhang Senmao , Peng Yangqin , Gong Fei , Li Xihong 
Published: November 2022

Abstract
In order to investigate a convenient simple scoring system for the prediction of early pregnancy loss (EPL) based on simple demographics, a retrospective study with 13,977 women undergoing transvaginal ultrasound scan on Days 27–29 after in vitro fertilization-embryo transfer (IVF-ET) from June 2016 and December 2017 was conducted. The first trimester pregnancy outcome was noted at 12 weeks of gestation. The areas under the curve of this scoring system were 0.884 (95% confidence interval (CI) 0.870-0.899) and 0.890 (95% CI 0.878-0.903) in the training set and test set, respectively. The score totals ranged from point -8 to 14. Points 5 which offered the highest predictive accuracy (94.01%) and corresponded to a 30% miscarriage risk, was chosen as the cutoff value, with a sensitivity of 62.84%, specificity of 98.79%, positive predictive value (PPV) of 88.87% and negative predictive value (NPV) of 94.54%, for the prediction of EPL in the training set. In the test set, point 5 had a sensitivity of 64.69%, specificity of 98.78%, PPV of 89.87% and NPV of 93.62%, and 93.91% of the cases were correctly predicted. Therefore, the simple scoring system using routinely collected data can be conveniently used for the prediction of EPL after ET.
Spatial Modeling of Groundwater Level in Bangladesh Using Physio-Climatic Variables: Machine Learning and Statistical Approaches
Authors: Kamal A S M Maksud , Fahim Abul Kashem Faruki , Shahid Shamsuddin 
Published: November 2022

Abstract
Groundwater monitoring is essential for sustainable groundwater resource management in a country like Bangladesh, where this precious resource is gradually declining due overextraction. Acquiring groundwater level (GWL) over a large area is time-consuming and expensive. This study proposes an alternative approach to groundwater monitoring using freely available daily groundwater storage (GWS) gridded data of the Global Land Data Assimilation System (GLDAS) with other freely available data, including population, rainfall, temperature, irrigation, elevation for modeling GWL data of Bangladesh with a spatial resolution of 0.25o × 0.25o. This was accomplished by employing multiple linear regression (MLR) and artificial neural networks (ANN), using weekly in-situ GWL data at 844 locations distributed over Bangladesh. The results showed the inability of GWS data to estimate the country's groundwater spatial variability and trend. The relative performance of MLR and ANN models revealed a higher capability of ANN in estimating GWL from GWS and other data with an overall correlation coefficient (R) of 0.95 and mean squared error (MSE) of 0.64. The study revealed population and rainfall have the most decisive influence in determining GWL. The model developed using ANN can be used to estimate GWL at locations where observation data are unavailable and thus monitor GWL for sustainable groundwater management.
Research on the spatial equity of medical facilities based on Rawls’ theory of justice: A case study of Nanchang, China
Authors: Xiong Zhiwei , Chen Wuying 
Published: November 2022

Abstract
Background: Under the impact of COVID-19, public health awareness and medical systems in various countries are facing significant changes. Such problems as unequal and unbalanced distribution of medical resources have become increasingly prominent. Therefore, building a scientific and reasonable equity evaluation system for urban public medical facilities layout optimization is of great research significance.
Methods: This paper introduces the improved potential model and uses the Baidu API navigation planning service to measure the spatial accessibility of medical care under two modes of transportation in Nanchang, and analyzes the spatial equity of medical facilities through the degree of accessibility equilibrium, accessibility adequacy and accessibility deprivation of vulnerable groups.
Results: In terms of accessibility equilibrium and adequacy, The study found a positive correlation between the accessibility of medical facilities and the level of medical services, and spatial equity was the worst in first-level hospitals. The results of the Mann-Whitney U test show that the communities with high housing prices in central city areas have better medical accessibility than those with low housing prices located on the urban fringes. In addition, owing to the high dependence of low-income people on public transport, marginalized urban communities have worse public transport than the central city, resulting in a dual deprivation of resources and location.
Conclusions: In practice, research on spatial equity of medical facilities should pay attention to the exploitation of medical resources of vulnerable groups, prioritize the planning and construction of primary hospitals (primary hospitals), and ensure residents’ demand for basic medical facilities, and step-by-step improvement of inequities in healthcare facilities.
Full-Duplex Multi-User MIMO Communication Systems Performance Optimization Using Leakage-based Precoding
Authors: Teklu Merhawit Berhane , Choi Dong-You , Meng Wei-Xiao 
Published: November 2022

Abstract
The spectral efficiency (SE) can approximately double when using full-duplex multiuser MIMO communications. However, there are difficulties because of multiuser interferences, self-interference (SI), and co-channel interference (CCI). To improve the SE of the DL, this paper proposes CCI-aware enhancement to SLNR (signal-to-leakage-and-noise-ratio) and considers a suppressing filter at the receiver to cancel the interferences again designing a beamformer based on CCI-plus-noise covariance matrices for every user at the transmitting side. Additionally, we propose an improvement in the SLNR method by using SI-plus-noise covariance matrices to design UL beamformers. Unlike zero-forcing and block-diagonalization, the SLNR approach serves numerous antennas at users and BS (base station). The total SE of the communication yielded using the optimized precoder, i.e., obtained from the SLNR-based precoding. To achieve the maximum EE, we use a power consumption model. Simulation results confirm that full-duplex performs well compared to half-duplex when the number of antennas at every user in uplink as well downlink channels grow, for all Rician factors, for slight powers of the CCI and SI, and a limited number of antennas at the BS. With the proposed scheme for given transmit power and circuit power, we demonstrate that FD has a higher EE than HD.
Thymoquinone, active constituent of Nigella sativa oil, against gastric cancer: A new hope of therapy.
Authors: Türkdoğan Kürşad , Koçyiğit Abdurrahim , Güler Eray Metin , Özer Ömer Faruk , Demir Kübra 
Published: November 2022

Abstract
Background

The oil and seeds of the famous medicinal herb Nigella sativa have been utilized for millennia. Its volatile oil contains thymoquinone, which has a variety of medicinal effects. We set out to investigate the effects of thymoquinone on human gastric adenocarcinoma cells, including its cytotoxic, genotoxic, apoptotic and ROS-producing characteristics.

Methods

The effects of a 24-hour exposure to thymoquinone at various dosages were investigated on a typical cell line of gastric cancer cells. Cytotoxicity, formation of reactive oxygen species and genotoxicity were evaluated by using the tests of ATP cell viability, 2',7'dichlorodihydrofluorescein-diacetate and alkaline single cell gel electrophoresis respectively. Western blotting and acridine orange/ethidium bromide staining were also used to identify the induction of apoptosis.

Results

Thymoquinone decreased gastric adenocarcinoma cells viability (80%) at the maximum concentration and also significantly induced apoptosis of gastric adenocarcinoma cells (80%) and DNA damage (nearly 100% ) in a dose dependent manner. Reactive oxygen species generation increased in a close negative relationship with cell viability, suggesting its pro-oxidant activity and it is thought to be a trigger mechanism for thymoquinone induced apopitosis.

Conclusions

Thymoquinone inhibited gastric adenocarcinoma cells’ proliferation and induced their apoptosis and DNA damage significantly. It seems to be a powerful and promising agent against gastric cancer in the near future.
Titanium (IV) oxide anatase nanoparticles as vectors for diclofenac: Assessing single and combined oxidative stress-related toxicity in the aquatic macrophyte Egeria densa
Authors: Esterhuizen Maranda , Lutsko Mariia , Kim Youngsam , Yoon Hakwon , Park Chang-Beom , Kim Young Jun , Pflugmacher Stephan 
Published: November 2022

Abstract
Titanium dioxide, frequently used in commonplace products, is now regularly detected in aquatic environments. Understanding its toxic effects on native biota is essential; however, combined toxicity with commonly occurring pollutants, such as the pharmaceutical diclofenac, may provide more insight into environmental situations. Therefore, the present study aimed to evaluate the effects of titanium dioxide and diclofenac, individually and combined, on the macrophyte Egeria densa. DCF uptake and removal were assessed. DCF and titanium dioxide toxicity were evaluated by assaying enzymes as bioindicators of biotransformation and oxidative stress. Cytosolic glutathione S-transferase and glutathione reductase activities were increased by diclofenac, titanium dioxide, and the combination. Both enzymes’ activities were more significantly elevated by diclofenac and the combination than nanoparticles alone. Microsomal glutathione S-transferase was unaffected by diclofenac exposure but inhibited with titanium dioxide and the mixture. Diclofenac elicited the most significant response. Based on the macrophytes’ vitality, the cytosolic enzymes effectively prevented damage.
Detection of tau-PET positivity in clinically diagnosed mild cognitive impairment with multidimensional features.
Authors: Li Bingyu , Shi Kening , Ren Chao , Kong Min , Ba Maowen 
Published: November 2022

Abstract
Background and purpose: The way to evaluate brain tau pathology in vivo is tau positron emission tomography (tau-PET) or cerebrospinal fluid (CSF) analysis. In the clinically diagnosed mild cognitive impairment (MCI), a significant proportion of tau-PET are negative. Interest in less expensive and convenient ways to detect tau pathology in Alzheimer's disease has increased due to the high cost of tau-PET and the invasiveness of lumbar puncture, which typically slows down the cost and enrollment of clinical trials. This study aimed to investigate one simple and effective method in predicting tau-PET status in MCI individuals.
Methods: Based on multidimensional data from MCI participants recruited by Alzheimer’s Disease Neuroimaging Initiative, we used stepwise regression to select the unitary or combination of variables that best predicted tau-PET. The sample included 154 individuals which were dichotomized into tau-PET (+) and tau-PET (-) using a cut-off of >1.33. The receiver operating characteristic curve was used to assess the accuracy of single and multiple clinical markers. The relative importance of predictive variables was judged by nomogram. At last, decision curve analysis (DCA) was used to evaluate the clinical diagnostic value of the best model.
Results: The combined performance of four variables [β-amyloid42 (Aβ42) , phosphorylated tau (p-tau), total tau (t-tau), β-amyloid42/β-amyloid40 ratio (Aβ42/40)] in cerebrospinal fluid biomarkers demonstrated the best predictive accuracy of tau-PET status [accuracy=84.3%, area under the curve (AUC) = 0.922], followed by neurocognitive measures using the combination of three variables [Alzheimer’s Disease Assessment Scale-Cognitive Subscale 13 (ADAS-Cog13), Mini-Mental State Examination (MMSE), ADNI-Memory summary score (ADNI-MEM)] (accuracy=85.7%, AUC = 0.879). Structural MRI also showed high accuracy in the middle temporal (accuracy=72.6%, AUC = 0.835). In addition, ADAS-Cog13 (AUC = 0.818) and ApoEε4 genotype (AUC=0.757) were the best independent predictors. The combination of clinical markers model (ApoEε4, neurocognitive measures and structural MRI imaging of middle temporal) had the best discriminative power (AUC=0.946).
Conclusions: As a noninvasive test, the combination of ApoEε4, neurocognitive measures and structural MRI imaging of middle temporal accurately predicts tau-PET status. The finding may provide a non-invasive, cost-effective and time-saving tool for clinical application in predicting tau pathology among MCI individuals.
Hydrogel capsules as new delivery system for Trichoderma koningiopsis Th003 to control Rhizoctonia solani in rice (Oryza sativa)
Authors: Cruz-Barrera Mauricio , Izquierdo-García Luisa Fernanda , Gómez-Marroquín Magda , Santos-Díaz Adriana , Uribe-Gutiérrez Liz , Moreno-Velandia Carlos Andrés 
Published: November 2022

Abstract
Biological control (BCAs) such as Trichoderma spp. minimize fungicides inputs in agriculture, and increase both the plant nutrition and the efficacy against fungal diseases. Novel bioproducts in crop management are called to guarantee sustainable antagonism activity of BCAs and increase the acceptance of the farmers. The encapsulation in polymeric matrices play a prominent role for providing an effective carrier/protector and long-lasting bioproduct. This research aimed to compare two hydrogel capsules prototypes based on alginate (P1) and amidated pectin (P2), containing Trichoderma koningiopsis Th003 conidia. Capsules were prepared by the ionic gelation method and calcium gluconate as crosslinker was used. The capsules were characterized by various properties such as conidia releasing at different pH values, drying conidia survival, storage stability, and biocontrol activity against sheath blight (R. solani) in rice. P2 prototype provided higher survival to Th003 up to 98% in fluid bed drying, faster conidia release at pH 5.8, storage stability > 6 months at 18°C, and a disease reduction up to 67%. Amidated pectin provides advantages on drying survival and conidia release at pH 5.8. Both biopolymers facilitate the antagonistic activity against R. solani, and therefore can be incorporated in hydrogel capsules for novel bioinoculants development. This research highlights the knowledge regarding the influence of biopolymer in hydrogel capsules on survival and shelf-life of Trichoderma spp conidia.
Haplotype of CaSR gene is associated with risk of Renal Stone Disease in West Indian Population
Authors: Patel Yash P , Pandey Sachchida Nand , Patel Sandip B , Parikh Aditya , Soni Shailesh , Shete Nitiraj , Srivast Ratika , Raval Manan A , Ganpule Arvind P , Patel Samir G , Desai Mahesh R 
Published: November 2022

Abstract
Purpose
Calcium is the most abundant metabolite involved in the stone matrix. The CaSR gene controls calcium homeostasis, and genetic variation in the CaSR gene could lead to the development of renal stone disease. Therefore, the current study has been designed to assess the association of genetic variants of CaSR gene polymorphisms with renal stone disease.
Method
A single-centric prospective study has been carried out on a total of 300 participants (150 cases and 150 controls). Serum levels of calcium, creatinine, parathyroid hormone, and 24 Hour urine metabolites were measured. Two polymorphisms, rs1801725 and rs1042636, of the CaSR gene, have been genotyped for each participant. T-test, Chi-square, and Receiving Operative Curve (ROC) curve analysis were used for statistical analysis.
Result
Renal stone patients had significantly higher levels of serum parathyroid hormone, creatinine, and 24hr urine metabolites in comparison to the controls. CaSR gene variants rs1801725 (GG) and rs1042636 (AA) both have shown significant association with renal stone disease. In addition, individuals having specific genotypes along with metabolic abnormalities such as hypercalcemia, and hyperparathyroidism are found to be at a higher significant risk of developing the renal stone disease. Further, ROC analysis also showed a higher risk (54%) for individuals carrying the GG/AA haplotype.
Conclusion
In the present study, the haplotype of the CaSR gene has shown an association with renal stone disease. Individuals with hyperparathyroidism and hypercalcemia and risk genotype have a higher susceptibility to developing the renal stone disease.
Necroptosis-related lncRNAs signature predicts prognosis and influences immune microenvironment in patients with colon adenocarcinoma
Authors: Xu Zijie , Liu Jingya , Wang Yiwen , Shen Haoyang , Zhu Lingjun , Shu Yongqian 
Published: November 2022

Abstract

Background: The present study aimed to identify an NRLs (necroptosis-related long noncoding RNAs [lncRNAs]) signature for the prognosis of colon adenocarcinoma (COAD) and to investigate its potential relationship with clinical characteristics and immune microenvironment.
Methods: Clinical information of patients with COAD and RNA sequence data were downloaded from The Cancer Genome Atlas (TCGA) database. Necroptosis-related genes (NRGs) were obtained from the GeneCards website. Co-expression analysis was performed to identify NRLs. By using the “limma” package in R software, differentially expressed NRLs (DE-NRLs) were screened from the identified NRLs. A prognostic NRLs signature was established based on the results of univariate Cox regression analysis, LASSO algorithm, and multivariate Cox analysis. Survival analysis and area under the curve (AUC) of receiver operating characteristic (ROC) were used to evaluate the prognostic efficacy of this signature. Clinical correlation and independent prognostic factors were then assessed, and a predictive nomogram was then constructed. Finally, gene set enrichment analysis (GSEA) was conducted to determine the potential molecular mechanisms. Immune analysis was performed to analyze the tumor microenvironment and to predict the immune response of patients with COAD. Lastly, experiments were conducted to validate the expression and function of NRLs involved in the prognostic signature.
Results: Three NRLs were identified, and a prognostic signature was constructed from them. According to the risk score calculated using this signature, patients were classified into high-risk and low-risk groups. The signature exhibited a strong ability to predict survival, and the risk score was confirmed as an independent prognostic factor. GSEA showed differences in specific molecular pathways involved in immune response, mitochondrial function, and energy metabolism. The two groups also showed significant differences in immune cell infiltration, immune function, and immune checkpoint gene expression. The high-risk group showed higher immunogenicity and may benefit from immunotherapy. Lastly, in vivo experiments validated the expression and function of NRLs involved in the prognostic signature.
Conclusions: The prognostic signature of NRLs developed in this study can facilitate the clinical diagnosis and treatment of patients with COAD and may serve as a valuable reference for in-depth studies of functional mechanisms of NRLs in the immune microenvironment.
Suitability evaluation of human settlements using a global sensitivity analysis method: A case study in China
Authors: Wu Feifei , Yang Xiaohua , Kang Jing , Lian Bing , Wang Yan 
Published: November 2022

Abstract
The suitability evaluation of human settlements over time and space is essential to track potential challenges towards suitable human settlements and provide references for policy-makers. This study established a theoretical framework of human settlements based on the nature, human, economy, society and residence subsystems. Evaluation indicators were determined with the consideration of the coupling effect among subsystems. Based on the extended Fourier amplitude sensitivity test algorithm, the global sensitivity analysis that considered the coupling effect among indicators was used to determine the weights of indicators. The human settlements suitability was evaluated at both subsystems and comprehensive system levels in 30 provinces of China between 2000 and 2016. The findings were as follows: (1) human settlements suitability index (HSSI) values increased significantly in all 30 provinces from 2000 to 2016. Among five subsystems, the suitability index of the residence subsystem in China exhibited the fastest growing, followed by the society and economy subsystems. (2) HSSI in eastern provinces with developed economy was higher than that in western provinces with underdeveloped economy. In contrast, the growing rate of HSSI in eastern provinces was significantly higher than that in western provinces. (3) The inter-provincial difference of HSSI decreased from 2000 to 2016. For subsystems, it decreased for the residence system, whereas it increased for the economy system. (4) The suitability of the natural subsystem has become a limiting factor for the improvement of human settlements suitability, especially in economically developed provinces such as Beijing, Shanghai, and Guangdong. The results can be helpful to support decision-making and policy for improving the quality of human settlements in a broad nature, human, economy, society and residence context.