bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial synergistic effects of dietary flavonoids rutin and quercetin in combination with antibiotics gentamicin and ceftriaxone against E. coli (MDR) and P. mirabilis (XDR) strains isolated from human infections: Implications for food–medicine interactions
Authors: Alnour Tarig M.S. , Ahmed-Abakur Eltayib H. , Elssaig Elmutuz H. , Abuduhier Faisel M. , Ullah Mohammad Fahad 
Published: April 2022

Antimicrobial resistance has emerged as a major global concern for public health in the last two decades, which tends to compromise the existing drug regimens in treating common or severe infections. According to WHO, three million laboratory-confirmed bacterial infections have been reported from 70 countries in 2019, caused by pathogens of concern. The drug-resistant bacterial strains are characterized as multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan drug-resistant (PDR) based on the different patterns of resistance. It is believed that novel strategies are essentially required to counter and eliminate drug resistance in a cost-effective manner to benefit the world population. Natural compounds and certain dietary agents show potential antimicrobial properties and these have been used since ancient times to treat human infections. In this study, we have investigated the synergistic effects of dietary flavonoids rutin and quercetin with antibiotics gentamicin (an aminoglycoside) and ceftriaxone (a third-generation cephalosporin) against the drug-resistant superbugs; clinical isolates including Escherichia coli (MDR), Proteus mirabilis (XDR), and Klebsiella pneumoniae (PDR). Conventional MIC assay and checkerboard test were used as standard protocols. Our results show that rutin and quercetin restore the antimicrobial activity of the antibiotics against MDR and XDR strains, while no such effect was observed in the case of the PDR strain. Quercetin, which is a aglycone of flavonoid rutin, demonstrates higher synergistic effects with ceftriaxone compared to rutin. Since rutin and quercetin are essentially present in human diets as constituents of fruits and vegetables, their use as nutraceuticals in adjuvant therapies in combination with antibiotics against drug resistance is a promising therapeutic strategy against superbug infections.
De la teoría a la práctica: el fenómeno del lavado de activos en el Tolima (2005-2015)
Authors: Hernández Quintero Hernando A. , Vargas Sanmiguel Constanza , Vargas Nieto Tatiana 
Published: April 2022

El presente artículo pretende establecer la aplicación del marco normativo, administrativo y penal antilavado de activos, teniendo como ámbito espacialel departamento del Tolima y como marco temporal, el decenio 2005- 2015. Con este fin, se ha implementado la metodología cualitativa sobre la información normativa recopilada, así como mixta en relación con los demás datos provenientes de la Unidad de Información y Análisis Financiero(UIAF), el Departamento Administrativo Nacional de Estadística (DANE) y del trabajo de campo en la jurisdicción penal de la región. Se cuentan como resultados la recopilación normativa en orden cronológico del ámbito administrativo y penal más relevante, descendiendo en el estado actual del fenómeno bajo estudio; también se registra la información disponible hasta 2014 sobre el número de reportes de operaciones sospechosas (ROS) en el sector financiero y real por años, sin discriminación por departamentos ante la negativa de las entidades públicas para dar acceso a estos datos por considerar que los mismos son objeto de reserva. En el ámbito judicial del departamento se encontraron cinco procesos por lavado de activos enel periodo estudiado. Se propone entre las conclusiones que, ante la hipótesis de un marco normativo inoperante para combatir el lavado de activos en laregión, lo que arroja la investigación es la existencia de un marco jurídico sólido, pero al parecer, una escasa ocurrencia del fenómeno criminal. No es posible realizar estudios que incluyan variables más precisas, salvo que las entidades del Estado ofrezcan mayores datos por región, hasta ahora protegidos por reserva legal según se aduce.
Conocimiento sobre las aplicaciones del mindfulness a la mediación de conflictos: revisión bibliográfica mixta
Authors: Díez David , Romero Cárdenas Roberto Mauricio 
Published: April 2022

El artículo revisa las aplicaciones del mindfulness en la mediación de conflictos. Se estableció el estado del conocimiento mediante la metodología de revisión bibliográfica mixta, con análisis bibliométrico y codificación de publicaciones indexadas en Scopus. Estas provienen de áreas como la medicina, la psicología y el derecho, para conformar un campo interdisciplinar emergente con enfoques teóricos orientales y occidentales. Los primeros sirven para gestionar emociones negativas de las contrapartes y sesgos del mediador; los segundos para identificar intereses comunes e idear soluciones ante conflictos ciudadanos, familiares, corporativos y sociopolíticos. Así, se trasciende del imaginario del abogado como “gladiador” al de “constructor depaz”. Bajo tales hallazgos, se recomienda realizar estudios empíricos sobre el grado de apertura ante la aplicación del mindfulness en la mediación; asimismo, promover la formación en mindfulness para abogados, profesionales de áreas afines y mediadores comunitarios en tanto constructores de paz en contextos sociales de alta conflictividad.
A New Model for Vertical-to-Horizontal Response Spectral Ratios for Central and Eastern North America
Authors: Pezeshk Shahram , Farhadi Ali , Haji-Soltani Alireza 
Published: April 2022

ABSTRACT
It is a well-known fact that critical structures are required to be designed for the vertical effects of earthquake ground motions as well as the horizontal effects. We developed a new model for the spectral ratio of vertical-to-horizontal components of earthquakes (V/H ratio) for central and eastern North America (CENA). The proposed V/H ratio model has the advantage of considering the earthquake magnitude, source-to-site distance, and the shear-wave velocity of soil deposits in the upper 30 m of the site for peak ground acceleration and a wide range of spectral periods (0.01–10.0 s). The model evaluation is based on a comprehensive set of regression analysis of the compiled Next Generation Attenuation-East database of the available CENA recordings with M ≥ 3.4 and Rrup&lt;1000  km. The median value of the geometric mean of the orthogonal horizontal motions rotated through all possible nonredundant rotation angles, known as the RotD50, is used along with the vertical component to perform regression using the nonlinear mixed-effect regression. We excluded the earthquakes and recording stations in the Gulf Coast region due to their different ground motion attenuation (Dreiling et al., 2014). To compute V/H ratios for the Gulf Coast region, we refer the readers to the study of Haji-Soltani et al. (2017). Moreover, we excluded the National Earthquake Hazard Reduction Program site class E sites from consideration because of their complex site response characteristics and their potential for nonlinear site effects. The predicted V/H ratios from the proposed model are compared with recently published V/H ratio models. We suggest our model to be used for developing the vertical response spectra for CENA sites.
Assessing the Accuracy of a Borehole-Controlled P-Wave Velocity Model of Yucca Flat, Nevada Using Large-N Seismic Data
Authors: Vieceli Rhiannon E. , Abbott Robert E. , Preston Leiph A. 
Published: April 2022

ABSTRACT
With geologic data from over 950 boreholes, Yucca Flat basin, residing on the Nevada National Security Site, has excellent borehole control on stratigraphy. These data were used to create a Geologic Framework Model (GFM) of the basin. Of these boreholes, 188 have corresponding downhole seismic survey data, which were used to determine average P-wave velocities of the geologic units and create a GFM seismostratigraphic model (GFM-SS). With the acquisition of six new active-source large-N datasets in Yucca Flat, we can now quantitatively assess the accuracy of the GFM-SS previously controlled only by borehole data. For each of the six datasets, we subset the GFM to the region of interest and create a forward model of P-wave travel times for the GFM-SS given the large-N source-receiver geometries. We first made trial-and-error adjustments to the unit velocities (while keeping the layer geometry intact) to improve the travel-time residuals. We then implemented a simulated annealing approach to find the optimal velocity model for each dataset. Our results indicate that the borehole-controlled model overestimates alluvium velocities across Yucca Flat. This result persists even when we make smaller GFM-SS models that are local to individual large-N experiments. We hypothesize that this result is a combination of shorter ray paths and the resulting lack of interaction with large-scale features (such as faults), as well as less attenuation of high frequencies in the borehole data. Both the current GFM-SS and the updated model based on median velocities that we present here overgeneralize local unit velocities, which can be quite heterogeneous in Yucca Flat.
DESAIN USER INTERFACE GAME FAIRPLAY POKER MENGGUNAKAN METODE UCD (USER CENTERED DESIGN)
Authors: Bastian Henry , Saputro Godham Eko , Yogananti Auria Farantika 
Published: April 2022

Abstract: In Indonesia, one of the favorite online game is poker. Poker is a card game with some rules that can be played directly or via the internet. Online Poker game is one of the effective media to spend time and amuse pleasure by playing poker with peoples. The Infamous Poker game known is Zynga poker. From the data search that had been done, the game still has a few weaknesses in the heavy User Interface that the authors try to develop a similar user interface poker game. Which name the Fairplay Poker using UCD (User-Centered Design) methodology. A design resulted in an illustration designed in 2D that can improve loading with lighter.Key Words: Game, User Interface, Fairplay Abstrak: Di Indonesia, salah satu permainan yang menjadi kegemaran adalah bermain game Poker. Poker merupakan permainan kartu aturan yang dapat dimainkan secara langsung maupun lewat internet. Game Poker online adalah salah satu sarana efektif untuk menghabiskan waktu sekaligus hiburan kesenangan bermain poker dengan banyak orang. Salah satu game Poker yang terkenal adalah Zynga Poker. Dari pencarian data yang dilakukan ditemukan bahwasannya permainan tersebut masih mempunyai kekurangan pada bagian user interface yang berat dan memiliki beberapa kekurangan sehingga penulis mencoba untuk membuat User Interface game poker online sejenis menggunakan metode UCD (User-Centered Design) dengan nama FairPlay Poker. Desain yang dihasilkan adalah desain ilustrasi 2D yang dapat digunakan dengan lebih ringan.Kata kunci: Game, User Interface, Fairplay
Teachers’ Perception of an Online Learning System
Authors: Hasanah Kuswatun , Supentri Supentri , Erlinda Sri 
Published: April 2022

This study is aimed to monitor teachers perception of an online learning system during the pandemic covid-19 at SMPN 4 Mandau. This study used a descriptive-quantitative design. In the data collection technique, it used observation, an online questionnaire consists of indicators with 20 questions and interviews. The population of this study is all teachers at SMP N 4 Mandau, Bengkalis Regency, Riau Province. Then, the samples were taken by using the total sampling technique. The result showed that the respondents answered Strongly Agree and Agree referred to 66.71 percent with a presence in the range of 50.01-68.00 percent. Thus, teachers perception of online learning at SMP N 4 Mandau was Quite Good.
Fun POAC, A Learning Media for Human Resources Course
Authors: Bukhori Imam , Nora Elfia , Sopiah Sopiah 
Published: April 2022

This type, of course, consists of compulsory courses, prerequisites, concentrations, and electives. Human Resource Management courses are compulsory courses that must be followed by all undergraduate students of the Department of Management at the Faculty of Economics, Malang State University. The development of Fun POAC Human Resources Application as an e-learning medium in this human resource management course is to create and develop electronic learning media which will be able to make it easier for students to understand how planning, organizing, moving, and controlling human resources in an organization, Making learning in resource management courses is not boring and interesting because it is not only encouraged in listening to what lecturers say but is packed with application devices with various accessories and interesting features that can make students motivated to open, read and understand learning materials, assignments and practices. The material on the application is packaged for one semester lectures. The e-learning media developed consists of fun planning HR, Fun Organizing HR, Fun Actuating HR, and fun controlling desktop-based menus so that students or those who want to use this application can install it on their respective computers or laptops. The development method carried out is the Borg &Gall development model (2005) using waterfall grooves(waterfall)at the stage of development. The development stages start from needs analysis, product planning, product development, trial/implementation (validation), revision, and report creation. The product results in the form of the "Fun POAC Human Resources" Application as a learning medium in human resource management courses and will be equipped with media application videos, as well as media usage instructions.
A study of preoperative factors predicting a difficult laparoscopic cholecystectomy
Authors: Bansod Atish N. , Patil Ishwar G. , Awachar Neha S. , Umalkar Rohan K. , Wankhede Abhijit M. , Jadhav Vaishnavpriya K. 
Published: April 2022

Background: Laparoscopic cholecystectomy is considered the gold standard treatment for most gallbladder diseases. It has now become one of the most common operations performed by general surgeons. At times, it is difficult and takes longer time or some complications may occur or has to be converted in to open cholecystectomy. This study is undertaken to determine predictive factors for difficult laparoscopic cholecystectomy. The aim of the study was to study pre-operative factors in the patients to predict whether the laparoscopic cholecystectomy will be easy or difficult. And to co-relate the pre-operative factors predicting a difficult Laparoscopic Cholecystectomy with intra-operative findings.Methods: This prospective study was carried out in the Department of General Surgery in IGGMC, Nagpur, Maharashtra, India over a period of 2.5 years. Total 52 patients were included in the study. All patients were evaluated for risk factors preoperatively and intraoperative findings were noted. A chi-square test has been used to find the significant association of findings of the preoperative score with postoperative outcome.Results: History of hospitalization for gall stone diseases, ultrasound abdomen showing gall bladder wall thickness >4 mm, presence of pericholecystic collection, and impacted stone can be considered as individual significant positive predictive factors to predict a difficult laparoscopic cholecystectomy preoperatively. While age >50 years, gender, BMI >25 kg/m2, and history of supraumbilical surgery/scar can’t be considered as an individual positive predictive factor.Conclusions: A uniform scoring system needs to be assessed and thoroughly evaluated by combining all these factors to predict a difficult laparoscopic cholecystectomy.
Large Multiple Sialoliths of Bilateral Submandibular Glands: A Case Report
Authors: Barzegar Mohsen , Pouyafard Adele , Ajami Hamidreza , Pakzad Sahar 
Published: April 2022

Sialolithiasis is a most common disease of salivary glands most commonly occurs in submandibular gland system. Simultaneous sialolithiasis in more than one salivary gland and multiple stone formations have been reported in only 5% and 3% of cases, respectively. In this article, a rare case of bilateral presence of various stones in different sizes and shapes in the submandibular glands and its duct in a 68-year-old man has been investigated. Stones on left side were removed through an intraoral incision and on the right side; the entire salivary gland was removed with extraoral access.
Conclusion: After precise diagnosis of sialolithiasis through various diagnostic modalities, treatment plan should be tailored based on existing condition and the decision was made to remove a salivary gland with extraoral access on one side and remove the stones by intraoral incision on the other side while preserving the salivary gland.
Frequency of Latent Tuberculosis Infection in Patients with Type 2 Diabetes referred to Shahid Rahimi Hospital in Khorramabad City with Tuberculin Skin Test in 2018-2020
Authors: Mousavi Mahshad , Mousavi Nazanin , Abdollahian Majid , Kaviani Mozhgan 
Published: April 2022

Introduction: Tuberculosis is the leading cause of death from infectious diseases worldwide. Diabetes has been suggested as an important risk factor for tuberculosis. To date, few studies have examined the association between diabetes and tuberculosis. In this study, the prevalence of latent tuberculosis in diabetic patients was investigated.
Methods: In this study, 195 patients with type 2 diabetes were studied in a cross-sectional study to diagnose latent tuberculosis infection with a tuberculin skin test. Individuals with symptoms of active tuberculosis were excluded from the study, and individuals with a positive tuberculin test were evaluated for active tuberculosis by chest x-ray. For analyzing the data, SPSS software version 16 was run, a t-test was used to analyze quantitative variables, and for qualitative variables, Chi-square was applied. The significance level of 0.05 was considered for all the results.
Results: Out of 195 diabetic patients, 115 patients were referred for tuberculin test results. 43 out of 115 patients (37.39%) had an induration diameter greater than or equal to 5 mm, 29 patients (25.21%) had an induration diameter greater than or equal to 8 mm, and 3 patients (2.61%) had an induration diameter greater than or equal to 10 mm (Positive tuberculin test) (p>0.05).
Conclusion: False tuberculin skin test results can hide the true prevalence of latent tuberculosis infection. The sensitivity of the tuberculin test decreases in immunocompromised patients and leads to limitations in assessing the prevalence of latent tuberculosis infection. Although not enough information was available in this study to establish a significant association between diabetes and latent tuberculosis infection, further studies will help to investigate this association.
Teori Produksi Berdasarkan Perspektif Islam
Authors: Habibulloh  
Published: April 2022

Abstract
Production activity is a mandatory thing to do in order to meet all human needs and to take advantage of the availability of natural resources to fulfill all what is needed by humans by producing them and processing them. In Islam itself, it is also explained about being a good producer based on the theory of production in Islamic economics. Therefore, this journal aims to provide a general description and knowledge of the general public and especially for producers to understand the flow of the Islamic religion in explaining production theory and regulating it. The method used to describe this research is descriptive qualitative method, meaning that the technique used in this research is a literature study that focuses on finding information from journals, books or other forms of writing. The results of this study are a producer in the view of Islam has limits in production, but this limitation does not only apply to creativity but also to the prohibition on producing illicit goods. Basically, conventional theory and sharia have differences in terms of the amount, revenue and costs themselves, in conventional production theory also recognizes the interest system which is contrary to sharia production theory which recognizes profit sharing.
Kredit Usaha Rakyat dan Perkembangan UMKM di Kabupaten Simeulue Pasca Covid-19
Authors: Syamsuar Syamsuar , Ikhwan M. , Sabi Marchi Raida 
Published: April 2022

Abstract :
People's Business Credit (KUR) is a form of government program in increasing access to financing for Micro Small and Medium Enterprises (MSMEs) with low-interest rates, this program is channeled through financial institutions with guarantee patterns. KUR funds are given to people who have productive businesses with varying amounts to the business conditions involved, but during the covid-19 pandemic, the MSME sector also experienced the difficulty of installment returns, so this study was conducted to answer two fundamental questions, are: how KUR funds in the review of sharia economic law and how the fate of MSMEs during the covid-19 pandemic in Simeulue Regency. This research is qualitative research and data collection techniques using observation, interview, and documentation, while data analysis uses descriptive techniques. Based on the results of research it can be concluded that in the incarnation of Sharia economic law regarding KUR there are two opinions, first declaring the law haram because it includes riba, while the second opinion asserts that the legal KUR can and does not include riba. The difference lies in whether or not the interest of the KUR. Then the influence of covid-19 on MSMEs in Simeulue Regency is bad for the development of community businesses due to the lack of buyer interest so that the weakening of their income and the effect on delayed installment payments beyond the due date.
Services Responding to Domestic Violence Survivors’ Needs: A Study of Pennsylvania Providers’ Perspective
Authors: Sharma Yasoda , Vafeas John 
Published: April 2022

This research examined domestic violence services and programs provided in rural and urban Pennsylvania. It identified the potential gaps in services and assessed programs adequacies from the perspective of program leaders. The study examined the needs and characteristics of both agencies and their clients. In addition, barriers to effective delivery of domestic violence services in Pennsylvania was examined.
A Structured questionnaire was used as a primary method of data collection and explored answers for research question on the challenges and opportunities Domestic Violence agencies’ leaderships experiences in providing services. Sampling frame included 60 service providers from Pennsylvania, of which 45 agencies serving the survivors of Domestic Violence participated. Funding for this research was provided by a University grant and the partnership with Pennsylvania Coalition Against Domestic Violence provided technical assistance and access to agencies. The agency leaders who agreed to participate were contacted and both in person and telephonic interviews were conducted. The interview lasted for about 45 -60 minutes.
The study found that there is a wide consensus among leaders that transportation and transitional housing services are inadequate in their program service areas while services like crisis hotline, general advocacy and case management are exceptional.
Over 50% of the agencies did not comment on the adequacies of the services such as Job Coaching, Immigrations services, Divorce/Custody representation, and Criminal Court representation.
The results have several policy implications regarding federal and state government programs, specifically considerations to fund transportation, transitional housing and legal advocacy services.