bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolución de las características de la citación en las monografías
Authors: Vega Almudena Mangas 
Published: June 2022

Se estudia la evolución de la no citación, uno de los aspectos que tienen un impacto reconocido en los resultados bibliométicos. Se pretende profundizar en la afectación producida por el tipo de documento, el área del conocimiento, el tiempo (que durante décadas se ha medido a través de la vida media), o el envejecimiento de las citas dentro del ámbito de las monografías científicas, en el que siguen apareciendo críticas a los sistemas de evaluación actuales y en el que se está trabajando sin descanso para lograr mejorar esa situación que afecta de forma significativa a algunas áreas del Conocimiento. Para la consecución de los objetivos se toman los estudios de Rong Tang (2008) y de Jeppe Nicolaisen y Tove Faber Frandsen (2019), y, tras las necesarias normalizaciones, réplicas de pasos y tratamiento de los datos, se analizan comparativamente desde el punto de vista de dicha evolución. Los resultados sugieren una relación entre las ratios de no citación y la tipología documental; permiten una mejor comprensión del panorama actual de la publicación y uso de la información científica; y, convierten a la ratio de no citación en un elemento con posibilidades de uso como parámetro para la medición del mayor o menor impacto de las monografías científicas.
Factors associated with practices of health care workers towards integrating oral health into primary health care in Imenti North District, Kenya
Authors: Kaguru George Kariuki 
Published: June 2022

Purpose: The prevalence of oral health diseases is on the rise in Kenya. The ratio of oral health care personnel to the population is however very low. Preventive dentistry remains is therefore key to reverse this trend. Integration of oral health into primary health care would utilize the non-oral health care providers to achieve the primary goal of preventive dentistry. Key to this integration is the knowledge, attitude and practices of health workers on their roles.
Design/ Methodology/Approach: This was a cross-sectional study among medical doctors, nurses and clinical officers in Imenti North District, Kenya. A self-administered questionnaire was used to assess their knowledge, attitude and practices on the three roles in integration, that is, diagnosis, oral health education and referral. A total of 214 participants took part in the study. Analysis for association was done using Chi-square, odds ratio, Fisher's exact test and logistic regression.
Findings: Social demographic characteristics do not influence the provision of oral health services by non-oral health care providers. Provision of resources and equipment including referral guidelines on oral health, face masks and tongue depressors influenced the provision of oral health services. Similarly, the availability of a dentist influenced the decision to refer patients who had suspected dental diseases. Adequate knowledge by health workers on their role did not always result in the provision of oral health services mainly due to a lack of hands-on experience.
Contribution to policy and practice: The findings of this study will help Health care providers in the Imenti North district provide resources and equipment, train in-service health care workers in oral health and provide on-job skills training to health care workers to convert knowledge in oral health into practice.
Originality/Value: This study is the first to empirically establish factors associated with practices of health care workers towards integrating oral health into primary health care.
THE DYNAMIC OF SERUM CYTOKINES IN PSORIASIS PATIENTS TREATED WITH SECUKINUMAB
Authors: Hao Nguyen Trong , Nguyen Pham Nhat 
Published: June 2022

Introduction: Immunological mechanisms of psoriasis have been discussed widely in literature, including cytokines. There are relationships between serum IL-17A, IL-12, and TNF-α with psoriasis, and IL-17A is one of the target cytokines novel biologic therapies. The efficacy, safety, and mechanism of secukinumab were well known while the actual dynamic of circulatory cytokines is less well studied.
Objectives: To study the dynamic of serum IL-17A, IL-12, and TNF-α in adult moderate-to-severe plaque psoriasis patients being treated with secukinumab in Ho Chi Minh City Hospital of Dermato-Venereology from July 2019 to May 2020.
Subjects and methods: We performed a case series on 35 patients in Ho Chi Minh City Hospital of Dermato-Venereology in the aforementioned period.
Results: Despite the patients’ well response to the secukinumab, the concentration of the three cytokines of interest at baseline did not relate to age, sex, age of onset, family history of psoriasis, BMI, metabolic syndrome, history of treatment, or achieving IGA 0/1 at week 12 (p ≥ 0.05). IL-17A and IL-12 correlation at the baseline was statistically significant (p=0.029, r = 0.37). Serum IL-17A and IL-12 were higher at week 12 compared to one at week 4. TNF-α increased at week 12 comparing to one at the baseline. All increases were statistically significant (p<0.05).
Conclusion: The paradoxical dynamics of the cytokines while treating psoriasis with secukinumab might potentially cause relapse and/or flare of psoriasis after stop using this agent. Although anti-IL-17A has high efficacy in the treatment of psoriasis, measuring the serum concentration of IL-17A at baseline may not have any essential role in predicting the response of psoriasis to secukinumab.
ĐIỀU TRỊ VIÊM DA DẦU NGƯỜI LỚN MỨC ĐỘ VỪA VÀ NẶNG BẰNG UỐNG ITRACONAZOL VÀ BÔI TACROLIMUS
Authors: Trung Lê Văn , Hiền Đỗ Thị Thu , Lượng Vũ Huy 
Published: June 2022

Mục tiêu: Đánh giá hiệu quả điều trị viêm da dầu người lớn mức độ vừa và nặng bằng uống itraconazol có và không duy trì kết hợp với bôi tacrolimus và gội đầu bằng dầu AIAFp.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu can thiệp so sánh trên 62 bệnh nhân viêm da dầu người lớn mức độ vừa và nặng được chia làm 2 nhóm: nhóm 1 điều trị bằng uống itraconazol 200mg/ngày x 7 ngày sau đó từ tháng thứ 2 uống duy trì 200 mg/ngày x 2 ngày đầu tháng x 3 tháng, nhóm 2 điều trị bằng uống itraconazol 200 mg/ngày x 7 ngày và không uống liều duy trì. Cả 2 nhóm đều được điều trị kết hợp bằng dầu gội đầu có hoạt tính chống viêm chống nấm AIAFp, bôi tacrolimus 0,1% ngày 1 lần buổi tối và dưỡng ẩm. Hiệu quả điều trị được đánh giá bằng sự cải thiện các triệu chứng lâm sàng và cơ năng theo thang điểm Avner Shemer1 tại các thời điểm sau 2 tuần, 4 tuần và so sánh kết quả điều trị giữa 2 nhóm sau 8 tuần, 16 tuần.
Kết quả: Sau 2 và 4 tuần điều trị, các triệu chứng đỏ da, vảy da, ngứa, rát bỏng giảm rõ rệt. Tổng điểm triệu chứng trước điều trị giảm lần lượt từ 7,44 xuống 1,76 và 1,79 sau 2 và 4 tuần. Có 82,3% và 77,4% bệnh nhân đạt kết quả điều trị từ tốt trở lên sau 2 tuần, sau 4 tuần điều trị trong đó tỷ lệ hiệu quả điều trị rất tốt lần lượt là là 11,3% và 12,9%. Nhóm điều trị duy trì itraconazol sau 8 tuần và 16 tuần có lần lượt 74,2% và 71% bệnh nhân có hiệu quả điều trị từ tốt trở lên so với 35,5% và 12,9% bệnh nhân trong nhóm điều trị không duy trì (p<0,05). Tỷ lệ tái phát viêm da dầu trong nhóm điều trị duy trì itraconazol sau 8 tuần, 16 tuần là 12,9% và 25,8% thấp hơn so với 41,9% và 71% trong nhóm điều trị không duy trì (p<0,05).
Kết luận: Điều trị viêm da dầu người lớn mức độ vừa và nặng bằng uống itraconazol và bôi tacrolimus cho kết quả điều trị tốt. Nghiên cứu cũng cho thấy uống itraconazol liều duy trì có hiệu quả hơn liều không duy trì, hạn chế được sự tái phát bệnh.
Morcegos do Tocantins: lista de verificação de espécies
Authors: Souza Marcelino Benvindo , Santos Cirley Gomes Araújo , Silva Gianieily Alves Flausino de Queiroz , Alves Ana Paula Silva , Assis Rhayane Alves de , Santos Lia Raquel de Souza , Borges Rinneu Elias , Pacheco Susi Missel 
Published: June 2022

A composição de morcegos nos estados brasileiros vem sendo reportada. Porém, muitas regiões ainda permanecem desconhecidas e, nesse sentido, apresentamos a primeira lista de morcegos para o estado do Tocantins baseado em uma revisão de literatura, de modo a diminuir as lacunas de conhecimento sobre essa diversidade. Sistematicamente, a produção científica com quirópteros para o Tocantins é bastante recente, com aproximadamente 16 anos. Um total de 86 espécies foi documentado, pertencentes as nove famílias ocorrentes no Brasil. Lacunas de conhecimento são detectadas, principalmente, nas regiões norte, noroeste e nas extensões oeste, sudoeste e nordeste. Esforços de amostragem utilizando acústica como novos métodos de amostragens são recomendados para elevar ainda mais a riqueza de animais. Sugerimos que, no futuro, cientistas da conservação, além de analisar a composição de espécies, análise da paisagem, possam também obter variáveis ecotoxicológicas para relacionar à segurança ambiental. A partir dessas análises poderão compreender a interação dos efeitos dos xenobióticos tanto na saúde desses mamíferos como na qualidade ambiental.
Modelagem matemática como suporte à gestão dos recursos hídricos na bacia hidrográfica do rio Araçuaí (MG)
Authors: Martins Geovana Magdália de Freitas , Couto Eduardo de Aguiar do , Marques Gláucio Marcelino 
Published: June 2022

O monitoramento e a adoção de ferramentas que auxiliem na tomada de decisões são fundamentais para a boa gestão da qualidade das águas de uma bacia hidrográfica. Diante disso, o presente trabalho utilizou o modelo matemático QUAL-UFMG com o objetivo de avaliar a capacidade de autodepuração do rio Araçuaí, em Minas Gerais, analisando as variáveis oxigênio dissolvido (OD) e demanda bioquímica de oxigênio (DBO) considerando os anos de 2016, 2017 e 2018 para calibração e o ano de 2019 para validação do modelo. Posteriormente foi simulado um cenário hipotético, considerando a implantação de estações de tratamento de esgoto com uma eficiência de 85% de remoção de DBO para todos os municípios da bacia que ainda não se encontram em operação, até o ano de 2033, tendo como base o Plano Nacional de Saneamento Básico - PLANSAB. Os resultados do modelo mostraram que tanto o processo de calibração quanto o de validação apresentaram bons resultados em relação ao índice RMEQ. Observou-se que a qualidade da água, após o lançamento de efluentes do município de Itamarandiba, não satisfaz as condições estabelecidas pela Resolução CONAMA 357/2005 no que diz respeito à variável DBO. Para a variável OD não foi constatada a desconformidade com a Resolução. A partir da simulação do cenário, observou-se que a implantação de ETE’s para todos os municípios que ainda não possuem o tratamento de esgoto, faria com que a variável DBO atendesse os limites permitidos pela legislação para águas doce classe 2. Observou-se também que se a implantação da ETE fosse apenas no município de Itamarandiba, haveria melhora significativa na qualidade da água, fazendo com que 100% do rio Araçuaí entrasse em conformidade com a legislação. Logo, a análise possibilitou avaliar que as ações de melhoria do saneamento básico devem ser direcionadas para o município de Itamarandiba.
The Relationship between Reflective Disposition and Persistence in Education
Authors: Robinson Peter 
Published: June 2022

Getting students to engage in reflective thought is a «wicked» problem in teaching. Students may demonstrate a resistance to any form of reflection, analysis or critical thought and instead automatically default to surface approaches which are non-productive in academic contexts. This resistance may involve an aversion which leads to students not persisting to higher levels of education and dropping out. The present study investigates the relationship between the resistance to reflective processing and persistence in education using the Cognitive Reflection Test (CRT) and some additional survey items aimed at testing surface processing tendencies in non-academic contexts. It provides support for the hypothesis that a general aversion to reflective processing appears to inhibit academic progression and correlates with drop-out from courses midstream. It closes by suggesting that aversion to analytical thinking may be a threshold issue that needs to be addressed separately before students can progress to any challenging content.
Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex
Authors: Passer Andrew Ryan , Clancey Shelly Applen , Shea Terrance , David-Palma Márcia , Averette Anna Floyd , Boekhout Teun , Porcel Betina M , Nowrousian Minou , Cuomo Christina A , Sun Sheng , Heitman Joseph , Coelho Marco A 
Published: June 2022

eLife digestFungi are enigmatic organisms that flourish in soil, on decaying plants, or during infection of animals or plants. Growing in myriad forms, from single-celled yeast to multicellular molds and mushrooms, fungi have also evolved a variety of strategies to reproduce. Normally, fungi reproduce in one of two ways: either they reproduce asexually, with one individual producing a new individual identical to itself, or they reproduce sexually, with two individuals of different ‘mating types’ contributing to produce a new individual. However, individuals of some species exhibit ‘homothallism’ or self-fertility: these individuals can produce reproductive cells that are universally compatible, and therefore can reproduce sexually with themselves or with any other cell in the population.Homothallism has evolved multiple times throughout the fungal kingdom, suggesting it confers advantage when population numbers are low or mates are hard to find. Yet some homothallic fungi been overlooked compared to heterothallic species, whose mating types have been well characterised. Understanding the genetic basis of homothallism and how it evolved in different species can provide insights into pathogenic species that cause fungal disease.With that in mind, Passer, Clancey et al. explored the genetic basis of homothallism in Cryptococcus depauperatus, a close relative of C. neoformans, a species that causes fungal infections in humans. A combination of genetic sequencing techniques and experiments were applied to analyse, compare, and manipulate C. depauperatus’ genome to see how this species evolved self-fertility.Passer, Clancey et al. showed that C. depauperatus evolved the ability to reproduce sexually by itself via a unique evolutionary pathway. The result is a form of homothallism never reported in fungi before. C. depauperatus lost some of the genes that control mating in other species of fungi, and acquired genes from the opposing mating types of a heterothallic ancestor to become self-fertile.Passer, Clancey et al. also found that, unlike other Cryptococcus species that switch between asexual and sexual reproduction, C. depauperatus grows only as long, branching filaments called hyphae, a sexual form. The species reproduces sexually with itself throughout its life cycle and is unable to produce a yeast (asexual) form, in contrast to other closely related species.This work offers new insights into how different modes of sexual reproduction have evolved in fungi. It also provides another interesting case of how genome plasticity and evolutionary pressures can produce similar outcomes, homothallism, via different evolutionary paths. Lastly, assembling the complete genome of C. depauperatus will foster comparative studies between pathogenic and non-pathogenic Cryptococcus species.
The Effect of Company Size, Dividend Policy and Profitability on Company Value: Comparative Analysis before and during the Coronavirus Disease-19 Pandemic
Authors: Sari Sinta Mayang , Septiyanti Ratna , Komaruddin . 
Published: June 2022

Aims: This study aims to provide empirical proof of the effect of firm size, dividend policy, and profitability on the company value before and during the Covid-19 pandemic.
Study Design: This study used a quantitative descriptive method.
Place and Duration of Study: Indonesia Stock Exchange, Period 2016-2020.
Methodology: This study used quantitative data with secondary data the in form of annual financial reports. The population is manufacturing companies in the consumer goods industry sector listed on the Indonesia Stock Exchange in 2016 - 2020, with a sample of 31 companies. Data analysis in this study was performed using multiple linear regression using IBM SPSS.
Result: The results show that there was no effect and no significant of dividend policy on company value before the Covid-19 pandemic. While company size and profitability were effect and significant on company value before the Covid-19 pandemic. This is different during the covid-19 pandemic, company size was no effect and no significant on company value during the Covid-19 pandemic. While dividend policy and profitability were effect and significant to company value during the Covid-19 pandemic.
Conclusion: This study shows that there are significant differences in the effect of company size, dividend policy, and profitability on company value before and during the Covid-19 pandemic.
Hybrid Lithium‐Ion/Metal Electrodes Enable Long Cycle Stability and High Energy Density of Flexible Batteries
Authors: Xie Chuan , Chang Jian , Shang Jian , Wang Lei , Gao Yuan , Huang Qiyao , Zheng Zijian 
Published: June 2022

AbstractHigh‐energy, stable, and flexible lithium batteries are highly demanded for next‐generation flexible and wearable electronics. Although the cycling stability of flexible lithium‐ion batteries (LIBs) is high, their energy density reaches the bottleneck because of the use of graphite anode. On the other hand, flexible lithium‐metal batteries provide higher energy density because of the use of lithium (Li) metal anode, but the cycling stability is poor. Herein, a new type of flexible hybrid lithium‐ion/metal battery (f‐LIMB) is reported, which simultaneously possesses enhanced energy density, stable cycling behavior, and outstanding flexibility. f‐LIMB is enabled by using the prelithiated carbon cloth as the anode, which improves the initial Coulombic efficiency by a prior formation of solid electrolyte interface, benefits the subsequent deposition of Li metal due to the preformed lithiophilic LixC6 compounds, and enhances the cycle life and energy density of batteries through a Li compensation mechanism. The f‐LIMB full cell possesses an improved gravimetric and volumetric energy density by as much as 64% and 67%, in comparison to the flexible LIB counterpart, and pertains high capacity retention of 84% after 1000 charge/discharge cycles. In addition, the f‐LIMB can be readily bent down to a small radius of 2.5 mm.
A Multimodal Therapeutic Nanoplatform Overcoming Tumor Hypoxia Heterogeneity for Improved Tumor Chemoradiotherapy
Authors: Zhang Lanqiong , Du Xiaomeng , Li Qian , Qian Lili , Chen Jiawei , Liu Chaoyong , Yu Qingsong , Gan Zhihua 
Published: June 2022

AbstractThe hypoxic nature of solid tumors limits the efficacy of radiotherapy (RT) and leads to radiation resistance. Hypoxic radiosensitizers can enhance tumor radiosensitivity by mimicking the effects of oxygen, but their efficacy has been limited by the heterogeneous oxygen distribution in tumor tissue. Herein, a multimodal therapeutic nanoplatform fabricated by co‐encapsulation of chlorin e6 and tirapazamine (TPZ) with an amphiphilic polymeric conjugate of cisplatin (CDDP) and metronidazole is reported. This platform could kill the tumor periphery cells by the deeply penetrated oxygen‐consuming sonodynamic therapy and unify the heterogeneously hypoxic context simultaneously, which then actuate the release and activation of the loaded TPZ. TPZ could further sensitize RT along with CDDP and metronidazole residues under the resultant hypoxic condition, which significantly decreases the radiation dosage required to cause massive cell damage. Except for the significantly suppressed tumor growth and metastasis caused by the multimodal therapeutic nanoplatform, its hypoxia‐directed feature also endows it with excellent safety.
Mechanochemically Induced Cross Dehydrogenative Coupling Reactions under Ball Milling
Authors: Egorov Ilya N. , Mukherjee Anindita , Santra Sougata , Kopchuk Dmitry S. , Kovalev Igor S. , Liu Yuanli , Zyryanov Grigory V. , Majee Adinath , Chupakhin Oleg N. , Ranu Brindaban C. 
Published: June 2022

AbstractCross dehydrogenative coupling (CDC) reactions have become a convenient synthetic strategy for the synthesis of various (het)aromatic scaffolds. In recent times ball milling has emerged as a powerful tool to perform reactions in a greener way. The current review highlights various applications of cross dehydrogenative coupling reactions under ball milling towards synthesis of useful molecules in a more efficient and convenient manner.magnified image
In Situ Structural Reconstruction to Generate the Active Sites for CO2 Electroreduction on Bismuth Ultrathin Nanosheets
Authors: Yuan Yuliang , Wang Qiyou , Qiao Yan , Chen Xuli , Yang Zhilong , Lai Wenchuan , Chen Tianwei , Zhang Guanhua , Duan Huigao , Liu Min , Huang Hongwen 
Published: June 2022

AbstractElectrochemical structural reconstruction of catalysts may generate real active sites that differ from the initial catalyst, but is often ignored. Herein, combining in situ and ex situ techniques, it is identified that the bismuth nanosheets (NS) dotted with large numbers of coordinatively unsaturated pit sites is produced via the in situ structural reconstruction of Bi(OH)3 NS. Such reconstructed Bi NS shows greatly improved catalytic activity toward CO2 electroreduction, with a 2.6‐fold increase in current density compared with intact Bi NS, high Faradaic efficiency for HCOO− production (>95%), and an extraordinary turnover frequency of 0.35 s−1 at −0.98 VRHE. In addition, it delivers industrial‐relevant current density of 325 mA cm−2 without compromising selectivity in a flow cell. The mechanistic studies demonstrate that these coordinatively unsaturated sites acting as the real active sites favor the stabilization of key intermediate *OCHO, which thus facilitate the reaction kinetics for HCOO− production. This work not only provides a unique perspective on the construction of efficient catalysts for CO2 electroreduction, but also implies the importance in recognition of structural reconstruction.