bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence-based classification of bone tumors in the proximal femur on plain radiographs: System development and validation
Authors: Park Chan-Woo , Oh Seong-Je , Kim Kyung-Su , Jang Min-Chang , Kim Il Su , Lee Young-Keun , Chung Myung Jin , Cho Baek Hwan , Seo Sung-Wook 
Published: February 2022

Purpose
Early detection and classification of bone tumors in the proximal femur is crucial for their successful treatment. This study aimed to develop an artificial intelligence (AI) model to classify bone tumors in the proximal femur on plain radiographs.

Methods
Standard anteroposterior hip radiographs were obtained from a single tertiary referral center. A total of 538 femoral images were set for the AI model training, including 94 with malignant, 120 with benign, and 324 without tumors. The image data were pre-processed to be optimized for training of the deep learning model. The state-of-the-art convolutional neural network (CNN) algorithms were applied to pre-processed images to perform three-label classification (benign, malignant, or no tumor) on each femur. The performance of the CNN model was verified using fivefold cross-validation and was compared against that of four human doctors.

Results
The area under the receiver operating characteristic (AUROC) of the best performing CNN model for the three-label classification was 0.953 (95% confidence interval, 0.926–0.980). The diagnostic accuracy of the model (0.853) was significantly higher than that of the four doctors (0.794) (P = 0.001) and also that of each doctor individually (0.811, 0.796, 0.757, and 0.814, respectively) (P<0.05). The mean sensitivity, specificity, precision, and F1 score of the CNN models were 0.822, 0.912, 0.829, and 0.822, respectively, whereas the mean values of four doctors were 0.751, 0.889, 0.762, and 0.797, respectively.

Conclusions
The AI-based model demonstrated high performance in classifying the presence of bone tumors in the proximal femur on plain radiographs. Our findings suggest that AI-based technology can potentially reduce the misdiagnosis of doctors who are not specialists in musculoskeletal oncology.
A meta-analysis of safety and efficacy of endovascular aneurysm repair in aneurysm patients with severe angulated infrarenal neck
Authors: Bernardini Giulia , Litterscheid Sarah , Torsello Giovanni Battista , Torsello Giovanni Federico , Beropoulis Efthymios , Özdemir-van Brunschot Denise 
Published: February 2022

Objectives
A growing number of abdominal aortic aneurysms with severe angulated neck anatomy is treated by endovascular means. However, contradictory early and late outcomes have been reported. Our review and outcome analysis attempted to evaluate the available literature and provide clinicians with a base for clinical implementation and future research.

Materials and methods
A systematic review of the literature was undertaken to identify the outcomes of endovascular aneurysm repair in patients with severe infrarenal neck angulation (SNA ≥ 60°) vs non-severe neck angulation (NSNA). Outcome measures included perioperative complications, type 1a endoleak, neck-related secondary procedures, stent graft migration, aneurysm rupture, increase (>5mm) in sac diameter, all-cause and aneurysm-related mortality (PROSPERO Nr.: CRD42021233253).

Results
Six observational studies reporting on 5981 patients (1457 with SNA and 4524 with NSNA) with a weighted mean follow-up period of 1.8 years were included. EVAR in SNA compared with NSNA was associated with a higher rate of type 1a endoleak at 30 days (4.0% vs 1.8%; p< 0.00001), at 1 year (2.8% vs 1.9%; p<0.03), at 2 years (4.9% vs 2.1%; p< 0.0002), at 3 years (5.6% vs 2.6%; p< 0.0001). The rate of neck-related secondary procedures was significantly higher at 1 year (6.6% vs 3.9%; p<0.05) and at 3 years (13.1% vs 9%; p<0.05). Graft migration, aneurysm sack increase, aneurysm rupture and all-cause mortality were not statistically different at mid-term.

Conclusions
The use of EVAR in severely angulated infrarenal aortic necks is associated with a high rate of early and mid-term complications. However, aortic related and all-causes mortality are not higher compared to patients with NSNA. Therefore, EVAR should be cautiously used in patients with SNA.
Factors influencing COVID-19 vaccine uptake among adults in Nigeria
Authors: Adedeji-Adenola Halimat , Olugbake Olubusola A. , Adeosun Shakirat A. 
Published: February 2022

Background
Emerging variants of Coronavirus disease 2019 (COVID-19) has claimed over 3000 lives in Nigeria and vaccination remains a means of reducing the death toll. Despite ongoing efforts by the government to ensure COVID-19 vaccination of most residents to attain herd immunity, myths and beliefs have adversely shaped the perception of most Nigerians, challenging the uptake of COVID-19 vaccine. This study aimed to assess the factors influencing the awareness, perception, and willingness to receive COVID-19 vaccine among Nigerian adults.

Methods
A cross-sectional online nationwide study was conducted from April to June 2021 among Nigerian adult population using the snowballing method. Descriptive analysis was used to summarise the data. Univariate and multivariate analysis was used to identify the predictors of COVID-19 uptake among the respondents. A p value <0.05 was considered significant.

Results
A total of 1058 completed forms were analysed and 63.9% were females. The mean age was 40.8 years±12.2 years. Most of the respondents (740; 69.5%) had satisfactory awareness of the vaccination exercise. The media was the main source of information. Health workers reported higher level of awareness (aOR = 1.822, 95% CI: 1.388–2.524, p<0.001). Respondents that are Christians and Muslims had better awareness compared to the unaffiliated (aOR = 6.398, 95% CI: 1.918–21.338, P = 0.003) and (aOR = 7.595, 95% CI: 2.280–25.301, p<0.001) respectively. There is average score for perception statements (566; 53.2%) towards COVID-19 vaccination. Close to half of the respondents (44.2%) found the short period of COVID-19 production worrisome. Majority of the respondents were willing to get the vaccine (856; 80.9%). Those without a prior diagnosis of COVID-19 had a lower willingness to get vaccinated (aOR = 0.210 (95% CI: 0.082–0.536) P = 0.001).

Conclusion
The study revealed a high level of awareness, willingness to receive the vaccine and moderate perception towards the vaccination activities. Influencing factors that significantly affects awareness were religion, occupation, education and prior diagnosis of COVID-19; for perception and willingness—occupation, and prior diagnosis of the COVID-19 were influencing factors.
Major ambulatory surgery among US adults with inflammatory bowel disease, 2017
Authors: Xu Fang , Wheaton Anne G. , Liu Yong , Greenlund Kurt J. 
Published: February 2022

BackgroundPatients with inflammatory bowel disease (IBD) have higher health services use than those without IBD. We investigated patient and hospital characteristics of major ambulatory surgery encounters for Crohn’s disease (CD) or ulcerative colitis (UC) vs non-IBD patients.MethodsWe conducted a cross-sectional study using 2017 Nationwide Ambulatory Surgery Sample.Major ambulatory surgery encounters among patients aged ≥18 years with CD (n = 20,635) or UC (n = 9,894) were compared to 9.4 million encounters among non-IBD patients. Weighted percentages of patient characteristics (age, sex, median household income, primary payers, patient location, selected comorbidities, discharge destination, type of surgeries) and hospital-related characteristics (hospital size, ownership, location and teaching status, region) were compared by IBD status (CD, UC, and no IBD). Linear regression was used to estimate mean total charges, controlling for these characteristics.ResultsCompared with non-IBD patients, IBD patients were more likely to have private insurance, reside in urban areas and higher income zip codes, and undergo surgeries in hospitals that were private not-for-profit, urban teaching, and in the Northeast. Gastrointestinal surgeries were more common among IBD patients. Some comorbidities associated with increased risk of surgical complications were more prevalent among IBD patients. Total charges were 9% lower for CD patients aged <65 years (Median: $16,462 vs $18,106) and 6% higher for UC patients aged ≥65 years (Median: $16,909 vs $15,218) compared to their non-IBD patient counterparts.ConclusionsDifferences in characteristics of major ambulatory surgery encounters by IBD status may identify opportunities for efficient resource allocation and positive surgical outcomes among IBD patients.
PENTINGNYA IDEOLOGI PANCASILA DALAM MENGHADAPI BERITA YANG TERSEBAR DI MASA PANDEMI COVID-19
Authors: Aeni Zakia Nurul , Nugraha Dadi Mulyadi , . Supriyono 
Published: February 2022

Ideology is knowledge or values, which are generically the basis for a person or citizens to know and choose the basic behavior of the understanding that is believed. Pancasila is the basis of the state and the view of life of the Indonesian people, in everyday life both in the community. This ideological attitude is very important to be implanted and implemented, because the Pancasila ideology contains rules that apply as a guide in dealing with and solving various problems. As a form of implementation of Pancasila's ideological attitude in dealing with news in the era of the Covid-19 pandemic, namely being critical in receiving news, seeking data or truth, by filtering first.
Ideologi merupakan pengetahuan atau nilai-nilai, yang secara generik sebagai landasan bagi seorang atau pula warga dapat mengetahui dan memilih perilaku dasar dari pemahaman yang diyakini. Pancasila merupakan dasar negara dan pandangan hidup bangsa Indonesia, dalam kehidupan sehari-hari baik di lingkungan masyarakat. Sikap ideologi itu sangat penting untuk ditanamkan dan diimplementasikan, karena ideologi pancasila memuat aturan-aturan yang berlakaku sebagai petunjuk dalam menghadapi dan menyelesaikan berbagai permasalahan. Sebagai salah satu bentuk implementasi sikap ideologi pancasila dalam menghadapi berita di era pandemi Covid-19 yaitu bersikap kritis dalam menerima berita, mencari data atau kebenaran, dengan memfilter terlebih dahulu.
Acromegaly caused by a GHRH-producing pancreatic neuroendocrine tumor: a rare manifestation of MEN1 syndrome
Authors: Koivikko Minna , Ebeling Tapani , Mäkinen Markus , Leppäluoto Juhani , Raappana Antti , Ahtiainen Petteri , Salmela Pasi 
Published: February 2022

Summary
Multiple endocrine neoplasia type 1 NM_001370259.2(MEN1):c.466G>C(p.Gly156Arg) is characterized by tumors of various endocrine organs. We report on a rare, growth hormone-releasing hormone (GHRH)-releasing pancreatic tumor in a MEN1 patient with a long-term follow-up after surgery. A 22-year-old male with MEN1 syndrome, primary hyperparathyroidism and an acromegalic habitus was observed to have a pancreatic tumor on abdominal CT scanning, growth hormone (GH) and insulin-like growth factor 1 (IGF1) were elevated and plasma GHRH was exceptionally high. GHRH and GH were measured before the treatment and were followed during the study. During octreotide treatment, IGF1 normalized and the GH curve was near normal. After surgical treatment of primary hyperparathyroidism, a pancreatic tail tumor was enucleated. The tumor cells were positive for GHRH antibody staining. After the operation, acromegaly was cured as judged by laboratory tests. No reactivation of acromegaly has been seen during a 20-year follow-up. In conclusion, an ectopic GHRH-producing, pancreatic endocrine neoplasia may represent a rare manifestation of MEN1 syndrome.

Learning points

Clinical suspicion is in a key position in detecting acromegaly.

Remember genetic disorders with young individuals having primary hyperparathyroidism.

Consider multiple endocrine neoplasia type 1 syndrome when a person has several endocrine neoplasia.

Acromegaly may be of ectopic origin with patients showing no abnormalities in radiological imaging of the pituitary gland.
PENINGKATAN PENGELOLAAN KEUANGAN BERBASIS EXCEL PADA BADAN USAHA MILIK DESA
Authors: Animah  , Widia Astuti  , Robith  
Published: February 2022

Desa Giri Sasak merupakan salah satu desa pemekaran baru yang mayoritas masyarakatnya adalah petani, oleh karena itu pola belanja masyarakatnya adalah pada saaat panen mereka akan belanja lebih banyak terkait dengan kebutuhan pokok, sedangkan kebutuhan harian hampir dikatakan tidak ada pengeluaran. Namun ketika terdapat pengeluaran yang tidak rutin, seperti pernikahan, kematian, dan khitanan maka mereka cenderung berhutang ke rentenir. Akan tetapi hal ini tidak memberikan dampak yang lebih baik bagi masyarakat. Dengan demikian, keberadaan BUMDes ini sangat membantu memenuhi kebutuhan masyarakat. Berdasarkan observasi, pengelola BUMDes belum memahami dengan benar bagaimana pengelolaan keuangan yang baik. Untuk meningkatkan pengelolaan keuangan BUMDes Desa Giri Sasak, TIM pengabdian melakukan pelatihan dan penampingan kepada BUMDes desa Giri Sasak terkait bagaimana penegelolaaan kauangan dengan sistem informasi berbasis excel.
DIVERSIFIKASI PRODUK DAN PERHITUNGAN HARGA POKOK PRODUKSI KOPI
Authors: Sulaiman Sarmo  , Sri Darwini  , Imanuella Romaputri Andilolo  
Published: February 2022

Usaha kopi ini berlokasi di Pagutan Permai dan didirikan sejak tahun 2015. Pengelola kopi selam ini hanya memproduksi kopi yang natural sajadan menghitung biaya produksi berdasarkan pada biaya yang mengeluarkan uang saja, selain itu memasarkan dengan kemasan yang kurang menarik dan jaringan pemsaran lebih kepada keluarga terdekat saja. Oleh karena itu kami sebagai tim pengabdian perlu melakukan pendampingan penyuluhan dan pelatihan diversifikasi produk dan perhitungan harga pokok produksi serta cara memasarkan dengan menggunakan teknologi dan merancang kemasan yang menarik buat pelanggan. Pelatihan ini akan dilaksanakan selama 4 bulan dengan cara memberikan penyuluhan dan pelatihan serta mengidentifikasi persoalan, sedangkan dalam perhitungan harga pokok menggunakan pendekatan fullcost, dan model pemasaran menggunakan instagram. Hasil pengabdian para pelaku usaha kopi sangat merespon kegiatan ini, dan mencoba membuat diversifikasi produk kopi jahe dan kopi kedele, serta membuat brand produk kopi dengan nama KOHEJA, dan memasarkan lewat instagram.
EDUCATION ON HANDLING GREEN TURTLE (Chelonia mydas) INJURED DUE TO ILLEGAL ARREST OF COMMUNITY PERSONS IN SUPRAU VILLAGE
Authors: Sayuti Mohammad , Widasari Ferliana , Junaidi Ahmad , Setia Abadi Agung , Sofian Achmad 
Published: February 2022

The number of turtle populations from year to year has decreased. One of the causes is the arrests made by the community for consumption purposes. On April 29, 2021, a green turtle was eaten by the Directorate of Polair, Sorong City, with an injured condition that will be used as food for consumption. The purpose of this activity is to educate the public on the handling of injured turtles and socialize related to turtle conservation. The method of turtle handling activities is direct daily care with medication and turtle feeding programs, while socialization activities are carried out with mini workshops attended by representatives of the Marine and Fisheries Resources Supervisor, Sorong Marine and Fisheries Polytechnic, Directorate of Polair Sorong City, West Papua Natural Resources Conservation Center, Sorong District Court, Sailing Science Education and Training Center, Sorong City Fisheries Service, Papua Turtle Foundation, Conservation International (CI) and Nusantara Nature Conservation Foundation and public figure. The results of the activities for handling injured turtles, healthy turtles returned with dry wounds so that the turtles could be released into the wild. The socialization activity went smoothly with increasing understanding regarding the importance of turtle conservation by the community by signing a Memorandum of Understanding related to turtle conservation.
Hubungan Panjang Bobot dan Beberapa Aspek Reproduksi Ikan Tongkol Lisong (Auxis rochei Risso, 1810) di Perairan Teluk Bone
Authors: Syainullah Wahana  , Yusnan Suyuti DM  , Muhammad Nur  , Adiara Firdhita Alam Nasyrah  
Published: February 2022

Penelitian ini bertujuan menganalisis aspek hubungan panjang bobot dan beberapa aspek reproduksi ikan tongkol lisong sehingga dapat menjadi dasar dalam pengambilan kebijakan di perairan Teluk Bone. Pengambilan sampel dilakukan di Kelurahan Lonrae, Kabupaten Bone, pada bulan September hingga November 2021 Tipe pertumbuhan diketahui dengan melakukan analisis hubungan panjang bobot, TKG diketahui dengan cara analisis morfologi, IKG dihitung berdasarkan metode Johnson. Hasil analisis hubungan panjang bobot diperoleh koefisien regresi masing-masing b = 3.3345 pada bulan September dan b = 2,837 pada bulan Oktober dan b = 3,3690 pada bulan November. Hasil uji t diperoleh t hitung > t tabel sehingga digolongan ikan tongkol pada bulan September dan November ke dalam pola pertumbuhan allometrik positif dan pada bulan Oktober ke dalam pola pertumbuhan allometrik negatif. Faktor kondisi tongkol lisong di Perairan Teluk Bone diperoleh kisaran 0,95-1,03 dengan rata-rata 0,97, pada jantan 1,23-1,44 dengan rata-rata 1,33 dan pada betina diperoleh kisaran 0,72-0,83 dengan rata-rata 0,77. Nilai IKG yang berkisar antara 0,053 – 0,242 pada ikan jantan 0,052 – 0,068 pada ikan betina. Ikan tongkol yang ditemukan dikategorikan belum matang gonad.
The Growth of Chlorella sp. With Varying Nutrient Concentration
Authors: Hismayasari Intanurfemi , Ernawati Ernawati , Agung Setia Abadi  , Asthervina Widyastami Puspitasari  
Published: February 2022

The aim of this study was to determine the effect of differences addition of culture medium concentrations on the growth of microalgae type Chlorella sp. Samples were obtained from the Center for Brackish Water Cultivation Fisheries (BBPBAP), Jepara. This research was conducted at the Laboratory of Nutrition and Natural Feed Sorong Marine and Fisheries Polytechnic with an experimental method using four treatments with addition of walne medium, there were A (adding only at the beginning of cultivation); treatment B (adding every day); C (adding every two days), and treatment; D (adding every three days). The cell growth performance was significantly found in treatment C with the addition of nutrients every two days with a peak cell density of Chlorella sp was 2,628,450 cells / ml. There is a need for mass culture assay to determine the level of effectiveness and efficiency.
Kualitas Gel Surimi dari Limbah Tetelan Trimming Ikan Tuna (Thunnus sp.) dan Ikan Kakap (Lates Calcarifer) dengan Penambahan Tepung Porang
Authors: Kasim Muh. , Nurlaeli Fattah  , Rahmatang Rahmatang 
Published: February 2022

Penelitian ini bertujuan untuk memperoleh formulasi penambahan tepung porang yang terbaik dan nilai mutu yang baik dalam meningkatkan kualitas gel surimi .Perlakuan penelitian dengan penambahan tepung porang 1%, 2%, 5%, 10% dan 15 %. Penelititan ini dilakuan secara eksperimental dengan lima perlakuan, tiga ulangan dan dianalisis dengan statistik ANOVA. Parameter yang diamati adalah kekuatan gel, pH, kadar air, uji gigit dan uji lipat. Hasil uji kualitas gel surimi untuk ikan tuna : nilai kekuatan gel berkisar 1625.15±1.67 - 2818.99±3.63 g.cm, pH 5.9-6.4, kadar air 67.1%-74.5%, uji gigit 2.9-7.3 cm, uji lipat 2.4-4.5. Untuk ikan kakap : nilai kekuatan gel berkisar 791.35±2.43 - 1622.39±1.16 g.cm, pH 5.9-6.4, kadar air 69.8- 76.5, uji gigit 7.2-8.7, uji lipat 3.4-4.6. Kesimpulan penelitian menunjukkan bahwa penambahan tepung porang 1%, 2%, 5%, 10% dan 15 % dapat meningkatkan kekuatan gel hingga >500 g.cm. Namun, penambahan diatas 1% memberikan warna gelap pada surimi sehingga, penambahan maksimal tepung porang tidak disarankan lebih dari 1%.
PEMBELAJARAN PEMBANGUNAN PULAU TERLUAR BERBASIS SEKTOR KELAUTAN DAN PERIKANAN: STUDI KASUS SKPT BIAK NUMFOR
Authors: Ramadhan Andrian , Muhartono Rizky , Kurniawan Tikkyrino , Hadiastuty Harnita 
Published: February 2022

Konsep Sentra Kelautan Perikanan Terpadu (SKPT) merupakan tindak lanjut dari nawacita, yang memprioritaskan pembangunan kelautan dan perikanan di kawasan pulau-pulau kecil dan perbatasan/pinggiran. Tantangan utama terkait upaya pembangunan daerah pinggiran adalah ketergantungannya pada intervensi kebijakan yang datang dari luar yang merupakan aspek sumberdaya manusia dan kinerja kelembagaan. Hal tersebut dikhawatirkan berimplikasi negatif pada aspek distribusi manfaat pembangunan dan kepentingan masyarakat lokal. Terkait itu, makalah ini bertujuan untuk mengungkapkinerja pembangunan sumberdaya manusia dan kelembagaan serta isu pembangunan inklusif pada program SKPT. Penelitian dilakukan pada Desember tahun 2019 menggunakan pendekatan kualitatif dan studi kasus, yang dimaksudkan untuk mengeksplorasi konsep dan pelaksanaan program SKPT dalam perspektif pembangunan sumberdaya manusia, kelembagaan dan isu pembangunan inklusif. Hasil penelitian menunjukkan bahwa pembangunan eksogenus tidak harus berkonotasi pembangunan yang mengabaikan aspek manusia dan kinerja kelembagaan lokal. Pelajaran dari Program SKPT di Kabupaten Biak Numfor menunjukkan bahwa dua isu tersebut dapat menjadi modal penting yang ikut berkontribusi pada keberhasilan intervensi terkait program SKPT, termasuk berbagai aktivitas pemberian bantuan dan ekspansi pasar yang terkoneksi dengan kelembagaan-kelembagaan lokal. Title: Lesson Learned of The Outer Island Development Based on The Marine and Fishery Sector: A Case Study of The SKPT of Biak NumforThe concept of Integrated Marine and Fisheries Center (SKPT) is derived from the Nawacita that prioritizes the development of small islands and border areas. The major challenge of border area is the dependence on external policy regardless to its local human resource and institutional development. As the result, the development might cause benefits distribution issue and leave localcommunities behind. This paper aims to reveal the extent of human and institutional development, as well as the issue of inclusive development in the SKPT program. The research was conducted in December 2019, using a qualitative approach (case study) to explore the concept and implementation of the SKPT that is related to human resource development, institutions and inclusive development issues. The results show that exogenous development must not ignore the issue of local human resource and institutional development. In fact, the SKPT in Biak Numfor Regency uses these two issues as the basis for determining the programs such as forms of aids and market expansion strategies that connect to local institutions.