bluuebunny/crossref_metadata_2025_split huggingface dataset:
International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence
Authors: Wickstrom Ronny , Taraschenko Olga , Dilena Robertino , Payne Eric T. , Specchio Nicola , Nabbout Rima , Koh Sookyong , Gaspard Nicolas , Hirsch Lawrence J. ,   the International NORSE Consensus Group
Published: August 2022

AbstractObjectiveThis study was undertaken to develop consensus‐based recommendations for the management of adult and pediatric patients with new onset refractory status epilepticus (NORSE)/febrile infection‐related epilepsy syndrome (FIRES) based on best evidence and experience.MethodsThe Delphi methodology was followed. A facilitator group of nine experts was established, who defined the scope, users, and suggestions for recommendations. Following a review of the current literature, recommendation statements concerning diagnosis, treatment, and research directions were generated, which were then rated on a scale of 1 (strongly disagree) to 9 (strongly agree) by a panel of 48 experts in the field. Consensus that a statement was appropriate was reached if the median score was ≥7 and inappropriate if the median score was ≤3. The analysis of evidence was mapped to the results of each statement included in the Delphi survey.ResultsOverall, 85 recommendation statements achieved consensus. The recommendations are divided into five sections: (1) disease characteristics; (2) diagnostic testing and sampling; (3) acute treatment; (4) treatment in the postacute phase; and (5) research, registries, and future directions in NORSE/FIRES. The detailed results and discussion of all 85 statements are outlined herein. A corresponding summary of findings and practical flowsheets are presented in a companion article.SignificanceThis detailed analysis offers insight into the supporting evidence and the current gaps in the literature that are associated with expert consensus statements related to NORSE/FIRES. The recommendations generated by this consensus can be used as a guide for the diagnosis, evaluation, and management of patients with NORSE/FIRES, and for planning of future research.
Large‐scale reforestation can increase water yield and reduce drought risk for water‐insecure regions in the Asia‐Pacific
Authors: Teo Hoong Chen , Raghavan Srivatsan V. , He Xiaogang , Zeng Zhenzhong , Cheng Yanyan , Luo Xiangzhong , Lechner Alex M. , Ashfold Matthew J. , Lamba Aakash , Sreekar Rachakonda , Zheng Qiming , Chen Anping , Koh Lian Pin 
Published: August 2022

AbstractLarge‐scale reforestation can potentially bring both benefits and risks to the water cycle, which needs to be better quantified under future climates to inform reforestation decisions. We identified 477 water‐insecure basins worldwide accounting for 44.6% (380.2 Mha) of the global reforestation potential. As many of these basins are in the Asia‐Pacific, we used regional coupled land‐climate modeling for the period 2041–2070 to reveal that reforestation increases evapotranspiration and precipitation for most water‐insecure regions over the Asia‐Pacific. This resulted in a statistically significant increase in water yield (p < .05) for the Loess Plateau–North China Plain, Yangtze Plain, Southeast China, and Irrawaddy regions. Precipitation feedback was influenced by the degree of initial moisture limitation affecting soil moisture response and thus evapotranspiration, as well as precipitation advection from other reforested regions and moisture transport away from the local region. Reforestation also reduces the probability of extremely dry months in most of the water‐insecure regions. However, some regions experience nonsignificant declines in net water yield due to heightened evapotranspiration outstripping increases in precipitation, or declines in soil moisture and advected precipitation.
Optimizing the management of analytical interferences affecting red blood cells on XN‐10 (Sysmex®)
Authors: Henry Sylvain , Gérard Delphine , Salignac Sylvain , Perrin Julien 
Published: August 2022

AbstractIntroductionInterferences on red blood cells (RBCs) measurement and the associated parameters in haematology analyzers are very common. Many sources of interferences are described but their management remains uncertain depending on the measurement system; we aimed at developing an optimized scheme allowing the accurate management of most interferences affecting RBCs, based on the alternative “optical” parameters from SYSMEX XN‐10.MethodsSamples from 12 groups of relevant interferences were analysed and compared with a control group allowing (1) the determination of deviation thresholds beyond which an interference is likely, and (2) the development of two flowcharts for their subsequent management. These flowcharts were then evaluated among a bank of retrospective typical cases of interferences and in the routine flow of the laboratory.ResultsAfter verifying the excellent agreement between standard and alternative parameters, the comparative study between analytical channels allowed to determine an acceptable deviation and then discriminate technical concerns caused by cold agglutinins, leukocytosis and plasma‐related interferences. This led to the development of flowcharts ensuring the accurate management of these interferences, whether MCHC is <320 or >365 g/L. These proposed flowcharts allowed the correction of 63/65 historical confirmed interferences cases (97%). Furthermore, they corrected 18 results among 901 unselected prospective samples.ConclusionThe resulting flowcharts allow a relevant correction for most common interferences affecting RBCs and are now definitively included in the routine analytical management and will be directly incorporated in the middleware of the laboratory.
An improved algorithm to harmonize child overweight and obesity prevalence rates
Authors: Cole Tim J. , Lobstein Tim 
Published: August 2022

SummaryBackgroundPrevalence rates of child overweight and obesity for a group of children vary depending on the BMI reference and cut‐off used. Previously we developed an algorithm to convert prevalence rates based on one reference to those based on another.ObjectiveTo improve the algorithm by combining information on overweight and obesity prevalence.MethodsThe original algorithm assumed that prevalence according to two different cut‐offs A and B differed by a constant amount on the z‐score scale. However the results showed that the z‐score difference tended to be greater in the upper tail of the distribution and was better represented by , where was a constant that varied by group. The improved algorithm uses paired prevalence rates of overweight and obesity to estimate for each group. Prevalence based on cut‐off A is then transformed to a z‐score, adjusted up or down according to and back‐transformed, and this predicts prevalence based on cut‐off B. The algorithm's performance was tested on 228 groups of children aged 6–17 years from 20 countries.ResultsThe revised algorithm performed much better than the original. The standard deviation (SD) of residuals, the difference between observed and predicted prevalence, was 0.8% (n = 2320 comparisons), while the SD of the difference between pairs of the original prevalence rates was 4.3%, meaning that the algorithm explained 96.7% of the baseline variance (88.2% with original algorithm).ConclusionsThe improved algorithm appears to be effective at harmonizing prevalence rates of child overweight and obesity based on different references.
John Calvin's Apoiconic Vision of the Body and the Blood
Authors: Capps Franklin Tanner 
Published: August 2022

AbstractThis article offers a reading of a feature of John Calvin's theology that has received little attention – the role of visuality in his writings on the sacraments as developed between the years of 1536 and 1561. As an intervention into longstanding debates over the legacy of his sacramental theology, I argue that Calvin's use of visual categories to describe the sacramental event is best understood in terms of what I will call the ‘apoiconic’: a vision of divinity had through visual negation. I suggest that for Calvin the sacramental elements signal a divine absence that, in turn, redirects the gaze upward to Christ, whose spiritual presence constitutes the sacraments' substance. To make this argument, I trace the trinitarian dynamics of this ‘apoiconic vision’, where the Spirit unveils the living Christ by illumining the eyes of faith to comprehend the power of God that dwells therein. I close by reflecting on ‘apoiconicity’ as a strategy for moving beyond anxieties over materiality's idolatrous entanglements and for developing a sacramental theology that is cosmic in scope.
Crystallization‐induced suppression of intumescence in aqueous alkali silicates
Authors: Mohsin Hamza , Burov Ekaterina , Tusseau‐Nenez Sandrine , Maron Sébastien , Devys Lucie , Gacoin Thierry , Gouillart Emmanuelle 
Published: August 2022

AbstractThermal properties of aqueous alkali silicates have been investigated to establish a fundamental understanding of the structural state of silicate network and its impact on intumescence, up to 450°C. Foaming behavior is dependent upon the type of alkali ion (Na, K, Li) as well as composition as evidenced from a combination of tools involving thermogravimetric analysis, nuclear magnetic resonance, and X‐ray diffraction. Na silicates show extensive foaming, Li‐silicates do not foam, whereas K‐silicates exhibit an intermediate behavior depending upon the starting state and heating kinetics. Crystallization is observed for K‐ and Li‐silicates but not in the case of Na‐silicates and appears to be a limiting factor for macroscopic structural expansion. Quantitative analysis of different species reveals the network to be relatively mobile, in terms of its ability to reorganize, in pre‐dried (at 150°C) Na‐silicates. A reduction in this mobility is seen for K‐silicates as crystallization reduces K ions and silanols in the amorphous phase at and above 150°C, thus reducing the extent of foaming. In contrast, phase separation coupled with crystallization resulting in a complete exit of Li ions from the amorphous phase tends to suppress completely the intumescent phenomenon.
Study on the surface properties of different commercially available CAD/CAM materials for implant‐supported restorations
Authors: Vulović Stefan , Todorović Aleksandar , Stančić Ivica , Popovac Aleksandra , Stašić Jovana N. , Vencl Aleksandar , Milić‐Lemić Aleksandra 
Published: August 2022

AbstractObjectiveTo determine if there are any differences in surface characteristics (surface roughness and contact angle) among different CAD/CAM materials indicated for fabricating implant‐supported restorations, following all the material preparation protocols provided by the manufacturer.Materials and MethodsOne‐hundred forty‐four specimens were divided into six groups: RBC (resin‐based composite), PMMA (polymethyl methacrylate), PEEK (polyether ether ketone), ZP (zirconia polished), ZG (zirconia glazed) and CoCr4 (CoCr4 alloy). The experimental part included surface roughness (SR) and contact angle of water (WCA) analyses, fulfilled with Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM) view of surface topography. The data were analyzed using Kruskal‐Wallis test with a Dunn's post hoc analysis, the correlation between measurements was tested using Spearman's rank correlation coefficient and all data were presented as mean ± SD.ResultsZG specimens were significantly rougher compared to other groups (p ≤ 0.05). The WCA measurements revealed significantly lower mean values in ZG group (p ≤ 0.05), contrary to PEEK and CoCr4, where significantly higher mean values were observed, compared to other groups (p ≤ 0.05). There exist a moderate negative correlation between the SR and WCA (ρ = −0.41). AFM 3D and SEM 2D images presented more or less heterogeneous surface of all materials.ConclusionsThere were statistically significant differences in surface roughness and contact angle among tested material groups. Moderate negative correlation was found between surface roughness and contact angle of tested material groups.Clinical SignificanceThe study gives us a better understanding of influence of physicochemical characteristics of investigated materials on their surface properties and provides useful knowledge for future researches in a view of material's behavior under in vivo conditions, when it comes to a question of features related to surface quality, such as microbial adhesion, corrosion, wear, biocompatibility and esthetics.
Care disruptions among the homebound during the COVID‐19 pandemic: An analysis of the role of dementia
Authors: Reckrey Jennifer M. , Kim Patricia S. , Zhao Duzhi , Zhang Meng , Xu Emily , Franzosa Emily , Ornstein Katherine A. 
Published: August 2022

AbstractIntroductionSeriously ill people with dementia living at home may be particularly vulnerable to disruptions in their care during times of crisis. The study sought to describe care experiences of those receiving home‐based primary care in New York City during the COVID‐19 pandemic and compare the experiences of people with and without dementia.MethodsWe conducted a retrospective review of all electronic medical record notes between March 1, 2020 and December 30, 2020 among a sample of home‐based primary care recipients (n = 228), including all deaths that occurred in the spring of 2020. Drawing from administrative records and using an abstraction tool that included both structured (e.g., documented COVID‐19 exposure) and unstructured (e.g., text passage describing caregiver burden) data, we identified salient COVID‐19 related care experiences and identified and categorized major disruptions in care.ResultsBoth people with and without dementia experienced significant disruptions of paid caregiving, family caregiving, and home‐based services during the COVID‐19 pandemic. While the paid caregivers of people with dementia reported more burden to the home‐based primary care team as compared to people without dementia, we found little evidence of differences in quantity or type of COVID‐19 related disruptions relative to dementia status.DiscussionWhile those with dementia have distinct care needs, our findings emphasize the way that dementia may be one piece of a larger clinical picture of serious illness. In order to support all patients with high care needs in crisis, we need to understand the interdependence of clinical care, long‐term care, and family caregiving support for older adults and view dementia within the larger context of serious illness and care need.
Serine racemase modulation for improving brain insulin resistance
Authors: Duarte João M. N. 
Published: August 2022

AbstractThis Editorial highlights an interesting study in the current issue of the Journal of Neurochemistry in which Zhou et al. report new data showing that the ablation of serine racemase increases local insulin production in neurons of the hippocampus. The authors explored some of the possible mechanisms mediating the interaction between dampening production of D‐serine and the local synthesis of insulin, and they further propose that stimulating insulin production could counteract hippocampal insulin resistance in Alzheimer's disease (AD). Most importantly, they leave open a number of questions that need to be experimentally addressed to ascertain whether D‐serine modulation of neuronal insulin expression can effectively improve insulin sensitivity in AD, as well as in metabolic disease with neurological impact.
Factors influencing the immune response over 15 months after SARS‐CoV‐2 infection: A longitudinal population‐wide study in the Faroe Islands
Authors: Petersen Maria Skaalum , Pérez‐Alós Laura , Armenteros Jose Juan A. , Hansen Cecilie B. , Fjallsbak Jógvan Páll , Larsen Sólrun , Hansen Jóhanna L. , Jarlhelt Ida , Kristiansen Marnar F. , við Streym Fríða , á Steig Bjarni , Christiansen Debes H. , Møller Lars F. , Strøm Marin , Andorsdóttir Guðrið , Gaini Shahin , Weihe Pál , Garred Peter 
Published: August 2022

AbstractBackgroundThe durability of SARS‐CoV‐2 antibody response and the resulting immunity to COVID‐19 is unclear.ObjectivesTo investigate long‐term humoral immunity to SARS‐CoV‐2.MethodsIn this nationwide, longitudinal study, we determined antibody response in 411 patients aged 0–93 years from two waves of infections (March to December 2020) contributing 1063 blood samples. Each individual had blood drawn on 4–5 occasions 1–15 months after disease onset. We measured total anti‐SARS‐CoV‐2 receptor‐binding domain (RBD) antibody using a qualitative RBD sandwich ELISA, IgM, IgG and IgA levels using an quantitative in‐house ELISA‐based assay and neutralizing antibodies (NAbs) using an in‐house ELISA‐based pseudoneutralizing assay. IgG subclasses were analyzed in a subset of samples by ELISA‐based assay. We used nonlinear models to study the durability of SARS‐CoV‐2 antibody responses and its influence over time.ResultsAfter 15 months, 94% still had detectable circulating antibodies, mainly the IgG isotype, and 92% had detectable NAbs. The distribution of IgG antibodies varied significantly over time, characterized by a biphasic pattern with an initial decline followed by a plateau after approximately 7 months. However, the NAbs remained relatively stable throughout the period. The strength of the antibody response was influenced by smoking and hospitalization, with lower IgG levels in smokers and higher levels in hospitalized individuals. Antibody stability over time was mainly associated with male sex and older age with higher initial levels but more marked decrease.ConclusionsThe humoral immune response to SARS‐CoV‐2 infection varies depending on behavioral factors and disease severity, and antibody stability over 15 months was associated with sex and age.
Rhetorical History as Institutional Work
Authors: Suddaby Roy , Israelsen Trevor , Bastien Francois , Saylors Rohny , Coraiola Diego 
Published: August 2022

AbstractRhetorical history has emerged as a useful theoretical construct that bridges the long recognized gap between historical and organizational scholarship. Despite its growing popularity, the precise nature of rhetorical history as a construct, its scope conditions, and its utility in resolving critical issues in historical organizational analysis remains unclear. This paper addresses these issues. We define rhetorical history and contextualize the construct by elaborating its relationship to associated concepts like collective memory, rhetoric, and narrative. We ground the construct by reviewing literature that has applied rhetorical history in both theory and empirical research. Our inductive review identifies four recurring themes in which rhetorical history is used to construct perceptions of; (a) continuity and discontinuity, (b) similarity and difference, (c) winners and losers, and (d) morality and immorality. We conclude with a discussion of how rhetorical history is an essential mechanism of institutional work.
Trends in lip, oral cavity, and pharyngeal cancer mortality in the United States, 1999–2019
Authors: Farhadi Kameron , Rojanaworarit Chanapong , Bhurosy Trishnee , Olokunlade Temitope , Karaye Ibraheem M. 
Published: August 2022

AbstractBackgroundChanges in the epidemiology of lip, oral cavity, and pharyngeal (LOCP) cancers have been reported in the United States. This study aimed to examine recent trends in LOCP cancer mortality in the United States from 1999 to 2019.MethodsNational mortality data were extracted from CDC WONDER, 1999–2019. International Classification of Diseases Codes, 10th Revision—C00‐C14, were used to identify decedents of malignant neoplasms of the lip, oral cavity, and pharynx. LOCP cancer mortality trends were assessed by fitting a Joinpoint regression model overall, and by race/ethnicity, sex, age, and US Census Region. Annual Percentage Changes (APC) were derived to estimate variations in mortality trends over time.ResultsThe age‐adjusted mortality rate (AAMR) for LOCP cancers was 2.5 per 100 000 (95% CI: 2.5–2.5), equivalent to 180 532 deaths during 1999–2019. Overall mortality trends have stabilized since 2009 (APC = 0.3; 95% CI: −0.1, 0.7), but an examination by subtype revealed rising mortality trends from cancers of the lip and oral cavity (APC = 1.2; 95% CI: 0.7, 1.6) and pharynx (APC = 3.2; 95% CI: 1.7, 4.8), and declining trends in malignancies of other and ill‐defined areas of the lip, oral cavity, and pharynx (APC = −2.7; 95% CI: −3.4, −2.0). Trend variations were also noted by sex, age, US Census Region, and race/ethnicity.ConclusionsThere are differential trends in mortality from LOCP cancers in the United States. Investigating the biological, individual, and contextual factors related to LOCP cancers would guide effective public health intervention efforts.
How paediatricians communicate with parents who access online health information
Authors: Karatas Ceylan , Caldwell Patrina HY , Scott Karen M 
Published: August 2022

AimsRecent years have seen an exponential increase in the proportion of parents searching for online health information on their child's medical condition. We investigated the experiences, attitudes and approaches of paediatricians interacting with parents who search for online health information and the impact on the doctor–parent relationship.MethodsThis qualitative study was conducted utilising semi‐structured interviews with 17 paediatric physicians, surgeons, anaesthetists and trainees working in an Australian children's hospital. Data were analysed through deductive and inductive thematic analysis using line‐by‐line coding.ResultsThree key themes were identified: paediatricians' experiences with, and attitudes towards, parents using online health information; paediatricians' communication approaches; and the perceived impact on the doctor–parent relationship. These themes demonstrated that most paediatricians acknowledged the information parents found and directed parents to reliable websites. Following discussions with Internet‐informed parents, a few changed their management plans and a few reported discouraging parents from further searching online.ConclusionsOur results indicate that paediatricians predominantly used patient‐centred communication strategies to care for patients in partnership with parents. Paediatricians contextualising online health information can contribute to a quality partnership with parents and facilitate shared decision‐making, potentially fostering better health outcomes for children. Our conclusions may inform clinicians' communication approaches when interacting with Internet‐informed parents and stimulate research about more effective doctor–parent communication approaches. In a digital age, paediatricians may benefit from employing more time‐efficient approaches to manage increasing workloads with their new role of digital stewardship of parents.
Reviewing demand regimes in open economies with Penn World Table data
Authors: Marques André M. 
Published: August 2022

AbstractThis paper uses the Penn World Table dataset to examine capacity utilization response to changes in the wage share in six developed countries from 1960 to 2019. Our vector autoregression model allows regression coefficients and volatilities to be time‐varying in nature. A rolling window shows that capacity utilization response to the wage share is unstable. We find that a 1‐standard deviation shock to the wage share generates a significant negative capacity utilization response in the U.S. and U.K. However, a rise in the wage share decreases capacity utilization of the remaining sample countries only conditional on exogenous wage share changes.