bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthetic demand flow generation using theproximity factor
Authors: Yalvac Ekin , Kay Michael G 
Published: August 2022

Abstract
One of the biggest challenges in designing a logistics network is predicting thedemand flows between all pairs of points in the network. Until recently, thegravity model was mainly used for estimating the demand flow between points.However, the gravity model uses historical data to estimate values for its multi-ple parameters and distance between pairs to forecast the demand flow. Distancevalues close to zero and unprecedented changes in demand flow data create nu-merical instability for the gravity model’s output. Hence, the proximity factor,a single parameter model that uses the relative ordering of pairs instead of dis-tance, was developed. In this paper, we systematically compare the proximityfactor and the gravity model. It is shown that the proximity factor is a robustand competitive alternative to the gravity model. According to our analysis,the proximity factor model can replace the gravity model in some applicationswhen no historical data is available to adjust the parameters of the latter.
Behavioral and Biologic Characteristics of Cancer-related Cognitive Impairment Biotypes
Authors: Mulholland Michele M. , Prinsloo Sarah , Kvale Elizabeth , Dula Adrienne N. , Palesh Oxana , Kesler Shelli R. 
Published: August 2022

Abstract
Psychiatric diagnosis is moving away from symptom-based classification and towards multi-dimensional, biologically-based characterization, or biotyping. We previously identified three biotypes of chemotherapy-related cognitive impairment based on functional brain connectivity. In this follow-up study, we evaluated additional factors to help explain biotype expression: neurofunctional stability, brain age, apolipoprotein (APOE) genotype, and psychoneurologic symptoms. We also compared the discriminative ability of a traditional, symptom-based cognitive impairment definition with that of biotypes. We found significant differences in cortical brain age (F = 10.86, p < 0.001), neurofunctional stability (F = 2.85, p = 0.040), APOE e4 genotype (X2 = 7.89, p = 0.048), and psychoneurological symptoms (Pillai = 0.339, p < 0.001) across the three biotypes. The more resilient (Biotype 2) demonstrated significantly higher neurofunctional stability compared to the other biotypes. Symptom-based classification of cognitive impairment did not differentiate biologic or other behavioral variables, suggesting that traditional categorization of cancer-related cognitive effects may miss important characteristics which could inform targeted treatment strategies. Additionally, biotyping, but not symptom-typing, was able to distinguish survivors with cognitive versus psychological effects. Our results suggest that Biotype 1 survivors might benefit from first addressing symptoms of anxiety and fatigue, Biotype 3 might benefit from a treatment plan which includes sleep hygiene, and Biotype 2 might benefit most from cognitive skills training or rehabilitation. Future research should include additional demographic and clinical information to further investigate biotype expression related to risk and resilience and examine integration of more clinically feasible imaging approaches.
Clinical Significance of Human Herpesvirus 6 and 7 Infection in a Tertiary Hospital: a Case-Control Study
Authors: Borque Pablo , Galán Juan Carlos , Romero Beatriz , Gioia Francesca , Escudero Rosa , Martín-Dávila Pilar , Moreno Santiago , Fortún Jesús 
Published: August 2022

Abstract
BackgroundHuman herpesviruses (HHV)-6 and HHV-7 are ubiquitous viruses with a global seroprevalence of around 90%, but their pathogenic significance remains unclear. MethodsFor 2 years, at our center, the presence of HHV6 and 7 DNA was investigated by PCR assay in blood, CSF, or other fluids. Epidemiological and clinical variables were collected from these patients and compared with those obtained in a negative-control cohort. Molecular detection of herpesvirus was performed using The Clart Entherpex kit (Genomica, Coslada, Spain), allowing simultaneous detection and identification of the eight human herpesviruses (HSV-1 to HHV-8) and Enterovirus (echovirus, poliovirus, and coxsackievirus).ResultsAll patients, cases, and controls were immunocompromised and had similar baseline clinical conditions. For all of them, molecular amplification of HHV-6 or 7 was requested as a diagnostic complement from different clinical pictures, mainly neurological symptomatology (80%). Corticosteroid treatment and viral or bacterial co-infection were independently associated with HHV-6 or 7 infections. When the impact of both viruses was analyzed independently, it was confirmed that HHV-6 was independently associated with higher 1-year mortality. ConclusionHHV-6 replication in CSF or blood may be a surrogate marker of mortality in the medium term in immunocompromised patients.
Negative-Pressure Pulmonary Edema following maxillofacial surgery: recognize to prevent further complications
Authors: Trabelsi Becem , Yedes Azza , Abdouli Hadhami , Mahouachi Issam , Saied Mohamed Ridha , Ali Mechaal Ben 
Published: August 2022

Abstract
Negative-pressure pulmonary edema (NPPE) is a rare respiratory complication due to acute upper airway obstruction occurring shortly after extubation. We report a case of NPPE in young adult patient who underwent an eventful general anesthesia. The patient presented laryngospasm followed by acute respiratory distress with pink frothy sputum following. The NPPE was initially misdiagnosed and a preventable tracheostomy was performed. NPPE was managed with mechanical ventilation and diuretics and the patient had full recovery. Every anesthesiologist should be aware of the diagnosis of NPPE. Early recognition and management are essential to prevent the morbidity associated with NPPE in young healthy patients.
Aerosolized antibiotics therapy for infected traumatic pulmonary pseudocysts: A case report
Authors: Tanikawa Atsushi , Kudo Daisuke , Hoshi Yosuke , Miyasaka Norihiro , Kushimoto Shigeki 
Published: August 2022

Abstract
Background: Traumatic pulmonary pseudocysts are caused after thoracic trauma. They do not usually require specific therapy when no complications arise, such as infection and bleeding. Complicated pulmonary pseudocysts, however, can be life threatening and require specific treatment. Although treatments of systemic antibiotics and surgery for infected cysts have been reported, to our knowledge, there are no reports on aerosolized antibiotics therapy for infected traumatic pulmonary pseudocysts.Case presentation: We present the case of a 31-year-old woman who was severely injured and suffered a blunt thoracic trauma in a vehicular accident crash, and required ventilator management in a previous hospitalization. Seven days later, she developed acute respiratory distress syndrome and was transferred to our department. We were unable to maintain proper oxygenation with ventilator management alone and established venous–venous extracorporeal membrane oxygenation. She then developed persistent bacteremia of Pseudomonas aeruginosa owing to infected traumatic pulmonary pseudocysts. On the 21st day of her hospitalization, the drainage for the enlarged cyst led to minor improvements in her respiratory condition. On the 32nd day of hospitalization, in addition to systemic antibiotics therapy, the aerosolized antibiotics therapy (inhalation of tobramycin (135 mg) every 12 h) was administered for the treatment of resistant infected pseudocysts. Her respiratory condition gradually improved, and the infected pseudocysts shrank. On the 43rd day of hospitalization, she was successfully removed extracorporeal membrane oxygenation.Conclusions: Aerosolized antibiotics therapy may be a potential option for patients with infected traumatic pulmonary pseudocysts when conventional therapies are not successful.
Longitudinal surveillance of three biomarkers to predict recurrence of hepatocellular carcinoma after radical resection
Authors: Tong Jingshu , Yang Yong , Lu Changjiang , Yu Xi , Mao Shuqi , Lu Caide 
Published: August 2022

Abstract
Background: Radical resection is a curative treatment for patients with hepatocellular carcinoma (HCC), but the incidence of recurrence remains high. We aimed to explore the performance of predicting HCC recurrence by longitudinal surveillance of the protein induced by vitamin K absence (PIVKA-II), alpha-fetoprotein (AFP), and lectin-reactive AFP (AFP-L3) during postoperative follow-up. Methods: Patients who underwent radical resection for HCC at the Ningbo Medical Centre Lihuili Hospital between January 2015 and December 2020 were included. All enrolled patients regularly monitor PIVKA-Ⅱ, AFP, AFP-L3 every 3 months during postoperative follow-up. The surveillance performance of PIVKA-Ⅱ, AFP, AFP-L3 during follow-up for the prediction of HCC recurrence was compared in patients. The Generalized Estimation Equation (GEE) was used to analyze the trends of the tumor biomarkers and interactions with time. Area under the receiver operator characteristic (AUROC) curves, the optimal cut-off value, the sensitivity and specificity were calculated to evaluate the performance of the three biomarkers. The recurrence-free survival (RFS) of patients with any of the elevated biomarkers was analyzed by Kaplan-Meier curves and the log-rank test. Results: The GEE analysis indicated that PIVKA-II, AFP, AFP-L3 in the recurrence patients were higher than the no recurrence patients during follow-up, PIVKA-Ⅱ and AFP showed increasing trends from 6 months before recurrence. In predicting recurrence, the AUROCs for PIVKA-Ⅱ, AFP, AFP-L3 and their combination were 0.885, 0.754, 0.781 and 0.885 respectively, the optimal cut-off value for PIVKA-Ⅱ, AFP, AFP-L3 was 29.5 mAU/ml, 10.7 ng/L, 1.5 % respectively. The sensitivity in predicting recurrence for PIVKA-Ⅱ, AFP, AFP-L3 and combination were 75.0%, 54.7%, 57.8% and 79.7% respectively. The RFS of patients with any of the biomarkers elevated during the follow-up was significantly shorter than that without elevated biomarkers (χ2=62.125, P<0.001).Conclusion: Longitudinal surveillance of PIVKA-II, AFP and AFP-L3 can effectively predict recurrence of HCC after operation.
Soil Microorganisms in Mixed Forest and Pure Forests of Ulmus pumila - Robinia pseudoacacia Based on Metagenomics
Authors: Chen Rui , Cui Haoran , Zhou Zhiqiang , Xu Qian , Ma Fengyun 
Published: August 2022

Abstract
AimsThe present study aimed to explore the characteristics of the microbial community in Ulmus pumila-Robinia pseudoacacia mixed forest soils in the Yellow River Delta.MethodsWe used metagenomics to analyse the structure and functional characteristics of the soil microbial community in a pure forest of Ulmus pumila, a pure forest of Robinia pseudoacacia, and a mixed forest of Ulmus pumila - Robinia pseudoacacia.ResultsIn total, 176 phyla and 21,760 species of microorganisms were identified. The proportion of bacteria (84.90% - 85.20%) was the highest among the microbial types in the soil of each forestland. Using the orthological database eggNOG, we identified the most dominant functional gene category is soil microbial metabolism. The active metabolism of carbohydrates in the KEGG pathway was prominent. In the carbon cycle, that soil microbial carbon metabolic activity in the mixed forests were greater than that in the pure forests. The gene abundance related to nitrogen metabolism was the highest in the Ulmus pumila - Robinia pseudoacacia mixed forest soil. ConclusionsMixed forests play specific roles in soil quality improvement by promoting the activity and functional metabolism of various soil microbiome communities.
RNA-seq Analysis Reveals Upregulation in ER -Stress-Related Genes Upon LCL-161 Treatment in SH-SY5Y Human Neuroblastoma Cells
Authors: Baran Burçin , Altun Zekiye , Yuan Hongling , Şanlav Gamze , Holyavkin Can , Aktaş Safiye , Olgun Nur 
Published: August 2022

Abstract
Background: SMAC mimetics (SM) are compounds that are developed on secondary mitochondria-derived activators of caspase (SMAC) protein structure and sensitize cancer cells to cell death, either alone or in the presence of death ligands or chemotherapies. However, their efficacy as a single agent or in combination with chemotherapy is highly variable and limited. In this study, we aimed to identify the transcriptomic changes in the SH-SY5Y cells upon induction with SM using RNA sequencing (RNA-seq). Hence, the total gene expression changes to understand the mechanism of action of SM in SH-SY5Y cells were examined. Methods and Results: RNA sequencing was performed on LCL-161 (a monovalent type of SM) treated SH-SY5Y neuroblastoma cells. The significantly upregulated and downregulated genes were studied using Real-time PCR (Q-PCR). In addition to the intrinsic apoptotic pathways, we identified significant upregulation in the endoplasmic reticulum (ER)-stress-related genes upon LCL-161 induction in RNA-seq results. Conclusion: These results demonstrated that ER stress response pathways might play a role in the SM response in addition to previously known apoptotic or necroptotic pathways. Further studies are required to establish whether ER stress pathways act as pro-survival or pro-apoptotic pathways in this response.
Characteristics of groundwater circulation and evolution in Yanhe spring basin driven by coal mining
Authors: Wang Zhenxing , LI Xiangquan , Hou Xinwei , Zhang Chunchao 
Published: August 2022

Abstract
The Yanhe spring basin located in the Jindong coal base is relatively short of water resources and the ecological environment is fragile. With the large-scale mining of coal resources and the intensification of human activities, the characteristics of regional groundwater circulation have evolved dramatically. In this paper, through the multivariate correlation analysis between spring flow and coal mining volume, karst groundwater extraction volume and atmospheric precipitation, the attenuation mechanism and main controlling factors of large karst springs are revealed. Combined with regional hydrogeological conditions, hydrochemistry and stable isotope characteristics, the mutual transformation relationship between different water bodies was analyzed, and the groundwater circulation model under the influence of coal mining was constructed. The research results show that: (1) The karst large spring flow and karst groundwater level in the Yanhe spring basin generally showed a downward trend. From 1957 to 2017, the spring flow attenuation range reached 75%, The three stages of 1956-1976, 1977-2002 and 2003-2017 were characterized by steady fluctuation, substantial decrease and slight decrease. (2) Coal mining in the central and southern parts of the mining area has a strong impact on karst groundwater. The main way of influence is that coal mining activities cause serious damage to the structure of the overlying aquifer in the karst groundwater recharge runoff area and attenuation of surface runoff, resulting in a decrease in karst water recharge. With the expansion of coal mining to the north, the burial depth of the coal seam increases, and the karst groundwater is a deep stagnant zone, and the influence of coal mining on it is weakened. (3) the hydrochemistry types of karst groundwater in Yanhe Spring basin have gradually diversified and local pollution has increased. (4) The main controlling factor of the karst spring flow attenuation and groundwater level drop is coal mining. In the rapid decline stage, karst groundwater exploitation is also Important factors affecting spring flow attenuation and water level decline. (5) Isotopic calculations show that surface water seepage and pore groundwater overcurrent are important sources of karst groundwater recharge. Coal mining directly affects surface runoff and pore groundwater aquifers, which in turn indirectly affects karst groundwater level and karst spring flow. (6) The groundwater circulation pattern under the coal mining conditions in the spring area can be divided into shallow, deep and local groundwater flow systems. The local groundwater flow system is mainly affected by coal mining, which is manifested as the centralized discharge of groundwater to the goaf.
TM-vector: A Novel Forecasting Approach forMarket stock movement with a Rich Representationof Twitter and Market data
Authors: Mousa Ramin , Heidary Majid , Sani Samin Dehbashi , Karkehabadi Ali , Mohammadi Ali 
Published: August 2022

Abstract
Stock market forecasting has been a challenging part for many analysts and researchers. Trend analysis, statistical techniques, and movement indicators have traditionally been used to predict stock price movements, but text extraction has emerged as a promising method in recent years. The use of neural networks, especially recurrent neural networks, is abundant in the literature. In most studies, the impact of different users was considered equal or ignored, whereas users can have other effects.n the current study, we will introduce TM-vector and then use this vector to train an IndRNN and ultimately model the market users' behavior. In the proposed model, TM-vector is simultaneously trained with both the extracted Twitter features and market information. Various factors have been used for the effectiveness of the proposed forecasting approach, including the characteristics of each individual user, their impact on each other, and their impact on the market, to predict market direction more accurately. Dow Jones 30 index has been used in current work. The accuracy obtained for predicting daily stock changes of Apple is based on various models, closed to over 95\% and for the other stocks is significant. Our results indicate the effectiveness of TM-vector in predicting stock market direction.
5-Year Outcomes of Comparing Double Kissing-Mini-culotte with Mini-culotte using Drug-eluting Stents for The Treatment of True Coronary Bifurcation Lesions
Authors: Tu Sheng , Zhang Linlin , Hu Fudong , Wang Ying , Chen Lianglong 
Published: August 2022

Abstract
Aims
To compare the clinical outcomes between Double Kissing Mini-culotte stenting (DKMC) and Mini-culotte (MC) stenting in treating patients with true coronary bifurcation lesions (CBLs) in the clinical real world.
Methods
This retrospective observational cohort study included 180 consecutive patients with true CBLs (Medina type 1,1,1; 1,0,1; 0,1,1). All the eligible patients underwent coronary angiography and percutaneous coronary intervention (PCI) with two-stent techniques in our hospital, among whom 97 received DKMC treatment (DKMC group) and 83 MC treatment. The primary clinical endpoints were the major adverse cardiovascular events (MACE), which included cardiac death, myocardial infarction, and target vessel/ lesion revascularization (TVR/TLR). The secondary endpoints were stent thrombosis, in-stent restenosis, and individual components of MACE.
Results
Quantitative coronary angiography analysis (at 1 year) showed that late lumen loss (0.12 ± 0.42mm vs. 0.22 ± 0.39mm, P = 0.045), segmental diameter restenosis of side branch (17.56 ± 10.23% vs. 23.62 ± 13.28%, P = 0.032) in the DKMC stenting group were lower as compared with MC group. There were similar rates of binary restenosis in the main parent vessel (1.2% vs. 2.9%) and the main branch (4.8% vs. 5.9% in both groups with a numerically lower rate of binary restenosis in the side branch in DKMC (6.2% vs. 13.2%, P = 0.141) irrespective of lack of significant differences. However, compared to MC stenting group, the cumulative event rate of MACE at 5 years (22.8% vs.8.3%, P = 0.007) and TVR/TLR (17.7% vs.6.3%, P = 0.018) in the DKMC stenting group was mainly caused by TVR/TLR. Especially, DKMC was related to a significant reduction in the primary and secondary endpoints in patients with high risk.
Conclusion
DKMC stenting is associated with lower late lumen loss and restenosis in the side branch, a lower rate of cumulative MACE, and TVR/TLR, and is more effective in treating true CBLs compared to MC stenting; yet, this needs to be further confirmed by a randomized clinical trial.
Lethal and sublethal effects of fluxametamide on rice-boring pest, rice stem borer Chilo suppressalis
Authors: Li Yao , Wang Ying Nan , Qian Cheng Long , Tang Tao , Shen Ning , Han Zhao Jun , Zhao Chun Qing 
Published: August 2022

Abstract
Fluxametamide is a novel isoxazoline insecticide and has been registered in Korea and Japan to control Lepidoptera pests. Rice stem borer, Chilo suppressalis (Walker), is a destructive Lepidoptera pest of rice in China, and novel effectively insecticides are required to be developed for controlling it due to its increasing resistance levels. Therefore, the lethal and sublethal effects of fluxametamide on C. suppressalis were investigated in the present study. In the lethal assay, the insecticidal activity of fluxametamide with median lethal dose (LD50) value of 1.308 mg/kg to the 4th instar larvae of C. suppressalis was higher than that of chlorantraniliprole (LD50, 3.112 mg/kg) and lower than that of emamectin benzoate (LD50, 0.006 mg/kg). In addition, the 3rd instar larvae of C. suppressalis were sensitive to fluxametamide than the 4th instar larvae. In the sublethal (LD10 and LD30) assay, the duration of 3rd to 6th instar larvae was significantly increased, whereas the pupal duration, pupation rate, and life-cycle rate were also significantly increased in F0 generation. Both length and weight of ovarian tube were decreased with the increase of fluxametamide dose, and they in the LD30 treatment were significantly lower than those of the control group. In F1 generation, only the duration of eggs was significantly increased with LD30 treatment of fluxametamide, other developmental parameters has no significant change. These results suggest that fluxametamide has excellent lethal and sublethal effects on C. suppressalis and probably is able to suppress the population growth and progeny of C. suppressalis.
COVID-19 Pandemic and Frontline Health Care Workers in Armenia: A Multi-Center Study
Authors: Sahakyan Serine , Musheghyan Lusine , Aslanyan Lusine , Grigoryan Zaruhi , Muradyan Diana , Khachadourian Vahe 
Published: August 2022

Abstract
Background From the early stages of the COVID-19 pandemic, the global medical community has put remarkable efforts to contain the burden of disease.Study aimTo assess the seroprevalence of antibodies against SARS-CoV-2 and its associated factors among frontline health care workers (HCW) in hospitals and primary healthcare (PHC) facilities in Armenia. MethodsWe implemented a cross-sectional study, where we collected blood samples for antibody testing and conducted a phone survey. We applied a clustered sampling strategy and selected the three largest public hospitals and 10 of the largest PHC facilities providing care to COVID-19 patients. FindingsOverall, 1148 HCW were included in the study, 769 from the hospitals. The prevalence of antibodies was higher among those HCWs who reported having close contact with COVID-19 patients versus those who did not have close contact (14.7% vs 9.17). HCWs from the hospitals were more than 2 times (OR = 2.28, 0.22 – 0.74, p < 0.002) and HCWs from ICU departments were more than 4 times (OR = 4.49, 0.33 – 1.95, p < 0.001) likely to have positive COVID-19 antibodies compared to those working in the PHC facilities. In the hospital setting the only risk factor significantly associated with having COVID-19 antibodies was having close contacts with COVID-19 patients (OR = 2.95; 95% CI: 1.32 – 6.52, p=0.008).ConclusionOur study demonstrated the importance of infection-control practices within healthcare facilities. Early detection or screening programs for HCWs to decrease in-hospital transmission and the role of proper PPE usage are the most effective approach to control the infection.