bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between first and second wave of COVID-19 outbreak in older people: the COPE multicentre European observational cohort study
Authors: Verduri Alessia , Short Roxanna , Carter Ben , Braude Philip , Vilches-Moraga Arturo , Quinn Terence J , Collins Jemima , Lumsden Jane , McCarthy Kathryn , Evans Louis , Myint Phyo K , Hewitt Jonathan ,   COPE Study Team, Clini Enrico , Rickard Frances , Hesford James , Mitchell Emma , Hartrop Kerr , Murphy Caitlin , Aggrey Ken , Bilan Jimmy , Quinn Thomas , Kelly Joanna , Murphy Caroline , Moug Susan , Barlow-Pay Fanella- , Khan Amarah , Espinoza Maria Fernanda Ramon , Kneen Thomas , Allafi Hala , Dafnis Anna , Vidal Maria Narro , Price Angeline , Pearce Lyndsay , Einarsson Alice , Mccrorie Eilidh BruceKirsty 
Published: August 2022

Abstract

Background
Effective shielding measures and virus mutations have progressively modified the disease between the waves, likewise healthcare systems have adapted to the outbreak. Our aim was to compare clinical outcomes for older people with COVID-19 in Wave 1 (W1) and Wave 2 (W2).

Methods
All data, including the Clinical Frailty Scale (CFS), were collected for COVID-19 consecutive patients, aged ≥65, from 13 hospitals, in W1 (February–June 2020) and W2 (October 2020–March 2021). The primary outcome was mortality (time to mortality and 28-day mortality). Data were analysed with multilevel Cox proportional hazards, linear and logistic regression models, adjusted for wave baseline demographic and clinical characteristics.

Results
Data from 611 people admitted in W2 were added to and compared with data collected during W1 (N = 1340). Patients admitted in W2 were of similar age, median (interquartile range), W2 = 79 (73–84); W1 = 80 (74–86); had a greater proportion of men (59.4% vs. 53.0%); had lower 28-day mortality (29.1% vs. 40.0%), compared to W1. For combined W1–W2 sample, W2 was independently associated with improved survival: time-to-mortality adjusted hazard ratio (aHR) = 0.78 [95% confidence interval (CI) 0.65–0.93], 28-day mortality adjusted odds ratio = 0.80 (95% CI 0.62–1.03). W2 was associated with increased length of hospital stay aHR = 0.69 (95% CI 0.59–0.81). Patients in W2 were less frail, CFS [adjusted mean difference (aMD) = −0.50, 95% CI −0.81, −0.18], as well as presented with lower C-reactive protein (aMD = −22.52, 95% CI −32.00, −13.04).

Conclusions
COVID-19 older adults in W2 were less likely to die than during W1. Patients presented to hospital during W2 were less frail and with lower disease severity and less likely to have renal decline.
Electoral and religious correlates of COVID-19 vaccination rates in Dutch municipalities
Authors: Afonso Alexandre , Votta Fabio 
Published: August 2022

Abstract
Vaccination campaigns amid the coronavirus disease 2019 (COVID-19) pandemic have been extensively politicized in a number of countries. Controlling for a number of demographic, social and economic factors, we find a negative statistical relationship between the aggregate vote share of the populist-right wing Forum for Democracy and the vaccination rate against COVID-19 across Dutch municipalities. We also find a negative relationship between the proportion of individuals with reformed Protestant and Muslim religious beliefs. These relationships can possibly be related to religious worldviews or mistrust towards authority. These results show that the politicization of health behaviours can have detrimental effects on public health campaigns.
Decoding the Emeishan Permian mantle plume in the southeastern margin of Tibet from the seismic signature of the local lithosphere
Authors: Hu Jiafu , Yang Haiyan , Badal José , Peng Hengchu , Miao Suqiu 
Published: August 2022

SUMMARY
The Emeishan large igneous province (ELIP), which is located along the southeastern margin of Tibet, is widely regarded as the erosional remnants of voluminous Permian mafic volcanic successions that were associated with mantle plume activity. In addition, evidence for the eruption of the mantle plume and its signature of lithospheric modification should have been retained in the lithosphere after cooling of the plume. Here we use calculated compressional- and shear wave receiver functions (PRFs and SRFs, respectively) from &gt;750 broad-band stations, together with heat flow and Bouguer gravity anomaly data, to investigate the seismic signature within the lithosphere beneath the southeastern margin of Tibet. Our results from the inner zone (INZ) of the ELIP indicate that the ∼60 km depth of the Moho interpreted from depth-migrated PRF images is consistent with that inferred from SRFs and is deeper than that in the region surrounding the INZ, which shows a continuous positive converted phase at ∼35–40 km depth. The crustal geometry and physical properties show a 15–20-km-thick mafic underplated layer that extends for 150–200 km in the E–W direction and ∼400 km in the N–S direction along the base of the crust in the northeastern INZ and its surrounding region. We interpret the underplated layer as the concealed Emeishan plume hotspot track and suggest that the head of the postulated mantle plume is centred approximately beneath Panzhihua City and its surroundings. We propose a new geodynamic model for the formation of the ELIP, in which the lower–middle crust has been strengthened by voluminous mafic intrusions and underplating, whereas the Yangtze Craton in the plume region has been destroyed by removing the base of the lithosphere.
Could thermal pressurization have induced the frequency-dependent rupture during the 2019 Mw8.0 Peru intermediate-depth earthquake?
Authors: Luo Heng , Zeng Hongyu , Shi Qibin , Wang Teng , Liao Mingsheng , Hu Jiashun , Wei Shengji 
Published: August 2022

SUMMARY
The rupture process of earthquakes at intermediate-depth (∼70–300 km) have rarely been illuminated by a joint analysis of geodetic and seismic observations, hindering our understanding of their dynamic rupture mechanisms. Here we present detailed rupture process of the 2019 Mw8.0 Peru earthquake at the depth of 122 km depth, derived with a holistic approach reconciling InSAR and broad-band seismic waveform data. The joint inversion of InSAR observations and teleseismic body waves results in a finite rupture model that extends ∼200 km along strike, with unilateral rupture towards north that lasted for ∼60 s. There are four major slip patches in the finite fault model which are well corresponding to the position and timing of the sources in back-projection and multiple points source results. The largest slip patch, which occurred ∼40 s after the rupture initiation, had a longer and smoother rise time, and radiated much weaker high-frequency seismic waves compared to other smaller slip patches. This distinct frequency-dependent rupture could be explained by a strong dynamic weakening mechanism. We question whether thermal pressurization of pore free water rather than thermal run away could be such a mechanism. Our frequency content analysis could be generalized to study other earthquakes including those deeper than 300 km.
Effects of large aftershocks on spatial aftershock forecasts during the 2017–2019 western Iran sequence
Authors: Asayesh Behnam M , Zafarani Hamid , Hainzl Sebastian , Sharma Shubham 
Published: August 2022

SUMMARYOn 12 November 2017, an earthquake with a moment magnitude of 7.3 struck the west of Iran near the Iraq border. This event was followed about 9 and 12 months later by two large aftershocks of magnitude 5.9 and 6.3, which together triggered intensive seismic activity known as the 2017–2019 Kermanshah sequence. In this study, we analyse this sequence regarding the potential to forecast the spatial aftershock distribution based on information about the main shock and its largest aftershocks. Recent studies showed that classical Coulomb failure stress (CFS) maps are outperformed by alternative scalar stress quantities, as well as a distance-slip probabilistic model (R) and deep neural networks (DNN). In particular, the R-model performed best. However, these test results were based on the receiver operating characteristic (ROC) metric, which is not well suited for imbalanced data sets such as aftershock distributions. Furthermore, the previous analyses also ignored the potential impact of large secondary earthquakes. For the complex Kermanshah sequence, we applied the same forecast models but used the more appropriate MCC-F1 metric for testing. Similar to previous studies, we also observe that the receiver independent stress scalars yield better forecasts than the classical CFS values relying on the specification of receiver mechanisms. However, detailed analysis based on the MCC-F1 metric revealed that the performance depends on the grid size, magnitude cut-off and test period. Increasing the magnitude cut-off and decreasing the grid size and period reduce the performance of all methods. Finally, we found that the performance of the best methods improves when the source information of large aftershocks is additionally considered, with stress-based models outperforming the R model. Our results highlight the importance of accounting for secondary stress changes in improving earthquake forecasts.
Joint inversion based on variation of information—a crustal model of Wilkes Land, East Antarctica
Authors: Lösing Mareen , Moorkamp Max , Ebbing Jörg 
Published: August 2022

SUMMARY
By combining gravity and magnetic data in a joint inversion approach, 3-D information on the crustal structure of Wilkes Land, East Antarctica, is obtained and possible geological features become evident. Both data sets are combined through a coupling method which decreases the variation of information (VI) so data misfit and model dissimilarity are minimized simultaneously. In this manner, statistically compatible inversion results are obtained. The suitability of the method is demonstrated through a synthetic example using magnetic data and pseudo-gravity. Subsequently, we apply the method to gravity residuals and magnetic data and identify matching features of high magnitude density and susceptibility. Prominent structures in NW–SE direction along the edge of the Mawson craton and at the presumed Australo-Antarctic and Indo-Antarctic terrane boundaries are enhanced. Given the structural similarity between inverted susceptibility and density, and a strong indication of a parameter relationship, we suggest a clustering approach in order to differentiate distinct groups with similar parameter properties. The spatial distribution of these clusters reveals possible geological structures that agree with previous 2-D studies and rock measurements from the Indian and Australian continents. This shows that the VI joint inversion is a convenient approach for remote regions like East Antarctica with sparse geological samples.
Does the conditional maternal benefit programme reduce infant mortality in India?
Authors: Aizawa Toshiaki 
Published: August 2022

Abstract
India, which suffers from the largest number of infant deaths in the world, introduced the conditional maternity benefit programme, ‘Indira Gandhi Matritva Sahyog Yojana’ (IGMSY), to provide cash directly to pregnant and lactating women contingent on specified maternal and infant healthcare uses. This study estimates the impact of this programme on infant mortality for the first 12 months after birth, exploiting the pilot phase of IGMSY as a natural experiment in which 52 districts were randomly chosen as pilot districts. In the matched-pair difference-in-differences framework, the treatment effect on survival rate is estimated through the fully data-driven random survival forest approach. The results show that IGMSY reduced the infant mortality rate by 8.32% in treatment districts, with 1.53 fewer deaths per 1000 live births [95% prediction interval: 1.26–1.80]. The size of the effect substantially varies even within the first 12 months, indicating larger reductions in the neonatal period, and after the first 6 months. The results also reveal greater reductions among boys and children in urban areas.
Disease correction in mucopolysaccharidosis type IIIB mice by intraparenchymal or cisternal delivery of a capsid modified AAV8 codon-optimized NAGLU vector
Authors: Rouse Courtney J , Hawkins Kimberley , Kabbej Nadia , Dalugdug Justin , Kunta Aishwarya , Kim Mi-Jung , Someya Shinichi , Herbst Zachary , Gelb Michael , Dinelli Isabella , Butterworth Elizabeth , Falk Darin J , Rosenkrantz Erinn , Elmohd Hamza , Khaledi Hamid , Mowafy Samar , Ashby Frederick , Heldermon Coy D 
Published: August 2022

Abstract
Mucopolysaccharidosis type IIIB (MPS IIIB) is an autosomal recessive lysosomal storage disease caused by mutations in the gene that encodes the protein N-acetyl-glucosaminidase (NAGLU). Defective NAGLU activity results in aberrant retention of heparan sulfate within lysosomes leading to progressive central nervous system (CNS) degeneration. Intravenous treatment options are limited by the need to overcome the blood–brain barrier and gain successful entry into the CNS. Additionally, we have demonstrated that AAV8 provides a broader transduction area in the MPS IIIB mouse brain compared with AAV5, 9 or rh10. A triple-capsid mutant (tcm) modification of AAV8 further enhanced GFP reporter expression and distribution. Using the MPS IIIB mouse model, we performed a study using either intracranial six site or intracisterna magna injection of AAVtcm8-codon-optimized (co)-NAGLU using untreated MPS IIIB mice as controls to assess disease correction. Disease correction was evaluated based on enzyme activity, heparan sulfate storage levels, CNS lysosomal signal intensity, coordination, activity level, hearing and survival. Both histologic and enzymatic assessments show that each injection method results in supranormal levels of NAGLU expression in the brain. In this study, we have shown correction of lifespan and auditory deficits, increased CNS NAGLU activity and reduced lysosomal storage levels of heparan sulfate following AAVtcm8-coNAGLU administration and partial correction of NAGLU activity in several peripheral organs in the murine model of MPS IIIB.
Fusobacterium nucleatum Extracellular Vesicles Promote Experimental Colitis by Modulating Autophagy via the miR-574-5p/CARD3 Axis
Authors: Wei Shuchun , Zhang Jixiang , Wu Xiaohan , Chen Meilin , Huang Hancheng , Zeng Suqi , Xiang Zixuan , Li Xiangyun , Dong Weiguo 
Published: August 2022

Abstract

Background
Ulcerative colitis (UC) may be exacerbated by Fusobacterium nucleatum (Fn) infection. However, the mechanism underlying Fn-mediated progression of UC has yet to be established. Here, we aimed to establish whether and how Fn-derived extracellular vesicles (Fn-EVs) participate in the development of experimental colitis through microRNAs (miRNAs).

Methods
EVs were isolated and purified by ultracentrifugation from Fn and Escherichia coli culture supernatants. Differentially expressed miRNAs in control intestinal epithelial cells (IECs) and Fn-EV–treated IECs were identified by miRNA sequencing. EVs were cocultured with IECs or administered to CARD3wt/CARD3–/– mice by gavage to assess inflammatory responses to and the mechanism of action of Fn-EVs.

Results
Fn-EVs promoted upregulation of proinflammatory cytokines (interleukin [IL]-1β, IL-6, tumor necrosis factor α), downregulation of anti-inflammatory IL-10 and intercellular tight junction proteins ZO-1 and occludin, and epithelial barrier dysfunction in IECs. Fn-EVs significantly aggravated experimental colitis in mice associated with Fn-EV–mediated downregulation of miR-574-5p expression and autophagy activation. Blockade of autophagy using chloroquine alleviates barrier damage exacerbated by Fn-EVs in vitro and in vivo. Inhibition of the miR-574-5p/CARD3 axis reduced the severity of colitis, epithelial barrier damage, and autophagy activation induced by Fn-EVs.

Conclusions
Here, we describe a new mechanism by which Fn-EVs mediate experimental colitis severity through miR-574-5p/CARD3–dependent autophagy activation, providing a novel target for UC monitoring and targeted therapy.
I-COPTIC: Implementation of community pharmacy-based testing for hepatitis C: Delphi consensus protocol
Authors:   The I-COPTIC Collaboration, Cook Charlotte , Reid Leila , Smith Stuart , Crockford Deborah , El Sharkawy Ahmed M , McPherson Stuart , Wright Mark , Radley Andrew , Malik Hassan , Keall Sandie , Catt Janet , Shah Sital , Hampton Helen , Powell Julia , Morris Danny , Boothman Helen , Khakoo Salim I , Parkes Julie , Buchanan Ryan M 
Published: August 2022

AbstractObjectiveThe World Health Organisation aims to eliminate Hepatitis C (HCV) by 2030. To achieve this, targeted testing needs to be widely available. Studies have demonstrated that community pharmacies can deliver effective targeted testing for HCV and the National Health Service in England has commissioned a national service. However, a recent survey of HCV operational delivery networks has shown limited uptake of this service. The objective of this protocol is to guide the formation of a consensus statement to facilitate the widespread implementation of community pharmacy-based targeted testing for HCV.MethodWe will use a modified Delphi method. A purposive selection of panel participants will be identified and recruited from a national survey and via chain-referral sampling. The main inclusion criteria for selection is direct involvement in the implementation of an HCV testing service in pharmacies. We aim for a heterogenous group, encompassing all aspects of the testing service. We will conduct a three round Delphi. The first round will consist of open questions which will be qualitatively analysed using thematic analysis with a framework method based on the WHO Health Systems Framework. This analysis will generate statements, that will be sent to the participants in the second round. A third round will be used where consensus is not reached.ConclusionsThe findings from this Delphi consensus study will facilitate the widespread implementation of targeted testing for HCV in community pharmacies.
Inexact Newton-CG algorithms with complexity guarantees
Authors: Yao Zhewei , Xu Peng , Roosta Fred , Wright Stephen J , Mahoney Michael W 
Published: August 2022

Abstract
We consider variants of a recently developed Newton-CG algorithm for nonconvex problems (Royer, C. W. & Wright, S. J. (2018) Complexity analysis of second-order line-search algorithms for smooth nonconvex optimization. SIAM J. Optim., 28, 1448–1477) in which inexact estimates of the gradient and the Hessian information are used for various steps. Under certain conditions on the inexactness measures, we derive iteration complexity bounds for achieving $\epsilon $-approximate second-order optimality that match best-known lower bounds. Our inexactness condition on the gradient is adaptive, allowing for crude accuracy in regions with large gradients. We describe two variants of our approach, one in which the step size along the computed search direction is chosen adaptively, and another in which the step size is pre-defined. To obtain second-order optimality, our algorithms will make use of a negative curvature direction on some steps. These directions can be obtained, with high probability, using the randomized Lanczos algorithm. In this sense, all of our results hold with high probability over the run of the algorithm. We evaluate the performance of our proposed algorithms empirically on several machine learning models. Our approach is a first attempt to introduce inexact Hessian and/or gradient information into the Newton-CG algorithm of Royer & Wright (2018, Complexity analysis of second-order line-search algorithms for smooth nonconvex optimization. SIAM J. Optim., 28, 1448–1477).
Security in the Asia-Pacific and signaling at sea
Authors: Chao Brian C , Cho Hyun-Binn 
Published: August 2022

Abstract
How do states signal resolve and conduct coercive diplomacy differently on land and at sea? This question has important implications for security in the Asia-Pacific, which is predominantly a maritime region. While the field of International Relations has been criticized for exhibiting a Cold War and European bias, this article is based on the observation that the field may suffer from continentalism: a reliance on land-based issues and ideas. We thus examine the potential for incorporating the maritime domain more explicitly into IR to better address the challenges to security in the Asia-Pacific. Specifically, we consider how signaling restraint, costly signals of resolve, and engaging in limited conflicts to conduct violent coercive diplomacy differ on land and at sea. Our findings suggest that addressing the challenges to security in the Asia-Pacific can benefit from a deeper understanding of signaling, coercive diplomacy, and international relations in the maritime domain.
Labor Market Discrimination and Sorting: Evidence From South Africa
Authors: Abel Martin 
Published: August 2022

Abstract
This paper collects a unique data set of classified ads and exploits quasi-random variation in the applicant pool composition to show that there exists hiring discrimination against immigrants in South Africa’s informal sector. Consistent with a tournament models in which immigrants are penalised, I find that both immigrant and native job seekers receive more employer clicks on their profile when being pooled with immigrant job applicants. Results also show that immigrants search further away, especially if they live in areas with high employer discrimination. This spatial sorting presents an important cost of discrimination that has largely been ignored in the literature.
Biochemical characterization of medaka (Oryzias latipes) fibrinogen gamma and its gene disruption resulting in anemia as a model fish
Authors: Meng Qi , Watanabe Yuko , Tatsukawa Hideki , Hashimoto Hisashi , Hitomi Kiyotaka 
Published: August 2022

Abstract
At the final stages of blood coagulation, fibrinogen is processed into insoluble fibrin by thrombin resulting in fibril-like structure formation. Via further cross-linking reactions between the fibrin gamma subunit by the catalytic action of blood transglutaminase (Factor XIII), this molecule gains further physical stability. Meanwhile, since fibrinogen is expressed in various cells and tissues, this molecule can exhibit other functions apart from its role in blood coagulation. To create a system studying on aberrant coagulation and investigate the physiological functions, using a model fish medaka (Oryzias latipes), we established gene-deficient mutants of fibrinogen gamma subunit protein in parallel with its biochemical analysis, such as tissue distribution pattern and substrate properties. By genetic deletion via genome editing, two distinct mutants displayed retardation of blood coagulation. The mutants showed lower hematocrit with aberrant erythrocyte maturation, which indicates that fibrin deficiency caused severe anemia, and also appeared as a model for investigation of the fibrin function.