bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gonadotropin releasing hormone (GnRH) antagonist administration to decrease the risk of ovarian hyperstimulation syndrome in GnRH agonist cycles triggered with Human Chorionic Gonadotropin
Authors: Mills Ginevra , Dahan Michael H. 
Published: July 2022

Abstract
Purpose
In Gonadotropin releasing hormone(GnRH) agonist IVF, after administration of human-chorionic-gonadotropin(HCG) triggering, there is a risk of ovarian hyperstimulation syndrome(OHSS). Few methods exist to prevent OHSS in these cases. Therefore, we investigated the use of a GnRH antagonist to decrease the risk of OHSS, due to its ability to decrease VEGF production and function.
Method
A retrospective cohort study of 171-IVF patients at risk for developing OHSS after a GnRH agonist cycle with HCG trigger was performed from 2011–2019. The patient population consisted of women with an unexpected exuberant response to stimulation based on ovarian reserve testing and were triggered with hCG. Women were converted to a freeze-all cycle and received either cabergoline 0.5mg orally alone for 7 days from the collection(Group 1, n = 123) or received cabergoline 0.5mg orally and ganirelix, 250 mcg SC for 7–10 days(Group 2, n = 48). Results: Group 1 had more cases of moderate and severe OHSS than group 2-(25% vs. 10% p = 0.03, and 52% vs. 25% p = 0.001 respectively). Group 1 reported more abdominal discomfort and bloating than group 2(91% vs. 65% p < 0.001) and the presence of free fluid was more frequent in group 1 than group 2(74% vs. 35% p < 0.001). Hemoconcentration and electrolyte disturbances were less severe in group 2 than in group 1 (p < 0.001 all cases).
Conclusion
In patients at high risk for developing OHSS after hCG trigger in a GnRH agonist cycle, the addition of GnRH antagonists in the luteal phase may reduce the risk of developing moderate and severe OHSS. The GnRH antagonist likely leads to more rapid luteolysis and down regulation of VEGF production and receptor response, thereby decreasing the hallmark increased vascular permeability.
KMT2C is implicated in hypothalamic hamartoma resulting in central precocious puberty
Authors: Tian Sufang , Niu Li , Fan Wei , Xin Can , Wang Daizhong 
Published: July 2022

Abstract
Precocious puberty (PP) is defined as the onset of puberty in early childhood, which presents with testicular enlargement before 9 years in boys, and breast budding and the onset of menstruation before 8 years in girls. Hypothalamic hamartoma (HH) is among the most common cause of central PP (CPP). As the pathogenesis of HH has not been elucidated to date, we explored the underlying molecular changes in three HH cases encountered in order to provide clues for clinical treatment. All specimens were reviewed from a pathological standpoint and then checked using next-generation sequencing to elucidate gene mutation profiles. In all three cases with HH, the lysine-specific methyltransferase 2C (KMT2C/MLL3) missense mutations were found. Combined with its close relationship with estrogen-related cancers, we speculate that KMT2C is involved in the pathogenesis of CPP owing to the resultant changes in estrogenic levels and release of gonadotropin-releasing hormone.
Clinical Outcomes of instituting a Toric Pathway for cataract surgery at a tertiary referral teaching hospital
Authors: McCall Dominic , Samarawickrama Chameen 
Published: July 2022

Abstract
Objectives: To analyze the visual and refractive results for patients undergoing cataract surgery with insertion of a toric intraocular lens (IOL), pre and post implementation of a standardized pathway (Toric Pathway) in a large, public, teaching hospital. Methods: All data from patients which underwent cataract surgery and toric IOL insertion with an emmetropic target between January 2015 and December 2019 was collected and separated into pre and post Toric Pathway introduction (January 2017) in a retrospective chart review fashion. Any patients which had perioperative complications, no post-operative refraction, or notes were incomplete were excluded. One hundred and eighteen eyes (105 participants) were included in this study. Fifty-nine were in the Pre-Pathway group.Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), post-operative spherical equivalent refraction (Post OT SER) and post-operative cylinder (Post OT Cyl) were compared using multivariant regression analysis and Mann-Whitney U testing.Results: Pre-Pathway and Post-Pathway groups were similar across all variables, except the post-pathway group had higher pre-operative cylinder (mean 2.72+/-1.16D vs 2.90+/-0.75D, p = 0.025). Post-operative outcomes differed between groups for UDVA (mean LogMAR 0.20+/-0.19 vs 0.13+/-0.13, p = 0.049), Post OT Cyl (0.87+/-0.78D vs 0.47+/-0.54D, p<0.001) and the standard deviation of Post OT SER (-0.38+/-0.71D vs -0.31+/-0.42D, p = 0.005).Conclusions: Implementation of a standardized toric IOL pathway at a tertiary referral teaching hospital significantly improved post-operative UDVA, reduced postoperative cylinder and improved consistency in post-operative spherical equivalent refraction and should be considered for implementation across large teaching hospitals.
Direct ultrafast parametric amplification pumped by a picosecond thin-disk laser
Authors: Qian Liejia 
Published: July 2022

Abstract
Optical quadratic nonlinearity is ultrafast in nature, while parametric interaction usually manifests only the broadband characteristic [1]. Enormous progress has been made toward broadband phase-matching for parametric amplification and wide applications [1-3]. In existing devices of broadband parametric amplification, the power efficiency of conversion is restricted to approximately the energy efficiency, and the desire for the signal power enhancement necessitates additional pulse compression after amplification [4-10]. Here, we demonstrate ultrafast parametric amplification having an extraordinary power efficiency of 1155%; this allows the generation of intense femtosecond pulses without the need for a pulse stretcher and compressor. Direct femtosecond signal amplification by picosecond pumping is enabled by an ultrafast parametric environment in which the pre-delayed signal of faster speed gradually overtakes and effectively depletes the pump of slower speed as they propagate in a nonlinear crystal. The demonstrated technique should lead to breakthroughs in ultrafast lasers as well as applications.
The Effects of Early Pulmonary Rehabilitation and Diaphragm Kinesiotaping on Diaphragm Muscle Thickness in Patients with Severe COVID-19 Pneumonia in the Intensive Care Unit
Authors: AKSELİM Sinem , Dandinoğlu Taner , Topal Serra , Çalışkan Gülbahar 
Published: July 2022

Abstract
Purpose: The efficacy of early rehabilitation in patients in the intensive care unit (ICU) is apparent. However, it is still unclear in COVID-19 patients. Also, the effects of diaphragm kinesiotaping (KT) on outcomes and muscle thickness were not shown previously. Thus, we aimed to investigate the efficacy of rehabilitation and diaphragm KT in patients with severe COVID-19 pneumonia by evaluating with the US of the diaphragm. Methodology: Patients with severe COVID-19 pneumonia in ICU requiring high flow oxygen therapy included in the study. Patients with severe COVID-19 pneumonia in ICU requiring high flow oxygen therapy were divided into three groups: Group 1 (n=22) rehabilitation, group 2 (n=26) rehabilitation and diaphragm KT, Group 3 (n=24) control group-only standard ICU care. Ultrasonographic measurements of diaphragm thickness (DT) and thickening fraction (TF) were recorded repeatedly.Results: The demographic characteristics, mortality, and length of stay were not different between groups. However, invasive mechanic ventilation (IMV) requirement and the decrease in DT and TF values were significantly lower in the KT group. Baseline DT and TF values were found to impact IMV requirement. Cut-off values for these parameters are 2.85 mm and 37.95%, respectively. Conclusion: Baseline DT can be used to predict noninvasive ventilation failure. By the way, the patients who are more likely to develop respiratory failure should receive inspiratory muscle training exercises combined with general rehabilitation principles. Also, diaphragm KT should be included in the rehabilitation protocol.
An Optimal Load Indirect Matching Method without Parameter Identification and System Efficiency Optimization
Authors: Qiu Xueying , Sun Pan , Rong Enguo , Qiao Kangheng , Sun Jun , Wu Xusheng 
Published: July 2022

Abstract
In order to achieve efficient operation of WPT systems, the conventional direct impedance matching method that requires mutual inductance and load identification is often used, which makes the system complicated. In this paper, an indirect impedance matching method without parameter identification is proposed, especially for systems with large coupling factor and load variations. This method is based on the characteristic that the optimal voltage gain of the resonator is only related to its inherent parameters, and impedance matching can be achieved by controlling the voltage gain in real time. To further improve the efficiency of the system, a single-sided detuning design method is used to achieve soft switching of the inverter. Based on the optimal voltage gain expression derived by using both the indirect impedance matching method and the single-sided detuning design method, a compound control strategy for a series-series-compensated topology with dual-side power control is proposed to improve efficiency and stabilize the output voltage. A hardware prototype is built and a peak DC-to-DC efficiency with the optimal output resistance at about 28.9Ω is 91.58%. When the output resistance is 100Ω, the efficiency improved by 7% after using the proposed strategy.
Numerical simulation and experimental validation of deposited corners of any angle in direct ink writing
Authors: Tu Yongqiang , Hassan Alaa , Siadat Ali , Yang Gongliu , Chen Zhangwei 
Published: July 2022

Abstract
Direct ink writing (DIW) belongs to material extrusion based additive manufacturing (MEAM) and the molding quality of deposited corners has an impact on the geometrical quality of three dimensional (3D) parts fabricated by DIW. To fully understand the DIW process and improve the geometrical quality of parts, numerical simulations have been widely used to model the DIW process. However, the previous research works for numerical simulation of deposited corners could only achieve the corner simulation under the condition of small angle and failed to realize corner simulation of any angel. Herein, we propose an improved numerical simulation of deposited corners of any angle based on the use of volume of fluid (VOF) method and validate the proposed numerical simulation experimentally. For this purpose, the numerical simulation is conducted through geometrical modeling, meshes generation and boundary conditions determination. In the numerical simulation, deposited corner is realized by constructing two calculation areas where two nozzle velocities with the corner angle as the velocity direction angle are applied on the substrates of two calculation areas. The effectiveness of the proposed numerical model is validated through corners deposition experiments using a commercially available microcrystalline wax (MW)-based ink in a DIW 3D printer as simulated results fit experimental results well. The current work demonstrates an effective approach for the prediction of the deposited corners of any angle in DIW based on numerical simulations.
Global Analysis of Stochastic Nonlinear Dynamical Systems. Part 1: Adaptative Phase-Space Discretization Strategy
Authors: Benedetti Kaio C. B. , Gonçalves Paulo Batista , Lenci Stefano , Rega Giuseppe 
Published: July 2022

Abstract
An adaptative phase-space discretization strategy for the global analysis of stochastic nonlinear dynamical systems with competing attractors considering parameter uncertainty or noise is proposed. The strategy is based on the classical Ulam method. The appropriate transfer operators for a given dynamical system are derived and applied to obtain and refine the basins of attraction boundaries and attractors distributions and densities. A review of the main concepts of parameter uncertainty and stochasticity from a global dynamics perspective is given, and the necessary modifications to the Ulam method are addressed. The stochastic basin of attraction definition here used replaces the usual basin concept. It quantifies the probability of the response associated with a given set of initial conditions converging to a particular attractor. The phase-space dimension is augmented to include the extra dimensions associated with the parameter space for the case of parameter uncertainty, being a function of the number of uncertain parameters. The expanded space is discretized, resulting in a collection of transfer operators that enable obtaining the required statistics. Finally, a Monte Carlo procedure is conducted for the stochastic case to construct the proper transfer operator. The present formulation is employed in Part II to investigate the global dynamics of two archetypal nonlinear oscillators.
Two-Variable Boosting Bifurcation in a Hyperchaotic Map and Its Hardware Implementation
Authors: wang mengjiao , An Mingyu , Zhang Xinan , Iu Herbert Ho-Ching 
Published: July 2022

Abstract
There are few reports on the nondestructive adjustment of the oscillation amplitude of the chaotic sequence in the discrete map. To study the lossless regulation of the oscillation amplitude of chaotic sequences, this article proposes a new simple two-dimensional (2D) hyperchaotic map with trigonometric functions. It not only exhibits contains the offset boosting bifurcation and offset boosting coexistence attractors, but also
realizes the offset boosting of two state variables with respect to arbitrary parameters in the 2D map. The simulation results of bifurcation diagram, maximum Lyapunov exponent and attractor phase diagram show
that the map can produce complex dynamical behaviors. In addition, the introduction of new control parameters into the 2D hyperchaotic chaotic map can also make the hyperchaotic map exhibit rich multistable phenomena. At the same time, the common change of the initial state and the control parameters can realize the arbitrary switching and co-existence of the attractor in the phase plane. In the end, the 2D hyperchaotic map was tested and verified by hardware experiment platform.
Group Care in the first 1000 days: implementation and process evaluation of contextually adapted antenatal and postnatal group care targeting diverse vulnerable populations in high and low resource settings
Authors: Martens Nele , Crone Mathilde R , Hindori-Mohangoo Ashna , Hindori Manodj , Reis Ria , Hoxha Ilir , Abanga Jedidia , Matthews Shanaaz , Berry Lizette , Kleij Rianne MJJ van der , Marle M. Elske van den Akker-van , Damme Astrid van , Talrich Florence , Beeckman Katrien , Court Christine Mc , Rising Sharon Schindler , Rijnders Marlies 
Published: July 2022

Abstract
Background
Group Care (GC) improves the quality of maternity care, stimulates women’s participation and facilitates growth of women’s social support network. There is an urgent need to identify and disseminate the best mechanisms for implementing GC in ways that are feasible, context appropriate and sustainable. This protocol presents the aims and methods of an innovative implementation research project entitled Group Care in the first 1000 days (GC_1000), which addressed this need.
Aims
The aim of GC_1000 is to co-create and disseminate evidence-based implementation strategies and tools to support successful implementation and scale-up of GC in the first 1000 days in health systems throughout the world, with particular attention to the needs of ‘vulnerable’ populations.
Methods
In five inter-related work packages with specific tasks, objectives and deliverables we will systematically study the implementation and scale up of antenatal and postnatal GC in seven different countries. GC_1000 project will be based theoretically on the consolidated framework for implementation research (CFIR), while the process evaluation will be guided by ‘Realistic Evaluation’ principles. Data are gathered across all research phases and analysis at each stage is synthesized to develop Context-Intervention-Mechanism-Outcome configurations.
Discussion
While the GC_1000 study design comprises of several strengths, it also contains some limitations which we aim to counter in various ways. This four-year project will generate evidence-based knowledge about the integration of complex interventions in diverse health care systems and it will pave the way for sustained implementation of GC targeting vulnerable groups.
Drivers of child marriage in specific settings of Ethiopia, Indonesia, Kenya, Malawi, Mozambique and Zambia – findings from the Yes I Do! baseline study
Authors: Kok Maryse C. , Kakal Tasneem , Kassegne Abeje Berhanu , Hidayana Irwan , Munthali Alister , Menon J. Anitha , Pires Paulo , Gitau Tabither , Kwaak Anke van der 
Published: July 2022

Abstract
BackgroundChild marriage persists in many countries and has severe impacts on health, education, economic and social status of girls. Child marriage has many interlinked causes. This study aimed to explore the drivers of child marriage in specific contexts in Ethiopia, Indonesia, Kenya, Malawi, Mozambique and Zambia.MethodsThe study combined a household survey among youth (15-24 years) with focus group discussions and interviews conducted with youth (15-24 years) and parents. A variety of community stakeholders were interviewed as well. Logistic regression was done to explore associations between individual and family-level characteristics of young women and the occurrence of child marriage. Transcripts were analysed using an inductive approach. Narratives on the main drivers of child marriage across study contexts were written and inspired by the theory of normative spectrum.ResultsA lack of education was associated with the occurrence of child marriage in Ethiopia, Kenya and Zambia. In all countries, teenage pregnancy was associated with child marriage. In Ethiopia, Kenya and Mozambique, fathers’ education seemed a protective factor for child marriage. Narratives of study participants showed that in Ethiopia, Indonesia and (to a lesser extent) Kenya, child marriage was perceived as an ‘appropriate practice’ to avoid premarital sex or pregnancy, whether it involved sex with or without consent. In all countries, child marriage was driven by difficult economic circumstances, which were often intertwined with disapproved social circumstances, in particular teenage pregnancy, in case of Kenya, Malawi, Mozambique and Zambia. These circumstances made child marriage an ‘acceptable practice’. Some youth, particularly in Indonesia, made their own choices to marry early, making child marriage a ‘possible practice’.ConclusionsMultiple intersecting drivers, which were present in different degrees in each country setting, influenced the occurrence of child marriage. We found that child marriage is a manifestation of social norms, particularly related to girls’ sexuality, which are intersecting with other factors at individual, social, material, and institutional level – most prominently poverty or economic constraints. Child marriage was, in some cases, a result of girls’ agentic choices. Efforts to prevent child marriage need to take these realities of girls and their families into account.
Model Predictive Control for formation reconfiguration exploiting quasi-periodic tori in the cislunar environment
Authors: Capannolo Andrea , Zanotti Giovanni , Lavagna Michèle , Cataldo Giuseppe 
Published: July 2022

Abstract
Given the numerous possibilities that formation flying space missions can enable, being able to design and govern relative trajectories in this scenario is fundamental. Particularly interesting, due to the installation and operation of the Lunar Gateway, which will represent the next human outpost in the cislunar environment, will be the exploitation of formation flying missions in the vicinity of this lunar station. The nonlinear dynamics by which the Earth-Moon system is characterised offers the possibility to find bounded relative trajectories which can be used to design the formation. In order to best exploit the formation potential, some reconfiguration manoeuvres can be used, which by changing the relative geometry can increase the versatility and adaptation of the mission. In this paper, a Model Predictive Guidance and Control strategy is proposed and applied to perform rephasing manoeuvres in the harsh environment of the Near Rectilinear Halo Orbits. By including first a limited thrust constraint and then a collision avoidance, a more mission-oriented approach is provided to the system. To further increase the robustness of the on-board algorithms, an adaptive logic is provided to the different tuning weights involved in the Model Predictive Control scheme. In this way, a more flexible system is obtained, which is capable of optimally working also in the presence of a high-fidelity simulation scenario, including discrepancies with the simplified on-board dynamical model.
What are birds looking at? A large-scale motion-capture system reveals the visual attention of freely- behaving pigeons
Authors: Kano Fumihiro , Naik Hemal , Keskin Göksel , Couzin Iain , Nagy Mate 
Published: July 2022

Abstract
Using a large-scale motion-capture system and custom head-calibration methods, we reconstructed the head-centric view of freely behaving pigeons and examined how they orient their head when presented with various types of attention-getting objects at various relative locations. Pigeons predominantly employed their retinal specializations to view a visual target, namely their foveas projecting laterally (at an azimuth of ±75°) into the horizon, and their visually-sensitive “red areas” projecting broadly into the lower-frontal visual field. Pigeons used their foveas to view any distant object while they used their red areas to view a nearby food-related object on the ground (< 50 cm). Pigeons “fixated” a visual target with their foveas; the intervals between head saccades were longer when the visual target was viewed by birds’ foveas compared to when it was viewed by any other visual field region. Furthermore, pigeons used their right eye to observe food-related objects and their left eye to do so for threat-related or social stimuli. Despite the known difficulty in identifying where a bird is attending, we show that it is possible to estimate the visual attention of freely behaving individuals by tracking the projections of their retinal specializations in their visual field with cutting-edge methods.