bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerobic training with a self-selected or predetermined intensity on sleep parameters in adolescents with obesity: a randomized clinical trial
Authors: Lyra Maria Julia , Barros Tércio Araújo do Rego , Tenório Thiago Ricardo dos Santos , Gomes Willemax dos Santos , Germano-Soares Antônio Henrique , Freitas-Dias Ricardo , De-Mello Marco Túlio , Santos Marcos André Moura , Prado Wagner Luiz do 
Published: February 2022

Objectives To compare the effects of self-selected and predetermined intensity on sleep quality and duration, daytime sleepiness, and sleep efficiency of adolescents with obesity after 12 weeks of aerobic training.
Material and Methods Thirty-seven adolescents (12 girls), 13-18 years old, with obesity (BMI = 95th) were randomized into a predetermined intensity group (PIG), exercise intensity around 60-70% of heart rate reserve; or self-selected intensity group (SIG), the adolescents chose the speed/intensity at the beginning of each session and were able to change it every 5 minutes. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were used to assess sleep outcomes.
Results No differences were observed for PSQI [0.00 ± 2.00 vs 1.38 ± 2.7; p=0.195; d=0.60 (moderate effect)], sleep duration [-0.95 ± 1.2 vs -0.35 ± 1.6; p=0.358; d=0.41 (small effect)], ESS [(2.10 ± 3.9 vs 1.15 ± 4.5; p=0.195; d=0.23 (small effect)], and sleep efficiency [(81.5 ± 24.0 vs 79.4 ± 17.0; p=0.8.14; d=0.10 (trivial effect)] for the PIG and SIG groups, respectively.
Conclusion Aerobic training at a self- selected or predetermined intensity does not modulate sleep quality, sleep duration and efficiency, and daytime sleepiness, independent of intensity.
Spatial patterns in the contribution of biotic and abiotic factors to the population dynamics of three freshwater fish species
Authors: Chevalier Mathieu , Tedesco Pablo , Grenouillet Gael 
Published: February 2022

Background
Population dynamics are driven by a number of biotic (e.g., density-dependence) and abiotic (e.g., climate) factors whose contribution can greatly vary across study systems (i.e., populations). Yet, the extent to which the contribution of these factors varies across populations and between species and whether spatial patterns can be identified has received little attention.

Methods
Here, we used a long-term (1982–2011), broad scale (182 sites distributed across metropolitan France) dataset to study spatial patterns in the population’s dynamics of three freshwater fish species presenting contrasted life-histories and patterns of elevation range shifts in recent decades. We used a hierarchical Bayesian approach together with an elasticity analysis to estimate the relative contribution of a set of biotic (e.g., strength of density dependence, recruitment rate) and abiotic (mean and variability of water temperature) factors affecting the site-specific dynamic of two different size classes (0+ and >0+ individuals) for the three species. We then tested whether the local contribution of each factor presented evidence for biogeographical patterns by confronting two non-mutually exclusive hypotheses: the “range-shift” hypothesis that predicts a gradient along elevation or latitude and the “abundant-center” hypothesis that predicts a gradient from the center to the edge of the species’ distributional range.

Results
Despite contrasted life-histories, the three species displayed similar large-scale patterns in population dynamics with a much stronger contribution of biotic factors over abiotic ones. Yet, the contribution of the different factors strongly varied within distributional ranges and followed distinct spatial patterns. Indeed, while abiotic factors mostly varied along elevation, biotic factors—which disproportionately contributed to population dynamics—varied along both elevation and latitude.

Conclusions
Overall while our results provide stronger support for the range-shift hypothesis, they also highlight the dual effect of distinct factors on spatial patterns in population dynamics and can explain the overall difficulty to find general evidence for geographic gradients in natural populations. We propose that considering the separate contribution of the factors affecting population dynamics could help better understand the drivers of abundance-distribution patterns.
AVALIAÇÃO DAS PERDAS DE ÁGUA EM SISTEMA DE ABASTECIMENTO DE ÁGUA: ESTUDO NO SETOR PARQUE DAS NAÇÕES, PARNAMIRIM/RN
Authors: Pereira Sansara Félix , Tinôco Juliana Delgado 
Published: February 2022

As perdas de água são refletidas em impactos negativos, seja à população, à companhia de abastecimento de água e mesmo ao meio ambiente. Em relação às perdas reais, o volume perdido ocorre nas etapas de produção e distribuição da água, enquanto que as perdas aparentes correspondem ao volume de água consumido que não gera faturamento à companhia, seja por ligações clandestinas, fraudes e, principalmente, por submedição nos hidrômetros. O presente artigo apresenta o estudo desenvolvido no setor Parque das Nações do sistema de abastecimento de água do município de Parnamirim/RN, com o objetivo de diagnosticar as perdas de água existentes. Para tanto, dividiu-se a área de interesse em quatro subsetores e, com base em banco de dados e estimativas, foi elaborada a matriz de balanço hídrico proposta pela International Water Association (IWA), ferramenta que permite a estratificação dos componentes de consumo e perdas de água ao longo de um sistema. De posse dos balanços hídricos finalizados para o setor Parque das Nações e respectivos subsetores, verificou-se que essas regiões exibiram cenário semelhante, no qual as perdas totalizaram mais da metade do volume de água fornecido ao sistema de abastecimento, como também as perdas reais foram maiores que as perdas aparentes.
DIAGNÓSTICO DA GESTÃO DE POLÍTICA PÚBLICA AMBIENTAL DO MUNICÍPIO DE CUBATÃO/SP ACERCA DOS RESÍDUOS ELETROELETRÔNICOS.
Authors: Moraes Maria de Lourdes Leite , Santos Paulo Roberto Pereira 
Published: February 2022

Os Resíduos de Equipamentos Eletroeletrônicos (REEE) têm se apresentado como uma problemática contemporânea que exige distinta atenção dos setores públicos e privados. Apesar da Política Nacional de Resíduos Sólidos (PNRS) instituir a responsabilidade compartilhada sobre os REEE, os municípios brasileiros ainda não dispõem de políticas municipais e/ou ações para realizar o descarte e a logística reversa de maneira correta. Considerando esta premissa, o objetivo deste trabalho foi diagnosticar a situação da gestão pública ambiental de REEE no município de Cubatão/SP. A metodologia consistiu no levantamento bibliográfico e análise documental da legislação nacional e municipal, de entrevista semiestruturada com o gestor da secretaria de Meio Ambiente da prefeitura local e da análise de conteúdo de informações obtidas junto ao Grupo de Atuação Especial de Defesa do Meio Ambiente (GAEMA/MPSP) e junto à Agência Metropolitana da Baixada Santista (AGEM). Foi feita também uma coleta de dados quantitativos junto às lojas varejistas do município. Estas informações permitiram avaliar a existência de diretrizes e inquéritos civis do município quanto aos REEEs, dos indicadores locais de coleta, tratamento e destinação dos materiais triados nas cooperativas e da comercialização de EEE num determinado período, a fim de projetar a geração de REEE. Os resultados evidenciaram a ausência de ações, projetos, campanhas, educação ambiental e leis, que em suma compreendem a seara das políticas públicas dos REEE no município, assim como a falta de ações junto ao comércio a fim de fomentar e instruir uma política reversa. Somado a isso, os REEE não são recebidos e/ou tratados pelas cooperativas municipais. Evidenciadas as vulnerabilidades, foi redigido e aprovado um projeto de lei junto à Câmara Municipal para que, utilizando do recurso disposto nas políticas públicas de comando e controle, o município pudesse legislar diretamente sobre o REEE e nortear o planejamento de novas ações.
Crystal‐Field Engineering Control of an Ultraviolet–Visible‐Responsive Near‐Infrared‐Emitting Phosphor and Its Applications in Plant Growth, Night Vision, and NIR Spectroscopy Detection
Authors: Zhou Yunpeng , Li Cancan , Wang Yuhua 
Published: February 2022

AbstractBroadband near‐infrared (NIR) phosphor‐converted light‐emitting diodes (pc‐LEDs) have many prospective applications in areas related to food inspection, health management, plant growth, and night vision, because NIR phosphors are critical components of the corresponding devices. Given the wide‐ranging applicability of the material, this study is designed to comprehensively evaluate a series of novel NIR phosphors: BaMgGaxAl10–xO17:Cr3+ (x = 0, 1, 2, 3). The ultra‐low‐temperature (4 K) fluorescence spectroscopy and decay curve results confirm that Cr3+ occupies the four lattice sites of Al3+ in the matrix. Additionally, the introduction of Ga3+ increases the full‐width at half‐maximum (FWHM) of the NIR spectrum from 100 to 300 nm without affecting the fluorescence efficiency; it also considerably increases spectral coverage. An experiment to evaluate the applicability of the novel NIR phosphors reveals that the sunlight‐converting film prepared by applying the material combination of BaMgGa3Al7O17:0.02Cr3+ is able to effectively promote the growth of Chlorella. In addition, the NIR pc‐LED with a BaMgGa3Al7O17:0.2Cr3+ basis and 395‐nm LED chip has been proven to be an excellent candidate for applications in NIR spectral detection and night‐vision technology.
Subsystem decomposition and distributed state estimation of nonlinear processes with implicit time‐scale multiplicity
Authors: Debnath Sarupa , Sahoo Soumya Ranjan , Decardi‐Nelson Benjamin , Liu Jinfeng 
Published: February 2022

AbstractIn this work, we propose a subsystem decomposition approach and a distributed estimation scheme for a class of implicit two‐time‐scale nonlinear systems. Taking the advantage of the time scale separation, these processes are decomposed into fast subsystem and slow subsystem according to the dynamics. In the proposed method, an approach that combines the approximate solutions obtained from both the fast and slow subsystems to form a composite solution of the original system is proposed. Also, based on the fast and slow subsystems, a distributed state estimation scheme is proposed to handle the implicit time‐scale multiplicity. In the proposed design, an extended Kalman filter (EKF) is designed for the fast subsystem and a moving horizon estimator (MHE) is designed for the slow subsystem. In the design, the slow subsystem is only required to send information to the fast subsystem one‐directionally. The fast subsystem estimator does not send out any information. The estimators use different sampling times, that is, fast sampling of the fast state variables is considered in the fast EKF and slow sampling of the slow state variables is considered in the slow MHE. Extensive simulations based on a chemical process are performed to illustrate the effectiveness and applicability of the proposed subsystem decomposition and composite estimation architecture.
Prenatal phenotypic spectrum of full trisomy 18 in an Indian cohort
Authors: Sandal Sapna , Mahay Sunita Bijarnia , Dimri Gupta Nandita , Saxena Renu , Lall Meena , Dua Puri Ratna 
Published: February 2022

AbstractTrisomy 18 or Edward syndrome is a chromosomal disorder due to the presence of an extra chromosome 18. We describe the phenotype of five fetuses at different gestational ages, each highlighting a different aspect of trisomy 18. The clinical spectrum included increased nuchal translucency, fetal hydrops, congenital malformations of the central nervous system, congenital heart disease, radial ray defects, and characteristic facial gestalt. We made a comparison of prenatal ultrasonography and the autopsy findings. The fetal autopsy defined the craniofacial and digit anomalies better compared with sonography. The facial features of tall forehead, hypoplastic nares, microstomia, micrognathia, low set abnormal ears along with clenched hands, and short hallux are typical for trisomy 18 and help in planning the targeted cytogenetic or molecular tests. The diagnosis was established by either fluorescence in situ hybridization or quantitative fluorescent polymerase chain reaction or chromosomal microarray in the patients. This communication emphasizes the importance of detailed assessment for craniofacial and limb anomalies on prenatal ultrasonography which can prompt an early evaluation for trisomy 18.
Polygenic risk scores for neuropsychiatric, inflammatory, and cardio‐metabolic traits highlight possible genetic overlap with suicide attempt and treatment‐emergent suicidal ideation
Authors: Fanelli Giuseppe , Sokolowski Marcus , Wasserman Danuta ,   European College of Neuropsychopharmacology (ECNP) Network on Suicide Research and Prevention, Kasper Siegfried , Zohar Joseph , Souery Daniel , Montgomery Stuart , Albani Diego , Forloni Gianluigi , Ferentinos Panagiotis , Rujescu Dan , Mendlewicz Julien , De Ronchi Diana , Serretti Alessandro , Fabbri Chiara 
Published: February 2022

AbstractSuicide is the second cause of death among youths. Genetics may contribute to suicidal phenotypes and their co‐occurrence in other neuropsychiatric and medical conditions. Our study aimed to investigate the association of polygenic risk scores (PRSs) for 24 neuropsychiatric, inflammatory, and cardio‐metabolic traits/diseases with suicide attempt (SA) or treatment‐worsening/emergent suicidal ideation (TWESI). PRSs were computed based on summary statistics of genome‐wide association studies. Regression analyses were performed between PRSs and SA or TWESI in four clinical cohorts. Results were then meta‐analyzed across samples, including a total of 688 patients with SA (Neff = 2,258) and 214 with TWESI (Neff = 785). Stratified genetic covariance analyses were performed to investigate functionally cross‐phenotype PRS associations. After Bonferroni correction, PRS for major depressive disorder (MDD) was associated with SA (OR = 1.24; 95% CI = 1.11–1.38; p = 1.73 × 10−4). Nominal associations were shown between PRSs for coronary artery disease (CAD) (p = 4.6 × 10−3), loneliness (p = .009), or chronic pain (p = .016) and SA, PRSs for MDD or CAD and TWESI (p = .043 and p = .032, respectively). Genetic covariance between MDD and SA was shown in 86 gene sets related to drugs having antisuicidal effects. A higher genetic liability for MDD may underlie a higher SA risk. Further, but milder, possible modulatory factors are genetic risk for loneliness and CAD.
Organoplatinum Compounds as Anion‐Tuneable Uphill Hydroxide Transporters
Authors: Chen Li‐Jun , Wu Xin , Gilchrist Alexander M. , Gale Philip A. 
Published: February 2022

AbstractActive transport of ions uphill, creating a concentration gradient across a cell membrane, is essential for life. It remains a significant challenge to develop synthetic systems that allow active uphill transport. Here, a transport process fuelled by organometallic compounds is reported that creates a pH gradient. The hydrolysis reaction of PtII complexes results in the formation of aqua complexes that established rapid transmembrane movement (“flip‐flop”) of neutral Pt−OH species, leading to protonation of the OH group in the inner leaflet, generating OH− ions, and so increasing the pH in the intravesicular solution. The organoplatinum complex effectively transports bound hydroxide ions across the membrane in a neutral complex. The initial net flow of the PtII complex into the vesicles generates a positive electric potential that can further drive uphill transport because the electric potential is opposed to the chemical potential of OH−. The OH− ions equilibrate with this transmembrane electric potential but cannot remove it due to the relatively low permeability of the charged species. As a result, effective hydroxide transport against its concentration gradient can be achieved, and multiple additions can continuously drive the generation of OH− against its concentration gradient up to ΔpH>2. Moreover, the external addition of different anions can control the generation of OH− depending on their anion binding affinity. When anions displayed very high binding affinities towards PtII compounds, such as halides, the external anions could dissipate the pH gradient. In contrast, a further pH increase was observed for weak binding anions, such as sulfate, due to the increase of positive electric potential.
Synthesis and Screening of a DNA‐Encoded Library of Non‐Peptidic Macrocycles**
Authors: Koesema Eric , Roy Animesh , Paciaroni Nicholas G. , Coito Carlos , Tokmina‐Roszyk Michal , Kodadek Thomas 
Published: February 2022

AbstractThere is considerable interest in the development of libraries of non‐peptidic macrocycles as a source of ligands for difficult targets. We report here the solid‐phase synthesis of a DNA‐encoded library of several hundred thousand thioether‐linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N−H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind Streptavidin, a model target, with high affinity.
Atom Swapping on Aromatic Rings: Conversion from Phosphinine Pincer Metal Complexes to Metallabenzenes Triggered by O2 Oxidation
Authors: Masada Koichiro , Kusumoto Shuhei , Nozaki Kyoko 
Published: February 2022

AbstractHerein, we report a novel method for the synthesis of metallabenzenes by swapping the phosphorus atom in an aromatic phosphinine ring with transition metal fragments. The oxidation of a phosphine‐phosphinine‐phosphine pincer iridium complex by O2 triggered the replacement of the phosphorus atom of the phosphinine ring by an iridium fragment to afford iridabenzene. Dianionic rhodabenzene was also synthesized from a phosphinine rhodium complex by oxidation of the phosphorus atom, followed by subsequent reduction using metallic potassium. The aromaticity of the newly synthesized irida‐ and rhoda‐benzenes was evaluated both experimentally and theoretically.
Characterization of Multifunctional and Non‐stereoselective Oxidoreductase RubE7/IstO, Expanding the Functional Diversity of the Flavoenzyme Superfamily
Authors: Yan Yijun , Yu Zhiyin , Zhong Wei , Hou Xiaodong , Tao Qiaoqiao , Cao Minhang , Wang Li , Cai Xiaofeng , Rao Yijian , Huang Sheng‐Xiong 
Published: February 2022

AbstractFlavin‐dependent enzymes enable a broad range of redox transformations and generally act as monofunctional and stereoselective catalysts. Herein, we report the investigation of a multifunctional and non‐stereoselective FMN‐dependent oxidoreductase RubE7 from the rubrolone biosynthetic pathway. Our study outlines a single RubE7‐catalysed sequential reduction of three spatially distinct bonds in a tropolone ring and a reversible double‐bond reduction and dehydrogenation. The crystal structure of IstO (a RubE7 homologue) with 2.0 Å resolution reveals the location of the active site at the interface of two monomers, and the size of active site is large enough to permit both flipping and free rotation of the substrate, resulting in multiple nonselective reduction reactions. Molecular docking and site mutation studies demonstrate that His106 is oriented towards the substrate and is important for the reverse dehydrogenation reaction.
Boosted Inner Surface Charge Transfer in Perovskite Nanodots@Mesoporous Titania Frameworks for Efficient and Selective Photocatalytic CO2 Reduction to Methane
Authors: Sun Qi‐Meng , Xu Jing‐Jing , Tao Fei‐Fei , Ye Wen , Zhou Chang , He Jing‐Hui , Lu Jian‐Mei 
Published: February 2022

AbstractExploring high‐efficiency and stable halide perovskite‐based photocatalysts for the selective reduction of CO2 to methane is a challenge because of the intrinsic photo‐ and chemical instability of halide perovskites. In this study, halide perovskites (Cs3Bi2Br9 and Cs2AgBiBr6) were grown in situ in mesoporous TiO2 frameworks for an efficient CO2 reduction. Benchmarked CH4 production rates of 32.9 and 24.2 μmol g−1 h−1 with selectivities of 88.7 % and 84.2 %, were achieved, respectively, which are better than most reported halide perovskite photocatalysts. Focused ion‐beam sliced‐imaging techniques were used to directly image the hyperdispersed perovskite nanodots confined in mesopores with tunable sizes ranging from 3.8 to 9.9 nm. In situ X‐ray photoelectronic spectroscopy and Kelvin probe force microscopy showed that the built‐in electric field between the perovskite nanodots and mesoporous titania channels efficiently promoted photo‐induced charge transfer. Density functional theory calculations indicate that the high methane selectivity was attributed to the Bi‐adsorption‐mediated hydrogenation of *CO to *HCO that dominates CO desorption.
Azulene‐Embedded [n]Helicenes (n=5, 6 and 7)
Authors: Duan Chao , Zhang Jianwei , Xiang Junjun , Yang Xiaodi , Gao Xike 
Published: February 2022

AbstractAzulene is a non‐benzenoid aromatic building block with unique chemical structure and physicochemical properties. By using the “bottom‐up” synthetic strategy, we synthesized three azulene‐embedded [n]helicenes ([n]AzHs, n=5, 6 and 7), in which one terminal azulene subunit was fused with n‐2 benzene rings. P‐ and M‐enantiomers were observed in the packing diagrams of [5]‐, and [6]AzHs. However, P‐ and M‐[7]AzHs could be isolated by recrystallization of the racemic mixture. These [n]AzHs were endowed with new properties through the azulene moiety such as low‐lying first electric state (S1), small optical energy gap and anti‐Kasha emission. [6]‐, and [7]AzHs exhibit strong chiroptical responses with high absorption dissymmetry factor (gabs) maxima of about 0.02, which is among the highest |gabs| values of helicenes in the visible range. These azulene‐embedded [n]helicenes contribute to the non‐benzenoid helicene library and allow the structure–property relationships to be better understood.
Improved performance of poly(styrene‐co‐butadiene) using butadiene graphitic nanoplatelets
Authors: Lee Se Jung , Jeon In‐Yup 
Published: February 2022

AbstractGraphene manufactured by the existing method (e.g., chemical oxidation) has limitations in application due to various disadvantages. Functionalized graphic nanoplates manufactured by mechanochemical reactions can solve physical and chemical defects. So, butadiene graphitic nanoplatelets (BDGNs) are first synthesized with solid graphite and butadiene gas by using a mechanochemical reaction. The product BDGNs have outstanding properties, including very good dispersion in common organic solvents (i.e., toluene), and can be used as a reinforcing filler for poly(styrene‐co‐butadiene) (PSB) because of their chemical affinity to butadiene units. BDGN/PSB_X (BDGN loading [X] = 0.2, 0.5, 1, or 2 wt.%) nanocomposites are readily prepared using a solution process. In result, the tensile strength and Young's modulus of the BDGN/PSB_0.5 nanocomposites increased by approximately 27.9% and 81.4%, respectively, compared with those of pure PSB. Because of the efficient load transfer from the PSB to the BDGNs through the good distribution and affinity of the BDGNs in the PSB, as well as the physical cross‐linking points of the BDGNs. Therefore, a mechanochemical reaction can form in situ a variety of graphitic nanoplatelets (GnPs) without additional reaction as a filler that has remarkable affinity with various polymers, including copolymers.