bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Variant Genetic Algorithm for a Specific Examination Timetabling
Problem in a Japanese University
Authors: Li Jiawei , Gonsalves Tad 
Published: June 2022

Background:
Examination Timetabling Problem which tries to find an optimal examination schedule for schools, colleges, and universities, is a well-known NP-hard problem. This paper presents a Genetic Algorithm variant approach to solve a specific examination timetabling problem common in Japanese colleges and universities.

Methods:
The proposed algorithm uses direct chromosome representation Genetic Algorithm and implements constraint-based initialization and constraint-based crossover operations to satisfy the hard and soft constraints. An Island model with varying crossover and mutation probabilities and an improvement approach called pre-training are applied to the algorithm to further improve the result quality.

Results:
The proposed model is tested on synthetic as well as real datasets obtained from Sophia University, Japan and shows acceptable results. The algorithm was fine-tuned with different penalty points combinations and improvement combinations.

Conclusion:
The comparison results support the idea that the initial population pre-training and the island model are effective approaches to improve the result quality of the proposed model. Although the current island model used only four islands, incorporating greater number of islands, and some other diversity maintenance approaches such as memetic structures are expected to further improve the diversity and the result quality of the proposed algorithm on large scale problems.
Design, Synthesis, Anti-microbial and Molecular Docking Studies
of Novel 5-Pyrazyl-2-Sulfanyl-1, 3, 4-Oxadiazole Derivatives
Authors: Das Rina , Mehta Dinesh Kumar , Gupta Sumeet , Dhanawat Meenakshi 
Published: June 2022

Background:
Chemical modification of Oxadiazole may lead to a potent therapeutic
agent. A series of novel 5-pyrazyl-2-sulfanyl-1, 3, 4-oxadiazole derivatives (5ag)
have been synthesised utilising pyrazinoic acid as a precursor. The new oxadiazole
compounds were docked against potential targets and evaluated for antibacterial and antitubercular
activity.

Method:
The 5-pyrazyl-2-substituted sulfanyl-1, 3,4-oxadiazole derivatives (5a-g) were
synthesized from the crucial intermediate 2-sulfanyl-5-pyrazyl-1, 3,4-oxadiazole (4),
which was prepared by treating the 2-pyrazyl hydrazide with CS2 and pyridine. IR,
1HNMR, 13C, MS and elemental analyses were used to confirm the chemical structures.

Results:
Antimicrobial activity was determined for each synthesized compound. Additionally,
compounds were evaluated for antitubercular activity against the Mycobacterium
Tuberculosis H37Rv strain. Compounds 5c, 5g, and 5a had a favourable antibacterial
profile, while 5c and 5g (MIC = 25 g/ml) demonstrated potential antitubercular activity
when compared to the other produced compounds. Molecular docking experiments
using V-Life Science MDS 4.6 supplemented the biological data.

Conclusion:
Each compound has been tested for antibacterial and antitubercular action
against a variety of microorganism strains and exhibits considerable activity. Additionally,
molecular docking analysis confirmed the experimental results by describing improved
interaction patterns.
A Study on the Bio-responses of a Freshwater Snail (Biomphalaria
alexandrina) to Fungal-derived Compounds
Authors: Mekawey Amal A.I. , Salah Ahmed M. , Yosri Mohammed 
Published: June 2022

Background:
Biomphalaria alexandrina snails, as transitional hosts of schistosomiasis,
plays an essential part in the spread of the illness. Control of these snails by
the substance molluscicides antagonistically influences the oceanic climate, causing poisonous
and cancer-causing consequences for non-target life forms.

Objective:
Looking for new naturally safe substances that can treat schistosomiasis disease
with minimal side effects on the environment and plants, fish wealth and do not affect
vital human functions.

Methods:
Fifty fungal species were used to evaluate their activity against Biomphalaria
alexandrina. Study the effect of the fungal extract on vital functions of Biomphalaria
alexandrina and fish wealth. Purification of active substances and identification of their
chemical structures.

Results:
Cladosporium nigrellum and Penicillium aurantiogresium metabolites were effective
against B. alexandrina snails, and the effects of promising fungal extracts sublethal
concentrations (IC10 & IC25) on the levels of steroid sex hormones, liver enzymes,
total protein, lipids, albumin and glucose were determined. Chemical analyses of this filtrate
separated a compound effective against snails; it was identified. Protein electrophoresis
showed that fungal filtrate affects the protein pattern of snails’ haemolymph. Little
or no mortality of Daphnia pulex individuals was observed after their exposure to sublethal
concentrations of each treatment.

Conclusion:
Certain compounds from fungal cultures could be safely used for biological
control of Biomphalaria alexandrina snails.
Biological Importance and Therapeutic Benefit of Rhamnocitrin:
A Review of Pharmacology and Analytical Aspects
Authors: Patel Dinesh Kumar 
Published: June 2022

Background:
Humans have a long history of the uses of plant based products, including
extracts and pure phytoconstituents for the treatment of human diseases in the different system of
medicine. In the developing countries, phytoproducts play an important role in the healthcare systems
due to their medicinal importance and pharmacological activities. Flavonoids class phytochemicals
are beneficial for human beings because of their free radical scavenging properties and
trace metals chelating potential. Flavonoids have inhibitory potential for the growth of bacteria and
virus mainly through enzyme inhibition functions and viral translation. Rhamnocitrin is also called
7- methyl-kaempferol is important flavonoids, which has been isolated from different medicinal
plants and has pharmacological activities in the medicine.

Methods:
Present paper describes the biological potential and health beneficial aspects of rhamnocitrin
in the medicine through the data analysis of published papers in the recent years in the
field of medicine and modern medical sciences. Scientific data on rhamnocitrin have been collected
from electronic databases such as PubMed, Google Scholar, Google, Scopus and Science Direct
in the present investigation and analyzed to know the biological importance and pharmacological
activities of rhamnocitrin. Pharmacological scientific data of rhamnocitrin have been collected and
analyzed in the present work with their analytical aspects.

Results:
Literature data analysis of different scientific work on rhamnocitrin revealed the biological
importance of rhamnocitrin in medicine. Rhamnocitrin is known to be a promising phytoconstituents
found to be present in medicinal plants with a wide range of biological activities. Rhamnocitrin
was found to have pharmacological activities, including anti-atherogenic, anti-oxidant,
anti-cancer, anti-bacterial, anti-inflammatory, enzymatic and neuroprotective potential. Further
biological effect of rhamnocitrin on adipocyte differentiation has been also studied in the present
work. Analytical data on rhamnocitrin signified the application of different analytical techniques
for the separation, isolation and identification of rhamnocitrin in medicine.

Conclusion:
Literature data analysis of different scientific research works revealed the biological
importance and therapeutic benefit of rhamnocitrin in medicine.
Wisdom of the Experts Versus Opinions of the Crowd in Hospital Quality Ratings: Analysis of Hospital Compare Star Ratings and Google Star Ratings
Authors: Ramasubramanian Hari , Joshi Satish , Krishnan Ranjani 
Published: June 2022

Background
Popular web-based portals provide free and convenient access to user-generated hospital quality reviews. The Centers for Medicare & Medicaid Services (CMS) also publishes Hospital Compare Star Ratings (HCSR), a comprehensive expert rating of US hospital quality that aggregates multiple measures of quality. CMS revised the HCSR methods in 2021. It is important to analyze the degree to which web-based ratings reflect expert measures of hospital quality because easily accessible, crowdsourced hospital ratings influence consumers’ hospital choices.

Objective
This study aims to assess the association between web-based, Google hospital quality ratings that reflect the opinions of the crowd and HCSR representing the wisdom of the experts, as well as the changes in these associations following the 2021 revision of the CMS rating system.

Methods
We extracted Google star ratings using the Application Programming Interface in June 2020. The HCSR data of April 2020 (before the revision of HCSR methodology) and April 2021 (after the revision of HCSR methodology) were obtained from the CMS Hospital Compare website. We also extracted scores for the individual components of hospital quality for each of the hospitals in our sample using the code provided by Hospital Compare. Fractional response models were used to estimate the association between Google star ratings and HCSR as well as individual components of quality (n=2619).

Results
The Google star ratings are statistically associated with HCSR (P<.001) after controlling for hospital-level effects; however, they are not associated with clinical components of HCSR that require medical expertise for evaluation such as safety of care (P=.30) or readmission (P=.52). The revised CMS rating system ameliorates previous partial inconsistencies in the association between Google star ratings and quality component scores of HCSR.

Conclusions
Crowdsourced Google star hospital ratings are informative regarding expert CMS overall hospital quality ratings and individual quality components that are easier for patients to evaluate. Improvements in hospital quality metrics that require expertise to assess, such as safety of care and readmission, may not lead to improved Google star ratings. Hospitals can benefit from using crowdsourced ratings as timely and easily available indicators of their quality performance while recognizing their limitations and biases.
Possible Contribution of Meaning in Life in Patients With Chronic Pain and Suicidal Ideation: Observational Study
Authors: Chytas Vasileios , Costanza Alessandra , Mazzola Viridiana , Luthy Christophe , Galani Vasiliki , Bondolfi Guido , Cedraschi Christine 
Published: June 2022

Background
Chronic pain is associated with an elevated risk of suicidal ideation (SI).

Objective
We aimed to examine if the presence or the search for Meaning in Life (MiL) are associated with less SI and explore whether MiL profiles emerge in our cohort. These profiles can be described as high presence–high search, high presence–low search, low presence–low search, and low presence–high search.

Methods
In this observational study, we recruited 70 patients who were referred to the Multidisciplinary Pain Center of the Geneva University Hospitals and who answered positively to question 9 on the Beck Depression Inventory, 2nd Edition, investigating SI. Patients who agreed to participate in the study were further investigated; they participated in a structured diagnostic interview to screen for psychiatric diagnoses. During this interview, they completed the Meaning in Life Questionnaire and the semistructured Scale for Suicide Ideation (SSI) to assess the characteristics and severity of SI.

Results
There was a statistically significant correlation between the presence of MiL subscale and the SSI. These 2 scales had a negative and statistically highly significant correlation (R=–.667; P<.001). The results also showed a negative and statistically highly significant correlation between the score of the search for MiL and the SSI (R=–.456; P<.001). The results thus pointed to the presence of MiL as a potential protective factor against the severity of SI, while the search for MiL is also a possible resiliency factor, although to a lesser extent. The profile low presence–low search grouped the vast majority (47%) of the patients; in these patients, the mean SSI score was 14.36 (SD 5.86), much higher compared with that of the other subgroups.

Conclusions
This study’s results point to MiL as a concept of interest regarding devising psychotherapeutic interventions for chronic pain patients in order to reduce the suicidal risk and more accurately determine patients’ suffering.
Burnout and Associated Psychological Problems Among Teachers and the Impact of the Wellness4Teachers Supportive Text Messaging Program: Protocol for a Cross-sectional and Program Evaluation Study
Authors: Agyapong Belinda , Wei Yifeng , da Luz Dias Raquel , Agyapong Vincent Israel Opoku 
Published: June 2022

Background
Stress, burnout, anxiety, and depression continue to be a problem among teachers worldwide. It is not presently known what the prevalence and correlates for these psychological problems are among teachers in Alberta and Nova Scotia. It is also not known if a supportive text message program (Wellness4Teachers) would be effective in reducing stress, burnout, anxiety, or depression symptoms among teachers.

Objective
The goal of this study is to evaluate the prevalence and correlates of stress, burnout, symptoms of anxiety, depression, and low resilience among elementary and high school teachers in Alberta and Nova Scotia, Canada. It also aims to determine if daily supportive text messages can help reduce the prevalence of these psychological problems in teachers.

Methods
This is a cross-sessional mixed methods study with data to be collected from subscribers of Wellness4Teachers using a web-based survey at baseline (onset of text messaging), 6 weeks, the program’s midpoint (3 months), and end point (6 months). Teachers can subscribe to the Wellness4Teachers program by texting the keyword “TeachWell” to the program phone number. Outcome measures will be assessed using standardized rating scales and key informant interviews. Data will be analyzed with descriptive and inferential statistics using SPSS and thematic analysis using NVivo.

Results
The results of this study are expected 24 months after program launch. It is expected that the prevalence of stress, burnout, anxiety, depression, and low resilience among teachers in Alberta and Nova Scotia would be comparable to those reported in other jurisdictions. It is also expected that factors such as gender, number of years teaching, grade of teaching, and school type (elementary vs high school) will have an association with burnout and other psychological disorders among teachers. Furthermore, it is expected that Wellness4Teachers will reduce the prevalence and severity of psychological problems in teachers, and subscriber satisfaction will be high.

Conclusions
The Wellness4Teachers project will provide key information regarding prevalence and correlates of common mental health conditions in teachers in Alberta and Nova Scotia, as well as the impact of daily supportive text messages on these mental health parameters. Information from this study will be useful for informing policy and decision-making concerning psychological interventions for schoolteachers.
Hubungan Tingkat Stres dengan Kualitas Tidur pada Mahasiswa Tingkat Akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi
Authors: Clariska Windi , Yuliana Yuliana , Kamariyah Kamariyah 
Published: June 2022

Internal and external obstacles that occur in final year students can cause students to be depressed and stressed and have an impact on the quality of their sleep. The results of the preliminary survey on 23 students found it difficult to rest since their thesis writing. WHO data for 2019, nearly 264 million people in the world experience stress and depression. To determine the relationship between stress levels and sleep quality in final year students at the Faculty of Medicine and Health Sciences, Jambi University. This research is a quantitative descriptive study on 92 samples of final year students at the Faculty of Medicine and Health Sciences, Jambi University using the method cluster random sampling. This study uses primary data obtained from questionnaires and data analysis using the Spearman rank test with p value = 0.05. 23 respondents (25%) experienced mild stress, 21 respondents (22.8%) moderate stress, 22 respondents (23.9%) severe stress and 5 very severe stress (5.4%). Poor sleep quality amounted to 84 respondents (91.3%) while good amounted to 8 respondents (8.7%). From the results of the Spearman Rank analysis, it was obtained a p-value of 0.030 with a closeness of the relationship of 0.227. There is a significant relationship between stress levels and sleep quality in final year students at the Faculty of Medicine and Health Sciences, Jambi University.
Keywords: stress, sleep quality, student.

Abstrak
Hambatan internal dan eksternal yang terjadi pada mahasiswa tingkat akhir dapat menyebabkan mahasiswa tertekan dan stres serta berakibat pada kualitas tidurnya. Hasil survey pendahuluan pada 23 mahasiswa, merasa sulit beristirahat semenjak menjalani pembuatan skripsi. Data WHO tahun 2019 hampir 264 juta penduduk dunia mengalami stres dan depresi. Tujuan dari penelitian ini adalah mengetahui hubungan tingkat stres dengan kualitas tidur pada Mahasiswa tingkat akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi. Penelitian ini merupakan penelitian deskriptif kuantitatif pada 92 sampel mahasiswa tingkat akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi dengan metode cluster random sampling. Penelitian ini menggunakan data primer yang diperoleh dari kuesioner dan analisa data menggunakan uji spearman rank dengan p-value = 0,05. Didapatkan mahasiswa yang mengalami tingkat stres ringan 23 responden (25%), stres sedang 21 responden (22,8%), stres berat 22 responden (23,9%) dan stres sangat berat 5 responden (5,4%). Kualitas tidur buruk berjumlah 84 responden (91,3%) sedangkan baik berjumlah 8 responden (8,7%). Dari hasil analisis Spearman Rank didapatkan p-value 0,030 dengan keeratan hubungan 0,227. Terdapat hubungan yang bermakna antara tingkat stres dengan kualitas tidur pada mahasiswa tingkat akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi.
Kata Kunci: Stres, Kualitas tidur, Mahasiswa.
Gambaran Tingkat Pendidikan dan Tinggi Badan Orangtua Balita Stunting Usia 24-59 Bulan
Authors: Putri Nelvi , Nurlinawati Nurlinawati , Mawarti Indah 
Published: June 2022

Stunting has a large impact on the growth and development of children and also the economy of Indonesia in the future. Stunted toddlers will generally experience obstacles in cognitive and motor development and also have a greater risk for suffering from non- communicable diseases such as diabetes, obesity, and heart disease in adulthood. Parent's level of education and height are the main determinants of stunting. Therefore, the researcher wants to see an overview of the level of education and stunting of parents of stunting toddlers aged 24-59 months in the working area of the Puskesmas Siulak Mukai, Kerinci Regency. This type of research is descriptive research. In determining the number of samples in this study using a total sampling technique that is all parents who have stunting toddlers aged 24-59 months in the working area of the Puskesmas Siulak Mukai Kabupaten Kerinci used as samples with a total sample of 42 stunting toddlers, sampling using the purposive sampling method. Analysis of the data used in this study is univariate analysis. The results showed that the level of education of high school fathers / equivalent was 42.9%, the level of education of high school / fathers as much as 40.5%, father's height was 55% more than the height of short fathers by 45%, high short maternal body as much as 59.5%. The level of education of parents of high school / equivalent and low maternal height can cause children to grow stunting.
Continuous glucose monitoring metrics and birthweight: informing management of type 1 diabetes throughout pregnancy
Authors: Scott Eleanor M , Murphy Helen R , Kristensen Karl H , Feig Denice S , Kjölhede Karin , Englund-Ögge Linda , Berntorp Kerstin E , Law Graham R 
Published: June 2022

<p> </p>
<p><strong>Objective: </strong>To determine gestational weekly changes in continuous glucose monitoring<strong> (</strong>CGM) metrics and 24hr glucose profiles, and their relationship to infant birthweight in pregnant women with type 1 diabetes.</p>
<p><strong>Research Design and Methods: </strong>An analysis of >10.5 million CGM glucose measures from 386 pregnant women with type 1 diabetes, from two international, multicentre studies. CGM glucose metrics and 24hr glucose profiles were calculated for each gestational week and the relationship to normal (10-90th percentile) and large (>90th percentile) for gestational age (LGA) birthweight infants determined. </p>
<p><strong>Results: </strong>Mean CGM glucose concentration fell and percentage of time spent in the pregnancy target range 3.5-7.8 mmol/L (63-140mg/dL) increased in the first 10 weeks of pregnancy, plateaued until 28 weeks gestation, before further improvements in mean glucose and percentage time-in-range until delivery. The maternal CGM glucose metrics diverged at 10 weeks gestation, with significantly lower mean CGM glucose concentration (7.1mmol/L 95% CI 7.05-7.15 [127.8mg/dL 95% CI 126.9-128.7] vs.7.5mmol/L 95% CI 7.45-7.55 [135mg/dL 95% CI 134.1-135.9]) and higher percentage time-in-range (55% [95% CI 54-56] vs.50% [95% CI 49-51]) in women who had normal versus LGA. The 24hr glucose profiles were significantly higher across the day from 10 weeks gestation in LGA.</p>
<p><strong>Conclusion:</strong> Normal birthweight is associated with achieving a significantly lower mean CGM glucose concentration across the 24-hour day and higher CGM time-in-range from before the end of the first trimester, emphasizing the need for a shift in clinical management, with increased focus on using weekly CGM glucose targets for optimising maternal glycemia from early pregnancy.</p>