bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facial expression recognition is linked to clinical and neurofunctional differences in autism
Authors: Meyer-Lindenberg Hannah , Moessnang Carolin , Oakley Bethany , Ahmad Jumana , Mason Luke , Jones Emily J. H. , Hayward Hannah L. , Cooke Jennifer , Crawley Daisy , Holt Rosemary , Tillmann Julian , Charman Tony , Baron-Cohen Simon , Banaschewski Tobias , Beckmann Christian , Tost Heike , Meyer-Lindenberg Andreas , Buitelaar Jan K. , Murphy Declan G. , Brammer Michael J. , Loth Eva 
Published: November 2022

Abstract
Background
Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses.

Methods
Between 255 and 488 participants aged 6–30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task.

Results
We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup.

Limitations
Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication.

Conclusions
We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals.
On some new generalized fractional Bullen-type inequalities with applications
Authors: Hussain Sabir , Rafeeq Sobia , Chu Yu-Ming , Khalid Saba , Saleem Sahar 
Published: November 2022

AbstractIn this paper, we establish a Bullen-type generalized fractional integral identity for the differentiable functions and derive some new estimates for the Bullen-type fractional integral inequalities via the Raina fractional integrals. Further examples are given to indicate the validity of obtained results. Lastly, some error estimates for the quadrature rules are provided, and to find applications for our results to information theory, we proved a new generalization based on f-divergence measure.
COVID-19 and aerobic exercise: possible role of angiotensin converting enzyme 2
Authors: Djemai Haidar , Hammad Rami , Dabayebeh Ibrahim M. , Hammad Saleh , Merzouk Abdellah , Coumoul Xavier , Noirez Philippe 
Published: November 2022

AbstractThe emergence and circulation of a novel coronavirus (2019-nCoV)—Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—set off a global health crisis. SARS-CoV-2 spreads faster than its two ancestors, SARS-CoV and MERS-CoV. Several modes of transmission have been identified: via respiratory droplets, contact with infected people or contaminated surfaces, and potentially, bioaerosols. Various countries have taken preventive measures that may include partial or total lockdowns lasting weeks. The physical inactivity associated with lockdowns may promote cardiometabolic or other diseases, while physical activity may play a critical role in preventing them. Here we develop the hypothesis of the involvement of aerosols in the contamination process, the role of angiotensin converting enzyme 2 (ACE2), the potential benefits and harm of physical activity during lockdowns, and we suggest directions for future research.
Determinants of change in unintended pregnancy in Ethiopia using the 2005 and 2016 EDHS: non-linear multivariable decomposition analysis
Authors: Tareke Abiyu Abadi , Enyew Ermias Bekele , Dubale Abiy Tasew , Shimie Aynadis Worku , Kasaye Mulugeta Desalegn , Eshetu Habitu Birhan 
Published: November 2022

Abstract
Background
Unintended pregnancy is a pregnancy either mistimed or unwanted. The main consequence of unintended pregnancy is inducing abortion. In Ethiopia, more than half of unintended pregnancies end up in abortion.

Objective
This study aims to measure the change in unintended pregnancy among women of reproductive age between survey years 2005 and 2016 and to identify the socio-demographic factors that most significantly contributed to the change.

Methods
Data from the two most recent Ethiopian Demographic and Health Surveys (EDHS) were analyzed. We quantified the contribution of socio-demographic factors in the change of unintended pregnancy, using Oaxaca-Blinder decomposition for non-linear regression models by applying the STATA command ‘mvdcmp’.

Result
Unintended pregnancy decreased from 37% in 2005 to 27% in 2016 in Ethiopia. Both changes in population characteristics and coefficient were the contributing elements to the observed change in unintended pregnancy. Among population characteristics factors, being a partial decision-maker and being a slum in the Somali region contributed 10 and 14% to the change of unintended pregnancy between the 2005 and 2016. Of the coefficient factors, knowledge of modern family planning, being a partial decision-maker, media exposure, distance to health facilities, and health facility visits contributed to the change by 93, 43, 17, and 10% respectively.

Conclusion
The majority of the change in unintended pregnancy from 2005 to 2016 survey was due to differences in coefficients (85%). The principal contributing factors to the change of unintended pregnancy were FP knowledge, decision making, media exposure and health facility visits. Therefore, an interventional plan will be efficient, better, and more effective if focused on the larger contributing factors.
Temperature-dependent modal analysis of the InSight lander on Mars
Authors: Zhang Lei , Gao Fei , Liu Zai , Cao Peng , Zhang Jinhai 
Published: November 2022

The first high-performance seismometer on Mars, deployed by InSight, has been working for nearly two Martian years. However, the recorded seismic data are substantially affected by the natural frequencies of the lander. To analyze the effect of the natural frequencies of the lander on specific components of the seismic data, we have built a simplified finite-element model of the lander to conduct modal analyses. Three natural frequencies are modeled by comparing them with those identified from the observed data. These natural frequencies are nonconstant and temperature dependent, which can be explained as an elastic modulus reduction of the solar panels (35% at most) and/or the property changes of the ground media beneath the lander due to a daily air temperature variation of approximately 100 K on Mars. Compared with the previous studies based on the empirical models before the launch, our results can quantitatively evaluate natural modes and their temperature dependency. Thus, these analyses are helpful in avoiding the potential interference of natural frequencies and improving the reliability of seismic data applications.
Medicare Advantage: A Disadvantage for Complex Cancer Surgery Patients
Authors: Raoof Mustafa , Ituarte Philip H.G. , Haye Sidra , Jacobson Gretchen , Sullivan Kevin M. , Eng Oliver , Kim Jae , Fong Yuman 
Published: November 2022

PURPOSENearly half of all Medicare beneficiaries are enrolled in privatized Medicare insurance plans (Medicare Advantage [MA]). Little comparative information is available about access, outcomes, and cost of inpatient cancer surgery between MA and Traditional Medicare (TM) beneficiaries. We set out to assess and compare access, postoperative outcomes, and estimated cost of inpatient cancer surgery among MA and TM beneficiaries.METHODSRetrospective cohort analysis of MA or TM beneficiaries undergoing elective inpatient cancer surgery (for cancers located in lung, esophagus, stomach, pancreas, liver, colon, or rectum) was performed using the Office of Statewide Health Planning Inpatient Database linked to California Cancer Registry from 2000 to 2020. For each cancer site, risk-standardized access to high-volume hospitals, postoperative 30-day mortality, complications, failure to rescue, and surgery-specific estimated costs were compared between MA and TM beneficiaries.RESULTSThis analysis of 76,655 Medicare beneficiaries (median age 74 years, 51% female, 39% MA) included 31,913 colectomies, 10,358 proctectomies, 4,604 hepatectomies, 2,895 pancreatectomies, 3,639 gastrectomies, 1,555 esophagectomies, and 21,691 lung resections. Except for colon surgery, MA beneficiaries were less likely to receive care at a high-volume hospital. Mortality was significantly higher among MA beneficiaries ( v TM) for gastrectomy (adjusted risk difference [ARD], 1.5%; 95% CI, 0.01 to 2.9; P = .036), pancreatectomy (ARD, 2.0%; CI, 0.80 to 3.3; P = .002), and hepatectomy (ARD, 1.4%; 95% CI, 0.1 to 2.9; P = .04). By contrast, compared with TM, MA beneficiaries incurred lower estimated hospital costs.CONCLUSIONEnrollment in MA plan is associated with lower estimated hospital costs. However, compared with TM, MA beneficiaries had lower access to high-volume hospitals and increased 30-day mortality for stomach, pancreas, or liver surgery.
Making Every Meeting Count: A Qualitative Investigation of Multiteam Meeting Events and Their Role in Supporting Coordinated Cancer Care Delivery
Authors: Wolf Annamaria V. , Hedrick Katelyn N. , Begerowski Sydney R. , Wiper Donald W. , Carter Dorothy R. , Shuffler Marissa L. 
Published: November 2022

PURPOSE: This research considers how cross-disciplinary cancer care meetings can facilitate coordination within the multiteam systems (MTSs) that provide inpatient hospital care. We conducted a series of interviews and observations with members of a single cancer care MTS to address the following research questions: (1) what are the key characteristics of MTS cancer care meetings (with regard to composition, focus, and structure)? and (2) how is cross-team coordination acknowledged and addressed during these meetings? METHODS: In this single-site case study of a MTS operating to provide gynecologic oncology care within a teaching hospital, two types of meetings, called rounds and huddles, were held consistently. We used qualitative methods, including interviews with health care professional subject matter experts and 30 hours of observations of cancer care meetings, and analyzed the data in three stages of qualitative coding. RESULTS: Our analyses resulted in a thematic framework detailing key processes, and subprocesses, identified as central to the activities of observed cancer care meetings. Key processes include information sharing, gaining clarity, strategizing, and pedagogy. Discussions and explanations of this framework showcase the ways in which MTS meetings can bolster cross-team coordination and facilitate MTS activities. CONCLUSION: Inpatient cancer care meetings provide opportunities to facilitate MTS coordination in several ways, yet doing so does not come without challenges. Considering these results together with insights from meeting science and MTS research, this article concludes by putting forward practical recommendations for leveraging opportunities and overcoming challenges to use cancer care meetings as tools to support cross-team coordination.
The HACKD Score—Predicting Extent of Resection of Pituitary Macroadenomas Through an Endoscopic Endonasal Transsphenoidal Approach
Authors: Castle-Kirszbaum Mendel , Wang Yi Yuen , King James , Kam Jeremy , Goldschlager Tony 
Published: November 2022

BACKGROUND:
Predicting extent of resection before pituitary surgery is imperative for operative planning and patient counseling. In the era of endoscopic endonasal transsphenoidal surgery (EEA), a specific, reliable tool for predicting resection of macroadenomas would have widespread applications.

OBJECTIVE:
To identify factors that predict resection of pituitary macroadenomas through the EEA.

METHODS:
A prospectively maintained, multicenter database of 277 consecutive macroadenomas resected through the EEA was analyzed. Multivariate logistic regression identified predictors of gross total resection (GTR). A simple scoring system, the Hardy, Age, Clival, Knosp, Depth (HACKD) Score, was developed and tested.

RESULTS:
GTR was achieved in 82.3% (228/277) of cases. Older than 50 years (odds ratio [OR] 2.96, P = .01), clival extension (OR 5.87, P < .01), Hardy grade C or D suprasellar extension (OR 3.91, P = .01), Knosp grade 3 or 4 cavernous sinus invasion (OR 7.62, P < .01), and tumor depth >20 mm (OR 5.14, P < .01) were all associated with subtotal resection. The HACKD score, awarding 1 point each for Hardy grade C or D, and older than 50 years, and 2 points each for clival extension, Knosp grades 3 or 4, and tumor depth >20 mm, demonstrated excellent discriminative ability (AUROC 0.887, 95% CI: 0.839-0.934). The rate of GTR progressively decreased with a higher HACKD score. Rates of GTR were 95.8% (182/190) for low (HACKD ≤2), 59.5% (44/74) for moderate (HACKD 3-5), and 15.4% (2/13) for high (HACKD 6+) HACKD scores.

CONCLUSION:
The HACKD score is a simple and accurate tool based on the largest study analyzing predictors of GTR in pituitary macroadenomas operated through the EEA.
A method for stabilising the XX karyotype in female mESC cultures
Authors: Keniry Andrew , Jansz Natasha , Hickey Peter F. , Breslin Kelsey A. , Iminitoff Megan , Beck Tamara , Gouil Quentin , Ritchie Matthew E. , Blewitt Marnie E. 
Published: November 2022

ABSTRACT
Female mouse embryonic stem cells (mESCs) present differently from male mESCs in several fundamental ways; however, complications with their in vitro culture have resulted in an under-representation of female mESCs in the literature. Recent studies show that the second X chromosome in female, and more specifically the transcriptional activity from both of these chromosomes due to absent X chromosome inactivation, sets female and male mESCs apart. To avoid this undesirable state, female mESCs in culture preferentially adopt an XO karyotype, with this adaption leading to loss of their unique properties in favour of a state that is near indistinguishable from male mESCs. If female pluripotency is to be studied effectively in this system, it is crucial that high-quality cultures of XX mESCs are available. Here, we report a method for better maintaining XX female mESCs in culture that also stabilises the male karyotype and makes study of female-specific pluripotency more feasible.
Prognostication of overall survival in patients with brain metastases using diffusion tensor imaging and dynamic susceptibility contrast-enhanced MRI
Authors: de Godoy Laiz Laura , Chen Yin Jie , Chawla Sanjeev , Viaene Angela N , Wang Sumei , Loevner Laurie A , Alonso-Basanta Michelle , Poptani Harish , Mohan Suyash 
Published: November 2022

Objectives:To investigate the prognostic utility of DTI and DSC-PWI perfusion-derived parameters in brain metastases patients.Methods:Retrospective analyses of DTI-derived parameters (MD, FA, CL, CP, and CS) and DSC-perfusion PWI-derived rCBVmaxfrom 101 patients diagnosed with brain metastases prior to treatment were performed. Using semi-automated segmentation, DTI metrics and rCBVmaxwere quantified from enhancing areas of the dominant metastatic lesion. For each metric, patients were classified as short- and long-term survivors based on analysis of the best coefficient for each parameter and percentile to separate the groups. Kaplan-Meier analysis was used to compare mOS between these groups. Multivariate survival analysis was subsequently conducted. A correlative histopathologic analysis was performed in a subcohort (n = 10) with DTI metrics and rCBVmaxon opposite ends of the spectrum.Results:Significant differences in mOS were observed for MDmin(p < 0.05), FA (p < 0.01), CL (p < 0.05), and CP (p < 0.01) and trend toward significance for rCBVmax(p = 0.07) between the two risk groups, in the univariate analysis. On multivariate analysis, the best predictive survival model was comprised of MDmin(p = 0.05), rCBVmax(p < 0.05), RPA (p < 0.0001), and number of lesions (p = 0.07). On histopathology, metastatic tumors showed significant differences in the amount of stroma depending on the combination of DTI metrics and rCBVmax values. Patients with high stromal content demonstrated poorer mOS.Conclusion:Pretreatment DTI-derived parameters, notably MDminand rCBVmax, are promising imaging markers for prognostication of OS in patients with brain metastases. Stromal cellularity may be a contributing factor to these differences.Advances in knowledge:The correlation of DTI-derived metrics and perfusion MRI with patient outcomes has not been investigated in patients with treatment naïve brain metastasis. DTI and DSC-PWI can aid in therapeutic decision-making by providing additional clinical guidance.
Stereotactic prostate radiotherapy with or without androgen deprivation therapy, study protocol for a phase III, multi-institutional randomized-controlled trial
Authors: Bonù Marco Lorenzo , Magli Alessandro , Tomasini Davide , Frassine Francesco , Albano Domenico , Arcangeli Stefano , Bruni Alessio , Ciccarelli Stefano , De Angeli Martina , Francolini Giulio , Franzese Ciro , Ghirardelli Paolo , Grazioli Luigi , Guerini Andrea , Lancia Andrea , Marvaso Giulia , Sepulcri Matteo , Trodella Luca Eolo , Morelli Vittorio , Georgopulos Andrea , Domina Anastasiya Oleksandrivna , Granello Lorenzo , Mataj Eneida , Barbera Fernando , Triggiani Luca 
Published: November 2022

Objective: The therapeutic landscape for localized prostate cancer (PC) is evolving. Stereotactic radiotherapy (SRT) has been reported to be at least not inferior to standard radiotherapy, but the effect of androgen deprivation therapy (ADT) in this setting is still unknown and its use is left to clinical judgment. There is therefore the need to clarify the role of ADT in association with SRT, which is the aim of the present study. Methods: We present a study protocol for a randomized, multi-institutional, Phase III clinical trial, designed to study SRT in unfavorable intermediate and a subclass of high-risk localized PC. Patients (pts) will be randomized 1:1 to SRT + ADT or SRT alone. SRT will consists in 36.25 Gy in 5 fractions, ADT will be a single administration of Triptorelin 22.5 mg concurrent to SRT. Primary end point will be biochemical disease-free survival. Secondary end points will be disease-free survival, freedom from local recurrence, freedom from regional recurrence, freedom from distant metastasis and overall survival (OS); quality of life QoL and patient reported outcomes will be an exploratory end point and will be scored with EPIC-26, EORTC PR 25, IPSS, IIEF questionnaires in SRT + ADT and SRT alone arms. Moreover, clinician reported acute and late toxicity, assessed with CTCAE v. 5.0 scales will be safety end points. Results: Sample size is estimated of 310 pts. For acute toxicity and quality of life results are awaited after 6 months since last patient in, whereas, for efficacy end points and late toxicity mature results will be available 3–5 years after last patient in. Conclusion: Evidence is insufficient to guide decision making concerning ADT administration in the new scenario of prostate ultra-hypofractionation. Hence, the need to investigate the ADT role in SRT specific setting. Advances in knowledge: The stereotactic prostate radiotherapy with or without ADT trial (SPA Trial) has been designed to establish a new standard of care for SRT in localized unfavorable intermediate and a subclass of localized high risk PC.
Cartografias Clínicas: a produção de narrativas como dispositivo de formação no campo da Psicologia Social e Institucional
Authors: Amador Fernanda Spanier , Gaspary Jaime Carlos Vidarte , Gomes Manoela Guimarães , Vechia Thomaz Chaves Della , Santos Vanessa Felix dos 
Published: November 2022

Este artigo apresenta elementos relativos à experimentação da escrita daquilo que chamamos Cartografias Clínicas no escopo da disciplina de Práticas Analítico-Institucionais do curso de Psicologia da Universidade Federal do Rio Grande do Sul. São apresentados trechos de escritas produzidas pelos alunos e alunas a partir de situações experienciadas em seus estágios de ênfase em Psicologia Social e Políticas Públicas como um exercício analítico clínico-institucional dos processos de subjetivação envolvidos, incluindo-se nos seus próprios campos de intervenção, possibilitando a reflexão sobre a “feitura de si” enquanto estagiários e estagiárias em ato. Discute-se a respeito de Clínica, Processos Institucionais, Cartografia e Narratividade.
Mobile phone-based postnatal follow up and maternal health outcomes for low risk mothers
Authors: Ghani Rania Mahmoud Abdel , Khalaf Atika 
Published: November 2022

Background/Aim The immediate postnatal period poses challenges for maternal and newborn health. This study aimed to evaluate the effects of mobile phone-based postnatal follow up on maternal health outcomes among low risk mothers. Methods A quasi-experimental design was used to gather data from 70 mothers at a hospital in Egypt. Participants in the study group received information about postnatal self-care and three postnatal phone calls on day 3 (48–72 hours postpartum), between days 7 and 14 and 6 weeks after birth. Participants in the control group received standard care. Results Significantly more mothers in the study group were lactating (P=0.01), exercising (P<0.001) and rated their health as very good (P=0.03) than in the control group. Furthermore, more mothers in the control group experienced breast engorgement (P=0.01) and constipation (P=0.002), and 40% were not using contraceptive methods at the end of the puerperium period. Conclusions The authors recommend healthcare providers use modern technologies to complement existing care strategies to improve maternal health and reduce risks in a cost-effective way.