bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meridional Location and Profile of a Prematurely Separated WBC Extension Jet in a Two-Layer System
Authors: Kubokawa Atsushi 
Published: December 2022

Abstract
Western boundary currents (WBCs) under no-slip boundary conditions tend to separate from the coast prematurely (without reaching the intergyre boundary) and form eastward jets. This study theoretically considers the meridional structure and location of a prematurely separated WBC extension jet using a two-layer quasigeostrophic model. Assuming homogenized potential vorticity (PV) regions on both sides of and below the jet, we constructed a simple model for the meridional profiles of the zonal flows in the western subtropical gyre. This work clarifies that the meridional structure can be determined if two variables, such as the strength of the PV front (difference in PV across the jet) and the value of the streamfunction at the jet’s center, are given in addition to the meridional profile of the Sverdrup zonal flow and the vertical stratification. The zonal velocity profiles in both layers agreed well with those obtained by numerical experiments. When the jet is close to the intergyre boundary, the meridional location of the jet depends only on the front’s strength. When the northern recirculation gyre is detached from the intergyre boundary and the local wind effect on the jet is negligible, comparisons with the numerical experiments suggest that the jet’s central streamline connects to the central streamline of the eastward Sverdrup flow. We also found that a downward Ekman pumping velocity shifts the jet southward.
Intense Surface Winds from Gravity Wave Breaking in Simulations of a Destructive Macroburst
Authors: Schumacher Russ S. , Childs Samuel J. , Adams-Selin Rebecca D. 
Published: December 2022

Abstract
Shortly after 0600 UTC (midnight local time) 9 June 2020, a convective line produced severe winds across parts of northeast Colorado that caused extensive damage, especially in the town of Akron. High-resolution observations showed gusts exceeding 50 m s−1, accompanied by extremely large pressure fluctuations, including a 5-hPa pressure surge in 19 s immediately following the strongest winds and a 15-hPa pressure drop in the following 3 min. Numerical simulations of this event (using the WRF Model) and with horizontally homogeneous initial conditions (using Cloud Model 1) reveal that the severe winds in this event were associated with gravity wave dynamics. In a very stable postfrontal environment, elevated convection initiated and led to a long-lived gravity wave. Strong low-level vertical wind shear supported the amplification and eventual breaking of this wave, resulting in at least two sequential strong downbursts. This wave-breaking mechanism is different from the usual downburst mechanism associated with negative buoyancy resulting from latent cooling. The model output reproduces key features of the high-resolution observations, including similar convective structures, large temperature and pressure fluctuations, and intense near-surface wind speeds. The findings of this study reveal a series of previously unexplored mesoscale and storm-scale processes that can result in destructive winds.

Significance Statement
Downbursts of intense wind can produce significant damage, as was the case on 9 June 2020 in Akron, Colorado. Past research on downbursts has shown that they occur when raindrops, graupel, and hail in thunderstorms evaporate and melt, cooling the air and causing it to sink rapidly. In this research, we used numerical models of the atmosphere, along with high-resolution observations, to show that the Akron downburst was different. Unlike typical lines of thunderstorms, those responsible for the Akron macroburst produced a wave in the atmosphere, which broke, resulting in rapidly sinking air and severe surface winds.
Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial
Authors: Bastien Gabriel , McAnulty Christina , Ledjiar Omar , Socias M. Eugenia , Le Foll Bernard , Lim Ron , Hassan Ahmed N. , Brissette Suzanne , Marsan Stéphanie , Talbot Annie , Jutras-Aswad Didier ,   for the OPTIMA Research Group within the Canadian Research Initiative in Substance Misuse
Published: December 2022

Objective This study aimed to evaluate the effectiveness of flexible take-home dosing of buprenorphine/naloxone (BUP/NX) and methadone standard model of care in reducing depressive symptoms in people with prescription-type opioid use disorder (POUD). This trial also evaluated whether improvements in depressive symptoms were mediated by opioid use. Methods Analyzed data came from the OPTIMA study (clinicaltrials.gov identifier: NCT03033732), a pragmatic randomised controlled trial comparing flexible take-home dosing of BUP/NX and methadone standard model of care for reducing opioid use in people with POUD. A total of 272 participants were recruited in four Canadian provinces. Participants were randomised 1:1 to BUP/NX or methadone. After treatment induction, past two-week opioid use was measured using the Timeline Followback every two weeks for a total of 24 weeks. Depressive symptoms were measured with the Beck Depression Inventory at baseline, weeks 12 and 24. Results Both BUP/NX and methadone significantly reduced depressive symptoms at week 12 (aβ ± SE = −3.167 ± 1.233; P < 0.001) and week 24 (aβ ± SE = −7.280 ± 1.285; P < 0.001), with no interaction between type of treatment and time ( P = 0.284). Improvements in depressive symptoms were only partially mediated by a reduction in opioid use (proportion mediated = 36.8%; 95% confidence interval = −1.158 to −0.070; P = 0.015). Conclusions BUP/NX and methadone showed similar effectiveness in decreasing comorbid depressive symptoms in people with POUD. This effect was partially explained by a reduction in opioid use. As both treatments seem equally effective, clinicians are encouraged to tailor the selection of OAT to patients’ needs and characteristics.
The difference in diameter between radial artery and cephalic vein correlates with primary patency of radio-cephalic arteriovenous fistula
Authors: Jiang Ying , Huang Xiaoyan , Shan Ying , Chen Li , Huang Huie , Jiang Lei , Liang Wei 
Published: December 2022

Introduction: Autogenous radio-cephalic arteriovenous fistula (RCAVF) is preferred for chronic hemodialysis access. However, RCAVF still suffers from disappointing survival due to fistula dysfunction, with intimal hyperplasia (IH) as an underlying cause of this condition. The inconsistency of radial artery diameter (DRA) and cephalic vein diameter (DCV) is one of the factors affecting the shear disturbance, which is believed to trigger the onset of IH. However, there are no reports correlating the difference in DRA and DCV with RCAVF outcomes. Methods: This was a retrospective cohort study. Consecutive patients ( n = 233) with a new RCAVF created were included if they underwent duplex ultrasound examination to evaluate preoperatively the radial artery diameter (DRA) and cephalic venous diameter (DCV). We then calculated radial artery-cephalic vein diameter difference (DCV minus DRA, termed DCV-DRA hereafter) and evaluated the association of the preoperative DCV-DRA with primary patency of RCAVF at 12 months. Subgroup analysis was also performed to explore effect modification by age, gender, radial artery diameter, and cephalic vein diameter with DCV-DRA. Results: After adjusting for age, gender, weight, and mean arterial pressure, the preoperative DCV-DRA was associated with primary patency of RCAVF at 12 months (adjusted Odds ratio [aOR], 1.524 per 1-mm increase; 95% confidence interval [95% CI], 1.048–2.218). The primary patency of RCAVF at 12 months was achieved in 69.4%, 71.8%,and 87.3% of patients with a preoperative DCV-DRA of ⩽−0.6 mm, (−0.5)–0.5 mm, and ⩾0.6 mm, respectively. P for trend was 0.029. Patients with DCV-DRA of ⩾0.6 mm had a much higher chance of 12-month patency than patients with DCV-DRA of ⩽−0.6 mm (aOR, 3.574; 95% CI, 1.276–10.010). Age, gender, radial artery diameter, and cephalic vein diameter did not modify the association of DCV-DRA with primary patency of RCAVF at 12 months. Conclusions: Preoperative DCV-DRA may be an under-recognized predictor of RCAVF patency.
How my life is unique: Sibling perspectives of autism
Authors: Burnham Riosa Priscilla , Ensor Rebecca , Jichici Brynn , Davy Brittany 
Published: December 2022

The impact of autism on the family is an area of study that merits further research attention. Much of the existing literature has focused on the parent perspective, with less emphasis on the experiences of other family members, particularly non-autistic siblings. This study aimed to explore the lived experiences of a sample of nine 8- to 17-year-old non-autistic siblings of children and youth on the autism spectrum. We interviewed siblings and analysed transcripts using interpretative phenomenological analysis. Our results revealed the following Group Experiential Themes: (1) Role disparities, different expectations; (2) C onnection and disconnection; and (3) Our family is (extra)ordinary. Our study findings highlight the unique and collective perspectives of siblings regarding their brother or sister on the spectrum within the broader family dynamic. We discuss the implications of these results on siblings of autistic children and youth. Lay abstract The impact of autism on the family is an important area of study. Much of the existing literature has focused on the parent perspective, with less emphasis on the experiences of other family members, especially non-autistic siblings. This study aimed to explore the lived experiences of a sample of nine 8- to 17-year-old non-autistic siblings of children and youth on the autism spectrum. We interviewed non-autistic siblings and analysed the written transcripts. Our results revealed the following themes: (1) Role disparities, different expectations; (2) Connection and disconnection; and (3) Our family is (extra)ordinary. Our study findings highlight siblings’ unique and collective perspectives regarding their brother or sister on the spectrum within the broader family unit. We discuss the implications of these results on siblings of autistic children and youth.
An initial trial of OPT-In-Early: An online training program for caregivers of autistic children
Authors: Dai Yael G , Thomas Rebecca P , Brennan Lynn , Luu My-Linh , Hughes-Lika Jamie , Reilly Molly , Moreno Paula , Obe Brenda , Ahmed Kelli B , Berry Leandra N , Goin-Kochel Robin P , Helt Molly S , Barton Marianne L , Dumont-Mathieu Thyde , Robins Diana L , Fein Deborah A 
Published: December 2022

Online Parent Training in Early Behavioral Intervention (OPT-In-Early) is a self-directed resource for caregivers of autistic children. Sixty-three parent–child dyads from three states in were randomized to the OPT-In-Early or treatment as usual group. Parents in both groups completed baseline and post-treatment visits, which were targeted for 4 months apart but allowed to go up to 6 months. Compared to parents in the treatment as usual group, parents randomized to OPT-In-Early learned more evidence-based intervention principles from baseline to post-treatment and were rated by observers blind to group and time as increasing their use of these strategies during brief semi-structured interactions with their children. Parent participation in OPT-In-Early did not significantly influence children’s social communication as coded from one observation session. Results suggest that parents acquired knowledge and skills in intervention techniques from OPT-In-Early. Longer trials may be needed for gains in child behavior. Lay abstract Early intervention can help children learn language and improve social communication. However, many barriers, including the expense of services and an insufficient number of providers, prohibit families from accessing services when their children are young. We developed a comprehensive online program for caregivers of autistic children. The program, Online Parent Training in Early Behavioral Intervention (OPT-In-Early), uses text and video demonstrations to teach caregivers effective methods for improving their children’s language, social, and adaptive skills (e.g. using utensils, toilet training), and reducing their children’s disruptive behavior. Sixty-three parents from three states participated in the study. Half of the parents received access to the OPT-In-Early program. After 4 months, parents who had access to the OPT-In-Early program learned more effective intervention strategies, and started using these strategies during interactions with their children, than parents who did not receive access to the program. Parent participation in OPT-In-Early did not significantly influence children’s social communication compared to children whose parents did not have access to OPT-In-Early. A longer duration of parents using learned intervention skills with their children may be needed for children’s social communication skills to improve.
The “Worst-Case Scenario”: Recovery Between Repeated High-Intensity Efforts in Rugby League Match-Play
Authors: Gabbett Tim J. 
Published: December 2022

Background: Repeated high-intensity effort (RHIE) activity is known to be a critical component of high-intensity, intermittent team sports. Despite the importance of this quality, there are few studies comparing the RHIE activity of higher- and lower-ranked teams competing in the same competition. This study characterized the distribution of recovery times between RHIE in Top 4 and Bottom 4 semi-elite rugby league players. Hypothesis: Players from Top 4 teams will engage in a greater frequency of RHIE bouts than Bottom 4 teams, with shorter recovery periods between consecutive efforts. Study Design: Cohort study. Methods: A total of 104 semi-elite rugby league players from 11 teams wore global positioning system units during 28 Queensland Cup rugby league matches. Recovery between efforts was classified as <10, 11 to 20, 21 to 30, 31 to 60, and 61 to 120 seconds. Results: The majority of RHIE bouts were performed with ≤10 seconds recovery between efforts for both Top 4 and Bottom 4 teams. Top 4 teams performed a greater proportion of RHIE bouts with ≤10 seconds recovery between efforts than Bottom 4 teams (effect size [ES], 0.27 ± 0.19), while only trivial differences (ES, 0.17 ± 0.20) were found between Top 4 and Bottom 4 teams for the proportion of RHIE with 61 to 120 seconds recovery between efforts. Wide-running forwards from Top 4 teams performed a greater proportion of RHIE bouts with ≤10 seconds recovery between efforts (ES, 0.59 ± 0.40) and a smaller proportion of RHIE bouts with 61 to 120 seconds recovery between efforts (ES, 0.62 ± 0.38) than wide-running forwards from Bottom 4 teams. Conclusion: Rugby league players perform proportionally more RHIE bouts with ≤10 seconds recovery between efforts than any other recovery duration. In addition, Top 4 teams are more likely to complete a greater proportion of short (≤10 seconds) recovery RHIE bouts than Bottom 4 teams. Clinical Relevance: These findings demonstrate the demanding nature of RHIE activity in rugby league. To be successful, teams should train for these demanding passages of play.
A reappraisal of the phylogeny and historical biogeography of Sparganium (Typhaceae) using complete chloroplast genomes
Authors: Zhang Qiaoyu , Belyakov Eugeny A. , Lapirov Alexander G. , Zhao Yixuan , Freeland Joanna , Xu Xinwei 
Published: December 2022

Abstract
Background
Sparganium (Typhaceae) is a widespread temperate genus of ecologically important aquatic plants. Previous reconstructions of the phylogenetic relationships among Sparganium species are incompletely resolved partly because they were based on molecular markers comprising < 7,000 bp. Here, we sequenced and assembled the complete chloroplast genomes from 19 Sparganium samples representing 15 putative species and three putative subspecies in order to explore chloroplast genome evolution in this genus, clarify taxonomic lineages, estimate the divergence times of Sparganium species, and reconstruct aspects of the biogeographic history of the genus.

Results
The 19 chloroplast genomes shared a conserved genome structure, gene content, and gene order. Our phylogenomic analysis presented a well-resolved phylogeny with robust support for most clades. Non-monophyly was revealed in three species: S. erectum, S. eurycarpum, and S. stoloniferum. Divergence time estimates suggest that the two subgenera of Sparganium split from each other ca. 30.67 Ma in the middle Oligocene. The subgenus Xanthosparganium diversified in the late Oligocene and Miocene, while the subgenus Sparganium diversified in the late Pliocene and Pleistocene. Ancestral area reconstruction suggested that the two subgenera may have originated in East Eurasia and North America.

Conclusion
The non-monophyletic nature of three putative species underscores the necessity of taxonomic revision for Sparganium: S. stoloniferum subsp. choui may be more appropriately identified as S. choui, and subspecies of S. erectum may be in fact distinct species. The estimated diversification times of the two subgenera correspond to their species and nucleotide diversities. The likely ancestral area for most of subgenus Xanthosparganium was East Eurasia and North America from where it dispersed into West Eurasia and Australia. Most of subgenus Sparganium likely originated in North America and then dispersed into Eurasia. Our study demonstrates some of the ways in which complete chloroplast genome sequences can provide new insights into the evolution, phylogeny, and biogeography of the genus Sparganium.
Two-dimensional speckle tracking echocardiography help identify breast cancer therapeutics–related cardiac dysfunction
Authors: Liu Wei , Li Wei , Li Hairu , Li Ziyao , Zhao Peng , Guo Zihong , Liu Cong , Sun Litao , Wang Zhenzhen 
Published: December 2022

Abstract
Background
Cancer therapeutics–related cardiac dysfunction (CTRCD) from different chemotherapy strategies are underdetermined by echocardiography. As an imaging marker of subclinical cardiac dysfunction, two-dimensional speckle tracking echocardiography (2D-STE) may assist in identifying the impact patterns of different CTRCD.

Methods
A total of 67 consecutive patients with invasive ductal breast carcinoma who will undertake neoadjuvant chemotherapy were enrolled and grouped according to their different chemotherapy regimens based on their biopsy results. Group A included 34 patients who received anthracycline without trastuzumab, whereas Group B had 33 patients who received trastuzumab without anthracycline. Echocardiography was performed at three time-points, i.e., baseline (T0), cycle-2 (T2), and cycle-4 (T4) of chemotherapy. Conventional echocardiographic measurements and 2D-STE strain values, and myocardial work (MW) parameters, were compared between different groups at different time-points.

Results
The mean age had no statistical difference between the two groups. E/e′ was the only conventional echocardiographic parameter that had variation in group A (P < 0.05). Compared with baseline, GLS in group A decreased at T2, and GCS decreased at T4 (P < 0.05). GLS and GCS in group B both decreased at T4 (P < 0.05). More patients in group A had a more than 15% fall of baseline GLS rather than GCS at T2 (P < 0.05), however, there was no difference of either GLS or GCS decline rate at T4 between the two groups. All the MW parameters in group A had variations overtime, whereas only GCW in group B (P < 0.05).

Conclusion
Early subclinical myocardial dysfunction can be identified by 2D-STE in breast cancer patients with chemotherapy, and GLS provides profound value in demonstrating the temporal changes in early myocardial damage induced by anthracycline. LV contractility injury in patients with trastuzumab may be mild at first but increases in severity with exposure time as early as cycle-4. Awareness of these differences may help to stratify the prevention of late cardiovascular events caused by different CTRCDs. In addition, GCW may be the most sensitive myocardial work parameter of CTRCD.
Seizure from water intoxication following bowel preparation: a case report
Authors: Chiang Ting-Hsuan , Tan Jui-Hsiang , Chang Chun-Chao , Fang Kuan-Chieh 
Published: December 2022

Abstract
Background
Bowel preparation prior to colonoscopic examination is generally considered a safe process. Hyponatremia is a complication that has been reported in literature during bowel preparation. Individuals who develop severe symptomatic hyponatremia are often older and have comorbidities such as hypothyroidism, chronic kidney disease, or adrenal insufficiency. However, other mechanisms and circumstances can also lead to this potentially fatal complication.

Case presentation
We present a unique case of a patient who developed seizure prior to colonoscopy due to acute hyponatremia without any well-known risk factors. With the subsequent diagnosis of water intoxication, the use of desmopressin was believed to have contributed to this serious complication.

Conclusion
In addition to the use of certain well-documented medications and the presence of comorbidities that can lead to hyponatremia, clinicians should also be aware of the use of desmopressin as an important risk factor. Thorough history taking can guide individualized bowel preparation regimens to minimize the risk of undesired complications.
Comparison of clinical effects between early follicular prolonged GnRH agonist protocol and GnRH antagonist protocol in 3310 cycles: a retrospective study
Authors: Gui Juan , Ni Yuan , Liu Qian , Wang Xiaochen , Xie Qingzhen 
Published: December 2022

Abstract
Background
It is the duty of doctors to choose a safe, simple, economic and effective controlled ovulation stimulation (COS) protocol for the patients. This study aims to compare the clinical effects of the early follicular prolonged GnRH agonist (EFPL) and GnRH antagonist (GnRH-Ant) protocols, hoping to provide some reference for clinicians when choosing COS program.

Methods
A retrospective study included 3310 ovum pick up cycles undergoing assisted reproductive technology during January 2019 to May 2022 in Renmin Hospital of Wuhan University. Propensity Score Matching (PSM) and multivariable logistic regression analysis were used to improve the comparability between the two protocols. Subgroups were divided according to age, body mass index (BMI) and anti-Mullerian hormone (AMH). The live birth rate (LBR) and clinical pregnancy rate (CPR) were the primary outcomes.

Results
After PSM, the endometrial thickness, fresh embryo transplantation rate, chemical pregnancy rate, CPR were significantly higher in EFPL group than that in GnRH-Ant group (P < 0.001). The E2, LH, P values on trigger day were significantly lower in EFPL group (P < 0.001). The cycle cancellation rate was significantly reduced in EFPL group (P < 0.001). However, the total amount of Gn and duration of Gn were significantly increased in the EFPL group (P < 0.001). Multivariable logistic regression analysis showed that the LBR was significantly higher in EFPL group after matching [OR (95%CI), 1.86 (1.13, 3.05), P = 0.02], especially for those with age < 35 years [OR (95%CI), 1.95 (1.14, 3.34), P = 0.02], BMI < 24 kg/m2 [OR (95%CI), 2.08 (1.14, 3.80), P = 0.02], AMH levels ≥ 4.5 ng/ml [OR (95%CI), 4.19 (1.53, 11.43), P < 0.01].

Conclusion
EFPL regimen is more suitable to elicit live birth for those young patients with BMI < 24 kg/m2 and AMH ≥ 4.5 ng/ml. However, for patients with decreased ovarian reserve or advanced age, EFPL regimen has no advantage over the GnRH-Ant regimen.