bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obesity Does Not Increase Perioperative Outcomes in Older Patients Undergoing Thoracoscopic Anatomic Lung Cancer Surgery
Authors: Tong Chaoyang , Li Tingting , Shen Yaofeng , Zhu Hongwei , Zheng Jijian , Wu Jingxiang 
Published: May 2022

ObjectivesTo investigate the relationship between obesity status and perioperative outcomes in elderly patients undergoing thoracoscopic anatomic lung cancer surgery.MethodsFrom January 2016 to December 2018, we performed a monocentric retrospective cohort study among 4164 consecutive patients aged 65 years or older who underwent thoracoscopic anatomic lung cancer surgery at Shanghai Chest Hospital. Two groups were stratified by body mass index (BMI): nonobese (BMI&lt;28kg/m2) and obese status (BMI≥28kg/m2). Using a 1:1 propensity score matching (PSM) analysis to compare perioperative outcomes between two groups.Results4035 older patients were eventually enrolled, with a mean age of 69.8 years (range: 65-87), and 305 patients were eligible for obese status, with a mean BMI of 29.8 ± 1.7kg/m2. Compared with nonobese patients, obese patients were more likely to have higher rates of intraoperative hypoxemia (1.2% vs 3.9%, P=0.001) and new-onset arrhythmia (2.3% vs 4.3%, P=0.034). The difference in intraoperative transfusion and conversion rates and postoperative outcomes regarding pulmonary complications, new-onset arrhythmia, transfusion, length of hospital stay, 30-day readmission and hospitalization costs between two groups were not significant (P&gt;0.05). After a 1:1 PSM analysis, the difference in both intraoperative and postoperative complications among two groups were not significant (P&gt;0.05). In subgroup analysis, patients with BMI≥30kg/m2 had a similar incidence of perioperative complications compared to patients with BMI between 28 and 30 kg/m2 (P&gt;0.05).ConclusionsOur research data support evidence for “obesity paradox” and also contribute the growing body of evidence that obesity in older patients should not exclude candidates for thoracoscopic anatomic lung cancer surgery.
Serum Levels of MicroRNA-371a-3p (M371) Can Predict Absence or Presence of Vital Disease in Residual Masses After Chemotherapy of Metastatic Seminoma
Authors: Dieckmann Klaus-Peter , Klemke Markus , Grobelny Francesca , Radtke Arlo , Dralle-Filiz Inken , Wülfing Christian , Belge Gazanfer 
Published: May 2022

BackgroundRadiological evaluation of postchemotherapy residual masses of metastatic seminoma is characterized by poor diagnostic accuracy. Serum levels of microRNA-371a-3p (M371) involve high specificity and sensitivity for the primary diagnosis of seminoma. We evaluated if M371 levels can indicate the presence of vital disease in postchemotherapy residual masses in patients with metastatic seminoma.MethodsTwenty-three seminoma patients (median age 52 years) with residual masses had posttreatment measurements of serum M371 levels (group A), fourteen of whom had measurements also beforehand. The posttreatment results were compared with the clinical outcome during follow-up. Eleven patients with complete remission after treatment of metastatic seminoma (group B) and 33 men with non-malignant testicular diseases (group C) served as controls. M371 serum levels were measured by quantitative real-time PCR using miR-30b-5p as endogenous control. An evaluation was performed with descriptive statistical methods.ResultsTwenty-two patients of Group A had uneventful follow-up so far, twenty-one of whom had M371 level &lt;5, and one other had a mildly elevated level below relative quantity (RQ) = 10. One patient with a level of RQ = 26.2 rapidly progressed. The median posttreatment M371 level of the non-progressing patients of group A is not significantly different from the median level of the control group with complete remission (B). Before treatment, the median M371 levels in groups A and B were 507.6 and 143.9, respectively. In both groups, significant drops in M371 levels resulted from treatment.ConclusionNormal M371 serum levels at the time of completion of treatment of metastatic seminoma indicate the absence of vital seminoma in residual masses, while elevated levels &gt;RQ = 10 predict the presence of disease. The optimal timing of M371 measurement after chemotherapy and the appropriate cutoff level still need to be determined. Based on the present results, measuring serum M371 levels involves the potential of a novel tool for assessing postchemotherapy residual masses of metastatic seminoma.
A Longitudinal Examination of Alcohol-Related Blackouts as a Predictor of Changes in Learning, Memory, and Executive Function in Adolescents
Authors: Lorkiewicz Sara A. , Baker Fiona C. , Müller-Oehring Eva M. , Haas Amie , Wickham Robert , Sassoon Stephanie A. , Clark Duncan B. , Nooner Kate B. , Tapert Susan F. , Brown Sandra A. , Schulte Tilman 
Published: May 2022

IntroductionIn adolescents, the relationship between alcohol-related blackouts (ARBs) and distinct cognitive changes lasting beyond intoxication is unclear. We examined ARBs as a predictor of persistent changes in the development of learning, memory, and executive function in participants from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.MethodsDescriptive analyses of the NCANDA sample (N = 831, 50.9% female, 12–21 years at baseline) identified ARB patterns within participants with an ARB history (n = 106). Latent growth curve modeling evaluated ARB-related performance changes on four neuropsychological measures across five years, excluding baseline data to reduce the magnitude of practice effects over time (n = 790). Measures included the Penn Conditional Exclusion Test (PCET), Penn Letter N-back Test (PLBT), Penn Facial Memory Test immediate (PFMTi), and delayed (PFMTd) recognition trials, and the Rey Complex Figure Test copy (RCFTc), immediate recall (RCFTi), and delayed recall (RCFTd) trials. Multivariate models were fit for raw accuracy scores from each measure, with ARB history (i.e., presence of past-year ARBs) as the main independent variable. Age, sex, race, socioeconomic status, assessment site, and alcohol use (i.e., past-year frequency) were included as covariates. Interaction effects between ARB history and alcohol use frequency were tested.ResultsBy year five, 16% of participants had experienced at least one ARB (59% of whom reported &gt; 1 ARB and 57% of whom had an ARB lasting &gt; 1 h). After controlling for demographics and alcohol use, ARB history predicted attenuated PFMTd performance growth at year one. Interaction effects between ARB history and alcohol use frequency predicted attenuated PFMTd performance growth at years one and two. ARB history predicted attenuated RCFTi and RCFTd performance growth by year four, but not PCET or PLBT performance over time. By contrast, greater past-year alcohol use predicted attenuated PFMTi and PFMTd performance growth between years two and four in adolescents without an ARB history.ConclusionWe found that ARBs predict distinct, lasting changes in learning and memory for visual information, with results suggesting that the developing brain is vulnerable to ARBs during adolescence and emerging adulthood.
Comparing Temporospatial Performance During Brisk and Self-Paced Walking by Men With Osteomyoplastic Transfemoral Amputation and Controls Using Pressure and Muscle Activation Peak Times
Authors: Shotande Monique O. , Veirs Kimberly P. , Day Jonathan D. , Ertl William J. J. , Fagg Andrew H. , Dionne Carol P. 
Published: May 2022

BackgroundThe aim of osteomyoplastic transfemoral amputation (OTFA) is to produce sustained, robust prosthetic gait performance by residuum reconstructing. A better understanding of residuum-socket interface pressures (RSI) and residuum muscle activation should uniquely reveal gait stability to better inform long-term rehabilitation goals.ObjectivesThe objectives of this study are to characterize RSI pressures and residuum muscle activation in men with OTFA while walking at two speeds and compare temporospatial muscle activation with intact controls.MethodsIn this study, we observed and compared healthy men with OTFA and controls during 2-min gait trials at brisk and self-paced speeds, two visits, and 1 year apart. RSI pressures and hip adductors, hamstrings, and quadriceps activation were recorded for those with OTFA. OTFA temporospatial muscle activation patterns were compared with the controls. Within the extracted strides, heel-strike and toe-off events and EMG activation peak times were characterized and compared. Peak times for pressure and EMG activity were examined in individual muscles and antagonist muscles of residual and intact limbs.ResultsSix men with OTFA exhibited adductor, hamstring, and quadriceps co-contraction within intact and residual limbs, regardless of walking speed or trial. Co-contraction within their intact limb occurred throughout the gait cycle. Within the residuum, co-contraction occurred during weight transference. The 75% most likely RSI peaks occurred during stance. EMG peaks were 75% most likely to occur during early stance, terminal stance-initial swing, and terminal swing.ConclusionParticipants with OTFA demonstrated adductors-hamstrings-quadriceps co-contraction in the intact thigh and residuum with corresponding RSI pressure increase, primarily during transitions between stance and swing, indicating gait instability, demonstrating the need to explicitly address these deficits continuously in rehabilitation and wellness settings.
[D-Ala2, D-Leu5] Enkephalin Attenuates Hepatic Ischemia–Reperfusion Injury in Cirrhotic Rats
Authors: Liu Jueying , Wang Yuan , Pan Qianling , Chen Xueqing , Qu Yifeng , Zhu Hao , Zheng Li , Fan Yinghui 
Published: May 2022

Background and AimsHepatic ischemia–reperfusion injury (IRI) is a common phenomenon that occurs after liver transplantation and liver tumor surgery. It can cause liver dysfunction and recovery failure after liver surgery, even leading to acute liver failure. Our aim is to investigate the protective effect and related potential mechanism of [D-Ala2, D-Leu5] enkephalin (DADLE) treatment on hepatic IRI in cirrhotic livers of rats.MethodsThe models of liver cirrhosis and hepatic IRI were established with male Sprague–Dawley rats. DADLE at a dose series of 0.5, 1, or 5 mg·kg−1 was injected intravenously to rats 10 min prior hepatic ischemia, followed by a 6- h reperfusion. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), histological changes, and liver cell apoptosis were used to assess liver IRI. The optimal dose of DADLE was assessed by using the Suzuki score and ALT and AST levels. We repeated the hepatic IRI procedure on the optimal dose of the DADLE group and the delta opioid receptor (DOR) antagonist natrindole hydrochloride (NTD) injection group. Serum ALT and AST levels, histological staining, hepatic apoptosis, and serum levels of tumor necrosis factor alpha (TNF-α) and interleukin 1 β (IL-1β) were measured. The expression of protein kinase B (Akt) and its downstream proteins were evaluated by using quantitative real-time polymerase chain action (qRT-PCR) and Western blotting.ResultsCompared with the control group, DADLE treatment at a dose of 5 mg·kg−1 reduced the Suzuki score (mean: 5.8, range: 5.0–6.6 vs. mean: 8.0, range: 7.0–8.9), the ALT level (134.3 ± 44.7 vs. 247.8 ± 104.6), and the AST (297.1 ± 112.7 vs. 660.8 ± 104.3) level. DOR antagonist NTD aggravated hepatic IRI. Compared with the control group, DADLE treatment decreased the number of apoptosis cells and microphages and neutrophils, increased the expression of Akt and its mRNA to much higher levels, and upregulated the mRNA and protein expression of Bcl-2 and Bcl-2-associated death promoter (BAD).ConclusionDADLE treatment at a dose of 5 mg·kg−1 injected intravenously 10 min prior hepatic ischemia could contain rats’ hepatic IRI by activating DOR in cirrhotic livers. The effects of DADLE could be offset by NTD. The potential molecular mechanism seems to be involved in the phosphatidylinositol-3-kinase (PI3K)/Akt pathway.
A Research on Sevvel Murugan’s Courage and Thiruseeralaivaai Origin through Paripadal - Based on the Historical Perspective of Human Civilization
Authors: J Valli 
Published: May 2022

Tamil one of the oldest languages ​​in the world. Sangam literatures, the oldest literature available in Tamil, which contains the collection of poems of Eighteen books called Ettuthogai and patthu paattu. Paripaadal was one of the book in Ettuthogai which having poems on Lord Murugan. In Tamilnadu, Lord murugan having six Holy places which called Arupadai veedu. A lot of Tamil literature has sung exclusively about Murugan's Arupadai veedu. Thiru seeralaivaai is one of the holy place of Lord Murugan. The 5 th poem of the Paripaadal, explaining the Sevvel Murugan’s courage and Origin of Thiruseeralaivaai. This article explaining the Sevvel Murugan’s courage and Thiruseeralaivaai Origin, Based on the historical perspective of human civilization through the 5th poem of Paripadal.
Morbimortalidad en pacientes COVID-19 positivo
Authors: Córdova-Molina Eduardo Fabián , Gordillo-Arias Ángel Daniel , Salazar-Acurio Gisselle Paulina , Bonifaz-Díaz Diego Raúl 
Published: May 2022

Objetivo: Descripción de la actualidad de la morbimortalidad de pacientes COVID-19 positivo en el Hospital General Docente “Ambato”, para comprender el comportamiento del virus. Método: Descriptiva observacional y análisis de casos de morbimortalidad de pacientes. Resultados: La mayor prevalencia de casos COVID-19 se encuentra en adultos maduros (40-65 años) con un 48.1% de los casos registrados. Conclusión: La patogenia en pacientes COVID-19; en los registros proporcionados por el Hospital General Docente Ambato, se evidencia que la existencia de alguna comorbilidad de transcurso crónico, sobre todo en patologías cardiovasculares, respiratorias, renales y endocrino-metabólicas; sumándole a esto, en las poblaciones más vulnerables como son de adultos maduros (40 – 64 años de edad); de adultos mayores (> de 65 años); explicarían la tasa elevada de mortalidad y las implicaciones de la aparición de casos críticos, debido a la gravedad de las complicaciones evolutivas conduciendo a la vida humana a un desenlace fatal.
Efectos de la pandemia por COVID-19 en la salud mental de adolescentes
Authors: López-Medina Lizbeth Ivonne , Monar-González José Ignacio , Andrade-Cáceres Andrés Rodrigo , Alfonso-González Iruma 
Published: May 2022

Objetivo: Analizar los efectos de la pandemia por COVID-19 en la salud mental de adolescentes. Método: Descriptiva documental. Resultados: 15 articulos relacionados al tema de investigación. Conclusión: Mediante el profundo análisis realizado, se puede concluir que, todas las personas se han visto afectadas por la pandemia , sin embargo la población que más sufrió han sido los adolescentes, debido a que han tenido que adaptarse a mecanismo establecidos para frenar el contagio del COVID-19, dejando así a un lado las actividades cotidianas que antes realizaban cómo asistir a clases presencialmente, interactuar con otras personas y concurrir a espacios o eventos públicos ,como consecuencia en el futuro de estos jóvenes se puede generar una serie de trastornos emocionales , puesto que la adolescencia es una etapa fundamental y crucial para el desarrollo de hábitos sociales.
SUCCESSFUL AGING: THE CONTRIBUTION OF PERSONALITY VARIABLES
Authors: Van Dendaele Elina , Pothier Kristell , Bailly Nathalie 
Published: May 2022

Understanding social, economic, and psychological factors are important for promoting elderly health. Rowe and Kahn (1997) described three main components for "successful aging" (SA): avoiding disability and disease, high cognitive and physical capacities, and active engagement in one's life. Psychological dimensions (i.e., personality) have not been sufficiently studied yet. However, they could be considered to define SA. This study aimed to determine whether physical, cognitive, social, and personality factors were associated with SA. A total of 2109 participants living at home (53.39% men; mage =75,38±8.11) – from the Survey of Health, Aging, and Retirement in Europe (SHARE dataset release 7.0.0 of 2017) – completed questionnaires measuring physical (mobility, number of diseases, IADL, BMI) and cognitive (memory, executive function) health, social engagement, and personality (Big Five Inventory). These variables were gathered into three distinct blocks: sociodemographic characteristics (age, sex), model’s Rowe and Kahn variables (physical, cognitive, social engagement), and personality. SA was assessed by the Euro depression scale. A correlation matrix was computed to examine the interrelationships between all variables. We then performed linear regression analysis when it was appropriate. A higher level of motor and cognitive abilities correlated with a lower level of depressive symptoms (r=0.34; p<.001; r=-.20; p<.001; r=-.17; p<.001). The number of diseases was positively correlated with depressive symptoms (r=0.26; p<.001). The more engaged people were, the fewer depressive symptoms they had (r=0.09; p=.019). An effect of the level of education on depressive symptoms (F(5,847)= 7.06; p<.001) was found: people with a higher educational level had a lower depression score than those with a lower educational level. A lower level of neuroticism, higher level of agreeableness, and conscientiousness were significantly correlated with a lower level of depressive symptoms (r=0.41; p<.001; r=-.09; p<.028; r=-.08; p=.028). Linear regression analyses showed that personality variables explained 11% of the variance of depression scores, beyond sociodemographic characteristics (age, sex) (9%) and variables in the Rowe and Kahn model (10%). The three blocks, all together, explained 29% of the variance of the depression scores. In line with Rowe and Kahn’s model (1997), results showed that physical, cognitive, and social factors from the SHARE study partially explained SA (i.e., absence of depressive symptoms here). Interestingly, personality variables also explained a significant proportion of depressive symptoms. Personality may have an important role in addressing SA: adapting the care as well as the prevention to encourage the elderly to engage in physical, social, or cognitive activities.
ACCULTURATION, PARENTING PRACTICES AND THE TRANSMISSION OF CULTURAL AND RELIGIOUS VALUES IN MUSLIM IMMIGRANT FAMILIES
Authors: El Brashy Dalia , Miglietta Anna 
Published: May 2022

Acculturation is a complex and dynamic process associated with various difficulties and challenges that play a major role in raising children. This is especially true for Muslim immigrant families where instilling traditional values and a strong sense of ethnic and religious identity is a primary aspect of the parenting process. This study addresses the process of cultural negotiation undertaken by immigrant Muslim parents and analyses how it affects their children's education and parenting practices. Eleven Muslim immigrant adults with children, settled in Italy from an average of 25 years (F= 9; mean age= 48) participated to a semi-structured interview about their experiences of raising their children in relation to their origins and Italian culture. Atlas-ti was used for thematic analysis. The results showed that the educational role of parents in these families is challenged by the difficulty of finding a match between the traditional model of education and the mainstream model. This difficulty intertwines with the one related to the need to reconcile different needs, namely, the need to preserve and transmit religious and cultural values, and the need to adapt to the values that they and their children learn through interaction with the plural society. In response to this challenge, parents seem to prefer separation as an acculturation strategy, in terms of the content of traditional and religious values, while maintaining a negotiating space for these values. Instead, in teaching these values, they have moved increasingly closer to the Italian model of parenting, which is based on flexibility and dialogue, thus adopting integration in the field of parenting strategies. This research was the preliminary phase of an intervention project aimed at empowering the Islamic community of Turin, Italy, to support families in practicing intentional parenting in order to address the challenges related to the migratory context. In other words, to promote the acquisition of parenting skills that can meet both children's identity needs and parents' needs for appreciation and cultural transmission, and also prevent problems and psychological distress caused by cultural conflicts. It emerged from both the research and the intervention project that the need to develop a model of "parenting in migration" is shared by the entire Muslim community and requires a collective and collaborative effort to promote this process by creating spaces for discussion and by activating the resources available in the community that can guide and accompany parents in difficulty in their educational role, creating synergies with the services offered by the territory.
Weakly Linked Embeddings of Pairs of Complete Graphs in $\mathbb{R}^3$
Authors: Di James , Flapan Erica , Johnson Spencer , Thompson Daniel , Tuffley Christopher 
Published: May 2022

Let $G$ and $H$ be disjoint embeddings of complete graphs $K_m$ and $K_n$ in $\mathbb{R}^3$ such that some cycle in $G$ links a cycle in $H$ with non-zero linking number. We say that $G$ and $H$ are weakly linked if the absolute value of the linking number of any cycle in $G$ with a cycle in $H$ is $0$ or $1$. Our main result is an algebraic characterisation of when a pair of disjointly embedded complete graphs is weakly linked.
As a step towards this result, we show that if $G$ and $H$ are weakly linked, then each contains either a vertex common to all triangles linking the other or a triangle which shares an edge with all triangles linking the other. All families of weakly linked pairs of embedded complete graphs are then characterised by which of these two cases holds in each complete graph.