bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PERSISTÊNCIA DE NOVOS CASOS DE HANSENÍASE DE 2012 A 2021 NO TERRITÓRIO DA REDE REGIONAL DE ATENÇÃO À SAÚDE DE MARÍLIA-SP E SUA RELAÇÃO SOCIOECONÔMICA: UM ESTUDO ECOLÓGICO
Authors: Carneiro de Camargo Ana Letícia , Chabrour Chehadi Amanda , Leoneide Servano e Dias Nicolau Gelmária , Eugênio Gil Guilherme , De Almeida Martins Matheus , Helou Doca Heloisa 
Published: September 2022

Introdução: O Brasil é a segunda nação com mais novos casos de Hanseníase no mundo. Em comparação ao restante do país, a região Sudeste é referência na prevenção e tratamento da doença. O presente estudo tem o objetivo de interseccionar as informações de saúde sobre Hanseníase quanto ao modo de entrada no sistema de saúde dos casos diagnósticos por ano, escolaridade e quantidade de lesões cutâneas dos pacientes a fim de verificar as relações do contexto socioeconômico na persistência da doença na macrorregião do Centro-Oeste do estado de São Paulo. Métodos: Estudo epidemiológico ecológico descritivo, retrospectivo, com dados secundários sobre os casos da Hanseníase por ano diagnóstico no período de 2012 a 2021 no território da Rede Regional de Atenção à Saúde (RRAS) 10, do Departamento Regional de Saúde de Marília-SP (DRS IX), a qual engloba 62 municípios da macrorregião do Centro-Oeste paulista. Resultados: Quanto ao modo de entrada dos casos ao sistema de saúde, há predomínio de novos casos. A maior parte são de indivíduos com 4ª série do EF incompleta ou completa, enquanto a menor parcela dessa população possui Educação Superior incompleta ou completa. Há predomínio de condições mais graves com mais de cinco lesões cutâneas. Discussão: Sob análise da variável escolaridade como representante da condição socioeconômica, embora a Hanseníase possa atingir qualquer indivíduo, verifica-se maior prevalência em grupos carentes socioeconomicamente. O predomínio de pacientes multibacilares pode estar relacionado também à escolaridade, uma vez que a baixa compreensão da população sobre a Hanseníase faz com que a busca por atendimento médico aconteça somente quando a doença já está em estágios mais avançados. Conclusão: Há coexistência entre circunstâncias sociais, inferidas pela escolaridade, e prevalência dos casos de Hanseníase no território e período estudados. Reforça-se a necessidade de ações educativas contínuas sobre a doença à população.
Analisis Pembelajaran Praktika Laboratorium Metode Daring terhadap Pencapaian Ketrampilan Mahasiswa Pendidikan Vokasi Keperawatan Poltekkes Kemenkes Yogyakarta
Authors: Lestari Tami Eka , Laasara Nurun 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui ketercapaian ketrampilan mahasiswa dengan pmbelajaran praktika metode daring serta menganalisis kendala kendala yang didapat selama pembelajaran praktika metode daring. Penelitian ini menggunakan penelitian kuantitatif. Penelitian ini dilaksanakan di Laboratorium Poltekkes Kemenkes Yogyakarta. Pengambilan data penelitian dilaksanakan pada bulan September-November 2021 dengan cara memberikan kuesioner kepada 187 mahasiswa Prodi DIII keperawatan dan Sarjana Terapan keperawatan yang telah melakasanakan Praktika di Laboratorium selama Masa pandemi. Hasil dari penelitian ini menunjukan bahwa lebih dari 50 % responden tidak setuju bahwa metode pembelajaran praktika secara daring lebih efektif, mudah dipelajarai dan melatih belajar mandiri. Mahasiswa lebih setuju dengan metode pembelajaran secara tatap muka langsung. Sebagian besar responden (65%) menyatakan bahwa pembelajaran secara daring dapat membantu mempelajari 50 % dari pencapaian ketrampilan yang ada di RPS yang bisa dilakukan secara Secara mandiri. Namun demikian sebagian responden hanya bisa mempelajarai 25 % dari materi yang diberikan. Secara umum dari pertanyaan yang diberikan, responden rata rata menjawab setuju bahwa metode pembelajaran daring dapat membantu tercapainya kompetensi praktik meskipun tidak sampai 100 % rata rata hanya 25 %. Sebagian besar responden (55%) menyatakan merasa jenuh merasa jenuh belajar praktik metode daring. Responden sebagian besar (63%) menyatakan kurang senang dengan belajar praktik metode daring. Responden (58%) menyatakan lebih termotivasi untuk belajar praktik dengan bimbingan langsung dari dosen/instruktur. Secara umum dari pertanyaan yang diberikan, rata-rata menjawab setuju bahwa kurang senang dan tidak termotivasi dalam pembelajaran praktik laboratorium secara daring. Kendala yang dihadapi sebagian besar mahasiswa adalah sinyal yang kurang bagus dan alat/instrumen praktika yang kurang sesuai.
Application of Government Regulations in the Implementation of Face-to-face Learning at SMA Negeri 1 Nita in the New Normal Period
Authors: Bela Elisabeth 
Published: September 2022

This study aims to find out 1) Application of government rules in the implementation of face to face learning, 2) Constrainst faced by schools in the application of government rules for implementing face to face learning, 3) Solutions in overcoming obstacles faced in SMA Negeri I Nita new normal period. This research was conducted at SMA Negeri 1 Nita. This study uses qualitative research methods with data collection techniques used, namely, interview techniques, observations and documentation. Based on the results of interviews with school principals, teachers, students, staffing staff, security quards, and parents in the application of health protocol. 1) The application of health protocol rules is still not implemented properly in accordance with the rules issued by the government, 2) Constraints of students are less obedient during running health protocols such as using masks, maintaining limited learning and learning time, 3) Sulitions ladies and gentlemen, teachers must remid all svhool members to continue to apkly health protocols during face to face learning in the new normal period
characterization of physico-chemical properties and heavy metal concentrations of surface water receiving effluent from champion breweries plc in uyo, akwa ibom state, nigeria
Authors: Akpan, S. Udeme  , Umana Umana 
Published: September 2022

Physico-chemical properties and heavy metal concentrations of surface water receiving effluent from Champion Breweries Plc, Uyo, Akwa Ibom State were analysed to evaluate the effect of the effluent on the physico-chemical properties and heavy metal concentrations of the surface water. The water samples were collected using polyethylene bottles that were initially rinsed with 10% hydrochloric acid (HCl) then with the sample water. Two samples were collected at each sampling point. One was for physicochemical properties determinations while the other sample was for heavy metal analysis. HNO3 was added in the samples for heavy metal analysis for preservation of the metals. The collected samples were stored in an ice-packed cooler kit and taken to the laboratory for analysis. The results showed that the temperature of the water was within the permissible limit. Mean pH was lower than the permissible range for drinking water especially during the dry season. Turbidity was above the permissible limit in both dry/wet seasons. Dissolved oxygen was below the permissible limit. Mean biochemical oxygen demand was above the permissible limit. The result of the ratio of chemical oxygen demand to biochemical oxygen demand showed that the compounds in the water were relatively biodegradable. Total suspended solid was above the permissible limit. Mean total dissolved solid was below the permissible limit. Mean electrical conductivity was also below the permissible limit. The concentration of NH4 was at toxic level. The concentrations of nitrate, nitrite, phosphate and sulphate were below the permissible limits indicating non-toxicity and lack of these nutrient elements in the water. The contents of Fe, Pb, Zn, Cd, Cr, Co and Mn were above permissible levels. The effluent from Champion breweries is considered to be one of the major sources of pollutants of surface water in this area, which efficient treatment of effluent before disposal is recommended.
Stars in Your Hand
Authors: Arcand Kimberly , Watzke Megan 
Published: September 2022

An illustrated guide to exploring the Universe in three dimensions.
Astronomers have made remarkable discoveries about our Universe, despite their reliance on the flat projection, or 2D view, the sky has offered them. But now, drawing on the vast stores of data available from telescopes and observatories on the ground and in space, astronomers can now use visualization tools to explore the cosmos in 3D. In Stars in Your Hand, Kimberly Arcand and Megan Watzke offer an illustrated guide to exploring the Universe in three dimensions, with easy-to-follow instructions for creating models of stars and constellations using a 3D printer and 3D computer imaging.
Stars in Your Hand and 3D technology make learning about space an adventure. Intrigued by the stunning images from high-powered telescopes? Using this book, you can fly virtually through a 3D spacescape and hold models of cosmic objects in your hand. Arcand and Watzke outline advances in 3D technology, describe some amazing recent discoveries in astronomy, reacquaint us with the night sky, and provide brief biographies of the telescopes, probes, and rovers that are bringing us so much data. They then offer images and instructions for printing and visualizing stars, nebulae, supernovae, galaxies, and even black holes in 3D. The 3D Universe is a marvel, and Stars in Your Hand serves as a unique and thrilling portal to discovery.
Neurologic Complications of Smallpox and Monkeypox
Authors: Billioux B. Jeanne , Mbaya Oliver Tshiani , Sejvar James , Nath Avindra 
Published: September 2022

ImportanceOrthopox viruses include smallpox virus, a once feared but now eradicated virus, as well as monkeypox virus. Monkeypox is an emerging virus initially isolated in 1958, previously unrecognized outside sub-Saharan Africa until a worldwide outbreak in May 2022. It is important to review known neurologic consequences of both these viruses, as complications of smallpox may be relevant to monkeypox, though complications of monkeypox may be rarer and perhaps less severe.ObservationsThis was a literature review of the known neurologic complications of smallpox, which include encephalitis, transverse myelitis, and acute disseminated encephalomyelitis among others; historical complications of smallpox vaccination, including postvaccinal encephalomyelitis; and the known neurologic complications of monkeypox, which include headaches and mood disturbances, as well as rare presentations of encephalitis, transverse myelitis, and seizures. Of concern is the possibility of viral persistence and systemic complications in immunocompromised individuals. Also provided were considerations for diagnosis, current treatment, and prevention of monkeypox.Conclusions and RelevanceMonkeypox should be considered in high-risk populations who present with neurologic syndromes. Diagnosis may require serology and polymerase chain reaction testing of blood and spinal fluid. Antiviral therapy should be initiated early in the course of the illness.
Impact of Planar and Vertical Organic Field‐Effect Transistors on Flexible Electronics
Authors: Nawaz Ali , Merces Leandro , Ferro Letícia M. M. , Sonar Prashant , Bufon Carlos C. B. 
Published: September 2022

AbstractThe development of flexible and conformable devices, whose performance can be maintained while being continuously deformed, provides a significant step toward the realization of next‐generation wearable and e‐textile applications. Organic field‐effect transistors (OFETs) are particularly interesting for flexible and lightweight products, because of their low‐temperature solution processability, and the mechanical flexibility of organic materials that endows OFETs the natural compatibility with plastic and biodegradable substrates. Here, an in‐depth review of two competing flexible OFET technologies, planar and vertical OFETs (POFETs and VOFETs, respectively) is provided. The electrical, mechanical, and physical properties of POFETs and VOFETs are critically discussed, with a focus on four pivotal applications (integrated logic circuits, light‐emitting devices, memories, and sensors). It is pointed out that the flexible function of the relatively newer VOFET technology, along with its perspective on advancing the applicability of flexible POFETs, has not been reviewed so far, and the direct comparison regarding the performance of POFET‐ and VOFET‐based flexible applications is most likely absent. With discussions spanning printed and wearable electronics, materials science, biotechnology, and environmental monitoring, this contribution is a clear stimulus to researchers working in these fields to engage toward the plentiful possibilities that POFETs and VOFETs offer to flexible electronics.
Boosting the Stability of Oxygen Vacancies in α‐Co(OH)2 Nanosheets with Coordination Polyhedrons as Rivets for High‐Performance Alkaline Hydrogen Evolution Electrocatalyst
Authors: Jiang Li‐Wen , Huang Yuan , Zou Yang , Meng Chao , Xiao Yi , Liu Hong , Wang Jian‐Jun 
Published: September 2022

AbstractThe strong alkaline electrolytes are utilized in various key electrochemical applications and the severe corrosion by hydroxyl ions endows the development of high‐performance electrode materials with a great challenge. Here, an effective strategy is demonstrated to stabilize α‐Co(OH)2 under harsh alkaline electrochemical condition by coordination polyhedron pinning (MoO42−, WO42−) on the surface for hydrogen evolution reaction (HER). The addition of MoO42− in 1 m KOH can inhibit the attack of hydroxyl ions on oxygen vacancies in α‐Co(OH)2, and simultaneously modulate the electronic structure of active sites for HER. The theoretical calculations and experimental results reveal that MoO42− can be riveted on the surface of α‐Co(OH)2 to greatly stabilize oxygen vacancies and inhibit the formation of soluble ions of Co(OH)3−. The resultant active sites exhibit reduced maximum energy barriers for the optimized alkaline HER. Additionally, MoO42− near the interface between α‐Co(OH)2 and electrolyte can alleviate the accumulation of hydroxyl ions on α‐Co(OH)2 due to the electrostatic repulsion, improving the stability toward HER. This work offers insight into the role of coordination polyhedron ions in regulating and enhancing the stability of α‐Co(OH)2 for various potential electrochemical applications in alkaline electrolyte.
Synthesis of hierarchical ZSM‐5 microspheres with superior performance for catalytic methanol‐to‐olefin conversion
Authors: Zhang Yali , Zhang Kai , Shang Chao , Wang Xiaoning , Wu Lei , Huang Guoqing , Wang Hao , Sun Qiming , Chen Xiao Dong , Wu Zhangxiong 
Published: September 2022

AbstractMethanol‐to‐olefin (MTO) conversion on zeolites has encountered severe coke deposition and rapid deactivation. Creating different levels of porosity is essential to mitigate such issues. Herein, we demonstrate a facile and green strategy to synthesize uniform and hierarchically macro/mesoporous ZSM‐5 microspheres by combining spray‐freeze drying and steaming‐assisted crystallization (SAC). The structure, crystallinity, and porosity of the zeolite microspheres are controlled by adjusting the water/gel mass ratio and time in the SAC process. The structure evolution during the SAC process is revealed. In the catalytic MTO reaction, the representative hierarchically porous ZSM‐5 catalyst exhibits superior catalytic performance. At a very high weight hourly space velocity of 18 h−1, it shows a dramatically prolonged lifetime (47 h at >99% conversion) and much‐improved selectivity to ethylene and propylene compared with the conventional microporous ZSM‐5 and nano‐sized ZSM‐5. The enhanced performance is originated from the hierarchical structure and suitable acidity of the ZSM‐5 microspheres.
Approach to a patient with “double refractory” chronic lymphocytic leukemia: “Double, double toil and trouble” (Shakespeare)
Authors: Aronson Julia H. , Skånland Sigrid S. , Roeker Lindsey E. , Thompson Meghan C. , Mato Anthony R. 
Published: September 2022

AbstractAs patients continue to live longer with chronic lymphocytic leukemia, it has become evident that there is an unmet treatment need for patients who have progressed on multiple lines of therapy. In this article, we attempt to define the “double refractory” patient as resistant to both Bruton's tyrosine kinase inhibitors (BTKi) and venetoclax for which prognosis is poor and there remains no standard of care. We further examine the mechanism of resistance to these targeted agents and discuss the current landscape for managing this patient population. Finally, we explore data supporting promising new agents, including non‐covalent BTKi, chimeric antigen receptor T cells, and additional classes of agents currently in development.
Metal‐Free Aminomethylation of Pyrazolones: Direct Access to 4‐Aminomethylated Pyrazolones
Authors: Phakdeeyothin Kunita , Viriyanukul Tarm , Udomsasporn Kwanchanok , Phomphrai Khamphee , Yotphan Sirilata 
Published: September 2022

AbstractA metal‐free aminomethylation of pyrazolones is accomplished with cyclic amines such as morpholine and piperazine analogues in the presence of (diacetoxyiodo)benzene at ambient temperature. Various sensitive functional groups can be compatible under the reaction conditions. Preliminary mechanistic investigation reveals that morpholine or piperazine analogues are likely to be the source of methylene group. This method provides a straightforward route for the preparation of 4‐aminomethylated pyrazolone derivatives under mild conditions.
Palladium‐Catalyzed Dehydrogenative Synthesis of Imidazoquinolines in Water
Authors: Nakayama Taku , Harada Shogo , Kikkawa Shoko , Hikawa Hidemasa , Azumaya Isao 
Published: September 2022

AbstractWe report a synthesis of imidazoquinolines via dehydrogenative coupling of 3,4‐diaminoquinolines with benzylic alcohols utilizing our π‐benzylpalladium(II) system in water. Readily available benzylic alcohols initially undergo catalytic dehydrogenation to form benzaldehydes, which are then reacted with 3,4‐diaminoquinolines via sequential cyclocondensation/aromatization, leading to the formation of imidazoquinolines. This experimentally simple and practical one‐pot procedure provides direct access to the desired products without adding strong bases, toxic oxidants or other additives. Several experiments were carried out toward an understanding of the reaction mechanism to propose plausible catalytic cycles.	The dehydrogenative coupling was found to be first order with respect to the benzyl alcohol and Pd catalyst, and zero order with respect to the 3,4‐diaminoquinoline substrate. A kinetic isotope effect of 3.1 was observed by separately determining the reaction rates of benzyl alcohol and benzyl‐α,α‐d2 alcohol. Water molecules accelerate the catalytic dehydrogenative coupling, suggesting that they act as a proton donor to activate the benzylic alcohols by a hydrogen‐bonding network.
Exploring in vitro effect of silver nanoparticles and Holothuria parva extracts on kinetics and stability of α‐amylase
Authors: Edrispour Zeynab , Homaei Ahmad 
Published: September 2022

AbstractDiabetes is a chronic metabolic disorder characterized by elevated blood glucose levels. Major limitations of synthetic drugs, including high cost, efficacy, and adverse side effects, have prompted researchers to seek more effective and low‐cost alternative therapies with fewer adverse effects. Marine life forms are considered the most important sources of biologically active natural products due to their secondary metabolites. In this research, sea cucumber Holothuria parva was collected from coastal areas of Bandar Lengeh, Hormozgan, Iran, and was then subjected to extraction. The results showed that compounds extracted from Holothuria parva had a stimulatory effect on enzyme activity, and in the presence of these compounds, the Vmax value of the enzyme was increased about two times, while the Km value was reduced. The phosphate buffer form of extracts had the greatest impact on enzyme activity. Upon an increase in the concentration of silver nanoparticles (AgNPs), the α‐amylase activity was inhibited in parallel. Silver nanoparticles exhibited the highest enzyme inhibition with an IC50 of 0.86 mg/ml. Silver nanoparticles showed anti‐α‐amylase activity and had the ability to decrease intestinal glucose uptake in diabetic individuals when prescribed as a novel supplementary medicine.
Cultural capital, curriculum policy and teaching Latin
Authors: Gatley Jane 
Published: September 2022

AbstractLatin is currently being trialled as a subject in 40 state secondary schools in England. This paper focuses on one of the justifications of this trial: that teaching Latin in state secondary schools provides students with cultural capital which in turn counters social injustice. By taking the example of Latin as a starting point, I reach two conclusions about cultural capital. The first is that providing students with cultural capital can be good for some individuals, and so justified on a case‐by‐case basis depending on context. However, this justification does not hold for curriculum policy making. My second conclusion is that in the long term, pursuing cultural capital as part of curriculum policy exacerbates the social injustices it purports to address. Wherever an activity is introduced for the sake of cultural capital rather than its educational value, educationally valuable activities risk being pushed off the curriculum, potentially degrading the educational value of the curriculum. In the case of teaching Latin, it may provide benefits to particular students, but as part of curriculum policy it risks exacerbating social injustices and undermining the educational value of school curricula. Going beyond the place of Latin on the curriculum, I argue that all appeals to cultural capital provide a poor basis for curriculum policy making.
“Decoding MH”—A de‐stigmatization campaign in the Hong Kong Police Force
Authors: Chan Elaine Yin Ling , Lui Jasmine Tsz Ting , Mak Alison Lai Ping , Lau Edmond Kam Lun 
Published: September 2022

AbstractPolice officers are under high level of stress given the intense and emergent work nature. If left untreated, their mental wellbeing would be at risk and work performance compromised. However, mental health stigma is common among police officers and is perpetuated by factors like police cultures emphasizing toughness and self‐reliance. In view of this, since 2016, the Hong Kong Police Force had launched a holistic campaign for Force members which was the first among law enforcement organizations in Hong Kong, aiming to reduce stigma, by enhancing mental health knowledge and decreasing negative attitudes and behaviors towards mental health issues. The programme incorporated standardised trainings of the Mental Health First Aid course with examples modified to the local police context, and psychoeducation via the use of digital medium and sharing by public figures. Positive feedback was received. It was foreseen that the campaign effects would increase Force members' awareness of their mental health, encourage help‐seeking and facilitate officers' decision making when encountering crises in the community.
Design of N‐Doped Carbon Materials Assisted Co−CoOx Anchoring on Mesoporous Silica Spheres Catalyst for Levulinic Acid Valorization
Authors: Zhang Guanyi , Zhao Kai , Zhu Qingqing , Kong Xiangjin 
Published: September 2022

AbstractThe design of robust catalyst was of great significance for the valorization of biomass platforms. Herein, an efficient Co@mSiO2−CN catalyst was constructed via a simple impregnation‐mixing‐pyrolysis strategy, which could give 100 % yield of γ‐valerolactone from levulinic acid for no less than five cycles under a relatively mild reaction conditions (160 °C, 1.5 MPa H2,3 h).The results of catalyst characterizations and comparative experiments showed that the introduction of nitrogen‐doped carbon materials promoted the dispersion of Co and enhanced the Lewis acidity of the catalyst, thereby promoting the dissociation of H2 and the activation of C−O, respectively. The synergistic effect between the hydrogenation metal sites and the Lewis acidic site ensures excellent activity of the catalyst.