bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose-Derived Stem Cells (ADSCs): a review article
Authors: Pramana Ida Bagus Putra , Oka Anak Agung Gde , Astawa I Nyoman Mantik , Mahadewa Tjokorda Gde Bagus 
Published: February 2022

Introduction: Stem Cells (SC) are cells having characteristic features of self-renewal and plasticity that can differentiate and proliferate into many types of cells to form an individual. This literature study aims to evaluate the Adipose-Derived Stem Cells (ADSCs) comprehensively.Methods: A comprehensive literature search was conducted by the author to obtain relevant studies from PubMed, MEDLINE, Embase, PreMEDLINE, Embase, PsycINFO, Scopus, and Cochrane for the last fifteen years. The author sought articles with the following keywords: Adipose-Derived Stem Cells, AND Fibrosis, OR Wound Healing, OR Growth Factor, hypoxic culture OR, Normoxic Culture, OR cytokine.Results: ADSCs become one of the strong potential stem cell-based therapies, for instance, preventing fibrosis tissue formation in the wound healing process. The source is mainly on the body’s surface, and harvesting using a minimally invasive procedure made ADSCs superior to the other stem cell sources. Using a better precondition technique, such as the hypoxia precondition technique, can increase the proliferation of stem cells and the viability of stem cells.Conclusion: ADSCs are a source of visible cell-based therapy to be currently used. ADSCs can counteract fibrosis by the anti-inflammatory and anti fibrosis effects.
The effect of knowledge on attitude of pregnant women in prevention of worm infections
Authors: Sulastri Sulastri , Triana Diah Ayu Agus 
Published: February 2022

Introduction: Helminthiasis is an endemic and chronic disease caused by parasitic worms with a high prevalence rate and is non-fatal, but it affects the health of the human body by reducing the absorption of nutrients and proteins in infected individuals and reducing blood levels in the human body so that if it occurs in pregnant women, it can affect pregnancy and childbirth. This study aimed to examine the influence of findings on attitudes of pregnant women towards the prevention of helminthiasis in the work area of the Gatak Health Center, Sukoharjo. Methods: This study used a descriptive observational research method with a cross-sectional approach with 144 samples taken with an all-sampling technique. Results: Statistical test shows that the value of p 0.000 is less than alpha 0.05, which means there is a relationship between the knowledge the Pregnant women and the attitude of pregnant women insist the mother in preventing the occurrence of worms. Conclusion: The pregnant woman's posture is classified as functional because it influences the mother in the prevention and treatment of helminthiasis and affects her state of health.
Analysis of the quality of life of college students and students in Indonesia who were undergoing large-scale social restriction (LSSR) during the COVID-19 pandemic
Authors: Hadning Ingenida , Salsabila Anis Khoirul 
Published: February 2022

Introduction: The Indonesian government's efforts to deal with the COVID-19 pandemic are implementing a Large-Scale Social Restriction (LSSR) policy. This LSSR policy becomes a problem for the quality of life of the people who carry out the policy, including college students and students. This research aims to determine the quality of life of college students and students in Indonesia who undergo LSSR during the COVID-19 pandemic.Methods: This research is a descriptive study with a cross-sectional approach. This research used accidental sampling methods by 30 days of distributing e-questionnaires. The samples used in this study were college students and students who were undergoing the LSSR in Indonesia. The instrument used for this research was WHOQOL-BREF. The quality of life was analyzed descriptively by calculating each domain's average transformed score.Results: Through this research, obtained 280 respondents consisting of 67 men and 213 women. Respondents aged 12-17 years were nine respondents, and 18-25 years were 271 respondents. The majority of respondents underwent LSSR for 9-12 weeks. Analysis of quality of life showed that the physical health domain had an average of 62.65 ± 0.87; psychological health of 62.58 ± 1.04; social relations of 53.76 ± 1.16; and the environment 61.53 ± 0.98.Conclusion: The conclusion in this study is that college students and students who undergo PSBB have good physical health, good psychological health, moderate social relationship quality, and good environmental quality.
A case of total atrioventricular (AV) block with acute coronary syndrome at a Negara tertiary care hospital: a diagnostic and therapeutic challenge in a resource-limited setting
Authors: Chandra I Made Anggita , Wirawan Narakusuma 
Published: February 2022

Background: Total atrioventricular (AV) block describes a conduction disturbance from the atria to the ventricles via conduction through the atrioventricular node (AV node), acute coronary syndromes of mechanism, and being to cause mortality.Case Illustration: A 57-year-old man came with complaints of weakness two months ago, worsening for the last one week accompanied by left side chest pain. The patient is an active smoker without a history of chronic disease. ECG shows a total AV block with a junctional escape rhythm. Patients were treated with 1x75mg clopidogrel therapy, 1 x 80 mg aspirin, 3 x 5 mg ISDN, 5 mg / kg BW / minute, dopamine drip and 1 x 25 mg spironolactone. After being treated for three days with an increase in the maximum dopamine dose, the patient still felt weakness and chest pain on the left side, so the patient was referred to a tertiary hospital for echocardiography and percutaneous coronary intervention (PCI). Conclusion: a total atrioventricular (AV) block after an acute MI is a rare case. Clinical suspicion and proper evaluation of patients is essential for an early diagnosis, referral, and timely definitive treatment, to decrease the morbidity and mortality associated with this disease. Successful reperfusion at AV node is beneficial to the conduction system.
A discrepancy of blood group A with missing antigen in anorectal malformation patient at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia
Authors: Atmanto Yohanes Kusumo Adi Arji , Samad Raehana , Muhiddin Rachmawati , Arif Mansyur 
Published: February 2022

Background: Blood group discrepancy is a discrepancy in the results of the cell grouping with serum grouping examination. The source of discrepancy is from technical errors or a patient's medical status such as age, disease, history of blood transfusion and medication, pregnancy. This case study aims to evaluate a discrepancy of blood group A with missing antigen in anorectal malformation patient at Dr. Wahidin Sudirohusodo Hospital, Makassar, IndonesiaCase Presentation: A male baby, 6 months 19 days old, was unable to defecate since birth post-colostomy. Physical examination reveals anemia. A routine blood test showed a hemoglobin level of 8.8 g/dL. The diagnosis was high position anorectal malformation post colostomy suspect Hirschsprung Disease, with 110 cc Packed Red Cell (PRC) transfusion plan. A routine pre-transfusion procedure was performed. It was found a discrepancy of blood group A with missing antigen. Crossmatching with blood groups O and A both gave compatible results. Examination of peripheral blood smear after PRC blood group A transfusion found no signs of hemolytic.Conclusion: Blood group discrepancy, in this case, was due to missing antigen, which was caused by the possibility of gastrointestinal bacterial infection.
Obesitas sebagai faktor risiko terjadinya peningkatan kadar trigliserida dalam darah: tinjauan pustaka
Authors: Salim Baiq Rissa Khaerawati , Wihandani Desak Made , Dewi Ni Nyoman Ayu 
Published: February 2022

Obesity is considered a major factor in the emergence of various diseases such as coronary heart disease, stroke ischemia, and type 2 diabetes mellitus in developed and developing countries. Obesity is defined as an increase in body weight above 20% of normal limits and is associated with abnormal serum lipoprotein levels. Obese people are more at risk for diseases such as Diabetes Mellitus type 2, stroke and other diseases. Excessive fat accumulation in obese people results in increased amounts of free fatty acids hydrolyzed by endothelial lipoprotein lipases. This increase triggers the production of oxidants that have a negative effect on the endoplasmic reticulum and mitochondria. The free fatty acids released due to excessive fat accumulation also inhibit lipogenesis, resulting in an increase in triglyceride levels in the blood. This literature study aims to determine whether obesity is a risk factor for increased blood triglyceride levels based on the relevant literature. Obesitas dianggap sebagai faktor utama munculnya berbagai macam penyakit seperti penyakit jantung koroner, stroke iskemik, dan diabetes mellitus tipe 2 yang terjadi di negara maju maupun negara berkembang. Obesitas diartikan sebagai peningkatan berat badan di atas 20% dari batas normal dan berhubungan dengan kadar lipoprotein serum tidak normal. Orang obesitas lebih berisiko untuk mengalami penyakit seperti Diabetes Mellitus tipe 2, stroke dan penyakit lainnya. Penumpukan lemak yang berlebihan yang terjadi pada orang obesitas mengakibatkan meningkatnya jumlah asam lemak bebas yang dihidrolisis oleh lipoprotein lipase endotel. Peningkatan ini memicu produksi oksidan yang berefek negatif terhadap retikulum endoplasma dan mitokondria. Asam lemak bebas yang dilepaskan karena adanya penimbunan lemak yang berlebihan juga menghambat terjadinya lipogenesis sehingga mengakibatkan peningkatan kadar trigliserida dalam darah. Tinjauan pustaka ini bertujuan untuk mengetahui apakah obesitas sebagai faktor risiko peningkatan kadar trigliserida dalam darah berdasarkan pada studi literatur yang relevan.
Kesesuaian pewarnaan gram dengan kultur darah sebagai prediktor nilai kritis kasus bakteremia di Rumah Sakit Umum Pusat Sanglah, Denpasar
Authors: Harindana Putu Yoska Arya , Iswari Ida Sri , Setyojatmiko Indramawan , Fatmawati Ni Nengah Dwi 
Published: February 2022

Background: One of the considerations for giving empiric antibiotics in bacteremia cases is gram staining (GS) results. Accurate and fast results are required in distinguishing infection-caused bacteria. However, the data on how much the corresponding gram stain results with bacterial growth in blood cultures are still insufficient.Aim: The study aims to compare Gram stain results with bacterial growth in positive blood cultures.Methods: A cross-sectional analytic study obtained data from the VITEK® 2 Compact (bioMérieux) results for six months (January - June 2020). Data involved all blood cultures examined as many as 509.Results: Of the 509 blood samples, 46 were reported as critical values for bacteremia. Gram-negative bacillus bacteria were identified in 39.13% of the gram staining (GS) and 45.65% of the blood culture (BC) samples. Gram-positive bacteria appeared in 56.52% of GS and 52.17% of BC. MBRO (multidrug-resistant organisms) bacteria were identified in the proportion of 11%, then 13% from ESBL (extended-spectrum beta-lactamase) bacteria, and they remain as 4% MRSA (methicillin-resistant Staphylococcus aureus) bacteria. The higher result, 76% of the data was confirmed from the non-ICU patients.Conclusion: GS can be used as a reference for empiric antibiotic therapy due to its effectiveness, and it has a high degree of similarity with positive blood culture results. Latar belakang: Salah satu pertimbangan pemberian antibiotika empiris pada kasus bakteremia adalah berdasarkan hasil pewarnaan gram. Dibutuhkan hasil yang akurat dan cepat dalam membedakan bakteri penyebab infeksi. Namun sedikit data tentang berapa besar kesesuaian hasil pewarnaan gram dengan pertumbuhan bakteri pada kultur darah. Untuk membandingkan hasil pewarnaan gram dengan pertumbuhan bakteri pada kultur darah yang positif.Metode: Penelitian ini merupakan penelitian analitik cross-sectional. Data diperoleh dari hasil VITEK® 2 Compact (bioMérieux) selama enam bulan (Januari – Juni 2020). Sampel penelitian adalah semua kultur darah yang diperiksa pada periode penelitian berjumlah 509.Hasil: Dari 509 sampel spesimen darah, 46 sampel dilaporkan sebagai nilai kritis prediktor bakteremia. Bakteri batang gram negatif teridentifikasi pada 39,13% sampel pewarnaan gram dan 45,65% sampel hasil kultur darah. Bakteri gram positif muncul pada 56,52% sampel pewarnaan gram dan 52,17% sampel hasil kultur darah. Bakteri MDRO (multidrug resistant organisms) teridentifikasi sebanyak 11%, 13% bakteri ESBL (extended spectrum beta lactamase), dan 4% bakteri MRSA (methicillin-resistant Staphylococcus aureus). Proporsi 76% sampel berasal dari pasien non-ICU.Simpulan: Hasil pewarnaan gram dapat digunakan sebagai acuan terapi antibiotika empiris karena memiliki tingkat kesesuaian yang tinggi dengan hasil kultur darah positif.
Terapi non bedah pada karsinoma sel basal
Authors: Santoso Adeline , Darmaputra I Gusti Ngurah , Gotama Dewi , Sissy Sissy 
Published: February 2022

Basal cell carcinoma accounts for approximately 75% of non-melanoma skin cancer and 25% of all diagnosed skin cancer in the United States. Epidemiological data show the incidence is increasing significantly by 3% -10% per year worldwide. Changes in life expectancy patterns are associated with an increase in this skin cancer, and the incidence is predicted to increase until 2040. Many factors must be considered in the choice of therapy for a patient, including the patient's general condition, the presence or absence of serious medical problems, the use of antiplatelet or anticoagulant medication. Conservative treatment of asymptomatic and low-risk lesions is recommended, as overly aggressive therapy may have a greater effect than the lesions themselves. Topical therapy and non-surgical therapy are currently quite effective as therapeutic options for low-risk basal cell carcinoma and high-risk basal cell carcinoma. They can be an option in conditions that are contraindicated for surgery. Kasus keganasan karsinoma sel basal (KSB) mencakup sekitar 75% dari kasus kanker kulit non melanoma dan mencakup 25% dari semua kasus kanker yang didiagnosa di Amerika Serikat.Data epidemiologi menunjukkan insiden meningkat signifikan sebanyak 3%-10% per tahun di seluruh dunia. Perubahan pola usia harapan hidup berhubungan dengan peningkatan kanker kulit ini, dan di prediksi insiden akan terus meningkat sampai tahun 2040. Terdapat banyak faktor yang harus dipikirkan dalam pemilihan terapi pada pasien, antara lain keadaan umum pasien, ada atau tidaknya masalah medis serius, penggunaan obat anti platelet atau anti koagulan. Perawatan konservatif pada lesi asimptomatik dan beresiko rendah dianjurkan, dikarenakan terapi yang terlalu agresif mungkin akan memberikan efek yang lebih besar dibandingkan dengan lesi itu sendiri. Saat ini terapi topikal dan terapi non-bedah dikatakan cukup efektif sebagai pilihan terapi untuk KSB resiko rendah dan KSB resiko tinggi serta dapat menjadi pilihan pada kondisi kontraindikasi terhadap tindakan pembedahan.
Parametrial hematoma following fetal craniotomy and curettage in intrauterine fetal death: a case report
Authors: Vidhisvara Ida Bagus Yudhistira Anantasurya , Widiarsa Ida Bagus Putu , Helena Margaret Gabriele , Himawan I Putu Ivan Cahya 
Published: February 2022

Background: Parametrial hematoma is collection of blood located in the parametrial area, which is a type of hematoma that can occur in the pelvic cavity. Postpartum hematoma is a rare but life-threatening complication of childbirth. Common risk factors to developing parametrial hematomas include multiple pregnancies, traumatic deliveries, operative vaginal delivery, prolonged labour, manual removal of placenta, inadequate hemostasis at Caesarean section, pre-eclampsia, and anticoagulation therapy. We reported a rare case of parametrial hematoma post-craniotomy and curettage of a fetus with intrauterine fetal death (IUFD) in a 28-year-old pregnant woman 24 weeks into her fourth pregnancy. Case report: A pregnant woman with 24 weeks gestation age came to emergency room with complaints of abdominal pain and bloody discharge without clear fluids 9 hours prior. She was diagnosed with preterm delivery and was given tocolytic. The following day, ultrasound examination was done and fetal heart rate (FHR) was not found, suggesting an intrauterine fetal death (IUFD). Termination was carried out with oxytocin induction but due to maternal exhaustion, pain, and lack of cooperation, a craniotomy was done in operating room followed by curettage. Twenty-four hours after curettage, patient complained of an acute lower right abdominal pain and ultrasound showed a complex mass in right adnexa measuring 8 x 8 cm, suggesting a right adnexal hematoma with a differential diagnosis of a right tubo-ovarian abscess. The patient’s haemoglobin was found to decrease to 6.0 g/dl. A laparotomy was performed and a hematoma was found in the right parametrium without active bleeding. Conclusion: Parametrial hematoma is a rare disease that can occur due to trauma (in labor) or spontaneously due to abnormalities of the uterine arteries that supply blood to the uterus. The patient present in this case report had acute abdominal pain with decreased haemoglobin without signs of bleeding after an operative vaginal birth which may or may not be the cause of the parametrial hematoma due to limitations of examination on the patients. Further observation of similar cases will be required to determine the association between parametrial hematoma and operative vaginal birth.
Diagnosa dan Tatalaksana pada Hemoroid Derajat IV: Laporan Kasus
Authors: Indrayani Ni Nyoman Amik , Arnaya Agung Aditya , Wiguna Kevin Kristanto , Wiyasa Ida Bagus Putu 
Published: February 2022

Background : Hemorrhoids affect millions of people around the world and become one of the main medical and socioeconomic problems Hemorrhoids are symptomatic widening of the hemorrhoidal plexus and distal displacement of the normal cushion. This case report aims to discuss cases of hemorrhoids from diagnosis to management.Case Report: A 30-year-old male came with complaints of fresh blood discharge during defecation. Complaints have been felt for 1 month ago and have worsened for 1 day before being admitted to the hospital. On local examination in the anal region, there was a mass with an irregular shape around the anal, some of which were blackish red in color and partly the same color as the surrounding skin with a diameter of 3 cm. On palpation, the mass was palpable, firm, tenderness, the mass could not be given with a finger. Based on the history and physical examination, the patient was diagnosed with grade IV internal hemorrhoids and an open hemorrhoidectomy (Miligan-Morgan method) was planned.Conclusion: The diagnosis of hemorrhoids is obtained from the patient's medical history, physical examination and supporting examinations. Therapeutic management of hemorrhoids can be in the form of animation and surgery. Latar Belakang : Hemoroid mengenai jutaan orang diseluruh dunia dan menjadi salah satu masalah medis utama dan masalah sosioekonomi Hemoroid adalah pelebaran simptomatis dari pleksus hemoroid dan pergeseran bantalan anus ke arah distal dari normal. Laporan kasus ini bertujuan untuk membahas kasus hemoroid dari diagnosa sampai dengan tatalaksananya.Laporan Kasus: Seorang laki-laki usia 30 tahun datang dengan keluhan keluar darah berwarna merah segar saat buang air besar. Keluhan dirasakan sejak 1 bulan yang lalu dan memberat sejak 1 hari sebelum masuk rumah sakit. Pada pemeriksaan lokalis di regio anal terlihat adanya benjolan dengan bentuk iregular mengitari anus yang sebagian berwarna merah kehitaman dan sebagian sama dengan warna kulit disekitarnya dengan ukuran diameter 3 cm. Saat dilakukan palpasi didapatkan benjolan teraba kenyal, batas tegas, nyeri tekan (+) benjolan tidak dapat dimasukkan dengan jari. Berdasarkan dari anamnesa dan pemeriksaan fisik, pasien kemudian didiagnosa dengan Hemorroid interna grade IV dan ditangani dengan metode open hemorrhoidectomy (Miligan-Morgan Method). Pasien dirawat selama dua hari dimana pasien sudah bisa buang air besar tetapi masih terasa nyeri namun benjolan sudah tidak terlihat dari anus.Simpulan: Hemoroid dapat didiagnosa dari riwayat medis pasien, pemeriksaan fisik serta pemeriksaan penunjang. Manajemen terapi pada hemoroid dapat berupa konservatif dan operasi.
Phosphorus-Calcium and Bone Metabolism in Children with Dystrophic Epidermolysis Bullosa: Cross-Sectional Study
Authors: Pronina Irina Yu. , Murashkin Nikolay N. , Makarova Svetlana G. , Vershinina Marina G. , Semikina Elena L. , Mavrikidi Elena F. 
Published: February 2022

Background. Dystrophic epidermolysis bullosa (EB) is a rare skin disease, and secondary osteoporosis is one of its complications. The bone remodeling condition in this pathology has not been studied enough. Objective. The aim of the study is to study the characteristics of phosphorus-calcium and bone metabolism in children with dystrophic EB.Methods. The study included children with dystrophic EB aged from 3 to 18 years undergoing inpatient treatment. The ratio of children with phosphorus-calcium metabolism disorders was determined: reduced concentration of total calcium < 2.2 mmol/l, and phosphorus < 1.25 mmol/l. Additionally, deviations from reference values for 25(OH)D, parathormone, osteocalcin, C-terminal telopeptide of type 1 collagen (CTX-I) concentrations and alkaline phosphatase activity were established.Results. Hypocalcemia was revealed in 16 patients (41%) and hypophosphatemia — in 3 (8%) patients out of 39 children with EB (22 girls, median age 77 (46; 136) months). Vitamin D level was lower than optimal (< 30 ng/ml) in 20 (77%) children with EB, while lower osteocalcin concentration — in 26 (67%), and lower CTX-I concentration — in all patients. At the same time, the median CTX-I concentration (1.32 ng/ml) more than doubled the upper values of the reference range for this indicator (< 0.573 and < 0.584 ng/ml for girls and boys, respectively). The low parathormone concentration was revealed in 1 (3%) patient. The alkaline phosphatase activity was within the reference range in all cases.Conclusion. Disorders of phosphoruscalcium (mainly calcium) metabolism are present in large number of children with dystrophic EB. Therewith, most patients have shown vitamin D deficiency, as well as signs of bone resorption dominance (high CTX-I concentration) over bone development (low osteocalcin concentration). In general, all revealed changes in the biochemical indicators of bone remodeling indicate the development of secondary osteoporosis in most children with EB.