bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived Changes of Attitudes and Behaviors of Seventh-Day Adventists During the COVID-19 Pandemic: Findings from a Cross-Sectional Survey in Germany
Authors: Büssing Arndt , Recchia Daniela Rodrigues , Starck Lorethy , van Treeck Klaus 
Published: May 2022

AbstractTo analyze which pandemic related changes of attitudes and behaviors were perceived by Seventh-day Adventists (SDA) and how these relate to wellbeing, a cross-sectional survey with standardized questionnaires was performed. Participants (n = 1,494) stated changes for Relationships, Digital media usage and Nature/Silence/Contemplation, but not for Spirituality or Reflection of life. Best predictors of psychological wellbeing (WHO-5) were Spiritual wellbeing, perceived Restrictions and Awe/Gratitude (R2 = .32). Mediation analyses (R2 = 0.51) revealed a mediation effect of Awe/Gratitude between spiritual to psychological wellbeing (β = 0.11, p < 0.0001). Perceived changes were less relevant to buffer the negative effects of the pandemic; instead, they were related to fears of future. More relevant to stabilize SDAs´ wellbeing was their spirituality.
Perpetual American Double Lookback Options on Drawdowns and Drawups with Floating Strikes
Authors: Gapeev Pavel V. 
Published: May 2022

AbstractWe present closed-form solutions to the problems of pricing of the perpetual American double lookback put and call options on the maximum drawdown and the maximum drawup with floating strikes in the Black-Merton-Scholes model. It is shown that the optimal exercise times are the first times at which the underlying risky asset price process reaches some lower or upper stochastic boundaries depending on the current values of its running maximum or minimum as well as the maximum drawdown or maximum drawup. The proof is based on the reduction of the original double optimal stopping problems to the appropriate sequences of single optimal stopping problems for the three-dimensional continuous Markov processes. The latter problems are solved as the equivalent free-boundary problems by means of the smooth-fit and normal-reflection conditions for the value functions at the optimal stopping boundaries and the edges of the three-dimensional state spaces. We show that the optimal exercise boundaries are determined as either the unique solutions of the associated systems of arithmetic equations or the minimal and maximal solutions of the appropriate first-order nonlinear ordinary differential equations.
Multidimensional frailty and quality of life: data from the English Longitudinal Study of Ageing
Authors: Veronese Nicola , Noale Marianna , Cella Alberto , Custodero Carlo , Smith Lee , Barbagelata Marina , Maggi Stefania , Barbagallo Mario , Sabbà Carlo , Ferrucci Luigi , Pilotto Alberto 
Published: May 2022

Abstract
Purpose
Frailty has been found to be associated with poor quality of life (QoL) in older people, but data available are limited to cross-sectional studies. We therefore aimed to assess the association between multidimensional frailty, determined by Multidimensional Prognostic Index (MPI), with mortality and good QoL expectancy (GQoLE) in a large representative sample of older adults, over 10 years of follow-up.

Methods
In the English Longitudinal Study of Ageing, using the data from 2004–2005 and 2014–2015, MPI was calculated using a weighted score of domains of comprehensive geriatric assessment, i.e., number of difficulties in activities of daily living (ADL) and instrumental ADL, depressive symptoms, number of medical conditions, body mass index, physical activity level, and social aspects. Mortality was assessed using administrative data, GQoLE indicators were used for longitudinal changes in QoL.

Results
6244 Participants (mean age 71.8 years, 44.5% males) were followed up for 10 years. After adjusting for potential confounders, compared to people in the MPI low-risk group, people in the moderate (hazard ratio, HR = 4.27; 95% confidence interval, CI 3.55–5.14) and severe-risk group (HR = 10.3; 95% CI 7.88–13.5) experienced a significantly higher mortality rate. During the follow-up period, people in the moderate and severe-risk groups reported lower GQoLE values than their counterparts, independently from age and gender.

Conclusions
Multidimensional frailty was associated with a higher risk of mortality and significantly lower GQoLE, suggesting that the multifactorial nature of frailty is associated not only with mortality, but also poor QoL.
Embedded Nano Relay for Intra-Body Network-Based Molecular Communications
Authors: Abd El-atty Saied M. , Bidar Reda , El-Rabaie El-Sayed M. 
Published: May 2022

AbstractWe propose an embedded synthetic relay transport protein (RTP) approach for communication between the external environment (blood vessels) and internal targeted nanonetworks (cells/tissues) within the intra-body network. In fact, we designed a bioengineered relay protein-based facilitated diffusing to be an alternative protein in the case of biological transport proteins (such as protein channels, e.g. Pores) failing. The proposed approach is inspired by the traditional wireless communication system-based relay concept, in which embedded nanodevices known as donor, relay, and acceptor bionanomachine construct a molecular communication system. Fluorescence resonance energy transfer nanocommunications are used to connect the embedded bionanomachines, and the therapeutic drug is transferred in the form of exciton. The performance analysis of the proposed approach is evaluated in terms of channel capacity of RTP as function of intrinsic environmental parameters and the location of the relay between the donor, and acceptor bionanomachines. The numerical results show that the proposed approach improves channel capacity by 16.7% over previous work.
Generalised exponential-Gaussian distribution: a method for neural reaction time analysis
Authors: Marmolejo-Ramos Fernando , Barrera-Causil Carlos , Kuang Shenbing , Fazlali Zeinab , Wegener Detlef , Kneib Thomas , De Bastiani Fernanda , Martinez-Flórez Guillermo 
Published: May 2022

AbstractReaction times (RTs) are an essential metric used for understanding the link between brain and behaviour. As research is reaffirming the tight coupling between neuronal and behavioural RTs, thorough statistical modelling of RT data is thus essential to enrich current theories and motivate novel findings. A statistical distribution is proposed herein that is able to model the complete RT’s distribution, including location, scale and shape: the generalised-exponential-Gaussian (GEG) distribution. The GEG distribution enables shifting the attention from traditional means and standard deviations to the entire RT distribution. The mathematical properties of the GEG distribution are presented and investigated via simulations. Additionally, the GEG distribution is featured via four real-life data sets. Finally, we discuss how the proposed distribution can be used for regression analyses via generalised additive models for location, scale and shape (GAMLSS).
The 3 Wishes Program Improves Families’ Experience of Emotional and Spiritual Support at the End of Life
Authors: Neville Thanh H. , Taich Zachary , Walling Anne M. , Bear Danielle , Cook Deborah J. , Tseng Chi-Hong , Wenger Neil S. 
Published: May 2022

Abstract
Background
The end-of-life (EOL) experience in the intensive care unit (ICU) is emotionally challenging, and there are opportunities for improvement. The 3 Wishes Program (3WP) promotes the dignity of dying patients and their families by eliciting and implementing wishes at the EOL.

Aim
To assess whether the 3WP is associated with improved ratings of EOL care.

Program Description
In the 3WP, clinicians elicit and fulfill simple wishes for dying patients and their families.

Setting
2-hospital academic healthcare system.

Participants
Dying patients in the ICU and their families.

Program Evaluation
A modified Bereaved Family Survey (BFS), a validated tool for measuring EOL care quality, was completed by families of ICU decedents approximately 3 months after death. We compared patients whose care involved the 3WP to those who did not using three BFS–derived measures: Respectful Care and Communication (5 questions), Emotional and Spiritual Support (3 questions), and the BFS-Performance Measure (BFS-PM, a single-item global measure of care).

Results
Of 314 completed surveys, 117 were for patients whose care included the 3WP. Bereaved families of 3WP patients rated the Emotional and Spiritual Support factor significantly higher (7.5 vs. 6.0, p = 0.003, adjusted p = 0.001) than those who did not receive the 3WP. The Respectful Care and Communication factor and BFS-PM were no different between groups.

Discussion
The 3WP is a low-cost intervention that may be a feasible strategy for improving the EOL experience.
Particle Vibration, an Instrument to Study Particle Accumulation Structures On Board the International Space Station
Authors: Lappa Marcello , Burel Thomas , Kerr Monica , Crewdson Georgie , Boaro Alessio , Capobianchi Paolo , Bonnieu Sebastien Vincent , Murphy Lesley , Randall Peter , Hens Steven 
Published: May 2022

AbstractThe scientific and technological aspects of the PARTICLE VIBRATION Project (also known as T-PAOLA i.e. “Thermovibrationally-driven Particle self-Assembly and Ordering mechanisms in Low grAvity”) are described in detail. The project relies on the combined use of the Selectable Optical Diagnostics Instrument (SODI), a Class-2 device developed by ESA for scientific experiments in the field of fluids on board the International Space Station, and the Microgravity Science Glovebox (MSG), a Class-1 general purpose facility under the responsibility of NASA. The related modular architecture has recently been expanded under the umbrella of new scientific research funded by the UK Space Agency to allow for a novel class of experiments dealing with multiphase (solid-liquid) flows. The final aim of this microgravity project is the identification of new dispersed-phase self-organization phenomena driven by the application of vibrations and the ensuing development of new contactless particle manipulations strategies. In the present paper, emphasis is given to the related space hardware and software, the experiment protocol, the ground tests and procedures and all the adaptations that had to be implemented to overcome a number of technological and physical issues, both general and system-specific.
Symptomatic Care in Multiple System Atrophy: State of the Art
Authors: Grossauer Anna , Sidoroff Victoria , Heim Beatrice , Seppi Klaus 
Published: May 2022

Abstract
Without any disease-modifying treatment strategy for multiple system atrophy (MSA), the therapeutic management of MSA patients focuses on a multidisciplinary strategy of symptom control. In the present review, we will focus on state of the art treatment in MSA and additionally give a short overview about ongoing randomized controlled trials in this field.
Provenance of Mesozoic sandstones from the northwestern Gulf of Suez, Egypt: new evidence from petrography and whole-rock geochemistry
Authors: Sallam Emad S. , Garzanti Eduardo , Li Xianghui , Ruban Dmitry A. 
Published: May 2022

AbstractNew investigations of petrographic and geochemical characteristics of Mesozoic sandstones from the northwestern Gulf of Suez in Egypt have been undertaken, documenting dominance of quartzose sandstones containing on average ~ 5% of mostly sedimentary and subordinately metamorphic lithic fragments (siltstone, sandy siltstone, and, more rarely slate, metasiltstone, limestone, dolostone, quartz-muscovite schist, and gneiss). These sandstones are depleted in many chemical elements and display low Al2O3/SiO2 and K2O/Na2O ratios. Mineralogical and geochemical parameters point at extensive recycling from older (i.e., Paleozoic) siliciclastic strata. Relatively constant composition throughout the Mesozoic contrasts with successive palaeogeographic changes associated to the major events of rifting and dispersal, which may be explained by the widespread distribution of Paleozoic clastic wedges all across northern Gondwana.
Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNA
Authors: Zhang Le , Su Xiulan 
Published: May 2022

Abstract
Purpose
N6-methyladenosine (m6A), the most prevalent mRNA modification, plays an essential role in tumorigenesis. Notably, increasing interest has been directed to bioactive peptides (BPs) with antitumor activities. Here, we set out to investigate the potential of the BP-regulated ALKBH5/MLST8/EIF4EBP1 axis on prevention and treatment of acute myeloid leukemia (AML).

Methods
The biological effects of BP on AML cells were detected by MTT and ApoLive-Glo™ multiplex assays. The role of BP in tumor growth was determined by a subcutaneous xenograft model. The ALKBH5/MLST8/EIF4EBP1 axis was identified as a potential BP target in AML via methylated RNA immunoprecipitation sequencing (MeRIP-seq) combined with RNA sequencing (RNA-seq). Western blot, RT-qPCR, MeRIP-qPCR, dual-luciferase reporter and RNA stability assays were performed to validate the function and mode of action of the BP-regulated ALKBH5/MLST8/EIF4EBP1 axis. The clinical relevance of the BP-regulated ALKBH5/MLST8/EIF4EBP1 axis in AML was confirmed by TCGA data analysis.

Results
We found that BP can inhibit AML cell proliferation and promote apoptosis in vitro, and repress AML tumor growth in vivo. Mechanistically, we found that BP downregulated ALKBH5 expression, which in turn repressed m6A demethylation of MLST8 and EIF4EBP1 mRNAs. Reduction of the m6A levels of MLST8 and EIF4EBP1 facilitated MLST8 and EIF4EBP1 mRNA decay, resulting in inhibition of AML cell proliferation. Furthermore, we found that the BP-regulated ALKBH5/MLST8/EIF4EBP1 axis closely correlates with AML patient prognosis.

Conclusions
Our data indicate that BP can inhibit acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNAs, which may have potential to prevent and treat this disease.
Erratum to: Si-based polymer-derived ceramics for energy conversion and storage
Authors: Wen Qingbo , Qu Fangmu , Yu Zhaoju , Graczyk-Zajac Magdalena , Xiong Xiang , Riedel Ralf 
Published: May 2022

AbstractBesides the original acknowledgements, the authors Ralf Riedel and Magdalena Graczyk-Zajac would like to also acknowledge EU support in the frame of H2020 project SIMBA under grant agreement number 963542.
Updating obesity management strategies: an audit of Italian specialists
Authors: Busetto Luca , Carbonelli Maria Grazia , Caretto Antonio , Colao Annamaria , Cricelli Claudio , De Luca Maurizio , Giorgino Francesco , Gnessi Lucio , Medea Gerardo , Pappagallo Giovanni , Santini Ferruccio , Sbraccia Paolo , Zappa Marco Antonio 
Published: May 2022

AbstractObesity negatively affects physical and psychological health and increases health care costs. Although there is increasing interest in early diagnosis and timely intervention, there are several principles of care included in the current guidelines for clinical management of obesity that can potentially be updated and improved to address the “clinical inertia” and, consequently, to optimize the management of adult obesity. Using an online Delphi-based process, an Italian board of experts involved in the management of obesity discussed the usefulness of a pro-active approach to the care of patients with obesity, providing a consensus document with practical indications to identify risk factors for morbidity and death and raise awareness throughout the treatment continuum, including the early stages of the disease. In clinical practice, it seems inappropriate to delay an intervention that could avoid progression to a more severe level of obesity and/or prevent the onset of obesity-related comorbidities.Level of evidence Level V, report of expert committee.
I tumori neuroendocrini ben differenziati di grado 3 del pancreas: definizione e gestione clinica
Authors: Sparano Clotilde , Petrone Luisa , Maggi Mario , Antonuzzo Lorenzo 
Published: May 2022

SommarioI tumori neuroendocrini di grado 3 rappresentano una recente entità patologica con caratteristiche intermedie tra i carcinomi neuroendocrini e i tumori neuroendocrini a basso grado. Il pancreas rappresenta il primo organo in cui questa nuova categoria è stata identificata e riguardo alla quale si dispongono di maggiori evidenze cliniche. Emergenti peculiarità scintigrafiche e terapeutiche rendono questo sottogruppo di neoplasie attuale oggetto di studio, nell’ottica di una futura e consapevole personalizzazione del percorso di cura.
Hunting the pertinency of hash and bloom filter combinations on GPU for fast pattern matching
Authors: Bhat Radhakrishna , Thilak Reddy Kanala , Vaibhav Reddy Panyala 
Published: May 2022

AbstractThere has been rapid growth in the field of graphical processing unit (GPU) programming due to the drastic increase in the computing hardware manufacturing. The technology used in these devices is now more affordable and accessible to the general public. With this growth, many serial programming applications that are now being transformed into more efficient parallel programming applications with significant improvement in the performance. The best example for this is parallel implementation of the probabilistic data structure Bloom filter in set membership queries. However, despite of it’s remarkable performance in speed and memory usage, there is a computational overhead in the calculation of hashes in Bloom filter. In this paper, the impact of the choice of hash functions on the qualitative properties of the Bloom filter has been experimentally recorded and the results show that there is a possibility of large performance gap among various hash functions. We have implemented the Bloom filter based pattern matching technique on GPU using compute unified device architecture (CUDA) and benchmark the performance of several cryptographic and non-cryptographic hash functions.
Was bleibt übrig vom Kindergarten? Zur Entwicklung des Kindergartens im Kanton Bern nach dem Zweiten Weltkrieg
Authors: Schmid Elias 
Published: May 2022

ZusammenfassungNach dem Zweiten Weltkrieg näherte sich der Kindergarten des Kantons Bern kontinuierlich der Primarschule an. Bis in die Gegenwart kam es zur strukturellen, professionellen und curricularen Integration. Gegenstand des Artikels sind ebendiese Annäherungs- und Integrationsprozesse, dargestellt anhand von Schul- und Kindergartenerlassen, amtlichen Berichten, Lehrplänen und ausgewählten Forschungsergebnissen. Wie die Prozesse einzuschätzen sind, wird im Diskussionsteil erörtert: Wurde der Kindergarten verschult? Die Primarschule verkindergartet? Was ist eigentlich neu an der Eingangsstufe?
RNA2Immune: A Database of Experimentally Supported Data Linking Non-Coding RNA Regulation to the Immune System
Authors: Wang Jianjian , Li Shuang , Wang Tianfeng , Xu Si , Wang Xu , Kong Xiaotong , Lu Xiaoyu , Zhang Huixue , Li Lifang , Feng Meng , Ning Shangwei , Wang Lihua 
Published: May 2022

Abstract
Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as important regulators of the immune system and are involved in the control of immune cell biology, disease pathogenesis, as well as vaccine responses. A repository of ncRNA–immune associations will facilitate our understanding of ncRNA-dependent mechanisms in the immune system and advance the development of therapeutics and prevention for immune disorders. Here, we describe a comprehensive database, RNA2Immune, which aims to provide a high-quality resource of experimentally supported database linking ncRNA regulatory mechanisms to immune cell function, immune disease, cancer immunology, and vaccines. The current version of RNA2Immune documents 50,433 immune–ncRNA associations in 42 host species, including (1) 6690 ncRNA associations with immune functions involving 31 immune cell types; (2) 38,672 ncRNA associations with 348 immune diseases; (3) 4833 ncRNA associations with cancer immunology; and (4) 238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 diseases. RNA2Immune provides a user-friendly interface for browsing, searching, and downloading ncRNA–immune system associations. Collectively, RNA2Immune provides important information about how ncRNAs influence immune cell function, how dysregulation of these ncRNAs leads to pathological consequences (immune diseases and cancers), and how ncRNAs affect immune responses to vaccines. RNA2Immune is available at http://bio-bigdata.hrbmu.edu.cn/rna2immune/home.jsp.
Constitutional Statecraft in Malaysian Courts: A Naive ‘Schmittian’ Misappropriation
Authors: Balasubramaniam R. Rueban 
Published: May 2022

AbstractIn her recent book, Constitutional Statecraft in Asian Courts, Yvonne Tew develops an ambitious argument for empowering Malaysian judges to promote constitutional democracy. Her arguments rely on the idea of an unamendable constitutional ‘basic structure’ or ‘meta-Constitution’ expressive of that ideal. I argue that her proposals are normatively inadequate to this task because Tew relies on resources in constitutional theory traceable to the conservative German thinker Carl Schmitt, whose views about constitutional legitimacy and limits to constitutional amendment form part of an authoritarian political logic designed to subvert constitutional democracy that subordinates legality to power politics. I then argue that Tew's proposals, if applied to Malaysia, risk feeding into elements of Schmittian authoritarian logic that plausibly underwrite Malaysia's ethnocratic context, and conjecture (through case-analysis) that authoritarian judges could easily reconfigure her proposals to legitimate ethno-authoritarian rule. Conversely, conscientious judges who defend constitutional democracy would adopt a non-Schmittian approach that emphasises the normative priority of legality as a constraint on political power to counter ethno-authoritarian rule. Consequently, despite Tew's aspiration to equip judges with tools to defend constitutional democracy, the tools she provides threaten to undermine this aspiration such that her proposals may be characterised as a naïve Schmittian misappropriation.
On the Sn/n problem
Authors: Christensen Sören , Fischer Simon 
Published: May 2022

AbstractThe Chow–Robbins game is a classical, still partly unsolved, stopping problem introduced by Chow and Robbins in 1965. You repeatedly toss a fair coin. After each toss, you decide whether you take the fraction of heads up to now as a payoff, otherwise you continue. As a more general stopping problem this reads
$V(n,x) = \sup_{\tau }\mathbb{E} \left [ \frac{x + S_\tau}{n+\tau}\right]$
, where S is a random walk. We give a tight upper bound for V when S has sub-Gaussian increments by using the analogous time-continuous problem with a standard Brownian motion as the driving process. For the Chow–Robbins game we also give a tight lower bound and use these to calculate, on the integers, the complete continuation and the stopping set of the problem for
$n\leq 489\,241$
.