bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОСВІТНІЙ ПОТЕНЦІАЛ ЕЛЕКТРОННИХ ВИСТАВОК ІСТОРИКО-КУЛЬТУРНИХ ФОНДІВ НАУКОВОЇ БІБЛІОТЕКИ
Authors: Курганова Олена Юріївна , Лобузіна Катерина Вілентіївна 
Published: July 2022

У статті розглянуто цифровий ресурс «Електронні виставки» Національної бібліотеки України імені В. І. Вернадського (НБУВ) у контексті розвитку інструментів дистанційного навчання та самоосвіти. Спричинені карантинними заходами та воєнним станом обмеження фізичного доступу українських студентів до першоджерел наукової інформації значно актуалізували дослідження інформаційно-освітнього потенціалу електронних ресурсів, створених провідними фахівцями установ-фондоутримувачів історико-культурної спадщини. Висвітлений у численних публікаціях практичний досвід виставкової діяльності бібліотек засвідчує високу суспільно-освітню користь електронних експозицій оригіналів архівних документів, рукописів, стародруків, рідкісних книг, періодичних та нотних видань, творів мистецтва тощо. Пропонована стаття вперше розкриває тематику всього комплексу електронних виставок НБУВ, що налічує понад 700 окремих експозицій. Науковою новизною дослідження є порівняльний аналіз ресурсів електронних експозицій великих бібліотек України та світу, що дозволив зробити висновок про безпрецедентну активність, високий інформаційно-освітній та культурно-історичний потенціал виставкової діяльності НБУВ. У статті підкреслено, що на відміну від загальних інформаційних ресурсів бібліотек, які розкривають наповнення фонду та надають дистанційний доступ до цифрових копій документів, електронні експозиції історико-культурних фондів НБУВ висвітлюють результати досліджень певної наукової теми, відповідно, до підготовки вербального та візуального контенту таких виставок залучено вчених-гуманітаріїв. Поданий у статті огляд тематики електронних виставок історико-культурних фондів НБУВ засвідчує актуальність цього ресурсу в якості ефективного інструменту для дистанційного навчання та самоосвіти майбутніх фахівців з інформаційної, бібліотечної та архівної справи, представників усіх спеціальностей гуманітарного спрямування та поліграфістів, а також у якості доповнення загальноосвітніх курсів з історії української та світової культури.
MODELLING OF PEDAGOGICAL PATTERNS THROUGH E-LEARNING OBJECTS
Authors: Hristov Hristo , Yonchev Emil , Tsvetkov Vladimir 
Published: July 2022

Software platforms for e-learning support various options for presenting educational content. One of the ways to organize and structure it is via so-called pedagogical patterns. They are a method for describing and sharing knowledge and practical experience. Pedagogical patterns are used to describe pedagogical situations that occur repeatedly in the learning process. In the context of e-learning systems, there are various approaches to digitalization of pedagogical patterns. The purpose of the paper is to show how to build instances of pedagogical patterns using e-learning pedagogical objects, which can be easily and conveniently used as models in an adaptive e-learning environment. An e-learning pedagogical object is an abstract concept that can be presented in the concrete form of an e-learning object, an e-learning methodological object, an e-learning object for monitoring and diagnostics or an e-learning object with learning outcomes. These objects are building blocks for constructing instances of pedagogical patterns. This paper thoroughly discusses the issue of creating instances of pedagogical patterns of the four types of e-learning pedagogical objects. The instance of a pedagogical pattern is meant to serve to create subsections of educational topics. The instances of the patterns built of e-learning objects are learning units that are used depending on the context of a particular pedagogical situation.
The e-learning pedagogical objects and the pedagogical pattern instances are intended to be applied in an adaptive e-learning environment as teaching aids. Their theoretical models are applied in Moodle LMS in line with the tendency for software to assist and replace some of the teacher functions, while the teacher’s role is raised to a higher organizational, pedagogical and methodological level.
Three instances of pedagogical patterns have been created through e-learning pedagogical objects: “Early Feedback”, “Feedback Sandwich” and “Consistent Metaphor” in LMS Moodle, which have been tested in the training course “Modeling of training courses in Moodle” during the autumn trimester of the academic year 2021/2022 at the Faculty of Mathematics and Informatics of Paisii Hilendarski University of Plovdiv, Bulgaria.
Pengaruh Waktu Paparan Pestisida Organofosfat Terhadap Kadar Kolinesterase Dalam Darah Dengan Metode Komperator
Authors: Mayaserli Dyna Putri , Rosita Betti , Remadhani Eni 
Published: July 2022

World Health Organization (WHO) memperkirakan kasus keracunan pada pekerja pertanian karena pestisida sebanyak 1-5 juta orang per tahun dan tingkat kematian mencapai 220.000 korban jiwa. Paparan pestisida bertindak sebagai senyawa asetilkolinesterase (Ach), yang mengurangi aktivitas kolineterase dalam darah. Kolinesterase adalah salah satu bentuk enzim yang berasal dari katalis biologis dalam jaringan manusia yang berperan membantu otot dan kelenjar saraf bekerja secara teratur dan harmonis. Jika aktivitas kolinesterase jaringan manusia dikurangi dengan baik ke tingkat lebih rendah, hal ini akan mempengaruhi gerakan sadar atau kasar dari serat otot. Tujuan penelitian ini adalah untuk mengetahui kadar kolinesterase dalam darah menggunakan metoda komperator (kaca pembanding) pada petani sayur berdasarkan lama paparan pestisida organofosfat. Metode yang dilakukan pada penelitian ini adalah deskriptif dengan menggunakan 20 sampel. Berdasarkan dari uji statistik didapatkan nilai sig 0,003 < 0,05 yang artinya bahwa perbedaan kadar kolinesterase berdasarkan lama paparan pestisida pada petani sayur di Kabupaten Solok memiliki perbedaan atau adanya pengaruh sebesar 0,621 nilai tersebut setelah dikonsultasi dengan tabel interprestasi angka “r” (pedoman derajad hubungan) 0,621 berada antara (0,60-0,799) yang interprestasinya termasuk dalam kategori kuat.
Analisis Zat Gizi dan Uji Organoleptik pada Jus (Belsem) Belimbing Semangka sebagai Minuman bagi Penderita Hipertensi
Authors: Yensasnidar Yensasnidar , Adfar Tika Dwita , Ilham Pionir Wira 
Published: July 2022

Prevalensi hipertensi di Indonesia adalah sebesar 34,11%, penyakit hipertensi disebabkan oleh makanan yang dikonsumsi oleh masyarakat. Pola hidup sehat dan pola makan yang sehat merupakan pilihan yang tepat untuk menjaga diri terbebas dari tekanan darah tinggi. Tujuan penelitian untuk menganalisis zat gizi dan uji organoleptik jus (belsem) Belimbing Semangka untuk pencegahan hipertensi. Jenis penelitian adalah penelitian eksperimen, uji organoleptik dilakukan di laboratorium makanan Universitas Perintis Indonesia dan analisis zat gizi di Laboratorium Kimia Universitas Negeri Padang. Pengamatan subjektif yang dilakukan uji kesukaan dan mutu hedonik dengan 25 orang panelis. Metode penelitian eksperimen dalam bentuk rancangan acak lengkap (RAL) dengan 1 kontrol 3 perlakuan. Analisis uji statistic menggunakan analisa one way anova (ANOVA) pada tarif 5%, Jika terdapat perbedaan antar perlakuan, dilanjutkan degan uji Duncan new multiple range test (DNMART) pada taraf 5%. Hasil penelitian ini menunjukan bahwa jus belimbing dengan penambahan semangka 50gr merupakan jus yang paling disukai panelis. Setelah itu dilakukan analisis zat gizi dengan vitamin A sebanyak 76,4mg/100gr, vitamin C sebanyak 233,2mg/100gr dan kalium sebanyak 8.902mg/100gr. Disarankan pada peneliti selanjutnya untuk melakukan penelitian jus (belsem) Belimbing Semangka dengan sasaran panelis langsung kepada masyarakat yang hipertensi sehingga dapat mengetahi pengaruh pemberian jus (belsem) belimbing semangka sebagai pencegahan hipertensi
Full-Scale of a Compost Process Using Swine Manure, Human Feces, and Rice Straw as Feedstock
Authors: Gao Yi , Zhang Chunxue , Tan Lu , Wei Xiaocheng , Li Qian , Zheng Xiangqun , Liu Fang , Wang Jiarui , Xu Yan 
Published: July 2022

Regarding the composting of rural waste, numerous studies either addressed the composting of a single waste component or were conducted at a laboratory/pilot scale. However, far less is known about the mixed composting effect of multi-component rural waste on a large scale. Here, we examined nutrient transformation, maturity degree of decomposition, and succession of microbial communities in large-scale (1,000 kg mixed waste) compost of multi-component wastes previously optimized by response models. The results showed that multi-component compost can achieve the requirement of maturity and exhibit a higher nutritional value in actual compost. It is worth noting that the mixed compost effectively removed pathogenic fungi, in which almost no pathogenic fungi were detected, and only two pathogenic bacteria regrown in the cooling and maturation stages. Structural equation models revealed that the maturity (germination index and the ratio of ammonium to nitrate) of the product was directly influenced by compost properties (electrical conductivity, pH, total organic carbon, moisture, temperature, and total nitrogen) compared with enzymes (cellulase, urease, and polyphenol oxidase) and microbial communities. Moreover, higher contents of total phosphorus, nitrate-nitrogen, and total potassium were conducive to improving compost maturity, whereas relatively lower values of moisture and pH were more advantageous. In addition, compost properties manifested a remarkable indirect effect on maturity by affecting the fungal community (Penicillium and Mycothermus). Collectively, this evidence implies that mixed compost of multi-component rural waste is feasible, and its efficacy can be applied in practical applications. This study provides a solution for the comprehensive treatment and utilization of rural waste.
Hybrid Reconnaissance Mission to the 30 October 2020 Aegean Sea Earthquake and Tsunami (Izmir, Turkey & Samos, Greece): Description of Data Collection Methods and Damage
Authors: Aktas Yasemin D. , Ioannou Ioanna , Malcioglu Fatma Sevil , Kontoe Maria , Parammal Vatteri Ahsana , Baiguera Marco , Black Jacob , Kosker Anil , Dermanis Panagiotis , Esabalioglou Martha , Cabuk Eser , Donmez Kokcan , Ercolino Marianna , Asinari Mariana , Verrucci Enrica , Putrino Valentina , Durmaz Bahar , Kazantzidou-Firtinidou Danai , Cotton Dave , O’Kane Aisling , Ozden Ali Tolga , Contreras Diana , Cels Jonas , Free Matthew , Burton Paul , Wilkinson Sean , Rostami Rohollah , D’Ayala Dina 
Published: July 2022

On 30 October 2020, an earthquake of Mw 6.9 hit the Aegean coasts of Turkey and Greece. The epicentre was some 14 km northeast of Avlakia on Samos Island, and 25 km southwest of Seferihisar, Turkey, triggering also a tsunami. The event has been followed by &gt;4,000 aftershocks up to Mw 5.2 The Earthquake Engineering Field Investigation Team (EEFIT) has immediately gathered a team to conduct a hybrid reconnaissance study, bringing together remote and field investigation techniques. The mission took place between 16 November and 17 December, inclusive of three sets of field study carried out by the field crews for building damage assessment in the affected areas in Turkey and Greece under the coordination of the remote team. The mission also aimed to assess the viability of alternative data sources for an appraisal of the future viability of hybrid missions. This paper summarises the mission setup and findings, and discusses the benefits of and difficulties encountered during this hybrid reconnaissance activity.
Design of a Novel Series of Hetero-Binuclear Superhalogen Anions MM′X4− (M = Li, Na; M′ = Be, Mg, Ca; X = Cl, Br)
Authors: Yang Hui , He Hui-Min , Li Ning , Jiang Shang , Pang Min-Jun , Li Ying , Zhao Jian-Guo 
Published: July 2022

A series of hetero-binuclear superatom motifs involving chloride/bromide ligands, that is, MM′X4− (M = Li, Na; M′ = Be, Mg, Ca; X = Cl, Br) anions, have been characterized by using many-body perturbation theory calculations. Large vertical electron detachment energies (VDEs, 5.470–6.799 eV) confirm the superhalogen identity of these anions. A larger VDE value can be obtained by introducing small M or large M′ central atoms and small halogen ligand atoms. Thus, one isomer of LiCaCl4− possesses the largest VDE value. Besides, when the extra electron is shared by all ligand atoms or three bridging ligand atoms, the isomers have relatively larger VDE values.
Methylene Blue–Mediated Antimicrobial ​Photodynamic Therapy Against Clinical Isolates of Extensively Drug Resistant ​Gram-Negative Bacteria Causing Nosocomial Infections in Thailand, An In Vitro Study
Authors: Songsantiphap Chankiat , Vanichanan Jakapat , Chatsuwan Tanittha , Asawanonda Pravit , Boontaveeyuwat Einapak 
Published: July 2022

Background/PurposeSome multidrug-resistant gram-negative bacteria as a global threat have been recently prioritized for research and development of new treatments. We studied the efficacy of methylene blue–mediated antimicrobial photodynamic therapy (MB-aPDT) for the reduction of extensively drug-resistant Acinetobacter baumannii (XDR-AB) and Pseudomonas aeruginosa (XDR-PS) and multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolated in a university hospital setting in Thailand.MethodTwo isolates of each selected bacterium were collected, XDR-AB1 and AB2, XDR- PS1 and PS2, and MDR-KP1 and KP2. Three triplicate experiments using various MB concentrations alone, various red light fluences alone, as well as the selected non-toxic doses of MB and fluences of red light combined as MB-aPDT were applied on each selected isolate. The colonies were counted [colony forming units (CFU)/ml]. Estimation of the lethal treatment dose defined as reduction of &gt; 2 log10 in CFU/ml compared with untreated bacteria.ResultThere were generally negligible changes in the viable counts of the bacterial suspensions treated with all the MB concentrations (p &gt; 0.05). In the second experiment with the only red light treatments, at fluences higher than 2 J/cm, reduction trend in viable counts across all the isolates was observed. Only for MDR-KP1, however, the lethal dose was achieved with the highest fluence of red light (80 J/cm). With the concentration of MB, 50 and 150 mg/L in the third experiment (MB-aPDT), the greater bacterial reduction was observed in all clinical isolates leading to their lethal viable cell reduction when escalating the light fluence to 80 J/cm.ConclusionsMB-aPDT evidently killed the selected XDR and MDR-gram negative bacteria. In highly drug-resistant crisis era, MB-aPDT could be a promising option, particularly for local infections and infection complicating chronic wounds.
Atrial Cardiomyopathy Predicts Worse Outcome in Patients With Lung Cancer
Authors: Ren Mengdi , Ma Yuyan , Wei Meng , Ning Yuye , Liu Hui , Shi Xue , Yao Yu , Guo Fengwei 
Published: July 2022

BackgroundReports of the clinical outcomes associated with the co-occurrence of atrial cardiomyopathy (ACM) and lung cancer (LC) are limited.ObjectivesThis study aims to investigate the influence of ACM on the prognosis of LC patients and related clinical determinants.MethodsNewly diagnosed LC patients from January 1st, 2015, to December 31st, 2020, were retrospectively enrolled at the First Affiliated Hospital of Xi’an Jiaotong University. The demographics and overall survival (OS) of the patients with or without ACM were compared. The survival rate was analyzed using the Kaplan–Meier method and multivariate Cox regression analysis. Binary logistic regression analysis was used to determine the risk factors for ACM.ResultsA total of 306 patients (65.04 ± 10.30 years of age, 72.88% male) were analyzed. The prevalence of ACM in the non-small cell lung cancer (241, 78.76%) and small cell lung cancer (65, 21.24%) population was not statistically different. Overall, 53 (17.32%) LC patients had coexisting ACM. ACM patients were older (69 vs. 64, p = 0.0013) and had higher D-dimer levels (1.0 vs. 0.6, p = 0.001), lower serum calcium levels (2.23 vs. 2.31, p = 0.001), lower left ventricular ejection fraction (LVEF) values (67% vs. 69%, p = 0.036) and had more frequent coronary comorbidity disease (16.98% vs. 8.82%, p = 0.031). The median OS for patients with or without ACM was 15 months and 25 months, respectively (p = 0.018). Coexisting ACM compared to non-ACM was associated with worse OS in patients with LC (HR = 1.543, 95% CI: 1.042–2.283, p = 0.030).ConclusionCoexisting ACM is associated with undesirable survival outcomes in patients with LC. These findings could help us to better understand the cardiac burden in these patients and provide additional risk stratification for them.
The Main Builders of Mediterranean Coralligenous: 2D and 3D Quantitative Approaches for its Identification
Authors: Bracchi Valentina Alice , Bazzicalupo Pietro , Fallati Luca , Varzi Andrea Giulia , Savini Alessandra , Negri Mauro Pietro , Rosso Antonietta , Sanfilippo Rossana , Guido Adriano , Bertolino Marco , Costa Gabriele , De Ponti Elena , Leonardi Riccardo , Muzzupappa Maurizio , Basso Daniela 
Published: July 2022

Along the Mediterranean Sea shelf, algal reefs made of crustose coralline algae and Peyssonneliales are known as Coralligenous. It ranks among the most important ecosystems in the Mediterranean Sea because of its extent, complexity, and heterogeneity, supporting very high levels of biodiversity. Descriptive approaches for monitoring purposes are often aimed at assessing the surficial ephemeral canopy, which is sustained and controlled by the occurrence of the long-lasting rigid structure at the base. This practice led to the non-univocal definition of Coralligenous, sometimes indicated as “animal Coralligenous” because of the surficial dominance of these components. The quantitative assessment of the builders that actively build up the persistent structure through geological time is therefore a fundamental topic. We collected two discrete coralligenous samples in front of Marzamemi village (Sicily, Ionian Sea), the first from an area of a dense coralligenous cover (- 37 m) and the second one from an area with sparse build-ups (- 36 m). By using image analysis and computerized axial tomography, we distinguished and quantified the different components both on the surface and inside the framework. In both cases, our results confirm the primary role of crustose coralline algae as major builders of the Mediterranean Coralligenous, this aspect matching with the evidence from the Quaternary fossil record. We suggest that the role of encrusting calcareous red algae in the Coralligenous should be considered in conservation and management policies.
Sex Discrepancy Observed for Gestational Metabolic Syndrome Parameters and Polygenic Risk Associated With Preschoolers’ BMI Growth Trajectory: The Ma’anshan Birth Cohort Study
Authors: Zhu Bei-bei , Gao Hui , Geng Meng-long , Wu Xiulong , Tong Juan , Deng Fen , Zhang Si-ying , Wu Li-hong , Huang Kun , Wu Xiao-yan , Gan Hong , Zhu Peng , Tao Fang-biao 
Published: July 2022

BackgroundFew studies have investigated the associations of childhood growth trajectories with the prenatal metabolic risks of mothers and their interaction with children’s genetic susceptibility.ObjectiveTo investigate the effects of gestational metabolic syndrome (GMS) risks and children’s polygenic risk scores (PRSs), and their interaction effect on the BMI trajectory and obesity risk of offspring from birth to 6 years of age.MethodsA total of 2,603 mother-child pairs were recruited from the Ma’anshan birth cohort (Anhui Province of China) study. Data on maternal prepregnancy obesity, gestational weight gain (GWG), gestational diabetes mellitus (GDM), and hypertensive disorders of pregnancy (HDP) were used to evaluate maternal GMS risk. In addition, 1,482 cord blood samples were used to genotype 11 candidate single-nucleotide polymorphisms (SNPs) to calculate children’s PRSs. The latent class growth model using the longitudinal BMI-for-age z scores (BMIz) was applied to validly capture the BMIz growth trajectory.ResultsMaternal GMS status was associated with higher BMIz scores and with an increased risk of overweight/obesity. Positive relationships were revealed between PRS and the risk of overweight/obesity among girls. Additionally, maternal GMS significantly interacted with the child’s PRS on BMIz scores and the risk of overweight/obesity among girls. Hierarchical BMI trajectory graphs by different exposure groups showed consistent findings, and both boys’ and girls’ BMIz trajectories were divided into three groups. Among girls, the higher the GMS risk or PRS they had, the higher the probability of being in the high BMIz trajectory group.ConclusionsMaternal GMS status increased BMIz scores and the risk of obesity in both boys and girls and elevated the child’s BMI trajectory from birth to 6 years of age among girls. PRSs were significantly associated with children’s BMI trajectory and the risk of obesity and modified the associations between maternal GMS status and obesity biomarkers only among girls. Thus, regarding childhood obesity, steps should be taken to decrease maternal metabolic risks before and during pregnancy, and sex discrepancies should be noted to identify high-risk populations after birth to hierarchically manage them.
Rs864745 in JAZF1, an Islet Function Associated Variant, Correlates With Plasma Lipid Levels in Both Type 1 and Type 2 Diabetes Status, but Not Healthy Subjects
Authors: Dai Hao , Qian Yu , Lv Hui , Jiang Liying , Jiang Hemin , Shen Min , Chen Heng , Chen Yang , Zheng Shuai , Fu Qi , Yang Tao , Xu Kuanfeng 
Published: July 2022

ObjectiveThis study aims to reveal the association between JAZF1 rs864745 A&gt;G variant and type 2 diabetes (T2D), type 1 diabetes (T1D) risk, and their correlation with clinical features, including islet function, islet autoimmunity, and plasma lipid levels.MethodsWe included 2505 healthy controls based on oral glucose tolerance test (OGTT), 1736 unrelated T2D, and 1003 unrelated autoantibody-positive T1D individuals. Binary logistic regression was performed to evaluate the relationships between rs864745 in JAZF1 and T2D, T1D, and islet-specific autoantibody status under the additive model, while multiple linear regression was used to assess its effect on glycemic-related quantitative traits and plasma lipid levels.ResultsWe did not find any association between rs864745 in JAZF1 and T2D, T1D, or their subgroups (All P &gt; 0.05). For glycemic traits, we found that the G allele of this variant was significantly associated with higher 120 min insulin level, insulinogenic index (IGI), corrected insulin response (CIR), and acute insulin response (BIGTT-AIR) (P = 0.033, 0.006, 0.009, and 0.016, respectively) in healthy individuals. Similar associations were observed in newly diagnosed T2D but not T1D individuals. Although this variant had no impact on islet autoimmunity (All P &gt; 0.05), significant associations with plasma total cholesterol (TC) and low-density lipoprotein (LDL) level stratified by JAZF1 rs864745 variant were observed in the disease status of T2D (P = 0.002 and 0.003) and T1D (P = 0.024 and 0.009), with significant heterogeneity to healthy individuals.ConclusionsThe common JAZF1 rs864745 variant contributes to islet function and lipid metabolism, which might be put into genetic risk scores to assess the risk of related clinical features.