bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative proteomic analyses of Tartary buckwheat (Fagopyrum tataricum) seeds at three stages of development
Authors: Deng Jiao , Zhao Jiali , Huang Juan , Damaris Rebecca Njeri , Li Hongyou , Shi Taoxiong , Zhu Liwei , Cai Fang , Zhang Xiaona , Chen Qingfu 
Published: November 2022

Abstract
Tartary buckwheat is among the valuable crops, utilized as both food and Chinese herbal medicine. To uncover the accumulation dynamics of the main nutrients and their regulatory mechanism of Tartary buckwheat seeds, microscopic observations and nutrient analysis were conducted which suggested that starch, proteins as well as flavonoid gradually accumulated among seed development. Comparative proteomic analysis of rice Tartary buckwheat at three different developmental stages was performed. A total of 78 protein spots showed differential expression with 74 of them being successfully identified by MALDI-TOF/TOF MS. Among them, granule bound starch synthase (GBSS1) might be the critical enzyme that determines starch biosynthesis, while 11 S seed storage protein and vicilin seemed to be the main globulin and affect seed storage protein accumulation in Tartary buckwheat seeds. Two enzymes, flavanone 3-hydroxylase (F3H) and anthocyanidin reductase (ANR), involved in the flavonoid biosynthesis pathway were identified. Further analysis on the expression profiles of flavonoid biosynthetic genes revealed that F3H might be the key enzyme that promote flavonoid accumulation. This study provides insights into the mechanism of nutrition accumulation at the protein level in Tartary buckwheat seeds and may facilitate in the breeding and enhancement of Tartary buckwheat germplasm.
The value of comorbidities and illness severity scores as prognostic tools for early outcome estimation in patients with aneurysmal subarachnoid hemorrhage
Authors: Malinova Vesna , Sheri Tuzi , Kranawetter Beate , Moerer Onnen , Rohde Veit , Mielke Dorothee 
Published: November 2022

AbstractAneurysmal subarachnoid hemorrhage (aSAH) is a severe cerebrovascular disease not only causing brain injury but also frequently inducing a significant systemic reaction affecting multiple organ systems. In addition to hemorrhage severity, comorbidities and acute extracerebral organ dysfunction may impact the prognosis after aSAH as well. The study objective was to assess the value of illness severity scores for early outcome estimation after aSAH. A retrospective analysis of consecutive aSAH patients treated from 2012 to 2020 was performed. Comorbidities were evaluated applying the Charlson comorbidity index (CCI) and the American Society of Anesthesiologists (ASA) classification. Organ dysfunction was assessed by calculating the simplified acute physiology score (SAPS II) 24 h after admission. Modified Rankin scale (mRS) at 3 months was documented. The outcome discrimination power was evaluated. A total of 315 patients were analyzed. Significant comorbidities (CCI > 3) and physical performance impairment (ASA > 3) were found in 15% and 12% of all patients, respectively. The best outcome discrimination power showed SAPS II (AUC 0.76), whereas ASA (AUC 0.65) and CCI (AUC 0.64) exhibited lower discrimination power. A SAPS II cutoff of 40 could reliably discriminate patients with good (mRS ≤ 3) from those with poor outcome (p < 0.0001). Calculation of SAPS II allowed a comprehensive depiction of acute organ dysfunctions and facilitated a reliable early prognosis estimation in our study. In direct comparison to CCI and ASA, SAPS II demonstrated the highest discrimination power and deserves a consideration as a prognostic tool after aSAH.
Asymptotic properties and convolutions of some almost periodic functions with applications
Authors: Bugajewski Dariusz , Kasprzak Kosma , Nawrocki Adam 
Published: November 2022

AbstractIn this note we are going to continue investigation concerning the asymptotic behavior of some Levitan almost periodic functions or almost periodic functions in view of the Lebesgue measure as well as their convolutions with some functions naturally arising in the theory of ordinary linear differential equations. In particular, we obtain some estimations for functions (1), where $$\alpha$$
α
is an irrational number of finite irrationality measure or a Liouville number. We also focus on the set of all irrational numbers for which the convolution of function (1) with function (2) exists. In particular, we characterize it from the topological and set-theoretical point of view.
Speckle-tracking echocardiography for predicting improvement of myocardial contractile function after revascularization: a meta-analysis of prospective trials
Authors: Ballo Haitham , Doghman Fatma , Hartikainen Juha , Saraste Antti , Knuuti Juhani 
Published: November 2022

AbstractSome studies have indicated that the use of 2D-Speckle tracking echocardiography (2DSTE) aids in predicting recovery of myocardial contractile function after revascularization in patients with chronic ischemic left ventricular (LV) dysfunction or acute myocardial infarction (MI). The purpose of this meta-analysis was to evaluate the diagnostic accuracy of 2DSTE strain in the detection of myocardial viability at rest and during low-dose dobutamine (LDD) stress. A systematic review for all prospective trials using 2DSTE to assess myocardial viability until January 2019 was done. Using a standard approach of meta-analysis for diagnostic tests. Overall, nine studies including 525 patients with either chronic ischemic heart disease or acute MI fulfilled the inclusion criteria. Seven studies used longitudinal strain (LS) at rest, nine studies used circumferential strain (CS) at rest, four studies used LS during LDD stress, and four studies used CS during LDD stress. LS and CS during LDD stress showed equally high sensitivity (81.5% and 81.5% respectively) and specificity (81.3% and 81.4% respectively) for detecting reversible dysfunction. At rest, LS and CS showed equally lower sensitivity (67.1%, p < 0.0001 vs. LDD stress and 68.7%, p < 0.0001, vs. LDD stress, respectively) and specificity (64%, p < 0.0001 vs. LDD stress and 65.7%, p = 0.0008 vs. LDD stress, respectively) as compared with LDD stress. LS and CS by 2DSTE during LDD stress accurately identify reversible ischemic myocardial dysfunction in patients with chronic ischemic LV dysfunction or after MI. The use of LDD stress can be recommended over resting strain measures in this setting.
Biodegradable PEG-PCL Nanoparticles for Co-delivery of MUC1 Inhibitor and Doxorubicin for the Confinement of Triple-Negative Breast Cancer
Authors: Behl Akanksha , Solanki Subhash , Paswan Shravan K. , Datta Tirtha K. , Saini Adesh K. , Saini Reena V. , Parmar Virinder S. , Thakur Vijay Kumar , Malhotra Shashwat , Chhillar Anil K. 
Published: November 2022

AbstractCombating triple-negative breast cancer (TNBC) is still a problem, despite the development of numerous drug delivery approaches. Mucin1 (MUC1), a glycoprotein linked to chemo-resistance and progressive malignancy, is unregulated in TNBC. GO-201, a MUC1 peptide inhibitor that impairs MUC1 activity, promotes necrotic cell death by binding to the MUC1-C unit. The current study deals with the synthesis and development of a novel nano-formulation (DM-PEG-PCL NPs) comprising of polyethylene glycol-polycaprolactone (PEG-PCL) polymer loaded with MUC1 inhibitor and an effective anticancer drug, doxorubicin (DOX). The DOX and MUC1 loaded nanoparticles were fully characterized, and their different physicochemical properties, viz. size, shape, surface charge, entrapment efficiencies, release behavior, etc., were determined. With IC50 values of 5.8 and 2.4 nm on breast cancer cell lines, accordingly, and a combination index (CI) of < 1.0, DM-PEG-PCL NPs displayed enhanced toxicity towards breast cancer cells (MCF-7 and MDA-MB-231) than DOX-PEG-PCL and MUC1i-PEG-PCL nanoparticles. Fluorescence microscopy analysis revealed DOX localization in the nucleus and MUC1 inhibitor in the mitochondria.Further, DM-PEG-PCL NPs treated breast cancer cells showed increased mitochondrial damage with enhancement in caspase-3 expression and reduction in Bcl-2 expression.In vivo evaluation using Ehrlich Ascites Carcinoma bearing mice explicitly stated that DM-PEG-PCL NPs therapy minimized tumor growth relative to control treatment. Further, acute toxicity studies did not reveal any adverse effects on organs and their functions, as no mortalities were observed.The current research reports for the first time the synergistic approach of combination entrapment of a clinical chemotherapeutic (DOX) and an anticancer peptide (MUC1 inhibitor) encased in a diblock PEG-PCL copolymer. Incorporating both DOX and MUC1 inhibitors in PEG-PCL NPs in the designed nanoformulation has provided chances and insights for treating triple-negative breast tumors. Our controlled delivery technology is biodegradable, non-toxic, and anti-multidrug-resistant. In addition, this tailored smart nanoformulation has been particularly effective in the therapy of triple-negative breast cancer.
Influence of drying technique on Pt/In2O3 aerogels for methanol steam reforming
Authors: Thoni Lukas , Metzkow Nadia , Eychmüller Alexander 
Published: November 2022

AbstractIn this paper we present a comparison of aerogels which are dried under different conditions. Of those, most important are the solvent, temperature, and pressure. Criteria of comparison rely mostly on results from analysis of nitrogen adsorption experiments, as well as transmission electron microscopy imaging. Platinum loaded indium oxide aerogels were picked as a model system for this study as they can be used as highly effective heterogeneous catalysts in methanol steam reforming. The compared drying methods include supercritical drying from CO2, supercritical CO2 - ethanol mixture, freeze drying from tert-butanol and ambient conditions drying from acetone and 1-Methoxyheptafluoropropane. High porosities and large specific surface areas can be achieved via supercritical, freeze- and ambient conditions drying, while retaining the original gel morphology in this system for most methods except freeze drying and ambient conditions drying from acetone.
The Effects of Medical Male Circumcision on Female Partners’ Sexual and Reproductive Health
Authors: Mehta Supriya D. 
Published: November 2022

Abstract
Purpose of Review
Voluntary medical male circumcision (VMMC) reduces the risk of HIV acquisition by 60% among heterosexual men, provides protection against certain sexually transmitted infections (STI), and leads to penile microbiome composition changes associated with reduced risk of HIV infection. Intuitively, the benefits of VMMC for female sex partners in relation to STI are likely and have been evaluated. The purpose of this review is to examine emerging findings of broader sexual and reproductive health (SRH) benefits of VMMC for female sex partners.

Recent Findings
Systematic reviews find strong evidence for beneficial effects of VMMC on female sex partners risk of HPV, cervical dysplasia, cervical cancer, and with likely protection against trichomoniasis and certain genital ulcerative infections. Few studies assess the direct impact of VMMC on the vaginal microbiome (VMB), though several studies demonstrate reductions in BV, which is mediated by the VMB. Studies are lacking regarding male circumcision status and outcomes associated with non-optimal VMB, such as female infertility and adverse pregnancy outcomes. VMMC has positive effects on women’s perceptions of sexual function and satisfaction, and perceptions of disease risk and hygiene, without evidence of risk compensation.

Summary
VMMC has consistent association with a broad range of women’s SRH outcomes, highlighting the biological and non-biological interdependencies within sexual relationships, and need for couples-level approaches to optimize SRH for men and women. The paucity of information on VMMC and influence on VMB is a barrier to optimizing VMB-associated SRH outcomes in female partners.
Defining the Global Research and Programmatic Agenda and Priority Actions for Voluntary Medical Male Circumcision for HIV Prevention
Authors: Peck Megan E. , Lucas Todd , Ong Katherine S. , Grund Jonathan M. , Davis Stephanie , Yansaneh Aisha , Kiggundu Valerian L. , Thomas Anne G. , Curran Kelly , Laube Catharine , Sundaram Maaya , Ameyan Wole , Zembe Lycias , Toledo Carlos 
Published: November 2022

AbstractPurpose of ReviewSince 2007, voluntary medical male circumcision (VMMC) programs have been associated with substantially reduced HIV incidence across 15 prioritized countries in Eastern and Southern Africa. Drawing on the programmatic experience of global VMMC leaders, this report reviews progress made in the first 15 years of the program, describes programmatic and research gaps, and presents considerations to maximize the impact of VMMC.Recent FindingsOverall, key programmatic and research gaps include a lack of robust male circumcision coverage estimates due to limitations to the data and a lack of standardized approaches across programs; challenges enhancing VMMC uptake include difficulties reaching populations at higher risk for HIV infection and men 30 years and older; limitations to program and procedural quality and safety including variations in approaches used by programs; and lastly, sustainability with limited evidence-based practices. Considerations to address these gaps include the need for global guidance on estimating coverage, conducting additional research on specific sub-populations to improve VMMC uptake, implementation of responsive and comprehensive approaches to adverse event surveillance, and diversifying financing streams to progress towards sustainability.SummaryThis report’s findings may help establish a global VMMC research and programmatic agenda to inform policy, research, and capacity-building activities at the national and global levels.
Insomnia symptoms do, but chronotype does not show relevant associations with mental well-being and negative dream experiences
Authors: Benkő Zsófia , Köteles Ferenc , Simor Péter 
Published: November 2022

Abstract
Chronotypes are diversely associated with sleep quality and mental health. Eveningness is generally associated with lower sleep quality and with increased risk for mental health complaints. Along with insomnia symptoms, frequent dysphoric dreams might be key elements of disturbed sleep, and may also indicate psychological imbalance. Our cross-sectional online study aimed to examine whether eveningness can be considered as an independent risk factor of poor mental well-being or whether this association is explained by symptoms of insomnia. Secondly, we examined the associations between eveningness and frequent dysphoric dreaming taking into account the influence of mental well-being and insomnia complaints. Method: We released an online survey with Morningness-Eveningness Questionnaire, Athens Insomnia Scale, General Mental Health, and frequency of dysphoric dreaming: nightmares and bad dreams separately. We analyzed the data of 2077 participants (MAGE = 28.5, SD = 9.6). Eveningness showed a weak but independent association with mental well-being. Additional analyses showed no signs of associations between eveningness and dysphoric dreaming, such as nightmares and bad dreams. The frequency of bad dreams was associated with insomnia complaints and mental well-being, but nightmare frequency was only linked to insomnia symptoms, but not to mental well-being. Insomnia complaints emerged as a more robust factor in poorer mental well-being than the eveningness preference. Eveningness was not associated with dysphoric dreaming. Restoring insomnia might be essential in individuals at risk for mental health complaints.
Environmental sensitivity increases susceptibility to resilient contexts in adults with childhood experiences of neglect
Authors: Di Paola Ludovica , Nocentini Annalaura , Lionetti Francesca 
Published: November 2022

AbstractEmpirical evidence regarding the impact of childhood emotional neglect on later adjustment is mixed, with some studies reporting neglect to predict low psychological well-being, while others reporting a well-adjusted development despite childhood experiences of emotional neglect. This heterogeneity is understood within a resilient framework where individual and contextual factors act as moderators. This is the first study investigating the moderating role of environmental sensitivity and contextual resilience on the association between childhood emotional neglect and psychological well-being.737 students from the University of Florence with an age ranging from 18 to 30 years (M = 19.81; SD = 1.91; 87% female) took part in the research. To investigate the effects of childhood emotional neglect on relational well-being, and the moderating role of environmental sensitivity and contextual resilience on the impact of emotional neglect, a series of generalized linear models, including only main effects and then adding interaction terms, were run and compared. Results provided support for a three-way interaction model, with environmental sensitivity and contextual resilience moderating the impact of childhood emotional neglect on relational well-being in young adulthood (B = .37, SE = .11, p < .001). Among those who experienced severe levels of childhood emotional neglect, young adults high in environmental sensitivity were more susceptible to the positive impact of supportive contexts, presenting higher levels of well-being compared to those low in environmental sensitivity. This study suggests that promoting supportive contexts in adulthood might reduce the impact of severe childhood emotional neglect, particularly in individuals with an increased environmental sensitivity.
Determination of Optimum Zn Content for Mg–xZn–0.5Mn–0.5Sr Alloy in Terms of Mechanical Properties and In Vitro Corrosion Resistance
Authors: Suh Joung Sik , Ha Heon-Young , Suh Byeong-Chan , Kang Jae-Wook 
Published: November 2022

Abstract
This study investigated the microstructure, compressive properties and in vitro corrosion behavior of biodegradable Mg–xZn–0.5Mn–0.5Sr (ZMJ) alloy with Zn content of 0 to 5 wt% in the as-cast state. Increasing the Zn content in ZMJ alloy refined the grains from 215 to 95 µm and changed the secondary particles from Mg17Sr2 to Mg6Zn2Sr and MgZn phases. As the Zn content increased, the compressive yield strength increased from 44 to 67 MPa due to grain boundary strengthening. At immersion in phosphate-buffered saline for 7 days, the addition of Zn from 0 to 0.1 wt% reduced the corrosion rate from 0.71 to 0.48 mm/y, and 0.85 wt% Zn was alloyed to obtain the lowest corrosion rate of 0.45 mm/y. However, adding more Zn significantly increased the corrosion rate up to 3.31 mm/y. Thus, the best anti-corrosion performance can be obtained at 0.85 wt% Zn, which was attributed to its lowest Volta potential difference between the main secondary particles and the α-Mg matrix among ZMJ alloy. Based on this, the optimal Zn content for ZMJ alloy can be determined to be about 1 wt% by comprehensively considering the mechanical properties and in vitro corrosion behavior for biomedical applications.

Graphical abstract
Micrographs of (a,c) the specimen as-built in vertical direction (Type I) and (b,d) the specimen as-built in horizontal direction (Type II) to the building platform.
Is government funding critical to the operating performance of technology universities? A case study of Taiwan
Authors: He Dong-Sing , Tebourbi Imen 
Published: November 2022

AbstractThis study utilizes the Malmquist Productivity Index (MPI) to evaluate the operating performance of technology universities in Taiwan. The bootstrap method is employed to analyze MPI sensitivity to verify the index’s stability. Our results suggest that the universities demonstrate an adequate level of performance with little improvement required. Technology universities with a greater proportion of total income from government subsidies did not evidence better operating performance. We argue that how universities obtain their funding is critical. Our findings will help universities (and their relevant departments) improve performance and better allocate resources.
Overcoming the Technical Challenges of Total Knee Arthroplasty in Patients Affected by Hereditary Multiple Exostoses: a Case Report and Literature Review
Authors: Cammisa Eugenio , Alesi Domenico , Meena Amit , Lullini Giada , Zaffagnini Stefano , Marcheggiani Muccioli Giulio Maria 
Published: November 2022

Abstract

Hereditary multiple exostoses (HME), also known as familiar osteochondromatosis or diaphyseal aclasis, are an autosomal dominant inherited genetic pathology that is characterized by the presence of multiple benign osteochondromas. Knee deformity is common in patients with HME, with nearly a third of patients developing genu valgus. Total knee arthroplasty (TKA) has been used to correct valgus deformities with advanced knee osteoarthritis (OA). However, concomitant limb deformities and altered anatomy of the knee make this surgery particularly challenging. We present a case report and a mini-review of the literature on this topic. We present the case of a 50-year-old Caucasian woman, affected by hereditary multiple exostoses, who came to our attention for progressive pain in the right knee. Upon further examination, the knee had a prominent valgus alignment, concomitant valgus instability, and flexion contraction. The patient was treated with total knee arthroplasty using a semi-constrained design. The patient was re-evaluated at 24-month follow-up, and there were no signs of implant loosening, the knee function improved significantly, and the patient was very satisfied. Given the recurring technical difficulties of such procedure in these patients, we describe our experience as well as the need for preoperative planning, the use of appropriate constraint when required, the high frequency of ligament instability, bony defects, and patellar maltracking. TKA must be considered when necessary, in these patients, as good to excellent clinical results can be achieved and maintained, allowing for significant improvements in quality of life.

Core Tips

- TKA in HME-affected patients carries specific but manageable challenges.
- Due to bone deformities and frequent severe valgus knee alignment, TKA should be considered even in younger patients.
- Revision implants provide the flexibility and the necessary fixation, not always achievable with primary implants.
- Bigger size components may be necessary in HME patients compared with patients of the same height.
- Lateral ligament releases may often be necessary due to long-standing valgus deformity. If stability cannot be achieved, the use of a hinged implant should be considered.
- Cementation of the metaphysis or the use of sleeves can provide additional rotational stability to the implant.
Statistical mechanics in climate emulation: Challenges and perspectives
Authors: Sudakow Ivan , Pokojovy Michael , Lyakhov Dmitry 
Published: November 2022

AbstractClimate emulators are a powerful instrument for climate modeling, especially in terms of reducing the computational load for simulating spatiotemporal processes associated with climate systems. The most important type of emulators are statistical emulators trained on the output of an ensemble of simulations from various climate models. However, such emulators oftentimes fail to capture the “physics” of a system that can be detrimental for unveiling critical processes that lead to climate tipping points. Historically, statistical mechanics emerged as a tool to resolve the constraints on physics using statistics. We discuss how climate emulators rooted in statistical mechanics and machine learning can give rise to new climate models that are more reliable and require less observational and computational resources. Our goal is to stimulate discussion on how statistical climate emulators can further be improved with the help of statistical mechanics which, in turn, may reignite the interest of statistical community in statistical mechanics of complex systems.