bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a framework for culture-based interventions for well-being in Cluj-Napoca, Romania
Authors: Cacovean Claudia-Maria , Dascăl Marina-Denisa , Zbranca Maria-Rarița 
Published: December 2022

AbstractThe article discusses the context and conditions for implementing culture-based interventions for health and well-being in an urban setting. Specifically, the article presents the case study of a cultural intervention aimed at reducing burnout-related symptoms in adults, describing the context of the intervention, the project design, implementation, and the impact assessment. Following the assessment of the implementation, the next steps in order to scale up the piloted intervention for other people confronting burnout have been identified. Further on, the article analyses the factors that future policies and programmes should take into account for enabling local communities to draw most benefits from the contribution of arts and culture for health and well-being, by proposing possible avenues for scaling up the pilot initiative.
Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model
Authors: Jeong Hwain , Park Inwon , Lee Jae Hyuk , Kim Dongsung , Baek Sumin , Kim Seonghye , Jo You Hwan 
Published: December 2022

AbstractFluid resuscitation is crucial in the initial management of sepsis; however, little is known about the serial changes and overall distribution of fluids administered into the body. To identify the feasibility of longitudinal bioelectrical impedance analysis during fluid treatment, a preclinical porcine model of Escherichia coli-induced sepsis was used. After sepsis induction, pigs were treated with fluid and vasopressors and monitored for up to 12 h after bacterial infusion or until death. Bipolar electrodes for bioelectrical impedance analysis were attached to the left extremities and measurements were performed every 10 min. Among the 12 subjects, 7 pigs expired during the experiment, and the median survival was 9.5 h. As sepsis progressed with an increase in cumulative fluid balance, R0 [∝ 1/extracellular water (ECW)] decreased, while Ri [∝ 1/intracellular water (ICW)] and ratio of extracellular water to total body water (ECW/TBW) increased. The phase angle constantly decreased throughout the monitoring period, and all non-survivors died when the phase angle decreased by more than 10%. Among the variables, ΔR0 and Δphase angle showed moderate negative correlations, and ΔECW/TBW showed a moderate positive correlation with the hourly fluid balance. Compared to survivors, a greater increase in ΔECW/TBW and a decrease in phase angle were observed in non-survivors over time, with an increase in cumulative fluid balance. Differences in ΔECW/TBW and phase angle emerged at 240 min when the difference in cumulative fluid balance between the two groups (survivors vs non-survivors) exceeded 1000 mL. In conclusion, continuous measurements of bioelectrical impedance analysis in a porcine sepsis model are feasible and may reflect changes in the body water profile during fluid resuscitation.
Machine learning identifies prominent factors associated with cardiovascular disease: findings from two million adults in the Kashgar Prospective Cohort Study (KPCS)
Authors: Li Jia-Xin , Li Li , Zhong Xuemei , Fan Shu-Jun , Cen Tao , Wang Jianquan , He Chuanjiang , Zhang Zhoubin , Luo Ya-Na , Liu Xiao-Xuan , Hu Li-Xin , Zhang Yi-Dan , Qiu Hui-Ling , Dong Guang-Hui , Zou Xiao-Guang , Yang Bo-Yi 
Published: December 2022

Abstract
Background
Identifying factors associated with cardiovascular disease (CVD) is critical for its prevention, but this topic is scarcely investigated in Kashgar prefecture, Xinjiang, northwestern China. We thus explored the CVD epidemiology and identified prominent factors associated with CVD in this region.

Methods
A total of 1,887,710 adults at baseline (in 2017) of the Kashgar Prospective Cohort Study were included in the analysis. Sixteen candidate factors, including seven demographic factors, 4 lifestyle factors, and 5 clinical factors, were collected from a questionnaire and health examination records. CVD was defined according to International Clinical Diagnosis (ICD-10) codes. We first used logistic regression models to investigate the association between each of the candidate factors and CVD. Then, we employed 3 machine learning methods—Random Forest, Random Ferns, and Extreme Gradient Boosting—to rank and identify prominent factors associated with CVD. Stratification analyses by sex, ethnicity, education level, economic status, and residential setting were also performed to test the consistency of the ranking.

Results
The prevalence of CVD in Kashgar prefecture was 8.1%. All the 16 candidate factors were confirmed to be significantly associated with CVD (odds ratios ranged from 1.03 to 2.99, all p values < 0.05) in logistic regression models. Further machine learning-based analysis suggested that age, occupation, hypertension, exercise frequency, and dietary pattern were the five most prominent factors associated with CVD. The ranking of relative importance for prominent factors in stratification analyses showed that the factor importance generally followed the same pattern as that in the overall sample.

Conclusions
CVD is a major public health concern in Kashgar prefecture. Age, occupation, hypertension, exercise frequency, and dietary pattern might be the prominent factors associated with CVD in this region.In the future, these factors should be given priority in preventing CVD in future.
Trichoblastomas derived from the facial skin with tactile hair in aged house musk shrews (Suncus murinus)
Authors: Kimura Tohru 
Published: December 2022

Abstract
Background
Benign hair follicle tumors are relatively rare cutaneous neoplasms arising from hair follicle differentiation. These tumors are slow-growing solitary papules or nodules in the head, face or neck. The aim of this study was to describe 2 cases of trichoblastomas in tactile hair skin incidentally encountered in aged house musk shrews (Suncus murinus). In addition, this case report clarifies whether the characteristics in the tactile hair skin of Suncus murinus are different from those in humans and other animals.

Case presentation
The animals were investigated the characteristics of the clinical findings, hematological and serum biochemical profiles (particularly, serum amyloid A levels (vSAA)), and histopathological results. Suncus murinus with the facial tumor showed weight loss and coarse fur. Hematological examinations indicated microcytic and normochromic anemia. Although few apparent changes were serum biochemically found in Suncus murinus, vSAA levels moderately increased and revealed inflammatory reactions. These lesions histopathologically showed the basaloid islands comprising peripheral palisading and dilated microcysts containing variable admixtures of free-floating cells such as neoplasm cells, giant cells, clear cells, mononuclear cells and erythrocytes.

Conclusions
The author concluded that trichoblastomas in Suncus murinus revealed growth and morphological characteristics that recapitulate part of embryological development in the tactile hair follicles. In the histological structure, their trichoblastomas in the tactile hair skin were different from those found in humans and animals such as cats, dogs and other wildlife.
Ischial screw fixation can prevent cup migration in 3D-printed custom acetabular components for complex hip reconstruction
Authors: Madanipour Suroosh , Lemanu Daniel , Jayadev Chethan , Aston Will , Donaldson James , Miles Jonathan , Carrington Richard , McCulloch Robert , Skinner John 
Published: December 2022

Abstract
Introduction
Custom acetabular components have become an established method of treating massive acetabular bone defects in hip arthroplasty. Complication rates, however, remain high and migration of the cup is still reported. Ischial screw fixation (IF) has been demonstrated to improve mechanical stability for non-custom, revision arthroplasty cup fixation. We hypothesize that ischial fixation through the flange of a custom acetabular component aids in anti-rotational stability and prevention of cup migration.

Methods
Electronic patient records were used to identify a consecutive series of 49 custom implants in 46 patients from 2016 to 2022 in a unit specializing in complex joint reconstruction. IF was defined as a minimum of one screw inserted into the ischium passing through a hole in a flange on the custom cup.
The mean follow-up time was 30 months. IF was used in 36 cups. There was no IF in 13 cups. No difference was found between groups in age (68.9 vs. 66.3, P = 0.48), BMI (32.3 vs. 28.2, P = 0.11) or number of consecutively implanted cups (3.2 vs. 3.6, P = 0.43). Aseptic loosening with massive bone loss was the primary indication for revision. There existed no difference in Paprosky grade between the groups (P = 0.1). 14.2% of hips underwent revision and 22.4% had at least one dislocation event.

Results
No ischial fixation was associated with a higher risk of cup migration (6/13 vs. 2/36, X2 = 11.5, P = 0.0007). Cup migration was associated with an increased risk for all cause revision (4/8 vs. 3/38, X2 = 9.96, P = 0.0016, but not with dislocation (3/8 vs. 8/41, X2 = 1.2, P = 0.26).

Conclusion
The results suggest that failure to achieve adequate ischial fixation, with screws passing through the flange of the custom component into the ischium, increases the risk of cup migration, which, in turn, is a risk factor for revision.
Extended drug-resistant Salmonella typhi osteomyelitis: a case report and literature review
Authors: Irshad Memoona , Mahmood Syed Faisal 
Published: December 2022

Abstract
Background
Salmonella typhi infection commonly results in gastroenteritis, bacteremia with or without secondary seeding, or asymptomatic carrier stage. Few cases of Salmonella typhi bacteremia later result in seeding and ultimately lead to further complications including osteomyelitis and rarely vertebral osteomyelitis.

Case presentation
We are discussing a case of a 38-year-old Asian male patient, with no known comorbids. He presented with fever and backache for 4 weeks. Based on the magnetic resonance imaging (MRI) findings of the spine and positive blood cultures, a diagnosis of XDR Salmonella typhi (S. typhi) osteomyelitis (OM) was made. Patient was started on intravenous therapy as per culture report which was later modified according to treatment response.

Conclusion
S. typhi has a broad spectrum of clinical manifestations including osteomyelitis however to the best of our knowledge this is the first reported case of XDR S. typhi vertebral osteomyelitis. We describe the clinical course of the patient and review the literature regarding the treatment of S.typhi vertebral osteomyelitis with a special focus on XDR S. typhi. Treatment course and complications in view of this new resistant strain have to be reported in order to devise general guidelines for the management in such particular cases.
Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651
Authors: Haddad Robert I. , Harrington Kevin , Tahara Makoto , Ferris Robert L. , Gillison Maura , Fayette Jerome , Daste Amaury , Koralewski Piotr , Zurawski Bogdan , Taberna Miren , Saba Nabil F. , Mak Milena , Kawecki Andrzej , Girotto Gustavo , Alvarez Avitia Miguel Angel , Even Caroline , Toledo Joaquin Gabriel Reinoso , Guminski Alexander , Müller-Richter Urs , Kiyota Naomi , Roberts Mustimbo , Khan Tariq Aziz , Miller-Moslin Karen , Wei Li , Argiris Athanassios 
Published: December 2022

PURPOSE CheckMate 651 (ClinicalTrials.gov identifier: NCT02741570 ) evaluated first-line nivolumab plus ipilimumab versus EXTREME (cetuximab plus cisplatin/carboplatin plus fluorouracil ≤ six cycles, then cetuximab maintenance) in recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). METHODS Patients without prior systemic therapy for R/M SCCHN were randomly assigned 1:1 to nivolumab plus ipilimumab or EXTREME. Primary end points were overall survival (OS) in the all randomly assigned and programmed death-ligand 1 combined positive score (CPS) ≥ 20 populations. Secondary end points included OS in the programmed death-ligand 1 CPS ≥ 1 population, and progression-free survival, objective response rate, and duration of response in the all randomly assigned and CPS ≥ 20 populations. RESULTS Among 947 patients randomly assigned, 38.3% had CPS ≥ 20. There were no statistically significant differences in OS with nivolumab plus ipilimumab versus EXTREME in the all randomly assigned (median: 13.9 v 13.5 months; hazard ratio [HR], 0.95; 97.9% CI, 0.80 to 1.13; P = .4951) and CPS ≥ 20 (median: 17.6 v 14.6 months; HR, 0.78; 97.51% CI, 0.59 to 1.03; P = .0469) populations. In patients with CPS ≥ 1, the median OS was 15.7 versus 13.2 months (HR, 0.82; 95% CI, 0.69 to 0.97). Among patients with CPS ≥ 20, the median progression-free survival was 5.4 months (nivolumab plus ipilimumab) versus 7.0 months (EXTREME), objective response rate was 34.1% versus 36.0%, and median duration of response was 32.6 versus 7.0 months. Grade 3/4 treatment-related adverse events occurred in 28.2% of patients treated with nivolumab plus ipilimumab versus 70.7% treated with EXTREME. CONCLUSION CheckMate 651 did not meet its primary end points of OS in the all randomly assigned or CPS ≥ 20 populations. Nivolumab plus ipilimumab showed a favorable safety profile compared with EXTREME. There continues to be a need for new therapies in patients with R/M SCCHN.
Cross-Sectional Analysis of Clinical Trial Availability and North Carolina Neighborhood Social Vulnerability
Authors: Grant Shakira J. , Jansen Matthew , Kuo Tzy-Mey , Rubinstein Samuel M. , Wildes Tanya M. , Tuchman Sascha A. , Muss Hyman B. , Lichtman Eben I. , Charlot Marjory 
Published: December 2022

PURPOSE:Residents of communities facing social vulnerability (eg, poverty) have limited access to clinical trials, leaving them susceptible to experiencing poor health outcomes. We examined the association between North Carolina county-level social vulnerability and available multiple myeloma (MM) trials.METHODS:Using a novel data linkage between ClinicalTrials.gov, the 2019 American Community Survey, and the Centers for Disease Control and Prevention's Social Vulnerability Index, we investigated at the county level (1) availability of MM trial sites and (2) the relationship between Social Vulnerability Index and MM trial site availability using logistic regression.RESULTS:Between 2002 and 2021, 229 trials were registered across 462 nonunique trial sites in 34 counties. Nearly 50% of trial sites were in academic medical centers, 80% (n = 372) of all trials were industry-sponsored, 60% (n = 274) were early-phase, and 50% (n = 232) were for patients with relapsed or refractory MM. Counties with low as opposed to high poverty rates had six times greater odds of having ≥ 1 MM trial sites (odds ratio [OR], 5.60; 95% CI, 1.85 to 19.64; P = .004). Counties with the lowest percentage of Black Indigenous Persons of Color and non-native English speakers had 77% lower odds (OR, 0.23; 95% CI, 0.07 to 0.69; P = .011) of having ≥ 1 trial sites. The effect remained significant after accounting for the presence of five academic medical centers (n = 95; OR, 0.18; 95% CI, 0.05 to 0.6; P = .008) and adjustment for metropolitan, suburban, or rural status (OR, 0.25; 95% CI, 0.07 to 0.81; P = .025).CONCLUSION:Counties with the lowest poverty rates had more MM trial sites, whereas those with the lowest percentage of Black Indigenous Persons of Color populations had fewer MM trial sites. Multilevel efforts are needed to improve the availability and access to trials for socially vulnerable populations.
Analysis of Albania's diplomatic relations with the Soviet Union during the years 1948-1959
Authors: Xhaferri Manjola , tase mirela 
Published: December 2022

Background: This paper aims to shed light on a very intense period of relations between Albania and the Soviet Union (USSR), focusing on the period from 1948 with the intensification of Albania's relations with the USSR until the termination of diplomatic relations in 1959. The main objective of this paper is to know the truth of the relations of the USSR and its behavior with Albania. Methods: The paper focuses on analyzing this period as a case study, selecting three levels (context-actors-outcomes). Evaluation of the period (1948-1959) is done through the identification of key indicators and the implications of the relationship in domestic and international contexts. The sources used include documents, interviews, films, newspapers, and books. We requested permission to use the Archival resources of the Albanian Central State Archives (AQSH), where they made some accessible non-state secret resources workable only within the archive available to us. Results: The facts show that the relations between Albania and the USSR benefitted Albania more. particularly with a lot of economic support from the USSR, which helped Albania emerge from crisis and build the so-called ‘socialist state’. Through these relations and contributions, Albania took its place in the international arena. We find that this may be because of the geographical position of Albania, as the construction of the Pashaliman naval base and the bay of Vlora indicates. Conclusions: This study tries to demystify this relationship that has had a lot of ambiguity cast over it. Documents of the AQSH do not provide an unbiased overview, as they were compiled with an ideologically charged spirit, making it difficult for researchers to reach conclusions without ideological input from both sides. We hope that we will have the opportunity to access restricted documents to provide a clearer picture of the relations between Albania and the USSR.
Case Report: The first reported case of pulmonary alveolar proteinosis with myasthenia gravis in a 27-year-old patient
Authors: Ben Hmida Lenda , Mejri Islam , Kacem Maroua , Msalmani Mariem , Blibech Hana , Snène Houda , Ayadi Aida , Zaouali Jamel , Moatemri Zied 
Published: December 2022

Background: Pulmonary alveolar proteinosis is a very rare diffuse lung disease characterized by the accumulation of amorphous and periodic acid Schiff-positive lipoproteinaceous material in the alveolar spaces due to impaired surfactant clearance by alveolar macrophages. Three main types were identified: Autoimmune, secondary and congenital. Pulmonary alveolar proteinosis has been previously reported to be associated with several systemic auto-immune diseases. Accordingly, we present the first case report of pulmonary alveolar proteinosis associated with myasthenia gravis. Case: A 27-year-old female patient, ex-smoker, developed a dyspnea on exertion in 2020. The chest X-ray detected diffuse symmetric alveolar opacities. Pulmonary infection was ruled out, particularly COVID-19 infection. The chest scan revealed the “crazy paving” pattern. The bronchoalveolar lavage showed a rosy liquid with granular acellular eosinophilic material Periodic acid-Schiff positive. According to the lung biopsy results, she was diagnosed with pulmonary alveolar proteinosis. The granulocyte macrophage colony-stimulating factor autoantibodies were negative. Nine months later, she was diagnosed with bulbar seronegative myasthenia gravis, confirmed with the electroneuromyography with repetitive nerve stimulation showing significant amplitude decrement of the trapezius and spinal muscles. She was treated with pyridostigmine, oral corticosteroids and azathioprine. Given the worsening respiratory condition of the patient, a bilateral whole lung lavage was performed with a partial resolution of symptoms. Thus, this previously unreported association was treated successfully with rituximab, including improvement of dyspnea, diplopia and muscle fatigability at six months of follow-up. Conclusions: This case emphasizes on the possible association of auto-immune disease to PAP, which could worsen the disease course, as the specific treatment does not exist yet. Hence, further studies are needed to establish clear-cut guidelines for PAP management, particularly when associated to auto-immune diseases.
A rapid review of the prevalence and onset of urticaria triggered by COVID-19 vaccine
Authors: Oktarina Dyah Ayu Mira , Fadhal Irsyad , Febriana Sri Awalia , Kusuma Arditya Damar 
Published: December 2022

Background: The Coronavirus Disease 2019 (COVID-19) vaccine is essential to reduce the spread of this disease virus and is very effective at preventing patients with severe symptoms of the disease from dying. As of February 2022, more than 10 billion doses of the COVID-19 vaccine have been administered worldwide, and at least 60% of the world's population have received the first dose of the vaccine. The increasing number of populations receiving the COVID-19 vaccine has increased reports of post-immunization follow-up events, one of which is urticaria. This study aimed to determine the prevalence and onset of urticaria due to the administration of the COVID-19 vaccine. Methods: This study used a rapid review method based on previous research on the prevalence and onset of urticaria due to the COVID-19 vaccine. The articles were obtained from the PubMed and Google Scholar databases. The inclusion criteria were articles containing data on the prevalence and onset of urticaria due to the COVID-19 vaccine, published from December 2020 – January 2022. Results: From the search results and article selection, 20 articles were included in this study. There are 7 articles containing prevalence data, 11 articles containing onset data, and 2 articles containing prevalence and onset data. Research in these articles was conducted in several different countries. There were seven types of vaccine used with doses of 1 or 2. The sample age ranged from 16 to 76 years. In all of the articles, the sample and the incidence of urticaria were mostly female. There were a history of allergies and atopic history in the sample studied. Conclusion: The prevalence rate of urticaria in the population given the COVID-19 vaccine ranged from 0.035% to 3.2%. The time of onset of urticaria in the population given the COVID-19 vaccine ranged from 5 minutes to 10 days.
Workforce Stability: Motivation Factors Impacting Satisfaction in the IDD Field
Authors: Velardo Elisa F. , Cymbala Patricia , Rodriguez Anthony M. , Thoma Colleen A. , Palmer Susan B. 
Published: December 2022

Abstract
For decades, individuals who are direct support professionals working with people with intellectual and developmental disabilities (IDD) have been under strain. The current study looked at the prevalent themes that impact workforce stability among providers, advocates, policymakers, and researchers in the field of IDD. The researchers applied Herzberg's two-factor theory of motivation and hygiene factors to data gathered through focus group interviews on workforce challenges and opportunities. Findings revealed that motivational factors relating to employee satisfaction, including organizational culture, retention, and credentialing, were identified as critical to workforce stability.