bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Brazilian-Portuguese version of Moorehead-Ardelt Quality of Life - II among patients with severe obesity
Authors: Cremonesi Mariane Carvalho , Duarte-Guerra Leorides Severo , Pajecki Denis , Santo Marco Aurelio , Neto Francisco Lotufo , Wang Yuan-Pang 
Published: June 2022

Abstract
Background
Improvement in quality of life is a major outcome after bariatric surgery. Reliable and valid tools that evaluate the quality of life are essential for better clinical practice.
Aim
Investigate the reliability and validity of the Moorehead-Ardelt Quality of Life-II (MA-II) among Brazilian-Portuguese-speaking patients with severe obesity.
Methods
The sample was composed of 387 patients (mean age 43 years, 78.8% women, median Body Mass Index [BMI]: 46.5 kg/m2) invited from the waiting list of a university-based bariatric center. In addition, psychiatric comorbidities, the severity of depressive symptoms, and the patient's level of functioning were evaluated by the Structured Clinical Interview (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), and Global Assessment of Functioning (GAF), respectively.
Results
The internal consistency of the MA-II was acceptable, as indicated by Cronbach's alpha coefficient of 0.70. The total score of MA-II was significantly correlated with the severity of the depressive symptoms (MADRS) and the level of global functioning (GAF). In turn, the BMI was inversely correlated with physical activity and job performance dimensions of the MA-II. The more BMI increases, the quality of life worsens.
Conclusion
The MA-II is a reliable and valid instrument to evaluate the quality of life among Brazilian-Portuguese-speaking patients with severe obesity. The questionnaire is a helpful and quick tool for assessing the quality of life of bariatric patients.
Expanded sequence space of radical S-adenosylmethionine-dependent enzyme involved in post-translational macrocyclization
Authors: He Bei-Bei , Cheng Zhuo , Zhong Zheng , Gao Ying , Liu Hongyan , Li Yong-Xin 
Published: June 2022

Abstract
Ribosomally synthesized and post-translationally modified peptide (RiPP) represents one of the largest yet largely underexplored natural product families in bacteria. Although varied precursors and maturases lead to remarkable structural diversity, genetically-encoded nature of RiPP results in a residue-defined modification landscape of macrocyclic peptides, which simplifies the prediction and prioritization of their biosynthetic gene clusters (BGCs). Here, we report a small peptide and enzyme co-occurrence analysis workflow (SPECO), which enabled us to perform a large-scale analysis of radical S-adenosylmethionine (rSAM) enzyme-catalyzed RiPPs BGCs and disclosed uncharted enzyme sequence space for unprecedented post-translational modification of macrocyclic peptides. Applying this approach to 161,954 bacterial genomes, we identified 32,220 BGCs of rSAM-catalyzed RiPPs and prioritized 25 new families with unseen biosynthetic architectures or precursor peptide patterns. We further discovered three new enzymes for macrocyclic peptides construction, which catalyzed crosslinks between cysteine to glycine, histidine to aliphatic side-chain, and tyrosine/histidine to arginine, respectively. Together, these results demonstrate the strength of our SPECO approach in discovering new RiPP BGCs and diverse enzymes for macrocyclic peptides biosynthesis.
Work environment disruption and its impact on the workers’ mental wellbeing: An analysis of anxiety and stress in remote e-workers during covid-19 pandemic in India
Authors: Mir Mohd Saleem , Sidana Karan , Sharan Utkarsh , Kumar Rachit , Vibhore Aman , Kumar Lalit , Singh Ojasva , Kumar Sidhant 
Published: June 2022

Abstract
Amidst the disruption of the Coronavirus pandemic the lockdown was established to curb the spread of the disease, resulting in an indirect effect on the well-being of the general populace. For working professionals, who were forced to shift to e-working from home, the home confinement, isolation and disruption of daily routine reinforced new occupational stressors which lead to a rise in reporting of anxious tendencies related to Covid-19. This study is designed to assess the impact of the Covid-19 pandemic on the mental wellbeing of remote e-workers. The study opts for a survey-based research and measures anxiety related to Covid-19 and job stress through Covid-19-related Anxiety Stress (CAS-7) and new Job Stress Scale (JSS-22) standardized instruments. For a sample of 79 respondents, a moderate Covid-19 related anxiety and Job Stress was observed. The mean score for the CAS was 18.31 ± 3.46 indicating a moderate Covid-19 related anxiety. Further, a noticeable trend was observed in the subscales of the Job Stress Scale where mean Job Stress was 12.32 ± 3.87; and Role Expectation Conflict was 13.86 ± 4.87. Coworker Support was 15.92 ± 4.54 and for Anxiety the score was 12.39 ± 5.15. The overall results of job stress scale indicate a moderate occupational anxiety and stress. Age, gender and the work experience are seen to have varied impacts on the anxiety and stress in e-workers. The study adds support to extending the literature that emphasizes implementation of policies for an improved mental and psychological well-being in the situation like COVID-19 pandemic and in such future disruptive events.
An Efficient Weighted Network Centrality Approach for Exploring Mechanisms of Action of the RP-RB Herbal Formula for Treating Rheumatoid Arthritis
Authors: Ochieng Peter , Dombi J´ozsef , Hussain Abrar 
Published: June 2022

Abstract
Aim : This study presents an efficient weighted network centrality measureapproach and its application in network pharmacology for exploring mechanismsof action of the Ruellia prostrata (RP) and Ruellia bignoniiflora (RB) herbalformula for treating rheumatoid arthritis. Method: A tripartite network of RP-RB compositive compound-knowntherapeutic targets-putative target genes was first built. The interconnectivityscore was used to prioritizes network candidate network components based ontheir overall connectivity with shared neighborhood network components. A newinterconnectivity based weighted centrality score calculated from traditionalnetwork centrality measure was used identify and explore relationships of themajor network components. The functionality of our proposed method wasdemonstrated by an application in network pharmacology. Result : Network pharmacology results revealed that out of 196 compounds 22were actively interacting with known rheumatoid arthritis therapeutic targets andputative target genes. A multi-level network simulation identifies 33 majorcandidate targets including 8 compositive compounds, 10 therapeutic targets and15 putative target genes. The gene ontology and KEGG pathway enrichmenttarget validation demonstrated that candidate putative target genes were frequently involved in TNF, CCR5, IL-17 and G-protein coupled receptorssignaling pathways which are critical in the progression of rheumatoid arthritis.The molecular docking simulation and molecular descriptor analysis indicatedthat Glyceryl diacetate-2-Oleate, Hexadecanoic acid, 2,3-bis(acetyloxy)propylester, Glycidyl oleate, and Oleoyl chloride had a high binding affinity on theirmajor targets with their molecular descriptor properties indicating their potentialdrug likeliness for the treatment of rheumatoid arthritis. Conclusion : The findings of this study provides promising results that couldlead to design and discovery alternative drug compounds for management andtreatment of rheumatoid arthritis. Although our approach is purely based on insilico method, clinical experiments are still needed to test and validate thehypotheses of our computational methods.
Prevalence of Cardiac Risk Factors Among ST-Elevation Myocardial Infarction (STEMI) Patients at Damascus Hospital
Authors: Kadoura Hadeel , Muhammed Jinan , Shamia Marwan 
Published: June 2022

Abstract
Introduction:
ST-segment elevation myocardial infarction (STEMI) emergency care networks aim to reduce ischemic times. The influence of risk factors such as sex, age, social habits on prognosis is still being debated. Over half of (STEMI) cases occur in adults < 65 years old, with approximately 10% of all STEMIs affecting individuals < 45 years of age. Therefore, this study aims to assess the prevalence of myocardial risk factors on STEMI patients at Damascus hospital.
Methods
A retrospective study was conducted during the years 2020–2022. All patients with STEMI admitted to cardiovascular department of Damascus hospital were included. Chi-square analysis was used to compare Infarction type and age categories with sociodemographic factors and patients’ medical history variables. One-way analysis of variance (ANOVA) and t-test were used to compare means of continuous variables (Age, smoking period).
Results
of 150 patients, 123 (82%) were males, and 27 (18%) were females. Most of patients aged between 51 and 60 years respectively. 105 (70%) of the patients were smokers, 37 (67.3%) had diabetes, and 47 (31.3%) had hypertension. Most of STEMI patients aged 41–50 years were significantly associated with male sex. The majority of patients aged 30–40 were significantly associated with smokers (p < 0.05).
Conclusion
These findings indicate a high burden of risk factors in younger adults with STEMI. Programs to target sociodemographic factors including smoking, obesity, and comorbid diseases, are necessary to more effectively address health disparities in STEMI and its adverse consequences.
Markers of hemostasis activation and endothelial damage in patients with active cancer
Authors: Dobrovolsky A. B. , Fedotkina Yu. A. , Titaeva E. V. , Frolkova O. O. , Panchenko E. Р. 
Published: June 2022

Introduction. Increased expression of tissue factor by tumor cells, formation of procoagulant microparticles and secretion of proinflammatory cytokines that activate leukocytes and endothelial cells are considered to be the main factors provoking blood coagulation activation in cancer patients.The aim of the investigation was to study the peculiarities of hemostasis activation markers and endothelial damage in patients with active cancer.Materials and methods. Patients with active cancer were included in the study. We determined the following biomarkers: fibrinogen (Fg), von Willebrand factor (vWF), D-dimer (D-d), growth differentiation factor 15 (GDF-15), vascular endothelial growth factor A (VEGF-A).Results. Twenty-two patients with active cancer were included in the study. The median follow-up of the patients was 180 days (minimum 90, maximum 240). The presence of metastatic lesion was found in 62% of patients. At the end of the follow-up period (after 6 months) remission of the underlying disease was observed in 45.5% of patients, and 54.5% of patients were found to have progressed oncoprocess. GDF-15 levels ranged from 1486 to 11,722 pg/ml and were above normal values in all patients. Significant variability was also revealed in the level of VEGF-A - from 1 to 2944 pkg/ml, and only in 7 (32%) patients its level corresponded to normal values (0-66 pkg/ml). High levels of Fg (>3.6 g/L), D-d (>500 ng/ml), and vWF (>160%) were detected in 19 (86%), 18 (82%), and 17 (77%) patients, respectively.Conclusions. The pilot study demonstrates a pronounced activation of the blood coagulation system and endothelial damage in patients with active cancer receiving chemotherapy and having a high risk of venous thromboembolic complications. The detected relationship of markers characterizing blood coagulation activation (D-d) and endothelial damage (vWF) with the progression of oncoprocess necessitates their further study in this category of patients.
Los elementos didácticos del aprendizaje móvil: condiciones en que el uso de la tecnología puede apoyar los procesos de enseñanza y aprendizaje
Authors: Balanyà Rebollo Judith , De Oliveira Janaina Minelli 
Published: June 2022

El objetivo de este trabajo es analizar las condiciones en que el uso de la tecnología puede apoyar los procesos de enseñanza y aprendizaje para brindar a los docentes acciones específicas a considera. Por lo tanto, nos planteamos dos preguntas de investigación que se responden en este artículo: 1. ¿Cuál es el marco teórico apropiado para las actividades de diseño del aprendizaje móvil?, y 2. ¿Cómo se pueden agrupar los factores cruciales que afectan el aprendizaje móvil en una taxonomía comunitaria? Se recurre a la metodología “Investigación basada en el diseño” (Pool & Laubscher, 2016) que nos ha permitido secuenciar el proceso por fases: este artículo presenta la primera fase del proceso de validación de los elementos didácticos del aprendizaje móvil seleccionados de la revisión de la literatura, revisión sistemática y basada en evaluación de juicio de expertos. Los principales resultados determinaron los elementos pedagógicos que apoyan el proceso de diseño, implementación y evaluación del aprendizaje con dispositivos móviles en educación: 1. El contenido, 2. Las estrategias metodológicas, 3. Las actividades, 4. La evaluación, 5. Los recursos tecnológicos del aprendizaje, 6. Los recursos móviles y 7. El docente.
Enseñanza flexible y aprendizaje de la matemática en educación secundaria rural
Authors: Vilchez Guizado Jesús , Ramón Ortiz Julia Ángela 
Published: June 2022

La pandemia de covid-19 obligó la implementación de nuevas estrategias de enseñanza y aprendizaje, como la enseñanza flexible y el uso generalizado de la tecnología digital. El objetivo de este trabajo es analizar las implicaciones de la enseñanza flexible de la matemática en el logro del aprendizaje de los estudiantes del quinto grado de educación secundaria, en el contexto de los colegios rurales de la provincia de Huánuco 2021. El estudio se enmarca dentro de un enfoque mixto, a través de un diseño no experimental, con monitoreo personalizado de las actividades de enseñanza-aprendizaje que fueron validadas mediante un cuestionario de preguntas y evaluación aplicado a 36 estudiantes, entrevista a 5 estudiantes y 2 profesores. Los resultados muestran que el 72% de los estudiantes se muestran conformes con la enseñanza flexible recibida, y más del 67% tuvieron logro esperado y destacado en el aprendizaje de los contenidos matemáticos impartidos de manera personalizada, resultado que es corroborada con las respuestas obtenidas en la entrevista. Se concluye que, la enseñanza flexible se relaciona directamente e influye de manera positiva en el proceso de aprendizaje de la matemática de los estudiantes del quinto grado de secundaria del ámbito rural.
Aula invertida gamificada como estrategia pedagógica en la educación superior: Una revisión sistemática
Authors: Carpena Arias Jesús , Esteve Mon Francesc 
Published: June 2022

La estrategia metodológica aula invertida gamificada es un enfoque pedagógico que actualmente está ganando terreno en la educación superior. Dicha estrategia está compuesta por el aula invertida y la gamificación. Ambas experiencias metodológicas permiten una mayor participación del alumnado en la dinámica de la clase. La presente revisión sistemática presenta de manera exploratoria el uso del flipped learning (FL) junto a la gamificación en la etapa universitaria. Para ello se han revisado un total de 58 artículos, aportaciones indexadas en Scopus, ERIC y WoS hasta el 2021.
Los resultados demuestran que las publicaciones se centran en su mayoría en conocer el aspecto motivacional y la participación tras implementar la estrategia pedagógica aula invertida gamificada en la etapa universitaria. Podemos deducir pues, la importancia de combinar el aula invertida con la gamificación ya que tienen aspectos positivos relacionados con la motivación, el rendimiento académico y la autonomía.
Beneficial effect of climate change on wheat yield and water footprints in the Middle-Manyame sub-catchment, Zimbabwe
Authors: Govere Simbarashe , Nyamangara Justice , Nyakatawa E. Z. 
Published: June 2022

Abstract
Climate change is a major concern in wheat agroecosystems as it can affect productivity and crop water use. This study used the AquaCrop model to evaluate climate change impacts on the wheat yield, crop water use and water footprint of wheat production in the Middle-Manyame sub-catchment of Zimbabwe. Climate scenarios were based on simulations from the NCC-NorESM1-M, CCCma-CanESM2 and MOHC-HadGEM2-ES General Climate Models downscaled using three Regional Climate Models (RCA4, RegCM4 and CRCM5) under two Representative Concentration Pathways (RCP4.5 and RCP8.5). The results showed that, compared to the baseline climate (1980–2010), yield may increase by 22.60, 29.47 27.80, and 53.85% for the RCP4.5 2040 s, RCP4.5 2080 s, RCP8.5 2040 s and RCP8.5 2080 s scenarios, respectively. Crop water use may decrease by 1.68, 1.25, 3.7 and 6.47%, respectively, under the four scenarios, respectively. Consequently, the blue water footprint may decrease by 19, 23, 24 and 38%, respectively, under the four scenarios. Sensitivity analysis attributed the increase in yields and the decrease in crop water use to the CO2 fertilization effect, which had a dominant effect over high-temperature effects. The results suggest that future wheat yields could be enhanced while crop water use is reduced because of climate change. However, the realization of these benefits requires farmers to adapt to climate change by adopting recommended agronomic practices and farm input rates that are consistent with those used in the modelling approach of this study.
Francesco Filelfo e gli Jagelloni: un umanista italiano sulla scena europea
Authors: Costanza Salvatore 
Published: June 2022

Francesco Filelfo (Tolentino 1398- Florence 1481) was an Italian humanist who studied Greek in Padua, Venice and Constantinople, where he lived during his youth (1420-´27). He is known for his giant Collection of Latin and Greek Letters in 48 books. He also became acquainted with the most prominent personalities of philology, arts and politics at his time. Among them, we must count Władysław II Jagiełło (Vilnius 1362 - Gródek 1434), the granduke of Lithuania (1377-1434) and then king of Poland (since 1386). Filelfo encountered the old king in Buda at the Emperial Diet (1423), in which he took part as personal secretary of the Byzantine ruler John VIII Palaiologos. The Polish king was impressed by Filelfo´s unusual culture and brilliance so to invite him at his fourth marriage with Zofia Holsańska (ca. 1405-1461). The Italian humanist went to royal wedding held in Kraków, where he pronounced an official epitalamium, as he proudly writes to Władysław III Jagiełło born from this union. He sent this long letter to the young king of Poland just on the eve of the battle in Warna (1444), in which the latter heroically died fighting with Turks. Filelfos epistle to Władysław III influenced Polish humanists such as Albertus Brucius and Jan Ursyn. It is interesting to remark the role that Filelfo assigned to Polish nation as defender of Freedom against Ottoman expansion into Europe.
Anti-Monopoly and Competition Laws - Impact on the Indian Pharmaceutical Industry
Authors: Kaushik Prerna , Tripathy Swagat , Sharma Rishi , Dureja Harish 
Published: June 2022

Background:
Competition is a process of economic race between market participants to draw clients. The Indian competition law establishment is an early administration. Before the enactment of the Competition Act in May 2002, Monopolistic and Restrictive Trade Practices (MRTP) Act was the active law that managed certain parts of the opposition.

Objective:
This manuscript highlights the purpose of competition laws for grappling with the monopolies and restrictive trade practices with a particular focus on pharmaceuticals.

Conclusion
The Competition Act highlights the main features of new competition law which put back the old MRTP act and also lets in the proscription of anti-competitive treaties, prevention of misuse of dominance and combinations which prove detrimental to the competition in the market.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS AUDIO-VISUAL UNTUK E-LEARNING MATA KULIAH KURIKULUM DAN PEMBELAJARAN AKUNTANSI
Authors: Siswanto Siswanto , Aghni Rizqi Ilyasa , Siregar Merinda Noorma Novida 
Published: June 2022

Tujuan dilaksanakannya penelitian ini adalah untuk mengetahui apakah: 1) Mengetahui tahap pengembangan serta menghasilkan media pembelajaran berbasis audio-visual untuk e-learning mata kuliah kurikulum dan pembelajaran Akuntansi, 2) Menghasilkan media pembelajaran berbasis audio-visual untuk e-learning yang layak pada mata kuliah kurikulum dan pembelajaran Akuntansi dari segi ahli, praktisi, dan mahasiswa. Penelitian ini merupakan penelitian pengembangan dengan teknik analisis data deskriptif. Data penelitian diperoleh dari hasil penilaian ahli (validator) terhadap perangkat pembelajaran yang meliputi media pembelajaran yang dikembangkan berupa modul PDF, powerpoint bersuara, dan video animasi. Analisa data dilakukan untuk mengetahui kelayakan dari media pembelajaran yang dikembangkan dengan mengkonversi data hasil uji coba pada skala lima. Hasil penelitian dan pengembangan ini adalah: (1) pengembangan media pembelajaran berbasis audio-visual untuk e-learning mata kuliah kurikulum dan pembelajaran akuntansi. Model pengembangan yang digunakan yakni Model 4 D, yang terdiri dari Define, Design, Development, dan Disemination. (2) Kelayakan media pembelajaran menurut ahli materi, ahli media, dan dosen pengampu baik untuk media modul PDF, PPT bersuara, dan video animasi ditinjau dari berbagai aspek penilaian masuk dalam kategori “sangat layak”. (3) Berdasarkan hasil respon mahasiswa terhadap penggunaan berbagai media pembelajaran tersebut pada kategori sangat layak untuk modul PDF, sedangkan kategori layak untuk media PPT bersuara dan video animasi. Kata Kunci : Media Pembelajaran, Audio-Visual, Kurikulum dan Pembelajaran Akuntansi
INFLUENCE OF ATMOSPHERIC AIR POLLUTANTS ON THE PREVALENCE OF ENDOCRINE DISEASES IN CHILDREN AND ADOLESCENTS IN THE INDUSTRIAL CITY
Authors: Sincere O. M. , Kapranov S. V. , Kapranova T. S. 
Published: June 2022

The influence of air pollutants on the prevalence of endocrine diseases in children and adolescents in an industrial city with large productions of ferrous metallurgy and coke chemistry has been studied. It is established that the prevalence of endocrine diseases, disorders
nutrition and metabolism, as well as the prevalence of thyroid pathology is higher in children attending children's educational institutions in areas with high levels of pollution
atmosphere, compared with their peers who visit children's institutions in neighborhoods with more
clean air. Preventive recommendations have been developed.
INFLUENCE OF TAURINE-CONTAINING DRUG ON THE DEVELOPMENT OF VISCERAL OBESITY IN OVARIECTOMED RATS WITH SYNDROME INSULIN RESISTANCE INDUCED BY A HIGH FAT DIET
Authors: Zvyagina T. S. , Gorbenko Nataliia 
Published: June 2022

The effect of taurine-containing drug on the development of visceral obesity in rats was studied
with the syndrome of insulin resistance on the background of estrogen deficiency, which was kept on a high-fat diet. It was found that oral administration of taurine-containing drug, in the absence of
stimulating effect on proliferative processes in the uterus, improves tolerance to
carbohydrates and sensitivity to insulin, inhibits the development of abdominal obesity, weight gain
body. The obtained results substantiate the prospects of using taurine-containing drug for pharmacological correction of the main components of postmenopausal metabolic
syndrome.