bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autonomic changes as reaction to experimental social stress in an inpatient psychosomatic cohort
Authors: Thurner Carolin , Horing Bjoern , Zipfel Stephan , Stengel Andreas , Mazurak Nazar 
Published: August 2022

ObjectivesPatients with psychosomatic disorders suffer from social isolation that might further lead to destabilization and exacerbation of bodily symptoms via autonomic pathways. We aimed to investigate the influence of controlled social stress (model of social ostracism) on the autonomic nerve system (ANS) in an inpatient cohort with psychosomatic disorders.MethodsWe examined heart rate variability (HRV), skin conductance (SC) and skin temperature (ST) as well as ECG-derived respiration rate (EDR) and subjective reports on stress during exposure to experimental social stress (cyberball game). Data were collected from 123 participants (f:m = 88:35, 42.01 ± 13.54 years) on admission and upon discharge from the university psychosomatic clinic. All data were recorded during baseline, inclusion and exclusion phases of the cyberball game as well as during the recovery phase.ResultsWe found significant changes between admission and discharge with a decline in parasympathetic-related HRV parameters (SDRR −3.20 ± 1.30 ms, p = 0.026; RMSSD: −3.77 ± 1.28 ms, p = 0.007) as well as a decrease in SC (−0.04 ± 0.17 μS, p = 0.019) and EDR (−0.01 ± 0.01 Hz, p = 0.007), suggesting a drop in sympathetic tonus, with no changes in ST (p = 0.089) and subjective stress levels (p = 0.322). HRV parameters decreased during the cyberball game (SDRR p = 0.026; RMSSD p = 0.002; lnHF p &lt; 0.001). In contrast, both SC (p &lt; 0.001) and EDR (p &lt; 0.001) increased during the game with SC being slightly lower during the exclusion phase. This can point toward a stimulation of sympathetic nervous system during game participation, which was concordant with the rise in subjective stress values (p &lt; 0.001). ST showed a continuous, unspecific rise over time (p &lt; 0.001).ConclusionOur data demonstrate the decrease of ANS parameters during experimental social stress when data upon discharge were compared to those upon admission. These results are partially contradictory to previous studies that showed a rise in HRV in a psychiatric cohort over the course of (outpatient) treatment. Further research is required to help attributing these differences to effects of treatment or acute states relating to admission to or discharge from a psychosomatic department.
Effect of Nurses' Work Experiences in a COVID-19 Unit on Depression: Mediation Effect of Resilience and Moderated Mediation Effect of Organizational Trust
Authors: Doo Eun-Young , Choi Sujin 
Published: August 2022

AimNurses work with a lack of organizational support and perceive an unsafe environment from their organizations, which has been related to depression. This study aimed to investigate the effect of nurses' work experiences in a COVID-19 unit on their depression, the mediation effect of resilience, and the moderated mediation effect of organizational trust.MethodsParticipants were 132 nurses working at a general hospital. Through questionnaires, data were collected during the COVID-19 pandemic and analyzed using SPSS 25.0 and SPSS PROCESS macro.ResultsMean resilience was 2.15 ± 0.76; mean organizational trust was 3.03 ± 0.74; mean depression was 0.76 ± 0.63. 65.6% nurses with work experience in a COVID-19 unit had depression. Of the 27.2% nurses who showed moderate or higher levels of depression. Nurses' work experiences in a COVID-19 unit had a direct effect on depression and indirectly affected depression via resilience as a mediator. Resilience had a partial mediation effect, and organizational trust had a significant moderated mediation effect in the path from nurses' work experiences in a COVID-19 unit to depression mediated by resilience.ConclusionsThis study emphasizes the key role that healthcare organizations play in providing sufficient support to nursing staff to protect them from depression by improving nurses' resilience and organizational trust during the pandemic. Healthcare organizations need to develop a systematic structure to provide organizational support to nurses so that the organizational trust and resilience of nurses can be maximized.
Effects of social participation patterns and living arrangement on mental health of Chinese older adults: A latent class analysis
Authors: Chen Jieyao , Zeng Yanbing , Fang Ya 
Published: August 2022

ObjectivesThe purpose of this study was to discover patterns of social participation among Chinese older individuals, investigate the links between these patterns and their living arrangements and mental health, and connect these patterns to their background characteristics.MethodsData were drawn from the 2014 and 2018 waves of Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2537 Chinese elders aged 60 years and over at the baseline. Latent class analysis was used to determine the patterns of social participation. Multinomial logistic regression was used to explore the relationship between patterns of social participation and the sociodemographic and health characteristics of older adults. Binary logistic regression was used to explore the differences and associations between these categories and living arrangement on mental health status, represented by positive and negative emotions.ResultsThree patterns of social participation were identified: Low activity (17.5%, n = 443); Moderate activity (36.2%, n = 1,176); and High activity (46.3%, n = 918). At baseline, these patterns were significantly associated with mental health status. Positive and negative emotions were much better in the High activity group than in the other two groups (OR = 1.36, 95% CI = 1.05–1.76 and OR = 1.50, 95% CI = 1.16–1.93). Living arrangement only significantly affected negative emotions (OR=1.25, 95% CI = 1.02–1.53). Age, gender, education, marital status, self-rated health, and activities of daily living limitations all affected social participation patterns.ConclusionsThe patterns of social participation and living arrangement of Chinese older adults are significantly associated with mental health. Population-tailored interventions may help liberate older adults from domestic labor and improve social participation. Moreover, family support can decrease negative emotions' damage in old age thus promoting health.
Quantifying the future risk of dengue under climate change in Japan
Authors: Hayashi Katsuma , Fujimoto Marie , Nishiura Hiroshi 
Published: August 2022

BackgroundIn metropolitan Tokyo in 2014, Japan experienced its first domestic dengue outbreak since 1945. The objective of the present study was to quantitatively assess the future risk of dengue in Japan using climate change scenarios in a high-resolution geospatial environment by building on a solid theory as a baseline in consideration of future adaptation strategies.MethodsUsing climate change scenarios of the Model for Interdisciplinary Research on Climate version 6 (MIROC6), representative concentration pathway (RCP) 2.6, 4.5, and 8.5, we computed the daily average temperature and embedded this in the effective reproduction number of dengue, R(T), to calculate the extinction probability and interepidemic period across Japan.ResultsIn June and October, the R(T) with daily average temperature T, was &lt;1 as in 2022; however, an elevation in temperature increased the number of days with R(T) &gt;1 during these months under RCP8.5. The time period with a risk of dengue transmission gradually extended to late spring (April–May) and autumn (October–November). Under the RCP8.5 scenario in 2100, the possibility of no dengue-free months was revealed in part of southernmost Okinawa Prefecture, and the epidemic risk extended to the entire part of northernmost Hokkaido Prefecture.ConclusionEach locality in Japan must formulate action plans in response to the presented scenarios. Our geographic analysis can help local governments to develop adaptation policies that include mosquito breeding site elimination, distribution of adulticides and larvicides, and elevated situation awareness to prevent transmission via bites from Aedes vectors.
Rancang Bangun Sistem Automatic Semi Returnless Berbasis Arduino Uno pada Engine Caterpillar C27 Studi Kasus PT. Saptaindra Sejati
Authors: Sukisno Sulis Widi Achmad , Suparno Joko , Ardiansyah Dimas 
Published: August 2022

Pump units with a Caterpillar C27 engine with an EUI (Electronic Unit Injector) fuel system that often has low power due to filter clogging at PT. Sapta Indra Sejati. Filter cloggingoccurs due to due to the thickened biofuel content and creates a crust. If the machine has a problem, the mining process can be disrupted because the coal loading area is flooded. This study aims to create an additional system in the form of a automatic semi-returnless where the fuel return line is changed automatically into the filter because the fuel return is clean. The movement of the return control valve is regulated by a microcontroller which is programmed according to specifications and needs. The microcontroller used is Arduino Unowith pressure and temperature sensors. Arduino Uno is programmed when the engine will experience low power with a fuel pressure of 400 kPa then the return path is changed to semi returnless. With a change in the semi returnless path, the pressure becomes stable at 380 kPa and the engine RPM is stable with power that is still maintained. The advantages of semi-returnless system are that filter replacement costs can be reduced and production time is not interrupted.
Chronic Myeloid Leukemia: Part I—Real-World Treatment Patterns, Healthcare Resource Utilization, and Associated Costs in Later Lines of Therapy in the United States
Authors: Atallah Ehab L. , Maegawa Rodrigo , Latremouille-Viau Dominick , Rossi Carmine , Guérin Annie , Wu Eric Q. , Patwardhan Pallavi 
Published: August 2022

Background: Despite advances in tyrosine kinase inhibitor (TKI) therapy for chronic myeloid leukemia in chronic phase (CML-CP), a sizeable proportion of patients with CML-CP remains refractory or intolerant to these agents. Objectives: Treatment patterns, healthcare resource utilization (HRU), and costs were evaluated among patients with CML who received third or later lines of therapy (3L+), a clinical population that has not been previously well-studied, with unmet treatment needs as TKI therapy has repeatedly failed. Methods: Adult patients with CML who received 3L+ were identified in the IBM® MarketScan® Databases (January 1, 2001–June 30, 2019) and the SEER-Medicare–linked database (January 1, 2006–December 31, 2016). Treatment patterns were observed from CML diagnosis. HRU and direct healthcare costs (payer’s perspective, 2019 USD) were measured in a 3L+ setting. Results: Among 296 commercially insured patients with 3L+ (median age, 58.5 years; female, 49.7%), the median duration of first-line (1L), second-line (2L), and 3L therapy was 8.5, 4.2, and 8.3 months, respectively. The annual incidence rate during 3L+ was 3.4 for inpatient days, 30.8 for days with outpatient services, and 1.2 for emergency department visits. Mean per-patient-per-month (PPPM) total healthcare costs (pharmacy + medical costs) were $18 784 in 3L+, $15 206 in 3L, and $19 546 in 4L, with inpatient costs driving most of the difference between 3L and 4L (mean [3L] = $2528 PPPM, mean [4L] = $6847 PPPM). Among 53 Medicare-insured patients with 3L+ (median age, 72.0 years; female, 39.6%), the median duration of 1L, 2L, and 3L therapy was 9.7, 5.0, and 7.0 months, respectively. During 3L+, the annual incidence rate was 10.3 for inpatient days, 61.9 for days with outpatient services, and 1.5 for emergency department visits. Mean PPPM total healthcare costs were $14 311 in 3L+, $15 100 in 3L, and $16 062 in 4L. Discussion: Patients with CML receiving 3L+ rapidly cycled through multiple lines. Costs increased from 3L to 4L; in commercially insured patients, inpatient costs were responsible for most of the cost increase between 3L and 4L, underlying these patients’ continued need for care. Conclusions: These findings support the need for better treatment options in patients with CML undergoing later lines of therapy.
PENGARUH KONSENTRASI MENTOL SEBAGAI PENETRANT ENHANCER TERHADAP SEDIAAN GEL SODIUM DIKLOFENAK
Authors: Maulina Novia 
Published: August 2022

Sodium diklofenak adalah satu obat golongan NSAID non selektif dengan koefisien partisi sebesar 13,4, yang membuat penetrasi pada stratum korneum kurang optimal. Sehingga diperlukan bahan yang dapat membantu dalam meningkatkan penetrasi, salah satunya ialah dengan menambahkan penetrant enhancer. Tujuan dari penelitian ini untuk melihat pengaruh penambahan mentol sebagai penetrant enhancer dengan kadar 0; 0,5; 0,75; 1% terhadap sediaan gel sodium diklofenak pada uji penetrasi metode sel difusi Franz. Uji sediaan dilakukan dengan metode sel difusi Franz pada membran kulit tikus Wistar jantan bagian abdomen. Uji statistik one way ANOVA (P<0.05) menunjukkan bahwa penambahan mentol 0; 0,5; 0,75; 1% tidak ada pengaruh pada nilai fluks sediaan dan permeabilitas membran. Formula I, II, III, dan IV tidak berpengaruh terhadap nilai fluks sodium diklofenak dan permeabilitas membran.
Gas Dynamics and Star Formation in NGC 6822
Authors: Park Hye-Jin , Oh Se-Heon , Wang Jing , Zheng Yun , Zhang Hong-Xin , De Blok W. J. G. 
Published: August 2022

Abstract
We present H i gas kinematics and star formation activities of NGC 6822, a dwarf galaxy located in the Local Group at a distance of ∼490 kpc. We perform profile decomposition of line-of-sight velocity profiles of the H i data cube (42.4″ × 12.0″ spatial, corresponding to ∼100 pc; 1.6 km s−1 spectral) taken with the Australia Telescope Compact Array. For this, we use a new tool, the so-called baygaud, which is based on Bayesian analysis techniques, allowing us to decompose a line-of-sight velocity profile into an optimal number of Gaussian components in a quantitative manner. We classify the decomposed H i gas components of NGC 6822 into cool-bulk, warm-bulk, cool-non-bulk, and warm-non-bulk motions with respect to their centroid velocities and velocity dispersions. We correlate their gas surface densities with corresponding star formation rate densities derived using both the GALEX far-ultraviolet and WISE 22 μm data to examine the resolved Kennicutt–Schmidt (K-S) law for NGC 6822. Of the decomposed H i gas components, the cool-bulk component is likely to better follow the linear extension of the K-S law for molecular hydrogen (H2) at low gas surface densities where H i is not saturated.
A Uniform Type Ia Supernova Distance Ladder with the Zwicky Transient Facility: Absolute Calibration Based on the Tip of the Red Giant Branch Method
Authors: Dhawan Suhail , Goobar Ariel , Johansson Joel , Jang In Sung , Rigault Mickael , Harvey Luke , Maguire Kate , Freedman Wendy L. , Madore Barry F. , Smith Mathew , Sollerman Jesper , Kim Young-Lo , Andreoni Igor , Bellm Eric C. , Coughlin Michael W. , Dekany Richard , Graham Matthew J. , Kulkarni Shrinivas R. , Laher Russ R. , Medford Michael S. , Neill James D. , Nir Guy , Riddle Reed , Rusholme Ben 
Published: August 2022

Abstract
The current Cepheid-calibrated distance ladder measurement of H
0 is reported to be in tension with the values inferred from the cosmic microwave background (CMB), assuming standard cosmology. However, some tip of the red giant branch (TRGB) estimates report H
0 in better agreement with the CMB. Hence, it is critical to reduce systematic uncertainties in local measurements to understand the Hubble tension. In this paper, we propose a uniform distance ladder between the second and third rungs, combining Type Ia supernovae (SNe Ia) observed by the Zwicky Transient Facility (ZTF) with a TRGB calibration of their absolute luminosity. A large, volume-limited sample of both calibrator and Hubble flow SNe Ia from the same survey minimizes two of the largest sources of systematics: host-galaxy bias and nonuniform photometric calibration. We present results from a pilot study using the existing TRGB distance to the host galaxy of ZTF SN Ia SN 2021rhu (aka ZTF21abiuvdk) in NGC7814. Combining the ZTF calibrator with a volume-limited sample from the first data release of ZTF Hubble flow SNe Ia, we infer H
0 = 76.94 ± 6.4 km s−1 Mpc−1, an 8.3% measurement. The error budget is dominated by the single object calibrating the SN Ia luminosity in this pilot study. However, the ZTF sample includes already five other SNe Ia within ∼20 Mpc for which TRGB distances can be obtained with the Hubble Space Telescope. Finally, we present the prospects of building this distance ladder out to 80 Mpc with James Webb Space Telescope observations of more than 100 ZTF SNe Ia.
Molecular Gas Structures Traced by 13CO Emission in the 18,190 12CO Molecular Clouds from the MWISP Survey
Authors: Yuan Lixia , Yang Ji , Du Fujun , Su Yang , Liu Xunchuan , Zhang Shaobo , Sun Yan , Zhou Xin , Yan Qing-Zeng , Ma Yuehui 
Published: August 2022

Abstract
After morphological classification of 18,190 12CO molecular clouds, we further investigate the properties of their internal molecular gas structures traced by the 13CO (J = 1−0) line emissions. Using three different methods to extract the 13CO gas structures within each 12CO cloud, we find that ∼15% of the 12CO clouds (2851) have 13CO gas structures and these 12CO clouds contribute about 93% of the total integrated flux of 12CO emission. In each of the 2851 12CO clouds with 13CO gas structures, the 13CO emission area generally does not exceed 70% of the 12CO emission area, and the 13CO integrated flux does not exceed 20% of the 12CO integrated flux. We reveal a strong correlation between the velocity-integrated intensities of 12CO lines and those of 13CO lines in both 12CO and 13CO emission regions. This indicates the H2 column densities of molecular clouds are crucial for the 13CO line emission. After linking the 13CO structure detection rates of the 18,190 12CO molecular clouds to their morphologies, i.e., nonfilaments and filaments, we find that the 13CO gas structures are primarily detected in 12CO clouds with filamentary morphologies. Moreover, these filaments tend to harbor more than one 13CO structure. That demonstrates filaments not only have larger spatial scales, but also have more molecular gas structures traced by 13CO lines, i.e., local gas density enhancements. Our results favor the turbulent compression scenario for filament formation, in which dynamical compression of turbulent flows induces local density enhancements. The nonfilaments tend to be in the low-pressure and quiescent turbulent environments of the diffuse interstellar medium.
Confinement et approvisionnement alimentaire local auprès des circuits courts : une analyse sous l’angle de la proximité
Authors: François-Lecompte Agnès , Prim-Allaz Isabelle , Innocent Morgane , Kreziak Dominique 
Published: August 2022

La crise sanitaire de 2020 et le confinement ont engendré un élan des Français vers les circuits alimentaires courts de proximité : tendance durable ou simple parenthèse ? Cette étude longitudinale montre que ce sont plus particulièrement les motivations de soutien aux producteurs et de changements dans l’alimentation qui conduisent les consommateurs ayant expérimenté ces nouveaux modes d’approvisionnements de proximité à les adopter de façon plus pérenne.
A 6-year audit of public-sector MR utilisation in the Western Cape province of South Africa
Authors: Parak Yusuf , Davis Razaan , Barnard Michelle , Fernandez Amanda , Cloete Keith , Mukosi Matodzi , Pitcher Richard D. 
Published: August 2022

Background: Disparities in MR access between different countries and healthcare systems are well documented. Determinants of unequal access within the same healthcare system and geographical region are poorly understood.Objective: An analysis of public sector MR utilisation in South Africa’s Western Cape province (WCP).Methods: A retrospective study of WCP MR and population data for 2013 and 2018. MR units/106 people, studies, and studies/103 people were calculated for each year, for the whole province and the ‘western’ and ‘eastern’ referral pathways, stratified by age (0–14 years, 14 years)Results: Between 2013 and 2018, the WCP population increased 8% (4.63 vs 5.08 × 106 people) while MR resources were unchanged (‘western’ = 2 units; ‘eastern’ = 1), equating to decreasing access (units/106 people) for the province (0.65 vs 0.59; –9.2%), the ‘western’ (0.97 vs 0.9; –7.2%) and ‘eastern’ (0.39 vs 0.35; -10.3%) pathways. In 2013, 40% (4005/10 090) of studies were in the ‘eastern’ pathway serving 55% (2 066 079/4 629 051) of the population. Between 2013 and 2018 ‘eastern’ population growth (n = 286 781) exceeded ‘western’ (n = 168 469) by 70% (n = 118 312). By 2018, 38% (7939/12 848) of studies were performed in the ‘eastern’ pathway, then serving 56% (2 849 753/5 084 301) of the population. Among 0–14-year-olds, ‘western’ utilisation (studies/103 people) exceeded ‘eastern’ by a factor of approximately 2.4 throughout. In patients 14 years, the utilisation differential increased from 1.78 to 1.98 in the review period.Conclusion: Ensuring equitable services on the same healthcare platform requires ongoing surveillance of resource and population distribution. MR access can serve as a proxy for equity in highly specialised services.
Thoracoscore: Does it predict mortality in the Indian scenario? – A retrospective study
Authors: Pathy Archana , Kar Prachi , Gopinath Ramachandran , Gubba Divya , Soujanya Rani N , Kanimozhi A 
Published: August 2022

Background and Aims:
Preoperative risk stratification helps in better prognostication and allocation of resources. However, risk scoring models are less often used in thoracic surgery. Thoracoscore, a risk score model for thoracic surgery was originally developed on a French population and was later validated in many countries. As there is no literature on its ability to predict mortality in the Indian population, we aimed to validate Thoracoscore in Indian thoracic surgical patients.

Methods:
This retrospective study was carried out in a tertiary care centre after obtaining institutional ethics committee clearance. Patients who were operated for lung pathologies via a posterolateral thoracotomy incision between January 2014 and December 2018 were included in the study. Data on Thoracoscore variables and few additional factors (pulmonary arterial hypertension (PAH), redo surgery, blood loss, blood transfusion, duration of anaesthesia, one lung ventilation and surgery) was collected along with observed mortality statistics. Mortality was predicted using online calculator from the site https://sfar.org/scores2/thoracoscore2.php.Significant continuous and categorical variables in causation of mortality were identified using unpaired t-test and Chi-square tests, respectively. These variables were subjected to multivariate logistic regression to find independent risk factors for mortality. The calibration and discrimination of the Thoracoscore model was analysed by using Hosmer–Lemeshow test and area under the curve of receiver operating characteristic curves.

Results:
Overall observed mortality in the study was 3.2% while predicted mortality was 0.44%. The Thoracoscore had poor calibration and fair discrimination ability. PAH and re-operative surgery along with Thoracoscore were found to be independent risk factors of mortality in thoracic surgery.

Conclusion:
Thoracoscore fails to predict mortality in the Indian population.