bluuebunny/crossref_metadata_2025_split huggingface dataset:
A COVID-19 Follow Up Protocol Based on Short and Long Term Clinical Outcomes
Authors: Kikani Hiral Ashvinbhai , Bhatt Parloop Amit , Bariya Aditi Hemrajbhai , Darji Vinay Chhanalal 
Published: February 2022

Background: Corona virus disease (COVID-19) represents a public health emergency of international concern, with continuously growing number of confirmed and re infected cases.
Main body: Clinical sequels during early COVID-19 convalescence were common; it ranges from mild to moderate respiratory illness associated with pulmonary abnormalities; physical, mental and/or other clinical health outcomes. Older people, males and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, pregnancy and cancer more likely to develop serious complications and poor outcomes. Later on, Mucormycosis complications have been also reported in many hospitals. These complications are observed at short and long term follow up. Thus, a simple, well inferring easy to perform protocol needs to be in place to follow up COVID discharged patients. This review describes the outcomes/complication associated with COVID 19 and its contributory factors. In its context based on available literature and guidelines the review also proposes a post COVID follow up protocol at 7 days, 1 and 3 months after discharge.
Conclusion: COVID-19 the global health issue is severely associated with pulmonary defects, a long quarantine period/hospitalization stay and a possible reactivation of the virus; potential pulmonary, physical and/or psychological outcomes may be anticipated in patients following discharge. Thus, a follow up protocol needs to be implemented at 1 week, 1 and 3 months respectively for the holistic wellbeing of the patient.
Correlation between Polycystic Ovary Syndrome and Periodontal Disease
Authors: Dhakulkar Shamli , Bajaj Pavan , Bhombe Komal 
Published: February 2022

Background: Polycystic ovary syndrome has metabolic and reproductive properties that may be associated with periodontitis. The goal of this study was to reassess and offer a comprehensive critical evaluation of all findings associating Polycystic ovarian syndrome (PCOS) and PD, as well as to analyse a possible two - way relationship. The underlying molecular processes of this link are unknown, but chronic inflammation is considered to be a cause. A pro-inflammatory condition was linked to a changed periodontal response in PCOS, which appeared to enhance vulnerability to periodontal disease. Polycystic ovarian syndrome suffers more than half of all females of childbearing age., and has serious consequences for the metabolic, psychological, and cardiovascular systems. Inflammation is a characteristic sign of PCOS. There may be a role for chronic low-grade inflammation as well in metabolic abnormalities. Hence this review aims to correlate the association between PCOS and Periodontal Disease.
Cytotoxic Activity of Zinc Oxide Nanoparticle Synthesis Using Leaves Extract of Abies webbiana
Authors: Srinisha M. , Jeevitha M. , Rajeshkumar S. , Jayaraman Selvaraj 
Published: February 2022

Aim: The present study aimed to analyse the cytotoxicity of zinc oxide nanoparticles (ZnO NPs) that are biosynthesized using extract of Abies webbiana
Methodology: Zinc oxide nanoparticles were synthesized by green approach using A. webbiana and were characterized by UV- vis spectroscopy. The powdered A. webbiana mediated ZnO NPs were subjected to cytotoxic tests for different concentrations by brine shrimp lethality assay.
Results: ZnO NPs synthesized from A. webbiana showed reduced toxicity at lower concentrations. After 48 hours, it was found that at a minimal concentration of 5 µl, 90% of the nauplii and in concentration of 10 µl and 20 µl, 80% of the nauplii were alive. At a concentration of 40 µl and 80 µl, 70% of the nauplii were alive. Whereas the control showed 100% of the nauplii to be alive.
Conclusion: Various nanoformulations of A. webbiana mediated ZnO NPs can be developed at optimal concentrations for therapeutics that are safe and economical.
Clinical Status of Pregnancy-Induced Hypertension and Pre-Eclampsia among Sudanese Women
Authors: Osman Duaa Adil , Ahmed Aimun AE. , Khairy Salah I. , Haleem Salah Eldin Abdel Hag Abdel 
Published: February 2022

Objective: The present study has been conducted with the aim of determining the clinical status of gestational hypertensive disorders in Sudan.
Methods: An analytical case-control, comparative and descriptive cross-sectional, hospital-based study was conducted at Omdurman Maternity Hospital (OMH). It included 228 cases of gestational hypertensive disorders. Data were collected through interviews, questionnaire, and admission records and analyzed statistically.
Results: The clinical status of pregnancy-induced hypertension and pre-eclampsia among Sudanese women has been estimated. Spontaneous pregnancies were 94.6% of the cases. Multigravida were 50.4% of pregnant Sudanese women presenting at OMH, 20.7% of them had a history of gestational hypertensive disorders and 18.1% had a history of miscarriage. Among the patients admitted with gestational hypertensive disorders 75% developed preeclampsia, 91% has shown non-syndromic complications and 52.2% were asymptomatic.
Conclusion: Maternal age between 18-40 years, nulliparous primigravida or multigravida with long latency period and history of miscarriage are the commonest risk factors of hypertension complication during pregnancy, including preeclampsia, in Sudan. Significantly lower serum calcium and/or higher serum magnesium are associated with preeclampsia, syndromic HELLP is a rare association. Patient awareness is critical for early detection and prevention of disease progression.
Case Report on Hypertension in Elderly Patients
Authors: Tripathi Anjali , Kasturkar Pooja , Gomase Kavita , Gawai Jaya , Uke Trupti , Khandar Jaya , Kolhekar Sonali , Tembhare Vaishali 
Published: February 2022

Introduction: The other name of high blood pressure is hypertension. Blood pressure is the force exerted by person against wall of blood vessels. Normal value of blood pressure is 120/80 mmHg. Hypertension increases with increasing in age. It can cause various health complications like stroke, heart diseases and affect psychological health and sometimes cause death.
Clinical Findings: Chest pain, not having proper sleep, headache, irregular heart beat, loss of appetite, fatigue, anxiety, lack of coping ability.
Diagnostic Evaluation: After performing various kinds of the investigations the result is Hb% - 12.9 gm%, Total RBC Count – 4.6 millions/cumm, Total WBC count – 14500 millions/cumm, Monocytes – 2%, Granulocytes – 56%, Lymphocytes – 40%. Blood pressure – 160/100.
Therapeutic Intervention: Inj. Pantroprazole 40 mg IV x OD, Inj Emset 4 mg IV x TDS, Inj. Levoflox 500 mg IV x OD, Tab Amlo 5 mg orally x OD, Tab Zincovit 5mg orally x OD, Tab. Orotex XT 10 mg orally xOD.
Outcome: After treatment there was improvement in my patients condition such as relief from Chest pain, Insomnia, irregular heartbeat, Headache. Increase in nutrition pattern and was and was able to cope up with the normal life stressors. The elevated blood pressure which was 160/100 was under the normal condition it was 120/80 mmHg.
Conclusion: My Patient was admitted in Female Medicine ward no 23, AVBRH with known case of Hypertension and she had complains of Chest pain, Headache, loss of appetite, Insomnia. After getting proper treatment her condition was improved.
Critical Review on Vrushya basti: A Therapeutic Approach
Authors: Bhisikar Gautami , Parwe Shweta , Nisargandha Milind , Tikale Swati 
Published: February 2022

Background: Vrushya chikitsa is one of the eight principal branches of the Ashtanga Ayurveda. The Rasayana and Vajikarana therapy promotes longevity and imparts the healthy individual's strength, complexion, and overall well-being. It deals with infertility and problems involving the body's vital reproductive fluids of Shukra dhatu. Vrushya chikitsa is also known as Vajikarana, which translates to "medication or therapy that allows a male to copulate with a woman." Vrushya chikitsa also aids in the nourishment of a person's physique. Vrushya chikitsa also helps in nourishing the body of the person. In six different Samhitas, including the Brihatrayee, Bhela Samhita, Vangasena Samhita and Bhavprakash Samhita, numerous Vrushya Basti are mentioned.
Aim: To study the vrushya basti in different Samhita.
Results: There is various vrushya basti mentioned in different Samhita, but some of studied practically, there is some unavailability of contents of vrushya basti. Due to some unavailability of contents like the meat of titir, peacock etc. vrushya basti is not possible to study.
Conclusion: There should have to check the efficacy for every vrushya basti to generate scientific evidence.
Adverse Drug Reactions in Terms of Dentistry
Authors: Dangara Yogita , Chabbra Kumar Gaurav 
Published: February 2022

There is a wide range of drugs and their clinical applications that can cause adverse drug reactions (ARD) due to dose, duration, age, and gender. Drugs like ACE inhibitors, which can cause xerostomia, lichen planus, which is caused by NSAIDs and anti hypertensive drugs, ulceration, pigmentation, and osteonecrosis are not only caused by bisphosphonates but also antiangiogenic agents, and malignancy is targeted by rapamycin in the oral cavity. Changes in taste sensation, angioedema, and infection are also some of the side effects of drugs that have been reported. Immunosuppressed patients show more advanced and complex lesions. A clinician shouldn look for adverse effects of medicine.
Clinical Outcome and Laboratory Parameters in Sickle Cell Anemia Patients of Pediatric Age Group Post Hydroxyurea Therapy
Authors: Gupta Nihar , Hiwale Kishore , Vagha Sunita , Bhake Arvind , Pawar Sukanya 
Published: February 2022

Background: Homozygous condition in Sickle cell disease (SCD) is called as sickle cell anemia(SCA). In sickle cell anemia patients clinically presents as hemolytic anemia, vaso-occlusive events, along with organ dysfunction and acute chest syndrome. Recently Hydroxyurea has shown promising results in treatment of sickle cell anemia. Hydroxyurea is the only approved drug by FDA which has shown disease modifying results.
Aim: To determine the clinical outcome and laboratory parameters in SCA patients of pediatric age group post-hydroxyurea therapy.
Methods: A total of 30 patients who were diagnosed as Sickle cell anemia (SCA) patients in Sickle cell anemia OPD of Pediatric department were included in the study.
Results: Hydroxyurea therapy is expected to increase HbF% levels and improve the clinical outcome and laboratory parameters in sickle cell anemia patients of pediatric age group.
Scale‐Up and Design of a Pilot‐Plant Photobioreactor for the Continuous Culture of Spirulina platensis
Authors: Vernerey A. , Albiol J. , Lasseur C. , Gòdia F. 
Published: July 2002

AbstractScale‐up of bioreactors has the intrinsic difficulty of establishing a reliable relationship among physical parameters involved in the design of the new bioreactor and the physiology of the cultured cells. This is more critical in those cases where a more complex operation of the bioreactor is needed, such as in photobioreactors. A key issue in the operation of photobioreactors is establishing a quantification for the interaction between external illumination, internal light distribution and cell growth. In this paper an approach to the scale‐up of a photobioreactor for the culture of Spirulina platensis, based on a mathematical model describing this interaction, and the operation of a previous reactor 10 times smaller is presented. The paper describes the approach followed in the scale‐up, the analysis of different design constraints, the physical realization of the new bioreactor design, innovative use of plastic material walls to improve reactor safety, and finally the corroboration of its satisfactory operation.
Electrostatic Droplet Generation for Encapsulat ion of Somatic Tissue: Assessment of High‐Voltage Power Supply
Authors: Goosen Mattheus F. A. , Al‐Ghafri Abdullah S. , Mardi Osman El , Al‐Belushi Mohammed I. J. , Al‐Hajri Hamad A. , Mahmoud Eltag S. E. , Consolacion Evangeline C. 
Published: July 2002

AbstractThe production of alginate microbeads with and without somatic tissue was investigated using an electrostatic droplet generator with a custom‐made fixed (5.7 kV) and variable (0–20 kV) high‐voltage power supply. The effects of applied potential, needle size, and alginate concentration were assessed as well as the immobilization of carnation callus cells. The high‐voltage output from the power supply depended on whether the low‐voltage input was increasing or decreasing. This hysteresis effect may be due to the electrical properties of the oscillator in the high‐voltage source. While a short electrode distance and a high needle gauge were important for producing small alginate bead diameters (e.g., 100 μm), alginate concentration in the range 1–3% (w/v) was not a key factor. Somatic tissue encapsulated using 2% sodium alginate retained viability over a 2‐month culture period.
Production of Cell‐Free Xanthan Fermentation Broth by Cell Adsorption on Fibers
Authors: Yang Shang‐Tian , Lo Yang‐Ming , Chattopadhyay Devamita 
Published: July 2002

AbstractXanthan gum is a microbial polysaccharide widely used in food and oil‐drilling industries. Xanthan gum produced from the current commercial fermentation process usually contains cells and cell debris, which lower the filterability of the xanthan solution and limit its applications. The production of cell‐free xanthan gum fermentation broth is thus desirable. The feasibility of removing cells from the xanthan fermentation broth by cell adsorption to various woven fibrous materials was studied. It was found that both cotton and polyester fibers could be used to adsorb Xanthomonas campestris cells present in the fermentation broth either during batch fermentation or after the fermentation. Almost all cells were removed from the fermentation broth by adsorption to fibers. Cotton terry cloth had rough surfaces and was the preferred material for cell adsorption. Cell adsorption to cotton was faster than to polyester fibers. The adsorption kinetics can be modeled by a first‐order rate equation. The adsorption rate constants were 30–40% higher for cotton than for polyester. Cell adsorption was not efficient in the absence of xanthan gum, suggesting that the exopolysaccharide, xanthan gum, was important for efficient cell adsorption to fibers.
Association of elevated insulin‐like growth factor binding protein‐1 with insulin resistance in hyperthyroidism
Authors: Jenkins Richard C. , Valcavi Roberto , Zini Michele , Frasoldati Andrea , Heller Simon R. , Camacho‐Hubner Cecilia , Gibson J. Martin , Westwood Melissa , Ross Richard J. M. 
Published: July 2002

OBJECTIVEInsulin‐like growth factor binding‐protein‐1 (IGFBP‐1) has a role in glucose homeostasis and is present at high concentrations in hyperthyroidism. We have investigated the relationship between IGFBP‐1 concentration and glucose homeostasis in hyperthyroidism.DESIGNPatients and controls had intravenous glucose tolerance tests (IVGTT) and/or oral glucose tolerance tests (OGTT). Patients were tested when hyperthyroid and when euthyroid whilst the controls were tested once. The IVGTT was used to assess insulin sensitivity and the OGTT to establish that the study group had abnormal glucose tolerance. The hyperthyroid patients were treated with methimazole to restore euthyroidism.PATIENTSTen patients (9 females) and 13 healthy controls (9 females) consented to the study. Ten patients and nine controls (7 females) had IVGTT. Six patients (5 females) and six controls (4 females) had OGTT.MEASUREMENTSGlucose, insulin, glucagon, GH and IGFBP‐1 were measured during GTT. IGF‐I, free thyroid hormones, and TSH concentrations were measured basally.RESULTSHyperthyroid subjects were insulin resistant and 67% had impaired glucose tolerance. Fasting IGFBP‐1 levels were doubled in hyperthyroid subjects compared to healthy controls and correlated positively with free T4 (r = 0.84, P < 0.0001), with peak glucose during the OGTT (r = 0.68, P < 0.005) with peak insulin during the IVGTT (r = 0.51, P < 0.005) and negatively with glucose disappearance constant (r = − 0.52, P < 0.005). IGFBP‐1 was highly phosphorylated in hyperthyroid and control subjects. Fasting insulin and IGFBP‐1 levels were unrelated but IGFBP‐1 suppressed acutely during GTT in all groups. GH levels fell less in patients with hyperthyroidism than in normals during GTTs.CONCLUSIONSWe conclude that in hyperthyroidism thyroid hormones directly increase fasting IGFBP‐1 concentration but acute regulation of IGFBP‐1 by insulin is normal and that elevated fasting phosphorylated IGFBP‐1 concentration is associated with insulin resistance.
Behavioural and cognitive associations of short stature at 5 years
Authors: Stathis SL , O’Callaghan MJ , Williams GM , Najman JM , Andersen MJ , Bor W 
Published: July 2002

Objectives:To determine the extent to which childhood short stature is associated with cognitive, behavioural and chronic health problems, and whether these problems could be attributed to recognized adverse biological, psychosocial or psychological factors.Methodology:At their first antenatal session, 8556 women were enrolled in a prospective study of pregnancy. When their children were 4 and 6 years of age, mothers completed a detailed questionnaire concerning their child’s health and behaviour. A Peabody Picture Vocabulary Test–Revised (PPVT‐R) was completed by the child at 5 years of age. Z scores were used to categorize height measurements in 3986 children. The relationship of these height categories with the child’s health, and behavioural and cognitive problems was then examined.Results:No association was found between height and symptoms of chronic disease or behaviour problems in boys or girls. On the unadjusted analysis, mean PPVT‐R scores were significantly lower in boys with heights < 3 percentile and 3–< 10 percentile compared with study children between 10 to 90 percentile (P< 0.01). Scores were similarly significantly lower in girls with heights < 3 percentile and 3–10 percentile (P= 0.01). Even after adjusting for psychosocial and biological confounders, short stature remained a significant predictor for lower PPVT‐R scores in both boys and girls, although height only accounted for 1.1% of the variance in scores in boys and 0.5% of the variance in PPVT‐R scores in girls. Psychosocial factors had a greater role than height in determining PPVT‐R scores at 5 years of age.Conclusions:These findings suggest a significant, though small, association between height and PPVT‐R scores at 5 years of age, independent of psychosocial disadvantage and known biological risk factors.
Gate pulse frequency-dependent kink effects in GaAs metal-semiconductor field-effect-transistors with a low-temperature-grown buffer layer
Authors: Haruyama Junzi , Negishi Hitoshi 
Published: July 2002

Two kinds of kink effects (abrupt increases in pulsed drain current ID) were observed in GaAs metal–semiconductor field-effect transistors (MESFETs) with a buffer layer grown by molecular-beam epitaxy at low substrate temperature of 300 °C (LTB), when pulsed voltage trains with swinging range from threshold voltage to 0 V and 10% duty cycle were applied to gate electrode. These kink effects were not observed in dc measurement; however, they appeared with increasing frequency of those gate pulse trains. One kink effect is observed at 100 μs of the pulse width of high level Wh with the pulsed ID increase of 11% (first kink). Overshoot observed in the transient wave form suggests that this first kink effect is attributed only to capture of excess number of holes, which are generated by impact ionization along channel, into the hole trap of LTB. The lifetime of these holes is estimated to be 100 μs at least in the LTB from the discussion. The other kink effect is observed at 10 μs of Wh with the pulsed ID increase of 47% (second kink). This second kink effect is attributed to elimination of anomalous transient response of self-side-gating effect (SSGE) (side-gating effect caused by negative voltage applied to gate pad) by excess holes mentioned above.
The mechanism of this transient of SSGE is discussed based on the observation of anomalous transient wave-form change with as small a time constant as 200 ns, using the model of side-gating effect proposed by Goto, Ohno, and Yano [IEEE Trans. Electron Devices ED-34, 1821 (1990)]. The lifetime of holes is estimated to be 10 μs at least in VD region smaller than the VD at which impact ionization occurs from the discussion. The observation of these kink effects gives evidence that the elimination of kink effects in dc was due to perfect recombination of free holes in all VD regions in this LTB MESFET. On the other hand, pulsed ID–VD curves were the same as ID–VD measured at 0 V of Vg in dc of the MESFETs with an i-GaAs buffer layer grown at 600 °C. Therefore, it is concluded that these frequency-dependent kink effects result only from the LTB. All kink effects are eliminated in dc measurement of this LTB MESFET. The kink effect related to SSGE, however, is observed at higher frequency in the LTB MESFET rather than in the MESFET with normal temperature grown buffer.
Magnetic properties of 3%Si-Fe thin sheets annealed in Ar atmosphere (abstract)
Authors: Yamashiro Y. , Yonesu A. , Hashi S. , Ishiyama K. , Arai K. I. 
Published: July 2002

It has been actually required in recent years to decrease iron losses in transformer cores, as increment of electric energy consumption in all industries and homes. Answering to such requirements, Arai et al. developed a new type magnetic core material; it was tertiary recrystallized Si steel with 50 μm thickness, and it was of as low iron loss as an amorphous materials one. The Si steel was made by an annealing in a vacuum of 1×10−3 Pa and at a temperature of 1200 °C. In this study, we prepared samples for measurements from (110)[001] grain-oriented 3%Si steel with 300 μm thickness. We coldrolled them to about 50 μm using a four-high rolling mill, and then annealed in an atmosphere of highly pure Ar gas, from a point of view of saving energy. We investigated effects of annealing time, heating rate and gas flow rate on magnetic properties. The annealing temperature was fixed at 1000 °C. Hysteresis loops were drawn with single-sheet tester. Grain structure and its direction were decided by etch pit method. Coercive force Hc and induction B8 which is the induction at 800 A/m applied field were obtained from the hysteresis loops. The magnetic properties were somewhat changed according to the annealing condition. The coercive force varied from 5 to 30 A/m, and the induction varied from 1.45 to 1.85 T. The best properties, Hc was 5 A/m and B8 was 1.85 T, were obtained under the annealing condition; annealing time was 60 min, heating rate was 3 °C/s, and gas flow rate was 2 ι/min.
The surfaces of the samples were not covered with tertiary recrystalline, but wholly with secondary recrystalline. About 90% grains were (110) plane, the rest was (100) plane. And about 90% [001] axes oriented to the rolling direction within five degree misorientation.