bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Facilities Management (SFM) initiatives in Malaysia hotel industry: reliability and validity analysis using Smart-PLS
Authors: Abu Talib Alyaa Afifah , Muhamad Ariff Nor Rima , Hasim Mohamad Sufian , Hanafiah Mohd Hafiz 
Published: October 2022

Abstract
This paper presents the reliability and validity analysis of the data collection instrument used in a larger study scale. A pilot study has been employed to prove the viability of the questionnaire survey and make improvements prior to the actual survey examining the framework of Sustainable Facilities Management (SFM) initiatives for Malaysia’s hotel industry. A survey was conducted among 5-star hotels registered under the Ministry of Tourism, Arts and Culture (MOTAC) Malaysia. A total of 34 respondents were successfully recruited from Klang Valley’s hotel staff. The reliability and validity analyses of this pilot study were conducted using PLS-SEM: SMART-PLS Version 3.3.2. The study’s findings revealed that the surveyed SFM initiatives in the hotel organisations were statistically significant. In addition, the findings indicated that the SFM initiatives positively contributed towards sustainable development goals (SDG); particularly SDG 6, SDG 7, SDG 9, SDG 12, and SDG 13. The study’s main implications further confirmed that the instrument used in the pilot study fulfilled the acceptable requirements of the reliability and validity range for the main data collection purpose of the intended study.
Degradation of sulfamethoxazole in water by dielectric barrier discharge plasma jet: influencing parameters, degradation pathway, toxicity evaluation
Authors: HU Shuheng , YAN Weiwen , YU Jinming , ZHU Bin , LAN Yan , XI Wenhao , XU Zimu , HAN Wei , CHENG Cheng 
Published: October 2022

Abstract
Sulfamethoxazole (SMX) is an antibiotic and widely present in aquatic environments, so it presents a serious threat to human health and sustainable development. A dielectric barrier discharge (DBD) plasma jet was utilized to degrade aqueous SMX, and the effects of various operating parameters (working gas, discharge power, etc) on SMX degradation performance were studied. The experimental results showed that the DBD plasma jet can obtain a relatively high degradation efficiency for SMX when the discharge power is high with an oxygen atmosphere, the initial concentration of SMX is low, and the aqueous solution is under acidic conditions. The reactive species produced in the liquid phase were detected, and OH radicals and O3 were found to play a significant role in the degradation of SMX. Moreover, the process of SMX degradation could be better fitted by the quasi-first-order reaction kinetic equation. The analysis of the SMX degradation process indicated that SMX was gradually decomposed and 4-amino benzene sulfonic acid, benzene sulfonamide, 4-nitro SMX, and phenylsulfinyl acid were detected, and thus three possible degradation pathways were finally proposed. The mineralization degree of SMX reached 90.04% after plasma treatment for 20 min, and the toxicity of the solution fluctuated with the discharge time but eventually decreased.
First report on onsite temperature based recovery of quenched chemiluminescence signal from graphenized μPADs: validation by catechins radical scavenging
Authors: Kumar Pavar Sai , Advincula Paul A , Goel Sanket 
Published: October 2022

Abstract
Graphene-based materials are excellent acceptors of the CRET phenomenon. Due to the presence of

π

-conjugated planar structure, these materials were reported to quench the chemiluminescence (CL) signal. Based on this fact, herein, for the first time, the recovery of quenched CL signal from different graphene-based materials is successfully obtained through the catalytic activity of onsite temperature. The maximum recovery of a quenched signal at an optimum temperature of 70

∘

C

was 1440% from the 10 mg ml−1 reduced graphene oxide paper analytical devices. The recovery of flash graphene and laser induced graphene materials were found to be 895% and 521%, respectively, for the same conditions via the generation of

π

-conjugated carbon radicals. Catechin, an antioxidant, was analyzed from 0.1 nM to 500 nM to interpret the generation of carbon radicals from graphenized materials. The proposed smartphone-enabled onsite heating recovery model was validated with the lower limit of 94 pM (27.3 pg ml−1) of catechin concentration without advanced photodiodes or instrumentation. The validation was performed in real samples of green tea (1 and 2). This method of CL recovery can be a future model for indicating the purity of graphene-based materials without using advanced instrumentations.
Uniform Lech’s inequality
Authors: Ma Linquan , Smirnov Ilya 
Published: October 2022

Let

(
R
,

m

)

(R,\mathfrak {m})

be a Noetherian local ring of dimension

d
≥
2

d\geq 2

. We prove that if

e
(

R
^

r
e
d

)
>
1

e(\widehat {R}_{red})>1

, then the classical Lech’s inequality can be improved uniformly for all

m

\mathfrak {m}

-primary ideals, that is, there exists

ε
>
0

\varepsilon >0

such that

e
(
I
)
≤
d
!
(
e
(
R
)
−
ε
)
ℓ
(
R

/

I
)

e(I)\leq d!(e(R)-\varepsilon )\ell (R/I)

for all

m

\mathfrak {m}

-primary ideals

I
⊆
R

I\subseteq R

. This answers a question raised by Huneke, Ma, Quy, and Smirnov [Adv. Math. 372 (2020), pp. 107296, 33]. We also obtain partial results towards improvements of Lech’s inequality when we fix the number of generators of

I
I

.
EV charging station with cascaded low-pass filtering scheme-based control of unified power quality conditioner
Authors: Patel Arpitkumar J , Sant Amit V 
Published: October 2022

Abstract
This paper proposes a cascaded low-pass filter (CLPF) scheme for the control of a unified power quality conditioner (UPQC) installed for enhancing the power quality of an electric vehicle (EV) charging station. With the incorporation of UPQC, the EV charging station draws sinusoidal currents at unity power factor and the supply voltage is maintained at the nominal value at the charger input. In the CLPF scheme, the α–β components of the load current are individually processed through a cascade connection of two LPFs to determine the corresponding fundamental orthogonal components. Based on thus determined components, the instantaneous and peak value and phase angle of the fundamental positive sequence component (FPSC) of the load current are computed. Similarly, the corresponding quantities related to the load and supply voltages are also computed with the CLPF scheme. With the computations related to the load current and supply voltage, the unit voltage templates (UVTs), power factor and fundamental active component (FAC) of the load current are calculated. For the control of shunt compensation, reference currents are generated based on the FAC of the load current and UVTs. Alternately, the control of series compensation is employed with the help of UVTs and peak amplitude of the FPSC of the load voltage. The performance of CLPF scheme-based extraction is compared with that of the earlier reported schemes through simulation and experimental studies. The performance comparison reveals a faster dynamic and more accurate steady-state response with the proposed scheme. The performance analysis of the proposed CLPF scheme-based control of a UPQC deployed at the EV charging station for different operating conditions demonstrates station operation with requisite reactive power compensation and mitigation of voltage sag/swell, and prevention of propagation of harmonic and unbalanced currents into the grid. This results in increased reliability of charger operation, energy savings and increased efficiency of the distribution network.
Monitoring the acute and subacute recovery of cognitive ocular motor changes after a sports-related concussion
Authors: Symons Georgia F , O’Brien William T , Abel Larry , Chen Zhibin , Costello Daniel M , O’Brien Terence J , Kolbe Scott , Fielding Joanne , Shultz Sandy R , Clough Meaghan 
Published: October 2022

AbstractIdentifying when recovery from a sports-related concussion (SRC) has occurred remains a challenge in clinical practice. This study investigated the utility of ocular motor (OM) assessment to monitor recovery post-SRC between sexes and compared to common clinical measures. From 139 preseason baseline assessments (i.e. before they sustained an SRC), 18 (12 males, 6 females) consequent SRCs were sustained and the longitudinal follow-ups were collected at 2, 6, and 13 days post-SRC. Participants completed visually guided, antisaccade (AS), and memory-guided saccade tasks requiring a saccade toward, away from, and to a remembered target, respectively. Changes in latency (processing speed), visual–spatial accuracy, and errors were measured. Clinical measures included The Sports Concussion Assessment Tool, King-Devick test, Stroop task, and Digit span. AS latency was significantly longer at 2 days and returned to baseline by 13-days post-SRC in females only (P &lt; 0.001). Symptom numbers recovered from 2 to 6 days and 13 days (P &lt; 0.05). Persistently poorer AS visual–spatial accuracy was identified at 2, 6 and 13 days post-SRC (P &lt; 0.05) in both males and females but with differing trajectories. Clinical measures demonstrated consistent improvement reminiscent of practice effects. OM saccade assessment may have improved utility in tracking recovery compared to conventional measures and between sexes.
Recurrence of Symptoms Following Cryptococcal Meningitis: Characterizing a Diagnostic Conundrum With Multiple Etiologies
Authors: Bahr Nathan C , Skipper Caleb P , Huppler-Hullsiek Kathy , Ssebambulidde Kenneth , Morawski Bozena M , Engen Nicole W , Nuwagira Edwin , Quinn Carson M , Ramachandran Prashanth S , Evans Emily E , Lofgren Sarah M , Abassi Mahsa , Muzoora Conrad , Wilson Michael R , Meya David B , Rhein Joshua , Boulware David R 
Published: October 2022

Abstract

Background
Cryptococcal meningitis is a common cause of AIDS-related mortality. Although symptom recurrence after initial treatment is common, the etiology is often difficult to decipher. We sought to summarize characteristics, etiologies, and outcomes among persons with second-episode symptomatic recurrence.

Methods
We prospectively enrolled Ugandans with cryptococcal meningitis and obtained patient characteristics, antiretroviral therapy (ART) and cryptococcosis histories, clinical outcomes, and cerebrospinal fluid (CSF) analysis results. We independently adjudicated cases of second-episode meningitis to categorize patients as (1) microbiological relapse, (2) paradoxical immune reconstitution inflammatory syndrome (IRIS), (3) persistent elevated intracranial pressure (ICP) only, or (4) persistent symptoms only, along with controls of primary cryptococcal meningitis. We compared groups with chi-square or Kruskal-Wallis tests as appropriate.

Results
724 participants were included (n = 607 primary episode, 81 relapse, 28 paradoxical IRIS, 2 persistently elevated ICP, 6 persistent symptoms). Participants with culture-positive relapse had lower CD4 (25 cells/μL; IQR: 9–76) and lower CSF white blood cell (WBC; 4 cells/μL; IQR: 4–85) counts than paradoxical IRIS (CD4: 78 cells/μL; IQR: 47–142; WBC: 45 cells/μL; IQR: 8–128). Among those with CSF WBC &lt;5 cells/μL, 86% (43/50) had relapse. Among those with CD4 counts &lt;50 cells/μL, 91% (39/43) had relapse. Eighteen-week mortality (from current symptom onset) was 47% among first episodes of cryptococcal meningitis, 31% in culture-positive relapses, and 14% in paradoxical IRIS.

Conclusions
Poor immune reconstitution was noted more often in relapse than IRIS as evidenced by lower CSF WBC and blood CD4 counts. These easily obtained laboratory values should prompt initiation of antifungal treatment while awaiting culture results.

Clinical Trials Registration
NCT01802385.
Diagnostic Performance of Physician Gestalt for Bacteremia in Patients in the Process of Being Admitted With Suspected Infection
Authors: Fujii Kotaro , Takada Toshihiko , Kamitani Tsukasa , Aoki Takuya , Takeshima Taro , Kudo Masataka , Sasaki Sho , Yano Tetsuhiro , Yagi Yu , Tsuchido Yasuhiro , Itoh Hideyuki , Fukuhara Shunichi , Yamamoto Yosuke 
Published: October 2022

AbstractBackgroundDue to potentially fatal consequences of missed bacteremia, blood cultures are often overused. While there are several prediction models that can be used to identify patients who truly need blood cultures, physicians often rely on their gestalt. We evaluated the diagnostic performance of physician gestalt for bacteremia in comparison with 2 existing prediction models: Takeshima and Shapiro.MethodsThe study enrolled consecutive adult patients with suspected infection who were in the process of being admitted to the general medicine department at 2 hospitals between April 2017 and January 2019. Attending physicians provided gestalt regarding risk of bacteremia (0%–100%). Patients with a &lt;10% risk estimated via each strategy (ie, physician gestalt or 2 existing models) were categorized as bacteremia excluded (ie, blood cultures were considered unnecessary). Strategies were compared in terms of safety (proportion of patients with bacteremia among those classified as bacteremia excluded) and efficiency (proportion of patients classified as bacteremia excluded among the total cohort).ResultsAmong 2014 patients, 292 (14.5%) were diagnosed with bacteremia. The safety of physician gestalt and the Takeshima and Shapiro models was 3.7% (95% confidence interval [CI], 2.2% to 5.7%), 6.5% (95% CI, 5.0% to 7.9%), and 10.8% (95% CI, 9.4% to 12.3%), whereas the efficiency of each strategy was 22.4% (95% CI, 22.5% to 26.3%), 52.7% (95% CI, 50.5% to 54.9%), and 87.8% (95% CI, 86.3% to 89.2%), respectively.ConclusionsPhysician gestalt was safer but less efficient than existing models. Clinical prediction models could help reduce the overuse of blood cultures.
Assembly-free discovery of human novel sequences using long reads
Authors: Li Qiuhui , Yan Bin , Lam Tak-Wah , Luo Ruibang 
Published: October 2022

Abstract
DNA sequences that are absent in the human reference genome are classified as novel sequences. The discovery of these missed sequences is crucial for exploring the genomic diversity of populations and understanding the genetic basis of human diseases. However, various DNA lengths of reads generated from different sequencing technologies can significantly affect the results of novel sequences. In this work, we designed an assembly-free novel sequence (AF-NS) approach to identify novel sequences from Oxford Nanopore Technology long reads. Among the newly detected sequences using AF-NS, more than 95% were omitted from those using long-read assemblers and 85% were not present in short reads of Illumina. We identified the common novel sequences among all the samples and revealed their association with the binding motifs of transcription factors. Regarding the placements of the novel sequences, we found about 70% enriched in repeat regions and generated 430 for one specific subpopulation that might be related to their evolution. Our study demonstrates the advance of the assembly-free approach to capture more novel sequences over other assembler based methods. Combining the long-read data with powerful analytical methods can be a robust way to improve the completeness of novel sequences.
Vigorous physical activity, incident heart disease, and cancer: how little is enough?
Authors: Ahmadi Matthew N , Clare Philip J , Katzmarzyk Peter T , del Pozo Cruz Borja , Lee I Min , Stamatakis Emmanuel 
Published: October 2022

AbstractAimsVigorous physical activity (VPA) is a time-efficient way to achieve recommended physical activity levels. There is a very limited understanding of the minimal and optimal amounts of vigorous physical activity in relation to mortality and disease incidence.Methods and resultsA prospective study in 71 893 adults [median age (IQR): 62.5 years (55.3, 67.7); 55.9% female] from the UK Biobank cohort with wrist-worn accelerometry. VPA volume (min/week) and frequency of short VPA bouts (≤2 min) were measured. The dose–response associations of VPA volume and frequency with mortality [all-cause, cardiovascular disease (CVD) and cancer], and CVD and cancer incidence were examined after excluding events occurring in the first year. During a mean post-landmark point follow-up of 5.9 years (SD ± 0.8), the adjusted 5-year absolute mortality risk was 4.17% (95% confidence interval: 3.19%, 5.13%) for no VPA, 2.12% (1.81%, 2.44%) for &gt;0 to &lt;10 min, 1.78% (1.53%, 2.03%) for 10 to &lt;30 min, 1.47% (1.21%, 1.73%) for 30 to &lt;60 min, and 1.10% (0.84%, 1.36%) for ≥60 min. The ‘optimal dose’ (nadir of the curve) was 53.6 (50.5, 56.7) min/week [hazard ratio (HR): 0.64 (0.54, 0.77)] relative to the 5th percentile reference (2.2 min/week). There was an inverse linear dose-response association of VPA with CVD mortality. The ‘minimal’ volume dose (50% of the optimal dose) was ∼15 (14.3, 16.3) min/week for all-cause [HR: 0.82 (0.75, 0.89)] and cancer [HR: 0.84 (0.74, 0.95)] mortality, and 19.2 (16.5, 21.9) min/week [HR: 0.60 (0.50, 0.72)] for CVD mortality. These associations were consistent for CVD and cancer incidence. There was an inverse linear association between VPA frequency and CVD mortality. 27 (24, 30) bouts/week was associated with the lowest all-cause mortality [HR: 0.73 (0.62, 0.87)].ConclusionVPA of 15–20 min/week were associated with a 16–40% lower mortality HR, with further decreases up to 50–57 min/week. These findings suggest reduced health risks may be attainable through relatively modest amounts of VPA accrued in short bouts across the week.
Using a Collective Impact framework to evaluate an Australian health alliance for improving health outcomes
Authors: Parkinson Joy , Hannan Thomas , McDonald Nicole , Moriarty Stephanie , Nguyen Mai , Ball Lauren 
Published: October 2022

Summary
Complex social issues such as population health mean that no one person, organization or sector can resolve these problems alone and instead require a collaborative approach. This study applied the Collective Impact framework to evaluate the alliance responsible for delivering a large-scale health promotion initiative. Committee meeting minutes for a 4-year period and qualitative interviews with key stakeholders (N = 14) involved in the design and implementation of the initiative explored the factors that contributed to collaborative efforts and initiative outcomes. Major strengths of the Healthier Queensland Alliance (the Alliance) stemmed from identifying a common agenda and using frequent communication to develop trust among Alliance partners. These processes were important, particularly in improving key relationships to ensure inclusivity and equity. Reinforcing activities helped to support individual organizational efforts, while shared measurement systems promoted data-driven decision-making and learning, which contributed to continuous improvement and innovation. Current findings support the use of the Collective Impact framework as a scaffold to assist collaborative alliances in working effectively and efficiently when implementing large-scale initiatives aiming to create positive social impact. This study has identified the foundations of practice to establish a successful Collective Impact alliance.
Customary International Law as a Source of Individual Criminal Responsibility
Authors: Staiano Fulvia 
Published: October 2022

Abstract
In the Abd-Al-Rahman judgment of 1 November 2021, the Appeals Chamber of the International Criminal Court (ICC) was asked to rule on the compatibility of the ICC’s exercise of jurisdiction over the accused with the principle of nullum crimen sine lege. The question was motivated by the fact that the alleged crimes had neither been committed on a state party’s territory nor by a national of a state party. This article focuses on the answer provided by the Appeals Chamber and on the issues raised by its judicial reasoning. First, it discusses the legal sources to be applied in the context of criminal proceedings before the ICC with respect to situations not involving states parties to the Rome Statute. Second, it reflects on whether and to what extent customary international law may be referred to as the main source of individual criminal responsibility in such proceedings without infringing the principle of nullum crimen sine lege. In this respect, the article also analyses the accessibility and foreseeability test with specific reference to customary norms.
Observational study to predict the efficacy and optimal duration of nivolumab treatment in patients with previously treated advanced or recurrent non-small cell lung cancer
Authors: Goto Yasushi , Yoh Kiyotaka , Kato Terufumi , Hosomi Yukio , Usui Kazuhiro , Fukui Tomoya , Hirano Katsuya , Tanaka Hiroshi , Taguri Masataka , Kunitoh Hideo 
Published: October 2022

Abstract

Background
Immune checkpoint inhibitors, including nivolumab, are essential agents for treating non-small cell lung cancer. However, predictive markers are currently lacking, especially using factors based on patient-reported outcomes.

Methods
We conducted a prospective observational study of 244 patients with advanced or recurrent non-small cell lung cancer treated with second- or later-line nivolumab from August 2016 to December 2017. Patient-reported outcomes, including quality of life, were evaluated by the EQ-5D-5L before and during nivolumab treatment. To predict the efficacy of nivolumab during the early treatment phase, we also analyzed the patients’ clinical characteristics, responses and immune-related adverse events at 9 weeks of therapy. The primary endpoint was the disease control rate at 25 weeks after the initiation of nivolumab.

Results
The objective response and disease control rates at 25 weeks were 18.5 and 41.2%, respectively. The emergence of immune-related adverse events at 9 weeks did not significantly affect the disease control rate at 6 months. The response at 9 weeks and patient-reported quality of life were potentially predictive of disease control at week 25. Disease control on week 9 and patients-reported outcomes were potential predictive factors for the overall survival.

Conclusions
This study found no new baseline factors predicting the outcome of nivolumab treatment in patients with non-small cell lung cancer, but response to nivolumab was a robust predictor of overall efficacy. In addition, patient-perceived quality of life could predict the durable efficacy of immune checkpoint inhibitors.