bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curative Cell and Gene Therapy for Osteogenesis Imperfecta
Authors: Schindeler Aaron , Lee Lucinda R , O'Donohue Alexandra K , Ginn Samantha L , Munns Craig F 
Published: March 2022

ABSTRACT
Osteogenesis imperfecta (OI) describes a series of genetic bone fragility disorders that can have a substantive impact on patient quality of life. The multidisciplinary approach to management of children and adults with OI primarily involves the administration of antiresorptive medication, allied health (physiotherapy and occupational therapy), and orthopedic surgery. However, advances in gene editing technology and gene therapy vectors bring with them the promise of gene-targeted interventions to provide an enduring or perhaps permanent cure for OI. This review describes emergent technologies for cell- and gene-targeted therapies, major hurdles to their implementation, and the prospects of their future success with a focus on bone disorders. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Counselors’ attitudes toward psychedelics and their use in therapy
Authors: Hearn Benjamin G. , Brubaker Michael D. , Richardson George 
Published: March 2022

AbstractThe ‘‘psychedelic renaissance’’ is generating new evidence for psychedelics’ potential to treat numerous mental and substance use disorders. In particular, the United States Food and Drug Administration is poised to approve psychedelic drugs 3,4 methylenedioxymethamphetamine (MDMA) and psilocybin for the use in psychedelic‐assisted therapy (PAT). This renaissance has led to substantial public attention toward psychedelics, state and local changes to the legal status of psychedelics, and recent increases in the rate of psychedelic use among United States adults. Despite these advancements, the counseling profession has remained relatively disengaged from the research and general discourse surrounding psychedelics and PAT. In response to this gap, this study presents the results of a survey of counseling professionals’ attitudes toward psychedelics and PATs. Results suggest counselors’ attitudes toward psychedelic use and PATs are mixed, unless they are medically supervised. Furthermore, most counselors see potential in PAT and the need for additional research.
The impact of interprofessional communication through ICT on health outcomes of older adults receiving home care in Japan – A retrospective cohort study
Authors: Yoshimoto Takeru , Nawa Nobutoshi , Uemura Munenori , Sakano Teppei , Fujiwara Takeo 
Published: March 2022

AbstractBackgroundInformation communication technology (ICT) is crucial to modern communication and information sharing. Effective interprofessional collaboration is essential in the care of elderly people. However, little is known about the effects of ICT on care provision for elderly people in a home setting. This retrospective cohort study examines the impact of interprofessional collaboration using ICT on the health outcomes of elderly home care patients.MethodsThe Team® mobile application promotes cooperation in local medical health care. It enables providers to obtain and share patient information within a single, cloud‐based platform. We collected and analyzed data from 554 patients from Nagaoka (Niigata prefecture, Japan) who received home care services from 2015 to 2020. We calculated the cumulative hazard ratio (HR) of death or admission to a hospital or nursing home for patients whose information was shared among different professions using the platform, and for those whose information was not shared. We used a Cox proportional hazards model, adjusted for covariates, and applied propensity score matching.ResultsThe average age of the study population was 83.5 years; the median follow‐up period was 579.0 days. The risk of death or admission to a hospital or nursing home significantly decreased in the information‐shared group, compared with the control group (adjusted HR: 0.47 [p < 0.01]). Significance remained after propensity score matching (HR: 0.58; p = 0.01).ConclusionsInterprofessional collaboration using ICT may reduce the risk of death or admission to a hospital or nursing home among elderly home care patients in Japan.
Conversion surgery after preoperative therapy for advanced hepatocellular carcinoma in the era of molecular targeted therapy and immune checkpoint inhibitors
Authors: Arita Junichi , Ichida Akihiko , Nagata Rihito , Mihara Yuichiro , Kawaguchi Yoshikuni , Ishizawa Takeaki , Akamatsu Nobuhisa , Kaneko Junichi , Hasegawa Kiyoshi 
Published: March 2022

AbstractBackgroundOptimal strategies for advanced hepatocellular carcinoma (HCC) tumors, such as those with vascular tumor thrombus and those with extrahepatic metastases are unclear.MethodsA literature review was conducted focusing on conversion surgery for HCC after molecular targeted therapy and therapy using immune checkpoint inhibitors.ResultsUpfront surgical resection of advanced HCC tumors has been challenged at some institutions because of lack of promising therapeutic options. Preoperative transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy, and radiotherapy in patients with unresectable HCC were developed to improve long‐term outcome, but the results were not promising. Nonetheless, the recent advent of molecular targeted therapies and immune check‐point inhibitors, enabling frequent tumor responses, has accelerated the use of conversion surgery after these therapies in patients with initially unresectable HCC. Increasing numbers of conversion surgeries after lenvatinib therapy has been reported, and the first prospective clinical trial assessing conversion surgery after lenvatinib therapy in initially unresectable HCC has been commenced. Furthermore, the superiority of combination therapy using atezolizumab and bevacizumab over sorafenib, a conventional first‐line drug for unresectable HCC, in terms of overall survival and tumor response has been demonstrated, and the use of this regimen alongside conversion surgery is expected in addition to lenvatinib.ConclusionThe literature demonstrated the feasibility of conversion surgery after systemic therapy. Further clinical investigation of surgery after systemic therapy for advanced HCC may be undertaken by clearly distinguishing the tumor status as technically unresectable or oncologically unresectable but technically resectable.
A phenomenological analysis of invisibility syndrome in formerly incarcerated Black men
Authors: Wright Dallas , Tovar‐Murray Darrick , Noel Thomas , Chennault Ronald 
Published: March 2022

AbstractQualitative research was conducted with eight formerly incarcerated Black men on their experiences with what counseling scholar Anderson Franklin has dubbed “invisibility syndrome.” Invisibility syndrome is “an inner struggle with the feeling that one's talents, abilities, personality, and worth are not valued or even recognized because of prejudice and racism.” Results found five superordinate themes, including painfulness of invisibility, pervasiveness of invisibility, awareness of power relations, coping with invisibility, and importance of healing. Implications for counseling formerly incarcerated Black men are provided.
Metabolomic analysis reveals the influence of IC50 vitamin D3 on RAW264.7 cells based on 1H NMR and UPLC‐MS/MS
Authors: Song Xiao , Wang Yali , Wang Jun , Su Shufang , Zhu Jianhua , Geng Yue 
Published: March 2022

AbstractBACKGROUNDAs a lipid‐soluble vitamin necessary for normal human physiology, vitamin D is mostly used in fortified foods, medicines and adjuvant treatment of diseases. However, taken in high doses, vitamin D can be toxic.MethodsWe treated RAW264.7 cells with a semi‐inhibitory concentration (IC50) of vitamin D3. The metabolic changes in the treated cells were analyzed by 1H nuclear magnetic resonance (NMR) and ultra performance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS).RESULTSAfter treatment of RAW264.7 cells with an IC50 dose of 55 μm vitamin D3, tunor necrosis factor‐α levels decreased significantly and remarkable metabolic differences were also observed, with 12 types of metabolites were identified by 1H NMR and 87 identified by UPLC‐MS/MS. Moreover, the metabolism of amino acids, sugars, lipids and other metabolic pathways were also affected.CONCLUSIONAlthough vitamin D3 is an indispensable nutrient in the body, excessive exposure has negative effects on cells and their metabolism. The present study will assist further analyses of the mechanism underlying vitamin D3 toxicity. © 2022 Society of Chemical Industry.
Effects of applied voltage on the morphology and phases of electrospun poly(vinylidene difluoride) nanofibers
Authors: Nugraha Aditya Sukma , Chou Chen Chia , Yu Pin Hsun , Lin Kun‐Lin 
Published: March 2022

AbstractElectrospinning is a simple and flexible process in continuous fiber fabrication. We investigate the effect of applied voltage on morphology and phases of poly(vinylidene difluoride) nanofibers obtained using the electrospinning technique. Quantitative and qualitative analyses were performed employing multiple characterizations such as Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD) and high‐resolution transmission electron microscopy (HRTEM). The fiber diameter, affected by the spinning jet's deformation, has non‐uniform distribution at low voltages (10–16 kV) and is uniform at higher voltages (20 kV). Fiber uniformity developed due to the increased tension, which shrank the Taylor cone. The highest electroactive fraction () of phases was obtained for the smallest diameter fiber with an average diameter of 110 nm at an applied voltage of 20 kV. FTIR spectroscopy and XRD results indicate that the electric field raises the amount of phase to 74% at the present working parameters. HRTEM analysis revealed that the crystallites are very small, with α‐phase showing a size of around 10 nm and β‐phase is only of nanometric scale. Results also show that the c‐axis of α‐phase crystallites had a preferred orientation along the fiber axis. On the other hand, the c‐axis of β‐phase had a preferred orientation perpendicular to the fiber axis, implying that the direction of crystal growth for the α‐phase and β‐phase was different. © 2022 Society of Industrial Chemistry.
Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice
Authors: Nagao Michiru , Tajima Masataka , Sugiyama Erika , Shinouchi Ryosuke , Shibata Keita , Yoshikawa Masayuki , Yamamoto Takushi , Sato Vilasinee Hirunpanich , Nobe Koji , Sato Hitoshi 
Published: March 2022

AbstractIn clinical practice, pregabalin is orally administered for neuropathic pain, but causes severe central nervous system side effects, such as dizziness, which results in dose limitation or discontinuation. To reduce the central side effects of pregabalin, we developed four pregabalin preparations for transdermal application: 0.4% aqueous solution, pluronic lecithin organogel (PLO gel), hydrophilic cream, and lipophilic cream. Transdermal permeabilities of pregabalin among the four formulations were compared in vitro using hairless mouse skin. The longitudinal distribution of pregabalin within the skin was analyzed using mass spectrometric (MS) imaging. Furthermore, the in vivo analgesic effects of the formulations were evaluated using the von Frey filament test in a mouse model of diabetic neuropathy (DN). The PLO gel showed the highest permeability of pregabalin, followed by the aqueous solution, and no permeation was observed in the two cream formulations. The MS imaging analysis showed that pregabalin was distributed up to the dermis in the PLO gel 1 h after application, while the aqueous solution was distributed near the epidermis. A significant analgesic effect (p < .05) was observed 1.5 h after PLO gel application in the DN model mice, but the aqueous solution had no effect. This study indicated for the first time that pregabalin penetrated beyond the skin epidermis up to the dermis, from the PLO gel formulation, and that the application of this formulation exhibited an in vivo analgesic effect in the mouse model of DN.
Vegetation detection based on spectral information and development of a low‐cost vegetation sensor for selective spraying
Authors: Wang Aichen , Li Wei , Men Xiaohai , Gao Binjie , Xu Yifei , Wei Xinhua 
Published: March 2022

AbstractBACKGROUNDReal‐time site‐specific selective spraying for crop protection against weeds, pests and diseases requires fast and precise detection of targets. This study investigated several aspects of vegetation target detection based on spectral information and developed a low‐cost vegetation sensor. Specific objectives included: (1) compare vegetation‐detection performance using reflected and fluorescence data; (2) evaluate the effect of light source and bandwidth, and select the optimal light source and waveband; and (3) develop a low‐cost vegetation sensor and test its performance under different light conditions.RESULTSThe main outcomes of this study are as follows. (1) The fluorescence excited by blue and red light‐emitting diodes (LEDs) was an effective attribute with which to differentiate vegetation from non‐vegetation and provided results comparative with reflected spectroscopy. (2) A blue LED could excite strong fluorescence and was recommended as the light source. (3) Under illumination by blue and red LEDs, bandwidth did not have any obvious effect on classification accuracy within the studied bandwidths from 0 nm (single wavelength) to 120 nm. (4) A low‐cost vegetation sensor was developed and tested, with 100% detection accuracy in both dark and outdoor environments.CONCLUSIONThis study suggests that single‐waveband fluorescence spectroscopy is an effective approach to detect vegetation targets and low‐cost LEDs can be used for illumination. Light source modulation with a sinusoidal signal is an effective way to resist the influence of environmental light. Overall, the findings of this study contribute to an improved understanding of developing low‐cost and effective vegetation sensors for selective spraying from theory to application. © 2022 Society of Chemical Industry.
Carlina acaulis essential oil nanoemulsion as a new grain protectant against different developmental stages of three stored‐product beetles
Authors: Kavallieratos Nickolas G. , Nika Erifili P. , Skourti Anna , Boukouvala Maria C. , Ntalaka Catherine T. , Maggi Filippo , Spinozzi Eleonora , Petrelli Riccardo , Perinelli Diego Romano , Benelli Giovanni , Canale Angelo , Bonacucina Giulia 
Published: March 2022

AbstractBACKGROUNDPlant essential oils (EOs) represent eco‐friendly alternatives to conventional insecticides for managing pest populations. Carlina acaulis root EO showed a wide insecticidal spectrum, being highly effective against insect pests and vectors, coupled with low mammal toxicity. To boost the chemico‐physical properties of this EO and its main active ingredient, carlina oxide, C. acaulis EO was encapsulated in a nanoemulsion [NE, 6% EO (w/w)], and its insecticidal properties evaluated against larvae and adults of Tribolium castaneum, Tribolium confusum and Tenebrio molitor. Two NE concentrations (500 and 1000 ppm) were applied on stored wheat. Mortality was determined after 4, 8 and 16 h and 1, 2, 3, 4, 5, 6 and 7 days.RESULTSThe NE was toxic to larvae of T. castaneum and T. confusum, killing 93.9% and 98.9% at 1000 ppm after 7 days of exposure, respectively. Tenebrio molitor larvae were tolerant: only 18.9% were dead after 7 days of exposure on stored wheat treated with 1000 ppm NE. However, the NE exhibited high adulticidal activity leading to 85.2% mortality at 1000 ppm, 7 days post‐exposure. The mortalities of T. confusum and T. castaneum adults were low (21.4% and 23.3% respectively) at 1000 ppm, 7 days post‐exposure.CONCLUSIONSA NE based on C. acaulis EO could be regarded as an efficacious green adulticide or larvicide, depending on the target insect species and its life stage, advancing and specifying the pest management strategies of the tested species in an eco‐friendly way. © 2022 Society of Chemical Industry.
Poly‐γ‐glutamic acid application rate effects on hydraulic properties of sandy soil under wetting‐drying cycles conditions
Authors: Liu Lu , Shi Wenjuan , Wang Ying 
Published: March 2022

AbstractWhen amending soil to increase sandy soil water holding capacity, amendment application rate and environment need consideration. Recently, poly‐γ‐glutamic acid (γ‐PGA) as a soil amendment has been increasingly applied in agricultural development. The purpose of this study was to determine the effect of γ‐PGA on soil water retention and soil hydraulic conductivity under wetting‐drying (W‐D) conditions. Specifically, this study investigated the influence of different γ‐PGA application rates (wt%: 0, 0.4, 0.8, 1.2, and 1.6%) on the soil water characteristic curve, saturated hydraulic conductivity (Ks), and the other hydraulic characteristic parameters (saturated water content [θs], field capacity [FC], permanent wilting point [PWP], and available water content [AWC]). Results showed that γ‐PGA significantly increased sandy soil water retention by increasing θs, FC, PWP, and AWC. Poly‐γ‐glutamic acid could decrease the proportion of large pore size (2–15 μm) and Ks and enhance the proportion of particles with small pore size (0.2–2 μm). Nevertheless, the effect of γ‐PGA on hydraulic properties of sandy soil depended on γ‐PGA application rate and the number of W‐D cycles. Under 8‐W‐D and 12‐W‐D, there was no significant difference on soil water retention among all treatments. Increasing the application rate of γ‐PGA was not more effective; P3 (1.2%) and P4 (1.6%) treatments had little difference in soil water holding capacity. This study quantitatively investigated effects of γ‐PGA on soil water retention under different W‐D cycles. Our results suggest that 1.2% might be recommended as an appropriate γ‐PGA application amount.
Brain Targeting, Antioxidant Polymeric Nanoparticles for Stroke Drug Delivery and Therapy
Authors: Wu Haoan , Peng Bin , Mohammed Farrah S. , Gao Xingchun , Qin Zhenpeng , Sheth Kevin N. , Zhou Jiangbing , Jiang Zhaozhong 
Published: March 2022

AbstractIschemic stroke is a leading cause of death and disability and remains without effective treatment options. Improved treatment of stroke requires efficient delivery of multimodal therapy to ischemic brain tissue with high specificity. Here, this article reports the development of multifunctional polymeric nanoparticles (NPs) for both stroke treatment and drug delivery. The NPs are synthesized using an reactive oxygen species (ROS)‐reactive poly (2,2′‐thiodiethylene 3,3′‐thiodipropionate) (PTT) polymer and engineered for brain penetration through both thrombin‐triggered shrinkability and AMD3100‐mediated targeted delivery. It is found that the resulting AMD3100‐conjugated, shrinkable PTT NPs, or ASPTT NPs, efficiently accumulate in the ischemic brain tissue after intravenous administration and function as antioxidant agents for effective stroke treatment. This work shows ASPTT NPs are capable of efficient encapsulation and delivery of glyburide to achieve anti‐edema and antioxidant combination therapy, resulting in therapeutic benefits significantly greater than those by either the NPs or glyburide alone. Due to their high efficiency in brain penetration and excellent antioxidant bioactivity, ASPTT NPs have the potential to be utilized to deliver various therapeutic agents to the brain for effective stroke treatment.
Exploiting the Fracture in Metal‐Organic Frameworks: A General Strategy for Bifunctional Atom‐Precise Nanocluster/ZIF‐8(300 °C) Composites
Authors: Yun Yapei , Fang Yaping , Fu Wengang , Du Wenjun , Zhu Yanan , Sheng Hongting , Astruc Didier , Zhu Manzhou 
Published: March 2022

AbstractAtom‐precise nanoclusters‐metal‐organic framework (APNC/MOF) composites, as bifunctional material with well‐defined structures, have attracted considerable attention in recent years. Despite the progress made to date, there is an urgent need to develop a generic and scalable approach for all APNCs. Herein, the authors present the Exploiting Fracture Strategy (EFS) and successfully construct a super‐stable bifunctional APNC/ZIF‐8(300 °C) composite overcoming the limitations of previous strategies in selecting APNCs. The EFS utilizes the fracture of ZnN in ZIF‐8 after annealing at 300 °C. This method is suitable for all kinds of S/P protected APNCs with different sizes, including uncharged clusters Au1Ag39, Ag40, negatively charged Au12Ag32, positively charged Ag46Au24, Au4Cu4 and P‐ligand‐protected Pd3Cl. Importantly, the generated APNC/MOF show significantly improved performances, for example, the activities of Au12Ag32/ZIF‐8(300°C), Au4Cu4/ZIF‐8(300°C), and Au1Ag39/ZIF‐8(300°C) in the corresponding reactions are higher than those of Au12Ag32, Au4Cu4, and Au1Ag39, respectively. In particular, Au12Ag32/ZIF‐8(300 °C) shows higher activity than Au12Ag32@ZIF‐8. Therefore, this work offers guidance for the design of bifunctional APNC/MOF composites with excellent optimization of properties and opens up new horizons for future related nanomaterial studies and nanocatalyst designs.
Droplet Bouncing: Fundamentals, Regulations, and Applications
Authors: Han Xing , Li Jiaqian , Tang Xin , Li Wei , Zhao Haibo , Yang Ling , Wang Liqiu 
Published: March 2022

AbstractDroplet impact is a ubiquitous phenomenon in nature, daily life, and industrial processes. It is thus crucial to tune the impact outcomes for various applications. As a special outcome of droplet impact, the bouncing of droplets keeps the form of the droplets after the impact and minimizes the energy loss during the impact, being beneficial in many applications. A unified understanding of droplet bouncing is in high demand for effective development of new techniques to serve applications. This review shows the fundamentals, regulations, and applications of millimeter‐sized droplet bouncing on solid surfaces and same/miscible liquids (liquid pool and another droplet). Regulation methods and current applications are summarized, and potential directions are proposed.
Progress in Stimuli‐Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases
Authors: Tapeinos Christos , Gao Han , Bauleth‐Ramos Tomás , Santos Hélder A. 
Published: March 2022

AbstractCardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic stroke are the leading causes of death worldwide, resulting in 16% and 11% of deaths globally. Although several therapeutic approaches are presented over the years, the continuously increasing mortality rates suggest the need for more advanced strategies for their treatment. One of these strategies lies in the use of stimuli‐responsive biomaterials. These “smart” biomaterials can specifically target the diseased tissue, and after “reading” the altered environmental cues, they can respond by altering their physicochemical properties and/or their morphology. In this review, the progress in the field of stimuli‐responsive biomaterials for CCVDs in the last five years, aiming at highlighting their potential as early‐stage therapeutics in the preclinical scenery, is described.