bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of three MR perfusion software packages in predicting final infarct volume after mechanical thrombectomy
Authors: Bani-Sadr Alexandre , Cho Tae-Hee , Cappucci Matteo , Hermier Marc , Ameli Roxana , Filip Andrea , Riva Roberto , Derex Laurent , De Bourguignon Charles , Mechtouff Laura , Eker Omer F , Nighoghossian Norbert , Berthezene Yves 
Published: March 2022

AimsTo evaluate the performance of three MR perfusion software packages (A: RAPID; B: OleaSphere; and C: Philips) in predicting final infarct volume (FIV).MethodsThis cohort study included patients treated with mechanical thrombectomy following an admission MRI and undergoing a follow-up MRI. Admission MRIs were post-processed by three packages to quantify ischemic core and perfusion deficit volume (PDV). Automatic package outputs (uncorrected volumes) were collected and corrected by an expert. Successful revascularization was defined as a modified Thrombolysis in Cerebral Infarction (mTICI) score ≥2B. Uncorrected and corrected volumes were compared between each package and with FIV according to mTICI score.ResultsNinety-four patients were included, of whom 67 (71.28%) had a mTICI score ≥2B. In patients with successful revascularization, ischemic core volumes did not differ significantly from FIV regardless of the package used for uncorrected and corrected volumes (p>0.15). Conversely, assessment of PDV showed significant differences for uncorrected volumes. In patients with unsuccessful revascularization, the uncorrected PDV of packages A (median absolute difference −40.9 mL) and B (median absolute difference −67.0 mL) overestimated FIV to a lesser degree than package C (median absolute difference −118.7 mL; p=0.03 and p=0.12, respectively). After correction, PDV did not differ significantly from FIV for all three packages (p≥0.99).ConclusionsAutomated MRI perfusion software packages estimate FIV with high variability in measurement despite using the same dataset. This highlights the need for routine expert evaluation and correction of automated package output data for appropriate patient management.
Occupational exposures to pesticides and other chemicals: a New Zealand motor neuron disease case–control study
Authors: Chen Grace Xia , Douwes J , van den Berg Leonard , Pearce Neil , Kromhout Hans , Glass Bill , McLean David J , 't Mannetje Andrea Martine 
Published: March 2022

ObjectivesTo assess associations between occupational exposures to pesticides and other chemicals and motor neuron disease (MND).MethodsA population-based case–control study that included 319 MND cases (64% male/36% female) recruited through the New Zealand MND Association complemented with hospital discharge data, and 604 controls identified from the Electoral Roll. For each job held, a questionnaire collected information on 11 exposure categories (dust, fibres, tobacco smoke, fumes, gas, fumigants, oils/solvents, acids/alkalis, pesticides, other chemicals and animals/animal products). ORs were estimated using logistic regression adjusting for age, sex, ethnicity, socioeconomic status, education, smoking, alcohol consumption, physical activities, head/spine injury and other occupational exposures.ResultsTwo exposure categories were associated with increased MND risks: pesticides (OR 1.70, 95% CI 1.17 to 2.48) and fumigants (OR 3.98, 95% CI 1.81 to 8.76), with risks increasing with longer exposure duration (p<0.01). Associations were also observed for: methyl bromide (OR 5.28, 95% CI 1.63 to 17.15), organochlorine insecticides (OR 3.28, 95% CI 1.18 to 9.07), organophosphate insecticides (OR 3.11, 95% CI 1.40 to 6.94), pyrethroid insecticides (OR 6.38, 95% CI 1.13 to 35.96), inorganic (copper) fungicides (OR 4.66, 95% CI 1.53 to 14.19), petrol/diesel fuel (OR 2.24, 95% CI 1.27 to 3.93) and unspecified solvents (OR 1.91, 95% CI 1.22 to 2.99). In women, exposure to textile fibres (OR 2.49, 95% CI 1.13 to 5.50), disinfectants (OR 9.66, 95% CI 1.29 to 72.44) and cleaning products (OR 3.53, 95% CI 1.64 to 7.59) were also associated with MND; this was not observed in men (OR 0.80, 95% CI 0.44 to 1.48; OR 0.72, 95% CI 0.29 to 1.84; OR 0.57, 95% CI 0.21 to 1.56, respectively).ConclusionsThis study adds to the evidence that pesticides, especially insecticides, fungicides, and fumigants, are risk factors for MND.
Occupational lifting, carrying, pushing, pulling loads and risk of surgery for subacromial impingement syndrome: a register-based cohort study
Authors: Riddervold Bjørn , Andersen Johan Hviid , Dalbøge Annett 
Published: March 2022

AimThe aim was to examine exposure–response relations between surgery for subacromial impingement syndrome (SIS) and intensities of lifting/carrying and pushing/pulling loads during a 10-year time window.MethodsWe conducted a register-based cohort study (2003–2008), comprising persons born in Denmark (1933–1977) with ≥5 years of work experience (N=2 374 403). Information on surgery for SIS was retrieved from the Danish National Patient Register (N=14 188). Occupational mechanical exposures comprising lifting/carrying loads ≥10 kg and pushing/pulling loads ≥50 kg were assessed by combining individual register-based job codes with our expert-based Shoulder job exposure matrix. We created three intensity-specific exposure duration variables by dividing the intensity for lifting/carrying and pushing/pulling loads into three categories (low, medium and high), and summed up number of years in each exposure category for a 10-year time window. The associations were analysed using logistic regression technique equivalent to discrete survival analysis.ResultsThe adjusted OR (ORadj) increased with both exposure duration and intensity of lifting/carrying and pushing/pulling. For lifting/carrying, the ORadjreached a maximum of 1.78 (95% CI 1.66 to 1.89), 2.52 (95% CI 2.32 to 2.74) and 2.96 (95% CI 2.53 to 3.47) after 10 years of exposures for the three exposure intensities. For pushing/pulling, maximum ORadjwas 1.44 (95% CI 1.31 to 1.58), 1.68 (95% CI 1.58 to 1.79) and 1.72 (95% CI 1.50 to 2.00), respectively.ConclusionWe found exposure–response relations for lifting/carrying and pushing/pulling across the 10-year time window. The risk was especially pronounced for lifting/carrying compared with pushing/pulling. We did not find indications of safe exposure intensities.
Silica and nitrogen-doped carbon co-coated lithium manganese iron phosphate microspheres as cathode materials for lithium batteries
Authors: Liu Jiangtao , Shi Jiayuan , Wang Zhenbo 
Published: March 2022

Lithium manganese iron phosphate (LiMn1-xFexPO4, LMFP) combines the advantages of LiFePO4 and LiMnPO4. However, low electronic conductivity and sluggish lithium ion diffusion of the LMFP cathode limits its commercial application. In this work, the LMFP microspheres were co-coated by silica and N-doped carbon for the improvement of electronic and ionic conductivity of LMFP. The hydrolysis of tetraethyl orthosilicate and the polymerization of dopamine can be mutually promoted in one reaction system to realize the simultaneous precipitation of Si and C species on the LMFP surfaces without the addition of acid–base catalysts or buffering agents. After high-temperature treatment in argon, the silica and N-doped carbon co-coated LMFP microspheres were obtained with improved cycling stability (84.4% of capacity retention for 300 cycles at 1 C) and enhanced rate performance (80.0 mAh g−1 at 5 C). Therefore, this work shows a facile and common method for the composite coating of cathode materials.
Simulation-based design study for the passive shielding of the COSINUS dark matter experiment
Authors: Angloher G. , Dafinei I. , Marco N. Di , Ferroni F. , Fichtinger S. , Filipponi A. , Friedl M. , Fuss A. , Ge Z. , Heikinheimo M. , Huitu K. , Maji R. , Mancuso M. , Pagnanini L. , Petricca F. , Pirro S. , Pröbst F. , Profeta G. , Puiu A. , Reindl F. , Schäffner K. , Schieck J. , Schmiedmayer D. , Schwertner C. , Stahlberg M. , Stendahl A. , Wagner F. , Yue S. , Zema V. , Zhu Y. ,   (The COSINUS Collaboration), Pandola L. 
Published: March 2022

AbstractThe COSINUS (Cryogenic Observatory for SIgnatures seen in Next-generation Underground Searches) experiment aims at the detection of dark matter-induced recoils in sodium iodide (NaI) crystals operated as scintillating cryogenic calorimeters. The detection of both scintillation light and phonons allows performing an event-by-event signal to background discrimination, thus enhancing the sensitivity of the experiment. The choice of using NaI crystals is motivated by the goal of probing the long-standing DAMA/LIBRA results using the same target material. The construction of the experimental facility is foreseen to start by 2021 at the INFN Gran Sasso National Laboratory (LNGS) in Italy. It consists of a cryostat housing the target crystals shielded from the external radioactivity by a water tank acting, at the same time, as an active veto against cosmic ray-induced events. Taking into account both environmental radioactivity and intrinsic contamination of materials used for cryostat, shielding and infrastructure, we performed a careful background budget estimation. The goal is to evaluate the number of events that could mimic or interfere with signal detection while optimising the geometry of the experimental setup. In this paper we present the results of the detailed Monte Carlo simulations we performed, together with the final design of the setup that minimises the residual amount of background particles reaching the detector volume.
IVF Outcome in Patients with Different Stages of Endometriosis: Can AMH Be a Predictor?
Authors: Marwaha Amarpreet Kaur 
Published: March 2022

Background and Objectives: The role of Anti Mullerian Hormone (AMH) in determining the outcome of in vitro fertilization (IVF) in endometriosis has been controversial. This study was conducted to assess whether AMH can predict poor response in endometriosis patients undergoing IVF and to compare the IVF outcomes among the different stages of endometriosis. Methodology: A retrospective study was conducted among 90 endometriosis patients undergoing IVF using the flexible antagonist protocol from January 2016 to December 2018 at DY Patil Medical College, Navi Mumbai. Serum AMH levels were obtained from different patients, primary outcome being clinical pregnancy rate (CPR) while the secondary outcome included the number of oocytes retrieved, number of mature oocytes obtained, fertilization rates (FR), and number of good quality embryos formed. Data was analyzed with SPSS 16.0. Mann-Whitney U and chi-square tests were used to compare the outcomes of IVF with AMH level in different stages of endometriosis. Receiver Operator Characteristic (ROC) curves were plotted to know the predictive ability of AMH by determining the area under the curve (AUC), P value < 0.05 was considered significant for all statistical tests. Results: AUC was found to be significant for AMH in detecting poor response among those with late staged endometriosis but with poor accuracy (AUC = 0.65, P = 0.02∗). Considering a median AMH level of 1.24 ng/mL with sensitivity and specificity of > 60%, the primary and secondary outcomes were significantly higher among those with median AMH levels of more than 1.24 ng/mL compared to those with the median ≤ 1.24 ng/mL. The significance, however, was mainly found in the late stages of endometriosis (P < 0.05). Fertilization rates, good quality embryos, and CPR did not vary with AMH levels among those with early stages of endometriosis (P > 0.05). The outcomes of IVF did not vary significantly across the different stages of endometriosis except for good quality embryos which were formed in patients with early staged endometriosis (P < 0.05). Conclusion: AMH levels may be a predictor of nonconception with poor accuracy in late stages of endometriosis (III/IV), while good quality embryos were obtained in patients with early stages of endometriosis.
IP-Se-06, a Selenylated Imidazo[1,2-a]pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF-1α and MAPK Signaling Inhibition, Promoting Antiproliferative Effect and Apoptosis in Glioblastoma Cells
Authors: dos Santos Daniela C. , Rafique Jamal , Saba Sumbal , Grinevicius Valdelúcia M. A. S. , Filho Danilo W. , Zamoner Ariane , Braga Antonio L. , Pedrosa Rozangela C. , Ourique Fabiana 
Published: March 2022

Glioblastoma multiforme (GBM) is a notably lethal brain tumor associated with high proliferation rate and therapeutic resistance, while currently effective treatment options are still lacking. Imidazo[1,2-a]pyridine derivatives and organoselenium compounds are largely used in medicinal chemistry and drug development. This study is aimed at further investigating the antitumor mechanism of IP-Se-06 (3-((2-methoxyphenyl)selanyl)-7-methyl-2-phenylimidazol[1,2-a]pyridine), a selenylated imidazo[1,2-a]pyridine derivative in glioblastoma cells. IP-Se-06 exhibited high cytotoxicity against A172 cells (

I

C

50

=
1.8

μ
M

) and selectivity for this glioblastoma cell. The IP-Se-06 compound has pharmacological properties verified in its ADMET profile, especially related to blood-brain barrier (BBB) permeability. At low concentration (1 μM), IP-Se-06 induced intracellular redox state modulation with depletion of TrxR and GSH levels as well as inhibition of NRF2 protein. IP-Se-06 also decreased mitochondrial membrane potential, induced cytochrome c release, and chromatin condensation. Furthermore, IP-Se-06 induced apoptosis by decreasing levels of Bcl-xL while increasing levels of γ-H2AX and p53 proteins. Treatment with IP-Se-06 induced cell cycle arrest and showed antiproliferative effect by inhibition of Akt/mTOR/HIF-1α and ERK 1/2 signaling pathways. In addition, IP-Se-06 displayed significant inhibition of p38 MAPK and p-p38, leading to inhibition of inflammasome complex proteins (NLRP3 and caspase-1) in glioblastoma cells. These collective findings demonstrated that IP-Se-06 is a bioactive molecule that can be considered a candidate for the development of a novel drug for glioblastoma treatment.
The Impact of Systolic Blood Pressure, Pulse Pressure, and Their Variability on Diabetes Retinopathy among Patients with Type 2 Diabetes
Authors: Lou Qingqing , Chen Xue , Wang Kun , Liu Huanhuan , Zhang Zongjun , Lee Yaujiunn 
Published: March 2022

Objectives. To evaluate the effects of variations in systolic blood pressure (SBP) and pulse pressure (PP) on diabetic retinopathy (DR) in patients with type 2 diabetes. Methods. A total of 3275 type 2 diabetes patients without DR at Taiwan Lee’s United Clinic from 2002 to 2014 were enrolled in the study. The average age of the patients was 65.5 (±12.2) years, and the follow-up period ranged from 3 to 10 years. Blood pressure variability was defined as the standard deviation (SD) of the average blood pressure values over the entire study period and was calculated for each patient. The mean SD for SBP was 11.16, and a

SBP
≥
130

mmHg

(

1

mmHg
=
0.133

kPa

) was defined as high SBP. Based on these data, patients were divided into four groups as follows: group 1 (G1,

mean

SBP
<
130

mmHg

,

SD

of

SBP
<
11.16

mmHg

), group 2 (G2,

mean

SBP
<
130

mmHg

,

SD
≥
11.16

mmHg

), group 3 (G3,

mean

SBP
≥
130

mmHg

,

SD

of

SBP
<
11.16

mmHg

), and group 4 (G4,

mean

SBP
≥
130

mmHg

,

SD
≥
11.16

mmHg

). Based on a mean PP of 80 mmHg with a pulse pressure SD of 6.53 mmHg, the patients were regrouped into four groups designated G1

′

-G4

′

. Results. After adjusting for patient age, sex, and disease course, Cox regression showed that the mean and SD of SBP, pulse pressure, and their SDs were risk factors for DR. After stratifying the patients based on the mean and SD of the SBP, we found that the patients in the G4 group had the highest risk of DR (

hazard

ratio

HR

=
1.980

, 95% CI: 1.716~2.285,

P
<
0.01

) and patients in the G1 group had the lowest risk. Patients in the G3 group (

HR
=
1.409

, 95% CI: 1.284~1.546,

P
<
0.01

) had a higher risk of DR compared to those in the G2 group (

HR
=
1.353

, 95% CI: 1.116~1.640,

P
<
0.01

). After the restratification of patients based on the mean and SD of the pulse pressures, it was found that patients in the G2

′

group had the highest risk of DR (

HR
=
2.086

, 95% CI: 1.641~2.652,

P
<
0.01

), whilst patients in the G1

′

group had the lowest risk. Also, the risk of DR in the G4

′

group (

HR
=
1.507

, 95% CI: 1.135~2.000,

P
<
0.01

) was higher than that in the G3

′

group (

HR
=
1.289

, 95% CI: 1.181~1.408,

P
<
0.01

). Conclusions. Variability in SBP and PP are risk factors for DR in patients with type 2 diabetes. The variability of PP was better able to predict the occurrence of DR than mean pulse pressure.
Paediatric Crohn’s Disease Patients Have Increased Inflammatory Markers Compared to Adult Patients prior to Biological Treatment
Authors: Bouazzi Meyya , Bak Nina F. , Agnholt Jørgen , Wewer Vibeke , Malham Mikkel , Bendix Mia 
Published: March 2022

Background. Recent epidemiological studies in inflammatory bowel disease (IBD) indicate that paediatric onset of IBD (pIBD) more often requires biological therapy compared to adult onset of IBD (aIBD). Whether this is due to a more aggressive disease phenotype or lower threshold of prescribing biologicals is unknown. In order to expand these findings in a clinical setting, we compared the inflammatory burden in pIBD and aIBD patients requiring biological therapy. Methods. We retrospectively included 70 pIBD and 83 aIBD patients initiating biological therapy. Symptoms and biomarker levels were recorded prior to and 6, 14, 22, and 52 weeks after initiation of biological therapy. Results. In Crohn’s disease (CD), the baseline levels of faecal calprotectin and C-reactive protein (CRP) were increased in paediatric CD patients compared to adult CD patients (

p
<
0.0001

and

p
=
0.01

, respectively). No significant differences were seen in ulcerative colitis (UC). In CD, baseline vitamin D

levels
≥
75

nmol/L and baseline CRP

levels
<
5

mg/L were associated with higher remission rate (

p
=
0.02

) at the end of follow-up. Moreover, aIBD patients had a higher risk of loss of response to biological therapy and treatment discontinuation compared to pIBD patients (

HR
=
4.7

[1.6-13.4],

p
=
0.004

). Conclusions. pCD patients had increased inflammation markers compared to aCD patients prior to biological treatment. In addition to this,

vitamin

D
<
75

nmol/L and high CRP levels predicted poor response to treatment in IBD patients.
Forkhead Box Transcription Factors: Double-Edged Swords in Cancer
Authors: Castaneda Maria , Hollander Petra den , Mani Sendurai A. 
Published: March 2022

AbstractA plethora of treatment options exist for cancer therapeutics, but many are limited by side effects and either intrinsic or acquired resistance. The need for more effective targeted cancer treatment has led to the focus on forkhead box (FOX) transcription factors as possible drug targets. Forkhead factors such as FOXA1 and FOXM1 are involved in hormone regulation, immune system modulation, and disease progression through their regulation of the epithelial–mesenchymal transition. Forkhead factors can influence cancer development, progression, metastasis, and drug resistance. In this review, we discuss the various roles of forkhead factors in biological processes that support cancer as well as their function as pioneering factors and their potential as targetable transcription factors in the fight against cancer.
A note on sex ratio, size at maturity, fecundity and breeding season of the portunid crab, Thranita crenata (Rüppell, 1830) from the Pakistani coast
Authors: Mustaquim Javed , Khatoon Sumaira , Rashid Shahnaz 
Published: March 2022

Abstract
Specimens of the portunid crab, Thranita crenata (Rüppell, 1830), commonly known as spiny rock crab or crenate swimming crab, were collected from Buleji rocky shore, in Karachi, during March 2015 to February 2016. The size (recorded as carapace width measured between the tips of the 5th spines) at which male and female crabs attain maturity was 42.6 mm and 42.4 mm CW, respectively. The smallest size of an ovigerous female crab was 38 mm CW. Although there were some more male crabs than female crabs in the samples, the male to female ratio was not significantly different from 11 (). Sex ratios in different size groups and different months were also found insignificantly different from a 11 ratio. Ovigerous females were found throughout the year, with a major peak in May and a minor peak in October when, respectively, 30.04% and 25.12% of the female crabs were ovigerous. The minimum and maximum fecundities recorded were 42 800 and 193 433 in females of 35 mm and 77 mm CW, respectively, and the average fecundity was 107 856 ± 50 331 over all berried females.
Moult cycle staging in decapod crustaceans (Pleocyemata) and the Australian crayfish, Cherax destructor Clark, 1936 (Decapoda, Parastacidae)
Authors: Gorissen Sarsha , Sandeman David 
Published: March 2022

Abstract
We tabulated decades of published moult stage criteria of Decapoda: Pleocyemata on setogenesis and changes in pleopods, uropods and gastroliths; and reviewed them focusing on the comparative biology of Cherax destructor. We found their staging criteria relatively consistent. For C. destructor, lacking were a comprehensive description with micrographs; a juvenile application; and, known stage duration. Therefore, we developed comprehensive moult staging techniques in juvenile C. destructor using pleopods, antennules and gastroliths. Using pleopod staging, we found C. destructor exhibits anecdysis as a true transition stage (D0), which occupied around half the moult cycle. We successfully applied this method to juvenile and adult marbled crayfish. We report on these suggested novel techniques: moult staging using pleopods: novel in crayfish; moult staging using antennules: novel in decapods; moult staging using gastrolith deposition: novel in C. destructor; and, calculating the gastrolith moult mineralization index using height: novel in decapods.
Multigene phylogeny reveals the ribbed shell morphotypes in the land snail genus Sarika (Eupulmonata: Ariophantidae), with description of two new species from Thailand and Myanmar
Authors: Pholyotha Arthit , Sutcharit Chirasak , Lin Aung , Panha Somsak 
Published: March 2022

Abstract
The speciose land snail genus Sarika is widely distributed throughout mainland Southeast Asia. This genus is generally recognized by a smooth and polished shell. However, we recognize four species with a ribbed shell surface (S. siamensis, S. theodori, S. costabilis sp. nov., and S. costata sp. nov.) exhibiting genital characters similar to those of Sarika s.s. and so a rearrangement in the systematics of the genus is suggested. Here, we analysed these four ribbed shell species together with Sarika s.s. by a combined morphological and molecular approach to species delineation, the latter based on both mitochondrial (coi and 16S) and nuclear (28S) markers. Our molecular phylogeny affirms the monophyly of the genus Sarika including both smooth and ribbed shell morphotypes that is statistically well supported. The ribbed shell morphotype in the land snail genus Sarika is also well defined in terms of diagnostic morpho-anatomical characters that can be divided into two species groups. The S. costata species group consists of only one species, S. costata sp. nov., while the S. siamensis species group comprises S. siamensis, S. theodori and S. costabilis sp. nov. These findings provide a solid basis for the systematics of family Ariophantidae.