bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of COVID-19 on Healthy Related Issues, A structured Review
Authors: Al-Hamamy Hiyam Rauof 
Published: January 2022

Coronavirus: (COVID-19) is a recently discovered viral disease caused by a new strain of coronavirus.
The majority of patients with corona-virus infections will have a mild-moderate respiratory disease that recovers without special care. Most often, the elderly, and others with chronic medical conditions such as asthma, coronary disease, respiratory illness, and malignancy are seriously ill.
COVID-19 is spread mostly by salivary droplets or nasal secretions when an infected person coughs or sneezes.
COVID-19 causes severe acute respiratory illness (SARS-COV-2). The first incidence was recorded in Wuhan, China, in 2019. Since then it spreads leading to a pandemic.
The typical incubation time for COVID-19 infection is 2-14 days (normally 5). The common features include fever, cough, tiredness, difficulty in breathing, loss of smell or taste. Occasionally, signs are absent. COVID-19 complications include renal failure, syndrome of cytokine release, pneumonia, respiratory failure, lung fibrosis.
Vitamin D deficiency/ insufficiency and some of its related factors in a sample of Iraqi pregnant women and their neonates at Al-Elwiya Maternity Teaching Hospital during 2019
Authors: Obaid Ali Abdul Razzak , Hussein Mohammed Jalal 
Published: January 2022

In their cross-sectional study, Al-Rubaye et al studied the extent of vitamin D (VD) deficiency/ insufficiency, factors affecting its degree, and the adverse outcomes of the altered VD status among a group of mothers and their neonates from Baghdad, Iraq. They found that 96.6% of the mothers had VD deficiency/ insufficiency compared to 86.4% in their neonates. Maternal VD levels and neonatal weights were significantly correlated with neonatal VD levels. We believe that the study results need to be revised. This is based two points listed in this letter to editor
MENINGKATKAN KEDISIPLINAN GURU SMK IT KHOIRU UMMAH REJANG LEBONG DENGAN PROGRAM FINGER PRINT “RENKEHATU”
Authors: Effendi Rajab , Warlizasusi Jumira 
Published: January 2022

Disiplin di tempat bekerja tidak hanya semata-mata patuh dan taat terhadap sesuatu yang kasat mata, seperti penggunaan seragam kerja, datang dan pulang sesuai jam kerja, tetapi juga patuh dan taat terhadap sesuatu yang tidak kasat mata yang melibatkan komitmen, baik dengan diri sendiri ataupun komitmen dengan sekolah atau suatu instansi. Faktor pendukung dominan bagi kedisiplinan guru berasal dari dalam diri guru sendiri. Faktor-faktor tersebut yaitu kompetensi profesional, motivasi, kreativitas, dan produktivitas guru, pendidikan, serta karakter guru.
Penelitian ini menggunakan pendekatan kualitatif yakni metode penelitian yang digunakan untuk meneliti kondisi obyek yang alamiah, dimana peneliti adalah sebagai instrumen kunci, teknik pengumpulan data dilakukan analisa data bersifat induktif/kualitatif, dan hasil penelitian kualitatif lebih menekankan makna dari pada generalisasi.
Hasil analisis menunjukkan bahwa Program Finger Print Rengkehatu di SMK IT Khoiru Ummah dapat disimpulkan efektif diterapkan untuk meningkatkan motivasi guru agar hadir tepat waktu. Dari sisi kemampuan adaptasi dalam penggunaan Finger print Rengkehatu dalam meningkatkan disiplin kerja guru sebelumnya masih banyak yang terlambat,akan tetapi dengan program Finger Print Rengkehatu setelah diakumulasi data secara digital keterlambatan semakin berkurang hingga semua tepat waktu, Bahan ini juga kemudian dijadikan bahan kepala sekolah untuk mengevaluasi kinerja guru terutama terhadap kedisiplinan guru.
A comparative experiment on the anti-chronic myeloid leukemia capacities of AgNO3, ‎Scrophularia striata leaf aqueous extract, and silver nanoparticles containing natural ‎compounds ‎
Authors: Ma Yanmei , Behtash Maryam , Yari Hadis , Karimian Mohammad , Abbasi Naser , Ghaneialvar Hori , Zangeneh Mohammad Mahdi 
Published: January 2022

IntroductionIn the current study, silver nanoparticles were prepared and synthesized in aqueous medium using Scrophularia ‎striata leaf extract as stabilizing and reducing agents. Also, we investigated the anti-chronic myeloid leukemia ‎potentials of silver nanoparticles against BV173 (chronic myeloid leukemia in blast crisis), CML-T1 (chronic ‎myeloid leukemia in lymphoid blast crisis), EM-2 (chronic myeloid leukemia in blast crisis; relapse after bone ‎marrow transplantation), and JOSK-M (chronic myeloid leukemia in myelomonocytic) cell lines. ‎Material and methodsSilver nanoparticles were characterized and analyzed using common nanotechnology techniques including UV-‎Vis.‎‏ ‏and FT-IR Spectroscopy, Field Emission-Scanning Electron Microscopy (FE-SEM), and Transmission ‎Electron Microscopy (TEM), and Energy Dispersive X‐ray Spectrometry (EDS). ‎ResultsFT-IR analysis offered antioxidant compounds in the nanoparticles were the sources of reducing power, ‎reducing silver ions to silver nanoparticles. FE-SEM and TEM images revealed a uniform spherical morphology ‎in size of 19.72 nm for the green synthesized nanoparticles. DPPH test revealed similar antioxidant potentials ‎for silver nanoparticles and butylated hydroxytoluene. Silver nanoparticles had very low cell viability and anti-‎chronic myeloid leukemia properties dose-dependently against JOSK-M, EM-2, CML-T1, and BV173 cell lines ‎without any cytotoxicity on the HUVEC cell line. The best result of cytotoxicity properties of silver ‎nanoparticles against the above cell lines was observed in the case of CML-T1 cell line. ‎ConclusionsAfter confirming in the in vivo and clinical trial studies, these nanoparticles can be administrated in humans for ‎the treatment of chronic myeloid leukemia.‎
IL-36γ promotes psoriasis-like features in keratinocytes in an imiquimod-induced murine model of psoriasis
Authors: Wang Wen-Ming , Wu Chao , Gao Yi-Meng , Jin Hong-Zhong 
Published: January 2022

IntroductionPsoriasis is a recurrent, chronic inflammatory skin disease with complex pathogenesis. The disease imposes a heavy burden on patients. Interleukin (IL)-36γ belongs to the IL-36 family and is predominantly expressed by epithelial cells. IL-36γ is upregulated in psoriasis lesions. However, the effects of IL-36γ in keratinocytes remain unclear.Material and methodsEighteen IL-36γ-deficient mice were divided into three groups: the vaseline group, the imiquimod (IMQ) group, and the IMQ/IL-36γ group. Vaseline or IMQ was administered for 6 consecutive days. The severity of psoriasis-like lesions was evaluated using a modified Psoriasis Area and Severity Index (PASI) scoring system. Production of cytokines and expression of differentiation markers were assessed by immunohistochemistry.ResultsIMQ-induced psoriasis lesions were significantly more severe in IMQ/IL-36γ-treated mice compared with vaseline-treated and IMQ-treated mice, as shown by an exacerbated inflammatory phenotype, increased numbers of blood vessels, increased infiltration of cells, and increased epidermal thickness. Expression of loricrin and keratin 5 in skin lesions was decreased following treatment with IL-36γ. Levels of IL-17A, interferon-γ, β-catenin and Dickkopf-related protein 1 were elevated in keratinocytes within psoriatic lesions following IL-36γ stimulation.ConclusionsTogether, these data showed that IL-36γ contribute to abnormal keratinocytes proliferation and keratinocyte-related proinflammatory cytokines, and suggest that IL-36γ may play an important role in the pathogenesis of psoriasis.
Peningkatan Motivasi Belajar Menggunakan Project Based Learning (PjBL) melalui Media Vlog Materi Senam Aerobik
Authors: Zaeriyah Siti 
Published: January 2022

Pembelajaran daring saat ini dilaksanakan untuk mengatasi kesulitan proses belajar tatap muka akibat adanya pandemi COVID-19. Maka dari itu, penelitian ini bertujuan untuk menjabarkan pelaksanaan peningkatan motivasi belajar siswa menggunakan Project Based Learning (PjBL) media vlog dengan materi senam aerobik di SMA N 5 Yogyakarta. Penelitian ini dilaksanakan pada kelas XII IPS 2 berisi 32 siswa pada semester 2 tahun pelajaran 2020/2021 Penelitian ini adalah Penelitian Tindakan Kelas (PTK) yang dilaksanakan dalam dua siklus. Instrumen pengambilan data yang digunakan adalah angket motivasi, hasil observasi, hasil catatan lapangan, dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif kualitatif untuk menjelaskan hasil perhitungan angket motivasi siswa pada tiap aspek yang diamati. Hasil penelitian menunjukkan bahwa pembelajaran model Project Based Learning (PjBL) berbasis vlog dapat meningkatkan motivasi belajar materi senam aerobik untuk siswa kelas XII IPS 2 SMA Negeri 5 Yogyakarta. Pada Siklus 1 motivasi belajar siswa mencapai kategori tinggi sedangkan motivasi belajar siswa pada Siklus 2 mencapai kategori sangat tinggi. Berdasarkan indikator keberhasilan, maka disimpulkan bahwa pencapaian motivasi belajar siswa pada Siklus 1 baru sebesar 74, 75. Sedangkan pada Siklus 2 pencapaian motivasi belajar siswa sebesar 87, 25 sehingga sudah mencapai keberhasilan.
Pengembangan Desain Blended Learning Mata Pelajaran Fisika SMA pada Era Kenormalan Baru
Authors: Kusyanti Rita Nunung Tri 
Published: January 2022

Tujuan penelitian ini untuk mengembangkan desain pembelajaran blended learning pada mata pelajaran Fisika kelas XI di masa era kenormalan baru. Penelitian ini adalah penelitian pengembangan R&D dengan model ADDIE. Tahapan penelitian ini, hanya sampai pada tahapan kedua yaitu analisis kebutuhan dan desain rancangan model pembelajaran blended. Teknik pengumpulan data menggunakan lembar observasi untuk memvalidasi rancangan (brief design) pembelajaran blended, instrumen penelitian berupa lembar observasi, analisa data secara kualitatif. Perencanaan desain produk dengan menyusun desain pembelajaran blended dengan mengacu pada kompetensi matapelajaran Fisika pada masa darurat C-19 dengan sintak blended learning. Berdasar analisis kebutuhan pembelajaran blended learning paling efektif untuk diterapkan pada era kenormalan baru. Desain pembelajaran (brief design) blended learning Fisika model flipped classroom dengan memperhatikan variasi tatap muka pembelajaran offline dan pembelajaran online dengan prosentasi 50%-50%. Hasil validasi ahli media dan materi diperoleh penilaian obyek pembelajaran mengadaptasi dari LORI adalah adalah 81,58% masuk kategori setuju dan 85,52% masuk kategori sangat setuju, kuesioner evaluasi proses pembelajaran daring adalah 81,25 % masuk kategari cukup baik, dan 89,58% masuk kategori sangat baik, penilaian desain pembelajaran blended learning adalah 85% masuk kategari setuju dan 90% masuk kategori sangat setuju. Rerata aspek atau indikator 85,48% maka hasil validasi ahli isi materi dan media desain pembelajaran blended yang dikembangkan bisa diuji cobakan karena sudah memasuki klasifikasi baik (mendekati sangat baik).
Penerapan Blended Learning untuk Meningkatkan Minat dan Prestasi Belajar pada Pembelajaran Matematika
Authors: Winanti Anggraeni Ratna 
Published: January 2022

Penelitian tindakan kelas ini bertujuan untuk meningkatkan minat dan prestasi belajar siswa pada pembelajaran matematika melalui blended learning. Penelitian dilakukan dalam dua siklus dengan tiap siklusnya menggunakan empat komponen yakni planning, act, observing, dan reflecting. Subjek pada penelitian ini adalah siswa kelas XI IPS 2 SMA Negeri 1 Bambanglipuro Tahun Pelajaran 2020/2021. Teknik pengumpulan data yang digunakan pada penelitian ini adalah lembar observasi guru, lembar observasi siswa, instrumen angket minat belajar siswa dan instrumen tes prestasi belajar siswa. Analisis data pada penelitian ini mencakup penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa; 1) penggunaan blended learning mampu meningkatkan minat belajar siswa dilihat dari data pada siklus II telah mencapai indikator keberhasilan yakni sebesar 33,33% siswa memiliki minat sangat tinggi, 66,67% siswa memiliki minat tinggi dalam kelas tersebut; 2) penggunaan blended learning mampu meningkatkan prestasi belajar siswa hal ini dapat dilihat dari data pada siklus II telah mencapai indikator keberhasilan sebesar 76,67% yakni 23 siswa telah tuntas dari 30 siswa di dalam kelasnya, dan 3) hasil observasi pelaksanaan blended learning pada siklus II telah mencapai indikator keberhasilan dengan persentase sebesar 96,67%. Dari keseluruhan hasil penelitian, blended learning disimpulkan mampu meningkatkan minat dan prestasi belajar siswa pada pembelajaran matematika.
Penerapan Model Gradual Release of Responsibility dalam Penguatan Pembelajaran Literasi dan Numerasi
Authors: Herawati Reni 
Published: January 2022

Best Practice dilakukan berdasarkan urgensi penguatan pembelajaran literasi dan numerasi dengan melibatkan enam sekolah binaan pada SMA di Kota Yogyakarta. Model Gradual Release of Responsibility mengaktualisasikan pelepasan tanggung jawab secara bertahap, meliputi langkah: 1) focused lesson, 2) Guided Instruction, 3) Collaborative Learning, dan 4) Individual Work untuk meningkatkan pemahaman dan keterampilan guru dalam pembelajaran literasi dan numerasi. Analisis data menunjukkan peningkatan pemahaman guru tentang literasi dalam pembelajaran dari 56% menjadi 69%, atau meningkat 13%. Sementara itu, pemahahaman guru tentang numerasi dalam pembelajaran merangkak dari 36% menjadi 61%, meningkat 25%. Keterampilan guru dalam menyusun perencanaan pembelajaran literasi mengalami peningkatan sebesar 15%, dari 70% menjadi 85%. Keterampilan guru dalam perencanaan pembelajaran numerasi mengalami peningkatan tajam sebesar 35%, dari 38% menjadi 75%. Data ini menunjukkan pembimbingan dengan model Gradual Release of Responsibility berdampak signifikan walaupun belum mencapai hasil optimal. Kendala dalam pelaksanaan pembimbingan ditemukan berkaitan dengan terbatasnya waktu akibat bersamaan dengan kegiatan penuntasan vaksin bagi guru dan siswa serta persiapan pembelajaran tatap muka terbatas. Terbatasnya literatur tentang implementasi model Gradual Release of Responsibility dalam kepengawasan sekolah menjadikan hasil dan temuan best practice ini sebagai wawasan baru dan merupakan kebaruan yang sangat bermanfaat baik dalam tataran praktek maupun teori. Selanjutnya direkomendasikan bagi pengawas dan sekolah untuk mengadopsi model Gradual Release of Responsibility baik untuk pembimbingan guru maupun siswa dalam meningkatkan kemampuan literasi dan numerasi.
IRON DEPOSITION IN THE GROWTH PLATE OF LONG BONES OF THE OFFSPRING WHEN GIVEN DURING PREGNANCY IN RAT MODEL
Authors: Umbreen Faiza , Qamar Khadija , Shaukat Sadia , Khan Maimoona , Malik Sana , Ali Hussain 
Published: January 2022

Objective: To evaluate histologically the deposition of iron in the epiphyseal cartilage of offspring’s of dams given iron supplementation during pregnancy and lactation in rat model.
Study Design: Laboratory based experimental study.
Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi and National Institute of Health (NIH) Islamabad, from Mar to Nov 2016.
Methodology: In this study, 16 female and 4 male adult rats were chosen for breading. After confirmation of pregnancy, pregnant rats were separated in two groups. One group was given oral iron supplementation for four weeks till delivery and half of the pups fed by mothers who were given iron during lactation. The other group was kept on normal lab diet. Deposition of iron in the epiphyseal cartilage of newborn rats after four weeks was evaluated histologically in pups.
Results: Iron deposition was maximum in group C i.e. 1.30 ± 0.48; in group B it was 0.20 ± 0.44. Statistically significant iron deposition (p<0.001) was observed in the growth plate of off springs when mothers were given iron supplements during pregnancy and lactation.
Conclusion: Present study proves that injudicious iron supplementation through pregnancy results in deposition of iron in epiphyseal growth plate of the fetus and it can have damaging effects on bones of fetus.
ASSOCIATION OF STRESS LEVEL WITH GENDER, SEMESTER OF STUDY AND CLINICAL PRACTICE IN UNDERGRADUATE PHYSICAL THERAPY STUDENTS: A CROSS SECTIONAL SURVEY
Authors: Ashraf Hafiza Sana , Sohail Maria , Tanveer Fahad , Farooq Haris , Masood Haleema 
Published: January 2022

Objective: To find association of stress level with gender, semester of study and clinical practice in undergraduate physical therapy students.
Study Design: Cross sectional observational survey.
Place and Duration of Study: Superior University, University of Management and Technology, University of Lahore, Lahore Medical and Dental College and Imperial University, from Apr to Jul 2019.
Methodology: Study was conducted on 358 students of physical therapy. Non-probability purposive sampling technique was used for data collection. Standard student Stress Inventory scale was used for the measurement of stress among students.
Results: Mean age of all the students in this study was 21.26 ± 1.997 with minimum of 18 years and with maximum of 25 years. There were 254 (70.9%) female students and 104 (29.1%) male students who participated in the study. Results showed 14.15% “Mild Stress”, 58.44% “Moderate Stress” and 27.4% “Severe Stress” in “Pre-Clinical Stage (1st - 4th semester)”. Chi-square test described a p-value of <0.001 (less than alpha level, α=0.05) for gender, semester of study and clinical practice which showed a strong association among these variables and students’ stress level.
Conclusion: Stress levels were more significant in females than males. “Severe Stress” was more prominent in ninth semester, “Moderate Stress” was more prevalent in third semester students and “Mild Stress” was highly present in sixth semester. Level of stress was more worthy of attention in “Pre-Clinical” students who were not doing any clinical practice.
HISTOLOGICAL CONSEQUENCES OF CONSUMPTION OF ENERGY DRINK ON RENAL TUBULES
Authors: Rasheed Ammara , Aslam Imtiaz , Tafweez Raafea , Bashir Kiani Muhammad Rizwan , Ameer Muhammad Kamran , Saeed Arslan Akbar 
Published: January 2022

Objective: To investigate the outcomes of energy drink on renal tubules of albino rats.
Study Design: Laboratory-based experimental study.
Place and Duration of Study: King Edward Medical University, Lahore from Aug 2018 to Dec 2019.
Methodology: Group A and B were experimental groups received 1.5ml/kg and 2.2ml/kg body weight of energy drink, respectively. Group C received 1ml/kg body weight of distilled water. Comparison among groups was made by applying One-Way ANOVA for quantitative variables. Tukey’ test was used for post hoc analysis. For qualitative variables, chi-square test was applied to make comparison among groups
Results: The mean initial and final weight of animals was around 152.7 ± 5.3g and 171.9 ± 5.1g, respectively. The mean paired kidney weight, relative tissue weight index, length and width of kidneys for all three groups were found insignificant. Microscopic examination showed tubular vacuolization in groups A and B showing p-value of 0.027.
Conclusion: Consumption of energy drinks results in histopathological injury of epithelial cells of renal tubules.
FREQUENCY OF INCREASED PLASMA C-PEPTIDE LEVELS IN COLORECTAL CANCER PATIENTS
Authors: Saleem Muhammad Hasan , Nisar Shazia , Saleem Muhammad Zulqurnain , Saleem Husnain , Mukhtar Shoaib , Anjum Muhammad 
Published: January 2022

Objective: To assess the increased frequency of serum C-peptide levels in patients of colorectal carcinoma.
Study Design: Cross sectional study.
Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from Jul 2018 to Jan 2019.
Methodology: A total of 100 cases of colorectal carcinoma were enrolled. Blood samples were obtained to assess C-peptide level. The C-peptide serum concentrations were deliberate through the Cobas 6000 by using the electro-chemi-luminescence immunoassay (ECLIA) method. If level of C-peptide was >2 pmol/mL, then it was noted.
Results: The mean age of all patients was 58.3 ± 5.4 years. There was a total of 136 (68%) females and 64 (32%) were males. The mean BMI of patients was 28.96 ± 12.31 kg/m2. The family history of colorectal carcinoma was positive in 6 (6%) cases. The mean C-peptide level was 4.55 ± 2.37 pmol/L. There were 33 (33%) patients with raised C-peptide level while 67 (67%) had normal c-peptide level.
Conclusion: It is concluded that increased C-peptide level is high in patients with colorectal cancer.
Impact of Music Intervention (Listening to Indian Classical Music) on Mental Wellbeing during COVID-19 Pandemic
Authors: Mukherjee Roan 
Published: January 2022

Background: Reports show that mental wellbeing may be negatively affected by the COVID-19 pandemic. The ragas of Indian classical music are believed to have therapeutic effects. This study was done to investigate the impact of an Indian raga on mental wellbeing during the COVID-19 pandemic. Materials and Methods: It was a one-group before-after design study. A total of 45 adult subjects of Kolkata, recruited online, using convenience sampling during the lockdown, underwent a pre-test via Google forms using Warwick-Edinburg Mental Wellbeing Scale (WEMWBS) to evaluate mental wellbeing before the administration of music intervention. After two weeks of music intervention, that consisted of passively listening to raga Hamsadhwani, a post-test using the same scale and the same medium was done. Results: The results showed that the post-test mean of the total score 51.1 (SD = 3.9) of WEMWBS was significantly (p< 0.001) higher than the pre-test mean of the total score 30.9 (SD = 4.6). The same trend was reflected by the mean difference pertaining to all of the components of WEMWBS. Conclusion: It was concluded that raga Hamsadhwani may be effective in improving mental wellbeing in a pandemic situation. There is a need to do more work by improvising the research design employed in the present study. This will help to interpret more accurately and more meaningfully the effects of Indian raga music on mental wellbeing.
Tinjauan Kemanan Proses Produksi Handsanitizer FTI-UMI
Authors: Arman Muh , Afrianti Afrianti , Maghfirah Ayudia 
Published: January 2022

Di Indonesia penyebaran virus covid-19 telah meresahkan masyarakat khususnya di kota Makassar. Sejak munculnya virus covid-19, masyarakat kini kesulitan untuk menemukan antiseptik seperti handsanitizer. Berdasarkan latar pendidikan yang sedang kami jalani. Kami berinisiatif untuk membuat handsanitizer, dengan tujuan untuk membantu masyarakat mendapatkan handsanitizer yang aman digunakan sehari-hari. Pencegahan penyebaran bakteri, virus dan jamur yang paling tepat adalah dengan mencuci tangan menggunakan sabun dan air yang mengalir. Tetapi perkembangan masyarakat yang modern menuntut manusia untuk selalu bergerak cepat dan menggunakan waktu seefisien mungkin, handsanitizer merupakan produk pilihan masyarakat saat ini, karena mudah dibawa kemana-mana dan mudah didapatkan(Walidah & Supriyanta, 2014). Pertama-tama yang kita lakukan adalah menyiapkan alat dan bahan. Kemudian mencampurkan aloe vera dan alkohol 70% dengan perbandingan 1:7 ke dalam gelas piala, selanjutnya mencampurkan aloe vera dengan alkohol lalu menambahkan esensial oil sebanyak 50 ml. kemudian mengaduknya selama 30 menit. Pembuatan hand sanitizer ini menggunakan bahan alkohol 70% dengan gel aloe vera dengan penambahan ekstrak kulit jeruk manis (Citrus x sinensis). Bahan yang digunakan dari handsanitizer adalah bahan-bahan yang alami sehingga aman untuk digunakan, bahkan alkohol yang digunakan dapat di antisipasi dengan penambahan aloe vera yang digunakan untuk memberikan nutrisi pada kulit. Serta esensial oil dari bahan alami yaitu kulit jeruk manis.