bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analysis of Defect Detection on Steel Strip Surface Using Modified Yolo V5
Authors: G Deepti Raj , B Prabadevi 
Published: July 2022

Abstract
Defects in any type of material do lessen the strength and will diminish the service life which in-turn affects the quality. Steel surface images with broad scale variance and complicated background lessens the high quality and productiveness. In steel surface images detection, there are hitches of small target sizes and imprecise features that causes incorrect and ignored detection. Nevertheless, these problems can be avoided with the aid of inspecting the defects earlier than processing with accurate and automated object detection algorithms. YOLOv5, a fine tuned learning model is evaluated on available steel strip datasets, which solves identification and detection problems in industrial scenario. The current YOLOv5 research focus on improving accuracy on defect classification and detection speed however there’s no distinct records on algorithm execution time and size. This study focus on YOLOv5 model with induced GHOST and TRANSFORMER modules. Through the new modules, we are looking to reduce the size of the algorithm, number of parameters and number of GFLOPS. By these changes this model may be deployed easily on mobile, embedded devices for detection of small, easily confused defects.
SOX17: a highly sensitive and specific marker for ovarian and endometrial carcinomas
Authors: Zhang Xudong , Yao Jun , Niu Na , Li Xiaoran , Liu Yan , Huo Lei , Wang Huamin , Bell Diana , Sood Anil , Lawson Barrett , Ramalingam Preetha , Euscher Elizabeth , Malpica Anais , Sahin Aysegul , Ding Qingqing , Liu Jinsong 
Published: July 2022

Abstract
A major challenge in diagnostic pathology is to identify sensitive and specific markers for tumor origin. Although PAX8 is the most widely used marker for gynecological tumors, it is not entirely specific, which makes it difficult to determine the origin of some tumors with high confidence. Through mining The Cancer Genome Atlas mRNA expression profile data, we identified SOX17 as a potential specific marker at the mRNA level for gynecological tumors. To test SOX17 expression at the protein level, we performed immunochemical staining in a large cohort of ovarian and endometrial cancer cases (n = 402) together with a large cohort of solid tumors from other organs (n = 1269). Similar to PAX8, SOX17 was highly expressed in all subtypes of ovarian carcinoma (97.5% for SOX17 vs. 97% for PAX8 in serous, 90% vs. 90% in endometrioid, and 100% vs. 100% in clear cell and transitional cell types) except for mucinous carcinoma (0% vs 27%), and also highly expressed in endometrial endometrioid carcinoma (88% vs 84%). However, SOX17 was completely negative in thyroid carcinoma and renal cell carcinoma, whereas PAX8 expression was high (86% and 85%, respectively). In addition, SOX17 had no expression in breast carcinoma, lung carcinoma, pancreatic adenocarcinoma, colonic and gastric adenocarcinomas, salivary ductal carcinoma, hepatocellular carcinoma, and cholangiocarcinoma. Our data indicate that SOX17 is not only a sensitive but also a specific marker for the origin of ovarian and endometrial carcinomas.
Identifying SOX17 as a sensitive and specific marker for ovarian and endometrial tumors
Authors: Shaker Nada , Chen Wei , Sinclair William , Parwani Anil , Li Zaibo 
Published: July 2022

Abstract
Like PAX8, SOX17 was recently identified as a master transcription factor of ovarian cancer based on RNA sequencing data. We explored SOX17’s utility in diagnosing ovarian tumors and other gynecologic tumors. We systematically evaluated SOX17 expression on tissue microarrays from 398 ovarian tumors of various types, 93 endometrial carcinomas, 80 cervical carcinomas, and 1,055 non-gynecologic carcinomas from kidney, thyroid, breast, colon, bladder, liver and bile duct. In addition, SOX17 expression was evaluated on whole tissue sections from 60 gynecologic carcinomas and 10 angiosarcomas. The results demonstrated that SOX17 was highly expressed in most ovarian and endometrial tumors with strong intensity, but unlike PAX8, it was predominately negative in other tested tumor types including kidney and thyroid tumors. Specifically, SOX17 was highly expressed in the following types of ovarian tumors: serous carcinoma, clear cell carcinoma, endometrioid carcinoma, and germ cell tumors. SOX17 was mostly negative in mucinous carcinoma and sex cord stromal tumors. In addition, SOX17 was expressed in vascular endothelial cells and positive in all tested angiosarcomas. In summary, our results demonstrate that SOX17 is a sensitive and specific marker for ovarian non-mucinous carcinomas and endometrial carcinomas with a comparable sensitivity, but better specificity than PAX8. Furthermore, SOX17’s positivity in endothelial cells serves as an internal positive control, making it an excellent marker.
Observer-based Controller Design for Semi-Markov Jump Systems With Multiple Disturbances and Input Saturation
Authors: Ren Shuaishuai , Wei Yunliang , Zhang Qincheng 
Published: July 2022

Abstract
This paper discusses the observer-based H ∞ control problem for semi-Markov jump systems (S-MJSs) with generally uncertain transition rates (TRs) and input saturation, where the S-MJSs also consider H 2 -norm bounded disturbances and exosystem generated disturbances. First, the sufficient conditions for the local stochastic stability of the closed-loop system are given. Then, a full-order observer is designed to observe both the system state and external disturbance. Based on its estimated values, the composite controller is constructed to guarantee the system performance, and solvability conditions are proposed to ensure the closed-loop system to be the local stochastic stability with H ∞ performance level. Further, the maximum estimation of the attraction domain is given by an optimization problem. Finally, the effectiveness of the proposed method is verified by numerical example.
Host-delivered RNAi mediated silencing of HaAce1, encoding the major isoform of acetylcholinesterase, imparts resistance against the polyphagous insect-pest, Helicoverpa armigera
Authors: Jaiswal Sandeep , K Venkat Raman , Saini Ravi Prakash , Tilgam Jyotsana , Gurusamy Dhandapani , Sreevat Rohini , Pattanayak Debasis 
Published: July 2022

Abstract
The polyphagous insect pest, Helicoverpa armigera, is a detriment to crop productivity. Host-delivered RNAi has emerged as a potential tool to complement Bt technology for controlling insect pest menace. In this study transgenic tobacco ( Nicotiana tabacum L.; cv. Petit Havana) plants expressing dsRNA targeting the H. armigera gene, HaAce1 , encoding the major isoform of acetylcholinesterase, were developed. A 643 nucleotide RT-PCR amplified HaAce1 cDNA fragment was ligated in sense and antisense orientation intervened by GBSS intron to develop an inverted repeat (IR) gene construct. The HaAce1 IR gene construct (IR- Ace1 ) under the transcriptional control of CaMV 35S promoter and NOS terminator was used for Agrobacterium -mediated transformation of tobacco leaf disc explants. Fourteen HaAce1- hpRNA tobacco transgenic lines were obtained after screening of 31 putative transformants by PCR and RT-PCR. Five HaAce1- hpRNA tobacco transgenic lines demonstrated high level of resistance against H. armigera larvae based on detached leaf insect bioassay. These selected five tobacco transgenic lines carried two to four copies of the transgene . Generation of HaAce1 -specific siRNA was detected in these tobacco transgenic lines. Semi-quantitative PCR revealed many-fold reductions in the steady-state level of HaAce1 mRNA in larvae fed on leaves of the selected transgenic tobacco lines compared to that in control tobacco leaf-fed larvae. Our findings demonstrate that the host delivered dsRNA targeting Ace1 gene could be a promising strategy for controlling insect pest menace in crops.
Olmesartan alleviates symptoms of chronic fatigue syndrome in mice
Authors: Saqulain Sadique , Sharma Rahul Kumar , Kushwah Ajay Singh , Kumar Manish 
Published: July 2022

Abstract
Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is a lifestyle-related ailment that affects physical and mental abilities. The etiology is largelyunidentified but there are certain multifactorial mechanisms responsible such as mitochondrial aerobic pathways aberrations, hypothalamic-pituitary-adrenal (HPA) axis deregulation, immune hyperactivation, free radicals, pathogen infections, and central neurohumoral alterations. Olmesartan is an antihypertensive drugthat acts on the angiotensin 1 (AT1) receptor. The present research evaluatedthe efficiency of OlmesartanagainstCFS. CFSwas induced by lipopolysaccharide (LPS, 1mg/kg,i.p.) once on day 1 trailed by a forced swim (10minutes)continued for 21 consecutive times once each day. Olmesartan (1and 3mg/kg,p.o.) and dexamethasone (standard drug, 0.5mg/kg, i.p.) were given from the 1st to 21stday. Immobility time was noted in the forced swim test (FST). Elevated plus maze, raised zero maze, and open field tests were employed to assess animal behavior.Plasma glucose and cortisol, lipid peroxidation, and GSH levels were determined in the whole brain. LPS and repeated forced swim sessions instigated symptoms of CFS such as memory deficit and depression and anxiety-like symptoms. Findings suggested that Olmesartan shortened the immobility period of mice against CFS in FST. Olmesartan reduced memory deficits, increased ambulation, and exerted an anxiolytic effect. Olmesartan treatment reduced blood cortisol levels, brain TBARS, and enhanced brain GSHin the CFS mouse model. Hence, Olmesartan may prove to be an effective treatment for CFS and related behavioral discrepancies.
Perceived home and host country institutional environment pressures by bilateral development cooperation agency's constituents
Authors: Fushimi Katsutoshi 
Published: July 2022

Abstract
Public organisations have been rarely the subjects of neo-institutional research. Intra-organisational behaviour has been under-researched, too. This study examined how four distinct groups of bilateral development cooperation agency (BDCA) staff perceive institutional environment pressures from home and host countries. 131 valid responses obtained through an online survey were analysed. Both the HQ and the OOs staff identically felt a powerful home country accountability pressure. This tendency is prominent for management staff. The test results, as seen through the lens of a neo-institutional perspective, suggest that OOs staff prioritise answerability to home country stakeholders over that to host country stakeholders.
Is there a correlation between positive antiphospholipid antibodies and renal involvement in IgA vasculitis?
Authors: Yeganeh Mehrnoush Hassas , Sinaei Reza , Yaraghi Aye , Rahmani Khosro , Parvaneh Vadood Javadi , Shiari Reza , Hosseinzadeh Hamid 
Published: July 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Hybrid chitosan/CaO-based nanocomposites doped with plant extracts from Azadirachta indica and Melia azedarach: evaluation of antibacterial and antibiofilm activities
Authors: Paunova-Krasteva Tsvetelina , Hemdan Bahaa A. , Dimitrova Petya D. , Damyanova Tsvetozara , El-Feky Amal M. , Elbatanony Marwa M. , Stoitsova Stoyanka , El-Liethy Mohamed Azab , El-Taweel Gamila E. , Nahrawy Amany M. El 
Published: July 2022

Abstract
This study examines substances from plant leaves of Azadirachta indica and Melia azedarach extracted with methanol (80%) and then successively fractionated with increasing gradient polarity solvents. The methanol extract from the two plant leaves was selected to be incorporated with nanocomposites because of their high antimicrobial activities. HPLC analysis was performed for the determination of total phenolics and flavonoids. LC-ESI-MS positive ion acquisition mode revealed the presence of four main chemical classes; limonoids, triterpenes, fatty acids, and phenolics. Sol-gel processes were adapted to prepare CaO/chitosan composite loaded with the methanol extract of the two plant leaves, acting as innovative antibacterial agents. The fabricated nanocomposites were characterized by XRD, TEM, SEM, and FT-IR methods. Minimal bactericidal concentrations (MBC) were established by agar plating using bacteria treated with MIC and at least 2 concentrations double-higher than the MIC. Biofilm was cultivated in the presence of sub-MICs of the extracts and the nanocomposites, followed by quantification with the crystal violet assay. The examined chitosan-CaO-based hybrid nanocomposites loaded with the methanol fractions from the leaves of A. indica and M. azedarach had an excellent performance as biofilm inhibitors. This indicates their good potential for biomedical applications.
Acceptability and expected changes in parental practices after an online behavioural parent program for ADHD during the Covid-19 pandemic
Authors: Rahaly Myriam , Fongaro Erica , Franc Nathalie , Nesensohn Jessica , Purper-Ouakil Diane , Kerbage Hala 
Published: July 2022

Abstract
Background: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents, characterized by attention deficit, hyperactivity, and impulsivity. Treatments for this population should be multidisciplinary and must be initiated as soon as possible. Non-pharmacological interventions for ADHD include psychoeducation, parent behavioural training programs and school interventions and accommodations. In response to the COVID-19 pandemic, we developed an online version of a combined psychoeducation and behavioural training program to facilitate access to mental health treatment and ensure continuity of care. The study assessed the acceptability of this online parent training program, among parents and/or caretakers of children and adolescents with ADHD. Methods: The program consisted of 10 online sessions over the course of 2 consecutive days (5 sessions a day). Satisfaction, usefulness and general comments about the program were assessed with open-ended questions and visual-analogous scales. Parents/caretakers’ use of strategies to manage behavioural problems was assessed using the Parenting and Family Adjustment Scales. Results: A total of 206 parents participated in the online program and 175 of them completed the evaluation. Overall, participants were satisfied with the content of the program and found it beneficial for their child. The engagement was high and no major obstacles were identified to participation, except some internet connection issues. More than half of participants had already used some of the strategies included in the program. Despite this, some difficulties in implementing new strategies were observed. Conclusions: Our study contributes to the growing body of papers evaluating online behavioral training program to improve their efficacy and content. With these measures, we hope to improve engagement in online psychoeducation and behavioural therapy programs. Future research evaluating online behavioural training programs should focus on ways to make them more accessible and adaptable to families’ obstacles.
Risk assessment and pre-alarm on invasive peculiarities of ornamental grasses to the urban greening routine
Authors: Chao Chen , Wen-Jun Teng , Hui Zhang , Ju-Ying Wu , Scullion John , Bye Ruby 
Published: July 2022

Abstract
Two risk assessment protocols, the Weed Risk Assessment for Central Europe (WG-WRA) and the Australian Weed Risk Assessment (WRA), were adapted to evaluate the invasion risk of eighty-two ornamental grasses. Meanwhile, some particular characteristics of these ornamental grasses, like ornamental value, biological and ecological characteristics were highlighted and assessed for their potential risk by field observations and method of expert ranking. There was a positive correlation between scores derived from the two risk protocols, though WRA was considered to be more acceptable than WG-WRA according to the analysis of ornamental grasses. Anyhow, well-cultivated cultivars were less-efficiently predicted by the two risk protocols compared with the protospecies in the study, as well as some outliers with higher fecundity. In details, the risk classification differed: risk categorization using the WG-WRA protocol allocated high and moderate risk to 81.1% of 45 native grasses, yet only 22.2% of 37 alien species. Assessment using the WRA protocol scored 91.5% of the studied grasses to pose invasion risk following a diverse criterion, of which 97.3% were for native species and 86.7% for alien species. On details, ranked scores of biological and ecological characteristics of ornamental grasses highlighted herein were correlated with risk scores, although the significance of these relationships varied; while ornamental value had a weak relationship to the risk scores. In addition, some features peculiar to ornamental grasses relating to their invasive tendency are presented that most (72.0%) of the alien ornamental grasses exhibit perenniality, intentionally introduced from the Americas and Europe, and to a lesser extent from Asia, Africa, and Australia. In general, the ornamentals with high fecundity and adaptability presented a higher risk of invasion, while well-domesticated cultivars or hybrid species with high aesthetic scores yet relatively low levels of fecundity and adaptability, presenting a low invasion risk. Thus, special attention should be paid to the invasive characteristics of ornamental grasses to mitigate risks to agriculture and local ecosystems and also some amendments are needed to improve the risk assessment protocols at some certain case or even a larger scale during application in projects of urban greening and environmental restoration.
Estimation and feasibility of correction modelling for mother-reported child height and weight at 2 years using data from the Australian CHAT trial
Authors: Cheng Yan , Xu Huilan , Rissel Chris , Phongsavan Philayrath , Buchanan Limin , Taki Sarah , Hayes Alison , Baur Louise A , Wen Li Ming 
Published: July 2022

Abstract
Background
Correction modelling using reported BMI values has been employed in adolescent and adult populations to improve the accuracy of self-reporting.
Objective
This study aimed to evaluate the feasibility of establishing correction modelling for mother-reported child height and weight at 2 years using data from an Australian trial in 2019.
Methods
Correction modelling for BMI was conducted using mother-reported and objectively measured height and weight of 2-year-olds. Mother-reported height, weight and BMI values of 2-year-old children were adjusted based on objectively measured anthropometric data using linear regression models. ‘Direct’ and ‘indirect’ corrections were applied to the correction of BMI values. We defined the direct collection as using corrected BMI values that were predicted directly by the model and indirect correction as using corrected weight and height values to calculate corrected BMI values.
Results
Corrected BMI values via the indirect correction showed higher sensitivity or similar specificity in predicting overweight status, compared to the direct correction, and also showed higher agreement with measured values compared to the mother-reported measures.
Conclusions
Corrected self-reported measures via an indirect correction had a better accuracy and agreement with the objectively measured data in the BMI values and classification of overweight, compared to the mother-reported values.
Functional constipation is associated with a decline in word recognition 2 years later in community-dwelling older adults: The Korean Frailty and Aging Cohort Study
Authors: Jang Hoseok , Kim Sunyoung , Kim Byungsung , Kim Miji , Jung Jaehoon , Won Chang Won 
Published: July 2022

Abstract
Background: Constipation is one of the most common health problems among the elderly, and cognitive impairment is also a major health problem among the elderly. Identifying risk factors for cognitive impairment is important to prevent many cognitive disorders. Though studies on cognitive decline in patients with Parkinson’s disease are available, no study has explored the predictive effect of functional constipation on cognitive decline in non-Parkinson’s elderly individuals. This study aimed to determine the association between constipation and cognitive decline in community-dwelling older adults. Methods: This is a 2-year longitudinal analysis of cohort study data, including 851 community-dwellers as participants at the baseline survey who took part in the Korean Frailty and Aging Cohort Study and completed a follow-up survey. A neuropsychological test (CERAD-K, the Consortium to Establish a Registry for Alzheimer's Disease Assessment Battery) and the Korean version of the Frontal Assessment Battery were used to evaluate comprehensive cognitive function. Functional constipation was defined according to the ROME IV criteria. Analysis of covariance was used to identify the association between functional constipation and cognitive decline statistically.Results: Among the 851 participants, 8.9% had functional constipation. The mean age of the functional constipation group (78.6 ± 3.9) was higher than that of the non-constipation group (77.5 ± 3.8). Patients in the functional constipation group were more likely to have low physical activity (15.8% vs. 8.8%), polypharmacy (61.8% vs. 45.5%), and depression (30.3% vs. 17.4%). After adjusting for potential confounding factors, including age, low physical activity, polypharmacy, type 2 diabetes mellitus, depressive disorder, and baseline cognitive function test score, the mean changes in word recognition test scores from 2018 to 2020 were -0.071 and -0.524 in the no-constipation and constipation groups, respectively (P=0.009). Changes in other cognitive function tests showed a tendency to be lower in the constipation group (memory -0.138 vs. -0.489, recall -0.296 vs. -0.407, digit span -0.248 vs. -0.379, frontal assessment battery 0.281 vs. 0.12, trail making test 0.143 vs. 5.38), but were not significantly different.Conclusions: Functional constipation at baseline was associated with a decline in word recognition after two years.