bluuebunny/crossref_metadata_2025_split huggingface dataset:
The possible effect of lactoferrin on the epigenetic characteristics of early mammalian embryos exposed to bisphenol A
Authors: Postnikova Liubov A. , Patkin Eugene L. 
Published: April 2022

AbstractBackgroundThe main objective of this review was to state a hypothetical mechanism of the antitoxic effect of lactoferrin (Lf) on embryos exposed to bisphenol A (BPA). On this basis, it is possible to suggest Lf as a potential protective health component before conception upon toxic effects and viral infections.MethodsThe narrative review was performed using systematic review methods to identify relevant literature. The resources required for this study were obtained by searching the electronic database PubMed (MEDLINE). Articles were searched using the keywords “BPA,” “lactoferrin,” “DNA‐methylation,” “epigenetic,” “mammals,” “human,” and “mouse.” The inclusion criteria were as follows: (a) primary or original research; (b) study of epigenetic modification; and (c) study focuses on early mammalian development.ResultsPresented data demonstrate that Lf can modulate epigenetical characteristic, such as DNA methylation and reactive oxygen species (ROS), and, thereby, may serve as a potential readily available pharmaceutical product.ConclusionSuggested hypothesis is based on the important interrelated role of changes in epigenetic modifications and oxidative stress in early embryogenesis under the influence of BPA and virus infection as a cause of the development of pathologies in the adult organism.
Motility, viscosity and field: A portrayal of migrant teachers' professional mobility and ethical conflicts in American and Australian faith‐based schools
Authors: Finefter‐Rosenbluh Ilana 
Published: April 2022

AbstractInternational migration is attaining new records, diversifying nations' cultural–social landscapes. The number of international migrants is estimated to be about 272 million globally, with nearly two‐thirds being labour migrants, surpassing historic projections. Concomitantly, migrant teachers are becoming more prevalent in educational markets; spaces that may serve as institutional vehicles promoting social cohesion and tolerance. Acknowledging that such spaces have an increasing share of faith‐based schools—settings that foreground particular groups' cultural and social values—this critical analysis seeks to identify how migrant teachers' aspirations are shaped and ethically negotiated in seemingly exclusive educational sites. Drawing upon migrant teacher interviews from American and Australian faith‐based schools, and utilising concepts of motility and institutional viscosity, this paper captures the schools' ‘viscous’ conditions and complex facilitation through which educators professionally move and ethically navigate their practice. Bourdieu's thinking tools of field, habitus, capital and symbolic violence provided a supplementary theoretical framework that draws attention to the evolving discourse of the subordinate ‘invisible foreign educator’ in the faith‐based educational setting. The paper portrays strategies of initial institutional welcoming; enabling migrant educators a smooth spatial mobility into the field but challenging them to work against their social mobility aspirations. It illustrates the educators' failed attempts to negotiate intra‐institutional transitions; experiencing feelings of trepidation about future professional moves and ethical conflicts between their obligation to adhere to institutional procedures and commitment to operate from an ethic of care. The paper argues for education policies that enable motility over time and empower ethical skilled migration.
Prevalence of migraine headaches and their impact on the academic performance of Sudanese medical students using ID‐Migraine test as a screening tool: A cross‐sectional study
Authors: Osman Ali Moaid Mohamed , Abbasher Hussien Mohamed Ahmed Khabab , Omer Mohammed Eltahier Abdalla 
Published: April 2022

AbstractBackgroundMigraine—and episodic headache—is one of the most common types of primary headache. Migraine is considered a serious health problem that affects the quality of life. During university life, students often report increased levels of stress, depression, anxiety, and irregular sleep, all of which are associated with migraines. Our aim was to determine the prevalence of migraine headaches among medical campus students at the University of Khartoum, Sudan. Based on available data, migraine is on the rise in both general populations as well as in university students.MethodsThis is a cross‐sectional study. The study population was composed of students registered to the Faculty of Medicine, Dentistry, and Pharmacy at Khartoum University in the academic years of 2020–2021. Out of these, 318 of them accepted to participate. Participants who had two or more headaches in the last 3 months formed the headache group. Afterwards, two preliminary questions were applied to the headache group and participants with at least one affirmative response were asked to perform the validated ID‐Migraine™ test.ResultsThe mean age of 318 students participating in the study was 19.23 ± 1.84 (17–39 years), with adolescents:adult ratio being 2.5:1. A total of 1613 students (43.7%) had at least two headaches in the last 3 months. Migraine‐type headache was detected in 266 subjects (7.2%) based on the ID‐Migraine™ test. Of the migraine group, 72 were male (27.1%) and 194 were female (72.9%). There was no significant difference in migraine prevalence between adolescent and adult age groups.ConclusionsWith prevalence similar to adults, primary care physicians should be aware of the probability of migraine headaches in university students in order to maintain a successful school performance.
The discourse of being ‘triggered’: Uses and meanings among counselling students
Authors: Bonilla Sara , Natarajan Madison , Koven Julie , White Lindsey , Lamb Sharon 
Published: April 2022

AbstractDespite the initial understanding of the word ‘triggered’ as relating to the clinical phenomenon of post‐traumatic stress disorder (PTSD), this language has become a common part of the vernacular today, used by many people to apply to a wide variety of experiences and events. Counselling students are particularly sensitised to trauma, as well as identity politics, and are familiar with trigger warnings at college. They themselves have experienced trauma at high rates. Therefore, we were interested to understand how they might be using the word and interpreting the experience of being ‘triggered’, whether different sources of being triggered are related to emotional reactions, and whether a discourse analysis might indicate how and why the term has become useful and for what other experiences it might be serving as a stand‐in. In this mixed‐methods study, 79 counselling students from around the country shared their definitions and experiences of being ‘triggered’. Participants completed surveys and wrote narratives, which, via thematic qualitative analysis, were coded into five themes. The quantitative analysis focused on the relationship of feelings to themes and the relationship between anger suppression and coping with each theme. Discourse analysis explored how individuals wrote about responsibility and anger. It was discovered that those who wrote about being triggered from a past sexual assault did not discuss anger, nor the responsibility of others to protect them (as those who wrote about microaggressions did), but positioned themselves as overreactors. Results are discussed with regard to training and practice.
Accuracy of echocardiographic estimations of right heart pressures in adult heart transplant recipients
Authors: Sridharan Aadhavi , Dehn Monica M. , Cooper Craig , Madineedi Vidya S. , Ordway Linda J. , DeNofrio David , Patel Ayan R. 
Published: April 2022

AbstractBackgroundAccurate assessment of right atrial pressure (RAP) and pulmonary artery systolic pressure (PASP) is critical in the management of heart transplant recipients. The accuracy of echocardiography in estimating these pressures has been debated.ObjectiveTo assess the correlation and agreement between echocardiographic estimations of right heart pressures with those of respective invasive hemodynamic measurements by right heart catheterization (RHC) in adult heart transplant recipients.MethodsThis is a prospective evaluation of 84 unique measurements from heart transplant recipients who underwent RHC followed by standard echocardiographic evaluation within 159 ± 64 min with no intervening medication changes. The relationship between noninvasive pressure estimations and invasive hemodynamic measurements was examined.ResultsMean RAP was 7 ± 5 mmHg and mean PASP was 33 ± 8 mmHg by RHC. There was no significant correlation between echocardiographic estimation of RAP and invasive RAP (Spearman's rho = −0.05, p = .7), and no significant agreement between these two variables (weighted kappa = −0.1). There was a modest correlation between echocardiographic estimation of PASP and invasive PASP (r = .39, p = .002). Bland‐Altman analysis showed a mean bias of 2.1 ± 9 mmHg (limits of agreement = −15 to 20 mmHg).ConclusionIn heart transplant recipients, there is no significant correlation or agreement between echocardiographic RAP estimation and invasively determined RAP. Noninvasive PASP estimation correlates significantly but modestly with invasively measured PASP. Further refinement of echocardiographic methods for assessment of RAP is warranted in this unique patient population.
Human gut microbiome in human immunodeficiency virus and acquired immunodeficiency syndrome‐related diseases: Clinically relevant observations
Authors: Higgs Jordan A. , Seely Kevin D. , Brooks Amanda E. 
Published: April 2022

AbstractThe implications of recent discoveries pertaining to immune‐mediated disease and the human gut microbiome are vast. In a symbiotic relationship, the immune system modulates the maintenance of host‐microbe normobiosis, and the gut microbiome plays a critical role in developing and maintaining the host's innate and adaptive immune systems. The cutting edge of microbiome research and personalized medicine targets the clinical application and exploitation of gut microbiota modulation in the setting of specific diseases. For example, prebiotic/probiotic supplementation, microbiome enhancing diets, and fecal microbiota transplant have been studied as potential ameliorative supplemental interventions to combined antiretroviral therapy (cART) in human immunodeficiency virus‐positive (HIV+) individuals. Furthermore, recent evidence shows a positive correlation between improved CD4+ cell counts in HIV+ individuals and improved gut microbiota profile after cART. We supplement this finding with data and supporting evidence from recent studies to aid in the clinical application of these findings in this commentary. Preliminary data support the consideration of the gut microbiota in the proactive management of HIV‐associated comorbidities.
Exploring disease interrelationships in patients with lymphatic disorders: A single center retrospective experience
Authors: Rockson Stanley G. , Zhou Xin , Zhao Lan , Hosseini Davood K. , Jiang Xinguo , Sweatt Andrew J. , Kim Dongeon , Tian Wen , Snyder Michael P. , Nicolls Mark R. 
Published: April 2022

AbstractBackgroundThe lymphatic contribution to the circulation is of paramount importance in regulating fluid homeostasis, immune cell trafficking/activation and lipid metabolism. In comparison to the blood vasculature, the impact of the lymphatics has been underappreciated, both in health and disease, likely due to a less well‐delineated anatomy and function. Emerging data suggest that lymphatic dysfunction can be pivotal in the initiation and development of a variety of diseases across broad organ systems. Understanding the clinical associations between lymphatic dysfunction and non‐lymphatic morbidity provides valuable evidence for future investigations and may foster the discovery of novel biomarkers and therapies.MethodsWe retrospectively analysed the electronic medical records of 724 patients referred to the Stanford Center for Lymphatic and Venous Disorders. Patients with an established lymphatic diagnosis were assigned to groups of secondary lymphoedema, lipoedema or primary lymphovascular disease. Individuals found to have no lymphatic disorder were served as the non‐lymphatic controls. The prevalence of comorbid conditions was enumerated. Pairwise co‐occurrence pattern analyses, validated by Jaccard similarity tests, was utilised to investigate disease–disease interrelationships.ResultsComorbidity analyses underscored the expected relationship between the presence of secondary lymphoedema and those diseases that damage the lymphatics. Cardiovascular conditions were common in all lymphatic subgroups. Additionally, statistically significant alteration of disease–disease interrelationships was noted in all three lymphatic categories when compared to the control population.ConclusionsThe presence or absence of a lymphatic disease significantly influences disease interrelationships in the study cohorts. As a physiologic substrate, the lymphatic circulation may be an underappreciated participant in disease pathogenesis. These relationships warrant further, prospective scrutiny and study.
Extracellular vesicle‐packaged mitochondrial disturbing miRNA exacerbates cardiac injury during acute myocardial infarction
Authors: Sun Ping , Wang Chao , Mang Ge , Xu Xiangli , Fu Shuai , Chen Jianfeng , Wang Xiaoqi , Wang Weiwei , Li Hairu , Zhao Peng , Li Yifei , Chen Qi , Wang Naixin , Tong Zhonghua , Fu Xin , Lang Ying , Duan Shasha , Liu Dongmei , Zhang Maomao , Tian Jiawei 
Published: April 2022

AbstractMounting evidence suggests that extracellular vesicles (EVs) are effective communicators in biological signalling in cardiac physiology and pathology. However, the role of EVs in cardiac injury, particularly in ischemic myocardial scenarios, has not been fully elucidated. Here, we report that acute myocardial infarction (AMI)‐induced EVs can impair cardiomyocyte survival and exacerbate cardiac injury. EV‐encapsulated miR‐503, which is enriched during the early phase of AMI, is a critical molecule that mediates myocardial injury. Functional studies revealed that miR‐503 promoted cardiomyocyte death by directly binding to peroxisome proliferator‐activated receptor gamma coactivator‐1β (PGC‐1β) and a mitochondrial deacetylase, sirtuin 3 (SIRT3), thereby triggering mitochondrial metabolic dysfunction and cardiomyocyte death. Mechanistically, we identified endothelial cells as the primary source of miR‐503 in EVs after AMI. Hypoxia induced rapid H3K4 methylation of the promoter of the methyltransferase‐like 3 gene (METTL3) and resulted in its overexpression. METTL3 overexpression evokes N6‐methyladenosine (m6A)‐dependent miR‐503 biogenesis in endothelial cells. In summary, this study highlights a novel endogenous mechanism wherein EVs aggravate myocardial injury during the onset of AMI via endothelial cell‐secreted miR‐503 shuttling.
Endoscopic therapy for recurrent pancreatitis complicated with pancreatolithiasis in a case of annular pancreas
Authors: Mizutani Saori , Okano Naoki , Nakagawa Hiroki , Watanabe Koji , Yamada Yuto , Kimura Yusuke , Yoshimoto Kensuke , Iwasaki Susumu , Hara Seiichi , Takuma Kensuke , Kishimoto Yui , Ito Ken , Matsuda Takahisa , Igarashi Yoshinori 
Published: April 2022

AbstractAnnular pancreas is a congenital abnormality in which part of the pancreatic head completely or partially surrounds the duodenum in a ring‐like manner. The condition is thought to be an abnormality of the ventral pancreatic bud. While pancreatitis is a common complication of the annular pancreas, its recurrence may be prevented by improving the outflow of pancreatic juice. The present case report describes a 23‐year‐old woman who had been referred to our hospital for recurrent pancreatitis since childhood. An endoscopic incision was made on the orifice of the annular pancreas, after which pancreatitis of the annular pancreas did not recur for 6 years. The patient subsequently exhibited pancreatolithiasis in the dorsal pancreatic duct, which was successfully treated with endoscopic treatment. Endoscopic pancreatic sphincterotomy may prevent the recurrence of pancreatitis and avoid further surgical interventions by improving the flow of pancreatic juice.
Versatility of the Amino Group in Hydrazone‐Based Molecular and Supramolecular Systems
Authors: Betancourth Jolaine Galindo , Castaño Jorge A. , Visbal Renso , Chaur Manuel N. 
Published: April 2022

AbstractHydrazone‐based systems have been, and continue to be, widely studied in the field of supramolecular chemistry due to the chemical versatility of their triatomic C=N‐N structure, whose amino nitrogen commonly bears a methyl group or a hydrogen atom. Herein we review the conformational, configurational, and constitutional dynamics of these systems, focusing on the particularly important role of the N−H group of the hydrazone framework in each of those processes observed in molecular and supramolecular systems published in recent decades. Due to the enormous diversity of supramolecular architectures and molecular entities, the most representative synthetic methodologies to obtain them are described.
Limited prognostic value of pain duration in non‐specific neck pain patients seeking chiropractic care
Authors: Guillén David , Guekos Alexandros , Graf Nadia , Humphreys Barry Kim , Peterson Cynthia , Schweinhardt Petra 
Published: April 2022

AbstractBackgroundPain chronicity is considered an important prognostic factor for outcome. Here, it was investigated whether pain duration influences outcome when only chronic patients (pain >3 months) are considered. Secondary aims were to determine, in patients of any pain duration, how much variance in outcome is explained by pain duration and whether pain duration truly predicts outcomes, that is out‐of‐sample prediction in independent data.MethodsSecondary analysis of a cohort study of neck pain patients. Patients were assessed before start of treatment and at 1‐week, 1‐, 3‐, 6‐ and 12‐month follow‐up. Outcomes were patient global impression of change (PGIC) and percent change in patients' perceived pain intensity, rated on a numerical rating scale (NRS). Regression analyses (linear and logistic) and supervised machine learning were used to test the influence of pain duration on PGIC and percent NRS change at 1‐week, 1‐, 3‐, 6‐ and 12‐month follow‐up within sample and out‐of‐sample. Separate analyses were performed for the full sample (n = 720) and for chronic patients (n = 238) only.ResultsNo relationship between pain duration and outcome was found for chronic patients only. For the full sample, statistical relationships between pain duration and outcomes were observed at all tested follow‐up time points. However, the amount of variance in outcome explained by pain duration was low and no out‐of‐sample prediction was possible.ConclusionsPain duration did not emerge as an important predictor of outcome in this database of 720 neck pain patients receiving chiropractic treatment.Significance statementThe relatively large dataset of neck pain patients challenges the widely accepted wisdom that pain duration is an important predictor of pain outcomes and that very chronic patients might only have a small likelihood of getting better. It is postulated that these results are important for the attitude of the first encounter between healthcare professionals and chronic patients.
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder
Authors: Moog Maia , Baraban Scott C. 
Published: April 2022

AbstractCRISPR‐Cas9–generated zebrafish carrying a 12 base‐pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants provide an efficient preclinical platform to test antiseizure therapeutics. The present study was designed to test antiseizure medications approved for clinical use and two recently identified repurposed drugs with antiseizure activity. Larval homozygous stxbp1b zebrafish (4 days postfertilization (dpf)) were agarose‐embedded and monitored for electrographic seizure activity using a local field recording electrode placed in midbrain. Frequency of ictal‐like events was evaluated at baseline and following 45 min of continuous drug exposure (1 mM, bath application). Analysis was performed on coded files by an experimenter blinded to drug treatment and genotype. Phenytoin (PHT), valproate (VPA), ethosuximide (ESX), levetiracetam (LEV), and diazepam (DZP) had no effect on the ictal‐like event frequency in stxbp1b mutant zebrafish. Clemizole and trazodone decreased ictal‐like event frequency in stxbp1b mutant zebrafish by 80% and 83%, respectively. These results suggest that repurposed drugs with serotonin receptor–binding affinities could be effective antiseizure treatments. Clemizole and trazodone were previously identified in a larval zebrafish model for Dravet syndrome. Based primarily on these preclinical zebrafish studies, compassionate‐use and double‐blind clinical trials with both drugs have progressed. The present study extends this approach to a preclinical zebrafish model representing STXBP1 (syntaxin‐binding protein 1)‐related disorders and suggests that future clinical studies may be warranted.
Effects of Microplastic on the Population Dynamics of a Marine Copepod: Insights from a Laboratory Experiment and a Mechanistic Model
Authors: Everaert Gert , Vlaeminck Karel , Vandegehuchte Michiel B. , Janssen Colin R. 
Published: April 2022

Abstract
Microplastic is ubiquitously and persistently present in the marine environment, but knowledge of its population-level effects is limited. In the present study, to quantify the potential theoretical population effect of microplastic, a two-step approach was followed. First, the impact of microplastic (polyethylene, 0.995 g cm−3, diameter 10–45 µm) on the filtration rate of the pelagic copepod Temora longicornis was investigated under laboratory conditions. It was found that the filtration rate decreased at increasing microplastic concentrations and followed a concentration–response relationship but that at microplastic concentrations &lt;100 particles L−1 the filtration rate was not affected. From the concentration–response relationship between the microplastic concentrations and the individual filtration rate a median effect concentration of the individual filtration rate (48 h) of 1956 ± 311 particles L−1 was found. In a second step, the dynamics of a T. longicornis population were simulated for realistic environmental conditions, and the effects of microplastics on the population density equilibrium were assessed. The empirical filtration rate data were incorporated in an individual-based model implementation of the dynamic energy budget theory to deduct potential theoretical population-level effects. The yearly averaged concentration at which the population equilibrium density would decrease by 50% was 593 ± 376 particles L−1. The theoretical effect concentrations at the population level were 4-fold lower than effect concentrations at the individual level. However, the theoretical effect concentrations at the population level remain 3–5 orders of magnitude higher than ambient microplastic concentrations. Because the present experiment was short-term laboratory-based and the results were only indirectly validated with field data, the in situ implications of microplastic pollution for the dynamics of zooplankton field populations remain to be further investigated. Environ Toxicol Chem 2022;41:1663–1674. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.