bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Necroptosis-Related lncRNA to Develop a Signature to Predict the Outcome, Immune Landscape, and Chemotherapeutic Responses in Bladder Urothelial Carcinoma
Authors: Hou Jian , Lu Zhenquan , Dong Runan , Wu Guoqing , Nie Haibo , Yang Guang , Tang Cheng , Qu Genyi , Xu Yong 
Published: June 2022

ObjectiveMany studies have drawn their attention to the immunotherapy of bladder urothelial carcinoma in terms of immunologic mechanisms of human body. These include immunogenicity of the tumor cells and involvement of long non-coding RNA (lncRNA). We constructed a necroptosis-related long noncoding RNA (nrlncRNA) risk factor model to predict BLCA outcomes and calculate correlations with chemosensitivity and immune infiltration.MethodsTranscriptomic data from BLCA specimens were accessed from The Cancer Genome Atlas, and nrlncRNAs were identified by performing co-expression analysis. Univariate analysis was performed to identify differentially expressed nrlncRNA pairs. We constructed least absolute contraction and selector operation regression models and drew receiver operating characteristic curves for 1-, 3-, and 5-year survival rates. Akaike information criterion (AIC) values for survival over 1 year were determined as cutoff values in high- and low-risk subgroups. We reassessed the differences between subgroups in terms of survival, clinicopathological characteristics, chemotherapy efficacy, tumor-infiltrating immune cells, and markers of immunosuppression.ResultsWe identified a total of 260 necroptosis-related lncRNA pairs, of which we incorporated 13 into the prognostic model. Areas under the curve of 1-, 3-, and 5- year survival time were 0.763, 0.836, and 0.842, respectively. We confirmed the excellent predictive performance of the risk model. Based on AIC values, we confirmed that the high-risk group was susceptible to unfavorable outcomes. The risk scores correlated with survival were age, clinical stage, grade, and tumor node metastases. The risk model was an independent predictor and demonstrated higher predictive power. The risk model can also be utilized to determine immune cell infiltration status, expression levels of immune checkpoint genes, and the sensitivity to cisplatin, doxorubicin, and methotrexate.ConclusionWe constructed a novel necroptosis-related signature that predicts BLCA outcomes and performs satisfactorily in the immune landscape and chemotherapeutic responses.
Older Age, Polypharmacy, and Low Systolic Blood Pressure Are Associated With More Hypotension-Related Adverse Events in Patients With Type 2 Diabetes Treated With Antihypertensives
Authors: Ambrož Martina , de Vries Sieta T. , Hoogenberg Klaas , Denig Petra 
Published: June 2022

Background and Aims: Low systolic blood pressure (SBP) levels while being treated with antihypertensives may cause hypotension-related adverse events (hrAEs), especially in the elderly, women, and frail patients. We aimed to assess the association between the occurrence of hrAEs and low SBP levels, age, sex, and polypharmacy among patients with type 2 diabetes (T2D) treated with antihypertensives.Methods: In this cohort study, we used the Groningen Initiative to ANalyse Type 2 diabetes Treatment (GIANTT) database which includes patients managed for T2D in primary care from the north of the Netherlands. Patients treated with ≥1 antihypertensive drug and ≥1 SBP measurement between 2012 and 2014 were included. The outcome was the presence of an hrAE, i.e. postural hypotension, dizziness, weakness/tiredness, and syncope in 90 days before or after the lowest recorded SBP level. Age (≥70 vs. &lt;70 years), sex (women vs. men), polypharmacy (5–9 drugs or ≥10 drugs vs. &lt;5 drugs), and SBP level (&lt;130 or ≥130 mmHg) were included as determinants. Logistic regression analyses were conducted for age, sex and polypharmacy, including the SBP level and their interaction, adjusted for confounders. Odds ratios (OR) with 95% confidence intervals (CI) are presented.Results: We included 21,119 patients, 49% of which were ≥70 years old, 52% were women, 57% had polypharmacy, 61% had an SBP level &lt;130 mmHg and 5.4% experienced an hrAE. Patients with an SBP level &lt;130 mmHg had a significantly higher occurrence of hrAEs than patients with a higher SBP level (6.2 vs. 4.0%; ORs 1.41, 95%CI 1.14–1.75, 1.43, 95%CI 1.17–1.76 and 1.33, 95%CI 1.06–1.67 by age, sex, and polypharmacy, respectively). Older patients (OR 1.29, 95%CI 1.02–1.64) and patients with polypharmacy (OR 5–9 drugs 1.27, 95%CI 1.00–1.62; OR ≥10 drugs 2.37, 95% CI 1.67–3.37) were more likely to experience an hrAE. The association with sex and the interactions between the determinants and SBP level were not significant.Conclusion: Low SBP levels in patients with T2D treated with antihypertensives is associated with an increase in hrAEs. Older patients and those with polypharmacy are particularly at risk of hrAEs. Age, sex, and polypharmacy did not modify the risk of hrAEs associated with a low SBP level.
Role of microRNA/lncRNA Intertwined With the Wnt/β-Catenin Axis in Regulating the Pathogenesis of Triple-Negative Breast Cancer
Authors: Hu Xue , Zhang Qiang , Xing Wanying , Wang Wan 
Published: June 2022

Objective (s): In this mini-review, we aimed to discuss the Wnt/β-catenin signaling pathway modulation in triple-negative breast cancer, particularly the contribution of lncRNAs and miRNAs in its regulation and their possible entwining role in breast cancer pathogenesis, proliferation, migration, or malignancy.Background: Malignant tumor formation is very high for breast cancer in women and is a leading cause of death all over the globe. Among breast cancer subtypes, triple-negative breast cancer is rife in premenopausal women, most invasive, and prone to metastasis. Complex pathways are involved in this cancer’s pathogenesis, advancement, and malignancy, including the Wnt/β-catenin signaling pathway. This pathway is conserved among vertebrates and is necessary for sustaining cell homeostasis. It is regulated by several elements such as transcription factors, enhancers, non-coding RNAs (lncRNAs and miRNAs), etc.Methods: We evaluated lncRNAs and miRNAs differentially expressed in triple-negative breast cancer (TNBC) from the cDNA microarray data set literature survey. Using in silico analyses combined with a review of the current literature, we anticipated identifying lncRNAs and miRNAs that might modulate the Wnt/β-catenin signaling pathway.Result: The miRNAs and lncRNAs specific to triple-negative breast cancer have been identified based on literature and database searches. Tumorigenesis, metastasis, and EMT were all given special attention. Apart from cross-talk being essential for TNBC tumorigenesis and treatment outcomes, our results indicated eight upregulated and seven downregulated miRNAs and 19 upregulated and three downregulated lncRNAs that can be used as predictive or diagnostic markers. This consolidated information could be useful in the clinic and provide a combined literature resource for TNBC researchers working on the Wnt/β-catenin miRNA/lncRNA axis.Conclusion: In conclusion, because the Wnt pathway and miRNAs/lncRNAs can modulate TNBC, their intertwinement results in a cascade of complex reactions that affect TNBC and related processes. Their function in TNBC pathogenesis has been highlighted in molecular processes underlying the disease progression.
Fiber-Enhanced Raman Spectroscopy for Trace-Gas Sensing in the High-Concentration Gas Background With an Anti-Resonant Hollow Core Fiber
Authors: Qian Guochao , Wan Fu , Zhou Feng , Wang Jianxin , Kong Weiping , Chen Weigen 
Published: June 2022

In this article, with an anti-resonant hollow core fiber (ARHCF), fiber-enhanced Raman spectroscopy (FERS) for trace-gas sensing in a high-concentration gas background is demonstrated for the first time. The performance of the apparatus is verified by detecting trace-gas in the high concentration SF6 and gaseous impurities in the high concentration C2H6. With a 1.5 W laser source and 60 s exposure time, the limit of detection (LOD) of gases at tens of ppm levels is achieved, including carbonyl sulfide (COS), carbon tetrafluoride (CF4), carbon dioxide (CO2), carbon monoxide (CO), methane (CH4), acetylene (C2H2), ethylene (C2H4), propyne (C3H4), propylene (C3H6), and propane (C3H8). Quantification of multi-gas with great accuracy exceeding 94% is also realized. It shows that the FERS can demonstrate the ability of multi-gas sensing with high selectivity, sensitivity, and accuracy.
Distinguishing the Associations Between Evening Screen Time and Sleep Quality Among Different Age Groups: A Population-Based Cross-Sectional Study
Authors: Sun Long , Li Keqing , Zhang Lili , Zhang Yunshu 
Published: June 2022

ObjectiveThe age differences in the association between screen time and sleep problems have been implied in many studies, and this study aims to distinguish the associations between evening screen time and sleep quality among different age groups.MethodsThis is a population-based, cross-sectional study among community residents aged ≥18 years in China. A total of 21,376 valid questionnaires were analyzed. Sleep quality was measured by the Pittsburgh Sleep Quality Index. Averaged evening screen time (AEST), sociodemographic information, and health-related behaviors were also evaluated in this study.ResultsIn the 18-to-34-year age group, compared with people without AEST, ≤1 h/day (β = 0.34, p &lt; 0.05) and &gt;3 h/day (β = 1.05, p &lt; 0.001) of AEST were significantly associated with poor sleep quality, and a reverse S-shaped relationship for this association was shown. In the 35-to-49-year and 50-to-64-year age groups, ≤1 h/day (β = 0.43 and 0.36, both p &lt; 0.001), ≤2 h/day (β = 0.43 and 0.31, p &lt; 0.001 and p &lt; 0.01), ≤3 h/day (β = 0.62 and 0.61, both p &lt; 0.001), and &gt;3 h/day (β = 1.55 and 1.88, both p &lt; 0.001) of AEST were positively associated with poor sleep quality. In the 65-year-and-older age group, a J-shaped relationship was found, and ≤3 h/day (β = 0.82, p &lt; 0.001) and &gt;3 h/day (β = 1.84, p &lt; 0.001) of AEST were associated with poor sleep quality.ConclusionAssociations between AEST and sleep quality among different age groups are different. In the 18-to-34-year and 65-year-and-older age groups, acceptable AEST is not related to sleep quality. In the 35-to-49-year and 50-to-64-year age groups, AEST was harmful to sleep quality.
Utilization and Acceptability of Formal and Informal Support for Adolescents Following Self-Harm Before and During the First COVID-19 Lockdown: Results From a Large-Scale English Schools Survey
Authors: Geulayov Galit , Borschmann Rohan , Mansfield Karen L. , Hawton Keith , Moran Paul , Fazel Mina 
Published: June 2022

BackgroundLittle is known about the perceived acceptability and usefulness of supports that adolescents have accessed following self-harm, especially since the onset of the COVID-19 pandemic.AimsTo examine the utilization and acceptability of formal, informal, and online support accessed by adolescents following self-harm before and during the pandemic.MethodCross-sectional survey (OxWell) of 10,560 secondary school students aged 12–18 years in the south of England. Information on self-harm, support(s) accessed after self-harm, and satisfaction with support received were obtained via a structured, self-report questionnaire. No tests for significance were conducted.Results1,457 (12.5%) students reported having ever self-harmed and 789 (6.7%) reported self-harming during the first national lockdown. Informal sources of support were accessed by the greatest proportion of respondents (friends: 35.9%; parents: 25.0%). Formal sources of support were accessed by considerably fewer respondents (Child and Adolescent Mental Health Services: 12.1%; psychologist/ psychiatrist: 10.2%; general practitioner: 7.4%). Online support was accessed by 8.6% of respondents, and 38.3% reported accessing no support at all. Informal sources of support were rated as most helpful, followed by formal sources, and online support. Of the respondents who sought no support, 11.3% reported this as being helpful.ConclusionsMore than a third of secondary school students in this sample did not seek any help following self-harm. The majority of those not seeking help did not find this to be a helpful way of coping. Further work needs to determine effective ways of overcoming barriers to help-seeking among adolescents who self-harm and improving perceived helpfulness of the supports accessed.
Examining Risk Factors for Mental Health During the COVID-19 Pandemic—Focusing on Older Adults in South Korea
Authors: Kim Sujin , Hwang Jongnam 
Published: June 2022

Objectives: Mental health is the cornerstone of public health, particularly for older adults. There is a clear need to examine the impact of COVID-19 on mental health among older adults in South Korea, where the incidence of COVID-19 was relatively low and widespread transmission was controlled without a national lockdown.Methods: This analysis included a total of 1917 participants from the Experience Survey on Healthcare Use of Older Adults, which was conducted for adults aged 65 years or older by face-to-face interview.Results: The results showed that older adults with a good understanding of COVID-19 public health measures were less likely to experience mental health problems. In contrast, those with a greater risk perception of contracting COVID-19 had higher odds of experiencing tension and anxiety in addition to sadness and depression. Older adults who had a greater fear of COVID-19 and perceived higher-risk of contracting COVID-19 experienced more sleep problems.Conclusion: The findings provide new evidence on the factors that influence the mental health of older adults in South Korea during the pandemic and suggest the development of policy interventions.
Effect of SiO2 sublayer on the retention characteristics of nanometer-sized Si3N4 memristive devices investigated by low-frequency noise spectroscopy
Authors: Kochergin Viktor S. , Yakimov Arkady V. , Klyuev Alexey V. , Filatov Dmitry O. , Gorshkov Oleg N. , Antonov Dmitry A. , Mikhaylov Alexey N. , Sunyaikin Denis V. , Shtraub Nikolay I. , Vasileiadis Nikolaos , Dimitrakis Panagiotis , Spagnolo Bernardo 
Published: June 2022

Abstract
The results of the experimental investigation of the relationship between the low-frequency noise spectrum of the electric current through conducting filaments in Si3N4 films with a thickness of 6 nm on n
++-Si(001) conducting substrates and retention characteristics of these filaments are reported. Two structures are investigated: Si3N4/Si, thin (about 6 nm) Si3N4 film on the n++-Si substrate; Si3N4/SiO2/Si, a similar structure with a 2 nm SiO2 sublayer between the film and the substrate. A detailed comparison of the experimentally extracted parameters, such as average current through the filament, probability density function, and spectrum, is presented with a discussion of possible physical reasons for the difference between the testing structures and their effect on retention characteristics.
Problems of Searching for an Artistic Image and Stylistic Orientation Architecture of Voronezh at the Turn of the Twentieth and Twenty-First Centuries
Authors: Гилев С. А. 
Published: June 2022

Постановка задачи. Анализируются стилистические направления некоторых объектов, построенных в Воронеже на рубеже двадцатого и двадцать первого веков. Результаты. Выполнен сравнительный анализ архитектурно-художественных особенностей и стилистической направленности проектных решений объектов, дана оценка их влиянию на окружающую городскую среду и формирование архитектурного облика Воронежа. Выводы. Строительство ряда объектов на рубеже этого периода и целенаправленные поиски художественного образа в архитектуре зданий существенно обогатили архитектурный облик городской среды, сделали ее более разнообразной и интересной.
Statement of the problem. The article analyzes the stylistic trends of some objects built in Voronezh at the turn of the twentieth and twenty-first centuries. Results. A comparative analysis of architectural and artistic features and stylistic orientation of design solutions of objects, their impact on the urban environment and the formation of the architectural appearance of Voronezh is carried out. Conclusions. Construction of some objects at the turn of this period and purposeful search for an artistic image in building architecture enormously enriched the cityscape and made it more appealing and diverse.
Designing an Artistic Interior: Some Issues and Development Prospects of the Industry Under Sanctions
Authors: Подольская Л. В. 
Published: June 2022

Постановка задачи. Рассматривается проблема поиска новых путей развития отечественной архитектуры и дизайна интерьеров в современных условиях. Результаты. Отмечается, что уход с российского рынка западноевропейских мебельных магазинов и глянцевых журналов обнажил серьезную проблему - утрату собственного стиля, индивидуальности, творческого подхода. Отечественные дизайнеры и архитекторы в последние десятилетия привыкли работать, ориентируясь на зарубежные образцы, заимствуя идеи и решения. А в отсутствие зарубежных материалов, мебели, предметов интерьера такой подход вызвал растерянность многих специалистов. Выводы. Сложившаяся ситуация некоторой «оторванности» от западного рынка открывает новые перспективы для российских дизайнеров и архитекторов, связанные с поиском собственного стиля, художественного образа, ориентированных на отечественную культуру, историю. Необходим осознанный подход к художественному проектированию, формированию собственного стиля с ориентацией на отечественного производителя и отечественные материалы. В этом контексте особенно интересным представляется изучение архитектуры и интерьеров советского периода, которые в силу политических обстоятельств были закольцованы на внутреннее производство, причем не только строительных материалов, но художественных, монументальных работ.
Statement of the problem. The problem of searching for new ways of developing the domestic architecture in interior design in modern conditions is explored. Results. It is noted that moving away from the Russian market of Western European furniture stores and glossy magazines has brought to the surface a serious issue of losing a unique style, individuality and an artistic approach. Designers and architects in this country in the last decades have got used to working guided by foreign approaches, borrowing ideas and solutions. With no foreign materials, furniture items being available, this approach has puzzled a lot of specialists in the industry. Conclusions. The current «isolation» from the foreign market opens up new opportunities for Russian designers and architects related to searching for their own style employing domestic production and materials. Therefore it is of particular interest to investigate the architecture and interiors of the Soviet era which due to the political circumstance at the time were centred around the domestic production of not only construction materials but also artistic monumental pieces.
Pengaruh Motivasi Kerja, Kepuasan Kerja dan Komitmen Organisasional terhadap Organizational Citizenship Behavior pada Karyawan PT PLN (Persero) UP3 Ternate
Authors: R Ismail Nurul Husna , Nurlaila Nurlaila , M. Mustafa Ikrima 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh Motivasi Kerja, Kepuasan Kerja dan Komitmen Organisasional secara parsial maupun secara simultan terhadap Organizational Citizenship Behavior (OCB) karyawan PT. PLN (Persero) UP3 Ternate. Penelitian ini menggunakan pendekatan kuantitatif. Populasi yang digunakan dalam penelitian ini meliputi seluruh karyawan PT. PLN (Persero) UP3 Ternate sebanyak 50 orang. Teknik pengumpulan data dilakukan melalui observasi, wawancara serta pembagian kuesioner dimana pada pembagian kuesioner menggunakan teknik probability sampling dengan jenis simple random sampling. Adapun analisis data penelitian ini menggunakan bantuan SPSS versi 26 sebagai alat uji statistic. Hasil penelitian menunjukan bahwa (1) Hasil Uji Parsial memperlihatkan nilai signifikansi Motivasi Kerja terhadap Organizational Citizenship Behavior (OCB) menunjukan bahwa tidak terdapat pengaruh Motivasi Kerja terhadap Organizational Citizenship Behavior (OCB) karyawan di PT PLN (Persero) UP3 Ternate. Pada Standardized Coefficients beta (?) memperlihatkan pengaruh negatif. (2) Nilai signifikansi pengaruh Kepuasan Kerja terhadap Organizational Citizenship Behavior (OCB) memperlihatkan terdapat pengaruh Kepuasan Kerja terhadap Organizational Citizenship Behavior (OCB) karyawan di PT PLN (Persero) UP3 Ternate. Sedangkan pada Standardized Coefficients beta (?) memperlihatkan pengaruh positif. (3) Nilai signifikansi pengaruh Komitmen Organisasional terhadap Organizational Citizenship Behavior (OCB) menunjukan bahwa terdapat pengaruh Komitmen Organisasional terhadap Organizational Citizenship Behavior (OCB) karyawan di PT PLN (Persero) UP3 Ternate. Sedangkan pada Standardized Coefficients beta (?) memperlihatkan pengaruh positif. (4) Berdasarkan hasil Uji Regresi Linear Berganda diketahui nilai signifikansi pengaruh variabel Motivasi Kerja, Kepuasan Kerja, dan Komitmen Organisasional secara simultan berpengaruh terhadap Organizational Citizenship Behavior (OCB) karyawan di PT PLN (Persero) UP3 Ternate dengan persentase pengaruh secara simultan sebesar 76,7%.
CPC – Eine neue Betonbauweise – Bemessungskonzept/CPC – A new concrete construction method – Design concept
Authors: Rusch Mona , Brunner Micha , Kurath Josef 
Published: June 2022

Vor Kurzem haben die in der Schweiz bereits häufig eingesetzten CPC-Platten (carbon prestressed concrete) die allgemeine bauaufsichtliche Zulassung durch das DIBt (Deutsche Institut für Bautechnik) mit der Zulassungsnummer Z-71.3–42 erhalten. Nun wird es einfacher, die extrem leistungsfähigen CPC-Platten auch in Deutschland einzusetzen. Durch die hohe Festigkeit der Carbonbewehrung, deren vorgespannten Einbau in der Platte und der Korrosionsbeständigkeit können Bauteile in CPC-Bauweise bei gleicher Biegetragfähigkeit deutlich schlanker und somit leichter ausgestaltet werden als herkömmliche Stahlbetonplatten. Dies eröffnet neue architektonische Möglichkeiten und führt durch eine wesentliche Reduktion des CO2-Ausstoßes und einer wesentlichen Verbesserung der Massenbilanz zu einer großen Verbesserung der Ökobilanz bei Bauwerken [1] und [2].

Im vorliegenden Artikel werden die Eigenschaften von CPC-Platten aufgezeigt sowie das Bemessungskonzept vorgestellt. Es wird auf zwei klassische Beispiele, eine Balkonplatte sowie ein Bohlenbelag für eine Fuß- und Fahrradbrücke, näher eingegangen.