bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircRNA_0000927 promotes inflammatory response to neuronal injury via miR-126a-5p/PGC-1α axis in acute ischemic stroke
Authors: Wang Meng , Li Hong , Qian Yulin , Zhao Shanshan , Wang Hao , Wang Yu , Yu Tao 
Published: December 2022

Abstract
Purpose
We investigated the role of CircRNA_0000927 on the occurrence and development of acute ischemic stroke (AIS) and neuronal injury by targeting the miR-126a-5p/PGC-1α axis to find a novel clinical drug target and prediction and treatment of AIS.
Methods
The mouse AIS animal model was used in vivo experiments and hypoxia/reoxygenation cell model in vitro was established. Firstly, infarction volume and pathological changes of mouse hippocampal neurons were detected using HE staining. Secondly, rat primary neuron apoptosis was detected by flow cytometry assay. The numbers of neuron, microglia and astrocytes were detected using immunofluorescence (IF). Furthermore, binding detection was performed by bioinformatics database and double luciferase reporter assay. CircRNA_0000927 localization was performed using fluorescence in situ hybridization (FISH). CircRNA_0000927, miR-126a-5p and PGC-1α mRNA expression was performed using RT-qPCR. NLRP3, ASC, Caspase-1 and PGC-1α protein expression was performed using Western blotting. IL-1β was detected by ELISA assay.
Results
Mouse four-vessel occlusion could easily establish the animal model, and AIS animal model had an obvious time-dependence. HE staining showed that, compared with the sham group, infarction volume and pathological changes of mouse hippocampal neurons were deteriorated in the model group. Furthermore, compared with the sham group, neurons were significantly reduced, while microglia and astrocytes were significantly activated. Moreover, the bioinformatics prediction and detection of double luciferase reporter confirmed the binding site of circRNA_0000927 to miR-126a-5p and miR-126a-5p to PGC-1α. CircRNA_0000927 and PGC-1α expression was significantly down-regulated and miR-126a-5p expression was significantly up-regulated in AIS animal model in vivo. At the same time, the expression of inflammasome NLRP3, ASC, Caspase-1 and pro-inflammatory factor IL-1β was significantly up-regulated in vivo and in vitro. The over-expression of circRNA_0000927 and miR-126a-5p inhibitor could inhibit the neuron apoptosis and the expression of inflammasome NLRP3, ASC, Caspase-1 and pro-inflammatory factor IL-1β and up-regulate the expression of PGC-1α in vitro. Finally, over-expression of circRNA_0000927 and miR-126a-5p inhibitor transfected cell model was significant in relieving the AIS and neuronal injury.
Conclusion
CircRNA_0000927 promotes inflammatory response to neuronal injury via miR-126a-5p/PGC-1α axis in AIS.
Energy gaps and plateau characteristics in the fractional quantum Hall effect derive from multi-particle correlations
Authors: Hong Jongbae 
Published: December 2022

Abstract
The energy gaps appearing in the fractional quantum Hall effect (FQHE) remain an important aspect of investigation. Moreover, the plateau widths in the Hall resistance have been considered simply an effect of disorder as in the integral quantum Hall effect. The existing theories could neither explain the Hall resistance curve owing to plateau widths nor calculate the energy gaps. This study reveals that both the energy gaps and plateau widths contain fundamental many-body aspects of the FQHE, and they are found to be connected via the strengths of multi-particle correlations, which do not affect the vertical positions of plateau that are automatically quantized just by the presence of inter-electron interaction. This work focuses on correlated electrons moving through the edge of an incompressible strip formed within a Hall bar. Consequently, a single-particle Hamiltonian was constructed incorporating the Zeeman energies of multiply-correlated skipping electrons. The resulting energy spectrum exhibits hierarchical Landau level splits according to correlation order. The lowest Landau level is examined. Based on such level splitting, a previously measured Hall resistance curve and energy gaps are quantitatively explained by determining the parameters that describe the degrees of multi-particle correlations. The chemical potential and effective g-factors are additionally predicted.
Measurement of the Reynolds Number Dependence of a Transient Air Jet from a Pressure Vessel
Authors: Fischer Michael-David , Ryll Fabienne , Boettcher Konrad E.R. 
Published: December 2022

Abstract
Although a free jet is a well investigated problem in literature, there are still some aspects that are discussed controversially. Especially the Reynolds number Re dependence of the propagation behaviour is an open question. This problem was addressed on the basis of experimental investigations of compressible, transient, subcritical, round air jets. For this purpose, the velocity field of sudden horizontal vessel discharges were considered experimentally for the first time with a phase Doppler anemometer in the range of up to 60 times the outlet diameter. The determination of the particle size in addition to the velocity provided an important basis for validation. This ensured that only particles with an almost perfect following behaviour exhibiting the gas velocity were considered. Statistical analyses show a significant influence of the Reynolds number Re on the decay rate K1,u with a significance value p = 1.703 ⋅ 10-4 and spreading rate K2,u with p = 1.453 ⋅ 10-6 in the investigated range of Reynolds number 30 000 ≤ Re ≤ 400 000. With increasing Reynolds number Re, the decay rate increases K1,u and the spreading rate K2,u decreases. This disproves the theory that the propagation of free jets is independent of the Reynolds number Re. Since the influence of the Reynolds number is relatively small, the specification of an average value and a quasi-self-similar behaviour seems to be appropriate. The average decay constant is K1,u = 5.86 and the average spreading rate is K2,u = 0.096.
Direct OC-CHO coupling towards highly C2+ products selective electroreduction over stable Cu0/Cu2+ interface
Authors: Zhang Xin Yu , Lou Zhenxin , Chen Jiacheng , Liu Yuanwei , Wu Xue Feng , Zhao Jia Yue , Yuan Haiyang , Zhu Minghui , Dai Sheng , Wang Haifeng , Sun Chenghua , Liu Peng Fei , Yang Huagui 
Published: December 2022

AbstractElectroreduction of CO2 to valuable multicarbon (C2+) products is a highly attractive way to utilize and divert emitted CO2. However, a major fraction of C2+ selectivity is confined to less than 90% by the difficulty of coupling C-C bonds efficiently. Herein, we identify the stable Cu0/Cu2+ interfaces derived from copper phosphates-based (CuPO) electrocatalysts, which can facilitate C2+ production with a low-energy pathway of OC-CHO coupling verified by in situ spectra studies and theoretical calculations. The CuPO precatalyst shows a high Faradaic efficiency (FE) of 69.7% towards C2H4 in an H-cell, and exhibits a significant FEC2+ of 90.9% under industrially relevant current density (j = -350 mA cm-2) in a flow cell configuration. The stable Cu0/Cu2+ interface breaks new ground for the structural design of electrocatalysts and the construction of synergistic active sites to improve the activity and selectivity of valuable C2+ products.
A case of traumatic cataract caused by cosmetic laser and literature review
Authors: Li Bingzhen , Zhang Jiaxin , Wang Haikun , Dai Jinyue , Li Xuemin 
Published: December 2022

Abstract
Background
Eye injury is one of the most disastrous complications of laser cosmetic treatment, among them, traumatic cataract is very rare.
Methods
This paper reports a rare case of traumatic cataract with iris injury, hyphema and secondary glaucoma caused by cosmetic laser, and reviews the previous cases of cataract after cosmetic laser.
Results
The trajectory of laser was unexpectedly found in the lens of both eyes, up to 7 months of follow-up showed that the cataract had no significant effect on vision, only photophobia was retained.
Conclusion
The incidence of cosmetic laser-induced cataract may be much higher than currently realized and appropriate eye protection is very important during cosmetic laser treatment.
Emergent Cooperation from Mutual Acknowledgment Exchange in Multi-Agent Reinforcement Learning
Authors: Phan Thomy , Sommer Felix , Ritz Fabian , Altmann Philipp , Nüßlein Jonas , Kölle Michael , Belzner Lenz , Linnhoff-Popien Claudia 
Published: December 2022

Abstract
Peer incentivization (PI) is a recent approach, where all agents learn to reward or to penalize each other in a distributed fashion which often leads to emergent cooperation. Current PI mechanisms implicitly assume a flawless communication channel in order to exchange rewards. These rewards are directly integrated into the learning process without any chance to respond with feedback. Furthermore, most PI approaches rely on global information which limits scalability and applicability to real-world scenarios, where only local information is accessible. In this paper, we propose Mutual Acknowledgment Token Exchange (MATE), a PI approach defined by a two-phase communication protocol to mutually exchange acknowledgment tokens to shape individual rewards. Each agent evaluates the monotonic improvement of its individual situation in order to accept or reject acknowledgment requests from other agents. MATE is completely decentralized and only requires local communication and information. We evaluate MATE in three social dilemma domains. Our results show that MATE is able to achieve and maintain significantly higher levels of cooperation than previous PI approaches. In addition, we evaluate the robustness of MATE in more realistic scenarios, where agents can defect from the protocol and where communication failures can occur. We also evaluate the sensitivity of MATE w.r.t. the choice of token values.
Multi-stable spatial patterns and spatiotemporal staggered periodic patterns in a predator-taxis model with delay
Authors: Xing Yue , Jiang Weihua , Cao Xun 
Published: December 2022

Abstract
The effects of predator-taxis and conversion time delay on formations of spatiotemporal patterns in a predator-prey model are explored. Firstly, the well-posedness, which implies global existence of classical solutions, is proved.Then, we establish critical conditions for the destabilization of coexistence equilibrium through Turing/Turing-Turing bifurcations via describing the first Turing bifurcation curve, and theoretically predict possible bi-stable/multi-stable spatially heterogeneous patterns. Next, we demonstrate that coexistence equilibrium can also be destabilized through Hopf, Hopf-Hopf, Turing-Hopf bifurcations, and possible stable/bi-stable spatially inhomogeneous staggered periodic patterns, bi-stable spatially inhomogeneous synchronous periodic patterns, are theoretically predicted.Finally, numerical experiments also support theoretical predictions and partially extend them. In a word, theoretical analyses indicate that, on the one hand, large predator-taxis can eliminate spatial patterns caused by self-diffusion; on the other hand, the joint effects of predator-taxis and conversion time delay can induce complex survival patterns, e.g., bi-stable spatially heterogeneous staggered/synchronous periodic patterns, thus diversify populations' survival patterns.
Mathematics Subject Classification (2020) 35B32 · 35K57 · 92C15
The Surgical Strategy of Juvenile Nasopharyngeal Angiofibroma: A Case Report
Authors: Liu Shengyang , Yu Liang , Yu Peng , Sun Shujuan , Wang Yuedong , Liu Shanfeng , Shi Li , Wan Yuzhu , Chen Aiping 
Published: December 2022

Abstract
Surgical resection to remove juvenile nasopharyngeal angiofibroma is challenging due to the high risk of massive hemorrhage. We report a comprehensive strategy which included preoperative devascularization by embolizing the feeding arteries and combined endoscopic and transoral approach was adopted.
Mathematical scrutiny of singular predator-prey model with stage-structure of prey
Authors: YADAV UGANTA , Nayak Ameeya Kumar , Gakkhar Sunita 
Published: December 2022

Abstract
In this paper, a stage structured predator-prey model with Holling type II functional response is formulated, considering the juvenile prey as the favorite food for the generalist predator. Further, the existence of predators is ensured by the sufficient amount of alternative food available in the habitat. The proportional harvesting of the adult prey is incorporated with the assumption that only the adult prey are of economic worth. The existence and local stability of the distinct equilibrium points of the system are investigated. The bifurcation from origin to predator free equilibrium state is obtained for the bifurcation parameter-effort on harvesting. The occurrence of Hopf bifurcation about the interior equilibrium state is established for arbitrary model parameters and the supercritical nature of this bifurcation is proved by fixing these parametric values. An algebraic equation is included to this modified model to analyze the economic benefits resulted from the harvesting of adult prey. The singularity-induced bifurcation (SIB) about the coexisting equilibrium state of differential-algebraic system is deduced along the parameter v at v = 0, v being the profit/loss due to harvesting. The state feedback controller is recommended to eliminate the SIB about the coexisting equilibrium state for the differential algebraic system. Adopting an appropriate feedback control would ensure the stability of coexistence interior equilibrium state along with economic profit from harvesting. Numerical examples are used to elaborate the analytical results obtained.
Development and Validation of an Immune-related Gene Diagnostic Model for Cancerous Change in Oral Leukoplakia
Authors: Lin Yang , Gao Bingju , Li Jun , Chen Peng , Qiu Yu 
Published: December 2022

AbstractBackground: Oral squamous cell carcinoma (OSCC) is usually preceded by oral potentially malignant disorders, Such as oral leukoplakia (OLK). The prevention of the transformation of OLK to OSCC may significantly improve clinical outcomes of patients. Recent studies have highlighted the dynamics of immune microenvironment during oral carcinogenesis. Given this context, this study aimed to development an immune-related gene diagnostic model for predicting malignant transformation of OLK to OSCC.Methods: In this study, we first compared immune cell infiltration between the control and OLK and OSCC from two GEO databases (GSE85195 and GSE23558) using CIBERSORT algorithm. Next, we compared differentially expressed genes between the control and OSCC and OLK and OSCC using the LIMMA package. Finally, developed an immune-related gene diagnostic model using the LASSO regression and used the GSE26549 and TCGA databases to validate the model’s predictive ability.Results: The composition of 22 types of immune cells in each sample was presented in a boxplot (figure 1A). The expression of dendritic cells resting, macrophages M0, macrophages M2, and mast cells resting were significantly different between the OLK and OSCC groups (P<0.001).1432and 1256 DEGs were identified from GSE85195 and GSE23558, respectively. Overlapping differential DEGs and the 2483 immune-related genes. Sixty-nine candidate genes were integrated into the LASSO regression to identify OLK cancerous immune signatures. The area under ROC curve (AUC) in the training and internal validation cohorts were 1 and 0.994(figure 4A), respectively. Finally, a model comprising 16 immune signatures was constructed.Conclusions: This study develop and validate an immune-related gene diagnostic model was a promising objective diagnosis scheme to predict cancer risk of OLK to OSCC.
Higher indocyanine green retention rates predicted improved prognoses in hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization
Authors: Fujita Koji , Morishita Asahiro , Nakahara Mai , Ono Masafumi , Himoto Takashi , Masaki Tsutomu 
Published: December 2022

Abstract
Progression of liver fibrosis causes portal hypertension with thrombocytopenia, and intrahepatic hypoperfusion with mesenchymal dysfunction evaluated by the indocyanine green retention rate at 15 minutes (ICG-R15), in which the serum levels of indocyanine green are measured 15 minutes after bullous injection. Thrombocytopenia caused by portal hypertension has been associated with improved prognosis in hepatocellular carcinoma (HCC) patients treated using transcatheter arterial chemoembolization therapy (TACE). However, the clinical significance of higher ICG-R15 in HCC patients treated with nonsurgical therapies is poorly established. This study aimed to clarify the correlation between ICG-R15 and prognosis of HCC in patients treated with TACE. Briefly, we included HCC patients treated with TACE after ICG-R15. Cox proportional hazard model analysis was performed to identify independent prognostic factors. After adjusting for age, sex, stage of hepatocellular carcinoma, albumin bilirubin score, etiologies, and baseline year by propensity score matching, the prognostic impact of higher ICG-R15 was evaluated using the Kaplan–Meier curve. As results, 278 patients were included in this study. Univariate and multivariate analyses identified higher ICG-R15 and lower platelet count as positive prognostic factors for overall survival. Propensity score matching generated two 77-patient cohorts, ICG-R15<20% group and ICG-R15>20% one. The overall survival of the ICG-R15>20% group was significantly better than that of ICG-R15<20%. In conclusions, higher ICG-R15 in addition to lower platelet count acted as positive long-term prognostic factors in HCC patients treated with TACE.
Measurement of radium content and radon exhalation rates in Egyptian construction material samples using sealed-cup technique and LR-115 detectors
Authors: Hussein A. S. 
Published: December 2022

Abstract
Effective radium content and radon exhalation rate in twenty construction material samples collected from the local market in Egypt were measured using the sealed–cup technique based on LR-115 nuclear track detectors. The values of effective radium content were found to vary from 1.93 to 360.21 Bqkg− 1. Mass exhalation rate values were found to vary from 5.75x10− 9 to 1073.43x10− 9 Bqkg− 1h− 1. Area (surface) exhalation rate values were found to vary from 0.30x10− 6 to 55.80x10− 6 Bqm− 2h− 1. All the results obtained in the present work were found to be less than their corresponding world limits. Thus, the present results have revealed that, effective radium content and both area and mass exhalation rates in the studied samples do not pose risk to human health. The results were compared with national and some other countries.
Performance analysis of recycled carbon fiber under recycling process parameters optimized using response surface methodology
Authors: Cheng Huanbo , Wang Huafeng , Zhou Jinhu , Guo Lijun , Wang Qingze , Tang Mingxi 
Published: December 2022

Abstract
The recycling of high-performance carbon fiber from carbon fiber-reinforced polymer (CFRP) wastes have great economic value and environmental significance. Based on the principle of thermally activated oxide semiconductors, quantitative relationship model between the decomposition rate of the resin-matrix and the process parameters was established. The morphology, elements, functional groups and mechanical properties of recycled carbon fiber(rCF) were analyzed under the optimal process parameters. The results indicated that the decomposition rate of resin was positively correlated with time and temperature, and the degree of influence was significant, the effect of O2 flow rate and concentration were not significant. The influence of each factor indicates showed that temperature > time > O2 concentration > O2 flow rate. The actual decomposition rate of resin was 96.12% under temperature of 520 ℃, time of 23 min, O2 concentration of 80% and flow rate of 180 mL/min. Compared with the original carbon fiber(oCF), the surface roughness of recycled carbon fiber was increased, and there was no carbon deposition residue on the surface. The content of C element and C—C bond on the surface of rCF increased significantly, and functional group of COOH was produced, the graphite structure on the surface of carbon atomic surface change was not significant. The tensile strength of rCF was maintained above 99%, the Young's modulus was maintained at 92%, and the interfacial shear strength was maintained at 85%.
Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress
Authors: Wu Xiao , Fan Yaoran , Ma Keyi , Li Jiale , Feng Jianbin 
Published: December 2022

Abstract
Temperature is an essential factor affecting the viability of crustaceans, and high temperature can cause damage or even death. The oriental river prawn, Macrobrachium nipponense, is an important economic aquaculture species in China, Japan, and Vietnam. To identify the transcriptomic, histological, and biochemical response of M. nipponense and reveal their adaptation mechanisms, the prawns were placed at 25 ℃, 30 ℃, and 35 ℃ for 24 h. The histological damages in the gills and hepatopancreas of M. nipponense were found under acute heat stress. Additionally, acute heat stress enhanced the digestive, metabolic, and antioxidative capacity of M. nipponense by biochemical analysis. The total RNA of hepatopancreas and gills were isolated and sequenced using the RNA-Seq method. After filtration, assembly, and aggregation, a total of 131690 unigenes were identified. Gene ontology (GO) analysis revealed that differentially expressed genes (DEGs) were significantly involved in the regulation of transcription by RNA polymerase II, proteolysis, nucleus, cytoplasm, nucleus, and ATP binding. In the hepatopancreas, several pathways were significantly enriched in the treatment groups, including neuroactive ligand-receptor interaction, thyroid hormone synthesis, and ECM-receptor interaction. And in the gills, cGMP-PKG signaling pathway, ribosome, and calcium signaling pathway, were enriched. The transcriptomic analysis provided insights into the thermoregulation and molecular mechanisms of M. nipponense in response to acute heat stress.
Test Development for Power Management Integrated Circuit
Authors: Veenadevi S V , Aihole Soumya N 
Published: December 2022

Abstract
Integrated circuits are the basic building blocks of almost all commercial electronic devices, such as workstations, mobile phones, personal computers, automation hardware, automobiles, modern gear, military hardware, and home appliances. A single IC defect can cause the entire system to fail. Every IC must meet the technical specifications defined in the database during the IC manufacturing process. Unfortunately, a small number of ICs fail to meet the required standards sometimes. These faults must be identified prior to the product has been released to the market. As a result, testing necessitates the development of a test environment, an integration of hardware and software that ensures the quality of the product comparable to that of any other. The purpose of the project is to create a test solution for the Smart High Side Switch which is a Power Management IC. Test program for the device is developed such that it verifies all the specifications as mentioned in the database. Characterization of the device is also performed to statistically analyze the quality and life span of the device. The testing is done on Eagle Test Systems(ETS) ATE and verified all specifications.