bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Fano resonance and its application in MIM waveguide using a k-shaped Resonator
Authors: Fan Haopeng , tian jinping , Yang Rongcao 
Published: July 2022

Abstract
In this paper, a plasmonic MIM waveguide consisting of a k-shaped resonant cavity is designed, which can support three Fano resonances. The physical mechanisms behind the multiple Fano resonances are studied with the help of field distributions and the changes of geometric parameters. Further, by varying the refractive index of the dielectric medium filled in the air part of the waveguide, property of refractive index sensing is studied. The maximum sensitivity is up to 1250 nm/RIU and the maximum figure of merit is more than 4000. Eventually the slow-light effect is also investigated, and the results show that the maximum optical delay and the group index are about 0.05ps and 9.23, respectively. All the results may provide some fundamental references for the design of plasmonic optical waveguide devices, and it will also have potential applications in areas such as nanoscale refractive index sensing, slow-light effects, photonic device integration, and so on.
Nationwide study of risk factors for reoperation after surgical treatment for degenerative spinal disease in Poland
Authors: Słowiński Jerzy , Żurek Michał , Wypych-Ślusarska Agata , Krupa-Kotara Karolina , Oleksiuk Klaudia , Głogowska-Ligus Joanna , Kozioł Anna , Kozioł Milena 
Published: July 2022

Abstract
Background
The aim of the study is to evaluate the reoperation rate after surgical treatment for degenerative spinal diseases (DSD) in Poland and to identify risk factors for reoperation, including comorbidities and other variables.
Methods
A retrospective analysis of hospitalisations in 2018 that were reported to the National Health Fund (NHF) using ICD-10 codes: M43.1, M47, M48, M50, M51, M53 and Diagnosis Related Group (DRG) codes: A22, A23, A27, H51, H52, H53, H55. Reoperations were identified using the same codes provided that they were reported within 365 days after discharge. The analysis involved demographic factors and patient multimorbidity. A logistic regression model was then performed to assess risk factors for reoperation.
Results
In 2018, 38,953 surgical hospitalisations for DSD were reported. A total of 3,942 hospitalised patients (10.12%) needed reoperation within 365 days. Patients requiring reoperation were predominantly women (1.34:1) and the elderly (mean age: 56.66 vs. 53.24). The percentage of reoperations correlated with the multimorbidity rate (from 8.81–15.31%). The risk of reoperation was most increased by concomitant depression, neurological diseases, obesity and older age. The risk of reoperation was reduced by instrumented spinal surgery, operations in a neurosurgical department and hospitalisations other than day-surgery.
Conclusions
Reoperations within the first year of surgical treatment for DSD are common. Identification of risk factors for reoperation, including those related to the presence of comorbidities and the phenomenon of multimorbidity, can be an important tool in reducing the reoperation rate.
Insights into the mechanism of pre-mRNA splicing of tiny introns from the genome of a giant ciliate Stentor coeruleus
Authors: Chanarat Sittinan , Nuadthaisong Jirayu , Techawisutthinan Chanakan 
Published: July 2022

Abstract
Stentor coeruleus is a ciliate known for its regenerative ability. Recent genome sequencing reveals that its spliceosomal introns are exceptionally small. We wondered whether the multi-megadalton spliceosome has any unique characteristics for removal of the tiny introns. First, we analyzed intron features and identified spliceosomal RNA/protein components. We found that all snRNAs are present, whereas many proteins are conserved but slightly reduced in size. Some regulators such as Serine/Arginine-rich proteins are noticeably undetected. Interestingly, while most parts of spliceosomal proteins, including Prp8’s positively-charged catalytic cavity, are conserved, regions of branching factors projecting to the active site are not. We conjecture that steric-clash avoidance between spliceosomal proteins and a sharply-looped lariat might occur and splicing regulation may differ from other species.
Radiation-induced fibrosarcoma after breast-conserving surgery and radiation therapy for breast cancer: A case report and literature review
Authors: Hoshina Hideko , Kubouchi Kouichi , Tsutsumi Yutaka , Takei Hiroyuki 
Published: July 2022

Abstract
Background: Radiation-induced sarcoma (RIS) has a 10-year incidence of 0.2-0.27% and a poor prognosis. In particular, radiation-induced fibrosarcoma has been rarer, and its incidence is 2.6-3.7% of RIS.Case presentation: A 43-year-old woman with pT1N1M0 breast cancer underwent breast-conserving surgery, chemotherapy, radiation therapy eight years ago, and continued hormonal therapy. She complained of a hard mass palpated in her right axillary breast. Although we suspected local recurrence, core needle biopsy revealed atypical spindled tumor cells without mammary or epithelial markers. A diagnosis of fibrosarcoma was made via tumorectomy. She underwent additional enlarged surgery.Conclusions: We report a rare case of fibrosarcoma after breast-conserving surgery and radiation therapy. Fibrosarcoma after radiation therapy for breast cancer has been reported in 30 cases, including the present case. The dead and alive cases were not significantly different in terms of age, primary breast cancer, radiation dose, and following months. Patients with breast masses after radiation therapy should be suspected local recurrence and RIS.
Extraction and generalisation of category-level information during visual statistical learning in autistic people
Authors: Parsons Owen , Baron-Cohen Simon 
Published: July 2022

Abstract
Background We aimed to assess whether autistic individuals were able to generalise across contexts when building statistical expectations of their environment to the same extent as non-autistic individuals. We did this by assessing the implicit awareness of statistical regularities in a sequence of naturalistic scene images in both autistic and non-autistic individuals. Methods125 participants (61 participants with an autism diagnosis and 64 non-autistic controls) were presented with a fast serial presentation sequence of images and given a cover task to avoid attention being explicitly drawn to patterns in the underlying sequences. This was followed by a two-alternative forced choice task to assess participants’ implicit recall. Participants were presented with 1 of 3 unique versions of the task, in which the presentation and assessment of statistical regularities was done at either a low feature-based level or a high semantic-based level. ResultsThere were no significant group differences in how performance varied across the 3 conditions, but there was an overall significant reduction in visual statistical learning in the autistic group. There was also a lack of statistical significant effect of learning for the autistic participants who completed the generalisation condition.LimitationsWhile the overall sample was fairly large, the sample sizes for the subgroups within the study were modest, so the lack of statistically significant effect of learning for the autistic participants who completed the generalisation condition may be due to a lack of power rather than a true absence of learning. Additionally, this study did not directly assess if semantic information was being processed to a similar extent by both autistic and non-autistic participants.ConclusionsThese results do not support the claim that autistic individuals experience difficulties in either acquiring or generalising statistic regularities at the category-level, but suggest that differences in visual statistical learning occur in autistic people.
Reflective functioning in children and their caregivers during the COVID-19 pandemic
Authors: Costa-Cordella Stefanella , Rossi Alejandra , Sieverson Catalina , Grasso-Cladera Aitana , Badilla María Paz , Borgeaud Karin , León María Jose , Mora Simone Charpentier , Bizzi Fabiola 
Published: July 2022

Abstract
BackgroundThe emergence of COVID-19 has brought global awareness to the impact of the pandemic on mental health. Public health measures such as school closures and lockdowns led to overburdening both in children and their caregivers and increased emotional and behavioral problems, especially in low-income families.More work exploring families’ reflective functioning (RF)- the capacity to understand our own and others’ mental states- might help us understand the processes associated with mental health concerns in children and adolescents living with economic hardship.ObjectivesIn a sample of economically vulnerable caregiver-child dyads, the current study explored the relationship between parental and child RF, and the perceived stress levels of the caregiver and child during the COVID-19 pandemic.MethodThe study utilized Pearson’s correlation on four instruments: the Child Attachment Interview and Parent Development Interview to evaluate the level of parental and child RF; plus, the Stress in Children Questionnaire and and Perceived Stress Scale to assess the levels of stress of each member of the dyad.ResultsAs expected, the RF levels of the caregiver and child were positively correlated. However, no association was found between the RF of either child or caregiver and their levels of perceived stress.ConclusionsDespite limitations, the present findings may have important implications for interventions, specifically those designed to improve parenting RF, which positively affects children’s mental health. Therefore, our findings highlight the potential of providing interventions based on parental RF to this population.
PACADI - Translation and adaptation of a Swedish-language version of the Pancreatic Cancer Disease Impact score
Authors: Andersson Thomas Karl-Axel , Olsén Monika Fagevik , Nouh Micheline Al , Bratlie Svein Olav 
Published: July 2022

Abstract
ObjectiveThe Norwegian Pancreatic cancer disease impact score (PACADI) is a digitalized analogue questionnaire that assesses different disease-specific symptoms. There is a need of translations of it into other languages. Therefore, the aim of this article is to describe the translation process of a Swedish version of PACADI and present its validity to EORCT QLQ PAN26.The self-administered questionnaire PACADI was translated according to guidelines and assessed by an expert panel of health care personnel. The test of its validity was performed with the disease-specific questionnaire for EORCT QLQ PAN26. Both questionnaires were completed by 66 subjects with pancreatic cancer, either before, at discharge or three months after surgery. Result The results between the groups indicate that patients suffer from different symptoms at different times. The correlations between the different symptoms of the two questionnaires were fair to good. In conclusion, PACADI and QLQ PAN 26 have a good correlation and PACADI can be used in clinical practise.
The first two years of COVID-19 in Italy: Incidence, lethality, and health policies
Authors: ferrante Pierpaolo 
Published: July 2022

Abstract
Background
The novel coronavirus disease is an ongoing pandemic that started in China in December 2019. The aim of this paper is to provide a detailed overview of the first two years of this pandemic in Italy.
Design and methods
: Using the negative binomial distribution, we estimated the daily incidence of infections from the virus lethality and the resulting deaths (estimated by weighted moving average). We adjusted the daily lethality of the original strain (estimated through national sero-surveys) for age, hazard ratios of virus variants of concern and the cumulative distribution of vaccinated people.
Results
From the 24th of February 2020 to the 28th of February 2022, we estimated 20,833,018 (20,728,924 − 20,937,375) cases distributed over 5 waves. The overall lethality was 0.73% and daily ranged from 2.78% (in the first wave) to 0.15% (in the last one). The first two waves showed the highest daily peaks of deaths (about 710), the last one showed the highest daily peak of infections (220,487). Restriction measures of population mobility strongly slowed the virus’s spread. During the second pandemic year, vaccines prevented 10,000,000 infections and 115,000 deaths.
Conclusion
In the summer, the main mode of transmission was presumably direct contact. A massive test campaign allowed monitoring of the virus’ spread, especially among the younger population. Mobility restriction measures are effective in a suppression strategy; distance learning and smart working are effective in a mitigation strategy. Despite the variants of concern, vaccines strongly reduced the pandemic impact on the healthcare system and avoided strong restriction measures.
Impact of total radiation dose on treatment outcomes of radiotherapy and concomitant superselective intra-arterial high-dose cisplatin in localized maxillary sinus cancer
Authors: Konishi Kenta , Kamiya Mika , Ohira Keiichi , Hirata Masanori , Wakabayashi Kohei , Ikenohira Tsutomu , Kosugi Takashi , Ushio Takasuke , Imai Atsushi , Mochizuki Daiki , Yamaguchi Yuki , Tanahashi Yukichi , Misawa Kiyoshi , Goshima Satoshi , Nakamura Katsumasa 
Published: July 2022

Abstract
Background
We investigated the efficacy of superselective intra-arterial infusion of high-dose cisplatin (CDDP) with concomitant radiotherapy (RADPLAT) using three-dimensional conformal radiotherapy (3DCRT) or intensity-modulated radiotherapy (IMRT), and we analyzed the relationship between the total radiation dose and the treatment outcome in localized maxillary sinus cancer.
Methods
We examined the cases of 58 patients with localized maxillary sinus cancer who were treated with RADPLAT at our institution from March 2004 to November 2020. These 58 patients include 34 who received 3DCRT and 24 who have received IMRT.
Results
The median follow-up period was 38.4 months. The median prescribed dose to the local lesion was 66 Gy in the 3DCRT group and 70 Gy in the IMRT group. CDDP (100–120 mg/m2) were administered with a median of 6 cycles once a week. The 5-year local control rate and overall survival rate were 69.9% and 72.2%, respectively. The patients who were treated with 70 Gy had significantly higher local control rate (87.7%) than the patients treated with 60 Gy or lower (41.0%) (p = 0.011).
Conclusions
The patients who had received 70 Gy using IMRT had significantly higher local control rate. The total dose may have an impact on the local control rate in RADPLAT.
GhBES1 mediates brassinosteroid regulation of leaf size by activating expression of GhEXO2 in cotton (Gossypium hirsutum)
Authors: Li Shengdong , Xing Kun , Qanmber Ghulam , Chen Guoquan , Liu Le , Guo Mengzhen , Hou Yan , Lu Lili , Qu Lingbo , Liu Zhao , Yang Zuoren 
Published: July 2022

Abstract
Brassinosteroid (BR) is an essential phytohormone that controls plant growth. However, the mechanisms of BR regulation of leaf size remain to be determined. Here, we found that the BR deficient cotton mutant pagoda1 (pag1) had a smaller leaf size than wild-type CRI24. The expression of EXORDIUM (GhEXO2) gene, was significantly downregulated in pag1. Silencing of BRI1-EMS-SUPPRESSOR 1 (GhBES1), inhibited leaf cell expansion and reduced leaf size. Overexpression of GhBES1.4 promoted leaf cell expansion and enlarged leaf size. Expression analysis showed GhEXO2 expression positively correlated with GhBES1 expression. In plants, altered expression of GhEXO2 promoted leaf cell expansion affecting leaf size. Furthermore, GhBES1.4 specifically binds to the E-box elements in the GhEXO2 promoter, inducing its expression. RNA-seq data revealed many down-regulated genes related to cell expansion in GhEXO2 silenced plants. In summary, we discovered a novel mechanism of BR regulation of leaf size through GhBES1 directly activating the expression of GhEXO2.
Psychometric evaluation of the subjective well-being measure GP-CORE in a group of older adults in Sweden
Authors: Hochwälder Jacek , Gustafsson Lena-Karin , Östlund Gunnel , Zander Viktoria , Anbäcken Els-Marie , Elfström Magnus 
Published: July 2022

Abstract
Background: The world’s growing population of older adults is one population that needs to be focused more regarding subjective well-being. It is therefore important to evaluate self-report instrument that measures general well-being for this specific group - older adults. The aim of the present study was to investigate psychometric properties of the Swedish translation of the GP-CORE (general population – Clinical Outcomes in Routine Evaluation) in a group of older adults (> 65 years).Methods: In this study, a psychometric evaluation of the GP-CORE is presented for 247 Swedish older adults (> 65 years), 184 women and 63 men who applied for home care assistance for the first time. Results: The psychometric evaluation showed high acceptability; provided norm values in terms of means, standard deviations and quartiles; showed satisfactory reliability in terms of both internal consistency and stability; showed satisfactory validity in terms of convergent and discriminant validity; provided a very preliminary cut-off value and quite low sensibility and sensitivity and showed results which indicated that this scale is sensitive to changes. One gender difference was identified in that women without a cohabitant had a higher well-being than men without a cohabitant (as measured by GP-CORE).Conclusions: The GP-CORE showed satisfactory psychometric properties to be used to measure and monitor subjective well-being in older adults (> 65 years) in the general population of community dwelling. Future studies should establish a cut-off value in relation to another well-being measure relevant for mental health in older adults.
Transcriptomic analysis of PBMCs reveals COX3, BCL2, ATP2B4, B4GALT1, LACTB, FASN and CSN family genes regulating milk performance in lactating Bos indicus cows of Southern India
Authors: Nizamuddin Azharuddin , Ramesha Kerekoppa P , Rana Ekta , Kasargod Sandeep , Behera Santosh Kumar , Ashokan Manokaran , Patil Arun H , Jeyakumar Sakthivel , Kumaresan Arumugam , Kataktalware Mukund Amritrao , Das Dayal Nitai , Srinisva Naveen Kumar Gowribidanur , Prasad Thottethodi Subrahmanya Keshava 
Published: July 2022

Abstract
The expression of genes related to lactogenesis in peripheral blood mononuclear cells (PBMCs) are less understood. To understand the biology of milk production in early lactating non pregnant cows in the blood, the transcriptome from PBMCs was analysed by RNA sequencing. We are able to generate a total of ~ 62.5 Gbp RNA-Seq data files (~ 24 million to ~ 35 million paired-end reads per sample) from high yielder (3) and low yielder (3) of Deoni and Hallikar breeds of Bos indicus (12 samples). The blood sample was collected from twelve early lactating non pregnant cows, the transcriptome from PBMCs was analysed by RNA sequencing. The QC passed reads were aligned against Bos taurus reference assemblies by using HiSAT2 alignment tool. An average of 79.25% and 74.28% reads were aligned in Deoni and Hallikar breeds, respectively. Amongst 85 genes were significantly differentially regulated between low yielder and high yielder of Deoni cows. On contrary, in Hallikar 492 genes were significantly differentially regulated between groups. Transcripts related to CSN gene family (CSN1S1, CSN1S2, CSN2 and CSN3) and FASN were significantly expressed in High yielders of Deoni cows. However, in low yielding Deoni cows and all Hallikar cows, these CSN gene family and FASN gene expression levels were poor or not at all expressed. However, the ATP2B4 (PMCA - Plasma membrane Ca2 + ATPase) gene is expressed only in Hallikar cows. Majority of the genes in lactating Deoni and Hallikar cows were linked to milk protein composition especially caseins, milk fat, lactose synthesis in milk and apoptosis activity in mammary glands. Our findings provide new insights into the understanding of molecular mechanism of differential milk yield among Bos indicus breeds. We believe that our study would be helpful in lactation biology and genetic selection.
Cd3 Epsilon Immune Restorative Ability Induced by Maitake Pro4x in Immunosupressed Balbc Mice.
Authors: Aguilera-Braico Diego Maximo , Balogh Gabriela Andrea 
Published: July 2022

Abstract
Objectives: The aim of this research was to determine if the rich beta glucan compound called Maitake Pro4X can recover the T cell/NK population depleted by Dexamethasone treatment in lymph nodes from cancer-free BALBc female mice. A CD3Ɛ molecular FITC labelled marker was used to measure the effect of Maitake D-Fraction Pro4X (5mg/Kg) on T cell/NK cells populations employing flow cytometry from immunosuppressed female BALBc mice in lymph nodes. There were employed other molecular markers such as CD19, CD105, Ly6G.Results: Maitake Pro4X (5mg/Kg) was able to recover 42.97% of the depleted CD3Ɛ FITC cell population level in Lymph nodes from immunosuppressed female BALBc mice from 4.328 ± 6.229 to 22.646 ± 12.393 (p<0.01) using Flow Cytometry. Maitake was also able to significantly increase the Ly6G PE cell population with p<0.05 in lymph nodes.
Clustering of 2D maps based on similarity in DFT‑calculated vs experimental 13C‑15N spin couplings for a representative sample of conformationally rigid and structurally fixed nitrogen‑containing compounds.
Authors: Stanishevskiy Vladislav V. , Shestakova Alla K. , Chertkov Vyacheslav A. 
Published: July 2022

Abstract
Nitrogen is an essential element involved in many interactions in living chemistry, the formation of hydrogen bonds, participation in the acidbase balance in vital systems. It plays a key role in the construction of a huge number of organic and natural compounds. Currently, structural studies of nitrogen-containing compounds require new approaches based on increasingly accurate and proven methods. In this connection, the constants of the spin-spin interaction with 15N nuclei seem to be very promising. In this work, we carried out an extended verification of the 13C15N spinspin coupling constants as a new structural indicator of nitrogen-containing compounds. In this regard, we performed a quantum-chemical calculation of a set of 193 spin-spin coupling values (B3LYP with basis functions 6-311 + + G(2df,2p)) for the set of all currently known conformationally rigid and structurally fixed nitrogen-containing compounds. Comparison of theoretical relationships with experimental ones shows a statistically significant good or excellent agreement. A parallel analysis of the variability of the calculated values of 13C15N spin bonds with the variability of experimental data within groups of related compounds turned out to be practically useful. Such an approach can provide important information for the unambiguous assignment of the 13C peaks and for determining the signs of the 13C15N spinspin coupling constants in cases where they have not previously been established experimentally.