bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of a Perfusion Balloon for Intraprocedural Stent Thrombosis in a Patient With ST-Segment Elevated Myocardial Infarction Complicated With Cardiogenic Shock
Authors: Takeyama Taro , Mizutani Yukiko , Ishikawa Tetsuya , Yamada Kota , Nakamura Hidehiko , Nakahara Shiro , Taguchi Isao 
Published: December 2022

Intraprocedural stent thrombosis is a rare but serious complication of reperfusion therapy for acute coronary syndrome. There is currently no consensus on the intraprocedural management of intraprocedural stent thrombosis. It is difficult to attain thrombolysis in myocardial infarction flow grade 3, particularly in cases of cardiogenic shock.
A 49-year-old man who presented with anterior ST-segment elevated acute myocardial infarction with cardiogenic shock underwent emergency percutaneous coronary intervention to diffuse proximal lesions in the left anterior descending artery under the support of intra-aortic balloon pumping. Intraprocedural stent thrombosis occurred following the postdilations with a 3.5- × 38-mm everolimus-eluting stent. Despite administration of argatroban and nitroprusside, and after frequent balloon inflations using 3.5-mm noncompliant balloons and thrombectomy, the no-reflow phenomenon was repetitively established. However, after brief and prolonged balloon inflations using 3.5- and 3-mm Ryusei perfusion balloon catheters (Kaneka Medix), the diffusely protruded thrombus inside the stent regressed, and thrombolysis in myocardial infarction flow grade 3 was obtained. The final intravascular ultrasound image showed a well-suppressed, in-stent thrombus and 24% gain of stent area (from 7.5 to 9.3 mm2).
A Ryusei perfusion balloon enabled frequent, long inflation times without deteriorating hemodynamics during reperfusion in ST-segment elevated acute myocardial infarction complicated with cardiogenic shock. Thus, extended balloon inflation using a perfusion balloon is deemed a viable option not only for intraprocedural stent thrombosis but also for cases with a high burden of thrombi during the primary stenting procedure for patients with acute coronary syndrome.
Evaluation of ichroma™ COVID-19 interferon gamma release assay for detection of vaccine-induced immunity in healthcare workers
Authors: Lim Yong Kwan , Kweon Oh Joo , Choi Yoojeong , Kim Tae-Hyoung , Lee Mi-Kyung 
Published: December 2022

Abstract

Objectives
We compared the performance of a new interferon gamma release assay (IGRA) format assay, the ichroma™ COVID-19 IGRA (IGRA-SARS), with that of the widely used QuantiFERON SARS-CoV-2 ELISA kit (QFN-SARS) in vaccinated healthcare workers (HCWs). Additionally, we analyzed the long-term changes in IGRA results after the final vaccine dose.

Methods
A total of 383 specimens from 281 HCWs were enrolled in this study, and the results of SARS-IGRA and QFN-SARS assays were compared. In addition, we performed the receive operator curve analysis to estimate the optimal cut-off value for IGRA-SARS.

Results
For all specimens, IGRA-SARS and QFN-SARS showed 75.7% and 64.2% of the positive results, respectively. The absolute agreement between IGRA-SARS and QFN-SARS was 80.0%, and the Fleiss’ κ value was 0.525, indicating moderate agreement. ROC curve analysis of the IGRA-SARS results showed a cut-off value of >0.254 IU/mL, which was consistent with the manufacturer’s specifications. The positive rates of both IGRA assays decreased significantly after a postvaccination period of 6 months.

Conclusions
IGRA-SARS showed acceptable performance in the detection of vaccine-induced immunity against COVID-19; however, harmonization of IGRA assays has not yet been achieved. Additionally, the significant decline of positive rates of IGRA after the last vaccination would support the necessity of booster vaccination after a postvaccination period of 6 months.
Association of VKORC1 and CYP2C9 single-nucleotide polymorphisms with warfarin dose adjustment in Saudi patients
Authors: Holail Jasmine , Mobarak Reem , Al-Ghamdi Bandar , Aljada Ahmad , Fakhoury Hana 
Published: December 2022

Abstract

Objectives
Despite its wide usage, warfarin therapy remains challenging due to its narrow therapeutic index, inter-individual response variability, and risk of bleeding. Previous reports have suggested that polymorphisms in VKORC1 and CYP2C9 genes could influence warfarin therapy. Herein, we investigated whether VKORC1 −1173C>T, CYP2C9*2, and CYP2C9*3 gene polymorphisms are associated with warfarin dose adjustment and related bleeding events.

Methods
This cross-sectional study was conducted on Saudi adults receiving warfarin for more than 1 month. Their demographics and relevant clinical data were obtained. Genotyping for VKORC1 −1173C>T, CYP2C9*2, and CYP2C9*2 genotypes was performed.

Results
Patients who are homozygous for the mutant T allele VKORC1 T/T required the lowest warfarin daily maintenance dose, compared to VKORC1 C/T and VKORC1 C/C. Similarly, there was a significant reduction in warfarin daily maintenance dose among CYP2C9*1/*3 and CYP2C9*1/*2 groups compared to CYP2C9*1/*1. However, we found no significant correlation between the studied polymorphisms and warfarin-associated bleeding.

Conclusions
Similar to other populations, the VKORC1 and CYP2C9 gene polymorphisms are significantly associated with warfarin dosage in Saudi patients. The presence of at least one copy of the mutant alleles for VKORC1 −1173C>T, CYP2C9*2, and CYP2C9*3 is associated with a significant reduction in warfarin maintenance dose.
Cerebrospinal fluid lactate as a predictive biomarker for tuberculous meningitis diagnosis
Authors: de Almeida Sérgio Monteiro , Kussen Gislene B. , Cogo Laura L. , Nogueira Keite 
Published: December 2022

Abstract

Objectives
The definitive diagnosis of tuberculous meningitis (TBM) is achieved by identifying Mycobacterium tuberculosis (MTb) in cerebrospinal fluid (CSF); however, diagnostic confirmation is difficult due to the inability of current tests for an effective diagnosis. Our objective was to retrospectively assess the characteristics of CSF lactate (CSF-LA) as an adjunct biomarker in the diagnosis of TBM.

Methods
608 CSF laboratory reports were assessed. Of these, 560 had clinically suspected TBM. These were classified as definite (n=36), probable (23), possible (278), or non-TBM (223) according to the international consensus TBM case definitions. An additional 48 CSF samples were negative controls with normal CSF.

Results
Against a reference standard of definite TBM, the cut-off value for CSF-LA was 4.0 mmol/L, the area under the ROC curve was 0.88 (95% CI, 0.82–0.94; p=0.0001), sensitivity was 69%, specificity 90%, negative predictive value 98%. These diagnostic parameters decreased when calculated against those of the other categories of TBM. CSF-LA exhibited high specificity, efficiency, negative predictive value, and clinical utility index in all the groups studied.

Conclusions
CSF-LA is a useful diagnostic marker to rule out TBM when associated with conventional microbiology tests, nucleic acid amplification assays, and clinical algorithms, particularly in endemic areas.
Non-finite verb forms in Turkic exhibit syncretism, not multifunctionality
Authors: Washington Jonathan N. , Tyers Francis M. , Salimzianov Ilnar 
Published: December 2022

Abstract
Non-finite verbs in Turkic are typically categorised as participles, converbs, and sometimes infinitives, with multiple uses of a form within one category considered to constitute multiple functions. This multifunctionality approach predicts that all non-finite verb forms within each of the categories should have the same range of syntactic functions. We show that this is not the case. Based on analysis of a representative set of Turkic languages (Kazakh, Kyrgyz, Sakha, Tatar, Turkish, and Tuvan), we propose a categorisation based on morphological and syntactic properties of non-finite verbs, resulting in four categories: verbal nouns, verbal adjectives, verbal adverbs, and infinitives. Under this approach, forms that are typically labelled as participles end up categorised as verbal nouns, verbal adjectives, or both, and forms that are typically labelled as converbs end up categorised as verbal adverbs, infinitives, or both. Some forms even span these two divisions. When a non-finite verb form appears to exist in multiple categories, we consider this to be a case of syncretism; this is, there is a member of one category that has the same form as a member of another category. We propose historical trajectories that may have led to the types of situations that are attested, examine the limitations of this approach, and discuss its wider implications.
The effect of linguistic choices in note-taking on academic listening performance: a pedagogical translanguaging perspective
Authors: Zhou Xiaozhou (Emily) , Chen Xinran , Wang Ziyang 
Published: December 2022

Abstract
The inherent complexity of listening activities poses considerable challenges to second language listeners. For decades, researchers have been exploring effective strategies to help improve L2 learners’ listening proficiency. Note-taking, which is frequently and strategically employed to complete listening tasks and to learn content, has also been examined extensively from various perspectives. However, it seems that little is known about the effect of L2 learners’ linguistic choices in note-taking on their listening performance. Employing pedagogical translanguaging as an analytical lens, the current research sets out to investigate whether or not L2 learners’ multilingual notes, compared to monolingual notes, significantly enhance their performance in academic listening activities. Conducted in a Chinese university EFL context, this study adopts a mixed-methods approach. A total of 90 participants were assigned to three groups and were asked to take notes in Chinese, English, and a combination of all languages, symbols, drawings, etc., respectively. Data were collected from the results of two listening tasks (a listening comprehension test and a retelling task), a questionnaire survey designed to focus on their attitudes to the linguistic choices they made in note-taking, and the multilingual notes taken. The findings revealed that students who were allowed to make full use of their linguistic and semiotic resources in note-taking were able to perform significantly better in both listening tasks. The same group of students also demonstrated a diverse and flexible mobilization of their multilingual and multimodal assets in the notes they took. This study provides evidence for applying pedagogical translanguaging as an effective approach in designing note-taking instructions. It is suggested that L2 learners should be encouraged to deploy their entire linguistic repertoire when taking notes during listening activities, which could lead to improved performance.
A word-based account of comprehension and production of Kinyarwanda nouns in the Discriminative Lexicon
Authors: van de Vijver Ruben , Uwambayinema Emmanuel 
Published: December 2022

Abstract
Are the cognitive units in the mental lexicon of Bantu speakers words or morphemes? The very small experimental literature addressing this question suggests that the answer is morphemes, but a closer look at the results shows that this answer is premature. A novel theory of the mental lexicon, the Discriminative Lexicon, which incorporates a word-based view of the mental lexicon, and is computationally implemented in the Linear Discriminative Learner (LDL) is put to the test with a data set of 11,180 Kinyarwanda nouns, and LDL is used to model their comprehension and production. LDL predicts comprehension and production of nouns with great accuracy. Our work provides support for the conclusion that the cognitive units in the mental lexicon of Kinyarwanda speakers are words.
Analysis of a deteriorating system with delayed repair and unreliable repair equipment
Authors: Li Yan-Ling , Xu Gen Qi , Chen Hao 
Published: December 2022

Abstract
In this article, we mainly consider a repairable degradation system consisting of a single component, a repairman, and repair equipment. Suppose that the system cannot be repaired immediately after failure and cannot be repaired “as good as new.” Herein, the repair equipment may fail during repair and the system will replace a new one after failures. In particular, the repair time follows the general distribution. Under the above assumptions, a partial differential equation model is established through the geometric process and supplementary variable technique. By Laplace transform, we obtain the availability of the system, and from the expression one can see that the availability of the system will tend to zero after running for a long time. Therefore, we further study a replacement policy

N

N

based on the failed times of the system. We give the explicit expression of the system average cost

C

(

N

)

C\left(N)

and obtain the optimal replacement policy

N

∗

{N}^{\ast }

by minimizing the average cost rate

C

(

N

∗

)

C\left({N}^{\ast })

. That is, the system will be replaced when the failure number of the system reaches

N

∗

{N}^{\ast }

. Furthermore, the extended degenerate system is proposed by assuming that the system is not always successive degenerative after repair, and then the optimal replacement policy is studied. Finally, the numerical analysis is given to illustrate the theoretical results.
Compact mappings and s-mappings at subsets
Authors: Lin Shou , Ling Xuewei , He Wei 
Published: December 2022

Abstract
Almost

s

s

-mappings and almost compact mappings have been introduced and studied. In this article, we continue to research some questions related to the almost s-images (resp., almost compact images) of metric spaces. The following results are obtained. (1) A space

X

X

is a quotient and almost compact image of a metric space if and only if

X

X

is a sequential space having a

c

s

∗

c{s}^{\ast }

-network which is point-regular at nonisolated points, which gives an affirmative answer to Question 4.9 in the article “S. Lin, X. W. Ling, and Y. Ge, Point-regular covers and sequence-covering compact mappings, Topology Appl. 271 (2020), 106987.” (2) There exists a bi-quotient and almost compact image of a metric space satisfying no base, which is point-countable at nonisolated points, which gives negative answers to Question 3.1 in the article “X. W. Ling and S. Lin, On open almost s-images of metric spaces, Adv. Math. (China) 48 (2019), no. 4, 489–496” and Question 3.7 in the article “X. W. Ling, S. Lin, and W. He, Point-countable covers and sequence-covering s-mappings at subsets, Topology Appl. 290 (2021), 107572.” (3) Some characterizations of countably bi-quotient and almost

s

s

-images (resp., pseudo-open and almost compact images) of metric spaces.
Graphene-oxide-reinforced cement composites mechanical and microstructural characteristics at elevated temperatures
Authors: Han Seungyeon , Hossain Mohammad Shakhawat , Ha Taeho , Yun Kyong Ku 
Published: December 2022

Abstract
The focus of this research was to investigate the effects of graphene oxide (GO) on the microscopic composition, structure, pore size, and mechanical properties of GO-reinforced cement composites. Furthermore, the research explored the thermal behavior of GO-reinforced cement mortar at different elevated temperatures (250, 500, 750, and 1,000°C). This study considered three sets of GO-reinforced cement composites with 0.1, 0.2, and 0.3 wt% of GO (by weight of cement); the water–cement ratio in all the mixtures was 0.5. To characterize the chemical composition, microstructure, and hydration degree resulting from GO addition, X-ray diffraction, thermogravimetry, derivative thermogravimetry, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and micro-computed tomography (Micro-CT) were used. The experimental results revealed that GO addition changed the microstructural composition and pore diameter distribution of the cement composite. The optimal amount of GO required for improving the mechanical properties of the cement composite under both unheated and heated conditions was identified to be 0.1 wt%. GO improves the cement matrices’ ability to bind with GO nanosheets, leading to compressive strength retention and decreased micro-cracking (computed by material and defected volume changes by Micro-CT analysis). This is primarily due to the hydration products. However, the optimal amount of GO can result in nanomaterial agglomeration, thus lowering the thermal resistance of the cement composite. Overall, the study identified GO as a nano-additive with the potential to improve the strength and toughness of the cement composites. Moreover, the effect of elastic modulus was also evaluated. As a result, the GO microstructure analysis revealed that it has a porous structure with a visible crack pattern.
Sustained oxygen release of hydrogen peroxide-acrylic resin inclusion complex for aquaculture
Authors: Ma Chenghong , Zhang Shulin , Cong Fangdi , Xu Yanling , Zhang Jingjing , Zhang Dajuan , Zhang Liwang , Su Yongpeng 
Published: December 2022

Abstract
To overcome the lack of dissolved oxygen in high-density aquaculture water, a hydrogen peroxide-acrylic resin inclusion complex with sustained oxygen releasing effect was designed and prepared. The resin was synthesized by emulsion polymerization of acrylic acid, methyl methacrylate and butyl acrylate in a mass ratio of 2: 3: 5, and neutralized with sodium hydroxide solution by 50%. The resin solution was mixed in a mixture of urea and 30% hydrogen peroxide solution (CO(NH2)2: H2O2, 1: 1, mol: mol), and dried at 40 °C for 4 h to obtain the hydrogen peroxide-acrylic resin inclusion complex. The product with 4.0% resin by mass of hydrogen oxygen solution, could release oxygen for 92 h in pond water. After optimization by adding a small amount of NaCl, Na2SO4, and EDTA, it was mixed with calcium carbonate and magnesium stearate in a mass ratio of 5: 4: 0.9, and pressed into tablets (1.2 × 0.6 cm, 0.99 g). One tablet in 50 L simulated micro ecosystem aquaculture water with 20 of Carassius auratus fish could release oxygen for 116 h and brought fish with 83.3% of survival rate higher than 51.7 and 70.0% of blank and sodium percarbonate groups.
Reducing component stress during encapsulation of electronics: a simulative examination of thermoplastic foam injection molding
Authors: Ott Constantin , Drummer Dietmar 
Published: December 2022

Abstract
The direct encapsulation of electronic components is an effective way of protecting components against external influences. In addition to achieving a sufficient protective effect, there are two other big challenges for satisfying the increasing demand for encapsulated circuit boards. The encapsulation process should be both suitable for mass production and offer a low component load. Injection molding is a method with good suitability for large series production but also with typically high component stress. In this article, two aims were pursued: first, the development of a calculation model that allows an estimation of the occurring forces based on process variables and material parameters. Second, the evaluation of a new approach for stress reduction by means of thermoplastic foam injection molding. For this purpose, simulation-based process data was generated with the Moldflow simulation tool. Based on this, component stresses were calculated with the calculation model. The suitability of the new approach was clearly demonstrated and a significant reduction in shear forces during overmolding was achieved. It was possible to demonstrate a process development that makes it possible to meet the two main requirements of direct encapsulation in addition to a high protective effect.
Location-specific labour control strategies in online retail
Authors: Fuchs Martina , Dannenberg Peter , López Tatiana , Wiedemann Cathrin , Riedler Tim 
Published: December 2022

AbstractOnline retail is currently profoundly restructuring the working conditions in the retail sector. Existing studies generally describe the working conditions in the large warehouses of online retail as ‘digital Taylorism’. This article broadens this perspective and draws on the theoretical concept of the local labour control regime. It explores how managements’ technological and social labour control strategies vary spatially between online retail warehouses located in inner and outer metropolitan areas of the four largest German cities. The study uses qualitative methods and is mainly based on expert interviews with executives, representatives of trade unions and works councils, representatives of associations, and further experts. This study gains insights on the spatial variety of labour control and thus is relevant for international research on labour control and for practitioners’ ability to create decent and humane work.
Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development
Authors: Xiao Yue , Chen Jiehui , Yang Suming , Sun Honghua , Xie Lele , Li Jinsong , Jing Naihe , Zhu Xueliang 
Published: December 2022

AbstractEarly embryonic development depends on proper utilization and clearance of maternal transcriptomes. How these processes are spatiotemporally regulated remains unclear. Here we show that nuclear RNA‐binding protein Rbm14 and maternal mRNAs co‐phase separate into cytoplasmic condensates to facilitate vertebrate blastula‐to‐gastrula development. In zebrafish, Rbm14 condensates were highly abundant in blastomeres and markedly reduced after prominent activation of zygotic transcription. They concentrated at spindle poles by associating with centrosomal γ‐tubulin puncta and displayed mainly asymmetric divisions with a global symmetry across embryonic midline in 8‐ and 16‐cell embryos. Their formation was dose‐dependently stimulated by m6A, but repressed by m5C modification of the maternal mRNA. Furthermore, deadenylase Parn co‐phase separated with these condensates, and this was required for deadenylation of the mRNAs in early blastomeres. Depletion of Rbm14 impaired embryonic cell differentiations and full activations of the zygotic genome in both zebrafish and mouse and resulted in developmental arrest at the blastula stage. Our results suggest that cytoplasmic Rbm14 condensate formation regulates early embryogenesis by facilitating deadenylation, protection, and mitotic allocation of m6A‐modified maternal mRNAs, and by releasing the poly(A)‐less transcripts upon regulated disassembly to allow their re‐polyadenylation and translation or clearance.
De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases
Authors: Karvounis Evangelos , Zoupas Ioannis , Bantouna Dimitra , Paparodis Rodis D , Efthymiadou Roxani , Ioakimidou Christina , Panopoulos Christos 
Published: December 2022

Summary
Large-cell neuroendocrine carcinoma (LCNEC) is a rare neuroendocrine prostatic malignancy. It usually arises after androgen deprivation therapy (ADT), while de novo cases are even more infrequent, with only six cases described. The patient was a 78-year-old man with no history of ADT who presented with cervical lymphadenopathy. Diagnostic approaches included PET/CT, MRI, CT scans, ultrasonography, biopsies, and cytological and immunohistochemical evaluations. Results showed a poorly differentiated carcinoma in the thyroid gland accompanied by cervical lymph node enlargement. Thyroid surgery revealed LCNEC metastasis to the thyroid gland. Additional metastases were identified in both the adrenal glands. Despite appropriate treatment, the patient died of the disease. De novo LCNEC of the prostate is a rare, highly aggressive tumor with a poor prognosis. It is resistant to most therapeutic agents, has a high metastatic potential, and is usually diagnosed at an advanced stage. Further studies are required to characterize this tumor.

Learning points

De novo LCNECs of the prostate gland can metastasize almost anywhere in the body, including the thyroid and adrenal glands.

LCNECs of the prostate are usually associated with androgen-depriving therapy, but de novo cases are also notable and should be accounted for.

Further studies are required to fully understand and treat LCNECs more effectively.