bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-fidelity Design Optimization and Development of a VTOL Swarm UAV using an Open-source Framework
Authors: Sethi Nikhil , Ahlawat Saurav 
Published: January 2022

Abstract
Hybrid configurations in aircraft design are highly favorable as they can achieve the appropriate trade-offs required to develop a generalized unmanned aerial system. Rapid prototyping of such systems at the student level is a challenge because commercial software is expensive and difficult to interlink with other tools for creating a multi-disciplinary design. In this paper, an all-electric unmanned aerial system with both Vertical Takeoff and Landing (VTOL) and Fixed-Wing (FW) capabilities is designed and optimized for long range surveillance and relief operations. The entire design and simulation pipeline from concept to render is done using completely open-source software, libraries and in-house code. The Unmanned Aerial Vehicle (UAV) is equipped with on-board computers and sensors, and is designed to operate in an ad-hoc WiFi network with a swarm of similar UAVs. A prototype is fabricated, integrated and tested as well. A comparison with commercial codes and programs is done parallel to each design step. The study is concluded by discussing the primary challenges of using free software and testing a UAV with a hybrid configuration.
Nanocarrier System for Increasing the Therapeutic Efficacy of Oxaliplatin
Authors: Alavi Negin , Rezaei Majid , Maghami Parvaneh , Fanipakdel Azar , Avan Amir 
Published: January 2022

Abstract:
The application of Oxaliplatin (OxPt) in different malignancies is reported to be accompanied
by several side effects, including neuropathy, nausea, vomiting, diarrhea, mouth sores, low
blood counts, loss of appetite, etc. The passive or active targeting of different tumors can improve
OxPt delivery. Considering the demand for novel systems meant to improve the OxPt efficacy and
define the shortcomings, we provided an overview of different approaches regarding the delivery
of OxPt. There is an extending body of data that exhibits the value of liposomes and polymer-
based drug delivery systems as the most successful systems among the OxPt drug delivery procedures.
Several clinical trials have been carried out to investigate the side effects and dose-limiting
toxicity of liposomal oxaliplatin, such as the assessment on Safety Study of MBP-426 (Liposomal
Oxaliplatin Suspension for Injection) to Treat Advanced or Metastatic Solid Tumors. In addition,
several studies indicated the biocompatibility and biodegradability of this product, as well as
its option for being fictionalized to derive specialized smart nanosystems for the treatment of cancer.
The better delivery of OxPt with weaker side effects could be generated by the exertion of Oxaliplatin,
which involves the aggregation of new particles and multifaceted nanocarriers to compose
a nanocomposite with both inorganic and organic nanoparticles.
Neochamaejasmine A Promotes Apoptosis and Cell Cycle Arrest in
B16F10 Melanoma Cells via JNK and p38 MAPK Signaling Pathway
Authors: Chen Xiaoyu , Zhao Wei , Zhu Weiwei , Yu Lan , Zhu Xuejie , Ding Yangfang , Zheng Qiusheng 
Published: January 2022

Background:
The incidence of melanoma has been increasing over the last 30 years.
The most common treatments, such as surgery, chemotherapy, and radiotherapy, frequently cause
serious damage to the body. It is therefore critical to develop a new therapeutic strategy for the
treatment of melanoma.

Objectives:
This research aims to evaluate the anti-tumor effect of Neochamaejasmine A (NCA) on
B16F10 melanoma cells and the underlying molecular mechanisms.

Methods:
The CCK-8 kit was utilized to assay the influence of NCA on the vitality of B16F10
cells. Modifications in B16F10 cells morphology were observed using a phase-contrast microscope.
Apoptosis of B16F10 melanoma cells was assessed by Hoechst 33258, Annexin V and propidium
iodide staining. Cell cycle was detected using a commercial kit by flow cytometry. The mRNA
and protein expression levels associated with apoptosis and cell cycle arrest were detected by
RT-PCR and Western blot. The expression level of pathway proteins was assessed using Western
blot.

Result:
It was found that the proliferation of B16F10 cells was inhibited by NCA in concentration-
and time-dependent manners. NCA promoted apoptosis by halting the cell cycle at the G2/M
phase. After treatment with NCA, cell apoptosis was confirmed by Hoechst 33258 staining. NCA
triggered the cell cycle to seize at the G2/M stage by downregulating cyclin B1 and cyclin-dependent
kinase 2 (CDC2) expression. Moreover, the mRNA and protein expression of cleaved caspase-
9 and Bcl-2-associated X-protein (Bax) were increased, whereas there was a decline in the expression
of B-cell lymphoma 2 (Bcl-2). The p-p38/p38 and phosphorylated c-Jun N-terminal kinase
(p-JNK/JNK) ratio were also elevated by NCA. The apoptosis and G2/M cell cycle arrest
were inhibited in cells co-treated with the p38 inhibitor SB203580 and JNK inhibitor SP600125.
The expression of apoptosis-related proteins Bax was decreased, and Bcl-2 was increased.

Conclusion:
The findings of this study showed that NCA could induce apoptosis and cell cycle arrest
in B16F10 melanoma cells by activating JNK and p38 MAPK signaling pathway.
Cenobamate: A Review of its Pharmacological Properties, Clinical Efficacy
and Tolerability Profile in the Treatment of Epilepsy
Authors: Barbieri Maria Antonietta , Perucca Emilio , Spina Edoardo , Rota Paola , Franco Valentina 
Published: January 2022

Abstract:
Cenobamate is a novel antiseizure medication (ASM) commercially available in Europe
and in the U.S. for the treatment of focal seizures in adults. The mechanisms responsible for its antiseizure
activity include enhancement of the inactivated state of voltage-gated sodium channels with
blockade of the persistent sodium current and positive allosteric modulation of GABAA receptors at
a non-benzodiazepine binding site. Cenobamate has a high oral bioavailability that is not influenced
by food intake. The terminal half-life is 50-60 hours, allowing for once-daily dosing. Cenobamate
is a CYP2C19 inhibitor and an inducer of CYP3A4 and CYP2B6, and consequently, it can
cause a number of drug-drug interactions. Efficacy and safety have been evaluated in two randomized,
double-blind, placebo-controlled adjunctive therapy trials in adults with focal seizures. In
both trials, cenobamate decreased significantly the frequency of focal seizures, with relatively high
seizure freedom rates. Adverse events most commonly reported in double-blind trials included
dizziness, somnolence, headache, fatigue, and diplopia. The occurrence of three cases of drug reaction
with eosinophilia and systemic symptoms (DRESS) during early clinical development led to
the conduction of a Phase 3 open-label long-term safety study in a total of 1339 patients. In this
study, no serious idiosyncratic adverse reactions were observed using a start-low and go-slow approach.
Further studies are required to determine whether the clinical activity profile of cenobamate
extends to protection against other seizure types and to evaluate its efficacy and safety profile
in special patient groups such as infants, children, the elderly, and patients with comorbid conditions.
A Quantitative Estimation of the Behaviour of Unsaturated Lipid Molecular
Species During Their Argentation Liquid Chromatographic Separation
Authors: Pchelkin Vasiliy P. 
Published: January 2022

Background:
Analysis of experimental retention data upon several variants of argentation
liquid chromatographic separations of different mixtures of the same lipid class into their
molecular species was made to estimate new parameters of their π-complexes for every unsaturated
fatty acid residue as its silver ion cluster.

Methods:
Planar reversed-phase liquid chromatography, both in the presence and absence of silver
ions as well as adsorption argentation liquid chromatography was applied for the separation of complex
rac-1,2-diacylglycerol samples from three plant sources (cocoa butter, poppy seed, and
linseed oils).

Results:
Every value of the argentation liquid chromatographic separation selectivity for any lipid
molecular species upon both planar and column variants of reversed-phase fractionation of different
complex samples from native sources into their molecular components is described by additive
relative polarity levels of their fatty acid residues. These levels are always connected with equivalent
lipophilicity values for every lipid molecule and its potential chemical variations during all
variants of reversed-phase liquid chromatography in the presence of silver ion clusters.

Conclusion:
New parameters for several fatty acid residues of major native polyunsaturated lipid
samples may be reflected by different coordination numbers of single silver atoms of its triangular
pyramidal nanoclusters. Both hydrophobicity and total polarity levels of the coordination complexes
of different lipid molecular species upon their adsorption argentation liquid chromatography
may also be quantitatively estimated by their fixed methylene unit variations of these molecular
species for two centigrade lipid scales.
A Mobile App for Advance Care Planning and Advance Directives (Accordons-nous): Development and Usability Study
Authors: Schöpfer Céline , Ehrler Frederic , Berger Antoine , Bollondi Pauly Catherine , Buytaert Laurence , De La Serna Camille , Hartheiser Florence , Fassier Thomas , Clavien Christine 
Published: January 2022

Background
Advance care planning, including advance directives, is an important tool that allows patients to express their preferences for care if they are no longer able to express themselves. We developed Accordons-nous, a smartphone app that informs patients about advance care planning and advance directives, facilitates communication on these sensitive topics, and helps patients express their values and preferences for care.

Objective
The first objective of this study is to conduct a usability test of this app. The second objective is to collect users’ critical opinions on the usability and relevance of the tool.

Methods
We conducted a usability test by means of a think-aloud method, asking 10 representative patients to complete 7 browsing tasks. We double coded the filmed sessions to obtain descriptive data on task completion (with or without help), time spent, number of clicks, and the types of problems encountered. We assessed the severity of the problems encountered and identified the modifications needed to address these problems. We evaluated the readability of the app using Scolarius, a French equivalent of the Flesch Reading Ease test. By means of a posttest questionnaire, we asked participants to assess the app’s usability (System Usability Scale), relevance (Mobile App Rating Scale, section F), and whether they would recommend the app to the target groups: patients, health professionals, and patients’ caring relatives.

Results
Participants completed the 7 think-aloud tasks in 80% (56/70) of the cases without any help from the experimenter, in 16% (11/70) of the cases with some help, and failed in 4% (3/70) of the cases. The analysis of failures and difficulties encountered revealed a series of major usability problems that could be addressed with minor modifications to the app. Accordons-nous obtained high scores on readability (overall score of 87.4 on Scolarius test, corresponding to elementary school level), usability (85.3/100 on System Usability Scale test), relevance (4.3/5 on the Mobile App Rating Scale, section F), and overall subjective endorsement on 3 I would recommend questions (4.7/5).

Conclusions
This usability test helped us make the final changes to our app before its official launch.
Rendimiento de un Sistema Solar Fotovoltaico Mixto (Policristalinos y Amorfo) Usado como Suministro Energético en un Contexto de Tecnificación Cafetera
Authors: Idrobo-Pacheco Hermes Leonardo , Murillo-Arango Walter , Lara-Galvis Juan David , Chávez-Ruiz Daniel Fernando 
Published: January 2022

Introducción. El aprovechamiento de fuentes renovables de energía, y en especial la fotovoltaica, se ha convertido en una herramienta clave en el campo de la producción más limpia, ayudando a promover el desarrollo sostenible en muchos sectores, entre ellos el agrícola, convirtiéndose en una oportunidad de impulso para el sector. Objetivo. Este estudio evaluó el rendimiento de una instalación de paneles fotovoltaicos con dos tecnologías diferentes a través del diseño y construcción de un dispositivo electrónico de adquisición de datos comparador de curvas de potencia. Materiales y Métodos. Se consideraron dos tipos de tecnologías de paneles, (policristalinos y los amorfos) como suministro de energía eléctrica en el proceso de beneficio de café del Parque Tecnológico del Café – TECNICAFÉ- SUPRACAFÉ, Cauca, Colombia. Se diseñó un prototipo hardware con software libre, en una placa Arduino con un microcontrolador capaz de medir la irradiancia, potencia, y respuesta térmica de cada panel solar, y se calculó la energía generada con los tipos de instalaciones (paralelo y serie) Los datos de voltaje, corriente eléctrica y temperatura se almacenaron en el módulo micro SD de la tarjeta para luego graficarlas como curvas características entrega de potencia. Los Resultados sugieren la existencia de una relación directa entre la potencia entregada por los paneles con la variable de irradiancia. Los paneles policristalinos entregaron mayor potencia que los amorfos, reportando una eficiencia práctica de 11 % y 4.8 % respectivamente. Conclusión. El diseño logrado en esta investigación representa una oportunidad para mejorar el desempeño energético del sector cafetero.
Análisis del Papel de los Intermediarios en el Mercado Agrícola Tradicional
Authors: Acosta-Agudelo Melissa María , Giraldo Diana P. , Vélez-Acosta Lina María , Fernández-Ledesma Javier 
Published: January 2022

Introducción. En este trabajo se analiza la participación de los intermediarios en el mercado agrícola tradicional de frutas y hortalizas en fresco en el departamento de Antioquia, Colombia; sus resultados sirven de apoyo para explicar las relaciones entre intermediarios con productores, consumidores y otros intermediarios. El objetivo es analizar el papel de los intermediarios y su poder de negociación; a fin de explorar las diferentes interacciones, condiciones del sistema y las ventajas y desventajas, se analiza las similitudes que presentan algunos intermediarios de plazas de mercado. Materiales y métodos: para ello se realizó entrevistas y un cuestionario estructurado a 26 intermediarios ubicados en 13 municipios de las 9 subregiones de Antioquia, adicionalmente se realizaron algunos cuestionarios a intermediarios de tiendas de barrio, consumidores y productores para contrastar diferentes puntos de vista; a la información obtenida se le realizó análisis de conglomerados, análisis multivariado, comparación de varias muestras y análisis de componentes principales, los Resultados arrojaron que los intermediarios eliminan fronteras de negociación definiendo criterios de comercio, tienen gran participación tanto en procedencia como en oferta y presentan similitudes entre una zona y otra que no precisamente corresponden a proximidades geográficas. Conclusión: En suma, frente a la alta participación de estos agentes en las cadenas de suministro de alimentos, son ellos quienes aprovechan las fallas y dinámicas del sistema para definir reglas de negociación cuando están en su rol de vendedores a otros intermediarios o cuando están en el rol de compradores a productores.
Perancangan Bioskop Wayang Lakon Jabang Tetuka (The Design of Shadow Puppet Movie Theater of Jabang Tetuka Play)
Authors: Kiswantoro Aneng 
Published: January 2022

AbstractThe Design of Shadow Puppet Movie Theater of Jabang Tetuka Play. This paper aimed to discuss the design of Puppet Cinema with the Jabang Tetuka play. It was assumed that by utilizing digital and audio-visual technology, puppet shows are able to compete with other performances. Puppet Cinema Pakeliran with the Jabang Tetuka play was designed based on the concept of presenting a cinema film. This concept prioritizes two things, namely audio and visual. Jabang Tetuka play was taken from the Javanese shadow puppet story. Alma M. Hawkins design method used as the design method of this work. The Hawkins method includes three stages in the design, namely exploration, experimentation, and formation. The result obtained is a puppet show (pakeliran) of puppet cinema with the Jabang Tetuka play. AbstrakTulisan ini membahas perancangan Bioskop Wayang dengan lakon Jabang Tetuka. Diasumsikan dengan memanfaatkan teknologi digital dan audio-visual, pertunjukan wayang mampu bersaing dengan pertunjukan yang lain. Pakeliran Bioskop Wayang dengan lakon Jabang Tetuka dirancang berdasarkan konsep penyajian film bioskop. Konsep ini mengutamakan dua hal yaitu audio dan visual. Lakon Jabang Tetuka diambil dari cerita wayang kulit purwa. Metode perancangan Alma M. Hawkins dipakai sebagai metode perancangan karya ini. Dalam metode Hawkins tercakup tiga tahapan dalam perancangan ialah eksplorasi, eksperimentasi, dan pembentukan. Hasil yang didapat ialah pertunjukan wayang (pakeliran) bioskop wayang dengan lakon Jabang Tetuka.
The Indonesian Ministry of Finance’s 2021 National Economic Recovery Program Strategy
Authors: Yuliana Yuliana 
Published: January 2022

The government has implemented the national economic recovery program in 2021. The Financial Ministry of Indonesia Republic has announced a press release based on the national economic recovery program. This program is essential because the COVID-19 pandemic has not been ended yet, although the vaccination program has been done. The economic recession still happens. This paper aims to describe the national economic recovery program in 2021. Methodology: a literature review. Literature was derived from Google Scholar and Science Direct. The result showed that the National Economic Recovery Program coordinates and synergy among the Government, Bank Indonesia, Finance Service Authority, Saving Guarantee Institution, and banks. The national economic recovery program protects the consumption and purchasing power of the poor and vulnerable, funding for small and medium enterprises, tax incentives for businesses, the establishment of labour-intensive projects to absorb labour, and credit restructuring.
Juliusz Cezar – tyran czy nadzieja Rzeczpospolitej? Analiza mowy Pro Marcello Marka Tulliusza Cycerona
Authors: Banach Tomasz 
Published: January 2022

Przedmiot badań: W artykule dokonano analizy mowy Pro Marcello Cycerona w ścisłym związ­ku z problemem politycznym, którego mowa dotyczyła. Komparatystyczne zestawienie mowy z poglądami zaprezentowanymi w dialogu De re publica dowodzi, że cycerońska retoryka odpo­wiada w tym wypadku wcześniej zaprezentowanej filozofii politycznej. Jednocześnie potwierdza także niezmienny antytyraniczny wymiar wystąpień Cycerona, dla którego wolność rzymskiej wspólnoty politycznej od tyranii i jej odmian jest wartością nadrzędną.
Cel badawczy: Analiza mowy Pro Marcello oraz wskazanie jej antytyranicznego wymiaru.
Metoda badawcza: W artykule wykorzystano metodę historyczno-prawną oraz metodę po­równawczą.
Wyniki: Mowa Pro Marcello jest w istocie republikańskim komunikatem kierowanym do zwy­cięskiego wodza, który w przekonaniu Cycerona, kierując się dobrem wspólnym – rei publicae causa, winien podążyć drogą prowadzącą do „najlepszego ustroju” (optimus status rei publicae). Cyceron w Pro Marcello stawia Cezara w miejscu, które przypisywał Scypionowi w De re publi­ca, jako politykowi (rector rei publicae), któremu „przyjdzie zostać dyktatorem i uporządkować sprawy rzeczpospolitej”.
Robo-doradztwo. Profesjonalna budowa i zarządzanie portfelem inwestycyjnym
Authors: Kujawa Sławomir 
Published: January 2022

Przedmiot badań: Przedmiotem badań jest usługa robo-doradztwa inwestycyjnego w kontekście jej idei, atrybutów, dostępności w wybranych krajach oraz roli w profesjonalnej budowie i za­rządzaniu portfelem inwestycyjnym. Przedmiotem badania ankietowego jest analiza znajomości usługi robo-doradztwa w Polsce i jej akceptacji wśród respondentów.
Cele badawcze: Cel 1: Charakterystyka robo-doradztwa. Cel 2: Rola robo-doradztwa w profesjo­nalnym budowaniu oraz zarządzaniu portfelem inwestycyjnym dla nieprofesjonalnych uczestni­ków rynku. Cel 3: Przegląd dostępnych usług robo-doradztwa inwestycyjnego w wybranych kra­jach europejskich i USA. Cel 4: Prezentacja wyników badań ankietowych nt. znajomości usługi robo-doradztwa inwestycyjnego w Polsce i jej akceptacji wśród respondentów.
Metoda badawcza: Metoda 1: Analiza porównawcza 18 usług robo-doradczych z wybranych kra­jów. Metoda 2: Badanie ankietowe, dotyczące usługi robo-doradztwa w Polsce, zrealizowane techniką CAWI. 1
Wyniki: Obszary wchodzące w zakres usługi robo-doradztwa to m.in. profilowanie, doradztwo, równoważenie oraz indeksowanie. Wszystkie wymienione obszary są równie istotne w budowie oraz zarządzaniu portfelem inwestycyjnym. Robo-doradztwo może zminimalizować lub nawet wyeliminować wiele ryzyk na etapie identyfikacji celów inwestora, podziału portfela na klasy aktywów, wyboru aktywów do portfela czy też monitorowaniu składu portfela. Wykonana analiza porównawcza potwierdziła szeroką dostępność usług robo-doradczych na rynku europejskim oraz USA. Analizowane platformy różnią się między sobą głównie na płaszczyźnie kosztów, minimal­nych poziomów wpłat czy też dostępności doradcy, która nie jest tak oczywista. Usługi robo-do­radcze posiadają również wspólne cechy, w postaci szerokiej dostępności funduszy typu ETF, które można wykorzystać do budowy portfeli inwestycyjnych. W Polsce oferta usług robo-do­radztwa inwestycyjnego jest bardzo wąska. Z badań wynika niewielka znajomość oraz doświad­czenie ankietowanych w obszarze usług robo-doradczych. Ankietowani mający doświadczenie z doradcą oraz robo-doradcą ocenili robo-doradcę lepiej o 0,62 pkt. (w skali 1–5) od doradcy. W badaniach respondenci dostrzegli zarówno zalety, jak i wady usługi robo-doradczej. Samą usługę należy traktować nie jako zagrożenie dla dotychczasowych doradców, ale ich uzupełnie­nie sprawiające, że model hybrydowy łączący fizycznego doradcę wspomaganego rozwiązaniami technologicznymi stanie się modelem najbardziej prawdopodobnym.