bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic Adenocarcinoma Associated with Vocal Cord Paralysis
Authors: Chelal Aref , ALakkad Ashraf , Melki Sami 
Published: July 2022

A 30-year-old male patient presented with a mixed complaint. He initially had developed complaints of backache two months ago. This pain was accompanied by the formation of two lumps in the back in the upper and lower regions. However, this was not the reason behind him presenting to the hospital. He complained of hoarseness of the voice, which seemed to have no background.
The man is neither an alcoholic nor a smoker. He has no significant medical or surgical history. His work history also remains unrelated to the hoarseness of his voice, as he is not required to speak loudly, which is typically linked to over exertion of the vocal cords.
Upon examination, it was learned that the two lumps that the patient had initially observed had grown in number. Now, there were several lumps on his back and shoulder regions.
When this particular observation, coupled with the hoarseness of voice, was investigated via diagnostic imaging techniques such as X-ray, CT, and MRI, it was discovered that the patient was suffering from Grade IV Pancreatic Adenocarcinoma. The cancer had progressed significantly as there was numerous organ involvement observed. The liver, adrenal glands, lungs, subcutaneous tissues, and muscles were all seen to be involved. Along with this, he had also developed bilateral deep vein thrombosis on both his lower limbs.
Although the patient had no significant symptoms that could have forced an earlier diagnosis, it was evident that the carcinoma was pancreato-biliary in origin.
The patient is now undergoing his chemotherapy, and so far, he has shown a remarkable ‘partial’ response to his treatment cycles. Therefore, a good prognosis is hoped if the progress remains the same over time.
This case study aims to reflect on all the possible angles of this patient’s presentation. It is also the utmost priority to correlate and investigate the link of his hoarseness with his actual cancer. This case study will guide future physicians and clinicians who will come across confusing cases such as these to reach a conclusive diagnosis.
Had it not been for the advanced diagnostic imaging technologies available within reach of both the hospital and the patient, the patient undoubtedly would have only been treated for his hoarseness, leaving the actual disease unchecked, undiagnosed, and untreated.
Surface Transformation Enables a Dendrite‐Free Zinc‐Metal Anode in Nonaqueous Electrolyte
Authors: Huang Fanyang , Li Xinpeng , Zhang Yuchen , Jie Yulin , Mu Xulin , Yang Chaoran , Li Wanxia , Chen Yawei , Liu Yang , Wang Shuai , Ge Binghui , Cao Ruiguo , Ren Xiaodi , Yan Pengfei , Li Qi , Xu Dongsheng , Jiao Shuhong 
Published: July 2022

AbstractSignificant challenges remain in developing rechargeable zinc batteries mainly because of reversibility problems on zinc‐metal anodes. The dendritic growth and hydrogen evolution on zinc electrodes are major obstacles to overcome in developing practical and safe zinc batteries. Here, a dendrite‐free and hydrogen‐free Zn‐metal anode with high Coulombic efficiency up to 99.6% over 300 cycles is realized in a newly designed nonaqueous electrolyte, which comprises an inexpensive zinc salt, zinc acetate, and a green low‐cost solvent, dimethyl sulfoxide. Surface transformation on Cu substrate plays a critical role in facilitating the dendrite‐free deposition process, which lowers the diffusion energy barrier of the Zn atoms, leading to a uniform and compact thin film for zinc plating. Furthermore, in situ electrochemical atomic force microscopy reveals the plating process via a layer‐by‐layer growth mechanism and the stripping process through an edge‐dissolution mechanism. In addition, Zn||Mo6S8 full cells exhibit excellent electrochemical performance in terms of cycling stability and rate capability. This work presents a new opportunity to develop nonaqueous rechargeable zinc batteries.
Recent Advances for Alkylation of Ketones and Secondary Alcohols Using Alcohols in Homogeneous Catalysis
Authors: Yang Dong‐Yuan , Wang Hongli , Chang Chun‐Ran 
Published: July 2022

AbstractThe alkylation of ketones or secondary alcohols using alcohols as alkylating agents via hydrogen borrowing strategy presents a powerful method for the synthesis of ɑ‐alkylated ketones. In this review, we summarize the progress catalyzed by Ir, Pd, Rh, Ru, Mn, Fe, Co, Ni, and Cu catalysts for the α‐alkylation of ketones with alcohols and cross‐coupling of secondary alcohols with alcohols from 2017 to 2021. A wide range of ketones (aromatic and aliphatic ketones) and alcohols (benzylic and aliphatic primary alcohols, aromatic and aliphatic secondary alcohols, alkenyl alcohols, and diols) are well tolerated. Furthermore, we also discuss current challenges and propose perspectives on the coming development in this filed. The objective of the present review is to give an overview on recent advances for α‐alkylation of ketones with alcohols and β‐alkylation of secondary alcohols with alcohols. Finally, we hope that this review will give inspirations on alkylation of ketones or secondary alcohols with alcohols.magnified image
Hepatic histologic findings in a case of MEGDHEL syndrome due to SERAC1 deficiency
Authors: Yuen Lisa , Sahai Inderneel , O'Grady Lauren , Selig Martin , Walker Melissa Anne , Shah Uzma , Misdraji Joseph 
Published: July 2022

AbstractMEGD(H)EL syndrome is a rare autosomal recessive disorder caused by mutations in SERAC1, a protein necessary for phosphatidylglycerol remodeling. It is characterized by 3‐methylglutaconic aciduria, deafness‐dystonia, (hepatopathy), encephalopathy, and Leigh‐like syndrome, but has a wide spectrum of severity. Here, we present a case of a child with MEGD(H)EL syndrome with infantile hepatopathy, neurodevelopmental delays, characteristic biochemical abnormalities, and biallelic novel SERAC1 mutations: (1) deletion of (at least) exons 2–4, pathogenic; and (2) c.1601A>T (p.H534L), likely pathogenic. Her initial clinical presentation was notable for persistently elevated transaminases, speech delay, delayed motor milestones, and sensorineural hearing loss. However, her verbal and motor development has progressively improved and now, at 4 years of age, she has only speech and mild gross motor delays as compared to her unaffected peers and is exceeding clinical expectations. The histologic features of a liver biopsy are described, which has not previously been published in detail for this syndrome. Hepatocytes showed granular cytoplasm and fine intracytoplasmic lipid droplets. The ultrastructural findings included abnormal circular mitochondrial cristae. These findings are consistent with a mitochondrial disorder.
Recommendations to encourage participation of individuals from diverse backgrounds in psychiatric genetic studies
Authors: MacDermod Casey , Pettie Michaela A. , Carrino Emily A. , Garcia Susana Cruz , Padalecki Sophie , Finch Jody E. , Sanzari Christina , Kennedy Hannah L. , Pawar Pratiksha S. , Mcgough Makenna M. , Iwashita Ava , Takgbajouah Mary , Coan Danielle , Szakasits Lindsey , Goode Rachel W. , Wu Ya‐Ke , Reyes‐Rodríguez Mae Lynn , Vacuán Eva María Trujillo Chi , Kennedy Martin A. , Cleland Lana , Jordan Jennifer , Maguire Sarah , Guintivano Jerry D. , Giusti‐Rodríguez Paola , Baker Jessica H. , Thornton Laura M. , Bulik Cynthia M. 
Published: July 2022

AbstractWe present innovative research practices in psychiatric genetic studies to ensure representation of individuals from diverse ancestry, sex assigned at birth, gender identity, age, body shape and size, and socioeconomic backgrounds. Due to histories of inappropriate and harmful practices against marginalized groups in both psychiatry and genetics, people of certain identities may be hesitant to participate in research studies. Yet their participation is essential to ensure diverse representation, as it is incorrect to assume that the same genetic and environmental factors influence the risk for various psychiatric disorders across all demographic groups. We present approaches developed as part of the Eating Disorders Genetics Initiative (EDGI), a study that required tailored approaches to recruit diverse populations across many countries. Considerations include research priorities and design, recruitment and study branding, transparency, and community investment and ownership. Ensuring representation in participants is costly and funders need to provide adequate support to achieve diversity in recruitment in prime awards, not just as supplemental afterthoughts. The need for diverse samples in genetic studies is critical to minimize the risk of perpetuating health disparities in psychiatry and other health research. Although the EDGI strategies were designed specifically to attract and enroll individuals with eating disorders, our approach is broadly applicable across psychiatry and other fields.
Stabile zweibeinige Klavierstuhl‐Carbonyl‐ und gemischte Diborabenzol‐E4 (E=P, As) Sandwichkomplexe der Gruppe 8
Authors: Dietz Maximilian , Arrowsmith Merle , Reichl Stephan , Lugo‐Fuentes Leonardo I. , Jiménez‐Halla J. Oscar C. , Scheer Manfred , Braunschweig Holger 
Published: July 2022

AbstractEin cyclisches Alkyl(amino)carben‐stabilisierter 1,4‐Diborabenzol‐Ligand (DBB) ermöglichte die Isolierung von zweibeinigen 18‐Elektronen Klavierstuhl‐Komplexen von Fe0 und Ru0 der Form [(η6‐DBB)M(CO)2], wobei der Rutheniumkomplex der erste seiner Art ist, der strukturell charakterisiert wurde. [(η6‐DBB)Fe(CO)2] reagierte mit E4 (E=P, As) unter Ausbildung von gemischten DBB‐cyclo‐E4‐Sandwichkomplexen mit planaren E42− Liganden. Quantenchemische Berechnungen bestätigen die hohe Elektrondonorstärke des DBB Liganden und zeigen, dass die E4‐Liganden über vier äquivalente Fe‐P‐σ‐Bindungen gebunden sind.
Borane/Gold(I)‐Catalyzed C−H Functionalization Reactions and Cycloaddition Reactions of Amines and α‐Alkynylenones
Authors: Tian Jun‐Jie , Sun Wei , Li Rui‐Rui , Tian Gui‐Xiu , Wang Xiao‐Chen 
Published: July 2022

AbstractWe designed a borane/gold(I) co‐catalytic system and used it for C−H functionalization reactions and cycloaddition reactions between tertiary amines and α‐alkynylenones. Both reactions effectively incorporated a furan ring into the amine.
Double‐Cable Conjugated Polymers with Pendent Near‐Infrared Electron Acceptors for Single‐Component Organic Solar Cells
Authors: Liang Shijie , Liu Baiqiao , Karuthedath Safakath , Wang Jing , He Yakun , Tan Wen Liang , Li Hao , Xu Yunhua , Li Ning , Hou Jianhui , Tang Zheng , Laquai Frédéric , McNeill Christopher R. , Brabec Christoph J. , Li Weiwei 
Published: July 2022

AbstractDouble‐cable conjugated polymers with near‐infrared (NIR) electron acceptors are synthesized for use in single‐component organic solar cells (SCOSCs). Through the development of a judicious synthetic pathway, the highly sensitive nature of the 2‐(3‐oxo‐2,3‐dihydroinden‐1‐ylidene)malononitrile (IC)‐based electron acceptors in basic and protonic solvents is overcome. In addition, an asymmetric design motif is adopted to optimize the packing of donor and acceptor segments, enhancing charge separation efficiency. As such, the new double‐cable polymers are successfully applied in SCOSCs, providing an efficiency of over 10 % with a broad photo response from 300 to 850 nm and exhibiting excellent thermal/light stability. These results demonstrate the powerful design of NIR‐acceptor‐based double‐cable polymers and will enable SCOSCs to enter a new stage.
Small‐Molecular‐Weight Additives Modulate Calcification by Interacting with Prenucleation Clusters on the Molecular Level**
Authors: Duchstein Patrick , Schodder Philipp I. , Leupold Simon , Dao Thi Q. N. , Kababya Shifi , Cicconi Maria R. , de Ligny Dominique , Pipich Vitaliy , Eike David , Schmidt Asher , Zahn Dirk , Wolf Stephan E. 
Published: July 2022

AbstractSmall‐molecular‐weight (MW) additives can strongly impact amorphous calcium carbonate (ACC), playing an elusive role in biogenic, geologic, and industrial calcification. Here, we present molecular mechanisms by which these additives regulate stability and composition of both CaCO3 solutions and solid ACC. Potent antiscalants inhibit ACC precipitation by interacting with prenucleation clusters (PNCs); they specifically trigger and integrate into PNCs or feed PNC growth actively. Only PNC‐interacting additives are traceable in ACC, considerably stabilizing it against crystallization. The selective incorporation of potent additives in PNCs is a reliable chemical label that provides conclusive chemical evidence that ACC is a molecular PNC‐derived precipitate. Our results reveal additive‐cluster interactions beyond established mechanistic conceptions. They reassess the role of small‐MW molecules in crystallization and biomineralization while breaking grounds for new sustainable antiscalants.
Lastfall Impakt – Modellierung hochdynamischer Antworten von Strukturen aus bewehrtem Beton
Authors: Storm Johannes , Chihadeh Ahmad , Graf Wolfgang , Kaliske Michael 
Published: July 2022

AbstractDie Berechnung dynamischer Versagensprozesse in Tragstrukturen ist eine ingenieurtechnische Herausforderung und Triebkraft der methodischen Entwicklung. Im Beitrag werden numerische Modelle für spröden Materialbruch und die partielle Ablösung der Bewehrung bei impulsartiger Bauteilbeanspruchung behandelt. Für das Versagen in Grenzschichten werden Methoden zur Reduktion des Rechenaufwands gezeigt. Grundlegend neue Ansätze sind aus der Forschung zur Rissberechnung hervorgegangen und werden mit einigen Beispielen vorgestellt. Der vorliegende Beitrag wurde am 15. Okt. 2021 im Rahmen des 25. Dresdner Baustatik‐Seminars präsentiert.
Association between mutational subgroups, Warburg‐subtypes, and survival in patients with colorectal cancer
Authors: Offermans Kelly , Jenniskens Josien C. A. , Simons Colinda C. J. M. , Samarska Iryna , Fazzi Gregorio E. , van der Meer Jaleesa R. M. , Smits Kim M. , Schouten Leo J. , Weijenberg Matty P. , Grabsch Heike I. , van den Brandt Piet A. 
Published: July 2022

AbstractBackgroundPrevious research suggests that Warburg‐subtypes are related to potentially important survival differences in colorectal cancer (CRC) patients. In the present study, we investigated whether mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, and MET, which are known to promote the Warburg‐effect, as well as mismatch repair (MMR) status, hold prognostic value in CRC. In addition, we investigated whether Warburg‐subtypes provide additional prognostic information, independent of known prognostic factors like TNM stage.MethodsCRC patients (n = 2344) from the prospective Netherlands Cohort Study (NLCS) were classified into eight mutually exclusive mutational subgroups, based on observed mutations in RAS, BRAF, PIK3CA, and MET, and MMR status: All‐wild‐type + MMRproficient, KRASmut + MMRproficient, KRASmut + PIK3CAmut + MMRproficient, PIK3CAmut + MMRproficient, BRAFmut + MMRproficient, BRAFmut + MMRdeficient, other + MMRproficient, and other + MMRdeficient. Kaplan–Meier curves and Cox regression models were used to investigate associations between mutational subgroups and survival, as well as associations between our previously established Warburg‐subtypes and survival within these mutational subgroups.ResultsCompared to patients with all‐wild‐type + MMRproficient CRC, patients with KRASmut + MMRproficient, KRASmut + PIK3CAmut + MMRproficient, BRAFmut + MMRproficient, or other + MMRproficient CRC had a statistically significant worse survival (HRCRC‐specific ranged from 1.29 to 1.88). In contrast, patients with other + MMRdeficient CRC had the most favorable survival (HRCRC‐specific 0.48). No statistically significant survival differences were observed for the Warburg‐subtypes within mutational subgroups.ConclusionOur results highlight the prognostic potential of mutational subgroups in CRC. Warburg‐subtypes did not provide additional prognostic information within these mutational subgroups. Future larger‐scale prospective studies are necessary to validate our findings and to examine the potential clinical utility of CRC subtyping based on mutational subgroups.
Trust me if you can: The effect of driver username on passengers' intention to use ride‐sharing service
Authors: Fu Huijian , He Junhong , Hong Jianhong , Hu Linfeng 
Published: July 2022

AbstractBuilding trust and enhancing consumers' participation are critical for the growth of peer‐to‐peer sharing economy. This research explores the effect of driver username on passengers' intention to use ride‐sharing service and its underlying psychological mechanisms. The results indicate that driver username has a significant impact on passengers' intention to use ride‐sharing service, as a driver with a real name elicits greater intention to use ride‐sharing service than a driver with a screen name (studies 1, 2, 3a, 3b, and 3c). In addition, the effect of driver username on passengers' intention to use ride‐sharing service is serially mediated by social presence and trust (study 2). Importantly, the effect of driver username on passengers' intention to use ride‐sharing service is moderated by driver reputation (studies 3a, 3b, and 3c). A high (vs. low) reputation facilitates the impact of driver username on passengers' usage intention. Based upon these findings, theoretical and practical implications are discussed.
A High‐Throughput Continuous Spectroscopic Assay to Measure the Activity of Natural Product Methyltransferases
Authors: Simon‐Baram Hadas , Roth Steffen , Niedermayer Christina , Huber Patricia , Speck Melanie , Diener Julia , Richter Michael , Bershtein Shimon 
Published: July 2022

AbstractNatural product methyltransferases (NPMTs) represent an emerging class of enzymes that can be of great use for the structural and functional diversification of bioactive compounds, such as the strategic modification of C‐, N‐, O‐ and S‐moieties. To assess the activity and the substrate scope of the ever‐expanding repertoire of NPMTs, a simple, fast, and robust assay is needed. Here, we report a continuous spectroscopic assay, in which S‐adenosyl‐L‐methionine‐dependent methylation is linked to NADH oxidation through the coupled activities of S‐adenosyl‐L‐homocysteine (SAH) deaminase and glutamate dehydrogenase. The assay is highly suitable for a high‐throughput evaluation of small molecule methylation and for determining the catalytic parameters of NPMTs under conditions that remove the potent inhibition by SAH. Through the modular design, the assay can be extended to match the needs of different aspects of methyltransferase cascade reactions and respective applications.
Dissecting Noncovalent Interactions in Carboxyl‐Functionalized Ionic Liquids Exhibiting Double and Single Hydrogens Bonds Between Ions of Like Charge
Authors: Hunger Lasse , Al‐Sheakh Loai , Zaitsau Dzmitry H. , Verevkin Sergey P. , Appelhagen Andreas , Villinger Alexander , Ludwig Ralf 
Published: July 2022

AbstractWe show that the carboxyl‐functionalized ionic liquid 1‐(carboxymethyl)pyridinium bis(trifluoromethylsulfonyl)imide [HOOC‐CH2‐py][NTf2] exhibits three types of hydrogen bonding: the expected single hydrogen bonds between cation and anion, and, surprisingly, single and double hydrogen bonds between the cations, despite the repulsive Coulomb forces between the ions of like charge. Combining X‐ray crystallography, differential scanning calorimetry, IR spectroscopy, thermodynamic methods and DFT calculations allows the analysis and characterization of all types of hydrogen bonding present in the solid, liquid and gaseous states of the ionic liquid (IL). We find doubly hydrogen bonded cationic dimers (c+=c+) in the crystalline phase. With increasing temperature, this binding motif opens in the liquid and is replaced by (c+−c+−a− species, with a remaining single cationic hydrogen bond and an additional hydrogen bond between cation and anion. We provide clear evidence that the IL evaporates as hydrogen‐bonded ion pairs (c+−a−) into the gas phase. The measured transition enthalpies allow the noncovalent interactions to be dissected and the hydrogen bond strength between ions of like charge to be determined.
Pharmacokinetics of Icosapent Ethyl: An Open‐Label, Multiple Oral Dose, Parallel Design Study in Healthy Chinese Subjects
Authors: Yuan Fei , Li Hui , Yang Mengjie , Chen Weili , Chen Hanjing , Xu Hongrong , Li Jing , Sheng Lei , Liu Chao , Li Ye , Li Huan , Li Xuening 
Published: July 2022

AbstractIcosapent ethyl (IPE) is a high‐purity prescription form of eicosapentaenoic acid (EPA) ethyl ester that has been approved to lower triglyceride levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. Before this study, there were no pharmacokinetics (PK) or safety data in Chinese patients after receiving IPE. The purpose of this study was to evaluate the PK of EPA in plasma and red blood cells and safety after oral administration of IPE capsules for 28 consecutive days in healthy Chinese subjects. It was a randomized, open‐label, parallel‐designed multiple‐dose, phase I study. Twenty‐four subjects were enrolled and randomly assigned to 2 groups, including 6 men and 6 women in each group. Group A received IPE 2.0 g/day (1×1 g twice daily), and group B received IPE 4.0 g/day (2×1 g twice daily) with dosing after standard meals for 28 days. During the treatment period, PK samples were collected from all subjects before the morning dose on days 1, 14, 26, and 28. Following completion of the last study drug administration in the morning on day 28, an 18‐day posttreatment PK sample collection period was followed. Twenty‐four eligible subjects were enrolled in this study, and 1 subject withdrew from the study. The main PK parameters (baseline‐corrected maximum observed plasma concentration and area under the plasma concentration–time curve during a dosing interval) of plasma total EPA, RBC EPA, and plasma unesterified EPA increased with dose. Chinese healthy subjects who took IPE capsules orally in the dose range of 2.0 to 4.0 g/day for 28 consecutive days were safe and tolerable.
Photodynamic Antitumor Activity of 5,15‐Bis(perfluorophenyl)‐10‐(4‐carboxyphenyl)corrole and its Gallium(III) and Phosphorus(V) Complexes
Authors: Cen Jing‐He , Wan Bei , Zhao Yue , Li Meng‐Yuan , Liao Yu‐Hui , Liu Hai‐Yang 
Published: July 2022

AbstractThis work reports the preparation and characterization of an A2B corrole 5,15‐bis(perfluorophenyl)‐10‐(4‐carboxyphenyl)corrole and its gallium(III) and phosphorus(V) complexes. Their in‐vitro photodynamic anticancer activities against A549, MDA‐MB‐231, B16, HepG2, and Hela cell lines were also investigated. Among three compounds, phosphorus(V) complexexhibits the best photostability, highest fluorescence quantum yields (ΦF=0.138), and the highest singlet‐oxygen quantum yields (ΦΔ=0.87). Also, the phosphorus(V) complex exhibits the best photodynamic antitumor activity against MDA‐MB‐231 cells with a low IC50 (0.08 μM) upon light irradiation at 625±2 nm, which is much lower than commercial PDT drug Temoporfin (0.1 μM) at the same conditions. The cellular localization assay confirmed that the phosphorus(V) complexis mainly distributed in the cytoplasm and have a good ability to produce reactive oxygen species (ROS) under light illumination, which would further cause oxidative damage to tumor cells and finally result in the apoptosis. After PDT treatment, phosphorus(V) complex may cause tumor cell arrest at the G2/M stage. The preliminary results showed phosphorus(V) corrole complex is a good candidate for photodynamic therapy (PDT) of tumors.