bluuebunny/crossref_metadata_2025_split huggingface dataset:
COLETIVOS CULTURAIS CINECLUBISTAS DA BAIXADA FLUMINENSE: um conjunto de panoramas
Authors: Moreira Leonardo Cesar Alves , D’Arrochella Marcio Luiz Gonçalves , Cupolillo Pedro De Almeida 
Published: May 2022

O presente ensaio tem como objetivo realizar um estudo sobre dois Coletivos Culturais Cineclubistas da Baixada Fluminense, o Mate com Angu e Buraco do Getúlio, traçando um conjunto de panoramas sobre suas potencialidades educativas e de ocupação do espaço urbano através das relações entre os seus participantes, sujeitos periféricos (D’ANDREA, 2013), situados nos grupos que pluralizam e diversificam as juventudes contemporâneas (FEIXA, 2004; MARTÍN-BARBERO, 1997; DAYRELL, 2007). A partir deste estudo, são discutidos os conceitos de coletivo cultural e de cineclube, à luz da bibliografia disponível na plataforma de periódicos da CAPES e de pesquisa em documentos históricos, como revistas e estatutos que apresentam definições da prática cineclubista. Procurando refletir sobre a dualidade entre centro e periferia, a partir da Baixada Fluminense, contexto onde esses Coletivos se mobilizam, discutimos sobre o direito à cultura na cidade e a forma de atuação dos coletivos culturais através de entrevistas realizadas com integrantes dos Coletivos Culturais Cineclubistas. Por fim, apresentamos um conjunto de panoramas, refletindo sobre temas como a cotidianidade, as cidades, as culturas em sua estrita relação à juventude contemporânea, mais especificamente dos sujeitos periféricos.
What is the adult experience of Perthes’ disease?
Authors: McGuire Molly F. , Vakulenko-Lagun Bella , Millis Michael B. , Almakias Roi , Cole Earl P. , Kim Harry K. W. ,   A study from the International Perthes Study Group
Published: May 2022

Aims Perthes’ disease is an uncommon hip disorder with limited data on the long-term outcomes in adulthood. We partnered with community-based foundations and utilized web-based survey methodology to develop the Adult Perthes Survey, which includes demographics, childhood and adult Perthes’ disease history, the University of California Los Angeles (UCLA) Activity Scale item, Short Form-36, the Hip disability and Osteoarthritis Outcome Score, and a body pain diagram. Here we investigate the following questions: 1) what is the feasibility of obtaining > 1,000 survey responses from adults who had Perthes’ disease using a web-based platform?; and 2) what are the baseline characteristics and demographic composition of our sample? Methods The survey link was available publicly for 15 months and advertised among support groups. Of 1,505 participants who attempted the Adult Perthes survey, 1,182 completed it with a median timeframe of 11 minutes (IQR 8.633 to 14.72). Participants who dropped out were similar to those who completed the survey on several fixed variables. Participants represented 45 countries including the USA (n = 570; 48%), UK (n = 295; 25%), Australia (n = 133; 11%), and Canada (n = 46; 4%). Of the 1,182 respondents, 58% were female and the mean age was 39 years (SD 12.6). Results Ages at onset of Perthes’ disease were < six years (n = 512; 43%), six to seven years (n = 321; 27%), eight to 11 years (n = 261; 22%), and > 11 years (n = 76; 6%), similar to the known age distribution of Perthes’ disease. During childhood, 40% (n = 476) of respondents had at least one surgery. Bracing, weightbearing restriction, and absence of any treatment varied significantly between USA and non-USA respondents (p < 0.001, p = 0.002, and p < 0.001, respectively). As adults, 22% (n = 261) had at least one total hip arthroplasty, and 30% (n = 347) had any type of surgery; both more commonly reported among women (p = 0.002). Conclusion While there are limitations due to self-sampling, our study shows the feasibility of obtaining a large set of patient-reported data from adults who had childhood Perthes’ from multiple countries. Cite this article: Bone Jt Open 2022;3(5):404–414.
Autoencoder-based training for multi-illuminant color constancy
Authors: Vršnak Donik , Domislović Ilija , Subašić Marko , Lončarić Sven 
Published: May 2022

Color constancy is an essential component of the human visual system. It enables us to discern the color of objects invariant to the illumination that is present. This ability is difficult to reproduce in software, as the underlying problem is ill posed, i.e., for each pixel in the image, we know only the RGB values, which are a product of the spectral characteristics of the illumination and the reflectance of objects, as well as the sensitivity of the sensor. To combat this, additional assumptions about the scene have to be made. These assumptions can be either handcrafted or learned using some deep learning technique. Nonetheless, they mostly work only for single illuminant images. In this work, we propose a method for learning these assumptions for multi-illuminant scenes using an autoencoder trained to reconstruct the original image by splitting it into its illumination and reflectance components. We then show that the estimation can be used as is or can be used alongside a clustering method to create a segmentation map of illuminations. We show that our method performs the best out of all tested methods in multi-illuminant scenes while being completely invariant to the number of illuminants.
Field evaluation of the performance of seven Antigen Rapid diagnostic tests for the diagnosis of SARs-CoV-2 virus infection in Uganda
Authors: Bwogi Josephine , Lutalo Tom , Tushabe Phionah , Bukenya Henry , Eliku James Peter , Ssewanyana Isaac , Nabadda Susan , Nsereko Christopher , Cotten Matthew , Downing Robert , Lutwama Julius , Kaleebu Pontiano ,   EPI Laboratory team,   UVRI -COVID 19 Technical team
Published: May 2022

Objective
The objective of this study was to evaluate the performance of seven antigen rapid diagnostic tests (Ag RDTs) in a clinical setting to identify those that could be recommended for use in the diagnosis of SARS-CoV-2 infection in Uganda.

Methods
This was a cross-sectional prospective study. Nasopharyngeal swabs were collected consecutively from COVID-19 PCR positive and COVID-19 PCR negative participants at isolation centers and points of entry, and tested with the SARS-CoV-2 Ag RDTs. Test sensitivity and specificity were generated by comparing results against qRT-PCR results (Berlin Protocol) at a cycle threshold (Ct) cut-off of ≤39. Sensitivity was also calculated at Ct cut-offs ≤29 and ≤33.

Results
None of the Ag RDTs had a sensitivity of ≥80% at Ct cut-off values ≤33 and ≤39. Two kits, Panbio™ COVID-19 Ag and VivaDiag™ SARS-CoV-2 Ag had a sensitivity of ≥80% at a Ct cut-off value of ≤29. Four kits: BIOCREDIT COVID -19 Ag, COVID-19 Ag Respi-Strip, MEDsan® SARS-CoV-2 Antigen Rapid Test and Panbio™ COVID-19 Ag Rapid Test had a specificity of ≥97%.

Conclusions
This evaluation identified one Ag RDT, Panbio™ COVID-19 Ag with a performance at high viral load (Ct value ≤29) reaching that recommended by WHO. This kit was recommended for screening of patients with COVID -19-like symptoms presenting at health facilities.
Utilization of social health security scheme among the households of Illam district, Nepal
Authors: Shah Sanjeeb , Jha Nilambar , Khanal Vijay Kumar , Nepal Gurung Gyanu , Sharma Babita , Shrestha Mausam 
Published: May 2022

Background
Nepal has implemented the social health security program in certain health facilities to improve access to quality health services. The aim of the study is to understand the utilization pattern of social health security schemes and community’s perception of the social health security program.

Method
A descriptive cross-sectional mixed-method study was conducted among 300 households of Illam district who had enrolled in the social health security scheme. A multi-stage random sampling method was used. A semi-structured questionnaire was used to collect quantitative data whereas focus group discussions (FGDs) were conducted for qualitative data. Descriptive analysis, bivariate and multivariate analysis was done. FGDs were transcribed and thematic analysis was done.

Findings
The utilization rate of social health security scheme was 88.7%. Factors associated with the utilization of program included: presence of under-five children and chronic illness in households, sex and age group. Focus group discussion revealed that people were aware of social health insurance and pleased with program implemented by government. However, the hospitals under the social health insurance were not able to meet their expectations.

Conclusion
Although the utilization of social health security scheme was high, people were dissatisfied with the service provided by the hospital under the social health security scheme. Therefore, the social health insurance board should closely monitor the hospitals and develop a feedback mechanism from the users.
Factors influencing low-income households’ food insecurity in Bangladesh during the COVID-19 lockdown
Authors: Shuvo Suvasish Das , Hossain Md. Sakhawot , Riazuddin Md. , Mazumdar Sanaullah , Roy Deepa 
Published: May 2022

Background
The COVID-19 pandemic and countrywide lockdown could negatively impact household food insecurity among low-income households. This study aimed to investigate the prevalence of household food insecurity and its influencing factors among low-income people in Bangladesh during the lockdown of COVID-19.

Methods
This cross-sectional study was conducted through face-to-face interviews from 500 low-income households during the countrywide COVID-19 lockdown. A pretested, structured and validated questionnaire was used to collect socioeconomic characteristics, household income conditions, and food accessibility. Household Food Insecurity Access Scale (HFIAS) and Dietary Diversity Score (DDS) were used to measure food insecurity. Multinomial logistic regression models were estimated to evaluate and predict risk factors that influence food insecurity.

Results
The study found that above 67% of households was mild-to-moderate food insecure while 23% experienced severe food insecurity. Significantly, 88%, 97.4%, and 93.4% of the households had anxiety and uncertainty, inadequate quality, and inadequate quantity of food, respectively. The regression analysis revealed the age 36–50 years (RRR: 4.86; 95% CI: 2.31–7.44, RRR: 4.16; 95% CI: 2.25–6.10) and monthly income <58.3 USD (RRR: 3.04; 95% CI: 1.12–5.14, RRR: 3.26; 95% CI: 1.79–4.71) were significantly associated with food insecurity (p <0.001). Likewise, less-income (RRR: 3.87; 95% CI: 1.37–6.46, RRR: 2.99; 95% CI: 1.16–4.83), increase in food prices (RRR: 1.29; 95% CI: 0.32–2.33, RRR: 1.08; 95% CI: 0.05–1.12), and those who did not have same type of earning as before during the COVID-19 lockdown (RRR: 3.41; 95% CI: 1.33–5.62, RRR: 2.60; 95% CI: 0.99–4.24) were potential risk factor for MMFI and FI.

Conclusion
This study found that households become more susceptible to food insecurity during the COVID-19 pandemic and lockdown period. Based on the findings, we suggest some essential food policies and adequate food assistance to mitigate these negative consequences.
Factors associated with prevention practices against COVID-19 in the Peruvian population: Disparities between rural and urban areas
Authors: Fernandez-Guzman Daniel , Soriano-Moreno David R. , Ccami-Bernal Fabricio , Velasquez-Fernandez Randy , Morocho-Alburqueque Noelia , De-Los-Rios-Pinto Abraham , Coba-Villan Naomi , Diaz-Corrales Angelica , Pinedo-Soria Antony , Grados-Espinoza Pamela , Nieto-Gutierrez Wendy 
Published: May 2022

Objective
To determine the factors associated with prevention practices against COVID-19 in the Peruvian population according to rural vs. urban locations.

Methods
Analytical cross-sectional study, secondary analysis based on a previously collected database. A sample of individuals over 18 years of age, residing in Peru and with no history of COVID-19was evaluated. Factors associated with prevention practices were evaluated using Poisson regressions with variance adjustment by region cluster and stratified by rurality.

Results
Of 3231 participants included, 2741 (84.8%) were from urban areas and 490 (15.2%) from rural areas. The frequency of good prevention practices against COVID-19 was 27.8% in our total sample. In urban areas the frequency of good prevention practices was 28.8% and in rural areas it was 22.5%. Factors associated with prevention practices against COVID-19 in both urban and rural areas were male sex (urban: aPR 0.64, 95%CI 0.55–0.75; rural: aPR 0.66, 95%CI 0.54–0.80) and self-considering adequately carrying out prevention practices (urban: aPR 2.48, 95%CI 2.13–2.89; rural: aPR 2.70, 95%CI 2.27–3.19).

Conclusion
The frequency of good prevention practices against COVID-19 was less than 30% in both urban and rural areas. There are differences in the factors associated with good preventive practice against COVID-19. Only sex and considering that preventive measures were adequately carried out were associated with good prevention practices in both areas. In view of this, prevention measures should be promoted taking into account cultural principles and considering geographical location in the face of present and future outbreaks or pandemics.
The expression and prognostic value of toll-like receptors (TLRs) in pancreatic cancer patients treated with neoadjuvant therapy
Authors: Nurmi Anna Maria , Hagström Jaana , Mustonen Harri , Seppänen Hanna , Haglund Caj 
Published: May 2022

Objectives
Toll-like receptors (TLRs) play a pivotal role in the immune system and carcinogenesis. There is no research on TLR expression and association with survival among preoperatively treated pancreatic cancer patients. We studied the expression intensity and prognostic value of TLRs in pancreatic cancer patients treated with neoadjuvant therapy (NAT) and compared the results to patients undergoing upfront surgery (US).

Method
Between 2000 and 2015, 71 borderline resectable patients were treated with NAT and surgery and 145 resectable patients underwent upfront surgery at Helsinki University Hospital, Finland. We immunostained TLRs 1–5, 7, and 9 on sections of tissue-microarray. We classified TLR expression as 0 (negative), 1 (mild), 2 (moderate), or 3 (strong) and divided into high (2–3) and low (0–1) expression for statistical purposes.

Results
Among TLRs 1, 3, and 9 (TLR1 81% vs 70%, p = 0.008; TLR3 92% vs 68%, p = 0.001; TLR9 cytoplasmic 83% vs 42%, p<0.001; TLR9 membranous 53% vs 25%, p = 0.002) NAT patients exhibited a higher immunopositivity score more frequently than patients undergoing upfront surgery. Among NAT patients, a high expression of TLR1 [Hazards ratio (HR) 0.48, p<0.05] associated with a longer postoperative survival, whereas among US patients, high expression of TLR5 (HR 0.64, p<0.05), TLR7 (HR 0.59, p<0.01, and both TLR7 and TLR9 (HR 0.5, p<0.01) predicted a favorable postoperative outcome in separate analysis adjusted for background variables.

Conclusions
We found higher immunopositive intensities among TLRs 1, 3, and 9 in NAT patients. A high TLR1 expression associated with a longer survival among NAT patients, however, among US patients, high expression intensity of TLR5 and TLR7 predicted a favorable postoperative outcome in the adjusted analysis.
Imaging articular cartilage in osteoarthritis using targeted peptide radiocontrast agents
Authors: Fowkes Milan M. , Das Neves Borges Patricia , Cacho-Nerin Fernando , Brennan Paul E. , Vincent Tonia L. , Lim Ngee H. 
Published: May 2022

Background
Established MRI and emerging X-ray contrast agents for non-invasive imaging of articular cartilage rely on non-selective electrostatic interactions with negatively charged proteoglycans. These contrast agents have limited prognostic utility in diseases such as osteoarthritis (OA) due to the characteristic high turnover of proteoglycans. To overcome this limitation, we developed a radiocontrast agent that targets the type II collagen macromolecule in cartilage and used it to monitor disease progression in a murine model of OA.

Methods
To confer radiopacity to cartilage contrast agents, the naturally occurring tyrosine derivative 3,5-diiodo-L-tyrosine (DIT) was introduced into a selective peptide for type II collagen. Synthetic DIT peptide derivatives were synthesised by Fmoc-based solid-phase peptide synthesis and binding to ex vivo mouse tibial cartilage evaluated by high-resolution micro-CT. Di-Iodotyrosinated Peptide Imaging of Cartilage (DIPIC) was performed ex vivo and in vivo 4, 8 and 12 weeks in mice after induction of OA by destabilisation of the medial meniscus (DMM). Finally, human osteochondral plugs were imaged ex vivo using DIPIC.

Results
Fifteen DIT peptides were synthesised and tested, yielding seven leads with varying cartilage binding strengths. DIPIC visualised ex vivo murine articular cartilage comparably to the ex vivo contrast agent phosphotungstic acid. Intra-articular injection of contrast agent followed by in vivo DIPIC enabled delineation of damaged murine articular cartilage. Finally, the translational potential of the contrast agent was confirmed by visualisation of ex vivo human cartilage explants.

Conclusion
DIPIC has reduction and refinement implications in OA animal research and potential clinical translation to imaging human disease.
Efficacy of sanitization protocols in removing parasites in vegetables: A protocol for a systematic review with meta-analysis
Authors: Maia Cláudio Márcio de Medeiros , Damasceno Karla Suzanne Florentino da Silva Chaves , Seabra Larissa Mont’Alverne Jucá , Chaves Gabriela , Dantas Lívia Maria da Costa , de Sousa Júnior Francisco Canindé , de Assis Cristiane Fernandes 
Published: May 2022

Background
Parasitic contamination of vegetables is a public health problem in several countries and a challenge for food safety. With a short path from the field to the table, these foods can suffer several flaws in the good practices of production, transport and packaging which culminate in an offer of contaminated food to consumers. Therefore, this study describes a systematic review protocol with meta-analysis on evaluating the effectiveness of existing sanitation methods in removing parasites from vegetables.

Methods
The study will be conducted from published studies that report analyzes of parasites in vegetables before and after sanitization processes. The MEDLINE, Embase, Web of Science, FSTA, LILACS, Scopus and AGRIS electronic databases will be used. In addition, manual searches will be carried out through related articles, references to included articles and directories of theses and dissertations. The primary outcome will be the reduction or absence of parasitic forms in vegetables after the intervention or combined interventions, and the secondary outcomes will include: identification of the main parasites, assessment of the time required for processing and cost-effectiveness analysis. Two authors will independently screen the studies and extract data. Disagreements will be resolved by discussion, and a third reviewer will decide if there is no consensus. The criteria established by the Cochrane Manual (with some adaptations) will be used to assess the risk of bias in the studies and if the results are considered acceptable and sufficiently homogeneous, and a meta-analysis will be performed to synthesize the findings.

Discussion
The systematic review produced from this protocol will provide evidence on the effectiveness of sanitation protocols for removing parasitic forms in vegetables and will contribute to strengthening food safety, with the adoption of best sanitation practices and prevention of health risks. In addition, the study may highlight possible knowledge gaps that need to be filled with new research.

Systematic review registration
PROSPERO registration number: CRD42020206929.
Nauczanie języka sąsiada od przedszkola do zakończenia edukacji – kluczem do komunikacji w Euroregionie Pomerania. Założenia teoretyczne, cele i wstępne wyniki projektu
Authors: Bielicka Małgorzata , Olpińska-Szkiełko Magdalena 
Published: May 2022

The paper presents a report on the implementation of the educational project Teaching the neighbours’ language from kindergarten to the end of education - the key to communication in the Euroregion Pomerania co-financed by the European Regional Development Fund (ERDF) under the Interreg VA Cooperation Program Mecklenburg-Vorpommern/Brandenburg/Poland. 24 educational institutions in Poland and 33 educational institutions in Germany took part in the project. 3,771 children and 821 teachers and kindergarten educators participated in project events. The number of lessons conducted during the project was over 30,000. In addition to school education, the project covered numerous meetings of Polish and German children and youth, workshops for teachers, educational forums for parents and others. The project developed curricula for German as a language of the neighbours at all educational stages and in all types of Polish schools, as well as numerous multimedia teaching materials, such as educational games, worksheets, educational films, etc. This paper describes the project, its theoretical and practical foundations and its results.
A regularized gradient flow for the p-elastic energy
Authors: Blatt Simon , Hopper Christopher , Vorderobermeier Nicole 
Published: May 2022

Abstract
We prove long-time existence for the negative

L

2

{L}^{2}

-gradient flow of the p-elastic energy,

p
≥
2

p\ge 2

, with an additive positive multiple of the length of the curve. To achieve this result, we regularize the energy by cutting off the degeneracy at points with vanishing curvature and add a small multiple of a higher order energy, namely, the square of the

L

2

{L}^{2}

-norm of the normal gradient of the curvature

κ

\kappa

. Long-time existence is proved for the gradient flow of these new energies together with the smooth subconvergence of the evolution equation’s solutions to critical points of the regularized energy in

W

2
,
p

{W}^{2,p}

. We then show that the solutions to the regularized evolution equations converge to a weak solution of the negative gradient flow of the p-elastic energies. These latter weak solutions also subconverge to critical points of the p-elastic energy.