bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalencia y factores asociados a trastornos musculoesqueléticos en una población recolectora de café del municipio de Betania- Antioquia. 2019
Authors: Ramírez Jaramillo Paulina , Bonilla Mendoza Laura Fernanda , Buitrago Salazar Jesy Carolina , Múnera Ramírez Sara , Uribe Quintero María Lucía , Noguera Cabrales María Daniela , Molina Restrepo Isabel , Garzón Duque María Osley 
Published: July 2022

Introducción: Los recolectores de café son una población vulnerable, sin embargo, es escasa la evidencia de sus condiciones socio-laborales y trastornos musculoesqueléticos (TME). Objetivo: describir las condiciones sociodemográficas, laborales, el riesgo ergonómico y su relación con los TME en recolectores de café del municipio de Betania, Antioquia, 2019. Materiales y métodos: Estudio transversal con intención analítica y fuente primaria de información. Se incluyeron 98 recolectores de café, mayores de edad, laborando en el municipio de Betania. Se aplicó un instrumento estandarizado, previa toma de consentimiento a cada trabajador. Fueron incluidas condiciones sociodemográficas, laborales, el método OWAS para tamizar factores de riesgo posturales y el cuestionario nórdico para identificar sus TME. Resultados: El 56% de los participantes presentó mínimo un TME, siendo la lumbalgia la más prevalente, un 34,7% presentó posturas con efectos dañinos. Se identificó mayor reporte de cervicalgia en trabajadores con ≥51 años. Quienes tuvieron un accidente laboral presentaron casi 4 veces más prevalencia de síndrome del manguito rotador. Fueron significativas las asociaciones entre las condiciones laborales y fascitis plantar, manguito rotador y túnel del carpo. Conclusión: las condiciones laborales y riesgos posturales asociadas a los TME pueden ser modificadas con acciones de prevención orientadas a mejorar las condiciones de vida y salud de los recolectores.
Aromatic Amino Acids: Phenylalanine and Tyrosine in Patients with Hypertension and Coronary Artery Disease
Authors: Krivova A. V. , Kozhevnikova M. V. , Korobkova E. O. , Zektser V. Yu. , Zheleznykh E. A. , Ageev А. A. , Moskaleva N. E. , Kukharenko A. V. , Appolonova S. A. , Belenkov Yu. N. 
Published: July 2022

Aim. To evaluate changes in the profile of aromatic amino acids (AAA) in patients with cardiovascular diseases (CVD): hypertension and coronary artery disease (CАD) in comparison with healthy study participants.Material and methods. One hundred and thirty-one participants were included in the study: 58 participants were included in the hypertension group, 46 in the CАD group, and 27 participants without signs of CVD in the control group. We used ultrahigh-performance liquid chromatography in combination with a triple quadrupole analyzer to measure plasma AAA: phenylalanine and tyrosine (Phe, Tyr) in all study participants. The association of AAA with biochemical blood test parameters, echocardiography (EchoCG) parameters, blood pressure level and clinical characteristics was analyzed.Results. A statistically significant difference in the level of concentration of Phe and Tyr was revealed (p=0,002 and p=0,024, respectively), comparing the three groups. Post-hoc analysis showed differences in the circulating level of both amino acids in patients with CAD vs the control group (Phe p=0,008 and Tyr p=0,020). Also a statistically significant difference in the level of Phe of the hypertension and CАD groups (p=0,017) was found. A negative correlation of low-density lipoproteins (LDL) with the level of Phe (r=-0,685, p<0,05) and Tyr (r=-0,583, p<0,05), as well as the level of Phe with total cholesterol (r=-0,461, p<0,05) was found in the group without CVD. In the hypertension group, only a weak positive correlation was found between very low-density lipoproteins and AAA levels (Phe r=0,326 and Tyr r=0,365, p<0,05), while in patients with CAD, the level of Phe and Tyr was negative correlated with high-density lipoprotein (r=-0,378 and r=-0,543, respectively, p<0,05), and the level of Tyr with LDL (r=0,349, p<0,05). When isolating the group with proven atherosclerosis of peripheral and/or coronary arteries, a statistically significant difference was revealed between the group of patients with CVD and clinical and instrumental signs of atherosclerosis and the group of patients with CVD without proven atherosclerosis in Phe level (p=0,019).Conclusion. Concentrations of AAA were higher in patients with CVD, comparing with the control group. At the same time, an increase of the Phe level was associated with the presence of peripheral or coronary atherosclerosis. The revealed correlations of AAA with EchoCG parameters and lipid spectrum parameters require further study to understand the involvement of AAA in pathogenesis of CVD and its potential role as treatment target.
Acute Kidney Injury after Transcatheter Aortic Valve Implantation
Authors: Kremneva L. V. , Gapon L. I. , Shalaev S. V. , Krasheninin D. V. 
Published: July 2022

Aim. The aim of the study was to evaluate the incidence and predictors of acute kidney injury (AKI) associated with transcatheter aortic valve implantation (TAVI).Material and methods. 50 patients (39 women, 11 men) aged 76 (71; 80) years who underwent TAVI were examined. One day after TAVI, blood creatinine level was determined by the Jaffe method and troponin I by a highly sensitive method (hs-cTnI). Acute kidney injury (AKI) was diagnosed according to the KDIGO criteria (2012). The following hospital complications were evaluated: cases of cardiac death, intraoperative myocardial infarction (MI), stroke and transient ischemic attack, permanent pacemaker implantation, recurrent paroxysms of atrial fibrillation.Results. History of MI had 22% of patients, percutaneous coronary intervention – 38%, hypertension – 98%, chronic kidney disease – 48%, diabetes mellitus – 24%, class II NYHA of chronic heart failure (CHF) – 52%, NYHA class III – 46%, NYHA class IV – 2%. The risk of operational mortality according to EuroSCORE II was 6.3±5.4%. AKI after TAVI was registered in 6 (12%) patients (1 grade AKI – 8%, 2 grade – 2%, 3 grade – 2%). Parameters associated with AKI after TAVI were higher CHF NYHA class (p=0,020), high hs-cTnI level (p=0,013), intraoperative MI (p=0.035). The predictor of AKI after TAVI was high hs-cTnI level (odds ratio 4.0, 95% confidence interval 1.0-16.1). Among patients with AKI after TAVI in compare with patients without AKI, the cumulative frequency of cardiac death, MI, strokes and transient ischemic attacks, implantation of a permanent pacemaker, the proportion of people with paroxysmal atrial fibrillation during the hospital stay was 5,8 times higher (66.7% vs 11.4% respectively, p=0.001).Conclusion. AKI after TAVI was present in 12% of patients. The predictor for AKI development was an increase in hs-cTnI level after TAVI implantation. The hospital prognosis after TAVI is worse in patients with postoperative AKI.
EDITORIAL: Empreendedorismo de Base Universitária como Motor da Inovação
Authors: ZAAK SARAIVA Illyushin , Butzen Eduardo , Antonello Ricardo 
Published: July 2022

Esta edição do Caderno de Propriedade Intelectual e Transferência de Tecnologia, dando continuidade ao propósito de disseminar a inovação tecnológica tanto no que diz respeito ao nível micro, na forma de novos produtos, processos e serviços de base tecnológica, quanto, no nível macro, expresso em novos métodos de análise e solução dos problemas da realidade, vem premiar esforços de pesquisadores das mais diversas áreas publicando um grupo de trabalhos de alta qualidade, fruto da criatividade e do rigor metodológico de equipes de investigação abstrata e times de pesquisa aplicada espalhados por todo o território nacional.
Desde seu surgimento em 2019, a revista traz o compromisso de mesclar os frutos do ecossistema de inovação de Luzerna-SC – um dos mais vibrantes do país, e que levou esta cidade a ser considerada naquele mesmo ano como o município com o maior número de Startups por habitante do Brasil (RODRIGUES, 2019) – com os resultados de projetos de pesquisa os mais diversos e oriundos de todas as áreas do conhecimento, conforme a política editorial da publicação.
Assim, tem-se nesta edição de junho de 2021 do caderno a oportunidade de apresentar artigos de análise socioeconômica relativos às realidades local e nacional, bem como trabalhos apresentando novos processos, novos produtos e serviços desenvolvidos por brasileiros, no seio de instituições brasileiras, assim demonstrando-se novamente o gigantesco potencial de inovação do povo brasileiro, no qual se depositam esperanças de um futuro cada vez mais grandioso em termos do desenvolvimento técnico-científico, aliado à mudança para nova sustentabilidade ambiental.
Target-Hitting Probability Prediction of Landing Point for a Horizontal Well
Authors: Yin Hu , Jiang Xinghong , Li Qian , Gao Jiajia 
Published: July 2022

Summary
The uncertainties of the reservoir depth and wellbore position derived from the measurement error of the well trajectory means that entering the landing point of a horizontal well is challenging. In many cases for horizontal well trajectory control, the influence of depth error on the target probability is not considered because methods of analyzing the effects of position uncertainty quantitatively are lacking. This study considers the effects of uncertainty of the wellbore position and that of the vertical depth of the reservoir on the horizontal well in terms of hitting a target. We assume that the wellbore position and target depth conform to the law of normal distribution. Accordingly, a horizontal well target-hitting probability prediction model is established. With the four aspects of random, system, well-by-well and global errors considered, 14 error sources and error weight functions that affect the measurement depth are first determined. The error theory is then used to establish a calculation model for the error of measurement depth as well as a method for predicting the probability of hitting the landing point in a horizontal well. This method not only can be used to predict the target-hitting probability of the landing point, but it can also be used to analyze various factors that affect the target entry in the horizontal well. This research also provides a theoretical basis for selecting marker beds and conducting well trajectory design to effectively improve the target-hitting probability in horizontal wells.
Digitalization strategy for personalized dental medicine: A case study on orthodontic service
Authors: Tsai I-Ching , Wei Hui-Chi , Chen Peng-Ting 
Published: July 2022

Abstract
Background:
Digital technologies are increasingly being used in medical practice to improve the doctor–patient relationship. Patient communication exerts a significant impact on the effect of orthodontic treatment and patient satisfaction. However, how medical providers can implement digital transformation with limited resources in digital technologies to achieve the best benefits is yet unknown. The aim of this study was to clarify the digital transformation framework in the context of the orthodontic process and understand the needs and desires of various stakeholders to help dentists formulate optimal digital transformation strategies of personalized dental medicine.
Methods:
A review of the literature related to the orthodontic process and interviews with relevant stakeholders were conducted. Content analysis was subsequently performed to construct an evaluation framework of the digital transformation of the orthodontic service. Finally, desire–requirement analysis (DRA)-NRM was performed.
Results:
This research constructed an evaluation framework of the digital transformation of four procedures, namely, clinical evaluation (CE), therapeutic communication (TC), orthodontic treatment (OT), and patient tracking (PT). The questionnaires were obtained from orthodontic digital transformation stakeholders, including dentists, digitalization solution providers (i.e., manufacturers), and patients. DRA-NRM analysis results revealed that TC was classified as the focus strategy and considered the most important stage of digital transformation. CE is considered to be the transformation strategy, and OT was a promotional strategy. Finally, PT was a deduction strategy.
Conclusions:
This research adopts the perspective of orthodontics-based digital stakeholder perspective to propose an evaluation framework that can provide strategic and reliable advice on the implementation phase for digital transformation in personalized orthodontic service. The results of this research could help dental develop effective digital strategies to improve doctor-patient relationships and use limited resources effectively to achieve optimal personalized dental medicine.
Rapid epidemic expansion of the SARS-CoV-2 Omicron BA.2 subvariant during China’s largest outbreaks
Authors: Dai Yeyu Freddie , Dai Bingxi Gabriel , Chen Mu 
Published: July 2022

Abstract
A complete and accurate statistical analysis of cases of contraction with SARS-CoV-2, under the conditions of strict mandatory quarantine and isolation and of a high rate of full vaccination, during the largest COVID-19 outbreaks driven by the Omicron BA.2 subvariant in China are given. SARS-CoV-2 is still new, and little is known about either its directions of variations or its laws of reproduction. No country other than China has been able to disclose every case of infection in every epidemic or outbreak since April of 2020. Here, this study reveals that Omicron BA.2 subvariant can still spread very fast and wide in areas with strict “dynamic zero-COVID strategy”1 in China, that there exist cities twenty-fold differences in morbidity rates unrelated to any of the known factors contributing to incidence of infectious diseases, and that Omicron BA.2 subvariant is unpredictable in its virulence, although the rate of severe confirmed cases is low. This study provides first-hand original and valuable information for further research on similar epidemics in the future and raises discussions about the possible correlation related to quantum effects and about the quantum evolution of SARS-CoV-2 Omicron variant which may finally bring COVID-19 Pandemic to end. It may bring new thoughts for correction of present epidemiological theory and mathematical models. It may also give other countries time to be better prepared for the coming waves driven by Omicron variant.
Integration of Smoking Cessation Into Standard Treatment for Patients Receiving Opioid Agonist Therapy Who Are Smoking Tobacco: Protocol for a Randomised Controlled Trial (ATLAS4LAR)
Authors: Druckrey-Fiskaaen Karl Trygve , Furulund Einar , Daltveit Jan Tore , Vold Jørn Henrik , Lid Torgeir Gilje , Madebo Tesfaye , Fadnes Lars Thore 
Published: July 2022

Abstract
Background: About 85% of patients receiving opioid agonist therapy (OAT) for opioid dependence are smoking tobacco. Although smoke-related pulmonary diseases are significant contributors to morbidity and mortality, few smoking cessation interventions are evaluated within this group, and few OAT patients are offered smoking cessation as an integrated part of their addiction treatment. This study protocol describes an integrated smoking cessation intervention aimed at patients receiving OAT and smoking tobacco.Methods: This is a multicentre, randomised controlled clinical trial that will recruit 266 daily tobacco smoking patients receiving OAT in OAT outpatient clinics in Bergen and Stavanger, Norway. The patients randomised for the intervention arm will be offered smoking cessation therapy consisting of weekly brief behavioural interventions and prescription-free nicotine replacement products. In the control arm, patients will receive standard care without any added interventions related to smoking cessation.The smoking cessation intervention includes psychoeducational techniques with components from motivational interviewing, and nicotine replacement products such as nicotine lozenges, patches and chewing gum. The duration of the intervention is 16 weeks, with the option of extending it with a further eight weeks. The main outcomes are measured at 16 weeks after initiation of the intervention, and sustained effects are evaluated one year after intervention initiation. The primary outcome is smoking cessation verified by carbon monoxide (CO)-levels or at least a 50% reduction in the number of cigarettes smoked. Secondary outcomes are changes in psychological well-being, biochemical inflammation markers, changes in physical health functioning, quality of life and fatigue. Discussion: Integration of other treatments to standard OAT care improves adherence and completion rates providing another rationale for integrated smoking cessation treatment. Thus, if integrated smoking cessation treatment is superior to standard care, this trial provides important information on further scale-up. Trial registration: ClinicalTrials.gov NCT05290025, Date of registry 22. March 2022
The Wide Range of Uses of Indocyanine Green in Thoracic Surgery: State-of-the-art
Authors: marziali valentina , Frasca Luca , Longo Filippo , Vega Raffaella , Crucitti Pierfilippo 
Published: July 2022

Abstract
Background: Thoracic surgery is a constantly evolving field that require innovative solutions. Invisible near-infrared fluorescence imaging with indocyanine green is an intraoperative technology that could be help for surgeons. Indocyanine green is a nontoxic dye with low rate of adverse reaction. Indocyanine green binds with plasma proteins and lipoprotein that allow a deep tissue penetration, and also the amphiphilic proprieties allow indocyanine green to migrate within lymphatics. Methods: We selected forty-nine previous studies from the literature searching terms “lung cancer”, “indocyanine green”, “thoracic surgery”, “fluorescent images”. The topics of the paper were: sentinel lymph node mapping, pulmonary nodes identification, intersegmental plane identification, and other application (pulmonary bullous lesions, bronchopleural fistula, bronchoplasty, pulmonary sequestration, chyle leak, hyperidrosis). Results: In the different applications indocyanine green showed a high identification rate, overall accuracy, sensibility, and specificity. Conclusions: This review describes the advantages and current applications in thoracic surgery of intraoperative near-infrared fluorescence imaging using indocyanine green.
Quantitative evaluation method of smoke exhaust performance and application on exhaust volume optimization in tunnel fires under lateral centralized mode
Authors: Zhu Daiqiang , Xu Pai , Xing Rongjun , Guo Yufei , Liu Yixian , Jiang Shuping , Li Linjie 
Published: July 2022

Abstract
The indicators in the quantitative method are investigated to evaluate smoke exhaust performance in tunnel fires, which provides a theoretical basis for the optimization of the smoke extraction system under the lateral centralized mode. The criterion is proposed for plug-holing, and the theoretical models of smoke exhaust efficiency are established to distinguish whether the plug-holing occurs or not. The relationship between efficiency, effectiveness, and efficacy is analyzed from the perspective of smoke and heat exhaust. Meanwhile, this evaluation method is applied to the optimization of exhaust volume through FDS numerical simulation. The results show that Ri is a vital basis for judging the movement form of smoke and the exhaust effect. The critical value of Ri is 1.09 when plug-holing occurs, resulting in a significant reduction in the efficiency of smoke exhaust. The greater the exhaust volume of the exhaust fan, the greater the Ri value, the higher the total smoke and heat exhaust efficiency, and the better the exhaust effectiveness of smoke inlets without plug-holing. Under longitudinal ventilation, the optimal exhaust volume is 180m3/s at 20MW and 360m3/s at 50MW.
Entirely recyclable all-organic electronics enabled by closed-loop recycling for the sustainable future wearable systems
Authors: Park Haechan , Kim Sehyun , Lee Juyeong , Lee Inwoo , Bontapalle Sujitkumar , Na Younghoon , Sim Kyoseung 
Published: July 2022

Abstract
With growing interest and effort in developing organic electronics for future technologies such as wearable electronics, organic e-wastes generated during synthesis and disposal are becoming an inevitable environmental issue. Organic e-wastes possess unforeseeable potential genotoxicity and cytotoxicity in nature and humans, but efforts to reduce e-wastes have primarily focused on recapturing metallic materials. Here, we report a recyclable organic flexible (ROF) electronic device enabled by closed-loop recycling of entire materials recapturing and reusing through selective dissolution and spin-coating-free fabrication. The ROF electrode and electronics show reliable electrical properties under mechanical bending and after five times recycling. Moreover, ROF transistors and logic gates based on organic semiconductors and dielectrics were fabricated, and recycled devices show no considerable degradation. Finally, we achieved the sustainable devices cycle by reconstructing various ROF electronics using only recycled materials from different functional devices. The ROF electronics in this work provide a promising strategy for a sustainable future wearable electronic system.
Evaluation of Soil Liquefaction Caused by Earthquakes With Design Program Soilengineering Using Synthetic Data
Authors: Aytaş Zeval , Alpaslan Nuray , Özçep Ferhat 
Published: July 2022

Abstract
Dynamic loads, such as earthquakes, can cause damage to soils, especially from soil liquefaction. Liquefaction analyses provide more reliable results when combined with the properties of soils and earthquakes. In recent years, computer programs have been developed in which many parameters can be used to perform these analyses for solving geotechnical engineering problems. SoilEngineering is a Microsoft Excel-based geotechnical design program with which calculations can be carried out and graphical results can be achieved based on empirical relationships. In this study, the effects of soil and earthquake parameters on soil liquefaction were analyzed using a standard penetration test (SPT) and shear wave velocity (Vs). We observed that there is conformity between the parameters used in different techniques. Taken together, our results show that calculating the liquefaction risk using both soil and earthquake properties will produce reliable results in solving geotechnical problems.
TCF-7 differentially regulates CD4 T cells mediated alloimmunity
Authors: Harris Rebecca , Mammadli Mahinbanu , Suo Liye , Sen Misra , Karimi Mobin 
Published: July 2022

Abstract
The transcription factor T Cell Factor-7, encoded by TCF-7, is critical for T cell development. However, the role of TCF-7 on peripheral CD4 T cell-mediated alloimmunity is currently unknown. In this report using a clinically relevant model, we presented novel findings on how TCF-7 regulates CD4 T cell functions, including CD4 T cell activation, phenotype, and effector and central memory formation. We uncovered how TCF-7 regulates chemokine receptors, which are essential for CD4 T cell migration to the site of inflammation. We provide molecular, and transcriptomic evidence that TCF-7 functionally regulates CD4 T cell-mediated apoptosis and cell death, T cell-mediated processes, and proinflammatory and anti-inflammatory cytokine production, differentiation at baseline and after alloactivation. These novel findings represent a step forward to designing a target-specific approach for CD4 T cell-mediated diseases, while enhancing understanding of the molecular mechanism behind the role of CD4 T cells in alloimmunity.