bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remission of metastasis lymph nodes cancer arising from malignant ovarian tumor composed of prominent papillary architecture: A case study
Authors: Thakur Alok 
Published: November 2022

PURPOSE: Incidence of clinically obvious and occult lymph node metastasis varies in the range from 12 to 48 percent. It is the seventh most deadly cancer among women in the world. Complementing chemotherapy with alternative medicine in lymph node carcinoma is perhaps the first time.

PATIENT AND METHODS: A 29-year-old woman subject was diagnosed with ovarian carcinoma in 2014. Subsequently, lesions in two lymph nodes were reported after about a year of the hysterectomy procedure. These two lesions continue to grow despite several chemo and radiation therapy cycles. Alternate medicine was adopted to complement traditional chemotherapy in October 2020.

RESULTS: Two months later in December 2020 CT scan exhibited huge regression in the sizes of both lesions developed over five years. The larger lesion in the para-aortic region regressed by 80.36% and the smaller lesion in the external iliac region was by 13.33%. The side effects of chemo were also not as harsh as before. Treatment was stopped in March 2022 after the CT scan showed complete remission of both lesions. A follow-up CT scan in October 2022 showed no reoccurrence of lesions. These results give a big hope for a final kill of the lymph node carcinoma. Figure 1 shows the graphical representation of the case.

CONCLUSION: It is a monumental success in the treatment of metastasis lymph node carcinoma. Though alternate medicine was used along with traditional chemotherapy, it is definite that regression happened for the first time in the intervening five years. Thus, demonstrating a strong positive supporting role of homeopathic dilutions in the regression and completer remission of metastasis lymph nodes carcinoma. The treatment is inexpensive and free from side effects. The present treatment opens new vistas to treat lymph node carcinoma and perhaps other cancers like OC and breast cancer.
Acrostic in Byzantine Hymnography and Slavonic Spiritual Poetry in Byzantine Hymnography
Authors: Syrotynska Natalia 
Published: November 2022

The purpose of the work is to investigate the functioning of the acrostiс verse in various contexts of the spiritual culture of the European space. This ancient form is used in Old Testament poetry, Byzantine hymnography, Ukrainian sacred monody and spiritual song. The methodological basis is the application of systemic and complex approaches, which ensured the establishment of valuable social and cultural functional elements within the historical development of mankind. The use of comparative method of research contributed to the identification of structural models that ensured the integrity and systematicity of the evolution of culture on the example of form-forming structures. In this context, we also use the heuristic method of research, which contributes to the modeling of structural connections within cultural and artistic forms. The use of the specified research methods contributed to obtaining own theoretical results. The scientific novelty of the study is determined by the originality of the theoretical principle of comparing the form of the acrostic in different genres over time intervals. Conclusions. The ways of arranging poetic texts, which laid the foundations of Byzantine hymnography, are a complex system formed on the basis of ancient metrical and melodic constructions. The acrostic became the evidence of the adaptation of such experience of ancient forms of poetry – as a source of a number of important form-creating processes. The long-term use of the acrostic is evidence of the use of liturgical experience in the context of synthesising the “technological developments” of ancient cultures and singling out among them the most functional, in particular, the acrostic.
Key words: acrostiс, Byzantine hymnography, sacred monody, baroque poetry, Bohohlasnyk, spiritual song.
Domestic Guitar School: Historical Heritage of Performance Traditions and Development Prospects
Authors: Tushchenko Mykhaylo 
Published: November 2022

The purpose of the article is to analyse the problems of historical heredity of performing traditions of the domestic guitar school and to provide a generalised view of the prospects for the development of guitar art in the domestic cultural and educational space in the context of the guitar evolution. Research methods. Historical-theoretical and executive analyses were used to solve the tasks of the research. Scientific novelty. This paper is a highlight of the specifics of performing traditions and national schools, as well as the results of the analysis of prospects for the development of the domestic guitar school in modern conditions. There is an attempt to shed light on the current “postmodern” artistic situation in Ukraine. Conclusions. The article covers the history of the guitar origin as a professional musical instrument and the history of performance on the classical guitar in Ukraine in the context of the influence of Western European performing culture. The development of guitar schools is analysed in tertiary artistic establishments of Ukraine, a guitar art is considered within the framework of actual postmodern discourse and in the context of development of world guitar art.
Key words: Ukrainian guitar school, guitar art, guitar, performing tradition, performing school, historiogenesis of guitar art.
G. Bizet’s “The Pearl Fishers” in the context of Poetics of French Lyrical Opera
Authors: Yuheng Lin 
Published: November 2022

The purpose of the study is to reveale the poetic and intonation uniqueness of G. Bizet’s “The Pearl Fishers” in the context of the genre-style canon of French lyric opera. The methodology of the work has a complex nature and is based on a combination of the principles of cultural, historical-typological, hermeneutic, and genre-intonation studies. The scientific novelty of the work is determined by the fact that it examines for the first time the genre-stylistic and spiritual-meaning specifics of G. Bizet’s “The Pearl Fishers” in the realm of the poetics of French lyric opera. Conclusions. Lyrical opera is a bright stage in the development of French musical theatre in the middle and second half of the 19th century. The opposition of this genre in relation to “grand” opera at the same time does not exclude their mutual influence, which is manifested in the antitheses of the personal drama of the main characters, ennobled by a high sense of love, and the patriarchal instructions of the environment in which they are. This also determined the stylistic specificity of lyric opera, formed at the intersection of romantic and Biedermeier traditions. The mysterious genesis of the European musical theatre was reflected in the lyric opera in the potential direction of the fate of its main characters towards spiritual transformation. G. Bizet’s romantic-exotic opera “The Pearl Fishers”, created in 1863, is based on the dramatic story of a priestess who broke her vow and her lucky escape from punishment. The genre canon of the lyric opera is manifested in the named opera in the appeal to the oriental plot, in the presence of a traditional love drama for lyric opera, which is in contradiction with the generally accepted patriarchal norms of the spiritual and religious order, which are dominant in the society in which the main characters live, in a significant the role of genre scenes, which generally reproduce within the framework of the European musical tradition, without corresponding folklore quotes, the exotic flavour given by the plot (fifth-note bourdons, the essential role of the metro-rhythmic factor and the timbre of percussion, the figurative-improvisational type of the vocal part of Leila the priestess).
Key words: musical culture of France of the 19th century, French lyric opera, musical theatre by G. Bizet, “The Pearl Fishers” by G. Bizet.
IMPLEMENTASI PROGRAM PARENTING DI KOBER CERDAS CERIA KOTA SERANG
Authors: Windiyanti Titi , Fahmi Fahmi , Sayekti Tri 
Published: November 2022

This study aims to describe 1) parenting program implementation 2) benefits of parenting programs 3) supporting factors and inhibiting factors of parenting programs. The subjects of this study were principals, teachers and parents. Data collection using observation, interview and documentation techniques. The techniques used in data analysis are data reduction, data presen tation and conclusion drawing. Validity of data conducted to explain data using extended research, triangulation, membercheck and adequacy of references. The results showed that 1) The parenting program is carried out every three months with stages of planning, implementation and evaluation. Each theme is different, the first is about socializing school programs, the second is about maintaining the nutritional health of children and the third is about parenting in the digital era 2) this parenting program provides several benefits to respondents. 3) supporting factors include the enthusiasm of the participants, the solidarity of the committee, adequate facilities and infrastructure and the implementation time is not too long. Inhibiting factors include the lack of participants and the lack of school socialization.
Keywords: parenting program; kober cerdas ceria serang city
ANALISIS PEMAHAMAN KONSEP IPS MATERI KEBERAGAMAN BUDAYA BANGSAKU PADA SISWA KELAS IV DI SD NEGERI 18 LAHAT
Authors: Okpiani Seli , Aryaningrum Kiki , Kuswidyanarko Arief 
Published: November 2022

Tujuan penelitian ini adalah (1) untuk Untuk mengetahui tingkat kemampuan pemahaman konsep IPS materi keragaman budaya bangsaku pada siswa kelas IV di SD Negeri 18 Lahat serta (2) Untuk mengetahui Peranan guru terhadap pemahaman konsep IPS materi keragaman budaya bangsaku pada siswa kelas IV di SD Negeri 18 Lahat.Metode pengumpulan data yang digunakan metode dokumentasi, wawancara, dan tes. Data yang diperoleh dianalisis dengan menggunakan metode analisis data deskriptif kualitatif.Hasil dari penelitian ini yaitu dapat terlihat dari kategori 75% sangat baik berjumlah 15 siswa, dalam kategori 15% baik berjumlah 3 siswa, dalam kategori 10% cukup bejumlah 2 siswa dan gagal berjumlah 0, maka nilai rata-rata tingkat pemahaman konsep IPS sebesar 80 yang termasuk kedalam kategori baik. Dari hasil analisis data diatas, dapat disimpulkan bahwa pemahaman konsep materi keberagaman budaya bangsaku pada siswa kelas IV SD Negeri 18 Lahat sudah baik dan terdapat peranan guru dalam pemahaman konsep IPS materi keragaman budaya bangsaku pada siswa kelas IV di SD Negeri 18 Lahat.
Prevalence Of Migraine Among Headache Patient In Muzaffarabad
Authors: Qadeer Ummara 
Published: November 2022

Background: Migraine is a most common, progressive and sometimes incapacitating disorder. Symptoms of migraine may include nausea, vomiting, photophobia (sensitivity to light), phonophobia (sensitivity to sound) and usually a short period of visual disruption occur. Objective: To find the prevalence of migraine among headache patient in Muzaffarabad. Methods: Cross-sectional study design, 700 patients with headache were recruited in the study and measured by questionnaire “International classification of headache disorder diagnostic criteria for migraine”. Results: The Prevalence of migraine among headache patient was 40%.Conclusion: It is concluded from the results of this study, that out of 700 studyparticipants 40% (281) participants are suffering from migraine and they wereunaware of this.

Keywords: Migraine, Headache
The Power of Language Learning Beyond the Classroom to English Mastery of an EFL Learner
Authors: Hariyanti Yuni , Purwandari Junita Duwi 
Published: November 2022

Language learners have come to an era in which studying outside the classroom is well-facilitated by technology development. Along with this advancement, there is a wider chance to learn things outside the classroom, including language. In the Indonesian context, many students have done wider exploration to improve their English exposure through various activities. This study aims to reveal the learning strategies done by a successful EFL learner through case study research. The result shows that online games, e-books, and movies are some of the prominent learning tools of Language Learning Beyond the Classroom (LLBC) to enhance language exposure and learners’ autonomy.
Platelet CD36 links overweight and a prothrombotic phenotype in patients with non-valvular atrial fibrillation
Authors: Wang Hua , Yan Wei-hong , Gong Lei , Song Nian-peng , Wang Chun-xiao , Zhong Lin 
Published: November 2022

IntroductionThe pathophysiological mechanisms linking the overweight and prothrombotic state of non-valvular atrial fibrillation (NVAF) are incompletely understood. Our objective was to evaluate the effect of platelet CD36 on the risk of stroke associated with overweight in NVAF patients.MethodsA cross-sectional study enrolled 182 subjects with NVAF in two groups: normal weight (18.5 &lt; body mass index(BMI) &lt; 25.0 kg/m2) and overweight (BMI ≥ 25.0 kg/m2). Clinical data, medical history, vital signs, transthoracic echocardiography parameters, and medication were recorded. Biochemical characteristics including blood glucose and serum lipid were analyzed in the Laboratory.ResultsThe expression of platelet CD36 and integrin αIIbβ3 was detected by flow cytometry. Among the 182 patients with NVAF, 68 (37.36%) were classified as normal weight, 114 (62.64%) as overweight. With an increase in BMI, waist-hip ratio, cholesterol, triglycerides, left atrium diameters, and the ratio of mitral inflow E velocity to myocardial e' velocity in the mitral annulus (E/e') increased significantly (P &lt; 0.05). The mean fluorescent intensity of platelet CD36 increased significantly in overweight patients (P &lt; 0.01), in line with platelet activation biomarkers (platelet integrin αIIbβ3). Platelet CD36 was positively correlated with BMI and platelet integrin αIIbβ3, respectively (P &lt; 0.05). Additionally, platelet CD36 and BMI were independent risk factors for platelet activation in patients with NVAF.ConclusionsPlatelet CD36 is speculated to mediate the complex crosstalk between overweight and platelet hyperactivity, leading to the prothrombotic state in overweight patients with NVAF. Platelet CD36 could be a potential target for preventing the prothrombotic state in overweight patients with NVAF.
Network pharmacology and molecular docking-based analysis of protective mechanism of MLIF in ischemic stroke
Authors: Lv Mengting , Zhu Qiuzhen , Li Xinyu , Deng Shanshan , Guo Yuchen , Mao Junqing , Zhang Yuefan 
Published: November 2022

ObjectiveThis study aimed to evaluate the potential mechanism by which Monocyte locomotion inhibitory factor (MLIF) improves the outcome of ischemic stroke (IS) inflammatory injury.MethodsPotential MLIF-related targets were predicted using Swiss TargetPrediction and PharmMapper, while IS-related targets were found from GeneCards, PharmGKB, and Therapeutic Target Database (TTD). After obtaining the intersection from these two datasets, the Search Tool for Retrieval of Interacting Genes/Protein (STRING11.0) database was used to analyze the protein-protein interaction (PPI) network of the intersection and candidate genes for MLIF treatment of IS. The candidate genes were imported into the Metascape database for Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The top 20 core genes and the “MLIF-target-pathway” network were mapped using the Cytoscape3.9.1. Using AutoDock Vina1.1.2, the molecular docking validation of the hub targets and MLIF was carried out. In the experimental part, transient middle cerebral artery occlusion (tMCAO) and oxygen and glucose deprivation (OGD) models were used to evaluate the protective efficacy of MLIF and the expression of inflammatory cytokines and the putative targets.ResultsMLIF was expected to have an effect on 370 targets. When these targets were intersected with 1,289 targets for ischemic stroke, 119 candidate therapeutic targets were found. The key enriched pathways were PI3K-Akt signaling pathway and MAPK signaling pathway, etc. The GO analysis yielded 1,677 GO entries (P &lt; 0.01), such as hormone stimulation, inflammatory response, etc. The top 20 core genes included AKT1, EGFR, IGF1, MAPK1, MAPK10, MAPK14, etc. The result of molecular docking demonstrated that MLIF had the strong binding capability to JNK (MAPK10). The in vitro and in vivo studies also confirmed that MLIF protected against IS by lowering JNK (MAPK10) and AP-1 levels and decreasing pro-inflammatory cytokines (IL-1, IL-6).ConclusionMLIF may exert a cerebral protective effect by inhibiting the inflammatory response through suppressing the JNK/AP-1 signaling pathway.
Integrative metabolic analysis of orbital adipose/connective tissue in patients with thyroid-associated ophthalmopathy
Authors: Huang Jiancheng , Chen Meng , Liang Yu , Hu Yuxiang , Xia Weiyi , Zhang Yihan , Zhao Chen , Wu Lianqun 
Published: November 2022

ObjectiveThyroid-associated ophthalmopathy (TAO) is a disfiguring autoimmune disease, which destroys the structure of orbital tissues and even threatens vision. Metabolic reprograming is critical in autoimmune diseases; however, the metabolic basis of TAO remains to be clarified. Our study aimed to reveal the metabolic profile of TAO.MethodsOrbital adipose/connective tissues from eleven TAO patients and twelve control subjects were collected during surgeries and analyzed with liquid chromatograph-mass spectrometer. Orthogonal partial least-squares discrimination analysis (OPLS-DA), variable importance in projection (VIP), heat map, and volcano plot were used to reveal metabolic profile in TAO. Pathway analysis and metabolites-gene analysis were utilized to explore potential metabolic metabolism in TAO.Results3038 metabolites were detected in samples from the TAO patients and the controls. OPLS-DA analysis of the metabolomics results showed two distinguished groups, demonstrating that TAO has a unique metabolome. Univariate tests identified 593 dysregulated metabolites (P &lt; 0.05), including 367 increased metabolites and 226 decreased metabolites. Pathway analysis showed that changed metabolites were enriched in cholesterol metabolism, choline metabolism in cancer, fat digestion and absorption, regulation of lipolysis in adipocytes, and insulin resistance. In addition, metabolites-gene analysis illustrated that cholesterol metabolism was involved in the pathogenesis of TAO. Endoplasmic reticulum stress-related genes (ATF6, PERK, and IRE1α) expressions were higher in TAO orbital tissues than in control orbital tissues verified by western blot. Additionally, the expression level of diacylglycerol acyltransferase 1 (DGAT1), a key metabolic protein for triacylglycerol synthesis, was increased in orbital tissues of TAO detected by qRT-PCR, indicating disrupted cholesterol metabolism in TAO.ConclusionThe present study demonstrated different metabolite profiles and potential metabolic mechanisms in TAO.
Influence of soil management for soybean production under microbial diversity in amazon soils
Authors: Cardenas-Alegria Oscar Victor , Dantas Carlos Willian Dias , Silva Guedes Lobato Elaine Maria , Da Silva Sandro Patroca , Moraes Cássia de Sousa , Cruz Ana Cecília Ribeiro , Ramos Rommel Thiago Jucá , Carneiro Adriana Ribeiro 
Published: November 2022

The tropical Amazon has a unique biodiversity that has been affected by the development of pastures and economically important crops, such as soybeans. In the Amazon soil, the communities of microorganisms are diverse and act in different biogeochemical activities relevant to their adaptation to the environment. The assessment of changes in soil microorganism communities is essential to consider the impact of agribusiness action in one of the wealthiest regions in diversity in the world. Thus, the soil microbial diversity of the Amazon forest, the north region of Brazil, was evaluated regarding the influence of soybean farming with regions with periods of two and 14 years of exploitation, with regions of pasture and forest area, through the metagenomics approach with new generation sequencing technology, in addition, it was considered chemical characteristics such as pH value, organic matter content, macronutrients, micronutrients, and cations. High microbial diversity was identified at all collection sites and, despite this, bacterial, archaeal, and virus communities were very diverse between sites, with higher identification of Enterobacter cloacae and species of Pseudomonas, Pseudoplusia includens, Methanosarcina barkeri in the farmed and pasture, whose microbial diversity is influenced by the presence of cations and the interaction of organic matter with clay. It was evident that there is a change in the communities of native microorganisms for others adapted in the areas that had their vegetal cover eliminated.
Complete genome sequence analysis of a novel alkane-degrading bacterial strain, Acinetobacter vivianii KJ-1, and its diesel degradation ability
Authors: Zhang Yali , Song Fanyong , Wang Jianing , Zhao Qingqing , Zheng Liwen , Wang Zhenjie , Zhang Xinjian , Gao Yongchao , Chen Guanhong , Huang Yujie 
Published: November 2022

With the increasing demand for diesel in various countries, the ecological pollution caused by the improper use, storage, and accidental leakage of diesel needs to be addressed urgently. As an environmentally friendly and cost-effective method, bioremediation generally uses various microorganisms to remove pollutants from the environment. Here, the strain KJ-1, obtained through an enrichment culture using n-dodecane from oil-contaminated soil near a gas station as the substrate, was identified as Acinetobacter vivianii according to its morphology, biochemistry, and molecular biology. The isolate KJ-1 was able to use diesel as a sole carbon source and more than 40% of diesel was degraded after 12 days of incubation with strain KJ-1 in mineral salts medium. The most suitable diesel concentration and nitrogen source concentrations were 4,140 mg/L and 350–700 mg/L, respectively, for diesel degradation and bacterial growth. The optimal initial pH and temperature for strain KJ-1 growth and diesel degradation were 6.5–8.0 and 20–37°C, respectively. To investigate the diesel-degrading mechanisms of this strain, the complete genome was sequenced and annotated. The complete genome consists of one chromosome with a total length of 3,927,757 base pairs and a G + C content of 41.5%. The genes related to the two-component regulatory system and alkane degradation were analyzed. In addition, two putative alkane monooxygenases were analyzed, and the protein sequences were characterized and compared with other AlkBs in Acinetobacter spp. using sequences downloaded from NCBI. The results demonstrated that A. vivianii KJ-1 may be particularly useful for future bioremediation of diesel-polluted soil.