bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leadership for sustainability
Authors: Mathai Wanjira , del Socorro Aguilar Cucurachi Ma. 
Published: July 2022

Fasten our green belts toward a resilient and sustainable future (p.4)
Wanjira MathaiA more resilient future requires urgent actions to establish harmony between human development and nature, especially after the COVID-19 pandemic. Climate change adaptation requires investing in green belts as nature-based solutions, where innovative grassroots action, local and indigenous knowledge, and gender equality are key. Mathai discusses the question, what does it mean to tighten our green belts? Food systems, the protection of the “earth’s lungs,” the reduction of waste, and the restoration of landscapes are mainly addressed. The Green Belt Movement, led by women in Africa, showed how grassroots action scales up and impacts through long-term sustainable solutions. Restoration movements and initiatives worldwide represent a once-in-a-lifetime opportunity to restore landscapes for productivity, fight carbon emissions, and recover the ecosystem services to sustain human lives.Percepciones locales para la restauración ecológica (p.12)
Ma. del Socorro Aguilar CucurachiA partir de las experiencias sobre el Movimiento Cinturones Verdes, presentadas por Wanjira Mathai en el marco de las Kapuscinski Development Lectures (en febrero 2021), destaco la importancia de la di-mensión social en los procesos de restauración y delineo cuatro formas posibles en las que las percepciones locales se vinculan con la restaura-ción ecológica: (1) las percepciones como impulso para la restauración; (2) la restauración ecológica como objeto de percepción; (3) las percepciones sobre la participación local en la restauración ecológica; y (4) la importancia de las sinergias epistémicas, multiactorales y multidimensio nales. La restauración ecológica implica una base científi ca, que considera entre sus principios la dimensión social, con benefi cios signifi cativos para el bienestar humano.
Análise das ações e estratégias de educação em saúde bucal como promoção de saúde no período gestacional: uma revisão integrativa
Authors: Limeira Arthur Barbosa Palmeira , Medrado Filho Nilton Freitas , Almeida Wellington Gabriel Silva de , Soares Samara Carollyne Mafra 
Published: July 2022

Objetivo: analisar por meio das publicações científicas como estão sendo realizadas as ações e estratégias de educação em saúde bucal que se encontram em fase de proposta ou ainda aquelas que já obtiveram resultados sobre o atendimento do pré-natal odontológico com gestantes brasileiras no âmbito do Sistema Único de Saúde. Métodos: Trata-se de uma revisão integrativa da literatura, cujos dados foram coletados a partir de fontes primárias, por meio de levantamento bibliográfico nas bases de dados Biblioteca Virtual em Saúde (BVS), Google Scholar e Scientific Electronic Library Online (SciELO). Foram incluídos estudos originais que apresentavam propostas de ações e estratégias visando a melhoria do conhecimento das gestantes sobre saúde bucal e foram excluídos estudos de metanálise, revisões sistemáticas, revisões da literatura. Resultados: Dentre os 400 achados e após utilização de filtros, leitura de títulos e resumos, utilizaram-se 14 estudos para compor a revisão. Discussão: Os achados demonstraram que as principais estratégias de educação em saúde bucal se concentram em rodas de conversas para desmistificação de medos da consulta com o cirurgião-dentista durante a gestação, palestras e orientações sobre amamentação, escovação e utilização do fio dental. Considerações finais: A análise dos estudos incluídos sobre ações e estratégias de educação em saúde bucal para gestantes brasileiras demonstra que trabalhos vêm sendo desenvolvidos pelos profissionais permeados pelas mudanças do SUS ao longo do tempo. Entretanto, em relação ao acesso às ações de saúde bucal das gestantes, foi visto uma certa dificuldade. Observou-se que as gestantes ainda possuem uma certa insegurança quanto ao atendimento odontológico durante o período gestacional.
Perencanaan Bangunan Pelindung Pantai di Kawasan Pantai Pesaren Belinyu Provinsi Kepulauan Bangka Belitung
Authors: Lestari Atiqoh Dwi , Hisyam Endang Setyawati , Gunawan Indra 
Published: July 2022

Pantai Pesaren merupakan salah satu pantai yang ada di Desa Bintet, Kecamatan Belinyu, Provinsi Kepulauan Bangka Belitung yang berfungsi sebagai kawasan wisata dan pelabuhan perahu bagi para nelayan. Permasalahan yang sering terjadi di Pantai Pesaren yaitu terjadinya abrasi yang menyebabkan kerusakan pada infrastruktur yang telah ada, sehingga rencana perlindungan pantai diperlukan untuk dapat mencegah kerugian lebih lanjut. Tujuan dari penelitian ini yaitu untuk mengetahui pola arus dan sedimen menggunakan bantuan aplikasi pemodelan, serta untuk menentukan dan merencanakan tipe bangunan pelindung pantai yang sesuai dengan kondisi di kawasan Pantai Pesaren. Metode penelitian dilakukan dengan menganalisis hidro-oceanografi berupa pasang surut, gelombang, pemodelan arus dan transpor sedimen menggunakan aplikasi software 2D. Berdasarkan analisis perencanaan, didapatkan penyebab dominan terjadinya abrasi yaitu gelombang besar dari arah utara dan penyebab lainnya yaitu arah arus dan sedimen dominan tegak lurus pantai sehingga untuk tipe dan bentuk dari bangunan pelindung pantai terpilih yaitu breakwater / pemecah gelombang sisi miring dengan tinggi (HT) sebesar 5,2 m, lebar puncak (lp) sebesar 1,5 m, total lebar dasar (b) sebesar 26,7 m, panjang breakwater (ly) sebesar 350 m, lebar lapis lindung (t) sebesar 1 m, jumlah batu per 10 m² (N) sebanyak 86 butir, berat butir batu lapis utama (W) sebesar 0,179 ton, berat butir batu lapis kedua (W/10) sebesar 0,0179 ton, berat butir batu di inti struktur (W/200) sebesar 0,000895 ton dan berat butir kaki pemecah gelombang (W/15) sebesar 0,0119 ton.
Diagnostic performance of cardiac magnetic resonance segmental myocardial strain for detecting microvascular obstruction and late gadolinium enhancement in patients presenting after a ST-elevation myocardial infarction
Authors: Gräni Christoph , Stark Anselm W. , Fischer Kady , Fürholz Monika , Wahl Andreas , Erne Sophie A. , Huber Adrian T. , Guensch Dominik P. , Vollenbroich René , Ruberti Andrea , Dobner Stephan , Heg Dik , Windecker Stephan , Lanz Jonas , Pilgrim Thomas 
Published: July 2022

BackgroundMicrovascular obstruction (MVO) and Late Gadolinium Enhancement (LGE) assessed in cardiac magnetic resonance (CMR) are associated with adverse outcome in patients with ST-elevation myocardial infarction (STEMI). Our aim was to analyze the diagnostic performance of segmental strain for the detection of MVO and LGE.MethodsPatients with anterior STEMI, who underwent additional CMR were enrolled in this sub-study of the CARE-AMI trial. Using CMR feature tracking (FT) segmental circumferential peak strain (SCS) was measured and the diagnostic performance of SCS to discriminate MVO and LGE was assessed in a derivation and validation cohort.ResultsForty-eight STEMI patients (62 ± 12 years old), 39 (81%) males, who underwent CMR (i.e., mean 3.0 ± 1.5 days) after primary percutaneous coronary intervention (PCI) were included. All patients presented with LGE and in 40 (83%) patients, MVO was additionally present. Segments in all patients were visually classified and 146 (19%) segments showed MVO (i.e., LGE+/MVO+), 308 (40%) segments showed LGE and no MVO (i.e., LGE+/MVO–), and 314 (41%) segments showed no LGE (i.e., LGE–). Diagnostic performance of SCS for detecting MVO segments (i.e., LGE+/MVO+ vs. LGE+/MVO–, and LGE–) showed an AUC = 0.764 and SCS cut-off value was –11.2%, resulting in a sensitivity of 78% and a specificity of 67% with a positive predictive value (PPV) of 30% and a negative predictive value (NPV) of 94% when tested in the validation group. For LGE segments (i.e., LGE+/MVO+ and LGE+/MVO– vs. LGE–) AUC = 0.848 and SCS with a cut-off value of –13.8% yielded to a sensitivity of 76%, specificity of 74%, PPV of 81%, and NPV of 70%.ConclusionSegmental strain in STEMI patients was associated with good diagnostic performance for detection of MVO+ segments and very good diagnostic performance of LGE+ segments. Segmental strain may be useful as a potential contrast-free surrogate marker to improve early risk stratification in patients after primary PCI.
Genotype-Specific ECG-Based Risk Stratification Approaches in Patients With Long-QT Syndrome
Authors: Rieder Marina , Kreifels Paul , Stuplich Judith , Ziupa David , Servatius Helge , Nicolai Luisa , Castiglione Alessandro , Zweier Christiane , Asatryan Babken , Odening Katja E. 
Published: July 2022

BackgroundCongenital long-QT syndrome (LQTS) is a major cause of sudden cardiac death (SCD) in young individuals, calling for sophisticated risk assessment. Risk stratification, however, is challenging as the individual arrhythmic risk varies pronouncedly, even in individuals carrying the same variant.Materials and MethodsIn this study, we aimed to assess the association of different electrical parameters with the genotype and the symptoms in patients with LQTS. In addition to the heart-rate corrected QT interval (QTc), markers for regional electrical heterogeneity, such as QT dispersion (QTmax-QTmin in all ECG leads) and delta Tpeak/end (Tpeak/end V5 – Tpeak/end V2), were assessed in the 12-lead ECG at rest and during exercise testing.ResultsQTc at rest was significantly longer in symptomatic than asymptomatic patients with LQT2 (493.4 ms ± 46.5 ms vs. 419.5 ms ± 28.6 ms, p = 0.004), but surprisingly not associated with symptoms in LQT1. In contrast, post-exercise QTc (minute 4 of recovery) was significantly longer in symptomatic than asymptomatic patients with LQT1 (486.5 ms ± 7.0 ms vs. 463.3 ms ± 16.3 ms, p = 0.04), while no such difference was observed in patients with LQT2. Enhanced delta Tpeak/end and QT dispersion were only associated with symptoms in LQT1 (delta Tpeak/end 19.0 ms ± 18.1 ms vs. −4.0 ms ± 4.4 ms, p = 0.02; QT-dispersion: 54.3 ms ± 10.2 ms vs. 31.4 ms ± 10.4 ms, p = 0.01), but not in LQT2. Delta Tpeak/end was particularly discriminative after exercise, where all symptomatic patients with LQT1 had positive and all asymptomatic LQT1 patients had negative values (11.8 ± 7.9 ms vs. −7.5 ± 1.7 ms, p = 0.003).ConclusionDifferent electrical parameters can distinguish between symptomatic and asymptomatic patients in different genetic forms of LQTS. While the classical “QTc at rest” was only associated with symptoms in LQT2, post-exercise QTc helped distinguish between symptomatic and asymptomatic patients with LQT1. Enhanced regional electrical heterogeneity was only associated with symptoms in LQT1, but not in LQT2. Our findings indicate that genotype-specific risk stratification approaches based on electrical parameters could help to optimize risk assessment in LQTS.
The Prevalence of Activities of Daily Living Impairment in Patients With Heart Failure: A Systematic Review and Meta-Analysis
Authors: Lu Jing , Wang Meng , Zhang Yue , Mao Lifen , Chen Xiaoxiao , Yin Rulan , Shi Xiaoqing 
Published: July 2022

ObjectivesThe prevalence of activities of daily living (ADL) in patients with heart failure (HF) reported in current studies were inconsistent, ranging from 11.1 to 70.5%. The purpose of this study is to quantify the prevalence of ADL impairment in HF patients.MethodsPubMed, Embase, Cochrane, CINAHL, CNKI, SinoMed, VIP, and Wanfang databases were systematically searched for relevant studies (up to March 2, 2022). Cross-sectional, case-control, or cohort studies with detailed descriptions of overall ADL impairment in HF were included. Stata 16.0 was used for statistical analysis. Fixed-effect or random-effect model was adopted according to heterogeneity which was evaluated by Cochran’s Q and I2 values. Sensitivity analysis, subgroup analysis, and meta-regression were performed to investigate the sources of heterogeneity.ResultsA total of 12 studies with 15,795 HF patients were included in the meta-analysis, and the pooled prevalence of ADL impairment in patients with HF was 38.8% (95%CI: 28.2–49.3%; I2 = 99.5%, P &lt; 0.001). No possible sources of heterogeneity were found in subgroup analysis and meta-regression. Funnel plots and Egger’s test showed no publication bias (P = 0.595).ConclusionThe prevalence of ADL impairment is relatively high in HF patients. Differences in the prevalence of ADL impairment in patients with HF may be influenced by country, region, and assessment time. We suggest that more researchers could focus on the changes of ADL impairment in HF patients during different disease periods in different regions and countries.
Abdominal Aortic Aneurysm: Can the Anaconda™ Custom-Made Device Deliver? An International Perspective
Authors: Jubouri Matti , Surkhi Abedalaziz O. , Tan Sven Z. C. P. , Bailey Damian M. , Williams Ian M. , Bashir Mohamad 
Published: July 2022

IntroductionSince the introduction of endovascular aortic repair (EVAR), it has demonstrated excellent clinical outcomes and has replaced open surgical repair (OSR) in the treatment of abdominal aortic aneurysms (AAA). AAA is a life-threatening abnormal dilation of the abdominal aorta to 1.5 times its normal diameter. Several commercial EVAR devices exist on the global market, with the Terumo Aortic Fenestrated Anaconda™ graft showing superiority. In this study, we sought to provide an international perspective using multicenter-multinational data on the Anaconda™ device characteristics, design, and delivery, and discuss relevant literature.Materials and MethodsThis study represents a cross-sectional international analysis of custom-made fenestrated Anaconda™ device. Ethical and legal approval for data collection was obtained from each of the local authorities. For the statistical analysis, SPSS 28 for Windows and R were utilized. Pearson’s chi-square analysis was used to assess differences in cumulative distribution frequencies between select variables. Statistical significance for all two-tailed tests was set at p &lt; 0.05.ResultsA total of 5,030 Anaconda™ devices were implanted during the 9-year study period in 27 countries spanning 6 continents. The predominant device category was bifurcate (83.6%), whereas the most common proximal ring stent configuration being standard (64.5%). All devices were delivered within 8 weeks of diagnosis, with most being implanted within 6–8 weeks (55.4%). The Anaconda™ was indicated in the 3,891 (77.4%) patients due to competitor rejection/inability to treat unsuitable/complex aortic anatomy. In the remaining 1,139 (22.6%) patients, it was utilized based on surgeon preference. Almost all devices (95%) were delivered along with a prototype. Of the total 5,030 Anaconda™ devices, 438 (8.7%) used 0–1 fenestrations, 2,349 (46.7%) used 2–3, while 2,243 (44.6%) utilized 4, 5, or 6 fenestrations.DiscussionThe Terumo Aortic Fenestrated Anaconda™ device features a highly unique and innovative design that enables it to treat highly complex aortic anatomy while achieving excellent results. The Anaconda™’s custom-made approach allows it to be tailored to individual patient anatomy, in addition to the device prototype provided by Terumo Aortic optimize clinical outcomes. Finally, the fenestrated Anaconda™ is a highly versatile device offering a wide range of device categories, configurations, and sizes.
Diagnostic Performance of Sex-Specific Modified Metabolite Patterns in Urine for Screening of Prediabetes
Authors: Li Zaifang , Zhang Yanhui , Hoene Miriam , Fritsche Louise , Zheng Sijia , Birkenfeld Andreas , Fritsche Andreas , Peter Andreas , Liu Xinyu , Zhao Xinjie , Zhou Lina , Luo Ping , Weigert Cora , Lin Xiaohui , Xu Guowang , Lehmann Rainer 
Published: July 2022

Aims/HypothesisLarge-scale prediabetes screening is still a challenge since fasting blood glucose and HbA1c as the long-standing, recommended analytes have only moderate diagnostic sensitivity, and the practicability of the oral glucose tolerance test for population-based strategies is limited. To tackle this issue and to identify reliable diagnostic patterns, we developed an innovative metabolomics-based strategy deviating from common concepts by employing urine instead of blood samples, searching for sex-specific biomarkers, and focusing on modified metabolites.MethodsNon-targeted, modification group-assisted metabolomics by liquid chromatography–mass spectrometry (LC-MS) was applied to second morning urine samples of 340 individuals from a prediabetes cohort. Normal (n = 208) and impaired glucose-tolerant (IGT; n = 132) individuals, matched for age and BMI, were randomly divided in discovery and validation cohorts. ReliefF, a feature selection algorithm, was used to extract sex-specific diagnostic patterns of modified metabolites for the detection of IGT. The diagnostic performance was compared with conventional screening parameters fasting plasma glucose (FPG), HbA1c, and fasting insulin.ResultsFemale- and male-specific diagnostic patterns were identified in urine. Only three biomarkers were identical in both. The patterns showed better AUC and diagnostic sensitivity for prediabetes screening of IGT than FPG, HbA1c, insulin, or a combination of FPG and HbA1c. The AUC of the male-specific pattern in the validation cohort was 0.889 with a diagnostic sensitivity of 92.6% and increased to an AUC of 0.977 in combination with HbA1c. In comparison, the AUCs of FPG, HbA1c, and insulin alone reached 0.573, 0.668, and 0.571, respectively. Validation of the diagnostic pattern of female subjects showed an AUC of 0.722, which still exceeded the AUCs of FPG, HbA1c, and insulin (0.595, 0.604, and 0.634, respectively). Modified metabolites in the urinary patterns include advanced glycation end products (pentosidine-glucuronide and glutamyl-lysine-sulfate) and microbiota-associated compounds (indoxyl sulfate and dihydroxyphenyl-gamma-valerolactone-glucuronide).Conclusions/InterpretationOur results demonstrate that the sex-specific search for diagnostic metabolite biomarkers can be superior to common metabolomics strategies. The diagnostic performance for IGT detection was significantly better than routinely applied blood parameters. Together with recently developed fully automatic LC-MS systems, this opens up future perspectives for the application of sex-specific diagnostic patterns for prediabetes screening in urine.
Influence of sperm DNA fragmentation on the clinical outcome of in vitro fertilization-embryo transfer (IVF-ET)
Authors: Zhu Chunhui , Chen Fang , Zhang Shengmin , She Hong , Ju Yun , Wen Xidong , Yang Chunxia , Sun Yan , Dong Naijun , Xue Tongmin , Liu Kaifeng , Li Feng , Cui Hengmi 
Published: July 2022

PurposeTo evaluate the effect of elevated sperm DNA fragmentation index (DFI) on fresh and frozen embryo transfer cycles.MethodsA retrospective study was performed with 549 fresh embryo transfer cycles and 1340 frozen embryo transfer cycles after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) from 2016 to 2021.ResultsThe statistical results of 549 fresh embryo transfer cycles showed that the delivery rate in the normal sperm DFI group (43.9% vs. 27.1%, P = 0.014) was significantly higher than that in the abnormal sperm DFI group, and there were no significant differences in the biochemical pregnancy rate (59.0% vs. 50.8%, P = 0.232), clinical pregnancy rate (53.1% vs. 40.7%, P = 0.072), or miscarriage rate (17.3% vs. 33.3%, P = 0.098) between the two groups. The results of 1340 frozen embryo transfer cycles showed that the biochemical pregnancy rate (57.9% vs. 45.6%, P = 0.006) and clinical pregnancy rate (50.3% vs. 40.7%, P = 0.027) in the normal sperm DFI group were significantly higher than those in the abnormal sperm DFI group. The delivery rate (40.9% vs. 33.3%, P = 0.074) and miscarriage rate (18.6% vs. 18.0%, P = 0.919) were not significantly different between the two groups.ConclusionThe increase of sperm DFI significantly reduced the delivery rate of fresh embryo transfer cycles and the biochemical pregnancy rate and clinical pregnancy rate of frozen embryo transfer cycles.
Steroids Therapy in Patients With Severe COVID-19: Association With Decreasing of Pneumonia Fibrotic Tissue Volume
Authors: He Jin-wei , Su Ying , Qiu Ze-song , Wu Jiang-jie , Chen Jun , Luo Zhe , Zhang Yuyao 
Published: July 2022

BackgroundWe use longitudinal chest CT images to explore the effect of steroids therapy in COVID-19 pneumonia which caused pulmonary lesion progression.Materials and MethodsWe retrospectively enrolled 78 patients with severe to critical COVID-19 pneumonia, among which 25 patients (32.1%) who received steroid therapy. Patients were further divided into two groups with severe and significant-severe illness based on clinical symptoms. Serial longitudinal chest CT scans were performed for each patient. Lung tissue was segmented into the five lung lobes and mapped into the five pulmonary tissue type categories based on Hounsfield unit value. The volume changes of normal tissue and pneumonia fibrotic tissue in the entire lung and each five lung lobes were the primary outcomes. In addition, this study calculated the changing percentage of tissue volume relative to baseline value to directly demonstrate the disease progress.ResultsSteroid therapy was associated with the decrease of pneumonia fibrotic tissue (PFT) volume proportion. For example, after four CT cycles of treatment, the volume reduction percentage of PFT in the entire lung was −59.79[±12.4]% for the steroid-treated patients with severe illness, and its p-value was 0.000 compared to that (−27.54[±85.81]%) in non-steroid-treated ones. However, for the patient with a significant-severe illness, PFT reduction in steroid-treated patients was −41.92[±52.26]%, showing a 0.275 p-value compared to −37.18[±76.49]% in non-steroid-treated ones. The PFT evolution analysis in different lung lobes indicated consistent findings as well.ConclusionSteroid therapy showed a positive effect on the COVID-19 recovery, and its effect was related to the disease severity.
APOE Is Associated With Serum Tau Following Uncomplicated Mild Traumatic Brain Injury
Authors: Lippa Sara M. , Lange Rael T. , Dalgard Clifton L. , Soltis Anthony R. , Guedes Vivian A. , Brickell Tracey A. , French Louis M. , Gill Jessica 
Published: July 2022

Background and ObjectivesAPOE e4 has been linked to poor outcome following traumatic brain injury (TBI); however, the mechanisms behind this relationship are unclear. Few studies have investigated the relationship between the APOE genotype and established brain related protein biomarkers following TBI. The purpose of this study was to examine this relationship in service members and veterans (SMVs) following TBI.MethodsParticipants were 209 SMVs [124 uncomplicated mild TBI (mTBI); 85 complicated mild, moderate, severe, or penetrating TBI (mod-sev TBI)] prospectively enrolled in the DVBIC-TBICoE 15-Year Longitudinal TBI Study. APOE genotyping was undertaken using non-fasting blood serum samples. Participants were divided into three groups: APOE e2+, APOE e3/e3, and APOE e4+.ResultsIn participants with mTBI, those with the APOE e2 allele had significantly lower levels of tau than those with APOE e4 (p = 0.005, r = 0.43, medium-large effect size). Those with APOE e3/e3 trended toward having higher tau than those APOE e2+ (p = 0.076, r = 0.20, small-medium effect size) and lower tau than those with APOE e4+ (p = 0.062, r = 0.21, small-medium effect size). There were no significant differences in biomarkers based on APOE in the mod-sev TBI group.DiscussionThis study is the first to demonstrate APOE genotype is related to serum tau levels following a mTBI, extending prior findings to human serum following mTBI. In addition to higher serum tau levels in APOE e4 carriers, lower tau levels were observed in APOE e2 carriers, suggesting a possible protective effect.