bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for skip metastasis in patients with papillary thyroid microcarcinoma
Authors: Wu Xin , Li Binglu , Zheng Chaoji , He Xiaodong 
Published: December 2022

AbstractBackgroundLymph node metastasis (LNM) is prevalent in papillary thyroid microcarcinoma (PTMC) and is essential when determining tumor stage and prognosis. Positive lateral LNM with negative central LNM is defined as skip metastasis. Thyroid carcinoma's risk factors for skip metastasis remain controversial, especially in PTMC. This study aimed to determine the clinical features as well as the risk factors of skip metastasis among patients with PTMC.MethodsWe conducted retrospective research among patients with PTMC who were subjected to treatment at our Hospital between January 2018 and December 2019 by reviewing their medical records. A database containing demographic characteristics, ultrasonography features, blood test outcomes, operation information, pathology details, and follow‐up information was constructed. The link between skip metastasis and clinicopathological features of PTMC was evaluated using univariate as well as multivariate analyses.ResultsOverall, 293 patients diagnosed with PTMC and lateral LNM were included. There were 91 men (31.1%) and 202 women (68.9%). The median age was 38 (31–47) years. Fifty patients were diagnosed with skip metastases. Levels III and II + III were the most prevalent in single‐level and two‐level metastasis, correspondingly. Univariate and multivariate analyses detected two independent factors linked to skip metastasis in PTMC: female sex (odds ratio = 2.609, 95% confidence interval (CI): 1.135–6.000; p = 0.024) and location of the tumor (upper portion) (odds ratio = 2.959, 95% CI: 1.552–5.639; p = 0.001).ConclusionsSkip metastasis is prevalent in thyroid carcinoma. Female sex and tumor location (upper portion) are independently linked to skip metastasis in PTMC. Patients who have these two risk factors should undergo a meticulous preoperative and intraoperative evaluation of lymph node status.
Drug‐coated balloon for the treatment of small vessel disease: 9 months of angiographic results and 12 months of clinical outcomes of the PEPCAD China SVD study
Authors: Qian Juying , Wu Yizhe , Li Chenguang , Yin Jiasheng , Fu Guosheng , Wang Jian'an , He Yong , Ma Genshan , Chen Yundai , Xia Yong , Li Lang , Ji Fusui , Zeng Hesong , Wei Meng , Nie Shaoping , Jin Huigen , He Ben , Chen Yuguo , Liu Fan , Wang Hui , Sun Yingxian , Xu Bo , Ge Junbo ,   the PEPCAD China SVD study
Published: December 2022

AbstractBackgroundWhether the drug‐coated balloons (DCBs)‐alone strategy was superior to plain old balloon angioplasty (POBA) in treating SVD remains unknown.AimsWe aimed to evaluate the efficacy and safety of DCBs for the treatment of coronary de novo small vessel disease (SVD) and provide further evidence for extending the clinical indications of DCBs. (ChiCTR1800014966).MethodsEligible patients were randomized at a 2:1 ratio to receive DCB treatment or POBA in this prospective, multicenter clinical trial. The reference vessel diameter of lesions was visually assessed to be 2.0 to 2.75 mm. The primary endpoint of the study was angiographic in‐segment late luminal loss (LLL) at the 9‐month follow‐up to demonstrate the superiority of DCB treatment to POBA in SVD. The composite clinical endpoints included clinically driven target lesion revascularization (CD‐TLR), target lesion failure (TLF), major adverse cardiac events (MACEs), and thrombosis at the 12‐month follow‐up.ResultsA total of 270 patients were enrolled (181 for DCB, 89 for POBA) at 18 centers in China. The primary endpoint of 9‐month in‐segment LLL in the intention‐to‐treat population was 0.10 ± 0.33 mm with DCB and 0.25 ± 0.38 mm with POBA (p = 0.0027). This difference indicated significant superiority of DCB treatment (95% CI: −0.22, −0.04, psuperiority = 0.0068). The rates of the clinical endpoints—CD‐TLR, TLF, and MACEs—were comparable between groups. No thrombosis events were reported.ConclusionsDCB treatment of de novo SVD was superior to POBA with lower 9‐month in‐segment LLL. The rates of clinical events were comparable between the two devices.
Congenital hyperinsulinism—A case of mild hypoglycemia in an adult, detected by family testing
Authors: Baleanu Felicia , Taujan Georgiana , Rosu Mihaela , Kosmopoulou Olga , Papadopoulou Blerta Ioanna , Boros Emese , Iconaru Laura 
Published: December 2022

AbstractSymptoms of mild hypoglycemia are easily overlooked especially when there are no complaints from the patients, but it could be a warning sign of an underlying genetic disease. Genetic testing for the entire family is a key step in neonatal hypoglycemia workup.
Key signs indicating mesenteric panniculitis
Authors: Yamamoto Koichiro , Honda Hiroyuki , Ogawa Hiroko , Otsuka Fumio 
Published: December 2022

AbstractSince patients with mesenteric panniculitis (MP) present non‐specific symptoms, diagnosing MP is challenging. We describe a 45‐year‐old man who developed MP with radiologic findings of a “fat ring sign” and a “tumoral pseudocapsule sign.” These signs shown in the present case are crucial for a precise diagnosis of MP.
Why only me? A case report of a breast cancer patient with unresolved trauma from a past disaster experience developing a mental disorder
Authors: Kaneda Yudai , Hori Arinobu , Kotera Yasuhiro , Wada Masahiro , Sawano Toyoaki , Kanemoto Yoshiaki , Kurokawa Tomohiro , Tsubokura Masaharu , Tanimoto Tetsuya , Ejiri Tomozo , Kanzaki Norio , Ozaki Akihiko 
Published: December 2022

AbstractLittle is known about how the psychological stress of having experienced a natural disaster affects cancer patients. We experienced a patient who was treated with breast cancer after having been stricken by a typhoon, which resulted in significant psychological damage. Treatment strategies should incorporate patients' mental health appropriately after disasters.
Surgical site infection following orthopedic surgery in a patient with acne: A challenging case
Authors: Dadkhahfar Sahar , Ohadi Laya , Biglari Farsad , Jafari Kafiabadi Meisam 
Published: December 2022

AbstractPropionibacterium acnes is a typical component of the human body's flora and has been implicated as the causative infectious agent following a variety of operations, including device installation. We present a case of a 21‐year‐old male patient with severe global acneiform eruption with a non‐healing limb lesion near the orthopedic surgery incisions.
Lichenoid lesions around the anus: An unusual site of Hailey–Hailey disease
Authors: Hammami Fatma , Sellami Khadija , Chaabouni Rim , Boudaya Sonia , Amouri Meriem , Bahloul Emna , Turki Hamida 
Published: December 2022

AbstractThe anal region is an unusual site of Hailey–Hailey disease. It manifests with lichenoid lesions with crusted erosions around the anus. It should be differentiated from condylomata acuminata, extramammary Paget disease, and bowenoid papulosis.
High‐pressure injection of paint into the hand: A small injury with serious consequences
Authors: Ben Fredj Aymen , Chatbouri Farouk , Rbai Hedi , Farhat Fourat , Daadoucha Abderrahmen 
Published: December 2022

AbstractHigh‐pressure injection injury to the hand is a rare but very serious clinical entity, considered by plastic and hand surgeons as a surgical emergency. Diagnosis of these injuries is frequently delayed due to the initial benign appearance of the wound and the lack of knowledge of the seriousness of this injury.
Keloids on stretch marks: Case of a Cameroonian lady
Authors: Defo Defo , Zoua Julie Carole , Ngangue Engome Alexandra Dominique , Mendouga Menye Coralie Reine , Tounouga Dahlia Noelle , Kouotou Emmanuel Armand 
Published: December 2022

AbstractKeloids are hypertrophic scars that develop as a result of various pathophysiologic mechanisms. We report a case of a 30‐year‐old Cameroonian woman who presented with keloid‐like masses in the abdomen. The onset was postpartum without trauma. After histopathologic confirmation, we concluded a postinflammatory keloid.
Single Electrochemical Impacts of Shewanella oneidensis MR‐1 Bacteria for Living Cells Adsorption onto a Polarized Ultramicroelectrode Surface
Authors: Smida Hassiba , Lefèvre François‐Xavier , Thobie‐Gautier Christine , Boujtita Mohammed , Paquete Catarina M. , Lebègue Estelle 
Published: December 2022

AbstractInvited for this issue's Front Cover is the Electrochemistry group of the CEISAM Laboratory at Nantes University (France). The cover picture illustrates the electrostatic attraction of the negatively‐charged electroactive Shewanella oneidensis bacterium onto the positively‐charged ultramicroelectrode surface polarized at the oxidation potential of ferrocyanide. Read the full text of the Research Article at 10.1002/celc.202200906.
Aufbaukörnungen aus gipshaltigem Mauerwerkbruch – Teil 2: Untersuchungen im Pilotmaßstab
Authors: Müller Anette , Liebezeit Steffen , Palzer Ulrich 
Published: December 2022

AbstractHeterogene Bauabfälle wie Mauerwerkbruch haben Potenzial als Rohstoff für die Herstellung von leichten Gesteinskörnungen, die den Blähtonen oder auch dem Bims ähnlich sind. In dem vorliegenden Beitrag wurde die Eignung von Ausgangsmaterialien mit erheblichen Gipsgehalten im Pilotmaßstab untersucht. Anhand der Ergebnisse konnten erste technologische Aussagen gemacht werden. Danach können energetische Vorteile im Vergleich zu leichten Gesteinskörnungen aus Blähtonen erwartet werden.
Response surface methodology (RMS) modelling to improve n‐dodecane degradation using Debaryomyces hanseniiLAF‐3 in a simulated desalter effluent
Authors: Azimian Leila 
Published: December 2022

AbstractThe effluent from a petroleum desalting unit contains salts, emulsifiers, hydrocarbons (mainly n‐dodecane), and other contaminants. Conventional wastewater treatment cannot be used to treat this salt‐containing effluent; thus, alternative approaches must be explored. In this study, a halo‐tolerant yeast, Debaryomyces hansenii, was investigated for the removal of varying concentrations of n‐dodecane in a simulated desalter effluent (SDE). Then, the removal of n‐dodecane was optimized using response surface methodology (RSM). The effects of pH, salt, temperature, and n‐dodecane concentration were evaluated, and a mathematical model was developed and verified. The results showed that complete removal of n‐dodecane was achieved at 20°C and a salt concentration of 1–5 g L−1. The main factors in COD removal are temperature, n‐dodecane concentration, pH, and the interaction between n‐dodecane and temperature. Salt concentration does not affect COD removal or the growth rate of D. hansenii in a SDE. Applying RSM suggested that interactional effects among the operational variables include temperature, n‐dodecane concentration, and pH on the yeast's removal rate. Overall, it can be concluded that the use of D. hansenii could be a viable solution at a wide range of salt concentrations (1–5 g L−1) for desalter wastewater treatment in petroleum refining.
Catalytic oxidation of nitric oxide over modified carbide slag: Experimental and theoretical studies
Authors: Wang Fang , Sun Lina , Jia Lijuan , Song Xin , Ning Ping 
Published: December 2022

AbstractIn this work, experimental and theoretical methods were used to investigate the catalytic effect of K2O on NO oxidation. Experimental results indicated that K2O was the main active component. It enhanced the removal of NO and decreased the reaction temperature. Theoretical results indicated that the K2O (001)‐O surface was more suitable for the adsorption of NO and O2. Also, NO and O2 on the Ca(OH)2 surface may migrate to the K2O surface for reaction. NO2 was formed via the interaction of (NO)2 and O atoms. The formation of ONNO was the key step for NO oxidation, which was more conducive to the subsequent oxidation of NO.
Electrolyte Engineering for Safer Lithium‐Ion Batteries: A Review
Authors: Cao Chencheng , Zhong Yijun , Shao Zongping 
Published: December 2022

Comprehensive SummaryDespite being widely used in people's daily life, the safety issue of lithium‐ion batteries (LIBs) has become the major barrier for them to be applied in electrical vehicles (EVs) or large‐scale energy storage. Typically, due to the use of liquid electrolytes containing flammable solvents which are easily oxidized by excessive and accumulated heat, the potential thermal runaway is a major safety concern for traditional LIBs. A strategy for a safer electrolyte design is controlling the flammability and volatility of the liquid electrolytes, to effectively prevent thermal runaway, thus avoiding fire or other risks. Through this study, the mechanisms of thermal runaway and the recent progress in electrolyte engineering toward LIBs were summarized, covering the major strategies including adding flame‐retardants, the utilization of ionic liquid electrolytes and solid electrolytes. The characteristics, strengths and weaknesses of different strategies were discussed. New designing directions of safer electrolytes for the LIBs were also provided.
Performance evaluation of investment with DEA models under pure jump processes
Authors: Mirsadeghpour Zoghi Seyedeh Masoumeh , Sanei Masoud , Tohidi Ghasem , Banihashemi Shokoofeh , Modarresi Navideh 
Published: December 2022

SummaryPortfolio optimization is a selection of the best combination of financial assets that maximizes the return and minimizes the risk. As the stock return distributions exhibit skewness, kurtosis, and heavy‐tailedness, for asset performance evaluation through the data envelopment analysis (DEA), we assume that the asset returns follow a pure jump Lévy process. For this purpose, two risk measures are provided as value‐at‐risk (VaR) and conditional VaR (CVaR). To deal with negative values, the range directional measure (RDM) model is utilized in the appropriate Lévy process, and inefficiency measurements are compared. Moreover, the asset price jumps have significant effects on the input and output of DEA models, risk measures, mean returns, and efficiency scores. In this regard, there are two optimization problems integrating DEA based on the variance gamma (VG) Lévy process, in which the input and output are stochastic. One of these two problems is a multi‐objective optimization model that evaluates more reliable efficiency scores than the other models. For this purpose, the VG parameters are estimated through the moments estimation method in order to analyze seven companies listed in the Tehran stock exchange (TSE). Finally, the Kolmogorov–Smirnov goodness‐of‐fit test is conducted. The results indicate that the VG model fits properly and is well suited to assets returns.
Certificate revocation schemes for providing secure QoS in MANETs
Authors: Sahana Devarayapattana Siddalingaiah , Gopala krishnan Chandrasekaran 
Published: December 2022

SummaryDue to crucial exchange issues, security in mobile ad hoc networks (MANETs) is more complicated. It is vital to secure MANET exchanges to ensure the network's services development. In this research, the proposed model focuses on providing trust and certificate‐based Malicious Node detection for mobile adhoc networks and improving certificate revocation based on cluster head. The cluster head is crucial in eliminating falsely accused nodes. The malicious node may be easily discovered and isolated from the network using the trusted value. If the trust value falls below the trust threshold value in a trust management, the node is identified as malicious, the certificate is canceled, and the node is isolated from the network. The TSQRS protocol's integration with the CRS scheme was the main emphasis of the suggested model. The proposed model also creates more stable clusters with the help of Trust manager. When compared to other current protocols and methodologies, the findings produced by the suggested approach for the TSQRS‐CRS scheme improve performance and stability in the QoS of MANETs. Finally, certain parameters were used to run the simulation, which resulted in an improved Packet Delivery Ratio, Routing Overhead, and reduced Delay.
Enhanced routing using recurrent neural networks in software defined‐data center network
Authors: Modi Tejas M. , Swain Pravati 
Published: December 2022

SummarySoftware Defined‐DCN (SD‐DCN) is a layered topology with logically centralized control which provides intelligence thro‐ugh programmability. The controller in SD‐DCN provides different network management skills by decoupling of control plane and data plane. However, the controller applies traditional artificial intelligence approaches and neural network approaches for routing strategies in recent systems. To manage dynamic changes in the network, deep learning approaches provide deep analysis and prediction to enhance the existing network performance. In convolutional neural network (CNN) deep learning model, the learning process executes based on present traffic data and forgets the inputs for the future learning phase. To overcome CNN limitation, in this article, different recurrent neural network (RNN) deep learning models are used to improve the routing computation for SD‐DCN topology. The long short‐term memory (LSTM)‐ RNN and bi‐directional long short‐term memory (BiLSTM)‐RNN deep learning models provide forget gate to analyze periodic network traffic datasets and improve routing by delivering dynamic and intelligent routing paths in the network. The proposed system is implemented in a simulation scenario, and the proposed work improves the network performance in hot‐spot traffic as compared to the existing mechanisms. Moreover, error analysis of different deep learning models is presented in the evaluation results.
Assessing an active distracting technique during primary mandibular molar pulpotomy (randomized controlled trial)
Authors: Alsibai Ekram , Bshara Nada , Alzoubi Hasan , Alsabek Laith 
Published: December 2022

AbstractObjectivesThis study aims to evaluate the effectiveness of two different distraction techniques (Audio Video Distraction/Video Game Distraction) in the management of anxious pediatric patients during dental treatment.Materials and MethodsOne hundred and five children were randomly divided into three groups; Group A: active distraction using video games on a tablet device and wireless joystick (VG). Group B: passive distraction using video on tablet, and wireless headphones (AV). Group C (Control group): basic behavior guidance technique Tell Show Do was used (C). The children were selected from the department of pediatric dentistry at the Faculty of Dentistry, Damascus University, who required pulpotomy in primary mandibular molars. All children were assessed by: Simplified Wong‐Baker FACES for pain scale (self‐report), and “HOUPT” Behavior Rating Scale for Overall Behavior (non‐self‐report), at the end of treatment.ResultsOne hundred and five children completed the study (57 boys and 48 girls) aged between 6 and 10 years (mean age of 7.4 years). The active distraction (VG) group was superior to the passive distraction (AV) group and the control group (C) on the pain scale with statistically significant differences as appeared in Simplified Wong‐Baker Scale (p = .000), The active distraction (VG) group was superior to the control group (C) in overall behavior as appeared in HOUPT scale (p = .041), but it was no statistically significant differences between (VG) group and (AV) group in overall behavior (p = .605). With the use of Bluetooth technology and wireless devices, the workspace was comfortable for the dentist and did not interfere with the movement of his hands.ConclusionPositive distraction with video games by wireless joystick displayed on the portable tablet on the dental chair was the best technique for reducing dental anxiety and reported pain in school children (6‐10 years) and was better than negative distraction by video cartoons on the tablet device.
Mutations in a set of ancient matrisomal glycoprotein genes across neoplasia predispose to disruption of morphogenetic transduction
Authors: Langthasa Jimpi , Mishra Satyarthi , U Monica , Kalal Ronak , Bhat Ramray 
Published: December 2022

AbstractMisexpression and remodeling of the extracellular matrix is a canonical hallmark of cancer, although the extent of cancer‐associated aberrations in the genes coding for extracellular matrix (ECM) proteins and the consequences thereof are not well understood. In this study, we examined the alterations in core matrisomal genes across a set of nine cancers. These genes, especially the ones encoding for ECM glycoproteins (GP), were observed to be more susceptible to mutations than copy number variations across cancers. We classified the glycoprotein genes based on the ubiquity of their mutations across the nine cancer groups and estimated their evolutionary age using phylostratigraphy. To our surprise, the ECM glycoprotein genes commonly mutated across all cancers were predominantly unicellular in origin, whereas those commonly showing mutations in specific cancers evolved mostly during and after the unicellular‐multicellular transition. Pathway annotation for biological interactions revealed that the most pervasively mutated glycoprotein set regulated a larger set of inter‐protein interactions and constituted more cohesive interaction networks relative to the cancer‐specific mutated set. In addition, ontological prediction revealed the pervasively mutated set to be strongly enriched for basement membrane (BM) dynamics. Our results suggest that ancient unicellular‐origin ECM GP were canalized into playing critical tissue morphogenetic roles, and when disrupted through matrisomal gene mutations, associated with neoplastic transformation of a wide set of human tissues.
Progressive accumulation of cytoplasmic aggregates in PRPF31 retinal pigment epithelium cells interferes with cell survival
Authors: Georgiou Maria , Atkinson Robert , Mozaffari‐Jovin Sina , Lako Majlinda 
Published: December 2022

AbstractRetinitis Pigmentosa (RP) is a common form of inherited degenerative disease that often leads to blindness. About 10% autosomal dominant RP cases have been associated with mutations in PRPF31 gene, which is involved in pre‐mRNA splicing. This commentary summarises the key findings of our recent publication ‘Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells’ in the context of large cytoplasmic aggregates which accumulate progressive with time and impair cell function and survival. Understanding the pathomechanism of PRPF31‐RP provides invaluable information that can be used to understand other PRPF‐RPs, and help to design effective and appropriate therapeutic strategies for the treatment of RP patients with PRPF31 mutations.