bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Related Effects on the Spectrum of Cerebral Visual Impairment in Children With Cerebral Palsy
Authors: Galli Jessica , Loi Erika , Molinaro Anna , Calza Stefano , Franzoni Alessandra , Micheletti Serena , Rossi Andrea , Semeraro Francesco , Fazzi Elisa ,   CP Collaborative Group
Published: March 2022

BackgroundCerebral Visual Impairment (CVI) is a very common finding in children affected by Cerebral Palsy (CP). In this paper we studied the characteristics of CVI of a large group of children with CP and CVI, describing their neurovisual profiles according to three different age subgroups (subgroup 1: infants 6 months–2 years; subgroup 2: pre-school age 3–5 years; subgroup 3: school age ≥ 6 years).MethodsWe enrolled 180 subjects (104 males, mean age 66 ± 42.6 months; range 6–192 months) with CP and CVI for the study. We carried out a demographic and clinical data collection, neurological examination, developmental or cognitive assessment, and a video-recorded visual function assessment including an evaluation of ophthalmological characteristics, oculomotor functions, and basic visual functions. In school-aged children, we also performed an evaluation of their cognitive-visual profiles.ResultsThere were signs of CVI in all the three subgroups. Subgroup 1 (62 children) and subgroup 2 (50 children) were different for fixation (p = 0.02), visual acuity (p = 0.03) and contrast sensitivity (p &lt; 0.01), being more frequently impaired in younger children. Comparing subgroup 2 with subgroup 3 (68 children), the older children presented more frequently myopia (p = 0.02) while the younger ones esotropia (p = 0.02) and alteration in smooth pursuit (p = 0.03) and saccades (p &lt; 0.01). Furthermore, fixation, smooth pursuit, visual acuity, contrast sensitivity and visual filed (p &lt; 0.01) were more frequently impaired in younger children (subgroup 1) compared to the older ones. Multiple correspondence analysis (MCA) confirmed the different neurovisual profiles according to age: younger children with CP showed more signs of CVI compared to the older ones. 34 out of 68 children belonging to subgroup 3 underwent the cognitive visual evaluation; an impairment of cognitive visual skills was detected in 21 subjects.ConclusionYounger children with CP showed more signs of CVI compared to the older ones, likely for the physiological maturation of visual system and mechanisms of neuroplasticity. In this direction, we suggest an early neurovisual evaluation to detect any weak visual functions.
Improvement in Anthropometric Measurements of Malnourished Children by Means of Complementary Food and Nutritional Education in Fars Province, Iran: A Community-Based Intervention
Authors: Shenavar Razieh , Sajjadi Seyedeh Forough , Farmani Azam , Zarmehrparirouy Mina , Azadbakht Leila 
Published: March 2022

BackgroundChildhood malnutrition could have adverse impacts on the growth of child and eventually on fertility and general economic growth, and still, this issue remains a worldwide priority and a concern. This study aimed to evaluate the effectiveness of the national nutritional interventions program on the improvement and nutritional status of malnourished children children aged 6–59 months.MethodsThis community-based intervention study was conducted with 1288 acute and moderately malnourished children aged 6–59 months referred to health centers. Children received combined nutritional education and counseling with the provision of affordable complementary food for 10 months. Anthropometric measurements were assessed monthly according to the standard protocols.ResultsOur results showed the reduction in the risk of malnutrition among children after nutritional interventions for weight-for-height (WHZ) (P &lt; 0.001), height-for-age (HAZ) (P &lt; 0.001), and weight-for-age (WAZ) (P = 0.008). Total malnourished children indicated improvement in HAZ (&lt;-3 SD: OR = 1.10, P = 0.026), WAZ (&lt;-2SD: OR = 1.21, P &lt; 0.001; &lt;-3SD: OR = 1.60, P &lt; 0.001), and WHZ (&lt;-3SD: OR = 1.10, P = 0.030). Controlling potential confounders (socioeconomic status, childrens' birth supine length, and weight) showed a significant amelioration in HAZ (&lt;-2 SD: OR = 6.20, P = 0.020; &lt;-3 SD: OR = 9, P = 0.003) and WAZ (&lt;-2 SD: OR = 5.85, P = 0.010; &lt;-3 SD: OR = 7.50, P = 0.004). In urban areas, significant amelioration was observed in HAZ (&lt;-3 SD: OR = 1.22, P = 0.010) and WAZ (&lt;-2 SD: OR = 1.24, P = 0.003; &lt;-3 SD: OR = 1.64, P &lt; 0.001). In rural, considerable amelioration was observed in WAZ (&lt;-2 SD: OR = 1.20, P = 0.010; &lt;-3 SD: OR = 1.50, P &lt; 0.001) and WHZ (&lt;-3 SD: OR = 1.20, P = 0.020).ConclusionNutritional training and counseling as well as complementary food intervention among the malnourished children significantly improved the nutritional status of children. So community-based intervention is recommended to reduce the malnutrition among children.
Targeting the lncRNA DUXAP8/miR-29a/PIK3CA Network Restores Doxorubicin Chemosensitivity via PI3K-AKT-mTOR Signaling and Synergizes With Inotuzumab Ozogamicin in Chemotherapy-Resistant B-Cell Acute Lymphoblastic Leukemia
Authors: Zhang Li , Zhou Shixia , Zhou Tiejun , Li Xiaoming , Tang Junling 
Published: March 2022

PurposeThis study aimed to determine the expression profiles of long non-coding RNA (lncRNA), microRNA (miRNA), and mRNA in chemotherapy-resistant B-cell acute lymphoblastic leukemia (B-ALL).MethodsLncRNA, miRNA, and mRNA profiles were assessed by RNA-seq in diagnostic bone marrow samples from 6 chemotherapy-resistant and 6 chemotherapy-sensitive B-ALL patients. The lncRNA DUXAP8/miR-29a/PIK3CA signaling network was identified as the most dysregulated in chemoresistant patient samples, and its effect on cellular phenotypes, PI3K-AKT-mTOR signaling, and chemosensitivity of doxorubicin (Dox)-resistant Nalm-6 (N6/ADR), and Dox-resistant 697 (697/ADR) cells were assessed. Furthermore, its synergy with inotuzumab ozogamicin treatment was investigated.Results1,338 lncRNAs, 75 miRNAs, and 1620 mRNAs were found to be dysregulated in chemotherapy-resistant B-ALL in comparison to chemotherapy-sensitive B-ALL patient samples. Through bioinformatics analyses and RT-qPCR validation, the lncRNA DUXAP8/miR-29a/PIK3CA network and PI3K-AKT-mTOR signaling were identified as significantly associated with B-ALL chemotherapy resistance. In N6/ADR and 697/ADR cells, LncRNA DUXAP8 overexpression and PIK3CA overexpression induced proliferation and inhibited apoptosis, and their respective knockdowns inhibited proliferation, facilitated apoptosis, and restored Dox chemosensitivity. MiR-29a was shown to affect the lncRNA DUXAP8/PIK3CA network, and luciferase reporter gene assay showed direct binding between lncRNA DUXAP8 and miR-29a, as well as between miR-29a and PIK3CA. Targeting lncRNA DUXAP8/miR-29a/PIK3CA network synergized with inotuzumab ozogamicin’s effect on N6/ADR and 697/ADR cells.ConclusionTargeting the lncRNA DUXAP8/miR-29a/PIK3CA network not only induced an apoptotic effect on Dox-resistant B-ALL and restored Dox chemosensitivity via PI3K-AKT-mTOR signaling but also showed synergism with inotuzumab ozogamicin treatment.
Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis
Authors: Huang Hua , Shi Zijian , Li Yongwen , Zhu Guangsheng , Chen Chen , Zhang Zihe , Shi Ruifeng , Su Lianchun , Cao Peijun , Pan Zhenhua , Zhang Hongbing , Liu Minghui , Liu Hongyu , Chen Jun 
Published: March 2022

BackgroundPyroptosis is a new type of programmed cell death, accompanied by an intense inflammatory response. Previous studies have shown that pyroptosis can modify long-chain non-coding RNA (lncRNA), thereby affecting the occurrence and progression of tumors. However, the underlying role of pyroptosis-related lncRNA in lung adenocarcinoma (LUAD) remains to be elucidated. Therefore, the purpose of our study was to evaluate the prognostic value of pyrolysis-related lncRNA in patients with LUAD.MethodsA total of 454 LUAD samples were downloaded from The Cancer Genome Atlas (TCGA) database. Pearson’s correlation coefficient was used to identify the pyroptosis-related lncRNAs. Unsupervised consensus clustering was used to identify the various LUAD molecular subtypes. A least absolute shrinkage and selection operator (LASSO) analysis was conducted to construct a prognostic signature.ResultsAn 11-lncRNA prognostic signature out of 19 identified pyroptosis-related prognostic lncRNAs was constructed. The patients with LUAD were divided into low-risk and high-risk groups. Patients in the high-risk group had higher score values and mortality. The immune score, stromal score, and estimate score were lower in the high-risk group. The risk score was an independent predictor for OS in multivariate Cox regression analyses (HR &gt; 1, p &lt; 0.01). BTLA, PD-1, PD-L1, CTLA, and CD47 were lower expressed in the high-risk group.ConclusionsOur study identified an 11-pyroptosis-related lncRNA signature. These findings could further clarify the role of pyroptosis in LUAD and guide the prognosis and individualized treatment of patients.
Effects of 6-Week Traditional and Functional Resistance Training on Arterial Stiffness and Muscular Strength in Healthy Young Men
Authors: Zuo Chongwen , Li Qing , Zhang Li , Bo Shumin 
Published: March 2022

BackgroundThe present study investigated the effects of traditional resistance training (TRT) and functional resistance training (FRT) on arterial stiffness and muscular strength in healthy young men.MethodsThis randomized controlled trial included 29 untrained healthy young men aged 18–29 years who were randomly divided into two groups, namely, TRT group (n = 15) and FRT group (n = 14). All participants underwent numerous tests, such as those for body composition, cardio-ankle vascular index, blood pressure, heart rate, and maximal strength before and after the 6-week training program. The exercise training comprised whole-body strength training exercises 3 days a week for 6 weeks. The total training volume and number of sets (4–5 sets) were kept constantly similar in each group. The TRT group completed 4–5 sets of 8–12 repetitions [70% of 1 repetition maximum (1RM)], whereas the FRT group completed 4–5 sets of 15–22 repetitions (40% 1RM).ResultsThe TRT and FRT groups exhibited equally significantly increased maximal strength (within group: both p &lt; 0.01). Furthermore, the independent t-test showed that the differences between the two groups in terms of changes in maximal strength were no significant (between group: both p &gt; 0.05). Additionally, significant main effects of time (pre vs. post) were observed for the left and right cardio-ankle vascular indices (p &lt; 0.05); however, no significant difference were observed between the groups. For body compositions outcome measures, no significant differences between groups were observed.ConclusionSix weeks of FRT and TRT exhibit no difference in terms of effects on arterial stiffness and muscular strength.
Does Gender Moderate the Relationship Between Chronic Pain and Substance Use Disorder? Insights From a National Canadian Population Survey
Authors: Su Yingying , Meng Xiangfei , D'Arcy Carl 
Published: March 2022

BackgroundThough it has been shown that men have a higher lifetime prevalence of substance use disorder and a lower prevalence of chronic pain than women, there is little research to date focusing on gender differences in the relationship between chronic pain and substance use disorder. This study examined whether gender moderates the relationship of chronic pain and substance use disorder. We also sought to examine the gender differences in the associations between specific pain types—arthritis, migraine, and back pain, and substance use disorder.MethodsThe data were drawn from the 2012 Canadian Community Health Survey-Mental Health (CCHS-MH 2012) with individuals aged 20 years and older living in the 10 Canadian provinces (N = 23,089). A two-level logistic mixed effects model was used to account for provincial differences.ResultsOur findings indicated gender moderated the association between arthritis as well as migraine, and substance use disorder. However, no moderation effect of gender on the relationship between back pain and substance use disorder was found. Specifically, the strength of the association between arthritis and substance use disorder was stronger among men (ORinteraction = 0.62, 95% CI: 0.53 to 0.73), whereas the strength of the association between migraine and substance use disorder was stronger among women (ORinteraction = 1.45, 95% CI: 1.18 to 1.79). In addition, geographical location was found to explain a small proportion (2.3%-2.4%) of the overall variance in SUD.ConclusionsThe results suggest that gender moderated the relations between arthritis as well as migraine, and substance use disorder, respectively. Treatment programs for pain and substance misuse might benefit from an approach tailored to gender differences.
Factors Associated With Experiences of Fear, Anxiety, Depression, and Changes in Sleep Pattern During the COVID-19 Pandemic Among Adults in Nigeria: A Cross-Sectional Study
Authors: Folayan Morenike Oluwatoyin , Ibigbami Olanrewaju , Brown Brandon , El Tantawi Maha , Aly Nourhan M. , Ezechi Oliver C. , Abeldaño Giuliana Florencia , Ara Eshrat , Ayanore Martin Amogre , Ellakany Passent , Gaffar Balgis , Al-Khanati Nuraldeen Maher , Idigbe Ifeoma , Jafer Mohammed , Khan Abeedha Tu-Allah , Khalid Zumama , Lawal Folake Barakat , Lusher Joanne , Nzimande Ntombifuthi P. , Popoola Bamidele Olubukola , Quadri Mir Faeq Ali , Roque Mark , Al-Tammemi Ala'a B. , Yousaf Muhammad Abrar , Virtanen Jorma I. , Zuñiga Roberto Ariel Abeldaño , Ndembi Nicaise , Nkengasong John N. , Nguyen Annie Lu 
Published: March 2022

BackgroundMultiple facets of the pandemic can be a source of fear, depression, anxiety and can cause changes in sleep patterns. The aim of this study was to identify health profiles and the COVID-19 pandemic related factors associated with fear, depression, anxiety and changes in sleep pattern in adults in Nigeria.MethodsThe data for this analysis was extracted from a cross-sectional online survey that collected information about mental health and well-ness from a convenience sample of adults 18 years and above resident in Nigeria from July to December 2020. Study participants were asked to complete an anonymous, closed-ended online questionnaire that solicited information on sociodemographic profile, health profiles (high, moderate and low COVID-19 infection risk profile) including HIV status, COVID-19 status, and self-reported experiences of fear, anxiety, depression and changes in sleep patterns.ResultsIn total, 4,439 participants with mean age of 38.3 (±11.6) years responded to the survey. Factors associated with higher odds of having COVID-19 related fear were health risk (p &lt; 0.05); living with HIV (AOR: 3.88; 95% CI: 3.22–4.69); having COVID-19 symptoms but not tested (AOR: 1.61; 95% CI: 1.30–1.99); having a friend who tested positive to COVID-19 (AOR: 1.28; 95% CI: 1.07–1.53) and knowing someone who died from COVID-19 (AOR: 1.43; 95% CI: 1.24–1.65). The odds of feeling anxious was significantly higher for those with moderate or low health risk profile (p &lt; 0.05); living with HIV (AOR: 1.64; 95% CI: 1.32–2.04); had a friend who tested positive for COVID-19 (AOR: 1.35; 95% CI: 1.08–1.68) or knew someone who died from COVID-19 (AOR: 1.53; 95% CI: 1.28–1.84). The odds of feeling depressed was significantly higher for those with health risk profile (p &lt; 0.05); living with HIV (AOR: 2.49; 95% CI: 1.89–3.28); and respondents who had COVID-19 symptoms but had not taken a test (AOR: 1.41; 95% CI: 1.02–1.94). Factors associated with higher odds of having sleep pattern changes were having moderate and low health risk profiles (p &lt; 0.05).ConclusionThe study findings suggest that the pandemic may cause fear, anxiety, depression and changes in sleep patterns differently for people with different health profile, HIV status and COVID-19 status.
Organic Molecules in Interstellar Space: Latest Advances
Authors: Guélin Michel , Cernicharo Jose 
Published: March 2022

Although first considered as too diluted for the formation of moleculesin-situand too harsh an environment for their survival, the interstellar medium has turned out to host a rich palette of molecular species: to date, 256 species, not counting isotopologues, have been identified. The last decade, and more particularly the last 2 years, have seen an explosion of new detections, including those of a number of complex organic species, which may be dubbed as prebiotic. Organic molecules have been discovered not just in interstellar clouds from the Solar neighbourhood, but also throughout the Milky-Way, as well as in nearby galaxies, or some of the most distant quasars. These discoveries were made possible by the completion of large sub-millimetre and radio facilities. Equipped with new generation receivers, those instruments have provided the orders of magnitude leap in sensitivity required to detect the vanishingly weak rotational lines that allowed the molecule identifications. Last 2 years, 30 prebiotic molecules have been detected in TMC-1, a dust-enshrouded gaseous cloud located at 400 light-years from the Sun in the Taurus constellation. Ten new molecular species, have been identified in the arm of a spiral galaxy seven billion light-yr distant, and 12 molecular species observed in a quasar at 11 billion light-yr. We present the latest spectral observations of this outlying quasar and discuss the implications of those detections in these 3 archetypal sources. The basic ingredients involved in the Miller-Urey experiment and related experiments (H2, H2O, CH4, NH3, CO, H2S, … ) appeared early after the formation of the first galaxies and are widespread throughout the Universe. The chemical composition of the gas in distant galaxies seems not much different from that in the nearby interstellar clouds. It presumably comprises, like for TMC-1, aromatic rings and complex organic molecules putative precursors of the RNA nucleobases, except the lines of such complex species are too weak to be detected that far.
Prototipe Sistem Kontrol Pemadam Kebakaran Pada Rumah Berbasis Arduino Uno dan ESP8266
Authors: Indra Dolly , Alwi Erick Irawadi , Mubarak Muhammad Al 
Published: March 2022

Kebakaran merupakan salah satu kejadian yang mengganggu kenyamanan pemilik rumah. Ketika terjadi kebakaran tidak ada peringatan dini kepada pemilik rumah yang bersangkutan. Dalam penanganannya juga sering kita temui pihak pemadam kebakaran sendiri kesulitan untuk memadamkan api. Metode penelitian yang digunakan adalah penelitian eksperimen dengan melakukan uji coba pada alat untuk memadamkan kebakaran rumah dengan output yang diberikan berupa nyala api dan asap menggunakan modul sensor api dan sensor MQ7. Hasil pengujian pada sensor api didapatkan jarak maksimal mendeteksi nyala api sebesar 120 cm. Sensor MQ7 mendeteksi asap ketika kadar asap melebihi 100 PPM. Sensor DHT22 dapat membaca suhu ruangan dengan nilai akurasi 97,1%. Tingkat keberhasilan sistem ketika bekerja pada ruang tamu sebesar 100%, kamar 1 sebesar 100%, kamar 2 sebesar 100% dan kamar mandi 100%. Tingkat persentase rata-rata keberhasilan keseluruhan sistem dalam bekerja sebesar 100%.
Kata Kunci â€“ Arduno uno, kebakaran rumah, Esp8266, sensor api, MQ7, DHT22.
De l'importance du language dans l'enseignement des mathématiques
Authors: Delavault Huguette 
Published: March 2022

Le problème du langage dans l'enseignement des mathématiques est envisagé sous deux aspects :
1) L'interprétation en langue courante d'un résultat exprimé symboliquement et la lecture d'un texte mathématique qui s'apparente au problème de la traduction mais avec une spécificité due & la précision et la concision du langage mathématique et à l'utilisation d'éléments non verbaux.
2) L'adéquation du langage de l'enseignant et du livre à celui des élèves qui se pose dans tout enseignement mais où l'aide des linguistiques et des professeurs de langue étrangère serait précieuse.
Ces problèmes ne sont que posés et quelques exemples donnés afin de susciter quelques recherches interdisciplinaires.
Trois mythologiques sur Don Juan
Authors: Molho Maurice 
Published: March 2022

Les trois études dont se recompose ce mémoire ont pour objet le mythe de don Juan qui, en dépit de son apparition tardive (XVIIe siècle) n'en satisfait pas moins aux conditions de structure généralement observables dans la tradition mythologique.
Dans une première étude, on examine le mythe dans la version orale recueillie en 1830 à Séville par Prosper Mérimée, sous l'espèce de deux historiettes dont chacune constitue une plaisante subversion, significative à proportion qu'elle s'accuse libératoire du discours mythique traditionnel.
La seconde mythologique est une analyse du mythe tel qu'il se présente pour ta première fois à l'observation dans El Burlador de Sevilla y Corvidedo de Piedra, comédie espagnole d'attribution douteuse et malaisément datable (1620-1630?). La structure mythique est mise à jour, et on tente d'en dégager la signification en vue de la rapporter è un moment spécifique de l'histoire morale de l'Europe.
Enfin la troisième et dernière mythologie qui traite du Festin de pierre et de l'Interprétation qu'il convient de donner dans le discours mythique, de la double invitation prandiale au cours de laquelle la statue du Commandeur entraîne don Juan dans les abîmes de la mort.
Médée, ou le vertige d'un autre monde
Authors: Gally Michèle 
Published: March 2022

Il s'agit ici de se pencher sur les descriptions poétiques et littéraires du personnage légendaire de Médée, prise comme prototype de la magicienne antique. Ce choix tient, d'une part, à la relative «popularité» du nom, d'autre part, au fait que ce mythe illustre la grandeur tragique fondamentale de la magie en tant qu'elle est un rapport aux Dieux, à la Nature et aux Hommes. C'est-à-dire qu'elle n'existe pas en dehors d'un contexte social et mental déterminé. Le mythe ne pouvait que devenir tragédie.
Un premier point montre le passage progressif de Circé à Médée c'est-à-dire d'une notion «divine» à une notion «humaine» de la Magie. Avec l'acquisition d'un statut humain, éclate l'ambivalence du pouvoir magique : magie blanche ou magie noire ?
Enfin, la tragédie est, sous l'apparente lutte de deux amants, le lieu d'affrontement de deux mondes étrangers l'un à l'autre, la Grèce et la Barbarie, dans un combat mortel.
La naissance de la Thermodynamique : Mémoire de Carnot. Réflexions sur la puissance motrice du feu et sur les machines propres à développer cette puissance
Authors: Merle Anne-Marie 
Published: March 2022

El libro de Sadi Carnot : "Reflexions sobre la potencia matriz del fuego y sobre las maquinas aptas para désarroi lar esta potencia" publicado en 1824 marca el nacimiento de la Termodinámica. En dicha obra destinada a establecer una teoría racional de las máquinas de vapor, Carnot sigue un derrotero original, pues es esencialmente intuitivo y axiomático. Despues de un breve resumen historico que justifica el establecimiento de una teoría general, estudia los cambios de calor en una maquina de vapor ideal. Entonces echa las bases del segundo principio de la termodinamica y enuncia el teorema de Carnot. Después de una comprobación experimental de este teorema, estudia sus consecuencias prácticas para la construcción de las máquinas.
Enfin, en las notas póstumas publicadas en 1878, enuncia el primer principio de la Termodinámica.