bluuebunny/crossref_metadata_2025_split huggingface dataset:
AETIOLOGICAL ASPECTS OF THE DEVELOPMENT OF CHRONIC ENDOMETRITIS IN WOMEN WHO PLAN THEIR PREGNANCY
Authors: Taranovska О. 
Published: November 2022

Introduction. In the structure of reproductive loss factors, the role of chronic endometritis is increasing that is obviously due to the persistence of microbial factors. However, the facts confirming the presence of intrauterine microflora and substantiating the appropriateness of antibacterial therapy of the above pathology are quite contradictory and prompt a detailed study of this issue.
The purpose of this study is to investigate the spectrum of the microflora of the lower genital tract and the uterus in women who plan their pregnancy to clarify the role of ascending infection in the development of chronic endometritis.
Subjects and methods. 87 women with histologically confirmed chronic endometritis (main group) and 13 women without this pathology (control group) were examined for the microflora spectrum of the lower genital tract and endometrial samples were studied by bacterioscopic, bacteriological methods and polymerase chain reaction.
Results. Pathological microflora in the cervical canal and vagina in women with chronic endometritis was detected in 75% that is 2.85 times higher than the frequency of the infection detection in women without this pathology (30.7%). The microflora was mainly represented in the form of polymicrobial associations. The spectrum of microorganisms in the cervical canal and vagina mostly coincided with those in the endometrial samples. Most often, Ureaplama spp. (63.2%), chlamydia (31.6%), mycoplasma (26.3%) were detected in the endometrium.
Conclusion. The study has emphasized the key role of ascending infection in the development of chronic endometritis and the need for sanitation of the lower genital tract during its comprehensive treatment.
MORPHOLOGICAL CHARACTERISTICS OF THE TRIGEMINAL NODE OF RATS WHEN CRYOPRESERVED PLACENTA IS INTRODUCED
Authors: Danilov O.D. , Shepitko V.I. , Yakushko O.S. , Stetsuk E.V. , Boruta N.V. 
Published: November 2022

Cryopreserved placenta preparations have a unique composition of biologically active substances, which determines their multifaceted effect. The aim of our study was to investigate the morphological features of the trigeminal node of rats when cryopreserved placenta was injected.
The conducted experimental study showed that a single subcutaneous injection of cryopreserved placenta causes a reaction of the vessels of the microcirculatory bed of the trigeminal node of rats in the first two weeks of observation in the form of an expansion of the diameter of arterioles, capillaries and venules and an increase in blood filling, which indicates the stimulating effect of the components of the fetoplacental complex on the microcirculatory bed. The most pronounced phenomena were observed on the 7th day.
After transplantation of the cryopreserved placenta, the neurocytes of the trigeminal node had a large, well-defined light nucleus, well-defined cytoplasm, with deep chromatophilic substance, there were dark, smaller cells with dispersed Nissl substance, satellite cells, and nerve fibers remained intact during all observation periods.
The obtained data confirm the trophic effect of drugs of the fetoplacental complex. Our experimental study showed that a single subcutaneous injection of cryopreserved placenta causes a reaction of the vessels of the microcirculatory bed of the trigeminal node of rats in the first two weeks of observation in the form of an expansion of the diameter of arterioles, capillaries and venules and an increase in blood filling. The most pronounced phenomena were observed on the 7th day. The obtained data indicate the stimulating effect of the components of the fetoplacental complex on the microcirculatory channel.
After transplantation of the cryopreserved placenta, neurocytes, satellite cells, and nerve fibers remained intact during all observation periods.
EFFECT OF POLYMORPHIC VARIANTS OF AGT2R1 GENE ON HEMODYNAMIC PARAMETERS IN PREMATURE CHILDREN
Authors: Cherniavska Yu.I. 
Published: November 2022

Relevance. Maintaining hemodynamic in premature infants who are being treated in intensive care units is one of the significant challenges in the practice of modern neonatologists and intensivists. The study of AGT2R1 gene polymorphism can help predict the course of organ dysfunction and prevent the development of adverse clinical consequences.
The aim is to study the effect of AGT2R1 gene polymorphism on hemodynamic parameters in premature children with bacterial infections.
Subjects and methods. A prospective cohort study included 143 prematurely born children with bacterial infections: main groups (n=40) had arterial hypotension, control group (n=103) had no arterial hypotension. All patients underwent a standard complex of clinical and laboratory research methods and PCR in order to investigate the A1166C polymorphism of the AGT2R1 gene.
Results. The study has revealed that the CC genotype of AGT2R1 occur significantly more often in premature children with arterial hypotension than in the control group (OR 10.17, p=0.027). As a result of intragroup analysis among the infants with arterial hypotension, stratified according to polymorphic variants of the AGT2R1 gene, we did not find any significant differences in medico-demographic indicators, the frequency of resuscitation measures, hemodynamic indicators. However, prematurely born children with AC+CC genotype compared to carriers of the AA variant genotype had a lower cardiac index (4.5 vs. 3.5 ml/min*m2, p=0.04), which indicates the influence of myocardial dysfunction on the occurrence arterial hypotension
Conclusion. A1168C polymorphism of the AGT2R1 gene affects the hemodynamic disorders in premature children with bacterial infections. Further multifaceted studies on a larger sample of patients are required to confirm this hypothesis.
ROLE OF C-REACTIVE PROTEIN IN ASSESSING EFFICIENCY OF TREATMENT OF PURULENT WOUNDS IN SOFT TISSUES
Authors: Gorodova-Andreeva T. V. , Liakhovsky V. I. , Sydorenko A. V. 
Published: November 2022

Treating purulent wounds of soft tissues using negative pressure has been in the focus of recent medical studies. Among various biochemical indicators, the dynamic changes in the content of C reactive protein (CRP) have not been sufficiently studied yet, and the correlation between the CRP and the application of physical methods of treatment of purulent wounds is still not studied well. The aim of this study is to investigate the changes in CRP indicators in the blood serum in patients with purulent wounds of soft tissues of various localizations during the treatment using vacuum therapy.
Subjects and methods. 89 patients with purulent wounds of soft tissues of various localization participated in the retrospective study. The patients were divided into two groups: I group included patients who received vacuum therapy with instillations of L-arginine under the course of standard treatment (n=44), and II group included patients who received standard vacuum therapy (n =45). Blood samples were taken from patients of both groups to determine the CRP content before surgery and in 5 and 9 days after the beginning of the treatment.
Results. At the first stage of the study, CRP values in the blood serum of all patients averaged 90.4±4.73 mg/l, and at the second stage in 5 days after the first course of vacuum therapy, there was a slight decrease in CRP values which on average were equal to 61.9±3.98 mg/l (p>0.05). At the third stage (after the second course of vacuum therapy, in after 9 days of the treatment), the CRP level decreased compared to the first and second stages and was on average 32.91±3.28 mg/l (р=0.01). In I group of patients, the average CRP level at the first stage was 90.14±4.22 mg/l, and in the second group – 95.66±5.03 mg/l (p>0.05). The CRP content at the 2nd stage in the patients of I group was on average 39.85±4.81 mg/l and 84.13±4.58 mg/l in the patients of II group (p>0.05). At the 3rd stage of the treatment, the average level of CRP was equal to: 12.61±3.27 mg/l in patients of I group and 53.22±3.49 mg/l in patients of II group (р<0.05).
Conclusion. Control of the level of C-reactive protein in blood serum is one of the objective laboratory criteria for evaluating the effectiveness of treatment in patients with purulent wounds of soft tissues of different localization when applying vacuum therapy.
INNOVATIVE APPROACHES TO PREVENTION OF OBSTETRIC HEMORRHAGE DURING ABDOMINAL DELIVERY IN WOMEN WITH PLACENTATION ABNORMALITIES AND HYPERTENSIVE DISORDERS
Authors: Dobrovolska L.M. , Likhachov V.K. , Vaschenko V.L. , Taranovska О.О. , Makarov О.H. 
Published: November 2022

Introduction. The leading factor of obstetric haemorrhage is disrupted uterine contractility. Therefore, at a high risk of obstetric haemorrhage, uterotonic drugs and vasoconstrictors are used immediately after deliverу of a baby. However, the use of ergometrine, carbetocin, and terlipressin can lead to rise in blood pressure that should not be contraindicated for women with preeclampsia.
The purpose of this study is a search for preventive methods, which ensure the reduction of the frequency of massive obstetric blood loss during caesarean section in women with abnormal placenta ion and hypertensive disorders.
Materials and methods. We compared the intraoperative volume of blood loss in 18 women of the main group with abnormal placentation and hypertensive disorders (who received prophylactic devascularization of the uterus) and in 35 women of the comparison group with abnormal placentation, but without hypertension (who received 100 µg of carbetocin intravenously during caesarean section).
Results. No significant difference in the volume of blood loss between women of both groups during both urgent and planned childbirth was noted, despite the fact that the risk of massive blood loss in the main group was significantly higher due to the presence of hypertensive conditions in such women. In the patients of the main group (after devascularization of the uterus), already on day 5 of the postoperative period, the blood flow in the uterine arteries restored and did not differ from that in the patients of the comparison group.
Conclusion. The technique of devascularization of the uterus in patients with placenta previa and hypertensive conditions can be recommended for the prevention of obstetric haemorrhage.
CHANGES IN RETINAL MICROCIRCULATION ACCORDING TO FINDINGS OF OPTICAL COHERENCE TOMOGRAPHY-ANGIOGRAPHY IN PATIENTS AFTER RHEGMATOGENOUS RETINAL DETACHMENT
Authors: Ivanchenko A. , Bezkorovayna I. 
Published: November 2022

The purpose of this study is to conduct a comparative analysis of retinal microcirculation according to OCT -а in patients operated on for rhegmatogenous retinal detachment without macular detachment and with macular detachment. Subjects and Methods: having been checked for inclusion / exclusion criteria eligibility, 116 patients were included in this prospective study: 65 patients after the rhegmatogenous retinal detachment without macular detachment and 51 patients after the rhegmatogenous retinal detachment with macular detachment. Using OCT-а, we analyzed the size of the foveal avascular zone, the density of superficial vessels and the density of deep vessels, the density of choriocapillary vessels in eyes with RRD without detached macula and with detached macula, and then evaluated their correlation with functional and anatomical results through 1.3, 6 and 12 months following the surgical treatment.
Results. In the group without macular detachment, the best-corrected visual acuity improved (on average from 1.02 ± 0.76 to 1.45 ± 0.57) logMAR compared to the initial level, the patients had a lower density of deep vessels in the parafoveal region 58.51-61.35. In the group with macular detachment, the best corrected visual acuity was on average from 0.26 ± 0.28 to 0.33 ± 0.30 logMAR, the patients had a lower average density of superficial vessels in the parafoveal zone 48.81-53.42, a lower average density of deep vessels in the foveal 56.89-60.12 and parafoveal zones 59.98-62.30.
Conclusion. In rhegmatogenous retinal detachment without macular detachment, the final best-corrected visual acuity is related to the parafoveal density of deep vessels (r = − 0.340, p = 0.010). In rhegmatogenous retinal detachment with macular detachment, the best-corrected visual acuity is associated with the foveal density of superficial vessels (r = − 0.451, p = 0.005) and the parafoveal density of deep vessels (r = − 0.418, p = 0.010). When comparing retinal vessels after successful repair of rhegmatogenous retinal detachment without macular detachment and with macular detachment, both study groups had lower vessel density compared to paired eyes (r = − 0.402, p = 0.006).
ASSESSMENT OF THE EFFICIENCY OF REHABILITATION RECOVERY OF CHILDREN WITH CENTRAL NERVOUS SYSTEM DISABILITIES
Authors: Shkolnyk M. B. , Mychalchuk V.M. 
Published: November 2022

The purpose of this work is to assess the effectiveness of the rehabilitation of children with central nervous system disabilities when applying the reflex-loading device "Gravistat".
Material and methods. The method of assessing the effectiveness of rehabilitation measures was carried out before and after a 10-day rehabilitation course according to the generally accepted GMFM scale (Gross Motor Function Measurement Score Sheet). 280 children aged from 4 to 18 years who had impaired functions of the musculoskeletal system due to central nervous system disabilities were examined and then divided into 2 groups: the main test group involved 200 children with disabilities, whose comprehensive rehabilitation program included the device "Gravistat"; the control group included 80 children with disabilities who did not receive the treatment using the "Gravistat" device.
Results. The analysis of the received data of the comparative indicators of both groups before the recovery course showed the absence of a reliable difference in all parameters that were measured. (p>0.05). Comparison of the indicators of the rehabilitation program effectiveness for children of both groups showed a significant increase in indicators after the completion of the rehabilitation course in all measured parameters in children with disabilities of the main group (when using reflex-loading devices) compared to similar indicators in children of the control group. Thus, the indicator "A-Lying and turning" in the main group was 8.82±1.10 points, and in the control group - 7.13±0.82 points; "B-Seats" - 9.20±1.24 and 7.33±0.78 points, respectively; "C-Lying, crawling" - 9.56±1.11 and 7.38±0.74 points; "D-Standing" - 9.78±1.08 and 6.56±0.61 points; "E-Walking, running, jumping" - 10.00±1.02 points in the main group and 6.94±0.66 points in the control group (p<0.05).
Conclusion. The analysis of data evaluating the effectiveness of the rehabilitation program in the children of the main group, when using the "Gravistat" reflex loading device, has shown a reliable improvement in all parameters of the rehabilitation program in comparison with the indicators in the children of the control group.
PELATIHAN PEMBUATAN VIDEO PEMBELAJARAN DI TK ABA KANDANG PANJANG PEKALONGAN
Authors: Nasution Nur Baiti , ‘Adna Syita Fatih , Mardhiyana Dewi 
Published: November 2022

<p>During the era of pandemic of Covid 19 , all schools in Indonesia are forced to implement online learning including the kindergartens. The aim of this activity is to train the teacher of TK ABA Kandang Panjang so that they can create, edit and puvlish video for students learning. The videos are created using android smartphone and edited using Youcut app. Then, the videos are uploaded to Youtube channel of TK ABA Kandang Panjang. There were 3 stages of this activity. They are preparation, implementation, and evaluation. This activity was followed by 6 classroom teacher and the headmaster of the kindergarten. Looking at the evaluation result, it is known that teachers knowledge about creating and editing video using smartphones are increased. However, the Youtube channel has not been used optimally.</p><p><strong> </strong></p><strong>Keywords</strong>: early years education, online learning, kindergarten, learning video
EDUKASI MEMBUAT MINUMAN SERBUK JAHE UNTUK MENINGKATKAN IMUNITAS PADA PERAWAT DALAM MENANGANI PASIEN COVID-19
Authors: Vianti Remilda Armika , Hasanah Nunung 
Published: November 2022

<p>The hospital is a health service agency that focuses on curative efforts. Hospitals are required to have ideal resources to be able to provide the best service to patients. The Covid-19 pandemic that has hit the world is a tough challenge for health services. The increase in new cases is so fast that the graph of the improvement looks very sharp. Positive confirmed cases are also increasing while hospital resources are unable to accommodate the number of patients in the area due to limited isolation rooms and their facilities. RSUD Bendan Kota Pekalongan is a hospital designated by the government to become a line 2 (two) Covid-19 referral hospital. Various problems experienced by the hospital, including the limited number of isolation rooms, the limited number of PPE, the limited number of human resources for health workers. This results in various problems, one of which is the nurse's it can result in stress which results in decreased immunity. Therefore, education to give food supplement like ginger drink, especially nurses. Education is carried out by providing a pocket book on efforts to prevent Covid-19. After being given education services, there was a improvement for motivation and increasing imunity.</p><p> </p><p><strong>Keywords</strong>: Covid-19, nurse, education, ginger drink</p>
ANTI-BACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT, N-HEXANE FRACTION, ETHYL ACETATE FRACTION AND WATER FRACTION FROM DRAGON FRUIT STEM (Hylocereus polyrhizus) AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA)
Authors: Sulistyarini Indah Indah 
Published: November 2022

In dragon fruit cultivation, stems that have been fruited must be pruned and discarded, because they cannot produce fruit again. If this is not used, it will become a waste. Therefore, in this study, it will be developed into an antimicrobial material, because the stems of red dragon fruit (Hylocereus polyrhizus) are known to have several antibacterial compounds. The purpose of this study was to determine the antibacterial activity of ethanol extract, n-hexane, ethyl acetate, and water fractions from dragon fruit stems on the growth of Methicillin-resistant Staphylococcus aureus (MRSA), and to determine the types of compounds that are antibacterial. The result shows that the data on the greatest antibacterial activity was found at a concentration of 30% both in the ethanol extract (1.850cm); n-hexane fraction (1.948 cm); ethyl acetate fraction (1.640 cm) and water fraction (0.884 cm). Meanwhile, the results of contact bioautography showed that the antibacterial compounds of Methicillin-resistant Staphylococcus aureus (MRSA) were flavonoids, saponins, and steroids. Thus, the presence of antibacterial compounds can be further investigated to be developed into topical antibacterial dosage form, as well as cosmetic preparations.
STRATEGI PENGEMBANGAN DESTINASI WISATA DANAU LAET MENGGUNAKAN METODE SWOT DAN QSPM
Authors: Prima Febri , Kurniawan Eddy , Sari Wahyu Wulan 
Published: November 2022

Danau Laet memiliki wisata alam yang sangat potensial untuk dikembangkan. Banyak wisatawan yang berkunjung untuk menikmati atraksi yang ditawarkan, pemandangan alam yang indah dan spot-spot menarik untuk berfoto. Namun didalam pengelolaannya, masih terdapat beberapa kelemahan seperti aksesibilitas infrastruktur yang belum memadai dan strategi pemasaran yang belum maksimal. Penelitian ini bertujuan untuk 1). Mengidentifikasi kekuatan, kelemahan, peluang, dan ancaman dalam pengembangan objek wisata. 2).Menentukan strategi pemasaran yang tepat dalam pengembangan objek wisata. 3). Menentukan prioritas strategi terbaik. Metode yang digunakan dalam penelitian ini ialah menggunakan metode SWOT dan QSPM. Data dikumpulkan melalui observasi, wawancara, dan penyebaran kuesioner. Data yang diidentifikasi meliputi faktor internal dan eksternal dimana data tersebut diolah dan dianalisis untuk menentukan strategi yang tepat dalam pengembangan wisata alam Danau Laet. Berdasarkan hasil analisis, strategi yang tepat dalam pengembangan wisata alam Danau Laet yaitu strategi SO. Strategi SO masuk dalam kuadran 1 dimana posisi strategi ini sangat menguntungkan karena memiliki nilai kekuatan dan peluang yang sangat besar sehingga stakeholder dapat memaksimalkan kondisi tersebut. Adapun prioritas strategi terbaik yaitu memperkenalkan pada wisatawan baik wisatqwan lokal dan asing dengan melakukan promosi yang dapat dikemas secara menarik tentunya dengan memperkenalkan keindahan objek wisata, atraksi-atraksi menarik dan informasi sarana dan prasarana yang tersedia di Wisata Danau Laet.
Increasing comprehensiveness and reducing workload in a systematic review of complex interventions using automated machine learning
Authors: Uthman Olalekan A , Court Rachel , Enderby Jodie , Al-Khudairy Lena , Nduka Chidozie , Mistry Hema , Melendez-Torres GJ , Taylor-Phillips Sian , Clarke Aileen 
Published: November 2022

Background
As part of our ongoing systematic review of complex interventions for the primary prevention of cardiovascular diseases, we have developed and evaluated automated machine-learning classifiers for title and abstract screening. The aim was to develop a high-performing algorithm comparable to human screening.

Methods
We followed a three-phase process to develop and test an automated machine learning-based classifier for screening potential studies on interventions for primary prevention of cardiovascular disease. We labelled a total of 16,611 articles during the first phase of the project. In the second phase, we used the labelled articles to develop a machine learning-based classifier. After that, we examined the performance of the classifiers in correctly labelling the papers. We evaluated the performance of the five deep-learning models [i.e. parallel convolutional neural network (CNN), stacked CNN, parallel-stacked CNN, recurrent neural network (RNN) and CNN–RNN]. The models were evaluated using recall, precision and work saved over sampling at no less than 95% recall.

Results
We labelled a total of 16,611 articles, of which 676 (4.0%) were tagged as ‘relevant’ and 15,935 (96%) were tagged as ‘irrelevant’. The recall ranged from 51.9% to 96.6%. The precision ranged from 64.6% to 99.1%. The work saved over sampling ranged from 8.9% to as high as 92.1%. The best-performing model was parallel CNN, yielding a 96.4% recall, as well as 99.1% precision, and a potential workload reduction of 89.9%.

Future work and limitations
We used words from the title and the abstract only. More work needs to be done to look into possible changes in performance, such as adding features such as full document text. The approach might also not be able to be used for other complex systematic reviews on different topics.

Conclusion
Our study shows that machine learning has the potential to significantly aid the labour-intensive screening of abstracts in systematic reviews of complex interventions. Future research should concentrate on enhancing the classifier system and determining how it can be integrated into the systematic review workflow.

Funding
This project was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme and will be published in Health Technology Assessment. See the NIHR Journals Library website for further project information.