bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer activities of Saudi Juniperus procera extracts and their effects on the regulatory mechanisms in controlling growth of human cancerous cells
Authors: Al-Zahrani Ateeq , Ibraheem Farag , El-Senduny Fardous F. 
Published: June 2022

Abstract
Cancer is one of the most distributed diseases in the world, which has been associated with a high number of mortalities compared to other diseases. Compared to traditional cancer treatment methods such as chemotherapy and radiotherapy, anti-cancer medicinal plants are mor safer due to their minimum side effects. The Juniperus procera plant is one of medicinal plants used in traditional Saudi medicine, and its extract is used to treat many diseases including cancer. In this study, we investigated the anticancer impacts of J. procera extracts and their potential anticancer activities on breast, ovarian and liver cancers with the focus on the first type. Phytochemical analysis revealed that the fruit extract had higher amount of total phenolics while the leaf extract was richer in flavonoids. The fruit extract showed more antioxidant and cytotoxicity activities against breast, ovarian, and liver cancers. MCF-7 and MDA-MB-231, breast cancer cell lines were further investigated using the fruit extract. Both cell lines were arrested in S phase and G1 phase, respectively. Nuclear fragmentations and apoptosis were triggered in both cell lines. ROS was increased and the cell migration was inhibited. PI3K/Akt/mTOR pathway was down regulated. Aromatase gene expression was decreased in MCF-7 and increased in MDA-MB-231. Both extracts were selective toward cancer cells rather than the normal cells (SI > 2). Fruit and leaf extracts have significant antitumor activities, and such activity was more pronounced in the fruit extract than leaf extract. This study highlights the importance of J. procera leaf and fruit as an anti-cancer.
The Relationship Between Menopausal Syndrome and Gut Microbes
Authors: Liu Yaqian , Zhou Ying , Huang Yanmei , Liang Jingtao , Zhu Min , Yao Peixun , Zong Yun , Lang Jianying , Zhang Yingxuan 
Published: June 2022

Abstract
Purpose
The association between gut microbes dysbiosis and menopause syndrome (MPS) is poorly understood. The aim of this study was to explore the relationship between MPS and gut microbes.
Methods
77 MPS patients (P group) and 24 menopausal healthy women (H group) were recruited in this study. Participants were collected their stool specimen and clinical parameters (including demographic data, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), et al ). We looked at the differences in gut microbiota between two groups by 16S ribosomal RNA gene sequencing. LEfSe was used to identify bacteria with varying abundances in different groups. Clinical parameters and microbial species Spearman correlation coefficients were calculated. PICRUSt was used to predict the potential KEGG Ortholog functional profiles of microbial communities.
Results
The abundance of 14 species differed substantially between the MPS and menopausal healthy women (LDA significance threshold > 2.0) according to LEfSe analysis. Using Spearman's correlation analysis, it was discovered that Aggregatibacter segnis, Bifidobacterium animalis, Acinetobacter guillouiae were enriched in menopausal healthy women, with a positive correlation with the E2 and a negative correlation with the FSH and LH (p ༜ 0.05); the abundances of species had a close correlation with the other clinical parameters, including the KI score, hot flash, et al. KEGG L3 metabolic pathways relevant to cardiovascular disease and carbohydrate metabolism were also enriched in the MPS (p ༜ 0.05), according to functional prediction by PICRUST and analyzed by Dunn test.
Conclusion
There were gut microbes dysbiosis in MPS, which is reflected in the deficiency of the abundance of Aggregatibacter segnis, Bifidobacterium animalis and Acinetobacter guillouiae related to the level of sex hormones. In MPS individuals, species with altered abundances and unique functional pathways were found.
Development of a program to determine optimal settings for robotic-assisted rehabilitation of the post-stroke paretic upper extremity: a simulation study
Authors: Takebayashi Takashi , Uchiyama Yuki , Okita Yuho , Domen Kazuhisa 
Published: June 2022

Abstract
Background: Robot-assisted therapy can effectively treat upper extremity (UE) paralysis in patients who experience stroke. Presently, UE, as a training item, is selected according to the severity of the paralysis, which is based on a clinician’s experience. The possibility of objectively selecting robot-assisted training items based on the severity of paralysis was simulated using the item response theory (IRT).Methods: Sample data were generated using Monte Carlo method with 300 random cases. In this simulation, sample data (categorical data with three difficulty values of 0, 1, and 2 [0: too easy, 1: adequate, and 2: too difficult]) with 71 items per case were analyzed. First, the most appropriate method was selected to ensure local independence of the sample data necessary to use IRT. The method was to exclude: items with low response probability (maximum response probability) within a pair in the Quality of Compensatory Movement Score (QCM) 1-point item difficulty curve, items with low item information content within a pair in the QCM 1-point item difficulty curve, and items with low item discrimination. Second, 300 cases were analyzed to determine the most appropriate model (one-parameter or two-parameter item response therapy) to be used and the most favored method to establish local independence. We also examined whether robotic training items could be selected according to the severity of paralysis based on the ability of the person (θ) in the sample data as calculated by IRT.Results: To ensure local independence, excluding items with low response probability (maximum response probability) in a pair in the categorical data 1-point item difficulty curve was effective.Additionally, to ensure local independence, the number of items should be reduced to 61 from 71, indicating that the two-parameter model IRT was an appropriate model. The ability of the person (θ) calculated by IRT suggested that seven training items could be estimated from 300 cases according to severity.Conclusion: From this simulation, it seemed possible to objectively estimate the training items according to the severity of paralysis in a sample of approximately 300 cases using this model.
Differences of professionalism perception on social networking sites between doctors of medicine and dental medicine: Development of e-professionalism assessment compatibility index (ePACI)
Authors: Viskić Joško , Marelić Marko , Poplašen Lovela Machala , Rukavina Tea Vukušić 
Published: June 2022

Abstract
Background:Social networking sites (SNS) have penetrated all aspects of our professional and private life. A new term e-professionalism has emerged which combines traditional values with this new dynamic online environment for health care professionals. Medicine and dental medicine are similar, yet diverging professions. SNS offer valuable tools to reach out to patients on an educational and promotional level for both professions, but bring many dangers to professionalism. The aim of this study was to examine the SNS prevalence, usage habits, and perception of e-professionalism of medical doctors (MDs) and doctors of dental medicine (DMDs) in Croatia. Additionally, to develop an e-professionalism assessment compatibility index (ePACI) and explore differences and shifts in index values of these groups.Methods:A quantitative cross-sectional study on the use of SNS and attitudes about e-professionalism of MDs and DMDs was conducted via email to all MDs and DMDs members of respective chambers. Using the SMePROF rubric for assessment of unprofessional content on Facebook principal component analysis was conducted. ePACI was designed to measure not only perception in line with the expected answer, but also the direction of the shift.Results:Of the 1013 gathered responses, 753 were valid SNS users for further analysis. Facebook (91.6%) and Instagram (63.1%) were the predominant SNS used. Both groups have a good understanding of e-professionalism, however, DMDs are less sensitive to view visual depictions of patients on SNS (χ21=32.119, p<0.001), and endorsements from pharmaceutical companies without conflict-of-interest disclosure (χ21=19.354, p<0.001) as unprofessional.The newly developed ePACI shifts lightly to the conservative side for both for MDs (t=19.033, df=506, p<0.001) and DMDs (t=12.991, df=245, p<0.001). Statistically significantly more conservative ePACI values have health care professionals who are older (r=0.308, p<0.001), who have fewer SNS profiles (rs= -0.142, p<0.001), and who access their profiles less frequently (r= -0.166, p<0.001).Conclusions:MDs and DMDs are heavy SNS users and have an understanding of e-professionalism. The development of the ePACI and subsequent usage in further research, has a direct influence in gathering comparable data and can steer on where efforts in oversight, regulation and education should be pointed.
Seven pediatric Cases with Familial hypomagnesemia with hypercalciuria and nephrocalcinosis
Authors: Aydın Zehra , Cayci Fatma Semsa , Inozu Mihriban , Sahin Ibrahim , Konrad Martin , Bayrakci Umut Selda 
Published: June 2022

Abstract
Purpose: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal-recessive renal tubular disorder. FHHNC is characterized by renal wasting of magnesium (Mg) and calcium (Ca), which subsequently leads to bilateral nephrocalcinosis, renal stones, and chronic renal failure. Here, we report seven patients with FHHNC. Methods: We retrospectively analyzed pediatric cases of FHHNC between 2010-2020. Results: A total of 7 patients, 5 girls (71.4 %) and 2 boys (28.5 %) with a median age of 4 years (min:4 months, max:13 years) and a mean follow-up time of 4.4±3.5 years were included. 3 patients had been diagnosed incidentally. All of the patients had nephrocalcinosis, hypercalciuria and high PTH level. One patient had hypocalcemia and one patient had normal serum magnesium level. All patients had high urine FEMg. Five patients had CLDN 16 mutation, and two patients had CLDN19 mutation. None of them had ocular findings. Three patients had chronic renal failure at the end of the follow-up.Conclusions: We want to draw attention to the FHHNC in children with nephrocalcinosis. FHHNC should be considered in children with normal serum magnesium levels since a normal serum magnesium level does not rule out FHHNC, and high FEMg levels are more significant for the diagnosis.
Relationship between the diffusing capacity of the lung for carbon monoxide (DLCO) and lung adenocarcinoma patterns: new possible insights
Authors: Ventura Luigi , Gnetti Letizia , Milanese Gianluca , Rossi Maurizio , Leo Ludovica , Cattadori Sara , Silva Mario , Leonetti Alessandro , Minari Roberta , Bocchialini Giovanni , Silini Enrico Maria , Tiseo Marcello , Sverzellati Nicola , Carbognani Paolo 
Published: June 2022

Abstract
PURPOSE: This study aimed to evaluate a potential relationship between the diffusing capacity of the lung for carbon monoxide(DLCO) and the aggressiveness of lung adenocarcinoma(ADC).METHODS: Patients who underwent radical surgery for lung ADC between 2001 and 2018 were retrospectively reviewed. DLCO values were dichotomized into DLCOlow(<80% of predicted) and DLCOnormal(≥80%).Relationships between DLCO and ADC histopathological features, clinical features, as well as with overall survival (OS), were evaluated. RESULTS: Four hundred and sixty patients were enrolled, of which 193(42%) were included in the DLCOlow group. DLCOlow was associated with smoking status, low FEV1, micropapillary and solid ADC, tumour grade 3,high tumour lymphoid infiltrate and presence of tumour desmoplasia. In addition, DLCO values were higher in low-grade ADC and progressively decreased in intermediate and high-grade ADC(p=0.024). After adjusting for clinical variables, at multivariable logistic regression analysis, DLCOlow still showed a significant correlation with high lymphoid infiltrate(p=0.017), presence of desmoplasia(p=0.065), tumour grade 3(p=0.062),micropapillary and solid ADC subtypes(p=0.008).To exclude the association between non-smokers and well-differentiated ADC, the relationship between DLCO and histopathological ADC patterns was confirmed in the subset of 377 former and current smokers(p=0.021).At univariate analysis, gender, DLCO, FEV1, ADC histotype, tumor grade, stage, pleural invasion, tumour necrosis, tumour desmoplasia, lymphatic and blood invasion were significantly related with OS. At multivariate analysis, only gender(p<0.001), tumour stage(p<0.001) and DLCO(p=0.050) were significantly related with the OS. CONCLUSIONS: We found a relationship between DLCO and ADC patterns as well as with tumour grade, tumour lymphoid infiltrate and desmoplasia, suggesting that lung damage may be associated with tumour aggressiveness.
Role of umbilical cord blood procalcitonin in the noninvasive diagnosis of fetal inflammatory response syndrome: a pilot study
Authors: Cui Xuewei , Shi Yongyan , Sun Tong , Fu Jianhua 
Published: June 2022

Abstract
Purpose: To evaluate the diagnostic effect of umbilical cord blood procalcitonin (PCT) on fetal inflammatory response syndrome (FIRS). Methods: This prospective study assessed preterm infants (100 with FIRS and 124 controls) with gestational age <32 weeks. The groups were compared in terms of the incidence of complications associated with preterm birth. To identify whether FIRS was an independent risk factor for complications of preterm birth, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multivariable logistic regression models. Finally, we clarified the diagnostic efficiency by receiver operating characteristic curves. Results: Univariate analysis showed that the incidence of natural delivery, premature rupture of membranes (PROM) > 18h, antenatal antibiotic usage, chorioamnionitis, umbilical cord blood PCT, gestational age (GA), small for gestational age (SGA), bronchopulmonary dysplasia (BPD), early-onset sepsis (EOS), necrotizing enterocolitis (NEC), white matter injury (WMI), retinopathy of prematurity (ROP), and mortality were higher in the case group than the control group (p < 0.05). Multivariable analysis confirmed a significant association between FIRS and complications of preterm birth. The level of umbilical cord blood PCT of preterm infants could be used as a noninvasive diagnostic index for FIRS (cut-off value: 0.276 ng/ml). Conclusions: Umbilical cord blood PCT may be a reliable noninvasive diagnostic biomarker for FIRS. Chorioamnionitis, natural delivery, and the level of umbilical cord blood PCT are independent risk factors for FIRS in preterm infants, while GA was a protective factor for FIRS. FIRS is an independent risk factor for BPD, EOS, NEC, WMI and ROP.
Trends in adherence to recommended physical activity and its effects on cardiovascular risk factors in US adults with cardiovascular disease: a cross-sectional study
Authors: Cheng Yuhong , Mou Lin , Li Zhiliang 
Published: June 2022

Abstract
Background: Being physically active is important for cardiovascular health. This study aimed to examine the trend in adherence to the Physical Activity Guidelines (PAG) for aerobic activity among US adults with a history of cardiovascular disease (CVD) and quantified its association with cardiovascular risk factors.Methods: We studied participants from the National Health and Nutrition Examination Survey 2007-08 to 2017-18. Regression models were used to evaluate the significance of the trend and the association between adherence to the PAG with cardiovascular risk factors.Results: A total of 3638 participants were reported to have a history of CVD. The proportion of adherence to PAG significantly increased from 41.5% in 2007-08 to 54.3% in 2017-18. Male had a higher proportion of adherence compared to the female, while the trend in adherence was only significant in females. Adherence to the PAG was significantly associated with decreased levels of waist circumference, body mass index, hemoglobin A1c, and triglycerides.Conclusions: There is a significant increase in the proportion of adherence to the PAG among US adults with a history of CVD from 2007-08 to 2017-18, and adherence to the PAG was associated with better cardiovascular health.
Implementation of Efficient FIR Filter Architectures using Distributed Arithmetic Computation for Digital Channelizer of SDR
Authors: Bhadavath Kiran Kumar , Livinsa Z. Mary 
Published: June 2022

Abstract
Always an efficient and low complexity reconfigurable filter architecture is required for the channel filters of digital channelizer in Software Defined Radio (SDR). In this paper, a block-based reconfigurable FIR filter is proposed using Distributed Arithmetic (DA) Technique. The complexity of the conventional multiplier is replaced with the DA multiplication process and the throughput of the entire filter is increased by block processing. Memory reuse is also achieved in the proposed direct form systolic FIR filter architecture due to parallel processing. The different bandwidth filters and the corresponding coefficients are stored in the LUTs concerning different channels of the digital channelizer. The proper channel selection is used to choose an appropriate filter and partial products are generated using Offset Binary Coding (OBC). Next, the multiplication process is done by the proposed decomposed LUT-based DA technique in the processing blocks of the filter. The proposed filter is coded by Verilog and synthesized by ASIC-based tools from Cadence in 45 nm CMOS technology. The performance parameters such as area, delay, power consumption, ADP, and PDP are evaluated and compared with the state-of-the-art works. The ADP and PDP values are saved by 44.1% and 30% by the proposed OBC-DA-based filter architecture than the conventional DA-based filter architecture, respectively.
Evaluation of mortality prediction using SOFA and APACHE IV tools in trauma and non-trauma patients admitted to the ICU
Authors: Niaz Mehran Karami , Moghadam Nazanin Fard , Aghaei Abbas , Mardokhi Saeed , Sobhani Somayeh 
Published: June 2022

Abstract
Background
Various tools have previously been introduced to predict the recuperation and mortality of patients in intensive care units and to classify them. That tools have particular advantages and disadvantages compared to each other. The present study compared the power of mortality prediction in SOFA and APACHE IV tools in trauma and non-trauma patients admitted to the ICU.
Methods
In this retrospective cohort study, patients admitted to the ICU of Kowsar Hospital in Sanandaj from the beginning of April 2020 to the end (December) of 2020 were assessed. Data were collected in the form of a questionnaire based on APACHE IV and SOFA criteria and the demographic information questionnaire. All collected data were related to the first 24 hours of patients' hospitalization. Data were also analyzed in SPSS V16 software using Chi-square, Mann-Whitney, Cox regression and Pearson correlation coefficients.
Results
This study was performed on 404 patients admitted to the ICU, of whom 273 people (67.6%) were male. 208 patients (51.5%) had been hospitalized due to an outcome resulted from trauma and 196 patients (48.5%) had been hospitalized due to a non-traumatic outcome. The mean age of the patients was 54.76 ± 20.77 years and their average inpatient hospital stay was 10.05 ± 8.49 days. In general, the AUC obtained from APACHE IV tool (0.902) was slightly better than that of SOFA tool (0.895). However, in a specific study of traumatic and non-traumatic patients, it was found that APACHE IV and SOFA tools had better performance in predicting death in, respectively, non-trauma and trauma patients based on the accuracy, AUC and sensitivity.
Conclusions
Based on the results of this study, it was found that the difference between APACHE IV and SOFA tools in predicting death in patients admitted to the ICU was very small but if patients were separately examined for being traumatic and non-traumatic, the APACHE IV function in predicting mortality in non-traumatic cases was better while the SOFA function was better in predicting the death in traumatic cases. This fact represents the applicability of these two tools in different subgroups of patients.
Flutter Analysis of Floating Horizontal-axis Wind Turbine Blades
Authors: Fadaei Saeid , Mazidi Abbas , Afagh Fred , Langlois Robert G. 
Published: June 2022

Abstract
In this study, flutter of blades in floating horizontal-axis wind turbines is investigated. The blade is modeled as a non-uniform Euler-Bernoulli beam in bending and torsion, which can experience large deflections. The discretized form of the aeroelastic governing equations of the blade is obtained by combining blade element momentum theory (BEM) and geometrically exact beam theory (GEBT). To emulate the true physical and geometrical properties of the blade, for each property, a mathematical function that has been fit to the series of data points corresponding to the NREL 5 MW turbine blade is constructed and used in the aeroelastic governing equations. Numerical results are compared with the results obtained from the ABAQUS software and good agreement is observed. Results are presented for both parked and operational wind turbine rotors. Results show the significant effect of the turbine tower rotation, due to wave action, on the aeroelastic stability of the blades. Furthermore, it is shown that coupled motion of the platform as a rigid body with rotor angular velocity can lead to flutter instability at low wind speeds.
Begomoviruses of Solanaceae in the Southern Provinces of Iran
Authors: Ramazani Mohammad Ali , Ayazpour Kavous , Niazmand Ali Reza , Najafipour Gilda 
Published: June 2022

Abstract
Begomoviruses are important plant viruses, especially in Solanaceous plants. This study aimed to identify begomoviruses in the plants of the family Solanaceae in southern Iran. During 2019–2020, 53 samples were collected from plants with viral symptoms from different regions in Fars, Kerman, and Hormozgan provinces. Begomovirus infections were assessed by polymerase chain reaction (PCR) method, using universal primers of PCRv181/Primer Bc. The 500-bp amplified DNA fragment was sequenced in seven samples. A specific primer was used to evaluate the presence of Tomato Leaf Curl New Delhi Virus (ToLCNDV) in the samples with confirmed Begomovirus infection. The DNA of Begomovirus was detected in 22 out of 53 samples, and an expected DNA fragment of 500bp was amplified. Based on a search conducted by the BLAST software and the sequenced DNA fragments, Tomato Yellow Leaf Curl Virus (TYLCV) was found in tomatoes collected from Fars, Kerman, and Hormozgan provinces, Tomato Leaf Curl Palampur Virus (ToLCPMV) from tomato of Hormozgan, peppers from Fars and Hormozgan provinces, and eggplant from Fars province. The obtained results indicated the infection of one pepper sample collected from Hormozgan province to ToLCNDV. The sequences were deposited in the GenBank. According to the results, TYLCV, ToLCPMV, and ToLCNDV were prevalent in the plants of the family Solanaceae in the southern provinces of Iran, and TYLCV was the dominant Begomovirus in this region. Overall, ToLCPMV has a wide host range and is a threat to tomato cultivation. This is the first report of ToLCNDV in pepper from Hormozgan province.