bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palimpsest Wojtyły. Jan Paweł II, polski mesjanizm i katolicka nauka społeczna
Authors: Rojek Paweł 
Published: September 2022

In 1953 Karol Wojtyła started his lectures on Catholic social teaching at the Theological Faculty of the Jagiellonian University. The course was generally based on notes prepared by Professor Jan Piwowarczyk, a former lecturer, removed from teaching for political reasons. For a long time Wojtyła’s own script was not available for researchers. Many commentators speculated about the content of his early lectures; some of them argued that Wojtyła was at that time close to Marxism, whereas others denied that the lectures were actually authored by him. Finally, in 2018, the full version of the lectures was published in Polish. It turns out that Wojtyła usually merely repeated or slightly reformulated Piwowarczyk’s material, though in some cases he added some original content. In this paper I analyse these additions to find some traces of Wojtyła’s earliest views. I argue that they clearly indicate influences of Polish romantic messianism. Wojtyła in a way translated his early inspirations into the language of Catholic social teaching. That is why he wrote about the idea of the Kingdom of God on earth, supported the doctrine of the missions of particular nations and defended the eligious meaning of collective suffering.
Technology as ‘time saver’ and the ‘saviour’ of older adult care:
Authors: Alvsåker Yngvild Brandser , Ågotnes Gudmund 
Published: September 2022

This paper analyses the political articulation and understanding of ‘technology-supported care’ for older adults in central Norwegian public policy documents. In these documents, technology is increasingly presented both as a time saver and a life saver for the welfare state. Drawing on data from document analysis of official green and white papers from the period 1973-2018, the paper describes and seeks answers to how healthcare policies have evolved towards representing a strong ‘techno-optimism’. The primary objective is to analyse how such an optimism have come about as well as understand the underlying assumptions and ideologies supporting it.
Epistemologically, the paper leans on the French sociologist Pierre Bourdieu’s theories on policy and practice, and on how current social practices can be analysed historically. The analysis identifies ‘historical breaks’ regarding how technologies are positioned throughout the last five decades and reveal battles between orthodox and heterodox stances towards technology in care. As such, we discuss the temporal aspects of representations of technology in policies, as well as problematic aspects of what we see at the current or prevalent doxa: a strong belief in technology in care as time- and cost-saving.
Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics
Authors: Grigoruk O. G. , Moskvina T. A. , Tsoy D. A. , Stepanova A. S. , Bazulina L. M. , Sigitova E. S. , Ponomareva T. V. , Ilinskiy V. K. , Bryleva Yu. A. , Samuylenkova O. V. , Bakharev S. Yu. , Pupkova E. E. , Baron A. V. , Fedoskina A. V. 
Published: September 2022

This study was undertaken to analyze the effectiveness of cytological diagnostics of endocervical adenocarcinomas. We compared conventional liquid-based cytology, histology, immunohistochemistry, and molecular testing. A total of 25 endocervical adenocarcinomas, including endocervical adenocarcinomas in situ, were diagnosed using cytological methods over a year. Liquid-based cytology ensured better detection of glandular differentiation signs than conventional cytology. After molecular testing for human papillomavirus (HPV), we performed retrospective analysis of cytological characteristics of all endocervical adenocarcinomas (n = 15).We identified specific cellular characteristics of HPV-associated typical and mucinous adenocarcinomas. We also observed 1 case of non-HPV-related clear-cell and 1 case of non-HPV-related mesonephral adenocarcinoma.Our findings suggest that endocervical adenocarcinomas are a heterogeneous group of tumors. Endocervical adenocarcinomas accounted for 10.7 % of all primary cervical carcinomas (n = 214). Eighty percent of all endocervical adenocarcinomas were HPV-related, whereas the remaining 20 % were HPV-negative. We found no cytological differences between invasive endocervical adenocarcinomas and adenocarcinomas in situ.Mutations detected in some of the patients are an important diagnostic criterion that specifies whether the tumor is rare.
Experience of the usage intraoperative radiation therapy in patients with early breast cancer
Authors: Manikhas A. G. , Gor L. A. , Topuzov E. E. , Oganesyan A. S. , Fedorova O. I. , Kalinin I. V. 
Published: September 2022

Background. Comprehensive treatment of breast cancer includes surgery, radiation therapy and systemic treatment. Radiation therapy plays an integral role in the treatment of early breast cancer. The appointment of a targeted dose of radiation to the bed of the primary tumor reduces the risk of local recurrence.Objective: to evaluate the effectiveness of intraoperative radiation therapy in the treatment of early breast cancer.Materials and methods. A retrospective study was conducted on the basis of the St. Petersburg City Clinical Oncology Center. Patients with organ-preserving surgery and intraoperative radiation therapy were selected. Of the 352 patients, 273 patients met the inclusion/non-inclusion criteria. Inclusion criteria were verified breast cancer, clinical stage I–IIA, tumor size no more than 3 cm, absence of visible axillary lymph nodes and monocentric nature of tumor growth. All patients underwent sectoral resection of the mammary gland with a biopsy of the sentinel lymph nodes and intraoperative radiation therapy.Results. The mean age of the patients was 59 years. For 273 patients, the median follow-up was 59.1 months. During this period, 18 (6.6 %) local recurrences of the disease were noted, of which 7 (39 %) patients with luminal A, 6 (33 %) patients with luminal B, 1 (6 %) patient with luminal B HER2/neu 3+, and 4 (22 %) patients with triple negative breast cancer. Within 3 years of follow-up, recurrence-free survival was 98.5 %, within 5 years – 96.4 %.Conclusion. The use of intraoperative radiation therapy for early breast cancer is an effective and safe treatment method.
Tumor immune microenvironment and apoptotic markers in breast cancer patients carrying <I>BRCA1</I> gene mutations
Authors: Stukan A. I. , Goryainova A. Yu. , Chukhray O. Yu. , Maksimenko S. D. , Imyanitov E. N. , Sharov S. V. , Khachmamuk Z. K. 
Published: September 2022

Background. It is suggested that defects in BRCA1 / 2 genes contribute to a high mutational load and high immunogenicity, which modulates immune microenvironment. At the same time, it was shown that BRCA1 / 2-associated breast cancer tumors do not belong to the category of immunoactive ones. These tumors have low expression of immune response genes and exhibit an immunosuppressive type of microenvironment. This indicates the need of antitumor immune response modulation and maintaining of the optimal balance of tumor CD4/CD8 T-lymphocytes ratio. In addition, there is evidence of the additional evaluation of TP53 mutation in these tumors and disruption of the cell death process, which can also be a factor of resistance to therapy, including PARP inhibitors, and serve as a therapeutic target.Materials and methods. The prospective study included 20 patients with BRCA1-associated breast cancer. BRCA1 / 2 mutations (BRCA1 185delAG, 4153delA, 5382insC, 3819delGTAAA, 3875delGTCT, 300T>G, 2080delA, BRCA2 6174delT) were detected in by real-time polymerase chain reaction. Immunohistochemical study was performed on paraffin embedded tissue blocks by an automated method on a ThermoScentific immunohistotainer using monoclonal antibodies. The expression of markers of tumor-infiltrating CD4+ and CD8+ T-lymphocytes, markers of macrophages (CD68, CD163), apoptosis (Bcl-2, p53), cell adhesion markers (E-cadherin, β-catenin) in breast cancer in carriers of BRCA1 mutations was assessed.Results. High CD4/CD8 ratio, which characterizes immunosuppressive microenvironment, occurred in 75 % of cases. BRCA1 5382insC mutation is associated with high level of CD4+ TILs (p˂0.05), G2 is associated with a low CD4/CD8 ratio (p = 0.039) and a high level of CD163 (p = 0.02, AUC = 0.739); T1 correlates with high levels of CD8+ TILs (p = 0.038) and high levels of CD163 (p = 0.033). High Ki-67 is associated with a lack of Bcl-2 expression (p = 0.04) and a low level of E-cadherin (p = 0.02). Negative expression of Bcl-2 occurred in 75 % of cases. High level of p53 expression has been described as the main type of expression in these tumors, suggesting a combination of TB53 and BRCA1 mutations and a violation of cell death mechanism of in these tumors.Conclusion. Breast cancer tumors of patients with hereditary mutations in BRCA1 gene demonstrate immunosuppressive type of microenvironment and a violation of the cell death mechanism. The main directions of future therapy of these tumors may include tumor immune microenvironment modification and activation of cell death mechanisms.
Prognostic significance of neutrophil to lymphocyte ratio in patients with metastatic breast cancer on the background of eribulin therapy
Authors: Zyuzyukina A. V. , Komissarova V. A. , Popova N. O. , Goldberg V. E. , Zukov R. A. 
Published: September 2022

Background. The neutrophil to lymphocyte ratio (NLR) is a prognostic marker in various carcinomas, including breast cancer. The NLR reflects the balance of systemic immunity and is associated with survival in patients with solid tumors.Aim. This study retrospectively evaluated the significance of the NLR and the absolute lymphocyte count in patients with breast cancer who received eribulin therapy.Materials and methods. The prognostic significance of the NLR and the absolute lymphocyte count in 33 patients with metastatic breast cancer treated with eribulin in 2020–2021 was analyzed.Results. The median follow-up time for patients was 9 [6; 15] months. Twenty-six of 33 (78.8 %) patients progressed. Seven of 33 (21.2 %) patients were censored due to therapy discontinuation, complete discontinuation after 1 course was required in 3 (9.1 %) patients and was associated with the development of hematological toxicity: 1 (3 %) case of a combination of grade 3 leucopenia and grade 3 thrombocytopenia, 2 (6 %) cases of grade 3 neutropenia. According to the analysis results, the NLR was a statistically significant risk factor for progression in patients on eribulin therapy, both without taking into account the influence of other factors (univariate model) and with the underlying influence of the absolute neutrophil count and the absolute lymphocyte count: hazard ratio (95 % confidence interval) was 1.21 [1.04; 1.41], p = 0.015 and 1.30 [1.07; 1.57], p = 0.008, respectively. There was no statistically significant effect of the absolute neutrophil count and the absolute lymphocyte count in both univariate and multivariate models. To illustrate the impact of SNL on the onset of progression, patients were divided into two subgroups based on median SNL: SNL˂ 2.46 and SNL ≥2.46. The median survival in patients with SNL ≥2.46 was 9 months, and in patients with SNL˂ 2.46 it was 15 months.Conclusion. The results of the pilot study state the NLR is a potential prognostic marker of long-term treatment with eribulin for patients with metastatic breast cancer, and can be used in clinical practice.
Western U.S. Geologic Deformation Model for Use in the U.S. National Seismic Hazard Model 2023
Authors: Hatem Alexandra E. , Reitman Nadine G. , Briggs Richard W. , Gold Ryan D. , Thompson Jobe Jessica A. , Burgette Reed J. 
Published: September 2022

Abstract
Fault geometry and slip rates are key input data for geologic deformation models, which are a fundamental component of probabilistic seismic hazard analyses (PSHAs). However, geologic sources for PSHA have traditionally been limited to faults with field-based slip rate constraints, which results in underrepresentation of known, but partially characterized, active faults. Here, we evaluate fault geometries and geologic fault slip rates for the western United States to construct a new geologic deformation model for the U.S. National Seismic Hazard Model 2023 update (NSHM23). In previous NSHM iterations, only faults with published geologic slip rates were included. In the NSHM23 fault sections database compilation, this inclusion criterion was expanded to include faults without known slip rates. In this updated geologic deformation model, preferred slip rates and associated uncertainty distributions are incorporated for faults with slip rates derived from field studies. For faults without site-specific slip rates, we evaluate a suite of uncertainty distributions derived from broad slip rate categories in the U.S. Geological Survey Quaternary Fault and Fold Database. Preferred slip rate distributions are selected via comparison with geodetic strain rates in tectonic subregions. The resultant moment of the geologic deformation model is generally in deficit compared with the geodetic moment within each region. Primary advances in the NSHM23 geologic deformation model include the following: (1) slip rates are presented as preferred values with uncertainties rather than single values; (2) the representation of the western U.S. active fault network is more complete; and (3) the geologic deformation model leverages geodetic information to assess regional constraints on geologic fault slip rates.
GPS Velocity Field of the Western United States for the 2023 National Seismic Hazard Model Update
Authors: Zeng Yuehua 
Published: September 2022

Abstract
Global Positioning System (GPS) velocity solutions of the western United States (WUS) are compiled from several sources of field networks and data processing centers for the 2023 U.S. Geological Survey National Seismic Hazard Model (NSHM). These solutions include both survey and continuous-mode GPS velocity measurements. I follow the data processing procedure of Parsons et al. (2013) for the Uniform California Earthquake Rupture Forecast, version 3 and McCaffrey, Bird, et al. (2013) and Zeng and Shen (2013) for their WUS deformation models in support of the 2014 NSHM update. All GPS velocity vectors are first rotated to a common North American reference frame. I edit the velocities to remove outliers and data with significant influence from volcanism. The solutions are then combined into a final GPS velocity field consisting of 4979 horizontal velocity vectors. I compute strain rates based on these GPS velocities using the method of Shen et al. (2015). These strain rates correlate closely with seismicity rates in the WUS. The results are used for WUS geodetic and geologic deformation modeling in support of the 2023 NSHM update.
Vulgariser les concepts scientifiques dans la presse : Les définitions par métaphore
Authors: Rossi Micaela 
Published: September 2022

La pandémie de COVID-19 a représenté un « moment discursif » (Moirand) fondamental au cours des dernières décennies ; plus en particulier, cet événement a mis à l’épreuve les concepts partagés de « vérité scientifique » (Charaudeau) et d’« expertise » (Vicari). Cette période a été également marquée par une activité de vulgarisation sans précédent de concepts spécialisés, liés aux domaines de la médecine et de la biologie, mais aussi aux domaines de l’économie et de la vie sociale, notamment à travers les canaux médiatiques (presse, radio, télévision, Internet et réseaux sociaux).
L’explication de notions fortement techniques, ainsi que de nouveaux termes issus de la pandémie, a souvent pris des formes variées, parmi lesquelles les tournures définitoires jouent un rôle majeur. Notre contribution se propose de mettre en évidence la fonction de cadrage (framing) que la métaphore peut jouer lorsqu’elle est exploitée comme instrument de définition d’un concept scientifique (Rossi 2018). Nous analyserons à ces fins un corpus de presse française et italienne comprise entre 2020 et 2021, détectant les métaphores utilisées comme reformulations définitoires de concepts liés à la pandémie.
Aerobic Exercise Training as a Potential Cardioprotective Strategy to Attenuate Doxorubicin-Induced Cardiotoxicity
Authors: Kouzi Samir A. , Uddin Mohammad Nasir 
Published: September 2022

Doxorubicin is one of the most commonly used cytotoxic anticancer drugs against several cancers. Although a highly effective anticancer drug, the clinical use of doxorubicin is severely limited by its cardiotoxicity which results in morbidity, poor quality of life, and premature mortality. Only very few clinically accepted methods to minimize doxorubicin-induced cardiac injury are available today, but none of them have proven to be completely successful. Due to limited alternative strategies, a number of potential cardioprotective therapies are currently being investigated for treating and/or preventing doxorubicin-induced cardiotoxicity. Of these potential strategies, aerobic exercise training is the only nonpharmacologic strategy that shows a great deal of promise. Although there are no published human clinical trials, evidence from numerous animal studies suggests that aerobic exercise training, administered prior to, during and/or following doxorubicin therapy, is protective against doxorubicin-induced cardiac injury. Protective properties of exercise training against the cardiotoxicity of doxorubicin have been attributed to a number of potential molecular mechanisms including: enhancing the production of endogenous antioxidant machineries; regulating proapoptotic signaling; stimulating the release, mobilization and homing of cardiac progenitor cells; limiting myocyte turnover; eliciting favorable adaptations in myocardial calcium handling and preventing calcium overload; modulating cardiac AMPK activity; downregulating cardiac autophagy/lysosomal signaling; and reducing myocardial doxorubicin accumulation. Further preclinical and clinical research is needed to decipher and refine the molecular mechanisms underlying the cardioprotective effects of exercise training, as well as to define the nature and magnitude of the effect of exercise on doxorubicin-induced cardiotoxicity in cancer patients. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
Predicting High-Impact Pharmacological Targets by Integrating Transcriptome and Text-Mining Features
Authors: Mayburd Anatoly , Baranova Ancha 
Published: September 2022

Purpose: Novel, “outside of the box” approaches are needed for evaluating candidate molecules, especially in oncology. Throughout the years of 2000-2010, the efficiency of drug development fell to barely acceptable levels, and in the second decade of this century, levels have improved only marginally. This dismal condition continues despite unprecedented progress in the development of a variety of high-throughput tools, computational methods, aggregated databases, drug repurposing programs and innovative chemistries. Here we tested a hypothesis that the economic impact of targeting a particular gene product is predictable a priori by employing a combination of transcriptome profiles and quantitative metrics reflecting existing literature. Methods: To extract classification features, the gene expression patterns of a posteriori high-impact and low-impact anti-cancer target sets were compared. To minimize the possible bias of text-mining, the number of manuscripts published prior to the first clinical trial or relevant review paper, as well as its first derivative in this interval, were collected and used as quantitative metrics of public interest. Results: By combining the gene expression and literature mining features, a 4-fold enrichment in high-impact targets was produced, resulting in a favourable ROC curve analysis for the top impact targets. The dataset was enriched by the highest impact anti-cancer targets, while demonstrating drastic differences in economic value between high and low-impact targets. Known anti-cancer products of EGFR, ERBB2, CYP19A1/aromatase, MTOR, PTGS2, tubulin, VEGFA, BRAF, PGR, PDGFRA, SRC, REN, CSF1R, CTLA4 and HSP90AA1 genes received the highest scores for predicted impact, while microsomal steroid sulfatase, anticoagulant protein C, p53, CDKN2A, c-Jun, and TNSFS11 were highlighted as most promising research-stage targets. Conclusions: A significant cost reduction may be achieved by a priori impact assessment of targets and ligands before their development or repurposing. Expanding a suite of combinational treatments could also decrease the costs, while achieving a higher impact per developed ligand. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
​Effect of Foliar Applied Nitrogen with Growth Regulators (2,4 D, GA3, Amrut-pani) and Soil Applied Potassium on the Management of the Rough-skin Disorder of Nagpur Mandarin (Citrus reticulata Blanco)
Authors: Kalatippi A.S. , Pandey S.K. , Huchche A.D. , Hota Debashish , Kuldeep Dinesh Kumar , Bhooriya Manmohan Singh 
Published: September 2022

Background: Rough-skin disorder mainly occurs in 6-12 years old young and senile orchards of Nagpur mandarin due to excess application or availability of potassium. The characteristics of rough-skinned fruits are large fruit size with rough textured peel, segments are loose intact with rind, improper fruit shape (fruit length to breadth ratio is equal to one or more than one), reduced juice per cent and TSS. Methods: Based on the incidence of rough-skin disorder, an orchard of Nagpur mandarin was earmarked at Hetikundi village of Wardha district, Maharashtra for Mrig bahar during 2020. The selected orchards are 10 years old, spaced at 6 m x 6 m and grafted on Rangpur lime rootstock. At harvest, yield and yield attributes, fruit physical characteristics and critical quality characteristics viz. TSS, acidity, TSS/ acidity ratio and vitamin C content of disordered and normal fruits were recorded according to treatments. Result: Foliar application of plant growth regulators like 2,4-D 15 ppm and GA3 15 ppm and reducing soil application of potassium in high potassium available soils reduced the rough skin and improved the rind texture and physicochemical characteristics at harvesting in mrig bahar.