bluuebunny/crossref_metadata_2025_split huggingface dataset:
Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 1
Authors: Harada Miyuki , Kimura Fuminori , Takai Yasushi , Nakajima Takeshi , Ushijima Kimio , Kobayashi Hiroaki , Satoh Toyomi , Tozawa Akiko , Sugimoto Kohei , Saji Shigehira , Shimizu Chikako , Akiyama Kyoko , Bando Hiroko , Kuwahara Akira , Furui Tatsuro , Okada Hiroshi , Kawai Koji , Shinohara Nobuo , Nagao Koichi , Kitajima Michio , Suenobu Souichi , Soejima Toshinori , Miyachi Mitsuru , Miyoshi Yoko , Yoneda Akihiro , Horie Akihito , Ishida Yasushi , Usui Noriko , Kanda Yoshinobu , Fujii Nobuharu , Endo Makoto , Nakayama Robert , Hoshi Manabu , Yonemoto Tsukasa , Kiyotani Chikako , Okita Natsuko , Baba Eishi , Muto Manabu , Kikuchi Iwaho , Morishige Ken-ichirou , Tsugawa Koichiro , Nishiyama Hiroyuki , Hosoi Hajime , Tanimoto Mitsune , Kawai Akira , Sugiyama Kazuhiko , Boku Narikazu , Yonemura Masato , Hayashi Naoko , Aoki Daisuke , Osuga Yutaka , Suzuki Nao 
Published: January 2022

AbstractIn 2017, the Japan Society of Clinical Oncology (JSCO) published the JSCO Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients. These were the first Japanese guidelines to address issues of oncofertility. In this field of medicine, sustained close cooperation between oncologists and reproductive specialists is essential from the diagnosis of cancer until many years after completion of cancer treatment. These JSCO guidelines were intended to guide multidisciplinary medical staff in considering the availability of fertility preservation options and to help them decide whether to provide fertility preservation to childhood, adolescent, and young adult cancer patients before treatment starts, with the ultimate goal of improving patient survivorship. The guidelines are presented as Parts 1 and 2. This article (Part 1) summarizes the goals of the guidelines and the methods used to develop them and provides an overview of fertility preservation across all oncology areas. It includes general remarks on the basic concepts surrounding fertility preservation and explanations of the impacts of cancer treatment on gonadal function by sex and treatment modality and of the options for protecting/preserving gonadal function and makes recommendations based on 4 clinical questions. Part 2 of these guidelines provides specific recommendations on fertility preservation in 8 types of cancer (gynecologic, breast, urologic, pediatric, hematologic, bone and soft tissue, brain, and digestive).
Numerical simulation on effect of irrigation conditions on water temperature distribution in a paddy field
Authors: Nishida Kazuhiro , Yoshida Shuichiro , Shiozawa Sho 
Published: January 2022

AbstractWater management methods regulate water temperature in paddy fields, which affects rice growth and the environment. To understand the effect of irrigation conditions on water temperature in a paddy field, water temperature distribution under 42 different irrigation models including the use of ICT water management, which enables remote and automatic irrigation, was simulated using a physical model of heat balance. The following results were obtained: (1) Irrigation water temperature had a more significant effect on paddy water temperature close to the inlet. As the distance from the inlet increased, the water temperature converged to an equilibrium, which was determined by meteorological conditions and changes in water depth. (2) Increasing the irrigation rate with higher irrigation water amount increased the extent and magnitude of the effects of the irrigation water temperature. (3) When total irrigation water amount was the same, increasing the irrigation rate decreased the time-averaged temperature gradient effect over time across the paddy field. (4) Irrigation during the lowest and highest paddy water temperatures effectively decreased and increased the equilibrium water temperature, respectively. The results indicate that irrigation management can be used to alter and control water temperature in paddy fields, and showed the potential of ICT water management in enhancing the effect of water management in paddy fields. Our results demonstrated that a numerical simulation using a physical model for water temperature distribution is useful for revealing effective water management techniques under various irrigation methods and meteorological conditions.
Interactions Between the Nocturnal Low-Level Jets and the Urban Boundary Layer: A Case Study over London
Authors: Tsiringakis Aristofanis , Theeuwes Natalie E. , Barlow Janet F. , Steeneveld Gert-Jan 
Published: January 2022

AbstractUnderstanding the physical processes that affect the turbulent structure of the nocturnal urban boundary layer (UBL) is essential for improving forecasts of air quality and the air temperature in urban areas. Low-level jets (LLJs) have been shown to affect turbulence in the nocturnal UBL. We investigate the interaction of a mesoscale LLJ with the UBL during a 60-h case study. We use observations from two Doppler lidars and results from two high-resolution numerical-weather-prediction models (Weather Research and Forecasting model, and the Met Office Unified Model for limited-area forecasts for the U.K.) to study differences in the occurrence frequency, height, wind speed, and fall-off of LLJs between an urban (London, U.K.) and a rural (Chilbolton, U.K.) site. The LLJs are elevated ($$\approx $$
≈
70 m) over London, due to the deeper UBL, while the wind speed and fall-off are slightly reduced with respect to the rural LLJ. Utilizing two idealized experiments in the WRF model, we find that topography strongly affects LLJ characteristics, but there is still a substantial urban influence. Finally, we find that the increase in wind shear under the LLJ enhances the shear production of turbulent kinetic energy and helps to maintain the vertical mixing in the nocturnal UBL.
Inflammatory breast cancer defined: proposed common diagnostic criteria to guide treatment and research
Authors: Jagsi R. , Mason G. , Overmoyer B. A. , Woodward W. A. , Badve S. , Schneider R. J. , Lang J. E. , Alpaugh M. , Williams K. P. , Vaught D. , Smith A. , Smith K. , Miller K. D. ,   Susan G. Komen-IBCRF IBC Collaborative in partnership with the Milburn Foundation
Published: January 2022

Abstract
Purpose
Inflammatory breast cancer is a deadly and aggressive type of breast cancer. A key challenge relates to the need for a more detailed, formal, objective definition of IBC, the lack of which compromises clinical care, hampers the conduct of clinical trials, and hinders the search for IBC-specific biomarkers and treatments because of the heterogeneity of patients considered to have IBC.

Methods
Susan G. Komen, the Inflammatory Breast Cancer Research Foundation, and the Milburn Foundation convened patient advocates, clinicians, and researchers to review the state of IBC and to propose initiatives to advance the field. After literature review of the defining clinical, pathologic, and imaging characteristics of IBC, the experts developed a novel quantitative scoring system for diagnosis.

Results
The experts identified through consensus several “defining characteristics” of IBC, including factors related to timing of onset and specific symptoms. These reflect common pathophysiologic changes, sometimes detectable on biopsy in the form of dermal lymphovascular tumor emboli and often reflected in imaging findings. Based on the importance and extent of these characteristics, the experts developed a scoring scale that yields a continuous score from 0 to 48 and proposed cut-points for categorization that can be tested in subsequent validation studies.

Conclusion
To move beyond subjective ‘clinical diagnosis’ of IBC, we propose a quantitative scoring system to define IBC, based on clinical, pathologic, and imaging features. This system is intended to predict outcome and biology, guide treatment decisions and inclusion in clinical trials, and increase diagnostic accuracy to aid basic research; future validation studies are necessary to evaluate its performance.
Shaming of Tax Evaders: Empirical Evidence on Perceptions of Retributive Justice and Tax Compliance Intentions
Authors: Okafor Oliver Nnamdi 
Published: January 2022

AbstractAlthough naming-and-shaming (shaming) is a commonly used tax enforcement mechanism, little is known about the efficacy of shaming tax evaders. Through two experiments, this study examines the effects of shaming tax evaders on third-party observers’ perceptions of retributive justice and tax compliance intentions, and whether the salience of persuasion of observers moderates these relationships. Based on insights from defiance theory, the message learning model, and persuasive communications, this study predicts and finds that shaming evaders increases observers’ tax compliance intentions. Furthermore, the results show that higher persuasion, which includes sanction and normative appeals, affects observers’ tax compliance intentions. This study also suggests that shaming has a positive effect on perceptions of retributive justice. Importantly, the results reveal that perceptions of retributive justice in shaming punishment mediate the effect of shaming on tax compliance intentions. The implications for theory and practice are discussed.
Mercury toxicity risk and corticosterone levels across the breeding range of the Yellow-breasted Chat
Authors: Mancuso Kristen , Hodges Karen E. , Grosselet Manuel , Elliott John E. , Alexander John D. , Zanuttig Michelle , Bishop Christine A. 
Published: January 2022

AbstractMercury (Hg) is an environmental contaminant that can negatively impact human and wildlife health. For songbirds, Hg risk may be elevated near riparian habitats due to the transfer of methylmercury (MeHg) from aquatic to terrestrial food webs. We measured Hg levels in tail feathers sampled across the breeding range of the Yellow-breasted Chat (Icteria virens), a riparian songbird species of conservation concern. We assessed the risk of Hg toxicity based on published benchmarks. Simultaneously, we measured corticosterone, a hormone implicated in the stress response system, released via the hypothalamus-pituitary-adrenal axis. To better understand range-wide trends in Hg and corticosterone, we examined whether age, sex, subspecies, or range position were important predictors. Lastly, we examined whether Hg and corticosterone were correlated. Hg levels in chats were relatively low: 0.30 ± 0.02 µg/g dry weight. 148 out of 150 (98.6%) had Hg levels considered background, and 2 (1.6%) had levels considered low toxicity risk. Hg levels were similar between sexes and subspecies. Younger chats (<1 year) had higher Hg levels than older chats (>1 year). Hg levels were lowest in the northern and central portion of the eastern subspecies’ range. Corticosterone concentrations in feathers averaged 3.68 ± 0.23 pg/mm. Corticosterone levels were similar between ages and sexes. Western chats had higher levels of corticosterone than eastern chats. Hg and corticosterone were not correlated, suggesting these low Hg burdens did not affect the activity of the hypothalamus-pituitary-adrenal axis. Altogether, the chat has low Hg toxicity risk across its breeding range, despite living in riparian habitats.
Genetic diversity of Cryphonectria parasitica causing chestnut blight in South Tyrol (northern Italy)
Authors: Ahmad Farooq , Baric Sanja 
Published: January 2022

AbstractEuropean chestnut (Castanea sativa) is threatened by the invasive fungus Cryphonectria parasitica, which causes chestnut blight. The virulence of the fungus can be reduced by a group of mycoviruses that can spread among vegetatively compatible strains through hyphal anastomosis. Hypovirulent isolates are used as biocontrol agents, but their efficiency can be diminished by restricted hyphal anastomosis if the variability of vegetative compatibility (vc) types in a population is high. Sexual reproduction could increase the vc type diversity and further complicate biocontrol in a region. Therefore, knowledge of genetic diversity of C. parasitica is important to assess the effectiveness of a biological control program. The present study was performed in the Autonomous Province of Bozen-Bolzano (South Tyrol) in northern Italy, where chestnut cultivation provides an additional income to farmers. The genetic characterization of C. parasitica isolates from 35 chestnut stands and one forest population in different districts of South Tyrol was performed based on the analysis of vegetative incompatibility loci, the mating type locus, and the internal transcribed spacer (ITS) region. In this study, a total of 23 different vc types were found all over South Tyrol with a Shannon diversity index of 1.86. EU-2, EU-1, and EU-13 were the most widespread vc types comprising 51%, 13%, and 9% of the fungal isolates, respectively. Both mating types were present in the region with a ratio close to 1:1. Three different haplotypes were identified based on ITS sequence analysis, which pointed to two introduction events of the fungus to the region and allowed placing C. parasitica from South Tyrol into a larger phylogeographic context.
Metagenomic monitoring of soil bacterial community after the construction of a crude oil flowline
Authors: Bonomo Maria Grazia , Calabrone Luana , Scrano Laura , Bufo Sabino Aurelio , Di Tomaso Katia , Buongarzone Euro , Salzano Giovanni 
Published: January 2022

AbstractThis study aimed to assess the metagenomic changes of soil bacterial community after constructing a crude oil flowline in Basilicata region, Italy. Soils identified a total of 56 taxa at the phylum level and 485 at the family level, with a different taxa distribution, especially in samples collected on 2014. Since microbiological diversity occurred in the soils collected after 2013 (the reference year), we performed a differential abundance analysis using DESeq2 by GAIA pipeline. In the forest area, 14 phyla and 126 families were differentially abundant (− 6.06 < logFC > 7.88) in 2014 compared to 2013. Nine families were differentially abundant in 2015, with logFC between − 3.16 and 4.66, while 20 families were significantly more abundant and 16 less abundant in 2016, with logFC between − 6.48 and 6.45. In the cultivated area, 33 phyla and 260 families showed differential abundance in 2014. In the next year (2015), 14 phyla were significantly more abundant and 19 less abundant, while 29 families were substantially more abundant and 139 less abundant, with fold changes ranging between − 5.67 and 4.01. In 2016, 33 phyla showed a significantly different abundance, as 14 were more abundant and 19 decreased, and 81 families showed a significantly increased amount with logFC between − 5.31 and 5.38. These results hypothesise that the analysed site is an altered soil where the development of particular bacterial groups attends to bioremediation processes, naturally occurring to restore optimal conditions.
Systemic deficiency of GM1 ganglioside in Parkinson’s disease tissues and its relation to the disease etiology
Authors: Ledeen Robert , Chowdhury Suman , Lu Zi-Hua , Chakraborty Monami , Wu Gusheng 
Published: January 2022

AbstractFollowing our initial reports on subnormal levels of GM1 in the substantia nigra and occipital cortex of Parkinson’s disease (PD) patients, we have examined additional tissues from such patients and found these are also deficient in the ganglioside. These include innervated tissues intimately involved in PD pathology such as colon, heart and others, somewhat less intimately involved, such as skin and fibroblasts. Finally, we have analyzed GM1 in peripheral blood mononuclear cells, a type of tissue apparently with no direct innervation, and found those too to be deficient in GM1. Those patients were all afflicted with the sporadic form of PD (sPD), and we therefore conclude that systemic deficiency of GM1 is a characteristic of this major type of PD. Age is one factor in GM1 decline but is not sufficient; additional GM1 suppressive factors are involved in producing sPD. We discuss these and why GM1 replacement offers promise as a disease-altering therapy.
Tracking Hunter-Gatherer Impact on Vegetation in Last Interglacial and Holocene Europe: Proxies and Challenges
Authors: Nikulina Anastasia , MacDonald Katharine , Scherjon Fulco , A. Pearce Elena , Davoli Marco , Svenning Jens-Christian , Vella Emily , Gaillard Marie-José , Zapolska Anhelina , Arthur Frank , Martinez Alexandre , Hatlestad Kailin , Mazier Florence , Serge Maria Antonia , Lindholm Karl-Johan , Fyfe Ralph , Renssen Hans , Roche Didier M. , Kluiving Sjoerd , Roebroeks Wil 
Published: January 2022

AbstractWe review palaeoenvironmental proxies and combinations of these relevant for understanding hunter-gatherer niche construction activities in pre-agricultural Europe. Our approach consists of two steps: (1) identify the possible range of hunter-gatherer impacts on landscapes based on ethnographic studies; (2) evaluate proxies possibly reflecting these impacts for both the Eemian (Last Interglacial, Middle Palaeolithic) and the Early–Middle Holocene (Mesolithic). We found these paleoenvironmental proxies were not able to unequivocally establish clear-cut differences between specific anthropogenic, climatic and megafaunal impacts for either time period in this area. We discuss case studies for both periods and show that published evidence for Mesolithic manipulation of landscapes is based on the interpretation of comparable data as available for the Last Interglacial. If one applies the ‘Mesolithic’ interpretation schemes to the Neanderthal record, three common niche construction activities can be hypothesised: vegetation burning, plant manipulation and impact on animal species presence and abundance. Our review suggests that as strong a case can be made for a Neanderthal impact on landscapes as for anthropogenic landscape changes during the Mesolithic, even though the Neanderthal evidence comes from only one high-resolution site complex. Further research should include attempts (e.g. by means of modelling studies) to establish whether hunter-gatherer impact on landscapes played out at a local level only versus at a larger scale during both time periods, while we also need to obtain comparative data on the population sizes of Last Interglacial and Holocene hunter-gatherers, as these are usually inferred to have differed significantly.
Spatial distribution of turbulent diapycnal mixing along the Mindanao current inferred from rapid-sampling Argo floats
Authors: He Ying , Wang Jianing , Wang Fan , Hibiya Toshiyuki 
Published: January 2022

AbstractThe Mindanao Current (MC) bridges the North Pacific low-latitude western boundary current system region and the Indonesian Seas by supplying the North Pacific waters to the Indonesian Throughflow. Although the previous study speculated that the diapycnal mixing along the MC might be strong on the basis of the water mass analysis of the gridded climatologic dataset, the real spatial distribution of diapycnal mixing along the MC has remained to be clarified. We tackle this question here by applying a finescale parameterization to temperature and salinity profiles obtained using two rapid-sampling profiling Argo floats that drifted along the MC. The western boundary (WB) region close to the Mindanao Islands and the Sangihe Strait are the two mixing hotspots along the MC, with energy dissipation rate ε and diapycnal diffusivity Kρ enhanced up to ~ 10–6 W kg−1 and ~ 10–3 m2 s−1, respectively. Except for the above two mixing hotspots, the turbulent mixing along the MC is mostly weak, with ε and Kρ to be 10–11–10–9 W kg−1 and 10–6–10–5 m2 s−1, respectively. Strong mixing in the Sangihe Strait can be basically attributed to the existence of internal tides, whereas strong mixing in the WB region suggests the existence of internal lee waves. We also find that water mass transformation along the MC mainly occurs in the Sangihe Strait where the water masses are subjected to strong turbulent mixing during a long residence time.
A Multi‑Center, Open‑Label, Single‑Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency
Authors: Santamaria Manuel , Neth Olaf , Douglass Jo A. , Krivan Gergely , Kobbe Robin , Bernatowska Ewa , Grigoriadou Sofia , Bethune Claire , Chandra Anita , Horneff Gerd , Borte Michael , Sonnenschein Anja , Kralickova Pavlina , Ramón Silvia Sánchez , Langguth Daman , Gonzalez-Granado Luis Ignacio , Alsina Laia , Querolt Montse , Griffin Rhonda , Hames Carrie , Mondou Elsa , Price Jeffrey , Sanz Ana , Lin Jiang 
Published: January 2022

Abstract

Purpose
The purpose of this phase 3 study was to evaluate the efficacy, pharmacokinetics (PK), and safety of Immune Globulin Subcutaneous (Human), 20% Caprylate/Chromatography Purified (IGSC 20%) in patients with primary immunodeficiency (PI).

Methods
Immunoglobulin treatment-experienced subjects with PI received 52 weeks of IGSC 20% given weekly at the same dose as the subject’s previous IgG regimen (DAF 1:1); the minimum dose was 100 mg/kg/week. The primary endpoint was serious bacterial infections (SBIs [null vs alternative hypothesis: SBI rate per person per year ≥ 1 vs < 1]). IgG subclasses and specific pathogen antibody levels were also measured.

Results
Sixty-one subjects (19 children [≤ 12 years], 10 adolescents [> 12–16 years], and 32 adults) were enrolled. The rate of SBIs per person per year was 0.017. The 1-sided 99% upper confidence limit was 0.036 (< 1), and the null hypothesis was rejected. The rate of hospitalization due to infection per person per year was 0.017 (2-sided 95% confidence interval: 0.008–0.033) overall. The mean trough total IgG concentrations were comparable to the previous IgG replacement regimen. The average of the individual mean trough ratios (IGSC 20%:previous regimen) was 1.078 (range: 0.83–1.54). The average steady-state mean trough IgG concentrations were 947.64 and 891.37 mg/dL, respectively. Seven subjects had serious treatment-emergent adverse events (TEAEs); none was drug-related. The rate of all TEAEs, including local infusion site reactions, during 3045 IGSC 20% infusions was 0.135. Most TEAEs were mild or moderate.

Conclusions
IGSC 20% demonstrated efficacy and good safety and tolerability in subjects with PI.