bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabry Disease: Current and Novel Therapeutic Strategies. A Narrative
Review
Authors: Palaiodimou Lina , Kokotis Panagiotis , Zompola Christina , Papagiannopoulou Georgia , Bakola Eleni , Papadopoulou Marianna , Zouvelou Vasiliki , Petras Dimitrios , Vlachopoulos Charalampos , Tsivgoulis Georgios 
Published: June 2022

Background:
Fabry disease (FD) is an inherited lysosomal storage disorder, leading to multisystemic manifestations and causing significant morbidity and mortality.

Objective:
The aim of this narrative review is to present the current and novel therapeutic strategies in FD, including symptomatic and specific treatment options.

Methods:
A systematic literature search was conducted to identify relevant studies, including completed and ongoing randomized-controlled clinical trials (RCTs), prospective or retrospective cohort studies, case series and case reports that provided clinical data regarding FD treatment.

Results:
A multidisciplinary symptomatic treatment is recommended for FD patients, personalized according to disease manifestations and their severity. During the last two decades, FD-specific treatments, including two enzyme-replacement-therapies (agalsidase alfa and agalsidase beta) and chaperone treatment with migalastat have been approved for use and allowed for symptoms’ stabilization or even disease burden reduction. More therapeutic agents are currently under investigation. Substrate reduction therapies, including lucerastat and venglustat, have shown promising results in RCTs and may be used either as monotherapy or as complementary therapy to established enzyme-replacement-therapies. More stable enzyme-replacement-therapy molecules that are associated with less adverse events and lower likelihood of neutralizing antibodies formation have also been developed. Ex-vivo and in-vivo gene therapy is being tested in animal models and pilot human clinical trials, with preliminary results showing a favorable safety and efficacy profile.
Dietary Management of Type 1 Diabetes Mellitus with Celiac Disease
Authors: Tayyem Reema F. , Al-Majali Marah Attallah , Burayzat Salma 
Published: June 2022

Abstract:
Celiac disease is diagnosed more commonly with type 1 diabetes, and the most problematic aspect for a child with type 1 diabetes and celiac disease is that most GFD foods have a high glycemic index, while low glycemic index foods are recommended for type 1 diabetes mellitus. As a result, dietary controls becomes more difficult. Diet management could improve the elevated HbA1c levels. The aim of this review is to illustrate the clinical features and diagnostic considerations, as well as current knowledge of common pathogenic features such as genetics, environmental risk factors, and the gut microbiome of type 1 diabtes and celiac disease. Also, the importance of diet management on glycemic control and growth rate in patients with type 1 diabetes mellitus and celiac disease has been discussed. PubMed and Google Scholar databases were searched. Reports published from the years 1969 to 2021 that focused on the role of type 1 diabetes mellitus and celiac disease, and to examine the types of diet on glycemic control, growth rate, and quality of life. Only a few studies on the effects of a carbohydrate count gluten-free diet on glycemic control, growth rate, and quality of life in patients with type 1 diabetes mellitus and celiac disease have been conducted. There have been few studies showing that the dietary intervention helps to achieve and maintain normal blood glucose and blood pressure levels, a healthy lipid profile, and a healthy body weight. Studies stated that a low-carbohydrate diet had the greatest effect on improving glycemic control and insulin parameters.
Withania somnifera: The Wonder Plant with Withanolide E and J Inhibit
Inflammatory Mediator AP-1 Factor
Authors: Lamani Babu , Chavadapur Srushti Sandu , Biradar Shivaleela , Joga Rajappa 
Published: June 2022

Background:
Inflammation is a natural biological response of the body tissues to harmful stimuli, such as damaged cells, irritants or pathogens and it is a protective response involving blood vessels, immune cells and molecular mediators. Activator Protein-1 (AP-1) is a dimer composed of both homo and hetero dimers with jun and fos sub families. The heterodimer cfos-cjun complex is up regulated in several inflammatory diseases such as asthma, rheumatoid arthritis, psoriasis etc. Since ancient time, several plants were used as anti-inflammatory sources. Withania somnifera is a vital plant having well documented anti-inflammatory properties. In this study, the phytochemicals of Withania somnifera are used to study the inhibitory effect on inflammatory mediator AP-1 factor.

Objective:
Determination of inhibitory effect of Withania somnifera phytochemicals against AP-1 factor (cfos-cjun complex).

Method:
In the present study, phytochemicals of Withania somnifera were retrieved from IMPPAT database and all the retrieved molecules were employed for screening of in-silico pharmacological properties using in-silico tools such as SwissADME and ProTox II. Further, Molecular interactions of receptor and the ligands were carried out by Autodock 4.1 tool.

Results:
Total 90 phytochemicals of Withania somnifera were subjected for IMPPAT database. Among those 21 Phytochemicals shown the appropriate drug similarity characteristics. Autodock 4.1 tool used to analyse the binding effectiveness of these 21 phytochemicals. The excellent inhibitory action in comparison to others was shown by Withanolide E and Withanolide J molecules. Interactions pattern showed that SER and ARG amino acids participate in the formation of drug hydrogen bonds.

Conclusion:
Among the 90 phytochemicals of Withania somnifera, only two molecules showed potential ligand binding ability. Further, in-vitro studies may validate the findings.
Management of the Development of the Travel and Hospitality Industry in the Russian Federation
Authors: Vostrova E. I. 
Published: June 2022

Relevance. Our country presents a unique variety of socio-cultural traditions in different regions, ethnic groups and tourist routes in several climatic zones. The sudden COVID-19 pandemic left its mark on the functioning of the Russian tourism industry during this period. Managing the development of domestic tourism in Russia with the creation of new routes through unique natural and ethnocultural places is especially important in the context of the Covid-19 pandemic.The purpose of the study is to identify tools for managing the development of the Russian tourism industry.Objectives. To achieve this goal, the author studied state programs for the development of the tourism industry, modern sociological scientific approaches to the study of the regional image, key indicators of the development of the tourism sector, conducted five focus groups with a youth audience.Methodology. In the course of work on the study, the author used the method of systemic and structural-functional approaches to the consideration of the regional image, key indicators of tourism development, as well as the focus group method.Results. During discussions in five focus groups, the author proposed a list of tools for the development of the travel and hospitality industry and new routes for Russians to travel.Conclusions. The Russian Federation has tremendous opportunities for the multifaceted disclosure and development of the tourism industry. The COVID-19 pandemic, which led to the closure of the borders of other states, has become another factor making it possible for Russians to open up new places within the country. For the integrated development of the Russian tourism industry, global and local solutions and tools are needed to support the development of the industry.
Machine Learning in Health Promotion and Behavioral Change: Scoping Review
Authors: Goh Yong Shian , Ow Yong Jenna Qing Yun , Chee Bernice Qian Hui , Kuek Jonathan Han Loong , Ho Cyrus Su Hui 
Published: June 2022

Background
Despite health behavioral change interventions targeting modifiable lifestyle factors underlying chronic diseases, dropouts and nonadherence of individuals have remained high. The rapid development of machine learning (ML) in recent years, alongside its ability to provide readily available personalized experience for users, holds much potential for success in health promotion and behavioral change interventions.

Objective
The aim of this paper is to provide an overview of the existing research on ML applications and harness their potential in health promotion and behavioral change interventions.

Methods
A scoping review was conducted based on the 5-stage framework by Arksey and O’Malley and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews) guidelines. A total of 9 databases (the Cochrane Library, CINAHL, Embase, Ovid, ProQuest, PsycInfo, PubMed, Scopus, and Web of Science) were searched from inception to February 2021, without limits on the dates and types of publications. Studies were included in the review if they had incorporated ML in any health promotion or behavioral change interventions, had studied at least one group of participants, and had been published in English. Publication-related information (author, year, aim, and findings), area of health promotion, user data analyzed, type of ML used, challenges encountered, and future research were extracted from each study.

Results
A total of 29 articles were included in this review. Three themes were generated, which are as follows: (1) enablers, which is the adoption of information technology for optimizing systemic operation; (2) challenges, which comprises the various hurdles and limitations presented in the articles; and (3) future directions, which explores prospective strategies in health promotion through ML.

Conclusions
The challenges pertained to not only the time- and resource-consuming nature of ML-based applications, but also the burden on users for data input and the degree of personalization. Future works may consider designs that correspondingly mitigate these challenges in areas that receive limited attention, such as smoking and mental health.
Asian Americans’ Views of their Identities as Asians in <em>Eleanor & Park</em>: A Socio-Psychological Approach
Authors: Afifah Aulia Nur , Rokhman Muh Arif 
Published: June 2022

This research analyzes how Asian American characters, Mindy Sheridan, Park Sheridan, and Josh Sheridan, in the novel Eleanor & Park view their identities as Asians. This research aims to understand how Asian American characters view their identities as Asians and what factors influence their views. The analysis of this research was conducted using the social psychology approach supported by Tajfel and Turner’s (2004) social identity theory and Atkinson, Morten, and Sue’s (1998) minority identity development model. This research shows that Asian American characters’ views of their identity as Asian are influenced by the values believed by the dominant group in their social environment.
Access to Justice as a Social Determinant of Health: The Basis
Authors: Jassar Sunam 
Published: June 2022

Health disparity in Canada is continuing to grow with marginalized communities being disproportionately affected. Policies and actions implemented by the federal government have been ineffective in addressing underlying causes of poor health. Framing access to justice as a social determinant of health is a necessary first step to establish a comprehensive and interdisciplinary approach to address poor health outcomes. Through an analysis of the limitations of access to justice as a legal term and the application of access to justice in health outcomes, this article hopes to foster further collaboration between the medical and legal communities in this area. art I of this paper argues the need to expand the scope of access to justice beyond the legal realm. Part II highlights the increasing health disparity within Canada and critiques the current approach. Part III outlines the ways in which health disparity can be improved if access to justice is recognized as a social determinant of health. The paper concludes with discussing progress that can be made in both the legal and medical community as a result of widening the scope of access to justice. Through an analysis of the limitations of access to justice as a legal term and the application of access to justice in health outcomes, this paper hopes to foster further collaboration between the medical and legal communities in this area.
The Use of Sidescan Sonar to Detect Large Benthic Marine Debris in Niterói Harbor-Guanabara Bay/SE Brazil
Authors: Oliveira Lucas Chiarelli de , Baptista Neto José Antonio , Villena Helio Heringer , Melo Gustavo Vaz , Drabinski Thiago L. , Fonseca Estefan Monteiro da 
Published: June 2022

Abstract. Marine debris constitute a global concern that pollutes the world’s oceans, including deep benthic habitats where little is known about the extent of the problem. SideScan Sonar systems are able to provide near-photographic high-resolution images of underwater areas, for a wide variety of objectives, including production of nautical charts and detection of underwater bathymetric features. Lately this technology has been used as a tool to detect debris on the seafloor that may be hazardous for living organisms and finally for humans. Harbor activities were the most common contributors of benthic debris. Little is known about the extent of the problem in the Guanabara Bay, Rio de Janeiro, regarding benthic debris distribution and their influence in the bottom sediment. The present study analyzes the spatial distribution and type of marine benthic debris in the area of Niterói Harbour. The study identified great amount of benthic debris, including tires, anchors, cables or linear features, sunken vessels, wooden or metal bars and pillars.Keywords: anthropogenic marine debris; benthic habitats, marine debris, estuarine pollution, Guanabara Bay O uso de sonar de varredura lateral para detectar grandes detritos marinhos bentônicos no Porto de Niterói - Baía de Guanabara/SE BrasilResumo. Os detritos marinhos são uma preocupação global que poluem os oceanos do mundo, incluindo habitats bentônicos profundos, onde pouco se sabe sobre a extensão do problema. O sistema de sonar de varredura lateral é capaz de fornecer imagens quase fotográficas de alta resolução de áreas subaquáticas, para uma ampla variedade de objetivos, incluindo a produção de cartas náuticas e detecção de características batimétricas subaquáticas. Ultimamente, essa tecnologia tem sido usada como uma ferramenta para detectar detritos no fundo do mar que podem ser perigosos para os organismos marinhos vivos e, finalmente, para os humanos. As atividades portuárias foram as que mais contribuíram para os detritos bentônicos. Pouco se sabe sobre a extensão do problema na Baía de Guanabara em relação à distribuição de detritos bentônicos e sua influência no sedimento de fundo. O presente estudo analisa a distribuição espacial e o tipo de detritos bentônicos marinhos na área do Porto de Niterói. Na área estudada foi observada grande quantidade de detritos bentônicos, incluindo: pneus, âncoras, cabos ou feições lineares, embarcações afundadas, barras e pilares de madeira ou metal.Palavras-chave: detritos marinhos antropogênicos; habitats bentônicos, detritos marinhos, poluição estuarina, Baía de Guanabara
New Knowledge Update on Mafic Dyke Swarms of Minas Gerais (Brazil): Fragments of Ancient Large Igneous Provinces Highlighted by Aeromagnetometry
Authors: Chaves Alexandre de Oliveira , Pires Ana Clara da Cruz , Brasil Mateus Filipe Andrade 
Published: June 2022

Abstract. Mafic dyke swarms can be related to important geological events such as the activity of mantle plumes, the formation of large igneous provinces (LIP), the break-up/dispersing of supercontinents or they can even be related to orogenic compressional settings. Updated and available aeromagnetometric, geological, geochemical and geochronological information confirms the existence of seven mafic dyke swarms of basaltic composition in the State of Minas Gerais (Brazil). Six of them (Archean Lavras swarm, Paleoproterozoic Pará de Minas – now understood as subswarms I/II – and Januária – previously understood as Mesoproterozoic in an incorrect way – swarms, Neoproterozoic Formiga swarm, Mesozoic Transminas and Santos-RJ or Serra do Mar swarms) are representative of crustal extensional settings and remnants of ancient LIPs, many of which are associated with mantle plumes and with the formation of important sedimentary basins stored in Minas Gerais. One swarm (Paraopeba) has genesis linked to compressional setting during Transamazonian (Rhyacian-Orosirian) Orogeny.Keywords: magnetometry, mafic dykes, compressional and extensional settings, LIP, mantle plumes, São Francisco Craton, mobile belts. Nova Atualização do Conhecimento sobre Enxames de Diques Máficos de Minas Gerais (Brasil): Fragmentos de Antigas Grandes Províncias Ígneas Evidenciados pela AeromagnetometriaResumo. Enxames de diques máficos podem estar relacionados a eventos geológicos importantes, como a atividade de plumas do manto, a formação de grandes províncias ígneas (LIP), a quebra/dispersão de supercontinentes ou mesmo a ambientes compressionais orogênicos. Dados atualizados e disponíveis de aeromagnetometria, geologia, geoquímica e geocronologia confirmam a existência de sete enxames de diques de composição basáltica no estado de Minas Gerais (Brasil). Seis deles (enxame Lavras de idade Arqueana; enxames Pará de Minas e Januária de idade Paleoproterozoica – Januária era incorretamente entendido anteriormente como Mesoproterozoico e Pará de Minas é agora entendido como subenxames I/II; enxame Formiga de idade Neoproterozoica; enxames Transminas e Santos-RJ ou Serra do Mar de idade Mesozoica) são representantes de regimes extensionais da crosta continental e remanescentes de antigas LIPs, muitas das quais são associadas com plumas mantélicas e com a formação de importantes bacias sedimentares em Minas Gerais. Um enxame (Paraopeba) tem sua origem relacionada a regime compressional durante o Ciclo Orogênico Transamazônico (Riaciano-Orosiriano). Palavras-chave: magnetometria, diques máficos, regimes compressionais e extensionais, LIP, plumas mantélicas, Craton São Francisco, cinturões móveis.
Comparison between permeability estimates in a carbonate reservoir of Campos Basin using empirical and mathematical approaches
Authors: Carrasquilla Abel Gonzalez , Mureb Pedro 
Published: June 2022

Abstract. The permeability estimate, using geophysical well logs, is an important and difficult task in a reservoir characterization, which is usually done with empirical models or statistical regression. Thus, logs were used to achieve this goal in two wells of a carbonate reservoir in Campos Basin, together with geological information and laboratory measurements on rock samples. The test Well A10 was zoned in electrofacies and models were built for each one. Next, the hydraulic flow units were defined and correlated to the logs and to the electrofacies. The same was done in a blind test in Well A3. The Principal Component Analysis, Cluster and Discriminant techniques, Multiple Linear Regression, Alternate Conditional Expectation and Hydraulic Flow Unit were used. The quality of the estimates was calculated using the Mean Absolute Error and the Coefficient of Determination. At Well A10, the Hydraulic Flow Unit was the most promising approach. The Alternate Conditional Expectation, without zoning, was the closest to experimental laboratory data in Well A3. These results indicate that all methods are feasible in inferring permeability, however, an inadequate classification of zones can lead to erroneous estimates.Keywords: carbonate reservoir, permeability estimates, multivariate statistics, well logs, laboratory measurements. Comparação entre estimativas da permeabilidade em um reservatório carbonático da Bacia de Campos usando abordagens empíricas e matemáticasResumo. A estimativa da permeabilidade, usando perfis de poços, é uma tarefa importante e difícil na caracterização de reservatórios, a qual é normalmente feita com modelos empíricos ou regressão estatística. Com esse fim, os perfis de poços juntamente com informações geológicas e medições de laboratório em amostras de rocha foram usados em dois poços de um reservatório carbonático da Bacia de Campos. O poço de teste A10 foi zoneado em eletrofácies e modelos foram construídos para cada uma. As unidades de fluxo hidráulico foram definidas e correlacionadas aos perfis a às eletrofácies. Isso foi feito num teste cego no poço A3. As técnicas Análise de Componentes Principais, de Cluster e Discriminante, Regressão Linear Múltipla, Expectativa Condicional Alternada e Unidade de Fluxo Hidráulico foram utilizadas. A qualidade das estimativas foi calculada com o Erro Médio Absoluto e o Coeficiente de Determinação. No Poço A10, a Unidade de Fluxo Hidráulico foi a abordagem mais promissora. A Expectativa Condicional Alternada, sem zoneamento, foi a técnica mais próxima dos dados experimentais de laboratório no poço A3. Esses resultados indicam que todos os métodos são viáveis na inferência da permeabilidade, porém, uma classificação inadequada das zonas pode levar a estimativas errôneas.Palavras-chave: reservatório carbonático, estimativas de permeabilidade, estatísticas multivariadas, perfis de poços, medições laboratoriais.
Acute Adhesive Small Bowel Obstruction: a Comparative Analysis of Open and Laparoscopic Surgery
Authors: Timerbulatov Sh. V. , Sibaev V. M. , Timerbulatov V. M. , Zabelin M. V. , Timerbulatov M. V. , Sagitov R. B. , Gafarova A. R. 
Published: June 2022

Background. Acute adhesive small bowel obstruction (AASBO) is a common surgical emergency requiring immediate interventions. AASBO is a usual indication for both small bowel resection and adhesiolysis. Postoperative adhesions cause 60% of small bowel obstructions.Materials and methods. An analysis of treatment outcomes is presented for 197 acute adhesive small bowel obstruction patients; 63 patients had urgent laparotomy, and 134 were scheduled for laparoscopy. The examination included physical, laboratory, radiological methods (abdominal radiography, ultrasound, CT scan), laparoscopy and intra-abdominal pressure monitoring.Results and discussion. Of 134 patients scheduled for laparoscopic adhesiolysis, only 46.2% had laparoscopy completed, and 53.8% required conversion to laparotomy. The main rationale for conversion were massive adhesions, intraoperative haemodynamic instability, a need for intestinal decompression, as well as rare complications. Laparoscopic operations were reported with the lower vs. laparotomy rates of surgical complications (6.4 vs. 12.69%), mortality (6 vs. 6.3%), shorter hospital stays (6.5 vs. 12 days) and operation times (75 vs. 118 min, respectively).Conclusion. Laparoscopic surgery in acute adhesive small bowel obstruction was feasible in 31.47% patients and in 46.2% — after a diagnostic laparoscopy; however, a thorough patients selection for laparoscopic adhesiolysis is necessary. The first estimated should be the patient’s haemodynamic stability, the severities of condition, adhesions and comorbid cardiorespiratory pathology. Grade I—II adhesions are an indication for laparoscopic surgery.