bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Technique for Monitoring Infant Feelings Using IoT
Authors: prasad saurabh , Prasad Ramjee 
Published: April 2022

Abstract
Human bond communication( HBC ) is a concept where we try to communicate our feelings observed by the five sensory organs namely eye, ear, nose, tongue, skin. This concept is in initial stage and till date we are able to transfer only those data which is observed by the eye and ear using modern communication technology. To communicate data we generally use human understandable communication language and advance technology. Main problem arises when we try to get information from an infant. Infant does not know any type of human understandable communication language or technology. To know infant feelings observed by the sensory organs is a challenging task. The objective of research is to protect infant by knowing what they are feeling and to develop, manufacture cost effective, efficient with highest level of efficiency to aggregate or segregate data point based on local, domestic, regional and global level .Our proposed paper, a prototype system which is capable enough to know and transfer infant’s feelings. Here we have used Internet of Things ( IoT ) technology to know feelings of an infant and protecting them from Sudden Infant Death Syndrome ( SIDS ).
Formulation, Characterization, and Antibacterial Study of Microsponge-
Loaded Gel of Clarithromycin for Topical Drug Delivery
Authors: Pahwa Shilpa , Tomar Mohit Kumar , Tyagi Lalit Kumar , Gupta Chitra , Maan Preeti , Sethi Vandana Arora 
Published: April 2022

Background:
Microsponge drug delivery systems comprise spherical and porous micro-spheres for prolonged topical drug delivery. These systems considerably reduce the undesirable side effects, offering improved patient compliance and reduced dosing frequency.

Objective:
The present study focused on developing topical controlled release preparations of microsponges-loaded gel of clarithromycin to cure bacterial skin infections.

Materials and Methods:
Four batches of microsponges (F1, F2, F3, and F4) of clarithromycin (CLR) containing fixed amounts of clarithromycin (100 mg), dichloromethane (5 ml), polyvinyl al-cohol (5 % w/v) and distilled water (25 ml) with varying polymer concentrations were prepared by the quasi-emulsion solvent diffusion method and evaluated for % Production Yield, % drug content, % encapsulation efficiency, particle size, polydispersity index (PDI) and % drug release characteris-tics. The selected microsponge formulation (F3) was incorporated in Carpopol 934 gel for topical application. The prepared gel (CLRMS-F3 Gel) was evaluated for physical characteristics, pH, spreadability, viscosity, and in vitro drug release. Furthermore, the gel formulation was compared with pure clarithromycin gel for antibacterial activity against the gram-positive (S. aureus) and gram-negative strain (E. coli.) using the cup and plate method.

Results and Discussion:
The F3 microsponge formulation exhibited a production yield of 83.75%, drug content (21.5 ± 0.50 %), and encapsulation efficiency of 86.04 ± 2.30%. Their particle size was satisfactory (3.80 ± 0.01 μm), and they were found to be spherical and porous in nature. F3 microsponges released 69.36 ± 1.27% of the drug over a period of 8 hrs and were incorporated into the gel formulations. The gel prepared using F3 microsponges was transparent, homogenous, and exhibited a pH of 6.8 ± 0.02, spreadability of 9.92 ± 0.44 g/cm, and viscosity of 35370.17 ± 493.09 centipoises. The CLRMS-F3 gel released 82.13 ± 0.47% drug in 12 hrs using a zero-order kinetic. The antibacterial activity studies revealed a higher potency against both S. aureus and E. coli of the prepared CLRMS-F3 gel compared to pure CLR gel and azithromycin standard.

Conclusion:
Based on the above study, it may be concluded that microsponges’ gel formulation can be potentially useful in improving topical drug delivery of antibacterial agents and can give better therapeutic efficacy.
The Associations Between Racially/Ethnically Stratified COVID-19 Tweets and COVID-19 Cases and Deaths: Cross-sectional Study
Authors: Liu Xiaohui , Kar Bandana , Montiel Ishino Francisco Alejandro , Onega Tracy , Williams Faustine 
Published: April 2022

Background
The COVID-19 pandemic exacerbated existing racial/ethnic health disparities in the United States. Monitoring nationwide Twitter conversations about COVID-19 and race/ethnicity could shed light on the impact of the pandemic on racial/ethnic minorities and help address health disparities.

Objective
This paper aims to examine the association between COVID-19 tweet volume and COVID-19 cases and deaths, stratified by race/ethnicity, in the early onset of the pandemic.

Methods
This cross-sectional study used geotagged COVID-19 tweets from within the United States posted in April 2020 on Twitter to examine the association between tweet volume, COVID-19 surveillance data (total cases and deaths in April), and population size. The studied time frame was limited to April 2020 because April was the earliest month when COVID-19 surveillance data on racial/ethnic groups were collected. Racially/ethnically stratified tweets were extracted using racial/ethnic group–related keywords (Asian, Black, Latino, and White) from COVID-19 tweets. Racially/ethnically stratified tweets, COVID-19 cases, and COVID-19 deaths were mapped to reveal their spatial distribution patterns. An ordinary least squares (OLS) regression model was applied to each stratified dataset.

Results
The racially/ethnically stratified tweet volume was associated with surveillance data. Specifically, an increase of 1 Asian tweet was correlated with 288 Asian cases (P<.001) and 93.4 Asian deaths (P<.001); an increase of 1 Black tweet was linked to 47.6 Black deaths (P<.001); an increase of 1 Latino tweet was linked to 719 Latino deaths (P<.001); and an increase of 1 White tweet was linked to 60.2 White deaths (P<.001).

Conclusions
Using racially/ethnically stratified Twitter data as a surveillance indicator could inform epidemiologic trends to help estimate future surges of COVID-19 cases and potential future outbreaks of a pandemic among racial/ethnic groups.
Casting Without Reduction Versus Closed Reduction With or Without Fixation in the Treatment of Distal Radius Fractures in Children: Protocol for a Randomized Noninferiority Trial
Authors: Garcia-Rueda Maria Fernanda , Bohorquez-Penaranda Adriana Patricia , Gil-Laverde Jacky Fabian Armando , Aguilar-Sierra Francisco Javier , Mendoza-Pulido Camilo 
Published: April 2022

Background
Acute treatment for distal radius fractures, the most frequent fractures in the pediatric population, represents a challenge to the orthopedic surgeon. Deciding on surgical restoration of the alignment or cast immobilization without reducing the fracture is a complex concern given the remodeling potential of bones in children. In addition, the lack of evidence-based safe boundaries of shortening and angulation, that will not jeopardize upper-extremity functionality in the future, further complicates this decision.

Objective
The authors aim to measure functional outcomes, assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Physical Function v2.0 instrument. The authors hypothesize that outcomes will not be worse in children treated with cast immobilization in situ compared with those treated with closed reduction with or without percutaneous fixation. The authors also aim to compare the following as secondary outcomes: ulnar variance and fracture alignment in the sagittal and coronal planes, range of motion, pressure ulcers, pain control, radius osteotomy due to deformity, pseudoarthrosis cure, and remanipulation.

Methods
This is the protocol of a randomized noninferiority trial comparing upper-extremity functionality in children aged 5 to 10 years, after sustaining a distal radius fracture, treated with either cast immobilization in situ or closed reduction with or without fixation in a single orthopedic hospital. Functional follow-up is projected at 6 months, while clinical and radiographic follow-up will occur at 2 weeks, 3 months, and 9 months.

Results
Recruitment commenced in July 2021. As of January 2022, 23 children have been randomized. Authors expect an average of 5 patients to be recruited monthly; therefore, recruitment and analysis should be complete by October 2024.

Conclusions
This experimental design that addresses upper-extremity functionality after cast immobilization in situ in children who have sustained a distal fracture of the radius may yield compelling information that could aid the clinician in deciding on the most suitable orthopedic treatment.

Trial Registration
ClinicalTrials.gov NCT05008029; https://clinicaltrials.gov/ct2/show/NCT05008029

International Registered Report Identifier (IRRID)
DERR1-10.2196/34576
The Use of Electronic Consultations in Outpatient Surgery Clinics: Synthesized Narrative Review
Authors: Payne Thomas , Kevric Jasmina , Stelmach Wanda , To Henry 
Published: April 2022

Background
Electronic consultations (eConsults) are an increasingly used form of telemedicine that allows a nonspecialist clinician to seek specialist advice remotely without direct patient-specialist communication. Surgical clinics may see benefits from such forms of communication but face challenges with the need for intervention planning.

Objective
We aimed to use the Quadruple Aim Framework to integrate published knowledge of surgical outpatient eConsults with regard to efficacy, safety, limitations, and evolving use in the era of COVID-19.

Methods
We systematically searched for relevant studies across four databases (Ovid MEDLINE, Embase, Scopus, and Web of Science) on November 4, 2021, with the following inclusion criteria: English language, published in the past 10 years, and data on the outcomes of outpatient surgical eConsults.

Results
A total of 363 studies were screened for eligibility, of which 33 (9.1%) were included. Most of the included studies were from the United States (23/33, 70%) and Canada (7/33, 21%), with a predominant multidisciplinary focus (9/33, 27%). Most were retrospective audits (16/33, 48%), with 15% (5/33) of the studies having a prospective component.

Conclusions
The surgical eConsult studies indicated a possible benefit for population health, promising safety results, enhanced patient and clinician experience, and cost savings compared with the traditional face-to-face surgical referral pathway. Their use appeared to be more favorable in some surgical subspecialties, and the overall efficacy was similar to that of medical subspecialties. Limited data on their long-term safety and use during the COVID-19 pandemic were identified, and this should be the focus of future research.
Cognitive Function, Mental Health, and Quality of Life in Siblings of Preterm Born Children: Protocol for a Systematic Review
Authors: Silva Wnurinham , Virtanen Eeva , Kajantie Eero , Sebert Sylvain 
Published: April 2022

Background
Children and adults born preterm are at increased risk of cognitive impairments, mental health disorders, and poorer quality of life. Epidemiological studies have shown that the impact of preterm birth extends to the immediate family members; however, existing research have focused on parents, and little attention has been given to siblings.

Objective
The aim of the systematic review described in this protocol is to synthesize currently available evidence on the impact of exposure to preterm birth (ie, having a sibling born preterm) on cognition, mental health, and quality of life of term born siblings (index child) of preterm born children, and to critically appraise the evidence.

Methods
This protocol outlines a systematic review designed in accordance with the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols) checklist. We will include all studies that assess outcomes in siblings of children born preterm. Quantitative and qualitative studies will be eligible for the systematic review, and only studies in English will be included. Firstly, search will be conducted electronically on PubMed, Scopus, Embase, Mednar, and opengrey.eu databases and, secondly, manually in Google Scholar and reference lists. The search strategy will include keywords and synonyms, Boolean operators, and text words (ie, within title and abstract). The team of reviewers will screen the search results, extract data from eligible studies, and critically appraise the studies. Analysis will involve both descriptive and quantitative approaches. Meta-analysis will be conducted if appropriate.

Results
This systematic review was registered on PROSPERO (International Prospective Register of Systematic Reviews) on December 18, 2020, and it is currently in progress. The findings will be synthesized to determine the effect of preterm birth on full-term siblings and the quality of the available evidence.

Conclusions
The evidence derived from this study will shed light on gaps and limitations in the field of preterm birth, more specifically, the effect of preterm birth on full-term siblings. In addition, we hope that understanding the impact of preterm birth on family members will inform targeted interventions and policies for those identified at high risk and how to mitigate health risks.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42021222887; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021222887

International Registered Report Identifier (IRRID)
DERR1-10.2196/34987
Innovative Technology–Based Interventions to Reduce Stigma Toward People With Mental Illness: Systematic Review and Meta-analysis
Authors: Rodríguez-Rivas Matías E , Cangas Adolfo J , Cariola Laura A , Varela Jorge J , Valdebenito Sara 
Published: April 2022

Background
Stigma toward people with mental illness presents serious consequences for the impacted individuals, such as social exclusion and increased difficulties in the recovery process. Recently, several interventions have been developed to mitigate public stigma, based on the use of innovative technologies, such as virtual reality and video games.

Objective
This review aims to systematically review, synthesize, measure, and critically discuss experimental studies that measure the effect of technological interventions on stigmatization levels.

Methods
This systematic review and meta-analysis was based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines and included studies in English and Spanish published between 2016 and 2021. Searches were run in 5 different databases (ie, PubMed, PsycInfo, Scopus, Cochrane Library, and ScienceDirect). Only randomized controlled trials were included. Two independent reviewers determined the eligibility, extracted data, and rated methodological quality of the studies. Meta-analyses were performed using the Comprehensive Meta-Analysis software.

Results
Based on the 1158 articles screened, 72 articles were evaluated as full text, of which 9 were included in the qualitative and quantitative syntheses. A diversity of interventions was observed, including video games, audiovisual simulation of hallucinations, virtual reality, and electronic contact with mental health services users. The meta-analysis (n=1832 participants) demonstrated that these interventions had a consistent medium effect on reducing the level of public stigma (d=–0.64; 95% CI 0.31-0.96; P<.001).

Conclusions
Innovative interventions involving the use of technologies are an effective tool in stigma reduction, therefore new challenges are proposed and discussed for the demonstration of their adaptability to different contexts and countries, thus leading to their massification.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42021261935; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021261935
A Photography-based, Social Media Walking Intervention Targeting Autonomous Motivations for Physical Activity: Semistructured Interviews With Older Women
Authors: Robertson Michael C , Swartz Maria Chang , Christopherson Ursela , Bentley Jason R , Basen-Engquist Karen M , Thompson Debbe , Volpi Elena , Lyons Elizabeth J 
Published: April 2022

Background
Older adult women are at risk for negative health outcomes that engaging in sustained physical activity can help prevent. However, promoting long-term maintenance of physical activity in this population has proven to be a challenge. Increasing autonomous motivations (ie, intrinsic, integrated, and identified regulations) for physical activity may facilitate enduring behavior change. Digitally delivered games for health that take a celebratory technology approach, that is, using technology to create new ways to experience valued behaviors and express valued beliefs, may be a useful way to target autonomous motivations for physical activity. Formative research with the target population is needed to design compelling intervention content.

Objective
The objective of this study is to investigate older adult women’s reactions to and thoughts about a photography-based, social media walking game targeting autonomous motivations for physical activity.

Methods
During an individual semistructured interview, a moderator solicited feedback from 20 older adult women (age range 65-74 years) as part of formative research to develop a social media game featuring weekly walking challenges. The challenges were designed to target autonomous motivations for physical activity. Interviews were audio-recorded and transcribed verbatim. Two reviewers conducted thematic content analysis on interview transcripts.

Results
We identified 3 overarching themes in qualitative data analysis. These reflected the playful experiences, value, and acceptability associated with the intervention challenges. Generally, participants understood what the challenges were asking them to do, proffered appropriate example responses, and indicated that the challenges would be enjoyable. Participants reported that the intervention content afforded many and varied playful experiences (eg, competition, discovery, exploration, expression, fellowship, humor, nurture, sensation). Further, participants indicated that the intervention increased their motivation for physical activity, occasioned meaningful shifts in perspective, increased their knowledge of various topics of interest, provided an opportunity to create valued connection with others, and provided health-related benefits. Participants suggested the intervention emphasize local history, nature, and cultural events.

Conclusions
The photography-based, social media walking game with relatively simple game mechanics was well received and judged to be apt to bring about a wide variety of emotive experiences. A clear, geographically specific identity emerged as a key driver of interest for intervention content. Taking a celebratory technology approach holds promise for targeting autonomous motivations for physical activity in older adult women.
Characterization of False or Misleading Fluoride Content on Instagram: Infodemiology Study
Authors: Lotto Matheus , Sá Menezes Tamires , Zakir Hussain Irfhana , Tsao Shu-Feng , Ahmad Butt Zahid , P Morita Plinio , Cruvinel Thiago 
Published: April 2022

Background
Online false or misleading oral health–related content has been propagated on social media to deceive people against fluoride’s economic and health benefits to prevent dental caries.

Objective
The aim of this study was to characterize the false or misleading fluoride-related content on Instagram.

Methods
A total of 3863 posts ranked by users’ total interaction and published between August 2016 and August 2021 were retrieved by CrowdTangle, of which 641 were screened to obtain 500 final posts. Subsequently, two independent investigators analyzed posts qualitatively to define their authors’ interests, profile characteristics, content type, and sentiment. Latent Dirichlet allocation analysis topic modeling was then applied to find salient terms and topics related to false or misleading content, and their similarity was calculated through an intertopic distance map. Data were evaluated by descriptive analysis, the Mann-Whitney U test, the Cramer V test, and multiple logistic regression models.

Results
Most of the posts were categorized as misinformation and political misinformation. The overperforming score was positively associated with older messages (odds ratio [OR]=3.293, P<.001) and professional/political misinformation (OR=1.944, P=.05). In this context, time from publication, negative/neutral sentiment, author’s profile linked to business/dental office/news agency, and social and political interests were related to the increment of performance of messages. Although political misinformation with negative/neutral sentiments was typically published by regular users, misinformation was linked to positive commercial posts. Overall messages focused on improving oral health habits, side effects, dentifrice containing natural ingredients, and fluoride-free products propaganda.

Conclusions
False or misleading fluoride-related content found on Instagram was predominantly produced by regular users motivated by social, psychological, and/or financial interests. However, higher engagement and spreading metrics were associated with political misinformation. Most of the posts were related to the toxicity of fluoridated water and products frequently motivated by financial interests.
Integral transforms of the Hilfer-type fractional derivatives
Authors: Costa Felix , Soares Junior Cesar Alves , Jarosz Stefânia 
Published: April 2022

In this paper, some important properties concerning the Hilfer-type fractional derivatives are discussed. Integral transforms for these operators are derived as particular cases of the Jafari transform. These integral transforms are used to derive a fractional version of the fundamental theorem of calculus.
Keywords: Integral transforms, Jafari transform, κ-gamma function, κ-beta function, κ-Hilfer fractional derivative, κ-Riesz fractional derivative, κ-fractional operators, (κ,ρ)-Hilfer fractional derivative.
Quão big o seu data deve ser?
Authors: Baltar Ronaldo , Baltar Claudia Siqueira 
Published: April 2022

Esse conteúdo digital foi criado como parte da atividade de capacitação
”Introdução ao R e RStudio para ciência social computacional”. É uma
iniciativa de formação e difusão científica
do Observatório de Populações e
Políticas Púbicas (ObPPP) e do
Programa de Formação
Complementar de Graduação em Pesquisa Social Computacional (InfoSoc),
ambos vinculados ao Dept.º C.
Soc. / CLCH, Universidade Estadual de Londrina (UEL), Paraná - Brasil
Tracking Tangible Asset Ownership and Provenance with Blockchain
Authors: Sheldon Mark D. 
Published: April 2022

ABSTRACT
Blockchain transactions are recorded in a shared and append-only repository that multiple parties verify, validate, and agree upon. While initially used to keep track of digital assets, blockchains now track the ownership and provenance of tangible assets. An inherent challenge in using blockchain for this task involves keeping the status of a tangible asset in the physical world in sync with its non-fungible token on a blockchain. While several blockchains are already being used in this manner, specific implementation details are fragmented. In response, this study examines four stages of tracking tangible assets using a consortium's permissioned blockchain, including: design and governance of a blockchain, asset creation, asset transfer, and asset retirement. Based on this analysis, this study proposes a framework of risk considerations and control objectives to evaluate the extent to which a unique blockchain serves as a reliable transaction repository for tracking the ownership and provenance of tangible assets.