bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the relationships between philosophy of technology, cybernetics, and aesthetics with their impacts on Latin America
Authors: Leopold Cornelie 
Published: January 2022

AbstractThere had been interesting interactions between philosophical reflections, technical developments and the work of artists, poets and designers, starting especially in the 1950s and 1960s with a stimulating cell in Stuttgart and Ulm in Germany spreading mutual international interactions. The paper aims to describe the philosophical background of Max Bense with his research on the intellectual history of mathematics and the upcoming studies on technology and cybernetics. Together with communication theories and semiotics, new aesthetics such as cybernetic aesthetics had been worked out, based on the notions of information and sign. This background stimulated international students, artists and researchers from different creative disciplines for methodical approaches leading to first computer art experiments. The interrelations in these fields with Latin America are in the focus of these studies. Students, artists, and poets from Latin America, especially Brazil, came to Germany for studies and exhibitions in the creative scientific cell around Max Bense. Some of them stayed in Europe, but the exchange developed also in the opposite direction, traveling to and working in Latin America. Some of those fruitful international interrelations will be described and reflected.
A refined derived Torelli theorem for enriques surfaces, II: the non-generic case
Authors: Li Chunyi , Stellari Paolo , Zhao Xiaolei 
Published: January 2022

AbstractWe prove that two Enriques surfaces defined over an algebraically closed field of characteristic different from 2 are isomorphic if their Kuznetsov components are equivalent. This improves and completes our previous result joint with Nuer where the same statement is proved for generic Enriques surfaces.
A new variety of chondrocoracoideus muscle, or an additional head of pectoralis major muscle
Authors: Zielinska Nicol , Ruzik Kacper , Georgiev Georgi P. , Dimitrova Iva N. , Tubbs R. Shane , Olewnik Łukasz 
Published: January 2022

AbstractThe pectoralis major and pectoralis minor muscles are located in the anterior chest wall. This region is characterized by high morphological variability. During dissection an additional muscle was found, originating from the lateral border of the pectoralis major muscle. After fusion it passed into the tendinous part coursing under the insertion of the pectoralis major muscle, then formed a common junction with the short head of the biceps brachii muscle, the distal attachment of which is on the coracoid process. Such an accessory structure could lead to neurovascular compression and cause thoracic outlet syndrome, of which pain is usually the first symptom. This muscle has not been described in the literature so far and for that reason we can name the present case as an unique structure.
Immune checkpoint inhibitors: immune-related adverse events, healthcare utilization, and costs among commercial and Medicare Advantage patients
Authors: Gunturu Krishna S. , Pham Timothy T. , Shambhu Sonali , Fisch Michael J. , Barron John J. , Debono David 
Published: January 2022

Abstract
Background
Immune checkpoint inhibitors (ICI) are increasingly used across multiple cancer types and stages and little is known about real-world outcomes. This study sought to determine healthcare utilization, costs, immune-related adverse events (irAEs), and all-cause mortality of single-agent versus combination ICI in the USA.

Materials and methods
This is a retrospective study conducted with 2016–2018 data from the HealthCore Integrated Research Database, consisting of commercial and Medicare-insured adult patients with a cancer diagnosis using ICI in the USA. Outcomes were healthcare utilization, costs, and irAEs (FDA-recognized and others) up to 1-year post-index between patients using ICI monotherapy (mono, PD-1/PD-L1 inhibitor) and combination therapy (combo, PD-1/PD-L1 with CTLA-4 inhibitors).

Results
In total, 9084 patients received monotherapy and 904 patients received combo therapy. Mean age 65 years for mono and 58 years for combo. Overall, the combo arm had higher rates of FDA-recognized irAEs (67.4% vs. 45.9%), especially endocrinopathies (27.7% vs 14.7%) and dermatitis (25.9% vs. 12.4%). All-cause mortality over 1-year follow-up was similar, 30.7% in mono vs 30.8% in combo arms. The combo group had higher rates of all-cause inpatient hospitalizations (55.4% mono vs 65.6% combo) and emergency department (ED) visits (33.7% mono vs 41.4% combo). IrAE-related hospitalizations were higher in combo (55.2% vs 42.1%). IrAE-related ED visits were 15.7% mono vs 22.7% combo. This increased toxicity and health care utilization was reflected in significant differences in healthcare costs. Stark differences were seen in all-cause medical costs as well as costs related to inpatient and ED utilization and costs attributed to irAEs.

Conclusions
Higher rates of irAEs, healthcare utilization, and costs occur with combination immunotherapy. As further indications are approved for combination ICI, our study highlights the real-world tradeoffs involved with combination therapy regarding burdens of toxicity and increased healthcare utilization.
Am Limit? – Einschätzungen zur Grundwasserbewirtschaftung im Großraum Grünstadt (Rheinland-Pfalz)
Authors: Bitzer Frank , Baumeister Christoph , Kampf Jochen , Schykowski Martin 
Published: January 2022

ZusammenfassungIm Großraum Grünstadt erfolgt die Wasserversorgung weitgehend dezentral aus Grundwasserleitern des Buntsandsteins. Dieser ist aufgrund der geologisch-tektonischen Verhältnisse räumlich komplex gegliedert. In Verbindung mit Abschätzungen zu Grundwasserfließrichtungen und Altersdatierungen ist eine Gliederung in bilanzierbare Teilräume möglich.Daten zu Grundwasserständen und zur Grundwasserbeschaffenheit weisen auf mitunter erhebliche Veränderungen seit etwa 1960 hin. Daten zu den Grundwasserentnahmen liegen erst ab 2013 vor. Die annähernd konstanten Absenkungsraten können als Entwicklung in der späten instationären Phase langfristiger, gering schwankender Grundwasserentnahmen interpretiert werden.Auf Basis der Wasserbilanz für den zentralen Bilanzraum wurde die dort zur Bilanzdeckung notwendige Grundwasserneubildung abgeschätzt. Sie wurde den Ergebnissen zweier methodisch unterschiedlicher Grundwasserneubildungsmodelle gegenübergestellt. Die dokumentierten Absenkungen lassen sich mit dem Neubildungsmodell auf Basis des flächendifferenzierten Bodenwasserhaushaltsmodells GWN-BW in Einklang bringen. Für den zentralen bilanzierten Teilraum ist von einer langfristig über der Grundwasserneubildung liegenden Grundwasserentnahme auszugehen.
A macroscopic approach for stress-driven anisotropic growth in bioengineered soft tissues
Authors: Lamm L. , Holthusen H. , Brepols T. , Jockenhövel S. , Reese S. 
Published: January 2022

AbstractThe simulation of growth processes within soft biological tissues is of utmost importance for many applications in the medical sector. Within this contribution, we propose a new macroscopic approach for modelling stress-driven volumetric growth occurring in soft tissues. Instead of using the standard approach of a-priori defining the structure of the growth tensor, we postulate the existence of a general growth potential. Such a potential describes all eligible homeostatic stress states that can ultimately be reached as a result of the growth process. Making use of well-established methods from visco-plasticity, the evolution of the growth-related right Cauchy–Green tensor is subsequently defined as a time-dependent associative evolution law with respect to the introduced potential. This approach naturally leads to a formulation that is able to cover both, isotropic and anisotropic growth-related changes in geometry. It furthermore allows the model to flexibly adapt to changing boundary and loading conditions. Besides the theoretical development, we also describe the algorithmic implementation and furthermore compare the newly derived model with a standard formulation of isotropic growth.
A mathematical model and mesh-free numerical method for contact-line motion in lubrication theory
Authors: Pang Khang Ee , Ó Náraigh Lennon 
Published: January 2022

Abstract
We introduce a mathematical model with a mesh-free numerical method to describe contact-line motion in lubrication theory. We show how the model resolves the singularity at the contact line, and generates smooth profiles for an evolving, spreading droplet. The model describes well the physics of droplet spreading–including Tanner’s Law for the evolution of the contact line. The model can be configured to describe complete wetting or partial wetting, and we explore both cases numerically. In the case of partial wetting, the model also admits analytical solutions for the droplet profile, which we present here.

Article highlights

We formulate a mathematical model to regularize the contact-line singularity for droplet spreading.

The model can be solved using a fast, accurate mesh-free numerical method.

Numerical simulations confirm that the model describes the quantitative aspects of droplet spreading well.
Uniform and scalable sampling of highly configurable systems
Authors: Heradio Ruben , Fernandez-Amoros David , Galindo José A. , Benavides David , Batory Don 
Published: January 2022

AbstractMany analyses on configurable software systems are intractable when confronted with colossal and highly-constrained configuration spaces. These analyses could instead use statistical inference, where a tractable sample accurately predicts results for the entire space. To do so, the laws of statistical inference requires each member of the population to be equally likely to be included in the sample, i.e., the sampling process needs to be “uniform”. SAT-samplers have been developed to generate uniform random samples at a reasonable computational cost. However, there is a lack of experimental validation over colossal spaces to show whether the samplers indeed produce uniform samples or not. This paper (i) proposes a new sampler named , (ii) presents a new statistical test to verify sampler uniformity, and (iii) reports the evaluation of and five other state-of-the-art samplers: , , , , and . Our experimental results show only satisfies both scalability and uniformity.
A prioritised inventory of crop wild relatives and wild harvested plants of Tunisia
Authors: El Mokni Ridha , Barone Giulio , Maxted Nigel , Kell Shelagh , Domina Gianniantonio 
Published: January 2022

AbstractAn inventory of crop wild relatives (CWR) and wild harvested plants (WHP) occurring in Tunisia, based on the integration of the last available floristic checklists, is presented. The taxa were prioritised according to economic value of the related crop, potential for crop improvement, threat status, endemism, inclusion in the ITPGRFA (Annex I) and average annual contributions to dietary energy (kilocalories) per capita per day by applying a scoring system based on 4 priority levels. Of a total of 2912 taxa belonging to the Tunisian Flora, 2504 CWR and/or WHP (86% of the total), from 143 families and 686 genera, were identified, 2445 of which are CWR and 847 are WHP. In detail, 1654 are solely CWR and 59 are WHP only, whereas 788 are both CWR and WHP. The final priority list for active conservation includes 1036 CWR (43% of the total CWR taxa), with 139 taxa rated as high priority, 660 medium priority and 237 low priority. The final priority list for WHP is composed of 344 taxa and includes eight high priority, 254 medium priority and 82 low priority taxa. Our results confirm Tunisia as a hotspot of CWR and WHP diversity in the Mediterranean area. The inventory here proposed provides the basis for the development and implementation of a more targeted national CWR/WHP conservation strategy for Tunisia.
A Spatial Connectivity Approach to Landscapes of Conflict: Julius Caesar and the Assault to Puig Ciutat (NE Iberian Peninsula)
Authors: Rubio-Campillo Xavier , Ble Eduard , Pujol Àngels , Sala Roger , Tamba Robert 
Published: January 2022

AbstractLandscape plays a vital role in the development of military campaigns through the definition of geostrategic landmarks that structure the control of the territory, the imposition of constraints to the movement of armies and the identification of features that facilitate defence against attackers. These factors are linked to the study of past spatial mobility which is typically done by finding optimal pathways between pairs of points using Least-Cost Path analysis. This emphasis on optimality may not be ideal for case studies that need a general approach to spatial connectivity such as the study of conflict-related dynamics. Connectivity modelling based on Circuit Theory (CT) is an alternative approach to spatial mobility that captures the connectivity of an entire region identifying not only optimal paths but also bottlenecks, dead-ends and any other spatial feature that may impact movement. We present here a framework to study landscapes of conflict using connectivity modelling; the framework combines CT, visibility analysis and statistical hypothesis testing to understand the reasons behind the assault and destruction of Puig Ciutat (NE Iberian Peninsula) during Julius Caesar’s civil war. Results suggest that the site exerted decisive control over a highly connected area linking two possible logistical bases (Emporion and Massalia) to the armies fighting at Ilerda (49 BC).
Dedekind and Wolffian Deductive Method
Authors: Ferreirós José , Lassalle-Casanave Abel 
Published: January 2022

AbstractDedekind’s methodology, in his classic booklet on the foundations of arithmetic, has been the topic of some debate. While some authors make it closely analogue to Hilbert’s early axiomatics, others emphasize its idiosyncratic features, most importantly the fact that no axioms are stated and its careful deductive structure apparently rests on definitions alone. In particular, the so-called Dedekind “axioms” of arithmetic are presented by him as “characteristic conditions” in thedefinitionof the complex concept of asimply infinitesystem. Making sense of Dedekind’s method may be dependent on an analysis of the classical model of deductive science, as presented by authors from the eighteenth and early nineteenth centuries. Studying the modern reconstructions of Euclidean geometry, we show that they did not presuppose deductive independence of the axioms from the definitions. Authors like Wolff elaborated a mathematicsbased on definitions, and the Wolffian model of deductive science shows significant coincidences with Dedekind’s method, despite the great differences in content and approach. Wolff had a conception of definitions asgenetic, which bears some similarities with Kant’s idea of synthetic definitions: they are understood as positing the content of mathematical concepts and introducing thought objects (Gedankendinge) that are the objects of mathematics. The emphasis on the spontaneity of the understanding, which can be found in this philosophical tradition, can also be fruitfully related with Dedekind’s idea of the “free creation” of mathematical objects.
The role of microRNA-155 in glomerular endothelial cell injury induced by high glucose
Authors: He Kaiying , Chen Zhan , Zhao Jing , He Yang , Deng Rongrong , Fan Xin , Wang Jianqin , Zhou Xiaochun 
Published: January 2022

Abstract
Objective
To investigate the role of microRNA-155-5p on apoptosis and inflammatory response in human renal glomerular endothelial cells (HRGEC) cultured with high glucose.

Methods
The primary HRGEC were mainly studied, light microscopy was used to detect changes in cell morphology. Quantitative Real Time-Polymerase Chain Reaction, Western Blot, immunofluorescence were aimed to observe the mRNA and protein expression levels of target gene ETS-1, downstream factors VCAM-1, MCP-1 and cleaved caspase-3 in each group after high glucose treatment as well as transfection with miR-155 mimics or inhibitor.

Results
The expression of inflammatory factors and apoptosis of HRGEC cells increased under high glucose treatment. Compared with normal-glucose treatment, the expression of microRNA-155 markedly increased in HRGECs treated with high-glucose, as well as the mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3. Overexpression of microRNA-155 remarkably downregulated mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3, whereas miRNA-155 knockdown upregulated their levels. In addition, HRGEC cells were transfected with miR-155 mimics and ETS-1 siRNA with high glucose stimulation. The expression of ETS-1 was positively correlated with the expression of downstream factors VCAM-1 and MCP-1. These results suggest that ETS-1 can mediate endothelial cell inflammation by regulating VCAM-1 and MCP-1.

Conclusion
MiR-155 can negatively regulate the expression of target gene ETS-1 and its downstream factors VCAM-1, MCP-1 and cleaved caspase-3, thus mediating the inflammatory response and apoptosis of HRGEC.
Exogenous Melatonin Alleviates Skeletal Muscle Wasting by Regulating Hypothalamic Neuropeptides Expression in Endotoxemia Rats
Authors: Duan Jianfeng , Cheng Minhua , Xu Yali , Chen Yan , Gao Tao , Gu Qin , Yu Wenkui 
Published: January 2022

AbstractTo investigate whether exogenous melatonin (MLT) could alleviate skeletal muscle wasting by regulating hypothalamic neuropeptides expression. Adult male Sprague Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) (10 mg/kg), followed by MLT (30 mg/kg/day) or saline for 3 days. Hypothalamic tissues and skeletal muscle were obtained on day 3. Skeletal muscle wasting was measured by the mRNA expression of two E3 ubiquitin ligases, muscle atrophy F-box and muscle ring finger 1 as well as 3-methylhistidine (3-MH) and tyrosine release. Three hypothalamic neuropeptides (POMC, AgRP, CART) expression were detected in all groups. POMC expression knockdown was achieved by ARC injection of lentiviruses containing shRNA against POMC. Two weeks after ARC viruses injection, rats were i.p. injected with LPS (10 mg/kg) followed by MLT (30 mg/kg/day) or saline for 3 days. Brain tissues were harvested for immunostaining. In septic rats, 3-MH, tyrosine release and muscle atrophic gene expression were significantly decreased in MLT treated group. POMC and CART expression were lower while AgRP expression was higher in MLT treated group. Furthermore, in septic rats treated with MLT, muscle wasting in those with lower expression of neuropeptide POMC did not differ from those with normal POMC expression. Exogenous MLT could alleviate skeletal muscle wasting in septic rats by regulating hypothalamic neuropeptides.
Isolated Psychiatric Ward Patients in Southern Israel with Severe Mental Illnesses Describe Their Sexual Needs: A Qualitative Study
Authors: Kaplan Michal , Peleg-Sagy Tal , Guez Jonathan , Sagy Iftach 
Published: January 2022

AbstractIntimacy and sexuality are fundamental issues in human nature, but have been neglected in the rehabilitation of mental health patients, particularly those admitted into psychiatric wards. Patients’ sexuality is excluded from the discourse; yet it exists in the daily lives of the patients. The study examines the sexual needs and challenges of people with severe mental illnesses admitted to an isolated psychiatric ward. 13 men were interviewed in a semi-structured interview regarding their sexuality and the challenges they meet when experiencing and expressing their sexuality as patients in an isolated ward. A thematic analysis was conducted. Two principal themes were identified: 1. Challenges in realizing sexuality within the isolated ward. This theme included sub themes: performing sexual acts and exposure to sexuality within the ward; medications' side effects; dialogue with the staff; sexuality in the ward presented as crossing limits; and absence of a space to fulfill sexuality. 2. Suggestions for improvements in the hospital, stemming from the patients' experiences and ideas, such as starting an open dialogue with the staff, supplying patients with measures for protected sex, and more. The findings highlight the lack of healthy expression of sexuality inside the wards, despite its importance for improving patients’ well-being during their rehabilitation. Medical staff and policymakers should be aware of the sexual aspects of hospitalization in a psychiatric ward. The study also indicates the need for national policy that will address patients' sexual needs, including clear instructions that consider the uniqueness of the target population.
Many are the ways to learn identifying multi-modal behavioral profiles of collaborative learning in constructivist activities
Authors: Nasir Jauwairia , Kothiyal Aditi , Bruno Barbara , Dillenbourg Pierre 
Published: January 2022

AbstractUnderstanding the way learners engage with learning technologies, and its relation with their learning, is crucial for motivating design of effective learning interventions. Assessing the learners’ state of engagement, however, is non-trivial. Research suggests that performance is not always a good indicator of learning, especially with open-ended constructivist activities. In this paper, we describe a combined multi-modal learning analytics and interaction analysis method that uses video, audio and log data to identify multi-modal collaborative learning behavioral profiles of 32 dyads as they work on an open-ended task around interactive tabletops with a robot mediator. These profiles, which we name Expressive Explorers, Calm Tinkerers, and Silent Wanderers, confirm previous collaborative learning findings. In particular, the amount of speech interaction and the overlap of speech between a pair of learners are behavior patterns that strongly distinguish between learning and non-learning pairs. Delving deeper, findings suggest that overlapping speech between learners can indicate engagement that is conducive to learning. When we more broadly consider learner affect and actions during the task, we are better able to characterize the range of behavioral profiles exhibited among those who learn. Specifically, we discover two behavioral dimensions along which those who learn vary, namely, problem solving strategy (actions) and emotional expressivity (affect). This finding suggests a relation between problem solving strategy and emotional behavior; one strategy leads to more frustration compared to another. These findings have implications for the design of real-time learning interventions that support productive collaborative learning in open-ended tasks.