bluuebunny/crossref_metadata_2025_split huggingface dataset:
The RAPID3 questionnaire as a screening tool to reduce the number of outpatient clinic visits: a retrospective cohort study
Authors: Wiegel J. , Seppen B. F. , ter Wee M. M. , Nurmohamed M. T. , Boers M. , Bos W. H. 
Published: April 2022

Abstract
Background
Treat-to-target strategies require frequent on-site evaluations of disease activity in patients with rheumatoid arthritis (RA), burdening patients and caregivers. However, this frequency may not be required in patients in a stable low disease activity state. The Routine Assessment of Patient Index Data 3 (RAPID3) is a reliable tool to detect such states in groups but has not been tested to reduce the frequency of on-site evaluations in individual patient care. In Reade, an outpatient rheumatology clinic, patients can complete the questionnaire online prior to consultation, and the results are directly fed into the electronic patient record. Focusing on low disease activity, we retrospectively studied the test characteristics of RAPID3 and its agreement with the DAS28 in our database of routine patient care.

Objective
To assess the test characteristics and agreement between de DAS28 and the RAPID3 in patients with RA, with a focus on the low disease activity categories.

Methods
We performed a retrospective database study with available clinical data collected as part of usual care from the electronic medical record at Reade Amsterdam. The dataset comprised RAPID3 assessments followed by a DAS28 within 2 weeks, obtained between June 2014 and March 2021. We dichotomized the disease activity categories for both the RAPID3 and DAS28 into low (remission and low disease activity) and high (moderate and high disease activity). With cutoff values of 2.0 for RAPID3 and 3.2 for DAS28, we calculated test characteristics and agreement (Cohen’s kappa).

Results
A total of 5009 combined RAPID3 and DAS28 measurements were done at Reade in 1681 unique RA patients. The mean age was 60 years, and 76% of patients were female with a median disease duration of 4 years. Agreement was considered fair (kappa = 0.26). In total, 1426 (28%) of the RAPID3 measurements were classified as low and could be potentially targeted to skip their consultations. The sensitivity to detect low disease activity was 0.39, specificity was 0.93, and the positive predictive value was 0.92.

Conclusion
We showed that when the RAPID3 classifies a patient into low disease activity state, the accuracy is 92%. Of all consultations, 28% could possibly be postponed following the screening with RAPID3.

Key Points• Most studies conclude that the RAPID3 alone is insufficient to monitor the disease activity of RA due to its general overestimation of the disease activity compared with the DAS28.• Our results show that in 92% of the cases patients with a RAPID3 ≤ 2.0 have a DAS28 ≤ 3.2.• We propose a system where the RAPID3 is used to screen for patients in remission/low disease activity, in order to postpone consultations of these patients and reduce the number of unnecessary outpatient clinic visits.
A systematic managerial perspective on the environmentally sustainable construction practices of UK
Authors: Maqbool Rashid , Amaechi Ifeanyi Echezona 
Published: April 2022

AbstractConstruction industry, though is the backbone of any economy, still add a significant portion of emissions, utilising energy supplies, and reasoning in bulk of waste production. The sustainable construction practices are the only solution considering the global climatic challenges. Owing its enormous benefits, a lot of sustainable constructions projects are built around the world, both in developed and developing countries. However, considering the innovative material and technological involvement, and lack of knowledge and expertise, such sustainable construction projects are not always successful. This research aims to investigate the barriers and factors impacting sustainability in the construction projects. More specifically, its primary purpose is to have the perspective of managers on the actors and barriers of sustainable construction in the UK. A mixed method was used to collect the data, one in the mean of questionnaire survey, and the second through the case study. To acquire quantitative data, a snowball sampling was applied to collect the questionnaire survey based data from 128 UK construction managerial positions, such as system managers, sustainability managers, project managers and construction managers, etc. The quantitative acquired data was analysed using mean analysis, relevant importance index (RII), correlation and multiple hierarchical regression. The RII analysis discovered that sustainable construction designs is a top drivers of sustainable construction practices, whereas excessive concentration on price is found as the top impediment of sustainable construction practices. It was also shown by the hierarchical regression analysis that stakeholders factors, project management factors and technological factors significantly impact to sustainable construction practice. However, surprisingly the role of barriers was not observed in the sustainable construction practices of the UK. The same findings were also confirmed with the case study analysis of the Kier Group plc, which believes in the sustainable construction practices. Hence, it is needful for the positive sides of these factors be considered and duly exploited. The research findings provide interesting industrial insights towards sustainable construction projects, while providing useful directions to the industrialists, policymakers and construction professionals, not only by reducing the unfavourable effects, but also by proposing the intention of restoring factors of the environment, economic and social sustainability.
Obesity as a premature aging phenotype — implications for sarcopenic obesity
Authors: Nunan Emily , Wright Carson L. , Semola Oluwayemisi A. , Subramanian Madhan , Balasubramanian Priya , Lovern Pamela C. , Fancher Ibra S. , Butcher Joshua T. 
Published: April 2022

AbstractObesity and aging have both seen dramatic increases in prevalence throughout society. This review seeks to highlight common pathologies that present with obesity, along with the underlying risk factors, that have remarkable similarity to what is observed in the aged. These include skeletal muscle dysfunction (loss of quantity and quality), significant increases in adiposity, systemic alterations to autonomic dysfunction, reduction in nitric oxide bioavailability, increases in oxidant stress and inflammation, dysregulation of glucose homeostasis, and mitochondrial dysfunction. This review is organized by the aforementioned indices and succinctly highlights literature that demonstrates similarities between the aged and obese phenotypes in both human and animal models. As aging is an inevitability and obesity prevalence is unlikely to significantly decrease in the near future, these two phenotypes will ultimately combine as a multidimensional syndrome (a pathology termed sarcopenic obesity). Whether the pre-mature aging indices accompanying obesity are additive or synergistic upon entering aging is not yet well defined, but the goal of this review is to illustrate the potential consequences of a double aged phenotype in sarcopenic obesity. Clinically, the modifiable risk factors could be targeted specifically in obesity to allow for increased health span in the aged and sarcopenic obese populations.
The limitations of bioeconomy LCA studies for understanding the transition to sustainable bioeconomy
Authors: Talwar Nishtha , Holden Nicholas M. 
Published: April 2022

Abstract
Purpose
Transition to bioeconomy requires all actors and stakeholders to measure the impact of systems that use bioresources and technologies to provision society. There are however some challenges with integrating LCA into business development and management, which have important implications for bioeconomy. There have been many LCA studies published in the twenty-first century, but the question must be answered: how useful are these LCA studies to help understand and manage transition to sustainable bioeconomy?

Method
This research used a structured literature review to identify 83 bioeconomy LCA studies published from January 2006 to June 2021 (excluding bioenergy). The studies were analysed for compliance with the ISO 14044 standard, with specific reference to the goal, commissioning perspective, system boundary, function and functional unit, impact methods and categories.

Results and discussions
It was found that more than 85% of the studies reviewed failed to present the required goal statement and a description of the function of the system. Nearly 13% of the studies did not define the system boundary, and only 17% included a full life cycle including raw material extraction, production, use and end-of-life stages. The majority of the LCA studies surveyed from 2006 to 2021 were either (i) not in compliance with the ISO standards or (ii) space and style limitations of the publication process prevented competent practitioners from properly conveying their work. This suggests that the value and integrity of the literature are undermined by not rigorously addressing the first and most important stage of an LCA study.

Conclusion
When interpreting the results, a major shortcoming noted was that most studies did not consider the industrial symbiosis needed between feedstock, technology, primary products, side streams, downstream valorisation and long-term circularity in order to properly understand the transition pathways required. Bioeconomy technologies were imagined as displacers for feedstocks and processes to adapt business as usual, rather than as transformers of the system to a sustainable footing.

Recommendation
If LCA studies are going to provide meaningful information for actors and stakeholders to assess whether a system will be able to operate sustainably, studies should include a full, integrated system, standards should be adhered to and approaches should perhaps go beyond mere eco-efficiency, or doing less harm, as these are not necessarily indicative of sustainability. Historical bioeconomy LCA studies do not provide great insight into the transition to sustainable bioeconomy.
Assessment and Counseling Gaps Among Former Smokers Eligible for Lung Cancer Screening in US Adults
Authors: Hood-Medland Eve Angeline , Dove Melanie S. , Tong Elisa K. 
Published: April 2022

Abstract
Background
Lung cancer screening (LCS) for former and current smokers requires that current smokers are counseled on tobacco treatment. In the USA, over 4 million former smokers are estimated to be eligible for LCS based on self-report for “not smoking now.” Tobacco use and exposure can be measured with the biomarker cotinine, a nicotine metabolite reflecting recent exposure.

Objective
To examine predictors of tobacco use and exposure among self-reported former smokers eligible for LCS.

Design
Cross-sectional study using the 2013–2018 National Health and Nutrition Examination Survey.

Participants
Former smokers eligible for LCS (n = 472).

Main Measures
Recent tobacco use was defined as reported tobacco use in the past 5 days or a cotinine level above the race/ethnic cut points for tobacco use. Recent tobacco exposure was measured among former smokers without recent tobacco use and defined as having a cotinine level above 0.05 ng/mL.

Key Results
One in five former smokers eligible for LCS, totaling 1,416,485 adults, had recent tobacco use (21.4%, 95% confidence interval (CI) 15.8%, 27.0%), with about a third each using cigarettes, e-cigarettes, or other tobacco products. Among former smokers without recent tobacco use, over half (53.0%, 95% CI: 44.6%, 61.4%) had cotinine levels indicating recent tobacco exposure. Certain subgroups had higher percentages for tobacco use or exposure, especially those having quit within the past 3 years or living with a household smoker.

Conclusions
Former smokers eligible for LCS should be asked about recent tobacco use and exposure and considered for cotinine testing. Nearly 1.5 million “former smokers” eligible for LCS may be current tobacco users who have been missed for counseling. The high percentage of “passive smokers” is at least double that of the general nonsmoking population. Counseling about the harms of tobacco use and exposure and resources is needed.
Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent Organic Pollutants (2008–2019)
Authors: Fiedler Heidelore , Sadia Mohammad , Krauss Thomas , Baabish Abeer , Yeung Leo W. Y. 
Published: April 2022

AbstractWithin the global monitoring plan (GMP) established by article 16 of the Stockholm Convention on Persistent Organic Pollutants, perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) are recommended for analysis in core matrices to assess occurrence and changes geographically and with time. In 101 samples consisting of 86 national pools and 15 pools from States in Brazil obtained between 2008 and 2019, PFHxS was detected in 17% of the national pools and none in Brazil. PFOA and PFOS had a detection frequency of 100% and 92%, respectively. Other perfluoroalkane substances (PFAS) had either low detection frequencies and median values of zero (carboxylic acids C4–C11; except PFOA) or could not be quantified in any sample (sulfonic acids, C4–C10, and long-chain carboxylic acids, C12–C14). Correlation between PFOA and PFOS was moderately (r = 0.58). Whereas median values were almost identical (18.9 pg/g f.w. for PFOS; 18.6 pg/g f.w. for PFOA), PFOS showed larger ranges (< 6.2 pg/g f.w.−212 pg/g f.w.) than PFOA (< 6.2 pg/g f.w.−63.4 pg/g f.w.). It was shown that wealthier countries had higher PFOA concentrations than poorer countries. No difference in concentrations was found for samples collected in countries having or not having ratified the Stockholm Convention amendments to list PFOS or PFOA. The goal to achieve 50% decrease in concentrations within ten years was met by Antigua and Barbuda, Kenya, and Nigeria for PFOS and by Antigua and Barbuda for PFOA. In a few cases, increases were observed; one country for PFOS, four countries for PFOA.
Economic Burden of Pancreatic Cancer in Europe: a Literature Review
Authors: Hernandez Diego , Wagner Fabienne , Hernandez-Villafuerte Karla , Schlander Michael 
Published: April 2022

Abstract
Purpose
Pancreatic cancer is characterized by its high mortality, usually attributed to its diagnosis in already advanced stages. This article aims at presenting an overview of the economic burden of pancreatic cancer in Europe.

Methods
A systematic literature review was conducted. It made use of the search engines EconLit, Google Scholar, PubMed and Web of Science, and retrieved articles published after December 31st, 1992, and before April 1st, 2020. Study characteristics and cost information were extracted. Cost per patient and cost per patient per month (PPM) were calculated, and drivers of estimate heterogeneity was analysed. Results were converted into 2019 Euros.

Results
The literature review yielded 26 studies on the economic burden attributable to pancreatic cancer in Europe. Cost per patient was on average 40,357 euros (median 15,991), while figures PPM were on average 3,656 euros (median 1,536). Indirect costs were found to be on average 154,257 euros per patient or 14,568 euros PPM, while direct costs 20,108 euros per patient and 2,004 euros PPM. Nevertheless, variation on cost estimations was large and driven by study methodology, patient sample characteristics, such as type of tumour and cancer stage and cost components included in analyses, such as type of procedure.

Conclusion
Pancreatic cancer direct costs PPM are in the upper bound relative to other cancer types; however, direct per patient costs are likely to be lower because of shorter survival. Indirect costs are substantial, mainly attributed to high mortality.
The organizational side of a disruption mitigation process: exploring a case study during the COVID-19 pandemic
Authors: Molinaro Margherita , Romano Pietro , Sperone Gianluca 
Published: April 2022

Abstract
This paper deals with the mitigation process of the COVID-19 pandemic. Scholars propose and discuss several mitigation strategies to face the COVID-19 disruptions, mainly focusing on technology and supply chain redesign related aspects. Less attention has been paid to the organizational aspects of the mitigation process. We address this gap through an in-depth analysis of the reactive organizational practices implemented by an Italian company during the COVID-19 pandemic. We further compare these practices with those proposed in the disruption management literature to identify common traits and differences. The results show that the overall management of a pandemic’s mitigation process does not significantly differ from that of conventional disruptions, since both contexts require the same basic organizational practices. However, some peculiarities on how these practices should be implemented in a pandemic setting do emerge, such as the implementation of a cyclic rather than linear problem-solving process, the adoption of a learning-by-doing approach, the need of a risk-taker mindset and the importance of creativity and improvisation. Besides complementing the literature, these findings allow to provide indications to managers on how to organize and coordinate the activities during the mitigation process, as well as on what capabilities and competencies should be leveraged to face the pandemic’s disruptions.
Appraisal self-respect: Scale validation and construct implications
Authors: Clucas Claudine , Corr Philip , Wilkinson Heather , Schepman Astrid 
Published: April 2022

AbstractDespite the widely accepted recognition of the notion of self-respect and its importance for emotional well-being, it has received scant attention in the psychological literature. We report on the development and validation of a scale to measure trait (character-based) appraisal self-respect (ASR), conceptualised as a disposition to perceive or appraise oneself as being a respectworthy honourable person. We tested the factor structure, reliability, convergent, discriminant and criterion validity of the ASR scale in samples of adult individuals (combined N = 1910 across samples). The resulting ASR scale was found to be essentially unidimensional and showed good internal and acceptable test-retest reliability. Trait ASR was correlated with (yet distinct from) theoretically related measures of global self-esteem, moral self and principledness, and was distinct from other self-esteem facets not based on honourable character traits. Importantly, it related to well-being and prosocial behaviour over-and-above self-esteem. The validation work served to consolidate the theoretical boundaries and utility of this important concept.
Isoflurane and Sevoflurane Induce Cognitive Impairment in Neonatal Rats by Inhibiting Neural Stem Cell Development Through Microglial Activation, Neuroinflammation, and Suppression of VEGFR2 Signaling Pathway
Authors: Zuo Chunlong , Ma Junmei , Pan Yizhao , Zheng Dongxu , Chen Chunjiang , Ruan Naqi , Su Ying , Nan Haihan , Lian Qingquan , Lin Han 
Published: April 2022

AbstractInhaled anesthetics are known to induce neurotoxicity in the developing brains of rodents, although the mechanisms are not well understood. The aim of this study was to elucidate the molecular mechanisms underlying anesthetics-induced neurodevelopmental toxicity by VEGF receptor 2 (VEGFR2) through the interaction between microglia and neural stem cells (NSCs) in postnatal day 7 (P7) rats. Cognitive function of P7 rats exposed to isoflurane and sevoflurane were assessed using Morris Water Maze and T maze tests. We also evaluated the expression levels of NSC biomarkers (Nestin and Sox2), microglia biomarker (CD11b or or IBA1), pro-inflammatory cytokines (IL-6 and TNF-α), and VEGFR2 using western blotting and immunohistochemistry in the brains of control and anesthesia-treated rats. We found spatial learning and working memory was impaired 2 weeks after anesthetics exposure in rats. Isoflurane induced stronger and more prolonged neurotoxicity than sevoflurane. However, cognitive functions were recovered 6 weeks after anesthesia. Isoflurane and sevoflurane decreased the levels of Nestin, Sox2, and p-VEGFR2, activated microglia, decreased the number of NSCs and reduced neurogenesis and the proliferation of NSCs, and increased the levels of IL-6, TNF-α, and CD11b. Our results suggested that isoflurane and sevoflurane induced cognitive impairment in rats by inhibiting NSC development and neurogenesis via microglial activation, neuroinflammation, and suppression of VEGFR2 signaling pathway.
Deep convolutional forest: a dynamic deep ensemble approach for spam detection in text
Authors: Shaaban Mai A. , Hassan Yasser F. , Guirguis Shawkat K. 
Published: April 2022

AbstractThe increase in people’s use of mobile messaging services has led to the spread of social engineering attacks like phishing, considering that spam text is one of the main factors in the dissemination of phishing attacks to steal sensitive data such as credit cards and passwords. In addition, rumors and incorrect medical information regarding the COVID-19 pandemic are widely shared on social media leading to people’s fear and confusion. Thus, filtering spam content is vital to reduce risks and threats. Previous studies relied on machine learning and deep learning approaches for spam classification, but these approaches have two limitations. Machine learning models require manual feature engineering, whereas deep neural networks require a high computational cost. This paper introduces a dynamic deep ensemble model for spam detection that adjusts its complexity and extracts features automatically. The proposed model utilizes convolutional and pooling layers for feature extraction along with base classifiers such as random forests and extremely randomized trees for classifying texts into spam or legitimate ones. Moreover, the model employs ensemble learning procedures like boosting and bagging. As a result, the model achieved high precision, recall, f1-score and accuracy of 98.38%.
Synthesis of Parallel Software from Heterogeneous Dataflow Models
Authors: Rafique Omair , Schneider Klaus 
Published: April 2022

AbstractDataflow process networks (DPNs) are intrinsically data-driven, i.e., node actions are not synchronized among each other and may fire whenever sufficient input operands arrived at a node. While the general model of computation (MoC) of DPNs does not impose further restrictions, many different subclasses of DPNs representing different dataflow MoCs have been considered over time. These classes mainly differ in the kinds of behaviors of the processes. A DPN may be heterogeneous in that different processes in the network belong to different classes of DPNs. A heterogeneous DPN can therefore be effectively used to model and to implement different components of a system with different kinds of processes and, therefore, different dataflow MoCs. This paper presents a model-based design based on different dataflow MoCs including their heterogeneous combinations. In particular, it covers the automatic software synthesis of systems from DPN models. The main objective is to validate, evaluate and compare the artifacts exhibited by different dataflow MoCs at the implementation level of systems under the supervision of a common design tool. Moreover, this work also offers an efficient synthesis method that targets and exploits heterogeneity in DPNs by generating implementations based on the kinds of behaviors of the processes. The proposed synthesis method provides a tool chain including different specialized code generators for specific dataflow MoCs, and a runtime system that finally maps models using a combination of different dataflow MoCs on cross-vendor target hardware.