bluuebunny/crossref_metadata_2025_split huggingface dataset:
The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network
Authors: Chatzifrangkeskou Maria , Skourides Paris A. 
Published: November 2022

AbstractThe Ciliary Adhesion (CA) complex forms in close association with the basal bodies of cilia during the early stages of ciliogenesis and is responsible for mediating complex interactions with the actin networks of multiciliated cells (MCCs). However, its precise localization with respect to basal body accessory structures and the interactions that lead to its establishment in MCCs are not well understood. Here, we studied the distribution of the CA proteins using super-resolution imaging and possible interactions with the microtubule network. The results of this study reveal that the apical CA complex forms at the distal end of the basal foot and depends on microtubules. Our data also raise the possibility that CAs may have additional roles in the regulation of the organization of the microtubule network of MCCs.
Comparison of open and robotic-assisted partial nephrectomy approaches using multicentric data (UroCCR-47 study)
Authors: Ingels A. , Bensalah K. , Beauval J. B. , Paparel P. , Rouprêt M. , Lang H. , Nouhaud F. X. , Hénon F. , Bruyère F. , Audenet F. , Lebacle C. , Baumert H. , Long J. A. , Tambwe R. , Charles T. , Xylinas E. , Waeckel T. , Michiels C. , Asselineau J. , Bénard A. , Margue G. , Boissier R. , Bigot P. , Bernhard J. C. ,   the Comité Cancer de l’Association Francaise d’Urologie (CCAFU), Gimel P. , Khene Z. , Ouzaid I. , Doumerc N. , Pettenati C. , Cornelis F. , Barthelemy P. , Rioux-Leclercq N. , Albiges L. , Bigot P. 
Published: November 2022

AbstractWe compared the outcomes of robotic-assisted partial nephrectomy (RPN) and open partial nephrectomy (OPN) using contemporary data to respond to unmet clinical needs. Data from patients included in the registry who underwent partial nephrectomy between January 01, 2014 and June 30, 2017 within 20 centres of the French Network for Research on Kidney Cancer UroCCR were collected (NCT03293563). Statistical methods included adjusted multivariable analyses. Rates of peri- and post-operative transfusion, and of surgical revision, were lower in the RPN (n = 1434) than the OPN (n = 571) group (2.9% vs. 6.0%, p = 0.0012; 3.8% vs. 11.5%, p < 0.0001; 2.4% vs. 6.7%, p < 0.0001, respectively). In multivariable analyses, RPN was independently associated with fewer early post-operative complications than OPN (overall: odds-ratio [95% confidence interval, CI] = 0.48 [0.35–0.66]; severe: 0.29 [0.16–0.54], p < 0.0001 for both) and shorter hospital stays (34% [30%; 37%], p < 0.0001). RPN was also a significantly associated with a decresedrisk of post-operative acute renal failure, and new-onset chronic kidney disease at 3 and 12 months post-surgery. There were no between-group differences in oncological outcomes. In comparison with OPN, RPN was associated with improved peri- and post-operative morbidity, better functional outcomes, and shorter hospital stays. Our results support the use of RPN, even for large and complex tumours.
Evidence of the unidimensional structure of mind perception
Authors: Tzelios Kallie , Williams Lisa A. , Omerod John , Bliss-Moreau Eliza 
Published: November 2022

AbstractThe last decade has witnessed intense interest in how people perceive the minds of other entities (humans, non-human animals, and non-living objects and forces) and how this perception impacts behavior. Despite the attention paid to the topic, the psychological structure of mind perception—that is, the underlying properties that account for variance across judgements of entities—is not clear and extant reports conflict in terms of how to understand the structure. In the present research, we evaluated the psychological structure of mind perception by having participants evaluate a wide array of human, non-human animal, and non-animal entities. Using an entirely within-participants design, varied measurement approaches, and data-driven analyses, four studies demonstrated that mind perception is best conceptualized along a single dimension.
High gain low profile horn array with circular polarization using a 3D printed anisotropic dielectric composite material at 38 GHz
Authors: Castro Nelson , Pizarro Francisco , Rajo-Iglesias Eva 
Published: November 2022

AbstractIn this work, the design of a fully 3D-printed dielectric polarizer based on anisotropic engineered material operating at 38 GHz is presented. The anisotropy conditions to obtain circular polarization are achieved by using an array of dielectric strips, manufactured using two different commercially available filaments for 3D-printing. To illuminate the polarizer, a low-profile horn linear array fed by transverse slots is designed and manufactured. The results show good agreement between simulations and measurements, with the designed polarizer covering the whole operation band of the antenna by keeping a similar gain when compared to the structure without the polarizer.
Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly
Authors: Ozawa Junichi , Ohno Seiko , Melgari Dario , Wang Qi , Fukuyama Megumi , Toyoda Futoshi , Makiyama Takeru , Yoshinaga Masao , Suzuki Hiroshi , Saitoh Akihiko , Ai Tomohiko , Horie Minoru 
Published: November 2022

AbstractTimothy syndrome (TS) is a rare pleiotropic disorder associated with long QT syndrome, syndactyly, dysmorphic features, and neurological symptoms. Several variants in exon 8 or 8a of CACNA1C, a gene encoding the α-subunit of voltage-gated Ca2+ channels (Cav1.2), are known to cause classical TS. We identified a p.R412M (exon 9) variant in an atypical TS case. The aim of this study was to examine the functional effects of CACNA1C p.R412M on CaV1.2 in comparison with those of p.G406R. The index patient was a 2-month-old female infant who suffered from a cardio-pulmonary arrest in association with prolonged QT intervals. She showed dysmorphic facial features and developmental delay, but not syndactyly. Interestingly, she also presented recurrent seizures from 4 months. Genetic tests identified a novel heterozygous CACNA1C variant, p.R412M. Using heterologous expression system with HEK-293 cells, analyses with whole-cell patch-clamp technique revealed that p.R412M caused late Ca2+ currents by significantly delaying CaV1.2 channel inactivation, consistent with the underlying mechanisms of classical TS. A novel CACNA1C variant, p.R412M, was found to be associated with atypical TS through the same mechanism as p.G406R, the variant responsible for classical TS.
KLF15 suppresses tumor growth and metastasis in Triple-Negative Breast Cancer by downregulating CCL2 and CCL7
Authors: Kanyomse Quist , Le Xin , Tang Jun , Dai Fengsheng , Mobet Youchaou , Chen Chang , Cheng Zhaobo , Deng Chaoqun , Ning Yijiao , Yu Renjie , Zeng Xiaohua , Xiang Tingxiu 
Published: November 2022

AbstractKruppel like factor 15 (KLF15), a transcriptional factor belonging to the Kruppel-like factor (KLF) family of genes, has recently been reported as a tumor suppressor gene in breast cancer. However, the specific mechanisms by which KLF15 inhibits BrCa have not been elucidated. Here we investigated the role and mechanism of KLF15 in triple-negative breast cancer (TNBC). KLF15 expression and methylation were detected by RT-qPCR, RT-PCR and methylation-specific PCR in breast cancer cell lines and tissues. The effects of KLF15 on TNBC cell functions were examined via various cellular function assays. The specific anti-tumor mechanisms of KLF15 were further investigated by RNA sequence, RT-qPCR, Western blotting, luciferase assay, ChIP, and bioinformatics analysis. As the results showed that KLF15 is significantly downregulated in breast cancer cell lines and tissues, which promoter methylation of KLF15 partially contributes to. Exogenous expression of KLF15 induced apoptosis and G2/M phase cell cycle arrest, suppressed cell proliferation, metastasis and in vivo tumorigenesis of TNBC cells. Mechanism studies revealed that KLF15 targeted and downregulated C–C motif chemokine ligand 2 (CCL2) and CCL7. Moreover, transcriptome and metabolome analysis revealed that KLF15 is involved in key anti-tumor regulatory and metabolic pathways in TNBC. In conclusion, KLF15 suppresses cell growth and metastasis in TNBC by downregulating CCL2 and CCL7. KLF15 may be a prognostic biomarker in TNBC.
Reliable reference genes and abiotic stress marker genes in Klebsormidium nitens
Authors: Chatelain Pauline , Blanchard Cécile , Astier Jeremy , Klinguer Agnès , Wendehenne David , Jeandroz Sylvain , Rosnoblet Claire 
Published: November 2022

AbstractMicroalgae have recently emerged as a key research topic, especially as biological models. Among them, the green alga Klebsormidium nitens, thanks to its particular adaptation to environmental stresses, represents an interesting photosynthetic eukaryote for studying the transition stages leading to the colonization of terrestrial life. The tolerance to different stresses is manifested by changes in gene expression, which can be monitored by quantifying the amounts of transcripts by RT-qPCR. The identification of optimal reference genes for experiment normalization was therefore necessary. In this study, using four statistical algorithms followed by the RankAggreg package, we determined the best reference gene pairs suitable for normalizing RT-qPCR data in K. nitens in response to three abiotic stresses: high salinity, PEG-induced dehydration and heat shock. Based on these reference genes, we were able to identify marker genes in response to the three abiotic stresses in K. nitens.
Multivariate indium–organic frameworks for highly efficient carbon dioxide capture and electrocatalytic conversion
Authors: Wang Shuo , Wang Ying , Huo Jia-Min , Yuan Wen-Yu , Zhang Peng , Li Shu-Ni , Zhai Quan-Guo 
Published: November 2022

A series of trinuclear indium–organic frameworks was synthesized and this work demonstrates that bimetallic engineering is a promising strategy for efficient CO2 capture and electrocatalytic CO2 conversion.
An embedded intrusion detection and prevention system for home area networks in advanced metering infrastructure
Authors: Qaddoori Sahar Lazim , Ali Qutaiba Ibrahim 
Published: November 2022

AbstractWith the widespread adoption of smart metres in the power sector, anomaly detection has become a critical tool for analysing customers' unusual consumption patterns and network traffic. Detecting anomalies in power consumption and communication is primarily a real‐time big data analytics issue regarding data mining along with a vast number of parallel streaming data from smart metres. In this study, an embedded Intrusion Detection and Prevention System (IDPS) is proposed as a Wifi‐based smart metre for Home Area Networks (HANs) in the Advanced Metering Infrastructure (AMI) network. So, the proposed system employs one machine learning model based on IDPS to guard the HAN network from various attacks that utilise the Message Queueing Telemetry Transport protocol between the smart metre and IoT sensors. Also, it uses two machine learning models to detect the abnormality in periodic and daily data metering respectively. So, multiple algorithms have been used to find the suitable algorithm for each of the three anomaly detection models. These models have been evaluated and tested using real data sets regarding resources usage and detection performance to demonstrate the efficiency and effectiveness of using machine learning algorithms in the built anomaly detection models. The experiments show that the anomaly detection models performed well for various abnormalities.
Randomly Flipped Chip based signal power authentication for GNSS civilian signals
Authors: Muzi Yuan , Xiaomei Tang , Pengyue Sun , Yangbo Huang , Gang Ou 
Published: November 2022

AbstractThe navigation signal authentication schemes protect GNSS services from spoofing attacks by attaching unforgeable information to signals. In this study, Randomly Flipped Chip based Signal Power Authentication (RFC‐SPA), is proposed to jointly authenticate the navigation message and spreading code of GNSS civilian signals. Designed to support two modes of authentication (fast channel and slow channel), the proposed scheme employs a fixed amount of flipped chips, which are randomly distributed in some areas of the spreading code to form a relative fluctuation in the correlation result of the signal. The fast channel is a spreading code authentication (SCA) of these flipped chips, which is the same as the Chimera. In the slow channel, since the correlation results between the local periodical spreading code and the signal in areas with flipped chips will be smaller than those results in areas without flipped chips, receivers in the tracking correlation can extract this fluctuation. Since the fluctuation modulates a digital signature, receivers can verify the authenticity of both the navigation message and spreading code through the authentication of this digital signature. Compared with mainstream schemes, RFC‐SPA requires no extra tracking channel and has no impact on the navigation message. Besides, the proposed scheme maintains a similar robustness and security performance while significantly reducing the storage requirement compared with SCA. The scheme is demonstrated in a proposed implementation for Beidou B1C civilian signal, and the performance metrics are analysed. In the proposed implementation, the detection possibility is higher than 99.7% at 35dBHz of C/N0, and only 33.6% of the storage is required compared with the suggested configuration of the Chimera scheme for the GPS L1C civilian signal.
Li-rich and super Li-rich giants produced by element diffusion
Authors: Gao Jun , Zhu Chunhua , Yu Jinlong , Liu Helei , Lu Xizhen , Shi Jianrong , Lü Guoliang 
Published: November 2022

Context.About 0.2−2% of giant stars are Li rich, that is to say their lithium abundance (A(Li)) is higher than 1.5 dex. Nearly 6% of these Li-rich giant stars are super Li rich, with an A(Li) exceeding 3.2 dex. Meanwhile, the formation mechanism of these Li-rich and super Li-rich giants is still under debate.Aims.Considering the compact He core of red giants, attention is paid to the effect of element diffusion on A(Li). In particular, when the He-core flash occurs, element diffusion makes the thermohaline mixing zone extend inward and connect to the inner convection region of stars. Then, a large amount of7Be produced by the He flash can be transferred to the stellar surface, finally turning into7Li. Thus, the goal of this work is to propose the mechanism of A(Li) enrichment and achieve consistency between the theoretical and observation data.Methods.Using the Modules for Experiments in Stellar Astrophysics (MESA) stellar evolution code, we simulated the evolution of low-mass stars, considering the effects of element diffusion on the Li abundances. The timescale ratio of Li-rich giants to normal giants was estimated using the population synthesis method. Then we obtained the theoretical value of A(Li) and made a comparison with observations.Results.Considering the influence of element diffusion in the model results in the increase of the lithium abundance up to about 1.8 dex, which can reveal Li-rich giants. Simultaneously, introducing high constant diffusive mixing coefficients (Dmix) with the values from 1011to 1015cm2s−1in the model allows the A(Li) to increase from 2.4 to 4.5 dex, which can explain most of the Li-rich and super Li-rich giant stars. The population synthesis method reveals that the amount of Li-rich giants is about 0.2−2% of all giants, which is consistent with observation estimated levels.Conclusions.In our models the element diffusion, mainly triggered by the gravity field, changes the mean molecular weight at the junction zone between the stellar envelope and the He core, which makes the thermohaline mixing region expand to the inner convection region of stars. A transport channel, efficiently transporting7Be in the hydrogen-burning region of the star to the convective envelope where7Be decays into7Li, is formed. Combining high constant diffusive mixing coefficients, the transport channel can explain the origin of Li-rich and super Li-rich giants, even the most super Li-rich giants.
How to create Sgr A East
Authors: Ehlerová S. , Palouš J. , Morris M. R. , Wünsch R. , Barna B. , Vermot P. 
Published: November 2022

Context. Sgr A East is the supernova remnant closest to the centre of the Milky Way. Its age has been estimated to be either very young, around 1–2 kyr, or about 10 kyr, and its exact origin remains unclear.
Aims. We aspire to create a simple model of a supernova explosion that reproduces the shape, size, and location of Sgr A East.
Methods. Using a simplified hydrodynamical code, we simulated the evolution of a supernova remnant in the medium around the Galactic centre. The latter consists of a nearby massive molecular cloud with which Sgr A East is known to be interacting and a wind from the nuclear star cluster.
Results. Our preferred models of the Sgr A East remnant are compatible with an age of around 10 kyr. We also find suitable solutions for older ages, but not for ages younger than 5 kyr. Our simulations predict that the supernova exploded at a distance of about 3.5 pc from the Galactic centre, below the Galactic plane, slightly eastwards from the centre and 3 pc behind it.
Fix-and-optimize metaheuristics for minmax regret binary integer programming problems under interval uncertainty
Authors: Carvalho Iago A. , Noronha Thiago F. , Duhamel Christophe 
Published: November 2022

The Binary Integer Programming problem (BIP) is a mathematical optimization problem, with linear objective function and constraints, on which the domain of all variables is {0, 1}. In BIP, every variable is associated with a determined cost coefficient. The Minmax regret Binary Integer Programming problem under interval uncertainty (M-BIP) is a generalization of BIP in which the cost coefficient associated to the variables is not known in advance, but are assumed to be bounded by an interval. The objective of M-BIP is to find a solution that possesses the minimum maximum regret among all possible solutions for the problem. In this paper, we show that the decision version of M-BIP is Σp2-complete. Furthermore, we tackle M-BIP by both exact and heuristic algorithms. We extend three exact algorithms from the literature to M-BIP and propose two fix-and-optimize heuristic algorithms. Computational experiments, performed on the Minmax regret Weighted Set Covering problem under Interval Uncertainties (M-WSCP) as a test case, indicates that one of the exact algorithms outperforms the others. Furthermore, it shows that the proposed fix-and-optimize heuristics, that can be easily employed to solve any minmax regret optimization problem under interval uncertainty, are competitive with ad-hoc algorithms for the M-WSCP.
Breakdown strength of glycerin in helical transmission line under hundred-nanosecond pulse
Authors: Chen Chaoran , Yang Jianhua , Cheng Xinbing , Chen Rong , Geng Jiuyuan , Yue Yunrui 
Published: November 2022

In this paper, a transmission line with five spiral-wires in parallel was designed. The transit time and the characteristic impedance of the transmission line are 200 ns and 14 Ω, respectively. Its slow wave coefficient is close to 13. The insulating medium of the transmission line is glycerin. In order to investigate the breakdown strength of glycerin under a hundred-nanosecond pulse, simulations and experiments are conducted. The results indicate that the breakdown strength of glycerin under hundred nanoseconds reached 653 kV/cm, which is a 400 kV/cm increase compared with that under a microsecond pulse. However, under hundred nanoseconds, the breakdown strength of glycerin in transmission is unaffected by pressure within 1 MPa, and pressure is conducive to the insulation recovery of glycerin.
Morphological, optical, and electrical properties of RF-sputtered zinc telluride thin films for electronic and optoelectronic applications
Authors: Panaitescu Ana-Maria , Antohe Iulia , Răduță Ana-Maria , Iftimie Sorina , Antohe Ștefan , Mihăilescu Cristian Nicolae , Antohe Vlad-Andrei 
Published: November 2022

Zinc telluride (ZnTe) thin films were deposited by radio-frequency magnetron sputtering (RF-MS) onto optical glass coated by a silver–copper (Ag:Cu) thin film representing the back-electrode, and they were subsequently electrically contacted with an aluminum (Al) layer acting as the top-electrode. The RF-MS procedure was carried out at 50 W in argon (Ar) gas atmosphere kept at 2.5 × 10−3 mbar working pressure for 75 min at a substrate temperature of 220 °C kept constant during deposition. Morphological investigations by scanning electron microscopy allowed a first evaluation of the ZnTe film’s thickness. Optical characterization was then performed via absorption and transmission measurements in the spectral range between 300 and 1500 nm at room temperature. Subsequently, the thickness and bandgap energy of the ZnTe thin film were evaluated to be ∼508 nm and ∼2.13 eV, respectively. Moreover, they revealed high transmittance in infrared and near infrared regions of the electromagnetic spectrum. Then, the electrical measurements of Ag:Cu/ZnTe/Al “sandwich” structure (current–voltage characteristics) at six temperatures ranging from 303 to 354 K were performed, allowing the identification of the charge transport mechanisms through the structure along with their corresponding parameters. Based on the excellent optical and electrical properties, these ZnTe thin films show great potential as candidates for performant small-wavelength photodetectors.
The effects of methanol clustering on methanol–water nucleation
Authors: Sun Tong , Wilemski Gerald , Hale Barbara N. , Wyslouzil Barbara E. 
Published: November 2022

The formation of subcritical methanol clusters in the vapor phase is known to complicate the analysis of nucleation measurements. Here, we investigate how this process affects the onset of binary nucleation as dilute water–methanol mixtures in nitrogen carrier gas expand in a supersonic nozzle. These are the first reported data for water–methanol nucleation in an expansion device. We start by extending an older monomer–dimer–tetramer equilibrium model to include larger clusters, relying on Helmholtz free energy differences derived from Monte Carlo simulations. The model is validated against the pressure/temperature measurements of Laksmono et al. [Phys. Chem. Chem. Phys. 13, 5855 (2011)] for dilute methanol–nitrogen mixtures expanding in a supersonic flow prior to the appearance of liquid droplets. These data are well fit when the maximum cluster size imax is 6–12. The extended equilibrium model is then used to analyze the current data. On the addition of small amounts of water, heat release prior to particle formation is essentially unchanged from that for pure methanol, but liquid formation proceeds at much higher temperatures. Once water comprises more than ∼24 mol % of the condensable vapor, droplet formation begins at temperatures too high for heat release from subcritical cluster formation to perturb the flow. Comparing the experimental results to binary nucleation theory is challenged by the need to extrapolate data to the subcooled region and by the inapplicability of explicit cluster models that require a minimum of 12 molecules in the critical cluster.