bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Controlled Analgesia and an Alternative Protocol: A Comparison of Outcomes After Thoracic and Lumbar Surgery
Authors: Donelson Will , Dean Joey , Ablah Elizabeth , Berg Gina , McCormick Kyle , Okut Hayrettin , Whitaker Camden 
Published: July 2022

Introduction. Patient controlled analgesia (PCA) is a common form of pain management after spine surgeries, in which patients get custom control of their opioid dose. PCA has been demonstrated as a safe form of analgesia; however, use of PCA comes with risks that can be mitigated by opting for alternative pain management. This study aimed to compare the outcomes of patients using PCA to those with an alternative analgesia protocol that does not involve PCA.
Methods. A retrospective chart review from January 2017 to July 2018 was conducted. Patients included in this study were those 18 or older who were admitted to a large midwestern tertiary medical center in Wichita, Kansas, and underwent thoracic or lumbar spinal surgery from a single spine surgeon. Data from patient demographics, comorbidities, and type of procedure were collected and compared to control for possible confounding variables. Patients were divided into two groups: patients receiving a PCA pain protocol postoperatively and those receiving a non-PCA protocol. Statistical analyses were performed and all tests with p < 0.05 were considered significant.
Results. This study found patients in the PCA protocol had similar outcomes to those in the alternative analgesia protocol. This was true for both primary and secondary outcomes. The primary outcome was patient length of stay after the operation. Secondary outcomes included readmission rates, frequency of naloxone rescue, transfers to higher levels of care, and total opioid consumption.
Conclusions. This study supports that a non-PCA protocol for postoperative pain management yields similar outcomes to a PCA protocol in the setting of thoracic and lumbar surgery.
La intimidad conectada
Authors: Zafra Remedios 
Published: July 2022

La cultura red ha dado lugar a nuevas formulaciones respecto a la intimidad y su transformación de los ámbitos de poder y relación. Los repliegues de la vida pública y privada que la configuran presentan lecturas ambivalentes si se hace referencia a la vida conectada y a la construcción ciudadana y subjetiva.
Frente a la crítica hacia Internet como motor de exposición y mercantilización del sujeto, el feminismo ha logrado hacerse con la red para visibilizar y compartir lo privado desde una intencionalidad política. Este artículo pretende abordar algunas de las potencias y riesgos del feminismo en Internet como esfera público-privada donde se negocian nuevas formas de crear intimidad y ciudadanía.
Behavioural and cognitive changes in a patient with leukoencephalopathy due to lymphomatosis cerebri
Authors: Crema Santiago , Ricciardi Mario , Calandri Ismael L. 
Published: July 2022

A 59 years old female with a prior history of facial hemangioma, with a three-month progressive cognitive impairment (MoCA score 15/30) combined with abulia, unmotivated crying, non-fluent language, limb paratonia, bilateral Hoffman and palmomental reflex; and apraxic gait.
Inversión empresarial durante la pandemia en Colombia 2020-2021
Authors: Gómez-Mejía Alberto 
Published: July 2022

Aplicando modelos Tobit, se evidencia que durante el período de la pandemia, marzo 2020-septiembre 2021, el comportamiento de la inversión y desarrollo (no digital) en 59 sectores empresariales colombianos, estuvo principalmente determinado por siete variables: positivamente por la inversión en soluciones digitales, aumento del personal trabajando en casa, la disminución del flujo de efectivo empresarial, por el contrario, la inversión fue afectada negativamente por la reducción en los medios de pago (liquidez) y el difícil acceso a los servicios financieros (escasez de crédito), los gastos en bienes y procesos nuevos y mejorados y la esperanza dada por las políticas de apoyo gubernamental. Es importante notar que las expectativas sobre el comportamiento de la economía colombiana en el año siguiente no fueron significativas. El grado del impacto del covid19 fue diferencial entre los sectores intensivos en tecnología y mano de obra no calificada.
Reconstruction Using a Fibular Autograft for Lumbosacral Spinal Deformity in Neurofibromatosis Type 1
Authors: Kawamura Ichiro , Yamamoto Takuya , Tominaga Hiroyuki , Tokumoto Hiroto , Sanada Masato , Taniguchi Noboru 
Published: July 2022

Cases:
We present 2 cases (19- and 40-year-old women) of lumbosacral spinal deformity with sacroiliac joint destruction. Reconstruction surgery using a fibular strut autograft was performed in both patients, and spinal reconstruction and fusion were successfully maintained without bone resorption for at least 7 years.

Conclusion:
This is the first report of reconstructive surgery using a fibular strut bone graft for lumbosacral deformity with destruction of the sacroiliac joint in patients with neurofibromatosis type 1 (NF-1). These findings suggest that reconstruction with a fibular strut autograft is useful for lumbosacral spinal deformity that includes destruction of the sacroiliac joints in NF-1.
Recurrent Cervical Subdural Bleeding Because of Atlantoaxial Instability in a Patient with Rheumatoid Arthritis
Authors: Esteller Gauxax Diana , Doncel-Moriano Antonio , Martínez-Anda Jaime Jesús , Cervera Ricard , Llull Laura , Combalia Andrés 
Published: July 2022

Case:
Atlantoaxial instability (AAI) is a frequent complication of rheumatoid arthritis (RA), but its involvement in intracranial bleeding is unclear. We present a young woman with history of systemic lupus erythematosus and RA who developed 3 episodes of subdural bleeding at the upper cervical spine and cranial level. Imaging tests showed signs of AAI with odontoid deformity. The case was interpreted as recurrent traumatic cervical subdural hemorrhage because of AAI. No new episodes occurred after surgical C1-C2 fixation.

Conclusion:
We report a case that had the association of hemorrhage and C1-2 instability in a patient with RA and lupus erythematosus.
Healing of a Large Bone Defect Secondary to Tuberculosis in an Infant
Authors: Shah Rahul Hemant , Gandbhir Viraj N. , Gujar Harshad 
Published: July 2022

Case:
A 9-month-old male child presented with swelling over the distal radius that was debrided, and histopathology revealed tuberculosis. Curettage left a large bony defect in the distal radius metaphysis. The defect was not surgically addressed because near-complete spontaneous filling of the defect was seen at 3 months' follow-up. The patient was given antituberculous therapy for 12 months and had excellent outcomes at 24 months' follow-up.

Conclusion:
A large bony defect secondary to tuberculosis, in the distal radius metaphysis in an infant, regenerated spontaneously without the need for bone substitutes, bone grafting, or complex microvascular procedures.
Minimising Young Children’s Anxiety through Schools (MY-CATS): Statistical Analysis Plan for a Cluster Randomised Controlled Trial to evaluate the effectiveness and cost-effectiveness of an online parent-led intervention compared with usual school practice for young children identified as at-risk for anxiety disorders
Authors: Jones Benjamin Gary , Reardon Tessa , Creswell Cathy , Dodd Helen F , Hill Claire , Jasper Bec , Lawrence Peter J , Morgan Fran , Rapee Ronald M , Violato Mara , Placzek Anna , Ukoumunne Obioha C 
Published: July 2022

Abstract
BackgroundThe Minimising Young Children’s Anxiety through Schools (MY-CATS) trial is being conducted to determine whether an online evidence-based parent-guided Cognitive Behavioural Therapy intervention in addition to usual school practice is effective and cost-effective compared with usual school practice in reducing anxiety disorders in children aged 4-7 deemed ‘at risk’ of anxiety disorders. This update article describes the detailed statistical analysis plan for the MY-CATS trial and reports a review of the underpinning sample size assumptions.Methods and DesignThe MY-CATS study is a two-arm, definitive superiority pragmatic parallel group cluster randomised controlled trial in which schools will be randomised 1:1 to receive either the intervention (in addition to usual school practice) or usual school practice only. This update to the (published) protocol provides a detailed description of the study methods, the statistical principles, the trial population and the planned statistical analyses, including additional analyses comprising instrumental variable regression and mediation analysis.Trial Registration: ISRCTN 82398107. Prospectively registered on 14.1.2021. https://www.isrctn.com/ISRCTN82398107
Comparison of high-flow nasal cannula and conventional oxygen therapy for high-risk patients during bronchoscopy examination: protocol for a randomized controlled trial
Authors: qin hao , Jing Guo-Qiang , Tan Wei , Wang Jun , Yin Yi-Nan , Chen Rong-Zhang , Zhang Wei , Li Jie 
Published: July 2022

Abstract
IntroductionHigh-flow nasal cannula (HFNC) has been proven to improve oxygenation and avoid intubation in hypoxemic patients. It has also been utilized during endoscopy examination to reduce the incidence of hypoxia. However, little is known about the effects of HFNC versus conventional oxygen therapy (COT) on oxygenation during bronchoscopy examination via nasal route; particularly, no study has compared the use of HFNC with that of COT at similar FIO2 during bronchoscopy examination for patients who have high-risk factors of desaturation during bronchoscopy examination. Methods and analysisThis randomized controlled trial will be implemented in four centers. Patients who have high-risk factors including hypoxemia, hypercapnia, morbid obesity, and narrow airway will be enrolled to use HFNC or COT during bronchoscopy examination. In the HFNC group, the gas flow will be set at the maximal level that the patient can tolerate with a fraction of inspired oxygen (FIO2) at 0.45, with one prong of the nasal cannula occluded and left outside the nose; while in the COT group, oxygen flow will be set at 6 L/min via a single-prong nasal cannula. After 5 min pre-oxygenation, the bronchoscope will be inserted via nasal route. Vital signs, oxygenation (SpO2), and transcutaneous CO2 (PtCO2) will be continuously monitored. Incidence of hypoxemia, defined as SpO2 < 90% for 10 seconds during bronchoscopy examination, and the need for treatment escalation will be compared in the two groups. DiscussionHypoxia is a common complication of bronchoscopy, our study attempted to demonstrate that HFNC may reduce the probability of hypoxia during bronchoscopy in high-risk patients. The results will be disseminated through peer-reviewed journals, national and international conferences.Trial registration http://www.chictr.org.cn/: ChiCTR2100055038. Registered on 31 December 2021URL of the trial registry record：http://www.chictr.org.cn/showproj.aspx?proj=146692
Landslide susceptibility prediction mapping with advanced ensemble models: Son La province, Vietnam
Authors: Bui QUYNH , Ha Hang , Thanh Dong Khuc , Nguyen Dinh Quoc , von Meding Jason , Nguyen Lam Phuong , Luu Chinh 
Published: July 2022

Abstract
Landslides are a serious geohazard in many mountainous areas of Vietnam during the rainy season. They directly threaten human lives and properties every year. Landslide susceptibility maps are useful tools for risk mitigation, land-use planning, and early warning systems for local areas. It is necessary to update these maps continuously because of the complexity of landslide events. This fact requires further extending the approach techniques with practical implications. Therefore, this study aimed to develop landslide susceptibility prediction maps based on advanced Machine Learning (ML) techniques. Five state-of-art hybrid ML models were developed: Bagging – MLP, Dagging – MLP, Decorate – MLP, Rotation Forest – MLP, Random SubSpace – MLP with Multi-Layer Perceptron (MLP) as a base classifier. Sixteen causative factors were collected to build landslide susceptibility maps based on the relationship between historical landslide locations and specific local geo-environmental conditions. The model performance was verified using various statistical indexes. Based on the Area Under ROC curve (AUC) analysis results of the testing dataset, the Rotation Forest – MLP model has the greatest predictive accuracy of AUC = 0.818. It is followed by the Decorate – MLP and Bagging – MLP (AUC=0.804), the Random SubSpace – MLP model (AUC=0.796), the Dagging – MLP (AUC=0.789), and the single MLP (AUC=0.698). The results of this study can be applied effectively to other mountainous regions to mitigate the risk of landslides.
A Study on the Financial Literacy and its Impact on Financial Inclusion (With reference to Undergraduate Students in Hyderabad City)
Authors: B Balanagalakshmi , Kumari Sukhavasi Santha , I Shyam Sundar 
Published: July 2022

Abstract
Financial inclusion is an essential concept of finance that creates numerous financial products and services easy to get to and reasonable to all people and businesses, specifically those excluded from the formal financial arrangement. Financial literacy is the main and fundamental factor that affects ability of people to access financial services. This study explored the impacts of financial literacy on financial access over and done with banking access and fin tech using the data collected from questionnaire through undergraduate students in Hyderabad city. Researcher has employed regression model to scrutinize whether financial literacy significantly affects financial accessibility for the undergraduate students. The experiential findings exhibited that knowledge regarding various financial services factors had significant impacts on getting financial access. Variables such as age, income level of parents, knowledge regarding depositing and withdrawing money, and knowledge regarding interest rate, FT account, FT training, FT bill pay, FT software use etc. affected the overall access to finance.
Glucose levels are not the same for everyone: A real-world big data study evaluating glucose levels by sex and age among children
Authors: Ziv Carmit Avnon , Banon Tamar , Tov Amir Ben , Chodick Gabriel , Gabay Linoy , Auerbach Adi , Hirsch Harry J. , Khademi Floris Levy 
Published: July 2022

Abstract
Purpose: Understanding the normal range of laboratory values as pertained to different age groups and males or females is paramount in health care delivery. We aimed to assess the distribution of glucose levels by age and sex in the general population of children using a large-scale population-based cohort.Methods: A retrospective study with real-world de-identified data from a large, state mandated health fund in Israel among children aged 2 to 18 years old between 2006 and 2019. Age, sex, and BMI differences in mean glucose levels were evaluated using 3-way Anova.Results: Study included 130,170 blood samples from 117,411 children, 53.3% were female. After adjusting for age boys had higher glucose levels than girls, with a mean of 89.21 ±8.66 mg/dL vs. 87.59 ±8.35 (p<0.001). Compared to the 15 to 18 year-olds (88.49 mg/dl ±7.63), 2 to 5 year-olds had lower glucose levels (84.19 ±10.65, (p<0.001)), 11 to 14 year-olds had higher glucose (90.40 ±7.42 (p<0.001)) and 6 to 10 year-olds showed no difference (88.45 ±8.25). Among our cohort, 33.0% (n=42,991) had a BMI percentile record the same year as their glucose test result. There was a weak yet significant positive association between blood glucose levels and BMI (Pearson coefficient <0.1).Conclusions: Our large cohort indicates that boys have higher glucose levels than girls, as do adolescents compared to younger children. This finding is important for the delivery of adequate health care, screening for illness and avoiding unnecessary investigations and tests.
Serum cholesterol-riched apolipoprotein-B (apoB) containing lipoproteins predict the response to immune checkpoints inhibitors (ICIs) in non-small cell lung cancer (NSCLC) : A retrospective analysis
Authors: Hu Zixin , Zheng Yumin , Zheng Jiabin , Wang Yan , Liao Jiangquan , Lu Xingyu , Yu Yixuan , Liu Zhening , Li Jia , Dong Huijing , Cui Huijuan 
Published: July 2022

Abstract
Objectives: Lipid metabolism alternations reprogrammed tumor microenvironment (TME) to influence the response to immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC). Body mass index (BMI) and apolipoproteins B (apoB) including low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) reflect the lipid metabolism status. The associations between BMI, lipoproteins, and clinical outcome of ICIs are far from clear. Methods: A retrospective case-control analysis of 99 NSCLC patients treated with chemotherapy plus ICIs regimens in the department of oncology and lung cancer center of China-Japan Friendship Hospital was performed. The prognostic value of the BMI, serum lipids, lipoproteins, and apolipoproteins were assessed. Efﬁcacy was evaluated by the ICIs response (durable clinical beneﬁt [DCB] / non-durable benefit [NDB]), best response (active/ non-active) and progression-free survival (PFS). The validation test and the mechanism exploration were performed with public data using bioinformatic methods. Results: BMI ≥ 25 kg/m2 was a risk indicator for NDB, non-active response to ICIs, shorter PFS with the confounders adjusted (OR= 6.06, 95% CI 2.05 - 19.89, p.val = 0.002; OR = 4.37, 95% CI 1.64 - 12.43, p.val = 0.004; HR = 3.08, 95% CI 1.63 - 5.82, p.val < 0.001). High apoB containing lipoproteins were risk factors for poor ICIs response. Low RC predicted the better ICIs response and the best response with the satisfied discriminative ability and the well-fitting calibration curves (OR = 0.12, 95%CI 0.02 - 0.63, p.val = 0.017; OR = 0.22. 95%CI 0.05 - 0.96, p.val = 0.047). Serum LDL-C predicted the longer PFS of ICIs with the added value to the BMI containing model (HR = 0.43, 95%CI 0.22 - 0.86, p.val = 0.016). Bioinformatic exploration showed that the LUAD samples with high APOB were infiltrated by elevated fibroblasts and other immune-suppressive cells. Functional enrichment analysis indicated that the acquired ICIs resistance might be through the LRP6/5-Wnt-TGF-β axis which required laboratory experiments to verify. Conclusions: BMI ≥ 25 kg/m2, the elevated apoB containing lipoproteins indicated poor response to the combination of chemotherapy and ICIs in the in the NSCLC population. Further large-scale validations and experimental explorations are needed.
Time distance effect of damming on the degree of hydrological and ecological alteration in floodplain river and wetland
Authors: Pal Swades , Khatun Rumki , SARDA RAJESH , Debanshi Sandipta 
Published: July 2022

Abstract
Usually, the effects of any episodic incident minimize overtime. The time distance effect of hydrological alteration in the river on the ecological condition of a river and the hydrological and ecological conditions of the riparian wetland was examined in this present study. For doing this, an investigation of the degree of hydrological alteration in the river and at 30 × 30m pixel scale water richness (WWR) mapping using weighted overlaying was carried out along with assessing its degree of alteration. Periodicity of river flow at season scale was performed following wavelet transform model. Similarly, the degree of ecological alteration was measured using the range of variability approach (RVA), and flow duration curve (FDC) in three phases (pre-dam (up to 1992), post-dam phase 1 (1993–2012), and phase 2 (2013–2020). From the analysis, it was revealed that after damming, the monthly flow failure rate ranged from 70 to 96%. Eco-deficit in the river was aggravated to some extent with increasing time distance. As a consequence of this, wetland water richness maps of different phases exhibited continuous wetland loss from the poor WWR parts and continued degradation of WWR in post-dam phases. Eco-deficit condition of the wetland was also weakened in post-dam phase 1 and it was continued in the next phase. So, this study clarified that time distance minimizing the effect of damming on rivers and wetlands was not found rather its trend was like a positive feedback mechanism, the wave of impact radiated after damming has been continuing. The study output would be instrumental for river and wetland management and precautions on manmade hydrological modification. The study recommends carrying out similar works with more post-dam length to establish a reliable theory in this regard.
How does the North Pacific Oscillation affect tropical variability? Part II: Intermodel diversity in the NPO-ENSO relationship
Authors: Kug Jong-Seong , Zhao Jiuwei , Park Jae-Heung , Sung Mi-Kyung , Luo Jing-Jia 
Published: July 2022

Abstract
The North Pacific Oscillation (NPO), a primary atmospheric variability over the midlatitude, is a well-known trigger for ENSO events. Based on observational analyses, it has been suggested that the NPO-related wave activity flux (WAF) could directly induce the equatorial wind anomalies in both upper and lower levels. In this study, we further substantiate the impacts of the WAF on tropical circulations using climate models participating in the Coupled Model Intercomparison Project phases 5 and 6 (CMIP5/6). We found that the intensity of the southward WAF over the central Pacific is closely related to the simulated NPO–ENSO relation in the inter-model space. By classifying the models into two groups of strong and weak meridional WAF (MWAF), we reveal that the strong MWAF models simulate stronger upper- and lower-level equatorial winds and precipitation anomalies that facilitate the ENSO in subsequent winter. In addition, we demonstrate that the magnitude of the MWAF is closely related to the model’s climatological meridional wind and meridional shear of climatological zonal wind, emphasizing the role of systematic bias on the ENSO simulation.
Efficacy and safety of mucous fistula refeeding in preterm infants: An exploratory randomized controlled trial
Authors: Lee Eun Sun , Kim Ee-Kyung , Shin Seung Han , Jung Young Hwa , Song In-Gyu , Kim Yoo-Jin , Kim Hyun Young , Choi Young-Hun , Moon Kyung Chul , Kim Bohyun 
Published: July 2022

Abstract
Background: This study aimed to evaluate whether mucous fistula refeeding (MFR) is safe and beneficial for the growth and intestinal adaptation of preterm infants with enterostomies.Methods: This exploratory randomized controlled trial enrolled infants born before 35 weeks’ gestation with enterostomy. If the stomal output was ≥ 40 mL/kg/day, infants were assigned to the high-output MFR group and received MFR. If the stoma output was < 40 mL/kg/day, infants were randomized to the normal-output MFR group or the control group. Growth, serum citrulline levels, and bowel diameter in loopograms were compared. The safety of MFR was evaluated.Results: Twenty infants were included. The growth rate increased considerably, and the colon diameter was significantly larger after MFR. However, the citrulline levels did not significantly differ between the normal-output MFR and the control group. One case of bowel perforation occurred during the manual reduction for stoma prolapse. Although the association with MFR was unclear, two cases of culture-proven sepsis during MFR were noted.Conclusions: MFR benefits the growth and intestinal adaptation of preterm infants with enterostomy and can be safely implemented with a standardized protocol. However, infectious complications need to be investigated further.Trial registration: clinicaltrials.gov NCT02812095, retrospectively registered on June 6, 2016.