bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of 2,3-Dihydrosiloles via Palladium-Catalyzed Heck-type Arylation of Silacyclopentenes with Aryl Iodides
Authors: Huang Wei-Sheng , Ling Fang-Ying , Xu Li-Wen , Fang Xiao-Jun , Cui Yu-Ming , Ye Fei , Xu Zheng , Cao Jian , Yang Hua 
Published: December 2022

AbstractThe transition-metal-catalyzed synthesis of chiral silacycles is a challenging processes in organosilicon chemistry. Herein, we report a facile and regioselective synthesis of a novel class of 2,3-dihydrosilole derivatives with good yields via the palladium-catalyzed Heck-type reaction of silacyclopentenes (SCPs) with aryl iodides. Preliminary investigations on the enantioselective version of this palladium-catalyzed Heck-type process reveal that the presence of N-Boc-l-proline allows the diastereo- and enantioselective formation of chiral 2,3-dihydrosilole derivatives bearing both carbon and silicon-stereogenic centers.
Ectopic Olfactory Neuroblastoma: Systematic Review of a Rare Clinical Entity among Sinonasal Tumors
Authors: Lui Christopher G. , Badash Ido , Tang Liyang , Mark Michelle E. , Batra Pete S. , Wrobel Bozena B. 
Published: December 2022

Abstract
Objectives Ectopic olfactory neuroblastoma is an uncommon manifestation of an already rare neoplasm. We aimed to systematically review the literature for cases of ectopic olfactory neuroblastoma to better characterize this rare disease entity and to present two new case reports.
Methods A search of the PubMed and Embase databases was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify English-language articles reporting cases of ectopic olfactory neuroblastoma, published from 1955 through November 2021.
Results Sixty-six cases of ectopic olfactory neuroblastoma were identified in 62 articles including the current review. Ectopic olfactory neuroblastoma arose in a wide age range (2–89 years) without significant sex predilection. It occurred most commonly in the ethmoid (25%), maxillary (25%), and sphenoid (16%) sinuses. Seventy-three percent of cases presented with low Hyams grade (I and II). The most common symptoms were nasal obstruction (32%) and epistaxis (32%). Paraneoplastic syndromes were observed in 27% of patients. The most common treatment was surgical resection followed by adjuvant radiotherapy. Overall, 76% of all patients were disease-free at the time of last follow-up. Locoregional recurrences and distant metastases were found in 19 and 5% of cases, respectively.
Conclusion This systematic review describes previously reported cases of ectopic olfactory neuroblastoma, a disease entity with poorly understood characteristics. Physicians should consider olfactory neuroblastoma in the differential diagnosis for sinonasal masses, as their ectopic presentation may present considerable diagnostic and therapeutic difficulties. Patients with olfactory neuroblastoma may benefit from long-term follow-up and routine endoscopic examinations for surveillance of ectopic recurrences.
Effect of Esophagogastroduodenoscopy Volume and Gastric/Esophageal Pathology on the Rate of Lymphocytic Duodenosis Reporting in Children and Adolescents
Authors: Devara Janaki , Manini Mhd Louai , Murray Joseph A. , Absah Imad 
Published: December 2022

Abstract
Background It is not clear if the increase in the number of esophagogastroduodenoscopies (EGDs) performed has any significant effect on the rate of lymphocytic duodenosis (LD) reporting in children and adolescents and whether it correlates with abnormal gastric and/or esophageal pathology.”
Methods We performed a single-center retrospective study using the Mayo Clinic electronic health record and pathology database. We reviewed all EGD procedures performed in children and adolescents (<18 years) between January 1, 2000, and December 31, 2018, and identified two groups, the LD group and matched age and sex control group (normal duodenal biopsies). We evaluated the correlation of LD rate with the yearly number of EGDs performed and the presence of abnormal gastric and/or esophageal pathology.
Results Of 11,870 EGDs performed, we identified 338 (3%) individuals with LD and 390 (3%) randomly selected controls, with a mean (SD) age of 9.6 (5.3) and 11.7 (5.0) years, respectively. Based on logistic regression analysis, abnormal gastric histology was associated with the presence of LD when compared with controls (odds ratio, 2.85; 95% CI, 2.05–3.97; P < 0.001). The rate of LD-positive biopsies per year was highly correlated with the number of EGDs performed (ρ = 0.931; 95% CI, 0.826–0.974; P < 0.001).
Conclusion The rate of LD reporting is correlated with the number of EGDs performed and is more likely seen in children and adolescents with abnormal gastric histology.
Expression of PD-L1 in Lung Carcinoma and Its Correlation with Histopathological Grade, Stage, and Survival of Patients
Authors: Dhawan Vishesh , Chandra Smita , Kala Mansi , Khanduri Sushant 
Published: December 2022

Abstract
Objective PD-L1, a 40 kDa type 1 transmembrane protein, suppresses the adaptive arm of the immune system. The interaction of PD-1 with the ligand PD-L1 inhibits cytokine production and plays a role in the progression of lung cancer. The present study was performed to observe the expression of PD-L1 in lung carcinoma patients and its correlation with histopathological grade, stage, and survival of patients.
Materials and Methods This prospective study included all new cases of lung carcinoma diagnosed on histopathological or cytopathological examination over a period of 1 year. PD-L1 immunoexpression was statistically analyzed and graded according to the Tumor Proportion Score in all cases and correlated with histopathological grade, stage, and survival of patients.
Results This study included 56 cases of lung carcinoma with 64.2% cases showing PD-L1 positivity, out of which 44.6% were non-small cell and 19.6% were small cell lung carcinoma. In all, 32.1% cases with lymphovascular invasion, 53.5% with necrosis, and 37.5% cases with greater than 5/10 HPF mitotic figures showed positive PD-L1 expression. Paired cell blocks and histopathology showed 70% concordance for PD-L1 expression. 16.1% cT3N1M0 cases and 25% stage IIIA cases showed PD-L1 positivity. In all, 60.7% patients with positive PD-L1 expression did not survive for 12 months following diagnosis.
Conclusion PD-L1 immunoexpression was increased in lung carcinoma cases and was associated with poor histomorphological features including lymphovascular invasion, necrosis, and increased mitotic activity. PD-L1 correlated with cases having decreased 12-month survival and stage IIIA carcinoma. Thus, it may be useful in the stratification of patients who benefit from the PD-L1 targeted therapy.
Joubert Syndrome with Oral-Facial-Digital Defect (JS-OFD): A Brief Overview on Clinics and Genetics
Authors: Cuppari Caterina , Salpietro Annamaria , Chimenz Roberto , Colavita Laura , Ceravolo Maria Domenica , Gitto Eloisa , Sallemi Alessia , Fusco Monica , Ceravolo Ida , Farello Giovanni , Iapadre Giulia , Rocca Clarissa , Salazar Ainara , Mancuso Alessio 
Published: December 2022

AbstractJoubert's syndrome with digital facial oral defects represents a rare subgroup of Joubert's syndrome with related disorders. There are 11 forms of oral-facial-digital syndromes and are characterized by having neurological signs of JS associated with orofacial anomalies and often polydactyly. The most severe variant is the OFD type VI (Varadi-Papp syndrome) in which there are tongue hamartomas, multiple frenula, midline notch of the upper lip, mesoaxial polydactyly, and hypothalamic hamartomas. Treatments are symptomatic and supportive with reconstructive surgery for correctable malformation and physical therapy, occupational therapy, speech therapy, and infant stimulation for mental delay.
The Function and Role of the Cilium in the Development of Ciliopathies
Authors: Mancuso Alessio , Ceravolo Ida , Cuppari Caterina , Sallemi Alessia , Fusco Monica , Ceravolo Antonio , Farello Giovanni , Iapadre Giulia , Zagaroli Luca , Nanni Giuliana , Conti Giovanni 
Published: December 2022

Abstract“Ciliopathies” are a group of genetic disorders described by the malformation or dysfunction of cilia. The disorders of ciliary proteins lead to a range of phenotype from organ-specific (e.g., cystic disease of the kidney, liver, and pancreas, neural tube defects, postaxial polydactyly, situs inversus, and retinal degeneration) to sketchily pleiotropic (e.g., Bardet-Biedl syndrome and Joubert syndrome). The mechanism below the disfunction of cilia to reach new therapeutic strategies.
Bardet–Biedl Syndrome: A Brief Overview on Clinics and Genetics
Authors: Amore Greta , Spoto Giulia , Scuderi Anna , Prato Adriana , Dicanio Daniela , Nicotera Antonio , Farello Giovanni , Chimenz Roberto , Ceravolo Ida , Salpietro Vincenzo , Gitto Eloisa , Ceravolo Giorgia , Iapadre Giulia , Rosa Gabriella Di , Pironti Erica 
Published: December 2022

AbstractBardet–Biedl syndrome is a genetically pleiotropic disorder characterized by high clinical heterogeneity with severe multiorgan impairment. Clinically, it encompasses primary and secondary manifestations, mainly including retinal dystrophy, mental retardation, obesity, polydactyly, hypogonadism in male, and renal abnormalities. At least 21 different genes have been identified, all involved into primary cilium structure or function. To date, genotype–phenotype correlation is still poor.
The effective spin-splitting manipulation of monolayer WSe2 and Janus WSSe on SrIrO3(111) surface: A DFT study
Authors: Song Yiyao , Shi Bingjun , Lv Peng , Ma Dongwei , Zhang Weifeng , Jia Yu 
Published: December 2022

Spin regulation and manipulation in two-dimensional transition-metal dichalcogenides (TMDCs) is of great significance for two-dimensional spintronics. The electronic structure and spin feature of WSe2/SrIrO3(111) and WSSe/SrIrO3(111) interfaces were investigated by first-principles calculations with spin–orbital coupling, for which various and effective stacking configurations were considered. The spin-splitting of WSe2 at K point in the Brillouin zone can be significantly enhanced by the strong spin–orbital coupling of SrIrO3, while for WSSe, the enhanced spin-splitting is found at Q point. In particular, a small compressive strain of 1% can further strengthen the spin-splitting to 630 meV at K point, along with the p-type doping in WSe2. These findings provide a way to engineer the electronic structure and spin-splitting of TMDCs via strong interfacial spin–orbital coupling and appropriate strain field, which will extend their potential applications in spintronic devices.
Refutatoryna-sentences in Mandarin Chinese
Authors: Liu Chi-Ming Louis 
Published: December 2022

AbstractRefutatoryna-sentences possess several syntactic properties that are absent in their interrogative counterparts. First, they carry the assertive rather than interrogative force; second, they are mainly used to refute a claim made by another interlocutor. Given the fact that such a distinction is correlated with the position thatna‘where’ occupies in sentence, I propose that whennaserves as an interrogativewh-phrase, it is nominal and consists ofnaand an indefinite morpheme concerning location; in contrast, whennais a refutatory marker, it is an adjunct, containing an additional negative operator that binds a location-associated variable encoded in the indefinite morpheme. The refutatorynafurther has to move to the Spec of ForceP at LF to acquire the illocutionary force. This analysis not only accounts for the syntactic and pragmatic properties of the refutatoryna, but also supports the claim that Mandarinwh-arguments andwh-adjuncts are formed differently.
Desana numerical symbols
Authors: Overmann Karenleigh A. , Chacon Thiago , Payne Annick 
Published: December 2022

Abstract
In 2006, a narrative of the Desana people included a system of graphic symbols reported as a historical Indigenous
invention used during intertribal warfare to count the number of enemies and pass warning information. This paper outlines and
evaluates the Desana graphic system. The Desana people are described, and their timeline of mythical events is compared to
historical accounts of the region. Contemporary Desana spoken numbers are then characterized as a quinary system with a restricted
extent that differs significantly from the graphic writing system as presented in the cultural narrative. Implications for the
development of writing systems generally and numerical notations specifically are explored. We conclude that the numerical symbols
represent cultural diffusion of both European decimal numerals and the idea of writing. However, these were influenced by,
synthesized with, and ultimately transformed through their contact with Indigenous cultural practices and concepts, making them an
authentic Desana invention.
Using simulated Tianqin gravitational wave data and electromagnetic wave data to study the coincidence problem and Hubble tension problem*
Authors: Zhang Jia-Wei , Diao Jing-Wang , Pan Yu , Chen Ming-Yue , Li Jin 
Published: December 2022

Abstract
In this study, we used electromagnetic wave data (H0LiCOW,

, SNe) and gravitational wave data (Tianqin) to constrain the interacting dark energy (IDE) model and investigate the Hubble tension and coincidence problems. By combining these four types of data (Tianqin+H0LiCOW+SNe+

), we obtained the following parameter values with a confidence interval of

:

,

,

, and

. According to our results, the best value of

shows that the Hubble tension problem can be alleviated to some extent. In addition, the center value of

indicates that the coincidence problem is slightly alleviated. However,

is still within the

error range, which indicates that the ΛCDM model is still the model in best agreement with the observational data at present. Finally, we compared the constraint results of the electromagnetic and gravitational waves on the model parameters and found that the constraint effect of electromagnetic wave data on model parameters is better than that of simulated Tianqin gravitational wave data.
High dimensional AdS-like black hole and phase transition in Einstein-bumblebee gravity*
Authors: Ding Chikun , Shi Yu , Chen Jun , Zhou Yuebing , Liu Changqing 
Published: December 2022

Abstract
In this study, we obtained an exact high dimensional anti-de Sitter (AdS) black hole solution in Einstein-bumblebee gravity theory. This AdS-like black hole can only exist with a linear functional potential of the bumblebee field. We found that the Smarr formula and the first law of black hole thermodynamics can still be constructed in this Lorentz symmetry breaking black hole spacetime, but the conceptions of the black hole horizon area/entropy and the volume inside the horizon should be renewed due to its anisotropy. We also found that two types of phase transition exist: small-large black hole phase transition and Hawking-Page phase transition, like those of the Schwarzschild AdS black hole. After Lorentz symmetry breaking, the black hole mass at the divergent point of heat capacity becomes small, and the Gibbs free energy of the meta-stable large black hole is also smaller, showing that the large stable black hole can be more easily formed.
What can we learn from the total width of the Higgs boson?*
Authors: Cao Qing-Hong , Li Hao-Lin , Xu Ling-Xiao , Yu Jiang-Hao 
Published: December 2022

Abstract
As one of the key properties of the Higgs boson, the Higgs total width is sensitive to the global profile of the Higgs boson couplings, and thus new physics would modify the Higgs width. We investigate the total width in various new physics models, including various scalar extensions, composite Higgs models, and the fraternal twin Higgs model. Typically, the Higgs width is smaller than the standard model value due to mixture with other scalars if the Higgs is elementary, or curved Higgs field space for the composite Higgs. On the other hand, except for the possible invisible decay mode, the enhanced Yukawa coupling in the two Higgs doublet model or the exotic fermion embeddings in the composite Higgs could enhance the Higgs width greatly. The precision measurement of the Higgs total width at the high-luminosity LHC can be used to discriminate certain new physics models.
The Relationship Between Potential Occupational Sensitizing Exposures and Asthma: An Overview of Systematic Reviews
Authors: Dalbøge Annett , Albert Kolstad Henrik , Ulrik Charlotte Suppli , Sherson David Lee , Meyer Harald William , Ebbehøj Niels , Sigsgaard Torben , Zock Jan-Paul , Baur Xaver , Schlünssen Vivi 
Published: December 2022

Abstract

Objectives
The aim was to identify, appraise, and synthesize the scientific evidence of the relationship between potential occupational sensitizing exposures and the development of asthma based on systematic reviews.

Methods
The study was conducted as an overview of systematic reviews. A systematic literature search was conducted for systematic reviews published up to 9 February 2020. Eligibility study criteria included persons in or above the working age, potential occupational sensitizing exposures, and outcomes defined as asthma. Potential occupational sensitizing exposures were divided into 23 main groups comprising both subgroups and specific exposures. Two reviewers independently selected studies, extracted study data, assessed study quality, and evaluated confidence in study results and level of evidence of the relationship between potential occupational sensitizing exposures and asthma.

Results
Twenty-seven systematic reviews were included covering 1242 studies and 486 potential occupational sensitizing exposures. Overall confidence in study results was rated high in three systematic reviews, moderate in seven reviews, and low in 17 reviews. Strong evidence for the main group of wood dusts and moderate evidence for main groups of mites and fish was found. For subgroups/specific exposures, strong evidence was found for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals, whereas moderate evidence was found for 52 subgroups/specific exposures.

Conclusions
This overview identified hundreds of potential occupational sensitizing exposures suspected to cause asthma and evaluated the level of evidence for each exposure. Strong evidence was found for wood dust in general and for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals.
Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease
Authors: Trinh Joanne , Hicks Andrew A , König Inke R , Delcambre Sylvie , Lüth Theresa , Schaake Susen , Wasner Kobi , Ghelfi Jenny , Borsche Max , Vilariño-Güell Carles , Hentati Faycel , Germer Elisabeth L , Bauer Peter , Takanashi Masashi , Kostić Vladimir , Lang Anthony E , Brüggemann Norbert , Pramstaller Peter P , Pichler Irene , Rajput Alex , Hattori Nobutaka , Farrer Matthew J , Lohmann Katja , Weissensteiner Hansi , May Patrick , Klein Christine , Grünewald Anne 
Published: December 2022

Abstract
Biallelic mutations in PINK1/PRKN cause recessive Parkinson’s disease. Given the established role of PINK1/Parkin in regulating mitochondrial dynamics, we explored mitochondrial DNA integrity and inflammation as disease modifiers in carriers of mutations in these genes. Mitochondrial DNA integrity was investigated in a large collection of biallelic (n = 84) and monoallelic (n = 170) carriers of PINK1/PRKN mutations, idiopathic Parkinson’s disease patients (n = 67) and controls (n = 90). In addition, we studied global gene expression and serum cytokine levels in a subset. Affected and unaffected PINK1/PRKN monoallelic mutation carriers can be distinguished by heteroplasmic mitochondrial DNA variant load (area under the curve = 0.83, CI 0.74–0.93). Biallelic PINK1/PRKN mutation carriers harbour more heteroplasmic mitochondrial DNA variants in blood (P = 0.0006, Z = 3.63) compared to monoallelic mutation carriers. This enrichment was confirmed in induced pluripotent stem cell-derived (controls, n = 3; biallelic PRKN mutation carriers, n = 4) and post-mortem (control, n = 1; biallelic PRKN mutation carrier, n = 1) midbrain neurons. Last, the heteroplasmic mitochondrial DNA variant load correlated with IL6 levels in PINK1/PRKN mutation carriers (r = 0.57, P = 0.0074). PINK1/PRKN mutations predispose individuals to mitochondrial DNA variant accumulation in a dose- and disease-dependent manner.
Achieving and Sustaining Behavior Change for Older Adults: A Research Centers Collaborative Network Workshop Report
Authors: Hughes Jaime M , Brown Rebecca T , Fanning Jason , Raj Minakshi , Bisson Alycia N S , Ghneim Mira , Kritchevsky Stephen B 
Published: December 2022

Abstract
Modifying unhealthy behaviors and/or environments may improve or maintain an older adult’s health. However, achieving and sustaining behavior change is challenging and depends upon clinical, social, psychological, and political domains. In an effort to highlight the multidisciplinary nature of behavior change, the National Institute on Ageing (NIA) Research Centers Collaborative Network (RCCN) held a two-day workshop, achieving and sustaining behavior change for older adults. The workshop was informed by the socioecological model and designed to initiate dialogue around the individual, community, and systems-level determinants of behavior change. This article summarizes key topics presented during the workshop, discusses opportunities for future research, education, and training, and recommends how each of the six NIA research centers may pursue work in behavior change for older adults.
Novel thermostable GH5_34 arabinoxylanase with an atypical CBM6 displays activity on oat fiber xylan for prebiotic production
Authors: Norlander Siri , Jasilionis Andrius , Ara Zubaida Gulshan Kazi , Grey Carl , Adlercreutz Patrick , Karlsson Eva Nordberg 
Published: December 2022

Abstract
Carbohydrate active enzymes are valuable tools in cereal processing to valorize underutilized side streams. By solubilizing hemicellulose and modifying the fiber structure, novel food products with increased nutritional value can be created. In this study, a novel GH5_34 subfamily arabinoxylanase from Herbinix hemicellulosilytica, HhXyn5A, was identified, produced and extensively characterized, for the intended exploitation in cereal processing to solubilize potential prebiotic fibers: arabinoxylo-oligosaccharides. The purified two-domain HhXyn5A (catalytic domain and CBM6) demonstrated high storage stability, showed a melting temperature Tm of 61°C and optimum reaction conditions were determined to 55°C and pH 6.5 on wheat arabinoxylan. HhXyn5A demonstrated activity on various commercial cereal arabinoxylans and produced prebiotic AXOS, whereas the sole catalytic domain of HhXyn5A did not demonstrate detectable activity. HhXyn5A demonstrated no side activity on oat β-glucan. In contrast to the commercially available homolog CtXyn5A, HhXyn5A gave a more specific HPAEC–PAD oligosaccharide product profile when using wheat arabinoxylan and alkali extracted oat bran fibers as the substrate. Results from multiple sequence alignment of GH5_34 enzymes, homology modeling of HhXyn5A and docking simulations with ligands XXXA3, XXXA3XX and X5 concluded that the active site of HhXyl5A catalytic domain is highly conserved and can accommodate both shorter and longer ligands. However, significant structural dissimilarities between HhXyn5A and CtXyn5A in the binding cleft of CBM6, due to the lack of important ligand-interacting residues, is suggested to cause the observed differences in substrate specificity and product formation.