bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational And Biological Studies Of Platinum(II) Complex Of Tryptathrin Schiff Base
Authors: Dhaduk Milan P. , Dabhi Ravi A. , Bhatt Bhupesh S. , Bhatt Vaibhav D. , Patel Mohan N. 
Published: May 2022

Abstract
A series of tryptanthrin alkaloid based ligands (L1-L7) and corresponding platinum(II) complexes were synthesized and characterized by various spectroscopic techniques, LC-MS, magnetic measurement, and electronic spectra. DFT studies were performed for structure optimization. Viscosity measurement, UV-Vis spectroscopy, and molecular docking studies were used to determine the binding mode between CT-DNA and complexes; the intercalation mode of bindings was concluded from the study. The Kb values for compounds-DNA binding were found in the range of 0.42 × 105 – 3.90 × 105 M− 1. The binding study of complexes with BSA was evaluated by fluorescence quenching study, and the value of Ksv, binding constant (Ka), and binding site(n) were in the range of 1.14–2.70 × 103 M− 1, 0.13–0.55 × 105 M− 1, and 0.94–1.16, respectively. Bacteriostatic activity of the synthesized compound was performed against gram + ve and gram -ve bacteria. MIC values of complexes and ligands were found in the range of 35–75 µM and 150–245 µM, respectively. BSLB was performed to check the cytotoxicity of the synthesized compounds. The LC50 values of the ligands and complexes were found in the range of 9.24–11.18 µg/mL and 5.9–7.94 µg/mL, respectively. Anticancer activity against the MG-63 cell line was performed to check potency against the cancer cell line. The IC50 values of the synthesized compounds were found in the range of 10.9 µg/mL 28.7µg/mL. IC50 value of the complex III is 10.9 µg/mL, which is comparable with the standard drug cisplatin.
Assessment of farmers’ socioeconomic and conservation practice towards watershed management in the South West of Ethiopia
Authors: Woldeab Bizuneh , Ambelu Argaw , Beyene Abebe , Efrem Zewdu , Deribe Siyoum , Megersa Moa , Alemu Tibebu , Mereta Seid Tiku 
Published: May 2022

Abstract
Background
Watershed resource conservation is important for the wellbeing of the environment and communities. Understanding farmers’ socioeconomics and watershed conservation practices help in determining necessary interventions to address environmental threats. The study area is important at regional and national level due to the hydroelectric dam of the mega power project. This study deals with the farmers’ socio economic and conservation practices of Gilgel Gibe watershed. The study targeted 305 households in 4 districts of Jimma Zone surrounding the Gilgel Gibe Reservoir I. Semi-structured questionnaire was administered via interviews and focus group discussions led by trained survey interviewers.
Result
The findings of the study indicated that majority of farmers in the watershed have adequate knowledge, positive attitude and bad practice towards watershed conservation. To achieve better means of subsistence and improve their living condition farmers are forced to put stress on natural resource, degrading watershed and increase pollution loads that affect water quality of tributaries and reservoir.
Conclusion
Based on the present scenario, we forwarded stakeholders to establish team from the elders, officials at woreda and zonal level to initiate commitment, coordinate conservation activity and promote households’ income generating activities at homestead level like conservation agriculture.
Development and validation of risk score to predict in-hospital mortality among severely malnourished children under the inpatient treatment center: A follow up study
Authors: Mekonnen Eskedar Getie , Wagnew Fasil , Dadi Abel Fekadu , Hassen Hamid Yimam , Kassie Belayneh Ayanaw , Tilahun Ambaye Dejene , Gonete Almaz Tefera , Tarekegn Gebrekidan Ewnetu , Anlay Degefaye Zelalem , Mulatie Rahel , Takele Wubet Worku 
Published: May 2022

Abstract
Introduction: The prognosis of severely malnourished children is determined by various factors. The care provided to the child throughout the management is one of the most influencing factors for the child’s status after treatment. There is no evidence-based model that shows the risk of mortality among severely malnourished children. Thus, this study aimed to develop and validate a model to predict mortality among children with severe acute malnutrition.Method: We developed a prediction model using a retrospective cohort of 677 children with severe acute malnutrition admitted to the Amhara region referral hospitals. A stepwise multivariable analysis was done to develop the model. The accuracy of the model was evaluated using the area under the receiver operating characteristic curve (AUC) and calibration plot. All accuracy measures were internally validated using the bootstrapping technique. To improve the clinical applicability, a simplified risk score was developed to classify children with severe acute malnutrition at high or low risk of mortality. The clinical impact of the model was evaluated using a decision curve analysis across various threshold probabilities. Result: Child’s Age, the form of malnutrition, HIV/AIDS, heart failure, provision of antibiotics, and folic acid and vitamin A supplementation remained in the prediction model. The AUC of the model was 0.81 (95%CI: 0.76-0.85). The decision curve analysis indicated that the model provides higher net benefit across ranges of threshold probabilities. Conclusion: The model can guide clinicians in identifying severely malnourished children with a high risk of mortality. As the model showed easily obtainable predictors of mortality, it provides a considerable opportunity for care providers to avert hundreds of mortalities among those children. The model needs to be externally validated in another context before utilizing it for clinical decision-making.
A comparative study of initial 131I therapy and reoperation for detection and treatment of residual lymph node metastasis in patients with papillary thyroid cancer
Authors: Dai Hongyuan , Qi Zhibing , Huang Shuhui , Qi Mengfang , Huang Rui 
Published: May 2022

Abstract
Purpose This study assesses the diagnostic performance of 131I SPECT/CT and treatment efficacy of initial postoperative radioiodine (RAI) compared with reoperation on residual lymph node metastasis (LNM). Methods Patients with iodine-avid LNM detected on postoperative 131I SPECT/CT and who underwent re-operative dissection within 12 months were included. LNMs (numbers and locations) detected via both methods were compared. The ongoing risk stratification was used to evaluate the therapeutic response to RAI and reoperation. Results Fifty-three patients with 95 iodine-avid LNMs detected by 131I SPECT/CT were enrolled in this study. A total of 51 (96.2%) patients had 212 LNMs confirmed by reoperation (p=0.004). The sensitivity and specificity of 131I SPECT/CT in detecting LNM were 44.8% (95/212) and 91.6% (87/95), respectively. The location frequency of residual LNMs found by 131I SPECT/CT was similar to that of reoperation (p=0.057). Excluding 2 false-positive patients, the remaining 51 patients were in structural incomplete response (SIR) after a single RAI treatment. Sixteen patients were evaluated on a second RAI treatment after reoperation. The SIR, biochemical incomplete response (BIR), indeterminate response (IR) and excellent response (ER) were 4 (23.5%), 4 (23.5%),5 (29.4%) and 3 (17.6%), respectively (p=0.000). Conclusion 131I SPECT/CT has high specificity but relatively low sensitivity in finding all residual LNMs. Reoperation is more effective than RAI therapy, however, less than 20% of patients achieved ER. The success rate must be balanced with the risk of reoperation for residual LNMs.
Metabolomic Profiling of Equine Cord Blood Mesenchymal Stromal Cells in Both Early and Late Stages of Culture
Authors: Oji Saba , Pilgrim Cara Ruth , Koch Thomas Gadegaard , Madan Pavneesh 
Published: May 2022

Abstract
Introduction: Equine Mesenchymal Stromal Cells (MSC) hold great potential as a future form of cellular therapy. Fetal Bovine Serum (FBS) is used as a supplement MSC culture, but challenges with its use have initiated a desire to create a defined media to expand these cells. MSCs have shown great variability in species, tissue source and passage number. Due to this, to effectively create a replacement for FBS we must better understand how it meets the metabolic needs for each type of MSC. Objectives: The goal of this study is to determine key pathways and differences in pathways between the early and late passages of equine cord blood MSCs. Methods: This study utilized metabolomics to give a snapshot of the metabolism in the long-term culture of equine cord blood MSCs (eCB-MSC) by comparing the profile of plain culture media to spend media. Results: We found two significantly different metabolites between the early and late passage of eCB-MSC, alpha-ketoglutaric acid (p = 0.019) and creatine (p = 0.012). As well, the metabolic results allowed us to perform an enrichment analysis to assess which pathway(s) were most relevant. Conclusion: The two metabolites suggest a difference in metabolism between the early and late passage reflecting different cellular priorities. Insights into the unique metabolism of these cells and how the requirement of the cell differs between the early and late passage may allow the formulation a serum free media tailored to the metabolic needs of eCB-MSC.
The protective effect of selenium on the acute injury in S. aureus-infected mouse mammary gland
Authors: Junjun Liu , Guanjian Zhan , Yuping Zhao , Jianhua Qin , Yueshang Wang 
Published: May 2022

Abstract
In this study the protective effect of dietary Selenium during pregnancy on the acute mammary injury induced by S. aureus were observed. Eighty BALB/c pregnant mice were randomly divided into four groups: Control group (CG; Se-deficient basal diet during pregnancy without S. aureus infection; n = 20), Negative control (NG; 0.2 mg/kg Se-supplemented diet during pregnancy without S. aureus infection; n = 20), Positive group (PG; Se-deficient basal diet during pregnancy and infected with S. aureus four days after pregnancy; n = 20) and Treatment group (TG; 0.2 mg/kg Se-supplemented diet during pregnancy and infected with S. aureus. four days after pregnancy; n = 20). 24 h after infection, all mice were euthanized and the mammary tissues were sampling. Pathological section and scanning electron microscope were used to observe the pathologic injury in mammary gland, 54146 genes were detected by high throughput sequencing to identify the differentially expressed gene, ELISA was used to determine the expression level of IL-1β and TNF-α. Results shown that the mammary tissue structure were damaged by S. aureus, after selenium treatment the acute injury lightened, meanwhile 24434 were detected differentially expressed after S. aureus infection, which mainly regulate T cell activation, keratinization, cytokine production. Whereas only 20467 differentially expressed genes were detected in TG, in which genes code T cell activation and cytokine production were marked downregulated and gene code cell adhesion was upregulated. furthermore, selenium treatment significantly decreased the expression level of IL-1β and TNF-α induced by S. aureus. In conclusion, selenium played a protective effect on the acute injury in S. aureus-infected mouse mammary gland.
Factors Affecting the Readiness of Health Centers Staff to Use the Electronic Health Record System
Authors: Sadagheyani Hassan Ebrahimpour , Darrudi Reza , Mohammadpour Ali 
Published: May 2022

Abstract
Introduction: In an era when the collaboration of health organizations is an important key to provide effective healthcare services, the Implementation and widespread use of Electronic Health Record System (EHRS) are essential.Aim: The present study was designed to evaluate the factors related to the readiness of employees for using of the EHRS in health centers affiliated with Neyshabur University of Medical Sciences.Methods: The research population of the present cross-sectional study with 383 sample sizes included all healthcare providers in health centers affiliated with Neyshabur University of Medical Sciences who used the EHRS. A reliable and valid researcher-made questionnaire was used in this study. Data analysis was performed using SPSS V.22 software and Pearson correlation coefficient, t-test and ANOVA at the α= 0.05 significance level. Results: In the present study, 175 (45.7%) male and 208 (54.3%) females participated. There was a direct and significant relationship between the mean of International Computer Driving License (ICDL) scores and HER objectives and mission’s familiarity scores (14.9 ± 4.0 and 10.3 ± 2.6, respectively) (P = 0.000, r = 0.503). Among the human and technical as well as managerial factors, the human factor was one of the most effective factors regarding the use of the EHRS by staff. Conclusion: The effective implementation of the EHRS by staff is directly influenced by the following factors: employees' need for computer skills and related software, presence of medical IT specialists, the impact of EHRS on job position, and staff familiarity with EHRS objectives and missions.
Decision-making under uncertainty – a quantum circuit approach
Authors: Xin Lizhi , Xin Houwen 
Published: May 2022

Abstract
Decision’s biggest challenge is uncertainty. We propose a quantum expected value theory for decision-making under uncertainty. Decision-making under uncertainty is the unification of people’s subjective beliefs and the objective world. Quantum density operator as value operator which we call it quantum circuit is proposed to simulate people’s subjective beliefs. Quantum circuit guides people to choose corresponding actions based on their subjective beliefs through objective world. The quantum circuit is a decision tree constructed from quantum gates and logic operations. The genetic programming can be used to optimize and auto-generate quantum circuits. Our proposed synapse’s quantum circuit hypothesis states that the combination of neurotransmitter and receptor functioned as quantum circuit open or close ion channels probabilistically which determines the excitation or inhibition of synapse.
Long persistent Sinus arrest and Torsades de pointes association with Ibutilide after Atrial Fibrillation ablation：A Case Report
Authors: Li Qing , Guo Jinrui , Liu Ke , Ma Menghuai , Guo Tao , Liu Jun , Niu Guodong 
Published: May 2022

Ibutilide is commonly used for conversion of atrial fibrillation (AF)
during catheter ablation procedure. Sinus arrest or Torsades de Pointes
(TdP) is mainly complication of ibutilide, however, is recovery
spontaneously after a few hours.We present a patient suffering long
persistent sinus arrest and Torsades de pointes following administration
of ibutilide for cardioversion of persistent AF after radiofrequency
ablation.
Adaptation to Industry 4.0 in the Visegrád Group
Authors: Nurzyńska Dominika 
Published: May 2022

Motivation: The concept of Industry 4.0 is widely recognised, since technological development is an inseparable factor of the modern organisations functioning. Due to this, the interest in the subject of the 4th industrial revolution has grown in recent years. However, far too little attention has been paid to the measurement of readiness and implementation of key attributes in Czechia, Hungary, Poland and Slovakia.
Aim: The major objective of this study was to investigate the adaptation to Industry 4.0 in the Visegrád Group. Consequently, in the theoretical part both a historical context and a description of the main components of Industry 4.0 was introduced, which was the basis for the evaluation of the V4 transition toward Industry 4.0 in the empirical section.
Materials and methods: Both quantitative (basic statistical analysis) and qualitative (critical analysis of the subject literature) methods were used in this investigation. The research data was drawn mainly from institutional reports and Eurostat database.
Results: The investigation indicated that the transition towards Industry 4.0 in V4 countries is less advanced than in other European regions and need particular attention. Despite the relatively good results achieved in the field of robotisation, especially in the foreign-owned automotive industry, in general the Group lags behind the majority of Western and Baltic countries in terms of already adapted technologies, innovations and digital skills.
Euroscepticism in the Visegrád Group
Authors: Szewczyk Jarosław 
Published: May 2022

Motivation: Euroscepticism is an phenomenon which is becoming increasingly important. EU countries ought to enhance cooperation in the face of major challenges. Despite challenges facing the European Union too little attention has been devote exploration Euroscepticism with particular reference to the V4 countries.
Aim: The main objective of this study was to examine citizen?s Euroscepticism in the countries of the Visegrád Group. Accordingly, in the theoretical section were introduced definition of Euroscepticism, its classification and present differences in delineating of the phenomenon. Instigate an attempt to indicate the sources of Euroscepticism in the V4 countries and its characterize. The theoretical part was the basis for the empirical part in which was performed analysis results of Eurobarometer Public Opinion Researches.
Materials and methods: Quantitative (basic statistical analysis and ALSCAL algorithm) methods were used in this investigation. The research data was drawn from Eurobarometer opinion polls commissioned by the European Commission.
Results: The study indicated a varied level of Euroscepticism among the citizens of the Visegrad Group countries and the source of the whole phenomenon is strongly rooted in the sphere of migration. The Czechs are the most anti-European society from the V4 group. Reasearch on Euroscepticism must also be carried out at the level of the societies of individual states, and not only of political parties.
México en la región del Pacífico: procesos vigentes y desarrollos recientes
Authors: Ramírez Bonilla Juan José 
Published: May 2022

El texto pone el acento en las condiciones de operación del comercio internacional de México durante 2018-2020, y muestra, por un lado, los vínculos comerciales cada vez más intensos del país con sus contrapartes de Asia del Pacífico; y, por el otro, las nuevas tendencias hacia la regionalización de las estrategias productivas y comerciales de las empresas transnacionales y el papel central que México podríaa desempeñar en ese proceso. En ese contexto, el artículo destaca la lógica “importar para exportar”, determinante de la especialización de México como productor y exportador de manufacturas. Siguiendo esa lógica, durante el siglo XXI la economía mexicana ha transitado de la triangulación comercial “importación de insumos provenientes de China, para producir manufacturas en México y exportarlas a Estados Unidos” a la cuadrangulación “exportación de inversiones directas de países desarrollados a países en desarrollo de Asia del Pacífico, para producir insumos exportables a México, para procesarlos y exportarlos a Estados Unidos”. En gran medida, este proceso es la consecuencia necesaria del diferendo comercial sinoestadounidense y ha estado acompañado de la exportación de inversiones directas e insumos productivos desde Japón y Corea hacia México, para exportar al mercado estadounidense. Del lado mexicano, estos desarrollos han dado inicio a un proceso de sustitución de insumos antes importados por bienes de consumo intermedio producidos localmente por las empresas transnacionales y sus proveedores localizados en México; este proceso hacia la regionalización de la producción y el comercio globales es reforzado por las perturbaciones económicas provocadas por la pandemia de la covid-19, y para México representa la posibilidad de transitar hacia la lógica “producir para exportar”.
Enhancing Students Speaking Skills by Making Video Youtube TUTORIAL AS PROJECT BASED LEARNING
Authors: Tyas Novita Kusumaning , Fitriani Nining 
Published: May 2022

The aims of this study were to know how effective of making video tutorial as project-based learning to improve students speaking skills and to know the student’s attitude toward project-based learning. This study employed mix method design, both qualitative and quantitative research design. The researcher used purposive sampling. The selection was based on the characteristics of the population and the purpose of the study. The subjects were 30 students of informatics management program. The result of this study showed that the mean score of experimental group was higher than control group. The pronunciation aspect, the mean of experimental group got score 81.3 and in control group got score 75.07. In grammar aspect the mean score of experimental group was 80.9 and in control group was 73.63. The mean score of experimental group in vocabulary aspect was 81.4 and the control group was 74.5. The last aspect was fluency, the mean score in experimental group was 80.9 and in control group was 75.03. From the students attitudes also showed good effect toward implementation of project-based learning in improving students’ speaking skill.
How are Joko Widodo Figures Framed on Instagram during Covid-19 Pandemic? A Framing Analysis
Authors: Simarmata Rowinda Nicayana , Pasaribu Arsen Nahum 
Published: May 2022

This purpose of the study was to find the types of framing analysis and the purposes used by Joko Widodo during pandemic Covid-19. This research used a qualitative descriptive approach and the data were taken from the captions text of Joko Widodo's Instagram. Robert Entman's theory is used to find the types and the purposes of the uses of framing analysis. The data showed that there were 220 identified data from 55 captions found in the posts May and June 2020 about Covid-19. The findings of the research were classified into framing categories; Defining Problematic Effects, Identifying Causes, Conveying Moral Judgment, and Endorsing Remedy. The results found that Instagram framed Joko Widodo about the Covid-19 problem in Indonesia, where the Defining Problematic Effect that often appeared was that in the midst of a pandemic the government and society still commemorated national days well even though virtually it happened because of the Identifying Causes of the Covid-19 pandemic which continues to be the reason for the obstruction of community and government activities, therefore the government always urges the public to maintain the discipline that is always displayed in his posts in Conveying Moral Judgment and the Endorsing Remedy that Joko Widodo often calls for is to ask the local government and other ranks. to maximize safety during the Covid-19 pandemic.