bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Worldwide C3S CORDEX Grand Ensemble: A Major Contribution to Assess Regional Climate Change in the IPCC AR6 Atlas
Authors: Diez-Sierra Javier , Iturbide Maialen , Gutiérrez José M. , Fernández Jesús , Milovac Josipa , Cofiño Antonio S. , Cimadevilla Ezequiel , Nikulin Grigory , Levavasseur Guillaume , Kjellström Erik , Bülow Katharina , Horányi András , Brookshaw Anca , García-Díez Markel , Pérez Antonio , Baño-Medina Jorge , Ahrens Bodo , Alias Antoinette , Ashfaq Moetasim , Bukovsky Melissa , Buonomo Erasmo , Caluwaerts Steven , Chou Sin Chan , Christensen Ole B. , Ciarlò James M. , Coppola Erika , Corre Lola , Demory Marie-Estelle , Djurdjevic Vladimir , Evans Jason P. , Fealy Rowan , Feldmann Hendrik , Jacob Daniela , Jayanarayanan Sanjay , Katzfey Jack , Keuler Klaus , Kittel Christoph , Kurnaz Mehmet Levent , Laprise René , Lionello Piero , McGinnis Seth , Mercogliano Paola , Nabat Pierre , Önol Barış , Ozturk Tugba , Panitz Hans-Jürgen , Paquin Dominique , Pieczka Ildikó , Raffaele Francesca , Remedio Armelle Reca , Scinocca John , Sevault Florence , Somot Samuel , Steger Christian , Tangang Fredolin , Teichmann Claas , Termonia Piet , Thatcher Marcus , Torma Csaba , van Meijgaard Erik , Vautard Robert , Warrach-Sagi Kirsten , Winger Katja , Zittis George 
Published: September 2022

Abstract
The collaboration between the Coordinated Regional Climate Downscaling Experiment (CORDEX) and the Earth System Grid Federation (ESGF) provides open access to an unprecedented ensemble of regional climate model (RCM) simulations, across the 14 CORDEX continental-scale domains, with global coverage. These simulations have been used as a new line of evidence to assess regional climate projections in the latest contribution of the Working Group I (WGI) to the IPCC Sixth Assessment Report (AR6), particularly in the regional chapters and the Atlas. Here, we present the work done in the framework of the Copernicus Climate Change Service (C3S) to ­assemble a consistent worldwide CORDEX grand ensemble, aligned with the deadlines and ­activities of IPCC AR6. This work addressed the uneven and heterogeneous availability of CORDEX ESGF data by supporting publication in CORDEX domains with few archived simulations and performing quality control. It also addressed the lack of comprehensive documentation by compiling information from all contributing regional models, allowing for an informed use of data. In addition to presenting the worldwide CORDEX dataset, we assess here its consistency for precipitation and temperature by comparing climate change signals in regions with overlapping CORDEX domains, obtaining overall coincident regional climate change signals. The C3S CORDEX dataset has been used for the assessment of regional climate change in the IPCC AR6 (and for the interactive Atlas) and is available through the Copernicus Climate Data Store (CDS).
RTV-SiR based composites aged in a multi-stressed environment under AC and bipolar DC voltages
Authors: Mahmood Atif , Alam Shahid 
Published: September 2022

Silicone rubber-based polymers are gradually replacing traditional insulators in outdoor applications due to their numerous advantages, in particular high hydrophobicity that is important for suppressing leakage current and hence surface flashover. However, the main problem with polymeric composites is their aging when exposed to environmental stresses causing loss of their desired properties and expected lifetime. In this work, aging behavior of three types of room temperature vulcanized silicon rubber (RTV-SiR) loaded with nano-silica and micro-ATH is studied. Samples of the materials with different specifications were fabricated and exposed to various environmental stresses in two specially designed weather chambers under both AC and bipolar DC voltages for a time period of 9000 hours. Thereafter, diagnosis was performed for identifying the degree of deterioration using several techniques. These include hydrophobicity classification, measurements of leakage current and mechanical properties, Fourier transform infrared spectroscopy, and Thermogravimetric analysis. Results of the conducted experiments indicated stronger degradation of the desired properties under positive DC stress as compared to the AC and negative DC voltages. Moreover, silicone rubber doped with nano-sized particles of silica filler demonstrated better anti-aging performance as compared to its micro-ATH filled counterpart.
Self-management of falls in people with multiple sclerosis: A scoping review
Authors: Tuvemo Johnson Susanna , Flink Maria , Peterson Elizabeth , Gottberg Kristina , Elf Marie , Johansson Sverker , Kierkegaard Marie , Ytterberg Charlotte 
Published: September 2022

Objective Falls are common in people with multiple sclerosis. There is rising interest in how the multifactorial and chronic nature of fall risk among people with multiple sclerosis can be addressed through self-management. Thus, the aims were to investigate the extent and the scope of publications on self-management of falls in people with multiple sclerosis, and to identify how the concept of self-management was defined and used. Data sources A systematic literature search in Medline, Cochrane, Web of Science and PsycInfo was conducted to identify publications until July 2022. Review methods Published methodological guidance was followed. Articles targeting: (1) people with multiple sclerosis, (2) falls, and (3) self-management were selected. Of 1656 records, 203 publications were assessed for eligibility, of which 173 did not meet the inclusion criteria, and 16 publications did not contain empirical data. The type of publication, study focus, and study design was extracted. If applicable, key findings, self-management tasks and skills, and the definition of self-management were extracted. Results Fourteen original articles met all inclusion criteria. Ten articles represented six different fall prevention interventions. Three publications were randomized controlled trials. Self-management content was variable and not comprehensive in nature. None of the 14 publications included a self-management definition. Conclusion The limited number of original articles and the even fewer intervention studies show that the research on self-management of falls in people with multiple sclerosis is in its infancy. To progress in the research area of self-management of falls, a more robust, consensus-based description of self-management frameworks and activities is needed.
Target temperature management versus normothermia without temperature feedback systems for out-of-hospital cardiac arrest survivors
Authors: Lee Hui Jai , Shin Jonghwan , You Kyoung Min , Kwon Woon Yong , Kim Kyung Su , Jo You Hwan , Park Seung Min 
Published: September 2022

Objective The clinical benefit of automatic temperature control devices remains unclear. We investigated the outcomes of out-of-hospital cardiac arrest (OHCA) survivors who had undergone either target temperature management (TTM) with a temperature feedback system (TFS) or maintenance of normothermia without a TFS during post-resuscitation care. Methods This study was a retrospective analysis of a multicenter prospective cohort of OHCA survivors who had received postcardiac arrest care from August 2014 to December 2018. The overlap propensity score weighting method was applied for adjustment between groups. Results A total of 405 OHCA survivors were included. TTM with a TFS and normothermia without a TFS were applied to 318 and 87 patients, respectively. Fever events were more common in patients with normothermia without a TFS. After propensity score matching, no statistically significant differences were observed in the 1-month good neurologic outcome (odds ratio 0.99, 95% confidence interval [CI] 0.56–1.25) or survival rate (odds ratio 1.25, 95% CI 0.88–1.78). Conclusion No significant differences in the 1-month neurologic outcome were observed between patients receiving TTM with a TFS and those undergoing normothermia without a TFS.
Effect of direct stenting on microvascular dysfunction during percutaneous coronary intervention in acute myocardial infarction: a randomized pilot study
Authors: Kim Byung Gyu , Cho Sung Woo , Seo Jongkwon , Kim Gwang Sil , Jin Moo-Nyun , Lee Hye Young , Byun Young Sup , Kim Byung Ok 
Published: September 2022

Objective Whether direct stenting (DS) without predilatation during primary percutaneous coronary intervention (PPCI) reduces microvascular dysfunction in patients with ST-elevation myocardial infarction is unclear. We performed a randomized study to assess the effect of DS on microvascular reperfusion. Methods Seventy-two patients undergoing PPCI were randomly assigned to the DS or conventional stenting (CS) with predilatation groups. The primary endpoint was the post-PPCI index of microcirculatory resistance (IMR). We compared thrombolysis in myocardial infarction myocardial perfusion (TMP) grades, ST-segment resolution, and long-term clinical outcomes between the groups. Results Microvascular reperfusion parameters immediately after PPCI (e.g., the IMR, TMP grade, and ST-segment resolution) were not different between the groups. However, significantly fewer patients in the DS group had the IMR measured because of no-reflow or cardiogenic shock during PPCI than those in the CS group. No differences were found in left ventricular functional recovery or clinical outcomes between the groups. Conclusions This trial showed no effect of DS on the IMR. However, our finding should be interpreted with caution because the number of patients who could not have the IMR measured was higher in the CS group than in the DS group. A larger randomized trial is required (Research Registry number: 8079).
Curcumin treatment attenuates cisplatin-induced gastric mucosal inflammation and apoptosis through the NF- κ B and MAPKs signaling pathway
Authors: Gao Jinping , Liu Yunen , Chen Juan , Tong Changci , Wang Qian , Piao Ying 
Published: September 2022

To investigate the protective effects of curcumin (Cur) on gastric mucosal injury induced by cisplatin (DDP), and explore possible molecular mechanisms. A mouse of gastric mucosal injury was established by intraperitoneal injection of DDP (27 mg/kg). Thirty mice were randomly divided into control group, DDP group and DDP + Cur group. Serum and gastric mucosal samples were collected on the 7th day after Cur treatment. The index of gastric mucosa injury was calculated, and the expression levels of inflammation, apoptosis and signaling pathway proteins were evaluated using hematoxylin and eosin staining, ELISA and western blotting analysis. These data showed that Cur treatment significantly attenuated DDP-induced decrease in body weight, food intake, fat and muscle ratios, and improved the gross gastric injury, scores of ulcer index, and histopathology changes triggered by DDP ( p < .05). Meanwhile, Cur significantly decreased serum IL-23 and IL-17 proteins, reduced the expression levels of gastric mucosal IL-1β, TNF- α and MPO, and restored the level of IL-10 protein ( p < .05). Moreover, Cur treatment significantly inhibited the expression levels of Caspase-3, PARP and Bax, and increased the expression of Bcl-2 protein. Furthermore, Cur treatment significantly decreased the expression levels of IL-1R, MyD88 and TAK1, and also repressed the activation of NF-κB and nuclear translocation of NF-κB p65. And more importantly, Cur treatment significantly inhibited DDP-induced gastric mucosal JNK1/2, ASK1, P38 and JUN phosphorylation, and promoted the phosphorylation of ERK1/2 and C-Myc proteins. Our data suggest that Cur treatment alleviates DDP-induced gastric mucosal inflammation and apoptosis, which may be mediated through the NF- κ B and MAPKs signaling pathway.
Management of talar lesions with cement augmentation and autologous bone graft
Authors: Kim Do Hun , Kim Wanlim , Choi Youngrak 
Published: September 2022

Background Treatment of bone lesions involved with the articular cartilage at the talus is challenging. We report the management of talus lesions, particularly tumors and avascular necrosis (AVN), at the articular surface through treatment with cement augmentation and autologous bone graft. Methods Eight benign bone tumors and three cases of AVN were reviewed retrospectively at a mean follow-up of 56 months (range, 12–162). The mean age of all patients was 36.1 years old (range, 15–73) when assessed between February 2005 and November 2021. Curettage of tumorous and necrotic lesions resulted in significant bone defects filled with bone cement augmentation. Cartilage defects of the talar dome were supported with autologous cancellous bone graft. Tolerable weight-bearing ambulation was permitted immediately after surgery. Radiological and functional evaluations were recorded. Results We observed an increase in the average The American Orthopaedic Foot and Ankle Score (AOFAS) ( p = .003) and a decrease in the average Visual Analogue Scale pain score ( p = .003). There was no statistically significant decrease in ROM before or after surgery ( p = .114). Additionally, no talus collapse of the ankle joint occurred. Talar dome status did not aggravate before or after surgery, except for one patient. Despite no radiographic osteoarthritis exacerbation before or after surgery in six patients, five patients had osteoarthritic change. Conclusion Cement implantation and autologous bone graft performed simultaneously for benign bone tumors with joint cartilage damage and AVN are technically simple, have good outcomes, and may be a suitable alternative to standard treatments.
Recurrent disability progression endpoints in multiple sclerosis clinical trials
Authors: Bühler Alexandra , Wolbers Marcel , Model Fabian , Wang Qing , Belachew Shibeshih , Manfrini Marianna , Lorscheider Johannes , Kappos Ludwig , Beyersmann Jan 
Published: September 2022

Background: The current standard endpoint to assess disability accumulation in multiple sclerosis (MS) clinical trials is the time to the first confirmed disability progression, which excludes subsequent progression events. Including recurrent progression events may permit a more comprehensive assessment of treatment effects on disability progression. Objective: To propose a definition of recurrent disability progression events and to compare time-to-first and recurrent event analysis. Methods: Recurrent disability progression events were defined by expanding the recommended first event definition. Marginal recurrent event methods (negative binomial model, Lin–Wei–Yang–Ying model) were compared with Cox regression in data from three randomized controlled trials in relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS), and in simulated randomized controlled trial data. Results: The recurrent event analyses included a substantially larger number of progression events compared with the time-to-first-event analyses (+7.5% and +9.9% in the RMS trials and +22.7% in the PPMS trial). The increase in the number of events resulted in more precise treatment effect estimates and a corresponding gain in statistical power. Conclusion: Our results support the use of recurrent event data analysis, especially in progressive MS trials, to improve estimates of treatment effects, increase statistical power, and better capture the clinically meaningful long-term disability progression experience.
Role of Combined CT Pulmonary Angiography and Indirect CT Venography in Diagnosing Venous Thromboembolism in COVID-19 Patients – Experience From an Indian Quaternary Centre
Authors: Kalyanasundaram Srinivasan , Sudarsanam Hemanth , Dhas Daspin , Shankar Abhinaya , Varadan Baskaran , Ethiraj Dillibabu , Rajakumar Akila , A.C Sathya , Devarajan Vidya , Hakeem Abdul Rahman 
Published: September 2022

Objectives To study the role of combined CTPA and indirect CT venogram to diagnose venous thromboembolism (VTE) in patients with COVID-19 pneumonia and to compare the clinical characteristics, laboratory parameters, CT findings and clinical outcomes between the VTE positive and negative groups. Methods In this retrospective study, 131 patients with COVID-19 pneumonia who underwent CTPA and venogram between August 2020 and January 2021 were included. Relevant demographical, clinical and laboratory data and CT images were collected. Two thoracic radiologists independently reviewed the CTPA and venogram images. Results VTE was identified in 29 patients (22% of the study population). CT venogram identified DVT in 9 patients. No statistical difference was observed between the two groups with respect to age, gender, BMI and presence of comorbidities. There was a significant difference in the hospital stay duration, which is increased in the VTE positive group. The number of patients who were dependent on oxygen and mortality were also high in the positive group. There was statistically significant difference in the mean D-dimer value and the mean Neutrophil/lymphocyte ratio, which were higher in the VTE positive group. Conclusion Combined CTPA and venogram can be used as a one-stop investigation for diagnosing PE and DVT of lower limbs in patients with COVID-19 pneumonia. CTPA with venogram should be performed in patients with D-dimer value in the range of 1000 – 1200 μg/L and above to rule out VTE as the hospital stay duration and final outcomes vary between the positive and negative groups.
Efficacy of neoadjuvant docetaxel + cisplatin chemo-hormonal therapy versus docetaxel chemo-hormonal therapy in patients with locally advanced prostate cancer with germline DNA damage repair gene alterations
Authors: Chi Chenfei , Liu Jiazhou , Fan Liancheng , Zhu Yinjie , Wang Yanqing , Sha Jianjun , Huang Yiran , Dong Baijun , Pan Jiahua , Xue Wei 
Published: September 2022

Purpose: To assess the efficacy and safety of neoadjuvant docetaxel + cisplatin chemotherapy with androgen deprivation therapy for the treatment of locally advanced prostate cancer (PCa) in patients harboring germline DNA damage repair genes (gDDR) defects. Methods: We conducted a prospective observational study in patients with locally advanced PCa confirmed with gDDR defects through next-generation sequencing. All patients received either docetaxel + cisplatin (platinum-group) or docetaxel chemo-hormonal therapy (docetaxel group) followed by radical prostatectomy with extended lymphadenectomy. The primary end point was biochemical progression-free survival (bPFS) and secondary end points include postoperative pathological response and safety assessment during the study period. Results: A total of 36 patients were included in the study, among whom 14 and 22 patients received docetaxel + cisplatin and docetaxel treatment, respectively. Down-staging of Tumor (T), Nodes (N), and Metastasis (M) stages was observed in 11 (78.57%) and 9 (40.9%) patients ( p = 0.041), respectively, in the docetaxel + cisplatin group and docetaxel group. The median bPFS was 7.76 months (95% CI 0.770–14.748) and not reached in the docetaxel group and docetaxel + cisplatin group, respectively. bPFS was significantly longer in the docetaxel + cisplatin group ( p = 0.039) with a hazard ratio of 0.386 (95% CI 0.151–0.987, p < 0.05). Furthermore, one patient discontinued docetaxel + cisplatin after second cycle due to severe liver insufficiency which was confirmed as viral hepatitis A and no significant perioperative complications was observed in either group. Conclusion: This study suggests that cisplatin may increase docetaxel anticancer activity with tolerable safety profile in patients with locally advanced PCa carrying gDDR defects in the neoadjuvant setting, a hypothesis which will require prospective, randomized confirmation.
Differences in brain connectivity of meditators during assessing neurocognition via gamified experimental logic task: A machine learning approach
Authors: Savanth Ashwini S , PA Vijaya , Nair Ajay K , Kutty Bindu M 
Published: September 2022

Meditation practices increase attention, memory, and self-awareness. The neuroscientific study of meditation has helped gain useful insights into the functional changes in the brain. In this study, we have assessed the performance of meditators with different years of practice while performing an engaging task rather than studying the meditation practice itself. This task helps assess many neural processes simultaneously and represents task performance in presence of multiple audio-visual distractors as in a real-life scenario. The long-term practice of meditation could bring neuroplastic changes in the way cognitive processing is carried out. It could be conscious and effortful in short-term practitioners and relatively unconscious and effortless in long-term practitioners. Our goal is to understand if it is possible to differentiate between long-term and short-term meditators solely based on their cognitive processing. A group of proficient Rajayoga meditators from the Brahma Kumaris were recruited based on their meditation experience—Long-Term Practitioners ( n = 12, mean 13,596 h) and Short-Term Practitioners ( n = 10, mean 1095 h). A task-based functional Magnetic Resonance Imaging was acquired while the subjects performed the task. Functional Connectivity Analysis was performed to derive the correlation measures to be used as features for classification. Five supervised Machine Learning algorithms Logistic Regression, Support Vector Machine, Decision Tree, Random Forest, and Gradient Boosted Tree were used for classification. Among all the classifiers Gradient Boosted Tree performed the best with an accuracy of 77% when all the four Functional Connectivity Metrics were used. Connectivity in visual areas, cerebellum, left rostral prefrontal cortex, and middle frontal gyrus was found to be higher in long-term meditators. Such a classification demonstrates that long-term meditation practice brings about neuroplastic changes that influence cognitive processing.
The Impact of COVID-19 Pandemic on Spine Surgeons Worldwide: A One Year Prospective Comparative Study
Authors: Barajas Juan N. , Hornung Alexander L. , Kuzel Timothy , Mallow Gary M. , Park Grant J. , Rudisill Samuel S. , Louie Philip K. , Harada Garrett K. , McCarthy Michael H. , Germscheid Niccole , Cheung Jason PY. , Neva Marko H. , El-Sharkawi Mohammad , Valacco Marcelo , Sciubba Daniel M. , Chutkan Norman B. , An Howard S. , Samartzis Dino 
Published: September 2022

Study Design Survey Objective In March of 2020, an original study by Louie et al investigated the impact of COVID-19 on 902 spine surgeons internationally. Since then, due to varying government responses and public health initiatives to the pandemic, individual countries and regions of the world have been affected differently. Therefore, this follow-up study aimed to assess how the COVID-19 impact on spine surgeons has changed 1 year later. Methods A repeat, multi-dimensional, 90-item survey written in English was distributed to spine surgeons worldwide via email to the AO Spine membership who agreed to receive surveys. Questions were categorized into the following domains: demographics, COVID-19 observations, preparedness, personal impact, patient care, and future perceptions. Results Basic respondent demographics, such as gender, age, home demographics, medical comorbidities, practice type, and years since training completion, were similar to those of the original 2020 survey. Significant differences between groups included reasons for COVID testing, opinions of media coverage, hospital unemployment, likelihood to be performing elective surgery, percentage of cases cancelled, percentage of personal income, sick leave, personal time allocation, stress coping mechanisms, and the belief that future guidelines were needed (P<.05). Conclusion Compared to baseline results collected at the beginning of the COVID-19 pandemic in 2020, significant differences in various domains related to COVID-19 perceptions, hospital preparedness, practice impact, personal impact, and future perceptions have developed. Follow-up assessment of spine surgeons has further indicated that telemedicine and virtual education are mainstays. Such findings may help to inform and manage expectations and responses to any future outbreaks.