bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Osteoporosis Medications for Patients With Chronic Kidney Disease: An Updated Systematic Review and Network Meta-Analysis
Authors: Chen Chia-Hsien , Lo Wei-Cheng , Hu Ping‐Jen , Chan Hsiu-Chen , Shen Wan-Chen , Wu Mai-Szu , Wu Mei-Yi 
Published: February 2022

Background: Chronic kidney disease (CKD) is associated with bone and mineral metabolism. In this study we evaluated the comparative efficacies and safety of osteoporosis medications in patients with CKD or a history of kidney transplantation, and make recommendations for the best choice of osteoporosis treatment among patients with CKD or a history of kidney transplantation.Methods: We systemically searched for randomized controlled trials published in PubMed, Embase, and Cochrane databases up to June 2020. Network-meta analysis was used to compare the relative effectiveness of different treatments. A random-effects model was used when heterogeneity was expected. The safety of different treatments was also evaluated in terms of reported major adverse events.Results: A total of 17 studies with data from 10,214 patients who had stage 2–5 CKD, were receiving dialysis, or had a history of kidney transplantation were included in the network meta-analysis. Treatment with teriparatide, denosumab, alendronate, and raloxifene were all associated with a significantly reduced risk of fractures compared to treatment with placebos [teriparatide: odds ratio (OR) = 0.19, 95% confidence interval (CI): 0.10–0.35; denosumab: OR = 0.40, 95% CI: 0.27–0.58; alendronate: OR = 0.61, 95% CI: 0.40–0.92; raloxifene: OR = 0.52, 95% CI: 0.41–0.67]. The rank probability and the surface under the cumulative ranking (SUCRA) values suggested that teriparatide ranked the highest for improvement in vertebral bone mineral density (BMD) (SUCRA = 97.8%), whereas denosumab ranked the highest for improvement in femoral neck BMD (SUCRA = 88.3%).Conclusion: Teriparatide and denosumab seem to be the most effective treatments for preventing bone loss and reducing the risk of fracture in our network comparison. However, because of the limitations and potential biases in the reviewed studies, there is still some uncertainty about the best treatment options for osteoporosis in patients with CKD or a history of kidney transplantation.Systematic Review Registration: [PROSPERO], identifier [CRD42020209830].
Pilot Study on the Effects of the Teaching Interpersonal Skills Program for Teens Program (PEHIA)
Authors: Serrano-Pintado Isabel , Escolar-Llamazares María-Camino , Delgado-Sánchez-Mateos Juan 
Published: February 2022

Background/ObjectiveSocial skills are essential in adolescence, both for their relational dimension and for their influence on other areas of adolescent life, so it is essential to include Social skills in the formal education of students.MethodThis paper presents the results of an experimental mixed factorial design pilot study in which an Interpersonal Skills Training Program for Adolescents (PEHIA1) was applied. The convenience sample consisted of 51 adolescents. An evaluation was carried out before and after the intervention, using the CEDIA (Adolescent Interpersonal Difficulties Assessment Questionnaire) and SAS-A (Social Anxiety Scale for Adolescents) questionnaires.ResultsThe mixed factorial ANOVA show significant differences in the overall measures and in most of the subscales of both questionnaires, indicating that PEHIA is effectiveness, at least in the short term.ConclusionsThe results obtained in assertiveness, interpersonal relationships and public speaking suggest that the program is feasible and shows promising results in reducing anxiety. However, a larger scale study should be conducted.
Anxiety, Depression, and Stress Are Associated With Internet Gaming Disorder During COVID-19: Fear of Missing Out as a Mediator
Authors: Wang Yang , Liu Bingjie , Zhang Lei , Zhang Peng 
Published: February 2022

BackgroundMany teenagers suffered negative emotional states, especially anxiety and depression, during the COVID-19 outbreak, and most teenagers choose Internet games to cope with negative emotion. Previous evidence indicated that fear of missing out is related with anxiety and depression in teenagers with Internet gaming disorder, but it is unclear how fear of missing out influences depression, anxiety, or stress.MethodsBased on an I-PACE model, using Depression, Anxiety, Stress Scale (DASS-21), Fear of Missing Out Scale, and Internet Gaming Addiction Scale, and 324 middle school students as participants, this study explored the mediating effect of fear of missing out on depression, anxiety, or stress and Internet gaming disorder.ResultsThe results showed that depression and stress are significantly related to Internet gaming disorder through the partial mediating of fear of missing out. Anxiety is not significantly related to Internet gaming disorder through the full mediating of fear of missing out, and anxiety and stress have a greater predictive effect on Internet gaming disorder through fear of missing out. Results also demonstrated that students who play Honor of Kings or Player Unknown's Battlegrounds have more risk to develop Internet gaming disorder.ConclusionsThe results indicated that fear of missing out as a mediator regulates the relationship among depression, anxiety, and stress and Internet game disorder. Specifically, under the mediation of fear of missing out, teenagers with anxiety are more likely to develop Internet gaming disorder, while teenagers with depression or stress might be prone to other types of Internet use disorders.
Association Between Functional Limitations and Incident Cardiovascular Diseases and All-Cause Mortality Among the Middle-Aged and Older Adults in China: A Population-Based Prospective Cohort Study
Authors: Hu Zhao , Zheng Baohua , Kaminga Atipatsa Chiwanda , Zhou Feixiang , Xu Huilan 
Published: February 2022

BackgroundThe prevalence of functional limitations is relatively high among the middle-aged and older adults. However, the contribution of functional limitations to subsequent incident cardiovascular diseases (CVD) and death is unclear. This study aims to examine the association between functional limitations and incident CVD and all-cause mortality among the middle-aged and older adults.MethodsThis is a nationally representative prospective cohort study. Participants were middle-aged and older Chinese adults from The China Health and Retirement Longitudinal Study. Functional limitations were measured using activities of daily living (ADL) scale and instrumental activities of daily living (IADL) scale. Incident CVD and death were recorded at followed-up from June 1, 2011, up until August 31, 2018. Cox proportional hazards model was used to assess the association between functional limitations and incident CVD and all-cause mortality.ResultsA total of 11,013 participants were included in this study. During the 7 years of follow-up, 1,914 incident CVD and 1,182 incident deaths were identified. Participants with functional limitations were associated with a 23% increased risk of incident CVD (HR, 1.23, 95% CI:1.08,1.39) after adjusting for age, gender, residential area, marital status, education, smoking, alcohol drinking, sleep duration, nap duration, depression symptoms, social participation, history of hypertension, diabetes, dyslipidemia, use of hypertension medications, diabetes medications, and lipid-lowering therapy. Moreover, participants with functional limitations were associated with a 63% increased risk of all-cause mortality (HR,1.63, 95%CI: 1.41,1.89) after adjusting for potential confounders.ConclusionsFunctional limitations were significantly associated with subsequent incident CVD and death among the middle-aged and older Chinese adults.
Applied Mindfulness for Physician Wellbeing: A Prospective Qualitative Study Protocol
Authors: Weisbaum Elli , Chadi Nicholas 
Published: February 2022

BackgroundPhysician burnout has significant adverse impacts on the wellbeing of individual physicians, and by extension the healthcare delivery systems of which they are part. Mindfulness is consistently cited as a pragmatic approach to effectively address burnout and enhance physician wellbeing. However, very few empirical studies have been published on Mindfulness Based Interventions (MBIs) for physicians. Moreover, the majority of these studies have been quantitative, leaving a gap in understanding the practical application of mindfulness in the context of physicians' daily lives.ObjectivesThis paper outlines the rationale, development and design of a novel prospective qualitative study examining the acceptability, feasibility, and pragmatic application of a mindfulness intervention for physician wellness.MethodsThe study will be conducted in three groups of at least 8 practicing physicians from a broad range of medical specialties at a tertiary care hospital in a large urban center in Eastern Canada. The intervention will consist of an innovative program based on the teachings of internationally renowned scholar and Zen Master Thích Nhãt Hạnh. It will include 5 weekly 2-h mindfulness sessions delivered by two health providers trained in mindfulness and in the teachings of Thich Nhat Hanh. The primary outcome measure will be an in-depth Thematic Analysis of post-program semi-structured interviews. Field data will also be collected through participant observation. The study will be theoretically grounded within the interpretive paradigm utilizing “the Mechanisms of Mindfulness Theory”. An external advisory committee formed by four senior members of Thích Nhãt Hạnh's community will provide guidance across all phases of the study.DiscussionOur innovative approach provides a new framework to further understand the mechanisms by which mindfulness interventions can impact physician wellbeing, and by extension their patients, colleagues, and broader healthcare systems. Through a clear articulation of the rigorous application of accepted procedures and standards used in our protocol, this paper seeks to provide a roadmap for other researchers who wish to develop further studies in this area. Lessons learned in the preparation and conduction of this study can be applied to other healthcare contexts including non-physician health provider wellbeing, clinical care, and population-level mental health.
ANALYSIS OF TEACHERS’ CREATIVITY IN MEDIA-BASED LEARNING GRADE X AT SMK PENCAWAN MEDAN
Authors: Doloksaribu Likawati , Meliala Epria Primsa , Purba Pebri Wati Romatua , Panjaitan Lavia 
Published: February 2022

ABSTRACT
This study aims to describe the creativity of English teachers when SMK Pencawan Medan grade X use learning media. This research is descriptive. The data is obtained through interviews. The data analysis followed some steps, namely collecting data, reducing, display data, data verification and create reports. The results showed that teachers employed the various teaching-learning media in ELT classes. English teachers used various media to make it easier for students to learn and understand the teaching materials. The media include audio, visual, and audio visual. The most media used in the ELT classes were audio and visual. A small part of the media is produced through internet sources. However, the teacher’s implementation method is not optimal. This can be seen from the imperfect application of the PowerPoint medium when the teacher uses the power point medium. Not every day teachers use the learning medium to achieve their learning goals. Based on the conclusion above, the researchers give suggestion to the teachers should always looking for creative new things and create active, innovative, and fun learning, and also motivate students to seriously participate in learning even though they study through online.
Keywords : Creativity, Learning media
RELATEDNESS BETWEEN K13 ENGLISH CURRICULUM AND WRITING MATERIALS IN BAHASA INGGRIS TEXTBOOK
Authors: Yanti Wirda , Silaban Alisa Franstia Maria , Saragih Erikson 
Published: February 2022

Abstract
Textbook is an important media because contains learning materials that employed learners to get knowledge through learning process. To support the learning process, the textbook should be appropriate to the 2013 curriculum. This research used content analysis. The objectives of this research are (1) to explain the topics of writing materials in Bahasa Inggris textbook (2) to explain the writing materials written in Bahasa Inggris textbook (3) to explain the relatedness between writing materials and the K13 curriculum. Here, the result of this research shows that (1) The topic of writing material is appropriate to the 2013 curriculum. (2) The form of writing tasks meet as good criteria because the textbook gave good guideline and explanation exactly in social function, text structure and language feature. (3) The writing material in Bahasa Inggris textbook is related to the English 2013 curriculum because the writing material in the textbook have implemented based on the content of the syllabus of the 2013 curriculum. This textbook is good to use because it is suitable for students in Senior High School for the twelfth grade to increase their writing skills.

Keywords : Content analysis, writing material, 2013 curriculum
DESIGNING READING MATERIAL BASED ON BATAKNESE FOLKLORE
Authors: Sitompul Elen , Situmorang Hotmauli , Sipayung Rika , Siburian Uni 
Published: February 2022

Abstract

The low level of reading comprehension and interest affects their learning motivation at school. Many students are not interested in reading, because they think it is boring. To overcome these problems, this research aims: first, to develop Batak folklore. Second, to determine the effect of Batak folklore on reading comprehension and student motivation. This study takes 3 Batak folklore including 1) The Legend of Pohon Aren, 2) The Legend of Aek Situmandi, 4) The Legend of Air Soda.
This type of research is a qualitative descriptive obtained in writing to describe the moral values and character formation contained in the 3 Batak folk tales. The data of this research were taken from students of SMK Telkom Medan. Data collection is done by reading the story text over and over again. From the research, it can be concluded that Batak folklore can increase students' interest in reading and can be a motivation for every student.

Keywords: Batak folklore, motivation, reading interesting
Cardiovascular Risk in Patients with Rheumatoid Arthritis
Authors: Хамраев Х.Х. , Абдиев К.М. 
Published: February 2022

Цель. Изучить сердечно-сосудистый риск по шкале mSCORE у пациентов с ревматоидным артритом. Материалы и методы. Были обследованы 140 пациентов с РА в возрасте от 35 до 60 лет. Диагноз ревматоидного артрита был поставлен на основе критериев ACR (1987) и ACR/EULAR (2010). Для раннего выявления и прогнозирования сердечно-сосудистого риска использовалась шкала mSCORE (SCORE/EULAR). Результаты. У пациентов с РА наследственные факторы риска (ФР) для сердечно-сосудистых заболеваний были выявлены у 31,4%, абдоминальное ожирение у 35%, АГ у 63,6%, ГХС у 25,7% игиподинамия у 37,9% пациентов. Курили 10,8% пациентов в исследовании, так как большинство (82%) обследуемых были женщины. При этом АГ наблюдалась в 1,5 раза, ГХС в 2,1 раза чаще у мужчин, чем у женщин. Согласно результатам исследования по шкале mSCORE низкий риск был у 52 (37,1%), средний риск у 64 (45,7%), высокий риск был у 14 (10%), а очень высокий риск у 10 (7,2%) пациентов. Заключение. У пациентов с РА применение шкалы mSCORE дает возможность ранней диагностики сердечно-сосудистого риска и своевременной коррекции факторов риска.
Purpose. To study cardiovascular risk on the mSCORE scale in patients with rheumatoid arthritis (RA). Materials and methods. We examined 140 RA patients aged from 35 to 60 years. The diagnosis of rheumatoid arthritis was made on the base of the ACR (1987) and ACR/EULAR (2010) criteria. The mSCORE scale (SCORE/EULAR) was used for early detection and prediction of cardiovascular risk. Results. In patients with RA, hereditary risk factors (RF) for cardiovascular diseases were detected in 31.4%, abdominal obesity - in 35%, arterial hypertension (AH) - in 63.6%, hypercholesterolemia - in 25.7%, and hypodynamia - in 37.9% of patients; 10.8% of patients were smoking, the majority (82%) of the surveyed patients were women. At the same time, AH was observed 1.5 times more often, hypercholesterolemia - 2.1 times more often in men than in women. According to the results of the study on the mSCORE scale, 52 (37.1%) patients had low risk, 64 (45.7%) patients had average risk, high risk was in 14 (10%) patients, and a very high risk was in 10 (7.2%) patients. Conclusion. In RA patients, the use of the mSCORE scale gives the opportunity of early diagnostics of cardiovascular risk and timely correction of risk factors.
Antithrombotic and Anticoagulant Therapy in Patients with Peripheral Arterial Disease
Authors: Янушко В.А. , Роговой Н.А. , Климчук И.П. , Кордзахия Г.Э. 
Published: February 2022

Распространенность атеросклеротического поражения периферических артерий увеличивается в глобальных масштабах, и объем ресурсов системы здравоохранения, необходимый для лечения данного заболевания, неуклонно растет. Заболевания периферических артерий (ЗПА) синдромокомплекс, объединяющий различные по этиопатогенезу заболевания, в основе которых находится постепенное, нарастающее снижение артериального кровообращения в тканях. В последние годы наблюдается неизменный рост общего числа вмешательств при ЗПА. Изменения демографической ситуации, развитие технологий и расширение базы данных о результатах исследований на эту тему являются основными факторами, оказывающими влияние на принятие клинических решений при ЗПА. Лечение ЗПА требует мультидисциплинарного подхода и включает в себя работу специалистов различного профиля: сосудистых и кардиохирургов, кардиологов, рентгеноэндоваскулярных хирургов, эндокринологов. Реконструктивные хирургические вмешательства могут эффективно улучшить качество жизни пациентов, спасти конечность от ампутации и продлить жизнь. Однако для хороших отдаленных результатов необходима адекватная медикаментозная терапия. Анализ результатов исследований COMPASS и VOYAGER PAD продемонстрировал, что добавление ривароксабана 2,5 мг 2 раза в день к ацетилсалициловой кислоте уменьшает риск неблагоприятных ишемических событий со стороны конечности. Полученные данные предоставляют новые возможности применения консервативной терапии с целью сохранения проходимости шунтов, тем самым снижения риска развития критической ишемии и потери конечности.
The incidence of peripheral arterial atherosclerotic disease continues to increase globally and the amount of health care resources necessary for treatment of this disease is steadily increasing. There has been a steady increase of the total number of peripheral arterial disease (PAD) interventions in recent years. Changes in demographics, advances in technology, and an expanding database of research findings on this topic are the major factors that influence clinical decision-making in PAD. Treatment of PAD is multidisciplinary, and it includes the work of cardiovascular specialists. PAD represents itself from asymptomatic manifestations to critical ischemia of the lower extremities. Reconstructive surgery may effectively improve a patient’s quality of life, save the limb from amputation, and prolong life. However, adequate drug therapy is required for good long-term results. Long-term use of dual antiplatelet therapy or use of vitamin K antagonists are not indicated for PAD. Analysis of the results of the COMPASS and VOYAGER PAD studies demonstrated that the addition of rivaroxoban 2.5 mg twice daily to acetylsalicylic acid reduces the risk of adverse ischemic events in the limb. The obtained data provide new opportunities of conservative therapy in order to preserve the patency of bypass grafting, thereby reducing the risk of critical ischemia and losing limb.
The Fight against Arterial Hypertension is an Important Stage of the Preventive Continuum in Primary Health Care
Authors: Павлова О.С. , Пацеев А.В. , Кисель И.В. , Ливенцева М.М. , Нечесова Т.А. 
Published: February 2022

В Республике Беларусь начиная с 1995 года действует единая система раннего выявления пациентов с артериальной гипертензией (АГ), разработаны и внедрены в практическое здравоохранение новые методы профилактики и динамического наблюдения. Проанализирована эффективность мероприятий по выявлению и диспансеризации пациентов с АГ за период 2009-2020 гг. Выявляемость АГ увеличилась с 2009 г. на 21,8%. Число пациентов с АГ, находящихся под динамическим диспансерным наблюдением, возросло на 84,5%. Раннее выявление пациентов с АГ и внедрение современных схем антигипертензивной терапии привело к снижению показателя смертности от неосложненной АГ на 82,6% и цереброваскулярных заболеваний - на 23,1% за период с 2009 по 2019 г., количество случаев острых нарушений мозгового кровообращения у диспансерных пациентов с АГ уменьшилось на 40% с 2009 по 2020 г. Разработанная новая система первичной профилактики АГ с применением персонализированного подхода, и внедрение ее в качестве пилотного проекта в амбулаторно-поликлиническом учреждении за 5 лет позволило провести мониторинг факторов сердечно-сосудистого риска иповысить осведомленность об их наличии среди пациентов без болезней системы кровообращения для проведения углубленного профилактического консультирования, увеличить выявляемость неосложненной АГ в 1,8 раза для лечения заболевания на ранних этапах.
In the Republic of Belarus, since 1995, there has been a unified system for early detection of patients with arterial hypertension (AH); new methods of prevention and dynamic observation have been developed and introduced into practical health care. The effectiveness of measures of screening and dispensary observation of patients with AH for the period 2009-2020 was analyzed. The detection rate of AH has increased since 2009 by 21.8%. The number of hypertensive patients under dynamic dispensary observation has increased by 84.5%. Early detection of patients with AH and implementation of current antihypertensive therapy led to decrease of mortality rate from uncomplicated AH by 82.6% and cerebrovascular diseases - by 23.1% over the period from 2009 to 2019. The number of cases of acute disorders of cerebral circulation has decreased by 40% from 2009 to 2020 in dispensary patients with AH. The developed new system of primary prevention of AH and its implementation as a pilot project at the outpatient clinic for 5 years let to monitor cardiovascular risk factors and raise awareness of their presence in patients without cardiovascular system diseases for in-depth preventive counseling, to increase the detection rate of uncomplicated AH by 1.8 times for treatment of the disease at early stages.