bluuebunny/crossref_metadata_2025_split huggingface dataset:
Políticas públicas contra la mortalidad materna en Colombia
Authors: GOENAGA CARDENAS Nasly , DÍAZ-BARRIOS Jazmín 
Published: November 2022

La Mortalidad materna tiene impacto social tanto en el ámbito Internacional, como nacional, constituyéndose en un problema de salud pública y poniendo en evidencia las inequidades en salud. Este trabajo reflexiona sobre los esfuerzos que se realizan en Colombia para disminuir en cada región, la mortalidad materna. Metodológicamente, es una investigación cualitativa con revisión documental, análisis de contenido y hermenéutica como herramientas de recolección y procesamiento de información. Se revisaron los diferentes instrumentos de política pública existentes en Colombia para hacer frente al problema [Constitución, Leyes 715 (2001), 1122 (2007), 1438 (2011), 1841 (2013) y 1751(2015), entre otros], igualmente, la infraestructura en salud para apoyar la ejecución. Se encontró que existe un soporte legal orientado a preservar la vida materna, así como rutas de atención integral para esta población, pero los resultados muestran grandes diferencias en las cifras de las distintas zonas del país. Siendo un problema multifactorial, los determinantes sociales juegan un papel preponderante y la prestación de servicios, sobre todo en las zonas más deprimidas del país es compleja, requiriendo una intervención intersectorial en esos determinantes sociales y un fortalecimiento en el control de la gestión en la política pública, si se quiere que las cifras positivas abarquen todo el país y no sigan escondiendo profundas inequidades.
The Effect of Polybrene on an aPTT-based Lupus Anticoagulant Test in the Plasma of Patients Receiving Unfractionated Heparin
Authors: Kongkan Chulalak , Srinoun Kanitta , Kaewmaneerat Titirat , Penglong Tipparat 
Published: November 2022

Objective: Heparins can interfere with lupus anticoagulant (LA) testing, especially when the detection assays do not contain a heparin neutralizer. In this study we evaluated whether hexadimethrine bromide commonly known as polybrene was able to neutralize the effects of unfractionated heparin (UFH) on activated partial thromboplastin time (aPTT)-based LA determination. Material and Methods: The influence of polybrene on the aPTT-based LA testing results of 14 patients receiving UFH therapy was studied. Measurements were performed using Dade Actin FSL (aPTT-LA screen) and Dade Actin FS (aPTT-LA confirm) reagents on a Sysmex CS-1600 analyzer. The aPTT-LA screen/confirm ratios before and after the polybrene treatments were compared. Results: The UFH treatment affected the aPTT-LA screen/confirm ratio in four patterns, 1) no coagulation (NC code), 2) false positive, 3) false low, and 4) unchanged interpretation. After adding polybrene in the patient plasmas, the aPTT-LA screen/confirm ratios returned nearly to baseline without false positive or negative results. Conclusion: The best practice for LA testing should be done outside anticoagulant therapies, but if necessary, the tests can be performed by adding the proper concentration of polybrene.
From white to blue light: evolution of endoscope-assisted intracranial tumor neurosurgery and expansion to intraaxial tumors
Authors: Ruzevick Jacob , Cardinal Tyler , Pangal Dhiraj J. , Bove Ilaria , Strickland Ben , Zada Gabriel 
Published: November 2022

OBJECTIVE
Intraoperative use of the endoscope to assist in visualization of intracranial tumor pathology has expanded with increasing surgeon experience and improved instrumentation. The authors aimed to study how advancements in endoscopic technology have affected the evolution of endoscope use, with particular focus on blue light–filter modification allowing for discrimination of fluorescent tumor tissue following 5-ALA administration.

METHODS
A retrospective analysis of patients undergoing craniotomy for tumor resection at a single institution between February 2012 and July 2021 was performed. Patients were included if the endoscope was used for diagnostic tumor cavity inspection or therapeutic assistance with tumor resection following standard craniotomy and microsurgical tumor resection, with emphasis on those cases in which blue light endoscopy was used. Medical records were queried for patient demographics, operative reports describing the use of the endoscope and extent of resection, associations with tumor pathology, and postoperative outcomes. Preoperative and postoperative MR images were reviewed for radiographic extent of resection.

RESULTS
A total of 52 patients who underwent endoscope-assisted craniotomy for tumor were included. Thirty patients (57.7%) were men and the average age was 52.6 ± 16.1 years. Standard white light endoscopes were used for assistance with tumor resection in 28 cases (53.8%) for tumors primarily located in the ventricular system, parasellar region, and cerebellopontine angle. A blue light endoscope for detection of 5-ALA fluorescence was introduced into our practice in 2014 and subsequently used for assistance with tumor resection in 24 cases (46.2%) (intraaxial: n = 22, extraaxial: n = 2). Beyond the use of the surgical microscope as the primary visualization source, the blue light endoscope was used to directly perform additional tumor resection in 19/21 cases as a result of improved fluorescence detection as compared to the surgical microscope. No complications were associated with the use of the endoscope or with additional resection performed under white or blue light visualization.

CONCLUSIONS
Endoscopic assistance to visualize intracranial tumors had previously been limited to white light, assisting mostly in the visualization of extraaxial tumors confined to intraventricular and cisternal compartments. Blue light–equipped endoscopes provide improved versatility and visualization of 5-ALA fluorescing tissue beyond the capability of the surgical microscope, thereby expanding its use into the realm of intraaxial tumor resections.
The transfrontal isthmus approach for insular glioma surgery
Authors: Sun Guo-Chen , Shu Xu-Jun , Zheng Xiao-Que , Ma Xiao-Dong , Cheng Gang , Liu Jia-Lin , Chen Ling , Zhang Jian-Ning 
Published: November 2022

OBJECTIVE
The classic transopercular or transsylvian approach to insular gliomas removes the tumor laterally through the insular cortex. This study describes a new anteroposterior approach through the frontal isthmus for insular glioma surgery.

METHODS
The authors detailed the surgical techniques for resection of insular gliomas through the transfrontal isthmus approach. Fifty-nine insular gliomas with at least Berger-Sanai zone I involvement were removed with the new approach, and extent of resection and postoperative neurological outcomes were assessed.

RESULTS
Fifty-nine patients were enrolled in the study, including 35 men and 24 women, with a mean (range) age 44.3 (19–75) years. According to the Berger-Sanai classification system, the most common tumor was a giant glioma (67.8%), followed by involvement of zones I and IV (18.6%). Twenty-two cases were Yaşargil type 3A/B, and 37 cases were Yaşargil type 5A/B. The average angle between the lateral plane of the putamen and sagittal line was 33.53°, and the average width of the isthmus near the anterior insular point was 33.33 mm. The average angle between the lateral plane of the putamen and the sagittal line was positively correlated with the width of the isthmus near the anterior insular point (r = 0.935, p < 0.0001). The median (interquartile range [IQR]) preoperative tumor volume was 67.82 (57.64–92.19) cm3. Of 39 low-grade gliomas, 26 (66.67%) were totally resected; of 20 high-grade gliomas, 19 (95%) were totally resected. The median (IQR) extent of resection of the whole group was 100% (73.7%–100%). Intraoperative diffusion-weighted imaging showed no cases of middle cerebral artery– or lenticulostriate artery–related stroke. Extent of insular tumor resection was positively correlated with the angle of the lateral plane of the putamen and sagittal line (r = −0.329, p = 0.011) and the width of the isthmus near the anterior insular point (r = −0.267, p = 0.041). At 3 months postoperatively, muscle strength grade exceeded 4 in all cases, and all patients exhibited essentially normal speech. The median (IQR) Karnofsky performance score at 3 months after surgery was 90 (80–90).

CONCLUSIONS
The transfrontal isthmus approach changes the working angle from lateral-medial to anterior-posterior, allowing for maximal safe removal of insular gliomas.
Pengaruh PENGARUH PERILAKU KONSUMEN DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN MIE INSTAN MEREK SEDAP DI DESA MEDAN ESTATE
Authors: Sinurat Riomas , Sinurat Jefri 
Published: November 2022

Penelitian ini menggunakan explanatory research. Pada akhirnya hasil penelitian ini menjelaskan hubungan pengaruh perilaku konsumen dan promosi terhadap Keputusan Pembelian melalui pengujian hipotesis. Populasi penelitian ini adalah masyarakat Desa Medan yang mengkonsumsi produk Mie Instan Merek Sedap dengan sampel sebanyak 45 responden yang diambil dengan cara purposive sampling. Dalam penelitian ini untuk memperoleh data, peneliti menggunakan teknik pengumpulan data dengan menggunakan kuesioner. Uji instrumen dengan menggunakan uji validitas dan uji reliabelitas. Teknik analisis data menggunakan analisis regresi linear berganda. Data yang dihasilkan diolah dengan menggunakan program SPSS 16.0 for windows.
Dari hasil penelitian diketahui bahwa hasil regresi linier berganda dalam penelitian ini adalah sebagai berikut : Y = 2.167 + 0.355X1 + 0,356X2 + . Hasil Uji T menunjukkan bahwa variabel Perilaku Konsumen berpengaruh signifikan terhadap keputusan pembelian konsumen secara parsial, hal ini dapat dilihat dari sig. 0,000 < 0,05 dan nilai thitung (3,827) > ttabel (1,68) serta variabel Promosi berpengaruh signifikan terhadap keputusan pembelian konsumen secara parsial, hal ini juga dapat dilihat dari sig. (0,014) < 0,05 dan nilai thitung (2,577) > ttabel (1,68). Hasil uji F menunjukan bahwa Fhitung (16,258) > Ftabel (3,22) pada α = 0,05 dan tingkat signifikansi 0,000 < 0,05 yang artinya perilaku konsumen (X1) dan promosi (x2) secara simultan memiliki pengaruh yang signifikan terhadap keputusan pembelian (Y) dapat. Hubungan antara variabel keputusan pembelian dengan variabel perilaku konsumen dan promosi adalah erat. Hal ini didapat dari nilai Adjusted R Square sebesar 0,436 (43,6%) yang berarti sebesar 43,6 % variabel dari keputusan pembelian dijelaskan oleh variabel bebas yaitu perilaku konsumen dan promosi.
KEPUASAN AKADEMIK MAHASISWA PADA PENERAPAN KUALITAS PELAYANAN (STUDI KASUS PADA FAKULTAS EKONOMI UNIVERSITAS LANCANG KUNING) PEKANBARU
Authors: N Arizal , Listihana Wita dwika 
Published: November 2022

Tujuan penelitian ini untuk mengetahui secara empiris bagaimanana pengaruh dari kualitas pelayanan akademik yanag diberikan pihak pengelola jasa kepada pelanggananya dalam hal ini adalah mahasiswa pada Fakultas Ekonomi Universitas lancan Kuning.
Metode penelitian yang digunakan adalh metode deskriptif dengan disain penelitian kuantitatif. Pada pnenelitian ini mengunakan data skunder dan data primer. Populasi dalam penelitian iniadalah seluruh mahasiswa Fakultas Ekonomi Universitas Lancang Kuning yang aktif. Junlah dampel dalam penelitian ini adalah 200 orang. Teknik pengambilan sampel adalah dengan dengan menggunakan metode porpusive sampling, yaitu mahasiswa yang berada disemester genap. Alat analisis data adlah dengan menggunakan SPSS.
Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan antara kualitas pelayanan terhadap kepuasan. Sedangkan dari hasil R Square menunjukkan bahwa kontribusia variabel kualitas pelayanan
CONTROLLABILITY OF FREDHOLM’S INTEGRO-DIFFERENTIAL EQUATIONS WITH BY A DEGENERATE KERNEL IN HILBERT SPACES
Authors: Zhuravlov V. , Gongalo N. , Slusarenko I. 
Published: November 2022

The work examines integro-diﬀerential equations Fredholm with a degenerate kernel with Hilbert control spaces.

The need to study these equations is related to numerous ones applications of integro-
diﬀerential equations in mathematics, physics, technology, economy and other ﬁelds. Complexity the study of integro-diﬀerential equations is connected with the fact that the integral-diﬀerential operator is not solvable everywhere.

There are diﬀerent approaches to the solution of not everywhere solvable linear operator
equations: weak perturbation of the right-hand side of this equation with further application of the Vishyk-Lyusternyk method, introduction to system of impulse action, control, etc.
The problem of obtaining coeﬃcient conditions of solvability and analytical presentation
of general solutions of integro-diﬀerential equations is a rather diﬃcult problem, so frequent solutions will suﬃce are obtained by numerical methods.
In this connection, Fredholm’s integro-diﬀerential equations with degenerate kernel and
control in Hilbert spaces no were investigated. Therefore, the task of establishing conditions is urgent controllability, construction of general solutions in an analytical form and corresponding general controls of integro-diﬀerential equations with a degenerate kernel in abstract Hilbert spaces.
As an intermediate result in the work using the results of pseudoinversion of integral
operators in Hilbert spaces the solvability criterion and the form of general solutions are established integro-diﬀerential equations without control in the abstract Hilbert spaces.
To establish the controllability criterion is not solvable everywhere integro-diﬀerential equations with Hilbert control spaces, the general theory of research is not applied everywhere solvable operator equations. At the same time, they are used signiﬁcantly orthoprojectors, pseudo-inverse operators to normally solvable ones operators in Hilbert spaces.
With the use of orthoprojectors, pseudo-inverse operators and pseudoinversion of integraloperators, a criterion is obtained solutions and the general form of solutions of integro-diﬀerential equations with a degenerate kernel with control y Hilbert spaces. An image of the general appearance is obtained control under which these solutions exist.
PENGEMBANGAN MULTIMEDIA INTERAKTIF BERBASIS MACROMEDIA FLASH PADA MATERI IPA SEKOLAH DASAR
Authors: Sylvia Lara Syaflin  
Published: November 2022

Pengintegrasian teknologi dalam pembelajaran menjadi topik yang sangat menarik untuk di kembangkan sejalan dengan era revolusi industry 4.0. Disisi lain, pemanfaatan teknologi dalam pembelajaran masih sangat minim sekaitan dengan penguasaan literasi teknologi bagi para guru di Indonesia. Penelitian ini bertujuan untuk menghasilkan Multimedia Interaktif pada mata pelajran IPA yang valid, praktis dan memiliki efek potensial terhadap hasil belajar siswa kelas V di SD Negeri 34 Palembang. Prosedur penelitian menggunakan model Rowntree yang memiliki tiga tahap, yaitu: perencanaan, pengembangan, dan evaluasi. Evaluasi yang digunakan adalah evaluasi formatif Tessmer. Hasil penelitian dari validasi aspek materi, media, dan desain pembelajaran menunjukkan bahwa multimedia interaktif ini valid. Pada tahap uji one-to-one, siswa yang dijadikan subjek penelitian memberikan respon sangat baik terhadap multimedia interaktif yang digunakan. Pada tahap uji coba small group dengan kategori praktis. Pada tahap field test dengan skor 81,22 dalam kategori sedang. Berdasarkan hasil penelitian dapat disimpulkan bahwa multimedia interaktif yang dikembangkan dalam penelitian ini terbukti valid, praktis, dan memiliki efek potensial terhadap hasil belajar siswa dalam pembelajaran IPA di Sekolah Dasar.
PENGEMBANGAN BAHAN AJAR TEMATIK UNTUK PEMBELAJARAN BLENDED LEARNING BERBANTUAN APLIKASI NEARPOD DI KELAS III SEKOLAH DASAR
Authors: Elvinas Rini , Erita Yeni 
Published: November 2022

Bahan ajar merupakan kumpulan beberapa materi pembelajaran yang memuat berbagai langkah dan prosedur pembelajaram dan berguna untuk menciptakan suasana kelas yang menyenangkan. Penelitian ini bertujuan untuk mengembangkan bahan ajar tematik untuk pembelajaran blended learning berbantuan aplikasi Nearpod di kelas 3 Sekolah Dasar. Metode yang digunakan penelitian ini adalah metode R&D. Subjek penelitian ini adalah kelas III SDIT Padang Islamic School Kota Padang semester ganjil tahun pelajaran 2021/2022. Hasil penelitian menunjukan pada tahap pengembangan, evaluasi ahli terhadap buku teks mendapat skor 0,99% dalam materi, 0,86% dalam media, dan 1,06% dalam bahasa kategori yang valid. Tahap implementasi dilakukan dengan uji kepraktisan dan uji keefektifan. Tes kepraktisan guru mendapat skor 0,85% dalam kategori sangat praktis, dan tes kepraktisan siswa mendapatkan skor 0,85% dalam kategori sangat praktis. Uji keefektifan dilakukan di SDIT Madrasah Padang dan SDN 21 Lubuk Lintah Kota Padang terhadap hasil belajar siswa ditinjau dari pengetahuan dan mencapai nilai prediksi baik sebesar 84,44 dan 83,33. Keterampilan mendapat skor 3,63 dan 3,44, predikat sangat baik dan baik, dan skor sikap 3,67 dan 3,50, predikat sangat baik. Kesimpulan dari penelitian ini ialah pembelajaran blended learning berbantuan aplikasi Nearpod layak digunakan untuk menunjang hasil belajar peserta didik, dengan kategori valid, praktis dan efektif untuk digunakan di kelas 3 Sekolah Dasar.
A Multisystem Mitochondrial Disease Caused by a Novel MT-TL1 mtDNA Variant: A Case Report
Authors: Giannese Domenico , Montano Vincenzo , Lopriore Piervito , Nesti Claudia , LoGerfo Annalisa , Caligo Maria Adelaide , Dal Canto Flavio , Pasquinelli Gianandrea , Bonadio Angelo Giovanni , Moriconi Diego , Siciliano Gabriele , Mancuso Michelangelo 
Published: November 2022

Background: Mitochondrial tRNA (MTT) genes are hotspot for mitochondrial DNA mutation and are responsible of half mitochondrial disease. MTT mutations are associated with a broad spectrum of phenotype often with complex multisystem involvement and complex genotype-phenotype correlations. MT-TL1 mutations, among which the m.3243A>G mutation is the most frequent, are associated with myopathy, maternal inherited diabetes and deafness, MELAS, cardiomyopathy, and focal segmental glomerulosclerosis. Case study: Here we report the case of an Italian 49-years old female presenting with encephalomyopathy, chronic proteinuric kidney disease and a new heteroplasmic m.3274_3275delAC MT-TL1 gene mutation. Conclusions: Our case demonstrates a systemic mitochondrial disease caused by the heteroplasmic m.3274_3275delAC MT-TL1 gene mutation, not yet described in the literature. A mitochondrial disease should be suspected in case of complex multisystem phenotypes, including steroid-resistant nephrotic syndrome with multisystemic involvement.
Differential expression of key CmPn members distinguishes histological and immune subtypes of hepatic cancers
Authors: Abou-Fade Johnathan , Reid Victoria , Le Alexander , Zhang Jun 
Published: November 2022

Liver cancer, the sixth most diagnosed cancer worldwide is the third most common cause of cancer related deaths. The two most prevalent diagnosed subtypes include Hepatocellular carcinoma (HCC) and Cholangiocarcinoma (CCA) which comprise about 75% and 12-15% of all liver cancer cases, respectively. The liver is known to be a primary target and metabolic organ of the sex steroid hormone progesterone (PRG), which can induce its effects through either classic nuclear PRG receptors (nPRs), non-classic membrane PRG receptors (mPRs), or combined responses. In our previous studies we have demonstrated that the CCM signaling complex (CSC) couples both nPRs and mPRs to form the novel CmPn signaling network, which is involved in multiple cellular signaling pathways including angiogenesis and tumorigenesis of multiple cancers including breast cancers. Utilizing RNAseq data and Immunofluorescence approaches, we investigated the CmPn network to measure alterations to key cancer pathways during liver tumorigenesis by examining expression profiling for key CmPn members across multiple liver cancer subtypes, at both the transcriptional and translational levels. Our results demonstrated significant differential expression for multiple members of the CmPn signaling network including CCM1, PAQR7, PGRMC1, and nPRs, for both HCCs and CCAs, reinforcing the definitive roles of mPRs, nPRs, and CSC signaling during liver tumorigenesis. Therefore, we propose the future use of CmPn members’ expression data as potential prognostic hepatic cancer biomarkers or biomarker signatures to not only distinguish between two major subtypes, HCCs and CCAs, but also to define some rare subtypes, such as undifferentiated pleomorphic sarcoma (UPS) and hepatic angiosarcoma (HAS), which may lead to hopeful new therapeutic strategies for hepatic cancers.
Dominants of Regional Topos in the Artist’s Biography
Authors: Mykulanynets Lesia 
Published: November 2022

The purpose of the article is to define the key dominants of territorial topos and to reveal the specifics of their transmission to the artist’s biography. The research methodology is based on implementing the systemic approach by means of using a range of the following methods: the analytical method was used to grasp culture studies, philology, and arts studies sources in accordance with the paper issue; the philosophical method enabled considering biography within ontological discourse; the biographic method was used to characterise various domains of the artist’s being; the interdisciplinary method made it possible to comprehensively study the issue under consideration and obtain modern knowledge; the hermeneutic method was used to analyse the texts of the chronicles and to distinguish the typical features; the theoretical generalisation was used to summarise the research results. The scientific novelty lies in the fact that for the first time the author has revealed the key features of regional topos conceptualized by the master’s biography. Conclusions. Topos is an important paradigm of humanitarian studies reflecting the fundamental time and spatial ideas of macro-space and its laws. Regional topos is a form of image-bearing extention of questions referring to a certain territory, detailing its multifaceted nature, manifestation of its historical, civilisation, and social heritage. It restores valuable parameters of the locus’ being that have overcome various epochs and experienced different transformations but preserved stable codes, signs, symbols, as well as ethnic and professional traditions. Within the master’s biography, the aforementioned phenomenon is introduced by a complex of constituents where the predominant categories are as follows: “home” embraces the fundamentals of establishing the master’s world outlook, explains creativity issues, behaviour patterns; “childhood” reflects the image of happiness (or the wish to achieve it), trying to renew harmony, absolute love; “Small Motherland” implements the connection with native location revealing regional archetypes and specific mentality; “nature” demonstrates the unity of a person, matter, pantheistic restoring of strength, seeking the eternal creative themes, and the ability of occurring within cyclical time; “road” symbolises the content of the personality’s life path focused on eternity and spiritual immortality. The aforementioned toposes in chronicles give a key to understanding the master’s being. They do not function separately but interact, thus producing unique colouring and the sense colouration of the master’s ontology.
Key words: region, topos, regional topos, the artist’s biography.