bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl‐2 in hepatic stellate cells
Authors: Pang Huai , Wang Cuizhe , Ye Jing , Wang Lulu , Zhou Xiaoming , Ge Xiaomeng , Zhang Jun , Liu Qinghua 
Published: May 2022

AbstractHepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date. Hepatic stellate cells (HSCs) are the main cells involved in the formation of hepatic fibrosis, and induction of the apoptosis of HSCs is an important strategy for the treatment of hepatic fibrosis. Diallyl trisulfide (DATS) is a natural product and is the main active ingredient in garlic. However, the exact molecular mechanisms underlying HSC apoptosis induced by DATS are not well understood. This study aimed to analyze the efficiency and mechanism of DATS in hepatic fibrosis. Different concentrations (25, 50, 100, and 200 μM) of DATS were used to treat HSCs. Changes in cell morphology and formation of apoptotic bodies were observed under an inverted microscope and an electric microscope. Bcl‐2 signaling involving Bax, Caspase‐3, Caspase‐6, Caspase‐8, Caspase‐9, p53, Apaf‐1, and Cyto‐c in fibrosis were examined, which is a critical step in the evaluation of antihepatic fibrosis agents. We also evaluated the effect of DATS on the cellular morphology of HSCs and apoptosis‐related factors under different Bcl‐2 expression states. Our results suggest that DATS regulates hepatic fibrosis by blocking the Bcl‐2 signaling pathway and upregulating the Bax/Bcl‐2 ratio.
Sickle cell disease patients with COVID‐19 in Guadeloupe: Surprisingly favorable outcomes
Authors: Bernit Emmanuelle , Romana Marc , Alexis‐Fardini Scylia , Tarer Vanessa , Roger Pierre‐Marie , Doumdo Lydia , Petras Eléonore , Charneau Corine , Tressières Benoit , Dessources Marie Dominique Hardy , Etienne‐Julan Maryse 
Published: May 2022

AbstractWe investigate risk factors for hospitalization and difference between sickle cell syndromes in a cohort of COVID‐19 sickle cell disease (SCD) adult patients managed in the Reference Center of Guadeloupe. We retrospectively collected data of symptomatic SCD adult patients infected with SARS‐CoV‐2 between March and December 2020. Thirty‐eight SCD adult patients with symptomatic COVID‐19 infection were included during the first wave, representing 9.6% of the active patient file at our center. The median age (IQR) was 39 years (24–47). Four patients were obese and two had moderate renal failure. The median duration of symptoms (IQR) was 10 days (5–15). Seventeen (44.7%) patients were hospitalized, including two in intensive care unit (ICU) for acute chest syndrome. An 85‐year‐old SC patient with prostate cancer died. No difference was detected between inpatient and outpatient groups in terms of age, gender, BMI, SCD clinical complications, and in history SCD treatment. There was no difference for severity, hospitalization, length of stay, ICU stay, or death between SS or Sβ°‐thal patients and SC or Sβ+‐thal patients. These overall favorable outcomes among symptomatic patients may be related to the low prevalence of comorbidity known to be linked to the more severe forms of COVID‐19, but also to the prompt coordinated management of SCD patients in the Reference Center.
Extremely low arylsulfatase A enzyme activity does not necessarily cause symptoms: A long‐term follow‐up and review of the literature
Authors: Laugwitz Lucia , Santhanakumaran Vidiyaah , Spieker Mareike , Boehringer Judith , Bender Benjamin , Gieselmann Volkmar , Beck‐Woedl Stefanie , Bruchelt Gernot , Harzer Klaus , Kraegeloh‐Mann Ingeborg , Groeschel Samuel 
Published: May 2022

AbstractMetachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease caused by deficiency of arylsulfatase A (ARSA). Heterozygous carriers of disease‐causing variants and individuals harbouring pseudodeficiency alleles in the ARSA gene exhibit reduced ARSA activity. In the context of these genotypes, low ARSA activity has been suggested to lead to an atypical form of MLD or other neurological abnormalities, but data are limited. The aim of our study was to analyse the impact of low ARSA activity in two subjects who are heterozygous for the ARSA pseudodeficiency allele and a disease‐causing variant. Biochemical testing included ARSA activity measurements and urinary sulfatide analysis. Biochemical data of a large cohort of MLD patients, heterozygotes, pseudodeficient individuals and healthy controls were analysed. MRI was performed at 3T using T1‐ and T2‐weighted sequences and MR spectroscopy. We present two long‐term follow‐ups who are heterozygous for the ARSA pseudodeficiency allele and a disease‐causing variant in the ARSA gene in cis. The two related index cases exhibit markedly reduced ARSA activity compared to controls and heterozygous carriers. The neurological evaluation and MRI do not reveal any abnormalities. Our data underline that extremely low enzyme activity due to a pseudodeficiency allele and a disease‐causing variant in the ARSA gene even in cis does not lead to clinical symptoms or pre‐symptomatic MRI changes suspicious for MLD. The review of literature corroborates that any association of low ARSA activity with disease features remains questionable. It seems important to combine the measurement of ARSA activity with elevated sulfatide as well as genetic testing, as done in current newborn screening approaches. Heterozygosity for metachromatic leukodystrophy and an arylsulfatase A pseudodeficiency allele does not cause neurological or neuropsychiatric features.
Secondary cross infection with dengue virus serotype 2/3 aggravates vascular leakage in BALB/c mice
Authors: Qiu Lijuan , Huang Xinwei , Luo Jia , Zhao Yujiao , Hong Shan , Wang Xiaodan , Feng Kai , Pan Yue , Sun Qiangming 
Published: May 2022

AbstractDengue virus (DV) has occasionally emerged at epidemic levels in Yunnan, China. Vaccine development is limited by antibody‐dependent enhancement and a lack of good animal models. Thus, the study investigated cross infection based on maternal immunity in BALB/c mice and assessed the risk of cross infection by DV2‐D13113 and DV3‐YNWS2 epidemic virus strains. DV replicated within the organs of the BALB/c infant mice, even causing death. Particularly, DV3‐infected infant mice were at higher risk of severe disease if their mothers were infected with DV2. Although BALB/c adults and pups survived DV2/DV3 infection and produced anti‐DV antibodies after 5–8 days, extensive subcutaneous vascular leakage was observed after secondary DV infection. Furthermore, vascular permeability in the lung and kidney significantly increased in offspring born to heterotypic virus‐infected mothers. Thus, vascular leakage indicates severe DV infection. The results indicate that maternal immunity increases the severity of subsequent heterotypic infection. Additionally, secondary cross infection by D13113 and YNWS2 represents a risk of serious disease. This study has implications for studies of DV cross infection and vaccine development.
The colorful company: Effects of brand logo colorfulness on consumer judgments
Authors: Song Jiaqi (Flora) , Xu Fei (Katie) , Jiang Yuwei 
Published: May 2022

AbstractThis study examines the impact of brand logo colorfulness on consumer judgments toward a brand and its products. Four experiments demonstrate that the colorfulness of a brand logo affects consumers' perception of the product variety offered by the brand. When consumers feel that a brand logo is colorful, they tend to infer that the brand offers a high variety of product options to its customers. Driven by the perception of product variety, logo colorfulness has downstream consequences on consumer attitudes, an effect that can be moderated by brand positioning. Together, this study introduces the effects of logo colorfulness on consumer judgments, contributes to the psychological literature on color and variety, and bears important practical implications regarding how designers and marketers can practically determine a brand logo that best serves the brand image.
Analysis of numerical simulation models for the turbo air classifier
Authors: Yu Y. , Wang L. , Liu J. 
Published: May 2022

AbstractThe comparative analysis on the flow field of turbo air classifier, using different turbulence models and moving region calculation models, is completed based on ANSYS‐FLUENT. The simulation results show both RNG k‐ϵ and Reynolds stress models have the high calculation accuracy with the low computational cost. There are slightly different at the interface between the moving and static regions for multiple reference frame (MRF) model and sliding mesh (SM) model. However, the iteration number of multiple reference frame model is far less than that of sliding mesh model with the same calculation accuracy. Meanwhile, the flow field in the rotor cage channel is well‐distributed when air inlet velocity is close to the linear velocity at outer edge of rotor cage no matter what combination of the models is used among the RNG k‐ϵ model and Reynolds stress model together with multiple reference frame model and sliding mesh model. The classification experiments show the accuracy and the Newton classification efficiency are high when the air inlet velocity is 12 m/s and the rotating speed of rotor cage is 1200 min−1. The experimental results are consistent with simulation results of the flow field in the classifier.
Microstructure and mechanical properties of 1000 MPa grade steel plate for hydropower station in different quenching processes
Authors: Chen J. , Li C.S. , Ren J.Y. , Ke Y.J. , Cao Y. 
Published: May 2022

AbstractStrength and toughness of the ferrum‐1.2manganese‐1.4nickel steel plates in the DQT (direct quenching→tempering) and DQQT (direct quenching→reheated quenching→tempering) processes were investigated. This ferrum‐1.2manganese‐1.4nickel which possessed a relatively low alloy content and improved purity was used as the 1000 MPa grade high‐strength steel plates for hydropower station. The flat prior austenite grains with the dislocation density of 4.86×1014 m−2 and nano‐scaled precipitates were acquired in the DQT process. The grains and precipitates grew up and the dislocation density decreased to 4.26×1014 m−2 as a result of reheated quenching in the DQQT process. After tempering, the yield strength of the specimen treated by the DQT process was ∼996 MPa, which was ∼34 MPa higher than that of the DQQT sample. The difference of yield strength between these two quenching processes was primarily ascribed to grain boundary strengthening and partly caused by dislocation strengthening or precipitation strengthening. Due to the circular propagation path of cracks and matrix softening, the impact energy at −60 °C in the DQQT process was superior to that of the DQT process.
Ultrasound‐guided versus landmark‐guided subacromial corticosteroid injections for rotator cuff related shoulder pain: A systematic review of randomised controlled trials
Authors: Adamson Natasha J. , Tsuro Munyaradzi , Adams Nicola 
Published: May 2022

AbstractIntroductionRotator cuff related shoulder pain (RCRSP) is the most common presentation of shoulder pain within physiotherapy. Corticosteroid injections (CSI) have become increasingly popular to reduce pain, increase range of motion (ROM) and improve shoulder function. Evidence around the use of ultrasound‐guided (USG) versus landmark‐guided (LMG) CSIs remains controversial.ObjectiveThe objective of this appraisal was to compare the effectiveness of each approach in the management of RCRSP.MethodsCochrane, PubMed and CINAHL electronic databases were searched (from January 2014 to February 2021). Randomised controlled trials (RCTs) were included comparing USG to LMG CSIs for RCRSP. An independent reviewer selected the studies, extracted and synthesised the data. Two reviewers carried out a quality appraisal. Outcome measures were pain, function and ROM.ResultsFour RCTs (n = 179 participants, n = 184 shoulders) were reviewed. Both USG and LMG groups showed statistically significant within group improvements in clinical outcomes. There were no significant differences between groups. Three studies were identified as being a ‘low’ risk of bias (RoB) and did not favour the use of ultrasound. One study did favour the use of ultrasound for improving function, although it was found to have ‘high’ RoB. Adverse events were seldom reported.ConclusionThere is limited evidence to suggest using USG CSIs has a superior effect on clinical outcomes compared to LMG, though small sample sizes and lack of long‐term follow‐up limit the generalisability of the findings.
Results from an international interlaboratory study on light‐ and elevated temperature‐induced degradation in solar modules
Authors: Karas Joseph , Repins Ingrid , Berger Karl A. , Kubicek Bernhard , Jiang Fangdan , Zhang Daqi , Jaubert Jean‐Nicolas , Cueli Ana Belén , Sample Tony , Jaeckel Bengt , Pander Matthias , Fokuhl Esther , Koentopp Max B. , Kersten Friederike , Choi Jun‐Hong , Bora Birinchi , Banerjee Chandan , Wendlandt Stefan , Erion‐Lorico Tristan , Sauer Kenneth J. , Tsan Jon , Pravettoni Mauro , Caccivio Mauro , Bellenda Giovanni , Monokroussos Christos , Maaroufi Hamza 
Published: May 2022

AbstractThis paper reports the results of an international interlaboratory comparison study on light‐ and elevated temperature‐induced degradation (LETID) on crystalline silicon photovoltaic (PV) modules. A large global network of PV module manufacturers and PV testing laboratories collaborated to design a protocol for LETID detection and screen a large and diverse set of prototype modules for LETID. Results across labs indicate the reproducibility of LETID testing is likely within ±1% of maximum power (PMP). In intentionally engineered LETID‐sensitive modules, mean degradation after the prescribed detection stress is roughly 6% PMP. In other module types the LETID sensitivity is smaller, and in some we observe essentially negligible degradation attributable to LETID. In LETID‐sensitive modules, both open‐circuit voltage (VOC) and short‐circuit current (ISC) degrade by a roughly similar magnitude. We observe, as do previous studies, that LETID affects each cell in a module differently. An investigation of the potential mismatch losses caused by nonuniform LETID degradation found that mismatch loss is insignificant compared to the estimated loss of cell ISC, which drives loss of module ISC. Overall, this work has helped inform the creation of a forthcoming standard technical specification for LETID testing of PV modules, IEC TS 63342 ED1, and should aid in the interpretation of results from that and other LETID tests.
Using latent profile analysis to investigate emotional intelligence profiles in a sample of American university students
Authors: Thomas Christopher L. , Heath Joshua A. 
Published: May 2022

AbstractNumerous empirical investigations have explored the contribution of emotional intelligence to academic success. Although these studies have contributed to the literature, most have adopted variable‐centric analytic approaches that may mask our understanding of the nuanced association between emotional intelligence, noncognitive factors, and academic success. Therefore, the current study was designed to identify unique emotional intelligence profiles using latent‐class analysis. A convenience sample of university students (N = 432, 79.7% Caucasian, 80.62% female, 18–65 years old, Age = 21.55 ± 5.47) attending two public universities completed the Brief Emotional Intelligence Scale, Brief Cope Inventory, Inventory of School Motivation, Engagement Versus Disaffection with Learning Scale, Cognitive Test Anxiety Scale‐2nd Edition, and Perceived Stress Scale. The sample consisted of freshman (13.87%), sophomore (32.53%), junior (35.16%), senior (13.15%), and master's (5.26%) students. Using latent profile analysis, we identified four unique emotional intelligence profiles which differed along competencies identified in the ability model of emotional intelligence. Follow‐up analyses indicated that problem and social‐focused coping strategies, mastery orientation, and behavioral and emotional engagement contributed to the separation of students belonging to the identified profiles. Our discussion focuses on the importance of fostering emotional intelligence within higher education settings to support student success.
The recording of personality strengths: An analysis of the impact of positive personality features on the long‐term outcome of common mental disorders
Authors: Yang Min , Tyrer Peter , Tyrer Helen 
Published: May 2022

AbstractAlthough personality strengths are assessed frequently in occupational and managerial settings and in children, they have been less used in studies of personality disorder. The aim of this study is to examine the impact of a measure of personality strengths derived from the comprehensive version of the Personality Assessment Schedule (CPAS) (i.e., positive and reinforcing traits) on clinical symptoms and functioning. Eighty‐nine patients with anxiety and depression seen at the 30‐year follow‐up point in a cohort study (Nottingham Study of Neurotic Disorder) were administered the Comprehensive version of the PAS (CPAS). A factor analysis of the results determined the main groupings and their impact on long‐term outcomes as well as their association with change of outcomes over 30 years. Five positive factors (strengths), forceful considerateness, emotional toughness, cautiousness, independence and discernment accounted for 67.2% of the variance using both Varimax and Promax rotations. Low positive scores were strongly associated with suicide attempts, moderate/severe personality disorder, cothymia (mixed anxiety‐depression), greater symptomatology and poor social function. High scores were protective of serious pathology and particularly effective in inhibiting suicidal behaviour. The promotion of personality strengths may be of value in preventing suicidal behaviour and helping pro‐social change in those with personality disturbance.
Treatment and prognosis of pleuropulmonary blastoma: A single‐center report of 31 cases
Authors: Wang Fenghua , Zhuang Linwei , Liang Jianhua , Li Le , Wang Hui , Tang Jue , Zeng Jiahang , Liu Wei 
Published: May 2022

AbstractObjectivesPleuropulmonary blastoma (PPB) is a very rare and highly aggressive neoplasm occurring in children, mostly under 6 years of age. We assessed the clinical characteristics, treatment modalities, treatment outcomes, and prognostic factors affecting survival in patients with PPB treated at our institution over a 10‐year period to improve the prognosis.MethodsFrom November 2008 to November 2019, 31 children (21 boys and 10 girls) with a median age of 30 months (ranging, 22 days to 54 months) were treated at our institution. Here we describe the patient characteristics, treatment modalities, and treatment outcomes. The Kaplan–Meier method was used to estimate the progression‐free survival (PFS) and overall survival (OS). Log‐rank test was performed for comparison between groups.ResultsThree children were lost to follow‐up and two were dead due to postoperative complications. Of the 26 patients included in the follow‐up, 16 PPB patients displayed tumor‐free survival. The 5‐year PFS and OS were 60.4% and 60.1% respectively. By stratified statistical analysis, the 5‐year PFS and OS of type I PPB were 100%, while those of type III PPB were 43.7% and 43%, respectively. The 5‐year PFS and OS of complete tumor resection were 76.5% and 75.6%, respectively, while those with tumor residue were 31.3%. The 5‐year PFS and OS combined with chemotherapy were 62.2% and 61.6%, respectively, while those without chemotherapy were 0%.ConclusionsPPB is an aggressive neoplasm. The main factors related to the prognosis of PPB are pathological type, tumor resection degree, and postoperative adjuvant therapy.
Within the walls of the classroom: How science teachers' instruction can develop students' sociopolitical consciousness
Authors: Jones Britney L. , Taylor Jonte C. 
Published: May 2022

AbstractIn this paper, we synthesize existing literature on Culturally Relevant Science Teaching (CRST), more specifically the third tenet of CRST‐developing students' sociopolitical or critical consciousness. While there is research on this third tenet, our review of the literature reveals that this tenet is understudied and underutilized. We offer our conceptual framework and an illustrative example to demonstrate how teachers can practically implement the third tenet of CRST to engage and empower students in science. We hope that the ideas and examples shared in this piece will help teachers foster students' sense of sociopolitical consciousness and advocacy within the walls of the classroom and beyond. We also urge researchers to continue producing research on this important topic so that practitioners can use this information to develop students' sociopolitical/critical awareness, reflections, and actions.
Renewable energy project success: Internal versus external stakeholders' satisfaction and influences of power‐interest matrix
Authors: Maqbool Rashid , Rashid Yahya , Ashfaq Saleha 
Published: May 2022

AbstractStakeholders satisfaction, as well as an effective involvement, is of utmost importance for any mega project, when it comes to the public concerning projects this role becomes more essential. In the case of developing countries where the political, economic and administrative settings are challenging, managing all the key stakeholders satisfaction for prosperous projects becomes extremely intricated, no matter even it is about sustainable and renewable energy projects. Studies have been conducted on project governance and shareholder relationships, nevertheless, the role of power‐interest matrix in maximizing stakeholder satisfaction on renewable energy projects has not been fully explored in the literature. This research was attempted to investigate the direct and indirect influencing mechanisms of the stakeholders satisfaction in conjunction with five critical success factors (CSFs) (namely communication factors, team factors, technical factors, organizational factors and environmental factors) in the renewable energy projects. Alongside a direct link of the CSFs in renewable energy projects, an indirect influence of both the internal and external stakeholders satisfaction has been also checked in this research. A quantitative approach was used to collect the questionnaire survey based data from the professionals working in the renewable energy industry of Pakistan. A snowball sampling technique was used to collect a total of 565 valid responses from the professionals working on medium and large scale renewable energy projects. The structural equation modelling (SEM) technique was used to perform the data analysis and provide inferences between the direct impacts of CSFs and indirect influences of internal and external stakeholders satisfaction in the renewable energy projects. The first stage of the SEM analysis depicts the direct impacts of the CSFs on renewable energy projects. However, in the second stage, though the mediating role of internal stakeholders satisfaction was observed in between all the CSFs and project success, external stakeholders satisfaction was found to be significantly mediating only between the communication factors and environmental factors, and renewable energy project success. Though the findings provide useful guidelines for the professionals, policymakers and administrators that in order to have prosperous renewable energy projects the influence of both the internal and external stakeholders satisfaction is important alongside CSFs, however, the role of internal stakeholders satisfaction is more critical to consider for such sustainable projects.