bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subversion of the Oral Microbiota and Induction of Immune-Mediated Systemic
Inflammation with Special Reference to Periodontitis: Current
Knowledge and Perspectives
Authors: Santacroce Luigi , Muzio Eleonora Lo , Bottalico Lucrezia , Spirito Francesca , Charitos Ioannis Alexandros , Passarelli Pier Carmine , Jirillo Emilio 
Published: June 2022

Abstract:
Under steady-state circumstances, the oral microbiota is in equilibrium with host tissues,
thus contributing to local and systemic health. Any interruption of such equilibrium leads
to a condition of dysbiosis with the proliferation of oral pathogens able to cause gingivitis and
periodontal disease. The mechanisms of periodontitis will be described, mostly emphasizing the
noxious effects exerted by oral pathogens on the periodontium either directly or indirectly via the
release of an array of mediators, even including pro-inflammatory cytokines, chemokines, and
enzymes. The persistence of local inflammation ultimately leads to systemic inflammation; therefore,
the link between periodontitis and obesity, diabetes and cardiovascular disease will be elucidated.
Some natural compounds, such as polyphenols, prebiotics, and probiotics, will be discussed
for their ability to exert anti-inflammatory and anti-oxidant activities in the context of the
inflamed buccal cavity and systemically, as well as for their modulation of the altered gum-gut
microbiota.
Distribution of Leukocidins, Exfoliative Toxins, and Selected Resistance Genes Among Methicillin-resistant and Methicillin-sensitive Staphylococcus aureus Clinical Strains in Egypt
Authors: Elbargisy Rehab Mohammed 
Published: June 2022

Background:
Infection with Staphylococcus aureus (S.aureus) is an increasing health problem worldwide. This pathogen has multiple virulence factors that contribute to its pathogenesis in a wide range of diseases. The present study aimed to investigate the prevalence of leukocidins, exfoliative toxins, and common antimicrobial resistance genes among Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Sensitive Staphylococcus aureus (MSSA) strains collected from various clinical sources in Egypt.

Methods:
Isolates were identified as S.aureus by the standard microbiological methods. Methicillin resistance was detected phenotypically by cefoxitin disc diffusion method and genotypically by PCR for detection of mecA gene. PCR was also used to detect the presence of leukocidin genes (LukD, LukE, LukF-PV, and LukS-PV), exfoliative toxin genes (eta and etb), and antibiotic resistance genes (tetK, tetM, ermA, ermC, msrA, and aacA-aphD).

Results:
About 50.5% of tested isolates were methicillin resistant by cefoxitin disc assay, while mecA gene was amplified in 64.6% of isolates. The highest prevalent toxin gene was lukE (93%) and the least prevalent one was eta (1%). The resistance genes tetK and tetM were detected in nearly 50% of the tested strains but lower prevalence rates were recorded for aacA-aphD, msrA, ermA, and ermC genes.

Conclusion:
Methicillin resistance was highly prevalent among tested S.aureus strains. Regarding the studied virulence and resistance genes, no significant difference was detected between MRSA and MSSA strains, except for ermA gene p<0.05 which was highly prevalent in MRSA strains. So, the variation between MRSA and MSSA strains in the response to treatment may be attributed to the resistance of MRSA strains to all β-lactams in addition to other possible acquired resistance mechanisms. Accordingly, fewer options of antimicrobial medications are available to treat MRSA infections.
EFFICIENCY OF INSULINOTHERAPY OF DIABETES MELLITUS TYPE 1 IN CHILDREN AND ADOLESCENTS
Authors: Budreiko O. A. 
Published: June 2022

Analysis of the treatment of type-1 diabetes in children and adolescents in recent years has shown a significant increase in using of insulin analogues. Improvement in the compensation of carbohydrate metabolism and state of microcirculation on the background of the use of insulin analogues when compared with other insulin drugs is shown. The importance of maintaining stable blood glucose levels at night to prevent the development of microcirculatory disorders, which is ensured, primarily by the drugs of non-peak prolonged insulin action was proved.
INSULIN RESISTANCE INCIDENCE IN CHILDREN AND ADOLESCENTS WITH OBESITY
Authors: Budreiko O. A. , Nikitin L. D. , Chumak S. O. , Filipova N. V. , Yudchenko O. I. 
Published: June 2022

Examination of 186 children and adolescents with obesity has shown that insulin resistance according to HOMA index is revealed significantly more often (44,3 %) than carbohydrate metabolism disorders according to WHO criteria (5,9 %). Insulin resistance incidence in boys in early and late puberty as compared with prepuberty, increased 4 times. In girls it was registered only in puberty and was less frequent than in boys. It has been established that in children and adolescents with obesity insulin resistance incidence depends mostly not on the type of obesity (hypothalamic or exogenous constitutional) but on the degree of excess body weight.
EXPERIENCE OF THE THERAPY OF HYPOANDROGEN MALE INFERTILITY WITH TAMOXIFEN — AEVIT COMBINATION
Authors: Kozhemyaka V. A. , Bondarenko Volodymyr , Minuchin Andriy 
Published: June 2022

Studies into peculiar changes of spermatogram parameters, fructose content in ejuaculate and hormonal levels of hypophysic-gonadal system using the therapy of idiopathic pathospermias in hypoandrogenized males treated with Tamoxifen-Aevit combination have been performed. The applied therapy led to a profound improvement of spermatogram parameters, testosterone secretion stimulation, increased fructose concentration in ejaculate. Tamoxifen combined with Aevit had a more substantial influence upon normalization of all spermatogram parameters of infertile males when prior to their treatment the testosterone-luteinizing hormone ratio exceeded 2,0.
PECULIAR VARIATIONS OF THE INCRETORAL AND SPERMATOGENIC TESTICLE FUNCTION IN HYPOTHYROIDISM-AFFECTED MEN TREATED WITH L-THYROXIN
Authors: Bondarenko Volodymyr , Spivak Zh. S. , Zubko M. I. , Miroshnichenko A. V. 
Published: June 2022

The present study has been aimed at determining levels of thyroid-stimulating hormone, thyroxin, free and total testosterone in blood, spermatogram parameters in 20 reproductive men afflicted with primary hypothyroidism prior, following 1 and 3 months of L-thyroxin treatment. Upon completion of 3-month therapy average testosterone values were found to increase profoundly in blood. The spermatozoon amount in 1ml of ejaculate, the percentage of their active and viable forms raised considerably either. It has been revealed that these positive changes in testicles of patients with hypothyroidism take place with regard to the thyroid status compensation.
THERAPEUTIC CORRECTION OF AUTOIMMUNE THYROIDITIS FROM HYPOTHY HYPERTHUNCTION OF THE THYROID GLAND
Authors: Kravchun N. O. , Kozakov Alexandr , Chernyavska Irina 
Published: June 2022

The influence of the herbal drug "Zobofit" on the functional activity, structure, including focal changes, thyroid gland, as well as
indicators of autoimmunity in patients with autoimmune thyroiditis.
VITEFFECT OF NOOTROPIC AND NEUROPROTECTOR PRODUCTS PROPERTIES OF ENERGY METABOLISM PROCESSES AND MANIFESTATIONS OF MITOCHONDRIAL DYSFUNCTION IN THE NEURONS OF THE MAIN BRAIN OF RATS WITH ALOXAN DIAMIN D STATUS IN ADOLSECENTS WITH TYPE 1 DIABETES MELLITUS
Authors: Zhylyuk V. I. , Mamchur V. Y. , Pavlov S. V. , Bukhtiyarova N. V. 
Published: June 2022

In experimental studies in rats with chronic alloxan-induced hyperglycemia, it was found that the use of piracetam for 20 days,
pramiracetam and ginkgo biloba extract to varying degrees help to reduce the effects of mitochondrial dysfunction and energy deficiency in brain neurons. The basis of these mechanisms is the prevention of mitochondrial opening
cyclosporine-A-sensitive pores, reduction of mitochondrial transmembrane potential and increase of synthesis of macroergic phosphates. The most important
the effect under these conditions has pramiracetam.
HISTOFUNCTIONAL FEATURES OF VISCERAL ADHESIVE TISSUE THE DESCENDANTS OF GESTALLY STRESSED MOTHERS
Authors: Sergienko L. Yu. , Perets O. V. , Kartavtseva O. V. , Cherevko G. M. , Tolmachova L. M. , Bondarenko T. V. 
Published: June 2022

A comparative study of the histostructure of adipose tissue in females was performed rats - offspring of intact and gestational stressed mothers in the basal state and after the action of stress factors. It was found that the stress of mature offspring
leads to the formation of a hypertrophic type of obesity in intact animals and provokes adipocyte hyperplasia and adipose tissue inflammation in rats stressed during the antenatal period.
ADIPOCYTOKINES IN DEVELOPMENT INSULIN RESISTANCE IN OBESITY
Authors: Yarmysh N. V. , Kravchenko N. A. , Voitenko E. I. 
Published: June 2022

Adipose tissue is key regulator of energy balance and plays an active role in the accumulation of lipids,
as well as the synthesis and secretion of a wide range of adipokines that could potentially be involved in pathogenetic events associated with obesity
THE PROTECTIVE EFFECT OF QUERCETIN ON THE DEVELOPMENT OF METABOLIC SYNDROME IN THE OVARIECTOMIZED RATS FED WITH THE HIGH-FAT DIET
Authors: Borikov Oleksii 
Published: June 2022

The aim of the study was to investigate the impact of quercetin on the metabolic manifestations of insulin resistance syndrome induced by high-fat diet in rats under estrogen deficiency. It was revealed that treatment with quercetin ameliorated insulin resistance, decreased visceral fat mass and lipid peroxidation in serum and heart, increased endogen nitric oxide production and decreased ADP-induced platelet aggregation in the ovariectomized rats fed with the high-fat diet. These results show that the quercetin may be used for treatment of the cardio-vascular diseases in postmenopausalwomen.
Social activity in shaping the participatory budget
Authors: Dąbrowska Małgorzata 
Published: June 2022

In civil society, self-government as a form of social organisation occupies one of the central positions. The condition for the implementation of the development mission of local government is the participation of citizens and their co-responsibility for the shape of local social life. Recently, the participatory budget has become one of the most popular forms of participation. Its aim is to directly involve residents in the decision-making process regarding the choice of the scope of public tasks within the designated pool of funds and to take over part of the responsibility. The aim of the presented analysis is to show the dynamics of citizen involvement in consultations on spending part of the city budget on local tasks falling within the competence of local government – The civic budget. The adopted research hypothesis assumes that the participatory budget is the most popular form of consultation because in its formula it gives residents a sense of agency and subjectivity in expressing one’s opinions and preferences and also gives tangible results of social engagement visible in the short term. The empirical basis for the analysis are reports on the implementation of the participatory budget of the city of Radom from the beginning of its creation, and literature on the subject. A participatory budget is an excellent tool for education about self-government – it is an element of a specific philosophy of functioning of self-government – as a community of authorities and residents of a given territorial unit, cooperating for its development. The example of the city of Radom indicates that the participatory budget supports, complements, and often replaces or increases the efficiency of public administration. The analyses carried out can be an indication when improving the implementation of the budget of Mazovia.
Using Twitter Data for Cohort Studies of Drug Safety in Pregnancy: Proof-of-concept With β-Blockers
Authors: Klein Ari Z , O'Connor Karen , Levine Lisa D , Gonzalez-Hernandez Graciela 
Published: June 2022

Background
Despite the fact that medication is taken during more than 90% of pregnancies, the fetal risk for most medications is unknown, and the majority of medications have no data regarding safety in pregnancy.

Objective
Using β-blockers as a proof-of-concept, the primary objective of this study was to assess the utility of Twitter data for a cohort study design—in particular, whether we could identify (1) Twitter users who have posted tweets reporting that they took medication during pregnancy and (2) their associated pregnancy outcomes.

Methods
We searched for mentions of β-blockers in 2.75 billion tweets posted by 415,690 users who announced their pregnancy on Twitter. We manually reviewed the matching tweets to first determine if the user actually took the β-blocker mentioned in the tweet. Then, to help determine if the β-blocker was taken during pregnancy, we used the time stamp of the tweet reporting intake and drew upon an automated natural language processing (NLP) tool that estimates the date of the user’s prenatal time period. For users who posted tweets indicating that they took or may have taken the β-blocker during pregnancy, we drew upon additional NLP tools to help identify tweets that report their pregnancy outcomes. Adverse pregnancy outcomes included miscarriage, stillbirth, birth defects, preterm birth (<37 weeks gestation), low birth weight (<5 pounds and 8 ounces at delivery), and neonatal intensive care unit (NICU) admission. Normal pregnancy outcomes included gestational age ≥37 weeks and birth weight ≥5 pounds and 8 ounces.

Results
We retrieved 5114 tweets, posted by 2339 users, that mention a β-blocker, and manually identified 2332 (45.6%) tweets, posted by 1195 (51.1%) of the users, that self-report taking the β-blocker. We were able to estimate the date of the prenatal time period for 356 pregnancies among 334 (27.9%) of these 1195 users. Among these 356 pregnancies, we identified 257 (72.2%) during which the β-blocker was or may have been taken. We manually verified an adverse pregnancy outcome—preterm birth, NICU admission, low birth weight, birth defects, or miscarriage—for 38 (14.8%) of these 257 pregnancies. We manually verified a gestational age ≥37 weeks for 198 (90.4%) and a birth weight ≥5 pounds and 8 ounces for 50 (22.8%) of the 219 pregnancies for which we did not identify an adverse pregnancy outcome.

Conclusions
Our ability to detect pregnancy outcomes for Twitter users who posted tweets reporting that they took or may have taken a β-blocker during pregnancy suggests that Twitter can be a complementary resource for cohort studies of drug safety in pregnancy.
Nilai-Nilai Filosofis Edet Sumang dalam Masyarakat Linung Bulen II, Kecamatan Bintang, Aceh Tengah
Authors: Ayu Ningsih Khairum , Amin Husna 
Published: June 2022

The people of Kampung Linung Bulen II have a way of regulating their behavior and daily social arrangements by Islamic Shari'a values. One of them is Edet Sumang. This study aims to identify the history of the birth of Edet Sumang and its influence on the understanding of the people of Linung Bulen II, Bintang District, Central Aceh Regency. This is field research that uses descriptive research methods and a qualitative approach. primary data is obtained from interviews with predetermined informants, secondary data is obtained from the relevant literature. The results of the study show that Edet Sumang's philosophy is seen in the morals that govern people's lives, this rule is useful for guiding people's attitudes and behavior. Edet Sumang as pemeger (fence) and protector of society from things that are considered inappropriate (inappropriate). Efforts to maintain Edet Sumang are very important because Edet Sumang can have a positive influence on the lives of the people of Linung Bulen II, Bintang District, Central Aceh Regency.AbstrakMasyarakat Kampung Linung Bulen II mempunyai adat istiadat untuk mengatur pola perilaku dan tata pergaulan sehari-hari sesuai dengan nilai-nilai syari’at Islam. Salah satu adat istiadat masyarakat yang dimaksud adalah Edet Sumang. Penelitian ini bertujuan untuk mengetahui sejarah lahirnya Edet Sumang serta pengaruh Edet Sumang dalam pemahaman masyarakat Linung Bulen II, Kecamatan Bintang, Kabupaten Aceh Tengah. Penelitian ini merupakan penelitian lapangan, dengan menggunakan metode penelitian deskriftif dan pendekatan kualitatif. Sumber data yang digunakan adalah data primer yang bersumber dari wawancara dengan para informan yang telah ditentukan, sementara data sekunder adalah kutipan-kutipan dari hasil penelitian yang dilakukan oleh para peneliti sebelumnya. Hasil penelitian menunjukan filosofi Edet Sumang berupa pesan yang mengatur dan mengukur aspek kehidupan masyarakat, aturan ini berguna untuk menuntun sikap, perilaku pada masyarakat itu sendiri. Edet Sumang sebagai pemeger (Pagar) dan pelindung dirinya dari hal yang dianggap gere pantas (tidak pantas). Usaha untuk mempertahankan Edet Sumang sangat penting karena Edet Sumang dapat memberikan pengaruh positif terhadap kehidupan masyarakat Linung Bulen II, Kecamatan Bintang, Kabupaten Aceh Tengah.
Analisis Sensitivitas Model Matematika Penyebaran Penyakit Tuberkulosis
Authors: Harianto J , Tuturop K L 
Published: June 2022

Model matematika dapat memberikan masukan bagi praktisi kesehatan masyarakat dalam mencegah penyebaran penyakit tuberkulosis. Namun, model matematika harus diparameterisasi dan divalidasi dengan hati-hati berdasarkan data epidemiologis dan entomologis. Penelitian ini bertujuan menganalisis indeks sensitivitas setiap parameter dalam model. Hal ini perlu dilakukan untuk menentukan kepentingan relatif dari parameter model terhadap penularan penyakit tuberkulosis. Model yang dibahas dalam penelitian ini berbasis SEIL (S untuk rentan, E untuk individu yang beresiko tinggi, I untuk infeksi dan L untuk individu beresiko rendah) yang melibatkan pertumbuhan logistik. Metode yang digunakan adalah literature review. Hasil penelitian ini menginformasikan bahwa parameter laju kontak dan daya tampung merupakan parameter yang paling dominan terhadap peningkatan penyebaran penyakit tuberkulosis. Di sisi lain, parameter laju pengobatan individu yang terinfeksi merupakan parameter yang paling dominan terhadap penurunan penyebaran penyakit tuberkulosis
Application of Negative Binomial Regression Analysis to Overcome the Overdispersion of Poisson Regression Model for Malnutrition Cases in Indonesia
Authors: Setyawan Yudi , Suryowati Kris , Octaviana Dita 
Published: June 2022

Indonesia is one of the developing countries that is struggling to eradicate the malnutrition problem. Malnutrition that occurs over a long period of time can have an impact on the deaths of sufferers and decrease human quality of life. This study aims to model the case of malnutrition that occurred in Indonesia Provinces during 2015 and get the main factors that cause the malnutrition problem. Variables studied consist of Malnutrition (Y), Vitamin A consumption (X1), Exclusive breastfeeding (X2), Immunization (X3), Water quality (X4), Healthcare center (X5), and Poverty level (X6). Based on the Kolmogorov-Smirnov test, the results of malnutrition data in Indonesia Province in 2015 do not follow Poisson distribution because of overdispersion. The presence of overdispersion cases in the Poisson regression model will have an impact on the inappropriateness of inferences. An alternative model that accommodates this case is the negative binomial regression model. By using this model, factors that are considered influencing malnutrition cases in Indonesia provinces in 2015 are Immunization (X3), Water quality (X4), and Poverty level (X6).
Dobór przestrzenny, religijny oraz narodowościowy małżeństw i tożsamość Kaszubów w kontekście choroby genetycznej
Authors: Kwaśniewska Anna 
Published: June 2022

Deficyt enzymu LCHAD to rzadka choroba genetyczna, relatywie częsta w populacji kaszubskiej. Celem moich badań było przyjrzenie się kwestii pochodzenia przestrzennego (geograficznego), wyznaniowego i narodowościowego małżeństw na Kaszubach od lat 70. XIX w. do drugiej połowy XX w. i stwierdzenie czy uprawnione jest twierdzenie części lekarzy iż przyczyną dużej częstotliwości występowania tej choroby wśród Kaszubów jest izolacja spowodowana starymi tradycjami osadniczymi, małym napływ osób z zewnątrz, zawieraniem małżeństw w obrębie własnej miejscowości i grupy etniczo-regionalnej. Zajęłam się także wpływem choroby, a zwłaszcza jej potocznego określenia „gen kaszubski” na to tożsamość i obraz Kaszubów. Pokazuję iż choroba ta, a zwłaszcza jej niemedyczne określenie stygmatyzuje Kaszubów, podważa dumę etniczną, może stanowić źródło piętna i zranionej tożsamości. Pokazuję też, iż skutki społeczne - kulturowe deficytu enzymu LCHAD dotyczą nie tylko osób nią dotkniętych, ale całej grupy etniczno-regionalnej.
Abstract
LCHAD enzyme deficiency is a rare genetic disease that is relatively common in the Kashubian population. My research aimed to examine the issue of spatial (geographical), religious and national origin in marriages in Kashubia from the second half o the 19th century to the beginning of the 21st century to determine whether it is justifiable for some doctors to claim that the high frequency of this disease among Kashubians is caused by isolation due to settlement traditions, a small influx of new populations, endogamy within one’s place of habitat as well as their ethnic-regional group. I also focused on the influence of the disease, especially its colloquial term “the Kashubian gene”, on the identity and image of Kashubians. I demonstrate that this disease, particularly its non-medical term, stigmatizes Kashubians, undermines their ethnic pride, and can be a source of stigma and a wounded identity.
Perbandingan Model Pembelajaran Kooperatif Think Pair Square (Tps) Dengan Student Team Achievment Divission (Stad) Untuk Meningkatkan Kemampuan Komunikasi Matematika Siswa Pada Pokok Bahasan Himpunan
Authors: Saraswati Dewi 
Published: June 2022

The comparison between cooperative learning Think Pair Square (TPS) and Student Team Achievement Divissions (STAD) for improving Mathematics communication ability of Junior High school.The main purpose of this study was (1) to know difference between student who received cooperative learning Think Pair Square (TPS) and Student Team Achievement Divissions (STAD) (2) how mathematic communication ability students who learned with cooperative learning Think Pair Square (TPS) and Student Team Achievement Divissions (STAD)? which cooperative learning Think Pair Square (TPS) and Student Team Achievement Divissions (STAD) better for improving mathematic communication ability. This research is a form of experimental studies pre-test and post-test control group design. Research subjects grade VII A who received cooperative learning Think Pair Square (TPS) and grade VII B who received Student Team Achievement Divissions (STAD).The data was collected using a test instrument of the mathematical communication ability, attitude scales, and observation sheet. The results obtained are: 1) there are diference between student who received cooperative learning Think Pair Square (TPS) and Student Team Achievement Divissions (STAD) (2) mathematical communication ability of student receiving TPS type of cooperative learning Think Pair Square (TPS) better than student who receiving Student Team Achievement Divissions (STAD).(3) improving mathematical communication ability of students receiving TPS type of cooperative learning better than student who receiving Student Team Achievement Divissions (STAD)