bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality)
Authors: Pilgram Lisa , Eberwein Lukas , Jensen Bjoern-Erik O. , Jakob Carolin E. M. , Koehler Felix C. , Hower Martin , Kielstein Jan T. , Stecher Melanie , Hohenstein Bernd , Prasser Fabian , Westhoff Timm , de Miranda Susana M. Nunes , Vehreschild Maria J. G. T. , Lanznaster Julia , Dolff Sebastian ,   the LEOSS study group, Lanznaster Julia , Jensen Bjoern-Erik , Hower Martin , Hohenstein Bernd , Westhoff Timm , Vehreschild Maria , Spinner Christoph , Ruethrich Maria Madeleine , Tometten Lukas , Borgmann Stefan , Jung Norma , Hertenstein Bernd , Degenhardt Christian , Voigt Ingo , Hanses Frank , Wille Kai , Dahl Juergen vom , Rothfuss Katja , Hellwig Kerstin , Rupp Jan , Isberner Nora , Eberwein Lukas , Nattermann Jacob , Strauss Richard , Dolff Sebastian , Göpel Siri , Vehreschild Jörg Janne , de Miranda Susana M. Nunes , Jakob Carolin E. M. , Stecher Melanie , Pilgram Lisa , Schulze Nick , Fuhrmann Sandra , Schons Max , Claßen Annika , Franke Bernd , Prasser Fabian 
Published: April 2022

Abstract
Purpose
Patients suffering from chronic kidney disease (CKD) are in general at high risk for severe coronavirus disease (COVID-19) but dialysis-dependency (CKD5D) is poorly understood. We aimed to describe CKD5D patients in the different intervals of the pandemic and to evaluate pre-existing dialysis dependency as a potential risk factor for mortality.

Methods
In this multicentre cohort study, data from German study sites of the Lean European Open Survey on SARS-CoV-2-infected patients (LEOSS) were used. We multiply imputed missing data, performed subsequent analyses in each of the imputed data sets and pooled the results. Cases (CKD5D) and controls (CKD not requiring dialysis) were matched 1:1 by propensity-scoring. Effects on fatal outcome were calculated by multivariable logistic regression.

Results
The cohort consisted of 207 patients suffering from CKD5D and 964 potential controls. Multivariable regression of the whole cohort identified age (> 85 years adjusted odds ratio (aOR) 7.34, 95% CI 2.45–21.99), chronic heart failure (aOR 1.67, 95% CI 1.25–2.23), coronary artery disease (aOR 1.41, 95% CI 1.05–1.89) and active oncological disease (aOR 1.73, 95% CI 1.07–2.80) as risk factors for fatal outcome. Dialysis-dependency was not associated with a fatal outcome—neither in this analysis (aOR 1.08, 95% CI 0.75–1.54) nor in the conditional multivariable regression after matching (aOR 1.34, 95% CI 0.70–2.59).

Conclusions
In the present multicentre German cohort, dialysis dependency is not linked to fatal outcome in SARS-CoV-2-infected CKD patients. However, the mortality rate of 26% demonstrates that CKD patients are an extreme vulnerable population, irrespective of pre-existing dialysis-dependency.
Laser welding of 16MnCr5 butt welds with gap: resulting weld quality and fatigue strength assessment
Authors: Hensel J. , Köhler M. , Uhlenberg L. , Castro J. Diniz e , Dilger K. , Faß M. , Baumgartner J. 
Published: April 2022

AbstractFor laser welding, gaps should normally be avoided to ensure stable weld processes and high weld quality. Nonetheless, sometimes, gaps are resulting from non-optimal weld preparation in industrial applications. Within this investigation, the effects of a defocussed beam and laser beam oscillation on gap bridging abilities at reduced ambient pressure were investigated. For reference purpose, conventional laser welding with zero gap at ambient pressure was performed, too. The resulting weld geometry was investigated and correlated to gap bridging strategies and weld quality groups according to ISO 13919–1. The welds were characterized regarding their hardness and weld microstructure. Residual stress was determined by means of X-ray diffraction, and tensile tests as well as fatigue tests were conducted. The fatigue tests were evaluated by the nominal stress approach, the critical distance approach, and the stress averaging approach and correlated to weld quality measures. Resulting from this, fatigue resistance of laser welded butt welds with gap can be estimated by the FAT160 design S–N curve. The stress evaluation parameters for the determination ofkeff-values (ρ* = 0.4 mm,a = 0.1 mm) were confirmed.
Visibility Study in a Chief-Deputy Formation for CMB Polarization Missions
Authors: Bermejo-Ballesteros Juan , Cubas Javier , Casas Francisco , Martínez-González Enrique 
Published: April 2022

AbstractScientific instruments on board satellites are becoming increasingly sensitive, making it imperative to submit these instruments to a thorough calibration. In-flight calibration could be largely improved by using an ancillary microsatellite flying in formation with the main satellite and emitting a well-defined and known reference signal. Due to the main satellite attitude motion, the calibration satellite and therefore, its calibration signal, will only enter the instrument FoV (Field of View) at certain instants. It is not intuitive how frequently and during how much time this will happen, or how this depends on the scan strategy. In the present work, the available time for calibration and its characteristics in terms of total, mean, and maximum duration are studied, deriving analytical expressions for these quantities. These expressions are validated numerically and allow us to assess the impact of different scan strategies and to evaluate the most suitable region to locate the calibration satellite. The focal plane of the instrument is also modelled to evaluate the calibration process at detector level, calculating the number of detectors viewed and the direction of the polarized signal that they received. For this last analysis, only numerical methods have been employed. The tools are finally used in a case study in order to show how they can be employed to test, evaluate, and optimize scanning strategies and relative positions. The tools presented in this work can be easily adapted to evaluate more generally the characteristics of the observation of each point in the sky for a given scan strategy and instrument FoV.
An improved artificial bee colony algorithm based on Bayesian estimation
Authors: Wang Chunfeng , Shang Pengpeng , Shen Peiping 
Published: April 2022

AbstractArtificial bee colony (ABC) algorithm was proposed by mimicking the cooperative foraging behaviors of bees. As a member of swarm intelligence algorithms, ABC has some advantages in handling optimization problems. However, it has the exploration capacity over the exploitation capacity, which may lead to slow convergence speed and lower solution accuracy. Hence, to enhance the performance of the algorithm, a novel ABC based on Bayesian estimation (BEABC) is presented in this paper. First, instead of using the fitness ratio, the selection probability in ABC is replaced with a new probability calculated by Bayesian estimation. Second, to help the bees adopt more useful information during updating new food sources, a directional guidance mechanism is designed for onlooker bees and scout bees. Finally, the comprehensive performance of BEABC is evaluated by 24 single-objective test functions. The numerical experiment results indicate that BEABC dominates its peers over most test functions, and the significant statistics show that the significant excellence rate of BEABC is $$76\%$$

76
%

in the overall comparison. In addition, to further test the performance of BEABC, seven multi-objective problems and two real-word optimization problems are solved. The comparison results show that BEABC can achieve better results than other EA competitors.
Automatic data volley: game data acquisition with temporal-spatial filters
Authors: Cheng Xina , Liang Linzi , Ikenaga Takeshi 
Published: April 2022

AbstractData Volley is one of the most widely used sports analysis software for professional volleyball statistics analysis. To develop the automatic data volley system, the vision-based game data acquisition is a key technology, which includes the 3D multiple objects tracking, event detection and quality evaluation. This paper combines temporal and spatial features of the game information to achieve the game data acquisition. First, the time-vary fission filter is proposed to generate the prior state distribution for tracker initialization. By using the temporal continuity of image features, the variance of team state distribution can be approximated so that the initial state of each player can be filtered out. Second, the team formation mapping with sequential motion feature is proposed to deal with the detection of event type, which represents the players’ distribution from the spatial concept and the temporal relationship. At last, to estimate the quality, the relative spatial filters are proposed by extracting and describing additional features of the subsequent condition in different situations. Experiments are conducted on game videos from the Semifinal and Final Game of 2014 Japan Inter High School Games of Mens Volleyball in Tokyo Metropolitan Gymnasium. The results show 94.1% rounds are successfully initialized, the event type detection result achieves the average accuracy of 98.72%, and the success rate of the events’ quality evaluation achieves 97.27% on average.
Modification of milk resulting in low potassium and minimal electrolyte changes with minimal changes in taste
Authors: Hara Kazuhiro 
Published: April 2022

AbstractThe objective of this research communication was to produce low potassium milk in which other electrolyte changes and changes in taste were minimized. To reduce potassium concentrations, several studies have reported batch methods of directly mixing milk or formula with sodium polystyrene sulfonate, which can exchange cations such as potassium for sodium. However, they also reported increases in sodium content, decreases in calcium and magnesium content, and changes in taste, because sodium polystyrene sulfonate exchanged other substances such as calcium and magnesium for sodium. In the present study, a method of dialyzing whole cow's milk using both sodium polystyrene sulfonate and a small amount of water through cellophane membranes was developed. A batch method for comparison was also performed. Each milk sample was evaluated biochemically and analyzed for taste and aroma in a sensory analysis. We showed that the potassium concentration in the dialyzed milk was reduced to 38% of that in unreacted milk. It was also shown that changes in sodium (increased) as well as calcium and magnesium (decreased) in the dialyzed milk were less than half of those in the batch method milk. Sensory analysis showed that minimal changes occurred in the taste of the dialyzed milk.
Idiopathic subglottic stenosis – a familial association and review of practice
Authors: Hintze J M , Fitzgerald C W , O'Riordan I , Keane E , Kinsella J , Timon C 
Published: April 2022

AbstractObjectiveIdiopathic subglottic stenosis describes subglottic stenosis where no inflammatory, traumatic, iatrogenic or other causative aetiology can be identified. The present study aimed to outline our institution's experience of patients diagnosed with idiopathic subglottic stenosis and describe a very rarely reported familial association.MethodsA retrospective review was conducted of prospectively maintained medical records from 2011 to 2020. Patient clinical, radiological and intra-operative data were reviewed to assess for defined endpoints.ResultsTen patients with idiopathic subglottic stenosis were identified in this series. One familial pairing was identified, with two sisters presenting with the condition. Successful treatment with carbon dioxide laser and dilatation was achieved in most cases.ConclusionIdiopathic subglottic stenosis represents a rare, clinically challenging pathology. Management with endoscopic laser and balloon dilatation is an effective treatment. This paper highlights a very rare familial association, and describes our experience in treating idiopathic subglottic stenosis.
Adherence of Helicobacter pylori to Opisthorchis viverrini gut epithelium and the tegument mediated via L-fucose binding adhesin
Authors: Thanaphongdecha Prissadee , Chamgramol Yaovalux , Pairojkul Chawalit , Deenonpoe Raksawan , Suttiprapa Sutas , Brindley Paul J. , Sripa Banchob 
Published: April 2022

AbstractRecent reports implicate both the liver fluke Opisthorchis viverrini as a reservoir of Helicobacter pylori within the human gastrointestinal tract and H. pylori in the pathogenesis of opisthorchiasis-associated cholangiocarcinoma. We postulated that adherence of bacterial ligands to host receptors initiates colonization of the live fluke by H. pylori and here we aimed to assess the molecular interaction between O. viverrini and H. pylori by investigating host receptors for H. pylori in the fluke. Several known receptors of H. pylori including Lewis B, sialyl-Lewis X, Toll-like receptor 4 and L-fucose were detected immunohistochemically and histochemically by focusing analysis on the gut epithelium and tegument of the adult stage of the fluke. The frequency of detection of Lewis B, sialyl-Lewis X, TLR4 and L-fucose in 100 individual worms was 3, 3, 19 and 70%, respectively. Detection of H. pylori by a diagnostic ureA gene-based PCR assay revealed the presence of H. pylori in individual O. viverrini worms in 41 of 49 (79%) worms examined. In addition, numbers of bacteria decreased in a dose- and time-dependent fashion following exposure to fucosidase. These findings suggested that L-fucose represents a tractable receptor for H. pylori that can mediate bacterial colonization of the gut of O. viverrini.
Distribution of tree parameters by martingale approach
Authors: Isaev Mikhail , Southwell Angus , Zhukovskii Maksim 
Published: April 2022

AbstractFor a uniform random labelled tree, we find the limiting distribution of tree parameters which are stable (in some sense) with respect to local perturbations of the tree structure. The proof is based on the martingale central limit theorem and the Aldous–Broder algorithm. In particular, our general result implies the asymptotic normality of the number of occurrences of any given small pattern and the asymptotic log-normality of the number of automorphisms.
Divided left atrium with totally anomalous drainage of normally connected pulmonary veins
Authors: Anderson Robert H. , Jacobs Jeffrey P. , Franklin Rodney C.G. 
Published: April 2022

AbstractIn the December 2021 issue of Cardiology in the Young, Hubrechts and colleagues, from Brussels and Leuven in Belgium, describe their experience in which the pulmonary veins were normally connected to the morphologically left atrium. By virtue of the presence of a shelf dividing the morphologically left atrium, however, the venous return was to the morphologically right atrium, with no evidence of formation of the superior interatrial fold, meaning that there was no obstruction of flow into the systemic venous circulation. The question posed by the Belgian authors is whether the shelf dividing the morphologically left atrium is a deviated primary atrial septum, as the arrangement has previously been interpreted. As they discuss, it is currently impossible to arbitrate this conundrum. In our commentary, we discuss the background to the dilemma. We point out that, as yet, it is not possible to code accurately this congenital cardiac malformation within The International Paediatric and Congenital Cardiac Code (IPCCC), nor within the newly produced 11th Revision of the International Classification of Diseases (ICD-11).
Do smallholder farmers prefer commitment or flexibility in pension savings accounts? A randomised experiment of cocoa farmers in Ghana
Authors: Kos Diana , Lensink Robert 
Published: April 2022

AbstractThis paper examines the intertemporal choice preference for long-term savings of cocoa farmers in Ghana. We test the uptake of two pension products: with one, famers are free to withdraw 50% of their savings with no penalties prior to retirement age; with the other, only 30%. Using a randomised controlled trial we test the difference in uptake of two pensions products where we vary the flexibility of cash withdrawals from the pension account. We find an overall higher uptake of the more flexible pensions account, especially for women, who cannot inherit land titles in Ghana.
Racial Attitudes and Political Preferences Among Black and White Evangelicals
Authors: Allen Levi G. , Olson Shayla F. 
Published: April 2022

AbstractHow do racial group attitudes shape the political preferences of Black and white evangelicals? Scholarship has documented the relationship between religion and race in shaping political behavior and attitudes. However, less is known about how in-group and out-group racial attitudes operate within religious populations. Using samples of Black and white evangelicals from the 2012 and 2016 American National Election Studies, we explore the role of racial identity centrality and racial resentment in determining evangelicals' political preferences. While the role of Black and white identity among evangelicals is minimal, we find strong and consistent conservatizing effects for racial resentment. Together these findings suggest that the evangelical racial divide is not driven by Black evangelicals' attachment to their racial identity, but that racial resentment may drive white evangelicals to more conservative political preferences.
The Influence of State Favoritism on Established Religions and Their Competitors
Authors: Koev Dan 
Published: April 2022

AbstractWhat are the consequences of state support for, and official recognition of, one religion or religious institution over all others in the state? Previous studies have focused on the impact of a state's religion policies on overall religiosity in that state. In contrast, I argue that state support will have markedly different consequences for (1) the favored religious firm and (2) all other religious institutions. Similar to religious market theory, I expect that dependence on state support creates disincentives for the favored religious organization to attract adherents. However, I theorize that the weaknesses that state-backed favoritism engenders in the favored religion should create opportunities for other religious firms to compete and thrive. I conduct a multivariate quantitative analysis of changes in religious affiliation in 174 states between 1990 and 2010, controlling for factors like existential security, regime type, net migration, post-Communist background, and major religious traditions. My findings suggest that, consistent with my expectations, religious institutions that receive favorable treatment from the state lose ground relative to those that do not.
Pico-washing: simultaneous liquid addition and removal for continuous-flow washing of microdroplets
Authors: Siedlik Michael J. , Issadore David 
Published: April 2022

AbstractDroplet microfluidics is based on a toolbox of several established unit operations, including droplet generation, incubation, mixing, pico-injection, and sorting. In the last two decades, the development of droplet microfluidic systems, which incorporate these multiple unit operations into a workflow, has demonstrated unique capabilities in fields ranging from single-cell transcriptomic analyses to materials optimization. One unit operation that is sorely underdeveloped in droplet microfluidics is washing, exchange of the fluid in a droplet with a different fluid. Here, we demonstrate what we name the “pico-washer,” a unit operation capable of simultaneously adding fluid to and removing fluid from droplets in flow while requiring only a small footprint on a microfluidic chip. We describe the fabrication strategy, device architecture, and process parameters required for stable operation of this technology, which is capable of operating with kHz droplet throughput. Furthermore, we provide an image processing workflow to characterize the washing process with microsecond and micrometer resolution. Finally, we demonstrate the potential for integrated droplet workflows by arranging two of these unit operations in series with a droplet generator, describe a design rule for stable operation of the pico-washer when integrated into a system, and validate this design rule experimentally. We anticipate that this technology will contribute to continued development of the droplet microfluidics toolbox and the realization of novel droplet-based, multistep biological and chemical assays.
Effects of pharmacological treatment on metabolomic alterations in animal models of depression
Authors: Pu Juncai , Liu Yiyun , Gui Siwen , Tian Lu , Yu Yue , Wang Dongfang , Zhong Xiaogang , Chen Weiyi , Chen Xiaopeng , Chen Yue , Chen Xiang , Gong Xue , Liu Lanxiang , Li Wenxia , Wang Haiyang , Xie Peng 
Published: April 2022

AbstractNumerous studies have investigated metabolite alterations resulting from pharmacological treatment in depression models although few quantitative studies explored metabolites exhibiting constant alterations. This study aimed to identify consistently dysregulated metabolites across such studies using a knowledgebase-driven approach. This study was based on 157 studies that identified an assembly of 2757 differential metabolites in the brain, blood, urine, liver, and feces samples of depression models with pharmacological medication. The use of a vote-counting approach to identify consistently upregulated and downregulated metabolites showed that serotonin, dopamine, norepinephrine, gamma-aminobutyric acid, anandamide, tryptophan, hypoxanthine, and 3-methoxytyramine were upregulated in the brain, while quinolinic acid, glutamic acid, 5-hydroxyindoleacetic acid, myo-inositol, lactic acid, and the kynurenine/tryptophan ratio were downregulated. Circulating levels of trimethylamine N-oxide, isoleucine, leucine, tryptophan, creatine, serotonin, valine, betaine, and low-density lipoprotein were elevated. In contrast, levels of alpha-d-glucose, lactic acid, N-acetyl glycoprotein, glutamine, beta-d-glucose, corticosterone, alanine, phenylacetylglycine, glycine, high-density lipoprotein, arachidonic acid, myo-inositol, allantoin, and taurine were decreased. Moreover, 12 metabolites in urine and nine metabolites in the liver were dysregulated after treatment. Pharmacological treatment also increased fecal levels of butyric acid, acetic acid, propionic acid, and isovaleric acid. Collectively, metabolite disturbances induced by depression were reversed by pharmacological treatment. Pharmacological medication reversed the reduction of brain neurotransmitters caused by depression, modulated disturbance of the tryptophan-kynurenine pathway and inflammatory activation, and alleviated abnormalities of amino acid metabolism, energy metabolism, lipid metabolism, and gut microbiota-derived metabolites.
Trends and associated factors for Covid-19 hospitalisation and fatality risk in 2.3 million adults in England
Authors: Beaney T. , Neves A. L. , Alboksmaty A. , Ashrafian H. , Flott K. , Fowler A. , Benger J. R. , Aylin P. , Elkin S. , Darzi A. , Clarke J. 
Published: April 2022

AbstractThe Covid-19 mortality rate varies between countries and over time but the extent to which this is explained by the underlying risk in those infected is unclear. Using data on all adults in England with a positive Covid-19 test between 1st October 2020 and 30th April 2021 linked to clinical records, we examined trends and risk factors for hospital admission and mortality. Of 2,311,282 people included in the study, 164,046 (7.1%) were admitted and 53,156 (2.3%) died within 28 days of a positive Covid-19 test. We found significant variation in the case hospitalisation and mortality risk over time, which remained after accounting for the underlying risk of those infected. Older age groups, males, those resident in areas of greater socioeconomic deprivation, and those with obesity had higher odds of admission and death. People with severe mental illness and learning disability had the highest odds of admission and death. Our findings highlight both the role of external factors in Covid-19 admission and mortality risk and the need for more proactive care in the most vulnerable groups.