bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Field Investigations of Bypass Plunger Lift
Authors: Sayman Ozan , Tang Yula , Chow Jason , Farrell Kendall , Pereyra Eduardo , Sarica Cem 
Published: September 2022

Abstract
The fall and upstroke characteristics of bypass plunger are investigated for conventional and continuous flow plunger lift operations using experimental and field data. The bypass plunger's operational boundaries are compared with those of two-piece plungers. Clutch failure is also evaluated.
Bypass and two-piece plungers were tested in static and dynamic conditions to compare their fall drag characteristics with two different tubing and plunger sizes. Casing pressure buildup was used to surface the bypass plunger to represent the conventional plunger lift type of operation for the upstroke tests. Continuous gas and liquid injection were used to achieve multiphase flow conditions for bypass plunger experiments. Experimental findings retrieved from the study were combined with mechanistic models to predict fall and upstroke stages of the bypass plunger in the field conditions. Multiphase flow simulator results were presented, and its effect on plunger lift mechanistic models were discussed.
In the static facility, bypass plungers were found to have a higher drag coefficient, falling slower than sleeves of the same height. The drag coefficient values for 1.9-in OD and 2.34-in OD bypass and sleeves were similar, suggesting that plungers tested for a given tubing size can be extrapolated to others. The bypass plunger was suitable for conventional and continuous flow plunger lift operations. The 19.5-in bypass plunger and 9-in sleeve fall and upstroke velocities were analogous. Visual observations showed that the bypass plunger clutch mechanism may not get fully opened if the plunger does not hit the lubricator fast enough. The well test, high-frequency pressure, and plunger lift data of five wells from the Permian basin were analyzed. The continuous flow plunger-lift mechanistic models are used to estimate the bypass plunger cycle. The total cycle time and plunger run per day estimations matched with average run-time and trip-count field data.
The study presents the bypass plunger lift's cycle mechanics, operational limitations, and comparison with two-piece plungers in different tubing sizes. The experimental and field data of bypass plungers, mechanistic model benchmarking, and potential bypass plunger lift applications are featured.
Capillary Rise in Micro-Channels Accounting for Boundary Layer Effect and Wall Roughness for Shale Oil
Authors: Shen Anqi , Farouq Ali S. M. , Soliman M. Y. , Liu Yikun 
Published: September 2022

Abstract
A new capillary imbibition model is presented for shale that uses the momentum theorem of meniscus, for calculating the imbibition rate and height. Results are compared with those from previously published capillary rise models and also obtained in this research.
The new capillary rise model considers two main micro-level effects, viz. wall roughness and boundary layer. The imbibed fluid is divided into two parts in the calculation. One is the fluid close to the wall, affected by the wall roughness. The resistance of wall roughness is treated analogously to flow in porous media. The other part is the bulk fluid with a boundary layer. Also considered is the effect of pressure on the boundary layer during the imbibition process. The effects of wall roughness and boundary layer are discussed and compared.
An analytical expression for the evolution of the height of capillary rise in a single capillary and in a bundle capillaries is obtained as functions of time, considering both wall roughness and the boundary layer. It was found that the boundary layer enhances the nonlinear characteristic of imbibition, while it has a smaller influence on imbibition height, due to the relatively slow rate of imbibition at nano-scale. In nano-tubes, the wall roughness effect can be equivalent to that of a solid wall, which reduces the effective radius. Although the driving force of capillary rise is enhanced at nano-scale because of the small radius of capillary, the imbibition height does not increase compared to capillaries of larger radii at the same time, since these two microscale effects lower the capillary rise. However, for large times, the equilibrium height of capillary rise at nano-scale is higher than that in the larger radius capillary.
The novelty of the new model is used to understand capillary imbibition in porous media with nano-channels, which constitute the main mechanism for shale oil recovery after fracturing. It is believed that the proposed model will lead to improved shale oil production calculations.
Design and Implementation of Field Tests in Unconventional Reservoirs: Practical Perspectives
Authors: McClure Mark , Albrecht Maggie , Cipolla Craig , Molina Claudia 
Published: September 2022

Abstract
Optimizing the development of unconventional resources is a complex process, with significant uncertainty in reservoir characterization, completion effectiveness, and drainage efficiency. The primary parameters in the optimization are: stage length, cluster spacing, fluid type and volume, proppant type and loading, well spacing, landing zone(s), and lateral length. To improve over time, operators: evaluate alternatives, trial new designs, evaluate results, and iterate. This paper provides perspectives from industry practitioners on this process. It discusses: (a) defining objectives, (b) integrating information, (c) evaluating alternatives, (d) designing field trials, (e) evaluating outcomes, and (f) maximizing the value of field trials with diagnostic data collection.
Evaluation of Retrograde Condensate Dropout Phenomena in a Gas Condensate Reservoir
Authors: Hj Azlan Ali Al-Amani 
Published: September 2022

Abstract
The paper presents the result of an investigation of condensate drop-out phenomena through reservoir fluid characterization and well testing analysis to answer the condensate banking issue in an offshore gas field. Further evaluation via the Enhanced Gas Recovery (EGR) method has been conducted for condensate recovery optimization strategy.
The fluid characterization through EOS modelling is performed to match the laboratory results. Having achieved a reasonable match of the EOS model, the Condensate Gas Ratio (CGR) variation over pressure depletion is established and compared with the actual CGR profile to understand the severity of the condensate drop-out in the reservoir.
The investigation is continued in identifying the condensate banking behaviour. Multiple well testing data have been interpreted focusing on pressure derivative log-log plot matching, productivity index and skin factor changes. Interestingly, it is observed that the condensate banking issue is highly dependent on how the well completion and trajectory have been designed. A low deviated well has a higher tendency to experience severe condensate banking issues while the impact is reduced for a horizontal well.
Subsequently, a compositional model is built by converting from an existing black oil model. It is used in the investigation of the EGR strategy by injecting different types of gas at different timings and rates. Based on the simulation results, better condensate recovery factor is expected with the incremental between 4 to 8%.
The study can shed some light on the actual field experience and interesting lessons learned to be considered for a gas condensate reservoir development.
Defining Jacobian elliptic functions via nonpolynomial differential equations
Authors: Akande J. , Adjaï K. K. D. , Nonti M. , Monsia M. D. 
Published: September 2022

Abstract

Although Jacobi elliptic functions have been known for almost two centuries, they are still the subject of intensive investigation. In this paper, contrary to the usual definition, we prove that the Jacobi elliptic functions can be defined by using nonconservative equations with limit cycles through existence theorems involving first integrals. This allows extending their validity domains, that is, their range of applications.
What Are the Impacts of COVID-19 Pandemic on the Global Aquaculture Industry? The First Systematic Literature Review
Authors: Salajegheh Sina , Ardestani Mohammadreza Manouchehri , Fawzy Mohamed , Ghorbanzadeh Arman , Noor Mohd Iqbal Mohd , Saline Krishna R , Duarte Phelipe Magalhães 
Published: September 2022

Abstract
Global food demand is rising, and the recent threat of the COVID-19 pandemic has been predicted to adversely impact the prospects of aquaculture as one of the world's fastest-growing food sectors. There are presently no studies that comprehensively analyze the current research on the influence of COVID-19 on the global aquaculture business. This systematic review aimed to evaluate the current literature on the effect of the COVID-19 pandemic on the aquaculture industry. The present study integrated multiple research designs, and the Reporting Standards for Systematic Evidence Syntheses (ROSES) which was designed specifically for systematic literature review (SLR) and maps for the ecology and environment field. A total of 112 articles were located with the provided keywords using the ROSES methods. Only a total of 12 articles were considered for this SLR after title and abstract screening. Study’s quality was characterized as policy responses (n = 6), factors of production (n = 8), aquaculture animals’ welfare (n = 8), logistics (n = 9), demand and supply (n = 9), and prices (n = 9). This study has few limitations, including: (i) COVID-19 seems to be an ongoing global pandemic; thus, only a few years articles were available, (ii) only two most important databases were used, Scopus and Web of Sciences, without using grey literature, and (iii) this study only used articles that were published in the English. In conclusion, additional research is required to focus on the macro data (poverty and unemployment) and COVID-19 impacts on the environmental ecosystem without relying on survey perception. This research should also contain statistics of environmental impacts and hard data facts. Future policy proposals should be focused on the available technologies and should be based on the mitigation strategies for labour and lockdown issues of COVID-19. A systematic literature review thereby has a significant added value because this method is applicable to evaluate the available knowledge, current trends, and gaps regarding the impact of COVID-19 on the global aquaculture industry.
LncRNA GLTC targets LDHA for succinylation and enzyme activity to promote differentiated thyroid cancer progression and radioiodine resistance
Authors: Shi Liang , Duan Rui , Sun Zhenhua , Jia Qiong , Wu Wenyu , Wang Feng , Liu Jianjun , Zhang Hao , Xue Xue 
Published: September 2022

Abstract
Long noncoding RNA (lncRNA) dysregulation has been associated with the development and progression of many human cancers. Lactate dehydrogenase A (LDHA) enzyme activity is also crucial for cancer development, including that of differentiated thyroid cancer (DTC). Nevertheless, it remains unclear whether specific lncRNAs can regulate LDHA activity in cancer progression. Through screening, we identified an LDHA-interacting lncRNA, GLTC, which is required for increased aerobic glycolysis and cell proliferation in DTC. GLTC was significantly upregulated in DTC tissues compared with nontumorous thyroid tissues. High expression of GLTC was correlated with progressive histologic type, extent of distant metastases, larger tumor size, and poorer prognosis. Mass spectrometry revealed that GLTC, as a binding partner of LDHA, promotes the succinylation of LDHA on lysine-155 (K155) via its competitive inhibition of the interaction between SIRT5 and LDHA, thereby promoting LDHA enzymatic activity. Overexpression of the succinylation-mimic LDHAK155E mutant restored glycolytic metabolism and proliferation in cells that had ceased metabolic reprogramming and proliferation due to GLTC depletion. Interestingly, GLTC inhibition abrogated the effects of succinylated LDHA K155 on radioiodine (RAI) resistance in vitro and in vivo. Taken together, our results indicate that GLTC plays an oncogenic role and is an attractive RAI sensitization target for the treatment of DTC.
Immunophenotypic and Molecular Cytogenetic Associations of CD19 Expression in Acute Myeloid Leukemias, including in the t(8;21) negative setting
Authors: Bhavsar Shweta , Jain Sarika , Yatsenko Svetlana , Surti Urvashi , Swerdlow Steven , Aggarwal Nidhi 
Published: September 2022

Abstract
Aberrant CD19 expression is common in acute myeloid leukemia (AML) with t(8;21)(q22;q22.1). This study aims to investigate the incidence, clinical, immunophenotypic, molecular and cytogenetic associations of CD19 expression, especially in t(8;21) negative AMLs. We evaluated CD19 by flow cytometry (FC) in blasts of 739 consecutive non-promyelocytic AMLs. 52/739 AMLs (7%) expressed CD19 on at least a subset of blasts {range 1–90%, distinct subset (16/52), variable expression (36/52)}. 100/739 CD19 negative (-) cases with available NGS studies were selected as controls. The most common 2016 WHO AML subtypes in the CD19 + group were AML with t(8;21)(q22;q22.1);RUNX1::RUNX1T1, mutated NPM1, mutated RUNX1 and biallelic mutation of CEBPA. RUNX1 aberrations including t(8;21) (n = 19), RUNX1 mutations (n = 7), variant RUNX1 translocations (n = 3), RUNX1 deletion (n = 1) and RUNX1 amplification (n = 1), were the most common genetic abnormality in the CD19 + AML (31/52) and were statistically more common than in CD19- AML (11/100) (p = < 0.0001). CD19 was positive in all RUNX1 rearranged cases (n = 22) and 41% (7/17) of the AMLs with RUNX1 mutations. FLT3 mutations were also significantly more common in CD19 + AMLs (20/50, p = 0.001). 42% (14/33) of the CD19 + AMLs showed expression of at least one other B-cell marker by FC (CD22 and/or CD79a). TdT positivity was seen in 25/51 CD19 + AML, including all RUNX1 mutated cases. CD56 was expressed in 14/19 AMLs with t(8;21), but not in any AML with RUNX1 mutations (CD19 + and CD19- groups). 9/9 CD19 + NPM1 mutated AMLs were positive for CD7 compared to only 1/19 AMLs with t(8;21). In conclusion, we found that CD19 is expressed in at least a subset of blasts in ~ 7% of non-promyelocytic AMLs that are enriched in those with RUNX1 aberrations and FLT3 mutations. These cases also highlight that AMLs expressing CD19 can also express other B-cell antigens and must not be misdiagnosed as mixed phenotype acute leukemia.
Integrated metabolome and transcriptome reveals the mechanism of the flower coloration in cashew (Anacardium occidentale Linn.)
Authors: Zhang Zhongrun , Huang Weijian , Xiao Liyan , Huang Haijie 
Published: September 2022

Abstract

Background
Cashew is a widely attractive food in the world with high nutritional value for human health. The quality of cashew is closely associated with the flower coloration. However, the underlying mechanism of flower coloration of cashew was poorly understood. Here, we identified two cashew cultivars with variable flower coloration. Then, integrated analysis of metabolome and transcriptome was performed to explore the potential mechanisms.
Results
The results showed that 8 flavonoid compounds were markedly accumulated in red flower cashew, including taxifolin, procyanidin B2, delphinidin-3-O-glucoside, peonidin-3-glucoside, L-epicatechin, chalconaringenin, luteolin, naringenin and chrysin. In particular, delphinidin-3-O-glucoside, peonidin-3-glucoside and procyanidin B2 were key metabolites that promoted the formation of red flower coloration. Transcriptome analysis revealed that genes involved in flavonoid biosynthesis were also varied among these two cultivars. The flavonoid biosynthesis direction was reprogrammed to synthesize delphinidin-3-O-glucoside, peonidin-3-glucoside and procyanidin B2. Typically, four core genes encoding anthocyanin synthesis were also highly expressed in cashew with red flower, including CFI (TRINITY_DN4346_c0_g1), CHS2 (TRINITY_DN16129_c0_g1), CHS1 (TRINITY_DN2623_c0_g1) and F3H (TRINITY_DN8780_c0_g1).
Conclusions
This study sheds light on flavonoid metabolic pathways and candidate genes varied in two cashew cultivars and lays a foundation for the breeding programs of cashew.
Co-clustering of EphB6 and ephrinB1 in trans suppresses cancer cell invasion
Authors: Liang Lung-Yu , Geoghegan Niall , Mlodzianoski Michael , Leis Andrew , Whitehead Lachlan , Surudoi Minglyanna , Young Samuel , Janes Peter , Ghosal Debnath , Rogers Kelly , Murphy James , Lucet Isabelle 
Published: September 2022

Abstract
EphB6 is an understudied ephrin receptor tyrosine pseudokinase, the expression of which is downregulated in multiple types of metastatic cancers. Compared to its kinase-active counterparts, how EphB6 regulates signal transduction in the absence of intrinsic kinase activity remains unknown. Here, we unveil the molecular details of key signal transduction mechanisms driven by EphB6. We identify ephrinB1 as a cognate ligand of EphB6 and demonstrate EphB6’s ability to form extensive co-clusters at the plasma membrane upon binding ephrinB1 in trans across cell-cell contacts, which are resistant to endocytosis. Using super resolution microscopy, correlative light and electron microscopy and cryo-electron tomography, we reveal that co clustering of EphB6 and ephrinB1 promotes the formation of unprecedented double membrane tubular structure interconnecting cells. Importantly, phenotypically, co-clustering of EphB6 and ephrinB1 and the resulting tubular structures suppress cancer cell invasion by prolonging cell-cell contacts, rationalising a role for EphB6 pseudokinase as a tumor suppressor when interacting with its ligands in trans.
Prevalence and association of frailty with SARS-CoV-2 infection in older adults in Southern Switzerland—Findings from the Corona Immunitas Ticino Study
Authors: Jiang Miao , Corna Laurie , Amati Rebecca , Piumatti Giovanni , Franscella Giovanni , Crivelli Luca , Albanese Emiliano 
Published: September 2022

Abstract
Background
Frailty is an age-associated state of increased vulnerability to stressors that strongly predicts poor health outcomes. Epidemiological evidence on frailty is limited during the COVID-19 pandemic, and whether frailty is associated with the risk of infection is unknown.
Objectives
We derived a robust Frailty Index (FI) to measure the prevalence of frailty and its risk factors in community-dwelling older adults in Southern Switzerland (Ticino), and we explored the association between frailty and serologically confirmed SARS-CoV-2 infection.
Methods
In September 2020, we recruited a random sample of community-dwelling older adults (65+) in the Corona Immunitas Ticino prospective cohort study (CIT) and assessed a variety of lifestyle and health characteristics. We selected 30 health-related variables, computed the Rockwood FI, and applied standard thresholds for robust (FI < 0.1), pre-frail (0.1 ≤ FI < 0.21), and frail (FI ≥ 0.21).
Results
Complete data for the FI was available for 660 older adults. The FI score ranged between zero (no frailty) and 0.59. The prevalence of frailty and pre-frailty were 10.3% and 48.2% respectively. The log-transformed FI score increased by age similarly in males and females, on average by 2.8% (p < 0.001) per one-year increase in age. Out of 481 participants with a valid serological test, 11.2% were seropositive to either anti-SARS-CoV-2 IgA or IgG. The frailty status and seropositivity were not statistically associated (p = 0.236).
Conclusion
Advanced age increases the risk of frailty. The risk of COVID-19 infection in older adults may not differ by frailty status.
Are all ventilators for NIV performing the same? A bench analysis.
Authors: Castro Sara Martínez , Nacher Francisco Javier Belda , Bernabeu Jaume Puig , Domingo Marina Soro , Navarro Carlos Delgado , Pons Héctor Ortega 
Published: September 2022

Abstract

Background
Global pandemic due to COVID-19 has increased the interest for ventilators´ use worldwide. New devices have been developed and older ones have undergone a renewed interest, but we lack robust evidence about performance of each ventilator to match appropriate device to a given patient and care environment.
Methods
The aim of this bench study was to investigate the performance of six devices for noninvasive ventilation, and to compare them in terms of volume delivered, trigger response, pressurization capacity and synchronization in volume assisted controlled and pressure support ventilation. All ventilators were tested under thirty-six experimental conditions by using the lung model ASL5000® (IngMar Medical, Pittsburgh, PA). Two leaks levels, two muscle inspiratory efforts and three mechanical patterns were combined for simulation. Trigger function was assessed by measurement of trigger-delay time. Pressurization capacity was evaluated as area under the pressure-time curve over the first 500 ms after inspiratory effort onset. Synchronization was evaluated by the asynchrony index and by incidence and type of asynchronies in each condition.
Results
All ventilators showed a good performance, even if pressurization capacity was worse than expected. Leak level did not affect their function. Differences were found during low muscle effort and obstructive pattern. In general, Philips Trilogy Evo/EV300 and Hamilton C3 showed the best results.
Conclusions
NIV devices successfully compensate air leaks but still underperform with low muscle effort and obstructive lungs. Clinicians´ must have a clear understanding of the goals of NIV both for devices´ choice and set main parameters to achieve therapy success.
Influence of micropillar array structures on evaporation and wetting transition of fakir drops: Recipe for superhydrophobicity
Authors: Shamim Jubair A. , Takahashi Yukinari , Goswami Anjan , Shaukat Nadeem , Hsu Wei-Lun , Choi Junho , Daiguji Hirofumi 
Published: September 2022

Abstract

This study experimentally investigated the evaporation and wetting transition behavior of fakir drops on five different microstructured surfaces. Diamond-like carbon was introduced as the substrate, and the influence of varying the width, height, and pitch of the micropillars was assessed. The results showed that different evaporation modes emerged during the transition, which were influenced by the interfacial properties of the surfaces. In addition, the resistance of superhydrophobic surfaces to the Cassie–Baxter to Wenzel transition was strongly dependent on the depinning ability of the three-phase contact line of the liquid drop. The accuracy of the theoretical models for predicting the critical transition parameters was discussed, and a numerical model was developed in the surface evolver to compute the penetration of the drop bottom meniscus within the micropillars. Finally, a robust superhydrophobic surface capable of suppressing the Cassie–Baxter to Wenzel transition without a hierarchical nanostructure for microdroplets less than 0.37 mm in diameter was demonstrated as the key outcome of this study.