bluuebunny/crossref_metadata_2025_split huggingface dataset:
Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
Authors: Vogt Elinor Chelsom , Real Francisco Gómez , Husebye Eystein Sverre , Björnsdottir Sigridur , Benediktsdottir Bryndis , Bertelsen Randi Jacobsen , Demoly Pascal , Franklin Karl Anders , de Aja Gallastegui Leire Sainz , González Francisco Javier Callejas , Heinrich Joachim , Holm Mathias , Jogi Nils Oscar , Leynaert Benedicte , Lindberg Eva , Malinovschi Andrei , Martínez-Moratalla Jesús , Mayoral Raúl Godoy , Oudin Anna , Pereira-Vega Antonio , Semjen Chantal Raherison , Schlünssen Vivi , Triebner Kai , Øksnes Marianne 
Published: May 2022

Objective
To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women.

Design
Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women.

Methods
Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI.

Results
Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63–3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin.

Conclusion
Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.
SGA-born adults with postnatal catch-up have a persistently unfavourable metabolic health profile and increased adiposity at age 32 years
Authors: Goedegebuure Wesley Jim , Van der Steen Manouk , Smeets Carolina Catharina Johanna , Kerkhof Gerthe Femke , Hokken-Koelega Anita Charlotte Suzanne 
Published: May 2022

Abstract

Background
Catch-up in weight-for-length in the first year of life results in more insulin resistance, an adverse lipid profile and more fat mass (FM) in 21-year-old adults born small for gestational age (SGA-CU) compared to peers born SGA without catch-up and those born appropriate for gestational age (AGA). The aim of present study was to investigate if the adverse metabolic health profile in the SGA-CU group would worsen or remain stable over the years and to determine the cardiometabolic health at 32 years between the SGA and AGA groups.

Methods
We longitudinally investigated 287 adults, 170 SGA with catch-up growth (SGA-CU) or persistent short stature (SGA-S) and 117 AGA at ages 21 and 32 years. Insulin sensitivity (Si) and β-cell function were measured by frequently sampled i.v. glucose tolerance test, body composition by dual-energy X-ray absorptiometry (DXA) scan, and abdominal adipose tissue and liver fat fraction by MRI scan. Also, fasting serum lipid levels and blood pressure were measured.

Results
At age 32 years, SGA-CU had lower Si than AGA (P  = 0.030), while SGA-S had similar Si than AGA. FM and trunk fat were higher in SGA-CU than AGA (P  = 0.033, P  = 0.024, respectively), while SGA-S had lower lean body mass than SGA-CU and AGA (P  = 0.001 and P  &lt; 0.001, respectively). SGA-CU had significantly higher levels of adverse lipids than AGA. Beta-cell function, visceral fat, liver fat fraction and blood pressure were similar in all groups. Metabolic health parameters in SGA-CU and SGA-S did not worsen compared to AGA during 11 years of follow-up. Gain in weight SDS from birth to age 32 years was associated with a higher risk of developing metabolic syndrome at age 32 years.

Conclusion
At age 32 years, SGA-CU adults had insulin resistance, higher FM with central adiposity and an adverse lipid profile. Postnatal catch-up growth increases the cardiometabolic risk; therefore, accelerated gain in weight should be prevented in SGA-born children.
Single-cell RNA sequencing in silent corticotroph tumors confirms impaired POMC processing and provides new insights into their invasive behavior
Authors: Zhang Dongyun , Hugo Willy , Bergsneider Marvin , Wang Marilene B , Kim Won , Vinters Harry V , Heaney Anthony P 
Published: May 2022

Abstract

Objective
Provide insights into the defective POMC processing and invasive behavior in silent pituitary corticotroph tumors.

Design and methods
Single-cell RNAseq was used to compare the cellular makeup and transcriptome of silent and active corticotroph tumors.

Results
A series of transcripts related to hormone processing peptidases and genes involved in the structural organization of secretory vesicles were reduced in silent compared to active corticotroph tumors. Most relevant to their invasive behavior, silent corticotroph tumors exhibited several features of epithelial-to-mesenchymal transition, with increased expression of mesenchymal genes along with the loss of transcripts that regulate hormonal biogenesis and secretion. Silent corticotroph tumor vascular smooth muscle cell and pericyte stromal cell populations also exhibited plasticity in their mesenchymal features.

Conclusions
Our findings provide novel insights into the mechanisms of impaired POMC processing and invasion in silent corticotroph tumors and suggest that a common transcriptional reprogramming mechanism simultaneously impairs POMC processing and activates tumor invasion.
Thyroid function tests, incongruent internally and with thyroid status, both in a pregnant woman and in her newborn daughter
Authors: D’Aurizio Federica , Biasotto Alessia , Cipri Claudia , Grimaldi Franco , Zucco Jessica , Marzinotto Stefania , Curcio Francesco , Benvenga Salvatore 
Published: May 2022

Introduction
Thyroid function tests (TFT) are extensively used in daily clinical practice. Here, we described a case of incongruent TFT both in a pregnant woman and in her newborn.

Case presentation
A 32-year-old woman, diagnosed with autoimmune thyroiditis during her first pregnancy, was monitored during her second gestation. At week 5 + 2 days, thyroid-stimulating hormone (TSH) and free thyroxine (FT4) values (Dimension VISTA 1500, Siemens Healthineers) were within normal limits. At week 19 + 5 days, TSH remained normal while FT4 increased approximately by three-fold. FT4 inconsistency was with both TSH and the clinical status since she continued to be clinically euthyroid. On the same serum sample, thyroid autoantibodies were negative. At week 25 + 4 days, the patient complained of palpitations and dyspnea, with tachycardia. Even though TSH was normal, high levels of both FT4 and free triiodothyronine (FT3) were interpreted as evidence of thyroid overactivity and methimazole was started. TFT of the pregnant woman continued to be monitored throughout gestation. Postpartum FT4 and FT3 gradually returned to normal. TFT, performed on the daughter’s serum, 3 days after birth, showed the same inconsistency as her mother but without clinical signs of congenital hyperthyroidism. Based on the clinical and laboratory setting, the presence of circulating autoantibodies against T3 and T4 (THAb) was suspected and demonstrated by radioimmunoprecipitation.

Conclusion
Analytical interferences should be supposed when TFT do not fit with the clinical picture and despite their infrequency, THAb must also be considered. To our knowledge, this is the first case describing the passage of THAb to the newborn.
Diagnostic accuracy of ultrasonographic features in detecting thyroid cancer in the transition age: a meta-analysis
Authors: Cozzolino Alessia , Filardi Tiziana , Simonelli Ilaria , Grani Giorgio , Virili Camilla , Stramazzo Ilaria , Santaguida Maria Giulia , Locantore Pietro , Maurici Massimo , Gianfrilli Daniele , Isidori Andrea M , Durante Cosimo , Pozza Carlotta , _ _ 
Published: May 2022

Context
Significant uncertainty exists about the diagnostic accuracy of ultrasonographic (US) features used to predict the risk of thyroid cancer in the pediatric population. Moreover, there are no specific indications for thyroid nodule evaluation in patients during the transition age.

Objective
The meta-analysis aimed to address the following question: which thyroid nodule US features have the highest accuracy in predicting malignancy in the transition age.

Methods
We performed a meta-analysis of observational/cohort/diagnostic accuracy studies dealing with thyroid nodule sonography, reporting US features, and using histology as a reference standard for the diagnosis of malignancy and histology or cytology for the diagnosis of benignity in the transition age (mean/median age 12–21 years).

Results
The inclusion criteria were met by 14 studies, published between 2005 and 2020, including 1306 thyroid nodules (mean size 17.9 mm) from 1168 subjects. The frequency of thyroid cancer was 36.6%. The US features with the highest diagnostic odds ratio (DOR) for malignancy were the presence of suspicious lymph nodes (DOR: 56.0 (95% CI: 26.0–119.0)), a ‘taller than wide’ shape of the nodule (6.0 (95% CI: 2.0–16.0)), the presence of microcalcifications (13.0 (95% CI: 6.0–29.0)) and irregular margins (9.0 (95% CI: 5.0–17.0)). Heterogeneity among the studies was substantial.

Conclusions
Following the diagnosis of a thyroid nodule in the transition age, a thorough US examination of the neck is warranted. The detection of suspicious lymph nodes and/or thyroid nodules with a ‘taller than wide’ shape, microcalcifications, and irregular margins is associated with the highest risk of malignancy in the selection of nodules candidates for biopsy.
Insights into the decomposition of zirconium acetylacetonate using synchrotron radiation: Routes to the formation of volatile Zr-intermediates
Authors: Grimm Sebastian , Baik Seung-Jin , Hemberger Patrick , Kasper Tina , Kempf Andreas M. , Atakan Burak 
Published: May 2022

AbstractThe thermal decomposition of Zr(acac)4 is studied in a SiC-microreactor on the micro-second time scale. By utilizing synchrotron radiation and photoelectron photoion coincidence spectroscopy, six important zirconium intermediates, as for instance Zr(C5H7O2)2(C5H6O2), and Zr(C5H6O2)2, are identified in the gas phase for the first time. The adiabatic ionization thresholds of intermediately formed zirconium species are estimated and the main products of their thermal decomposition, acetylacetone, acetylallene and acetone are characterized unambiguously and isomer-selectively. Based on all detected intermediates, we deduce the predominant pyrolysis pathways of the precursor in the temperature range from 400 to 900 K. Our findings are complemented by numerical simulations of the flow field in the microreactor, which show that the choice of dilution gas significantly influences the temperature profile and residence times in the microreactor, such that helium provides a more uniform flow field than argon and should preferentially be used.
Graphical abstract
Using a soft ionization method coupled to velocity map imaging (VMI), leads to valuable insights in the thermal decomposition of Zr(C5H7O2)4, used in the synthesis of functional nanomaterials and ceramic coatings. Thanks to the use of a microreactor, important gas
WHAT IS EPIGENETIC CHANGE AND WHAT DO WE KNOW ABOUT ITS IMPACT ON MOLECULAR PATHOLOGIC MECHANISMS OF THE DISEASES?
Authors: BOZKURT Kemal Kürşat , TAN Ayca , ERTUNÇ Onur , ÖZTÜRK Rafet Güneş , ÇAKIR Yasemin , SAĞNAK YILMAZ Zeynep , ÜNLÜ Şadiye 
Published: May 2022

Epigenetic change refers to a phenotypic alteration
without permanent genotypic change, which occurs
through chromatin modification, DNA methylation,
histone modification, chromatin-regulating proteins
and non-coding RNAs. Post-transcriptional m6A
RNA methylation is also a newly described epigenetic
mechanism and believed to be a new diagnostic
biomarker and potential therapeutic target. It is a well-
known fact that epigenetic changes play a significant
role in the development and progression of several
nonneoplastic and neoplastic diseases. Therefore,
epigenetic changes are of value in diagnostic
and prognostic terms. On the other hand, with the
development of personalized medicine and targeted
treatment approaches, treatment strategies targeting
the epigenetic changes are becoming a promising
area for many diseases. The aim of this review is
to provide information about the mechanisms of
epigenetic changes and their role in the development
of neoplastic and nonneoplastic diseases, which may
be helpful for the clinicians and laboratory medicine
experts for further researchs.
Precarización laboral, desigualdad y nuevas tecnologías
Authors: Vergès Claude 
Published: May 2022

Propósito/Contexto. En este artículo se analiza el impacto de la inteligencia artificial para resolver las desigualdades existentes en América Latina.
Metodología/Enfoque. Se revisaron las estadísticas laborales y educativas oficiales de las Naciones Unidas y las aplicaciones de la inteligencia artificial en América Latina y El Caribe, y se analizaron desde la bioética y los derechos humanos.
Resultados/Hallazgos. La precariedad del empleo y el pobre acceso a la educación son permanentes en todos los informes. En este contexto, el reemplazo de las actividades por la inteligencia artificial presenta un riesgo alto a mediano para el empleo en el sector privado.
Discusión/Conclusiones/Contribuciones. El discurso predominante glorifica los beneficios de la tecnología, sin tomar en cuenta las desigualdades existentes. Sin embargo, este instrumento de transformación productiva debe ser evaluado analizando las relaciones de poder y su impacto social. La educación es una respuesta insuficiente mientras no se integra a las prioridades nacionales de desarrollo humano. La implementación de las diferentes formas de tecnología digital debe ofrecer alternativas reales de empleo pleno y seguro, cumpliendo con los artículos 14 y 16 de la Declaración Universal sobre Bioética y Derechos Humanos de 2005.
Development of entrepreneurial competence of future primary school teachers
Authors: Uaidullakyzy Elmira , Zhunusbekova Aziza , Roza Nabuova , Doszhan Raigul , Maratovna Karibayeva Gulnaz , Аbdigapbarova Ulzharkyn 
Published: May 2022

The aim of this study is to evaluate the opinions of prospective teachers regarding the development of entrepreneurial competencies of future primary school teachers. This research was designed in accordance with the qualitative research method. The research was conducted with 40 pre-service teachers who received primary school teacher training at various universities in Almaty, Kazakhstan. The data of the research were collected by interview technique in order to get the opinions of the teacher candidates participating in the research. As a result of the research, it has been seen that pre-service teachers associate their entrepreneurial skills with being innovative, evaluating opportunities, taking risks, self-confidence and emotional intelligence. In this direction, the majority of pre-service teachers stated that they partially have entrepreneurial skills. In addition, pre-service teachers stated that universities, schools, teachers and teacher candidates have duties to develop entrepreneurship skills. In line with the research results, it is necessary to intensify entrepreneurship courses for primary school teacher candidates in universities, and to organise seminars for personal development and development of entrepreneurship skills.

Keywords: Entrepreneurship, entrepreneurial skills, prospective teachers
Methodology of application of blended learning technology in mathematics education
Authors: Kadirbayeva Roza , Pardala Anthony , Alimkulova Baktygul , Adylbekova Elvira , Zhetpisbayeva Gulzhan , Jamankarayeva Madina 
Published: May 2022

The purpose of this research is to evaluate the application methodology of blended learning technology in mathematics education, with the views of teachers. In this study, the case study method, which is one of the qualitative research methods, was used. A total of 80 mathematics teachers working in various high schools in Nur Sultan city of Kazakhstan participated in the research. Research data were collected with a semi-structured interview form prepared by the researchers. As a result of the research, most of the mathematics teachers stated that the students' attitudes towards the mathematics lesson were negative. The majority of teachers participating in the research stated the combination of the superior features of face-to-face learning environments, diversity in learning and teaching methods, diversity in learning–teaching materials and increase in student success as the advantages of mathematics education in a blended learning environment. The majority of teachers participating in the research stated that the inadequacy of programmes suitable for blended learning, the deficiencies of software and hardware to be used in the course and the inability to use technology efficiently and effectively are the disadvantages of mathematics education in a blended learning environment. In-service training programmes should be organised to develop teachers' self-efficacy regarding blended learning environments and to ensure that they manage assessment and evaluation processes correctly.
Keywords: Psychological and pedagogical foundations, preschool teachers, teacher competencies
Psychological and pedagogical bases of research formation competence of preschool teachers in the context of lesson study
Authors: Myshbayeva Gulmira , Kyakbaeva Ulbosyn , Khairlayeva Gulsaya , Kamzaeva Kulshat , Baitas Nazgul 
Published: May 2022

The aim of this study is to evaluate preschool teachers' competencies in creating research on psychological and pedagogical foundations in the context of course work, with teacher views. The study group of the research consisted of 40 kindergarten teachers working in various schools in Almaty, Kazakhstan. In this study, the phenomenological approach, one of the qualitative research methods, was used. Research data were collected with a semi-structured interview form created by the researchers. As a result of the research, it has been determined that the self-efficacy and learning tendencies of preschool teachers are generally at a moderate level. In addition, preschool teachers, related to developing competences to research psychological and pedagogical foundations, expressed their opinions about participating in activities, following publications and participating in in-service trainings. In line with the results of the research, it has emerged that it is necessary to carry out studies to increase the self-efficacy and learning tendencies of preschool teachers.
Keywords: Psychological and pedagogical foundations, preschool teachers, teacher competencies
Prawo strony do czynnego udziału w postępowaniu dowodowym w sprawach dotyczących oszustwa w VAT
Authors: Konstańczak Magdalena 
Published: May 2022

Autorka polemizuje w artykule z poglądem sądów administracyjnych zakładającym, że art. 181 ustawy Ordynacja podatkowa nie przyjmuje zasady bezpośredniości postępowania dowodowego oraz że nie istnieje prawny nakaz, aby w postępowaniu podatkowym toczącym się równolegle do niezakończonego postępowania karnego albo karnego skarbowego konieczne było powtórzenie przesłuchania świadka, który zeznawał w ramach tych postępowań, albo powtórzenie przesłuchania oskarżonego, który w ich toku składał wyjaśnienia. Autorka stoi na stanowisku, że art. 181 ustawy Ordynacja podatkowa wyraźnie przewiduje powinność bezpośredniego utrwalania tych dowodów na etapie postępowania podatkowego. W artykule wskazano, że nieuzasadnione zaniechanie tej czynności arbitralną decyzją organu podatkowego godzi w prawo strony do rzetelnego procesu podatkowego, a decyzja oparta na takich dowodach zostaje wydana z naruszeniem prawa i powinna zostać wyeliminowana z obrotu prawnego w ramach jej sądowoadministracyjnej kontroli.
Rola mikrotargetingu w komunikacji marketingowej w polityce oraz innych branżach
Authors: Robaczyński Jakub 
Published: May 2022

Mikrotargeting to względnie nowe zjawisko stosowane w działalności marketingowej do segmentowania i personalizacji odbiorców. Aby można było scharakteryzować bardzo konkretne i efektywne grupy docelowe, potrzebne jest jednak wykorzystywanie dużych ilości danych online. System informatyczny przetwarza dane dotyczące zachowań użytkowników w sieci — identyfikuje cechy osobowościowe, behawioralne, społeczne i demograficzne. Takie dane pozwalają wyjątkowo dokładnie scharakteryzować odbiorcę w celu precyzyjnego zastosowania tych informacji w komunikacji.
Od pierwszych lat tego tysiąclecia technologia ta jest dość mocno implementowana do polityki. Pozwala to sztabom wyborczym na lepsze opracowanie strategii komunikacji z wyborcami w trakcie wyborów na dany urząd. Polityka cały czas się rozwija, a wybory na poszczególne urzędy są prowadzone w coraz to nowszy sposób. Powstaje tu pytanie, dlaczego to akurat mikrotargeting mierzy się z dużą niechęcią ze strony zwykłych obywateli? Okazuje się tymczasem, że nie ma on zastosowania tylko w polityce. Zidentyfikowano, że może być stosowany też w innych branżach, lecz dlaczego w tym kontekście się o nim nie mówi? Celem niniejszego artykułu jest identyfikacja mikrotargetingu jako formy komunikacji marketingowej oraz pokazanie możliwości zastosowania go w innych branżach. W pracy zastosowano przegląd literatury oraz wykonano badania wtórne na podstawie dostępnych raportów międzynarodowych.
Metabolic, kinematic and coordinative behavior of a para swimmer with cerebral palsy
Authors: De Jesus Kelly , Cardoso Larissa M. , De Jesus Karla 
Published: May 2022

BACKGROUND: It has been increasingly necessary to assess and monitor the physiological and biomechanics variables of para swimmers to enlarge the current knowledge on how different impairments limit swimming performance and explain each competition class variability in metabolic and technical terms.
AIM: To characterize the front crawl metabolic, kinematic, and coordination behaviors of a trained para swimmer subjected to an incremental protocol.
METHOD: A 44-year-old male, with moderate right side hemiparesis of the body, performed a 200-m front crawl at 5 incrementally paces until exhaustion (0.05 m/s increases and 30-s intervals), with images from two cycles at each step recorded by two video cameras (one surface and one underwater). Kinematic and coordinative variables were collected. Lactate concentrations, heart rate, and blood pressure were also measured.
RESULTS: The para swimmer achieved the anaerobic threshold at the fourth 200-m step, followed by an increase in heart rate and blood pressure. Speed and stroke frequency were higher and stroke length was lower along the 200-m steps. In contrast, a slight increase in stroke index and stability in intracyclic velocity variations occurred across intensity increments, and index of interlimb coordination was maintained as a superposition mode.
CONCLUSION: The findings suggest that the swimming intensity seems to influence the para swimmer metabolic, kinematic, and coordinative behavior, with sharper alterations after the point when AnT is achieved. In addition to having practical interest for adapted swimming, coaches should emphazise the physiological and biomechanical evaluation on training monitoring to better prescribe and improve the adapted swimming performance.