bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized controlled trials of acupuncture for the treatment of essential hypertension: a meta-analysis
Authors: Lu Yuqing , Li Lingjie , Wang Zhaoqin , Huang Yan , Zhong Rui , Xu Jing , Liu Huirong , Wu Huangan , Cheng Ling , Wu Luyi 
Published: November 2022

Abstract
Objective
To systematically assess the efficacy and safety of acupuncture therapy for essential hypertension.

Methods
A computerized literature search of the Chinese National Knowledge Infrastructure (CNKI), Chongqing VIP Database (CQVIP), Wanfang Academic Journal Full-text Database (Wanfang), China Biology Medicine Disc (CBM), PubMed, EMBASE, and Cochrane Library was conducted to retrieve randomized controlled clinical trials on acupuncture as the main intervention for the treatment of essential hypertension published from the inception of the database to 30 January 2021. The risk-of-bias assessment was carried out for each included study according to the Cochrane Handbook. Data analysis was performed using Review Manager 5.4.1 and Stata 15.0.

Results
After the screening, 46 randomized controlled trials involving a total of 3 859 subjects were included. Primary outcomes included changes in the diastolic blood pressure after intervention [eight studies showed that the acupuncture plus antihypertensive drug group was better than the antihypertensive drug monotherapy group [mean difference (MD)=1.45, 95% confidence interval (CI) (0.48, 2.43), P=0.004, fixed effects model; I2=39%] and changes in the systolic blood pressure after intervention {11 studies showed that the acupuncture plus antihypertensive drug group was better than the antihypertensive drug monotherapy group [MD=8.60, 95%CI (7.12, 10.07), P<0.00001, fixed effects model; I2=26%]}. The secondary outcome was antihypertensive efficacy, 12 studies of acupuncture monotherapy group [risk ratio (RR)=1.20, 95%CI (1.12, 1.28), P<0.00001, fixed effects model; I2=36%] and 15 studies of acupuncture combined with antihypertensive drug group [RR=1.27, 95%CI (1.20, 1.34), P<0.00001, fixed effects model; I2=6%] showed better results than the antihypertensive drug monotherapy group in antihypertensive efficacy. In terms of the adverse events, four studies showed that the acupuncture monotherapy group had fewer adverse events than the antihypertensive drug monotherapy group [RR=0.10, 95%CI (0.04, 0.25), P<0.00001, fixed effects model; I2=0%].

Conclusion
Acupuncture combined with antihypertensive drugs is superior to antihypertensive drugs alone in reducing blood pressure, and acupuncture therapy is effective and safe for the treatment of essential hypertension with fewer side effects. However, there is still a lack of high-quality multicenter randomized double-blinded controlled trials in this field. Rigorous large-sample clinical trials are needed to validate these findings.
Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
Authors: Lönnerblad Malin , Suominen Reina , Harila-Saari Arja 
Published: November 2022

Abstract
Purpose
This study aimed to explore educational outcomes in individuals diagnosed with lymphoma in childhood concerning school grade year 9 and attendance in high school and post-compulsory education. Whether sex or age at diagnosis affected the assessed variables was also explored.

Methods
Data from 174 children born 1988–1996 and diagnosed with lymphoma before age 15 were matched with approximately five controls per patient. The mean time since diagnosis to receiving school year 9 grades was 4.88 years for Hodgkin lymphoma (HL) cases (mean age at diagnosis 10.62, 11.76, and 10.05 years for all, girls, and boys, respectively) and 7.79 years for non-Hodgkin lymphoma (NHL) cases (mean age at diagnosis 7.85, 7.87, and 7.84 years for all, girls, and boys, respectively).

Results
We observed statistically significant differences between cases and controls in physical education, both for failing (p = 0.041) and the highest grade (p = 0.015). Compared with controls, HL cases were three times more likely to fail mathematics, and significantly fewer individuals in the whole lymphoma (p = 0.011) and NHL (p = 0.035) groups attended the third year of high school.

Conclusions
Educational outcomes are impacted for children treated for lymphoma, especially in physical education. Since patients with HL are treated without central nervous system-directed therapy, other factors, such as absence from school, may affect school results. Physical late complications in lymphoma survivors warrant special attention.

Implications for Cancer Survivors
The problems childhood lymphoma survivors face should be known by schools and parents, to enable their management. Children treated for lymphoma should be closely monitored and included in follow-up programs when needed, for example, to support physical activity.
Inappropriate proton pump inhibitor lansoprazole prescription in older adults hospitalized in long-term care unit
Authors: Ladjouzi Nadia , Romdhani Ahmed , Zouloumis Georges , Schlatter Joël 
Published: November 2022

Abstract

Purpose
We evaluated the use of the PPI treatment by physicians in older adults hospitalized in a long-term care unit.

Methods
We included 40 patients aged 65 years or older with a lansoprazole prescription hospitalized in long-term care unit from January 2018 to January 2022. Patient characteristics, gastroduodenal history, dose of lansoprazole, indication, days of prescription, and number of medications were collected from electronic patient records.

Results
The mean age of patients was 84.2 ± 9.3. Patients were taking between 5 and 24 (mean = 12.7, SD = 4.4) medications overall with 15 patients taking low dose of aspirin (75 mg daily) and 8 patients taking an antiplatelet. Most patients (82.5%) received once-daily lansoprazole treatment, 55% of whom took a dose of 15 mg. Five patients were treated with the maximum dose of lansoprazole 30 mg twice daily. Only seven patients had an appropriate indication. The minimum of treatment time was 3 days and the maximum was 1198 days; moreover, 24 patients (60%) were still in treatment.

Conclusion
Few PPI prescriptions had an indication in the patient’s electronic record. Prescriptions were ongoing with no date of discontinuation or re-evaluation.
Adolescent psychological well-being during the COVID-19 lockdown: the role of leisure activities and online peer communication
Authors: Norcia Anna Di , Mascaro Chiara , Bianchi Dora , Szpunar Giordana , Cannoni Eleonora 
Published: November 2022

AbstractThe present study investigated the effects of leisure activities and online peer relationships on the development of psychological difficulties in adolescents during the COVID-19 lockdown in Italy. Data were collected in April and May 2020. The parents of 1,020 Italian adolescents aged 14–18 (51.9% girls) completed questionnaires about the experiences and behaviors of their children before and during the lockdown. A moderation regression analysis was applied to test the research hypotheses. The findings indicated that adolescents who were more active in sports and social activities prior to the COVID-19 pandemic showed greater psychological distress during the lockdown. Moreover, increased reading, game playing, and exercise during the lockdown effectively compensated for the interruption of pre-pandemic sports and social activities, and represented a protective factor for adolescents’ mental health. Finally, increased online contact with peers during the lockdown protected against the development of psychological difficulties, regardless of adolescents’ engagement in sports and social activities prior to the pandemic. The findings provide new and useful information about the role of leisure activities and online contact with peers in protecting against psychological difficulties in adolescents, especially during situations of isolation and social distancing, as in the COVID-19 national lockdown.
The chronology of collective cheating: a qualitative study of collective dishonesty in academic contexts
Authors: Zanetti Cinzia , Butera Fabrizio 
Published: November 2022

AbstractCollective cheating can have serious consequences in professional and educational settings. Existing data show that collective cheating is common and that individuals cheat more when they are in groups, highlighting the existence of some collective organisation in the endeavour. However, little is known about the emergence of this behaviour and the group processing involved. Drawing on qualitative data from 20 semi-structured interviews and a thematic analysis, the present study explored collective cheating in academic contexts. Seven themes emerged that retrace the chronology of collective cheating from its beginning to its impact on the group: reasons, birth and organisation of collective cheating, risk management, concealment strategies, justifications and social impact. Participants emphasised the extrinsic benefits, the interdependence of members and the importance of existing social norms, as well as the positive valence of this kind of dishonesty. In participants' recalls, cheating together means cooperating, showing solidarity, helping and supporting each other.
Face masks drive increased rational decision-making
Authors: Fatfouta Ramzi , Oganian Yulia 
Published: November 2022

AbstractFace masks play a pivotal role in the control of respiratory diseases, such as the novel coronavirus (COVID-19). Despite their widespread use, little is known about how face masks affect human social interaction. Using unique experimental data collected early on in the pandemic, we investigate how facial occlusion by face masks alters socio-economic exchange. In a behavioral economics study (N = 481), individuals accepted more monetary offers and lower offer amounts when interacting with a masked versus unmasked opponent. Importantly, this effect was mainly driven by faces covered with surgical masks relative to bandana-type masks. In the first weeks of mask use during the COVID-19 pandemic, motive attributions further moderated this effect: Participants who believed that mask wearers were seeking to protect others showed the highest acceptance rates. Overall, we describe a new phenomenon, the face-mask effect on socio-economic exchange, and show that it is modulated by contextual factors.
Seasonal variability of hydrography off the east coast of Qatar, central Arabian Gulf
Authors: Al-Ansari Ebrahim M. A. S. , Husrevoglu Y. Sinan , Yigiterhan Oguz , Youssef Nabiha , Al-Maslamani Ibrahim A. , Abdel-Moati Mohamed A. , Al-Mohamedi Ahmad J. , Aboobacker Valliyil Mohammed , Vethamony Ponnumony 
Published: November 2022

AbstractSeasonal variability of hydrography along a nearshore-offshore transect in the eastern part of the EEZ of Qatar has been analyzed using in situ measurements carried out during 5 different months. The study reveals distinct features in temperature, salinity, density, dissolved oxygen (DO), and chlorophyll fluorescence. The sea surface temperature (SST) varies from nearshore to offshore with a positive gradient during January, June, and August, of the order of 1.0–2.0 °C, and with a negative gradient during October and April, of the order of 1.0 °C. Thermal stratification began in June, reached a well-defined thermocline with a vertical difference in temperature of about 10 °C during August, and started to de-stratify during October. The low salinity and low-density inflow of IOSW is evident in the surface layer of the middle of the transect during August, which has enriched the DO in the surface layer up to 20 m depth, while hypoxia prevailed below 50 m depth. The lowest chlorophyll fluorescence was measured in April 2013 (~ 1.0 μg l−1), moderate in June 2013 (~ 1.5 μg l−1), and relatively high in August 2013 (~ 6.0 μg l−1).
Flexibility within Quina lithic production systems and tool-use in Northern Italy: implications on Neanderthal behavior and ecology during early MIS 4
Authors: Delpiano Davide , Zupancich Andrea , Bertola Stefano , Martellotta Eva Francesca , Livraghi Alessandra , Cristiani Emanuela , Peresani Marco 
Published: November 2022

Abstract
The Quina Mousterian is one of the well-defined Middle Paleolithic techno-complexes. Despite the pivotal research carried out in south-western France, the presence of this techno-complex across the rest of Europe is still poorly documented. Here we apply a techno-functional approach, combining technological and use-wear analyses, for reconstructing lithic core-reduction, tool-reduction, and tool use at De Nadale Cave, a single-layered Mousterian site with Quina features located in northern Italy and dated to the early MIS 4. Our results indicate that the flexible core reduction strategies identified at De Nadale show some similarities with the Quina knapping method, in addition to the adoption of centripetal methods on single surfaces. Variations of this scheme identified at De Nadale are the exploitation of lateral and narrow fronts which are aimed to the production of elongated, small blanks. A parallel, ramified reduction is applied to limace cores and Quina or demi-Quina scrapers having diversified purpose (mixed matrix). These blanks are exploited as tools and cores-on-flakes from which thinner, usable flakes or bladelets are detached. The use-wear identified on both scrapers and reaffutage flakes further confirm this behavior, demonstrating the use of both tools, albeit for different tasks (i.e., scraping and cutting). We discuss the ecological implications of this behavior within the Quina Mousterian. The high frequency of retouched tools and Quina or demi-Quina scrapers seems to accompany the highly mobile human groups associated with this techno complex and their seasonally organized subsistence strategies. Finally, by combining available multidisciplinary data on paleoenvironment, subsistence, and chronology, we were able to embed the neanderthal settlement of De Nadale in a regional and Western European frame, underlining the importance of the Quina Mousterian in Western Eurasia between MIS 4 and early MIS 3.
Perspektiven von Schüler*innen auf Differenzkategorien im Sportunterricht
Authors: Bartsch Fabienne , Wagner Ingo , Rulofs Bettina 
Published: November 2022

ZusammenfassungDer Beitrag setzt sich mit der grundlegenden Frage auseinander, welche Differenzkategorien für die Teilhabe am Sportunterricht aus Schüler*innen-Perspektive besonders relevant sind. Dazu werden der Forschungsstand zu Inklusion und Heterogenität im Schulfach Sport beleuchtet, aus der Literatur Differenzkategorien deduziert und darauf aufbauend empirische Befunde aus einer Fragebogenerhebung mitN = 2546 Schüler*innen der Klassen sieben bis neun dargestellt. Im Fokus stehen dabei 23 aus der Literatur generierte Items, die sich auf Differenzkategorien beziehen und die von den Schüler*innen mittels einer fünfstufigen Skala hinsichtlich ihrer Bedeutung für den Sportunterricht bewertet wurden. Aus den mittels Clusteranalyse und Chi2-Tests ausgewerteten Daten lassen sich drei Schüler*innen-Cluster ermitteln, die sich in ihrer Wahrnehmung und Relevanzsetzung von Differenzkategorien im Sportunterricht unterscheiden. Zudem werden Unterschiede in der Clusterzusammensetzung erkennbar, die mit verschiedenen sozialstrukturellen Merkmalen der Schüler*innen (Alter/Klassenstufe, Geschlecht, Förderbedarf), den schulischen Rahmenbedingungen (Schulform, Schulklasse, Beschulungsform, Schulprogramm) und den Erfahrungen der Sportlehrkräfte (Teilnahme an Weiterbildungen) in Zusammenhang stehen. Die Befunde liefern Ansatzpunkte für die konkrete Umsetzung von Inklusion in der schulischen und sportunterrichtlichen Praxis (z. B. hinsichtlich der Ausrichtung des Schulprogramms, Teilnahme an Weiterbildungen) und für die weitere Forschung (z. B. hinsichtlich Schüler*innen mit Förderbedarf).
The new robotic platform Hugo™ RAS for lateral transabdominal adrenalectomy: a first world report of a series of five cases
Authors: Raffaelli Marco , Gallucci Pierpaolo , Voloudakis Nikolaos , Pennestrì Francesco , De Cicco Roberto , Arcuri Giovanni , De Crea Carmela , Bellantone Rocco 
Published: November 2022

AbstractRobotic assisted surgery is the most rapidly developing field of minimally invasive surgery. Its wide diffusion has led to the development and standardization of robotic-assisted approaches also for adrenalectomy. In this study, we present the first five robotic-assisted lateral transabdominal adrenalectomies performed with the new Hugo RAS™ system (Medtronic, Minneapolis, MN, USA). After an official training course of the surgical team, five consecutive patients scheduled for unilateral adrenalectomy, underwent robotic-assisted operations in our institution. Patients that were candidates for partial adrenalectomy were excluded. A description of the operating theatre, robotic arms and docking setup is provided. Four female and one male patient underwent lateral transabdominal adrenalectomy, three for lesions on the left side and two on the right. Median lesion size was 3.9 cm (range: 30–90) and preoperative diagnosis was Cushing’s syndrome in three patients, an adrenal cystic lesion and a pheochromocytoma. The median docking time was 5 min (range: 5–8) and the median console time was 55 min (range: 29–108). Procedures were performed without intraoperative complications and no conversions or additional ports were needed. System’s function and docking were uneventful. Based on our initial experience, adrenalectomy with the Hugo™ system is feasible. This study provides technical notes for other centres that wish to perform robotic-assisted adrenalectomies with the Hugo™ RAS as well as general information and our preliminary insights on this new platform.
Context vector-based visual mapless navigation in indoor using hierarchical semantic information and meta-learning
Authors: Li Fei , Guo Chi , Zhang Huyin , Luo Binhan 
Published: November 2022

AbstractVisual mapless navigation (VMN), modeling a direct mapping between sensory inputs and agent actions, aims to navigate from a stochastic origin location to a prescribed goal in an unseen scene. A fundamental yet challenging issue in visual mapless navigation is generalizing to a new scene. Furthermore, it is of pivotal concern to design a method to make effective policy learning. To address these issues, we introduce a novel visual mapless navigation model, which integrates hierarchical semantic information represented by context vector with meta-learning to improve the generalization performance gap between known and unknown environments. Extensive experimental results on AI2-THOR benchmark dataset demonstrate that our model significantly outperforms the state-of-the-art model by $$15.79\%$$

15.79
%

for the SPL and by $$23.83\%$$

23.83
%

for the success rate. In addition, the exploration rate experiment shows that our model can effectively improve the invalid exploration behavior of the agent and accelerate the convergence speed of the model. Our implementation code and data can be viewed on https://github.com/zhiyu-tech/WHU-CVVMN.
MXene-Based Composites as Nanozymes in Biomedicine: A Perspective
Authors: Iravani Siavash , Varma Rajender S. 
Published: November 2022

AbstractMXene-based nanozymes have garnered considerable attention because of their potential environmental and biomedical applications. These materials encompass alluring and manageable catalytic performances and physicochemical features, which make them suitable as (bio)sensors with high selectivity/sensitivity and efficiency. MXene-based structures with suitable electrical conductivity, biocompatibility, large surface area, optical/magnetic properties, and thermal/mechanical features can be applied in designing innovative nanozymes with area-dependent electrocatalytic performances. Despite the advances made, there is still a long way to deploy MXene-based nanozymes, especially in medical and healthcare applications; limitations pertaining the peroxidase-like activity and sensitivity/selectivity may restrict further practical applications of pristine MXenes. Thus, developing an efficient surface engineering tactic is still required to fabricate multifunctional MXene-based nanozymes with excellent activity. To obtain MXene-based nanozymes with unique physicochemical features and high stability, some crucial steps such as hybridization and modification ought to be performed. Notably, (nano)toxicological and long-term biosafety analyses along with clinical translation studies still need to be comprehensively addressed. Although very limited reports exist pertaining to the biomedical potentials of MXene-based nanozymes, the future explorations should transition toward the extensive research and detailed analyses to realize additional potentials of these structures in biomedicine with a focus on clinical and industrial aspects. In this perspective, therapeutic, diagnostic, and theranostic applications of MXene-based nanozymes are deliberated with a focus on future perspectives toward more successful clinical translational studies. The current state-of-the-art biomedical advances in the use of MXene-based nanozymes, as well as their developmental challenges and future prospects are also highlighted. In view of the fascinating properties of MXene-based nanozymes, these materials can open significant new opportunities in the future of bio- and nanomedicine.
Update zum Management der portalen Hypertonie nach Baveno VII – Was ist für die Praxis relevant?
Authors: Jachs Mathias , Mandorfer Mattias 
Published: November 2022

ZusammenfassungDer internationale Baveno-VII-Konsensus brachte zahlreiche wichtige Neuerungen zum Management der portalen Hypertonie mit sich. Die Schwerpunkte lagen auf der nichtinvasiven Diagnosestellung der klinisch signifikanten portalen Hypertonie, um eine frühzeitige Initiierung einer Carvediloltherapie zur Prävention der hepatischen Dekompensation zu ermöglichen. In diesem Kontext wurden auch Empfehlungen zur risikoadaptierten Behandlung von Patient*innen mit geheilter/supprimierter Grunderkrankung abgegeben, insbesondere zu jenen mit geheilter Hepatitis C. Darüber hinaus wurden auch die Empfehlungen hinsichtlich der Therapie der akuten Varizenblutung inklusive präemptiver Implantationen eines transjugulären intrahepatischen portosystemischen Shunts adaptiert. In diesem Artikel werden die wichtigsten Änderungen als Update für die Praxis zusammengefasst.