bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dubaï et le sport, image d’une société fracturée
Authors: Magoariec Raphaël Le 
Published: February 2022

L’émirat de Dubaï demeure l’une des premières principautés du Golfe à avoir investi la sphère du sport spectacle au cours de la décennie 1990. Témoin des changements de génération au sein du pouvoir dubaïote, l’intégration à ce domaine marque aussi l’entrée de l’émirat dans une nouvelle ère par une image nouvelle de « cité globale ». Étudier Dubaï à travers le prisme du sport permet de comprendre, d’une part, comment l’émirat investit le terrain sportif et quels sont ses objectifs affichés, d’autre part, comment le sport se vit et se pratique au sein de la société aux origines multiples évoluant dans l’émirat. Le sport permet ainsi de mettre au jour, non pas un, mais plusieurs visages de Dubaï qui se superposent les uns aux autres sans jamais réellement se côtoyer sur le terrain sportif.
TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells
Authors: Kawano Shotaro , Mitoma Hiroki , Inokuchi Shoichiro , Yamauchi Yusuke , Yokoyama Kana , Nogami Jumpei , Semba Yuichiro , Ayano Masahiro , Kimoto Yasutaka , Akahoshi Mitsuteru , Ono Nobuyuki , Arinobu Yojiro , Akashi Koichi , Horiuchi Takahiko , Niiro Hiroaki 
Published: February 2022

Abstract
T follicular regulatory (Tfr) cells are a subset of CD4+ T cells that express CXCR5 and migrate into germinal centers (GCs). They regulate GC reactions by communicating with T follicular helper (Tfh) and B cells. TNF inhibitors are used in inflammatory diseases; however, the generation of autoantibodies or anti-drug Abs sometimes causes problems. Because TNFR2 signaling is important for suppressive functions of regulatory T cells, we investigated the role of TNFR2 on human Tfr cells. Tfr cells stimulated with MR2-1 (an anti-TNFR2 agonistic Ab) were analyzed for cell proliferation, Foxp3 expression, and surface molecules. Tfh/B cell proliferation, IgM production, and differentiation in cocultures with MR2-1–stimulated Tfr cells were examined. Tfr cells express a high level of TNFR2. MR2-1 stimulation altered the gene expression profile of Tfr cells. Cell proliferation and Foxp3 expression of Tfr cells were enhanced by MR2-1. MR2-1–stimulated Tfr cells expressed ICOS and Programmed cell death protein 1 and significantly suppressed Tfh/B cell proliferation, IgM production, and B cell differentiation. TNFR2-stimulated Tfr cells retained the migration function according to the CXCL13 gradient. In conclusion, we showed that TNFR2-stiumulated Tfr cells can regulate Tfh and B cells. Aberrant antibody production during TNF inhibitor treatment might be, at least in part, associated with TNFR2 signaling inhibition in Tfr cells. In addition, expansion and maturation of Tfr cells via TNFR2 stimulation in vitro may be useful for a cell-based therapy in inflammatory and autoimmune diseases to control GC reactions.
Circulating T Cells Are Not Sufficient for Protective Immunity against Virulent Francisella tularensis
Authors: Roberts Lydia M , Wehrly Tara D , Leighton Ian , Hanley Patrick , Lovaglio Jamie , Smith Brian J , Bosio Catharine M 
Published: February 2022

Abstract
Pulmonary infections elicit a combination of tissue-resident and circulating T cell responses. Understanding the contribution of these anatomically distinct cellular pools in protective immune responses is critical for vaccine development. Francisella tularensis is a highly virulent bacterium capable of causing lethal systemic disease following pulmonary infection for which there is no currently licensed vaccine. Although T cells are required for survival of F. tularensis infection, the relative contribution of tissue-resident and circulating T cells is not completely understood, hampering design of effective, long-lasting vaccines directed against this bacterium. We have previously shown that resident T cells were not sufficient to protect against F. tularensis, suggesting circulating cells may serve a critical role in host defense. To elucidate the role of circulating T cells, we used a model of vaccination and challenge of parabiotic mice. Intranasally infected naive mice conjoined to immune animals had increased numbers of circulating memory T cells and similar splenic bacterial burdens as vaccinated–vaccinated pairs. However, bacterial loads in the lungs of naive parabionts were significantly greater than those observed in vaccinated–vaccinated pairs, but despite early control of F. tularensis replication, all naive–vaccinated pairs succumbed to infection. Together, these data define the specific roles of circulating and resident T cells in defense against infection that is initiated in the pulmonary compartment but ultimately causes disseminated disease. These data also provide evidence for employing vaccination strategies that elicit both pools of T cells for immunity against F. tularensis and may be a common theme for other disseminating bacterial infections.
Hypertension in Middle Eastern Arab and South Asian Patients with Atrial Fibrillation
Authors: Salam Amar M. , Salim Imtiaz , Kaddoura Rasha , Singh Rajvir , Asaad Nidal , Al-Qahtani Awad , Al Suwaidi Jassim , AlBinali Hajar A. 
Published: February 2022

Background:
The vast majority of literature on atrial fibrillation (AF) is based on studies from the developed world that mainly includes Caucasian patients. Data on AF in other ethnicities is very limited. The aim of this hospital-based study is to evaluate the effect of concomitant hypertension (HTN) on the characteristics and outcomes of Middle Eastern Arab and South Asian patients with AF in the state of Qatar.

Materials and Methods and Results:
During the 20-year period, 3850 AF patients were hospitalized; 1483 (38.5%) had HTN, and 2367 (61.5%) without HTN. Patients with HTN were 11 years older, compared to non-HTN patients, and had a significantly higher prevalence of diabetes mellitus, chronic kidney disease, and dyslipidemia, compared to non-HTN patients. Furthermore, underlying coronary artery disease and heart failure were significantly more common but not valvular and rheumatic heart diseases which were more common in those without HTN. The rates of in-hospital mortality and stroke were significantly higher in the presence of HTN (5.3% versus 3.5%, and 0.7% versus 0.2% respectively, P = 0.001), compared to non-HTN patients.

Conclusions:
HTN is significantly associated with more comorbidities and worse clinical outcomes when it coexists with AF in hospitalized Middle Eastern Arab and South Asian patients.
Knowledge, Attitude, and Practices Among Police Force Toward Covid-19 Pandemic During Lockdown in Pune, India - An Online Cross-Sectional Survey
Authors: Naresh Sonkawade D , Aarti Kinikar A , Kulkarni Rajesh , Valvi Chhaya , Rajput Uday C. , Dawre Rahul , Pawar Sameer , Jadhav Tushar , Chandanwale Ajay , Tambe Muralidhar , Venkatesham K. , Suryavanshi Nishi 
Published: February 2022

Background:
COVID-19 has affected millions of people and more than thirty thousand deaths. Social distancing and lockdown are important measures for prevention. Police personnel are losing their lives due to COVID-19 while doing their duty in this lockdown time.

Aim:
The study aims to assess knowledge, attitude, and practices (KAP) of police force toward COVID-19. To assess correlation of knowledge with their practices and attitude.

Materials and Methods:
A cross-sectional, self-administered, anonymous survey questionnaire was administered to 8706 police personnel and data collected over a time period from April 11 to 16, 2020. We used t-test and multivariable binary logistic regression analysis to identify the association between KAP and demographic variables.

Results:
In all 8706 police personnel participated in the study. The median age of participants was 35 years (interquartile range: 19–59), 6787 (77.9%) were male, 6675 (76.6%) were of constable grade. Seven thousand three hundred thirty-two (83.7%) of participants recorded accurate (high) knowledge, and 6790 (78%) reported following preventive practices. Female participants were more likely to follow preventive measures despite low knowledge as compared to their male counterparts (P < 0.0001). Female gender, age more than 35 years, and lower rank were associated with low knowledge and fear of contracting the disease. Multivariable binary logistic regression analysis showed that low knowledge is significantly associated with fear of getting disease odds ratio 1.29; 95% confidence interval (1.15–1.46).

Conclusion:
In a cohort of police personnel, overall knowledge about COVID-19 is high. Female participants are found to be practicing appropriate preventive measures and they have faced stigmatizing behavior from society. The study provides important information on the need for developing health awareness programs to improve COVID-19 KAP.
Role of Estrogen Receptor-α and Estrogen Receptor-β Expression in the Disease Outcome of Invasive Luminal Type a Breast Carcinoma Patients
Authors: Deshmukh Abhay Vilas , Gupta Anupama , Yadav Vandna , Mangam Shubhangi , Gangane Nitin M. 
Published: February 2022

Background:
Estrogen receptor (ER)-α and ERβ, members of family of ERs are expressed in many breast tumors. However, their role in carcinogenesis and their association with regard to the prognosis are still under the investigation and unclear because of limited data.

Aims:
The present cross-sectional, observational pilot study was aimed to study the immunohistochemical expression and prognostic significance of ERα and ERβ in invasive luminal Type A breast carcinoma patients.

Materials and Methods:
Twenty-five old diagnosed cases of luminal Type A breast carcinoma diagnosed between 2012 and 2015 were included in the study. The expression of markers ERα and ERβ was correlated with the clinical characteristics and disease outcome in 2–7 years' follow-up period. Statistical analysis was performed by SPSS version 17.0 and graph pad PRISM 5.0 version.

Results:
Eleven cases out of 25 were both (ERα and ERβ) positive, whereas 1 case was both (ERα and ERβ) negative. Positivity with single marker was 12 for ERα and 20 for ERβ. Adverse outcomes, i.e., recurrence, distant metastasis, and death were reported in 10 cases (40%), 8 out of which were ERα negative cases. While ERα-positive expression alone or along with ERβ expression was shown to be associated with less adverse outcomes (2 out of 10, P = 0.005).

Conclusions:
When both ERα and ERβ expression is present, they appear to act as allies and together presents with the better prognosis in disease outcomes of breast cancer in our study cases.
Study on Intestinal Helminthoses and the Efficacy of Anthelminthoses Drugs among School Children in Girei Local Government Area, Adamawa State
Authors: Osemeahon Patricia 
Published: February 2022

Intestinal helminthoses have adverse effects on the physical and mental development in poorly nourished community populations. This study was conducted to determine the prevalence of helminthoses and to evaluate the efficacy of two antihelminthoses drugs (albendazole and levamisole) among school aged pupils in Girei local government area of Adamawa State, Nigeria. A total of 384 primary school pupils were randomly selected from six public primary schools in Girei local government area of Adamawa state. Statistical tools used for data collection was a structured questionnaire, while simple percentages and chi-square test of association were used for data analysis with the help of statistical package for social sciences (SPSS) version 26. Clean plastic containers were distributed to the participants at enrollment with detailed instructions about the procedure for stool specimen collection. All stool samples were collected early in the morning and conserved in ice boxes before transportation to the laboratory. Each specimen was examined for the presence of intestinal parasitic organisms by the concentration techniques and kato-katz was used for egg count. The age specific prevalence were 21.1% among pupils with age 6-9 years, 17.1% among pupils with age ≥10 years and 10.4% among the youngest children ≤ 5years of age.
Keywords: Intestinal Helmnthosis, Efficacy; Anthelminthic; Drugs
Detection and Antibiogram of Bacteriological Contaminants in Commonly Consumed Sachet Water in Dutse, Jigawa State, Nigeria
Authors: Falnyi Ishaya , Yerima Mohammed , Mohammed Abdulkarim , Adeleye Adeniyi 
Published: February 2022

Potable water serves as an important source for primary prevention of diseases and the foundation for the prevention and control of water borne diseases. This study was conducted to determine the bacteriological quality of ten (10) brands of sachet water commonly consumed in Dutse urban, Jigawa state, Nigeria using Membrane Filtration Technique method for enumeration of both total coliform and fecal coliform counts. Eosin methylene blue, Salmonella Shigella and plate count media as well as membrane filters with 0.45µm pore size were used. Total bacterial counts for all the water samples were not within the recommended limits by regulatory bodies; Environmental Protection Agency, World Health Organization, and National Agency for Food and Drugs Administration and Control. Results revealed that the sampled sachet water was contaminated with Klebsiella aerogenes, Pseudomonas aeruginosa, Salmonella paratyphi A, Shigella flexneri, Proteus vulgaris, Proteus mirabilis and Streptococcus pyogenes. However, Ofloxacin and Ciprofloxacin revealed 100% potency against all the seven bacterial isolates while Augmentin have no effect (0%) on any of the bacterial isolates. Appropriate treatment processes should be utilized for the production of packaged water meant for human consumption. Again, drinking water regulatory bodies should be proactive in monitoring the adherence of drinking water manufacturers to regulated processing standards.
Keywords: Sachet water; bacterial isolates; total coliform; faecal coliform; membrane filtration technique
Antibacterial Activity, Phytochemical and Proximate Analysis of Moringa Oleifera Seeds Against Clinical Isolates
Authors: Umare Fatimah , Muhammad Mukhtar , Maiturare Hauwa , Abubakar Hauwa , Binji Zainab , Inuwa Fatima 
Published: February 2022

This study was carried out to determine the antibacterial activity, phytochemical and proximate analysis of Moringa oleifera seeds extracts against some clinical isolates. The antibacterial activity for Aqueous and Ethanol extracts was determined using the agar diffusion method. The Phytochemical Screening of the seed was carried out using Qualitative Analysis (QA) and proximate analysis was carried out according to AOAC methods. The aqueous seed extract showed varying degrees of antimicrobial activity over that of ethanol extract on the microorganisms tested. Two species (Staphylococcus aureus and Salmonella typhi) presented the lowest MIC of 31.25 and 125mg/ml compared to MBC of 250mg/ml respectively. The phytochemical revealed the presence of Flavonoids, Tannins, Alkaloid, and Saponins. The Proximate Analysis revealed high concentration of Crude lipid (35.58 ± 0.42%) and lowest concentration of Moisture content (2.03 ± 0.01%). This study shows that moringa oleifera seeds can be as effective as synthetic medicine to combat pathogenic microorganisms if properly utilized.
Keywords: Moringa oleifera seeds; Proximate analysis; Phytochemicals; Staphylococcus aureus
Initial experience with minimally invasive extracorporeal circulation in coronary artery bypass graft reoperations
Authors: Heinisch Paul Philipp  , Mihalj Maks , Haliguer Elif , Gahl Brigitta , Winkler Bernhard , Venetz Philipp , Jenni Hansjoerg , Schober Patrick , Erdoes Gabor , Luedi Markus M. , Schefold Joerg C. , Kadner Alexander , Huber Christoph , Carrel Thierry P. 
Published: February 2022

AIMS OF THE STUDY: Minimally invasive extracorporeal circulation (MiECC) is an established alternative to conventional extracorporeal circulation (CECC) in coronary artery bypass graft surgery (CABG), but data on its use in cardiac reoperations are limited. We aimed to analyse perioperative morbidity and mortality in adult patients undergoing reoperations for isolated CABG using either CECC or MiECC circuits at our centre.
METHODS AND RESULTS: In a single centre retrospective observational study of all adult patients undergoing cardiac reoperations for isolated CABG between 2004 and 2016, we identified 310 patients, and excluded those who received concomitant cardiac procedures (n = 205). Of the remaining 105 patients, 47 received isolated redo-CABG using MiECC, and 58 received CECC. Propensity score modelling was performed, and inversed probability treatment analysis was used between the treatment groups. Primary endpoint was 30-day all-cause mortality. Secondary endpoints included major adverse cardiac or cerebrovascular events or need for conversion to CECC. Groups were comparable, apart from a higher incidence of NYHA class III or higher in CECC group (33.5% vs 8.6%, p= 0.004). Shorter times for operation, cardiopulmonary bypass and aortic cross-clamp were observed in the MiECC group. The incidence of postoperative atrial fibrillation was significantly lower with MiECC (22.1%, p = 0.012). No significant difference was observed in all-cause 30-day mortality between the MiECC and CECC groups (6.8% vs. 8.3%, p = 0.81).
CONCLUSION: We found no difference in overall mortality between CECC and MiECC in patients undergoing reoperation for isolated CABG. Furthermore, we found no indication of differences in most outcomes between extracorporeal circuit types. In the case of redo-CABG, MiECC could provide an alternative strategy.
Qualitative analysis of healthcare providers and administrators' perceptions, expectations, barriers, and facilitators towards pharmacists in mental healthcare in Saudi Arabia
Authors: Aldhafeeri Badar Dhehawi A 
Published: February 2022

Objective: To explore the views and experiences of healthcare providers (HCPs) and their expectations toward pharmacists in mental healthcare, in addition to their acceptance of new pharmacist roles. Barriers and facilitators that are emerging in the process of developing enhanced pharmacist-related roles were also explored.
Methods: Qualitative semi-structured face-to-face interviews were conducted with HCPs who had worked in mental health services in Saudi Arabia. The data were thematically analysed using a constant comparison with NVivo software to develop a series of key themes from the interviews.
Results: Most HCPs indicated that they rarely interacted with pharmacists. They expected pharmacists to educate both patients and other healthcare workers in the future. Concerns were raised regarding inadequate pharmacy education and lack of clinical training for pharmacists.
Conclusion: This study revealed that interactions between HCPs and pharmacists concerning mental health are still limited. A communication strategy for addressing mental health issues should be developed among pharmacists and other HCPs.
IMPACTO DA QUALIDADE DE VIDA ATRAVÉS DOS PROCESSOS DE CULTURA ORGANIZACIONAL ALIADA A GESTÃO ESTRATÉGICA NO SETOR PÚBLICO
Authors: BORTOLO CARLOS ALEXANDRE DE , SANTOS LETÍCIA BARBOSA 
Published: February 2022

A junção das atividades ao bem-estar dos trabalhadores no que diz respeito à qualidade de vida no trabalho tem ganhado cada vez mais destaque. O objetivo geral do estudo foi analisar o impacto da qualidade de vida no trabalho através dos processos de cultura organizacional aliada a gestão estratégica no setor público em um órgão de ensino superior no município de Montes Claros. Os procedimentos metodológicos aplicados nesta pesquisa seguiram as delimitações propostas da pesquisa “As influências da cultura organizacional na prestação de serviços públicos”, assim trata-se de um estudo de natureza aplicada, exploratória e descritiva. Para a análise e identificação foi utilizado o Instrumento Brasileiro para Avaliação da Cultura Organizacional – IBACO adaptado à realidade do setor público, o questionário dispôs de 43 perguntas distribuídas em 06 fatores entre Valores e Práticas Organizacionais, foram utilizadas técnicas de estatística com escala Likert de cinco pontos paramensuração do grau da cultura organizacional. A amostra foi composta por 50 respondentes da área administrativa de uma instituição pública de ensino superior, obtendo 47 retornos. Após as análises dos dados em relação aos resultados do IBACO, pode-se entender a Cultura Organizacional moderada, que quer dizer que a instituição cumpre suas metas e atende as necessidades do usuário, no entanto seus colaboradores transitam por um ambiente cordial e diplomático, onde a qualidade de vida no trabalho é tida como baixa, o que foi descrito pela insatisfação dos servidores. Portanto, acerca da temática delimitada é possível contribuir com à instituição pesquisada demonstrando que as proposições afincadas podem ser reposicionadas, com a finalidade de propiciar um melhor bem-estar e produtividade; e viés preventivo em organizações públicas instaurar um plano dequalidade de vida no trabalho.
Palavras-chave: Qualidade de Vida no trabalho, Cultura Organizacional, Planejamento Estratégico e SetorPúblico.
Compliance with Antitrust Laws at the Stage of Elaboration of Strategy of Product Promotion (Theoretical and Practical Aspects)
Authors: Gorshkova E. A. , Barchuk N. D. 
Published: February 2022

The paper addresses the issues of necessity to consider antitrust restrictions at the stage of elaboration of strategy of product promotion. Potential damage arising from ignorance of legislation on protection of competition may negate the income received by using a marketing ploy, sequestering such income by way of turnover-based fine.The authors of the paper, while analyzing modern marketing ploys, by the example of “package” proposals of products give practical recommendations for antitrust risks management.The material herein is primarily intended for employees of commercial departments of economic entities, who are in charge of promotion and sales of products.
GOVERNMENT COMMUNICATION: A CRITICAL ANALYSIS OF THE STRATEGIC DIMENSIONS OF THE CENTRAL NATIONAL GOVERNMENT COMMUNICATION IN KENYA
Authors: Owino Ruth 
Published: February 2022

Purpose: The purpose of this study is to critically analyze the strategic dimensions of the central national government communication in Kenya. The structure of the central national government communication is comprised of Presidential Strategic Communication Unit (PSCU), Office of the Government Spokesperson (OGS), and Ministry of information communication technology (ICT).
Methodology: A single-case (embedded) research design was adopted and the target population was all the communication officers at the three government entities (PSCU, OGS, and Ministry of ICT). Data was collected through in-depth interviews and document analysis.
Findings: The study findings indicate that the structure and process of government communicators are decentralized, uncoordinated, and adhoc. Communication is partly strategic and partly political. The professionals are mainly either recruited through political appointments, recommendations or recruited from civil service. Further, government communication is characterized by the pursuit of short/medium-term goals; strong political influence; limited specialized communication units; positioned at the lower level of the government structure; and considered a tactical tool that performs media and publicity functions. The study’s findings are an important addition to the emerging field of government communication, especially on African scholarship where there is a serious dearth.
Unique contribution to theory, practice and policy: Given the environment under which government communication operates, the findings of this study contribute to the excellence theory of public relations that advocates for excellent communication units. The findings are also helpful to policymakers and researchers since it provides a better understanding of government communication for possible improvement, regulation, and replication.