bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases
Authors: Zhang Shi‐Zhao , Liang Peng‐Peng , Feng Ya‐Nan , Yin Guo‐Liang , Sun Feng‐Cui , Ma Chao‐Qun , Zhang Feng‐Xia 
Published: September 2022

AbstractDiosgenin, a steroidal saponin, is a natural product found in many plants. Diosgenin has a wide range of pharmacological activities, and has been used to treat cancer, nervous system diseases, inflammation, and infections. Numerous studies have shown that diosgenin has potential therapeutic value for lipid metabolism diseases via various pathways and mechanisms, such as controlling lipid synthesis, absorption, and inhibition of oxidative stress. These mechanisms and pathways have provided ideas for researchers to develop related drugs. In this review, we focus on data from animal and clinical studies, summarizing the toxicity of diosgenin, its pharmacological mechanism, recent research advances, and the related mechanisms of diosgenin as a drug for the treatment of lipid metabolism, especially in obesity, hyperlipidemia, nonalcoholic fatty liver disease, atherosclerosis, and diabetes. This systematic review will briefly describe the advantages of diosgenin as a potential therapeutic drug and seek to enhance our understanding of the pharmacological mechanism, recipe‐construction, and the development of novel therapeutics against lipid metabolism diseases.
Therapeutic potential of cranberry for kidney health and diseases
Authors: Amin Ruhul , Thalluri Chandrashekar , Docea Anca Oana , Sharifi‐Rad Javad , Calina Daniela 
Published: September 2022

AbstractA higher risk of cardiovascular mortality in persons with chronic renal failure (CRF) is linked to inflammation, oxidative stress, cellular aging, and gut dysbiosis, to name a few contributing factors. According to a growing body of evidence, some dietary choices may reduce the severity of certain adverse effects. Specialized databases such as PubMed/Medline, Embase, Google Scholar, and UpToDate were searched to find published studies that focus on the pharmacological effects and mechanisms of cranberries’ bioactive compounds on CRF and human health. Cranberry supplementation has been demonstrated in clinical research to offer health advantages for humans, such as reducing urinary tract infections. Recently, it has been reported that cranberry polyphenols possess anti‐inflammatory and antioxidant effects and are also known to have the capacity to affect gut flora. Scientific studies on the beneficial pharmacological effects of cranberries on human health may provide an understanding of traditional cranberry therapy in chronic kidney disease and other chronic conditions. However, translational studies are needed to determine the exact dose that can be administered to humans as well as the validation of nutritional supplements that contain cranberry extract.
Rational Synthesis of an Unsymmetric Pt Complex Unit Having Two Kinds of Pyrazolate Ligands: Elucidating Steric and Electronic Effects of Pyrazolate Ligands in Pt‐Ag Sandwich Complexes
Authors: Horiuchi Shinnosuke , Yang Yiming , Ueda Misa , Sakuda Eri , Arikawa Yasuhiro , Umakoshi Keisuke 
Published: September 2022

AbstractHerein we report the rational synthesis of an unsymmetric Pt complex containing two different pyrazole ligands and a selective formation of Z‐shaped Pt2Ag2 complex using the unsymmetric Pt complex unit, whose structures were undoubtedly revealed by X‐ray crystallographic analysis in the solid state and NMR analysis in the solution state. The selective formation of the unsymmetric Pt and Pt2Ag2 complexes enable us to reveal that the steric effect from the pyrazole ligands determine the orientation of the Pt complex units but hardly influence on the photophysical properties of the complexes. The TD‐DFT calculations of the Pt and Pt2Ag2 complexes supported the small electronic contributions of pyrazole moieties. This synthetic route will build up a new strategy to obtain new types of precious metal sandwich complexes.
Electrochemical Immunosensors: The Evolution from Elisa to EμPADs
Authors: Ochoa‐Ruiz Andrea Gabriela , Parra Guillermo , López‐Espinoza Diego , Astudillo Pablo , Galyamin Dmitry , Sabaté Neus , Esquivel Juan Pablo , Vallejo‐Cardona Alba Adriana 
Published: September 2022

AbstractElectrochemical immunosensors comprise the merging of two different disciplines: molecular biology and electrochemistry. This review explains in depth the main parts of electrochemical immunosensors and how the enzyme‐linked immunosorbent assay (ELISA) has been integrated into sophisticated “lab‐on‐a‐chip” and “point‐of‐care” devices. It also reviews how nanotechnology has been a powerful tool for achieving lower detection limits, more signal amplification, and constructing label‐free devices. It finally explores the new perspectives on electrochemical immunosensors to integrate them in novel paper microfluidic devices called EμPADs. Colleagues introducing themselves to the topic for the first time will find in this review a comprehensive revision of how the basics of the technology have given rise to the emerging topic of EμPADs.
Validierung des anisotropen visko ISA Modells (AVISA) für bindige Böden
Authors: Tafili Merita , Triantafyllidis Theodoros , Wichtmann Torsten 
Published: September 2022

AbstractDas Bauen auf bindigen Böden stellt trotz fortgeschrittener Ausführungstechnologien immer noch eine Herausforderung dar. Vor allem sind die Werkzeuge zur Prognostizierung der Langzeitverformungen des feinkörnigen Bodens beschränkt, wenn es um zyklische Belastungszustände in Verbindung mit dem zeitabhängigen Verhalten bindiger Böden geht. Solche Fragestellungen ergeben sich z. B. bei Offshore‐Konstruktionen oder auch bei Staumauern oder Widerlagern von Brückenkonstruktionen. Aufgrund des komplexen Einflusses der Belastungsrate, der Vorbelastung und der Struktur des Bodens ist es notwendig, die Auswirkungen dieser Einflüsse auf bindige Materialien durch Laborversuche zu verstehen und durch akkurate und physikalisch basierte konstitutive Gleichungen numerisch zu beschreiben.In diesem Aufsatz soll ein neues Modell, entwickelt in der Promotion der Erstautorin, validiert werden. Die Leistung des anisotropen visko ISA Modells (AVISA) wurde bisher an Experimenten verschiedener feinkörniger Böden unter Beweis gestellt. Hier wird eine neue experimentelle Studie an Malaysia Kaolin für die Validierung des Modells benutzt. Außerdem wird die Reproduzierbarkeit der sog. Krey‐und‐Tiedemann‐Parameter
, c′ und φ′ durch Simulationen von einfachen Rahmenscherversuchen untersucht.
Therapeutic plasma exchange in gastric signet ring cell carcinoma presenting as microangiopathic hemolytic anemia: A rare case report
Authors: Candar Omer , Ekinci Omer , Merter Mustafa , Aslan Mehmet , Aras Ibrahim 
Published: September 2022

AbstractMicroangiopathic hemolytic anemia (MAHA) defines a group of disorders characterized by the formation of microthrombi in capillaries and arterioles and the fragmentation of erythrocytes that pass through. Cancer‐related MAHA is a rare but serious condition that is encountered in patients diagnosed with a malignancy. This clinical picture is thought to be linked to certain tumor characteristics; particularly, adenocarcinoma histology, vascular invasion, and bone marrow infiltration. MAHA is most commonly associated with tumors of gastric, prostate, and breast origin. The optimal treatment is not clear; however, there is evidence for the importance of promptly starting an effective antineoplastic regimen and it was also reported that administering therapeutic plasma exchange (TPE) therapy for immunocomplex removal could be beneficial for patients with symptoms of bleeding and thrombosis. Here, we present a case that presented a picture of MAHA secondary to gastric signet‐ring cell adenocarcinoma (SRCC). The clinical picture was initially evaluated as thrombotic thrombocytopenic purpura and the patient benefited significantly from the TPE treatment administered before the adenocarcinoma diagnosis was confirmed. In this period, epistaxis stopped, platelet count increased from 25 × 109/L to 162 × 109/L, fragmented erythrocyte rate in the peripheral smear decreased by more than 75% and other laboratory findings of hemolysis (LDH, bilirubin, etc.) significantly improved.
Readiness to implement screening, brief intervention, and referral to treatment in school‐based health centers
Authors: Sebastian Rachel A. , Gunderson Lara M. , Ramos Mary M. , Willging Cathleen E. 
Published: September 2022

AbstractThe purpose of this study was to evaluate the readiness of a university‐based school‐based health center (SBHC) program to implement the screening, brief intervention, and referral to treatment (SBIRT) model. We completed preimplementation surveys and interviews with providers, staff, and administrators at participating SBHCs (N = 19) to measure current protocols for and barriers to addressing adolescent substance use and barriers and facilitators to implementing SBIRT. We used the R = MC2 heuristic (readiness equals motivation, general organizational capacity, and innovation‐specific capacity) to interpret findings from the data. Using the R = MC2 heuristic, we identified factors that may aid implementation, including the prioritization of substance use and a supportive organizational culture, as well as potential barriers, including competing high‐priority health issues and a lack of resources for innovation. This study contributes to the emerging literature on the implementation of the SBIRT model with adolescents and in SBHCs and demonstrates the practical applicability of the R = MC2 heuristic for assessing implementation readiness. SBHCs are ideal locations for addressing substance use but SBHC providers also face unique challenges when implementing the SBIRT model.
Conflicts in the framing of conflicts: The case of community investment in a mining company in the Democratic Republic of the Congo
Authors: Mària Josep F. , Goodman Jennifer 
Published: September 2022

AbstractConflict in firm–community relations is widespread and persistent. Diverse cultures and mindsets, particularly among extractives companies and local communities, pose a particularly challenging environment. Previous research offers insights into how to categorise and resolve conflicts. However, this paper addresses conflicts where the actors involved disagree on the frame of the conflict, thereby rendering the associated solutions inappropriate for one or both of the parties involved. We use examples from the Social Community Fund of a mining firm in the DRC to nuance previous work on conflict frames and develop a revised model that has implications for theory and practice.
Circulating rotavirus P[8]‐lineage IV, unlike P[8]‐lineage III, significantly related to nonsecretors status in Iranian children
Authors: Farahmand Mohammad , Latifi Tayebeh , Kachooei Atefeh , Jalilvand Somayeh , Shoja Zabihollah 
Published: September 2022

AbstractRotavirus (RV) P[8] strains are responsible for the most of the RV infections globally and are significantly associated with the secretor and Lewis positive status. Among the distinct P[8] lineages, different ligand affinities have been detected which can be linked to differences in secretor status associated histo‐blood group antigens (HBGAs). Herein, we report the lineages of P[8] strains and their associated secretor and Lewis antigen phenotypes in Iranian children. The phylogenetic tree and sequence analyses showed that the most common detected RV P[8] strain belonged to P[8]‐lineage III (92%) and were significantly associated with secretor and Lewis positive status. In contrast, 8% of P[8] strains clustered into the P[8]‐lineage IV and were significantly associated with nonsecretor status, implying that lineage IV tends to infect nonsecretor individuals. Furthermore, protein modeling and amino acid analyses of the VP8* glycan binding site of Iranian P[8]‐lineage IV strains indicated two residual substitutions (T184V and N216V/I) compared to the P[8]‐lineage III strains that might have affected the glycan affinity among P[8]‐lineages IV strains. The corresponding residual changes might permit their continued transmission in nonsecretor children in competition with other P[8]‐lineages. Although nonsecretors show natural resistant to P[8] strains, but such residual changes might overcome this natural resistance which in turn might indirectly contribute to the decline in the vaccine efficacy in populations where HBGA polymorphism allows their circulation at high frequency.
Global scenario of Plasmodium vivax occurrence and resistance pattern
Authors: Kaur Davinder , Sinha Shweta , Sehgal Rakesh 
Published: September 2022

AbstractMalaria caused by Plasmodium vivax is comparatively less virulent than Plasmodium falciparum, which can also lead to severe disease and death. It shows a wide geographical distribution. Chloroquine serves as a drug of choice, with primaquine as a radical cure. However, with the appearance of resistance to chloroquine and treatment has been shifted to artemisinin combination therapy followed by primaquine as a radical cure. Sulphadoxine‐pyrimethamine, mefloquine, and atovaquone‐proguanil are other drugs of choice in chloroquine‐resistant areas, and later resistance was soon reported for these drugs also. The emergence of drug resistance serves as a major hurdle to controlling and eliminating malaria. The discovery of robust molecular markers and regular surveillance for the presence of mutations in malaria‐endemic areas would serve as a helpful tool to combat drug resistance. Here, in this review, we will discuss the endemicity of P. vivax, a historical overview of antimalarial drugs, the appearance of drug resistance and molecular markers with their global distribution along with different measures taken to reduce malaria burden due to P. vivax infection and their resistance.
WHO SHOULD LEAD DIVERSITY & INCLUSION EFFORTS? NOT WHO YOU THINK
Authors: Rodgers James O. 
Published: September 2022

AbstractRodgers says that the most important elements of effective leadership are clarity and vulnerability. He further says that he defines leadership as “selling an idea, concept, or vision so that people willingly follow. When it comes to Diversity & Inclusion/D&I, leaders must be clear about what they see as possible and what they want for their followers. The problem seems to be that too few leaders have a clear concept of diversity and inclusion.” He purposely does not use the term inclusion in this construct: “Notice that I use the term D&I (diversity and inclusion). I introduced the term diversity management in the early 2000s as an indication that D&I has the capacity to improve enterprise performance. I now encourage others to stick with the term D&I and avoid the perpetual language roulette (changing terms without changing outcomes) and word salad (equity [E], belonging [B], justice [J], acceptance [A], empathy [E], etc.). The temptation to change the language when progress is elusive must be resisted.” In his words, D&I is a change effort that includes the following competencies, which in his words are Change management, Conceptual clarity, Relationship building, Leadership skills, Strategy and execution, Trust building, and Language skills.
THE SHARED SISTERHOOD PHILOSOPHY FOR EQUITY IN ORGANIZATIONAL LEADERSHIP
Authors: Opie Tina , Livingston Beth A. 
Published: September 2022

AbstractThe authors, in trying for better approaches to racial and gender equity, discuss what they call the “Shared Sisterhood” philosophy and approach on “how to achieve equity across genders and racioethnicity (i.e., race + culture combined) grounded in deep introspection and authentic interpersonal connection. In the workplace, equity is achieved via collective action, which means that you work with your coworkers to attain a common goal of equity.” They also note problems that the DEI/diversity, equity, and inclusion industry has had in organizations, even in today’s landscape where we have greater overall awareness of these topics. “With Shared Sisterhood,” they write, “we ask whether the power to change lies in growing and connecting with others and using those connections to foment the dismantling of systemic inequities.” They outline various steps individuals can take, each of which is described in more detail in the article. Some are, in their words: Keep reading; Follow people from different racioethnic groups on social media; and engage with different news sources. These are followed by interpersonal steps, such as Create book clubs or discussion circles to practice Shared Sisterhood exercises, and Create partnerships with other people to hold each other accountable for working toward equity.
ROS‐Responsive Glycopolymeric Nanoparticles for Enhanced Drug Delivery to Macrophages
Authors: Shofolawe‐Bakare Oluwaseyi T. , de Mel Judith U. , Mishra Sushil K. , Hossain Mehjabeen , Hamadani Christine M. , Pride Mercedes C. , Dasanayake Gaya S. , Monroe Wake , Roth Eric W. , Tanner Eden E. L. , Doerksen Robert J. , Smith Adam E. , Werfel Thomas A. 
Published: September 2022

AbstractMacrophages play a diverse, key role in many pathologies, including inflammatory diseases, cardiovascular diseases, and cancer. However, many therapeutic strategies targeting macrophages suffer from systemic off‐target toxicity resulting in notoriously narrow therapeutic windows. To address this shortcoming, the development of poly(propylene sulfide)‐b‐poly(methacrylamidoglucopyranose) [PPS‐b‐PMAG] diblock copolymer‐based nanoparticles (PMAG NPs) capable of targeting macrophages and releasing drug in the presence of reactive oxygen species (ROS) is reported. PMAG NPs have desirable physicochemical properties for systemic drug delivery, including slightly negative surface charge, ≈100 nm diameter, and hemo‐compatibility. Additionally, due to the presence of PPS in the NP core, PMAG NPs release drug cargo preferentially in the presence of ROS. Importantly, PMAG NPs display high cytocompatibility and are taken up by macrophages in cell culture at a rate ≈18‐fold higher than PEGMA NPs—NPs composed of PPS‐b‐poly(oligoethylene glycol methacrylate). Computational studies indicate that PMAG NPs likely bind with glucose transporters such as GLUT 1/3 on the macrophage cell surface to facilitate high levels of internalization. Collectively, this study introduces glycopolymeric NPs that are uniquely capable of both receptor‐ligand targeting to macrophages and ROS‐dependent drug release and that can be useful in many immunotherapeutic settings.
Foreign firms in the industry frontier and productivity convergence: Importance of proximity and firm attributes
Authors: Sarker Bibhuti 
Published: September 2022

AbstractThis study examines how size and other firm attributes explain establishment‐level productivity catch‐up using an establishment‐level panel dataset from Chile. Results suggest overall productivity convergence with comparatively slower rate to the foreign‐owned component in the frontier. Firms that are small in size, non‐exporter, non‐importer, and low technology‐concentrated demonstrate greater catch‐up rate. Additionally, foreign‐invested firms (FIFs) exhibit faster catch‐up rate to the industry frontier than their domestic counterparts. Finally, geographic proximity to the frontier significantly boosts the catch‐up rate. Results are robust to the inclusion of firm‐level control variables and sample selection bias, and the estimated catch‐up rate is not sensitive to sample size.
Diagnosis and treatment of MN1 C‐terminal truncation syndrome
Authors: Yu Jingjia , Li Chen , Chen Jialin , Ran Qiuchi , Zhao Yingya , Cao Qingxin , Chen Ximeng , Yu Linnan , Li Wenyang , Zhao Zhenjin 
Published: September 2022

AbstractBackgroundMN1 C‐terminal truncation (MCTT) is a rare syndrome; only 27 cases have been reported. We report the first case of an 8‐year‐old girl with MCTT syndrome complicated with moderate obstructive sleep apnea (OSA).MethodsMCTT syndrome was diagnosed by whole‐exome sequencing (WES) and validated by Sanger sequencing. The patient received 2 years of treatment with continuous positive airway pressure (CPAP) to relieve sleep apnea and hypoxia, and a reverse sector fan‐shaped expander for maxillary expansion.ResultsWES revealed a de novo MN1 variant, c.3760C>T (p.[Q1254*]). An arachnoid cyst was found in the right occipital brain. The patient presented mild symptoms of classic MCTT syndrome. The patient did not experience hearing loss and only mild intellectual disability. Radiological examinations showed cleft secondary palate, narrow upper arch, narrow upper airway, and mandibular skeletal retrusion. Polysomnography indicated moderate OSA, with an apnea/hypopnea index of 6.8, which decreased to 1 after CPAP during the night. Two‐year maxillary expansion widened the upper arch, and the cleft secondary palate became visible. The mandible moved forward spontaneously, resulting in the improvement of profile and upper airway widening. General physical conditions, such as motor delay, muscle weakness, and developmental delay, were significantly improved two years later.ConclusionIn conclusion, we discovered a MN1 variant [NM_002430.2: c.3760C>T, p.Q1254*] that causes mild MCTT symptoms compared to other MN1 variants. For patients with MCTT complicated with OSA, multidisciplinary combination therapy can improve maxillofacial development, widen the upper airway and relieve sleep apnea, improving the general physical condition.
Blue fibers found in dental calculus from Maya sacrificial victims
Authors: Chan Amy M. , Brady James E. , Scott Cummings Linda 
Published: September 2022

AbstractSurveyed in 2008–2010, the Midnight Terror Cave contains the comingled remains of at least 118 Maya sacrificial victims from the Classic Period (250 CE–925 CE). In order to determine what the victims were consuming, microscopic analysis was carried out on dental calculus. Given the minimal calculus present, calculus from three teeth from one area of the cave (operation V) and three teeth from another area (operation VIII) was each combined to create two samples for analysis. Samples were sent to the PaleoResearch Institute for analysis where they were examined for pollen, phytoliths, starches, and other inclusions.Aside from organic components, both samples were found to contain blue fibers. We were able to exclude contamination as explanation for their presence. Given the time frame needed to encase the fibers within calculus, the fibers were introduced several days or weeks prior to death. The unusual color of the fibers could be attributed to Maya blue; a unique pigment used mainly in ritual settings. A few possible answers exist as to how the fibers were introduced to the victims' mouths. The fibers could be from consuming a blue‐dyed pulque. They could also have been introduced during utilitarian activities or through some form of dentistry. Another possible explanation is that the fibers were present after using gags as the victims were paraded from town to town, then to the sacrificial site.