bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects
Authors: Adámková Kristýna , Koval' Tomáš , Østergaard Lars H. , Dušková Jarmila , Malý Martin , Švecová Leona , Skálová Tereza , Kolenko Petr , Dohnálek Jan 
Published: September 2022

S1 nuclease from Aspergillus oryzae is a single-strand-specific nuclease from the S1/P1 family that is utilized in biochemistry and biotechnology. S1 nuclease is active on both RNA and DNA but with differing catalytic efficiencies. This study clarifies its catalytic properties using a thorough comparison of differences in the binding of RNA and DNA in the active site of S1 nuclease based on X-ray structures, including two newly solved complexes of S1 nuclease with the products of RNA cleavage at atomic resolution. Conclusions derived from this comparison are valid for the whole S1/P1 nuclease family. For proper model building and refinement, multiple lattice-translocation defects present in the measured diffraction data needed to be solved. Two different approaches were tested and compared. Correction of the measured intensities proved to be superior to the use of the dislocation model of asymmetric units with partial occupancy of individual chains. As the crystals suffered from multiple lattice translocations, equations for their correction were derived de novo. The presented approach to the correction of multiple lattice-translocation defects may help to solve similar problems in the field of protein X-ray crystallography.
Information transmission between energy commodities and emerging Asian stock markets during crises: an analysis of oil importing countries
Authors: Babar Maria , Ahmad Habib , Yousaf Imran 
Published: September 2022

PurposeThis study examines the information transmission (return and volatility spillovers) among energy commodities (crude oil, natural gas, Brent oil, heating oil, gasoil, gasoline) and Asian stock markets which are net importers of energy (China, India, Indonesia, Malaysia, Korea, Pakistan, Philippines, Taiwan, Thailand).Design/methodology/approachThe information transmission is investigated by employing the spillover index of Diebold and Yilmaz, using daily data for the period January 2000 to May 2021.FindingsA Strong connectedness is documented between the two classes of asset, especially during crisis periods. Our findings reveal that most of the energy markets, except gasoil and natural gas, are net transmitters of information, whereas all the stock markets, excluding Indonesia and Korea, are net recipients.Practical implicationsThe findings are helpful for portfolio managers and institutional investors allocating funds to various asset classes in times of crisis.Originality/valueAll data is original.
The influence of Islamic leadership on work performance in service industry: an empirical analysis
Authors: Zaim Halil , Erzurum Erdem , Zaim Selim , Uluyol Burhan , Seçgin Gökhan 
Published: September 2022

Purpose
This study aims to propose a practical, virtue-centric model of leadership based on Islamic principles. The structure of the Islamic leadership construct is validated through confirmatory factor analysis. Its relationship with performance and organizational commitment is examined and the mediating role of organizational commitment is assessed.

Design/methodology/approach
Islamic leadership model is tested using confirmatory factor analysis with data collected from employees working in the services sector in Turkey. Relationships between Islamic leadership, organizational commitment and performance are examined through a path analysis.

Findings
The factor analysis results presented a good fit for the proposed Islamic leadership model, which consists of wisdom, religiosity, justice and kindness dimensions. Regarding path analysis, findings indicated a positive relationship between Islamic leadership and job performance. Moreover, organizational commitment partially mediated the relationship between Islamic leadership and job performance.

Originality/value
Previous studies on Islamic leadership contain a very little number of empirical models. This study proposes a valuable empirical model of Islamic leadership consisting of moral values, spirituality, ethics and wisdom. In addition, the proposed model is supported with empirical pieces of evidence. Evidence of the partial mediating role of organizational commitment between Islamic leadership and job performance is also revealed by the study.
Customer experience dimensions in last-mile delivery: an empirical study on unattended home delivery
Authors: Olsson John , Hellström Daniel , Vakulenko Yulia 
Published: September 2022

PurposeThe success of last-mile delivery is dependent on consumer acceptance of such services, yet little is known about unattended delivery experience. This paper's purpose is to provide empirically based understanding of customer experience dimensions in unattended home delivery.Design/methodology/approachUsing an engaged scholarship approach, this field study investigated nine households that actively used an unattended delivery service for a period of six to nine months. Empirical data were collected primarily from in-depth interviews.FindingsThe study demonstrates that unattended delivery experience is a multidimensional construct that comprises consumers' cognitive, emotional, behavioral, sensorial, physical and social responses to the service. The empirical evidence provides rich descriptions of each customer experience dimension, and the research offers a framework and propositions on unattended delivery experience.Practical implicationsThe results guide and support managers in assessing and developing delivery services using a consumer-centric approach to enhance customer experience.Originality/valueThis research is one of the first to address unattended delivery experience by providing a comprehensive, empirically grounded framework. The results provide a foundation for future investigations of last-mile delivery experience dimensions.
Ambidexterity and absorptive capacity in boundary-spanning managers: role of paradox mindset and learning goal orientation
Authors: Snehvrat Saurav , Chaudhary Sanjay , Majhi Siddharth Gaurav 
Published: September 2022

PurposeBoundary-spanning managers need to recognize, learn and implement external knowledge while balancing the conflicts emerging from new and existing knowledge. The authors' study explores how a paradox mindset (PM) and a learning focus [learning goal orientation (LGO)] promote two managerial capabilities: absorptive capacity (ACAP) and ambidexterity. The authors' study explores the inter-relationship between the mindsets and the capabilities required for innovative work behavior.Design/methodology/approachThe authors use survey data from 113 technology/product managers employed in boundary-spanning roles in a large Indian automotive equipment manufacturing firm. Partial least squares structural equation modeling (PLS-SEM) analysis and bootstrapping (using PROCESS MACRO) are used to test for direct and mediation effects respectively.FindingsBoth PM and LGO are found to affect individual ambidexterity (IA) via the mediation of individual absorptive capacity (IACAP). While IACAP partially mediates the relationship between PM and IA, there is full mediation in the case of LGO.Research limitations/implicationsThe authors focus on a sample of managers from a single, large Indian automotive firm. Although single case studies can help provide novel conceptual insights and to test theoretical relationships, future research needs to confirm the authors' findings in different types of firms.Practical implicationsThis study shows how a learning orientation and the ability to be energized from conflicts help boundary-spanning managers produce innovative outcomes.Originality/valueThe authors reveal fresh insights on how both ACAP and ambidexterity share the focus on learning and paradox management. The authors explicate how LGO and PM uniquely impact the critical capabilities of IACAP and IA for boundary-spanning managers.
Cycle Pure Agarbathies: branding fragrance across the world
Authors: Padmanabhan N.S. , Siji Smitha , Minimol M.C. 
Published: September 2022

Theoretical basis
This case facilitates the learning of marketing concepts like segmentation, targetting and positioning, marketing mix, branding strategies and digital marketing strategies.

Research methodology
The case is written based on the facts available in the public domain and hence it follows secondary data research design. The secondary sources include company websites, industry reports, newspaper articles, social media sites and other online articles and reports. The case is classroom tested with MBA students in digital marketing course and PGDM students in brand management course.

Case overview/synopsis
Cycle Pure agarbathi, the leading brand of NR Group, became the coveted brand among the households of India. This success amidst high competition can be attributed to the concerted effort on product development coupled with mindful branding. To keep abreast of time and competition the company opted to go digital with an e-portal. Cycle Pure had a digital presence much earlier through social media, but the e-portal www.cycle.in, was a novel attempt. All the fragrance products of the brand were available for consumers through www.cycle.in. Moreover, the product assortment consisted of a collection of top-quality products and auxiliaries linked to multiple categories such as invocation necessities, personal care, air care and lifestyle. Furthermore, using in-house fragrance research lab, the company experimented with local aromas through numerous variants and also extended to related products such as sambrani (benzene) and dhoops. With consistent product augmentations along with access to innovative sectors such as air fresheners, the company expected to grow at a rate of 15%–16% annually. However, the company targeted to grab one-third share in the total market within the next five years.

Complexity academic level
This case can be used in Marketing Management, Brand Management, Digital marketing and Strategic Marketing courses at the Master’s level. It is suitable for MBA and executive MBA students.
Observation: its role in Anna Freud’s developmental approach and therapeutic parent‐toddler groups1
Authors: Pretorius Inge‐Martine 
Published: September 2022

AbstractStarting in Vienna in the 1920s, Anna Freud’s first tentative attempts at observing children became a crucial component of the ‘double approach’ which integrated direct child observation with psychoanalytic reconstruction. This enabled the detailed study of unfolding developmental processes and the construction of a theory of normative as well as pathological child development. Her identification of disturbances that were developmental rather than neurotic led to the broadening of child analysis. Interventions aimed at freeing and supporting development rather than giving insight, became known as ‘developmental therapy’. These interventions are used in the parent‐toddler groups that embody Anna Freud’s endeavour to link psychoanalytic theory, direct observation and clinical practice. Observations of a toddler, who attended a parent‐toddler group with his mother, show how intervening early in the child’s life and soon after concerns were identified, contributed to preventing maladaptive affective states and ways of relating from becoming entrenched.
Thinking the unthinkable: trauma, defence and early states of mind in the work of Alessandra Cavalli1
Authors: Colman Warren 
Published: September 2022

AbstractFrom my experience of working with her as the editor of many of her papers, this paper seeks to elucidate the late Alessandra Cavalli's clinical and theoretical approach to analytic work through a study of the editorial process her papers went through on their way to publication. This highlights a consistent theoretical synthesis integrating Klein, Fordham, Bion, Matte‐Blanco and Ferrari in an archetypal structure that was firmly rooted in Jung. This synthesis, closely interwoven into Alessandra's clinical work but never fully articulated, was primarily concerned with the impact of trauma on the developing self and how this could be ameliorated through the analytic process, especially through the transformation of raw primitive affect into representational form via the containment provided by an emotionally attuned other.
Therapeutic plasma exchange in anti‐N‐methyl‐D‐aspartate receptor encephalitis
Authors: Zhang Yuan , Cheng Yong‐kang , Yang Chun‐feng , Jin Lin‐mei , Li Yu‐mei 
Published: September 2022

AbstractAnti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) encephalitis is the most commonly identified cause of autoimmune encephalitis. Therapeutic plasma exchange has been increasingly employed to treat this disease. This expansion is a consequence of improved techniques and apheresis instruments, as well as the recognition of its applicability in neurological diseases. However, several aspects of treatment remain incompletely clarified, and treatment strategies are still heterogeneous, especially with regard to therapeutic plasma exchange in anti‐NMDAR encephalitis. This review provides an overview of the use of therapeutic plasma exchange including the principle and mechanisms, the evidence, initial time, efficiency and complications in anti‐NMDAR encephalitis.
Integrating 18F‐FDG PET/CT with lung dose‐volume for assessing lung inflammatory changes after arc‐based radiotherapy for esophageal cancer: A pilot study
Authors: Hsu Chen‐Xiong , Lin Kuan‐Heng , Shueng Pei‐Wei , Wu Yen‐Wen , Tsai Wei‐Ta , Chang Chiu‐Han , Tien Hui‐Ju , Wang Shan‐Ying , Wu Tung‐Hsin , Mok Greta S. P. 
Published: September 2022

AbstractObjectiveThe incidence of radiation pneumonitis (RP) has a highly linear relationship with low‐dose lung volume. We previously established a volume‐based algorithm (VBA) method to improve low‐dose lung volume in radiotherapy (RT). This study assessed lung inflammatory changes by integrating fluorine‐18‐fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT) with VBA for esophageal cancer patients undergoing arc‐based RT.MethodsThirty esophageal cancer patients received 18F‐FDG PET/CT imaging pre‐RT and post‐RT were included in a retrospective pilot study. We fused lung doses and parameters of PET/CT in RT planning. Based on VBA, we used the 5Gy isodose curve to define high‐dose (HD) and low‐dose (LD) regions in the lung volume. We divided patients into non‐RP (nRP) and RP groups. The maximum, mean standardized uptake value (SUVmax, SUVmean), global lung glycolysis (GLG), mean lung dose (MLD) and V5–30 in lungs were analyzed. Area under the curve values were utilized to identify optimal cut‐off values for RP.ResultsEleven patients in the nRP group and 19 patients in the RP group were identified. In 30 RP lungs, post‐RT SUVmax, SUVmean and GLG of HD regions showed significant increases compared to values for pre‐RT lungs. There were no significant differences in values of 22 nRP lungs. Post‐RT SUVmax and SUVmean of HD regions, MLD, and lung V5 and V10 in RP lungs were significantly higher than in nRP lungs. For detecting RP, the optimal cut‐off values were post‐RT SUVmax > 2.28 and lung V5 > 47.14%.ConclusionThis study successfully integrated 18F‐FDG PET/CT with VBA to assess RP in esophageal cancer patients undergoing RT. Post‐RT SUVmax > 2.28 and lung V5 > 47.14% might be potential indicators of RP.
Suicidality and relief of depressive symptoms with intermittent theta burst stimulation in a sham‐controlled randomized clinical trial
Authors: Wilkening Jonas , Witteler Fabian , Goya‐Maldonado Roberto 
Published: September 2022

AbstractObjectivesSuicidality is a serious public health problem and is closely associated with the severity of depression. In this work, we examined the effects of accelerated intermittent theta burst stimulation (iTBS) on suicidal status, risk factors for suicide, and severity of depressive symptoms in subjects with major depressive disorder (MDD).MethodsWe present data from a quadruple‐blind (patient, care provider, investigator, rater) sham‐controlled crossover randomized clinical trial. During a 6‐week observation period, each participant underwent 2 weeks of stimulation ‐ each week with 20 sessions of active or sham iTBS. A suicide score was created using a composite of individual items from Montgomery–Åsberg Depression Scale (MADRS), Hamilton Depression Scale, and Beck Depression Inventory. The severity of depression was determined by MADRS total scores. In addition, we used demographic and Columbia Suicidality Rating Scale information to assess suicide risk.ResultsAmong 81 participants, we observed a significant reduction in suicidality and this change was positively correlated with a change in depressive symptoms. A significant difference between active and sham iTBS provided evidence for antidepressant effects. Higher changes in levels of anxiety and impulsiviness also correlated with larger changes in suicidality.ConclusionsAs neither suicide nor other serious adverse events were evidenced, this intervention was a safe and viable procedure to reduce suicidality and severity of depressive symptoms. Moreover, we identified more pronounced anti‐suicidal effects in those with higher risk profiles. Unlike MADRS, composite suicidal scores did not provide evidence of an effect between stimulation conditions in this crossover design study. Even so, based on our promising results, parallel and larger studies could contribute to a better characterization of the anti‐suicidal placebo effect and the benefit of using iTBS against suicidal symptoms.
Effect of board gender diversity on the financial performance of microfinance institutions: Does judicial efficiency matter?
Authors: Sarpong‐Danquah Beatrice , Adusei Michael , Magnus Frimpong Joseph 
Published: September 2022

AbstractThe impact of board gender diversity on the financial performance of firms is not known. This is because empirical investigations have yielded inconclusive outcomes. This study engages data from 408 microfinance institutions (MFIs) covering the period 2010–2018 from the six microfinance regions to investigate this impact using the Least Squares Dummy Variable (LSDV) and the System Generalized Method of Moments (SYS‐GMM) estimation techniques. The study also explores whether judicial efficiency exerts any significant effect on the board gender diversity–financial performance nexus. The study observes that board gender diversity exhibits a strong negative effect on the financial performance of MFIs. The study also observes that the effect of board gender diversity on the financial performance of MFIs escalates in the presence of judicial inefficiency. The study, therefore, unveils the judicial system as a channel through which gender diversity drives the financial performance of MFIs negatively.
Reporting and Assurance of Climate‐Related and Other Sustainability Information: A Review of Research and Practice
Authors: Zhou Shan 
Published: September 2022

AbstractThis literature review provides a summary of the key insights from recent studies that use an archival method. It covers two subject matters: climate‐related information and other sustainability information. For each, the paper reviews and summarises findings on current practices and the determinants and consequences of the reporting and assurance of climate‐related and other sustainability information in both voluntary and mandatory regimes. The review identifies areas that are close to saturation and those that are currently under researched. It also highlights key trends in this evolving area for future research to explore.
How conceptualizing obesity as a disease affects beliefs about weight, and associated weight stigma and clinical decision‐making in health care
Authors: Rathbone Joanne A. , Cruwys Tegan , Jetten Jolanda , Banas Kasia , Smyth Lillian , Murray Kristen 
Published: September 2022

AbstractObjectivesThis study empirically investigated how conceptualizing obesity as a disease (i.e., pathologizing obesity) affects beliefs about weight, and weight stigma and discrimination among health professionals.DesignAn experiment that manipulated the pathologization of obesity was completed by a multi‐nation sample of health professionals from Australia, UK, and USA (N = 365).MethodsParticipants were randomly assigned to one of two conditions where they were asked to conceptualize obesity as a disease or not a disease; then presented with a hypothetical medical profile of a patient with obesity who was seeking care for migraines. We measured biogenetic causal beliefs about obesity, endorsement of weight as a heuristic for health, negative obesity stereotypes, and treatment decisions.ResultsParticipants in the disease (vs. non‐disease) condition endorsed biogenetic causal beliefs more strongly and made more migraine‐related treatment recommendations. No effect of the manipulation was found for the remaining outcomes. Biogenetic causal beliefs about obesity were associated with less weight stigma. Endorsing weight as a heuristic for health was associated with greater weight stigma and differential treatment recommendations focused more on the patient's weight and less on their migraines.ConclusionsPathologizing obesity may reinforce biogenetic explanations for obesity. Evidence demonstrates complex associations between weight‐related beliefs and weight stigma and discrimination. Biogenetic causal beliefs were associated with less weight stigma, while endorsing weight as a heuristic for health was associated with greater weight stigma and differential treatment. Further research is needed to inform policies that can promote health without perpetuating weight‐based rejection in health care.