bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcranial Direct Current Stimulation Decreases P3 Amplitude and Inherent Delta Activity During a Waiting Impulsivity Paradigm
Authors: Mendes Augusto J. , Galdo-Álvarez Santiago , Lema Alberto , Carvalho Sandra , Leite Jorge 
Published: March 2022

Abstract
Background
One of the main features of addictive behaviors is the inability to wait for an action, that is, the waiting impulsivity. It has been suggested that potential therapeutic tools for addiction, such as transcranial Direct Current Stimulation (tDCS), might focus on this inability. Nonetheless, whereas there is consensus about the role of prefrontal cortex on impulsivity behavior, the effects of tDCS in waiting impulsivity and underlying electrophysiological (EEG) markers are still not clear.
Objective
The study aimed the neuromodulation of right inferior frontal gyrus during a task designed to elicit premature responses, while EEG markers important in reward anticipation (i.e., cue and target-P3 and underlying delta/theta activity) were studied.
Methods
Forty healthy subjects participated in two experimental sessions, where they received active and sham tDCS while performing a premature responding task and the EEG was recorded. At next, participants performed two control tasks to evaluate transfer effects for delay discounting and motor inhibition abilities.
Results
Active tDCS decreased amplitude in cue-P3, target-P3, and delta activity during target-P3. On the other hand, active tDCS increased the discounting of future rewards in small values in comparison with sham, while no tDCS effects were found in motor inhibition.
Conclusion
These findings suggest tDCS-induced modulation of the P3 component and underlying oscillatory activity during waiting impulsivity. Moreover, these changes were associated with differences in the discounting of future rewards. Thus, the current study suggests the usefulness of tDCS in modulating impulsive processes and the relationship between P3, the inherent delta activity, and reward processing.
Availability of Healthy Food, Alcohol, and Tobacco in a Rural Oklahoma Tribal Community
Authors: Jervis Lori , Bray Laura , Cox Derrell , TallBull Gloria , Lowery Bryce , Spicer Paul 
Published: March 2022

Abstract
Background: American Indians experience disproportionally high rates of diet-related metabolic disorders. Suboptimal retail food environments make obtaining healthy food difficult, particularly for rural American Indians, and contribute to ill health. Objective: This project examined food availability in food stores within a tribal community. Design: Audits were conducted of all retail stores that sell food within nine communities within the Cheyenne & Arapaho Tribal Jurisdictional Area.Main Measures: Freedman Grocery Store Survey and the Healthy Food Assessment Survey.Key Results: Local populations were often reliant on convenience and dollar stores that prominently featured alcohol, tobacco, and ultra-processed food—and offered very little fresh produce. Convenience stores comprised more than half of all area food stores and were the only source of food in one-third of the communities. Only larger communities had supermarkets that sold fresh produce as well as ultraprocessed food. Dollar stores stocked primarily alcohol, tobacco, and ultraprocessed foods, and were rapidly displacing local markets that sold fresh produce. In general, alcohol and tobacco were far more available than vegetables and fruits in food stores. Conclusions: The limited availability of healthy food helps to explain our previous findings on dysbiotic microbiomes in Cheyenne & Arapaho individuals. The predominance of convenience stores and the growth of dollar stores in the tribal jurisdictional area contributed to a suboptimal food environment.
In Silico Study of Physicochemical Characteristics and Anticancer Potential of Peptides Derived from Salvia Hispanica
Authors: Mendoza Luis Fernando Morales , Figueroa Sergio Hidalgo , Álvarez Alan Javier Hernández , Campos Maira Rubi Segura , Bojórquez Nidia del Carmen Quintal 
Published: March 2022

Abstract
Peptides derived from Salvia hispanica´s protein fraction < 1 kDa, were identified and analyzed for the prediction of their physicochemical properties. The characterized peptide sequences were then submitted to a multi-criteria decision analysis to identify the peptides that possess the characteristics to potentially exert anticancer activity. Through molecular docking analysis, the potential anticancer activity of the Potentially Anticancer Peptide (PAP)-1, PAP-2, PAP-3, PAP-4 and PAP-5, was estimated by their binding interactions with cancer and apoptosis related molecules. All five evaluated PAPs exhibited strong binding interactions (<-100 kcal/mol); however, PAP-3 showed the lowest binding free energies with several of the targets. Thus, PAP-3 shows potential to be used as a nutraceutical or ingredient for functional foods that adjuvates in cancer treatment. Further in vitro and in vivo studies are required to validate the predictions obtained by the in silico analysis, and to establish the mechanism of action and the clinical potential of the peptide.
Succinate Dehydrogenase Subunit B Regulates Cisplatin Resistance via DNA Damage in Human Ovarian Cancer Cells
Authors: Chen Lilan , Di Wen 
Published: March 2022

Abstract
BackgroundSuccinate dehydrogenase subunit B (SDHB) is one of succinate dehydrogenase subunits which is an important enzyme in the tricarboxylic acid (TCA) cycle. SDHB has been found expressed low in human ovarian carcinoma compared to human ovarian normal epithelium tissues. Previous studies have confirmed that the high expression of SDHB significantly inhibits the proliferation, invasion and migration of ovarian cancer cells, indicating that SDHB plays a role of tumor suppressor gene in ovarian cancer. But the role of SDHB in ovarian cancer chemotherapy is unknown.Methods Using the SDHB specific siRNA and overexpression plasmid, the expression of SDHB was silenced and conversely overexpressed in ovarian cancer cell lines SKOV3 and A2780, respectively. The role of SDHB in ovarian cancer chemotherapy was investigated in vitro, using CCK8 and Colony formation assays. Immunohistochemistry was used to exam the expression of SDHB in human ovarian cancer cisplatin-resistant tissues and corresponding cisplatin-sensitive tissues. To explore the mechanism, DNA damage repair related proteins such as γ-H2AX and ERCC1were examined by western blot in SKOV3 and A2780 cells.ResultsSDHB expressed lower in human ovarian cancer cisplatin-resistant tissues than the corresponding cisplatin-sensitive tissues. SDHB silencing increased drug resistance and SDHB overexpression showed the opposite results in SKOV3 and A2780 cells. In SDHB-silenced cancer cells, the level of ERCC1, which contributes to platinum drug resistance by promoting DNA repair, was increased, andγ-H2AX, which is related to cell apoptosis and drug resistance was decreased. Conclusions In this research, we demonstrated SDHB silencing reduced chemosensitivity in SKOV3 and A2780 by improving the repair of DNA damage. These results suggested that SDHB might represent a potential therapeutic target to overcome chemosensitivity in human ovarian carcinoma.
Effect of tourniquet technique on postoperative delirium in elderly patients with total knee arthroplasty: A Randomized Controlled Trial
Authors: ran wei , Li Shuzhen , Yuan Ruixue , Luo Huan , Li Ping , Gao Jin 
Published: March 2022

Abstract
Background: Tourniquet technique is often used in total knee arthroplasty (TKA), However, the effect on postoperative delirium (POD) in elderly patients with TKA procedure is still unknow.Methods: This prospective randomized controlled study assessed eligibility of 245 elderly patients, 197 patients met the inclusion criteria were randomly divided into tourniquet group (n=98) and non-tourniquet group (n=99). The primary outcome was the incidence of POD within 72 hours after surgery. The secondary outcome was the quality of rehabilitation, including inflammatory reaction, postoperative pain, hypoproteinemia and anemia.Results: Of 245 patients, 184 patients completed this clinical trial, 92 cases in each group. There were 14 patients (15.22%) with POD in tourniquet group and 5 patients (5.43%) in non-tourniquet group (95%CI 1.076 to 9.067, P=0.029). The changes of WBC, NEUT%, CRP, IL-6 and middle patellar circumference in tourniquet group were higher than those in non-tourniquet group (F=5.136, P=0.025 F=17.213, P<0.001 F=9.055, P=0.003 F=552.793, P<0.001 F=153.839, P<0.001). VAS at resting and activity in tourniquet group were higher than those in non-tourniquet group (F=170.102, P<0.001 F=75.391, P<0.001). There were 41 (44.57%) patients with hypoproteinemia in tourniquet group and 26 (28.26%) patients in non-tourniquet group (95%CI 1.106 to 3.765, P=0.022). Conclusion: The application of tourniquet technique in elderly patients with TKA procedure increased the incidence of POD, which may attribute to the increased inflammatory reaction, severe postoperative pain and hypoproteinemia caused by tourniquet technique. Trial registration: This prospective study (Ethics Committe and IRB number: 2019-338) was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University ,Chongqing, China (Chairperson Prof Hao Jie) on 23 April 2021 and registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn, Chictr2100045711) before the enrolment process started on 28 April 2021, The study adhered to the CONSORT guidelines and written informed consent was obtained from all subjects participating in the trial.
Dynamic Data Collection Algorithm based on Mobile Edge Computing in Underwater Internet of Things
Authors: Liu Chunfeng , Guang Xiaoyun , Qu Wenyu , Zhao Zhao 
Published: March 2022

Abstract
The Underwater Internet of Things (UIoT) hasemerged as one of the prominent technologies in the developmentof future ocean monitoring systems, where mobile edge elements(such as autonomous underwater vehicles, AUVs) provide apromising method for the data collection from sensor nodes.However, as an important part of the UIoT, underwater wirelesssensor networks (UWSNs) are severely affected by the underwater dynamic environment. For instance, node locations changecontinuously, which significantly increases the difficulty of datacollection. To solve this problem, the concept of an inevitablecommunication space (ICS) is proposed. The ICS is calculatedby analyzing the variation in the position of nodes and thecommunication range. Furthermore, an ICS-based dynamic datacollection algorithm (ICS-DDCA) for UIoT is proposed to collectunderwater data. This method utilizes the ICS instead of theinitial location of the node for data collection to further improvethe performance of the algorithm and shorten the data collectiontime. The simulation results demonstrate that the ICS-DDCAcan effectively reduce the collection time, while ensuring the fullcompletion of data collection. Compared to EEDA and PNCS-GHA, ICS-DDCA reduces the time required for data collectionby 24.15% and 24.22% on the average respectively.
Stone catcher device to improve management of urolithiasis. Calculstop Trial
Authors: Giaime Philippe , Pedinielli Nathalie , Chaumoitre Jérémie , Mustat Andrea , Sampol Jérôme 
Published: March 2022

Abstract
Urinary stones are a frequent situation, leading to high morbidity and health care costs. As a preventable disease, many diet modifications and sometimes pharmacologic interventions can avoid recurrence. The analysis of the stone is a cornerstone of the diagnosis, but is not made frequently, mainly because of practical considerations for the patients. There is no easy to use device. We tried a new medical device, Calculstop°, to catch the stone and keep it safe to the laboratory. We conducted a prospective study in 20 patients, showing 8 times more catching of the stone in recurrent cases. All patients who had catched the stone could have an analysis. The device also facilitated urinary pH measurement. We conclude that the device has been useful to help diagnosis and prevent recurrent stone.
Enhanced recovery after surgery (ERAS) program for elderly patients with anterior cervical discectomy and fusion (ACDF)
Authors: WANG QIANG , WANG PENG , KONG CHAO , TENG ZE , ZHANG SITAO , WANG SHUAIKANG , CUI PENG , SUN WENZHI , ZHAO GUOGUANG , LU SHIBAO 
Published: March 2022

Abstract
Background: Enhanced recovery after surgery (ERAS) is currently widely used in in many surgical specialties, but it is still lack of concerning the cervical ERAS program for elderly patients (>60 years old). We aimed to determine whether our ERASprogram significantly improved satisfaction and outcomes in elderly patients (>60 years old) with anterior cervical discectomy and fusion (ACDF). Methods: The study enrolled patients if they were over the age of 60 years old underwent under four levels ACDF. Data including demographic, comorbidity and surgical information were collected. We also evaluated ERAS process compliance, primary outcome, surgical complication and length of stay (LOS).Results: There were 135 patients in the ERAS group and 122 patients in the non-ERAS group were included. A comparison of the demographic data revealed that there were no statistically significant intergroup differences observed between the group. Overall, ERAS pathway compliance was 91.9%. There were no significant differences in the fusion levels、operative time、intraoperative blood loss、postoperative VAS score and complications between the ERAS and non-ERAS groups. In addition, there was no significant difference in readmission and mortality at 30-day follow-up between the two groups. However, we observed a statistically significant decrease in the LOS in the ERAS group (8.68±2.34 of ERAS group versus 10.43±4.05 in non-ERAS group, p=0.013). Conclusions: This report describes the first ERAS protocol used in elderly patients with ACDF. Our ERAS program is safe and associated with incremental benefits in respect to LOS in elderly patients with ACDF
Determinants of metabolic syndrome among type two diabetic patients following diabetic clinic of Arba Minch General hospital, southern Ethiopia- a case-control study
Authors: Abebe Getachew , Fikadu Teshale , Hailu Tadiwos , Temesgen Rodas 
Published: March 2022

Abstract
Purpose: Metabolic syndrome is a global public health issue that raises the risk of cardiovascular disease and early death. Globally, 70–80% of diabetic patient develop metabolic syndrome Comprehensive knowledge about risk factors for metabolic syndrome are essential to decrease the risk of cardiovascular diseases and improve the quality of life for diabetic patient. Thus, this study aims to determine predictors of metabolic syndrome among type two diabetic patients. This study aims to identify determinants of metabolic syndrome among type two diabetic patients.Methods: Facility-based unmatched case-control study was conducted among 204 systematically selected participants using a pre-tested, interviewer-administered questionnaire. Bivariate and multivariable logistic regression analyses were employed to identify determinants of metabolic syndrome using STAT version 16. Result: The probability of being female was 3.4 times higher among cases than controls as compared to being male [AOR=3.35, 95% CI (1.28, 8.73)]. The odds of being a rural dweller were 2 times higher among cases than controls as compared to rural dwellers [AOR = 3.10, 95% CI (1.27, 7.624)]. The likelihood being government employment was 4.4 times higher among cases than controls as compared to self-employed [AOR= 4.39, 95% CI ((1.28, 14.97)]. The odds of being obese were 2.7 times higher among cases than controls as compared to normal body mass index [AOR= 2.72, 95% CI ((1.03, 7.17)].Conclusion: -This study showed that sex, residence, occupation, and body mass index were found to be determinants of metabolic syndrome. Thus, concerned organizations and health professionals should focus on these factors in their efforts to reduce the risk of cardiovascular disease among diabetics.
Human languages trade off complexity against efficiency
Authors: Koplenig Alexander , Wolfer Sascha , Meyer Peter 
Published: March 2022

Abstract
One of the fundamental questions about human language is whether all languages are equally complex. To answer this long-standing question, we conduct a large scale quantitative cross-linguistic analysis of written language by training a language model on more than 6,500 different documents as represented in 41 multilingual text collections consisting of ~3.5 billion words or ~9.0 billion characters and covering 2,069 different languages that are spoken as a native language by more than 90% of the world population or ~46% of all languages that have a standardized written representation. Statistically inferring the entropy of each language-model as an index of (un)predictability/complexity allows us to refute the equi-complexity hypothesis, but also unveils a previously undocumented complexity-efficiency trade-off: high entropy languages are information-theoretically more efficient because they tend to need fewer symbols to encode messages. Our findings additionally contribute to debates about language evolution/diversity by showing that this trade-off is partly shaped by the social environment in which languages are being used.
Pure Arterial Malformation of the Left Middle Cerebral Artery: A Case Report
Authors: Fu Nian-xia , Song Jian-xun , Wu Ying-te , Lin Guo-hui 
Published: March 2022

Abstract
Background: Pure arterial malformations (PAMs) are rare intracranial vascular anomalies and involvement of the distal M3 segment of the middle cerebral artery are also uncommon. Diagnosis can become elusive when PAMs occur in atypical locations due to insufficient knowledge of the disease in spite of specific imaging characteristics. PAMs actually have a benign natural history and should be managed conservatively. We present a patient with a PAM of the left middle cerebral artery that was mistaken for an arteriovenous malformation and embolized.Case presentation: We report a case of pure arterial malformation of the left middle cerebral artery in a 41-year-old man with a two-day history of dizziness and limb convulsions. Preoperative MRI and DSA displayed the left middle cerebral artery was dilated, overlapping, and tortuous arteries forming a mass of arterial loops with a coil-like appearance. He was mistaken for an arteriovenous malformation and embolized.Conclusion: Our case highlights that intracranial vascular anomalies forming a mass of arterial loops lacking a venous component should be considered pure arterial malformations. Management and individual therapy are administrated to patient who are screened out PAMs.
Recurrent Infections Leading to DBS Removal but Reimplantation Achieving a Good Outcome: a Case Report
Authors: Li Tao , Wang Xiaoxi , Song Chunli , Ren Lu , Yin Xiaoxue , Pu Lanlan , Liang Zhanhua 
Published: March 2022

Abstract
Background: Deep brain stimulation (DBS) is an established treatment for patients with medical refractory Parkinson's disease (PD). DBS systems are implanted with the aim of providing permanent treatment, but infections, several early and late hardware related complications, suboptimal outcomes ,which might require revision operations with partial or even complete hardware removal. Here we described a surgical procedure with complete implants removal due to infections but reimplantation of a new DBS system achieved a good outcome in a patient with PD for over 20 years. Case presentation: A 70-year-old male with idiopathic PD for 22 years who underwent bilateral subthalamic nucleus (STN) DBS surgery with a non-rechargeable implantable pulse generator (IPG) when he was diagnosed PD for 8 years. His past history included hypertension and type 2 diabetes mellitus (DM). He underwent IPG replacement surgery in his 4th and 9th year after his initial DBS implantation. Four years after his latest IPG replacement surgery, he developed recurrent skin erosion around the DBS system. He underwent a total of four local incisions debridements (including two times of dissociated flap transplantation) and several sessions of antibiotic therapy before the final removal of the hardware. Fortunately after completion of antibiotic treatment, he underwent implantation of a new DBS system nine months later. No further complications appeared at the ninth months follow-up after reimplantation. The patient's symptoms had improved to a great extent, and he could take care of himself and his quality of life had improved significantly, which met the needs of the patient and his family.Conclusions: Infection is one of the most serious and difficult complications to manage after DBS implantation. Treatment of this complication can take a long time and lead to additional hospitalization, surgery and partial or total removal of the DBS system. However as long as the indications are met in any case, the reimplantation procedure can be reconsidered later, despite having had an infection and the electrode being removed.
TUCAN: A molecular identifier and descriptor applicable to the whole periodic table from hydrogen to oganesson
Authors: Brammer Jan C. , Blanke Gerd , Kellner Claudia , Hoffmann Alexander , Herres-Pawlis Sonja , Schatzschneider Ulrich 
Published: March 2022

Abstract
TUCAN is a canonicalization and serialization algorithm that is independent of domain-specific concepts of structure and bonding. Beyond the atomic number, all invariants used in the partitioning of a molecule are exclusively derived from the molecular topology and therefore make the algorithm also applicable to non-chemical graphs. In particular, the use of "fundamental" (chordless) cycles introduces an invariant of high discriminatory power which enables canonicalization of "difficult" graphs for which the popular Morgan algorithm fails. Extensive benchmarking is reported on a manually curated test set of molecules as well as a library of non-chemical graphs. In addition to the new canonicalization algorithm, the serialization procedure generates a unique "tuple-style" output which is fully bidirectional, allowing the TUCAN string to serve as both identifier and descriptor. Use of the Python NetworkX graph library facilitated a compact and easily extensible implementation.
Rehabilitation interventions for depression symptoms among cancer patients in Palestine: Literature review study.
Authors: Battat Maher , Marie Mohammad 
Published: March 2022

Abstract
Background Depression enhances disease burden in cancer patients, psychological interventions and rehabilitation of depression are required as a part of palliative care for cancer patients to improve the quality of life and mental healthThe aim of the study to review the literature about depression treatments and rehabilitation interventions among cancer patients in PalestineMethod: Review articles used electronic databases PubMed, Science Direct, Research Gate and Google Scholar to search for materials for the literature review study.Results: twenty three articles reviewed five of them from Arab and Islamic countries, and five articles from Palestine. Overall depression rehabilitation interventions for cancer patients are defined on two themes includes pharmacological interventions, and non-pharmacological interventions used that reduce depression symptoms and improve mental health among cancer patients. Depression rehabilitation interventions among cancer patients in Palestine are limited to palliative care perspective includes psychosocial support, cancer patient symptoms management, and family education. Conclusion: Depression symptoms treatments and rehabilitation interventions in Palestine are limited to non-pharmacological interventions from the perspective of palliative care for cancer patients including psychosocial interventions, besides cancer patient’s symptoms management affects mental health positively and depression recovery. Palliative care including depression symptoms rehabilitations in Palestine needs improvement. Israeli occupation is the main cause of limited rehabilitation and treatment interventions for Palestinian cancer patients.