bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attentional bias malleability as a predictor of daily pain interference
Authors: Todd Jemma , Clarke Patrick J.F. , Hughes Alicia Maria , van Ryckeghem Dimitri 
Published: August 2022

Abstract
Despite a preponderance of pain-related attentional bias research, little is known about how these biases arise and change over time. We tested whether the degree of attentional bias malleability, that is, ability to acquire and relinquish patterns of selective attention towards pain information, predicts daily pain interference. Individuals with chronic pain (N = 66) completed a novel attentional bias malleability procedure based on a modified dot-probe paradigm. Participants received a contingency that encouraged an attentional preference toward and away from pain words across 2 counterbalanced blocks, and attentional bias was assessed before and after each contingency block. Participants then completed a daily diary for 7 days, including the Patient-Reported Outcomes Measurement Information System-29 pain severity and interference. Multilevel modelling was conducted to predict daily pain interference from attentional bias malleability constructs, controlling for pain severity and demographic factors. Greater attentional bias (F1,391 = 3.97, P = 0.047), greater readiness to acquire an attentional bias (F1,389 = 4.92, P = 0.027), and less readiness to lose an acquired attentional bias toward pain (F1,354 = 5.18, P = 0.024) all predicted less pain interference. There was also an interaction between pain severity and overall attentional bias malleability (F1,62 = 5.48, P = 0.023), such that as pain severity increased, those who showed greater attentional bias malleability showed less corresponding increase in their pain interference than those who showed less attentional bias malleability. This study adds new thinking to the dynamic nature of attentional bias and how such biases might arise and influence pain outcomes.
Hemodynamic protective effects of epinephrine containing saline irrigation in biportal endoscopic lumbar surgery
Authors: Ko Woo-Hyeong , Cho Yong-Hyun , Jang Won , Kim Sun-Hee , Lee Hyun-Seok , Ko Hyun-Cheol , Kwon Jae-Hyun 
Published: August 2022

During endoscopic orthopedic surgery, epinephrine mixed with irrigation saline is frequently used to improve visualization. By monitoring hemodynamic parameters throughout the procedure, we intended to discover the hemodynamic effect of epinephrine between the normal saline irrigation fluid without epinephrine group (NS) and normal saline irrigation fluid with epinephrine group (EPI).
Patients who underwent 1-level lumbar decompression or discectomy surgery without fusion between August 2019 and July 2020 were reviewed retrospectively. The hemodynamic parameters were compared between the NS group and EPI group. As a second endpoint, the incidence of hypotension and hypertension events, expected blood loss, postoperative nausea and vomiting and postoperative epidural hematoma were compared between the 2 groups.
The 2 groups were homogeneous in terms of age, sex, weight, height, body mass index (BMI), ASA physical status (ASA PS), and diagnosis. The incidence of hypotension events (67.2 % in the NS group, 45.7 % in the EPI group, P =.015) and severe hypotension events (51.7 % in the NS group, 28.6 % in the EPI group, P = .015) were less frequent in the EPI group. Only epinephrine had a significant protective effect through a multivariable analysis (P = .027, OR = 2.361) and in severe hypotension events, only epinephrine had a significant protective effect through a multivariable analysis (P = .011, OR = 2.818), and EBL was the risk factor through a multivariable analysis (P = .016, OR = 1.002)
We believe that the addition of epinephrine to irrigation saline has hemodynamic protective effects in patients who underwent endoscopic lumbar surgery.
Two-team-approached free flap reconstruction for plantar malignant melanoma: An observational (STROBE-compliant) trial
Authors: Kim Jun Hyeok , Lee Chae Rim , Kwon Hyo Jeong , Oh Deuk Young , Jun Young-Joon , Rhie Jong Won , Moon Suk-Ho 
Published: August 2022

Reconstructive treatments of heel defects usually involve regional flap techniques such as medial plantar flap procedures due to the limited availability of adjacent soft tissues. Although free flaps have advantages in terms of function and aesthetics, they remain challenging due to the longer operation time required than for regional flaps. Thus, we introduce an appropriate 2-team surgical protocol to reconstruct plantar defects after wide excision of malignant melanoma using free flap coverage.
From 2015 to 2020, a retrospective study was performed including 21 patients who underwent free flap surgeries to reconstruct defects due to plantar malignant melanoma. Lymphoscintigraphy was performed to localize sentinel lymph nodes, and the procedure was carried out by 2 teams working together, a tumor-ablative team and a reconstructive team. The present study is adhered to the STROBE guidelines for cohort studies.
The average operation time was 241.4 minutes and was not significantly different even in cases with inguinal dissection (P value: 0.641). All flaps survived after 2 cases of venous insufficiency and 1 case of hematoma were resolved by immediate revision surgery.
The 2-team approach to surgically reconstruct heel defects after wide excision of malignant melanoma using free flap coverage offers favorable results and lower morbidity than regional flap approaches.
Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
Authors: Matsuo Takuji , Tashiro Haruko , Shirasaki Ryosuke , Sumiyoshi Ritsu , Yamamoto Tadashi , Saito Sumiko , Matsumoto Kensuke , Ooi Jun , Shirafuji Naoki 
Published: August 2022

We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24).
We retrospectively analyzed 46 patients with FL admitted to Teikyo University Hospital and treated with chemo-immunotherapy between May 2009 and July 2019. Physical characteristics, blood parameters, and markers or scores for consumptive/inflammatory and nutritional conditions were used as variables.
Nine parameters correlated with poor overall survival (OS) in univariate analysis: An Eastern Cooperative Oncology Group (ECOG) scale performance status (PS) ≥2, five or more involved nodal sites, positive bone marrow (BM) involvement, a serum albumin level <3.5 g/dL, CRP >0.5 mg/dL, lactate dehydrogenase (LD) higher than the upper normal limit (UNL), high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, modified Glasgow prognostic score of 1–2, and the geriatric nutritional risk index <82. In multivariate analysis, ECOG PS ≥2, positive BM involvement, and a serum HDL-C level <40 mg/dL remained significant for poor progression-free survival. One-year OS rate after receiving salvage chemotherapy was lower in the POD24 group (50%) and POD24 correlated with ECOG PS ≥2, positive BM involvement, a serum lactate dehydrogenase >UNL, and HDL-C <40 mg/dL by Fisher’s exact test.
These results indicate that low serum HDL-C levels appear to be important for predicting the risk of POD24 and the worse prognosis of FL.
The role of electronic medical records in improving health care quality: A quasi-experimental study
Authors: Ibrahim Ariff Azfarahim , Ahmad Zamzuri Mohd ‘Ammar Ihsan , Ismail Rosnah , Ariffin Ahmad Husni , Ismail Aniza , Muhamad Hasani Muhamad Hazizi , Abdul Manaf Mohd Rizal 
Published: August 2022

The Teleprimary Care—Oral Health Clinical Information System (TPC-OHCIS) is an updated electronic medical record (EMR) that has been applied in Malaysian primary healthcare. Recognizing the level of patient satisfaction following EMR implementation is crucial for assessing the performance of health care services. Hence, the main objective of this study was to compare the level of patient satisfaction between EMR-based clinics and paper-based clinics.
The study was a quasi-experimental design that used a control group and was conducted among patients in 14 public primary healthcare facilities in the Seremban district of Malaysia from May 10, to June 30, 2021. Patient satisfaction was assessed using the validated Short-Form Patient Satisfaction Questionnaire, which consisted of 7 subscales. All data were analyzed using the IBM Statistical Package for Social Sciences version 21.
A total of 321 patients consented to participate in this study, and 48.9% of them were from EMR clinics. The mean score for the communication subscale was the highest at 4.08 and 3.96 at EMR-adopted clinics and paper-based record clinics. There were significant differences in general satisfaction and communication subscales, with higher patient satisfaction found in clinics using EMR.
With the utilization of EMR, patient satisfaction and communication in delivering healthcare services have improved.
Pediatric medial humeral epicondyle fracture in children: Are biodegradable pins with tension band absorbable sutures efficient?
Authors: Kassai Tamás , Varga Marcell , Józsa Gergő 
Published: August 2022

Medial humeral epicondyle fractures account for 10% to 20% of elbow injuries in children. We hypothesized that in the fixation of medial humeral epicondyle fractures, safety and efficiency of bioabsorbable poly(l-lactide-co-glycolic acid) implant are comparable to traditional metallic and other novel approaches.
A retrospective cohort study was performed between 2016 and 2019, analyzing 24 children who had medial humeral epicondyle fractures. Every fracture was stabilized with biodegradable poly(l-lactide-co-glycolic acid) implants (Bioretec® ActivaPin®) and tension band polydioxanone sutures. Indications for surgery included closed fractures with >1 cm dislocation and incarcerated fractures. Postoperatively, the degree of anatomic reduction and the presence or absence of nonunion or fragmentation were confirmed with X-rays. In this clinical study, we evaluated the operation time, age, and gender distribution.
The mean age at the time of injury was 12.3 (8–16 years). In the fourth week, every patient’s X-ray showed callus formation, and the range of motion of the elbow after 6 months of the operation was almost complete in all children. Transient ulnar nerve palsy was developed in 1 patient, which was spontaneously resolved in the fourth postoperative month. No other complications were observed during the average follow-up period of 34 months (16–60 months).
Bioabsorbable pins with absorbable sutures are a good alternative treatment of medial epicondyle humeral fracture. No permanent complications were noted while using this technique. We suggest this method because it does not require a secondary (metal removal) operation.
Early diagnosis by antigen test kit and early treatment by antiviral therapy: An ambulatory management strategy during COVID-19 crisis in Thailand
Authors: Sayabovorn Naruemit , Phisalprapa Pochamana , Srivanichakorn Weerachai , Washirasaksiri Chaiwat , Auesomwang Chonticha , Sitasuwan Tullaya , Tinmanee Rungsima , Chayakulkeeree Methee , Phoompoung Pakpoom , Mayurasakorn Korapat , Sookrung Nitat , Tungtrongchitr Anchalee , Wanitphakdeedecha Rungsima , Muangman Saipin , Senawong Sansnee , Tangjittipokin Watip , Sanpawitayakul Gornmigar , Woradetsittichai Diana , Nimitpunya Pongpol , Kositamongkol Chayanis , Nopmaneejumruslers Cherdchai , Vamvanij Visit , Chaisathaphol Thanet 
Published: August 2022

This study aimed to assess the clinical characteristics of patients who registered at the Siriraj Favipiravir Clinic and to share our experiences in this comparatively unique clinical setting.
This retrospective study included patients who registered at the Siriraj Favipiravir Clinic during August 11, 2021 to September 14, 2021. Included adult patients were those with severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) infection confirmed by antigen test kit (ATK) or real-time reverse transcription-polymerase chain reaction, no favipiravir contraindication, no prior COVID-19 treatment, and not receiving care from another medical facility. Demographic data and outcomes were collected and analyzed.
Of the 1168 patients (mean age: 44.8 ± 16.4 years, 55.7% female) who registered at the clinic, 117 (10%) did not meet the treatment criteria, and 141 (12%) patients did not pick up their medication. One-third of patients had at least 1 symptom that indicated severe disease. Higher proportion of unvaccinated status (56.7% vs 47.5%, P = .005), higher proportion of persons with risk factors for disease progression (37.7% vs 31.3%, P = .028), and longer duration between the date of clinic registration and the date of positive diagnostic test (3 vs 2 days, P = .004) were significantly more commonly observed in the severe disease group compared to the nonsevere disease group. The duration between symptom onset and the date of clinic registration was significantly longer in the real-time reverse transcription-polymerase chain reaction group than in the ATK group (6 vs 4 days, P < .001). Most patients (90.0%) had completed favipiravir treatment regimen. The improvement and mortality rates were 86.7% and 1.2%, respectively.
COVID-19 severity is associated with vaccination status, baseline risk factors, and timing between disease detection and treatment. The use of ATK influences patients to seek treatment significantly earlier in ambulatory setting. Our early diagnosis and antiviral treatment strategy yielded favorable results in an outpatient setting during a COVID-19 outbreak in Thailand.
Antibiotic Prescribing Patterns for Pediatric Urgent Care Clinicians
Authors: Blanco Maria Victoria , Hamdy Rana F. , Liu Cindy M. , Jones Heather , Montalbano Amanda , Nedved Amanda 
Published: August 2022

Objective
Previous studies have reported high rates of inappropriate antibiotic prescriptions in urgent care (UC). Specific prescribing patterns for the most common diagnoses are not known. The aim of the study is to determine the diagnoses for which antibiotics are prescribed in pediatric UC settings.

Methods
We recruited pediatric UC providers via email to participate in a national multisite quality improvement study. Participants completed a survey on 10 consecutive encounters in which an antibiotic was given between March and May 2018. Encounters in which only topical antibiotics were prescribed were excluded. We categorized the encounters into 3 previously established tiers to determine appropriateness of antibiotic use. The tiers represent a descending order for antibiotic need based on diagnoses, with the first tier representing diagnoses almost always requiring antibiotics and the third tier representing diagnoses when an antibiotic is almost never required. We reported the diagnoses and frequency of antibiotic prescription within each tier.

Results
The 157 providers from 20 institutions submitted a total of 2809 encounters. We excluded 339 encounters in which only topical antibiotics were prescribed. Most diagnoses fell into the tier 2 category (85.81%), with only 9.12% in tier 1 and 5.06% in tier 3. The most common diagnoses reported were acute otitis media (48.96%), pharyngitis (25.09%), and skin and soft tissue infections (7.29%).

Conclusions
In this sample of pediatric UC encounters, only 5% of diagnoses receiving antibiotic prescriptions were made up of tier 3 diagnoses, determined to almost never require antibiotics. While viral respiratory infections have been reported to frequently be treated with antibiotics in general UC centers, our study of pediatric UC centers showed that this was infrequent. However, otitis media with effusion and otalgia should be further investigated. With most antibiotic prescriptions being tier 2 diagnoses, pediatric UC providers can use evidence-based prescribing practices, shared decision making, and contingency plans to reduce unnecessary antibiotic exposure.
Chronic musculoskeletal pain: traps and pitfalls in classification and management of a major global disease burden
Authors: Treede Rolf-Detlef 
Published: August 2022

Abstract
Mary-Ann Fitzcharles et al. propose to introduce “regional fibromyalgia” as a new diagnosis. This commentary summarizes why this term is misleading but nonetheless the article may pave the way towards useful concepts for myofascial pains.
Protracted Postpartum Urinary Retention: Incidence, Risk Factors, and Natural History of a Rare Postpartum Urinary Retention Subtype
Authors: Hickman Lisa C. , Yao Meng , Propst Katie 
Published: August 2022

Importance
Postpartum urinary retention (PUR) is a multifactorial condition that requires a high degree of clinical suspicion for timely diagnosis and proper intervention.

Objectives
The aims of the study are to describe PUR incidence and to compare natural history, obstetric characteristics, and associated risk factors for protracted PUR (extending ≥3 days postpartum) versus PUR.

Study Design
This is a retrospective cross-sectional study of women who underwent an obstetric delivery over 24 months at an academic institution. International Classification of Diseases, Tenth Revision, codes were used to identify PUR. Patient characteristics, obstetric delivery data, and peripartum care surrounding delivery were collected. A P value of 0.05 or less was significant.

Results
Between January 1, 2018, and December 31, 2019, there were 23,844 deliveries (vaginal and cesarean section) and 77 patients (0.32%) experienced PUR. Within this group, 12 (0.05%) experienced protracted PUR. Patients with protracted PUR had a significantly later postpartum diagnosis day (median 1 [interquartile range, 1–2] vs 1 [0–1], P = 0.004), longer time to retention onset (22.0 [10.7–37.0] vs 10.7 [7.9–19.4] hours, P = 0.03), and greater retention duration (12.5 [5.5–17.0] vs 1.0 [0.0–1.0] days, P < 0.001) compared with those with PUR. There were no significant differences in patient or delivery characteristics for those delivering vaginally between the groups.

Conclusions
Protracted PUR is rare, occurring in 0.05% of deliveries. Women with protracted PUR were more likely to have a greater onset time, later diagnosis date, and longer retention duration, out to 47 days, compared with women with PUR resolution before postpartum day 3.
The Elbert range of magnetostrophic convection. I. Linear theory
Authors: Horn Susanne , Aurnou Jonathan M. 
Published: August 2022

In magnetostrophic rotating magnetoconvection, a fluid layer heated from below and cooled from above is equidominantly influenced by the Lorentz and the Coriolis forces. Strong rotation and magnetism each act separately to suppress thermal convective instability. However, when they act in concert and are near in strength, convective onset occurs at less extreme Rayleigh numbers (

R
a

, thermal forcing) in the form of a stationary, large-scale, inertia-less, inviscid magnetostrophic mode. Estimates suggest that planetary interiors are in magnetostrophic balance, fostering the idea that magnetostrophic flow optimizes dynamo generation. However, it is unclear if such a mono-modal theory is realistic in turbulent geophysical settings. Donna Elbert first discovered that there is a range of Ekman (

E
k

, rotation) and Chandrasekhar (

C
h

, magnetism) numbers, in which stationary large-scale magnetostrophic and small-scale geostrophic modes coexist. We extend her work by differentiating five regimes of linear stationary rotating magnetoconvection and by deriving asymptotic solutions for the critical wavenumbers and Rayleigh numbers. Coexistence is permitted if

E
k
<
16

/

(
27
π
)

2

and

C
h
≥
27

π
2

. The most geophysically relevant regime,
the Elbert range
, is bounded by the Elsasser numbers

4
3

(

4
4

π
2

E
k
)

1

/

3

≤
Λ
≤

1
2

(

3
4

π
2

E
k
)

−
1

/

3

. Laboratory and Earth’s core predictions both exhibit stationary, oscillatory, and wall-attached multi-modality within the Elbert range.
Saturation-scale functional evidence supports clinical variant interpretation in Lynch Syndrome
Authors: Scott Anthony , Hernandez Felicia , Chamberlin Adam , Smith Cathy , Karam Rachid , Kitzman Jacob O. 
Published: August 2022

AbstractLynch Syndrome (LS) is a cancer predisposition syndrome affecting more than 1 in every 300 individuals worldwide. Clinical genetic testing for LS can be life-saving but is complicated by the heavy burden of variants of uncertain significance (VUS), especially missense changes. To address this challenge, we leveraged a multiplex analysis of variant effect (MAVE) map covering >94% of the 17,746 possible missense variants in the key LS geneMSH2. Here, to establish the clinical validity of these functional data, and to demonstrate their utility in large-scale variant reclassification, we overlaid them on clinical databases comprising >15,000 individuals with an MMR gene variant uncovered during clinical genetic testing. Our functional measurements agreed with the clinical interpretation for every one of 47 control variants with available classifications, satisfying accepted thresholds for ‘strong’ evidence for or against pathogenicity. We then used these scores to attempt reclassification for 682 unique missense VUS, among which 34 (5.0%) scored as deleterious in our function map, in line with previously published rates among other cancer predisposition genes. Consistent with their pathogenicity, functionally abnormal missense variants were associated with significantly elevated risk for LS-related cancers. Combining functional data and other lines of evidence, ten variants were reclassified as pathogenic/likely pathogenic, and 497 could be moved to benign/likely benign. Finally, we applied these functional scores to paired tumor-normal genetic tests, and identified a subset of patients with biallelic somatic loss of function, reflecting a sporadic Lynch-like Syndrome with distinct implications for treatment and relatives’ risk. This study demonstrates how high-throughput functional assays can empower scalable VUS resolution and prospectively generate strong evidence for variant classification.
Perceived usefulness of simulation learning in hospitality education
Authors: Price-Howard Lisa Kate , Lewis Heather 
Published: August 2022

PurposeThe purpose of this study was to analyze the effectiveness of simulation learning techniques within both face-to-face and online courses. The specific objective for this study was to answer two questions: (1) What are the specific benefits the simulation learning component adds to the course(s)? (2) How do students perceive the usefulness of the simulation learning component to their prepared readiness to enter the industry?Design/methodology/approachAn open-ended survey was administered at the end of the course to conduct a content analysis of student perspectives of the incorporation of cloud-based, educational simulation learning into educational courses. A discussion of the students' perspective of the SIM labs benefits, ease of use and perceived usefulness of this trending learning component has been reviewed, along with the comparison of the online and face-to-face viewpoints.FindingsSome of the identified successes were the ability to collaborate between online and face-to-face classes. Another was the ability to incorporate the application and decision-making components of the textbook into their virtual position of the simulation (SIM) learning lab from an owner's/general manager's perspective. Finally, the SIM labs provided the instructor with a measurable tool to have students compete in a healthy environment.Originality/valueValuable insights were gained into the student's perspective and helped in needed adjustments to better utilize this type of active learning. By studying a specific simulation learning component of this type of electronic learning (e-learning,) valuable contextual explanations to support the other types of active learning techniques mentioned above can be gained.