bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communicating Effectively with Limited English Proficiency Patients: Incorporating Training on Working with Medical Interpreters in the Undergraduate Medical Curriculum
Authors: Wrench Algevis , Fine Lauren , Griffin Daniel P 
Published: October 2022

Abstract
Background: As the number of patients with limited English proficiency (LEP) grows in the United States, medical trainees must be competent to provide care to LEP patients with the use of professional medical interpreters (MIs). Since little time in undergraduate medical education (UME) is devoted to this competency, we developed an educational workshop on effective communication with professional MIs and Spanish-speaking LEP patients.
Methods:In the winter semester of 2022, a two-hour required workshop was implemented with first-year medical students at Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine. This featured four educational strategies: 1) Facilitator-led instructional simulation activity, 2) Interactive didactic via PowerPoint, 3) Small group clinical case discussion, and 4) Large group MI simulation activity. Participant volunteers completed an anonymous, pre - and post-workshop evaluation and a self-assessment to determine post-intervention readiness to interact with MIs.
Results:Of the 51 participants, 43 (84%) completed the pre- and post-workshop evaluations. Approximately 83% reported “little to no” or “limited” Spanish language fluency. Participants reported a statistically significant (p<0.05) increase in their confidence to explain the importance of using MIs to improve LEP patient care, and to demonstrate both respect for the individual and cultural humility when using MIs. The self-assessment showed an increase in the average score for all questions tested. Ninety-eight percent of the participants strongly agreed or agreed that the workshop met its objectives. Thematic analysis of qualitative feedback centered around three major themes: MI need, MI practice, and medical Spanish knowledge.
Conclusions:Our curricular intervention was successful in increasing self-reported measures of skills and best practices on how to communicate effectively with Spanish-speaking LEP patients with the use of MIs. Implementation of MI training programs in UME can be a successful strategy to prepare trainees to provide care for the growing LEP population.
How does green finance affect cleaner industrial production and end-of-pipe treatment performance? Evidence from China
Authors: Fang Yong , Shao Zhenquan 
Published: October 2022

Abstract
Effectively identifying the role and mechanism of green finance in environmental governance provides an important guarantee that green finance serves the ecological environment. Based on the panel data of 30 provinces in China from 2001 to 2015, this paper explores the impact of green finance on cleaner industrial production and end-of-pipe treatment and further reveals the mediating effect of industrial structure optimization and the moderating effect of environmental regulation. The results show that (1) China's cleaner industrial production performance, end-of-pipe treatment performance and systematic governance performance show a clear upwards trend, and the end-of-pipe treatment performance was generally better than the cleaner production performance. (2) Green finance promotes cleaner production performance but inhibits end-of-pipe treatment performance. The optimization of industrial structure plays a partial intermediary role in the impact of green finance on cleaner production and end-of-pipe treatment. (3) Both "market-incentive" and "command-and-control" environmental regulations weaken the positive impact of green finance on cleaner production; "market-incentive" environmental regulation alleviates the negative impact of green finance on end-of-pipe treatment, while the moderating effect of "command-and-control" environmental regulation on end-of-pipe treatment is not significant.
Niche modelling and molecular phylogenetics unravel the invasion biology and worldwide colonization of three species of the freshwater planarian genus Girardia (Platyhelminthes, Tricladida)
Authors: Benítez-Álvarez Lisandra , Leria Laia , Sluys Ronald , Leal-Zanchet Ana María , Riutort Marta 
Published: October 2022

Abstract

Several species of the freshwater planarian genus Girardia have been introduced into freshwater ecosystems all over the world, but little is known about the actual number of species involved and about possible detrimental effects on autochthonous ecosystems. In the present study, we used molecular phylogenetics and niche modelling under present and future climatic scenarios to examine the human-induced dispersal and spread of alien species of Girardia from their original areas of distribution in the Americas to other parts of the globe. Our results corroborate that the Girardia populations spreading worldwide belong to three species of North American origin: G. dorotocephala, G. sinensis, and G. tigrina. Our study emphasizes that G. sinensis is native to North America, from where it colonised China, as well as Europe, Africa and Australia. It also shows that G. dorotocephala has a broader range of localities where it was introduced than previously known, including Europe and Brazil. Niche modelling revealed that the three colonising species have a broad range of potential distribution in extensive regions of the Northern Hemisphere; regardless of the climatic scenario, in the future, their distributional range will increase towards northern Europe, without diminishing the high suitability of regions in the south. Their environmental requirements, being generalists with high suitability for human-modified habitats, explain their successful colonization. In the Iberian Peninsula, introduced G. tigrina and G. sinensis have extensive areas of high suitability, overlapping with the more limited suitable areas of autochthonous freshwater planarians, pointing to potential detrimental effects of Girardia invaders.
Rice endosperm-derived antidepressant-like peptide (REAP): An orally active novel tridecapeptide derived from rice protein
Authors: Ohinata Kousaku , Asakura Saho , Kaneko Kentaro , Kawano Kohei , Shobako Maiko , Jo Shinto , Sato Masaru , Kurabayashi Atsushi , Suzuki Hideyuki , Ito Akira , Higuchi Yuki , Nakayama Ryoko , Takahashi Hajime 
Published: October 2022

Abstract
It is ideal to ingest bioactive substances from daily foods to stay healthy. Rice is the staple food for almost half of the human population. We found that an orally administered enzymatic digest of rice endosperm protein exhibits antidepressant-like effects in the tail suspension test (TST) using mice. We performed a comprehensive peptide analysis of the digest using liquid chromatography-tandem mass spectrometry, and the tridecapeptide QQFLPEGQSQSQK emerged as a candidate of the antidepressant-like peptide. Oral administration of the chemosynthetic peptide exhibited antidepressant-like effects at a low dose comparable to known drugs in the TST. This also exhibited anti-depressant-like effect in the forced swim test. We named it rice endosperm-derived antidepressant-like peptide (REAP). Intriguingly, intraperitoneal administration had no effect. Orally administered REAP(8–13) but not REAP(1–7) exhibited antidepressant-like activity, suggesting that the C-terminal structure is important for the antidepressant-like effect. We confirmed the presence of REAP, corresponding to rice glutelin type B4(130–142) and B5(130–142), in the digest. The effects of REAP were blocked by either intraperitoneal or intracerebroventricular administration of a dopamine D1 antagonist; however, REAP had no affinity for the receptor. These results suggest that it exerts its antidepressant-like activity through promotion of endogenous dopamine release and activation of central D1 receptors. REAP-induced antidepressant-like effect was at least in part blocked by vagotomy, implying the gut-brain communication is associated with REAP’s effect. Taken together, oral administration of a novel tridecapeptide exhibited antidepressant-like effects via the dopamine D1 system. This is the first report of a rice-derived peptide that exhibits antidepressant-like effects.
A negative stiffness inertial nonlinear energy sink
Authors: Zhang Zhen , Gao Yuan , Zhang Ye-Wei , Fang Bo 
Published: October 2022

Abstract
In this paper, a novel negative stiffness inertial nonlinear energy sink (NSI-NES) is proposed. The main structure is simulated as a single-degree-of-freedom linear oscillator. Newton's second law is applied to derive the kinematic equations of the coupled system. Based on the Runge–Kutta numerical solution, the complex dynamical behaviors of the system coupled with the NSI-NES are explored. Moreover, the quasiperiodic solution exhibited a strongly modulated response (SMR). The steady-state response of the system is obtained using the Runge–Kutta and harmonic balance methods and is cross-corroborated. Compared with the inertial nonlinear energy sink (I-NES) and the positive stiffness inertial nonlinear energy sink (PSI-NES), the damping effects of the NSI-NES are highlighted based on various excitations. The results show that the NSI-NES has a damping effect of up to 90%. In addition, the effect of the NSI-NES parameters on the damping effect is discussed. In general, the negative stiffness element can significantly improve NES performance. Therefore, this study promotes the application of negative stiffness and inerter in engineering.
Screening for climate adaptative loci using seascape genomics resolves phenotypic variation in heat tolerance of the coral Acropora millepora.
Authors: DENIS Hugo , Selmoni Oliver , Gossuin Hugues , Jauffrais Thierry , Lecellier Gaël , Berteaux-Lecellier Véronique 
Published: October 2022

Abstract
One of the main challenges in coral reef conservation and restoration is the identification of coral populations resilient under global warming. Seascape genomics is a powerful tool to uncover genetic markers potentially involved in heat tolerance among large populations without prior information on phenotypes. Here, we aimed to confirm the role of several candidate heat associated loci identified using this method in driving the phenotypic response of Acropora millepora from New Caledonia to thermal stress. We subjected 7 colonies to a long-term ex-situ heat stress assay (4°C above the Maximum Monthly Mean) and investigated their physiological response along with their Symbiodiniaceae communities and genotypes. Despite having similar thermal histories and associated symbionts, these conspecific individuals differed greatly in their tolerance to heat stress. More importantly, the clustering of individuals based on their alleles at the candidate loci was able to resolve most of the phenotypic variation in heat tolerance. Colonies harboring a higher proportion of beneficial alleles sustained on average lower mortality, higher Symbiodiniaceae/chlorophyll concentrations and photosynthetic efficiency under prolonged heat stress. Together these results support the relevance of seascape genomics to reveal candidate loci for heat adaptation in corals and develop predictive models of heat tolerance.
The use of blockchain as an efficient medical record-keeping system in s health care
Authors: Ngutshane Dimakatso , Magida Ayanda 
Published: October 2022

Abstract
Background
Blockchain technology has sparked widespread interest, with applications ranging from data management to financial services and the healthcare business. The use of blockchain technologies to deliver safe and secure health data management has sparked much attention. Blockchain is transforming traditional healthcare methods into a more dependable means of treatment and diagnosis by providing secure and safe data sharing. Blockchain could be a technology that, in the future, helps with tailored, genuine, and secure healthcare by combining all of a patient's real-time clinical data and organising it in an up-to-date secure healthcare setting. This study explores the feasibility of adopting blockchain for effective patient medical records management in South Africa’s healthcare industry.
Methods
Qualitative interviews were conducted with six medical systems analysis experts and probed deeper for their viewpoints and a greater understanding of the field. Finally, a thematic analysis was conducted under the pretext of research, in which the overlaps of various specialists were examined.
Findings
Three themes emerged from the findings: misconceptions about blockchain technology in healthcare, Legacy Filing Systems, and the blockchain's benefits. All participants view blockchain as providing transparency, traceability, and immutability, decreasing risk. Hospitals and healthcare professionals must first demonstrate a willingness to adopt and accept blockchain technology and resolve any obstacles.
Conclusion
The findings suggest blockchain could be a good solution for managing patient medical records. However, the South African healthcare sector is not ready to utilise blockchain, and education is required.
Citrus Pulp in Broilers Feeding (1-42 Days)
Authors: Diaz-Vargas Mayra , Murakami Alice Eiko , Zanetti Leonardo Henrique , Lipori Humberto , Sakamoto Márcia Izumi , Nascimento Guilherme 
Published: October 2022

Abstract
The aim of this study to determine the chemical composition, the metabolizable energy, and digestibility of citrus pulp; furthermore, evaluate the effect of using this product on performance, carcass yield, and blood parameters of broilers from 1 to 42 days of age. In the first experiment, it was using a total of 108 21-days-old male Cobb 500 birds weighing 926 g ± 50g was distributed in a completely randomized design with three treatments (basal diet and basal diet + 10 or 20% of testing feed), and six replicates of six birds each. In the second experiment, it was using a total of 966 1-day-old Cobb 500 male broiler chicks was distributed in a completely randomized design with six treatments (0, 2, 4, 6, 8 and 10% inclusion of citrus pulp) and seven replicates of 23 birds each. The citrus pulp presented 1311 kcal of AME/kg DM, 4.62% crude protein, 30.85% neutral detergent fiber, 36.93% acid detergent fiber and 23.45% pectin. The citrus pulp can be used up to 10.0% of inclusion in broiler diets in the period from 1 to 42 days old, with no damage to performance, carcass yield, blood parameters and with better economic indices.
Combined Metabolic Activators Improve Cognitive Functions in Alzheimer’s Disease Patients: A Randomised, Double-Blinded, Placebo-Controlled Phase-II Trial
Authors: YULUG BURAK , ALTAY OZLEM , LI XIANGYU , HANOGLU LUTFU , CANKAYA SEYDA , LAM SIMON , VELIOGLU HALIL AZIZ , YANG HONG , COSKUN EBRU , IDIL EZGI , NOGAYLAR RAHIM , OZSIMSEK AHMET , BAYRAM CEMIL , BOLAT ISMAIL , ONER SENA , TOZLU OZLEM OZDEMIR , ARSLAN MEHMET ENES , HACIMUFTUOGLU AHMET , YILDIRIM SERKAN , ARIF MUHAMMAD , SHOAIE SAEED , ZHANG CHENG , NIELSEN JENS , TURKEZ HASAN , BOREN JAN , UHLEN MATHIAS , Mardinoglu Adil 
Published: October 2022

Abstract

Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administrated Combined Metabolic Activators (CMA) to the AD rat model and observed that administration of CMA activated the mitochondrial functions and eventually improved the AD-associated histological parameters in the animals. CMA consists of NAD + and glutathione precursors and includes L-serine, nicotinamide riboside, N-acetyl-L-cysteine, and L-carnitine tartrate. Methods Here, we designed a randomised, double-blinded, placebo-controlled phase-II trial and studied the effect of CMA administration on the global metabolism of AD patients. The primary endpoint was on the difference in cognitive and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. We also performed a comprehensive human plasma metabolome and proteome analysis. Results Based on our analysis, we showed a significant decrease of ADAS-Cog scores on Day 84 vs Day 0 (p = 0.00001, 29% improvement) in the CMA group. Moreover, there was a significant enhancement (p = 0.0073) in ADAS-Cog scores between CMA and placebo groups in patients with higher ADAS-Cog scores. Improved cognitive functions were endorsed with relevant hippocampal volumes and cortical thickness alterations. Moreover, the plasma levels of proteins and metabolites associated with NAD + and glutathione metabolism are significantly improved after treatment. Conclusion In conclusion, our results show that treating AD patients with CMA leads to enhanced cognitive functions associated with the improved metabolome, proteome and structural neuroimaging parameters, suggesting a role for such a therapeutic regimen in treating patients, especially with severe AD. Trial registration: ClinicalTrials.gov NCT04044131 Registered 17 July 2019, https://clinicaltrials.gov/ct2/show/NCT04044131
Analysis of resident mental health and its influencing factors: a single-centre cross-sectional study
Authors: Luo Jiahui , Yang Lingli , Zhang Changlin , Zhang Huaxia , Yu Jiale , Bao Lingbo , Liu Fang 
Published: October 2022

Abstract
Background: With a high rate of positive psychological problem detections and as one of the main reasons why residents are unable to complete the required amount of training, the mental health of residents has attracted more attention in recent years. This study aims to comprehend the psychological well-being of Chinese residents and investigate the factors affecting their mental health.
Methods: A self-administered questionnaire containing the General Information Questionnaire and the Depression-Anxiety-Stress Scale (DASS-21) was used in a cross-sectional study at the First Affiliated Hospital of Kunming Medical University to survey residents and compare differences in the mental health status of residents with various characteristics. Univariate analyses and logistic regression analysis were performed to identify said factors.
Results: Out of the 386 valid questionnaires that were collected, univariate analyses showed that daily sleep time, weekly frequency movement, income, training department, gender impact on the resident’s mental health(P<0.05). Logistic regression analysis showed that sleeping less than 6 hours, internships in other departments, and male trainees are associated with the level of mental health.
Conclusion: These results imply that residents' mental health issues may be closely related to residency training characteristics and the training environment, or that routine psychological therapy for important targets will improve residents' mental health and guarantee successful training completion.
Uremic toxins, inflammation biomarkers and hepcidin in older CKD patients switched from high flux HD to OL-HDF
Authors: Fanchini Vanessa , Morales Armando , Silva Luana Cristina Almeida , Gonçalves Thiago José Martins , Kussi Fernanda , Nakao Lia Sumie , Elias Rosilene Motta , Dalboni Maria Aparecida 
Published: October 2022

Abstract
Anemia is a common complication that is associated with mortality in patients with chronic kidney disease (CKD). Despite the use of erythropoiesis-stimulating agents (ESAs) to correct anemia, some patients are hyporesponsive due to the state of micro-inflammation caused by uremic toxins and hepcidin, a hormone that plays a central role in iron homeostasis. Hemodiafiltration (OL-HDF) has been associated with better clearance of uremic toxins, such as indoxyl sulfate (IS), p-cresyl sulfate (PCS) and indole acetic ascorbic (IAA) than conventional hemodialysis (HD). The aim of the study was to evaluate the effect of OL-HDF treatment on the concentration of IS, PCS, IAA, hepcidin and inflammatory biomarkers in CKD patients. Thirty-one patients (> 65 years old) incident in OL-HDF were followed for 6 months. IS, PCS, IAA, biochemical parameters, hepcidin and inflammatory cytokines were evaluated at baseline and after 6 months. We observed a significant decrease in IS and CRP plasma concentration, an increase in hemoglobin and hematocrit after 6 months of treatment with OL-HDF (p <0.05). This prospective observational study demonstrated that OL-HDF was capable to reduce IS and CRP in older patients. Whether this reduction may have an impact on clinical outcomes must be investigated in a future study.
Polyglycerol-amine Covered Nanosheets Target Cell-free DNA to Attenuate Acute Kidney Injury
Authors: Wu Kefei , Lu Xiaohui , Li Yi , Wang Yating , Liu Ming , Li Hongyu , Li Huiyan , Chen Wei , Liu Qinghua , Zhou Yi , Tu Zhaoxu , Mao Haiping 
Published: October 2022

Abstract
Increased levels of circulating cell-free DNA (cfDNA) are associated with poor clinical outcomes in patients with acute kidney injury (AKI). Scavenging cfDNA by nanomaterials has been regarded as a promising remedy for cfDNA-associated diseases. Nevertheless, the nanomaterials-based cfDNA scavenging tactic has not yet been reported in AKI treatment. Herein, polyglycerol-amine (PGA) covered MoS2 nanosheet with medium size (M-PGA-M) was erected to bind negatively charged cfDNA for AKI treatment. M-PGA-M exhibited excellent cfDNA scavenging efficacy and low cytotoxicity, which effectively reduced serum cfDNA levels, dominantly accumulated in kidney to inhibit neutrophil extracellular trap formation and inflammation, thereby alleviating LPS-induced AKI in mice. The renoprotective effects of M-PGA-M were superior to corresponding polymer PGA attributed to its unique two-dimensional nanostructure. Further, M-PGA-M showed to decrease serum cfDNA from AKI patients. Collectively, M-PGA-M could serve as a potent cfDNA scavenger, suggesting its potential application in treating AKI and other cfDNA-associated diseases. Teaser Scavenging cell-free DNA (cfDNA) with polyglycerol-amine (PGA)-covered MoS2 nanosheets may represent a novel treatment for AKI.