bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of long-term prognosis based on measurements achieved after 9-week hybrid telerehabilitation in heart failure patients – a subanalyis of the TELEREH-HF RCT
Authors: Piotrowicz E , Pencina M , Kowalik I , Orzechowski P , Banach M , Glowczynska R , Zareba W , Opolski G , Szalewska D , Pluta S , Kalarus Z , Irzmanski R , Piotrowicz R 
Published: October 2022

Abstract

Background
Predicting prognosis in heart failure (HF) is of major importance.
The purpose of the study was to define predictors influencing long-term cardiovascular mortality or HF hospitalization (“composite outcome”) based on clinical status and measurements obtained after the 9-week hybrid comprehensive telerehabilitation (HCTR) programme.

Methods
This analysis is based on TELEREH-HF multicenter, randomized trial that enrolled 850 HF patients (NYHA I-III; left ventricular ejection fraction [LVEF]≤40%). Patients were randomized 1:1 to 9-week HCTR plus usual care (development sample) or usual care only (validation sample) and followed for 12–24 months for development of the composite.

Results
The predictors of our composite were: non-ischaemic etiology of HF, diabetes, higher serum level of: N-terminal prohormone of brain natriuretic peptide, creatinine, and high-sensitivity C-Reactive Protein; low carbon dioxide output at peak exercise, high minute ventilation and breathing frequency at maximum effort in cardiopulmonary test; increase of delta of average heart rate in 24h-ECG Holter monitoring, lower LVEF and patients' non-adherence to HCTR. The model discrimination C-index=0.795 and decreased to 0.755 on validation (Table 1). The 2-year risk of the composite was 48% in the top tertile versus 5% in the bottom tertile (Figure 1).

Conclusion
Risk factors collected at the end of the 9-week telerehabilitaion period did an excellent job in stratifying patients based on their 2-year risk of the composite outcome. Patients in the top tertile had an almost ten-fold higher risk compared to patients in the bottom tertile. Adherence to treatment but not peakVO2 or quality of life were significantly associated with the outcome.

Funding Acknowledgement
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Centre for Research and Development, Warsaw, Poland
Evaluating systemic immune-inflammation index in patients with implantable cardioverter defibrillator for heart failure with reduced ejection fraction
Authors: Hayiroglu M , Cinar T , Cinier G , Pay L , Yumurtas A C , Tezen O , Eren S , Kolak Z , Cetin T , Cicek V , Tekkesin A I 
Published: October 2022

Abstract

Background
Pro-inflammatory pathways play a serious role in the follow-up of patients with intracardiac defibrillator (ICD) for heart failure reduced with ejection fraction (HFrEF). A newly defined index, which is named as systemic immune-inflammation index (SII), has been recently reported to have prognostic value in patients with cardiovascular disease.

Purpose
The aim of this investigation is to evaluate the value of SII in terms of its association with long-term mortality and appropriate ICD therapy during in 10-year follow-up.

Methods
This retrospective study included 1011 patients with ICD for HFrEF. The study population was divided into two groups according to optimal cut-off value of SII to predict long-term mortality. The long-term prognostic impact of SII on these patients were evaluated in terms of mortality and appropriate ICD therapy.

Results
A receiver operating characteristic curve analyses of systemic immune-inflammation index, platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in long-term mortality and appropriate intracardiac defibrillator therapy for patients intracardiac defibrillator for heart failure reduced with ejection fraction were presented in Figure 1A and 1B respectively. The patients with higher SII had significantly higher long-term mortality and appropriate ICD therapy. After adjustment for all confounding factors, the long-term mortality had 5.1 higher rates at higher SII. (95% CI: 2.9–8.1). The long-term appropriate ICD therapy also had 2.0 higher rates at higher SII (95% CI: 1.4–3.0). Kaplan Meier survival analysis of patients according to the systemic immune-inflammation index was presented in Figure 2.

Conclusion
SII, calculated using neutrophil, platelet, and lymphocyte counts, may be an independent predictive marker for both long-term mortality and appropriate ICD therapy in patients with HFrEF.

Funding Acknowledgement
Type of funding sources: None.
Diabetes may modify the efficacy of primary prevention implantable cardioverter-defibrillators in non-ischemic systolic heart failure: an extended follow-up of the DANISH trial
Authors: N Doi S , Butt J H , Rorth R , Thune J J , Nielsen J C , Haarbo J , Eiskjaer H , Hassager C , Svendsen J H , Hofsten D E , Torp-Pedersen C , Pehrson S , Kristensen S L , Kober L 
Published: October 2022

Abstract

Background
Since patients with both diabetes and heart failure (HF) have a substantially worse prognosis than those with each of these alone, the efficacy of implantable cardioverter defibrillator (ICD) implantation in patients with systolic HF may be modified by diabetes status.

Purpose
In this extended follow-up analysis of the Danish Study to Assess the Efficacy of primary prevention of Implantable Cardioverter Defibrillators in Patients with Non-ischemic Systolic Heart failure on Mortality (DANISH), adding four years of additional follow-up, we examined the long-term effects of primary prophylactic ICD implantation, compared with usual clinical care, in patients with non-ischemic systolic HF according to diabetes status.

Methods
In DANISH, 1,116 patients with non-ischemic systolic HF were randomized to receive an ICD (N=556) or usual clinical care (N=550). Outcomes were analyzed according to diabetes status at baseline. The primary outcome was death from any cause. Secondary outcomes were cardiovascular death and sudden cardiovascular death.

Results
Of the 1,116 patients randomized in DANISH, 211 (18.9%) had diabetes at baseline (median age 64 year-old, 159 males, median left ventricular ejection fraction 25%). There was a statistically significant interaction between diabetes and the effect of ICD implantation on death from any cause and cardiovascular death. There was a trend toward a reduction in both outcomes with ICD implantation, compared with usual clinical care; in patients without diabetes (death from any cause, HR 0.81 [95% CI, 0.65–1.01]; cardiovascular death, HR 0.77 [0.59–1.01]), but not in those with diabetes (death from any cause, HR 1.19 [0.81–1.74]; cardiovascular death, HR 1.20 [0.79–1.82]) (P for interaction = 0.04 and 0.04 for death from any cause and cardiovascular death, respectively). Although there was no statistically significant interaction between diabetes and the effect of ICD implantation on sudden cardiovascular death, ICD implantation significantly reduced the rate of sudden cardiovascular death in patients without diabetes (HR 0.51 [0.31–0.85]), but not in those with diabetes (HR 0.91 [0.41–1.99]) (P for interaction = 0.15).

Conclusions
In patients with non-ischemic systolic HF, there was a significant interaction between diabetes and the effect of ICD implantation on death from any cause and cardiovascular death, suggesting that individuals without diabetes may derive greater benefit from ICD implantation.

Funding Acknowledgement
Type of funding sources: None.
Fusion CRT pacing: septal flash significance in super responder patients
Authors: Vacarescu C , Luca C T , Gaita D , Crisan S , Mornos C , Goanta E V , Lazar M A , Ionac I , Arnautu D A , Cozma D 
Published: October 2022

Abstract

Background
LV only CRT pacing is an option that may be considered to maximize response to CRT and at least as an alternative in non-responders to biventricular (BiV) pacing. However, criteria to best titrate therapy on an individual basis are lacking in fusion pacing. On the other hand, septal flash (SF) is a strong predictor of favorable response for patients (pts) with BiV pacing.

Purpose
To analyze the relationship between SF and the response to fusion CRT pacing.

Methods
Consecutive pts with exclusive fusion CRT-P were included. Right atrium/left ventricle leads DDD CRT pacing system were used in all patients. Prospective data were collected at every 6 months follow-up visits: device interrogation, exercise test, echocardiographic parameters. Exercise tests, device reprogramming and medication optimization were performed regular in order to maximize CRT response. Patients were divided in 2 groups: super-responders (SR) and responders (R). SRs were defined those with left ventricular end-systolic volume (LVESV) improvement ≥30% and stable ejection fraction (LVEF) ≥45%.

Results
69 pts with NYHA II–III heart failure and non-ischemic dilated cardiomyopathy were initially included. 5 pts were non responders and excluded (non LBBB, spontaneous QRS &lt;149 ms). Final analyzed group had 64 pts (35 male) aged 60±12 y.o. The mean follow-up was 54±19 months; 22 pts (34%) were SRs. At baseline, SF was found in all SR pts and in 55% of R pts. SF was corrected post CRT in all patients, except one. For this patient (LV lead in a posterior branch of the coronary sinus – CS) the strategy included an upgrade to triple chamber device with a second lead in a lateral branch of the CS and became SR from R. Mitral regurgitation decreased in 38 patients (all SR, 40% R). Interesting, baseline left atrium volume and pulmonary sistolic artery pressure were smaller in SR versus R group, however SF did not corelate with LA volume/diastolic dysfunction.

Conclusions
Septal flash seems to be a strong predictor of super-response in patients with fusion CRT pacing. This finding could improve the selection of candidates for fusion CRT-P, however larger studies are needed to assess SF in this categories of patients.

Funding Acknowledgement
Type of funding sources: None.
Expansion and Neofunctionalization of Actinoporin-like Genes in Mediterranean Mussel (Mytilus galloprovincialis)
Authors: Koritnik Neža , Gerdol Marco , Šolinc Gašper , Švigelj Tomaž , Caserman Simon , Merzel Franci , Holden Ellie , Benesch Justin L P , Trenti Francesco , Guella Graziano , Pallavicini Alberto , Modica Maria Vittoria , Podobnik Marjetka , Anderluh Gregor 
Published: October 2022

Abstract
Pore-forming toxins are an important component of the venom of many animals. Actinoporins are potent cytolysins that were first detected in the venom of sea anemones; however, they are occasionally found in animals other than cnidarians and are expanded in a few predatory gastropods. Here, we report the presence of 27 unique actinoporin-like genes with monophyletic origin in Mytilus galloprovincialis, which we have termed mytiporins. These mytiporins exhibited a remarkable level of molecular diversity and gene presence–absence variation, which warranted further studies aimed at elucidating their functional role. We structurally and functionally characterized mytiporin-1 and found significant differences from the archetypal actinoporin fragaceatoxin C. Mytiporin-1 showed weaker permeabilization activity, no specificity towards sphingomyelin, and weak activity in model lipid systems with negatively charged lipids. In contrast to fragaceatoxin C, which forms octameric pores, functional mytiporin-1 pores on negatively charged lipid membranes were hexameric. Similar hexameric pores were observed for coluporin-26 from Cumia reticulata and a conoporin from Conus andremenezi. This indicates that also other molluscan actinoporin-like proteins differ from fragaceatoxin C. Although the functional role of mytiporins in the context of molluscan physiology remains to be elucidated, the lineage-specific gene family expansion event that characterizes mytiporins indicates that strong selective forces acted on their molecular diversification. Given the tissue distribution of mytiporins, this process may have broadened the taxonomic breadth of their biological targets, which would have important implications for digestive processes or mucosal immunity.
Explicit criteria for exponential stability in mean square of stochastic difference systems with delays
Authors: Trung Hieu Le , Huu anh Ngoc Pham , Bao Tran Thai , Dinh Huy Nguyen 
Published: October 2022

Abstract
By a novel approach, we present some new criteria for the exponential stability in mean square of solutions of non-linear stochastic difference systems with time-varying delays. A discussion of the obtained results is given. Illustrative examples and simulations are provided.
Multilevel quasi-interpolation
Authors: Franz Tino , Wendland Holger 
Published: October 2022

AbstractQuasi-interpolation methods are well-established tools in multivariate approximation. They are efficient as they do not require, in contrast to interpolation, the solution of a linear system. Quasi-interpolations are often first studied on infinite grids. Here, it is usually required that the quasi-interpolation operator reproduces polynomials of a certain degree exactly. This degree corresponds to the approximation order of the quasi-interpolation process. Unfortunately, if a radial, compactly supported kernel is employed for building the quasi-interpolation operator, it is well known that polynomial reproduction is impossible in two or more dimensions. As such operators are numerically appealing and are frequently used in particle methods, we will, in this paper, look at such quasi-interpolation operators that do not reproduce polynomials and show that they lead, when employed in a multilevel scheme, to an efficient and converging approximation method.
The Cost of Resistance to Diamide Insecticide Varies With the Host Plant in Spodoptera frugiperda (Lepidoptera: Noctuidae)
Authors: Oliveira Padovez Fernando Elias , Hideo Kanno Rubens , Zaia Zambon Gustavo , Omoto Celso , Sartori Guidolin Aline 
Published: October 2022

Abstract
Fitness costs associated with insect resistance to insecticides can be exploited to implement resistance management programs. However, most of these studies are restricted to evaluating biological traits on artificial diets. Here, we investigated the fitness cost associated with chlorantraniliprole in Spodoptera frugiperda (J.E. Smith) feeding on corn, soybean, and cotton plants. We used a near-isogenic strain of S. frugiperda resistant to chlorantraniliprole (Iso-RR), a susceptible strain (SS), and heterozygotes strains (H1 and H2) to evaluate several biological and population growth parameters. Larval survival of the Iso-RR strain was on average 90% on corn, 65% on soybean, and 57% on cotton plants. Development time of the larval stage also differed among host plants, Iso-RR strain took on average 14, 17, and 26 days to reach the pupal stage on corn, soybean, and cotton plants respectively. Net reproductive rate, intrinsic rate of population increase, and finite rate of population increase were higher for Iso-RR strain feeding on corn plants than other host plants. The relative fitness, based on the intrinsic rate of population increase, of S. frugiperda resistant strain on corn, soybean, and cotton plants were 1.04, 0.85, and 0.88, respectively. Therefore, no fitness cost was observed for S. frugiperda feeding on corn plants, but a significant fitness cost was observed when this pest fed on soybean and cotton plants. We showed that the food source influences the fitness cost of S. frugiperda resistant to diamide. Such information may help to implement resistance management strategies based on each crop.
Schumpeter Lecture 2022: Job Search in the 21St Century
Authors: Kircher Philipp 
Published: October 2022

Abstract
Formal job search has undergone massive transformations in the last two decades with the move to online platforms. This makes more stages of the job search process observable, and allows researchers to intervene in this market and improve the design of the job search process and the information available in it. This paper showcases studies that illustrate the potential of analyzing online job search data and of intervening in the online job search process. It presents the current insights and some open questions and highlights conditions under which some of the recent interventions are likely to improve market outcomes overall, rather than improving only the outcomes for the treated individuals.
Genocide and Ukraine
Authors: Schabas William A 
Published: October 2022

Abstract
Allegations of genocide have been made on both sides during the armed conflict in Ukraine. This article reviews the claims, concluding that they appear to be inconsistent with the crime of genocide as defined in Article II of the 1948 Convention, as interpreted by the International Court of Justice, the ad hoc tribunals and the International Law Commission. Most of the claims appear to use the term genocide in a rhetorical sense, without serious concern for the legal issues. The available evidence does not permit inferences to be drawn that the punishable acts are committed with genocidal intent, to the exclusion of other reasonable explanations.
Differential Effects on HbA1c Detection by HPLC and Capillary Electrophoresis in Five Types of Hb Variants in China
Authors: Wei Luo , Weifeng Zhang , Zuoliang Dong 
Published: October 2022

Abstract

Objective
Hemoglobin A1c (HbA1c) can be used to evaluate blood glucose control. Its measurement will be affected by many factors, but Hb variation is the most critical factor. This study aimed to explore the types of variants found in routine work and their impact on test results.

Methods
Samples with abnormal HbA1c chromatograms found in routine testing were tested with high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) and then further tested with polymerase chain reaction (PCR) and sequencing.

Results
Five recessive heterozygous mutations were identified after PCR and sequencing. Hb Riccarton-II (a mutation in the HBA2 gene), Hb E, Hb G-Coushatta, Hb G-Taipei, and Hb North Manchester (a mutation in the HbB gene) were identified. All HbA1c values of these variants detected by HLC-723 G8 (HPLC method) were lower than those of Sebia Capillarys 2 FP (C2FP, CE method) with P &lt; .0001.

Conclusion
Five Hb mutations were identified in our routine HbA1c test, and their HPLC detection values were significantly lower than those obtained with the CE method.
A Decade of Surgery Aboard the U.S. Naval Ship COMFORT (T-AH 20)
Authors: Worlton Tamara J , Gunasingha Rathnayaka M K D , Atwood Rex , Johnson Mark , Uber Ian C 
Published: October 2022

ABSTRACT

Introduction
The U.S. Naval Ship COMFORT has performed six humanitarian assistance and disaster relief mission since 2007. This paper describes the surgical volume per surgical specialty for five missions spanning 19 countries.

Materials and Methods
Raw surgical case logs were analyzed for total case volume, total operating days, unanticipated return to operating room, and percentage of pediatric cases (&lt;18 years old) for each country visited.

Results
Total surgical volume for the five missions was 5,142. The countries most frequently visited were Columbia and Haiti with seven and five visits, respectively. General surgery, ophthalmology, and plastic surgery have had consistent volume over time. Orthopedic surgery volume has steadily decreased with the exception of the 2018 mission.

Conclusion
As volume in military treatment facilities declines, alternative sources of surgical volume for military surgeons are being examined. This paper highlights the historical volume which can inform future personnel planning requirements of U.S. Naval Ship COMFORT missions. With the exception of orthopedic surgery, surgical volume has remained consistent over the last decade. For future best practice, historical case data should be used to determine staffing needs on hospital ships and case logs and operating procedures and follow-up protocols should be standardized.
Self-Reported Health Care Avoidance Behavior in U.S. Military Pilots Related to Fear for Loss of Flying Status
Authors: Hoffman William R , Aden James K , Barbera Daniel , Tvaryanas Anthony 
Published: October 2022

ABSTRACT

Introduction
U.S. military pilots are required to meet certain medical standards in order to maintain an active flying status. Military pilots face potential temporary or permanent loss of flying privileges in the setting of a new condition or symptom that does not meet required standards, which could result in negative social and occupational repercussions for the pilot. For this reason, it has been proposed that U.S. military pilots participate in health care avoidance behavior, but little evidence exists to characterize such a trend in this population.

Materials and Methods
We conducted a non-probabilistic Internet survey of the general population of U.S. pilots from November 1, 2019 through August 1, 2021. The current study is a sub-analysis of military pilots.

Results
A total of 4,320 pilots answered the informed consent question, and 264 selected one military pilot type and were included in this sub-analysis. There were 72% of military pilots who reported a history of health care avoidance behavior (n = 190), and no statistical difference was found between age groups, gender, and military pilot types. There were 55.5% of pilots who reported a history of seeking informal medical care (n = 147), 33.7% of pilots who have flown despite a new symptom they felt required medical evaluation, 42.5% of pilots who reported withholding information on aeromedical screening (n = 111), and 11.4% of pilots who reported a history of undisclosed prescription medication use (n = 30).

Conclusions
U.S. military pilots may participate in health care avoidance behavior because of fear for loss of flying status.
Do post-starburst galaxies host compact molecular gas reservoirs?
Authors: Sun Fengwu , Egami Eiichi 
Published: October 2022

ABSTRACT
We analysed the high-resolution (up to ∼0.2 arcsec) ALMA CO (2–1) and 1.3 mm dust continuum data of eight gas-rich post-starburst galaxies (PSBs) in the local Universe, six of which had been studied by a recent work. In contrast to this study reporting the detections of extraordinarily compact (i.e. unresolved) reservoirs of molecular gas in the six PSBs, our visibility-plane analysis resolves the CO (2–1) emission in all eight PSBs with effective radii (Re, CO) of $0.8_{-0.4}^{+0.9}$ kpc, typically consisting of gaseous components at both circumnuclear and extended disc scales. With this new analysis, we find that the CO sizes of gas-rich PSBs are compact with respect to their stellar sizes (median ratio $=0.43_{-0.21}^{+0.27}$), but comparable to the sizes of the gas discs seen in local luminous infrared galaxies (LIRGs) and early-type galaxies. We also find that the CO-to-stellar size ratio of gas-rich PSBs is potentially correlated with the gas depletion time-scale, placing them as transitional objects between LIRGs and early-type galaxies from an evolutionary perspective. Finally, the star formation efficiency of the observed PSBs appear consistent with those of star-forming galaxies on the Kennicutt–Schmidt relation, showing no sign of suppressed star formation from turbulent heating.