bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring fear of cancer recurrence in survivors of childhood cancer: Development and preliminary validation of the Fear of Cancer Recurrence Inventory (FCRI)‐Child and Parent versions
Authors: Tutelman Perri R. , Chambers Christine T. , Heathcote Lauren C. , Fernandez Conrad V. , Flanders Annette , Patton Michaela , Schulte Fiona S. M. , Guilcher Gregory M. T. , Simard Sébastien , MacLeod Julia , Stern Maya 
Published: January 2022

AbstractObjectiveFear of cancer recurrence (FCR) is a common and distressing psychosocial concern for adult cancer survivors. Data on this construct in child survivors is limited and there are no validated measures for this population. This study aimed to adapt the Fear of Cancer Recurrence Inventory‐Short Form (FCRI‐SF) for survivors of childhood cancer aged 8–18 years (Fear of Cancer Recurrence Inventory—Child version [FCRI‐C]) and their parents (Fear of Cancer Recurrence Inventory—Parent version [FCRI‐P]) to self‐report on their own FCR and to examine the initial psychometric properties.MethodsThe FCRI‐SF was adapted through expert panel input and cognitive interviews with child survivors <18 years. The factor structure, internal consistency and construct and criterion validity of the FCRI‐C and FCRI‐P were examined in 124 survivors of childhood cancer (43% female;Mage = 14.58 years,SD = 2.90) and 106 parents (90% mothers).ResultsAll FCRI‐SF items were retained for the FCRI‐C with simplified language. The internal consistencies of the FCRI‐C (α = 0.88) and FCRI‐P (α = 0.83) were good. Exploratory factor analyses yielded one‐factor structures for both measures. Higher scores on the FCRI‐C and FCRI‐P were associated with greater intolerance of uncertainty and pain catastrophizing. Higher child FCR was also related to more hypervigilance to bodily symptoms. Parents with higher FCR reported contacting their child's doctors and nurses and scheduling medical appointments for their child more frequently. Children reported significantly lower FCR compared to parents.ConclusionsThe FCRI‐C and FCRI‐P demonstrated strong reliability and preliminary validity. This study offers preliminary data to support the use of the FCRI‐C and FCRI‐P to measure FCR in survivors of childhood cancer aged 8–18 years and their parents.
The impact of the COVID‐19 pandemic on respiratory morbidity during infancy: A birth‐cohort study
Authors: Rosenfeld Nataly , Mandelberg Avigdor , Dalal Ilan , Tasher Diana , Kamar Alma , Schnapper Michael , Armoni Domany Keren 
Published: January 2022

AbstractObjectiveTo evaluate the incidence of wheezing and overall respiratory morbidity in healthy infants born during the first peak of the coronavirus disease‐2019 (COVID‐19) pandemic, compared with infants born during the preceding year.MethodsThis was a single‐center retrospective birth cohort study to compare a cohort of children born between February and March 2020 (COVID‐19 group) to a control group of children born between February and March 2019 (pre‐COVID‐19 group). At 1 year of age, we collected respiratory data using parental and telephone questionnaires. Primary outcome: wheezing incidence and/or bronchodilator use. Secondary outcomes: recurrent wheezing, emergency‐room visits, hospital admissions, pneumonia diagnosis, and admissions due to lower‐respiratory‐tract‐infections (LRTI). We included the following covariate risk factors in the logistic regression models; atopy, daycare attendance, breastmilk feeding, parental smoking, C‐section, siblings, and gestational age.ResultsWe enrolled 588 infants, 294 in each group (48% males). Demographic, perinatal, and atopic characteristics were similar between the groups. Compared to the pre‐COVID‐19 group, infants born during the COVID‐19 period were significantly less likely to report wheezing and/or bronchodilator use (adjusted‐odds ratio [OR], 0.4; 95% confidence interval [CI] 0.28–0.59), systemic steroid use, (adjusted‐OR, 0.47; 95% CI 0.24–0.91), emergency‐room visits (adjusted‐OR, 0.36; 95% CI 0.17–0.72), LRTI admissions (adjusted‐OR, 0.2; 95% CI 0.05–0.74), or pneumonia diagnosis (adjusted‐OR, 0.22; 95% CI 0.09–0.53).ConclusionsThis study investigated wheezing and respiratory morbidity over the first year of the COVID‐19 pandemic in infants born during the first peak of COVID‐19. The study demonstrated a significant decrease in most aspects of respiratory morbidity. A longitudinal follow‐up study to explore the subsequent impact of these findings is warranted.
Measurement of lung oxygenation by near‐infrared spectroscopy in preterm infants with respiratory distress syndrome: A proof‐of‐concept study
Authors: Dani Carlo , Ciarcià Martina , Miselli Francesca , Luzzati Michele , Petrolini Chiara , Corsini Iuri , Simone Pratesi 
Published: January 2022

AbstractIntroductionNoninvasive markers more accurate than FiO2 would be useful to assess the severity of RDS and guide its treatment. Our aim was to assess for the first time the possibility of continuously monitoring lung oxygenation (rSO2L) by near‐infrared spectroscopy (NIRS) and to evaluate whether rSO2L correlates with other oxygenation indices and RDS severity.MethodsWe carried out this proof‐of‐concept study on 20 preterm infants with RDS requiring noninvasive respiratory support. Patients were continuously studied for 24 h by NIRS and rSO2L was correlated with SpO2/FiO2 ratio, a/APO2, and O.I.ResultsThe overall value of rSO2L was 80.1 ± 6.2%, without significant differences between the right and left hemithorax (80.2 ± 6.7 vs. 80.0 ± 5.7%; p = 0.869). Mean values of total, right, and left rSO2L did not significantly change during the 24‐h study period. Linear regression analysis demonstrated a significant positive relationship between total rSO2L and SpO2/FiO2 ratio (p < 0.001) and a/APO2 (p = 0.040), and a negative relationship between total rSO2L and O.I. (r = −0.309; p = 0.022).ConclusionsContinuous monitoring of rSO2L by NIRS in preterm infants with RDS is feasible and safe. The correlation of rSO2L with other indices of oxygenation and RDS severity supports the accuracy and reliability of this measurement.
Quantitative Environmental Assessment of Explosive Residues from the Detonation of Insensitive High Explosive Filled 155 mm Artillery Shell
Authors: Persico Federica , Temple Tracey , Ladyman Melissa , Gilroy‐Hirst William , Guiterrez‐Carazo Encina , Coulon Frederic 
Published: January 2022

AbstractInsensitive High‐Explosive (IHE) typically comprises up to five constituents including 2,4‐dinitroanisole (DNAN), 3‐nitro‐1,2,4‐triazol‐5‐one (NTO), and 1,3,5‐trinitroperhydro‐1,3,5‐triazine (RDX), which are mixed in various ratios to achieve desired performance and increase insensitivity. Insensitive munitions, which are designed to detonate on command and not accidentally, are currently in use in military operations and training areas around the world. However, there is minimal literature available on the physiochemical behavior of these materials in the environment, therefore the actual consequence of residues being deposited post‐detonation is still an unexplored area of research. Three 155 mm artillery shells filled with an IHE mixture of 53 % NTO, 32 % DNAN, and 15 % RDX were detonated in an inert sand arena to collect and quantify residues. Post detonation, approximately 0.02 % NTO, and 0.07 % DNAN were deposited in the environment which may rapidly accumulate dependent on the number of rounds fired. This is of concern due to the toxicity of DNAN and its degradation products, and the potential for increased acidity of soil and discoloration of watercourses from NTO contamination.
Improvement in High Temperature‐Resistant Performance and Waterproof Property of Combustible Cartridge Case with BEMS Resin Based Composite Coating
Authors: Zhang Bin , Fu Enfa , Shi Haiyue , Zhang Xiang , Xiao Zhenggang 
Published: January 2022

AbstractCombustible cartridge case (CCC) is an important charge component which is very suitable for the weapon systems that need light load. It is a kind of nitrocellulose‐based porous material which has a low ignition temperature and strong hygroscopicity. Thus, if the surface of the CCC is not protected very well when it is used in modern weapon with faster fire rate, it will be easy to self‐ignite in the high‐temperature gun barrel and absorb moisture in a high‐humidity environment. These problems will worsen both the safety of gun operators and the combustion performance of CCC. However, they are not solved well by current research and industrial practice. Herein, we designed a new composite coating which can improve both the high temperature‐resistant performance at a higher temperature and waterproof property of CCC. The boron nitride (BN) and epoxy resin were used to modify silicone resin. The BN and epoxy modified silicone (BEMS) resin, inorganic adiabatic fillers and other additives were mixed together to prepare a BEMS resin based composite coating solution, and then the solution was sprayed on the surface of the combustible cartridge case to form a protective coating. The chemical structure of BEMS resin was investigated by FTIR. The thermal stability of coating films was analyzed by TGA. The high temperature‐resistant performance, water contact angle on the surface and waterproof property of the coated CCC were analyzed by muffle furnace experiment, water contact angle tester and immersion test, respectively. Results show that boron nitride and epoxy resin were successfully grafted on silicone resin chains. Compared with control samples, the thermal decomposition rate of the prepared coating films is significantly reduced. The coated CCC will keep 108.8 seconds while not burning at 230 °C. The heat resistant time increased by 16.74 % at 230 °C. The water contact angle on the surface of the coated CCC can reach 105.71° which was improved by 67.01°. After being soaked for one hour, the water absorption of the coated CCC is reduced by 96 % in distilled water and by 99 % in 3.5 wt % of sodium chloride solution. Compared with most present coatings, the new BEMS resin based composite coating which we designed can improve both the high temperature‐resistant performance and waterproof property of the CCC significantly and effectively. It provided a new way for study on the protective coating of CCC.
Chinese oak silkworm Antherae pernyi egg, a suitable factitious host for rearing eupelmid egg parasitoids
Authors: Chen Yong‐Ming , Iqbal Asim , Lv Rui‐E , Wang Xingeng , Desneux Nicolas , Zang Lian‐Sheng 
Published: January 2022

AbstractBACKGROUNDEupelmid egg parasitoids in the genera Anastatus and Mesocomys are important biological control agents for lepidopterous and hemipterous pests worldwide. The egg of Chinese oak silkworm Antheraea pernyi has been widely used for mass rearing of Trichogramma parasitoids. This study evaluated the suitability and optimal use methods of A. pernyi egg as a factitious host for the rearing of six eupelmid egg parasitoids (Anastatus fulloi, Anastatus gansuensis, Anastatus japonicus, Anastatus meilingensis, Mesocomys albitarsis and Mesocomys trabalae). Each parasitoid was tested for its oviposition preference and offspring performance on various differently treated host eggs (extracted from virgin moths or laid naturally by virgin or mated moths, and washed or unwashed prior to the use) in both no‐choice and choice tests.RESULTSAll treated A. pernyi eggs were readily parasitized by the six parasitoids. In general, A. gansuensis and M. trabalae preferred washed over unwashed eggs regardless of the fertilization status of host eggs, A. fulloi and A. meilingensis parasitized more unfertilized than fertilized host eggs, and A. japonicus and M. albitarsis did not show a preference among differently treated host eggs. Host egg treatment did not significantly affect offspring fitness (development time, survival, sex ratio and body size) nor reproductive potential of developed adult females for each parasitoid species, except for M. albitarsis (whose females contained more eggs when reared from unfertilized than fertilized host eggs).CONCLUSIONResults suggest that manually extracted, unfertilized and washed A. pernyi eggs are most suitable for mass rearing of these eupelmid egg parasitoids in biological control programs.
The effects of Silymarin on the features of cardiometabolic syndrome in adults: A systematic review and meta‐analysis
Authors: Soleymani Samaneh , Ayati Mohammad Hossein , Mansourzadeh Mohammad Javad , Namazi Nazli , Zargaran Arman 
Published: January 2022

AbstractSome medicinal herbs and their effective components showed positive effects on the features of the cardiometabolic syndrome (CMS). The aim of the present systematic review and meta‐analysis is to examine the effects of silymarin on the components of CMS in adults. Four electronic databases including PubMed/Medline, Scopus, Web of Science, and Embase were systematically searched up to December 31, 2020 to identify all eligible clinical trials. A random‐effect model using DerSimonian and Laird method was used to estimate the pooled weighted mean differences (WMDs) and the 95% confidence intervals (95%CIs). Finally, 11 clinical trials met the eligibility criteria. Our results demonstrated that silymarin significantly reduced the levels of fasting blood glucose (WMD: −17.96 mg/dL, 95% CI: −32.91, −3.02;I2: 82.4%, p < 0.001), hemoglobin A1C (WMD: −1.25%, 95% CI: −2.34, 0.16; I2: 92.9%, p ˂ 0.001), total cholesterol (WMD: −17.46 mg/dL, 95% CI: −30.98, −3.95; I2 = 62.9%, p = 0.006), triglyceride (WMD: −25.70 mg/dL, 95% CI: −47.23, −4.17; I2:54.3%, p = 0.025), low‐density lipoprotein‐cholesterol (WMD: ‐10.53, 95% CI: −19.12, −1.94; I2: 37.5%, p = 0.119) and increased high‐density lipoprotein‐ cholesterol (WMD: 3.36 mg/dL, 95% CI: 0.88, 5.84; I2: 37.4%, p = 0.120) compared to placebo. However, its effects on BMI were not statistically significant. Silymarin can be an effective complementary therapy to improve most features of CMS. However, due to high heterogeneity and limited clinical trials in some parameters, further high‐quality clinical trials are needed to confirm its efficacy.
Practical path planning techniques in overtaking for autonomous shuttles
Authors: Malayjerdi Ehsan , Sell Raivo , Malayjerdi Mohsen , Udal Andres , Bellone Mauro 
Published: January 2022

AbstractThis paper proposes a reliable optimized sigmoid‐based path planning algorithm that ensures smooth, fast and safe overtaking maneuver, while maintaining the necessary safety distance. In the proposed method, the desired smoothness of trajectories, the changes in steering angle and the lateral acceleration are controlled in a robust way. This paper describes the simulations, and the confirming real‐world experiments, conducted using the autonomous shuttle iseAuto. Our results suggest that the sigmoid A‐star algorithm leads to a smoother and more reliable motion when compared to other two standard methods. Specifically, the abruptness of necessary steering angle changes is reduced by factor of 4, and approaching the level of an experienced driver‐like maneuver.
Targeting Neuroblastoma by Limonoids from the Underutilized Fruits of Xylocarpus granatum
Authors: Munipalle Kiran , Kommalapati Vamsi Krishna , Patel Hemendra Kumar , Olanipekun Bolatito Eunice , Tangutur Anjana Devi , Ponnapalli Mangala Gowri 
Published: January 2022

AbstractChemical examination of the chloroform extract of the underutilized fruits of Xylocarpus granatum led to the isolation and identification of limonoids (3‐12) along with photogedunin C‐23 epimers. These compounds were characterized by means of spectroscopic data analysis and evaluated for their antiproliferation activity against a panel of four mammalian cancer cell lines; MIAPaCa‐2 (pancreatic), IMR‐32 (neuroblastoma), HeLa (cervical), and MCF‐7 (breast cancer) employing sulphorhodamine B assay. Among the evaluated compounds, photogedunin epimers exhibited moderate anticancer activity and inhibited the proliferation of neuroblastoma IMR‐32 cells. These epimers arrested cell cycle progression in the G2/M phase and also increased the sub G1 population. Furthermore, these epimers caused reactive oxygen species production, and cleavage of poly‐ADP‐Ribose polymerase (PARP), the crucial marker of apoptosis. These results demonstrated the molecular mechanism behind the antiproliferative effects of photogedunin epimers derived from the underutilized fruits of Xylocarpus granatum from the mangrove forest on IMR‐32 cells, indicating that these may be beneficial for the treatment of neuroblastoma.
Interaction of Ciprofloxacin with Arabinose, Glucosamine, Glucuronic Acid and Rhamnose: Insights from Genetic Algorithm and Quantum Chemistry
Authors: Coba‐Jiménez Ludis , Maza Julio , Guerra Mayamarú , Deluque‐Gómez Julio , Cubillán Néstor 
Published: January 2022

AbstractA theoretical study of the ciprofloxacin interactions with glucuronic acid, arabinose, glucosamine, and rhamnose is presented. The most stable complexes were obtained through genetic algorithms starting from the neutral and zwitterion species of ciprofloxacin. The energy at the semiempirical level PM7 of the optimal structures of the complexes was the genetic algorithm‘s fitness function. The resulting complexes’ geometry was optimized at M062X−D3/6‐311++G** level of theory, and non‐covalent interactions were assessed through the reduced density gradient and quantum theory of atoms in molecules. The results show that the zwitterion species of ciprofloxacin favorably complex carbohydrates and can induce proton exchange between them. The molecular complexes from proton exchange are the most stable, followed by the complexes formed by the contact of the zwitterion species and the carbohydrate. The complexes formed by both neutral species were the least stable. The medium strength and strong (assisted by charge) hydrogen bonds, the XH⋅⋅⋅π and lone‐pair⋅⋅π interactions, were mainly present in the complexes. Proton exchange processes strengthen the interactions mentioned above.
New α‐Imido‐β‐diarylphosphorylpropanoates and their Complexes with Gadolinium(III)
Authors: Il'in Anton V. , Serov Nikita Yu. , Khannanov Arthur A. , Solodov Alexander N. , Islamov Daut R. 
Published: January 2022

AbstractA practical route is described for the preparation of α‐imido‐β‐diarylphosphorylpropanoates based on the phosphine‐catalyzed α‐umpolung/β‐Michael addition reaction. One of the products has been tested for coordination the Gd3+ cation using NMR relaxation method in solution and by IR spectroscopy to solids. The exact structures of two isomers of the obtained complex have been determined by single crystal analysis. The structures of all isomers were investigated by quantum‐chemical calculations in solution. Quantum‐chemical calculations results show the presence of stereoselective effect in solution: the trans‐isomer with two ligands having different chirality is energetically more favorable. The cis‐isomer with ligands of different chirality is the least advantageous in terms of energy and therefore presents in solution in small amounts. The cis‐ and trans‐isomers with two ligands of the same chirality are very close in energy but are somewhat inferior to the most stable isomer.
Ultrasound estimation of fetal weight accuracy in a regional hospital: A retrospective audit
Authors: Spurway Jacqueline , Filce Casey , Luscombe Georgina 
Published: January 2022

AbstractIntroductionUltrasound estimated fetal weight (EFW) is a vital part of prenatal care. We aimed to determine the accuracy of sonographic EFW at a regional Australian hospital, explore factors associated with EFW accuracy and review accuracy calculation methods.MethodsUltrasound EFW (Hadlock C) was calculated within one week of a live delivery, for 357 singleton pregnancies. EFW accuracy, the difference between EFW, and live birthweight (LBW), were quantified using percentage error (PE); absolute error (AE); ‘signed’ error and AE ≤10% of LBW.ResultsEstimations of accuracy varied by calculation method, with PE smaller (mean 2.3% [CI 1.5, 3.1], median PE 2.4% [IQR −3.4, 6.7]) than AE (mean 6.4% [CI 5.9, 6.9], median AE 5.1% [IQR 2.7, 9.0]). Signed error indicated the majority of EFWs were overestimates and 80.1% of EFW calculations had an AE within 10% of LBW. EFW inaccuracy (AE ≥10% of LBW) varied between sonographers (p = .023) and scan to delivery interval (p = .003).ConclusionsEFW accuracy rates at the regional hospital were similar to published error rates. EFW accuracy varied with sonographer and with time from scan to delivery. Absolute error provides more useful and comparable information than percentage error of EFW.
Silver Mesoporous Silica Nanoparticles: Fabrication to Combination Therapies for Cancer and Infection
Authors: He Xuan , Chen Fangman , Chang Zhimin , Waqar Kasim , Hu Hanze , Zheng Xiao , Wang Yingshuai , Dong Wen‐fei , Yang Chao 
Published: January 2022

AbstractThe integration of silver nanoparticles (Ag NPs) with mesoporous silica nanoparticles (MSNs) protects the former from aggregation and promotes the controlled release of silver ions, resulting in therapeutic significance on cancer and infection. The unique size, shape, pore structure and silver distribution of silver mesoporous silica nanoparticles (Ag‐MSNs) embellish them with the potential to perform combined imaging and therapeutic actions via modulating optical and drug release properties. Here, we comprehensively review the recent progress in the fabrication and application of Ag‐MSNs for combination therapies for cancer and infection. We first elaborate on the fabrication of star‐shaped structure, core‐shell structure, and Janus structure Ag‐MSNs. We then highlight Ag‐MSNs as a multifunctional nanoplatform to surface‐enhanced Raman scattering‐based detection, non‐photo‐based cancer theranostics and photo‐based cancer theranostics. In addition, we detail Ag‐MSNs for combined antibacterial therapy via drug delivery and phototherapy. Overall, we summarize the challenges and future perspectives of Ag‐MSNs that make them promising for diagnosis and therapy of cancer and infection.
Deliberative democracy and the climate crisis
Authors: Willis Rebecca , Curato Nicole , Smith Graham 
Published: January 2022

ABSTRACTNo democratic state has yet implemented a climate plan strong enough to meet the goals of the Paris Agreement. This has led some to argue that democracy cannot cope with a challenge of this magnitude. In this article, we take stock of the claim that a more deliberative democratic system can strengthen our ability to respond effectively to the climate crisis. The most visible development in this direction is the recent citizens’ assemblies on climate change in Ireland, France, and the UK. We begin our analysis of the promise of deliberative democracy with a recognition of the difficulties that democracies face in tackling climate change, including short‐termism; the ways in which scientific and expert evidence are used; the influence of powerful political interests; and the relationship between people and the politicians that represent them. We then introduce the theoretical tradition of deliberative democracy and examine how it might ameliorate the challenges democracies face in responding to the climate crisis. We evaluate the contribution of deliberative mini‐publics, such as citizens’ assemblies and juries, and look beyond these formal processes to examine how deliberation can be embedded in political and social systems around the world. We conclude that deliberation‐based reforms to democratic systems, including but not limited to deliberative mini‐publics, are a necessary and potentially transformative ingredient in climate action.This article is categorized under:
Perceptions, Behavior, and Communication of Climate Change > Communication
Policy and Governance > Governing Climate Change in Communities, Cities, and Regions