bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering preparation of the territory in conditions of laying soft soil
Authors: Malyshev Oleg , Rashchenko Andrii , Dyptan Tetiana 
Published: July 2022

At present, in large cities, cities - millionaires, there is a tendency to build a large volume of residential multi-storey buildings entertainment complexes on undeveloped, free from construction areas of urban territory. Large cities and settlements are expanding due to the development of areas for buildings. The geological structure of this areas is difficult. In particular, the complexity is due not only to low values of physical and mechanical characteristics of soils, but also to special properties (high compressibility, decay of organic residues, unevenness and duration of sedimentation over time, etc.) [1, 5]. A certain part of the territory of our country is represented by peat soils, which to some extent can be considered as minerals, the use of which as a basis for buildings and structures is not rational and requires the use of special measures and construction works. When designing buildings and structures in such engineering and geological conditions, it is necessary to take into account that all types of geotechnical actions on the part of the deformed base on the building are reduced mainly to uneven vertical and horizontal deformations of the base surface. In order to ensure reliable operation of the building in such engineering geological conditions, it is necessary to make structural and technological decisions that will comprehensively take into account the complexity of the site and allow to implement the design solution. At the same time, practice of design and construction shows, quite often the listed unfavorable factors and dangerous processes are ignored, not taken into account or incorrect decisions are made to ensure the reliability of the basis.To solve this problem, the following tasks are relevant: a set of modern modeling tools (numerical calculation) and field observations, which allow you to analyze the results and take a reasonably correct (reliable, cost-effective) version of the base preparation for buildings or structures [2] to ensure reliable and safe operation of the building or structure.
Comparative assessment of the slope stability using different calculation methods
Authors: Nosenko Viktor , Skochko Liudmyla , Malaman Artur 
Published: July 2022

Comparison of the results of assessment of the of slope stability to determine the feasibility of construction of retaining structures is presented in this paper
The construction of a grain terminal on a landslide slope in the Odessa region was selected as the object of researching. The building area belongs to the Black Sea basin region and is located on the southwestern slope of the Ukrainian Crystal Shield. The uneven stepped surface of the crystalline basement consists of blocks. Despite the significant irregularities of the crystalline basement, they are reflected in the relief through the sedimentary cover. To ensure of the slope stability, it is planned to install a cascade of retaining structures. There are pile retaining walls.
The calculations are based on the analysis of the stress-strain state of the slope and anti-landslide structures using two fundamentally different methods. These methods of calculation using modern software:
- analytical method for assessing the slope stability (limit equilibrium method);
- assessment of the slope stability by the method of numerical modeling of the stress-strain state of the elements of the system "soil mass - anti-landslide structures".
Calculations were made for two calculated cross-sections and for different stages of construction. There are stages native state, during construction and exploitation. 1st stage is assessment of the slope stability in its natural state, before building beginning. 2nd stage is assessment of the slope stability during the construction of the 1st retaining wall and excavations of the first level of the pit; stage 3 - assessment of slope stability after construction of anti-landslide structures and excavations of the pit. Stage 4 - assessment of the slope stability at the stage of grain terminal exploitation, it is meaning the construction of foundation structures.
According to the results of calculations, the slope stability safety factors were determined, the analysis of SSS elements of the system "soil mass - landslide structures" was carried out and the reinforcement of retaining walls was selected.
Gravity Studies at Cerro Machín Volcano, Colombia
Authors: Pedraza Nicolás Felipe , Velazquez Juan Diego , Molina Indira , Pedraza Andrés 
Published: July 2022

A gravimetric study was performed at the Cerro Machin volcano (4° 29’ N, 75° 22’ W), Tolima Department, Colombia, to obtain a density distribution of the volcanic edifice and its basement. This study was divided into three main sections. The first section consisted of gravimetric measurements on the volcano, which were performed with a Scintrex Autograv CG-5 gravimeter. In the second section, a complete Bouguer anomaly was obtained by applying gravimetric corrections to the field data, such as instrumental drift, latitude, free-air, Bouguer, and topographic corrections. For the third section, we used the GM-SYS extension of Oasis Montaj to obtain a forward model of the subsurface density distribution that allowed us to explain the source of the gravimetric anomaly. As the main results for this study, we determined that the field-obtained Bouguer anomaly ranged between -87 mGal and -29 mGal in the study area. The Oasis Montaj density model allowed us to infer an elongated dacitic complex at the top of the distribution with a mean density of 2300 kg/m3, with the presence of a volcanic conduit of 2400 kg/m3 at the base. The seismicity in the area suggests that the gravimetric anomaly caused by the dome and its surrounding materials may be related to a large weakened zone at the interface between the volcanic edifice and the metamorphic basement, provoked by fault activity, interaction with the hydrothermal system and the ascent of hot, fluid material to the surface. This study suggests one interpretation of the Machin dome volcanic complex and encourages further gravimetric studies and modeling over a wider area.
Prostat Kanseri Kök Hücrelerinde Zoledronik Asit Tedavisinin Hücre Adezyon Moleküllerine Etkisi
Authors: SONER Burak Cem , AÇIKGÖZ Eda , ÖKTEM Gülperi , ÇAL Çağ 
Published: July 2022

Prostat kanserinin tanı ve tedavisine yönelik birçok alanda ilerleme sağlanabilmesine rağmen hastalık bazı vakalar için ölümcül olma niteliğini sürdürmektedir. Hastaların ölümden kurtulması için atılan her adım hedefe yaklaşılmasına yardım etse de halen sonuca ulaşmak için araştırılması gereken pek çok konu bulunmaktadır.
Kök hücrenin keşfi ile bu hücrelerin insan sağlığı için önemi anlaşılmış ve tedavide nasıl kullanılacağının belirlenmesine yönelik çalışmalar büyük hız kazanmıştır. İlerleyen yıllarda Kanser Kök Hücresi kavramı ortaya çıkmış ve bu hücrelerin, kök hücre özelliklerini taşıyan ancak tümör dokusu içinde metastazı yapan, tedavi sonrası nükse yol açabilen veya tedaviye direnç̧ geliştiren hücreler oldukları belirlenmiştir. Köklülük özelliğine sahip bu hücreler dışında kalan hücre gurubu kanser kök hücresi olmayan hücre gurubudur ve konvansiyonel kanser tedavisine cevap veren kanser hücrelerdir. Kanserin metastaz yapması ve çevre dokuya invazyonunda adezyon moleküllerinin önemi büyüktür. Yapılan çalışmalar özellikle çoklu ilaç direnci ve epitelial mezenşimal geçişte adezyon moleküllerinin büyük önem kazandığını göstermiştir.
Bu çalışmanın amacı prostat kanseri kök hücreleri üzerine zoledronik asit uygulaması sonrası, metastaz geliştirme sürecinde önemli rolü olan adezyon molekülleri üzerine etkisinin incelenmesidir. Bu amaçla DU145 insan prostat kanseri hücre hattından akım sitometri cihazı ile CD133/CD44 yüzey belirteçleri kullanılarak izole edilen kanser kök hücreleri üzerine zoledronik asit tedavisi uygulanmıştır. Kanser kök hücresinde oluşan değişiklikler adezyon molekülleri yönü ile araştırılmıştır. Elde edilen sonuçlar zoledronik asit tedavisi sonrası kanser kök hücresi sayısında önemli bir düşüş olduğunu ve bu uygulamanın CD44, ITGB1, CD29, LAMB1, LAMB3, LAMC1, SPP1, TGFB1, TGFB1, TIMP2, ADAMTS1, ITGB5’de önemli değişimlere yol açtığını göstermiştir.
Bu çalışmada in-vitro ortamda zoledronik asit uygulamasının kanser kök hücresi adezyon molekülleri üzerine baskılayıcı etki oluşturduğu ve ilerleyen çalışmalarda bu ilacın klinik kullanımda prostat kanseri tedavisinde uygulanabilme olasılığının olduğunu göstermiştir.
Phlebitis associated with peripheral venous catheter placement: systematic review
Authors: Ulloa Heras Leonor del Rocío , Salas Contreras Francy Hollminn , Morgado Tapia María Gabriela 
Published: July 2022

Peripheral venous catheter (PVC) is often a common application we use for patient care worldwide for intravenous (IV) fluid administration. Objective: to examine the scientific literature on phlebitis associated with peripheral venous catheter placement through systematic review. Methodology: it is a literature review for the realization of this process, the recommendations of the PRISMA method will be followed. Main results: the worldwide prevalence of phlebitis was Australia 12%, Portugal 11.5%, Germany 7.6%, Spain 5.6%, Portugal 36.7%. Risk factors: age, venipuncture site, venous catheter size, failed attempts, and HIV drugs, diabetic patients, immunosuppressive drugs, venipuncture site, cathlon number 18. Risk factors for phlebitis: age, sex, venipuncture site, large venous catheters, failed attempts, hypertonic fluids, antibiotics. Conclusion: the staff should know the symptoms of phlebitis, monitor the site where the peripheral venous line was placed, the anatomical part should focus on the caliber of the venous catheter, the care should be comfortable and safe, thus increasing the quality of care and avoiding complications such as inflammation,
Efektivitas model pembelajaran Generatif terhadap hasil belajar matematika siswa Kelas XII SMAN 5 Batam
Authors: Adriani Nurliza , Hanggara Yudhi , Amelia Fitrah 
Published: July 2022

Penelitian ini bertujuanuuntuk mengetahui efektivitas model pembelajaran generatif terhadap hasil belajar matematika siswa kelas XII SMAN 5 Batam. Jenis penelitian ini adalah penelitian quasi experimental dengan desain penelitian post-test only control design. Populasi dalam penelitian ini adalah seluruh siswa kelas XII SMAN 5 Batam. Subjek pada penelitian ini adalah siswa kelas XII IPS 1 yang berjumlah 46 siswa sebagai kelas eksperimen dan kelas XII IPS 2 yang berjumlah 46 siswa sebagai kelas kontrol. Teknik pengambilan sampel dilakukan dengan teknik cluster random sampling. Data diperoleh dengan instrumen tes sebanyak 5 butir soal uraian yang validitas dan reliabel. Teknik analisis data yang digunakan adalah uji normalitas, uji homogenitas dan uji hipotesis yang meliputi uji one sampel t-Test dan independent sample t-Test. Berdasarkan hasil analisis data, 1)Model pembelajaran Generatif efektif terhadap hasil belajar matematika siswa kelas XII IPS SMAN 5 Batam Tahun Ajaran 2021/2022. 2)Model pembelajaran Direct Instruction tidak efektif terhadap hasil belajar matematika siswa kelas XII IPS SMAN 5 Batam Tahun Ajaran 2021/2022. 3)Terdapat perbedaan keefektifan model pembelajaran Generatif dan model pembelajaran Direct Instruction terhadap hasil belajar matematika siswa kelas XII SMAN 5 Batam Tahun Ajaran 2021/2022.
In-situ Temperature Stations Elucidate Species’ Phenological Responses to Climate in the Alps, but Meteorological and Snow Reanalysis Facilitates Broad Scale and Long-Term Studies
Authors: Laigle Idaline , Carlson Bradley Z. , Delestrade Anne , Bison Marjorie , Van Reeth Colin , Yoccoz Nigel Gilles 
Published: July 2022

Linking climate variability and change to the phenological response of species is particularly challenging in the context of mountainous terrain. In these environments, elevation and topography lead to a diversity of bioclimatic conditions at fine scales affecting species distribution and phenology. In order to quantifyin situclimate conditions for mountain plants, the CREA (Research Center for Alpine Ecosystems) installed 82 temperature stations throughout the southwestern Alps, at different elevations and aspects. Dataloggers at each station provide local measurements of temperature at four heights (5 cm below the soil surface, at the soil surface, 30 cm above the soil surface, and 2 m above ground). Given the significant amount of effort required for station installation and maintenance, we tested whether meteorological data based on the S2M reanalysis could be used instead of station data. Comparison of the two datasets showed that some climate indices, including snow melt-out date and a heat wave index, can vary significantly according to data origin. More general indices such as daily temperature averages were more consistent across datasets, while threshold-based temperature indices showed somewhat lower agreement. Over a 12 year period, the phenological responses of four mountain tree species (ash (Fraxinus excelsior), spruce (Picea abies), hazel (Corylus avellana), birch (Betula pendula)), coal tits (Periparus ater) and common frogs (Rana temporaria) to climate variability were better explained, from both a statistical and ecological standpoint, by indices derived from field stations. Reanalysis data out-performed station data, however, for predicting larch (Larix decidua) budburst date. Overall, our study indicates that the choice of dataset for phenological monitoring ultimately depends on target bioclimatic variables and species, and also on the spatial and temporal scale of the study.
Outcomes in AB0 Incompatible Living Donor Kidney Transplantation: A Case – Control Study
Authors: Cozzi Martina , Donato Paola , Ugolini Gabriele , Nguefouet Momo Rostand Emmanuel , Nacchia Francesco , Ballarini Zeno , Piccoli Pierluigi , Cantini Maurizio , Caletti Chiara , Andreola Stefano , Gandini Giorgio , Gambaro Giovanni , Boschiero Luigino 
Published: July 2022

BackgroundPatients waiting for a kidney transplant by far exceed available organs. AB0 incompatible living donor kidney transplantation (AB0i LDKT) represents an additional therapeutic strategy, but with higher risk for complications. We aimed at evaluating outcomes of AB0i LDKTs compared to compatible (AB0c) controls at our Institution.MethodsRetrospective matched case – control study (1:2) comparing AB0i vs. AB0c LDKTs from March 2012 to September 2021. Considered outcomes: graft function, acute rejection, sepsis, CMV infection, BK virus reactivation, death-censored graft survival, patient survival.ResultsSeventeen AB0i LDKTs matched to 34 AB0c controls. We found excellent graft function, comparable in the two groups, at all considered intervals, with an eGFR (ml/min/1.73 m2) of 67 vs. 66 at 1 year (p = 0.41), 63 vs. 64 at 3 years (p = 0.53). AB0i recipients had a statistically significant higher incidence of acute rejection, acute antibody-mediated rejection and sepsis within 30 days (p = 0.016; p = 0.02; p = 0.001), 1 year (p = 0.012; p = 0.02; p = 0.0004) and 3 years (p = 0.004; p = 0.006; p = 0.012) after surgery. There was no difference in CMV infection, BK virus reactivation, death-censored graft survival between the two groups. Patient survival was inferior in AB0i group at 1 and 3 years (88.2 vs. 100%; log-rank p = 0.03) due to early death for opportunistic infections. AB0i LDKTs spent longer time on dialysis (p = 0.04) and 82.3 vs. 38.3% controls had blood group 0 (p = 0.003).ConclusionsAB0i LDKT is an effective therapeutic strategy with graft function and survival comparable to AB0c LDKTs, despite higher rates of acute rejection and sepsis. It is an additional opportunity for patients with less chances of being transplanted, as blood group 0 individuals.
Comparative analysis of aroma components and quality of Geotrichum candidum after space mutation breeding
Authors: Chen Junjie , Li Qianying , Wang Jie , Chen Weizhe , Zheng Qikai , Zhong Qingping , Fang Xiang , Liao Zhenlin 
Published: July 2022

AimThe aroma-producing strain of Geotrichum candidum GDMCC60675 was taken as the research object, the composition of aroma-producing substances of G. candidum was studied, and the target strains of G. candidum suitable for food additives were screened out by mutagenesis.MethodsMutants were obtained by space breeding. The colony morphology and cell morphology of the mutant strain were identified, the phylogenetic tree of the two strains was constructed, and the whole-genome sequences of the wild strain and the mutant strain were compared. The aroma components and key odor compounds of the two strains were analyzed and compared by HS-SPME-GC-MS and E-nose detection, and the data were processed by using the relative odor activity value (ROAV) analysis method.ResultsA mutant strain of G. candidum was found with different characteristics of aroma production compared with wild-type G. candidum. It was found that its colony morphology and cell morphology were similar. However, it was found that the aroma-producing substances produced by the two strains were different, and the key difference compound was phenyl ethyl alcohol, which also proved that the two strains were different, and the main aroma note was different.
Periventricular white matter hyperintensities are associated with gait and balance in patients with minor stroke
Authors: Su Chen , Yang Xiaoyu , Wei Shuqi , Zhao Renliang 
Published: July 2022

ObjectiveCerebral small vessel disease (CSVD) is associated with gait and balance deficits in older adults. However, the effect of CSVD-related brain injury on post-stroke mobility is unknown. This study aimed to investigate the association of CSVD with gait and balance impairment after a minor stroke.MethodsA total of 273 patients with a minor stroke (NIHSS ≤ 5 points) who were hospitalized at the Affiliated Hospital of Qingdao University were enrolled. The manifestations of white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces (EPVS), and cerebral microbleeds (CMB) were statistically analyzed according to magnetic resonance imaging results, and the total burden score of CSVD was calculated. Gait function was assessed by a 6-m walking speed test, and balance function was assessed by the timed-up-and-go (TUG) test. Linear regression analysis was applied to determine the association after adjusting for key variables.ResultsThe correlation results showed that in patients with minor stroke, age, sex, smoking history, and the infarct site were associated with gait speed, and age and the infarct site were associated with the TUG test. In the univariate linear regression model, periventricular white matter hyperintensities (PVWMH), deep white matter hyperintensities (DWMH), and the total burden of CSVD were correlated with gait speed, while only PVWMH correlated with the TUG test. After adjusting for confounders, only PVWMH were independent predictors of gait speed (β = −0.089,p&lt; 0.05) and the TUG test (β = 0.517,p&lt; 0.05).ConclusionsOur study confirmed that CSVD is associated with gait and balance disorders after a minor stroke. PVWMH are independent predictors of gait and balance disorders in patients with minor stroke. These findings should be confirmed in larger prospective studies.
A Combination of Green Tea, Rhodiola, Magnesium, and B Vitamins Increases Electroencephalogram Theta Activity During Attentional Task Performance Under Conditions of Induced Social Stress
Authors: Boyle Neil Bernard , Dye Louise , Lawton Clare Louise , Billington Jac 
Published: July 2022

BackgroundA combination of green tea, rhodiola and magnesium with B vitamins has previously been reported to significantly increase EEG resting state theta, attenuate subjective stress, anxiety and mood disturbance, and heighten subjective and autonomic arousal under acute psychosocial laboratory stress. Here we examine the capacity of green tea and rhodiola extract administered in combination or in isolation with magnesium and B vitamins to moderate spectral brain activity during attentional task performance under stress.Materials and MethodsOne-hundred moderately stressed adults received oral supplementation of (i) Mg + B vitamins + green tea + rhodiola; (ii) Mg + B vitamins + rhodiola; (iii) Mg + B vitamins + green tea; or (iv) placebo, in a double-blind, randomised, placebo-controlled, parallel-group design (Clinicaltrials.gov: NCT03262376; 25/0817). Participants completed an attention switching and emotionally threatening attentional bias task after stress induction (Trier Social Stress Test). Spectral alpha and theta brain activity and event related potentials (ERPs) were recorded during cognitive task performance by electroencephalogram (EEG; BioSemi ActiveTwo 64 channel).ResultsThe combined treatment of Mg + B vitamins + green tea + rhodiola significantly increased frontal midline theta vs. placebo and rhodiola in isolation during the attention switching task, specifically in anticipation of a change in task performance parameter. The combined treatment also significantly increased contralateral theta activation in relation to viewing emotionally threatening images in the left (vs. placebo and rhodiola in isolation) and right parietal (vs. placebo) regions. Further, this treatment demonstrated significantly heightened ipsilateral left parietal theta activation in relation to viewing emotionally threatening images. The combined treatment attenuated a decrease in alpha power during the attentional bias task evident in comparator treatments, but this did not reach significance. No significant effects of treatments on behavioural performance or ERP were found.ConclusionThe combination of Mg + B vitamins + green tea + rhodiola increased spectral theta brain activity during the execution of two attentional tasks suggestive of a potential to increase attentional capacity under conditions of stress. Further examination of these ingredients in relation to attentional performance under stress is warranted to ascertain if functional benefits suggested by theta activation can be shown behaviourally.
Case report: Temporal alterations in vascular function during the first 2 weeks of pediatric septic shock
Authors: Wijers Christiaan Diederik Mathijs , Stark Ryan J. 
Published: July 2022

IntroductionDuring sepsis and septic shock, the host's immune systems generate an overwhelming and often, detrimental, inflammatory response. Part of this response results in significant alterations in blood flow and vasomotor tone regulated in part by endothelial and vascular smooth muscle cells. Here, we report on a series of 3 pediatric patients for whom vascular response was assessed by laser doppler perfusion coupled to iontophoresis over the first 2 weeks after hospitalization for septic shock to demonstrate similarities and dissimilarities in the vascular response.Case PresentationsA 12-year-old male with a history of Burkitt's Lymphoma, a 21-year-old male with congenital porencephaly and epilepsy, and a 7-year-old male with no significant past medical history all were admitted to a tertiary care children's hospital with a diagnosis of septic shock requiring vasoactive infusions to maintain mean arterial blood pressure. Non-invasive laser doppler perfusion coupled with iontophoresis of either acetylcholine (endothelial-dependent response) or sodium nitroprusside (endothelial-independent response) was performed on hospital days 1, 3, 7, and 14. Variability and heterogeneity were demonstrated by the temporal assessments of the vascular response to sodium nitroprusside, but all three patients showed significant similarity in the temporal responsiveness to acetylcholine.ConclusionAssessment of baseline and temporal responsiveness to endothelial-dependent vascular reactivity may provide a predictable timeline to the resolution of pediatric septic shock.