bluuebunny/crossref_metadata_2025_split huggingface dataset:
GAMIFYING “WHOLE-PERSON EDUCATION”: THE DEVELOPMENT OF A MOBILE APPLICATION WITH AUGMENTED REALITY
Authors: Marcial Dave E. , Dy Joy M. , Montemayor Jade O. 
Published: October 2022

Whole-person education is what many educational institutions aim for, especially in these times of rapid technological innovations. Silliman University, one of the oldest universities in the Philippines, offers whole-person education to achieve total human development. This study is an innovative technology integration in the classroom of the course “whole-person education”. Specifically, this paper describes the development of a mobile game application that integrates augmented reality. Applying the gamification theory, a learning trail about the 5Cs of Silliman Education - Classroom, Church, Culture, Court, and the Community, was integrated. The learning trail consists of three learning paths, and each path consists of ten checkpoints. Three qualifying questions were embedded to determine the player’s learning path. Each checkpoint is augmented using QR codes. Players need to complete the game in the shortest possible time. The educational game mobile application was developed using Appery.io, a rapid development, integration, and deployment platform. The mobile application runs on the Android operating system as part of the first release. A survey was conducted among 244 players of the game application. A 4-point scale questionnaire is integrated into the game app, asking the players about their level of agreement with the statements representing their game evaluation. The result shows that the game application was evaluated positively by the respondents, with a mean of 3.69. Expressly, the players agreed ( = 3.69) that they learned a lot about the AR trail. The students also agreed ( = 3.35) to the statement, “I would like my teachers to integrate apps like this in my classes.” The result implies that augmented reality and gamification as teaching strategies in the classroom are perceived positively and accepted by the students. The educational game promotes the understanding of whole-person education especially in a developing country where digital divide is a pressing issue.
PENERAPAN MODEL PEMBELAJARAN AQIDAH AKHLAK BERBASIS PROJECT BASED LEARNING DI MADRASAH ALIYAH NURUL ISLAM NGESREP BOYOLALI
Authors: Firda Ainul Luthfia Al , Pamungkas Nikmatul Choiroh 
Published: October 2022

Rendahnya minat anak didik khususnya dalam belajar aqidah akhlak di MA Nurul Islam Boyolali menjadi latar belakang dari penelitian ini. Rendahnya minat tersebut ditandai dengan monotonnya metode pembelajaran aqidah akhlak dengan metode verbalistik. Hal ini menimbulkan kejenuhan siswa dalam belajar. Beberapa guru juga terbentur dengan keterbatasan dalam penggunaan tekhnologi. Oleh sebab itu pengembangan metode belajar dirubah dengan gaya pembelajaran project based learning (PjBL). Tujuan dari penelitian ini untuk melihat efektifitas penerapan metode pembelajaran aqidah akhlak berbasis project based learning di MA Nurul Islam Boyolali. Metode penelitian menggunakan metode tindakan kelas dengan tahap perencanaan dan praktik tindakan kelas. Hasil penelitian menyatakan sebagian besar anak didik mulai tertarik untuk belajar aqidah akhlak, mulai memperdalam ilmu agama, aktif dan kooperatif dalam kerja kelompok, inovatif, kritis mampu memecahkan masalah dan manajemen waktu, serta ketertarikan pada suatu mata pelajaran cinderung meningkat.Kata Kunci : Metode Pembelajaran, Project Based Learning, Pendidikan
PENINGKATAN PENGUASAAN KONSEP SISWA PADA MATERI GERAK LURUS MELALUI PEMBELAJARAN MODELING INSTRUCTION
Authors: Hidayah Nurul , Yunitasari Indah , Aini Meliyana 
Published: October 2022

Topik kinematika dalam ilmu fisika masih menjadi salah satu materi yang terdapat kesulitan bagi siswa dalam mempelajarinya. Kesulitan yang dialami siswa mengakibatkan siswa mengalami kesalahpahaman konsep dalam menguasai materi kinematika seperti konsep posisi, kecepatan, dan percepatan. Modeling Instruction merupakan salah satu model pembelajaran yang melibatkan siswa aktif dalam pembelajaran. Tujuan penelitian ini untuk meningkatkan penguasaan konsep siswa pada materi gerak lurus melalui Modeling Instruction. Pada penelitian ini digunakan metode penelitian kuantitatif. Data penelitian diperoleh dari hasil pretest dan posttest. Selanjutnya ditentukan uji normalitas yang selanjutnya untuk mengetahui peningkatan penguasaan konsep siswa dilakukan uji beda dengan N-gain. Hasil uji formalitas diperoleh hasil -1 sampai 1 sehingga data dikatakan terdistribusi normal. Selanjutnya dilakukan uji beda dengan N-gain dengan hasil 0,30 artinya ada peniingkatan penguasaan konsep siswa dengan kategori medium bawah
Efectos del yoga en la calidad de vida de pacientes pediátricos con diagnóstico de cáncer: un estudio piloto
Authors: Sanhueza-Ramírez Massiel , Oyanadel Cristián , Peñate-Castro Wenceslao 
Published: October 2022

Objetivo: Describir el efecto de un programa piloto de yoga en la calidad de vida de pacientes pediátricos con cáncer en tratamiento ambulatorio con quimioterapia.
Método: diseño mixto, cuasi-experimental, pre-post. Se reclutaron participantes entre 6 a 10 años, ocho completaron todo el programa. El programa consideró 6 sesiones grupales de Hatha yoga. Se utilizaron las escalas Calidad de Vida pediátrica versión genérica y específica del cáncer (Pediatric Quality of life inventory (PedsQl) 4.0 y 3.0). Se realiza una entrevista semi-estructurada para identificar beneficios percibidos por el/la cuidador/a.
Resultados: Los datos cuantitativos no muestran diferencias significativas en resultados de calidad de vida antes y después del programa, pero cualitativamente se reportaron beneficios en las entrevistas a cuidadores en las categorías del dolor, resistencia física y estado de ánimo.
Conclusiones: Este estudio piloto aporta a la implementación de futuras investigaciones que incorporen el yoga en oncología pediátrica en un entorno hospitalario.
Corrigendum: Microalgae-based wastewater treatment for developing economic and environmental sustainability: Current status and future prospects
Authors: Srimongkol Piroonporn , Sangtanoo Papassara , Songserm Pajareeya , Watsuntorn Wannapawn , Karnchanatat Aphichart 
Published: October 2022

Graphical AbstractA biorefinery based on microalgae promotes a circular-green economic model.
Porcn is essential for growth and invagination of the mammalian optic cup
Authors: Fuhrmann Sabine , Ramirez Sara , Mina Abouda Mirna , Campbell Clorissa D. 
Published: October 2022

Microphthalmia, anophthalmia, and coloboma (MAC) are congenital ocular malformations causing 25% of childhood blindness. The X-linked disorder Focal Dermal Hypoplasia (FDH) is frequently associated with MAC and results from mutations in Porcn, a membrane bound O-acyl transferase required for palmitoylation of Wnts to activate multiple Wnt-dependent pathways. Wnt/β-catenin signaling is suppressed in the anterior neural plate for initiation of eye formation and is subsequently required during differentiation of the retinal pigment epithelium (RPE). Non-canonical Wnts are critical for early eye formation in frog and zebrafish. However, it is unclear whether this also applies to mammals. We performed ubiquitous conditional inactivation of Porcn in mouse around the eye field stage. In PorcnCKO, optic vesicles (OV) arrest in growth and fail to form an optic cup. Ventral proliferation is significantly decreased in the mutant OV, with a concomitant increase in apoptotic cell death. While pan-ocular transcription factors such as PAX6, SIX3, LHX2, and PAX2 are present, indicative of maintenance of OV identity, regional expression of VSX2, MITF, OTX2, and NR2F2 is downregulated. Failure of RPE differentiation in PorcnCKO is consistent with downregulation of the Wnt/β-catenin effector LEF1, starting around 2.5 days after inactivation. This suggests that Porcn inactivation affects signaling later than a potential requirement for Wnts to promote eye field formation. Altogether, our data shows a novel requirement for Porcn in regulating growth and morphogenesis of the OV, likely by controlling proliferation and survival. In FDH patients with ocular manifestations, growth deficiency during early ocular morphogenesis may be the underlying cause for microphthalmia.
Evaluation of the in vitro antioxidant and antitumor activity of extracts from Camellia fascicularis leaves
Authors: Peng Xiaowei , He Xuhua , Tang Junrong , Xiang Jianying , Deng Jia , Kan Huan , Zhang Yingjun , Zhang Guiliang , Zhao Ping , Liu Yun 
Published: October 2022

Camellia fascicularis is a unique plant rich in bioactive components. However, the isolation of the active substances in C. fascicularis leaves via sequential extraction with solvents of different polarity and the determination of their antioxidant and antitumor activities have not been reported. In this study, the total methanol extract of C. fascicularis leaves was sequentially extracted with different polar solvents, and the corresponding petroleum ether extract (PEE), ethyl acetate extract (EAE), and water extract (WE) were analyzed for their contents in active substances such as flavonoids, polyphenols, polysaccharides, and saponins. The antioxidant ability of the polar extracts was investigated by determining their reducing power and the radical scavenging rate on 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radicals, and CCK-8 and Annexin-FITC/propidium iodide staining assays were conducted to investigate their inhibitory effects on HCCLM6 and HGC27 tumor cells. The results showed that PEE had a high saponin content of 197.35 ± 16.21 mg OAE/g, while EAE and WE exhibited a relatively higher polysaccharide content of 254.37 ± 1.99 and 373.27 ± 8.67 mg GE/g, respectively. The EAE demonstrated the greatest reducing power and the strongest clearing abilities on ABTS and DPPH radicals with respective EC50 values of 343.45 ± 20.12 and 14.07 ± 0.06 μg/ml. Moreover, the antitumor ability of the different polar extracts was dose-dependent, with WE showing the most potent inhibitory ability against HCCLM6 and HGC27 cells.
Associations between common sleep disturbances and cardiovascular risk in patients with obstructive sleep apnea: A large-scale cross-sectional study
Authors: Zhang Xiaoman , Huang Weijun , Xu Huajun , Li Xinyi , Wang Fan , Wu Kejia , Li Chenyang , Liu Yupu , Zou Jianyin , Zhu Huaming , Yi Hongliang , Guan Jian , Qian Di , Yin Shankai 
Published: October 2022

ObjectivesStudies have shown that obstructive sleep apnea (OSA) is inextricably linked with cardiovascular diseases (CVD). However, the roles of certain common sleep disturbances, such as low slow-wave sleep, excessive daytime sleepiness and short sleep duration, in the pathogenesis and progression of CVD in patients with OSA have not been determined. Therefore, we conducted a large cross-sectional study to explore the effect of low slow-wave sleep, excessive daytime sleepiness and short sleep duration on the risk of CVD in patients with OSA.MethodsSubjects were consecutively enrolled to participate in the sleep center of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital. All OSA patients were diagnosed by standard polysomnography, while controls were all simple snorers. A total of 4,475 participants were strictly recruited. The Framingham Risk Score were employed to assess the 10-year risk of CVD, and logistic regression was used to measure the association between sleep disturbances and the moderate-to-high CVD risk.ResultsIn the whole cohort, OSA, excessive daytime sleepiness, and low slow-wave sleep were all risk factors for the moderate-to-high 10-year CVD risk (odds ratio [OR] = 3.012, 95% confidence interval [CI] 2.418–3.751; OR = 1.407, 95% CI: 1.228–1.613, and OR = 0.973,95% CI: 0.967–0.980), but sleep duration did not contribute significantly to that risk. Whether in patients with OSA and controls, low SWS (&lt;12.8%) could increase the risk of CVD. Subjective excessive daytime sleepiness would significantly increase the risk of CVD only in patients with severe OSA.ConclusionIt is important to pay more attention to the impact of sleep on cardiovascular health. Patients with sleep disturbances should adopt a healthy lifestyle and undergo regular follow-up of cardiovascular indicators to prevent cardiovascular complications.Trial registration[http://www.chictr.org.cn/showproj.aspx?proj=43057], identifier [ChiCTr1900025714].
Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression
Authors: Sinha Manish D. , Azukaitis Karolis , Sladowska-Kozłowska Joanna , Bårdsen Tonje , Merkevicius Kajus , Karlsen Sletten Ida Sofie , Obrycki Łukasz , Pac Michał , Fernández-Aranda Fernando , Bjelakovic Bojko , Jankauskiene Augustina , Litwin Mieczysław ,   HyperChildNet Working Group
Published: October 2022

BackgroundLeft ventricular hypertrophy (LVH) is the main marker of HMOD in children and young people (CYP). We aimed to assess the prevalence of LVH and its determinants in CYP with primary hypertension (PH).MethodsA meta-analysis of prevalence was performed. A literature search of articles reporting LVH in CYP with PH was conducted in Medline, Embase, and Cochrane databases. Studies with a primary focus on CYP (up to 21 years) with PH were included. Meta-regression was used to analyze factors explaining observed heterogeneity.ResultsThe search yielded a total of 2,200 articles, 153 of those underwent full-text review, and 47 reports were included. The reports evaluated 51 study cohorts including 5,622 individuals, 73% male subjects, and a mean age of 13.6 years. LVH was defined as left ventricle mass index (LVMI) ≥ 95th percentile in 22 (47%), fixed cut-off ≥38.6 g/m2.7 in eight (17%), sex-specific fixed cut-off values in six (13%), and miscellaneously in others. The overall prevalence of LVH was 30.5% (95% CI 27.2–33.9), while heterogeneity was high (I2 = 84%). Subgroup analysis including 1,393 individuals (76% male subjects, mean age 14.7 years) from pediatric hypertension specialty clinics and LVH defined as LVMI ≥95th percentile only (19 study cohorts from 18 studies), reported prevalence of LVH at 29.9% (95% CI 23.9 to 36.3), and high heterogeneity (I2 = 84%). Two studies involving patients identified through community screening (n = 1,234) reported lower LVH prevalence (21.5%). In the meta-regression, only body mass index (BMI) z-score was significantly associated with LVH prevalence (estimate 0.23, 95% CI 0.08–0.39, p = 0.004) and accounted for 41% of observed heterogeneity, but not age, male percentage, BMI, or waist circumference z-score. The predominant LVH phenotype was eccentric LVH in patients from specialty clinics (prevalence of 22% in seven studies with 779 participants) and one community screening study reported the predominance of concentric LVH (12%).ConclusionLeft ventricular hypertrophy is evident in at least one-fifth of children and young adults with PH and in nearly a third of those referred to specialty clinics with a predominant eccentric LVH pattern in the latter. Increased BMI is the most significant risk association for LVH in hypertensive youth.
The effectiveness of video animations as information tools for patients and the general public: A systematic review
Authors: Moe-Byrne Thirimon , Evans Ella , Benhebil Nadia , Knapp Peter 
Published: October 2022

Background and objectivesVideo animations are used increasingly as patient information tools; however, we do not know their value compared to other formats of delivery, such as printed materials, verbal consultations or static images.MethodsThis review compares the effectiveness of video animations as information tools vs. other formats of delivery on patient knowledge, attitudes and cognitions, and behaviours. Included studies had the following features: controlled design with random or quasi-random allocation; patients being informed about any health condition or members of the public being informed about a public health topic; comparing video animation with another delivery format. Multiple digital databases were searched from 1996-June 2021. We also undertook citation searching. We used dual, independent decision-making for inclusion assessment, data extraction and quality appraisal. Included studies were appraised using the Cochrane ROB2 tool. Findings were reported using narrative synthesis.ResultsWe included 38 trials, focussed on: explaining medical or surgical procedures (n = 17); management of long-term conditions (n = 11); public health, health-promotion or illness-prevention (n = 10). Studies evaluated cartoon animations (n = 29), 3D animations (n = 6), or 2D animations, “white-board” animations or avatars (n = 1 each). Knowledge was assessed in 30 studies, showing greater knowledge from animations in 19 studies, compared to a range of comparators. Attitudes and cognitions were assessed in 21 studies, and animations resulted in positive outcomes in six studies, null effects in 14 studies, and less positive outcomes than standard care in one study. Patient behaviours were assessed in nine studies, with animations resulting in positive outcomes in four and null effects in the remainder. Overall risk of bias was “high” (n = 18), “some concerns” (n = 16) or “low” (n = 4). Common reasons for increased risk of bias were randomisation processes, small sample size or lack of sample size calculation, missing outcome data, and lack of protocol publication.DiscussionThe overall evidence base is highly variable, with mostly small trials. Video animations show promise as patient information tools, particularly for effects on knowledge, but further evaluation is needed in higher quality studies.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?, identifier: CRD42021236296.
De-novo genome assembly and annotation of sobaity seabream Sparidentex hasta
Authors: Karam Qusaie , Kumar Vinod , Shajan Anisha B. , Al-Nuaimi Sabeeka , Sattari Zainab , El-Dakour Saleem 
Published: October 2022

Sparidentexhasta (Valenciennes, 1830) of the Sparidae family, is an economically important fish species. However, the genomic studies on S. hasta are limited due to the absence of its complete genome. The goal of the current study was to sequence, assemble, and annotate the genome of S. hasta that will fuel further research related to this seabream. The assembled draft genome of S. hasta was 686 Mb with an N50 of 80 Kb. The draft genome contained approximately 22% repeats, and 41,201 genes coding for 44,555 transcripts. Furthermore, the assessment of the assembly completeness was estimated based on the detection of ∼93% BUSCOs at the protein level and alignment of &gt;99% of the filtered reads to the assembled genome. Around 68% of the predicted proteins (n = 30,545) had significant BLAST matches, and 30,473 and 13,244 sequences were mapped to Gene Ontology annotations and different enzyme classes, respectively. The comparative genomics analysis indicated S. hasta to be closely related to Acanthopagrus latus. The current assembly provides a solid foundation for future population and conservation studies of S. hasta as well as for investigations of environmental adaptation in Sparidae family of fishes. Value of the Data: This draft genome of S. hasta would be very applicable for molecular characterization, gene expression studies, and to address various problems associated with pathogen-associated immune response, climate adaptability, and comparative genomics. The accessibility of the draft genome sequence would be useful in understanding the pathways and functions at the molecular level, which may further help in improving the economic value and their conservation.
Humoral and cellular immunogenicity of COVID-19 booster dose vaccination in inflammatory arthritis patients
Authors: Wroński Jakub , Jaszczyk Bożena , Roszkowski Leszek , Felis-Giemza Anna , Bonek Krzysztof , Kornatka Anna , Plebańczyk Magdalena , Burakowski Tomasz , Lisowska Barbara , Kwiatkowska Brygida , Maśliński Włodzimierz , Wisłowska Małgorzata , Massalska Magdalena , Ciechomska Marzena , Kuca-Warnawin Ewa 
Published: October 2022

IntroductionPrevious studies have shown a reduction in the effectiveness of primary COVID-19 vaccination in patients with rheumatic diseases. However, limited data is available regarding the effectiveness of the COVID-19 vaccine booster dose, especially on cellular response. The study aimed to assess the humoral and cellular immunogenicity of a booster dose in patients with inflammatory arthritis (IA).Patients and methods49 IA and 47 age and sex-matched healthy controls (HC) were included in a prospective cohort study. Both groups completed primary COVID-19 vaccination and after more than 180 days received a BNT162b2 booster shot. Humoral responses (level of IgG antibodies) and cellular responses (IFN-γ production) were assessed before and after 4 weeks from the booster dose of the vaccine.ResultsAfter the booster dose, all participants showed an increased humoral response, although significantly reduced antibody levels were observed in IA patients compared to HC (p=0.004). The cellular response was significantly lower both before (p&lt;0.001) and after (p&lt;0.001) the booster dose in IA patients as compared to HC. Among the immunomodulatory drugs, only biological and targeted synthetic drugs lowered the humoral response after booster vaccination. However, the cellular response was decreased after all immunomodulatory drugs except IL-17 inhibitors and sulfasalazine.ConclusionOur data indicate that patients with rheumatic diseases present lower humoral and cellular responses after the COVID-19 booster vaccine in comparison to HC. This may translate into a recommendation for subsequent booster doses of the COVID-19 vaccine for rheumatic patients.