bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zengî Atabeyliği ve Kudüs Haçlı Krallığı’nın Mısır Üzerinde Hâkimiyet Mücadelesi
Authors: MOLLAİBRAHİMOĞLU Mustafa , ARSLAN İhsan 
Published: June 2022

Öz: Haçlı Seferleri ilk olarak Filistin merkezli olmak üzere Doğu Akdeniz’de cereyan etmiştir. Ancak II. Haçlı Seferi’nin başarısızlığa uğraması ve Suriye ve çevresinde Zengî hâkimiyetinin güçlenmesiyle Haçlılar Mısır’a yönelmişlerdir. Filistin ve Suriye’de siyasî durumun Haçlılar aleyhine değişmesinin yanında Mısır’da hüküm süren Fâtımî Halifeliği’nin son derece karmaşık bir sürece girmesi de Kudüs Haçlı Krallığı için bölgeyi daha cazip hale getirmişti. Bunun yanında, Fâtımîlerin devrik veziri Şâver b. Mücîr’in yardım talebi sebebiyle Zengî Atabeyliği bu bölgede tasarrufta bulunma imkânı elde etmiştir.
Bu çalışmada, Fâtımî Halifeliği’nin içinde bulunduğu siyasî krizden başlayarak Haçlılar’ın Askalân’ı zaptı incelenecektir. Ayrıca Zengîler’le Kudüs Haçlı Krallığı arasında yaklaşık on yıllık bir dönemi kapsayan Mısır’da hâkimiyet kurma mücadelesi ele alınacaktır.
Colchicine as A Potential Therapy in Hepatocellular Carcinoma: A Review
Authors: Mahardhika Gembong Satria , Ilmi Azizah Nurul , Arinton I Gede , Suharno Suharno 
Published: June 2022

Background: Liver cancer is the seventh most common cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is a challenging disease to treat and has a poor prognosis. Colchicine is an old drug that was recently found to have anticancer activities towards several cancer cells. This article aimed to review the potential properties of colchicine as chemotherapy for HCC.Methods: The literature review was done by searching databases from PubMed, Cochrane, and ProQuest from June 4th to 26th, 2021. Full-text articles were searched by literature search strategies. The articles were screened by abstract and title. Studies that met the criteria were screened for full text.Results: Forty-six articles were identified, seven articles were screened for titles and abstracts, and three articles were excluded owing to full-text unavailability. Four articles were reviewed.Conclusions: The potential of colchicine as a preventive therapy in HCC needs to be further explored, and additional tests need to be done, especially in vivo. Larger population studies should also be done to evaluate the safety, usefulness, and feasibility of colchicine, especially in HCC.
Predicting Normal Tissue Radiotoxicity in Radiotherapy Patients Based on the Individual Radiosensitivity Using Three-Color Fluorescence In Situ Hybridization: A Literature Review
Authors: Ramadhani Dwi , Farida Isnaini , Wulansari Arum , Mailana Wiwin , Ru’yi Hartini Ahadiyatur , Ulya Syarifatul , Purnami Sofiati , Rahajeng Nastiti , Tetriana Devita , Kurnia Iin , Syaifudin Mukh 
Published: June 2022

Background: The variability of clinical response in radiotherapy (RT) patients revealed that individual radiosensitivity exists in humans. Although several techniques for radiosensitivity assessment are available, fluorescence in situ hybridization (FISH) has proven to be the most reliable cytogenetic technique. This study will review the use of three-color FISH to evaluate the individual radiosensitivity in cancer patients, particularly breast and prostate cancer patients. Also, it will explain factors that should be considered when using this assay in RT patients.Methods: We used the “radiosensitivity”, “fluorescence in situ hybridization”, “FISH”, and “cancer” as medical subject headings. Non-English articles were excluded. Only articles written in English with a full-text PDF format could be found and using three-color FISH for individual radiosensitivity prediction in radiotherapy patients as subjects were included in this review.Results: : In total, 1,905 articles were retrieved from PubMed and PubMed Central databases from 1990 to 2020. The articles were screened, and those that met the inclusion criteria and did not meet the exclusion criteria were reviewed. Finally, we evaluated eight articles in this reviewConclusions: Appropriate assays such as three-color FISH for individual radiosensitivity assessment could optimize the effectiveness of RT treatment and predict the severity of normal tissue toxicity reactions in RT patients.
The Association of Programmed Death Ligand 1 (PD-L1) and Cluster of Differentiation 95 Ligand (CD95L) Immunoexpression with Chemotherapy Response in Classical Hodgkin Lymphoma
Authors: Agustina Hasrayati , Aryanti Aryanti , Hernowo Bethy Suryawathy 
Published: June 2022

Background: Programmed Death Ligand (PD-L1) and Cluster of Differentiation 95 (CD95L) are influenced by oncogenes and function in the anti-apoptosis process which is thought to play a role in chemotherapy resistance. This study aimed to analyze the association of PD-L1 and CD95L immunoexpression with chemotherapy response in Classical Hodgkin Lymphoma (CHL).Method: This study involved 40 cases of histopathologically diagnosed CHL treated with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. PD-L1 and CD95L immunohistochemical staining were performed in selected paraffin-embedded tissue blocks of all cases. The chemotherapy response status of the patients was taken from the medical recordResults: High PDL-1 immunoexpression was evident in 19 (47.5%) cases while positive CD95L immunoexpression was found in 14 (35%) CHL cases. High PD-L1 immunoexpression was significantly associated with the Non-Responsive (NR) group (78.9%) with p-value = 0.0001. Positive CD95L immunoexpression was greater in the NR group (71.4%) with p-value = 0.37.Conclusion: : High PD-L1 immunoexpression indicated an unfavorable response to ABVD chemotherapy in CHL. CD95L immunoexpression was not associated with ABVD chemotherapy response in CHL.
Association of Vascular Endothelial Growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) with Radiotherapy Response in High-Grade Sarcomas
Authors: Soesilowati Eny , Afiati Afiati , Yulianti Herry , Hernowo Bethy Suryawathy , Kusumadjati Adji 
Published: June 2022

Background: Sarcoma is a rare malignant aggressive tumor originating from mesenchymal elements. High-grade sarcoma has a poor prognosis. The mortality rate of high-grade sarcomas is 50–75%. Radiotherapy is needed in high-grade sarcoma. Radioresistance in the high-grade sarcoma is still common. Vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) are molecular markers that play a role in radioresistance. This study aimed to analyze the association of VEGF and mTOR with radiotherapy response in high-grade sarcoma. Method: This study was an analytic observational study with a cross-sectional design. The minimum samples based on Lameshow’s formula included 40 selected paraffin-embedded tissue blocks from biopsy high-grade sarcoma, consisting of 20 samples of radioresistance and 20 samples of radiosensitive. Immunohistochemistry staining for VEGF and mTOR were performed on all samples. Statistical analysis used the Chi-Square test. The significance of the data was obtained when p-value <0.05.Result: High immunoexpression of VEGF (OR = 17, p < 0.05) and mTOR in high-grade sarcoma showed a significant association with radiotherapy response (OR = 16, p < 0.05). The stepwise logistic regression analysis revealed that both VEGF and mTOR immunoexpression influenced radiotherapy response simultaneously. Conclusion: In this study, which used a minimum sample, it can be concluded that the higher VEGF and mTOR immunoexpression showed the higher radioresistance in high-grade sarcoma.
Transcatheter Arterial Chemo Infusion/TACI for Breast Cancer Treatment: A Case Series
Authors: Poedjomartono Bagaswoto , Bangun Alan Anderson , Bachtiar Rifki 
Published: June 2022

Introduction: Locally advanced breast cancer (LABC) is a large breast tumor with infiltration to surrounding muscle, skin, and lymph nodes, and sometimes followed by inflammatory breast cancer, a rapidly growing cancer that shows a swollen red lump on the skin. Transcatheter intraarterial chemo infusion (TACI) is considered a palliative therapy for inoperable cancer. This case report shows the qualitative results of TACI on LABC in three patients. Case Presentation: Three female patients with LABC were diagnosed and treated at Dr. Sardjito General Hospital Yogyakarta over three years (2014–2016). The age ranged from 48 to 62 years, with a mean age of 56 years. Clinical features include lumps in breasts, soft tissue swelling, ulcers, dimpling of breast skin, nipple discharge, and pain sensation in the breast area. The three patients underwent the TACI procedure. Therapeutic response was evaluated by observing the clinical morphology of the lesions. Conclusions: TACI showed potency as an efficient and effective alternative palliative therapy in the three LABC cases presented. However, further study is needed to inspect TACI’s efficacy and adverse effects in breast cancer cases to be used as evidence-based medicine.
Avaliação da qualidade do sono e seus distúrbios em estudantes da Universidade Estadual de Mato Grosso do Sul
Authors: Souza Pedro Henrique de , Oliveira Cecília Rezende de Almeida , Cespedes Mateus da Silveira , Leite Lucas Rasi Cunha , Guenka Leandro Caetano , Souza José Carlos 
Published: June 2022

Objetivo: Avaliar os hábitos e distúrbios do sono entre os estudantes de diferentes cursos de graduação da Universidade Estadual de Mato Grosso do Sul (UEMS), através da aplicação dos instrumentos PSQI e ESE, correlacionando com dados sociodemográficos dos discentes. Metodologia: O presente estudo se deu de forma quantitativa, observacional, transversal e descritivo, com análise situacional de 110 acadêmicos dos cursos de Teatro, Turismo, Artes Cênicas, Dança e Pedagogia, através de questionários aplicados (sociodemográfico, PSQI e Escala de Sonolência de Epworth). Os dados obtidos foram tabulados e processados por meio do software IBM SPSS Statistics, sendo apresentados nas formas de frequências relativa e absoluta. Resultados: Dos 110 acadêmicos, 16 aceitaram participar da pesquisa e preencheram adequadamente os questionários. Do total de participantes, 81,25% (n=13) eram do sexo feminino. 31,25% (n=5) eram do curso de teatro, 31,25% (n=5) eram do curso de turismo, 25% (n=4) eram do curso de artes cênicas, 6,25% (n=1) era do curso de dança e 6,25% (n=1) era do curso de pedagogia. 62,5% (n=10) dos participantes apresentaram má qualidade do sono, com pontuação do PSQI maior do que 5. A avaliação do nível de sonolência diurna excessiva segundo a ESE (Escala de Sonolência de Epworth) indicou que 31,25% (n=5) dos discentes apresentaram sonolência excessiva diurna e 68,75% (n=11) não apresentaram distúrbios. Conclusão: Foi observado que grande parte dos discentes apresentaram má qualidade do sono e boa parte apresentou sonolência excessiva diurna, interferindo diretamente no desempenho acadêmico dos estudantes.
A ingestão de cafeína como fator protetor no desenvolvimento e na progressão da Doença de Parkinson e na Doença de Alzheimer: uma revisão integrativa
Authors: Paiva Tatiana Lima , Santos Giovanni Ferreira , Coutinho João Otávio Bayão , Mendonça Mariana Moreira Munhoz , Dutra Dalbert Samuel , Leite Jorge Antonio de Moura , Rigueira José Marcos Leite , Mazzieiro Giulia Pieroli , Ferreira Louvana Cristelle Camargos , Araújo Bethânia Cristhine de 
Published: June 2022

Introdução: A prevalência da Doença de Alzheimer (DA) e da Doença de Parkinson (DP), tende a aumentar com o envelhecimento populacional. Até o momento, os esquemas terapêuticos para essas doenças não consegue alcançar a cura e geralmente não são atualizados, o que evidencia a necessidade de outras opções para a melhora da qualidade de vida desses pacientes. Dado que essas síndromes demenciais tem etiologia multifatorial, a dieta, por meio do café, tem mostrado evidências significativas na degeneração neuronal, que é um dos principais aspectos alterados no desenvolvimento dessas patologias. Metodologia: Trata-se de uma revisão integrativa, que buscou responder quais os possíveis efeitos da cafeína como fator protetor no desenvolvimento e na progressão da revisional e da DP, nas bases de dados: Biblioteca Virtual de Saúde (BVS), National Library of Medicine (PubMed MEDLINE) e Scientific Electronic Library Online (Scielo). Resultados e Discussão: A cafeína age no sistema nervoso central (SNC) pela mimetização aos receptores de adenosina, mais concentrada nos receptores A1R e A2aR. Como antagonista competitivo, a cafeína, eventualmente, poderia reduz os processos de formação das placas b-amiloides na DA e reduzir a neuroinflamação e neurodegeneração na DP, além de outros possíveis mecanismos. Conclusão: A delimitação de um consenso sobre a relação dose/efeito decorrente do uso da cafeína é de difícil estabelecimento e ainda não se observa um consenso, entretanto, é possível observar que um consumo entre 200mg a 511mg por dia poderia trazer efeitos benéficos tanto na DP, como na DA, superando os possíveis efeitos colaterais.
TINGGALAN KOLONIAL JEPANG DI DESA TANGGETADA KECAMATAN TANGGETADA KABUPATEN KOLAKA PROVINSI SULAWESI TENGGARA
Authors: Saputra Kadek Dwi , Aswati ASwati , Hayunira Sasadara 
Published: June 2022

Desa Tanggetada merupakan tempat ditemukannya tinggalan arkeologis yang berupa sisa-sisa bangunan Perang Dunia II yang dibangun Jepang pada masa Perang Dunia II atau Perang Pasifik. Masalah yang diangkat dalam penelitian ini adalah:( 1) Apa saja tinggalan Kolonial Jepang yang terdapat di Desa Tanggetada Kecamtan Tanggetada Kabupaten Kolaka. (2) Bagaimana fungsi tinggalan Kolonial Jepang yang terdapat di Desa Tanggetada Kecamatan Tanggetada Kabupaten Kolaka. Penelitian ini bertujuan untuk mengetahui tinggalan-tinggalan apa saja yang ada dan bagaimana fungsi tinggalan Pendudukan Jepang yang ada di lokasi Desa Tanggetada Kecamatan Tanggetada. Dalam penelitian yang dilakukan ini memakai teori arkeologi keruangan. Hasil penelitian ini menunjukkan bahwa tinggalan Pendudukan Jepang di Situs Desa Tanggetada terdiri atas Bunker berjumlah 4 buah, Revetment berjumlah 4 buah, Tungku berjumlah 1 buah, Sumur berjumlah 1 buah, Pertahanan darat pinggir pantai berjumlah 1 buah. Adapun bunker berfungsi sebagai sarana perlindungan ketika dalam situasi berperang. Revetment pesawat berperan sebagai tempat parkir pesawat sekaligus sebagai pelindung tubuh pesawat dari ledakan bom. Struktur tungku pada penelitian ini berfungsi sebagai sarana untuk memasak makanan dan minuman untuk kebutuhan hidup sehari-hari pasukan Jepang. Sumur berfungsi sebagai tempat pengambilan air, untuk kebutuhan seperti air minum dan mandi pasukan Jepang. Pertahanan darat sepanjang pantai ini berfungsi sebagai pertahanan penyerangan musuh dari laut.
IDENTIFIKASI TINGGALAN KOLONIAL JEPANG DI KECAMATAN SOROPIA, KABUPATEN KONAWE
Authors: Maya Nafsia Eva , Kasmiati Sitti 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui jenis tinggalan kolonial Jepang dan fungsi berdasarkan bentuk tinggalan kolonial Jepang. Penelitian ini menggunakan teori arkeologi sejarah budaya. Penelitian ini menggunakan metode pengumpulan data berupa studi pustaka yaitu mengumpulkan literatur yang berhubungan dengan judul penelitian, observasi lapangan yaitu survei permukaan dan perekaman data dan wawancara. Kemudian tahap pengolahan data dan analisis data yaitu menggunakan analisis morfologi.
Hasil penelitian menunjukkan bahwa tinggalan yang ditemukan secara keseluruhan berjumlah 9 yakni: bangunan bersekat, struktur oktagon (segi delapan), struktur bak penampungan air, struktur bangunan berbentuk U dan temuan lepas berupa fragmen botol kaca. Temuan lepas menjadi data pendukung tinggalan bangunan. Fungsi dari masing-masing tinggalan yaitu: bangunan bersekat berfungsi sebagai barak atau camp tempat tinggal. Struktur oktagon (segi delapan) berfungsi sebagai radar.Struktur bak air berfungsi sebagai bak penyaring dan penampung air bersihyang digunakan untuk keperluan sehari-hari. Struktur berbentuk U berfungsi sebagai dudukan mesin air.
Beneficial Modulatory Effects of Treatment With Bone Marrow Lysate on Hematopoietic Stem Cells and Myeloid Cells in Tumor-Bearing Mice
Authors: Salem Mohamed L. , El-Bakry Kadry A. , Moubark Eman H. , Sobh Ashraf , Khalil Sohaila M. 
Published: June 2022

Introduction:Leukopenia is one of the major side effects of myelosuppressive chemotherapy such as cyclophosphamide (CTX). We and others have used CTX either alone or in combination with G-CSF for the mobilization of hematopoietic stem cells (HSCs). This mobilization can induce expansion of myeloid cells with immunosuppressive phenotype. In this pilot study, we aimed to test whether bone marrow lysate (BML)/CTX, a rich source of growth factors, can lower the expansion of myeloid cells with immunosuppressive phenotypes in tumor-bearing mice without interfering with the anti-tumor effects of CTX or with the mobilization of HSCs.Methods:Female CD1 mice were treated on day 0 with an i.p. injection of Ehrlich ascites carcinoma (EAC). On day 7, the mice were i.p. injected with CTX followed by s.c. injection of G-CSF for 5 consecutive days, single s.c. injection of BML/PBS or BML/CTX or single i.v. injection of BMC/PBS or BMC/CTX.Results:Treatment of EAC-bearing mice with BML/PBS or BML/CTX did not interfere with the anti-tumor effect of CTX. EAC increased the numbers of immature polymorphonuclear cells (iPMN; neutrophils) in both blood and spleen. Treatment of EAC-bearing mice with CTX further increased the numbers of these cells, which were decreased upon treatment with BML/CTX. Treatment with BML/PBS or BML/CTX increased the numbers of stem cells (C.Kit+Sca-1+) in BM; the effect of BML/CTX was higher, but with no significant effect on the numbers of HSCs. Future studies are needed to analyze the molecular components in BM lysate and to determine the underlying mechanisms.
Performance of Machine Learning Algorithms for Predicting Adverse Outcomes in Community-Acquired Pneumonia
Authors: Xu Zhixiao , Guo Kun , Chu Weiwei , Lou Jingwen , Chen Chengshui 
Published: June 2022

Background: The ability to assess adverse outcomes in patients with community-acquired pneumonia (CAP) could improve clinical decision-making to enhance clinical practice, but the studies remain insufficient, and similarly, few machine learning (ML) models have been developed.Objective: We aimed to explore the effectiveness of predicting adverse outcomes in CAP through ML models.Methods: A total of 2,302 adults with CAP who were prospectively recruited between January 2012 and March 2015 across three cities in South America were extracted from DryadData. After a 70:30 training set: test set split of the data, nine ML algorithms were executed and their diagnostic accuracy was measured mainly by the area under the curve (AUC). The nine ML algorithms included decision trees, random forests, extreme gradient boosting (XGBoost), support vector machines, Naïve Bayes, K-nearest neighbors, ridge regression, logistic regression without regularization, and neural networks. The adverse outcomes included hospital admission, mortality, ICU admission, and one-year post-enrollment status.Results: The XGBoost algorithm had the best performance in predicting hospital admission. Its AUC reached 0.921, and accuracy, precision, recall, and F1-score were better than those of other models. In the prediction of ICU admission, a model trained with the XGBoost algorithm showed the best performance with AUC 0.801. XGBoost algorithm also did a good job at predicting one-year post-enrollment status. The results of AUC, accuracy, precision, recall, and F1-score indicated the algorithm had high accuracy and precision. In addition, the best performance was seen by the neural network algorithm when predicting death (AUC 0.831).Conclusions: ML algorithms, particularly the XGBoost algorithm, were feasible and effective in predicting adverse outcomes of CAP patients. The ML models based on available common clinical features had great potential to guide individual treatment and subsequent clinical decisions.
Oral-Gut Microbiome Analysis in Patients With Metabolic-Associated Fatty Liver Disease Having Different Tongue Image Feature
Authors: Lu Chenxia , Zhu Hui , Zhao Dan , Zhang Jia , Yang Kai , Lv Yi , Peng Miao , Xu Xi , Huang Jingjing , Shao Zuoyu , Xiao Mingzhong , Li Xiaodong 
Published: June 2022

ObjectiveThe objective of this study was to identify the biological correlation between the tongue coating color and oral and gut micro-characteristics in metabolic-associated fatty liver disease (MAFLD) patients.MethodThe characteristics of the tongue coating were examined using an automatic tongue diagnosis system. Tongue coating and stool samples were collected from 38 MAFLD patients, and 16S rDNA full-length assembly sequencing technology (16S-FAST) was used for bioinformatic analysis.ResultsTwenty-two and 16 subjects were included in two distinct clusters according to the white/yellow color of the tongue coating, which was assessed by the L*a*b* values of the image. Upon analyzing the microorganisms in the tongue coating, 66 and 62 pathognomonic bacterial genera were found in the White and Yellow Coating Groups, respectively. The abundance of Stomatobaculumis positively correlated with the a* values of the tongue coating in the White Coating Group, while Fusobacterium, Leptotrichia, and Tannerella abundance was significantly correlated with the b* values in the Yellow Coating Group. Function prediction mainly showed the involvement of protein families related to BRITE hierarchies and metabolism. The MHR (MONO%/high-density lipoprotein cholesterol) of the Yellow Coating Group was higher than that of the White Coating Group.ConclusionIn MAFLD patients, lower a* values and higher b* values are indicators of a yellow tongue coating. There were also significant differences in the flora of different tongue coatings, with corresponding changes in the intestinal flora, indicating a correlation between carbohydrate metabolism disorders and inflammation in the oral microbiome.
Increasing Adiposity Is Associated With QTc Interval Prolongation and Increased Ventricular Arrhythmic Risk in the Context of Metabolic Dysfunction: Results From the UK Biobank
Authors: Patel Kiran Haresh Kumar , Li Xinyang , Xu Xiao , Sun Lin , Ardissino Maddalena , Punjabi Prakash P. , Purkayastha Sanjay , Peters Nicholas S. , Ware James S. , Ng Fu Siong 
Published: June 2022

BackgroundSmall-scale studies have linked obesity (Ob) and metabolic ill-health with proarrhythmic repolarisation abnormalities. Whether these are observed at a population scale, modulated by individuals’ genetics, and confer higher risks of ventricular arrhythmias (VA) are not known.Methods and ResultsFirstly, using the UK Biobank, the association between adiposity and QTc interval was assessed in participants with a resting 12-lead ECG (n = 23,683), and a polygenic risk score (PRS) was developed to investigate any modulatory effect of genetics. Participants were also categorised into four phenotypes according to the presence (+) or absence (–) of Ob, and if they were metabolically unhealthy (MU+) or not (MU-). QTc was positively associated with body mass index (BMI), body fat (BF), waist:hip ratio (WHR), and hip and waist girths. Individuals’ genetics had no significant modulatory effect on QTc-prolonging effects of increasing adiposity. QTc interval was comparably longer in those with metabolic perturbation without obesity (Ob-MU+) and obesity alone (Ob+MU-) compared with individuals with neither (Ob-MU-), and their co-existence (Ob+MU+) had an additive effect on QTc interval. Secondly, for 502,536 participants in the UK Biobank, odds ratios (ORs) for VA were computed for the four clinical phenotypes above using their past medical records. Referenced to Ob-MU-, ORs for VA in Ob-MU+ men and women were 5.96 (95% CI: 4.70–7.55) and 5.10 (95% CI: 3.34–7.80), respectively. ORs for Ob+MU+ were 6.99 (95% CI: 5.72–8.54) and 3.56 (95% CI: 2.66–4.77) in men and women, respectively.ConclusionAdiposity and metabolic perturbation increase QTc to a similar degree, and their co-existence exerts an additive effect. These effects are not modulated by individuals’ genetics. Metabolic ill-health is associated with a higher OR for VA than obesity.