bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases
Authors: Karaky Mohamad , Boucher Gabrielle , Mola Saraï , Foisy Sylvain , Beauchamp Claudine , Rivard Marie-Eve , Burnette Melanie , Gosselin Hugues ,   iGenoMed Consortium, Bitton Alain , Charron Guy , Goyette Philippe , Rioux John D. 
Published: September 2022

Background
Genome wide association studies (GWAS) have identified and validated more than 200 genomic loci associated with the inflammatory bowel disease (IBD), although for most the causal gene remains unknown. Given the importance of myeloid cells in IBD pathogenesis, the current study aimed to uncover the role of genes within IBD genetic loci that are endogenously expressed in this cell lineage.

Methods
The open reading frames (ORF) of 42 genes from IBD-associated loci were expressed via lentiviral transfer in the THP-1 model of human monocytes and the impact of each of these on the cell’s transcriptome was analyzed using a RNA sequencing-based approach. We used a combination of genetic and pharmacologic approaches to validate our findings in the THP-1 line with further validation in human induced pluripotent stem cell (hiPSC)-derived-monocytes.

Results
This functional genomics screen provided evidence that genes in four IBD GWAS loci (PTGIR, ZBTB40, SLC39A11 and NFKB1) are involved in controlling S100A8 and S100A9 gene expression, which encode the two subunits of calprotectin (CP). We demonstrated that increasing PTGIR expression and/or stimulating PTGIR signaling resulted in increased CP expression in THP-1.
This was further validated in hiPSC-derived monocytes. Conversely, knocking-down PTGIR endogenous expression and/or inhibiting PTGIR signaling led to decreased CP expression. These analyses were extended to the known IBD gene PTGER4, whereby its specific agonist also led to increased CP expression. Furthermore, we demonstrated that the PTGIR and PTGER4 mediated control of CP expression was dependent on signaling via adenylate cyclase and STAT3. Finally, we demonstrated that LPS-mediated increases in CP expression could be potentiated by agonists of PTGIR and PTGER4, and diminished by their antagonists.

Conclusion
Our results support a causal role for the PTGIR, PTGER4, ZBTB40, SLC39A11 and NFKB1 genes in IBD, with all five genes regulating the expression of CP in myeloid cells, as well as potential roles for the prostacyclin/prostaglandin biogenesis and signaling pathways in IBD susceptibility and pathogenesis.
Latent classes of men’s intimate partner violence perpetration and attitudes towards gender norms: A UN multi-country, cross-sectional study in Asia and the Pacific
Authors: Willie Tiara C. , Katague Marina , Halim Nafisa , Gupta Jhumka 
Published: September 2022

Objective
To examine distinct patterns of IPV perpetration and examined gender equitable attitudes as a correlate of these patterns among men from six countries in Asia and the Pacific.

Design
2011–12 UN Multi-country Study on Men and Violence cross-sectional study.

Setting
Households in Bangladesh, Cambodia, China, Indonesia, Sri Lanka and Papua New Guinea.

Participants
10,178 men aged 18–49 years residing in Bangladesh, Cambodia, China, Indonesia, Sri Lanka and Papua New Guinea.

Primary outcomes measure
Our primary outcome was distinct patterns of IPV perpetration which were derived from multilevel latent class analyses.

Results
The odds of being assigned to the Low All Forms of IPV Perpetration class than the High All Forms of IPV Perpetration class was lower for men in the middle tertile group than men in the high tertile group for gender equitable attitudes. The odds of being assigned to the High Emotional IPV Perpetration class than the High All Forms of IPV Perpetration class was greater for men in the low tertile group than men in the high tertile group for gender equitable attitudes. The odds of being assigned to the High Physical/Emotional/Economic IPV Perpetration class than the High All Forms of IPV Perpetration class was lower for men in the low tertile group than men in the high tertile group for gender equitable attitudes.

Conclusions
Gender transformative interventions that use an adaptive, personalized approach to men’s typology of IPV perpetration may be beneficial to reduce violence against for women in the Asia-Pacific region.
Comparative assessment of the cost-effectiveness of Tuberculosis (TB) active case-finding interventions: A systematic analysis of TB REACH wave 5 projects
Authors: Gomes Isabella , Dong Chaoran , Vandewalle Pauline , Khan Amera , Creswell Jacob , Dowdy David , Sohn Hojoon 
Published: September 2022

Purpose
Interventions that can help streamline and reduce gaps in the tuberculosis (TB) care cascade can play crucial roles in TB prevention and care, but are often operationally complex and resource intensive, given the heterogenous settings in which they are implemented. In this study, we present a comparative analysis on cost-effectiveness of TB REACH Wave 5 projects with diverse programmatic objectives to inform future decisions regarding funding, strategic adoption, and scale-up.

Methods
We comprehensively reviewed project reports and financial statements from TB REACH Wave 5, a funding mechanism for interventions that aimed to strengthen the TB care cascade in diverse settings. Two independent reviewers abstracted cost (in 2017 US dollars) and key programmatic data, including project type (case-finding only; case-finding and linkage-to-care; or case-finding, linkage-to-care and patient support), operational setting (urban or rural), and project outputs (numbers of people with TB diagnosed, started on treatment, and successfully completing treatment). Cost-effectiveness ratios for each project were calculated as ratios of apportioned programmatic expenditures to corresponding project outputs.

Results
Of 32 case finding and patient support projects funded through TB REACH Wave 5, 29 were included for analysis (11 case-finding only; 9 case-finding and linkage-to-care; and 9 case-finding, linkage-to-care and patient support). 21 projects (72%) were implemented in either Africa or Southeast Asia, and 19 (66%) focused on serving urban areas. Average cost-effectiveness was $184 per case diagnosed (range: $30-$10,497), $332 per diagnosis and treatment initiation ($123-$10,608), and $40 per patient treatment supported ($8-$160). Cost per case diagnosed was lower for case-finding-only projects ($132) than projects including linkage-to-care ($342) or linkage-to-care and patient support ($254), and generally increased with the corresponding country’s per-capita GDP ($543 per $1000 increase, 95% confidence interval: -$53, $1138).

Conclusion
The costs and cost-effectiveness of interventions to strengthen the TB care cascade were heterogenous, reflecting differences in context and programmatic objective. Nevertheless, many such interventions are likely to offer good value for money. Systematic collection and analysis of cost-effectiveness data can help improve comparability, monitoring, and evaluation.
Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study
Authors: Harrington Whitney E. , Yeung Winnie , Beck Ingrid A. , Mast Fred D. , Houck John , Styrchak Sheila , Miller Leslie R. , Li Song , Haglund Micaela , Jiang Yonghou , Armistead Blair , Wallner Jackson , Nguyen Tina , Ko Daisy , Hardy Samantha , Oldroyd Alyssa , Gervassi Ana , Aitchison John D. , Frenkel Lisa M. 
Published: September 2022

Background
Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear.

Methods
To identify SARS-CoV-2 infections 553 seronegative individuals were prospectively followed for 52 weeks. From 4/2020-7/2021, participants submitted weekly self-collected nasal swabs for rtPCR and completed symptom and exposure surveys.

Results
Incident SARS2-CoV-2 infections were identified in 9/553 (1.6%) participants. Comparisons of SARS2-CoV-2(+) to SARS2-CoV-2(-) participants revealed significantly more close contacts outside the household (median: 5 versus 3; p = 0.005). The incidence of infection was higher among unvaccinated/partially vaccinated than among fully vaccinated participants (9/7,679 versus 0/6,845 person-weeks; p = 0.004). At notification of positive test result, eight cases were symptomatic and one pre-symptomatic.

Conclusions
These data suggest that weekly SARS2-CoV2 surveillance by rtPCR did not efficiently detect pre-symptomatic infections in unvaccinated participants.
The presence of spin in systematic reviews focused on diabetic neuropathy: A cross-sectional analysis
Authors: Khan Ali , Riley Haley , Ottwell Ryan , Arthur Wade , Greiner Benjamin , Shapiro Ekaterina , Wright Drew , Hartwell Micah , Chen Suhao , Miao Zhuqi , Chronister Stacy , Vassar Matt 
Published: September 2022

Background
Spin—the misrepresentation of a study’s actual results—has the potential to alter a clinician’s interpretation of the study’s findings and therefore could affect patient care. Studies have shown spin frequently occurs in abstracts of systematic reviews from a variety of other medical disorders and specialties.

Aims
Our primary aim was to evaluate whether the nine most severe types of spin occurred in systematic review abstracts’ concerning diabetic neuropathy treatments. Secondly, we aimed to determine whether spin presence was associated with the methodological quality of a systematic review.

Methods
A search of MEDLINE and Embase collected 1297 articles focused on diabetic neuropathy treatments, of which we included 114 systematic reviews for spin assessment. Each included study was evaluated for the nine most severe types of spin as defined by Yachitz et al. The methodological quality of a systematic review was determined by using the AMSTAR-2 instrument. All screening and data extraction were conducted in a masked, duplicate fashion. Since the final sample size of 114 was not sufficiently powered to do multivariable logistic regression, we calculated unadjusted odds ratios which evaluated relationships between spin presence within abstracts and study characteristics.

Results
From the 114 articles reviewed, spin was present in 7.9% of the studies (9/114), with spin type 5: “conclusion claims the beneficial effect of the experimental treatment despite the high risk of bias in the included primary studies” as the most frequent in our study. Spin types 1, 2, 6, and 8 were not identified. No association was observed between the study characteristics and spin presence, including the methodological quality of a systematic review.

Conclusions
Overall, spin is infrequently observed in abstracts of systematic reviews covering diabetic neuropathy treatments. When comparing our results to other fields of medicine, the field of diabetic neuropathy research publishes systematic reviews whose abstracts mostly portray the findings of the review’s full-text to reflect the results adequately.
Comparing the long non-coding RNA expression profiles of skeletal muscle and kidney tissues from patients with diabetes
Authors: Kim Young-Kook 
Published: September 2022

Background
Diabetes causes the dysregulation of several organs, and these effects are often closely associated with changes in the expression of long non-coding RNAs (lncRNAs), a group of non-coding RNAs, within these tissues. Previous studies have described a variety of changes in the expression profile of several lncRNAs from different organs in response to the pathogenesis of diabetes. However, none of these studies compared the expression profiles of these lncRNAs between these organs. This study was designed to identify common and specific lncRNAs involved in the progression of diabetes in the skeletal muscles and kidneys.

Methods
Publicly available RNA sequencing data of diabetic patients was obtained from the Gene Expression Omnibus database. By analyzing the expression of lncRNAs in these datasets, differentially expressed lncRNAs in each tissue between non-diabetic and diabetic patients were identified. To identify any lncRNAs changed in common in both kidney and muscle tissues, those lncRNAs that are significantly dysregulated in both datasets were selected.

Results
These evaluations identified a series of novel lncRNAs unique to each organ and several transcripts that were common to both skeletal muscle and kidney tissues in these patients. Interestingly, the genomic location of these lncRNAs suggests that they reside in close proximity to several protein-coding genes known to be related to diabetes suggesting that these lncRNAs may have a regulatory relationship with their neighboring genes.

Conclusion
These results offer valuable insights into the role of lncRNAs during the pathogenesis of diabetes.
Intention to obtain a COVID-19 vaccine among Brazilian immigrant women in the U.S.
Authors: Allen Jennifer D. , Priebe Rocha Leticia , Rose Raviv , Hoch Annmarie , Porteny Thalia , Fernandes Adriana , Galvão Heloisa 
Published: September 2022

Background
COVID-19 has disproportionately impacted low-income immigrant communities. There is concern that the current uptake of COVID-19 vaccines is suboptimal and that this may be contributing to COVID-19 inequities. However, little is known about the acceptability of COVID-19 vaccines among immigrants in the U.S. Our goal was to gauge COVID-19 vaccine intentions among Brazilian immigrant women living in the U.S.

Methods
We conducted an online survey between July and August 2020 offered in Portuguese and English languages among a convenience sample of Brazilian immigrant women ages 18 years and older. Women were recruited through online advertisements by community-based organizations and social media groups to complete a survey that assessed intention to get a COVID-19 vaccine, attitudes toward vaccines, and perceptions about the pandemic.

Results
Of the total sample (N = 353), most (70.8%) indicated they intended to get a COVID-19 vaccine. In bivariate analyses, vaccine intentions were significantly associated with perceptions about the severity of the pandemic, trusted sources of health information, and the number of years lived in the U.S. Multinomial logistic regression models revealed that those who did not intend to be vaccinated had lived a longer time in the U.S. (OR: -0.12 95% CI: -0.19, -0.05), perceived the pandemic to be a minor issue (OR: 1.52, 95% CI: 0.62, 2.42), and trusted information from social networks (OR: -1.94, 95% CI: -3.25, -0.63) or private news sources (OR: -1.71, 95% CI: -2.78, -0.63).

Conclusions
While most women reported they would get a COVID-19 vaccine, efforts to reach those who may be hesitant should target those who have lived in the U.S. for longer periods of time and do not perceive the pandemic to be a major crisis. Healthcare providers may be particularly suited to deliver this information given high levels of trust.
Effects and dose-response relationship of exercise training on cardiometabolic risk factors in children with obesity
Authors: Liu Jingxin , Zhu Lin , Chen Zekai , Liao Jing , Liu Xiaoguang 
Published: September 2022

Abstract

Objectives
To explore the dose-response relationship between physical activity and the improvement of cardiometabolic risks in children with obesity, and provide a reference for the recommendation of physical activity for obese children.

Methods
A total of 96 children with obesity were recruited to participate in an exercise intervention program. An ActiGraph GT3X+ three-axis accelerometer was used to measure their physical activity. The dose groups (Q1∼Q4) were divided based on the quartiles of physical activity. The analysis of variance was used to compare the changes in body composition and cardiometabolic risk factors before and after the intervention.

Results
All intervention groups showed a significant reduction in weight, body mass index, body fat percent, fat mass, fat free mass, and skeletal muscle mass (p<0.01), and the change in the Q4 and Q3 groups was greater than in the Q2 and Q1 groups. Triglyceride, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were significantly reduced after intervention in all groups (p<0.01), and the change in SBP, and DBP in the Q4 group was higher than in the Q1 group (p<0.05).

Conclusions
Exercise interventions could effectively improve body composition and cardiometabolic risk factors. A higher exercise dose is associated with significant improvements in body composition, and cardiometabolic health.
Segmentation of gastronomic consumers following Instagram influencers based on destination preferences and the effect of Covid-19 on their consumption
Authors: Szakály Orsolya 
Published: September 2022

THE AIM OF THE PAPER
The aim of the study is to explore the impact of gastronomic influencers on Instagram on consumer decision before choosing a restaurant. It also examines the role of the characteristics of destination in consumer decision-making process. The article also highlights the impact of the Covid-19 Pandemic and its impact on consumers’ decision process in that context.
METHODOLOGY
In order to analyze the main research questions, a quantative survey with 329 valid responses was implemented and descriptive statistics, relationship analysis methods and linear regression were used to answer the research questions. The research question also required the use of a subsample (n=185) in which respondents who are willing to travel for gastronomic purposes were examined during the Pandemic.
MOST IMPORTANT RESULTS
According to the results, the collection of information from gastronomic influencers on the Instagram interface is popular among the respondents, and the influencers’ activity has a positive effect on the number of visitors to the destinations. Thus, it can be said that the relationship between the influencer and the destination is characterized by a significant, medium strength relationship. Furthermore, the results also revealed that the Pandemic has led to an increase in consumers’ intentions to consume in restaurants.
RECOMMENDATIONS
As social media plays an increasingly important role in the decision-making process, it is important that professionals, service providers and researchers explore the views of consumers in the context under study. The results are highlighted in terms of destination development and in terms of consumer behavior.
Az imposztor szindróma munkaerő-piaci relevanciája
Authors: Ásványi Zsófia , Barakonyi Eszter , Riedelmayer Bernadett 
Published: September 2022

A TANULMÁNY CÉLJA
A pszichológiában az imposztor szindróma egy kognitív torzulás, mely megakadályozza, hogy az egyén megélje a munkateljesítményéhez kapcsolódó sikerélményt. Az állapotot először 1978-ban azonosították Paulin Rose Clance és Suzanne Imes pszichológusok, akik kezdetben úgy gondolták, hogy ez főként egy nőket érintő jelenség. A későbbiekben végzett kutatások eredménye szerint viszont az imposztor-szindróma a munkavállalók mintegy 70 százalékát érinti a pályafutása során. Tanulmányunkban arra keressük a választ, hogy a jelenség a megkérdezett munkavállalók körében mennyire elterjedt, kiket érint és nem utolsó sorban, hogy milyen hatással van az egyén munkateljesítményére, előmenetelére. Szintén fontos célkitűzése a kutatásnak, hogy felmérjük mennyire hátráltató, vagy éppenséggel motiváló a szindróma hatása az egyéni munkateljesítményre.
ALKALMAZOTT MÓDSZERTAN
Kutatásunk alapját egy 2022. márciusban végzett kérdőíves felmérés adta, amelyet magyar munkavállalók körében végeztünk. A kérdőívben megvizsgáltuk az imposztor szindróma nem, életkor és végzettségi szint alapján történő előfordulását a kitöltők körében. A kutatásban továbbá azt is felmértük, hogy ha a jelenség egy korábbi életszakaszban jelentkezett, akkor hány évesen, illetve hány év munkatapasztalatot követően múlt el, valamint, hogy a tapasztalt jelenség miként hatott az egyén munkateljesítményére. Az adatokat kereszttábla elemzéssel és statisztikai vizsgálatokkal értékeltük.
LEGFONTOSABB EREDMÉNYEK
Összesített eredményeink alapján megállapíthatjuk, hogy az imposztor szindróma a kutatásunkban résztvevő alanyok 86,4%-a esetében jelenleg is fennáll és mindössze 13,6%-uk érzi úgy, hogy megszűnt bizonyos kor elérése és szakmai tapasztalat megszerzését követően. A jelenség a mintában elsősorban felsősokú végzettséggel rendelkező nőket érinti, amely állandósult, jelenleg is fennálló belső szorongás érzését jelenti számukra. A szindróma intenzitása az életkor előre haladtával (és ezzel párhuzamosan a munkapasztalat növekedésével) csökkenhet és enyhe, mérsékelt hatást mutathat. A teljes mintában a tünetegyüttes alapvetően ösztönzőleg hat a teljesítményre és az életkor növekedésével csökken a jelenség teljesítményre gyakorolt blokkoló hatása.
GYAKORLATI JAVASLATOK
A kutatás eredményei hozzájárulhatnak az imposztor szindróma hazai előfordulásának részletesebb megismeréséhez, annak munkateljesítményre gyakorolt hatásának megértéséhez. További kutatási irányként a jövőben érdemes volna a mintaelemszámot növelve ágazat-, földrajzi/településnagyság, vezetői/nem vezetői munkakör specifikumokat meghatározni, valamint a pályájuk elején álló fiatal (25 év alatti) munkavállalók körében nagyobb számban megvizsgálni a jelenség előfordulásának jellemzőit.
A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage
Authors: Lau Rebecca K , Enustun Eray , Gu Yajie , Nguyen Justin V , Corbett Kevin D 
Published: September 2022

AbstractTo protect themselves from the constant threat of bacteriophage (phage) infection, bacteria have evolved diverse immune systems including restriction‐modification, CRISPR‐Cas, and many others. Here, we describe the discovery of a two‐protein transcriptional regulator module associated with hundreds of CBASS immune systems and demonstrate that this module drives the expression of its associated CBASS system in response to DNA damage. We show that the helix‐turn‐helix transcriptional repressor CapH binds the promoter region of its associated CBASS system to repress transcription until it is cleaved by the metallopeptidase CapP. CapP is activated in vitro by single‐stranded DNA, and in cells by DNA‐damaging drugs. Together, CapH and CapP drive increased expression of their associated CBASS system in response to DNA damage. We identify CapH‐ and CapP‐related proteins associated with diverse known and putative bacterial immune systems including DISARM and Pycsar antiphage operons. Overall, our data highlight a mechanism by which bacterial immune systems can sense and respond to a universal signal of cell stress, potentially enabling multiple immune systems to mount a coordinated defensive response against an invading pathogen.