bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing The Glory of Sri-Vijayan Empire Art Style in Southeast Asia
Authors: Syafrony Andre 
Published: August 2022

The link between civilizations influenced by Indian culture in Indonesia and Thailand has been thought-provoking. Many discoveries are mainly found in southern Thailand, which is similar to Javanese 9th-century artwork. This proves that the constituencies in South-East Asia had been in contact with each other in the past. Therefore, this paper aims to explore the concept of cultural influence and link it with the influence of Indian culture in South-East Asia, leading to the cultural conceptualization of the art style during the particular period of the Srivijaya Empire.

Hubungan antara peradaban yang dipengaruhi oleh budaya India di Indonesia dan Thailand telah lama menimbulkan kekaguman. Banyak penemuan di Thailand selatan, seperti karya seni Jawa abad ke-9. Ini membuktikan bahwa daerah-daerah kekuasaan di Asia Tenggara telah saling bertukar kebudayaan di masa lalu. Oleh karena itu, tulisan ini bertujuan untuk mengeksplorasi pengaruh budaya dan menghubungkannya dengan pengaruh budaya India di Asia Tenggara, yang mengarah pada konseptualisasi budaya gaya seni pada masa Kerajaan Sriwijaya dengan menggunakan analisis sastra dan dokumen
Peran Hukum Pajak dalam Meningkatkan Kepatuhan Wajib Pajak Membayar Pajak
Authors: Larasati Salsa Voni 
Published: August 2022

Tax is a very important source of state revenue. Tax law itself is a regulation that regulates taxation and the relationship between the state and taxpayers, the purpose of which is to clarify and reinforce tax procedures. In line with the theory of legal compliance, legal order is strongly influenced by the level of public awareness. Therefore, this article will discuss the role of tax law and public awareness in increasing tax compliance to realize prosperity. Using a descriptive method, the study was conducted with a conceptual approach by looking at the provisions of the Act and other legal sciences. The search and analysis were conducted based on the study of legal literature. The firmness and fairness of the tax law with public awareness play an important role in increasing taxpayer compliance and tax revenue that will be used for development to realize public welfare.
Pajak merupakan sumber pendapatan negara yang sangat penting. Hukum pajak sendiri adalah peraturan yang mengatur tentang perpajakan dan hubungan negara dengan orang atau badan wajib pajak, tujuannya memperjelas dan mempertegas prosedural pajak. Sejalan dengan teori kepatuhan hukum, ketertiban hukum sangat dipengaruhi oleh tingkat kesadaran masyarakatnya. Oleh sebab itu, artikel ini akan membahas tentang peranan hukum pajak dan kesadaran masyarakat dalam meningkatkan kepatuhan pajak sebagai upaya mewujudkan kesejahteraan. Menggunakan metode deskriptif, pengkajian dilakukan dengan pendekatan konseptual melihat ketentuan UU dan ilmu hukum lainnya. Penelusuran dan analisis dilakukan berdasarkan studi dokumen kepustakaan dan literatur hukum. Ketegasan dan keadilan hukum pajak yang dibersamai dengan kesadaran masyarakat berperan penting dalam meningkatkan kepatuhan wajib pajak dan jumlah penerimaan pajak yang akan digunakan untuk pembangunan dalam upaya mewujudkan kesejahteraan masyarakat.
Mussel-inspired polydopamine decorated alginate dialdehyde-gelatin 3D printed scaffolds for bone tissue engineering application
Authors: Ghorbani Farnaz , Kim Minjoo , Monavari Mahshid , Ghalandari Behafarid , Boccaccini Aldo R. 
Published: August 2022

This study utilized extrusion-based 3D printing technology to fabricate calcium-cross-linked alginate dialdehyde-gelatin scaffolds for bone regeneration. The surface of polymeric constructs was modified with mussel-derived polydopamine (PDA) in order to induce biomineralization, increase hydrophilicity, and enhance cell interactions. Microscopic observations revealed that the PDA layer homogeneously coated the surface and did not appear to induce any distinct change in the microstructure of the scaffolds. The PDA-functionalized scaffolds were more mechanically stable (compression strength of 0.69 ± 0.02 MPa) and hydrophilic (contact angle of 26) than non-modified scaffolds. PDA-decorated ADA-GEL scaffolds demonstrated greater durability. As result of the 18-days immersion in simulated body fluid solution, the PDA-coated scaffolds showed satisfactory biomineralization. Based on theoretical energy analysis, it was shown that the scaffolds coated with PDA interact spontaneously with osteocalcin and osteomodulin (binding energy values of −35.95 kJ mol−1 and −46.39 kJ mol−1, respectively), resulting in the formation of a protein layer on the surface, suggesting applications in bone repair. PDA-coated ADA-GEL scaffolds are capable of supporting osteosarcoma MG-63 cell adhesion, viability (140.18% after 7 days), and proliferation. In addition to increased alkaline phosphatase secretion, osteoimage intensity also increased, indicating that the scaffolds could potentially induce bone regeneration. As a consequence, the present results confirm that 3D printed PDA-coated scaffolds constitute an intriguing novel approach for bone tissue engineering.
Clinical and biochemical characteristics of diabetic ketoacidosis in adults with type 1 or type 2 diabetes at a tertiary hospital in the United Arab Emirates
Authors: Almazrouei Raya , Siddiqua Amatur Rahman , Alnuaimi Mouza , Al-Shamsi Saif , Govender Romona 
Published: August 2022

BackgroundDiabetes ketoacidosis (DKA) is a well-known acute complication of diabetes. This study aims to describe the sociodemographic, clinical, and biochemical characteristics of adult patients with different diabetes types and DKA severities attending a tertiary hospital in the UAE.MethodsWe retrospectively extracted sociodemographic, clinical, and laboratory data from the electronic medical records of 220 adult patients with DKA admitted to Tawam Hospital between January 2017 and October 2020.ResultsThe average age was 30.6 ± 16.6 years of whom 54.5% were women, 77.7% were UAE nationals and 77.9% were Type 1 diabetes (T1DM). 12.7% were newly diagnosed with diabetes. Treatment noncompliance (31.4%), and infection (26.4%) were the main precipitating factors. Most patients presented with moderate DKA (50.9%). Compared to T1DM, patients with Type 2 diabetes (T2DM) were older (53.6 vs 23.9 years, p &lt; 0.001), had longer hospital stay (12.1 days vs 4.1 days, p &lt; 0.001), had more complications (52.1%, vs 18.9% p &lt;0.001), and a higher mortality rate (6.3% vs 0.6%, p = 0.035). Patients with severe DKA had a shorter diabetes duration compared to mild and moderate DKA (5.7 vs 11.0 vs 11.7 years, respectively, p = 0.007), while complications were significantly lower in the mild group compared to both the moderate and severe groups (11.6% vs 32.1% vs 33.3%, respectively).ConclusionThe risk of DKA is higher for patients with T1DM than for those with T2DM. The clinical characteristics and outcomes of patients with T2DM differ from those with T1DM highlighting the importance of educating all patients about DKA.
Design, Synthesis, and Activity Assays of Cyclin-Dependent Kinase 1 Inhibitors With Flavone Scaffolds
Authors: Fu Lanlan , Mou Jiajia , Deng Yanru , Ren Xiaoliang , Qiu Shuang 
Published: August 2022

Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of flavone derivatives were discovered. Among them, compound 2a showed the best CDK1 inhibitory and anti-proliferative potencies in the in vitro activity investigation. The IC50 of 2a against CDK1 was 36.42 ± 1.12 μM vs. 11.49 μM ± 0.56 of flavopiridol. In the anti-proliferation activity assays, 2a exhibited better activity toward RAW264.7 than MCF-7 cells. The results indicated that flavone derivatives, besides inhibiting the growth of tumor cells, can also antagonize inflammatory response. Molecular docking results showed that conformation of 2a can form hydrogen bonds and various hydrophobic interactions with the key amino acid residues of CDK1. It can be used as a promising lead compound for CDK1 inhibitor development.
Molecular characterization of NDM-1-producing carbapenem-resistant E. cloacae complex from a tertiary hospital in Chongqing, China
Authors: Hu Kewang , Zhang Jisheng , Zou Jingbo , Zeng Lingyi , Li Jie , Wang Jianmin , Long Wenzhang , Zhang Xiaoli 
Published: August 2022

BackgroundThe aim of this study was to clarify the molecular characterization of NDM-1-producing carbapenem-resistant Enterobacter cloacae complex (CREL) at a teaching hospital in Chongqing, China.MethodsAntimicrobial susceptibility and resistance genes were analyzed. Epidemiological relationship was analyzed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Conjugation experiments were performed to determine the transferability of plasmids. Whole-genome sequencing (WGS) of strains was implemented, and the genetic environment of the blaNDM-1- and mcr-9-carrying plasmids was analyzed.ResultsA total of 10 blaNDM-1-positive CREL isolates were identified. All isolates harbored multiple resistance genes. ECL68 and ECL78 co-produce blaNDM-1 and mcr-9. Among the four different sequence types (STs) detected, ST1466 was assigned as a novel ST. Six isolates exhibited highly similar PFGE patterns. Conjugation assay proved that all plasmids containing blaNDM-1 or mcr-9 could be transferred to the recipient Escherichia coli. WGS indicated that blaNDM-1 genes were carried by diverse plasmids, including IncHI2/IncN, IncX3, and one unclassified plasmid type. The backbone structure of these plasmids is involved in replication initiation (repAB), partitioning (parABM), and conjugation/type IV secretion (tra/virB). Analysis of the genetic environment showed that blaNDM-1 in three plasmids exhibited a highly similar structure to protype Tn125. Co-existence of blaNDM-1 and the colistin resistance gene mcr-9 was detected in the two isolates, ECL68 and ECL78. In ECL68, blaNDM-1 and mcr-9 were present on the same plasmid while located in two separate plasmids in ECL78. The genetic environment of mcr-9 was organized as IS26-wbuC-mcr-9-IS903-pcoS-pcoE-rcnA-rcnR, and the two-component system encoding genes qseC and qseB was not found in two plasmids, which could explain mcr-9-harboring strains’ colistin susceptibility.ConclusionsWe first report a nosocomial outbreak of NDM-1-producing E. cloacae complex ST177 in China. Conjugative plasmids contributed to the horizontal transfer of antibiotic resistance genes. The prevalence and even coexistence of blaNDM-1 and mcr-9 may further threaten public health. Our results highlight further surveillance for blaNDM-1, and mcr-9 is essential to prevent its dissemination.
High prevalence of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates: A 5-year retrospective study at a Tertiary Hospital in Northern Thailand
Authors: Siriphap Achiraya , Kitti Thawatchai , Khuekankaew Akachai , Boonlao Chalermchai , Thephinlap Chonthida , Thepmalee Chutamas , Suwannasom Nittiya , Khoothiam Krissana 
Published: August 2022

BackgroundThe global emergence and spread of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales, especially Escherichia coli and Klebsiella pneumoniae, have been recognized as a public health concern as severe infections caused by these microorganisms increase morbidity and mortality. This study aimed to assess the prevalence of ESBL-positive E. coli and K. pneumoniae strains isolated from hospitalized patients in Chiangrai Prachanukroh hospital, Chiangrai province, Thailand.MethodsThis retrospective analysis was conducted from January 2016 to December 2020. A total of 384,001 clinical specimens were collected aseptically and further cultivated on an appropriate medium. All clinical isolates (one isolate per patient) were identified based on standard laboratory methods. Antibiotic susceptibility testing was performed by the Kirby Bauer disc diffusion technique following CLSI guidelines. ESBL production was screened with ceftazidime and cefotaxime discs based on the CLSI recommendations. Phenotypic confirmation of ESBL production was carried out using a double-disc synergy technique following the CLSI standard.ResultsOf a total of 384,001 clinical samples analyzed for bacterial species identification, 11,065 (2.9%) tested positive for E. coli and 5,617 (1.5%) for K. pneumoniae. Approximately 42.5% (4,706/11,065) of E. coli and 30.2% (1,697/5,617) of K. pneumoniae isolates were classified as ESBL producers. A higher proportion of ESBL producers was found in patients older than 60 years and male groups. The highest infection rates of ESBL-positive pathogens were observed among patients in a medical unit. ESBL-producing E. coli and K. pneumoniae isolates were predominantly found in urine and sputum, respectively. ESBL producers exhibited a high resistance rate to ampicillin (99.8–100%), cefazolin (100%), cefotaxime (100%), fluoroquinolones, and trimethoprim/sulfamethoxazole.ConclusionsThis study demonstrated the high prevalence and emerging antibiotic resistance of ESBL-positive E. coli and K. pneumoniae isolates from patients admitted to a provincial hospital in northern Thailand. Most ESBL-producing strains were highly resistant to several antimicrobial agents apart from carbapenems and aminoglycosides. These findings indicated that carbapenems and aminoglycosides should be advised as the first-line drugs of choice for serious infections with ESBL-producing Enterobacterales.
Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality
Authors: Ng Cheng Han , Wong Zhen Yu , Chew Nicholas W. S. , Chan Kai En , Xiao Jieling , Sayed Nilofer , Lim Wen Hui , Tan Darren Jun Hao , Loke Ryan Wai Keong , Tay Phoebe Wen Lin , Yong Jie Ning , Kong Gywneth , Huang Daniel Q. , Wang Jiong-Wei , Chan Mark , Dalakoti Mayank , Tamaki Nobuharu , Noureddin Mazen , Siddiqui Mohammad Shadab , Sanyal Arun J. , Muthiah Mark 
Published: August 2022

Background and aimsHypertension (HTN) is a common comorbidity in non-alcoholic fatty liver disease (NAFLD) affecting up to 40% of individuals. However, the impact of HTN and its control on outcomes in NAFLD remains unclear. Therefore, we aimed to examine the impact of HTN on survival outcomes in a longitudinal cohort of NAFLD patients.MethodsThe analysis consisted of adults in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 with data on socio-demographic characteristics and comorbidities. NAFLD was diagnosed with fatty liver index (FLI) and United States-FLI at a cut-off of 60 and 30, respectively in the substantial absence of alcohol use. A multivariate regression analysis was conducted to adjust for confounders.ResultsA total of 45,302 adults were included, and 27.83% were identified to have NAFLD. Overall, 45.65 and 35.12% of patients with NAFLD had HTN and uncontrolled HTN, respectively. A multivariate analysis with confounders demonstrated that hypertensive NAFLD had a significantly increased risk of all-cause mortality (HR: 1.39, CI: 1.14–1.68, p &lt; 0.01) and cardiovascular disease (CVD) mortality (HR: 1.85, CI: 1.06–3.21, p = 0.03). Untreated HTN remained to have a significantly increased risk in all-cause (HR: 1.59, CI: 1.28–1.96, p &lt; 0.01) and CVD mortality (HR: 2.36, CI: 1.36–4.10, p &lt; 0.01) while treated HTN had a non-significant increased risk of CVD mortality (HR: 1.51, CI: 0.87–2.63, p = 0.14) and a lower magnitude of increase in the risk of all-cause mortality (HR: 1.26, CI: 1.03–1.55, p = 0.03).ConclusionDespite the significant burden of HTN in NAFLD, up to a fifth of patients have adequate control, and the lack thereof significantly increases the mortality risk. With the significant association of HTN in NAFLD, patients with NAFLD should be managed with a multidisciplinary team to improve longitudinal outcomes.
Concurrent use of statins decreases major bleeding and intracerebral hemorrhage in non-valvular atrial fibrillation patients taking direct oral anticoagulants—A nationwide cohort study
Authors: Wu Hsin-Hsu , Chang Shang-Hung , Lee Tsong-Hai , Tu Hui-Tzu , Liu Chi-Hung , Chang Ting-Yu 
Published: August 2022

BackgroundStatins are frequently prescribed with direct oral anticoagulants (DOACs), and previous studies have raised concerns about the increased risk of intracerebral hemorrhage or other major bleeding in concurrent statins and DOACs use. The objective of this study is to evaluate the risk of major bleeding in non-valvular atrial fibrillation patients taking DOACs with or without statins.MethodsThis nationwide, retrospective cohort study used data from the Taiwan National Health Insurance Research Database, enrolled a total of 90,731 non-valvular atrial fibrillation patients receiving rivaroxaban, dabigatran, apixaban or edoxaban from January 1st, 2012 to December 31st, 2017. Major bleeding was defined as a hospitalization or emergency department visit with a primary diagnosis of intracerebral hemorrhage, gastrointestinal tract bleeding, urogenital tract bleeding, or other sites of bleeding. Adjusted incidence rate ratios (IRR) and differences of major bleeding between person-quarters of DOACs with or without statins were estimated using a Poisson regression and inverse probability of treatment weighting using the propensity score.Results50,854 (56.0%) of them were male with a mean age of 74.9 (SD, 10.4) years. Using DOACs without statins as a reference, the adjusted IRR for all major bleedings in concurrent use of DOACs and statins was 0.8 (95% CI 0.72–0.81). Lower major bleeding risk was seen in both low-to-moderate-intensity statins (IRR: 0.8, 95% CI 0.74–0.84) and high-intensity statins (IRR: 0.8, 95% CI 0.74–0.88). Concurrent use of DOACs and statins decreased the risk for intracerebral hemorrhage with an IRR of 0.8 (95% CI 0.66–0.93), and gastrointestinal tract bleeding with an IRR of 0.7 (95% CI 0.69–0.79). The protective effect of statins on intracerebral hemorrhage was observed only in female patients (IRR 0.67, 95% CI 0.51–0.89), but not in male patients (IRR 0.87, 95% CI 0.70–1.08).ConclusionsAmong non-valvular atrial fibrillation patients who were taking DOACs, concurrent use of statins decreased major bleeding risk, including intracerebral hemorrhage and gastrointestinal tract bleeding. Considering this and other cardioprotective effects, statins should be considered in all eligible patients prescribed with DOACs.
A First Evaluation of ERA5-Land Reanalysis Temperature Product Over the Chinese Qilian Mountains
Authors: Zhao Peng , He Zhibin 
Published: August 2022

Reanalysis temperature products are important datasets for temperature estimates over high-elevation areas with few meteorological stations. In this study, surface 2 m air temperature data from 17 meteorological stations from 1979 to 2017 in the Qilian Mountains (QLM) are used for comparison with the newest reanalysis product: ERA5-Land derived from the European Centre for Medium-Range Weather Forecasts (ECMWF). In general, the ERA5-Land temperature product can reproduce the observation variation at different time scales very well. A high monthly correlation coefficient that ranges from 0.978 to 0.998 suggests that ERA5-Land reanalysis temperature could capture the observations very well. However, attention should be paid before using ERA5-Land at individual sites because of the average root-mean-square-error (RMSE) of 2.2°C of all stations. The biases between ERA5-Land temperature and observations are mainly caused by the elevation differences between ERA5-Land grid points and meteorological sites. The annual mean temperature shows a significant warming trend (0.488°C/decade) from 1979 to 2017 based on the observations. ERA5-Land reanalysis temperature captures the increasing trend very well (0.379°C/decade). The biggest positive warming trends of observations and ERA5-Land are both found in summer with values of 0.574°C/decade and 0.496°C/decade, respectively. We suggest that ERA5-Land generally reproduces the temperature trend very well for observations and is reliable for scientific research over the QLM.
Prediction models constructed for Hashimoto’s thyroiditis risk based on clinical and laboratory factors
Authors: Li Peng , Liu Fang , Zhao Minsu , Xu Shaokai , Li Ping , Cao Jingang , Tian Dongming , Tan Yaopeng , Zheng Lina , Cao Xia , Pan Yingxia , Tang Hui , Wu Yuanyuan , Sun Yi 
Published: August 2022

BackgroundHashimoto’s thyroiditis (HT) frequently occurs among autoimmune diseases and may simultaneously appear with thyroid cancer. However, it is difficult to diagnose HT at an early stage just by clinical symptoms. Thus, it is urgent to integrate multiple clinical and laboratory factors for the early diagnosis and risk prediction of HT.MethodsWe recruited 1,303 participants, including 866 non-HT controls and 437 diagnosed HT patients. 44 HT patients also had thyroid cancer. Firstly, we compared the difference in thyroid goiter degrees between controls and patients. Secondly, we collected 15 factors and analyzed their significant differences between controls and HT patients, including age, body mass index, gender, history of diabetes, degrees of thyroid goiter, UIC, 25-(OH)D, FT3, FT4, TSH, TAG, TC, FPG, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Thirdly, logistic regression analysis demonstrated the risk factors for HT. For machine learning modeling of HT and thyroid cancer, we conducted the establishment and evaluation of six models in training and test sets.ResultsThe degrees of thyroid goiter were significantly different among controls, HT patients without cancer (HT-C), and HT patients with thyroid cancer (HT+C). Most factors had significant differences between controls and patients. Logistic regression analysis confirmed diabetes, UIC, FT3, and TSH as important risk factors for HT. The AUC scores of XGBoost, LR, SVM, and MLP models indicated appropriate predictive power for HT. The features were arranged by their importance, among which, 25-(OH)D, FT4, and TSH were the top three high-ranking factors.ConclusionsWe firstly analyzed comprehensive factors of HT patients. The proposed machine learning modeling, combined with multiple factors, are efficient for thyroid diagnosis. These discoveries will extensively promote precise diagnosis, personalized therapies, and reduce unnecessary cost for thyroid diseases.