bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Nomogram for Predicting the Occurrence of Symptomatic Intracranial Haemorrhage after Thrombectomy: A Single-Center Retrospective Observational Study
Authors: Wang YunHui , Tu Qi , Zhao TingTing , Ye Qiang , Zheng Kuang , Zhang WeiZhong , Li ZeQun 
Published: February 2022

Abstract
Background
Symptomatic intracranial haemorrhage (SICH) is a severe and deadly complication in patients with large vessel occlusion (LVO) who receive endovascular treatment (EVT). Recent studies have indicated that many risk factors, including pretreatment scores and the operation process, may be associated with the occurrence of SICH after thrombectomy. This study aims to identify independent risk factors and establish a novel nomogram-based model for patients with anterior LVO to predict the occurrence of SICH after direct thrombectomy or bridge therapy (thrombectomy based on intravenous thrombolysis).
Methods
Patients with acute ischaemic stroke after EVT to recanalize the blocked artery in anterior circulation were consecutively recruited from November 2017 to March 2019. Baseline information was collected from each patient. These data were subsequently analysed by R Project for Statistical Computing.
Results
A total of 127 patients with complete data were classified into the training set, among whom 37 patients (29.1%) fulfilled the criteria for SICH. The results of the multivariate analyses showed that NIHSS (P=0.024), ASPECT (P<0.001) and ASITN (P=0.017) scores were independently associated with the occurrence of SICH after thrombectomy. Ultimately, three independent pretreatment predictors were included in the NIHSS/ASPECT/ASITN (NAA) prediction model, and the receiver operating characteristic analysis results showed an area under the curve (AUC) of 0.845 (95% CI=0.763–0.928). The calibration plots showed that the actual observations were consistent with the measured and predicted results of the nomogram.
Conclusions
In this study, a novel model based on NAA for predicting the occurrence of SICH after thrombectomy in patients with anterior LVO was established and validated internally. The results suggest that this model can help improve perioperative evaluations and individualized treatment strategies.
Body Image Distress among Cancer Patients: Needs for Psychosocial Intervention Development
Authors: N/A Nikita , Rani Ruchika , Kumar Rajesh 
Published: February 2022

Abstract
Objectives: This study examines the body image associated distress among patients with head and neck cancer visiting a tertiary care hospital for follow-ups.Design: An exploratory, cross-sectional design enrolled 170 patients with head and neck cancer purposively undergone cancer surgery at a newly established tertiary care hospital, North India. Methods: A structured pre-tested socio-demographic and clinical profile checklist and the Derriford Appearance Scale 24 (DAS-24) were used to collect information. An appropriate descriptive and inferential statistic was applied to compute the findings. Results: The mean age of the participants was 47.98 (SD=12.1) years, and 80% of the participants were unemployed. The mean body image distress score was 57.95 (SD=10.3, 47-66.75, range 42-77). The body image distress found a significant association with age (p<.001), gender (p=0.003), and working status of the patients (p=0.032). Multilinear regression reported gender as an independent predictor (95% CI: 0.615 - 8.646, p=0.025) for body image distress in patients.Conclusions: Patients with head and neck cancer have significant psychosocial distress due to changes in body appearance. Female patients who had undergone surgery at young age reported higher distress. We should include body image and rehabilitation in the daily care of patients. Recommending the use of cosmetic surgery on routine follow-ups is another strategy to improve facial appearance to overcome the negative impact of body image.
Study on Collapse Mechanism and Treatment Measures of Portal Slope of a High-speed Railway Tunnel
Authors: Hu Guoping , Xia Yingzhi , Zhong Lianggen , Ruan Xiaoxue , Wang Qingguo 
Published: February 2022

Abstract
The slope of an open cut tunnel is located above the exit of the Leijia tunnel on the Changgan high-speed railway. During the excavation of the open cut tunnel foundation pit, the slope slipped twice, a large landslide of 92500 m³ formed. The landslide body and unstable slope body not only caused the foundation pit of the open cut tunnel to be buried and the anchor piles to be damaged but also directly threatened the operational safety of the later high-speed railway. Therefore, to study the stability change in the slope of the open cut tunnel under heavy rain and excavation conditions, a 3D numerical calculation model of the slope is carried out by Midas GTS software, the deformation mechanism is analyzed, anti-sliding measures are proposed, and the effectiveness of the anti-sliding measures is analyzed according to the field monitoring results. The results show that when rainfall occurs, rainwater collects in the open cut tunnel area, resulting in a transient saturation zone on the slope on the right side of the open cut tunnel, which reduces the shear strength of the slope soil; the excavation at the slope toe reduces the anti-sliding capacity of the slope toe. Under the combined action of excavation and rainfall, when the soil above the top of the anchor pile is excavated, two potential sliding surfaces are bounded by the top of the excavation area, and the shear outlet is located at the top of the anchor pile. After the excavation of the open cut tunnel, the potential sliding surface is mainly concentrated at the lower part of the downhill area, and the shear outlet moves down to the bottom of the open cut tunnel. Based on the deformation characteristics and the failure mechanism of the landslides, comprehensive control measures, including interim emergency mitigation measures and long-term mitigation measures, are proposed. The field monitoring results further verify the accuracy of the anti-sliding mechanism analysis and the effectiveness of anti-sliding measures.
Optimization of Phosphate Oxygen Isotope Pretreatment Measurement Method Based on Hosphate In-situ Enrichment Blanket
Authors: Li Sumei , Du Chengyu , Jin Xin , Yang Jing , Zhang Wei , Li Simin 
Published: February 2022

Abstract
Phosphate oxygen isotope analysis is an effective tool for investigating phosphorus migration and transformation in water bodies. However, existing pretreatment methods for this technology are severely restricted by large sample requirements, cumbersome operation, and poor applicability. To optimize the pretreatment method, hydrated zirconia was prepared by liquid-phase precipitation. Zeolite, D001 macroporous resin, activated carbon, and ceramsite were selected as potential support materials. The optimum zirconium support material was selected after field enrichment and laboratory elution experiments. The optimum in situ enrichment time, material dose, and elution time were determined using response surface methodology. The D001 resin provided the best selective adsorption and elution capacity for phosphate. The optimum parameters for an in situ phosphate-enrichment blanket were obtained by response surface optimization as a zirconium-loaded D001 resin mass of 13 g, enrichment time of 360 min, and elution time of 853 min. After purification, a bright yellow Ag3PO4 solid was obtained. The results showed that the optimization method was reliable. These results provide a foundation for the application of phosphate oxygen isotope analysis in freshwater bodies.
Genetic Characterization of Rare Bruconha Virus (Bunyavirales: Orthobunyavirus) Isolated in Vale Do Ribeira (Atlantic Forest Biome), Southeastern Brazil
Authors: Costa Antonio Charlys da , Morais Vanessa dos Santos , de Azevedo Roberta Marcattti , Nuevo Karolina Morales Barrio , Cunha Mariana Sequetin 
Published: February 2022

Abstract
Brazil is a great source of arbovirus diversity, mainly in the Amazon Region. However, other biomes, especially Atlantic Forest, may be also a hotspot for emergent viruses, including Bunyaviruses (Negarnaviricota: Bunyavirales). For instance, Vale do Ribeira, located in the Southeastern region, has been widely studied for virus surveillance, where Flavivirus, Alphavirus and Bunyaviruses were isolated during the last decades, including Bruconha virus (BRCV), a member of Orthobunyavirus genus Group C, in 1976. Recently, a new isolated of BRCV, named Span321532, was obtained from an adult sentinel mice placed in Iguape county, in 2011, and a full-length genome was generated, with nucleotide differences that varied from 1.5%, 5.3% and 5% (L, M and S segments respectively) from the prototype isolated 35 years earlier. Although no evidence of reassortants were detected, this findings reiterates the need for new surveillance and genomic studies in the area considering the high mutation rates of arbovirus and also to identify the hosts capable of supporting the continuous circulation of Orthobunyavirus.
A Comparative Analysis of Health Status of International Migrants and Local Population in Chile: a Population-based, Cross-sectional Analysis From a Social Determinants of Health Perspective
Authors: Rada Isabel , Oyarte Marcela , Cabieses Baltica 
Published: February 2022

Abstract
Background: During recent decades intraregional migration has increased in Latin America. Chile became one of the main receiving countries and hosted diverse international migrant groups. Evidence have suggested a healthy migrant effect (HME) on health status but remains scarce, controversial and needs to be updated. This study performed a comprehensive analysis verifying the existence of HME and its association with social determinants of health (SDH). Methods: We analyzed data from the Chilean National Socioeconomic Characterization Survey (CASEN, version 2017). Crude prevalence of health status indicators such as negative self-perceived health, chronic morbidity, disability and activity limitations were described in both international migrants and local population. The association between these outcomes and demographic, socioeconomic, access to health care, psychosocial and migratory related factors were tested using multivariate logistic regression in each population. The HME was also tested using multivariate logistic regression, sequentially adjusted for each set of SDH to obtain the odds ratio of presenting each health outcome if being an international migrant (ref=Chilean). Results: International migrants had lower crude prevalence of all health indicators than Chileans. Age, unemployment and health care system affiliation were associated with health outcomes in both populations. Psychosocial determinants were both risk and protective factors. Crude analysis revealed an apparent HME in all health outcomes. After adjustment for each set of SDH, the immigrant health advantage was only significant for chronic morbidity. Being migrant was associated with 39% lower odds of having chronic diseases compared to locals (OR: 0,61; 95% CI: 0,44-0,84; P = 0,0003). For all other conditions, HME disappeared after adjusting by SDH, particularly unemployment, type of health system and psychosocial factors. Conclusions: Testing the HME in Chile reveals an advantage for chronic morbidities that remained significant after adjustment for SDH. This analysis shed light on health disparities between international migrants and local population in the Latin American region, with special relevance of unemployment, type of health system and psychosocial factors. As well as differential exposures faced during migration process that could dissolve the HME over time. Evidence from this integrative approach is useful for informed health planning and intersectoral local and regional solutions.
Measurements of American lobster heart rate and movements in the wild using a low-cost open source datalogger
Authors: Gutzler Benjamin , Watson Winsor H. 
Published: February 2022

Abstract
To better understand the behavior of the American lobster (Homarus americanus) in the wild, we developed the C-HAT (Crustacean Heart and Activity Tracker): a datalogger capable of continuously recording the triaxial acceleration, compass heading, and heart rate of lobsters that are freely moving in their natural habitat. C-HATs and acoustic transmitters were affixed to six lobsters that were released within an acoustic positioning array off the coast of New Hampshire (USA) and recaptured by divers after 15-47 hours at large. Lobster heart rates tended to be ~60 beats per minute (bpm) at rest, but increased to ~80 bpm during periods of activity. The presence of brief cardiac startle responses during the beginning of some periods of activity suggested that at least a third of their movement bouts occurred in response to external stimuli, such as interactions with other species. The combination of acoustic positioning data and datalogging allowed us to determine if various indices of acceleration could be used to estimate distance traveled. We found a significant correlation between a Movement Index (MI), based on differentiation of the three axes of acceleration, and the distance lobsters traveled in 10 min based on telemetry data. This enabled us to use the MI in concert with compass headings to reconstruct lobster movement paths via dead reckoning. This study demonstrates the potential for low-cost, open-source, dataloggers to provide detailed information on the daily behavior and physiology of marine invertebrates in the wild.
Antigen footprint governs activation of the B cell receptor
Authors: Ferapontov Alexey , Omer Marjan , Baudrexel Isabelle , Nielsen Jesper , Dupont Daniel , Juul-Madsen Kristian , Steen Philipp , Thiel Steffen , Vorup-Jensen Thomas , Jungmann Ralf , Kjems Jørgen , Degn Søren 
Published: February 2022

Abstract
Antigen binding by B cell receptors (BCRs) on cognate B cells elicits a response that eventually leads to production of antibodies. However, it is unclear what the distribution of BCRs is on the naïve B cell and how antigen binding triggers the first step in BCR signaling. Using DNA-PAINT super-resolution microscopy, we find that most BCRs are present as monomers, dimers, or lower-order oligomers on resting B cells, with a nearest-neighbor inter-Fab distance of 20-30 nm. We leverage a Holliday junction nanoscaffold to engineer monodisperse model antigens with precision-controlled affinity and valency, and find that the antigen exerts agonistic effects on the BCR as a function of increasing affinity and avidity. Monovalent macromolecular antigens can activate the BCR at high concentrations, whereas micromolecular antigens cannot, demonstrating that antigen binding does not directly drive activation. Based on this, we propose a novel BCR activation model determined by the antigen footprint.
Modeling Fall Armyworm Resistance in Bt-maize Areas During Crop and Off-seasons
Authors: Tomé Maysa Pereira , Weber Igor Daniel , Garcia Adriano Gomes , Jomielniak Josemeri Aparecida , Wajnberg Eric , Hay-Roe Mirian M. , Godoy Wesley A.C. 
Published: February 2022

Abstract
Entomologists have often used computational modeling to study the dynamics of insects in agricultural landscapes. Recently, important issues such as the movement of adults and immatures associated with insect resistance to GMO (genetically modified organism) crops, have been addressed using computational models. Further studies are needed, especially of structured landscapes composed of GMO plants and alternative hosts that insect pests can exploit. We developed an individual-based model using the cellular automata approach (CA) to investigate how an intercropping system composed of transgenic maize (Bacillus thuringiensis), refuge areas (non-Bt maize), and grasses combined with off-season periods might influence the evolution of resistance in Spodoptera frugiperda (Lepidoptera: Noctuidae), one of the leading agricultural pests targeted by GMOs. We designed the Bt and non-Bt plants in two different arrangements: a) a seed mixture and b) alternate rows, adding grasses in areas adjacent to the field. We added the seasonal planting dynamics (crop season and off-season), to evaluate a total of six agricultural scenarios. We followed a crop calendar from the United States to create simulations close to agricultural practice. The results showed that the frequency of the resistance allele was strongly related to the landscape arrangements and their dynamics. Since the adult insects are mobile, the seed-mixture scenario increased the frequency of the resistance allele the most, followed by alternate rows. Finally, grass fields can help to manage S. frugiperda Bt resistance in the agricultural scenarios.
Analysis of the Characteristics of Wind Power and Topography Influence on It, With an Approach to Renewable Energy Generation (Synoptic Meteorological Stations of Mazandaran Province - Northern Iran)
Authors: Bairamvand Reyhaneh , Motevalli Sadroddin , Ghobadi GholamReza Janbaz , Derafshi Khabat 
Published: February 2022

Abstract
There has been a growing demand for energy in the province of Mazandaran in recent years. Considering the capabilities of the province to generate new energy, recognizing and consuming wind energy as a source of renewable energy should be a planning priority. In this study, a statistical analysis of daily wind speed and direction at a height of 10 m in15 synoptic meteorological stations of Mazandaran Province over a 12-year period (2006 to 2017) was conducted to provide a preliminary estimate of the extractable energy and spatial capacity of wind flow. In addition, the characteristics of wind speed and direction, Weibull probability distribution parameters and wind power potential and density of the stations were also determined. ArcGIS interpolation method (IDW) was used to prepare the calculated layers of the average speed, speed continuity, and power density of the wind at 10, 30, and 50 m heights. Furthermore, to examine the influence of topography on the wind variables, the Pearson correlation coefficient was used to evaluate the relationship between altitude, hillslope aspect, and slope indicators with each of the wind variables. A map of wind speed zones at 50 m height reveals that Baladeh station, with an average monthly wind speed of 5.98 m/s, has a maximum wind speed of 7.78 m/s in July. About 7 months of the year (April to October), the station records wind speeds of more than 6 m/s, especially during the warmer months. The study of spatial distribution of wind speed at different altitudes of the province shows that the average wind speed increases by 0.96 m/s to 2.91 m/s with increasing altitude from less than 200 m to over 5000 m.
Enhancing resilience of at-risk social groups to climate change in two contrasting ecosystems in the semi-arid Far North Region Cameroon
Authors: Njoya Hamza Moluh , Eshetu Shibire Bekele , Msangi Haji Athumani , Wouapi Herve Alain Napi , Loehr Katharina , Sieber Stefan 
Published: February 2022

Abstract
Climate change and variability contribute to exacerbating poverty and social tensions in poor countries. This research examines the underlying processes that contribute to a shared understanding of the socio-ecological resilience of upland and floodplain farming systems in the Far North Region of Cameroon. Built on community-based data and 28 key informant interviews to characterize farmers’ livelihoods, including implications of (non) climate factors on the latter, the research uses qualitative content analysis for data validation and analysis. The study reveals that the majority of farmers are most concerned about erratic rains and false starts, two major constraints for farm output. Further, the breakup of social capital as community members scatter in desperate search of alternative livelihood options is another factor. Overall, the resilience of farming communities in the studied areas is largely undermined by exposure to water- and vector-borne diseases, inadequate village infrastructure, lack of timely access to quality agro-input, seasonal weather forecasts, and institutional support. Food shortages are a potential consequence. Further, over-reliance on grazing land and water leaves herders with little or no viable options, just a narrow window to move their livestock to the neighbouring Chad Republic in a quest for fodder – a costly and counterproductive option. Finally, the findings suggest effectual coping strategies and a culture of adaptive management, including the establishment of relevant institutions to lessen vulnerability and foreseeable threats to food security in the semiarid climate change hotspots of the Far North region Cameroon.
Interprofessional Education Research: Disciplines, Authorship Practices, Research Design, and Dissemination Trends
Authors: Olsen Amanda A. , Lupton-Smith Carly P. , Dallaghan Gary L. Beck , McLaughlin Jacqueline E. 
Published: February 2022

Abstract
Background: In 2007, the World Health Organization launched the Programme on Interprofessional Education and Collaborative Practice to emphasize the importance of interprofessional education (IPE). Since then, numerous IPE reviews have focused on what has been implemented and evaluated. The purpose of this review was to explore how IPE has been implemented and evaluated. Methods: The following aspects of IPE research were explored: 1) disciplines included; 2) authorship patterns, 3) assessment focus, and 4) dissemination trends. Abstracts were screened before a full text screening, review, data extraction, analysis and audit. Frequency and percentages were reported for categorical data while means and standard deviations were reported for continuous data. Chi-squared analyses examined differences between groups for categorical variables. Results: Three-hundred and fifty-nine articles met the inclusion criteria. Authors from medical, nursing, and pharmacy schools published most frequently, with a majority using quantitative or mixed-methods techniques. Most studies involved a student discipline without an author from that discipline. Most studies also evaluated student perceptions. Studies were published in 98 journals, most of which were interdisciplinary journals, with the largest increase in publications in the most recent year of the review. Conclusion: IPE research has grown substantially over the past 10 years. Consideration should be given to expanding IPE research methodologies, strategically publishing IPE findings, and promoting authorship representation for student disciplines involved in IPE.