bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women
Authors: Koga Kayoko , Hara Megumi , Shimanoe Chisato , Nishida Yuichiro , Furukawa Takuma , Iwasaka Chiharu , Tanaka Keitaro , Otonari Jun , Ikezaki Hiroaki , Kubo Yoko , Kato Yasufumi , Tamura Takashi , Hishida Asahi , Matsuo Keitaro , Ito Hidemi , Nakamura Yohko , Kusakabe Miho , Nishimoto Daisaku , Shibuya Keiichi , Suzuki Sadao , Watanabe Miki , Ozaki Etsuko , Matsui Daisuke , Kuriki Kiyonori , Takashima Naoyuki , Kadota Aya , Arisawa Kokichi , Katsuura-Kamano Sakurako , Takeuchi Kenji , Wakai Kenji 
Published: January 2022

AbstractElucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction = 0.003). Unexpectedly, problem solving in men (Ptrend < 0.001) and positive reappraisal in women (Ptrend = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.
Qualitative and quantitative methods detection of SDS based on polyelectrolyte microcapsules
Authors: Kim Aleksandr L. , Musin Egor V. , Dubrovskii Alexey V. , Tikhonenko Sergey A. 
Published: January 2022

AbstractSodium dodecyl sulfate (SDS) is the most widely used anionic surfactant. Its frequent use causes environmental pollution and negative effects on living organisms (even at low concentrations ≈ 20 μg/ml). Thus, cheap and fast methods are needed to detect this surfactant in wastewater and surface waters in order to prevent the negative effects of SDS on the environment and human beings. We discovered that sodium dodecyl sulfate is capable of destroying polyelectrolyte microcapsules, which has been demonstrated by the number of sedimented polyelectrolyte microcapsules (PMC) before and after incubation in SDS solution. Therefore, it was proposed to use PMCs to create qualitative and quantitative diagnostic systems for the determination of SDS in solution. The qualitative system is a polyelectrolyte microcapsules containing polyallylamine labeled with a fluorescent dye—FITC. An excess SDS concentration of more than 5 μg/ml in the analyzed medium leads to the destruction of PMC and an increase in the fluorescence intensity of the solution, which is recorded by a fluorometer. The quantitative diagnostic system is based on turbidimetry of the PMC suspension before and after incubation in an anionic surfactant solution. This system has a range of detectable SDS concentrations from 10 to 50 μg/ml, with a standard deviation of no more than 11%.
Automated segmentation of articular disc of the temporomandibular joint on magnetic resonance images using deep learning
Authors: Ito Shota , Mine Yuichi , Yoshimi Yuki , Takeda Saori , Tanaka Akari , Onishi Azusa , Peng Tzu-Yu , Nakamoto Takashi , Nagasaki Toshikazu , Kakimoto Naoya , Murayama Takeshi , Tanimoto Kotaro 
Published: January 2022

AbstractTemporomandibular disorders are typically accompanied by a number of clinical manifestations that involve pain and dysfunction of the masticatory muscles and temporomandibular joint. The most important subgroup of articular abnormalities in patients with temporomandibular disorders includes patients with different forms of articular disc displacement and deformation. Here, we propose a fully automated articular disc detection and segmentation system to support the diagnosis of temporomandibular disorder on magnetic resonance imaging. This system uses deep learning-based semantic segmentation approaches. The study included a total of 217 magnetic resonance images from 10 patients with anterior displacement of the articular disc and 10 healthy control subjects with normal articular discs. These images were used to evaluate three deep learning-based semantic segmentation approaches: our proposed convolutional neural network encoder-decoder named 3DiscNet (Detection for Displaced articular DISC using convolutional neural NETwork), U-Net, and SegNet-Basic. Of the three algorithms, 3DiscNet and SegNet-Basic showed comparably good metrics (Dice coefficient, sensitivity, and positive predictive value). This study provides a proof-of-concept for a fully automated deep learning-based segmentation methodology for articular discs on magnetic resonance images, and obtained promising initial results, indicating that the method could potentially be used in clinical practice for the assessment of temporomandibular disorders.
Ethanol reduces the minimum alveolar concentration of sevoflurane in rats
Authors: Müller Johannes , Plöchl Walter , Mühlbacher Paul , Graf Alexandra , Kramer Anne-Margarethe , Podesser Bruno Karl , Stimpfl Thomas , Hamp Thomas 
Published: January 2022

AbstractA high number of trauma patients are under the influence of alcohol. Since many of them need immediate surgical procedures, it is imperative to be aware of the interaction of alcohol with general anesthesia. To counter challenges that arise from clinical studies, we designed an animal experiment in which 48 adult Wistar rats either received 1 g · kg−1 ethanol, 2 g · kg−1 ethanol or placebo via intraperitoneal application. Subsequently, they were anesthetized with an individual concentration of sevoflurane. The minimum alveolar concentration (MAC) of the different groups was assessed using Dixon’s up-and-down design and isotonic regression methods. The bootstrap estimate of the MAC of sevoflurane in the placebo group was 2.24 vol% (95% CI 1.97–2.94 vol%). In the low dose ethanol group, the bootstrap estimate was 1.65 vol% (95% CI 1.40–1.98 vol%), and in the high dose ethanol group, it was 1.08 vol% (95% CI 0.73–1.42 vol%). We therefore report that intraperitoneal application of 1 g · kg−1 or 2 g · kg−1 ethanol both resulted in a significant reduction of the MAC of sevoflurane in adult Wistar rats: by 26.3% and 51.8% respectively as compared to placebo.
Analysis of postures for handwriting on touch screens without using tools
Authors: Marullo Sara , Pozzi Maria , Malvezzi Monica , Prattichizzo Domenico 
Published: January 2022

AbstractThe act of handwriting affected the evolutionary development of humans and still impacts the motor cognition of individuals. However, the ubiquitous use of digital technologies has drastically decreased the number of times we really need to pick a pen up and write on paper. Nonetheless, the positive cognitive impact of handwriting is widely recognized, and a possible way to merge the benefits of handwriting and digital writing is to use suitable tools to write over touchscreens or graphics tablets. In this manuscript, we focus on the possibility of using the hand itself as a writing tool. A novel hand posture named FingerPen is introduced, and can be seen as a grasp performed by the hand on the index finger. A comparison with the most common posture that people tend to assume (i.e. index finger-only exploitation) is carried out by means of a biomechanical model. A conducted user study shows that the FingerPen is appreciated by users and leads to accurate writing traits.
Population-based survival for cancer patients in Saudi Arabia for the years 2005–2009
Authors: Aseafan Mohamed , Devol Edward , AlAhwal Mahmoud , Souissi Riad , Sindi Reham , AlEid Haya , Bazarbashi Shouki 
Published: January 2022

AbstractThe Saudi Cancer Registry reported in 2007 the 5-year observed survival for the most common cancer sites for the years 1994–2004. In this report we looked at the cancer survival in the period 2005–2009 and evaluated the trend over the 15 years period from 1994 to 2009. Cases of the top 14 cancer sites reported by the population based Saudi Cancer Registry from 1 January 2005 to December 31, 2009, were submitted for survival analysis. The vital status of those patients was collected. Analysis of survival for the above period was compared with the prior reported 2 periods (1994–1999, 2000–2004). In addition, analysis was done according to age, sex, disease stage and the province. Data of 25,969 patients of the commonest cancer sites were submitted. Of those 14,146 patients (54%) had complete demographic data available and vital status was reported. Thyroid cancer had the highest 5- year observed survival of 94% (95% confidence interval (CI) 93–95%)), followed by Breast (72%, 95% CI 71–74%). In hematological malignancies, Hodgkin’s Lymphoma had the highest 5-year survival of 86% (95% CI 84–88%). Survival rates has improved in most of the cancers sites for the studied periods except for lung, uterine and Hodgkin’s lymphoma which plateaued. Our study confirms a steady improvement in the 5-year observed survival over time for the majority of cancers. Our survival data were comparable to western countries. This data should be used by policy makers to improve on cancer care in the kingdom.
Stage specific comparative transcriptomic analysis to reveal gene networks regulating iron and zinc content in pearl millet [Pennisetum glaucum (L.) R. Br.]
Authors: Satyavathi C. Tara , Tomar Rukam S. , Ambawat Supriya , Kheni Jasminkumar , Padhiyar Shital M. , Desai Hiralben , Bhatt S. B. , Shitap M. S. , Meena Ramesh Chand , Singhal Tripti , Sankar S. Mukesh , Singh S. P. , Khandelwal Vikas 
Published: January 2022

AbstractPearl millet is an important staple food crop of poor people and excels all other cereals due to its unique features of resilience to adverse climatic conditions. It is rich in micronutrients like iron and zinc and amenable for focused breeding for these micronutrients along with high yield. Hence, this is a key to alleviate malnutrition and ensure nutritional security. This study was conducted to identify and validate candidate genes governing grain iron and zinc content enabling the desired modifications in the genotypes. Transcriptome sequencing using ION S5 Next Generation Sequencer generated 43.5 million sequence reads resulting in 83,721 transcripts with N50 of 597 bp and 84.35% of transcripts matched with the pearl millet genome assembly. The genotypes having high iron and zinc showed differential gene expression during different stages. Of which, 155 were up-regulated and 251 were down-regulated while during flowering stage and milking stage 349 and 378 transcripts were differentially expressed, respectively. Gene annotation and GO term showed the presence of transcripts involved in metabolic activities associated with uptake and transport of iron and zinc. Information generated will help in gaining insights into iron and zinc metabolism and develop genotypes with high yield, grain iron and zinc content.
Extremely high upper critical field in BiCh2-based (Ch: S and Se) layered superconductor LaO0.5F0.5BiS2−xSex (x = 0.22 and 0.69)
Authors: Hoshi Kazuhisa , Kurihara Ryosuke , Goto Yosuke , Tokunaga Masashi , Mizuguchi Yoshikazu 
Published: January 2022

AbstractCentrosymmetric compounds with local inversion symmetry breaking have tremendously interesting and intriguing physical properties. In this study, we focus on a BiCh2-based (Ch: S, Se) layered superconductor, as a system with local inversion asymmetry, because spin polarisation based on the Rashba–Dresselhaus-type spin–orbit coupling has been observed in centrosymmetric BiCh2-based LaOBiS2 systems, while the BiCh2 layer lacks local inversion symmetry. Herein, we report the existence of extremely high in-plane upper critical fields in the BiCh2-based system LaO0.5F0.5BiS2−xSex (x = 0.22 and 0.69). The superconducting states are not completely suppressed by the applied magnetic fields with strengths up to 55 T. Thus, we consider that the in-plane upper critical field is enhanced by the local inversion symmetry breaking and its layered structure. Our study will open a new pathway for the discovery of superconductors that exhibit a high upper critical field by focusing on the local inversion symmetry breaking.
Evaluation of reference genes and characterization of the MYBs in xylem radial change of Chinese fir stem
Authors: Li Kui-Peng , Li Wei , Tao Gui-Yun , Huang Kai-Yong 
Published: January 2022

AbstractThe radial change (RC) of tree stem is the process of heartwood formation involved in complex molecular mechanism. Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.), an evergreen species, is an important fast-growing timber tree in southern China. In this study, the top four stable genes (IDH, UBC2, RCA and H2B) were selected in RC tissues of 15 years old Chinese fir stem (RC15) and the genes (H2B, 18S, TIP41 and GAPDH) were selected in RC tissues of 30 years old Chinese fir stem (RC30). The stability of the reference genes is higher in RC30 than in RC15. Sixty-one MYB transcripts were obtained on the PacBio Sequel platform from woody tissues of one 30 years old Chinese fir stem. Based on the number of MYB DNA-binding domain and phylogenetic relationships, the ClMYB transcripts contained 21 transcripts of MYB-related proteins (1R-MYB), 39 transcripts of R2R3-MYB proteins (2R-MYB), one transcript of R1R2R3-MYB protein (3R-MYB) belonged to 18 function-annotated clades and two function-unknown clades. In RC woody tissues of 30 years old Chinese fir stem, ClMYB22 was the transcript with the greatest fold change detected by both RNA-seq and qRT-PCR. Reference genes selected in this study will be helpful for further verification of transcript abundance patterns during the heartwood formation of Chinese fir.
Discovery of solabiose phosphorylase and its application for enzymatic synthesis of solabiose from sucrose and lactose
Authors: Saburi Wataru , Nihira Takanori , Nakai Hiroyuki , Kitaoka Motomitsu , Mori Haruhide 
Published: January 2022

AbstractGlycoside phosphorylases (GPs), which catalyze the reversible phosphorolysis of glycosides, are promising enzymes for the efficient production of glycosides. Various GPs with new catalytic activities are discovered from uncharacterized proteins phylogenetically distant from known enzymes in the past decade. In this study, we characterized Paenibacillus borealis PBOR_28850 protein, belonging to glycoside hydrolase family 94. Screening of acceptor substrates for reverse phosphorolysis, in which α-d-glucose 1-phosphate was used as the donor substrate, revealed that the recombinant PBOR_28850 produced in Escherichia coli specifically utilized d-galactose as an acceptor and produced solabiose (β-d-Glcp-(1 → 3)-d-Gal). This indicates that PBOR_28850 is a new GP, solabiose phosphorylase. PBOR_28850 catalyzed the phosphorolysis and synthesis of solabiose through a sequential bi-bi mechanism involving the formation of a ternary complex. The production of solabiose from lactose and sucrose has been established. Lactose was hydrolyzed to d-galactose and d-glucose by β-galactosidase. Phosphorolysis of sucrose and synthesis of solabiose were then coupled by adding sucrose, sucrose phosphorylase, and PBOR_28850 to the reaction mixture. Using 210 mmol lactose and 280 mmol sucrose, 207 mmol of solabiose was produced. Yeast treatment degraded the remaining monosaccharides and sucrose without reducing solabiose. Solabiose with a purity of 93.7% was obtained without any chromatographic procedures.
Amikacin potentiator activity of zinc complexed to a pyrithione derivative with enhanced solubility
Authors: Magallon Jesus , Vu Peter , Reeves Craig , Kwan Stella , Phan Kimberly , Oakley-Havens Crista L. , Rocha Kenneth , Jimenez Veronica , Ramirez María Soledad , Tolmasky Marcelo E. 
Published: January 2022

AbstractResistance to amikacin in Gram-negatives is usually mediated by the 6'-N-acetyltransferase type Ib [AAC(6')-Ib], which catalyzes the transfer of an acetyl group from acetyl CoA to the 6' position of the antibiotic molecule. A path to continue the effective use of amikacin against resistant infections is to combine it with inhibitors of the inactivating reaction. We have recently observed that addition of Zn2+ to in-vitro enzymatic reactions, obliterates acetylation of the acceptor antibiotic. Furthermore, when added to amikacin-containing culture medium in complex to ionophores such as pyrithione (ZnPT), it prevents the growth of resistant strains. An undesired property of ZnPT is its poor water-solubility, a problem that currently affects a large percentage of newly designed drugs. Water-solubility helps drugs to dissolve in body fluids and be transported to the target location. We tested a pyrithione derivative described previously (Magda et al. Cancer Res 68:5318–5325, 2008) that contains the amphoteric group di(ethyleneglycol)-methyl ether at position 5 (compound 5002), a modification that enhances the solubility. Compound 5002 in complex with zinc (Zn5002) was tested to assess growth inhibition of amikacin-resistant Acinetobacter baumannii and Klebsiella pneumoniae strains in the presence of the antibiotic. Zn5002 complexes in combination with amikacin at different concentrations completely inhibited growth of the tested strains. However, the concentrations needed to achieve growth inhibition were higher than those required to achieve the same results using ZnPT. Time-kill assays showed that the effect of the combination amikacin/Zn5002 was bactericidal. These results indicate that derivatives of pyrithione with enhanced water-solubility, a property that would make them drugs with better bioavailability and absorption, are a viable option for designing inhibitors of the resistance to amikacin mediated by AAC(6')-Ib, an enzyme commonly found in the clinics.
Multimodal feature fusion based on object relation for video captioning
Authors: Yan Zhiwen , Chen Ying , Song Jinlong , Zhu Jia 
Published: January 2022

AbstractVideo captioning aims at automatically generating a natural language caption to describe the content of a video. However, most of the existing methods in the video captioning task ignore the relationship between objects in the video and the correlation between multimodal features, and they also ignore the effect of caption length on the task. This study proposes a novel video captioning framework (ORMF) based on the object relation graph and multimodal feature fusion. ORMF uses the similarity and Spatio‐temporal relationship of objects in video to construct object relation features graph and introduce graph convolution network (GCN) to encode the object relation. At the same time, ORMF also constructs a multimodal features fusion network to learn the relationship between different modal features. The multimodal feature fusion network is used to fuse the features of different modals. Furthermore, the proposed model calculates the length loss of the caption, making the caption get richer information. The experimental results on two public datasets (Microsoft video captioning corpus [MSVD] and Microsoft research‐video to text [MSR‐VTT]) demonstrate the effectiveness of our method.
Demonstration of an optical phase conjugation based dual‐hop PDM‐QPSK free‐space optical communication link
Authors: Chen Junfan , Yu Zhaoxin , Wang Tianshu , Liu Zhi , Gao Shiming 
Published: January 2022

AbstractThe dual‐hop free‐space optical (FSO) communication link for polarization‐division multiplexing quadrature phase‐shift keying (PDM‐QPSK) signals is proposed and experimentally demonstrated in an atmospheric chamber with the optical phase conjugation (OPC) compensating the turbulence‐induced signal distortions. The phase fluctuations can be effectively reduced by the OPC, as the error vector magnitudes are 10.03% and 8.28% decreased for x‐ and y‐polarization. At the bit error rate of 1 × 10–3, the power penalty of the dual‐hop link with OPC is 2.85 or 2.34 dB lower than that of each polarization without OPC.
The eROSITA Final Equatorial-Depth Survey (eFEDS)
Authors: Ramos-Ceja M. E. , Oguri M. , Miyazaki S. , Ghirardini V. , Chiu I. , Okabe N. , Liu A. , Schrabback T. , Akino D. , Bahar Y. E. , Bulbul E. , Clerc N. , Comparat J. , Grandis S. , Klein M. , Lin Y.-T. , Merloni A. , Mitsuishi I. , Miyatake H. , More S. , Nandra K. , Nishizawa A. J. , Ota N. , Pacaud F. , Reiprich T. H. , Sanders J. S. 
Published: January 2022

Context.The eFEDS survey is a proof-of-concept mini-survey designed to demonstrate the survey science capabilities of SRG/eROSITA. It covers an area of 140 deg2where ~540 galaxy clusters have been detected out to a redshift of 1.3. The eFEDS field is partly embedded in the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) S19A data release, which covers ~510 deg2, containing approximately 36 million galaxies. This galaxy catalogue has been used to construct a sample of ~180 shear-selected galaxy clusters. The common area to both surveys covers about 90 deg2, making it an ideal region to study galaxy clusters selected in different ways.Aims.The aim of this work is to investigate the effects of selection methods in the galaxy cluster detection by comparing the X-ray selected, eFEDS, and the shear-selected, HSC-SSP S19A, galaxy cluster samples. There are 25 shear-selected clusters in the eFEDS fooprint.Methods.The relation between X-ray bolometric luminosity and weak-lensing mass is investigated (Lbol-Mrelation), comparing this relation derived from a shear-selected cluster sample to the relation obtained from an X-ray selected sample. Moreover, the dynamical state of the shear-selected clusters is investigated and compared to the X-ray selected sample using X-ray morphological parameters and galaxy distribution.Results.The normalisation of theLbol– M relation of the X-ray selected and shear-selected samples is consistent within 1σ-. Moreover, the dynamical state and merger fraction of the shear-selected clusters is not different from the X-ray selected ones. Four shear-selected clusters are undetected in X-rays. A close inspection reveals that one is the result of projection effects, while the other three have an X-ray flux below the ultimate eROSITA detection limit. Finally, 43% of the shear-selected clusters lie in superclusters.Conclusions.Our results indicate that the scaling relation between X-ray bolometric luminosity and true cluster mass of the shear-selected cluster sample is consistent with the eFEDS sample. There is no significant population of X-ray underluminous clusters, indicating that X-ray selected cluster samples are complete and can be used as an accurate cosmological probe.