bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Assimilating High‐Resolution Atmospheric Motion Vectors on Convective Scale Short‐Term Forecasts: 3. Experiments With Radar Reflectivity and Radial Velocity
Authors: Zhao Juan , Gao Jidong , Jones Thomas , Hu Junjun 
Published: November 2022

AbstractBased on the idealized supercell and real case studies in Part I and II, the purpose of this subsequent study is to further investigate the impact of assimilating Geostationary Operational Environmental Satellites‐16 (GOES‐16) derived atmospheric motion vectors (AMVs) in addition to WSR_88D Doppler radar observations on convective scale numerical weather prediction. Five high‐impact weather events that occurred in spring 2018 and 2019 are analyzed using the National Severe Storms Laboratory three‐dimensional variational data assimilation (DA) system. Four types of experiments are implemented and compared: (a) the control experiment (NoDA) without assimilating any observation, (b) the radar DA experiment (RAD), (c) the GOES‐16 AMV DA experiment (AMV), and (d) the experiment assimilating AMVs together with radar data (AMV_RAD). Score metrics aggregated over all cases indicate that AMV_RAD performs slightly better than RAD in 0–3 hr reflectivity and precipitation forecasts especially at higher thresholds, suggesting the added value of GOES‐16 AMVs on radar data. Detailed case examinations also show that AMV_RAD generally exhibits slightly more skillful storm forecast in terms of the areal coverage, storm mode, and storm orientations, owing to improvements in the analysis of boundary locations and localized enhanced divergence signatures. In spite of encouraging objective and subjective evaluation results, AMV_RAD has difficulty in adjusting the moisture gradient associated with dryline and tends to underpredict the associated weak discrete storms.
PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ
Authors: Yang Qinyu , Lu Ying , Shangguan Jianfang , Shu Xu 
Published: November 2022

AbstractThe deubiquitinating enzyme family in tumor progression play important role in intracellular protein degradation. The proteasome subunit alpha type 1 (PSMA1) has been reported to act as an oncogene in several human cancers. The present study aimed to reveal the functional significance of PSMA1 in gastric cancer (GC) progression and the underlying mechanisms. The expression of PSMA1 in human GC samples and GC cell lines was examined by western blot analysis, real-time PCR, immunohistochemistry (IHC), and in vitro ubiquitination assays and established a xenograft mouse model. We found that PSMA1 was upregulated in GC and promoted proliferation, migration and invasion in GC cells. Herein, we report transcriptional co-activator with PDZ-binding motif (TAZ) was a downstream gene of PSMA1. Mechanistically, PSMA1 directly interacted with and stabilized TAZ via deubiquitination in GC. Furthermore, we found that TAZ was the essential mediator of PSMA1-modulated oncogenic activity in vitro and in vivo. Examination of clinical samples confirmed that elevated mediators of PSMA1, concomitant with increased TAZ abundance, correlate with human GC progression. These data suggested that PSMA1 promotes GC progression and proliferation by deubiquitinating TAZ. PSMA1 promotes GC progression and proliferation regarding PSMA1-mediated deubiquitinating enzyme activity and suggest potential therapeutic targets for GC management.
The more you do it, the easier it gets: using behaviour change theory to support health care professionals offering reproductive genetic carrier screening
Authors: Best Stephanie , Long Janet C. , Fehlberg Zoe , Theodorou Tahlia , Hatem Sarah , Archibald Alison , Braithwaite Jeffrey 
Published: November 2022

AbstractRecent advances in genomic sequencing have improved the accessibility of reproductive genetic carrier screening (RGCS). As awareness and interest grows, non-genetic health care professionals are increasingly offering RGCS to consumers. We conducted a qualitative interview study informed by behaviour change theory to identify influences on health care professionals considered as ‘early adopters’ offering RGCS through Mackenzie’s Mission, an Australian national research study investigating the implementation of free RGCS to couple’s preconception or in early pregnancy. Interviews were deductively analysed using the Theoretical Domains Framework to examine barriers and enabling factors. In total, we interviewed 31 health care professionals, who were primarily general practitioners (n = 23) offering RGCS through Mackenzie’s Mission. Upon analysis, 15 barriers and 44 enablers to implementation were identified and categorised across three health care professional target behaviours 1. Engaging with RGCS, 2. Identifying eligible patients, and 3. Offering RGCS. Whilst all Theoretical Domains Framework domains were present, barriers were predominantly categorised as ‘Environmental Context and Resources’ e.g., lack of time, followed by ‘Knowledge’ e.g., lack of understanding about genetics and ‘Beliefs about Capabilities’ e.g., concern about giving high risk results to patients. Although health care professionals expressed a preference for offering RGCS through a comprehensive and supported model of care, such as Mackenzie’s Mission, barriers remain. By understanding what drives current health care professionals’ behaviour towards offering RGCS, behaviour change theory provides an avenue to direct future efforts based on evidence and improve service delivery.
Rapid atom-efficient polyolefin plastics hydrogenolysis mediated by a well-defined single-site electrophilic/cationic organo-zirconium catalyst
Authors: Mason Alexander H. , Motta Alessandro , Das Anusheela , Ma Qing , Bedzyk Michael J. , Kratish Yosi , Marks Tobin J. 
Published: November 2022

AbstractPolyolefins comprise a major fraction of single-use plastics, yet their catalytic deconstruction/recycling has proven challenging due to their inert saturated hydrocarbon connectivities. Here a very electrophilic, formally cationic earth-abundant single-site organozirconium catalyst chemisorbed on a highly Brønsted acidic sulfated alumina support and characterized by a broad array of experimental and theoretical techniques, is shown to mediate the rapid hydrogenolytic cleavage of molecular and macromolecular saturated hydrocarbons under mild conditions, with catalytic onset as low as 90 °C/0.5 atm H2 with 0.02 mol% catalyst loading. For polyethylene, quantitative hydrogenolysis to light hydrocarbons proceeds within 48 min with an activity of > 4000 mol(CH2 units)·mol(Zr)−1·h−1 at 200 °C/2 atm H2 pressure. Under similar solventless conditions, polyethylene-co−1-octene, isotactic polypropylene, and a post-consumer food container cap are rapidly hydrogenolyzed to low molecular mass hydrocarbons. Regarding mechanism, theory and experiment identify a turnover-limiting C-C scission pathway involving ß-alkyl transfer rather than the more common σ-bond metathesis.
Breakup of the proton halo nucleus 8B near barrier energies
Authors: Yang L. , Lin C. J. , Yamaguchi H. , Moro A. M. , Ma N. R. , Wang D. X. , Cook K. J. , Mazzocco M. , Wen P. W. , Hayakawa S. , Wang J. S. , Yang Y. Y. , Zhang G. L. , Huang Z. , Inoue A. , Jia H. M. , Kahl D. , Kim A. , Kwag M. S. , Commara M. La , Gu G. M. , Okamoto S. , Parascandolo C. , Pierroutsakou D. , Shimizu H. , Sun H. H. , Wang M. L. , Yang F. , Zhong F. P. 
Published: November 2022

AbstractThe dynamics of a nuclear open quantum system could be revealed in the correlations between the breakup fragments of halo nuclei. The breakup mechanism of a proton halo nuclear system is of particular interest as the Coulomb polarization may play an important role, which, however, remains an open question. Here we use a highly efficient silicon detector array and measure the correlations between the breakup fragments of 8B incident on 120Sn at near-barrier energies. The energy and angular correlations can be explained by a fully quantum mechanical method based on the state-of-the-art continuum discretized coupled channel calculations. The results indicate that, compared to the neutron halo nucleus 6He, 8B presents distinctive reaction dynamics: the dominance of the elastic breakup. This breakup occurs mainly via the short-lived continuum states, almost exhausts the 7Be yield, indicating the effect of Coulomb polarization on the proton halo state. The correlation information reveals that the prompt breakup mechanism dominates, occurring predominantly on the outgoing trajectory. We also show that, as a large environment, the continuum of 8B breakup may not significantly influence elastic scattering and complete fusion.
High thermal conductivity in wafer-scale cubic silicon carbide crystals
Authors: Cheng Zhe , Liang Jianbo , Kawamura Keisuke , Zhou Hao , Asamura Hidetoshi , Uratani Hiroki , Tiwari Janak , Graham Samuel , Ohno Yutaka , Nagai Yasuyoshi , Feng Tianli , Shigekawa Naoteru , Cahill David G. 
Published: November 2022

AbstractHigh thermal conductivity electronic materials are critical components for high-performance electronic and photonic devices as both active functional materials and thermal management materials. We report an isotropic high thermal conductivity exceeding 500 W m−1K−1 at room temperature in high-quality wafer-scale cubic silicon carbide (3C-SiC) crystals, which is the second highest among large crystals (only surpassed by diamond). Furthermore, the corresponding 3C-SiC thin films are found to have record-high in-plane and cross-plane thermal conductivity, even higher than diamond thin films with equivalent thicknesses. Our results resolve a long-standing puzzle that the literature values of thermal conductivity for 3C-SiC are lower than the structurally more complex 6H-SiC. We show that the observed high thermal conductivity in this work arises from the high purity and high crystal quality of 3C-SiC crystals which avoids the exceptionally strong defect-phonon scatterings. Moreover, 3C-SiC is a SiC polytype which can be epitaxially grown on Si. We show that the measured 3C-SiC-Si thermal boundary conductance is among the highest for semiconductor interfaces. These findings provide insights for fundamental phonon transport mechanisms, and suggest that 3C-SiC is an excellent wide-bandgap semiconductor for applications of next-generation power electronics as both active components and substrates.
Correlated color temperature is not a suitable proxy for the biological potency of light
Authors: Esposito Tony , Houser Kevin 
Published: November 2022

AbstractUsing a simulation based on a real, five-channel tunable LED lighting system, we show that Correlated Color Temperature (CCT) is not a reasonable predictor of the biological potency of light, whether characterized with CIE melanopic Equivalent Daylight Illuminance (mel-EDI), Equivalent Melanopic Lux (EML) (a scalar multiple of mel-EDI), or Circadian Stimulus (CS). At a photopic corneal illuminance of 300 lx and Rf ≥ 70, spectra can vary in CS from 17 to 41% across CCTs from 2500 to 6000 K, and up to 23% at a single CCT, due to the choice of spectrum alone. The CS range is largest, and notably discontinuous, at a CCT of 3500 K, the location of the inflection point of the CS model. At a photopic corneal illuminance of 300 lx and Rf ≥ 70, mel-EDI can vary from 123 to 354 lx across CCTs from 2500 to 6000 K and can vary by up to 123 lx at a fixed CCT (e.g., 196 to 319 lx at 5000 K). The range of achievable mel-EDI increases as CCT increases and, on average, decreases as color fidelity, characterized with IES TM-30 Rf, increases. These data demonstrate that there is no easy mathematical conversion between CS and mel-EDI when a spectrally diverse spectra set of spectral power distributions is considered.
Theoretical designing of non-fullerene derived organic heterocyclic compounds with enhanced nonlinear optical amplitude: a DFT based prediction
Authors: Khalid Muhammad , Khan Mashal , Mahmood Khalid , Arshad Muhammad , Imran Muhammad , Braga Ataualpa Albert Carmo , Hussain Riaz 
Published: November 2022

AbstractIn current era, non-fullerene (NF) chromophores have been reported as significant NLO materials due to promising optoelectronic properties. Therefore, a series of NF based chromophores abbreviated as TPBD2-TPBD6 with D–π–A architecture was designed from the reference compound (TPBR1) by its structural tailoring with an efficient donor and various acceptor groups for the first time. First, the structures of said compounds were optimized at M06-2X/6-311G (d,p) level. Further, the optimized structures were utilized to execute frontier molecular orbitals (FMOs), UV–Visible (UV–Vis) absorption, density of states (DOS) and transition density matrix (TDM) analyses at the same level to understand the non-linear (NLO) response of TPBR1 and TPBD2-TPBD6. Promising NLO results were achieved for all derivatives i.e., the highest amplitude of linear polarizability ⟨α⟩, first (βtotal) and second ($$\gamma$$
γ
total) hyperpolarizabilities than their parent molecule. The compound TPBD3 was noted with the most significant NLO properties as compared to the standard molecule. The structural modeling approach by utilizing the acceptor molecules has played a prominent role in attaining favorable NLO responses in the molecules. Thus, our study has tempted the experimentalists to synthesize the proposed NLO materials for the modern optoelectronic high-tech applications.
Fractal fractional analysis of non linear electro osmotic flow with cadmium telluride nanoparticles
Authors: Murtaza Saqib , Kumam Poom , Kaewkhao Attapol , Khan Naveed , Ahmad Zubair 
Published: November 2022

AbstractNumerical simulations of non-linear Casson nanofluid flow were carried out in a microchannel using the fractal-fractional flow model. The nano-liquid is prepared by dispersing Cadmium Telluride nanoparticles in common engine oil. Using relative constitutive equations, the system of mathematical governing equations has been formulated along with initial and boundary conditions. Dimensionless variables have been used to obtain the non-dimensional form of the governing equations. The fractal-fractional model has been obtained by employing the fractal-fractional operator of the exponential kernel. As the exact solution of the non-linear fractal-fractional model is very tough to find, therefore the formulated model has been solved numerically via the Crank-Nicolson scheme. Various plots are generated for the inserted parameters. From the analysis, it has been observed that a greater magnitude of the electro-kinetic parameter slows down the fluid's velocity. It is also worth noting that the fractional and classical models can also be derived from the fractal-fractional model by taking the parameters tend to zero. From the analysis, it is also observed that in response to 0.04 volume fraction of cadmium telluride nanoparticles, the rate of heat transfer (Nusselt number) and rate of mass transfer (Sherwood number) increased by 15.27% and 2.07% respectively.
Association of COVID-19 with diabetes: a systematic review and meta-analysis
Authors: Ssentongo Paddy , Zhang Yue , Witmer Lisa , Chinchilli Vernon M. , Ba Djibril M. 
Published: November 2022

AbstractEmerging evidence suggests that coronavirus disease-2019 (COVID-19) may lead to a wide range of post-acute sequelae outcomes, including new onset of diabetes. The aim of this meta-analysis was to estimate the incidence of newly diagnosed diabetes in survivors of COVID-19. We searched MEDLINE, Scopus, Cochrane Central Register of Controlled Trials and the World Health Organization Global Literature on Coronavirus Disease and clinical trial registries for studies reporting the association of COVID-19 and diabetes. Search dates were December 2019–October 16, 2022. Two investigators independently assessed studies for inclusion. Risk of bias was assessed using the Newcastle–Ottawa Scale. We estimated the effect of COVID-19 on incident diabetes by random-effects meta-analyses using the generic inverse variance method. We identified 8 eligible studies consisting of 4,270,747 COVID-19 patients and 43,203,759 controls. Median age was 43 years (interquartile range, IQR 35–49), and 50% were female. COVID-19 was associated with a 66% higher risk of incident diabetes (risk ratio, 1.66; 95% CI 1.38; 2.00). The risk was not modified by age, sex, or study quality. The median risk of bias assessment was 7. In this systematic review and meta-analysis, COVID-19 was associated with higher risk for developing new onset diabetes among survivors. Active monitoring of glucose dysregulation after recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is warranted.
Inflammatory biomarkers and pendelluft magnitude in ards patients transitioning from controlled to partial support ventilation
Authors: Cornejo Rodrigo A. , Arellano Daniel H. , Ruiz-Rudolph Pablo , Guiñez Dannette V. , Morais Caio C. A. , Gajardo Abraham I. J. , Lazo Marioli T. , Brito Roberto E. , Cerda María A. , González Sedric J. , Rojas Verónica A. , Diaz Gonzalo A. , López Lorena D. M. , Medel Juan N. , Soto Dagoberto I. , Bruhn Alejandro R. , Amato Marcelo B. P. , Estuardo Nivia R. 
Published: November 2022

AbstractThe transition from controlled to partial support ventilation is a challenge in acute respiratory distress syndrome (ARDS) patients due to the risks of patient-self-inflicted lung injury. The magnitude of tidal volume (VT) and intrapulmonary dyssynchrony (pendelluft) are suggested mechanisms of lung injury. We conducted a prospective, observational, physiological study in a tertiary academic intensive care unit. ARDS patients transitioning from controlled to partial support ventilation were included. On these, we evaluated the association between changes in inflammatory biomarkers and esophageal pressure swing (ΔPes), transpulmonary driving pressure (ΔPL), VT, and pendelluft. Pendelluft was defined as the percentage of the tidal volume that moves from the non-dependent to the dependent lung region during inspiration, and its frequency at different thresholds (− 15, − 20 and − 25%) was also registered. Blood concentrations of inflammatory biomarkers (IL-6, IL-8, TNF-α, ANGPT2, RAGE, IL-18, Caspase-1) were measured before (T0) and after 4-h (T4) of partial support ventilation. Pendelluft, ΔPes, ΔPL and VT were recorded. Nine out of twenty-four patients (37.5%) showed a pendelluft mean ≥ 10%. The mean values of ΔPes, ΔPL, and VT were − 8.4 [− 6.7; − 10.2] cmH2O, 15.2 [12.3–16.5] cmH2O and 8.1 [7.3–8.9] m/kg PBW, respectively. Significant associations were observed between the frequency of high-magnitude pendelluft and IL-8, IL-18, and Caspase-1 changes (T0/T4 ratio). These results suggest that the frequency of high magnitude pendelluft may be a potential determinant of inflammatory response related to inspiratory efforts in ARDS patients transitioning to partial support ventilation. Future studies are needed to confirm these results.
Winding-to-ground fault location in power transformer windings using combination of discrete wavelet transform and back-propagation neural network
Authors: Chiradeja Pathomthat , Ngaopitakkul Atthapol 
Published: November 2022

AbstractPower transformers are important equipment in power systems and require a responsive and accurate protection system to ensure system reliability. In this paper, a fault location algorithm for power transformers based on the discrete wavelet transform and back-propagation neural network is presented. The system is modelled on part of Thailand’s transmission and distribution system. The ATP/EMTP software is used to simulate fault signals to validate the proposed algorithm, and the performance is evaluated under various conditions. In addition, various activation functions in the hidden and output layers are compared to select suitable functions for the algorithm. Test results show that the proposed algorithm can correctly locate faults on the transformer winding under different conditions with an average error of less than 0.1%. This result demonstrates the feasibility of implementing the proposed algorithm in actual protection systems for power transformers.
Moderate and transient impact of antibiotic use on the gut microbiota in a rural Vietnamese cohort
Authors: Bich Vu Thi Ngoc , Le Ngoc Giang , Barnett David , Chan Jiyang , van Best Niels , Tien Tran Dac , Anh Nguyen Thi Hien , Hoang Tran Huy , van Doorn H. Rogier , Wertheim Heiman F. L. , Penders John 
Published: November 2022

AbstractThe human gut microbiota has been shown to be significantly perturbed by antibiotic use, while recovering to the pre-treatment state several weeks after short antibiotic exposure. The effects of antibiotics on the gut microbiota have however been mainly documented in high-income settings with lower levels of antibiotic resistance as compared to lower and middle income countries (LMIC). This study aimed to examine the long-term consequences of repeated exposure to commonly use antibiotics on the fecal microbiota of residents living in a low income setting with high prevalence of antibiotic resistance. Fecal samples from household individuals (n = 63) participating in a rural cohort in northern Vietnam were collected monthly for a period of 6 months. Using 16S V4 rRNA gene region amplicon sequencing and linear mixed-effects models analysis, we observed only a minor and transient effect of antibiotics on the microbial richness (ß = − 31.3, 95%CI = − 55.3, − 7.3, p = 0.011), while the microbial diversity was even less affected (ß = − 0.298, 95%CI − 0.686, 0.090, p = 0.132). Principal Component Analyses (PCA) did not reveal separation of samples into distinct microbiota-based clusters by antibiotics use, suggesting the microbiota composition was not affected by the antibiotics commonly used in this population. Additionally, the fecal microbial diversity of the subjects in our study cohort was lower when compared to that of healthy Dutch adults (median 3.95 (IQR 3.72–4.13) vs median 3.69 (IQR3.31–4.11), p = 0.028, despite the higher dietary fiber content in the Vietnamese as compared to western diet. Our findings support the hypothesis that frequent antibiotic exposure may push the microbiota to a different steady state that is less diverse but more resilient to disruption by subsequent antibiotic use.
Diagnostic performance of two non-invasive biomarkers used individually and in sequential combination for cirrhosis associated with hepatitis C virus infection
Authors: Suan Mohd Azri Mohd , Chan Huan Keat , Sem Xiaohui , Shilton Sonjelle , Hassan Muhammad Radzi Abu 
Published: November 2022

AbstractThis cross-sectional study evaluated the performance of the Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) and the Fibrosis-4 (FIB-4) Index when they were used individually and in sequential combination to diagnose cirrhosis associated with hepatitis C virus infection. The final evaluation involved 906 people living with hepatitis C. The diagnostic performance of individual biomarkers at cut-off scores of 1.5 and 2.0 for the APRI and at 3.25 for the FIB-4 index was assessed. For the sequential combination method, the cirrhosis status of individuals with an APRI score between 1.0 and 1.5 were reassessed using the FIB-4. Transient elastography (TE) was used as the reference standard for diagnosing cirrhosis. The APRI, at a cut-off score of 1.5, showed a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 44.9%, 97.6%, 91.1% and 76.3%, respectively. Increasing the cut-off score to 2.0 produced a much lower sensitivity (29.6%) and NPV (71.9%). The FIB-4, at a cut-off score of 3.25, yielded a sensitivity, specificity, PPV and NPV of 40.8%, 97.3%, 89.1% and 75.0%, respectively. The sequential combination method demonstrated a much more optimal diagnostic performance (50.2% sensitivity, 96.6% specificity, 89.0% PPV and 77.9% NPV). Overall, the APRI and FIB-4 Index performed better in diagnosing cirrhosis associated with hepatitis C when they were used in sequential combination.