bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a flatter ontology of institutional logics: How logics relate in situations of institutional complexity
Authors: Mountford Nicola , Cai Yuzhuo 
Published: August 2022

AbstractThe institutional logics approach is a powerful lens with which to examine and understand contexts in which norms and conceptions are multiple, unclear or in flux. While logics at the societal level have been well elaborated and are, in the most part, widely understood and accepted, at the field level logics are not necessarily so clear. Field frames distort, merge and confuse the societal logic as field actors negotiate, rebalance, bridge and interpret logics in a recursively constitutive process. We review research in two institutionally complex fields—higher education and healthcare ‐ that employs an institutional logics lens. We identify and categorize institutional logics arising in these two fields and ask how these field‐level logics relate to each other and to societal‐level ideal‐type logics. We ask what roles ideologies play in mediating relations between the field‐level logics and what are the mechanisms by which this happens. We find that, at the field level, societal logics can appear as field‐level instantiations or merge to form hybrids. New field‐level logics can also emerge, but often these are confused with ideologies, thus limiting the theory‐building potential of the institutional logics approach. We identify and begin to resolve confusion between logics and ideologies, highlighting the role of ideologies in mediating the relationships between logics at the field level. We advocate for, and pave the way towards, a new research agenda enabled by a flatter ontology of institutional logics that sees a horizontal relationship between logics as well as a vertical relationship between logics and actors.
Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets
Authors: Badimon Lina , Padro Teresa , Arderiu Gemma , Vilahur Gemma , Borrell‐Pages Maria , Suades Rosa 
Published: August 2022

SummaryAtherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular bioactive cargoes and play essential roles in intercellular communication and, hence, a multifaceted role in health and disease. The present review offers a glimpse into the current state and up‐to‐date concepts on EV field. It also covers their association with several cardiovascular risk factors and ischemic conditions, being subclinical atherosclerosis of utmost relevance for prevention. Interestingly, we show that EVs hold promise as prognostic and diagnostic as well as predictive markers of ASCVD in the precision medicine era. We then report on the role of EVs in atherothrombosis, disentangling the mechanisms involved in the initiation, progression, and complication of atherosclerosis and showing their direct effect in the context of arterial thrombosis. Finally, their potential use for therapeutic intervention is highlighted.
Paraneoplastic pemphigus: A detailed case series from the Netherlands revealing atypical cases
Authors: Zaheri Farhat , Pas Hendri H. , Bremer Jeroen , Meijer Joost M. , Bolling Marieke C. , Horvath Barbara , Diercks Gilles F. H. 
Published: August 2022

AbstractBackgroundParaneoplastic pemphigus (PNP) is an extremely rare life‐threatening blistering autoimmune disease that is associated with an underlying neoplasm. There is a set diagnostic criterion for PNP, which is primarily based on a severe stomatitis and the detection of specific antibodies against envoplakin, periplakin and alpha‐2‐macroglobulin‐like protein 1. However, it has become increasingly evident that there are patients with PNP that do not meet all the diagnostic criteria requirements.ObjectivesThe aim of this study was to analyse our cohort of Dutch patients and to define the atypical cases that did not meet the diagnostic criteria.MethodsA retrospective case study of all known Dutch PNP patients of the past 25 years. Patients' clinical and immunological variables were thoroughly analysed and described.ResultsTwenty‐four patients were included in this study. The results revealed several atypical patient cases that did not completely meet the set diagnostic criteria. Of the 24 patients, two patients presented without stomatitis, in three patients an underlying neoplasm could not be detected, and in two patients the presence of specific autoantibodies could not be demonstrated, although all other criteria for PNP were met. Finally, three of the 24 patients survived the disease.ConclusionAlthough our findings showed similarities to previous studies and most of the patients met the criteria, there were a few atypical patient cases; highlighting the importance of not strictly adhering to the set criteria when making a diagnosis, as this can lead to a missed or late diagnosis. Thus, it is of crucial importance to combine clinical and elaborate laboratory results to confirm the diagnosis of PNP in suspected patients. Although PNP harbours an unfavourable prognosis in most cases, it might be resolved by timely treatment of the underlying cause.
Impact of endoscopic surveillance on mortality of metachronous esophageal and head and neck cancer after esophageal endoscopic resection
Authors: Matsueda Katsunori , Ishihara Ryu , Morishima Toshitaka , Okubo Yuki , Kawakami Yushi , Sakurai Hirohisa , Nakamura Takahiko , Tani Yasuhiro , Miyake Muneaki , Shichijo Satoki , Maekawa Akira , Kanesaka Takashi , Yamamoto Sachiko , Takeuchi Yoji , Higashino Koji , Uedo Noriya , Michida Tomoki , Matsunaga Takashi , Ohno Yuko , Sobue Tomotaka , Miyashiro Isao 
Published: August 2022

AbstractBackground and AimAs more superficial esophageal cancer (EC) patients are being treated with endoscopic resection (ER), it is important to understand the outcomes, including survival data, of patients who develop metachronous EC and head and neck cancer (HNC). We aimed to evaluate the long‐term surveillance and survival outcomes of metachronous EC and HNC after esophageal ER.MethodsThis study included 627 patients who underwent ER of superficial esophageal squamous cell carcinoma from 2008 to 2016 and were generally followed by annual or biannual esophagogastroduodenoscopy up to 2019 at Osaka International Cancer Institute. Data on metachronous cancer development and causes of death were collected from an integrated database of hospital‐based cancer registry and Vital Statistics of Japan.ResultsDuring a median (range) follow‐up period of 67.4 (3.8–142.7) months, 230 patients (36.7%) developed 500 metachronous ECs and 126 patients (20.1%) developed 239 metachronous HNCs, post‐ER of index EC. The 3‐year, 5‐year, and 7‐year cumulative incidences were 25.8%, 36.0%, and 43.6% for metachronous EC and 10.9%, 16.0%, and 26.9% for metachronous HNC, respectively. No patients died of metachronous EC, and only seven patients (1.1%) died of metachronous HNC. The 3‐year, 5‐year, and 7‐year disease‐specific survival rates were 99.8%, 99.6%, and 98.6%, respectively.ConclusionsThe incidences of metachronous EC and HNC increase with time over 5 years after esophageal ER; therefore, surveillance endoscopy should be continued over 5 years. Endoscopic surveillance is useful for survivors after esophageal ER given the high incidence and extremely low mortality of metachronous EC and HNC.
Baby‐led weaning: A thematic analysis of comments made by parents using online parenting forums
Authors: Pearce Jo , Rundle Rachel 
Published: August 2022

AbstractBackgroundBaby‐led weaning (BLW) centres on making the baby an active partner, rather than a passive recipient of complementary feeding. Key features of BLW include self‐feeding foods in their natural form, eating with the rest of the family and consuming family foods. This differs from traditional weaning (TW) where parents initially spoon feed purees, alongside finger foods, before graduating to more textured food. Previous research, however, has suggested parents may not fully adhere to one weaning style. The present study aimed to explore how the meaning and interpretation of BLW may contribute to the weaning style used.MethodsMessages and responses posted on three UK parenting forums, and relating to complementary feeding, were analysed using an interpretive thematic approach.ResultsThe characterisation of BLW by parents was varied, although they described BLW having an ethos which included trusting the baby, role modelling, developing confidence with food and sharing the social aspects of mealtimes. BLW also offered an alternative to those actively seeking something different or a default for those whose baby refused purees or spoon feeding. BLW felt like a natural progression, with low parental effort for some, and a source of anxiety, stress, choking risk and mess for others. Many parents struggled to find a process (what to eat and when) within BLW that they could follow. Finger foods were used synonymously with BLW, but many mixed/blurred aspects of both TW and BLW.ConclusionsThe interpretation of BLW varies considerably between parents and a broader definition of BLW may be required, along with guidance on the process and purpose of BLW.
Construction and validation of postoperative hypothermia prediction model for patients undergoing joint replacement surgery
Authors: Li Leilei , Lu Yubing , Yang Li Li , Xu Wei , Yu Jing Kai 
Published: August 2022

AbstractAimTo construct and validate a postoperative hypothermia prediction model for patients undergoing joint replacement surgery.BackgroundPostoperative hypothermia is one of the harmful perioperative complications in patients undergoing joint replacement surgery. The previous studies mainly focused on intraoperative hypothermia prediction models. The prediction model for postoperative hypothermia in patients with joint replacement surgery was understudied.DesignCohort study.MethodsWe collected data from 503 participants undergoing joint replacement surgery in a tertiary hospital from January 2019 to December 2021. Of those, 404 cases were assigned to the modelling and 99 to the validation groups. Logistic regression was used to construct the model. The AUC was used to test the predictive effect of the model. Finally, 99 cases were used to verify the application effect of the model. A TRIPOD checklist was used to guide the reporting of this study.ResultsThe factors entered into the prediction model were age, intraoperative hypothermia, BMI, heat preservation measures and platelet (PLT). The model was constructed as follows: Logit (P) = .537 + 3.669 × 1 (intraoperative hypothermia) + .030 × age − .289 × BMI + 2.857 × 1 (intraoperative insulation measures) + .003 × PLT. Hosmer–Lemeshow test, p = .608, the area under the receiver operating characteristic curve (AUC) was .861. The Youden index was .530, the sensitivity was .599 and the specificity was .93. The incidence of postoperative hypothermia in the modelling group was 42.93% (173/404), and that in the verification group was 43.43% (43/99), χ2 = .012, p = .912. The correct practical application rate was 87.88%. This model has a good application effect.ConclusionThe current prediction model provided a reference for clinical screening of patients with high‐risk hypothermia after joint replacement surgery.Relevance to clinical practiceClinical nurses can use the developed prediction model to predict the occurrence of postoperative hypothermia and provide a reference for the preventive measure.
Usefulness of implementing the OHIP‐14 questionnaire to assess the impact of xerostomia and hyposalivation on quality of life in patients with primary Sjögren's syndrome
Authors: Serrano Julia , López‐Pintor Rosa María , Fernández‐Castro Mónica , Ramírez Lucía , Sanz Mariano , López Javier , Blázquez María Ángeles , González Jorge Juan , Hernández Gonzalo ,   EPOX‐SSp Group
Published: August 2022

AbstractBackgroundThe aim of this study is to analyze if the results of the Oral Health Impact Profile‐14 questionnaire (OHIP‐14) in patients with primary Sjögren's syndrome (pSS) are correlated with salivary flow and level of xerostomia.MethodsThis observational cross‐sectional study was conducted in 61 patients (60 women, one man, mean age 57.64 [13.52]) diagnosed of pSS according to the American‐European Criteria (2002). After recording demographic, medical and dental data (decayed‐missing‐filled teeth index [DMFT]), unstimulated (UWS) and stimulated (SWS) salivary flows were collected. Subsequently, UWS flow was categorized into two groups (<0.1 ml/min and ≥0.1 ml/min) and SWS into three groups (<0.1 ml/min, 0.1–0.7 ml/min and >0.7 ml/min). Patients also filled out a visual analog scale (VAS) for xerostomia and OHIP‐14 for self‐reported quality of life (QoL).ResultsData showed positive and significant correlation between OHIP‐14 and xerostomia, based on VAS results (r = 0.52; p = 0.001). Furthermore, there was a negative correlation between UWS and OHIP‐14 scores (r = −0.34; p = 0.006) and VAS for xerostomia (r = −0.22; p = 0.09). No significant correlation was found between SWS and OHIP‐14 or VAS neither between DMFT and OHIP‐14. When assessing the level of QoL by the UWS and SWS flow categories a significant association was found for UWS (p = 0.001) but not for SWS (p = 0.11). The OHIP‐14 values were higher in the groups with lower salivary flow. The multiple linear regression to predict OHIP‐14 only selected VAS for xerostomia as a statistically significant predictor.ConclusionsIncreased level of xerostomia and reduced UWS flow decrease oral health‐related QoL in patients with pSS.
Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors
Authors: Posa Luca , De Gregorio Danilo , Lopez‐Canul Martha , He Qianzi , Darcq Emmanuel , Rullo Laura , Pearl‐Dowler Leora , Luongo Livio , Candeletti Sanzio , Romualdi Patrizia , Kieffer Brigitte Lina , Gobbi Gabriella 
Published: August 2022

AbstractMelatonin, through its G protein‐coupled receptor (GPCR) (MTNR1B gene) MT2, is implicated in analgesia, but the relationship between MT2 receptors and the opioid system remains elusive. In a model of rodent neuropathic pain (spared nerve injured [SNI]), the selective melatonin MT2 agonist UCM924 reversed the allodynia (a pain response to a non‐noxious stimulus), and this effect was nullified by the pharmacological blockade or genetic inactivation of the mu opioid receptor (MOR), but not the delta opioid receptor (DOR). Indeed, SNI MOR, but not DOR knockout mice, did not respond to the antiallodynic effects of the UCM924. Similarly, the nonselective opioid antagonist naloxone and the selective MOR antagonist D‐Phe‐Cys‐Tyr‐D‐Trp‐Orn‐Thr‐Pen‐Thr‐NH2 (CTOP) blocked the effects of UCM924 in SNI rats, but not the DOR antagonist naltrindole (NTI). Electrophysiological recordings in the rostral‐ventromedial medulla (RVM) revealed that the typical reduction of the firing activity of pronociceptive ON‐cells, and the enhancement of the firing of the antinociceptive OFF‐cells, induced by the microinjection of the MT2 agonist UCM924 into the ventrolateral periaqueductal gray (vlPAG) were blocked by MOR, but not DOR, antagonism. Immunohistochemistry studies showed that MT2 receptors are expressed in both excitatory (CaMKIIα+) and inhibitory (GAD65+) neuronal cell bodies in the vlPAG (~2.16% total), but not RVM. Only 0.20% of vlPAG neurons coexpressed MOR and MT2 receptors. Finally, UCM924 treatment induced an increase in the enkephalin precursor gene (PENK) in the PAG of SNI mice. Collectively, the melatonin MT2 receptor agonism requires MORs to exert its antiallodynic effects, mostly through an interneuronal circuit involving MOR and MT2 receptors.
The chondrite breccia of Antonin (L4‐5)—A new meteorite fall from Poland with a heterogeneous distribution of metal
Authors: Bischoff Addi , Patzek Markus , Peters Stefan T. M. , Barrat Jean‐Alix , Di Rocco Tommaso , Pack Andreas , Ebert Samuel , Jansen Christian A. , Kmieciak Kryspin 
Published: August 2022

AbstractOn July 15, 2021, a huge fireball was visible over Poland. After the possible strewn field was calculated, the first and so far only sample, with a mass of 350 g, was discovered 18 days after the fireball event. The Antonin meteorite was found August 3, 2021, on the edge of a forest close to a dirt road near Helenow, a small suburb of the city of Mikstat. The rock is an ordinary chondrite breccia and consists of equilibrated and recrystallized lithologies. The boundaries between different fragments are difficult to detect, and the lithologies are of petrologic type 5 and type 4. The rock is moderately shocked (S4) and contains local impact melt areas and thin shock veins. The low‐Ca pyroxene and olivine are equilibrated (Fs20.6and Fa24.0, respectively), typical of L chondrites. The L chondrite classification is also supported by O isotope data and the results of bulk chemical analysis. The Ti isotope characteristics confirm that Antonin is related to the noncarbonaceous (NC) meteorites. One of the studied thin sections shows an unusual metal–chondrule assemblage, perhaps indicating that the metal in the chondrite is heterogeneously distributed, which is, however, not clearly visible in the element abundances.
Current understanding of atrial fibrillation recurrence after atrial fibrillation ablation: From pulmonary vein to epicardium
Authors: Lu Yu , Zei Paul C. , Jiang Chenyang 
Published: August 2022

AbstractRecurrence of atrial fibrillation (AF) after catheter ablation is common, with pulmonary vein (PV) reconnection considered the most likely cause. However, technologies such as contact force‐sensing, irrigated catheters, and ablation index (AI)‐guided ablation strategies have resulted in more durable PV isolation. As a result, it is difficult to predict which patients will develop AF recurrence despite durable PV isolation, with evolving non‐PV atrial substrates thought to be a key contributor to late recurrences. Deciphering the complex mechanisms of AF recurrence beyond the cornerstone of PV isolation therefore remains challenging. Recently, there have been several important advances that may lead to better understanding and treatment of this challenging clinical entity: percutaneous epicardial access and mapping, late gadolinium enhancement magnetic resonance imaging (LGE‐MRI), improvements in high‐resolution electroanatomic mapping, and new ablation energy sources, specifically pulsed‐field ablation. This review aims to synthesize the current literature in an effort to better understand arrhythmia mechanisms and treatment targets in patients with AF/Atrial tachycardia (AT) recurrence post‐ablation.
Capturing Protein–Nucleic Acid Interactions by High‐Intensity Laser‐Induced Covalent Cross‐Linking†
Authors: Angelov Dimitar , Boopathi Ramachandran , Lone Imtiaz Nisar , Menoni Hervé , Dimitrov Stefan , Cadet Jean 
Published: August 2022

ABSTRACTInteractions of DNA with structural proteins such as histones, regulatory proteins and enzymes play a crucial role in major cellular processes such as transcription, replication and repair. The in vivo mapping and characterization of the binding sites of the involved biomolecules are of primary importance for a better understanding of genomic deployment that is implicated in tissue and developmental stage‐specific gene expression regulation. The most powerful and commonly used approach to date is immunoprecipitation of chemically cross‐linked chromatin (XChIP) coupled with sequencing analysis (ChIP‐seq). While the resolution and the sensitivity of the high‐throughput sequencing techniques have been constantly improved, little progress has been achieved in the cross‐linking step. Because of its low efficiency, the use of the conventional UVC lamps remains very limited while the formaldehyde method was established as the “gold standard” cross‐linking agent. Efficient biphotonic cross‐linking of directly interacting nucleic acid–protein complexes by a single short UV laser pulse has been introduced as an innovative technique for overcoming limitations of conventionally used chemical and photochemical approaches. In this survey, the main available methods including the laser approach are critically reviewed for their ability to generate DNA–protein cross‐links in vitro model systems and cells.
Optimal specialty crop planning policies with yield learning and forward contract
Authors: Chen Heng , Ryan Jennifer K. 
Published: August 2022

Hops are the flowers of a specialty crop that provide unique flavors to craft beer. We study a multi‐year crop planning problem for a farmer who seeks to add hops production to the current production of a conventional crop. The farmer must dynamically determine the number of acres to allocate to each crop and design the terms of the forward contract under which brewers purchase the hops, considering the uncertainty of weather conditions, hops yield, hops spot market price, and conventional crop price. We formulate a multi‐period stochastic dynamic programming framework that incorporates statistical learning methods that depend on exogenous factors. We also develop an easy‐to‐implement learning‐based marginal total profit heuristic which can potentially be used as a decision support tool. Our numerical analyses suggest that yield learning is particularly important for a farmer who is considering investing in a high margin, but potentially risky, new crop such as hops. We also characterize the conditions under which yield learning is most beneficial for farmers. This paper contributes to the literature on specialty crop planning by introducing a multi‐year planning framework that incorporates unique characteristics of specialty crop production. We fill a gap in the crop planning literature by considering how farmers can learn about crop yields based on realized yields and exogenous factors such as weather conditions. Our paper is also of practical importance for farmers who seek to diversify their crop portfolio to hedge against risks associated with trade tensions and potential price drops for conventional crops.
Soybean cultivars adapted to southern Brazil differ in their reaction to Globisporangium irregulare, G. ultimum var. sporangiiferum and Pythium conidiophorum
Authors: Molin Cleisla , Ribeiro Neucimara Rodrigues , Matsumoto Marcos Norio , Brollo Joel , Bordignon Kelen , dos Santos de Britto Julia , Balbinotti Maicon , Barbieri Maurício , Deuner Carolina Cardoso , Huzar‐Novakowiski Jaqueline 
Published: August 2022

AbstractIn Brazil there is little information on the reaction of soybean cultivars to Globisporangium and Pythium species that can cause damping‐off. Thus, the objective of this study was to characterize the reactions to Globisporangium irregulare isolate UPFOM03, G. ultimum var. sporangiiferum isolate UPFPAN06 and Pythium conidiophorum isolate UPFSA03 of 50 cultivars adapted to southern Brazil. The experiment was carried out twice in a randomized complete block design with three replications. A root rot assay was performed in a growth chamber and emergence (%), emergence speed index (ESI), total dry mass per seedling (TDM; g) and root rot severity index (RRSI) were determined. There was a significant (p < 0.05) difference among the cultivars on all the variables. The least susceptible cultivars to G. irregulare were BRS 5804, BMX Compacta, FPS 1867, BMX Fibra, BMX Apolo, M6410, M6210, BMX Elite and BRS 5601. However, the least susceptible cultivars to G. ultimum var. sporangiiferum were M6410, M6210, BMX Tornado, NS 6601, NS 5258, NS 6909, BMX Fibra, FPS 1954, M5917, BMX Delta, FPS 1867, BMX Cromo, NEO 610, BMX Elite, DM 61i59, BMX Apolo, BMX Compacta and M5947. Thirty‐six soybean cultivars were less susceptible to P. conidiophorum, which was also less aggressive than G. irregulare and G. ultimum var. sporangiiferum. In conclusion, there are some soybean cultivars that are less susceptible to the three oomycete isolates and should be preferred in fields with a history of damping‐off.