bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a novel FGFR2-KIAA1217 fusion in esophageal gastrointestinal stromal tumours: A case report
Authors: Luo Yuehao , Wu Ying , Chang Xiaona , Huang Bo , Luo Danju , Zhang Jiwei , Zhang Peng , Shi Heshui , Fan Jun , Nie Xiu 
Published: August 2022

BackgroundGastrointestinal stromal tumours (GISTs) rarely arise in the esophagus. The clinical course and treatment options for esophageal GISTs are poorly understood because of their rarity. In general, the mutation spectrum of esophageal GISTs resembles that of gastric GISTs. Wild-type (WT) GISTs lacking KIT and PDGFRA gene mutations occasionally occur in adults; primary esophageal GISTs are commonly WT.Case presentationHerein, we report the case of a 41-year-old female patient who presented with a 1-week history of anterior upper chest pain. Chest computed tomography revealed a 3.7 cm × 2.8 cm × 6.7 cm soft tissue mass in the right posterior mediastinum adjacent to the esophagus. The patient underwent thoracoscopic mediastinal tumor resection and was subsequently diagnosed with an esophageal GIST. Neither KIT nor PDGFRA mutations were detected by Sanger sequencing; however, next-generation sequencing (NGS) identified an FGFR2-KIAA1217 gene fusion in the tumor tissue. No relapse was observed in this patient during the 8-month treatment-free follow-up period.ConclusionTo the best of our knowledge, this report is the first to describe an FGFR2-KIAA1217 fusion in a patient with a quadruple WT esophageal GIST. When WT KIT/PDGFRA GISTS are suspected, intensive genetic analysis is recommended, and obtaining a better molecular characterization of these tumours might reveal novel therapeutic avenues.
Digital quantitative tissue image analysis of hypoxia in resected pancreatic ductal adenocarcinomas
Authors: Siddiqui Iram , Bilkey Jade , McKee Trevor D. , Serra Stefano , Pintilie Melania , Do Trevor , Xu Jing , Tsao Ming-Sound , Gallinger Steve , Hill Richard P. , Hedley David W. , Dhani Neesha C. 
Published: August 2022

BackgroundTumor hypoxia is theorized to contribute to the aggressive biology of pancreatic ductal adenocarcinoma (PDAC). We previously reported that hypoxia correlated with rapid tumor growth and metastasis in patient-derived xenografts. Anticipating a prognostic relevance of hypoxia in patient tumors, we developed protocols for automated semi-quantitative image analysis to provide an objective, observer-independent measure of hypoxia. We further validated this method which can reproducibly estimate pimonidazole-detectable hypoxia in a high-through put manner.MethodsWe studied the performance of three automated image analysis platforms in scoring pimonidazole-detectable hypoxia in resected PDAC (n = 10) in a cohort of patients enrolled in PIMO-PANC. Multiple stained tumor sections were analyzed on three independent image-analysis platforms, Aperio Genie (AG), Definiens Tissue Studio (TS), and Definiens Developer (DD), which comprised of a customized rule set.ResultsThe output from Aperio Genie (AG) had good concordance with manual scoring, but the workflow was resource-intensive and not suited for high-throughput analysis. TS analysis had high levels of variability related to misclassification of cells class, while the customized rule set of DD had a high level of reliability with an intraclass coefficient of more than 85%.DiscussionThis work demonstrates the feasibility of developing a robust, high-performance pipeline for an automated, quantitative scoring of pimonidazole-detectable hypoxia in patient tumors.
The CURB65 score predicted 180-day mortality of non-small cell lung carcinoma patients with immune checkpoint inhibitor-associated pneumonitis: A pilot retrospective analysis
Authors: Lan Fen , Fan Bo , Wang Lihua , Xia Lixia , Zhang Ting , Li Wen , Mao Yanxiong 
Published: August 2022

IntroductionThe immune checkpoint inhibitor-associated pneumonitis (CIP) is a particularly worrisome and potentially lethal form of immune-related adverse events. An objective and evidence-based assessment tool for evaluating the severity of CIP is in urgent need. CURB65 (consciousness, urea nitrogen, respiratory rate, blood pressure, and age) is a potential candidate to meet the need.MethodsA retrospective study was conducted to explore preliminarily if CURB65 could predict the mortality in non-small cell lung carcinoma (NSCLC) patients with CIP.ResultsA total number of 28 NSCLC patients with CIP were included in the current study and classified into low-CURB65 group (n = 21) and high-CURB65 group (n = 7). Mortality after onset of CIP was consistently higher in the high-CURB65 group than in the low-CURB65 group (30-day: 57.1% vs. 0; 90-day: 71.4% vs. 4.76%; 180-day:71.4% vs. 14.29%). Two patients (9.5%) in the low-CURB65 group had severe CIP, and more than half of patients in the high-CURB65 group had severe CIP (p = 0.0008). The patients in the high-CURB65 group received more aggressive treatment. Both groups showed a predominant organizing pneumonia-like pattern on CT scan. CURB65 was moderately correlated with the American Society of Clinical Oncology (ASCO) grade of CIP, with a Pearson correlation coefficient R of 0.524.ConclusionCURB65 accurately stratified the risk of mortality in NSCLC patients with CIP. CURB65 might complement the ASCO grade in the assessment and prediction of mortality in these populations.
Thermal servo-controlled systems in the management of VLBW infants at birth: A systematic review
Authors: Ercolino Orietta , Baccin Erica , Alfier Fiorenza , Villani Paolo Ernesto , Trevisanuto Daniele , Cavallin Francesco 
Published: August 2022

BackgroundThermal management of the newborn at birth remains an actual challenge. This systematic review aimed to summarize current evidence on the use of thermal servo-controlled systems during stabilization of preterm and VLBW infants immediately at birth.MethodsA comprehensive search was conducted including MEDLINE/Pubmed, EMBASE, SCOPUS, clinicaltrials.gov, and the Cochrane Database through December 2021. PRISMA guidelines were followed. Risk of bias was appraised using Cochrane RoB2 and Risk Of Bias In Non-Randomized Studies of Interventions (ROBIN-I) tools, and certainty of evidence using GRADE framework.ResultsOne randomized controlled trial and one observational study were included. Some aspects precluded the feasibility of a meaningful meta-analysis; hence, a qualitative review was conducted. Risk of bias was low in the trial and serious in the observational study. In the trial, the servo-controlled system did not affect normothermia (36.5–37.5°C) but was associated with increased mild hypothermia (from 22.2 to 32.9%). In the observational study, normothermia (36–38°C) increased after the introduction of the servo-controlled system and the extension to larger VLBW infants.ConclusionOverall, this review found very limited information on the use of thermal servo-controlled systems during stabilization of preterm and VLBW infants immediately at birth. Further research is needed to investigate the opportunity of including such approach in the neonatal thermal management in delivery room.RegistrationPROSPERO (CRD42022309323).
Monogenic developmental and epileptic encephalopathies of infancy and childhood, a population cohort from Norway
Authors: Stenshorne Ida , Syvertsen Marte , Ramm-Pettersen Anette , Henning Susanne , Weatherup Elisabeth , Bjørnstad Alf , Brüggemann Natalia , Spetalen Torstein , Selmer Kaja K. , Koht Jeanette 
Published: August 2022

IntroductionDevelopmental and epileptic encephalopathies (DEE) is a group of epilepsies where the epileptic activity, seizures and the underlying neurobiology contributes to cognitive and behavioral impairments. Uncovering the causes of DEE is important in order to develop guidelines for treatment and follow-up. The aim of the present study was to describe the clinical picture and to identify genetic causes in a patient cohort with DEE without known etiology, from a Norwegian regional hospital.MethodsSystematic searches of medical records were performed at Drammen Hospital, Vestre Viken Health Trust, to identify patients with epilepsy in the period 1999–2018. Medical records were reviewed to identify patients with DEE of unknown cause. In 2018, patients were also recruited consecutively from treating physicians. All patients underwent thorough clinical evaluation and updated genetic diagnostic analyses.ResultsFifty-five of 2,225 patients with epilepsy had DEE of unknown etiology. Disease-causing genetic variants were found in 15/33 (45%) included patients. Three had potentially treatable metabolic disorders (SLC2A1, COQ4 and SLC6A8). Developmental comorbidity was higher in the group with a genetic diagnosis, compared to those who remained undiagnosed. Five novel variants in known genes were found, and the patient phenotypes are described.ConclusionThe results from this study illustrate the importance of performing updated genetic investigations and/or analyses in patients with DEE of unknown etiology. A genetic cause was identified in 45% of the patients, and three of these patients had potentially treatable conditions where available targeted therapy may improve patient outcome.
Silver-Nanoparticle- and Silver-Nitrate-Induced Antioxidant Disbalance, Molecular Damage, and Histochemical Change on the Land Slug (Lehmannia nyctelia) Using Multibiomarkers
Authors: Bakr Zeinab , Said Shimaa Mohamed , Mohammad Wafaa A. , Aboulnasr Gehad N. , Elshimy Naser A. 
Published: August 2022

It is known that silver nanoparticles (Ag NPs) and AgNO3 have harmful effects on the surrounding organisms, which may cause damage to these organisms. Therefore, the aim of this study is to detect damage caused by Ag NPs and silver nitrate to land slugs (Lehmannia nyctelia). In this study, the slugs were exposed to various concentrations of Ag NPs and AgNO3 for 15 days. The biochemical, antioxidant, lipid peroxidation (LPO), DNA fragmentation, and histopathological endpoints were assessed after 15 days of exposure to different concentrations of Ag NPs (0.04, 0.08, 0.4, and 0.8 g/L) and silver nitrate (0.04, 0.08, 0.4, and 0.8 g/L). The results show a significant decrease in total protein, total carbohydrate, superoxide dismutase, and GST and a significant increase in total lipid, LPO, and DNA fragmentation after exposure to Ag NPs and AgNO3 for 15 days compared with the control group. Histopathiological alterations were observed in the digestive glands which were indicated by histochemical staining. We concluded that exposure to AgNO3 and Ag NPs caused oxidative stress, genetic damage and alterations in the profile of muscle proteins and histological structure in L. nyctelia.
Implementing psychosocial interventions within low and middle-income countries to improve community-based care for people with psychosis—A situation analysis
Authors: Bird Victoria Jane , Davis Syjo , Jawed Abeer , Qureshi Onaiza , Ramachandran Padmavati , Shahab Areeba , Venkatraman Lakshmi 
Published: August 2022

BackgroundGlobally, a treatment gap exists for individuals with severe mental illness, with 75% of people with psychosis failing to receive appropriate care. This is most pronounced in low and middle-income countries, where there are neither the financial nor human resources to provide high-quality community-based care. Low-cost, evidence-based interventions are urgently needed to address this treatment gap.AimTo conduct a situation analysis to (i) describe the provision of psychosocial interventions within the context of existing care in two LMICs-India and Pakistan, and (ii) understand the barriers and facilitators of delivering a new psychosocial intervention.MethodA situation analysis including a quantitative survey and individual interviews with clinicians, patients and caregivers was conducted. Quantitative survey data was collected from staff members at 11 sites (private and government run hospitals) to assess organizational readiness to implement a new psychosocial intervention. To obtain in-depth information, 24 stakeholders including clinicians and service managers were interviewed about the typical care they provide and/or receive, and their experience of either accessing or delivering psychosocial interventions. This was triangulated by six interviews with carer and patient representatives.Results and discussionThe results highlight the positive views toward psychosocial interventions within routine care and the enthusiasm for multidisciplinary working. However, barriers to implementation such as clinician time, individual attitudes toward psychosocial interventions and organizational concerns including the lack of space within the facility were highlighted. Such barriers need to be taken into consideration when designing how best to implement and sustain new psychosocial interventions for the community treatment of psychosis within LMICs.
A multidisciplinary effort to increase COVID-19 vaccination among the older adults
Authors: Moosa Aminath S. , Wee Yi M. S. , Jaw Meng H. , Tan Qifan F. , Tse Wan L. D. , Loke Chui Y. , Ee Guan L. A. , Ng Chee C. D. , Aau Wai K. , Koh Yi L. E. , Tan Ngiap C. 
Published: August 2022

BackgroundCOVID-19 vaccination significantly reduces the risk of infection and its associated morbidity and mortality. However, poor uptake of the COVID-19 vaccination was reported among the high-risk group of older people amidst emerging variants of concern. This community case study reports an outreach program in Singapore, COVE (COVID-19 Vaccination for the Elderly) initiated by healthcare workers in a cluster of primary care clinics. They assessed the vaccine hesitancy among these older persons, addressed their concerns and facilitated their vaccination appointment during a brief phone conversation.MethodTwenty one thousand six hundred and sixty three unvaccinated adults aged ≥60 years were contacted by healthcare worker volunteers over two phases from June to October 2021. In phase I, they contacted adults aged above 70 years over 2 weeks. Adults who were uncontactable in phase I and those aged 60–69 years were sent SMS in phase II. Data were analyzed via descriptive data analysis.ResultsAfter phase 1, 65.5% (n = 5,646/8,617) of older adults had received at least one dose of the COVID-19 vaccine. The respondents expressed intention to vaccinate (39%, n = 3,390), requested to seek further information (25%, n = 2,138), reported access barrier (8%, n = 715), or were concerned of the vaccine adverse effects (3%, n = 288). Vaccination was refused by 24% (n = 2,086) of the respondents. Eventually 60.4% (n = 13,082/21,663) of them were vaccinated 3 months after COVE implementation.ConclusionThe COVE program increased the COVID-19 vaccination uptake of older adults from 84.6 to 96.3%. A person-centric proactive approach by healthcare workers addressed vaccine hesitancy and optimized vaccination. The outreach scheduling of vaccination appointments is key in promoting vaccination uptake among older adults.
Are immigrants more vulnerable to the socioeconomic impact of COVID-19? A cross-sectional study in Amadora Municipality, Lisbon metropolitan area
Authors: O. Martins Maria Rosario , Shaaban Ahmed Nabil , Abecasis Ana , Muggli Zelia , Amado Regina , Vaz Dora , Dias Sara S. , Silva Antonio C. , Fronteira Ines 
Published: August 2022

IntroductionImmigrants carry an extra burden of morbidities and mortalities since the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Pre-existing inequalities among immigrants may threaten their economic wellbeing during the pandemic. This study analyzed the socioeconomic impact of COVID-19 on immigrants and natives living in Amadora, Metropolitan Region of Lisbon and the extent to which preexisting inequalities had been exacerbated during the pandemic.Materials and methodsThis cross-sectional study was conducted in Amadora Municipality, Lisbon Region, through phone interviews and using a structured questionnaire. Data collected in July 2020, included information on a cohort of 420 households, of which 51% were immigrants. To evaluate the socioeconomic position and economic wellbeing changes occurring during the pandemic we estimate crude and adjusted odds ratio (OR) and 95% CI, using Portuguese natives as the reference group.ResultsOverall, 287 (70%) participants responded to the questionnaire, of which 47% are immigrants. Preexisting socioeconomic inequalities were exacerbated during the pandemic. Compared with natives, immigrants were more likely to experience job loss, temporary lay-off, and income loss during the COVID-19 pandemic. Immigrants were also more likely to face several kinds of financial hardship during the pandemic, such as difficulties in buying food, hygiene products, and paying bills.ConclusionTo the best of our knowledge, this study is the first to capture the direct socioeconomic impact of COVID-19 among immigrants and natives in Portugal. It highlights the bidirectional relation between inequalities deeply rooted among immigrants and COVID-19. Socioeconomic inequalities affect local patterns of COVID-19 burden, as confirmed in previous studies, but COVID-19 also has an impact on the economic wellbeing of Amadora immigrants during the pandemic. Urgent policies must be implemented to mitigate the economic burden of COVID-19 among immigrants, namely in Amadora, Lisbon Region.
Patient's decision and experience in the multi-channel appointment context: An empirical study
Authors: Ye Qing , Wu Hong 
Published: August 2022

BackgroundLong waiting time for treatment in the outpatient department has long been a complaint and has influenced patient's experience. It is critical to schedule patients for doctors to reduce patient's waiting time. Nowadays, multi-channel appointment has been provided for patients to get medical services, especially for those with severe illnesses and remote distance. This study aims to explore the factors that influence patient appointment channel choice in the context of multi-channel appointments, and how channel choice affects the waiting time for offline visiting.MethodsWe collected outpatient appointment records from both online and offline appointment channels to conduct our empirical research. The empirical analysis is conducted in two steps. We first analyze the relationship between appointment channel choice and patient's waiting time and then the relationships between three determinants and appointment channel choice. The ordinary least squares and the logistic regression model are used to obtain the empirical results.ResultsOur results show that a patient with an online appointment decision has a shorter consultation waiting time compared with a patient with on-site appointment (β = −0.320,p&lt; 0.001). High-quality resource demand (β = 0.349,p&lt; 0.001), high-severity disease (β = 0.011,p&lt; 0.001), and high non-disease costs (β = 0.039,p&lt; 0.001) create an obvious incentive for patients to make appointmentsviathe Internet. Further, only the effect of non-disease cost on channel choice is lower for patients with multiple visit histories (β = −0.021,p&lt; 0.001).ConclusionsOur study confirms the effect of Internet use on reducing patient's waiting time. Patients consider both health-related risk factors and cost-related risk factors to make decisions on appointment channels. Our study produces several insights, which have implications for channel choice and patient's behavior literature. More importantly, these insights contribute to the design of appointment systems in hospitals.
Research progress of E-cigarette-A bibliometric analysis during 2010–2022
Authors: Hong Shihui , Wu Feng , Yao Wang , Yang Zixuan , Wei Weiguo , Han Zhe , Feng Can , Fan Min 
Published: August 2022

IntroductionElectronic cigarettes have been widely used all over the world. It is not clear what the advantages and disadvantages of a novelty in daily life are that is attracting increasing attention. Up to now, no bibliometric studies on e-cigarettes have been published in databases. Therefore, we are willing to explore directions and research hotspots in this emerging field by using bibliometrics to analyze research areas, publishing countries and institutions, high-output authors, and future trends of e-cigarettes in recent years. Compared with the traditional review, the bibliometric study can provide some information on core journals, articles, researchers, institutions, and countries concentrating on this topic to guide experimentation strategies and funding decisions.MethodsA bibliometric analysis was performed by CiteSpace and VOSviewer up to April 2022 in the core collection of Web of Science. HistCite, VOSviewer, CiteSpace, and the R-based Bibliometrix 4.1.0 packages were used to analyze literature information, including year, journal, country, institute, author, keywords, and co-cited references.ResultsResearch related to e-cigarettes has proliferated since its inception around 2010. A total of 2,302 studies were published in 689 journals by our search method. Nicotine and tobacco research was the most published journal. The most prolific country was the United States, while the most influential institution was Virginia Commonwealth University. Eight of the top ten authors were from the United States. Oxidative stress, high school students, smoking cessation, delivery, behavioral economics, and exposure were the top topics.ConclusionsAs an emerging social phenomenon, research on e-cigarettes has increased significantly over the past decade, particularly from 2015 to 2020. The top three core journals are Nicotine and Tobacco Research, the International Journal of Environmental Research, and Public Health. Eisenberg-Thomas had published numerous articles on e-cigarettes that had been co-cited in many papers. Oxidative stress, high school students, and smoking cessation are the top three areas of e-cigarette-related research, which were also important areas for further investigation.
Effect of mass sports activity on prosocial behavior: A sequential mediation model of flow trait and subjective wellbeing
Authors: Duan Xiyan , Wang Xiaohua , Li Xiaogang , Li Shichen , Zhong Yiping , Bu Te 
Published: August 2022

ObjectivesParticipation in mass sports is one of the most efficient strategies for people to attain physical and mental health in China. Prosocial behavior has a positive effect on social development. This study developed a conceptual model with mass sports activity as the independent variable, prosocial behavior as the dependent variable, and flow trait and subjective wellbeing as the mediating variables.MethodsParticipants (N= 351) completed an online survey. Mass sports activity, flow trait, subjective wellbeing, and prosocial behavior were measured using the physical activity rank scale-3 (PARS-3), short dispositional flow scale (SDFS), index of wellbeing (IWB), and prosocial tendencies measure (PTM), respectively. Descriptive statistics compared differences between sports population (PARS-3, ≥ 36) and non-sports population (PARS-3, &lt;36). Mediation effect was analyzed using the PROCESS (Template, Model 6).ResultsSports population scored significantly higher (allP≤ 0.05) on SDFS, IWB, and PTM than non-sports population. Participation in mass sports stimulated flow trait and thus improved prosocial behavior, with a mediation effect value of 0.061 (95%CI, 0.028–0.104), which accounted for 30.18% of the total effect. Participation in mass sports enhanced subjective wellbeing and thus improved prosocial behavior, with a mediation effect value of 0.044 (95%CI, 0.007–0.090), which accounted for 21.96% of the total effect. Flow trait and subjective wellbeing mediated the relationship between mass sports activity and prosocial behavior in a sequential manner, with a mediation effect value of 0.059 (95%CI, 0.035–0.090), which accounted for 29.23% of the total effect.ConclusionThe preliminary results of the mediation model validated the hypothesized sequential links between mass sports activity, flow trait, subjective wellbeing, and prosocial behavior. Greater participation in mass sports increases the likelihood of prosocial behavior.