bluuebunny/crossref_metadata_2025_split huggingface dataset:
Betaine Regulates the Production of Reactive Oxygen Species Through Wnt10b Signaling in the Liver of Zebrafish
Authors: Li Ao , Gu Yaqi , Zhang Xiuzhen , Yu Hairui , Liu Dongwu , Pang Qiuxiang 
Published: April 2022

When fish are under oxidative stress, levels of reactive oxygen species (ROS) are chronically elevated, which play a crucial role in fish innate immunity. In the present study, the mechanism by which betaine regulates ROS production via Wnt10b/β-catenin signaling was investigated in zebrafish liver. Our results showed that betaine enrichment of diet at 0.1, 0.2 and 0.4 g/kg induced Wnt10b and β-catenin gene expression, but suppressed GSK-3β expression in zebrafish liver. In addition, the content of superoxide anion (O2·−), hydrogen peroxide (H2O2) and hydroxyl radical (·OH) was decreased by all of the experimental betaine treatments. However, betaine enrichment of diet at 0.1, 0.2 and 0.4 g/kg enhanced gene expression and activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and catalase (CAT) in zebrafish liver. In addition, Wnt10b RNA was further interfered in zebrafish, and the results of Wnt10b RNAi indicated that Wnt10b plays a key role in regulating ROS production and antioxidant enzyme activity. In conclusion, betaine can inhibit ROS production in zebrafish liver through the Wnt10b/β-catenin signaling pathway.
Psychometric Properties of the Persian Version of Palliative Care Outcome Scale (POS) in Adult Patients With Cancer
Authors: Sirati Nir Masoud , Rassouli Maryam , Ebadi Abbas , Moosavi Soolmaz , Pakseresht Maryam , Hasan Shiri Fatemeh , Souri Hossein , Nasiri Morteza , Karami Maryam , Fereidouni Armin , Barasteh Salman 
Published: April 2022

BackgroundMeasuring the outcomes of palliative care plays an important role to improve the quality, efficiency, and availability of these services in patients with cancer. Using valid, reliable, and culturally appropriate tools has a considerable role to measure these outcomes. This study aimed to assess the psychometric properties of the translated version of the Palliative care Outcome Scale (POS).MethodsThis methodological study was conducted in two outpatient clinics related to Shohada Tajrish and Baqiyatallah hospitals in Tehran in 2019–2020. The translation was done using the Forward-Backward approach after gaining permission from the developer. Face validity was tested with 10 patients with cancer through cognitive interviewing, as well as content validity with four experts. Construct validity was performed by (n = 203) exploratory factor analysis and confirmation (N = 150). To assess the reliability, internal consistency was assessed by using Cronbach's alpha coefficient, and relative stability was assessed using the interclass correlation coefficient (ICC). Furthermore, interpretability and ceiling and floor effects were assessed.ResultsA total of 353 patients with cancer under palliative care were included in the study. Then, three psychological (30%), physical (12.25%), and social factors (12.08%) with a cumulative variance of 54.34% were extracted in exploratory factor analysis. Confirmatory factor analysis showed that the model has a good fit of information. Cronbach's alpha coefficient for scale was 0.719. Furthermore, the ICC was 0.812. The scale was interpretable, and ceiling and floor effects were 0%.ConclusionPersian version of the POS was evaluated as a valid and reliable tool. Therefore, it can be used by the clinician to monitor the consequences of palliative care in Iranian cancer patients.
Integrated Family Approach in Mental Health Care by Professionals From Adult and Child Mental Health Services: A Qualitative Study
Authors: Stolper Hanna , van Doesum Karin , Steketee Majone 
Published: April 2022

ObjectiveA multiple case-study in which each case was evaluated by adult and child mental health professionals who used an integrated family approach in their treatments. In this approach, treatment focuses on the mental disorders of the parents as well as on the development of the young child and family relationships. This study evaluated the experiences of professionals from adult and child mental health services using this approach. The aim of the study is identifying key elements of this approach, processes involved in treatment, and barriers to its success, with the aim of contributing to the development of practice based integrated mental health care for the whole family.BackgroundParental mental disorders have an impact on parenting and child development. To stop detrimental cascade effects and prevent parent and child from being caught up in the intergenerational transmission of psychopathology, an integrated family approach in mental health care is needed. Methods: A qualitative case study design using a grounded theory approach. Data were collected through 19 group interviews of professionals (N = 37) from adult and infant mental health teams who worked together in the treatment of a family.ResultsProfessionals from the two services were comfortable coping with complexity and felt supported to perform their treatments by staying in touch with each other in multi-disciplinary consultations. They indicated that by attuning the treatment components to each other and tailoring them to the capabilities of the family, their treatments had more impact. A flexible attitude of all involved professionals and commitment to the interest of all family members was essential.ConclusionAccording to professionals, treatment with an integrated family approach in mental health care is of value for families by addressing the distinct roles, positions and relationships, by implementing a flexible complementary treatment plan, and by empowering professionals by multi-disciplinary consultations.
Vocal Acoustic Features as Potential Biomarkers for Identifying/Diagnosing Depression: A Cross-Sectional Study
Authors: Zhao Qing , Fan Hong-Zhen , Li Yan-Li , Liu Lei , Wu Ya-Xue , Zhao Yan-Li , Tian Zhan-Xiao , Wang Zhi-Ren , Tan Yun-Long , Tan Shu-Ping 
Published: April 2022

BackgroundAt present, there is no established biomarker for the diagnosis of depression. Meanwhile, studies show that acoustic features convey emotional information. Therefore, this study explored differences in acoustic characteristics between depressed patients and healthy individuals to investigate whether these characteristics can identify depression.MethodsParticipants included 71 patients diagnosed with depression from a regional hospital in Beijing, China, and 62 normal controls from within the greater community. We assessed the clinical symptoms of depression of all participants using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Patient Health Questionnaire (PHQ-9), and recorded the voice of each participant as they read positive, neutral, and negative texts. OpenSMILE was used to analyze their voice acoustics and extract acoustic characteristics from the recordings.ResultsThere were significant differences between the depression and control groups in all acoustic characteristics (p &lt; 0.05). Several mel-frequency cepstral coefficients (MFCCs), including MFCC2, MFCC3, MFCC8, and MFCC9, differed significantly between different emotion tasks; MFCC4 and MFCC7 correlated positively with PHQ-9 scores, and correlations were stable in all emotion tasks. The zero-crossing rate in positive emotion correlated positively with HAMA total score and HAMA somatic anxiety score (r = 0.31, r = 0.34, respectively), and MFCC9 of neutral emotion correlated negatively with HAMD anxiety/somatization scores (r = −0.34). Linear regression showed that the MFCC7-negative was predictive on the PHQ-9 score (β = 0.90, p = 0.01) and MFCC9-neutral was predictive on HAMD anxiety/somatization score (β = −0.45, p = 0.049). Logistic regression showed a superior discriminant effect, with a discrimination accuracy of 89.66%.ConclusionThe acoustic expression of emotion among patients with depression differs from that of normal controls. Some acoustic characteristics are related to the severity of depressive symptoms and may be objective biomarkers of depression. A systematic method of assessing vocal acoustic characteristics could provide an accurate and discreet means of screening for depression; this method may be used instead of—or in conjunction with—traditional screening methods, as it is not subject to the limitations associated with self-reported assessments wherein subjects may be inclined to provide socially acceptable responses rather than being truthful.
Epilepsy and Molecular Phenotype Affect the Neurodevelopment of Pediatric Angelman Syndrome Patients in China
Authors: Li Shuang , Ma Yu , Wang Tianqi , Jin Huimin , Du Xiaonan , Wang Yi 
Published: April 2022

ObjectiveThis study investigated the mental development of children with Angelman syndrome (AS) in China and evaluated the relationship between neurodevelopment and molecular subtype, age, epilepsy, and sex using the Chinese version of the Griffith Mental Development Scale (GMDS-C) to provide detailed baseline data regarding neurodevelopment with AS in China.MethodsParticipants were recruited from the AS Natural History Study. The GMDS-C was used to evaluate all participants' mental age and developmental quotients. The general quotient (GQ) and quotients of five subscales (sports, personal-social, auditory language, eye-hand coordination, and comprehensive performance) were calculated.ResultsA total of 119 children (average age: 42.12 months; range, 7.5–95.5 months) with a genetic diagnosis of AS were enrolled. The median GQ score of the GMDS was 29.6 points (95% confidence interval, 28.6–33.25). The children had relatively good locomotor and personal-social skills but poor language skills. Overall, 89% (106/119) had mental ages younger than 24 months for all five subscales. The non-deletion group (i.e., without deletion in chromosome 15q11–13) had higher GQs and locomotor, personal-social, and performance subscale quotients. The GQ was significantly different among the three age subgroups and significantly correlated with age. Compared with the non-epilepsy group, the epilepsy group had lower GQs and lower quotients for the locomotor, personal-social, speech, language, and eye-hand coordination subscales.ConclusionChildren with AS in China experience severe neurodevelopmental deterioration. In addition to age, molecular subtypes and the onset of seizures may also correlate with these patients' intellectual development. The GMDS-C is an accurate tool that can assess the clinical characteristics of AS. The data of this study can be used as baseline data for clinical trials performed to evaluate drug development or other AS treatment development.
Usability-Focused Development and Usage of NeoTree-Beta, an App for Newborn Care in a Low-Resource Neonatal Unit, Malawi
Authors: Crehan Caroline , Chiume Msandeni , Mgusha Yamikani , Dinga Precious , Hull-Bailey Tim , Normand Charles , Sassoon Yali , Nkhoma Deliwe , Greenwood Kim , Lorencatto Fabiana , Lakhanpaul Monica , Heys Michelle 
Published: April 2022

BackgroundNeonatal mortality is high in low-resource settings. NeoTree is a digital intervention for neonatal healthcare professionals (HCPs) aiming to achieve data-driven quality improvement and improved neonatal survival in low-resource hospitals. Optimising usability with end-users could help digital health interventions succeed beyond pilot stages in low-resource settings. Usability is the quality of a user's experience when interacting with an intervention, encompassing their effectiveness, efficiency, and overall satisfaction.ObjectiveTo evaluate the usability and usage of NeoTree beta-app and conduct Agile usability-focused intervention development.MethodA real-world pilot of NeoTree beta-app was conducted over 6 months at Kamuzu Central Hospital neonatal unit, Malawi. Prior to deployment, think-aloud interviews were conducted to guide nurses through the app whilst voicing their thoughts aloud (n = 6). System Usability Scale (SUS) scores were collected before the implementation of NeoTree into usual clinical care and 6 months after implementation (n = 8 and 8). During the pilot, real-world user-feedback and user-data were gathered. Feedback notes were subjected to thematic analysis within an Agile “product backlog.” For usage, number of users, user-cadre, proportion of admissions/outcomes recorded digitally, and median app-completion times were calculated.ResultsTwelve overarching usability themes generated 57 app adjustments, 39 (68%) from think aloud analysis and 18 (32%) from the real-world testing. A total of 21 usability themes/issues with corresponding app features were produced and added to the app. Six themes relating to data collection included exhaustiveness of data schema, prevention of errors, ease of progression, efficiency of data entry using shortcuts, navigation of user interface (UI), and relevancy of content. Six themes relating to the clinical care included cohesion with ward process, embedded education, locally coherent language, adaptability of user-interface to available resources, and printout design to facilitate handover. SUS scores were above average (88.1 and 89.4 at 1 and 6 months, respectively). Ninety-three different HCPs of 5 cadres, recorded 1,323 admissions and 1,197 outcomes over 6 months. NeoTree achieved 100% digital coverage of sick neonates admitted. Median completion times were 16 and 8 min for admissions and outcomes, respectively.ConclusionsThis study demonstrates optimisation of a digital health app in a low-resource setting and could inform other similar usability studies apps in similar settings.
Framework for Armature-Based 3D Shape Reconstruction of Sensorized Soft Robots in eXtended Reality
Authors: Borges Elvis I. A. , Rieder Jonas S. I. , Aschenbrenner Doris , Scharff Rob B. N. 
Published: April 2022

Soft robots are typically intended to operate in highly unpredictable and unstructured environments. Although their soft bodies help them to passively conform to their environment, the execution of specific tasks within such environments often requires the help of an operator that supervises the interaction between the robot and its environment and adjusts the actuation inputs in order to successfully execute the task. However, direct observation of the soft robot is often impeded by the environment in which it operates. Therefore, the operator has to depend on a real-time simulation of the soft robot based on the signals from proprioceptive sensors. However, the complicated three-dimensional (3D) configurations of the soft robot can be difficult to interpret using traditional visualization techniques. In this work, we present an open-source framework for real-time 3D reconstruction of soft robots in eXtended Reality (Augmented and Virtual Reality), based on signals from their proprioceptive sensors. This framework has a Robot Operating System (ROS) backbone, allowing for easy integration with existing soft robot control algorithms for intuitive and real-time teleoperation. This approach is demonstrated in Augmented Reality using a Microsoft Hololens device and runs at up to 60 FPS. We explore the influence that system parameters such as mesh density and armature complexity have on the reconstruction's key performance metrics (i.e., speed, scalability). The open-source framework is expected to function as a platform for future research and developments on real-time remote control of soft robots operating in environments that impede direct observation of the robot.
The Impact of Chronic Limb-Threatening Ischemia on Cardiac Surgery
Authors: Wakabayashi Naohiro , Kikuchi Shinsuke , Kuriyama Naoya , Kikuchi Yuta , Tsutsui Masahiro , Ise Hayato , Yoshida Yuri , Uchida Daiki , Koya Atsuhiro , Shirasaka Tomonori , Azuma Nobuyoshi , Kamiya Hiroyuki 
Published: April 2022

PurposeThe effect of chronic limb threatening ischemia (CLTI) on advanced cardiac disease, which requires surgical treatment, has rarely been reported. The purpose of this study was to review the outcomes of cardiac surgery in patients with CLTI and determine the risk factors, with a particular focus on the severity of CLTI.PatientsThe baseline characteristics and outcomes of 33 patients who were treated for CLTI and underwent cardiac surgery were retrospectively analyzed. The states of CLTI were evaluated based on the Wound, Ischemia, and foot Infection (WIfI) classification system, and 33 patients were divided into the low-WIfI group (stages 1–2, n = 13) and high-WIfI group (stages 3–4, n = 20).ResultsThe in-hospital mortality rate was 0% in low-WIfI group and 35% in high-WIfI group (p = 0.027). Postoperative complications, particularly severe infections, occurred more frequently among high-WIfI group than low-WIfI group (70.0% vs. 23.1%, p &lt; 0.01). Multivariable analysis identified foot infection grade as a WIfI classification factor and lower albumin levels as factors significantly associated with postoperative complications. The 1-year and 2-year survival rates were 84.6% and 67.7% in low-WIfI group and 45% and 28.1% in high-WIfI group, respectively (p = 0.011).ConclusionsCardiac surgery in patients with high WIfI stage was an extremely high-risk procedure. In such patients, lowering the WIfI stage by lower extremity revascularization and/or debridement of diseased parts prior to cardiac surgery can be considered.
Worldview Mali dalam Kearifan Tempatan Penganan Iban di Sarawak: Satu Penelitian Warisan Tidak Ketara
Authors: Tugang Noria , Kiyai Gregory 
Published: April 2022

Masyarakat Iban di Sarawak memiliki demensi atau pandangan yang tersendiri dalam menginterprestasi kepercayaan mereka terhadap dunia dan kehidupan. Kepercayaan atau worldview tersebut memiliki nilai yang signifikan dalam manifestasi kebudayaan ketara dan tidak ketara masyarakat Iban. Oleh itu, penyelidikan ini adalah bersifat etnografi yang memfokuskan kepada kepercayaan Mali dalam kearifan tempatan membuat Penganan iaitu sejenis kuih tradisional Iban. Pendekatan penyelidikan ini adalah menggunakan kaedah kualitatif iaitu dengan melakukan kerja lapangan, mendokumentasi dan menemu bual informan yang mempunyai kepakaran dalam budaya Iban. Kawasan penyelidikan iaitu di Lubok Antu, Betong, Sri Aman dan Limbang telah dipilih sebagai lokasi penyelidikan untuk mendapatkan kepelbagaian data dari setiap penempatan geografi masyarakat Iban. Tujuan penyelidikan ini adalah sebagai satu usaha untuk mengarkibkan dan mengkonservasi kepercayaan Mali sebagai sebuah warisan tidak ketara. Hasil dapatan mendapati bahawa, kepercayaan Mali masih menjadi sebuah warisan dalam bentuk kolektif memori dan diamalkan dalam kehidupan masyarakat Iban kini walaupun mereka telah menganuti agama baharu iaitu agama Islam dan Kristian. Melalui penyelidikan ini diharapkan mampu memberikan satu kefahaman yang komprenhensif mengenai adat resam dan kepercayaan masyarakat pribumi di Malaysia, khususnya masyarakat Iban di Sarawak.
Worldview ‘Mali’ in the Local Wisdom of ‘Penganan’ Iban in Sarawak: an Intangible Heritage Study
Abstract: The Iban in Sarawak possessed their own dimension or perspectives in interpreting belief in the world and life. For the Iban, the belief or worldview have significant value in manifesting tangible and intangible culture. Therefore, this is an ethnography studies focus the belief of Mali from the local expertise in making the traditional Iban food Penganan. This study applied the qualitative approach by conducting field work, documentation and interview with informant adept in the Iban culture. The studies sites were Lubok Antu, Betong, Sri Aman and Limbang for the purpose of collecting numerous data from each Iban’s settlement. This study is an effort to archive and conserve the belief of Mali as an intangible culture. The studies have discovered the belief of Mali is still regard as a heritage in the form of collective memory. This belief is still practice by the Iban although they have converted to the new religion of Islam and Christian. It is this studies aspiration to produce a comprehensive understanding concerning the custom and belief of the indigenous community in Malaysia especially the Iban in Sarawak.
Keywords: Custom, Iban, Indigenous Belief, Traditional Culture, Worldview.
Optimization of bread production with linear programming method (case study : CV. Roti Ca)
Authors: Aini Nur' , Khikmawati Emy , Wardana M W 
Published: April 2022

Optimal production is the main goal in a business, which is to achieve maximum profit. CV. Roti Ca is a company engaged in food products. CV. Roti Ca was established since 2011 producing sandwiches and flatbreads with chocolate and green bean flavors. This study aims to determine the optimal combination of products so as to get maximum results using linear programming. The method used in this study is linear programming which can be applied to produce bread with a simplex model in order to obtain the optimum solution so that profits can be achieved. The results showed that the optimal sales obtained by the factory was Rp. 2,084,568,000, and the number of breads that can be produced each month is 2,605,711 pcs with ca 1,185679 pcs of chocolate sandwiches, ca 306,913 pcs of chocolate flatbread and 1.131,119 pcs of green bean flatbread.Â Keywords: Linear Programming Method, Simplex Method, Optimization, Bread, Qm For Windows
REVIEW ARTIKEL : POTENSI JAMU GENDONG KUNCI SURUH SEBAGAI AGEN ANTIKANKER DAN KO-KEMOTERAPI
Authors: Raden Ajeng Nursamtari  , Ade Zuhrotun  
Published: April 2022

Kanker merupakan penyakit mematikan sekaligus penyebab kematian paling tinggi di dunia. Untuk mengembangkan agen antikanker yang baru, efektif dan dapat mengurangi efek samping dalam penggunaanya maka dikembangkanlah produk menggunakan bahan alami yang mempunyai manfaat terapeutik serta keamanan yang lebih baik. Bahan alami dengan potensi yang menjadi alternatif agen antikanker dan ko-kemoterapi salah satunya adalah jamu gendong kunci suruh. Artikel ini bertujuan untuk memberikan pengetahuan mengenai manfaat lain dari jamu gendong kunci suruhaitu sebagai agen antikanker dan ko-kemoterapi. Pembuatan artikel ini menggunakan metode review artikel. Sumber datanya dengan menggunakan search engine (literatur) yaitu menggunakan PubMed, Mandley, serta Google Scholar. Berdasarkan data ilmiah, khasiat dan efektifitasnya telah dikonfirmasi melalui beberapa penelitian dari jamu gendong kunci suruh dengan formula daun sirih hijau (Piper betle L.),temu kunci (Boesenbergia rotunda) dan kunci pepet (Kaempferia angustifolia). Tanaman tersebut menunjukkan sifat antikanker dengan mekanisme aksi berupa penghambatan proliferasi sel dan induksi apoptosis. Manfaat lain dari jamu gendong kunci suruh adalah sebagai ko-kemoterapi. Pemberian dengan ko-kemoterapi bertujuan untuk mengurangi efek samping yang ditimbulkan oleh obat kemoterapi. Efektivitasnya dalam penggunaan bersama dengan kemoterapi dilaporkan dapat mencapai efek obat yang maksimum, menurunkan viabilitas dan menghasilkan efek sinergis.