bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Eutopian City: The Challenge of Urban Conviviality in the Laudato Si’ and Fratelli Tutti Encyclicals
Authors: de Oliveira Jelson Roberto , Ultramari Clovis 
Published: August 2022

Abstract
This article aims to show how the concept of the eutopian city can be used as a key for reading Pope Francis’s latest two encyclicals (Laudato Si’, from 2015 and Fratelli Tutti, from 2020). We highlight the ideal of conviviality in the notion of common home, political love, and social friendship, whose paradigm in contemporary urban life would be the experience of neighbourhood. This involves thinking of the city as a space of conviviality and the construction of a common project of society, overcoming the divisions of a closed world in favour of an open world. The papal texts therefore reveal formulation of a political proposal precisely at the time when politics was dying, fostered by new climate conditions and the renewed culture of walls.
Public Theology in the Context of the Religious Dualization Phenomenon in Multiple Modernities
Authors: Teixeira Alfredo , Boas Alex Villas , Zeferino Jefferson 
Published: August 2022

Abstract
This article aims to analyze the tasks of public theology concerning the religious phenomenon in a context of multiple modernities. The interaction of religion and public space may take the form of a disjunction between public and private that strengthens the rigid discourse of religious identity against a common project of society. In this context, the place of religion in the public life becomes a significant challenge for public theology. Therefore, in dialogue with the theoretical perspectives of Jürgen Habermas, David Tracy, Michel de Certeau, and Pope Francis, this text proposes a movement towards a complex and interdisciplinary approach that values a shared humanity and responsibility with the common home.
Population Structure and Genetic Diversity in Delphinium (Ranunculaceae) Using Scot Molecular Markers
Authors: LI JUANHUA , ESFANDANI-BOZCHALOYI SOMAYEH 
Published: August 2022

The tribe Delphinieae (Ranunculaceae) comprises two species-rich genera, Aconitum and Delphinium, the latter including Consolida and Aconitella. The 650–700 species are distributed in Eurasia and North America; three species occur on tropical African mountains. Many species of Delphinieae are of horticultural importance or medical use and a few are well-studied in terms of genetic diversity and floral morphology and pollination. We sampled 19 populations from 19 Delphinium species throughout Iran. Start Codon Targeted (SCoT) primer were applied to calculate measures of genetic diversity at the population level and genetic differentiation. Amplification of genomic DNA using 10 primers produced 165 bands, of which 150 were polymorphic (94.48%). The obtained high average PIC and MI values revealed high capacity of SCoT primers to detect polymorphic loci among Delphinium. The genetic similarities of 19 collections were estimated from 0.62 to 0.96. According to the SCoT markers analysis, D. lorestanicum and D. oliganthum had the lowest similarity and the species of D. hohenackeri and D. ajacis had the highest similarity.
“I am African American”: Racial-ethnic self-designation, self-concept, and major depression among African Americans
Authors: Nicholson Harvey L. 
Published: August 2022

Background: Research remains mixed on whether racial-ethnic self-designation impacts psychological health and well-being among Americans of African descent. Existing studies mainly use non-representative samples to address this question. Some scholars argue that Black people who express an African-centered identity should experience improved mental health because it enhances one’s sense of self. However, what role self-designation may have on depression, one of the most common forms of disability, is largely unknown among African Americans. There is also limited evidence on whether one’s self-concept can help us understand the relationship between self-designation and mental health among African Americans. Methods: Using data from a national probability sample of African American adults ( n = 3,329), I examined whether self-designation as African American, Afro-American, Negro, Black American, or some other label versus Black was associated with self-esteem, mastery, and major depressive episodes. Results: Using OLS models, I found that respondents who preferred the terms African American or Afro-American exhibited higher mastery levels compared to individuals who preferred the label Black, the most common term used among respondents. African American identifying respondents also exhibited significantly higher levels of self-esteem compared to Black identifying individuals. Using logistic regression models, I found that only African American identifying respondents were significantly less likely than Black identifying respondents to meet the criteria for major depressive episodes in the past-year. Higher levels of mastery and self-esteem helped to explain such differences. Conclusion: In sum, among Americans of African descent, identification as African American rather than Black may help fight depressive episodes because such self-designation may enhance one’s self-concept. Further research is necessary to explore other possible psychological implications of self-designation among the African American/Black population.
Impact of iodinated contrast media concentration on image quality for dual-energy CT and single-energy CT with low tube voltage settings
Authors: Sookpeng Supawitoo , Martin Colin J 
Published: August 2022

Background Contrast-induced nephropathy (CIN) is an adverse reaction associated with the use of intravenous contrast media (CM). Purpose To investigate the impact of low tube voltage settings on single-energy computed tomography (SECT) and rapid kV switching dual-energy CT (DECT) with reduced concentrations of iodinated CM. Material and Methods A phantom containing four different concentrations of CM (original concentration CM, 20%, 40%, and 60% reductions) was scanned using SECT mode with varying tube voltages (70, 80, 100, and 120 kVp) and DECT mode through reconstructing monoenergetic energy (50 keV and 70 keV) images. ATCM system with different noise index (NI) settings were set, and the images were reconstructed using ASiR-V. Image quality were measured for individual phantom sizes and protocols and compared to a reference protocol for SECT of 120 kVp, NI = 18, threshold contrast enhancement ≥280 HU, and CNR ≥17. Results Tube voltage settings of 70 kVp together with 40% reduction in the iodinated CM is suitable for small phantom size, those of 80 kVp and 20% reduction is suitable for the medium and large sizes. This allows radiation doses to be reduced by 12%–30%. Values of CNR and contrast for DECT are better than those for SECT with the same NI setting. Conclusion Diagnostic reference of image quality can be maintained by using SECT with lower tube voltage and DECT with reductions of iodinated CM concentration and radiation dose. Therefore, the NI setting can be increased when DECT is used to achieve a similar image quality.
Cost-effectiveness of second-line axicabtagene ciloleucel in relapsed refractory diffuse large B-cell lymphoma
Authors: Kambhampati Swetha , Saumoy Monica , Schneider Yecheskel , Serrao Steve , Solaimani Pejman , Budde Lihua Elizabeth , Mei Matthew G. , Popplewell Leslie L. , Siddiqi Tanya , Zain Jasmine , Forman Stephen J. , Kwak Larry W. , Rosen Steven T. , Danilov Alexey V. , Herrera Alex F. , Thiruvengadam Nikhil R. 
Published: August 2022

Abstract
The ZUMA-7 (Efficacy of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma) study showed that axicabtagene ciloleucel (axi-cel) improved event-free survival (EFS) compared with standard of care (SOC) salvage chemoimmunotherapy followed by autologous stem cell transplant in primary refractory/early relapsed diffuse large B-cell lymphoma (DLBCL); this led to its recent US Food and Drug Administration approval in this setting. We modeled a hypothetical cohort of US adults (mean age, 65 years) with primary refractory/early relapsed DLBCL by developing a Markov model (lifetime horizon) to model the cost-effectiveness of second-line axi-cel compared with SOC using a range of plausible long-term outcomes. EFS and OS were estimated from ZUMA-7. Outcome measures were reported in incremental cost-effectiveness ratios, with a willingness-to-pay (WTP) threshold of $150 000 per quality-adjusted life-year (QALY). Assuming a 5-year EFS of 35% with second-line axi-cel and 10% with SOC, axi-cel was cost-effective at a WTP of $150 000 per QALY ($93 547 per QALY). axi-cel was no longer cost-effective if its 5-year EFS was ≤26.4% or if it cost more than $972 061 at a WTP of $150 000. Second-line axi-cel was the cost-effective strategy in 73% of the 10 000 Monte Carlo iterations at a WTP of $150 000. If the absolute benefit in EFS is maintained over time, second-line axi-cel for aggressive relapsed/refractory DLBCL is cost-effective compared with SOC at a WTP of $150 000 per QALY. However, its cost-effectiveness is highly dependent on long-term outcomes. Routine use of second-line chimeric antigen receptor T-cell therapy would add significantly to health care expenditures in the United States (more than $1 billion each year), even when used in a high-risk subpopulation. Further reductions in the cost of chimeric antigen receptor T-cell therapy are needed to be affordable in many regions of the world.
Type 2 inflammation in asthma and other airway diseases
Authors: Maspero Jorge , Adir Yochai , Al-Ahmad Mona , Celis-Preciado Carlos A. , Colodenco Federico D. , Giavina-Bianchi Pedro , Lababidi Hani , Ledanois Olivier , Mahoub Bassam , Perng Diahn-Warng , Vazquez Juan C. , Yorgancioglu Arzu 
Published: August 2022

Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic COPD and allergic rhinitis are a global health concern. Despite the coexistence of these diseases and their common pathophysiology, they are often managed independently, resulting in poor asthma control, continued symptoms and poor quality of life. Understanding disease pathophysiology is important for best treatment practice, reduced disease burden and improved patient outcomes.
The pathophysiology of type 2 inflammation is driven by both the innate immune system triggered by pollutants, viral or fungal infections involving type 2 innate lymphoid cells (ILC2) and the adaptive immune system, triggered by contact with an allergen involving type 2 T-helper (Th2) cells. Both ILC2 and Th2 cells produce the type-2 cytokines (interleukin (IL)-4, IL-5 and IL-13), each with several roles in the inflammation cascade. IL-4 and IL-13 cause B-cell class switching and IgE production, release of pro-inflammatory mediators, barrier disruption and tissue remodelling. In addition, IL-13 causes goblet-cell hyperplasia and mucus production. All three interleukins are involved in trafficking eosinophils to tissues, producing clinical symptoms characteristic of chronic inflammatory airway diseases.
Asthma is a heterogenous disease; therefore, identification of biomarkers and early targeted treatment is critical for patients inadequately managed by inhaled corticosteroids and long-acting β-agonists alone. The Global Initiative for Asthma guidelines recommend add-on biological (anti IgE, IL-5/5R, IL-4R) treatments for those not responding to standard of care. Targeted therapies, including omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab and tezepelumab, were developed on current understanding of the pathophysiology of type 2 inflammation. These therapies offer hope for improved management of type 2 inflammatory airway diseases.
Long COVID headache
Authors: Tana Claudio , Bentivegna Enrico , Cho Soo-Jin , Harriott Andrea M. , García-Azorín David , Labastida-Ramirez Alejandro , Ornello Raffaele , Raffaelli Bianca , Beltrán Eloísa Rubio , Ruscheweyh Ruth , Martelletti Paolo 
Published: August 2022

AbstractHeadache is among the most frequent symptoms persisting or newly developing after coronavirus disease 2019 (COVID-19) as part of the so-called long COVID syndrome. The knowledge on long COVID headache is still limited, however growing evidence is defining the features of this novel condition, in particular regarding clinical characteristics, some pathophysiological mechanisms and first treatment recommendations. Long COVID headache can present in the form of worsening of a preexisting primary headache, or, more specifically, in the form of a new (intermittent or daily) headache starting during the acute infection or after a delay. It often presents together with other long COVID symptoms, most frequently with hyposmia. It can manifest with a migrainous or, more frequently, with a tension-type-like phenotype. Persistent activation of the immune system and trigeminovascular activation are thought to play a role. As there are virtually no treatment studies, treatment currently is largely guided by the existing guidelines for primary headaches with the corresponding phenotype. The present report, a collaborative work of the international group of the Junior Editorial Board of The Journal of Headache and Pain aims to summarize the most recent evidence about long COVID headache and suggests approaches to the diagnosis and treatment of this disorder.

Graphical Abstract
Combining genome size and pollen morphology data to study species relationships in the genus Daucus (Apiaceae)
Authors: Kadluczka Dariusz , Sliwinska Elwira , Grzebelus Ewa 
Published: August 2022

AbstractBackgroundThe genusDaucus(Apiaceae) comprises about 40 wild species and the cultivated carrot, a crop of great economic and nutritional importance. The rich genetic diversity of wildDaucusspecies makes them a valuable gene pool for carrot improvement breeding programs. Therefore, it is essential to have good knowledge of the genome structure and relationships among wildDaucusspecies. To broaden such knowledge, in this research, the nuclear DNA content for 14Daucusaccessions and four closely related species was estimated by flow cytometry and their pollen morphology was analyzed by light and scanning electron microscopy (SEM).ResultsThe flow cytometric analysis showed a 3.2-fold variation in the mean 2C values amongDaucustaxa, ranging from 0.999 (D.carotasubsp.sativus) to 3.228 pg (D.littoralis). Among the outgroup species, the mean 2C values were 1.775–2.882 pg. The pollen grains ofDaucuswere tricolporate, mainly prolate or perprolate (rarely) in shape, and mainly medium or small (rarely) in size (21.19–40.38 µm), whereas the outgroup species had tricolporate, perprolate-shaped, and medium-sized (26.01–49.86 µm) pollen grains. In the studied taxa, SEM analysis revealed that exine ornamentation was striate, rugulate, perforate, or the ornamentation pattern was mixed. At the time of shedding, all pollen grains were three-celled, as evidenced by DAPI staining. We also found high positive correlations between the length of the polar axis (P) and the length of the equatorial diameter (E) of pollen grains, as well as between P and P/E. However, when comparing cytogenetic information with palynological data, no significant correlations were observed.ConclusionsThis study complements the information on the nuclear DNA content inDaucusand provides comprehensive knowledge of the pollen morphology of its taxa. These findings may be important in elucidating the taxonomic relationships amongDaucusspecies and can help in the correct identification of gene bank accessions. In a broader view, they could also be meaningful for the interpretation of evolutionary trends in the genus.
Long-term outcome of a pragmatic trial of multifaceted intervention (STROKE-CARD care) to reduce cardiovascular risk and improve quality-of-life after ischaemic stroke and transient ischaemic attack: study protocol
Authors: Boehme Christian , Domig Lena , Komarek Silvia , Toell Thomas , Mayer Lukas , Dejakum Benjamin , Krebs Stefan , Pechlaner Raimund , Bernegger Alexandra , Mueller Christoph , Rumpold Gerhard , Griesmacher Andrea , Vigl Marion , Schoenherr Gudrun , Schmidauer Christoph , Ferrari Julia , Lang Wilfried , Knoflach Michael , Kiechl Stefan 
Published: August 2022

Abstract
Background
Patients with ischaemic stroke or transient ischaemic attack (TIA) are at high risk of incident cardiovascular events and recurrent stroke. Despite compelling evidence about the efficacy of secondary prevention, a substantial gap exists between risk factor management in real life and that recommended by international guidelines. We conducted the STROKE-CARD trial (NCT02156778), a multifaceted pragmatic disease management program between 2014 and 2018 with follow-up until 2019. This program successfully reduced cardiovascular risk and improved health-related quality of life and functional outcome in patients with acute ischaemic stroke or TIA within 12 months after the index event. To investigate potential long-term effects of STROKE-CARD care compared to standard care, an extension of follow-up is warranted.

Methods
We aim to include all patients from the STROKE-CARD trial (n = 2149) for long-term follow-up between 2019 and 2021 with the study visit scheduled 3–6 years after the stroke/TIA event. The co-primary endpoint is the composite of major recurrent cardiovascular events (nonfatal stroke, nonfatal myocardial infarction, and vascular death) from hospital discharge until the long-term follow-up visit and health-related quality of life measured with the European Quality of Life-5 Dimensions (EQ-5D-3L) at the final visit. Secondary endpoints include overall mortality, long-term functional outcome, and target-level achievement in risk factor management.

Discussion
This long-term follow-up will provide evidence on whether the pragmatic post-stroke/TIA intervention program STROKE-CARD is capable of preventing recurrent cardiovascular events and improving quality-of-life in the long run.
Trial registration clinicaltrials.gov: NCT04205006 on 19 December 2019.
Relationship of arterial tonometry and exercise in patients with chronic heart failure: a systematic review with meta-analysis and trial sequential analysis
Authors: Gong Xiaodan , Hu Mengwen , Li Mei 
Published: August 2022

Abstract
Background
Arterial stiffness is a common characteristic in patients with chronic heart failure (CHF), and arterial tonometric technologies related to arterial stiffness are novel and effective methods and have an important value in the diagnosis and prognosis of CHF. In terms of ameliorating arterial stiffness in patients with CHF, exercise training is considered an adjuvant treatment and also an effective means in the diagnosis and judgment of prognosis. However, there are huge controversies and inconsistencies in these aspects. The objective of this meta-analysis was to systematically test the connection of arterial tonometry and exercise in patients with CHF.

Methods
Databases, including MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, were accessed from inception to 7 March 2022. The meta-analysis was then conducted, and trial sequential analysis (TSA) was performed jointly to further verify our tests and reach more convincing conclusions by using RevMan version 5.4 software, STATA version 16.0 software, and TSA version 0.9.5.10 Beta software.

Results
Eighteen articles were included, with a total of 876 participants satisfying the inclusion criteria. The pooling revealed that flow-mediated dilation (FMD) was lower in basal condition [standardized mean difference (SMD): − 2.28%, 95% confidence interval (CI) − 3.47 to − 1.08, P < 0.001] and improved significantly after exercise (SMD: 5.96%, 95% CI 2.81 to 9.05, P < 0.001) in patients with heart failure with reduced ejection fraction (HFrEF) compared with healthy participants. The high-intensity training exercise was more beneficial (SMD: 2.88%, 95% CI 1.78 to 3.97, P < 0.001) than the moderate-intensity training exercise to improve FMD in patients with CHF. For augmentation index (AIx), our study indicated no significant differences (SMD: 0.50%, 95% CI − 0.05 to 1.05, P = 0.074) in patients with heart failure with preserved ejection fraction (HFpEF) compared with healthy participants. However, other outcomes of our study were not identified after further verification using TSA, and more high-quality studies are needed to reach definitive conclusions in the future.

Conclusions
This review shows that FMD is lower in basal condition and improves significantly after exercise in patients with HFrEF compared with healthy population; high-intensity training exercise is more beneficial than moderate-intensity training exercise to improve FMD in patients with CHF; besides, there are no significant differences in AIx in patients with HFpEF compared with the healthy population. More high-quality studies on this topic are warranted.
Association between dual sensory impairment and risk of mortality: a cohort study from the UK Biobank
Authors: Zhang Xinyu , Wang Yueye , Wang Wei , Hu Wenyi , Shang Xianwen , Liao Huan , Chen Yifan , Kiburg Katerina V. , Huang Yu , Zhang Xueli , Tang Shulin , Yu Honghua , Yang Xiaohong , He Mingguang , Zhu Zhuoting 
Published: August 2022

Abstract
Background
Dual sensory impairment is affecting over 10% of older adults worldwide. However, the long-term effect of dual sensory impairment (DSI) on the risk of mortality remains controversial. We aim to investigate the impact of single or/and dual sensory impairment on the risk of mortality in a large population-based sample of the adult in the UK with 14-years of follow-up.

Methods
This population-based prospective cohort study included participants aged 40 and over with complete records of visual and hearing functions from the UK Biobank study. Measurements of visual and hearing functions were performed at baseline examinations between 2006 and 2010, and data on mortality was obtained by 2021. Dual sensory impairment was defined as concurrent visual and hearing impairments. Cox proportional hazards regression models were employed to evaluate the impact of sensory impairment (dual sensory impairment, single visual or hearing impairment) on the hazard of mortality.

Results
Of the 113,563 participants included in this study, the mean age (standard deviation) was 56.8 (8.09) years, and 61,849 (54.5%) were female. At baseline measurements, there were 733 (0.65%) participants with dual sensory impairment, 2,973 (2.62%) participants with single visual impairment, and 13,560 (11.94%) with single hearing impairment. After a follow-up period of 14 years (mean duration of 11 years), 5,992 (5.28%) participants died from all causes. Compared with no sensory impairment, dual sensory impairment was significantly associated with an estimated 44% higher hazard of mortality (hazard ratio: 1.44 [95% confidence interval, 1.11–1.88], p = 0.007) after multiple adjustments.

Conclusions
Individuals with dual sensory impairment were found to have an independently 44% higher hazard of mortality than those with neither sensory impairment. Timely intervention of sensory impairment and early prevention of its underlying causes should help to reduce the associated risk of mortality.