bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunological Changes in Pregnancy and Prospects of Therapeutic Pla-Xosomes in Adverse Pregnancy Outcomes
Authors: Devvanshi Himadri , Kachhwaha Rohit , Manhswita Anima , Bhatnagar Shinjini , Kshetrapal Pallavi 
Published: April 2022

Stringent balance of the immune system is a key regulatory factor in defining successful implantation, fetal development, and timely parturition. Interference in these primary regulatory mechanisms, either at adolescence or prenatal state led to adverse pregnancy outcomes. Fertility restoration with the help of injectable gonadotrophins/progesterone, ovulation-inducing drugs, immunomodulatory drugs (corticosteroids), and reproductive surgeries provides inadequate responses, which manifest its own side effects. The development of a potential diagnostic biomarker and an effectual treatment for adverse pregnancy outcomes is a prerequisite to maternal and child health. Parent cell originated bi-layered-intraluminal nano-vesicles (30–150 nm) also known as exosomes are detected in all types of bodily fluids like blood, saliva, breast milk, urine, etc. Exosomes being the most biological residual structures with the least cytotoxicity are loaded with cargo in the form of RNAs (miRNAs), proteins (cytokines), hormones (estrogen, progesterone, etc.), cDNAs, and metabolites making them chief molecules of cell-cell communication. Their keen involvement in the regulation of biological processes has portrayed them as the power shots of cues to understand the disease’s pathophysiology and progression. Recent studies have demonstrated the role of immunexosomes (immunomodulating exosomes) in maintaining unwavering immune homeostasis between the mother and developing fetus for a healthy pregnancy. Moreover, the concentration and size of the exosomes are extensively studied in adverse pregnancies like preeclampsia, gestational diabetes mellitus (GDM), and preterm premature rupture of membrane (pPROMs) as an early diagnostic marker, thus giving in-depth information about their pathophysiology. Exosomes have also been engineered physically as well as genetically to enhance their encapsulation efficiency and specificity in therapy for cancer and adverse pregnancies. Successful bench to bedside discoveries and interventions in cancer has motivated developmental biologists to investigate the role of immunexosomes and their active components. Our review summarizes the pre-clinical studies for the use of these power-shots as therapeutic agents. We envisage that these studies will pave the path for the use of immunexosomes in clinical settings for reproductive problems that arise due to immune perturbance in homeostasis either at adolescence or prenatal state.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway
Authors: Guo Jingru , Hu Huijie , Chen Zhuo , Xu Jing , Nie Junshu , Lu Jingjing , Ma Li , Ji Hong , Yuan Jianbin , Xu Bin 
Published: April 2022

Ambient air temperature is a key factor affecting human health. Long-term exposure to a cold environment can cause various diseases, while the impact on the intestine, the organ which has the largest contact area with the external environment, cannot be ignored. In this study, we investigated the effect of chronic cold exposure on the colon and its preliminary mechanism of action. Mice were exposed to 4°C for 3 hours a day for 10 days. We found that cold exposure damaged the morphology and structure of the colon, destroyed the tight junctions of the colonic epithelial tissue, and promoted inflammation of the colon. At the same time, cold exposure also activated the unfolded protein response (UPR) in the colon and promoted apoptosis in intestinal epithelial cells. Chronic cold exposure induced oxidative stress in vivo, but also significantly enhanced the response of the Nrf2 pathway that promotes an anti-oxidant effect. Furthermore, we demonstrated that chronic cold exposure promoted p65 acetylation to aggravate the inflammatory response by inhibiting SIRT1. Similar results were observed following SIRT1 knock-down by shRNA in Caco-2 cells treated with Thapsigargin (Tg). Knock-down of SIRT1 promoted nuclear localization of Nrf2, and increased the level of Nrf2 acetylation. Taken together, our study indicates that cold exposure may aggravate endoplasmic reticulum stress and damage epithelial tight junctions in the colon by inhibiting SIRT1, which promotes nuclear localization of Nrf2 and induces an anti-oxidant response to maintain intestinal homeostasis. These findings suggest that SIRT1 is a potential target for regulating intestinal health under cold exposure conditions.
Road to Tokyo 2020 Olympic Games: Training Characteristics of a World Class Male Triathlete
Authors: Cejuela Roberto , Sellés-Pérez Sergio 
Published: April 2022

There is a growing interest in the scientific literature for reporting top-class endurance athletes training programs. This case study reports on the training program of a world-class male triathlete preparing to compete in the Tokyo 2020 Olympic Games. A macrocycle of 43 weeks is presented. The triathlete performed 14.74 ± 3.01 h of weekly endurance training volume. Training intensity distribution (TID) was 81.93% ± 6.74%/7.16% ± 2.03%/10.91% ± 6.90% for zones 1 (low intensity, &lt;VT1), 2 (moderate intensity, VT1-VT2) and 3 (high intensity, &gt;VT2) respectively. Pyramidal TID model is observed during the initial stages of the periodization and Polarized TID model is observed at the end of the macrocycle. The triathlete’s peak ⩒O2 was increased by 20% on cycling and by 14% on running. Peak power was increased by 3.13% on cycling test and peak speed by 9.71% on running test. Finally, the triathlete placed 12th in Olympic distance and 10th in Mixed Relay in Tokyo 2020 Olympic games.
Early Biomarkers of Altered Renal Function and Orthostatic Intolerance During 10-day Bedrest
Authors: Tamma Grazia , Di Mise Annarita , Ranieri Marianna , Centrone Mariangela , Venneri Maria , D’Agostino Mariagrazia , Ferrulli Angela , Šimunič Boštjan , Narici Marco , Pisot Rado , Valenti Giovanna 
Published: April 2022

Exposure to actual or simulated microgravity results in alterations of renal function, fluid redistribution, and bone loss, which is coupled to a rise of urinary calcium excretion. We provided evidence that high calcium delivery to the collecting duct reduces local Aquaporin 2 (AQP2)-mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration to reduce calcium saturation. To investigate early renal adaptation into simulated microgravity, we investigated the effects of 10 days of strict bedrest in 10 healthy volunteers. We report here that 10 days of inactivity are associated with a transient, significant decrease (day 5) in vasopressin (copeptin) paralleled by a decrease in AQP2 excretion, consistent with an increased central volume to the heart, resulting in reduced water reabsorption. Moreover, bedrest caused a significant increase in calciuria secondary to bone demineralization paralleled by a decrease in PTH. Urinary osteopontin, a glycoprotein exerting a protective effect on stone formation, was significantly reduced during bedrest. Moreover, a significant increase in adrenomedullin (day 5), a peptide with vasodepressor properties, was observed at day 5, which may contribute to the known reduced orthostatic capacity post-bedrest. We conclude that renal function is altered in simulated microgravity and is associated with an early increase in the risk of stone formation and reduced orthostatic capacity post-bedrest within a few days of inactivity.
Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors
Authors: Ho Li-Ting , Serafico Bess Ma. Fabinal , Hsu Ching-En , Chen Zhao-Wei , Lin Tse-Yu , Lin Chen , Lin Lian-Yu , Lo Men-Tzung , Chien Kuo-Liong 
Published: April 2022

Quantitative EEG (qEEG) delineates complex brain activities. Global field synchronization (GFS) is one multichannel EEG analysis that measures global functional connectivity through quantification of synchronization between signals. We hypothesized that preservation of global functional connectivity of brain activity might be a surrogate marker for good outcome in sudden cardiac arrest (SCA) survivors. In addition, we examined the relation of phase coherence and GFS in a mathematical approach. We retrospectively collected EEG data of SCA survivors in one academic medical center. We included 75 comatose patients who were resuscitated following in-hospital or out-of-hospital nontraumatic cardiac arrest between 2013 and 2017 in the intensive care unit (ICU) of National Taiwan University Hospital (NTUH). Twelve patients (16%) were defined as good outcome (GO) (CPC 1–2). The mean age in the GO group was low (51.6 ± 15.7 vs. 68.1 ± 12.9, p &lt; 0.001). We analyzed standard EEG power, computed EEG GFS, and assessed the cerebral performance category (CPC) score 3 months after discharge. The alpha band showed the highest discrimination ability (area under curve [AUC] = 0.78) to predict GO using power. The alpha band of GFS showed the highest AUC value (0.8) to predict GO in GFS. Furthermore, by combining EEG power + GFS, the alpha band showed the best prediction value (AUC 0.86) in predicting GO. The sensitivity of EEG power + GFS was 73%, specificity was 93%, PPV was 0.67%, and NPV was 0.94%. In conclusion, by combining GFS and EEG power analysis, the neurological outcome of the nontraumatic cardiac arrest survivor can be well-predicted. Furthermore, we proved from a mathematical point of view that although both amplitude and phase contribute to obtaining GFS, the interference in phase variation drastically changes the possibility of generating a good GFS score.
Insulin for topical use in wound healing: opportunities and limitations
Authors: Benkő Beáta-Mária , Sebe István , Szabó Zoltán-István 
Published: April 2022

Aims: The role of insulin in the regulation of energy metabolism, protein synthesis, proliferation, migration, secretion by keratinocytes, endothelial cells, and fibroblasts suggests that its presence is essential for wound healing (WH). The present study aims to explore the opportunities and limitations of topical insulin (TI) formulations. Methods: To obtain a complete picture of the challenges of the local insulin formulation a chronological review of previous publications in electronic databases was performed, applying data collection and selection criteria. Results: The opportunity of topically applied insulin has shown active interest over time. According to studies, regular insulin and isophane are suitable for local use, but currently there is no consensus on the appropriate concentration. Insulin can be incorporated into cutaneous liquid, semisolid, and solid dosage forms, either by itself, or by prior nano-or microencapsulation methods. The most important limiting factors to be evaluated are the stability of the peptide and the sterility of the obtained products. Conclusion: Examination of the balance of opportunities and limitations of TI formulations, it can be concluded that the range of applicable technological methods is wide. A high-quality, safe, and efficacious form of TI would have great value from a socio-economic point of view.
PELATIHAN PENGELOLAAN USAHA DENGAN TEKNIK PEMASARAN MARKETPLACE DI DESA JAMBUGEULIS KECAMATAN CIGANDAMEKAR KABUPATEN KUNINGAN
Authors: Sugiharto Tito , Herwanto Heri , Krisdiawan Rio Andriyat , Kurniadi Erik 
Published: April 2022

Jambugeulis Village is one of the villages in Kuningan Regency whose people generally have a livelihood as farmers and day laborers. Apart from being farmers and daily laborers, the people of Jambugeulis village also have jobs as traders and home-made food makers. There are several types of home-cooked food produced by the people of Jambugeulis village, including moring (a type of small cracker made from tapioca flour), cassava tape food, and cuhcur cake. The people of Jambugeulis village in the process of marketing traditional food products still use conventional methods, namely by selling products directly to consumers and in collaboration with traditional food gift shops. The conventional sales process has several shortcomings/weaknesses including the marketing process of traditional food products is still limited only in Kuningan Regency, the profit of the Jambugeulis village community is slightly reduced from the normal selling price due to a reduction in distribution costs. The difficulty of access for consumers from outside the Kuningan Regency to buy/obtain traditional food products from Jambugeulis village. With this fact, the author feels compelled to carry out business management training with marketplace techniques by utilizing the latest developments in information technology. The methods implemented in this community service activity are the Lecture method, the Question and Answer method, and the Simulation method. From the results of the activities that have been carried out, participants are very enthusiastic about participating in the activities and understand the importance of business management by utilizing marketpalce.
Key words: Training, business management, marketplace, Jambugeulis village
PELATIHAN MENDELEY DAN TEKNIK ANALISIS DATA DENGAN EVIEWS
Authors: Nurisman Husain , Sampurna Dian Surya , Nuryati Tutty , Santoso Joko Bagio , Aminoto Toto , Purwo Bagus Styoko 
Published: April 2022

Pengabdian Kepada Masyarakat (PKM) is one of the three dharmas of university education, or the major responsibility of lecturers. This PKM activity is open to students completing their last year at private universities. PKM activities include the evaluation of "Mendeley Training and Data Analysis Techniques." PKM activities will take place online via the media zoom on July 31, 2021, from 8:00 a.m. to 12:00 a.m. WIB. The implementation team for this activity is led by a lecturer from STIE Indonesia in Rawamangun, East Jakarta, and comprises lecturers from the State University of Jakarta (UNJ). This activity is intended for students completing their last year at private universities who match the following criteria: There were 111 participants representing 24 universities from DKI Jakarta, West Java, Surabaya, Semarang, Yogyakarta, Padang, Bangka Belitung, Jember, and Samarinda. This community service activity (PKM) produces the following outputs: (1) Improving students' understanding of the thesis preparation process; (2) Improving students' understanding of the structure and proper citation of reference sources; and (3) Improving students' capacity to interpret research findings.
Key words: pengabdian kepada masyarakat, microsoft word, mendeley, eviews
Pelatihan Deteksi Dini Attention Deficit Hyperactivity Disorder (ADHD) pada Guru KB-TK Labschool Unesa
Authors: Satwika Yohana Wuri , Satiningsih  , Siti Ina Savira  , Miftakhul Jannah  , Ira Darmawanti  
Published: April 2022

ADHD (Attention Deficit Hyperactivity Disorder) is a medical disorder that can be recognized by specific behavioral characteristics, namely inattention to surroundings, easily distracted condition, and an attitude of following one's own will. Children diagnosed with ADHD require special treatment so that their specificity can be fulfilled. Teacher knowledge about ADHD is an important thing in order to detect and provide the right educational model for students. The implementation of this training in community service uses modules and early detection tools for ADHD children or students. The purpose of this activity is so that teachers can identify the condition of their students whether any of these students lead to the characteristics of ADHD. Based on the results of the post-test and case discussions, the teachers at the beginning of the activity stated that they were still confused about the condition of their students so that they understood the situation of their students more clearly. The teachers also stated that they more clearly see the condition of the students they work with in class, especially for students who have a tendency to ADHD.

ADHD (Atention Deficit Hiperactivity Disorder) adalah kelainan medis yang dapat dikenali dengan ciri-ciri perilaku khusus sikap kurang memperhatikan sekeliling, kondisi mudah terganggu, dan sikap mengikuti kemauannya sendiri. Anak yang terdeteksi ADHD membutuhkan penanganan yang khusus agar kekhususannya dapat terpenuhi. Pengetahuan guru tentang ADHD menjadi sebuah hal yang penting dalam rangka mendeteksi dan memberikan model pendidikan yang tepat bagi siswa. Pelaksanaan pelatihan dalam pengabdian kepada masyarakat ini ini menggunakan modul dan alat deteksi dini untuk anak/ siswa ADHD. Tujuan kegiatan ini adalah agar para guru dapat mengenali kondisi siswa mereka apakah ada dari para siswa tersebut yang mengarah kepada ciri-ciri ADHD. Berdasarkan hasil pre test post test dan diskusi kasus, para guru yang diawal kegiatan menyatakan masih bingung mengenai kondisi siswa mereka menjadi lebih memahami keadaan siswa mereka secara lebih jelas. Para guru juga menyatakan mereka lebih jelas melihat kondisi siswa yang mereka tangani di kelas terutama untuk siswa yang memiliki kecenderungan ADHD.
Implementasi Analytic Network Process untuk Penentuan Tempat Pembuangan Akhir
Authors: Windarto Yudi Eko , Windasari Ike Pertiwi , Winarto Oki 
Published: April 2022

Perkembangan gaya hidup memiliki dampak negatif yaitu semakin banyak limbah yang dihasilkan setiap hari, tak terkecuali kondisi di Kabupaten Pemalang oleh karena itu diperlukan juga pengolahan limbah sampah yang baik dan efisien di Tempat Pembuangan Akhir. Proses pemilihan lokasi Tempat Pembuangan Akhir itu merupakan salah satu aspek penting dan banyak hal yang harus diperhatikan. Untuk mendapatkan keputusan yang objektif dan akurat kini diperlukan pengolahan data komputerisasi dengan metode modern menggunakan sistem pendukung keputusan. Metode yang digunakan di dalam sistem ini ialah Analytic Network Process atau disingkat menjadi ANP. Metode ini akan diimplementasikan pada pengolahan data untuk menentukan Tempat Pembuangan Akhir yang terbaik di suatu daerah dan akan ditampilkan secara visual menggunakan peta carto. Sistem ini akan memberikan hasil peringkat dan gambaran daerah yang terbaik untuk dibangun sebuah Tempat Pembuangan Akhir pada suatu daerah. Sistem ini dibangun menggunakan bahasa pemrograman PHP dan database SQL.
Desafios, práticas e saberes sobre as cidades médias: um olhar a partir de Mato Grosso do Sul
Authors: Martinelli Silva Calixto Maria José , Alves Teles Glauciana 
Published: April 2022

O que nasceu como uma tentativa de aproximar pesquisadores de diversas áreas, de mobilizar os membros do Conselho Editorial da SertãoCult na elaboração de um material que exprimisse a capacidade da editora em produzir obras com qualidade técnica e com relevância acadêmica, tornou-se um sucesso logo em sua primeira edição. Após o lançamento do volume Diálogos sobre a Ditadura, que reuniu alguns dos maiores pesquisadores sobre a temática no Brasil, a série Território Científico chega ao seu segundo volume elaborado a partir de uma parceria com os profissionais ligados ao Seminário da Rede de Pesquisadores sobre as Cidades Médias (ReCiMe). Eis a obra “Trajetórias de pesquisadores e os estudos das cidades médias em perspectiva”. É gratificante concluirmos mais esta contribuição para a comunidade científica, apresentando as trajetórias de algumas das maiores referências da Geografia Urbana brasileira, que no contexto da pandemia da Covid-19 ficaram tão fisicamente distantes, mas nunca tão próximos, unidos através da tecnologia, que permitiu a troca de experiências com colegas de diferentes regiões do país. Passados alguns meses da realização das entrevistas, finalmente a pandemia dá mostras de arrefecimento. O isolamento que tanto nos custou, começa a dar lugar a reencontros presenciais e estas entrevistas, mais do que um relato de experiências de pesquisa, passam a compor um registro histórico de como a crise sanitária afetou toda a nossa sociedade. Se a produção científica segue sendo alvo de constantes ataques e aqueles que se dedicam a ela ainda são encarados quase como inimigos do Estado, é mais do que pertinente, mas necessário que todos aqueles que acreditam na educação, na ciência, no conhecimento se unam e abracem projetos que busquem aproximar essa produção e o público em geral. Mais um livro se junta à nossa série, nos deixando ainda mais orgulhosos e empenhados em nossa defesa incondicional da ciência. Que venham os próximos volumes!
Modelo de impresión 3D para planificación quirúrgica en trasplante hepático con donante vivo adulto-adulto
Authors: Gamez del Mauro Brenda Andrea , Montoya Moya Carlos , Puelma Calvo Luís Felipe , Buckel Gonzalez Erwin Gunter , Buckel Schaffner Erwin , Jarufe Nicolás 
Published: April 2022

Gracias a los grandes avances de la tecnología, los últimos diez años, la impresión en tres dimensiones (3D) se ha convertido en una herramienta accesible, útil e innovadora para distintas áreas de la medicina. Entre ellas; planificación quirúrgica, creación de implantes y prótesis, educación médica e incluso comunicación médico-paciente.Con respecto a planificación quirúrgica, la impresión 3D cobra especial relevancia en cirugías de alta complejidad. En el caso del trasplante hepático con donante vivo, donde es prioritario garantizar la máxima seguridad para el donante, al mismo tiempo que la mejor calidad del injerto para el receptor, la planificación quirúrgica es mandatoria. En este aspecto, la impresión 3D de un modelo de hígado, anatómicamente comparable al del donante, entrega al cirujano la posibilidad de obtener una imagen más clara, directa y tangible, desde cualquier ángulo del órgano, que una imagen virtual tradicional. De esta forma, el cirujano tiene a su alcance una herramienta adicional para plantear el mejor abordaje quirúrgico, anticipar variaciones anatómicas e incluso, cuando el material de impresión lo permite, practicar el procedimiento.En Clínica Las Condes, el centro de trasplante junto al Centro de Innovación, trabajaron en conjunto en la impresión 3D de dos modelos de hígado, utilizados para la planificación quirúrgica de los primeros dos trasplantes hepáticos con donante vivo adulto-adulto realizados en Latinoamérica, donde la hepatectomia del donante se realizó de manera totalmente laparoscópica. El objetivo de este trabajo es describir el proceso de impresión 3D y analizar las dificultades y beneficios del proceso y sus resultados. Palabras clave: Impresión 3D, planificación quirúrgica, donante vivo, trasplante de hígado.
Kinerja reproduksi sapi betina Peranakan Ongole sebagai akseptor inseminasi buatan di Kecamatan Ratahan Kabupaten Minahasa Tenggara
Authors: Ratulangi M.A. , Ngangi L.R. , Poli Z. 
Published: April 2022

Tujuan penelitian ini untuk mengetahui kinerja reproduksi sapi betina peranakan ongole sebagai akseptor inseminasi buatan di Kecamatan Ratahan Kabupaten Minahasa Tenggara. Metode penelitian yang dilakukan dalam penelitian ini adalah metode survey dengan menggunakan kuesioner sebagai alat pengumpul data. Dari hasil wawancara dengan peternak didapatkan 30 ekor sapi betina yang menjadi akseptor inseminasi buatan dan telah mengalami lebih dari 2 kali beranak. Variabel yang diukur yaitu umur awal sapi dijadikan akseptor, tanda-tanda estrus yang terdeksi, Service per Conception, Calving Interval. Data dari setiap variabel dihitung secara deskriptif melalui ukuran pemusatan dan standar deviasi dan ditampilkan dalam bentuk tabel. Hasil penelitian di peroleh bahwa kinerja reproduksi sapi betina peranankan ongole sebagai akseptor inseminasi buatan di kecamatan ratahan kabupaten minahasa tenggara adalah dengan service per conception 1,5 ± 0,73; calving interval 442 ± 13,49. Kesimpulannya adalah kinerja reproduksi sapi betina Peranakan Ongole sebagai akseptor inseminasi buatan di Kecamatan Ratahan sudah tergolong baik.Kata kunci: Akseptor Inseminasi Buatan, Kinerja reproduksi, Sapi Peranakan Ongole