bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized Product Design Through Digital Fabrication
Authors: Minnoye A. (Sander) L. M. , Tajdari Farzam , Doubrovski E. (Zjenja) L. , Wu Jun , Kwa Felix , Elkhuizen Willemijn S. , Huysmans Toon , Song Yu (Wolf) 
Published: November 2022

Abstract
Personalized designs bring added value to the products and the users. Meanwhile, they also pose challenges to the product design process as each product differs. In this paper, with the focus on personalized fit, we present an overview as well as details of the personalized design process based on design practice. The general workflow of personalized product design is introduced first. Then different steps in the workflow such as human data/parameters acquisition, computational design, design for digital fabrication, and product evaluation are presented. Tools and methods that are often used in different steps in the process are also outlined where in human data acquisition, 3D scanning, and digital human models are addressed. For computational design, the use of computational thinking tools such as abstraction, decomposition, pattern recognition and algorithms are discussed. In design for digital fabrication, additive manufacturing methods (e.g. FDM), and their requirements on the design are highlighted. For product evaluation, both functional evaluation and usability evaluation are considered and the evaluation results can be the starting point of the next design iteration. Finally, several case studies are presented for a better understanding of the workflow, the importance of different steps in the workflow and the deviations in the approach regarding different contexts. In conclusion, we intend to provide designers a holistic view of the design process in designing personalized products as well as help practitioners trigger innovations regarding each step of the process.
Design for Multi-Material Manufacturing Using Polyjet Printing Process: A Review
Authors: Chadha Charul , Olaivar Gabriel , Patterson Albert E. , Jasiuk Iwona M. 
Published: November 2022

Abstract
Additive manufacturing (AM) of thermosetting polymer materials has been a topic of interest since the early days of technology development but has not gotten the attention of the common thermoplastic processes. AM’s general capability to produce intricate geometries along with a wide range of material properties has made it one of the primary manufacturing options for multi-material manufacturing, a major niche for thermosetting resins and similar materials. These multi-material structures are formed by strategically placing materials with different mechanical properties to enhance material performance significantly. As a result, interest in multi-material additive manufacturing (MM-AM) has increased dramatically in the last decade. While on the one hand, MM-AM has introduced new opportunities for design engineers, on the other hand, it has also increased the design considerations required to manufacture the part successfully. This paper reviews the major literature on the topic from the perspective of product and material system design, focusing on the material jetting approach, most commonly known as the PolyJet process. Specific topics include design advancements, materials, and challenges while printing MM-AM components with PolyJet. Findings on four broad topics are discussed, including the effect of interface on material properties, testing standards, established material and material combinations, and design guidelines for MM-AM. Additional design criteria needed for MM-AM are summarized for design engineers to help create reliable components with predictable mechanical behavior.
Preliminary Modeling of Angle of Attack in Self-Rectifying Turbine Under High Rotational Speed
Authors: Wu Xian , Zuo Lei 
Published: November 2022

Abstract
Wave energy has the potential to contribute significant parts to the future energy system. Various Wave Energy Converters (WECs) have been proposed, modeled, and tested to harvest wave energy. However, to date, none of the proposed works have been used commercially. Here, we present a modelling of a cyclorotor type WEC with adjustable pitch angle. The angle of attack is optimized within the controllable range to match the total resultant force to the tangential direction. Instead of following a frequency matching between the cyclorotor and the wave, results show that higher rotational speed of the cyclorotor can significantly increase the output power.
In Situ FTIR Spectroscopic Imaging of Asphaltene Deposition from Crude Oil under n-Heptane and Acetone Flows
Authors: Shalygin A. S. , Milovanov E. S. , Kovalev E. P. , Yakushkin S. S. , Kazarian S. G. , Martyanov O. N. 
Published: November 2022

Abstract
Asphaltene deposition from crude oil, induced by n-heptane and acetone flows in a microfluidic device, was studied by optical and FTIR spectroscopic imaging techniques in situ. It was found that n-heptane and acetone penetrate crude oil in completely different ways, which is responsible for the formation of deposits with different structures and chemical compositions. The contact of the n-heptane flow with crude oil leads to fast aggregation of asphaltenes at the interface, resulting in the formation of a compact deposit fixed to the surface. Subsequent slow diffusion of n-heptane into crude oil causes asphaltene aggregation and precipitation of loose deposits. In the case of acetone, the flocculant diffuses (faster than n-heptane) into crude oil, which results in removal of its soluble components and in the formation of deposits appearing as strips as well. The distribution of the functional groups (–OH(NH), CH2–CH3, C=O, C–O, S=O) in the deposits is spatially heterogeneous. The asphaltenes deposits formed at the flocculant-crude oil interface are richer in the functional groups than those formed during diffusion. No carbonyl groups were revealed in the deposits formed in the acetone flow, while oxygen-containing groups such as –OH(NH) and S=O were present, which was an unusual result.
Mental health among the sugarcane industry farmers and non-farmers in Peru: a cross-sectional study on occupational health
Authors: Bazo-Alvarez Juan Carlos , Bazalar-Palacios Janina , Bazalar Jahaira , Flores Elaine C 
Published: November 2022

ObjectiveDescribe the occupational characteristics of farmer and non-farmer workers and investigate critical occupational risk factors for mental disorders in sugarcane farmers in Peru.MethodWe conducted a cross-sectional study with occupational health and safety focus among farmers and non-farmers. Mental disorder symptoms were evaluated through the local validated version of the 12-Item General Health Questionnaire (GHQ-12). We explored the association between mental disorder symptoms, work conditions and known occupational risk factors (weekly working hours, pesticide exposures, heat stress and heavy workload). Negative binomial regression models were fitted, and 95% CIs were calculated.ResultsWe assessed 281 workers between December 2019 and February 2020. One hundred and six (37.7%) respondents identified themselves as farmworkers. The mean GHQ-12 scores for farmers and non-farmers were 3.1 and 1.3, respectively. In the fully adjusted multivariable model, mental disorder symptom counts among farmers were more than twice as high as those of non-farmers (β: 2.11; 95% CI: 1.48 to 3.01). The heavy workload increased the mean number of mental disorder symptoms by 68% (95% CI: 21% to 133%), and each additional working hour per day increased the mean number of mental disorder symptoms by 13% (95% CI: 1% to 25%).ConclusionFarmers have higher mental disorder symptoms than non-farmers. A heavy workload and more working hours per day are independently associated with more mental disorder symptoms. Our findings highlight the importance of including mental health within occupational programmes and early interventions tailored to sugarcane industrial mill workers in the Latin American context.
Optimisation of treatments for oralNeisseria gonorrhoeaeinfection: Pharmacokinetics Study (STI-PK project) – study protocol for non-randomised clinical trial
Authors: Kong Fabian Y S , Unemo Magnus , Lim Shueh H , Latch Ngaire , Williamson Deborah A , Roberts Jason A , Wallis Steven C , Parker Suzanne L , Landersdorfer Cornelia B , Yap Tami , Fairley Christopher K , Chow Eric P F , Lewis David A , Hammoud Mohamed A , Hocking Jane S 
Published: November 2022

IntroductionNeisseria gonorrhoeaeinfections are common and incidence increasing. Oropharyngeal infections are associated with greater treatment failure compared with other sites and drive transmission to anogenital sites through saliva. Gonococcal resistance is increasing and new treatments are scarce, therefore, clinicians must optimise currently available and emerging treatments in order to have efficacious therapeutic options. This requires pharmacokinetic data from the oral cavity/oropharynx, however, availability of such information is currently limited.Methods and analysisHealthy male volunteers (participants) recruited into the study will receive single doses of either ceftriaxone 1 g, cefixime 400 mg or ceftriaxone 500 mg plus 2 g azithromycin. Participants will provide samples at 6-8 time points (treatment regimen dependent) from four oral sites, two oral fluids, one anorectal swab and blood. Participants will complete online questionnaires about their medical history, sexual practices and any side effects experienced up to days 5–7. Saliva/oral mucosal pH and oral microbiome analysis will be undertaken. Bioanalysis will be conducted by liquid chromatography-mass spectrometry. Drug concentrations over time will be used to develop mathematical models for optimisation of drug dosing regimens and to estimate pharmacodynamic targets of efficacy.Ethics and disseminationThis study was approved by Royal Melbourne Hospital Human Research Ethics Committee (60370/MH-2021). The study results will be submitted for publication in peer-reviewed journals and reported at conferences. Summary results will be sent to participants requesting them. All data relevant to the study will be included in the article or uploaded as supplementary information.Trial registration numberACTRN12621000339853.
Aetiology of extracranial carotid free-floating thrombus in a prospective multicentre cohort
Authors: Dowlatshahi Dar , Lum Cheemun , Menon Bijoy K , Bharatha Aditya , Dave Prasham , Puac-Polanco Paulo , Blacquiere Dylan , Stotts Grant , Shamy Michel , Momoli Franco , Thornhill Rebecca , Lun Ronda , Torres Carlos 
Published: November 2022

BackgroundCarotid free-floating thrombi (FFT) in patients with acute transient ischaemic attack (TIA)/stroke have a high risk of early recurrent stroke. Management depends on aetiology, which can include local plaque rupture, dissection, coagulopathy, malignancy and cardioembolism. Our objectives were to classify the underlying aetiology of FFT and to estimate the proportion of patients with underlying stenosis requiring revascularisation.MethodsWe prospectively enrolled consecutive patients presenting to three comprehensive stroke centres with acute TIA/stroke and ipsilateral internal carotid artery FFT. The aetiology of FFT was classified as: carotid atherosclerotic disease, carotid dissection, cardioembolism, both carotid atherosclerosis and cardioembolism, or embolic stroke of uncertain source (ESUS). Patients with carotid atherosclerosis were further subclassified as having ≥50% or <50% stenosis.ResultsWe enrolled 83 patients with confirmed FFT. Aetiological assessments revealed 66/83 (79.5%) had carotid atherosclerotic plaque, 4/83 (4.8%) had a carotid dissection, 10/83 (12%) had both atrial fibrillation and carotid atherosclerotic plaque and 3/83 (3.6%) were classified as ESUS. Of the 76 patients with atherosclerotic plaque (including those with atrial fibrillation), 40 (52.6%) had ≥50% ipsilateral stenosis.ConclusionsThe majority of symptomatic carotid artery FFT are likely caused by local plaque rupture, more than half of which are associated with moderate to severe carotid stenosis requiring revascularisation. However, a significant number of FFTs are caused by non-atherosclerotic mechanisms warranting additional investigations.
Analytical study of the first collision time finiteness between two randomly moving particles in a fractured medium
Authors: Alzulaibani Alaa Awad , El-Hadidy Mohamed Abd Allah 
Published: November 2022

This paper presents the stronger moment conditions which are sufficient to show the finiteness of the first collision time between [Formula: see text]-dimensional Gaussian jump particle and another [Formula: see text]-dimensional Brownian particle in a fractured medium. To obtain these conditions, we use the triangular arrays of the random sequence vector which gives all probable positions of the first collision at any time. This study is an extension of the analytical study which is detailed in Alzulaibani and El-Hadidy [Int. J. Mod. Phys. B 33(28) (2019) 1950334] using the uniform integrability conditions.
On wreath products of groups, semigroups and algebras
Authors: Alahmadi Adel , Alsulami Hamed , Jain S. K. , Zelmanov Efim 
Published: November 2022

We review various constructions of wreath products of groups, semigroups, Lie algebras and associative algebras and discuss their realizations in matrix wreath products of associative algebras. As an application we prove a new version of Evans’s embedding theorem [T. Evans, Embedding theorems for multiplicative systems and projective geometries, Proc. American Math. Soc. 3 (1952) 614–620].
Radiofrequency Ablation Remodels the Tumor Microenvironment and Promotes Neutrophil-Mediated Abscopal Immunomodulation in Pancreatic Cancer
Authors: Faraoni Erika Y. , O'Brien Baylee J. , Strickland Lincoln N. , Osborn Baron K. , Mota Victoria , Chaney Jarod , Atkins Constance Lynn , Cen Putao , Rowe Julie , Cardenas Jessica , Poulsen Kyle L. , Wray Curtis J. , Thosani Nirav C. , Bailey-Lundberg Jennifer M. 
Published: November 2022

Abstract

Pancreatic ductal adenocarcinoma (PDAC) presents a 5-year overall survival rate of 11%, despite efforts to improve clinical outcomes in the past two decades. Therapeutic resistance is a hallmark of this disease, due to its dense and suppressive tumor microenvironment (TME). Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a promising local ablative and potential immunomodulatory therapy for PDAC. In this study, we performed RFA in a preclinical tumor-bearing KrasG12D; Trp53R172H/+; Pdx1:Cre (KPC) syngeneic model, analyzed local and abscopal affects after RFA and compared our findings with resected PDAC specimens. We found that RFA reduced PDAC tumor progression in vivo and promoted strong TME remodeling. In addition, we discovered tumor-infiltrating neutrophils determined abscopal effects. Using imaging mass cytometry, we showed that RFA elevated dendritic cell numbers in RFA-treated tumors and promoted a significant CD4+ and CD8+ T-cell abscopal response. In addition, RFA elevated levels of programmed death-ligand 1 (PD-L1) and checkpoint blockade inhibition targeting PD-L1 sustained tumor growth reduction in the context of RFA. This study indicates RFA treatment, which has been shown to increase tumor antigen shedding, promotes antitumor immunity. This is critical in PDAC where recent clinical immunotherapy trials have not resulted in substantial changes in overall survival.
Reperfusion Injury Is Associated With Poor Outcome in Patients With Recanalization After Thrombectomy
Authors: Zhou Ying , He Yaode , Yan Shenqiang , Chen Lin , Zhang Ruoxia , Xu Jinjin , Hu Haitao , Liebeskind David S. , Lou Min 
Published: November 2022

Background:
The existence of cerebral reperfusion injury in human beings remains controversial. Thus, we aimed to explore the presence of reperfusion injury in acute ischemic stroke patients with recanalization after mechanical thrombectomy and analyzed its impact on neurological outcome.

Methods:

We reviewed our prospectively collected database CIPPIS (Comparison Influence to Prognosis of CTP and MRP in AIS Patients, NCT03367286), and enrolled anterior circulation large artery occlusion patients with recanalization after mechanical thrombectomy who underwent (1) computed tomography (CT) perfusion on admission and immediately after recanalization to determine reperfusion region, and (2) CT and/or magnetic resonance imaging (MRI) immediately and 24 hours after recanalization to determine lesion areas. The expansion of lesion between recanalization and 24 hours within reperfusion region was potentially caused by reperfusion, thus termed as radiological observed reperfusion injury (RORI). Based on the imaging modality immediately after recanalization, RORI was further divided into RORI
CT
and RORI
MRI
. We first included a small cohort who had performed both CT and MRI immediately after recanalization to validate the consistency between RORI
CT
and RORI
MRI
(Study 1). Then the association with RORI
CT
and poor outcome, defined as 3-month modified Rankin Scale score of 3 to 6, was explored in a larger cohort (Study 2).

Results:

Study 1 included 23 patients and good consistency was found between RORI
CT
and RORI
MRI
(intraclass correlation=0.97,
P
<0.001). Among 226 patients included in Study 2, a total of 106 (46.9%) were identified with RORI. The ratio of RORI to reperfusion region was 30.1 (16.2, 51.0)% and was independently associated with poor outcome (odds ratio=1.55 per 10% [95% CI‚ 1.30–1.84];
P
<0.001).

Conclusions:
Our findings suggested that RORI was relatively frequent in stroke patients with recanalization after mechanical thrombectomy and associated with poor outcome despite successful recanalization.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03367286.
Rescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis
Authors: Almallouhi Eyad , Murad Mohammad Hassan , Chalhoub Reda , Kicielinski Kimberly P. , Lena Jonathan , Brennan Emily A. , Zaidat Osama , de Havenon Adam , Spiotta Alejandro M. , Al Kasab Sami 
Published: November 2022

Background
Patients with acute stroke presenting with large vessel occlusion secondary to intracranial atherosclerosis (ICAS‐LVO) may require rescue therapy (RT) in addition to mechanical thrombectomy to achieve and maintain successful recanalization. We performed a systematic review and meta‐analysis of comparative studies that reported outcomes of RT in patients with ICAS‐LVO to evaluate its safety and efficacy.

Methods
Databases searched include PubMed, CINAHL Complete, and Scopus from database date of inception through August 17, 2021. We included comparative studies that reported the outcomes of ICAS‐LVO RT compared with outcomes of patients with ICAS‐LVO who did not undergo RT or to those patients presenting with embolic large vessel occlusion (non–ICAS‐LVO). Meta‐analysis using the random‐effects model was used to combine estimates reporting odds ratios (ORs) and 95% CIs.

Results

A total of 9 nonrandomized studies were included: 5 studies in ICAS‐LVO RT versus ICAS‐LVO non‐RT analysis and 5 in ICAS‐LVO RT versus non‐ICAS LVO analysis. Rescue treatments included intra‐arterial antiplatelets, angioplasty, stenting, or a combination of treatments. Compared with non‐RT ICAS‐LVO, RT was associated with an increased favorable 90‐day outcome (OR, 3.19 [95% CI, 1.91–5.32];
I
2
= 14%) and decreased 90‐day mortality (OR, 0.35 [95% CI, 0.16–0.76];
I
2
= 21%). In the analysis of ICAS‐LVO RT versus embolic LV, the incidence of favorable 90‐day outcome and 90‐day mortality did not differ between ICAS‐LVO RT and non–ICAS‐LVO (OR, 0.97 [95% CI, 0.58–1.64;
I
2
= 50%]; and OR, 1.22 [95% CI, 0.90–1.66;
I
2
= 0%], respectively).

Conclusions
Rescue treatment is likely associated with better outcomes in patients with ICAS‐LVO. The outcomes of patients with ICAS‐LVO who receive RT may be comparable with patients with embolic large vessel occlusion (non–ICAS‐LVO).
Clinging to a Jewish Saint in a Time of Growing Turmoil: Appropriating the Figure of Rabbi Judah the Pious in Late Fifteenth-Century Jewish Folktales from Regensburg
Authors: Shoham-Steiner Ephraim (Effie) 
Published: November 2022

Abstract
Among a unique collection of stories in Hebrew manuscript copied in the sixteenth century and found at the National Library of Israel (NLI) are twenty-seven hagiographic tales about the prominent Jewish pietist of Medieval Germany, Rabbi Judah the Pious (d. 1217) and his father Rabbi Shmuel ben Kalonymus. Scholars have suggested that the entire original collection dates back to ca. 1300 and echoes the lives, concerns, and ideals of thirteenth-century Ashkenazi Jews. However, some of the hagiographic tales found in the collection seem to have been written later, appropriating the figure of the mystical Rabbi Judah and using it in stories from the fifteenth century that were set in his city, Regensburg. Told by the Jews of this city, the tales of Rabbi Judah and his magical abilities seem to have fulfilled the needs and concerns of the community in the turbulent late fifteenth century. The paper analyzes three of these stories, demonstrating how they correspond with the realities of this time and suggesting the possible roles the tales of Rabbi Judah and his miracles played for Regensburg Jewry as they contended with the hardships of daily life and the shadow of expulsion that loomed large over the community in this period.
Waging Peace, towards an Africa Union Stabilisation Strategy for Somalia
Authors: Tchie Andrew E. Yaw 
Published: November 2022

Abstract
Over the last few years, successful military operations across Somalia have helped to unshackle towns south of Mogadishu from al Shabaab, demonstrating the capacity of the African Union Mission to Somalia (amisom) to achieve parts of its mandate. However, friction between the Federal Government of Somalia and the Federal Member States have heightened tensions and rifts over elections, state management and overall security, despite significant international support. Despite amisom s efforts, the legacies of the 1990s civil war have remained unresolved, and state restoration has been disrupted by political, clannish, environmental and structural challenges. In contrast, al Shabaab remains adaptable, resilient and exploits grievances, local dynamics, and competition over resources. This paper argues, the African Union (AU) Peace and Security Council needs to re-mandate and reinforce amisom in conjunction with an AU stabilisation strategy for Somalia which exploits experiences from the AU’s Regional Stabilisation Strategy for the Lake Chad Basin.
The Masyumi Networks and the Proliferation of Islamic Higher Education in Indonesia (1945–1965)
Authors: Latief Hilman 
Published: November 2022

Abstract
This article addresses the roles played by Masyumi political leaders in fuelling dakwah activism in Indonesia and energizing the inception and proliferation of Islamic higher education institutions before and after the political turmoil faced by the Masyumi party. Islamic politics and education in Indonesia were intermingled and utilized by Masyumi leaders to promote Islam, foster the dignity of the ummah (Muslim community), and achieve Maysumi’s political vision via non-political activism. Using social-structure networks analysis, this article argues that the Masyumi networks and the spirit of Islamic modernism accelerated the spread of Islamic higher education in Indonesia, especially from 1945–1965. The Masyumi networks consisted of Muslim politicians, the intelligentsia, technocrats, noble families, and businesspeople.