bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of pesticide residues in vegetables from Mekong, Delta, Vietnam using LC-MS/MS
Authors: Nguyen Ngoc-Van Thi , Nguyen Kim-Ngan Huynh , Duong Tuyet-Ngan , Tran Van De , Kim Kyeong Ho , Pham Lien To Thi 
Published: March 2022

Purpose: To assess the levels of pesticide residues in commonly used vegetables in Vietnam as a reference for future monitoring.
Methods: A total of 180 samples of six different fresh vegetables including watercress, mustard green, choy sum, daikon, okra, and yam were analyzed from Mekong Delta, Vietnam. Ten popular pesticides were evaluated using liquid chromatography-tandem mass spectrometry (LC-MS/MS) after extraction with a multi-residue method (QuEChERS method).
Results: The results were assessed according to the maximum residue limit (MRL) provided by Codex for each pesticide in each commodity. Pesticide residues above the MRL were detected in 107 samples (59 %) and 63 samples (47 %) contained residues below the MRL. Multiple residues were present in 38.3% of the samples with two to five pesticides, and 0.6 % of samples were contaminated with more than five pesticide residues. Of the pesticides investigated, eight pesticides were detected, of which abamectin, alpha-cypermethrin, acetamiprid, chlorpyrifos- ethyl, chlorantraniliprole, fenobucarb, fipronil, and trichlorfon exceeded their MRLs. Pesticide residues were detected above MRLs in samples of watercress (14 samples), mustard green (24 samples), choy sum (25 samples), daikon (26 samples), and yam (18 samples). Chlorpyrifos-ethyl, and fipronil were detected in most of the vegetable samples (100% and 89.44%, respectively).
Conclusion: The results indicate the occurrence of pesticide residues in commonly consumed vegetables in Vietnam. The need for the regular monitoring of pesticide residues and the sensitization of farmers to better pesticide safety practices, especially the need to adhere to recommended pre-harvest intervals is recommended.
Effect of a combination of infrared irradiation and magnesium sulfate wet compress on infection and healing of episiotomy incision in puerperae
Authors: Li Shangfang , Gao Hua , Zhang Zhonggang , Mi Zhenhui 
Published: March 2022

Purpose: To investigate the effect of a combination of infrared irradiation and magnesium sulfate wet compress on infection and healing of episiotomy incision in puerperae during spontaneous delivery.
Methods: A total of 120 puerperae who underwent lateral episiotomy in Jinan Maternity and Child Hospital Affiliated to Shandong First Medical University from January 2019 to January 2020 were used as study subjects. They were randomly assigned to group A (n = 60) and group B (n = 60). Group B received external application of anerdian, while group A was treated with infrared irradiation and magnesium sulfate wet compress, in addition to receiving the treatment given to group B. The two groups were compared with respect to perineal edema, levels of inflammatory factors, wound pain grading, degree of incision healing, incision healing time, and incidence of infection.
Results: Group A patients had significantly lighter perineal edema and more pronounced pain relief than group B patients (p < 0.05). The number of puerperae with grade A healing and grade C healing in group A was significantly higher than that in group B (p < 0.05). Incision healing time and incidence of infection were lower in group A than in group B (p < 0.05).
Conclusion: The combination of infrared irradiation and magnesium sulfate wet compress effectively mitigates perineal edema in puerperae, reduces pain, enhances the healing of incision, and lowers maternal infection. Thus, this combination strategy may have some merit in clinical practice.
Comparison of effectiveness of continuous subcutaneous insulin infusion with daily insulin injection in a Chinese population of Type I diabetic patients
Authors: Yi Qianqian , Wu Zhiyu , Dong Junhua , Zhang Ningning , Li Qiuyue , Gao Na 
Published: March 2022

Purpose: To compare the clinical effectiveness of continuous subcutaneous insulin infusion therapy with that of multiple-dose insulin therapy in type 1 diabetic patients.
Methods: A total of 1000 type 1 diabetic patients were assigned to two groups, with 500 patients per group. Patients in group I were treated with continuous subcutaneous infusion of insulin (CSII), while those in group II received multiple daily doses of insulin injection. Body mass index (BMI), insulin dose, HbA1c levels, and frequencies of hypoglycemia and diabetic-ketoacidosis (DKA) were determined in each patient at baseline, and at 4-week intervals for 4 years.
Results: The HbA1c levels at baseline and at the end of 4th year in group I were 8.9 ± 1.1 and 8.2 ± 1.5 %, respectively, relative to corresponding values of 8.6 ± 1.2 and 9.1 ± 1.1 %, respectively in group II. The results revealed significant difference in HbA1c between the two groups (p < 0.05). After 4 years of therapy, insulin requirement was markedly higher in group II than at baseline (0.8 ± 0.1 vs 0.9 ± 0.2, p < 0.05) IU/kg/day. However, insulin requirement in group I decreased after 4 years, relative to that at baseline (0.65 ± 0.2 vs 0.8 ± 0.1 IU/kg/day; p < 0.05).
Conclusion: CSII therapy seems to be an effective and safe gold standard method for managing type I diabetes mellitus patients.
MicroRNA-612 regulates the proliferation and epithelial-to-mesenchymal transition of human colon cancer cells via G protein-coupled receptor 132 (GPR132)
Authors: Shen Sha , Guo Qingqing , Zhan Shuiping 
Published: March 2022

Purpose: To investigate the effect of microRNA-612 (miR-612) on human colon cancer cells, and the mechanism involved.
Methods: Expressions of miR-612 and GPR132 were determined by quantitative real-time polymerase chain reaction (qRT-PCR)el , while cell viability was evaluated using cell counting kit-8 (CCK8) and colony formation assays. Dual luciferase assay was used to determine the interaction between miR-612 and GPR132, while cell migration and invasion were measured by Transwell assay.
Results: The expression levels of miR-612 in colon cancer tissues and cell lines were significantly down-regulated (p < 0.05). Overexpression of miR-612 in colon cancer cells led to significant inhibition of their proliferation and colony formation. Transwell assays revealed that miR-612 overexpression markedly stopped the migration, invasion and epithelial-to-mesenchymal transition.
Conclusion: These results indicate that miR-612 exerts anti-cancer effect by suppressing the expression of GPR132 at the translational level. The in vitro tumor suppressive activity of miR-612 against colon cancer reveals its potential for the management of colon cancer.
Blocking NLRP3 inflammasome expression by RAS-like protein A mitigates neuropathic pain in chronic constriction injury rat models
Authors: Qiu Jin , Xie Mian 
Published: March 2022

Purpose: To investigate the role of RAS-like protein A (RalA) in lipopolysaccharide-induced inflammatory regulation in primary microglia of chronic constriction injury (CCI)-induced neuropathic pain in rat models.
Methods: In vitro, overexpression (OE) of RalA was performed in rat microglia using transfection procedure, and then LPS was used to provoke the inflammatory phenotype. In vivo, the rat model of neuropathic pain was induced using CCI and treated with LV-RalA. Neuroinflammatory levels including the expressions of IL-1β, IL-6, and TNF-α were detected. Moreover, the expressions of NF-κB p65, thioredoxin-interacting protein (TXNIP) and NLR family pyrin domain-containing 3(NLRP3)were examined in CCI rats and microglial cells. Finally, the functional evaluation was determined via mechanical allodynia and thermal hyperalgesia assays.
Results: The level of RalA decreased in the dorsal horn following CCI. OE of RalA in microglia after LPS insult and CCI-induced rat model significantly decreased the expressions of inflammation promoters (p < 0.05). Mechanistically, OE of RalA mitigated inflammatory response by inhibiting NF-κB/TXNIP/NLRP3 signaling pathway, thus attenuating neuropathic pain in microglial cells and CCI rats.
Conclusion: These results indicate that the OE of RalA plays a protective role in CCI-induced neuropathic pain via NF-κB/TXNIP/ NLRP3 axis. These findings may provide a promising therapeutic target for neuropathic pain.
Effect of Dachaihu decoction on traditional Chinese medicine-related indices of Type 2 diabetes in rats, and elucidation of its mechanism of action
Authors: Zhang Qiuju , Wang Zhufeng , Xu Hongliang , Qin Li , An Ran , Zhang Ying 
Published: March 2022

Purpose: To study the influence of Dachaihu decoction on traditional Chinese medicine (TCM)-related indices of type 2 diabetes mellitus (T2DM) in rats, and the likely mechanism involved.
Methods: Forty-five healthy male SD rats were randomly selected and used to establish T2DM rat model. The rats were randomly assigned to 3 groups: control, model and Dachaihu decoction groups (n = 15). Fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), free fatty acids (FFAs), total cholesterol (TC) and oxidative stress were measured. Pathological changes in rats in each group were monitored, and mRNA levels of PDX-1 and MaFA in pancreatic tissue were measured.
Results: The levels of FBG, HbAlc, FFA, TC, MDA and ROS in the Dachaihu decoction group were significantly decreased, while SOD, PDX-1 mRNA and MafA mRNA were markedly raised, relative to control (p < 0.05). In the Dachaihu decoction group, the rats had pink paws; their noses and tongues were glossy and moist, and there was more physical activity, relative to model rats (p < 0.05).
Conclusion: These results indicate that Dachaihu decoction is effective against T2DM in rats. The mechanisms of action may be by inhibition of oxidative stress, improvement of the function of islet beta cells, and mitigation of symptoms of fatigue and dehydration. Therefore, Dachaihu decoction may be useful for adjuvant treatment of TCM-T2DM but clinical studies are required to ascertain this.
Phytochemical characterization and anti-cancer properties of extract of Ephedra foeminea (Ephedraceae) aerial parts
Authors: Al-saraireh Yousef M. , Youssef Ahmed M.M. , Alshammari Fatemah O.F.O. , Al-Sarayreh Sameeh A. , Al-Shuneigat Jehad M. , Alrawashdeh Hamzeh M. , Mahgoub Samir S. 
Published: March 2022

Purpose: To evaluate the phytochemical profile of methanol extract of Ephedra foeminea and assess its anti-carcer effect on a large set of normal and cancerous cell lines.
Methods: Extraction of air-dried powder of aerial parts of E. foeminea was carried out with methanol. The bioactive compounds in the extract were determined using gas chromatography/mass spectrometry (GC-MS). The anti-cancer effect of the extract was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay against various types of normal and cancer cell lines. Serial concentrations of plant extract were used, ranging from 7.812 to1000 μg/mL. Doxorubicin (DOX) served as standard drug. The half-maximal concentration (IC50) values of the extract and DOX for each cell line were determined, and the selectivity index (SI) was computed.
Results: Phytochemical analysis showed that the extract contained several bioactive compounds, including alkaloids, flavonoids, sterols and fatty acids. The hazardous ephedra alkaloids (ephedrine and pseudoephedrine) were absent in the plant extract. The extract showed significant anti-proliferative activity against cancer cell lines, when compared with the positive control, doxorubicin (p < 0.05). Selective and concentration-dependent cytotoxicity was exhibited in cancer cell lines of breast (MCF-7), lung (A549), colon (Caco-2), liver (HepG-2) and prostate (PC-3). Weak selectivity was produced in other cancer cell lines, i.e., human epithelioma (Hep-2) and cervical carcinoma (Hela). Interestingly, non-cancerous cells showed no or weak cytotoxicity.
Conclusion: Ephedra foeminea exerts potential selectivity in anti-proliferative effect against some cancer cell lines. Thus, it is a promising drug source for the production of new and selective anti-cancer medicines.
Xuebijing injection alleviates liver injury in patients with hepatocellular carcinoma by inhibiting inflammatory response after transarterial chemoembolization
Authors: Zhong Chen , Cheng Feng 
Published: March 2022

Purpose: To study the influence of Xuebijing (XBJ) injection on patients with hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE), and to elucidate the underlying mechanism of action.
Methods: Thirty-nine HCC patients were retrospectively analyzed. They were assigned to 3 groups: negative group which received no XBJ injection, low-dose XBJ group given XBJ injection (50 ml), and high-dose XBJ group given 100 mL of XBJ injection. Peripheral blood was separately collected andanalyzed on the first day after admission and TACE.
Results: TACE led to liver damage in HCC patients, with increased serum activities of ALT and AST, and total bilirubin (tBLB). Moreover, TACE elevated white blood cells, neutrophil count, C-reactive protein (CRP) and expression levels of inflammation cytokines. In the groups treated with XBJ injection,there were dose-dependent mitigation of liver dysfunction, and reduced levels of inflammatory cytokines, when compared with the negative group. However, XBJ injection did not affect myelosuppression or regulatory T cells.
Conclusion: XBJ dose-dependently decreases liver injury in HCC patients after TACE by suppressing inflammatory response. Thus, XBJ may exert hepatoprotective effect on HCC after TACE in humans in clinical practice.
Effect of apatinib combined with chemotherapy on quality of life and related complications in patients with advanced gastric cancer
Authors: Hong Dan , Wei Yaning , Zang Aimin , Wang Zhiyu , Yang Lin , Ren Guanying , Su Shenyong , Zhang Chong 
Published: March 2022

Purpose: To investigate the effect of apatinib combined with chemotherapy on quality of life (QOL) and related complications in patients with advanced gastric cancer (AGC).
Methods: Clinical data for 102 AGC patients treated in The Affiliated Hospital of Hebei University (January 2018 - December 2019) were retrospectively analyzed. The subjects were randomly and equally split into chemotherapy group and combination group. Both groups of patients were treated with 180 mg/m2 of paclitacel, and patients in the combination group were additionally given 500 mg of apatinib daily, for a treatment time to disease remission in both groups. Clinical efficacy, QOL, complications as well as serum SIL-2R, VEGF and TNF-α levels in the two groups were compared to analyze the effect of apatinib combined with chemotherapy on AGC patients.
Results: Disease control rate (DCR) and overall response rate (ORR) of gastric cancer patients in the combination group were notably higher than those in the chemotherapy group (p < 0.05). After treatment, the serum SIL-2R, VEGF and TNF-α levels in the two groups decreased significantly, of which the levels in the combination group were clearly lower (p < 0.05). No notable difference in the incidence of complications was observed between the two groups (p > 0.05). After treatment, the QOL scores of both groups increased significantly, of which QOL score in the combination group was notably higher (p < 0.05).
Conclusion: Apatinib combined with chemotherapy effectively enhances the clinical efficacy of AGC patients, controls the overexpression of serum SIL-2R, VEGF and TNF-α, and improves the QOL of patients without increasing adverse reactions. Therefore, the combination therapy is safe and effective.
Treatment of vulval condyloma with a combination of paiteling and cryotherapy, and its effect on late recurrence
Authors: Wang Lijun , Tian Hongshuai , Liu Guiqing , Yu Yan , Li Haili , Chen Leilei , Xiong Hongwei 
Published: March 2022

Purpose: To study the clinical effectiveness of a combination of Paiteling and cryotherapy in the treatment of vulval condyloma acuminatum (VCA), and its effect on late recurrence.
Methods: Eighty-six VCA patients were chosen as research subjects, and were randomized into group A and group B. Group A patients were treated with combination of Paiteling and cryotherapy, while group B patients received cryotherapy only. The clinical effects of the two treatment methods on VCA were evaluated by measuring area of damaged skin, levels of interleukin-6 (IL-6) and C-reactive protein (CRP), as well as degree of recurrence of VCA in the two groups, before and after treatment.
Results: Total clinical treatment effectiveness in group A was significantly higher compared with group B (p < 0.05). After treatment, the area of damaged skin, and levels of IL-6 and CRP were markedly lower in group A than in group B (p < 0.001). After 6 months of treatment, disease control was higher in group A than in group B (p < 0.05). There was also a lower incidence of adverse reactions in group A than in group B (p < 0.05).
Conclusion: These results indicate that the combination of Paiteling and cryotherapy is more effective than cryotherapy alone in improving treatment effectiveness and reducing late recurrence of VCA. Therefore, the combined treatment has potentials clinical application in the management of VCA.
Os estilos de pensamento, a disposição optimista e o autoconceito no jovem portador de deficiência mental ligeira
Authors: Martins Ana Lucia Ferreira Antunes 
Published: March 2022

Na presente investigação pretendemos estudar os estilos de pensamento e a disposição optimista e autoconceito na Deficiência Mental Ligeira. Desenhámos um estudo do tipo correlacional-preditivo com uma amostra constituída por jovens e adultos com Deficiência Mental Ligeira de ambos os géneros, institucionalizados na APPACDM de Viseu e a frequentar os vários cursos de carácter profissional da valência Formação Profissional. Para caracterização e avaliação da amostra nas variáveis investigadas recorremos ao questionário sócio-demográfico, à Escala de Inteligência de Wechsler para adultos (WAIS-III – com uso protocolado na instituição), às Matrizes Progressivas de Raven, nomeadamente as matrizes coloridas e as da escala geral, à Escala de Optimismo de Barros de Oliveira (1998) e ao Inventário Clínico de Autoconceito de Vaz-Serra (1986). Os resultados apontam para a existência de uma correlação positiva significativa entre os estilos de pensamento e a disposição optimista e o autoconceito de cada indivíduo portador de Deficiência Mental Ligeira, sendo a correlação com esta última moderada. Deste modo, no presente estudo podemos verificar que os deficientes mentais ligeiros da amostra estudada apresentam uma forma de pensar e reagir à realidade mediada pela sua disposição optimista e autoconceito (face ao seu grau de deficiência e ao mundo que os rodeia), no sentido de que a presença favorável de uma levar a esperar-se à presença favorável da(s) outra(s). De referir que esta amostra revela no geral indivíduos com boa disposição optimista e bom autoconceito.
Pengelolaan Dana Zakat Produktif untuk Pemberdayaan Masyarakat pada LAZ El-Zawa
Authors: Firmansyah M. Salman , Yuliana Indah 
Published: March 2022

The purpose of this study was to find out how to manage zakat funds effectively in LAZ EL-ZAWA to increase community capacity. The method used by the researcher uses qualitative research and descriptive methods to describe the data obtained from the field, then draws conclusions from the research conducted. In this study, there are two sources of data used, namely, primary data and secondary data where primary data is generated through direct interviews with parties related to research (researchers) and secondary data is obtained from reading sources and various other sources. The result is that at LAZ EL-ZAWA there are two mechanisms used by el-zawa in collecting zakat funds, the first is a personal approach and an institutional approach. There are two objects for distributing productive zakat in el-zawa, the first at the community level by providing capital assistance to MSMEs The second need is to allocate productive zakat funds to students of UIN Maulana Malik Ibrahim by providing scholarships
Estudos de Caso Aplicados a Cursos de Capacitação: Projeto Piloto
Authors: PFEFFER Renato Somberg 
Published: March 2022

O foco do texto são os cursos oferecidos pela Fundação João Pinheiro de Minas Gerais (FJP), por meio da Gerência de Capacitação e Treinamento da Escola de Governo (GCT/EG). Esses cursos Têm a finalidade de aperfeiçoar e atualizar servidores municipais, estaduais e federais e cidadãos interessados nos temas da administração e da gestão pública. No intuito de desenvolver a produção e disseminação de conhecimentos que reafirma a missão, visão e valores institucionais da FJP, o trabalho é um estudo teórico relativo à estratégia de metodologia ativa estudos de caso e sua aplicação em um curso piloto desenvolvido pela GCT da FJP junto à Prefeitura de Contagem/MG em 2020.Estudos de caso. Curso de capacitação. Projeto piloto.ABSTRACT The focus of the text is the courses offered by the João Pinheiro Foundation of Minas Gerais (FJP) through the Management Building and Capacity Department of the School of Government (GCT / EG). These courses have the purpose of improving and updating municipal, state and federal civil servants and citizens interested in the themes of administration and public management. In order to develop the production and dissemination of knowledge that reaffirms the mission, vision and institutional values of FJP, the work is a theoretical study related to the active methodology strategy, case studies and its application in a pilot course developed by the GCT of FJP together to the Municipality of Contagem / MG in 2020.Case studies. Capacitation course. Pilot project.RESUMENEl tema central del texto son los cursos ofrecidos por la Fundación João Pinheiro, de Minas Gerais (FJP) a través del Departamento de Capacitación y Entrenamiento de la Escuela de Gobierno (GCT/EG). Estos cursos tienen como finalidad la mejora y actualización de los funcionarios públicos y ciudadanos interesados en las materias de administración y gestión pública. Con el fin de desarrollar la producción y difusión de conocimientos que reafirmen la misión, visión y valores institucionales de la FJP, el trabajo es un estudio teórico relacionado con la estrategia de metodología activa, estudios de caso y su aplicación en un curso piloto desarrollado por la GCT de la FJP junto a la Municipalidad de Contagem/MG en 2020.Estudios de caso. Curso de capacitación. Proyecto piloto.
Solidaridad y esperanza ante las víctimas de la pobreza injusta
Authors: Sobrino Jon 
Published: March 2022

El autor insiste en una tesis fundamental de l. Ellacuría: la necesidad de revertir la historia actual. Esto significa que no sólo hay que cambiar, mejorar y reformar, sino que, además, hay que revertir, es decir, alterar radicalmente la historia. Aunque no se ofrecen contenidos, se quiere hacer caer en la cuenta de la necesidad de espíritu para generar la fuerza para buscar la solución correcta. Esa fuerza del espíritu es la solidaridad y la esperanza es la actitud radical para emprender la tarea que la humanidad tiene por delante.
ECA Estudios Centroamericanos, Vol. 50, No.557, 1995: 203-213.