bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Security Plastic with Integrated Holographic and Phosphorescent Images
Authors: Yao Ming , Wei Wei , Qiao Weiguo , Zhang Yue , Zhou Xingping , Li Zhong'an , Peng Haiyan , Xie Xiaolin 
Published: February 2025

AbstractOrganic room temperature phosphorescence (ORTP) polymer materials have sparked considerable research interests in recent years, but their optical function is still limited for multi‐mode optical imaging. Herein, a feasible and universal approach is proposed to endow ORTP polymer materials with periodic refractive index modulation functions by holographic patterning. The key to this approach is to design a two‐stage stepwise crosslinking. Stage‐1, with low crosslinking density (≤0.75 mol L−1), is phosphorescence‐silent but can provide greater free volume for monomer diffusion and thus facilitate the patterning of refractive index modulated holograms via photopolymerization‐induced phase separation. The dense crosslinking at stage‐2 can turn on phosphorescence with the intensity rising by 144% when the crosslinking density increases from 3.77 to 4.12 mol L−1. The enhanced phosphorescence is primarily ascribed to the increase of conformational distortion and spin‐orbit coupling of organic phosphors based on theoretical calculations. Eventually, the first example is demonstrated of holographic plastic with the unique capability of independently displaying holographic andphosphorescent images. This work not only provides a novel paradigm to impart added optical functions to ORTP polymer materials but also paves the way for the development of high‐security optical materials to combat counterfeiting.
Antibody‐level Bacteria Grabbing by “Mechanic Invasion” of Bioinspired Hedgehog Artificial Mesoporous Nanostructure for Hierarchical Dynamic Identification and Light‐Response Sterilization
Authors: Liu Sijie , Shu Rui , Jia Huilin , Wang Kexin , Wang Biao , Zhang Jiayi , Sun Jing , Sattorov Nosirjon , Makhmudov Kamoljon Burkhonovich , Jin Maojun , Wang Jianlong 
Published: February 2025

AbstractThe interactions exploration between microorganisms and nanostructures are pivotal steps toward advanced applications, but the antibody‐level bacteria grabbing is limited by the poor understanding of interface identification mechanisms in small‐sized systems. Herein, the de novo design of a bioinspired hedgehog artificial mesoporous nanostructure (core–shell mesoporous Au@Pt (mAPt)) are proposed to investigate the association between the topography design and efficient bacteria grabbing. These observations indicate that virus‐like spiky topography compensates for the obstacles faced by small‐sized materials for bacteria grabbing, including the lack of requisite microscopic cavities and sufficient contact area. Molecular dynamics simulation reveals that spiky topography with heightened mechano‐invasiveness (6.56 × 103 KJ mol−1) facilitates antibody‐level bacteria grabbing, attributed to the “mechanic invasion”‐induced hierarchical dynamic identification ranging from rough surface contact to penetration fixation. Furthermore, light reflectance and finite element calculation confirmed that mAPt exhibits near‐superblack characteristic and plasmonic hot spot, facilitating enhanced photothermal conversion with power dissipation density at 2.04 × 1021 W m−3. After integrating the hierarchical dynamic identification with enhanced light response, mAPt enables advanced applications in immunoassay with 50‐fold sensitivity enhancement and over 99.99% in vitro photothermal sterilization. It is anticipated that this novel biomimetic design provides a deeper understanding of bacteria grabbing and a promising paradigm for bacteria combating.
Non‐Membrane Active Peptide Resensitizes MRSA to β‐Lactam Antibiotics and Inhibits S. aureus Virulence
Authors: Shi Jingru , Chen Chen , Kong Pan , Yu Feiyu , Lv Qingyan , Wang Zhiqiang , Liu Yuan 
Published: February 2025

AbstractMethicillin‐resistant Staphylococcus aureus (MRSA) is a serious global health threat due to its high morbidity and mortality rates, creating a dire need for novel therapeutic strategies. Antimicrobial peptides (AMPs), with broad‐spectrum activity and low propensity for resistance development, show promise as effective antibiotic adjuvants to reverse multidrug‐resistance in bacteria. Herein, it is uncovered that a potent and non‐toxic AMP termed GN1 substantially resensitizes MRSA to multiple β‐lactam antibiotics at low concentrations. Mechanistic studies indicate that GN1 functions by suppressing both the production and enzymatic activity of MRSA‐associated resistance determinants, including penicillin‐binding protein 2a (PBP2a) and β‐lactamase. Additionally, GN1 exhibits a robust anti‐virulence profile by inhibiting MRSA biofilm formation and staphyloxanthin production. Furthermore, GN1 induces bacterial metabolic perturbation, resulting in glutamate accumulation and oxidative damage. Importantly, the combination of GN1 with β‐lactam antibiotics effectively mitigates MRSA‐induced infections in the animal infection models. Collectively, these findings suggest that GN1 represents a potent β‐lactam adjuvant and anti‐virulence agent, offering a safe and versatile solution to combat MRSA infections.
High Strength, Strain, and Resilience of Gold Nanoparticle Reinforced Eutectogels for Multifunctional Sensors
Authors: Huang Yingxiang , Yang Yanzhao , Peng Cong , Li Yu , Feng Wei 
Published: February 2025

AbstractEutectogels with inherent ionic conductivity, mechanical flexibility, environment resistance, and cost‐effectiveness have garnered considerable attention for the development of wearable devices. However, existing eutectogels rarely achieve a balance between strength, strain, and resilience, which are critical indicators of reliability in flexible electronics. Herein, poly(sodium styrenesulfonate) (PSS)‐modified gold nanoparticles (AuNPs) in eutectic solvents are synthesized, and PSS‐AuNP reinforced polyacrylic acid/polyvinylpyrrolidone (SAu‐PAA/PVP) eutectogel is successfully prepared. Through the coordination between AuNPs and the PAA/PVP polymer chains, the SAu‐PAA/PVP eutectogel exhibits significantly enhanced tensile strain (946%), mechanical strength (3.50 MPa), and resilience (85.3%). The high‐performance eutectogel was demonstrated as a flexible sensor sensitive to strain and temperature, and the AuNPs provided near‐infrared sensing capabilities. Furthermore, SAu‐PAA/PVP eutectogel inherits the benefits of ES, including anti‐drying and anti‐freezing properties (−77 °C). Moreover, the eutectogel is microstructured using a simple molding method, and the resulting hierarchical pyramid microstructured eutectogel functions as ionic dielectric layer in a pressure sensor. This sensor exhibits high sensitivity (37.11 kPa−1), low detection limit (1 Pa), a fast response rate (36/54 ms), and excellent reproducibility over 5000 cycles, making them reliable and durable for detecting small vibrations, with potential applications in precision machinery, aerospace, and buildings.
Educating teachers toward immigrant empowerment and liberation in the United States and Chile: A funds of knowledge perspective
Authors: Iddings Ana Christina da Silva , Lamas Macarena , Rojas Carola Lourdes Aravena , Vasquez Katherine Malhue 
Published: February 2025

AbstractThis article examines how university‐based teacher education programs in diverse historical, sociocultural, and political settings in the U.S. and in Chile, served to foster immigrant empowerment and liberation. Using a Funds of Knowledge approach, the study analyzed the educational practices of migrant families and their integration into early childhood teacher education curricula in both countries. Ethnographic methods, including teacher interviews, household visits, and case studies, revealed that engaging with immigrant families fostered critical thinking among teachers, deepened their respect for the families' values and aspirations, and highlighted the rich educational resources within immigrant households. The study underscores the importance of recognizing and incorporating these practices to support young immigrant children's development. However, it also stresses the urgent need to address systemic oppression and entrenched colonial‐racial ideologies that persist in educational systems in both contexts.
Validating a Mixed Qualitative Behavioral Assessment for Adult Western Lowland Gorillas (Gorilla gorilla gorilla) I: Baseline Monitoring
Authors: Gartland Kylen N. , Bovee Emily , Fuller Grace 
Published: February 2025

ABSTRACTTraditional qualitative behavioral assessments (QBAs) employ a unique whole‐animal approach to measure animal welfare with a focus on affective elements. QBAs require comprehensive validation including reliability across multiple raters, subjects, and institutions, as well as consistency with other validated assessment measures. In 2016, the Detroit Zoological Society developed and began internally validating the Gorilla Behavioral Assessment Tool (GBAT), followed by internal applications of a revised GBAT in 2021. This study continues these validation efforts through the multi‐institutional application of the GBAT in baseline conditions. Five zoological institutions participated in this study, creating a study population of 15 adult male western lowland gorillas (Gorilla gorilla gorilla) and more than 40 staff. Care staff collected fecal samples from each gorilla, and two staff from each institution completed the GBAT for each gorilla daily. Three of the five institutions collected focal behavioral data. We calculated inter‐rater reliability using Gwet's AC2, establishing near‐perfect reliability across all tested items. We found no significant variation in reliability between institutions. We used the behavioral data and fecal glucocorticoid metabolites for construct validation. A combination of Spearman's correlations and generalized linear mixed models demonstrated statistically significant relationships between seven of the 12 tested GBAT items and other established measures. Integration of physical and behavioral indicators of welfare alongside affective indicators alters the GBAT from a traditional QBA into what we propose as a mixed or M‐QBA. Our work demonstrates how an M‐QBA allows for a more comprehensive assessment of animal welfare with implications for broader research applications.
Towards Surface‐Enhanced Homogeneous Catalysis: Tailoring the Enrichment of Metal Complexes at Ionic Liquid Surfaces
Authors: Hemmeter Daniel , Haumann Marco , Williams Federico J. , Koller Thomas M. , Wasserscheid Peter , Meyer Karsten , Maier Florian , Steinrück Hans‐Peter 
Published: February 2025

AbstractWhen talking about homogeneous catalyst systems, it has long been assumed that the system at hand consists of a transition metal complex in solution with the liquid interface representing the composition of the bulk solution. Now, in light of considerable developments in the study of metal complexes dissolved in ionic liquids with their negligible vapor pressures, more detailed studies of the composition at the liquid/gas interface became possible. These investigations revealed pronounced surface enrichment and segregation effects of high relevance for practical applications. This article reviews recent advancements in tailoring the interfacial composition of ionic liquid‐based catalytic systems. A particular focus is dedicated to surface enrichment phenomena, and a variety of parameters are presented for deliberate control of the local concentration of the complexes at the surface, that is, the nature of the ligands, the bulk concentration, the temperature, and the nature of the IL solvent. As experimental methods, angle‐resolved X‐ray photoelectron spectroscopy (ARXPS) and vacuum‐based pendant‐drop surface tension measurements were applied. The reviewed results are intended to provide the basis for the advancement of catalytic systems with high surface areas, such as in supported ionic liquid phase (SILP) catalysis, where the interface design is directly interconnected with catalytic performance.
Foot arch height, arch stiffness, and intrinsic muscle size are not strongly associated with daily physical activity levels in a cross‐sectional study of adults in the United States
Authors: Lauer Chloé , Holowka Nicholas B. , Worthington Steven , Kraft Thomas S. , Wallace Ian J. 
Published: February 2025

AbstractThe feet of people in non‐industrial societies often have higher, stiffer longitudinal arches (LAs) and larger intrinsic muscles than those of many people in post‐industrial societies. The prevailing explanation for this phenomenon is that people in post‐industrial societies commonly wear shoes that restrict foot mobility, while people in non‐industrial societies are often habitually barefoot or minimally shod. However, people in post‐industrial societies also tend to be less physically active than in non‐industrial societies, and it is possible that this, too, is a major determinant of their foot form and function. Here, we test the hypothesis that among people in post‐industrial societies, lower physical activity levels are associated with lower, less stiff LAs and smaller intrinsic muscles. In a cross‐sectional analysis of 40 adults in the United States, none of whom were habitually barefoot or minimally shod, we measured daily physical activity using accelerometry, LA height and static stiffness using photography, LA dynamic stiffness using kinematic and kinetic data, and intrinsic muscle size using ultrasound. Using Bayesian models, we found very low probabilities of positive associations between physical activity (step count, time spent in moderate‐to‐vigorous activity) and LA height, LA static stiffness, and muscle size. For LA dynamic stiffness, we found small to moderate probabilities of positive associations with physical activity variables. These findings suggest that physical activity is unlikely a major determinant of variation in LA and intrinsic muscle form and function among post‐industrial societies. It remains possible that physical activity affects LA and intrinsic muscle traits, but perhaps primarily among people who are habitually barefoot or minimally shod.
Prenatal Opioid Use Disorder and the Risk of Congenital Anomalies in Offspring: A Population‐Based Study
Authors: Ramage Kaylee , Yee Jennifer , Srugo Sebastian , Little Julian , Liu Shiliang 
Published: February 2025

ABSTRACTObjectiveTo examine whether prenatal opioid use disorder (OUD) diagnosis is associated with the risk of congenital anomalies (CAs) in offspring.MethodsWe conducted a population‐based study of mother–newborn dyads comprising.4143 761 births delivered in Canada from 2006 to 2021. We used robust Poisson regression to examine the association between prenatal OUD diagnosis and risk of non‐chromosomal CAs, adjusted for maternal age, parity, multiple gestation, co‐morbidities (including mental health disorders, chronic illnesses and other substance use disorders), and infant sex.ResultsWe identified a total of 21, 638 births to persons who were diagnosed with prenatal OUD and 65, 992 (159.3 per 10,000) newborns with CAs. The overall risk of CAs was 2.3 times higher in infants born to birthing persons with a diagnosis of OUD (95% CI 2.2, 2.5). Compared to those without OUD diagnoses, births to persons with a diagnosis of OUD had a higher risk of specific types of congenital microcephaly (aRR 5.2, 95% CI 4.1, 6.6), cleft palate (RR 4.8, 95% CI 3.7, 6.1), pulmonary valve atresia with intact ventricular septum (aRR 2.7, 95% CI 1.1, 6.7), and atrial septal defect (aRR 3.1, 95% CI 2.8, 3.5), among others. In particular, infants born to those with an OUD diagnosis had a 1.8 (95% CI 1.4, 2.3)‐fold increased risk of having severe congenital heart disease.ConclusionOur findings suggest an association between prenatal OUD diagnosis and certain CAs in the offspring. Future research is necessary to better understand the role of socio‐demographic factors on these associations.
Evaluation of Nanocurcumin Effects on Depressive‐Like Behaviors in Rats and Determination of Serum BDNF and Serotonin Levels
Authors: Jahromi Mahsa Hadipour , Charousaei Hasti , Charousaei Ali 
Published: February 2025

ABSTRACTIntroductionMajor depressive disorder (MDD) is a highly prevalent psychiatric condition worldwide, and it is the leading cause of disability globally. Turmeric, an aromatic perennial herb widely used in traditional Asian medicine and cuisine, contains curcumin, which has several biological effects, including a pseudoantidepressant effect. However, curcumin's low bioavailability limits its effectiveness. This study evaluated nanocurcumin (NCUR) effects on depressive‐like behaviors and examined serum BDNF and serotonin levels in a chronic stress model in rats. Behavioral assessments and biochemical indicators elucidated NCUR's antidepressant‐like properties.MethodsIn this experimental study, 30 adult male rats were randomly divided into six groups and exposed to unexpected chronic mild stress (UCMS). The groups included: control (CG), stress control (SCG), fluoxetine (FLU) treatment (20 mg/kg), and three NCUR doses (20, 40, and 80 mg/kg). Before UCMS exposure, rats underwent a sucrose preference test (SPT). Depressive behaviors were then assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) on days 27 and 28. Blood samples were collected on day 28 to measure serum Brain derived neurotrophic factor (BDNF) and serotonin levels using enzyme‐linked immunosorbent assay (ELISA).ResultsNCUR treatment significantly alleviated depressive‐like behaviors in stressed rats. The sucrose preference index of the SCG decreased after 26 days of stress, while NCUR (all doses) and FLU reversed this effect. In the FST and TST, immobility time was significantly reduced in the NCUR and FLU groups compared to the SCG (p < 0.05). The OFT also showed that the SCG had significantly fewer crossings compared to treated groups (p < 0.05). Additionally, NCUR treatment significantly increased serum BDNF and serotonin levels compared to the SCG.ConclusionsThis study demonstrates that NCUR exerts antidepressant‐like effects, improving depressive behaviors and increasing BDNF and serotonin levels in rats exposed to chronic stress. NCUR may offer a promising alternative for the treatment of MDD.
Alternations of Plasma Fatty Acids in Patients With Bipolar Depression Under Acute Treatment of rTMS Combined With Quetiapine and Mood Stabilizer
Authors: Yu Huan , Liang Xue‐jun , Qiao Yu‐ting , Guo Lin , Li Zhao‐yang , Zhou Cui‐hong , Wu Wen‐jun , Li Rui , Peng Zheng‐wu 
Published: February 2025

ABSTRACTPurposeRepetitive transcranial magnetic stimulation (rTMS) represents a potential clinical tool in treating bipolar disorder (BD). However, the intervention of rTMS combined with pharmacotherapy on the plasma fatty acids (FAs) in patients with bipolar depression has not been reported yet.MethodIn this study, we assessed the clinical symptoms and evaluated plasma FAs from 30 inpatients with bipolar depression at baseline phase (BD group), after 2 weeks of treatment with rTMS combined with quetiapine and mood stabilizer (BD‐2w group), and 32 healthy controls (HCs).FindingWe found that acetic acid, propionic acid, isovaleric acid, isobutyric acid, and valeric acid, as well as levels of total short‐chain fatty acids (SCFAs), were decreased in both BD and BD‐2w groups, and levels of several medium‐ and long‐chain fatty acids (MLCFAs) were altered in BD when compared with HC. Moreover, 2 weeks of treatment increased the levels of various MLCFAs. Finally, we developed combinational FAs panels that could distinguish BD from HC (area under the curve [AUC] = 0.961), BD‐2w from HC (AUC = 0.978), and BD from BD‐2w (AUC = 0.891) effectively.ConclusionThese findings might provide a basis for developing diagnostic methods and reveal the potential relationship between bipolar depression and plasma FAs.
The Role of the VWF/ADAMTS13 Axis in the Thromboinflammatory Response in Ischemic Stroke After SARS‐CoV2 Infection
Authors: Luka Nadim , South Kieron , Jones Rachel , Unsworth Amanda J. , Coutts Graham , Mosneag Ioana‐Emilia , Younas Mehwish , Bradley Amy , Wong Siew Yan , Collins Ellen , Quigley Chloe , Knight Sean B. , McColl Barry W. , McCulloch Laura , Grainger John R. , Smith Craig J. , Allan Stuart M. 
Published: February 2025

ABSTRACTBackgroundSARS‐CoV2 infections increase the risk of ischemic stroke (IS), potentially through a thromboinflammatory cascade driven by an imbalance in the ratio of Von Willebrand Factor (VWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), leading to the formation of ultra‐large VWF (UL‐VWF). However, the SARS‐CoV2 infection's contribution to any VWF/ADAMTS13 axis imbalance and the subsequent thromboinflammatory response post‐stroke remain poorly understood.MethodsWe performed a detailed thromboinflammatory profile of the plasma samples from three experimental cohorts matched by age, sex, and stroke severity: non‐stroke controls (n = 23), SARS‐CoV2 negative IS (n = 22), and SARS‐CoV2 positive IS (n = 24). SARS‐CoV2 positive IS patients presented varying degrees of infection severity.ResultsWe observed an increase in VWF and UL‐VWF and a decrease in ADAMTS13 in the SARS‐CoV2 positive IS cohort, suggesting a VWF/ADAMTS13 axis imbalance. Interleukin‐6 (IL‐6) levels were positively correlated with VWF and negatively correlated with ADAMTS13, suggesting that IL‐6 may drive this imbalance. Fibrinogen and D‐Dimers were elevated in SARS‐CoV2 negative IS cohort and SARS‐CoV2 positive IS cohort, but D‐Dimers were within the normal range, indicating no disseminated intravascular coagulation. Factor IX (FIX) was elevated in the SARS‐CoV2 negative IS cohort. Tissue plasminogen activator (tPA) was elevated in the SARS‐CoV2 positive IS cohort, suggesting no fibrinolysis defects. Matrix Metalloproteinase‐2 (MMP‐2) and soluble Intracellular Adhesion Molecule‐1 (sICAM‐1) were elevated in the SARS‐CoV2 negative IS cohort.ConclusionsWe show that SARS‐CoV2 infections drive a VWF/ADAMTS13 axis imbalance, inducing an increase in tPA while decreasing FIX, MMP‐2, and sICAM‐1 post‐stroke.
Association of the Lipidome With Alzheimer's Disease and the Mediated Effect of Metabolites: A Two‐Step Mendelian Randomization Study
Authors: Yu Yunfeng , Deng Juan , Yang Xinyu , Wu Jingyi , Yu Rong , Guo Chenlu 
Published: February 2025

ABSTRACTObjectiveThis study aimed to explore the causal effects of lipidome on Alzheimer's disease (AD) and the mediated effects of the metabolites using Mendelian randomization (MR).MethodsData were obtained in genome‐wide association studies, and single‐nucleotide polymorphisms were screened according to the underlying assumptions of MR. Subsequently, weighted inverse variance was used to analyze the causality of lipidome with AD as well as the mediated effects of metabolites. Finally, MR‐Egger, Cochran's Q, and sensitivity analysis were used to assess horizontal pleiotropy, heterogeneity, and robustness of the results, respectively.Results:The MR analysis showed that phosphatidylcholine (PC) (15:0_18:2) (mediated proportion: 18.30%, p = 0.024) and phosphatidylethanolamine (PE) (18:0_18:2) (mediated proportion: 14.60%, p = 0.028) mediated the reduction of AD risk by lowering betaine levels, which revealed lipidomic susceptibility. The MR‐Egger intercept showed no horizontal pleiotropy for all results (p ≥ 0.05). Cochran's Q showed heterogeneity in some of the results. Sensitivity analysis indicated that all results were robust.ConclusionOur findings reveal the pathways through which PC (15:0_18:2) and PE (18:0_18:2) mediated the reduction of AD risk by lowering betaine levels.