bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation on scaling failure of heat exchanger in cooling water system of natural gas purification plant
Authors: Jiang Jingjing , Huang Ganghua , Wang Yanran , Fan Rui 
Published: June 2022

AbstractIn this study, a natural gas purification plant adopts open circulating water system, which cannot work properly and hinder the normal production of natural gas due to the problems such as scaling and blockage in the operation of heat exchanger device was reported. Qualities of the make‐up water and recirculating cooling water were evaluated by parameters such as hardness, alkalinity, pH, and conductivity. X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), and optical microscope were employed to study the crystal structure, composition, and morphology of the scale deposits. The flow rate of the water in the tube bundle was calculated according to the design scale of these exchangers. The Langelier Saturation Index (LSI) was used to analyze the scale tendency of the cooling water system. The scale inhibition performance of the inhibitor was verified by static inhibition method. Results show that the scale mainly contains calcium carbonate, and the quality of circulating water is reasonably controlled with a proper range. However, there are three units sharing one cooling water system, of which the flow rate cannot be adjusted according to the actual heat load. The calculation results confirmed that the circulating water velocity in the tube bundle did not exceed 0.9 m/s. Although the scale inhibitor has a scale inhibition efficiency of more than 90% for the simulated circulating water at 80°C, the LSI analysis results showed that the high local temperature on the surface of the tube bundle caused by the low flow rate of water will increase the scaling tendency of the heat exchanger. Furthermore, the untimely injection of the inhibitor in the daily management and operation also greatly increased the risk of system scaling. This paper proves that the scaling of circulating water heat exchanger in the purification plant is mainly caused by device design and poor daily management. In order to prevent future failures, potential solutions and mitigation strategies were put forward.
The hidden dimension to political instability: Insights from ministerial durations in Papua New Guinea from 1972 to 2017
Authors: Ivarature Henry 
Published: June 2022

AbstractThis article introduces a dataset on ministerial tenure in Papua New Guinea (PNG). The dataset, which spans from 1972 to 2017 and covers 15 governments and 321 ministers, is used to study ministerial duration and stability. To do this, two measures of ministerial duration and two stability indicators have been developed. These measures show that ministerial instability is high in PNG but it has not become worse over time. They also show, however, that instability has varied considerably between governments. Drawing on PNGʼs political history, this article provides a discussion of this variation by examining the circumstances of particular governments.
Towards Solid‐State Magnesium Batteries: Ligand‐Assisted Superionic Conductivity
Authors: Skov Lasse N. , Grinderslev Jakob B. , Rosenkranz Asger , Lee Young‐Su , Jensen Torben R. 
Published: June 2022

AbstractSolid‐state inorganic magnesium batteries are considered as potential high energy storage devices of the future. Here we present a series of magnesium borohydride tetrahydrofuran (THF) composites, Mg(BH4)2 ⋅ xTHF(−MgO), 0≤x≤3, as solid‐state electrolytes for magnesium batteries. Three new monoclinic compounds were identified, Mg(BH4)2 ⋅ 2/3THF (Cc), α‐Mg(BH4)2 ⋅ 2THF (P21/c) and β‐Mg(BH4)2 ⋅ 2THF (C2), and the detailed structures of α‐ and β‐Mg(BH4)2 ⋅ 2THF are presented. The magnesium ionic conductivity of composites formed by these compounds were several orders of magnitude higher than that of the distinct compounds, x=0, 2/3, 2, and 3. The nanocomposite stabilized by MgO nanoparticles (∼50 nm), Mg(BH4)2 ⋅ 1.5THF−MgO(75 wt%), displayed the highest Mg2+ conductivity, σ(Mg2+)∼10−4 S cm−1 at 70 °C, a high ionic transport number of tion=0.99, and cyclic voltammetry revealed an oxidative stability of ∼1.2 V vs. Mg/Mg2+. The electrolyte was stable towards magnesium electrodes, which allowed for stable Mg plating/stripping for at least 100 cycles at 55 °C with a current density of 0.1 mA cm−2. Finally, a proof‐of‐concept rechargeable solid‐state magnesium battery was assembled with a magnesium metal anode and a TiS2 cathode. A maximum discharge capacity of 94.2 mAh g−1 was displayed, which corresponds to y=0.2 in MgyTiS2.
How can banks and finance companies incorporate value chain factors in their risk management strategy? The case of agro‐food firms
Authors: Wasan Pratibha , Kumar Ashwani , Luthra Sunil 
Published: June 2022

AbstractA value chain framework for guiding the financial firms in their credit decisions is urgent, as the current COVID‐19 pandemic has highlighted, but missing in the extant literature, particularly for those that lend to industries sensitive to value and supply chain bottlenecks. This study creates knowledge in value chain finance, a big untapped and un‐researched market. It constructs, confirms, and validates a value chain framework for assessing risks in lending to Agro and Food Processing firms in which value chain risks are major business concerns globally. To pursue the objectives of the study, we use a novel methodology that integrates the Modified Delphi technique, exploratory factor analysis, confirmatory factor analysis, and discriminant analysis. Based on testing and analysis of primary data, including loan data, a framework comprising six factors is proposed for use in conjunction with existing risk assessment models of finance companies to improve the quality of their credit decisions, contributing to their performance sustainability.
Metabolic dysfunction and obesity‐related cancer: Results from the cross‐sectional National Health and Nutrition Examination Survey
Authors: Winn Maci , Karra Prasoona , Haaland Benjamin , Doherty Jennifer A. , Summers Scott A. , Litchman Michelle L. , Gunter Marc J. , Playdon Mary C. , Hardikar Sheetal 
Published: June 2022

AbstractBackgroundMetabolic syndrome (MetS), a group of risk factors that define metabolic dysfunction in adults, is strongly associated with obesity and is an emerging risk factor for cancer. However, the association of MetS and degree of metabolic dysfunction with obesity‐related cancer is unknown.MethodsUsing National Health and Nutrition Examination Survey data from 1999 to 2018, we identified 528 obesity‐related cancer cases and 18,972 cancer‐free participants. MetS was defined as the presence of or treatment for ≥3 of hyperglycemia, hypertension, hypertriglyceridemia, low HDL–cholesterol, and abdominal obesity. A metabolic syndrome score (MSS) was computed as the total number of abnormal MetS parameters to determine the severity of metabolic dysfunction. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression models, adjusting for sociodemographic and lifestyle factors.ResultsAbout 45.7% of obesity‐related cancer cases were classified as having MetS compared with only 33.0% of cancer‐free participants. Overall, MetS and MSS were not associated with obesity‐related cancer. However, MSS was associated with higher obesity‐related cancer risk among participants under 50 years of age (OR [95% CI] = 1.28 [1.08–1.52]). When evaluating MSS categorically, compared with healthy participants with no abnormal MetS parameters (MSS = 0), participants with one or two abnormal parameters had a statistically significant higher risk of obesity‐related cancer (OR [95% CI] = 1.73 [1.06–2.83]).ConclusionsMetabolic dysfunction is associated with a higher risk of obesity‐related cancer, particularly in young adults under 50 years of age, and among participants with one or two abnormal metabolic parameters. A more accurate indicator of metabolic dysfunction, beyond metabolic syndrome, is needed to better assist in stratifying individuals for obesity‐related cancer risk.
Receiving teletherapy in Ireland: The experiences of service users in the public mental health system
Authors: Maher Michael , Reilly Katie , Smith Elaine , Coyne Elaine , Murphy Síle , Wilson Charlotte 
Published: June 2022

AbstractObjectiveThe present study explored the experiences of service users of Adult Mental Health and Primary Care services in Ireland in receiving teletherapy during the COVID‐19 pandemic to provide an illustration of these experiences which may inform future applications of teletherapy.MethodSemi‐structured telephone interviews about participants' experiences with teletherapy were conducted, the transcripts of which were analysed using reflexive thematic analysis.ResultsSix themes were generated: Early Apprehensions, Adaptations Improving Experiences, The Therapeutic Space, Seeing and Being Seen, Technical Difficulties: The Loss of “The Moment,” and The Security of a Pre‐Existing Relationship.ConclusionGenerated themes highlight both the range of experiences that clients can have during teletherapy, and some of the most significant factors which influence these experiences. The quality and effectiveness of teletherapy are often susceptible to factors outside of therapists' and clients' control. In most cases, it may be best considered as a supplement to, rather than a replacement for, traditional in‐person services.
Antimicrobial Activity of Volatile Oils from Brazilian Stingless BeesMelipona quadrifasciata quadrifasciataandTetragonisca angustulaPropolis
Authors: Valcanaia Camila Panini , Masote Júlia Beatriz Berkenbrock , Sommer Heloísa Fontana , Schiquet Scarlet , Padilha Bruna , Krepsky Larissa , Paganelli Camila Jeriane , Borges Pâmela Pacassa , Danielli Letícia Jacobi , Apel Miriam Anders , Soares Krissie Daian , Althoff Sérgio , Alberton Michele Debiase , Botelho Tatiani Karini Rensi , Guedes Alessandro , Mendes de Cordova Caio Maurício 
Published: June 2022

AbstractFew studies were performed on the volatile components’ properties of propolis from native Brazilian stingless bees. This work sought to extract, chemically characterize, and evaluate of the antimicrobial properties of volatile oils from propolis of the stingless beesMelipona quadrifasciata quadrifasciata(MQ) andTetragonisca angustula(TA). The volatile oils from the pulverized propolis samples were obtained in a Clevenger apparatus and characterized by gas chromatography coupled to mass spectrometry (GC/MS) and to flame ionization detector (GC‐FID). All samples showed promising activity againstMycoplasma pneumoniae, with MICs from 103 to 224 μg mL−1, nonetheless, they were less active against cell walled bacteria. Activity againstCandidaspecies was moderate, but one MQ sample showed a MIC value of 103 μg mL−1againstC. tropicallis. Oils’ fractionation showed no improvement in antibacterial activity. The promising antibacterial effect against this microorganism is likely related to the synergism between the components of the volatile oils.
Antimicrobial Properties of Lauric Acid and Monolaurin in Virgin Coconut Oil: A Review
Authors: Nitbani Febri Odel , Tjitda Putra Jiwamurwa Pama , Nitti Fidelis , Jumina J. , Detha Annytha Ina Rohi 
Published: June 2022

AbstractVirgin coconut oil is obtained by wet processing of coconut milk using fermentation, centrifugation, enzymatic extraction, and the microwave heating method. Presently, VCO has several positive effects and benefits to human health, hence, it is regularly consumed and widely known as a unique functional food. VCO contains lauric acid (45 to 52 %). By lipase in the digestive system, VCO can undergo a breakdown into lauric acid, 1‐monolaurin, and 2‐monolaurin. These components have both hydrophilic and lipophilic groups and are also recognized as excellent antimicrobial lipids. Furthermore, lauric acid and monolaurin can be used as antibacterial, antifungal, and antiviral with broad‐spectrum inhibition. Lauric acid and monolaurin have a strong ability to destroy gram‐positive bacteria, especially S. aureus, fungi such as C. Albicans, and viruses including vesicular stomatitis virus (VSV), herpes simplex virus (HSV), and visna virus (VV). Lauric acid and monolaurin interact with certain functional groups located in the cell membrane and can cause damage to the cell. In general, the potential of VCO as healthy food is contributed by lauric acid and monolaurin which are antimicrobial agents.
RING finger protein 128 (RNF128) regulates malignant biological behaviors of colorectal cancer cells via PI3K/AKT signaling pathway
Authors: Zhuang Yan , Liu Peng‐fei , Zhan Yang , Kong Da‐lu , Tian Fei , Zhao Peng 
Published: June 2022

AbstractThis study was designed and conducted to clarify the impact of RNF128 expression on malignant biological behaviors of colorectal cancer (CRC) cells and the underlying mechanism. The expression of RNF128 in CRC tissues was analyzed using mRNA sequencing data of TCGA database and was validated by Western blot assay. The experimental studies on biological functions of RNF128 in vitro were conducted to assess its impact on the proliferation, apoptosis, and metastasis of CRC cells. Furthermore, tumor xenograft models in nude mice were established to investigate the relationship between RNF128 expression and tumor growth in vivo. The expression levels of both RNF128 mRNA and protein were significantly increased in CRC tissues (p < .001). The knockdown of RNF128 markedly suppressed the malignant phenotype of HCT116 and SW480 cells in vitro, including cell growth, antiapoptosis, migration, and invasion (p < .001). On the other hand, knockdown of RNF128 exerted a remarkable effect on the growth inhibition of tumor xenografts in vivo (p < .001). Further investigation revealed that RNF128 knockdown lead to a significant decrease in the expression of p‐AKT and p‐PI3K protein. More importantly, the proliferative, antiapoptotic, metastatic abilities of RNF128‐knockdown cells were markedly increased by 740 Y‐P treatment (p < .001). These findings further suggested that PI3K/AKT signaling pathway played a key role in RNF128‐mediated aggressive phenotype of CRC cells. RNF128 functions as a tumor promoter in the pathogenesis of CRC via regulating PI3K/AKT pathway, and it could be a valuable target for CRC treatment.
Automation of intracoronary continuous thermodilution for absolute coronary flow and microvascular resistance measurements
Authors: Candreva Alessandro , Gallinoro Emanuele , Fernandez Peregrina Estefania , Sonck Jeroen , Keulards Danielle C. J. , van‘t Veer Marcel , Mizukami Takuya , Pijls Nico H. J. , Collet Carlos , De Bruyne Bernard 
Published: June 2022

AbstractAimMicrovascular resistance reserve (MRR) as derived from continuous intracoronary thermodilution specifically quantifies microvasculature function. As originally described, the technique necessitates reinstrumentation of the artery and manual reprogramming of the infusion pump when performing resting and hyperemic measurements. To simplify and to render this procedure operator‐independent, we developed a fully automated method. The aim of the present study is to validate the automated procedure against the originally described one.Methods and ResultsFor the automated procedure, an infusion pump was preprogrammed to allow paired resting‐hyperemic thermodilution assessment without interruption. To validate the accuracy of this new approach, 20 automated measurements were compared to those obtained in the same vessels with conventional paired resting‐hyperemic thermodilution measurements (i.e., with a sensor pullback at each infusion rate and manual reprogramming of the infusion pump). A close correlation between the conventional and the automated measuring technique was found for resting flow (Qrest: r = 0.89, mean bias = 2.52; SD = 15.47), hyperemic flow (Qhyper: r = 0.88, mean bias = −2.65; SD = 27.96), resting microvascular resistance (Rμ‐rest: r = 0.90, mean bias = 52.14; SD = 228.29), hyperemic microvascular resistance Rμ‐hyper: r = 0.92, mean bias = 12.95; SD = 57.80), and MRR (MRR: r = 0.89, mean bias = 0.04, SD = 0.59). Procedural time was significantly shorter with the automated method (5′25″ ± 1′23″ vs. 4′36″ ± 0′33″, p = 0.013).ConclusionContinuous intracoronary thermodilution‐derived measurements of absolute flow, absolute resistance, and MRR can be fully automated. This further shortens and simplifies the procedure when performing paired resting‐hyperemic measurements.
Limitations of the L3 skeletal muscle index and the Asian Working Group for Sarcopenia 2019 consensus diagnostic criteria for sarcopenia evaluation in a case of diffuse large B‐cell lymphoma
Authors: Matsunaga Takuya , Deto Tomoko , Yamada Tomoe , Yamamoto Takashi , Yamakawa Kimika , Kamiyama Yuta , Morimoto Masako , Seki Hitoshi , Haraguchi Fumihiko , Hisatomi Ikuko , Nakanishi Katsuya , Takahashi Masahiro 
Published: June 2022

AbstractSarcopenia is an adverse prognostic factor for diffuse large B‐cell lymphoma. A case of diffuse large B‐cell lymphoma whose diagnosis, severity, and therapeutic effect of sarcopenia were difficult to determine owing to lymphoma cell infiltration into the psoas major and femoral bone marrow is reported. At presentation, the cross‐sectional area of left psoas major at L3 was enlarged owing to lymphoma cell infiltration; thus, sarcopenia evaluation was impossible by L3 skeletal muscle index. The patient was bedridden; thus, sarcopenia evaluation was impossible by the Asian Working Group for Sarcopenia 2019 consensus diagnostic criteria at presentation. At the terminal stage, she could not walk due to bilateral anterior thigh pain caused by lymphoma infiltration into femoral marrow; thus, sarcopenia evaluation was impossible by the Asian Working Group for Sarcopenia 2019 consensus diagnostic criteria. Although the L3 skeletal muscle index and the Asian Working Group for Sarcopenia 2019 consensus diagnostic criteria are representative sarcopenia evaluation systems, they cannot be used to evaluate sarcopenia in some diffuse large B‐cell lymphoma patients.
Extraocular sebaceous carcinoma in a renal transplant patient: A case report
Authors: Frioui Refka , Rabhi Faten , Gargouri Faten , Jaber Kahena , Dhaoui Mohamed Raouf 
Published: June 2022

AbstractThe high risk of skin cancer after organ transplantation is a major clinical challenge. We describe a case of a patient presenting with sebaceous carcinoma (SC) after a kidney transplant. Although it is exceedingly rare, SC should always be considered in the presence of any skin lesion occurring after a transplant.
Atmosphere‐free activation methodology for holey graphene/cellulose nanofiber‐based film electrode with highly efficient capacitance performance
Authors: Wu Heng , Yuan Wenyu , Yuan Xiaowen , Cheng Laifei 
Published: June 2022

AbstractAn efficient chamber‐induced activation method was applied for the preparation of holey graphene/cellulose nanofiber‐based film with high specific surface area (SSA) and multiple channels through the graphene nanosheets. With the cellulose nanofiber (CNF) simultaneously serving as “dispersing agent,” “spacer,” and “activating agent,” the graphene oxide (GO) nanosheets are perforated by the pyrolysis gas from CNF in the confined space inside the hybrid films, uniformly dispersed, and sandwiched between CNF networks with less agglomeration and restacking. Additionally, we have proved that H2O and H2 are primarily responsible for the activation and etching of GO/CNF film. As the CNF content increases, the mesoporosity of the activated reduced GO/CNF (A‐RGO/CNF) film increases, and the graphene nanosheets show more nanopore perforations. Benefitting from the high SSA, high density, moderate mesoporosity, and abundant channels for ion diffusion through the graphene nanosheets, the A‐RGO/CNF film exhibits the highest specific capacitance of 323 (236) F g−1 (F cm−3) at 1 A g−1. For the A‐RGO5/CNF5 film containing half CNF and half GO, an excellent comprehensive electrochemical performance including superior rate performance (208 (160) F g−1 (F cm−3) at 60 A g−1) is exhibited. Moreover, the A‐RGO5/CNF5 electrode in an all‐solid‐state flexible symmetric supercapacitor delivers a high specific capacitance of 250 (193) F g−1 (F cm−3) at 1 A g−1. This study provides a novel idea for the preparation of holey graphene‐based film for supercapacitor electrodes. The strategy of simultaneously employing CNF as “dispersing agent,” “spacer,” and “activating agent” also offers a new vision for the assembly of homogeneous nanohybrid material and the utilization of pyrolysis gas.
Single‐Step N‐Terminal Modification of Proteins via a Bio‐Inspired Copper(II)‐Mediated Aldol Reaction
Authors: Hanaya Kengo , Yamoto Kaho , Taguchi Kazuaki , Matsumoto Kazuaki , Higashibayashi Shuhei , Sugai Takeshi 
Published: June 2022

AbstractThe chemical modification of proteins is an effective technique for manipulating the properties and functions of proteins, and for creating protein‐based materials. The N‐terminus is a promising target for single‐site modification that provides modified proteins with uniform structures and properties. In this paper, a copper(II)‐mediated aldol reaction with 2‐pyridinecarboxaldehyde (2‐PC) derivatives is proposed as an operationally simple method to selectively modify the N‐terminus of peptides and proteins at room temperature and physiological pH. The copper(II) ion activates the N‐terminal amino acids by complexation with an imine of the N‐terminal amino acid and 2‐PCs, realizing the selective formation of the nucleophilic intermediate at the N‐terminus. This results in a stable carbon‐carbon bond between the 2‐PCs and the α‐carbon of various N‐terminal amino acids. The reaction is applied to four different proteins, including biopharmaceuticals such as filgrastim and trastuzumab. The modified trastuzumab retains the human epidermal growth factor receptor 2 recognition activity.
Machine learning‐based gene alteration prediction model for primary lung cancer using cytologic images
Authors: Ishii Shuhei , Takamatsu Manabu , Ninomiya Hironori , Inamura Kentaro , Horai Takeshi , Iyoda Akira , Honma Naoko , Hoshi Rira , Sugiyama Yuko , Yanagitani Noriko , Mun Mingyon , Abe Hitoshi , Mikami Tetuo , Takeuchi Kengo 
Published: June 2022

AbstractBackground: Understanding the gene alteration status of primary lung cancers is important for determining treatment strategies, but gene testing is both time‐consuming and costly, limiting its application in clinical practice. Here, potential therapeutic targets were selected by predicting gene alterations in cytologic specimens before conventional gene testing.Methods: This was a retrospective study to develop a cytologic image–based gene alteration prediction model for primary lung cancer. Photomicroscopic images of cytology samples were collected and image patches were generated for analyses. Cancer‐positive (n = 106) and cancer‐negative (n = 32) samples were used to develop a neural network model for selecting cancer‐positive images. Cancer‐positive cases were randomly assigned to training (n = 77) and validation (n = 26) data sets. Another neural network model was developed to classify cancer images of the training data set into 4 groups: anaplastic lymphoma kinase (ALK)‐fusion, epidermal growth factor receptor (EGFR), or Kirsten rat sarcoma viral oncogene homologue (KRAS) mutated groups, and other (None group), and images of the validation data set were classified. A decision algorithm to predict gene alteration for cases with 3 probability ranks was developed.Results: The accuracy and precision for selecting cancer‐positive patches were 0.945 and 0.991, respectively. Predictive accuracy for the EGFR and KRAS groups in the validation data set was ~0.95, whereas that for the ALK and None groups was ~0.75 and ~ 0.80, respectively. Gene status was correctly predicted in the probability rank A cases. The model extracted characteristic conventional cytologic findings in images and a novel specific feature was discovered for the EGFR group.Conclusions: A gene alteration prediction model for lung cancers by machine learning based on cytologic images was successfully developed.