bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second allogeneic hematopoietic stem cell transplantation in patients with inborn errors of immunity
Authors: Laberko Alexandra , Sultanova Elvira , Idarmacheva Aishat , Skvortsova Yulia , Shelikhova Larisa , Nechesnyuk Alexei , Kobyzeva Daria , Shcherbina Anna , Maschan Michael , Maschan Alexei , Balashov Dmitry 
Published: December 2022

AbstractGraft failure (GF) remains a serious issue of hematopoietic stem cell transplantation (HSCT) in inborn errors of immunity (IEI). Second HSCT is the only salvage therapy for GF. There are no uniform strategies for the second HSCTs and limited data are available on the second HSCT outcomes. 48 patients with various IEI received second allogeneic HSCT from 2013 to 2020. Different conditioning regimens were used, divided into two main groups: containing myeloablative doses of busulfan/treosulfan (n = 19) and lymphoid irradiation 2–6 Gy (n = 22). Irradiation-containing conditioning was predominantly used in suspected immune-mediated rejection of the first graft. Matched unrelated donor was used in 28 patients, mismatched related in 18, and matched related in 1. 35 patients received TCRαβ/CD19 graft depletion. The median follow-up time was 2.4 years post-HSCT. One patient died at conditioning. The OS was 0.63 (95% CI: 0.41–0.85) after busulfan/treosulfan and 0.68 (95% CI: 0.48–0.88) after irradiation-based conditioning,p = 0.66. Active infection at HSCT significantly influenced OS: 0.43 (95% CI: 0.17–0.69) versus 0.73 (95% CI: 0.58–0.88) without infection,p = 0.004. The cumulative incidence of GF was 0.15 (95% CI: 0.08–0.29). To conclude, an individualized approach is required for the second HSCT in IEI. Low-dose lymphoid irradiation in suspected immune-mediated GF may be a feasible option.
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring
Authors: Ashton Nicholas J. , Janelidze Shorena , Mattsson-Carlgren Niklas , Binette Alexa Pichet , Strandberg Olof , Brum Wagner S. , Karikari Thomas K. , González-Ortiz Fernándo , Di Molfetta Guglielmo , Meda Francisco J. , Jonaitis Erin M. , Koscik Rebecca Langhough , Cody Karly , Betthauser Tobey J. , Li Yan , Vanmechelen Eugeen , Palmqvist Sebastian , Stomrud Erik , Bateman Randall J. , Zetterberg Henrik , Johnson Sterling C. , Blennow Kaj , Hansson Oskar 
Published: December 2022

AbstractBlood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for the identification of AD pathology or monitoring of disease progression. Blood biomarkers that correlate with changes in cognition and atrophy during the course of the disease could be used in clinical trials to identify successful interventions and thereby accelerate the development of efficient therapies. When disease-modifying treatments become approved for use, efficient blood-based biomarkers might also inform on treatment implementation and management in clinical practice. In the BioFINDER-1 cohort, plasma phosphorylated (p)-tau231 and amyloid-β42/40 ratio were more changed at lower thresholds of amyloid pathology. Longitudinally, however, only p-tau217 demonstrated marked amyloid-dependent changes over 4–6 years in both preclinical and symptomatic stages of the disease, with no such changes observed in p-tau231, p-tau181, amyloid-β42/40, glial acidic fibrillary protein or neurofilament light. Only longitudinal increases of p-tau217 were also associated with clinical deterioration and brain atrophy in preclinical AD. The selective longitudinal increase of p-tau217 and its associations with cognitive decline and atrophy was confirmed in an independent cohort (Wisconsin Registry for Alzheimer’s Prevention). These findings support the differential association of plasma biomarkers with disease development and strongly highlight p-tau217 as a surrogate marker of disease progression in preclinical and prodromal AD, with impact for the development of new disease-modifying treatments.
Trueness of intraoral scanners according to subgingival depth of abutment for fixed prosthesis
Authors: Son Young-Tak , Son KeunBaDa , Lee Kyu-Bok 
Published: December 2022

AbstractThis study aimed to compare the trueness of intraoral scanners (IOSs) according to the subgingival finish line depth of tooth preparation for fixed prostheses. The prepared maxillary right first molar was fabricated by using ceramic material. A computer-aided design (CAD) reference model (CRM) of the abutment was obtained by using a contact scanner. The subgingival finish line was located according to the depth at 0-mm, 0.25-mm, 0.5-mm, 0.75-mm, and 1-mm. CAD test models (CTMs) were obtained by using 2 IOSs (i500 and CS3600). CRM and CTM were superimposed and analyzed (Geomagic control X). The one-way analysis of variance (ANOVA) was used to compare the trueness according to the subgingival finish line depth. The paired t test was used to compare the trueness of IOSs with and without gingival retraction (α = .05). When the gingival displacement code was not used, it was observed that the trueness of both IOSs decreased significantly as the depth of the subgingival finish line increased (P < 0.001). When the subgingival finish line was positioned deeper than 0.5-mm, the trueness of both IOSs exceeded 100 µm in the marginal region. When the gingival displacement cord was used, the trueness of both IOSs did not exceed 100 µm regardless of the subgingival finish line depth. When gingival cord was used, it showed significantly higher trueness than when not used (P < 0.001). When the gingival displacement cord was not used, the trueness of IOSs decreased as the subgingival finish line depth increased. But the use of the gingival displacement cord improved the scanning trueness by 90%. Thus, it is necessary to use the gingival displacement cord according to the clinical situation to improve scan trueness at the subgingival finish line.
Increasing buffering capacity enhances rumen fermentation characteristics and alters rumen microbiota composition of high-concentrate fed Hanwoo steers
Authors: Ramos Sonny C. , Kim Seon Ho , Jeong Chang Dae , Mamuad Lovelia L. , Son A-Rang , Kang Seung Ha , Cho Yong Il , Kim Tae Gyu , Lee Jin Sung , Cho Kwang Keun , Lee Sung Sill , Lee Sang Suk 
Published: December 2022

AbstractThe buffering capacity of buffer agents and their effects on in vitro and in vivo rumen fermentation characteristics, and bacterial composition of a high-concentrate fed Hanwoo steers were investigated in this study. Treatments were comprised of CON (no buffer added), BC0.3%(low buffering capacity, 0.3% buffer), BC0.5%(medium buffering capacity, 0.5% buffer), and BC0.9%(high buffering capacity, 0.9% buffer). Four Hanwoo steers in a 4 × 4 Latin square design were used for the in vivo trial to assess the effect of treatments. Results on in vitro experiment showed that buffering capacity, pH, and ammonia–nitrogen concentration (NH3-N) were significantly higher in BC0.9%and BC0.5%than the other treatments after 24 h incubation. Individual and total volatile fatty acids (VFA) concentration of CON were lowest compared to treatment groups. Meanwhile, in vivo experiment revealed that Bacteroidetes were dominant for all treatments followed by Firmicutes and Proteobacteria. The abundances ofBarnesiella intestinihominis, Treponema porcinum,andVibrio marisflaviwere relatively highest under BC0.9%,Ruminoccocus bromiiandSucciniclasticum ruminisunder BC0.5%, andBacteroides massiliensisunder BC0.3%.The normalized data of relative abundance of observed OTUs’ representative families have grouped the CON with BC0.3%in the same cluster, whereas BC0.5%and BC0.9%were clustered separately which indicates the effect of varying buffering capacity of buffer agents. Principal coordinate analysis (PCoA) on unweighted UniFrac distances revealed close similarity of bacterial community structures within and between treatments and control, in which BC0.9%and BC0.3%groups showed dispersed community distribution. Overall, increasing the buffering capacity by supplementation of BC0.5%and and BC0.9%buffer agents enhanced rumen fermentation characteristics and altered the rumen bacterial community, which could help prevent ruminal acidosis during a high-concentrate diet.
Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial
Authors: Fukushima Munehisa , Akahani Shiro , Okamoto Hidehiko , Takeda Noriaki , Inohara Hidenori 
Published: December 2022

AbstractMénière’s disease (MD) is an inner ear disorder in which the main pathological feature is endolymphatic hydrops (EH). Positive pressure therapy (PPT) using a portable device is now a second-line therapy for intractable MD when initial medical treatment fails. However, it remains unknown whether PPT causes the morphological and functional changes of inner ear in patients with active MD in accordance with reduction of vertigo attacks. In this nonrandomized controlled trial of 52 patients with MD, the volume of EH significantly decreased with reduction of vertigo attacks during 8 months of PPT combined with medications while the volume of that significantly increased with medications alone. There was no difference between Control group (n = 26) and PPT group (n = 26) regarding the vertigo control, however, PPT group achieved a significant functional improvement of vertical semicircular canals. The effect of volume reduction by PPT has been firstly demonstrated and the functional changes of all semicircular canals during PPT have been firstly examined. Morphological and functional changes in the inner ear by administrating local positive pressure are quite different from those caused by medications alone.Clinical trial registration: UMIN-CTR UMIN000041164 (registered on July 20, 2020).
Enhancement of the properties of ZnAl-LDHs for photocatalytic nitrogen reduction reaction by controlling anion intercalation
Authors: Su Senda , Li Xiaoman , Tan Mengyao , Zhang Xu , Wang Yingying , Duan Yanzhong , Peng Juan , Luo Min 
Published: December 2022

The anion regulated channel of LDHs blocked by carbonate was opened by controlling the suberate intercalation, thus discussing the effect of different anions of PMo12−XVX, X = 0, 1, 2, 3, 8) intercalation on the photocatalytic nitrogen fixation performance of ZnAl-LDH.
Multi-objective optimization algorithms applied to residential building retrofitting at district scale: BRIOTOOL
Authors: Hernández-Moral Gema , Serna-González Víctor Iván , Crespo Alejandro Martín , Rodil Sergio Saludes 
Published: December 2022

The design of district and urban energy efficient retrofitting projects is a major challenge if contrasted solutions want to be implemented. From the establishment of the criteria to the calculation of indicators, there are several aspects to be considered, such as evaluating a series of refurbishment solutions or establishing an adequate method to select the optimal solution. Apart from this process requiring a high number of time and resources, it can result in a number of inaccuracies, leading to inadequate decisions or designs.
The main achievement of the BRIOTOOL solution proposed is the transformation of a subjective problem (what the best combination of energy conservation measures to implement is) into a mathematical problem, which ensures a more robust decision-making process. In particular, by analysing which multi-objective optimization method (NSGA-II, IHS, MHACO or NSPSO) is the most appropriate, based on execution time, number of different and optimal solutions, and hypervolume of the Pareto front generated.
As a result, the time reduction and the increase in the accuracy of the process compared to business as usual practices shows the benefits of the solution in designing energy efficient retrofitting projects at district level.
Radiopraxis
Authors: Huber Evelyn 
Published: December 2022

Liebe Leserinnen und Leser,als ich von der Thieme-Projektmanagerin die Einladung zum Verfassen dieses Editorials
bekam, musste ich schmunzeln. Zwei CPD-Artikel sowie ein Artikel in der Rubrik Aus-
und Weiterbildung haben arbeits- bzw. ausbildungstechnisch Grazer Wurzeln. Ich bin
mittlerweile schon seit über 10 Jahren in der Hochschullehre und Forschung
tätig und der Bedarf an Radiologietechnolog*innen in
Österreich steigt, wie auch in anderen Ländern, rasant. Es freut
mich, dass ich als Bildungsbeauftragte Studierenden Wissen vermitteln, praktische
Erfahrungen weitergeben und ihre Entwicklung begleiten darf. Ich bin stolz, wenn
sich diese – auch Jahre nach ihrem erfolgreichen Studiums- und
Ausbildungsabschluss – bereit erklären, einen Artikel für
die Radiopraxis zu verfassen. Denn schlussendlich haben sie während des
Studiums und auch in der Berufswelt vom Wissen erfahrener Berufskolleg*innen
profitiert und erkannt, dass sie bereits so viel Wissen/Erfahrungen
gesammelt haben, dass sie dieses wiederum weitergegeben können. Im
Fachjargon wird von Wissenstransfer gesprochen. Wenn durch die Interaktion von
implizitem (z. B. Erfahrungs-/Praxiswissen) und explizitem Wissen
(z. B. Theoriewissen) neues Wissen geschaffen wird, wird dies als
Wissensspirale bezeichnet.
Editorial
Authors: Stefanski Ana-Luisa , Dörner Thomas 
Published: December 2022

Liebe Kolleginnen und KollegenGemeinsam mit allen Autoren des vorliegenden Heftes, freuen wir uns, Ihnen aktuelle
Aspekte zu Veränderungen im Bereich der Gerinnung bei entzündlich
rheumatischen Erkrankungen vorzustellen. Die Komplexität im Bereich der
Rheumatologie beinhaltet unterschiedliche Aktivierungszustände des
Immunsystems, welche über humorale und zelluläre Mechanismen im
Rahmen der Körperabwehr auch mit Gerinnungsaktivierung einhergehen
können. Gut bekannt sind die Arthropathie bei Hämophiliepatienten,
bei denen die sog. „Annual Bleeding Rates“ in Gelenke durch
adäquate Faktorensubstution und schließlich den
Möglichkeiten der Gentherapien revolutionär erniedrigt wurden.
Das Erleben Geistlicher Trockenheit als Glaubens- und Lebenskrise und ihre Bedeutung für die psychotherapeutische Begleitung
Authors: Büssing Arndt 
Published: December 2022

ZUSAMMENFASSUNGManche Lebenskrisen sind so tiefgreifend, dass sie einer professionellen psychotherapeutischen Begleitung bedürfen. Und manche Glaubenskrisen sind so belastend, dass sie einer psychotherapeutischen und geistlichen Begleitung sowie Einordnung bedürfen, um sie von der Depression abgrenzen zu können. In der Tat gibt es eine Schnittmenge zwischen dem Erleben von Phasen „Geistlicher Trockenheit“ als Ausdruck einer spezifischen Form der religiösen Verunsicherung einerseits und depressiver Gestimmtheit, emotionaler Erschöpfung sowie Verlust einer Lebensstimmigkeit andererseits. Das Erleben solcher geistlichen „Wüsten- und Dürrezeiten“ soll ausdrücklich nicht pathologisiert werden. Nicht jede Phase Geistlicher Trockenheit ist eine Depression und nicht jede Depression ist Ausdruck einer „Dunklen Nacht der Seele“ im Sinne eines „Läuterungsprozesses“, wie es der Mystiker des Mittelalters Johannes vom Kreuz beschrieb. In diesem Beitrag soll es um die Einordnung und Nachvollziehbarkeit des Erlebens gehen. Hierfür werden empirische Daten und qualitative Befunde erörtert.
Die Rolle von Religiosität und Spiritualität im Umgang mit der Erkrankung bei psychiatrischen Patienten in Kroatien und Bosnien und Herzegowina
Authors: Glavas Andrijana , Büssing Arndt , Baumann Klaus 
Published: December 2022

ZUSAMMENFASSUNGIm Rahmen einer Querschnittserhebung in den Universitätskliniken von Zagreb (HR) und Sarajevo (BiH) unter Patienten mit PTBS und anderen Traumafolgeerkrankungen (TFE) sowie anderen psychischen Erkrankungen (n = 353) gehen wir der Frage nach, wie die Religiosität/Spiritualität (R/S) der Betroffenen und die empfundene Krankheitsbelastung zusammenhängen. Es zeigte sich, dass die Krankheitsbelastung bei Personen mit TFE signifikant höher war als mit anderen psychischen Erkrankungen. Zwischen ihnen besteht kein signifikanter Unterschied in der Nutzung ihrer R/S als Ressource im Umgang mit ihrer Erkrankung (SpREUK-Fragebogen). Die SpREUK-Faktoren unterscheiden sich jedoch signifikant in Abhängigkeit von der Behandlungsdauer. Wer nicht aktiv am Krieg teilnahm suchte weit mehr nach einer spirituellen Ressource, hatte größeres religiöses Vertrauen und sah Krankheit deutlich eher als eine Chance für (mögliche) Veränderung im eigenen Leben als die Kriegsteilnehmer. Bei Personen mit TFE-korreliert die Stärke der Krankheitsbelastung moderat (r > 0,40) mit allen 3 SpREUK-Faktoren, wohingegen dies nur schwach bei Personen mit anderen psychisch Erkrankten der Fall ist. Bei aktiver Kriegsteilnahme korreliert eine höhere subjektive Krankheitsbelastung ähnlich (moderat) mit einer stärkeren Suche und mehr religiösem Vertrauen in, schwächer hingegen mit der Reflexion. Die Rolle der R/S im Umgang mit der eigenen Erkrankung kann zeitlichen und biografischen Schwankungen bzw. dynamischen Entwicklungen unterliegen, bedeutet aber für die meisten eine bedeutsame Ressource. Ihre Beachtung im therapeutischen Prozess birgt über die beiden Länder hinaus Potenziale für Public Health.
Catalytic Enantioselective Inverse-Electron-Demand Diels–Alder Reaction of 2-Pyrones and Vinyl Selenides
Authors: Cai Quan , You Xin-Yu 
Published: December 2022

AbstractWe report an asymmetric inverse-electron-demand Diels–Alder reaction of electron-deficient 2-pyrones with various phenyl vinyl selenides catalyzed by a chiral bis(oxazoline)/Cu(OTf)2 complex. By using a side-arm-modified chiral bis(oxazoline)ligand, a variety of [2,2,2]-bicyclic lactones with phenyl selenide substituents were obtained in good to excellent yields (up to 99%) and enantioselectivities (up to 98% ee) under mild conditions. Based on this strategy, a highly concise enantioselective synthesis of the Corey lactone was accomplished.
Trends in Attempted Vaginal Delivery among Pregnancies Complicated by Gastroschisis, 2014 to 2020
Authors: Schmidt Christina N. , Wen Timothy , Friedman Alexander M. , D'Alton Mary E. , Andrikopoulou Maria 
Published: December 2022

Objective Gastroschisis is a full-thickness congenital defect of the abdominal wall through which intestines and other organs may herniate. In a prior analysis, attempted vaginal delivery with fetal gastroschisis appeared to increase through 2013, although cesarean delivery remained common. The objective of this analysis was to update current trends in attempted vaginal birth among pregnancies complicated by gastroschisis.
Study Design We performed an updated cross-sectional analysis of live births from 2014 and 2020 using data from the U.S. National Vital Statistics System and evaluated trends in attempted vaginal deliveries among births with gastroschisis. Trends were evaluated using joinpoint regression. We constructed logistic regression models to evaluate the association between demographic and clinical variables and attempted vaginal delivery in the setting of gastroschisis.
Results Among 5,355 deliveries with gastroschisis meeting inclusion criteria, attempted vaginal delivery increased significantly from 68.9% to 75.1%, an average annual percent change of 1.7% (95% confidence interval [CI], 0.8–2.5). Among gastroschisis-complicated pregnancies, patients 35 to 39 years old (adjusted odds ratio [aOR], 0.53; 95% CI, 0.37–0.79) and Hispanic race/ethnicity (aOR, 0.69; 95% CI, 0.58–0.62) were at lower likelihood of attempted vaginal delivery in adjusted analyses.
Conclusion These findings suggest that vaginal delivery continues to increase in the setting of gastroschisis. Further reduction of surgical delivery for this fetal defect may be possible.
Key Points
The Synthetic Approaches to 1,2-Chlorohydrins
Authors: Hilt Gerhard 
Published: December 2022

AbstractThis short review highlights the hitherto realised synthetic approaches towards organic 1,2-chlorohydrins by functionalisation of alkenes (i.e., 1,2-chlorohydroxylation), which is the most prominent access route to this class of compounds. Also, some other synthetic approaches involving the reduction of α-chloroketones, the epoxide opening ring by chloride anions and the utilisation of Grignard reagents for the synthesis of these compounds and chlorination of allylic alcohols are highlighted. Finally, enzymatic reactions for the formation of chlorohydrins are briefly summarised followed by a short view on natural products containing this moiety.1	Introduction2	Applications for the Synthesis of 1,2-Chlorohydrins2.1	Chlorohydroxylation of Alkenes2.2	Reduction of Chloroketones2.3	Metalorganic Reagents2.4	Epoxide Ring Opening2.5	Chlorination of Allylic Alcohols2.6	Biochemical Methods2.7	Selected Applications in Natural Product Total Synthesis3	Conclusion
Sensitivity and Specificity of the Newborn Infant Parasympathetic Evaluation Index in Pain Assessment of Very Low Birth Weight Infants
Authors: Uberos Jose , Campos-Martinez Ana , Ruiz-López Aida , Fernandez-Marín Elizabeth , García-Serrano Jose Luis 
Published: December 2022

Objective This article describes the results of a study investigating the sensitivity and specificity of the Newborn Infant Parasympathetic Evaluation (NIPE) index for detecting the physiological changes resulting from nociception in painful procedures in very low birth weight (VLBW) infants.
Study Design A prospective observational study was carried on of 44 newborns at 23 to 32 weeks' gestational age. The sensitivity and specificity of the NIPE index are analyzed using a receiver operating characteristic curve. Most of the painful procedures performed were skin-lancing and venipunctures. Nonpainful procedures consist of no intervention, with an interval of at least 1 hour with painful procedures in each newborn.
Results The accuracy of the NIPE index to diagnose mild nociceptive stimulation in VLBW newborns is 73.2%.
Conclusion The NIPE index is a useful technique for assessing nociceptive stimulation in newborns, presenting less observer-dependent variability than other pain assessment scales.
Key Points