bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intestinal inflammation and increased intestinal permeability in Plasmodium chabaudi AS infected mice
Authors: Mooney Jason P , DonVito Sophia M , Lim Rivka , Keith Marianne , Pickles Lia , Maguire Eleanor A , Wagner-Gamble Tara , Oldfield Thomas , Bermejo Pariente Ana , Ehimiyein Ajoke M , Philbey Adrian A , Bottomley Christian , Riley Eleanor M , Thompson Joanne 
Published: October 2022

Background: Gastrointestinal symptoms are commonly associated with acute Plasmodium spp infection. Malaria-associated enteritis may provide an opportunity for enteric pathogens to breach the intestinal mucosa, resulting in life-threatening systemic infections. Methods: To investigate whether intestinal pathology also occurs during infection with a murine model of mild and resolving malaria, C57BL/6J mice were inoculated with recently mosquito-transmitted Plasmodium chabaudi AS. At schizogony, intestinal tissues were collected for quantification and localisation of immune mediators and malaria parasites, by PCR and immunohistochemistry. Inflammatory proteins were measured in plasma and faeces and intestinal permeability was assessed by FITC-dextran translocation after oral administration. Results: Parasitaemia peaked at approx. 1.5% at day 9 and resolved by day 14, with mice experiencing significant and transient anaemia but no weight loss. Plasma IFNγ, TNFα and IL10 were significantly elevated during peak infection and quantitative RT-PCR of the intestine revealed a significant increase in transcripts for ifng and cxcl10. Histological analysis revealed parasites within blood vessels of both the submucosa and intestinal villi and evidence of mild crypt hyperplasia. In faeces, concentrations of the inflammatory marker lactoferrin were significantly raised on days 9 and 11 and FITC-dextran was detected in plasma on days 7 to 14. At day 11, plasma FITC-dextran concentration was significantly positively correlated with peripheral parasitemia and faecal lactoferrin concentration. Conclusions: In summary, using a relevant, attenuated model of malaria, we have found that acute infection is associated with intestinal inflammation and increased intestinal permeability. This model can now be used to explore the mechanisms of parasite-induced intestinal inflammation and to assess the impact of increased intestinal permeability on translocation of enteropathogens.
Clinical efficacy and neurobiological correlates of electroconvulsive therapy in patients with clozapine-resistant/intolerant schizophrenia: study protocol of multi-site parallel arm double-blind randomized sham-controlled study
Authors: Arumugham Shyam Sundar , Praharaj Samir K. , Shreekantiah Umesh , Sreeraj Vanteemar S. , Roy Chandramouli , Shenoy Sonia , Purohith Abhiram Narasimhan , Chithra Uppinkudru , Bagali Kiran Basawaraj , Venkataramaiah Sudhir , Nanjundaiah Gopala Krishna Kadarapura , Thennarasu Kandavel , Kumar Channaveerachari Naveen , Goyal Nishant , Das Basudeb , Mehta Urvakhsh Meherwan , Muralidharan Kesavan , Venkatasubramanian Ganesan , Sinha Preeti , Thirthalli Jagadisha 
Published: October 2022

Background: A substantial proportion of patients with treatment resistant schizophrenia do not respond well or partially to clozapine, with a subset that does not tolerate an adequate trial of clozapine. Electroconvulsive therapy (ECT) is regarded as one of the augmenting options, but there is a lack of high-quality evidence for this practice. This protocol describes a double-blind randomised sham-controlled modified-ECT trial to evaluate its efficacy in patients with clozapine resistant/intolerant schizophrenia. The study also involves multimodal investigations to identify the response predictors and the mechanistic basis of modified ECT in this population. Methods: One hundred consenting schizophrenia patients with resistance/intolerance to clozapine referred by clinicians for ECT would be randomly assigned to receive true ECT or sham ECT at three study centers. Sham ECT would mimic all the procedures of modified ECT including anaesthesia and muscle relaxation, except the electrical stimulation. After a blinded course, non-responders to sham ECT would be offered open-label true ECT. Clinical assessments, neurocognitive assessments and multimodal investigations (magnetic resonance imaging [MRI], electroencephalography, heart rate variability, investigative transcranial magnetic stimulation-transcranial direct current stimulation, gene polymorphism) would be conducted at baseline and repeated after the end of the trial, as well as open-label ECT course. The trial would evaluate the improvement in positive symptoms (scale for assessment of positive symptoms) of schizophrenia as the primary outcome measure with prediction of this change by resting-state functional-MRI based brain-connectivity as the second primary objective. Registration: Clinical Trial Registry of India (Reg no: CTRI/2021/05/033775) on 24th May 2021.
Eliminating the influence of modulation depth by a laser interference double detection system
Authors: Tong Kai , Qian Kunmiao , Wang Hui , Wang Tao , Zhang Qianqian 
Published: October 2022

We propose a method of combining a double optical path detection system with a phase generation carrier arctangent algorithm. The feasibility of eliminating the influence of modulation depth by the double optical path detection vibration measurement system is verified by simulation and experiment. Results show that the average total harmonic distortion of the single frequency signal is 1%, and the signal-to-noise ratio of the speech signal is improved by an average of 5.6 dB. Therefore, the double optical path detection system can eliminate the influence of modulation depth, avoid nonlinear distortion, and improve the detection performance of the system.
The role of environmental enteric dysfunction in the pathogenesis of Schistosoma mansoni-associated morbidity in school-aged children
Authors: Araújo Fiuza Jacqueline , Colt Susannah , Gambogi de Ornellas Letícia , Ferreira Matoso Leonardo , Gazzinelli Andrea , Friedman Jennifer F. , Corrêa-Oliveira Rodrigo 
Published: October 2022

BackgroundStudies have implicated schistosomiasis as a cause of intestinal barrier disruption, a salient feature of environmental enteric dysfunction (EED), as eggs translocate from the sterile bloodstream through the gut wall. We examined the longitudinal impact of praziquantel (PZQ) treatment on a) EED biomarkers and b) Insulin growth factor I (IGF-1), a key driver of childhood linear growth, since EED has been implicated in linear growth stunting.Methodology290 children infected withS.mansoniin Brazil were treated with PZQ at baseline. EED biomarkers lipopolysaccharide (LPS) and intestinal fatty acid binding-protein (I-FABP) were measured, as well as IGF-1 at baseline, 6 and 12-months. Multivariate regression analysis was applied to assess associations betweenS.mansoniintensity and plasma biomarkers (LPS, I-FABP, and IGF-1), controlling for potential confounding variables.Principal findingsAt baseline,S.mansoniinfection intensities were 27.2% light, 46.9% moderate, and 25.9% heavy. LPS concentrations were significantly reduced at the 12-month visit compared to baseline (p = 0.0002). No longitudinal changes were observed for I-FABP or IGF-1 in the 6- or 12-month periods following baseline treatment. After 6-months, I-FABP concentration was significantly higher in high vs low intensity (p = 0.0017). IGF-1 concentrations were significantly lower among children with high and moderate vs low intensity infections at each study visit.Conclusions/significanceWe report thatS.mansoniinfection impacts LPS, I-FABP and IGF-1. These findings suggest a mechanistic role for EED in schistosomiasis-related morbidities, particularly linear growth.
Comparison of treatment recompression tables for neurologic decompression illness in swine model
Authors: Johnson W. Rainey , Roney Nicholas G. , Zhou Hanbing , Ciarlone Geoffrey E. , Williams Brian T. , Green William T. , Mahon Richard T. , Dainer Hugh M. , Hart Brett B. , Hall Aaron A. 
Published: October 2022

Background
Significant reductions in ambient pressure subject an individual to risk of decompression illness (DCI); with incidence up to 35 per 10,000 dives. In severe cases, the central nervous system is often compromised (>80%), making DCI among the most morbid of diving related injuries. While hyperbaric specialists suggest initiating recompression therapy with either a Treatment Table 6 (TT6) or 6A (TT6A), the optimal initial recompression treatment for severe DCI is unknown.

Methods
Swine were exposed to an insult dive breathing air at 7.06 ATA (715.35 kPa) for 24 min followed by rapid decompression at a rate of 1.82 ATA/min (184.41 kPa/min). Swine that developed neurologic DCI within 1 hour of surfacing were block randomized to one of four United States Navy Treatment Tables (USN TT): TT6, TT6A-air (21% oxygen, 79% nitrogen), TT6A-nitrox (50% oxygen, 50% nitrogen), and TT6A-heliox (50% oxygen, 50% helium). The primary outcome was the mean number of spinal cord lesions, which was analyzed following cord harvest 24 hours after successful recompression treatment. Secondary outcomes included spinal cord lesion incidence and gross neurologic outcomes based on a pre- and post- modified Tarlov assessment. We compared outcomes among these four groups and between the two treatment profiles (i.e. TT6 and TT6A).

Results
One-hundred and forty-one swine underwent the insult dive, with 61 swine meeting inclusion criteria (43%). We found no differences in baseline characteristics among the groups. We found no significant differences in functional neurologic outcomes (p = 0.77 and 0.33), spinal cord lesion incidence (p = 0.09 and 0.07), or spinal cord lesion area (p = 0.51 and 0.17) among the four treatment groups or between the two treatment profiles, respectively. While the trends were not statistically significant, animals treated with TT6 had the lowest rates of functional deficits and the fewest spinal cord lesions. Moreover, across all animals, functional neurologic deficit had strong correlation with lesion area pathology (Logistic Regression, p < 0.01, Somers’ D = 0.74).

Conclusions
TT6 performed as well as the other treatment tables and is the least resource intensive. TT6 is the most appropriate initial treatment for neurologic DCI in swine, among the tables that we compared.
Developing EMR-based algorithms to Identify hospital adverse events for health system performance evaluation and improvement: Study protocol
Authors: Wu Guosong , Eastwood Cathy , Zeng Yong , Quan Hude , Long Quan , Zhang Zilong , Ghali William A. , Bakal Jeffrey , Boussat Bastien , Flemons Ward , Forster Alan , Southern Danielle A. , Knudsen Søren , Popowich Brittany , Xu Yuan 
Published: October 2022

Background
Measurement of care quality and safety mainly relies on abstracted administrative data. However, it is well studied that administrative data-based adverse event (AE) detection methods are suboptimal due to lack of clinical information. Electronic medical records (EMR) have been widely implemented and contain detailed and comprehensive information regarding all aspects of patient care, offering a valuable complement to administrative data. Harnessing the rich clinical data in EMRs offers a unique opportunity to improve detection, identify possible risk factors of AE and enhance surveillance. However, the methodological tools for detection of AEs within EMR need to be developed and validated. The objectives of this study are to develop EMR-based AE algorithms from hospital EMR data and assess AE algorithm’s validity in Canadian EMR data.

Methods
Patient EMR structured and text data from acute care hospitals in Calgary, Alberta, Canada will be linked with discharge abstract data (DAD) between 2010 and 2020 (n~1.5 million). AE algorithms development. First, a comprehensive list of AEs will be generated through a systematic literature review and expert recommendations. Second, these AEs will be mapped to EMR free texts using Natural Language Processing (NLP) technologies. Finally, an expert panel will assess the clinical relevance of the developed NLP algorithms. AE algorithms validation: We will test the newly developed AE algorithms on 10,000 randomly selected EMRs between 2010 to 2020 from Calgary, Alberta. Trained reviewers will review the selected 10,000 EMR charts to identify AEs that had occurred during hospitalization. Performance indicators (e.g., sensitivity, specificity, positive predictive value, negative predictive value, F1 score, etc.) of the developed AE algorithms will be assessed using chart review data as the reference standard.

Discussion
The results of this project can be widely implemented in EMR based healthcare system to accurately and timely detect in-hospital AEs.
Determinants of mammography screening participation–a cross-sectional analysis of the German population-based Gutenberg Health Study (GHS)
Authors: Pokora Roman M. , Büttner Matthias , Schulz Andreas , Schuster Alexander K. , Merzenich Hiltrud , Teifke Andrea , Michal Matthias , Lackner Karl , Münzel Thomas , Zeissig Sylke Ruth , Wild Philipp S. , Singer Susanne , Wollschläger Daniel 
Published: October 2022

Purpose
We investigated the association between social inequality and participation in a mammography screening program (MSP). Since the German government offers mammography screening free of charge, any effect of social inequality on participation should be due to educational status and not due to the financial burden.

Methods
The ‘Gutenberg Health Study’ is a cohort study in the Rhine-Main-region, Germany. A health check-up was performed, and questions about medical history, health behavior, including secondary prevention such as use of mammography, and social status are included. Two indicators of social inequality (equivalence income and educational status), an interaction term of these two, and different covariables were used to explore an association in different logistic regression models.

Results
A total of 4,681 women meeting the inclusion criteria were included. Only 6.2% never participated in the MSP. A higher income was associated with higher chances of ever participating in a mammography screening (odds ratios (OR): 1.67 per €1000; 95%CI:1.26–2.25, model 3, adjusted for age, education and an interaction term of income and education). Compared to women with a low educational status, the odds ratios for ever participating in the MSP was lower for the intermediate educational status group (OR = 0.64, 95%CI:0.45–0.91) and for the high educational status group (0.53, 95%CI:0.37–0.76). Results persisted also after controlling for relevant confounders.

Conclusions
Despite the absence of financial barriers for participation in the MSP, socioeconomic inequalities still influence participation. It would be interesting to examine whether the educational effect is due to an informed decision.
Psychometric properties of the sit-to-stand test for patients with pulmonary hypertension: A systematic review protocol
Authors: Cardoso Natália Lopes , de Sá Joceline Ferezini , do Nascimento Larissa F. E. , Mendes Luciana A. , Bruno Selma , Torres-Castro Rodrigo , Fregonezi Guilherme A. F. , Resqueti Vanessa R. 
Published: October 2022

Background
Pulmonary hypertension (PH) is a complex syndrome characterized by increased pulmonary arterial pressure and classified into five groups, according to dyspnea on exertion and systemic muscle dysfunction. These symptoms can be identified using the sit-to-stand test (STS), which indirectly evaluates exercise tolerance and lower limb muscle strength. Previous studies used the STS in PH; however, psychometric properties to understand and validate this test were not described for patients with PH.

Objective
To evaluate the psychometric properties (validity, reliability, and responsiveness) of different STS protocols in patients with PH.

Methods and analyses
This is a systematic review protocol that will include studies using STS in patients with PH. Searches will be conducted on PubMed/MEDLINE, EMBASE, SciELO, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science databases following PICOT mnemonic strategy and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). Rayyan software will be used for study selection. The Risk of bias will be assessed using the Consensus‐Based Standards for the Selection of Health Measurement Instruments (COSMIN) tool, while the quality of evidence will be assessed using the modified Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Two researchers will independently conduct the study, and a third researcher will be consulted in case of disagreement. The psychometric properties will be evaluated according to the COSMIN. This protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, no. CRD42021244271).

Conclusion
This systematic review will attempt to identify and show the available evidence on STS for different groups of PH and report validity, reliability, and responsiveness of different protocols.
Kebijakan Hukum Pidana Dalam Upaya Penanggulangan Cyber Prostitution
Authors: Safitri Anisya Ines , Makaminan Aldo Andrieyan Putra , Prasetyo Mujiono Hafidh 
Published: October 2022

Bergesernya kehidupan masyarakat ke arah digitalisasi berdampak pada timbulnya kejahatan di dunia siber. Salah satu kejahatan yang menjadi perhatian di masyarakat saat ini adalah prostitusi di dunia siber atau yang biasa dikenal dengan istilah cyber prostitution. Kasus cyber prostitution di Indonesia saat ini masih marak terjadi sampai saat ini sehingga perlunya suatu kebijakan hukum pidana dalam upaya menanggulangi hal tersebut. Tujuan penulisan ini untuk mengkaji kebijakan hukum pidana dalam upaya penanggulangan cyber prostitution berdasarkan hukum positif saat ini dan di masa yang akan datang. Dalam hasil dan pembahasan, pengaturan mengenai cyber prostitution berdasarkan hukum positif saat ini diatur dalam KUHP, UU ITE dan UU Pornografi di mana pengaturan tersebut belum secara tegas mengatur mengenai cyber prostitution. Kebijakan hukum pidana dalam upaya penanggulangan cyber prostitution di Indonesia di masa yang akan datang melalui kajian perbandingan dengan negara lain dan RUU KUHP dapat menjadi acuan untuk pengaturan hukum positif yang lebih baik. Hal ini dikarenakan pengaturan mengenai cyber prostitution sudah semakin tegas karena dalam pengaturan di negara Swedia, yang dapat dikenakan pidana tidak hanya PSK saja tetapi pemakai jasa tersebut juga dapat dipidana. Sedangkan dalam RUU KUHP sudah terjadi perluasan dimana subyek hukumnya lebih diperinci dalam beberapa kelompok.
Jaminan Yang Setara: Mengkalibrasi Kontrak Dan Hukum Waris
Authors: Tedjosaputro Liliana 
Published: October 2022

Perkembangan dunia, banyak perusahaan asuransi bekerjasama dengan perbankan dalam penjualan kredit dengan pengambilan asuransi jiwa. Tulisan ini membahas beda asuransi jiwa dengan hibah wasiat/legaat. dan mengkalibrasi hukum kontrak dan hukum waris sebagai jaminan setara. Metode riset yuridis empiris memakai informasi sekunder selaku informasi utama serta informasi primer selaku informasi pendukung. Hasil penelitian, jaminan yang setara didapat dengan mengkalibrasi hukum kontrak dengan hukum waris sebab dasar asuransi jiwa merupakan kontrak antara pengambil asuransi ataupun pemberi manfaat dengan industri asuransi, jika pemberi manfaat wafat hingga industri asuransi wajib membagikan uang yang diperjanjikan pada penerima manfaat sebab berdasar pada polis asuransi jiwa. Ketentuan pada pewarisan dalam hukum waris bila pewaris meninggal dunia maka harta warisannya akan jatuh pada ahli waris, Bila warisannya tidak mencukupi maka dapat dilakukan inkorting atau inbreng pada legaat atau hibah yang telah diberikan dan juga memenuhi legitime portie kalau dituntut. Kesimpulan, kalau pewaris itu meninggal dunia dalam keadaan pailit dan penerima manfaat itu juga ahli waris maka kurator kepailitan tidak dapat mengambil uang yang diperjanjikan pada penerima manfaat karena yang dipakai adalah hukum perjanjian (polis) bukanlah hukum waris.
Ide Family Group Conference Dalam Sistem Peradilan Pidana Anak Di Indonesia
Authors: Febriansari Kiki Mahendra , Cahyaningtyas Irma 
Published: October 2022

Salah satu upaya pengoptimalan diversi ialah dengan ide pembaharuan melalui Family Group Conference. Family Group Conference adalah model penyelesaian perkara pidana melalui proses pemufakatan bagi anak sebagai pelaku tindak pidana guna menggapai Restorative Justice dalam menyelesaikan masalah anak. Artikel ini membahas tentang ide pembaharuan family group conference serta sebagai sarana untuk mencapai restorative justice dalam sistem peradilan pidana anak di Indonesia. Ide pembaharuan tersebut dapat dilaksanakan melalui pembaharuan Sistem Peradilan Pidana Anak untuk mengoptimalkan restorative justice yang jauh lebih baik, tidak kaku, dan fleksibel yang berlandaskan nilai Pancasila. Metode yang digunakan yaitu metode yuridis normatif, dengan spesifikasi penelitian deskriptif analitis, artikel ini menunjukkan hasil bahwa Family Group Conference dapat diterapkan dalam sistem peradilan pidana anak sebagai ide pembaharuan guna mencapai restorative justice. Family Group Conference dapat menjadi model penyelesaian sistem peradilan pidana anak di masa yang akan datang dengan melibatkan partisipasi aktif keluarga, lembaga pemerhati masalah anak, dan anggota masyarakat yang terlibat.
Empowering Informal Learning and Soft-Skill Enrichment Through an Arts -based Project of Animation among Secondary School Students
Authors: Khir Roselina , Pawanteh Murina , Lajis Ahmad S. , Stephens John 
Published: October 2022

This research aimed to share with educational stake-holders how informal learning through an Arts -based project can contribute to soft-skill enrichment among school learners. The soft skills looked at were based on the 4 C -skills, Creativity, Critical Thinking, Communication and Collaboration. Secondary school students carried out an animation project based on a musical theatre during the Covid -19 pandemic, half of it online, and half through physical meetings. To achieve these objectives, this research used observation, self-reflection and questionnaires to collect data from 13 students and responses from 3 virtual critics. The analysis method used for this research was descriptive analysis. The results showed that specific arts ensemble activity such as creating a performance or animation is able to produce high level of generalized group production skills. The module can be used as indicators for future arts project collaboration with the 4C’s as the final outcome. These participants believed that an arts-based project had opened up their minds and outlook beyond school exams.