bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Thyroid Gland Problems with Shear Wave Elastography in
Children with Celiac Disease
Authors: Basaran Meryem Keceli , Gurkan Okan 
Published: March 2022

Background:
The rate of autoimmune thyroiditis in children with celiac disease (CD) is
high relative to the normal population. Since the majority of these patients are also euthyroid, thyroid
imaging methods are gaining significance in diagnosis and follow-up. This study examines the effectiveness
of thyroid ultrasonography (US) and thyroid shear wave elastography (SWE) in diagnosing
thyroid disease in children with CD.

Materials and methods:
This cross-sectional controlled study analyzed thyroid US, SWE, serum thyroid
function tests, and thyroid autoimmune antibodies of 106 CD patients and 103 control patients
without CD. An Aplio 500 ultrasound device with a linear array transducer and elastography software
was used for thyroid US and SWE measurement of all patients.

Results:
Right lobe thyroid volume, left lobe thyroid volume, total thyroid volume, thyroid mean elasticity
(m/s), right lobe elasticity (kPa), left lobe elasticity (kPa), and mean thyroid elasticity (kPa) levels
of the CD group were higher than those of the control group (p < 0.001). The relationships between
thyroid US and thyroid mean elasticity (m/s), thyroid mean elasticity (kPa), anti-thyroid peroxidase
antibody, and thyroid-stimulating hormone were positive and moderate, respectively (r = 0.612, 0.612,
0.636, and 0.565, respectively; p < 0.001).

Conclusion:
In this study, SWE findings were compatible with laboratory findings, as they constituted
a sensitive and useful method in the diagnosis and follow-up of autoimmune thyroid disease in children
with CD.
Clozapine in a Young Female with Drug-Resistant Schizophrenia: A Case
Report of Development of Serositis
Authors: Aguglia Andrea , Parisi Valentina Maria , Arduino Gabriele , Amerio Andrea , Costanza Alessandra , Serafini Gianluca , Amore Mario 
Published: March 2022

Background:
Clozapine may be considered the first-line option for treatment-resistant
schizophrenia (TRS), a condition that occurs in more than 30% of patients with schizophrenia. Despite
its efficacy for treating TRS, clozapine use is limited by the occurrence of several adverse effects in
more than 70% of cases. Clozapine does not typically affect lung function, although a few cases have
been reported in the literature.

Case Presentation:
To gain a better understanding of this rare event, here we report the case study of a
young female with TRS, who was treated with clozapine and developed medium and bilateral pleural
effusion relief with contiguous atelectasis and polyserositis. Two weeks after stopping clozapine, the
follow-up chest scan showed complete remission of the pulmonary condition. We postulate that
clozapine might have caused, in this case, a specific immunoinflammatory response leading to serosal
complications.

Conclusion:
Although the underlying mechanisms of this adverse effect are not completely understood,
early manifestations, such as benign eosinophilia, fever, and flu-like symptoms need to be considered
a potential warning to facilitate an early diagnosis and carefully manage pulmonary complications
related to clozapine treatment.
Internet of Vehicles Employing Network as a Service
Authors: Kumar Pranjul , Kaur Sanmukh 
Published: March 2022

Background:
Vehicular Ad Hoc Networks (VANETs) are built on the principles of Mobile Ad-hoc networks, and there are numerous approaches to achieve vehicular communication like vehicle to infrastructure or by vehicle to vehicle with the advantage of Ad-hoc networks. In VANETs, the vehicle to itself and vehicle to roadside architecture both coexist to lend safety, services, and navigation; therefore they are an integral element of the intelligent transportation systems framework. The routing protocols in vehicle-to-vehicle communication are used to optimize the propagation of the messages.

Objective:
The purpose of this study is to analyze the traits of the routing protocols on the basis of various performance metrics like end-to-end delay, packet drop ratio, and throughput. The routing protocols named Ad-Hoc on-demand Distance Vector (AODV), Dynamic Source Routing (DSR), and Destination Sequenced Distance Vector (DSDV) have been compared considering a real-life scenario.

Objective:
The purpose of this study is to analyze the traits of the routing protocols on the basis of various performance metrics like end-to-end delay, packet drop ratio, and throughput. The routing protocols named Ad-Hoc on-demand Distance Vector (AODV), Dynamic Source Routing (DSR), and Destination Sequenced Distance Vector (DSDV) have been compared considering a real-life scenario.

Methods:
It evaluates DSDV, DSR & AODV protocols in Simulation of Urban Mobility (SUMO) through the open street map. SUMO mobility file was configured to the Network Simulator 3 to study the performance of AODV, DSDV, and DSR.

Results and Conclusion:
By examining the protocols, we concluded that AODV is better when evaluated on the parameters named end-to-end delay, packet drop ratio, and throughput. The practical application of our study can be found in collision alert, emergency response community, highway/rail collision avoidance, etc.
Effects of Optimization on User-based Charging/Discharging Control
Strategy
Authors: Wang Yang , Khan Zohaib 
Published: March 2022

Abstract:
With the increase in the number of Electric Vehicles (EVs), more power will be needed
from the grid. An increase in the load demand, losses, and grid operational costs will occur. Furthermore,
with the increasing number of EVs, there comes a possibility of user dissatisfaction which
can further lower the popularity of EVs.

Objective:
This article focuses on EV battery charging and discharging control optimization, i.e.,
optimizing load demand to minimize power grid system losses and reduce charging costs. It also
aids in the vehicle to grid (V2G) process while considering the "User Decision Variable" for each
prospective EV.

Methods:
As a load minimization problem, the optimal power flow model has been formulated first,
then the problem has been formulated for each EV. The operational cost of the charging station is an
objective function.

Results:
Further investigation of the load minimization of the IEEE33-bus system has been carried
out, and Particle Swarm Optimization (PSO) algorithm is proposed.

Conclusion:
MATLAB results show that the proposed strategy to charge and discharge can decrease
losses from the power grid, reduce the running operational cost while considering battery life
and the user's sense of security.
Pengaruh adversity quotient dan task commitment terhadap kemampuan pemecahan masalah matematika
Authors: Kartika Rina Wiji , Megawanti Priarti , Hakim Arif Rahman 
Published: March 2022

Penelitian ini bertujuan untuk mendeskripikan: (1) pengaruh adversity quotient dan task commitment secara bersama-sama terhadap kemampuan pemecahan masalah matematika; (2) pengaruh adversity quotient terhadap kemampuan pemecahan masalah matematika; dan (3) pengaruh task commitment terhadap kemampuan pemecahan masalah matematika. Metode penelitian adalah survei korelasional dengan teknik analisis regresi ganda. Sampel penelitian terdiri dari 83 siswa SMK di Jakarta Selatan yang diambil dengan teknik simple random sampling. Instrumen untuk mengukur adversity quotient dan task commitment menggunakan angket tertutup, sementara kemampuan pemecahan masalah matematika diukur dengan tes uraian. Hasil penelitian menunjukkan bahwa: (1) terdapat pengaruh positif signifikan adversity quotient dan task commitment secara bersama-sama terhadap kemampuan pemecahan masalah matematika dengan kontribusi sebesar 12,3%; (2) terdapat pengaruh positif signifikan adversity quotient terhadap kemampuan pemecahan masalah matematika dengan kontribusi sebesar 5%; dan (3) terdapat pengaruh positif signifikan task commitment terhadap kemampuan pemecahan masalah matematika dengan kontribusi sebesar 7,3%.AbstractThis research aims to reveal: (1) the effect of adversity quotient and task commitment on mathematical problem solving abilities, (2) the effect of adversity quotient on mathematical problem solving abilities, and (3) the effect of task commitment on mathematical problem solving abilities. This research was a correlational survey with multiple regression analysis technique. The sample was 83 students of three state vocational high schools in South Jakarta, Indonesia, established using the random sampling technique. The instrument to measure independent variables (adversity quotient and task commitment) is a closed questionnaire and that to measure the dependent variable (the mathematical problem solving abilities) is a mathematics description test. The results show that: (1) there is a positive effect of adversity quotient and task commitment together on mathematical problem solving ability, with a contribution of 12.3%; (2) there is a positive effect of adversity quotient on mathematical problem solving abilities, with a contribution of 5%; (3) there is a positive effect of task commitment on the mathematical problem solving abilities, with a contribution of 7.3%.
Designing Formulae for Ranking Search Results: Mixed Methods Evaluation Study
Authors: Douze Laura , Pelayo Sylvia , Messaadi Nassir , Grosjean Julien , Kerdelhué Gaétan , Marcilly Romaric 
Published: March 2022

Background
A major factor in the success of any search engine is the relevance of the search results; a tool should sort the search results to present the most relevant documents first. Assessing the performance of the ranking formula is an important part of search engine evaluation. However, the methods currently used to evaluate ranking formulae mainly collect quantitative data and do not gather qualitative data, which help to understand what needs to be improved to tailor the formulae to their end users.

Objective
This study aims to evaluate 2 different parameter settings of the ranking formula of LiSSa (the French acronym for scientific literature in health care; Department of Medical Informatics and Information), a tool that provides access to health scientific literature in French, to adapt the formula to the needs of the end users.

Methods
To collect quantitative and qualitative data, user tests were carried out with representative end users of LiSSa: 10 general practitioners and 10 registrars. Participants first assessed the relevance of the search results and then rated the ranking criteria used in the 2 formulae. Verbalizations were analyzed to characterize each criterion.

Results
A formula that prioritized articles representing a consensus in the field was preferred. When users assess an article’s relevance, they judge its topic, methods, and value in clinical practice.

Conclusions
Following the evaluation, several improvements were implemented to give more weight to articles that match the search topic and to downgrade articles that have less informative or scientific value for the reader. Applying a qualitative methodology generates valuable user inputs to improve the ranking formula and move toward a highly usable search engine.
The Opportunities and Challenges of Digital Anatomy for Medical Sciences: Narrative Review
Authors: Wickramasinghe Nilmini , Thompson Bruce R , Xiao Junhua 
Published: March 2022

Background
Anatomy has been the cornerstone of medical education for centuries. However, given the advances in the Internet of Things, this landscape has been augmented in the past decade, shifting toward a greater focus on adopting digital technologies. Digital anatomy is emerging as a new discipline that represents an opportunity to embrace advances in digital health technologies and apply them to the domain of modern medical sciences. Notably, the use of augmented or mixed and virtual reality as well as mobile and platforms and 3D printing in modern anatomy has dramatically increased in the last 5 years.

Objective
This review aims to outline the emerging area of digital anatomy and summarize opportunities and challenges for incorporating digital anatomy in medical science education and practices.

Methods
Literature searches were performed using the PubMed, Embase, and MEDLINE bibliographic databases for research articles published between January 2005 and June 2021 (inclusive). Out of the 4650 articles, 651 (14%) were advanced to full-text screening and 77 (1.7%) were eligible for inclusion in the narrative review. We performed a Strength, Weakness, Opportunity, and Threat (SWOT) analysis to evaluate the role that digital anatomy plays in both the learning and teaching of medicine and health sciences as well as its practice.

Results
Digital anatomy has not only revolutionized undergraduate anatomy education via 3D reconstruction of the human body but is shifting the paradigm of pre- and vocational training for medical professionals via digital simulation, advancing health care. Importantly, it was noted that digital anatomy not only benefits in situ real time clinical practice but also has many advantages for learning and teaching clinicians at multiple levels. Using the SWOT analysis, we described strengths and opportunities that together serve to underscore the benefits of embracing digital anatomy, in particular the areas for collaboration and medical advances. The SWOT analysis also identified a few weaknesses associated with digital anatomy, which are primarily related to the fact that the current reach and range of applications for digital anatomy are very limited owing to its nascent nature. Furthermore, threats are limited to technical aspects such as hardware and software issues.

Conclusions
This review highlights the advances in digital health and Health 4.0 in key areas of digital anatomy analytics. The continuous evolution of digital technologies will increase their ability to reinforce anatomy knowledge and advance clinical practice. However, digital anatomy education should not be viewed as a simple technical conversion and needs an explicit pedagogical framework. This review will be a valuable asset for educators and researchers to incorporate digital anatomy into the learning and teaching of medical sciences and their practice.
El vector tecnológico en las universidades públicas de la Argentina: respuestas locales a desafíos globales (2003-2020)
Authors: González Giselle 
Published: March 2022

Diversas transformaciones sociopolíticas de orden global plantean cambios en las relaciones entre Estado-educación y orden social, siendo los discursos, políticas y prácticas reguladores específicos de estas relaciones. Por un lado, se evidencia el avance de Estados competitivos conectados a una economía global, pero a la vez, emergen nuevas territorialidades que demandan saberes especializados, inclusión, y empoderamiento social. La universidad es una institución dentro de estas relaciones. Desde el surgimiento de los Estados modernos, asume un “lugar de poder” singular en la construcción del orden social que conserva hasta hoy en la trama territorial. En la Argentina, este juego de influencias asume particularidades. Específicamente, las últimas dos décadas, la iniciativa estatal crea incentivos de cambio tecnológico con base en una tradición de regionalización universitaria. Esto benefició su poder de implementación en tanto agente de cambio territorial. Desde un análisis descriptivo, que integra fuentes primarias y secundarias, el artículo examina de qué manera se implementan las políticas tecnológicas, prestando especial atención al rol que juegan los actores universitarios y al modo en que instituyen sus prácticas en la trama territorial. Para identificar el proceso de cambio se construyeron indicadores cuali-cuantitativos. El artículo contribuye a la comprensión de los tipos de cambio universitario en esquemas de subsidio público-estatal pleno.
Peran Gelombang Korea (Korean Wave) Terhadap Creative Business Masyarakat di Provinsi Jawa Timur
Authors: Lazzuarda Shofwaties Anissa 
Published: March 2022

This study aims to find out the Role of the Korean Wave (Korean Wave) To Creative Business Community in East Java Province, and find out the formation of Creative Business from the influence of the Korean Wave (Korean Wave). This research was conducted on several creative business communities in East Java Province with a total sample of 31 respondents of creative businessmen based on purposive sampling techniques. The object in this study is a creative business formed from Korean waves such as K-POP (Korean Music), K-Fashion (Korean Fashion), and K-Food (Korean Food). Data collection in this study was collected through observation and interview with several stages of data analysis such as data collection, data reduction, presentation of data, and withdrawal of conclusions. The results of this study concluded that the existence of the Korean Wave plays a role in creative business in East Java Province. This role has been the reason for the formation of various creative businesses.
Telemedicina para seguimiento de pacientes trasplantados renales durante la pandemia por COVID-19
Authors: Garcia-Lopez Andrea , Patino-Jaramillo Nasly , Sanchez-Avila Yenifer , Giron-Luque Fernando 
Published: March 2022

Introducción: La pandemia por COVID-19 generó la reestructuración de los servicios de salud en el mundo. La teleconsulta ofrece el acceso a la atención en salud a distancia como estrategia de mitigación a la propagación del virus y como una forma flexible de telemedicina.
Objetivo: Describir los resultados de atención en salud por modalidad de teleconsulta en pacientes trasplantados durante la pandemia por COVID-19.
Materiales y métodos: Estudio descriptivo de corte transversal que describe la experiencia del uso de la teleconsulta durante la pandemia por COVID-19 en un centro de trasplante de órganos en Colombia. La información fue obtenida mediante la recolección directa de la atención en el mes de abril de 2020 y a través del envío de un cuestionario electrónico estructurado para los pacientes atendidos por teleconsulta.
Resultados y discusión: Un total de 1139 pacientes con trasplante renal fueron valorados en la modalidad de teleconsulta. Alrededor de 50% de los pacientes atendidos vivían fuera de áreas metropolitanas (n=564,). Un total de 292 (de 800 contactados) respondieron la encuesta enviada con una media de edad de 48 años. Los pacientes presentaron altos porcentajes de satisfacción con el modelo de teleconsulta (n=278, 94%). Se presentaron 2 casos sospechosos de COVID-19, los cuales fueron negativos al realizar la prueba de PCR-RT.
Conclusión: La teleconsulta es una herramienta útil en la mitigación de la emergencia sanitaria, con un alto potencial, que genera mayor acceso y oportunidad de atención en salud, presentando altos índices de aceptación.
Comparative study on physiochemical and flow properties of Chickpea and Maize starch
Authors: Wadher Kamlesh , Gaurkar Sneha , Gotephode Santosh , Upadhyay Samiksha , Umekar Milind 
Published: March 2022

Excipients are generally materials other than the active ingredients basically required in the manufacturing of all types of pharmaceutical formulations. Recent years witnessed the increase in the number of researchers carrying out on the excipients derived from naturl sources such as, polysaccharides and conclued that natural excipients are comparable and could be alternative to the synthetic addditives. However, choosing the optimum excipients requires striking a balance between time and cost savings, as well as expected product performance. Starch is considered to be one of the most commonly used excipients for pharmaceutical preparations. Non-conventional starch sources have been studied profoundly in recent years for searching new additive properties. Chickpea (Cicer arietinum L.) is the largest produced food legume in globally. The objective of the present study was to compare the physiochemical and flow characteristics of starches from chick pea and maize. Starch was isolated and evaluated its physical, chemical and functional properties. Solubility of both chickpea and maize starches was increased with increasing temperatures. The Pre-compression tests such as angle of repose, bulk density, tapped density, Hausner’s ratio, and % compressibility of starch were carried out which showed that Chick pea starch powder is non-free flowing and has a low interparticulate friction.
Keywords: Excipients, Chickpea starch, Maize starch, Flow properties, Physiochemical properties.
Vaccinology: Design, Development and Approvals
Authors: Aziz-Andersen Kaiser Jay 
Published: March 2022

The goal of vaccine design and development is to manufacture and consistently produce a vaccine that is safe and effective. The vaccine discovery starts with design input in terms of identification of etiologic agent, immunogenicity, adjuvant, basic scientific concepts, non-clinical and clinical studies, and finally vaccine licensure (FDA approvals). The administering regimens are studied in clinical research laboratory and study materials are tested in suitable bench testing and biological models projecting vaccine candidate’s prophylactic immune response that is safe and effective. The vaccine manufacturing process requires critical quality control points (CQCPs) monitoring in order to maintain the steriochemical and immunological characteristics of the vaccine molecules and enable production of the vaccine in increasingly dosage quantities for ultimate human use. These aspects of vaccine development are well integrated into the total vaccinology life cycle (TVLC) regulatory requirements. The ultimate regulatory safety and efficacy requirements of the vaccine are proven through phases of clinical trials (class I, II, and III studies). The final process for human use to produce safe vaccine is part of pivotal clinical trials and data under the US FDA’s premarket approval process for full-scale production and availability of safe vaccines for clinical use.
Keywords: vaccine design and development, etiologic agent, immunogenicity
Changes in Quality Characteristics of Crassostrea gigas Oysters during Hypothermic Storage
Authors: Falko Oksana V. , Yevlash Viktoria V. , Piliugina Inna S. , Gazzavi-Rogozina Liudmylа V. , Chizhevskiy Viktor V. 
Published: March 2022

Now oysters are one of the most common representatives of aquaculture grown worldwide. Finding reliable ways to assess the quality of oysters is an important task for breeding professionals and users of these products. The Food and Agriculture Organization considers microbiological testing and organoleptic parameters as mandatory tests for evaluation of the mollusks’ safety. We believe these parameters in oysters are insufficient for unbiased evaluation of the condition of mollusks. In this research, we attempted to determine the most sensitive indices of oysters’ viability during hypothermic storage under anoxia conditions. We investigated the oysters during 6 days of their storage in a household refrigerator at a temperature of 5°C. According to microbiological studies, during the experiment, we expected a rise in the total number of microorganisms. However, there was a paradoxical situation when at the end of the observations the total number of microorganisms decreased significantly, which contradicted the negative assessment of the state of oysters by organoleptic parameters. Flow cytometry studies also showed no correlation between the percentages of necrotized and apoptotic cells to organoleptic parameters. Studies have shown that on day 3 of storage, the oysters demonstrated a partial deterioration in organoleptic characteristics, which is clearly reflected in the content of volatile basic nitrogen in the tissues of mollusks, which characterizes the protein breakdown and accumulation of toxic nitrogen compounds. Thus, the content of volatile basic nitrogen in the tissues of oysters is the most sensitive and significant parameter in terms of biosafety of mollusks.
Keywords: hypothermic storage, oysters, microbial flora, food quality, nitrogen