bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metformin: A Promising Antidiabetic Medication for Cancer Treatment
Authors: Mu Wei , Jiang Yunyun , Liang Guoqiang , Feng Yue , Qu Falin 
Published: November 2022

Abstract:
Metformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin in-hibits hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent years, several studies have shown that metformin is a potential therapeutic agent against cancer, alone or combined with other anticancer treatments. Metformin mainly activates the AMPK com-plex and regulates intracellular energy status, inhibiting the mitochondrial respiratory chain com-plex I and reducing the production of reactive oxygen species. Other anticancer targets of metfor-min are specific transcription factors inhibiting cell proliferation, promoting apoptosis and reducing drug resistance. In addition, metformin modulates tumor cells' response to anticancer treatments, favoring the activity of T cells. In diabetic patients, metformin reduces the occurrence of cancer and improves the prognosis and efficacy of anticancer treatments. In this review, we provided a com-prehensive perspective of metformin as an anticancer drug.
Direct SARS-CoV-2 Detection System Utilizing Simple-to-Use
Capillary Gel Electrophoresis Sample-to-Result
Authors: Yang Neo , Kuo Meya , Liu Jerry , Amirkhanian Varoujan , Tsai Eric 
Published: November 2022

Aim:
We present a Direct SARS-CoV-2 Detection System that achieves
sample-to-results in less than two hours in three simple steps.

Methods:
The Detection System includes Direct one-step Reverse Transcription PCR
(RT-PCR) reagents (Qexp-MDx kit), a portable
thermal cycler (Qampmini) with a preprogrammed
chip and a simple-to-use Capillary Gel Electrophoresis system (Qsep
Series Bio-Fragment Analyzer) with high fluorescence detection sensitivity to solve the
problems associated with traditional real-time PCR (qPCR) systems which produces
high false positive results.

Results:
The proposed simple-to-use detection platform can provide high detection
sensitivity (identify less than 20 copies) and fast results (less than 120 minutes), which
would be suitable for field testing applications.

Conclusion:
Our high detection sensitivity platform provides fast and accurate results
in 120 minutes without doing DNA/RNA extraction.
Hydroxycoumarins and some Flavonoids from Pistacia atlantica Desf. as Multi-targets Inhibitors for Alzheimer’s Disease: Molecular Docking and ADMET Studies
Authors: Lamrani Meriem , Serseg Talia , Benarous Khedidja , Sifi Ibrahim , Yousfi Mohamed 
Published: November 2022

Objective:The present study aimed to identify new selective inhibitors for acetylcholinesterase, butyrylcholinesterase, monoacylglycerol lipase, beta-secretase, and Asparagine endopeptidase, the targets enzymes in Alzheimer’s disease.Methods:The inhibitory effect of P. atlantica Desf. methanol extracts against AChE were determined using Ellman’s method. The molecular docking study is achieved using Autodock Vina. The structures of the molecules 3-methoxycarpachromene, masticadienonic acid, 7-ethoxycoumarin, 3′,5,7- trihydroxy-4′-methoxyflavanone and 5,6,7,4′-tetrahydroxyflavonol-3-O-rutinoside and the five enzymes were obtained from the PubChem database and Protein databank. ADMET parameters were checked to confirm their pharmacokinetics using swiss-ADME and ADMET-SAR servers.Results:P. atlantica Desf. methanol extracts showed a notable inhibitory effect against AChE (IC50 = 0.26 ± 0.004 mg/ml). The molecular docking results of 3-methoxycarpachromene, masticadienonic acid, 7-ethoxycoumarin, 3′,5,7-trihydroxy-4′-methoxyflavanone and 5,6,7,4′-tetrahydroxyflavonol-3-Orutinoside with the five enzymes show significant affinities of these molecules towards Alzheimer disease targets, where they could form several interactions, such as hydrogen bonds and hydrophobic interactions with the studied enzymes. The shortest hydrogen bond is 1.7 A° between masticadienonic acid and Arg128 of the active site of BACE, while the lowest free energy is -11.2 of the complex 5,6,7,4′-tetrahydroxyflavonol-3-O-rutinoside –HuBchE. To the best of our knowledge, these molecules' potential anti-Alzheimer disease effect is studied in this paper for the first time.Conclusion:The docking studies of this work show that 3-methoxycarpachromene and masticadienonic acid, 7-ethoxycoumarin, 3′,5,7-Trihydroxy-4′-methoxyflavanone and 5,6,7,4′-tetrahydroxyflavonol- 3-O-rutinoside have good affinities towards the enzymes involved in Alzheimer pathology, which confirm the ability of these molecules to inhibit the studied enzymes namely: HuAChE, HuBChE, BACE, MAGL, and AEP. These molecules might become drug candidates to prevent Alzheimer's disease.
How to Choose Suitable Reference Electrode and Aqueous Electrolyte to
Avoid Error in Electrochemical Measurements?
Authors: Wang Hui , Wang Min , Wang Jingjing 
Published: November 2022

Objective:
To reduce the experimental error, three commonly used reference electrodes
(Hg/HgO, Hg/Hg2Cl2 (SCE), and Ag/AgCl) are investigated to select the appropriate electrode in
different aqueous electrolytes.

Methods:
Besides, the correct electrochemical test method is proposed according to the stability of
the reference electrode. After measuring the potential difference of reference electrode in various
aqueous electrolytes, it is found that Hg/HgO electrode is suitable for alkaline electrolytes, with
minimum deviation in 6 M KOH solution, SCE should be used in acidic electrolytes, with minimum
deviation in H2SO4 solution less than 1 M, and both SCE and Ag/AgCl electrode can be used in neutral
electrolytes.

Results:
Due to the liquid junction potential, the result of using the double salt bridge is more accurate
than that of using the single salt bridge.

Conclusion:
The stability of various reference electrodes in electrolytes is discrepant. Therefore,
calibration is emphasized since the potential of the reference electrode drifts and even becomes invalid
after prolonged use.
Sandwich Enzyme-linked Immunosorbent Assay (ELISA) to Quantify
Monoclonal Antibody (B[a]P-13) for Herbal Medicine Products
Authors: Shin Han-Seung , Kim Yong-Yeon 
Published: November 2022

Abstract:
Sandwich enzyme-linked immunosorbent assay (ELISA) to quantify monoclonal antibody (B[a]P-13)

Background:
Only a few studies have focused on the analysis using specific antibodies in the sandwich ELISA method to each B[a]P in herbal medicine products. In contrast to the sandwich ELISA method, many competitive ELISA methods using specific antibodies such as benzo[a]pyrene monoclonal antibody (B[a]P-13) and a goat anti-mouse IgG (H+L) cross-adsorbed secondary antibody, horseradish peroxidase (HRP) were developed.

Introduction:
The objective of this study was to develop and validate the method for the response of the benzo[a]pyrene monoclonal antibody (B[a]P-13) and goat anti-mouse IgG (H+L) cross-adsorbed secondary antibody (HRP) to prepare the immunogen and its application to detect the benzo[a]pyrene in various herbal medicine products.

Methods:
This research method includes preparation of B[a]P-protein conjugates, sampling and extraction procedure for herbal medicines, sandwich ELISA procedure, evaluation of cross-reactivity for determination, matrix effect of the organic solvents, correlation of benzo[a]pyrene detection ELISA compared to HPLC-FLD in herbal medicine products.

Results:
The sandwich ELISA method for B[a]P was validated in linearity (R2 > 0.99), the limit of detection (LOD) (0.080.19 μg/kg) and limit of quantification (LOQ) (0.240.57 μg/kg), accuracy (95.58117.06 %), and precision (3.8010.26 %). The cross-reactivity (CR) was found for B[a]P (100%), CHR (39%), B[b]F (27%), and B[a]A (41%). As a solvent, acetonitrile (MeCN) was used to express the normalized sandwich ELISA calibration curves with benzo[a]pyrene monoclonal antibody (B[a]P-13). The antigen-antibody binding in sandwich ELISA was decreased about 10 times with increasing the salt content (0.0060.18 mol/L phosphate to 20400 mmol/L). The pH range from 6 to 9 was not considered to affect the performance of the sandwich ELISA. Correlation of B[a]P detection in herbal medicines with ELISA compared to HPLC-FLD expressed good correlation (R2 = 0.991) and the slope of the graph for the ELISA (B[a]P-equivalents μg/kg) value divided by the HPLC-FLD (B[a]P μg/kg) value was 0.7292.

Conclusion:
Therefore, sandwich ELISA method using benzo[a]pyrene monoclonal antibody (B[a]P-13) could be an alternative screening method for detection of B[a]P in herbal medicine products.
PENGARUH MODEL PEMBELAJARAN ARGUMENT DRIVEN INQUIRY (ADI) TERHADAP PENINGKATAN KETERAMPILAN ARGUMENTASI DAN HASIL BELAJAR IPA
Authors: Arfiany Nursuci , Ramlawati Ramlawati , Yunus Sitti Rahma 
Published: November 2022

Penelitian ini adalah penelitian eskperimen semu yang bertujuan untuk mengetahui ada tidaknya pengaruh model pembelajaran Argument Driven Inquiry (ADI) terhadap peningkatan keterampilan argumentasi dan hasil belajar IPA peserta didik kelas VIII SMPN 29 Makassar. Populasi dalam penelitian ini adalah seluruh peserta didik kelas VIII SMPN 29 Makassar sebanyak 7 kelas berjumlah 248 orang, sedangkan sampelnya adalah kelas VIII 1 sebagai kelas eksperimen berjumlah 35 orang dan kelas VIII 2 sebagai kelas kontrol berjumlah 36 orang dengan pemilihan sampel secara purposive sampling. Hasil analisis deskriptif peningkatan keterampilan argumentasi peserta didik diperoleh skor rerata N-Gain pada kelas eksperimen 0,60 tergolong kategori sedang dan kelas kontrol 0,39 juga tergolong kategori sedang. Sedangkan peningkatan hasil belajar peserta didik diperoleh skor rerata N-Gain pada kelas eksperimen 0,46 kategori sedang dan kelas kontrol 0,37 tergolong kategori sedang. Berdasarkan hasil analisis inferensial menggunakan uji-t diperoleh kesimpulan bahwa pengujian keterampilan argumentasi hasil belajar menunjukkan ditolak dan diterima sehingga dapat disimpulkan bahwa terdapat pengaruh model pembelajaran Argument-Driven Inquiry (ADI) terhadap peningkatan keterampilan argumentasi dan hasil belajar IPA peserta didik didik kelas VIII SMPN 29 Makassar pada materi pokok zat aditif dan zat adiktif.
Pengembangan Alat Peraga 3D berbasis Eco-Friendly melalui Project Based Online Learning untuk Meningkatkan Kreativitas Ilmiah Calon Guru IPA
Authors: Erlina Nia , I Wayan Sukra Warpala  , Putu Prima Juniartina  
Published: November 2022

IPA terpadu adalah perpaduan kajian dua bidang atau lebih dari berbagai bidang Fisika-Kimia-Biologi mengenai suatu tema tertentu secara terintegrasi. Perpaduan ini mempermudah pendidik dalam pembelajaran terkait efektivitas dan efisiensi proses pembelajaran karena tidak perlu berulang kali membahas suatu tema yang serupa. Namun, beberapa kendala yang dialami peserta didik dalam pembelajaran IPA Terpadu, yaitu materi sulit untuk dipahami dan dipelajari. Solusi yang dapat ditawarkan untuk mengatasi kendala dalam pembelajaran IPA terpadu adalah menghadirkan alat peraga, berupa alat peraga 3D (berwujud tiga dimensi). Alat peraga 3D berperan sebagai alat informasi belajar karena membawa konsep materi yang akan dipelajari dan mampu mengembangkan kreativitas guru, dosen atau bahkan orang tua dalam memahami materi pelajaran. Fokus yang akan diangkat dalam penelitian ini adalah pengembangan alat peraga 3D berbasis Eco-Friendly melalui Project Based Online Learning untuk meningkatkan kreativitas ilmiah calon guru IPA. Penelitian ini merupakan R&D (research and development) dengan menggunakan model ADDIE. Penelitian ini dilaksanakan di Universitas Pendidikan Ganesha. Subjek dalam penelitian ini adalah mahasiswa, dosen, serta ahli pendidikan dan pembelajaran IPA. Teknik analisis data yang digunakan yaitu statistik deskriptif, berdasarkan hasil penilaian dari ahli (media, materi dan pembelajaran). Hasil penelitian menunjukkan perangkat yang dikembangkan mendapatkan predikat sangat valid serta dapat menumbuhkan kreativitas ilmiah mahasiswa calon guru IPA.
Pengembangan Media Pembelajaran Elektronika Analog & Digital Berbasis Trainer Pada Jurusan Teknik Elektro Fakultas Teknik Universitas Negeri Padang
Authors: Hidayat Sahip , Asnil Asnil 
Published: November 2022

Perkembangan teknologi yang sangat pesat diera globalisasi saat ini telah memberikan banyak manfaat dalam kemajuan diberbagai aspek sosial.Penggunaan teknologi oleh manusia dalam membantu menyelesaikan pekerjaan merupakan hal yang menjadi kebutuhan dalam kehidupan.Trainer adalah kumpulan komponen dan alat sebenarnya atau pun duplikasi dari pesawat yang sebenarnya yang dapat memberikan pengalaman mempraktekkan.Pengembangan trainer ini dilatar belakangi oleh minimnya trainer pendukung mata kuliah Elektronika Analog dan Digital serta penggunaan trainer Gerbang logika yang ada belum optimal dalam pembelajaran. Jenis pengembangan penelitian ini adalah penelitian dan pengembangan (Research and Development). Penelitian ini merupakan penelitian pengembangan yang menggunakan prosedur penelitian Borg and Gall. Hasil kajian diperoleh bahwa validitas Trainer sebesar 88%, Praktikalitas yang dihasilkan dengan rata-rata sebesar 86% dan Uji coba terbatas terhadap 16 orang mahasiswa Program Studi S1-Pendidikan Teknik Elektro, diperoleh persentase penilaian 92 %.Trainer Gerbang Logika dikategorikan valid dan praktis digunakan dalam praktikum.
Perancangan Alat Peraga Tornis CL Untuk Menentukan Nilai Resistor
Authors: Lastya Hari Anna , Sadrina Sadrina , Chairunnisah Chairunnisah 
Published: November 2022

Alat peraga adalah suatu alat yang dapat diserap oleh mata dan telinga dengan tujuan membantu guru agar proses belajar mengajar menjadi lebih efektif dan efisien. Perancangan dan pengembangan produk ini dilakukan peneliti untuk menciptakan suatu media pembelajaran terbaru yaitu alat peraga Tornis CL penentuan nilai resistor. Alat peraga ini berfungsi untuk mempermudah dalam pembacaan nilai gelang warna secara manual. Produk ini adalah produk terbaru yang dirancang dan diciptakan oleh peneliti yang berbeda dengan produk serupa lainnya. Media pembelajaran alat peraga Tornis CL sebagai penentuan nilai resistor ini layak digunakan berdasarkan hasil validasi dari ahli materi/konten, ahli media dan ahli desain, serta dilakukan revisi sesuai dengan saran/rekomendasi dari para ahli. Hasil validasi ahli materi/konten dinyatakan sangat valid dengan jumlah skor sebesar 47 dari nilai maksimum 50 dengan persentase 94% dan rerata skor sebesar 4,70 dengan kategori “Sangat Valid”. Serta hasil validasi ahli media dinyatakan sangat valid dengan jumlah skor sebesar 44 dengan persentase 88% dan rerata skor sebesar 4,40 dengan kategori “Sangat Valid”. Dan hasil validasi ahli desain dinyatakan valid jumlah skor sebesar 44 dengan persentase 73,33% dan rerata skor sebesar 3,67 dengan kategori “Valid”.
Pengembangan Modul Pembelajaran Berbasis TEFA pada Pembelajaran Pengelolaan Bengkel Sepeda Motor Siswa Kelas XII SMK Rokan Hulu
Authors: Nitiswito Trimo , Maksum Hasan 
Published: November 2022

Penelitian ini bertujuan untuk menghasilkan Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA yang valid, praktis dan efektif. Aspek yang akan dilihat adalah untuk mengetahui validitas, praktikalitas dan efektifitas Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA. Penelitian ini menggunakan metode penelitian dan pengembangan (Research and Development). Model pengembangan modul pembelajaran ini menggunakan model IDI (Instruksional Development Institute). Model IDI menetapkan prinsip-prinsip pendekatan sistem yang meliputi tiga tahap yaitu pendefinisian (define), pengembangan (develop) dan evaluasi (evaluate). Jenis data dalam penelitian ini adalah data primer yaitu data yang diperoleh secara langsung dari validator dosen,guru dan siswa melalui angket pengujian validitas, praktikalitas dan efektifitas Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA yang dikembangkan. Instrumen pengumpul data berbentuk angket. Teknik analisis data deskriptif untuk mendeskripsikan kevalid, praktis dan efektif Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA. Validitas Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA dilihat dari Validitas Format Modul, Validitas Materi Modul dan Validitas Penyajian Modul. Validitas Format Modul dengan nilai 0,94, Validitas Materi Modul dengan nilai 0,91 dan Validitas Penyajian Modul dengan nilai 0,925. Praktikalitas Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA dilihat dari praktikalitas guru dan siswa. Praktikalitas guru dengan nilai 96,25%, Praktikalitas siswa dengan nilai 85,17%. Efektifitas Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA dilihat dari pretest dan posttest belajar siswa yaitu pretest 54,42 dan posttest 85,00 dengan peningkatan hasil belajar sebesar 64,02%. Berdasarkan temuan penelitian ini disimpulkan bahwa Modul Pembelajaran Pengelolaan Bengkel Sepeda Motor Berbasis TEFA dilihat dari ini valid, praktis dan efektif untuk dimanfaatkan sebagai modul pembelajaran pada Mata Pelajaran Bengkel Sepeda Motor.
Bagaimana Perbandingan Penguasaan Konsep Siswa SMP dan SMA Pada Materi Listrik Arus Searah ?
Authors: Azizah Nafilah Husnaul , Kusairi Sentot 
Published: November 2022

Tujuan penelitian ini adalah untuk membandingkan penguasaan konsep siswa di dua Sekolah Menengah Pertama dan satu Sekolah Menengah Atas di Kabupaten Malang pada materi listrik arus searah. Penelitian ini menggunakan metode deskriptif kuantitatif dengan instrumen soal berupa pilihan ganda sebanyak 10 butir soal yang diadaptasi dari Determining and Interpreting Resistive Electric Circuit Concepts Test (DIRECT). Subjek penelitian terdiri dari 33 siswa SMP dan 33 siswa SMA di Kabupaten Malang. Hasil penelitian menunjukkan bahwa ada perbedaan yang signifikan antara penguasaan konsep siswa SMP dan siswa SMA dengan kategori penguasaan konsep tergolong baik untuk siswa SMP (72,72). Siswa SMA masih tergolong dalam kategori cukup (57,27). Dari hasil penelitian yang ditemukan ada beberapa kesulitan yang dialami oleh siswa pada konsep listrik arus searah yaitu kesulitan dalam mengilustrasikan konsep medan listrik pada rangkaian listrik dan kesalahan konsep mengenai arus. Penelitian ini berguna sebagai referensi untuk peneliti yang lain dalam melakukan penelitian tentang penguasaan konsep siswa sekolah menengah.
Optimisation of construction mode of residential houses based on the genetic algorithm under BIM technology
Authors: Liu Sufang , Shi Lei , Liu Simian , Wang Chuan 
Published: November 2022

Abstract
BIM technology is a breakthrough in the construction industry whose application is of great value, and the engineering design, engineering budget and cost control combined with BIM technology have been developed rapidly. Therefore, in this paper, BIM technology is adopted to optimise the construction mode, and the genetic algorithm is selected to solve the scheduling model of construction. By applying an interdisciplinary research method combined with computer science and technology, an intelligent optimisation model of construction can provide a new research perspective and technical method for the development of the construction industry.
Analysis of the Supplier Relationship Management Function and Activities
Authors: Ungureanu Cristina-Elena 
Published: November 2022

Abstract
The main purpose of this article is to give an overview on the research conducted in the area of “supplier relationship management” in the industrial engineering field. To this overview, three main areas will be addressed. First, the evolution of the “supplier relationship management” function from being a technical knowledge broker across a business unit or organisation, to acting as a facilitator for the business’ strategic decision which need to be taken primarily within the supply chain management area. Second, how to set up a supply chain management governance system and what to consider for this system, in order to optimize the relevant activities and provide the expected supplier qualitative results. And finally, review on a set of tools and techniques for the supplier relationship management area, which, if implemented and used accordingly, can generate both short- and long-term benefits for its impacted stakeholders.
A Review on Tribological Behaviour of 3D Printed Mechanical Components
Authors: Macovei Gheorghe , Paleu Viorel 
Published: November 2022

Abstract
Technologies such additive manufacturing are slowly becoming more and more present on the market, covering different areas of the industry due to its great potential. Even so, there are still many aspects which are unexplored or which can be improved. One of them being the study of the tribological proprieties for all these parts, which are produced through additive manufacturing methods, such as powder bed fusion, binder jetting, direct energy deposition, fused filament fabrication, material jetting, vat photopolymerization, and sheet lamination. The scope of this paper is to bring together the tribological proprieties for the 3D printed parts, and to have a critical analysis of these proprieties, in order to easily decide which printing method is suitable, depending of the working conditions of the printed component. In addition, this paper will describe the working principle for each technology, and the type of materials that are commonly used in the printing process. Depending of the printing method, the tribological proprieties vary greatly. For example, for the parts which are manufactured through powder bed fusion, it was found that the wear resistance is higher, and with a lower friction coefficient than for a part manufactured through traditional methods. In addition, for many printing methods, the produced part might require an additional step of treatment. This is the case with binder jetting, where infiltration and sintering are often used because the 3D-printed part is porous and weak. Some researchers found that the average friction coefficient measured for a steel-based part, treated with bronze infiltration, is comparable with the friction coefficient measured on a part made of the same material, manufactured through the direct energy deposition method. Of course, due to the physical limitations of the 3D printing method, the system will allow only the usage of a specific type or class of materials. One of such method is fused filament fabrication, where only thermoplastics are used. Along with vat photopolymerization and material jetting, these methods present comparable tribological proprieties.
A Study on the Dynamics of an AC Induction Motor Rotor Based on the Analysis of Free Response at Impulse Excitation
Authors: Bumbu Neculai Eduard , Horodincă Mihăiţă 
Published: November 2022

Abstract
This paper focuses on a topic frequently involved in the dynamics of transient phenomena on rotary machines driven by an AC induction motor supplied by a three-phase four-wire electrical system: the free response of the dynamic system mirrored in the torsional vibrations of its rotor. This dynamic system is reducible at a single degree of freedom system, equivalent of a spring-mass-damper but as a torsional vibratory system composed of the motor rotor (having a moment of inertia) the rotating magnetic field (having a torsional stiffness) and a hypothetical damper (generating a viscous damping mainly due to the air friction). This free response is useful mostly to characterize the transmissibility related to the conversion of information from mechanical to electrical power through this dynamic system. A simple computer-assisted setup is used to describe indirectly and to analyze the free response (generated when the motor is switched-on or after star to delta commutation sequence), using the active electrical power absorbed by the motor.