bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abraham, Isaac, and the toxin: a Kavkan reading of the binding of Isaac
Authors: Willard-Kyle Christopher 
Published: August 2022

AbstractI argue that the story of God's commanding Abraham to sacrifice Isaac can be read as a variant of Kavka's (1983) Toxin Puzzle. On this reading, Abraham has no reason to kill Isaac, only reason to intend to kill Isaac. On one version of the Kavkan reading, it's impossible for Abraham, thus situated, to form the intention to kill Isaac. This would make the binding an impossible story: I explore the ethical and theological consequences of reading the story in this way. Finally, I suggest that analytic philosophers may have more to contribute to interpretative projects in philosophical theology than generally practised.
On environmental justice, Part II: non-absolute equal division of rights to the natural world
Authors: Mazor Joseph 
Published: August 2022

AbstractThis article considers whether any interpretation of the idea of equal claims to the natural world can resolve the Canyon Dilemma (i.e. can justify protecting the Grand Canyon but not a small canyon from mining by a poor generation). It first considers and ultimately rejects the idea of subjecting natural resource rights to an intergenerational equal division. It then demonstrates that a pluralist theory of environmental justice committed to both respect for the separateness of persons and to the collective good can justify a type of intergenerational non-absolute equal division of natural resource rights that can navigate the Canyon Dilemma.
A complicated Glenn procedure: risk factors and association with adverse long-term neurodevelopmental and functional outcomes
Authors: Khaira Gurpreet K. , Joffe Ari R. , Guerra Gonzalo G. , Matenchuk Brittany A. , Dinu Irina , Bond Gwen , Alaklabi M. , Robertson Charlene M.T. , Sivarajan V. Ben ,   for the Complex Pediatric Therapies Follow-up Program
Published: August 2022

AbstractObjectives:To determine potentially modifiable risk factors for a complicated Glenn procedure (cGP) and whether a cGP predicted adverse neurodevelopmental and functional outcomes. A cGP was defined as post-operative death, heart transplant, extracorporeal life support, Glenn takedown, or prolonged ventilation.Methods:All 169 patients having a Glenn procedure from 2012 to 2017 were included. Neurodevelopmental assessments were performed at age 2 years in consenting survivors (n = 156/159 survivors). The Bayley Scales of Infant and Toddler Development-3rd Edition (Bayley-III) and the Adaptive Behavior Assessment System-2nd Edition (ABAS-II) were administered. Adaptive functional outcomes were determined by the General Adaptive Composite (GAC) score from the ABAS-II. Predictors of outcomes were determined using univariate and multiple variable linear or Cox regressions.Results:Of patients who had a Glenn procedure, 10/169 (6%) died by 2 years of age and 27/169 (16%) had a cGP. Variables statistically significantly associated with a cGP were the inotrope score on post-operative day 1 (HR 1.04, 95%CI 1.01, 1.06; p = 0.010) and use of inhaled nitric oxide post-operatively (HR 7.31, 95%CI 3.19, 16.76; p < 0.001). A cGP was independently statistically significantly associated with adverse Bayley-III Cognitive (ES −10.60, 95%CI −17.09, −4.11; p = 0.002) and Language (ES −11.43, 95%CI −19.25, −3.60; p = 0.004) scores and adverse GAC score (ES −14.89, 95%CI −22.86, −6.92; p < 0.001).Conclusions:Higher inotrope score and inhaled nitric oxide used post-operatively were associated with a cGP. A cGP was independently associated with adverse 2-year neurodevelopmental and functional outcomes. Whether early recognition and intervention for risk of a cGP can prevent adverse outcomes warrants study.
Interpretable Models Capture the Complex Relationship Between Climate Indices and Fire Season Intensity in Maritime Southeast Asia
Authors: Daniels William S. , Buchholz Rebecca R. , Worden Helen M. , Ahamad Fatimah , Hammerling Dorit M. 
Published: August 2022

AbstractThere have been many extreme fire seasons in Maritime Southeast Asia (MSEA) over the last two decades. Fires, in turn, are a major driver of atmospheric carbon monoxide (CO) variability, especially in the Southern Hemisphere. Here we attempt to maximize the amount of CO variability that can be explained during fire season in MSEA (defined as September through December) via human‐interpretable statistical models that use only climate mode indices as predictor variables and are trained on data from 2001 to 2019. We expand upon previous work through the complexity at which we study the connections between climate mode indices and atmospheric CO (an indicator of fire intensity). Specifically, we present three modeling advancements. First, we analyze five different climate modes at a weekly timescale, increasing explained variability by 15% over models a monthly timescale. Second, we accommodate multiple lead times for each climate mode index, finding that some indices have very different effects on CO at different lead times. Finally, we model the interactions between climate mode indices at a weekly timescale, providing a framework for studying more complex interactions than previous work. Furthermore, we perform a stability analysis and show that our model for the MSEA region is robust, adding weight to the scientific interpretation of selected model terms. We believe the relationships quantified here provide new understanding of a significant mode of variability in MSEA, specific lead times for use in forecasts, and a method for evaluating climate mode‐CO relationships in climate model output.
Strong absorption and ultrafast localisation in NaBiS2 nanocrystals with slow charge-carrier recombination
Authors: Huang Yi-Teng , Kavanagh Seán R. , Righetto Marcello , Rusu Marin , Levine Igal , Unold Thomas , Zelewski Szymon J. , Sneyd Alexander J. , Zhang Kaiwen , Dai Linjie , Britton Andrew J. , Ye Junzhi , Julin Jaakko , Napari Mari , Zhang Zhilong , Xiao James , Laitinen Mikko , Torrente-Murciano Laura , Stranks Samuel D. , Rao Akshay , Herz Laura M. , Scanlon David O. , Walsh Aron , Hoye Robert L. Z. 
Published: August 2022

AbstractI-V-VI2 ternary chalcogenides are gaining attention as earth-abundant, nontoxic, and air-stable absorbers for photovoltaic applications. However, the semiconductors explored thus far have slowly-rising absorption onsets, and their charge-carrier transport is not well understood yet. Herein, we investigate cation-disordered NaBiS2 nanocrystals, which have a steep absorption onset, with absorption coefficients reaching >105 cm−1 just above its pseudo-direct bandgap of 1.4 eV. Surprisingly, we also observe an ultrafast (picosecond-time scale) photoconductivity decay and long-lived charge-carrier population persisting for over one microsecond in NaBiS2 nanocrystals. These unusual features arise because of the localised, non-bonding S p character of the upper valence band, which leads to a high density of electronic states at the band edges, ultrafast localisation of spatially-separated electrons and holes, as well as the slow decay of trapped holes. This work reveals the critical role of cation disorder in these systems on both absorption characteristics and charge-carrier kinetics.
Electron-mediated control of nanoporosity for targeted molecular separation in carbon membranes
Authors: Oh Banseok , Seo Hyeokjun , Choi Jihoon , Lee Sunggyu , Koh Dong-Yeun 
Published: August 2022

AbstractCarbon molecular sieve (CMS) membranes are considered game-changers to overcome the challenges that conventional polymeric membranes face. However, CMS membranes also confront a challenge in successfully separating extremely similar-sized molecules. In this article, high-precision tuning of the microstructure of CMS membranes is proposed by controlled electron irradiation for the separation of molecules with size differences less than 0.05 nm. Fitting CMS membranes for targeted molecular separation can be accomplished by irradiation dosage control, resulting in highly-efficient C2H4/C2H6 separation for low dosages (∼250kGy, with selectivity ∼14) and ultra-selective H2/CO2 separation for high dosages (1000∼2000kGy with selectivity ∼80).The electron irradiated CMS also exhibits highly stabilized permeability and selectivity for long-term operation than the pristine CMS, which suffers from significant performance degradation due to physical aging. This study successfully demonstrates electron irradiation as a possible way to construct “designer” nanoporous carbon membranes out of the standard components mostly confined to pyrolysis conditions.
qMRI-BIDS: An extension to the brain imaging data structure for quantitative magnetic resonance imaging data
Authors: Karakuzu Agah , Appelhoff Stefan , Auer Tibor , Boudreau Mathieu , Feingold Franklin , Khan Ali R. , Lazari Alberto , Markiewicz Chris , Mulder Martijn , Phillips Christophe , Salo Taylor , Stikov Nikola , Whitaker Kirstie , de Hollander Gilles 
Published: August 2022

AbstractThe Brain Imaging Data Structure (BIDS) established community consensus on the organization of data and metadata for several neuroimaging modalities. Traditionally, BIDS had a strong focus on functional magnetic resonance imaging (MRI) datasets and lacked guidance on how to store multimodal structural MRI datasets. Here, we present and describe the BIDS Extension Proposal 001 (BEP001), which adds a range of quantitative MRI (qMRI) applications to the BIDS. In general, the aim of qMRI is to characterize brain microstructure by quantifying the physical MR parameters of the tissue via computational, biophysical models. By proposing this new standard, we envision standardization of qMRI through multicenter dissemination of interoperable datasets. This way, BIDS can act as a catalyst of convergence between qMRI methods development and application-driven neuroimaging studies that can help develop quantitative biomarkers for neural tissue characterization. In conclusion, this BIDS extension offers a common ground for developers to exchange novel imaging data and tools, reducing the entrance barrier for qMRI in the field of neuroimaging.
Testosterone deficiency and metabolic disturbances in men who fathered a child by use of donated spermatozoa
Authors: Elenkov Angel , Zarén Peter , Sundell Bianca , Lundin Lovisa , Giwercman Aleksander 
Published: August 2022

AbstractDose–response association between level of impairment of semen quality and risk of morbidity or premature death has been reported. Therefore, it can be presumed that men utilizing donated spermatozoa, i.e. patients with non-obstructive azoospermia, are at highest risk for adverse health outcomes. To evaluate the risks of prescription of medications for common metabolic disturbances and testosterone replacement therapy (TRT) among men who father children with donated spermatozoa—who presumably do it due to severe impairment of fertility. We used Swedish nationwide register data on all fathers who had a live-born child between 2007 and 2014 in order to compare men who fathered children with donated spermatozoa to the ones who became fathers by using own gametes. Cox regression analysis was used in order to estimate the post-conception incidence of prescription of medicines for hypertension (HT), diabetes (type 1 and 2), dyslipidaemia (DLE) or TRT. Starting the follow up at time of conception, models were adjusted for age, educational level, and previous cancer treatment. In total 410,119 childbirths were included in the analysis. Among them, for 390 fathers donated spermatozoa were utilized. Fathers to children conceived with donated spermatozoa had higher risk for having TRT prescribed (HR: 18.14; 95%CI: 11.71–28.10; p ≪ 0.001). Same was true for DLE (HR: 2.08; 95%CI: 1.27–3.39; p = 0.003) but not diabetes. Fathers to children conceived by use of donated spermatozoa are at significantly increased risk for testosterone treatment and dyslipidaemia, necessitating stringent follow up and inclusion in prevention programs.
Frozen section utilization to omit systematic biopsy in diagnosing high risk prostate cancer
Authors: Tae Jong Hyun , Jin Hyun Jung , Noh Tae Il , Shim Ji Sung , Kang Seok Ho , Cheon Jun , Lee Jeong Gu , Kang Sung Gu 
Published: August 2022

AbstractThe current guidelines for targeted prostate biopsy recommend an additional systematic biopsy regardless of clinical risk assessment.
To evaluate frozen section biopsy utilization in targeted prostate biopsy to omit systematic biopsies in cases of positive frozen section results of patients with clinical features suggestive of high-risk prostate cancer. In this prospective, single-center study, we enrolled patients with a Prostate Imaging-Reporting and Data System (PI-RADS) 5 lesion on magnetic resonance imaging (MRI) with clinical evidence suggestive of high-risk prostate cancer (either an extracapsular extension or prostate-specific antigen level > 20 ng/ml). All patients underwent 2–4 core targeted biopsies utilizing frozen section biopsy with immediate results, allowing patients with a positive result to omit a systematic biopsy. In case of a negative result, additional systematic biopsies were performed. The primary endpoint was the detection rate of targeted biopsy. Patient demographics, clinical variables were analyzed using SPSS version 20. Sixty-six patients were enrolled in this study. Among them, 63 patients were diagnosed with cancer without the need for an additional systematic biopsy. Three patients were non-diagnostic with target biopsy alone. Hence an additional systematic biopsy was performed. Two of these patients were diagnosed with prostate cancer and one tested negative for cancer. In this report we looked into the necessity of taking a routine systematic biopsy in patients with high risk features of prostate cancer. We found that utilizing frozen section biopsy for targeted biopsy reduces unneccessary systematic biopsy in 97% of cases and still provides a means for systematic biopsy when targeted biopsy alone fails to make the diagnosis.
Association Between Early Speech-Language Pathology Consultation and Pneumonia After Cardiac Surgery
Authors: Kumble Sowmya , Strickland Amber , Cole Therese K. , Canner Joseph K. , Frost Nicole , Madeira Tim , Alejo Diane , Steele Anne , Schena Stefano 
Published: August 2022

Purpose:
Patients undergoing cardiac surgery are reported to be at higher risk for oropharyngeal dysphagia and aspiration, which may predispose them to respiratory complications such as pneumonia. Speech-language pathology consultation facilitates early identification of swallowing difficulties providing appropriate and timely interventions during the postoperative period. This study explores the association between pneumonia and timing of speech-language pathology order entry and evaluation following cardiac surgery.

Method:
A retrospective study was performed on adults who underwent cardiac surgery in a tertiary care center, from July 2016 through December 2019. Patients with preexisting tracheostomy upon admission for cardiac surgery were excluded. The medical records of patients who had speech-language pathology consultation orders for swallowing concerns were analyzed in order to compare the timing of speech-language pathology order entry, completion of speech-language pathology evaluation, and incidence of pneumonia during hospitalization following cardiac surgery.

Results:

During the study period, 3,168 patients underwent cardiac surgery, of which 2,864 patients met the inclusion criteria. Speech-language pathology was ordered for 473 cases (16.5%), and clinical swallow evaluation (CSE) was completed by speech-language pathology in 419 patients (88.6%), of which 309 patients were suspected to have dysphagia (73.7%). Among the 2,391 patients without speech-language pathology consultation, pneumonia was reported in 34 patients (1.42%). Pneumonia was reported in 53 patients in the speech-language pathology cohort, of which 43 patients (13.9%) were suspected to have dysphagia. Patients with pneumonia had significantly longer median time (20.0 hr, range: 4.9–26.7) from speech-language pathology orders to completion of CSE, compared to those without pneumonia (13.2 hr, range: 3.2–22.4,
p
= .025). There was no significant difference in the median time from extubation to speech-language pathology consultation order time in patients with pneumonia versus those without pneumonia. Patients with pneumonia were observed to have prolonged, although not statistically significant, median time from extubation to CSE (70.4 hr, range: 21.2–215) compared to those without pneumonia (42.2 hr, range: 19.5–105.8,
p
= .066).

Conclusions:
Patients without pneumonia in the postoperative period were observed to have shorter median time from extubation to speech-language pathology evaluation. Future studies are needed to further understand the impact of early speech-language pathology consultation and incidence of pneumonia in this population.
Prevalence Versus Evidence: A Closer Look at the Research Available for Serving Children Exposed to Maltreatment and a Response to Hyter's Call for Trauma-Informed Care
Authors: Gayaldo Savanah , Gladfelter Allison 
Published: August 2022

Purpose:

In an October 2021 post of
The ASHA LeaderLive
, Dr. Yvette Hyter emphasized the need for trauma-informed services for children exposed to maltreatment in the wake of the COVID-19 pandemic. Inspired by her call, we discuss how the pandemic created a high-risk context for maltreatment, the speech-language pathologists' (SLPs') role in prevention and intervention, reflect on the gap in evidence for maltreatment within empirical journals aimed at the speech-language pathology audience, and reiterate Hyter's call for trauma-informed care as a guide for clinicians serving children exposed to maltreatment.

Method:
We searched for empirical evidence within journals aimed at SLPs focused on maltreatment to get an estimate of the available research. For comparison, we consulted the same journals for the number of publications covering other risk factors or conditions with similar impacts on communication skills but with lower prevalence rates.

Results:
Compared to other risk factors or conditions with lower prevalence rates, the disparity between the evidence aimed at SLPs and the prevalence of childhood maltreatment was difficult to ignore.

Conclusion:
Given the current circumstances, we encourage clinicians to seek information about the communicative effects of exposure to maltreatment beyond journals aimed specifically at speech-language pathologists, stress the need for trauma-informed care instruction during graduate schooling, increase awareness of our role in preventative care, and call for more research on intervention services tailored specifically for children exposed to maltreatment.
Full-length standing radiographs can be used for determination of the Femoral neck-shaft angle but not acetabular coverage
Authors: Ahmad Sufian S. , Konrads Christian , Steinmeier Annika , Ettinger Max , Windhagen Henning , Giebel Gregor M. 
Published: August 2022

Introduction: The exact evaluation of hip morphology is essential for surgical planning. A wide range of morphometric measures of the acetabulum is deduced from conventional anterior-posterior (ap) pelvic radiographs. Full-length weight-bearing radiographs (FLWBR) also depict the acetabulum and are commonly used for osteotomy planning of the lower limb. This study aimed to determine whether FLWBR can be used to evaluate acetabular morphology. Methods: Radiographs of patients receiving a hip workup that included a conventional ap pelvic X-ray and FLWBR were utilized for radiographic measurements. The following parameters were measured: extrusion index of the femoral head, anterior wall index, posterior wall index, lateral center edge angle (LCE), acetabular index, pubic arc angle (subpubic angle), and centrum-collum-diaphyseal angle (CCD). Results: FLWBR depicted a significantly reduced anterior coverage (p = 0.049) and increased posterior coverage (p < 0.001), higher acetabular index (p = 0.015), and higher pubic-arc angle (p = 0.02) compared to conventional ap pelvic radiographs. There were no significant differences regarding the CCD angle (p = 0.28), extrusion index (p = 0.31), and LCE (p = 0.16). Discussion: The CCD angle of the femur can be measured on conventional ap radiographs and full-length weight-bearing X-rays for lower limb deformity analysis. However, FLWBR will depict an anteverted acetabular morphology, rendering conventional ap radiographs necessary for planning pelvic osteotomies.
Medikamenteninduzierte Lungenveränderungen und unerwünschte Nebenwirkungen
Authors: Meiler Stefanie , Hamer Okka Wilkea 
Published: August 2022

ZusammenfassungBereits mehrere Hundert Substanzen sind als potenziell lungenschädigend bekannt. Zu den häufigsten Auslösern einer medikamentös induzierten Pneumonitis („drug-related pneumonitis“, DRP)
zählen Chemotherapeutika, antiinflammatorische Medikamente, kardiovaskuläre Medikamente und Antibiotika. Die Einführung der Biologika/Immuntherapeutika in die Krebstherapie hat die Inzidenz
weiter erhöht.
Diagnostik und Behandlung von duralen AV-Fisteln
Authors: Solymosi László 
Published: August 2022

ZusammenfassungDurale arteriovenöse Fisteln machen 10 – 15% aller intrakraniellen Gefäßmalformationen aus. Sie werden heute als erworbene Erkrankungen angesehen, die nach Sinus- und/oder Venenthrombosen,
Traumen und Operationen auftreten. Radiologische Aufnahmen, die diese Fisteln zeigen, werden nicht selten fehlinterpretiert. Im folgenden Beitrag sind die typischen Veränderungen
insbesondere im Hinblick auf die Bildgebung dargestellt.
Comparison of Glioblastoma Outcomes in Two Geographically and Ethnically Distinct Patient Populations in Disparate Health Care Systems
Authors: Mirza Farhan A. , Baqai Muhammad Waqas S. , Hani Ummey , Hulou Maher , Shamim Muhammad Shahzad , Enam Syed Ather , Pittman Thomas 
Published: August 2022

Abstract
Introduction Variations in glioblastoma (GBM) outcomes between geographically and ethnically distinct patient populations has been rarely studied. To explore the possible similarities and differences, we performed a comparative analysis of GBM patients at the University of Kentucky (UK) in the United States and the Aga Khan University Hospital (AKUH) in Pakistan.
Methods A retrospective review was conducted of consecutive patients who underwent surgery for GBM between January 2013 and December 2016 at UK, and July 2014 and December 2017 at AKUH. Patients with recurrent or multifocal disease on presentation and those who underwent only a biopsy were excluded. SPSS (v.25 IBM, Armonk, New York, United States) was used to collect and analyze data.
Results Eighty-six patients at UK (mean age: 58.8 years; 37 [43%] < 60 years and 49 [57%] > 60 years) and 38 patients at AKUH (mean age: 49.1 years; 30 (79%) < 60 years and 8 (21%) > 60 years) with confirmed GBM were studied. At UK, median overall survival (OS) was 11.5 (95% confidence interval [CI]: 8.9–14) months, while at AKUH, median OS was 18 (95% CI: 13.9–22) months (p = 0.002). With gross-total resection (GTR), median OS at UK was 16 (95% CI: 9.5–22.4) months, whereas at AKUH, it was 24 (95% CI: 17.6–30.3) months (p = 0.011).
Conclusion Median OS at UK was consistent with U.S. data but was noted to be longer at AKUH, likely due to a younger patient cohort and higher preoperative Karnofsky's performance scale (KPS). GTR, particularly in patients younger than 60 years of age and a higher preoperative KPS had a significant positive impact on OS and progression-free survival (PFS) at both institutions.