bluuebunny/crossref_metadata_2025_split huggingface dataset:
Older adults' physical activity after lockdown: Testing the health action process approach and the moderating role of fear of Covid‐19
Authors: Bösch Valérie D. , Inauen Jennifer 
Published: July 2022

AbstractThe coronavirus pandemic has influenced many lives, particularly older adults'. Although isolation protects from infection, health behaviors like physical activity (PA) are important to reinstate after lockdown. However, fear of Covid‐19 may act as a barrier, for example, by preventing people from going outside. Based on the health action process approach (HAPA), we investigated whether and why older adults' PA changed after lockdown, and whether fear of Covid‐19 moderates the intention–behavior relationship. Participants of this longitudinal study aged 65+ from German‐speaking Europe completed an online questionnaire about their PA, fear of Covid‐19, and HAPA factors in April and May 2020. Data were analyzed using multiple linear regressions. Results showed that moderate to vigorous activity (MVPA) remained stable after lockdown and that self‐efficacy most robustly influenced the intention to be active. PA was not explained by any volitional factor but was strongly related to past PA. Interestingly, the relationship of past and future MVPA was attenuated by fear of Covid‐19, but this finding was not robust when outliers were removed. In conclusion, self‐efficacy is the most important motivator for PA in older adults after an interruption like a lockdown. Strong physical activity habits may facilitate PA after a period of isolation.
A unique skin phenotype resulting from a large heterozygous deletion spanning six keratin genes
Authors: Mohamad Janan , Sarig Ofer , Beattie Paula , Malovitski Kiril , Assaf Sari , O’Toole Edel , Schwartz Janice , Evans Holly , Samuelov Liat , Sprecher Eli 
Published: July 2022

Abstract

The phenotypic spectrum of genodermatoses is continuously expanding. Three siblings were referred because of a highly unusual phenotype comprising alopecia, dystrophic nails, palmoplantar keratoderma and trauma-induced skin blistering. Whole-exome sequencing analysis identified a heterozygous large genomic alteration of around 116 0000 bp resulting in the deletion of the KRT9, KRT14, KRT15, KRT16 and KRT19 genes, as well as part of KRT17. This genomic change leads to the generation of a truncated keratin 17 (KRT17) protein encoded by the first three exons of the gene and part of intron 3. The three patients were found to carry the heterozygous genomic deletion while their healthy parents did not, indicative of germline mosaicism. The genomic alteration was found to result in reduced KRT17 expression in patient skin. More importantly, the abnormal truncated KRT17 was found to exert a deleterious effect on keratinocyte cytoskeleton formation, leading to keratin aggregation. Coexpression of wildtype and truncated KRT17 proteins also caused keratin aggregation, demonstrating that the deletion exerts a dominant negative effect. In conclusion, we are reporting on a novel clinical phenotype that was found to result from germline mosaicism for a large genomic deletion spanning six keratin genes, thus expanding the spectrum of clinical manifestations associated with keratin disorders.
What is already known about this topic? Various conditions known as keratinopathies have been shown over recent years to be associated with dominant or recessive variants in several individual keratin genes.
What does this study add? We report three patients presenting with a unique clinical phenotype that was found to result from germline mosaicism for a large genomic deletion spanning six keratin genes.The genomic variant is predicted to result in a truncated form of keratin 17, which was found in an in vitro assay to disrupt keratinocyte cell cytoskeleton formation.
Neurocognitive and neurobehavioral characterization of two frequent forms of neurodevelopmental disorders: the DYRK1A and the Wiedemann–Steiner syndromes
Authors: Durand Benjamin , Schaefer Elise , Burger Pauline , Baer Sarah , Schroder Carmen , Mandel Jean‐Louis , Piton Amélie , Coutelle Romain 
Published: July 2022

AbstractDYRK1A and Wiedemann–Steiner syndromes (WSS) are two genetic conditions associated with neurodevelopmental disorders (NDDs). Although their clinical phenotype has been described, their behavioral phenotype has not systematically been studied using standardized assessment tools. To characterize the latter, we conducted a retrospective study, collecting data on developmental history, autism spectrum disorder (ASD), adaptive functioning, behavioral assessments, and sensory processing of individuals with these syndromes (n = 14;21). In addition, we analyzed information collected from families (n = 20;20) using the GenIDA database, an international patient‐driven data collection aiming to better characterize natural history of genetic forms of NDDs. In the retrospective study, individuals with DYRK1A syndrome showed lower adaptive behavior scores compared to those with WSS, whose scores showed greater heterogeneity. An ASD diagnosis was established for 57% (8/14) of individuals with DYRK1A syndrome and 24% (5/21) of those with WSS. Language and communication were severely impaired in individuals with DYRK1A syndrome, which was also evident from GenIDA data, whereas in WSS patients, exploration of behavioral phenotypes revealed the importance of anxiety symptomatology and ADHD signs, also flagged in GenIDA. This study, describing the behavioral and sensorial profiles of individuals with WSS and DYRK1A syndrome, highlighted some specificities important to be considered for patients' management.
Impact of molecular and clinical variables on survival outcome with immunotherapy for glioblastoma patients: A systematic review and meta‐analysis
Authors: Hu Wentao , Liu Hongyu , Li Ze , Liu Jialin , Chen Ling 
Published: July 2022

AbstractBackgroundGiven that only a subset of patients with glioblastoma multiforme (GBM) responds to immuno‐oncology, this study aimed to assess the impact of multiple factors on GBM immunotherapy prognosis and investigate the potential predictors.MethodsA quantitative meta‐analysis was conducted using the random‐effects model. Several potential factors were also reviewed qualitatively.ResultsA total of 39 clinical trials were included after screening 1317 papers. Patients with O6‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation [hazard ratio (HR) for overall survival (OS) = 2.30, p < 0.0001; HR for progression‐free survival (PFS) = 2.10, p < 0.0001], gross total resection (HR for OS = 0.70, p = 0.02; HR for PFS = 0.56, p = 0.004), and no baseline steroid use (HR for OS = 0.52, p = 0.0002; HR for PFS = 0.61, p = 0.02) had a relatively significant favorable OS and PFS following immunotherapy. Patients with a Karnofsky Performance Status score < 80 (HR = 1.73, p = 0.0007) and undergoing two prior relapses (HR = 2.08, p = 0.003) were associated with worse OS. Age, gender, tumor programmed death‐ligand 1 expression, and history of chemotherapy were not associated with survival outcomes. Notably, immunotherapy significantly improved the OS among patients undergoing two prior recurrences (HR = 0.40, p = 0.008) but not among patients in any other subgroups, as opposed to non‐immunotherapy.ConclusionSeveral factors were associated with prognostic outcomes of GBM patients receiving immunotherapy; multiple recurrences might be a candidate predictor. More marker‐driven prospective studies are warranted.
Extending the use of the Endoscopic Endonasal Sinus and Skull Base Surgery Questionnaire in a cross‐sectional study: Patients with chronic rhinosinusitis versus healthy controls
Authors: Joustra Gonneke E. , den Heijer Marc C. , Vermeulen Karin M. , Feijen Robert A. , Korsten‐Meijer Astrid G. W. 
Published: July 2022

AbstractObjectivesThere are several instruments to assess health‐related quality of life (HRQoL) in chronic rhinosinusitis (CRS). Unfortunately, none of them evaluates all three health domains (physical, social and psychological) important to assess the overall well‐being of the patient. The Endoscopic Endonasal Sinus and Skull Base Surgery Questionnaire (EES‐Q) does assess all these elements. Initially, the EES‐Q is validated to evaluate the impact of endoscopic endonasal surgery (EES) on HRQoL. The aim of this study is to assess whether EES‐Q outcomes differ in patients with CRS compared with healthy individuals. Therefore, extending the use of the EES‐Q for all CRS patients.DesignCross‐sectional study.SettingTertiary referral hospital.ParticipantsOne hundred patients with uncontrolled CRS (50% with nasal polyps) scheduled to receive EES. The questionnaire was completed preoperatively. Healthy control subjects (n = 100) without any history of sinusitis or a known current medical treatment at a hospital were included.Main outcome measuresMann–Whitney U test was performed to identify differences in EES‐Q scores (domain scores and EES‐Q score).ResultsThe median EES‐Q score in CRS patients (33.8) was significantly higher (p < 0.001) than in the control group (10.4). As well as the physical (52.5 vs. 16.4, p < 0.001), psychological (13.8 vs. 5.0, p < 0.001) and social (37.5 vs. 2.5, p < 0.001) domain scores.ConclusionsWith this study, we are extending the use of the EES‐Q. It indicates that the EES‐Q can be a valuable clinical tool to assess multidimensional HRQoL in all patients with CRS.
Impact of the ‘10,000 lives’ program on Quitline referrals, use and outcomes by demography and Indigenous status
Authors: Khan Arifuzzaman , Green Kalie , Medlin Linda , Khandaker Gulam , Lawler Sheleigh , Gartner Coral 
Published: July 2022

AbstractIntroductionIn November 2017, Central Queensland Public Health Unit launched the ‘10,000 Lives’ initiative to reduce smoking prevalence in Central Queensland. The program partnered with local champions and other programs (e.g. ‘Deadly Choices’) to promote the use of smoking cessation services (e.g. Quitline) in Central Queensland. This study assesses the program's impact on Quitline use by participant demographics and Indigenous status.MethodsWe compared the number of referred individuals who participated in and completed the Quitline program, and quit smoking during 26‐months before (July 2015 to August 2017) and after (November 2017 to December 2019) the ‘10,000 Lives’ launch. We conducted an interrupted time series analysis of monthly referrals to and use of Quitline for Aboriginal and Torres Strait Islander peoples.ResultsOverall, 3207 individuals were referred to Quitline during the 26‐months‐post‐launch compared to 1594 during 26‐months‐pre‐launch period of ‘10,000 Lives’. The number of referred individuals who completed Quitline program increased by 330.7% and quit smoking by 308.3% in post‐launch period. The increase was substantially higher among aged 45+ years, females and Aboriginal and Torres Strait Islander peoples. The result for referrals and use of Quitline was validated by interrupted time series analysis for Aboriginal and Torres Strait Islander peoples.Discussion and ConclusionsThe ‘10,000 Lives’ collaborative approach to partner with local champions and targeted smoking cessation programs was effective in increasing the use of Quitline and smoking cessation among all demographic groups, including Aboriginal and Torres Strait Islander peoples. This approach can be used in other regions to address higher smoking prevalence.
Fixed prosthodontics clinical unit completions in an undergraduate curriculum: A 10‐year retrospective study
Authors: Dudley James 
Published: July 2022

AbstractIntroductionProviding undergraduate dental students with a range of clinical experiences in fixed prosthodontics procedures is an important component of dental education. The aim of this retrospective study was to analyse the types of laboratory‐fabricated fixed prosthodontics clinical units completed by undergraduate students over 10 consecutive years and determine any significant trends.Materials and MethodsThe fixed prosthodontics treatment registers from 2012 to 2021 were reviewed and the different types of completed fixed prosthodontics units and total number of fixed prosthodontics units were recorded for each year. Completed units were categorised according to the type of restoration and expressed in whole numbers and as a percentage of the total number of units completed in each year. The data were presented in table and graph form. Mann‐Kendall tests were performed to statistically analyse for trends in the different restoration types.ResultsThroughout all study years, porcelain bonded to metal (PBM) crowns (48.25%, range 35.70%–59.91%) were the most frequently completed fixed prosthodontics unit followed by full gold crowns (FGC) (20.84%, range 14.89%–27.30%) and all‐ceramic crowns (ACC) (12.70%, range 3.67%–24.41%). Collectively, PBM, FGC and ACC comprised 81.80% of all completed fixed prosthodontics units. There were observed trends of increased use of all types of all‐ceramic containing restorations, all types of all‐gold containing restorations, all types of partial coverage restorations and specifically ceramic onlays and gold onlays. There were observed trends of reduced use of cast gold post‐cores and all types of bridges.ConclusionPBM crowns were the mainstay laboratory‐fabricated fixed prosthodontic unit completed over 10 years of undergraduate student fixed prosthodontics clinical practice.
Measuring dysfunctional parenting: Psychometrics of three versions of the Parenting Scale
Authors: Prandstetter Katharina , Waller Franziska , Heinrichs Nina , Hutchings Judy , Ward Catherine L. , Dănilă Ingrid , Lachman Jamie M. , Foran Heather M. 
Published: July 2022

AbstractObjectiveThis study assessed the psychometric properties of three versions of the Parenting Scale (PS; original PS, 13‐item version, and 10‐item version) in three European middle‐income countries.BackgroundThe PS is one of the most frequently used questionnaires for measuring dysfunctional discipline strategies. Although its validity has been extensively investigated in American samples, there are mixed results regarding the recommended number of items and subscales, raising the question of replicability across European middle‐income countries.MethodMultigroup confirmatory factor analysis (MCFA) and item response theory (IRT) were applied to N = 835 parents from North Macedonia, Moldova, and Romania.ResultsAll three versions were significantly correlated with parental‐ and child‐related variables. Confirmatory factor analysis indicated the best model fit for the 10‐item version, and configural and partial metric invariance across countries could be established for this version. Item response theory analyses also supported this measure.ConclusionsOur findings show that the 10‐item version performed better than the 13‐item version and the original PS both overall and on the country level. Reliability values were somewhat lower than reported in studies from the United States.ImplicationsThe 10‐item version constitutes a promising short measure for assessing dysfunctional parenting in European middle‐income countries for researchers and practitioners.
On micro‐defect induced cracking in very high cycle fatigue regime
Authors: Zhu Ming‐Liang , Zhu Gang , Xuan Fu‐Zhen 
Published: July 2022

AbstractIt is known that fine granular area morphology is often formed around interior micro‐defect in the case of very high cycle fatigue failure of high strength steel. The mechanism of “fragmentation of martensitic laths and formation of dislocation cells” (Zhu's model), which revealed a microstructure‐dependent crack initiation and early growth for micro‐defect induced internal fatigue cracking, was discussed in several lathy martensitic or similar steels, verified under environmental fatigue, and applicable to white etching crack in rotating contact fatigue. A machine learning‐Z parameter integrated approach was developed for fatigue life, which is promising for design against fatigue of engineering structures for long life.
Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists
Authors: Johnson Kirk W. , Li Xia , Huang Xiaofang , Heinz Beverly A. , Yu Jianliang , Li Baolin 
Published: July 2022

AbstractObjectiveTo characterize the effects of blocking calcitonin gene‐related peptide (CGRP) activity in a mouse model of gastrointestinal transport.BackgroundMigraine management using CGRP modulating therapies can cause constipation of varying frequency and severity. This variation might be due to the different mechanisms through which therapies block CGRP activity (e.g., blocking CGRP, or the CGRP receptor) with antibodies or receptor antagonists. The charcoal meal gastrointestinal transit assay was used to characterize constipation produced by these modes of therapy in transgenic mice expressing the human receptor activity–modifying protein 1 (hRAMP1) subunit of the CGRP receptor complex.MethodsMale and female hRAMP1 mice were dosed with compound or vehicle and challenged with a charcoal meal suspension via oral gavage. The mice were then humanely euthanized and the proportion of the length of the large intestine that the charcoal meal had traveled indicated gastrointestinal transit.ResultsAntibody to the CGRP receptor produced % distance traveled (mean ± standard deviation) of 31.8 ± 8.2 (4 mg/kg; p = 0.001) and 33.2 ± 6.0 (30 mg/kg; p < 0.001) compared to 49.7 ± 8.3 (control) in female mice (n = 6–8), and 35.6 ± 13.5 (30 mg/kg, p = 0.019) compared to 50.2 ± 14.0 (control) in male mice (n = 10). Telcagepant (5 mg/kg, n = 8) resulted in % travel of 30.6 ± 14.7 versus 41.2 ± 8.3 (vehicle; p = 0.013) in male mice. Atogepant (3 mg/kg, n = 9) resulted in % travel of 30.6 ± 12.0, versus 41.2 ± 3.7 (control; p = 0.030) in female mice. The CGRP antibody galcanezumab (n = 7–10; p = 0.958 and p = 0.929) did not have a statistically significant effect.ConclusionsThese results are consistent with reported clinical data. Selectively blocking the CGRP receptor may have a greater impact on gastrointestinal transit than attenuating the activity of the ligand CGRP. This differential effect may be related to physiologically opposing mechanisms between the CGRP and AMY1 receptors, as the CGRP ligand antibody could inhibit the effects of CGRP at both the CGRP and AMY1 receptors.
Consumers under pandemic anxiety: Suppressors, intensifiers, and resilients
Authors: Mittal Banwari 
Published: July 2022

AbstractCOVID‐19 turned the lives of all people across the world upside down. Everyone faced the threat of catching the virus and denial of access to the physical marketplace. For many, it also brought the threat of partial or full unemployment. This trinity of upheaval produced heightened anxiety. The purpose of this article is to understand how consumers coped with anxiety during the pandemic and lockdown periods. We hypothesized that consumers coped with such anxiety by engaging in diverse creative and productive activities, which served as anxiety suppressors. In addition, we hypothesized that one's enduring mind positivity provided resilience and helped consumers mitigate their anxiety. In survey data from a random sample of 550 consumers in the United States, we found support for these hypotheses. Consumers who engaged in voluntary productive activities suffered less anxiety. And consumers with higher resilience levels also felt lower levels of anxiety. In addition, we found that enjoyment of shopping intensified the experience of COVID‐19‐induced anxiety. The research framework linking this specific set of antecedents to COVID‐induced anxiety and its affirmation in this study are new to the literature and therefore offer a notable contribution to it. These findings show two pathways to marketers: Organize and promote voluntary productive activities and offer means for consumers to cultivate personal resilience, on for‐profit and not‐for‐profit platforms. Also, we suggest a future consumer research agenda for when fate again brings us face‐to‐face with similar or even lesser catastrophes, which, according to scientific forecasters, it sadly but surely will.
Patient satisfaction with nursing care: A bibliometric and visualization analysis (1950–2021)
Authors: Sweileh Waleed M. 
Published: July 2022

AbstractAimThe current study aimed to provide an overview of research publications on patient satisfaction with nursing care.BackgroundResearch activity on patient satisfaction with nursing care is an indicator of the commitment of policymakers to improve the quality of health services.DesignThis was a descriptive cross‐sectional bibliometric study.MethodsThe Scopus database was used to retrieve relevant documents for the period from 1950 to 31 December 2021. The keywords ‘patient satisfaction’ and ‘nursing care’ were used in the search strategy. Two volunteers validated the search strategy.ResultsThe search strategy found 387 documents authored by 1470 researchers and disseminated through 241 journals. Research on patient satisfaction with nursing care (a) has experienced a steep growth over the last decade; (b) was mainly published by scholars from a limited number of countries; (c) has limited cross‐country collaboration and limited author collaboration; (d) has addressed research topics concerning the quality of care, instrument validation, emergency department and hospital care and (e) has shown the highest readability for topics related to nurses' burnout and patient satisfaction.ConclusionResearchers and educators, especially in low‐ and middle‐income countries, need to focus on this field to support activities to upgrade health services and patient outcomes.
Mapping active and collaborative learning in higher education through annotations in hyper‐video by learning analytics
Authors: Sidi Yael , Blau Ina , Shamir‐Inbal Tamar 
Published: July 2022

AbstractBackgroundHyper‐video technology allows reflection on learning materials by writing personal notes and by interactions with lecturers and peers through shared posts and replies. While research shows that integrating hyper‐videos in educational systems can promote the learning processes and outcomes, an open question remains regarding its actual utilization patterns by students and teachers.ObjectivesThe study aimed to reveal the extent to which students utilize different functions of hyper‐videos in real‐life learning contexts, and to examine the role of instructional design on hyper‐video utilization.MethodIn a mixed‐method design, the study characterized active and passive interactions in hyper‐videos in higher education courses, and amongst active interactions, compared shared versus private annotations. Additionally, the study compared voluntary and mandatory instructional design for promoting hyper‐video interactions. In particular, we used learning analytics to explore hyper‐video patterns in 25 undergraduate and graduate courses.Results and DiscussionA log analysis revealed that students wrote most of the posts, while lecturers mainly provided replies to students' posts. Private annotations were more prevalent than shared writing, pointing to the unfulfilled potential of hyper‐video annotations to benefit from collaborative learning. A qualitative analysis on instructional design was consistent with quantitative findings, revealing important differences between the courses with mandatory versus voluntary hyper‐video integration in pedagogical design, and in cognitive presence and teaching presence, based on the community of inquiry framework.Major takeawaysFindings point to an unfulfilled potential of hyper‐video technology to promote active and collaborative learning. This highlights the role of design and instructive guidance when integrating technology into educational systems.