bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric Response of Sea Surface Salinity to Extreme Positive and Negative Indian Ocean Dipole in the Southern Tropical Indian Ocean
Authors: Sun Qiwei , Zhang Yuhong , Du Yan , Jiang Xingwei 
Published: October 2022

AbstractBased on the Argo and multi‐satellite observations, this study investigates the asymmetric response of sea surface salinity (SSS) to two extreme positive and negative Indian Ocean Dipole (IOD) events in the southern tropical Indian Ocean (TIO). During positive IOD events, the easterly wind anomalies trigger zonal freshwater advection along the equator, decreasing SSS, while cold sea surface temperature (SST) depress the convective precipitation in the southeastern TIO (SETIO), increasing the SSS. Contrast SSS anomalies along the equator and in the SETIO show opposite phases during positive and negative IOD events. These SSS anomalies have enhanced in recent years, reaching the strongest in the extreme negative IOD in 2016 and positive IOD in 2019. The case study shows that positive SSS anomalies occurred in the southern TIO during both positive and negative IOD events in 2016 and 2019, suggesting significant asymmetry in SSS. Analysis of the mixed layer salinity budget shows that the local precipitation and the entrainment associated with the upwelling Rossby waves played an essential role in the SSS increase in 2016, while the decreased precipitation and horizontal advection caused by the westward South Equatorial Current contributed to the SSS increase in 2019. Further analyses suggest that SSS response is more sensitive to thermocline shoaling than deepening, and SSS response to precipitation is greater at shallower mixed layer than at deeper ones, which is the main reason for the asymmetric response of the SSS to negative and positive IOD events.
LRO‐LAMP Survey of Lunar South Pole Cold Traps: Implication for the Presence of Condensed H2O
Authors: Magaña L. O. , Retherford K. D. , Byron B. D. , Hendrix A. R. , Grava C. , Mandt K. E. , Raut U. , Czajka E. , Hayne P. O. , Hurley D. M. , Gladstone G. R. , Poston M. J. , Greathouse T. K. , Pryor W. , Cahill J. T. , Stickle A. 
Published: October 2022

AbstractWe employ nighttime observations from the Lyman Alpha Mapping Project (LAMP) ultraviolet (UV) spectrograph onboard the Lunar Reconnaissance Orbiter to investigate the presence of condensed water ice within lunar south pole cold traps. This study incorporates LAMP observations between 2009 and 2016, which more than doubles the number of observations from previous LAMP Permanently Shadowed Regions (PSRs) studies. In this study, we focus on cold traps within five south polar craters: Faustini, Shoemaker, Haworth, Cabeus, and Amundsen. An unnamed cold trap region adjacent to Haworth and Shoemaker was also investigated. We present On‐band (148–162 nm), Edge‐band (164–173 nm), and Off‐band (175–190 nm) albedo maps at 4‐km spatial resolution and far‐UV albedo spectra of cold traps at 2‐nm spectral resolution. We find Off‐band to On‐band albedo ratios (the UV wavelength ranges with high and low H2O ice reflectivity, respectively) within cold traps that are consistent with previous PSR studies. Spectral intimate mixture models considering 5 μm H2O grains and a range of regolith grain sizes (20–74 μm) with porosities between 0.3 and 0.75 yields abundances of ∼0.9–4.9 wt.%, where increasing the range of H2O and regolith grain sizes may increase the range of water abundance. We further find generally lower albedos within the cold trap regions than at the surrounding non‐cold trap regions across all wavelengths, consistent with increased regolith porosity within cold traps as suggested by Gladstone et al. (2012), https://doi.org/10.1029/2011JE003913.
Rock Magnetic Characterization of Returned Samples From Asteroid (162173) Ryugu: Implications for Paleomagnetic Interpretation and Paleointensity Estimation
Authors: Sato Masahiko , Kimura Yuki , Tanaka Satoshi , Hatakeyama Tadahiro , Sugita Seiji , Nakamuna Tomoki , Tachibana Shogo , Yurimoto Hisayoshi , Noguchi Takaaki , Okazaki Ryuji , Yabuta Hikaru , Naraoka Hiroshi , Sakamoto Kanako , Yada Toru , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Yogata Kasumi , Abe Masanao , Okada Tatsuaki , Usui Tomohiro , Yoshikawa Makoto , Saiki Takanao , Terui Fuyuto , Nakazawa Satoru , Watanabe Sei‐ichiro , Tsuda Yuichi 
Published: October 2022

AbstractIn this study, systematic rock magnetic measurements and saturation isothermal remanent magnetization (SIRM) paleointensity calibration experiments were conducted for the returned samples from C‐type asteroid (162173) Ryugu and two carbonaceous chondrites (Orgueil and Tagish Lake) to evaluate the remanence carriers of the Ryugu sample and its ability as a paleomagnetic recorder. Our magnetic measurements show that Ryugu samples exhibit signatures for framboidal magnetite, coarse‐grained magnetite, and pyrrhotite, and that framboidal magnetite is the dominant remanence carrier of Ryugu samples in the middle‐coercivity range. The SIRM paleointensity constant was obtained for two Ryugu samples, and the median value was 3,318 ± 1,038 μT, which is close to the literature's value based on the average among magnetite, titanomagnetite, pyrrhotite, and FeNi alloys and is widely used for SIRM paleointensity experiments. The paleointensity values estimated using the obtained SIRM paleointensity constant indicate a strong magnetic field of the protoplanetary disk, suggesting that Sun's protoplanetary disk existed at the disk location of Ryugu's parent planetesimal when framboidal magnetite precipitated from the aqueous fluid.
Orbital and In Situ Investigation of the Bagnold Dunes and Sands of Forvie, Gale Crater, Mars
Authors: Moreland E. L. , Arvidson R. E. , Morris R. V. , Condus T. , Hughes M. N. , Weitz C. M. , VanBommel S. J. 
Published: October 2022

AbstractThe Bagnold linear dune field investigated by Curiosity at Mount Desert Island (MDI) is north of the ∼5.5 km high Aeolis Mons mound in Gale crater. False‐color images (RGB: 2.496, 1.802, and 1.237 μm, respectively) generated from Mars Reconnaissance Orbiter Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) data show the dune field has a reddish‐brown color. The Sands of Forvie (SoF), located ∼2.5 km to the southeast of MDI, is darker and lacks the reddish‐brown color. Single scattering albedo (SSA) spectra retrieved at 12 m/pixel using along‐track oversampled CRISM observation FRT00021C92 show a long wavelength (1.7–2.5 μm) increase in albedo for MDI dunes. For the same wavelength interval, SoF is characterized by a broad ∼2.2 μm absorption feature, consistent with color differences between the two deposits. Checkerboard un‐mixing of the SSA image cube was used to isolate spectral endmembers within the MDI and SoF deposits. Radiative modeling of these CRISM spectral endmembers using Hapke (2012, https://doi.org/10.1017/CBO9781139025683) theory implies finer grain sizes, more pigeonite, plagioclase, and olivine, and less basaltic glass and augite for MDI as compared to the SoF deposit. These results are consistent with Curiosity‐based observations that MDI contains smaller ripples with overall finer grains, whereas SoF has large ripples with coarser grains on the crests. Although these sand deposits are only located ∼2.5 km away from one another, wind and local topographic controls are interpreted to have modulated grain sizes and mineralogy.
Integrated 64 pixel UV image sensor and readout in a silicon carbide CMOS technology
Authors: Romijn Joost , Vollebregt Sten , Middelburg Luke M. , Mansouri Brahim El , van Zeijl Henk W. , May Alexander , Erlbacher Tobias , Leijtens Johan , Zhang Guoqi , Sarro Pasqualina M. 
Published: October 2022

AbstractThis work demonstrates the first on-chip UV optoelectronic integration in 4H-SiC CMOS, which includes an image sensor with 64 active pixels and a total of 1263 transistors on a 100 mm2 chip. The reported image sensor offers serial digital, analog, and 2-bit ADC outputs and operates at 0.39 Hz with a maximum power consumption of 60 μW, which are significant improvements over previous reports. UV optoelectronics have applications in flame detection, satellites, astronomy, UV photography, and healthcare. The complexity of this optoelectronic system paves the way for new applications such harsh environment microcontrollers.
Ectodermal origins of the skin-brain axis: a novel model for the developing brain, inflammation, and neurodevelopmental conditions
Authors: Jameson C. , Boulton K. A. , Silove N. , Nanan R. , Guastella A. J. 
Published: October 2022

AbstractEarly life development and its divergence is influenced by multiple genetic, neurological, and environmental factors. Atypical neurodevelopment, such as that observed in autism spectrum disorder, likely begins in early gestation during a period of entwined growth between the brain and epithelial barriers of the skin, gastrointestinal tract, and airway. This review coalesces epidemiological and neuroinflammatory evidence linking cutaneous atopic disease with both reduced skin barrier integrity and determinants of neurodivergence. We consider the shared developmental origin of epidermal and neural tissue with related genetic and environmental risk factors to evaluate potential pre- and postnatal modifiers of the skin-brain connection. Initial postnatal skin barrier integrity may provide a useful marker for both cortical integrity and meaningful subgroups of children showing early neurodevelopmental delays. It may also modify known risk factors to neurodevelopment, such as pathogen caused immune system activation. These novel insights of a skin-brain-neurodevelopment connection may advance detection and intervention opportunities.
The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells
Authors: Lee Moon Hee , Sung Kyung , Beebe David , Huang Wei , Shapiro Dan , Miyamoto Shigeki , Abel E. Jason 
Published: October 2022

AbstractWhile an important role for the SUMO protease SENP1 is recognized in multiple solid cancers, its role in renal cell carcinoma (RCC) pathogenesis, particularly the most dominant subtype, clear cell RCC (ccRCC), is poorly understood. Here we show that a combination of high HIF2α and SENP1 expression in ccRCC samples predicts poor patient survival. Using ccRCC cell models that express high HIF2α but low SENP1, we show that overexpression of SENP1 reduces sumoylation and ubiquitination of HIF2α, increases HIF2α transcriptional activity, and enhances expression of genes associated with cancer cell invasion, stemness and epithelial-mesenchymal transition. Accordingly, ccRCC cells with high HIF2α and SENP1 showed increased invasion and sphere formation in vitro, and local invasion and metastasis in vivo. Finally, SENP1 overexpression caused high HIF2α ccRCC cells to acquire resistance to a clinical mTOR inhibitor, everolimus. These results reveal a combination of high SENP1 and HIF2α expression gives particularly poor prognosis for ccRCC patients and suggest that SENP1 may be an attractive new target for treating metastatic RCC (mRCC).
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Authors: Song Chang-feng , Hu Yu-heng , Mang Zhi-guo , Ye Zeng , Chen Hai-di , Jing De-sheng , Fan Gui-xiong , Ji Shun-rong , Yu Xian-jun , Xu Xiao-wu , Qin Yi 
Published: October 2022

AbstractHernandezine (Her) is a bisbenzylisoquinoline alkaloid extracted from the traditional Chinese herbal medicine Thalictrum glandulosissimum. Evidence shows that Her is a natural agonist of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and induces apoptosis and autophagy in tumor cells. In this study, we investigated the role of autophagy in Her-induced cell death in human pancreatic cancer cell lines. We showed that Her dose-dependently suppressed cell proliferation, promoted autophagy and induced autophagic death in pancreatic ductal adenocarcinoma (PDAC) cell lines Capan-1 and SW1990. The IC50 values of Her in inhibition of Capan-1 and SW1990 cells were 47.7 μM and 40.1 μM, respectively. Immunoblotting showed that Her (1−40 μM) promoted the conversion of LC3-I to LC3-II, and Her exerted concentration-dependent and time-dependent effects on autophagy activation in PDAC cells. In transmission electron microscopy and fluorescence image analysis, we found that autophagic vacuoles were significantly increased in Her-treated cells. Knockdown of ATG5, a key gene in the autophagy pathway, alleviated the activation of autophagy by Her. These results demonstrated that Her induced autophagy in PDAC cells. Intensely activated autophagy could promote cell death. The autophagy inhibitors, BafA1 and HCQ significantly inhibited Her-induced cell death, implying that Her induced autophagic cell death in PDAC cells. Moreover, we showed that Her activated autophagy by increasing the phosphorylation of AMPK and decreasing the phosphorylation of mTOR/p70S6K. Knockdown of AMPKα relieves the autophagic cell death induced by Her. Furthermore, Her concentration-dependently enhanced reactive oxygen species (ROS) generation in PDAC cells. Antioxidants could reduce the phosphorylation of AMPK and suppress autophagic cell death induced by Her. Our study provides evidence for the development of Her as a therapeutic agent for the treatment of pancreatic cancer.
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
Authors: Zhang Tianyi , Ren Yanxian , Yang Pengfei , Wang Jufang , Zhou Heng 
Published: October 2022

AbstractPancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from tumour cells reduce the efficacy of conventional cancer treatment paradigms and contribute to tumour progression and metastasis. As abundant tumour-promoting cells in the ECM, cancer-associated fibroblasts (CAFs) are promising targets for novel anti-tumour interventions. Nonetheless, related clinical trials are hampered by the lack of specific markers and elusive differences between CAF subtypes. Here, we review the origins and functional diversity of CAFs and show how they create a tumour-promoting milieu, focusing on the crosstalk between CAFs, tumour cells, and immune cells in the tumour microenvironment. Furthermore, relevant clinical advances and potential therapeutic strategies relating to CAFs are discussed.
Electric-field control of the nucleation and motion of isolated three-fold polar vertices
Authors: Li Mingqiang , Yang Tiannan , Chen Pan , Wang Yongjun , Zhu Ruixue , Li Xiaomei , Shi Ruochen , Liu Heng-Jui , Huang Yen-Lin , Ma Xiumei , Zhang Jingmin , Bai Xuedong , Chen Long-Qing , Chu Ying-Hao , Gao Peng 
Published: October 2022

AbstractRecently various topological polar structures have been discovered in oxide thin films. Despite the increasing evidence of their switchability under electrical and/or mechanical fields, the dynamic property of isolated ones, which is usually required for applications such as data storage, is still absent. Here, we show the controlled nucleation and motion of isolated three-fold vertices under an applied electric field. At the PbTiO3/SrRuO3interface, a two-unit-cell thick SrTiO3layer provides electrical boundary conditions for the formation of three-fold vertices. Utilizing the SrTiO3layer and in situ electrical testing system, we find that isolated three-fold vertices can move in a controllable and reversible manner with a velocity up to ~629 nm s−1. Microstructural evolution of the nucleation and propagation of isolated three-fold vertices is further revealed by phase-field simulations. This work demonstrates the ability to electrically manipulate isolated three-fold vertices, shedding light on the dynamic property of isolated topological polar structures.
Synthetic Pseudo-Spin-Hall effect in acoustic metamaterials
Authors: Weiner Matthew , Ni Xiang , Alù Andrea , Khanikaev Alexander B. 
Published: October 2022

AbstractWhile vector fields naturally offer additional degrees of freedom for emulating spin, acoustic pressure field is scalar in nature, and it requires engineering of synthetic degrees of freedom by material design. Here we experimentally demonstrate the control of sound waves by using two types of engineered acoustic systems, where synthetic pseudo-spin emerges either as a consequence of the evanescent nature of the field or due to lattice symmetry. First, we show that evanescent sound waves in perforated films possess transverse angular momentum locked to their propagation direction which enables their directional excitation. Second, we demonstrate that lattice symmetries of an acoustic kagome lattice also enable a synthetic transverse pseudo-spin locked to the linear momentum, enabling control of the propagation of modes both in the bulk and along the edges. Our results open a new degree of control of radiation and propagation of acoustic waves thus offering new design approaches for acoustic devices.
Development of antibody-dependent cellular cytotoxicity in response to recombinant and live-attenuated herpes zoster vaccines
Authors: Park Seong Yeon , Levin Myron J. , Canniff Jennifer , Johnson Michael , Schmid D. Scott , Weinberg Adriana 
Published: October 2022

AbstractZoster vaccines generate antibody responses against varicella-zoster virus (VZV). We compared antibody-dependent cell cytotoxicity (ADCC) elicited by zoster vaccine live (ZVL) and recombinant zoster vaccine (RZV). ADCC mediated by antibodies against VZV lysate (VZV-ADCC) and recombinant glycoprotein E (gE-ADCC) was measured using plasma from 20 RZV- and 20 ZVL-recipients, including half 50–60-years-old and half ≥70-years-old. Solid phase-bound anti-VZV antibodies stimulated TNFα in NK cells as measured by flow cytometry or ELISA. VZV-ADCC pre- and post-immunization was higher in younger vaccinees. ZVL did not appreciably increase VZV-ADCC, whereas RZV increased VZV-ADCC in older vaccinees. ELISA-measured gE-ADCC was similar across groups pre-immunization; significantly increased after ZVL; and RZV and was higher in younger RZV than ZVL recipients. IgG3 antibodies increased after RZV and ZVL, with greater anti-gE than anti-VZV responses. Moreover, gE-ADCC strongly correlated with anti-gE antibody avidity, but there were no appreciable correlations between VZV-ADCC and avidity. NK cells stimulated by anti-gE antibodies showed increased IFNγ and CD107a expression, which was not observed with anti-VZV antibodies. In conclusion, anti-gE antibodies generated more robust ADCC than anti-VZV antibodies. RZV induced higher ADCC antibodies than ZVL depending on the antigen and age of vaccinees. Older adults had lower ADCC antibodies before and after vaccination than younger adults.
Gene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors
Authors: Ciceri Sara , Carenzo Andrea , Iannó Maria Federica , Bertolotti Alessia , Morosi Carlo , Luksch Roberto , Spreafico Filippo , Collini Paola , Radice Paolo , Massimino Maura , De Cecco Loris , Perotti Daniela 
Published: October 2022

AbstractIntra-tumor heterogeneity (ITH) fosters tumor evolution, resistance to therapy, and relapse. Recently, many evidence have been accumulated on the occurrence of genetic ITH in pediatric cancers. With this study we aimed to address the downstream effects that genetic and epigenetic ITH, and tumor-microenvironment interactions may produce within a tumor mass. To this aim, we investigated by high-throughput gene expression multiple samples of 5 hepatoblastomas, 5 neuroblastomas, 5 rhabdomyosarcomas, and 5 Wilms tumors. Principal component analysis, single sample hallmark gene sets analysis, and weighted gene co-expression network analysis were performed on gene expression data. We observed that the different tumors clustered by histotype, and then by case, and in addition, a variable degree of ITH was visible in all the investigated cases. The ITH highlighted in this study can represent a challenge in tumor treatment since we demonstrated that different druggable hallmarks and targets may be heterogeneously present within the same tumor mass, and this can potentially lead to therapeutic failure. Despite this heterogeneity, we could highlight some commonalities among the different histotypes investigated, supporting the feasibility to move in the clinic from a histotype-driven to a target-driven, sometimes agnostic, approach at least in some cases.
Omnidirectional flat bands in chiral magnonic crystals
Authors: Flores-Farías J. , Gallardo R. A. , Brevis F. , Roldán-Molina Alejandro , Cortés-Ortuño D. , Landeros P. 
Published: October 2022

AbstractThe magnonic band structure of two-dimensional chiral magnonic crystals is theoretically investigated. The proposed metamaterial involves a three-dimensional architecture, where a thin ferromagnetic layer is in contact with a two-dimensional periodic array of heavy-metal square islands. When these two materials are in contact, an anti-symmetric exchange coupling known as the Dzyaloshinskii–Moriya interaction (DMI) arises, which generates nonreciprocal spin waves and chiral magnetic order. The Landau–Lifshitz equation and the plane-wave method are employed to study the dynamic magnetic behavior. A systematic variation of geometric parameters, the DMI constant, and the filling fraction allows the examination of spin-wave propagation features, such as the spatial profiles of the dynamic magnetization, the isofrequency contours, and group velocities. In this study, it is found that omnidirectional flat magnonic bands are induced by a sufficiently strong Dzyaloshinskii–Moriya interaction underneath the heavy-metal islands, where the spin excitations are active. The theoretical results were substantiated by micromagnetic simulations. These findings are relevant for envisioning applications associated with spin-wave-based logic devices, where the nonreciprocity and channeling of the spin waves are of fundamental and practical scientific interest.