bluuebunny/crossref_metadata_2025_split huggingface dataset:
A NURSING PHILOSOPHY OF FAMILY EMPOWERMENT IN CARING UNDER-FIVE CHILDREN ILLNESS
Authors: Rachmawati Praba Diyan , Arief Yuni Sufyanti , Pandin Moses Glorino Rumambo 
Published: October 2022

AbstractIntroductionSick children will be at risk of experiencing growth and development disorders and experiencing severe conditions to decreased quality of life. Quality of care through proper management of sick children under five is a priority. However, in the field of pediatric nursing, there are still obstacles to the application of family empowerment in caring for sick children, so it is important to examine a literature review with a philosophical approach the application of family empowerment in caring for sick children, as an effort to optimize the care of sick children under-five.MethodThis study was based on the results of the Literature Review. Articles were obtained from 3 databases, namely Scopus, Science Direct and PubMed. The keywords used in searching the literature in this study were ((parent) OR (mother) AND (parental AND empowerment) OR (engagement) AND (children) OR (sick AND children)). Articles searched from 2018-2022, which were open access and in English, from this literature review search, found 12 articles.ResultBased on a philosophical approach of family empowerment in the care of sick children under-five, family empowerment interventions with the principle of involving families in care, and increasing family knowledge and skills in caring for sick children can be implemented as an effort to optimize care for sick toddlers.ConclusionThe results of this literature review can be used as a basis for nursing interventions that require parental involvement in caring for sick children. Family empowerment programs that are planned and structured can be applied in the care of sick children at home or in the hospital.
Autonomy-Supportive Sexual Health Communication and Sexual Health Behaviors for Black and Latino MSM in the House Ball Community: Protocol for a Social Network Analysis and Exploratory Structural Equation Model
Authors: Smith Martez D. R. , Leblanc Natalie M. , Nelson LaRon E. , McMahon James M. 
Published: October 2022

ABSTRACTBackgroundBlack and Latino men who have sex with men (MSM) have the highest risk of HIV of any group in the U.S. Prevalence could be even higher among Black and Latino MSM belonging to the House Ball Community (HBC), an understudied community comprised primarily of Black and Latino sexual and gender minorities, with HIV prevalence from non-probability samples ranging from 4% to 38%.ObjectivesBasic Psychological Needs Theory will be utilized to understand how sexual health communication (SHC) influences sexual health behaviors of HBC-MSM. The proposed study will advance this goal by describing characteristics of SHC embedded within social and sexual networks, and identifying the effects of SHC on sexual health behaviors among a sample of Black and Latino HBC-MSM.MethodsThis study entails cross-sectional quantitative survey design with internet-based data collection to test a theory-driven model of the effects of autonomy supportive communication on sexual health behaviors. Respondent-driven sampling (RDS) and internet driven sampling (ID) will be used to recruit a sample of 200 HBC-MSM. We will utilize egocentric network analysis to describe (a) the HBC-specific social and/or sexual network members who provide SHC; (b) the degree of autonomy support provided by network members, and (c) the sexual health behaviors characterizing the sample of HBC-MSM. Structural equation modeling (SEM) will be performed to test associations between autonomy supportive sexual health communication (independent variable) and sexual health behaviors (outcome), with needs satisfaction and intrinsic motivation as intervening mediators.DiscussionSuch knowledge is necessary to expand understanding of how SHC impacts sexual health behaviors for HBC-MSM. The study provides an critical perspective on sexual health behaviors and motivations as participants operate in HBC. Knowledge generated from this study will help improve current HIV prevention interventions, as well as inform the development of future interventions, tailored to HBC-MSM.Trial registrationN/A
Considerations for ensuring safety during telerehabilitation of people with stroke. A protocol for a scoping review
Authors: Gutierrez-Arias Ruvistay , González-Mondaca Camila , Marinkovic-Riffo Vinka , Ortiz-Puebla Marietta , Paillán-Reyes Fernanda , Seron Pamela 
Published: October 2022

AbstractIntroductionExercise interventions have a positive impact on people with stroke. However, access to exercise interventions is variable, and there may be a delay in the start of rehabilitation. Telerehabilitation has enabled the delivery of exercise interventions replacing the traditional face-to-face approach. Aspects related to the safety of people with stroke should be considered to avoid adverse events during the delivery of exercise interventions remotely. However, such information is scattered in the literature, and the detail with which measures taken during the implementation of exercise interventions for people with stroke are reported is unknown.ObjectiveTo summarise measures or aspects targeted at reducing the incidence of adverse events during the delivery of exercise interventions through telerehabilitation in patients after stroke.Materials and methodsA scoping review will be conducted. A systematic search in MEDLINE-Ovid, Embase-Ovid CENTRAL, CINAHL Complete (EBSCOhost), and other resources will be carried out. We will include primary studies, published in full text in any language, involving people with stroke who undergo telerehabilitation where exercise is the main component. Two reviewers will independently select studies and extract data, and disagreements will be resolved by consensus or a third reviewer. The results will be reported in a narrative form, using tables and figures to support them.DiscussionTo implement this strategy within rehabilitation services, one of the first aspects to be solved is to ensure the safety of people. The results of this scoping review could contribute an information base for clinicians and decision-makers when designing remotely delivered exercise intervention programs.Registration numberINPLASY202290104.
Treating intrusive memories after trauma in healthcare workers: a Bayesian adaptive randomised trial developing an imagery-competing task intervention
Authors: Ramineni Varsha , Millroth Philip , Iyadurai Lalitha , Jaki Thomas , Kingslake Jonathan , Highfield Julie , Summers Charlotte , Bonsall Michael B. , Holmes Emily A. 
Published: October 2022

ABSTRACTIntensive care unit (ICU) staff continue to face recurrent work-related traumatic events throughout the COVID-19 pandemic. Intrusive memories (IMs) of such traumatic events comprise sensory image-based memories. Harnessing research on preventing IMs with a novel behavioural intervention on the day of trauma, here we take critical next steps in developing this approach as a treatment for ICU staff who are already experiencing IMs days, weeks, or months post-trauma. To address the urgent need to develop novel mental health interventions, we used Bayesian statistical approaches to optimise a brief imagery-competing task intervention to reduce the number of IMs. We evaluated a digitised version of the intervention for remote, scalable delivery. We conducted a two-arm, parallel-group, randomised, adaptive Bayesian optimisation trial. Eligible participants worked clinically in a UK NHS ICU during the pandemic, experienced at least one work-related traumatic event, and at least three IMs in the week prior to recruitment. Participants were randomised to receive immediate or delayed (after four weeks) access to the intervention.Primary outcome was the number of IMs of trauma during week 4, controlling for baseline week. Analyses were conducted on an intention-to-treat basis as a between-group comparison. Prior to final analysis, sequential Bayesian analyses were conducted (n=20,23,29,37,41,45) to inform early stopping of the trial prior to the planned maximum recruitment (n=150). Final analysis (n=75) showed strong evidence for a positive treatment effect (Bayes factor, BF=1.25 × 106): the immediate arm reported fewer IMs (median=1, IQR=0-3) than the delayed arm (median=10, IQR=6-16.5). With further digital enhancements, the intervention (n=28) also showed a positive treatment effect (BF=7.31). Sequential Bayesian analyses provided evidence for reducing IMs of work-related trauma for healthcare workers. This methodology also allowed us to rule out negative effects early, reduced the planned maximum sample size, and allowed evaluation of enhancements. Trial RegistrationNCT04992390(www.clinicaltrials.gov).
Factors associated with persistent hypertension one year postpartum in persons with gestational hypertension or preeclampsia
Authors: Livergood M Christine , Mahlum Leigh , Hauck Jordan , Tallmadge Maggie , Hoppe Kara , Palatnik Anna 
Published: October 2022

AbstractObjectiveTo identify factors associated with persistent hypertension one-year postpartum after pregnancy complicated by gestational hypertension or preeclampsia.Study DesignA retrospective case-control study of postpartum patients who had a diagnosis of gestation hypertension or preeclampsia during a recent pregnancy and attended one-year postpartum annual exam and blood pressure check between 2014 and 2019 in a single academic medical center. Cases were defined as persons with persistent hypertension one year postpartum, using the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guidelines, defining stage I hypertension as systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥80 mmHg. Controls were defined as non-pregnant persons with normal blood pressure (BP) at one year postpartum. Using bivariate and multivariate analyses, demographic, clinical and labor characteristics were compared between persons who had persistent hypertension one-year postpartum and controls.ResultsOf the 595 persons included in this analysis, 268 (45.0%) had persistent hypertension one year postpartum. Bivariate analyses demonstrated that older maternal age, higher body mass index (BMI) at first prenatal visit, at delivery, and one year postpartum, mild-range BP (compared to normal BP) prior to discharge, and patients with elevated BP at 6-week postpartum visit, were more likely to have persistent hypertension one-year postpartum. In contrast, nulliparity was associated with lower risk of having persistent hypertension at one-year postpartum. Multivariate logistic regression demonstrated that mild range BP prior to discharge (aOR 1.78, 95%CI 1.16-2.72), elevated BPs at 6 weeks postpartum (aOR 2.01, 95% CI 1.36-3.00), and higher BMI at one-year postpartum (aOR 1.07, 95%CI 1.00-1.14), remained to be significantly associated with higher odds of persistent hypertension one-year postpartum, while nulliparity remained to be associated with lower odds of persistent hypertension one-year postpartum (aOR 0.55, 95%CI 0.36-0.84)ConclusionIn this cohort, 45% of patients with gestational hypertension or preeclampsia had persistent hypertension one-year postpartum by the 2017 ACC/AHA hypertension definition. Patients that had mildly elevated BPs in the immediate postpartum period as well as at 6 weeks postpartum, and higher BMI one year postpartum, had higher risk of having at least stage I HTN one year following pregnancy complicated by gestational hypertension or preeclampsia.
Efficacy and safety of endocrine therapy after mastectomy in patients with hormone receptor positive breast ductal carcinoma in situ:retrospective cohort study
Authors: Niu Nan , Zhang Yinan , Bai Yang , Wang Xin , Yan Shunchao , Song Dong , Xu Hong , Liu Tong , Hua Bin , Zhang Yingchao , Liu Jinchi , Qiao Xinbo , Liu Jiaxiang , Zheng Xinyu , Cao Hongyi , Liu Caigang 
Published: October 2022

AbstractBackgroundMore than half of Chinese patients with hormone receptor positive (HR+) ductal carcinoma in situ (DCIS) are treated with mastectomy, and usually followed by endocrine therapy (ET). Given that long-term ET can cause severe adverse effects it is important to determine the beneficial effect and safety of adjuvant ET after mastectomy on the disease-free survival (DFS) and adverse events in patients with HR+ DCIS.MethodsTo explore beneficial effect and safety of ET after mastectomy in patients with HR+ DCIS, we performed a multicenter, population-based study. This retrospective study analyzed the DFS and adverse events in 1037 HR+ DCIS Chinese patients with or without post-mastectomy ET from eight Breast Centers between 2006-2016. The median follow-up time was 86 months.ResultsThere were 791 DCIS patients receiving ET (ET group). Those patients were followed-up for a median of 86 months (range, 60-177 months). There were 23 cases with tumor recurrence or distant metastasis. There were similar 5-year DFS rates and DFS between the ET and non-ET groups, even for those with high risk factors. Conversely, 37.04% of patients suffered from adverse events after ET, which were significantly higher than those in the non-ET group.ConclusionET after mastectomy did not benefit patients with HR+ DCIS for their DFS, rather increased adverse events in those patients. Therefore, ET after mastectomy may not be recommended for patients with HR+ DCIS, even for those with high-risk factors, such as multifocal, microinvasive and higher T stage.FundingThis study was supported by grants from Outstanding Scientific Fund of Shengjing Hospital (201803) and Outstanding Young Scholars of Liaoning Province (2019-YQ-10).
Long COVID Risk and Pre-COVID Vaccination: An EHR-Based Cohort Study from the RECOVER Program
Authors: Brannock M Daniel , Chew Robert F , Preiss Alexander J , Hadley Emily C , McMurry Julie A , Leese Peter J , Girvin Andrew T , Crosskey Miles , Zhou Andrea G , Moffitt Richard A , Funk Michele Jonsson , Pfaff Emily R , Haendel Melissa A , Chute Christopher G ,   the N3C and RECOVER Consortia
Published: October 2022

AbstractImportanceCharacterizing the effect of vaccination on long COVID allows for better healthcare recommendations.ObjectiveTo determine if, and to what degree, vaccination prior to COVID-19 is associated with eventual long COVID onset, among those a documented COVID-19 infection.Design, Settings, and ParticipantsRetrospective cohort study of adults with evidence of COVID-19 between August 1, 2021 and January 31, 2022 based on electronic health records from eleven healthcare institutions taking part in the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative, a project of the National Covid Cohort Collaborative (N3C).ExposuresPre-COVID-19 receipt of a complete vaccine series versus no pre-COVID-19 vaccination.Main Outcomes and MeasuresTwo approaches to the identification of long COVID were used. In the clinical diagnosis cohort (n=47,752), ICD-10 diagnosis codes or evidence of a healthcare encounter at a long COVID clinic were used. In the model-based cohort (n=199,498), a computable phenotype was used. The association between pre-COVID vaccination and long COVID was estimated using IPTW-adjusted logistic regression and Cox proportional hazards.ResultsIn both cohorts, when adjusting for demographics and medical history, pre-COVID vaccination was associated with a reduced risk of long COVID (clinic-based cohort: HR, 0.66; 95% CI, 0.55-0.80; OR, 0.69; 95% CI, 0.59-0.82; model-based cohort: HR, 0.62; 95% CI, 0.56-0.69; OR, 0.70; 95% CI, 0.65-0.75).Conclusions and RelevanceLong COVID has become a central concern for public health experts. Prior studies have considered the effect of vaccination on the prevalence of future long COVID symptoms, but ours is the first to thoroughly characterize the association between vaccination and clinically diagnosed or computationally derived long COVID. Our results bolster the growing consensus that vaccines retain protective effects against long COVID even in breakthrough infections.Key PointsQuestionDoes vaccination prior to COVID-19 onset change the risk of long COVID diagnosis?FindingsFour observational analyses of EHRs showed a statistically significant reduction in long COVID risk associated with pre-COVID vaccination (first cohort: HR, 0.66; 95% CI, 0.55-0.80; OR, 0.69; 95% CI, 0.59-0.82; second cohort: HR, 0.62; 95% CI, 0.56-0.69; OR, 0.70; 95% CI, 0.65-0.75).MeaningVaccination prior to COVID onset has a protective association with long COVID even in the case of breakthrough infections.
IL-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis
Authors: Kotas Maya E. , Patel Neil N. , Cope Emily K. , Gurrola Jose G. , Goldberg Andrew N. , Pletcher Steven D. , Seibold Max A. , Moore Camille M. , Gordon Erin D. 
Published: October 2022

AbstractBackgroundEpithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell type shifts and their relationship to CRS endotypes and severity are incompletely described.ObjectiveThe purpose of this study was to understand the relationship of epithelial cell remodeling to inflammatory endotypes and disease outcomes in CRS.MethodsUsing cell type transcriptional signatures derived from epithelial single cell sequencing, we analyzed bulk RNA sequencing data from sinus epithelial brushes obtained from patients with CRS with and without nasal polyps in comparison to healthy controls.ResultsThe airway epithelium in nasal polyposis displayed increased tuft cell transcripts and decreased ciliated cell transcripts along with an IL-13 activation signature. In contrast, chronic rhinosinusitis without polyps showed an IL-17 activation signature. IL-13 activation scores were associated with increased tuft cell, goblet cell and mast cell scores and decreased ciliated cell scores. Furthermore, the IL-13 score was strongly associated with a previously reported activated (“polyp”) tuft cell score and a prostaglandin E2 (PGE2) activation signature. The Lund-McKay score, a computed tomographic metric of sinus opacification, correlated positively with activated tuft cell, mast cell, PGE2, and IL-13 and negatively with ciliated cell transcriptional signatures.ConclusionsThese results demonstrate that cell type alterations and PGE2 stimulation are key components of IL-13 induced epithelial remodeling in nasal polyposis, while IL-17 signaling is more prominent in CRS without polyps, and that clinical severity correlates with the degree of IL-13 induced epithelial remodeling.Key MessagesCell type signatures from single cell RNA sequencing, applied to bulk sequenced RNA sinus brushes, suggest increased tuft cells and mast cells and decreased ciliated cells in nasal polyp epithelium.IL-17 signaling rather than IL-13 signaling is observed in epithelium from CRSsNP.IL-13-drives epithelial remodeling and prostaglandin E2 signatures correlated with clinical measures of sinus opacification in CRS.Capsule SummaryMeasures of epithelial remodeling, including both IL-13 and PGE2 induced epithelial activation and cell type specific transcript alterations, correlate with a radiographic metric of disease severity in CRSwNP.
Changes in Fentanyl Distribution in California
Authors: Dugan Miah V. , Shah Ali H. , Anthony Trinidy R. , Famosa Rafiat , Piper Brian J. 
Published: October 2022

AbstractBackgroundFentanyl is a synthetic opioid that is commonly given as a medication to alleviate pain. This drug can be administered through multiple routes, hence making it easy to exploit at high rates. Due to the flexibility in which it can be taken, it increases the ease of both access and use. The purpose of this study was to analyze trends in the distribution of fentanyl and its formulations across Medicaid enrollees in California and among the 3-digit registrant zip codes in California over the period of pre-pandemic (2018–2019) to the early stages of the COVID-19 pandemic (2020).MethodsUsing the Automated Reports and Consolidated Ordering System (ARCOS), the distribution of fentanyl across California was compiled from 2018 to 2020. Utilizing ARCOS, the number of individuals within the source population who lived in one of California’s many zip codes was observed. To analyze the fentanyl distribution trend, we used Google Sheets, GraphPad Prism (Version 9.3.0 [463]), and Microsoft 365 Excel. These were helpful to organize the Medicaid, ARCOS data, and as well as to create graphs. The Medicaid database was used to compile the number of fentanyl formulations prescribed from 2018 to 2020 across California.ResultsThe analyses from both databases provided insight into the difference in fentanyl distribution in California from the years 2018 to 2020. After looking further into the many 3-digit registrant zip codes as well as Medicaid enrollees, it was found that there was a decrease in the distribution of fentanyl and its formulations. Additionally, it was found that the distribution of fentanyl as a medication by business activities also decreased from 2018 to 2020.ConclusionThe results indicate that there was more fentanyl being distributed and prescribed before the pandemic (2018– 2019). On the other hand, when we considered the effects of the pandemic, during 2020, there was quite a drastic decrease in the amount of fentanyl being prescribed and distributed to those living in California and those enrolled in Medicaid.
Copy number variation onABCC2-DNMBP lociimpacts the diversity and composition of the gut microbiota in pigs
Authors: Ramayo-Caldas Yuliaxis , Crespo-Piazuelo Daniel , Morata Jordi , González-Rodríguez Olga , Sebastià Cristina , Castello Anna , Dalmau Antoni , Ramos-Onsins Sebastian , Alexiou Konstantinos G. , Folch Josep M. , Quintanilla Raquel , Ballester Maria 
Published: October 2022

AbstractBackgroundGenetic variation in the pig genome partially modulates the composition of porcine gut microbial communities. Previous studies have been focused on the association between single nucleotide polymorphisms (SNPs) and the gut microbiota, but little is known about the relationship between structural variants and gut microbial traits.ResultsThe main goal of this study was to assess the effect of porcine genome copy number variants (CNVs) on the diversity and composition of pig gut microbiota. For this purpose, we used whole-genome sequencing data to undertake a comprehensive identification of CNVs followed by a genome-wide association analysis between the estimated CNV status and the gut bacterial diversity in a commercial Duroc pig population. A CNV predicted as gain (DUP) partially harboringABCC2-DNMBP lociwas associated with richness (p-value=5.41×10−5) and Shannon α-diversity (p-value=1.42×10−4). Thein-silicopredicted gain of copies was validated by real-time quantitative PCR (qPCR), and its segregation, and positive association with the richness and Shannon α-diversity of the porcine gut bacterial ecosystem was confirmed in an unrelated F1 (Duroc×Iberian) cross. Furthermore, despite genetic and environmental differences between both populations, the gut microbiota of DUP samples showed a significant over-abundance of theDesulfovibrio, Blautia, Phascolarctobacterium, Faecalibacterium, SuccinivibrioandAnaerovibriogenera.ConclusionsIn summary, this is the first study that evaluate the putative modulatory role of CNVs on pig gut microbiota. Our results advice the relevance of considering the role of host-genome structural variants as modulators of microbial ecosystems, and suggest theABCC2-DNMBPCNV as a host-genetic factor for the modulation of the diversity and composition of the gut microbiota in pigs.