bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salivary duct carcinoma: A report of 70 FNA cases and review of the literature
Authors: Wakely Paul E. 
Published: March 2022

BACKGROUNDAlthough usually recognized as malignant, fine‐needle aspiration (FNA) biopsy of salivary duct carcinoma (SDC) has been confused with other primary salivary gland (SG) neoplasms. This article undertook an analysis of a large collection of SDC FNA cases to assess diagnostic accuracy, specificity, and cytopathology.METHODSCytopathology files were searched for SDC with histopathologic validation. FNA biopsy smears were performed using standard techniques.RESULTSSeventy cases from 56 patients (M:F, 1.9:1; age range, 26‐92 years; mean age, 65 years) met inclusion criteria. All had tissue confirmation of SDC. FNA sites included: parotid gland (42, 60% cases), neck (10), submandibular gland (7), pre‐/post‐auricular area (5), face/cheek (3), mediastinal lymph nodes (2), and clavicle (1). Aspirates were from primary (52, 74%), metastatic (12, 17%), and locally recurrent (6, 9%) neoplasms. FNA diagnoses included: SDC (19, 27%), favor/suspicious for SDC (7, 10%), high‐grade carcinoma (11), adenocarcinoma (9), carcinoma (6), malignant (6), SG neoplasm (5), atypia (3), SDC versus another malignancy (2), and pleomorphic adenoma (2). Large polygonal cells in groups and single forms showed cribriforming, variable necrosis, pseudopapillae, and oncocytic change. Androgen receptor staining was positive in all cases.CONCLUSIONSFNA biopsy is accurate and reliable in classifying SDC as a malignant neoplasm, but much less so for identification as a specific tumor type. Using the Milan system, 86% of aspirates were classified as either malignant or suspicious for malignancy. A recurring pitfall includes sampling error in cases of SDC ex pleomorphic adenoma.;
In Vivo Modeling of Tumor Heterogeneity for Immuno‐Oncology Studies: Failures, Improvements, and Hopes
Authors: DiMarco Ashley V. , Maddalo Danilo 
Published: March 2022

AbstractMurine tumor modeling is fundamental for the preclinical development of anti‐cancer therapies. Use of immunocompetent mouse models is becoming increasingly relevant as we gain more knowledge of how cancer cells interact with the immune system in the tumor microenvironment and how we can harness the immune system to fight tumors. However, there are few intrinsically immunogenic preclinical tumor models, and the vast majority either do not respond to therapy or do not faithfully predict the responses of the therapy when applied in the clinic. Here, we discuss the limitations of commonly used murine tumor models in immuno‐oncology and strategies to improve their immunogenicity and mutational burden to more accurately reflect the heterogeneity of patient tumors. © 2022 Wiley Periodicals LLC.
A 60‐GHz low‐noise amplifier with +7.258‐dBm third‐order input intercept point using current reuse feedforward distortion cancellation for 5G emerging communication
Authors: Veerasamy Thenmozhi , Manickam Bhaskar 
Published: March 2022

AbstractIn the ever‐growing 5G technology, the millimetre‐wave (mmWave) frequency spectrum is the inevitable mainstream for high‐speed wireless communication. The wide‐ranging spectrum bandwidth of the mmWave frequency attracts interest in radio frequency (RF) front‐end design which will be very much beneficial for security and cellular‐based applications such as intersatellite communication and automotive vehicle‐to‐vehicle communication. The RF front end requires low‐power and low‐noise receiver architecture for effective satellite communication, and it needs high throughput with maximum data transfer for cellular‐based applications. To address these challenges, this paper presents a novel low‐noise amplifier (LNA) operating from 57.12‐ to 66.25‐GHz frequency. The design is implemented using UMC 65‐nm CMOS process technology, and the post‐layout simulations are carried out using the Cadence Spectre RF tool. At 60 GHz, the LNA exhibits a power gain of 15.46 dB, minimum noise figure (NF) of 1.32 dB while consuming 6.59 mW from a 1.2‐V supply. The LNA employs the current reuse feedforward distortion cancelation technique to improve the third‐order input intercept point (IIP3) to +7.258 dBm. The proposed LNA provides a relatively better figure of merit compared to some of the recently proposed mmWave LNA architectures.
CPHEN‐013: Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver
Authors: Vanuytsel Kim , Yeung Anthony K. , Dowrey Todd W. , Murphy George J. , Belkina Anna C. 
Published: March 2022

AbstractHematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy and can give rise to all the mature blood cell types in our body, while at the same time maintaining a pool of HSCs through self‐renewing divisions. This potential is reflected in their functional definition as cells that are capable of long‐term multi‐lineage engraftment upon transplantation. While all HSCs meet these criteria, subtle differences exist between developmentally different populations of these cells. Here we present a comprehensive overview of traditional and more recently described markers for phenotyping HSCs and their downstream progeny. To address the need to assess the growing number of surface molecules expressed in various HSC‐enriched fractions at different developmental stages, we have developed an extensive multi‐parameter spectral flow cytometry panel to phenotype hematopoietic stem and multipotent progenitor cells (HSC/MPPs) throughout development. In this study we then employ this panel to comprehensively profile the HSC compartment in the human fetal liver (FL), which is endowed with superior engraftment potential compared to postnatal sources. Spectral cytometry lends an improved resolution of marker expression to our comprehensive approach, allowing to extract combinatorial expression signatures of several relevant HSC/MPP markers to precisely characterize the HSC/MPP fraction in a variety of tissues.
Stoichiometric mismatch causes a warming‐induced regime shift in experimental plankton communities
Authors: Diehl Sebastian , Berger Stella A. , Uszko Wojciech , Stibor Herwig 
Published: March 2022

AbstractIn many ecosystems, consumers respond to warming differently than their resources, sometimes leading to temporal mismatches between seasonal maxima in consumer demand and resource availability. A potentially equally pervasive, but less acknowledged threat to the temporal coherence of consumer‐resource interactions is mismatch in food quality. Many plant and algal communities respond to warming with shifts toward more carbon‐rich species and growth forms, thereby diluting essential elements in their biomass and intensifying the stoichiometric mismatch with herbivore nutrient requirements. Here we report on a mesocosm experiment on the spring succession of an assembled plankton community in which we manipulated temperature (ambient vs. +3.6°C) and presence versus absence of two types of grazers (ciliates and Daphnia), and where warming caused a dramatic regime shift that coincided with extreme stoichiometric mismatch. At ambient temperatures, a typical spring succession developed, where a moderate bloom of nutritionally adequate phytoplankton was grazed down to a clear‐water phase by a developing Daphnia population. While warming accelerated initial Daphnia population growth, it speeded up algal growth rates even more, triggering a massive phytoplankton bloom of poor food quality. Consistent with the predictions of a stoichiometric producer–grazer model, accelerated phytoplankton growth promoted the emergence of an alternative system attractor, where the extremely low phosphorus content of the abundant algal food eventually drove Daphnia to extinction. Where present, ciliates slowed down the phytoplankton bloom and the deterioration of its nutritional value, but this only delayed the regime shift. Eventually, phytoplankton also grew out of grazer control in the presence of ciliates, and the Daphnia population crashed. To our knowledge, the experiment is the first empirical demonstration of the “paradox of energy enrichment” (grazer starvation in an abundance of energy‐rich but nutritionally imbalanced food) in a multispecies phytoplankton community. More generally, our results support the notion that warming can exacerbate the stoichiometric mismatch at the plant–herbivore interface and limit energy transfer to higher trophic levels.
Competitive size asymmetry, not intensity, is linked to species loss and gain in a native grassland community
Authors: Brown Charlotte , Cahill James F. 
Published: March 2022

AbstractCompetition is often highlighted as a major force influencing plant species diversity. However, there are multiple facets of competition (e.g., strength, intransitivity, and size asymmetry) that may have independent and differential impacts on diversity, making understanding the degree to which competition structures communities difficult. Unfortunately, field‐based experiments that decouple multiple facets of competition are lacking, limiting our ability to test theoretical frameworks and reducing understanding of the actual linkages among competition and coexistence. Here, we experimentally manipulate the size structure of local grassland communities to examine the relative impacts of competitive size asymmetry (i.e., competitive advantage based on relative size) and intensity (i.e., mean effect of neighbors on plant growth) on species loss and gain. Increased competitive size asymmetry was associated with increased species loss and decreased species gain, while no relationship was found between competitive intensity and species loss and gain. Furthermore, the probability of loss was not dependent on a species initial size, suggesting that small species may not always be the losers of size‐asymmetric interactions. Instead, loss was dependent on species rarity, where loss was higher for rare species. Overall, these results suggest that competitive size asymmetry may be more important for species loss than intensity in some plant communities and demonstrates the importance of decoupling different aspects of competition to better understand their drivers and ecological consequences.
Confronting spatial capture–recapture models with realistic animal movement simulations
Authors: Theng Meryl , Milleret Cyril , Bracis Chloe , Cassey Phillip , Delean Steven 
Published: March 2022

AbstractSpatial capture–recapture (SCR) models have emerged as a robust method to estimate the population density of mobile animals. However, model evaluation has generally been based on data simulated from simplified representations of animal space use. Here, we generated data from animal movement simulated from a mechanistic individual‐based model, in which movement emerges from the individual's response to a changing environment (i.e., from the bottom‐up), driven by key ecological processes (e.g., resource memory and territoriality). We drew individual detection data from simulated movement trajectories and fitted detection data sets to a basic, resource selection and transience SCR model, as well as their variants accounting for resource‐driven heterogeneity in density and detectability. Across all SCR models, abundance estimates were robust to multiple, but low‐degree violations of the specified movement processes (e.g., resource selection). SCR models also successfully captured the positive effect of resource quality on density. However, covariate models failed to capture the finer scale effect of resource quality on detectability and space use, which may be a consequence of the low temporal resolution of SCR data sets and/or model misspecification. We show that home‐range size is challenging to infer from the scale parameter alone, compounded by reliance on conventional measures of “true” home‐range size that are highly sensitive to sampling regime. Additionally, we found the transience model challenging to fit, probably due to data sparsity and violation of the assumption of normally distributed inter‐occasion movement of activity centers, suggesting that further development of the model is required for general applicability. Our results showed that further integration of complex movement into SCR models may not be necessary for population estimates of abundance when the level of individual heterogeneity induced by the underlying movement process is low, but appears warranted in terms of accurately revealing finer scale patterns of ecological and movement processes. Further investigation into whether this holds true in populations with other types of realistic movement characteristics is merited. Our study provides a framework to generate realistic SCR data sets to develop and evaluate more complex movement processes in SCR models.
Stabilization of resistive wall mode and improved plasma performance in a low‐aspect‐ratio reversed field pinch by a single mode control power supply system
Authors: Nagano Tomoyuki , Sanpei Akio , Masamune Sadao 
Published: March 2022

AbstractStabilization of resistive wall modes (RWMs) is one of the important issues in magnetic fusion research. In the reversed field pinch (RFP), the number of unstable RWMs becomes smaller by lowering the aspect ratio (A), the ratio of the minor to major radius of the device. In REversed field pinch of Low‐Aspect ratio eXperiment (RELAX), whose aspect ratio is 2, unstable m/n = 1/2 RWM was stabilized by a single mode control power supply system with improvements of discharge performance. In this paper we report new results with modified power supply system in which magnetic boundary condition near the poloidal gaps is controlled. The modified power supply system is designed to stabilize the most unstable m/n = 1/2 mode by use of the saddle coil array covering the whole torus with eight (8) power supplies. The results show that the discharge duration is improved from ~ 3.0 ms to ~ 4.0 ms, limited by the capability of the iron core in RELAX device. Stabilization of the dominant RWM with the resultant improved plasma performance by a single mode control power supply system shows one of the advantages of a low‐aspect‐ratio RFP concepts.
Energy and spectral efficient resource allocation in 5G HetNet using optimized deep bi‐BRLSTM model
Authors: Tejasvi T. R. , Manjaiah D. H. 
Published: March 2022

AbstractThe heterogeneous deployment of ultra‐dense femto cell dispenses an enhanced coverage and capacity for the users in the 5G wireless communication system. Due to the substantial growth in wireless data traffic and the inflation of energy consumption, the design of energy and spectrum efficient wireless network is seems to be an extreme concern. Therefore, there is a need to develop an energy and spectrum efficient resource allocation model. The joint contribution of the maximization of energy efficiency (EE) and spectral efficiency (SE) with its constraints is formulated as a multiobjective optimization problem. The resource allocation (RA) issue in the network is handled by the hybrid deep bidirectional battle royale long short term memory (Deep bi‐BRLSTM) model. The loss function in the network model is taken as a consideration to optimize the SE and EE. Fuzzy based energy efficient adaptive atom search optimizer (FEEAAS) is instigated to optimize the trade‐off of EE and SE consecutively. It is embedded with high convergence rate with maximum efficiency which is suitable for power optimization with maximum resource allocation. The performance of the proposed model is implemented in Matlab Simulink platform. The simulation result reveals that the presented model attains an optimal trade‐off between the EE and SE and also improves the overall throughput and delay when compared with existing solutions.
Recent advances in nanomaterial‐assisted electrochemical sensors for food safety analysis
Authors: Gu Ying , Li Yonghui , Ren Dabing , Sun Liping , Zhuang Yongliang , Yi Lunzhao , Wang Shuo 
Published: March 2022

AbstractFood safety as a public health issue has aroused worldwide concern. Food safety risks caused by the existence of food safety hazards in food may occur in all stages of the food supply chain. Thus, great emphasis is placed on sensitive, selective, and convenient analytical methods of various food safety hazards in food. At present, nanomaterials are at the forefront of various electrochemical sensing applications. Given their unique physical, chemical, and biological characteristics, nanomaterials are considered perfect candidates for the design of electrode surface to construct electrochemical sensors with excellent analytical performance. With the assistance of nanomaterials, electrochemical sensors are a potential alternative to conventional methods of food safety analysis. This review focuses on current research achievements of nanomaterial‐assisted electrochemical sensors for food safety analysis reported in recent 5 years. It highlights the different detection mechanisms for analytes, flexible sensing strategies based on nanomaterials, and portable miniaturized electrochemical devices. Finally, the challenges and limitations in the design of electrochemical sensors for food safety analysis are also discussed.
Viral wheezing in early childhood as a risk factor for asthma in young adulthood: A prospective long‐term cohort study
Authors: Heikkilä Paula , Korppi Matti , Ruotsalainen Marja , Backman Katri 
Published: March 2022

AbstractBackground and AimsThere is an increased risk of asthma after viral wheezing episodes in early childhood, but unfortunately, prospective longitudinal data until adulthood are mostly lacking. The aim of this cohort study was to evaluate the risk of asthma in young adulthood after hospitalization for viral wheezing episodes in early childhood.MethodsThe original cohort comprised 100 individuals aged <24 months who were hospitalized for viral wheezing episodes in 1992–1993. After the index episode, data on a diagnosis of asthma 1 year later and at median ages of 4.0, 7.2, and 12.3 years were recorded in follow‐up visits. Forty‐nine individuals attended the latest follow‐up visit at the age of 17–20 years. Current asthma was diagnosed based on symptoms at the time of the last follow‐up, use of inhaled corticosteroids and peak expiratory flow monitoring.ResultsA total of 26 (53%) of the 49 cohort individuals had asthma at a mean age of 18.8 years. In multivariate analyses, a diagnosis of asthma 1 year after index hospitalization and at ages 4.0, 7.2, and 12.3 years were significant risk factors for current asthma (adjusted odds ratios [aORs] of 7.13, 8.86, 8.05, and 21.16, respectively). Atopic dermatitis in infancy (aOR: 4.20) and eosinophilia on admission (5.18) were also significant predictive factors for asthma.ConclusionOver half (26/49) of the participants who had been hospitalized for viral wheezing episodes in early childhood had asthma in young adulthood. An asthma diagnosis at any age during childhood, as well as eosinophilia in early childhood, were independent significant predictive factors for asthma.
Predicting the effectiveness of interventions on population‐level sodium reduction: A simulation modeling study
Authors: Zeng Yiping , Xu Zeshui , Rao Yu 
Published: March 2022

AbstractBackground and AimsInterventions that significantly reduce dietary sodium intake are anticipated to decrease gastric cancer (GCa) burden. However, the optimal restriction strategies remain unknown at present. This study aims to understand where and to what extent policies modifying sodium consumption change the distribution of GCa burden, and the effects of potential salt reduction strategies in China.MethodsThe synthetic population in this microscopic simulation study is close to reality. We incorporated estimates of dietary patterns and GCa risk into the model of excess salt consumption. These estimates and simulated population were obtained from the China Health and Nutrition Survey, Global Burden of Disease Project, and the sixth census of China's National Bureau of Statistics, respectively.ResultsIn the no intervention scenario, we estimated that disease burdens due to excess sodium intake would be at 472.9 million disability‐adjusted life years (DALYs) nationally between 2010 and 2030 (95% credible interval [CrI]: 371.1–567.7). The GCa burden caused by high sodium is projected to have a disproportionate impact on the central and southern provinces of China (9.2 and 4.5 million DALYs, respectively). Implementing a cooking salt substitute strategy would be expected to avoid a larger portion of GCa burden (about 67.2%, 95% CrI: 66.8%–67.6%) than the salt‐restriction spoon program (about 16.7%, 95% CrI: 16.1%–17.4%).ConclusionDietary salt reduction policy is very powerfully effective in reducing the GCa burden overall. It is expected that proposed salt substitutes are more effective than traditional salt‐restriction spoons to avoid increased inequality.
Newspaper reporting of suicide in Nepal: Quality assessment against World Health Organization media guidelines
Authors: Singh Rakesh , Mahato Sharika , Khadka Seema , Basnet Pragyan , Bista Kalendra , Karki Ritika , Arafat S. M. Yasir 
Published: March 2022

AbstractBackgroundSensible media reporting of suicide is a population‐based suicide prevention strategy. However, the quality of media reporting of suicide has not been assessed in Nepal.ObjectivesWe aimed to assess the newspaper reporting status of suicide in Nepal with reference to World Health Organization (WHO) media guidelines for suicide reporting.MethodWe retrospectively searched eight major newspapers in Nepal between January 2020 and May 2021 and assessed 167 news reports against WHO suicide reporting guidelines.ResultsPotentially harmful characteristics were found to be reported in both the title and main text of the reports. About half of them mentioned sex (48.5%) and 38.3% mentioned the location of suicide in the title. Of the 167 reports, 74.3%, 95.2%, 34.7%, 92.2%, 98.8%, and 52.7% mentioned the name, sex, occupation, method of suicide, the location of suicide, and life events, respectively, in their main content. On the other hand, only 6% and 2.4% of reports mentioned linkage of suicides with mental illness and substance abuse, respectively. While lesser than 1% of reports narrated educative information regarding suicide prevention, none mentioned contact information for help‐seeking for the vulnerable.ConclusionNewspaper reporting of suicide in Nepal poorly adheres to WHO guidelines, substantiated by the high presence of potentially harmful characteristics and negligible presence of potentially helpful characteristics.