bluuebunny/crossref_metadata_2025_split huggingface dataset:
Су-май қоспаларын бөлуге арналған ПЭТФ трек мембраналарды трихлороктилсиланмен гидрофобизациялау
Authors: Нармухамедова А. , Корольков И. , Жатканбаева Ж. , Муслимова И. , Мельникова Г. , Здоровец М. 
Published: May 2022

Мақалада трихлороктилсиланмен полиэтилентерефталатты (ПЭТФ) трек мембраналарының модификациясының оңтайлы жағдайлары зерттелді. Трихлороктилсиланның концентрациясына және реакция уақытына байланысты тректі мембрананың кеуек диаметрі мен шеткі сулану бұрышының өзгеру нәтижелері келтірілген. Концентрациясы 15 ммоль/л трихлороктилсиланмен 24 сағат бойы тректі мембрананы өндегенде мембрананың шеткі сулану бұрышының ең жоғары көрсеткіші (1000) анықталды.
Алынған үлгілердің құрамындағы өзгерістер ИҚ-Фурье спектроскопиясымен сипатталды және газ өткізгіштікке сыналды. Май, су және органикалық еріткіштерді сүзуде сынақ хлороформ мен о-ксилол үшін жоғары өнімділік көрсетті (91,96мл/с*м2 дейін), май үшін максималды өнімділік 5,81мл/с*м2 құрады, ал су түрлендірілген мембранадан мүлдем өтпеді.
Giant Fibrovascular Polyp – Amending Knowledge About a Rare Entity from a Known Benign to an Unknown Malignant Behavior
Authors: Dubey Anshita , Kaur Simarpreet , Chopra Shamit 
Published: May 2022

A giant fibrovascular polyp is a non-epithelial tumor of esophagus. It usually arises from the proximal esophagus behind the cricoid cartilage from the upper esophageal sphincter. These polyps were previously considered as benign non neoplastic intraluminal masses. However, with continuous studies and advanced testing by FISH (Fluorescence in situ hybridization) done in multiple cases worldwide, it has now been established that this entity is synonymous with well differentiated liposarcoma. Being proven to be a malignant entity now, care should be taken while treating such cases, as these will require an adequate resection margin during its surgical removal.
This case report aims at enlightening the treating clinicians along with reporting radiologists and pathologists about this rare entity and to emphasize on correct management for patients’ benefit as it is known for recurrence and dedifferentiation. Also, being a sarcomatous lesion, it may lead to local and distant spread and prove fatal to the patient.
Keywords: Giant fibrovascular polyp, liposarcoma, esophageal polyp
Geochemical Characteristics and Quality Appraisal of Groundwater From Huatugou of the Qaidam Basin on the Tibetan Plateau
Authors: Wang Shengbin , Xie Zhan , Wang Fenglin , Zhang Yuqing , Wang Wanping , Liu Kui , Qi Zexue , Zhao Fengyun , Zhang Guoqiang , Xiao Yong 
Published: May 2022

Groundwater is the foremost water resource for various purposes in arid regions. The extremely arid climate makes groundwater geochemistry there evolve faster in a short distance and water supply face higher pressure of poor geochemical quality. A hyper-arid watershed on the Tibetan Plateau was investigated to get insights into the geochemical signature, formation, and quality suitability of groundwater there. A total of 13 surface water samples and 32 phreatic groundwater samples were collected for hydrogeochemical analysis. The results showed groundwater had better hydrogeochemical quality than surface water and was more favorable for human society utilization. Groundwater was dominated by relatively fresh hydrochemical facies of HCO3–Ca, mixed HCO3–Na·Ca, and mixed Cl–Mg·Ca type with more than 93% of samples having the TDS below 1,000 mg/L. Most of the groundwaters were soft fresh water (84.38%) and had excellent to good quality (93%) for domestic purposes based on entropy-weighted water quality index evaluation. Groundwater was suitable for irrigation in terms of sodium and permeability hazard, but the potential salinity hazard should be concerned. The poor geochemical quality of groundwater was ascribed to the salinity caused by strong evaporation. Natural rock–water interactions including silicate weathering, carbonate dissolution, and cation exchange were still the predominated processes governing groundwater chemical composition. The influence of human activities was very limited. Groundwater resource exploitation and management should mainly consider the salinity and strong evaporation due to shallow water depth.
Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma
Authors: Zhang Zilong , Shang Jin , Dai Zonglin , Yao Yutong , Shi Ying , Zhong Deyuan , Liang Yuxin , Lai Chunyou , Yang Qinyan , Feng Tianhang , Huang Xiaolun 
Published: May 2022

Background: Pancreatic adenocarcinoma (PAAD) is among the most common types of cancer with a poor prognosis. Transmembrane protein 170B (TMEM170B) has been reported to suppress breast cancer proliferation, metastasis, and tumorigenesis and is related to prognosis. However, its role in PAAD and the underlying molecular mechanisms are yet to be investigated.Patients and methods: We performed a comprehensive analysis of RNA sequencing data obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases to determine TMEM170B expression. Immunostaining and real-time polymerase chain reaction (RT-PCR) were done to determine TMEM170B expression in human pancreatic cancer cell lines and tissue specimens. Furthermore, the correlation of TMEM170B with clinicopathological features and PAAD prognosis was investigated, and the mechanisms were explored through enrichment analysis and immune cell infiltration analysis.Results: TCGA and GEO dataset analysis revealed that TMEM170B expression in PAAD tissue samples was significantly lower than that in non-tumorous tissues, which was further confirmed by immunohistochemistry and RT-PCR. Low TMEM170B expression was associated with poor differentiation (p = 0.014). Multivariate analysis identified that TMEM170B is an independent indicator for overall survival [hazard ratio (HR) = 0.116, 95% confidence interval (CI) = 0.014–0.995; p = 0.049] and disease-free survival (HR = 0.19, 95% CI = 0.04–0.910; p = 0.038) in patients with PAAD. Additionally, TMEM170B was involved in immune-related gene sets, including those related to chemokine signaling pathways and innate and adaptive immunity. High TMEM170B expression was linked to antitumor immune microenvironment with a high infiltration of B cells, T cells, dendritic cells, monocytes, M1 macrophages, neutrophil, and natural killer cells and a low infiltration of Tregs and myeloid-derived suppressor cells (all p &lt; 0.05).Plain Language Summary: There is an urgent need to identify clinical prognostic biomarkers and targeted drugs for pancreatic cancer treatment. In this study, the expression status and prognostic value of transmembrane protein 170B (TMEM170B) in pancreatic adenocarcinoma were elucidated. Furthermore, TMEM170B, as a tumor suppressor gene, induced antitumor immune effects, including increased tumor infiltration of immune effector cells and reduced levels of inhibitory immune molecules and regulatory cells. Therefore, TMEM170B could be regarded as a novel target in preventing the progression of pancreatic cancer.Conclusion: The findings suggest that low TMEM170B expression is remarkably correlated with poor PAAD prognosis, which might provide a therapeutic target for PAAD.
A 1-Bit Coding Metasurface With Polarization Conversion in X-Band
Authors: Gao Wen Hua , Chen Mao , Cheng Qiang , Cui Tie Jun 
Published: May 2022

Polarization conversion metasurfaces are widely used in optical devices, microwave devices and communication systems, owing to their unique polarization modulation characteristics. However, in some applications (such as folded reflectarrays), the unit cell must be capable of polarization conversion and phase modulation. To the best of our knowledge, there are only a few related designs with both the functionalities. In this paper, we propose a well-performing 1-bit reconfigurable coding metasurface with polarization conversion. It realizes linear-to-linear polarization conversion in a 1.32 GHz bandwidth, and the conversion loss is within 1 dB. Simultaneously, the metasurface achieves a phase difference of approximately 180° by switching the working state of the PIN diodes. This metasurface has great potential for radar detection, folded reflectarrays, and other fields.
Survival Benefits for Pulmonary Adenocarcinoma With Malignant Pleural Effusion After Thoracoscopic Surgical Treatment: A Real-World Study
Authors: Li Xin , Li Mingbiao , Lv Jinshuang , Liu Jinghao , Dong Ming , Xia Chunqiu , Zhao Honglin , Xu Song , Wei Sen , Song Zuoqing , Chen Gang , Liu Hongyu , Chen Jun 
Published: May 2022

ObjectivesMalignant cells in the pleural fluid or pleural metastasis are classified as stage IV non-small cell lung cancer. Radical surgery is generally considered not suitable for such patients. The aim of our study was to discuss the effectiveness of video-assisted thoracoscopic surgery (VATS) in such patients.MethodsA retrospective analysis of the clinical records of 195 patients was performed. These patients were all diagnosed with locally advanced pulmonary adenocarcinomas with malignant pleural effusion (MPE, M1a) but no distant organ metastasis. The 195 patients included 96 patients who underwent VATS plus chemotherapy and 99 patients who received thoracic drainage plus chemotherapy. The baseline characteristics of the patients included age, gender, smoking history, Eastern Cooperative Oncology Group (ECOG) score, and number of chemotherapy cycles (2–4 cycles or &gt;4 cycles); we also analyzed clinical characteristics including the specific surgical options of the VATS group.ResultsIn multivariate analysis, when compared to the thoracic drainage group, the VATS group remained significantly associated with the overall survival [HR=0.480 (95%CI 0.301-0.765)]; when compared to the lobectomy, the sub-lobectomy and the palliative surgery, remained significantly associated with the overall survival [HR=0.637 (95%CI 0.409-0.993) and HR=0.548 (95%CI 0.435-0.832), respectively]. The median survival time (MST) of patients who underwent VATS (n = 96, 49.2%) was 25 months (95% CI 22.373–27.627) whereas the patients who received thoracic drainage (n = 99, 50.8%) was 11 months (95% CI 9.978–12.022). For patients who underwent VATS, the MST of patients who received a lobectomy (n = 50, 52.1%) was 27 months (95% CI 22.432–31.568), the MST of patients who received a sub-lobectomy plus pleurodesis (n = 26, 27.1%) was 27 months (95% CI 19.157–34.843), and the MST of patients who received only pleurodesis (n = 20, 20.8%) was 12 months (95% CI 7.617–16.383).ConclusionFor pulmonary adenocarcinomas with MPE, receiving a lobectomy or sub-lobectomy plus pleurodesis with VATS was associated with improved survival compared with patients who only received thoracic drainage and chemotherapy. Our results and previously published data may justify the use of VATS for treating pulmonary adenocarcinomas with MPE.
The Prognostic Impact of Lymph Node Dissection on Primary Tumor Resection for Stage IV Non–Small Cell Lung Cancer: A Population-Based Study
Authors: Zhang Yudong , Zhang Yichi , Cheng Xinxin , Dai Keyao , Xu Bo , Liang Shujun , Chen Minsheng , Zhang Honglang , Chen Zhenguang 
Published: May 2022

ObjectiveSelected patients with stage IV non–small cell lung cancer (NSCLC) who underwent primary tumor resection have witnessed a survival benefit. Whether additional lymph node dissection (LND) would result in a better effect remain unknown. We investigated the prognostic impact of LND on patients with stage IV NSCLC who received primary tumor resection (PTR).MethodsPatients with stage IV NSCLC who underwent PTR were identified from the Surveillance, Epidemiology, and End Results database from 2004 to 2016. Propensity-score matching was performed to minimize the confounding effect, and lung cancer-specific survival (CSS) and overall survival (OS) were compared after matching. Multivariable Cox regression was used to identify prognostic factors and to adjust for covariates in subgroup analysis. The effect of the number of lymph nodes examined on the CSS was evaluated by repeating the Cox analysis in a binary method.ResultsA total of 4,114 patients with stage IV NSCLC who receive surgery met our criteria, of which 2,622 (63.73%) underwent LND and 628 patients were identified 1:1 in LND and non-LND groups after matching. Compared with the non-LND group, the LND group had a longer CSS (median: 23 vs. 16 months, p &lt; 0.001) and OS (median: 21 vs. 15 months, p &lt; 0.001). Multivariable regression showed that LND was independently associated with favorable CCS [hazard ratio (HR) = 0.78, 95% confidence interval (CI) 0.69–0.89, P &lt; 0.001] and OS (HR = 0.79, 95% CI 0.70–0.89, P &lt; 0.001). Subgroup analysis suggested that LND is an independent favorable predictor to survival in the surgical patients who were older age (&gt;60 years old), female, T3-4, N0, and M1a stage and those who underwent sublobar resection. In addition, a statistically significant CCS benefit was associated with an increasing number of lymph nodes examined through 25 lymph nodes.ConclusionsLND with a certain range of lymph nodes number examined was associated with improved survival for patients with stage IV NSCLC who received primary tumor resection. The results may have implications for guidelines on lymph nodes management in selective advanced NSCLC for surgery.
Immune-Related miRNA-195-5p Inhibits the Progression of Lung Adenocarcinoma by Targeting Polypyrimidine Tract-Binding Protein 1
Authors: Duan Lincan , Wang Juan , Zhang Dahang , Yuan Yixiao , Tang Lin , Zhou Yongchun , Jiang Xiulin 
Published: May 2022

PurposeLung adenocarcinoma (LUAD) is the most common type of cancer and the leading cause of cancer-related death worldwide, resulting in a huge economic and social burden. MiRNA-195-5p plays crucial roles in the initiation and progression of cancer. However, the significance of the miRNA-195-5p/polypyrimidine tract-binding protein 1 (miRNA-195-5p/PTBP1) axis in the progression of lung adenocarcinoma (LUAD) remains unclear.MethodsData were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The starBase database was employed to examine the expression of miRNA-195-5p, while the Kaplan–Meier plotter, UALCAN, and Gene Expression Profiling Interactive Analysis (GEPIA) databases were utilized to analyze the tumor stage and prognostic value of miRNA and PTBP1. Quantitative reverse transcription-polymerase chain reaction assay was conducted to detect the expression levels of miRNA-195-5p in LUAD cell lines and tissues. The effects of miRNA-195-5p on cell proliferation and migration were examined using the cell growth curve, clone information, transwell assays, and wound healing assays.ResultsWe found that miRNA-195-5p was down-regulated in LUAD cancer and cell lines. Importantly, its low levels were related to the tumor stage, lymph node metastasis, and poor prognosis in LUAD. Overexpression of miR-195-5p significantly inhibited cell growth and migration promotes cell apoptosis. Further study revealed that PTBP1 is a target gene of miRNA-195-5p, and overexpression of miRNA-195-5p inhibited the progression of LUAD by inhibiting PTBP1 expression. MiRNA-195-5p expression was related to immune infiltration in lung adenocarcinoma. Moreover, PTBP1 was negatively correlated with diverse immune cell infiltration and drug sensitivity.ConclusionOur findings uncover a pivotal mechanism that miRNA-195-5p by modulate PTBP1 expression to inhibit the progression of LUAD. MiRNA-195-5p could be a novel diagnostic and prognostic molecular marker for LUAD.
Impact of Type 2 Diabetes Mellitus on Endometrial Cancer Survival: A Prospective Database Analysis
Authors: Njoku Kelechi , Agnew Heather J. , Crosbie Emma J. 
Published: May 2022

PurposeType 2 diabetes mellitus (T2DM) is an established risk factor for endometrial cancer but its impact on endometrial cancer survival outcomes is unclear. The aim of this study was to investigate whether pre-existing T2DM impacts survival outcomes in endometrial cancer.Patients and MethodsWomen diagnosed with endometrial cancer were recruited to a single centre prospective cohort study. Relevant sociodemographic and clinico-pathological data were recorded at baseline. T2DM status was based on clinical and biochemical assessment, verified by general practitioner records and analysed in relation to overall, cancer-specific and recurrence-free survival using Kaplan-Meier estimation and multivariable Cox-regression.ResultsIn total, 533 women with median age and BMI of 66 years (Interquartile range (IQR), 56, 73) and 32kg/m2 (IQR 26, 39) respectively, were included in the analysis. The majority had low-grade (67.3%), early-stage (85.1% stage I/II), endometrial cancer of endometrioid histological phenotype (74.7%). A total of 107 (20.1%) had pre-existing T2DM. Women with T2DM had a two-fold increase in overall mortality (adjusted HR 2.07, 95%CI 1.21-3.55, p=0.008), cancer-specific mortality (adjusted HR 2.15, 95% CI 1.05-4.39, p=0.035) and recurrence rates (adjusted HR 2.22, 95% CI 1.08-4.56, p=0.030), compared to those without, in multivariable analyses.ConclusionT2DM confers an increased risk of death in endometrial cancer patients. Well-designed longitudinal studies with large sample sizes are now needed to confirm these findings.
Using Machine Learning for Timely Estimates of Ocean Color Information From Hyperspectral Satellite Measurements in the Presence of Clouds, Aerosols, and Sunglint
Authors: Fasnacht Zachary , Joiner Joanna , Haffner David , Qin Wenhan , Vasilkov Alexander , Castellanos Patricia , Krotkov Nickolay 
Published: May 2022

Retrievals of ocean color from space are important for better understanding of the ocean ecosystem but can be limited under conditions such as clouds, aerosols, and sunglint. Many ocean color algorithms use a few selected spectral bands to perform an atmospheric correction and then derive the upwelling radiance from the ocean. The limitations in the atmospheric correction under certain conditions lead to many gaps in daily spatial coverage of ocean color retrievals. To address these limitations, we introduce a new approach that uses machine learning to estimate ocean color from top of atmosphere radiances or reflectance measurements. In this approach, a principal component analysis is used to decompose the hyperspectral measurements into spectral features that describe the scattering and absorption of the atmosphere and the underlying surface. The coefficients of the principal components are then used to train a neural network to predict ocean color properties derived from the MODIS atmospheric correction algorithm. This machine learning approach is independent of a priori information and does not rely on any radiative transfer modeling. We apply the approach to two hyperspectral UV/VIS instruments, the ozone monitoring instrument (OMI) and the TROPOspheric Monitoring Instrument (TROPOMI), using measurements from 320–500 nm to show that it can be used to reproduce ocean color properties in less-than-ideal conditions. This machine learning approach complements the current atmospheric correction ocean color retrievals by filling in the gaps resulting from cloud, aerosol, and sunglint contamination. This method can be applied to the future hyperspectral Ocean Color Instrument (OCI), which will be onboard NASA’s Plankton, Aerosol Cloud, ocean Ecosystem (PACE) ocean color satellite set to launch in 2024.
Algorithms of Antibiotic Therapy in Outpatient and Inpatient Conditions of Medical Care for Patients with COVID-19 Infection and Bacterial Pneumonia
Authors: Кенденков О.И. , Гавриленко Л.Н. , Кожанова И.Н. , Романова И.С. , Горбич Ю.Л. , Шаранова О.А. 
Published: May 2022

Алгоритмы антибиотикотерапии пациентов с бактериальной пневмонией на фоне инфекции COVID-19 в амбулаторных и стационарных условиях оказания помощи разработаны с учетом индивидуальных особенностей пациентов (степень тяжести заболевания, коморбидность, функция почек), факторов риска осложненного течения и инфицирования внутрибольничной резистентной микрофлорой, спектра противомикробного действия и клинико-фармакологических характеристик антибактериальных препаратов. Предложены разделение антибактериальных препаратов на стандартные и альтернативные препараты и пошаговые подходы к лечению на амбулаторном и стационарных этапах лечения пациентов.
Antibiotic therapy algorithms for patients management with bacterial pneumonia and COVID-19 in outpatient and inpatient care clinics developed on the basis of particular qualities of patients (severity of the disease, comorbidity, kidney function), additional risk factors for complications and infection with nosocomial resistant microflora, the spectrum of antimicrobial activity, and clinical and pharmacological characteristics of antibacterial drugs. A segregation of antibacterial drugs into standard and alternative drugs and step- by-step approaches to the medication of patients at the outpatient and inpatient stages of treatment.
Identifikasi Perilaku Bullying Di Sekolah (Sebuah Upaya Preventif)
Authors: Nur Muhammad , Yasriuddin Yasriuddin , Azijah Nor 
Published: May 2022

<p><em>Penelitian ini membahas tentang perilaku bullying di sekolah. Penelitian ini bertujuan untuk mengetahui bentuk-bentuk perilaku bullying di sekolah dan upaya pencegahan perilaku bullying. Penelitian ini menggunakan metode literature. Hasil penelitian menyebutkan bahwa ada tiga jenis perilaku bullying di sekolah yaitu bullying fisik, bullying verbal dan bullying psikologis. Bullying fisik adalah bullying yang dapat dilihat, contoh bullying fisik yaitu memukul, mencubit, mendorong, menginjak kaki dan melempar dengan barang. Bullying verbal adalah bullying yang dapat didengar, contoh bullying verbal yaitu mengancam, memberikan julukan, mengejek, menyebarkan gosip dan menyoraki. Bullying psikologis adalah bullying yang tidak bisa dilihat dan didengar (berhubungan dengan mental), contoh bullying psikologis yaitu memandang sinis, mendiamkan, memelototi dan mengucilkan. Adapaun upaya pencegahan bullying, yaitu peran serta orang tua, penyuluhan, pembuatan poster anti bullying, pemutaran film anti bullying, peran serta guru bimbingan dan konseling, pengembangan modul bimbingan dan konseling, pengembangan media video bimbingan dan konseling dan peran serta guru mata pelajaran.</em></p>
Enhancing Vocabulary Performance Through Mobile Assisted Language Learning at a Rural School in Indonesia
Authors: Katemba Caroline Victorine 
Published: May 2022

Living in this era of globalization and in the 4.0 industrial revolution, we cannot get away from technology because it has integrated into our lives and has penetrated the educational system. There were studies done on the use of mobile-assisted language learning (MALL) to improve students’ vocabulary achievement in other parts of the world and also in some urban schools in Indonesia, but this study seeks to find whether the students’ vocabulary improved through the use of MALL at rural school in Bandung- Indonesia. This study was carried out to find the enhancement of using MALL in vocabulary teaching to 79 grade 8 students in Bandung. This study was designed for quantitative and experimental research. The students were separated into two groups, experimental and control groups. A day before coming to class, 15-20 words to learn the following day was sent to the experimental group through a short messages system (SMS) for them to read, find the synonyms and meanings of those words before coming to the class. The result of the study showed that students in the experimental group performed better than the control group. It also proves that technology makes a significant difference in the learning of vocabulary in school.