bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencе of peptides from the bursa of Fabricius in broiler chickens on the functional activity of subpopulations of lymphocytes in immunosuppressed mice
Authors: Kolberg N. A. , Tikhonov S. L. , Tikhonova N. V. , Kudryashov L. S. 
Published: July 2022

It is known that peptides inhibit the enzymes of viruses and are able to penetrate into cells by their embedding in the cell membrane, as a result of which the penetration of viruses into the host cell is blocked, which makes it possible to consider peptides as an alterna tive to antiviral drugs. In this regard, the demand for immune-boosting nutraceuticals and functional foods containing biologically active peptides is growing. The immunomodulating effect of the peptides were studied on the mice of the BALb/c line that suffered from experimentally induced immunodeficiency; the mice got injections of peptides isolated from the bursa of Fabricius (bursal sac) of broiler chickens. 5 groups of BALb/c mice were formed. The animals of the 1st group (control one) received physiological saline per os as a placebo, animals of the 2nd group got bursal peptides per os at a dose of 0.02 mg/kg per body weight, the mice of 3rd group (immunosuppressed) got saline per os as a placebo, the 4th group (immunosuppressed) was administered the bursal peptides per os at a dose of 0.02 mg/kg of body weight, the 5th group was held as the control one (immunosuppressed group). Blood for tests was taken on days 1, 7 and 14 of the experiment. The functional activity of neutrophils was determined by the method of spontane ous and induced chemiluminescence. Among the immudepressive animals (the 3rd group) on the 7th day the researchers observed a decrease in CD3+ by 55.3%, CD22+ by 83.7%, CD3+CD4+ by 51.9% and CD3+CD8+ by 54.6% in comparison with the intact (the 1st group). Administration of peptides to immunosuppressed mice (the 4th group) increases the number of subpopulations of CD3+ lymphocytes by 126.6%, CD22+ by 381.6%, CD3+CD4+ by 8.9% and CD3+CD8+ by 81.8% compared to immunosuppressed ani mals, receiving saline per os as a placebo (group 3). Similar results were obtained on the 14th day of the experiment. On the basis of the performed studies, it can be argued that the immunocompetent organs of broiler chickens (bursa of Fabricius) are a promising source of immunotropic peptides.).
Climate change impact on water balance and hydrological extremes in the Lower Mekong Basin: a case study of Prek Thnot River Basin, Cambodia
Authors: Ich Ilan , Sok Ty , Kaing Vinhteang , Try Sophal , Chan Ratboren , Oeurng Chantha 
Published: July 2022

Abstract
Climate change alters hydrological cycles and streamflow regimes at the local, regional and global levels. In this study, we aimed to assess the change in water balance change and hydrological extremes in the Prek Thnot River Basin of the Lower Mekong in Cambodia through a hydrological model (SWAT) under the two climate change scenarios (RCP2.6 and RCP8.5) following three different GCMs. An ensemble of 3 GCMs included GFDL-CM3, GISS-E2-R-CC and IPSL-CM5A-MR models and was applied to a well-calibrated SWAT model through climate change factors. Annual precipitation under RCP2.6 likely decreases by 0.1–0.5% for the near future (2021–2040) and mid-future (2051–2070) and decreases by 0.2–1.3% under RCP8.5. The decrease in precipitation will lead to reductions in water yield by 1–4% (RCP2.6) and 2–5% (RCP8.5). However, peak flow is expected to increase, while the low flow was projected to decrease (1–2% for RCP2.6 and 8–9% for RCP8.5). The study further found that high flow events will increase in both magnitude and frequency. The finding highlights water resources management issues in the Prek Thnot River Basin, including the frequency of future flood events.
Criança com diagnóstico de câncer sob cuidados paliativos e seu familiar: contribuições para o cuidado de enfermagem
Authors: Dias Lilian Laine da Conceição , Santos Larissa Christiny Amorim dos , Ribeiro Wanderson Alves , Fassarella Bruna Porath Azevedo , Alves Ana Lúcia Naves , Neves Keilado Carmo 
Published: July 2022

O presente estudo consiste em uma revisão integrativa da literatura que viabiliza a compreensão do objetivo de levantar a produção científica sobre as ações de enfermagem nos cuidados paliativos junto a criança cm câncer e seu familiar e discutir os principais resultados e suas contribuições para o cuidado de enfermagem. O levantamento bibliográfico foi feito nas bases da Biblioteca Virtual de Saúde (BVS), sendo utilizado as bases de dados Literatura Latino Americana e do Caribe em Ciências da saúde (LILACS), Scientific eletronic Library Online (Scielo) e a Base de Dados da Enfermagem (Bdenf). Através da revisão foi identificado algumas atuações de enfermagem, como ter um cuidado holístico, saber ouvir, ter um contato direto, tocá-la, proporcionar carinho, respeitar os sentimentos e saber proporcionar um ambiente onde esta criança se sinta acolhida, se sinta à vontade e tenha momentos de prazer, já que ela se encontra distante do seu cotidiano, longe do seu lar, da sua família, dos seus amigos, da sua escola, restrita ao lazer. Conclui-se que ter sensibilidade ao cuidar ainda é um grande desafio, pois existe uma grande esfera de pacientes onde a enfermagem tem dificuldade de proporcionar um suporte emocional mais completo e adequando. Ou no caso de uma criança com câncer esse emocional, pode estar mais exacerbado, o que pode alterar a rotina e os sentimentos desse profissional. Tais reflexões podem ser temas de futuros trabalhos e trazer novos subsídios para a assistência a esses pacientes.
Descritores: Enfermagem Pediátrica; Câncer Infantil, Cuidado de Enfermagem; Cuidado Paliativo.
DAMPAK EKOWISATA TERHADAP KESEJAHTERAAN MASYARAKAT DI KAWASAN WISATA AIR TERJUN KOTA BATU
Authors: Permono Eki , Boedirochminarni Arfida , Wahyudi M.Sri 
Published: July 2022

This study had a objective, that is : to analyze about fover the fuction of forest and the walfare in tourist area of Batu waterfall so it can be known are over the forest fuction commensurate with the well being og obtained by local communities. Analysis tools used are descriptive quantitative using t-test, the results of this study showed people's income are changed, this can be seen from the average revenue of the society. Where the average income is Rp 770.000 growing up 77.99% to Rp 1,355,000. The social impact is assessed of changes in the quality and means of education. Improvement of facilities and quality of this became the catalyst so that the public send his son. Healthy life patterns society became better as well as the existence of a new business field that makes labor can be absorbed around the tourist areas. The negative impact of any missed over the function of the forest, that is because of the numbers of visitors to much adn resulted in noise at citizens when entering the rest time.Keywords : environmental impact, Batu waterfall, revenue, social impact, tourist development
ANALISIS SEKTOR EKONOMI UNGGULAN DAN PERGESERAN STRUKTUR PEREKONOMIAN KOTA BATU TAHUN 2012-2016
Authors: Silvya Nadya Bella , Hidayat Wahyu , Syaifullah Yunan 
Published: July 2022

Economic development must include economic growth, where economic development greatly encourages economic growth and economic growth facilitates the process of economic development. With this to know the leading economic sectors in the economy in Batu City in 2012-2016. By using analysis tools Merging Static Location Quotient (SLQ) and Dynamic Location Quotient (DLQ), Klassen Typologies and Shift-Share.The research results obtained that in Batu City based on the analysis of the Merger of Static Location Quotient (SLQ) and Dynamic Location Quotient (DLQ) belonging to the superior economic sector is the economic sector of Construction. The Klassen Typology analysis, which is classified as a fast-developing and fast-growing sector, is the Construction, Large and Retail Trade sector; Reparas for Cars and Motorbikes, Provision of Accommodation and Food Drinking, Information and Communication, and Other Services. While, the Shift-Share analysis which is classified as capable of competing or competitive is the sector of Large Trade and Retail; Repair of Cars and Motorbikes, Provision of Accommodation and Food Drinking, and Construction.
DETERMINAN PENGGELAPAN PAJAK (TAX EVASION) DENGAN RELIGIUSITAS SEBAGAI VARIABEL PEMODERASI
Authors: Jamalallail Ulfa Fauzi , Indarti Maria Goreti Kentris 
Published: July 2022

Tujuan pene1itian ini ada1ah untuk menguji pengaruh machiave11ian, 1ove of money, sanksi perpajakan dan se1f assessment system terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion) dengan re1igiusitas sebagai variabe1 moderasi. Popu1asi yang digunakan da1am pene1itian ini ada1ah wajib pajak orang pribadi yang terdaftar di KPP Pratama Semarang Barat tahun 2020 sebanyak 38.891 wajib pajak orang pribadi. Jum1ah sampe1 da1am pene1itian ini ada1ah sebanyak 100 wajib pajak orang pribadi. Metode pene1itian menggunakan regresi 1inier berganda. Hasi1 ana1isis menunjukkan bahwa machiave11ian berpengaruh positif terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Love of money berpengaruh positif terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Sanksi perpajakan tidak berpengaruh terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Se1f assessment system tidak berpengaruh terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh machiave11ian terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh 1ove of money terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh sanksi perpajakan terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh se1f assessment system terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion).
In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum
Authors: Prawesty Diah Utami  , Febrianti Zuhro Putri Febrianti 
Published: July 2022

Abstract
Indonesia is experiencing a decreased cure rate of malaria caused by the species Plasmodium falciparum. Alternative medicine, in this case, uses marine biota, namely lollyfish (Holothuria atra), which has a lot of active compound content; the purpose uses the biota because many reports that there is a failure of malaria treatment therapy due to Artemisinin-based Combination Therapy (ACT) resistance. The purpose of this study was to find out the antimalarial activity of Holothuria atra extract with ethyl acetate solvent at dose 0.01; 0.1; 1; 10; and 100 Ug/ml against Plasmodium falciparum in vitro. Extract lollyfish using the maceration method. The lollyfish powder will be dissolved with ethyl acetate solvent for 24 hours. Antimalarial activity testing is measured through 4 parameters, namely the measurement of parasitemia rates, % parasite growth, % inhibitory rate, and IC50. Antimalarial activity with ethyl acetate solvent belongs to a very active category with an IC50 value of 1.52 µg/mL. These results can kill the P. falciparum parasite with a percentage that reaches 0%. A decrease in the percentage of growth occurs when the dose given is too low so that the parasite can grow and survive. The result of higher concentrations of extracts will have a higher percentage of resistance to the growth of parasites. The potential for antimalarial activity in lollyfish extract is influenced by the presence of active content such as alkaloids, flavonoids, catechins, and pyrogallol owned by marine biota animals. This study suggests that lollyfish (H. atra) can be developed as an alternative treatment for malaria.
Keywords: Holothuria atra, antimalarial, Plasmodium falciparum, in vitro
PENGARUH CITRA MEREK, KEPERCAYAAN DAN KUALITAS PRODUK TERHADAP LOYALITAS KONSUMEN MIE SEDAAP INSTAN (Studi kasus di daerah Jakarta Barat)
Authors: Sari Fifi Amelia , Muchtar Tafiprios 
Published: July 2022

The research aims to know how brand image, trust and product quality toward loyalty of consumer. Design research using quantitative assosiatif. The sample uses a judmental sampling as much as 145 mie sedaap instan consumer respondents in West Jakarta. Data analysis using structural equation modelling with Partial Least Square (PLS) version 3.2.8. the results showed that the brand image is positive and significant effect toward consumer loyalty mie sedaap instan, trust has a positive and significant toward consumer loyalty mie sedaap instan and quality product effect positively and significantly to consumer loyalty mie sedaap instan.
PENGARUH FINANCIAL LITERACY DAN FINANCIAL ATTITUDE TERHADAP PERILAKU PEMBAYARAN KARTU KREDIT DI UNIVERSITAS MERCU BUANA MERUYA (Studi Pada Mahasiswa Kelas Karyawan Fakultas Ekonomi dan Bisnis Studi Manajemen)
Authors: Amalia Izqi , Haningsih Luna 
Published: July 2022

The use of credit cards in recent years has continued to increase, this is because the cash payment system is considered to reduce the convenience of transactions and is considered to have a relatively high security risk. While the use of credit cards provides a payment system that is more practical, fast, secure and convenient but in its use it requires financial literacy and a good financial attitude so that credit cards can be based on important needs and in accordance with the financial situation of each customer. This study aims to examine the influence of financial literacy and financial attitudes on credit card payment behavior at Mercu Buana Meruya University. The sample used amounted to 73 respondents in students of the Faculty of Economics and Business Management Studies at Mercu Buana Meruya University. The data was collected using questionnaires, the sampling technique used in this study is a non probability sampling technique. The analysis method used in this study is multiple linear regression analysis using SPSS 22. The results showed that financial literacy and financial attitudes had a positive and significant effect on credit card payment behavior.
Twenty-Year Temporal Trends in Risk of Ischemic Stroke in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study
Authors: Gyldenkerne Christine , Kahlert Johnny , Olesen Kevin K. W. , Thrane Pernille G. , Sørensen Henrik T. , Thomsen Reimar W. , Maeng Michael 
Published: July 2022

<p> </p>
<p>Objective<br>
We examined temporal trends in risk of first-time ischemic stroke in patients with incident type 2 diabetes (T2DM) and no prior atherosclerotic cardiovascular disease (ASCVD). </p>
<p>Research Design and Methods<br>
Using nationwide health registries, we identified all patients with incident T2DM without a prior hospital diagnosis of ASCVD from 1996-2015 in Denmark. Patients were assigned to 5-year periods based on the date of T2DM diagnosis and were followed for 5 years. Each patient was matched by sex and age with up to 3 individuals from the general population. Temporal trends in ischemic stroke were examined using Cox regression to compute hazard ratios (HRs). Temporal use of prophylactic cardiovascular medications was also assessed. </p>
<p>Results <br>
The study comprised 288,825 patients with incident T2DM and 782,232 general population individuals. From 1996-2000 to 2011-2015, the 5-year risk of first-time ischemic stroke was approximately halved in the T2DM cohort (5.2% vs. 2.7%, sex- and age-adjusted HR 0.52 [95% CI 0.49-0.55]). Patients diagnosed in 2011-2015 had increased risk of ischemic stroke compared to general population individuals, however, the risk difference narrowed over time (5.2% vs. 2.9% in 1996-1999 [difference 2.3%]; 2.7% vs. 2.0% in 2011-2015 [difference 0.7%]). Use of prophylactic cardiovascular medications increased markedly during the overall study period, especially use of statins (5% to 50%) and multiple antihypertensive drugs (18% to 33%).</p>
<p>Conclusions<br>
From 1996 to 2015, the 5-year risk of first-time ischemic stroke was approximately halved in patients with incident T2DM and no prior ASCVD, coinciding with markedly increased use of prophylactic cardiovascular medications. </p>
Radial Basis Function Neural Network in Vibration Control of Civil Engineering Structure
Authors: Lu Jing , Chen Qinyuan , Mohamed Hamdy 
Published: July 2022

Abstract
This article uses the radial basis function artificial neural network and the MATLAB toolbox to study the vibration control of civil engineering structures. The article proposes a dynamic structure design method based on a generalized radial basis function neural network. Furthermore, the RBF neural network theory is used to optimize the structure-related controller parameters in geotechnical engineering. The research results show that RBF neural network can more accurately predict the vibration response of civil engineering. It can effectively solve the time lag problem in vibration control.
PENGEMBANGAN PRODUK TERI OLAHAN DI PELABUHAN PERIKANAN PANTAI CAROCOK TARUSAN, PROVINSI SUMATERA BARAT
Authors: Astarini Julia Eka , Darmawan  , Putri Rahmavinda Aulia , Arhatin Risti Endriani 
Published: July 2022

Masyarakat yang tinggal di kawasan Pelabuhan Perikanan Pantai Carocok Tarusan mengolah ikan teri menjadi teri asin yang disebut ikan bada cuci. Ikan bada cuci yang dijual di Padang, Bukittinggi, dan Pekanbaru saat ini harganya kalah bersaing dengan produk serupa dari daerah lain. Apabila hal ini berlanjut maka masyarakat akan menderita kerugian dan bahkan kehilangan mata pencaharian. Penelitian ini bertujuan: 1) mengidentifikasi akar penyebab permasalahan harga ikan bada cuci dari Pelabuhan Perikanan Pantai Carocok Tarusan kalah bersaing dengan produk serupa dari daerah lain, 2) memberikan rekomendasi agar harga ikan bada cuci dari Pelabuhan Perikanan Pantai Carocok Tarusan dapat lebih bersaing. Metode penelitian menggunakan metode survei dan teknik pengumpulan data berupa sensus. Tujuan pertama penelitian dicapai dengan menggunakan Diagram Ishikawa. Adapun tujuan kedua dicapai dengan mengidentifikasi proses produksi ikan bada cuci dan peluang penurunan biaya produksinya secara deskriptif. Hasil penelitian menunjukkan bahwa akar penyebab permasalahan harga ikan bada cuci dari Pelabuhan Perikanan Pantai Carocok Tarusan kalah bersaing dengan produk serupa dari daerah lain adalah kurangnya pengetahuan manajemen usaha dan modal usaha dari pengolah. Rekomendasi yang dapat diberikan agar harga ikan bada cuci dari Pelabuhan Perikanan Pantai Carocok Tarusan dapat bersaing antara lain adalah: 1) dari segi biaya produksi, terdapat biaya yang berpeluang untuk dikurangi yaitu harga bahan baku dan harga bahan bantu pengolahan, 2) dari segi teknis, diperlukan modernisasi peralatan pengolah dan pengering, serta 3) dari segi manajemen, diperlukan pelatihan manajemen usaha dan pengembangan pemasaran untuk pengolah.
Kata kunci: Carocok Tarusan, ikan bada cuci, ikan teri, persaingan harga, proses produksi
ANALISIS KEBIJAKAN KESELAMATAN KERJA PADA KEGIATAN OBSERVASI IKAN DAN ALAT PENANGKAPAN IKAN
Authors: Gemilang Achmad Tan'im Makky , Purwangka Fis , Mawardi Wazir , Solihin Akhmad 
Published: July 2022

Aktivitas penyelaman mengandung risiko bahaya Kesehatan dan Keselamatan Kerja (K3) jika pelaksanaannya menyimpang dari prosedur. Oleh karena itu diperlukan usaha preventif yakni antara lain melalui pembuatan peraturan perundang-undangan dan pengawasannya. Tujuan penulisan ini untuk mengkaji kebijakan lembaga-lembaga internasional dan sejauh mana kebijakan nasional mengatur keselamatan pada aktivitas observasi ikan dan alat tangkap. Data yang diambil adalah data pustaka atau telaah dokumen berupa kebijakan/pedoman (guidance) mengenai keselamatan kerja penyelaman dari lembaga internasional dan nasional. Penelitian awal dilaksanakan pada 2018 kemudian disempurnakan pada tahun 2021. Pengumpulan dilakukan dengan cara observasi content analysis yakni merupakan metode pengumpulan data penelitian melalui teknik observasi dan analisis terhadap isi pesan suatu dokumen. Keselamatan pada aktivitas penyelaman ilmiah pada hakekatnya untuk melindungi lingkungan dan orang-orang yang ada di tempat kerja agar terhindar dari kecelakaan. Indonesia baru memulai menerapkan beberapa aturan dan pedoman dari rekomendasi internasional sehingga dalam penerapannya masih terdapat kekosongan peraturan dan ditemukan beberapa kekurangan isi substansi dalam implementasinya. Maka Indonesia perlu melakukan pembenahan dalam kebijakan nasional mengenai keselamatan pada aktivitas selam untuk kepentingan ilmiah.
Kata kunci: ikan, kebijakan, keselamatan kerja, penyelaman
Implementasi PAUD HI (Holistik Integratif) di TK Se-Lombok Timur Tahun 2022
Authors: Mardiana Lis , Suarta I Nyoman , Rachmayani Ika 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui bagaimana implementasi PAUD Holistik Integratif, yang terdiri dari layanan pembelajaran (pendidikan), layanan kesehatan, gizi dan perawatan, layanan peran orang tua dan pengasuhan, layanan perlindungan anak, dan juga layanan keamanan dan kenyamanan di TK Se-Lombok Timur Tahun 2022. Penelitian ini menggunakan metode kuantitatif deskriptif dengan pendekatan survei. Sampel yang digunakan dalam penelitian ini adalah lembaga PAUD yang ada di Kabupaten Lombok Timur, terdiri dari 26 lembaga PAUD. Penarikan sampel dalam penelitian ini menggunakan teknik proportionate stratified random sampling. Alat pengumpulan data menggunakan angket campuran. Teknik analisis data menggunakan formula persentase. Hasil penelitian menunjukkan hal berikut ini, diantaranya implementasi layanan pembelajaran ditemukan kurang holistik integratif dengan perbandingan 57% (15) lembaga melaksanakan dengan kurang holistik integratif dengan 42% (11) lembaga lainnya melaksanakan dengan cukup holistik integratif. Kemudian implementasi layanan kesehatan, gizi dan perawatan, ditemukan implementasinya cukup holistik integratif dengan persentase tertinggi, yaitu 46% (12) lembaga dan kurang holistik integratif. 34% (9) lembaga lainnya sudah holistik integratif dan 19% (5) lembaga lainnya kurang holistik integratif. Layanan peran orang tua dan pengasuhan, implementasinya kurang holistik integratif dengan persentase tertinggi, yaitu 86% (22) lembaga. Layanan perlindungan anak, implementasinya belum holistik integratif dengan persentase tertinggi, yaitu 76% (20) lembaga. Layanan keamanan dan kenyamanan, implementasinya kurang holistik integratif dengan persentase tertinggi, yaitu 73% (19) lembaga dari 26 lembaga yang diteliti. Sehubungan dengan hasil tersebut, lembaga PAUD yang ada di Lombok Timur perlu diadakannya kerjasama layanan perlindungan anak dengan instansi bidang pelindungan anak
Penerapan Permainan Kartu Huruf untuk Mengembangkan Bahasa Keaksaraan Anak Kelompok B di TK Negeri Pembina Labuapi Lombok Barat
Authors: Fahmi Nur , Habibi M.A Muazar , Fahruddin Fahruddin , Astawa I Made Suwasa 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui penerapan permainan kartu huruf untuk mengembangkan bahasa keaksaraan anak kelompok B di TK Negeri pembina labuapi Lombok Barat. Jenis penelitian yang digunakan dalam penelitian ini adalah jenis penelitian kualitatif. Teknik pengumpulan data berupa wawancara, observasi, dan dokumentasi. Faktor yang diteliti dalam penelitian ini yakni guru dan siswa dengan jumlah siswa 14 orang dan 1 orang guru. Pelaksanaan penerapan permainan kartu huruf yang semakin baik membuat perkembangan bahasa keaksaraan anak di setiap tahapnya meningkat dan menjadi lebih optimal. Pada hasil wawancara dan observasi menunjukan bahwa guru telah menerapkan permainan kartu huruf sesuai dengan langkah-langkahnya yaitu dengan menetukan tema, menyiapkan media kartu huruf, mengenalkan huruf dan kata kepada anak, menyiapkan alat dan bahan, membagi anak kedalam beberapa kelompok, dan memberikan kegiatan kepada anak. Hal ini dikarenakan usaha guru yang sangat maksimal dalam menerapkan permainan kartu huruf dalam proses pembelajaran sehingga perkembangan bahasa keaksaraam anak semakin meningkat.