bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solitary extramedullary plasmacytoma in the lung misdiagnosed as lung cancer: A case report and literature review
Authors: Wang Jingjing , Yang Xiaoyun , Liu Xiaomei , He Tao , Liu Bin , Yang Lei , Yuan Fei , Li Jing 
Published: August 2022

BackgroundExtramedullary plasmacytoma (EMP) is an extremely rare kind of soft tissue plasma cell neoplasm without bone marrow involvement or other systemic characteristics of multiple myeloma. Primary pulmonary plasmacytoma (PPP), with no specific clinical manifestations, is an exceedingly rare type of EMP. Because of its complexity, PPP is often difficult to diagnose. Computed tomography-guided percutaneous core needle biopsy (CT-guided PCNB) has been shown to have high sensitivity, specificity and accuracy for characterization of pulmonary lesion, particularly if malignancy is suspected. Here we presented a rare case of PPP diagnosed with CT-guided PCNB.Case presentationA 78-year-old female smoker who visited our outpatient clinic for a mass in the left lower lobe of the lung. Pathological based on CT-guided PCNB yielded a PPP with no lymph node or other distant metastasis.ConclusionsExtramedullary plasmacytoma should be considered in the differential diagnosis of a pulmonary mass.
A preoperative model based on gadobenate-enhanced MRI for predicting microvascular invasion in hepatocellular carcinomas (≤ 5 cm)
Authors: Zhang Sisi , Huo Lei , Zhang Juan , Feng Yayuan , Liu Yiping , Wu Yuxian , Jia Ningyang , Liu Wanmin 
Published: August 2022

PurposeThe present study aimed to develop and validate a preoperative model based on gadobenate-enhanced magnetic resonance imaging (MRI) for predicting microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC) size of ≤5 cm. In order to provide preoperative guidance for clinicians to optimize treatment options.Methods164 patients with pathologically confirmed HCC and preoperative gadobenate-enhanced MRI from July 2016 to December 2020 were retrospectively included. Univariate and multivariate logistic regression (forward LR) analyses were used to determine the predictors of MVI and the model was established. Four-fold cross validation was used to verify the model, which was visualized by nomograms. The predictive performance of the model was evaluated based on discrimination, calibration, and clinical utility.ResultsElevated alpha-fetoprotein (HR 1.849, 95% CI: 1.193, 2.867, P=0.006), atypical enhancement pattern (HR 3.441, 95% CI: 1.523, 7.772, P=0.003), peritumoral hypointensity on HBP (HR 7.822, 95% CI: 3.317, 18.445, P&lt;0.001), and HBP hypointensity (HR 3.258, 95% CI: 1.381, 7.687, P=0.007) were independent risk factors to MVI and constituted the HBP model. The mean area under the curve (AUC), sensitivity, specificity, and accuracy values for the HBP model were as follows: 0.830 (95% CI: 0.784, 0.876), 0.71, 0.78, 0.81 in training set; 0.826 (95% CI:0.765, 0.887), 0.8, 0.7, 0.79 in test set. The decision curve analysis (DCA) curve showed that the HBP model achieved great clinical benefits.ConclusionIn conclusion, the HBP imaging features of Gd-BOPTA-enhanced MRI play an important role in predicting MVI for HCC. A preoperative model, mainly based on HBP imaging features of gadobenate-enhanced MRI, was able to excellently predict the MVI for HCC size of ≤5cm. The model may help clinicians preoperatively assess the risk of MVI in HCC patients so as to guide clinicians to optimize treatment options.
Effect of zinc versus vitamin A supplementation on pediatric patients with community-acquired pneumonia
Authors: Saied Aya , El Borolossy Radwa Maher , Ramzy Mourad Alfy , Sabri Nagwa A. 
Published: August 2022

Background: Community-acquired pneumonia (CAP) is one of the most common infectious diseases affecting the respiratory tract and is responsible for a high mortality rate in children less than 5 years of age. The mortality rate due to CAP is much higher in low/middle-income countries than in high-income countries due to malnutrition and different micronutrient deficiencies that weaken the immune system.Aim: The aim of this study was to compare the effects of zinc and vitamin A, as two elements of micronutrient agents, on the recovery rate of children suffering from CAP aged from 6 months to 5 years. The length of hospital stays was also investigated.Method: A comparative, randomized, open-label, controlled, interventional study was carried out among children less than 5 years of age in the pediatric intensive care unit (PICU) diagnosed with CAP who were randomly divided into three groups. In addition to the standard therapy, group 1 was given zinc, group 2 was given vitamin A, and group 3 was the control group, given the standard therapy only. We compared the three groups in terms of recovery rate and hospital stay.Result: The duration of hospitalization following zinc and vitamin A supplementation was reduced by an average of 3.21 days (95% CI: 5.01–1.41, p = 0.01) and 2.43 days (95% CI: 4.29–0.57, p = 0.01), respectively, compared to the control group. In addition, the two groups of vitamin A and zinc supplementation were associated with a shorter duration of pneumonic effusion (p &lt; 0.001) in comparison to the control group. Additionally, there was no significant difference between the effects of zinc and vitamin A when compared to each other in terms of duration of hospital stay and pneumatic effusion.Conclusion: The administration of zinc or vitamin A supplementation proved to be useful as an add-on therapy in community-acquired pneumonia, where it reduced the length of hospital stay and the duration of pneumonic effusion in pneumonic children less than 5 years of age.
The role of in vitro testing in pharmacovigilance for ß-lactam-induced serum sickness-like reaction: A pilot study
Authors: Elzagallaai Abdelbaset A. , Abuzgaia Awatif M. , Del Pozzo-Magaña Blanca R. , Loubani Eman , Rieder Michael J. 
Published: August 2022

Background: Current pharmacovigilance (PV) methods for detection of adverse drug reactions (ADRs) fail to capture rare immune-mediated drug hypersensitivity reactions (DHRs) due to their scarcity and the lack of clear diagnostic criteria. Drug-induced serum sickness-like reactions (SSLRs) are rare type of DHRs that occur in susceptible patients 1–3 weeks after exposure to the culprit drug with ß-lactam antibiotics being the most associated drugs. The diagnosis of drug induced SSLR is difficult due to the lack of safe and reliable diagnostic tests for identifying the culprit drug. The lymphocyte toxicity assay (LTA) is an in vitro test used as a diagnostic tool for drug hypersensitivity reactions (DHRs).Objective: To evaluate the role of the LTA test for diagnosing and capturing SSLR due to ß-lactam antibiotics in a cohort of patients.Methods: Patients were recruited from patients referred to the Drug Hypersensitivity Clinic at Clinic at London Health Science Centre with suspicion of drug allergy. Twenty patients (10 males and 10 females) were selected to be tested to confirm diagnosis. Demographic data was collected form the patents and blood samples were withdrawn from all patients and from 20 healthy controls. The LTA test was performed on all subjects and data is expressed as percentage increase in cell death compared to control (vehicle without the drug).Results: In the result of LTA tests performed on samples from the selected 20 patients. There was a significant (p &lt; 0.05) concentration-dependent increase in cell death in cells isolated from patients as compared to cells from healthy controls when incubated with the drug in the presence of phenobarbitone-induced rat liver microsomes.Conclusion: Giving its safety and good predictive value the LTA test has very strong potential to be a useful diagnostic tool for ß-lactam-induced SSLR. The test procedure is relatively simple and not overly costly. Further studies including other drug classes are needed to evaluate the utility of the LTA test for SSLR due to other drugs.
Automatic quantifying and monitoring follow-ups for implantable collamer lens implantation using AS-OCT images
Authors: Sun Yiming , Li Jinhao , Xu Peifang , Chen Pengjie , Wang Yaqi , Hu Shaodan , Jia Gangyong , Wang Shuai , Ye Juan 
Published: August 2022

Purpose: To develop a deep learning method to automatically monitor the implantable collamer lens (ICL) position and quantify subtle alterations in the anterior chamber using anterior segment optical coherence tomography (AS-OCT) images for high myopia patients with ICL implantation.Methods: In this study, 798 AS-OCT images of 203 patients undergoing ICL implantation at our eye center from April 2017 to June 2021 were involved. A deep learning system was developed to first isolate the corneoscleral, ICL, and lens, and then quantify clinical important parameters in AS-OCT images (central corneal thickness, anterior chamber depth, and lens vault).Results: The deep learning system was able to accurately isolate the corneoscleral, ICL, and lens with the Dice coefficient ranging from 0.911 to 0.960, and all the F1 scores >0.900. The relative error between automated measurements and the ground truth for 95% (188 images out of 198) of LVs was within 10%. Intraclass correlation coefficients (ICCs) of the machine-ground truth measurements ranged from 0.928 to 0.995. The deep learning method also showed better repeatability than human graders.Conclusion: The deep learning method provides reliable detection and quantification of AS-OCT scans for postoperative ICL implantation, which can simplify and optimize the management of clinical outcomes of ICL implantations. Also, this is a step towards an objective measurement of the postoperative vault, making the data more comparable and repeatable to each other.
Kirkpatrick-Baez mirrors commissioning for coherent scattering and imaging endstation at SXFEL
Authors: Tong Yajun , Fan Jiadong , Nie Yonggan , Guo Zhi , Gao Zichen , Yuan Xinye , He Bo , Chen Jiahua , Zhang Difei , Luan Hui , Zhang Jianhua , Lu Donghao , Xie Minghan , Cheng Peng , Feng Chao , Liu Tao , Deng Haixiao , Liu Bo , Liu Zhi , Jiang Huaidong 
Published: August 2022

Shanghai Soft X-ray Free-Electron Laser (SXFEL) is the first X-ray free-electron laser facility in China. The initial commissioning of the beamline was carried out in May 2021. Herein, we present a status report and the first experimental results obtained during the early commissioning of Kirkpatrick-Baez (KB) mirrors for the Coherent Scattering and Imaging (CSI) endstation, including three types of diagnostics. A bright X-ray focal spot of less than 3 μm was achieved by using edge-scan and silicon ablation imprint measurements. In order to confirm the spot size, the attenuated beam and full beam are used respectively for the two measurement methods.
Molecular characterization of adenosine monophosphate deaminase 1 and its regulatory mechanism for inosine monophosphate formation in triploid crucian carp
Authors: Zhou Yonghua , Zuo Anli , Li Yingjie , Zhang Yu , Yi Zilin , Zhao Dafang , Tang Jianzhou , Qu Fufa , Cao Shenping , Mao Zhuangwen , Jin Junyan , Liu Zhen 
Published: August 2022

Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 (AMPD1) gene is a key gene in IMP formation. At present, the research on the mechanism of AMPD1 regulating IMP formation in aquatic animal is still blank. In this study, in order to study the mechanism of AMPD1 regulating IMP formation in fish, the full open reading frame (ORF) of AMPD1 which was 2160bp was obtained for the first time in triploid crucian carp (Carassius auratus). It encoded 719 amino acids with a molecular mass of 82.97 kDa, and the theoretical isoelectric point value was 6.31. The homology analysis showed that the homology of triploid crucian carp and diploid Carassius auratus was the highest, up to 99%. And the phylogenetic tree showed that triploid crucian carp was grouped with diploid Carassius auratus, Culter alburnus, and Danio rerio. And real-time fluorescence quantitative results showed that AMPD1 was expressed specifically in muscle of triploid crucian carp (p &lt; 0.05). The results of detection the localization of AMPD1 in cells indicated that the AMPD1 was mainly localized in cytoplasm and cell membrane. Further, we examined the effects of glutamate which was the promotor of IMP formation on the expression of AMPD1 and the formation of IMP in vivo and in vitro experiments, the results showed that 3% glutamate and 2 mg/ml glutamate could significantly promote AMPD1 expression and IMP formation in triploid crucian carp muscle tissue and muscle cells (p &lt; 0.05). Then we inhibited the expression of AMPD1 in vivo and in vitro experiments, we found the formation of IMP in muscle tissue and muscle cells of triploid crucian carp all were inhibited and they affected the gene expression of AMPK-mTOR signaling pathway. The all results showed that AMPD1 mediated glutamate through AMPK-mTOR signaling pathway to regulate the formation of fish IMP.
Increased anxiety from fear of Omicron in China as compared to North America and Western Europe: A cross-sectional Kendall’s tau-b analysis using the generalized anxiety disorder 7-item questionnaire
Authors: Shan Dan , Liu Chang , Li Shaoyang , Zheng Yuandian 
Published: August 2022

BackgroundPolicies dealing with the Coronavirus Disease 2019 (COVID-19) pandemic vary across the globe, the different governmental responses then affect the public perception of COVID-19. Many unofficial Chinese media outlets frequently spread misinformation about COVID-19 and exaggerated reports of rare sequelae of Omicron for monetization and attention seeking, leading to panics in the Chinese public. In comparison the attitudes toward Omicron in other countries around the world, especially in North America and Western Europe have shifted to a more relaxed stance.ObjectiveThis article primarily aims to investigate the association between Chinese people’s attitudes toward the potential after-effects of Omicron and their anxiety status, as compared to these of people living in North America or Western Europe.MethodsWe conducted a questionnaire survey via the Credamo and collected valid data from 500 Chinese (not living in Shanghai), another 500 Chinese (living in Shanghai) and 500 people living in North America or Western Europe in June 2022. Kendall’s coefficient of rank correlation tau-sub-b was used to examine this association.ResultsThe results suggested that subjective attitudes of Chinese participants toward the sequelae of Omicron were positively and significantly associated with their anxiety status [i.e., the Generalized Anxiety Disorder 7-item (GAD-7) scores] in Shanghai (China) (Tb = 0.44, p &lt; 0.01) and other parts of China outside Shanghai (Tb = 0.37, p &lt; 0.01). However, no such significant correlation was found in North America &amp; Western Europe (Tb = -0.01, p &gt; 0.05).ConclusionOur findings showed that Chinese participants who were more worried about the after-effects of Omicron had higher levels of anxiety. Although it is true that Long COVID-19 should be a concern, exaggerated media reporting can impact negatively on an individual’s mental wellbeing. Only through the dissemination of robust scientific studies, the misinformation and the fears that follow it can be put to rest.
Global burden and trends of firearm violence in 204 countries/territories from 1990 to 2019
Authors: Ou Zejin , Ren Yixian , Duan Danping , Tang Shihao , Zhu Shaofang , Feng Kexin , Zhang Jinwei , Liang Jiabin , Su Yiwei , Zhang Yuxia , Cui Jiaxin , Chen Yuquan , Zhou Xueqiong , Mao Chen , Wang Zhi 
Published: August 2022

BackgroundGaps remained in the updated information of the firearm violence (FV) burden from a global landscape. Understanding the global burden of FV could contribute to decision-making.MethodsData on the FV burden, including physical violence by firearm (PVF), self-harm by firearm (SHF), and unintentional firearm injuries (UFI), were extracted from the Global Burden of Disease 2019. The temporal trends of age-standardized rate (ASR) were estimated using estimated annual percentage change (EAPC).ResultsIn 2019, PVF, SHF, and UFI reported 710.64 × 103, 335.25 × 103, and 2,133.88 × 103, respectively, incident cases worldwide. Their ASR (/100,000 people-years) were 9.31, 4.05, and 28.07. During 1990–2019, the overall incident ASRs of PVF presented an increasing trend (EAPC = 0.61, 95% confidence interval [CI]: 0.48 to 0.75). Notably, pronounced increasing trends were observed in Tropical Latin America, and North Africa and Middle East. However, incident trends of SHF and UFI declined globally, with the respective EAPCs being −0.68 (95% CI: −0.83 to −0.54) and −0.98 (95% CI: −1.19 to −0.77). In 2019, the ASR of death due to PVF, SHF, and UFI were 2.23, 0.65, and 0.26, and that of DALYs were 127.56, 28.10, and 17.64, respectively. Decreasing trends in the ASRs of FV were observed in most regions and countries worldwide over the past three decades, particularly that of PVF in Estonia.ConclusionThe FV burden was heterogeneous across regions and countries, which was deeply subjected to socioeconomic factors. The findings highlighted that specific prevention strategies and interventions were required, particularly in the high prevalent settings.
Workplace violence against doctors in China: A case analysis of the Civil Aviation General Hospital incident
Authors: Xiao Yu , Du Na , Chen Jia , Li Ya-lan , Qiu Qin-ming , Zhu Shao-yi 
Published: August 2022

BackgroundViolence against health professionals is a global public health problem. In 2019, a doctor was killed in Civil Aviation General Hospital (CAGH), which triggered national discussion about hospital violence. Sina Weibo, the Chinese version of Twitter, played an important role in this public discussion. The CAGH incident provides us with an opportunity to explore how social media was used in the discussion on violence against doctors.MethodsUsing the built-in search engine of Sina Weibo, a data set containing 542 Chinese micro-blogs was established. Three keywords: Civil Aviation General Hospital, doctor, and knife were used to search for related posts between December 24th, 2019 and January 19th, 2020. We made a content analysis of the posts to investigate: Weibo users' demographics, views about the incident of CAGH, and measures to prevent hospital violence.ResultsOverall, 89.3% of the posts were sent by individual Weibo users, and 10.7% by organizations. Among the individual users, doctors accounted for 27.4%, but only 1.0% came from the legal profession. In addition, 86.7% of the micro-blogs expressed sympathy for the attacked doctor, and 23.1% of the micro-blogs thought that the imperfect medical system was the main cause of the accident. Nearly half of the posts described their disappointment with the government and the society, and 58.6% of medical staff users expressed regret for engaging in medical work. Only 14.2% of micro-blogs put forward some constructive strategies to prevent hospital violence.ConclusionWeibo users played an important role in spreading and discussing the CAGH incident. However, constructive measures to protect doctors were rarely mentioned, and legal opinions were not reflected in time. Hospital violence has caused public dissatisfaction with the government and weakened the professional confidence of medical staff. Occupational health and public health stakeholders must take effective measures to solve workplace violence against doctors.
Automated quantification of penile curvature using artificial intelligence
Authors: Abbas Tariq O. , AbdelMoniem Mohamed , Chowdhury Muhammad E. H. 
Published: August 2022

ObjectiveTo develop and validate an artificial intelligence (AI)-based algorithm for capturing automated measurements of Penile curvature (PC) based on 2-dimensional images.Materials and methodsNine 3D-printed penile models with differing curvature angles (ranging from 18 to 88°) were used to compile a 900-image dataset featuring multiple camera positions, inclination angles, and background/lighting conditions. The proposed framework of PC angle estimation consisted of three stages: automatic penile area localization, shaft segmentation, and curvature angle estimation. The penile model images were captured using a smartphone camera and used to train and test a Yolov5 model that automatically cropped the penile area from each image. Next, an Unet-based segmentation model was trained, validated, and tested to segment the penile shaft, before a custom Hough-Transform-based angle estimation technique was used to evaluate degree of PC.ResultsThe proposed framework displayed robust performance in cropping the penile area [mean average precision (mAP) 99.4%] and segmenting the shaft [Dice Similarity Coefficient (DSC) 98.4%]. Curvature angle estimation technique generally demonstrated excellent performance, with a mean absolute error (MAE) of just 8.5 when compared with ground truth curvature angles.ConclusionsConsidering current intra- and inter-surgeon variability of PC assessments, the framework reported here could significantly improve precision of PC measurements by surgeons and hypospadiology researchers.
Sustaining a nursing best practice guideline in an acute care setting over 10 years: A mixed methods case study
Authors: Nadalin Penno Letitia , Graham Ian D. , Backman Chantal , Fuentes-Plough Jessica , Davies Barbara , Squires Janet 
Published: August 2022

BackgroundTo improve patient outcomes many healthcare organizations have undertaken a number of steps to enhance the quality of care, including the use of evidence-based practices (EBPs) such as clinical practice guidelines. However, there is little empirical understanding of the longer-term use of guideline-based practices and how to ensure their ongoing use. The aim of this study was to identify the determinants and knowledge translation interventions (KTIs) influencing ongoing use of selected recommendations of an institutional pain policy and protocol over time from an organizational perspective and 10 years post implementation on two units within an acute care setting.MethodsWe conducted a mixed methods case study guided by the Dynamic Sustainability Framework of an EBP 10 years post implementation. We examined protocol sustainability at the nursing department and unit levels of a multi-site tertiary center in Canada. Data sources included document review (n = 29), chart audits (n = 200), and semi-structured interviews with nurses at the department (n = 3) and unit (n = 16) level.ResultsWe identified 32 sustainability determinants and 29 KTIs influencing ongoing use of an EBP in acute care. Three determinants and eight KTIs had a continuous influence in all three time periods: implementation phase (0–2 yrs), sustained phase (&gt;2–10 yrs.), and at the 10-year mark. Implementation of KTIs evolved with the level of application (e.g., department vs. unit) to fit the EBP within the context highlighting the need to focus on determinants influencing ongoing use. Sustainability was associated with continual efforts of monitoring and providing timely feedback regarding adherence to recommendations. KTIs used to embed recommendations into routine practices/processes positively influenced high adherence rates. Use of a participatory approach for implementation and sustainment and linking KTIs designed to incrementally address low adherence rates facilitated sustainment.ConclusionThis research provides insight into the relationship between implementation and sustainability determinants and related KTIs during implementation and sustained use phases. Unique determinants identified by department and unit nurses reflect their different perspectives toward the innovation based on their respective roles and responsibilities. KTIs fostered changed behaviors and facilitated EBP sustainment in acute care. Findings confirm the concept of sustainability is a dynamic “ongoing process.”