bluuebunny/crossref_metadata_2025_split huggingface dataset:
lnc-THRIL and miR-125b relate to disease risk, severity, and imbalance of Th1 cells/Th2 cells in allergic rhinitis
Authors: Song Ji , Liu Dan , Yin Weizhi 
Published: May 2022

Objective: Tumor necrosis factor and HNRNPL-related immunoregulatory long noncoding RNA (lnc-THRIL) and its target microRNA (miR)-125b are reported to regulate immune response through several means by participating in allergic rhinitis (AR) pathology. This study aimed to investigate the role of lnc-THRIL and miR-125b in detecting AR risk, and to further explore their correlation with disease severity and cytokines released from T helper type (Th) 1 and Th2 in AR patients.
Methods: A total of 160 AR patients and 80 subjects with severe snoring symptoms (as controls) were recruited. Nasal mucosa samples were collected to measure the expressions of lnc-THRIL, miR-125b, and Th1 and Th2 cytokines by reverse transcription quantitative polymerase chain reaction.
Results: The expression of lnc-THRIL decreased while that of miR-125b increased in AR patients when compared with that of controls, and further receiver operating characteristic curve showed that both could well distinguish AR patients from controls. Furthermore, lnc-THRIL negatively correlated with miR-125b in AR patients. lnc-THRIL was negatively correlated with Individual Nasal Symptom Score (INSS) (including nasal rhinorrhea score, sneezing score, and congestion score) and Total Nasal Symptom Score (TNSS), and miR-125b was positively associated with INSS (including itching score, sneezing score, and congestion score) and TNSS. Moreover, lnc-THRIL was correlated with increased Th1 cytokines (interferon-gamma (IFN-γ) and interleukin (IL)-2) but with decreased Th2 cytokines (IL-4 and IL-10), while miR-125b exhibited opposite trends in AR patients.
Conclusion: lnc-THRIL and its target (miR-125b) relate to disease risk, symptom severity, and Th1/Th2 imbalance of AR, suggesting their potential as biomarkers for AR management.
Momordica charantia polysaccharides alleviate diarrhea-predominant irritable bowel syndrome by regulating intestinal inflammation and barrier via NF-κB pathway
Authors: Ji Shanyun , Zhang Qing 
Published: May 2022

Background: Momordica charantia exerts anti-inflammatory effect against ulcerative colitis. Momordica charantia polysaccharides (MCPs) attenuate gastritis through inhibition of ethanol-induced inflammatory response.
Objective: The role of MCPs in diarrhea-predominant irritable bowel syndrome (IBS-D) is investigated.
Materials and Methods: Chemical stimulation followed by acute and chronic pressure stimulation was used to establish rats model with IBS-D. The model rats were then administrated with MCPs. Defecation frequency, fecal water content and abdominal withdrawal reflex (AWR) score were then recorded. Pathologic changes in the colonic tissues were evaluated by hematoxylin and eosin staining. Inflammation was detected by ELISA and qRT-PCR, and immunohistochemistry was used to assess intestinal mucosal permeability.
Results: First, IBS-D of mice wasIBS-D ratsmice exhibited many abnormal clinical manifestations, including increased frequency of defecation, fecal water content, and abdominal withdrawal reflex (AWR) score. Second, the mice were administrated with MCPs, which reduced frequency of defecation, fecal water content, and AWR score, and 100-mg/kg MCPs indicated therapeutic effect on IBS-D mice equivalent to rifaximin. Moreover, MCPs also ameliorated pathologic changes in the colonic tissues of IBS-D mice. Third, inflammatory response in IBS-D mice was also suppressed by MCPs through up-regulation of Interleukin (IL)-10, and down-regulation of tumor necrosis factor-α (TNF-α), Interleukin(IL)-1β, and IL-6. MCPs enhanced levels of occludin (OCLN) and zona occludens protein-1 (ZO-1) in IBS-D mice to improve intestinal mucosal permeability. Finally, phosphorylation of p65 in IBS-D mice was reduced by MCP treatment.
Conclusion: MCPs ameliorated intestinal permeability and repressed intestinal inflammation to attenuate IBS-D by inactivating nuclear factor kappa B (NF-κB) signaling.
Pulse Period Identification Method for Pulse-Like Ground Motions Oriented to Structural Maximum Inelastic Response
Authors: Li Cuihua , Zeng Hongyi , Zuo Zhanxuan , Zhang Yutao , Bao Xu 
Published: May 2022

ABSTRACTPulse period is an important indicator of pulse-like effects on structural response. An alternative algorithm to identify the pulse period is proposed oriented to the structural maximum inelastic response using an equivalent trigonometric function for the dominant velocity half-cycle (DVHC). This study highlights the correlation between the DVHC and the maximum inelastic displacements of single-degree-of-freedom system. Compared with two pioneering methods that occasionally overestimate or underestimate the pulse period, it is shown that the proposed algorithm is more appropriate in predicting the pulse period. In addition, robust scaling laws that relate the pulse period to appropriate seismological, spatial, and site parameters are proposed and evaluated.
Clinical cases of Pseudomonas aeruginosa eradication in patients with cystic fibrosis
Authors: Zhekaite E. K. , Kondratyeva E. I. 
Published: May 2022

Pseudomonas aeruginosa is the most common highly pathogenic flora in patients with cystic fibrosis. It is associated with severe lung damage and affects life expectancy. According to the register of patients with cystic fibrosis in the Russian Federation (2019), the incidence of P. aeruginosa pulmonary infection among them is 34.3%. Inhaled tobramycin is the drug of choice for the eradication of P. aeruginosa in patients with cystic fibrosis according to European and Russian recommendations. Clinical studies showed that Bramitob is highly effective against P. aeruginosa infection in patients with cystic fibrosis.The aim of the study: to demonstrate the effectiveness and safety of eradication therapy with inhaled tobramycin in several clinical cases of children with cystic fibrosis.Methods. The article analyzes 6 clinical cases of effective eradication of P. aeruginosa in patients with cystic fibrosis, including 1 clinical case that involved a new approach to assessing the resistance of P. aeruginosa. Positive culture of P. aeruginosa was confirmed in all patients in specialized laboratories (State Budgetary Healthcare Institution “Morozov Children’s City Clinical Hospital of the Department of Health of the City of Moscow”, Federal State Budgetary Institution “N.F.Gamaleya National Research Center for Epidemiology and Microbiology”, Ministry of Health of the Russian Federation). All patients received inhaled tobramycin 300 mg 2 times a day for 1 – 3 courses (a course of 28 days of inhalations/28 days – a break).Results. All children tolerated tobramycin well, and two of them were younger than 6 years old. The effectiveness of eradication was confirmed by negative cultures of P. aeruginosa during 1-year follow-up that included quarterly microbiological control. The clinical case that involved assessment of resistance to inhaled tobramycin is especially important because of polyresistance of the pathogen.Conclusion. The presented clinical cases of eradication of P. aeruginosa with the use of tobramycin confirm its clinical efficacy and wider application possibilities.
Edukasi dan Pendampingan Anak Usia Sekolah Dasar dan Menengah di Tengah Pandemi Covid-19
Authors: Zahara Laxmi , Kertanah Kertanah , Syahidi Khaerus , Novianti Baiq Aryani , Fartina Fartina 
Published: May 2022

Pandemi COVID-19 sangat berdampak pada kehidupan masyarakat dunia khususnya dalam hal kesehatan dan pendidikan. Kurangnya kesadaran tentang pentingnya kesehatan oleh masyarakat di desa serta kurang optimalnya pembelajaran di sekolah membuat anak–anak usia sekolah dasar dan menengah menghabiskan waktu liburnya dengan banyak bermain tanpa menjaga jarak di masa pandemi. Kegiatan PKM ini bertujuan untuk mengurangi kebebasan berinteraksi dan mengoptimalkan pembelajaran anak usia sekolah dasar dan menengah di tengah masa pandemi dengan mengedukasi serta pendampingan pada masyarakat dusun Ketapang desa Menceh. Peserta pada kegiatan ini adalah peserta didik dari tingkat TK (30 orang), SD (50 orang) dan SMP (75 orang). Edukasi kesehatan dilakukan melalui program Posyandu, cuci tangan dan penyuluhan protokol kesehatan sedangkan pendampingan proses belajar–mengajar dilakukan dengan memberikan bimbingan belajar, mengajar TPQ dan pelatihan seperti pembuatan bros dan menggambar. Edukasi tentang kesehatan memberikan pengetahuan arti pentingnya menjaga jarak, kebersihan khususnya di saat pandemi. Bagaimanapun, kegiatan pendampingan pembelajaran dapat memberikan motivasi pentingnya pendidikan saat ini dan masa yang akan datang. Dengan memberikan edukasi tentang kesehatan dan pendampingan dalam pembelajaran kepada masyarakat bisa memahami tentang menjaga kebersihan, menjaga jarak dan juga dapat dijadikan motivasi untuk terus belajar meskipun terkendala khususnya di era pandemi ini. COVID-19 influences the life of the population worldwide, especially in health and education aspects. Lack of awareness of the meaning of health and the importance of education makes primary and secondary school ages of children spend their time playing without keeping social distancing in this pandemic era. This community service aims to minimize social interaction and optimize their learning during this pandemic by providing education and accompaniment at Ketapang, Menceh village. Education of health was carried out through Posyandu, hand washing and health education programs, while accompaniment program was done by tutoring, teaching TPQ and skill training like drawing, make a brooch. Educating them about health gave them the knowledge of social distancing and hygiene crucial during the pandemic. However, the Accompaniment of education is also essential to motivate motivation that education is essential today, but it is also for the future. By giving education in health and accompaniment in a lesson, they understood that keeping hygiene and social distancing motivated them to continue learning although constrained, especially for this pandemic situation.
Pelatihan Penulisan Buku Antologi Non-Fiksi Pengalaman Belajar Fisika pada Mahasiswa Calon Guru Fisika
Authors: Fitriah Lutfiyanti 
Published: May 2022

Kegiatan ini bertujuan untuk melatih mahasiswa menulis buku antologi non-fiksi tentang pengalaman hidup sehingga dihasilkan sebuah buku antologi yang dapat diterbitkan secara nasional. Metode yang digunakan adalah ceramah, tanya jawab, penugasan, dan corrective feedback (umpan balik korektif) dari dosen selaku mentor kepada mahasiswa. Instrumen penilaian yang digunakan pada kegiatan ini adalah lembar penilaian artikel antologi yang diadaptasi dari Badan Standar Nasional Pendidikan. Peserta kegiatan berjumlah 22 orang mahasiswa calon guru fisika di Program Studi Tadris Fisika FTK UIN Antasari Banjarmasin. Kegiatan workshop terselenggara secara daring dengan baik dan lancar pada tanggal 24 Juni sampai 10 Agustus 2021. Berdasarkan kegiatan yang diselenggarakan diketahui bahwa mahasiswa telah mampu menulis dengan baik. Hasil dari kegiatan ini adalah diterbitkannya sebuah buku antologi non-fiksi dengan judul “Aku dan Fisika: Penggalan Pengalaman Seru Saat Belajar Fisika” secara nasional. Selain itu, mahasiswa menjadi termotivasi untuk menghasilkan buku lainnya. This activity aimed to train students to write non-fiction anthology books about life experiences to produce an anthology book that can be published nationally. The methods used were lecture, question, assignment, and corrective feedback from the lecturer as a mentor to students. The assessment instrument used in this activity was an anthology article assessment sheet adapted from the Badan Standar Nasional Pendidikan. The activity participants were 22 prospective physics teacher students at Physics Education Department, FTK UIN Antasari Banjarmasin, from June 24 to August 10, 2021. Workshop activities were held online well and smoothly. Based on the activities held, it was known that students were able to write well. The result of this activity was the publication of a non-fiction anthology book with the title "Aku dan Fisika: Penggalan Pengalaman Seru Saat Belajar Fisika" nationally. In addition, students become motivated to produce other books.
Pembinaan Nilai-Nilai Keislaman Bagi Masyarakat Muslim Minoritas di Desa Handiwung Kabupaten Katingan
Authors: Hunainah Hunainah , Zannah Fathul , Permadi Ade Shalahudin , Solikhin Asep 
Published: May 2022

Desa Handiwung terletak di daerah pelosok yang baru berkembang dengan pengetahuan masyarakat yang minim tentang pelaksanaan ibadah yang sesuai dengan syariat agama Islam. Sesuai dengan observasi awal, permasalahan umum yang seringkali dihadapi oleh masyarakat muslim di Desa Handiwung diantaranya tidak terlalu lancar membaca Al-Qur’an, oleh karena itu kegiatan pengabdian masyarakat ini dilaksanakan dengan tujuan untuk melakukan pembinaan kepada masyarakat muslim minoritas di Desa Handiwung sehingga dapat lebih memahami tata cara pelaksanaan ibadah menurut syariat agama Islam. Kegiatan pembinaan nilai-nilai Islam bagi masyarakat di Desa Handiwung dilaksanakan selama 4 bulan yaitu dari bulan Agustus hingga November 2021, dengan menggunakan metode ceramah, diskusi dan demonstrasi. Hasil kegiatan yang dilaksanakan yaitu pemahaman peserta kegiatan mengalami peningkatan baik tentang membaca Al-Quran, thaharoh, dan pelaksanaan mengurus jenazah. Handiwung Village is located in a remote area that is just developing with minimal public knowledge about implementing worship following Islamic law. Following initial observations, common problems that are often faced by the Muslim community in Handiwung Village include not being too fluent in reading the Qur'an. Therefore, this community service activity is carried out to guide the minority Muslim community in Handiwung Village to be more understand the procedures for carrying out worship according to Islamic religious law. The activity of fostering Islamic values for the community in Handiwung Village was carried out for four months, from August to November 2021, using lecture, discussion and demonstration methods. The results of the activities carried out were that the participant's understanding of the activities had increased both in reading the Koran, thaharoh, and the implementation of taking care of the corpse.
Pendampingan Penyusunan RPP (Rencana Pelaksanaan Pembelajaran) Kurikulum 2021 Bagi Guru Bahasa Indonesia di MTs Negeri Se-Kabupaten Cirebon
Authors: Nuryanto Tato , Uswati Tati Sri , Mulyaningsih Indrya , Khuzaemah Emah 
Published: May 2022

Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kompetensi guru Bahasa Indonesia di MTs se-Kabupaten Cirebon. Kegiatan ini dilaksanakan pada 20 November 2021 dengan 30 peserta. Metode yang digunakan adalah penyuluhan dan pendampingan. Pada pertemuan awal, para guru diberi penjelasan dan tanya jawab terkait HOTS, TPACK, Pembelajaran Abad 21, dan Pelajar Pancasila. Setelah dirasa cukup, para peserta dibagi menjadi tiga kelompok, yakni kelompok kelas 7, 8, dan 9. Masing-masing kelompok berjumlah 10 guru. Setiap kelompok menyusun RPP sesuai yang diampu. Hasil pendampingan menunjukkan bahwa belum semua peserta mengetahui tentang HOTS, TPACK, Pembelajaran Abad 21, dan Pelajar Pancasila. Peserta tidak yakin sudah menggunaan teknologi informasi secara efektif dalam pembelajaran. Peserta belum maksimal dalam menyusun RPP. Hal ini terkait keterbatasan waktu. Bahkan sebagian besar peserta tidak membawa laptop sebagai sarana untuk menyusun RPP. Kegiatan ini dirasa belum maksimal. Oleh karena itu, para peserta meminta agar kegiatan seperti ini dilaksanakan secara rutin dan berkelanjutan sesuai kesepakatan yang tertuang dalam Nota Kesepahaman antara Jurusan Tadris Bahasa Indonesia FITK IAIN Syekh Nurjati Cirebon dengan MGMP Bahasa Indonesia MTs Kabupaten Cirebon. This community service aims to improve the competence of Indonesian language teachers in MTs throughout the Cirebon Regency. This activity was on 19 November 2021, with 30 participants. The method used is counseling and mentoring. At the initial meeting, the teachers were explained and asked questions related to HOTS, TPACK, 21st Century Learning, and Pancasila Students. After it was deemed sufficient, the participants were divided into the 7th, 8th, and 9th-grade groups. Each group consisted of 10 teachers. Each group prepares lesson plans according to what they are taught. The results of the mentoring show that not all participants know about HOTS, TPACK, 21st Century Learning, and Pancasila Students. Participants were not sure that they had used information technology effectively in learning. Participants have not been maximal in compiling the RPP. This is related to time constraints. Most of the participants did not bring a laptop to prepare lesson plans. This activity is not optimal. Therefore, the participants requested that actions like this be carried out regularly and continuously according to the agreement in the Memorandum of Understanding between Tadris Bahasa Indonesia Department FITK IAIN Syekh Nurjati Cirebon and the Indonesian Language MGMP MTs Cirebon Regency.
Pembekalan Pendidikan Kewirausahaan Berwawasan Gender bagi Mahasiswa Perintis Wirausaha di Banjarmasin Menuju Pemberdayaan Ekonomi Masyarakat
Authors: Nurhikmah Nurhikmah , Rusvitawati Devi , Anisa Nor , Nadila Nadila 
Published: May 2022

Kesenjangan gender masih terjadi di berbagai bidang pembangunan, salah satunya di bidang ekonomi. Pemahaman gender saat ini banyak dipengaruhi oleh budaya lokal dan dibangun dari pemikiran yang tidak tepat dan mengakibatkan munculnya praktik diskriminatif dan kekerasan di masyarakat. Oleh karena itu, harus ada pemahaman yang benar dan tepat tentang kesetaraan dan keadilan gender. Pemahaman tersebut dapat terus dilembagakan di semua lapisan masyarakat, termasuk Perguruan Tinggi dalam melaksanakan Tri Dharma. Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk meningkatkan peran Universitas dalam memfasilitasi bimbingan teknis dengan menggunakan Strategi Pengarusutamaan Gender. Selain itu juga memberikan pembekalan, pelatihan, dan pendampingan bagi Mahasiswa pionir wirausaha yang berperan sebagai agen informasi, edukasi, dan komunikasi melalui Strategi Pengarusutamaan Gender dalam pembangunan nasional, khususnya pemberdayaan ekonomi masyarakat. Pendekatan Participatory Rural Appraisal (PRA) digunakan dalam pengabdian ini. Peserta, 25 Mahasiswa dari enam perguruan tinggi di Banjarmasin, difasilitasi menerapkan PRA untuk merencanakan, melaksanakan, memantau, dan mengevaluasi Kegiatan Kewirausahaan Mahasiswa berbasis gender. Alhasil, penyusunan program Kegiatan Kewirausahaan Mahasiswa yang responsif gender di Banjarmasin berhasil menumbuhkan kesadaran kuat Mahasiswa bahwa PRA adalah alat untuk mewujudkan pemberdayaan ekonomi. The gender gap still exists in the economic field. The current gender understanding is heavily influenced by local culture and built from inappropriate thinking, resulting in discriminatory practices and violence. Therefore, there must be a right and proper understanding of gender equality and equality. The understanding can continue to be institutionalized in society through all levels, including Universities’ role in implementing the Tri Dharma. This study aimed to increase the University’s role in facilitating technical guidance for entrepreneurial pioneer students through Gender Mainstreaming Strategy in national development, especially community economic empowerment. A Participatory Rural Appraisal (PRA) was used to facilitate 25 students from six universities in Banjarmasin in planning, implementing, monitoring, and evaluating the Student Entrepreneurship Activities based on gender-oriented entrepreneurship. As a result, the preparation of programs for gender-responsive Student Entrepreneurship Activities in Banjarmasin has succeeded in raising students' strong awareness that PRA is a tool for realizing economic empowerment.
Pencegahan Hipertensi dengan Penerapan Tidur Yang Berkualitas Pada Masyarakat Di RT 08 / Rw 08 Kelurahan Lenteng Agung Jakarta Selatan
Authors: Sihura Sancka Stella Ganiasnda , Gunardi Saiful , Pratiwi Panca , Martin Edo Fidelis , Suratinah Suratinah 
Published: May 2022

Hipertensi merupakan penyebab utama yang mengakibatkan kematian jantung dan disabilitas, dan sekitar 1.3 miliar penduduk di seluruh dunia menderita penyakit tersebut. Hasil observasi di lapangan didapatkan bahwa masyarakat sering mengalami keluhan nyeri kepala, disertai dengan peningkatan tekanan darah yang cukup signifikan terutama pada masyarakat lanjut usia. Edukasi terkait peningkatan kualitas dan durasi tidur menjadi salah satu strategi tepat yang dapat dilakukan mengingat terdapat hubungan yang signifikan antara durasi tidur yang pendek dan hipertensi. Metode dilakukan dengan langkah-langkah melakukan peninjauan ke lingkungan RT 008/ RW 008 pada tanggal 27 Januari 2022, melakukan observasi dan pengukuran tekanan darah serta melakukan pre-test terkait tingkat pengetahuan masyarakat terhadap tidur yang berkualitas, melakukan edukasi terkait strategi tidur yang berkualitas dan merekamnya dalam video agar masyarakat bisa mengulang materi edukasi setiap hari jika diperlukan, melakukan post-test terkait tingkat pengetahuan masyarakat terhadap strategi tidur yang berkualitas, melakukan evaluasi, melakukan analisis data univariat dengan pengumpulan data yang disajikan dalam bentuk tabel distribusi frekuensi. Hasil post-test menunjukkan responden mengalami peningkatan pengetahuan terkait hipertensi dan sleep management sebesar 94,16%. Penyuluhan kepada masyarakat terkait strategi tidur yang berkualitas mempunyai manfaat untuk menurunkan resiko hipertensi. Hypertension is the leading cause of cardiac death and disability, and about 1.3 billion people worldwide suffer from the disease. The observations showed that people often experience headaches, accompanied by a significant increase in blood pressure, especially in the elderly. Education related to improving sleep quality and duration is one of the appropriate strategies that can be carried out, considering a significant relationship between short sleep duration and hypertension. The method is carried out by the steps of conducting a review of the citizen, observing and measuring blood pressure as well as conducting a pre-test related to the level of public knowledge about quality sleep, conducting education related to quality sleep strategies, and recording it in the video so that the public can repeating educational materials every day if needed, conducting post-tests related to the level of public knowledge of quality sleep strategies, conducting evaluations, conducting data analysis. The post-test results showed a significant increase (94.16%) in knowledge related to sleep quality before and after counselling. Counselling the community regarding quality sleep strategies has benefits for reducing the risk of hypertension.