bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Effect of Soft Coagulation for Air Leak Treatment during Pulmonary Lobectomy
Authors: Takahashi Yuki , Maki Ryunosuke , Tsuruta Kodai , Tada Makoto , Arai Wataru , Shindo Yuma , Nakamura Yasuyuki , Miyajima Masahiro , Watanabe Atsushi 
Published: June 2022

Abstract
BackgroundSoft coagulation using the VIO soft coagulation system is used to treat minor lung air leaks during pulmonary resection in Japan. We previously reported that it has a similar effect as the air leak treatment with fibrin glue. We evaluated the efficacy of soft coagulation using the VIO soft coagulation system for lung air leakage during pulmonary resection.MethodsIntraoperative air leaks from the interlobar lung parenchyma were observed in 42 of the 283 patients who underwent video-assisted thoracoscopic surgery lobectomy between 2016 and 2018. We retrospectively reviewed these 42 patients who were treated using the VIO soft coagulation system for air leaks. We classified the air leaks in to grades using the Macchiarini scale score and evaluated the surgical outcomes of air leak treatment.Results Air leaks from the interlobar lung parenchyma having Macchiarini scale scores 1, 2, and 3 occurred in 8, 17, and 17 patients, respectively. In all the 8 patients with score 1 air leaks (100%), the air leaks could be controlled using the VIO soft coagulation system alone, and none had delayed pneumothorax requiring intervention. Of the score 2 and 3 air leaks, 52.9% and 35.3% were controlled using the VIO soft coagulation system alone, respectively.Conclusions Macchiarini scale score 1 air leaks from the interlobar lung parenchyma could be well controlled using the VIO soft coagulation system. Therefore, soft coagulation with this system may be an alternative method for treating minor air leaks during pulmonary resection surgery.
A CNN-based Lower Limb Motion Quality Evaluation Method for Home-based Stroke Rehabilitation
Authors: Ge Pin , Huang Ziyang , Tang Guoliang , Kumar Akshay , Mahmoud Seeahmed , Fang Qiang , Chen Jian 
Published: June 2022

Abstract
Background: With the rapid increase of stroke incidence in recent yearsworldwide, home-based rehabilitation training has become more needed,especially for remote regions or in developing countries where rehabilitationresources are scarce. Studies have demonstrated that home-based rehabilitationfor poststroke patients is essential for reducing the cost as well as for providingefficient rehabilitation. Nevertheless, home-based rehabilitation training requireseffective professional support and timely evaluation. Method: In this paper, a home-based rehabilitation quality evaluation methodfor lower limb training was proposed. The kinematic data of a patient’s lowerlimb during a set of selected training exercises was captured by a wireless bodyarea sensor network (WBASN). The data was then processed by a convolutionalneural network (CNN) based algorithm to classify the rehabilitation training typeand to evaluate the training quality. A series of kinematic features were selectedfor rehabilitation quality scoring. The experiments have been conducted using 26human participants, including 6 healthy participants and 20 stroke patients atdifferent Brunnstrom recovery stages. Results: An accuracy of 95.3% has been achieved for recognizing therehabilitation training types and a statistically significant linear positivecorrelation (R2 = 0.9962) has been obtained between the objective scores andthe Brunnstrom stages evaluated by the clinicians.
Qualitative study of process in daily life of patients with larynx/pharyngeal cancer before total laryngectomy
Authors: Kotake Kumiko , Haba Kaori , Kurita Mami , Ota Ichiro , Suzukamo Yoshimi , Kai Ichiro , Iwanaga Kazuyo , Takahashi Aya , Ishibashi Yoko , Uemura Hirokazu , Hara Yoriko , Atrata Yukiko , Kinoshita Yasuhito 
Published: June 2022

Abstract
Background
Many patients with larynx/pharyngeal cancer only become aware of the disease in an advanced stage due to hoarseness and a strange feeling upon swallowing. The aim of this study was to discuss what kinds of support are required for these patients by clarifying the process in their daily life prior to total laryngectomy.
Methods
A qualitative study was performed using the Modified Grounded Theory Approach in patients with larynx/pharyngeal cancer before total laryngectomy. In a semi-structured interview, patients were asked to talk freely about their health conditions, problems, and anxieties. Information on age, sex, family members living with the patient, occupation, diagnosis, staging, and subjective symptoms was also obtained in the interview.
Results
The analysis theme of “How do cancer patients live before surgery?” had a storyline centered on {surviving surgery}. The patients had a [strange feeling] caused by a sense of a lump in the throat and pain of hoarseness, as well as [unexperienced anxiety] for their first experience of hospitalization and surgery. The core category and the two categories interacted with each other and recurred. [Unexperienced anxiety] was related to [cannot imagine] daily life after hospital discharge, and transitioned to [not knowing what will happen after surgery] until the time comes. The core category of {surviving surgery} and the three categories interacted with each other and recurred. The patients also had a positive mindset of [having a purpose in life after hospital discharge] and were [looking for positives] at that time, while making a [request of support from physicians] to improve their [strange feeling]. Quality of life (QOL) prior to laryngectomy is influenced by negative mental and physical feelings caused by cancer and by anxieties about postoperative life, but with hope for social support.
Conclusions
Patients experience a “transition” before total laryngectomy, and at this turning point they try to think positively about surviving the surgery, but also feel loneliness, fear, and anxiety. These findings suggest the need for a healthcare team approach for pre- and postoperative support by staying close to a patient, even after hospital discharge.
Synthesis of plant-mediated silver nanoparticles using Veronica anagallis-aquatica extract; Optical and biological properties
Authors: Ahmed Mushtaq , Khan Aman , Mushtaq Nadia , Sher Naila , Khan Rahmat Ali 
Published: June 2022

Abstract
There is an increasing commercial demand for nanoparticles due to their wide applicability in various areas such as electronics, catalysis, chemistry, energy, and medicine. Metallic NPs are traditionally synthesized by wet chemical techniques, where the chemicals used are quite often toxic and flammable. The focus of the current study was the green synthesis of silver nanoparticles (AgNPs) from 1 mM silver nitrate (AgNO3) solution using an aqueous solution of Veronica anagallis-aquatica (V. anagallis-aquatica). Fixed ratio of AgNO3 and plant extract was mixed and conformation of AgNPs was done by UV visible spectroscopy; which showed a maximum absorption peak at 425 nm. The Fourier transformed spectroscopy (FTIR) spectrum shows various peaks for different functional groups bearing compounds that had played role in the bioreduction of AgNPs. Scanning electron microscopy (SEM) analysis demonstrated that AgNPs were spherical with a size of about 20 nm calculated by Nano measurer software. The average size of 11.45 nm was calculated using four major peaks 38°, 44°, 64°, and 78° of X-rays diffraction (XRD) analysis. The chemical composition of AgNPs was revealed by Energy dispersive X-ray (EDX). The atomic and weight percentages of Ag, Na, Mg, and O were 73.55, 17.91, 6.78, 1.75, and 60.58, 21.20, 8.49, and 9.74. EDX confirmed the intense sharp peak at 73.55 keV. The in vitro antioxidant, antibacterial, antifungal, antidiabetic, and TBARS were found with positive results. The current study concluded that V. anagallis-aquatica possesses the ability to synthesize AgNPs. These synthesized AgNPs showed enhanced properties compared to the V. anagallis-aquatica.
A 5-year outcome of Propranolol for the treatment of paediatric intracranial cavernoma: Case report and a review of the literature
Authors: Tiefenbach Jakov , Park Jay J , Kaliaperumal Chandrasekaran 
Published: June 2022

Abstract
We describe a case of a young male patient with KRIT1 driven familial cavernous malformation syndrome who developed multiple brain cavernomas, intracranial bleeding, and persistent seizures. Due to the relentless growth of cavernous malformations and recurrent intracranial bleeds, it was decided to enrol the patient in the “Propranolol for Intracranial Cavernoma” (PICC) pilot trial at our institution. Over the five-year treatment period with 20–40mg oral propranolol three times daily (TDS), we noted near-complete arrest of the growth of cavernous malformations with no further evidence of intracranial bleeding or any further seizures. The observed outcome is consistent with the extremely limited published literature on the topic; thus, this case provides important evidence that supports the use of propranolol as a prophylactic treatment for paediatric intracranial cavernomas. We strongly encourage and recommend future prospective randomized controlled trials to definitively assess and characterize the therapeutic utility of propranolol in this patient population.
Trends and outcomes of Alcoholic Intoxication in Trauma Patients
Authors: Yeganeh Zhobin , Cuervo Catherine , Rahimi Murwarid , Kopatsis Anthony P , Kopatsis Anthony 
Published: June 2022

Abstract
Background:We sought to investigate the rate and trends of alcohol intoxication in different ages and sexes during last decade.Methods:Multivariate analysis was used to compare alcohol intoxication in different sexes and age groups and to investigate the trends present during the 2007-2019 period using TQP database.Results:We found 1,000,578 intoxicated trauma patients admitted to level I-III trauma centers during 2007-2019 within TQP database. Overall, 21.7% of intoxicated patients were women. The rate of intoxicated women increased significantly from 20.6% in 2007 to 33% in 2019. Intoxicated women have a significantly higher rate of self-inflicted trauma compared to intoxicated men (10.4% vs. 2.4%, P<0.01). Overall, 29.7% of intoxicated trauma patients had chronic alcohol abuse and the rate increased by age. Chronic alcohol abuse was higher in men (30.1% vs. 28.2%, OR: 1.09, CI:1.08-1.10, P<0.01) and elderly patients (age≥65) (39.8% vs. 28.9%, OR:1.62, CI: 1.60-1.65, P<0.01). Overall mortality for intoxicated trauma patients was 2.8%. Mortality of intoxicated men was higher than women (2.9% vs. 2.2%, OR: 1.32, CI: 1.28-1.37, P<0.01). Elderly intoxicated patients (age≥65) had a significantly higher mortality (4.9% vs. 2.6%, OR: 1.91, CI: 1.84-1.98, P<0.01). Also, elderly men had twice the mortality risk compared to elderly women (5.7% vs. 3%, OR: 1.96, CI: 1.80-2.14).Conclusion:There is a gradual increase in the rate of alcoholic intoxication in women with trauma during 2007-2019. Intoxicated women have a significantly higher rate of self-inflicted trauma compared to intoxicated men. Elderly patients with alcoholic intoxication, especially men, have a higher mortality. Further studies are needed to investigate preventive strategies for the increasing rate of alcoholic intoxication in women.
Analysis of albedo as well as disc effects at the Jacobi constant and their stability of equilibrium points in the generalized restricted four-body problem
Authors: Kumar Manoj , Kushvah Badam Singh 
Published: June 2022

Abstract
The valuable facets of the dynamics are its stability and the components that disturb stability behavior. Our purpose in this research work is to examine the fundamental analysis of equilibrium points and their linear stability under the solar radiation pressure, albedo force effects, and radiatingoblateness in the generalized restricted four-body problem. The significant elements of this problem are mass parameter µ and other disturbing parameters to the unique influential potential function and its required derivatives to the primaries. An important relation in albedo parameters and their possible range is derived. The analysis of the albedo and disc effect is observed on the Jacobi’s constant and the positions of the existing equilibrium points and their stability regions are discussed. The inhibited zone of motion by the infinitesimal body is shown for different planetary systems. The particular as well as the joint effect of solar radiation pressure at first, albedo at second, and radiating-oblateness at both primaries of the mass, a disc is observed. The scatter diagram of locations of the mass as well as equilibrium points plotted for planetary systems. The behavior of monotonicity of the existing equilibrium points is analyzed for the presence as well as the absence of perturbations of taken planetary systems. Due to such prevalence, the considered perturbing forces give a significant perturbation in the RFBP. This current study can be extended later to the design of orbits for the different planetary systems.
Expressive Speech Synthesis by Modeling Prosody with Variational Autoencoders for Bangla Text-to-Speech
Authors: Ahmad Arif , Selim Mohammad Reza , Iqbal Muhammed Zafar , Rahman Mohammad Shahidur 
Published: June 2022

Abstract
With the advent of deep learning, Text-to-Speech (TTS) research has made a great leap in producing natural speech. The state-of-the-art TTS systems generate average prosody, resulting in a lack of variety and expressiveness found in human speech. To avoid synthesizing monotonous speech and averaged prosody, it is desirable to have a way of modeling the variation in the speech prosody. To generate highly expressive speech, we explore two approaches of synthesizing speech in this work. The first one is a feed-forward transformer model conditioned on the fundamental frequency. The other model uses a variational autoencoder augmented with normalizing flows and an adversarial training process. We have trained three internal Bangla (also known as Bengali) datasets containing varying amounts of expressive speeches. We provide a comparative study regarding the effect of the proportion of expressive voices in the training data. Both the subjective and objective evaluations confirm that the proposed models outperform the autoregressive Tacotron2 baseline.
ADAM10 gene polymorphism and its relationship to hepatocellular carcinoma in Egyptian HCV patients receiving direct-acting antiviral therapies (DAAs)
Authors: fert Ashraf El , EL-Sabaawy Dalia , Ghanem Samar , elgedawy gamalat , Yehia sania , bedair hanan , razek Wael Abdel , awad samah , emam mostafa 
Published: June 2022

Abstract
Background: Hepatocellular carcinoma (HCC) is a multifactorial disease needs widened genetic studies. Taking in consideration the probable role of new direct-acting antiviral therapies (DAAs) of Hepatitis C infection (HCV) as predisposing factor of HCC as it provides longer lifetime for many late cirrhotic patients to develop hepatocellular carcinoma. Considering the reported potential biological roles of ADAM 10 in inflammation and carcinogenesis. These intrigued the idea of the study to investigate the ADAM 10 rs.653765 SNP genetic polymorphism in the HCC occurrence (de novo and post DAAs).Methods: This prospective study was conducted on 360 participants divided to 4 groups. Group 1: 90 chronic adult patients infected with HCV received couple of DAAs regimens and evolved HCC during the period of follow up(36 months) . Group 2: Another 90 HCV patients received the same DAAs regimens and did not show HCC spread or manifestations during the same follow up period. Group 3 included 90 de novo HCC patients (did not receive any DAAs). Finally, a 90 apparently healthy participants as group4. ADAM 10 genotyping. clinical and laboratory data were evaluated in Laboratories of Clinical Biochemistry and Molecular Diagnostics Department National Liver Institute, Menoufia University.Results: the study showed a statistically significant difference between HCC denovo and HCC deterioration on top of DAAs treatment study group regarding child Pugh scoring system, BCLC and HKLC staging scorings, p- value(<0.05) and that (90%) of HCC denovo group were in child score( A 5,6) and (40%) of them were in HKLC (IIIa )stage in addition (56.7%) were in (B) BCLC stage. Also, a statistically highly significant difference between HCC on top of treatment group and HCV study group regarding DAAs drug regimen received (p value=0.000) was found where (85.6%) of HCC on top of treatment received (SOF/DAC/RBV) drug regimen for treatment of HCV and regarding SVR in the 2 groups where (33.3%) of HCC on top of treatment group undergone relapse (p value=0.000).The study showed a statistically highly significant difference between CC versus CT+TT genotypes of HCC study groups regarding their child ,BLC and HKLC staging system. No difference in survival distribution between HCC de novo and on top of DAAs.Conclusion: No differences in the registered death rate recorded between the followed studied groups denovoHCC and HCC post DAAs treatment with more aggressiveness and advanced staging of HCC post DAAs. Also, showed increased risk of HCC incidence among HCV patients receiving(SOF/DAC/RBV) drug regimen and appreciates ADAM 10 genotyping
Changes in social mixing and attitudes and practices to precautionary measures in a maturing COVID-19 epidemic in six communities in Sudan: A Qualitative Study
Authors: Ahmed Salma A.E. , Koura Rahaf Abu , Ahmed Abd Elhameed , Abdalla Omama , Hassan Omnia Kamal , Tom Ahmed , Eldirdiri Ahmed , Ismaeil Drieg , Zainalabdeen Israa , Nurelhuda Nazik , Ahmed Aljaile , Abdan Afrah , Dahab Maysoon , Abdelmagid Nada 
Published: June 2022

Abstract
IntroductionWith low COVID-19 vaccination coverage, non-pharmaceutical interventions remain critical to mitigating the COVID-19 epidemic in Sudan. We explore changes in social contact patterns, risk perception, attitudes, and practices towards protective measures during an evolving COVID-19 outbreak in six illustrative communities in Sudan.Methods This qualitative study took place in six communities in five Sudanese states using focus group discussions with community members and non-participant structured observations in public spaces. A total of 117 participants joined 24 group discussions. We used a two-stage thematic analysis. ResultsThe perceived importance of precautionary measures was higher than reported and observed adherence. Adherence was consistently low throughout the epidemic and was mainly driven by enforced movement restrictions. As restrictions were lifted, social contacts outside the household resumed pre-COVID-19 levels, and risk perception and individual and institutional adherence to protective measures diminished. We identified an environment that is socially and economically unsupportive of preventive practices, compounded by widespread rumours, misinformation and mistrust in the government-led response. However, we identified new social habits that can contribute to reducing COVID-19 transmission.ConclusionThe unfavourable social and economic environment, coupled with the low visibility of the epidemic and epidemic response, has likely modulated the influence of higher risk perception on adopting precautionary behaviours by individuals. Governments and non-governmental actors should increase the visibility of the epidemic and epidemic response, enforce and incentivise infection control measures in public areas, promote emerging preventive social habits, and actively track and address rumours and misinformation related to COVID-19 and COVID-19 vaccines.
Assessing garden pea germplasm for powdery mildew resistance through disease phenotyping and genotyping using molecular markers
Authors: Sharada Priyambada , MAKANDAR RAGIBA 
Published: June 2022

Abstract

Erysiphe pisi is the causal agent of powdery mildew disease in garden pea. So far, the resistance genes comprising two recessive (er1 and er2) and one dominant (Er3) have been reported to confer resistance to powdery mildew in garden pea. A set of 46 pea genotypes were screened against the E. pisi isolate, Ep01 in greenhouse conditions to identify resistant genotypes. Disease phenotyping and genotyping were carried to test for resistance/susceptibility through gene-specific sequence characterized amplified region (SCAR) markers. The presence of the resistant genes in the control pea genotypes; JI2302 for er1 gene, JI2480 for er2 gene and P660-4 for Er3 were confirmed through their respective gene-specific markers. The pea genotype, Arkel served as a negative control. Screening of the pea germplasm revealed three genotypes as highly resistant, six genotypes as resistant while ten genotypes were moderately resistant, thirteen genotypes were moderately susceptible, nine genotypes were susceptible and five were highly susceptible. The molecular markers for er1 resistance gene Sc-OPE-161600 was found to be segregating in most of the pea genotypes except in the susceptible control, Arkel. The marker ScX17_1400 for er2 gene was found to be in homozygous condition in the resistant pea genotypes while the marker associated with Er3 resistance, SCW4637 was found to be in heterozygous condition in majority of the pea lines except in the resistant control genotype, P660-4.
Quality Identification of Kale Cultivated under Different Light Treatments by Hyperspectral Imaging Technology
Authors: Yao Zhijie , Jiang Haozhao , Wu Huilin , Tang Xinyu , Xu Haitao , Liu Houcheng , Deng Haidong , Lan Yubin , Zhang Xinlong , Liu Yutao , Zhao Jing , Long Yongbing 
Published: June 2022

Abstract
The development of a new method to accurately and non-destructively identify the quality of vegetables cultivated under different light treatments is urgent because traditional methods of quality identification are time-consuming, costly and destructively. A method based on hyperspectral imaging technology combined with machine learning was developed in this paper to rapidly identify the quality of kale cultivated under different light treatments in a plant factory. UV-A supplementation in different photoperiods was used to regulate the quality of kale by improving the contents of moisture, photosynthetic pigments and the phytochemicals accumulation, and the quality grades were first established based on these indicators obtained by the traditional method. Then, a non-destructive quality identification method was presented by constructing an identification model based on the hyperspectral images of kale leaves and machine learning. It was revealed that the accuracy of the identification model based on linear discriminant analysis reached a high value of 95% by employing different feature selection methods to optimize the model. The differences of model accuracy were also investigated when the reflectance spectra extracted from different regions of interest (ROIs) such as whole leaf, mesophyll and leaf veins were used for modeling. It was shown that the quality identification models had higher accuracy when the mesophyll was used as ROI than others ROIs, indicating that the selection of ROI-mesophyll was an efficient way to improve the accuracy of the model. These results demonstrate that the proposed method combining hyperspectral imaging technology and machine learning can be used to rapidly and accurately identify the quality of vegetables cultivated under different light treatments.