bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assembling Academic Persona and Personhood in a Digital World
Authors: Ortiz-Vilarelle Lisa 
Published: December 2022

Digital automedia have become a standard mechanism for academics seeking to construct and promote their professional profiles. Through a range of autobiographical forms enabled by the digital age, on-line platforms, including blogs, Facebook groups, and Twitter, have become something of a business card for academics. But what about the self-authored personnel narratives that are not shared publicly and serve, nonetheless, as self-portraits of academic life?. Even tenure and promotion applications, employment letters, and CVs, the most often required documents to gain and maintain access to professional opportunity in academia, are going digital. And they are evolving with the digital age. In some stages of personnel review, those requests are made and via digital methods. Software used for standardization and efficiency, mediates representation of academic subjectivity by restricting users to entering details according the parameters set not only by the standards of the profession, the institutional subscriber, but also by the operating system. Increasing reliance on such systems further reduces academic personhood to chartfields and biodigital data entry that is counter-intuitive to the syncretic processes of making meaning by which individuals experience, remember, and recount their lives inclusive of their careers. My essay turns to narrative theory to assess the impact of digital tools and methods of personnel review on the assemblage and portraiture of academic subjectivity.
Perovskite CsPbBr3 single-crystal detector operating at 1010 photons/s/mm2 for ultra-high flux X-ray detection
Authors: Pan Lei , Pandey Indra , Miceli Antonino , Klepov Vladislav , Chung Duck Young , Kanatzidis Mercouri 
Published: December 2022

Abstract
Semiconductors for detecting hard radiation are confronted with considerable problems when operating at high photon fluxes. We report a perovskite CsPbBr3 single-crystal detector capable of operating at X-ray fluxes of up to 1010 photons/s/mm2 with beam area ≤ 0.25 mm2 at 58.61 keV for current-mode X-ray detection. The spectrometer-grade CsPbBr3 detectors show a gamma-ray energy resolution of ~7.5% at 122 keV for 57Co and dark current as low as 4.3 nA (0.5 nA/mm2) at a reverse bias voltage of 200 V (118 V/mm). The detector was tested at X-ray energies of 8.2, 10, and 58.61 keV at a synchrotron light source under a reverse bias voltage of up to 1000 V (588 V/mm). Under a sufficiently high bias voltage and within several hundreds of seconds X-ray exposure, good photocurrent linearity (goodness of fit R2 > 0.99) and reproducibility were obtained up to a flux of ~ 1010 photons/s/mm2 at beam area 0.25 mm2 with Lower Limit of Detection of ~105 photons/s/mm2 and Charge Collection Efficiency of ~100% for 58.61 keV X-rays. Accordingly, wide application of CsPbBr3 detectors in high-flux X-ray detection is anticipated.
Designing an Analysis Framework for estimating life of a component subjected to a constant load and a single overload using MATLAB
Authors: Rauf Malik Nauman , Khan Rahma , Majeed Gohar 
Published: December 2022

Abstract
Actual Structures are subjected to variable amplitude loading as opposed to a monotone. Many models have been proposed to study these effects analytically. The proposed study focuses on developing an algorithm, and a corresponding framework in MATLAB for two of these models, i.e. the NASGRO equation for constant amplitude loading, and Generalized-Willenborg for overload effects. The overload influence is modeled by keeping track of changes in the crack-tip plastic-zone. Two cases are studied with the algorithm, and the results indicate that the presence of overload tends to retard crack growth, thereby validating our algorithm with literature findings.
Evidence of local adaptation in temperature tolerance traits of the gametophytic and sporophytic stages in Solanum carolinense (horsenettle)
Authors: Chandler Emma K. , Travers Steven E. 
Published: December 2022

Abstract
Climate change is rapidly altering local temperature regimes and in different ways across the landscape. To cope with these rapid changes, plant species must have the capacity to respond to changes in temperature stress or risk extinction. We compared temperature tolerance traits in Solanum carolinense populations from Texas and Minnesota to understand how a species adapts to extreme temperature stress. We examined traits in both the gametophytic and sporophytic stages to differentiate between these distinct phases of selection and determine whether there is a correlation between the two. We found that temperature sensitivity differed between populations of the south that face extreme heat regularly and northern populations that do not. The results were not completely consistent with our expectations, including counter-gradient results in both the sporophyte and gametophyte. There were also no correlations in temperature tolerance between the two life-stages, suggesting that there are different temperature tolerance strategies in the gametophyte and sporophyte. Our results support the adaptation of a potential avoidance mechanism to mitigate extreme heat in the gametophyte. These findings indicate that wild populations have the potential to adapt to rising temperatures due to climate change in the future.
Application of wetland waste plant biochar in combination with arbuscular mycorrhizal fungi on immobilization of Cd in contaminated soil
Authors: Qiu Liang , Zhu Qi lin , Luo Qing hua , Li Hai lan , Yan Jia li , Liao Tao , Li Xin 
Published: December 2022

AbstractIn this study, biochar pyrolyzed from different wetland waste plants (Reed,Typha,Canna) was used to immobilize Cd in contaminated soil. The results showed that biochar could all enhance the residual Cd2+in soil. Moreover, Ca500 (pyrolyzed at 500 ℃ fromCanna) showed the best immobilization capacity due to its larger surface, higher number of pores and its regular, smooth structure. Optimum conditions for Ca-500 immobilization to Cd2+in soil were: amount 6% (wt%) and contacting time 16 weeks, the exchangeable and the state of bound to carbonates of heavy metals reduced 92.08% and 67.64%, respectively. After combining biochar with arbuscular mycorrhizal, the results showed that the combined system could more effectively reduce the transportable Cd content in soil, increase the proportion of residual Cd, effectively reduce the migration of Cd, improve the biomass and root length of vegetables, reduce Cd absorption by vegetables and the ability of vegetables to transfer Cd from root to the upper part, and reduce the edible safety risk. Simultaneously, biochar with arbuscular mycorrhizal can improve the antioxidant capacity of vegetables and their resistance to heavy metals, optimize the composition of soil microbial community, and improve soil microbial abundance and community β-diversity. It can also significantly change the functional gene expression of soil microorganisms, soil fertility, and the self-healing ability to heavy metals.
Routine (7 days) vs. clinically indicated change of the noninvasive ventilator circuit for prevention of hospital-acquired pneumonia: Protocol for a randomized controlled trial in 2 tertiary hospitals
Authors: Zhang Xiaolong , Zhu Jing , Wang Lili , Wu Ying , Lin Ji , Wang Minjin , Wang Feng , Zeng Yihua , Wang Wenxiu , Han Yao , Feng Mei , Zhang Xuan 
Published: December 2022

Abstract
Background

The change frequency of the ventilator circuit was once thought to be the main cause of ventilator-associated pneumonia (VAP), but recent evidence has shown that it is not strongly relevant to VAP in invasively ventilated patients. However, circuits of noninvasive positive pressure ventilation (NPPV) are still routinely (every 7 days) changed in many hospitals to prevent hospital-acquired pneumonia (HAP) without evidence, which is a heavy economic burden on the health system.

Methods

This is a nonblinded, prospective, randomized controlled multicenter trial. Patients who receive NPPV onset in this hospitalization will be screened for eligibility. A total of 340 eligible participants will be stratified (3:2) in two research sites and will be randomly allocated to routine changes in the ventilator circuit group or clinically indicated changes in the circuit group at a ratio of 1:1. Routine prevention for HAP will be provided in both groups. The primary outcome is the occurrence of HAP 48 hrs after NPPV therapy starts or 48 hrs within weaning from NPPV. Secondary outcomes include the length of hospital stay, length of each circuit duration, NPPV treatment days, intubation, mortality and direct cost of the circuits and antibiotics. The growth curve of microorganisms in the ventilator circuit will also be analyzed. It is hypothesized that there will be no difference in the occurrence of HAP in the two arms. Furthermore, a decrease in circuit cost is expected in the intervention group, and the microorganisms in the ventilator circuit are predicted to not increase over time.

Discussion

NPPVs are widely used in patients with various diseases from different healthcare settings. Evidence-based rules for changing NPPV circuits are limited. If supported, our pioneer study will provide a cost-effective NPPV management method without increasing the risks of HAP.
Functional characterization of a Na+/H+ antiporter salt overly sensitive 1 gene, LpSOS1, involved in positively regulating salt response from Lilium pumilum
Authors: Yang Yue , Ming Jun , Xu Leifeng , Li Wenxiang , Cao Yuwei , Bi Mengmeng , Liang Rui , Yang Panpan 
Published: December 2022

Abstract
Lilium pumilum has a strong salt tolerance. However, its molecular mechanisms underlying salt tolerance remain unexplored. In this study, a plasma membrane Na+/H+ antiporter gene, LpSOS1, was cloned from L. pumilum. The expression level of LpSOS1 in L. pumilum was significantly upregulated in the presence of high NaCl concentrations (100 mM). Localisation analysis in tobacco epidermal cells showed that the LpSOS1 protein was found in the plasma membrane. Overexpression of LpSOS1 in Arabidopsis enhanced tolerance to salt stress, as indicated by a lower malondialdehyde content; higher levels of the related antioxidant reductases superoxide dismutase, peroxidase, and catalase; and a decreased Na+/K+ ratio in transgenic plants. SOS1 mutant and wild-type (WT) Arabidopsis plants expressing LpSOS1 grew better, with higher biomass, root length, and lateral root quantity, when treated with NaCl, whereas WT and SOS1 mutant Arabidopsis plants were wilted, chlorotic, and even died under salt stress. Moreover, the transcript levels of stress-related genes were significantly higher in LpSOS1-overexpressing lines than in WT plants under salt stress. These results suggest that LpSOS1 improves plant salt tolerance by regulating ion homeostasis, reducing Na+/K+ in plants, protecting the plasma membrane from oxidative damage under salt stress, and enhancing antioxidant enzyme activity.
Exosomal miR-29a-3p in the immune microenvironment of spleen deficiency promotes hepatocellular carcinoma lung metastasis by activating FAM167A-α1-integrin-NF-κB signaling axis
Authors: Luo Jin , Chen Qiu-Xia , Li Pan , Yang Zhi-Ming , Yu He , Liu Bao-Qi , Fan Mei-Ling , Mo Zhuo-Mao , Wang Yong-Dan , Zhou Mei-Ling , Hu Hao , Yu Ling , Huang Bi-Jun , Zhang Shi-jun 
Published: December 2022

Abstract
Background
Hepatocellular carcinoma (HCC), a common type of cancer, has a strong metastatic ability and poor prognosis. The tumor microenvironment is the “soil” for the occurrence and development of tumors, with exosomes playing an important role in these processes. In traditional Chinese medicine(TCM), the tumor microenvironment corresponds to the internal environment of the syndrome known as spleen deficiency (SD). Numerous studies have shown that exosomes contain high levels of miRNAs, which have been shown to contribute to tumor immune regulation and metastasis. The aim of this study was to explore the mechanisms underlying the changes in the tumor microenvironment under the condition of spleen deficiency in order to find better treatments for cancer.
Methods
The effects of exosomal miR-29a-3p on lung metastasis from hepatocellular carcinoma (HCC) were evaluated using the scratch test, migration test, mouse SD model, HCC model, and tail-vein injection model of lung metastasis. The western blot assay, ELISA, flow cytometry, luciferase reporter gene analysis, qRT-PCR and immunofluorescence staining were among the methods used to study the molecular mechanism of lung metastasis promotion under the SD internal environment.
Results
Compared with the mice with HCC only, the mice with HCC and SD symptoms secreted more miR-29a- 3p-enriched exosomes, and their tumor tissue expressed significantly higher levels of α1-integrin and lower levels of FAM167A. These changed the immune microenvironment of mice (Decreased infiltration of T cells (CD3+CD4+ and CD3+CD8+), activated α1-integrin-NF-κB signaling pathway, and secreted more interleukin inflammatory factors(IL-1β, IL-6, and IL-8), which promoted the invasion and infiltration of HCC and its lung metastasis both in vivo and in vitro. In a series of patients with liver cancer, SD was found to have affected their overall survival and relapse-free survival.
Conclusion
Our study showed that under conditions of SD, the body releases more miRNA-containing exosomes, changes the immune microenvironment of the body, and ultimately promotes tumor metastasis and growth. These results highlight potential therapeutic targets and methods for the prevention of cancer metastasis, which may help to screen possible anticachexia TCMs and elucidate its mechanism in the future.
10-Year-Childhood Malignancy Profile Province-Wide in Indonesia (2009- 2018): Yogyakarta Pediatric Cancer Registry
Authors: Supriyadi Eddy , Purwanto Purwanto , Armytasari Inggar , Ritter Julie , Widjajanto Pudjo Hagung , Veerman AJP 
Published: December 2022

Abstract
Background
This study aims to present an epidemiological profile of childhood malignancies diagnosed in Dr. Sardjito General Hospital from January 2009 to December 2018 and compare it with previous study1.
Methods
Childhood cancer was diagnosed in children aged 0–18 years, from January 2009 to December 2018, and analyzed. Childhood malignancies were categorized based on age, sex, and disease group according to the International Classification of Childhood Cancer. An estimated annual average incidence rate of childhood cancer was calculated. We visualized the number of patients and their regions of origin by geographic mapping.
Results
There were 1,788 new cases registered in Yogyakarta Pediatric Cancer Registry during the study period. The mean age at diagnosis was 6.3 years old with male-to-female ratio 1.4:1.0. Of these 56% of cancers were diagnosed in the age group of 0–5 years old. The most common diagnosis category was leukemia, which accounted for 60% of all childhood malignancies. The three most common diagnoses included: acute lymphoblastic leukemia (44%), acute myeloid leukemia (13%), and retinoblastoma (6%). The annual average incidence rate of leukemia and solid tumors was 26.8 and 17.5 per million, respectively.
Conclusions
There was an increase 60% in the number of childhood malignancies in 2009–2018 compared to the 2000–2009 study. The number of patients referred to our hospital increased, indicating a better registry, better referral system and better access to health care facility due to Universal Health Coverage.
The dermatochalasis of the lower eyelid: A possible aetiology for involutional entropion
Authors: Li Qingji 
Published: December 2022

Abstract
Purpose
To analyze the relationship between dermatochalasis and the orbicularis retaining ligament (ORL) and their effect on involutional entropion.
Methods
Ninety-two eyelids of 68 patients with involutional entropion underwent surgery to remove the prolapsing fat, plicate the lateral canthal tendon or use a lateral tarsal strip procedure, advance the retractor, resect the excess skin with OOM and tighten the OOM by securing the OOM flap to the periosteum, and had a postoperative follow-up of 12 ~ 18 months.
Results
Eighty-eight of 92 eyelids had a satisfactory outcome with normal eyelid positioning and pleasing cosmetic results. Four eyelids showed ectropion, but all of them improved in three months. No recurrence was observed in this study.
Conclusions
The dermatochalasis may be an aetiology of involutional entropion. The relaxed skin could be retracted upward by the ORL, and the skin is then rolled over the superior tarsal border and pressed against the globe. Our procedure addressed most factors and is a useful technique for involutional entropion.
Gut microbiota and acylcarnitine connect the beneficial association between estrogen and lipid metabolism disorders in ovariectomized mice
Authors: Ma Baohua , Zhang Ke , Guo Mengmeng , Cao Xi , Ji De , Xiong Hui , Zhang Ting , Wu Yujiang , Suo Langda , Pan Menghao , Brugger Daniel , Chen Yulin 
Published: December 2022

Abstract
Decreased estrogen levels are one of the main causes of lipid metabolism disorders and coronary heart disease in women after menopause. Exogenous estradiol benzoate is effective to some extent in alleviating lipid metabolism disorders caused by estrogen deficiency, but the role of gut microbes in the regulation process is not yet clear. The objective of this 45 days randomized trial was to investigate the effects of estradiol benzoate supplementation on lipid metabolism, gut microbiota and metabolites in ovariectomized (OVX) mice, and revealing the important role of gut microbes and metabolites in the regulation of lipid metabolism disorders. This study found that high doses of estradiol benzoate supplementation effectively attenuated fat accumulation in OVX mice and significantly altered the expression of genes enriched in hepatic cholesterol metabolism and unsaturated fatty acid metabolism pathways. Further screening of the gut for characteristic metabolites associated with improved lipid metabolism disorders revealed that estradiol benzoate supplementation influences major subsets of acylcarnitine metabolites, and ovariectomy significantly increased the abundance of characteristic microbes that were significantly negatively associated with acylcarnitine synthesis, including Lactobacillus and Eubacterium_ruminantium_group bacteria, while estradiol benzoate supplementation significantly increased the abundance of characteristic microbes that were significantly positively associated with acylcarnitine synthesis, including Ileibacterium and Bifidobacterium bacteria. The use of pseudo-sterile mice gut microbial deficiency greatly facilitates the synthesis of acylcarnitine due to estradiol benzoate supplementation and alleviates lipid metabolism disorders to a greater extent in OVX mice. Our findings established a role for gut microbes in the progression of estrogen deficiency-induced lipid metabolism disorders, and screened for key target bacteria that may have the potential to regulate acylcarnitine synthesis. These findings suggest a possible route for the use of microbe or acylcarnitine to regulate estrogen deficiency-induced disorders of lipid metabolism.
Exploring cognitive and affective outcomes following bilateral 6-hydroxydopamine lesions of the substance nigra or striatum in rats
Authors: Mattos Bianca Andretto , Bonato Jéssica Mendes , Guimarães Elaine Del Bel , Milani Humberto , Oliveira Rúbia Maria Weffort 
Published: December 2022

Abstract
Purpose: The majority of animal models of Parkinson’s disease (PD) focus on motor symptoms that are induced by unilateral injections of such neurotoxins as 6-hydroxydopamine (6-OHDA) in nigrostriatal dopaminergic pathways. However, motor changes that are induced by unilateral 6-OHDA injections may interfere with the identification of cognitive and affective dysfunction induced by dopaminergic neurodegeneration.
Material and Methods: To select an appropriate method for studying nonmotor symptoms of PD and potential neuroprotective treatments, the present study compared behavioral effects of bilateral 6-OHDA infusions directly in the substantia nigra pars compacta (SNpc) or striatum in rats. A battery of behavioral tests, including affective and cognitive tasks, was performed for 22 days after nigrostriatal lesions.
Results:The massive degeneration of tyrosine hydroxylase-immunoreactive neurons was observed in the SNpc, striatum, and ventral tegmental area with 6-OHDA infusions in either the SNpc or striatum. With regard to functional outcomes, 6-OHDA infusions in the striatum decreased general exploratory activity 7 days after the lesion. Rats that received 6-OHDA in the SNpc exhibited cognitive impairments and despair-like behavior. A decrease in the number of newborn neurons was found in the hippocampus in rats that received 6-OHDA in the striatum, indicating a decrease in neurogenesis. 6-OHDA infusions in both the SNpc and striatum impacted the maturation of newborn hippocampal neurons.
Conclusions: These results indicate that bilateral injections of 6-OHDA in the SNpc might be appropriate for studying nonmotor symptoms of PD.
Job-shop scheduling problem and its solution method
Authors: Tsirlin A.M. , Balunov A.I. 
Published: December 2022

Abstract
The paper discusses a variation of the job-shop scheduling problem, its formal definition and solution methods. The variation takes into account the schedule of service points and their location. The authors propose an algorithm for solving the problem. The solution is reduced to multiple assignment problem solving using the branch-and-bound method. To determine the optimality criterion, the authors use both lower- and upper-bound estimates.