bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of plasma levels of BDNF in patients with disorder depressive
Authors: Galletta D. , Mazzarino C. , Cusumano G. , Santoro A. 
Published: February 2022

IntroductionAccording to the World Health Organization (WHO, 2017) depressive disorder continues to be the most widespread and growing mental illness in the world, also assumes that in 2020 depression will have a prevalence equal to one in six individuals. Studies of neuroanatomy have highlighted structural alterations in the hippocampus, striatal nuclei and prefrontal cortex in patients with mood disorders. This alteration in depressed patients is closely related to the secretion of neurotrophic factors, in particular there is a reduction in BDNF (Brain Derived Neurotrophic Factor).ObjectivesThe objective of this study is to demonstrate which treatments are effective in reducing depressive symptoms that allow the increase of BDNF and consequently the structural homostaticity of the brain.MethodsWe have selected data from the literature of the last decade, collected on major search engines such as: Google Scholar, Research Gate, PubMed, Ebsco. Articles collected by selecting the following Keyword: depression, BDNF (Brain Derived Neurotrophic Factor), neuroimaging cognitive behavior therapy.ResultsThe results show that in patients treated with a single drug treatment or vagus nerve stimulation, repetitive transcranial magnetic stimulation (Lang et al., 2008) or electroconvulsive therapy had improvements in BDNF levels, although compared to drug treatment there are problems of no responders, no compliance and lack of effectiveness in reducing vulnerability to relapse. In addition, the study has shown that patients treated with cognitive behavioral therapy have reported greater changes in the frontal and temporal cortex reducing both depressive symptoms and the risk of relapse.ConclusionsUnderlines the importance of an integrated approach
Evaluation of the prevalence and risk factors of depression in patients admitted to the CCU of the persian gulf hospital in bandarabbas city
Authors: Seyyedirad N. 
Published: February 2022

IntroductionThe diagnosis of depression and identifying the factors affecting it in patients with high levels of hospitalization is necessary. Evaluating the prevalence of depression in this population is difficult, because some of the symptoms in depression and medical illness are similar and it is probable the diagnosis of depression to be missed in this patients.ObjectivesThe purpose of this study was to investigate the prevalence of depression and factors affecting it in patientsadmitted to the CCU of the Persian Gulf hospital in BandarabbasCity.MethodsThis study was performed on 133 patients admitted to the Persian Gulf Hospital. After obtainingconsent from patients, depression was recorded based on Beck questionnaire (BDI-II). Demographic data was registered from hospital chart review, and patient interview. Chi-Square and Mann-Whitney tests were used to compare the data.ResultsOur results showed that the prevalence of depressionwas significant in CCU patients. 14.3% of CCU patients had moderate to severe depression and 54.59% had mild depression and only 30.8% were normal. Our study also demonstrated that there was a direct and significant relationship between depression and age, low education level, unemployment and length of hospitalization. (P <0.05)ConclusionsConsidering the high prevalence of depression in CCU patients, it is necessary to identify and perform therapeutic measures in patients at high risk for mental illness.
Depression during the COVID-19 pandemic. A retrospective study on depressive disorders among psychiatric patients admitted at “elisabeta doamna” hospital galati, romania
Authors: Mihailov O. , Rădulescu I.D. , Moraru C. , Nechita P. , Ciubară A.B. , Ciubară A. 
Published: February 2022

IntroductionIsolation, life changes and increased stress lead to widespread concerns about the effects of the Covid-19 pandemic on psychiatric patients. The rise in depressive disorders is one of the negative effects associated directly and indirectly to the pandemic.ObjectivesThe purpose of this study was to investigate the impact of the COVID-19 pandemic on the prevalence of depressive disorders among the patients admitted to our hospital. The state of pandemia was declared on the 11th of March but it had already become a main stream media subject in our country at the beginning of the month with real life changes for our citizens.MethodsA retrospective study was performed at the Psychiatric Hospital ‘Elisabeta Doamna’ Galati, using the exact same period, between 01.03 and 30.09, in 2019 and 2020. ICD-10 criteria were used and pacients with either F32.x,F33.x or F38.x as discharge diagnosis were included.ResultsIn total, 7638 cases were admitted during the period in 2019, of which 751 (9,83%) had depressive disorders. In comparison with 2020 where out of 4050 admitted patients, the number had risen to 1034 (25,53%) a net increase in total number of cases by 37.6%.ConclusionsAnalysis of the data shows a 2.5 times increase in the percentage of depressive disorders among our patients. Even taking in account the lower admition rates, we have seen a clear shift in the psychiatric profile of the average pacient and this has to be taken into consideration in the long and short term treatment of any psychiatric patient.
The magnitude of depression in heart failure patients and its association with NYHA class
Authors: Botto J. , Martins S. , Moreira E. , Cardoso J. Silva , Fernandes L. 
Published: February 2022

IntroductionDepression is commonly present among HF patients and is associated with adverse clinical outcomes. However, research regarding its association with New York Heart Association (NYHA) class is still scarce.ObjectivesTo evaluate the presence of depression symptoms in HF outpatients and analyze its association with NYHA class.MethodsThis study is part of a larger research project (Deus Ex-Machina/NORTE-01-0145-FEDER-00026). HF patients were recruited from an outpatient clinic at a University Hospital. Exclusion criteria were: unable to communicate, severe visual acuity deficit or NYHA class IV. Sociodemographic data and NYHA class were registered. The Patient Health Questionnaire-9 (PHQ-9) was used to assess depression, with a score ≥10 indicating clinically relevant depression.ResultsA sample of 136 HF patients was included, with a median age of 59 (range: 24-81) years old, where 66% were men. Almost half of the patients (49%) were in NYHA class II, followed by class I (36%) and class III (15%). The median score of PHQ-9 was 4(range:0-18), with 26% showing clinically relevant depression. PHQ-9 total score was associated with NYHA class (p=0.001), with higher median scores in worse NYHA classes [class I: 3 (IQR: 5.5), class II: 4 (IQR: 8) and class III: 8.5 (IQR:9.3)].ConclusionsIn this study, depression was present in 26% of HF outpatients and was associated with more severe HF symptoms. Consequently, preventing, monitoring, and treating depression in the management of these patients is recommended. Further research is needed for a deeper analysis of this association.
Adaptation of a french e-health tool for suicide prevention in young populations: Modalities and benefits
Authors: Daval L. , Jeannic A. Le , Picot-Ngo C. , Turmaine K. , Chevreul K. 
Published: February 2022

IntroductionFrance’s suicide rate is among the highest in Europe, with the young among the more at risk than others. Several European projects have demonstrated the effectiveness of using e-tools in suicide prevention particularly for hard-to-reach populations. Lessons from StopBlues, an e-health tool (application/website) for suicide prevention in the general population developed in 2018 which was promoted by municipalities and general practitioners, shows the necessity to adapt its content for young people.ObjectivesThe objective is to develop an e-health tool, BlueZberry, for suicide prevention targeting adolescents and young adults with psychological pain by adapting StopBlues and its promotional plan.MethodsThe detailed content of BlueZberry and its promotional plan were determined via a literature review and 26 individual and group interviews with experts and youth with StopBlues as a starting part.ResultsThe literature review and interviews confirmed the need to adapt the tool according to age of the user since the context and source of psychological pain vary rapidly at this time of life. BlueZberry consists of three modules for age groups 12-14, 15-17 and 18-25 years with specific graphics and messages. Its locally organized promotion should include youth hangouts on top of usual places.ConclusionsThis adaptation of StopBlues will reach a larger audience by offering a more suitable solution for this vulnerable population. A web-portal will serve as an entry point for both StopBlues and BlueZberry where users will be redirected to one of the tools/modules according to their profile and respective needs.
Microbiome-metabolomics signature in anorexia nervosa (AN) before and after weight regain
Authors: Marciello F. , Monteleone A.M. , Troisi J. , Cascino G. , Serena G. , Grave R. Dalle , Monteleone P. 
Published: February 2022

IntroductionThe intestinal microbiota has been indicated to have a role in the pathophysiology of AN.ObjectivesAim of this study was to analyze fecal microbiome profiles of AN women before and after weight restoration and to combine them with fecal metabolomic profiles according to a multi-omics approach.MethodsThe gut microbiome and fecal metabolites were characterized in 21 underweight AN women and after weight restoration and compared with those of 20 healthy women. Microbiome data were correlated with the relevant fecal metabolites.ResultsAN subjects showed a decreased intra-individual bacterial richness, an increased Bacteroidetes-to-Firmicutes abundance ratio and significant changes in the relative abundances of several bacteria at different order levels in both the underweight and weight-restored condition compared to healthy women. The untargeted metabolomic procedure allowed the characterization of 224 metabolites involved in energy, lipid and amino acid metabolism. A genetic algorithm identified 49 relevant metabolites. The relationships among these fecal metabolites and bacteria genera showed structures of different complexity in the 3 groups. In particular, a quarter of those relationships showed a divergent direction in the acute phase of AN than in the weight-restored phase or normal controls. Finally, in acute AN 70% of those correlations showed a negative sign suggesting a prevalent metabolites consummation by gut microbiome.ConclusionsOur results provide a picture of the connections between gut bacteria and fecal metabolites in both the acute phase of AN and after short-term weight restoration. Further studies should aim to investigate the significance of gut microbiome perturbations in development and treatment of AN.
Transcranial magnetic stimulation and eating disorders, any efficacy?
Authors: Morais J. , Esteves P. , Fonseca S. 
Published: February 2022

IntroductionEating Disorders (ED) tend to evolve chronically, with resistance to different therapeutic strategies. Chronicity is associated with high mortality rates, so it is necessary to study new therapeutic strategies. Transcranial Magnetic Stimulation (TMS) is a non-invasive, safe treatment method, whose application has been studied in several pathologies.ObjectivesDetermine the therapeutic potential of Transcranial Magnetic Stimulation in the treatment of Eating Disorders.MethodsBibliographic review of the literature published in English in the last 10 years, in the databases Pubmed, PsycINFO and Cochrane. The keywords used were: TMS, Transcranial Magnetic Stimulation, Eating Disorder, Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder. A review of the titles and abstracts of the resulting articles was made, and selected according to their relevance to the study.ResultsEighteen articles related to the treatment of ED with TMS were selected, either as primary or secondary outcome, of which six were review articles, ten were randomized controlled trials (RCT), one article was an oral communication and another article was a case report. Three RCTs showed improvement in bulimia nervosa, specifically in symptoms of “food craving”. Four RCT and one case report showed improvement in the symptoms of anorexia nervosa, one RCT showed no improvement in anorexia nervosa.ConclusionsTMS appears to have some therapeutic potential for the treatment of ED, particularly in reducing food craving, despite some contradictory results. This work reinforces the need for more robust studies to evaluate the effectiveness of TMS, preferably randomized, with a longer follow-up and a cost-benefit analysis.
Preliminary findings of a longitudinal follow-up study of the paediatric population and their families during and after the coronavirus pandemic and the confinement
Authors: Gindt M. , Fernandez A. , Battista M. , Richez A. , Nachon O. , Askenazy F. 
Published: February 2022

IntroductionPandemic are known to generate traumatic events, such as job losses or violence [1]. Several studies have shown that epidemics and related health measures (quarantine, confinement) lead to an increase of acute stress disorders (ASD), post-traumatic stress disorders (PTSD), anxiety and depression in the adult population [2]. In the pediatric population, few studies have been carried out on the psychiatric outcomes during and after epidemics and associated measures [3].ObjectivesThe aim of this study was to explore ASD symptoms during stay-at-home and Covid 19 pandemic and its impact on children and adolescent mental health.MethodsSixty participants (53% girls and 47% boys; mean age= 9 years 5 months) were included in this longitudinal study [4]. The measures consist in an emergency semi-directed interview designed to assess symptoms of ASD according to the age of children.ResultsPatients’ age modulated psychiatric outcomes. Children under the age of six shown more developmental regressions and more restlessness than older ones. Children from 6 to 12 years were characterized by more oppositional behaviors than adolescents. Finally, adolescents were characterized by more social isolation than younger ones. Other symptoms appear to be more stable across ages: sleep disturbance, fear behavior and somatization.ConclusionsYoung children experienced more externalized symptoms (opposition and agitation) and developmental regressions than older children [5]. Thus, it appears necessary during pandemic to take into account the psychiatric consequences of confinement to reduce psychosocial long-term outcomes in particular in younger patients who appeared to develop specific and age-related psychiatric disorders.
Access to E.D. for mental disorders during the first pandemic wave of 2019 coronavirus epidemic (CoViD-19): Presentation and severity at a lombardy ED
Authors: Savioli G. , Pesenti S. , Ceresa I. , Oddone E. , Bressan M.A. 
Published: February 2022

IntroductionThe 2019 coronavirus epidemic (CoViD-19) in Italy originated in Lombardy, on February 21, 2020. The Fondazione IRCCS Policlinico San Matteo di Pavia has been involved in the management of the outbreak since its beginning. ED’ psychiatric population is considered fragile, at risk of under triage.ObjectivesWe evaluated all the population who went to the ED for mental disorder to assess the severity of cases evaluated as exit code and rate of hospitalization.MethodsWe evaluated all patients accessing our ED for mental disorder from February 22 to May 1, 2020 and during the same period of the previous year.ResultsWe enrolled 345 patients. There was a severe reduction in the total number of accesses for mental disorder: 142 in the CoViD period and 203 in 2019. The vital parameters, age (mean about 40 years) and sex were overlapping without statistically significant differences. The priority codes for the medical examination were not different. CoViD pandemic patients have higher discharge severity codes (yellow and red) more frequently than in the reference period (9.9% vs 5.9%) and more frequently need hospitalization (25.3% vs 18.6%).ConclusionsThe epidemic has led to a reduction of accesses for mental disorder. Patients had more frequent hospitalization needs and more severe exit codes. the data may be due to the fact that during the pandemic only the most serious patients access the E.D., but also to the fact that a pandemic has contributed to destabilizing this class of fragile patients.
• Impact of relative mental illness on caregivers
Authors: Kazakova O. , Thomas F. , Zrazikova V. 
Published: February 2022

IntroductionBelarus is undergoing legislative shifts towards community-based mental health care. Responding effectively to support this process requires an understanding of the experiences and challenges facing families caring for a relative affected by mental illness.ObjectivesTo identify how caring for a person with severe mental illness impacts on family carers, and what carers identify as their support needs.MethodsSemi-structured interviews were undertaken with 17 caregivers of people affected by severe mental illness (diagnosis of F06.8, F20, F25, F7, and/or F 84) in Belarus between March - June 2019.ResultsCare-giving for a family member was usually undertaken on a full time basis with no option for respite. Whilst caring did, in cases, strengthen family solidarity, it also resulted in intensive stress and burnout, financial pressures, and high levels of family tension, exacerbated when the person living with mental illness was perceived as a potential safety risk. High levels of societal stigma meant that care-givers commonly felt unable to discuss their circumstances, travel in public spaces, or participate in community activities. Stigma also deterred carers from seeking professional support. Priorities for support amongst carers included better information, public awareness raising and sensitization, advocacy to support patient integration into social and economic life, peer support and respite for family carers, and an increase in mental health specialists.ConclusionsCaregiving affected family carers on multiple levels with predominantly negative consequences. Priorities identified by carers need to be considered and acted upon if community-based care is to become an effective option.
Cross-ancestry Genome-wide Association Studies of Sex Hormone Concentrations in Pre- and Postmenopausal Women
Authors: Haas Cameron B , Hsu Li , Lampe Johanna W , Wernli Karen J , Lindström Sara 
Published: February 2022

Abstract

Objective
Concentrations of circulating sex hormones have been associated with a variety of diseases in women and are strongly influenced by menopausal status. We investigated the genetic architectures of circulating concentrations of estradiol, testosterone, and SHBG by menopausal status in women of European and African ancestry.

Methods
Using data on 229 966 women from the UK Biobank, we conducted genome-wide association studies (GWASs) of circulating concentrations of estradiol, testosterone, and SHBG in premenopausal and postmenopausal women. We tested for evidence of heterogeneity of genetic effects by menopausal status and genetic ancestry. We conducted gene-based enrichment analyses to identify tissues in which genes with GWAS-enriched signals were expressed.

Results
We identified 4 loci (5q35.2, 12q14.3, 19q13.42, 20p12.3) that were associated with detectable concentrations of estradiol in both pre- and postmenopausal women of European ancestry. Heterogeneity analysis identified 1 locus for testosterone (7q22.1) in the CYP3A7 gene and 1 locus that was strongly associated with concentrations of SHBG in premenopausal women only (10q15.1) near the AKR1C4 gene. Gene-based analysis of testosterone revealed evidence of enrichment of GWAS signals in genes expressed in adipose tissue for postmenopausal women. We did not find any evidence of ancestry-specific genetic effects for concentrations of estradiol, testosterone, or SHBG.

Conclusions
We identified specific loci that showed genome-wide significant evidence of heterogeneity by menopausal status for testosterone and SHBG. We also observed support for a more prominent role of genetic variants located near genes expressed in adipose tissue in determining testosterone concentrations among postmenopausal women.
Donor-π-Acceptor Type Porphyrin-Fullerene Dyad with Acetylene Bridge for p-Type Dye-sensitized Solar Cell
Authors: Guo Qi , Higashino Tomohiro , Kato Kosaku , Yamakata Akira , Imahori Hiroshi 
Published: February 2022

Abstract
Donor-π-acceptor type porphyrin-fullerene dyads with an acetylene bridge were designed and synthesized. The dyad was found to produce a charge-separated state with a lifetime of 0.42 µs and a quantum yield of 0.78 in benzonitrile. The p-type dye-sensitized solar cells with the dyad exhibited higher photovoltaic performance than that with the porphyrin reference without the fullerene moiety.
Resistance Training to Failure: A Science-to-Practice Guide for the Fitness Professional
Authors: Mang Zachary , Rasinski Katarina , Kravitz Len 
Published: February 2022

Apply It!
• In the case of both low- and high-intensity resistance training (RT), fitness professionals should teach their clients to lift near failure without achieving complete momentary muscular failure (MMF), as indicated by a ratings of perceived exertion value of 8 to 9 or repetitions in reserve value of 1 to 2.
• MMF and volitional interruption (VI) elicit comparable improvements in strength and hypertrophy at high intensities (75% to 85% 1RM), so both may be integrated into a single training session (i.e., 4 sets of bench press, first three performed to VI, final set to MMF).
• Program failure training to align with your client's goals — performing RT sets to failure — may be more effective for hypertrophy, whereas nonfailure sets may be more beneficial for power.
Chinese Asset Managers’ Monetary Policy Forecasts and Fund Performance
Authors: Ammer John , Rogers John , Wang Gang , Yu Yang 
Published: February 2022

Although many central banks in the 21st century have become more transparent, Chinese monetary policy communications have been relatively opaque, suggesting that financial market participants must commit significant resources to predicting the central bank’s actions. We conduct a novel systematic textual analysis of the discussion in the quarterly reports of China fund managers, from which we infer their near-term expectations for monetary policy. We construct an aggregate index of manager expectations and show that, as a forecast of Chinese monetary policy, it compares favorably with both market- and model-based alternative projections. We also show that fund managers act on these expectations and correctly anticipating shifts in Chinese monetary policy improves fund performance. Our results imply that manager skill is an important determinant of fund returns, providing the first evidence from China on a question for which studies of asset management in other countries have reached conflicting conclusions. Finally, we find that expectations are more accurate for funds that commit more analytical resources, have higher management fees, or have stronger managerial educational background.This paper was accepted by Victoria Ivashina, finance.Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4330 .