bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of polydopamine coated multi‐walled carbon nanotube on the wettability of sulfonated poly(ether ether ketone) nanocomposite as a proton exchange membrane
Authors: Esmaeilzadeh Zahra , Karimi Mohammad , Mousavi Shoushtari Ahmad , Javanbakht Mehran 
Published: January 2022

AbstractIn the present study, the effect of polydopamine coated multi‐walled carbon nanotube (PCNT) on the surface properties ‐wettability and surface free energy (SFE)‐ of a proton exchange membrane (PEM) nanocomposite based on sulfonated poly(ether ether ketone) (SPEEK) was studied. First, the polydopamine (PDA) coating process was optimized based on a response surface methodology (RSM), then PCNTs and the prepared PEM nanocomposites were characterized using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), UV–vis spectroscopy, X‐Ray diffraction (XRD), differential scanning calorimetry (DSC), and atomic force microscopy (AFM) analyses. The physicochemical properties of membranes were also studied. The surface properties of PEMs were evaluated through estimating the SFE based on Owens, Wendt, Rabel, and Kaelble (OWRK) and Kwok and Neumann (K&N) theories; the SFE data revealed that OWRK is a more reliable method in this respect. Interestingly, the total SFE of SPEEK/PCNT nanocomposite did not notably change compared to the SPEEK membrane, but the polarity of SPEEK/PCNTs significantly decreased from 32.1% in SPEEK to 3.8% in the nanocomposite. This result could be attributed to the acid–base interaction of nanofiller and polymer, resulting in the involvement of polar group of polymer and new orientation of SPEEK chains at the surface of the nanocomposite.
Water soluble photocurable carboxymethyl cellulose‐based bioactive hydrogels for digital light processing
Authors: Zhang Jiancheng , Huang Da , Liu Shuifeng , Yang Zijun , Dong Xianming , Zhang Hongwu , Huang Wenhua , Zhou Shuzhen , Wei Yen , Hua Weijian , Jin Yifei , Zhou Wuyi , Zheng Wenxu 
Published: January 2022

AbstractThe development of light‐based three‐dimensional (3D) printing has changed the manufacturing processes from various materials. The advantages of printing using customized materials are gradually highlighted due to excellent and reliable precision, high repeatability, and wide range of build materials, which enable customized materials to be use in aerospace, biomedical, engineering, and other fields. Due to the existence of acrylate group or epoxy group, most of the commonly used photoactive macromolecules have the main limitations of poor water solubility and/or high biological stimulation, severely constraining the widespread application of these materials in biomanufacturing. To overcome these challenges, a natural hydrogel was modified in this study to achieve a new photocurable material with good biocompatibility and photocrosslinking activity. In particular, methacrylate‐carboxymethyl cellulose (Me‐CMC) was esterified by hydroxyl groups on the long chains of CMC, and hydroxyethyl methacrylate (HEMA)/acrylamide (Am) was added as the crosslinking reaction point between the long molecular chains. Thus, networked structures of this biocompatible material can be formed by photo crosslinking in digital light processing (DLP). The developed composite hydrogel can facilitate the rapid prototyping and high precision manufacturing. The mechanical toughness, swelling property, and microstructures of the composite hydrogel were tunable by changing HEMA/Am content. In addition, it was found that cell survival rate of this photocurable composite hydrogel was good by culturing bone marrow stromal cells (BMSCs) with the material and, cells proliferated significantly in a short time (7 days), which proved the biocompatibility of the proposed material.
Industrial‐scale vacuum casting with silicone molds: A review
Authors: Wortmann Martin , Frese Natalie 
Published: January 2022

AbstractVacuum casting (VC) of reactive polymer resins in silicone molds is one of the oldest rapid tooling methods. It is widely used in the industry for prototype and small‐series production of thermoset plastic parts. Despite its widespread use, its scientific exploration is still scarce compared to other prototyping methods, such as three‐dimensional (3D) printing. Compared to conventional 3D printing methods, a wide range of excellent material properties can be achieved, making it well suited for the production of functional prototypes and even final products. The properties of the thermosets are comparable to those of injection molding in terms of viable shapes, mold fidelity, and material properties. However, due to the high cycle time and limited service life of the molds, VC is rarely utilized for mid‐ or large‐series production. Here, we provide a comprehensive overview of the state of the art and recent advances in the field. The review also provides a detailed technical introduction to the mold production, the process flow, and the materials used. A particular focus is on the key challenges facing industrial‐scale VC today—how to reduce cycle time, and how to increase mold service life?
Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence, and Inflammation via Toll‐like Receptor 4, Reactive Oxygen Species, and p38 MAPK Signaling
Authors: Tong Mancy , Kayani Teimur , Jones Deidre M. , Salmon Jane E. , Whirledge Shannon , Chamley Lawrence W. , Abrahams Vikki M. 
Published: January 2022

ObjectiveMiscarriage affects 1 in 7 pregnancies, and antiphospholipid autoantibodies (aPLs) are one of the biggest risk factors for recurrent pregnancy loss. While aPLs target the endometrial stroma, little is known about their impact. Endometrial stromal cells (EnSCs) undergo decidualization each menstrual cycle, priming the uterus to receive implanting embryos. Thus, appropriate decidualization and EnSC function is key for establishment of a successful pregnancy. This study was undertaken to explore the effects of aPL on EnSC decidualization, senescence, and inflammation.MethodsEnSCs under decidualizing conditions were exposed to aPL or control IgG alone or in the presence of either a Toll‐like receptor 4 (TLR‐4) antagonist, a p38 MAPK inhibitor, a reactive oxygen species (ROS) inhibitor, low molecular weight heparin (LMWH), or acetyl salicylic acid. Secretion of decidualization markers and inflammatory interleukin‐8 were quantified by enzyme‐linked immunosorbent assay, and senescence‐associated β‐galactosidase activity was evaluated. In a mouse model of decidualization, aPL or control IgG was administered, and uterine expression levels of decidualization and inflammatory markers were quantified by real‐time quantitative polymerase chain reaction.ResultsAntiphospholipid antibodies increased human EnSC decidualization, senescence, and inflammation. This phenotype was recapitulated in the mouse model. The decidualization and inflammatory responses were partially mediated by TLR‐4 and p38 MAPK, while the decidualization and senescence responses were ROS‐dependent. LMWH, commonly used to treat aPL‐positive women at risk of obstetric complications, reduced the ability of aPL to increase EnSC decidualization and inflammation.ConclusionThese findings shed new light on the pathogenesis of pregnancy complications in women with aPLs and underscore the benefit of heparin in preventing pregnancy loss in this high‐risk population.
Development of silica‐coated rare‐earth doped strontium aluminate toward superhydrophobic, anti‐corrosive and long‐persistent photoluminescent epoxy coating
Authors: Al‐Qahtani Salhah D. , Snari Razan M. , Alkhamis Kholood , Alatawi Nada M. , Alhasani Mona , Al‐nami Samar Y. , El‐Metwaly Nashwa M. 
Published: January 2022

AbstractLong‐persistent phosphorescent smart paints have the ability to continue glowing in the dark for a prolonged time period to function as energy‐saving products. Herein, new epoxy/silica nanocomposite paints were prepared with different concentrations of lanthanide‐doped aluminate nanoparticles (LAN; SrAl2O4:Eu2+,Dy3+). The LAN pigment was firstly coated with silicon dioxide (SiO2) utilizing the heterogeneous precipitation technique to provide LAN‐encapsulated between SiO2 nanoparticles (LAN@SiO2). The epoxy/silica/lanthanide‐doped aluminate nanoparticles (ESLAN) nanocomposite paints were coated on steel. The prepared ESLAN paints were studied by transmission electron microscopy (TEM), Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X‐ray fluorescence (XRF) analysis, and energy‐dispersive X‐ray spectroscopy (EDS). The transparency and coloration properties of the nanocomposite coated films were explored by CIE Lab parameters and photoluminescence spectra. The ultraviolet‐induced luminescence properties of the transparent coated films demonstrated greenish phosphorescence at 518 nm upon excitation at 368 nm. Both hardness and hydrophobic activities were investigated. The anticorrosion activity of the nanocomposite films coated onto mild steel substrates immersed in aqueous sodium chloride (NaCl(aq)) (3.5%) was studied by electrochemical impedance spectroscopy (EIS). The silica‐containing coatings were monitored to exhibit anticorrosion properties. Additionally, the nanocomposite films with LAN@SiO2 (25%) exhibited the optimized long‐lasting luminescence properties in the dark for 90 min. The nanocomposite films showed highly reversible and durable long‐lived phosphorescence.
Liquid crystal‐based elastomers in tissue engineering
Authors: Gurboga Berfin , Tuncgovde Ebru B. , Kemiklioglu Emine 
Published: January 2022

AbstractLiquid crystal elastomers (LCEs) play role in tissue engineering investigations, with the combination of orientational ordering generated by liquid crystal (LC) moieties and the elastic capabilities of polymers. Liquid crystal‐based polymer materials require a thorough understanding of their features that set them apart from other smart materials for proper design and application. LCEs offer many advantages for their widespread use in the field of biomaterials, by virtue of their simplicity of processing, anisotropic behavior, and responding to numerous external stimuli. Especially, LCEs have widespread usage in bioengineering applications such as scaffolds due to their biocompatibility, viability, and proliferation properties of these materials. This study introduces a brief overview of the new areas of liquid crystal‐based elastomer applications combining both biomaterials and engineering.
Implementation and evaluation of a juvenile mental health training for law enforcement in a medium‐sized jurisdiction
Authors: Brady Caitlin M. , Childs Kristina K. 
Published: January 2022

AbstractThe need for specialized training programs that are focused on youth mental health needs, awareness of community‐based services, and de‐escalation skills is growing across law enforcement agencies due to calls for service that involve youth in mental health crisis. The current study evaluates a juvenile mental health training for law enforcement that was developed based on agency needs. The training was completed by 159 officers and a pre‐/post‐test design was used. Findings suggest that officers were satisfied with the training and improvements were seen across several training constructs (confidence, preparedness, stigma, resource awareness, and de‐escalation skills). Satisfaction with the training predicted change in confidence and preparedness. Recommendations for future research and the implementation of juvenile mental health trainings are discussed.
Suicidal ideation in offenders convicted of child sexual exploitation material offences
Authors: Steel Chad M. S. , Newman Emily , O’Rourke Suzanne , Quayle Ethel 
Published: January 2022

AbstractUnderstanding the prevalence of suicidal ideation in Child Sexual Exploitation Material (CSEM) offenders and their psychological concerns provides the basis for early treatment and intervention. This research solicited responses (n = 78) via an anonymous, web‐based survey from adults in the United States previously convicted of CSEM offences. Significant suicidal ideation was present in 73% of respondents (n = 57), and 19% (n = 15) reported attempting suicide after they were made aware of an investigation, with 41% (n = 32) stating they would have been likely to seek counselling if provided a contact. Most of the respondents felt they were not treated with fairness, understanding, and compassion by investigators, and that their primary psychological strains were going to jail and their families finding out. This research highlights the need for more empathetic investigative approaches, as well as the need for more rapid assessment and treatment of proximal suicide risk in this population.
A B‐Raf V600E gene signature for melanoma predicts prognosis and reveals sensitivity to targeted therapies
Authors: Yao Kevin , Zhou Emily , Cheng Chao 
Published: January 2022

AbstractBackgroundB‐Raf V600E mutations account for about half of all skin cutaneous melanoma cases, and patients with this mutation are sensitive to BRAF inhibitors. However, aberrations in other genes in the MAPK/ERK pathway may cascade a similar effect as B‐Raf V600E mutations, rendering those patients sensitive to BRAF inhibitors. We rationalized that defining a signature based on B‐Raf pathway activity may be more informative for prognosis and drug sensitivity prediction than a binary indicator such as mutation status.MethodsIn this study, we defined a B‐Raf signature score using RNA‐seq data from TCGA. A higher score is shown to not only predict B‐Raf mutation status, but also predict other aberrations that could similarly activate the MAPK/ERK pathway, such as B‐Raf amplification, RAS mutation, and EGFR amplification.ResultsWe showed that patients dichotomized by the median B‐Raf score is more significantly stratified than by other metrics of measuring B‐Raf aberration, such as mutation status, gene expression, and protein expression. We also demonstrated that high B‐Raf score predicts higher sensitivity to B‐Raf inhibitors SB590885 and PLX4720, as expected, but also correlated with sensitivity to drugs targeting other relevant oncogenic pathways.ConclusionThe BRAF signature may better help guide targeted therapy for melanoma, and such a framework can be applied to other cancers and mutations to provide more information than mutation status alone.
Glycan signatures for the identification of cisplatin‐resistant testicular cancer cell lines: Specific glycoprofiling of human chorionic gonadotropin (hCG)
Authors: Hires Michal , Jane Eduard , Kalavska Katarina , Chovanec Michal , Mego Michal , Kasak Peter , Bertok Tomas , Tkac Jan 
Published: January 2022

AbstractBackgroundTesticular cancer (TC) is the most frequent type of cancer among young men aged between 15 and 34 years. TC is treated using cisplatin, but 3%–5% of TC patients fail to respond to cisplatin, with a very bad to fatal prognosis. Accordingly, it is most important to quickly and readily identify those TC patients who are resistant to cisplatin treatment.MethodsThis study seeks to investigate changes in the glycosylation associated with cisplatin resistance to TC cell lines.ResultsA specific glycoprofiling of human chorionic gonadotropin (hCG) was analysed in three TC cell lines and one cell line of female origin. A typical calibration curve for hCG glycoprofiling showed a dynamic range up to 50 ng/ml, with a limit of detection of 0.3 ng/ml and assay reproducibility represented by relative standard deviation of 3.0%. Changes in the glycan signatures on hCG were analysed in cisplatin‐sensitive cell lines and in their cisplatin‐resistant sub‐lines using an enzyme‐linked lectin assay (ELLA) protocol. An immobilised antibody was applied to a selective capture of hCG from a cytoplasmic fraction of cell lysates with final incubation using a lectin from a panel of 17 lectins.ConclusionThe results suggest that one particular lectin Dolichos biflorus agglutinin (DBA) can selectively discriminate sensitive TC cell lines from resistant TC cell lines. Moreover, there are additional lectins which can provide useful information about the strength of cisplatin resistance.
Therapists’ experience of climate change: A dialectic between personal and professional
Authors: Silva Jules F. B. , Coburn Jennifer 
Published: January 2022

AbstractBackgroundHumankind is facing extraordinary existential uncertainties. Therapists are mobilised with urgency in response to the emotional and psychological needs of clients at the onset of the COVID‐19 global pandemic. At the same time, individuals and communities have been and are ever‐increasingly impacted by the seemingly inexorable climate and biodiversity crisis, yet the response of the profession is negligible.ObjectiveTo explore therapists’ experiences of climate change, particularly the dialectic between the ‘personal’ and the ‘professional’ and its implications for professional practice.MethodEight therapists participated in semi‐structured, qualitative interviews. Verbatim transcripts and emergent themes were then subjected to interpretative phenomenological analysis (IPA) using a pluralistic theoretical frame including existential, psychoanalytic and psychosocial thinking.ResultsIt was found that therapists’ personal experiences of climate change were complex and profound, as were their clients'. Therapists’ sense of feeling ill‐equipped to support clients in the climate crisis was indicated.ConclusionFindings suggest it is imperative that professional bodies and training institutions provide leadership and guidance to therapists that enables them to support clients, and themselves, facing potentially dire climate crisis realities. The present study points to a need for professional practice and the work with clients ‘in the room’, therapeutically, to incorporate attention to existential concerns and unconscious processes, by necessity underpinned by therapists’ self‐awareness of their own processes existing in parallel with the clients'. This study also strongly indicated the need to conceptualise clients and therapy itself within social, economic, cultural and political contexts.
Selective Disruption of Survivin's Protein‐Protein Interactions: A Supramolecular Approach Based on Guanidiniocarbonylpyrrole
Authors: Aschmann Dennis , Vallet Cecilia , Tripathi Sunil K. , Ruiz‐Blanco Yasser B. , Brabender Max , Schmuck Carsten , Sanchez‐Garcia Elsa , Knauer Shirley K. , Giese Michael 
Published: January 2022

AbstractTargeting specific protein binding sites to interfere with protein‐protein interactions (PPIs) is crucial for the rational modulation of biologically relevant processes. Survivin, which is highly overexpressed in most cancer cells and considered to be a key player of carcinogenesis, features two functionally relevant binding sites. Here, we demonstrate selective disruption of the Survivin/Histone H3 or the Survivin/Crm1 interaction using a supramolecular approach. By rational design we identified two structurally related ligands (LNES and LHIS), capable of selectively inhibiting these PPIs, leading to a reduction in cancer cell proliferation.
Safety and efficacy of drug‐coated balloon for peripheral artery revascularization—A systematic review and meta‐analysis
Authors: Ullah Waqas , Zghouzi Mohammad , Sattar Zeeshan , Ahmad Bachar , Zahid Salman , Suleiman Abdul‐Rahman M. , Sattar Yasar , Khan Muhammad Zia , Paul Timir , Bagur Rodrigo , Qureshi Mohammad Imran , Fischman David L. , Banerjee Subhash , Prasad Anand , Alraies M. Chadi 
Published: January 2022

AbstractBackgroundThe relative merits of the drug‐coated balloon (DCB) versus uncoated balloon (UCB) angioplasty in endovascular intervention for patients with symptomatic lower extremity peripheral arterial disease (PAD) remains controversial.MethodsOnline databases were queried with various combinations of keywords to identify relevant articles. Net adverse events (NAEs) and its components were compared using a random effect model to calculate unadjusted odds ratios (ORs).ResultsA total of 26 studies comprising 26,845 patients (UCB: 17,770 and DCB: 9075) were included. On pooled analysis, DCB was associated with significantly lower odds of NAE (OR: 0.47, 95% confidence interval [CI]: 0.36–0.61), vessel restenosis (OR: 0.46, 95% CI: 0.37–0.57), major amputation (OR: 0.68, 95% CI: 0.47–99), need for repeat target lesion (OR: 0.38, 95% CI: 0.31–0.47) and target vessel revascularization (OR: 0.62, 95% CI: 0.47–0.81) compared with UCB. Similarly, the primary patency rate was significantly higher in patients undergoing DCB angioplasty (OR: 1.44, 95% CI: 1.19–1.75), while the odds for all‐cause mortality (OR: 0.96, 95% CI: 0.85–1.09) were not significantly different between the two groups. A subgroup analysis based on follow‐up duration (6 months vs. 1 vs. 2 years) followed the findings of the pooled analysis with few exceptions.ConclusionsThe use of DCB in lower extremity PAD intervention is associated with higher primary patency, lower restenosis, lower amputation rate, and decreased need for repeat revascularization with similar all‐cause mortality as compared to UCB.
Compound blue nevus: A misleading pigmented melanocytic tumor
Authors: Baklouti Massara , Sellami Khadija , Elleuch Neila , Rekik Mariem , Saguem Ines , Kamoun Chahir , Gouiaa Naourez , Ben Messaoud Hela , Karray Fathi , Abdelmoula Mohamed , Sellami Tahia , Turki Hamida 
Published: January 2022

AbstractCompound blue nevus had clinical and histological similarities with other heavily pigmented melanocytic tumor, like the pigmented epithelioid melanocytoma. Distinctive genomic aberrations have allowed differentiating it. The defining characteristic of blue nevi family is the presence of activating mutations in the G protein α‐subunits, GNAQ and GNA11.
Palladium‐Catalyzed Cascade C−H Functionalization/Asymmetric Allylation Reaction of Aryl α‐Diazoamides and Allenes: Lewis Acid Makes a Difference
Authors: Wu Min‐Song , Ruan Xiao‐Yun , Han Zhi‐Yong , Gong Liu‐Zhu 
Published: January 2022

AbstractA Pd‐catalyzed cascade C−H functionalization/asymmetric allylation reaction with aryl α‐diazoamides and allenes has been developed. The reaction provides an efficient approach to construct chiral 3,3‐disubstituted oxindole derivatives in high levels of yield and enantioselectivity (up to 93 %ee). Notably, the chromium complex works as Lewis acid to facilitate the formation of palladium carbene and to enhance acidity of carboxylic acid, allowing for higher stereochemical control and efficiency.
Simultaneous Organic and Inorganic Host‐Guest Chemistry within Pillararene‐Protein Cage Frameworks
Authors: Shaukat Ahmed , Anaya‐Plaza Eduardo , Beyeh Ngong Kodiah , Kostiainen Mauri A. 
Published: January 2022

AbstractSupramolecular self‐assembly of biomolecules provides a powerful bottom‐up strategy to build functional nanostructures and materials. Among the different biomacromolecules, protein cages offer various advantages including uniform size, versatility, multi‐modularity, and high stability. Additionally, protein cage crystals present confined microenvironments with well‐defined dimensions. On the other hand, molecular hosts, such as cyclophanes, possess a defined cavity size and selective recognition of guest molecules. However, the successful combination of macrocycles and protein cages to achieve functional co‐crystals has remained limited. In this study, we demonstrate electrostatic binding between cationic pillar[5]arenes and (apo)ferritin cages that results in porous and crystalline frameworks. The electrostatically assembled crystals present a face‐centered cubic (FCC) lattice and have been characterized by means of small‐angle X‐ray scattering and cryo‐TEM. These hierarchical structures result in a multiadsorbent framework capable of hosting both organic and inorganic pollutants, such as dyes and toxic metals, with potential application in water‐remediation technologies.