bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification
Authors: Zi Zhenzhen , Zhang Zhuzhen , Feng Qiang , Kim Chiho , Wang Xu-Dong , Scherer Philipp E. , Gao Jinming , Levine Beth , Yu Yonghao 
Published: April 2022

AbstractThe evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell growth and proliferation. mTORC1 is activated on the lysosome surface. However, once mTORC1 is activated, it is unclear whether mTORC1 phosphorylates local lysosomal proteins to regulate specific aspects of lysosomal biology. Through cross-reference analyses of the lysosome proteome with the mTORC1-regulated phosphoproteome, we identify STK11IP as a lysosome-specific substrate of mTORC1. mTORC1 phosphorylates STK11IP at Ser404. Knockout of STK11IP leads to a robust increase of autophagy flux. Dephosphorylation of STK11IP at Ser404 represses the role of STK11IP as an autophagy inhibitor. Mechanistically, STK11IP binds to V-ATPase, and regulates the activity of V-ATPase. Knockout of STK11IP protects mice from fasting or Methionine/Choline-Deficient Diet (MCD)-induced fatty liver. Thus, our study demonstrates that STK11IP phosphorylation represents a mechanism for mTORC1 to regulate lysosomal acidification and autophagy, and points to STK11IP as a promising therapeutic target for the amelioration of diseases with aberrant autophagy signaling.
Quantifying daily rhythms with non-negative matrix factorization applied to mobile phone data
Authors: Aledavood Talayeh , Kivimäki Ilkka , Lehmann Sune , Saramäki Jari 
Published: April 2022

AbstractHuman activities follow daily, weekly, and seasonal rhythms. The emergence of these rhythms is related to physiology and natural cycles as well as social constructs. The human body and its biological functions undergo near 24-h rhythms (circadian rhythms). While their frequencies are similar across people, their phases differ. In the chronobiology literature, people are categorized into morning-type, evening-type, and intermediate-type groups called chronotypes based on their tendency to sleep at different times of day. Typically, this typology builds on carefully designed questionnaires or manually crafted features of time series data on people’s activity. Here, we introduce a method where time-stamped data from smartphones are decomposed into components using non-negative matrix factorization. The method does not require any predetermined assumptions about the typical times of sleep or activity: the results are fully context-dependent and determined by the most prominent features of the activity data. We demonstrate our method by applying it to a dataset of mobile phone screen usage logs of 400 university students, collected over a year. We find four emergent temporal components: morning activity, night activity, evening activity and activity at noon. Individual behavior can be reduced to weights on these four components. We do not observe any clear categories of people based on the weights, but individuals are rather placed on a continuous spectrum according to the timings of their phone activities. High weights for the morning and night components strongly correlate with sleep and wake-up times. Our work points towards a data-driven way of characterizing people based on their full daily and weekly rhythms of activity and behavior, instead of only focusing on the timing of their sleeping periods.
Bladder cancer cells shift rapidly and spontaneously to cisplatin-resistant oxidative phosphorylation that is trackable in real time
Authors: Xu Tong , Junge Jason A. , Delfarah Alireza , Lu Yi-Tsung , Arnesano Cosimo , Iqbal Maheen , Delijani Kevin , Hsieh Tien-Chan , Hodara Emmanuelle , Mehta Hemal H. , Cohen Pinchas , Graham Nicholas A. , Fraser Scott E. , Goldkorn Amir 
Published: April 2022

AbstractGenetic mutations have long been recognized as drivers of cancer drug resistance, but recent work has defined additional non-genetic mechanisms of plasticity, wherein cancer cells assume a drug resistant phenotype marked by altered epigenetic and transcriptional states. Currently, little is known about the real-time, dynamic nature of this phenotypic shift. Using a bladder cancer model of nongenetic plasticity, we discovered that rapid transition to drug resistance entails upregulation of mitochondrial gene expression and a corresponding metabolic shift towards the tricarboxylic acid cycle and oxidative phosphorylation. Based on this distinction, we were able to track cancer cell metabolic profiles in real time using fluorescence lifetime microscopy (FLIM). We observed single cells transitioning spontaneously to an oxidative phosphorylation state over hours to days, a trend that intensified with exposure to cisplatin chemotherapy. Conversely, pharmacological inhibition of oxidative phosphorylation significantly reversed the FLIM metabolic signature and reduced cisplatin resistance. These rapid, spontaneous metabolic shifts offer a new means of tracking nongenetic cancer plasticity and forestalling the emergence of drug resistance.
Radical borylation of vinyl azides with NHC-boranes: divergent synthesis of α-boryl ketones and borylated triazoles
Authors: Zhang Yifei , Liao Yangzhen , Liu Peijun , Ran Yu , Liu Xiaozu 
Published: April 2022

A radical borylation of vinyl azides with NHC-boranes in the presence of tBuSH is described, which enables the divergent synthesis of α-boryl ketones and borylated triazoles with excellent functional group tolerance and a broad substrate scope.
An Introduction to Speech Privacy for Early Career Clinicians: General Considerations and the Specific Example of Electrolarynx Users
Authors: Cox Steven R. , Koenig Laura L. 
Published: April 2022

Purpose:
This article introduces early career clinicians to speech privacy (SP): its definition, a brief history in the context of the Health Insurance Portability and Accountability Act, and applications in health care settings. General considerations for speech-language pathologists (SLPs) are outlined, along with basic principles for considering what might threaten SP. The example of speakers who use an electrolarynx (EL) is used to call attention to some specific issues that clinicians may encounter in trying to maintain SP.

Conclusions:
This article provided an overview of SP considerations for early career clinicians. In the case of EL users, these include the unique quality of EL speech and the settings in which SLPs may work with these patients. More research is needed to investigate SP concerns for specific clinical populations that seek SLP services and the physical conditions in which clinician–client discussions occur. Recommendations for clinical practice are provided.
Optimal distributed generation penetration considering relay coordination and power quality requirements
Authors: Sadeghi Mohammad Hossein , Dastfan Ali , Damchi Yaser 
Published: April 2022

AbstractAlthough the electric energy supply from distributed generation (DG) resources is increasing, these sources also face limitations. Protection and power quality constraints are the most important issues that limit the maximum DG penetration in power systems. Changing the short circuit level due to DGs' presence—especially synchronous‐based (SDG) type—may lead to miscoordination of the protective relays. Also, standard harmonic limits may be violated due to harmonic injection of inverter‐based DGs and non‐linear loads. A protection coordination problem is solved for the basic configuration, and the optimal settings are applied. Then, using a proposed approach and a new objective function, the location, size, and type of DGs are optimized to maximize the DG penetration and the speed of protection system, while reducing power losses. Finally, the protection setting of SDGs is optimized and applied. In these optimizations, the protection coordination constraints and the power quality requirements are considered and met. IEEE 14‐bus system and a real sub‐transmission system are simulated to evaluate the proposed approach and the new objective function. The obtained results show significant power loss reduction and protection speed improvement for different scenarios and case studies.
The morphology of the HD 163296 jet as a window on its planetary system
Authors: Kirwan A. , Murphy A. , Schneider P. C. , Whelan E. T. , Dougados C. , Eislöffel J. 
Published: April 2022

Context. HD 163296 is a Herbig Ae star which drives a bipolar knotty jet with a total length of ~6000 au. Strong evidence exists that the disk of HD 163296 harbors planets. Studies have shown that the presence of companions around jet-driving stars could affect the morphology of the jets. This includes a ‘wiggling’ of the jet axis and a periodicity in the positions of the jet knots.
Aims. In this study we investigate the morphology (including the jet width and axis position) and proper motions of the HD 163296 jets, and use our results to better understand the whole system.
Methods. This study is based on optical integral-field spectroscopy observations obtained with VLT/MUSE in 2017. Using spectro-images and position velocity diagrams extracted from the MUSE data cube, we investigated the number and positions of the jet knots. A comparison was made to X-shooter data collected in 2012 and the knot proper motions were estimated. The jet width and jet axis position with distance from the star were studied from the extracted spectro-images. This was done using Gaussian fitting to spatial profiles of the jet emission extracted perpendicular to the position angle of the jet. The centroid of the fit is taken as the position of the jet axis.
Results. We observe the merging of knots and identify two previously undetected knots. We find proper motions that are broadly in agreement with previous studies. The jet width increases with distance from the source and we measure an opening angle of ~5° and 2.5° for the red and blue lobes, respectively. Measurements of the jet axis position, derived from Gaussian centroids of transverse intensity profiles, reveal a similar pattern of deviation in all forbidden emission lines along the first 20 arcsec of the jets. This result is interpreted as being due to asymmetric shocks and not due to a wiggling of the jet axis.
Conclusions. The number of new knots detected and their positions challenge the 16-yr knot ejection periodicity proposed in prior studies, arguing for a more complicated jet system than was previously assumed. We use the non-detection of a jet axis wiggling to rule out companions with a mass >0.1 M⊙ and orbits between 1 au and 35 au. Any object inferred at these distances using other methods must be a brown dwarf or planet, otherwise it would have impacted the jet axis position. Both the precession and orbital motion scenarios are considered. Overall it is concluded that it is difficult to detect planets with orbits >1 au through a study of the jet axis.
H2CS deuteration maps towards the pre-stellar core L1544
Authors: Spezzano S. , Sipilä O. , Caselli P. , Jensen S. S. , Czakli S. , Bizzocchi L. , Chantzos J. , Esplugues G. , Fuente A. , Eisenhauer F. 
Published: April 2022

Context. Deuteration is a crucial tool for understanding the complexity of interstellar chemical processes, especially when they involve the interplay of gas-phase and grain-surface chemistry. In the case of multiple deuteration, comparing observation with the results of chemical modelling is particularly effective to study how molecules are inherited in the different stages within the process of star and planet formation.
Aims. We aim to study the D/H ratio in H2CS across the prototypical pre-stellar core L1544. This study allows us to test current gas–dust chemical models involving sulfur in dense cores.
Methods. Here, we present single-dish observations of H2CS, HDCS and D2CS with the IRAM 30 m telescope. We analysed their column densities and distributions and compared these observations with gas–grain chemical models. The deuteration maps of H2CS in L1544 were compared with the deuteration maps of methanol, H2CO, N2H+, and HCO+ towards the same source. Furthermore, we compared the single and double deuteration of H2CS towards the dust peak of L1544 with H2CO and c-C3H2. The difference between the deuteration of these molecules in L1544 is discussed and compared with the prediction of chemical models.
Results. The maximum deuterium fractionation for the first deuteration of H2CS is N(HDCS)/N(H2CS) ~ 30% and is located towards the north-east at a distance of about 10000 AU from the dust peak. While for c-C3H2 the first and second deuteration have a similar efficiency, for H2CS and H2CO the second deuteration is more efficient, leading to D2CX/HDCX ~ 100% (with X = O or S).
Conclusions. Our results imply that the large deuteration of H2CO and H2CS observed in protostellar cores as well as in comets is likely inherited from the pre-stellar phase. However, comparison with state-of-the-art chemical models suggests that the reaction network for the formation of the doubly deuterated H2CS and H2CO it is not complete yet.
Hyperfine-resolved optical spectroscopy of the A2Π ← X2Σ+ transition in MgF
Authors: Doppelbauer M. , Wright S. C. , Hofsäss S. , Sartakov B. G. , Meijer G. , Truppe S. 
Published: April 2022

We report on hyperfine-resolved laser spectroscopy of the A2Π ← X2Σ+ transition of magnesium monofluoride (MgF), relevant for laser cooling. We recorded 25 rotational transitions with an absolute accuracy of better than 20 MHz, assigned 56 hyperfine lines, and determined precise rotational, fine, and hyperfine structure parameters for the A2Π state. The radiative lifetime of the A2Π state was determined to be 7.2(3) ns, in good agreement with ab initio calculations. The transition isotope shift between bosonic isotopologues of the molecule is recorded and compared to predicted values within the Born–Oppenheimer approximation. We measured the Stark effect of selected rotational lines of the A2Π ← X2Σ+ transition by applying electric fields of up to 10.6 kV cm−1 and determined the permanent electric dipole moments of 24MgF in its ground X2Σ+ and first excited A2Π states to be μX = 2.88(20) D and μA = 3.20(22) D, respectively. Based on these measurements, we caution for potential losses from the optical cycling transition due to electric field induced parity mixing in the excited state. In order to scatter 104 photons, the electric field must be controlled to below 1 V cm−1.
The Caputo–Fabrizio time-fractional Sharma–Tasso–Olver–Burgers equation and its valid approximations
Authors: Hosseini Kamyar , Ilie Mousa , Mirzazadeh Mohammad , Baleanu Dumitru , Park Choonkil , Salahshour Soheil 
Published: April 2022

Abstract
Studying the dynamics of solitons in nonlinear time-fractional partial differential equations has received substantial attention, in the last decades. The main aim of the current investigation is to consider the time-fractional Sharma–Tasso–Olver–Burgers (STOB) equation in the Caputo–Fabrizio (CF) context and obtain its valid approximations through adopting a mixed approach composed of the homotopy analysis method (HAM) and the Laplace transform. The existence and uniqueness of the solution of the time-fractional STOB equation in the CF context are investigated by demonstrating the Lipschitz condition for

φ

x
,
t
;
u

as the kernel and giving some theorems. To illustrate the CF operator effect on the dynamics of the obtained solitons, several two- and three-dimensional plots are formally considered. It is shown that the mixed approach is capable of producing valid approximations to the time-fractional STOB equation in the CF context.
Product and sum uncertainty relations based on metric-adjusted skew information
Authors: Ma Xiaoyu , Zhang Qing-Hua , Fei Shao-Ming 
Published: April 2022

Abstract
The metric-adjusted skew information establishes a connection between the geometrical formulation of quantum statistics and the measures of quantum information. We study uncertainty relations in product and summation forms of metric-adjusted skew information. We present lower bounds on product and summation uncertainty inequalities based on metric-adjusted skew information via operator representation of observables. Explicit examples are provided to back our claims.
Algebra of discrete symmetries in the extended Poincaré group
Authors: Dvoeglazov Valeriy V. 
Published: April 2022

Abstract
We begin with the comprehensible review of the basics of the Lorentz, (extended) Poincare Groups and O(3,2) and O(4,1). On the basis of the Gelfand-Tsetlin-Sokolik-Silagadze research [1-3], we investigate the definitions of the discrete symmetry operators both on the classical level, and in the secondary-quantization scheme. We studied the physical content within several bases: light-front form formulation, helicity basis, angular momentum basis, on several practical examples. The conclusion is that we have ambiguities in the definitions of the the corresponding operators P, C; T, which lead to different physical consequences.
Michelson-Morley experiment explained by means of five methods
Authors: Klinaku Shukri 
Published: April 2022

Abstract
The Michelson-Morley experiment (MME) is still important to physics, and not just to the history of physics. The hypothesis of contraction of bodies in the direction of their motion arose as an ad hoc hypothesis about the “contraction” of the Michelson’s interferometer arm in the direction of its motion. Even today this experiment is the “strongest argument” of this hypothesis, and of time dilation too. This work will present the explanation of the MME through five methods. The first method can be called the traditional method, which was applied by Michelson, but not correctly. The other methods are the explanation of the MME with the interferometer located at an acute angle to the direction of Earth’s motion; with the light clock; using Galilean transformation in polar coordinates and using the Doppler effect formula. All these methods give the same solution, and this solution is in accordance with the experiment’s result. Solutions derived from these five methods represent a natural explanation for the result of the MME – without weird terms and without unscientific assumptions.
The universal rewrite system coded
Authors: Rowlands Sydney , Rowlands Peter 
Published: April 2022

Abstract
The universal rewrite system (URS), first formulated by Rowlands and Diaz [2002], which may well be the meta-pattern driving the systems of the physical universe, has been realized, in the companion paper, in the deterministic Turing machine and other devices foundational to computational theory. Here, we show that we can extend the results to actual coding of a given finite section of the fundamentally infinite system. We also apply the principle of the URS to the universal Turing machine and to variable finite automata over an infinite alphabet, and explain its use in cryptography and the decision problem.
Double photon coincidence crosstalk reduction method for multi-nuclide Compton imaging
Authors: Uenomachi M. , Shimazoe K. , Takahashi H. 
Published: April 2022

Abstract
Compton imaging based on Compton scattering kinematics has the potential to visualize multi-nuclides by discriminating the total energy of Compton scattering and photoelectric absorption events. This feature enables us to perform multi-tracer imaging that reflects different functional information in nuclear medicine, resulting in a definitive diagnosis and being useful for biological and medical research. One of the challenges with multi-nuclide imaging is the crosstalk artifacts caused by scattered photons of higher energy gamma-rays. In this study, we investigated the potential benefits of the double photon coincidence detection as a drastic crosstalk reduction method. Coincidence detection of successive gamma-rays can differentiate nuclides and reduce the background caused by other nuclides' gamma-rays because some nuclides emit two or more gamma-rays in rapid succession. In this study, we focused on the coincidence detection of a Compton event and a photoelectric absorption event, and we showed simultaneous double photon emitter imaging of 111In and 177Lu with a ring-type Compton imaging system. The artifacts caused by other nuclides' gamma-rays were reduced by extracting Compton events coincident with photoelectric absorption events. The coincidence Compton images demonstrated a signal-to-background ratio improvement of 1.1–1.7 times over the one of no-coincidence Compton images, despite a drop in intrinsic detection efficiency of the order of 10-2. This strategy of directly reducing crosstalk will be useful in other combinations imaging such as of 111In (or 177Lu) and a positron emission tomography nuclide.
Photovoltaic Panels and Solar Collectors in Cityscape of Bialystok (Poland) and Cordoba (Spain)
Authors: Gawryluk Dorota , Krawczyk Dorota Anna , Rodero Antonio 
Published: April 2022

Abstract
The technologies using of renewable sources energy like photovoltaic panels and solar collectors were used in Europe, mainly in southern countries (like Spain) until recently. EU policy of sustainable development and technological development impact on increase of popularity of those technologies in northern European countries like Poland. The research problem of the work is to determinate the appropriate conditions for the location of above-mentioned technology (panels) in the cityscape. The numerous examples of its destruction were noticed because panels were located using only energy efficiency conditions. The research methodology was based on “in situ” research (Bialystok-Poland, Cordoba – Spain) in order to determinate the categories of urban landscape in which panels are located. Technical, climatic, landscape and composition conditions were analysed in order to establish assessment of completed investments. The result of the science work are categories of the urban landscape views in Bialystok and Cordoba, ie architectural and landscape encloses (streets, squares, public gardens), city panoramas. The proposed methodology of assessment of cityscape impact are applicable to the planning, designing and investment process for Bialystok and Cordoba. They could be used to another cities also in necessary condition of taking into account the individual characteristic of cityscape. The proposed conclusions can be used in the planning, designing and investment process of another cities due to protection of their cityscape values.
The Impact of Urban Green-infrastructure Development on the Price of Surrounding Real Estate: A Case Study of Taichung City’s Central District
Authors: Hsu Kuo-Wei , Chao Jen-Chih 
Published: April 2022

Abstract
Amid increasingly common extreme climate events and urban heat-island effects, cities are at increased risk from a range of natural disasters. Green infrastructure emphasizes coordination and mutual benefit between, on the one hand, human construction and development, and the natural environment on the other, and can be adjusted to mitigate disaster risks. However, in addition to public-sector policies, urban green-infrastructure development requires incentives for private-sector implementation. This study examines the impact on the value of local real estate of three green-infrastructure projects in the Central District of Taichung City, Taiwan, both during and after their construction. Its findings show that green-infrastructure development can indeed drive-up urban real-estate prices, with slightly different rates of increase, according to type of real estate themselves. The knowledge of this dynamic provided by this study should make such development attractive to the private sector, and thus ultimately aid disaster prevention and improve the overall quality of the urban environment.