bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer
Authors: Mallard Joris , Hucteau Elyse , Schott Roland , Trensz Philippe , Pflumio Carole , Kalish‐Weindling Michal , Favret Fabrice , Pivot Xavier , Hureau Thomas J. , Pagano Allan F. 
Published: November 2022

AbstractBackgroundFatigue is a hallmark of breast cancer and is associated with skeletal muscle deconditioning. If cancer‐related fatigue occurs early during chemotherapy (CT), the development of skeletal muscle deconditioning and its effect on exercise capacity remain unclear. The aim of this study was to investigate the evolution of skeletal muscle deconditioning and exercise capacity in patients with early‐stage breast cancer during CT.MethodsPatients with breast cancer had a visit before undergoing CT, at 8 weeks, and at the end of chemotherapy (post‐CT). Body composition was determined through bioelectrical impedance analysis. Knee extensor, handgrip muscle force and fatigue was quantified by performing maximal voluntary isometric contractions and exercise capacity using the 6‐min walking test. Questionnaires were also administered to evaluate quality of life, cancer‐related fatigue, and physical activity level.ResultsAmong the 100 patients, reductions were found in muscle mass (−2.3%, p = .002), exercise capacity (−6.7%, p < .001), and knee extensor force (−4.9%, p < .001) post‐CT, which occurred within the first 8 weeks of treatment with no further decrease thereafter. If muscle fatigue did not change, handgrip muscle force decreased post‐CT only (−2.5%, p = .001), and exercise capacity continued to decrease between 8 weeks and post‐CT (−4.6%, p < .001). Quality of life and cancer‐related fatigue were impaired after 8 weeks (p < .001) and remained stable thereafter, whereas the physical activity level remained stable during chemotherapy.ConclusionsSimilar to cancer‐related fatigue, skeletal muscle deconditioning and reduced exercise capacity occurred early during breast cancer CT. Thus, it appears essential to prevent these alterations through exercise training implemented during CT.
TP53‐altered acute myeloid leukemia and myelodysplastic syndrome with excess blasts should be approached as a single entity
Authors: Shallis Rory M. , Daver Naval G. , Altman Jessica K. , Hasserjian Robert P. , Kantarjian Hagop M. , Platzbecker Uwe , Santini Valeria , Wei Andrew H. , Sallman David A. , Zeidan Amer M. 
Published: November 2022

AbstractTP53‐altered myelodysplastic syndrome with excess blasts and TP53‐altered acute myeloid leukemia should be considered under one unifying classification term for their study in clinical trials. Ultimately, such a unification would simplify the screening processes for clinical trials and allow a focus on treating the patient for a genetically defined disorder rather than one based on an arbitrary blast threshold.
Schema therapy for patients with borderline personality disorder and comorbid alcohol dependence: A multiple‐baseline case series design study
Authors: Boog Michiel , Goudriaan Anna E. , Wetering Ben J. M. v. d. , Franken Ingmar H. A. , Arntz Arnoud 
Published: November 2022

AbstractThis study tested the effectiveness of schema therapy (ST) for borderline personality disorder (BPD) and comorbid alcohol dependence (AD). Twenty patients participated in a case series study with multiple baselines. The baseline phase consisted of treatment as usual. It was followed by a case conceptualization phase, an experiential techniques phase and a behavioural change phase. Patients showed a significant decrease in BPD and AD symptoms; change was mainly accomplished in the experiential techniques phase, with medium to large effect sizes. Three months after termination of therapy, 68% of the patients had remitted from BPD, and the number of drinking days decreased clearly. This study shows that, although treatment is challenging in this group of patients, meaningful change can be obtained in patients with BPD and AD using ST.
A Novel Gel Thermoelectric Chemical Cell for Harvesting Low‐Grade Heat Energy
Authors: Yue Qu , Gao Taotao , Wang Yujue , Meng Yan , Li Xiaoqin , Yuan Hongyan , Xiao Dan 
Published: November 2022

AbstractThe use of gel thermoelectric chemical cells to capture low‐grade heat for conversion to electricity is an attractive approach. However, there are few studies on whether the distribution of redox species in the electrolyte has an effect on the performance of cells. Herein, this concern was discussed by constructing a novel gel thermoelectric chemical cell (Cu−C‐cg). Using cellulose‐like rice paper as a separator, a concentration gradient of electrolyte was carefully constructed, so that the concentration of potassium ferrocyanide gradually decreased from the hot electrode to the cold electrode while the concentration of potassium ferricyanide gradually increased. Through electrochemical measurement and analysis, it was found that the thermoelectric performance of this cell outperformed the cell without electrolyte concentration gradients. Meanwhile, this performance could be enhanced by the use of asymmetric electrodes composed of copper foil and carbon electrodes. After optimizing the conditions, the open‐circuit voltage, output power, and Seebeck coefficient of the Cu−C‐cg cell at 12 K temperature difference were 0.450 V, 183 μW, and 7.82 mV K−1, respectively. This work not only provides a novel idea in gel‐based cell design but also an excellent thermoelectric chemical cell.
DNA image cytometry ploidy analysis technique improves the detection rate of pleural effusion cytology
Authors: Ma Zhenhua , Li Pan , Gai Xiaodong , Li Xingang , Sun Bo , Wang Taisheng , Jiang Pingping , Wang Haitao , Zhang Jihong 
Published: November 2022

AbstractObjectiveTo explore the clinical diagnostic value of DNA image cytometry (DNA–ICM) ploidy analysis in malignant pleural effusion cancer screening, this study analyzed the effect of exfoliated cell smears (ECSs), cell blocks (CBs), and immunochemistry.MethodA total of 830 cases of pleural effusion were considered for the DNA–ICM ploidy analysis. The ECSs were centrifuged, the CBs were formed, and the DNA–ICM ploidy analysis was carried out in the diagnosis of malignant pleural effusion. Immunochemistry and biopsy was applied to differentiate between benign and malignant pleural effusion and to determine the source of the latter. The sensitivity and specificity differences between the three methods alone and in combination were compared.ResultsThe sensitivity of the DNA–ICM, ECS, and CB methods was 96.28%, 94.93%, and 95.95%, respectively, and the specificity of each method was 86.52%, 87.08%, and 86.14%, respectively. The sensitivity and specificity of the combined diagnosis method were 99.32% and 75.09%, respectively. Among the 22 cases diagnosed as positive in the DNA–ICM ploidy analysis but negative in the ECS and CB analyses, four cases were diagnosed as positive by comprehensive clinical diagnosis.ConclusionThe sensitivity and specificity of DNA–ICM ploidy analysis are high; the positive detection rate of pleural fluid cytology is effectively increased, and the missed detection rate of cell pathologies is effectively reduced. The combination of the three methods significantly improves the specificity and sensitivity of the diagnosis of malignant pleural effusion, and immunochemistry with CBs can be used to accurately analyze the primary tumor site.
A synthesis of the external morphology of cypridiform larvae of Facetotecta (crustacea: Thecostraca) and the limits of the genus Hansenocaris
Authors: Kolbasov Gregory A. , Savchenko Alexandra S. , Dreyer Niklas , Chan Benny K. K. , Høeg Jens T. 
Published: November 2022

AbstractAlthough the naupliar and cypridiform stages of the enigmatic y‐larvae of Facetotecta have been found in the marine plankton worldwide, they still represent the last significant group of crustaceans for which the adult forms are still unknown. From a number of y‐cyprids representing different taxa from different locations, we employ scanning electron microscopy to describe fine morphological details of all external structures of this unique larval form. We document different segmentation patterns of the abdomen and presence/absence of the labrum and structural differences in the antennules, labrum, paraocular process, thoracopods, and telson lend support for the erection of several new genera as opposed to the single Hansenocaris. The data presented here emphasize the morphological limits of the genus Hansenocaris and the “bauplan” of cyprydiform larvae of Facetotecta. Although the optimum pathway is a joint analysis of both molecular and morphological characters, we use the morphological characters of y‐cyprids to align them cladistically and determine the limits of the genus Hansenocaris s.s. and describe common characters for all y‐cyprids including six pairs of the lattice organs instead five pairs considered as a ground pattern for all Thecostraca. We also determine plesiomorphic and apomorphic characters of all known y‐cyprids and separate them from other thecostracan cypridiform larvae.
Iridium‐Catalysed C−H Borylation of Fluoroarenes: Insights into the Balance between Steric and Electronic Control of Regioselectivity
Authors: Ding Mingyan , Reuven Jonathan A. , Hones Andrew C. , Fox Mark A. , Steel Patrick G. 
Published: November 2022

AbstractThe iridium catalysed C−H borylation of polyfluorinated arenes and heteroarenes occurs rapidly and efficiently. As with other borylation reactions, whilst steric parameters dominate, an underlying electronic influence on reaction selectivity can be observed. Notably borylation regioselectivity in fluorinated (hetero)arenes is determined by purely electronic effects except for ortho‐borylation between two fluorine atoms where steric effects of fluorine substituents become apparent. Borylation at the para position with respect to fluorine is disfavoured whereas a strong electronic preference for borylation para to the azinyl nitrogen of pyridine is observed. When these features co‐operate high selectivity can be expected. For these reactions, computations based on transition state, rather than intermediate, energies in iridium geometries showed excellent agreement between predicted and observed selectivities.
Enantioselective CE–MS analysis of ketamine metabolites in urine
Authors: Sandbaumhüter Friederike A. , Aerts Jordan T. , Theurillat Regula , Andrén Per E. , Thormann Wolfgang , Jansson Erik T. 
Published: November 2022

AbstractThe chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression. The metabolite hydroxynorketamine (HNK) plays an important role in the antidepressant mechanism of action. Hydroxylation at the cyclohexanone ring occurs at positions 4, 5, and 6 and produces a total of 12 stereoisomers. Among those, the four 6HNK stereoisomers have the strongest antidepressant effects. Capillary electrophoresis with highly sulfated γ‐cyclodextrin (CD) as a chiral selector in combination with mass spectrometry (MS) was used to develop a method for the enantioselective analysis of HNK stereoisomers with a special focus on the 6HNK stereoisomers. The partial filling approach was applied in order to avoid contamination of the MS with the chiral selector. Concentration of the chiral selector and the length of the separation zone were optimized. With 5% highly sulfated γ‐CD in 20 mM ammonium formate with 10% formic acid and a 75% filling the four 6HNK stereoisomers could be separated with a resolution between 0.79 and 3.17. The method was applied to analyze fractionated equine urine collected after a ketamine infusion and to screen the fractions as well as unfractionated urine for the parent drug ketamine and other metabolites, including norketamine and dehydronorketamine.
A framework for seismic response analysis of dams using numerical source‐to‐structure simulation
Authors: Zhang Meng‐Zhong , Zhang Lei , Wang Xiang‐Chao , Su Wei , Qiu Yi‐Xiang , Wang Jin‐Ting , Zhang Chu‐Han 
Published: November 2022

AbstractThe determination of spatially‐varying broadband ground motions is a prerequisite for the seismic analysis of dams. However, generating realistic ground motions at a specific dam site remains a challenge. Source‐to‐structure simulation, which considers source, propagation path, and site, is a promising way to reasonably synthesize site‐specific ground motions. This paper proposes a practical framework for the seismic analysis of dams based on a deterministic numerical source‐to‐structure simulation. The site‐specific broadband ground motions are generated by a physics‐based 3D numerical simulation using the spectral element method (SEM) in a coarse mesh, while the nonlinear dynamic response of the dam is simulated by the finite element method (FEM) in a fine mesh. The proposed framework bridges the gap between wavefield simulation and seismic analysis of dams. The seismic response analysis of Pacoima dam during the 1994 Northridge earthquake was conducted as a case study, making it the first demonstration of a complete source‐to‐structure simulation for realistic concrete dams using the purely numerical method. Results show that the calculated seismic response agrees with the observation, thus indicating the utility of the proposed framework for source‐to‐dam simulation.
Development of a Harmonized Protocol for Measurement of Foliar Wash-off Parameters: First Results
Authors: Hand Laurence H. , Hellpointner Eduard , Volz Petra , Perry Alexandra , Rieder Benjamin , Gourlay Victor , Hüben Michael , Popescu Marian 
Published: November 2022

Abstract
The foliar wash-off coefficient is a parameter used by environmental fate models to estimate the amount of chemical removed from leaf surfaces by rainfall. In the European Union it is used by FOCUS surface water models to estimate soil loadings following rainfall after leaf surfaces have been treated with plant protection products. Currently, a default value of 0.5/cm is assumed for this parameter, although there is provision to provide experimental data to replace this default. The European Food Safety Authority proposed to increase the default parameter value to 1.0/cm. This increases the need for experimental refinement studies. However, no guidance for a harmonized protocol exists to estimate this parameter. We describe the results of a ring-test conducted to start a process of developing a harmonized experimental protocol to measure the foliar wash-off parameters, conducted by several laboratories across Europe. The proposed design uses whole plants (rather than individual leaves) to retain as much realism as possible. The extent of wash-off is then determined by comparison of compound residues in two sets of plants (with and without a defined rainfall event) measured using a fully validated crop residue method. This initial ring test used tebuconazole (Folicur EW 250) sprayed at 100 g ai/ha onto tomato plants at BBCH25. Each laboratory measured the residues before and after a rainfall event of 20 mm/h for 1 h and calculated the percentage of wash-off from these data. There was good agreement across the eight participating laboratories with a mean percentage of wash-off of 66.8% and a 95% confidence interval of ±11.8%. Determination of robust wash-off parameters was therefore considered feasible using the proposed test design. Environ Toxicol Chem 2023;42:535–541. © 2022 SETAC
Abstract
Development of a harmonized protocol for measurement of foliar wash-off parameters: first results.
Comparison of Multiple Linear Regression and Biotic Ligand Models for Predicting Acute and Chronic Zinc Toxicity to Freshwater Organisms
Authors: DeForest David K. , Ryan Adam C. , Tear Lucinda M. , Brix Kevin V. 
Published: November 2022

Abstract
Multiple linear regression (MLR) models for predicting zinc (Zn) toxicity to freshwater organisms were developed based on three toxicity-modifying factors: dissolved organic carbon (DOC), hardness, and pH. Species-specific, stepwise MLR models were developed to predict acute Zn toxicity to four invertebrates and two fish, and chronic toxicity to three invertebrates, a fish, and a green alga. Stepwise regression analyses found that hardness had the most consistent influence on Zn toxicity among species, whereas DOC and pH had a variable influence. Pooled acute and chronic MLR models were also developed, and a k-fold cross-validation was used to evaluate the fit and predictive ability of the pooled MLR models. The pooled MLR models and an updated Zn biotic ligand model (BLM) performed similarly based on (1) R2, (2) the percentage of effect concentration (ECx) predictions within a factor of 2.0 of observed ECx, and (3) residuals of observed/predicted ECx versus observed ECx, DOC, hardness, and pH. Although fit of the pooled models to species-specific toxicity data differed among species, species-specific differences were consistent between the BLM and MLR models. Consistency in the performance of the two models across species indicates that additional terms, beyond DOC, hardness, and pH, included in the BLM do not help explain the differences among species. The pooled acute and chronic MLR models and BLM both performed better than the US Environmental Protection Agency's existing hardness-based model. We therefore conclude that both MLR models and the BLM provide an improvement over the existing hardness-only models and that either could be used for deriving ambient water quality criteria. Environ Toxicol Chem 2023;42:393–413. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC
NIR light‐propelled bullet‐shaped carbon hollow nanomotors with controllable shell thickness for the enhanced dye removal
Authors: Lv Jinyang , Xing Yi , Li Xiaoyu , Du Xin 
Published: November 2022

AbstractMaterials with asymmetric nanostructures have attracted tremendous research attention due to their unique structural characteristics, excellent physicochemical properties, and promising prospects. However, it is still difficult to design and fabricate bullet‐shaped nanostructure due to its structural complexity. Herein, for the first time, we successfully constructed NIR light‐propelled bullet‐shaped hollow carbon nanomotors (BHCNs) with an open mouth on the bottom of nano‐bullet for the enhanced dye removal, by employing bullet‐shaped silica nanoparticles (B‐SiO2 NPs) as a hard template. BHCNs were formed by the growth of polydopamine (PDA) layer on the heterogeneous surface of B‐SiO2 NPs, followed by the carbonization of PDA and subsequent selective etching of SiO2. The shell thickness of BHCNs was able to be facilely controlled from ≈ 14 to 30 nm by tuning the added amount of dopamine. The combination of streamlined bullet‐shaped nanostructure with good photothermal conversion efficiency of carbon materials facilitated the generation of asymmetric thermal gradient field around itself, thus driving the motion of BHCNs by self‐thermophoresis. Noteworthily, the diffusion coefficient (De) and velocity of BCHNs with shell thickness of 15 nm (BHCNs‐15) reached to 43.8 μm⋅cm−2 and 11.4 μm⋅s−1, respectively, under the illumination of 808 nm NIR laser with the power density of 1.5 W⋅cm−2. The NIR laser propulsion caused BCHNs‐15 to enhance the removal efficiency (53.4% vs. 25.4%) of methylene blue (MB) as a typical dye because the faster velocity could produce the higher micromixing role between carbon adsorbent and MB. Such a smart design of the streamlined nanomotors may provide a promising potential in environmental treatment, biomedical and biosensing applications.
Dynamic forecasting for nonstationary high‐frequency financial data with jumps based on series decomposition and reconstruction
Authors: Song Yuping , Li Zhenwei , Ma Zhiren , Sun Xiaoyu 
Published: November 2022

AbstractHigh‐frequency financial data generally possess nonlinear and nonstationary characteristics and usually contain jumping parts, which makes it difficult to establish an accurate forecasting model. In this paper, we first decompose the nonstationary high‐frequency financial time series through the variational mode decomposition (VMD), then construct the traditional autoregressive moving average (ARIMA) model on the trend and periodic items to capture the characteristics of the high‐frequency series, construct a deep learning long short‐term memory (LSTM) model on the disturbance item to fit the nonlinear trend of the data, and finally reconstruct the decomposed series by multiple linear regression. Through the Monte Carlo simulation and empirical data, it is found that under various evaluation criteria, the VMD‐LSTM model is more accurate in forecasting the nonstationary high‐frequency financial data with jumps, compared with the single ARIMA model, machine learning, and deep learning model. The VMD‐LSTM model has reduced 21.74%, 94.69%, and 48.57% on the mean absolute error (MAE) of forecasting compared with other models such as the ARIMA model, machine learning, and deep learning model. Furthermore, we construct a trading strategy for the ChiNext index based on the VMD‐LSTM model, which presents a good return and can provide investors with reasonable suggestions.
Single ectopic ureter opening into a vaginal cyst associated with multiple urogenital tract malformation: A rare case report
Authors: Zhao Meidan , Shu Changfa , Traoré Absatou , Li Fang , Zhang Aiqian , Xu Dabao 
Published: November 2022

SynopsisThis case presented a unique report of single ectopic ureter opening into a vaginal cyst associated with multiple congenital abnormalities in a prepubertal girl.
Outcomes of acute type A aortic dissection repair during pregnancy
Authors: Wang Zhigang , Sun Hongyan , Zhang Chi , Lu Lichong , Zhang Lifang , Wang Dongjin 
Published: November 2022

AbstractObjectiveTo evaluate the efficacy and safety of performing cesarean section surgery before aortic repair after acute type A aortic dissection (ATAAD) during pregnancy.MethodsA total of six patients who received ATAAD repair during their pregnancies were retrospectively identified in the hospital database from January 2002 to December 2021.ResultsThe mean gestational period at the time of aortic repair was 35.3 ± 2.7 weeks, and the aortic root diameter ranged from 40 to 60 mm. The mean time from disease onset to arrival at the operation room was 20.3 ± 10.8 h (range 10–36 h). All patients successfully received aortic repair operations following cesarean section and survived the peri‐surgery period without developing major complications. All fetuses were successfully delivered. After an average follow up of 25.8 months, all patients and their children had survived without developing major complications except for one mother who committed suicide 6 months after discharge as a result of postpartum depression.ConclusionThe present study suggested that ATAAD repair can be safely performed in the third‐trimester.