bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitization of supply chain: a case of Haryana (India) public distribution system
Authors: Tapar Archit Vinod , Jain Deepika , Patro Archana 
Published: December 2022

Learning outcomes
The learning outcomes are as follows: to decipher the role of technology in the supply chain management (SCM); to understand the importance of supply chain integration with various stakeholders in the supply chain in increasing efficiency and effectiveness; and to comprehend the challenges in the implementation of technology in SCM.

Case overview/synopsis
This case study presents Haryana’s challenges in implementing the digitization of the supply of food grains to the public. Mr Srinivas, a consultant to the Department of Food and Public Distribution, is required to suggest the future roadmap while accounting for the challenges faced in the digitization of the distribution of grains to the public in the state of Haryana. The students are expected to use the information given in the case and exhibits to discuss and critically think about the various stakeholders involved when change initiatives are implemented on an organizational level and recommend solutions based on the voices of various internal stakeholders.

Complexity academic level
Postgraduate/Masters in Business Administration/Masters in Management.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 9: Operations and Logistics.
An artificial intelligent manufacturing process for high-quality low-cost production
Authors: Hassan Noha M. , Hamdan Ameera , Shahin Farah , Abdelmaksoud Rowaida , Bitar Thurya 
Published: December 2022

PurposeTo avoid the high cost of poor quality (COPQ), there is a constant need for minimizing the formation of defects during manufacturing through defect detection and process parameters optimization. This research aims to develop, design and test a smart system that detects defects, categorizes them and uses this knowledge to enhance the quality of subsequent parts.Design/methodology/approachThe proposed system integrates data collected from the deep learning module with the machine learning module to develop and improve two regression models. One determines if set process parameters would yield a defective product while the second model optimizes them. The deep learning model utilizes final product images to categorize the part as defective or not and determines the type of defect based on image analysis. The developed framework of the system was applied to the forging process to determine its feasibility during actual manufacturing.FindingsResults reveal that implementation of such a smart process would lead to significant contributions in enhancing manufacturing processes through higher production rates of acceptable products and lower scrap rates or rework. The role of machine learning is evident due to numerous benefits which include improving the accuracy of the regression model prediction. This artificial intelligent system enhances itself by learning which process parameters could lead to a defective product and uses this knowledge to adjust the process parameters accordingly overriding any manual setting.Research limitations/implicationsThe proposed system was applied only to the forging process but could be extended to other manufacturing processes.Originality/valueThis paper studies how an artificial intelligent (AI) system can be developed and used to enhance the yield of good products.
Quality improvement of long oil alkyd (LOA) resin requirements in the formulation of Hi-gloss paints
Authors: James Joseph Myoka , Taifa Ismail W. R. 
Published: December 2022

PurposeThis research aimed at lowering the non-volatile matter (NVM) of long oil alkyd (LOA) resin to meet the resin requirements in producing Hi-gloss paints. The research also aimed to assist Hi-gloss paint manufacturers who require solid resin content below 70%.Design/methodology/approachThe research utilised both the document review and experimental methods. The experimental method, which involved the blending process, was used in lowering the NVM of LOA resin, whereby eight experiments were conducted as reputations to obtain accurate data and results. A factorial design was used in the design of the experiment (DOE), where three factors were required to be evaluated: specific gravity, viscosity and NVM and two levels were required: weight of LOA and white spirit.FindingsThe NVM of LOA resin was successfully lowered, and different shades of paint were produced for reliability testing. The quality parameters of Hi-gloss paints that used the modified LOA were all found within the company's specifications compared to those with unmodified LOA, where some parameters were either above or below the specifications. However, all samples with the NVM of LOA used below 50% were found to be poor in terms of quality during the reliability testing. So, if the company had used the modified LOA resin in the production of Hi-gloss paints, it would have potentially saved 18,925.2 kg and 9,446.4 kg, respectively, of LOA just in producing Hi-gloss black and white paints only. Moreover, the cost of 1 kg of LOA is $2.3, which is equal to Tanzanian Shillings (Tshs) 5,290. The company would have potentially saved Tshs 100.114 million Tshs and Tshs 49.97 million Tshs in producing Hi-gloss black and white paints, respectively, making a total of Tshs 150.08 million per year. This was counted as a loss during that year because they did not use LOA resin with 50% NVM in production.Research limitations/implicationsThis study focused on LOA resin used in producing Hi-gloss paints. The study also did not consider other categories of alkyd resins used in producing paints and varnishes e.g. epoxy resin and short and medium oil alkyd resins.Originality/valueThis is probably the first alkyd resin improvement study conducted using white spirit as Tanzania's main agent or material. The study utilised vegetable oils such as coconut, sunflower and tobacco seeds.
CEO general work experience and FDI-based internationalization
Authors: Xu Le 
Published: December 2022

PurposeThe purpose of this study is to study the impact of the chief executive officer (CEO) general work experience on the level of firm internationalization in the form of foreign direct investment.Design/methodology/approachThe author collects and analyzes data on publicly traded US firms in the manufacturing sector from 1993 to 2012.FindingsThe author finds that CEOs with more general work experience tend to engage in a higher degree of foreign direct investment (FDI)-based internationalization. This relationship will be weakened by CEO stock ownership and enhanced by CEO Ivy League education.Originality/valueThis study enriches the understanding of the important role top managers play in internationalization decisions. The study also contributes to the literature on managerial risk-taking by exploring the outcomes of managerial risk-taking, which have been less studied than the antecedents.
Disentangling the effects of microalgal diversity and thermal history on freshwater phototrophic biofilms facing heat stress: A thermal dose approach
Authors: Courcoul Camille , Laviale Martin , Baillard Vincent , Billoir Elise , Leflaive Joséphine , Boulêtreau Stéphanie 
Published: December 2022

Abstract

The increase in heatwave intensity and duration is challenging microalgal photosynthesis in shallow waters. In particular, the extent of photosynthesis impairment or limitation due to short extreme heat stress events occurring during a heatwave remains unknown.

In this study, we investigated the importance of microalgal diversity and thermal history in response of phototrophic biofilms to severe heat stress. We exposed isolated microalgal strains, synthetic communities previously acclimated at three temperatures, and natural phototrophic biofilms sampled at different seasons to several temperature/duration pairs (from 31 to 44°C for 30, 60, 120 or 180 min). Microalgal photosynthetic activity (FV/FM) was measured after each heat stress and was shown to be a function of thermal dose, defined as the product of time and an exponential function of temperature.

It appeared that the thermal history plays an important role in tolerance to heat stress, with synthetic communities acclimated at highest temperature being more tolerant. However, the responsiveness (i.e. the strength of the response) to heat stress was driven by the microalgal diversity of the community.

Synthesis. Our analysis showed that although photosynthetic activity was negatively impacted by heat stress, gross primary productivity was even more strongly and rapidly impacted, highlighting the fact that in situ, even moderate heat stress can significantly impair primary productivity in shallow waters.
The Impacts of Land and Real Estate Price Fluctuations on Financial Stability: Evidence from China
Authors: Wang Jinsong , Wu Wenhui , Li Yueqiao , Yang Qiyuan 
Published: December 2022

AbstractWe construct a provincial financial stability index, and use panel vector autoregression to construct a model for empirical testing. We find that local governments' reliance on land grant premiums amplifies the impact on financial stability. In addition, the relationship between the real estate market and the financial system allows real estate price fluctuations to significantly affect market participants, further impacting financial system stability. Finally, in the eastern region, land price fluctuations have a less adverse impact on financial stability, while in other regions, rising commodity real estate prices are the biggest threat to financial stability.
Does the primary treatment sequence affect post‐relapse survival in recurrent epithelial ovarian cancer? A real‐world multicentre retrospective study
Authors: Liu Xingyu , Zhao Yingjun , Jiao Xiaofei , Yu Yang , Li Ruyuan , Zeng Shaoqing , Chi Jianhua , Ma Guanchen , Huo Yabing , Li Ming , Peng Zikun , Liu Jiahao , Zhou Qi , Zou Dongling , Wang Li , Li Qingshui , Wang Jing , Yao Shuzhong , Chen Youguo , Ma Ding , Hu Ting , Gao Qinglei 
Published: December 2022

AbstractObjectiveTo explore the impact of the primary treatment sequence (primary debulking surgery, PDS, versus neoadjuvant chemotherapy and interval debulking surgery, NACT‐IDS) on post‐relapse survival (PRS) and recurrence characteristics of recurrent epithelial ovarian cancer (REOC).DesignReal‐world retrospective study.SettingTertiary hospitals in China.PopulationA total of 853 patients with REOC at International Federation of Gynaecology and Obstetrics stages IIIC–IV from September 2007 to June 2020. Overall, 377 and 476 patients received NACT‐IDS and PDS, respectively.MethodsPropensity score‐based inverse probability of treatment weighting (IPTW) was performed to balance the between‐group differences.Main Outcome MeasuresClinicopathological factors related to PRS.ResultsThe overall median PRS was 29.3 months (95% CI 27.0–31.5 months). Multivariate analysis before and after IPTW adjustment showed that NACT‐IDS and residual R1/R2 disease were independent risk factors for PRS (p < 0.05). Patients with diffuse carcinomatosis and platinum‐free interval (PFI) ≤ 12 months had a significantly worse PRS (p < 0.001). Logistic regression analysis revealed that NACT‐IDS was an independent risk factor for diffuse carcinomatosis (OR 1.36, 95% CI 1.01–1.82, p = 0.040) and PFI ≤ 12 months (OR 1.59, 95% CI 1.08–2.35, p = 0.019). In IPTW analysis, NACT‐IDS was still significantly associated with diffuse carcinomatosis (OR 1.29, 95% CI 1.05–1.58, p = 0.015) and PFI ≤ 12 months (OR 1.90, 95% CI 1.52–2.38, p < 0.001).ConclusionsThe primary treatment sequence may affect the PRS of patients with REOC by altering the recurrence pattern and PFI duration.
LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR‐101‐3p/BRD4 axis
Authors: Shao Ping , Liu Huijie , Xue Yanyan , Xiang Ting , Sun Zhanjuan 
Published: December 2022

AbstractIntroductionAcute gouty arthritis (AGA) is characterized by the accumulation of pro‐inflammatory factors. This research aimed to examine the regulation of long non‐coding RNA HOXA distal transcript antisense RNA (HOTTIP) in AGA on inflammation and its potential mechanisms.MethodsSerum levels of HOTTIP in AGA patients were examined by reverse‐transcription quantitative polymerase chain reaction. The receiver operating characteristic curve was performed in the diagnosis of AGA patients. Monosodium urate (MSU) stimulation of THP‐1‐derived macrophages was used to establish an in vitro AGA model. Enzyme‐linked immunosorbent assay was carried out to assess the levels of pro‐inflammatory cytokines. Pearson correlation was applied to examine the correlation. RNA immunoprecipitation assay and dual‐luciferase reporter assay were employed to identify the targeting relationship between miR‐101‐3p and HOTTIP or bromodomain‐containing 4 (BRD4).ResultsHOTTIP and BRD4 were statistically overexpressed in AGA patients compared with controls, while miR‐101‐3p was reduced (P < 0.05). Serum HOTTIP can significantly distinguish AGA patients from healthy controls. HOTTIP bound with miR‐101‐3p then augmented BRD4 via a competing endogenous RNA mechanism. Additionally, HOTTIP levels were elevated in a dose‐dependent manner by MSU (P < 0.05). Weakened HOTTIP significantly inhibited MSU‐induced release of pro‐inflammatory factors interleukin (IL)‐1β, IL‐8, and transforming growth factor‐α in macrophages (P < 0.05), but this inhibition was reversed by silencing miR‐101‐3p (P < 0.05).ConclusionIn short, HOTTIP contributes to inflammation via miR‐101‐3p/BRD4 axis, and serves as a new diagnostic biomarker. This study offers a renewed perspective on the diagnosis and treatment of AGA.
Epidemiology of esophageal cancer in 2020 and projections to 2030 and 2040
Authors: Liu Chun‐Quan , Ma Yun‐Lei , Qin Qi , Wang Pei‐Hao , Luo Yi , Xu Peng‐Fei , Cui Yong 
Published: December 2022

AbstractEsophageal cancer is a familiar malignancy with high incidence and mortality, and the overall prognosis is poor. The numbers of cases of and deaths from esophageal cancer have risen rapidly in recent decades. It is one of the most malignant cancers, with more than 0.6 million new cases and 0.54 million deaths worldwide in 2020. Here, we present the global epidemiology of esophageal cancer in 2020 and projections to 2030 and 2040 at different geographical levels of continents, regions and countries, and analyze them by gender, race, geographic region and human development index. We summarize the prospects for the esophageal cancer burden and risk factors in different areas, which will be useful for global esophageal cancer clinical therapy and cancer control planning.
Evaluation of a new medical retrieval and primary health care advice model in Central Australia: Results of pre‐ and post‐implementation surveys
Authors: Green Danielle , Russell Deborah Jane , Zhao Yuejen , Mathew Supriya , Fitts Michelle Susannah , Johnson Richard , Reeve David Mark , Honan Bridget , Niclasen Petra , Liddle Zania , Maguire Graeme , Remond Marc , Wakerman John 
Published: December 2022

AbstractIntroductionIn February 2018 the Remote Medical Practitioner (RMP)‐led telehealth model for providing both primary care advice and aeromedical retrievals in Central Australia was replaced by the Medical Retrieval and Consultation Centre (MRaCC) and Remote Outreach Consultation Centre (ROCC). In this new model, specialists with advanced critical care skills provide telehealth consultations for emergencies 24/7 and afterhours primary care advice (MRaCC) while RMPs (general practitioners) provide primary care telehealth advice in business hours via the separate ROCC.ObjectiveTo evaluate changes in clinicians’ perceptions of efficiency and timeliness of the new (MRaCC) and (ROCC) model in Central Australia.DesignThere were 103 and 72 respondents, respectively, to pre‐ and post‐implementation surveys of remote clinicians and specialist staff.FindingsBoth emergency and primary care aspects of telehealth support were perceived as being significantly more timely and efficient under the newly introduced MRaCC/ROCC model. Importantly, health professionals in remote community were more likely to feel that their access to clinical support during emergencies was consistent and immediately available.DiscussionRespondents consistently perceived the new MRaCC/ROCC model more favourably than the previous RMP‐led model, suggesting that there are benefits to having separate referral streams for telehealth advice for primary health care and emergencies, and staffing the emergency stream with specialists with advanced critical care skills.ConclusionGiven the paucity of literature about optimal models for providing pre‐hospital medical care to remote residents, the findings have substantial local, national and international relevance and implications, particularly in similar geographically large countries, with low population density.
PROspective Meta‐analysis Of Trials of Initial Oxygen in preterm Newborns (PROMOTION): Protocol for a systematic review and prospective meta‐analysis with individual participant data on initial oxygen concentration for resuscitation of preterm infants
Authors: Sotiropoulos James X. , Schmölzer Georg M. , Oei Ju Lee , Libesman Sol , Hunter Kylie E. , Williams Jonathan G. , Webster Angela C. , Tarnow‐Mordi William O. , Vento Maximo , Asztalos Elizabeth , Shah Prakesh S. , Katheria Anup , Seidler Anna Lene 
Published: December 2022

AbstractBackgroundClinicians favour low oxygen concentrations when resuscitating preterm infants immediately after birth despite inconclusive evidence to support this practice. Prospective meta‐analysis (PMA) is a novel approach where studies are identified as eligible for inclusion in the meta‐analysis before their results are known.AimsTo explore whether high (60%) or low (30%) oxygen is associated with greater efficacy and safety for the initial resuscitation (immediately after birth) of preterm infants born at <29 weeks' gestation.MethodsWe will conduct a prospective meta‐analysis (PMA) with individual participant data (IPD). We will perform a systematic search to identify ongoing RCTs including infants <29 weeks' gestation randomised to high (60%) or low (30%) oxygen for initial resuscitation after birth. IPD will be sought for all infants randomised for the purpose of meta‐analysis. We will employ a one‐stage random‐effects approach to IPD meta‐analysis. Potential heterogeneity and the differential effect of high or low oxygen will be explored through subgroup and interaction analyses. The primary outcome of this study is all‐cause mortality prior to hospital discharge. There will be a follow‐up analysis of neurodevelopmental outcomes once available.Results/ConclusionThe results of neonatal outcomes at hospital discharge are expected by 2025, and neurodevelopmental outcomes by 2027.
Religious pluralism and the ethics of healthcare
Authors: Audi Robert , Smith William R. 
Published: December 2022

AbstractDemocratic societies that separate church and state face major challenges in accommodating religious convictions. This applies especially to determining healthcare policies. Building on our prior work on the demands and limits of religious accommodation in democratic societies, we propose a set of ethical standards that can guide societies in meeting this challenge. In applying and defending these standards, we explore three topics: vaccine resistance, abortion, and concerns about rights to healthcare. We clarify these and other issues of religious accommodation and propose ethical standards for approaching these and other problems.
Metabolomic profile in patients with primary warm autoimmune haemolytic anaemia
Authors: Rabelo Iara B. , Chiba Akemi K. , Moritz Elyse , D'Amora Paulo , Silva Ismael Dale C. G. , Rodrigues Celso A. , Barros Melca M. O. , Bordin José O. 
Published: December 2022

SummaryAutoimmune haemolytic anaemia (AIHA) is a rare clinical condition with immunoglobulin fixation on the surface of erythrocytes, with or without complement activation. The pathophysiology of AIHA is complex and multifactorial, presenting functional abnormalities of T and B lymphocytes that generate an imbalance between lymphocyte activation, immunotolerance and cytokine production that culminates in autoimmune haemolysis. In AIHA, further laboratory data are needed to predict relapse and refractoriness of therapy, and thus, prevent adverse side‐effects and treatment‐induced toxicity. The metabolomic profile of AIHA has not yet been described. Our group developed a cross‐sectional study with follow‐up to assess the metabolomic profile in these patients, as well as to compare the metabolites found depending on the activity and intensity of haemolysis. We analysed the plasma of 26 patients with primary warm AIHA compared to 150 healthy individuals by mass spectrometry. Of the 95 metabolites found in the patients with AIHA, four acylcarnitines, two phosphatidylcholines (PC), asymmetric dimethylarginine (ADMA) and three sphingomyelins were significantly increased. There was an increase in PC, spermine and spermidine in the AIHA group with haemolytic activity. The PC ae 34:3/PC ae 40:2 ratio, seen only in the 12‐month relapse group, was a predictor of relapse with 81% specificity and 100% sensitivity. Increased sphingomyelin, ADMA, PC and polyamines in patients with warm AIHA can interfere in autoantigen and autoimmune recognition mechanisms in a number of ways (deficient action of regulatory T lymphocytes on erythrocyte recognition as self, negative regulation of macrophage nuclear factor kappa beta activity, perpetuation of effector T lymphocyte and antibody production against erythrocyte antigens). The presence of PC ae 34:3/PC ae 40:2 ratio as a relapse predictor can help in identifying cases that require more frequent follow‐up or early second‐line therapies.
Cover Image
Authors: Zhu Ning , Liu Jiayu , Ma Ting , Zhang Yu , Lin Ye 
Published: December 2022

AbstractThe cover image is based on the Original Article Fully digital versus conventional workflow for horizontal ridge augmentation with intraoral block bone: A randomized controlled clinical trial by Ning Zhu DMD et al., https://doi.org/10.1111/cid.13129.
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Adiponectin receptors activation performs dual effects on regulating myogenesis and adipogenesis of young and aged muscle satellite cells
Authors: Liu Shibo , Liu Hanghang , Liu Yao , Zhang Ju , Liu Zhikai , Zheng Zizhuo , Luo En 
Published: December 2022

AbstractObjectivesSkeletal muscle mass and function deteriorate with ageing. Adiponectin receptors (APNrs), mainly activated by adiponectin, participate in various physiological activities and have varying signalling pathways at different ages. This study aimed to explore whether discrepant performance exists in APNr activation regulating young and aged muscle satellite cells (MUSCs) and whether age‐related muscle dysfunction could be alleviated upon APNr activation.MethodsThe gastrocnemius muscle phenotype was observed in male mice aged 2 and 18 months. An APNr agonist (AdipoRon) was usedin vitroandin vivoto investigate the changes in cell biological behaviours and whether muscle dysfunction could be retarded after APNr activation.ResultsAged mice exhibited decreased muscle mass and increased fat infiltration. APNr activation inhibited C2C12 cells and young MUSCs (YMUSCs) proliferation but showed no obvious effect on aged MUSCs (AMUSCs). Moreover, APNr activation inhibited the migration of both YMUSCs and AMUSCs. Interestingly, APNr activation hampered the myogenic differentiation but advanced the adipogenic differentiation of YMUSCs, yet exact opposite results were presented in AMUSCs. It was demonstrated that Wnt and PI3K signalling pathways may mediate the phenotypic differences. Furthermore,in vivoexperiments verified that APNr activation ameliorated age‐related muscle atrophy and excessive fat infiltration.ConclusionsAPNr activation exerted dual effects on the regulation of myogenesis and adipogenesis of YMUSCs and AMUSCs and rescued age‐related skeletal muscle dysfunction.