bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI MENGHADAPI PERGESERAN PEREKONOMIAN PASCA BENCANA GEMPA LOMBOK DI KABUPATEN LOMBOK UTARA
Authors: Astri Luh Putu Vera , Hartati Sri , Taufik Mohamad Zaki 
Published: July 2022

Pembangunan tidak hanya pertumbuhan, transformasi struktur atau tatanan kelembagaan ekonomi dan sosial tapi juga tentang faktor ancaman serta resiko bencana untuk mampu diantisipasi. Gempa Lombok berdampak meningkatkan jumlah kemiskinan, dan pengangguran sehingga menghasilkan perekonomian yang tidak normal. Tahun 2018 laju pertumbuhan ekonomi Kabupaten Lombok Utara mengalami kontraksi sebesar -0,86%. Rekonstruksi & rehabilitasi yang efektif dan efisien sebagai upaya recovery perekonomian memerlukan gambaran & strategi menghadapi pergeseran kondisi ekonomi wilayah pasca kejadian bencana gempa bumi. Penelitian ini terkait dengan bagaimana gambaran pergeseran perekonomian dan strategi menghadapinya pasca kejadian bencana gempa bumi di Kabupaten Lombok Utara dengan menggunakan alat analisa pergeseran kinerja sektor dari sebelum dan sesudah bencana Gempa Lombok Tahun 2018 dan analisa penentuan strategi bersaing.Beberapa kelompok sector mengalami pergeseran yang pada tahun 2016 s/d 2017 sebelum kejadian bencana gempa bumi Lombok berada pada kuadran winners atau mixed winners turun ke kuadran mixed loser pada pasca bencana.Dari alternatif strategi yang sesuai kondisi pada pasca Gempa Lombok Tahun 2018, tipe strategi Joint Venture mendapatkan skor tertinggi diikuti strategi retrenchmentdan terakhir strategi Pengembangan Produk.
POTRET MASYARAKAT MISKIN PENYANDANG DISABILITAS DI PONOROGO : PENYEBAB DAN SOLUSI KEBIJAKAN PEMERINTAH
Authors: Pradana Intan , Widiyahseno B 
Published: July 2022

Abstrak
Penelitian ini diawali dengan fenomena yang terjadi di masyarakat penyandang disabilitas. Akibatnya terjadinya fungsi organ yang tidak sempurna. Keterbatasan ini tidak memberikan kebebasan bagi penyandang disabilitas untuk melakukan aktivitas sehari-hari. Oleh karena itu, penyandang disabilitas perlu mendapatkan perhatian khusus dalam mengembangkan kemandiriannya agar dapat menjalankan fungsi sosialnya. Penelitian ini bertujuan untuk memperjelas peran pemerintah daerah dalam mengentaskan masalah kemiskinan kelompok penyandang disabilitas. Pendekatan deskriptif dengan pendekatan kualitatif digunakan dalam penelitian ini. Penyelidikan berasal dari uraian narasumber yang dilakukan melalui wawancara, bukan angka. Pengumpulan data untuk penelitian ini melalui observasi, wawancara, dan studi pustaka. Analisis data untuk penelitian ini melibatkan pengumpulan semua data dan reduksi data untuk menarik kesimpulan sebagai hasil penelitian. Hasil penelitian menunjukkan bahwa pemerintah melakukan upaya pemberdayaan penyandang disabilitas yang didukung dengan sosialisasi dan pelatihan-pelatihan khususnya bagi penyandang disabilitas.
Kata Kunci : Kemiskinan, Penyandang Disabilitas, Kebijakan Pemerintah
The Chemistry of HNO: Mechanisms and Reaction Kinetics
Authors: Michalski Radosław , Smulik-Izydorczyk Renata , Pięta Jakub , Rola Monika , Artelska Angelika , Pierzchała Karolina , Zielonka Jacek , Kalyanaraman Balaraman , Sikora Adam Bartłomiej 
Published: July 2022

Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions.
Increased Interferon-Induced Protein With Tetracopeptides (IFITs) Reduces Mycobacterial Growth
Authors: Madhvi Abhilasha , Mishra Hridesh , Chegou Novel N. , Baker Bienyameen 
Published: July 2022

ObjectivesThe host immune response towards Mycobacterium tuberculosis (M. tb) is known to vary with the virulence of mycobacterial species. While the majority of M. tb-exposed individuals develop latent TB infection (LTBI), a small proportion develops active TB disease. The milieu of understudied immune factors is believed to play an important role against host immune response towards mycobacteria. Here, we investigate the role of antiviral factors of the interferon-induced proteins with tetracopeptides (IFITs) family, which, in our previous research, have shown to be upregulated in response to pathogenic M. tb, but as yet have no established role in host response to bacterial infections. MethodsWe performed vector-driven overexpression and siRNA-mediated downregulation of IFITs in THP-1 cells infected with different mycobacterial species. Also, we investigated the mRNA levels of IFITs in the LTBI and active-TB cases.ResultsOverexpression of IFITs reduces CFUs by ~32% (30%–43%) [Median (IQR)] across three different mycobacterial strains, while knock-down increases CFUs by ~57% (41%–78%). Compared to IFN-γ, treatment of infected THP-1 cells with IFN-β significantly increases the expression of IFITs, while the overexpression of IFITs had higher mRNA expression of IFN-β than IFN-γ. Cytokines like IDO-1, IL-6, IL-23, and IFN- γ are observed to play key roles in mycobacterial survival upon IFITs intervention. mRNA expression levels of IFITs were higher in LTBI cases as compared to active TB.ConclusionHigher expression levels of IFITs reduce in vitro survival of different drug-susceptible and drug-resistant mycobacteria and correlates with latent TB infection in infected individuals, hence emerging as an immuno-therapeutic target against M. tb.
Effects of BNP and Sacubitrilat/Valsartan on Atrial Functional Reserve and Arrhythmogenesis in Human Myocardium
Authors: Primessnig Uwe , Deißler Peter M. , Wakula Paulina , Tran Khai Liem , Hohendanner Felix , von Lewinski Dirk , Blaschke Florian , Knosalla Christoph , Falk Volkmar , Pieske Burkert , Grubitzsch Herko , Heinzel Frank R. 
Published: July 2022

BackgroundAlthough the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan started a new era in heart failure (HF) treatment, less is known about the tissue-level effects of the drug on the atrial myocardial functional reserve and arrhythmogenesis.Methods and ResultsRight atrial (RA) biopsies were retrieved from patients (n = 42) undergoing open-heart surgery, and functional experiments were conducted in muscle strips (n = 101). B-type natriuretic peptide (BNP) did not modulate systolic developed force in human myocardium during β-adrenergic stimulation, but it significantly reduced diastolic tension (p &lt; 0.01) and the probability of arrhythmias (p &lt; 0.01). In addition, patient's plasma NTproBNP positively correlated with isoproterenol-induced contractile reserve in atrial tissue in vitro (r = 0.65; p &lt; 0.01). Sacubitrilat+valsartan (Sac/Val) did not show positive inotropic effects on atrial trabeculae function but reduced arrhythmogeneity. Atrial and ventricular biopsies from patients with end-stage HF (n = 10) confirmed that neprilysin (NEP) is equally expressed in human atrial and ventricular myocardium. RA NEP expression correlates positively with RA ejection fraction (EF) (r = 0.806; p &lt; 0.05) and left ventricle (LV) NEP correlates inversely with left atrial (LA) volume (r = −0.691; p &lt; 0.05).ConclusionBNP ameliorates diastolic tension during adrenergic stress in human atrial myocardium and may have positive long-term effects on the inotropic reserve. BNP and Sac/Val reduce atrial arrhythmogeneity during adrenergic stress in vitro. Myocardial NEP expression is downregulated with declining myocardial function, suggesting a compensatory mechanism in HF.
Risk Factors and Outcomes of Acute Myocardial Infarction in a Cohort of Antiphospholipid Syndrome
Authors: Gan Yuzhou , Zhao Yawei , Li Gongming , Ye Hua , Zhou Yunshan , Hou Chang , Wang Lan , Guo Jianping , Li Chun 
Published: July 2022

BackgroundAntiphospholipid syndrome (APS) is a disorder associated with thromboembolic diseases, including acute myocardial infarction (AMI). Given that AMI is a relatively common condition with poor prognostic features, identification of risk factors for AMI in APS is important.MethodsA retrospective cohort study was performed consisting of 332 patients with APS, and 239 patients with thrombotic APS were finally included. Patients were followed up in the outpatient department for 5 years. Clinical data and laboratory parameters were analyzed to identify the risk factors for AMI in APS. The primary and secondary clinical outcomes were all-cause mortality and recurrence of thrombosis, respectively.ResultsAMI was observed in 12.1% (29/239) of patients with APS. Compared to patients without AMI, patients with AMI had multiple organ thrombosis (55.1 vs. 34.3%, p = 0.029), recurrent thrombosis (58.6 vs. 34.3%, p = 0.011), a higher incidence of atherosclerosis (62.1 vs. 23.8%, p &lt; 0.001), higher neutrophil count (×109/L) [4.68 (3.25, 8.17) vs. 3.71 (2.64, 5.80), p = 0.036], longer QT interval (ms) [438 ms (423, 454) vs. 425 ms (410, 446), p = 0.016], and fewer venous thrombosis events (27.6 vs. 63.3%, p &lt; 0.001). Multivariate logistic regression analysis (adjusted for age and gender) identified several factors that were positively associated with AMI, including multiple organ thrombosis [odds ratio (OR) 8.862, 95% confidence interval (CI): 1.817–43.212, p = 0.007), atherosclerosis (OR 5.397, 95%CI: 1.943–14.994, p = 0.001), and elevated neutrophil count (&gt;6.3 ×109/L) (OR 3.271, 95%CI: 1.268–8.440, p = 0.014). The venous thrombosis was negatively associated with AMI (OR 0.106, 95%CI: 0.036–0.314, p &lt; 0.001). Kaplan–Meier analysis revealed that the recurrence rates of arterial thrombosis differed significantly between patients with AMI and those without AMI [hazard ratio (HR) = 3.307, p = 0.038].ConclusionAtherosclerosis, multiple organ thrombosis, an increased number of neutrophils are variables positively associated with AMI in APS, and venous thrombosis had a negative association with AMI. AMI only predicts the subsequent recurrence of arterial thrombosis. These findings suggest that distinct pathophysiological mechanisms may exist and contribute to the development of venous or arterial thrombotic APS.
The Energy Storage System Integration Into Photovoltaic Systems: A Case Study of Energy Management at UTFPR
Authors: Mariano Juliana D’Angela , Urbanetz Jr Jair 
Published: July 2022

Energy storage system integration can reduce electricity costs and provide desirable flexibility and reliability for photovoltaic (PV) systems, decreasing renewable energy fluctuations and technical constraints. In this sense, this study aimed to propose energy management strategies through this integration, aiming to improve the demand profile of a university commercial consumer for compensation during peak hours. To achieve the objectives of this research, a pilot project was installed which included a 10 kWp grid-tie PV system (GTPVS), bidirectional inverters, and battery bank, as part of a research and development (R&amp;D) project implemented in the Federal University of Technology–Paraná (UTFPR) Curitiba campus at Neoville headquarters. The methodology consisted of the analysis of variables that interfere with the operation of this system, such as a detailed university profile of demand and consumption, local energy pricing, PV generation profile as well as the interaction between PV generator and the energy storage system, and the variation in power fluctuations throughout the year. Additionally, a technical feasibility study was carried out aimed to determine this consumer’s optimal size through the Homer Grid software. The detailed demand profile allowed us to know in depth the peak values were above 80 kW, for university working days. Furthermore, the daily analysis of the PV generation profile confirmed that although the PV source is quite variable, the scheduled dispatch operation is not interfered by the variability and intermittency of the solar source, as the system was designed and programmed to operate in parallel with the electrical network. Regarding the energy consumed at the university, very significant values were obtained, in which the month of July presented the highest consumption for the base year 2019, with a total monthly value of 48,670 kWh. The established operating strategy for the battery bank with a 10% discharge depth resulted in a life cycle of 2,500 cycles which can extend its useful life by approximately 9.5 years. The results obtained by the simulation show different levels of energy contribution with percentages of 60.0, 33.6, and 2.7%, respectively.
Influence of Inlet Groove on Flow Characteristics in Stall Condition of Full-Tubular Pump
Authors: Shi Lijian , Jiang Yuhang , Cai Yiping , Chen Beishuai , Tang Fangping , Xu Tian , Zhu Jun , Chai Yao 
Published: July 2022

The full-tubular pump is a new type of pump with a narrow range of stable operation. In order to improve the internal flow characteristics of the full-tubular pump under small flow conditions and improve the safe and stable operating range of the pump, this paper conducts numerical simulation of the full-tubular pump model based on the Reynolds time-averaged N-S equation and the SST k-ω turbulence model. The improvement mechanism of the parameters of the inlet grooves on the stall area of the full-tubular pump is studied, and the reliability of the numerical simulation of the full-tubular pump is verified by model tests. The research results show that the inlet groove can improve the head and efficiency of the full-tubular pump in the small flow area, and the head at the deep stall condition is increased by nearly 1.61 m. The inlet groove increases the pressure difference of the impeller, which increases the head and improves the hump. At the same time, the increase in the pressure difference of the impeller increases the backflow flow in the gap between the stator and the rotor. The groove can reduce the vortex strength and backflow range at the inlet pipe wall near the stall operating, and also improve the flow field at the impeller inlet. In terms of pressure pulsation, the groove can effectively suppress the low-frequency pressure pulsation at the inlet of the impeller of the full-tubular pump under stall conditions, and effectively reduce the amplitude of the main frequency pressure pulsation and improve the internal flow. The research in this paper can provide a reference for improving the flow characteristics in the stall condition of the full-tubular pump.
Combining Single-Cell and Transcriptomic Data Revealed the Prognostic Significance of Glycolysis in Pancreatic Cancer
Authors: Chen Liang , Lin Yunhua , Wei Wei , Wang Yue , Li Fangyue , Du Wang , Yang Zhonghua , Hu Yiming , Ying Xiaomei , Tang Qikai , Xie Jiaheng , Yu Hongzhu 
Published: July 2022

Background: Pancreatic cancer (PC), the most common fatal solid malignancy, has a very dismal prognosis. Clinical computerized tomography (CT) and pathological TNM staging are no longer sufficient for determining a patient’s prognosis. Although numerous studies have suggested that glycolysis is important in the onset and progression of cancer, there are few publications on its impact on PC.Methods: To begin, the single-sample gene set enrichment analysis (ssGSEA) approach was used to quantify the glycolysis pathway enrichment fraction in PC patients and establish its prognostic significance. The genes most related to the glycolytic pathway were then identified using weighted gene co-expression network analysis (WGCNA). The glycolysis-associated prognostic signature in PC patients was then constructed using univariate Cox regression and lasso regression methods, which were validated in numerous external validation cohorts. Furthermore, we investigated the activation of the glycolysis pathway in PC cell subtypes at the single-cell level, performed a quasi-time series analysis on the activated cell subtypes and then detected gene changes in the signature during cell development. Finally, we constructed a decision tree and a nomogram that could divide the patients into different risk subtypes, according to the signature score and their different clinical characteristics and assessed the prognosis of PC patients.Results: Glycolysis plays a risky role in PC patients. Our glycolysis-related signature could effectively discriminate the high-risk and low-risk patients in both the trained cohort and the independent externally validated cohort. The survival analysis and multivariate Cox analysis indicated this gene signature to be an independent prognostic factor in PC. The prognostic ROC curve analysis suggested a high accuracy of this gene signature in predicting the patient prognosis in PC. The single-cell analysis suggested that the glycolytic pathway may be more activated in epithelial cells and that the genes in the signature were also mainly expressed in epithelial cells. The decision tree analysis could effectively identify patients in different risk subgroups, and the nomograms clearly show the prognostic assessment of PC patients.Conclusion: Our study developed a glycolysis-related signature, which contributes to the risk subtype assessment of patients with PC and to the individualized management of patients in the clinical setting.
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome
Authors: Zapater Andrea , Solelhac Geoffroy , Sánchez-de-la-Torre Alicia , Gracia-Lavedan Esther , Benitez Ivan David , Torres Gerard , De Batlle Jordi , Haba-Rubio José , Berger Mathieu , Abad Jorge , Duran-Cantolla Joaquín , Urrutia Amaia , Mediano Olga , Masdeu María José , Ordax-Carbajo Estrella , Masa Juan Fernando , De la Peña Mónica , Mayos Mercé , Coloma Ramon , Montserrat Josep María , Chiner Eusebi , Mínguez Olga , Pascual Lydia , Cortijo Anunciación , Martínez Dolores , Dalmases Mireia , Lee Chi-Hang , McEvoy R. Doug , Barbé Ferran , Heinzer Raphael , Sánchez-de-la-Torre Manuel ,   Spanish Sleep Network
Published: July 2022

IntroductionObstructive sleep apnea (OSA) severity is based on the apnea-hypopnea index (AHI). The AHI is a simplistic measure that is inadequate for capturing disease severity and its consequences in cardiovascular diseases (CVDs). Deleterious effects of OSA have been suggested to influence the prognosis of specific endotypes of patients with acute coronary syndrome (ACS). We aim to identify respiratory polygraphy (RP) patterns that contribute to identifying the risk of recurrent cardiovascular events in patients with ACS.MethodsPost hoc analysis of the ISAACC study, including 723 patients admitted for a first ACS (NCT01335087) in which RP was performed. To identify specific RP patterns, a principal component analysis (PCA) was performed using six RP parameters: AHI, oxygen desaturation index, mean and minimum oxygen saturation (SaO2), average duration of events and percentage of time with SaO2 &lt; 90%. An independent HypnoLaus population-based cohort was used to validate the RP components.ResultsFrom the ISAACC study, PCA showed that two RP components accounted for 70% of the variance in the RP data. These components were validated in the HypnoLaus cohort, with two similar RP components that explained 71.3% of the variance in the RP data. The first component (component 1) was mainly characterized by low mean SaO2 and obstructive respiratory events with severe desaturation, and the second component (component 2) was characterized by high mean SaO2 and long-duration obstructive respiratory events without severe desaturation. In the ISAACC cohort, component 2 was associated with an increased risk of recurrent cardiovascular events in the third tertile with an adjusted hazard ratio (95% CI) of 2.44 (1.07 to 5.56; p-value = 0.03) compared to first tertile. For component 1, no significant association was found for the risk of recurrent cardiovascular events.ConclusionA RP component, mainly characterized by intermittent hypoxemia, is associated with a high risk of recurrent cardiovascular events in patients without previous CVD who have suffered a first ACS.
Two Years of Evolutionary Dynamics of SARS-CoV-2 in Mexico, With Emphasis on the Variants of Concern
Authors: Flores-Alanis Alejandro , Delgado Gabriela , Espinosa-Camacho Luis F. , Rodríguez-Gómez Flor , Cruz-Rangel Armando , Sandner-Miranda Luisa , Cravioto Alejandro , Morales-Espinosa Rosario 
Published: July 2022

BackgroundThe advance of the COVID-19 pandemic and spread of SARS-CoV-2 around the world has generated the emergence of new genomic variants. Those variants with possible clinical and therapeutic implications have been classified as variants of concern (VOCs) and variants of interest (VOIs).ObjectiveThis study aims to describe the COVID-19 pandemic and build the evolutionary and demographic dynamics of SARS-CoV-2 populations in Mexico, with emphasis on VOCs.Methods30,645 complete genomes of SARS-CoV-2 from Mexico were obtained from GISAID databases up to January 25, 2022. A lineage assignment and phylogenetic analysis was completed, and demographic history for Alpha, Gamma, Delta and Omicron VOCs, and the Mexican variant (B.1.1.519) was performed.Results148 variants were detected among the 30,645 genomes analyzed with the Delta variant being the most prevalent in the country, representing 49.7% of all genomes.ConclusionThe COVID-19 pandemic in Mexico was caused by several introductions of SARS-CoV-2, mainly from the United States of America and Europe, followed by local transmission. Regional molecular epidemiological surveillance must implement to detect emergence, introductions and spread of new variants with biologically important mutations.
The Natural History of Spinocerebellar Ataxia Type 3 in Mainland China: A 2-Year Cohort Study
Authors: Peng Yun , Peng Linliu , Chen Zhao , Peng Huirong , Wang Puzhi , Zhang Youming , Li Yangping , Wang Chunrong , Shi Yuting , Hou Xuan , Long Zhe , Yuan Hongyu , Wan Na , Wan Linlin , Xu Keqin , Lei Lijing , Wang Shang , He Lang , Xie Yue , Gong Yiqing , Deng Qi , Zou Guangdong , Tang Zhichao , Shen Lu , Xia Kun , Qiu Rong , Klockgether Thomas , Tang Beisha , Jiang Hong 
Published: July 2022

ObjectiveThe natural history of spinocerebellar ataxia type 3 (SCA3) has been reported in several populations and shows heterogeneity in progression rate and affecting factors. However, it remains unexplored in the population of Mainland China. This study aimed to identify the disease progression rate and its potential affecting factors in patients with SCA3 in Mainland China.Participants and MethodsWe enrolled patients with genetically confirmed SCA3 in Mainland China. Patients were seen at three visits, i.e., baseline, 1 year, and 2 years. The primary outcome was the Scale for the Assessment and Rating of Ataxia (SARA), and the secondary outcomes were the Inventory of Non-Ataxia Signs (INAS) as well as the SCA Functional Index (SCAFI).ResultsBetween 1 October 2015, and 30 September 2016, we enrolled 263 patients with SCA3. We analyzed 247 patients with at least one follow-up visit. The annual progression rate of SARA was 1.49 points per year (SE 0.08, 95% confidence interval [CI] 1.33–1.65, p &lt; 0.0001). The annual progression rates of INAS and SCAFI were 0.56 points per year (SE 0.05, 95% CI 0.47–0.66, p &lt; 0.001) and −0.30 points per year (SE 0.01, 95% CI −0.33∼-0.28, p &lt; 0.001), respectively. Faster progression in SARA was associated with longer length of the expanded allele of ATXN3 (p &lt; 0.0001); faster progression in INAS was associated with lower INAS at baseline (p &lt; 0.0001); faster decline in SCAFI was associated with shorter length of the normal allele of ATXN3 (p = 0.036) and higher SCAFI at baseline (p &lt; 0.0001).ConclusionOur results provide quantitative data on the disease progression of patients with SCA3 in Mainland China and its corresponding affecting factors, which could facilitate the sample size calculation and patient stratification in future clinical trials.Trial RegistrationThis study was registered with Chictr.org on 15 September 2015, number ChiCTR-OOC-15007124.