bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the coronavirus disease course in young children
Authors: Kosmynina N. S. , Avramenko I. Yu. 
Published: January 2022

The aim. To analyze the features of the coronavirus disease course in young children.
Materials and methods. We analyzed case histories of 60 children aged 0 to 3 years who were hospitalized to the Lviv Regional Children’s Clinical Hospital “OHMATDYT” in the period from April to December 2020 with a diagnosis of coronavirus disease. Out of the 60 children 36 (60 %) were boys and 24 (40 %) were girls. Laboratory studies on the presence of SARS-CoV-2 virus RNA were performed in samples of nasal and pharyngeal swabs by PCR at the State Institution “Lviv Regional Laboratory Center of the Ministry of Health of Ukraine”. Blood and urinary laboratory tests were performed on the basis of the Laboratories in Lviv Regional Children’s Clinical Hospital “OHMATDYT”. The result were statistically processed using Excel software from Microsoft Office 2019 packages. Quantitative characteristics were given as M ± m (arithmetic mean ± standard deviation of the arithmetic mean).
Results. It was found that 40% of children under 1 year old and only 15% from 1 to 3 years old were hospitalized on the first day of the disease. Parents of sick children in 51 (85 %) cases confirmed the presence of contact with infected family members. The analysis of the disease clinical manifestations showed that during the disease course, most children with coronavirus disease had the following clinical manifestations: fever, runny nose, cough, abdominal pain, diarrhea, and general weakness. Lymphopenia, which is the most common laboratory finding in adults with COVID-19, was found only in 28 % of children hospitalized to the Regional Children’s Clinical Hospital “OHMATDYT”. The presence of complications in the form of pneumonia was observed in 5 children, which amounted to 8.3 %. The average duration of inpatient treatment for children under 1 year of age was 7 days, and it was 6 days for children between 1 and 3 years of age.
Conclusions. It was found that 85% of child inpatients were in contact with family members in whom the presence of SARS-CoV-2 infection was confirmed. The main manifestations of coronavirus disease were fever ˃38 °C and general weakness in more than 55% of children aged 0 to 3 years. The level of leukocytes within the age norm was observed in 46.6% of children, leukopenia– in 35.0%, and lymphopenia– in 28.3%. The course of the disease among young children was mild, and only 8.3% of children had the moderately severe course, complicated by pneumonia.
LncRNA SRA gene polymorphisms and risk of gynecological pathology development among Ukrainian women with proliferative type of benign breast disease without atypia
Authors: Lukavenko I. M. , Kolnoguz A. V. , Harbuzova V. Yu. , Ataman O. V. 
Published: January 2022

Benign breast disease is a group of all noncancerous mammary lesions with a risk of breast cancer (BC) development. BC is the most common cancer in the world; therefore, it is necessary to find new biomarkers and targets for early diagnosis, treatment, prediction of prognosis and survival. Long non-coding RNA SRA could play this role, thus further studies of its impact on the precancerous lesion pathogenesis are needed.
The aim. To analyze the association between SRA1 rs801460 and rs10463297 SNPs and the occurrence of gynecological pathology among Ukrainian women with the proliferative type of benign breast disease without atypia.
Materials and methods. This study included 115 patients with proliferative type of benign breast disease without atypia: 55 – with gynecological pathology and 60 – without it. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for polymorphism genotyping.
Hematoxylin and eosin, toluidine blue and van Gieson’s picrofuchsin methods were applied for staining of sections. Statistical analysis was carried out using Statistical Package for the Social Sciences software (SPSS, version 25.0, Chicago, IL, USA).
Results. Significant differences were found in the rs10463297 frequency of alleles (P = 0.032), but not in the rs801460 (P > 0.05), in groups with and without gynecological pathology, while the distribution of both single nucleotide polymorphism (SNPs) genotypes was similar between these groups (P > 0.05). Statistically significant association was detected between SRA1 rs10463297 polymorphism and gynecological pathology occurrence in both dominant (Pa = 0.023; ORa = 2.638, 95 % CI = 1.145–6.076) and additive (Pa = 0.034; ORa = 2.489, 95 % CI = 1.069–5.794) models of inheritance.
No association was found between SRA1 rs801460 SNP and gynecological pathology development among Ukrainian women with proliferative type of benign breast disease without atypia (P > 0.05).
Conclusions. It was revealed that SRA1 rs10463297 TT carriers had 2.6 times higher risk of gynecological pathology development than C allele carriers and 2.48 times than TC carriers.
Tumor budding as a prognostic criterion of colorectal cancer
Authors: Yakovtsova I. I. , Cheverda V. M. , Dolhaia O. V. , Yakymenko A. S. , Ivakhno I. V. 
Published: January 2022

Colorectal cancer (CRC) is the second leading cause of mortality among cancers after malignant tumors of respiratory system. One of the most significant prognostic features of CRC is tumor budding (TB), which isn’t widely implemented in clinical practice.
The aim of this research: to find the prognostic criteria of recurrence and lethal outcome of CRR IIA and IIIB stages (рТ3N0-2M0), the ratio of tumors with certain differentiation in groups of research was taken equal.
Material and methods. The group I was formed from primary CRC without recurrences. The main relapse-free survival time was 5 years (62.5 ± 16.5 months). The ІІ group – primary CRC with recurrences; ІІА – with recurrences during 5 years from the moment when the tumor was removed, without fatal outcome; ІІВ – with recurrences and lethal outcome from genera­lization of tumor process during 5 years from the moment when the tumor was removed. The microslides of CRC were made by using the standard methods.
Results. TB was identified in 46.66 % (28/60) of CRC рТ3N0-2M0. The direct relationship between tumor grade and presence of TB was found (Р < 0.05), but TB didn’t define differentiation of the CRC. There was a statistically significant relationship between TB and metastatic spreading of CRC to regional lymph nodes (Р < 0.001). Metastasis was associated with 3 stage of TB, absence of metastasis was typical for CRC without TB.
The tendency was found in a larger number of cases of the CRC with TB 3 stage among recurring CRC compared with CRC without recurrence, mainly due to the ІІВ group of the research. Inverse correlation between TB stage and time of recurrence appearance was found (Р < 0.05). TB in central tumor sites was followed by presence and higher stage of TB in peripheral tumor sites (Р < 0.05), that can be taken into account during biopsies of CRC.
Conclusions. TB is a prognostic criterion of metastasis and time of recurrence appearance for CRC рТ3N0-2M0, which is mostly typical for tumors in patients with recurrences and lethal outcome at the taken equal ratio of tumors by differen­tiation.
Comparative study of platinum electroplating to improve micro gold electrode arrays with LCP laminate
Authors: Schweigmann Michael , Kirchhoff Frank , Koch Klaus P. 
Published: January 2022

Abstract
Decoding the cellular network interaction of neurons and glial cells are important in the development of new therapies for diseases of the central nervous system (CNS). Electrophysiological in vivo studies in mice will help to understand the highly complex network. In this paper, the optimization of epidural liquid crystal polymer (LCP) electrodes for different platinum electroplating parameters are presented and compared. Constant current and pulsed current electroplating varied in strength and duration was used to decrease the electrode impedance and to increase the charge storage capacity (CSCC). In best cases, both methods generated similar results with an impedance reduction of about 99%. However, electroplating with pulsed currents was less parameter-dependent than the electroplating with constant current. The use of ultrasound was essential to generate platinum coatings without plating defects. Electrode model parameters extracted from the electrode impedance reflected the increase in surface porosity due to the electroplating processes.
State of the art of geopolymers: A review
Authors: Castillo Hengels , Collado Humberto , Droguett Thomas , Vesely Mario , Garrido Pamela , Palma Sergio 
Published: January 2022

AbstractGeopolymers emerge as an ecological alternative for construction materials. These consist of a mixture of aluminosilicate sources and an alkaline solution that dissolves the silicon and aluminum monomers that come from the source to generate a gel called N–A–S–H that will control the main properties of the geopolymer. The geopolymer stands out for having good resistance to compression, as well as good resistance to high temperatures and corrosive environments. They have great potential as a replacement for classical technologies such as concrete, however, require further applied research to determine their feasibility on an industrial scale.
Positive solutions of nonlinear fourth order iterative differential equations with two-point and integral boundary conditions
Authors: Mansouri Bouzid , Ardjouni Abdelouaheb , Djoudi Ahcene 
Published: January 2022

AbstractThis paper provides sufficient conditions to guarantee the existence, uniqueness and continuous dependence of positive solutions of a nonlinear fourth order iterative differential equations with two-point and integral boundary conditions. The main arguments are based on the Schauder fixed point theorem to prove the existence of a positive solution. As an application, we given an example to illustrate the obtained results.
La passion du café dans les publicités de Carte Noire : analyse sémiotique du goût et du désir
Authors: Seghir Atmane 
Published: January 2022

Résumé
L’intérêt pour le café ne date pas d’aujourd’hui, mais les discours promotionnels sur ce breuvage mythique ne cessent de se multiplier depuis l’arrivée d’Internet. Pour mieux comprendre le domaine spécifique des récits gustatifs (verbaux, gestuels ou visuels) qui se construisent autour de la passion pour le café, nous avons privilégié une démarche innovante en sciences du langage, la sémiotique du goût. Le site internet de la marque Carte Noire, en misant sur l’expérience gustative euphorisante et la tautologie du désir, offre un corpus approprié pour cette nouvelle approche (slogans, images, films publicitaires, textes). L’objectif de notre article est double : il consiste, d’une part, à appréhender le processus de construction des significations du récit passionnel en acte, et, d’autre part, à conceptualiser le sensible, l’imaginaire gustatif et l’hédonisme sur lesquels se basent les stratégies discursives publicitaires adjacentes.
Four weeks of electrical stimulation improves glucose tolerance in a sedentary overweight or obese Hispanic population
Authors: Galvan Michelle J , Sanchez Michael J , McAinch Andrew J , Covington Jeffrey D , Boyle Jason B , Bajpeyi Sudip 
Published: January 2022

Introduction/purpose
Most US adults (54%) do not meet the minimum exercise recommendations by the American College of Sports Medicine. Neuromuscular electrical stimulation (NMES) is a novel alternate strategy to induce muscle contraction. However, the effectiveness of NMES to improve insulin sensitivity and energy expenditure is unclear. The purpose of this study was to investigate the effects of 4 weeks of NMES on glucose tolerance in a sedentary overweight or obese population.

Methods
Participants (n  = 10; age: 36.8 ± 3.8 years; BMI = 32 ± 1.3 kg/m2) were randomized into either control or NMES group. All participants received bilateral quadriceps stimulation (12 sessions; 30 min/session; three times/week at 50 Hz and 300 µs pulse width) altering pulse amplitude to either provide low-intensity sensory level (control; tingling sensation) or at high-intensity neuromuscular level (NMES; maximum tolerable levels with visible muscle contraction). Glucose tolerance was assessed by a 3-h oral glucose tolerance test (OGTT), and substrate utilization was measured by indirect calorimetry and body composition via dual X-ray absorptiometry at baseline and after 4 weeks of NMES intervention.

Results
Control and NMES groups had comparable fasting blood glucose, glucose tolerance, substrate utilization, and muscle mass at baseline. Four weeks of NMES resulted in a significant improvement in glucose tolerance measured by OGTT, whereas no change was observed in the control group. There was no change in substrate utilization and muscle mass in both control and NMES groups.

Conclusion
NMES is a novel and effective strategy to improve glucose tolerance in an at-risk overweight or obese sedentary population.
Práctica preprofesional en la Universidad Nacional de Educación (UNAE): análisis y reflexiones de la modalidad virtual en tiempos de pandemia
Authors: Pesántez Palacios Maria Dolores , Cuenca Alvarado Paola Alexandra 
Published: January 2022

Este artículo aporta elementos de una investigación realizada en el año 2020 en la que se amplía el debate sobre la importancia de la práctica preprofesional (PP) o práctica pedagógica en modalidad presencial para la formación de docentes con perfil inclusivo. En la Universidad Nacional de Educación (UNAE) de Ecuador, las PP son consideradas el eje vertebrador de la formación profesional. En el año 2020, debido a la pandemia, la carrera de Educación Especial implementó, en el periodo académico abril-agosto 2020, la modalidad virtual para las PP con el apoyo de las unidades educativas regulares y de educación especializada. En este estudio, de corte cualitativo, se aplica el método participativo desde las perspectivas de estudiantes, tutores y tutoras profesionales (docentes de las escuelas) y tutoras y tutores académicos (docentes de la UNAE). La información se obtuvo de diversas fuentes: cuestionarios en línea, revisión documental y un grupo de discusión, participaron un total de 546 personas. Los resultados sugieren que la práctica preprofesional en modalidad virtual no garantiza los procesos de formación de calidad para los futuros docentes. Las PP en modalidad presencial propician de manera más eficiente espacios de reflexión sobre las experiencias relacionadas con la práctica y la relación que se establece entre teoría y práctica como pilares fundamentales en la formación de docentes. En cambio, las PP en modalidad virtual limitan el contacto del practicante con la realidad socioeducativa, situación que ha impedido establecer procesos adecuados de reflexión sobre la práctica docente e identificación de las necesidades y problemáticas en los diferentes contextos socioeducativos.
Palabras clave: educación inclusiva, educación especial, formación de docentes, práctica pedagógica
Los rizobios incrementan la germinación de las semillas de Coffea arabica y Coffea canephora. Segunda evidencia en Cuba
Authors: Nápoles-Vinent Sucleidi , Milanés-Riquene Silfredo , Hernández-Forte Ionel , Morales-Mena Belkis , Nápoles-Garcias María Caridad 
Published: January 2022

Introducción. La lenta y asincrónica germinación de las semillas de café afecta la obtención de plántulas e incrementa los gastos asociados a la producción. La aplicación de rizobacterias promotoras del crecimiento vegetal (PGPRs) ha mostrado ser una alternativa ante esta problemática. Objetivo. Evaluar el efecto de la inoculación de rizobios en la germinación de dos cultivares de cafeto en condiciones controladas y productivas. Materiales y métodos. Durante enero y febrero del 2020, se desarrollaron dos experimentos en la Universidad de Oriente, Cuba, en el que se emplearon diez cepas de rizobios, provenientes de leguminosas y gramíneas, y dos cultivares de cafeto de importancia económica en Cuba: Coffea arabica cultivar (cv.) Isla 5-15 y Coffea canephora Pierre ex Froehner cultivar (cv.) Robusta. Los experimentos se realizaron uno en condiciones controladas, donde la germinación de las semillas se evaluó en placas Petri y otro donde se emplearon canteros pregerminadores. En ambos experimentos se empleó un diseño completamente aleatorizado y se realizó un análisis de varianza. Resultados. En condiciones controladas, la inoculación de las cepas Rpr11, Rpr2, 1-2, ICA8001 y Can3, incrementaron el porcentaje de germinación, la energía germinativa, el índice de germinación, el índice de velocidad de germinación y el índice de vigor. En los canteros pregerminadores, los inoculantes a base de las cepas Rpr2 y Rpr11 produjeron los mayores porcentajes de emergencia y de energía de germinación. Conclusión. Las cepas Rpr2 y Rpr11 de Rhizobium, incrementaron la germinación de las semillas de dos variedades de cafeto.
La Trêve y la pesadilla de la alteridad
Authors: Retana Camilo 
Published: January 2022

En este artículo presento una propuesta interpretativa de la primera temporada de la serie belga La Trêve (2016), según la cual lo que dicha ficción escenifica es el problema de la percepción cultural de la alteridad en sus distintas versiones (racial, étnica, de clase, entre otras) así como la posible violencia ligada a ella. A partir de esa hipótesis de lectura, propongo entender el desenlace de La Trêve en términos de una apuesta narrativa con alcances políticos en la que, en lugar de resolverse la pregunta clásica del policial a propósito de la autoría del crimen en términos individuales (y por ende psicologizantes), se opta por subrayar la responsabilidad del colectivo en la protección/pérdida de toda vida, así como la actual necesidad política de trabajar porque podamos lamentar las pérdidas, incluso, de aquellos considerados distintos.
Palabras clave: programa de televisión; racismo; migración; exclusión social; violencia
Investigating errors when forecasting processes with uncertain dynamics and observation noise by the self-adjusting brown's zero-order model
Authors: Pospelov Boris , Rybka Evgenіy , Samoilov Mikhail , Krainiukov Olekcii , Kulbachko Yurii , Bezuhla Yuliia , Roianov Oleksii , Hryshko Svitlana , Krivitska Ivetta , Ivanova Valentyna 
Published: January 2022

This paper reports a study into the errors of process forecasting under the conditions of uncertainty in the dynamics and observation noise using a self-adjusting Brown's zero-order model. The dynamics test models have been built for predicted processes and observation noises, which make it possible to investigate forecasting errors for the self-adjusting and adaptive models. The test process dynamics were determined in the form of a rectangular video pulse with a fixed unit amplitude, a radio pulse of the harmonic process with an amplitude attenuated exponentially, as well as a video pulse with amplitude increasing exponentially. As a model of observation noise, an additive discrete Gaussian process with zero mean and variable value of the mean square deviation was considered. It was established that for small values of the mean square deviation of observation noise, a self-adjusting model under the conditions of dynamics uncertainty produces a smaller error in the process forecast. For the test jump-like dynamics of the process, the variance of the forecast error was less than 1 %. At the same time, for the adaptive model, with an adaptation parameter from the classical and beyond-the-limit sets, the variance of the error was about 20 % and 5 %, respectively. With significant observation noises, the variance of the error in the forecast of the test process dynamics for the self-adjusting and adaptive models with a parameter from the classical set was in the range from 1 % to 20 %. However, for the adaptive model, with a parameter from the beyond-the-limit set, the variance of the prediction error was close to 100 % for all test models. It was established that with an increase in the mean square deviation of observation noise, there is greater masking of the predicted test process dynamics, leading to an increase in the variance of the forecast error when using a self-adjusting model. This is the price for predicting processes with uncertain dynamics and observation noises.
Influence of complex treatment on the functional state of the hepatobiliary system in patients with diabetes mellitus
Authors: Valiyeva Gunay Adalat 
Published: January 2022

Liver damage in diabetes mellitus is of particular interest, since this factor significantly affects the course of the disease, the level of compensation and prognosis of the underlying disease.
The aim. To study the effect of complex treatment using ursosan on the functional state of the hepatobiliary system in patients with diabetes mellitus.
Materials and methods. The study included 30 patients with type 1 diabetes mellitus and 48 patients with type 2 diabetes. According to the duration of diabetes, patients were divided into three subgroups: a) up to five years; b) 5–10 years; c) more than 10 years. The number of patients was: 1a group – 13, 1b group – 10, 1c group – 7 people; Group 2a – 23, 2b group – 13, 2c group – 10 people. The control group consisted of 23 apparently healthy people. Ursosan was prescribed at a dose of 10-12 mg per 1 kg of body per day for 6 months. Clinical laboratory and instrumental research methods were used to study the functional state of the liver and gallbladder.
Research results. After the course of treatment with Ursosan, patients with diabetes mellitus showed normalization of protein, pigment, enzymatic metabolism and, to a lesser extent, lipid metabolism in the liver, which led to an improvement in cellular metabolism and redox processes, providing a stable course of diabetes.
Conclusions. A 6-month course of treatment with Ursosan in diabetic patients promotes long-term diabetes compensation. Patients during treatment have a decrease in cytolysis syndrome indicators (alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT), lactate dehydrogenesis (LDH)) by about 1.5 times in all 3 indicators compared to the indicators before treatment. The same trend was observed in terms of gamma-glutamine transferase (GGT) and alkaline phosphatase (ALP)
Study of hepatotoxins influence in vitro on basic biochemical indicators of liver functional state
Authors: Maloshtan Liudmyla , Storozhenko Galyna , Galuzinska Liubov , Fylymonenko Victoriia , Sadiq Omar Rashid 
Published: January 2022

An antimicrobial drug of the fluoroquinolone group, ciprofloxacin, is widely used in Ukraine. However, some researchers have noted the probable hepatotoxicity of this drug with prolonged use or use of high doses of ciprofloxacin. The aim of this study was to compare the effects of carbon tetrachloride, as a classical model of hepatocyte injury, with the effects of ciprofloxacin.
The aim of the study was to investigate the biochemical parameters of the liver when simulating toxic damage to hepatocytes with carbon tetrachloride or ciprofloxacin.
Materials and methods. The study was carried out on isolated rat hepatocytes, in whose culture medium carbon tetrachloride or ciprofloxacin was added. After incubation in the supernatant and cell homogenate, the activities of marker enzymes of cytolysis were determined: ALT, AST, γ-GTP, LF, LDH, DC and MDA.
Results. The introduction of ciprofloxacin into the culture of hepatocytes at a concentration of LC50 caused changes in biochemical parameters similar to those caused by carbon tetrachloride. Thus, an increase in ALT, AST, γ-GTP, LF, LDH, DC and MDA was observed when CCl4 or ciprofloxacin was added to the culture.
Conclusion. Incubation of rat hepatocytes with carbon tetrachloride or ciprofloxacin caused an increase in the level of enzymes and lipid peroxidation products. These parameters are indicators of gross changes in cells, which are the result of impaired keto acid formation, impaired redox reactions, impaired glycogen production