bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertainty-Aware Mixed-Variable Machine Learning for Materials Design
Authors: Zhang Hengrui , Chen Wei (Wayne) , Iyer Akshay , Apley Daniel W. , Chen Wei 
Published: August 2022

Abstract
Data-driven design shows the promise of accelerating materials discovery but is challenging due to the prohibitive cost of searching the vast design space of chemistry, structure, and synthesis methods. Bayesian Optimization (BO) employs uncertainty-aware machine learning models to select promising designs to evaluate, hence reducing the cost. However, BO with mixed numerical and categorical variables, which is of particular interest in materials design, has not been well studied. In this work, we survey frequentist and Bayesian approaches to uncertainty quantification of machine learning with mixed variables. We then conduct a systematic comparative study of their performances in BO using a popular representative model from each group, the random forest-based Lolo model (frequentist) and the latent variable Gaussian process model (Bayesian). We examine the efficacy of the two models in the optimization of mathematical functions, as well as properties of structural and functional materials, where we observe performance differences as related to problem dimensionality and complexity. By investigating the machine learning models' predictive and uncertainty estimation capabilities, we provide interpretations of the observed performance differences. Our results provide practical guidance on choosing between frequentist and Bayesian uncertainty-aware machine learning models for mixed-variable BO in materials design.
Biocompatible Amino-modificated Tantalum Nanoparticles with Catalase Activity for Sustained Intra-articular Reactive Oxygen Species Scavenging and Alleviation of MIA induced Osteoarthritis
Authors: Jiang Yunsheng , Li Tao , Yang Junjun , Wang Xin , Song Xiongbo , Chen GuangXing , Dai Gang , Li Rong , Yao Chunyan , Chen Jiajia , Gong Xiaoyuan , Yang Liu 
Published: August 2022

Abstract
Background
Osteoarthritis (OA), which involves the dysfunction of articular cartilage, is the most common form of joint disease that results in arthralgia, joint deformation and limited mobility in patients. Recent studies highlighted the vital role of oxidative stress and reactive oxygen species (ROS) during progression of OA. Therefore, attenuating oxidative stress and reducing ROS generation in articular joints represent reasonable strategies for the treatment of OA. However, in addition to instability of current antioxidants caused by fluctuation in osteoarthritic physicochemical microenvironment, poor biocompatibility and short articular joint retention also seriously hindered their clinical application.
Results
Considering the above-mentioned, the present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH2 NPs) with sustained intra-articular catalase activity. Our in vitro results showed that Ta-NH2 NPs had good biocompatibility and stability, and could protect viability and hyaline-like phenotype in chondrocyte under H2O2 challenge. In addition, the in vivo biodistribution data demonstrated sustained retention of Ta-NH2 NPs in the joint cavity, particularly in articular cartilage with unnoticed organ toxicity and abnormity in hemogram and blood biochemistry analyses. Finally, compared with catalase (CAT), Ta-NH2 NPs exhibited long-term therapeutic effect in monosodium iodoacetate (MIA) induced OA model.
Conclusion
This study explored the potential of Ta-NH2 NPs as effective ROS scavenging agent for intra-articular injection, and offered a novel strategy to achieve sustained ROS suppression using biocompatible Ta-based nano-medicine in oxidative stress related diseases.
Psychosocial and individual factors affecting Quality of Life (QoL) in patients suffering from Achilles tendinopathy: A Systematic Review
Authors: Vergés Josep , Martínez Nina , Pascual Aina , Bibas Marco , Santiña Manel , Rodas Gil 
Published: August 2022

Abstract
Background: Achilles tendinopathy (AT) is a joint condition that causes functional restrictions and pain. This condition negatively impacts patients' social connectedness and psychological well-being, reducing their quality of life (QoL). This review aims to summarise the current information on QoL in patients suffering from AT and share the reported individual factors that influence it.Methods: A systematic review was conducted at PubMed, Cochrane, Google Scholar, and PsycINFO using tendinopathy and QoL-related keywords up to November 2021. Articles were included if they compared QoL to demographic factors such as age or gender, lifestyle factors (physical activity levels), comorbidity factors (diabetes, obesity), and/or a control group.Results: 327 articles were reviewed; 21 met inclusion criteria. SF-36, EQ-5D, and VISA-A were the most common instrument used. All studies reported worse QoL in AT patients compared to a control group. When women were compared to men, women reported worse QoL. Education delivered by health care professionals improved QoL in patients with AT. Surgical AT interventions generally resulted in good to excellent outcomes, although results varied by age.Conclusion: AT has a substantial impact on QoL. In AT patients, QoL is also influenced by specific individual factors, including gender and physical activity. To better comprehend AT, QoL data is a valuable tool that allows health care professionals to implement the most effective treatment plan.
The traditional Chinese medicine monomer Ailanthone improves the therapeutic efficacy of anti-PD-L1 in melanoma cells by targeting c-Jun
Authors: Yu Pian , Wei Hui , Zhu Shiguo , Li Jie , Chen Chao , Zhang Detian , Li Yayun , Zhu Lei , Yi Xiaoqing , Liu Nian , Liu Panpan , Zhao Shuang , Chen Xiang , Peng Cong 
Published: August 2022

Abstract
Background: C-Jun, a critical component of AP-1, exerts essential functions in various tumors, including melanoma, and is believed to be a druggable target for cancer therapy. Unfortunately, no effective c-Jun inhibitors are currently approved for clinical use. The advent of immune checkpoint inhibitor (ICI) has brought a paradigm shift in melanoma therapy, but more than half of patients fail to exhibit clinical responses. The exploration of new combination therapies has become the current pursuit of melanoma treatment strategy. This study aims to screen out Chinese herbal monomers that can target c-Jun, explore the combined effect of c--Jun inhibitor and ICI, and further clarify the related molecular mechanism.Methods: We adopted a combinatorial screening strategy, including molecular docking, ligand-based online approaches and consensus quantitative structure-activity relationship (QSAR) model, to filter out c-Jun inhibitors from a traditional Chinese medicine (TCM) library. A mouse melanoma model was used to evaluate the therapeutic efficacy of monotherapy and combination therapy. Multicolor flow cytometry was employed to assess the tumor microenvironment (TME). Multiple in vitro assays were performed to verify down-streaming signaling pathway. CD4+ T-cell differentiation assay was applied to investigate Treg differentiation in vitro.Results: Ailanthone (AIL) was screened out as a c-Jun inhibitor, and inhibited melanoma cell growth by directly targeting c-Jun and promoting its degradation. Surprisingly, AIL also facilitated the therapeutic efficacy of anti-programmed death ligand-1 (PD-L1) in melanoma cells by reducing the infiltration of Tregs in TME. Additionally, AIL treatment inhibited c-Jun-induced PD-L1 expression and secretion. As a consequence, Treg differentiation was attenuated after treatment with AIL through the c-Jun/PD-L1 axis.Conclusions: Our findings identified AIL as a novel c-Jun inhibitor, and revealed its previously unrecognized anti-melanoma effects and the vital role in regulating TME by Treg suppression, which provides a novel combination therapeutic strategy of c-Jun inhibition by AIL with ICI.
A case of psoriasis treated by TCM for 20 years
Authors: LuJingjing  , Luyiqian  
Published: August 2022

Abstract
Chronic plaque psoriasis is an inflammatory disease. Due to the complex interaction of genetic and environmental factors, immune-related cytokine imbalance leads to abnormal epidermal proliferation. A 73-year-old female patient had intractable psoriasis for 20 years, whose condition improved significantly after 2 weeks of treatment with traditional Zhuang medicine. Moxibustion with medicinal thread combined with pricking and bloodletting may be a good choice for the treatment of psoriasis in the future.
Preclinical study of Therapeutic application of Sertoli Cells transplantation for treatment of Neurodegenerative Diseases: A Systematic Review
Authors: Ahmadi Houssein , Mehboudi Leila , Vatandoust Dorsa , Asadi Robabeh , Amini Abdollah 
Published: August 2022

Abstract
Progressive loss of neuronal function, brain atrophy, and abnormal protein deposition are the hallmarks of neurodegenerative diseases (NDs). NDs affect various parts of the brain and have various etiologies. Despite massive attempts to discover treatments for NDs during the past decades, there is still a need for effective therapeutic agents. Sertoli Cells (SCs), whether transplanted as allogeneic or xenogeneic cells, could offer a feasible opportunity for improving graft persistence by secreting immunomodulatory and trophic substances which shield replaced cells and tissues from the immune system. To date, there is no coherent information about the neuroprotective effects of SCs transplantation on NDs. Hence, this review tried to evaluate and report coherent information on the neuroprotective effects of these cells on NDs in preclinical settings. In this systematic review, the databases including, Scopus, PubMed, and ISI WEB of science were considered as a motor engine to search and get the relevant scientific articles and full text published between 2000 to 2022. Our search revealed 9 related articles on the effectiveness of SCs transplantation on NDs. Here, most of the evidence shows that SCs transplantation has promising effects on improving the symptoms of neurological diseases in rats. most of these relevant studies emphasize that many standardized preclinical trials should be conducted to provide reliable statistical evidence to confirm the application of SCs transplantation and the improvement of symptoms of neurodegenerative diseases.
Internalizing problems and engagement among preschool children predict the trajectories of several functional outcomes’ in a Swedish longitudinal study
Authors: Markkula Andrea , Gustafsson Berit 
Published: August 2022

Abstract
Mental health problems among children are prevalent, often found within the socioemotional domains, and tend to persist over time. Early detection could predict the need for interventions for children at risk. This study aimed to study the role of internalizing problems and engagement in a preschool setting with respect to the trajectory of several functional outcomes. Using preschool teacher estimations of a representative cohort of 845 Swedish preschool children (438 boys and 407 girls, age range 13–71 months), this study constructed risk groups based on the emotional subscale of the Strengths and Difficulties Questionnaire (SDQ) and the engagement scale derived from the Children’s Engagement Questionnaire (CEQ) at baseline. These risk groups were associated with the trajectory of WHO International Classification of Functioning, Disability and Health (ICF) (p < 0.001) SDQ (p < 0.001) SDQ-emotional subscale (p < 0.001), and CEQ (p < 0.001) over three years. Concise assessments of these risk factors in children could help predict the need for targeted interventions to ensure a positive development for children at risk.
Healthcare- Seeking Behaviours and the Impact of Covid-19 preventive Measures on Anxiety and Depression among Survivors of Covid-19 at the Buea Regional Hospital Cameroon: A Case Control Study
Authors: Yusinyu Dinayen Dieudonne , Cyrile Nkouonlack Duquesne , Georges Teuwafeu Denis , Ngwayi Shifu Ismaila , Tanue Elvis Asangbeng , Shey Nsagha Dickson , Kongnyu Njamnshi Alfred 
Published: August 2022

Abstract

BackgroundThe outbreak of the COVID-19 Pandemic led to the implementation of preventive measures to curb the spread of the virus. The fear of contracting the virus and some infection prevention and control measures have been associated with poor mental and brain health outcomes .We therefore assessed the health care- seeking behaviours and the impact of COVID-19 preventive measures on depression and anxiety among survivors of COVID-19 at the Buea Regional Hospital. Materials and MethodsThe study design was an unmatched case control study. Cases were identified from health facility records and the controls were patients who are inhabitants of same community. Data was collected using an online google questionnaire and a physical questionnaire which was self-administered .We used the Hospital Anxiety and Depression Scale to assess anxiety and depression. Data was analyzed using SPSS version 25.0 and a P-value of <0.05 was considered to be statistically significant.ResultsWe recruited 245 participants with the mean age for our participants being 32.89±13.17years. With regards to Health care -seeking behaviours 78.9 vs 75.1% (OR 1.24, CI: 0.65-2.38) sought care from the hospital among the cases and controls respectively. Survivors of COVID-19 were about 12 times more likely to seek for conventional medication as a treatment for their disease (OR 11.96, 95% CI: 6.25-22.90, p=0.000) compared to the controls. Survivors of COVID-19 presented with higher mean scores for depression and anxiety compared to the controls respectively (7.74±3.93 vs. 4.01±4.48, p=0.000), (6.84±3.87 vs. 3.10±3.75, p=0.000). Participants who wore face mask were 3 times more likely to be anxious and depressed than those who did not. Factors associated with adverse mental health outcomes were losing a love one due to COVID-19, quarantine and social isolation among the casesConclusions Health care seeking behaviour was more appropriate in the cases than the controls. COVID-19 preventive measures were associated with a negative psychosocial impact among COVID-19 survivors; thus public health officials should implement measures targeting psychosocial support of the population
Risk factors of central area lymph nodes metastasis for guiding optimal right colon cancer surgery: A retrospective multicenter study
Authors: Feng Xiaochuang , Wang Hao , Feng Bo , Chen Xinlin , Yi Xiaojiang , Zhang Qing , Li En , Zhuang Yezhong , Li Hongming , Lu Xinquan , Chen Zhaoyu , Wan Jin , Liao Weilin , Wang Jiahao , Deng Haijun , Chen Chuangqi , Diao Dechang 
Published: August 2022

Abstract
Background: D3 or CME lymphadenectomy for right colon cancer (RCC) with lymph nodes metastasis (LNM) is strongly recommended but the anatomical landmark remains controversial. Central LNM predicted poor prognosis in RCC and determined the extent of lymphadenectomy. Methods: Data for 1712 RCC patients treated with D3/CME lymphadenectomy were reviewed. These patients had been treated in 9 centers. A total of 1023 RCC patients were enrolled in the derivation cohort while 689 patients were enrolled in the validation cohort. Results: The overall central LNM incidence was 12.58% (215/1712). In the derivation cohort, univariate and multivariate cox regression analyses revealed that preoperative N staging based on CT scan (OR=7.85, 95% CI, 4.53-14.51, p<0.001), tumor differentiation (OR=0.53, 95% CI, 0.33-0.86, p=0.01) and intraoperative view of tumor movability (OR=0.53, 95% CI, 0.33-0.86, p=0.02) were significant independent factors. Areas under receiver-operating characteristic curves (AUC) for assessing central LNM in the derivation and validation cohorts were 0.802 and 0.750, respectively. The risk-scoring system for patients with RCC was also established. A score of 0 points was the optimal cut-off value for central LNM. Compared to patients in the low-risk group, patients in the high-risk group exhibited worse overall survival outcomes (p<0.001).Conclusions: The established model can be used for preoperative assessment of the risk of central LNM in RCC patients, and for determining the landmark for D3/CME lymphadenectomy, therefore might contribute to decreased therapeutic complications and improved clinical outcomes.
CuSeO4 and Cu(SeO3OH)2 ·6H2O, two novel copper– selenium(VI) oxysalts
Authors: Effenberger Herta S. , Giester Gerald , Wildner Manfred 
Published: August 2022

Abstract
The two new copper(II) salts Cu(SeO 4) and Cu(SeO 3 OH) 2 ·6H 2 O were synthesized at low-temperature hydrothermal conditions (220 °C), and room temperature, respectively. Their atomic arrangements were studied based on single-crystal X-ray investigations [P2 1 /n, a = 4.823(1), b = 8.957(2), c = 6.953(1) Å, β = 94.82(1)° Z = 4; P – 1, a = 6.133(1), b = 6.303(1), c = 8.648(2) Å, α = 70.45(1), β = 84.60(1), γ = 73.44(1)°, Z = 1]. Cu(SeO 4) adopts the MnAsO 4 structure type. It exhibits structural as well as topological relations with two formerly known isochemical compounds. They crystallize in the structure type ZnSO 4 (mineral name zincosite, Pnma) respectively NiSO 4 (Cmcm). The two minerals dravertite, CuMg(SO 4) 2 , and hermannjahnite, CuZn(SO 4) 2 , are isotypic with CuSeO 4-P2 1 /n; interestingly, also α-NaCu(PO 4) belongs to this structure type: some rotation of the XO 4 group allows a supplementary position for the Na atom. ― Cu(SeO 3 OH) 2 ·6H 2 O represents a new structure type. The protonated selenate group shows an extended Se―O h bond distance (1.695 Å) as compared to the other Se―O bonds (1.614 to 1.626 Å). One OH dipole of the three independent H 2 O molecules represents a rather free hydrogen bond. For the other H atoms, the O―H···O lengths vary from 2.585 to 2.799 Å. Interestingly, the distance O w 7···O w 7 of only 2.791 Å does not represent an edge in a coordination polyhedron and it is not preliminary involved in the hydrogen bond scheme. All Cu 2+ ions in the two title compounds are in a pronounced [4+2] coordination. The Cu 2+[4+2] atoms in Cu(SeO 4) are linked to chains along [100]; in Cu(SeO 3 OH) 2 ·6H 2 O they are not connected among each other.
Is musical engagement enough to keep the brain young?
Authors: Matziorinis Anna Maria , Gaser Christian , Koelsch Stefan 
Published: August 2022

Abstract
Music-making and engagement in music-related activities have shown procognitive benefits for healthy and pathological populations, suggesting reductions in brain aging. A previous brain aging study, using Brain Age Gap Estimation (BrainAGE), showed that professional and amateur-musicians had younger appearing brains than non-musicians. Our study sought to replicate those findings and analyze if musical training or active musical engagement was necessary to produce an age decelerating effect in a cohort of healthy individuals. We scanned 125 healthy controls and investigated if musician status, and if musical behaviours, namely Active Musical Engagement (AME) and Musical Training (MT) (as measured using the Goldsmiths Musical Sophistication Index (Gold-MSI)), had effects on brain aging. Our findings suggest that musician status is not related to BrainAGE score, although involvement in current physical activity is. Although neither MT or AME subscales of the Gold-MSI are predictive for BrainAGE scores, dispositional resilience, namely the ability to deal with challenge is related to both musical behaviours and sensitivity to musical pleasure. While the study failed to replicate the previous brain aging study, musical training and active musical engagement are related to the resilience factor of challenge. This finding may reveal how such musical behaviours can potentially strengthen the brain’s resilience to age, possibly revealing a type of neurocognitive reserve.
Chondrule-like objects and CAIs in asteroid Ryugu: earlier generations of chondrules
Authors: Nakashima Daisuke , Nakamura Tomoki , Zhang Mingming , Kita Noriko , Mikouchi Takashi , Yoshida Hideto , Enokido Yuma , Morita Tomoyo , Kikuiri Mizuha , Amano Kana , Kagawa Eiichi , Yada Toru , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Yogata Kasumi , Abe Masanao , Okada Tatsuaki , Usui Tomohiro , Yoshikawa Makoto , Saiki Takanao , Tanaka Satoshi , Nakazawa Satoru , Terui Fuyuto , Yurimoto Hisayoshi , Noguchi Takaaki , Yabuta Hikaru , Naraoka Hiroshi , Okazaki Ryuji , Sakamoto Kanako , Watanabe Sei-ichiro , Tachibana Shogo , Tsuda Yuichi 
Published: August 2022

Abstract
Chondrule-like objects and Ca-Al-rich inclusions (CAIs) are discovered in the retuned samples from asteroid Ryugu. Three chondrule-like objects, which are 16O-rich and -poor with D17O (= d17O – 0.52 × d18O) values of ~ − 23‰ and ~ − 3‰, are dominated by Mg-rich olivine, resembling what proposed as earlier generations of chondrules. The 16O-rich objects are likely to be melted amoeboid olivine aggregates that escaped from incorporation into 16O-poor chondrule precursor dust. Two CAIs composed of spinel, hibonite, and perovskite are 16O-rich with D17O of ~ − 23‰ and possibly as old as the oldest CAIs. The chondrule-like objects and CAIs (< 30 µm) are as small as those from comets, suggesting radial transport favoring smaller objects from the inner solar nebula to the formation location of the Ryugu original parent body, which is farther from the Sun and scarce in chondrules. The transported objects may have been mostly destroyed during aqueous alteration.
Haploinsufficiencies of FOXF1, FOXC2 and FOXL1 genes originated from deleted 16q24.1q24.2 fragment related with alveolar capillary dysplasia with misalignment of pulmonary veins and lymphedema–distichiasis syndrome: relationship to phenotype
Authors: Wang Xuezhen , Guo Lili , Zhang Bei , Wu Jiebin , Sun Yu , Tao Huimin , Sha Jing , Zhai Jingfang , Liu Min 
Published: August 2022

AbstractObjective:We describe a fetus with a 2.12-Mb in 16q terminal deletion which associated with alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) and lymphedema–distichiasis syndrome (LDS); we also review other similar published studies and discuss the genetype-phenotype correlation.Methods:Amniotic fluid of the fetus was collected for karyotype analysis and copy number variation sequencing (CNV-seq) after informed consent.Results:The fetal karyotype was 46,XX; the result of CNV-seq showed that there was an approximately 2.12-Mb deletion in 16q24.1-q24.2 (85220000-87340000) indicating pathogenicity.Conclusion:Molecular genetic testing should be recommend as a first line diagnostic tool for suspected ACD/MPV and / or LDS or other genetic syndromes for the fetuses with structural abnormalities in clinical practice.