bluuebunny/crossref_metadata_2025_split huggingface dataset:
A national quality improvement study identifying and addressing cancer screening deficits due to the COVID‐19 pandemic
Authors: Joung Rachel H. , Nelson Heidi , Mullett Timothy W. , Kurtzman Scott H. , Shafir Sarah , Harris James B. , Yao Katharine A. , Brajcich Brian C. , Bilimoria Karl Y. , Cance William G. 
Published: March 2022

BackgroundCancer‐related deaths over the next decade are expected to increase due to cancer screening deficits associated with the coronavirus disease 2019 (COVID‐19) pandemic. Although national deficits have been quantified, a structured response to identifying and addressing local deficits has not been widely available. The objectives of this report are to share preliminary data on monthly screening deficits in breast, colorectal, lung, and cervical cancers across diverse settings and to provide online materials from a national quality improvement (QI) study to help other institutions to address local screening deficits.MethodsThis prospective, national QI study on Return‐to‐Screening enrolled 748 accredited cancer programs in the United States from April through June 2021. Local prepandemic and pandemic monthly screening test volumes (MTVs) were used to calculate the relative percent change in MTV to describe the monthly screening gap.ResultsThe majority of facilities reported monthly screening deficits (colorectal cancer, 80.6% [n = 104/129]; cervical cancer, 69.0% [n = 20/29]; breast cancer, 55.3% [n = 241/436]; lung cancer, 44.6% [n = 98/220]). Overall, the median relative percent change in MTV ranged from –17.7% for colorectal cancer (interquartile range [IQR], –33.6% to –2.8%), –6.8% for cervical cancer (IQR, –29.4% to 1.7%), –1.6% for breast cancer (IQR, –9.6% to 7.0%), and 1.2% for lung cancer (IQR, –16.9% to 19.0%). Geographic differences were not observed. There were statistically significant differences in the percent change in MTV between institution types for colorectal cancer screening (P = .02).ConclusionCancer screening is still in need of urgent attention, and the screening resources made available online may help facilities to close critical gaps and address screenings missed in 2020.Lay Summary

Question: How can the effects of the coronavirus disease 2019 pandemic on cancer screening be mitigated?

Findings: When national resources were provided, including methods to calculate local screening deficits, 748 cancer programs promptly enrolled in a national Return‐to‐Screening study, and the majority identified local screening deficits, most notably in colorectal cancer. Using these results, 814 quality improvement projects were initiated with the potential to add 70,000 screening tests in 2021.

Meaning: Cancer screening is still in need of urgent attention, and the online resources that we provide may help to close critical screening deficits.
SISTA: Learning Optimal Transport Costs under Sparsity Constraints
Authors: Carlier Guillaume , Dupuy Arnaud , Galichon Alfred , Sun Yifei 
Published: March 2022

AbstractIn this paper, we describe a novel iterative procedure called SISTA to learn the underlying cost in optimal transport problems. SISTA is a hybrid between two classical methods, coordinate descent (“S”‐inkhorn) and proximal gradient descent (“ISTA”). It alternates between a phase of exact minimization over the transport potentials and a phase of proximal gradient descent over the parameters of the transport cost. We prove that this method converges linearly, and we illustrate on simulated examples that it is significantly faster than both coordinate descent and ISTA. We apply it to estimating a model of migration, which predicts the flow of migrants using country‐specific characteristics and pairwise measures of dissimilarity between countries. This application demonstrates the effectiveness of machine learning in quantitative social sciences. © 2022 Wiley Periodicals LLC.
Recent Approaches in the Catalytic Transformation of Biomass‐Derived 5‐Hydroxymethylfurfural into 2,5‐Diformylfuran
Authors: Hoang Tran Phuong 
Published: March 2022

AbstractThe conversion of biomass into a great variety of valuable chemicals, polymers, and fuels gives a sustainable alternative for the insufficiency of non‐renewable fossil fuel resources and reduces environmental pollution. 5‐Hydroxymethylfurfural (HMF), converted from sustainable carbohydrates, is a significant building block chemical, and the selective oxidation of HMF into 2,5‐diformylfuran (DFF) presents an ongoing challenge. DFF is a versatile platform molecule derived from biomass and has promising application in pharmaceuticals and polymers. This Review provides an overview of the latest developments of efficient catalytic systems for the sustainable conversion of HMF to DFF.
A New Family of Renewable Thermosets: Kraft Lignin Poly‐adipates
Authors: Di Francesco Davide , Rigo Davide , Reddy Baddigam Kiran , Mathew Aji P. , Hedin Niklas , Selva Maurizio , Samec Joseph S. M. 
Published: March 2022

AbstractThermosetting polymeric materials have advantageous properties and are therefore used in numerous applications. In this study, it was hypothesized and ultimately shown that thermosets could be derived from comparably sustainable sub‐components. A two‐step procedure to produce a thermoset comprising of Kraft lignin (KL) and the cross‐linker adipic acid (AdA) was developed. The cross‐linking was activated by means of an acetylating agent comprising isopropenyl acetate (IPA) to form a cross‐linking mixture (CLM). The cross‐linking was confirmed by FTIR and solid‐state NMR spectroscopy, and the esterification reactions were further studied using model compounds. When the KL lignin was mixed with the CLM, partial esterification occurred to yield a homogeneous viscous liquid that could easily be poured into a mold, as the first step in the procedure. Without any additions, the mold was heated and the material transformed into a thermoset by reaction of the two carboxylic acid‐derivatives of AdA and KL in the second step.
Energy optimized resource and power allocation in an uplink‐based underlay device‐to‐device communication for 5G network
Authors: Nagarajan Rajkumar , Vali Mohamad Noor Mohammed 
Published: March 2022

SummaryFifth generation (5G) and beyond fifth generation (B5G) networks are expected to provide more energy efficiency, spectral efficiency, and very high data rate with minimum latency to an ultradense environment. To meet the requirements of 5G and B5G standards, the network infrastructure can be network‐centric approach where the network is modified with respect to new radio signals and waveforms. The other approach is device centric where the existing network infrastructure can be efficiently utilized. Device‐to‐Device (D2D) communication is a key technique in device centric approach that supports 5G and B5G networks. We propose a Sequential Best Throughput Seek Algorithm (SBTSA), to compute the interference threshold for each Cellular User Equipment (CUE), and optimum resource blocks (RBs) are assigned to D2D pairs which provide best throughput to D2D pairs without affecting the Quality of Service (QoS) of the CUEs. The transmit power is optimized using genetic algorithm (GA) to effectively handle the interference between cellular users and D2D pairs. Proposed algorithm is compared with existing methods, and best results are obtained in terms of system throughput, battery utilization and energy efficiency.
In sync with your child: The potential of parent–child electroencephalography in developmental research
Authors: Turk Elise , Vroomen Jean , Fonken Yvonne , Levy Jonathan , van den Heuvel Marion I. 
Published: March 2022

AbstractHealthy interaction between parent and child is foundational for the child's socioemotional development. Recently, an innovative paradigm shift in electroencephalography (EEG) research has enabled the simultaneous measurement of neural activity in caregiver and child. This dual‐EEG or hyperscanning approach, termed parent–child dual‐EEG, combines the strength of both behavioral observations and EEG methods. In this review, we aim to inform on the potential of dual‐EEG in parents and children (0–6 years) for developmental researchers. We first provide a general overview of the dual‐EEG technique and continue by reviewing the first empirical work on the emerging field of parent–child dual‐EEG, discussing the limited but fascinating findings on parent–child brain‐to‐behavior and brain‐to‐brain synchrony. We then continue by providing an overview of dual‐EEG analysis techniques, including the technical challenges and solutions one may encounter. We finish by discussing the potential of parent–child dual‐EEG for the future of developmental research. The analysis of multiple EEG data is technical and challenging, but when performed well, parent–child EEG may transform the way we understand how caregiver and child connect on a neurobiological level. Importantly, studying objective physiological measures of parent–child interactions could lead to the identification of novel brain‐to‐brain synchrony markers of interaction quality.
Environmental enrichment decreases anxiety‐like behavior in zebrafish larvae
Authors: Gatto Elia , Dadda Marco , Bruzzone Matteo , Chiarello Enrico , De Russi Gaia , Maschio Marco Dal , Bisazza Angelo , Lucon‐Xiccato Tyrone 
Published: March 2022

AbstractThe development of anxiety disorders is often linked to individuals’ negative experience. In many animals, development of anxiety‐like behavior is modeled by manipulating individuals’ exposure to environmental enrichment. We investigated whether environmental enrichment during early ontogenesis affects anxiety‐like behavior in larval zebrafish. Larvae were exposed from hatching to either an environment enriched with 3D‐objects of different color and shape or to a barren environment. Behavioral testing was conducted at different intervals during development (7, 14, and 21 days post‐fertilization, dpf). In a novel object exploration test, 7 dpf larvae of the two treatments displayed similar avoidance of the visual stimulus. However, at 14 and 21 dpf, larvae of the enriched environment showed less avoidance, indicating lower anxiety response. Likewise, larvae of the two treatments demonstrated comparable avoidance of a novel odor stimulus at 7 dpf, with a progressive reduction of anxiety behavior in the enriched treatment with development. In a control experiment, larvae treated before 7 dpf but tested at 14 dpf showed the effect of enrichment on anxiety, suggesting an early determination of the anxiety phenotype. This study confirms a general alteration of zebrafish anxiety‐like behavior due to a short enrichment period in first days of life.
Bees in the six: Determinants of bumblebee habitat quality in urban landscapes
Authors: Conflitti Ida M. , Arshad Imrit Mohammad , Morrison Bandele , Sharma Sapna , Colla Sheila R. , Zayed Amro 
Published: March 2022

AbstractWith growing urbanization, it is becoming increasingly important to design cities in a manner that sustains and enhances biodiversity and ecosystem services. Native bees are critical pollinators that have experienced substantive declines over the past several decades. These declines have captured the attention of the public, particularly urbanites, prompting a large interest in protecting pollinators and their habitats in cities across North America and Europe. Unfortunately, we currently lack research about specific features of urban environments that can enhance the fitness of pollinators. We carried out an intensive study of Bombus impatiens, the Common Eastern Bumblebee, in the city of Toronto (Canada's largest city), to better understand landscape parameters that provide high‐quality habitat for this species and likely other generalist bees. We divided the city into 270 grid cells and sampled a large number of worker bees, which were then genotyped at twelve hypervariable microsatellite loci. The genetic data allowed us to quantify the effective number of colonies and foraging distance for bumblebees in our study area. We then asked how the city's landscape and human population demography and income are associated with the availability of high‐quality habitat for B. impatiens. Several aspects of Toronto's landscape influenced colony density and foraging range. Urbanization had a clear effect on both colony density and foraging distance of workers. On the other hand, functional (i.e., not cosmetic) green space was often associated with higher quality habitats for bumblebees. Our study suggests several planning strategies to enhance habitat quality for bumblebees and other pollinators in cities.
Neutralizing antibodies to SARS‐CoV‐2 Omicron variant after third mRNA vaccination in health care workers and elderly subjects
Authors: Haveri Anu , Solastie Anna , Ekström Nina , Österlund Pamela , Nohynek Hanna , Nieminen Tuomo , Palmu Arto A. , Melin Merit 
Published: March 2022

AbstractThe emergence of SARS‐CoV‐2 Omicron variant (B.1.1.529) with major spike protein mutations has raised concern over potential neutralization escape and breakthrough infections among vaccinated and previously SARS‐CoV‐2‐infected subjects. We measured cross‐protective antibodies against variants in health care workers (HCW, n = 20) and nursing home residents (n = 9) from samples collected at 1–2 months, following the booster (3rd) dose. We also assessed the antibody responses in subjects infected before the Omicron era (n = 38) with subsequent administration of a single mRNA vaccine dose. Following booster vaccination, HCWs had high IgG antibody concentrations to the spike protein and neutralizing antibodies (NAb) were detectable against all variants. IgG concentrations among the elderly remained lower, and some lacked NAbs against the Beta and Omicron variants. NAb titers were significantly reduced against Delta, Beta, and Omicron compared to WT virus regardless of age. Vaccination induced high IgG concentrations and variable titers of cross‐reactive NAbs in previously infected subjects, whereas NAb titers against Omicron were barely detectable 1 month postinfection. High IgG concentrations with cross‐protective neutralizing activity were detected after three Coronavirus Disease 2019 (COVID‐19) vaccine doses in HCWs. However, lower NAb titers seen in the frail elderly suggest inadequate protection against Omicron breakthrough infections, yet protection against severe COVID‐19 is expected.
Temporal Trends of Organochlorine and Perfluorinated Contaminants in a Terrestrial Raptor in Northern Europe Over 34 years (1986–2019)
Authors: Bustnes Jan Ove , Bårdsen Bård-Jørgen , Herzke Dorte , Bangjord Georg , Bourgeon Sophie , Fritsch Clementine , Eulaers Igor 
Published: March 2022

Abstract
Fourteen legacy organochlorine (OC) contaminants and 12 perfluoroalkyl substances (PFASs) were measured in eggs of tawny owls (Strix alueco) in central Norway (1986–2019). We expected OCs to have reached stable equilibrium levels due to bans, and that recent phase-out of some PFASs would have slowed the increase of these compounds. ∑OC comprised on average approximately 92% of the measured compounds, whereas ∑PFAS accounted for approximately 8%. However, whereas the ∑OC to ∑PFAS ratio was approximately 60 in the first 5 years of the study, it was only approximately 11 in the last 5 years. Both OC pesticides and polychlorinated biphenyls (PCBs) showed substantial declines over the study period (~85%–98%): hexachlorocyclohexanes and chlordanes seemed to be levelling off, whereas p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) and hexachlororbenzene (HCB), and most PCB congeners still seemed to decline at a more or less constant rate. While the concentration of perfluorooctane sulfonic acid (PFOS), the dominating PFAS, was reduced by approximately 43%, other perfluorinated sulfonates (PFSAs) showed only minor changes. Moreover, the median concentrations of seven perfluorinated carboxylic acids (PFCAs) increased approximately five-fold over the study period. Perfluorononanoic acid and perfluoroundecanoate acid, however, seemed to be levelling off in recent years. In contrast, perfluorododecanoic acid, perfluorodecanoate acid, perfluorotridecanoic acid, and perfluorotetradecanoic acid seemed to increase more or less linearily. Finally, perfluorooctanoic acid (PFOA) was increasingly likely to be detected over the study period. Hence, most legacy OCs and PFOS have not reached a lower threshold with stable background levels, and voluntary elimination of perfluoroalkyl carboxylates still has not resulted in declining levels in tawny owls in central Norway. Environ Toxicol Chem 2022;41:1508–1519. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Aggregation‐induced emission luminogens for augmented photosynthesis
Authors: Liu Haixiang , Yan Neng , Bai Haotian , Kwok Ryan T. K. , Tang Ben Zhong 
Published: March 2022

AbstractPhotosynthesis is promising in sequestrating carbon dioxide and providing food and biofuel. Recent findings have shown that luminescent materials could shift the wavelength of light to a more usable range for augmented photosynthesis. Among them, aggregation‐induced emission luminogens (AIEgens) have advantages of efficient light conversion, high biocompatibility, large Stokes’ shift, and so on. In this perspective, emerging reports of augmented photosynthesis with luminescent materials, especially the AIEgens are included. We emphasized the spectra shift characteristics, material formation, and sustainable development based on augmented photosynthesis.
Detection and isolation of typical gut indigenous bacteria in mice fed corn starch, bread flour or whole wheat flour
Authors: Takei Natsumi , Kuda Takashi , Handa Natsumi , Takahashi Hajime , Kimura Bon 
Published: March 2022

AbstractWhole wheat flour (WWF) is regarded to have preventive effects on life‐style diseases. Detection, identification and isolation of WWF‐responsive gut indigenous bacteria (RIB) should reveal the gut microbiota‐mediated properties of WWF. To confirm the existence and roles of bread flour (BF)‐ and WWF‐RIB, Institute of Cancer Research mice were fed a diet containing corn starch (CS), BF or WWF as the starch source for 14 days. WWF increased in defecation. BF‐ and WWF‐RIB were detected using 16S rRNA(V4) gene amplicon sequencing. Amplicon sequence variants (ASVs) of Lactobacillus johnsonii‐like bacteria in both BF and WWF groups (respective relative abundance: 9.3% and 9.4%) were higher than those in the CS group (0.5%). While Lactobacillus intestinalis‐ and Limosilactobacillus reuteri‐like bacteria ASVs were high in the WWF group (0.8% and 1.7%, respectively), these were not detected in the CS group. In contrast, ASVs of Blautia‐, Clostridium saudiense/disporicum‐, Lactobacillus murinus‐, Muribaculaceae‐, Phocaeicola vulgatus‐ and Bifidobacterium pseudolongum‐like bacteria in CS‐fed mice were higher than those in the other mice. Among these BF‐ and WWF‐RIB, L. johnsonii and L. reuteri could be isolated. Further studies on the isolation of the RIB from the human gut are required.
Diet and human reproductive system: Insight of omics approaches
Authors: Ma Xiaoling , Wu Luming , Wang Yinxue , Han Shiqiang , El‐Dalatony Marwa M. , Feng Fei , Tao Zhongbin , Yu Liulin , Wang Yiqing 
Published: March 2022

AbstractNutrition and lifestyle have a great impact on reproduction and infertility in humans, as they are essential for certain processes such as implantation, placental growth, angiogenesis, and the transfer of nutrients from the mother to the fetus. The aim of this review is to provide the interconnection between nutrition and reproductive health through the insight of omics approaches (including metabolomics and nutrigenomics). The effect of various macronutrients, micronutrients, and some food‐associated components on male and female reproduction was discussed. Recent research work was collected through database search from 2010 to 2020 to identify eligible studies. Alterations of metabolic pathways in pregnant women were deliberated with an emphasis on different strategies of lifestyle and dietary interventions. Several nutritional methods, which are important for embryonic and child neurological development, nutritional supplements to lactation, and improved gestational length along with birth weight have been emphasized. Considerable advances in omics strategies show potential technological development for improving human reproductive health.
Morphological and chemical characterizations of jujube (Ziziphus jujuba Mill.) to select superior accessions
Authors: Khadivi Ali , Beigi Fatemeh 
Published: March 2022

AbstractThe fruits of jujube (Ziziphus jujuba Mill.) are consumed worldwide as food and herbal medicine because of their impact on human health and benefits. Here, phenotypic and chemical variation of this species was investigated to select superior accessions. The selected accessions showed significant differences based on the measured characteristics. Fresh fruit weight varied from 2.72 to 6.42 g with an average of 4.54, while dry fruit weight ranged from 0.89 to 2.57 g with an average of 1.55. Total phenolic content ranged from 1.69 to 14.05 mg gallic acid equivalent (GAE) g−1 fresh weight (FW) and total flavonoid content varied from 0.25 to 2.01 mg quercetin equivalents (QE) g−1 FW. Total anthocyanin content varied from 5.98 to 76.32 µg CyE g−1 FW. Radical scavenging activity (2,2‐diphenyl‐1‐picryl‐hydrazyl‐hydrate [DPPH]) ranged from 1.32 to 5.82 mg ascorbic acid equivalents (AsAE) g−1 FW, while ferric reducing antioxidant power (FRAP) varied from 35.37 to 93.35 µM FeSO4. The present study showed high diversity in morphological and chemical properties of jujube accessions. Based on the traits related to fruit quality such as fruit weight, fruit skin color, and fruit flavor, as well as in terms of chemical characteristics related to medicinal properties such as total anthocyanin content and antioxidant activity, 13 accessions were superior and are recommended to use in breeding programs. The commercial orchard of those best accessions should be extensively constructed to take advantage of the high yield of this tree as a crop and its medicinal properties.
Fe3O4@PDA/MIL‐101(Cr) as magnetic solid‐phase extraction sorbent for mycotoxins in licorice prior to ultrahigh‐performance liquid chromatography‐tandem mass spectrometry analysis
Authors: Tang Zhentao , Han Qingrong , Yu Gang , Liu Fei , Tan Yuzhu , Peng Cheng 
Published: March 2022

AbstractMagnetic solid‐phase extraction (MSPE) strategy based on the Fe3O4@PDA/MIL‐101(Cr) has been proposed to separate and purify five common mycotoxins in licorice, including aflatoxin B1, aflatoxin G1, sterigmatocystin, zearalenone, and ochratoxin A. Integrating the MSPE and solid–liquid extraction/partitioning, a modified QuEChERS was established to adapt to the complex licorice samples. The Fe3O4@PDA/MIL‐101(Cr) was successfully synthesized and characterized by Fourier transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen adsorption–desorption isotherms. Sorbents with superior advantages for exclusion of matrix interference and extraction of target analytes in a short time were obtained, according to their ability of magnetic separation, high surface area (287.75 m2/g), large pore volume (0.61 cm3/g), and nanosized structure with mesopores. Prior to analysis with ultrahigh‐performance liquid chromatography‐tandem mass spectrometry (UHPLC‐MS/MS), several key parameters that would affect the sorbents’ extraction efficiency were extensively investigated. Under the optimized conditions, the practicality of the developed method for analysis of mycotoxins in licorice samples was confirmed by adequate linearity (R2 ≥ 0.9967), high sensitivity (LODs and LOQs, respectively, in the ranges 0.01–0.09 and 0.02–0.30 μg/kg), acceptable recovery (78.53%–116.28%), satisfactory reusability, and good interbatch precision of the sorbents (RSDs in the ranges 6.70%–11.20% and 6.02%–10.35%, respectively). The results indicated that the established method was feasible and reliable for the environment‐friendly and rapid screening of mycotoxins in complex licorice samples.