bluuebunny/crossref_metadata_2025_split huggingface dataset:
An observational thoracic radiographic study of aortic remodeling in dogs with confirmed systemic hypertension
Authors: Holland Merrilee , Hudson Judith , Hofmeister Erik 
Published: January 2022

AbstractSustained systemic hypertension (SH) has been shown to cause target organ damage to various tissues in dogs and cats, including the aorta. Aortic dilatation occurs most commonly secondary to SH in people and develops prior to an aortic aneurysm. Our hypothesis was that blinded reviewers could be trained to recognize variable alterations of aortic shape and size on thoracic radiographs of canine patients with SH. A retrospective, observational, cross‐sectional study was performed with three blinded reviewers evaluating thoracic radiographic images of 21 dogs with normal blood pressure compared to 145 dogs with system hypertension. Lateral radiographs showed variable aortic undulation and disproportionate enlargement of a portion of the aorta between the ascending and proximal descending aorta compared to the descending aorta just cranial to the diaphragm. On orthogonal projections, the aortic arch to proximal descending aorta bowed laterally similar to changes reported in people with the formation of an aortic “knob.” After completing a training module, reviewers of the thoracic images had a 74% agreement with Fleiss’ Kappa of 0.50 indicating moderate agreement recognizing SH changes to the thoracic aorta. The more experienced blinded reviewers had accuracies of 85% and 80% for identifying systemic hypertension, slightly better than the less experienced reviewer at 76%. The ratio of thoracic cavity width to aortic knob width was significantly different between the groups (median ratio 3.4 SH vs 4.1 normal). Evidence of target organ damage (TOD) to the thoracic aorta may prompt earlier recognition and treatment for systemic hypertension.
Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease Study 2017
Authors: Sun Yi , Chen Aiming , Zou Minjie , Zhang Yichi , Jin Ling , Li Yi , Zheng Danying , Jin Guangming , Congdon Nathan 
Published: January 2022

ObjectiveTo estimate global prevalence of blindness and vision loss caused by glaucoma, and to evaluate the impact of socioeconomic factors on it.DesignA population-based observational study.SettingThe prevalence of blindness and vision loss due to glaucoma were obtained from the Global Burden of Disease Study 2017 database. The Human Development Index (HDI), inequality-adjusted HDI and other socioeconomic data were acquired from international open databases.Main outcome measuresThe prevalence of blindness and vision loss due to glaucoma by age, gender, subregion and Socio-Demographic Index (SDI) levels. Multiple linear regression analysis was performed to explore the associations between the prevalence and socioeconomic indicators.ResultsThe overall age-standardised prevalence of blindness and vision loss due to glaucoma worldwide was 81.5 per 100 000 in 1990 and 75.6 per 100 000 in 2017. In 2017, men had a higher age-standardised prevalence than women (6.07% vs 5.42%), and the worldwide prevalence increased with age, from 0.5 per 100 000 in the 45–49 year age group to 112.9 per 100 000 among those 70+. Eastern Mediterranean and African regions had the highest prevalence during the whole period, while the Americas region had the lowest prevalence. The prevalence was highest in low-SDI and low-income regions while lowest in high-SDI and high-income regions over the past 27 years. Multiple linear regression showed cataract surgery rate (β=−0.01, p=0.009), refractive error prevalence (β=−0.03, p=0.024) and expected years of schooling (β= -8.33, p=0.035) were associated with lower prevalence, while gross national income per capita (β=0.002, p<0.001) was associated with higher prevalence.ConclusionsLower socioeconomic levels and worse access to eyecare services are associated with higher prevalence of glaucoma-related blindness and vision loss. These findings provide evidence for policy-makers that investments in these areas may reduce the burden of the leading cause of irreversible blindness.
Assessing geographical and economic inequalities in caesarean section rates between the districts of Bihar, India: a secondary analysis of the National Family Health Survey
Authors: Shukla Minal , Mohan Monali , van Duinen Alex , Gadgil Anita , Bakker Juul , Bhushan Pranav , Roy Nobhojit 
Published: January 2022

BackgroundIn Bihar, one of the most populous and poorest states in India, caesarean sections have increased over the last decade. However, an aggregated caesarean section rate at the state level may conceal inequities at the district level.ObjectivesThe primary aim of this study was to analyse the inequalities in the geographical and socioeconomic distribution of caesarean sections between the districts of Bihar. The secondary aim was to compare the contribution of free-for-service government-funded public facilities and fee-for-service private facilities to the caesarean section rate.SettingBihar, with a population in the 2011 census of approximately 104 million people, has a low GDP per capita (US$610), compared with other Indian states. The state has the highest crude birth rate (26.1 per 1000 population) in India, with one baby born every two seconds. Bihar is divided into 38 administrative districts, 101 subdivisions and 534 blocks. Each district has a district (Sadar) hospital, and six districts also have one or more medical college hospitals.MethodsThis retrospective secondary data analysis was based on open-source national datasets from the 2015 and 2019 National Family Health Surveys, with respective sample sizes of 45 812 and 42 843 women aged 15–49 years.ParticipantsSecondary data analysis of pregnant women delivering in public and private institutions.ResultsThe caesarean section rate increased from 6.2% in 2015 to 9.7% in 2019 in Bihar. Districts with a lower proportion of poor population had higher caesarean section rates (R2=0.45) among all institutional births, with 10.3% in private and 2.9% in public facilities. Access to private caesarean sections decreased (R2=0.46) for districts with poorer populations.ConclusionMarked inequalities exist in access to caesarean sections. The public sector needs to be strengthened to improve access to obstetric services for those who need it most.
Characteristics of anatomical difficulty for cryoballoon ablation: insights from CT
Authors: Hayashi Takahiro , Murakami Masato , Saito Shigeru , Iwasaki Kiyotaka 
Published: January 2022

BackgroundThe limited availability of balloon sizes for cryoballoon leads to anatomical limitations for pulmonary vein (PV) isolation. We conducted a comprehensive systematic analysis on procedural success rate, atrial fibrillation (AF) recurrence rate and complications of cryoballoon ablation in association with the anatomy of the left atrium and PV based on preprocedural CT to gain insights into proper treatments of patients with AF using cryoballoon.MethodA systematic search of literature databases, including PubMed, Web of Science and Cochrane Library, from the inception of each database through February 2021 was conducted. Search keywords included ‘atrial fibrillation’, ‘cryoballoon ablation’ and ‘anatomy’.ResultsOverall, 243 articles were identified. After screening, 16 articles comprising 1396 patients were included (3, 5 and 8 for acute success, AF recurrence and complications, respectively). Regarding acute success and AF recurrences, thinner width of the left lateral ridge, higher PV ovality, PV ostium-bifurcation distance, shorter distance from the non-coronary cusp to inferior PVs, shallower angle of right PVs against the atrial septum and larger right superior PV (RSPV) were associated with poor outcomes. Regarding complications, shorter distance between the RSPV ostium and the right phrenic nerve, larger RSPV-left atrium angle, larger RSPV area and smaller right carina width were associated with incidences of phrenic nerve injury.ConclusionThis study elucidated several key anatomical features of PVs possibly affecting acute success, AF recurrence and complications in patients with AF using cryoballoon ablation. CT analysis has helped to describe benefits and anatomical limitations for cryoballoon ablation.
Prognostic factors in children with acute fulminant myocarditis receiving venoarterial extracorporeal membrane oxygenation
Authors: Sun Mingwei , Zong Qing , Ye Li Fen , Fan Yong , Yang Lijun , Lin Ru 
Published: January 2022

BackgroundPediatric acute fulminant myocarditis (AFM) is a very dangerous disease that may lead to acute heart failure or even sudden death. Previous reports have identified some prognostic factors in adult AFM; however, there is no such research on children with AFM on venoarterial extracorporeal membrane oxygenation (VA-ECMO). This study aimed to find relevant prognostic factors for predicting adverse clinical outcomes.MethodsA retrospective analysis was performed in an affiliated university children’s hospital with consecutive patients receiving VA-ECMO for AFM from July 2010 to November 2020. These children were classified into a survivor group (n=33) and a non-survivor group (n=8). Patient demographics, clinical events, laboratory findings, and electrocardiographic and echocardiographic parameters were analyzed.ResultsPeak serum creatinine (SCr) and peak creatine kinase isoenzyme MB during ECMO had joint predictive value for in-hospital mortality (p=0.011, AUC=0.962). Based on multivariable logistic regression analysis, peak SCr level during ECMO support was an independent predictor of in-hospital mortality (OR=1.035, 95% CI 1.006 to 1.064, p=0.017, AUC=0.936, with optimal cut-off value of 78 μmol/L).ConclusionTissue hypoperfusion and consequent end-organ damage ultimately hampered the outcomes. The need for left atrial decompression indicated a sicker patient on ECMO and introduced additional risk for complications. Earlier and more cautious deployment would likely be associated with decreased risk of complications and mortality.
The effect of sea surface temperature on the structure and connectivity of species landings interaction networks in a multispecies recreational fishery
Authors: Blincow Kayla M. , Semmens Brice X. 
Published: January 2022

Multispecies fisheries, particularly those that routinely adapt the timing, location, and methods of fishing to prioritize fishery targets, present a challenge to traditional single-species management approaches. Efforts to develop robust management for multispecies fisheries require an understanding of how priorities drive the network of interactions between catch of different species, especially given the added challenges presented by climate change. Using 35 years of landings data from a southern California recreational fishery, we leveraged empirical dynamic modelling methods to construct causal interaction networks among the main species targeted by the fishery. We found strong evidence for dependencies among species landings time series driven by apparent hierarchical catch preference within the fishery. In addition, by parsing the landings time series into anomalously cool, normal, and anomalously warm regimes (the last reflecting ocean temperatures anticipated by 2040), we found that network complexity was highest during warm periods. Our findings suggest that as ocean temperatures continue to rise, so too will the risk of unintended consequences from single-species management in this multispecies fishery.
Sedimentation associated with glaciovolcanism: a review
Authors: Smellie John Laidlaw 
Published: January 2022

Abstract

Three discrete categories of sedimentary deposits are associated with glaciovolcanism: englacial cavity, jökulhlaup and lahar. Englacial cavity deposits are found in water-filled chambers in the lee of active glaciovolcanoes or at a locus of enhanced geothermal heat flux. The cavities provide a depocentre for the accumulation of debris, either abundant fresh juvenile debris with sparse dropstones (associated with active glaciovolcanism) or polymict basal glacial debris in which dropstones are abundant (associated with geothermal hot spots). Described examples are uncommon. By contrast, volcanogenic jökulhlaup deposits are abundant, mainly in Iceland, where they form extensive sandar sequences associated with ice-
covered
volcanoes. Jökulhlaups form as a result of the sudden subglacial discharge of stored meltwater. Analogous deposits known as glaciovolcanic sheet-like sequences represent the ultra-proximal lateral equivalents deposited under the ice. Glaciovolcanic lahars are associated with ice-
capped
volcanoes. They form as a result of explosive eruptions through relatively thin ice or following dome collapse, and they trigger mainly supraglacial rather than subglacial meltwater escape. Sediment transport and depositional processes are similar in jökulhaups and lahars and are dominated by debris flow and hyperconcentrated or supercritical flow modes during the main flood stage, although the proportions of the principal lithofacies are different.
ZEB2
Shapes the Epigenetic Landscape of Atherosclerosis
Authors: Cheng Paul , Wirka Robert C. , Shoa Clarke Lee , Zhao Quanyi , Kundu Ramendra , Nguyen Trieu , Nair Surag , Sharma Disha , Kim Hyun-jung , Shi Huitong , Assimes Themistocles , Brian Kim Juyong , Kundaje Anshul , Quertermous Thomas 
Published: January 2022

Background:
Smooth muscle cells (SMCs) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the atherosclerotic plaque. To better understand the epigenetic and transcriptional mechanisms that mediate these cell state changes, and how they relate to risk for coronary artery disease (CAD), we have investigated the causality and function of transcription factors at genome-wide associated loci.

Methods:
We used CRISPR-Cas 9 genome and epigenome editing to identify the causal gene and cells for a complex CAD genome-wide association study signal at 2q22.3. Single-cell epigenetic and transcriptomic profiling in murine models and human coronary artery smooth muscle cells were used to understand the cellular and molecular mechanism by which this CAD risk gene exerts its function.

Results:

CRISPR-Cas 9 genome and epigenome editing showed that the complex CAD genetic signals within a genomic region at 2q22.3 lie within smooth muscle long-distance enhancers for
ZEB2
, a transcription factor extensively studied in the context of epithelial mesenchymal transition in development of cancer. Zeb2 regulates SMC phenotypic transition through chromatin remodeling that obviates accessibility and disrupts both Notch and transforming growth factor β signaling, thus altering the epigenetic trajectory of SMC transitions. SMC-specific loss of
Zeb2
resulted in an inability of transitioning SMCs to turn off contractile programing and take on a fibroblast-like phenotype, but accelerated the formation of chondromyocytes, mirroring features of high-risk atherosclerotic plaques in human coronary arteries.

Conclusions:

These studies identify
ZEB2
as a new CAD genome-wide association study gene that affects features of plaque vulnerability through direct effects on the epigenome, providing a new therapeutic approach to target vascular disease.
“Doomed to Good Relations”
Authors: Nunan Timothy 
Published: January 2022

Abstract
This article sheds new light on the end of the Cold War and the fate of anti-imperialism in the twentieth century by exploring how the Soviet Union and the Islamic Republic of Iran achieved a rapprochement in the late 1980s. Both the USSR and Iran had invested significant resources into presenting themselves as the leaders of the anti-imperialist movement and “the global movement of Islam,” and both the Soviet and Iranian governments sought to export their models of anti-imperialist postcolonial statehood to Afghanistan. However, by the mid-1980s both the Soviet Union and revolutionary Iran were forced to confront the limits to their anti-imperialist projects amid the increasing pull of globalization. Elites in both countries responded to these challenges by walking back their commitments from world revolution and agreeing to maintain the Najibullah regime in Afghanistan as a bulwark against Islamist forces hostile to Marxism-Leninism and Iran's brand of Islamic revolution. This joint pragmatic turn, however, contributed to a drought in anti-imperialist politics throughout the Middle East, leaving the more radical voices of transnational actors as one of the only consistent champions of anti-imperialism. Drawing on new sources from the former Soviet Union and Eastern Europe, as well as sources from Iran, Afghanistan, and the “Afghan Arabs,” the article sheds empirical and analytical light on discussions of the fate of anti-imperialism in the twilight of the Cold War.
Making Peaceful Revolution Impossible
Authors: Friedman Max Paul , Ferreira Roberto García 
Published: January 2022

Abstract
President John F. Kennedy's Alliance for Progress was intended to forestall Communist revolutions by fostering political and economic reform in Latin America. But Kennedy undermined his own goals by thwarting democratic, leftwing leaders seeking to carry out the kind of “peaceful revolution” his own analysis told him was necessary. This article reveals the Kennedy administration's role in overthrowing the Guatemalan government in 1963—until now only hinted at or even denied in the existing literature—to prevent the return to power of the country's first democratically elected president, Juan José Arévalo Bermejo. New archival evidence from Chile, Cuba, Guatemala, Mexico, Uruguay, the United Kingdom, and the United States sheds light on the transnational networks that supported Arévalo's attempt to run for the presidency in 1963, as well as the covert efforts of U.S. and Guatemalan officials to prevent “the most popular man in Guatemala” from taking office—a neglected Cold War milestone in Latin America.
The Storage of Antecedent Precipitation and Air Temperature Signals in Soil Temperature over China
Authors: Song Yaoming , Huang Anning , Chen Haishan 
Published: January 2022

AbstractSoil temperature (ST) is one of the key variables in land-atmosphere interactions. The response of ST to atmospheric changes and subsequent influence of ST on atmosphere can be recognized as the processes of signals propagation. Understanding the storing and releasing of atmosphere signals in ST favors the improvement of climate prediction and weather forecast. However the current understanding of the lagging response of ST to atmospheric changes is very insufficient. The analysis based on observation shows that both the storage of air temperature signals in deep ST even after four months and the storage of precipitation signals in shallow ST after one month are widespread phenomena in China. Air temperature signals at 2m can propagate to the soil depths of 160 cm and 320 cm after 1 month and 2 months, respectively. The storage of antecedent air temperature and precipitation signals in ST is slightly weaker and stronger during April to September, respectively, which is related to more precipitation during growing season. The precipitation signals in ST rapidly weaken after 2 months. Moreover, the effects of accumulated precipitation and air temperature on the signal storage in ST have significant monthly variations and vary linearly with soil depth and latitude. The storage of antecedent air temperature or precipitation signals in ST exhibits an obvious decadal variation with a period of more than 50 years, and it may be resulted from the modulation of the global climate patterns which largely affect local air temperature and precipitation.
Family involvement in advance care planning for people living with advanced cancer: A systematic mixed-methods review
Authors: Kishino Megumi , Ellis-Smith Clare , Afolabi Oladayo , Koffman Jonathan 
Published: January 2022

Background: Advance care planning is important for people with advanced cancer. Family involvement in advance care planning may be instrumental to achieving goal-concordant care since they frequently become surrogate decision-makers. Aim: To examine components, contexts, effects and linkages with intended outcomes of involving family members in advance care planning. Design: A mixed-methods systematic review, in which quantitative and qualitative data were extracted and synthesised using thematic synthesis leading to a logic model. Prospectively registered on PROSPERO (CRD42020208143). Data sources: Primary quantitative and qualitative research regarding family-involved advance care planning for people with advanced cancer were identified using Medline, Embase, PsycINFO and CINAHL from inception to September 2020. Quality appraisal was performed with ‘QualSyst’. Results: Fourteen articles were included. The synthesis identified perceptions of individuals and family members concerning family involvement in advance care planning and presents components for family-integrated advance care planning intervention. The logic model includes (i) addressing family members’ concerns and emotions and (ii) facilitating communication between individuals and family members which are distinctive when healthcare professionals engage with individuals as well as family members. Conclusions: This review provides a comprehensive understanding of family involvement in advance care planning and could inform its assessment and implementation in clinical practice. The number of included articles was limited. Therefore future research must focus on family integration and exploration of stakeholders’ perceptions to identify additional components and linkages between them within family-integrated advance care planning.
Measurement of antibody levels in patients with COVID-19 over time by immunofluorescence assay: a longitudinal observational study
Authors: Uysal Betul Borku , Yavuzer Serap , Islamoglu Mehmet Sami , Cengiz Mahir 
Published: January 2022

Background During the coronavirus disease 2019 (COVID-19) pandemic, antibody screening is a critical tool to assess anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. We examined variation in antibody titers associated with age and sex among patients with confirmed COVID-19. Methods Blood IgG levels were tested in 1081 patients with positive SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (RT-qPCR) tests between 1 September and 31 December 2020. Patients who did not experience reinfection were identified. Serum IgG levels were measured by immunofluorescence assay. Antibody positivity and antibody titers were analyzed according to time since infection, sex, and age. Results The mean (standard deviation) age was 41.2 (14.2) years and 41.2% of patients were women. The lowest antibody positivity rate between the first and ninth month post-infection was detected in the sixth month. The lowest antibody titers among patients aged 20 to 80 years occurred in those aged 30 to 39 years. The IgG titer was positively correlated with age in years (r = 0.125) and decades (r = 0.126). Conclusions Six months after infection, anti-SARS-CoV-2 antibody titers increased. Anti-SARS-CoV-2 antibody titers also increased with age. Immunity and pathogenicity should be investigated in addition to antibody positivity rates and antibody titers.