bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS BREAK EVEN POINT SEBAGAI PERENCANAAN LABA PADA UD. SILVIA FOOD
Authors: Nadhiroh Anisatun , M. Nur Kurniawan , Wiji Utami Sari 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui titik impas dan perencanaan laba di UD. Silvia Food. Teknik pengumpulan data dengan menggunakan data primer yang diperoleh dari hasil wawancara langsung kepada responden yang bersangkutan. Analisis data menggunakan break even point (BEP) dan margin kongtribusi. Hasil penelitian diketahui bahwa titik impas tahun 2018 sebesar Rp. 23.632.020 untuk kemasan 250 gram dan Rp. 21.948.102 untuk kemasan 500 gram. Titik impas tahun 2019 yaitu sebesar Rp. 27.310.494 untuk kemasan 250 gram dan Rp. 25.359.642 untuk kemasan 500 gram. Titik impas tahun 2020 yaitu Rp. 32.227.736 untuk kemasan 250 gram dan Rp. 29.307.138 untuk kemasan 500. Perusahaan merencanaan laba tahun 2021 sebesar 15% dari tahun 2020 yaitu perusahaan harus dapat melakukan penjualan sebesar Rp. 99.447.216 untuk kemasan 250 gram dan Rp. 187.500.518 untuk kemasan 500 gram. Untuk tahun 2022 perusahaan merencanakan laba sebesar 25%, untuk itu perusahaan harus dapat melakukan penjualan sebesar Rp. 131.090.032 untuk kemasan 250 gram dan Rp. 251.092.747 untuk kemasan 500 gram.
Rancang Bangun Fitur Chatbot Pada Website Politeknik Masamy Internasional
Authors: Pratiwi Inggrid Yanuar Risca , Ikhwan Yahdi , Rahman Rifki Zainur 
Published: October 2022

Website menyajikan informasi yang dapat terpublikasi dan menjadi konsumsi masyarakat sehingga masyarakat dapat memperoleh informasi lebih cepat dan informatif. Berkembangnya teknologi muncul berbagai kemudahan pengguna dalam memperoleh informasi lebih cepat melalui Chatbot. Pengujung website kampus Politeknik Masamy Internasional (POLMAIN) dapat membaca informasi pada masing-masing halaman website. Informasi yang disajikan pada website dirasa kurang lengkap dan informatif dalam mencari data atau informasi karena tidak memiliki fasilitas pencarian sehingga pengunjung harus membaca informasi satu per satu pada halaman website hingga pengunjung website mendapatkan informasi yang dibutuhkan. Permasalahan yang dihadapi adalah semakin hari jumlah pengguna yang ingin mengajukan pertanyaan dalam waktu bersamaan semakin banyak dan membutuhkan respon dengan cepat sehingga perancangan fitur chatbot ini diharapkan dapat membantu dalam mengatasi permasalahan tersebut untuk mempercepat pengguna mendapatkan informasi tentang kampus POLMAIN serta agar website kampus POLMIN lebih interaktif karena dapat melakukan tanya jawab untuk memberikan informasi. Chatbot pada website kampus POLMAIN ini dibangun menggunakan platform Eva.id.
Perancangan fitur chatbot website kampus POLMAIN ini memiliki beberapa tahap yaitu identifikasi masalah, identifikasi dataset melalui survei pertanyaan, pengumpulan data, membuat dataset, identifikasi spesifikasi perangkat kersa dan perangkat lunak, perancangan chatbot, implementasi chatbot dan ujicoba. Hasil survei pertanyaan dijadikan sebagai dataset knowledge base pertanyaan pada chatbot. Platform Eva.id membantu pembuatan fitur chatbot ini dimana penulis memasukkan dataset kedalam fitur knowledge based pada platform Eva.id. Knowledge based telah terbentuk, selanjutnya adalah tahap pengintegrasian chatbot ke website kampus POLMAIN dilakukan dengan menyalin script web widget dengan bahasa javascript di fitur channel dari platform Eva.id, selanjutnya script tersebut ditambahkan dalam script tampilan website POLMAIN.
Fitur chatbot ini memiliki dua(2) hak akses yaitu admin dan pengguna. Admin dapat mengelola pertanyaan, jawaban, keyword dan live chat. Pengguna dapat bertanya melalui bot atau melalui live chat dan menerima jawaban pertanyaan. Fitur chatbot pada website POLMAIN ini dapat membuat fungsi website sebagai pusat informasi yang lebih dinamis dan realtime tanpa harus membuka platform lain seperti aplikasi chatting Whatsapp karena memiliki fasilitas live chat sehingga lebih efisien dan mudah digunakan.
Deepfake attack prevention using steganography GANs
Authors: Noreen Iram , Muneer Muhammad Shahid , Gillani Saira 
Published: October 2022

Background
Deepfakes are fake images or videos generated by deep learning algorithms. Ongoing progress in deep learning techniques like auto-encoders and generative adversarial networks (GANs) is approaching a level that makes deepfake detection ideally impossible. A deepfake is created by swapping videos, images, or audio with the target, consequently raising digital media threats over the internet. Much work has been done to detect deepfake videos through feature detection using a convolutional neural network (CNN), recurrent neural network (RNN), and spatiotemporal CNN. However, these techniques are not effective in the future due to continuous improvements in GANs. Style GANs can create fake videos with high accuracy that cannot be easily detected. Hence, deepfake prevention is the need of the hour rather than just mere detection.

Methods
Recently, blockchain-based ownership methods, image tags, and watermarks in video frames have been used to prevent deepfake. However, this process is not fully functional. An image frame could be faked by copying watermarks and reusing them to create a deepfake. In this research, an enhanced modified version of the steganography technique RivaGAN is used to address the issue. The proposed approach encodes watermarks into features of the video frames by training an “attention model” with the ReLU activation function to achieve a fast learning rate.

Results
The proposed attention-generating approach has been validated with multiple activation functions and learning rates. It achieved 99.7% accuracy in embedding watermarks into the frames of the video. After generating the attention model, the generative adversarial network has trained using DeepFaceLab 2.0 and has tested the prevention of deepfake attacks using watermark embedded videos comprising 8,074 frames from different benchmark datasets. The proposed approach has acquired a 100% success rate in preventing deepfake attacks. Our code is available at https://github.com/shahidmuneer/deepfakes-watermarking-technique.
Effects of different fertilizers on nutrient quality and mineral elements in different economic forage groups in Qilian Mountain alpine meadows
Authors: Chen Xin , Jiao Ting , Nie Zhongnan , Zhang Degang , Wang Juan , Qi Juan 
Published: October 2022

The objective of this study was to examine the responses of nutrient quality and mineral elements of forages in different economic groups forages in the Qilian Mountains alpine meadows to different fertilization treatments. Eight fertilization treatments, potassium (K), nitrogen (N), zinc (Z), boric (B), copper (Cu), phosphorus (P), molybdenum (Mo), and selenium (Se), were sprayed onto forage roots, and no fertilizer was applied as a blank control (CK), with four replicates in each group. The forage trace element contents and nutritional quality of each economic group in to different treatments were determined in mid-August, and the trace element surplus and deficiency were analyzed. Compared with that in the control, the forage crude protein (CP) content in different economic groups under different fertilization treatments increased and fluctuated within the range of 7.7%–23.94%. The dry matter digestibility (DMD) ranged from 38.78% to 77.34% and showed no significant differences in DMD among treatments (P > 0.05). The DMD of legume forages was significantly higher than those of Gramineae grasses and sedges; there were no significant differences in forage acid detergent fiber (ADF) between any treatments and the control (P > 0.05), but ADF showed a decreasing trend in the treatments compared with that in the control. The P content increased by 81.81% in legumes (P < 0.05); however, it decreased by 38.46% and 61.29% in wilted grass and forbs (P < 0.05) and increased in Gramineae grasses and legumes under N treatment by 92.86% and 50% (P < 0.05), respectively. The Cu content under Cu, N, Zn, B and Se treatments increased significantly by 33.81%∼346.49% compared with that in the control. There were no significant differences in Zn content among the economic groups under different treatments (P > 0.05), but legumes showed better absorption of Zn. Consequently, the forages in this study were evaluated as having medium Cu (8.1–20 mg/kg), medium Se (0.11–1.0 mg/kg), and medium (30.1–60 mg/kg) to high (60.1–100 mg/kg) Zn contents. Comprehensive analysis showed that the application of different fertilizers could increase the CP and DMD of various forages, reduce ADF, and effectively improve the nutritional quality of pastures. The contents of N, Cu, Zn, and Se in forages increased under all treatments, and the contents of all forage elements were at appropriate levels. Applying K, N, P, Cu and Mo is beneficial to dominant species in Qilian Mountains alpine meadows.
Perception of nursing managers about technovigilance in the light of patient safety / Percepção dos gestores de enfermagem sobre a tecnovigilância à luz da segurança do paciente.
Authors: Santos Dutra Carla Rayane , De Queiroz Lima Luan José , Pereira de Oliveira Millena Rebeca , Tavares Galvão de Pontes. Carla Sandyele , Dos Santos Gabriela Fernanda , Lopes Oliveira Diego Augusto 
Published: October 2022

Objetivo: descrever a percepção de enfermeiros envolvidos na gestão de enfermagem sobre a tecnovigilância à luz da segurança do paciente. Método: estudo descritivo, com abordagem qualitativa, realizada com enfermeiros gestores lotados em um hospital referência em trauma de Pernambuco. Os dados foram coletados por meio de entrevista semi estruturada de abril à maio de 2020 e analisados por meio da técnica de análise de conteúdos de Bardin. Resultado: a análise levou ao surgimento de duas categorias temáticas: “Ações de cuidado com o equipamento e sua relação no cuidar do paciente” e “Uso e manuseio de equipamentos pela equipe de enfermagem e suas consequências na segurança do paciente”. Conclusão: evidenciou-se que os gestores demonstram entendimento acerca da importância do desenvolvimento de ações voltadas a tecnovigilância, como também de sua influência frente à equipe de enfermagem na promoção de uma assistência mais segura e de qualidade nas instituições de saúde.
Association Between Pretransplant Dialysis Modality and Kidney Transplant Outcomes
Authors: Ngamvichchukorn Tanun , Ruengorn Chidchanok , Noppakun Kajohnsak , Thavorn Kednapa , Hutton Brian , Sood Manish M. , Knoll Greg A. , Nochaiwong Surapon 
Published: October 2022

ImportanceThe benefits and disadvantages of different pretransplant dialysis modalities and their posttransplant outcomes remain unclear in contemporary kidney transplant care.ObjectiveTo summarize the available evidence of the association of different pretransplant dialysis modalities, including hemodialysis and peritoneal dialysis (PD), with posttransplant outcomes.Data SourcesMEDLINE, Embase, PubMed, Cochrane Library, Scopus, CINAHL, and gray literature were searched from inception to March 18, 2022 (updated to April 1, 2022), for relevant studies and with no language restrictions.Study SelectionRandomized clinical trials and nonrandomized observational (case-control and cohort) studies that investigated the association between pretransplant dialysis modality and posttransplant outcomes regardless of age or donor sources (living or deceased) were abstracted independently by 2 reviewers.Data Extraction and SynthesisFollowing Preferred Reporting Items for Systematic Reviews and Meta-analyses and Meta-analysis of Observational Studies in Epidemiology reporting guidelines, 2 reviewers independently extracted relevant information using a standardized approach. Random-effects meta-analysis was used to estimate pooled adjusted hazard ratio (HR) or odds ratio and 95% CI.Main Outcomes and MeasuresPrimary outcomes included all-cause mortality, overall graft failure, death-censored graft failure, and delayed graft function. Secondary outcomes included acute rejection, graft vessel thrombosis, oliguria, de novo heart failure, and new-onset diabetes after transplant.ResultsThe study analyzed 26 nonrandomized studies (1 case-control and 25 cohort), including 269 715 patients (mean recipient age range, 14.5-67.0 years; reported proportions of female individuals, 29.4%-66.9%) whose outcomes associated with pretransplant hemodialysis vs pretransplant PD were compared. No significant difference, with very low certainty of evidence, was observed between pretransplant PD and all-cause mortality (13 studies; n = 221 815; HR, 0.92 [95% CI, 0.84-1.01]; P = .08) as well as death-censored graft failure (5 studies; n = 96 439; HR, 0.98 [95% CI, 0.85-1.14]; P = .81). However, pretransplant PD was associated with a lower risk for overall graft failure (10 studies; n = 209 287; HR, 0.96 [95% CI, 0.92-0.99]; P = .02; very low certainty of evidence) and delayed graft function (6 studies; n = 47 118; odds ratio, 0.73 [95% CI, 0.70-0.76]; P &amp;lt; .001; low certainty of evidence). Secondary outcomes were inconclusive due to few studies with available data.Conclusions and RelevanceResults of the study suggest that pretransplant PD is a preferred dialysis modality option during the transition to kidney transplant. Future studies are warranted to address shared decision-making between health care professionals, patients, and caregivers as well as patient preferences.
Identification of Symptom Phenotypes of Hand Osteoarthritis Using Hierarchical Clustering: Results From the DIGICOD Cohort
Authors: Binvignat Marie , Pires Gabriel , Tchitchek Nicolas , Costantino Félicie , Courties Alice , Klatzmann David , Butte Atul J. , Combe Bernard , Dougados Maxime , Richette Pascal , Mariotti‐Ferrandiz Encarnita , Berenbaum Francis , Sellam Jérémie 
Published: October 2022

ObjectiveWe aimed to delineate phenotypes in hand osteoarthritis (HOA) based on cardinal symptoms (pain, functional limitation, stiffness, and aesthetic discomfort).MethodsWith data from the Digital Cohort Design (DIGICOD), we performed a hierarchical agglomerative clustering analysis based on Australian/Canadian Osteoarthritis Hand Index (AUSCAN) subscores for pain, physical function, stiffness, and visual analog scale for aesthetic discomfort. Kruskal‐Wallis and post hoc analyses were used to assess differences between clusters.ResultsAmong 389 patients, we identified 5 clusters: cluster 1 (n = 88) and cluster 2 (n = 91) featured low and mild symptoms; cluster 3 (n = 80) featured isolated aesthetic discomfort; cluster 4 (n = 42) featured a high level of pain, stiffness, and functional limitation; and cluster 5 (n = 88) had the same features as cluster 4 but with high aesthetic discomfort. For clusters 4 and 5, AUSCAN pain score was >41 of 100, representing only one‐third of our patients. Aesthetic discomfort (clusters 3 and 5) was significantly associated with erosive HOA and a higher number of nodes. The highly symptomatic cluster 5 was associated but not significantly with metabolic syndrome, and body mass index and C‐reactive protein level did not differ among clusters. Symptom intensity was significantly associated with joint destruction as well as with physical and psychological burden. Patients’ main expectations differed among clusters, and function improvement was the most frequent expectation overall.ConclusionThe identification of distinct clinical clusters based on HOA cardinal symptoms suggests previously undescribed subtypes of this condition, warranting further study of biological characteristics of such clusters, and opening a path toward phenotype‐based personalized medicine in HOA.
Composition‐Controllable Syntheses and Property Modulations from 2D Ferromagnetic Fe5Se8 to Metallic Fe3Se4 Nanosheets
Authors: Huan Yahuan , Luo Tiantian , Han Xiaocang , Ge Jun , Cui Fangfang , Zhu Lijie , Hu Jingyi , Zheng Feipeng , Zhao Xiaoxu , Wang Lili , Wang Jian , Zhang Yanfeng 
Published: October 2022

AbstractExploring new‐type 2D magnetic materials with high magnetic transition temperature and robust air stability has attracted wide attention for developing innovative spintronic devices. Recently, intercalation of native metal atoms into the van der Waals gaps of 2D layered transition metal dichalcogenides (TMDs) has been developed to form 2D non‐layered magnetic TMDs, while only succeeded in limited systems (e.g., Cr2S3, Cr5Te8). Herein, composition‐controllable syntheses of 2D non‐layered iron selenide nanosheets (25% Fe‐intercalated triclinic Fe5Se8 and 50% Fe‐intercalated monoclinic Fe3Se4) are firstly reported, via a robust chemical vapor deposition strategy. Specifically, the 2D Fe5Se8 exhibits intrinsic room‐temperature ferromagnetic property, which is explained by the change of electron spin states from layered 1T'‐FeSe2 to non‐layered Fe‐intercalated Fe5Se8 based on density functional theory calculations. In contrast, the ultrathin Fe3Se4 presents novel metallic features comparable with that of metallic TMDs. This work hereby sheds light on the composition‐controllable synthesis and fundamental property exploration of 2D self‐intercalation induced novel TMDs compounds, by propelling their application explorations in nanoelectronics and spintronics‐related fields.
The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca2+‐LRMDA Axis in Myeloid Cells
Authors: Guo Yu‐Yao , Gao Yue , Hu Yu‐Ru , Zhao Yuhan , Jiang Dexiang , Wang Yulin , Zhang Youjing , Gan Hu , Xie Chang , Liu Zheng , Zhong Bo , Zhang Zhi‐Dong , Yao Jing 
Published: October 2022

AbstractThe transient receptor potential vanilloid 2 (TRPV2) channel is a nonselective cation channel that has been implicated in multiple sensory processes in the nervous system. Here, it is shown that TRPV2 in myeloid cells facilitates virus penetration by promoting the tension and mobility of cell membrane through the Ca2+‐LRMDA axis. Knockout of TRPV2 in myeloid cells or inhibition of TRPV2 channel activity suppresses viral infection and protects mice from herpes simplex virus 1 (HSV‐1) and vesicular stomatitis virus (VSV) infection. Reconstitution of TRPV2 but not the Ca2+‐impermeable mutant TRPV2E572Q into LyZ2‐Cre;Trpv2fl/fl bone marrow‐derived dendritic cells (BMDCs) restores viral infection. Mechanistically, knockout of TRPV2 in myeloid cells inhibits the tension and mobility of cell membrane and the penetration of viruses, which is restored by reconstitution of TRPV2 but not TRPV2E572Q. In addition, knockout of TRPV2 leads to downregulation of Lrmda in BMDCs and BMDMs, and knockdown of Lrmda significantly downregulates the mobility and tension of cell membrane and inhibits viral infections in Trpv2fl/fl but not LyZ2‐Cre;Trpv2fl/fl BMDCs. Consistently, complement of LRMDA into LyZ2‐Cre;Trpv2fl/fl BMDCs partially restores the tension and mobility of cell membrane and promotes viral penetration and infection. These findings characterize a previously unknown function of myeloid TRPV2 in facilitating viral infection though the Ca2+‐LRMDA axis.
Ein Verbundmittel zur richtungsunabhängigen Schubkraftübertragung in HBV‐Decken
Authors: Sorg Christian , Kurz Wolfgang , d'Escurac Arnaud Pavis 
Published: October 2022

AbstractHolz‐Beton‐Verbunddecken (HBV‐Decken) werden in aktueller Baupraxis als einachsig spannende Tragsysteme, bei denen Kerven oder andere Verbinder zur Schubkraftübertragung eingesetzt werden, geplant und realisiert. Um die Vorteile des Holz‐Beton‐Verbundbaus mit den Vorteilen einer zweiachsig spannenden Flachdecke in Stahlbetonbauweise zu kombinieren, wird an der TU Kaiserslautern (TUK) zusammen mit dem Ingenieurbüro Werner Sobek Frankfurt GmbH & Co. KG (WS Frankfurt) im Rahmen eines gemeinsamen Forschungsprojekts eine flächige HBV‐Plattendecke mit biaxialer Tragwirkung entwickelt. Die Entwicklung eines Verbundmittels zur richtungsunabhängigen Schubkraftübertragung stellt dabei einen wichtigen Teilaspekt dar. Im Rahmen dieses Aufsatzes werden die Ergebnisse numerischer und experimenteller Untersuchungen des Verbundmittels (zylindrische Betonnocke) dargestellt und diskutiert. Hierbei stehen besonders die Steifigkeit und Tragfähigkeit im Vordergrund.
Fluidic integrated 3D bioprinting system to sustain cell viability towards larynx fabrication
Authors: Park Hae Sang , Lee Ji Seung , Kim Chang‐Beom , Lee Kwang‐Ho , Hong In‐Sun , Jung Harry , Lee Hanna , Lee Young Jin , Ajiteru Olatunji , Sultan Md Tipu , Lee Ok Joo , Kim Soon Hee , Park Chan Hum 
Published: October 2022

AbstractHerein, we report the first study to create a three‐dimensional (3D) bioprinted artificial larynx for whole‐laryngeal replacement. Our 3D bio‐printed larynx was generated using extrusion‐based 3D bioprinter with rabbit's chondrocyte‐laden gelatin methacryloyl (GelMA)/glycidyl‐methacrylated hyaluronic acid (GMHA) hybrid bioink. We used a polycaprolactone (PCL) outer framework incorporated with pores to achieve the structural strength of printed constructs, as well as to provide a suitable microenvironment to support printed cells. Notably, we established a novel fluidics supply (FS) system that simultaneously supplies basal medium together with a 3D bioprinting process, thereby improving cell survival during the printing process. Our results showed that the FS system enhanced post‐printing cell viability, which enabled the generation of a large‐scale cell‐laden artificial laryngeal framework. Additionally, the incorporation of the PCL outer framework with pores and inner hydrogel provides structural stability and sufficient nutrient/oxygen transport. An animal study confirmed that the transplanted 3D bio‐larynx successfully maintained the airway. With further development, our new strategy holds great potential for fabricating human‐scale larynxes with in vivo‐like biological functions for laryngectomy patients.
The impact of sarcopenia on survival and treatment tolerance in patients with head and neck cancer treated with chemoradiotherapy
Authors: Bentahila Rita , Giraud Philippe , Decazes Pierre , Kreps Sarah , Nay Paula , Chatain Augustin , Fabiano Emmanuelle , Durdux Catherine 
Published: October 2022

AbstractBackgroundSarcopenia appears to be a negative prognostic factor for poor survival outcomes and worse treatment tolerance in patients with head‐and‐neck squamous cell carcinoma (HNSCC). We evaluated sarcopenia's impact on overall survival (OS), disease‐free survival (DFS) and chemo‐radiation tolerance in patients with head‐and‐neck cancer (HNC) treated with chemoradiotherapy (CRT) from a monocentric observational study.MethodsWe identified patients with HNC treated by CRT between 2009 and 2018 with pretreatment imaging using positron emission tomography–computed tomography scans (PET/CT). Sarcopenia was measured using the pretreatment PET/CT at the L3 vertebral body using previously published methods. Clinical variables were retrospectively retrieved.ResultsOf 216 patients identified, 54 patients (25.47%) met the criteria for sarcopenia. These patients had a lower mean body mass index before treatment (21.92 vs. 25.65 cm/m2, p < 0.001) and were more likely to have a history of smoking (88.89% vs. 71.52%, p = 0.01), alcohol use (55.56% vs. 38.61%, p = 0.03) and positive human papilloma virus status (67.74% vs. 41.75%, p = 0.011). At 3 years of follow‐up, OS and DFS were 75% and 70% versus 82% and 85% for sarcopenic and non‐sarcopenic patients, respectively (p = 0.1 and p = 0.00015). On multivariate analysis, sarcopenia appeared as a pejorative factor on DFS (hazard ratio 2.174, p = 0.0001) in the overall cohort. Sarcopenic patients did not require more chemotherapy and radiation‐treatment interruptions and did not suffer from more chemo‐induced and radiation‐induced grade 3–4 toxicities than their non‐sarcopenic counterparts.ConclusionSarcopenia in HNSCC patients is an independent adverse prognostic factor for DFS after definitive chemoradiotherapy.