bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of regular sport activities on stress level in sporting and non-sporting university students
Authors: Szmodis Márta , Zsákai Annamária , Blaskó Gergely , Fehér Piroska , Annár Dorina , Sziráki Zsófia , Almási Gábor , Kemper Han CG 
Published: June 2022

Abstract

Background
Regular sport has favourable influence on the physical and mental state. Our aim was to analyse the relationship between regular sport activities, body parameters, cortisol level, perceived stress and the frequency of psychosomatic symptoms in male and female university students.

Methods
Subjects were university students (N = 200). They were divided in sporting (more than 7 h week−1: 56 males (sm), 50 females (sf)) and non-sporting (less than 3 h week−1: 44 males (nsm) and 50 females (nsf)) groups. Body composition was estimated by Inbody720-analyser. Stress levels were measured by (1) free cortisol level in saliva measured by using IBL-ELISA kits and (2) questionnaires about psychosomatic symptoms and perceived stress scale.

Results
There were significant subgroup’ differences in body composition (fat%:sm:12.1 ± 6.0 vs. nsm:17.9 ± 6.8; sf:20.8 ± 5.5 vs. nsf:25.4 ± 5.7; muscle%:sm:50.3 ± 3.6 vs. nsm:47.6 ± 3.9; sf:43.8 ± 3.2 vs. nsf:41.7 ± 3.3), and in stress level (total scores:sm:21.0 ± 5.7 vs. nsm:23.3 ± 7.2; sf:25.5 ± 7.0 vs. nsf:28.0 ± 9.7). There were gender differences in the psychosomatic symptoms' frequency (total scores: sm: 14.6 ± 6.3 vs. sf: 20.4 ± 7.4; nsm: 14.9 ± 6.1 vs. nsf: 19.6 ± 8.2). The sporting students had larger muscle, smaller fat percentages, and lower level of stress. Basic level of salivary cortisol revealed significant relation with physical activity: sporting students had lower level of cortisol. This relation was reflected in higher percentage of students with low level of cortisol in the physically active subgroups (s/ns males: 29% vs. 15%; s/ns females: 18% vs. 5%) and in the higher percentage of female students with high level of cortisol in the non-sporting subgroup (27% vs. 11%).

Conclusion
Regular sport activity is positively related with lower stress levels in university students.
Formation of research competence of future teacher educators based on the technology of project training
Authors: Mamytbayeva Zhanat , Kyakbayeva Ulbosyn , Azimbayeva Dariga , Kerimbayeva Rysty , Sarybekova Zhanat , Daurenbekov Kuanysh 
Published: June 2022

In this study, it is aimed to establish the research competence of future teacher educators based on the project education technology. The research was conducted in the spring semester of 2021–2022. The study with the participation of 328 university students was conducted in a quantitative research model. In the research, a 3-week project training technology and research competence training was provided to university students. In the study, a data collection tool developed by the researchers was used to collect data. The scale used in the study was delivered and collected by the online method of university students. The analysis of the data was carried out using the SPSS programme; frequency analysis was carried out using the t-test; and the results obtained were added to the study accompanied by tables. As a result of the research, it was found that the project training technology and research competence values of the groups of participants participating in the study had high values.
Keywords: Project education technology, teacher candidates, distance education, university students
Effect of Cementation Degree on Shear Characteristic and Failure Mechanism of Bimrocks Containing Gravels of Different Sizes
Authors: Hu Yanran , Sun Shaorui , Wei Jihong 
Published: June 2022

Abstract
To reveal the influence of cementation degree on the mechanical properties of bimrocks with different particle sizes under different types and contents of cement, indoor direct shear tests as well as numerical tests were conducted. The variation law of mechanical properties and the development law of internal force chain distribution of bimrocks under different conditions are fully studied. The specimens with three particle sizes, two cementing types (cement and gypsum), and three cementing contents were prepared for indoor shear tests under different normal stresses. The results show that the fluctuation of shear stress-displacement curve of bimrocks with round gravels of large particle size is relatively gentle, and the fluctuation of residual strength is relatively small. Under low normal stress, the peak shear strength of bimrocks with round gravels of large particle size can be increased by 115.2% under the action of cementation. Compared with the cohesion of samples without cementation, the maximum improvement of the cohesion of the samples containing large particle size, small particle size, and mixed particle size with different cementing materials is 143.2%, 149.0%, and 141.9%, respectively. The results show that, compared with the internal friction angle of samples without cementation, the maximum increases of the internal friction angle of the samples with large particle size, small particle size, and mixed particle size for adding different contents of cementing materials are 15.7%, 18.5%, and 21.2%, respectively. Numerical tests show that, with the increase of cementation degree, the gathering of force chain is more obvious and more concentrated near the shear surface.
Climate-Driven Changes in High-Intensity Wildfire on Orbital Timescales in Eurasia since 320 ka
Authors: Cheng Tianze , Zou Jianjun , Shi Xuefa , Gorbarenko Sergey , Vasilenko Yuriy , Bosin Alexandr , Liu Yanguang , Chen Bing 
Published: June 2022

Abstract
Wildfire is an integral part of the Earth’s climate system and plays an important role in shaping terrestrial ecosystems and biodiversity, atmospheric chemistry, regional climate, and the carbon cycle in the Earth’s history. However, the lack of high-resolution records of long wildfires limits our understanding of the natural variability, long-term trends of wildfire activity, and the reasons behind the changes in wildfire on orbital timescales. Here, a 320 ka long high-resolution wildfire record from the subarctic North Pacific is reconstructed with black carbon (BC), including its two subtypes char and soot. A 7-day-long back trajectory simulation analysis reveals the higher frequency of trajectories comes from Siberia. Our data show that continuous incidence of wildfire on a continental scale over the last 320 ka was higher during glacial periods than during the interglacial periods. The increase in wildfire frequency during glacial periods is ascribed to less precipitation. Contrasting patterns of wildfire incidence between marine isotope stages 2 and 6 may be ascribed to different fuel availability, which is related to contrasting configurations of the Northern Hemisphere ice sheet between glacial periods. A significant periodicity of 23 ka of our wildfire record suggests the precession of the Earth’s orbit pace wildfire development. The tight coupling of intensified wildfire and enhanced nutrient utilization efficiency suggests a nontrivial role of fire in the climate system.
Human liver microbiota modeling strategy at the early onset of fibrosis
Authors: Champion Camille , Neagoe Radu M. , Effernberger Maria , Sala Daniela T. , Servant Florence , Christensen Jeffrey E. , Arnoriaga-Rodriguez Maria , Amar Jacques , Lelouvier Benjamin , Loubieres Pascale , Azalbert Vincent , Minty Matthieu , Thomas Charlotte , Blasco-Baque Vincent , Gamboa Fabrice , Tilg Herbert , Cardellini Marina , Federici Massimo , Fernández-Real Jose-Manuel , Loubes Jean Michel , Burcelin Rémy 
Published: June 2022

Abstract
BackgroundGut microbiota is involved in the development of liver diseases such as fibrosis. We and others identified that selected sets of gut bacterial DNA and bacteria translocate to tissues, notably the liver, to establish a non-infectious tissue microbiota composed of microbial DNA and a low frequency live bacteria. However, the precise set of bacterial DNA, and thereby the corresponding taxa associated with the early stages of fibrosis need to be identified. Furthermore, to overcome the impact of different group size and patient origins we adapted innovative statistical approaches. Liver samples with low liver fibrosis scores (F0, F1, F2) to study the early stages of the disease were collected from Romania(n = 36), Austria(n = 10), Italy(n = 19), and Spain(n = 17). The 16S rRNA gene was sequenced. We considered the frequency, sparsity, unbalanced sample size between cohorts to identify taxonomic profiles and statistical differences.ResultsMultivariate analyses, including adapted spectral clustering with L1-penalty fair-discriminant strategies, and predicted metagenomics were used to identify that 50% of liver taxa associated with the early stage fibrosis were Enterobacteriaceae and Pseudomonadaceae. The Caulobacteraceae, Flavobacteriaceae and Propionibacteriaceae discriminated between F0 and F1. Predicted metagenomics analysis identified the preQ0 biosynthesis and pathways involving glucoryranose and glycogen degradation were negatively associated with liver fibrosis F1-F2 vs F0.ConclusionsWithout demonstrating causality, our results suggest first a role of bacterial translocation to the liver in the progression of fibrosis, notably at the earliest stages. Second, our statistical approach can identify microbial signatures and overcome issues regarding sample size differences, the impact of environment, and sets of analyses.TirguMECCH ROLIVER Prospective Cohort for the Identification of Liver Microbiota, registration 4065/2014. Registered 01 01 2014
Detection of SARS-CoV-2 in Saliva using the BinaxNOW™ COVID-19 Antigen Self Test
Authors: Chomczynski Peter Wladyslaw , Vires Kianna M , Rymaszewski Michal , Heiny Judith Ann , Chomczynski Piotr 
Published: June 2022

Abstract
We conducted a pilot study to determine if the BinaxNOW rapid antigen test can detect SARS-CoV-2 antigen in saliva, in place of the specified nasal (Nares) swab sample. A nasal swab may not provide an optimal sample for detecting Omicron, now the predominant variant, because Omicron sheds a greater viral load into saliva than into the nasal passages. Saliva was obtained from non-infected donors, spiked with varying concentrations of heat-denatured SARS-CoV-2 virus, and tested using the BinaxNOW kit following the manufacturer’s instructions. The BinaxNOW test detected COVID-19 in saliva samples with a Limit of Detection (LOD) of 178 TCID50/mL saliva, which was the lowest concentration tested. This detection sensitivity is comparable to the LOD reported by the manufacturer for BinaxNOW (140.6 TCID50/mL) using nasal samples. This result shows that the BinaxNOW test can detect SARS-CoV-2 in saliva with a detection power comparable to that obtained using nasal swab samples.
Theoretical and Experimental Research on Active Suspension System with Time-delay Control
Authors: Wu Kaiwei , Ren Chanbo , Li Lin , Sun Zehao 
Published: June 2022

Abstract
Time delay has a great impact on the performance of the control system, and even leads to the unexpected instability of the feedback control system. Aiming at the adverse effect of time delay on the control effect and stability of active suspension system, this paper proposes to suppress the complex dynamic behavior of vehicle by applying time-delay displacement feedback. In this paper, the time-delay feedback control characteristics of the system are studied by combining theory with experiment. Firstly, the dynamic equation of suspension system with time-delay is established, the system stability is analyzed by frequency domain scanning method, the simulation model is established, and the superiority of time-delay feedback control under external excitation is verified by comparing harmonic excitation with passive control and backstepping control. Finally, the 1/4 model bench test of the active suspension system is carried out, and the comparison between the simulation results and the test results under the same working conditions shows that the two have good consistency. The results show that the research is credible, and the research results can provide reference for the actual design and application of active/semi-active vehicle suspension controllers.
Introducing field evaporation energy loss spectroscopy
Authors: ROUSSEAU Loïc , Normand Antoine , Morgado Felipe F. , Soreide Hanne S. , Stephenson Leigh , Hatzoglou Constantinos , Costa Gérald Da , Tehrani Kambiz , Freysoldt Christoph , Gault Baptiste , Vurpillot François 
Published: June 2022

Abstract
Identifying the chemical and bonding state of all atoms in a material in three-dimensions remains an unresolved issue. Here, we demonstrate that this information was always intrinsically present within atom probe tomography experimental data, but until now it was overlooked or consciously suppressed. Using an analytical model and robust simulations, we show that the mass peak shape contains information on the ion’s energy loss related to how the atom was bound to the surface, and its neighbourhood. We introduce a complete data processing approach, termed field evaporation energy loss spectroscopy (FEELS), that retrieves and maps variations of the chemical state in 3D with nanometric resolution. We showcase the application of FEELS by analyzing microstructural features and defects in an array of metallic materials. FEELS can be applied on any atom probe data set to more profoundly analyse a material’s characteristics.
Excessive crying in children with cerebral palsy and communication deficits - a fixed-sequence, crossover clinical trial
Authors: Potharaju Nagabhushana Rao 
Published: June 2022

Abstract
Aim: To study epidemiology, response to drug therapy, and a drug taper after 250 days of treatment of excessive crying in children with cerebral palsy with communication deficits (ECCCPCD). Methods: This was a fixed-sequence crossover study of 131 consecutive subjects <15 years with>7.5 hours crying duration/day for 30 straight days. Outcome measures were epidemiological data, measurement of means of total and unexplained ECCCPCD durations (TECCCPCCD and UECCCPCD) while on the placebo (M1), while on treatment (M2-M5), and the effect of a drug taper (M4). Results: 74% were <2 years; 65% were males. Paired t-tests between TECCCPCCD of M1-M2 yielded a mean difference of -3.67 (95% CI -3.80 to -3.53), p<0.001; between UECCCPCCD of M1-M2,-3.04 (95% CI -3.16 to -2.93), p<0.001. Wilcoxon tests between TECCCPCCD of M1-M5 yielded medians of 9.98 (95% CI 9.73 to 10.16) and 2.67 (95% CI 2.53 to 2.82), p<0.001. Wilcoxon tests between UECCCPCCD of M1-M5 yielded medians of 8.22 (95% CI 8.02 to 8.39) and 2.16 (95% CI 2.04 to 2.28), p<0.001. The dosage could be tapered in 51.15% of participants. Conclusions: Treatment of spasticity, dystonia, visceral, and neuropathic pain reduced crying. The drug requirement was less after 250 days of treatment.
The relationship between body composition and vital capacity index of medical students in Shenyang of China------A cross-sectional survey
Authors: Zhang Han , Sun Lu , Yu Ye , Xin Hong , Wu Li , Yang Feng Mei , Liu Jie , Zhang Zhuo 
Published: June 2022

Abstract
Objectives: This study aimed to examine the associations between body composition and vital capacity index (VCI) among medical students of Shenyang, China.Study design: The design of this study is a cross-sectional study.Methods: Participants were 2063 individuals (17~25 years) from a medical college in Shenyang, who participated in this survey from April to May 2017. Height, weight, fat mass (FM), fat free mass (FFM), protein mass (PM), total body water (TBW), mineral mass (MM), vital capacity were measured, then BMI and VCI were calculated. Stepwise multiple linear regression analysis was used to evaluate the effect of body composition on VCI of participants in different genders. In addition, subgroup analysis was carried out according to BMI levels.Results: Male students showed significantly higher height, weight, BMI, FFM, PM, TBW, MM, VC, and VCI, but lower FM in comparison with female students. Stepwise multiple linear regression analysis showed that in both sexes FM was negatively correlated with VCI which represents pulmonary function (r < 0; P = 0.000). After dividing the whole participants by BMI, further correlation analysis showed FM was positively correlated with VCI only for male subgroups with BMI < 18.5 (r > 0; P = 0.05). Conclusion: Overall, FM is highly negatively correlated with the VCI of Chinese medical students of both genders. However, FM has a potential role to improve the VCI of underweight male students.
Defective type I interferon immunity is associated with increasing COVID-19 severity
Authors: Duffy Darragh , SMITH Nikaïa , Possémé Céline , Bondet Vincent , Sugrue Jamie , Townsend Liam , Charbit Bruno , Rouilly Vincent , Saint-André Violaine , Dott Tom , Pozo Andre Rodriguez , Yatim Nader , Schwartz Olivier , Cervantes-Gonzales Minerva , Ghosn Jade , Bastard Paul , Casanova Jean-Laurent , Szwebel Tali-Anne , Terrier Benjamin , Conlon Niall , O'Farrelly Cliona , Cheallaigh Cliona Ni , Bourke Nollaig 
Published: June 2022

Abstract
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death. We previously reported that reduced blood type I interferon (IFN-I) in severe COVID-19 patients preceded clinical worsening. These results were supported by studies which identified genetic mutations in loci of the TLR3- or TLR7-dependent IFN-I pathways, or autoantibodies neutralizing IFNα or IFNω, as major risk factors for development of severe and critical COVID-19 pneumonia. Here, we analyzed a range of IFN-I associated responses in patient cohorts with different severities of COVID-19, showing that baseline plasma IFNα measures differed significantly according to the immunoassay used, as well as timing of sampling, the IFNα subtype measured, and the presence of autoantibodies. We then compared immune responses induced by ex vivo stimulation between non-hospitalized moderate cases (n=27) and hospitalized (n=17) adult patients that required oxygen supplementation. This showed a consistently reduced induction of IFN-I proteins in hospitalized COVID-19 patients upon stimulation, that was not associated with detectable neutralizing autoantibodies against IFNα or IFNω. We confirmed the poor induction of IFN-I in an independent patient cohort (n=33), and showed it was more pronounced with severe disease. Intracellular proteomic analysis showed that while monocyte numbers were increased in hospitalized COVID-19 patients, they did not secrete IFN-I in response to stimulation. This was further confirmed by ex vivo whole blood stimulation with IFN-I which induced a transcriptomic response associated with inflammation in hospitalized COVID-19 patients, that was not seen in controls or non-hospitalized moderate cases. These results may explain the dichotomy of the poor clinical response to IFN-I based treatments in late stage COVID-19, despite the critical importance of IFN-I in early acute infection. An improved understanding of such variable responses to treatment may help to identify potential alternative therapeutic strategies.
Ionospheric Error Correction and Image Enhancement for Spaceborne Ice-Sounding Radar
Authors: Li Yu , Wang Yong , Zhang Jun , Wen He , Li Caipin , Duan Chongdi 
Published: June 2022

Abstract
Current ice-sounding radars can be divided into two categories, i.e., vehicular platform and airborne platform. The former possesses high detection accuracy, but its disadvantage restricts the measurement in narrow coverage range. The latter could achieve wide observation range instead of precise positioning capability. While spaceborne ice-sounding radar has the advantages of sensitive timeliness, stable time series and high detection efficiency, which is of great significance for scientific research of the three polar regions. In this paper, a novel ionospheric error correction and image enhancement method for spaceborne ice-sounding radar has been presented. Firstly, theoretical echo model of spaceborne ice-sounding radar is established based on real measured ionospheric data, and the influence of background ionosphere on receiving signal with small bandwidth and low carrier frequency is quantitatively analyzed. On this basis, the universal ionospheric error correction objective function is derived to remove the ionosphere effect. Finally, the cartoon G-channel component of ice-sounding image can be extracted by employing the improved MCA (Morphological Component Analysis) model, and thus to enhance the regional contrast of subglacial lake and other background units. Experimental results based on real measured data verify the effectiveness of the proposed algorithm.
In-cavity pressure measurements for failure diagnosis in injection moulding process and correlation with Numerical Simulation
Authors: Araújo Cátia , Pereira Diogo , Dias Diana , Marques Rita , Cruz Sílvia 
Published: June 2022

Abstract
The pressure profile recognition technique for monitoring and diagnose processing failures during an injection moulding process, such as burn marks, and short shots, is a useful instrument for process and part quality control, production with zero defects and greater efficiency. Therefore, this work aims to demonstrate the feasibility of the in-cavity pressure monitorization for failure diagnose and injection moulding process optimization. The methodology used to analyse the obtained pressure variation is presented. The results were correlated to the theoretical profile curve, which enables to obtain information about the process and the moulding tool. This way, it was possible to determine the origin of the defects present in the injected parts, focusing not only on the velocity to pressure switchover, but also in the initial part of the curve, related to the filling phase. Moreover, the obtained measured results and the studied processing conditions were correlated with the injection moulding process simulation.
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis
Authors: Sun Zewei , Chen Wenjing , Wang Zhen , Wang Shuai , Zan Jie , Zhao Wenting 
Published: June 2022

Abstract

Background
Atherosclerosis, characterized as the chronic inflammation of the arterial wall, is one of the leading causes of coronary artery disease (CAD), and macrophages are found to play essential roles in the initiation and progression of inflammation in atherosclerosis. N6-methyladenosine (m6A) modification, as the most abundant epi-transcriptomic modification in mRNA, is found to mediate the atherogenic inflammatory cascades in vascular endothelium. The detailed molecular mechanism of m6A methylation regulating inflammatory response during atherosclerosis is still not fully known.
Results
In this study, we find oxidized low-density lipoprotein (oxLDL) stimulation increases methyltransferases Mettl3 and Mettl14 expressions in macrophages, whereas the total m6A modification level in macrophages decreases under oxLDL stimulation. Matrin-3 (Matr3), an RNA binding protein, is identified to function a suppressive role on oxLDL-mediated macrophage inflammatory responses through inhibiting activation of pro-inflammatory signaling, mitogen-activated protein kinase (MAPK) by m6A-mediated mRNA decay via regulating the formation of Mettl3-Mettl14 complex. Moreover, we find that Matr3 expression decreases in the oxLDL-stimulated macrophages, and the peripheral blood mononuclear cells from patients with CAD, and overexpression of Matr3 significantly alleviates atherosclerosis development in vivo.
Conclusion
Our study for the first time clarifies the role of Matr3 on macrophage inflammatory responses during atherosclerotic development, and supplies deep understanding on the relationship of m6A modification and inflammatory responses in atherosclerosis.