bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the efficacy of transcatheter arterial embolization combined with apatinib on rabbit VX2 liver tumors by intravoxel incoherent motion diffusion-weighted MR imaging
Authors: Chen Can , Liu Xiao , Deng Lingling , Liao Yunjie , Liu Sheng , Hu Pengzhi , Liang Qi 
Published: September 2022

Background and purposeIt is crucial to evaluate the efficacy, recurrence, and metastasis of liver tumors after clinical treatment. This study aimed to investigate the value of Introvoxel Incoherent Motion (IVIM) imaging in the evaluation of rabbit VX2 liver tumors treated with Transcatheter Arterial Embolization (TAE) combined with apatinib.MethodsTwenty rabbit VX2 liver tumor models were established and randomly divided into either the experimental group (n=15) or the control group (n=5). The experimental group was treated with TAE combined with oral apatinib after successful tumor inoculation, while no treatment was administered following inoculation in the control group. IVIM sequence scan was performed in the experimental group before treatment, at 7 and 14 days after treatment. All rabbits were sacrificed after the last scan of the experimental group. Marginal tissues from the tumors of both groups were excised for immunohistochemical analysis to observe and compare the expression of microvessel density (MVD). The alterations of IVIM-related parameters of tumor tissues in the experimental group, including Apparent Diffusion Coefficient (ADC), True Diffusion Coefficient (D), Pseudodiffusion Coefficient (D*), and Perfusion Fraction (f) were compared at different periods, and the correlation between these parameters and MVD was analyzed.ResultsAfter treatment, ADC and D values significantly increased, whereas D* and f values both decreased, with statistically significant differences.(P&lt;0.05). The average tumor MVD of the experimental group after TAE combined with apatinib ((33.750 ± 6.743) bars/high power field (HPF)) was significantly lower than that in the control group ((64.200 ± 10.164) bars/HPF)). Moreover, D and f were positively correlated with tumor MVD in the experimental group (r=0.741 for D and r=0.668 for f, P&lt;0.05). However, there was no significant correlation between ADC and D* values of the experimental group and tumor MVD (r=0.252 for ADC and r=0.198 for D*, P&gt;0.05).ConclusionIVIM imaging can be employed to evaluate the efficacy of TAE combined with apatinib in rabbit VX2 liver tumors. Alterations in D and f values were closely related to the MVD of liver tumor tissues.
Favorable outcome of high-dose chemotherapy and autologous hematopoietic stem cell transplantation in patients with nonmetastatic osteosarcoma and low-degree necrosis
Authors: Hong Kyung Taek , Park Hyun Jin , Kim Bo Kyung , An Hong Yul , Choi Jung Yoon , Cheon Jung-Eun , Park Sung-Hye , Kim Han-Soo , Kang Hyoung Jin 
Published: September 2022

BackgroundA low-degree tumor necrosis after neoadjuvant chemotherapy is a poor prognostic factor for osteosarcoma (OSA). However, the role of high-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation in OSA remains controversial. We analyzed the treatment outcomes and prognostic factors of nonmetastatic OSA and compared the HDC and conventional chemotherapy (CC) outcomes of patients with &lt;90% necrosis after neoadjuvant chemotherapy.MethodsWe retrospectively evaluated patients with OSA treated at the Seoul National University Children’s Hospital from 2000 to 2020. Totally, 113 patients with non-metastatic OSA at diagnosis were included. The majority were treated with cisplatin, doxorubicin, and methotrexate as neoadjuvant chemotherapy. This was continued when the postoperative necrosis rate was &gt;90% (good response [GR]), whereas most cases with &lt;90% (poor response [PR]) were changed to chemotherapy. The HDC regimen was composed of melphalan, etoposide, and carboplatin.ResultsThe median age at diagnosis was 12.6 years (range, 5.0–20.3), and 61.9% of patients were men. The 5-year event-free survival (EFS) and overall survival (OS) rates were 75.8% and 91.5%, respectively. Among these, 59 and 44 patients were included in the GR and PR groups, respectively. The GR group had a better 5-year EFS rate than the PR group (82.4% vs. 67.3%, p=0.071). Age at diagnosis, sex, tumor site, type of neoadjuvant chemotherapy, and degree of tumor necrosis were not different between the PR-HDC (n=24) and PR-CC (n=20) groups. The 5-year EFS and OS rates in the PR-HDC (n=24) and PR-CC (n=20) groups were 78.6% and 53.6% (p=0.065) and 100% and 76.9% (p=0.024), respectively. In the Cox regression analysis, the PR-CC group (hazard ratio, 4.95; p=0.004) and age ≥12 years (hazard ratio, 2.68; p=0.024) were significant risk factors for 5-year EFS.ConclusionsHDC showed favorable outcomes in patients with non-metastatic OSA and &lt;90% necrosis after neoadjuvant chemotherapy.
Activation of uroepithelial 5-HT4R inhibits mechanosensory activity of murine bladder afferent nerves
Authors: Lu Yu , Li Jie , Dong Li , Luo Ping , Zhang Guohua , Rong Weifang 
Published: September 2022

Serotonin (5-HT) is known to act via multiple 5-HT receptors at spinal and supraspinal levels to regulate micturition. However, the contribution of peripheral 5-HT and its receptors in bladder physiology and pathology is not very well understood, despite evidence showing expression of multiple 5-HT receptors in the bladder wall and 5-HT may activate bladder afferent nerves. The current study was designed to investigate the possible role of 5-HT4R in modulation of the sensitivity of bladder afferents to bladder filling. Immunofluorescent staining showed abundant 5-HT4R immunoreactivity largely confined to the uroepithelium in wild type (WT) but not 5-HT4R−/− mice. In the ex vivo bladder-pelvic nerve preparation, intravesical application of the 5-HT4R agonist RS67333 (1–30 μm) caused concentration-dependent decreases of the pelvic nerve response to bladder filling. Such effect was not observed in the presence of 5-HT4R antagonist GR125487 or in 5-HT4R−/− preparations. A cohort of 5-HT4R−/− and WT control mice were treated with intraperitoneal injections of cyclophosphamide (CYP) (75 mg/kg, three times at 2 days interval) to induce chronic cystitis. Void spot analysis showed that CYP-treated 5-HT4R−/− mice urinated more frequently than their CYP-treated WT counterparts. Concomitantly, bladder afferents of CYP-treated 5-HT4R−/− mice displayed exaggerated sensitivity to bladder filling in comparison with the CYP-treated WT controls. These data suggest that 5-HT4R expressed on uroepithelial cells plays an inhibitory role in mechanosensory transduction in the bladder. Loss of 5-HT4R-mediated inhibition may enhance bladder afferent sensitivity and exacerbate bladder overactivity in pathological conditions. We propose that 5-HT4R agonists might be exploited for the treatment of overactive and painful bladder symptoms.
Engaging faith communities in public health messaging in response to COVID-19: Lessons learnt from the pandemic in Ituri, Democratic Republic of Congo
Authors: Baba Amuda , Grant Liz , Pearson Nigel , Wild-Wood Emma , Falisse Jean-Benoit , Way Yossa , Kangamina Sadiki 
Published: September 2022

PurposeTo understand challenges faced by faith leaders in the Democratic Republic of Congo (DRC) in engaging with current public health strategies for the COVID-19 pandemic; to explain why long-standing collaborations between government, faith-based health services and leaders of faith communities had little impact; to identify novel approaches to develop effective messaging that resonates with local communities.MethodsA qualitative participatory research design, using a workshop methodology was deployed to seek opinions of an invited group of faith leaders in the DRC provinces of Ituri and Nord-Kivu. A topic guide was developed from data gathered in prior qualitative interviews of faith leaders and members. Topics were addressed at a small workshop discussion. Emerging themes were identified.FindingsLocal faith leaders described how misinterpretation and misinformation about COVID-19 and public health measures led to public confusion. Leaders described a lack of capacity to do what was being asked by government authorities with COVID-19 measures. Leaders' knowledge of faith communities' concerns was not sought. Leaders regretted having no training to formulate health messages. Faith leaders wanted to co-create public health messages with health officials for more effective health messaging.ConclusionPublic trust in faith leaders is crucial in health emergencies. The initial request by government authorities for faith leaders to deliver set health messages rather than co-develop and design messages appropriate for their congregations resulted in faith communities not understanding health messages. Delivering public health messages using language familiar to faith communities could help to ensure more effective public health communication and counter misinformation.
Non-occupational lead poisoning associated with traditional Chinese medicine: A case report
Authors: Ma Huan , Wu Li-meng , Zou Yu , Li Xiao-an 
Published: September 2022

IntroductionTraditional Chinese medicine has a long history and is widely popular in China because of its safety and small side effects. In Chinese families, people believe that the combination of traditional Chinese and Western medicine is more effective, and in terms of conditioning and health care, they tend to rely on traditional Chinese medicine. However, the toxic and side effects of traditional Chinese medicine, especially heavy metal poisoning, should not be ignored.Patient concernsA case of non-occupational lead poisoning caused by long-term use of traditional Chinese medicine.DiagnosisA 21-year-old man with severe colic periumbilical pain was referred to our hospital. Through careful inquiry of his medical history, we found that he had been taking traditional Chinese medicine to treat facial acne in the past year. His test results showed anemia, liver damage, blood lead concentration of 1,268.4 μg/L, and bone marrow smear showed basophilic stippling erythrocyte. The patient was diagnosed with “lead poisoning.”InterventionsThe patient was given treatment with lead driving.OutcomesThe patient recovered after treatment.ConclusionWe found that lead poisoning in patients taking traditional Chinese medicine has been reported from time to time. Through consulting the data, we summarized the most common drugs leading to lead poisoning, and reviewed the pathogenesis and common clinical manifestations of lead poisoning. Because lead poisoning is easy to be misdiagnosed, we should ask more carefully about the past history and drug history of patients in order to make timely diagnosis and treatment.
Markov Moment Problem and Sandwich Conditions on Bounded Linear Operators in Terms of Quadratic Forms
Authors: Olteanu Octav 
Published: September 2022

As is well-known, unlike the one-dimensional case, there exist nonnegative polynomials in several real variables that are not sums of squares. First, we briefly review a method of approximating any real-valued nonnegative continuous compactly supported function defined on a closed unbounded subset by dominating special polynomials that are sums of squares. This also works in several-dimensional cases. To perform this, a Hahn–Banach-type theorem (Kantorovich theorem on an extension of positive linear operators), a Haviland theorem, and the notion of a moment-determinate measure are applied. Second, completions and other results on solving full Markov moment problems in terms of quadratic forms are proposed based on polynomial approximation. The existence and uniqueness of the solution are discussed. Third, the characterization of the constraints T1≤T≤T2 for the linear operator T, only in terms of quadratic forms, is deduced. Here, T1, T,and T2 are bounded linear operators. Concrete spaces, operators, and functionals are involved in our corollaries or examples.
Analisis Kombinasi Metode Algoritma MFEP dan AHP Pada Pemilihan Bibit Unggul Kopi Robusta
Authors: Syaputra Asep 
Published: September 2022

Kota Pagar Alam sebagai daerah yang warganya mayoritas berprofesi petani. Komoditas yang paling banyak ditanam di wilayah ini adalah kopi dan sayuran. Oleh karena itu, daerah tersebut cocok untuk dijadikan sebagai daerah penelitian dan untuk melakukan penilaian dasar (baseline assessment) tanaman lokal, khususnya pertanian kopi Robusta. Penggunaan metode Multi-Factor Evaluation Process (MFEP) dan Analytical Hierarchy Process (AHP) sangat cocok jika diterapkan untuk penelitian sistem pendukung keputusan. Metode ini dipilih karena memungkinkan untuk memilih opsi terbaik dari berbagai opsi. Dalam hal ini, pilihan yang dimaksud adalah bibit yang cocok untuk ditanam oleh petani berdasarkan kriteria yang ditentukan. Penyelidikan dilakukan dengan menentukan nilai bobot untuk setiap atribut, dilanjutkan dengan proses komputasi untuk menentukan kriteria dan alternatif yang optimal, yaitu bibit unggul kopi robusta yang layak dibudidayakan. Dengan adanya penelitian ini yang mengimplementasikan kombinasi metode Multifactor Evaluation Process (MFEP) dan Analitycal Hierarchy Process (AHP) dan dengan perancangan berorientasi objek dengan menggunakan Unified Modeling Language (UML) akan memudahkan Dinas Pertanian Kota Pagar Alam dan petani kopi Robusta dalam memilih bibit kopi yang tepat untuk ditanam sehingga petani kopi dapat mencapai hasil yang memuaskan.
L’affirmation d’une réparation autonome de la « dévalorisation sociale » de la victime directe
Authors: Augier-Francia Émeline 
Published: September 2022

La deuxième chambre civile de la Cour de cassation réaffirme que la « dévalorisation sociale » de la victime directe est indemnisable à titre autonome par le biais de l’incidence professionnelle. Il ne fait donc plus aucun doute que la Haute juridiction reconnaît la part extrapatrimoniale de ce poste de préjudice, y compris pour les jeunes victimes qui ne pourront jamais exercer d’activité professionnelle du fait de leur handicap.
Effect of Blood Pressure Control on the Severity of COVID-19 Patients
Authors: Mangopo Nirwana E. , Wantania Frans E. , Umboh Octavianus R. H. 
Published: September 2022

Abstract: Hypertension is one of the chronic conditions that cause the most mortality worldwide. As a comorbid disease, it is often found in hospitalized patients with coronavirus disease 2019 (COVID-19). Uncontrolled blood pressure was found to be independently associated with a higher risk for more adverse clinical outcomes in COVID-19 patients. This study aimed to evaluate the effect of blood pressure control on the severity of COVID-19 sufferers. This was a literature review study using three databases, namely PubMed, ClinicalKey, and Google Scholar according to the inclusion and exclusion criteria of the study. The results obtained 10 articles. Most showed the effect of blood pressure control on the severity of COVID-19 sufferers. In conclusion, uncontrolled blood pressure in COVID-19 patients with hypertension during hospitalization has an effect on mortality.Keywords: blood pressure control; hypertension; COVID-19 Abstrak: Hipertensi merupakan salah satu kondisi kronis penyebab mortalitas terbanyak di dunia dan menjadi penyakit penyerta yang banyak ditemukan pada pasien rawat inap dengan Coronavirus Disease 2019 (COVID-19). Tekanan darah yang tidak terkontrol ditemukan secara independen terkait dengan risiko yang lebih tinggi untuk hasil klinis yang lebih merugikan pada pasien COVID-19. Penelitian ini bertujuan untuk mengevaluasi pengaruh kontrol tekanan darah terhadap tingkat keparahan penderita COVID-19. Jenis penelitian ialah literature review. Pencarian data menggunakan tiga database yaitu PubMed, ClinicalKey, dan Google Scholar sesuai dengan kriteria inklusi dan eksklusi penelitian. Hasil penelitian mendapatkan 10 artikel. Sebagian besar menunjukkan adanya pengaruh kontrol tekanan darah terhadap tingkat keparahan penderita COVID-19. Simpulan penelitian ini ialah tekanan darah yang tidak terkontrol pada pasien COVID-19 dengan hipertensi selama rawat inap di rumah sakit memiliki pengaruh terhadap mortalitas.Kata kunci: kontrol tekanan darah; hipertensi; COVID-19
Correlation between Right Ventricular Function with Revascularization Time and 30-day Mortality in ST-Elevation Myocardial Infarction Patients Underwent Right Coronary Artery Intervention
Authors: Luntungan Marshell , Djafar Dewi U. , Panda Agnes L. , Sarayar Agustinus M. , Yofrido Filipus M. 
Published: September 2022

Abstracts: Right ventricular (RV) function provides strong prognostic information in patients treated with primary percutaneous coronary intervention (PCI) due to myocardial infarction. Longitudinal RV systolic function can be assessed by the measurement of the tricuspid annular plane systolic excursion (TAPSE). This study aimed to evaluate the correlation between TAPSE and revascularization time with 30-day mortality using TIMI risk score in patients presenting STEMI who underwent revascularization of right coronary artery (RCA). This was a descriptive amd analytical study. Data were collected from iSTEMI Registry database which consisted of 49 STEMI patients undergoing PCI in RCA and TAPSE measurement at Prof. Dr. R. D. Kandou General Hospital from October 3rd, 2018 to July 28th, 2019. Echocardiographic examination was done within 48 hours of hospitalization. A descriptive analysis and bivariate correlation with Spearman’s rho were applied between given variables. P-value of <0.05 was considered to be statistically significant. The results showed that the mean age of the patients was 57.92 10.345 years old and 79.2% were male. The mean TAPSE measurement was 18.51 mm +/- 3.63 mm. The median revascularization time was 357.5 minutes while median TIMI score was 4. Shorter treatment time (p=0.708) and lower TIMI score (p=0.923) were not associated with better right ventricular function measured with TAPSE in patients undergoing RCA intervention. In conclusion, right ventricular function is not associated with revascularization time and thirty days mortality in patients presenting with ST-elevation acute myocardial infarction involving right coronary artery.Keywords: tricuspid annular plane systolic excursion; revascularization time; right coronary artery; ST-elevation myocardial infarction
Kajian Potensi Minyak Atsiri (Volatile Organic Compounds) Sebagai Salah Satu Pengendali Hama Tanaman
Authors: Gosal Lidyana , Hosang Meldy 
Published: September 2022

Excessive use of pesticides is harmful to health and the environment. One way that can be used in pests environmentally friendly control is by using essential oils. Essential oils are obtained by extracting various botanical sources. Essential oils can be extracted using a variety of methods. One of them is the distillation method, by separating water vapor and oil. One of the essential oil that could be used for pest control is Volatile Organic Compounds (VOCs). In several studies, essential oils have been tested to act as a repelen, fumigant and Atraktant against pests so that essential oil compounds can be used to overcome pest problems.Keywords: Essential oil; plant pest; VOCs ABSTRAKPenggunaan pestisida secara berlebihan berbahaya bagi kesehatan dan lingkungan. Salah satu cara yang dapat digunakan dalam pengendalian hama yang ramah lingkungan yaitu dengan menggunakan minyak atsiri. Minyak atsiri diperoleh dengan mengekstraksi berbagai sumber botani. Minyak atsiri dapat diekstraksi dengan menggunakan berbagai metode. Salah satunya metode destilasi, dengan memisahkan uap air dan minyak. Minyak atsiri yang dapat digunakan untuk pengendalian hama salah satunya yaitu Volatile Organic Compounds (VOCs). Pada beberapa penelitian minyak atsiri telah teruji dapat bertindak sebagai repelen, fumigant maupun atraktan terhadap hama sehingga senyawa minyak atsiri dapat digunakan untuk mengatasi permasalahan hama.
Science-based, data-driven developments in plasma processing for material synthesis and device-integration technologies
Authors: Kambara Makoto , Kawaguchi Satoru , Lee Hae June , Ikuse Kazumasa , Hamaguchi Satoshi , Ohmori Takeshi , Ishikawa Kenji 
Published: September 2022

Abstract
Low-temperature plasma-processing technologies are essential for material synthesis and device fabrication. Not only the utilization but also the development of plasma-related products and services requires an understanding of the multiscale hierarchies of complex behaviors of plasma-related phenomena, including plasma generation in physics and chemistry, transport of energy and mass through the sheath region, and morphology- and geometry-dependent surface reactions. Low-temperature plasma science and technology play a pivotal role in the exploration of new applications and in the development and control of plasma-processing methods. Presently, science-based and data-driven approaches to control systems are progressing with the state-of-the-art deep learning, machine learning, and artificial intelligence. In this review, researchers in material science and plasma processing, review and discuss the requirements and challenges of research and development in these fields. In particular, the prediction of plasma parameters and the discovery of processing recipes are asserted by outlining the emerging science-based, data-driven approaches, which are called plasma informatics.
Pengaruh kombinasi kompres hangat dengan nafas dalam terhadap penurunan nyeri sendi pada lansia dengan rhematoid arthritis
Authors: Maelani Windy Silegar , Santoso Shelfi Dwi Retnani Putri , Wijaya Arif 
Published: September 2022

Rhematoid arthritis merupakan suatu penyakit yang menyerang persendian yang menimbulkan nyeri, kekakuan, pembengkakan, peradangan, dan keterbatasan gerak. Tindakan keperawatan non-farmakologi yang bisa mengurangi nyeri sendi pada lansia dengan rhematoid arthritis adalam kombinasi kompres hangat dengan nafas dalam. Tujuan penelitian untuk menganalisis pengaruh kombinasi kompres hangat dengan nafas dalam terhadap penurunan nyeri sendi pada lansia di Posyandu Lansia Dusun Mojo Desa Tampingmojo. Desain penelitian yang digunakan adalah desain quasy experiment. Populasi penelitian adalah lansia dengan rhematoid arthritis sebanyak 68. Sampel penelitian ini 22 responden dengan teknik purposive sampling. Teknik pengumpulan data menggunakan skala nyeri numeric rating scale, analisis data menggunakan uji statistik Wilcoxon rank dengan tingkat kesalahan 0,05. Hasil penelitian menunjukkan sebelum diberikan kombinasi kompres hangat dengan nafas dalam nyeri berat sebanyak 15 responden (68,2%) dan setelah diberikan kombinasi kompres hangat dengan nafas dalam nyeri ringan sebanyak 15 responden (68,2%). Hasil uji statistik Wilcoxon rank didapatkan nilai p = 0,000 < alpha 0,05 maka H1 diterima. Kesimpulan penelitian ini ada pengaruh kombinasi kompres hangat dengan nafas dalam terhadap penurunan nyeri sendi pada lansia dengan rhematoid arthritis. Pemberian kombinasi kompres hangat dengan nafas dalam ini dapat menurunkan nyeri sendi, merileksasikan otot, dan melancarkan peredaran darah.