bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant, cytotoxic, and anti-venom activity of Alstonia parvifolia Merr. Bark
Authors: Tan Maria Carmen S. , Carranza Mary Stephanie S. , Linis Virgilio C. , Malabed Raymond S. , Reyes Yves Ira A. , Franco Francisco C., Jr. , Oyong Glenn G. 
Published: March 2022

Objective:
To evaluate antioxidant, cytotoxic, and anti-venom capacity of crude bark extracts of Alstonia parvifolia Merr.

Methods:
Gas chromatography-mass spectrometry (GC-MS) and energy dispersive X-ray analyses were accomplished to characterize the chemical constituents of Alstonia parvifolia. Biochemical characterization was evaluated using an inhibitory phospholipase A2 (PLA2) assay, DPPH, and cytotoxicity assays. Using the constituents listed in the GC-MS analyses, molecular docking was conducted to inspect the binding energies between the chosen compounds and selected PLA2 isoforms.

Results:
GC-MS analyses showed that the Alstonia parvifolia crude extract consisted predominantly of acetylmarinobufogenin (14.89%), γ-sitosterol (10.44%), 3-O-methyl-D-glucose (5.88%), 3,5-dimethoxy-4-hydroxyphenylacetic acid (5.30%), (2α,5α)-17-methoxyaspidofractinin-3-one (AFM) (4.08%), and 2,3,5,6,7,8,9-heptahydro-1-phenyl-5-(p-chlorophenylimino)-1H-benzo[e][1
,
4]thiazepine (HPT) (1.37%). The principal elemental components of Alstonia parvifolia were Ca (4.012%) and K (1.496%), as exhibited by energy dispersive X-ray examination. Alstonia parvifolia showed significant free radical scavenging ability (IC50: 0.287 mg/mL) and was non-cytotoxic to normal HDFn cells (IC50 >100 μg/mL). Moreover, Alstonia parvifolia was favorably cytotoxic to MCF-7 (IC50: 4.42 μg/mL), followed by H69PR, HT-29, and THP-1, with IC50 values of 4.94, 5.07, and 6.27 μg/mL, respectively. Alstonia parvifolia also displayed notable inhibition against PLA2 activity of Naja philippinensis Taylor venom with IC50 of (15.2 ± 1.8) μg/mL. Docking and cluster analyses projected negative binding energies from AFM (-6.36 to -9.68 kcal/mol), HPT (-7.38 to -9.77 kcal/ mol), and acetylmarinobufogenin (-7.22 to -9.59 kcal/mol). These calculations were for the particular interactions of Alstonia parvifolia constituents to PLA2 homologues where the utmost affinity was detected in HPT owing to the dipole interactions with amino acid residues.

Conclusions:
The bark extract of Alstonia parvifolia shows great potential as an anti-venom agent due to its low cytotoxic profile, remarkable PLA2 inhibition, and docking binding energies between its bioactive constituents and PLA2 homologues.
Effect of Nano-Hydroxyapatite with Biomimetic Analogues on The Characteristics of Partially Demineralised Dentin
Authors: Nambiar Sharanya , Kumari Mohini , Mathew Sylvia , Hegde Swaroop , Ramesh Poornima , Shetty Nithin 
Published: March 2022

Background:
Research on dentin remineralisation protocols in particular ‘biomimetic remineralisation’ has gained huge momentum. Aim of this study was to evaluate if biomimetic analogs, incorporated in n-HAp, as an experimental formulation could aid in remineralization of artificial caries-like dentin and have anti-microbial effect on cariogenic bacteria, S mutans.

Materials and Methodology:
An experimental paste was formulated using nano-hydroxyapatite (nHAp) with Non-Collagenous Protein analogs- polyacrylic acid (PAA), sodium tri-poly phosphate (STPP) with Simulated Body Fluid. Partially demineralised dentin specimens were divided into three groups (n=10) based on the remineralisation treatment as, Group A- n-HAp paste, Group B- n-HAp and NCP analogues and Group C (Control) - no treatment. At the end of the experimental period, the specimens were assessed using SEM-EDS analysis and Vickers microhardness testing. Further, the antimicrobial efficacy of the paste was assessed.

Statistical Analysis:
The results were statistically analyzed using ANOVA with post-hoc Bonferroni test.

Results:
Dentin specimens treated with the experimental paste revealed greater tubular occlusion, with intra tubular deposits and increased mineral content. Specimens treated with n-HAp alone had higher microhardness values and inhibitory effect on the cariogenic bacteria.

Conclusion:
Non-Collagenous Protein analogs incorporated in n-HAp could remineralize the demineralised dentin and had antibacterial efficacy against S mutans.
Prevalence of Species-Specific Candidiasis and Status of Oral Hygiene and Dentition among Diabetic Patients
Authors: Duggal Ritu , Goswami Ravinder , Xess Immaculata , Duggal Isha , Talwar Aditya , Mathur Vijay Prakash 
Published: March 2022

Objective:
The study was undertaken to estimate the species-specific prevalence of oral candidiasis in diabetic individuals in India, and further find the relationship of oral carriage of Candida in diabetes with degree of diabetic control, duration of disease, type of diabetes and its effect on the status of oral hygiene status and decayed, missing and filled teeth (DMFT) score.

Methodology:
The prospective cross-sectional study involved 900 individuals (470 diabetic and 430 non-diabetic) visiting a tertiary care hospital. Informed consent was obtained from all the individuals participating in the study. The demographic details, medical history and oral cavity examination were recorded in a specially designed proforma. Swabs were taken for microbiological evaluation for specific prevalence of Candida.

Results:
The overall prevalence of Candida in diabetics was 22.1% as compared to 9.7% in non-diabetic individuals. However, among the type 1 and type 2 diabetics, the prevalence of Candida was equally distributed as 22.6% and 20.8%, respectively. C. albicans was the most common species (97.1%), while isolated cases of other species like C. rugosa, C. tropicalis, C. glabrata were also observed. The individuals with higher glycaemic score (HbA1c >7) showed higher prevalence of oral candidiasis. Oral hygiene status was observed to be lower among diabetics as compared to non-diabetic individuals.

Conclusion:
Oral candidiasis was more prevalent in diabetic patients, and C. albicans was the most common species. The diabetics also showed higher mean DMFT with lower oral hygiene status as compared to non-diabetic individuals.
Prevention of Typhoid Fever by Existing Improvements in Household Water, Sanitation, and Hygiene, and the Use of the Vi Polysaccharide Typhoid Vaccine in Poor Urban Slums: Results from a Cluster-Randomized Trial
Authors: Im Justin , Khanam Farhana , Ahmmed Faisal , Kim Deok Ryun , Kang Sophie , Tadesse Birkneh Tilahun , Chowdhury Fahima , Ahmed Tasnuva , Aziz Asma Binte , Hoque Masuma , Islam Md. Taufiqul , Park Juyeon , Liu Xinxue , Sur Dipika , Pak Gideok , Jeon Hyon Jin , Zaman Khalequ , Khan Ashraful Islam , Qadri Firdausi , Marks Florian , Kim Jerome H. , Clemens John D. 
Published: March 2022

ABSTRACT.
Modest improvements in household water, sanitation, and hygiene (WASH) and typhoid vaccination can reduce typhoid risk in endemic settings. However, empiric evaluation of their combined impact is lacking. A total of 62,756 persons residing in 80 clusters in a Kolkata slum were allocated randomly 1:1 to either the typhoid Vi polysaccharide (ViPS) vaccine or hepatitis A (Hep A) vaccine. Surveillance was conducted for 2 years before and 2 years after vaccination. We classified households as having “better” or “not better” WASH, and calculated the prevalence of better WASH households in clusters using previously validated criteria. We evaluated the protection by better household WASH, better household WASH prevalence, and ViPS vaccination against typhoid in all cluster members present at baseline using Cox proportional hazard models. Overall, ViPS vaccination was associated with a 55% (P < 0.001; 95% CI, 35–69) reduction of typhoid risk and was similar regardless of better WASH in the residence. Living in a better WASH household was associated with a typhoid risk reduction of 31% (P = 0.16; 95% CI, –16 to 59) overall. The reduction was 48% (P = 0.05; 95% CI, –1 to 73) in Hep A clusters, 6% (P = 0.85; 95% CI, –82 to 51) in ViPS clusters, and 57% (P < 0.05; 95% CI, 15–78) in the population during the 2 years preceding the trial. These findings demonstrate a preventive association of better household WASH in the non-ViPS population, but, unexpectedly, an absence of additional protection from ViPS by better WASH in the ViPS population. This analysis highlights the importance of assessing the combination of WASH in conjunction with typhoid vaccines, and has implications for the evaluation of new-generation typhoid conjugate vaccines.
PELATIHAN PENGELASAN SMAW BAGI KARANG TARUNA KELURAHAN TEMAS KECAMATAN BATU KOTA BATU
Authors: Arif Rochman Fachrudin  , Fina Andika Frida Astuti  , Mira Esculenta Martawati  , Ahmad Hanif  
Published: March 2022

Perguruan Tinggi mempunyai peran penting dalam Tri Darma, yaitu ikut dalam mencerdaskan kehidupan bangsa dan negara sencara nyata di masyarakat. Salah satu langkahnya adalah menjadikan manusia bukan lagi menjadi obyek pembangunan tetapi menjadi subyek pembangunan. Sebagai subyek pembangunan tentunya diperlukan kemampuan dan kecakapan dalam penguasaan ilmu pengetahuan dan teknologi. Pemanfaatan teknologi pengelasan telah berkembang dan banyak digunakan dan dimanfaatkan ditengah masyarakat luas, baik untuk skala industri rumah tangga maupun untuk perbaikan perbaikan peralatan dirumah. Salah satu metode pengelasan adalah pengelasan SMAW, yaitu pengelasan dengan menggunakan busur listrik.Tujuan dari kegiatan ini adalah meningkatkan pengetahuan secara umum remaja karang taruna kelurahan Temas Kecamatan Batu kota Batu, menambah ketrampilan kusus berupa pengelasan SMAW dan memberikan dorongan dan bantuan sehingga karang taruna kampung teh mampu mengadakan peralatan las.Manfaat dari kegiatan ini adalah memberikan pengetahuan dan melatih ketrampilan dalam pengelasan SMAW sehingga bisa digunakan untuk pengembangan pribadi maupun manfaat secara sosial
MODEL PEMULIHAN EKONOMI KELUARGA: SOLUSI BAGI PENYINTAS BENCANA TSUNAMI SELAT SUNDA DI PROVINSI BANTEN
Authors: Suseno Bambang Dwi , Almafutra Febi 
Published: March 2022

Tragedi yang dialami Provinsi Banten pada akhir tahun 2018 yang menerpa pesisir Pantai Selatan, telah mengakibatkan Bencana tsunami. Bencana tersebut mengakibatkan 437 korban jiwa, dan mengakibatkan kerusakan rumah dan fasilitas vital yang biasa dipakai masyarakat sekitar, berupa hotel, rumah, perahu, toko dan warung-warung sebagai modal usaha. Tulisan ini bertujuan untuk menggambarkan upaya rekonstruksi dapat memberikan kesempatan untuk mengurangi efek bencana di masa depan dengan meningkatkan kualitas konstruksi, menghindari lokasi berbahaya, dan meningkatkan komunitas kesadaran dan kesiapan. Rekonstruksi pascabencana dapat menawarkan peluang untuk perbaikan dan untuk memperbaiki masalah lama: untuk memperbarui infrastruktur, membuat pengaturan penggunaan lahan baru, meningkatkan standar konstruksi dan desain, menemukan kembali ekonomi, dan meningkatkan tata kelola. Kegiatan PKM yang telah dilaksanakan telah berhasil setidaknya menghidupkan kembali usaha-usaha sektor ekonomi, dengan memanfaatkan potensi-potensi lokal, bermanfaat untuk sekedar mengembalikan semangat hidup para korban khususnya di pesisir Kecamatan Cinangka Kabupaten Serang
ADOPSI METODE DELONE DAN MCLEAN UNTUK MENGANALISIS FAKTOR FAKTOR KESUKSESAN IMPLEMENTASI SISTEM INFORMASI (STUDI KASUS : E-APBS DI KOTA PEKALONGAN)
Authors: Sulistyorini Prastuti , Maulana Much. Rifqi , Kurniawan Ichwan 
Published: March 2022

Tujuan utama dari penelitian ini adalah untuk menetapkan faktor – faktor yang mempengaruhi kesuksesan implementasi aplikasi e-APBS di Dinas Pendidikan Kota Pekalongan. Pembentukan aplikasi e-APBS telah menjadi sebuah kebutuhan yang penting bagi Dinas Pendidikan Kota Pekalongan, karena aplikasi e-APBS digunakan untuk mengelola rencana anggaran dan belanja sekolah dengan sumber dana bantuan dari pemerintah untuk operasional sekolah. Aplikasi e-APBS merupakan inovasi Dinas Pendidikan Kota Pekalongan untuk mewujudkan pengelolaan anggaran yang akuntabel, transparan dan efektif. Untuk mengetahui faktor – faktor kesusesan implementasi aplikasi e-APBS, digunakan pendekatan model kesuksesan implementasi DeLone dan McLean. Indikator kesuksesan implementasi sistem menurut DeLone dan McLean meliputi kualitas sistem, kualitas informasi, kualitas layanan, tingkat penggunaan, kepuasan pengguna, dan manfaat bersih. Indikator yang tidak diukur dalam penelitian ini adalah penggunaan, karena aplikasi e-APBS ini merupakan prasyarat wajib untuk terwujudnya tata kelola keuangan yang semakin handal untuk meningkatkan pelayanan publik melalui transparansi, akuntabilitas, partisipasi dan keterbukaan dalam penyusunan perencanaan dan penganggaran di sekolah, sehingga harus digunakan. Penelitian ini mengadopsi penelitian deskriptif, dengan jumlah sampel 80 responden yang diambil dari operator bendahara aplikasi e-APBS. Metode pengumpulan data mengunakan kuesioner, dan menerapkan analisis analisis regresi untuk menganalisis data yang dikumpulkan oleh peneliti. Hasil penelitian menunjukkan bahwa faktor – faktor yang menentukan kesuksesan implementasi aplikasi e-APBS jika dilihat dari dimensi kepuasan pengguna adalah kualitas informasi dan kualitas layanan, dimensi penggunaan adalah kualitas sistem, dan dimensi manfaat bersih (net benefit) adalah kepuasan pengguna.
Kata kunci: Model Delone dan McLean, e-APBS.
Mothers’ Cooking: Perspectives of Givers and Takers
Authors: Ampansirirat Amavasee , Chukumnird Siriwan , Singhasem Prapaipis , Suwanraj Marisa , Phromjuang Kornwika 
Published: March 2022

The burden of malnutrition of children is a global challenge. Promoting mothers to prepare their own meals at home is indicated as an important strategy to prevent malnutrition and improve nutrition in children. Despite the fact that meals prepared by mothers are healthier, little is known about what cooking means in the Thai context. This descriptive qualitative research is intended to describe the perceptions and perspectives of mothers’ cooking among Thai mothers and school-age children. Descriptive qualitative research, using in-depth interviews with 10 mothers aged 31 to 80 years old and 10 school-age children aged 10 to 12 years old, was conducted. Participants were selected using purposive sampling from 10 sub-districts that are partners of the mothers’ cooking network project of Songkhla province. Data were analyzed using content analysis. The results provided by the mothers' and children's perspectives indicated that Thais perceived mothers’ cooking quite differently based on whether the perspective toward mothers is as the giver or whether the children addressed the perspective of the taker. For the giver, mothers’ cooking was defined in terms of the power of love, happiness time, feeling of self-worth, and mother’s role and responsibility. For the taker, mothers’ cooking was defined in terms of the best thing and the most delicious, family relationship, giving and sharing, and demonstration of love and care. Additionally, this study highlighted that the mother’s perception of cooking can be divided into 3 steps, namely, preparation, cooking and eating together. These findings may help in determining how public health programs can be improved and the role of mothers promoted within a healthy nutrition strategy.
HIGHLIGHTS

The provision of optimal nutrition during childhood is critical to good health, growth, and development
“Mother's cooking” is still a common tradition in Thai culture and daily life, but little is known about Thai attitudes toward mothers’ food
Cooking activities demonstrated the mothers’ love and transferred their wisdom to their children
Eating meals as a family strengthened bonds and became a family rule or habit passed down from generation to generation
A matemática na filosofia de Schopenhauer: Intuição versus demonstração por meio de um experimento
Authors: Frezzati Jr Wilson Antonio 
Published: March 2022

Schopenhauer opõe dois modos de se apreender o conhecimento matemático: intuição contra demonstração. Aqui, demonstração é a demonstração geométrica euclidiana a partir de princípios básicos e elementares. Intuição (em alemão, Anschauung ou Intuition) refere-se exatamente à apreensão imediata da noção a priori de espaço, ou seja, à intuição pura a priori de espaço. Para o filósofo alemão, esses dois tipos de conhecimento ocorrem por meio de duas faculdades distintas: a Razão (Vernunft), produtora dos conceitos utilizados na demonstração, e o Entendimento (Verstand), ligado às intuições. Os conceitos são formas transformadas das intuições e, por isso, menos confiáveis. Dessa forma, Schopenhauer propõe que a matemática deve ser aprendida pelo uso da intuição e não das demonstrações euclidianas. Nosso artigo investiga essa concepção schopenhauriana por meio do Teorema de Pitágoras. Apresentamos a proposta de Schopenhauer por meio de um experimento matemático, cujas conclusões serão tiradas pelo próprio leitor.
Aborto, una mirada desde los activismos feministas
Authors: Rojas Lozano Victoria Raquel , Ramírez Morales María del Rosario , Herrero Martín María Belén , Rodríguez Pedraza Yunitzilim , Rodríguez Falcón Margarita 
Published: March 2022

Aborto en México, una mirada desde los activismos feministas se publica en un contexto importante para el movimiento feminista mexicano que, después de años de movilización (1930-2021) y de conseguir la legalización del aborto en la Ciudad de México en 2007, logró la despenalización hasta el primer trimestre de gestación en cinco entidades de la República (Oaxaca, Veracruz, Hidalgo, Baja California y Colima), cuenta con el precedente histórico de las últimas resoluciones de la Suprema Corte de Justicia de la Nación (SCJN) y, sobre todo, ha mostrado su efectividad a través del número cada vez mayor de mujeres, niñas y personas gestantes que abortan de forma segura convencidas de que es su derecho. En este sentido, este dossier tiene como objetivo presentar el trabajo realizado por las colectivas de mujeres que han decidido acompañar desde la calle, en la intimidad de la casa, desde el celular o la presencialidad, frente a los Congresos locales o desde el activismo por redes sociales, uno de los procesos de la vida sexual (no) reproductiva: el aborto. La incorporación del tema dentro de la agenda pública y de los espacios de discusión académica se vuelve una tarea cada vez más relevante, tanto para rescatar la perspectiva de las personas directamente involucradas como para destacar el papel de los activismos y la incorporación de la narrativa vivencial de las activistas en la construcción de formas alternativas y encarnadas de nombrar, vivir y defender las decisiones sobre el cuerpo, la sexualidad y la reproducción.
La cultura de la alimentación. Patrimonio gastronómico de las sociedades en proceso de cambio y su difusión
Authors: Martínez García Rafael , Guilló Soler Borja , Picó Ledesma Isabel , Aniorte Pérez José , Tristán Richarte Marian 
Published: March 2022

La presente comunicación se aproxima a aquellas manifestaciones culturales que, en torno a la alimentación, se muestran en el Museo Escolar de Puçol (Elche). Desde sus inicios, este museo, surgido en la década de los setenta como resultado de un proyecto educativo que trascendió las aulas del colegio de esta pedanía ilicitana, caminó junto a una comunidad rural que ya entonces lo hizo suyo y lo ha venido arropando en todas aquellas iniciativas que ha liderado. La comunicación se divide en cuatro apartados, relacionados con las funciones esenciales de todo museo, esto es, la conservación, la investigación y la difusión, tal y como se desarrollan en el Museo Escolar, cuyos espacios reflejan, de manera transversal, la alimentación, entendida en sus varias acepciones. En primer lugar, se describen los procesos agrícolas tradicionales del Camp d’Elx -y del entorno Mediterráneo-, asociados a los cultivos del cereal, de la vid y del olivo. Junto a ellos, se incluyen producciones más recientes, como la almendra o la ñora, que también tienen su reflejo en el discurso del museo. De manera transversal, el agua siempre está presente, habida cuenta de lo esencial que resulta su concurso tanto para el abastecimiento como para el regadío. En segundo lugar, se describe la elaboración de alimentos en el ámbito doméstico a partir de estos productos, recetas y procesos compilados gracias a la recuperación de la memoria oral que se realiza en el seno del proyecto educativo desde sus orígenes. En tercer lugar, se habla del consumo y la comercialización de los productos relacionados con la alimentación en los bares y en las tiendas, tanto los productos llamados actualmente “de proximidad” como de cualesquiera otros presentes en los populares establecimientos de “ultramarinos”, reproducidos en el museo. En cuarto lugar, la comunicación se refiere a la difusión que desde el Proyecto Pusol se lleva a cabo de todo lo anteriormente descrito, es decir, la difusión de los procesos y prácticas sociales relacionados con la alimentación, difusión entendida tanto en el contexto educativo formal -es decir, incorporada al Proyecto Educativo-Museístico-, como en la dinámica propia del museo: exposiciones, cartelas, trípticos, visitas guiadas -en las que la participación de los/as escolares resulta esencial-, talleres o publicaciones.
An approach to the modeling of honey bee colonies
Authors: Romero-Leiton Jhoana P. , Gutierrez Alejandro , Benavides Ivan Felipe , Molina Oscar E. , Pulgarín Alejandra 
Published: March 2022

Abstract. In this work, populations of adult and immature honeybees and their honey production are studied through mathematical and statistical modeling approaches. Those models are complementary and are presented in disjunct form. They were used to show different modeling methods for honey bee population dynamics. The statistical approach consisted of a generalized linear model using data from the Department of Agriculture of the United States of America (USDA), which showed that the relationship between the number of colonies and the rate of honey production is not constant in time but decrease over the years. These models showed that when a bee population is subjected to a stress factor (i.e., habitat destruction, Varroa mite, climate variability, season, neonicotinoids, among others), the abundance of individuals decreases over time as well as the honey produced by the colonies. Finally, the mathematical approach consisted of two models: (1) a smooth model, in which conditions of existence and stability of the equilibrium solutions are determined by an ecological threshold value, and (2) a non-smooth model where the mortality rate of bees is included as a function of the number of adult bees in the population.
Experience of a Medical Intern in a Secondary Healthcare Hospital in Mexico
Authors: Delgado Sánchez Jonathan Dazaeth 
Published: March 2022

In Mexico, medical training is characterized by 4 or 5 years of studies at a university campus, one year of undergraduate internship and one year of social service. The undergraduate internship is the theoretical-practical academic cycle that takes place in the clinical fields and is part of the curriculum of the medical career. Normally we expect to be able to choose a hospital with subspecialties or with prestige in our region. But no matter the type of hospital, the important thing is our attitude to work and learn.