bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 1-MV low-jitter high-reliability multi-stage equal breakdown probability gas switch
Authors: Shang Wei , Su Jiancang , Zeng Bo , Gao Mingzhu , Li Rui , Li Yongdong , Lv Donghui , Shao Shuai 
Published: December 2022

Abstract
This paper presents the development of a novel megavolt-class equal breakdown probability (EBP) multi-stage self-discharge gas switch for high power microwave generation with low breakdown jitter and high reliability. With the joint distribution of breakdown probability for ‘n’ identical stages of EBP gas switch, the advantages of diminishing the breakdown jitter and omitting the complex breakdown order problem are hence disclosed in considerable details with the aid of probability computation method. Based on theoretical analysis, a 5 stages 1-MV EBP multi-stage gas switch is designed in which periodic cog profile cathode is proposed to further decrease the breakdown jitter. The performances of EBP switch are tested at the repetition rate of 1,10,20,50 Hz over 1000 successive pulses with breakdown jitter as low as 2.7% ,energy efficiency as high as 90% and pulse rising time as low as 5 ns. The overall performance of EBP gas switch shows great potential in compact and reliable high power microwave generating system.
Constraining ultra-high-energy cosmic ray composition through cross-correlations
Authors: Tanidis Konstantinos , Urban Federico R. , Camera Stefano 
Published: December 2022

Abstract
The chemical composition of the highest end of the ultra-high-energy cosmic ray spectrum is very hard to measure experimentally, and to this day it remains mostly unknown. Since the trajectories of ultra-high-energy cosmic rays are deflected in the magnetic field of the Galaxy by an angle that depends on their atomic number Z, it could be possible to indirectly measure Z by quantifying the amount of such magnetic deflections. In this paper we show that, using the angular harmonic cross-correlation between ultra-high-energy cosmic rays and galaxies, we could effectively distinguish different atomic numbers with current data. As an example, we show how, if Z = 1, the cross-correlation can exclude a 39% fraction of Fe56 nuclei at 2σ for rays above 100 EeV.
Investigating the fission dynamics of the following neutron shell closed nuclei within a stochastic dynamical approach: 210Po, 212Rn, and 213Fr*
Authors: Arora Divya , Sugathan P. , Chatterjee A. 
Published: December 2022

Abstract
The dissipative dynamics of nuclear fission is a well confirmed phenomenon that can be either described by a Kramers-modified statistical model or by a dynamical model employing the Langevin equation. Although dynamical models as well as statistical models incorporating fission delays have been found to explain the measured fission observables in several studies, they present conflicting results for shell closed nuclei in the mass region of 200. Notably, an analysis of the recent data on neutron shell closed nuclei in the excitation energy range of 40

80 MeV failed to provide a satisfactory description of the data, which was attributed to a mismatch with shell effects and/or entrance channel effects, without reaching a definite conclusion. In the present study, we demonstrate that a well established stochastic dynamical code can simultaneously reproduce the available data for pre-scission neutron multiplicities and fission and evaporation residue excitation functions for the following neutron shell closed nuclei

Po and

Rn and their isotopes

Po and

Rn without the need for including any extra shell or entrance channel effects. The relevant calculations are performed by using a phenomenological universal friction form factor with no ad-hoc adjustment of the model parameters. However, we note a significant deviation, beyond experimental errors, for some Fr isotopes.
Elongation effect on beta-induced Alfvén eigenmode
Authors: Li Gengxian , Li Yueyan , Xiao Yong 
Published: December 2022

Abstract
Beta induced Alfvén eigenmode (BAE) can be an important candidate for ion loss in burning plasmas. Elongation effect on BAE has been investigated by the gyrokinetic eigenvalue code DAEPS in this work. We construct a shaped equilibrium model by modifying local s − α model with which the capability of the DAEPS code has been extended to study the elongation effect. It is discovered that the BAE growth rate first increases with elongation factor κ, reaches a maximum and then decreases. This trend occurs for many different values of η
i. We find that, in the weak or moderate elongation region, the BAE instability is reactive type and mainly determined by the fluid/MHD effects, namely the combination of stabilizing field line bending term and destabilizing interchange drive in the vorticity equation. However, in the strong elongation region, the BAE instability becomes dissipative and is mainly driven by the wave–particle resonance effect embedded in δW

k
since the fluid driving damps away. It is also discovered that the wave–particle resonance decreases with elongation in this region, which is due to the decrease of the geodesic curvature with elongation and leads to the decrease in the growth rate of BAE.
A two-step strategy to deposit a hydroxyapatite coating on polydopamine-coated polymer fibers
Authors: Li Jiaxin , Li Ting-Ting , Zhang Ying , Shiu Bing-Chiuan , Lin Jia-Horng , Lou Ching-Wen , Liu Liyan 
Published: December 2022

Abstract
As the main inorganic component of human bones and teeth, hydroxyapatite (HA), with excellent bioactivity and biocompatibility, shows great potential in the bone tissue engineering field. Marine mussel-inspired polydopamine (PDA) possesses unique functional groups and thus can absorb the calcium ions from extracellular fluid, thereby triggering the precipitation of HA. This study is based on a two-step strategy. Using the chemical activity of PDA, polyvinyl alcohol/polylactic acid (PVA/PLA) braids were coated with a PDA layer that served as a template for the electrochemical deposition of a HA layer. The test results indicate that the resulting HA crystals were assembled on the polymer fibers in an urchin-like mannerwith a stratified structure. Subsequently, the HA/PDA-PVA/PLA braided bone scaffolds were immersed in simulated body fluid for ten days, after which the bone scaffolds were found to be completely coated with HA, indicating a good biomineralization capability. Cell activity of HA/PDA-PVA/PLA scaffolded by dopamine-assisted electrodeposition was 178.8% than that of PVA/PLA braids. This HA coating layer inspired by biochemical strategies may be useful in the field of bone tissue engineering.
Active mode single-pixel non-line-of-sight imaging system based on second-order correlation and diffraction
Authors: Li Mengdi , Xu Xiping , Wang Xiaoqian , Yao Zhihai , Wang Xin 
Published: December 2022

Abstract
Non-line-of-sight (NLOS) imaging relies on capturing light that has been weakened due to multiple reflections and recovering the occluded scene with high quality is very challenging. To improve the quality of NLOS imaging, an active mode single-pixel NLOS imaging reconstruction framework based on the second-order correlation function and diffraction inverse operation is proposed. Under the collective effect of illumination pattern and single-pixel detector light intensity, the inverse imaging problem is first solved by a statistically weighted average, and then, an additional process is connected to reduce the influence of diffraction on reconstructed image quality based on the Fourier transform and inverse diffraction operation. The simulation and experimental results show that the proposed method with the Hadamard pattern and diffraction inverse operation, which achieved the SSIM value of 0.9286, is superior to the random pattern at a full sampling rate. The lens aperture size, pattern location, and the number of measurements have a significant effect on the system. Therefore, the proposed scheme has potential practical applications.
Modeling study on different discharge characteristics in pulsed discharges with and without barriers on electrodes
Authors: GAO Shuhan , WANG Xucheng , ZHANG Yuantao 
Published: December 2022

Abstract
High-pressure nanosecond pulsed discharges (NPDs) have attracted increasing attention in recent years due to their wide potential applications. In this study, a barrier-free NPD in pure helium plasma at 120 Torr was numerically investigated by a one-dimensional self-consistent fluid model, and its current–voltage characteristics show very different behaviors from those in pulsed dielectric barrier discharges (DBDs), indicating an entirely distinctive discharge evolution in pulsed discharges with or without barriers on electrodes. Without the control of barriers, the computational data suggest that the discharge current increases very sharply during the plateau phase of the pulsed voltage and reaches its peak value at approximately the instant when the pulsed voltage starts to drop, together with a gradual reduction in the sheath thickness and an increase in electric field in the sheath region, which is in good agreement with experimental observations. By increasing the voltage plateau width and repetition frequency, the discharge current density from the simulation can be substantially enhanced, which cannot be observed in conventional pulsed DBDs, and the spatial distributions of the electric field and charged particles are given to unravel the underlying physics. From the computational data, the distinctive discharge characteristics in barrier-free NPDs are deeply understood, and could be further optimized by tailoring the waveform of the pulsed voltage to obtain desirable plasmas for applications.
High-resolution maskless patterning of AgNWs based on adhesion enhancement of a printed conductive polymer
Authors: Kim Geonhee , Yoon Jinsu , Yoon Hyungsoo , Cho Hyeon , Seo Jiseok , Hong Yongtaek 
Published: December 2022

Abstract
Facile high-resolution patterning of silver nanowires (AgNWs) is a key enabling technology for expanding their usage to flexible and stretchable electronics applications. Although various patterning methods have been proposed, only high-cost and complex mask-based methods have demonstrated potential micrometer-scale pattern-ability, which have no design freedom of changing patterns in a facile manner. Herein, we suggest a maskless high-resolution patterning method by combining an adhesive underlayer and inkjet-printed conductive polymer patterns. AgNWs located between them are tightly bonded and thus are resistant to a solvent-based rinsing process. AgNWs under the conductive polymer patterns remain while uncovered AgNWs are removed during the rinsing process. Our approach allows easy patterning of AgNWs on various substrates including glass, plastic, and stretchable elastomer. The excellent mechanical properties of AgNW interconnects are demonstrated in a stretchable light-emitting diode array. By introducing an electrohydrodynamic printing method, high-resolution AgNW patterns with linewidths below 20 µm are fabricated, which are used for a heater based on transparent grid AgNW electrodes. Based on our results, we believe that our method paves the way for a convenient patterning process of high-resolution electrode circuits with a high degree of freedom even on a deformable platform.
Hardiness and Grit as Drivers of South African Child Protection Social Workers’ Occupational Resilience
Authors: Molakeng Mahloma Hebert , Boonzaaier Emma , Truter Elmien , Fouché Ansie 
Published: December 2022

Abstract
Child protection social workers (CPSWs) perform statutory duties and often work in hostile work contexts. Nevertheless, some CPSWs are reportedly resilient, thus adjusting well despite exposure to occupational adversities. We followed a qualitative descriptive design in which twenty CPSWs from the Western Cape and the Free State provinces described their sources of occupational resilience during semi-structured interviews. Their self-reported sources of resilience were informed by (1) a high degree of personal agency; (2) navigating a responsive and supportive ecology; (3) commitment to a meaningful purpose; (4) prioritising self-care and (5) religious practices. These sources of resilience confirm what we already know, but our findings go beyond earlier reports and contribute towards a more nuanced understanding of how hardiness and grit fundamentally drive the occupational resilience of CPSWs.
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis
Authors: Qiao Bing , Chen Lei , Cheng Qianwen , Wang Guangqi , Li Qun , Zhang Bo , Li Junying , Hu Yu , Sun Chunyan 
Published: December 2022

Abstract
CCL18 has recently been implicated in malignancies and is increasingly mentioned as a potential tumoral biomarker and furtherly a molecular target for therapeutic intervention, but its expression and clinical significance in multiple myeloma have not been explored. Serum CCL18 levels were measured by ELISA method in 254 newly diagnosed multiple myeloma (NDMM), 21 monoclonal gammopathy of undetermined significance (MGUS) and 22 healthy adults. The study suggests that the serum CCL18 level in NDMM patients was significantly higher than that in MGUS and healthy adults. High level of CCL18 were associated with advanced ISS and R-ISS stages in MM. Patients with high serum CCL18 displayed a significantly more frequent occurrence of renal impairment and hypercalcemia, while the proportion of achieving complete remission (CR) was lower. More importantly, Cox analysis identified CCL18 and LDH as independent predictors of PFS in MM patients, whereas CCL18, creatinine and LDH were independent predictors of OS. Finally, we show that CCL18 can promote migration and invasion of myeloma cell lines RPMI8226 and MM.1S. CCL18 may play a tumor-promoting role by increasing the migration and invasion abilities of myeloma cells.
Functional conservation of Anopheline linalool receptors through 100 million years of evolution
Authors: Huff Robert M , Pitts Ronald Jason 
Published: December 2022

Abstract
Insects rely on olfactory receptors to detect and respond to diverse environmental chemical cues. Detection of semiochemicals by these receptors modulates insect behavior and has a direct impact on species fitness. Volatile organic compounds (VOCs) are released by animals and plants and can provide contextual cues that a blood meal host or nectar source is present. One such VOC is linalool, an enantiomeric monoterpene, that is emitted from plants and bacteria species. This compound exists in nature as one of two possible stereoisomers, (R)-(–)-linalool or (S)-(+)-linalool. In this study, we use a heterologous expression system to demonstrate differential responsiveness of a pair of Anopheline odorant receptors (Ors) to enantiomers of linalool. The mosquitoes Anopheles gambiae and Anopheles stephensi encode single copies of Or29 and Or53, which are expressed in the labella of An. gambiae. (S)-(+)-linalool activates Or29 orthologs with a higher potency than (R)-(–)-linalool, while the converse is observed for Or53 orthologs. The conservation of these receptors across a broad range of Anopheline species suggests they may function in the discrimination of linalool stereoisomers, thereby influencing the chemical ecology of mosquitoes. One potential application of this knowledge would be in the design of novel attractants or repellents to be used in integrated pest management practices.
Impact of farmers’ social relationships on productivity: a multiplex network analysis
Authors: Gambrah Patience Pokuaa , Yu Qian 
Published: December 2022

Abstract
An individual’s productivity is strongly related to work- and non-work-related interactions. Thus, the literature on farmers’ productivity often explores single-layer networks that illustrate the single categories of social relationships. In this study, we investigated farmers’ productivity using a multiplex structure underlying social interaction networks. Relational data were obtained from farmers in four different categories of social relationships. The multiplex network was analysed by applying multiplex degree centrality and layer-by-layer comparison. Also, power and role were analysed through the use of external data by determining their intra-layer correlation. The findings show that diverse types of relationships exist together and they positively affect farmers’ productivity in multiple ways and enhance their innovation capacity. Only 6 out of the 73 farmers had high-degree centrality (&gt; 10), with 18–63$\%$ relevance for the six farmers in the two layers—farming advice (FA) and loans (LO) layers—that the farmers considered important to their productivity. These farmers were more likely to be productive and help improve the productivity of others linked to them. Further, 62$\%$ of the edges in the social gathering and personal advice layers were similar, whereas only 3$\%$ of those in the FA and LO layers were similar, confirming the significance of the latter layers. The influence of social structures on farmers’ productivity implies that social connections enhance farmers’ confidence. The external data further confirm that the formation of some links depends on trust and power, whereas others do not.
Clinical outcomes and gut microbiota analysis of severe alcohol-associated hepatitis patients undergoing healthy donor fecal transplant or pentoxifylline therapy: single-center experience from Kerala
Authors: Philips Cyriac Abby , Ahamed Rizwan , Rajesh Sasidharan , Singh Shobhit , Tharakan Ajit , Abduljaleel Jinsha K , Augustine Philip 
Published: December 2022

Abstract

Background
Severe alcohol-associated hepatitis (SAH) patients with infections have a high short-term mortality rate. Gut microbiota dysbiosis plays an important role in the pathogenesis of SAH. Preliminary studies have demonstrated long-term benefits with healthy donor fecal microbiota transplantation (FMT). Data on FMT compared with pentoxifylline for SAH and relevant gut microbial changes are lacking in literature.

Methods
From January 2019 to February 2021, retrospective analysis of a single hospital’s records revealed 47 SAH patients undergoing FMT (100 mL/day via nasoduodenal tube for 7 days) and 25 matched patients receiving pentoxifylline (400 mg/8 h for 28 days). The primary end point was a 6-month survival rate. Secondary end points included incidence of ascites, hepatic encephalopathy, infections, acute kidney injury, and gut microbiota changes between post-therapy groups. Biomarker discovery and network analysis were also performed to identify significant taxa of gut microbiota in post-treatment groups in retrospectively stored stool samples.

Results
All were males. The 6-month survival rate was higher in the patients undergoing FMT than in patients receiving pentoxifylline (83.0% vs 56.0%, P = 0.012). At the end of 6-month follow-up, the incidences of clinically significant ascites (56.0% vs 25.5%, P = 0.011), hepatic encephalopathy (40.0% vs 10.6%, P = 0.003), and critical infections (52.0% vs 14.9%, P &lt; 0.001) in patients administered pentoxifylline were significantly higher than those in patients treated with FMT. At 3 months, biomarker analysis revealed a significant abundance of Bifidobacterium and Eggerthella in the FMT group and the pentoxifylline group, respectively. At 6 months, Bifidobacterium in the FMT group and pathogenic Aerococcaceae in the pentoxifylline group were notable. Network analysis showed beneficial taxa (Bifidobacterium) as a central influencer in those undergoing FMT at 6 months.

Conclusions
Healthy donor FMT improved survival rate and reduced liver-related complications compared with pentoxifylline. These clinical benefits were associated with favorable modulation of intestinal bacterial communities. Difficult-to-treat SAH patients may be safely bridged to transplantation using FMT. Controlled trials evaluating long-term outcomes are an unmet need.
Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability and facial anomalies syndrome with distinctive genome-wide DNA hypomethylation
Authors: Unoki Motoko , Velasco Guillaume , Kori Satomi , Arita Kyohei , Daigaku Yasukazu , Yeung Wan Kin Au , Fujimoto Akihiro , Ohashi Hirofumi , Kubota Takeo , Miyake Kunio , Sasaki Hiroyuki 
Published: December 2022

Abstract
Immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome is in most cases caused by mutations in either DNA methyltransferase (DNMT)3B, zinc finger and BTB domain containing 24, cell division cycle associated 7 or helicase lymphoid-specific. However, the causative genes of a few ICF patients remain unknown. We, herein, identified ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) as a novel causative gene of one such patient with atypical symptoms. This patient is a compound heterozygote for two previously unreported mutations in UHRF1: c.886C &gt; T (p.R296W) and c.1852C &gt; T (p.R618X). The R618X mutation plausibly caused nonsense-mediated decay, while the R296W mutation changed the higher order structure of UHRF1, which is indispensable for the maintenance of CG methylation along with DNMT1. Genome-wide methylation analysis revealed that the patient had a centromeric/pericentromeric hypomethylation, which is the main ICF signature, but also had a distinctive hypomethylation pattern compared to patients with the other ICF syndrome subtypes. Structural and biochemical analyses revealed that the R296W mutation disrupted the protein conformation and strengthened the binding affinity of UHRF1 with its partner LIG1 and reduced ubiquitylation activity of UHRF1 towards its ubiquitylation substrates, histone H3 and proliferating cell nuclear antigen -associated factor 15 (PAF15). We confirmed that the R296W mutation causes hypomethylation at pericentromeric repeats by generating the HEK293 cell lines that mimic the patient’s UHRF1 molecular context. Since proper interactions of the UHRF1 with LIG1, PAF15 and histone H3 are essential for the maintenance of CG methylation, the mutation could disturb the maintenance process. Evidence for the importance of the UHRF1 conformation for CG methylation in humans is, herein, provided for the first time and deepens our understanding of its role in regulation of CG methylation.
Intransigent vs. volatile opinions in a kinetic epidemic model with imitation game dynamics
Authors: Della Marca Rossella , Loy Nadia , Menale Marco 
Published: December 2022

Abstract
In the mathematical epidemiology community, there is an increasing interest in shaping the complex interplay between human behaviour and disease spreading. We give a contribution in this direction by illustrating a method to derive behavioural change epidemic models from a stochastic particle description by the means of kinetic equations. We consider a susceptible–infected–removed-like model where contact rates depend on the behavioural patterns adopted across the population. The selection of the social behaviour happens during the interactions between individuals adopting alternative strategies and it is driven by an imitation game dynamics. Agents have a double microscopic state: a discrete label, which denotes the epidemiological compartment to which they belong, and the degree of flexibility of opinion, i.e. a measure of the personal attitude to change opinion and, hence, to switch between the alternative social contact patterns. We derive kinetic evolution equations for the distribution functions of the degree of flexibility of opinion of the individuals for each compartment, whence we obtain macroscopic equations for the densities and average flexibilities of opinion. After providing the basic properties of the macroscopic model, we numerically investigate it by focusing on the impact of the flexibility of opinion on the epidemic course and on the consequent behavioural responses.