bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Alantolactone on Stemness Genes Expression and
Epithelial-Mesenchymal Transition (EMT) in Breast Cancer via
STAT3 Suppression
Authors: Aziz Shiva Gholizadeh-Ghaleh , Kashefi Saiedeh , Khalaji Naser 
Published: February 2022

Background:
To reduce the side effects of conventional chemotherapy drugs, new herbal
remedies, such as alantolactone, can be used.

Objective:
We evaluated the association between stemness and EMT (epithelial-mesenchymal transition)
process in triple-negative breast cancer cells treated with alantolactone that targets STAT3.

Methods:
The MDA-MB-231 cell line was used as one of the triple-negative breast cancer cell lines.
MTT assay was used to evaluate cell viability and alantolactone dose at three-time points of 24, 48,
and 72 hours, and three doses, i.e., 1, 0.1, and 0.01 μM of alantolactone were used to evaluate cellular
behavior in proliferative and invasion pathways, respectively. A scratch test was also performed to
evaluate the invasive power of cancer cells. Real-time PCR was used to evaluate the expression of
regular genes by cancerous cell proliferation, STAT3 NANOG, SOX-2, and E-cadherin metastasis.

Results:
It was observed that increasing the dose of alantolactone decreased proliferation and metastasis
rate. The three doses selected for the cell culture study did not differ significantly from the control
group regarding apoptosis-inducing abilities at desired time intervals. Expression of SOX-2, STAT3,
and NANOG in the treated cells decreased with increasing dose of the alantolactone, whereas expression
of E-cadherin was found to be increased.

Conclusion:
Alantolactone through the STAT3 signaling pathway affects the expression of Ecadherin,
NANOG, and SOX2 genes, inhibiting the EMT process and subsequent stemness, and may
potentially be used in therapeutics for cancer patients.
Perceptions on the Use of Wearable Sensors and Continuous Monitoring in Surgical Patients: Interview Study Among Surgical Staff
Authors: Joshi Meera , Archer Stephanie , Morbi Abigail , Ashrafian Hutan , Arora Sonal , Khan Sadia , Cooke Graham , Darzi Ara 
Published: February 2022

Background
Continuous vital sign monitoring by using wearable sensors may result in the earlier detection of patient deterioration and sepsis. Few studies have explored the perspectives of surgical team members on the use of such sensors in surgical patients.

Objective
This study aims to understand the views of surgical team members regarding novel wearable sensors for surgical patients.

Methods
Wearable sensors that monitor vital signs (heart rate, respiratory rate, and temperature) continuously were used by acute surgical patients. The opinions of surgical staff who were treating patients with these sensors were collated through in-depth semistructured interviews to thematic saturation. Interviews were audio recorded, transcribed, and analyzed via thematic analysis.

Results
A total of 48 interviews were performed with senior and junior surgeons and senior and junior nurses. The main themes of interest that emerged from the interviews were (1) problems with current monitoring, (2) the anticipated impact of wearables on patient safety, (3) the impact on staff, (4) the impact on patients overall, (5) potential new changes, and (6) the future and views on technology.

Conclusions
Overall, the feedback from staff who were continuously monitoring surgical patients via wearable sensors was positive, and relatively few concerns were raised. Surgical staff members identify problems with current monitoring and anticipate that sensors will both improve patient safety and be the future of monitoring.
Quien tiene otra lengua vale por dos ...
Authors: Gutiérrez Haces Rosario , Jurado Salinas Martha 
Published: February 2022

El Examen de Posesión de la Lengua Española (EPLE) es un instrumento de evaluación que se aplica exclusivamente a personas cuya lengua materna no es el español, para determinar el nivel de dominio que de él tienen como lengua extranjera.
Un extranjero puede llegar a dominar una lengua por distintos medios: la interacción lingüística con hispanohablantes, experiencia comunicativa en países donde se habla español, participación en cursos, autoaprendizaje; o todos ellos. Todas estas experiencias lingüísticas le proporcionan un conocimiento de la lengua y un dominio pragmático que, en una situación de evaluación, le permitirán tener un desempeño "proficiente"; por lo tanto, no se evalúan esfuerzos sino resultados. Los puntos obtenidos en el examen reflejan distintos grados de dominio en cada una de las cuatro habilidades, no hay reprobados (suspendidos), porque se trata de evaluar niveles de lengua, no aptitud para aprobar cursos.
El conjunto de actividades evaluadas en las cuatro habilidades, junto con el nivel de actuación alcanzado en cada una de ellas, conforman un perfil que representa la "proficiencia" o dominio global del sujeto. Con base en este examen, el Centro de Enseñanza para Extranjeros (CEPE), de la Universidad Nacional Autónoma de México (UNAM), otorga una certificación de competencia lingüística que permite contar con un indicador de la capacidad del candidato para desenvolverse lingüísticamente en diversas situaciones de tipo académico, laboral y social.
Prácticas de alimentación infantil de cuidadores principales, conducta alimentaria y estado nutricional de preescolares en Chile
Authors: Rivera Muñoz Leyla , Nazar Gabriela 
Published: February 2022

Este estudio tuvo como objetivo conocer la relación entre estado nutricional, prácticas de alimentación del cuidador y conducta alimentaria en preescolares de una comuna del centro sur de Chile. La muestra estuvo compuesta por 249 preescolares y sus cuidadores principales. Se encontró una relación positiva entre índice de masa corporal (IMC) del niño y preocupación por el peso del niño (r=.512 p < 0.01) y entre IMC del niño y alimentación restrictiva del cuidador (r=.202, p < 0.01). Se encontraron relaciones débiles aunque significativas entre estado nutricional (IMC y % de grasa corporal) y conducta alimentaria en niños. Análisis de correlaciones canónicas indicaron que las variables agrupadas de prácticas de alimentación infantil, se relacionaron positivamente con el estado nutricional del niño (ρ3=0.5425, <0.001**). Adicionalmente, se encontró que la preocupación por el peso del niño mediaba parcialmente la relación entre restricción alimentaria e IMC (IC 95% efecto indirecto "ab" [.02; .13]) y entre restricción y porcentaje de grasa corporal (IC 95% efecto indirecto "ab" [.06; .5])Las actitudes y prácticas de alimentación infantil de los cuidadores principales, particularmente la preocupación por el peso del niño y la restricción en la alimentación juegan un rol crítico en la mantención y manejo de la obesidad en preescolares. Se exploran las implicancias prácticas de estos hallazgos.
Perbedaan Hasil Belajar Kognitif Siswa Pada Pembelajaran Daring Melalui Google Classroom dan Whatsapp Mesenger Di SMP Negeri 4 Bengkulu Tengah
Authors: Alianto Alianto , Hasan R , Irwandi Irwandi 
Published: February 2022

Cognitive learning outcomes of students in learning biology are still low. This study aims to determine the differences in students' cognitive learning outcomes in online learning through google classroom and whatsapp messenger at SMP Negeri 4 Bengkulu Tengah. The research was carried out in January-March 2021, using pre-experimental research methods, pre-experimental one group pre-test-post-test design. The population is class VIII SMPN 4 Bengkulu Tengah, totaling 86 students, with a sample of 43 students. Collecting data with test questions of students' cognitive learning outcomes. The results showed that there was no difference between students' cognitive learning outcomes in online learning through google classroom and whatsapp messenger at SMPN 4 Bengkulu Tengah.
Abstrak. Hasil belajar kognitif siswa dalam pembelajaran biologi masih rendah. Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar kognitif siswa pada pemebelajaran daring melalui google classroom dan whatsapp mesenger Di SMP Negeri 4 Bengkulu Tengah. Penelitian dilaksanakan pada bulan Januari-Maret 2021, menggunakan metode penelitian pra eksperimen, desain pre-eksperiment one group pre-test-post-test. Populasi adalah siswa kelas VIII SMPN 4 Bengkulu Tengah yang berjumlah 86 siswa, dengan sampel 43 siswa. Pengumpulan data dengan soal tes hasil belajar kognitif siswa. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan antara hasil belajar kognitif siswa pada pembelajaran daring melaui google classroom dan whatsapp mesenger Di SMPN 4 Bengkulu Tengah.
Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract
Authors: Soto Fernando , Purcell Emma , Ozen Mehmet Ozgun , Sinawag Prima Dewi , Wang Jie , Akin Demir , Demirci Utkan 
Published: February 2022

Developing on-site biomarker enrichment platforms could help to improve
the diagnosis of gastrointestinal (GI) tract diseases at early stages.
Medical procedures, such as colonoscopies and imaging techniques, are
used to diagnose disease, but are not easily accessible for repeat
measurements. In the other hand, liquid biopsies, e.g., blood,
urine, or fecal samples, have become important sampling strategies to
identify health concerns. Herein, a robotic pill is designed for
collecting relevant biomarkers from the GI over prolonged sampling
periods. The robotic pill comprises a magnetic core for locomotion, a
delayed gate mechanism that controls sampling location based on changes
in its environment, and an enrichment module that traps biomarkers in an
absorbent matrix while enabling biofluid to pass through the chamber.
The robotic pill was assessed to sample microparticles, proteins, and
bacteria from solution. Moreover, the robotic pill was capable of
directed locomotion in complex environments and docking in a targeted
region against fluid flow. Utilization of an untethered robotic sampling
system could provide a tool to investigate aspects of disease initiation
and progression for early diagnosis and therapy monitoring.
Estrategias asociativas para las organizaciones solidarias en el marco del posconflicto en el Tolima
Authors: Ávila Suárez Karen Dahianna , GarcÍa Solano Sandra Lorena 
Published: February 2022

El proceso de paz que se ha llevado en Colombia ha impulsado que las víctimas o victimarios del conflicto armado vean la constitución de las organizaciones solidarias como una alternativa de vida. Ya que de esta manera se genera una activa participación en el sector empresarial y en el mercado laboral, donde se logra obtener beneficios comunes como: mejorar la calidad de vida de los asociados, la reducción de las brechas de la desigualdad y pobreza causadas por el conflicto y la contribución en la construcción de territorios de paz. Por consiguiente, nace la importancia de diseñar estrategias asociativas que fortalezcan a las organizaciones solidarias que involucran a personas pertenecientes en el conflicto armado para generar un desarrollo sostenible, perdurable y competitivo en el mercado.
Lo que conlleva a plantear los siguientes objetivos específicos: (i) Realizar un diagnóstico los procesos de asociatividad de las organizaciones solidarias en el marco del posconflicto, (ii) Identificar las principales problemáticas asociativas de las organizaciones, y (iii) Elaborar estrategias de asociatividad para impulsar el desarrollo comercial de sus procesos productivos. Por tanto, la metodología de esta investigación es de tipo descriptivo - propositiva, ya que caracterizan los procesos internos que se llevan a cabo en las organizaciones solidarias y se proponen diversas estrategias asociativas para impulsar desarrollo comercial y aumentar su competitividad empresarial.
Biogas Production in Laboratory Scale from Different Organic Wastes Using Primary Sludge as Co-substrate
Authors: Prifti Holta , Floqi Tania 
Published: February 2022

Biogas production technology not only constitutes a biofuel source, but also can be a mitigation measure for the various environmental pollutants. This technology, i.e., anaerobic digestion is a biological process that takes place naturally when microorganisms break down organic matter in the absence of oxygen. In an enclosed chamber, controlled anaerobic digestion of organic matter produces biogas which is predominantly methane. The produced methane then can be directly used; or after certain conditioning, can be used in onsite power generation, heating homes or as vehicular fuel. Besides, organic waste is increasingly becoming a major problem in every society imposing serious economic and environmental concerns. For this reason, many contemporary researches are emphasizing in finding sustainable solutions to recycle and produce energy from such waste. In this context, this paper aims to investigate the potential of cow and chicken manure, and olive waste for biogas production obtained through the anaerobic digestion process.
The substrates were placed in laboratory scale digesters without pretreatment. The retention time in the digesters was 30 days. The samples of the tested substrates were collected and analyzed for pH, total solids, ash, and the content of volatile solids (VS). Under mesophilic conditions, all combinations of cow and chicken manure, and olive waste with sludge by an anaerobic pond of a trickling filter treatment plant, as co-substrate, significantly improved biogas, and methane yields. The experimental results showed that chicken manure (CM) is the most suitable for anaerobic digestion (AD).
The next step of the study will consist in implementing a large scale of biogas production plants and we will estimate the national potential of green energy produced by this technology and map the areas that need digesters.
Hydraulic Modelling of Different Working Regimes in Water Pipeline. Case Study: Mihaliq – Water Treatment Plant “SHKABAJ”
Authors: Vataj Gjelosh , Berisha Xhevat , Sejfijaj Zenel 
Published: February 2022

In the flow through the pipes, we have unstable movements when, due to the closing or opening of the valve or other hydraulic equipment, the speed of movement of the liquid changes. The change in velocity causes inertial forces to arise in the liquid which cause pressure changes in the flow. The phenomenon characterized by these pressure changes is called hydraulic water hammer.
The hydraulic shock can be called the increase or decrease of the flow pressure in the pipe caused by the change in time (in any section) of the flow velocity.
The objective of this paper is to provide information and resources to assist water company management and their staff in identifying and implementing opportunities to reduce energy use. Case study is Pumping Station in Milloshevo managed by Regional Water Company “PRISHTINA”.
Potential Energy Production from Biogas Economically and Environmental Profitable. Case Study: Establishing a Batch Digester in “Fogi” Farm
Authors: Prifti Holta , Floqi Tania , Mico Mirel 
Published: February 2022

Recently the use of biomass for biogas production is very limited in Albania. According to data acquistion from the study, the highest share in the entire structure of urban solid waste is that of organic waste 41-61.2%.
A large part of these waste are bio digestible and can used for production or utilized as potential substrate in anaerobic digestion to produce biogas, a renewable source of energy and environment friendly too.
Live stocks waste and especially cow manure farms are concerned in this study because there are a high number 11813 of them are spread all over Albania. In addition, the amount of cow manure exceeds 37,693.92 ton/year.
In this case study is presented a cow farm located near Tirana, capital city of Albania with 200 cow heads which in the future will become 700 cow heads. The total amount of cow manure produced in this farm is 1825 ton/year, a considerable quantity of manure available for biogas production.
This paper presents the type of digester, calculation of the biogas production yield, the optained energy, the pay back period of the initial investment and the net present value of this farm batcher digestor.
Electrical Power Generation System: Optimal Design for Medium-Load Industries with High-Rated Generators
Authors: Soeb Md. Janibul Alam , Iqbal Md. Shahid , Mojumder Md. Abu Naser , Al Mamun Muhammad Rashed , Atik A. S. M. Shahjalal , Jubayer Md. Fahad 
Published: February 2022

The demand for electrical power is rapidly increasing due to the rise of industries in developing countries. Power generation stations are having troubles to strike a balance between demand and generation. In this situation, it is urged that appropriate remedial action be taken. Rising power demand can be met by designing an efficient electric power generation system which will also help lowering the generation cost. It is shown that while high rated electric power generators are connected in parallel the value of neutral current is rising and the cooling temperature is also increased. Here, the goal of this experimental work is to present a new model for designing an efficient power production system for average-load (ranging up to 8000 Amp, 440 V) industries to minimize the demand on centralized interconnected grid. A scheme is proposed with four generators (2500 kVA, 2000 kVA, 2000 kVA and 1250 KVA) in parallel and enough cooling arrangement is provided with minimal cost. The coolant temperature is maintained 61 °C to 61.5 °C and at that time diesel temperature is not more than 38.5 °C. The amount of neutral-current is also optimized (up to 8.5 Amp.) which was more than 12 Amp. At the morning and afternoon, the neutral current is almost constant, but it is bit fluctuating between 7.5 Amp to 8.2 Amp at mid-day. The final outcome shows, the suggested system is efficiently stable with the change of load and generates optimal electricity.
DAMPAK PENGGUNAAN SMARTPHONE TERHADAP INTERAKSI SOSIAL REMAJA DI DESA SEI SEMAYANG
Authors: Delani Aritonang Ika 
Published: February 2022

Penelitian ini bertujuan untuk (1) mendeskripsikan penggunaan smartphone dikalangan remaja di Desa Sei Semayang, (2) mendeskripsikan interaksi sosial remaja di Desa Sei Semayang, (3) mengetahui dampak penggunaan smartphone terhadap interaksi sosial remaja. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kuantitatif dengan sampel penelitian berjumlah 49 orang remaja yang diambil dengan random di Desa Sei Semayang. Alat yang digunakan pada teknik pengumpulan data adalah kuesioner, teknik analisis data yang digunakan adalah regresi linier sederhana dan uji t. Berdasarkan pengolahan data dengan regresi linier sederhana diperoleh persamaan regresi linier adalah Y= 49,916 + 0,608X, hasil uji hipotesis dengan uji t diperoleh nilai thitung > ttabel yaitu 4,769 > 1,684. Artinya terdapat dampak penggunaan smartphone terhadap interaksi sosial remaja di Desa Sei Semayang. Maka dapat disimpulkan bahwa semakin baik penggunaan smartphone maka akan semakin baik pula interaksi sosial tersebut.
Pengelolaan Keuangan dan Strategi Promosi pada UMKM Peci Batik Jogokariyan Yogyakarta
Authors: Cahya Agus Dwi , Suryadi Abdul Aziz , Evany Sherfina Tabatini 
Published: February 2022

This research deals with financial management and promotion strategies in UMKM. Here the researchers chose the “Peci Batik Jogokariyan” UMKM. The purpose of this research is to find out how the management is carried out by the UMKM “Peci Batik Jogokariyan” and how the promotion strategies are carried out. Good UMKM is UMKM that carry out good and correct financial management and UMKM that have efficient promotional strategies. Financial management and promotional strategies are essential for increasing UMKM sales and the future development of UMKM. However, some UMKM has not carried out good and correct financial management and there are still many UMKM that do not have an efficient promotion strategy so that it becomes an obstacle for the development of these UMKM. However, in this study, the researchers obtained the results of the interview that UMKM “Peci Batik Jogokariyan” already has good and correct financial reports and has carried out an efficient promotion strategy so that they can continue to develop for UMKM. The data technique uses documentation, interviews, and observations and this type of research is descriptive exploratory. Penelitian ini berkaitan dengan pengelolaan keuangan dan strategi promosi dalam UMKM. Di sini peneliti memilih UMKM “Peci Batik Jogokariyan”. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengelolaan yang dilakukan oleh UMKM “Peci Batik Jogokariyan” dan bagaimana strategi promosi yang dilakukan. UMKM yang baik adalah UMKM yang melakukan pengelolaan keuangan yang baik dan benar serta UMKM yang memiliki strategi promosi yang efisien. Pengelolaan keuangan dan strategi promosi merupakan hal yang penting bagi peningkatan penjualan UMKM serta perkembangan UMKM kedepannya. Namun beberapa UMKM belum melakukan pengelolaan keuangan yang baik dan benar serta masih banyak UMKM yang belum memiliki strategi promosi yang efisien sehingga itu menjadi kendala bagi perkembangan UMKM tersebut. Namun dalam penelitian ini, peneliti mendapatkan hasil wawancara bahwa UMKM Peci Batik Jogokariyan telah memiliki laporan keuangan yang baik dan benar serta telah melakukan strategi promosi yang efisien sehingga bisa terus melakukan perkembangan bagi UMKM. Teknik pengumpulan data dalam penelitian ini dengan dokumentasi, wawancara, dan observasi jenis penelitian ini eksploratif deskriptif.
Influence of Fundamental Factors to Share Price in Property, Real Estate, and Construction Companies
Authors: Kuswardani Faradiba Utari , Johan Suwinto 
Published: February 2022

In recent years there is a rapid growth in users or investors in the capital market. The rapid growth of technology is also one of many reasons investors can enter the capital market easily. This research was conducted to help the new investor in collecting important information about certain companies, especially Property, Real Estate, and Construction sectors. The objective of this research is to test and investigate the impact of Debt Ratio (D/R), Price Earnings Ratio (P/ER), and Return on Assets (ROA). This research is also to compare and improve the results of prior research. The sample used was Property, Real Estate, and Construction companies that passed the test of purposive sampling. Three years of data have been used (2017 to 2019). The Descriptive statistics and Normality found that the data were normally distributed with a random effect model to test the hypotheses. Regression results show that the Price Earning Ratio (P/ER) influences Market Price. While the Debt Ratio (D/R) and Return on Assets (ROA) of the companies were not influencing toward Market Price. Dalam beberapa tahun terakhir terjadi pertumbuhan yang pesat pada pengguna atau investor di pasar modal. Pertumbuhan teknologi yang pesat juga menjadi salah satu alasan investor dapat memasuki pasar modal dengan mudah. Penelitian ini dilakukan untuk membantu investor baru dalam mengumpulkan informasi penting tentang perusahaan tertentu khususnya sektor Properti, Real Estate dan Konstruksi. Penelitian ini bertujuan untuk menguji dan mengetahui pengaruh Debt Ratio (D/R), Price Earnings Ratio (P/ER) and Return on Assets (ROA). Penelitian ini juga untuk membandingkan dan menyempurnakan hasil penelitian sebelumnya. Sampel yang digunakan adalah perusahaan Properti, Real Estate dan Konstruksi yang lolos uji purposive sampling. Data tiga tahun telah digunakan (2017 hingga 2019). Statistik deskriptif dan normalitas menemukan bahwa data terdistribusi normal dengan model efek acak untuk menguji hipotesis. Hasil regresi menunjukkan bahwa Price Earning Ratio (P/ER) berpengaruh terhadap Harga Pasar. Sedangkan Debt Ratio (D/R) and Return on Assets (ROA) perusahaan tidak berpengaruh terhadap Harga Pasar