bluuebunny/crossref_metadata_2025_split huggingface dataset:
Raz and the Rule of (Authoritative) Law
Authors: Nye* Hillary 
Published: August 2022

AbstractIn this paper I bring together Joseph Raz’s work on authority and his work on the rule of law, arguing that his commitments about authority entail the conclusion that the rule of law is integral to the very nature of law. I take no position on whether Raz is right about the nature of law. Instead, I aim to mount an entirely internal critique of Raz’s work that will show that if Raz is right about authority, he is committed to a view about the rule of law which he has explicitly disavowed.
Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis
Authors: Campbell Bethany F. , Hercyk Brian S. , Williams Ashlei R. , San Miguel Ema , Young Haylee G. , Das Maitreyi E. 
Published: August 2022

AbstractFission yeast cytokinesis is driven by simultaneous septum synthesis, membrane furrowing and actomyosin ring constriction. The septum consists of a primary septum flanked by secondary septa. First, delivery of the glucan synthase Bgs1 and membrane vesicles initiate primary septum synthesis and furrowing. Next, Bgs4 is delivered for secondary septum formation. It is unclear how septum synthesis is coordinated with membrane furrowing. Cdc42 promotes delivery of Bgs1 but not Bgs4. We find that after primary septum initiation, Cdc42 inactivators Rga4 and Rga6 localize to the division site. In rga4Δrga6Δ mutants, Cdc42 activity is enhanced during late cytokinesis and cells take longer to separate. Electron micrographs of the division site in these mutants exhibit malformed septum with irregular membrane structures. These mutants have a larger division plane with enhanced Bgs1 delivery but fail to enhance accumulation of Bgs4 and several exocytic proteins. Additionally, these mutants show endocytic defects at the division site. This suggests that Cdc42 regulates primary septum formation and only certain membrane trafficking events. As cytokinesis progresses Rga4 and Rga6 localize to the division site to decrease Cdc42 activity to allow coupling of Cdc42‐independent membrane trafficking events with septum formation for proper septum morphology.
Failure mode effects and criticality analysis of water supply systems' risks: Path to water resources planning and policy
Authors: Odjegba Enovwo Erere , Oluwasanya Grace , Idowu Olufemi Abiola , Shittu Olufunke Bolatito 
Published: August 2022

AbstractThe risk assessment of drinking‐water supply systems in Ogun State, Nigeria, was carried out using the failure mode effects and criticality analysis (FMECA) approach. The FMECA is a systemic process that identifies potentials failure modes within a system and was chosen for its causes and effect approach to assessing risks. The objective of the study was to assess drinking‐water supply systems and identify water supply systems' risks from source to point‐of‐use. Three major water supply sources were selected for assessment: hand‐dug wells, boreholes and public water supply sources. The sources were assessed by identifying the potential failure modes that exist within the water supply sources and the consequence of the identified risks on relevant stakeholders. The sources were divided into modules. The risk in each module was determined by multiplying failure rate (likelihood) and consequences of failure of the module. Risk reduction options include repair and maintenance measures, information dissemination on the procedures to reduce the identified risks and preventive and regulatory approaches. The resulting risks were characterized using FMECA risk matrix of each water source and classified into high, medium and low risks. Well cover and lining were the most risk‐prone modules for hand‐dug wells (high and medium risks). Broken well cover and lining serve as pathways to contaminants into the well. Casing and screen modules posed the highest risk for boreholes, recording high to medium risk. Cracked casing and broken screen provide access for contamination into boreholes. The module with the greatest risk for public water supply source was the point‐of‐abstraction/use module. Unsanitary containers and poor storage conditions is believed to be responsible for recontamination of the treated water Climate variability, environmental and anthropogenic influences were observed to be responsible for most of the identified risks. The study highlights that consumer participation is vital in ensuring the availability of safe drinking‐water, stressing consumer education as the most important channel. The study recommends the use of FMECA to ensure implementing preventive and regulatory measures by water monitoring agencies and for water resources planning and policy making.
Experiences of adult patients living with depression-related insomnia: a qualitative systematic review protocol
Authors: Kristiansen Sanne T. , Videbech Poul , Kragh Mette , Sigaard Karen R. , Lyhne Cecilie N. , Larsen Erik R. , Bjerrum Merete 
Published: August 2022

Objective:
The objective of this review is to identify and synthesize the best available evidence on how adult patients experience living with depression-related insomnia. In particular, the review will examine the experiences related to pharmacological and non-pharmacological interventions to improve sleep.

Introduction:
Approximately 80% to 90% of patients with depression have insomnia, which is associated with substantial personal and social costs. Despite these costs, insomnia is often underdiagnosed and viewed as a symptom that disappears when depression abates. However, research indicates that insomnia and depression are overlapping but distinct disorders. Thus, it is important to treat both disorders simultaneously, as improving sleep may, in turn, ease core symptoms of depression. Optimal care and treatment rely on patients’ experiences of insomnia and their attitudes toward treatment options. Therefore, it is important to synthesize evidence of patients’ experiences of living with insomnia, and the experiences of pharmacological and non-pharmacological sleep interventions, to understand the consequences of insomnia and to optimize sleep interventions.

Inclusion criteria:
This systematic review will synthesize qualitative studies exploring how adults with depression experience living with insomnia and how they experience pharmacological or non-pharmacological sleep interventions. Both inpatient and outpatient populations will be considered.

Methods:
Databases to be searched include MEDLINE, Embase, CINAHL, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane CENTRAL, SveMed+, Scopus, and Web of Science Core Collection. Google Scholar and ProQuest Dissertations and Theses will be searched for unpublished studies. Studies in English, German, Danish, Swedish, and Norwegian will be included. Databases will be searched from their inception to the present date. All studies will be screened against the inclusion criteria and critically appraised for methodological quality. Findings will be pooled using meta-aggregation, and a ConQual Summary of Findings will be presented.

Systematic review registration number:
PROSPERO CRD42021276048
Methods of training lay individuals in the use of evidence-based services for the management of mental and behavioral health disorders: a scoping review protocol
Authors: Bagchi Ann D. , Hargwood Pamela , Saravana Arunadevi , DiBello Angelo M. , D’Alonzo Karen T. , Jadotte Yuri 
Published: August 2022

Objective:
The objective of this scoping review is to describe how lay individuals have been trained in evidence-based therapies to manage mental and behavioral health disorders as defined by the International Classification of Diseases, version 11.

Introduction:
Health service delivery by lay individuals is common in under-resourced areas. Prior systematic reviews have examined the characteristics of lay workers, the types of services they provide, and the efficacy of their services. Our goal is to focus on the methods of training.

Inclusion criteria:
Participants will include lay individuals who provide services to community residents; we will exclude individuals with formal training in health service delivery. We will consider for inclusion studies that include training programs for evidence-based therapies delivered to individuals with mental and behavioral health disorders, and will exclude those involving pharmacology or focusing on cognitive defects.

Methods:
We conducted a preliminary search of the literature on PubMed and CINAHL for articles related to the inclusion criteria and published in the past 10  years. Scanning the title, abstract, keywords, and MeSH terms, we generated comprehensive lists of terms and added search terms from 6 recent systematic reviews. Our search strategy will include MEDLINE, CINAHL, PsycINFO, Scopus, Web of Science, and gray literature. We will also consult with experts and review the reference lists of articles selected for final inclusion. Articles published in English or Spanish between 1960 and the present will be considered for inclusion. Data analysis will use a mix of descriptive and qualitative approaches, with data presented graphically or in diagrammatic or tabular format.
Incidence, prevalence, and timing of postpartum complications and mortality in Canada and the United States: a systematic review and meta-analysis protocol
Authors: Ke Janny Xue Chen , Vidler Marianne , Dol Justine , Carvalho Brendan , Blake Lindsay Ellis A. , George Ronald B. , Bone Jeff , Seligman Katherine M. , Coombs Micaela , Chau Anthony , Saville Laura , Gibbs Ronald S. , Sultan Pervez 
Published: August 2022

Abstract

Objective:
The goal of this systematic review is to assess the incidence, prevalence, and timing of common postpartum (up to 1 year after delivery) medical, surgical/procedural, and psychosocial complications and mortality.

Introduction:
Childbirth is the most common cause for hospitalization, and cesarean delivery is the most commonly performed inpatient surgery. After delivery, mothers are at risk of short- and long-term complications that can impact their well-being. The results of this review will inform evidence-based recommendations for patient education, monitoring, and follow-up.

Inclusion criteria:
We will include studies performed in Canada and/or the United States that report the incidence or prevalence of medical, procedural/surgical, and psychosocial complications within 1 year postpartum. Observational studies (analytical cross-sectional studies, retrospective and prospective cohorts), randomized or non-randomized controlled trials with a control or standard of care group, systematic reviews, and meta-analyses will be included. Studies with fewer than 100 patients, participants younger than 18 years, no reporting of duration, or focus on patients with a specific condition rather than a general postpartum population will be excluded.

Methods:
The search strategy was codeveloped with a medical librarian and included full-text English-language articles published within the past 10 years (2011–2021) in PubMed, CINHAL, Web of Science, and Cochrane Database of Systematic Reviews. Screening, critical appraisal, and data extraction will be performed by two independent reviewers using Covidence, standardized JBI tools, and a standardized form, respectively. For each complication, the incidence or prevalence, timing of the frequency measurement, and duration of follow-up from individual studies will be determined. Meta-analysis will be performed if feasible.

Systematic review registration number:
PROSPERO CRD42022303047
A Web-Based Collaborative Method for SysML Modeling
Authors: Xing Tao , Zhou Chenchu , Shen Xing , Wu Dawei , Li Qian , Liu Yusheng 
Published: August 2022

Abstract
Model-based systems engineering (MBSE) with SysML has become one of the best solutions to the system design of complex systems, which usually requires the collaboration of different disciplines. Web-based collaborative modeling method looks like a prioritized option because of its advantages such as “light” client, convenient maintenance, and high model reliability. In this study, we propose a web-based collaborative SysML modeling method for MBSE. First, the architectures of asynchronous and synchronous collaboration are given. Then, some key technologies for both collaborative modes are discussed. Finally, a case study is given to demonstrate the effectiveness of the proposed method.
A NURBS Curve Interpolator Based on Double-Step Signal and Finite Impulse Response Filters
Authors: Zhang Tie , Guo Liangliang , Zou Yanbiao 
Published: August 2022

Abstract
In order to solve the problem that the traditional trajectory planning method cannot flexibly control the velocities and the arrival time of critical points in the trajectory, this paper proposes a non-uniform rational B-spline interpolator based on double-step signal and finite impulse response filters. The interpolator consists of two modules: a pre-processing module and a real-time interpolation module. To reduce the contour error, first, the pre-processing module scans the curve for critical points and sets their velocities according to the chord error. Then, the curve is split, and for each segment, the length and inverse length functions are calculated to eliminate the length error and enhance the real-time performance. Moreover, to control the arrival time and smooth the velocity, the real-time interpolation module generates the trajectory by processing the double-step signal with three finite impulse response filters, which satisfies the constraints of velocity, acceleration, jerk, and displacement. Simulation results indicate that the proposed interpolator can accurately reach the critical points at the set arrival time with smooth velocity and low chord error, and experimental results on a SCARA robot show that the proposed interpolator is feasible and effective.
Multiphase Flow Field Analysis and Experimental Study of Pulsating Air Jet Polishing
Authors: Zhang Lei , Ding Chen , Wang Zhao , Fan Cheng 
Published: August 2022

Abstract
Aiming at the shortcomings of the existing fluid polishing methods such as low abrasive utilization rate and high equipment energy consumption, a new method of pulsating air jet polishing (PAJP) is proposed in this article. In this article, the force on the abrasive in the turbulent state is analyzed based on the micro model of near-wall flow field. Based on the realizable k-ɛ turbulence model and mixture multiphase model, the gas–liquid–solid flow field is simulated numerically. The numerical simulation results reveal the variation law of the velocity field and the pressure field inside the flow field, and the accuracy of the simulation model has been verified by polishing experiments. The effects of jet pressure, jet angle, jet distance, and abrasive concentration on the removal depth and surface roughness of titanium alloys are analyzed by a combination of simulation and experiment, and the process parameters of PAJP are optimized.
Numerical Modeling and Design Challenges of Boundary Layer Ingesting Fans
Authors: Sieradzki Adam , Kwiatkowski Tomasz , Turner Mark G. , Łukasik Borys 
Published: August 2022

Abstract
Studies show that boundary layer ingesting (BLI) propulsion can provide significant fuel burn reduction relative to pylon-mounted turbofan engines. However, this type of propulsion can lead to serious difficulties and engineering challenges. Numerical analyses of the fan with a uniform flow at the inlet and that exposed to the distorted flow were performed. These required the use of a full-annulus unsteady time-marching computational fluid dynamics (CFD) model, which was validated with experimental data obtained at a test rig. The first negative effect of the distorted inlet velocity profile is a variable incidence angle of the rotor. Both the calculations and the experiment show the nonuniform axial and tangential velocity profiles in front of the rotor. As a result, significant changes in the angle of attack of the blades and corresponding unsteady rotor loads are observed. The research was performed for different operating conditions to obtain performance curves and assess the BLI influence. This demonstrated the second problem arising from the operation of the fan with the distorted flow at the inlet, which is a reduction of the stall margin (48% reduction in the experiment). The whole stage was optimized for the axisymmetric flow to ensure a required value of stall margin and the highest possible efficiency at the design point. The experimental efficiency of the rig at the design point with the distorted inlet was 2.05% lower than the undistorted one. The CFD model shows a 1.25% reduction. Similar reductions were obtained for other operating points.
Sensitivity of Adiabatic Cooling Effectiveness to Mainstream and Coolant Temperatures in Transonic Flow Over an Idealized Blade Tip Model
Authors: Ma Haiteng , Zeng Wei , Dai Siming , Jiang Hongmei 
Published: August 2022

Abstract
Film cooling, as a key technology to ensure turbine survival in new generation gas turbines, has been studied profusely in subsonic flows. But in transonic flow, the determination of adiabatic cooling effectiveness faces a dilemma in the state of the art. Specifically, derivation of reference temperature, or local recovery temperature, in adiabatic effectiveness is disputable. Some researchers designate it to be the adiabatic wall temperature for the uncooled model (linear regression method (LRM)), but others calculate it from an iterative procedure based on a pair of cooling tests (dual linear regression technique (DLRT)). As the first of the kind effort to explore this dilemma, this article carried out transient thermal measurements by infrared thermography, for transonic flow over an idealized blade tip model. Heat transfer experiments were conducted for the uncooled and cooled cases, at two mainstream temperatures of 340 K and 325 K and two coolant temperatures of 276 K and 287 K. Data from these six experimental groups were processed by LRM and DLRT, respectively, to obtain heat transfer coefficient and adiabatic effectiveness, whose sensitivity to mainstream and coolant temperatures is tested and compared. It is found that the heat transfer coefficient is basically insensitive to temperature boundary conditions and data reduction methods, as expected. However, for adiabatic effectiveness, LRM results are sensitive to the 11 K decrease of coolant temperature in areas confined to the upstream of cooling injection, and much less so to the 15 K rise in mainstream temperature. DLRT result, derived from the test pair with two coolant temperatures, reduces globally and conspicuously with 15 K increase in mainstream temperature. Furthermore, adiabatic effectiveness obtained by LRM is qualitatively different from that by DLRT, which is mainly attributed to the large discrepancy in reference temperature between the two methods.
Reconstructing a dismembered Neogene basin along the active Hikurangi subduction margin, New Zealand
Authors: Hines Benjamin R. , Seebeck Hannu , Crampton James S. , Bland Kyle J. , Strogen Dominic P. 
Published: August 2022

AbstractThe East Coast Basin (ECB), New Zealand, preserves the most complete onshore stratigraphic record of the Cretaceous–Neogene development of Zealandia from Gondwana breakup, through rift-drift, to evolution of the modern Hikurangi subduction margin and Pacific-Australia plate boundary. As such, it provides important constraints for southwest Pacific plate tectonic reconstructions. The basin is, however, deformed and variably dismembered, and in previous tectonic models it has been treated as a zone of poorly constrained deformation. Here, multiple geological and geophysical data sets are integrated with a tectonic reconstruction to provide a synthesis of regional and intrabasin-scale structural evolution of the ECB during the Neogene, producing a new geologically constrained approach toward qualitative and quantitative assessment of deformation across the New Zealand plate boundary zone. We produce the first palinspastic reconstructions for the entire basin during key times in plate boundary development, within a well-constrained plate-tectonic framework, supported by independent deformation estimates. These reconstructions account for contraction, strike-slip, and vertical-axis rotation of crustal blocks. In the context of the reconstruction model, the ECB has dominantly experienced upper-plate shortening and vertical-axis rotations; strike-slip processes are considered comparatively minor. Comparison of the reconstruction model with independent data highlight several pronounced deformation intervals (26–23 Ma, 20–15 Ma, 11 Ma, and 7–4 Ma) in the structural and sedimentary evolution of the ECB, Hikurangi subduction margin, and New Zealand plate boundary zone, demonstrating that it is possible to integrate a wide range of geological data sets to develop meaningful reconstructions in highly tectonised regions.
Availability, scope and quality of monkeypox clinical management guidelines globally: a systematic review
Authors: Webb Eika , Rigby Ishmeala , Michelen Melina , Dagens Andrew , Cheng Vincent , Rojek Amanda M , Dahmash Dania , Khader Susan , Gedela Keerti , Norton Alice , Cevik Muge , Cai Erhui , Harriss Eli , Lipworth Samuel , Nartowski Robert , Groves Helen , Hart Peter , Blumberg Lucille , Fletcher Tom , Jacob Shevin T , Sigfrid Louise , Horby Peter W 
Published: August 2022

BackgroundMonkeypox (MPX) is an important human Orthopoxvirus infection. There has been an increase in MPX cases and outbreaks in endemic and non-endemic regions in recent decades. We appraised the availability, scope, quality and inclusivity of clinical management guidelines for MPX globally.MethodsFor this systematic review, we searched six databases from inception until 14 October 2021, augmented by a grey literature search until 17 May 2022. MPX guidelines providing treatment and supportive care recommendations were included, with no exclusions for language. Two reviewers assessed the guidelines. Quality was assessed using the Appraisal of Guidelines for Research and Evaluation II tool.ResultsOf 2026 records screened, 14 guidelines were included. Overall, most guidelines were of low-quality with a median score of 2 out of 7 (range: 1–7), lacked detail and covered a narrow range of topics. Most guidelines focused on adults, five (36%) provided some advice for children, three (21%) for pregnant women and three (21%) for people living with HIV. Treatment guidance was mostly limited to advice on antivirals; seven guidelines advised cidofovir (four specified for severe MPX only); 29% (4/14) tecovirimat, and 7% (1/14) brincidofovir. Only one guideline provided recommendations on supportive care and treatment of complications. All guidelines recommended vaccination as post-exposure prophylaxis (PEP). Three guidelines advised on vaccinia immune globulin as PEP for severe cases in people with immunosuppression.ConclusionOur results highlight a lack of evidence-based clinical management guidelines for MPX globally. There is a clear and urgent need for research into treatment and prophylaxis including for different risk populations. The current outbreak provides an opportunity to accelerate this research through coordinated high-quality studies. New evidence should be incorporated into globally accessible guidelines, to benefit patient and epidemic outcomes. A ‘living guideline’ framework is recommended.PROSPERO registration numberCRD42020167361.