bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Geogebra Pada Materi Bangun Datar bagi Guru Matematika Sekolah Menengah Pertama di Kec. Wonomulyo
Authors: Ansar Ahmad , Asrirawan  
Published: September 2022

Media pembelajaran matematika dirancang untuk meningkatkan efektivitas dan efisiensi proses belajar mengajar. Pembuatan media pembelajaran matematika berbantuan aplikasi sangat cocok menggunakan geogebra. Oleh karena itu, dirancang suatu kegiatan yang mampu memberikan pemahaman dalam menggunakan aplikasi geogebra dalam membuat media pembelajaran. Tujuan kegiatan pengabdian kepada masyarakat ini adalah memperkenalkan aplikasi Geogebra untuk membantu pembelajaran matematika serta untuk meningkatkan keterampilan guru dalam membuat dan mengembangkan media pembelajaran matematika dengan visualisasi yang menarik. Kegiatan pengabdian ini dilakukan di SMP Negeri 5 Wonomulyo dan diikuti oleh 9 guru dari berbagai sekolah di Kec. Wonomulyo. Pelaksanaan pengabdian kepada masyarakat dilakaukan dalam empat tahap kegiatan yaitu tahap awal, tahap persiapan, tahap pelaksanaan dan tahap evaluasi. Hasil yang diperoleh berupa peningkatan kemampuan guru matematika dalam menggunakan geogebra dan membuat media pembelajaran materi bangun datar.
Pelatihan dan Pendampingan Menggunakan Dasar- Dasar Aplikasi Mendeley
Authors: Sudirman Andi Mangnguntungi , Irmayani Irmayani , Suardi Suardi , Upa Rahmawati , Darmawansyah Alif 
Published: September 2022

Penulisan ilmiah dilakukan dengan berdasarkan referensi kepustakaan. Seluruh sumber yang digunakan perlu diberi kutipan atau disitasi dan kemudian sumber yang dikutip tersebut dicantumkan dalam daftar pustaka atau referensi. Pengutipan sumber dalam tulisan dan pencantuman dalam daftar pustaka disebut gaya sitasi. Suatu sitasi (citation) atau bibliographic citation adalah suatu rujukan terhadap . buku, artikel, halaman web, atau produk-produk hasil penerbitan lainnya yang memberikan cukup rincian untuk mengidentifikasi produk penerbitan itu secara unik. Penulisan kutipan tidak lepas dari kegiatan para akademisi khususnya mahasiswa. Hal tersebut ditemukan pada penyusunan tugas akhir. Penulisan Skripsi sangat erat kaitannya dengan penggunaan citation atau kutipan. Kegiatan pelatihan pengoperasian mendeley ini dilaksanakan selama tiga hari yang dihadiri oleh Mahasisswa Universitas Cokroaminoto Palopo dari Program Studi Pendidikan Bahasa Inggris di ruang E8. Materi yang disampaikan berupa tatacara membuat akun Mendeley, instalasi aplikasi Mendeley, mendownload jurnal bereputasi sesuai bidnag ilmu masing-masing, pemanfaatan tools pada aplikasi Mendeley, serta tata cara penulisan kutipan dengan beragam style. Sekitar 90% dari peserta pelatihan tersebut telah mahir menggunakan aplikasi Mendeley dengan tools yang dimiliki serta telah dapat mengakses jurnal bereputasi sesuai dengan bidang ilmu masing-masing peserta.
PENERAPAN MODEL PEMBELAJARAN PBL (PROBLEM BASED LEARNING) UNTUK MENINGKATKAN HASIL BELAJAR KOGNITIF KIMIA PESERTA DIDIK PADA MATERI STRUKTUR ATOM KELAS X 3 SMA OIKOUMENE MANOKWARI
Authors: Hapsari Ceyza Dinda , Ramlah Ramlah 
Published: September 2022

AbstractThis study aims to improve student learning outcomes in class X 3 SMA OIKOUMENE Manokwari by using the PBL learning model on the atomic structure material. This study used a collaborative classroom action research method with a chemistry teacher for two cycles, each cycle consisting of two meetings. One meeting includes the stages of planning, implementation, observation and reflection. The results showed that the PBL (Problem Based Learning) model could improve the cognitive learning outcomes of X 3 grade students at SMA OIKOUMNE Manokwari. This is indicated by the final data acquisition that in the first and second cycles the first and second meetings each obtained an average score of 41.6666 and 60.4166 which increased in the second cycle at the third and fourth meetings to 76.25 and 83.3333 with student completeness reach100%. Keywords: Problem Based Learning, Learning Results, Atomic Structure, Class Action Research, Oikoumene High School
Peran Keluarga Terhadap Kepatuhan Remaja Menerapkan Protokol Kesehatan
Authors: Pratiwi Wilda Rezki , Hasriani Siti , Asnuddin Asnuddin 
Published: September 2022

Wabah Covid-19 merupakan jenis penyakit baru dan sangat mudah menular yang mengubah berbagai gaya hidup masyarakat. Salah satu upaya perlindungan kesehatan yang dapat dilakukan yaitu dengan menggunakan alat pelindung diri (APD), membersihkan tangan, jaga jarak dan meningkatkan daya tahan tubuh. keluarga memiliki peran penting dalam mendukung kebijakan pemerintah untuk perubahan perilaku. Untuk menganalisis peran keluarga terhadap kepatuhan remaja menerapkan protokal kesehatan. Metode yang digunakan dalam penelitian ini adalah metode penelitian observasional analitik dengan rancangan Cross Sectional Populasi sebanyak 98 orang. Sampel : 72 orang. Penentuan teknik pengampilan sampel menggunakan cluster random sampling. Adapun kriteria yang menjadi sampel dalam penelitian ini yaitu anak yang berusia 10- 19 tahun, tinggal bersama orang tua, bersedia menjadi responden penelitian. Responden akan diberikan kuisioner yang sudah uji validasi dan reliabilitasnya, selanjutnya akan di uji statistic Chi Square. Teknik analisa data menggunakan Chi-Square. Hasil: Uji Chi Square antara variabel yang diteliti nilai sig (2- tailed) 0,010 yang artinya terdapat pengaruh peran orang tua terhadap kepatuhan remaja. Simpulan: Diharapkan keluarga sebagai bagian terkecil dari masyarakat dapat mengambil peran aktif dalam menghadapi persoalan Covid-19 yang dapat dilakukan adalah mampu mendisiplikan seluruh anggota keluarganya serta melakukan edukasi atau mendidik anak – anaknya supaya mematuhi protokol kesehatan yang ditetapkan oleh pemerintah.
Kata Kunci : Peran keluarga, Remaja, Protokol Kesehatan
Development of an Algorithm to Screen for Frailty Using the Clinical Frailty Scale with Postoperative Patients Entering Cardiac Rehabilitation
Authors: Rashid Coomal , Pollock Courtney , Aldworth Madeleine , Chow Jennifer , Kent Michael , Sapardanis Kristina , Yentin Sam , Jaglal Susan , Colella Tracey JF 
Published: September 2022

Purpose: Frailty is not commonly assessed on intake to cardiac rehabilitation (CR), but screening could enable targeted interventions and potentially reduce secondary complications. This study aimed to develop and retrospectively examine the feasibility of utilizing a CR-specific algorithm based on the Clinical Frailty Scale (CFS). Our CFS-CR algorithm endeavoured to screen for frailty in older adults (> 65 y) entering CR following cardiac surgery/procedure. Method: The charts of 30 former patients (mean age: 74.0 ± 6.9 y) were examined by a clinician working in CR. Results: The clinician was unable to score any of the patients based on their medical charts using the CFS-CR due to insufficient data. Documentation was typically limited in the areas of instrumental and basic activities of daily living whereas exercise data were readily available. Conclusions: Current intake documentation in CR limited the ability to retrospectively screen for frailty. This finding suggests a need for a frailty-specific tool to support routine clinical screening. Prospective evaluation of the CFS-CR is warranted to further examine the clinical utility of the algorithm during CR intake assessments.
PENGEMBANGAN INSTRUMEN PENILAIAN BERBASIS GOOGLE FORM SEBAGAI ALTERNATIF PENILAIAN HASIL BELAJAR KOGNITIF PADA MATERI SISTEM SIRKULASI DI KELAS XI IPA JENJANG SEKOLAH MENENGAH ATAS/ MADRASAH ALIYAH (SMA/MA)
Authors: Nurhidayah Nurhidayah , M. Irfan  , Masriani  
Published: September 2022

Abstrak

Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk menghasilkan instrumen penilaian berbasis google form sebagai media penilaian biologi yang valid, praktis dan efektif. Penelitian pengembangan ini mengadaptasi model 4-D oleh Thiagarajan dengan urutan tahapan yaitu pendefinisian, perancangan, pengembangan, dan penyebaran. Desain awal draf divalidasi oleh ahli dan mengalami revisi kemudian dianalisis. Selanjutnya dilakukan uji terbatas di MAN 1 Polewali Mandar Kelas XI IPA 1 yang berjumlah 36 peserta didik. Data dikumpulkan dengan observasi, wawancara, angket dan tes. Hasil penelitian: (1) Validitas instrumen penilaian berbasis google form dari segi media 98% dan dari segi materi 95% merupakan kategori sangat valid. (2) Penelitian pengembangan mengenai instrumen penilaian berbasis google form diperoleh data nilai kepraktisan melalui angket respon guru sebesar 92% dan data dari angket respon peserta didik diperoleh data nilai kepraktisan sebesar 87% yang termasuk dalam kategori sangat praktis. (3) Efektivitas produk dari penelitian pengembangan mengenai instrumen penilaian berbasis google form termasuk kedalam kategori efektif dengan persentase keefektifam sebesar 66,6% yang diketahui melalui tes hasil belajar siswa. Jadi dapat disimpulkan bahwa instrumen penilaian hasil belajar kognitif berbasis google form telah memenuhi kategori valid, praktis dan efektif.

Kata Kunci: penelitian pengembangan, google form, instrumen penilaian
CONSTRAINTS TO YAM (DIOSCOREA SPP) PRICE FORMATION IN THE URBAN AND RURAL MARKETS OF THE CENTRAL AGRICULTURAL ZONE OF NASARAWA STATE, NIGERIA
Authors: IROEGBUTE U. K. , MOHAMMED I , JIBRIL S.A. 
Published: September 2022

Price formation of yam in the urban and rural markets of the Western agricultural zone of Nassarawa State, Nigeria has been an issue as many factors has been found to be contributing factors in the formation of yam price in the study area. Well-structured questionnaire was used to source for data from 141 hundred randomly selected yam marketers from the urban and rural markets in the zone, the rural markets were Andaha, Anguwan Zaria, Sabon Gida and Gudi while the urban markets includes Garaku, Akwanga, Nassarawa Eggon and Wamba. Descriptive statistic such as frequency, mean, and percentages was used to analyze the data. The result obtained revealed that majority (60%) and (62.5%) were male in the urban and rural markets respectively, with the mean ages of 47 years and 43.9 years respectively. The mean household size was 7 and 6 members for the urban and the rural households respectively. The average yam prices in ₦/kg in the urban /rural markets shows that the highest price was recorded in the urban market (Nassarawa Eggon) and the least price recorded in the rural market (Andaha), the Jarque-Bera test of normality shows that the prices of yam were normally distributed, of all the constraints to yam price formation, poor feeder roads, few number of buyers ranked most in the urban while poor feeder roads, and inadequate access to credit facilities ranked topmost in rural markets. Therefore the research suggests a deliberate government policy towards rehabilitation of roads linking the rural and urban markets, and this may enhance trade between urban and rural markets.
Polydopamine encapsulated new indocyanine green theranostic nanoparticles for enhanced photothermal therapy in cervical cancer HeLa cells
Authors: Fan Huimin , Yan Ting , Chen Shuang , Du Zhong , Alimu Gulinigaer , Zhu Lijun , Ma Rong , Tang Xiaohui , Heng Youqiang , Alifu Nuernisha , Zhang Xueliang 
Published: September 2022

Photothermal therapy (PTT) has attracted extensive attention in cancer treatment due to its non-invasiveness, high efficiency, and repeatability in recent years. Photothermal agents (PTAs) are the key factor for PTT. Recently, although an increasing number of PTAs have been developed, there is still a great demand for optimized photothermal nanoparticles (NPs) with low toxicity, bio-safety and stability. Herein, new indocyanine green (IR820) with near-infrared (NIR:700–1,700 nm) fluorescence emission was selected as a photothermal agent (PTA). To enhance the PTT property, IR820 was encapsulated with another kind of PTA, polydopamine (PDA) under alkaline conditions. Furthermore, to improve the biocompatibility of the NPs, methoxy polyethylene glycol amine (mPEG-NH2) was modified via a Michael addition to form a novel kind of IR820@PDA@PEG NPs. After detailed characterization and analysis, the obtained IR820@PDA@PEG NPs showed a spherical shape with an average diameter of ∼159.6 nm. Meanwhile, the formed IR820@PDA@PEG NPs exhibited better photostability and lower cytotoxicity than free IR820 molecules. The photothermal performance of IR820@PDA@PEG NPs was further analyzed in vitro, and the temperature of IR820@PDA@PEG NPs (100 μg/ml) reached 54.8°C under 793 nm laser irradiation. Afterwards, the cellular uptake of IR820@PDA@PEG NPs was evaluated via confocal laser scanning fluorescence microscopic imaging. Then, PTT experiments on HeLa cells demonstrated that IR820@PDA@PEG NPs can hyperthermal ablate cancer cells (∼49.1%) under 793 nm laser irradiation. Therefore, IR820@PDA@PEG NPs would be a promising PTA for the treatment of cervical cancer HeLa cells.
QEMSCAN® automated mineralogical analysis of PM2.5 and PM4: A preliminary study of underground coal mine dust from Poland and Slovenia
Authors: Johnson Diane , Rollinson Gavyn. K. , Arif Ali Talib , Moreno Teresa , Ruiz Pedro Trechera , Lah Robert , Lubosik Zbigniew , Pindel Thomas , Gminsk Richard , Williamson Ben J. 
Published: September 2022

Determining the physical and chemical properties of airborne dusts in occupational settings is essential for assessing their potential toxicity as well as the effectiveness of respiratory protective equipment and dust mitigation measures. Here, we report the first successful QEMSCAN® automated mineralogical analysis of potentially toxic PM4 and PM2.5 dust from deep coal mines in Poland and Slovenia. QEMSCAN® was setup to automatically delimit 100,000 ‘particles’ per sample, based on average atomic number contrast, subject these to X-ray elemental analysis at points in a grid pattern (0.5 µm spacing), assign a mineral name to each point and then output the results as particle size, shape, mineralogy and mineral associations data and as mineral maps. The dusts were prepared as dispersions on a polyethylene sheet so that coal particles, with a slightly higher BSE signal, could be recognized from their substrate. Samples were analyzed repeatedly and in different orientations to determine the effects of sample geometry and topography. QEMSCAN® mineral identifications were manually checked using standard SEM X-ray elemental analysis. From a pilot study of Polish and Slovenian coal dust samples, PM4 and PM2.5 contain varying proportions of coal, quartz and other silicates, sulphides, sulphates, carbonates, oxides and other minerals, and notable concentrations of fly-ash particles. That some of these components may be toxic when inhaled, particularly the quartz and fly-ash, highlights the need for larger scale and wider ranging studies. The further potential of the newly developed QEMSCAN® methodology is discussed.
Formation of calcium chloride brines in volcaniclastic-rich sediments
Authors: Sena Clara , Parkhurst David L. , Tepley ||| Frank J. , Jiang Fuqing , van der Land Cees , Coelho Francisco JRC , Oliveira Vanessa , Lever Mark A. , Ishizuka Osamu , Arculus Richard 
Published: September 2022

The Amami-Sankaku Basin, located in the Philippine Sea, records approximately 50 million years of sediment accumulation and diagenesis of volcanic ash derived from the Kyushu-Palau and Kyushu-Ryukyu arcs. Analyses of porewater and sediment samples from the 1461-m core recovered at IODP Expedition 351, Site U1438, included major and trace elements, strontium radiogenic isotope ratio (87Sr/86Sr), and taxonomic identification of archaeal classes and bacterial orders. Sediment X-ray diffraction and thin section analyses show that smectite, zeolites and chlorite are the main authigenic minerals. A multicomponent solute diffusion and reaction numerical model was developed to simulate the long-term diagenesis that took place in this sedimentary sequence and to account for the transition to a calcium chloride brine at about 670 mbsf. Numerical results indicate that 45% of the initial amount of volcanic ash has been dissolved at 750 mbsf. At this depth, 13% of the initial water (H2O) in the pore space is estimated to have been transferred to the solid phase by the formation of zeolites, which accounts for an increase in porewater chloride concentration. In contrast, dissolution of anorthite and volcanic ash combined with sodium uptake by zeolites accounts for the predominance of calcium in the brine. In the upper 160 m of the sedimentary column, the electrochemical migration of solutes causes chloride to move in the opposite direction of the concentration gradient, i.e., uphill diffusion, sustaining downward diffusion of seawater chloride into the sediments.
A novel prognostic 6-gene signature for osteoporosis
Authors: Zhao Yu , Yan Jieping , Zhu Yimiao , Han Zhenping , Li Tingting , Wang Lijuan 
Published: September 2022

IntroductionThe incidence of osteoporosis (OP) keeps increasing due to global aging of the population. Therefore, identifying the diagnostic and prognostic biomarkers of OP is of great significance.MethodsmRNA data from OP and non-OP samples were obtained from GEO database, which were divided into training set (GSE35959) and testing sets (GSE7158, GSE62402, GSE7429 and GSE56815). Gene modules most significantly related to OP were revealed using weighted gene co-expression network analysis (WGCNA) and differentially expressed genes (DEGs) between OP and normal samples in training set were identified using limma R package. Thereafter, above two gene sets were intersected to obtain the genes potentially related to OP. Protein-protein interaction (PPI) pairs were screened by STRING database and visualized using Cytoscape, while the plug-in cytoHubba was used to screen hub genes by determining their topological parameters. Afterwards, a diagnostic model was constructed using those hub genes, whose creditability was further evaluated by testing sets.ResultsThe results of WGCNA analysis found the Black module was most significantly related to OP, which included altogether 1286 genes. Meanwhile, 2771 DEGs were discovered between OP patients and the normal controls. After taking the intersection, 479 genes were identified potentially correlated with the development of OP. Subsequently, six hub genes were discovered through PPI network construction and node topological analysis. Finally, we constructed a support vector machine model based on these six genes, which can accurately classified training and testing set samples into OP and normal groups.ConclusionOur current study constructed a six hub genes-based diagnostic model for OP. Our findings may shed some light on the research of the early diagnosis for OP and had certain practical significance.
Genetic variant of ADH1C for predicting survival in esophageal squamous cell cancer patients who underwent postoperative radiotherapy
Authors: Xu Xin , Sun Zhiyong , Rong Ling , Wang Xiaohang , Xu Lei , Lu Jun , Ye Qing , Zhang Lei , Bai Yongrui , Ma Xiumei 
Published: September 2022

Background: Single nucleotide polymorphisms (SNPs) of essential enzymes for alcohol metabolism ADH1B, ADH1C, and ALDH2 are commonly regarded as genetic biomarkers for esophageal squamous cell carcinoma (ESCC) susceptibility. However, there have not been any reports on relations between SNPs of these genes and the prognosis of postoperative radiotherapy in ESCC. The current study aimed to understand the associations between gene variants of alcohol metabolism and adjuvant radiotherapy’s prognosis in ESCC.Methods: This study retrospectively analyzed 110 ESCC patients from our institution who received adjuvant radiotherapy after surgery. The SNPs of ADH1B rs1229984, ADH1C rs1789924, and ALDH2 rs671 were detected by Sanger sequencing using formalin-fixed paraffin-embedded tumor samples. A nomogram was drawn based on prognostic factors associated with overall survival (OS).Results: ADH1C rs1789924 (C&gt;T) was associated with poor DFS and OS in ESCC patients undergoing adjuvant radiotherapy. Multivariate analysis showed that ADH1C rs1789924 (C&gt;T) was one of the independent prognosis factors of DFS and OS. However, the genotypes of ADH1B SNP rs1229984 and ALDH2 rs671 were not associated with differences in the PFS and OS of these patients. Compared with the AJCC staging system, the nomogram containing the ADH1C genotype can more effectively and accurately predict the survival time of ESCC after surgery and adjuvant radiotherapy.Conclusion: ADH1C rs1789924 might be a prognostic genetic biomarker for ESCC patients undergoing surgery and postoperative radiotherapy.
The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation – Data from the Swiss transplant cohort study
Authors: Frischknecht Lukas , Deng Yun , Wehmeier Caroline , de Rougemont Olivier , Villard Jean , Ferrari-Lacraz Sylvie , Golshayan Déla , Gannagé Monique , Binet Isabelle , Wirthmueller Urs , Sidler Daniel , Schachtner Thomas , Schaub Stefan , Nilsson Jakob ,   the Swiss Transplant Cohort Study
Published: September 2022

BackgroundPre-transplant donor specific antibodies (DSA), directed at non-self human leukocyte antigen (HLA) protein variants present in the donor organ, have been associated with worse outcomes in kidney transplantation. The impact of the mean fluorescence intensity (MFI) and the target HLA antigen of the detected DSA has, however, not been conclusively studied in a large cohort with a complete virtual cross-match (vXM).MethodsWe investigated the effect of pre-transplant DSA on the risk of antibody-mediated rejection (ABMR), graft loss, and the rate of eGFR decline in 411 DSA positive transplants and 1804 DSA negative controls.ResultsPre-transplant DSA were associated with a significantly increased risk of ABMR, graft loss, and accelerated eGFR decline. DSA directed at Class I and Class II HLA antigens were strongly associated with increased risk of ABMR, but only DSA directed at Class II associated with graft loss. DSA MFI markedly affected outcome, and Class II DSA were associated with ABMR already at 500-1000 MFI, whereas Class I DSA did not affect outcome at similar low MFI values. Furthermore, isolated DSA against HLA-DP carried comparable risks for ABMR, accelerated eGFR decline, and graft loss as DSA against HLA-DR.ConclusionOur results have important implications for the construction and optimization of vXM algorithms used within organ allocation systems. Our data suggest that both the HLA antigen target of the detected DSA as well as the cumulative MFI should be considered and that different MFI cut-offs could be considered for Class I and Class II directed DSA.