bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Androgen Receptor Modulator–Induced Liver Injury in Active Duty Male
Authors: Lee Byung K , Park Brian B , Bower Richard J 
Published: March 2022

ABSTRACT
Selective androgenic receptor modulators (SARMs) are extensively advertised as safer and more effective analogues to traditional androgenic anabolic steroids, yet there are increasing cases of hepatotoxicity secondary to their use. We present the case of a previously healthy young active duty Marine who presented with cholestatic liver injury secondary to SARM use. This is the first reported case in a service member and contributes to the growing amount of evidence regarding the potential detrimental effects of SARMs. It also illustrates the impact of SARMs on military members and overall mission readiness as his treatment course included hospitalization and placement in a non-deployable status until recovery from his liver injury. Additional steps should be taken to increase awareness in order to protect service members and sustain readiness.
Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor
Authors: Warwick Timothy , Schulz Marcel H , Gilsbach Ralf , Brandes Ralf P , Seuter Sabine 
Published: March 2022

Abstract
Spatial genome organization is tightly controlled by several regulatory mechanisms and is essential for gene expression control. Nuclear receptors are ligand-activated transcription factors that modulate physiological and pathophysiological processes and are primary pharmacological targets. DNA binding of the important loop-forming insulator protein CCCTC-binding factor (CTCF) was modulated by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). We performed CTCF HiChIP assays to produce the first genome-wide dataset of CTCF long-range interactions in 1,25(OH)2D3-treated cells, and to determine whether dynamic changes of spatial chromatin interactions are essential for fine-tuning of nuclear receptor signaling. We detected changes in 3D chromatin organization upon vitamin D receptor (VDR) activation at 3.1% of all observed CTCF interactions. VDR binding was enriched at both differential loop anchors and within differential loops. Differential loops were observed in several putative functional roles including TAD border formation, promoter-enhancer looping, and establishment of VDR-responsive insulated neighborhoods. Vitamin D target genes were enriched in differential loops and at their anchors. Secondary vitamin D effects related to dynamic chromatin domain changes were linked to location of downstream transcription factors in differential loops. CRISPR interference and loop anchor deletion experiments confirmed the functional relevance of nuclear receptor ligand-induced adjustments of the chromatin 3D structure for gene expression regulation.
OMARU: a robust and multifaceted pipeline for metagenome-wide association study
Authors: Kishikawa Toshihiro , Tomofuji Yoshihiko , Inohara Hidenori , Okada Yukinori 
Published: March 2022

Abstract
Microbiome is an essential omics layer to elucidate disease pathophysiology. However, we face a challenge of low reproducibility in microbiome studies, partly due to a lack of standard analytical pipelines. Here, we developed OMARU (Omnibus metagenome-wide association study with robustness), a new end-to-end analysis workflow that covers a wide range of microbiome analysis from phylogenetic and functional profiling to case–control metagenome-wide association studies (MWAS). OMARU rigorously controls the statistical significance of the analysis results, including correction of hidden confounding factors and application of multiple testing comparisons. Furthermore, OMARU can evaluate pathway-level links between the metagenome and the germline genome-wide association study (i.e. MWAS-GWAS pathway interaction), as well as links between taxa and genes in the metagenome. OMARU is publicly available (https://github.com/toshi-kishikawa/OMARU), with a flexible workflow that can be customized by users. We applied OMARU to publicly available type 2 diabetes (T2D) and schizophrenia (SCZ) metagenomic data (n = 171 and 344, respectively), identifying disease biomarkers through comprehensive, multilateral, and unbiased case–control comparisons of metagenome (e.g. increased Streptococcus vestibularis in SCZ and disrupted diversity in T2D). OMARU improves accessibility and reproducibility in the microbiome research community. Robust and multifaceted results of OMARU reflect the dynamics of the microbiome authentically relevant to disease pathophysiology.
Management of the patent ductus arteriosus in preterm infants
Authors: Mitra Souvik , Weisz Dany , Jain Amish , Jong Geert ‘t 
Published: March 2022

Abstract
Management of the patent ductus arteriosus (PDA) is one of the most contentious topics in the care of preterm infants. PDA management can be broadly divided into prophylactic and symptomatic therapy. Prophylaxis with intravenous indomethacin in extremely low birth weight infants may reduce severe intraventricular hemorrhage. Echocardiography should be routinely used to confirm the presence of a PDA before considering symptomatic therapy. A symptomatic PDA can be managed conservatively, using pharmacotherapy or with procedural closure. Ibuprofen should be considered as the pharmacotherapy of choice for a symptomatic PDA. High-dose ibuprofen may be preferable, especially for preterm infants beyond the first 3 to 5 days of age. If pharmacotherapy fails (after two courses) or is contraindicated, procedural closure may be considered for infants with a persistent PDA with significant clinical symptoms in addition to echocardiographic signs of a large PDA shunt volume and pulmonary over-circulation.
Partitioning Behaviors of Cobalt and Manganese along Diverse Melting Paths of Peridotitic and MORB-Like Pyroxenitic Mantle
Authors: Chen Chen , Yao Zhuo-Sen , Wang Christina Yan 
Published: March 2022

Abstract
The Co, Mn, Fe, and Ni contents of olivine phenocrysts and host basalts are sensitive to source mantle lithology, which suggests they may be used to constrain the processes of mantle melting and identify basalts formed from non-peridotitic (i.e. pyroxenitic) mantle sources. Here, we use a new comprehensive, forward model involving multiple parameters to simulate partitioning of Co and Mn during partial melting of the mantle in different tectonic settings: (1) polybaric continuous melting of peridotite mantle in mid-ocean ridges can generate melts that show decreasing Co and Mn with increasing degrees of melting so that the mid-ocean ridge basalts (MORBs) contain ~39–84 μg/g Co and ~900–1600 μg/g Mn; (2) flux-melting of the mantle wedge in subduction zones tends to produce a melt that has Co increasing from ~24 to 55 μg/g and Mn from ~500 to 1110 μg/g with increasing temperature; (3) melts produced by isobaric melting of the subcontinental lithospheric mantle are also sensitive to increasing temperature and have ~35–160 μg/g Co and ~800–2600 μg/g Mn; (4) decompression melting of peridotite related to the mantle plume generates melts containing ~45–140 μg/g Co and ~1000–2000 μg/g Mn, and the abundances of these metals decrease with increasing degrees of melting; and (5) partitioning behaviors of Co, Mn, and Ni during decompression melting of MORB-like pyroxenite contrast with those during decompression melting of peridotite due to the different mineralogy and compositions in mantle lithologies, and the MORB-like pyroxenite-derived melt is metal-poor with ~25–60 μg/g Co, ~290–1600 μg/g Mn, and ~160–340 μg/g Ni. Although high-Ni, low-Mn forsteritic olivine phenocrysts and high melt Fe/Mn ratio have been proposed as diagnostic indicators of pyroxenitic components in the mantle, our models show that these features can be also generated by melting of peridotite at greater depth (i.e. a high pressure and temperature). To quantify the effect of high-pressure melting of peridotite on these diagnostic indicators, we modeled the correlations of melt Fe/Mn and olivine Co, Mn, and Ni contents with melting depth along the decompression melting path of a thermal plume. When Fe/Mn ratios of basalts and/or compositions of olivine phenocrysts deviate significantly from our modeled correlation lines, high-pressure melting of peridotite cannot explain these data, and the existence of pyroxenitic component in the mantle source is likely required. The pyroxenite-derived melt is modeled to be Ni-poor, but mixing with a peridotite-derived melt can strongly increase the partition coefficient of Ni between olivine and mixed melt, resulting in the generation of high-Ni olivine phenocrysts in plume-associated magmatic suites.
Emergence of Lie group symmetric classical spacetimes in the canonical tensor model
Authors: Kawano Taigen , Sasakura Naoki 
Published: March 2022

AbstractWe analyze a wave function of a tensor model in the canonical formalism, when the argument of the wave function takes Lie group invariant or nearby values. Numerical computations show that there are two phases, which we call the quantum and the classical phases. In the classical phase fluctuations are suppressed, and configurations emerge which are discretizations of classical geometric spaces invariant under Lie group symmetries. This is explicitly demonstrated for emergence of Sn (n = 1, 2, 3) for SO(n + 1) symmetries by checking the topological and geometric (Laplacian) properties of the emerging configurations. The transition between the two phases has the form of splitting/merging of distributions of variables, resembling a matrix model counterpart, namely the transition between one-cut and two-cut solutions. However, this resemblance is obscured by a difference in the mechanism of distribution in our setup from that in the matrix model. We also discuss this transition as a replica symmetry breaking. We perform various preliminary studies of the properties of the phases and the transition for such values of the argument.
One-particle irreducible Wilson action in the gradient flow exact renormalization group formalism
Authors: Sonoda Hidenori , Suzuki Hiroshi 
Published: March 2022

Abstract
We define a one-particle irreducible (1PI) Wilson action in the gradient flow exact renormalization group (GFERG) formalism as the Legendre transform of a Wilson action. We consider quantum electrodynamics in particular, and show that the GFERG flow equation preserves the invariance of the 1PI Wilson action (excluding the gauge-fixing term) under the conventionalU(1) gauge transformation. This is in contrast to the invariance of the original Wilson action under a modified U(1) gauge transformation. The global chiral transformation also takes the conventional form for the 1PI Wilson action. Despite the complexity of the GFERG flow equation, the conventional form of the gauge and global chiral transformations may allow us to introduce a non-perturbative Ansatz for gauge and chiral invariant 1PI Wilson actions.
Drought Stress Exacerbates Fungal Colonization and Endodermal Invasion and Dampens Defense Responses to Increase Dry Root Rot in Chickpea
Authors: Irulappan Vadivelmurugan , Kandpal Manu , Saini Kumud , Rai Avanish , Ranjan Aashish , Sinharoy Senjuti , Senthil-Kumar Muthappa 
Published: March 2022

Drought plays a central role in increasing the incidence and severity of dry root rot (DRR) disease in chickpea. This is an economically devastating disease, compromising chickpea yields particularly severely in recent years due to erratic rainfall patterns. Macrophomina phaseolina (formerly Rhizoctonia bataticola) is the causal agent of DRR disease in the chickpea plant. The infection pattern in chickpea roots under well-watered conditions and drought stress are poorly understood at present. This study provides detailed disease symptomatology and the characteristics of DRR fungus at morphological and molecular levels. Using microscopy techniques, the infection pattern of DRR fungus in susceptible chickpea roots was investigated under well-watered and drought-stress conditions. Our observations suggested that drought stress intensifies the progression of already ongoing infection by weakening the endodermal barrier and overall defense. Transcriptomic analysis suggested that the plant’s innate immune defense program is downregulated in infected roots when subjected to drought stress. Furthermore, genes involved in hormonal regulation are differentially expressed under drought stress. These findings provide hints in terms of potential chickpea genes to target in crop improvement programs to develop climate-change-resilient cultivars. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
The Development of a Measuring Instrument for Substance Abuse Media Literacy Scale in Students
Authors: Jormand Hanieh , Bashirian Saeed , Barati Majid , Babamiri Mohammad , Rezapur-Shahkolai Forouzan 
Published: March 2022

Objective:
Substance Abuse Media Literacy (SAML) is a scale for assessing substance abuse media literacy among students. This tool can examine the effect of media exposure on substance abuse in youth. Presently, no validated, comprehensive instrument exists to measure media literacy for substance abuse. The current study aimed at assessing the psychometric features of the SAML scale in students.

Methods:
In this cross-sectional validation work, 436 students from Hamadan, Iran, were sampled via the stratified random sampling procedure, and their media literacy regarding substance abuse was investigated. Reliability was assessed by the intraclass correlation coefficient and internal consistency. Moreover, exploratory factor analysis and confirmatory factor analysis were conducted to examine the construct validity. Content Validity Index and Content Validity Ratio were used to examine the content validity.

Results:
Based on the results of factor analysis, the SAML included 13 items that measure 4 components, explaining 63.99% of the usual variance. The means scores for the Content Validity Index and Content Validity Ratio were 0.93 and 0.82, respectively. Further analyses revealed the acceptability of the results for internal consistency reliability values with a Cronbach α of 0.80.

Conclusion:
Based on factor analysis results, the SAML included 13 items is a valid and reliable tool and is now suitable and acceptable for present and future studies.
Practice Variation Within a Single Institution in Management of Degenerative Spondylolisthesis
Authors: Ogink Paul T. , Groot Olivier Q. , van Steijn Nicole , Im Gi Hye , Cha Thomas D. , Hershman Stuart H. , Bono Christopher M. , Schwab Joseph H. 
Published: March 2022

Study Design:
This was a retrospective cohort study.

Objective:
The objective of this study was to assess variation in care for degenerative spondylolisthesis (DS) among surgeons at the same institution, to establish diagnostic and therapeutic variables contributing to this variation, and to determine whether variation in care changed over time.

Summary of Background Data:
Like other degenerative spinal disorders, DS is prone to practice variation due to the wide array of treatment options. Focusing on a single institution can identify more individualized drivers of practice variation by omitting geographic variability of demographics and socioeconomic factors.

Materials and Methods:
We collected number of office visits, imaging procedures, injections, electromyography (EMG), and surgical procedures within 1 year after diagnosis. Multivariable logistic regression was used to determine predictors of surgery. The coefficient of variation (CV) was calculated to compare the variation in practice over time.

Results:
Patients had a mean 2.5 (±0.6) visits, 1.8 (±0.7) imaging procedures, and 0.16 (±0.09) injections in the first year after diagnosis. Thirty-six percent (1937/5091) of patients had physical therapy in the 3 months after diagnosis. CV was highest for EMG (95%) and lowest for office visits (22%). An additional spinal diagnosis [odds ratio (OR)=3.99, P<0.001], visiting a neurosurgery clinic (OR=1.81, P=0.016), and diagnosis post-2007 (OR=1.21, P=0.010) were independently associated with increased surgery rates. The CVs for all variables decreased after 2007, with the largest decrease seen for EMG (132% vs. 56%).

Conclusions:
While there is variation in the management of patients diagnosed with DS between surgeons of a single institution, this variation seems to have gone down in recent years. All practice variables showed diminished variation. The largest variation and subsequent decrease of variation was seen in the use of EMG. Despite the smaller amount of variation, the rate of surgery has gone up since 2007.
Child Abuse
Authors: Overton Julia 
Published: March 2022

ABSTRACT:
Because child abuse occurs across all genders, ethnicities, and socioeconomic groups, nurses working with pediatric patients and their families need keen observation and assessment skills. The purpose of this article is to discuss the recognition, reporting, and appropriate response to child abuse. Caring for children who have been abused and their families is challenging yet presents the opportunity to demonstrate Christ's compassion. Awareness of one's own emotional responses requires meaningful self-care strategies that are also discussed.
Camp Nursing
Authors: Schmidt Karen 
Published: March 2022

ABSTRACT:
Camp nursing offers a unique opportunity for nurses to invest their skills in a novel setting. Nurses fill an essential role in the camp environment and have opportunities to practice a wide variety of tasks with diverse populations of children and teens. The purpose of this article is to inform potential camp nurses of the skill set and aptitudes most inclined to ensure a successful and satisfying camp nursing experience. Serving at a Christian camp also allows nurses to reflect Christ and invest in the faith journey of campers and staff.
Faith Community Nursing
Authors: Reid Roxanne 
Published: March 2022

ABSTRACT:
Spirituality and faith, which are cornerstones of African American churches, also create a receptive setting for health improvement activities. This article presents participant responses to a health improvement intervention to promote church members' self-care. Using the Body & Soul program, the faith community nurse involved laypersons as health ministry team members to support urban African American churchgoers in learning and practicing healthier eating and self-care practices. The health intervention used the Patient Activation Measure (PAM) and incorporated Scripture into weekly sessions, revealing an increase in participants' self-care activation activities.
Telomeres, aging and reproduction
Authors: Córdova-Oriz Isabel , Chico-Sordo Lucía , Varela Elisa 
Published: March 2022

Purpose of reviewWomen's fertility decay starts at the mid 30 s. However, the current delay of childbearing leads to ovarian aging and the need of assisted reproduction technologies (ART). Telomere biology is one of the main pathways involved in organismal aging. Thus, this review will focus on the knowledge acquired during the last 2 years about the telomere pathway and its influence on female fertility and the consequences for the newborn.Recent findingsNew research on telomere biology reaffirms the relationship of telomere attrition and female infertility. Shorter maternal telomeres, which could be aggravated by external factors, underly premature ovarian aging and other complications including preeclampsia, preterm birth and idiopathic pregnancy loss. Finally, the telomere length of the fetus or the newborn is also affected by external factors, such as stress and nutrition.SummaryRecent evidence shows that telomeres are implicated in most processes related to female fertility, embryo development and the newborn's health. Thus, telomere length and telomerase activity may be good biomarkers for early detection of ovarian and pregnancy failures, opening the possibility to use telomere therapies to try to solve the infertility situation.
Incidence and Outcomes of Completion Mastectomy following Oncoplastic Reduction: A Case Series
Authors: Baker Nusaiba F. , Brown Ciara A. , Styblo Toncred M. , Carlson Grant W. , Losken Albert 
Published: March 2022

Background:
Patients occasionally need completion mastectomy (CM) following oncoplastic reduction for various reasons necessitating definitive reconstructive techniques. The purpose of this study was to evaluate those patients who required CM following oncoplastic reduction and evaluate indications, technique, and outcomes.

Methods:
Patients who underwent a completion mastectomy at some time point following the oncoplastic reduction were identified. Factors that influenced CM and additional reconstruction were analyzed. All statistical analysis was conducted using the IBM SPSS Statistics 27.0 (IBM Corp.).

Results:
A total of 29 patients (5.3%) underwent CM during the study period with an average follow-up of 3 years since the original procedure. The most common reasons were positive margins (20/29, 69.0%) and recurrence (8/29, 27.6%). Twenty-two had reconstructive procedures (75.9%) and seven did not (24.1%). The patients who underwent CM and reconstruction were significantly younger (49.2 years) than those who had no reconstruction (64.3 years, P = 0.004). The most common type of reconstruction was transverse rectus abdominis myocutaneous (TRAM)/deep inferior epigastric perforator (DIEP) flap (12/22, 54.5%), followed by latissimus (6/22, 27.3%) and tissue expander (3/22, 13.6%). The complication rate in the CM group was 24% (N = 7/29), which included two seromas (6.9%), followed by infection, fat necrosis, mastectomy skin necrosis, and donor site necrosis (3.4% each).

Conclusions:
Completion mastectomy is indicated typically for positive margins or recurrence. Reconstruction is performed more frequently in younger patients, with the TRAM/DIEP flap and latissimus dorsi reconstruction being the most common technique.
Transumbilical Single-incision Laparoscopic Surgery for Harvesting Rib and Costal Cartilage
Authors: Zhang Lu , Huo Haizhong , Li Hongjie , Luo Meng , Wang Feng , Zhou Yixiong , Li Qingfeng , Zhang Yuguang 
Published: March 2022

Background:
The study aimed to introduce a rib and costal cartilage harvesting surgery by transumbilical single-incision laparoscopy and evaluate its efficiency and safety.

Methods:
Patients who underwent rib and costal cartilage harvest under different approaches (direct open approach and transumbilical) were collected in this retrospective study. The differences in the pain scores [visual analog scale (VAS)], postoperative appearance, and complications were compared between the two groups at 1, 2, 3, and 7 days after surgery. In addition, based on the minimal clinically important difference and the generalized estimating equation, the differences were compared between the two groups in terms of the VAS score.

Results:
On postoperative day 1, the VAS scores of the direct open approach group and the transumbilical group were significantly different, that is, 7.29 and 6.10, respectively (P < 0.001). Also, the generalized estimating equation results were different (P < 0.001). An interaction was observed between different groups and days, that is, a statistical difference was observed in the VAS score between the two groups (P < 0.001). In terms of aesthetics and complications, patients from the transumbilical group had no scars on the chest wall and no obvious postoperative complications.

Conclusions:
Transumbilical single-incision laparoscopic surgery is an innovative surgical approach for harvesting ribs and costal cartilage, which leaves no scars on the skin of the chest wall and has the advantages of slight postoperative pain, quick recovery, and fewer complications. This novel surgery is beneficial to patients with higher aesthetic requirements.