bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biostimulant effects of lanthanum (La) on crop growth, yield, and quality
Authors: Contreras-Martínez Guadalupe , Gómez-Merino Fernando C. , Peralta-Sánchez María G. , Alcántar-González Gabriel , Trejo-Téllez Libia I 
Published: August 2022

Objective: To analyze the various effects that the use of La as an inorganic biostimulant has on growth, yield and quality of different crop plants.
Design/methodology/approach: A search in recent literature related to the effects of lanthanum on various economically important crops was conducted. Subsequently, the most relevant information was selected, analyzed and grouped by type of effect.
Results: The addition of lanthanum at low doses has been tested in different crop plants. It has been proven that La increases growth, development and quality in various species. Likewise, positive effects have been reported in germination, in the absorption of nutrients, in mitigating the deficiencies of some essential elements, as well as in the promotion of physiological and biochemical responses.
Limitations/implications of the study: The analyzed results have been generated in a great diversity of plant species, under different production systems, with dissimilar doses, as well as with different sources and application methods. This situation represents a challenge, since it hinders the possibility to issue general recommendations.
Findings/conclusions: Lanthanum improves yield and quality, as well as some physiological, biochemical and nutritional responses in different crops of economic importance.
Sensory perspectives of the consumption of chips-type snacks made from black bean (Phaseolus vulgaris L) and peanut (Arachis hypogaea Linn) flours by university students in the Toluca Valley
Authors: Robledo-Ramírez L.H. , Bautista-Mora G.N. , Domingo-Gonzales A.K. , Flores-Rodríguez M.L. , Ramírez-Peñaloza S. , Cruz-Monterrosa R.G. , González-Martínez A.J. , Martínez-Arellano I. I. , Álvarez-Cisneros Y.M. 
Published: August 2022

Objective: The objective of this study is to evaluate the sensory perspectives of chips-type snacks made from black bean dry (Phaseolus vulgaris L) and peanut (Arachis hypogaea Linn) flours in a university population.
Design/methodology/approach: Two formulations were realized from peanut and black bean previously toasted and milled: 1) (PF) 50% peanut flour, 12.5% rice flour and 12.5 % cornstarch; 2) (BbF) 50% black bean flour, 12.5% wheat flour and 12.5% cornstarch. Each mixture of flours was extruded and fried until obtained chips-type snacks. A statistical-descriptive study was carried out from the observation of the eating habits of university students in the State of Mexico. On other hand, an affective test was tested to evaluate the acceptance of chips-type snacks made with PF and BbF in the categories of odor, taste, hardness, and easy to break.
Findings/conclusion:
According to the questionnaire, the female gender has higher snack consumption than the male population. On another hand, potato chips are in third place as the most consumed snacks for women they preferred to consume them in their houses. Peanut and chickpea flour are the most preferred by the female population. There was no significant difference (p˃0.05) between the snacks prepared with PF and BbF, but 60% of the consumer accepted both snacks. It is concluded that the chips-type snacks made with different formulations could be a healthy alternative for the students, also it kind of products have good acceptability. Finally knowing the sensory perspectives could provide important information for developing healthier and easier-to-eat snacks.
Limitations on study/implications: More studies about the characterization of the chips-type snacks are required, also a mix of both legumes could be realized.
PENGEMBANGAN SOAL IPA MATERI SIKLUS AIR BERBASIS LITERASI SAINS MENGGUNAKAN APLIKASI QUIZIZ UNTUK KELAS V SEKOLAH DASAR
Authors: Wibowo Andi , Yunia Rista 
Published: August 2022

Tujuan penelitian ini adalah: (1) dapat mengembangkan soal berbasis literasi sains melalui aplikasi quiziz untuk kelas V SD (2) mengetahui valid dan reliabel dalam soal pilihan ganda (3) mengetahui kelayakan pada instrumen soal literasi sains (4) mengetahui respon siswa terhadap kemenarikan pada pengembangan soal berbasis literasi sains dengan menggunakan aplikasi quiziz. Model pengembangan yang digunakan adalah model ADDIE. Subjek penelitian merupakan siswa kelas V SDN Bringin 2 Wajak dengan jumlah 20 siswa pada uji coba lapangan. Prosedur penelitian diantaranya tahap analisis, perancangan, pengembangan, implementasi dan evaluasi. Teknik yang digunakan dalam pengumpulan data adalah wawancara, observasi, angket, dokumentasi. Instrument yang diadalah lembar pedoman wawancara, lembar angket validasi. Hasil yang didapat pada ahli instrumen dan ahli media yaitu ahli media mendapatkan presentase 98% dengan kategori “Sangat Layak”, ahli instrument mendapatkan presentase 98% dengan kategori “Sangat Layak”, respon guru mendapatkan presentase 96,3% dengan kategori “Sangat Layak”, respon Siswa kelompok kecil mendapatkan presentase 4,00% dengan kategori “Sangat Layak”. Hasil uji coba lapangan presentase yang didapat 3,93 “sangat menarik”.
PENGEMBANGAN MEDIA BUSA SEDAP (BUKU SAKU SUMBER ENERGI DAN PERUBAHAN) TEMATIK UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA KELAS III SEKOLAH DASAR
Authors: Yanti Yulia Eka , Himmah Nur Faizah Nafiatul 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui motivasi belajar siswa kelas III sekolah dasar dengan mengaplikasikan media yang diberi nama Busa Sedap yang valid dan dapat digunakan juga dapat membantu siswa.Penelitian ini menggunakan metode penelitian RnD (Research and Development). Prosedur penelitian pengembangan yang dillakukan mengadaptasi model pengembangan Borg&Gall yang terdiri dari 9 tahap: 1) potensi dan masalah, 2) pengumpulan data, 3) desain produk, 4) validasi produk, 5) revisi produk, 6) uji coba produk terbatas, 7) revisi produk II, 8) uji coba produk utama, 9) revisi produk III. Subjek pada penelitian ini adalah 15 siswa kelas III SD NU Hasanuddin Dilem 02. Teknik pengumpulan data, peneliti menggunakan instrumen penelitian meliputi: wawancara, angket motivasi, angket keterbacaan,serta dokumentasi. Hasil analisis data penilaian media Busa Sedap oleh validator menunujukkan persentase 98,6%. Sedangkan hasil validasi ahli materi menghasilkan persentase 92,5%. Dari keseluruhan hasil validasi tersebut menunjukkan bahwa media busa sedap layak dan valid untuk digunakan dalam proses pembelajaran. Hasil angket motivasi belajar yang diperoleh dari angket before diperoleh hasil 33,2%, sedangkan angket motivasi belajar after diperoleh hasil 75% maka diperoleh peningkatan sebanyak 41,8%. Berdasarkan hasil dari penelitian tersebut, maka dapat disimpulkan bahwa penggunaan media busa sedap dapat memotivasi belajar siswa.
PENGGUNAAN MEDIA KARTU GAMBAR UNTUK MENINGKATKAN KETERAMPILAN MEMBACA SISWA DALAM PEMBELAJARAN TEMATIK DI KELAS 2 SDN 01 LANDUNGSARI
Authors: Safitri Amita , Mukhlishina Innany 
Published: August 2022

Penelitian ini dilatarbelakangi karena kurangnya minat membaca siswa serta kurangya kemampuan siswa dalam keterampilan membaca, semua itu karna keterampilan membaca merupakan kemampuan membaca dengan baik dan benar dan juga kemampuan yang harus di miliki oleh setiap orang. Tidak hanya keterampilan membaca saja yang penting akan tetapi keterampilan menulis, berbicara, dan mendengarkan juga penting bagi kehidupan sehari- hari. Keterampilan membaca ini juga sangat penting dalam pembelajaran tematik. Dalam pembelajaran tematik terdapat tema dan subtema dan di dalamnya harus memuat kompetensi dasar (KD) dan kompetensi inti (KI). Penggunaan media pembelajaran sangatlah penting untuk mendukung suatu kegiatan pembelajaran agar mencapai suatu tujuan yang telah di rencanakan. Penelitian ini bertujuan untuk mengetahui bagaimana perkembangan pembelajaran dalam keterampilan membaca siswa di kelas 2 SDN 01 Landungsari, dan untuk mengetahui bagaimana penerapan atau pengguanaan media kartu gambar dalam meningkatkan keterampilan membaca pada siswa kelas 2 SDN 01 Landungsari. Dan subjek dalam penelitian ini yaitu siswa kelas 2 SDN 01 Landungsari, dan metode yang di gunakan dalam penelitian ini yaitu penelitian Tindakan kelas (PTK) dan pengamatan dengan melakukan observasi awal dan pedoman wawancara. Berdasarkan hasil dari penelitian termasuk hasil dari kedua siklus bahwa dengan menggunakan media kartu gambar tidak sepenuhnya meningkatkan keterampilan membaca siswa kelas 2 SDN 01 Landungsari, semua itu harus di imbangi dengan usaha keras dari seorang guru saat memberikan pengajaran dan sebuah dorongan atau dukungan dari orang-orang terdekatnya.
A Inteligência Artificial a favor da aprendizagem dos alunos com deficiência
Authors: Gonçalo Camilla Viana de Souza , Carvalho Aline dos Santos Moreira de , Araújo Antônio Marcondes de 
Published: August 2022

A Inteligência Artificial inserido no setor educacional proporciona ao deficiente um aprendizado diferenciado, o ajudando a aumentar o engajamento do aluno. Isso porque são diferentes recursos de tecnologia disponibilizados a qualquer momento, como a gamificação, que elevam o interesse do estudante pela educação, dessa essa estratégia transforma os alunos em protagonistas com habilidades fundamentais e mais conhecimento. Com cada vez mais invenções disponíveis online que não sejam trazidas apenas pelo educador, a Inteligência Educacional é uma boa ideia para os alunos aprenderem do lugar onde estiverem. Além de estimular o aprendizado, é possível criar sistemas personalizados com o perfil de cada aluno. A referida pesquisa baseia-se em dados bibliográficos, elaborada a partir de material já publicado, como livros, artigos, periódicos, internet, e em dados qualitativos vez que que visa abordar os aspectos subjetivos de fenômenos sociais e do comportamento humano procurando, deste modo, abordar temas que não podem ser quantificados em equações e estatísticas, de base metodológica de paradigma sistêmico, pautada na teoria da complexidade tendo como objeto de estudo as inteligências artificiais inseridas nos ambientes educacionais como promoção de aprendizagem.
Korelasi Antara Indeks Masa Tubuh (Imt) Dengan Kemampuan Mengecap Phenylthiocarbamide (Ptc) Pada Mahasiswa Fakultas Kedokteran Universitas Yarsi Angkatan 2019
Authors: Purwaningsih Endang , Mirfat Mirfat , Widayanti Etty 
Published: August 2022

Gangguan pengecapan terhadap phenylthiocarbamide (PTC) merupakan suatu sifat yang diwariskan dan berpengaruh terhadap preferensi makanan serta diet. Hal ini akan berpengaruh terhadap berat badan/adipositas yang berperan sebagai kontributor terhadap berbagai komorbid seperti obesitas. Obesitas merupakan salah satu penyebab utama berbagai komplikasi kesehatan di negara-negara berkembang terutama pada orang dewasa. Tujuan penelitian adalah mengetahui korelasi antara Indeks Masa Tubuh dengan kemampuan mengecap phenylthiocarbamide (PTC) pada mahasiswa Fakultas Kedokteran Universitas YARSI Angkatan 2019.Metode penelitian adalah kuantitatif dengan jenis penelitian eksperimental dan rancangan cross sectional. Subyek diintruksikan untuk menjulurkan lidahnya, dan diteteteskan larutan phenylthiocarbamide di bagian tengah lidah. Kemudian ditanya, apa yg dia rasakan, pahit atau tidak pahit. Pengumpulan data tentang berat badan dan tinggi badan dilakukan dengan cara kuisioner.Hasil penelitian menunjukkan sebagian besar mahasiswa Fakultas Kedokteran Universitas YARSI Angkatan 2019 memiliki rata-rata Berat Badan, Tinggi Badan dan Indeks Masa Tubuh (IMT) masing-masing adalah sebesar 61,1888 kg kurang lebih 15,4728, 162,74 cm kurang lebih 0,1018 dan 23,0426 kurang lebih 5,0450. Menurut klasifikasi WHO sebagian besar sampel memiliki berat badan ideal. Dari pengujian PTC didapatkan insidensi kelompok taster sebesar 71, 5 % dan kelompok nontaster sebesar 28,5 %. Tidak ada korelasi yang signifikan antara IMT dengan kemampuan sebagai taster atau non taster (p lebih besar dari 0,05).Disimpulkan bahwa kemampuan mengecap PTC tidak mempengaruhi Indeks Masa Tubuh (IMT) pada mahasiswa FK Universitas YARSI Angkatan 2019. Sebagian besar mahasiswa memiliki Indeks Masa Tubuh ideal
CuS nanoparticles and camptothecin co-loaded thermosensitive injectable hydrogel with self-supplied H2O2 for enhanced chemodynamic therapy
Authors: Tang Wenxue , Li Xiang , Liu Zeming , Meng Lyu , Zhu Daoming , Huang Qinqin 
Published: August 2022

Chemodynamic therapy (CDT) is a kind of anti-tumor strategy emerging in recent years, but the concentration of hydrogen peroxide (H2O2) in the tumor microenvironment is insufficient, and it is difficult for a single CDT to completely inhibit tumor growth. Here, we designed a CuS nanoparticles (NPs) and camptothecin (CPT) co-loaded thermosensitive injectable hydrogel (SCH) with self-supplied H2O2 for enhanced CDT. SCH is composed of CuS NPs and CPT loaded into agarose hydrogel according to a certain ratio. We injected SCH into the tumor tissue of mice, and under the irradiation of near-infrared region (NIR) laser at 808 nm, CuS NPs converted the NIR laser into heat to realize photothermal therapy (PTT), and at the same time, the agarose hydrogel was changed into a sol state and CPT was released. CPT activates nicotinamide adenine dinucleotide phosphate oxidase, increases the level of H2O2 inside the tumor, and realizes the self-supply of H2O2. At the same time, CuS can accelerate the release of Cu2+ in an acidic environment and light, combined with H2O2 generated by CPT for CDT treatment, and consume glutathione in tumor and generate hydroxyl radical, thus inducing tumor cell apoptosis. The SCH system we constructed achieved an extremely high tumor inhibition rate in vitro and in vivo, presenting a new idea for designing future chemical kinetic systems.
A higher spectral range of beetle bioluminescence with infraluciferin
Authors: Jathoul Amit P. , Branchini Bruce R. , Anderson James C. , Murray James A. H. 
Published: August 2022

Coleopteran bioluminescence is unique in that beetle luciferases emit colors ranging between green (ca.550 nm) and red (ca.600 nm), including intermediate colors such as yellow and orange, allowing up to 3 simultaneous parameters to be resolved in vitro with natural luciferin (D-LH2). Here, we report a more than doubling of the maximum bioluminescence wavelength range using a single synthetic substrate, infraluciferin (iLH2). We report that different luciferases can emit colors ranging from visible green to near-infrared (nIR) with iLH2, including in human cells. iLH2 was designed for dual color far-red to nIR bioluminescence imaging (BLI) in small animals and has been utilized in different mouse models of cancer (including a metastatic hepatic model showing detailed hepatic morphology) and for robust dual parameter imaging in vivo (including in systemic hematological models). Here, we report the properties of different enzymes with iLH2: Lampyrid wild-type (WT) Photinus pyralis (Ppy) firefly luciferase, Ppy-based derivatives previously engineered to be thermostable with D-LH2, and also color-shifted Elaterid-based enzymes: blue-shifted Pyrearinus termitilluminans derivative Eluc (reported D-LH2 λmax = 538 nm) and red-shifted Pyrophorus plagiopthalamus derivative click beetle red (CBR) luciferase (D-LH2 λmax = 618 nm). As purified enzyme, in bacteria or in human cells, Eluc emitted green light (λmax = 536 nm) with DL-iLH2 whereas Ppy Fluc (λmax = 689 nm), x2 Fluc (λmax = 704 nm), x5 Fluc (λmax = 694 nm), x11 Fluc (λmax = 694 nm) and CBR (λmax = 721 nm) produced far-red to nIR peak wavelengths. Therefore, with iLH2, enzyme λmaxes can be separated by ca.185nm, giving almost non-overlapping spectra. This is the first report of single-substrate bioluminescence color emission ranging from visible green to nIR in cells and may help shed light on the color tuning mechanism of beetle luciferases. We also report on the reason for the improvement in activity of x11 Fluc with iLH2 and engineer an improved infraluciferase (iluc) based on this mutant.
The extended effect of adsorbed damage-associated molecular patterns and Toll-like receptor 2 signaling on macrophage-material interactions
Authors: Kaushal Anuj , Zhang Yuxi , Ballantyne Laurel L. , Fitzpatrick Lindsay E. 
Published: August 2022

Implanted biomaterials elicit an immune-mediated foreign body reaction (FBR) that results in the fibrous encapsulation of the implant and can critically impact the performance of some implants. Consequently, understanding the molecular mechanisms that underpin cell-materials interactions that initiate biomaterial-induced inflammation and fibrosis is critical to improving the performance of biomaterial implants negatively impacted by the FBR. Damage-associated molecular patterns (DAMPs) are endogenous mediators of inflammation that are released upon tissue injury and induce sterile inflammationviaToll-like receptors (TLRs). However, the prevalence of DAMPs within the adsorbed protein layer on material surfaces and their role mediating cell-material interactions is unclear. Previously, our group demonstrated that molecules in fibroblast lysates adsorbed to various biomaterials and induced a potent TLR2-dependent inflammatory response in macrophages at 24 h. In this study, we examined the extended response of RAW-Blue reporter macrophages on lysate or serum-adsorbed Teflon™ AF surfaces to understand the potential role of adsorbed DAMPs in macrophage-material interactions at later time points. Lysate-conditioned surfaces maintained increased nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1) transcription factor activity and increased expression Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES/CCL5) at 72 h and 120 h, compared to FBS-conditioned surfaces. In contrast, monocyte chemoattractant protein 1 (MCP-1/CCL2) was only elevated at 72 h in lysate conditions. Transforming growth factor beta 1 (TGF-β1) secretion was significantly increased on lysate-conditioned surfaces, while conditioned media from macrophages on lysate-conditioned surfaces induced alpha smooth muscle actin (αSMA) expression in 3T3 fibroblasts. TLR2 neutralizing antibody treatment significantly decreased NF-κB/AP-1 activity and attenuated TGF-β1 expression at both time points, and MCP-1 and RANTES at 72 h. Finally, multinucleated cells were observed on lysate-conditioned surfaces at 72 h, indicating adsorbed DAMPs induced a fusion permissive environment for adherent macrophages. This study demonstrates that adsorbed DAMPs continue to influence macrophage-material responses beyond the initial 24-h period and maintain a pro-inflammatory and fibrotic response that models aspects of the early FBR. Furthermore, the transient inhibition of TLR2 continued to exert an effect at these later time points, suggesting TLR2 may be a target for therapeutic interventions in FBR.
Transcriptomic analysis provides a new insight: Oleuropein reverses high glucose-induced osteogenic inhibition in bone marrow mesenchymal stem cells via Wnt10b activation
Authors: Lao An , Chen Yu , Sun Yiting , Wang Tiange , Lin Kaili , Liu Jiaqiang , Wu Jianyong 
Published: August 2022

Adverse events of diabetes mellitus (DM) include bone damages, such as the increased incidence of osteoporosis and bone fractures, which are known as diabetic osteopathy. The pathogenic mechanism of diabetic osteopathy is complex, and hyperglycemia is a vital cause involved in it. Bone marrow mesenchymal stem cells (BMSCs) exert a significant effect on bone formation. Therefore, in this paper, transcriptomic changes of BMSCs cultured in high glucose (35 mM) for 30 days are mainly investigated. In addition, 794 up-regulated genes and 1,162 down-regulated genes were identified. Then, biological functions of the differentially expressed genes in the high glucose microenvironment were investigated by two kinds of functional analyses. Gene Set Enrichment Analysis was also applied to focus on the significant gene sets and it is found that Wnt10b expression witnessed a remarkable decrease in BMSCs under the high glucose microenvironment. At last, in vitro experiments revealed that oleuropein effectively reversed high glucose-induced osteogenic inhibition via activating Wnt10b in BMSCs.
Construction of a novel exosomes-related gene signature in hepatocellular carcinoma
Authors: Tao Qiqi , Zhu Kai , Zhan Yating , Zhang Rongrong , Lang Zhichao , Yu Zhengping , Wang Meng 
Published: August 2022

Background: Exosomes are extracellular vesicles between 40 and 150 nm in diameter and are cargoes for a wide range of small biological molecules. Recent studies have reported that lncRNAs, miRNAs, circRNAs in serum exosomes may serve as biomarkers to predict hepatocellular carcinoma (HCC) prognosis. However, the prognostic values of exosomes-related mRNAs in HCC are still unclear.Methods: Data of HCC patients were downloaded from The Cancer Genome Atlas (TCGA) database. The serum exosome sequencing data of HCC patients and healthy individuals were obtained from the exobase database. Univariate cox regression analysis was used to identify prognostic exosomes-related genes. LASSO and multivariate cox regression analyses were applied to construct prognostic signature.Results: 22 exosomes-related mRNAs differentially expressed between HCC tissues and normal tissues were identified. Then, 8 prognostic exosomes-related mRNAs were screened. Subsequently, G6PD and ADAMTS5, selected by LASSO and multivariate cox regression analyses, were used to construct a prognostic signature. The patients with high-risk scores had a poor prognosis in TCGA cohort as well as ICGC cohort. Notably, this prognostic signature was also validated in a local cohort collected from the First Affiliated Hospital of Wenzhou Medical University. Receiver Operating Characteristic (ROC) analyses indicated that the signature had a good performance in all the cohorts. The gene set enrichment analysis revealed that this signature was associated with cell cycle and metabolism pathways. Immune infiltration analysis indicated that the patients with high-risk scores had a higher M0 macrophages infiltration. The univariate and multivariate cox regression analyses identified that the risk score is an independent risk factor for HCC. In addition, a nomogram containing age, gender, stage and risk score was constructed to precisely predict HCC prognosis.Conclusion: In conclusion, we develop a novel exosomes-related gene signature that helps to predict HCC prognosis.
Carboxylated graphene oxide nanosheets as efficient electrodes for high-performance supercapacitors
Authors: Abdu Hassan Idris , Hamouda Hamouda Adam , Orege Joshua Iseoluwa , Ibrahim Mohammed Hassan , Ramadan Anas , Aboudou Taslim , Zhang Hongxia , Pei Jinjin 
Published: August 2022

In the presence of dry ice, a series of graphitic materials with carboxylated edges (ECGs) were synthesized by ball milling graphite for varied times (24, 36, and 46 h). The influence of carboxylation on the physiochemical characteristics and electrochemical performance as effective electrodes for supercapacitors were assessed and compared with pure graphite. Several characterization techniques were employed to investigate into the morphology, texture, microstructure, and modification of the materials. Due to its interconnected micro-mesoporous carbon network, which is vital for fast charge-discharge at high current densities, storing static charges, facilitating electrolyte transport and diffusion, and having excellent rate performance, the ECG-46 electrode among the investigated samples achieved the highest specific capacitance of 223 F g−1 at 0.25 A g−1 current density and an outstanding cycle stability, with capacitance retention of 90.8% for up to 10,000 cycles. Furthermore, the symmetric supercapacitor device based on the ECG-46 showed a high energy density of 19.20 W h kg−1 at 450.00 W kg−1 power density. With these unique features, ball milling of graphitic material in dry ice represents a promising approach to realize porous graphitic material with oxygen functionalities as active electrodes.