bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral blood kinetics following total body irradiation and allogeneic hematopoietic stem cell transplantation: Timing matters
Authors: Dejonckheere Cas S. , Böhner Alexander M. C. , Schmitz Eva , Holderried Tobias A. W. , Schmeel Leonard C. , Brossart Peter , Giordano Frank A. , Köksal Mümtaz A. 
Published: November 2022

AbstractTotal body irradiation (TBI) remains an important component in many conditioning regimens before allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Because of its frequent toxicity, patient selection is crucial, making it of interest to identify factors improving engraftment. In this retrospective single center analysis, the characteristics of 48 adult such patients were studied. Mean overall survival (OS) was 22.2 months after allo‐HSCT. Interestingly, people with an interval ≥3 days between TBI completion and allo‐HSCT showed improved OS, when compared to a shorter interval (p = 0.10). Peripheral blood kinetics after successful engraftment also differed, with a longer interval resulting in a higher platelet count and lower leukocyte and neutrophil (p < 0.05) count. These data suggest that the exact timing of TBI before allo‐HSCT might directly impact a patient's survival and could help single out those at higher risk of graft failure who might benefit from an altered conditioning regimen.
Observation of Alectinib‐ and Crizotinib‐ included chemotherapy in children with ALK‐positive anaplastic large cell lymphoma: A single institutional experience
Authors: He Yingyi , Pei Kunlin , Zhang Hui , Wang Jiayi , Su Xiaoling , Gan Wenting , Wang Pengfei 
Published: November 2022

AbstractApproximately one‐third children with anaplastic large cell lymphoma (ALCL) relapse after completion of chemotherapy, particularly for those high‐risk patients. The introduction of novel therapeutic modalities is much needed for these sub‐group patients. Two groups (n = 3, n = 4) of ALCL patients were treated with crizotinib‐ and alectinib‐included ALCL‐99 therapy, respectively, achieving complete remission rates of 66.7% and 100%. Two patients of crizotinib group relapsed, while none relapsed among the alectinib‐treated patients. Adding alectinib instead of crizotinib sufficiently suppressed and maintained the deep NPM‐ALK molecular response. ALK inhibitors were well tolerated with only grade 1 adverse events in both groups. Though a relatively small case number, this study raised the possibility that alectinib‐included therapeutic regimens may benefit the early response, in‐depth molecular remission, and persistent remission to some extent. Further studies are warranted to validate our preliminary findings.
Marathi SentiWordNet: A lexical resource for sentiment analysis of Marathi
Authors: B. Shelke Mahesh , Sawant Daivat D. , Kadam Chatrabhuj B. , Ambhure Kailas , Deshmukh Sachin N. 
Published: November 2022

SummarySentiment analysis (SA) is information retrieval and computational linguistics that expresses sentiment about a specific document. Recently, research on SA has received greater interests due to the vast expansion of internet data. The comments and reviews posted online creates difficulties to the researchers, because the comments posted are written in unstructured formats with informal expressions, languages and possibly mixed languages. Most of the works on SA have been focusing only on English language but with respect to Indian languages, few works are done, especially on Hindi, Telugu, Bengali, and so forth. SentiWordNet is a useful lexical resource for determining the sentiment of a document or piece of text. There is currently no lexical resource for the Marathi language used for sentiment analysis. Therefore, this proposed research presents SA in one of the languages of Indian origin, that is, Marathi. In this paper, a new method is proposed for the development of a Marathi SentiWordNet (M‐SWN), synset‐based expansion approach using Marathi WordNet, which consists of Positive, Negative, and Neutral Polarity score, mapped from Hindi‐SentiWordNet (H‐SWN). Finally, sentiment analysis of movie reviews is carried out using M‐SWN using Bi‐LSTM based SVM classifier model.
The Bethesda system for reporting thyroid fine needle aspirates: A study of 1763 patients; with histopathological correlations, in eastern India
Authors: Sen Ankita , Sarkar Manisha , Das Ram Narayan , Paul Shib Shankar , Chatterjee Uttara 
Published: November 2022

AbstractBackgroundFine‐needle aspiration cytology (FNAC) is an important test for triaging patients with thyroid nodules. The 2007 National Cancer Institute Thyroid Fine‐Needle Aspiration State‐of‐the‐Science Conference helped instigate the recent publication of The Bethesda System for Reporting Thyroid Cytopathology (TBS).Aims and ObjectivesTerminology and therefore the probability of malignancy vary between pathologists and institutions. The purpose of this study was to evaluate a single institution's experience to determine if sub‐classification (neoplasm versus lesion) aids in identifying patients at higher risk for malignancy. Also, an effort in regional and worldwide variation of significance of adoption of Bethesda classification has been evaluated.Materials and MethodsFrom 2018 to 2021, all patients with thyroid lesions' were evaluated for FNAC correlation with the surgical diagnosis. During this period, 1763 thyroid FNACs were reported. Histopathological examination (HPE) outcome data was available in 444 (25.2%) cases.ResultsThe cytologic‐histologic diagnostic discrepancy rate was 11.5%. The sensitivity and specificity of thyroid FNA for the diagnosis of malignancy were 71.4% and 49.5%, respectively. In our study, the maximum cases were benign (84.5%). The malignancy risk for the different categories in our study, as seen by follow‐up HPE, has corroborated well with the Bethesda System.ConclusionThe current results indicated that FNAC provides an accurate diagnosis of thyroid malignancy. The classification is directly related to the risk of malignancy in each category and this helps in accurate clinical management of that category.
Multicoloured flow cytometry to detect metastatic carcinoma in lymph node by epithelial cell adhesion molecule
Authors: Pradhan Nupur , Susheilia Shaily , Gupta Parikshaa , Kundu Reetu , Rajasekaran Sangamitra , Dey Pranab 
Published: November 2022

AbstractBackgroundThe metastatic carcinoma in the lymph node may be missed in routine fine needle aspiration cytology (FNAC). There are limited studies on the role of epithelial cell adhesion molecule (EpCAM) in detecting metastatic carcinoma in the FNAC of lymph nodes by flow cytometry (FCM).AimsTo evaluate the role of EpCAM in flow cytometry detecting metastatic carcinoma in the fine needle aspiration cytology (FNAC) of the lymph node.Materials and MethodsIn this prospective study, successive 42 cases of lymph nodes were subjected to FNAC followed by flow cytometry to detect the EpCAM positive cell population. The sample was used for cytology and FCM (CD45, CD14, and EpCAM antibodies tagged with fluorochromes). The percentage of EpCAM positive cell population in each case was calculated and compared in the metastatic carcinomas and reactive lymphoid hyperplasia (RLH) cases.ResultThere were 29 cases of metastatic carcinoma and 13 non‐neoplastic cases (12 RLH and one granulomatous inflammation). The average percentages of EpCAM in metastatic carcinoma and reactive lymphoid cells were 11.37 and 1.24, respectively. The independent sample t‐test showed a significant difference (0.001) in the percentage of EpCAM in the two groups. The cut of value of 3% EpCAM in FCM showed 97% sensitivity and 92% specificity to detect metastatic carcinoma in FNAC of the lymph node.ConclusionThe percentage of EpCAM in FCM may be helpful in detecting metastatic carcinoma in the lymph node. The FCM is a rapid and quantitative test with high sensitivity and specificity.
Overview of the KMA/NIMS Atmospheric Research Aircraft (NARA) and its data archive: Annual airborne observations over the Korean peninsula
Authors: Kim Ji‐Hyoung , Goo Tae‐Young , Jung Sueng‐Pil , Kim Min‐Seong , Lee Kwangjae , Kang Myeonghun , Lee Chulkyu , Yang Jiwhi , Hong Sungeun , Ko Heejong , Yun Jong Hwan 
Published: November 2022

AbstractThis study describes the Korea Meteorological Administration/National Institute of Meteorological Sciences (KMA/NIMS) Atmospheric Research Aircraft (NARA) and its observational data archive. NARA has been performing annual observation flights, which are aimed at reducing the uncertainty of atmospheric observations in the observation data gap area around the Korean peninsula, since January 2018. An online system has also been constructed to provide data management, transmission, quality control and simple visualization. The mission strategy of NARA is subdivided into four individual units, namely observations of severe weather (SW), climate monitoring (CM), environmental monitoring (EM) and cloud physics and weather modification experiments (CP). As of December 2020, NARA has been launched operationally for 325 flights (corresponding to 9.02 flights per month), typically over the West Sea, mid‐inland areas (34.4% and 25.4%, respectively), and below an altitude of 3 km (51.9%). Results of intercomparison tests confirmed that NARA measurements have reasonable offsets (<0.9%) to each other in terms of pressure and temperature. Moreover, the monthly average temperature profile in the East Sea area showed a seasonal variation was detected in monthly variation. From these results, it is evident that NARA data will contribute significantly to enhancing the level of scientific understanding of atmospheric observations and the applications (i.e. long‐term study) thereof as the amount of data accumulated increases.
Contribution of inwardly rectifying K+ channel 4.1 of supraoptic astrocytes to the regulation of vasopressin neuronal activity by hypotonicity
Authors: Jiang Yun‐Hao , Li Tong , Liu Yang , Liu Xiaoyu , Jia Shuwei , Hou Chunmei , Chen Guichuan , Wang Hongyang , Ling Shuo , Gao Qiang , Wang Xiao‐Ran , Wang Yu‐Feng 
Published: November 2022

AbstractAstrocytic morphological plasticity and its modulation of adjacent neuronal activity are largely determined by astrocytic volume regulation, in which glial fibrillary acidic protein (GFAP), aquaporin 4 (AQP4), and potassium channels including inwardly rectifying K+ channel 4.1 (Kir4.1) are essential. However, associations of astrocyte‐dominant Kir4.1 with other molecules in astrocytic volume regulation and the subsequent influence on neuronal activity remain unclear. Here, we report our study on these issues using primary cultures of rat pups' hypothalamic astrocytes and male adult rat brain slices. In astrocyte culture, hyposmotic challenge (HOC) significantly decreased GFAP monomer expression and astrocytic volume at 1.5 min and increased Kir4.1 expression and inwardly rectifying currents (IRCs) at 10 min. BaCl2 (100 μmol/l) suppressed the HOC‐increased IRCs, which was simulated by VU0134992 (2 μmol/l), a Kir4.1 blocker. Preincubation of the astrocyte culture with TGN‐020 (10 μmol/l, a specific AQP4 blocker) made the HOC‐increased Kir4.1 currents insignificant. In hypothalamic brain slices, HOC initially decreased and then increased the firing rate of vasopressin (VP) neurons in the supraoptic nucleus. In the presence of BaCl2 or VU0134992, HOC‐elicited rebound increase in VP neuronal activity was blocked. GFAP was molecularly associated with Kir4.1, which was increased by HOC at 20 min; this increase was blocked by BaCl2. These results suggest that HOC‐evoked astrocytic retraction or decrease in the volume and length of its processes is associated with increased Kir4.1 activity. Kir4.1 involvement in HOC‐elicited astrocytic retraction is associated with AQP4 activity and GFAP plasticity, which together determines the rebound excitation of VP neurons.
Costs of dementia with lewy bodies: A Chinese multicenter cross‐sectional study
Authors: Guo Xia , Meng Qingbo , Zuo Meimei , Su Zhou , Gan Jinghuan , Li Xu‐Dong , Zhu Hongcan , Gang Baozhi , Niu Jinping , Liu Shuai , Ji Yong 
Published: November 2022

AbstractIntroductionDementia with Lewy bodies (DLB) significantly increases the economic burden on caregivers and society, but few studies have focused on the costs. This study aims to evaluate the current economic costs of DLB and its related factors.MethodsA total of 193 patients diagnosed with probable DLB were consecutively enrolled from 6 memory clinics between August 2017 to July 2021. Data were collected from August to December of 2021, patients' per capita annual economic costs related to DLB in the year preceding the interview were evaluated, and factors related to the costs were assessed using regression analysis.ResultsPatients with DLB led to per capita annual total costs of US $21,378.3 in 2021, with direct medical costs, direct non‐medical costs and indirect costs of US $3471.4, US $3946.4 and US $13,960.5, respectively, accounting for 16.2%, 18.5% and 65.3%, of total costs. Factors related to the costs of DLB showed that impairments in activities of daily living (ADL) and caregivers' subjective burden had a greater impact on the total, direct medical and indirect costs.ConclusionThe economic burden of DLB in China is huge, and indirect costs account for the largest proportion, serious impairment of the ADL and the subjective burden of caregivers, which possibly has a greater effect on costs. The substantial contributions made by family members and other unpaid caregivers of DLB should be fully recognized in strategic policy discussions and in case‐level planning and assessments.
Incidence and prognostic significance of receptor discordance between primary breast cancer and paired bone metastases
Authors: Lin Mingxi , Jin Yizi , Lv Hong , Hu Xichun , Zhang Jian 
Published: November 2022

AbstractER, PgR and HER‐2 status are the cornerstones of choosing systemic therapy for breast cancer, but can change during the disease course. Guidelines recommended the biopsy of the metastatic tumor to reassess receptor status. Bone is the most frequent metastatic site of breast cancer but remained technically difficult to biopsy. Our study aimed to evaluate the incidence and prognostic significance of receptor discordance between primary breast cancer and paired bone metastases. One hundred and fifty‐five breast cancer patients were diagnosed with pathology‐confirmed bone metastasis at Fudan University Shanghai Cancer Center. Ninety‐three patients with receptor status available on both primary tumor and bone metastases were included in our study. ER, PgR and HER‐2 status converted from positive to negative in 10.8% (10/93), 28.0% (26/93) and 8.6% (8/93) of the patients, while ER, PgR and HER‐2 status converted from negative to positive in 3.2% (3/93), 4.3% (4/93) and 1.1% (1/93) of the patients, respectively. 40.4% (17/42) of the HER2‐0 tumors converted to HER2‐low, which enabled them to receive the treatment of new antibody‐drug conjugates (ADCs). Prior endocrine and anti‐HER2 therapy were the independent risk factors for receptor conversion. Loss of HR expression in bone metastases was significantly associated with worse first‐line PFS (adjusted hazard ratio = 3.271, P‐value = .039) and OS (adjusted hazard ratio = 6.09, P‐value = .011). In conclusion, our study confirmed that patients may experience receptor conversion between primary breast cancer and bone metastases, possibly influenced by prior treatments, which significantly influenced prognosis. The rebiopsy of bone metastases in patients with primary HER2‐0 tumors may benefit from the new ADC drugs.
Conbercept improves macular microcirculation and retinal blood supply in the treatment of nonischemic branch retinal vein occlusion macular edema
Authors: Huang Yikeng , Linghu Minli , Hu Weiwen , Huang Xionggao 
Published: November 2022

AbstractPurposeTo investigate the effect of conbercept on macular microvascular system and retinal blood supply in the treatment of nonischemic branch retinal vein occlusion macular edema (BRVO‐ME).MethodsPatients were divided into three groups: group A (containing 12 nonischemic BRVO‐ME eyes), group B (containing contralateral 12 healthy eyes), and group C (containing 30 cataract eyes to obtain normal aqueous humor cytokine levels). Group A received monthly intravitreal injections of conbercept for 3 months. General data and best‐corrected visual acuity (BCVA) were compared among the three groups. Optical coherence tomography angiography (OCTA) results (including central macular thickness [CMT], retinal vascular density and perfusion, and foveal avascular zone [FAZ]) at baseline were compared among groups A and B. Aqueous humor cytokine levels (including VEGF, IL‐8, PDGF‐AA, TNF‐α, and ANGPTL‐4) at baseline were compared between groups A and C. Moreover, BCVA, OCTA results, and aqueous humor cytokine levels of group A before and after conbercept treatment were compared.ResultAt baseline, group A had a significantly worse BCVA, lower retinal vascular density and perfusion, and numerically larger CMT and FAZ area comparing to the group B, and had a higher aqueous cytokine level (IL‐8, VEGF, and ANGPTL‐4) comparing to the group C (all ps < 0.05). After the injection of conbercept, group A presented a better BCVA (at initial diagnosis vs. after three conbercept injections: 1.16 ± 0.51 vs. 0.81 ± 0.30, logMAR, p < 0.05), higher retinal vascular density (11.56 ± 4.73 vs. 15.88 ± 2.31, mm−1, p < 0.05) and perfusion (0.28 ± 0.12 vs. 0.39 ± 0.06, mm2, p < 0.05), smaller CMT (504.92 ± 184.11 vs. 219.83 ± 46.63, mm2, p < 0.05), as well as a lower levels of VEGF (before first injection vs. before third injection: 113.84 [70.81, 235.4] vs. 3.94 [3.56, 8.07], pg/ml, p < 0.05) and ANGPTL‐4 (45,761 [7327.5, 81,402.5] vs. 25,015.5 [6690, 43,396], pg/ml, p < 0.05). However, the average FAZ area of group A expanded (at initial diagnosis vs. after three conbercept injections: 0.41 ± 0.14 vs. 0.62 ± 0.36, mm2, p < 0.05).ConclusionThis study demonstrated that intraocular injection of conbercept could effectively improve macular microcirculation and increase retinal blood supply in the treatment of nonischemic BRVO‐ME based on the combination of visual acuity, OCTA parameters, and aqueous humor cytokine assay results. However, further study with a larger sample size and longer observation period is still needed in the future.
Termitomyces pakistanensis, a new mushroom species from Pakistan based on scanning electron microscopy and ITS‐rDNA barcoding
Authors: Razaq Abdul , Ishaq Aamna , Ilyas Sobia , Niaz Shereen , Sadia Sehrish 
Published: November 2022

AbstractTermitomyces pakistanensis sp. nov. is a member of an edible genus generally distributed in Asia and Europe. This species has been described as new species based on its different morphology, and scanning electron microscopy (SEM) of basidiospores. The novelty and degree of endemism is confirmed by analyzing the genetic variation of the internal transcribed spacer regions (ITS1–5.8 S–ITS2) of the ribosomal DNA gene, a universal fungal marker. The evolutionary affinities of new species is also evaluated with Asian and European species by phylogenetic analysis based on ITS sequences. In our phylogenetic analysis, this genus is found monophyletic comprising of two monophyletic sub clades: Clade I, Microcarpus, with small sized fruiting bodies generally less than 5 cm without pseudorrhiza and Clade II, Macrocarpus, with large sized fruiting bodies generally more than 5 cm having pseudorrhiza. All collections of Pakistani species clustered independently in Microcarpus clade showing their endemic genetic makeup as it is clustering independently. A comprehensive description, photographs of the basidiocarps and Scanning electron microscopy (SEM) micrographs of spores are provided.Research Highlights
It has a new species from Pakistan to world based on the scanning electron microscopy and further confirmed by DNA barcoding.
The exact shape and size of basidiospores of this novel species is first time introduced by using SEM analysis.
This genus is rarely described from Pakistan.
This paper has introduced a two clade, Microcarpus and macrocarpus, in the world for this genus.
Comparison of fiber reinforcing methods of composite resin: A flexural strength and stereo microscopy study
Authors: Cengiz Seda , Bagis Bora , Külünk Şafak , Velioğlu Neslin , Sağlam Gaye 
Published: November 2022

AbstractThis study aimed to compare the effect of fiber reinforcing methods on the flexural strength and failure modes of indirect composite resins. Based on the reinforcement methods, the bar specimens (3 × 3 × 25 mm) were divided into five groups (n = 20). Glass or polyethylene fibers were used for reinforcement of indirect composite resins. Fibers were either light polymerized and mixed with indirect composite resin or mixed with indirect composite resin after resin application and polymerized together. Indirect composite resin without fiber reinforcement was used as control. All five types of specimens were stored in distilled water at 37°C for 24 h. Half of the specimens were additionally thermocycled. Then the specimens were tested in a three‐point bending test. Failure types were examined and categorized by using stereo microscope. The data were analyzed using two‐way ANOVA and Tukey HSD test. Flexural strength was found to be significantly higher for fiber‐reinforced indirect resin composites than control. However, the fiber‐reinforced groups did not present any significant difference. Analysis revealed aging does not affect the flexure strength of fiber reinforcement of indirect composite resin. The study concluded that the flexure strength of indirect composite resins was improved with fiber reinforcement. Different fiber reinforcement methods demonstrated similar effects on the flexure strength of indirect composite resin. Reinforcement with glass or polyethylene fibers presented the potential to improve the mechanical properties of indirect composite resins.Research HighlightsFlexural strength of indirect composite resins are affected by the reinforcement of composites with glass or polyethylene fibers. Aging with thermocycling has no effect on the flexural strength of the indirect composite resins, however can cause catastrophic failures in material.