bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memberikan Pengetahuan dan Pencegahan Covid-19 di Desa Maripari Kecamatan Sukawening
Authors: Mauluddin Yusuf , Elyana Mela , Lutfhi AA , Ramadhan Rhafi Faisal , Fauzi Muhammad Irsan Rizki , Sidiq Yogi Hilman 
Published: October 2022

Kuliah Kerja Nyata (KKN) Sekolah Tinggi Teknologi Garut 2020 dimulai dari tanggal 1 Agustus sampai dengan 30 Agustus 2020 di Desa Maripari Kecamatan Sukawening. Tujuan utama KKN 2020 ini adalah untuk memberikan pengetahuan dan pencegahan Covid-19 pada masyarakat desa Maripari. Program yang dilaksanakan gi menjadi empat pokok kegiatan, yaitu meliputi kegiatan Literasi dengan materi Covid-19, pendataan dan kemanusian, peningkatan kapasitas dan pembuatan konten Covid-19. Hasil kegiatan literasi materi Covid-19 diantaranya adalah memberikan penyuluhan kepada masyarakat dan para pelajar. Hasil kegiatan bidang peningkatan kapasitas diantaranya mengidentifikasi usaha mikro kecil menengah, pendataan dan kemanusian melakukan pendataan mengenai profil desa Maripari dan juga melakukan kegiatan kemanusiaan dengan penyemprotan cairan disinfektan. Hasil dari pembuatan konten adalah kerja informasi tetang Covid-19 yang diunggah dalam media digital. Secara umum kegiatan yang dilaksanakan berjalan dengan baik berkat Kerjasama yang baik dengan aparat desa dan masyarakat.
Pemberdayaan Masyarakat Desa Karangsari Garut Berbasis Kesehatan, Infrastruktur dan Kewirausahaan di Masa Pandemi
Authors: Pariyatin Yeni , Rizki Reza Fauzabill , Syahputra Muh. Reza , Noviandi Hasbil Asfahani , Maulidan Ripan , Rahma Rima Agnia , Qodari Melani Nur Lailatul , Yuni Siti , Rosidin Ahmad , Mustofa Aji Nurul , Hidayat Agung Nurul 
Published: October 2022

Potensi di bidang perairan, bidang pertanian, dan bidang usaha juga fasilitas untuk protokol kesehatan sudah dimiliki oleh Desa Karangsari. Namun, masyarakat belum cukup baik dalam memanfaatkan potensi serta fasilitas tersebut. Hal ini dikarenakan kesadaran dan pengetahuan masyarakat masih kurang. Kuliah Kerja Nyata Tematik Daring 2021 Institut Teknologi Garut, bertujuan untuk memberikan kontribusi dalam memberdayakan masyarakat di masa pandemi covid-19 dengan memberikan pengetahuan atau edukasi melalui kegiatan seminar yang dilaksanakan secara online, yang bertema tentang pentingnya menjaga protokol kesehatan, pembangunan infrastruktur yang tepat dan pemanfaatan peluang usaha. Upaya tersebut dilaksanakan melalui beberapa tahapan dimulai dari mengidentifikasi masalah, peningkatan kapasitas melalui beberapa pelayanan webinar yang dilaksanakan serta evaluasi. Hasil pembahasan menunjukan bahwa kegiatan memberdayakan masyarakat dalam upaya peningkatan pengetahuan dan memberikan edukasi melalui kegiatan webinar secara umum mendapatkan tanggapan yang positif.
New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational prospective review
Authors: Raghav Alok , Singh Manish , Jeong Goo-Bo , Giri Richa , Agarwal Saurabh , Kala Sanjay 
Published: October 2022

BackgroundPeripheral nerve injury is a serious concern that leads to loss of neuronal communication that impairs the quality of life and, in adverse conditions, causes permanent disability. The limited availability of autografts with associated demerits shifts the paradigm of researchers to use biomaterials as an alternative treatment approach to recover nerve damage.PurposeThe purpose of this study is to explore the role of biomaterials in translational treatment approaches in diabetic neuropathy.Study designThe present study is a prospective review study.MethodsPublished literature on the role of biomaterials in therapeutics was searched for.ResultsBiomaterials can be implemented with desired characteristics to overcome the problem of nerve regeneration. Biomaterials can be further exploited in the treatment of nerve damage especially associated with PDN. These can be modified, customized, and engineered as scaffolds with the potential of mimicking the extracellular matrix of nerve tissue along with axonal regeneration. Due to their beneficial biological deeds, they can expedite tissue repair and serve as carriers of cellular and pharmacological treatments. Therefore, the emerging research area of biomaterials-mediated treatment of nerve damage provides opportunities to explore them as translational biomedical treatment approaches.ConclusionsPre-clinical and clinical trials in this direction are needed to establish the effective role of several biomaterials in the treatment of other human diseases.
Preoperative voice analysis and survival outcomes in papillary thyroid cancer with recurrent laryngeal nerve invasion
Authors: Chen Jiaming , Zhong Qi , Hou Lizhen , Ma Hongzhi , Shi Qian , Feng Ling , He Shizhi , Lin Yansong , Lian Meng , Shen Xixi , Wang Ru , Fang Jugao 
Published: October 2022

ObjectiveTo investigate the clinicopathological characteristics of papillary thyroid cancer (PTC) and identify risk factors for postoperative recurrence of PTC with recurrent laryngeal nerve (RLN) involvement.MethodsIn total, 171 patients (112 women and 59 men, age: 18–80 years, and 65 patients aged ≥ 55) with T4a PTC with RLN involvement, treated at Beijing Tongren Hospital, Capital Medical University, from January 2006 to December 2020, were retrospectively examined. Clinicopathological characteristics, including voice analysis results, and survival outcomes were assessed. The Mann–Whitney U and Kruskal–Wallis H tests were used to analyze differences in acoustic parameters. The Kaplan–Meier method was used to calculate the overall survival (OS) and recurrence-free (RFS) rates. Univariate and multivariate Cox regression analyses were performed of the clinical data.ResultsThe postoperative follow-up period ranged from 12 to 196 months (mean: 66.18 months). Of the 171 patients, 16 had recurrence and 8 died of thyroid-related diseases. The 5-year OS rate was 95.22%. The 5-year RFS rate was 89.38%. Jitter and shimmer were higher and maximum phonation time was shorter in patients with preoperative vocal cord paralysis (VCP) than in those without RLN involvement, and in those with RLN involvement but without preoperative VCP. Acoustic parameters were similar in patients with no preoperative VCP and those without RLN involvement. Voice analysis results did not differ between cases with RLN adhesion and RLN invasion. Univariate analysis showed that age at onset ≥ 55 years, preoperative RLN palsy, and esophageal invasion were risk factors for postoperative recurrence of PTC with RLN involvement. Multivariate analysis showed that onset age ≥ 55 years (OR 4.52, 95% confidence interval: 1.44–14.19, P = 0.010) was an independent risk factor for recurrence.ConclusionsPTC patients with RLN invasion can achieve good outcomes. Preoperative voice analysis may offer insights into RLN function. Age of onset ≥ 55 years is an independent risk factor for postoperative recurrence in T4a PTC patients.
Comparison of serum cytokines levels in normal-weight and overweight patients with first-episode drug-naïve major depressive disorder
Authors: Gao Wenfan , Xu Yayun , Liang Jun , Sun Yanhong , Zhang Yuanyuan , Shan Feng , Ge Jinfang , Xia Qingrong 
Published: October 2022

ObjectiveAbnormal levels of blood cytokines have been demonstrated to be associated with both excess weight and major depressive disorder (MDD). However, few studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in individuals with first-episode drug-naïve MDD.MethodsA total of 49 patients with first-episode drug-naïve MDD were categorized into normal weight (18.5 ≤ BMI &lt; 25 kg/m2) and overweight (25 ≤ BMI &lt; 30 kg/m2) groups according to WHO-criteria. The severity of depressive symptoms was assessed using the 24-items Hamilton Depression Scale (HAMD-24). A total of 37 cytokines were measured using Multiplex Luminex Assays. The scores of HAMD-24 and the levels of serum cytokines between normal weight group and overweight group were compared. Multiple linear regression analysis was performed to evaluate the association between abnormal serum cytokines levels and group after adjusting for HAMD-24 scores. The correlation between BMI and the scores of HAMD-24 and the levels of serum cytokines was evaluated using Pearson correlation analysis.ResultsThe scores of HAMD-24 in overweight group were significantly higher than normal weight group (t = -2.930, P = 0.005). Moreover, the levels of IL-1α, IL-1RA, IL-3, CXCL10, TNF-α, and ICAM-1 in overweight patients with MDD were significantly higher than those in normal-weight patients with MDD (all P &lt; 0.05). Furthermore, after adjustment for HAMD-24 scores, there was a significant correlation between abnormal serum cytokines levels (IL-1α, IL-1RA, IL-3, CXCL10, TNF-α, and ICAM-1) and group (all P &lt; 0.05). Additionally, BMI was positively correlated to the serum levels of IL-1α (r = 0.428, P = 0.002), IL-3 (r = 0.529, P &lt; 0.001), IL-6 (r = 0.285, P = 0.050), IL-10 (r = 0.423, P = 0.003), IL-12 (r = 0.367, P = 0.010), IL-15 (r = 0.300, P = 0.036), CXCL10 (r = 0.316, P = 0.030), TNF-α (r = 0.338, P = 0.021), and ICAM-1 (r = 0.440, P = 0.002) in MDD patients.ConclusionsThese results provide direct evidence, probably for the first time, that overweight may be associated with several serum cytokines in patients with first-episode drug-naïve MDD. The underlying mechanisms are unclear and require further investigation.
Plasma acylcarnitine and diabetic retinopathy: A study from Eastern China
Authors: Jin Dongzhen , Zhao Shuzhen , Li Huihui , Xia Zhezheng , Che Mingzhu , Huang Ruogu , Lai Mengyuan , Wang Yanan , Zhang Zejie , Wang Hui , Zuo Jingjing , Zheng Chao , Mao Guangyun 
Published: October 2022

Background and purposeAcylcarnitines (ACars) are important for insulin resistance and type 2 diabetes (T2D). However, their roles in diabetic retinopathy (DR) remain controversial. In this study, we aimed to investigate the association of ACars with DR and their values in DR detection.MethodsThis was a two-center case-control study based on the propensity score matching approach between August 2017 to June 2018 in Eastern China. Multivariable logistic regression models were applied to estimate the association of plasma ACars with DR. Differential ACars were screened by models of least absolute shrinkage and selection operator, elastic net, and weighted quantile sum regression, and their roles in DR identification were further evaluated by the area under the receiver operating curve (AUC).ResultsEight of twenty plasma ACars (8:0, 12:0, 12:1, 14:1, 16:2, 18:0, 18:2 and 18:3) were associated with DR, while only ACar 8:0 was selected by three variable selection methods. As compared to those with the 1st tertile of ACar 8:0, the adjusted odds ratio (OR) and 95% confidence interval (CI) of DR were 0.22 (0.08, 0.59) and 0.12 (0.04, 0.36) for subjects in the 2nd and 3rd tertiles, respectively (P for trend &lt; 0.001). Consistent associations were also observed in both restricted cubic spline regression models and subgroup analyses. AUC (95% CI) were 0.74 (0.66, 0.82) for ACar 8:0 alone and 0.77 (0.70, 0.85) for ACar 8:0 combined with covariates.ConclusionsOur findings suggest higher ACar 8:0 is significantly associated with a decreased risk of DR, which provides a unique window for early identification of DR.
A novel signature based on pyroptosis-related genes for predicting prognosis and treatment response in prostate cancer patients
Authors: Xiao Xi , Li Jianpeng , Wan Shun , Wu Mingzhe , Li Zonglin , Tian Junqiang , Mi Jun 
Published: October 2022

Background: Pyroptosis is a form of programmed cell death accompanied by specific inflammatory and immune responses, and it is closely related to the occurrence and progression of various cancers. However, the roles of pyroptosis-related genes (PRGs) in the prognosis, treatment response, and tumor microenvironment (TME) of prostate cancer (PCa) remain to be investigated.Methods: The mRNA expression data and clinical information of PCa patients were obtained from the Cancer Genome Atlas database (TCGA) and the cBioPortal for Cancer Genomics website, and the 52 PRGs were obtained from the published papers. The univariate, multivariate, and LASSO Cox regression algorithms were used to obtain prognostic hub PRGs. Meanwhile, qRT-PCR was used to validate the expression of hub genes between PCa lines and normal prostate epithelial cell lines. We then constructed and validated a risk model associated with the patient’s disease-free survival (DFS). Finally, the relationships between risk score and clinicopathological characteristics, tumor immune microenvironment, and drug treatment response of PCa were systematically analyzed.Results: A prognostic risk model was constructed with 6 hub PRGs (CHMP4C, GSDMB, NOD2, PLCG1, CYCS, GPX4), and patients were divided into high and low-risk groups by median risk score. The risk score was confirmed to be an independent prognostic factor for PCa in both the training and external validation sets. Patients in the high-risk group had a worse prognosis than those in the low-risk group, and they had more increased somatic mutations, higher immune cell infiltration and higher expression of immune checkpoint-related genes. Moreover, they were more sensitive to cell cycle-related chemotherapeutic drugs and might be more responsive to immunotherapy.Conclusion: In our study, pyroptosis played a significant role in the management of the prognosis and tumor microenvironment of PCa. Meanwhile, the established model might help to develop more effective individual treatment strategies.
Distinct immune and inflammatory response patterns contribute to the identification of poor prognosis and advanced clinical characters in bladder cancer patients
Authors: Chang Zhenglin , Li Rongqi , Zhang Jinhu , An Lingyue , Zhou Gaoxiang , Lei Min , Deng Jiwang , Yang Riwei , Song Zhenfeng , Zhong Wen , Qi Defeng , Duan Xiaolu , Li Shujue , Sun Baoqing , Wu Wenqi 
Published: October 2022

Due to the molecular heterogeneity, most bladder cancer (BLCA) patients show no pathological responses to immunotherapy and chemotherapy yet suffer from their toxicity. This study identified and validated three distinct and stable molecular clusters of BLCA in cross-platform databases based on personalized immune and inflammatory characteristics. H&amp;E-stained histopathology images confirmed the distinct infiltration of immune and inflammatory cells among clusters. Cluster-A was characterized by a favorable prognosis and low immune and inflammatory infiltration but showed the highest abundance of prognosis-related favorable immune cell and inflammatory activity. Cluster-B featured the worst prognosis and high immune infiltration, but numerous unfavorable immune cells exist. Cluster-C had a favorable prognosis and the highest immune and inflammatory infiltration. Based on machine learning, a highly precise predictive model (immune and inflammatory responses signature, IIRS), including FN1, IL10, MYC, CD247, and TLR2, was developed and validated to identify the high IIRS-score group that had a poor prognosis and advanced clinical characteristics. Compared to other published models, IIRS showed the highest AUC in 5 years of overall survival (OS) and a favorable predictive value in predicting 1- and 3- year OS. Moreover, IIRS showed an excellent performance in predicting immunotherapy and chemotherapy’s response. According to immunohistochemistry and qRT-PCR, IIRS genes were differentially expressed between tumor tissues with corresponding normal or adjacent tissues. Finally, immunohistochemical and H&amp;E-stained analyses were performed on the bladder tissues of 13 BLCA patients to further demonstrate that the IIRS score is a valid substitute for IIR patterns and can contribute to identifying patients with poor clinical and histopathology characteristics. In conclusion, we established a novel IIRS depicting an IIR pattern that could independently predict OS and acts as a highly precise predictive biomarker for advanced clinical characters and the responses to immunotherapy and chemotherapy.
Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review
Authors: Ambrożej Dominika , Makrinioti Heidi , Whitehouse Abigail , Papadopoulos Nikolas , Ruszczyński Marek , Adamiec Aleksander , Castro-Rodriguez Jose A. , Alansari Khalid , Jartti Tuomas , Feleszko Wojciech 
Published: October 2022

It has become clear that severe bronchiolitis is a heterogeneous disease; even so, current bronchiolitis management guidelines rely on the one-size-fits-all approach regarding achieving both short-term and chronic outcomes. It has been speculated that the use of molecular markers could guide more effective pharmacological management and achieve the prevention of chronic respiratory sequelae. Existing data suggest that asthma-like treatment (systemic corticosteroids and beta2-agonists) in infants with rhinovirus-induced bronchiolitis is associated with improved short-term and chronic outcomes, but robust data is still lacking. We performed a systematic search of PubMed, Embase, Web of Science, and the Cochrane’s Library to identify eligible randomized controlled trials to determine the efficacy of a personalized, virus-dependent application of systemic corticosteroids in children with severe bronchiolitis. Twelve studies with heterogeneous methodology were included. The analysis of the available results comparing the respiratory syncytial virus (RSV)-positive and RSV-negative children did not reveal significant differences in the associatons between systemic corticosteroid use in acute episode and duration of hospitalization (short-term outcome). However, this systematic review identified a trend of the positive association between the use of systematic corticosteroids and duration of hospitalization in RSV-negative infants hospitalized with the first episode of bronchiolitis (two studies). This evidence is not conclusive. Taken together, we suggest the design for future studies to assess the respiratory virus type in guiding predictive enrichment approaches in infants presenting with the first episode of bronchiolitis.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42020173686
Effect of the change in antiviral therapy indication on identifying significant liver injury among chronic hepatitis B virus infections in the grey zone
Authors: Ren Shan , Wang Wenjing , Lu Junfeng , Wang Kefei , Ma Lina , Zheng Yanhong , Zheng Sujun , Chen Xinyue 
Published: October 2022

ObjectiveIn clinical practice, a substantial proportion of chronic hepatitis B virus (HBV) infections that do not fit into any of the usual immune states are considered to be in the “grey zone (GZ)”. This study aimed to investigate the effect of the change in antiviral therapy indication on identifying significant hepatic injury among GZ patients.MethodsPatients with chronic HBV infections and a persistent normal alanine aminotransferase (ALT) level (PNALT) who underwent ultrasonography-guided percutaneous liver biopsy were examined retrospectively. Evidenced hepatic injury (EHI) was defined as an inflammation grade ≥2 (≥G2) and/or fibrosis stage ≥2 (≥F2). Complete clinical data, liver inflammation, and fibrosis grades were collected, and the levels of cytokines were detected by the Luminex technique, all of which were analysed to investigate the immune and histopathology states of the liver.ResultsA total of 347 patients with chronic HBV infections and PNALT were categorized into immune tolerant (IT, n = 108), inactive HBV surface antigen (HBsAg) carrier (IHC, n = 61), GZ-1 (HBeAg positive in GZ, n = 92), and GZ-2 (HBeAg negative in GZ, n = 68) phases. Among them, 51.3% were in the GZ phase, and 50.1% presented with EHI. The IL-6 levels were higher in the EHI group than in the non-EHI group (2.77 vs. 1.53 pg/ml, Z = −13.32, p = 0.028). The monocyte chemoattractant protein 1 (MCP-1) level was positively correlated with HBV DNA (R = 0.64, p &lt; 0.001) and HBeAg (R = 0.5, p &lt; 0.001) but negatively correlated with fibrosis grade (R = −0.26, p = 0.048). The ratio of EHI in the GZ phase was 60.55%, which was significantly higher than that in patients in the IT (39.8%) and IHC phases (37.7%) (χ2 = 10.4, p = 0.006). A total of 46.69% of all patients exceeded the new ALT antiviral treatment threshold (30 U/L for men and 19 U/L for women). The EHI values in the IT and IHC phases below the new ALT threshold were 32.6% and 37.8%, respectively, whereas higher EHI values of 67.4% and 68.4% were seen in GZ-1 and GZ-2 patients, respectively, exceeding the new ALT threshold, and the difference was statistically significant (χ2 = 11.13, p &lt; 0.001; χ2 = 14.22, p = 0.002). The median age in our cohort was 38.91 years, and only 21.03% were less than 30 years old. The EHI values in the IT and IHC patients &lt;30 years old were 32.4% and 35.8%, respectively, while the ratio of EHI increased to 43.2% once patients were older than 30 years but still in the IT and IHC stages.ConclusionSetting 30 years old as a cut-off and lowering the ALT threshold could facilitate screening for the presence of significant liver injury, especially for GZ patients. IL-6 was a good indicator of EHI, and MCP-1 was significantly positively correlated with HBV DNA but negatively correlated with liver fibrosis.
Haploidentical donor stem cell transplantation had a lower incidence of bronchiolitis obliterans syndrome compared with HLA-matched sibling donor transplantation in patients with hematologic malignancies: Benefit from ATG?
Authors: Weng Guangyang , Fan Zhiping , Xue Huiwen , Huang Fen , Xu Na , Jin Hua , Yu Sijian , Ye Zhixin , Fan Jingchao , Xuan Li , Liu Qifa 
Published: October 2022

BackgroundHaploidentical donor stem cell transplantation (HID-SCT) based on antithymocyte globulin (ATG) for graft-versus-host disease (GVHD) prophylaxis had achieved a similar incidence of chronic graft-versus-host disease (cGVHD) with human leukocyte antigen (HLA)-matched sibling donor stem cell transplantation (MSD-SCT). However, bronchiolitis obliterans syndrome (BOS), which serves as pulmonary cGVHD, was rarely compared between HID and MSD transplantation.MethodsOne thousand four hundred five patients with hematologic malignancies who underwent allogeneic SCT were enrolled in this retrospective study. Based on donor type, we divided the patients into three groups: HID, MSD, and match unrelated donor (MUD) groups. The cumulative incidences and risk factors of BOS were analyzed.ResultsThe 5-year cumulative incidence of BOS was 7.2% in the whole population. HID transplantation had a lower 5-year cumulative incidence of BOS than MSD transplantation (4.1% vs. 10.0%, p &lt; 0.001) and a similar incidence with MUD transplantation (4.1% vs. 6.2%, p = 0.224). The 5-year cumulative incidence of BOS was lower in the ATG group than that in the non-ATG group in both the whole and MSD populations (4.6% vs. 11.2%, p &lt; 0.001, and 4.1% vs. 11.2%, p = 0.042, respectively). The 5-year incidence of BOS in mixed grafts [peripheral blood stem cell (PBSC) plus bone marrow] group was also lower than that in the PBSC group (4.2% vs. 9.1, p = 0.001). Multivariate analysis showed that HID, ATG, and mixed grafts were protective factors for BOS [odds ratio (OR) 0.3, 95% CI 0.2–0.6, p &lt; 0.001; OR 0.3, 95% CI 0.2–0.7, p = 0.001; OR 0.3, 95% CI 0.1–0.8, p = 0.013], and acute graft-versus-host disease (aGVHD) and cGVHD were independent risk factors for BOS (OR 2.1, 95% 1.1–4.3, p = 0.035; OR 10.1, 95% CI 4.0–25.0, p &lt; 0.001).ConclusionsHID transplantation had a lower incidence of BOS than MSD transplantation, which might be associated with ATG and mixed grafts.