bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemodelan Pola Sedimentasi di Muara Cisadane untuk Mendukung Pengembangan Terpadu Pesisir Ibukota Negara
Authors: Wibowo Mardi , Khoirunnisa Hanah , Wardhani Khusnul Setia , Wijayanti Reni 
Published: June 2022

NCICD is one of the national strategic programs to deal with coastal problems in Jakarta. One alternative structure to be built is WLP or known as coastal resort. As an initial step to make it happen, BAPPENAS plans to build a WLP pilot plan around the S. Cisadane estuary. One of the main considerations for designing the WLP layout is the process and pattern of sedimentation around the Cisadane estuary. Therefore, computational modeling of sediment transport around the Cisadane estuary was carried out for a period of 1 year (August 2020-July 2021). This modeling uses MIKE-21 module MIKE21/3 Integrated Models software which combines hydrodynamics and cohesive sediment transport models. Based on the results of this modeling, it is known that there are differences in sediment transport patterns in the west and east monsoons. During 1 year, changes in the thickness of the bottom sediment around the estuary of S. Cisadane ranged from -0.4 to 0.7 m with a mean of 0.086 m. Coastal reservoir design must take into the very dynamic sedimentation process around the Cisadane estuary. Pengembangan Terpadu Pesisir Ibukota Negara (PTPIN) merupakan salah satu program strategis nasional untuk menangani permasalahan pesisir di Jakarta. Salah satu alternatif struktur yang akan dibangun adalah WLP atau dikenal sebagai coastal reservoir. Sebagai langkah awal mewujudkannya BAPPENAS merencanakan membangun pilot plan WLP di sekitar muara S. Cisadane. Salah satu pertimbangan utama untuk mendesain layout WLP adalah proses dan pola sedimentasi di sekitar muara Cisadane. Oleh karena itu dilakukan pemodelan komputasi transpor sedimen di sekitar muara Cisadane selama kurun waktu 1 tahun (Agustus 2020-Juli 2021). Pemodelan ini menggunakan software MIKE-21 module MIKE21/3 Integrated Models yang menggabungkan model hidrodinamika dan transpor sedimen kohesif. Berdasarkan hasil pemodelan ini diketahui bahwa terdapat perbedaan pola transpor sedimen di musim barat dan musim timur. Selama 1 tahun, perubahan ketebalan sedimen dasar di sekitar muara S. Cisadane berkisar -0,4-0,7 m dengan rerata 0,086 m. Pola sedimentasi yang sangat dinamis harus mendapatkan perhatian khusus dalam merancang waduk lepas pantai.
Korelasi Klorofil-a dengan Nutrien dan Kualitas Perairan di Pulau Seruni Karimunjawa Indonesia
Authors: Widiaratih Rikha , Suryoputra Agus Anugroho Dwi , Handoyo Gentur 
Published: June 2022

Seruni Island is one of the islands located in the easternmost and is an uninhabited island in Karimunjawa, Jepara Regency, Central Java. Seruni Island has a tourist attraction, namely a stretch of white sand, coral reefs, and which is currently used by local people for seaweed cultivation. There are still many tourism opportunities and marine utilization that have not been utilized optimally. Knowing the availability of chlorophyll-a and its correlation with nutrients (ammonia, nitrate, and phosphate) and water quality on Seruni Island can provide an initial overview of the fertility conditions of the waters on Seruni Island so that other marine utilization opportunities can be wide opened. In situ data are collected such as seawater samples, which are then analyzed in the laboratory, as well as water quality parameters including salinity, pH, DO, temperature and brightness. Although Seruni Island is an uninhabited island, however, it is possible that there will be runoff from the surrounding inhabited islands, which will increase the concentration of chlorophyll-a. The results showed that chlorophyll-a had a high and negative correlation with nutrients, namely ammonia (r=-0.985), and water quality, namely temperature and brightness (r=-0.895 and r=-0.734). Pulau Seruni merupakan salah satu pulau yang lokasinya terletak paling timur dan merupakan pulau tidak berpenghuni di Karimunjawa, Kabupaten Jepara Jawa Tengah. Pulau Seruni memiliki daya tarik wisata yaitu hamparan pasir putih, terumbu karang, dan yang saat ini dimanfaatkan masyarakat setempat untuk budidaya rumput laut. Masih banyak peluang wisata dan pemanfaatan bahari yang belum dimanfaatkan secara optimal. Dengan mengetahui ketersediaan klorofil-a dan korelasinya terhadap nutrien (ammonia, nitrat dan fosfat) dan kualitas perairan di Pulau Seruni dapat memberikan gambaran awal terkait kondisi kesuburan perairan yang ada di Pulau Seruni, sehingga dapat terbuka peluang pemanfaatan bahari lainnya. Data in situ yang diambil berupa sampel air laut, yang selanjutnya dianalisis di laboratorium, serta parameter kualitas perairan meliputi salinitas, pH, DO, suhu dan kecerahan. Walaupun Pulau Seruni merupakan pulau yang tidak berpenghuni, namun demikian tidak menutup kemungkinan terdapat limpasan massa air yang berasal dari pulau sekitarnya yang berpenghuni yang berdampak pada meningkatnya konsentrasi klorofil-a. Hasil penelitian menunjukkan klorofil-a memiliki korelasi yang tinggi dan bernilai negatif dengan nutrient, yaitu ammonia (r=-0,985), dan kualitas perairan yaitu suhu dan kecerahan (r=-0,895 dan r=-0,734). Kata kunci : klorofil-a, nutrient, kualitas perairan, Korelasi, P.Seruni
Evaluation of fractures using conventional and FMI logs, and 3D seismic interpretation in continental tight sandstone reservoir
Authors: Qiu Xiangliang , Tan Chengqian , Lu Yuanyuan , Yin Shuai 
Published: June 2022

Abstract
Due to the complex pore structures and strong heterogeneity of fractured reservoirs, it is a hot and difficult point in petroleum geology to identify fractures using logging principles. In this paper, taking the tight sandstone reservoir of the Chang 8 Member in the Huanjiang Oilfield as an example, field outcrops, cores, thin sections, and logging identification methods were used for quantitative description and fine logging evaluation of fractures. The research shows that high-angle, medium-low-angle, near-vertical, and horizontal fractures are developed in the Chang 8 Member of the Huanjiang Oilfield. The main ones are high-angle fractures, followed by horizontal fractures with a low degree of fillings. Under the constraints of core and imaging logging data, three fracture sensitivity logging parameters of acoustic wave time difference, natural gamma, and dual induction-octalateral resistivity were optimized, and a comprehensive fracture probability index was proposed. Seventy-nine fracture development intervals were identified based on log curve characteristics and fracture probability indexes. The coincidence rate of fracture logging identification results with the core observation and imaging logging interpretation is 80.6%. The research results can provide a theoretical basis for the efficient development of fractured continental tight sandstone reservoirs in similar areas.
Quantitatively determine the dominant driving factors of the spatial-temporal changes of vegetation-impacts of global change and human activity
Authors: Wang ShiJun , Ping Chang , Wang Ning , Wen Jing , Zhang Ke , Yuan Kun , Yang Jun 
Published: June 2022

Abstract
The differences in spatial-temporal distribution patterns and dominant driving factors of vegetation evolution among sub-regions during different historical periods were not clear. Therefore, this study introduced the gravity center model and geodetector to analyze the spatial-temporal change characteristics and dominant driving factors of normalized difference vegetation index (NDVI) in China during 1981–2019 from the perspective of geographic divisions. Results showed that (1) during 1981–2019, the average vegetation coverage in China showed an increasing trend and zones with obviously increasing vegetation NDVI were mainly distributed in the middle reaches of the Yellow River basin and the upper reaches of the Yangtze River. (2) During 1981–2019, the gravity center of national vegetation NDVI was mainly concentrated in Yan’an City and Tongchuan City, showing a southward migration trend as a whole, which indicates that the increment and growth rates of the southern part were greater than those of the northern part. (3) The growth of vegetation in southern China was primarily affected by the temperature, while that of northern China was largely influenced by precipitation. (4) During 1981–2019, the dominant interactive factors of vegetation change for all subregions changed greatly: natural factor (climate or terrain) ∩ other factors → landuse ∩ other factors.
Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)
Authors: Hart Jessica M. , Hakim Joe B. , Wylie Blair J. , Beam Andrew L. 
Published: June 2022

Abstract

Objectives
To describe regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP).

Methods
Retrospective cohort study of a large, US commercial managed care plan claims database with pharmacy coverage from 2008 to 2018. Singleton pregnancies with at least one prior spontaneous preterm birth (sPTB) were included. Regional and state-based differences in 17-OHP use were compared. Data were analyzed using t-tests and Fisher’s exact tests.

Results
Of the 4,514 individuals with an indication for 17-OHP, 580 (12.8%) were prescribed 17-OHP. Regional and state-based differences in 17-OHP utilization were identified; Northeast 15.7%, Midwest 13.7%, South 12.0%, and West 10.4% (p=0.003).

Conclusions
While significant regional differences in 17-OHP utilization were demonstrated, 17-OHP utilization remained low despite this cohort having insurance through a US commercial managed care plan. Suboptimal utilization demonstrates a disconnect between research and uptake in clinical practice. This underscores a need for implementation science in obstetrics to translate updated recommendations more effectively and efficiently into clinical practice.
Nietzsche als Leser
Authors: von Seggern Hans-Gerd 
Published: June 2022

Abstract

Nietzsche as Reader.
This collective review summarizes and critically reflects on the results of four recent publications. On the one hand, this involves a typology of the specific mode of reception with which Nietzsche often incorporates seemingly selective readings into his thought and subsequently allows them to become productive in his writings; on the other hand, I am also dealing with the exceptional importance of Italian philology for current research into the influences on Nietzsche. The German-Italian conference volume Corrispondenze estetiche focuses on Heinrich Heine’s influence, but it also discusses in a sophisticated way the tension between the two authors in the context of the history of nineteenth-century aesthetics. Vivetta Vivarelli’s study discusses the motif of eternal recurrence in various references to contemporary poetry, while Benedetta Zavatta presents the ultimate study of Nietzsche’s reading of Ralph Waldo Emerson.
Synthesis, characterization, and theoretical investigation of 4-chloro-6(phenylamino)-1,3,5-triazin-2-yl)asmino-4-(2,4-dichlorophenyl)thiazol-5-yl-diazenyl)phenyl as potential SARS-CoV-2 agent
Authors: Eno Ededet A. , Louis Hitler , Unimuke Tomsmith O. , Egemonye ThankGod C. , Adalikwu Stephen A. , Agwupuye John A. , Odey Diana O. , Abu Abu Solomon , Eko Ishegbe J. , Ifeatu Chukwudubem E. , Ntui Tabe N. 
Published: June 2022

Abstract
The synthesis of 4-chloro-6(phenylamino)-1,3,5-triazin-2-yl)amino-4-(2,4 dichlorophenyl)thiazol-5-yl-diazenyl)phenyl is reported in this work with a detailed structural and molecular docking study on two SARS-COV-2 proteins: 3TNT and 6LU7. The studied compound has been synthesized by the condensation of cyanuric chloride with aniline and characterized with various spectroscopic techniques. The experimentally obtained spectroscopic data has been compared with theoretical calculated results achieved using high-level density functional theory (DFT) method. Stability, nature of bonding, and reactivity of the studied compound was evaluated at DFT/B3LYP/6-31 + (d) level of theory. Hyper-conjugative interaction persisting within the molecules which accounts for the bio-activity of the compound was evaluated from natural bond orbital (NBO) analysis. Adsorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties of the experimentally synthesized compound was studied to evaluate the pharmacological as well as in silico molecular docking against SARS-CoV-2 receptors. The molecular docking result revealed that the investigated compound exhibited binding affinity of −9.3 and −8.8 for protein 3TNT and 6LU7 respectively. In conclusion, protein 3TNT with the best binding affinity for the ligand is the most suitable for treatment of SARS-CoV-2.
Process intensification and digital twin – the potential for the energy transition in process industries
Authors: Huynh Thien An , Zondervan Edwin 
Published: June 2022

Abstract
The work defines and discusses process intensification (PI) and digital twin (DT) as potential tools to accelerate the energy transition through their applications in the process industries. The PI technologies take advantage of innovative principles in equipment design and control to improve the physical process, while the DT offers the virtual model of the plant as an environment for production optimization. The effects of both tools on the energy transition are evaluated not only from the point of applications but also from the possibility of implementation and barriers in process industries. Although they are beneficial, the deployment of PI and DT requires not only infrastructure and capital investment but the knowledge and cooperation of different levels of plant personnel. Besides review of individual implementation, this work explores the concept of combining PI and DT which can make them the enabler of each other and bring a breakthrough in optimization of process design and control.
Statistical damage constitutive model for the two-component foaming polymer grouting material
Authors: Du Mingrui , Wang Zhenyang , Fang Hongyuan , Li Manjun , Zhao Peng 
Published: June 2022

Abstract
Two-component foaming polymer (TFPU) grouting material is increasingly used in civil engineering. Its compressive strength is key to achieving the desired enhancing effect. The constitutive model of TFPU grouting material is a theoretical basis to evaluate the strength performance, which, however, is not fully understood. Here the uniaxial compression experiment of TFPU samples of different densities (0.11–0.53 g·cm−3) was conducted. Based on the stress–strain curves, the damage evolution equation of each sample was obtained by function fitting, followed by the establishment of statistical damage constitutive model. The model was simplified to a universal function with density as the argument. Results show that the stress–strain curves contain the initial compression stage, linear elastic stage, yield stage, yield plateau stage, and strain hardening stage regardless of the varied density. The variation laws of the damage with strain conform to the form of first-order decay exponential function. The theoretical stress–strain curves are in good agreement with the experimental ones, indicating that the statistical damage constitutive model can well reflect the mechanical behavior of TFPU grouting material. With this constitutive model, the mechanical properties of TFPU grouting material can be obtained according to the density alone, which is more convenient for practical engineering applications.
Metal organic frameworks (MOFS) as non-viral carriers for DNA and RNA delivery: a review
Authors: Soriano-Giles Gabriela , Giles-Mazón Edwin A. , Lopez Nazario , Reinheimer Eric , Varela-Guerrero Victor , Ballesteros-Rivas María F. 
Published: June 2022

Abstract
Metal-Organic Frameworks (MOFs) are a class of crystalline materials that, thanks to their large surface area and high porosity, allow them to be used in various areas of knowledge. This diversity of applications is due to the metal ions and the organic binders that compose them, but it is also important to highlight the ability of MOFs to function as hosts for a great variety of molecules of very different sizes and chemical properties. The first existing approaches for incorporating biomolecules in MOFs are discussed: pore encapsulation, surface binding, covalent binding, and in-situ encapsulation. Next, we discuss the obstacles of designing MOFs for effective gene delivery and how to enhance the gene delivery using different strategies.
Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring
Authors: Xue Lamei , Sun Juan , Liu Jinxin , Hu Chaoping , Wu Dandan , Nie Chenzhipeng , Zhang Kuiliang , Wang Yu , Zhao Lei , Li Xihua , Lu Yan , Zhang Li , Zhang Duo , Fan Mingcong , Qian Haifeng , Jiang Haowen , Wong Jiemin , Li Yuying , Ying Hao , Chow Billy KC , Wang Li , Li Yan 
Published: June 2022

AbstractOur knowledge of the coordination of intergenerational inheritance and offspring metabolic reprogramming by gastrointestinal endocrine factors is largely unknown. Here, we showed that secretin (SCT), a brain‐gut peptide, is downregulated by overnutrition in pregnant mice and women. More importantly, genetic loss of SCT in the maternal gut results in undesirable phenotypes developed in offspring including enhanced high‐fat diet (HFD)‐induced obesity and attenuated browning of inguinal white adipose tissue (iWAT). Mechanistically, loss of maternal SCT represses iWAT browning in offspring by a global change in genome methylation pattern through upregulation of DNMT1. SCT functions to facilitate ubiquitination and degradation of DNMT1 by activating AMPKα, which contributes to the observed alteration of DNMT1 in progeny. Lastly, we showed that SCT treatment during pregnancy can reduce the development of obesity and improve glucose tolerance and insulin resistance in offspring of HFD‐fed females, suggesting that SCT may serve as a novel biomarker or a strategy for preventing metabolic diseases.
Aplikasi Penghitung Jarak dan Jumlah Orang Berbasis YOLO Sebagai Protokol Kesehatan Covid-19
Authors: Indaryanto Faizal , Nugroho Anan , Suni Alfa Faridh 
Published: June 2022

Pandemi Covid-19 saat ini cukup memberikan dampak pada masyarakat. Skala penyebaran dari Covid-19 sangatlah cepat, sehingga membutuhkan penanganan yang benar. Salah satu cara untuk mengurangi penyebaran Covid-19 adalah dengan melakukan Social Distancing. Namun masyarakat cenderung lalai dalam melaksanakan protokol kesehatan tersebut. Salah satu cara untuk mengatasi masalah ini adalah dengan aplikasi social distancing detector yaitu aplikasi yang digunakan untuk mendeteksi jumlah dan jarak dari objek manusia yang ada pada satu area. Penelitian ini bertujuan untuk mengembangkan aplikasi social distancing detector menggunakan bahasa pemrograman Python dengan library YOLOv3. YOLOv3 memiliki kelebihan dalam object detection dengan akurasi yang tinggi yaitu diatas 90%. Pengujian metode pada penelitian ini menggunakan lima dataset pejalan kaki dari kamera pengawas jalan yang didapatkan dari dataset uji coba beberapa peneliti melalui Github yang memiliki resolusi yang baik dan memiliki objek manusia yang heterogen. Hasil akurasi dari deteksi citra pertama adalah 83,32%. Hasil akurasi dari deteksi citra kedua adalah 76,92%. Hasil akurasi dari deteksi citra ketiga adalah 89,99%. Hasil akurasi dari deteksi citra keempat dan kelima adalah 100%. Hasil Rata-rata tingkat keberhasilan dari semua hasil analisa adalah 90,04% yang diukur dari rata-rata perbandingan jumlah data percobaan berhasil dan jumlah data pengamatan untuk tiap-tiap citra.
Integrating the Concept of Plane Figure and Baduy Local Wisdom as a Media Alternative of Mathematics Learning In Elementary Schools
Authors: Arisetyawan Andika , Taher Tarmizi , Fauzi Irfan 
Published: June 2022

This study aims to develop a learning media product that contains the local wisdom of the Baduy tribe. The method used in this research is an ethnographic study to collect data about the Baduy tribe buildings that contain geometric elements. After the data was collected, the researcher used the instructional design research method in the form of the ADDIE model with the aim of making learning media by integrating the local wisdom of the Baduy Tribe in learning geometry based on previous ethnographic studies. The subjects in this study were the Baduy people, teachers, and grade 4 students of one of the elementary schools in Serang City. The results of this study indicate that learning geometry by integrating the local wisdom of the Baduy tribe is very effective in the learning process, so that the learning media product in the form of geomatics cards that are made is ready to be used and implemented in the concept of the plane figure in elementary schools. This research is expected to contribute to education, especially in creating effective learning by integrating culture in mathematics learning in elementary schools.Penelitian ini bertujuan untuk mengembangkan sebuah produk media pembelajaran yang memuat kearifan lokal suku Baduy. Metode yang digunakan dalam penelitian ini adalah studi etnografi untuk mengumpulkan data-data tentang bangunan suku Baduy yang memuat unsur geometri. Setelah data terkumpul, peneliti menggunakan metode instructional design research berupa model ADDIE dengan tujuan untuk membuat media pembelajaran dengan mengintegrasikan kearifan local Suku Baduy pada pembelajaran geometri berdasarkan kajian etnografi sebelumnya. Subjek dalam penelitian ini adalah masyarakat Suku Baduy, guru dan siswa kelas 4 salah satu sekolah dasar di Kota Serang. Hasil penelitian ini menunjukkan bahwa pembelajaran geometri dengan mengintegrasikan kearifan local Suku Baduy sangat efektif diterapkan dalam proses pembelajaran, sehingga produk media pembelajaran berupa kartu geomatika yang dibuat telah siap digunakan dan diimplementasikan padaÂ konsep bangun datar di sekolah dasar. Penelitian ini diharapkan dapat memberikan kontribusi dalam dunia pendidikan khususnya dalam menciptakan pembelajaran yang efektif dengan mengintegrasikan budaya pada pembelajaran matematika di sekolah dasar.
No need of glucocorticoid dose adjustment in patients with adrenal insufficiency before COVID-19 vaccine
Authors: Pilli Tania , Dalmiglio Cristina , Dalmazio Gilda , Sagnella Alfonso , Forleo Raffaella , Brilli Lucia , Maino Fabio , Ciuoli Cristina , Castagna Maria Grazia 
Published: June 2022

Abstract

Objective
Coronavirus disease-2019 (COVID-19) causes acute respiratory distress syndrome. Patients with adrenal insufficiency (AI) may develop severe complications due to this infection and should undergo COVID-19 vaccination; however, there is no consensus about the management of their replacement therapy. The aim of our study was to evaluate the tolerability and need for glucocorticoid dose adjustment related to COVID-19 mRNA vaccines in a cohort of patients with AI.

Design and methods
We prospectively administered to 88 patients (51 M/37 F; mean age: 62.3 ± 16 years), with AI (28 primary and 60 secondary AI), a questionnaire about the occurrence, severity and duration of the side effects and the need for glucocorticoid dose adjustment within 1 week after the first and the second dose of COVID-19 mRNA vaccines (Pfizer–BioNTech and Moderna).

Results
Side effects of mild to moderate severity occurred in about 70% of patients after both vaccine doses. The most common adverse events were pain at the injection site, fatigue, fever and flu-like symptoms. The occurrence and severity of the side effects were not correlated to gender, type of AI and mRNA vaccine, but their total number was higher after the second vaccine dose. Doubling the oral glucocorticoid dose was needed in up to 8% of patients, especially after the second vaccine dose, but no parenteral administration was required.

Conclusions
COVID-19 mRNA vaccines were well tolerated in patients with AI. Side effects were similar to those observed in the general population, and increasing glucocorticoid replacement therapy before vaccine administration was not needed.