bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of fuel cell and electric public for transport busses
Authors: Cărăuşan H. , Varga B. O. , Moldovanu D. , Sirca A. A. 
Published: October 2022

Abstract
Current public transport systems have been in desperate need of modernization in the past decade. The pressing issue of climate change, alongside the ever-increasing strictness of emission standards, have guided public transport operators towards the use of alternative propulsion vehicles. The most popular option to conventional powered public transport vehicles have been BEBs (Battery Electric Busses). However, in the past years, FCEBs (Fuel Cell Electric Busses) have gained massive ground in this sector. The following paper aims to shed a light on the advantages and disadvantages of both technologies, in order to determine whether or not FCEBs represent a viable solution for the future.
The Predictive Validity of the Danish Psychosocial Work Environment Questionnaire With Regard to Onset of Depressive Disorders and Long-Term Sickness Absence
Authors: Clausen Thomas , Christensen Karl Bang , Sørensen Jeppe Karl , Bjorner Jakob B , Madsen Ida E H , Borg Vilhelm , Rugulies Reiner 
Published: October 2022

AbstractObjectivesTo investigate the predictive validity of 32 measures of the Danish Psychosocial Work Environment Questionnaire (DPQ) against two criteria variables: onset of depressive disorders and long-term sickness absence (LTSA).MethodsThe DPQ was sent to 8958 employed individuals in 14 job groups of which 4340 responded (response rate: 48.4%). Depressive disorders were measured by self-report with a 6-month follow-up. LTSA was measured with a 1-year follow-up in a national register. We analyzed onset of depressive disorders at follow-up using logistic regression models, adjusted for age, sex, and job group, while excluding respondents with depressive disorders at baseline. We analyzed onset of LTSA with Cox regression models, adjusted for age, sex, and job group, while excluding respondents with previous LTSA.ResultsThe general pattern of the results followed our hypotheses as high job demands, poorly organized working conditions, poor relations to colleagues and superiors, and negative reactions to the work situation predicted onset of depressive disorders at follow-up and onset of LTSA during follow-up. Analyzing onset of depressive disorders and onset of LTSA, we found risk estimates that deviated from unity in most of the investigated associations. Overall, we found higher risk estimates when analyzing onset of depressive disorders compared with onset of LTSA.ConclusionsThe analyses provide support for the predictive validity of most DPQ-measures. Results suggest that the DPQ constitutes a useful tool for identifying risk factors for depression and LTSA in the psychosocial work environment.
Preventing Soft Tissue Complications in Secondary Aesthetic Breast Surgery Using Indocyanin Green Angiography
Authors: Salgarello Marzia , Pino Valentina , Pagliara Domenico Maria , Visconti Giuseppe 
Published: October 2022

Abstract

Background
Secondary cosmetic breast surgery after primary augmentation with implant can be associated with an increased risk of adverse events. Partial/complete nipple-areola complex necrosis is particularly feared. In this preliminary study, the authors propose the utilization of indocyanine green (ICG) angiography to assess the blood supply of breast tissue after implant removal.

Objectives
The main objective was to prevent skin and gland necrosis in revision breast surgery.

Methods
The authors performed a retrospective comparative analysis of 33 patients who underwent secondary breast surgery between 2018 and 2021 by a single surgeon (M.S.). Breast tissue perfusion was assessed in 16 patients by intraoperative ICG angiography at the end of implant removal and possible capsulectomy. Non-stained/non-fluorescent areas were judged to be low perfusion areas and were excised with short scar mastopexy.

Results
In the ICG angiography group, 7 patients (44%) showed an area of poor perfusion along the inferior pole; all of these patients underwent subglandular breast augmentation. Resection of the poor perfusion areas allowed an uneventful postoperative course. In the non­­- ICG angiography group (17 patients), 5 patients experienced vertical-scar dehiscence/necrosis. We found a statistically significant association between the non-ICG angiography group and vertical scar dehiscence/necrosis, and also between vertical scar dehiscence/necrosis and subglandular implant placement (P = 0.04).

Conclusions
Safer secondary surgery can be offered to patients undergoing secondary aesthetic breast procedures, especially when the first augmentation surgery is unknown—for example, implant plane, type of pedicle employed, if the implant is large and subglandular, and if capsulectomy is performed.

Level of Evidence: 4
Prospective Study of Clinical Outcomes From a Breast Implant Assessment Service
Authors: Masoumi Elnaz , Seow Christina , Deva Anika Preeti , Cuss Amanda , Chow Oliver , Davies Matthew , Lajevardi Sepehr , Connell Tony , Magnusson Mark , Beath Kenneth , Isacson Daniel , Deva Anand K 
Published: October 2022

Abstract

Background
Breast augmentation remains the commonest cosmetic surgical procedure worldwide, in spite of recent regulatory action.

Objectives
The aim of this study was to evaluate women with breast implants attending a breast implant assessment clinic and to capture clinical and implant data in women presenting to the service.

Methods
Patients were enrolled prospectively between January 2018 and December 2021. Clinical, implant, and practitioner data were recorded. Patients reported satisfaction on size, shape, and overall outcome as well as the presence or pain. Radiological evaluation, where indicated, was performed and data were included on these findings.

Results
A total of 603 patients were assessed. Their mean age was 42.7 years and mean age at implantation was 29.1 years. The most common complications were capsular contracture followed by pain, waterfall deformity, and double bubble, with rupture/contracture rates increasing after the 10-year mark. The risk of double bubble was significantly lower if patients were operated on by certified practitioners (odds ratio = 0.49, P = 0.011). There was almost universally poor awareness of the risks of breast implants in patients presenting for evaluation.

Conclusions
This study has shown benefit in a breast implant assessment clinic to gather information on adverse events and patient-reported outcomes following breast implant surgery. Having appropriately trained and certified practitioners perform cosmetic augmentation significantly lowers the risk of implant malposition and deformity. Any adverse event occurring within 5 years of initial surgery should be flagged as a mandatory reportable clinical indicator and trigger further investigation.

Level of Evidence: 2
MHADTI: predicting drug–target interactions via multiview heterogeneous information network embedding with hierarchical attention mechanisms
Authors: Tian Zhen , Peng Xiangyu , Fang Haichuan , Zhang Wenjie , Dai Qiguo , Ye Yangdong 
Published: October 2022

AbstractMotivationDiscovering the drug–target interactions (DTIs) is a crucial step in drug development such as the identification of drug side effects and drug repositioning. Since identifying DTIs by web-biological experiments is time-consuming and costly, many computational-based approaches have been proposed and have become an efficient manner to infer the potential interactions. Although extensive effort is invested to solve this task, the prediction accuracy still needs to be improved. More especially, heterogeneous network-based approaches do not fully consider the complex structure and rich semantic information in these heterogeneous networks. Therefore, it is still a challenge to predict DTIs efficiently.ResultsIn this study, we develop a novel method via Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interactions (MHADTI). Firstly, MHADTI constructs different similarity networks for drugs and targets by utilizing their multisource information. Combined with the known DTI network, three drug–target heterogeneous information networks (HINs) with different views are established. Secondly, MHADTI learns embeddings of drugs and targets from multiview HINs with hierarchical attention mechanisms, which include the node-level, semantic-level and graph-level attentions. Lastly, MHADTI employs the multilayer perceptron to predict DTIs with the learned deep feature representations. The hierarchical attention mechanisms could fully consider the importance of nodes, meta-paths and graphs in learning the feature representations of drugs and targets, which makes their embeddings more comprehensively. Extensive experimental results demonstrate that MHADTI performs better than other SOTA prediction models. Moreover, analysis of prediction results for some interested drugs and targets further indicates that MHADTI has advantages in discovering DTIs.Availability and implementationhttps://github.com/pxystudy/MHADTI
AIscEA: unsupervised integration of single-cell gene expression and chromatin accessibility via their biological consistency
Authors: Jafari Elham , Johnson Travis , Wang Yue , Liu Yunlong , Huang Kun , Wang Yijie 
Published: October 2022

Abstract

Motivation
The integrative analysis of single-cell gene expression and chromatin accessibility measurements is essential for revealing gene regulation, but it is one of the key challenges in computational biology. Gene expression and chromatin accessibility are measurements from different modalities, and no common features can be directly used to guide integration. Current state-of-the-art methods lack practical solutions for finding heterogeneous clusters. However, previous methods might not generate reliable results when cluster heterogeneity exists. More importantly, current methods lack an effective way to select hyper-parameters under an unsupervised setting. Therefore, applying computational methods to integrate single-cell gene expression and chromatin accessibility measurements remains difficult.

Results
We introduce AIscEA—Alignment-based Integration of single-cell gene Expression and chromatin Accessibility—a computational method that integrates single-cell gene expression and chromatin accessibility measurements using their biological consistency. AIscEA first defines a ranked similarity score to quantify the biological consistency between cell clusters across measurements. AIscEA then uses the ranked similarity score and a novel permutation test to identify cluster alignment across measurements. AIscEA further utilizes graph alignment for the aligned cell clusters to align the cells across measurements. We compared AIscEA with the competing methods on several benchmark datasets and demonstrated that AIscEA is highly robust to the choice of hyper-parameters and can better handle the cluster heterogeneity problem. Furthermore, AIscEA significantly outperforms the state-of-the-art methods when integrating real-world SNARE-seq and scMultiome-seq datasets in terms of integration accuracy.

Availability and implementation
AIscEA is available at https://figshare.com/articles/software/AIscEA_zip/21291135 on FigShare as well as {https://github.com/elhaam/AIscEA} onGitHub.

Supplementary information
Supplementary data are available at Bioinformatics online.
The Inflammation Biomarker GlycA Reflects Plasma N-Glycan Branching
Authors: Noel Maxence , Chasman Daniel I , Mora Samia , Otvos James D , Palmer Christopher D , Parsons Patrick J , Smoller Jordan W , Cummings Richard D , Mealer Robert G 
Published: October 2022

Abstract

Background
GlycA is a nuclear magnetic resonance (NMR) signal in plasma that correlates with inflammation and cardiovascular outcomes in large data sets. The signal is thought to originate from N-acetylglucosamine (GlcNAc) residues of branched plasma N-glycans, though direct experimental evidence is limited. Trace element concentrations affect plasma glycosylation patterns and may thereby also influence GlycA.

Methods
NMR GlycA signal was measured in plasma samples from 87 individuals and correlated with MALDI-MS N-glycomics and trace element analysis. We further evaluated the genetic association with GlycA at rs13107325, a single nucleotide polymorphism resulting in a missense variant within SLC39A8, a manganese transporter that influences N-glycan branching, both in our samples and existing genome-wide association studies data from 22 835 participants in the Women’s Health Study (WHS).

Results
GlycA signal was correlated with both N-glycan branching (r2 ranging from 0.125–0.265; all P &lt; 0.001) and copper concentration (r2 = 0.348, P &lt; 0.0001). In addition, GlycA levels were associated with rs13107325 genotype in the WHS (β [standard error of the mean] = −4.66 [1.2674], P = 0.0002).

Conclusions
These results provide the first direct experimental evidence linking the GlycA NMR signal to N-glycan branching commonly associated with acute phase reactive proteins involved in inflammation.
Pygmalion and Medusa as Cixous’ writing women inInSEXts: ‘I Write Woman’
Authors: Swain Natalie J 
Published: October 2022

AbstractSet in nineteenth century Europe, InSEXts tells the story of Lady Bertram and Mariah, two women in a romantic relationship who can transform into insects in order to defend their nascent family. In the second arc of the series, The Necropolis, Lady Bertram, and Mariah are joined by Phoebe (a Black, transgender artist) whose friends are being transformed into art by members of the patriarchal art community, who value women only as silent and beautiful Muses. Allying with ‘Medusa’, a misidentified Javanese goddess who has been forcibly brought to Europe, Lady Bertram and Mariah thus enter a narrative replete with Greek and Roman mythology. In this paper, the author sets out to demonstrate that, through the receptions of Pygmalion and Medusa, InSEXts: The Necropolis effectively reflects Cixous’ ‘Laugh of the Medusa’, replicating the empowerment of female creativity which Cixous suggests. By mirroring these Ovidian intertexts and becoming ‘writing women’ themselves, comics creators Bennett and Kristantina allow their own characters to re-write and subvert traditional narratives, to tell their own stories that represent elements of Ovidian narrative to respond to and embody the kind of female creativity advocated by Cixous.
The Humed Serpent: Lucian, miracles, enlightenment, and empire
Authors: Devecka Martin 
Published: October 2022

AbstractIn his essay ‘Of Miracles’, published separately and as the final chapter of his Enquiry Concerning Human Understanding, David Hume enlists Lucian’s Alexander, or the False Prophet as evidence for his claim that miracle narratives first take root among gullible rural populations before spreading to cultured city-dwelling elites. This essay reads Lucian’s Alexander and On the Death of Peregrinus against the Humean grain to suggest that miracle stories emerge as a consequence of the forms of commerce and circulation enabled by empires. In light of this, I recharacterize Hume’s geography of gullibility as an aspirational but unsustainable ideal engendered by the emergence of an eighteenth-century ‘Republic of Letters’.
Catch Effectiveness Revealed by Site-Related Differences in Capture–Mark–Recapture Methods: A Butterfly Metapopulation Study
Authors: Adamski Paweł 
Published: October 2022

AbstractUnderstanding metapopulation structures is very important in the context of ecological studies and conservation. Crucial in this respect are the abundances of both the whole metapopulation and its constituent subpopulations. In recent decades, capture–mark–recapture studies have been considered the most reliable means of calculating such abundances. In butterfly studies, individual insects are usually caught with an entomological net. But the effectiveness of this method can vary for a number of reasons: differences between fieldworkers, in time, between sites etc. This article analyses catch effectiveness data with respect to two subpopulations of the Apollo butterfly (Parnassius apollo) metapopulation in the Pieniny National Park (Polish Carpathians). The results show that this parameter varied significantly between sites, probably because of differences in microrelief and plant cover. In addition, a method is proposed that will include information on catch effectiveness for estimating the sizes of particular subpopulations and will help to elucidate the structure of the entire metapopulation.
A case of covered stent failure in sealing up a coronary perforation potentially related to intravascular lithotripsy treatment: insights from optical coherence tomography
Authors: Doost Ata , Mabote Thato , Clugston Richard , Ihdayhid Abdul Rahman 
Published: October 2022

Abstract

Background
Intravascular lithotripsy (IVL) is a new modality in treatment of calcified coronary lesions which improves procedural outcomes. Coronary perforation is an extremely uncommon but potentially catastrophic complication of percutaneous coronary intervention (PCI) and IVL therapy.

Case summary
We report a case of an elective PCI to a calcified left anterior descending (LAD) and diagonal bifurcation lesion in a 65-year-old man. LAD was treated with two stents. Despite high pressure non-compliant balloon inflation, a focal area of under-expansion remained. IVL successfully treated the under-expansion but was complicated with a large coronary perforation. The perforation was successfully sealed with a PK-PAPYRUS covered stent sacrificing the diagonal branch. Patient remained stable until 3 hours later when he developed tamponade requiring urgent pericardial drainage. Repeat angiography demonstrated recanalization of the diagonal branch and ongoing contrast extravasation along its course. Optical coherence tomography intracoronary imaging was used to delineate the mechanism of ongoing bleeding. This demonstrated an interrupted elastic membrane of the covered stent, potentially caused by underlying fractured calcium. Therefore, a second overlying PAPYRUS stent was deployed which satisfactorily sealed the perforation.

Discussion
IVL is an emerging less invasive treatment for calcified coronary stenosis but could be associated with drastic complications. This case highlights the importance of awareness of IVL-related coronary perforation and the potential limitation of new generation thinner-wall covered stents. Intracoronary imaging plays an important role in identifying mechanisms of stent failure, tailoring treatment, and optimizing outcomes.
Total anomalous pulmonary venous return with mixed drainage and double connection: a rare case report not previously described
Authors: Rocamora Salort Sandra , Ruiz González Eladio , Cano Sánchez Ana , Fernández Tudela Belén 
Published: October 2022

Abstract

Background
Total anomalous pulmonary venous return is a rare cyanotic congenital heart disease in which pulmonary veins connect to the systemic veins, right atrium, or coronary sinus. Given its variability, it is essential to define the pathway and drainage site.

Case summary
We describe a 3-day-old patient with total anomalous pulmonary venous return, in which the four pulmonary veins drained into a common vertical vein that had a double connection at the cardiac (coronary sinus) and infracardiac (portal vein) levels. The echocardiographic diagnosis was confirmed by computed tomography scan. At 1.5 months, she underwent surgery by anastomosis of the venous collector with the left atrium, unroof of the coronary sinus, and clousure of its communication with right atrium. The vertical vein was ligated. There were no complications after 1 year of follow-up.

Discussion
This is an unusual anatomy that has not been described in the literature. In this article, we discuss the embryological origin. Furthermore, we highlight the importance of an accurate diagnosis of the venous pathway and its impact on surgical planning and patient prognosis.
Management of patients with left main stem stenosis in Iceland 2010–2020: PCI or CABG?
Authors: Reynisdottir H O , Kristjansdottir M K , Mogensen B A , Gudbjartsson T , Andersen K A , Sigurdsson M I , Gudmundsdottir I J 
Published: October 2022

Abstract

Introduction
Coronary artery bypass surgery (CABG) has been standard treatment for patients with left main coronary artery disease (LMCAD) but percutaneous coronary intervention (PCI) is a good alternative in selected patients.
Our purpose was to evaluate the prevalence of LMCAD in Iceland, the impact of background factors on treatment choices, and treatment changes in recent years with respect to current guidelines.

Methods
This retrospective, population-based study analyzed data from the SCAAR-SWEDEHEART database. Patients with significant LMCAD on coronary angiography in Iceland 2010–2020, without previous history of CABG or contraindication for surgery were enrolled. Survival analysis was estimated with Kaplan-Meier and COX regression analysis for investigating the association between survival time and predictor variables.

Findings
Of 702 patients with LMCAD, 195 were treated with PCI, 460 with CABG and 47 with medical treatment only. The widest age range was in the PCI group and the mean age was highest in the medical therapy only group (p&lt;0.001). Patients with LMCAD and either three vessel disease or heart valve disease were most often treated with CABG (76.1% and 84.4%, p&lt;0.001).The majority of patients with LMCAD only were treated with PCI, as were patients with STEMI or cardiogenic shock (67.1% and 70.0%, p&lt;0.001). The proportion of patients treated with PCI increased from 19.8% in 2010–2015 to 42.7% in 2016–2020. There was no significant difference in survival between PCI and CABG (p=0.41).

Conclusions
In patients with LMCAD the main factors that affect treatment choice are age, anatomical complexity and acuteness. Treatment choice appears to be in keeping with current guidelines. There is no significant difference in long term survival between PCI and CABG groups but the groups are different. There has been a significant increase in patients treated with PCI in recent years.

Funding Acknowledgement
Type of funding sources: None.