bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and safety of massage for chronic pain in patients with knee osteoarthritis
Authors: Xu Jianghan , Wu Boyi , Xie Shengji , Wu Guanghui , Zhang Heng , Fu Yangyang , Guo Guangxin 
Published: January 2022

Abstract

Background:
Chronic pain (CP) is a common and debilitating symptom in patients with knee osteoarthritis (KOA). Massage has been supported as a non-pharmacological intervention for the individual symptom relief of CP. However, relevant evidence of using massage for CP in patients with KOA has been lacking.

Methods:
A systematic search will be performed in the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage for CP of KOA: China National Knowledge Infrastructure (CNKI), Wan Fang, PubMed, EMBASE, PsycINFO, and the Cochrane Library databases from their inception to December 2021. The entire process will include study selection, data extraction, risk of bias assessment and meta-analysis.

Results:
This proposed study will evaluate the effectiveness and safety of massage for CP in patients with KOA. Changes in pain relief and adverse effect will be included in our outcomes.

Conclusions:
This systematic review will provide evidence for assessing the credibility of massage for CP in patients with KOA.

Dissemination and ethics:
The results of this review will be disseminated through peer-reviewed publication. This review does not require ethical approval because all of the data used in this systematic review and meta-analysis have already been published. Furthermore, all of these data will be analyzed anonymously during the review process.
Congenital nephrogenic diabetes insipidus presenting as osmotic demyelination syndrome in infancy
Authors: Kobayashi Satoru , Mizuno Nana , Yokoi Kyoko , Mori Takayasu , Sohara Eisei , Uchida Shinichi 
Published: January 2022

Abstract

Rationale:
Almost 90% of congenital nephrogenic diabetes insipidus (NDI) cases are caused by mutations in the arginine vasopressin receptor 2 gene, which has X-linked recessive inheritance. Although NDI is commonly diagnosed in early infancy based on its characteristic findings, clinical diagnosis can be delayed when no other family members have been diagnosed with NDI because several findings of NDI are nonspecific.

Patient concerns:
A 3-month-old boy diagnosed with NDI presenting with osmotic demyelination syndrome (ODS) was admitted for poor weight gain after birth and poor feeding during the week prior to admission.

Diagnosis:
On admission, the initial blood examination showed hypernatremia (158 mmol/L), and treatment with intravenous fluids over the next 2 days further elevated the serum sodium level (171 mmol/L). After admission, polyuria was recognized, and polyuria in his grandmother and mother since childhood without a diagnosis of NDI was found. Magnetic resonance imaging showed multifocal, symmetrical lesions, including the lateral pons, on diffusion- and T2-weighted imaging, which led to a diagnosis of ODS.

Intervention:
The infusion was stopped, and the patient was fed milk diluted 2-fold with water.

Outcomes:
The serum sodium level gradually decreased to 148 mmol/L over the course of 1 week. Low-sodium milk was started at 4 months of age and maintained a serum sodium level of approximately 140 mmol/L, which was within the normal range. The developmental quotient was 94 at 4 years of age.

Lessons:
ODS is an encephalopathy resulting from extreme fluctuations in serum sodium concentration and plasma osmolality. ODS due to hypernatremia has been reported in several patients, although it usually occurs during rapid correction of hyponatremia. Consequences of the central nervous system are a critical complication of NDI that affects prognosis. These consequences can be avoided with treatment. Early blood examination or polyuria in the patient, mother, or another family member and hypernatremic dehydration with good urine output should lead to an early diagnosis and prevent central nervous system consequences.
Shoulder impingement: various risk factors for supraspinatus tendon tear
Authors: Ahmad Rani G. 
Published: January 2022

Abstract
A total of 680 cases of monolateral shoulder pain and functional impairment were included, and Chi-Squared tests was incorporated to test for possible associations.
No relation between impingement syndrome and potential risk factors was found, such as presence of down slopping (P = .083), presence of ossification acromiale (P
= .102), presence of calcific tendinitis (P
= .144), types of acromion (I [P = .600], II [P = .536], III [P = .633] and IV [P = .832]) and grade of acromioclavicular degenerative changes (mild [P = .077], moderate [P = .111], and severe [P = .700]). However, a significant relationship was uncovered between impingement syndrome and risk factors such as gender (X2 = 7.004, df = 1, P = .08) (where females were more prone), history of shoulder dislocation (X2 = 19.440, df = 1, P = .001), presence of supraspinatus tendon tear or tendinopathy (X2 = 69.344, df = 1, P = .001) and supraspinatus complete tear (X2 = 13.593, df = 1, P = .001). A significant relationship was found between the type of supraspinatus pathology and factors such as gender (female more prone) (X2 = 34.719, df = 3, P = .01), presence of down slopping (X2 = 57.765, df = 3, P = .01), history of shoulder dislocation (X2 = 148.880, df = 3, P = .001), type III of the acromion (X2 = 12.979, df = 3, P = .005), presence of acromioclavicular generative changes mild (X2 = 76.408, df = 3, P = .001) and moderate (X2 = 29.697, df = 3, P = .001), and acromiohumeral distance of ≤3 mm (X2 = 18.915, df = 3, P = .001), 3.1 to 6 mm (X2 = 13.212, df = 3, P = .004), and 9.1–12 mm (X2 = 15.066, df = 3, P = .002). Overall, the Magnetic Resonance Imaging results yielded high sensitivity for detecting full-thickness supraspinatus tears.
Considering the findings, this study may help radiologists understand the salient risk factors and identify which factors are mainly responsible for supraspinatus tendon tears and the respective grade of tear (articular partial, bursal partial, complete, or tendinopathy).
Bipolar clavicle fractures treatment using medial and lateral double plates
Authors: Xing Haiyang , Cao Changpeng , Chen Xinxiao , Gao Yang , Huang Guanning , Zhu Jiajing , Wang Gang 
Published: January 2022

Abstract

Rationale:
Clavicle fractures are common, accounting for 2.6 to 4% of all fractures, which typically result from direct injuries, including direct force on the shoulder after falling. However, bipolar clavicle fractures are rare, accounting for only 2.8% of all clavicle fractures, and their injury mechanism is speculated to evolve from two independent and continuous forces affecting the clavicle. Due to its low incidence, there is great controversy regarding the treatment of this fracture, as there is no relevant treatment standard or guideline to date.

Patient concerns:
In this case report, we describe a rare case of bipolar clavicle fracture in a 76-year-old man with multiple systemic fracture complications due to a traffic injury. He presented with limited shoulder function and movement upon arrival in the emergency room.

Diagnosis:
Bipolar clavicle fracture in the right shoulder (Robinson type 1B2, Robinson type 3B2)

Interventions:
We performed trans-sternoclavicular locking plate and lateral clavicular hook plate treatments and instructed patients to perform reasonable postoperative functional exercises.

Outcomes:
Three months postoperatively, the pain was almost completely relieved with a DASH score of 40.0. Furthermore, radiographic examination of the clavicle showed satisfactory fracture healing. The patient had no further demands for shoulder function and no irritative symptoms of internal fixation and refused to undergo a second operation. The patient had a satisfactory prognosis after the treatment.

Lessons:
The treatment of bipolar clavicle fractures remains controversial. This study provides evidence of a feasible method to treat bipolar clavicle fractures: trans-sternoclavicular locking plate and lateral clavicular hook plate treatment.
The efficacy of parenteral nutrition (PN) and enteral nutrition (EN) supports in cirrhosis
Authors: Yu Bin , Wang Jiting 
Published: January 2022

Abstract

Importance:
Multiple nutritional therapies are currently available for patients with liver cirrhosis, yet many interventions have not been compared head-to-head within randomized clinical trials.

Objective:
To evaluate the improvement of nutritional indicators and liver function indexes of liver cirrhosis treated with different nutrition intervention.

Data source:
We searched PubMed, Embase. com and Cochrane Library database from construction to April 3, 2020. After eliminating the duplicated or overlapping reports, 6 studies were included. We performed a Bayesian network meta-analysis by Stata 12.0 and GeMTC 0.14.3 in order to compare different nutritional interventions with consistency model.

Study selection:
Randomized clinical trials comparing 2 or more therapies in patients with cirrhosis were evaluated. Six randomized clinical trials met the selection criteria.

Data extraction and synthesis:
Two investigators independently reviewed the full manuscripts of eligible studies and extracted information into an electronic database: patients’ characteristics study design, interventions, the number of events of interest in each group.

Main outcomes and measures:
Body mass index, Child-Pugh score, model for end-stage liver disease score, total bilirubin, alanine transaminase, aspartate transaminase, total protein, Triceps skinfold, Midarm Muscle Circumference, Fischer ratio, overall survival.

Results:
There are 6 studies enrolling a total of 1148 patients who received different nutrition supports including parenteral nutrition (PN), enteral nutrition (EN), EN (without branched-chain amino acids), EN + intestinal probiotics, PN + EN, late evening snacks (LES), EN + LES, noLES. The direct comparisons showed that the effect of EN was better than EN (without branched-chain amino acids); EN + intestinal probiotics was better than EN and PN; PN + EN was better than them alone; EN + LES was better than LES and EN; LES was better than noLES. Although the difference of indirect comparisons between the included regimens was not statistically significant, the results showed that EN + intestinal probiotics appeared to be superior to PN + EN. While LES and EN + LES seemed to rank behind them and the difference between them was extremely small.

Conclusion and relevance:
Available evidence suggests that EN + intestinal probiotics appear to be the most effective strategy for patients with cirrhosis compared with other interventions.
Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean
Authors: Yamamoto-Furusho Jesús K. , Parra-Holguín Norma N. , Juliao-Baños Fabián , Puentes Fabián , López Rocio , Bosques-Padilla Francisco , Torres Esther A. , Nieves-Jimenéz Humberto , Veitia-Velásquez Guillermo R. , Jara-Alba Maria L. , Bautista Sócrates , Piñol-Jimenez Felipe N. , Salgado-Rosado Pablo , Villa-Ovalles Keyla C. , Abreu-Martinez Yudelka A. , Borges Zunilda , Davila-Bedoya Santiago , Otoya-Moreno Guillermo , Iadé-Vergara Beatriz 
Published: January 2022

Abstract
The aim of the present study was to describe the epidemiological and clinical characteristics of inflammatory bowel disease (IBD), including medical and surgical treatments, in several countries in Latin America and the Caribbean.
IBD is recognized as a global health problem because its incidence and prevalence have increased significantly over the last few years.
This multicenter retrospective cohort study included 4714 patients with IBD diagnosed from 9 countries in Latin America and the Caribbean: Colombia, Cuba, Dominican Republic, Ecuador, Mexico, Peru, Puerto Rico, Uruguay, and Venezuela.
Crohn disease (CD) was more frequent in Puerto Rico (71.9%), the Dominican Republic (61.0%), and Peru (53.1%). Ulcerative colitis was more frequent in Colombia (78.6%), Venezuela (78.2%), Mexico (75.5%), Cuba (69.9%), Ecuador (64.1%), and Uruguay (60.9%). The following clinical characteristics were more frequent in the Caribbean: penetrating behavior in CD, steroid dependence, steroid resistance, intolerance to thiopurines, extraintestinal manifestations, surgeries, hospitalizations due to IBD, and family history of IBD. The factors associated with the use of biological therapy were pancolitis in ulcerative colitis, penetrating behavior in CD, steroid resistance and dependence, presence of extraintestinal manifestations, and the need for surgery.
This study from Latin America and the Caribbean demonstrated the different epidemiological and clinical characteristics of IBD.
Effectiveness and safety of acupuncture for treating trigeminal neuralgia associated anxiety and depression
Authors: Luo Ning , Li Rongrong , Wang Yiyi , Xia Yunfan , Sun Jing , Zhao Linfang , Sun Chao , Sun Jiemin , Fang Jianqiao 
Published: January 2022

Abstract

Background:
Patients with trigeminal neuralgia (TN) often develop a terrible fear of triggering pain, which may lead to anxiety and depression, exerting a negative effect on their quality of life. This protocol is carried out to comprehensively explore the effectiveness and safety of acupuncture for treating anxiety and depression induced by TN.

Methods:
Randomized control trials involving acupuncture for treating patients with anxiety and depression caused by TN will be searched in eight electric databases, including PubMed, Web of Science, EMBASE, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database and Technology Periodical Database (VIP). In addition, studies that were reported in Chinese or English will be considered. Studies selection, data extraction and risk of bias assessment of the included studies will be conducted independently by two reviewers. Quality of the included studies will be performed according to the Cochrane Risk of Bias tool. Meanwhile, the level of evidence for results will be assessed by using the Grading of Recommendations Assessment, Development, and Evaluation method. The primary outcomes will be the Hamilton Anxiety/Depression Scale or Zung Self-Rating Anxiety/Depression Scale, secondary outcomes will be the visual analog score, numerical rating score, SF-36, and adverse events. All analyses will be conducted by using the RevMan software V5.3.

Results:
A high-quality synthesis of current evidence of acupuncture for TN patients associated with anxiety and depression will be provided in this study.

Conclusion:
This systematic review will offer comprehensive evidence of acupuncture on specific outcomes induced by TN and TN-related anxiety and depression.

Trial registration:
PROSPERO registration number: CRD42020219775.
Enhancing parental knowledge of childhood and adolescence safety
Authors: Temsah Mohamad-Hani , Aljamaan Fadi , Alhaboob Ali , Almosned Badr , Alsebail Raghad , Temsah Reem , Senjab Abdulrahman , Alarfaj Abdulrahman , Aljudi Talal , Jamal Amr , Habash Alia , Alsohime Fahad , Almazyad Mohammed , Alabdulhafid Majed , Hasan Gamal , Assiri Raghad Asaad , Alqahtani Wa’ad Massoud Almunassir , Alherbish Adi , Alhasan Khalid , Al-Eyadhy Ayman 
Published: January 2022

AbstractBackground:Safeguarding children and adolescents from unintentional injuries is a significant concern for parents and caregivers. With them staying more at home during the coronavirus disease 2019 pandemic, more educational tools and valid educational programs are warranted to improve parental knowledge and awareness about childhood and adolescences’ safety. This study aims to explore the effectiveness of childhood and adolescence safety campaigns on parents’ knowledge and attitude toward preventable injuries.Methods:This was a pre–post experimental study, in which the predesigned assessments were used as an evaluation tool before and after attending a childhood and adolescence safety campaign. The pre–post assessment question included questions to evaluate the socio-demographic status, followed by knowledge questions in line with the current childhood and adolescence safety campaign. The outcomes of interest were assessed before and after attending the campaign's stations.Results:Three hundred eight parents volunteered to participate in this study. Their knowledge score improved from 36.2 [standard deviation (SD) 17.7] to 79.3 (SD 15.6) after attending the Campaign (t value = 34.6,P < .001). Both, perceptions on the preventability of accidents and the parents’ perceived usefulness of educational campaigns showed improvements, with (t value = 6.3,P < .001) and (t value = 3.097,P < .001), respectively.Conclusion:The educational childhood and adolescence safety campaign for caregivers in Saudi Arabia resulted in a significant increase in the overall knowledge and attitudes toward childhood and adolescence's safety. As children and adolescents are currently staying at home more, additional educational tools and programs are warranted to promote safe practices among parents and caregivers.
Relationship Between Body Temperature and Heart Rate in Children With No Other Apparent Cause of Tachycardia
Authors: Matsumura Osamu , Morikawa Yoshihiko , Kaneko Tetsuji , Sakakibara Hiroshi , Hagiwara Yusuke 
Published: January 2022

Objective
The aim of the study was to investigate the normal heart rate range for each body temperature in patients visiting the emergency department (ED) with no other, apparent, coexisting factors causing tachycardia.

Methods
This was an observational study conducted in the ED at a single children's hospital between April 1, 2014, and March 31, 2017. Data on all visits were extracted from the electronic triage system and were excluded if they indicated the presence of factors other than body temperature potentially increasing the heart rate. We created age-dependent heart rate percentile curves for body temperature in 6 age categories: 0 to younger than 3 months, 3 to younger than 12 months, 1 to younger than 2 years, 2 to younger than 5 years, 5 to younger than 10 years, and 10 years or older. The curves were created for the body temperatures of 36.0°C to 38.0°C for the 0 to younger than 3 months age group and for body temperatures of 36.0°C to 40.5°C for the other age groups.

Results
Of the 113,242 patients included, 61,321 were analyzed. The percentile curves across all age groups were similar despite differences in the baseline heart rate. Heart rate increase was steepest between 37.0°C and 38.0°C at a rate of approximately 20 beats per minute per degree Celsius for all groups. Compared with previous studies in the outpatient setting, including the ED, heart rate was lower in younger patients and was similar among older patients.

Conclusions
We created new, age-dependent heart rate percentile curves for body temperature for use in the ED setting. In outpatients, the effect of coexisting factors affecting heart rate, such as crying, may be higher among younger patients.
Measurable Residual Disease Assessment as a Surrogate Marker in New Drug Development in Acute Myeloid Leukemia
Authors: Gui Gege , Hourigan Christopher S. 
Published: January 2022

Abstract
Response criteria for patients treated for acute myeloid leukemia (AML) based on cytomorphology are inadequate. Many patients achieving a complete remission by such criteria will later relapse. Patients with AML in such remissions who test negative using higher sensitivity measures of residual disease burden (measurable residual disease [MRD]) have on average lower relapse rates and better survival than those testing positive. This association has raised the possibility that these technological advances in measurement of tumor burden could be used to optimize the drug development and regulatory approval processes in AML. The heterogeneous genetic etiology, diverse immunophenotypic profiles, related precursor states and polyclonal architecture however combine to make the development of standardized and validated MRD assessments for AML challenging. Current and future methods to measure residual disease in AML, performance characteristics of testing currently in use, and potential uses for optimized AML MRD tests including as a surrogate endpoint are discussed.
Checkpoint Inhibitors and Other Immune-Based Therapies in Acute Myeloid Leukemia
Authors: Haddad Fadi , Zeidan Amer M. , Daver Naval 
Published: January 2022

Abstract
Immune checkpoint inhibitors have been investigated in acute myeloid leukemia (AML) with an intent to harness the immune microenvironment components to generate an immune response against leukemia. Anti–cytotoxic T-lymphocyte–associated antigen 4 and anti–programmed cell death 1/programmed cell death ligand 1 antibodies have been evaluated in combination with low-intensity therapy and cytotoxic chemotherapy, both in the pretransplant and posttransplant settings. Although the objective response rates with programmed cell death 1– and programmed cell death ligand 1–based therapies have been relatively low, durable stable disease and hematologic improvement were noted in a subset of patients, important endpoints in patients with limited therapeutic options. Novel AML and myelodysplastic syndrome–specific checkpoints such as TIM3 antibodies in combination with azacitidine are showing encouraging efficacy, especially durability of response, in ongoing studies. Anti-CD47/SIRPα therapy in combination with azacitidine has shown encouraging efficacy and safety in frontline AML, especially in TP53-mutated AML, a population of significant unmet need. Other T cell–based immune therapies are under investigation. T-cell and natural killer cell bispecific and trispecific engagers have shown modest activity in patients with relapsed and/or refractory AML albeit with frequent cytokine release syndrome. Chimeric antigen receptor T-cell therapy showed immense success in many lymphoid malignancies and is being evaluated in AML. Future trials should be designed to select patients based on markers of response and tailor therapies according to predictive biomarkers.
Correlation Analysis of Lower-Limb Muscle Function With Clinical Status, Balance Tests, and Quality of Life in People With Parkinson Disease
Authors: Sá Rafael de Almeida , Ferreira Arthur de Sá , Lemos Thiago , de Oliveira Laura Alice Santos 
Published: January 2022

Aim:
To investigate the correlation of lower-limb muscle function with clinical status, balance, and quality of life in individuals with Parkinson disease (PD).

Methods:
Twenty-five participants were included. Outcome measures were assessed through scales and questionnaires. Quadriceps muscle function was assessed through a maximal isometric voluntary contraction. Spearman's correlation coefficient (ρ) analysis was performed.

Results:
Quadriceps peak force was negatively correlated with scores of the Unified Parkinson's Disease Rating Scale (UPDRS) part III (ρ= 0.610) but positively correlated with scores of the Mini-BESTest (ρ= 0.484) and the Timed Up and Go test (ρ= 0.528). The rate of force development was negatively correlated with scores of the UPDRS II (ρ=−0.437) and III (ρ=−0.577). Force variability was positively correlated with the quality of life (Parkinson's Disease Questionnaire 39; ρ= 0.455).

Conclusion:
Better quadriceps muscle function is associated with better clinical status, balance, and quality of life in people with PD.