bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy
Authors: Avdeeva A. S. , Rybakova V. V. , Alekseeva O. G. , Nasonov E. L. 
Published: September 2022

Objective: to evaluate the role of monitoring the level of matrix metalloproteinase 3 (MMP-3) in patients with rheumatoid arthritis (RA) during anti-B-cell therapy.Material and methods. The study included 54 patients with a reliable diagnosis of RA. Depending on the therapy, all patients were divided into two groups: 34 patients received the original RTM (group 1) and 20 patients – biosimilar (group 2) in a total dose of 1200 mg according to the standard scheme. The concentration of MMP-3 in serum was measured by enzyme immunoassay using a kit of reagents from Invitrogen (USA).Results. The level of MMP-3 in patients with RA was significantly higher than in healthy donors, its median was 42.9 [10.0; 110.7] and 7.8 [5.5; 11.8] ng/ml, respectively (p<0.05). 12 and 24 weeks after the first infusion of the original RTM, there was a statistically significant decrease in the concentration of MMP-3, amounting to 80% of the initial level. Against the background of the use of the RTM biosimilar, after 12 and 24 weeks, a statistically significant decrease in the concentration of MMP-3 was observed, which was 46.8 and 59% of the basal level, respectively. According to the ROC analysis, it was found that the basal level of IL-6 more than 100.0 pg/ ml and the level of MMP-3 more than 78.6 ng/ml were associated with the preservation of inflammatory activity by the 24th week of therapy with the RTM biosimilar with a sensitivity of 85% and 57% and a specificity of 62% and 61.5%, respectively. Conclusion. Determining the level of MMP-3 in patients receiving anti-B-cell therapy is important for a more objective assessment of disease activity and predicting the effectiveness of treatment. Key words: rheumatoid arthritis, matrix metalloproteinase 3, anti-B-cell therapy, rituximab biosimilar>˂ 0.05). 12 and 24 weeks after the first infusion of the original RTM, there was a statistically significant decrease in the concentration of MMP-3, amounting to 80% of the initial level. Against the background of the use of the RTM biosimilar, after 12 and 24 weeks, a statistically significant decrease in the concentration of MMP-3 was observed, which was 46.8 and 59% of the basal level, respectively. According to the ROC analysis, it was found that the basal level of IL-6 more than 100.0 pg/ ml and the level of MMP-3 more than 78.6 ng/ml were associated with the preservation of inflammatory activity by the 24th week of therapy with the RTM biosimilar with a sensitivity of 85% and 57% and a specificity of 62% and 61.5%, respectively.Conclusion. Determining the level of MMP-3 in patients receiving anti-B-cell therapy is important for a more objective assessment of disease activity and predicting the effectiveness of treatment.
IMPLEMENTASI KONSEP 4C DALAM PEMBELAJARAN PADA MATA KULIAH ANALISIS KEBIJAKAN PENDIDIKAN
Authors: Anas Azwar , Mujahidin Endin 
Published: September 2022

Di abad 21 peserta didik harus memiliki keterampilan dan mengembangkan potensinya, agar mereka menjadi pribadi yang sukses dan berkembang dalam kehidupannya. Di antara keterampilan abad 21 adalah keterampilan 4C (Critical thinking, communication, collaboration, creativity). Terdapat banyak pendapat tentang apa saja keterampilan abad ke-21, salah satu pendapat adalah 4C (Critical thinking, Creativity, Collaboration, dan Communication). Critical thinking (berpikir kritis) adalah semua hal tentang keterampilan memecahkan masalah. Creativity (kreativitas) adalah hal tentang keterampilan berpikir outside the box, mencoba pendekatan baru untuk menyelesaikan sesuatu, inovasi, dan penemuan. Collaboration (kolaborasi) adalah keterampilan bagaimana seseorang bekerja sama, saling bersinergi, beradaptasi dalam berbagai peran dengan orang lain untuk mencapai tujuan bersama. Communication (komunikasi) adalah keterampilan seseorang untuk menyampaikan dan berbagi pemikiran, pertanyaan, gagasan, dan solusi mereka dengan cara terbaik. Tulisan ini akan memaparkan berbagai keterampilan tersebut agar dapat memberikan tambahan wawasan dan pengembangan keterampilan sehingga dapat bermanfaat dalam menyiapkan anak didik untuk menghadapi perubahan jaman yang tak terelakkan
Fluvial activity of the late-glacial to Holocene “Bergstraßenneckar” in the Upper Rhine Graben near Heidelberg, Germany – first results
Authors: Engel Max , Henselowsky Felix , Roth Fabian , Kadereit Annette , Herzog Manuel , Hecht Stefan , Lindauer Susanne , Bubenzer Olaf , Schukraft Gerd 
Published: September 2022

Abstract. The term “Bergstraßenneckar” (BSN) refers to an abandoned course of the river Neckar. It flowed
in a northern direction east of the river Rhine in the eastern part of the
northern Upper Rhine Graben in southwestern Germany. The former meandering
course merged with the Rhine ca. 50 km further north of the site of the
present-day confluence near Mannheim. The palaeo-channels are still
traceable by their depressional topography, in satellite images and by the curved boundaries of
adjacent settlements and land parcels. In the plan view, satellite and
aerial images reveal a succession of meander bends, with older bends being
cut off from younger channels. Based on stratigraphic investigations of the
channel infill in the northern part of the BSN, fluvial activity is assumed
from ca. 14 500 years ago until the onset of the Holocene. We present
results of the first stratigraphic investigations at two sites in the
southern part of the BSN near Heidelberg (Rindlache, Schäffertwiesen),
together with results from granulometric, carbonate and organic content analyses, as well as
electrical resistivity tomography (ERT) measurements. The data clearly show
a change from high-energy fluvial bedload (sand, gravel) to low-energy
fluvio-limnic suspended load (organoclastic and calcareous mud) and to peat
formation. Radiocarbon dating indicates a time lag of ca. 1500 years between
the cut-off meander site (Schäffertwiesen) and the younger site
(Rindlache) that was possibly still active until the present-day confluence
near Mannheim was established and the BSN eventually became abandoned. Our
preliminary data conform with the pedo-sedimentary evidence from the
northern BSN, but slight differences in the stratigraphic pattern of the
youngest channels are identified: whilst for the younger channel
sections of the northern BSN the channel-bottom facies (sand, gravel) is
directly overlain by peat, the channel at Rindlache shows substantial
intervening mud deposition, which is interpreted as suspension load from
flooding by the new Neckar channel nearby. The study shows that more
chronostratigraphic data from channel sections of the southern BSN are
needed to better constrain the timing of the fluvial activity and to
decipher the reasons for the abandonment of the BSN. These data are also
necessary to better understand the pattern of temporary reactivation of the
BSN channels across the Holocene and their usage by humans, which can be
deduced from historical sources and archaeological data.
Analysis of the evolution of the Brazilian sugar-energy sector from the 1995, 2006 e 2017 Agricultural Censuses
Authors: Cattelan Renata , Francisco Assis Shikida Pery 
Published: September 2022

Given the historical importance of sugarcane for Brazil and considering that it continues to stand out in national agribusiness, it is important to investigate the interfaces of this activity. The objective was to analyze the changes that have occurred in the productive aspects of sugarcane, comparing the data from the 2017 Agricultural Census against 2006 and 1995. The results showed that the sector continues to represent great importance for Brazilian agriculture. In addition, the Midwest has stood out as a new producing region, with emphasis on Goiás, which came to occupy the second position in the quantity produced among the states in the 2017 Census. The Southeast continues to lead the production, with more than 60% of the Brazilian total, with São Paulo stands out. Considering the references consulted and the results found, the states that are leading the sugarcane market have greater technological capacity, aiming at productive sustainability and efficiency of processes, especially in terms of agricultural yields.
URGENSI SUMBER DAN MEDIA PEMBELAJARAN LABORATORIUM PADA SISWA MADRASAH ALIYAH
Authors: Aulya Zahwatun Nisa  
Published: September 2022

Learning resources and media are currently very helpful in the learning process. One that can be used as a source and learning media effectively is the laboratory. The laboratory has a very important role in learning at the senior secondary level such as Madrasah Aliyah. The purpose of writing this article is to determine the urgency of laboratory learning media and sources as well as the role of laboratories in madrasah aliyah. This research uses a qualitative approach. The method used is the case study method with descriptive analysis techniques. Data collection techniques in this study are observation and interviews. This research was conducted at Madrasah Aliyah Nahdlatul Ulama Kepuharjo Karangploso. The application of practical methods / scientific methods to Islamic madrasah learning requires a laboratory as a means or a place to carry out practical activities. The use of laboratories or practical activities is part of the teaching and learning process. In addition, laboratories can help students to better understand something that is conveyed by educators. Moreover, the use of laboratories for students at the madrasah aliyah level, which later students can use various laboratory facilities for practical activities according to the subject directly. Thus, the laboratory has an important role as a source and medium of learning so that teaching and learning practicum activities run well.
Keyword: Urgency of learning resources, Laboratory, Madrasah aliyah
IMPLEMENTASI MANAJEMEN PEMBIAYAAN PENDIDIKAN TPQ ROUDLOTUT THOLAB
Authors: Surur Agus Miftakus , Sanjaya Maulana 
Published: September 2022

This study aims to find out about how the implementation of financing management in non-formal educational institutions, namely TPQ. The study conducted research at a TPQ named TPQ Roudlotut Tholab. The research method used is a qualitative research method using a PAR (Participatory action research) approach. The researcher used the approach because the researcher went directly to the research location, namely TPQ Roudlotut Tholab. In this research, the researcher uses secondary data and primary data provided by one of the administrators at TPQ Roudlotut Tholab. The results in this study are the source of funds for TPQ Roudlotut Tholab comes from infaq of the guardians of students at TPQ Roudlotut Tholab and also assistance from the government. Budget management at TPQ Roudlotut Tholab is also very good, this can be seen from the meetings that are often held by the students of TPQ Roudlotut Tholab before entering the new school year. In terms of the use of the financing budget at the Roudlotut Tholab TPQ, it doesn't cost too much, but during this COVID-19 pandemic, the spending budget at the Roudlotut Tholab TPQ is very large, especially if you have to comply with health protocols. TPQ Roudlotut Tholab in carrying out the health protocol to buy buckets and hand washing soap, this was done because he wanted to break the chain of the spread of Covid-19, which spread so quickly in our country, Indonesia.
Keyword: Management, Financing, Education, TPQ
DAMPAK MENTAL HECTIC BAGI PERKEMBANGAN EMOSI ANAK PADA MASA PANDEMI COVID-19 DI KABUPATEN PROBOLINGGO
Authors: Debby Adelita Febrianti Purnamasari  
Published: September 2022

Mental hectic is instability or a disturbance in a person's mental, can be early childhood, adolescents and adults. Mental hectic in children is due to learning activities that are far from the nature of children's learning, namely playing and having fun. Children's emotional development includes recognizing what feelings and emotions they are experiencing, understanding how and why they occur, recognizing their own feelings and those of others, and developing effective ways of managing them. The purpose of this study is to identify the mental hectic that occurs in early childhood. The second goal is to identify children's emotional development. The third objective is to identify the impact of hectic mentality on children's emotional development. The approach used in this research is qualitative phenomenology. The survey was conducted on the child's environment and experiences. The results of this study are the environment around the child is the cause of mental hectic and has an impact on the child's emotional development. Some children aged 3-6 years were identified as experiencing mental hectic which caused poor emotional development. More dominant negative emotions shown by children.
Keyword: Mental Hectic, Emotional Development
EFEKTIFITAS PEMBELAJARAN DARING DENGAN E-MODUL TERINTEGRASI GOOGLE EDUCATION PADA MATA PELAJARAN MATEMATIKA KELAS VIII
Authors: Darwin Djeni  , Jamiatun Nasikhah  
Published: September 2022

Student interest in class VII SMP NAMIRA Kota Probolinggo on subject Mathematics is classified as low, especially when the subject mathematics fells like it’s always being skipped. This is an accordance with the results of diagnostic Assesment and learning interest of 60 students, the percentage of high interest in learning Mathematics subject, only 30 %. Mathematics is a subject that is considered difficult. It is a challenge to present on pandemic or daring of learn it in an must attractive, easy and fun away. Solution to overcome this problem is through the implementation of google education integrated e-book. The purpose os this study was to determine effectivity of implementation of google education integrated e-book on class VII SMP NAMIRA Kota Probolinggo. The research method used is Mathematics Realistic integrated discovery learning that present on e book. E-book that created with Bookcreator application mix google education. Data collection techniques used were test of students understanding, attitude assessment, observation (quisoner), reflection learning of Mathematics. The results showed that the implementation of google education integrated e book is effective with interest Matematics subject increasing 55,6% on the first meet, the second meet to be 83% . Students learning outcomes describe student interest to follow learning of Mathematics, it is shown assignment collection and result show 10 % under KKM Mathematics subject.
Keywords: e-book, Bookcreator, Google Education, FAAST
PENERAPAN STRATEGI EVERYONE IS TEACHER HERE DALAM MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR PADA MATA PELAJARAN SOSIOLOGI KELAS X-A DI MAN 1 KOTA PROBOLINGGO
Authors: Babul Bahrudin  
Published: September 2022

Learning strategies are a way for teachers to make the class more active. The use of learning strategies will make it easier for teachers to manage the class and increase motivation and learning achievement. One of the learning strategies that can be chosen by teachers is the Everyone Is a Teacher Here strategy which requires students to be more active, encourage learning motivation and improve student achievement. This study aims to 1) examine the implementation of the Everyone Is a Teacher Here strategy in increasing motivation and learning achievement in Sociology subjects in class X-A at MAN 1 Probolinggo City. 2) examine whether the implementation of the Everyone Is a Teacher Here strategy can increase motivation and learning achievement in the Sociology subject class X-A at MAN 1 Probolinggo City.
This research is classroom action research (CAR) using a descriptive qualitative approach. Methods of data collection using the method of observation, interviews and documentation. From the two cycles that were applied, it can be seen in the evaluation of the post test scores, the average student got a good score. In the first cycle, the pre-test was 63%, in the second cycle, the post-test was carried out with an average value of 79.61%. This means that the students are enthusiastic in learning and the Everyone Is a teacher Here strategy has succeeded.
Keyword: Learning Strategy, Motivation, Learning Achievement, Everyone Is a Teacher Here
THE EFFECT OF HALAL AWARENESS, RELIGIOSITY, PRODUCT INGREDIENTS KNOWLEDGE, AND HALAL CERTIFICATION ON THE PURCHASE DECISION OF HALAL FAST FOOD
Authors: Syifana Ghita Santosa  , Muhamad Rizky Rizaldy  
Published: September 2022

Introduction: Indonesia has become a country with the largest Muslim population in the world. As a Muslim majority population, it is very important to consume halal products that are in accordance with the Qur'an and Sunnah. But in fact, not all products consumed by Muslims have halal certification. Along with the increasing identity of the Muslim community, the current halal lifestyle has become a trend that is in great demand, including the demand of halal fast food. This study aims to analyze the effect of halal awareness, religiosity, knowledge of product ingredients and halal certification in purchasing decisions of halal fast food products.
Methods: The data used is primary data collected by using a questionnaire. The analytical technique used is multiple linear regression using the SPSS version 25 application.
Results: This study found that the variables of halal awareness (X₁), religiosity (X2), product material knowledge (X3), and halal certification (X4) significantly influenced the decision to purchase halal fast food by 66%. This research produces a multiple linear regression equation as follow: Y=5.073 + 0.318X₁ + 0.106X₂ + 0.137X₃ + 0.351X₄ + e.
Conclusion and suggestion: The implications of this research are given to producers and consumers of fast food to consider the importance of halal certification, which starts from awareness of consuming halal products which are then expected to be committed to their religion. With this research, it is hoped that there will be an increase in halal certification in fast food, especially in Indonesia, one of which is through incessant socialization of the importance of halal certification in fast food.
Keywords: Halal Awareness, Religiosity, Knowledge of Product Ingredients, Halal Certification of Fast Food.
Penerapan Akad Nadzar Pada Pembiayaan Qardh (Studi Pada Koperasi BMT Maslahah Jawa Timur)
Authors: Saifuddin Syuhri  , Abd Ghafur  
Published: September 2022

Introduction: Makalah ini menggunakan pendekatan analisis kualitatif dengan meninjau literatur dan mewawancarai anggota yang mendapatkan pembiayaan qard, untuk mendapatkan informasi tentang fleksibilitas dan kenyamanan akad nadzar serta menetapkan informan ahli sebagai sumber utama yaitu kepala cabang, Direktur, Direktur Utama, Pengurus dan Pengawas BMT Maslahah di 100 kantor cabang yang berkedudukan di wilayah kecamatan, kota kabupaten wilayah propinsi jawatimur. Pengurus Cabang Nahdlatul Ulama’, Pengurus Majlis Ulama’ Indonesia cabang, Pengurus syuriyah Nahdlatul Ulama’, dan beberapa tokoh masyarakat. Wawancara difokuskan pada produk pembiayaan qardh dengan menerapkan akad nadzar kepada anggotauntuk mempresentasikan pandangan para praktisi terkait penerapanakad nadzar pada pembiayaan qardh.
Methods: Desain/Metodologi/pendekatan
Result: Studi ini menemukan bahwa BMT Maslahah mempunyai model penerapan akad nadzar pada pembiayaan qardmemberikan pemahaman dan kemudahan serta kenyamanan pada anggota. Penerapan akad nadzar pada pembiayaan qardh adalah merupakan produk akad baru yang menjadi alternatif akadyang dapat dijelaskan dalam penelitian ini.
Conclusion and suggestion: Temuan penelitian ini menambah literatur tentang penerapan akad nadzar pada pembiayaan qardh di BMTdengan memungkinkan peneliti dan praktisi untuk menelaah terhadap penerapan akad nadzar.Temuan ini juga berkontribusi untuk memperkaya pengetahuan tentang akad-akad pada BMTdan kebutuhan pembiayaan anggota. juga memberikan kontribusi pada bidang ekonomi Islam khususnya kepada Dewan Syariah Nasional Majelis Ulama Indonesia.
Keywords: Akad Nadzar,Pembiayaan Qardh, BMT
METODE RGEC MENJADI TOLAK UKUR TINGKAT KESEHATAN BANK
Authors: Moh. Abd. Rahman  
Published: September 2022

Background: Banks are the backbone of the economic and financial system in Indonesia as the channeling back of funds owned by excess economic units to economic units that need funds or deficits. The RGEC method is a structured way of assessing bank health compared to the previous valuation method, CAMELS. In article 2 paragraph (3) BI regulation No. 13/1 / PBI / 2011 concerning health assessment of commercial banks including risk profile, good corporate governance, earnings, and capital.
Method: Document review is one of the research methods by comparing standards with financial statement documents to be examined. The documents that will be reviewed include the report on financial position, income statement and Good Corporate Governance report. The data that will be used in this study are quantitative data types. Quantitative data is numeric data such as financial position reports, income statements and other measurable data.
Research Result: Seen from the four aspects measured in the form of risk profile, GCG, earnings, and capital as a whole are ranked very healthy even though there are differences in the value of the composite in each study year either overall BUKU IV Bank or individual banks, for the most consistent banks within the Bank BUKU IV category, according to the researchers, is BRI Bank because the composite value obtained by BRI each year is not too much different.
Conclusion: The results of the analysis of the soundness of Bank BUKU IV namely BRI, BNI, Mandiri, BCA, and CIMB Niaga based on the RGEC method from 2012 to 2018 show that the bank's performance is in the Composite Rating 1 (PK-1) which means Bank BUKU IV is located in very healthy condition.
Keywords: Bank Health, RGEC, BUKU
SISTEM KEUANGAN SYARIAH PADA UMKM DI DESA JATIURIP KECAMATAN KREJENGAN PROBOLINGGO
Authors: Moh. Samsul Arifin  
Published: September 2022

Introduction: A good Islamic financial management system is very meaningful for UMKM in carrying out their business so that industrial values ​​and profits can be optimized, prosperity is formed, industrial image is created, and industrial responsibilities are carried out
Methods: The research method used is qualitative metode using primary data sources through interviews about data and information related to research. System of Islamic financing for UMKM in Jatiurip Krejengan Probolinggo Regarding the method of implementation, interviews are divided into 3 types, namely: freelance interviews, guided interviews, free guided interviews, interviews as a means of data collection, and at the same time collecting data.
Results: The results of this research activity indicate that the reporting of sharia-based financial systems for MSMEs is not optimal and financial reports are very important in order to understand the role and benefits of implementing Islamic financial management for MSME business implementation.
Conclusion and suggestion: It is hoped that UMKM will be able to make financial reports with national accounting standards so they can analyze profit and loss and manage Islamic finance.
Keywords: UMKM, Islamic Financial Management, Implementation