bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of psychological first aid program on stress level and psychological well-being among caregivers of older adults with alzheimer’s disease
Authors: Shoukr Eman Mahmoud Mohammed , Mohamed Abeer Abd El-Rahman , El-Ashry Ayman Mohamed , Mohsen Heba Ahmed 
Published: October 2022

Abstract
Introduction
Older adults with Alzheimer’s disease (AD) experience drastic changes in their physical and mental abilities. AD patients became heavily dependent on their caregivers for everyday functions, which have significant implications not only for them but also for their caregivers. So, many AD caregivers experienced an increased level of depression and anxiety symptoms, lower perceived control, and higher burden compared to non-AD caregivers. Therefore, psychological first aid (PFA) and educational interventions are designed to enable those caregivers to meet the daily requirements of their patient care and to cope with its challenges.

Aim
Determine the effect of psychological first aid program on stress level and psychological well-being among caregivers of older adults with Alzheimer’s disease.

Design
One group pre-test post-test was followed.

Subjects
A convenience sample of one hundred (100) caregivers of older adults with AD.

Setting
All online groups concerned with the care of Alzheimer’s disease patients on Facebook.

Tools
Socio-demographic and clinical data of older adults with Alzheimer’s disease and their caregivers’ questionnaire, Alzheimer’s disease knowledge scale, Kingston caregiver stress scale, and authentic identity measures (AIM) scale of psychological well-being

Results
The psychological first aid program has highly statistically significant effect on the AD caregivers’ knowledge, stress level and psychological well-being as (t=-30.707, P = 0.000, t = 8.500, P = 0.000 & t= -4.763, P = 0.000 respectively).

Conclusion
Psychological first aid program is considered an effective intervention in decreasing the AD caregivers’ stress and increasing their psychological wellbeing and knowledge regarding delivering care for AD patients.
New strategies to improve clinical outcomes for diabetic kidney disease
Authors: Forst Thomas , Mathieu Chantal , Giorgino Francesco , Wheeler David C. , Papanas Nikolaos , Schmieder Roland E. , Halabi Atef , Schnell Oliver , Streckbein Marina , Tuttle Katherine R. 
Published: October 2022

AbstractBackgroundDiabetic kidney disease (DKD), the most common cause of kidney failure and end-stage kidney disease worldwide, will develop in almost half of all people with type 2 diabetes. With the incidence of type 2 diabetes continuing to increase, early detection and management of DKD is of great clinical importance.Main bodyThis review provides a comprehensive clinical update for DKD in people with type 2 diabetes, with a special focus on new treatment modalities. The traditional strategies for prevention and treatment of DKD, i.e., glycemic control and blood pressure management, have only modest effects on minimizing glomerular filtration rate decline or progression to end-stage kidney disease. While cardiovascular outcome trials of SGLT-2i show a positive effect of SGLT-2i on several kidney disease-related endpoints, the effect of GLP-1 RA on kidney-disease endpoints other than reduced albuminuria remain to be established. Non-steroidal mineralocorticoid receptor antagonists also evoke cardiovascular and kidney protective effects.ConclusionWith these new agents and the promise of additional agents under clinical development, clinicians will be more able to personalize treatment of DKD in patients with type 2 diabetes.
Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis
Authors: Renaud Emilie , Riegel Kristina , Romero Rossana , Suryamohan Kushal , Distler Ute , Tenzer Stefan , Schad Arno , Musholt Thomas J. , Rajalingam Krishnaraj 
Published: October 2022

Abstract
Background
Papillary thyroid carcinoma (PTC) is one of the most common forms of thyroid cancer with a cure rate of over 90% after surgery. However, aggressive forms may still occur, and personalized therapeutic strategies are increasingly required.

Methods
We performed integrated genomic and proteomic analysis of PTC tumor samples from patients who did not harbor BRAF or RAS mutations. We validate the analysis and present in-depth molecular analysis of the identified genetic rearrangement by employing biochemical and cell biological assays. Finally, we employ 3D spheroid models, loss of function studies and chemical inhibitors to target the hitherto upregulated factors. The data are analysed with appropriate statistical tests which are mentioned in the legends section.

Results
In a 23-year-old patient with thyroiditis, we identified a novel rearrangement leading to a BAIAP2L1-BRAF fusion that transforms immortalized human thyroid cells in a kinase and CC-domain dependent manner. Moreover, quantitative proteomic analysis of the same patient samples revealed the upregulation of several proteins including the Ubiquitin E3 ligase TRIM25, PDE5A, and PKCδ. Further, in a cohort of PTC patients, we observed higher expression of TRIM25 and PKCδ in the tumor and metastatic lesions, when compared to the matched normal tissue. Inhibition of TRIM25, PDE5A and PKCδ with small molecules or RNA interference affected not only viability and proliferation of BAIAP2L1-BRAF transformed cells, but also the viability, growth and invasion of corresponding 3D spheroid cultures.

Conclusions
Apart from unveiling a novel oncogenic BRAF fusion in PTCs, our data may open a novel avenue of therapeutic targeting in human PTCs.
High platelet-to-lymphocyte ratios in triple-negative breast cancer associates with immunosuppressive status of TILs
Authors: Onagi Hiroko , Horimoto Yoshiya , Sakaguchi Asumi , Ikarashi Daiki , Yanagisawa Naotake , Nakayama Takayuki , Nakatsura Tetsuya , Ishizuka Yumiko , Sasaki Ritsuko , Watanabe Junichiro , Saito Mitsue , Saeki Harumi , Hayashi Takuo , Arakawa Atsushi , Yao Takashi , Kitano Shigehisa 
Published: October 2022

AbstractBackgroundRating lymphocytes (TILs) are a prognostic marker in breast cancer and high TIL infiltration correlates with better patient outcomes. Meanwhile, parameters involving immune cells in peripheral blood have also been established as prognostic markers. High platelet-to-lymphocyte ratios (PLRs) and neutrophil-to-lymphocyte ratios (NLRs) are related to poor outcomes in breast cancer, but their mechanisms remain unknown. To date, TILs and these parameters have been examined separately.MethodsWe investigated the relationship between TILs and the peripheral blood markers, PLR and NLR, in the same patients, using surgical specimens from 502 patients with invasive breast carcinoma without preoperative chemotherapy. For analysis of triple-negative breast cancer (TNBC) patient outcomes, 59 patients who received preoperative chemotherapy were also examined. For immune cell profiling, multiplexed fluorescent immunohistochemistry (mfIHC) of CD3, CD4, CD8, FOXP3 and T-bet, was conducted.ResultsA positive correlation between PLR and TIL was observed in TNBC (P = 0.013). On mfIHC, tumors in patients with high PLR and NLR contained more CD3+CD4+FOXP3+T-cells (P = 0.049 and 0.019, respectively), while no trend was observed in CD8+T-cells. TNBC patients had different patterns of outcomes according to TIL and PLR, with the TIL-high/PLR-low group having the lowest rate of disease relapse and death, and the longest distant metastasis-free and overall survivals, while the TIL-low/PLR-high group had the shortest survivals.ConclusionsOur data suggest that the combination of PLR with TIL assessment may enable more accurate prediction of patient outcomes with TNBC.
Contact osteogenesis by biodegradable 3D-printed poly(lactide-co-trimethylene carbonate)
Authors: Hassan Mohamad Nageeb , Yassin Mohammed Ahmed , Eltawila Ahmed Maher , Aladawi Ahmed Emad , Mohamed-Ahmed Samih , Suliman Salwa , Kandil Sherif , Mustafa Kamal 
Published: October 2022

Abstract

Background
To support bone regeneration, 3D-printed templates function as temporary guides. The preferred materials are synthetic polymers, due to their ease of processing and biological inertness. Poly(lactide-co-trimethylene carbonate) (PLATMC) has good biological compatibility and currently used in soft tissue regeneration. The aim of this study was to evaluate the osteoconductivity of 3D-printed PLATMC templates for bone tissue engineering, in comparison with the widely used 3D-printed polycaprolactone (PCL) templates.

Methods
The printability and physical properties of 3D-printed templates were assessed, including wettability, tensile properties and the degradation profile. Human bone marrow-derived mesenchymal stem cells (hBMSCs) were used to evaluate osteoconductivity and extracellular matrix secretion in vitro. In addition, 3D-printed templates were implanted in subcutaneous and calvarial bone defect models in rabbits.

Results
Compared to PCL, PLATMC exhibited greater wettability, strength, degradation, and promoted osteogenic differentiation of hBMSCs, with superior osteoconductivity. However, the higher ALP activity disclosed by PCL group at 7 and 21 days did not dictate better osteoconductivity. This was confirmed in vivo in the calvarial defect model, where PCL disclosed distant osteogenesis, while PLATMC disclosed greater areas of new bone and obvious contact osteogenesis on surface.

Conclusions
This study shows for the first time the contact osteogenesis formed on a degradable synthetic co-polymer. 3D-printed PLATMC templates disclosed unique contact osteogenesis and significant higher amount of new bone regeneration, thus could be used to advantage in bone tissue engineering.
Attitudes Toward Striving for Quality and Length of Life Among Patients With Advanced Cancer and a Poor Prognosis
Authors: van der Velden Naomi C.A. , van Laarhoven Hanneke W.M. , Nieuwkerk Pythia T. , Kuijper Steven C. , Sommeijer Dirkje W. , Ottevanger Petronella B. , Fiebrich Helle-Brit , Dohmen Serge E. , Creemers Geert-Jan , de Vos Filip Y.F.L. , Smets Ellen M.A. , Henselmans Inge 
Published: October 2022

PURPOSE: When deliberating palliative cancer treatment, insight into patients' attitudes toward striving for quality of life (QL) and length of life (LL) may facilitate goal-concordant care. We investigated the (1) attitudes of patients with advanced cancer toward striving for QL and/or LL and whether these change over time, and (2) characteristics associated with these attitudes (over time). METHODS: We performed a secondary analysis of a randomized controlled trial on improving shared decision making (SDM), without differentiation between intervention arms. Patients (n = 173) with advanced cancer, a median life expectancy of < 12 months without anticancer treatment, and a median survival benefit of < 6 months from systemic therapy were included in seven Dutch hospitals. We used audio-recorded consultations and surveys at baseline (T0), shortly after the consultation (T2), at 3 and 6 months (T3 and T4). Primary outcomes were patients' attitudes toward striving for QL and LL (Quality Quantity Questionnaire; T2, T3, and T4). RESULTS: Overall, patients' attitudes toward striving for QL became less positive over 6 months ( P < .01); attitudes toward striving for LL did not change on group level. Studying individual patients, 76% showed changes in their attitudes toward striving for QL and/or LL at some point during the study, which occurred in various directions. More helplessness/hopelessness ( P < .001), less fighting spirit ( P < .05), less state anxiety ( P < .001), and more observed SDM ( P < .05) related to more positive attitudes toward striving for QL. Lower education, less helplessness/hopelessness, more fighting spirit, and more state anxiety ( P < .001) related to more positive attitudes toward striving for LL. CONCLUSION: Oncologists may explore patients' attitudes toward striving for QL and LL repeatedly and address patients' coping style and emotions during SDM to facilitate goal-concordant care throughout the last phase of life.
Radiotherapy-Associated Pelvic Insufficiency Fracture Treated by Romosozumab: Course of CT Attenuations at L1 and L5
Authors: Schneider Gary K , Ing Steven W 
Published: October 2022

Abstract
Pelvic radiation therapy (RT) is a risk factor for pelvic insufficiency fracture, which may be accompanied by significant pain, decreased self-sufficiency, and impaired mobility. Assessment of bone density with “opportunistic” computed tomography (CT) attenuation of the L1 vertebral body can be used as a surrogate for dual-energy x-ray absorptiometry (DXA) scan and potentially be useful to follow bone changes in cancer patients who undergo surveillance CT imaging. The following is a case of a 60-year-old female who suffered a pelvic insufficiency fracture, after receiving chemotherapy and pelvic RT for endometrial cancer, for which she was treated with romosozumab, a sclerostin inhibitor used for postmenopausal women at high risk for insufficiency or fragility fracture. CT attenuation of the L1 and L5 vertebral bodies were measured prior to chemoradiation therapy, post-therapy, and before and after treatment with romosozumab. Pelvic RT was associated with declining CT attenuation, greater in magnitude at L5 vs L1 vertebral body, while treatment with romosozumab was associated with increase to baseline at L1, and improvement but not return to baseline at L5.
Menu Engineering for Continuing Care Senior Living Facilities with Captive Dining Patrons
Authors: Kulturel-Konak Sadan , Konak Abdullah , Jakielaszek Lily , Gavirneni Nagesh 
Published: October 2022

Continuing care facilities are a rapidly growing segment of senior living communities providing end-to-end solutions comprising independent living, assisted living, nursing home care, and ultimately hospice. All these establishments contain (in addition to other facilities associated with living, exercising, learning, activities, etc.) dining services managed by an interdisciplinary (finance, nutrition, dietitian, kitchen operations, hospitality, and procurement) team of executives, each with their own objective while cognizant of the overarching organizational, operational, and financial metrics. The residents of these facilities consume most of their meals at these dining facilities, necessitating that the food served meets the complete nutrition, dietary, cost, and operational requirements. Thus, the menu (often rotating every few weeks) of food items must be carefully chosen to be efficiently procured, processed, and served, all the while meeting the nutritional, dietary, and patron satisfaction constraints each put forth by the corresponding stakeholder. We address this complex, unwieldy, and large multiobjective optimization problem using mixed integer linear programming. We demonstrate how menu planners and chefs can analyze their decisions regarding menu structures and evaluate alternative menu interventions to improve menus’ nutritional value while ensuring their residents’ autonomy in making food choice decisions. Along the way, we interviewed various stakeholders, identified their objectives and constraints, gathered the necessary data, formulated and solved the resulting optimization problems, and produced demonstrably effective menus. History: This paper was refereed. This paper was accepted for the Special Issue of INFORMS Journal on Applied Analytics—Decision Analysis.
Iteration Complexity of a Proximal Augmented Lagrangian Method for Solving Nonconvex Composite Optimization Problems with Nonlinear Convex Constraints
Authors: Kong Weiwei , Melo Jefferson G. , Monteiro Renato D. C. 
Published: October 2022

This paper proposes and analyzes a proximal augmented Lagrangian (NL-IAPIAL) method for solving constrained nonconvex composite optimization problems, where the constraints are smooth and convex with respect to the order given by a closed convex cone. Each NL-IAPIAL iteration consists of inexactly solving a proximal augmented Lagrangian subproblem by an accelerated composite gradient method followed by a Lagrange multiplier update. Under some mild assumptions, a complexity bound for NL-IAPIAL to obtain an approximate stationary solution of the problem is also derived. Numerical experiments are also given to illustrate the computational efficiency of the proposed method. Funding: This work was supported by the Natural Sciences and Engineering Research Council of Canada [Grant PGSD3-516700-2018]; Conselho Nacional de Desenvolvimento Científico e Tecnológico [Grant 312559/2019-4]; Fundação de Amparo à Pesquisa do Estado de Goiás; Office of Naval Research [Grant N00014-18-1-2077]; Exascale Computing Project [Grant 17-SC-20-SC]; Air Force Office of Scientific Research [Grant FA9550-22-1-0088]; UT-Battelle, LLC [Grant DE-AC05-00OR22725].
Value Creation Tradeoff in Business Ecosystems: Leveraging Complementarities While Managing Interdependencies
Authors: Agarwal Shiva , Kapoor Rahul 
Published: October 2022

Complementary assets play an important role in shaping an innovation’s commercialization success. In this paper, we broaden the locus of complementarities to examine the role of complementary technologies residing in the business ecosystems that are becoming an important source of value creation for innovating firms. We argue that, on one hand, complementary technologies help innovations create more value for their users. On the other hand, they can also limit the focal innovation’s value creation by exposing them to performance bottlenecks as the underlying technological architecture of the ecosystem evolves. We further extend the notion of specialization of complementary assets to ecosystems by considering complementary technologies that are specialized to a focal ecosystem and those that are available across multiple ecosystems. We highlight that, although the complementary technologies that are specialized to an ecosystem facilitate greater value creation, they are more likely to subject the focal innovation to performance bottlenecks. Evidence from 244,034 apps launched by software developers for Apple’s iPhone ecosystem during 2008–2015 offers strong support for our framework. In summary, the study sheds light on the value creation tradeoff for firms innovating in business ecosystems—the opportunities associated with leveraging complementarities and the challenges associated with managing technological interdependencies. Funding: S. Agarwal was funded by the McCombs School of Business at The University of Texas at Austin [Research Excellence Grant].
Pengelolaan Keuangan Sekolah Di Masa Pandemi : Studi Kasus SMA Negeri Di Manggelewa Dompu
Authors: Haryadi Didit , Blatama Della , Rangga Rangga 
Published: October 2022

Pada masa pandemi sekarang tentu sekolah harus lebih pintar mengelola karena masalah sekarang bukan saja masalah beberapa instansi tapi banyak Instansi banyak merasakan dampak dari pengelolaan keuangan pada masa pandemi ini. Adapun tujuan penelitian ini adalah (1) untuk melihat pengelolaan biaya investasi (2) untuk melihat pengelolaan biaya Personal (3) untuk melihat pengelolaan biaya Operasional di SMA Negeri 1 Manggelewa.

Penelitian ini merupakan penelitian Kualitatif dengan Pendekatan Studi Kasus. Alasan peneliti memilih studi kasus karena jenis pendekatan ini sangat cocok untuk menggambarkan keadaan dan situasi di SMA Negeri 1 Manggelewa yang merupakan tempat penelitian. Subjek pada penelitian ini adalah Kepala sekolah, Bendahara dan Beberapa guru yang bersedia untuk diwawancarai. Teknik pengumpulan data pada penelitian ini menggunakan wawancara dengan Triangulasi sumber. Teknik analisis dengan menggunakan Model Miles Huberman

Dari Penelitian dapat disimpulkan: (1) Biaya Investasi terkait gaji guru tidak ada perbedaan di SMA Negeri 1 Manggelewa baik sebelum pandemi dan masa pandemi pengembangan SDM juga sangat baik karena guru memanfaatkan IT untuk mendukung kegiatan pembelajaran pada masa pandemi ini (2) Biaya Personal terkait pembayaran yang dilakukan peserta didik terjadi perbedaan sebelum pandemi awalnya 60 Ribu dan masa pandemi ini 50 Ribu per bulan terjadi penurunan biaya terkait pembayaran peserta didik pada masa pandemi ini (3) biaya Operasional pada SMA Negeri 1 Manggelewa penggunaan yang paling banyak adalah penggunaan air dan kuota internet belajar. Penggunaan air di gunakan untuk mencuci tangan siswa dan kuota belajar untuk proses belajar.
Level of dietary adherence and determinants among type 2 diabetes population in Ethiopian: A systemic review with meta-analysis
Authors: Abate Teshager Weldegiorgis , Tareke Minale , Abate Selam , Tegenaw Abebu , Birhanu Minyichil , Yirga Alemshet , Tirfie Mulat , Genanew Ashenafi , Gedamu Haileyesus , Ayalew Emiru 
Published: October 2022

Background
The beneficial effect of the dietary practice is significant reduction in the risk of developing diabetes related complication. Dietary practice among type 2 diabetes is not well-implemented in Ethiopia. Up to now, in the nation, several primary observational studies have been done on dietary adherence level and its determinants among type 2 diabetes. However, a comprehensive review that would have a lot of strong evidence for designing intervention is lacking. So, this review with a meta-analysis was conducted to bridge this gap.

Methods
A systematic review of an observational study is conducted following the PRISMA checklist. Three reviewers have been searched and extracted from the World Health Organization- Hinari portal (SCOPUS, African Index Medicus, and African Journals Online databases), PubMed, Google Scholar and EMBASE. Articles’ quality was assessed using the Newcastle-Ottawa Scale by two independent reviewers, and only studies with low and moderate risk were included in the final analysis. The review presented the pooled proportion dietary adherence among type2 diabetes and the odds ratios of risk factors favor to dietary adherence after checking for heterogeneity and publication bias. The review has been registered in PROSPERO with protocol number CRD42020149475.

Results
We included 19 primary studies (with 6, 308 participants) in this meta-analysis. The pooled proportion of dietary adherence in the type 2 diabetes population was 41.05% (95% CI: 34.86–47.24, I2 = 93.1%). Educational level (Pooled Odds Ratio (POR): 3.29; 95%CI: 1.41–5.16; I2 = 91.1%), monthly income (POR: 2.50; 95%CI: 1.41–3.52; I2 = 0.0%), and who had dietary knowledge (POR: 2.19; 95%CI: 1.59–2.79; I2 = 0.0%) were statistically significant factors of dietary adherence.

Conclusion
The overall pooled proportion of dietary adherence among type 2 diabetes in Ethiopia was below half. Further works would be needed to improve dietary adherence in the type 2 diabetes population. So, factors that were identified might help to revise the plan set by the country, and further research might be required to health facility fidelity and dietary education according to diabetes recommended dietary guideline.