bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconciliação Terapêutica na Admissão de um Serviço de Medicina Interna: Estudo-Piloto
Authors: Costa e Silva Thaís , Dias Patrícia , Alves e Cunha Catarina , Feio José , Lavrador Marta , Oliveira Joelizy , Figueiredo Isabel Vitória , Rocha Marília João , Castel-Branco Margarida 
Published: March 2022

Introdução: A reconciliação terapêutica visa promover a segurança do doente por meio da redução de erros de medicação e eventos adversos decorrentes de discrepâncias de medicação na transição de cuidados. Foi nosso objetivo realizar um estudo-piloto de reconciliação terapêutica no momento da admissão hospitalar para, a partir dele, identificarmos os recursos necessários para a sua implementação na prática clínica.Material e Métodos: Estudo-piloto com 100 doentes admitidos num serviço de Medicina Interna entre outubro e dezembro de 2019, com mais de 18 anos e a tomar cronicamente pelo menos um medicamento. A melhor história farmacoterapêutica possível foi obtida sistematicamente, com posterior identificação, classificação e resolução das discrepâncias.Resultados: A amostra em estudo, em geral polimedicada e com múltiplas morbilidades, apresentou uma média de idades de 77,04 ± 13,74 anos, sendo 67,0% do sexo masculino. Foram identificadas 791 discrepâncias e as intencionais (95,7%) estavam documentadas em 50,9% das situações. As dificuldades encontradas relacionaram-se principalmente com o acesso e a qualidade da informação terapêutica e com a dificuldade de comunicação entre os diversos profissionais de saúde. Os principais recursos prioritários identificados relacionaram-se com as categorias de processo, ferramentas e pessoal.Conclusão: Os dados revelaram fragilidades nos registos clínicos disponíveis na interface dos cuidados primários/hospitalares. A otimização das fontes de dados, normalização e informatização do processo, atuação multidisciplinar e definição de grupos prioritários foram identificadas como oportunidades de otimização.
ANALISIS PENGARUH VARIABEL DER, NPM DAN ROE TERHADAP HARGA SAHAM PERUSAHAAN SEKTOR KEUANGAN
Authors: Rustaman La Ode Rahmat Putra 
Published: March 2022

Abstract: The main purpose of trading for the investors in capital market is a profit. This study aims to analyze the influence of fundamental factors such as debt to equity ratio, net profit margin, and return on equity on stock price. This study uses annual sample with the data from 2013-2018. Population of this research is 7 Factories, yet getting 7 factories after passing through the purposive sampling. This study uses analysis techniques of linear regression multiple which is a technique for knowing the entanglement of fundamental variables in the company to stock price in financial sector. The results of the study show that model of linear multiple regression equation is LN_Stock Price (Y) = 8,067 – 0,145 Debt to Equity Ratio + 4,759 Net Profit Margin + 1,961 Return On Equity and adjusted R2 value of 67,2 percent. Simultaneously these variable debt to equity ratio, net profit margin, and return on equity are significant to stock price, can be observed in value of probability is 0,000 < 0.05. Whereas, partially these variables debt to equity ratio and net profit margin have effects significantly on stock price as well as return on equity have effects insignificant on stock price all the same.
Keywords : Fundamental Factors, Debt to Equity (DER), Net Profit Margin (NPM), Return on Equity (ROE), Stock Prices.
Tumor necrosis factor-α and osterix expression after the transplantation of a hydroxyapatite scaffold from crab shell (Portunus pelagicus) in the post-extraction socket of Cavia cobaya
Authors: Salim Irvan , Kamadjaja Michael Josef Kridanto , Dahlan Agus 
Published: March 2022

Background: Socket preservation using bone graft is one way to minimise resorption and maximise the bone formation process. Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine that affects bone regenerating osteoblast activity, while osterix (Osx) is an osteoblast-specific transcription factor that activates gene receptors during pre-osteoblast differentiation. The hydroxyapatite (HA) scaffold from crab shells (Portunus pelagicus) has osteoconduction properties. Purpose: To analyse the decrease of TNF-α expression and the increase of Osx expression and the correlation between these two in the post-extraction socket after the transplantation of a crab shell HA scaffold. Methods: The lower left incisors of Cavia cobaya (n = 24) were extracted and divided into four groups: the first and second groups were control groups on Day 7 and Day 14 (K7 and K14), the third and fourth groups were treatment groups (P7 and P14). The statistical analysis used was a multivariate analysis of variance (MANOVA) with a significance level of 0.05. Results: A MANOVA test showed that the use of crab shell HA scaffolds led to a significant difference (p < 0.05) in TNF-α expression (p = 0.01) and Osx expression (p = 0.01). A Pearson correlation test result showed a strong inverse correlation between TNF-α and Osx expressions (p = 0.00 and r = -0.78). Conclusion: The transplantation of HA scaffolds from crab shells can decrease TNF-α expression but increase Osx expression in the post-extraction socket of C. cobayas. Furthermore, an inverse correlation was found between TNF-α and Osx.
The Relationship Between Religiosity and Morality of Junior High School Students
Authors: Karimah Inna Lailil , Dewanti Ririn 
Published: March 2022

Indonesia dikenal sebagai negara yang mempunyai adat istiadat yang menjunjung tinggi terutama pada moralitas atau etika dalam berperilaku. Seiring perkembangan zaman terutama pada zaman generasi milenial yang menjadikan menurunnya moral pada siswa. Terutama pada perkembangan anak dikalangan remaja saat ini. Banyak kemungkinn moralitas terhadap anak menjadi rendah. Rumusan masalah dalam penelitian ini adalah adakah hubungan antara religiusitas dengan moralitas remaja SMP Muhammadiyah 2 Taman.
Interpreting the nature of the Aulet and Adons diapirs from sedimentologic and stratigraphic analysis of flanking minibasin strata, Spanish Pyrenees, Catalunya, Spain
Authors: Gannaway Dalton C. Evelyn , Giles Katherine A. , Muñoz Josep Anton , Rowan Mark G. 
Published: March 2022

ABSTRACTThe Aulet and Adons diapirs are exposures of Triassic Keuper evaporites in the Ribagorça Basin in the south-central Pyrenees. The diapirs have been alternatively interpreted from mapped structural relationships as either passive salt diapirs or extensional salt rollers. Correspondingly, the associated diapir-flanking minibasins have been interpreted as either salt-withdrawal or extensional-rollover minibasins, respectively. New field mapping, stratigraphic sections, petrographic analysis, correlation diagrams, and drone photography characterize the depositional facies and stratal architecture of the flanking Sopeira, Sant Gervàs, and Faiada minibasins (upper Albian to lower Santonian synrift to postrift strata), which in turn, constrains the origin and evolution of each salt body and associated minibasins.Each minibasin displays unique facies patterns and stratal thicknesses that reflect depositional systems evolving in response to spatially and temporally variable extension, salt evacuation, and passive diapirism during the Pyrenean rift and postrift phases. The Sopeira minibasin developed in the late Albian with significant localized subsidence, but it remains inconclusive if the bounding Aulet diapir originated as a passive diapir or a salt roller. The Llastarri fault zone, previously interpreted as a salt weld, separates the Sopeira minibasin from the primarily extensional Sant Gervàs minibasin, and is reinterpreted here as a remnant salt ridge, as it lacks evidence for passive diapirism. The Sant Gervàs minibasin remained relatively uplifted until the middle to late Cenomanian, along with the Faiada minibasin. Evidence for passive diapirism in the Faiada minibasin, including diapir-derived detritus and composite halokinetic sequences, indicate salt evacuation into the bounding Adons passive diapir.Integration of detailed sedimentologic and stratigraphic analyses with interpretations of basin formation and structural development provides better resolution of the earlier phases of gravity-driven extension and loading-driven salt movement of the Aulet and Adons diapirs; these insights help constrain structural interpretations and reconstructions of Pyrenean shortening and megaflap development in the Ribagorça Basin. Sedimentological and stratigraphic evidence for or against passive diapirism need to be integrated into structural interpretations, especially when precursor salt structures are obscured by subsequent contraction. This well constrained basin framework demonstrates the effects of inherited extensional structures and passive diapirism on Pyrenean shortening and megaflap rotation.
Short-term efficacy and toxicity of total neoadjuvant chemotherapy in patients with resectable gastric cancer
Authors: Avgustinovich A. V. , Afanasyev S. G. , Dobrodeev A. Yu. , Volkov M. Yu. , Kostromitsky D. N. , Spirina L. V. , Cheremisina O. V. 
Published: March 2022

Background. Currently, perioperative chemotherapy is the standard treatment option for resectable gastric cancer (GC ) at stages higher than T1. Preoperative chemotherapy was shown do not adversely affect the course of the postoperative period in gastric cancer patients. However, approximately 60 % of radically operated patients complete adjuvant chemotherapy. In this regard, the problem arises of postponing all courses of chemotherapy for operable gastric cancer to the preoperative period.The purpose of the study was to analyze short-term efficacy and toxicity of total neoadjuvant chemotherapy with FLOT regimen in patients with resectable gastric cancer.Material and Methods. Since 2020, the Research Cancer Institute of Tomsk National Research Medical Center has been conducting a pilot study, which included 25 patients with resectable gastric cancer (T2–4N0–2M0) who received 8 cycles of neoadjuvant chemotherapy with FLOT regimen followed by radical surgery (gastrectomy or distal subtotal resection of the stomach).Results. Preoperative chemotherapy was completed in 25 (100 %) patients. Side effects that occurred during chemotherapy did not require cancellation or interruption of treatment and reduction in the initial dose of drugs. The most common adverse events were emetogenic reactions (92 %), peripheral neuropathy (60 %), and neutropenia (48 %). All patients had no greater than grade II toxicity, which was reversed with standard maintenance therapy. Radical surgeries were performed 6 weeks after completion of chemotherapy cycle 8. There were no significant postoperative complications (grade III or higher according to the Clavien–Dindo scale) and deaths. The histological examination revealed pathological response of TG R2–3 grade in 21 (84%) patients. Downstaging in both T and N categories was found in 13 (52%) patients.Conclusion. Eight cycles of total neoadjuvant chemotherapy for resectable gastric cancer demonstrates high efficacy, moderate toxicity, and do not adversely affect the course of the perioperative period.
Mutation in the kras gene as a predictor of the effectiveness of immunotherapy for non-small cell lung cancer
Authors: Laktionov K. K. , Kazakov A. M. , Sarantseva K. A. , Scherbo D. S. , Koval A. P. 
Published: March 2022

The purpose of the study: to conduct a systematic literature review on the effectiveness and feasibility of using information on the presence of KRAS gene mutations (in different codons), TP 53 (KP), ST K11/LKB1 (KL), and KEAP mutations and the association of KRAS m with PD -L1 status in patients with non-small cell lung cancer (NSCLC ) as a predictor of the effectiveness of immunotherapy with immune checkpoint inhibitors.Material and Methods. The review includes data from randomized clinical trials and meta-analyses on the predictive value of KRAS mutation status for response to immunotherapy in patients with NSCLC over the past 10 years.Results. The presence of KRAS mutations in NSCLC patients could be a predictive factor for their response to immunotherapy, as several studies have demonstrated benefit from immunotherapy in these patients. The combination of KRAS mutation with TP 53 (KP) co-mutation predicts a better response to immunotherapy, while a combination with ST K11/LKB1 (KL) and KEAP 1 predicts a worse response (reduced response rate and overall and disease-free survival). In PD -L1-positive patients, the presence of KRAS mutation is associated with a better prognosis after treatment with immunotherapy. Moreover, the presence of KRAS mutation is associated with a worse response to first-line and subsequent-line chemotherapy, thus indicating a more promising use of immunotherapy in these patients.Conclusion. Identification of TP 53 (KP), ST K11/LKB1 (KL), and KEAP 1 co-mutations and the presence of KRAS mutation in addition to determination PD -L expression enable selection of patients who will obtain the greatest benefit from immunotherapy. In addition, the ability to determine KRAS mutation and co-mutation status using a liquid biopsy (with acceptable specificity and sensitivity) makes it possible to use this method for determining sensitivity to immunotherapy when it is not possible to obtain tumor sample (to determine PD 1-L1 expression).
The use of biocompatible composite scaffolds in oncology
Authors: Kit O. I. , Maksimov A. Yu. , Novikova I. A. , Goncharova A. S. , Lukbanova E. A. , Sitkovskaya A. O. , Volovik V. G. , Chapek S. V. 
Published: March 2022

Modern tissue engineering approaches are aimed at developing scaffolds that contribute to the development of the whole variety of intercellular interactions that imitate those in a real object.The purpose of the study was to collect and summarize the data on the creation and use of three-dimensional cellular matrices.Material and Methods. A systematic literature search was conducted in the PubMed, Medline, Cyber Leninka and Elibrary databases. Out of the 315 articles searched, 38 were selected for this review.Results. A review of studies devoted to the development of three-dimensional composite structures (scaffolds) and their application in the field of cellular technologies was carried out. Methods for the manufacture of biocompatible structures using both natural biomaterials and synthetic ones, including various hydrogels and titanium alloys, were considered, and some physical and chemical characteristics were also discussed. The review discussed possible applications of 3D composite structures in oncology as one of the possible tools for expanding the fundamental understanding of the patterns of development of the malignant process, but also for use in the development of effective methods of treatment and the search for new drugs. The prospects for the use of scaffolds in the field of experimental oncology, namely in the creation of various types of tumor models, were outlined.Conclusion. Currently, three-dimensional culture systems are replacing two-dimensional models. Advances in this direction are associated with the creation and development of various variants of cell matrices that contribute to the solution of a number of applied problems in the field of creating three-dimensional tumor models in vitro and in vivo, therapy of malignant tumors and restorative medicine.
Impact of obesity on the oncological and surgical outcomes of thigh soft tissue sarcoma
Authors: Hamdy O. , Atallah Kh. , Ros M. H. , Metwally I. H. 
Published: March 2022

Background. Malignant soft tissue tumors are a heterogeneous group with variable prognosis and with a tendency to recurrence and distant spread, mainly to the lungs. Also, obesity is a known risk factor for many diseases and cancers and is currently a global problem. While the thigh is one of the main fat deposition areas, it is one of the commonest sites for the incidence of soft tissue sarcoma. We tried to illustrate the impact of obesity on the outcomes of thigh soft tissue sarcoma patients.Material and Methods. We retrospectively recruited data of extremity sarcomas treated at our hospital from January 2008 to January 2020. The epidemiological and clinical data of all the included patients was analyzed, then the surgical and oncological outcomes between obese and non-obese patients were compared (defining obesity as BMI more than 30). We hypothesized that fat deposition in the thigh in obese patients may delay the diagnosis of soft tissue sarcoma, lead to the discovery of the masses at a larger size and stage, and hence may affect the disease-free survival and the overall survival.Results. Obese patients had significantly larger size tumors (median: 14.7 vs 9.9 cm) and as such significantly higher T stage. Another significant finding was that the mean diameter of liposarcoma tumours was 15.1 cm, while that of non-liposarcomas was 11.3 cm (p-value=0.023). Also, although they did not have a higher prevalence of distant metastasis at initial diagnosis, their metastasis tends to be isolated in the lung. Postoperative complications occurred more frequently in obese patients in comparison to nonobese patients (p-value=0.025). Neither overall nor disease-free survivals were different among both groups, although obese patients tend to have shorter DFS.Conclusion. Obesity added complexity to the diagnosis and treatment of extremity sarcoma, but seems not to affect survival.
Pituitary Stalk Interruption Syndrome in a Newborn with Encephalopathy: A Case Report
Authors: Jose Mary J. , Leijser Lara M. , Pauranik Anvita , Amin Harish 
Published: March 2022

Background:
Pituitary Stalk Interruption Syndrome is a rare midline brain anomaly involving the pituitary gland that leads to a variable degree of pituitary
hypofunction with a classic neuroimaging finding of the ectopic posterior pituitary, thin or absent pituitary stalk, and anterior pituitary hypoplasia.

Case Presentation:
We present the case of a term newborn who developed encephalopathy and respiratory distress during the neonatal period and was later diagnosed
with Pituitary Stalk Interruption Syndrome.

Conclusion:
Genetic defects have been identified in 5% of cases, and at times there are associated extra pituitary malformations. In spite of being a welldescribed syndrome, a detailed description of its neonatal presentation and course is lacking in the literature.
Exosomal MiR-29a in Cardiomyocytes Induced by Angiotensin II Regulates
Cardiac Microvascular Endothelial Cell Proliferation, Migration and
Angiogenesis by Targeting VEGFA
Authors: Wang Yan , Shi Bei , Li Guangzhao , Qiu Zhimei , Li Chaofu , Zhao Ranzun , Zhang Yu , Shen Changyin , Liu Weiwei , Long Xianping , Zhuang Shaowei 
Published: March 2022

Background:
Exosomes released from cardiomyocytes (CMs) potentially play an important
role in angiogenesis through microRNA (miR) delivery. Studies have reported an important role for
miR-29a in regulating angiogenesis and pathological myocardial hypertrophy. However, whether CMderived
exosomal miR-29a is involved in regulating cardiac microvascular endothelial cell (CMEC)
homeostasis during myocardial hypertrophy has not been determined.

Methods:
Angiotensin II (Ang II) was used to induce CM hypertrophy, and ultracentrifugation was
then used to extract exosomes from a CM-conditioned medium. CMECs were cocultured with a conditioned
medium in the presence or absence of exosomes derived from CMs (Nor-exos) or exosomes
derived from angiotensin II-induced CMs (Ang II-exos). Moreover, a rescue experiment was performed
using CMs or CMECs infected with miR-29a mimics or inhibitors. Tube formation assays,
Transwell assays, and 5-ethynyl-20-deoxyuridine (EdU) assays were then performed to determine the
changes in CMECs treated with exosomes. The miR-29a expression was measured by qRT-PCR, and
Western blotting and flow cytometry assays were performed to evaluate the proliferation of CMECs.

Results:
The results showed that Ang II-induced exosomal miR-29a inhibited the angiogenic ability,
migratory function, and proliferation of CMECs. Subsequently, the downstream target gene of miR-
29a, namely, vascular endothelial growth factor (VEGFA), was detected by qRT-PCR and Western
blotting, and the results verified that miR-29a targeted the inhibition of the VEGFA expression to subsequently
inhibit the angiogenic ability of CMECs.

Conclusion:
Our results suggest that exosomes derived from Ang II-induced CMs are involved in regulating
CMCE proliferation, migration, and angiogenesis by targeting VEGFA through the transfer of
miR-29a to CMECs.
Edible Coatings to Enhance Shelf Life of Fruits and Vegetables:
A Mini-Review
Authors: Banu Azeez Thahira , Murugan Aswini , Lakshmi Duraikkannu Shanthana 
Published: March 2022

Abstract:
Recently, edible coatings or films have gained significant importance in fruit and vegetable
preservation. This review summarises edible coatings, the classification of coating materials,
formulation procedures, and the benefits of active edible coating. Studies reported that edible coating
or films from natural resources benefit the consumer as well as the environment. In general,
edible coatings or films are a combination of polysaccharides, proteins, lipids, and plasticizers,
used to enhance the functional properties and the general quality parameters of fruits and vegetables,
such as texture, colour, acidity, total soluble solids, thus preventing their browning and oxidation.
Casting (wet process) and extrusion (dry process) are two prominent methods used to fabricate
edible thin films. General techniques for applying edible coatings are dipping, spraying, coating,
panning, using a fluidized bed, and film wrapping. Active edible coatings or films are developed
with herbal extracts to improve the functional properties, i.e., antioxidant and antimicrobial.
Therefore, based on the literature review, future research exploration will focus on underutilized
edible natural resources, along with some natural edible plasticizers used to improve the postharvest
quality of fruits and vegetables without affecting their nutritional, organoleptic, and sensory
attributes. The primary objective of the present review was to summarize the different types of
edible coatings with an infusion of herbal extracts and their application on fruits and vegetables.