bluuebunny/crossref_metadata_2025_split huggingface dataset:
1-year radiological, functional and quality-of-life outcomes in patients with SARS-CoV-2 pneumonia - A prospective observational study
Authors: Marando Marco , Fusi-Schmidhauser Tanja , Tamburello Adriana , Grazioli Gauthier Lorenzo , Rigamonti Elia , Argentieri Gianluca , Puligheddu Carla , Pagnamenta Alberto , Valenti Antonio , Pons Marco , Gianella Pietro 
Published: March 2022

AbstractAll over the world, SARS-CoV-2 pneumonia is causing a significant short and medium-term morbidity and mortality, with reported persisting symptoms, radiological and lung alterations up to 6 months after symptoms onset. Nevertheless, the 1-year impact on affected patients is still poorly known. In this prospective observational study, 39 patients with SARS-CoV-2 pneumonia were recruited from a single COVID-19 hospital in Southern Switzerland. They underwent a 3-month and 1-year follow-ups. At 1 year, 38 patients underwent functional follow-up through lung function tests and six minutes walking test and submitted SF-12 and SGRQ questionnaires about health-related quality of life. At 1 year most of the patients showed a persistence of the radiological and functional abnormalities and a reduction of the health-related quality of life. Thirty patients (96.8%) still presented some residual abnormalities on CT scans (31 patients at 3 months), though with a general reduction of the lesional load in all lung lobes. Twenty patients (52.6%) had persisting lung function tests impairment, with an overall improvement of DLCO. As concerning the functional status, lowest SpO2 during 6MWT increased significantly. Finally, 19 patients (50%) reported a pathological St. George’s Respiratory Questionnaire, and respectively 12 (31.6%) and 11 (28.9%) patients a pathological Short Form Survey-12 in physical and mental components. At 1-year follow-up SARS-CoV-2 pneumonia survivors still present a substantial impairment in radiological and functional findings and in health-related quality of life, despite showing a progressive recovery.
Boosting the predictive performance with aqueous solubility dataset curation
Authors: Meng Jintao , Chen Peng , Wahib Mohamed , Yang Mingjun , Zheng Liangzhen , Wei Yanjie , Feng Shengzhong , Liu Wei 
Published: March 2022

AbstractIntrinsic solubility is a critical property in pharmaceutical industry that impacts in-vivo bioavailability of small molecule drugs. However, solubility prediction with Artificial Intelligence(AI) are facing insufficient data, poor data quality, and no unified measurements for AI and physics-based approaches. We collect 7 aqueous solubility datasets, and present a dataset curation workflow. Evaluating the curated data with two expanded deep learning methods, improved RMSE scores on all curated thermodynamic datasets are observed. We also compare expanded Chemprop enhanced with curated data and state-of-art physics-based approach using pearson and spearman correlation coefficients. A similar performance on pearson with 0.930 and spearman with 0.947 from expanded Chemprop is achieved. A steadily improved pearson and spearman values with increasing data points are also illustrated. Besides that, the computation advantage of AI models enables quick evaluation of a large set of molecules during the hit identification or lead optimization stages, which helps further decision making within the time cycle at drug discovery stage.
Mercury goes Solid at room temperature at nanoscale and a potential Hg waste storage
Authors: Kana N. , Morad R. , Akbari M. , Henini M. , Niemela J. , Hacque F. , Gibaud A. , Maaza M. 
Published: March 2022

AbstractWhile room temperature bulk mercury is liquid, it is solid in its nano-configuration (Ønano-Hg ≤ 2.5 nm). Conjugating the nano-scale size effect and the Laplace driven surface excess pressure, Hg nanoparticles of Ønano-Hg ≤ 2.4 nm embedded in a 2-D turbostratic Boron Nitride (BN) host matrix exhibited a net crystallization at room temperature via the experimentally observed (101) and (003) diffraction Bragg peaks of the solid Hg rhombohedral α-phase. The observed crystallization is correlated to a surface atomic ordering of 7 to 8 reticular atomic plans of the rhombohedral α-phase. Such a novelty of size effect on phase transition phenomena in Hg is conjugated to a potential Hg waste storage technology. Considering the vapor pressure of bulk Hg, Room Temperature (RT) Solid nano-Hg confinement could represent a potential green approach of Hg waste storage derived from modern halogen efficient light technology.
Coffee consumption and diabetic retinopathy in adults with diabetes mellitus
Authors: Lee Hak Jun , Park Ji In , Kwon Sung Ok , Hwang Daniel Duck-Jin 
Published: March 2022

AbstractWe aimed to evaluate the association between the prevalence of diabetic retinopathy (DR) and coffee consumption in a Korean population. This cross-sectional study was based on data from the 2008–2011 Korean National Health and Nutrition Survey. Among 37,753 survey participants, the data of 1350 subjects with type 2 diabetes who underwent DR examination were analyzed. DR was graded using the modified Airlie House classification system. Coffee consumption data were obtained through food frequency questionnaires and categorized into four groups: almost none, < 1 cup/day, 1 cup/day, and ≥ 2 cups/day. The relationship between DR and coffee consumption was evaluated using multivariable logistic regression models adjusted for age, sex, education, occupation, income, smoking, alcohol intake, body mass index, physical activity, hypertension, dyslipidemia, diabetes duration, and glycated hemoglobin. The prevalence of DR was 20.0%. Non-proliferative DR was observed in 87.8% of all DR patients, and proliferative DR in 12.2%. The prevalence of DR and vision-threatening DR showed a significantly decreasing tendency according to daily coffee consumption (P for trend 0.025 and 0.005, respectively) after adjustment for possible confounders. This tendency was more prominent in those aged < 65 years (P for trend 0.005 and 0.003, respectively). Our findings suggest coffee consumption might be associated with DR reduction especially in Koreans with diabetes mellitus aged < 65 years.
Creating hot spots within air for better sensitivity through design of oblique-wire-bundle metamaterial perfect absorbers
Authors: Wu Xin-Xian , Lu Cheng-Yu , Huang Tsung-Yu 
Published: March 2022

AbstractBetter sensitivity of a biosensor could boost up the detection limit of analytes, thus a must in the fields of bio-sensing and bio-detection. To further enhance the sensitivity of a biosensor, in this work, we design an oblique-flat-sheet metamaterial perfect absorber (MPA) to concentrate the hot spots within air between the oblique flat sheet and the continuous ground metal, thus enabling fully interaction between analytes and hot spots. The corresponding field distributions in simulation corroborated our assumption and its sensitivity could be up to 1049 nm/RIU. Then, we fabricated the sample by e-beam lithography process for a seed layer and simply tilting the sample during deposition to obtain oblique flat sheets. When considering the stochastic nature of the deposited multiple oblique flat sheets, we modified the metallic upper resonator of the MPA from the single oblique-flat-sheet into randomly distributed oblique-wire-bundle (OWB) and in simulation, its sensitivity is boosted up to 3319 nm/RIU. In experiments, the measured sensitivity is 1329 nm/RIU under different concentrations of glucose solutions that is four times larger than the 330 nm/RIU of the planar MPA. The higher sensitivity was attributed to that the OWB MPA could provide hot spots within air not only between OWB and grounded metal but also among wires. Moreover, the OWB could also trap and concentrate the analytes locally.
A systematic review and meta-analysis of social cognition training success across the healthy lifespan
Authors: Roheger Mandy , Hranovska Kseniya , Martin Andrew K. , Meinzer Marcus 
Published: March 2022

AbstractSocio-cognitive abilities and challenges change across the healthy lifespan and are essential for successful human interaction. Identifying effective socio-cognitive training approaches for healthy individuals may prevent development of mental or physical disease and reduced quality of life. A systematic search was conducted in MEDLINE Ovid, Web of Science Core Collection, CENTRAL, and PsycInfo databases. Studies that investigated different socio-cognitive trainings for healthy individuals across the human lifespan assessing effects on theory of mind, emotion recognition, perspective taking, and social decision making were included. A random-effects pairwise meta-analysis was conducted. Risk-of-Bias was assessed using the Cochrane Risk-of-Bias-2-Tool. Twenty-three intervention studies with N = 1835 participants were included in the systematic review; twelve randomized controlled trials in the meta-analysis (N = 875). Socio-cognitive trainings differed regarding duration and content in different age groups, with theory of mind being the domain most frequently trained. Results of the meta-analysis showed that trainings were highly effective for improving theory of mind in children aged 3–5 years (SMD = 2.51 (95%CI: 0.48–4.53)), children aged 7–9 years (SMD = 2.71 (95%CI: − 0.28 to 5.71)), and older adults (SMD = 5.90 (95%CI: 2.77–9.02). Theory of mind training was highly effective in all investigated age-groups for improving theory of mind, yet, more research on transfer effects to other socio-cognitive processes and further investigation of training effects in other socio-cognitive domains (e.g., emotion recognition, visual perspective taking, social decision making) is needed. Identified characteristics of successful socio-cognitive trainings in different age groups may help designing future training studies for other populations.Registration:www.crd.york.ac.uk/PROSPERO/ (ID: CRD42020193297).
The lasting effects of resistance and endurance exercise interventions on breast cancer patient mental wellbeing and physical fitness
Authors: Mok Jonathon , Brown Marie-Juliet , Akam Elizabeth C. , Morris Mhairi A. 
Published: March 2022

AbstractBreast cancer is a persisting global burden for health services with cases and deaths projected to rise in future years. Surgery complemented by adjuvant therapy is commonly used to treat breast cancer, however comes with detrimental side effects to physical fitness and mental wellbeing. The aim of this systematic review and meta-analysis is to determine whether resistance and endurance interventions performed during adjuvant treatment can lastingly ameliorate these side effects. A systematic literature search was performed in various electronic databases. Papers were assessed for bias and grouped based on intervention design. RStudio was used to perform the meta-analyses for each group using the ‘meta’ package. Publication bias and power analyses were also conducted. These methods conform to PRISMA guidelines. Combined resistance and endurance interventions elicited significant long-lasting improvements in global fatigue and were beneficial to the remaining side effects. Individually, resistance and endurance interventions non-significantly improved these side effects. Resistance interventions elicited higher benefits overall. Exercise interventions have lasting clinical benefits in ameliorating adjuvant therapy side effects, which negatively impact physical fitness and mental wellbeing. These interventions are of clinical value to enhance adherence rates and avoid comorbidities such as sarcopenia, thus improving disease prognosis.
Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids
Authors: Buenafe Abigail C. , Dorrell Craig , Reddy Ashok P. , Klimek John , Marks Daniel L. 
Published: March 2022

AbstractExtracellular vesicles (EVs) are produced and released by both healthy and malignant cells and bear markers indicative of ongoing biological processes. In the present study we utilized high resolution flow cytometry to detect EVs in the plasma of patients with pancreatic ductal adenocarcinoma (PDAC) and in the supernatants of PDAC and healthy control (HC) pancreatic organoid cultures. Using ultrafiltration and size exclusion chromatography, PDAC and HC pancreatic organoid EVs were isolated for mass spectrometry analysis. Proteomic and functional protein network analysis showed a striking distinction in that EV proteins profiled in pancreatic cancer organoids were involved in vesicular transport and tumorigenesis while EV proteins in healthy organoids were involved in cellular homeostasis. Thus, the most abundant proteins identified in either case represented non-overlapping cellular programs. Tumor-promoting candidates LAMA5, SDCBP and TENA were consistently upregulated in PDAC EVs. Validation of specific markers for PDAC EVs versus healthy pancreatic EVs will provide the biomarkers and enhanced sensitivity necessary to monitor early disease or disease progression, with or without treatment. Moreover, disease-associated changes in EV protein profiles provide an opportunity to investigate alterations in cellular programming with disease progression.
Coseismic fault slip inversion of the 2013 Lushan Ms 7.0 earthquake based on the triangular dislocation model
Authors: Duan HuRong , Chen JiaYing , Zhang ShuangCheng , Wu XiaoLong , Chu ZiMing 
Published: March 2022

AbstractThe 2013 Lushan Ms 7.0 earthquake occurred on the Longmenshan thrust tectonic zone, a typical blind reverse-fault type earthquake that caused the death of nearly 200 people. The investigation of the fault geometry and fault slip distribution of this earthquake is important for understanding the seismogenic tectonic type and seismic activity mechanism of the Longmenshan Fault Zone. In this paper, for the fault geometry of the Ms 7.0 earthquake in Lushan, the geometric parameters of the planar fault are inverted based on the rectangular dislocation model using GPS coseismic displacement data, and on this basis, a curved fault steeply-dipping on top and gently-dipping at depth is constructed by combining the aftershock distribution. The GPS and leveling data are used to invert the slip distribution of the curved fault for the Lushan Ms 7.0 earthquake. The results show that the fault is dominated by reverse slip with a small amount of sinistral rotation, and there is a peak slip zone with a maximum slip of 0.98 m, which corresponds to a depth of ~ 13.50 km, and the energy released is 1.05 × 1019 N/m with a moment magnitude of Mw 6.63. Compared with the planar rectangular dislocation model, the curved fault model constructed by using triangular dislocation elements can not only better approximate the fault slip, but also better explain the observed surface displacement, and the root mean square error of the GPS and leveling data fitting is reduced by 1.3 mm and 1.9 mm, respectively. Both the maximum slip and moment magnitude of the fault based on the inversion of the curved structure are slightly larger than the results based on the planar structure.
Two-dimensional CNN-based distinction of human emotions from EEG channels selected by multi-objective evolutionary algorithm
Authors: Moctezuma Luis Alfredo , Abe Takashi , Molinas Marta 
Published: March 2022

AbstractIn this study we explore how different levels of emotional intensity (Arousal) and pleasantness (Valence) are reflected in electroencephalographic (EEG) signals. We performed the experiments on EEG data of 32 subjects from the DEAP public dataset, where the subjects were stimulated using 60-s videos to elicitate different levels of Arousal/Valence and then self-reported the rating from 1 to 9 using the self-assessment Manikin (SAM). The EEG data was pre-processed and used as input to a convolutional neural network (CNN). First, the 32 EEG channels were used to compute the maximum accuracy level obtainable for each subject as well as for creating a single model using data from all the subjects. The experiment was repeated using one channel at a time, to see if specific channels contain more information to discriminate between low vs high arousal/valence. The results indicate than using one channel the accuracy is lower compared to using all the 32 channels. An optimization process for EEG channel selection is then designed with the Non-dominated Sorting Genetic Algorithm II (NSGA-II) with the objective to obtain optimal channel combinations with high accuracy recognition. The genetic algorithm evaluates all possible combinations using a chromosome representation for all the 32 channels, and the EEG data from each chromosome in the different populations are tested iteratively solving two unconstrained objectives; to maximize classification accuracy and to reduce the number of required EEG channels for the classification process. Best combinations obtained from a Pareto-front suggests that as few as 8–10 channels can fulfill this condition and provide the basis for a lighter design of EEG systems for emotion recognition. In the best case, the results show accuracies of up to 1.00 forlow vs high arousalusing eight EEG channels, and 1.00 forlow vs high valenceusing only two EEG channels. These results are encouraging for research and healthcare applications that will require automatic emotion recognition with wearable EEG.
Spontaneous patterning method utilizing transformation of UV-curable emulsion
Authors: Inaba Yoshimi , Asama Hideo 
Published: March 2022

AbstractA self-organizing structure is important for imparting functions and simplifying the manufacturing process. The development of spontaneous structures with a roll-to-roll process capability is a challenging task. We propose a novel patterning method utilizing the destruction of the emulsion structure. An oil-in-water (O/W) UV-curable emulsion liquid film was partially exposed to UV, resulting in aggregation and immobilization of the emulsion in the medium. Emulsion droplets in the unexposed area are coalesced by removing water. Coalesced emulsion droplets expand and spontaneously permeate into the pores formed in the aggregated structure of UV-cured emulsion particles, causing an uneven structure. An uneven pattern can be formed by direct UV exposure of the liquid film and the subsequent drying process without requiring a development process.
The cognitive and psychiatric subacute impairment in severe Covid-19
Authors: Serrano-Castro Pedro J. , Garzón-Maldonado Francisco J. , Casado-Naranjo Ignacio , Ollero-Ortiz Angela , Mínguez-Castellanos Adolfo , Iglesias-Espinosa Mar , Baena-Palomino Pablo , Sánchez-Sanchez Violeta , Sánchez-Pérez Rosa María , Rubi-Callejon José , Estévez-María José Carlos , Galeano-Bilbao Benito , Romero-Imbroda Jesús , Sobrino Beatriz , Arrabal-Gomez Carlos , Oliver-Martos Begoña , Muñoz-Becerra Luis , Requena Nerea , González Álvarez de Sotomayor María del Mar , Estivill-Torrus Guillermo , Suarez Juan , Ciano-Petersen Nicolas Lundahl , Pons-Pons Gracia , Reyes-Bueno Jose Antonio , Cabezudo-Garcia Pablo , Aguilar-Castillo Maria José , De la Cruz Cosme Carlos , Duque-Holguera María , Cuartero-Rodriguez Eva , Vilches-Carrillo Rosa María , Carrera-Muñoz Ismael , Carnero-Pardo Cristóbal , Ramirez-Garcia Teresa , Oropesa Juan Manuel , Dominguez-Mayoral Ana , Pelaez-Viñas Nazaret , Valiente Lucia , de Fonseca Fernando Rodríguez 
Published: March 2022

AbstractNeurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases.
A specific relationship between musical sophistication and auditory working memory
Authors: Lad Meher , Billig Alexander J. , Kumar Sukhbinder , Griffiths Timothy D. 
Published: March 2022

AbstractPrevious studies have found conflicting results between individual measures related to music and fundamental aspects of auditory perception and cognition. The results have been difficult to compare because of different musical measures being used and lack of uniformity in the auditory perceptual and cognitive measures. In this study we used a general construct of musicianship, musical sophistication, that can be applied to populations with widely different backgrounds. We investigated the relationship between musical sophistication and measures of perception and working memory for sound by using a task suitable to measure both. We related scores from the Goldsmiths Musical Sophistication Index to performance on tests of perception and working memory for two acoustic features—frequency and amplitude modulation. The data show that musical sophistication scores are best related to working memory for frequency in an analysis that accounts for age and non-verbal intelligence. Musical sophistication was not significantly associated with working memory for amplitude modulation rate or with the perception of either acoustic feature. The work supports a specific association between musical sophistication and working memory for sound frequency.
Comparison of peripherally inserted central catheters (PICCs) versus totally implantable venous-access ports in pediatric oncology patients, a single center study
Authors: Zhang Hong , Li Yumei , Zhu Nannan , Li Yanfang , Fu Jinqiu , Liu Jing 
Published: March 2022

AbstractTo compare the efficacy of peripherally inserted central catheters (PICCs) and totally implantable venous-access ports (TIVAPs) for chemotherapy of pediatric patients with malignant tumors. A total of 96 children with malignant tumors who received catheterization of PICCs or TIVAPs for chemotherapy from May 2020 to May 2021 in Department of Pediatric Oncology of Qilu Hospital of Shandong University were selected. Then, the pathological features of disease, the age of children, the indwelling time, the incidence of postoperative complications, and the satisfaction degree were compared between the two groups. The age of children in the TIVAP group was younger than that in the PICC group (P < 0.05). The indwelling time in the TIVAP group was 7.2 ± 2.757 months,which was significantly longer than 5.65 ± 2.058 months in the PICC group (P < 0.05). The incidence of postoperative complications in the TIVAP group without systemic or local infection was markedly lower than that in the PICC group (P < 0.05). The satisfaction degree of patients in the TIVAP group without unsatisfied was markedly higher than that in the PICC group (P < 0.05). TIVAPs may be the first choice for chemotherapy of children with malignant tumors.