bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photodynamic and Its Concomitant Ion‐Interference Synergistic Therapies Based on Functional Hierarchically Mesoporous MOFs
Authors: He Miao , Li Ke , Yang Jian , Wang Qinghua , Gu Jinlou 
Published: August 2022

AbstractAlthough ion‐interference therapy (IIT) has become an intriguing option for cancer treatment, the generation of interference ions on‐demand remains a challenge. Herein, a nanoplatform based on hierarchically mesoporous metal–organic frameworks (HMMOFs) is adopted to integrate black phosphorus quantum dots (BPQDs) and meso‐tetra(4‐carboxyphenyl) porphine (TCPP) to realize controllable phosphate anions (PAs) production in a specific cancerous region for IIT. The uniform large mesopores of HMMOFs could guarantee the selective screening and immobilization of ultra‐small and monodispersed BPQDs. The TCPP in microporous domains of HMMOFs could effectively produce 1O2, which not only serves as photosensitizer for photodynamic therapy (PDT), but also switches on the release of PAs from BPQDs in the adjacent mesoporous domains to trigger the concomitant synergetic IIT. The elaborated nanoplatform (BP@HMUiO‐66‐TCPP) presents good biocompatibility, biodegradability as well as enhanced synergetic therapeutic effects. In murine models treated with BP@HMUiO‐66‐TCPP, the tumor inhibition rate is as high as ≈98.24% as compared to that of the control group after 14 days treatment. Moreover, the tumor volumes in the synergetic group are only 19.6% of those in the PDT alone treated group. Such a concept of exogenous photo‐controlled synergistic therapeutics might be extended to a broad range of IIT for an improved antitumor efficacy.
Private record linkage with linkage maps
Authors: Patel Shreya , Dewri Rinku 
Published: August 2022

AbstractPrivate record linkage is an actively pursued research area to facilitate the linkage of database records under the constraints of regulations that do not allow linkage agents to learn sensitive identities of record owners. Recent works have shown that linkage using commutative ciphers, which were discarded earlier for efficiency concerns, can be made feasible by leveraging precomputations, data parallelism, and probabilistic key reuse approaches. In this work, we propose further optimizations that can be performed to improve the runtime efficiency of such an approach. We transition from modular exponentiation ciphers to elliptic curve operations to improve precomputation time, eliminate memory intensive comparisons of encrypted values, and introduce data structures to detect negative comparisons. We benchmark the proposed approach using real world demographics data, and provide an extensive study of the parametric aspects of the approach. We also supplement our execution time results with an assessment of the residual privacy risk left by the approach. The approach can perform a linkage of two datasets with 105 records each in 20 minutes in a commodity laptop. This is achieved by eliminating the need to compare more than 70% of the record pairs. By design, the linkage accuracy is also retained at the same level as a nonprivate record linkage procedure.
Performance and modeling studies of rotating biological contactor for treatment of vegetable oil wastewater
Authors: Radha Kuravappullam Vedaiyan 
Published: August 2022

AbstractThis study focuses on a lab‐scale rotating biological contactor (RBC) treating vegetable oil wastewater with high BOD and COD. The fabricated RBC was checked for efficiency in degrading polluted wastewater under different operating conditions. The maximum removal efficiencies for BOD and COD were 95.75% and 89%, respectively. This high removal percentage was obtained with 30% submergence of 10 discs rotating at 8 rpm. For the first time, bio‐kinetic models were applied to the experimental results for vegetable oil wastewater. The best fit was obtained with the modified Stover‐Kincannon and Grau model. The saturation constant (Ks) values were 1.872 and 3.024 g/L/d for BOD and COD, respectively, for the modified Stover‐Kincannon and Grau model. For the Grau second‐order model, the saturation constant was 1.416 and 3.744 g/L/d for BOD and COD, respectively. The predicted effluent BOD and COD values of the modified Stover–Kincannon model fitted almost exactly with the experimental values. This clearly predicts that this model can be best used to predict effluent BOD and COD concentration in a Rotating Biological contactor treating vegetable oil wastewater. The kinetic parameters determined in this study can be used to improve the design and operation of continuous mode RBC systems.
The anti‐Trypanosoma activities of medicinal plants: A systematic review of the literature
Authors: Nekoei Shahin , Khamesipour Faham , Habtemariam Solomon , de Souza Wanderley , Mohammadi Pour Pardis , Hosseini Seyed Reza 
Published: August 2022

AbstractBackgroundThe existing drug treatments for trypanosomiases are limited and suffer from shortcomings due to their toxicity and the emergence of resistant parasites. Developing anti‐trypanosomal compounds based on natural products is a promising way of fighting trypanosomiases.ObjectivesThis study aims to identify through scientific review a large variety of medicinal plants (anti‐trypanosomal) used worldwide and scientifically shown to display anti‐trypanosomal effects.MethodsTo collect data, the anti‐trypanosomal activities of Africa, Asia, the Middle East, South America, North America, Europe and Oceania medicinal plants have been checked by considering the published paper.ResultsBased on collected data, 77 natural molecules were reported in the literature. Of which 59 were from the African region, 11 from Asia, 3 from Europe and 4 from Latin America. These active components belong to alkaloids, triterpenoids, lactone, quinoids, flavonoids, iridoids, lignans, steroids, lipids, oxygenated heterocycles, benzenoids, proteins, coumarins, phenylpropanoids and peptides. We also specified the prosperous plants with unique anti‐trypanosomal activities.ConclusionsHowever, there is a need for further studies on the ability of the isolated compounds to ameliorate the trypanosome‐induced pathological alterations and also the elucidation of their modes of actions and activities against other trypanosome species.
Blood–brain barrier permeability to enrofloxacin in Pengze crucian carp (Carassius auratus var. Pengze)
Authors: Zhang Fan , Wang Runping , Huang Jianzhen , Zhang Haixin , Wang Long , Zhong Zhiwei , Ruan Jiming , Liu Huazhong 
Published: August 2022

AbstractBackgroundEnrofloxacin (ENR) is a kind of quinolone antibiotic that is most widely used antimicrobials in veterinary practice, and possesses both a broad spectrum antimicrobial activity against a range of bacteria and adverse effects towards plants and animals.ObjectivesThis study was conducted to explore the permeability of blood–brain barrier (BBB) to ENR and brain injury based on crucian carp orally administrated with high dose of ENR.MethodsJuvenile Pengze crucian carp were treated with half lethal dose (LD50) or safe dose (SD50) of ENR. BBB permeability was determined by evaluating ENR contents detected by HPLC and evens blue contents estimated by confocal laser scanning microscope. Brain damage was evaluated by measuring protein and mRNA contents of related molecules with western blotting and qPCR.ResultsData indicated that ENR destroyed BBB structure of crucian carp and enhanced permeability of the biological barrier, resulting in more ENR crossed BBB and induced brain damage of crucian carp.ConclusionsThis data indicated that ENR can induce brain damage of crucian carp through destroying BBB structure and enhancing permeability.
Attributes of funding flows and quality of maternal health services in a mixed provider payment system: A cross‐sectional survey of 108 healthcare providers in Indonesia
Authors: Stein Dorit Talia , Rakhmadi Mukhammad F. , Dutta Arin , Ugaz Jorge I. 
Published: August 2022

AbstractStrategic purchasing of health services requires developing a coherent set of incentives across financing sources. In many countries, including Indonesia, healthcare providers engage with multiple financing sources. It is not well known how multiple funding flows in these mixed provider payment systems may interact at the facility level to influence provider behavior, quality of care, and ultimately health outcomes. Our study explored the association between facility capacity to provide high‐quality maternal and newborn care at delivery and various attributes of facility funding, including funding flexibility, sufficiency of funds to cover direct costs, predictability of funds in timing and amount, and facility autonomy to make management decisions (decision space). We used survey data collected from primary and secondary maternal healthcare providers (n = 108) across eight provinces in Indonesia. We constructed a technical quality index that measures facility capacity to provide high‐quality delivery care and several financing measures that summarize provider perceptions of flexibility, sufficiency, predictability of fund flows, and provider decision space. We found a statistically significant association between the decision space index score and the technical quality index score among hospitals and public primary care providers. One additional point on the decision space index was associated with an additional 0.15 (p = 0.021; 95% confidence interval: 0.024–0.275) on the quality index score after controlling for provider characteristics and geographic location. Our findings suggest that increasing facility autonomy to make management decisions may be one avenue for improving facility capacity to provide high‐quality care in systems where providers deal with multiple fund flows with varying attributes. Design of strategic purchasing reforms must consider the full context in which providers operate to streamline incentives and ensure providers have the capacity to respond to those incentives appropriately.
[Ag(μ‐en)][ReO4]: An Intermediate during Preparation of the Ethylene Epoxidation Catalyst
Authors: Badea Désirée , Karpov Andrey , Jansen Martin , Bruns Jörn 
Published: August 2022

AbstractPreparation of a catalyst for the ethylene oxide production requires impregnation of a porous corundum support with an aqueous silver ethylene diamine oxalate complex solution, to which among others NH4[ReO4] is added. Here we report on [Ag(μ‐en)][ReO4] that precipitates from such a mixture. Single crystal structure analysis has revealed a striking similarity of the [Ag(μ‐en)]+ entity with the same complex cation encountered in[Ag(μ‐en)]2(C2O4)×2H2O. Silver is coordinated end‐on to the nitrogen atoms of the en ligands. The [ReO4]− anions are not bonded to the silver cations, but instead involved in N−H⋅⋅⋅O hydrogen bonds to the ethylene diamine molecules. The first step of thermal degradation occurs at approximately the same temperature for both, the main component precipitate [Ag(μ‐en)]2(C2O4)×2H2O and [Ag(μ‐en)][ReO4], warranting proximity of the rhenium promoter and the elemental silver deposit. At 300 °C, the temperature at which the catalyst for EO synthesis is commonly calcined, the decomposition product of plain [Ag(μ‐en)][ReO4] under synthetic air is Ag[ReO4], in full analogy to industrial manufacturing process for selected Re‐promoted EO catalyst formulations.
Impact of female contraception for population management on behavior and social interactions in a captive troop of Guinea baboons (Papio papio)
Authors: Taberer Tabitha R. , Mead Jasmine , Hartley Matthew , Harvey Naomi D. 
Published: August 2022

AbstractAs part of a population management strategy for a troop of Guinea baboons (Papio papio) at Yorkshire Wildlife Park, adult females were given a Suprelorin contraceptive implant. There was no information on the effect of contraception on behavior in this species, so behavioral data were collected before and after implant placement to determine any impact on the troops’ welfare. Social interactions, affiliative, agonistic, and self‐directed displacement behaviors (SDBs) in all adults were monitored via focal sampling. Preimplant data were collected in August/September 2019 before Suprelorin placement on November 2019, and postimplant data were collected in August/September 2020, allowing for comparison while controlling for seasonal differences in behavior. We found a significant reduction of SDBs after intervention, suggesting that contraception has a positive impact on group welfare, as SDBs are key behavioral indicators of stress and anxiety in nonhuman primates. Additionally, the rate of substate change per hour (i.e., the number of times the baboon changed their behavior), duration of sentry behavior, and the frequency of agonistic bouts were significantly lower postimplant, further suggesting improvements in welfare. There were also no significant decreases in the duration of positive social interactions, such as allogrooming and play. The results show that Suprelorin did not have a detrimental impact on the behavior of adults in the troop and may have even improved welfare. The use of Suprelorin in females could be considered as an effective population management strategy for primates existing in similar social systems.
Secular Time: Origin Story and Operationalization
Authors: Fisher-Høyrem Stefan 
Published: August 2022

AbstractThe chapter begins by presenting a new origin story of secular time. This concept was developed in recognizable form in thirteenth-century scholastic angelological debates, where the terms saeculum or aevum came to denote an abstract and isochronic time independent of motion. Angels were cast as immutable mobiles, immaterial creatures moving through the created world without deterioration, and secular time was conceptualized in response to this imagined possibility of creatures ‘moving while at rest’. The second section of the chapter shows how Actor-Network Theory offers useful insights into how socio-technological networks centred on creating and sustaining immutable mobiles—to the degree that they are successful in this—thereby also mediate secular time. This provides the basis for the case studies presented in the following three chapters.
Selbstbezeichnungen und ihre Bedeutungsnuancen
Authors: Becci Irene , Dandarova Robert Zhargalma 
Published: August 2022

ZusammenfassungVor dem Hintergrund der aktuellen Veränderungen der globalen sozio-religiösen Landschaften, die die Bedeutungen und kulturellen Aneignungen des Begriffs der Spiritualität verändern (Fedele und Knibbe 2013), wird in diesem Artikel näher untersucht, welche Unterschiede und Gemeinsamkeiten zwischen «spirituell» und «religiös» tatsächlich auszumachen sind. Mit der Analyse der Antworten von Personen, die in der Querschnittsbefragung MOSAiCH (2009 und 2018) zu den Werten und Einstellungen der Schweizer Bevölkerung zu einer Vielzahl von gesellschaftlichen Themen angeben, ob sie sich zu einer Religion bekennen oder nicht, oder ob sie sich als eine spirituelle Person betrachten oder nicht, folgen die Autorinnen dem Anspruch, eine soziostrukturelle Perspektive in die Religionswissenschaft zu bringen. Die kontextuelle soziale Dimension der Unterscheidungen zwischen diesen Identifikationen wird in struktureller Hinsicht hinterfragt, wobei insbesondere ein demografisches Profil der Gruppen erstellt wird. Die Autorinnen kommen zu dem Schluss, dass es notwendig ist, die Verwendung der aktuellen Kategorie «Spiritualität» in ihrem tatsächlichen sozialen und sprachlichen Kontext zu verorten und einzubetten.
The Trails and Territories of Adversity
Authors: Chevez Agustin 
Published: August 2022

AbstractI find Signpost 4 particularly intriguing. It tells us that adversities are worth keeping, even introduced, in the workplace to promote innovation. This signpost points in the opposite direction from the way in which design deals with adversity and David summarised this well: "this better version of the world has a lot to do with removing the bad, including adversity." That is why even if adversity is as good at delivering wisdom and innovation, design might be as hardwired to avoid it as the rest of us.
No Pain, No Gain
Authors: Chevez Agustin 
Published: August 2022

AbstractHaving a rule or prescribed manner in which distance should be covered is a common feature among most pilgrimages. Rarely are these intended to improve the comfort or welfare of the pilgrim, in most cases, it’s quite the opposite. For example, a Tibetan pilgrimage requires pilgrims to perform body-length prostrations along a rocky path for 50 km – suffering is a necessary part of the journey [9]. Whereas most of us hope to be saved from pain, others hope to be saved through pain [10].
My Two Rules
Authors: Chevez Agustin 
Published: August 2022

AbstractA pilgrimage needs boundaries, and I defined mine before I took my first step. Rule One was simple and straightforward, I had to be alone. I walked by myself and avoided contact with family or friends so that I could evolve my ideas without the influence of others. For safety reasons, I sent daily text messages to let people know where I was and that I was ok, but that was all I allowed myself.
The Idea
Authors: Chevez Agustin 
Published: August 2022

AbstractAs important as it was to be prepared, I still needed to work on the reason why I needed to be prepared. I needed an idea to incubate. Choosing the right idea was critical, I didn’t want to finish the walk only to discover that my mind had figuratively walked in the wrong direction, even if my sore legs made it quite clear they had taken me to Sydney.
Explicit Solutions to the 3D Incompressible Euler Equations in Lagrangian Formulation
Authors: Saleva Tomi , Tuomela Jukka 
Published: August 2022

AbstractWe introduce many families of explicit solutions to the three dimensional incompressible Euler equations for nonviscous fluid flows using the Lagrangian framework. Almost no exact Lagrangian solutions exist in the literature prior to this study. We search for solutions where the time component and the spatial component are separated, applying the same ideas we used previously in the two dimensional case. We show a general method to derive separate constraint equations for the spatial component and the time component. Using this provides us with a plenty of solution sets exhibiting several different types of fluid behaviour, but since they are computationally heavy to analyze, we have to restrict deeper analysis to the most interesting cases only. It is also possible and perhaps even probable that there exist more solutions of the separation of variables type beyond what we have found.
DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment
Authors: Bernhardt Denise , König Laila , Grosu Anca-L. , Rieken Stefan , Krieg Sandro M. , Wick Wolfgang , Wiestler Benedikt , Schmidt-Graf Friederike , Sahm Felix , Gempt Jens , Meyer Bernhard , Krause Bernd J. , Petersen Cordula , Fietkau Rainer , Thomas Michael , Giordano Frank , Wittig-Sauerwein Andrea , Debus Jürgen , Tabatabai Ghazaleh , Hau Peter , Steinbach Joachim , Combs Stephanie E. ,   Expert Panel of the German Society of Radiation Oncology (DEGRO)
Published: August 2022

Abstract
Purpose
The Working Group for Neurooncology of the German Society for Radiation Oncology (DEGRO; AG NRO) in cooperation with members of the Neurooncological Working Group of the German Cancer Society (DKG-NOA) aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).

Methods
Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN, including bevacizumab, in clinical routine.

Conclusion
Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neurooncologist. If the diagnosis of blood–brain barrier disruptions (BBD) or RN is likely, treatment should be initiated depending on the symptoms, location, and dynamic of the lesion. Multiple treatment options are available (such as observation, surgery, steroids, and bevacizumab) and the optimal approach should be discussed in an interdisciplinary setting. In this practice guideline, we offer detailed treatment strategies for various scenarios.
DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis
Authors: Bernhardt Denise , König Laila , Grosu Anca , Wiestler Benedikt , Rieken Stefan , Wick Wolfgang , Gempt Jens , Krieg Sandro M. , Schmidt-Graf Friederike , Sahm Felix , Meyer Bernhard , Krause Bernd J. , Petersen Cordula , Fietkau Rainer , Thomas Michael , Giordano Frank , Wittig-Sauerwein Andrea , Debus Jürgen , Tabatabai Ghazaleh , Hau Peter , Steinbach Joachim , Combs Stephanie E. ,   Expert Panel of the German Society of Radiation Oncology (DEGRO)
Published: August 2022

Abstract
Purpose
The Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).

Methods
Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine.

Conclusion
Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a detailed nomenclature of treatment-related changes and a multistep approach for their diagnosis.