bluuebunny/crossref_metadata_2025_split huggingface dataset:
MULHERES GORDAS NA PANDEMIA: gordofobia, (re)existências e ativismo gordo
Authors: Raposo Leila Cunha , Jimenez Jimenez Maria Luisa 
Published: August 2022

Resumo: Discutimos as inter-relações entre gordofobia, (re)existências e ativismo gordo, no que concerne às experiências de mulheres gordas durante a pandemia do novo coronavírus, tendo por diretriz relatos públicos postados no perfil @malijimenez, no Instagram. Para tanto, importam também as nossas experiências como mulheres gordas, numa perspectiva autoetnográfica, em diálogo com o aporte teórico-crítico que evidencia o campo dos estudos do corpo gordo, o movimento decolonial, o ativismo gordo e o feminismo decolonial em diálogo com o feminismo gordo. Objetivamos, nesse sentido, discutir de que modo a pandemia do novo coronavírus evidenciou a gordofobia no Brasil, ao tempo em que a exacerbou, bem como de quais formas têm se dado a atuação do ativismo de mulheres gordas nesse processo de enfrentamento ao preconceito. Realizamos, nesse sentido, um estudo autoetnográfico, de base qualitativa e de revisão bibliográfica, pautado em relatos pessoais de mulheres gordas publicados no perfil @malijimenez – direcionado ao ativismo gordo, no Instagram. Observamos que, apesar da gordofobia ter se intensificado na pandemia, muitas mulheres gordas construíram ferramentas de subversão e (re)existência.

Palavras-chave: Gordofobia. Covid-19. Estudos do corpo gordo. Feminismo gordo.
Validation and adjustment of modified Erasmus GBS outcome score in Bangladesh
Authors: Papri Nowshin , Doets Alex Y. , Mohammad Quazi D. , Endtz Hubert P. , Lingsma Hester F. , Jacobs Bart C. , Islam Zhahirul 
Published: July 2022

AbstractObjectiveWe have assessed and improved the performance of the modified Erasmus GBS Outcome Score (mEGOS) among patients with Guillain‐Barré syndrome (GBS) from Bangladesh.MethodsValidation cohort consisted of patients with GBS from two prospective cohort studies in Bangladesh. Poor outcome was defined as being unable to walk independently at week 4 and week 26. We excluded patients able to walk independently, patients who died within the first week, or with missing GBS disability scores. Performance of mEGOS at entry and week 1 was determined based on the discriminative ability (ability to differentiate between patients able and unable to walk independently; measured using the area under the receiver operating characteristic curves [AUC]) and calibration (observed probability versus predicted probability of poor outcome).ResultsA total of 506 patients aged ≥6‐year‐old were enrolled, with 471 and 366 patients included in mEGOS validation analysis at entry and week 1, respectively. The AUC values for predicting poor outcome (1) at week 4 were 0.69 (mEGOS entry) and 0.78 (mEGOS week 1) and (2) at week 26 were 0.67 (mEGOS entry) and 0.70 (mEGOS week 1). Mean predicted probabilities of poor outcome corresponded with observed outcomes except for the probability of poor outcome at week 4 which was overestimated by mEGOS week 1. This was resolved by updating the model intercept.InterpretationThe mEGOS shows valid outcome predictions among patients with GBS from Bangladesh. The model can aid the identification of patients at high risk of poor outcome and help to adequately allocate healthcare resources in low‐resource settings.
A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms
Authors: Xu Weijun , Qian Junmin , Hou Guanghui , Wang Taibing , Wang Jinlei , Wang Yaping , Yang Lijun , Cui Xinke , Suo Aili 
Published: July 2022

AbstractCuproptosis is a very newly recognized regulated cell death modality that is distinct from known death mechanisms and shows enormous prospect in cancer treatment. However, its efficacy is copper‐dependent and restricted by strictly regulated copper metabolism. Herein, a novel copper/iron hybrid hollow amorphous metal organic framework (HaMOF) is developed as an oxidative stress amplifier and copper/iron metabolic disrupter for synergistic cuproptosis/ferroptosis/apoptosis anticancer therapy. The HaMOF is fabricated from Cu2+, 3,3′‐dithiobis(propionohydrazide) and Fe3+ via an unsaturated coordination‐etching integration strategy, and then doxorubicin is loaded followed by surface decoration with hyaluronan. The obtained DOX@Fe/CuTH exhibits tumor microenvironment‐triggered catalytic therapeutic property, wherein it can amplify cellular oxidative stress by simultaneously boosting H2O2 production and depleting glutathione. Moreover, it can cause mitochondrial dysfunction and downregulate the expressions of copper transporter ATP7A and iron transporter FPN 1, thereby leading to metabolic disorders and high retentions of copper/iron in cytoplasm for •OH generation. The overloaded Cu2+ can cause lipoylated protein dihydrolipoamide S‐acetyltransferase aggregation and lead to cellular cuproptosis. Collectively, both augmented oxidative stress and overloaded copper/iron induce potent ferroptosis, which synergizes with cuproptosis and DOX‐mediated apoptosis to efficiently suppress tumor growth. This bimetallic hollow nanoplatform provides a new therapeutic modality paradigm to boost cuproptosis‐related therapies.
Cation‐π Interaction‐Mediated Tumour Drug Delivery for Deep Intratumoral Penetration and Treatment
Authors: Liu Chengfei , Li Muqiong , Sun Jianxiang , Li Pengxiang , Bai Yang , Zhang JuAn , Qian Yongchao , Shi Menghan , He Jia , Huo Hongbin , Pang Jun , Fan Li , Tian Wei 
Published: July 2022

AbstractThe limited efficacy of deep tumor treatments has been considered the “Achilles’ heel” of anticancer therapy due to multiple biological barriers. Whether passive diffusion or active transport has difficulties completely overcoming these obstacles. Herein, cation‐π interactions are utilized to construct a tumor drug delivery system integrating the merits of both passive and active transport mechanisms. A cation‐π interaction bridged trimetallic supramolecular drug complex (Cπ‐TMSDC) is constructed based on a drug consisting of one cisplatin molecule linked by K+ (Pt‐COOK) and the other drug with a Ru metal complex containing curcumin (Ru‐Cur). The obtained Cπ‐TMSDC further self‐assembles into cation‐π‐based trimetallic supramolecular drug micelles (Cπ‐TMSDMs) with efficient and stable transportation in vivo due to the strong cation‐π interaction formed between K+ and the curcumin unit in the Cπ‐TMSDC. In acidic tumor microenvironment, the cation‐π interaction smartly dissociates, facilitating the quick release of Pt‐COOK outside Cπ‐TMSDMs to rapidly infiltrate the outer cellular layers by passive diffusion. Meanwhile, the dissociated Ru‐Cur from the core layer of the Cπ‐TMSDMs form secondary self‐assemblies to deeply penetrate inside the solid tumor. Therefore, this strategy results in an efficient tumor drug delivery platform with enhanced deep intratumoral penetration, improved therapeutic effects, and reduced systemic toxicity to normal organs.
Engineering Prelithiation of Polyacrylic Acid Binder: A Universal Strategy to Boost Initial Coulombic Efficiency for High‐Areal‐Capacity Si‐Based Anodes
Authors: Li Zeheng , Tang Weiting , Yang Yajun , Lai Guoyong , Lin Zheng , Xiao Huayan , Qiu Juncheng , Wei Xiujuan , Wu Shuxing , Lin Zhan 
Published: July 2022

AbstractThe low initial Coulombic efficiency (ICE) and insufficient cycling lives of silicon (Si)‐based anodes seriously hinder their eventual introduction into next‐generation high‐energy‐density lithium–ion batteries (LIBs). Herein, an engineering prelithiation binder strategy based on polyacrylic acid (LixPAA) is proposed for representative SiOx anodes. The ICEs and cycling lives of SiOx anodes are significantly improved by precisely controlling the lithiation degree of PAA binder. The ICE of the high‐loading (3.0 mg cm−2) SiOx electrode increases by 10.9% when the Li0.75PAA binder replaces the PAA binder. Moreover, the working mechanism of the lithiation binder strategy to improve the electrochemical performances (especially for ICE) is systematically investigated, which is universally applied to other Si anodes such as Si nanoparticles and Si/graphite. This universal binder strategy and proposed working mechanism provide enlightenment on constructing high‐ICE, high‐energy‐density, and long‐life Si‐based anodes.
Dielectric Elastomer Architectures with Strain‐Tunable Permittivity
Authors: O'Neill Maura R. , Sessions Deanna , Arora Nitesh , Chen Vincent W. , Juhl Abigail , Huff Gregory H. , Rudykh Stephan , Shepherd Robert F. , Buskohl Philip R. 
Published: July 2022

AbstractFlexible hybrid electronic (FHE) materials and devices exploit the interaction of mechanical and electromagnetic properties to operate in new form factors and loading environments, which are key for advancing wearable sensors, flexible antennas, and soft robotic skin technologies. Dielectric elastomer (DE) architectures offer a novel substrate material for this application space as they are a class of strain‐tolerant and programmable metamaterials that derive their mechanical and dielectric properties from their architecture. Due to their hyperelasticity, dielectric elastomers can leverage reversible finite deformation to physically reconfigure their internal architecture to repeatedly tune their material behavior. Here a combined computational and experimental study of two dielectric elastomer architectures, based on square and hexagonal unit cell periodicities are presented. A shift in effective permittivity is observed due to the relative increase in matrix volume and the rearrangement of the electric field distribution in the cells. Additive fabrication allows rapid unit cell geometry customization for tuning the electromechanical response of the architectures. Effective permittivity shifts Δε2 > 0.7 under compressive strains of 35% are observed. The practical utility of this strain‐tunable permittivity is demonstrated in a microstrip patch antenna, which exhibits shifts in resonance frequency greater than 110 MHz when the dielectric elastomer substrate is compressed.
Time‐dependent prediction of mortality and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation using machine learning
Authors: Eisenberg Lisa ,   the XplOit consortium, Brossette Christian , Rauch Jochen , Grandjean Andrea , Ottinger Hellmut , Rissland Jürgen , Schwarz Ulf , Graf Norbert , Beelen Dietrich W. , Kiefer Stephan , Pfeifer Nico , Turki Amin T. 
Published: July 2022

AbstractAllogeneic hematopoietic cell transplantation (HCT) effectively treats high‐risk hematologic diseases but can entail HCT‐specific complications, which may be minimized by appropriate patient management, supported by accurate, individual risk estimation. However, almost all HCT risk scores are limited to a single risk assessment before HCT without incorporation of additional data. We developed machine learning models that integrate both baseline patient data and time‐dependent laboratory measurements to individually predict mortality and cytomegalovirus (CMV) reactivation after HCT at multiple time points per patient. These gradient boosting machine models provide well‐calibrated, time‐dependent risk predictions and achieved areas under the receiver‐operating characteristic of 0.92 and 0.83 and areas under the precision–recall curve of 0.58 and 0.62 for prediction of mortality and CMV reactivation, respectively, in a 21‐day time window. Both models were successfully validated in a prospective, non‐interventional study and performed on par with expert hematologists in a pilot comparison.
Antibody Response to HML‐2 May Be Protective in Amyotrophic Lateral Sclerosis
Authors: Garcia‐Montojo Marta , Simula Elena Rita , Fathi Saeed , McMahan Cynthia , Ghosal Anubrata , Berry James D. , Cudkowicz Merit , Elkahloun Abdel , Johnson Kory , Norato Gina , Jensen Peter , James Tony , Sechi Leonardo A. , Nath Avindra 
Published: July 2022

ObjectivesReactivation of HERV‐K(HML‐2) has been found in subsets of individuals with amyotrophic lateral sclerosis (ALS). This study examines the antibody response against HML‐2 in ALS and analyzes its clinical relevance.MethodsAntibodies to HML‐2 envelope (env) were analyzed using a peptide array for epitope mapping and by a peptide enzyme‐linked immunosorbent assay (ELISA) in 242 healthy donors, and 243 ALS and 85 multiple sclerosis (MS) individuals. Extracellular levels of HML‐2 were analyzed by digital polymerase chain reaction (PCR).ResultsAntibodies in the sera of ALS individuals recognized more HML‐2 env peptides compared to healthy controls (p < 0.0001). ALS individuals had higher levels of HML‐2 than healthy donors (p = 0.02) and higher antibody levels against a select HML‐2 env peptide compared to healthy donors or individuals with multiple sclerosis (p < 0.0001). 55.14% of ALS compared to 21.16% of healthy donors and 13.10% of MS individuals had antibodies against the HML‐2 peptide (AUC = 0.769, p < 0.0001). Levels of extracellular HML‐2 DNA in serum (p = 0.02) and the number of HML‐2 env peptides recognized by ALS sera (p = 0.02) correlated with disease duration. Among ALS individuals, lower levels of HML‐2 antibodies were associated with a definite diagnosis per EL Escorial criteria (p = 0.03), and with a lower predicted (p = 0.02) and observed survival (p = 0.03).InterpretationThere is a differential antibody response against specific epitopes of HML‐2 env in ALS and controls, suggesting epitope spreading, likely due to persistent antigenic exposure following reactivation of the viral genes. Low levels of antibodies to HML‐2 env in ALS are associated with poor prognosis and decreased survival probability. ANN NEUROL 2022;92:782–792
Influence of nanosized defects on photoluminescence efficiency of Er3+ ions co‐doped with Au2O3 in a lead boroselenate glass ceramic system: a novel approach using positron annihilation lifetime spectroscopy
Authors: Siva Sesha Reddy Annapureddy , Kostrzewa Marek , Ravi Kumar Valluri , Ingram Adam , Venkatramaiah Nutalapati , Sahaya Baskaran Gnanamuthu , Ravi Kumar Vandana , Veeraiah Nalluri 
Published: August 2022

AbstractThis study consists of the results of an investigation into the influence of the free‐volume space (fv) defects on luminescence efficiency (LE) of erbium ions in Au2O3‐doped PbO–B2O3–SeO2 (PBS) glass ceramics. Glass ceramics containing fixed concentrations of Er3+ ions and varied concentrations of Au2O3 were synthesized. X‐ray diffraction studies indicated that the samples contained Au2(SeO3)3 crystalline phase and nano gold metallic particles. The concentration of defects entrenched in the glass ceramics estimated in terms of Au2O3 content using positron annihilation lifetime spectroscopy measurement indicated the highest content in the glass ceramic containing 0.075 mol% of Au2O3. Optical absorption and the photoluminescence (PL) spectra of the glass ceramics were studied in the visible region. The observed increase of PL efficiency was attributed to the enhanced concentration of free‐volume imperfections in the samples. A perfect correlation could be achieved between the free‐volume fraction and the PL efficiency of erbium ions in these glass ceramics.
Managing electromyogram contamination in scalp recordings: An approach identifying reliable beta and gamma EEG features of psychoses or other disorders
Authors: Pope Kenneth J. , Lewis Trent W. , Fitzgibbon Sean P. , Janani Azin S. , Grummett Tyler S. , Williams Patricia A. H. , Battersby Malcolm , Bastiampillai Tarun , Whitham Emma M. , Willoughby John O. 
Published: August 2022

AbstractObjectiveIn publications on the electroencephalographic (EEG) features of psychoses and other disorders, various methods are utilized to diminish electromyogram (EMG) contamination. The extent of residual EMG contamination using these methods has not been recognized. Here, we seek to emphasize the extent of residual EMG contamination of EEG.MethodsWe compared scalp electrical recordings after applying different EMG‐pruning methods with recordings of EMG‐free data from 6 fully paralyzed healthy subjects. We calculated the ratio of the power of pruned, normal scalp electrical recordings in the six subjects, to the power of unpruned recordings in the same subjects when paralyzed. We produced “contamination graphs” for different pruning methods.ResultsEMG contamination exceeds EEG signals progressively more as frequencies exceed 25 Hz and with distance from the vertex. In contrast, Laplacian signals are spared in central scalp areas, even to 100 Hz.ConclusionGiven probable EMG contamination of EEG in psychiatric and other studies, few findings on beta‐ or gamma‐frequency power can be relied upon. Based on the effectiveness of current methods of EEG de‐contamination, investigators should be able to reanalyze recorded data, reevaluate conclusions from high‐frequency EEG data, and be aware of limitations of the methods.
MicroRNA‐204‐5p: A pivotal tumor suppressor
Authors: Yang Fan , Bian Zehua , Xu Peiwen , Sun Shengbai , Huang Zhaohui 
Published: July 2022

AbstractMicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a length of approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron of the transient receptor potential cation channel subfamily M member 3 (TRPM3) gene. MiR‐204‐5p is frequently downregulated in various cancer types and is related to the clinicopathological characteristics and prognosis of cancer patients. So far, many studies have determined that miR‐204‐5p functions as a tumor suppressor for its extensive and powerful capacity to inhibit tumor proliferation, metastasis, autophagy, and chemoresistance in multiple cancer types. MiR‐204‐5p appears to be a promising prognostic biomarker and a therapeutic target for human cancers. This review summarized the latest advances on the role of miR‐204‐5p in human cancers.
IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation
Authors: Cao Pei , Wu Yufan , Sun Ding , Zhang Weigang , Qiu Junyi , Tang Zuxiong , Xue Xiaofeng , Qin Lei 
Published: July 2022

AbstractBackgroundPancreatic carcinoma (PC) is a highly lethal cancer with an increasing mortality rate, its five‐year survival rate is only approximately 4%. N6‐methyladenosine (m6A) modification is the most common posttranscriptional modification of RNA, it could affect tumor formation by regulating m6A modifications in the mRNA of key oncogenes or tumor suppressor genes. However, its role in PC remains unclear.MethodsWe combined bioinformatic analysis with in vitro and in vivo experiments to investigate the expression profile of methylation modulators and identify key m6A regulators in the progression of PC. Further study focused on exploring the target genes binding to the regulators through RIP and immunofluorescence staining experiment.ResultsTCGA and Gene Expression Omnibus (GEO) analyses revealed an overall increasing trend in the expression of m6A regulators in PC, and consensus clustering analysis of m6A modification showed that the expression of regulators was negatively correlated with the survival rate. LASSO‐Cox regression analysis revealed that IGF2BP2, METTL3, ALKBH5 and KIAA1429 were associated with hazard ratios (HR), but only IGF2BP2 was sufficiently appropriate for the m6A survival prognosis model. The IHC and WB results verified high protein expression of IGF2BP2 in PC, and IGF2BP2 knockdown inhibited the proliferation and migration of PC cells. We predicted and verified B3GNT6 was observably regulated by IGF2BP2 via RIP assays. In addition, IF staining confirmed the co‐expression of IGF2BP2 and B3GNT6. The tumor‐promoting effect of IGF2BP2 and its co‐expression with B3GNT6 were verified in an animal model.ConclusionsElevated m6A levels promote PC progression. IGF2BP2 is a credible marker and modulates B3GNT6 mRNA stability, indicating that IGF2BP2 is a potential prognostic marker and therapeutic target in PC progression.
Genome‐wide analysis of colorectal cancer based on gene‐based somatic copy number alterations during neoplastic progression within the same tumor
Authors: Yamada Shun , Osakabe Mitsumasa , Uesugi Noriyuki , Yanagawa Naoki , Matsumoto Takayuki , Suzuki Hiromu , Sugai Tamotsu 
Published: August 2022

AbstractBackgroundThe objective of this study was to elucidate the association between neoplastic progression and somatic copy number alterations (SCNAs) occurring within the same colorectal cancer (CRC) tumor.MethodsWe investigated SCNAs to identify the progression from a high‐grade intramucosal lesion (HGIL) to an invasive front lesion (IFL), via an invasive submucosal lesion (ISL), within the same tumor using a crypt isolation method combined with a SNP array. Immunohistochemistry was also performed.ResultsWe identified 51 amplified genes that potentially promote progression from HGIL to ISL and 6 amplified genes involved in the progression from ISL to IFL. Of the 51 genes involved in HGIL to ISL progression, TORC1, MSLN, and STUB1, which are closely associated with CRC, were identified as candidate markers of submucosal invasion. However, no candidate genes were identified among the six genes associated with ISL to IFL progression. In addition, the number of total SCNAs and the number of gains were correlated with cancer progression (from HGIL to IFL). Finally, immunohistochemistry revealed higher expression of TORC1, MSLN, and STUB1 in ISL than in HGIL.ConclusionsThese results suggest that specific SCNAs are required for acquisition of invasive ability in CRC, and the affected genes are potential markers of invasion.
The Fluorescent Enzyme Cascade Detects Low Abundance Protein Modifications Suitable for the Assembly of Functionally Annotated Modificatome Databases
Authors: Hoppe Isabel J. , Prommegger Bernhard , Uhl Andreas , Lohrig Urs , Huber Christian G. , Brandstetter Hans 
Published: August 2022

AbstractPathophysiological functions of proteins critically depend on both their chemical composition, including post‐translational modifications, and their three‐dimensional structure, commonly referred to as structure‐activity relationship. Current analytical methods, like capillary electrophoresis or mass spectrometry, suffer from limitations, such as the detection of unexpected modifications at low abundance and their insensitivity to conformational changes. Building on previous enzyme‐based analytical methods, we here introduce a fluorescence‐based enzyme cascade (fEC), which can detect diverse chemical and conformational variations in protein samples and assemble them into digital databases. Together with complementary analytical methods an automated fEC analysis established unique modification‐function relationships, which can be expanded to a proteome‐wide scale, i. e. a functionally annotated modificatome. The fEC offers diverse applications, including hypersensitive biomarker detection in complex samples.
A laryngeal foreign body resembling cervical emphysema
Authors: Nishiori Hironobu , Tohma Takayuki , Fujita Hisanori , Yamaguchi Seiichi 
Published: August 2022

AbstractAn 81‐year‐old woman was referred to our hospital with a chief complaint of chest discomfort; CT imaging suggested for cervical emphysema. However, direct observation revealed a grilled liver stuck to the larynx. Carefully taking the patient's history, especially diet, is important to diagnose a laryngeal foreign body correctly.
A surgical treatment for frank rupture of acute type a small intramural hematoma
Authors: Ueda Daisuke , Niwa Kosuke , Nishikawa Hiroshi , Tsuchida Yasuaki , Yamashita Keigo 
Published: August 2022

AbstractA 71‐year‐old woman was admitted to the hospital due to cardiac tamponade. Computed tomography revealed that the diameter and wall thickness of the ascending aorta were 36 and 9 mm, respectively. An emergent ascending aortic replacement was performed uneventfully. The pathological findings indicated frank rupture of intramural hematoma.