bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-scale microbiome data integration enables robust biomarker identification
Authors: Xiao Liwen , Zhang Fengyi , Zhao Fangqing 
Published: May 2022

AbstractThe close association between gut microbiota dysbiosis and human diseases is being increasingly recognized. However, contradictory results are frequently reported, as confounding effects exist. The lack of unbiased data integration methods is also impeding the discovery of disease-associated microbial biomarkers from different cohorts. Here we propose an algorithm, NetMoss, for assessing shifts of microbial network modules to identify robust biomarkers associated with various diseases. Compared to previous approaches, the NetMoss method shows better performance in removing batch effects. Through comprehensive evaluations on both simulated and real datasets, we demonstrate that NetMoss has great advantages in the identification of disease-related biomarkers. Based on analysis of pandisease microbiota studies, there is a high prevalence of multidisease-related bacteria in global populations. We believe that large-scale data integration will help in understanding the role of the microbiome from a more comprehensive perspective and that accurate biomarker identification will greatly promote microbiome-based medical diagnosis.
Probing the nature of dissipation in compressible MHD turbulence
Authors: Richard Thibaud , Lesaffre Pierre , Falgarone Edith , Lehmann Andrew 
Published: May 2022

Context. An essential facet of turbulence is the space–time intermittency of the cascade of energy that leads to coherent structures of high dissipation.
Aims. In this work, we aim to systematically investigate the physical nature of the intense dissipation regions in decaying isothermal magnetohydrodynamical (MHD) turbulence.
Methods. We probed the turbulent dissipation with grid-based simulations of compressible isothermal decaying MHD turbulence. We took unprecedented care in resolving and controlling dissipation: we designed methods to locally recover the dissipation due to the numerical scheme. We locally investigated the geometry of the gradients of the fluid state variables. We developed a method to assess the physical nature of the largest gradients in simulations and to estimate their travelling velocity. Finally, we investigated their statistics.
Results. We find that intense dissipation regions mainly correspond to sheets; locally, density, velocity, and magnetic fields vary primarily in one direction. We identify these highly dissipative regions as fast and slow shocks or Alfvén discontinuities (Parker sheets or rotational discontinuities). On these structures, we find the main deviation from a 1D planar steady-state is mass loss in the plane of the structure. We investigated the effect of initial conditions, which yield different imprints at an early time on the relative distributions among these four categories. However, these differences fade out after about one turnover time, at which point they become dominated by weakly compressible Alfvén discontinuities. We show that the magnetic Prandtl number has little influence on the statistics of these discontinuities, but it controls the ohmic versus viscous heating rates within them. Finally, we find that the entrance characteristics of the structures (such as entrance velocity and magnetic pressure) are strongly correlated.
Conclusions. These new methods allow us to consider developed compressible turbulence as a statistical collection of intense dissipation structures. This can be used to post-process 3D turbulence with detailed 1D models apt for comparison with observations. It could also be useful as a framework to formulate new dynamical properties of turbulence.
Post-TIPS Hepatic Encephalopathy
Authors: Maleux Geert , Laleman Wim , Bonne Lawrence , Buyck Pieter-Jan , Nevens Frederik 
Published: May 2022

AbstractTransjugular intrahepatic portosystemic shunt (TIPS) procedures may be complicated by hepatic encephalopathy related to excessive shunting of portal venous blood into the systemic circulation without detoxification by the liver parenchyma. Although liver transplantation is the only curative treatment option, only a few patients can benefit from this procedure. In a first step, medical, conservative management is performed. In case of hepatic encephalopathy, refractory to medical management, several interventional techniques are available to reduce the diameter of the TIPS and subsequently, to reduce the volume of shunted portal venous blood. Technical aspects, devices and outcome results of these reduction procedures will be discussed as well as preventive procedures and devices which can be used during initial TIPS procedures.
Non-pharmacological Interventions for Improving Sleep Quality During Pregnancy: A Systematic Review and Meta-Analysis
Authors: Paulino Daiane Sofia Morais , Borrelli Carolina Bicudo , Faria-Schützer Débora Bicudo , Brito Luiz Gustavo Oliveira , Surita Fernanda Garanhani 
Published: May 2022

Abstract
Objective To investigate the effect of non-pharmacological interventions to improve sleep quality during pregnancy.
Data sources A search was made in the NCBI/PubMed, ClinicalTrials.gov, Embase, BVS, and Web of Science databases. There were no limitations regarding language, sample size, and type of non-pharmacological intervention. We have included prospective clinical trials between July 2014 and July 2019.
Selection of studies This study was registered in the Prospective International Registration of Systematic Reviews (PROSPERO) database was performed. Publication bias was also assessed with funnel plots. the primary outcome was the total score in the Pittsburgh Sleep Quality Index (PSQI) before and after intervention. Risk of bias and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria were used for assessing methodological quality. From the 28 retrieved studies, we have selected 8 for qualitative analysis and 6 for meta-analysis.
Data collection Two independent reviewers performed the study selection. In the case of disagreement, a third senior reviewer was consulted. The study was initially assessed based on the title, followed by abstract. Lastly, the full text was assessed to be included.
Data Synthesis A significant improvement on the sleep quality (PSQI score) was observed when all interventions were grouped (MD = -3.03, 95%CI -4.15 to -1.92, n = 623, i2 = 84%, p < 0.001). Analysis by subgroup (music listening: MD = -1.96, 95% CI -3.27 to -0.65, n = 207, i2 = 67%, p = 0.003 and other interventions: MD = -3.66, 95% CI -4.93 to -2.40, n = 416, i2 = 80%, p < 0.001) showed an improvement, with high heterogeneity. Risk of bias has shown performance and detection bias for almost studies, and GRADE evidence was very low for all analyzed variables.
Conclusion Non-pharmacological interventions—listening to music, physical exercise, relaxation exercises, lettuce seed, sleep hygiene, and acupressure—are effective for improving sleep quality during pregnancy.
The impact of COVID-19 on digital communication patterns
Authors: DeFilippis Evan , Impink Stephen Michael , Singell Madison , Polzer Jeffrey T. , Sadun Raffaella 
Published: May 2022

AbstractWe explore the impact of COVID-19 on employees’ digital communication patterns through an event study of lockdowns in 16 large metropolitan areas in North America, Europe, and the Middle East. Using de-identified, aggregated meeting and email meta-data from 3,143,270 users, we find, compared to pre-pandemic levels, increases in the number of meetings per person (+12.9 percent) and the number of attendees per meeting (+13.5 percent), but decreases in the average length of meetings (−20.1 percent). Collectively, the net effect is that people spent less time in meetings per day (−11.5 percent) in the post-lockdown period. We also find significant and durable increases in length of the average workday (+8.2 percent, or +48.5 min), along with short-term increases in email activity. These findings provide insight into how formal communication patterns have changed for a large sample of knowledge workers in major cities. We discuss these changes in light of the ongoing challenges faced by organizations and workers struggling to adapt and perform in the face of a global pandemic.
Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci
Authors: Ying Ying , Wang Maolin , Chen Yongheng , Li Meiqi , Ma Canjie , Zhang Junbao , Huang Xiaoyan , Jia Min , Zeng Junhui , Wang Yejun , Li Lili , Wang Xiaomei , Tao Qian , Shu Xing-sheng 
Published: May 2022

Significance
This study uncovered the role of ZNF280C, a known DNA damage response protein, as a tumorigenic transcription regulator that contributes to colorectal tumorigenesis and metastasis through maintaining an epigenetic repression program at key cancer gene loci. These findings identified a contributor with potential prognostic value to colorectal pathogenesis and provide mechanistic insight to the essential function of transcription factor in fine-tuning the activity of chromatin regulators for proper transcription control.
Enhanced spatial resolution in magnetic resonance imaging by dynamic nuclear polarization at 5 K
Authors: Chen Hsueh-Ying , Wilson C. Blake , Tycko Robert 
Published: May 2022

Significance
Although MRI is a powerful method for visualizing features within organisms and materials, the relatively low signal-to-noise ratio (SNR) of the NMR signals that are used to construct an image makes MRI with isotropic spatial resolution below 3.0 μm impractical at room temperature. Here we show that SNR enhancements available from a combination of low temperatures and dynamic nuclear polarization allow MRI with 1.7-μm isotropic resolution. These results may enable informative MRI studies of eukaryotic cells, cell clusters, and small tissue samples.
Aerosol particle emission increases exponentially above moderate exercise intensity resulting in superemission during maximal exercise
Authors: Mutsch Benedikt , Heiber Marie , Grätz Felix , Hain Rainer , Schönfelder Martin , Kaps Stephanie , Schranner Daniela , Kähler Christian J. , Wackerhage Henning 
Published: May 2022

Significance
Airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or other pathogens is probably increased during indoor exercise, but data on the emission of aerosol particles by an exercising individual are lacking. Here, we report that aerosol particle emission increases on average 132-fold from 580 ± 489 particles/min at rest to 76,200 ± 48,000 particles/min during maximal exercise. Aerosol particle emission increases moderately up to an exercise intensity of ≈2 W/kg and exponentially at higher exercise intensities. These data not only explain SARS-CoV-2 transmissions during indoor group exercise but also can be used to design better targeted mitigation measures for physical activity indoors such as physical education in school, dance events during weddings, or high-intensity gym classes such as spinning.
Evaluating audio description and emotional engagement for BPS visitors in a museum context
Authors: Wang Xi , Crookes Danny , Harding Sue-Ann , Johnston David 
Published: May 2022

Abstract
Museums face a particular challenge in enabling blind and partially sighted (BPS) visitors to engage emotionally with the narrative(s) they present. In collaboration with a world-leading tourist attraction (Titanic Belfast) and the Royal National Institute of Blind People (RNIB), we have applied several different approaches for improving emotional engagement for BPS visitors. This paper addresses the critical challenge of how to obtain reliable evidence for evaluating the emotional response of BPS visitors to the museum’s audio description (AD) and overall experience. We consider six different methods for measuring emotional engagement, and consider their potential for providing reliable experimental evidence. Based on BPS-user feedback, we present a qualitative comparison of these methods, uniquely all applied to the same museum context.
Effect of external load on muscle activation during the barbell back squat
Authors: Martinez Sarah C. , Coons John M. , Mehls Kelton D. 
Published: May 2022

ABSTRACTThe aim of this study was to compare gluteus maximus‐to‐hamstring (GM:H) co‐activation, hamstrings‐to‐quadriceps (H:Q) co‐activation, and mean muscle activity in the vastus lateralis (VL), vastus medialis (VM), rectus femoris (RM), gluteus maximus (GM), semitendinosus (ST), and bicep femoris (BF) muscles across a range of training loads (40%, 50%, 50%, 70%, 80% 90% 1RM) of the barbell back squat in resistance trained females. Surface electromyography (EMG) was observed in 18 healthy resistance trained females for the VL, VM, RM, GM, ST, and BF during the ascending and descending phase of the back squat. During the ascending phase, the VL, VM, RM, GM, ST, and BF displayed significantly more EMG activation at 90% 1RM compared to 40%–70% (p < .03). During the descending phase, there were no significant differences displayed in mean muscle activity at 40%–80% of 1RM compared to 90% of 1RM. There were no significant differences in H‐Q co‐activation and GM‐H co‐activation during the ascending or descending phase across external loads. These findings are similar to the results found in similar studies using male participants and support that higher training intensities (80%–90% 1RM) of the barbell back squat significantly activate muscles surrounding the hip compared to lower loads (40%–70%). The results of this study also suggest that training intensities of 80% 1RM and 90% 1RM elicits the similar musculature activation in the muscle surrounding the hip in resistance trained females.Highlights
During the back squat, mean muscle activity of the hip and leg muscles increased linearly with exercise intensity (40%–90% of one‐repetition max) in resistance trained females.
No significant difference in mean activity were noted between 80% and 90% of one‐repetition max during the ascending and descending phases.
During the ascending phase, 80% of one‐repetition max generated the highest gluteus maximus to hamstring activity co‐activation ratio.
During the descending phase, 40% of one‐repetition max produced a gluteus maximus to hamstring activity co‐activation ratio closest to 1.0.
Application of the Lagrange-mesh method in continuum-discretized coupled-channel calculations
Authors: Chen Wendi , Guo Hairui , Ye Tao , Ying Yangjun , Sun Weili , Han Yinlu 
Published: May 2022

Abstract
We apply the Lagrange-mesh method to discretize continuum states of weakly bound nuclei for continuum-discretized coupled-channel (CDCC) calculations of three-body breakup reactions. This discretization method is compared with the bin method, which is regarded as the standard continuum discretization method, for the d and 6Li induced reactions. An improved Numerov algorithm is used to solve the coupled channels equations, which permits a fast integration of equations and a convenient treatment of the closed channels. A new CDCC model code named CDCC-R is developed. In all cases, the combination of the Lagrange-mesh method and the Numerov algorithm shows high efficiency and accuracy for the CDCC calculations of the elastic scattering and breakup reactions. Especially, various numerical and physical aspects are discussed for 6Li induced reactions. The coupling effects of the continuum states with high orbital angular momentum and closed channels are discussed. Moderate effects are found in the calculations for elastic scattering and breakup reaction when F- and G-wave continuum states are included in CDCC model space for 6Li induced reactions at the incident energies well above the Coulomb barrier. The closed channel effect is found to be indispensable for 6Li breakup reaction calculation when the incident energy is around the Coulomb barrier.
CTA sensitivity on TeV scale dark matter models with complementary limits from direct detection
Authors: Duangchan C. , Pongkitivanichkul C. , Uttayarat P. , Jardin-Blicq A. , Wechakama M. , Klangburam T. , Treesukrat W. , Samart D. , Sawangwit U. , Aguirre-Santaella A. , Sánchez-Conde M.A. 
Published: May 2022

Abstract
With ever increasing pressure from collider physics and direct detection experiments, particle physics models of TeV scale dark matter are gaining more attention. In this work, we consider two realizations of the class of scalar portal dark matter scenarios — the inverse seesaw model and the inert doublet model. Observations by the Cherenkov Telescope Array (CTA) of very-high-energy γ rays from dark matter annihilation in the context of these models are simulated for the Draco and Sculptor dwarf spheroidal galaxies, and later analyzed using ctools. We study the potential of CTA for the 5σ detection of a dark matter annihilation signal.
In the absence of a signal, we also derive the 2σ upper limits on the annihilation cross-section. We compare our projected CTA sensitivity against the projected sensitivity of the next generation of direct detection experiment, i.e. XENONnT. Although the limits from CTA are significantly improved compared with the previous generations of γ-ray experiments, they are still ∼2 orders of magnitude above the thermal relic cross-section for the considered targets. In the case of the inverse seesaw model, the constraint from the future direct detection experiment XENONnT is much weaker than the CTA sensitivity, whereas for the inert doublet model, XENONnT gives a bound an order of magnitude stronger compared to the CTA limits.
Enhanced multicolor optomechanically induced transparency in electro-optical hybrid system
Authors: Pan Guixia , Xiao Ruijie , Zhai Chengbo 
Published: May 2022

Abstract
We investigate the tunable multicolor optomechanically induced transparency through electro-optical hybrid system. The system consists an optical cavity fulled with three-level atomic ensemble and two charged mechanical oscillators coupled via Coulomb interaction. Under different coupling strengths, the system can exhibit the phenomena of optomechanical induced transparency increase. Specifically, the number of the transparency windows increases with the presence of charged mechanical resonators and atoms. Furthermore, the induced transparency phenomena are strongly manipulated by the coupling strength between the optical mode and the mechanical mode, or between the optical mode and the atoms and the Rabi frequency, or between the Coulomb coupling between the two charged mechanical modes. It is found that the larger coupling strength between the cavity field and the atoms and the mechanical oscillator, the wider transparent windows. Our approach is feasible for storage of light and has potential applications in quantum information processing.
Density fluctuations of two-dimensional active-passive mixtures
Authors: Zhang Jian , Huang Tao , Xu Guoqing , Chen Yong 
Published: May 2022

Abstract
Dimension-dependent giant density fluctuations are a typical feature of active matter systems. In this work, we study the density fluctuation in two-dimensional mixtures of active and passive particles by Brownian dynamics simulations. The boundary of motility-induced phase separation is determined by the transition from unimodal to bimodal density distribution. A rapid increase of the fluctuation exponent near the boundary of phase separation in the plane of density and Péclet number was observed. When phase separation occurs, the fluctuation exponent is an approximate constant of

0.85
.
On Magnetic-coupled Matrix Rectifier Applied to Accelerator Power Supply
Authors: Wang Bin , Si Yang , Zhou Zhiwen 
Published: May 2022

Abstract
The power supply designing of superconducting magnet is vital for magnetic field system in the development of accelerator. Magnet power supply can still be improved in grid-side power factor, and better cost-effective solutions can be sought. For release or consumption of the huge energy stored in the future superconducting magnet, so that it is urgent to carry out related research to solve the energy feedback problem. Utilizing the characteristics of adjustable power factor and bi-directional energy transfer of matrix converter, a novel magnetic-coupled matrix rectifier topology is presented, which is suitable for accelerator power supply. An improved control strategy is proposed to realize sinusoidal waveform of input current, unity input power factor as well as output current tracking the instruction current waveform. Prototype test shows that the matrix converter can realize DC output and the control strategy can achieve expected requirements. Load disturbance experiment of quasi-trapezoidal wave output is preliminarily verified. The matrix converter studied in the paper, as a kind of feasible attractive choice of accelerator power converter topology, has a favorable research prospect.
CFAR Detector Based on the Identification of Sea Clutter Distribution Characteristics
Authors: Li Bowen , Liu Xiaoming , Du Shasha , Li Wanhan 
Published: May 2022

Abstract
To improve the capability of radar detection in a time-varying maritime environment, an algorithm was proposed and analyzed in this paper that can be applied to determine the shape and scale parameters of the K-distributed model using the radar parameters and environmental information under the context of K-distributed sea clutter, and improved the original algorithm to improve the accuracy of the parameter estimation algorithm. Furthermore, a CFAR detector capable of identifying the characteristics of sea clutter distribution was developed. It can estimate the parameters of K-distributed model for sea clutter in real time using both radar parameters and environmental perception information, thus improving the accuracy of clutter background estimation. When the false alarm rate reaches a certain level, the adaptive threshold factor can be obtained for the CFAR detector proposed in this paper, thus improving the effectiveness of control on the CFAR detector. As suggested by the simulation results, the proposed method outperforms the CFAR detector with fixed parameters in the capability of detection and robustness under the context of K-distributed clutter.
Design of high voltage electrostatic protection device for CAN bus
Authors: Su Xuebing , Wang Yang , Jin Xiangliang , Yang Hongjiao 
Published: May 2022

Abstract
The Dual-Direction Silicon Controlled Rectifier (DDSCR) device has dual-direction electrostatic protection function and strong current discharging ability, which is widely used in ESD on-chip protection. In this paper, a high performance symmetric high voltage Dual-Direction Silicon Controlled Rectifier with floating P+ (HVDDSCR_FP+) is designed for CAN bus under 0.18 μm BCD process. In order to predict and verify the ESD performance of the device, TCAD two-dimensional device simulation and Transmission Line Pulse (TLP) test system were used. The experimental results show that the HVDDSCR_FP + structure has not only symmetrical positive and reverse I-V curves, but also the characteristics of high holding voltage and high failure current. Compared with the traditional HVDDSCR, HVDDSCR_FP+, at 25V forward and reverse trigger voltages (Vt), has increased its holding voltage (Vh) from 12V to 20V, failure current (It2) from 5A to 35A. In the actual tape-out process, it is found that the width of the N-well has a great influence on the performance of the device. After analyzing the reason and improving it, the leakage current of the device is reduced from μA level to nA level.
Transformer evaluation strategy based on improved machine learning
Authors: Wu Tianyi , Xu Xiangyi , Chen Lu , Tang Weijie 
Published: May 2022

Abstract
A transformer state assessment method based on an improved extreme learning machine is proposed in this paper, which introduces an adaptive evolution algorithm into the extreme learning machine. This method is used in the evaluation model to evaluate the state of the transformer. The algorithm is trained and tested through sample sets. Furthermore, the test results are analyzed to prove the feasibility of the proposed control strategy.