bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collective pursuit for equity in cancer care: The National Navigation Roundtable
Authors: Dwyer Andrea J. , Wender Richard C. , Staples Elsa S. , Dean Monica S. , Sharpe Katherine , Fleisher Linda , Burhansstipanov Linda , Johnson Wenora , Martinez Laura , Wiatrek Dawn E. , Calhoun Elizabeth , Battaglia Tracy A. ,   the National Navigation Roundtable
Published: June 2022

BACKGROUNDThe evidence continues to build in support of implementing patient navigation to reduce barriers and increase access to care. However, health disparities remain in cancer outcomes. The goal of the National Navigation Roundtable (NNRT) is to serve as a convener to help support the field of navigation to address equity.METHODSTo examine the progress and opportunities for navigation, the NNRT submitted a collection of articles based on the results from 2 dedicated surveys and contributions from member organizations. The intent was to help inform what we know about patient navigation since the last dedicated examination in this journal 10 years ago.RESULTSThe online survey of >700 people described navigators and examined sustainability and policy issues and the longevity, specific role and function, and impact of clinical and nonclinical navigators in addition to the role of training and supervision. In addition, a full examination of coronavirus disease 2019 and contributions from member organizations helped further define progress and future opportunities to meet the needs of patients through patient navigation.CONCLUSIONSTo achieve equity in cancer care will demand the sustained action of virtually every component of the cancer care system. It is the hope and intent of the NNRT that the information presented in this supplement will be a catalyst for action in this collective action approach.
Creating orthophotos with unmanned aerial vehicles and examining its accuracy and usability in geodetic applications
Authors: Divit Kadi Ayse , Gokalp Ertan , Kadi Fatih 
Published: June 2022

SummaryUnmanned aerial vehicles, one of the technologies that aim to produce data in many scientific studies, has widespread use in many engineering applications, especially in cartography applications. UAV, which can meet the high accuracy required in many studies, offer users the opportunity to produce point cloud and maps for various aims. It is aimed to produce a high‐resolution orthophoto map of the study area in this study. In addition, the accuracy of the orthophoto map produced for the areas classified according to topographic structures in the study area has been checked with GNSS measurements, and its compliance with the standards specified in the regulation has been examined. According to the results; Considering the root square mean error values of three axes, it has been searched whether the accuracy values of the products obtained are suitable according to the regulation and it has been determined that these values are within the limits. Then, the application of testing the accuracy of the orthophoto map has been started. When all checkpoints have been examined, the maximum error values in x, y, and h directions have been found to be 5.9, 4.5, and 4.9 cm, respectively.
The moderating effect of contextual factors and employees' demographic features on the relationship between CSR and work‐related attitudes: A meta‐analysis
Authors: Garrido‐Ruso María , Aibar‐Guzmán Beatriz 
Published: June 2022

AbstractThis paper aims to identify the conditions under which corporate social responsibility (CSR) affects employees' work‐related attitudes. A meta‐analysis of 42 studies published between 1999 and 2019 is elaborated considering the moderating effect of several contextual factors (country, industry, and national culture' values) and employees' demographic features (gender, age, education, tenure, and position) on the impact of perceived CSR on three work‐related attitudes (organizational identification, commitment, and turnover intentions). The results reveal that the positive impact of CSR in employees' attitudes is not universal, it may vary due to the level of development and the national culture of the country where a company operates, the industry to which it belongs as well as employees' age and position. Furthermore, although individually some variables do not have a significant moderating effect, they are significant in combination with other variables, which opens new research avenues. The findings provide valuable help to human resource management policies.
An improved adaptive spherical unscented Kalman filtering method for the accurate state‐of‐charge estimation of lithium‐ion batteries
Authors: Qi Chuangshi , Wang Shunli , Cao Wen , Yu Peng , Xie Yanxin 
Published: June 2022

AbstractThe state of charge (SOC) of lithium‐ion batteries is the main parameter of the battery management system. To improve the accuracy of lithium‐ion battery SOC estimation, this paper uses a double RC physical characteristic circuit network to model the polarization reaction inside the battery and realizes the full parameter identification of the model based on the double‐exponential fitting strategy. Then, using the spherical unscented transform (SUT) to realize the selection of sigma points and the calculation of weight coefficients, at the same time, the adaptive factor is introduced to correct the error covariance matrix in real time and an adaptive spherical unscented Kalman filter (AS‐UKF) algorithm. Finally, the algorithm is compared with the unscented Kalman filter (UKF) and adaptive unscented Kalman filter (AUKF) algorithms through simulation. The results show that the average error of the AS‐UKF algorithm is reduced by 0.5% and 1.18% under the Hybrid Pulse Power Characterization (HPPC) and the Beijing Bus Dynamic Street Test (BBDST) conditions. The AS‐UKF algorithm not only improves the accuracy but also is more stable.
Cascadia Burning: The historic, but not historically unprecedented, 2020 wildfires in the Pacific Northwest,USA
Authors: Reilly Matthew J. , Zuspan Aaron , Halofsky Joshua S. , Raymond Crystal , McEvoy Andy , Dye Alex W. , Donato Daniel C. , Kim John B. , Potter Brian E. , Walker Nathan , Davis Raymond J. , Dunn Christopher J. , Bell David M. , Gregory Matthew J. , Johnston James D. , Harvey Brian J. , Halofsky Jessica E. , Kerns Becky K. 
Published: June 2022

AbstractWildfires devastated communities in Oregon and Washington in September 2020, burning almost as much forest west of the Cascade Mountain crest (“the westside”) in 2 weeks (~340,000 ha) as in the previous five decades (~406,00 ha). Unlike dry forests of the interior western United States, temperate rain forests of the Pacific Northwest have experienced limited recent fire activity, and debates surrounding what drove the 2020 fires, and management strategies to adapt to similar future events, necessitate a scientific evaluation of the fires. We evaluate five questions regarding the 2020 Labor Day fires: (1) How do the 2020 fires compare with historical fires? (2) How did the roles of weather and antecedent climate differ geographically and from the recent past (1979–2019)? (3) How do fire size and severity compare to other recent fires (1985–2019), and how did forest management and prefire forest structure influence burn severity? (4) What impact will these fires have on westside landscapes? and (5) How can we adapt to similar fires in the future? Although 5 of the 2020 fires were much larger than any others in the recent past and burned ~10 times the area in high‐severity patches >10,000 ha, the 2020 fires were remarkably consistent with historical fires. Reports from the early 1900s, along with paleo‐ and dendro‐ecological records, indicate similar and potentially even larger wildfires over the past millennium, many of which shared similar seasonality (late August/early September), weather conditions, and even geographic locations. Consistent with the largest historical fires, strong east winds and anomalously dry conditions drove the rapid spread of high‐severity wildfire in 2020. We found minimal difference in burn severity among stand structural types related to previous management in the 2020 fires. Adaptation strategies for similar fires in the future could benefit by focusing on ignition prevention, fire suppression, and community preparedness, as opposed to fuel treatments that are unlikely to mitigate fire severity during extreme weather. While scientific uncertainties remain regarding the nature of infrequent, high‐severity fires in westside forests, particularly under climate change, adapting to their future occurrence will require different strategies than those in interior, dry forests.
Modeling metal forming of a magnesium alloy using an adapted material model
Authors: Wolf Alexander , Küsters Niklas , Bräunling Sven , Weck Daniel , Kittner Kristina , Gude Maik , Prahl Ulrich , Brosius Alexander 
Published: June 2022

AbstractModeling sheet metal forming of materials for lightweight construction requires an understanding of their plastic behavior in different loading directions. The presented work focuses on twin‐roll‐casted magnesium alloy AZ31. It is characterized by unique mechanical properties compared to other magnesium alloys due to the employed twin‐roll‐casting‐process. In general, magnesium alloys with their hexagonal closed‐packed structure possess a complex forming behavior including a deformation‐induced anisotropy evolution. In the context of a fast design approach, an adaptation of the Yield2000‐2d criteria usually used for body‐centered cubic or face‐centered cubic materials is tested. The goal is a simple, versatile material model which parameters are determined just by tensile tests with moderate testing effort. In the investigated model, the yield locus definition is modified by adding a term for the yield exponent evolution during the forming process. The modeling approach is presented and the necessary tests for material data acquisition and evaluation are described. After experimental identification of the model parameters, the material model is applied in a forming simulation. The investigation provides promising results matching well with experimental data. Thus, the application of this model in a fast design step is feasible, offering valuable data like deformed shape, process‐related material properties and induced stresses for further processing.
Soil Ecotoxicology Needs Robust Biomarkers: A Meta-Analysis Approach to Test the Robustness of Gene Expression-Based Biomarkers for Measuring Chemical Exposure Effects in Soil Invertebrates
Authors: Swart Elmer , Martell Ellie , Svendsen Claus , Spurgeon David J. 
Published: June 2022

Abstract
Gene expression-based biomarkers are regularly proposed as rapid, sensitive, and mechanistically informative tools to identify whether soil invertebrates experience adverse effects due to chemical exposure. However, before biomarkers could be deployed within diagnostic studies, systematic evidence of the robustness of such biomarkers to detect effects is needed. In our study, we present an approach for conducting a meta-analysis of the robustness of gene expression-based biomarkers in soil invertebrates. The approach was developed and trialed for two measurements of gene expression commonly proposed as biomarkers in soil ecotoxicology: earthworm metallothionein (MT) gene expression for metals and earthworm heat shock protein 70 (HSP70) gene expression for organic chemicals. We collected 294 unique gene expression data points from the literature and used linear mixed-effect models to assess concentration, exposure duration, and species effects on the quantified response. The meta-analysis showed that the expression of earthworm MT was strongly metal concentration dependent, stable over time and species independent. The metal concentration-dependent response was strongest for cadmium, indicating that this gene is a suitable biomarker for this metal. For copper, no clear concentration-dependent response of MT gene expression in earthworms was found, indicating MT is not a reliable biomarker for this metal. For HSP70, overall marginal up-regulation and lack of a concentration-dependent response indicated that this gene is not suitable as a biomarker for organic pollutant effects in earthworms. The present study demonstrates how meta-analysis can be used to assess the status of biomarkers. We encourage colleagues to apply this open-access approach to other biomarkers, as such quantitative assessment is a prerequisite to ensuring that the suitability and limitations of proposed biomarkers are known and stated. Environ Toxicol Chem 2022;41:2124–2138. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Methyltransferase 1 is required for nonhomologous end‐joining repair and renders hepatocellular carcinoma resistant to radiotherapy
Authors: Liao Junbin , Yi Yang , Yue Xin , Wu Xiaoxue , Zhu Meiyan , Chen Yong , Peng Sui , Kuang Ming , Lin Shuibin , Peng Zhenwei 
Published: June 2022

Background and Aims:
Radiotherapy is an increasingly essential therapeutic strategy in the management of hepatocellular carcinoma (HCC). Nevertheless, resistance to radiotherapy is one of the primary obstacles to successful treatment outcomes. Hence, we aim to elucidate the mechanisms underlying radioresistance and identify reliable biotargets that would be inhibited to enhance the efficacy of radiotherapy in HCC.

Approach and Results:
From a label‐free quantitative proteome screening, we identified transfer RNA (tRNA; guanine‐N [7]‐) methyltransferase 1 (METTL1), a key enzyme for N7‐methylguanosine (m7G) tRNA modification, as an essential driver for HCC cells radioresistance. We reveal that METTL1 promotes DNA double‐strand break (DSB) repair and renders HCC cells resistant to ionizing radiation (IR) using loss‐of‐function and gain‐of‐function assays in vitro and in vivo. Mechanistically, METTL1‐mediated m7G tRNA modification selectively regulates the translation of DNA‐dependent protein kinase catalytic subunit or DNA ligase IV with higher frequencies of m7G‐related codons after IR treatment, thereby resulting in the enhancement of nonhomologous end‐joining (NHEJ)–mediated DNA DSB repair efficiency. Clinically, high METTL1 expression in tumor tissue is significantly correlated with poor prognosis in radiotherapy‐treated patients with HCC.

Conclusions:
Our findings show that METTL1 is a critical enhancer for HCC cell NHEJ‐based DNA repair following IR therapy. These findings give insight into the role of tRNA modification in messenger RNA translation control in HCC radioresistance.
Iron overload disorders
Authors: Hsu Christine C. , Senussi Nizar H. , Fertrin Kleber Y. , Kowdley Kris V. 
Published: June 2022

Abstract
Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver enzymes. Confirmatory homeostatic iron regulator (HFE) genetic testing for C282Y and H63D, mutations most encountered in hereditary hemochromatosis, should be pursued in evaluation of hyperferritinemia. Magnetic resonance imaging with quantitative assessment of iron content or liver biopsy (especially if liver disease is a cause of iron overload) should be used as appropriate. A secondary cause for iron overload should be considered if HFE genetic testing is negative for the C282Y homozygous or C282Y/H63D compound heterozygous mutations. Differential diagnosis of secondary iron overload includes hematologic disorders, iatrogenic causes, or chronic liver diseases. More common hematologic disorders include thalassemia syndromes, myelodysplastic syndrome, myelofibrosis, sideroblastic anemias, sickle cell disease, or pyruvate kinase deficiency. If iron overload has been excluded, evaluation for causes of hyperferritinemia should be pursued. Causes of hyperferritinemia include chronic liver disease, malignancy, infections, kidney failure, and rheumatic conditions, such as adult‐onset Still's disease or hemophagocytic lymphohistiocytosis. In this review, we describe the diagnostic testing of patients with suspected hereditary hemochromatosis, the evaluation of patients with elevated serum ferritin levels, and signs of secondary overload and treatment options for those with secondary iron overload.
Sentinel lymph node mapping in endometrial cancer: A comparison of main national and international guidelines
Authors: Dick Aharon , Perri Tamar , Kogan Liron , Brandt Benny , Meyer Raanan , Levin Gabriel 
Published: June 2022

AbstractObjectivesTo compare national and international guidelines regarding sentinel lymph node (SLN) mapping in endometrial cancer.MethodsA descriptive comparative study of the National Comprehensive Cancer Network (NCCN), the Society of Gynecologic Oncology (SGO), the European Society of Gynecological Oncology (ESGO), the British Gynecological Cancer Society (BGCS), and the Japan Society of Gynecologic Oncology (JSGO) guidelines.ResultsThere is a broad consensus that SLN mapping is an appropriate alternative to pelvic lymphadenectomy for uterine‐confined endometrioid endometrial cancer (five of five guidelines). It is broadly accepted that a full lymphadenectomy should be performed in case of failed SLN mapping (four of five guidelines), and that mapping with the fluorescent dye indocyanine green is superior to other methods (four of five guidelines). It is agreed that the cervix is the preferable site for dye injection (four of five guidelines), and pathology ultrastaging is advocated by most guidelines (three of five guidelines). Regarding high‐risk patients (i.e., high‐grade histology and non‐endometroid carcinomas), some guidelines accept (three of five), but others currently do not advocate (one of five guidelines), SLN mapping as a sole method for lymph node evaluation. There is no consensus regarding para‐aortic lymph node evaluation in pelvic SLN‐positive patients.ConclusionGuidelines for SLN mapping are comparable with regards to surgical technique, ultrastaging, and management in case of failed mapping. Nevertheless, some variations exist regarding the management of high‐grade histology and positive pelvic lymph nodes.
Interactive effects of high temperature and pesticide exposure on oxidative status, apoptosis, and renin expression in kidney of goldfish: Molecular and cellular mechanisms of widespread kidney damage and renin attenuation
Authors: Lacy Brittney , Rahman Md Saydur 
Published: June 2022

AbstractOne of many noteworthy consequences of increasing societal reliance on pesticides is their predominance in aquatic environments. These pernicious chemicals interact with high temperatures from global climate change, heat waves, and natural variations to create unstable environments that negatively impact organisms' health. To understand these conditions, we examined the dose‐dependent effects of environmentally relevant pesticide mixtures (metolachlor, linuron, isoproturon, tebuconazole, aclonifen, atrazine, pendimethalin, and azinphos‐methyl) combined with elevated temperatures (22 control vs. 32°C for 4‐week exposure) on renin, dinitrophenyl protein (DNP, an indicator of reactive oxygen species, ROS), 3‐nitrotyrosine protein (NTP, an indicator of reactive nitrogen species, RNS), superoxidase dismutase (SOD, an antioxidant), and catalase (CAT, an antioxidant) expressions in the kidneys of goldfish (Carassius auratus). Histopathological analysis showed widespread damage to kidney tissues in high temperature and pesticide co‐exposure groups, including rupture of the epithelial layer, hemorrhaging, and degeneration of tubular epithelium. Quantitative real‐time polymerase chain reaction (qRT‐PCR) and immunohistochemical analyses demonstrated significant declines in renin receptor‐like mRNA and protein expressions in kidney tissues under combined exposure to high temperature and pesticides compared with controls; conversely, expression of DNP, NTP, SOD, and CAT increased in kidney tissues under the same conditions. Apoptotic cells were also increased in co‐exposure groups as assessed by in situ terminal deoxynucleotidyl transferase dUTP nick labeling (TUNEL) assay. The enhanced apoptosis in kidneys of heat and pesticides co‐exposed fish was associated with increased caspase‐3 (a protease enzyme) mRNA levels. Our results demonstrated that high temperature and pesticides induced oxidative/nitrative stress (i.e., ROS/RNS), damaged tissues, increased cellular apoptosis, and suppressed renin expression in kidneys of goldfish.
Longitudinal Associations of High-Volume and Vigorous-Intensity Exercise With Hip Fracture Risk in Men
Authors: Korhonen Marko T. , Kujala Urho M. , Kettunen Jyrki , Korhonen Olga V. , Kaprio Jaakko , Sarna Seppo , Törmäkangas Timo 
Published: June 2022

ABSTRACT
Maintenance of vigorous exercise habits from young to old age is considered protective against hip fractures, but data on fracture risk in lifelong vigorous exercisers are lacking. This longitudinal cohort study examined the hazard of hip fractures in 1844 male former athletes and 1216 population controls and in relation to exercise volume and intensity in later years. Incident hip fractures after age 50 years were identified from hospital discharge register from 1972 to 2015. Exercise and covariate information was obtained from questionnaires administered in 1985, 1995, 2001, and 2008. Analyses were conducted using extended proportional hazards regression model for time-dependent exposures and effects. During the mean ± SD follow-up of 21.6 ± 10.3 years, 62 (3.4%) athletes and 38 (3.1%) controls sustained a hip fracture. Adjusted hazard ratio (HR) indicated no statistically significant difference between athletes and controls (0.84; 95% confidence interval [CI], 0.55–1.29). In subgroup analyses, adjusted HRs for athletes with recent high (≥15 metabolic equivalent hours [MET-h]/week) and low (&lt;15 MET-h/week) exercise volume were 0.83 (95% CI, 0.46–1.48) and 1.04 (95% CI, 0.57–1.87), respectively, compared with controls. The adjusted HR was not statistically significant between athletes with low-intensity exercise (&lt;6 METs) and controls (1.08; 95% CI, 0.62–1.85). Athletes engaging in vigorous-intensity exercise (≥6 METs at least 75 minutes/week) had initially 77% lower hazard rate (adjusted HR 0.23; 95% CI, 0.06–0.86) than controls. However, the HR was time-dependent (adjusted HR 1.04; 95% CI, 1.01–1.07); by age 75 years the HRs for the athletes with vigorous-intensity exercise reached the level of the controls, but after 85 years the HRs for these athletes increased approximately 1.3-fold annually relative to the controls. In conclusion, these data suggest that continuation of vigorous-intensity exercise is associated with lower HR of hip fracture up to old age. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).