bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNAs as novel peripheral markers for suicidality in patients with major depressive disorder
Authors: Stapel Britta , Xiao Ke , Gorinski Nataliya , Schmidt Kevin , Pfanne Angelika , Fiedler Jan , Richter Imke , Vollbrecht Anna-Lena , Thum Thomas , Kahl Kai G. , Ponimaskin Evgeni 
Published: November 2022

ObjectiveMajor depressive disorder (MDD) constitutes a main risk factor for suicide. Suicide risk in psychiatric patients is primarily determined by often unreliable, self-reported information. We assessed serum levels of three microRNAs (miRNAs), previously demonstrated to be dysregulated in post-mortem brain samples of suicide victims, as potential peripheral biomarkers for suicidality.MethodsAll study participants were diagnosed with MDD according to Diagnostic and Statistical Manual of Mental Disorders, 5th edition criteria. Suicidality, defined as acute suicide risk or suicide attempt within one week prior to study entry, was assessed by clinical interview. Relative serum levels of miR-30a, miR-30e, and miR-200a, normalized to U6, were measured by quantitative real-time PCR in MDD inpatients with (MDD/SI, N = 19) and without (MDD, N = 31) acute suicide risk. Median age and gender distribution were comparable in both groups.ResultsLevels of miR-30a, miR-30e, and miR-200a were significantly elevated in MDD/SI compared to MDD. Subgroup analysis of the MDD/SI group showed that levels of miR-30e and miR-200a were significantly higher and miR-30a was increased by trend in patients admitted following a suicide attempt (N = 7) compared to patients with acute suicide risk but without recent suicide attempt (N = 12). Additionally, use of two databases for in silico transcription factor–miRNA interaction prediction indicated early growth response protein (EGR) 1 as potential transcriptional regulator for all three miRNAs.ConclusionThis study demonstrates suicide risk in MDD patients to be associated with increased levels of miR-30a, miR-30e, and miR-200a. Thus, these miRNAs might constitute potential biomarkers to predict suicidal behavior in MDD patients.
Current alcohol, tobacco, and khat use and associated factors among adults living in Harari regional state, eastern Ethiopia: A community-based cross-sectional study
Authors: Bete Tilahun , Lami Magarsa , Negash Abraham , Eyeberu Addis , Birhanu Abdi , Berhanu Bekelu , Abdeta Tilahun , Nigussie Shambel , Dechasa Deribe Bekele , Gemechu Kabtamu , Wedaje Dawud , Alemu Ayichew , Kibret Haregeweyn , Bayu Kefelegn , Meseret Fentahun , Abinew Yideg , Wondimneh Fenta , Dirirsa Gebisa , Godana Abduro , Husen Jemal , Alemu Addisu , Nigussie Kabtamu , Heluf Helina , Bogale Kasahun , Dessie Yadeta 
Published: November 2022

BackgroundPsychoactive substance use becomes a major public health and socioeconomic problem worldwide. Despite its burden and consequences, there is no community-based study conducted on psychoactive substance use and associated factors in eastern Ethiopia. Therefore, this study aimed to assess the magnitude and determinants of current alcohol, tobacco, and khat among adults living in Harari regional state, eastern Ethiopia.MethodsA community-based cross-sectional study was conducted on 955 adults living in Harari regional state. Participants were randomly recruited using a simple random sampling technique. Data were collected by interviewer-administered structured and semi-structured questionnaires. Data were entered into Epi Data version 3.1 and exported to Stata version 14.0 for analysis. Logistic regression analysis was performed to determine the association between the outcome and independent variables, and the statistical significance was declared at a p &lt; 0.5.ResultsOf 955 eligible participants, 95.29% participated in the study. The overall prevalence of current alcohol use, tobacco use, and khat use in this study was 8.24, 14.5, and 63.30%, respectively. The availability of alcohol, being unemployed, and being a current khat user were significantly associated with current alcohol use. Being male, having a low level of education, having peer pressure, having a common mental disorder, being a current alcohol user, and being a khat user were identified as significant predictors for current tobacco use. The age between 31 and 40 years, being a Muslim religion follower, being a farmer, being a current tobacco user, and availability of khat were significantly associated with current khat use.Conclusion and recommendationsThe prevalence of psychoactive substance use in the study area was relatively high compared with that of previous studies. By considering these determinants, screening, early identification, and developing appropriate intervention strategies to prevent and tackle current alcohol, tobacco, and khat use in the community should be of great concern.
Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid
Authors: Widatalla Namareq , Khandoker Ahsan , Yoshida Chihiro , Nakanishi Kana , Fukase Miyabi , Suzuki Arisa , Saito Masatoshi , Kimura Yoshitaka , Kasahara Yoshiyuki 
Published: November 2022

IntroductionAutism spectrum disorder (ASD) is considered a significant behavioral problem that is characterized by impairment in social interaction and communication. It is believed that some cases of ASD originate in the intrauterine maternal environment. Therefore, we hypothesized that there might be qualitative changes in the interaction between the mother and fetus in ASD during the prenatal period, hence, we investigated the similarity patterns between maternal and fetal heart rate (HR).MethodsIn this study, we first demonstrate the presence and formation of similarities between maternal and fetal RR interval (RRI) collected from typical developmental mice at different embryonic days (EDs), ED13.5, ED15.5, ED17.5, and ED18.5. The similarities were quantified by means of cross-correlation (CC) and magnitude-squared coherence (MSC) analyses. Correlation analysis between the CC coefficients and EDs and between MSC coefficients and EDs showed that the same coefficients increase with EDs, suggesting that similarities between maternal and fetal RRI are associated with typical fetal development. Next, because maternal and fetal similarities were indicative of development, a comparison analysis between the autism mouse model (injected with valproic acid (VPA)), and the control group (injected with saline) was performed for ED15.5 and ED18.5.ResultsThe results of the comparison showed that the CC and MSC coefficients of VPA fetuses were significantly lower than that of the control group. The lower coefficients in VPA-treated mice suggest that they could be one of the features of ASD symptoms. The findings of this study can assist in identifying potential ASD causes during the prenatal period.
Introduction of a bone-centered three-dimensional coordinate system enables computed tomographic canine femoral angle measurements independent of positioning
Authors: Brühschwein Andreas , Schmitz Bronson , Zöllner Martin , Reese Sven , Meyer-Lindenberg Andrea 
Published: November 2022

IntroductionMeasurement of torsional deformities and varus alignment in the canine femur is clinically and surgically important but difficult. Computed tomography (CT) generates true three-dimensional (3D) information and is used to overcome the limitations of radiography. The 3D CT images can be rotated freely, but the final view for angle measurements remains a subjective variable decision, especially in severe and complex angular and torsional deformities. The aim of this study was the development of a technique to measure femoral angles in a truly three-dimensional way, independent of femoral positioning.MethodsTo be able to set reference points in any image and at arbitrary positions of the CT series, the 3D coordinates of the reference points were used for mathematical calculation of the angle measurements using the 3D medical imaging Software VoXim®. Anatomical reference points were described in multiplanar reconstructions and volume rendering CT. A 3D bone-centered coordinate system was introduced and aligned with the anatomical planes of the femur. For torsion angle measurements, the transverse projection plane was mathematically defined by orthogonality to the longitudinal diaphyseal axis. For varus angle measurements, the dorsal plane was defined by a femoral retrocondylar axis. Independence positioning was tested by comparison of angle measurement results in repeated scans of 13 femur bones in different parallel and two double oblique (15/45°) positions in the gantry. Femoralvarus (or valgus), neck version (torsion), and inclination angles were measured, each in two variations.ResultsResulting mean differences ranged between –0.9° and 1.3° for all six determined types of angles and in a difference of &lt;1° for 17 out of 18 comparisons by subtraction of the mean angles between different positions, with one outlier of 1.3°. Intra- and inter-observer agreements determined by repeated measurements resulted in coefficients of variation for repeated measurements between 0.2 and 13.5%.DiscussionThe introduction of a bone-centered 3D coordinate system and mathematical definition of projection planes enabled 3D CT measurements of canine femoral varus and neck version and inclination angles. Agreement between angular measurements results of bones scanned in different positions on the CT table demonstrated that the technique is independent of femoral positioning.
Inhibition of Phytopathogenic and Beneficial Fungi Applying Silver Nanoparticles In Vitro
Authors: Vera-Reyes Ileana , Altamirano-Hernández Josué , Reyes-de la Cruz Homero , Granados-Echegoyen Carlos A. , Loera-Alvarado Gerardo , López-López Abimael , Garcia-Cerda Luis A. , Loera-Alvarado Esperanza 
Published: November 2022

In the current research, our work measured the effect of silver nanoparticles (AgNP) synthesized from Larrea tridentata (Sessé and Moc. ex DC.) on the mycelial growth and morphological changes in mycelia from different phytopathogenic and beneficial fungi. The assessment was conducted in Petri dishes, with Potato-Dextrose-Agar (PDA) as the culture medium; the AgNP concentrations used were 0, 60, 90, and 120 ppm. Alternaria solani and Botrytis cinerea showed the maximum growth inhibition at 60 ppm (70.76% and 51.75%). Likewise, Macrophomina spp. required 120 ppm of AgNP to achieve 65.43%, while Fusarium oxisporum was less susceptible, reaching an inhibition of 39.04% at the same concentration. The effect of silver nanoparticles was inconspicuous in Pestalotia spp., Colletotrichum gloesporoides, Phytophthora cinnamomi, Beauveria bassiana, Metarhizium anisopliae, and Trichoderma viridae fungi. The changes observed in the morphology of the fungi treated with nanoparticles were loss of definition, turgidity, and constriction sites that cause aggregations of mycelium, dispersion of spores, and reduced mycelium growth. AgNP could be a sustainable alternative to managing diseases caused by Alternaria solani and Macrophomina spp.
Aplicação da tinta inseticida um estudo de caso na Escola Municipal CMEI Ailton Roth
Authors: Silva Cayon Ithalo Ferreira da , Pacheco Maria dos Anjos Fernandes , Pinheiro Érika Cristina Nogueira Marques 
Published: November 2022

A indústria da construção civil desempenha um papel de grande relevância na sociedade brasileira, mediante a tal importância, derivou-se a necessidade em realizar investimentos em tintas para o combate a enfermidades endêmicas. As tintas são materiais geralmente líquidos ou em pó solúvel, constituído de veículo, pigmentos, solventes e aditivos. Os aditivos são, geralmente, produtos químicos sofisticados, com alto grau de eficiência, capazes de modificar, significativamente, as propriedades da tinta. A Combartpaint 10, foi desenvolvida na Espanha pela cientista Maria Pilar Mateo Herrero, consiste em uma tinta com microcápsulas inseticidas de biopolímero que são liberadas gradualmente após a aplicação na parede. O presente trabalho tem como objetivo apresentar de forma clara e precisa as etapas da aplicação da tinta inseticida, através de um estudo de caso na Escola Municipal CMEI Ailton Roth, localizada no município de Manaus-AM. Como metodologia adotou-se a pesquisa exploratória e qualitativa. Por fim através dos resultados obtidos, foi possível identificar, mediante ao estudo de aplicação e análise das tintas inseticidas, obtendo o conhecimento da aplicabilidade de forma correta, bem como sua reologia, desempenho da tinta e comportamento de escorrimento, dessa forma comprovando a eficácia da tinta inseticida.
Influência da pandemia sobre a qualidade de vida dos idosos
Authors: Bonini Luci Mendes de Melo , Panhoca Ivone , Gonçalves Priscilla Gabriela Rodrigues , Imada Gustavo Yuiti Inoue , Watanabe Fabiana Yumi , Canavarros João Victor Oliveira , Hong Daniel José , Neves Sibele Faria 
Published: November 2022

As projeções demográficas tornam cada vez mais evidente o crescente envelhecimento da população brasileira. Diante desse quadro e da pandemia, é natural que as autoridades públicas e a sociedade, como um todo, comecem a ter uma maior preocupação com a qualidade de vida das pessoas com idade mais avançada. Por meio deste trabalho esperou-se avaliar a influência da pandemia sobre a qualidade de vida dos idosos, a alteração ou manutenção dos exercícios físicos durante este período nos grupos ativos e sedentários, bem como identificar os fatores que motivaram sua permanência regularmente e as principais barreiras que dificultaram a adesão no grupo sedentário. Este estudo é de natureza exploratório-descritiva, transversal e de abordagem quanti-qualitativa. Os dados foram coletados e analisados por meio do questionário SF-36 e outro socioeconômico, elaborado pelo próprio grupo de pesquisa e também pela análise estatística por meio dos métodos Shapiro-Wilk e Wilcoxon. No quesito Qualidade de Vida, as pontuação dos domínios AE, CF e LAF reduziram comparativamente a antes e durante a pandemia. No grupo ativo, 16,3% relataram ter reduzido a frequência com que praticavam suas atividades. Já o grupo sedentário (28,6%) continuou a não praticar exercícios físicos. Os idosos sedentários justificaram o desânimo e a falta de coragem (16%) como principais fatores dificultadores à adesão. Portanto, alguns aspectos da qualidade de vida dos idosos piorou durante a pandemia. Houve redução na frequência na prática de atividades físicas entre o grupo ativo, sendo que o grupo sedentário permaneceu na mesma condição.
Agenda 2030 e a carta da terra como ferramenta para a educação ambiental e mobilização social
Authors: Birolo Alesandra Bez , Carvalho Junior Oldemar de Oliveira 
Published: November 2022

A Agenda 2030, enquanto um plano de ação global, assumido pelo Brasil e mais 192 países para efetivar os direitos humanos e para promover o desenvolvimento sustentável, ainda é pouca conhecida e trabalhada no processo de formação docente, bem como a Carta da Terra, outro tratado importante que este ano fez 21 anos. O presente trabalho avaliou o grau de engajamento no ensino fundamental final II, frente a Agenda 2030 e a Carta da Terra, utilizando o tema mudança climática, por um modelo de questionário que compreende cinco fatores: conhecimento, atitude, preocupação, responsabilidade e atividade. Como tornar estes tratados internacionais aplicáveis nas salas de aula e qual o nível de engajamento dos alunos de Ciências do Ensino Fundamental Final II possuem com o tema proposto? A educomunicação foi usada como fundamentação teórica para entender o processo de formação dos alunos. As aulas aconteceram via agendamentos das escolas. O questionário foi aplicado dentro de uma instituição do terceiro setor, Instituto Ekko Brasil (IEB), que trabalha com um programa ambiental denominado PAIE (Programa de Atendimento as Instituições de Ensino, Pesquisa e Extensão). No total, 45 questionários foram preenchidos e validados. Destes, 27 foram preenchidos por estudantes do gênero feminino, entre 12 e 14 anos, e 18 do gênero masculino, de 13 a 15 anos. Os dados obtidos indicam que 98% dos estudantes desconhecem a Agenda 2030 e a Carta da Terra e 77% afirmam que não é de sua responsabilidade agir de forma favorável ao clima. Os dados foram disponibilizados pelo IEB, que tratou do tema com estudantes da rede pública e privada de ensino da Grande Florianópolis na forma de aulas assíncronas, no espaço educomunicativo, mantido dentro do Centro de Pesquisa da Instituição.
Multi-key Fully Homomorphic Encryption without CRS from RLWE
Authors: Luo Fucai 
Published: November 2022

<p>Fully Homomorphic Encryption (FHE) is a powerful encryption system in cloud computing that allows homomorphic computations on encrypted data without decrypting them. Multi-key fully homomorphic encryption (MFHE), as an extension to FHE, allows homomorphic computations on ciphertexts encrypted under different keys. However, most MFHE schemes require a Common Random\slash Reference String (CRS), while the few that do not are based on the Learning With Errors (LWE) problem, which means that they can only deal with single bit plaintext. Consequently, MFHE schemes based on the Ring Learning With Errors (RLWE) problem are more desirable, as they can handle polynomial plaintext. Requiring the CRS seems to weaken the semantic definition of MFHE, where all users generate their own keys independently.</p>
<p>In this paper, we study the RLWE-based MFHE in the CRS model and propose the first RLWE-based MFHE without CRS. To this end, we remove the CRS by designing a new relinearization algorithm. Like previous MFHE schemes, our RLWE-based MFHE without CRS has a simple 1-round threshold decryption, which implies a $3$-round secure MPC protocol in the plain model from the RLWE assumption.</p>
Fratura De Fêmur Proximal Na Criança
Authors: Tescarolli Arthur , Kato Karen Mayuri , Maruoka Rafael Krawczun , Buainain Ronaldo Parissi , Ninomya André Felipe , Nonose Nilson 
Published: November 2022

Introdução: As fraturas do colo do fêmur nas crianças são raras, correspondendo à cerca de 1% das fraturas na infância. Objetivo: Descrever uma série de dez pacientes com fratura do fêmur proximal, tratados no período entre 2011 a 2022, relacionando o mecanismo de trauma, o tipo da fratura, sua forma de tratamento e a evolução para possíveis complicações.
Métodos: Realizado um estudo retrospectivo, com idade variando entre zero a dezesseis anos, não sendo incluídas fraturas patológicas no estudo, sendo cada fratura classificada por Delbet.
Resultados: O índice total de complicações atingiu 50%. A média de idade foi 8,9 anos, sendo ambos os lados igualmente afetados. Fraturas do tipo II por Delbet foram as mais encontradas, seguidas tipo III e menor frequência a do tipo I e IV. As complicações evidenciadas foram necrose avascular da cabeça, dismetria, pseudoartrose, fechamento prematuro da fise e perda da redução com necessidade de reabordagem. Conclusão: Os autores chamam à atenção para a raridade das fraturas, porém, com alto índice de complicações.
ENGINEERING THE NaYF4:Yb3+/Tm3+ UPCONVERSION NANOPARTICLE LUMINESCENCE ENERGY TRANSFER FOR A RATIOMETRIC pH INDICATOR
Authors: Nguyen Nhat Nam 
Published: November 2022

Fluorescent dye 8-hydroxypyrene-1,3,6-trisulfonic acid (HPTS) is used to develop a ratiometric pH indicator based on NaYF4:Yb3+/Tm3+ upconversion nanoparticles (UCNPs). HPTS was functionalized onto the UCNP surfaces via a modified co-condensation silica coating (UCNP@SiO2-HPTS). The as-prepared UCNP@SiO2-HPTS core-shell nanostructure was characterized with transmission electron microscopy, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), and photoluminescence spectroscopy. Luminescence resonance energy transfer (LRET) from NaYF4:Yb3+/Tm3+ UCNP to HPTS was found to exhibit pH-sensitivity simultaneously under near-infrared (NIR) irradiation (λ = 980 nm).
All models are wrong, but are they useful? Assessing reliability across multiple sites to build trust in urban drainage modelling
Authors: Pedersen Agnethe Nedergaard , Brink-Kjær Annette , Mikkelsen Peter Steen 
Published: November 2022

Abstract. Simulation models are widely used in urban drainage engineering and research, but they are known to include errors and uncertainties that are not yet fully realised. Within the herein developed framework, we investigate model adequacy across multiple sites by comparing model results with measurements for three model objectives, namely surcharges (water level rises above defined critical levels related to basement flooding), overflows (water levels rise above a crest level), and everyday events (water levels stay below the top of pipes). We use
multi-event hydrological signatures, i.e. metrics that extract specific
characteristics of time series events in order to compare model results with the observations for the mentioned objectives through categorical and
statistical data analyses. Furthermore, we assess the events with respect to sufficient or insufficient categorical performance and good, acceptable, or poor statistical performance. We also develop a method to reduce the
weighting of individual events in the analyses, in order to acknowledge
uncertainty in model and/or measurements in cases where the model is not
expected to fully replicate the measurements. A case study including several years of water level measurements from 23 sites in two different areas shows that only few sites score a sufficient categorical performance in relation to the objective overflow and that sites do not necessarily
obtain good performance scores for all the analysed objectives. The
developed framework, however, highlights that it is possible to identify
objectives and sites for which the model is reliable, and we also suggest
methods for assessing where the model is less reliable and needs further
improvement, which may be further refined in the future.