bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of streptococcal infection in the etiopathogenesis of pityriasis lichenoides chronica and the therapeutic efficacy of azithromycin: a randomized controlled trial
Authors: Elbendary Amira , Youssef Randa , Abdel-Halim Mona R. E. , Abdel Halim Dalia , El Sharkawy Dina Ahmed , Alfishawy Mostafa , Gad Maha A. , Gad Abdallah , Elmasry Maha Fathy 
Published: September 2022

AbstractThe exact aetiology of pityriasis lichenoides chronica (PLC) remains unknown. While phototherapy is the most investigated therapeutic modality, azithromycin has been used scarcely. The aim of this study is to evaluate the therapeutic efficacy of azithromycin in the treatment of PLC compared to NB-UVB and evaluating the presence of streptococcal infection as a possible etiological factor in PLC patients. The study was designed as a randomised controlled trial. Twenty-four patients with PLC were randomly allocated into either azithromycin (n = 13, standard dose every 10 days) or NB-UVB (n = 11, thrice weekly) groups. End of study (EOS) was either complete clearance of lesions or a maximum of 8 weeks. Therapeutic efficacy was defined as percent reduction in lesions and was calculated for the rash as a whole, erythematous papules alone, and hypopigmented lesions alone and graded into complete, very-good, good, poor or no response. Anti-streptolysin O titre (ASOT), anti-deoxyribonuclease B titre (anti-DNaseB) and throat culture were evaluated at day 0. No significant difference existed between both groups as regards therapeutic efficacy. At EOS, NB-UVB achieved significantly more percent reduction in the extent of hypopigmented lesions and consequently in the rash as a whole (p = 0.001, p = 0.034, respectively). The extent of the rash as a whole was significantly less in the NB-UVB at EOS (p = 0.029, respectively). The effect of NB-UVB on hypopigmented lesions appeared early at week 4 of treatment. Only two patients, one from each group, relapsed during the 3 month follow-up. Evidence of recent streptococcal infection was present in 79% of the cases, mainly in the form of elevated ASOT (94.7%). It was significantly more encountered in young children (< 13 years) (p = 0.03) and was associated with more extent of erythematous papules and consequently with more extent of the rash as a whole (p = 0.05 and p = 0.01, respectively). It did not affect outcome of therapy at EOS. Azithromycin did not show more favorable response in patients with recent streptococcal infection. Therapeutic efficacy of azithromycin is comparable to NB-UVB in treatment of PLC; however, NB-UVB is superior in management of hypopigmented lesions. It is highly suggested that PLC could be a post streptococcal immune mediated disorder.Registration number: ClinicalTrials.gov, NCT03831269.
Depression and anxiety in women with malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST): an analysis of the AGO-CORSETT database
Authors: Bossart M. , Plett H. , Krämer B. , Braicu E. , Czogalla B. , Klar M. , Singer S. , Mayr D. , Staebler A. , du Bois A. , Kommoss S. , Link T. , Burges A. , Heitz F. , Grube M. , Trillsch F. , Harter P. , Wimberger P. , Buderath P. , Hasenburg A. 
Published: September 2022

Abstract
Introduction
The intention of this study was to evaluate the level of anxiety and depression of malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) survivors and to identify possible alterable cofactors.

Methods
CORSETT was an observational, multicenter, mixed retrospective/prospective cohort study of the AGO Studygroup. Women who had been diagnosed with MOGCTs and SCSTs between 2001 and 2011 were asked to complete the Hospital Anxiety and Depression Scale (HADS) to evaluate distress. Predictors of distress (type of surgery, chemotherapy, time since diagnosis, recurrence, second tumor, pain) were investigated using multivariate linear regression analysis.

Results
150 MOGCT and SCST patients with confirmed histological diagnosis completed the questionnaire median seven years after diagnosis. They had a HADS total score ≥ 13 indicating severe mental distress in 34% of cases. Patients after fertility-conserving surgery had lower probability of severe mental distress than those without fertility-conserving treatment (β = − 3.1, p = 0.04). Pain was associated with the level of distress in uni- and multivariate analysis (coef 0.1, p < 0.01, coef. Beta 0.5).

Discussion
Severe mental distress was frequent in patients with MOGCT and SCST and the level of pain was associated with the level of distress. Fertility conserving therapy, however, was associated with less mental distress. Screening and treatment of pain and depression is required to improve mental well-being in survivors of MOGCT and SCST.
Menstrual cycle affects iron homeostasis and hepcidin following interval running exercise in endurance-trained women
Authors: Alfaro-Magallanes Víctor M. , Barba-Moreno Laura , Romero-Parra Nuria , Rael Beatriz , Benito Pedro J. , Swinkels Dorine W. , Laarakkers Coby M. , Díaz Ángel E. , Peinado Ana B. ,   the IronFEMME Study Group
Published: September 2022

Abstract
Purpose
Menstrual cycle phase affects resting hepcidin levels, but such effects on the hepcidin response to exercise are still unclear. Thus, we investigated the hepcidin response to running during three different menstrual cycle phases.

Methods
Twenty-one endurance-trained eumenorrheic women performed three identical interval running protocols during the early-follicular phase (EFP), late-follicular phase (LFP), and mid-luteal phase (MLP). The protocol consisted of 8 × 3 min bouts at 85% of the maximal aerobic speed, with 90-s recovery. Blood samples were collected pre-exercise and at 0 h, 3 h and 24 h post-exercise.

Results
Data presented as mean ± SD. Ferritin were lower in the EFP than the LFP (34.82 ± 16.44 vs 40.90 ± 23.91 ng/ml, p = 0.003), while iron and transferrin saturation were lower during the EFP (58.04 ± 19.70 µg/dl, 14.71 ± 5.47%) compared to the LFP (88.67 ± 36.38 µg/dl, 22.22 ± 9.54%; p < 0.001) and the MLP (80.20 ± 42.05 µg/dl, 19.87 ± 10.37%; p = 0.024 and p = 0.045, respectively). Hepcidin was not affected by menstrual cycle (p = 0.052) or menstrual cycle*time interaction (p = 0.075). However, when comparing hepcidin at 3 h post-exercise, a moderate and meaningful effect size showed that hepcidin was higher in the LFP compared to the EFP (3.01 ± 4.16 vs 1.26 ± 1.25 nMol/l; d = 0.57, CI = 0.07–1.08). No effect of time on hepcidin during the EFP was found either (p = 0.426).

Conclusion
The decrease in iron, ferritin and TSAT levels during the EFP may mislead the determination of iron status in eumenorrheic athletes. However, although the hepcidin response to exercise appears to be reduced in the EFP, it shows no clear differences between the phases of the menstrual cycle (clinicaltrials.gov: NCT04458662).
Regularized online tensor factorization for sparse knowledge graph embeddings
Authors: Zulaika Unai , Almeida Aitor , López-de-Ipiña Diego 
Published: September 2022

AbstractKnowledge Graphs represent real-world facts and are used in several applications; however, they are often incomplete and have many missing facts. Link prediction is the task of completing these missing facts from existing ones. Embedding models based on Tensor Factorization attain state-of-the-art results in link prediction. Nevertheless, the embeddings they produce can not be easily interpreted. Inspired by previous work on word embeddings, we propose inducing sparsity in the bilinear tensor factorization model, RESCAL, to build interpretable Knowledge Graph embeddings. To overcome the difficulties that stochastic gradient descent has when producing sparse solutions, we add $$l_1$$

l
1

regularization to the learning objective by using the generalized Regularized Dual Averaging online optimization algorithm. The proposed method substantially improves the interpretability of the learned embeddings while maintaining competitive performance in the standard metrics.
Fluorescence perfusion assessment of vascular ligation during ileal pouch-anal anastomosis
Authors: Slooter M. D. , van der Does de Willebois E. M. L. , Joosten J. J. , Reijntjes M. A. , Buskens C. J. , Tanis P. J. , Bemelman W. A. , Hompes R. 
Published: September 2022

AbstractBackgroundIntraoperative fluorescence angiography (FA) is of potential added value during ileal pouch-anal anastomosis (IPAA), especially after vascular ligation as part of lengthening measures. In this study, time to fluorescent enhancement during FA was evaluated in patients with or without vascular ligation during IPAA.MethodsThis is a retrospective cohort study of all consecutive patients that underwent FA-guided IPAA between August 2018 and December 2019 in our tertiary referral centre. Vascular ligation was defined as disruption of the ileocolic arcade or ligation of interconnecting terminal ileal branches. FA was performed before and after ileoanal anastomotic reconstruction. During FA, time to fluorescent enhancement was recorded at different sites of the pouch.ResultsThirty-eight patients [55.3% male, median age 45 years (IQR 24–51 years)] were included, of whom the majority (89.5%) underwent a modified-2-stage restorative proctocolectomy. Vascular ligation was performed in 15 patients (39.5%), and concerned central ligation of the ileocolic arcade in 3 cases, interconnecting branches in 10, and a combination in 2. For the entire cohort, time between indocyanine green (ICG) injection and first fluorescent signal in the pouch was 20 s (IQR 15–31 s) before and 25 s (IQR 20–36 s) after anal anastomotic reconstruction. Time from ICG injection to the first fluorescent signal at the inlet, anvil and blind loop of the pouch were non-significantly prolonged in patients that received vascular ligation.ConclusionsResults from this study indicate that time to fluorescence enhancement during FA might be prolonged due to arterial rerouting through the arcade or venous outflow obstruction in case of vascular ligation.
Margins matter: the importance of field margins as avian brood-rearing habitat in an intensive agricultural landscape
Authors: Krüger Heidi , Jaatinen Kim , Holopainen Sari , Niemi Milla , Vehkaoja Mia , Virtanen Juha , Väänänen Veli-Matti , Nummi Petri 
Published: September 2022

AbstractAgricultural intensification has significantly impacted habitat structures in agricultural landscapes and is one of the main drivers of biodiversity decline, especially in farmland birds. Birds are considered to reflect well the trends in other biodiversity elements and are therefore often used as indicator species. We studied common pheasant (Phasianus colchicus) brood habitat use in a small-grain-dominated farmland in southern Finland. The broods significantly preferred field margins compared to their availability. The importance of field margins was underlined, as 68% of pheasant brood observations in grain fields were within a 25-m-wide zone from the field edge, despite the availability being only 40% of the field area. Our results support the idea that field margins and their proximity act as possible biodiversity reservoirs even in intensive farming systems. Increasing the amount of field margins can be an effective management method when aiming to improve success of common pheasant broods while simultaneously benefitting farmland biodiversity. Identifying key habitats and landscape features that allow the co-existence of biodiversity and effective food production is crucial when aiming to halt the ongoing biodiversity collapse.
Short mindfulness meditation training: does it really reduce perceived stress?
Authors: Horrillo Álvarez Barbara , Marín Martín Carolina , Rodríguez Abuín Manuel , Orio Ortiz Laura 
Published: September 2022

AbstractTo study whether an 8-week mindfulness meditation training program truly reduces perceived stress without designing a stress reduction program. An experimental study was performed in which we studied the effects of 8 weeks of MM training on attention and awareness, as measured by the MAAS (mindfulness attention awareness scale) and perceived stress, as measured by the PSQ (perceived stress questionnaire), in 80 volunteers from the general public recruited by email from university centers. An increase in the individual’s dispositional capacity to be attentive and aware of the experience of the present moment in everyday life was observed in the experimental group versus the control group; F (2, 156) = 14.30, p = .000, η2 partial = .155. Perceived stress showed no significant differences between groups in: social acceptance; F (2, 156) = 2.30, p = .103, overload; F (2, 156) = 2.32, p = .101, irritability, tension and fatigue; F (2, 156) = 2.27, p = .106, energy and joy; F (2, 156) = 2.79, p = .065. MM practice for 8 weeks of training increases the individual’s dispositional capacity to be attentive and aware of the experience of the present moment in everyday life but may not reduce perceived stress.
Age and gender relations on LinkedIn pages of global staffing agencies
Authors: Xu Wenqian , Previtali Federica 
Published: September 2022

AbstractThis study investigates the ways in which age and gender play out on the LinkedIn pages of global staffing agencies through an intersectionality lens. A discourse analysis of 437 LinkedIn posts (including visual images, captions, and comments) was conducted. This study found that the corporate discourse of diversity shaped the ways that age and gender were represented. The portrayals of age and gender were found to create gendered specializations of labor and reproduce gender stereotypes; additionally, some workers were represented as disembodied clusters of attributes. The results of this study show the complex ways in which age and gender systems unfold, including two systems mutually reinforcing, gender/age system surfacing, and two systems dissolving. The findings suggest that diversity has lost its performativity as a concept, as its portrayals may not support disadvantaged groups gaining access to better employment opportunities. This study proposes that staffing agencies actively address intersectional disadvantages and foster a gender- and age-transformative change.
Adaptation of Fibril-Reinforced Poroviscoelastic Properties in Rabbit Collateral Ligaments 8 Weeks After Anterior Cruciate Ligament Transection
Authors: Orozco Gustavo A. , Ristaniemi Aapo , Haghighatnejad Mehrnoush , Mohammadi Ali , Finnilä Mikko A. J. , Saarakkala Simo , Herzog Walter , Isaksson Hanna , Korhonen Rami K. 
Published: September 2022

AbstractLigaments of the knee provide stability and prevent excessive motions of the joint. Rupture of the anterior cruciate ligament (ACL), a common sports injury, results in an altered loading environment for other tissues in the joint, likely leading to their mechanical adaptation. In the collateral ligaments, the patterns and mechanisms of biomechanical adaptation following ACL transection (ACLT) remain unknown. We aimed to characterize the adaptation of elastic and viscoelastic properties of the lateral and medial collateral ligaments eight weeks after ACLT. Unilateral ACLT was performed in six rabbits, and collateral ligaments were harvested from transected and contralateral knee joints after eight weeks, and from an intact control group (eight knees from four animals). The cross-sectional areas were measured with micro-computed tomography. Stepwise tensile stress-relaxation testing was conducted up to 6% final strain, and the elastic and viscoelastic properties were characterized with a fibril-reinforced poroviscoelastic material model. We found that the cross-sectional area of the collateral ligaments in the ACL transected knees increased, the nonlinear elastic collagen network modulus of the LCL decreased, and the amount of fast relaxation in the MCL decreased. Our results indicate that rupture of the ACL leads to an early adaptation of the elastic and viscoelastic properties of the collagen fibrillar network in the collateral ligaments. These adaptations may be important to consider when evaluating whole knee joint mechanics after ACL rupture, and the results aid in understanding the consequences of ACL rupture on other tissues.
Does NIH select the right healthcare ventures through the SBIR grant program?
Authors: Dutta Supradeep , Rodrigues Jenna , Folta Timothy B. 
Published: September 2022

AbstractOne way governments aim to spur entrepreneurship is through providing startup capital to qualified ventures. In the United States, the government does so through federal grant programs like the SBIR/STTR program. Despite the government’s efforts to spur entrepreneurship through capital distribution, we don’t know much about the selection capabilities that government agencies like the National Institutes of Health (NIH) have in place to choose qualified ventures for funding. Through exploiting a quasi-natural experiment enabled by the American Reinvestment and Recovery Act (ARRA) of 2009, we seek to determine whether the NIH selects ventures with the most innovation and commercialization potential. Overall, our findings suggest that the NIH effectively identifies and prioritizes ventures with superior observable innovation capabilities. Yet, they could do more to discern the underlying tacit value of the innovation to prioritize selecting high-risk ventures that have the potential to create impactful innovation in the future. Our analyses should help policymakers orient their thinking around selection capabilities when assessing the impact of government programs with the broader objective of supporting novel healthcare innovation.
The moving target tracking and segmentation method based on space-time fusion
Authors: Wang Jie , Xuan Shibin , Zhang Hao , Qin Xuyang 
Published: September 2022

AbstractAt present, the target tracking method based on the correlation operation mainly uses deep learning to extract spatial information from video frames and then performs correlations on this basis. However, it does not extract the motion features of tracking targets on the time axis, and thus tracked targets can be easily lost when occlusion occurs. To this end, a spatiotemporal motion target tracking model incorporating Kalman filtering is proposed with the aim of alleviating the problem of occlusion in the tracking process. In combination with the segmentation model, a suitable model is selected by scores to predict or detect the current state of the target. We use an elliptic fitting strategy to evaluate the bounding boxes online. Experiments demonstrate that our approach performs well and is stable in the face of multiple challenges (such as occlusion) on the VOT2016 and VOT2018 datasets with guaranteed real-time algorithm performance.
Phase plane analysis applied to non-explicit multibody vehicle models
Authors: Mantaras Daniel A. , Luque Pablo , Alonso Marta 
Published: September 2022

AbstractA new methodology for constructing stability maps (phase-plane analysis) is presented and validated for application to complex multibody vehicle models implemented in Multibody Dynamics simulation software (Adams®). Traditional methodologies are developed to be applied to explicit mathematical models. Given the complexity of some special multibody systems, particularly in vehicle dynamics, simplifications are needed to apply this stability analysis technique. The main limitation when using simplified models is the need to neglect components which could have a significant influence on the dynamic behavior of the system and therefore on its stability. In the proposed methodology it is not necessary to have access to explicit mathematical models of multibody systems. Thus, the stability map of a vehicle model can be constructed by considering highly nonlinear dynamic elements, such as tires and silent-blocks components, modeled using the nonlinear finite element technique.
Dual disorder-driven magnetic dynamics in GdCu2 superantiferromagnetic nanoparticles
Authors: Jefremovas Elizabeth M , Svedlindh Peter , Barquín Luis Fernández 
Published: September 2022

AbstractThe spin dynamics in magnetically disordered GdCu2 nanoparticles, varying the nanoparticle size in the range 53 to 7 nm, has been scrutinized. Dynamic χAC susceptibility measurements have revealed the existence of dissipation at Tg = 18 K, which is associated to the spin freezing transition, for all the ensembles. Besides, the superantiferromagnetic ensembles (〈D〉≥ 24 nm) also showcase a dissipation contribution close to the vicinity of the Néel transition, TN = 40.2 K. This dissipation, which takes the form of two humps located at Td1 = 33.5(5) K and Td2 = 40.0(5) K, is associated to uncompensated antiferromagnetic moments. Time-dependent phenomena (ageing and memory effects) are only evidenced below the spin freezing transition, evidencing that solely this low-temperature disordered phase is driven by the frustration of RKKY exchange interactions. Consequently, GdCu2 nanoparticles display a dual disorder-driven magnetic dynamics, which are the one ascribed to the magnetically frustrated moments located at the nanoparticle surface; and that of uncompensated antiferromagnetic moments located within the nanoparticle core.
Climate-risk materiality and firm risk
Authors: Matsumura Ella Mae , Prakash Rachna , Vera-Muñoz Sandra C. 
Published: September 2022

AbstractManagers are required to disclose material climate risk in Form 10-K, but their decision whether or not to disclose is confounded by the lack of consensus on whether climate risk is material to the firms, as well as uncertainty about enforcement of disclosure regulations. Using the SASB Materiality Map™ to proxy for market expectations of climate risk materiality, we test whether the association between disclosing climate risk in 10-Ks and firm risk (proxied by cost of equity (COE)) varies with market expectations of climate risk materiality. Using S&P 500 firms’ decisions whether to disclose climate risk in Form 10-K for 2008 to 2016, we find that disclosing firms’ COE is 27 bps lower than nondisclosing firms’ COE. In industries where the market expects climate risk to be material, disclosing firms’ COE is 50 bps lower than nondisclosing firms’, while in industries where the market does not expect climate risk to be material, disclosing firms’ COE is 23 bps lower than nondisclosing firms’. Our results indicate that markets use expectations of climate risk materiality to infer the credibility of managers’ climate risk disclosure decisions. Our research contributes to policy-making on climate risk disclosures in regulatory filings and informs the debate around the costs and benefits of the SEC’s current proposal to enhance climate risk disclosures.
Children’s Physical Gender Schemas: Acquisition and Features
Authors: Hill Darryl B. , Tenenbaum Harriet R. 
Published: September 2022

AbstractStudies on how physical gender schemas develop in children have traditionally utilized forced-choice and close-ended tasks, finding that the ability to make gender-related distinctions develops in the first years of a child’s life. To reduce demand characteristics that reinforce gender binaries in children’s models of gender, we relied on open-ended discourse analysis to study children’s physical gender schemas. We focused on whether children’s ability to ask questions that distinguish gender groups was greater in older than younger children. Participants were 44 3–4-year-olds, 35 5–6-year-olds, and 23 7–8-year-old children in the U.K. who were led through a guessing game to elicit gender-related beliefs and compare their beliefs about gender to their beliefs about other entities such as living things. When asking questions to distinguish gender binary groups, older children judging gendered individuals were more likely to ask questions that stereotypically distinguished the gender groups than younger children. Older children were also more likely to focus on individuals’ biological properties, clothing, and hair length than were younger children. Thus, the development of a child’s understanding of physical gender schemas gender is discrete, developing gradually at least until the age of 8.