bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multicenter Study of 2-year Outcomes Following Hyperthermia Therapy with Mitomycin C in Treating Non-Muscle Invasive Bladder Cancer: HIVEC-E
Authors: Tan Wei Phin , Plata Bello Ana , Garcia Alvarez Carlos , Guerrero-Ramos Félix , González-Padilla Daniel A. , Nzeh Cajetan , Manuel de la Morena Jose , de Torres Ignacio Gonzalez Valcarcel , Hendricksen Kees , Díaz Goizueta Francisco Javier , Del Álamo Julio Fernandez , Chiancone Francesco , Fedelini Paolo , Poggio Massimiliano , Porpiglia Francesco , Gonzalo Rodríguez Victoria C. , Torres Javier Montero , Wilby Daniel , Robinson Richard , Sousa-Escandón Alejandro , Mata Juan León , Pontones Moreno Jose L. , Molina Francisco Delgados , Adriazola Semino Miguel A. , Stemberger Andrew T. , Escudero Jesús Calleja , Redorta Joan Palou , Tan Wei Shen 
Published: September 2022

INTRODUCTION: High grade, non-muscle invasive bladder cancer (NMIBC) is usually treated with intravesical Bacillus Calmette–Guérin. Chemohyperthermia therapy (CHT) may be a novel alternative therapy for the treatment of NMIBC. OBJECTIVE: To evaluate the recurrence-free survival (RFS) of patients treated with CHT using the Combat bladder recirculation system (BRS) for NMIBC. METHODS: This was a prospective multi-institutional study of 1,028 consecutive patients with NMIBC undergoing CHT between 2012 and 2020. A total of 835 patients were treated with CHT with Mitomycin C (MMC). Disease was confirmed on transurethral resection of bladder tumor (TURBT) prior to starting CHT. Follow-up included cystoscopy and subsequent TURBT if recurrence/progression was suspected. The primary endpoint was RFS. Secondary endpoints were progression-free survival (PFS) and adverse events from CHT. RESULTS AND LIMITATIONS: Median follow up was 22.4 months (Interquartile range (IQR): 12.8 –35.8). Median age was 70.4 years (IQR: 62.1 –78.6). A total of 557 (66.7%), 172 (20.6) and 74 (8.9%) of patients were classified to BCG naïve, BCG unresponsive and BCG failure, respectively. The RFS at 12 months and 24 months for BCG naïve was 87.6% (95% CI 85.0% - 90.4%) and 75.0% (95% CI 71.3% - 78.8%), respectively. The RFS at 12 months and 24 months for BCG unresponsive cohort was 78.1% (95% CI 72.0% - 84.7%) and 57.4% (95% CI 49.7% - 66.3%), respectively. The RFS at 24 months for the BCG unresponsive cohort for CIS with/without papillary disease and papillary only disease were 43.6% (95% CI 31.4% –60.4%) and 64.5% (95% CI 55.4% - 75.1%), respectively. Minor adverse events occurred in 216 (25.6%) patients and severe events occurred in 17 (2.0%) patients. CONCLUSIONS: CHT with MMC using the Combat BRS is effective in the medium term and has a favorable adverse event profile.
Adjuvant Chemotherapy Plus Radiotherapy versus Chemotherapy Alone for Locally Advanced Bladder Cancer after Radical Cystectomy
Authors: Ernandez John , Kaul Sumedh , Fleishman Aaron , Korets Ruslan , Chang Peter , Wagner Andrew , Kim Simon , Bellmunt Joaquim , Kaplan Irving , Olumi Aria F. , Gershman Boris 
Published: September 2022

BACKGROUND: Survival with locally advanced bladder cancer (LABC) following radical cystectomy (RC) remains poor. Although adjuvant chemotherapy (AC) is standard of care, one small, randomized trial has suggested a potential survival benefit when combined with post-operative radiotherapy (PORT). OBJECTIVE: We examined the association of AC + PORT with overall survival (OS) in patients with LABC after RC. METHODS: Using a prior phase 2 trial to inform design, we conducted observational analyses to emulate a hypothetical target trial of patients aged 18–79 years with pT3-4 Nany M0 or pTany N1-3 M0 urothelial bladder carcinoma following RC who were treated with AC (multiagent chemotherapy within 3 months of RC) with or without PORT (≥45 Gy to the pelvis) from 2006–2015 in the NCDB. Patients who received preoperative chemotherapy or radiotherapy were excluded. The associations of treatment with OS were evaluated using multivariable Cox regression. RESULTS: 1,684 patients were included, with 66 receiving AC + PORT and 1,618 AC alone. Compared to patients treated with AC alone, those treated with AC + PORT were more likely to have pT4 disease (52% vs 26%; p < 0.01), positive surgical margins (44% vs 17%; p < 0.01), and be treated at a non-academic facility (75% vs 53%; p < 0.01). Crude 5-year OS was 19% for AC + PORT versus 36% for AC alone ( p = 0.01). Adjusted 5-year OS was 33% for AC + PORT versus 36% for AC alone ( p = 0.49). After adjusting for baseline characteristics including pathologic features, AC + PORT was not associated with improved OS compared to AC alone (HR 1.11; 95% CI 0.82–1.51). CONCLUSIONS: Although infrequently utilized, the addition of radiotherapy to AC is not associated with improved OS in LABC. These results highlight the need for prospective trials to better define the potential benefits from PORT with regard to symptomatic progression and oncologic outcomes.
Pengaruh ukuran perusahaan, struktur aset, dan return on assets terhadap struktur modal
Authors: Astuty Risma Widya 
Published: September 2022

Tujuan dari penelitian untuk mengetahui pengaruh ukuran perusahaan, struktur aset, dan return on assets terhadap struktur modal perusahaan subsektor hotel, restoran, dan pariwisata yang rutin listing di Bursa Efek Indonesia. Jenis penelitian adalah penelitian kuantitatif. Teknik pengambilan sampel dalam penelitian ini adalah teknik purposive sampling. Sampel dalam penelitian ini adalah laporan keuangan perusahaan hotel, restoran, dan pariwisata yang rutin listing di Bursa Efek Indonesia tahun 2013-2018. Penelitian ini menggunakan data sekunder yaitu laporan keuangan tahunan. Teknik analisis menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa struktur perusahaan berpengaruh positif signifikan terhadap struktur modal, struktur aset berpengaruh negatif signifikan terhadap struktur modal, dan return on assets berpengaruh negatif tidak signifikan terhadap struktur modal.
Sinergitas Dinas Pariwisata dan Kebudayaan Kabupaten Rokan Hulu dengan The Caretaker Dalam Pengembangan Objek Wisata Suligi Hill
Authors: Irdayanti Irdayanti , Pangestuti Anggun 
Published: September 2022

Penelitian ini bertujuan untuk menjelaskan sinergitas antara Dinas Pariwisata dan Kebudayaan Kabupaten Rokan Hulu dengan The Caretaker sebuah kelompok sadar wisata dalam pengembangan objek wisata Suligi Hill hingga berhasil meraih penghargaan dalam Anugrah Pesona Indonesia (API) tahun 2019, selain itu penelitian ini bertujuan menganalisis hambatan dalam proses pengembangannya. Metode penelitian ini menggunakan pendekatan kualitatif, dengan teknik pengumpulan data yaitu wawancara, observasi, dan dokumentasi. Untuk menggambarkan sinergitas para aktor dilakukan dengan dua konsep, yaitu komunikasi dan koordinasi dan ditemukan 3 kendala dalam proses pengembangannya yaitu sarana dan prasarana, anggaran serta sumberdaya manusia yang mengelolanya. Selain itu ditemukan juga dalam pengembangan Objek Wisata Suligi Hill belum terdapat kerjasama dengan pihak swasta, sehingga pengembangan Objek Wisata Suligi Hill masih belum maksimal.
IMPLEMENTASI PROGRAM PROGRAM PEMBERDAYAAN MASYARAKAT DALAM PENINGKATAN INFRASTRUKTUR LINGKUNGAN PEMUKIMAN WILAYAH KELURAHAN (PM-PIK) DI DAERAH HINTERLAND KOTA BATAM
Authors: Aristi Novia Dwi , Nurhayati Nurhayati , Solihin Muhammad 
Published: September 2022

Pembangunan infrastruktur merupakan bagian dari pembangunan nasional. Pembangunan nasional merupakan usaha yang dilakukan sebagai langkah untuk membangun manusia Indonesia. Masalah infrastruktur yang dihadapi adalah masih kurangnya infrastruktur dasar yang ada di Kota Batam dan masih belum selesainya pusat pemerintahan Kota Batam. Permasalahan infrastruktur ini perlu di tanggulangi untuk mengatasi kesenjangan pembangunan antara wilayah Kabupaten/Kota dalam hal ketersediaan infrastruktur. Sedangkan permasalah yang ada dilapangan penyediaan infrastruktur yang dihadapi adalah belum selesainya pemerataan Pembangunan Infrastruktur fisik seperti Pembangunan jalan, pembangunan pelantar beton dan batu miring di pantai serta pembukaan akses terhadap daerah terluar atau pulau-pulau yang ada di Kecamatan Bulang. Peneliti merumuskan yaitu Bagaimana Implementasi Pembangunan Infrastruktur di Daerah Hiterland Kota Batam (Studi Penelitian Kecamatan Bulang) Tahun 2017-2018
PENGARUH PELATIHAN, PENGEMBANGAN KARIR, DAN KOMUNIKASI TERHADAP KINERJA KARYAWAN PT. TELEKOMINDO PRIMAKARYA
Authors: Ratnasari Sri Langgeng , Aidah Siti 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan, pengembangan karir, dan komunikasi terhadap kinerja karyawan PT. Telekomindo Primakarya. Pengumpulan data dilakukan melalui penyebaran kuesioner dan dilaksanakan pada 50 karyawan PT. Telekomindo Primakarya. Jenis penelitian ini adalah penelitian deskriptif kuantitatif. Populasi penelitian ini 50 orang dengan sampel 50 orang karyawan, yang dipilih secara keseluruhan sehingga memakai sampling jenuh. Hasil penelitian ini pengujian hipotesis menunjukan variabel Pelatihan nilai t hitung 1,431 t tabel 1,678 dan nilai signifikan 0,164 0,05 yang berarti Ha ditolak dan Ho diterima. Berdasarkan keriteria diatas variabel pelatihan tidak memiliki peran penting dalam mempengaruhi kinerja karyawan. -1,005 t tabel 1,678 dan nilai signifikan 0,324 0,05 yang berarti Ha ditolak Ho diterima. Berdasarkan keriteria diatas variabel pengembangan karir tidak memiliki peran penting dalam mempengaruhi kinerja karyawan. 6,355 t tabel 1,678 dan nilai signifikan 0,000 0,05 yang berarti Ha diterima Ho ditolak. Berdasarkan keriteria diatas variabel komunikasi memiliki peran penting dalam mempengaruhi kinerja karyawan. dan hasil uji F (simultan) dari hasil uji f menunjukan f hitung Hasil uji F memperlihatkan nilai F sebesar 14,564 (F hitung) 2,81 (F tabel) yang berarti Ha diterima dan Ho ditolak. Hal ini berarti bahwa secara bersama-sama variabel pelatihan, pengembangan karir, komunikasi berpengaruh terhadap kinerja karyawanjadi Ha ditolak dan Ho diterima artinya variabel Pelatihan, Pengembangan Karir, Komunikasitidak berpengaruh terhadap variabel kinerja karyawan.
Religious Peace Building; Dalam Masyarakat Multikultural Perspektif Sosiologi Agama
Authors: Sutarto Dendi 
Published: September 2022

Dalam masyarakat agama seringkali menampilkan pemahaman yang sempit hinggal melahirkan violence dan war. Agama yang seringkali dihadirkan dalam ruang yang sempit, yang hanya menjadi legitimasi atas berbagai peperangan dan diskriminasi (holy wars) yang merupakan bentuk “jihad” demi membela kebenaran. Pada konteks masyarakat multikultural pemahaman agama seringkali dihadirkan dalam mujud yang kehilangan substansi nilai universal dan toleransi. Seharusnya nilai-nailai agama diwujudkan dalam pola perilaku sosial humanity yang menyejukkan, toleran, dan tidak diskriminasi, sehingga penting religious peace building menjadi paradigm kolektif dalam kehidupan social-religious yang menyatukan unsur-unsur keberagaman dalam masyarakat multikultural. Penelitian ini dalam kerangka analisis sosiologis, dengan menganalisis data-data literatur sebagai data primer. Penelitian ini adalah penelitian literature dengan metode literature review perspektif sosiologis yang berusaha memahami pemahaman dan pemikran ked alam konteks sosialogis tindakan sosial,. Hasil penelitian ini mengungkap bahwa secara sosiologis pemahaman dan pemikiran atas nilai-nilai agama yang bersifat terbuka, toleransi, anti diskriminasi, universal dan menyejukkanperlu dibangun sebagai tindakan tindakan dan nilai-nilai dalam sistem sosio religious dalam memelihara keberangaman dan perdamaian.
Perlawanan Sangia Dowo (Sangia Nilemba), Raja Kerajaan Moronene Poleang Terhadap Kolonialisasi Belanda, 1906-1912
Authors: Fikriansyah Diky 
Published: September 2022

Tujuan penelitian ini adalah untuk: (1) Mendeskripsikan perlawanan Sangia Dowo (Sangia Nilemba) terhadap hegemoni dan kolonialisasi Belanda di Tanah Kerajaan Moronene. khususnya daerah Kerajaan Moronene Polea. (2) perundingan yang terjadi antara Sangia Dowo (Kerajaan Moronene Polea) dengan Kapten De Jongens (Belanda). (3) Inilah alasan untuk mengangkat Sangia Dowo sebagai pahlawan nasional Indonesia..Metode yang digunakan dalam penelitian ini yaitu metode sejarah yang terdiri dari lima tahap, yaitu: (1) Pemilihan topik, terbagi dua bagian yakni kedekatan dan kedekatan pendekatan, (2) Heuristik sumber, terdiri dari studi dokumen, studi kepustakaan, wawancara dan pengamatan, (3) Verifikasi sumber, yang dilakukan melalui kritik eksteren dan kritik interen, (4) Interpretasi sumber, yang dilakukan dengan analisis data dan sintesis, (5) Historiografi, yang dilakukan secara sistematis dan objektif.Hasil penelitian ini menunjukkan bahwa: (1) Ketidaksenangan dan penentangan Sangia Dowo terhadap hegemoni dan kolonialisasi Belanda yang mengakibatkan meletusnya peperangan di antara Kerajaan Moronene Polea melawan penjajah Belanda. (2) Karena ketidakmampuan Belanda menguasai Kerajaan Moronene Polea pimpinan Sangia Dowo, maka pihak Belanda melakukan sebuah tindakan tipu muslihat berupa perundingan dan meracuni Sangia Dowo. (3) Semua kejadian yang terjadi pada Sangia Dowo dan dengan memperhatikan sebab seorang tokoh diangkat menjadi pahlawan nasional, maka Sangia Dowo sangat layak untuk dijadikan pahlawan nasional Indonesia.
Kata Kunci: Sangia Dowo, Kapten De Jongens, Perang, Perjanjian
Penggunaan Komunikasi Nonverbal dalam Perkawinan Campuran
Authors: Biâ€™an Dina Dewita , Waluyo Lukman Saleh , Wiradharma Gunawan 
Published: September 2022

Salah satu aspek dalam kajian komunikasi antar budaya adalah komunikasi yang terjadi di antara perkawinan campuran pasangan suami istri yang berasal dari dua latar belakang budaya berbeda. Komunikasi yang berlangsung di antara mereka disebut komunikasi antarbudaya. Artikel ini akan membahas sejauh mana penggunaan komunikasi nonverbal pada proses komunikasi yang berlangsung pada pasangan beda kewarganegaraan. Metodologi yang dipakai adalah kualitatif fenomenologi dengan teknik nonprobabilita purposif sampling. Hasil penelitian ini adalah budaya dan psikologis berpengaruh dalam proses komunikasi seseorang. Fungsi komunikasi nonverbal dalam perkawinan campuran dapat berbeda karena dipengaruhi beberapa hal, salah satunya adalah penggunaan bahasa verbal. Miskomunikasi dapat terjadi ketika orang antarbudaya berkomunikasi. Komunikasi antarbudaya dapat dikatakan efektif apabila kedua pihak dapat secara akurat memprediksi dan menjelaskan perilaku masing-masing.

The practice of mixed marriage between husband and wife comes from two different cultural backgrounds, the communication that is different between them is called intercultural communication. The methodology used is qualitative phenomenology with a non-probability purposive sampling technique. This study is conducte to determine the use of nonverbal communication in the communication process that occurs in couples of different nationalities. The results obtained from this study are cultural and psychological influences on a personâ€™s communication process. The function of nonverbal communication in communication in mixed marriages can be different because it is influence by several things, one of which is the use of verbal language. Miscommunication can occur when people across cultures communicate. Intercultural communication can be said to be effective if both parties can accurately predict and explain each otherâ€™s behavior.
Design, synthesis and cytotoxic evaluation of novel betulonic acid-diazine derivatives as potential antitumor agents
Authors: Shu Yisong , Li Feifei , Han Yaotian , Wang Penglong , Gao Feng , Yan Mengmeng , Liang Miao , Ma Qiang , Zhang Yuzhong , Ding Xia , Lei Haimin 
Published: September 2022

With the purpose to improve antiproliferative activity, 26 new betulonic acid-diazine derivatives were designed and synthesized from betulinic acid. The anticancer activity of these semi-synthetic compounds was evaluated by MTT assay in both tumor cell lines and normal cell line. The results indicated that majority of new compounds exhibited improved antitumor activity compared with the parent compound betulonic acid. Compound BoA2C, in particular, had the most significant action with IC50 value of 3.39 μM against MCF-7 cells, while it showed lower cytotoxicity on MDCK cell line than cisplatin. Furthermore, we discovered that BoA2C strongly increased MCF-7 cell damage mostly by influencing arginine and fatty acid metabolism. In addition, the structure-activity relationships were briefly discussed. The results of this study suggested that the introduction of different diazines at C-28 could selectively inhibit different kinds of cancer cells and might be an effective way to synthesize potent anticancer lead compound from betulonic acid.
Peripheral artery disease, abnormal ankle-brachial index, and prognosis in patients with acute coronary syndrome
Authors: Berkovitch Anat , Iakobishvili Zaza , Fuchs Shmulik , Atar Shaul , Braver Omri , Eisen Alon , Glikson Michael , Beigel Roy , Matetzky Shlomi 
Published: September 2022

ObjectivesAnkle-brachial index (ABI) is an independent prognostic marker of cardiovascular events among patients with coronary artery disease (CAD). We aimed to investigate the outcome of patients hospitalized with acute coronary syndrome (ACS) and abnormal ABI.Approach and resultsABI was prospectively measured in 1,047 patients hospitalized due to ACS, who were stratified into three groups, namely, those with clinical peripheral artery disease (PAD) (N= 132), those without clinical PAD but with abnormal (&lt; 0.9) ABI (subclinical PAD;N= 148), and those without clinical PAD with normal ABI (no PAD;N= 767). Patients were prospectively followed for 30-day major adverse cardiovascular event (MACE) and 1-year all-cause mortality. The mean age was 64 years. There was a significant gradual increase throughout the three groups in age, i.e., the incidence of prior stroke, diabetes mellitus, and hypertension (p for trend = 0.001 for all). The in-hospital course showed a gradual rise in the incidence of complications with an increase in heart failure [2.5, 6.1, and 9.2%, (p for trend = 0.001)] and acute kidney injury [2, 4.1, and 11.5%, (p for trend = 0.001)]. At day 30, there was a stepwise increase in MACE, such that patients without PAD had the lowest rate, followed by subclinical and clinical PADs (3.5, 6.8, and 8.1%, respectively, p for trend = 0.009). Similarly, there was a significant increase in 1-year mortality from 3.4% in patients without PAD, through 6.8% in those with subclinical PAD, to 15.2% in those with clinical PAD (p for trend = 0.001).ConclusionSubclinical PAD is associated with poor outcomes in patients with ACS, suggesting that routine ABI screening could carry important prognostic significance in these patients regardless of PAD symptoms.
Relation of quantitative flow ratio with transit time coronary artery bypass graft flow measurement
Authors: Chen Cong , Zhao Yang , Li Wei , Zhang Kui , Dang Haiming , Liu Taoshuai , Song Yue , Zheng Jubing , Dong Ran 
Published: September 2022

BackgroundQuantitative flow ratio (QFR) is a new functional index to assess the functional significance of coronary stenosis. While whether there is an association between QFR and transit-time flow measurement (TTFM) parameters of the target coronary artery has not been well addressed.MethodsA total of 89 patients receiving the in situ left internal thoracic artery (LITA) grafts to the left anterior descending artery (LAD), and 19 patients undergoing the saphenous vein grafts (SVG) were enrolled in this retrospective study. The QFR value of the LAD was evaluated preoperatively. According to the QFR values, patients with the LITA to the LAD bypass grafts were divided into two groups (group A1: QFR &lt; 0.75, group A2: QFR ≥ 0.75), and SVG patients were divided into two groups (V1 group: QFR &lt; 0.75, V2 group: QFR ≥ 0.75).ResultsIn groups A1 and A2, respectively, median graft flow (Qm) was 44 (34) mL/minute and 26.5 (30.0) ml/minute; median pulsatility index (PI) was 2.00 (1.00) and 2.65 (0.90). Significant differences were observed in Qm (P = 0.034) and PI (P = 0.030). And the correlation coefficients of the TTFM variables with QFR were Qm: r = r = −0.226, (P = 0.036), PI: r = 0.265 (P = 0.012) among the LITA to LAD population.ConclusionTTFM variables, especially the PI, of the LITA in situ graft to the LAD during Coronary artery bypass grafting (CABG) are strongly affected by preoperative QFR values. Moreover, in functionally mild coronary stenosis, the chance of competitive flow increases.
The challenge of developing ecohydrological metrics for vegetation communities in calcareous fen wetland systems
Authors: Bijkerk Ella , Regan Shane , Johnston Paul M. , Coxon Catherine , Gill Laurence W. 
Published: September 2022

Calcareous fens are peat-wetlands fed mainly by groundwater, located in topographic hollows and served by springs or seepages of water derived by contact with base-rich mineral ground. In the European Union they are protected habitats requiring special conservation measures. To better understand the environmental supporting conditions of alkaline fen habitat found in Ireland, a 2-years hydrological and hydrochemical monitoring programme was carried out on four contrasting fen sites that covered an ecohydrological gradient representing intact to highly degraded conditions. This paper presents a methodology (and its limitations) of how the evaluation of the temporal and spatial variability of the quality and hydrological dynamics associated with different representative vegetation communities within the four fens can be used to develop ecohydrological metrics for fen habitat. The conditions supporting fen habitat in “good” ecological condition, indicative of a functioning alkaline habitat, were determined and contrasted with conditions found in habitats deemed to be in “poor” ecological condition. Results indicate that an annual water level always above the ground surface within a threshold depth envelope of between 0.030 and 0.28 m is required for at least 60% of the year for healthy fen vegetation. In terms of hydrochemistry, higher concentrations of nutrients were found in the sediments at depth and the groundwater feed compared to the phreatic water table. This suggests the fens may be incorporating the incoming nutrients into their internal biogeochemical cycles and that there is a net accumulation of nutrients within the wetlands. Although envelopes of nutrient concentrations in the surface water of the fen associated with habitat in good ecological condition can be defined (e.g., dissolved reactive phosphorus concentrations of between 6 and 37 µg-P/l for PF1 habitat), these levels should be regarded as the water quality after the fen vegetation has effectively interacted with the higher incoming nutrient levels in the groundwater. Moreover, the local hydrogeological conditions that define groundwater pathways (and associated water quality impacts) in such calcareous fens, allied to the localized nature of these measurements in these field studies, makes it difficult to define groundwater water quality threshold values with any confidence.