bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Single Manual Medicine Treatment for Infants with Postural
and Movement Asymmetries and Positional Preference: A Multicentre Randomised
Controlled Trial – SMMT for IPMA
Authors: Sacher Robby , Wuttke Marc , Göhmann Ulrich , Kayser Christian , Knabe-Ulner Kirsti , Ammermann Elke , Ammermann Michael , Krocker Bodo , Fünfgeld Liv , Spittank Holger , Derlien Steffen , Loudovici-Krug Dana 
Published: February 2022

Abstract
Objective The aim of the study was the evaluation of the effects of a
single manual medicine treatment (SMMT) for infants with postural and motor
asymmetries in upper cervical asymmetry disorder respectively kinematic
imbalance due to suboccipital strain (KISS).
Methods Design: Multicentre double-blind randomised study
Subjects/Setting: 202 infants at the age of 14–24 weeks with
postural and movement findings were examined in four study centres using the
standardized 4-item Symmetry-Score (points: 4=symmetric to
17=asymmetric). The inclusion criterion was a score of at least 10
points. The intervention group (IG) received a SMMT, whereas the control group
(CG) did not receive any manual therapy. In addition, the infants of both groups
were trained with a home exercise programme by their parents.
Statistical Methods The primary target parameter was the result of the
Symmetry-Score, measured before the intervention and 4–6 weeks
afterwards.
Results 171 children were randomised
(IG=83/CG=88). All infants enrolled were measured to the
second time-point (Intention-to-treat-analysis). The average improvement of IG
compared to CG in Symmetry-Score was 2.3 points (p<.001). Following the
score definition 80% of IG and 49% of CG fell below the
treatment threshold of 10 points. No side effects were observed.
Conclusions The SMMT significantly improves postural and motor asymmetries
in infants with KISS.
Akademisierung und Professionalisierung
Authors: Lange Ute 
Published: February 2022

Eine Chance – nicht nur für HebammenDas neue Hebammengesetz ist ein wichtiger Schritt zur Professionalisierung des Hebammenberufs. Deutschland ist als letzter EU-Mitgliedsstaat den Empfehlungen der WHO gefolgt, hat die Hebammenausbildung an internationale Standards angepasst und auf Hochschulniveau angehoben.
Ultraschalluntersuchungen in der Kinderrheumatologie
Authors: Roth Johannes , Windschall Daniel 
Published: February 2022

ZusammenfassungMit zunehmendem Einsatz des Gelenkultraschalls zeigt sich eine stetige Verbesserung der diagnostischen Möglichkeiten bei der Diagnosestellung, Abgrenzung und im Verlaufsmonotoring kindlich rheumatischer Erkrankungen. So können entzündliche Erkrankungen des kindlichen Kniegelenkes hervorragend differenziert und im Verlauf kontrolliert werden. Neben den typischen sonografischen Zeichen einer Gelenkentzündung lassen sich am Kniegelenk auch rheumatische Sehnenansatzentzündungen und Schleimbeutelentzündungen sicher nachweisen. Wichtige Differenzialdiagnosen können bereits sonografisch ausgeschlosssen oder bestätigt werden. Zunehmende Standards helfen bei der praktischen Durchführung, Beurteilung und Quantifizierung des pathologischen Kniegelenkbefundes.
Sarkopenie in der Rheumatologie
Authors: Bühring Björn , Müller Celina , Parvaee Roshnak , Baraliakos Xenofon , Braun Jürgen , Bauhammer Jutta 
Published: February 2022

ZUSAMMENFASSUNGSarkopenie bezeichnet laut aktueller Definitionen, z. B. der durch die European Working Group on Sarcopenia in Older People (EWGSOP) im Jahre 2019 erstellten Definition, den Verlust an Muskelmasse, -kraft und -leistung. Von einer primären, altersbedingten Sarkopenie wird eine sekundäre unterschieden, zu deren Ursachen Immobilität, inadäquate Ernährung, Medikamente wie Glukokortikoide und systemische Erkrankungen, wie z. B. chronisch entzündliche Erkrankungen zählen. Die in der Literatur berichtete Prävalenz der Sarkopenie bei entzündlich rheumatischen Erkrankungen variiert aufgrund verschiedener Definitionen und untersuchten Populationen stark, beträgt aber bei der rheumatoiden Arthritis ca. 30 %. Neben dem Alter sind erhöhte Entzündungsmediatoren, Glukokortikoid-Therapie, körperliche Inaktivität und Krankheitsdauer weitere Risikofaktoren. Eine Sarkopenie hat direkten Einfluss auf die Mobilität und Eigenständigkeit älterer Menschen. Sie ist assoziiert mit einer erhöhten Gesamtsterblichkeit, Stürzen, Krankenhausaufenthalten sowie weiteren Funktionsparametern des täglichen Lebens. Im Behandlungsalltag kann die Sarkopenie durch einfache Assessments rasch erfasst werden. Therapieoptionen bestehen aus Bewegungs- und Krafttraining sowie einer ausgewogenen, proteinreichen Ernährung.
Dual-Layer Spectral Detector CT in Comparison with FDG-PET/CT for the Assessment of Lymphoma Activity
Authors: Gehling Kim , Mokry Theresa , Do Thuy Duong , Giesel Frederik Lars , Dietrich Sascha , Haberkorn Uwe , Kauczor Hans-Ulrich , Weber Tim Frederik 
Published: February 2022

Purpose In patients with malignant lymphoma, disease activity is recommended to be assessed by FDG-PET/CT and the Deauville five-point scale (5-PS). The purpose of this study was to explore the potential of iodine concentration measured in contrast-enhanced dual-layer spectral detector CT (SDCT) as an alternative surrogate parameter for lymphoma disease activity by investigating its correlation with maximum standardized uptake values (SUVmax) and 5-PS.
Materials and Methods 25 patients were retrospectively analyzed. Contrast-enhanced SDCT and FDG-PET/CT were performed in the same treatment interval within at most 3 months. CT attenuation values (AV), absolute iodine concentrations (aIC), and normalized iodine concentrations (nIC) of lymphoma lesions were correlated with SUVmax using Spearman’s rank correlation coefficient. The performance of aIC and nIC to detect lymphoma activity (defined as 5-PS > 3) was determined using ROC curves.
Results 60 lesions were analyzed, and 31 lesions were considered active. AV, aIC, and nIC all correlated significantly with SUVmax. The strongest correlation (Spearman ρ = 0.71; p < 0.001) and highest area under the ROC curve (AUROC) for detecting lymphoma activity were observed for nIC normalized to inferior vena cava enhancement (AUROC = 0.866). The latter provided sensitivity, specificity, and diagnostic accuracy of 87 %, 75 %, and 80 %, respectively, at a threshold of 0.20. ROC analysis for AV (AUROC = 0.834) and aIC (AUROC = 0.853) yielded similar results.
Conclusion In malignant lymphomas, there is a significant correlation between metabolic activity as assessed by FDG-PET/CT and iodine concentration as assessed by SDCT. Iodine concentration shows promising diagnostic performance for detecting lymphoma activity and may represent a potential imaging biomarker.
Key Points:
Citation Format
Reliability of the Modified Four-Square Step Test in Revision Total
Knee Arthroplasty: A Cross-Sectional Study
Authors: Unver Bayram , Sevik Kevser , Karatosun Vasfi 
Published: February 2022

Abstract
Background The modified four-square step test (mFSST) assesses dynamic
balance by rapid stepping in different directions. This study aimed to evaluate
the reliability of the mFSST in patients who had undergone revision total knee
artroplasty (rTKA).
Methods The study was designed as a cross-sectional study. The mFSST was
administered on 22 patients with a history of rTKA. Two trials were performed
and the patients rested between trials to avoid fatigue.
Results The intraclass correlation coefficient (ICC) for the mFSST was
0.83. The standard error of measurement and the smallest real difference
(95%. confidence level) were 0.67 and 1.85 respectively.
Conclusion The mFSST showed good reliability in patients who had undergone
rTKA. The mFSST is a reliable measure for the assessment of gait variability,
dynamic balance, walking skills and mobility. It can easily detect changes in
rTKA patients with simple equipment.
Endoscopic vacuum therapy (EVT) for acute esophageal perforation: Could it replace surgery?
Authors: Stathopoulos Petros , Zumblick Malte , Wächter Sabine , Schiffmann Leif , Gress Thomas M. , Bartsch Detlef , Seitz Guido , Denzer Ulrike W. 
Published: February 2022

Abstract
Background and study aims Acute esophageal perforation is a potentially life-threating condition that demands a multidisciplinary approach. Based on recently published data indicating that EVT may be effective in managing esophageal perforation, we report our institution’s experience with EVT in this clinical setting.
Patients and methods We retrospectively analyzed all 10 patients with acute esophageal perforation from May 2018 to January 2021, using descriptive statistics. The primary outcome was successful closure of the perforation. Secondary outcomes included the length of treatment, number of endoscopic procedures required, and complication rate.
Results All patients (site of perforation: 4 upper, 2 middle, 4 lower esophagus; etiology: 8 iatrogenic, 2 foreign body ingestion) were treated with EVT successfully. In eight cases, EVT was started immediately after the perforation, in the other two cases 1 and 2 days later. The median (interquartile range) number of endoscopic procedures was 2.5 (range, 2–3) and the median duration of treatment was 7.5 days (range, 7–11.5). The sponge was placed in eight cases intraluminally, in the other two cases initially intracavitary. No complication occurred.
Conclusions EVT is highly effective for managing acute esophageal perforation within 1 to 3 weeks. Immediate start of EVT to prevent abscess formation and induce defect closure is crucial.
Protective Effects of Platelet-rich plasma for in vitro Fertilization of Rats with Ovarian Failure Induced by Cyclophosphamide
Authors: Budak Özcan , Bostancı Mehmet Sühha , Toprak Veysel , Doğanay Songül , Köse Osman 
Published: February 2022

Abstract
Objective Premature ovarian insufficiency (POI) contributes significantly to female infertility. Cyclophosphamide (CYC has adverse effects on folliculogenesis. Platelet-rich plasma (PRP) is an autologous product rich in many growth factors. We evaluated the protective effect of PRP on in vitro fertilization in female rats with CYC-induced ovarian damage.
Methods Twenty-eight adult female Sprague-Dawley rats were randomly divided into four groups. Group 1 (control-sodium chloride 0.9%; 1 mL/kg, single-dose intraperitoneal [IP] injection); group 2 (CYC), 75 mg/kg, single-dose IP injection and sodium chloride 0.9% (1 mL/kg, single-dose IP injection); group 3 CYC plus PRP, CYC (75 mg/kg, single-dose and PRP (200 μl, single-dose) IP injection); and group 4 (PRP, 200 μl, single-dose IP injection).
Results In the comparisons in terms of M1 and M2 oocytes, it was observed that the CYC group presented a significantly lower amount than the control, CYC/PRP, and PRP groups. (for M1, p = 0.000, p = 0.029, p = 0.025; for M2, p = 0.009, p = 0.004, p = 0.000, respectively). The number of fertilized oocytes and two-celled good quality embryos was found to be statistically significant between the CYC and control groups, CYC + PRP and PRP groups (p = 0.009, p = 0.001, p = 0.000 for oocytes, respectively. For embryos; p = 0.016, p = 0.002, p = 0.000).
Conclusion Platelet-rich plasma can protect the ovarian function against damage caused by CYC, and, in addition, it improves oocyte count and the development of embryos as a result of oocyte stimulation during the IVF procedure.
Analysis of the Correlation/Agreement of Maternal–fetal Doppler Parameters in Normal and Growth-Restricted Fetuses
Authors: Pinsuti Ederlei Munhoz , Bruns Rafael Frederico , Kulak Júnior Jaime , Carvalho Newton Sérgio , Nascimento Dênis José , Zamarian Ana Cristina Perez , Araújo Júnior Edward 
Published: February 2022

Abstract
Objective To assess the degree of correlation/agreement of maternal–fetal Doppler parameters between normal and growth-restricted fetuses (fetal growth restriction [FGR]).
Methods The present observational and retrospective study included 274 singleton pregnancies. The following maternal–fetal Doppler parameters were assessed: uterine artery (UAt), umbilical artery (UA), middle cerebral artery (MCA), cerebroplacental ratio (CPR), and umbilical–cerebral ratio (U/C). The assessment of FGR was based on the Figueiras and Gratacós9 criteria. Spearman correlation coefficients were estimated to assess the correlation between resistance (RI) and pulsatility (PI) indices of Doppler parameters. The agreement between two Doppler parameters was assessed by the Kappa coefficient.
Results In total, 502 Doppler examinations were included, and FGR was observed in 19 out of 274 fetuses. A strong correlation was observed between RI and PI of UAt, UA, and MCA in all of the samples (p < 0.001). Of the 502 Doppler examinations, there was agreement between U/C and CPR percentiles for 480 (95.6%) and disagreement for 22 (4.4%), with Kappa coefficient of 0.26, thereby corresponding to weak agreement. Of the 68 cases with estimated fetal weight ≤ 9th percentile (small for gestational age [SGA]), there was agreement between U/C > 1.0 and CPR < 5th percentile in 61 (88.4%) and disagreement in 7 (5.8%) with Kappa coefficient of 0.49, thereby corresponding to moderate agreement.
Conclusion Strong correlation was observed among RI and PI UAt, UA, and MCA Doppler examinations in the present study; however, weak agreement was observed between U/C and CPR in the normal and FGR fetuses. In SGA, U/C and CPR demonstrated moderate agreement.
Implications of autonomous shipping for maritime education and training: the cadet’s perspective
Authors: Bogusławski Krzysztof , Gil Mateusz , Nasur Jan , Wróbel Krzysztof 
Published: February 2022

AbstractThe Industrial Revolution 4.0 has not left the transportation sector behind. All modes of transportation have, to some extent, already been affected, and maritime is the last to join them. Currently available technology makes autonomous merchant ships a possible alternative to conventional, manned vessels with seafarers. This upcoming shift requires the preparation of necessary policies, such as rethinking obsolete training curricula, in relation to a variety of aspects of the industry, including the future of seafaring as a profession. To formulate such policies, the views of professional seafarers and scholars are sometimes solicited, but the opinions of industry entrants are often neglected. However, the latter may also have some interesting views on the future of their profession, which may be relevant to policy-makers. The results of a worldwide survey, conducted using the Computer-Assisted Web Interviewing (CAWI) method, suggest that the future generation of seafarers fears automation less than their mentors. Although they expect their skills to be useful in automation-driven shipping, they also feel that their Maritime Education and Training institutions (MET) are not doing enough to prepare them for the challenges that the future may hold. This may be due to a lack or poor coverage of shipping autonomization issues in MET curricula, which was mentioned by as many as 41.9% of the respondents. This finding advocates for rethinking the curricula of METs and human resources management in the shipping industry of the future.
Indirect influence in social networks as an induced percolation phenomenon
Authors: Xie Jiarong , Wang Xiangrong , Feng Ling , Zhao Jin-Hua , Liu Wenyuan , Moreno Yamir , Hu Yanqing 
Published: February 2022

Significance
Increasing empirical evidence in diverse social and ecological systems has shown that indirect interactions play a pivotal role in shaping systems’ dynamical behavior. Our empirical study on collaboration networks of scientists further reveals that an indirect effect can dominate over direct influence in behavioral spreading. However, almost all models in existence focus on direct interactions, and the general impact of indirect interactions has not been studied. We propose a new percolation process, termed induced percolation, to characterize indirect interactions and find that indirect interactions raise a plethora of new phenomena, including the wide range of possible phase transitions. Such an indirect mechanism leads to very different spreading outcomes from that of direct influences.
Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
Authors: Kwon Taejoon , Ra Jae Sun , Lee Soyoung , Baek In-Joon , Khim Keon Woo , Lee Eun A , Song Eun Kyung , Otarbayev Daniyar , Jung Woojae , Park Yong Hwan , Wie Minwoo , Bae Juyoung , Cheng Himchan , Park Jun Hong , Kim Namwoo , Seo Yuri , Yun Seongmin , Kim Ha Eun , Moon Hyo Eun , Paek Sun Ha , Park Tae Joo , Park Young Un , Rhee Hwanseok , Choi Jang Hyun , Cho Seung Woo , Myung Kyungjae 
Published: February 2022

Significance
The targeted killing of cancer cells without affecting surrounding normal cells is the most desirable approach for cancer therapy; however, it cannot be easily achieved, owing to the shared properties of normal and cancer cells. Using CRISPR-Cas9 targeting multiple cancer-specific mutations, we developed an innovative approach called cancer-specific insertions and deletions attacker that can induce targeted cancer cell death by simultaneous and multiple DNA double-strand breaks. As demonstrated in cell lines, cancer patient–driven cells and xenografts, the concept proposed in this study may become a potential approach for personalized cancer treatments.
Modeling suggests gene editing combined with vaccination could eliminate a persistent disease in livestock
Authors: Petersen Gertje Eta Leony , Buntjer Jaap B. , Hely Fiona S. , Byrne Timothy John , Doeschl-Wilson Andrea 
Published: February 2022

SignificanceThis proof-of-concept modeling study offers quantitative insights into the potential epidemiological benefits of gene-editing technologies and how these may be most effectively implemented to control one of the most harmful pig diseases to date. In the future, the epidemiological benefits will need to be complemented by systematic assessment of economic and technological feasibility to enable balancing these against ethical and societal concerns.
Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
Authors: Singh Ranjan K. , Soliman Ahmed , Guaitoli Giambattista , Störmer Eliza , von Zweydorf Felix , Dal Maso Thomas , Oun Asmaa , Van Rillaer Laura , Schmidt Sven H. , Chatterjee Deep , David Joshua A. , Pardon Els , Schwartz Thomas U. , Knapp Stefan , Kennedy Eileen J. , Steyaert Jan , Herberg Friedrich W. , Kortholt Arjan , Gloeckner Christian Johannes , Versées Wim 
Published: February 2022

SignificanceParkinson’s disease (PD) is the second-most common neurodegenerative disorder. Mutations leading to overactivation of LRRK2 are a leading cause of familial PD, and this protein is therefore considered as an appealing target for drug design. Here, we describe the discovery and characterization of a diverse set of LRRK2-targeting nanobodies. A subset of these nanobodies inhibit LRRK2 via a mechanism that differs from the commonly used LRRK2 kinase inhibitors. Importantly, some of these nanobodies selectively inhibit certain LRRK2 activities (Rab phosphorylation) while leaving other activities (autophosphorylation) unaffected. We anticipate that these nanobodies will find multiple applications as research tools and will open up opportunities for the development of new PD diagnostics and therapeutics in parallel to other currently pursued strategies.
Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases
Authors: Bhusal Ram Prasad , Aryal Pramod , Devkota Shankar Raj , Pokhrel Rina , Gunzburg Menachem J. , Foster Simon R. , Lim Herman D. , Payne Richard J. , Wilce Matthew C. J. , Stone Martin J. 
Published: February 2022

Significance
Inflammatory diseases collectively account for numerous deaths and morbidity worldwide. New treatment approaches are needed. A central feature of inflammatory diseases is the recruitment of leukocytes to the affected tissues, which is stimulated by secreted proteins called chemokines. Effective suppression of leukocyte recruitment could be achieved by simultaneously targeting multiple chemokines, a natural molecular strategy used by tick salivary proteins called evasins. Here, we describe the structural and molecular features of a tick evasin that control its ability to bind and block a limited set of chemokines. By modifying these features, we demonstrate that evasins can be engineered to alter the array of chemokines that they target. Thus, this study establishes a structure-based paradigm for the development of antiinflammatory therapeutics.
CSB-independent, XPC-dependent transcription-coupled repair in
Drosophila
Authors: Deger Nazli , Cao Xuemei , Selby Christopher P. , Gulec Saygin , Kawara Hiroaki , Dewey Evan B. , Wang Li , Yang Yanyan , Archibald Sierra , Selcuk Berkay , Adebali Ogun , Sekelsky Jeff , Sancar Aziz , Liu Zhenxing 
Published: February 2022

Significance

We have discovered that
Drosophila
, which does not have the canonical TCR homologs, does nevertheless carry out TCR as efficiently as organisms that do. Furthermore, using the XR-seq and in vivo excision assay we have also shown that both global repair and TCR in
Drosophila
are dependent on the XPC protein and in that regard,
Drosophila
excision repair is more similar to the monocellular eukaryotic yeast repair system than it is to multicellular eukaryotes. Finally, we have generated genome-wide single nucleotide repair maps of
Drosophila
for CPDs, (6-4) photoproducts, and cisplatin-d(GpG) adducts that should be a useful source for investigators working on DNA damage, repair, and mutagenesis in
Drosophila
.
¿A poco así dices?Biased interrogatives with¿A poco (no)…?in Mexican Spanish
Authors: Alamillo Asela Reig 
Published: February 2022

AbstractThis article offers a characterization of the biased polar interrogative with¿a poco (no)?, frequent in Mexican Spanish. This characterization is based on the system proposed bySudo (2013)and shows that Sudo’s two notions of epistemic bias and evidential bias are necessary and sufficient to characterize the conventional non-propositional meaning associated with the three kinds ofa pocoquestions in Mexican Spanish: thea pocopositive polarity question codes a negative epistemic bias and a [+positive] or [+negative] evidential bias; thea poconegative polarity question with inside negation codes a positive epistemic bias and a [+negative] evidential bias; and thea poconegative polarity question with outside negation codes a positive epistemic bias and a [−negative] evidential bias. Lastly, the article discusses to what extent these characterizations are also compatible with the interactional uses of the short questions¿a poco?and¿a poco no?