bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diseases prevalent before major depressive disorder diagnosis: an exploratory nested case–control study using health insurance-based claims data
Authors: Cho Yoshinori , Mishiro Izumi , Akaki Tsuyoshi , Akimoto Takafumi , Fujikawa Keita 
Published: February 2022

ObjectivesMajor depressive disorder (MDD) is often comorbid with other chronic and/or serious diseases. However, little is known about the prevalence of various diseases that are present before MDD onset. We examined the prevalence of all pre-existing diseases in the 12 months before an MDD diagnosis.DesignExploratory nested case–control study.SettingData, including diagnoses based on International Statistical Classification of Diseases and Related Health Problems, 10th revision codes, were from a Japanese health insurance database (JMDC).ParticipantsAdults newly diagnosed with MDD during 2015, 2016 or 2017 (but not the preceding year) (cases) were matched (exact) 1:10 to controls by age, sex, index date and working status.Primary and secondary outcome measuresThe primary outcome was the proportion of patients in each group with each pre-existing disease during the 12 months before the index date (ie, before MDD diagnosis in cases). Odds ratios (ORs) for onset of MDD were calculated for each pre-existing disease. A post hoc multivariate analysis examined interactions of metabolic risk factors (diabetes, hypertension, dyslipidaemia), psychiatric disorders (sleep disorders, psychiatric disorders other than depression) and MDD-related symptoms (headache, pain, autonomic nerve imbalance) on MDD diagnosis.ResultsThere were 13 420 cases and 134 200 controls (mean age 41.9 years; 66.5% male). The prevalence of almost all pre-existing diseases was higher in cases than in controls. The highest ORs (5.8–21.0) were for psychiatric diseases and sleep disorders. Insomnia (21.1% of patients; OR 8.7) and neurosis (9.7%; OR 10.6) were particularly prevalent in the case group. The odds of MDD increased in the presence of metabolic risk factors, psychiatric disorders and/or MDD-related symptoms.ConclusionsThere is a high prevalence of pre-existing diseases in Japanese patients who develop MDD compared with matched controls without MDD. These results suggest that patients with chronic and/or serious diseases should be actively monitored for depression.
Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study
Authors: Heijdra Jessica M , Al Arashi Wala , de Jager Nico C B , Cloesmeijer Michael E , Bukkems Laura H , Zwaan Christian M , Leebeek Frank W G , Mathôt Ron A A , Cnossen Marjon H 
Published: February 2022

IntroductionVon Willebrand disease (VWD) is a bleeding disorder, caused by a deficiency or defect of von Willebrand factor (VWF). In case of medical procedures or bleeding, patients are treated with desmopressin and/or VWF-containing concentrates to increase plasma VWF and factor VIII (FVIII). However, in many cases these factor levels are outside the targeted range. Therefore, population pharmacokinetic (PK) models have been developed, which aim to quantify and explain intraindividual and interindividual differences in treatment response. These models enable calculation of individual PK parameters by Bayesian analysis, based on an individual desmopressin test or PK profile with a VWF-containing concentrate. Subsequently, the dose necessary for an individual to achieve coagulation factor target levels can be calculated.Methods and analysisPrimary aim of this study is to assess the predictive performance (the difference between predicted and measured von VWF activity and FVIII levels) of Bayesian forecasting using the developed population PK models in four different situations: (A) desmopressin testing (n≥30); (B) medical procedures (n=70; 30 receiving desmopressin, 30 receiving VWF-containing concentrate and 10 receiving a combination of both); (C) bleeding episodes (n=20; 10 receiving desmopressin and 10 receiving VWF-containing concentrate) and (D) prophylaxis with a VWF-containing concentrate (n=3 to 5). Individuals with all types of VWD and individuals with low VWF (VWF 0.30–0.60 IU/mL) will be included. Reliability and feasibility of PK-guided dosing will be tested by assessing predictive performance, treatment duration, haemostasis, patient satisfaction and physician satisfaction.Ethics and disseminationThe OPTI-CLOT:to WiN study was approved by the medical ethics committee of the Erasmus MC, University Medical Centre Rotterdam, the Netherlands. Results of the study will be communicated through publication in international scientific journals and presentation at (inter)national conferences.Trial registration numberNL7212 (NTR7411); Pre-results, EudraCT 2018-001631-46.
Effect of a tailored multidimensional intervention on the care burden among family caregivers of stroke survivors: a randomised controlled trial
Authors: Elsheikh Mahmoud Ahmed , Moriyama Michiko , Rahman Md Moshiur , Kako Mayumi , EL-Monshed Ahmed Hashem , Zoromba Mohamed , Zehry Hamada , Khalil Maha Hazem , El-Gilany Abdel-Hady , Amr Mostafa 
Published: February 2022

ObjectivesTo evaluate the effectiveness of a tailored multidimensional intervention in reducing the care burden of family caregivers of stroke survivors. This intervention considered caregivers’ perceived needs and incorporated three evidence-based dimensions (psychoeducation, skill-building and peer support).DesignA prospective randomised control trial.SettingA community-based study conducted in Egypt.ParticipantsA total of 110 caregivers aged ≥18 years who cared for a survivor within 6 months of stroke, with modified Rankin Scale scores of 3–5, and without other physical disabilities or terminal illnesses were recruited between December 2019 and May 2020. Participants were assigned to the intervention group (IG; n=55) and control group (CG; n=55) through open-label, parallel 1:1 randomisation.InterventionThe IG was provided with tailored multidimensional interventions for 6 months until November 2020, including three home visits, six home-based telephone calls and one peer-support session. The CG received simple educational instructions at a single visit.OutcomeThe participants completed the Zarit Burden Interview (primary outcome) and the WHO Quality of Life-BREF (secondary outcome) before the intervention (T0), at 3 months (T1) and at 6 months (T2).ResultsNo differences were observed between the characteristics of the groups at baseline (T0). The independent t-test showed no significant differences in the care burden and Quality of Life (QoL) at T1 and T2 between the groups. The intervention had no significant effect on the outcomes between or within groups over time, as shown by the repeated-measures analysis of variance. However, the group and time interaction had significant main effects on caregivers’ QoL (psychological and social domains).ConclusionThe main results showed that participants in the IG did not experience an improvement in the main outcomes. Nevertheless, the improvement in the psychological and social domains may have been attributed to our intervention.Trial registration numberNCT04211662.
Urban–rural lifespan disparities and cause-deleted analysis: evidence from China
Authors: Chen Mengxue , Canudas-Romo Vladimir 
Published: February 2022

ObjectivesTo examine the length and dispersion level of lifespan for the subnational populations in China, identify the urban–rural gap and sex differences, and analyse the contribution made by causes of death.SettingCause-specific mortality data extracted from the Chinese Disease Surveillance Points system, grouped by sex and urban/rural residence.Primary outcome measuresLife expectancy and lifespan disparity are used to measure the length and dispersion level of lifespan, respectively. Cause-specific contributions are obtained by contrasting cause-deleted life expectancy and lifespan disparities with observed values.ParticipantsAggregated national data gathered from over 605 surveillance points across China, covering over 264 million people by 2016 (about 19.14% of the total Chinese population).ResultsIn the decade under observation, all subpopulations in China, by area and sex, experienced increases in life expectancy and decreases in lifespan disparity, while causes of deaths contributed differently. For example, based on the 2016 data, if cardiovascular diseases were deleted, there would be an increase in life expectancy that ranges from 5.59 years for urban males to 6.69 years for rural females. However, also lifespan disparity would increase, ranging from 0.81 years for urban females to 1.37 years for rural males.ConclusionsIn China, the urban–rural gaps in both life expectancy and lifespan disparity are shrinking as the rural residents are catching up fast, while the gender gaps remain large, and even widening. Causes of death with different age distribution patterns contribute differently to the level and direction of the urban–rural and sex differentials in life expectancy and lifespan disparity. Sex differentials were observed in cardiovascular diseases, respiratory diseases, lung and liver cancers, and external causes, while urban–rural differences were found in lung and breast cancers, and external causes.
Residency training in family medicine and its impact on coordination and continuity of care: an analysis of referrals to secondary care in Rio de Janeiro
Authors: Jantsch Adelson Guaraci , Burström Bo , Nilsson Gunnar H , Ponce de Leon Antônio 
Published: February 2022

ObjectiveTo measure the effect that residency training in family medicine (RTFM) has on continuity and coordination of care.DesignObservational cohort study using electronic health records.SettingRio de Janeiro, Brazil, public primary care system.Participants504 940 patients, 633 generalists (physicians without RTFM) and 204 family physicians (FP—doctors with 2 years of RTFM) from one health district between January 2015 and December 2018.InterventionTwo years of RTFM.Main outcome measuresRelative risks of patients being referred to secondary care for outpatient consultations and diagnostics tests; and having a follow-up medical consultation in primary care within 3 and 6 months after being referred.ResultsWe examined 2 414 508 medical consultations and 284 754 referrals to secondary care. FPs were less likely to request ambulatory care services (including surgical specialties), but were more likely to request ophthalmology, physiotherapy, rehabilitationand surgical evaluations for their patients. Patients referred to secondary care by FPs were more likely to have a follow-up visit in primary care for almost every service requested. If all medical consultations were performed by FPs, a 37.6% (95% CI 32.4% to 42.4%) increased demand for rehabilitation services would be noticed. Oppositely, 1532 (95% CI 1458 to 1602) fewer requests for dermatology would happen every year.ConclusionsRTFM improves coordination and continuity of care by making FPs more competent to retain those health conditions that can be properly managed in primary care and making FPs more competent to detect health conditions that require specific biomedical technologies and skills, increasing the demand for those services. Besides, it increases the chances of patients having follow-up visits in primary care. Policy-makers in low-income and middle-income countries must consider investing in RTFM to make primary care systems more comprehensive, with better coordination and continuity of care.
Effectiveness of a multifaceted intervention to improve interpersonal skills of physicians in medical consultations (EPECREM): protocol for a randomised controlled trial
Authors: Bellier Alexandre , Labarère José , Putkaradze Zaza , Cavalie Guillaume , Carras Sylvain , Pelen Félix , Paris Adeline , Chaffanjon Philippe 
Published: February 2022

IntroductionInterpersonal skills, encompassing communication and empathy, are key components of effective medical consultations. Although many organisations have implemented structured training programmes, limited evidence exists on their effectiveness in improving physician interpersonal skills. This study aims to evaluate the effectiveness of a standardised, multifaceted, interpersonal skills development programme for hospital physicians.Methods and analysisThis study is a prospective, randomised (with a 1:1 allocation ratio), controlled, open-label, two parallel arm, superiority trial conducted at a single university hospital. Physicians will be randomised to receive either a multifaceted training programme or no intervention. The experimental intervention combines two 4-hour training sessions, dissemination of interactive educational materials, review of video-recorded consultations and individual feedback. The primary outcome measure is the overall 4-Habits Coding Scheme score assessed by two independent raters blinded to the study arm, based on video-recorded consultations, before and after intervention. The secondary outcomes include patient satisfaction, therapeutic alliance, physician self-actualisation and the length of medical consultation.Ethics and disseminationThe study protocol was approved on 21 October 2020 by the CECIC Rhône-Alpes Auvergne, Clermont-Ferrand, France (IRB 5891). All participants will provide written informed consent. Efforts will be made to release the primary results within 6 to 9 months of study completion, regardless of whether they confirm or deny the research hypothesis.Trial registration numberNCT04703816.
Impact of night and shift work on metabolic syndrome and its components: a cross-sectional study in an active middle-to-older-aged population-based sample
Authors: Bayon Virginie , Berger Mathieu , Solelhac Geoffroy , Haba-Rubio José , Marques-Vidal Pedro , Strippoli Marie-Pierre , Preisig Martin , Leger Damien , Heinzer Raphael 
Published: February 2022

ObjectivesTo examine the effects of work schedules on metabolic syndrome and its components in active middle-to-older-aged workers.MethodsA cross-sectional analysis including middle-to-older-aged active workers from the population-based CoLaus|PsyCoLaus study (Lausanne, Switzerland) was performed. Work schedule was self-reported and defined as follows: permanent day, day shift, night shift and permanent night work. Associations between work schedule and the risk of metabolic syndrome and its components were analysed using multivariable-adjusted logistic regressions.ResultsA total of 2301 active workers (median age (IQR): 55.4 (50.8 to 60.4), 50.1% women) were included. Of these, 1905 were permanent day workers, 220 were day-shift workers, 134 were night-shift workers and 42 were permanent night-shift workers. There were significant interactions between sex and work schedule for metabolic syndrome, high triglycerides and visceral obesity. Men but not women permanent night workers had a higher prevalence of metabolic syndrome than permanent day workers in multivariable-adjusted analyses (OR 4.45 (95% CI 1.36 to 14.56)). Analysis of metabolic syndrome subcomponents showed that the association between work schedule and metabolic syndrome in men was mainly driven by visceral obesity (OR 3.35 (95% CI 1.04 to 10.76)). Conversely, women but not men working in night shift were at increased risk of having high triglycerides compared with permanent day workers (OR 2.92 (95% CI 1.03 to 8.27)).ConclusionsThe risk of metabolic syndrome is higher in men working in permanent night shift compared with permanent day work, and this association could be mediated by visceral obesity.
Scoping review of maternal and newborn health interventions and programmes in Nigeria
Authors: Nasir Naima , Aderoba Adeniyi Kolade , Ariana Proochista 
Published: February 2022

ObjectiveTo systematically scope and map research regarding interventions, programmes or strategies to improve maternal and newborn health (MNH) in Nigeria.DesignScoping review.Data sources and eligibility criteriaSystematic searches were conducted from 1 June to 22 July 2020 in PubMed, Embase, Scopus, together with a search of the grey literature. Publications presenting interventions and programmes to improve maternal or newborn health or both in Nigeria were included.Data extraction and analysisThe data extracted included source and year of publication, geographical setting, study design, target population(s), type of intervention/programme, reported outcomes and any reported facilitators or barriers. Data analysis involved descriptive numerical summaries and qualitative content analysis. We summarised the evidence using a framework combining WHO recommendations for MNH, the continuum of care and the social determinants of health frameworks to identify gaps where further research and action may be needed.ResultsA total of 80 publications were included in this review. Most interventions (71%) were aligned with WHO recommendations, and half (n=40) targeted the pregnancy and childbirth stages of the continuum of care. Most of the programmes (n=74) examined the intermediate social determinants of maternal health related to health system factors within health facilities, with only a few interventions aimed at structural social determinants. An integrated approach to implementation and funding constraints were among factors reported as facilitators and barriers, respectively.ConclusionUsing an integrated framework, we found most MNH interventions in Nigeria were aligned with the WHO recommendations and focused on the intermediate social determinants of health within health facilities. We determined a paucity of research on interventions targeting the structural social determinants and community-based approaches, and limited attention to pre-pregnancy interventions. To accelerate progress towards the sustainable development goal MNH targets, greater focus on implementing interventions and measuring context-specific challenges beyond the health facility is required.
Status of hospital-based blood transfusion services in low-income and middle-income countries: a cross-sectional international survey
Authors: Barnes Linda S , Stanley Jean , Bloch Evan M , Pagano Monica B , Ipe Tina S , Eichbaum Quentin , Wendel Silvano , Indrikovs Alexander , Cai Wei , Delaney Meghan 
Published: February 2022

ObjectivesBlood transfusion is life-saving for patients experiencing acute blood loss and severe anaemia. In low-income and middle-income countries (LMICs), low blood donation rates and unavailability of whole blood and blood components (blood products) impairs timely blood transfusion. To fulfil patient-specific blood orders, a hospital blood transfusion service (HBTS) receives orders from a prescriber for blood transfusion, tests and prepares blood products for the patient. This study sought to describe the current state of LMIC HBTS.DesignA cross-sectional survey explored LMIC HBTS access to blood products, testing methods, policies and structure. Surveys were administered in English, Spanish, French and Russian, followed by a mixed-methods analysis.SettingHBTS within LMICs.ParticipantsFrom among 124 public and private facilities invited to participate, we received 71 (57%) responses. Of these responses, 50 HBTS from 27 LMICs performed on-site blood transfusions.ResultsMost LMIC HBTS perform blood collection to generate blood products for their patients (36/47, 77%); few relied exclusively on an external supply of blood products (11/47, 23%). The primary reason for blood transfusion was adult anaemia for non-malignant conditions (17/112, 15%). Testing methods varied by gross national income per capita. Blood transfusion delays to patients were common (17/30, 57%) attributed to inadequate blood inventories (13/29, 45%). Other barriers included lack of regular clinician education about transfusion (8/29, 28%) and sustainable financial models for the HBTS (4/29, 14%).ConclusionThis survey describes the status of HBTS in diverse LMICs, illustrating that the availability of blood products remains a principal problem, requiring HBTS to generate its own facility’s blood supply. Currently, blood shortages are not reported as a patient-specific adverse event making systematic tracking of delays in transfusion difficult. These findings highlight areas for further exploration related to the lack of available blood inventories for transfusions at HBTS in LMICs.
Worsening trends in self-rated health and correlates in Chinese adolescents in Hong Kong: a population-based panel study from 1999/2000 to 2014/15
Authors: Gong Wei Jie , Fong Daniel Yee Tak , Wang Man Ping , Lam Tai Hing , Chung Thomas Wai Hung , Ho Sai Yin 
Published: February 2022

ObjectivesTo examine the 15-year secular trends of self-rated health (SRH) and correlates in Chinese adolescents in Hong Kong.DesignA territory-wide population-based panel data study.SettingAnonymised records of the annual health examination from the Student Health Service, Department of Health in Hong Kong.Participants397 324 students in Secondary 2 (US grade 8), 335 902 in Secondary 4 and 113 892 in Secondary 6 during the academic year 1999/2000 and 2014/15.Outcome measuresSRH and lifestyles were self-reported using standardised questionnaires. Sex-standardised and age-standardised prevalence of very poor/poor SRH and its secular annual changes across sex, grade, weight status, breakfast habits, and frequency/duration of aerobic exercises were examined. Their disparities over time were examined by interactions with the academic year in generalised estimating equations.ResultsThe overall prevalence of very poor/poor SRH increased from 9.3% (95% CI: 8.9% to 9.7%) in 1999/2000 to 15.5% (15.1% to 15.8%) in 2014/15. Very poor/poor SRH was more prevalent in girls (adjusted OR: 1.02), in those having unemployed parents (1.29), being overweight (1.42) or obese (2.62), eating breakfast away from home (1.27) and skipping breakfast (1.49) or doing <1 time/week or ≤60 min/week aerobic exercises (1.78 and 1.88, respectively) than others. The corresponding disparities increased over time (ratios of OR: 1.006–1.042).ConclusionsIncreasing prevalence of very poor/poor SRH from 1999/2000 to 2014/15 was found among Hong Kong Chinese adolescents, which was greater in girls, adolescents being overweight/obese and those having unemployed parents or unhealthy lifestyles. Strategies to reduce health inequality should consider multiple factors, especially modifiable factors including lifestyles.
Identifying forms of interventions towards cross border malaria in the Asia-Pacific region: a scoping review protocol
Authors: Cintyamena Utsamani , Murhandarwati E Elsa Herdiana , Elyazar Iqbal , Probandari Ari , Ahmad Riris Andono 
Published: February 2022

IntroductionAn ambitious epidemiology strategy has been set by the WHO, targeting malaria elimination for at least 35 countries in 2030. Challenges in preventing malaria cross borders require greater attention to achieve the elimination target. This scoping review aims to identify successful forms of interventions to control malaria transmission across national borders in the Asia-Pacific region.Methods and analysisThis scoping review will search four electronic databases (PubMed, ScienceDirect, EBSCOhost and ProQuest) limiting the time of publication to the last 10 years. Two independent reviewers will screen all titles and abstracts during the second stage. Study characteristics will be recorded; qualitative data will be extracted and evaluated, while quantitative data will be extracted and summarised. Overall, we will follow the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines.Ethics and disseminationThis scoping review has received ethical approval from the Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada. The results will be disseminated through peer-reviewed publications, conference presentations and policy briefs.